LOCUS 041_IIG_Bs27_026_SNP 3504449 bp DNA circular UNA 12-JAN-2021 DEFINITION Bacillus subtilis strain Delta6 (hybrid trycycler assembly). ACCESSION urn.local...1et-cvskbtp VERSION urn.local...1et-cvskbtp KEYWORDS . SOURCE ORGANISM . FEATURES Location/Qualifiers S_feature complement(3504339..658) /Source="Nicolas_S_feature" /locus_tag="new_299_1067_c" /HighExp="S4, LoTm, S3, C30, S5, S7, S6, T5.0H, S8, M9-stat" /AntisenseName="dnaA" /AntisenseCor="-0.57810076860528403" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S4" CDS 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2167836, 2846289, 12682299, 16120674, 1779750, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosomal replication initiator informational ATPase" /protein_id="NP_387882.1" /db_xref="EnsemblGenomes-Gn:BSU00010" /db_xref="EnsemblGenomes-Tr:CAB11777" /db_xref="GOA:P05648" /db_xref="InterPro:IPR001957" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013159" /db_xref="InterPro:IPR013317" /db_xref="InterPro:IPR018312" /db_xref="InterPro:IPR020591" /db_xref="InterPro:IPR024633" /db_xref="InterPro:IPR027417" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG10065" /db_xref="UniProtKB/Swiss-Prot:P05648" /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTIT APNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKED TSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQF LAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPP DLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDIN ADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMY LSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK*" /label="dnaA CDS" gene 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /label="dnaA gene" promotor_-10 complement(631..649) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657) /Source="Nicolas_upshifts" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(665..670) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1342..1529 /Source="Nicolas_S_feature" /locus_tag="new_1751_1938" /HighExp="G150, Heat, G180, G135, Paraq, Oxctl, dia0, LBGstat, S1, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S5" CDS 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2846289, 11395445, 12682299, 20453097, 23228104, 28878042" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846289, 11395445, 12682299, 20453097, 23228104, 28878042; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (beta subunit)" /protein_id="NP_387883.1" /db_xref="EnsemblGenomes-Gn:BSU00020" /db_xref="EnsemblGenomes-Tr:CAB11778" /db_xref="GOA:P05649" /db_xref="InterPro:IPR001001" /db_xref="InterPro:IPR022634" /db_xref="InterPro:IPR022635" /db_xref="InterPro:IPR022637" /db_xref="PDB:4TR6" /db_xref="SubtiList:BG10066" /db_xref="UniProtKB/Swiss-Prot:P05649" /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSF TGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQY LTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRP ILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDN QELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAID RASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKY MLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY*" /label="dnaN CDS" gene 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /label="dnaN gene" downshifts 2650 /Source="Nicolas_upshifts" /id="D1" /incds=0 /nref=29 /ntot=161 /MaxReadThrough="5.22584" /MaxDrop="4.17087" /score="21.887269" /energy="-14.2" /TU="U1" /idTUdmin="U1" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" promotor_-35 2731..2735 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752..2771 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2760 /Source="Nicolas_upshifts" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24637032, 24939895" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24637032, 24939895; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA binding protein involved in ribosome maturation" /protein_id="NP_387884.1" /db_xref="EnsemblGenomes-Gn:BSU00030" /db_xref="EnsemblGenomes-Tr:CAB11779" /db_xref="GOA:P05650" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014330" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10067" /db_xref="UniProtKB/Swiss-Prot:P05650" /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDE PDNRRGRKLYVGDVVEIEGFGSFQVVN*" /label="rlbA CDS" gene 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /label="rlbA gene" CDS 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 16061691, 16385024, 22342069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 16061691, 16385024, 22342069; Product type f: factor" /codon_start=1 /transl_table=11 /product="RecA filament-DNA complex stabilisation, ssDNA and dsDNA binding, ATP binding" /protein_id="NP_387885.1" /db_xref="EnsemblGenomes-Gn:BSU00040" /db_xref="EnsemblGenomes-Tr:CAB11780" /db_xref="GOA:P05651" /db_xref="InterPro:IPR001238" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR018078" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10068" /db_xref="UniProtKB/Swiss-Prot:P05651" /translation="MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIY VLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQ KLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQR NHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGL EELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNG RDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTI QGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK*" /label="recF CDS" gene 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /label="recF gene" misc_feature 3226..3245 /Source="Nicolas_upshift_promotors" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3244 /Source="Nicolas_upshifts" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of extracellular matrix formation" /protein_id="NP_387886.2" /db_xref="EnsemblGenomes-Gn:BSU00050" /db_xref="EnsemblGenomes-Tr:CAB11781" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG10069" /db_xref="UniProtKB/Swiss-Prot:P37525" /translation="MYIHLGDDFVVSTRDIVGIFDFKANMSPIVEEFLKKQKHKVVPS VNGTPKSIVVTVQNIYYSPLSSSTLKKRAQFMFEIDS*" /label="remB CDS" gene 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /label="remB gene" CDS 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit B)" /protein_id="NP_387887.1" /db_xref="EnsemblGenomes-Gn:BSU00060" /db_xref="EnsemblGenomes-Tr:CAB11782" /db_xref="GOA:P05652" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR011557" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR034160" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10070" /db_xref="UniProtKB/Swiss-Prot:P05652" /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWE IVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHA GGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIG ETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKN EYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNN INTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDP QFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKA RELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPL RGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAH IRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTP KPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRN FIEANARYVKNLDI*" /label="gyrB CDS" gene 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /label="gyrB gene" promotor_-10 complement(6003..6021) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(6005) /Source="Nicolas_upshifts" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(6037..6042) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 6375..6584 /Source="Nicolas_S_feature" /locus_tag="new_6784_6993" /HighExp="Cold, H2O2, G180, Oxctl, G135, G150, Sw, dia15, LBGexp, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S6" CDS 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /EC_number="5.99.1.3" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901, 27557712" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901, 27557712; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit A)" /protein_id="NP_387888.1" /db_xref="EnsemblGenomes-Gn:BSU00070" /db_xref="EnsemblGenomes-Tr:CAB11783" /db_xref="GOA:P05653" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005743" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="PDB:4DDQ" /db_xref="SubtiList:BG10071" /db_xref="UniProtKB/Swiss-Prot:P05653" /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKP VHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYM LVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVM PSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDF PTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK IADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL LALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDA VISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKL IAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVV TLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKV YRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKR TSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMG RTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKT AKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEE HVATVALVEKNEEDENEEEQEEV*" /label="gyrA CDS" gene 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /label="gyrA gene" promotor_-35 8964..8967 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 8965 /Source="Nicolas_upshifts" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 8984..9001 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 9031 /Source="Nicolas_upshifts" /id="D2" /incds=0 /nref=251 /ntot=261 /MaxReadThrough="3.73971" /MaxDrop="8.1288" /score="33.5021066" /energy="-14.1" /TU="NA" /idTUdmin="U4" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 9095..9101 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 9115..9134 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 9120..9205 /Source="Nicolas_S_feature" /locus_tag="new_9529_9614" /HighExp="LBGstat, H2O2, Paraq, Oxctl, UNK1, LBGexp, LPhT, MG-0.2, MG 25, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S7" upshifts 9120 /Source="Nicolas_upshifts" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 9191..9198 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9207 /Source="Nicolas_upshifts" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 9213..9232 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" rRNA 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-16S rRNA" gene 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /label="rrnO-16S gene" tRNA 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ile tRNA" gene 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /label="trnO-Ile gene" tRNA 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ala tRNA" gene 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /label="trnO-Ala gene" rRNA 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-23S rRNA" gene 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /label="rrnO-23S gene" rRNA 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-5S rRNA" gene 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /label="rrnO-5S gene" S_feature 14402..15459 /Source="Nicolas_S_feature" /locus_tag="new_14811_15868" /HighExp="G180, T0.0H, T0.30H, G135, T-0.40H, LBGstat, Cold, Paraq, C30, Oxctl" /AntisenseName="yaaC" /AntisenseCor="-4.5985764709218099E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S8" CDS complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387889.1" /db_xref="EnsemblGenomes-Gn:BSU00080" /db_xref="EnsemblGenomes-Tr:CAB11784" /db_xref="InterPro:IPR026988" /db_xref="SubtiList:BG10072" /db_xref="UniProtKB/Swiss-Prot:P37526" /translation="MTYHEWKDLALFYSVESTQKFLEKVYILNGINDAKKNSFKNSER FIYFLKHAESFYKQAAYSPLEIKPILLFYGMAQLIKACLITRDPHYPSHTSVLAHGVT TRKRKKQNYCFSDDEVKIQRNGLCVHFMKHLFGQSDIVDERYTMKKLLMAIPELSDIF YFQQKERFMTKVEKDKNEIFVPEEVVINYKMSDSRFAEYMSHHYQWSFTKKNEHGLLF EISPQDKEPWTSTSLLFDMEKNQYYIPSQREQFLRLPEMTIHYLILYNVGMIARYETE WWYELLTQHISDDYVLIQQFLLVSEKKFPKYASQFLLHF*" /label="yaaC CDS" gene complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /label="yaaC gene" promotor_-35 15438..15445 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 15460..15479 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 15461 /Source="Nicolas_upshifts" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(15466) /Source="Nicolas_upshifts" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(15475..15486) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(15500..15506) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /EC_number="1.1.1.205" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1722815, 17611193, 1979163, 3125411, 8917437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1722815, 17611193, 1979163, 3125411, 8917437; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inosine-monophosphate dehydrogenase" /protein_id="NP_387890.1" /db_xref="EnsemblGenomes-Gn:BSU00090" /db_xref="EnsemblGenomes-Tr:CAB11785" /db_xref="GOA:P21879" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005990" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG10073" /db_xref="UniProtKB/Swiss-Prot:P21879" /translation="MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNI PVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFL TPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE ELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIH GRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNI IAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKH GKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMG SVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKD LRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS*" /label="guaB CDS" gene 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /label="guaB gene" downshifts complement(15510) /Source="Nicolas_upshifts" /id="D3" /incds=0 /nref=33 /ntot=102 /MaxReadThrough="1.81989" /MaxDrop="4.44626" /score="-6.76739893" /energy="-12.2" /TU="NA" /idTUdmin="U12" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(15536..15636) /Source="Nicolas_upshift_promotors" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(15576) /Source="Nicolas_upshifts" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(16829..17424) /Source="Nicolas_S_feature" /locus_tag="new_17238_17833_c" /HighExp="Etha, Gly, C30, Salt, S8, S6, HiTm, S7, Sw, C90" /AntisenseName="dacA" /AntisenseCor="-0.39306815699287101" /AntisenseRegPval="-10.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S9" downshifts 16960 /Source="Nicolas_upshifts" /id="D4" /incds=0 /nref=243 /ntot=277 /MaxReadThrough="3.34899" /MaxDrop="7.78161" /score="26.7620012" /energy="-10.6" /TU="NA" /idTUdmin="U10" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 17018..17022 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 17038..17057 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 17044..17124 /Source="Nicolas_S_feature" /locus_tag="new_17453_17533" /HighExp="C30, LBGstat, G180, G150, LBGexp, G135, Lbexp, Oxctl, dia0, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S10" upshifts 17044 /Source="Nicolas_upshifts" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /EC_number="3.4.16.4" /experiment="publication(s) with functional evidences, PMID:8370539, 9864321, 10383963, 21378199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8370539, 9864321, 10383963, 21378199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)" /protein_id="NP_387891.1" /db_xref="EnsemblGenomes-Gn:BSU00100" /db_xref="EnsemblGenomes-Tr:CAB11786" /db_xref="GOA:P08750" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10074" /db_xref="UniProtKB/Swiss-Prot:P08750" /translation="MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAI MIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEIS QDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKE LGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETS SIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERN GMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGK EKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKD YGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF*" /label="dacA CDS" gene 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /label="dacA gene" promotor_-10 complement(17413..17431) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(17424) /Source="Nicolas_upshifts" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(17446..17452) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 18338 /Source="Nicolas_upshifts" /id="D5" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="6.76335" /MaxDrop="2.1925" /score="26.7620012" /energy="-10.6" /TU="U13" /idTUdmin="U10" /TUdmin=1364 /isTUend="FALSE" /label="downshifts" S_feature 18457..18565 /Source="Nicolas_S_feature" /locus_tag="new_18866_18974" /HighExp="C30, MG 15, MG 10, MG-0.1, MG 25, BMM, ferm, Cold, MG 60, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S11" promotor_-35 18535..18538 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 18553..18572 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 18567..18652 /Source="Nicolas_S_feature" /locus_tag="new_18976_19061" /HighExp="BMM, MG 25, SMM, MG 15, UNK1, MG 10, GM 150, MG-0.1, MG 150, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S12" upshifts 18567 /Source="Nicolas_upshifts" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /EC_number="4.3.3.6" /EC_number="4.-.-.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14762015, 15771487, 15911615, 16157873, 17144654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762015, 15771487, 15911615, 16157873, 17144654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, synthase subunit" /protein_id="NP_387892.1" /db_xref="EnsemblGenomes-Gn:BSU00110" /db_xref="EnsemblGenomes-Tr:CAB11787" /db_xref="GOA:P37527" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="PDB:2NV1" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10075" /db_xref="UniProtKB/Swiss-Prot:P37527" /translation="MAQTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMA LERVPADIRAAGGVARMADPTIVEEVMNAVSIPVMAKARIGHIVEARVLEAMGVDYID ESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEA VRHMRKVNAQVRKVVAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATP ADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYKLIAELSKELGTAMK GIEISNLLPEQRMQERGW*" /label="pdxS CDS" gene 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /label="pdxS gene" S_feature complement(18785..19514) /Source="Nicolas_S_feature" /locus_tag="new_19194_19923_c" /HighExp="S6, S8, S7, S5, S4, C30, S3, BT, C90, Gly" /AntisenseName="pdxS" /AntisenseCor="-0.65390240445415004" /AntisenseRegPval="-33.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S13" promotor_-10 complement(19502..19520) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(19514) /Source="Nicolas_upshifts" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(19536..19541) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-35" CDS 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 14762015, 15771487, 17144654, 18271580, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 14762015, 15771487, 17144654, 18271580, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, glutamine amidotransferase subunit PdxT" /protein_id="NP_387893.1" /db_xref="EnsemblGenomes-Gn:BSU00120" /db_xref="EnsemblGenomes-Tr:CAB11788" /db_xref="GOA:P37528" /db_xref="InterPro:IPR002161" /db_xref="InterPro:IPR021196" /db_xref="InterPro:IPR029062" /db_xref="PDB:1R9G" /db_xref="PDB:2NV0" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10076" /db_xref="UniProtKB/Swiss-Prot:P37528" /translation="MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLIL PGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNV VVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAK QGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV*" /label="pdxT CDS" gene 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /label="pdxT gene" misc_RNA 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /product="T-box riboswitch specific of serine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboS RNA" gene 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /label="tboS gene" downshifts 20379 /Source="Nicolas_upshifts" /id="D6" /incds=0 /nref=9 /ntot=80 /MaxReadThrough="7.14793" /MaxDrop="4.37654" /score="41.1243331" /energy="-23.3" /TU="U13,U15" /idTUdmin="U13" /TUdmin="-1347" /isTUend="FALSE" /label="downshifts" CDS 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /EC_number="6.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10546897, 12682299, 14732487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10546897, 12682299, 14732487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="seryl-tRNA synthetase" /protein_id="NP_387894.1" /db_xref="EnsemblGenomes-Gn:BSU00130" /db_xref="EnsemblGenomes-Tr:CAB11789" /db_xref="GOA:P37464" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002317" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR015866" /db_xref="InterPro:IPR033729" /db_xref="SubtiList:BG10077" /db_xref="UniProtKB/Swiss-Prot:P37464" /translation="MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGK VEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILL SIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTG SRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDA FKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLI RQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKK YDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRT VAAILENYQQEDGSVVIPKVLRPYMGNREVMKP*" /label="serS CDS" gene 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /label="serS gene" downshifts 21726 /Source="Nicolas_upshifts" /id="D7" /incds=0 /nref=234 /ntot=255 /MaxReadThrough="0.83411" /MaxDrop="7.38039" /score="17.6549558" /energy="-13.3" /TU="NA" /idTUdmin="U13" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 21837..21844 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 21859..21878 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 21859 /Source="Nicolas_upshifts" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="upshifts" tRNA 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(UGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Ser1 tRNA" gene 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /label="trnSL-Ser1 gene" downshifts 21998 /Source="Nicolas_upshifts" /id="D8" /incds=0 /nref=168 /ntot=196 /MaxReadThrough="5.02201" /MaxDrop="8.36635" /score="29.7083093" /energy="-12.4" /TU="U17" /idTUdmin="U13" /TUdmin=272 /isTUend="FALSE" /label="downshifts" S_feature 22043..22120 /Source="Nicolas_S_feature" /locus_tag="new_22452_22529" /HighExp="Cold, H2O2, G180, Paraq, Oxctl, C30, G150, G135, BMM, Heat" /AntisenseName="dck" /AntisenseCor="0.61769771609764101" /AntisenseRegPval="-29" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S14" CDS complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /EC_number="2.7.1.76" /EC_number="2.7.1.74" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6251049, 11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6251049, 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyadenosine/deoxycytidine kinase" /protein_id="NP_387895.1" /db_xref="EnsemblGenomes-Gn:BSU00140" /db_xref="EnsemblGenomes-Tr:CAB11790" /db_xref="GOA:P37529" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10078" /db_xref="UniProtKB/Swiss-Prot:P37529" /translation="MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDH NPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHA DKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK* " /label="dck CDS" gene complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /label="dck gene" promotor_-35 22106..22112 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(22111) /Source="Nicolas_upshifts" /id="D9" /incds=0 /nref=88 /ntot=213 /MaxReadThrough="1.96668" /MaxDrop="4.49235" /score="14.5948578" /energy="-11" /TU="NA" /idTUdmin="U19" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 22122..22758 /Source="Nicolas_S_feature" /locus_tag="new_22531_23167" /HighExp="G180, G135, Cold, C30, Paraq, H2O2, Oxctl, G150, S5, S6" /AntisenseName="dck" /AntisenseCor="0.15155468296621499" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S15" upshifts 22122 /Source="Nicolas_upshifts" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 22126..22137 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /EC_number="2.7.1.113" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyguanosine kinase" /protein_id="NP_387896.1" /db_xref="EnsemblGenomes-Gn:BSU00150" /db_xref="EnsemblGenomes-Tr:CAB11791" /db_xref="GOA:P37530" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10079" /db_xref="UniProtKB/Swiss-Prot:P37530" /translation="MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLD KFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSP HQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLIS DYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV*" /label="dgk CDS" gene complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /label="dgk gene" promotor_-10 complement(23401..23420) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(23419) /Source="Nicolas_upshifts" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(23436..23440) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /EC_number="3.2.1.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11011148, 11737650, 12177332, 10419957, 18456807, 18835992, 19933362, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore peptidoglycan N-acetylglucosaminidase" /protein_id="NP_387897.1" /db_xref="EnsemblGenomes-Gn:BSU00160" /db_xref="EnsemblGenomes-Tr:CAB11792" /db_xref="GOA:P37531" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10080" /db_xref="UniProtKB/Swiss-Prot:P37531" /translation="MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPI AGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESN AYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNT TLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQ DREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLM TYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPA RAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIK ELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR*" /label="sleL CDS" gene complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /label="sleL gene" downshifts complement(23496) /Source="Nicolas_upshifts" /id="D10" /incds=0 /nref=40 /ntot=61 /MaxReadThrough="1.17442" /MaxDrop="6.30997" /score="3.66560192" /energy="-8.4" /TU="NA" /idTUdmin="U20" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(24773..24791) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(24794) /Source="Nicolas_upshifts" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(24807..24812) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2521622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidase (isochorismatase family)" /protein_id="NP_387898.1" /db_xref="EnsemblGenomes-Gn:BSU00170" /db_xref="EnsemblGenomes-Tr:CAB11793" /db_xref="GOA:P37532" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG10081" /db_xref="UniProtKB/Swiss-Prot:P37532" /translation="MSKADKALLIVDMINNFEFDMGETLAKKTEKIVPHILSLKEHAR QNEWPIIYINDHYGLWQADIKNIQQECTNERSKDIITKIAPVDADYFLIKPKHSAFYE TALHTLLTELQVRHIIITGIAGNICVLFTANDAYMREYSITIPKDCIASNSDEDNEFA LTMMENVLFAEITTEEQIIEK*" /label="yaaI CDS" gene complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /label="yaaI gene" promotor_-35 25223..25227 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25242..25261 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" S_feature 25246..25442 /Source="Nicolas_S_feature" /locus_tag="new_25655_25851" /HighExp="Diami, dia5, H2O2, dia15, T0.30H, T-0.40H, HiOs, T-1.10H, Salt, T0.0H" /AntisenseName="yaaI" /AntisenseCor="9.6546810160837798E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S16" upshifts 25248 /Source="Nicolas_upshifts" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" promotor_-10 complement(25382..25400) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25401) /Source="Nicolas_upshifts" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(25415..25421) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /EC_number="3.5.4.33" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15677468, 16014871, 16415880, 16700551, 23658230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA specific adenosine A34 deaminase" /protein_id="NP_387899.1" /db_xref="EnsemblGenomes-Gn:BSU00180" /db_xref="EnsemblGenomes-Tr:CAB11794" /db_xref="GOA:P21335" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR028883" /db_xref="SubtiList:BG10082" /db_xref="UniProtKB/Swiss-Prot:P21335" /translation="MTQDELYMKEAIKEAKKAEEKGEVPIGAVLVINGEIIARAHNLR ETEQRSIAHAEMLVIDEACKALGTWRLEGATLYVTLEPCPMCAGAVVLSRVEKVVFGA FDPKGGCSGTLMNLLQEERFNHQAEVVSGVLEEECGGMLSAFFRELRKKKKAARKNLS E*" /label="tadA CDS" gene 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /label="tadA gene" promotor_-35 25932..25938 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25952..25971 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" misc_RNA 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /product="small cytoplasmic RNA (scRNA, 4.5S RNA), signal recognition particle-like (SRP) component" /experiment="publication(s) with functional evidences, PMID:1372600, 1689715" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1372600, 1689715" /label="scr RNA" gene 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /label="scr gene" S_feature 25974..26123 /Source="Nicolas_S_feature" /locus_tag="new_26383_26532" /HighExp="T1.0H, T5.0H, T1.30H, T3.30H, T3.0H, T2.30H, T4.0H, S8, T-1.10H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S17" upshifts 25974 /Source="Nicolas_upshifts" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" S_feature 26227..26322 /Source="Nicolas_S_feature" /locus_tag="new_26636_26731" /HighExp="S8, Sw, B60, B36, T2.30H, T3.30H, T1.0H, BC, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S18" downshifts 26279 /Source="Nicolas_upshifts" /id="D11" /incds=0 /nref=273 /ntot=278 /MaxReadThrough="4.46774" /MaxDrop="8.31255" /score="23.257527" /energy="-10.3" /TU="U21,U23" /idTUdmin="U21" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 26343..26346 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 26361..26380 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 26370 /Source="Nicolas_upshifts" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III subunit tau subunit" /protein_id="NP_387900.2" /db_xref="EnsemblGenomes-Gn:BSU00190" /db_xref="EnsemblGenomes-Tr:CAB11795" /db_xref="GOA:P09122" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR012763" /db_xref="InterPro:IPR022754" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10083" /db_xref="UniProtKB/Swiss-Prot:P09122" /translation="MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFS GPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVD EIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPH KIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDAL SLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGK DPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILN KSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTG IKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQ QNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKR MDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD*" /label="dnaX CDS" gene 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /label="dnaX gene" promotor_-35 27937..27944 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 27959..27978 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 27974 /Source="Nicolas_upshifts" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16740939, 19208644, 19594923, 20639362, 22333191, 22544270; Product type f : factor" /codon_start=1 /transl_table=11 /product="nucleoid associated protein" /protein_id="NP_387901.1" /db_xref="EnsemblGenomes-Gn:BSU00200" /db_xref="EnsemblGenomes-Tr:CAB11796" /db_xref="GOA:P24281" /db_xref="InterPro:IPR004401" /db_xref="InterPro:IPR036894" /db_xref="SubtiList:BG10084" /db_xref="UniProtKB/Swiss-Prot:P24281" /translation="MRGGMGNMQKMMKQMQKMQKDMAKAQEELAEKVVEGTAGGGMVT VKANGQKEILDVIIKEEVVDPEDIDMLQDLVLAATNEALKKVDEITNETMGQFTKGMN MPGLF*" /label="ebfC CDS" gene 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /label="ebfC gene" CDS 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12065426, 24285298, 24891441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065426, 24285298, 24891441; Product type f: factor" /codon_start=1 /transl_table=11 /product="recA filament-DNA complex stabilisation factor" /protein_id="NP_387902.1" /db_xref="EnsemblGenomes-Gn:BSU00210" /db_xref="EnsemblGenomes-Tr:CAB11797" /db_xref="GOA:P24277" /db_xref="InterPro:IPR000093" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR015967" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR023627" /db_xref="InterPro:IPR023628" /db_xref="InterPro:IPR034137" /db_xref="SubtiList:BG10085" /db_xref="UniProtKB/Swiss-Prot:P24277" /translation="MQYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLGMKEDVVLDFA KALVNAKRNLTYCSVCGHITDQDPCYICEDTRRDKSVICVVQDPKDVIAMEKMKEYNG QYHVLHGAISPMDGIGPEDIKIPELLKRLQDDQVTEVILATNPNIEGEATAMYISRLL KPSGIKLSRIAHGLPVGGDLEYADEVTLSKALEGRREL*" /label="recR CDS" gene 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /label="recR gene" CDS 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387903.1" /db_xref="EnsemblGenomes-Gn:BSU00220" /db_xref="EnsemblGenomes-Tr:CAB11798" /db_xref="InterPro:IPR019644" /db_xref="SubtiList:BG10086" /db_xref="UniProtKB/Swiss-Prot:P37533" /translation="MGFLRKKTLRREFDEKLTEQLFKQKEEWNRQKKLVEKSLEPSAE VLYELKVAEAKYFFYLREAKQRNLKISRWK*" /label="yaaL CDS" gene 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /label="yaaL gene" promotor_-35 29299..29304 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-35" upshifts 29316 /Source="Nicolas_upshifts" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="upshifts" promotor_-10 29320..29338 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-10" CDS 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15087499, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15087499, 17557826; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the pro-sigma(K) processing machinery" /protein_id="NP_387904.2" /db_xref="EnsemblGenomes-Gn:BSU00230" /db_xref="EnsemblGenomes-Tr:CAB11799" /db_xref="GOA:P24282" /db_xref="InterPro:IPR010001" /db_xref="SubtiList:BG10087" /db_xref="UniProtKB/Swiss-Prot:P24282" /translation="MEPIFIIGIILGLVILLFLSGSAAKPLKWIGITAVKFVAGALLL VCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII*" /label="bofA CDS" gene 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /label="bofA gene" promotor_-35 29639..29646 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 29660..29679 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 29667..29869 /Source="Nicolas_S_feature" /locus_tag="new_30076_30278" /HighExp="LBGstat, Diami, C30, H2O2, Oxctl, HPh, BMM, GM 120, Paraq, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.899, 0.99" /label="S19" upshifts 29667 /Source="Nicolas_upshifts" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-16S" gene 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /label="rrnA-16S gene" tRNA 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ile(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ile" gene 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /label="trnA-Ile gene" tRNA 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ala" gene 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /label="trnA-Ala gene" rRNA 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-23S" gene 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /label="rrnA-23S gene" S_feature 34695..34827 /Source="Nicolas_S_feature" /locus_tag="new_35104_35236" /HighExp="LBGstat, G135, Oxctl, C30, HPh, Paraq, G180, LPh, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S20" rRNA 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-5S" gene 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /label="rrnA-5S gene" S_feature 34947..35049 /Source="Nicolas_S_feature" /locus_tag="new_35356_35458" /HighExp="Oxctl, Paraq, H2O2, LBGstat, C30, G180, Cold, G135, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S21" promotor_-35 35010..35018 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-35" promotor_-10 35032..35051 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-10" upshifts 35051 /Source="Nicolas_upshifts" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="upshifts" CDS 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8759874, 15044948, 21935351, 26929302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759874, 15044948, 21935351, 26929302; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="forespore-specific anti-sigma factor" /protein_id="NP_387905.1" /db_xref="EnsemblGenomes-Gn:BSU00240" /db_xref="EnsemblGenomes-Tr:CAB11800" /db_xref="GOA:P37534" /db_xref="InterPro:IPR019700" /db_xref="SubtiList:BG10088" /db_xref="UniProtKB/Swiss-Prot:P37534" /translation="MDETVKLNHTCVICDQEKNRGIHLYTKFICLDCERKVISTSTSD PDYAFYVKKLKSIHTPPLYS*" /label="csfB CDS" gene 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /label="csfB gene" downshifts 35300 /Source="Nicolas_upshifts" /id="D12" /incds=0 /nref=79 /ntot=215 /MaxReadThrough="5.37774" /MaxDrop="4.42494" /score="22.3916007" /energy="-6.7" /TU="U28" /idTUdmin="U27" /TUdmin=3938 /isTUend="FALSE" /label="downshifts" promotor_-35 35361..35370 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 35382..35397 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 35388 /Source="Nicolas_upshifts" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23155385; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatase" /protein_id="NP_387906.1" /db_xref="EnsemblGenomes-Gn:BSU00250" /db_xref="EnsemblGenomes-Tr:CAB11801" /db_xref="GOA:P37467" /db_xref="InterPro:IPR018770" /db_xref="SubtiList:BG10089" /db_xref="UniProtKB/Swiss-Prot:P37467" /translation="MQRFFHFLVWSLTSSATFVFIGILSFFGLNQSIFLSIVYGLASG AAVYIAGIWNARRLFLKKHELTGREYAYIKKNLEEARQKMVRLRKALFQAKSIQMFKQ NAEMLRIVRRIYLLTKKEPKRFYQAERFFYQTLDSVVELTEKYAFLSSHPKKSKELSM SLSETRITLTELTKRLEEDLTQAMGDEIDELQFELDAAKHSLKK*" /label="xpaC CDS" gene 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /label="xpaC gene" CDS 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12533473, 20713661" /codon_start=1 /transl_table=11 /product="putative toxic compound resistance protein" /protein_id="NP_387907.1" /db_xref="EnsemblGenomes-Gn:BSU00260" /db_xref="EnsemblGenomes-Tr:CAB11802" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG10090" /db_xref="UniProtKB/Swiss-Prot:P37535" /translation="MNRDQSDLHIDELLADPFGGNIEIPGSEAVKAEKEQVRLVDVLP EENKEKAIQLAGQIDHKNMQSIVLYGSQAQSKLLNFSHDMINHVQKKDVGEIGEILGE LMKKLEQVNPDDLQSKKKGFLARMFGRVSSSLQEVLSKYQKTSVQIDRISLKLEHSKN ALISDNKLLEQLYEKNKEYFAALNVYIAAGELKLEELKTKTIPELKQQAESSDHNQMA VQEVNDLIQFADRLDKRVHDLLLSRQITIQSAPQIRLIQNTNQALAEKIQSSIVTAIP LWKNQVAIALTLLRQRNAVDAQQKVSDTTNELLLKNAELLKTNTIETARANERGLVDI DTLKKVQESLISTLEETLTIQEEGRIKRRQAEEELMMMEGDLKQKLITIKER*" /label="yaaN CDS" gene 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /label="yaaN gene" S_feature 37230..37310 /Source="Nicolas_S_feature" /locus_tag="new_37639_37719" /HighExp="T0.0H, T-0.40H, T0.30H, T-1.10H, T-1.40H, Salt, T1.0H, G150, Diami, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="0.984, 0.715" /TUlongSig="NA" /TUlongPSig="NA" /label="S22" CDS 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9723923, 20876533, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative decarboxylase" /protein_id="NP_387908.1" /db_xref="EnsemblGenomes-Gn:BSU00270" /db_xref="EnsemblGenomes-Tr:CAB11803" /db_xref="GOA:P37536" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10091" /db_xref="UniProtKB/Swiss-Prot:P37536" /translation="MNTPLYKALIQHARRNSHSFHVPGHHNGDVFFDDAKSIFDPLLT IDVTELAGLDDLHHPSGVIKEAQELASQLYGSAESFFLVNGTTVGNLAMILSVCEPGD TILVQRNCHKSVFHAVDLSGAEPVYLAPDVDSAMHVPTHVPLGTIKEALEAYPDAKGL VLTNPTYYGHSADLTEIITEAHHYGIPVLVDEAHGAHFILGEPFPVSALKMGADIVVQ SAHKTLPAMTMGSYLHLNSSCRINRDRVAEYLNRLQSSSPSYPIMASLDIARAYVQHI IEEQKLSDILQRIETLKQTFDSLTNAEAVNPANPLIITDPLKLTIRSKRGHSGYTLQS ILERANIFTELADENQVLLVLPLGGKRRINAEIIRSIDEEIEKTPPDQTFVSAEWGVQ PVTVLPYPKKVLHSFKKEYVSFEEAAGRLNAEDIIPYPPGIPMIMAGERITKESVQKL SRLISMKTHVQGNMKIKEKQLLVYIEEEKS*" /label="yaaO CDS" gene 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /label="yaaO gene" promotor_-35 38673..38679 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-35" promotor_-10 38694..38712 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-10" upshifts 38703 /Source="Nicolas_upshifts" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="upshifts" CDS 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /EC_number="2.7.4.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696781, 12682299, 18523102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696781, 12682299, 18523102; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="NP_387909.2" /db_xref="EnsemblGenomes-Gn:BSU00280" /db_xref="EnsemblGenomes-Tr:CAB11804" /db_xref="GOA:P37537" /db_xref="InterPro:IPR018094" /db_xref="InterPro:IPR018095" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10092" /db_xref="UniProtKB/Swiss-Prot:P37537" /translation="MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGID IAEQIREVILNENNILMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSSL AYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLE KLDFHTKVQEGYQELMKRFPERFHSVDAGQSKDLVVQDVLKVIDEALKKIQL*" /label="tmk CDS" gene 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /label="tmk gene" promotor_-35 39383..39390 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 39403..39422 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 39414 /Source="Nicolas_upshifts" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /experiment="publication(s) with functional evidences, PMID:10913081, 25433025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 25433025; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal transduction receptor, cyclic di-AMP binding" /protein_id="NP_387910.1" /db_xref="EnsemblGenomes-Gn:BSU00290" /db_xref="EnsemblGenomes-Tr:CAB11805" /db_xref="InterPro:IPR010375" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="PDB:4RLE" /db_xref="SubtiList:BG10093" /db_xref="UniProtKB/Swiss-Prot:P37538" /translation="MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTF MIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLP VDEFHQF*" /label="darA CDS" gene 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /label="darA gene" CDS 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387911.1" /db_xref="EnsemblGenomes-Gn:BSU00300" /db_xref="EnsemblGenomes-Tr:CAB11806" /db_xref="InterPro:IPR005585" /db_xref="InterPro:IPR024042" /db_xref="SubtiList:BG10094" /db_xref="UniProtKB/Swiss-Prot:P37539" /translation="MKINKDIRTFIDNKQIPSVKTSEITASFKTSMENQSSKMKLDQL TRLLSDIEAFGKRLTKSRNFKDLARFKGLVKRFVKEAVDSGLSHETSKSFDLYGNSRT LGLVKEIDDKLIQLTEEMMDQEKPAIDLLERIGEIKGLLINLYT*" /label="yaaR CDS" gene 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /label="yaaR gene" CDS 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8509334, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509334, 12060778, 12682299, 22333191, 23525462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III clamp loader delta' subunit" /protein_id="NP_387912.1" /db_xref="EnsemblGenomes-Gn:BSU00310" /db_xref="EnsemblGenomes-Tr:CAB11807" /db_xref="GOA:P37540" /db_xref="InterPro:IPR004622" /db_xref="InterPro:IPR015199" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10095" /db_xref="UniProtKB/Swiss-Prot:P37540" /translation="MAISWKEMNELQPRVMKLLYNSIEKDRLSHAYLFEGKKGTGKLD AALLLAKSFFCLEGGAEPCESCRNCKRIESGNHPDLHLVQPDGLSIKKAQIQALQEEF SKTGLESHKKLYIISHADQMTANAANSLLKFLEEPNKDTMAVLITEQPQRLLDTIISR CQTLPFQPLQPKAIEDRLIEQDVSPHMARLLANMTNNVAEAVELSRNDEFAESRAKVI KLYEVLHQRKGHAFFFIQDQWMPFFKEKTHQEMGLDMLLLIYRDVLSIQIGNEDKLIY QDLFQSIKQHALQSTQQSVTNQILAVLEAKKRLHSNVNVQGLMEHLVLMLQEG*" /label="holB CDS" gene 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /label="holB gene" CDS 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12270811, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12270811, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex of RNaseY (RicAFT complex /FAD / two [4Fe-4S]2+)" /protein_id="NP_387913.1" /db_xref="EnsemblGenomes-Gn:BSU00320" /db_xref="EnsemblGenomes-Tr:CAB11808" /db_xref="GOA:P37541" /db_xref="InterPro:IPR007557" /db_xref="SubtiList:BG10096" /db_xref="UniProtKB/Swiss-Prot:P37541" /translation="MYNVIGVRFKKAGKIYYFDPNGFHIEHDSCVIVETVRGVEYGQV VIANKQVDEHDVVLPLRKVIRVADDRDLLIVEENKQEALSAFDICQKKVIEHGLDMKL VDVEFTFDRNKVIFYFTADGRVDFRELVKDLASIFKTRIELRQIGVRDEAKMLGGIGP CGRMLCCSTFLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYENDEYETAKEQ LPDIGEMITTANGPAKVVGLNILERVLQVELINREKVIEYTWEELLEEGVVSAQTTD* " /label="ricT CDS" gene 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /label="ricT gene" CDS 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15927750, 16461910, 19737352, 21895792, 23909787, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15927750, 16461910, 19737352, 21895792, 23909787, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="subunit of the DNA replication complex" /protein_id="NP_387914.1" /db_xref="EnsemblGenomes-Gn:BSU00330" /db_xref="EnsemblGenomes-Tr:CAB11809" /db_xref="GOA:P37542" /db_xref="InterPro:IPR010377" /db_xref="PDB:5DOL" /db_xref="SubtiList:BG10097" /db_xref="UniProtKB/Swiss-Prot:P37542" /translation="MDKKELFDTVINLEEQIGSLYRQLGDLKQHIGEMIEENHHLQLE NKHLRKRLDDTTQQIEKFKADKKESKTQKTEQTDIGEGYDNLARLYQEGFHICNVHYG SVRKEDCLFCLSFLNKK*" /label="dnaH CDS" gene 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /label="dnaH gene" CDS 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /EC_number="2.1.1.223" /function="10.3: tRNA and rRNA base modification" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22905870, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase" /protein_id="NP_387915.1" /db_xref="EnsemblGenomes-Gn:BSU00340" /db_xref="EnsemblGenomes-Tr:CAB11810" /db_xref="GOA:P37543" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10098" /db_xref="UniProtKB/Swiss-Prot:P37543" /translation="MVSLHDDERLDYLLAEDMKIIQSPTVFAFSLDAVLLSKFAYVPI QKGKIVDLCTGNGIVPLLLSTRSKADILGVEIQERLHDMAVRSVEYNKLDDQIQIIHD DLKNMPEKLGHNRYDVVTCNPPYFKTPKQTEQNMNEHLRIARHEIHCTLEDVISVSSK LLKQGGKAALVHRPGRLLEIFELMKAYQIEPKRVQFVYPKQGKEANTILVEGIKGGRP DLKILPPLFVYDEQNEYTKEIRTILYGDK*" /label="trmNF CDS" gene 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /label="trmNF gene" CDS 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11483577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UvrC-Intron-type (URI) endonuclease" /protein_id="NP_387916.1" /db_xref="EnsemblGenomes-Gn:BSU00350" /db_xref="EnsemblGenomes-Tr:CAB11811" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG12700" /db_xref="UniProtKB/Swiss-Prot:O31414" /translation="METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKV RRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL*" /label="yazA CDS" gene 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /label="yazA gene" CDS 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /EC_number="2.1.1.198" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 19965768, 25893373; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA 2'-O-ribose C1402 methyltransferase" /protein_id="NP_387917.1" /db_xref="EnsemblGenomes-Gn:BSU00360" /db_xref="EnsemblGenomes-Tr:CAB11812" /db_xref="GOA:P37544" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR008189" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR018063" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10099" /db_xref="UniProtKB/Swiss-Prot:P37544" /translation="MLRRQMSFNGKSDMGILYLVPTPIGNLEDMTFRAIDTLKSVDAI AAEDTRQTKKLCHVYEIETPLVSYHEHNKESSGHKIIEWLKSGKNIALVSDAGLPTIS DPGAEIVKDFTDIGGYVVPLPGANAALTALIASGIVPQPFFFYGFLNRQKKEKKKELE ALKKRQETIIFYEAPHRLKETLSAMAEILGDREIAVTRELTKKYEEFIRGTISEVIGW ANEDQIRGEFCLVVEGSNNEEVDEEEQWWETLTAKEHVEHYISKGATSKEAIKKAAVD RNVPKREVYDAYHIKQ*" /label="rsmI CDS" gene 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /label="rsmI gene" downshifts 44363 /Source="Nicolas_upshifts" /id="D13" /incds=0 /nref=23 /ntot=177 /MaxReadThrough="3.33195" /MaxDrop="3.72723" /score="5.97354542" /energy="-10.2" /TU="U29,U31" /idTUdmin="U29" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for transition state genes (AbrB-SurF)" /protein_id="NP_387918.1" /db_xref="EnsemblGenomes-Gn:BSU00370" /db_xref="EnsemblGenomes-Tr:CAB11813" /db_xref="GOA:P08874" /db_xref="InterPro:IPR007159" /db_xref="PDB:1YFB" /db_xref="PDB:1YSF" /db_xref="PDB:1Z0R" /db_xref="PDB:2K1N" /db_xref="PDB:2MJG" /db_xref="PDB:2RO4" /db_xref="SubtiList:BG10100" /db_xref="UniProtKB/Swiss-Prot:P08874" /translation="MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEK IILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK*" /label="abrB CDS" gene complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /label="abrB gene" downshifts complement(44441) /Source="Nicolas_upshifts" /id="D14" /incds=0 /nref=216 /ntot=263 /MaxReadThrough="2.17237" /MaxDrop="7.75729" /score="20.9582436" /energy="-10.2" /TU="U32" /idTUdmin="U32" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 44760 /Source="Nicolas_upshifts" /id="D15" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="2.53543" /MaxDrop="4.31699" /score="13.7153159" /energy="-14.4" /TU="NA" /idTUdmin="U29" /TUdmin=374 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(44796..44815) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(44813) /Source="Nicolas_upshifts" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(44815..44990) /Source="Nicolas_S_feature" /locus_tag="new_45224_45399_c" /HighExp="C30, H2O2, G180, Etha, S0, GM 25, Gly, G135, MG 25, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S23" promotor_-35 complement(44829..44836) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(44986..45005) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-10" upshifts complement(44990) /Source="Nicolas_upshifts" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="upshifts" promotor_-35 complement(45019..45026) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-35" promotor_-35 45090..45094 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-35" promotor_-10 45109..45128 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-10" S_feature 45115..45223 /Source="Nicolas_S_feature" /locus_tag="new_45524_45632" /HighExp="LBGtran, Heat, dia5, dia15, LBGexp, Lbexp, dia0, H2O2, Diami, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S24" upshifts 45115 /Source="Nicolas_upshifts" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="upshifts" CDS 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /EC_number="6.1.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11233169, 12682299, 12792655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA synthetase" /protein_id="NP_387919.1" /db_xref="EnsemblGenomes-Gn:BSU00380" /db_xref="EnsemblGenomes-Tr:CAB11814" /db_xref="GOA:P37465" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004495" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014758" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR023457" /db_xref="InterPro:IPR033911" /db_xref="SubtiList:BG10101" /db_xref="UniProtKB/Swiss-Prot:P37465" /translation="MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGF DVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKR HKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPD SGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAV SRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEI VRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDEL RYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGA VTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDP AKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQL KDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFM DVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTN LKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK*" /label="metS CDS" gene 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /label="metS gene" promotor_-10 complement(45972..45991) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(45980) /Source="Nicolas_upshifts" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(46007..46011) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 47202 /Source="Nicolas_upshifts" /id="D16" /incds=0 /nref=18 /ntot=206 /MaxReadThrough="4.8491" /MaxDrop="2.9167" /score="13.7153159" /energy="-14.4" /TU="U34" /idTUdmin="U34" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" S_feature complement(47264..49610) /Source="Nicolas_S_feature" /locus_tag="new_47673_50019_c" /HighExp="T0.30H, T1.0H, T1.30H, Salt, C30, T2.0H, T-0.40H, T0.0H, T2.30H, T-1.10H" /AntisenseName="yabE" /AntisenseCor="-0.28154713646185298" /AntisenseRegPval="-5.6" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S25" CDS 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10747959, 16014871, 16461678, 19332551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acyl-tRNA deacylase" /protein_id="NP_387920.1" /db_xref="EnsemblGenomes-Gn:BSU00390" /db_xref="EnsemblGenomes-Tr:CAB11815" /db_xref="GOA:P37545" /db_xref="InterPro:IPR001130" /db_xref="InterPro:IPR015991" /db_xref="InterPro:IPR018228" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10102" /db_xref="UniProtKB/Swiss-Prot:P37545" /translation="MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTIT RAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKS PKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAE VARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNE PSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN*" /label="dayD CDS" gene 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /label="dayD gene" S_feature 48065..48145 /Source="Nicolas_S_feature" /locus_tag="new_48474_48554" /HighExp="Heat, C30, LBGtran, LBGstat, C90, Etha, M40t45, LPhT, MG 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S26" promotor_-35 48122..48127 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 48143..48161 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 48147 /Source="Nicolas_upshifts" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 48172..48175 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-35" promotor_-10 48190..48209 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-10" upshifts 48207 /Source="Nicolas_upshifts" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="upshifts" CDS 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15774001, 19047346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall shaping enzyme" /protein_id="NP_387921.1" /db_xref="EnsemblGenomes-Gn:BSU00400" /db_xref="EnsemblGenomes-Tr:CAB11816" /db_xref="GOA:P37546" /db_xref="InterPro:IPR007137" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR011098" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG10103" /db_xref="UniProtKB/Swiss-Prot:P37546" /translation="MGEREGRVDSLLDTLYNLSEEKEAFFITQKMKKLFSVKLSKSKV ILVAACLLLAGSGTAYAAHELTKQSVSVSINGKKKHIRTHANTVGDLLETLDIKTRDE DKITPAKQTKITADMDVVYEAAKPVKLTINGEEKTLWSTAKTVGALLDEQDVDVKEQD QIDPAIDTDISKDMKINIEPAFQVTVNDAGKQKKIWTTSTTVADFLKQQKMNIKDEDK IKPALDAKLTKGKADITITRIEKVTDVVEEKIAFDVKKQEDASLEKGKEKVVQKGKEG KLKKHFEVVKENGKEVSRELVKEETAEQSKDKVIAVGTKQSSPKFETVSASGDSKTVV SRSNESTGKVMTVSSTAYTASCSGCSGHTATGVNLKNNPNAKVIAVDPNVIPLGSKVH VEGYGYAIAADTGSAIKGNKIDVFFPEKSSAYRWGNKTVKIKILN*" /label="yabE CDS" gene 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /label="yabE gene" promotor_-35 48240..48247 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 48258 /Source="Nicolas_upshifts" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 48262..48281 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 49494 /Source="Nicolas_upshifts" /id="D17" /incds=0 /nref=87 /ntot=220 /MaxReadThrough="5.02755" /MaxDrop="4.87493" /score="27.529638" /energy="-11.3" /TU="U36,U37,U38" /idTUdmin="U34" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-35 49556..49560 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 49576..49595 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 49578..49677 /Source="Nicolas_S_feature" /locus_tag="new_49987_50086" /HighExp="LoTm, H2O2, G180, G135, G150, Paraq, Oxctl, C30, dia15, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.843, 0.943" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S27" upshifts 49578 /Source="Nicolas_upshifts" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(49602..49617) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(49618) /Source="Nicolas_upshifts" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(49629..49638) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 49674..49690 /Source="Nicolas_upshift_promotors" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /EC_number="3.1.26.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11233981, 11976317, 12794188, 16077031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11233981, 11976317, 12794188, 16077031; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease M5" /protein_id="NP_387922.1" /db_xref="EnsemblGenomes-Gn:BSU00410" /db_xref="EnsemblGenomes-Tr:CAB11817" /db_xref="GOA:P37547" /db_xref="InterPro:IPR004466" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR025156" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG10104" /db_xref="UniProtKB/Swiss-Prot:P37547" /translation="MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRL AQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVES IRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQK RLQMFQIKKSDFMSALDTVMREEQNE*" /label="rnmV CDS" gene 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /label="rnmV gene" upshifts 49688 /Source="Nicolas_upshifts" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" CDS 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 99430, 6801425, 11327780, 1690648, 22391551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dimethyladenosine 16S ribosomal RNA transferase" /protein_id="NP_387923.1" /db_xref="EnsemblGenomes-Gn:BSU00420" /db_xref="EnsemblGenomes-Tr:CAB11818" /db_xref="GOA:P37468" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR011530" /db_xref="InterPro:IPR020596" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023165" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10105" /db_xref="UniProtKB/Swiss-Prot:P37468" /translation="MNKDIATPIRTKEILKKYGFSFKKSLGQNFLIDTNILNRIVDHA EVTEKTGVIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILKDTLSPYENVTVIHQD VLKADVKSVIEEQFQDCDEIMVVANLPYYVTTPIIMKLLEEHLPLKGIVVMLQKEVAE RMAADPSSKEYGSLSIAVQFYTEAKTVMIVPKTVFVPQPNVDSAVIRLILRDGPAVDV ENESFFFQLIKASFAQRRKTLLNNLVNNLPEGKAQKSTIEQVLEETNIDGKRRGESLS IEEFAALSNGLYKALF*" /label="rsmA CDS" gene 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /label="rsmA gene" downshifts 51074 /Source="Nicolas_upshifts" /id="D18" /incds=0 /nref=152 /ntot=229 /MaxReadThrough="3.0815" /MaxDrop="4.58632" /score="20.4155562" /energy="-9.4" /TU="NA" /idTUdmin="U36" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 51124..51133 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 51147..51166 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 51149..51270 /Source="Nicolas_S_feature" /locus_tag="new_51558_51679" /HighExp="S7, S6, S8, BT, S5, B36, G/S, Pyr, B60, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S28" upshifts 51149 /Source="Nicolas_upshifts" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="upshifts" CDS 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 11040425, 16751597, 19060142, 19833771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 11040425, 16751597, 19060142, 19833771; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protease" /protein_id="NP_387924.1" /db_xref="EnsemblGenomes-Gn:BSU00430" /db_xref="EnsemblGenomes-Tr:CAB11819" /db_xref="GOA:P37548" /db_xref="InterPro:IPR008764" /db_xref="SubtiList:BG10106" /db_xref="UniProtKB/Swiss-Prot:P37548" /translation="MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRL IADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQE HYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDI LVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFES LIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIE TRGVLRIGMPYKSN*" /label="prtG CDS" gene 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /label="prtG gene" downshifts 52130 /Source="Nicolas_upshifts" /id="D19" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.30424" /MaxDrop="7.1507" /score="26.6672651" /energy="-11.5" /TU="NA" /idTUdmin="U42" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 52240..52310 /Source="Nicolas_S_feature" /locus_tag="new_52649_52719" /HighExp="S8, S5, S7, S6, S4, BT, LoTm, G/S, nit, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S29" promotor_-35 52301..52308 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 52312 /Source="Nicolas_upshifts" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 52322..52341 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(52331..52345) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(52338) /Source="Nicolas_upshifts" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(52354..52358) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12761295, 22720735, 23378512; Producttype ph: phenotype" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387925.1" /db_xref="EnsemblGenomes-Gn:BSU00440" /db_xref="EnsemblGenomes-Tr:CAB11820" /db_xref="GOA:P37466" /db_xref="InterPro:IPR009366" /db_xref="SubtiList:BG10107" /db_xref="UniProtKB/Swiss-Prot:P37466" /translation="MAKTLSDIKRSLDGNLGKRLTLKANGGRRKTIERSGILAETYPS VFVIQLDQDENSFERVSYSYADILTETVELTFNDDAASSVAF*" /label="veg CDS" gene 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /label="veg gene" downshifts 52526 /Source="Nicolas_upshifts" /id="D20" /incds=1 /nref=4 /ntot=158 /MaxReadThrough="8.09861" /MaxDrop="2.7867" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U42" /TUdmin=396 /isTUend="FALSE" /label="downshifts" downshifts 52613 /Source="Nicolas_upshifts" /id="D21" /incds=0 /nref=191 /ntot=264 /MaxReadThrough="5.88511" /MaxDrop="6.03144" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U43" /TUdmin="-331" /isTUend="FALSE" /label="downshifts" promotor_-35 52679..52685 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 52699..52710 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 52702..52773 /Source="Nicolas_S_feature" /locus_tag="new_53111_53182" /HighExp="S8, Cold, S6, S7, ferm, S5, nit, Etha, G135, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S30" upshifts 52702 /Source="Nicolas_upshifts" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="upshifts" CDS 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7959056, 8982008, 11092849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7959056, 8982008, 11092849; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_387926.1" /db_xref="EnsemblGenomes-Gn:BSU00450" /db_xref="EnsemblGenomes-Tr:CAB11821" /db_xref="GOA:P37549" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10108" /db_xref="UniProtKB/Swiss-Prot:P37549" /translation="MGRRRGVMSDEFKYELAKDLGFYDTVKNGGWGEIRARDAGNMVK RAIEIAEQQMAQNQNNR*" /label="sspF CDS" gene 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /label="sspF gene" downshifts 52944 /Source="Nicolas_upshifts" /id="D22" /incds=0 /nref=54 /ntot=153 /MaxReadThrough="2.67408" /MaxDrop="6.21058" /score="38.1065567" /energy="-12.6" /TU="NA" /idTUdmin="U43" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(52954..55308) /Source="Nicolas_S_feature" /locus_tag="new_53363_55717_c" /HighExp="S5, S4, S6, T5.0H, S3, S8, S7, T4.0H, T3.30H, C30" /AntisenseName="ispE" /AntisenseCor="-0.66604185700913698" /AntisenseRegPval="-35.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S31" promotor_-35 53037..53041 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-35" promotor_-10 53057..53076 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-10" upshifts 53060 /Source="Nicolas_upshifts" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="upshifts" CDS 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /EC_number="2.7.1.148" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11361082, 12682299, 12771135, 17458547, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" /protein_id="NP_387927.1" /db_xref="EnsemblGenomes-Gn:BSU00460" /db_xref="EnsemblGenomes-Tr:CAB11822" /db_xref="GOA:P37550" /db_xref="InterPro:IPR004424" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10109" /db_xref="UniProtKB/Swiss-Prot:P37550" /translation="MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELT ELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGG SSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHIST PPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLE SVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQV YAVRMIGEQNALD*" /label="ispE CDS" gene 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /label="ispE gene" CDS 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11591660, 12837783, 12837784, 15629952, 16163456, 27329548" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12837783, 12837784, 15629952, 16163456, 27329548; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine biosynthesis operon (PurR-pRpp)" /protein_id="NP_387928.1" /db_xref="EnsemblGenomes-Gn:BSU00470" /db_xref="EnsemblGenomes-Tr:CAB11823" /db_xref="GOA:P37551" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010078" /db_xref="InterPro:IPR015265" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1O57" /db_xref="PDB:1P4A" /db_xref="SubtiList:BG10110" /db_xref="UniProtKB/Swiss-Prot:P37551" /translation="MKFRRSGRLVDLTNYLLTHPHELIPLTFFSERYESAKSSISEDL TIIKQTFEQQGIGTLLTVPGAAGGVKYIPKMKQAEAEEFVQTLGQSLANPERILPGGY VYLTDILGKPSVLSKVGKLFASVFAEREIDVVMTVATKGIPLAYAAASYLNVPVVIVR KDNKVTEGSTVSINYVSGSSNRIQTMSLAKRSMKTGSNVLIIDDFMKAGGTINGMINL LDEFNANVAGIGVLVEAEGVDERLVDEYMSLLTLSTINMKEKSIEIQNGNFLRFFKDN LLKNGETES*" /label="purR CDS" gene 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /label="purR gene" CDS 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /EC_number="3.5.99.10" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2113912, 12515541, 14729707, 10557275, 10919400, 10368157, 20562306, 23815688; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminoacrylate/iminopropionate hydrolase/deaminase" /protein_id="NP_387929.1" /db_xref="EnsemblGenomes-Gn:BSU00480" /db_xref="EnsemblGenomes-Tr:CAB11824" /db_xref="GOA:P37552" /db_xref="InterPro:IPR006056" /db_xref="InterPro:IPR006175" /db_xref="InterPro:IPR019897" /db_xref="InterPro:IPR035959" /db_xref="PDB:1QD9" /db_xref="SubtiList:BG10111" /db_xref="UniProtKB/Swiss-Prot:P37552" /translation="MTKAVHTKHAPAAIGPYSQGIIVNNMFYSSGQIPLTPSGEMVNG DIKEQTHQVFSNLKAVLEEAGASFETVVKATVFIADMEQFAEVNEVYGQYFDTHKPAR SCVEVARLPKDALVEIEVIALVK*" /label="ridA CDS" gene 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /label="ridA gene" downshifts 55253 /Source="Nicolas_upshifts" /id="D23" /incds=0 /nref=172 /ntot=226 /MaxReadThrough="3.8891" /MaxDrop="4.63425" /score="22.9159767" /energy="-12.3" /TU="U46" /idTUdmin="U46" /TUdmin="-155" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(55297..55315) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 55298..55406 /Source="Nicolas_S_feature" /locus_tag="new_55707_55815" /HighExp="S8, S7, Etha, B36, LoTm, C30, Sw, B60, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S32" upshifts complement(55309) /Source="Nicolas_upshifts" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(55331..55336) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 55386..55394 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-35" promotor_-10 55405..55423 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-10" upshifts 55408 /Source="Nicolas_upshifts" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="upshifts" CDS 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733708, 10348850, 10648512, 16428420, 27048798" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733708, 10348850, 10648512, 16428420, 27048798; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for spore cortex synthesis (stage V sporulation)" /protein_id="NP_387930.1" /db_xref="EnsemblGenomes-Gn:BSU00490" /db_xref="EnsemblGenomes-Tr:CAB11825" /db_xref="GOA:P28015" /db_xref="InterPro:IPR007170" /db_xref="InterPro:IPR036751" /db_xref="PDB:2IA9" /db_xref="SubtiList:BG10112" /db_xref="UniProtKB/Swiss-Prot:P28015" /translation="MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLF VAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS*" /label="spoVG CDS" gene 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /label="spoVG gene" downshifts 55739 /Source="Nicolas_upshifts" /id="D24" /incds=0 /nref=263 /ntot=285 /MaxReadThrough="5.11673" /MaxDrop="7.2673" /score="19.392304" /energy="-22.3" /TU="U48" /idTUdmin="U46" /TUdmin=331 /isTUend="FALSE" /label="downshifts" S_feature 55784..55895 /Source="Nicolas_S_feature" /locus_tag="new_56193_56304" /HighExp="B60, B36, M9-stat, S2, BT, LoTm, Etha, Lbstat, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S33" promotor_-35 55877..55881 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 55897..55916 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 55897 /Source="Nicolas_upshifts" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /EC_number="2.3.1.157" /EC_number="2.7.7.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase" /protein_id="NP_387931.1" /db_xref="EnsemblGenomes-Gn:BSU00500" /db_xref="EnsemblGenomes-Tr:CAB11826" /db_xref="GOA:P14192" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005882" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10113" /db_xref="UniProtKB/Swiss-Prot:P14192" /translation="MDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKL SLSKLVTIVGHGAEEVKKQLGDKSEYALQAKQLGTAHAVKQAQPFLADEKGVTIVICG DTPLLTAETMEQMLKEHTQREAKATILTAVAEDPTGYGRIIRSENGAVQKIVEHKDAS EEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVAAYQT GNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIY PGTVIKGEVQIGEDTIIGPHTEIMNSAIGSRTVIKQSVVNHSKVGNDVNIGPFAHIRP DSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVGTDVNLGCGSITVNYDGKNK YLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYV KNIHKK*" /label="glmU CDS" gene 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /label="glmU gene" downshifts complement(57288) /Source="Nicolas_upshifts" /id="D25" /incds=0 /nref=5 /ntot=84 /MaxReadThrough="2.39379" /MaxDrop="3.65636" /score="-7.65702938" /energy="-13.8" /TU="NA" /idTUdmin="U47" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" CDS 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /EC_number="2.7.6.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2169413, 3038693, 8522540, 22083279, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2169413, 3038693, 8522540, 22083279, 25890046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylpyrophosphate synthetase" /protein_id="NP_387932.1" /db_xref="EnsemblGenomes-Gn:BSU00510" /db_xref="EnsemblGenomes-Tr:CAB11827" /db_xref="GOA:P14193" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR000842" /db_xref="InterPro:IPR005946" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR029099" /db_xref="PDB:1DKR" /db_xref="PDB:1DKU" /db_xref="PDB:1IBS" /db_xref="SubtiList:BG10114" /db_xref="UniProtKB/Swiss-Prot:P14193" /translation="MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDG EVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYAR QDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEY FEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGK TAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVT NSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS*" /label="prs CDS" gene 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /label="prs gene" promotor_-35 58302..58308 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 58321 /Source="Nicolas_upshifts" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 58323..58341 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8522540, 9669336, 10369900, 12432960, 17198710" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8522540, 9669336, 10369900, 12432960, 17198710; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein BL25 (Ctc), binding 5S RNA" /protein_id="NP_387933.1" /db_xref="EnsemblGenomes-Gn:BSU00520" /db_xref="EnsemblGenomes-Tr:CAB11828" /db_xref="GOA:P14194" /db_xref="InterPro:IPR001021" /db_xref="InterPro:IPR011035" /db_xref="InterPro:IPR020056" /db_xref="InterPro:IPR020057" /db_xref="InterPro:IPR029751" /db_xref="InterPro:IPR037121" /db_xref="SubtiList:BG10115" /db_xref="UniProtKB/Swiss-Prot:P14194" /translation="MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDS VELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVE VPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPA GGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ*" /label="ctc CDS" gene 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /label="ctc gene" downshifts 58972 /Source="Nicolas_upshifts" /id="D26" /incds=0 /nref=120 /ntot=249 /MaxReadThrough="8.65206" /MaxDrop="5.4784" /score="1.94770319" /energy="-11.2" /TU="U49,U50" /idTUdmin="U48" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /EC_number="3.1.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8635758, 12100553, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8635758, 12100553, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-tRNA hydrolase" /protein_id="NP_387934.1" /db_xref="EnsemblGenomes-Gn:BSU00530" /db_xref="EnsemblGenomes-Tr:CAB11829" /db_xref="GOA:P37470" /db_xref="InterPro:IPR001328" /db_xref="InterPro:IPR018171" /db_xref="InterPro:IPR036416" /db_xref="SubtiList:BG10116" /db_xref="UniProtKB/Swiss-Prot:P37470" /translation="MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNG LYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRL RTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEE AVDKSVKACEASLSKPFLEVMNEFNAKV*" /label="pth CDS" gene 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /label="pth gene" misc_feature 59274..59277 /Source="Nicolas_upshift_promotors" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 59280 /Source="Nicolas_upshifts" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /experiment="publication(s) with functional evidences, PMID:21037003, 28598017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21037003, 28598017; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein required for the switch from F to G during sporulation (anti sigma F)" /protein_id="NP_387935.1" /db_xref="EnsemblGenomes-Gn:BSU00540" /db_xref="EnsemblGenomes-Tr:CAB11830" /db_xref="GOA:P37553" /db_xref="InterPro:IPR020115" /db_xref="PDB:5MSL" /db_xref="SubtiList:BG10117" /db_xref="UniProtKB/Swiss-Prot:P37553" /translation="MALHYYCRHCGVKVGSLESSMVSTDSLGFQHLTNEERNDMISYK ENGDVHVLTICEDCQEALDRNPHYHEYHTFIQ*" /label="fin CDS" gene 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /label="fin gene" S_feature 59952..60020 /Source="Nicolas_S_feature" /locus_tag="new_60361_60429" /HighExp="Etha, S5, S4, S7, S8, S6, S3, H2O2, Diami, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigB, SigA" /TUshortPSig="0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S34" CDS 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription-repair coupling factor" /protein_id="NP_387936.1" /db_xref="EnsemblGenomes-Gn:BSU00550" /db_xref="EnsemblGenomes-Tr:CAB11831" /db_xref="GOA:P37474" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR004576" /db_xref="InterPro:IPR005118" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG10118" /db_xref="UniProtKB/Swiss-Prot:P37474" /translation="MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSA LANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQ RLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEV GYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETL TSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSE GQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLL EEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQ MNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYI MEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVH INHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLY KLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQE TEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTT ILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKD VVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSV IETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLV PDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKM GLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRD LTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAY IPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVY ARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQ TKGRSADEWLDTVLGMLKGLKDVKKQTISST*" /label="mfd CDS" gene 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /label="mfd gene" promotor_-35 63572..63578 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 63592..63689 /Source="Nicolas_S_feature" /locus_tag="new_64001_64098" /HighExp="S5, S7, S8, S6, S4, Etha, S3, H2O2, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, Sig-, SigB, SigA" /TUshortPSig="1, 0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S35" promotor_-10 63592..63603 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 63592 /Source="Nicolas_upshifts" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of sporulation / germination" /protein_id="NP_387937.1" /db_xref="EnsemblGenomes-Gn:BSU00560" /db_xref="EnsemblGenomes-Tr:CAB11832" /db_xref="GOA:P37554" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR014213" /db_xref="PDB:2RO5" /db_xref="PDB:2W1R" /db_xref="PDB:2W1T" /db_xref="SubtiList:BG10119" /db_xref="UniProtKB/Swiss-Prot:P37554" /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEV ILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEML ERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEV EHKAVETAAGFLARQMEQ*" /label="spoVT CDS" gene 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /label="spoVT gene" downshifts 64230 /Source="Nicolas_upshifts" /id="D27" /incds=0 /nref=236 /ntot=260 /MaxReadThrough="1.92082" /MaxDrop="6.20706" /score="-2.69593259" /energy="-11.6" /TU="NA" /idTUdmin="U49" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 64326..64345 /Source="Nicolas_upshift_promotors" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 64337 /Source="Nicolas_upshifts" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_387938.1" /db_xref="EnsemblGenomes-Gn:BSU00570" /db_xref="EnsemblGenomes-Tr:CAB11833" /db_xref="GOA:P37555" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10120" /db_xref="UniProtKB/Swiss-Prot:P37555" /translation="MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDV GFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLF LCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMT EQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQT DRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCL KGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTG ASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIA VGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIP IIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTD EELNSVPFGSKLSKFMRRREQNGG*" /label="yabM CDS" gene 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /label="yabM gene" promotor_-35 65877..65884 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-35" promotor_-10 65899..65918 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-10" upshifts 65913 /Source="Nicolas_upshifts" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="upshifts" CDS 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11178267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fusion methylase and nucleotide pyrophosphohydrolase" /protein_id="NP_387939.1" /db_xref="EnsemblGenomes-Gn:BSU00580" /db_xref="EnsemblGenomes-Tr:CAB11834" /db_xref="GOA:P37556" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011551" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR024180" /db_xref="InterPro:IPR035013" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10121" /db_xref="UniProtKB/Swiss-Prot:P37556" /translation="MAGKITVVGLGAGDMDQLTIGIHKLLTKADTLYVRTKDHPLIEE LEKETKNIRFFDDIYEKHDQFEAVYEEIADILFEAARREDVVYAVPGHPFVAEKTVQL LTERQEKENVQVKVAGGQSFLDATFNVLQIDPIEGFQFVDAGTLSADELELRHHLIIC QVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSV YIPPIKEEKLLYHEFSTFRSIIRELRGPNGCPWDKKQTHQSLKQYMIEECYELLEAID EEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVIKGISEKMVRRHPHVFKDVKVQ DENDVLANWEDIKKAEKNTSESSLLDSVPKTLPALSKAAKLQKKAAKVGFDWEDVSDI WEKVSEEMKEFSSEVSEAPHEHNLKAEFGDILFALVNVARFYKIEPEEALTMTNDKFR RRFSYIEETAKEEGVELADMSLEDMDKLWNEAKETERRS*" /label="yabN CDS" gene 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /label="yabN gene" promotor_-35 66637..66644 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-35" promotor_-10 66658..66676 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-10" upshifts 66672 /Source="Nicolas_upshifts" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="upshifts" promotor_no_box complement(67060..67160) /Source="Nicolas_upshift_promotors" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(67100) /Source="Nicolas_upshifts" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10675343, 10675344, 19013177; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal RNA binding protein involved in 50S recycling; heat shock protein" /protein_id="NP_387940.1" /db_xref="EnsemblGenomes-Gn:BSU00590" /db_xref="EnsemblGenomes-Tr:CAB11835" /db_xref="GOA:P37557" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR025490" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10122" /db_xref="UniProtKB/Swiss-Prot:P37557" /translation="MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPG DELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEKLGE*" /label="hslR CDS" gene 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /label="hslR gene" promotor_-35 67733..67738 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 67754..67772 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 67772 /Source="Nicolas_upshifts" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(67804) /Source="Nicolas_upshifts" /id="D28" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="1.93659" /MaxDrop="3.17193" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=3014 /isTUend="FALSE" /label="downshifts" CDS 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15231775, 21904870, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15231775, 21904870, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore protein involved in the shaping of the spore coat" /protein_id="NP_387941.1" /db_xref="EnsemblGenomes-Gn:BSU00600" /db_xref="EnsemblGenomes-Tr:CAB11836" /db_xref="GOA:P37558" /db_xref="InterPro:IPR012504" /db_xref="InterPro:IPR022476" /db_xref="SubtiList:BG10123" /db_xref="UniProtKB/Swiss-Prot:P37558" /translation="MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFL LETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK*" /label="spcP CDS" gene 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /label="spcP gene" CDS 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein of the forespore" /protein_id="NP_387942.1" /db_xref="EnsemblGenomes-Gn:BSU00610" /db_xref="EnsemblGenomes-Tr:CAB11837" /db_xref="GOA:P37559" /db_xref="InterPro:IPR014242" /db_xref="InterPro:IPR019074" /db_xref="SubtiList:BG10124" /db_xref="UniProtKB/Swiss-Prot:P37559" /translation="MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIH DILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLV VSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFP IRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR*" /label="spcQ CDS" gene 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /label="spcQ gene" promotor_-35 68611..68620 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68633..68648 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68635 /Source="Nicolas_upshifts" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 68667..68675 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68686..68704 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68696 /Source="Nicolas_upshifts" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_387943.1" /db_xref="EnsemblGenomes-Gn:BSU00620" /db_xref="EnsemblGenomes-Tr:CAB11838" /db_xref="GOA:P37471" /db_xref="InterPro:IPR007060" /db_xref="SubtiList:BG10125" /db_xref="UniProtKB/Swiss-Prot:P37471" /translation="MNFSRERTITEIQNDYKEQVERQNQLKKRRRKGLYRRLTVFGAL VFLTAIVLASSVWSQTSSLSAKEEKKEQLEKELKSLKTKQTDLKEEISKLKDEDYVTE LARRDLFMSGDGEIIFNVEKKSK*" /label="divIC CDS" gene 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /label="divIC gene" CDS 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 15066026, 16014871, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; polyribonucleotide nucleotidyltransferase or phosphorylase" /protein_id="NP_387944.1" /db_xref="EnsemblGenomes-Gn:BSU00630" /db_xref="EnsemblGenomes-Tr:CAB11839" /db_xref="GOA:P37560" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG10126" /db_xref="UniProtKB/Swiss-Prot:P37560" /translation="MSIEVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVADNYVK DINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDRPQARPRNDFRPKESFEQKMNKFL KDSEDRLSSLKRNTESKRGGRGARRG*" /label="yabR CDS" gene 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /label="yabR gene" downshifts 69597 /Source="Nicolas_upshifts" /id="D29" /incds=0 /nref=247 /ntot=274 /MaxReadThrough="3.67278" /MaxDrop="8.3221" /score="23.2738869" /energy="-12.5" /TU="U58" /idTUdmin="U53" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 69711..69718 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69732..69751 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69747 /Source="Nicolas_upshifts" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="upshifts" tRNA 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="methionine transfer RNA (CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Met1 tRNA" gene 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /label="trnSL-Met1 gene" tRNA 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="glutamate transfer RNA (UUC); Evidence 2a: Functionfrom experimental evidences in other organisms; Producttype n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu1 tRNA" gene 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /label="trnSL-Glu1 gene" downshifts 69928 /Source="Nicolas_upshifts" /id="D30" /incds=0 /nref=2 /ntot=58 /MaxReadThrough="4.83761" /MaxDrop="5.55326" /score="25.2769629" /energy="-10.8" /TU="U58,U60" /idTUdmin="U58" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 69973..70084 /Source="Nicolas_S_feature" /locus_tag="new_70382_70493" /HighExp="Cold, G180, C30, G135, G150, Oxctl, Paraq, H2O2, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S36" misc_feature 70080..70099 /Source="Nicolas_upshift_promotors" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 70086 /Source="Nicolas_upshifts" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="upshifts" CDS 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /EC_number="3.1.3.16" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10747015, 12180929, 15126482, 15866939, 15978076, 28358838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10747015, 12180929, 15126482, 15866939, 15978076, 28358838; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="SpoIIAA-phosphate serine phosphatase" /protein_id="NP_387945.1" /db_xref="EnsemblGenomes-Gn:BSU00640" /db_xref="EnsemblGenomes-Tr:CAB11840" /db_xref="GOA:P37475" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014221" /db_xref="InterPro:IPR036457" /db_xref="PDB:3T91" /db_xref="PDB:3T9Q" /db_xref="PDB:5UCG" /db_xref="SubtiList:BG10127" /db_xref="UniProtKB/Swiss-Prot:P37475" /translation="MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGF IYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLL ILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAI VEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQA EHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKE GKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPG TVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLS KITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSK QVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQ EEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQI LVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAA AISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDL SIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDL LIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMT VVVVRIDHNTPKWASIPVPAIFQNKQEIS*" /label="spoIIE CDS" gene 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /label="spoIIE gene" downshifts 70170 /Source="Nicolas_upshifts" /id="D31" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="5.5737" /MaxDrop="3.93473" /score="25.2769629" /energy="-10.8" /TU="U60,U61" /idTUdmin="U58" /TUdmin=44 /isTUend="FALSE" /label="downshifts" S_feature complement(70781..71390) /Source="Nicolas_S_feature" /locus_tag="new_71190_71799_c" /HighExp="S8, S6, S4, S5, S3, S7, M9-stat, T5.0H, LoTm, Pyr" /AntisenseName="spoIIE" /AntisenseCor="0.685558251745638" /AntisenseRegPval="-38" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S37" downshifts complement(70807) /Source="Nicolas_upshifts" /id="D32" /incds=1 /nref=2 /ntot=11 /MaxReadThrough="2.2425" /MaxDrop="4.29972" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(71363..71381) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(71389) /Source="Nicolas_upshifts" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(71397..71402) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 71594..71600 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 71615..71633 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 71622 /Source="Nicolas_upshifts" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 72632..72635 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 72653..72670 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 72656 /Source="Nicolas_upshifts" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="upshifts" CDS 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387946.1" /db_xref="EnsemblGenomes-Gn:BSU00650" /db_xref="EnsemblGenomes-Tr:CAB11841" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG10128" /db_xref="UniProtKB/Swiss-Prot:P37561" /translation="MNNGHLNQILLITDGCSNHGEDPLAMAAFAKEQGITVNVIGIME ENQIDPEAMKEVEGIALAGGGVHQVVYASQLSQTVQMVTKKAMTQTLQGVVNQELKQI LGKNVEMEELSPEKRGEVMEVVDELGETVHLQVLVLVDTSASMAPKLPTVKEALIDLS VSLNSRIGNNEFAMCIFPGKKQEVELVLNWTPKLQSLSTLFAKLSTGGITPTGPAIRE ATLQFEKIRSRRGMLADDERRFDEFGM*" /label="yabS CDS" gene 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /label="yabS gene" CDS 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23634894, 24731262, 25278935" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23634894, 24731262, 25278935; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine-protein kinase" /protein_id="NP_387947.2" /db_xref="EnsemblGenomes-Gn:BSU00660" /db_xref="EnsemblGenomes-Tr:CAB11842" /db_xref="GOA:P37562" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG10129" /db_xref="UniProtKB/Swiss-Prot:P37562" /translation="MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYL AETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSF YAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPP ARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKE FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQ PIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYII FFLI*" /label="prkT CDS" gene 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /label="prkT gene" promotor_-35 73948..73954 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-35" promotor_-10 73970..73988 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-10" upshifts 73976 /Source="Nicolas_upshifts" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="upshifts" promotor_-35 74446..74453 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 74467..74486 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 74477 /Source="Nicolas_upshifts" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /EC_number="6.3.4.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14527414, 16039592, 17005971, 22720735, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14527414, 16039592, 17005971, 22720735, 24001521; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(ile2) lysidine synthetase" /protein_id="NP_387948.1" /db_xref="EnsemblGenomes-Gn:BSU00670" /db_xref="EnsemblGenomes-Tr:CAB11843" /db_xref="GOA:P37563" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012094" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015262" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG10130" /db_xref="UniProtKB/Swiss-Prot:P37563" /translation="MKSVKDFLNKHNLTLKGATIIVGVSGGPDSMALLHALHTLCGRS ANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQLVCETAQINVTAYAQEKGLNKQAAAR DCRYQFFEEIMSKHQADYLALAHHGDDQVETMLMKLAKGTLGTGLAGMQPVRRFGTGR IIRPFLTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLPFLKQESPDVHKR FQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQLLALPMPLQRRGVQLIL NYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKN VPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFITSEKKVRFPLTIRTRKA GDRIKLKGMNGSKKVKDIFIDKKLPLQERDNWPIVTDASGEIIWIPGLKKSIFEDLVI PNSDRIVLQYRQHEKCRGQAKS*" /label="tilS CDS" gene 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /label="tilS gene" promotor_-35 75315..75322 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 75337..75356 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 75340 /Source="Nicolas_upshifts" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" downshifts complement(75933) /Source="Nicolas_upshifts" /id="D33" /incds=0 /nref=2 /ntot=142 /MaxReadThrough="2.51342" /MaxDrop="2.96272" /score="12.3455896" /energy="-9.1" /TU="NA" /idTUdmin="U68" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /EC_number="2.4.2.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3110131, 6408059, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 6408059, 24001521; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hypoxanthine-guanine phosphoribosyltransferase" /protein_id="NP_387949.1" /db_xref="EnsemblGenomes-Gn:BSU00680" /db_xref="EnsemblGenomes-Tr:CAB11844" /db_xref="GOA:P37472" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10131" /db_xref="UniProtKB/Swiss-Prot:P37472" /translation="MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKG ALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDII DSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDY AERYRNLPYIGVLKPAVYES*" /label="hprT CDS" gene 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /label="hprT gene" upshifts complement(76340) /Source="Nicolas_upshifts" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(76342..76346) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(76364..76367) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 76478..76574 /Source="Nicolas_S_feature" /locus_tag="new_76887_76983" /HighExp="Diami, H2O2, dia5, G135, dia15, G150, Paraq, C90, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.999, 1, 0.842" /TUlongSig="SigB, SigA" /TUlongPSig="1, 0.99" /label="S38" CDS 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /EC_number="3.4.24.-" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent cytoplasmic membrane protease" /protein_id="NP_387950.1" /db_xref="EnsemblGenomes-Gn:BSU00690" /db_xref="EnsemblGenomes-Tr:CAB11845" /db_xref="GOA:P37476" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="SubtiList:BG10132" /db_xref="UniProtKB/Swiss-Prot:P37476" /translation="MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNL DDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEP AQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKF KDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVI GREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDAR DIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ AGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIAR RMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYE RAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNI LTKTEEKKDDTKE*" /label="ftsH CDS" gene 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /label="ftsH gene" downshifts 78486 /Source="Nicolas_upshifts" /id="D34" /incds=0 /nref=187 /ntot=269 /MaxReadThrough="5.00908" /MaxDrop="8.91482" /score="38.4132386" /energy="-12.9" /TU="U66,U67" /idTUdmin="U64" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(78525..78529) /Source="Nicolas_upshift_promotors" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 78531..78616 /Source="Nicolas_S_feature" /locus_tag="new_78940_79025" /HighExp="H2O2, G180, G135, dia15, Paraq, G150, Oxctl, Diami, Cold, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S39" upshifts complement(78533) /Source="Nicolas_upshifts" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 78593..78600 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 78614..78633 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" S_feature 78618..78682 /Source="Nicolas_S_feature" /locus_tag="new_79027_79091" /HighExp="dia5, H2O2, dia15, Paraq, Diami, G180, LBGexp, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S40" upshifts 78618 /Source="Nicolas_upshifts" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15795230, 16905099, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15795230, 16905099, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase type III" /protein_id="NP_387951.2" /db_xref="EnsemblGenomes-Gn:BSU00700" /db_xref="EnsemblGenomes-Tr:CAB11846" /db_xref="GOA:P37564" /db_xref="InterPro:IPR004619" /db_xref="SubtiList:BG10133" /db_xref="UniProtKB/Swiss-Prot:P37564" /translation="MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILR SLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDN PKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVI ATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV*" /label="coaX CDS" gene 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /label="coaX gene" CDS 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11323724, 15023991; Product type f: factor" /codon_start=1 /transl_table=11 /product="disulfide bond chaperone (heat shock protein HSP33)" /protein_id="NP_387952.1" /db_xref="EnsemblGenomes-Gn:BSU00710" /db_xref="EnsemblGenomes-Tr:CAB11847" /db_xref="GOA:P37565" /db_xref="InterPro:IPR000397" /db_xref="InterPro:IPR016153" /db_xref="InterPro:IPR016154" /db_xref="PDB:1VZY" /db_xref="SubtiList:BG10134" /db_xref="UniProtKB/Swiss-Prot:P37565" /translation="MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGR TMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQG KLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVG VLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEV LGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYL FTKEELEGLRDQTTR*" /label="hslO CDS" gene 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /label="hslO gene" CDS 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 15856219; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein chaperone accessory lipoproteinfactor" /protein_id="NP_387953.1" /db_xref="EnsemblGenomes-Gn:BSU00720" /db_xref="EnsemblGenomes-Tr:CAB11848" /db_xref="GOA:P37566" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR027304" /db_xref="SubtiList:BG10135" /db_xref="UniProtKB/Swiss-Prot:P37566" /translation="MKSRTIWTIILGALLVCCIAVAYTLTKSQAGASSSGESIATIGG KSVTREEWLKEMEDQYGKSTLEDMINVRVVEQLAKKNKLKISKSEVDREFLLIKAVNN SFYEDEHTTEKEWKDQIRYNILLEDLLTRDIDISNKELESFYNKNKELYQFDDSYRIR HIVVKDEEEAREVLKELKGGSSFEAVAAERSTDRYTSPYGGDLGFVTEASDNIPSAYI EEAKTLKEDEWSQEPIKVSNGYAIIQLKEKLKARTFSFDEVKDQIRRQIAMDQLGDKA TVKTLWKEADVSWFYGEKSTK*" /label="yacD CDS" gene 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /label="yacD gene" promotor_-35 81016..81021 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 81038..81056 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 81039 /Source="Nicolas_upshifts" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 81285..81292 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 81307..81326 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 81314 /Source="Nicolas_upshifts" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /EC_number="2.5.1.47" /EC_number="4.4.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 15760717, 16267287, 16513748, 17056751, 18974048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15760717, 16267287, 16513748, 17056751, 18974048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cysteine synthase" /protein_id="NP_387954.1" /db_xref="EnsemblGenomes-Gn:BSU00730" /db_xref="EnsemblGenomes-Tr:CAB11849" /db_xref="GOA:P37887" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10136" /db_xref="UniProtKB/Swiss-Prot:P37887" /translation="MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSV KDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSME RRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGK EIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGP HKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAAL QVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD*" /label="cysK CDS" gene 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /label="cysK gene" downshifts 82281 /Source="Nicolas_upshifts" /id="D35" /incds=0 /nref=156 /ntot=259 /MaxReadThrough="5.90023" /MaxDrop="5.38596" /score="41.7897705" /energy="-11.4" /TU="U72" /idTUdmin="U70" /TUdmin=10 /isTUend="TRUE" /label="downshifts" promotor_-35 82335..82343 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 82357..82365 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 82359 /Source="Nicolas_upshifts" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 82387..82390 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 82405..82424 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 82415 /Source="Nicolas_upshifts" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /EC_number="2.6.1.85" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 9084182, 16605270, 17114263, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)" /protein_id="NP_387955.1" /db_xref="EnsemblGenomes-Gn:BSU00740" /db_xref="EnsemblGenomes-Tr:CAB11850" /db_xref="GOA:P28820" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10137" /db_xref="UniProtKB/Swiss-Prot:P28820" /translation="MAQRRPAGKKIPFQKDSFLQQFEKLAQSRKHHVLLESARGGRYS IAGLDPIATVKGKDGITTIKHGDEMLFKEGDPLRAFHSWFKTLETETNHEFPDFQGGA IGFLSYDYARYIENFKMLSLDDLETPDIYFLVFDDIAVYDHQEESLWLITHVNGSDQE TADVKLSELEQMWLTELPAVTSREMKPETAGSFAAPFTEDGFSQAVEKIKQYIASGDV FQVNLSIRQSQSLSVHPYQIYKTLREVNPSPYMAYLETPDFQIICGSPELLVSKKGKL LETRPIAGTRSRGKTNEEDEALANELIHNEKERAEHVMLVDLERNDLGRVSRYGSVRV NEFMAIEKYSHVMHIVSNVQGELQDGYDAVDIIHAVFPGGTITGAPKVRTMEIIEELE PTRRGLYTGSIGWFGYNHDLQFNIVIRTIYATGGQAFMQSGAGVVIDSVPKHEYKESF KKAFAMQRALELSEEETKIR*" /label="pabB CDS" gene 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /label="pabB gene" promotor_-35 83257..83259 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 83277..83295 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 83283 /Source="Nicolas_upshifts" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 83624..83631 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 83644..83663 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 83657 /Source="Nicolas_upshifts" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /EC_number="2.6.1.85" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098056, 16605270, 17114263, 24847778; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase; anthranilatesynthase (subunit II)" /protein_id="NP_387956.1" /db_xref="EnsemblGenomes-Gn:BSU00750" /db_xref="EnsemblGenomes-Tr:CAB11851" /db_xref="GOA:P28819" /db_xref="InterPro:IPR006221" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10138" /db_xref="UniProtKB/Swiss-Prot:P28819" /translation="MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSP DFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHG KTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDL PIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA*" /label="pabA CDS" gene 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /label="pabA gene" CDS 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /EC_number="4.1.3.38" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10876155, 1644759, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate pyruvate-lyase" /protein_id="NP_387957.1" /db_xref="EnsemblGenomes-Gn:BSU00760" /db_xref="EnsemblGenomes-Tr:CAB11852" /db_xref="GOA:P28821" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR017824" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10139" /db_xref="UniProtKB/Swiss-Prot:P28821" /translation="MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLD WHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFV AQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREI GNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDI GLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKE IKNMIHEKGGRAWRSTQ*" /label="pabC CDS" gene 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /label="pabC gene" CDS 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /EC_number="2.5.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 11007651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydropteroate synthase" /protein_id="NP_387958.1" /db_xref="EnsemblGenomes-Gn:BSU00770" /db_xref="EnsemblGenomes-Tr:CAB11853" /db_xref="GOA:P28822" /db_xref="InterPro:IPR000489" /db_xref="InterPro:IPR006390" /db_xref="InterPro:IPR011005" /db_xref="SubtiList:BG10140" /db_xref="UniProtKB/Swiss-Prot:P28822" /translation="MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKY DSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVP ISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYND LLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPV LLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM LNKGGVHHG*" /label="folP CDS" gene 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /label="folP gene" CDS 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /EC_number="4.1.2.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16188473, 17176045, 17388809; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroneopterin aldolase" /protein_id="NP_387959.1" /db_xref="EnsemblGenomes-Gn:BSU00780" /db_xref="EnsemblGenomes-Tr:CAB11854" /db_xref="GOA:P28823" /db_xref="InterPro:IPR006156" /db_xref="InterPro:IPR006157" /db_xref="SubtiList:BG10141" /db_xref="UniProtKB/Swiss-Prot:P28823" /translation="MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQT DDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDP PIPGHYKSVAIEITRKKS*" /label="folB CDS" gene 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /label="folB gene" CDS 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /EC_number="2.7.6.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17029412; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase" /protein_id="NP_387960.1" /db_xref="EnsemblGenomes-Gn:BSU00790" /db_xref="EnsemblGenomes-Tr:CAB11855" /db_xref="GOA:P29252" /db_xref="InterPro:IPR000550" /db_xref="InterPro:IPR035907" /db_xref="SubtiList:BG10142" /db_xref="UniProtKB/Swiss-Prot:P29252" /translation="MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYET DPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLF NRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVD EFVHSES*" /label="folK CDS" gene 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /label="folK gene" CDS 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_387961.1" /db_xref="EnsemblGenomes-Gn:BSU00800" /db_xref="EnsemblGenomes-Tr:CAB11856" /db_xref="GOA:O31417" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG12701" /db_xref="UniProtKB/Swiss-Prot:O31417" /translation="MEAEIWGRRIRAFRKLKGYTQEGFAKALGISVSILGEIERGNRL PSAAIIQDAADVLNISADELAPPEK*" /label="yazB CDS" gene 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /label="yazB gene" CDS 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 15698474, 26112661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase B" /protein_id="NP_387962.1" /db_xref="EnsemblGenomes-Gn:BSU00810" /db_xref="EnsemblGenomes-Tr:CAB11857" /db_xref="GOA:P37567" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR004652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG10143" /db_xref="UniProtKB/Swiss-Prot:P37567" /translation="MFKIGDIQLKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVS DKAILYNNARTMGMLYIDEREKPLSLQIFGGKKETLVEAAKFVDQNTTADIIDINMGC PVPKITKCDAGAKWLLDPDKIYEMVSAVVDAVNKPVTVKMRMGWDEDHIFAVKNAQAV ERAGGKAVALHGRTRVQMYEGTANWDIIKEVKQSVSIPVIGNGDVKTPQDAKRMLDET GVDGVMIGRAALGNPWMIYRTVQYLETGKLKEEPQVREKMAVCKLHLDRLIDLKGENV AVREMRKHAAWYLKGVKGNANVRNEINHCETREEFVQLLDAFTVEVEAKELQNAKVG* " /label="dusB CDS" gene 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /label="dusB gene" S_feature complement(87641..89157) /Source="Nicolas_S_feature" /locus_tag="new_88050_89566_c" /HighExp="LoTm, C30, S6, S8, S5, S7, S3, S4, C90, G135" /AntisenseName="dusB" /AntisenseCor="-0.60218706634778196" /AntisenseRegPval="-27.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S41" S_feature 88227..88317 /Source="Nicolas_S_feature" /locus_tag="new_88636_88726" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, Diami, C30, LBGexp, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="SigA, SigI, SigA, SigEF, SigA, SigA, SigA" /TUlongPSig="0.621, 0.787, 1, 0.995, 1, 0.999, 1" /label="S42" CDS 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /EC_number="6.1.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14623972, 20649968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14623972, 20649968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lysyl-tRNA synthetase" /protein_id="NP_387963.1" /db_xref="EnsemblGenomes-Gn:BSU00820" /db_xref="EnsemblGenomes-Tr:CAB11858" /db_xref="GOA:P37477" /db_xref="InterPro:IPR002313" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018149" /db_xref="InterPro:IPR034762" /db_xref="SubtiList:BG10144" /db_xref="UniProtKB/Swiss-Prot:P37477" /translation="MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQ EVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVG DDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVE QRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARP FITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIEL YEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATG VDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEI SPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAH LMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR*" /label="lysS CDS" gene 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /label="lysS gene" promotor_-10 complement(89141..89159) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(89157) /Source="Nicolas_upshifts" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(89175..89180) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 89798 /Source="Nicolas_upshifts" /id="D36" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="4.49559" /MaxDrop="4.89484" /score="4.33485487" /energy="-18.1" /TU="U76" /idTUdmin="U74" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 89893..89900 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 89909..90126 /Source="Nicolas_S_feature" /locus_tag="new_90318_90535" /HighExp="LBGstat, H2O2, Oxctl, Diami, dia15, Paraq, MG 25, Heat, MG 15, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 0.998, 1, 1, 0.999, 1" /label="S43" upshifts 89909 /Source="Nicolas_upshifts" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 89914..89933 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(89959) /Source="Nicolas_upshifts" /id="D37" /incds=0 /nref=3 /ntot=51 /MaxReadThrough="3.16217" /MaxDrop="5.0092" /score="18.6635354" /energy="-16.9" /TU="NA" /idTUdmin="U77" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" rRNA 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-16S rRNA" gene 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /label="rrnJ-16S gene" rRNA 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-23S rRNA" gene 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /label="rrnJ-23S gene" rRNA 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-5S rRNA" gene 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /label="rrnJ-5S gene" tRNA 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Val tRNA" gene 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /label="trnJ-Val gene" tRNA 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Thr tRNA" gene 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /label="trnJ-Thr gene" tRNA 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Lys tRNA" gene 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /label="trnJ-Lys gene" tRNA 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu1 tRNA" gene 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /label="trnJ-Leu1 gene" tRNA 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Gly tRNA" gene 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /label="trnJ-Gly gene" tRNA 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu2 tRNA" gene 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /label="trnJ-Leu2 gene" tRNA 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA(ACG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Arg tRNA" gene 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /label="trnJ-Arg gene" tRNA 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Pro(UGG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Pro tRNA" gene 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /label="trnJ-Pro gene" tRNA 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Ala tRNA" gene 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /label="trnJ-Ala gene" rRNA 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-16S rRNA" gene 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /label="rrnW-16S gene" rRNA 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-23S rRNA" gene 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /label="rrnW-23S gene" rRNA 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-5S rRNA" gene 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /label="rrnW-5S gene" S_feature 100803..100880 /Source="Nicolas_S_feature" /locus_tag="new_101212_101289" /HighExp="G135, G180, G150, Cold, Paraq, Oxctl, H2O2, C30, BMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S44" promotor_-35 100850..100853 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100869..100888 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100882 /Source="Nicolas_upshifts" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-35 100916..100922 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-35" promotor_-10 100936..100955 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-10" upshifts 100947 /Source="Nicolas_upshifts" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="upshifts" promotor_-35 100962..100969 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100983..101002 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100995 /Source="Nicolas_upshifts" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of class III stress genes" /protein_id="NP_387964.1" /db_xref="EnsemblGenomes-Gn:BSU00830" /db_xref="EnsemblGenomes-Tr:CAB11859" /db_xref="GOA:P37568" /db_xref="InterPro:IPR008463" /db_xref="SubtiList:BG10145" /db_xref="UniProtKB/Swiss-Prot:P37568" /translation="MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQIN YVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDI ILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK*" /label="ctsR CDS" gene 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /label="ctsR gene" misc_feature complement(101151..101155) /Source="Nicolas_upshift_promotors" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(101157) /Source="Nicolas_upshifts" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 19189946, 24947607" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 19189946, 24947607; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of protein kinase McsB" /protein_id="NP_387965.1" /db_xref="EnsemblGenomes-Gn:BSU00840" /db_xref="EnsemblGenomes-Tr:CAB11860" /db_xref="GOA:P37569" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR025542" /db_xref="InterPro:IPR029037" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10146" /db_xref="UniProtKB/Swiss-Prot:P37569" /translation="MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISA NQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSEC YKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFEN AAHVRDQIRLLEQSLKSTDSEEEQE*" /label="mcsA CDS" gene 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /label="mcsA gene" CDS 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /EC_number="2.7.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 17380125, 19189946, 21622759, 25610436, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein arginine kinase" /protein_id="NP_387966.1" /db_xref="EnsemblGenomes-Gn:BSU00850" /db_xref="EnsemblGenomes-Tr:CAB11861" /db_xref="GOA:P37570" /db_xref="InterPro:IPR000749" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR022414" /db_xref="InterPro:IPR022415" /db_xref="InterPro:IPR023660" /db_xref="SubtiList:BG10147" /db_xref="UniProtKB/Swiss-Prot:P37570" /translation="MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTR YSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESP FGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQ RGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVG NIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGV LSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRP NERDIRRAALIRERLHLEMNGKRQEDESI*" /label="mcsB CDS" gene 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /label="mcsB gene" CDS 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354604, 15529410, 16525504, 26735940, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III stress response-related ATPase, AAA+ superfamily" /protein_id="NP_387967.1" /db_xref="EnsemblGenomes-Gn:BSU00860" /db_xref="EnsemblGenomes-Tr:CAB11862" /db_xref="GOA:P37571" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004176" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="InterPro:IPR036628" /db_xref="PDB:2K77" /db_xref="PDB:2Y1Q" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="PDB:5HBN" /db_xref="SubtiList:BG10148" /db_xref="UniProtKB/Swiss-Prot:P37571" /translation="MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEG IAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSY VGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIA EGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIIL FIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRF QPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAI DLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLR EQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHS RVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDE ESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHP DVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNH KDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLS IELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVED GEFVVKTTAKTN*" /label="clpC CDS" gene 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /label="clpC gene" downshifts 105590 /Source="Nicolas_upshifts" /id="D38" /incds=0 /nref=57 /ntot=245 /MaxReadThrough="6.69446" /MaxDrop="4.4703" /score="-8.32149463" /energy="-11.7" /TU="U80,U81" /idTUdmin="U79" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /EC_number="2.1.1.63" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931349, 11810266, 15317759, 25616256; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair protein; 6-O-methylguanine-DNA methyltransferase" /protein_id="NP_387968.1" /db_xref="EnsemblGenomes-Gn:BSU00870" /db_xref="EnsemblGenomes-Tr:CAB11863" /db_xref="GOA:P37572" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004504" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10149" /db_xref="UniProtKB/Swiss-Prot:P37572" /translation="MAKTKSKFICQSCGYESPKWMGKCPGCGAWNTMVEEMIKKAPAN RRAAFSHSVQTVQKPSPITSIETSEEPRVKTQLGEFNRVLGGGVVKGSLVLIGGDPGI GKSTLLLQVSAQLSGSSNSVLYISGEESVKQTKLRADRLGINNPSLHVLSETDMEYIS SAIQEMNPSFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTKGIPIFIVGHV TKEGSIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTE VLNPSEIFLEERSAGSAGSSITASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNR VSLLMAVLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAIVISIASSFRDTPPNPADC FIGEVGLTGEVRRVSRIEQRVKEAAKLGFKRMIIPAANLDGWTKPKGIEVIGVANVAE ALRTSLGG*" /label="radA CDS" gene 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /label="radA gene" promotor_-35 106142..106151 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 106164..106179 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 106167 /Source="Nicolas_upshifts" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein" /protein_id="NP_387969.1" /db_xref="EnsemblGenomes-Gn:BSU00880" /db_xref="EnsemblGenomes-Tr:CAB11864" /db_xref="GOA:P37573" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR018906" /db_xref="InterPro:IPR023763" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG10150" /db_xref="UniProtKB/Swiss-Prot:P37573" /translation="MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIV VGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATI SSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAI QTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTE GHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKL LGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEG IGEVRAQKIKKGLKRLQEKHYLDRQL*" /label="disA CDS" gene 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /label="disA gene" S_feature 108150..108264 /Source="Nicolas_S_feature" /locus_tag="new_108559_108673" /HighExp="Etha, Salt, Heat, dia15, Diami, M9-stat, B60, T-0.40H, T-1.10H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.947" /label="S45" CDS 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26999498; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein possibly involved in RNA binding" /protein_id="NP_387970.1" /db_xref="EnsemblGenomes-Gn:BSU00890" /db_xref="EnsemblGenomes-Tr:CAB11865" /db_xref="GOA:Q06754" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG10151" /db_xref="UniProtKB/Swiss-Prot:Q06754" /translation="MLKRIVQAFFIIFGGVVGIFLIPELFVLLNIQDIPLITNAYTSA AIGAIIFFLISIWGTEYVVNWVKWIEDSLLKAPVPDLLFGSLGLVFGLIIAYLIVNVI PLDNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGTADEEH EVQDKKLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRG RRGLDILNRIQKELDIEVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCE LQKVAVLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNY IGKHIDVLVTSVLQTAAGRMIFAKPKLLEKAL*" /label="yacL CDS" gene 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /label="yacL gene" downshifts complement(109187) /Source="Nicolas_upshifts" /id="D39" /incds=1 /nref=1 /ntot=103 /MaxReadThrough="0.39171" /MaxDrop="2.87304" /score="-9.71423487" /energy="-11.8" /TU="NA" /idTUdmin="U82" /TUdmin="-8228" /isTUend="FALSE" /label="downshifts" CDS 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /EC_number="2.7.7.60" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, nonmevalonate isoprenoid pathway" /protein_id="NP_387971.1" /db_xref="EnsemblGenomes-Gn:BSU00900" /db_xref="EnsemblGenomes-Tr:CAB11866" /db_xref="GOA:Q06755" /db_xref="InterPro:IPR001228" /db_xref="InterPro:IPR018294" /db_xref="InterPro:IPR029044" /db_xref="InterPro:IPR034683" /db_xref="PDB:5DDT" /db_xref="PDB:5DDV" /db_xref="PDB:5HS2" /db_xref="SubtiList:BG10152" /db_xref="UniProtKB/Swiss-Prot:Q06755" /translation="MSYDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHR QCDKIILVINEQEREHFQQLLSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLV HDGARPFIKHEQIDELIAEAEQTGAAILAVPVKDTIKRVQDLQVSETIERSSLWAVQT PQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTS AEAIMESESGNKHV*" /label="ispD CDS" gene 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /label="ispD gene" CDS 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /EC_number="4.6.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9622350, 11997478, 12270818, 12682299, 17458547, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 11997478, 12270818, 12682299, 17458547, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase" /protein_id="NP_387972.1" /db_xref="EnsemblGenomes-Gn:BSU00910" /db_xref="EnsemblGenomes-Tr:CAB11867" /db_xref="GOA:Q06756" /db_xref="InterPro:IPR003526" /db_xref="InterPro:IPR020555" /db_xref="InterPro:IPR036571" /db_xref="PDB:5IWX" /db_xref="PDB:5IWY" /db_xref="SubtiList:BG10153" /db_xref="UniProtKB/Swiss-Prot:Q06756" /translation="MFRIGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHT VADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQ KPKMLPYIEDMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKG*" /label="ispF CDS" gene 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /label="ispF gene" promotor_-35 110551..110558 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 110572..110591 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 110585 /Source="Nicolas_upshifts" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /EC_number="6.1.1.24" /EC_number="6.1.1.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA synthetase" /protein_id="NP_387973.1" /db_xref="EnsemblGenomes-Gn:BSU00920" /db_xref="EnsemblGenomes-Tr:CAB11868" /db_xref="GOA:P22250" /db_xref="InterPro:IPR000924" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR004527" /db_xref="InterPro:IPR008925" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020058" /db_xref="InterPro:IPR020061" /db_xref="InterPro:IPR020751" /db_xref="InterPro:IPR020752" /db_xref="InterPro:IPR033910" /db_xref="SubtiList:BG10154" /db_xref="UniProtKB/Swiss-Prot:P22250" /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVE DTDKKRNIEGGEQSQLNYLKWLGIDWDESVDVGGEYGPYRQSERNDIYKVYYEELLEK GLAYKCYCTEEELEKEREEQIARGEMPRYSGKHRDLTQEEQEKFIAEGRKPSIRFRVP EGKVIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDH ISNTPKQIMIYQAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEA LFNFIGLLGWSPVGEEELFTKEQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKKLDL DQVVELTLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFTDEI EYNQEAKAVLEEEQVPEVLSTFAAKLEELEEFTPDNIKASIKAVQKETGHKGKKLFMP IRVAVTGQTHGPELPQSIELIGKETAIQRLKNI*" /label="gltX CDS" gene 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /label="gltX gene" promotor_-35 111567..111576 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-35" promotor_-10 111590..111609 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-10" upshifts 111590 /Source="Nicolas_upshifts" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="upshifts" S_feature 112090..112390 /Source="Nicolas_S_feature" /locus_tag="new_112499_112799" /HighExp="S6, S8, S7, Diami, C90, LBGexp, G135, H2O2, dia5, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17844199999999999" /TUshortSig="SigK, SigA, SigWXY" /TUshortPSig="1, 0.999, 1" /TUlongSig="SigA, SigB, SigA" /TUlongPSig="1, 1, 0.947" /label="S46" CDS 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /EC_number="2.3.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7510287, 10737181, 10939241, 17056751, 18974048, 25731080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7510287, 10737181, 10939241, 17056751, 18974048, 25731080; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine O-acetyltransferase" /protein_id="NP_387974.1" /db_xref="EnsemblGenomes-Gn:BSU00930" /db_xref="EnsemblGenomes-Tr:CAB11869" /db_xref="GOA:Q06750" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005881" /db_xref="InterPro:IPR010493" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="SubtiList:BG10155" /db_xref="UniProtKB/Swiss-Prot:Q06750" /translation="MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHA LYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVF QGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFST VVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK* " /label="cysE CDS" gene 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /label="cysE gene" CDS 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /EC_number="6.1.1.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10024179, 10546897, 10931887, 12682299, 29079736" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024179, 10546897, 10931887, 12682299, 29079736; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual cysteinyl-tRNA synthetase; cysteine persulfide synthase" /protein_id="NP_387975.1" /db_xref="EnsemblGenomes-Gn:BSU00940" /db_xref="EnsemblGenomes-Tr:CAB11870" /db_xref="GOA:Q06752" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015273" /db_xref="InterPro:IPR015803" /db_xref="InterPro:IPR024909" /db_xref="InterPro:IPR032678" /db_xref="SubtiList:BG10156" /db_xref="UniProtKB/Swiss-Prot:Q06752" /translation="MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARP AIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVG ALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSI DELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLG DQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVL VHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSST NLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVI TAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMN IILEDTAQGTRWKRGE*" /label="cysS CDS" gene 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /label="cysS gene" CDS 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 25634891, 27924926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 25634891, 27924926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease for 23S RNA maturation, mini-RNase III" /protein_id="NP_387976.1" /db_xref="EnsemblGenomes-Gn:BSU00950" /db_xref="EnsemblGenomes-Tr:CAB11871" /db_xref="GOA:O31418" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR008226" /db_xref="InterPro:IPR036389" /db_xref="PDB:4OUN" /db_xref="SubtiList:BG12702" /db_xref="UniProtKB/Swiss-Prot:O31418" /translation="MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPND LHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYS TAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT*" /label="mrnC CDS" gene 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /label="mrnC gene" CDS 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /EC_number="2.1.1.185" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11698387, 12377117, 16014871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (Gm2251)-methyltransferase" /protein_id="NP_387977.1" /db_xref="EnsemblGenomes-Gn:BSU00960" /db_xref="EnsemblGenomes-Tr:CAB11872" /db_xref="GOA:Q06753" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004441" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG10157" /db_xref="UniProtKB/Swiss-Prot:Q06753" /translation="MSQQHDYVIGKNAVIETLKSDRKLYKLWMAENTVKGQAQQVIEL AKKQGITIQYVPRKKLDQMVTGQHQGVVAQVAAYEYAELDDLYKAAEEKNEQPFFLIL DELEDPHNLGSIMRTADAVGAHGIVIPKRRAVGLTTTVAKASTGAIEHIPVARVTNLA RTLEEMKERGIWVVGTDASAREDFRNMDGNMPLALVIGSEGKGMGRLVKEKCDFLIKL PMAGKVTSLNASVAAGLLMYEVYRKRNPVGE*" /label="rlmB CDS" gene 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /label="rlmB gene" CDS 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17114934, 23355615, 28363943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17114934, 23355615, 28363943; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-dependent mRNA endonuclease" /protein_id="NP_387978.1" /db_xref="EnsemblGenomes-Gn:BSU00970" /db_xref="EnsemblGenomes-Tr:CAB11873" /db_xref="InterPro:IPR010298" /db_xref="PDB:5MQ8" /db_xref="PDB:5MQ9" /db_xref="SubtiList:BG10158" /db_xref="UniProtKB/Swiss-Prot:P37574" /translation="MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYT GNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVAT SDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKT FEKWRRGDLD*" /label="raeA CDS" gene 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /label="raeA gene" promotor_-35 116127..116134 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 116149..116168 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 116151 /Source="Nicolas_upshifts" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169614, 16339734, 25288929, 26712348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169614, 16339734, 25288929, 26712348; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-30 factor (sigma(H))" /protein_id="NP_387979.1" /db_xref="EnsemblGenomes-Gn:BSU00980" /db_xref="EnsemblGenomes-Tr:CAB11874" /db_xref="GOA:P17869" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014218" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR016371" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10159" /db_xref="UniProtKB/Swiss-Prot:P17869" /translation="MNLQNNKGKFNKEQFCQLEDEQVIEKVHVGDSDALDYLITKYRN FVRAKARSYFLIGADREDIVQEGMIGLYKSIRDFKEDKLTSFKAFAELCITRQIITAI KTATRQKHIPLNSYASLDKPIFDEESDRTLLDVISGAKTLNPEEMIINQEEFDDIEMK MGELLSDLERKVLVLYLDGRSYQEISDELNRHVKSIDNALQRVKRKLEKYLEIREISL *" /label="sigH CDS" gene 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /label="sigH gene" downshifts complement(116645) /Source="Nicolas_upshifts" /id="D40" /incds=1 /nref=1 /ntot=107 /MaxReadThrough="2.38622" /MaxDrop="2.50464" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=836 /isTUend="FALSE" /label="downshifts" S_feature 116848..116939 /Source="Nicolas_S_feature" /locus_tag="new_117257_117348" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, S1, S2, T5.0H, HiOs, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S47" CDS 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586115, 19648245, 23002217, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586115, 19648245, 23002217, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_387980.1" /db_xref="EnsemblGenomes-Gn:BSU00990" /db_xref="EnsemblGenomes-Tr:CAB11875" /db_xref="GOA:Q06798" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="SubtiList:BG10160" /db_xref="UniProtKB/Swiss-Prot:Q06798" /translation="MRKKITLACKTCGNRNYTTMKSSASAAERLEVKKYCSTCNSHTA HLETK*" /label="rpmGB CDS" gene 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /label="rpmGB gene" CDS 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11976315, 12682299, 16242710, 22304380, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11976315, 12682299, 16242710, 22304380, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_387981.1" /db_xref="EnsemblGenomes-Gn:BSU01000" /db_xref="EnsemblGenomes-Tr:CAB11876" /db_xref="GOA:Q06799" /db_xref="InterPro:IPR001901" /db_xref="InterPro:IPR005807" /db_xref="InterPro:IPR022943" /db_xref="SubtiList:BG10161" /db_xref="UniProtKB/Swiss-Prot:Q06799" /translation="MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFA LLDTGISQLIRLIVE*" /label="secE CDS" gene 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /label="secE gene" S_feature 117303..117480 /Source="Nicolas_S_feature" /locus_tag="new_117712_117889" /HighExp="Cold, G180, G150, H2O2, LoTm, Oxctl, G135, Paraq, LBGexp, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S48" downshifts complement(117474) /Source="Nicolas_upshifts" /id="D41" /incds=0 /nref=37 /ntot=175 /MaxReadThrough="1.57397" /MaxDrop="4.03552" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11101662, 16014871, 16707701, 18852477, 26742846, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101662, 16014871, 16707701, 18852477, 26742846, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase elongation pause factor" /protein_id="NP_387982.1" /db_xref="EnsemblGenomes-Gn:BSU01010" /db_xref="EnsemblGenomes-Tr:CAB11877" /db_xref="GOA:Q06795" /db_xref="InterPro:IPR001062" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR006645" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015869" /db_xref="InterPro:IPR036735" /db_xref="SubtiList:BG10162" /db_xref="UniProtKB/Swiss-Prot:Q06795" /translation="MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEE ETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLL PGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNM FGRETPVELEFTQIDKL*" /label="nusG CDS" gene 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /label="nusG gene" upshifts complement(117569) /Source="Nicolas_upshifts" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(117572..117576) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(117591..117596) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 118025..118032 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 118043..118181 /Source="Nicolas_S_feature" /locus_tag="new_118452_118590" /HighExp="T-1.40H, ferm, T-3.40H, T-5.40H, BI, B36, LoTm, SMM, T-2.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S49" upshifts 118043 /Source="Nicolas_upshifts" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 118046..118065 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11244072, 19653700, 20441189" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244072, 19653700, 20441189; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 (BL11)" /protein_id="NP_387983.2" /db_xref="EnsemblGenomes-Gn:BSU01020" /db_xref="EnsemblGenomes-Tr:CAB11878" /db_xref="GOA:Q06796" /db_xref="InterPro:IPR000911" /db_xref="InterPro:IPR006519" /db_xref="InterPro:IPR020783" /db_xref="InterPro:IPR020784" /db_xref="InterPro:IPR020785" /db_xref="InterPro:IPR036769" /db_xref="InterPro:IPR036796" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG10163" /db_xref="UniProtKB/Swiss-Prot:Q06796" /translation="MAKKVVKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNA RTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKR DKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIED*" /label="rplK CDS" gene 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /label="rplK gene" S_feature 118608..118701 /Source="Nicolas_S_feature" /locus_tag="new_119017_119110" /HighExp="HPh, LPh, Lbexp, G180, LBGexp, G150, Heat, Cold, Fru, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S50" CDS 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16352840, 17981968, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L1 (BL1)" /protein_id="NP_387984.2" /db_xref="EnsemblGenomes-Gn:BSU01030" /db_xref="EnsemblGenomes-Tr:CAB11879" /db_xref="GOA:Q06797" /db_xref="InterPro:IPR002143" /db_xref="InterPro:IPR005878" /db_xref="InterPro:IPR016095" /db_xref="InterPro:IPR023673" /db_xref="InterPro:IPR023674" /db_xref="InterPro:IPR028364" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="SubtiList:BG10164" /db_xref="UniProtKB/Swiss-Prot:Q06797" /translation="MAKKGKKYVEAAKLVDRSKAYDVSEAVALVKKTNTAKFDATVEV AFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADFVGDTDYIN KIQQGWFDFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGK VEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTM GPGVKVDSSTFNVK*" /label="rplA CDS" gene 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /label="rplA gene" downshifts complement(119374) /Source="Nicolas_upshifts" /id="D42" /incds=0 /nref=3 /ntot=95 /MaxReadThrough="3.54108" /MaxDrop="3.36566" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U89" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /product="L10_leader" /experiment="publication(s) with functional evidences, PMID:26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26101249; Product type n: RNA" /label="ldlJ RNA" gene 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /label="ldlJ gene" upshifts complement(119462) /Source="Nicolas_upshifts" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(119465..119469) /Source="Nicolas_upshift_promotors" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 119518 /Source="Nicolas_upshifts" /id="D43" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="9.14839" /MaxDrop="2.9211" /score="20.0562348" /energy="-13.2" /TU="U88" /idTUdmin="U84" /TUdmin=1497 /isTUend="FALSE" /label="downshifts" CDS 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9810686, 11341315, 12682299, 18247578, 26101249, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9810686, 11341315, 12682299, 18247578, 26101249, 22720735; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L10 (BL5)" /protein_id="NP_387985.2" /db_xref="EnsemblGenomes-Gn:BSU01040" /db_xref="EnsemblGenomes-Tr:CAB11880" /db_xref="GOA:P42923" /db_xref="InterPro:IPR001790" /db_xref="InterPro:IPR002363" /db_xref="InterPro:IPR022973" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11220" /db_xref="UniProtKB/Swiss-Prot:P42923" /translation="MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQ LREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKN HEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQ KEEQGA*" /label="rplJ CDS" gene 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /label="rplJ gene" CDS 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 6771249, 8755892, 26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 6771249, 8755892, 26101249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L12 (BL9)" /protein_id="NP_387986.1" /db_xref="EnsemblGenomes-Gn:BSU01050" /db_xref="EnsemblGenomes-Tr:CAB11881" /db_xref="GOA:P02394" /db_xref="InterPro:IPR000206" /db_xref="InterPro:IPR008932" /db_xref="InterPro:IPR013823" /db_xref="InterPro:IPR014719" /db_xref="InterPro:IPR036235" /db_xref="SubtiList:BG10726" /db_xref="UniProtKB/Swiss-Prot:P02394" /translation="MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGG AAAGGAAEEQSEFDLILAGAGSQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIA KEEAEELKAKLEEVGASVEVK*" /label="rplL CDS" gene 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /label="rplL gene" downshifts 120485 /Source="Nicolas_upshifts" /id="D44" /incds=1 /nref=5 /ntot=149 /MaxReadThrough="8.89506" /MaxDrop="4.0945" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2464 /isTUend="FALSE" /label="downshifts" downshifts 120558 /Source="Nicolas_upshifts" /id="D45" /incds=0 /nref=25 /ntot=157 /MaxReadThrough="7.44654" /MaxDrop="4.0033" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2537 /isTUend="FALSE" /label="downshifts" CDS 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /EC_number="2.1.1.174" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17010380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2G1835 methyltransferase" /protein_id="NP_387987.1" /db_xref="EnsemblGenomes-Gn:BSU01060" /db_xref="EnsemblGenomes-Tr:CAB11882" /db_xref="GOA:P37872" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10727" /db_xref="UniProtKB/Swiss-Prot:P37872" /translation="MSEHYYSEKPSVKSNKQTWSFRLRNKDFTFTSDSGVFSKKEVDF GSRLLIDSFEEPEVEGGILDVGCGYGPIGLSLASDFKDRTIHMIDVNERAVELSNENA EQNGITNVKIYQSDLFSNVDSAQTFASILTNPPIRAGKKVVHAIFEKSAEHLKASGEL WIVIQKKQGAPSAIEKLEELFDEVSVVQKKKGYYIIKAKKV*" /label="rlmG CDS" gene 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /label="rlmG gene" promotor_-35 121259..121263 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 121277..121509 /Source="Nicolas_S_feature" /locus_tag="new_121686_121918" /HighExp="G180, G150, H2O2, G135, Cold, T-5.40H, LoTm, T-3.40H, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S51" upshifts 121277 /Source="Nicolas_upshifts" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 121279..121298 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10049799, 10744988, 12455702, 12682299, 15060052, 28163698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10049799, 10744988, 12455702, 12682299, 15060052, 28163698; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta subunit)" /protein_id="NP_387988.2" /db_xref="EnsemblGenomes-Gn:BSU01070" /db_xref="EnsemblGenomes-Tr:CAB11883" /db_xref="GOA:P37870" /db_xref="InterPro:IPR007120" /db_xref="InterPro:IPR007121" /db_xref="InterPro:IPR007641" /db_xref="InterPro:IPR007642" /db_xref="InterPro:IPR007644" /db_xref="InterPro:IPR007645" /db_xref="InterPro:IPR010243" /db_xref="InterPro:IPR015712" /db_xref="InterPro:IPR019462" /db_xref="PDB:2LY7" /db_xref="SubtiList:BG10728" /db_xref="UniProtKB/Swiss-Prot:P37870" /translation="MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEG LREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKE TGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTA TVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEILDLIGENEYLR NTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLANVGRYKIN KKLHIKNRLFNQRLAETLVDPETGEILAEKGQILDRRTLDKVLPYLENGIGFRKLYPN GGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIEEEIKNITPADIISSISYFFNLL HGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLIN IRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHY SHYGRMCPIETPEGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTA DEEDNYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVSAATA CIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDSGAAVICKHPGIV ERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVVKGE ILADGPSMELGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESE ARDTKLGPEEITRDIPNVGEDALRNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTA EERLLHAIFGEKAREVRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIV QKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVL ELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRV SVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGA AYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILS GDEEEIEMRDLEDEEDAKQADGLALSGDEEPEETASADVERDVVTKE*" /label="rpoB CDS" gene 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /label="rpoB gene" promotor_-10 complement(123095..123114) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123098) /Source="Nicolas_upshifts" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123128..123137) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(123966..123970) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123971) /Source="Nicolas_upshifts" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123985..123991) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta' subunit)" /protein_id="NP_387989.2" /db_xref="EnsemblGenomes-Gn:BSU01080" /db_xref="EnsemblGenomes-Tr:CAB11884" /db_xref="GOA:P37871" /db_xref="InterPro:IPR000722" /db_xref="InterPro:IPR006592" /db_xref="InterPro:IPR007066" /db_xref="InterPro:IPR007080" /db_xref="InterPro:IPR007081" /db_xref="InterPro:IPR007083" /db_xref="InterPro:IPR012754" /db_xref="SubtiList:BG10729" /db_xref="UniProtKB/Swiss-Prot:P37871" /translation="MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKD GLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVS HIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLD KYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRN SGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGA PSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGK RVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIER VQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADF DGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAG AVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLV FNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKII AEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDN VMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASN FTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSG YLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPE TGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVE VGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATIT EIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSID PKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDV LPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVL TDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE*" /label="rpoC CDS" gene 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /label="rpoC gene" downshifts complement(128217) /Source="Nicolas_upshifts" /id="D46" /incds=1 /nref=1 /ntot=76 /MaxReadThrough="3.40002" /MaxDrop="2.38911" /score="-2.05539956" /energy="-7.5" /TU="U93" /idTUdmin="U93" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" upshifts complement(128371) /Source="Nicolas_upshifts" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(128389..128390) /Source="Nicolas_upshift_promotors" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(128701) /Source="Nicolas_upshifts" /id="D47" /incds=0 /nref=98 /ntot=210 /MaxReadThrough="1.61828" /MaxDrop="4.90549" /score="-2.05539956" /energy="-7.5" /TU="NA" /idTUdmin="U95" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 128753..128874 /Source="Nicolas_S_feature" /locus_tag="new_129162_129283" /HighExp="LoTm, HiOs, S3, SMMPr, Heat, S1, BC, Glu, S4, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S52" promotor_-35 128856..128863 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" upshifts 128876 /Source="Nicolas_upshifts" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 128877..128896 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" misc_feature complement(128894..128898) /Source="Nicolas_upshift_promotors" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(128897) /Source="Nicolas_upshifts" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein; alternative ribosomal protein L7A" /protein_id="NP_387990.1" /db_xref="EnsemblGenomes-Gn:BSU01090" /db_xref="EnsemblGenomes-Tr:CAB11885" /db_xref="GOA:P46350" /db_xref="InterPro:IPR000948" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR023460" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7E" /db_xref="PDB:4LCK" /db_xref="PDB:4TZP" /db_xref="PDB:4TZV" /db_xref="PDB:4TZW" /db_xref="PDB:4TZZ" /db_xref="SubtiList:BG11365" /db_xref="UniProtKB/Swiss-Prot:P46350" /translation="MSYDKVSQAKSIIIGTKQTVKALKRGSVKEVVVAKDADPILTSS VVSLAEDQGISVSMVESMKKLGKACGIEVGAAAVAIIL*" /label="rulS CDS" gene 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /label="rulS gene" S_feature 129180..129292 /Source="Nicolas_S_feature" /locus_tag="new_129589_129701" /HighExp="T-3.40H, M/G, T-1.40H, T-5.40H, Salt, Mal, T-0.40H, G/S, M9-exp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S53" CDS 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11489846, 12682299, 16484214, 18252828, 19383706, 20007320" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489846, 12682299, 16484214, 18252828, 19383706, 20007320; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S12 (BS12)" /protein_id="NP_387991.2" /db_xref="EnsemblGenomes-Gn:BSU01100" /db_xref="EnsemblGenomes-Tr:CAB11886" /db_xref="GOA:P21472" /db_xref="InterPro:IPR005679" /db_xref="InterPro:IPR006032" /db_xref="InterPro:IPR012340" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19009" /db_xref="UniProtKB/Swiss-Prot:P21472" /translation="MPTINQLIRKGRVSKVENSKSPALNKGYNSFKKEHTNVSSPQKR GVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKD LPGVRYHIVRGALDTAGVENRAQGRSKYGTKKPKAK*" /label="rpsL CDS" gene 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /label="rpsL gene" CDS 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 19653700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 19653700; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S7 (BS7)" /protein_id="NP_387992.2" /db_xref="EnsemblGenomes-Gn:BSU01110" /db_xref="EnsemblGenomes-Tr:CAB11887" /db_xref="GOA:P21469" /db_xref="InterPro:IPR000235" /db_xref="InterPro:IPR005717" /db_xref="InterPro:IPR020606" /db_xref="InterPro:IPR023798" /db_xref="InterPro:IPR036823" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19006" /db_xref="UniProtKB/Swiss-Prot:P21469" /translation="MPRKGPVAKRDVLPDPIYNSKLVSRLINKMMIDGKKGKSQTILY KSFDIIKERTGNDAMEVFEQALKNIMPVLEVKARRVGGANYQVPVEVRPERRTTLGLR WLVNYARLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW*" /label="rpsG CDS" gene 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /label="rpsG gene" CDS 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:815236, 815243, 1556067, 4629789, 19366171, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 815236, 815243, 1556067, 4629789, 19366171, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="elongation factor G" /protein_id="NP_387993.2" /db_xref="EnsemblGenomes-Gn:BSU01120" /db_xref="EnsemblGenomes-Tr:CAB11888" /db_xref="GOA:P80868" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004540" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005517" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009022" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035649" /db_xref="PDB:5VH6" /db_xref="SubtiList:BG11939" /db_xref="UniProtKB/Swiss-Prot:P80868" /translation="MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETH EGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGA VAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAH AIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAV CELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLD YLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTL DSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEK DLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIIS GMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHV WIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLF DGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITS RRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVA EEIIKKNKGE*" /label="fusA CDS" gene 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /label="fusA gene" S_feature 132354..132472 /Source="Nicolas_S_feature" /locus_tag="new_132763_132881" /HighExp="T-5.40H, T-4.40H, UNK1, SMM, HiTm, T-3.40H, T-2.40H, SMMPr, MG 90, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S54" CDS 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10774755, 12682299, 7706132, 20133608, 22938038, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10774755, 12682299, 7706132, 20133608, 22938038, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="elongation factor Tu" /protein_id="NP_387994.1" /db_xref="EnsemblGenomes-Gn:BSU01130" /db_xref="EnsemblGenomes-Tr:CAB11889" /db_xref="GOA:P33166" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004160" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004541" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR033720" /db_xref="SubtiList:BG11056" /db_xref="UniProtKB/Swiss-Prot:P33166" /translation="MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGT AMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDG AILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLS EYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVED VFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDN IGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFY FRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVS TITE*" /label="tufA CDS" gene 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /label="tufA gene" downshifts 133658 /Source="Nicolas_upshifts" /id="D48" /incds=0 /nref=258 /ntot=269 /MaxReadThrough="4.84568" /MaxDrop="8.56168" /score="39.3984056" /energy="-12.9" /TU="U88,U90,U94" /idTUdmin="U88" /TUdmin="-1081" /isTUend="FALSE" /label="downshifts" misc_feature complement(133689..133692) /Source="Nicolas_upshift_promotors" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(133693) /Source="Nicolas_upshifts" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 133719..133738 /Source="Nicolas_upshift_promotors" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 133727 /Source="Nicolas_upshifts" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /EC_number="3.4.11.5" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proline iminopeptidase" /protein_id="NP_387995.2" /db_xref="EnsemblGenomes-Gn:BSU01140" /db_xref="EnsemblGenomes-Tr:CAB11890" /db_xref="GOA:P70981" /db_xref="InterPro:IPR002410" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11988" /db_xref="UniProtKB/Swiss-Prot:P70981" /translation="MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGT PQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLA HFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISE SKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNE YGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQ YYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL*" /label="ybaC CDS" gene 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /label="ybaC gene" promotor_-35 134725..134732 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 134746..134765 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 134761..134954 /Source="Nicolas_S_feature" /locus_tag="new_135170_135363" /HighExp="T-1.40H, T-2.40H, T-1.10H, SMM, T-3.40H, T-4.40H, BI, BMM, H2O2, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S55" upshifts 134761 /Source="Nicolas_upshifts" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 27964882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 27964882; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S10 (BS13); transcription antitermination factor" /protein_id="NP_387996.1" /db_xref="EnsemblGenomes-Gn:BSU01150" /db_xref="EnsemblGenomes-Tr:CAB11891" /db_xref="GOA:P21471" /db_xref="InterPro:IPR001848" /db_xref="InterPro:IPR018268" /db_xref="InterPro:IPR027486" /db_xref="InterPro:IPR036838" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19008" /db_xref="UniProtKB/Swiss-Prot:P21471" /translation="MAKQKIRIRLKAYDHRILDQSAEKIVETAKRSGASVSGPIPLPT EKSVYTILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL *" /label="rpsJ CDS" gene 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /label="rpsJ gene" CDS 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 19154332, 23759864" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 19154332, 23759864; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L3 (BL3)" /protein_id="NP_387997.1" /db_xref="EnsemblGenomes-Gn:BSU01160" /db_xref="EnsemblGenomes-Tr:CAB11892" /db_xref="GOA:P42920" /db_xref="InterPro:IPR000597" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR019926" /db_xref="InterPro:IPR019927" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11218" /db_xref="UniProtKB/Swiss-Prot:P42920" /translation="MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAEND GYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIF SAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLL PGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK*" /label="rplC CDS" gene 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /label="rplC gene" CDS 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10898684, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L4" /protein_id="NP_387998.1" /db_xref="EnsemblGenomes-Gn:BSU01170" /db_xref="EnsemblGenomes-Tr:CAB11893" /db_xref="GOA:P42921" /db_xref="InterPro:IPR002136" /db_xref="InterPro:IPR013005" /db_xref="InterPro:IPR023574" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11219" /db_xref="UniProtKB/Swiss-Prot:P42921" /translation="MPKVALYNQNGSTAGDIELNASVFGIEPNESVVFDAILMQRASL RQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYSYKLP KKVRRLAIKSVLSSKVIDNNIIVLEDLTLDTAKTKEMAAILKGLSVEKKALIVTADAN EAVALSARNIPGVTVVEANGINVLDVVNHEKLLITKAAVEKVEEVLA*" /label="rplD CDS" gene 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /label="rplD gene" CDS 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L23" /protein_id="NP_387999.2" /db_xref="EnsemblGenomes-Gn:BSU01180" /db_xref="EnsemblGenomes-Tr:CAB11894" /db_xref="GOA:P42924" /db_xref="InterPro:IPR001014" /db_xref="InterPro:IPR012678" /db_xref="InterPro:IPR013025" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11221" /db_xref="UniProtKB/Swiss-Prot:P42924" /translation="MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVE SIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA*" /label="rplW CDS" gene 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /label="rplW gene" CDS 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23249812, 24637032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23249812, 24637032; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L2 (BL2)" /protein_id="NP_388000.2" /db_xref="EnsemblGenomes-Gn:BSU01190" /db_xref="EnsemblGenomes-Tr:CAB11895" /db_xref="GOA:P42919" /db_xref="InterPro:IPR002171" /db_xref="InterPro:IPR005880" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR014726" /db_xref="InterPro:IPR022666" /db_xref="InterPro:IPR022669" /db_xref="InterPro:IPR022671" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11217" /db_xref="UniProtKB/Swiss-Prot:P42919" /translation="MAIKKYKPTSNGRRGMTTSDFAEITTDKPEKSLLAPLHKKGGRN NQGKLTVRHQGGGHKRQYRVIDFKRDKDGIPGRVATVEYDPNRSANIALINYADGEKR YILAPKGIQVGTEIMSGPEADIKVGNALPLINIPVGTVVHNIELKPGKGGQLVRSAGT SAQVLGKEGKYVLVRLNSGEVRMILSACRASIGQVGNEQHELINIGKAGRSRWKGIRP TVRGSVMNPNDHPHGGGEGRAPIGRKSPMSPWGKPTLGFKTRKKKNKSDKFIVRRRKN K*" /label="rplB CDS" gene 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /label="rplB gene" downshifts complement(137038) /Source="Nicolas_upshifts" /id="D49" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="3.39972" /MaxDrop="4.09052" /score="-4.16840603" /energy="-12.8" /TU="NA" /idTUdmin="U99" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" CDS 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S19 (BS19)" /protein_id="NP_388001.1" /db_xref="EnsemblGenomes-Gn:BSU01200" /db_xref="EnsemblGenomes-Tr:CAB11896" /db_xref="GOA:P21476" /db_xref="InterPro:IPR002222" /db_xref="InterPro:IPR005732" /db_xref="InterPro:IPR020934" /db_xref="InterPro:IPR023575" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19011" /db_xref="UniProtKB/Swiss-Prot:P21476" /translation="MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQF IGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR*" /label="rpsS CDS" gene 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /label="rpsS gene" CDS 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7928988, 12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7928988, 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L22 (BL17)" /protein_id="NP_388002.1" /db_xref="EnsemblGenomes-Gn:BSU01210" /db_xref="EnsemblGenomes-Tr:CAB11897" /db_xref="GOA:P42060" /db_xref="InterPro:IPR001063" /db_xref="InterPro:IPR005727" /db_xref="InterPro:IPR018260" /db_xref="InterPro:IPR036394" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11078" /db_xref="UniProtKB/Swiss-Prot:P42060" /translation="MQAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAAS PIIEKVLKSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTSH ITIVVSEKKEG*" /label="rplV CDS" gene 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /label="rplV gene" CDS 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S3 (BS3)" /protein_id="NP_388003.2" /db_xref="EnsemblGenomes-Gn:BSU01220" /db_xref="EnsemblGenomes-Tr:CAB11898" /db_xref="GOA:P21465" /db_xref="InterPro:IPR001351" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR005704" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR018280" /db_xref="InterPro:IPR036419" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19005" /db_xref="UniProtKB/Swiss-Prot:P21465" /translation="MGQKVNPVGLRIGVIRDWESKWYAGKDYADFLHEDLKIREYISK RLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGGSEVEALRKALNSLTGKRVHINI LEIKRADLDAQLVADNIARQLENRVSFRRAQKQQIQRTMRAGAQGVKTMVSGRLGGAD IARSEYYSEGTVPLHTLRADIDYATSEADTTYGKLGVKVWIYRGEVLPTKKKNEEGGK *" /label="rpsC CDS" gene 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /label="rpsC gene" downshifts complement(138446) /Source="Nicolas_upshifts" /id="D50" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="3.68388" /MaxDrop="2.1922" /score="-4.16840603" /energy="-12.8" /TU="U99" /idTUdmin="U99" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(138527..138531) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(138534) /Source="Nicolas_upshifts" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(138548..138550) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L16" /protein_id="NP_388004.1" /db_xref="EnsemblGenomes-Gn:BSU01230" /db_xref="EnsemblGenomes-Tr:CAB11899" /db_xref="GOA:P14577" /db_xref="InterPro:IPR000114" /db_xref="InterPro:IPR016180" /db_xref="InterPro:IPR020798" /db_xref="InterPro:IPR036920" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10755" /db_xref="UniProtKB/Swiss-Prot:P14577" /translation="MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITN RQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKV LFEISGVSEEVAREALRLASHKLPIKTKFVKREEIGGESNES*" /label="rplP CDS" gene 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /label="rplP gene" CDS 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L29" /protein_id="NP_388005.1" /db_xref="EnsemblGenomes-Gn:BSU01240" /db_xref="EnsemblGenomes-Tr:CAB11900" /db_xref="GOA:P12873" /db_xref="InterPro:IPR001854" /db_xref="InterPro:IPR018254" /db_xref="InterPro:IPR036049" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10756" /db_xref="UniProtKB/Swiss-Prot:P12873" /translation="MKANEIRDLTTAEIEQKVKSLKEELFNLRFQLATGQLENTARIR EVRKAIARMKTVIREREIAANK*" /label="rpmC CDS" gene 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /label="rpmC gene" CDS 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S17 (BS16)" /protein_id="NP_388006.1" /db_xref="EnsemblGenomes-Gn:BSU01250" /db_xref="EnsemblGenomes-Tr:CAB11901" /db_xref="GOA:P12874" /db_xref="InterPro:IPR000266" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019979" /db_xref="InterPro:IPR019984" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10757" /db_xref="UniProtKB/Swiss-Prot:P12874" /translation="MSERNQRKVYQGRVVSDKMDKTITVVVETYKKHTLYGKRVKYSK KFKAHDENNQAKIGDIVKIMETRPLSATKRFRLVEVVEEAVII*" /label="rpsQ CDS" gene 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /label="rpsQ gene" CDS 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 8805509, 12682299, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 8805509, 12682299, 22829778; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L14" /protein_id="NP_388007.1" /db_xref="EnsemblGenomes-Gn:BSU01260" /db_xref="EnsemblGenomes-Tr:CAB11902" /db_xref="GOA:P12875" /db_xref="InterPro:IPR000218" /db_xref="InterPro:IPR005745" /db_xref="InterPro:IPR019972" /db_xref="InterPro:IPR036853" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10758" /db_xref="UniProtKB/Swiss-Prot:P12875" /translation="MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVK QATPGGVVKKGEVVKAVIVRTKSGARRSDGSYISFDENACVIIRDDKSPRGTRIFGPV ARELRENNFMKIVSLAPEVI*" /label="rplNA CDS" gene 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /label="rplNA gene" CDS 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11278078, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11278078, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L24 (BL23)" /protein_id="NP_388008.1" /db_xref="EnsemblGenomes-Gn:BSU01270" /db_xref="EnsemblGenomes-Tr:CAB11903" /db_xref="GOA:P0CI78" /db_xref="InterPro:IPR003256" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR005825" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10759" /db_xref="UniProtKB/Swiss-Prot:P0CI78" /translation="MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKH SKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLD K*" /label="rplX CDS" gene 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /label="rplX gene" CDS 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L5 (BL6)" /protein_id="NP_388009.1" /db_xref="EnsemblGenomes-Gn:BSU01280" /db_xref="EnsemblGenomes-Tr:CAB11904" /db_xref="GOA:P12877" /db_xref="InterPro:IPR002132" /db_xref="InterPro:IPR020929" /db_xref="InterPro:IPR020930" /db_xref="InterPro:IPR022803" /db_xref="InterPro:IPR031309" /db_xref="InterPro:IPR031310" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10760" /db_xref="UniProtKB/Swiss-Prot:P12877" /translation="MNRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAV QNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDK LISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTA NTDEEARELLTQVGMPFQK*" /label="rplE CDS" gene 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /label="rplE gene" CDS 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17163968, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17163968, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S14" /protein_id="NP_388010.1" /db_xref="EnsemblGenomes-Gn:BSU01290" /db_xref="EnsemblGenomes-Tr:CAB11905" /db_xref="GOA:P12878" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023053" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10761" /db_xref="UniProtKB/Swiss-Prot:P12878" /translation="MAKKSMIAKQQRTPKFKVQEYTRCERCGRPHSVIRKFKLCRICF RELAYKGQIPGVKKASW*" /label="rpsNA CDS" gene 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /label="rpsNA gene" CDS 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S8 (BS8)" /protein_id="NP_388011.2" /db_xref="EnsemblGenomes-Gn:BSU01300" /db_xref="EnsemblGenomes-Tr:CAB11906" /db_xref="GOA:P12879" /db_xref="InterPro:IPR000630" /db_xref="InterPro:IPR035987" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10762" /db_xref="UniProtKB/Swiss-Prot:P12879" /translation="MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREG FIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLG IAIISTSQGVLTDKEARAKQAGGEVLAYVW*" /label="rpsH CDS" gene 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /label="rpsH gene" downshifts complement(141966) /Source="Nicolas_upshifts" /id="D51" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="2.68318" /MaxDrop="2.55712" /score="5.40276403" /energy="-15.9" /TU="NA" /idTUdmin="U99" /TUdmin="-3586" /isTUend="FALSE" /label="downshifts" CDS 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 25330043; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L6 (BL8)" /protein_id="NP_388012.1" /db_xref="EnsemblGenomes-Gn:BSU01310" /db_xref="EnsemblGenomes-Tr:CAB11907" /db_xref="GOA:P46898" /db_xref="InterPro:IPR000702" /db_xref="InterPro:IPR002358" /db_xref="InterPro:IPR019906" /db_xref="InterPro:IPR020040" /db_xref="InterPro:IPR036789" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11408" /db_xref="UniProtKB/Swiss-Prot:P46898" /translation="MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEI KVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGN KLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKG KGIRYEGEVVRRKEGKSAK*" /label="rplF CDS" gene 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /label="rplF gene" CDS 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L18" /protein_id="NP_388013.2" /db_xref="EnsemblGenomes-Gn:BSU01320" /db_xref="EnsemblGenomes-Tr:CAB11908" /db_xref="GOA:P46899" /db_xref="InterPro:IPR004389" /db_xref="InterPro:IPR005484" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11409" /db_xref="UniProtKB/Swiss-Prot:P46899" /translation="MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQI IDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLY HGRVKALADAAREAGLKF*" /label="rplR CDS" gene 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /label="rplR gene" CDS 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6211592, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6211592, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S5" /protein_id="NP_388014.1" /db_xref="EnsemblGenomes-Gn:BSU01330" /db_xref="EnsemblGenomes-Tr:CAB11909" /db_xref="GOA:P21467" /db_xref="InterPro:IPR000851" /db_xref="InterPro:IPR005324" /db_xref="InterPro:IPR005712" /db_xref="InterPro:IPR013810" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018192" /db_xref="InterPro:IPR020568" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10442" /db_xref="UniProtKB/Swiss-Prot:P21467" /translation="MRRIDPSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNG HVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNILLKPASEG TGVIAGGPVRAVLELAGVADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKS VEELLG*" /label="rpsE CDS" gene 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /label="rpsE gene" CDS 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L30 (BL27)" /protein_id="NP_388015.1" /db_xref="EnsemblGenomes-Gn:BSU01340" /db_xref="EnsemblGenomes-Tr:CAB11910" /db_xref="GOA:P19947" /db_xref="InterPro:IPR005996" /db_xref="InterPro:IPR016082" /db_xref="InterPro:IPR018038" /db_xref="InterPro:IPR036919" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10443" /db_xref="UniProtKB/Swiss-Prot:P19947" /translation="MAKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIR GMINKVSHLVSVKEQ*" /label="rpmD CDS" gene 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /label="rpmD gene" CDS 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15855514, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15855514, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L15" /protein_id="NP_388016.1" /db_xref="EnsemblGenomes-Gn:BSU01350" /db_xref="EnsemblGenomes-Tr:CAB11911" /db_xref="GOA:P19946" /db_xref="InterPro:IPR001196" /db_xref="InterPro:IPR005749" /db_xref="InterPro:IPR021131" /db_xref="InterPro:IPR030878" /db_xref="InterPro:IPR036227" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10444" /db_xref="UniProtKB/Swiss-Prot:P19946" /translation="MKLHELKPSEGSRKTRNRVGRGIGSGNGKTAGKGHKGQNARSGG GVRPGFEGGQMPLFQRLPKRGFTNINRKEYAVVNLDKLNGFAEGTEVTPELLLETGVI SKLNAGVKILGNGKLEKKLTVKANKFSASAKEAVEAAGGTAEVI*" /label="rplO CDS" gene 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /label="rplO gene" CDS 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478; Product type t: transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_388017.1" /db_xref="EnsemblGenomes-Gn:BSU01360" /db_xref="EnsemblGenomes-Tr:CAB11912" /db_xref="GOA:P16336" /db_xref="InterPro:IPR002208" /db_xref="InterPro:IPR023201" /db_xref="InterPro:IPR026593" /db_xref="InterPro:IPR030659" /db_xref="SubtiList:BG10445" /db_xref="UniProtKB/Swiss-Prot:P16336" /translation="MFKTISNFMRVSDIRNKIIFTLLMLIVFRIGAFIPVPYVNAEAL QAQSQMGVFDLLNTFGGGALYQFSIFAMGITPYITASIIIQLLQMDVVPKFTEWSKQG EVGRRKLAQFTRYFTIVLGFIQALGMSYGFNNLANGMLIEKSGVSTYLIIALVLTGGT AFLMWLGEQITSHGVGNGISIIIFAGIVSSIPKTIGQIYETQFVGSNDQLFIHIVKVA LLVIAILAVIVGVIFIQQAVRKIAIQYAKGTGRSPAGGGQSTHLPLKVNPAGVIPVIF AVAFLITPRTIASFFGTNDVTKWIQNNFDNTHPVGMAIYVALIIAFTYFYAFVQVNPE QMADNLKKQGGYIPGVRPGKMTQDRITSILYRLTFVGSIFLAVISILPIFFIQFAGLP QSAQIGGTSLLIVVGVALETMKQLESQLVKRNYRGFMKN*" /label="secY CDS" gene 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /label="secY gene" CDS 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /EC_number="2.7.4.3" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8061005, 8288548, 9056261, 9715904, 11106368, 16452168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8061005, 8288548, 9056261, 9715904, 11106368, 16452168; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate kinase" /protein_id="NP_388018.1" /db_xref="EnsemblGenomes-Gn:BSU01370" /db_xref="EnsemblGenomes-Tr:CAB11913" /db_xref="GOA:P16304" /db_xref="InterPro:IPR000850" /db_xref="InterPro:IPR006259" /db_xref="InterPro:IPR007862" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033690" /db_xref="PDB:1P3J" /db_xref="PDB:2EU8" /db_xref="PDB:2OO7" /db_xref="PDB:2ORI" /db_xref="PDB:2OSB" /db_xref="PDB:2P3S" /db_xref="PDB:2QAJ" /db_xref="PDB:3DKV" /db_xref="PDB:3DL0" /db_xref="PDB:4MKF" /db_xref="PDB:4MKG" /db_xref="PDB:4MKH" /db_xref="PDB:4QBF" /db_xref="PDB:4QBG" /db_xref="PDB:4TYP" /db_xref="PDB:4TYQ" /db_xref="SubtiList:BG10446" /db_xref="UniProtKB/Swiss-Prot:P16304" /translation="MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETP LGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEE YGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQR ADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK* " /label="adk CDS" gene 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /label="adk gene" CDS 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16207374, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase" /protein_id="NP_388019.1" /db_xref="EnsemblGenomes-Gn:BSU01380" /db_xref="EnsemblGenomes-Tr:CAB11914" /db_xref="GOA:P19994" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG10447" /db_xref="UniProtKB/Swiss-Prot:P19994" /translation="MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIA ERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGY HGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFS VVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNW TVVTVDGKKCAHFEHTIAITETGFDILTRV*" /label="mapA CDS" gene 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /label="mapA gene" CDS 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17157877; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative ribosome binding protein" /protein_id="YP_003097669.1" /db_xref="EnsemblGenomes-Gn:BSU01389" /db_xref="EnsemblGenomes-Tr:CAX52539" /db_xref="UniProtKB/Swiss-Prot:C0H3S8" /translation="MIGQKAWVNIGKTEFILLLVVGILTIINVLTADGEKRTFHSPKK KNINHLTLYDCVSPEVQNSINETGRVTNFF*" /label="ybzG CDS" gene 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /label="ybzG gene" CDS 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9868784, 20477873, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-I" /protein_id="NP_388020.1" /db_xref="EnsemblGenomes-Gn:BSU01390" /db_xref="EnsemblGenomes-Tr:CAB11915" /db_xref="GOA:P20458" /db_xref="InterPro:IPR004368" /db_xref="InterPro:IPR006196" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11043" /db_xref="UniProtKB/Swiss-Prot:P20458" /translation="MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHF IRILPGDKVTVELSPYDLTRGRITYRYK*" /label="infA CDS" gene 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /label="infA gene" CDS 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1783905, 23002217, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1783905, 23002217, 24335279; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L36 (ribosomal protein B)" /protein_id="NP_388021.1" /db_xref="EnsemblGenomes-Gn:BSU01400" /db_xref="EnsemblGenomes-Tr:CAB11916" /db_xref="GOA:P20278" /db_xref="InterPro:IPR000473" /db_xref="InterPro:IPR035977" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11042" /db_xref="UniProtKB/Swiss-Prot:P20278" /translation="MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG*" /label="rpmJ CDS" gene 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /label="rpmJ gene" CDS 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S13" /protein_id="NP_388022.2" /db_xref="EnsemblGenomes-Gn:BSU01410" /db_xref="EnsemblGenomes-Tr:CAB11917" /db_xref="GOA:P20282" /db_xref="InterPro:IPR001892" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR018269" /db_xref="InterPro:IPR019980" /db_xref="InterPro:IPR027437" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10730" /db_xref="UniProtKB/Swiss-Prot:P20282" /translation="MARIAGVDIPRDKRVVISLTYIFGIGRTTAQQVLKEAGVSEDTR VRDLTEEELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNS KNNARTRKGPRRTVANKKK*" /label="rpsM CDS" gene 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /label="rpsM gene" CDS 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217780, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217780, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S11 (BS11)" /protein_id="NP_388023.1" /db_xref="EnsemblGenomes-Gn:BSU01420" /db_xref="EnsemblGenomes-Tr:CAB11918" /db_xref="GOA:P04969" /db_xref="InterPro:IPR001971" /db_xref="InterPro:IPR018102" /db_xref="InterPro:IPR019981" /db_xref="InterPro:IPR036967" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10731" /db_xref="UniProtKB/Swiss-Prot:P04969" /translation="MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAI SWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRAL QAAGLEVTAIRDVTPVPHNGCRPPKRRRV*" /label="rpsK CDS" gene 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /label="rpsK gene" S_feature 148346..148521 /Source="Nicolas_S_feature" /locus_tag="new_148755_148930" /HighExp="G135, dia5, Lbexp, S0, aero, dia0, T-4.40H, G150, Paraq, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S56" CDS 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1484484, 6811591, 9594570, 10972808, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1484484, 6811591, 9594570, 10972808, 12682299, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (alpha subunit)" /protein_id="NP_388024.1" /db_xref="EnsemblGenomes-Gn:BSU01430" /db_xref="EnsemblGenomes-Tr:CAB11919" /db_xref="GOA:P20429" /db_xref="InterPro:IPR011260" /db_xref="InterPro:IPR011262" /db_xref="InterPro:IPR011263" /db_xref="InterPro:IPR011773" /db_xref="InterPro:IPR036603" /db_xref="InterPro:IPR036643" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG10732" /db_xref="UniProtKB/Swiss-Prot:P20429" /translation="MIEIEKPKIETVEISDDAKFGKFVVEPLERGYGTTLGNSLRRIL LSSLPGAAVTSIQIDGVLHEFSTIEGVVEDVTTIILHIKKLALKIYSDEEKTLEIDVQ GEGTVTAADITHDSDVEILNPDLHIATLGENASFRVRLTAQRGRGYTPADANKRDDQP IGVIPIDSIYTPVSRVSYQVENTRVGQVANYDKLTLDVWTDGSTGPKEAIALGSKILT EHLNIFVGLTDEAQHAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQE LANKTEEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD*" /label="rpoA CDS" gene 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /label="rpoA gene" CDS 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6801428, 10717392, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6801428, 10717392, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L17 (BL15)" /protein_id="NP_388025.1" /db_xref="EnsemblGenomes-Gn:BSU01440" /db_xref="EnsemblGenomes-Tr:CAB11920" /db_xref="GOA:P20277" /db_xref="InterPro:IPR000456" /db_xref="InterPro:IPR036373" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11041" /db_xref="UniProtKB/Swiss-Prot:P20277" /translation="MSYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVV EKMITLGKRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRIM KLGPRRGDGAPMAIIELV*" /label="rplQ CDS" gene 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /label="rplQ gene" downshifts 149908 /Source="Nicolas_upshifts" /id="D52" /incds=0 /nref=171 /ntot=259 /MaxReadThrough="7.50771" /MaxDrop="5.4374" /score="2.32634618" /energy="-10.5" /TU="U98" /idTUdmin="U98" /TUdmin="-5577" /isTUend="FALSE" /label="downshifts" S_feature 149953..150033 /Source="Nicolas_S_feature" /locus_tag="new_150362_150442" /HighExp="Cold, G180, G135, G150, H2O2, S0, C30, Oxctl, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S57" CDS 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388026.2" /db_xref="EnsemblGenomes-Gn:BSU01450" /db_xref="EnsemblGenomes-Tr:CAB11921" /db_xref="GOA:P40735" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030947" /db_xref="SubtiList:BG11067" /db_xref="UniProtKB/Swiss-Prot:P40735" /translation="MNQNQLISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHN GSGKSTLARALNGLILPESGDIEVAGIQLTEESVWEVRKKIGMVFQNPDNQFVGTTVR DDVAFGLENNGVPREEMIERVDWAVKQVNMQDFLDQEPHHLSGGQKQRVAIAGVIAAR PDIIILDEATSMLDPIGREEVLETVRHLKEQGMATVISITHDLNEAAKADRIIVMNGG KKYAEGPPEEIFKLNKELVRIGLDLPFSFQLSQLLRENGLALEENHLTQEGLVKELWT LQSKM*" /label="ecfA CDS" gene 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /label="ecfA gene" CDS 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12110480, 21135102, 26052893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388027.1" /db_xref="EnsemblGenomes-Gn:BSU01460" /db_xref="EnsemblGenomes-Tr:CAB11922" /db_xref="GOA:P70970" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030946" /db_xref="SubtiList:BG11989" /db_xref="UniProtKB/Swiss-Prot:P70970" /translation="MKTPFERLALYDINASIKEGSYVAVIGHTGSGKSTLLQHLNGLL KPTKGQISLGSTVIQAGKKNKDLKKLRKKVGIVFQFPEHQLFEETVLKDISFGPMNFG VKKEDAEQKAREMLQLVGLSEELLDRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPT AGLDPRGRKEIMDMFYELHQRGNLTTILVTHSMEDAAAYADEMIVMHKGTIQASGSPR DLFLKGEEMAGWGLDLPETIKFQRHLEAALGVRFNEPMLTIEDAAAEIRALFQGEKTL *" /label="ecfAB CDS" gene 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /label="ecfAB gene" CDS 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18931129, 21135102, 26052893; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the influx ECF transporters" /protein_id="NP_388028.2" /db_xref="EnsemblGenomes-Gn:BSU01470" /db_xref="EnsemblGenomes-Tr:CAB11923" /db_xref="GOA:P70972" /db_xref="InterPro:IPR003339" /db_xref="InterPro:IPR024919" /db_xref="SubtiList:BG11990" /db_xref="UniProtKB/Swiss-Prot:P70972" /translation="MMDSMIIGKYVPGTSLVHRLDPRTKLITIFLFVCIVFLANNVQT YALLGLFTIGVVSLTRVPFSFLMKGLKPIIWIVLFTFLLHILMTHEGPIIFQIGFFKV YEGGLVQGIFISLRFVYLILITTLLTLTTTPIEITDGMEQLLNPLKKLKLPVHELALM MSISLRFIPTLMEETDKIMKAQMARGVDFTSGPVKERVKAIVPLLVPLFVSAFKRAEE LAVAMEARGYQGGEGRTKYRKLVWTGKDTSVIVSLIVLAALLFFLRA*" /label="ecfT CDS" gene 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /label="ecfT gene" CDS 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /EC_number="5.4.99.12" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10529181, 15353568, 17114947, 17466622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine (38-40) synthase" /protein_id="NP_388029.2" /db_xref="EnsemblGenomes-Gn:BSU01480" /db_xref="EnsemblGenomes-Tr:CAB11924" /db_xref="GOA:P70973" /db_xref="InterPro:IPR001406" /db_xref="InterPro:IPR020095" /db_xref="InterPro:IPR020097" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG11992" /db_xref="UniProtKB/Swiss-Prot:P70973" /translation="MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRI PVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHA RFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAA KTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVK SMLEAKDREAAGRTAPGHGLYLWNVYYDN*" /label="truA CDS" gene 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /label="truA gene" S_feature complement(152630..153098) /Source="Nicolas_S_feature" /locus_tag="new_153039_153507_c" /HighExp="S6, S8, S7, C30, G135, BT, S5, C90, M/G, Pyr" /AntisenseName="truA" /AntisenseCor="-0.30232258010971202" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S58" promotor_-35 152763..152768 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 152783..152800 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 152802 /Source="Nicolas_upshifts" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(153098..153117) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(153120) /Source="Nicolas_upshifts" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(153130..153139) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 153291..153297 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153312..153331 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153316 /Source="Nicolas_upshifts" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /product="putative L13_leader" /note="Evidence 3: Putative function from multiple computational evidences; Product type n: RNA" /label="ldlM RNA" gene 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /label="ldlM gene" CDS 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 23504016, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 23504016, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L13" /protein_id="NP_388030.2" /db_xref="EnsemblGenomes-Gn:BSU01490" /db_xref="EnsemblGenomes-Tr:CAB11925" /db_xref="GOA:P70974" /db_xref="InterPro:IPR005822" /db_xref="InterPro:IPR005823" /db_xref="InterPro:IPR023563" /db_xref="InterPro:IPR036899" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11970" /db_xref="UniProtKB/Swiss-Prot:P70974" /translation="MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPT YTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKML ELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG*" /label="rplM CDS" gene 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /label="rplM gene" CDS 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 19653700, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S9" /protein_id="NP_388031.1" /db_xref="EnsemblGenomes-Gn:BSU01500" /db_xref="EnsemblGenomes-Tr:CAB11926" /db_xref="GOA:P21470" /db_xref="InterPro:IPR000754" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020574" /db_xref="InterPro:IPR023035" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19007" /db_xref="UniProtKB/Swiss-Prot:P21470" /translation="MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREISEHIPSAAL IEDIKQPLTLTETAGTYDVLVNVHGGGLSGQAGAIRHGIARALLEADPEYRTTLKRAG LLTRDARMKERKKYGLKGARRAPQFSKR*" /label="rpsI CDS" gene 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /label="rpsI gene" downshifts 154258 /Source="Nicolas_upshifts" /id="D53" /incds=0 /nref=262 /ntot=282 /MaxReadThrough="4.65387" /MaxDrop="8.11906" /score="30.5093496" /energy="-13.3" /TU="U98,U100,U102" /idTUdmin="U98" /TUdmin="-1227" /isTUend="FALSE" /label="downshifts" promotor_-35 154400..154407 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 154421..154440 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 154429..154710 /Source="Nicolas_S_feature" /locus_tag="new_154838_155119" /HighExp="H2O2, G180, G135, Paraq, Diami, dia15, Oxctl, Cold, Heat, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.479, 1" /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S59" upshifts 154429 /Source="Nicolas_upshifts" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature 154709..154728 /Source="Nicolas_upshift_promotors" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 154712 /Source="Nicolas_upshifts" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26582911; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388032.2" /db_xref="EnsemblGenomes-Gn:BSU01510" /db_xref="EnsemblGenomes-Tr:CAB11927" /db_xref="GOA:P70976" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11994" /db_xref="UniProtKB/Swiss-Prot:P70976" /translation="MNALVAHNSKAWDKKVETGNEWTVAVEQQVIEQAKKGNWDIRVT PMKDVPKDWFPPIKGLKVLCLASGGGQQGPVLAAAGADVTVLDNSEKQLNQDRMIAER DGLTIHTVKGSMDDLSVFNDESFDVIVHPVANVFVENVLPVWKEAYRVLKRNGILISG FVNPVVFLFDTELEQQGVLKVKHSIPYADPEDLPKHKVKKLIENNEALEFGHSLEDQI KGQIDAGFIVTGFYEDKGGFVLDQYIHTYSATRSVKV*" /label="ybaJ CDS" gene 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /label="ybaJ gene" downshifts 155505 /Source="Nicolas_upshifts" /id="D54" /incds=0 /nref=215 /ntot=251 /MaxReadThrough="2.69346" /MaxDrop="6.09641" /score="4.42269359" /energy="-10.3" /TU="NA" /idTUdmin="U100" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 155644..155650 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 155665..155676 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 155672 /Source="Nicolas_upshifts" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679227, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388033.1" /db_xref="EnsemblGenomes-Gn:BSU01520" /db_xref="EnsemblGenomes-Tr:CAB11928" /db_xref="GOA:P50862" /db_xref="InterPro:IPR019667" /db_xref="SubtiList:BG11503" /db_xref="UniProtKB/Swiss-Prot:P50862" /translation="MAEVLSFMDVKRQKDFELEKNLLKELSLRQIIQSVKDCLEPLFP FLHDERDIITEGCIDFAIEAYLLGGRFGIFGYYGESMQSISARSAREEEELRMEFFDY LYNWIHEQYATFDKNTVYEAARKFIKDWWTAGFVQREKQCKLRMR*" /label="ybaK CDS" gene 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /label="ybaK gene" promotor_-35 156143..156148 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156164..156182 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156165 /Source="Nicolas_upshifts" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /EC_number="3.5.1.28" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_388034.1" /db_xref="EnsemblGenomes-Gn:BSU01530" /db_xref="EnsemblGenomes-Tr:CAB11929" /db_xref="GOA:P50864" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR014234" /db_xref="SubtiList:BG11514" /db_xref="UniProtKB/Swiss-Prot:P50864" /translation="MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIY LDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKG YSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYI QDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVA SSIYKGILRYFTEKGDPPE*" /label="cwlD CDS" gene 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /label="cwlD gene" upshifts 156961 /Source="Nicolas_upshifts" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="upshifts" misc_feature 156964..156983 /Source="Nicolas_upshift_promotors" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11790741, 15126467, 26094643" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11790741, 15126467, 26094643; Product type r: regulator" /codon_start=1 /transl_table=11 /product="phosphorylation-dependent (Y327) transcriptionalregulator" /protein_id="NP_388035.1" /db_xref="EnsemblGenomes-Gn:BSU01540" /db_xref="EnsemblGenomes-Tr:CAB11930" /db_xref="GOA:P50863" /db_xref="InterPro:IPR000808" /db_xref="InterPro:IPR019591" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG11494" /db_xref="UniProtKB/Swiss-Prot:P50863" /translation="MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVK VALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNM DNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRP TIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVL DLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMA YYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIG EIYQDIAKKIDAKMSVQV*" /label="salA CDS" gene 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /label="salA gene" S_feature complement(157641..158105) /Source="Nicolas_S_feature" /locus_tag="new_158050_158514_c" /HighExp="S8, S7, S6, S5, C30, S4, C90, nit, ferm, Gly" /AntisenseName="salA" /AntisenseCor="-0.104183954485248" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S60" downshifts 158056 /Source="Nicolas_upshifts" /id="D55" /incds=0 /nref=29 /ntot=155 /MaxReadThrough="5.44939" /MaxDrop="4.18382" /score="-4.46878413" /energy="-9.1" /TU="U107" /idTUdmin="U106" /TUdmin=1185 /isTUend="FALSE" /label="downshifts" S_feature 158101..158772 /Source="Nicolas_S_feature" /locus_tag="new_158510_159181" /HighExp="Lbtran, H2O2, Cold, Lbstat, dia5, M40t45, M0t90, M40t90, T0.30H, S1" /AntisenseName="gerD" /AntisenseCor="-0.24235509346425901" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S61" CDS complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17122337, 10618233, 10376819, 24530795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17122337, 10618233, 10376819, 24530795; Product type f: factor" /codon_start=1 /transl_table=11 /product="lipoprotein factor mediating clustering of germination proteins" /protein_id="NP_388036.1" /db_xref="EnsemblGenomes-Gn:BSU01550" /db_xref="EnsemblGenomes-Tr:CAB11931" /db_xref="GOA:P16450" /db_xref="SubtiList:BG10644" /db_xref="UniProtKB/Swiss-Prot:P16450" /translation="MSKAKTLLMSCFLLLSVTACAPKDQAADMDYDQTKKMVVDILKT DDGKKAIKELLNDDAMNEALVIDQDAIKGTIEKTLTSKKGEEFWKNIFEDTDFAEGFA KTLQTEHEKVIKKLMKDPDYQKMLMSVMQDPGMDKKYSQLAKSQEFRSYLEEVINETL SSPLYKKQFEDELKKAAKDTAKESE*" /label="gerD CDS" gene complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /label="gerD gene" promotor_-10 complement(158695..158706) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(158707) /Source="Nicolas_upshifts" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(158720..158726) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(158740..159369) /Source="Nicolas_S_feature" /locus_tag="new_159149_159778_c" /HighExp="S3, T5.0H, S4, S8, M9-stat, T4.0H, T3.30H, S7, T3.0H, S6" /AntisenseName="kbaA" /AntisenseCor="7.9344921760152495E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S62" CDS 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8576055, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576055, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inner membrane protein involved in activation ofthe KinB signaling pathway to sporulation" /protein_id="NP_388037.1" /db_xref="EnsemblGenomes-Gn:BSU01560" /db_xref="EnsemblGenomes-Tr:CAB11932" /db_xref="GOA:P16449" /db_xref="InterPro:IPR024164" /db_xref="SubtiList:BG10643" /db_xref="UniProtKB/Swiss-Prot:P16449" /translation="MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQ IFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDL MYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITAL EWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK*" /label="kbaA CDS" gene 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /label="kbaA gene" S_feature 159370..160264 /Source="Nicolas_S_feature" /locus_tag="new_159779_160673" /HighExp="Lbstat, Lbtran, M0t90, M40t90, H2O2, BC, Glucon, S7, M40t45, S1" /AntisenseName="ybaN" /AntisenseCor="-2.6735901031407501E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S63" CDS complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 15598884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 15598884; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="polysaccharide deacetylase involved in sporulation" /protein_id="NP_388038.1" /db_xref="EnsemblGenomes-Gn:BSU01570" /db_xref="EnsemblGenomes-Tr:CAB11933" /db_xref="GOA:P50865" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014132" /db_xref="SubtiList:BG11416" /db_xref="UniProtKB/Swiss-Prot:P50865" /translation="MNHFYVWHIKRVKQLIIILIAAFAAASFFYIQRAVPLPVFSTDT GPKAIYKGETDSKDISLTFDISWGDERAEPILNTLKANGIKNATFFLSASWAERHPDT VARIVKDGHQIGSMGYAYKNYANLESSEIKKDMNRAQTAFEKLGVKDIQLLRPPTGQF NKNVLKVAKQYNYTVVHYSVNSQDWTNPGVEKIIDNVTKQVSGGDIILLHASDSAKQT EEALPDIIHQLKEKGLKNVTVGDLIANSDAKSAEVK*" /label="pdaB CDS" gene complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /label="pdaB gene" promotor_-10 complement(160165..160183) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(160185) /Source="Nicolas_upshifts" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(160199..160204) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 160242..160249 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 160264..160283 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 160266..160483 /Source="Nicolas_S_feature" /locus_tag="new_160675_160892" /HighExp="Diami, LBGstat, UNK1, H2O2, MG 15, Oxctl, MG-0.1, BMM, T-1.10H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S64" upshifts 160266 /Source="Nicolas_upshifts" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-16S rRNA" gene 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /modified_by="User" /label="rrnI-16S gene" Polymorphism join(160830,160832) /Source="geneious" /ID="SNP_BsDelta6_161240_161239" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=45 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value="4.2e-57" /Variant_Raw_Frequency=41 /comment="rrnI-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-23S rRNA" gene 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /label="rrnI-23S gene" rRNA 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /product="ribosomal RNA-5S" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-5S rRNA" gene 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /label="rrnI-5S gene" Polymorphism join(165341,165342) /Source="geneious" /ID="SNP_BsDelta6_165748_165749" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="-TC" /Codon_Change /Coverage="172 -> 174" /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TC" /Variant_Nucleotides /Variant_P_Value="1.5e-307" /Variant_Raw_Frequency=152 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(165342,165344) /Source="geneious" /ID="SNP_BsDelta6_165751_165751" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="C -> T" /Codon_Change /Coverage=172 /locus_tag /Protein_Effect /Reference_Frequency="1.2%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=168 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Asn tRNA" gene 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /label="trnI-Asn gene" Polymorphism join(165417,165419) /Source="geneious" /ID="SNP_BsDelta6_165826_165825" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=163 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=160 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(GGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Thr tRNA" gene 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /label="trnI-Thr gene" tRNA 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Gly tRNA" gene 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /label="trnI-Gly gene" Polymorphism join(165630,165632) /Source="geneious" /ID="SNP_BsDelta6_166038_166037" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="T" /Codon_Change /Coverage=154 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=148 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg(AGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Arg tRNA" gene 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /label="trnI-Arg gene" tRNA 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Pro tRNA" gene 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /label="trnI-Pro gene" tRNA 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Ala tRNA" gene 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /label="trnI-Ala gene" Polymorphism join(165937,165938) /Source="geneious" /ID="SNP_BsDelta6_166344_166344" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-G" /Codon_Change /Coverage=132 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides /Variant_P_Value="4.9e-75" /Variant_Raw_Frequency=130 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-16S rRNA" gene 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /label="rrnH-16S gene" rRNA 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-23S rRNA" gene 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /label="rrnH-23S gene" rRNA 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-5S rRNA" gene 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /label="rrnH-5S gene" rRNA 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-16S rRNA" gene 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /label="rrnG-16S gene" rRNA 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-23S rRNA" gene 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /label="rrnG-23S gene" rRNA 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-5S rRNA" gene 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /label="rrnG-5S gene" S_feature 175915..176523 /Source="Nicolas_S_feature" /locus_tag="new_176316_176924" /HighExp="G180, G135, C30, Oxctl, Paraq, Cold, G150, H2O2, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S65" promotor_-35 176491..176495 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 176511..176530 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 176525..176681 /Source="Nicolas_S_feature" /locus_tag="new_176926_177082" /HighExp="LBGstat, G180, G135, dia15, C30, Oxctl, LPhT, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S66" upshifts 176525 /Source="Nicolas_upshifts" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="upshifts" CDS 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388039.1" /db_xref="EnsemblGenomes-Gn:BSU01580" /db_xref="EnsemblGenomes-Tr:CAB11934" /db_xref="GOA:P55189" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR018045" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11562" /db_xref="UniProtKB/Swiss-Prot:P55189" /translation="MNNSFTLKQQWFGNIRKDILAGILVALALIPEAIGFSIIAGVDP MVGLYASFCIAIIISIFGGRPGMISAATGSMAVVMVSLVADHGLQYLFAATILTGIIQ VILGISKIARLMKFIPRSVMIGFVNALAILIFSAQLPQFEGASWSMYAMLAGSLVIIY VLPRFTTAVPSPLVAIIVMTIIAVTFHVDVRTVGDMGNISSSLPHFLIPDVPFTFETL QIIFPYSIALAFVGLLESLLTAQIIDEMTDTDSDKNKESRGQGIANIVTGFFGGMAGC AMIGQSVINTKAGGRGRLSAFVAGAFLMFLIAVLSHVVVKIPMAALVAVMVMVSVGTF DWSSLKGLKKAPLTDSIVMVVTVVTVVVTDDLSKGVFVGVLLSAVFFVAKISKLKIVS HAEDQKLRTYQVKGQIFFASVTDLTNAFIYQEDIERVVIDLTEAHVWDDSGAAALDKI VAKFKEQGIEAELKGLNKASKSLMKQMA*" /label="ybaR CDS" gene 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /label="ybaR gene" downshifts 178107 /Source="Nicolas_upshifts" /id="D56" /incds=0 /nref=144 /ntot=228 /MaxReadThrough="2.81758" /MaxDrop="4.71162" /score="18.4600501" /energy="-12" /TU="NA" /idTUdmin="U111" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 178161..178166 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 178179..178198 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 178197 /Source="Nicolas_upshifts" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="upshifts" CDS 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium dependent transporter" /protein_id="NP_388040.2" /db_xref="EnsemblGenomes-Gn:BSU01590" /db_xref="EnsemblGenomes-Tr:CAB11935" /db_xref="GOA:P55190" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG11563" /db_xref="UniProtKB/Swiss-Prot:P55190" /translation="MPLLTPTSVVLGVLLSQFLNGYEWAVPWIFAFITFAGSLSANFQ SLRHALSHPLPMILALFVLHIFMPLFAWGSGHLIFKGDPLTITGLTLAVVIPTGITSL IWAAMYKGNVGLTLSIILVDTVLSPLIVPLSLSLLAGAQVHMDVWGMMKGLIVMVVIP SFLGMLFNQMSSPERTAFVSSALSPFSKLCLMAVIAINSSAIAPYFKSIDLRFAGIAV TVFFIALTGYAAAWLIGKMMKRRQEEIVSLIFTGGMRNISAGAVLAVTFFPSQVAVPV VIGMLFQQILAALFGYMLNRFELKPMLQKA*" /label="ybaS CDS" gene 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /label="ybaS gene" downshifts 179165 /Source="Nicolas_upshifts" /id="D57" /incds=0 /nref=33 /ntot=224 /MaxReadThrough="1.3063" /MaxDrop="3.58628" /score="13.3102824" /energy="-10.5" /TU="NA" /idTUdmin="U112" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 2974033, 17725565, 22210890, 28283524" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 2974033, 17725565, 22210890, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-chelator (enterobactin family) esterase" /protein_id="NP_388041.2" /db_xref="EnsemblGenomes-Gn:BSU01600" /db_xref="EnsemblGenomes-Tr:CAB11936" /db_xref="GOA:P55192" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11565" /db_xref="UniProtKB/Swiss-Prot:P55192" /translation="MKGSLSEHKAGNRRFTLYLPPSYSTDSGGFPAVYVQDGSSLFQN QIELLESAFQQQRLPELVLIGIEPENRLDEYTPWPAASLSDRFTDFGGMGYHYLSDIT NQFIPLIEENWNVTREPQSRGMIGASLGGLISMFAILKYPSMFGKIGSISGSYWYENA AETIHISSLKPGTARVFMSIGSEEGREKQSIQRHMLKKTKQVHQSLKEKGFTEDQLCL SIEKGAVHHHKYFCKQFINALEWLYGKNRSTL*" /label="eesA CDS" gene complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /label="eesA gene" downshifts complement(179218) /Source="Nicolas_upshifts" /id="D58" /incds=0 /nref=15 /ntot=115 /MaxReadThrough="0.3819" /MaxDrop="4.57603" /score="25.9728338" /energy="-10.5" /TU="NA" /idTUdmin="U114" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2651410, 15849754, 16850406, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-uptake protein" /protein_id="NP_388042.2" /db_xref="EnsemblGenomes-Gn:BSU01610" /db_xref="EnsemblGenomes-Tr:CAB11937" /db_xref="GOA:P40411" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10837" /db_xref="UniProtKB/Swiss-Prot:P40411" /translation="MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQ YEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFM LLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSG FSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLD TIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGV EHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGE NA*" /label="feuC CDS" gene complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /label="feuC gene" CDS complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2651410, 15849754, 16850406, 17725565; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin permease" /protein_id="NP_388043.1" /db_xref="EnsemblGenomes-Gn:BSU01620" /db_xref="EnsemblGenomes-Tr:CAB11938" /db_xref="GOA:P40410" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10836" /db_xref="UniProtKB/Swiss-Prot:P40410" /translation="MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIH FDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAF IITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSML LSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAV SLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDY SRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG *" /label="feuB CDS" gene complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /label="feuB gene" CDS complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8388528, 16889643, 17725565, 21802011, 22303020, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8388528, 16889643, 17725565, 21802011, 22303020, 25355936; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin-binding lipoprotein" /protein_id="NP_388044.1" /db_xref="EnsemblGenomes-Gn:BSU01630" /db_xref="EnsemblGenomes-Tr:CAB11939" /db_xref="GOA:P40409" /db_xref="InterPro:IPR002491" /db_xref="PDB:2PHZ" /db_xref="PDB:2WHY" /db_xref="PDB:2WI8" /db_xref="PDB:2XUZ" /db_xref="PDB:2XV1" /db_xref="SubtiList:BG10835" /db_xref="UniProtKB/Swiss-Prot:P40409" /translation="MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYL DKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGE KMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLT GKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYG DLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWK SLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN*" /label="feuA CDS" gene complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /label="feuA gene" promotor_-35 182282..182288 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 182303..182321 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 182312 /Source="Nicolas_upshifts" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(182953..182972) /Source="Nicolas_upshift_promotors" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(182960) /Source="Nicolas_upshifts" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16889643, 17725565, 17962296, 22210890" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16889643, 17725565, 17962296, 22210890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AraC/XylS family) of synthesis and uptake of the siderophore bacillibactin" /protein_id="NP_388045.1" /db_xref="EnsemblGenomes-Gn:BSU01640" /db_xref="EnsemblGenomes-Tr:CAB11940" /db_xref="GOA:P40408" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG10834" /db_xref="UniProtKB/Swiss-Prot:P40408" /translation="MQNAVIYQPVQIEYLKKTSDLFSEQQLADSFVLIFHLKGNGYIS IGTNTNPLQKKTLYVCPPNETFGFTPAADGHIDACIIRLLSYIKETGQDIFTPCTESE LAKLKLMNVSHIENLAVRLQELAALWNESSQLSQLKCVIEVQSLIYDLFTASLSDQTD THSAIEKTKHYIETHADTKITLAQLSQMAGISAKHYSESFKKWTGQSVTEFITKTRIT KAKRLMAKSNCKLKEIAHQTGYQDEFYFSRIFKKYTGCSPTSYMKKRRKKIAAYGRGT MGHLIPLHHIPFAAALHPKWTSYYYQHYSTDIPVQLSAYRFNEKWEENLYTLSQAEPD VIVSMDSISPEEQDRLNRIAEVMYLPSEESWRTHFLQTASFLKEESEAEKWLADYDQQ TTAAKKTLQHVQGLRFLFLRLHKQNFYLAHNRSVREVFFGDLGFSSATTADTPSEQAI SLENIANYQADCMMLFLFKEPETIAYYQQLQQTEAWQNLSAVRDNRVYLLSLDPWNEY SACGHERIVQQTVSLLSGDCP*" /label="btr CDS" gene complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /label="btr gene" promotor_-10 complement(184643..184662) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(184655) /Source="Nicolas_upshifts" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(184677..184684) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(184764) /Source="Nicolas_upshifts" /id="D59" /incds=0 /nref=19 /ntot=58 /MaxReadThrough="1.28464" /MaxDrop="7.13916" /score="9.64466628" /energy="-10.1" /TU="NA" /idTUdmin="U116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388046.1" /db_xref="EnsemblGenomes-Gn:BSU01650" /db_xref="EnsemblGenomes-Tr:CAB11941" /db_xref="InterPro:IPR008302" /db_xref="SubtiList:BG10833" /db_xref="UniProtKB/Swiss-Prot:P40407" /translation="MRKTIFAFLTGLMMFGTITAASASPDSKNQTAKKPKVQTGIDTL LPDYKKQLKGKRIGLITNPAGVNTSLKSSVDILYENPDIKLTALFGPEHGVRGDAQAG DEVGSYIDEKTGVPVYSLYGKTKKPTPEMLKNVDILMFDIQDVGTRFYTYIYTMAYAM EAAKENGIPFMVLDRPNPQGGNHIEGPILEPEYASFVGLYPIPLKHGMTIGELASLFN KEFSIDADLTVVKMKHWKRKMDFDDTRLPFVLPSPNMPTVESTFVYPATGLIEGTNIS EGRGTTKPFELIGAPFIKSTELEETLNSLHLPGVTFRAASFTPTFSKHQGTLCHGVQL YVTDRDKFEAVKTGLSVIKTIHDLYPEDFEFLSTGSFDKLAGNGWIRTKIENGTSVEN IINSYEKTLQQFSKTRKKYLIY*" /label="ybbC CDS" gene complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /label="ybbC gene" downshifts complement(184814) /Source="Nicolas_upshifts" /id="D60" /incds=0 /nref=11 /ntot=122 /MaxReadThrough="7.66074" /MaxDrop="4.10379" /score="9.64466628" /energy="-10.1" /TU="U116" /idTUdmin="U116" /TUdmin="-50" /isTUend="FALSE" /label="downshifts" CDS complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /EC_number="3.2.1.52" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8063094, 20400549, 20826810, 23177201, 26963691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8063094, 20400549, 20826810, 23177201, 26963691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosaminidase lipoprotein" /protein_id="NP_388047.1" /db_xref="EnsemblGenomes-Gn:BSU01660" /db_xref="EnsemblGenomes-Tr:CAB11942" /db_xref="GOA:P40406" /db_xref="InterPro:IPR001764" /db_xref="InterPro:IPR002772" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR019800" /db_xref="InterPro:IPR036881" /db_xref="InterPro:IPR036962" /db_xref="PDB:3BMX" /db_xref="PDB:3LK6" /db_xref="PDB:3NVD" /db_xref="PDB:4GYJ" /db_xref="PDB:4GYK" /db_xref="SubtiList:BG10832" /db_xref="UniProtKB/Swiss-Prot:P40406" /translation="MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSL DEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQT VQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSII GKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIAS ALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAF DDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEA VVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISL KIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPK KGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEAD YIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPY DAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPG NTLYPLGYGLNIKTGRPL*" /label="nagZ CDS" gene complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /label="nagZ gene" CDS complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16452451, 20400549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16452451, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidase hydrolyzing N-acetylmuramyl-L-Ala bond of MurNAc peptides" /protein_id="NP_388048.2" /db_xref="EnsemblGenomes-Gn:BSU01670" /db_xref="EnsemblGenomes-Tr:CAB11943" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR022849" /db_xref="SubtiList:BG11566" /db_xref="UniProtKB/Swiss-Prot:O05213" /translation="MKTKTLFIFSAILTLSIFAPNETFAQTAGNLIEPKIINAETAQF STKKLRKVDQMIERDIAAGFPGAVLVVVKDGRIIKKAAYGYSKKYEGSELLRRPAKMK TRTMFDLASNTKMYATNFALQRLVSQGKLDVYEKVSAYLPGFKDQPGDLIKGKDKIRV IDVLQHQSGLPSSFYFYTPEKAGKYYSQERDKTIEYLTKIPLDYQTGTKHVYSDIGYM LLGCIVEKLTGKPLDVYTEQELYKPLRLKHTLYNPLQKGFKPKQFAATERMGNTRDGV IQFPNIRTNTLQGEVHDEKAFYSMDGVSGHAGLFSNADDMAILLQVMLNKGSYRNISL FDQKTADLFTAPSATDPTFALGWRRNGSKSMEWMFGPHASENAYGHTGWTGTVTIIDP AYNLGIALLTNKKHTPVIDPEENPNVFEGDQFPTGSYGSVITAIYEAME*" /label="amiE CDS" gene complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /label="amiE gene" CDS complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /EC_number="2.7.1.192" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060041, 15849754, 16850406, 10627040, 20400549, 22960854; Product type t : transporter" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid PTS permease-MurP subunit" /protein_id="NP_388049.3" /db_xref="EnsemblGenomes-Gn:BSU01680" /db_xref="EnsemblGenomes-Tr:CAB11944" /db_xref="GOA:Q797S1" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11567" /db_xref="UniProtKB/Swiss-Prot:Q797S1" /translation="MSKENNYHHLAQKILELCGGKSNISSYTHCMTRLRITPYDESKA DAQALRKLDGVLGVVEAETLQIILGTGVVNHVTAAFSKLVSAEEGADVKEAAAKKKAD INRKNATPFKLFLRKIASIFIPLIPALVASGLITGITKAIIQAGWLSADSQIAIILTV IGSGLFTYLGILVGINASKEFGGTPALGALAGILIINPEIAKISLFGEELLPGRGGLI GVLFAAIFIAYTEQFIRRFIPQSLDIIVTPTVSLLITGIVTYVVFMPLGGFISDAITS GLLSILDIGGIAAGFILGATFLPLVVTGLHQGLTPVHMELINSIGNDPLLPILAMGGA GQVGAAFAVFVKTKKTTLRKAIAGGLPSGLLGIGEPLIFGVTLPLGRPFLTACLGAGI GGAFQAYFQVATIAIGVSGLPLSFLVLPSQIILYIVGLFISYAAGFLLTYAFGYKDEM ASQFD*" /label="murP CDS" gene complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /label="murP gene" CDS complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20400549; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator MurR-N-acetylmuramic acid" /protein_id="NP_388050.1" /db_xref="EnsemblGenomes-Gn:BSU01690" /db_xref="EnsemblGenomes-Tr:CAB11945" /db_xref="GOA:Q45581" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="PDB:2O3F" /db_xref="SubtiList:BG11569" /db_xref="UniProtKB/Swiss-Prot:Q45581" /translation="MATGGLAIIQSMKHKLPPSERKLADYILAHPHKAIESTVNEISA LANSSDAAVIRLCKSLGLKGFQDLKMRVAGDLAKPTFQGYRDIVPHEPLPSISEKTAG NAIQAIQDTSDLMDYKELERAVSLLLKAHTVHFIGLGASGIVAKDAQQKWLRIHKQAT AFTDTHLVASLIANADKDDIVFAISFSGETQEIVELFAMAKEKGITTISLTQFSQTSV SALADVPLYTAHSNEALIRSAATSSRLAQLFIIDVLFLGMAAEQYETTTGYIDKTRAA IQSMRIK*" /label="murR CDS" gene complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /label="murR gene" CDS complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /EC_number="4.2.1.126" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15983044, 20400549, 16452451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lactyl ether N-acetylmuramic-6-phosphate acid etherase" /protein_id="NP_388051.1" /db_xref="EnsemblGenomes-Gn:BSU01700" /db_xref="EnsemblGenomes-Tr:CAB11946" /db_xref="GOA:Q45582" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005486" /db_xref="InterPro:IPR005488" /db_xref="SubtiList:BG11570" /db_xref="UniProtKB/Swiss-Prot:Q45582" /translation="MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAA VQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGI MAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARK VGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMV KIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLK TSTDQKQAQTLLDEANGFIDKAIEHYHP*" /label="murQ CDS" gene complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /label="murQ gene" promotor_-10 complement(192595..192613) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(192608) /Source="Nicolas_upshifts" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(192629..192636) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_388052.2" /db_xref="EnsemblGenomes-Gn:BSU01710" /db_xref="EnsemblGenomes-Tr:CAB11947" /db_xref="GOA:Q45583" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11571" /db_xref="UniProtKB/Swiss-Prot:Q45583" /translation="MTQDISLSFYKPEHLPELQSFTLTNDDKRFTSLPKEVLSQALGI QDRYPVVILKDDLPVGFFILHASKETLASYSNNPFALLLSSLSLTAVHHGKGYAKKAM LLLPAFVSGYFPWCDEIILAVNHLNIRAKHLYMKSGFLDKGRRRIGPLGEQLILHHFL *" /label="ybbJ CDS" gene complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /label="ybbJ gene" CDS complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388053.2" /db_xref="EnsemblGenomes-Gn:BSU01720" /db_xref="EnsemblGenomes-Tr:CAB11948" /db_xref="InterPro:IPR007553" /db_xref="SubtiList:BG11572" /db_xref="UniProtKB/Swiss-Prot:Q45584" /translation="MILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGG FSTPREPAEIIGGTGEDVLNGTAKIVTASGEDVTELYMEGAAKTLAYAKEINASAVIL KENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENELNDIL*" /label="ybbK CDS" gene complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /label="ybbK gene" promotor_-10 complement(193650..193669) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(193671) /Source="Nicolas_upshifts" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(193684..193685) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 193744..193751 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" promotor_-10 193766..193785 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" upshifts 193777 /Source="Nicolas_upshifts" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" tRNA 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu2 tRNA" gene 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /label="trnSL-Glu2 gene" tRNA 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val1 tRNA" gene 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /label="trnSL-Val1 gene" tRNA 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Thr1 tRNA" gene 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /label="trnSL-Thr1 gene" tRNA 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Tyr1 tRNA" gene 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /label="trnSL-Tyr1 gene" tRNA 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gln2 tRNA" gene 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /label="trnSL-Gln2 gene" downshifts 194223 /Source="Nicolas_upshifts" /id="D61" /incds=0 /nref=10 /ntot=91 /MaxReadThrough="4.25215" /MaxDrop="3.84626" /score="25.5087424" /energy="-11.4" /TU="U118" /idTUdmin="U118" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 194268..194385 /Source="Nicolas_S_feature" /locus_tag="new_194669_194786" /HighExp="Paraq, BMM, H2O2, Heat, G180, G135, Oxctl, G150, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S67" promotor_-35 194386..194395 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" upshifts 194387 /Source="Nicolas_upshifts" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" promotor_-10 194407..194422 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" CDS 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11866510, 15130127, 16629676, 21542858, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11866510, 15130127, 16629676, 21542858, 28319136, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor W" /protein_id="NP_388054.1" /db_xref="EnsemblGenomes-Gn:BSU01730" /db_xref="EnsemblGenomes-Tr:CAB11949" /db_xref="GOA:Q45585" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014294" /db_xref="InterPro:IPR036388" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11573" /db_xref="UniProtKB/Swiss-Prot:Q45585" /translation="MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHE AEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTE GLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGE ILNIPVGTVKTRIHRGREALRKQLRDL*" /label="sigW CDS" gene 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /label="sigW gene" CDS 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15130127, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 28319136, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(W) factor" /protein_id="NP_388055.1" /db_xref="EnsemblGenomes-Gn:BSU01740" /db_xref="EnsemblGenomes-Tr:CAB11950" /db_xref="GOA:Q45588" /db_xref="InterPro:IPR027383" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11574" /db_xref="UniProtKB/Swiss-Prot:Q45588" /translation="MSCPEQIVQLMHMHLDGDILPKDEHVLNEHLETCEKCRKHFYEM EKSIALVRSTSHVEAPADFTANVMAKLPKEKKRASVKRWFRTHPVIAAAAVFIILMGG GFFNSWHNDHNFSVSKQPNLVVHNHTVTVPEGETVKGDVTVKNGKLIIKGKIDGDVTV VNGEKYMASAGQVTGQIEEINQLFDWTWYKMKSAGKSVLDAFNPNGEE*" /label="rsiW CDS" gene 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /label="rsiW gene" downshifts complement(195443) /Source="Nicolas_upshifts" /id="D62" /incds=1 /nref=2 /ntot=181 /MaxReadThrough="1.52124" /MaxDrop="3.24828" /score="0.305471631" /energy="-6.9" /TU="NA" /idTUdmin="U120" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(195601..195701) /Source="Nicolas_upshift_promotors" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts 195631 /Source="Nicolas_upshifts" /id="D63" /incds=0 /nref=251 /ntot=269 /MaxReadThrough="4.26924" /MaxDrop="8.34597" /score="7.39786279" /energy="-10.8" /TU="U119" /idTUdmin="U119" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" upshifts complement(195641) /Source="Nicolas_upshifts" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 195700..195707 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-35" promotor_-10 195722..195741 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-10" S_feature 195731..195811 /Source="Nicolas_S_feature" /locus_tag="new_196132_196212" /HighExp="dia5, Diami, H2O2, dia15, G135, Cold, G180, Paraq, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA" /TUlongPSig="1, 1" /label="S68" upshifts 195731 /Source="Nicolas_upshifts" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="upshifts" CDS 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /EC_number="2.7.7.85" /function="16.13: Shape" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase" /protein_id="NP_388056.2" /db_xref="EnsemblGenomes-Gn:BSU01750" /db_xref="EnsemblGenomes-Tr:CAB11951" /db_xref="GOA:Q45589" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR034701" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG11577" /db_xref="UniProtKB/Swiss-Prot:Q45589" /translation="MAFEDIPFLQYLGNAVDILLVWYVIYKLIMVIRGTKAVQLLKGI VVIVLVRMASQYLGLSTLQWLMDQAITWGFLAIIIIFQPELRRALEQLGRGRFFSRSG TPVEEAQQKTIEAITKAINYMAKRRIGALLTIERDTGMGDYIETGIPLNAKVSSELLI NIFIPNTPLHDGAVIMKNNEIAAAACYLPLSESPFISKELGTRHRAAVGISEVTDSLT IIVSEETGGVSVAKNGDLHRELTEEALKEMLEAEFKKNTRDTSSNRWYWRGKKNG*" /label="cdaA CDS" gene 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /label="cdaA gene" CDS 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /experiment="publication(s) with functional evidences, PMID:16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of diadenylate cyclase activity" /protein_id="NP_388057.2" /db_xref="EnsemblGenomes-Gn:BSU01760" /db_xref="EnsemblGenomes-Tr:CAB11952" /db_xref="GOA:O34659" /db_xref="InterPro:IPR012505" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12703" /db_xref="UniProtKB/Swiss-Prot:O34659" /translation="MDKFLNNRWAVKIIALLFALLLYVAVNSNQAPTPKKPGESFFPT STTDEATLTDIPVKAYYDDENYVVTGVPQTVNVTIKGSTSAVKKARQTKNFEIYADME HLKTGTHKVELKAKNVSDGLTISINPSVTTVTIQERTTKSFPVEVEYYNKSKMKKGYS PEQPIVSPKNVQITGSKNVIDNISLVKASVNLENADETIEKEAKVTVYDKDGNALPVD VEPSVIKITVPVTSPSKKVPFKIERTGSLPDGVSIANIESSPSEVTVYGSQDVLDSLE FIDGVSLDLSKINKDSDIEADIPLPDGVKKISPSKVTLHIEVDSEADQKFENVPIKTV GLSSSQNIEFLDPESQAIDVTAKGSPTNINKLKKSDIELYVNVSDLEDGEHSVKLEVN GPQNVTWSLGRKNAKIKLTSKKSNTSTNDNSSNTSGNQDTDKQTNDQKNNQQEDTKNT DKNNNDQNQDGNKDQNQDQDEDESTANSQSSSE*" /label="cdaR CDS" gene 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /label="cdaR gene" CDS 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /EC_number="5.4.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10671448, 10913078, 12089032, 21154411, 26240071, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671448, 10913078, 12089032, 21154411, 26240071, 27074767; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoglucosamine mutase" /protein_id="NP_388058.1" /db_xref="EnsemblGenomes-Gn:BSU01770" /db_xref="EnsemblGenomes-Tr:CAB11953" /db_xref="GOA:O34824" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR006352" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG12704" /db_xref="UniProtKB/Swiss-Prot:O34824" /translation="MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVL IGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHN PVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYL QFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGS THPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLK DDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLD YNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKA VISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE*" /label="glmM CDS" gene 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /label="glmM gene" downshifts 199437 /Source="Nicolas_upshifts" /id="D64" /incds=0 /nref=126 /ntot=216 /MaxReadThrough="5.32721" /MaxDrop="5.02497" /score="13.5044076" /energy="-17.5" /TU="U121" /idTUdmin="U121" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 199461..199469 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 199477 /Source="Nicolas_upshifts" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 199483..199502 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 199529..199534 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 199550..199569 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 199556 /Source="Nicolas_upshifts" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_feature 199600..199616 /Source="Nicolas_upshift_promotors" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 199613 /Source="Nicolas_upshifts" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /product="riboswitch and ribozyme (GlmS-glucosamine-6-P)" /experiment="publication(s) with functional evidences, PMID:16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261; Product type n: RNA" /label="glmSA RNA" gene 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /label="glmSA gene" S_feature 199787..199875 /Source="Nicolas_S_feature" /locus_tag="new_200188_200276" /HighExp="M40t90, M0t90, M9-stat, Lbstat, T2.30H, T2.0H, T3.0H, T1.30H, T1.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.498, 0.999, 0.754" /TUlongSig="SigA, SigWXY, SigA" /TUlongPSig="1, 1, 1" /label="S69" CDS 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /EC_number="2.6.1.16" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15029187, 17114942, 17283212, 17322533, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine-D-fructose-6-phosphate amidotransferase" /protein_id="NP_388059.1" /db_xref="EnsemblGenomes-Gn:BSU01780" /db_xref="EnsemblGenomes-Tr:CAB11954" /db_xref="GOA:P0CI73" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005855" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR035466" /db_xref="InterPro:IPR035490" /db_xref="SubtiList:BG10948" /db_xref="UniProtKB/Swiss-Prot:P0CI73" /translation="MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEQGIHV FKEKGRIADLREVVDANVEAKAGIGHTRWATHGEPSYLNAHPHQSALGRFTLVHNGVI ENYVQLKQEYLQDVELKSDTDTEVVVQVIEQFVNGGLETEEAFRKTLTLLKGSYAIAL FDNDNRETIFVAKNKSPLLVGLGDTFNVVASDAMAMLQVTNEYVELMDKEMVIVTDDQ VVIKNLDGDVITRASYIAELDASDIEKGTYPHYMLKETDEQPVVMRKIIQTYQDENGK LSVPGDIAAAVAEADRIYIIGCGTSYHAGLVGKQYIEMWANVPVEVHVASEFSYNMPL LSKKPLFIFLSQSGETADSRAVLVQVKALGHKALTITNVPGSTLSREADYTLLLHAGP EIAVASTKAYTAQIAVLAVLASVAADKNGINIGFDLVKELGIAANAMEALCDQKDEME MIAREYLTVSRNAFFIGRGLDYFVCVEGALKLKEISYIQAEGFAGGELKHGTIALIEQ GTPVFALATQEHVNLSIRGNVKEVAARGANTCIISLKGLDDADDRFVLPEVNPALAPL VSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE*" /label="glmS CDS" gene 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /label="glmS gene" S_feature complement(201401..>201681) /Source="Nicolas_S_feature" /locus_tag="new_201802_202546_c" /HighExp="S8, S7, S6, S5, S4, BC, S3, Sw, C30, LoTm" /AntisenseName="glmS" /AntisenseCor="4.5056549205256403E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S70" downshifts 201664 /Source="Nicolas_upshifts" /id="D65" /incds=0 /nref=260 /ntot=277 /MaxReadThrough="3.18134" /MaxDrop="7.61794" /score="13.5044076" /energy="-17.5" /TU="NA" /idTUdmin="U122" /TUdmin=2 /isTUend="TRUE" /label="downshifts" SCAR join(201681,201727) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta4" N_region 201682..201726 /note="insertion of 45 bases of unknown origin" /modified_by="User" /label="Delta4" S_feature <201727..201845 /Source="Nicolas_S_feature" /locus_tag="new_220105_220278" /HighExp="LoTm, T5.0H, T4.0H, T3.30H, Pyr, T-2.40H, T3.0H, T-5.40H, S2, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S79" CDS 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase/transferase" /protein_id="NP_388081.2" /db_xref="EnsemblGenomes-Gn:BSU01990" /db_xref="EnsemblGenomes-Tr:CAB11993" /db_xref="GOA:O31431" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12722" /db_xref="UniProtKB/Swiss-Prot:O31431" /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGK GTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAG YGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKA IIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDE EKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKY AIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR*" /label="ybdG CDS" gene 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /label="ybdG gene" CDS 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component system response regulator [YbdK]" /protein_id="NP_388082.1" /db_xref="EnsemblGenomes-Gn:BSU02000" /db_xref="EnsemblGenomes-Tr:CAB11994" /db_xref="GOA:O31432" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12723" /db_xref="UniProtKB/Swiss-Prot:O31432" /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQ KVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKP FDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYL YENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLN TVVKK*" /label="ybdJ CDS" gene 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /label="ybdJ gene" promotor_-35 203390..203396 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 203410..203429 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 203428 /Source="Nicolas_upshifts" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component system sensor histidine kinase [YbdJ]" /protein_id="NP_388083.1" /db_xref="EnsemblGenomes-Gn:BSU02010" /db_xref="EnsemblGenomes-Tr:CAB11995" /db_xref="GOA:O31433" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12724" /db_xref="UniProtKB/Swiss-Prot:O31433" /translation="MLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMPFHRSFAY PAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVKRADEIG ELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLEDQCHG QAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDYLYSM SGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIRDDG IGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE*" /label="ybdK CDS" gene 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /label="ybdK gene" promotor_-35 204491..204493 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 204509..204528 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 204512 /Source="Nicolas_upshifts" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097672.1" /db_xref="EnsemblGenomes-Gn:BSU02019" /db_xref="EnsemblGenomes-Tr:CAX52542" /db_xref="UniProtKB/Swiss-Prot:C0H3T1" /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAV RAKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD*" /label="ybzI CDS" gene 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /label="ybzI gene" downshifts 204742 /Source="Nicolas_upshifts" /id="D73" /incds=0 /nref=120 /ntot=235 /MaxReadThrough="2.82444" /MaxDrop="4.652" /score="22.3698707" /energy="-12.1" /TU="U135" /idTUdmin="U136" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /EC_number="2.7.11.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21304896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein kinase" /protein_id="NP_388085.1" /db_xref="EnsemblGenomes-Gn:BSU02030" /db_xref="EnsemblGenomes-Tr:CAB11997" /db_xref="GOA:O31435" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG12726" /db_xref="UniProtKB/Swiss-Prot:O31435" /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTD ILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVM QFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDG RLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEEL TLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT*" /label="ybdM CDS" gene complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /label="ybdM gene" CDS complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16794953; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388086.1" /db_xref="EnsemblGenomes-Gn:BSU02040" /db_xref="EnsemblGenomes-Tr:CAB11998" /db_xref="SubtiList:BG12727" /db_xref="UniProtKB/Swiss-Prot:O31436" /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIG YWKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQ GTEVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQ FSGVAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHL IMTSENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKID YEYDVTKQF*" /label="ybdN CDS" gene complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /label="ybdN gene" downshifts complement(205664) /Source="Nicolas_upshifts" /id="D74" /incds=0 /nref=95 /ntot=184 /MaxReadThrough="1.56932" /MaxDrop="4.95806" /score="36.4950689" /energy="-11.9" /TU="NA" /idTUdmin="U137" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(205713..205732) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(205746..205755) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(205748) /Source="Nicolas_upshifts" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(206512..206531) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(206537) /Source="Nicolas_upshifts" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(206546..206553) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 206567..206574 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-35" promotor_-10 206588..206606 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-10" upshifts 206590 /Source="Nicolas_upshifts" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="upshifts" CDS 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388087.1" /db_xref="EnsemblGenomes-Gn:BSU02050" /db_xref="EnsemblGenomes-Tr:CAB11999" /db_xref="InterPro:IPR032617" /db_xref="SubtiList:BG12728" /db_xref="UniProtKB/Swiss-Prot:O31437" /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRL KSQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESD IRIKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEW LFKGKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTE LTFTITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEA YKKYQAAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAI SYYRSELSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGV NY*" /label="ybdO CDS" gene 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /label="ybdO gene" downshifts 207801 /Source="Nicolas_upshifts" /id="D75" /incds=0 /nref=107 /ntot=207 /MaxReadThrough="2.98334" /MaxDrop="4.9582" /score="-3.87053033" /energy="-8.3" /TU="U139" /idTUdmin="U139" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" promotor_-35 207969..207975 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 207989..208008 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 208003..208132 /Source="Nicolas_S_feature" /locus_tag="new_226436_226565" /HighExp="Glu, LoTm, M9-stat, G135, GM-0.2, T-0.40H, Fru, UNK1, MG 120, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD" /TUlongPSig=1 /label="S80" upshifts 208003 /Source="Nicolas_upshifts" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="upshifts" CDS 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388088.1" /db_xref="EnsemblGenomes-Gn:BSU02060" /db_xref="EnsemblGenomes-Tr:CAB12000" /db_xref="GOA:P54425" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11505" /db_xref="UniProtKB/Swiss-Prot:P54425" /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVL LAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVG MSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTII LMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIG ITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKI GITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGT IAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKH PFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRT QANLTKSEQAAE*" /label="ybxG CDS" gene 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /label="ybxG gene" downshifts 209529 /Source="Nicolas_upshifts" /id="D76" /incds=0 /nref=121 /ntot=219 /MaxReadThrough="2.32902" /MaxDrop="5.72049" /score="28.6554212" /energy="-8.5" /TU="NA" /idTUdmin="U140" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" promotor_-35 209567..209573 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 209587..209598 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 209588 /Source="Nicolas_upshifts" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="upshifts" CDS 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9016963" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9016963; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific SASP protein" /protein_id="NP_388089.1" /db_xref="EnsemblGenomes-Gn:BSU02070" /db_xref="EnsemblGenomes-Tr:CAB12001" /db_xref="GOA:P54379" /db_xref="InterPro:IPR020255" /db_xref="SubtiList:BG11504" /db_xref="UniProtKB/Swiss-Prot:P54379" /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYANEEEFVKDLD DNEMSFLNHVLEKEIKYAQNEQDQKRAKELNEVYELLL*" /label="csgA CDS" gene 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /label="csgA gene" CDS 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388090.1" /db_xref="EnsemblGenomes-Gn:BSU02080" /db_xref="EnsemblGenomes-Tr:CAB12002" /db_xref="InterPro:IPR035314" /db_xref="SubtiList:BG11506" /db_xref="UniProtKB/Swiss-Prot:P54426" /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEY PDHDLIEELVNHYCFEHEI*" /label="ybxH CDS" gene 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /label="ybxH gene" downshifts 210071 /Source="Nicolas_upshifts" /id="D77" /incds=0 /nref=17 /ntot=40 /MaxReadThrough="0.194030000000001" /MaxDrop="4.779" /score="29.4617878" /energy="-15.6" /TU="NA" /idTUdmin="U141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /EC_number="3.5.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14742199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14742199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported beta-lactamase" /protein_id="NP_388091.1" /db_xref="EnsemblGenomes-Gn:BSU02090" /db_xref="EnsemblGenomes-Tr:CAB12003" /db_xref="GOA:P54427" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR002137" /db_xref="InterPro:IPR012338" /db_xref="PDB:5E2F" /db_xref="SubtiList:BG11507" /db_xref="UniProtKB/Swiss-Prot:P54427" /translation="MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFK DTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWD GVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGID QFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTGTR LTDMGLGWFVGFIKTEHGSYVFVTNVDDSGTKAKNITVDILKKYGLITS*" /label="ybxI CDS" gene complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /label="ybxI gene" promotor_-10 complement(210941..210959) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(210949) /Source="Nicolas_upshifts" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(210970..210978) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 211033..211039 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 211054..211072 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 211060 /Source="Nicolas_upshifts" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="upshifts" CDS 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /EC_number="1.11.2.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10529095, 12519760, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10529095, 12519760, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid beta-hydroxylating cytochrome P450" /protein_id="NP_388092.1" /db_xref="EnsemblGenomes-Gn:BSU02100" /db_xref="EnsemblGenomes-Tr:CAB12004" /db_xref="GOA:O31440" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR036396" /db_xref="PDB:1IZO" /db_xref="PDB:2ZQJ" /db_xref="PDB:2ZQX" /db_xref="SubtiList:BG12729" /db_xref="UniProtKB/Swiss-Prot:O31440" /translation="MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS LHYSLARMPSLPESGFVMSGIRRKS*" /label="cypC CDS" gene 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /label="cypC gene" misc_feature 211404..211411 /Source="Nicolas_upshift_promotors" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 211414 /Source="Nicolas_upshifts" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 212338 /Source="Nicolas_upshifts" /id="D78" /incds=0 /nref=5 /ntot=36 /MaxReadThrough="2.65245" /MaxDrop="6.12325" /score="-7.42298703" /energy="-14.7" /TU="NA" /idTUdmin="U143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388093.1" /db_xref="EnsemblGenomes-Gn:BSU02110" /db_xref="EnsemblGenomes-Tr:CAB12005" /db_xref="SubtiList:BG12754" /db_xref="UniProtKB/Swiss-Prot:O31441" /translation="MKQKLLLSGLAVSTVGITSYLLKDPSNRQKAREFIHSMKMKITK QPDMETFPVDKAGHPDPQDIEDNKMVSEGSMYPVQYYDEKKK*" /label="ybyB CDS" gene complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /label="ybyB gene" downshifts complement(212405) /Source="Nicolas_upshifts" /id="D79" /incds=0 /nref=155 /ntot=247 /MaxReadThrough="3.63752" /MaxDrop="7.83539" /score="8.86703843" /energy="-12.4" /TU="U145" /idTUdmin="U145" /TUdmin="-387" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(212676..212694) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(212685) /Source="Nicolas_upshifts" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(212708..212714) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 212838..212845 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 212855 /Source="Nicolas_upshifts" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 212861..212880 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/amino acid transporter" /protein_id="NP_388094.2" /db_xref="EnsemblGenomes-Gn:BSU02120" /db_xref="EnsemblGenomes-Tr:CAB12006" /db_xref="GOA:Q45577" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12730" /db_xref="UniProtKB/Swiss-Prot:Q45577" /translation="MNQLHRRMGTFSLMMVGLGSMIGSGWLFGAWRAAQIAGPAAIIS WVIGMVVILFIALSYSELGSMFPEAGGMVKYTQYSHGSFIGFIAGWANWIAIVSVIPV EAVASVQYMSSWPWEWAKWTSGLVKNGTLTGEGLAFASVLLLIYFLLNYWTVNLFSKA NSLITIFKIIIPGLTIGALLFVGFHGENFTGGQSIAPNGWASVLTAVATSGIVFAFNG FQSPINMAGEAKNPGKSIPIAVVGSLFVATVIYVLLQIAFIGAVNPSDIAHGWSHLNF NSPFADLAIALNINWLVIVLYADAFVSPSGTGITYTATTSRMIYGMEKNKYMPSIFGK LHPIYGVPRQAMFFNLIVSFIFLFLFRGWGVLAEIISVATLISYITGPITVMTLRRTG KDLYRPLRLKGLNVIAPLGFIFASLVLYWARWPLTGQVLFIILIGLPIYFYYQAKAKW KGFGRNFKAGVWMVFYLLAMMVISYLGSDKFGGLNVIHYGWDMVLIAMVSLVFYVWAL KSGYQTEYLKDAKEINSQLLNGQSEAAAGKE*" /label="ybeC CDS" gene 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /label="ybeC gene" downshifts 214517 /Source="Nicolas_upshifts" /id="D80" /incds=0 /nref=183 /ntot=273 /MaxReadThrough="0.8051" /MaxDrop="6.79949" /score="24.7668372" /energy="-12.2" /TU="NA" /idTUdmin="U146" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10913081, 21966272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 21966272; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted glycerophosphoryl diester phosphodiesterase" /protein_id="NP_388095.1" /db_xref="EnsemblGenomes-Gn:BSU02130" /db_xref="EnsemblGenomes-Tr:CAB12007" /db_xref="GOA:P37965" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="PDB:5T91" /db_xref="PDB:5T9B" /db_xref="PDB:5T9C" /db_xref="SubtiList:BG10646" /db_xref="UniProtKB/Swiss-Prot:P37965" /translation="MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHR GASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDH TLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYP GMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMAS MTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVT GVFTNYPDLFHKVKKGY*" /label="glpQA CDS" gene complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /label="glpQA gene" downshifts complement(214592) /Source="Nicolas_upshifts" /id="D81" /incds=0 /nref=61 /ntot=107 /MaxReadThrough="2.31368" /MaxDrop="7.76277" /score="9.56390732" /energy="-11.4" /TU="NA" /idTUdmin="U147" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(215505) /Source="Nicolas_upshifts" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(215514..215530) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(215539..215545) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8012593, 11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012593, 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate permease" /protein_id="NP_388096.1" /db_xref="EnsemblGenomes-Gn:BSU02140" /db_xref="EnsemblGenomes-Tr:CAB12008" /db_xref="GOA:P37948" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR005267" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR021159" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10645" /db_xref="UniProtKB/Swiss-Prot:P37948" /translation="MLNIFKPAPHIERLDDSKMDAAYKRLRLQVFIGIFIGYAGYYLL RKNFAFAIPYLQEQGFSKTELGLVLAAVSIAYGFSKFIMGMVSDRCNPRYFLATGLFL SAIVNILFVSMPWVTSSVTIMFIFMFINGWFQGMGWPPCGRTMAHWFSISERGTKMSI WNVAHNIGGGILAPLVTLGIAMFVTWKSVFFFPAIIAIIISFLIVLLVRDTPQSCGLP PIEEYRNDYPKHAFKNQEKELTTKEILFQYVLNNKFLWYIAFANVFVYFVRYGVVDWA PTYLTEAKGFSPEDSRWSYFLYEYAGIPGTILCGWISDRFFKSRRAPAGVLFMAGVFI AVLVYWLNPAGNPLVDNIALISIGFLIYGPVMLIGLQAIDLAPKKAAGTAAGLTGFFG YIGGSAFANAIMGFVVDRFNWNGGFIMLISSCILAIVFLALTWNTGKRAEHV*" /label="glpT CDS" gene complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /label="glpT gene" promotor_-35 216543..216552 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 216565..217191 /Source="Nicolas_S_feature" /locus_tag="new_234998_235624" /HighExp="S6, S8, S7, S5, BT, B36, G/S, C30, Pyr, B60" /AntisenseName="glpT" /AntisenseCor="-5.0958691169636701E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S81" promotor_-10 216565..216584 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 216565 /Source="Nicolas_upshifts" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216896..216968) /Source="Nicolas_S_feature" /locus_tag="new_235329_235401_c" /HighExp="G150, Oxctl, Paraq, S0, Diami, H2O2, Lbexp, dia5, dia0, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.042, 0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S82" promotor_no_box complement(216928..217028) /Source="Nicolas_upshift_promotors" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(216968) /Source="Nicolas_upshifts" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216970..217056) /Source="Nicolas_S_feature" /locus_tag="new_235403_235489_c" /HighExp="G150, Oxctl, S0, Diami, Lbexp, dia5, Paraq, dia0, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S83" promotor_-10 complement(217046..217065) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(217060) /Source="Nicolas_upshifts" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(217078..217085) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388097.1" /db_xref="EnsemblGenomes-Gn:BSU02150" /db_xref="EnsemblGenomes-Tr:CAB12009" /db_xref="GOA:O31442" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG12731" /db_xref="UniProtKB/Swiss-Prot:O31442" /translation="MDELDIAFFILPLGIMLLSIVGTCICKNPYLMPMLSLVISLVLT FTIFNQSFLGWAVVYSLVSLALSYITLIVVRKRKESGN*" /label="ybeF CDS" gene 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /label="ybeF gene" promotor_-35 217464..217471 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 217471 /Source="Nicolas_upshifts" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 217487..217506 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator with acetyltransferase domain" /protein_id="NP_388098.1" /db_xref="EnsemblGenomes-Gn:BSU02160" /db_xref="EnsemblGenomes-Tr:CAB12010" /db_xref="GOA:O31443" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12732" /db_xref="UniProtKB/Swiss-Prot:O31443" /translation="MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILF EIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGK TIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFL SEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKH DEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKK FGFRISEVKQEAPLWGQQLTEERWDLELS*" /label="ybfA CDS" gene 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /label="ybfA gene" CDS 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carboxylate transporter" /protein_id="NP_388099.1" /db_xref="EnsemblGenomes-Gn:BSU02170" /db_xref="EnsemblGenomes-Tr:CAB12011" /db_xref="GOA:O31444" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12733" /db_xref="UniProtKB/Swiss-Prot:O31444" /translation="MKRLHYAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRS TISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFL LYGLGVSLGVGGASNVAASVLVVNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHW FSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASEKETAPKTTALSVA GMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAG ILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGLVDFATVAPT QMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAFYLSIGMLVL ASVMNVMLREPAAVTRDSAAVVDK*" /label="ybfB CDS" gene 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /label="ybfB gene" downshifts 219686 /Source="Nicolas_upshifts" /id="D82" /incds=0 /nref=57 /ntot=187 /MaxReadThrough="1.17226" /MaxDrop="5.55429" /score="12.1347284" /energy="-9.5" /TU="NA" /idTUdmin="U151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminal end)" /db_xref="EnsemblGenomes-Gn:BSU02180" /db_xref="EnsemblGenomes-Tr:CAB12012" /db_xref="GOA:O31445" /db_xref="PSEUDO:CAB12012.2" /db_xref="SubtiList:BG12734" /db_xref="UniProtKB/Swiss-Prot:O31445" /translation="MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFA LIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE*" /label="ybfEc CDS" gene complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /pseudo /label="ybfEc gene" downshifts complement(219784) /Source="Nicolas_upshifts" /id="D83" /incds=0 /nref=4 /ntot=189 /MaxReadThrough="2.49989" /MaxDrop="3.7302" /score="13.7144473" /energy="-12.6" /TU="U153" /idTUdmin="U153" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function YbfE (N-terminal fragment)" /db_xref="PSEUDO:SOX90538.1" /translation="MLNQLKVFFSEPLLTFKHTCQNRMYCDINNVILLFFQHSF*" /label="ybfEn CDS" gene complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /pseudo /label="ybfEn gene" S_feature complement(220016..220136) /Source="Nicolas_S_feature" /locus_tag="new_238449_238569_c" /HighExp="Lbexp, dia0, LBGexp, G150, Mt0, H2O2, dia5, M0t45, G135, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-" /TUshortPSig="0.899, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S84" promotor_-10 complement(220121..220139) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(220136) /Source="Nicolas_upshifts" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(220138..220210) /Source="Nicolas_S_feature" /locus_tag="new_238571_238643_c" /HighExp="Lbexp, dia0, LBGexp, HPh, G150, H2O2, dia5, Mt0, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S85" promotor_-35 complement(220156..220161) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388101.1" /db_xref="EnsemblGenomes-Gn:BSU02190" /db_xref="EnsemblGenomes-Tr:CAB12013" /db_xref="GOA:O31446" /db_xref="SubtiList:BG12735" /db_xref="UniProtKB/Swiss-Prot:O31446" /translation="MKNDQIVFEKTKNIAHDINQMQNQQEIIDYLFRQDSLTLNQLKH YYSEPSLPLQFLVKVAVLCMFISMTLASFLFIQAKEVFTNTILSDISPAVFSIFTVIC IFMTYTKIIKKGNKNKGKASLNQRSEFYEKNKLINTILYKKYKMDQQNIQANKHTASD NEDSMNFSAVLNHVLTISKNDKELLGYLDTRDNAMLSQLKAYFSTRPFSLPHYMSLMF CGSIIVVYATSLFSGQINYIDIPHIFIFLLLIIFLKILIDLIKLLNISRKGQLHTVLH FAQRAEYLRMRGVIDFILTERYNKKIM*" /label="ybfF CDS" gene complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /label="ybfF gene" S_feature complement(221123..221210) /Source="Nicolas_S_feature" /locus_tag="new_239556_239643_c" /HighExp="LBGexp, Lbexp, G150, dia5, dia0, G135, Oxctl, H2O2, Mt0, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S86" CDS complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pepdidoglycan binding protein" /protein_id="NP_388102.1" /db_xref="EnsemblGenomes-Gn:BSU02200" /db_xref="EnsemblGenomes-Tr:CAB12014" /db_xref="GOA:O31447" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG12736" /db_xref="UniProtKB/Swiss-Prot:O31447" /translation="MVDEMVLITQQWLNDTYSGKHGYNPVEESGKTGWDTIYGLTRAL QIELGISEPADNFGPTTQRLFKPLKRQAPDSKPSNMNFILQGALWCKGFNPGGFTGVF YEKTENAVKEFQKAAGLTTQDGIVTTLIMKALLDMSAFKLVSGGDSRIRQIQQNLNRD YNDYIGLMPCDGLYGRDTNKALIYALQKEEGMSTSVANGFFGNGTTSLCPTLTPGDSR TGFVLIVQYALYCNGKSFDPGEFDGKYGVGVVSAVKAFQEFMCLPQTGYADMPTIKAL LSSSGDTTRTASACDTATIITAEKAQTLRNNGYKTVGRYLTGNVRTSSGLTSKALTSK ELAVILDAGLKVFPIYQDGGYESSYFVKDQGTRDAYSAASAARRLGFPSGTTIYFAVD FDAYDYEVTDKIIPYFQEIKSAFTKMQTFSTAPKYEIGVYGPRNICIRTSEAGLTKYS FVANMSTGFSGNLGYPMPNNWAFDQFYEGTIGSGSGSIGIDKDGYSGRDSGASNVNPP SDPVYDARLRTLTDILSTIPALENLTSLANAMFEFDTTETIFTSPELDIILSTSLLAT IPSEGSPNTITITNGKPGAYITGLLGDTQTSLTASQIDSYQNLLNSLSLSVRNGYLEV YVNPTAESLNIQIKIYTPDIPVGDNVTTGLTTTITFKIKTYKGVPVTSPESELALDWP SYDQYLFPVVGVAALLLIGNMGSDLTNNKGVKVATALSAMLLAIFAYYTS*" /label="ybfG CDS" gene complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /label="ybfG gene" misc_feature complement(223444..223462) /Source="Nicolas_upshift_promotors" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(223456) /Source="Nicolas_upshifts" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388103.1" /db_xref="EnsemblGenomes-Gn:BSU02210" /db_xref="EnsemblGenomes-Tr:CAB12015" /db_xref="GOA:O31448" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12737" /db_xref="UniProtKB/Swiss-Prot:O31448" /translation="MNIQRETSGHIAAIVTILIWGTTFISTKVLLADFSPMEILFYRF LMGFIALILVRPNMIPFRNWRQELLFAGAGLFGVTLYFLLENIALTYTYASNVGMIVS IIPMITAVLAHFLLEGEKLRLTFLIGFISALIGLLLITFNGNVVLRLNPLGDIMAAGA ALVFGGYSIFMKKLSAYEYHIIELTQRVFLYGLLFMVPALFLFDFHFDLSRFSSASNI LNMLFLGIGASALCFATWNYSVGVLGAVKSSAYIYMVPVITIAASVLILHENMTWIAL LGGALTLLGLYISELKPKAKLLENGCKMDA*" /label="ybfH CDS" gene complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /label="ybfH gene" CDS complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family, cupin family)" /protein_id="NP_388104.1" /db_xref="EnsemblGenomes-Gn:BSU02220" /db_xref="EnsemblGenomes-Tr:CAB12016" /db_xref="GOA:O31449" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12738" /db_xref="UniProtKB/Swiss-Prot:O31449" /translation="MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKG QRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITG SGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFL SSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYME TIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR* " /label="ybfI CDS" gene complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /label="ybfI gene" misc_feature complement(225255..225274) /Source="Nicolas_upshift_promotors" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(225262) /Source="Nicolas_upshifts" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 225402..225405 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 225420..225439 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 225425 /Source="Nicolas_upshifts" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="upshifts" CDS 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /EC_number="2.1.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496533; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase 2" /protein_id="NP_388105.1" /db_xref="EnsemblGenomes-Gn:BSU02230" /db_xref="EnsemblGenomes-Tr:CAB12017" /db_xref="GOA:P39771" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005862" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10924" /db_xref="UniProtKB/Swiss-Prot:P39771" /translation="MYQSKKVLLLGSGELGKEVVIEAQRLGVQTVAVDSYEHAPAMQV AHNSYVVDMLDPEQIRTIIEKENPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKL TMDREGIRRLAAETLGLATAGYEFANTYDEFIQAAAQIGFPCVVKPLMSSSGKGQSVC RSEADLESCWETAMEGGRVKNGRVIVEEFIPFESEITLLTVRAVNGTAFCEPIGHVQK DGDYIESWQPHDMTEQQIEEAKHIAKTITDELGGYGLFGVELFLAKDRVYFSEVSPRP HDTGLVTLVTQNLSEFALHVRAILGFPITEITQLSPGASRPLKAPEELADYTVEGLEN ALAVPKTQVRVFGKPITKAGRRMAVALSAADSVETARENAKKALDQLILK*" /label="purT CDS" gene 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /label="purT gene" downshifts 226594 /Source="Nicolas_upshifts" /id="D84" /incds=0 /nref=100 /ntot=189 /MaxReadThrough="2.6996" /MaxDrop="5.22319" /score="39.2561117" /energy="-15.1" /TU="NA" /idTUdmin="U155" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 226633..226634 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_026" CDS 226647..227522 /gene="cesB" /locus_tag="PG10_pseudo_BSU02260" /old_locus_tag="BSU_02260" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11389736, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11389736, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enantioselective carboxylesterase" /protein_id="NP_388108.1" /db_xref="EnsemblGenomes-Gn:BSU02260" /db_xref="EnsemblGenomes-Tr:CAB12020" /db_xref="GOA:O31452" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:4CCY" /db_xref="SubtiList:BG12740" /db_xref="UniProtKB/Swiss-Prot:O31452" /modified_by="User" /translation="MQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKTHIIAS GPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAMETRADF AEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFISFHPDV YKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTENGFPYV FTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLSLEQPE YVNQRVLSFLCGGIK*" /label="PG10_pseudo_BSU02260" gene 226647..227522 /gene="cesB" /locus_tag="PG10_pseudo_BSU02260" /old_locus_tag="BSU_02260" /modified_by="User" /label="PG10_pseudo_BSU02260" promotor_-35 226866..226873 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 226882 /Source="Nicolas_upshifts" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 226887..226905 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 227523..227717 /Source="Nicolas_S_feature" /locus_tag="new_247549_247743" /HighExp="Cold, LBGstat, Paraq, Oxctl, H2O2, dia15, G135, Diami, Lbexp, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.867, 1" /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S88" CDS 227718..228251 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /EC_number="2.7.8.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 15743965, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 15743965, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine synthase" /protein_id="NP_388109.1" /db_xref="EnsemblGenomes-Gn:BSU02270" /db_xref="EnsemblGenomes-Tr:CAB12021" /db_xref="GOA:P39823" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004533" /db_xref="SubtiList:BG11012" /db_xref="UniProtKB/Swiss-Prot:P39823" /translation="MNYIPCMITIGNFICGLLAIHSLLYHNIHSAVLFIFTGMFLDFF DGMAARKLNAVSDMGRELDSFADLVTFGVAPSMLAYSVALYTLPFIGILCALTYSICG MLRLSKFNIEQSKLPTFIGMPIPFAGMCLVILSFTYNPILLAIGTCGLSYLMVSKIKF PHFKKHAAENLESGRWN*" /label="pssA CDS" gene 227718..228251 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /label="pssA gene" CDS 228242..228730 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 14762009, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane phosphatase" /protein_id="NP_388110.1" /db_xref="EnsemblGenomes-Gn:BSU02280" /db_xref="EnsemblGenomes-Tr:CAB12022" /db_xref="GOA:O31453" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG12741" /db_xref="UniProtKB/Swiss-Prot:O31453" /translation="MELVQQLIADYGYLAIFLMLVLGIVGLPIPDEVMMTVVGYFTHT DVLNYELSILISFVGALLGMLISYMIGRKAGRPFIDKYGKWVGLKEKRMMKVEKWMKK YGPYSLILGYFIPGVRHVTCYFSGIGKMDLKTYVAFAAIGAFLWCFVFITIGRVIGII HV*" /label="ybfM CDS" gene 228242..228730 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /label="ybfM gene" CDS 228723..229514 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /EC_number="4.1.1.65" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 9422599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 9422599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine decarboxylase; 32 kDa precursor processed into a 29 kDa protein" /protein_id="NP_388111.1" /db_xref="EnsemblGenomes-Gn:BSU02290" /db_xref="EnsemblGenomes-Tr:CAB12023" /db_xref="GOA:P39822" /db_xref="InterPro:IPR003817" /db_xref="InterPro:IPR033177" /db_xref="InterPro:IPR033178" /db_xref="SubtiList:BG11013" /db_xref="UniProtKB/Swiss-Prot:P39822" /translation="MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSK HFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPN QTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELG NRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELE IGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE*" /label="psd CDS" gene 228723..229514 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /label="psd gene" downshifts 229489 /Source="Nicolas_upshifts" /id="D86" /incds=0 /nref=101 /ntot=236 /MaxReadThrough="3.18138" /MaxDrop="4.25536" /score="-2.98360164" /energy="-8" /TU="U159" /idTUdmin="U160" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 229569..229847 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388112.1" /db_xref="EnsemblGenomes-Gn:BSU02300" /db_xref="EnsemblGenomes-Tr:CAB12024" /db_xref="SubtiList:BG12742" /db_xref="UniProtKB/Swiss-Prot:O31454" /translation="MEKQIISWITDYQNTGDEAVLRQVREVCWPIVEAVLQEKVMDDE QANNLREKGIERFPFIISKYQADVQLPVETFLQNTYRFYFHQVMRESS*" /label="ybfN CDS" gene 229569..229847 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /label="ybfN gene" promotor_-35 229890..229899 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 229908 /Source="Nicolas_upshifts" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 229912..229927 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 229953..231293 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_388113.1" /db_xref="EnsemblGenomes-Gn:BSU02310" /db_xref="EnsemblGenomes-Tr:CAB12025" /db_xref="GOA:O31455" /db_xref="InterPro:IPR007815" /db_xref="SubtiList:BG12743" /db_xref="UniProtKB/Swiss-Prot:O31455" /translation="MKRMIVRMTLPLLIVCLAFSSFSASARAASEEKYWDHWIERHAQ PLDASNASNKDLRFLKKVLKGKRIVQLGETTHGAGEINATKVRMIKYLHEELGYDVLA FESGFPDTNASYLNMDQLTPKSTMKNSIYAVWHTEDVVELFDYMKEQKEKGDPLILTG FDIQSMKNSFNVAATQWVKAVDPEKAELLSQSENDFSTLVTDSNTFDEFSQKKEKLVK NYQKLIKFTKTHASELKENLPKEPKAYEMFMHSLQLRIDVMETYMLEEMKEKLEEYPE NIEDFSFFMRDRMMAEQFQWVADTLYPKKKIIVWGHNYHLRKQNTKMIKDWVQLNGPN MGDYLPERLKKQTYTIGIYAYSGASLDSSDNKTVKPVTSPPPSGSLEALLKAADRPAV FVDFLHTKNKKGTSWMYTPRTALYWGYMEEQMILKEQYDGVIWLEHITPSVIIK*" /label="ybfO CDS" gene 229953..231293 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /label="ybfO gene" downshifts 231293 /Source="Nicolas_upshifts" /id="D87" /incds=0 /nref=12 /ntot=60 /MaxReadThrough="3.64301" /MaxDrop="6.34998" /score="14.4442651" /energy="-13.3" /TU="U161" /idTUdmin="U162" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" upshifts 231359 /Source="Nicolas_upshifts" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="upshifts" misc_feature 231362..231381 /Source="Nicolas_upshift_promotors" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 231401..232288 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388114.1" /db_xref="EnsemblGenomes-Gn:BSU02320" /db_xref="EnsemblGenomes-Tr:CAB12026" /db_xref="GOA:O31456" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12744" /db_xref="UniProtKB/Swiss-Prot:O31456" /translation="MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQK EVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGA YRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQ DIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSN RPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEM PGELLDEPVNLSFEEELQK*" /label="ybfP CDS" gene 231401..232288 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /label="ybfP gene" S_feature 232289..232432 /Source="Nicolas_S_feature" /locus_tag="new_252315_252458" /HighExp="T0.30H, T-1.40H, T0.0H, T-1.10H, Salt, aero, ferm, T-0.40H, T-2.40H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.838, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S89" promotor_-35 232404..232411 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 232425..232444 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 232434 /Source="Nicolas_upshifts" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 232488..233456 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with rhodanese domain" /protein_id="NP_388115.1" /db_xref="EnsemblGenomes-Gn:BSU02330" /db_xref="EnsemblGenomes-Tr:CAB12027" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR020936" /db_xref="InterPro:IPR022111" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG12745" /db_xref="UniProtKB/Swiss-Prot:O31457" /translation="MEKQYRVLLYYKYVPIEDPEAFREQHLAFCKELGLLGRILVSSE GINGTVSGTVEQTEKYMETMKADPRFADMVFKIDEAEGHAFKKIFVRHKKELVTLRLE DDVDPNETTGQHLKPAEFYEKMQDPNTIVIDARNDYEYDLGHFRGAVRPDIEAFRELP EWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLVKQGFEDVAQLDGGIVTYGKDPEVQG KLWDGQCYVFDERISVPVNRVEHVIVGKDYFTGEPCERYVNCANPSCNKKMICTPENE YKYMRSCSHECRTNPRNLYVKEHNMTEEEVNARLAAIETEDHAAAE*" /label="ybfQ CDS" gene 232488..233456 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /label="ybfQ gene" promotor_-10 complement(233310..233328) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(233327) /Source="Nicolas_upshifts" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(233344..233349) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 233453 /Source="Nicolas_upshifts" /id="D88" /incds=0 /nref=238 /ntot=271 /MaxReadThrough="2.06825" /MaxDrop="7.49655" /score="4.11635522" /energy="-7.8" /TU="U163" /idTUdmin="U161" /TUdmin=4 /isTUend="TRUE" /label="downshifts" downshifts complement(233492) /Source="Nicolas_upshifts" /id="D89" /incds=0 /nref=59 /ntot=147 /MaxReadThrough="0.54212" /MaxDrop="6.33244" /score="2.56774646" /energy="-7.5" /TU="NA" /idTUdmin="U165" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(233492..234736) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7751298, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7751298, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/glutamate symport protein" /protein_id="NP_388116.1" /db_xref="EnsemblGenomes-Gn:BSU02340" /db_xref="EnsemblGenomes-Tr:CAB12028" /db_xref="GOA:P39817" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11015" /db_xref="UniProtKB/Swiss-Prot:P39817" /translation="MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMI VVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLD LSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA GIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLV GTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRME KYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMT SKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVV SKWEKAFRQKEWVSANSQTESI*" /label="gltP CDS" gene complement(233492..234736) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /label="gltP gene" promotor_-10 complement(234770..234788) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(234779) /Source="Nicolas_upshifts" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(234799..234807) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(234807..234825) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(234823) /Source="Nicolas_upshifts" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(234841..234846) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(234881..236776) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /EC_number="2.7.1.193" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10627040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucosamine-specific enzyme IICBA component" /protein_id="NP_388117.1" /db_xref="EnsemblGenomes-Gn:BSU02350" /db_xref="EnsemblGenomes-Tr:CAB12029" /db_xref="GOA:P39816" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11014" /db_xref="UniProtKB/Swiss-Prot:P39816" /translation="MFKKAFQILQQLGRALMTPVAVLPAAGLLLRFGDKDLLNIPIIK DAGGVVFDNLPLIFAVGVAIGLAGGEGVAGLAAVIGYLILTVTLDNMGKLLGLQPPYE GAEHLIDMGVFGGIIIGLLAAYLYKRFSSIELHPVLGFFSGKRFVPIITSVSSLVIGV IFSFVWPLIQNGINAASSLIADSTVGLFFYATIYRLLIPFGLHHIFYTPFYFMMGEYT DPSTGNTVTGDLTRFFAGDPTAGRFMMGDFPYMIFCLPAVALAIIHTARPEKKKMISG VMISAALTSMLTGITEPVEFSFLFVAPVLYLINSILAGVIFVVCDLFHVRHGYTFSGG GIDYVLNYGLSTNGWVVIPVGIVFAFIYYYLFRFAILKWNLKTPGRETDEDGQNEEKA PVAKDQLAFHVLQALGGQQNIANLDACITRLRVTVHQPSQVCKDELKRLGAVGVLEVN NNFQAIFGTKSDALKDDIKTIMAGGVPATAAALDTVTDKPLKPDSDETFIYPIKGETV SLGDVPDQVFSEKMMGEGFAIIPSEGKVVAPADGEIVSIFPTKHAIGFMSAGGTEILI HVGIDTVKLNGEGFEAHVTSGQAVKQGELLLTFDLNYIKQHAASAITPVIFTNTSEED LKHIQMK*" /label="gamP CDS" gene complement(234881..236776) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /label="gamP gene" downshifts complement(234897) /Source="Nicolas_upshifts" /id="D90" /incds=0 /nref=56 /ntot=192 /MaxReadThrough="1.9947" /MaxDrop="6.51864" /score="5.87664177" /energy="-12.1" /TU="NA" /idTUdmin="U168" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" misc_feature 236642..236661 /Source="Nicolas_upshift_promotors" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 236659 /Source="Nicolas_upshifts" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(236797..237546) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /EC_number="3.5.99.6" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:23667565, 27002132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 27002132; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate deaminase" /protein_id="NP_388118.1" /db_xref="EnsemblGenomes-Gn:BSU02360" /db_xref="EnsemblGenomes-Tr:CAB12030" /db_xref="GOA:O31458" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="SubtiList:BG12746" /db_xref="UniProtKB/Swiss-Prot:O31458" /translation="MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLY KQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIP QGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSES TIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTT DVPASILQKHNHVTVIADYKAAQKLKSASFS*" /label="gamA CDS" gene complement(236797..237546) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /label="gamA gene" S_feature 237519..237700 /Source="Nicolas_S_feature" /locus_tag="new_257545_257726" /HighExp="H2O2, T1.30H, G135, dia15, G150, G180, LBGstat, T2.0H, T0.30H, M9-stat" /AntisenseName="nagBB" /AntisenseCor="0.458837556034909" /AntisenseRegPval="-14.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S90" S_feature complement(237547..237617) /Source="Nicolas_S_feature" /locus_tag="new_257573_257643_c" /HighExp="S1, Diami, MG 5, MG t5, dia5, MG 15, MG 10, LPhT, Paraq, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S91" promotor_-10 complement(237606..237625) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(237621) /Source="Nicolas_upshifts" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(237641..237648) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 237687..237694 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 237702 /Source="Nicolas_upshifts" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 237707..237726 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 237765..238472 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23667565, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator-GlcN6P (GntR family)" /protein_id="NP_388119.1" /db_xref="EnsemblGenomes-Gn:BSU02370" /db_xref="EnsemblGenomes-Tr:CAB12031" /db_xref="GOA:O31459" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12747" /db_xref="UniProtKB/Swiss-Prot:O31459" /translation="MTALYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTV RLALQQLELEGYIKRIQGKGTFVSAAKIQTPIPHKITSFAEQMRGLRSESKVLELVVI PADHSIAELLKMKENEPVNKLVRVRYAEGEPLQYHTSYIPWKAAPGLAQEECTGSLFE LLRTKYNIEISRGTESIEPILTDETISGHLLTNVGAPAFLSESLTYDKNEEVVEYAQI ITRGDRTKFTVEQSYHS*" /label="gamR CDS" gene 237765..238472 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /label="gamR gene" promotor_-35 238438..238439 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 238455..238469 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 238465 /Source="Nicolas_upshifts" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="upshifts" CDS 238506..238781 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12897008, 23667565" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (B. subtilis-specific)" /protein_id="NP_388120.1" /db_xref="EnsemblGenomes-Gn:BSU02380" /db_xref="EnsemblGenomes-Tr:CAB12032" /db_xref="GOA:O31460" /db_xref="InterPro:IPR012867" /db_xref="SubtiList:BG12748" /db_xref="UniProtKB/Swiss-Prot:O31460" /translation="MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDL TVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL*" /label="ybgB CDS" gene 238506..238781 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /label="ybgB gene" promotor_-10 complement(238564..238582) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(238570) /Source="Nicolas_upshifts" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(238597..238603) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 238773 /Source="Nicolas_upshifts" /id="D91" /incds=0 /nref=20 /ntot=130 /MaxReadThrough="2.42422" /MaxDrop="3.75723" /score="4.58454735" /energy="-9.4" /TU="NA" /idTUdmin="U169" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 238824..238828 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 238844..238863 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 238850 /Source="Nicolas_upshifts" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="upshifts" S_feature 238861..238989 /Source="Nicolas_S_feature" /locus_tag="new_258887_259015" /HighExp="T2.30H, S5, T2.0H, T1.30H, M9-stat, T3.0H, T3.30H, S4, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S92" CDS 238990..240060 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15060025, 15102328, 20332210, 23429746" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15060025, 15102328, 20332210, 23429746; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucine-valine aminotransferase / aromatic amino acid aminotransferase" /protein_id="NP_388121.1" /db_xref="EnsemblGenomes-Gn:BSU02390" /db_xref="EnsemblGenomes-Tr:CAB12033" /db_xref="GOA:O31461" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG12749" /db_xref="UniProtKB/Swiss-Prot:O31461" /translation="MNKLIEREKTVYYKEKPDPSSLGFGQYFTDYMFVMDYEEGIGWH HPRIAPYAPLTLDPSSSVFHYGQAVFEGLKAYRTDDGRVLLFRPDQNIKRLNRSCERM SMPPLDEELVLEALTQLVELEKDWVPKEKGTSLYIRPFVIATEPSLGVKASRSYTFMI VLSPVGSYYGDDQLKPVRIYVEDEYVRAVNGGVGFAKTAGNYAASLQAQRKANELGYD QVLWLDAIEKKYVEEVGSMNIFFVINGEAVTPALSGSILSGVTRASAIELIRSWGIPV REERISIDEVYAASARGELTEVFGTGTAAVVTPVGELNIHGKTVIVGDGQIGDLSKKL YETITDIQLGKVKGPFNWTVEV*" /label="ilvE CDS" gene 238990..240060 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /label="ilvE gene" downshifts 240049 /Source="Nicolas_upshifts" /id="D92" /incds=0 /nref=124 /ntot=245 /MaxReadThrough="1.34575" /MaxDrop="6.88046" /score="13.1364544" /energy="-9.4" /TU="NA" /idTUdmin="U172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(240097..241509) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid permease" /protein_id="NP_388122.1" /db_xref="EnsemblGenomes-Gn:BSU02400" /db_xref="EnsemblGenomes-Tr:CAB12034" /db_xref="GOA:O31462" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12750" /db_xref="UniProtKB/Swiss-Prot:O31462" /translation="MNSAHNKNETTFQRSMKSRHLFMLSLGGVIGTGLFLSSGYTIQQ AGPAGTILAYLVGAGIVYLVMLCLGELSVAMPVTGAFHTYAAKYIGPGTGFTVAWLYW LTWTVALGSEFTAAGLLMQRWFPHTSVWMWSAVFALFIFLLNAFSVKFFAESEFWFSS IKVLAIVLFILLGGSAMFGIIPIKGGEAAPMLSNFTAEGGLFPNGFVPILMTMLSVNF AFSGTELIGIAAGESVDPDKTIPKAIKTTVWRLSLFFVGTIFVLSGLIPIQDAGVIKS PFVAVFDRVGVPYAADIMNFVILTAILSAANSGLYASSRMLWSLSKEKTLHPTFAKLT SKGTPFNALVFSMIGGILSLLSSVFAPDTVYVVLVSISGFAVVVVWMGIAASQFMFRK RYIEAGNKVTDLKYRTPLYPFVPIAAFLLCLASVVGIAFDPNQRIALYCGVPFMAICY AIYYVKNRKSQPAADMTHSK*" /label="ybgF CDS" gene complement(240097..241509) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /label="ybgF gene" downshifts complement(240114) /Source="Nicolas_upshifts" /id="D93" /incds=0 /nref=43 /ntot=166 /MaxReadThrough="0.37503" /MaxDrop="5.92001" /score="6.94246417" /energy="-9.4" /TU="NA" /idTUdmin="U173" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(241510..241621) /Source="Nicolas_S_feature" /locus_tag="new_261536_261647_c" /HighExp="BMM, S1, MG 45, MG 60, UNK1, MG t5, MG 10, MG 90, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S93" promotor_-10 complement(241594..241613) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(241621) /Source="Nicolas_upshifts" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(241628..241635) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(241630..242577) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11267663, 15995196, 17264075; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homocysteine methylase using (R,S)AdoMet" /protein_id="NP_388123.1" /db_xref="EnsemblGenomes-Gn:BSU02410" /db_xref="EnsemblGenomes-Tr:CAB12035" /db_xref="GOA:O31463" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR017226" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG12751" /db_xref="UniProtKB/Swiss-Prot:O31463" /translation="MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEE PELIKQVHTDYFAAGADCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDE FWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDE HRQIAALGINCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESY GASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT*" /label="ybgG CDS" gene complement(241630..242577) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /label="ybgG gene" promotor_-10 complement(242615..242634) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-10" upshifts complement(242632) /Source="Nicolas_upshifts" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="upshifts" promotor_-35 complement(242649..242656) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-35" CDS complement(242706..244142) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 15995196, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine transporter" /protein_id="NP_388124.2" /db_xref="EnsemblGenomes-Gn:BSU02420" /db_xref="EnsemblGenomes-Tr:CAB12036" /db_xref="GOA:O31464" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12752" /db_xref="UniProtKB/Swiss-Prot:O31464" /translation="MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRML KEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWI IAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGI VFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVL YIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMG SAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQ ASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAM IVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFY KDVLKNHNGIECWPVSDTKTDTHNKQIS*" /label="glnT CDS" gene complement(242706..244142) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /label="glnT gene" downshifts complement(242721) /Source="Nicolas_upshifts" /id="D94" /incds=0 /nref=3 /ntot=3 /MaxReadThrough="0.598370000000001" /MaxDrop="4.3935" /score="-7.90227391" /energy="-11.4" /TU="NA" /idTUdmin="U174" /TUdmin="-1078" /isTUend="FALSE" /label="downshifts" CDS complement(244165..245148) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15995196, 18459799, 20050917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995196, 18459799, 20050917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutaminase" /protein_id="NP_388125.1" /db_xref="EnsemblGenomes-Gn:BSU02430" /db_xref="EnsemblGenomes-Tr:CAB12037" /db_xref="GOA:O31465" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="PDB:1MKI" /db_xref="PDB:2OSU" /db_xref="PDB:3AGF" /db_xref="PDB:3BRM" /db_xref="SubtiList:BG12753" /db_xref="UniProtKB/Swiss-Prot:O31465" /translation="MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKV NDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPT GDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRP RIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIG LILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIM ALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF*" /label="glsA CDS" gene complement(244165..245148) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /label="glsA gene" promotor_-10 complement(245242..245259) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 245247..245266 /Source="Nicolas_upshift_promotors" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(245249) /Source="Nicolas_upshifts" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 245253 /Source="Nicolas_upshifts" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(245275..245282) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 245450..246682 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196, 17001076, 21435182, 23461034, 25691471; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [GlnL] forglutamine degradation" /protein_id="NP_388126.2" /db_xref="EnsemblGenomes-Gn:BSU02440" /db_xref="EnsemblGenomes-Tr:CAB12038" /db_xref="GOA:P40758" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10871" /db_xref="UniProtKB/Swiss-Prot:P40758" /translation="MLITVPLAGELKFYPLNEEFRVSFGAPVFFFFLSLLRHVPAVLP GFLTGAAVFIFRVFLELWGGGHNGLTPILYDQASGFFFYMTYACLFSILKANRFRERP IMLGFIGFMIEVVSDCVELTVQFLIFHTVVTPEKITDIAVIAISHTFIVMSFYSVLKL YETQSREKQTRQQHEHMLMIVSNLYEETVHLKKTLKTTEKVTNDSYQLYREMKGKDVQ LSGRILRLAGEIHEVKKDNQRIFAGLSKLISNESLRDYMRASDLLQLVIRMNEKYAEA LGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESMVEF QVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ RGVVFAIRLPVRHLIQKG*" /label="glnJ CDS" gene 245450..246682 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /label="glnJ gene" CDS 246693..247637 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [GlnJ] for glutamine utilisation" /protein_id="NP_388127.1" /db_xref="EnsemblGenomes-Gn:BSU02450" /db_xref="EnsemblGenomes-Tr:CAB12039" /db_xref="GOA:P40759" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013972" /db_xref="SubtiList:BG10872" /db_xref="UniProtKB/Swiss-Prot:P40759" /translation="MRFFIADDDRAVRSILRQIIEDEDLGEAAGEADDGSQVEGHMLQ FKQIDILLIDLLMPGRDGIETIRQIQNTYSGKIVMISQVEAKEMVGEAYSLGIEYFIH KPINRIEIVTVLQKVKERIELEHSIGAIQHSLSRLVNRTERKARPQQKSDSGLKEAGT FLLSELGMMGEGGAHDLMAVLQYLAEHEQSEPHEKQSPSLKQIFTQVAVRKLGTGASQ TEVNREMKASEQRIRRAIIHSLHHFASLGTTDFSNPKFETYASKFFDFPVVSQKMKEL QSKDAKPLAPARINMKKFIHVFFLEAKLLHETMKQRRI*" /label="glnL CDS" gene 246693..247637 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /label="glnL gene" downshifts 247614 /Source="Nicolas_upshifts" /id="D95" /incds=0 /nref=45 /ntot=191 /MaxReadThrough="1.43757" /MaxDrop="3.64091" /score="2.73020459" /energy="-6.2" /TU="NA" /idTUdmin="U177" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" promotor_-35 247734..247741 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 247746..247863 /Source="Nicolas_S_feature" /locus_tag="new_267772_267889" /HighExp="Sw, BC, M40t90, Etha, MG-0.2, HiTm, HiOs, G135, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S94" upshifts 247746 /Source="Nicolas_upshifts" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 247755..247774 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 247864..248790 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /EC_number="4.2.1.41" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5-dehydro-4-deoxyglucarate dehydratase" /protein_id="NP_388128.2" /db_xref="EnsemblGenomes-Gn:BSU02460" /db_xref="EnsemblGenomes-Tr:CAB12040" /db_xref="GOA:P42235" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017655" /db_xref="SubtiList:BG11158" /db_xref="UniProtKB/Swiss-Prot:P42235" /translation="MSRIRKAPAGILGFPVAPFNTQGKLEEEALFQNIEFLLNEGLEA IFIACGSGEFQSLSQKEYEQMVEVAVSAAGGKVPVYTGVGGNLSTALDWAQLSEKKGA DGYLILPPYLVHGEQEGLYQYAKTIIESTDLNAILYQRDNAVLSVEQIKRLTECEQLV GVKDGVGNMDLNINLVYTIGDRLGWLNGMPMAEVTMPAYLPIGFHSYSSAISNYIPHI SRMFYDALKNGNDELVKELYRHVILPINDIRKQRKGYAVSLIKAGMEIMGLNVRNTAR PPVGPVEKDHYQQLEAILKQAADRFPKKAATV*" /label="kdgD CDS" gene 247864..248790 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /label="kdgD gene" CDS 248820..250286 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /EC_number="1.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674, 17202142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase)" /protein_id="NP_388129.1" /db_xref="EnsemblGenomes-Gn:BSU02470" /db_xref="EnsemblGenomes-Tr:CAB12041" /db_xref="GOA:P42236" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11159" /db_xref="UniProtKB/Swiss-Prot:P42236" /translation="MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQN STAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTL PEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPV AIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQ GLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEA VITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASK NQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIF GPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAG VELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP*" /label="gucD CDS" gene 248820..250286 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /label="gucD gene" CDS 250370..251737 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12044674, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucarate transporter" /protein_id="NP_388130.2" /db_xref="EnsemblGenomes-Gn:BSU02480" /db_xref="EnsemblGenomes-Tr:CAB12042" /db_xref="GOA:P42237" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11160" /db_xref="UniProtKB/Swiss-Prot:P42237" /translation="MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGD SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQ GAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYI EQGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVY LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLL SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGN IASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDPD QSLPV*" /label="gudP CDS" gene 250370..251737 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /label="gudP gene" CDS 251774..253141 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /EC_number="4.2.1.40" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772161, 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucarate dehydratase" /protein_id="NP_388131.2" /db_xref="EnsemblGenomes-Gn:BSU02490" /db_xref="EnsemblGenomes-Tr:CAB12043" /db_xref="GOA:P42238" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR017653" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR034598" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11161" /db_xref="UniProtKB/Swiss-Prot:P42238" /translation="MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSP FFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFG DQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGY LFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKG GVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDE NGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVR VAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPF EISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKR PCLVR*" /label="gudD CDS" gene 251774..253141 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /label="gudD gene" promotor_-35 253155..253162 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-35" promotor_-10 253177..253194 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-10" upshifts 253180 /Source="Nicolas_upshifts" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="upshifts" CDS 253211..253912 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12044674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388132.2" /db_xref="EnsemblGenomes-Gn:BSU02500" /db_xref="EnsemblGenomes-Tr:CAB12044" /db_xref="GOA:P42239" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11162" /db_xref="UniProtKB/Swiss-Prot:P42239" /translation="MYEGLEDLKVDTVNRKTLAKQVIERIVHLLSSGQLRAGDKLPTE MELMDILHVSRPVLREALSSLETLGVITRKTRGGTYFNDKIGMQPFSVMLALATDNLP AIIEARMALELGLVTIAAEKINEEELQRLQKTIDDIANSTDNHYGEADKEFHRIIALS ANNPVVEGMIQSLLITHAKIDSQIPYRERDVTVEYHKKIYDALAKRDPYKAHYHMYEH LKFVRDKILKGMDEK*" /label="garR CDS" gene 253211..253912 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /label="garR gene" downshifts 253862 /Source="Nicolas_upshifts" /id="D96" /incds=0 /nref=1 /ntot=35 /MaxReadThrough="3.59234" /MaxDrop="2.3923" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" downshifts 253906 /Source="Nicolas_upshifts" /id="D97" /incds=0 /nref=1 /ntot=82 /MaxReadThrough="3.21794" /MaxDrop="2.49226" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS 254003..255535 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /EC_number="4.2.1.42" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772162; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-galactarate dehydratase" /protein_id="NP_388133.2" /db_xref="EnsemblGenomes-Gn:BSU02510" /db_xref="EnsemblGenomes-Tr:CAB12045" /db_xref="GOA:P42240" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR017654" /db_xref="SubtiList:BG11163" /db_xref="UniProtKB/Swiss-Prot:P42240" /translation="MAMNLRKNQAPLYIKVHEIDNTAIIVNDGGLPKGTVFSCGLVLE EDVPQGHKVALTDLNQGDEIVRYGEVIGFADETIKRGSWIREALVRMPAPPALDDLPL ANRVPQPRPPLEGYTFEGYRNADGSAGTKNILGITTSVQCVVGVLDYAVKRIKEELLP KYPNVDDVVPLHHQYGCGVAINAPDAVIPIRTIQNLAKHPNFGGEVMVIGLGCEKLLP ERIASENDDDILSLQDHRGFAAMIQSILEMAEERLIRLNSRTRVSCPVSDLVIGLQCG GSDAFSGVTANPAVGYAADLLVRAGATVLFSEVTEVRDAIHLLTPRAVSEEVGQSLIK EMKWYDSYLRRGDADRSANPSPGNKKGGLSNVVEKALGSVAKSGTSPISGVLGPGERA KQKGLLFAATPASDFVCGTLQLAAGMNLQVFTTGRGTPYGLAAAPVLKVSTRHSLSEH WADLIDINAGRIATGEASIEDVGWEIFRTILDVASGRKQTWADRWGLHNDLCLFNPAP VT*" /label="garD CDS" gene 254003..255535 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /label="garD gene" promotor_-35 255547..255550 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 255565..255584 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 255577..255811 /Source="Nicolas_S_feature" /locus_tag="new_275603_275837" /HighExp="LoTm, Sw, BC, BI, B60, B36, T3.30H, T5.0H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.50265400000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S95" upshifts 255577 /Source="Nicolas_upshifts" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 255812..256732 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_388134.1" /db_xref="EnsemblGenomes-Gn:BSU02520" /db_xref="EnsemblGenomes-Tr:CAB12046" /db_xref="GOA:P42242" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG11165" /db_xref="UniProtKB/Swiss-Prot:P42242" /translation="MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAK DDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGT PAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFR QMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRV TGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAA YPVEIAKLALQTQQEEHINMALEALGVTSD*" /label="ycbJ CDS" gene 255812..256732 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /label="ycbJ gene" promotor_-35 256734..256741 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 256756..256775 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 256766 /Source="Nicolas_upshifts" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 256789..257036 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /product="T-box riboswitch specific of tryptophan tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 10706627, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 10706627, 12165569, 12547201; Product type n: RNA" /label="tboW RNA" gene 256789..257036 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /label="tboW gene" downshifts 257005 /Source="Nicolas_upshifts" /id="D98" /incds=0 /nref=225 /ntot=264 /MaxReadThrough="2.36361" /MaxDrop="6.52913" /score="36.5571172" /energy="-16.6" /TU="NA" /idTUdmin="U179" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS 257134..257295 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-TRAP regulator" /protein_id="NP_388135.1" /db_xref="EnsemblGenomes-Gn:BSU02530" /db_xref="EnsemblGenomes-Tr:CAB12047" /db_xref="GOA:O31466" /db_xref="InterPro:IPR031538" /db_xref="InterPro:IPR036410" /db_xref="PDB:2BX9" /db_xref="PDB:2KO8" /db_xref="PDB:2ZP8" /db_xref="PDB:2ZP9" /db_xref="SubtiList:BG12776" /db_xref="UniProtKB/Swiss-Prot:O31466" /translation="MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLL DFIQKHLNK*" /label="rtpA CDS" gene 257134..257295 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /label="rtpA gene" promotor_no_box 257212..257312 /Source="Nicolas_upshift_promotors" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 257272 /Source="Nicolas_upshifts" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 257316..258254 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10706627, 15063849, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative tryptophan or indole exporter" /protein_id="NP_388136.1" /db_xref="EnsemblGenomes-Gn:BSU02540" /db_xref="EnsemblGenomes-Tr:CAB12048" /db_xref="GOA:P42243" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG11166" /db_xref="UniProtKB/Swiss-Prot:P42243" /translation="MRAEEQSKIREAAAGTIFLLIGTVCFASKSIWIKWAYQMGAEPD AVLLYRQLLAVPLFWLIFLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNH VSAMVERILLMSYPLFVFGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQA NMIGAVFILLSSAVYAGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMMLYTGIKSAAGM NTPMAAYPLSMYGLFAVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGA LFLGERLGLIQVIGCGGVFFVITGMEYRKLKTGKKE*" /label="ycbK CDS" gene 257316..258254 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /label="ycbK gene" downshifts 257360 /Source="Nicolas_upshifts" /id="D99" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="3.05417" /MaxDrop="3.72787" /score="0.773303272" /energy="-9" /TU="NA" /idTUdmin="U181" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 258277..258296 /Source="Nicolas_upshift_promotors" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 258282..258350 /Source="Nicolas_S_feature" /locus_tag="new_278308_278376" /HighExp="C90, dia5, Lbtran, Lbexp, LBGexp, SMM, dia0, dia15, BMM, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S96" upshifts 258282 /Source="Nicolas_upshifts" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="upshifts" CDS 258351..259031 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YcbM]" /protein_id="NP_388137.2" /db_xref="EnsemblGenomes-Gn:BSU02550" /db_xref="EnsemblGenomes-Tr:CAB12049" /db_xref="GOA:P42244" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11167" /db_xref="UniProtKB/Swiss-Prot:P42244" /translation="MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDL VLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMI ELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLL CLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWG IGYKLGEF*" /label="ycbL CDS" gene 258351..259031 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /label="ycbL gene" CDS 259033..259968 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YcbL]" /protein_id="NP_388138.2" /db_xref="EnsemblGenomes-Gn:BSU02560" /db_xref="EnsemblGenomes-Tr:CAB12050" /db_xref="GOA:P42245" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11168" /db_xref="UniProtKB/Swiss-Prot:P42245" /translation="MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRD SAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLT VILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITK VHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYG AAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGL TITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY*" /label="ycbM CDS" gene 259033..259968 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /label="ycbM gene" CDS 260060..260983 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388139.2" /db_xref="EnsemblGenomes-Gn:BSU02570" /db_xref="EnsemblGenomes-Tr:CAB12051" /db_xref="GOA:P42246" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11169" /db_xref="UniProtKB/Swiss-Prot:P42246" /translation="MTYIVQTNGLTKTYQGKEVVSNVSMHIKKGEIYGFLGPNGAGKT TIMKMLTSLVKPTSGEIIILGNKFTHTSYEVLGNIGSMIEYPIFYENLTAEENLDLHC EYMGYHNKKAIQEVLDMVNLKQIDKKPVKTFSLGMKQRLGIARAILTKPDLLILDEPV NGLDPLGIKKIRQLFQVLSKEYGMTLLISSHLLGEIEQIADTIGVIRDGRLLEEVSME DVRGQNTEYIELVTPNQTRACFVLEKELQLTNFKILNEKTIRIYEAEASQAAISKALI LNDVDIESMNKKYTSLEDYFIKLINGNSISA*" /label="ycbN CDS" gene 260060..260983 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /label="ycbN gene" S_feature complement(260530..261714) /Source="Nicolas_S_feature" /locus_tag="new_280556_281740_c" /HighExp="Etha, Sw, Gly, B36, LoTm, B60, GM 150, Salt, C30, ferm" /AntisenseName="ycbO" /AntisenseCor="-0.38911425676406203" /AntisenseRegPval="-10.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S97" CDS 261002..261688 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven exporter" /protein_id="NP_388140.3" /db_xref="EnsemblGenomes-Gn:BSU02580" /db_xref="EnsemblGenomes-Tr:CAB12052" /db_xref="GOA:P42247" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11170" /db_xref="UniProtKB/Swiss-Prot:P42247" /translation="MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGV SFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAK LMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAG TSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYM AIRNADKQDA*" /label="ycbO CDS" gene 261002..261688 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /label="ycbO gene" CDS complement(261649..261783) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513940.1" /translation="MARSIILKQEQTHNGKAGADSIGLLYILGAFVYASCLSAFLIAM *" /label="hypothetical protein CDS" gene complement(261649..261783) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /label="gene" downshifts 261683 /Source="Nicolas_upshifts" /id="D100" /incds=0 /nref=8 /ntot=120 /MaxReadThrough="1.13131" /MaxDrop="3.44039" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" CDS complement(261743..262129) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22582280; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative inner integral membrane protein" /protein_id="NP_388141.1" /db_xref="EnsemblGenomes-Gn:BSU02590" /db_xref="EnsemblGenomes-Tr:CAB12053" /db_xref="GOA:P42248" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG11171" /db_xref="UniProtKB/Swiss-Prot:P42248" /translation="MTHVKALAIKGIMTIIVLYLVLGLGFGFTFGDTLLMTIVLGVIS YLLGDLYVLPKWNNMIATLADFGLAFLVIWLMGMPLSMGMTGGEVALAALFGAIVMAI GEYCFHFYMMSKEIGKKHYLETRTDS*" /label="ycbP CDS" gene complement(261743..262129) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /label="ycbP gene" downshifts complement(261759) /Source="Nicolas_upshifts" /id="D101" /incds=0 /nref=148 /ntot=217 /MaxReadThrough="6.64196" /MaxDrop="7.40353" /score="13.8182557" /energy="-15.6" /TU="U183" /idTUdmin="U185" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(262155..262173) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(262174) /Source="Nicolas_upshifts" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(262187..262193) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(262207..263205) /Source="Nicolas_S_feature" /locus_tag="new_282233_283231_c" /HighExp="GM 150, T0.30H, C30, T1.30H, T1.0H, T-0.40H, T-3.40H, T2.0H, T2.30H, T-4.40H" /AntisenseName="cwlJ" /AntisenseCor="0.11463160303596701" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S98" downshifts complement(262250) /Source="Nicolas_upshifts" /id="D102" /incds=0 /nref=3 /ntot=10 /MaxReadThrough="5.23914" /MaxDrop="3.14515" /score="13.8182557" /energy="-15.6" /TU="U185,U187" /idTUdmin="U185" /TUdmin="-491" /isTUend="FALSE" /label="downshifts" promotor_-35 262386..262391 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 262405 /Source="Nicolas_upshifts" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 262407..262425 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(262419) /Source="Nicolas_upshifts" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(262421..262435) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(262441) /Source="Nicolas_upshifts" /id="D103" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="5.64474" /MaxDrop="3.76775" /score="13.8182557" /energy="-15.6" /TU="U187" /idTUdmin="U185" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 complement(262443..262447) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 262443..262871 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore cortex cell wall hydrolase" /protein_id="NP_388142.2" /db_xref="EnsemblGenomes-Gn:BSU02600" /db_xref="EnsemblGenomes-Tr:CAB12054" /db_xref="GOA:P42249" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG11172" /db_xref="UniProtKB/Swiss-Prot:P42249" /translation="MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRAN CSDFKGLRTIRQMIYQPHAFEAVTHGYFYQRARDSERALARRSINGERRWPAKFSLWY FRPQGDCPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF*" /label="cwlJ CDS" gene 262443..262871 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /label="cwlJ gene" downshifts 262850 /Source="Nicolas_upshifts" /id="D104" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.30044" /MaxDrop="5.89045" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 262916..262922 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 262935..262954 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 262937 /Source="Nicolas_upshifts" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="upshifts" CDS 262977..263708 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388143.2" /db_xref="EnsemblGenomes-Gn:BSU02610" /db_xref="EnsemblGenomes-Tr:CAB12055" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR019303" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG11173" /db_xref="UniProtKB/Swiss-Prot:P42250" /translation="MATIDLQKKSVKIVLEKKQLTKVTARVGLVLDITGSMRPLYKNG TVQNVVERILAVADQFDDNGLLDVWVYDNEFSRLKPVSEKDFSGYVDREILNNDRLHK FGRNDEPPVMKDVLRKYVTEEPSSYPAFIVFINDGGCKKSIKPIIEASSDKPVFWQFV GIGNGNFDFLNKLDTLEGRVIDNTNFLHIEEIDRISDDELYDALLAEFPFWLKEAKEK GIVREQEPPAEKPKKKGFFSRLFSK*" /label="ycbR CDS" gene 262977..263708 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /label="ycbR gene" promotor_-10 complement(263179..263198) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(263205) /Source="Nicolas_upshifts" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(263212..263219) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 263626 /Source="Nicolas_upshifts" /id="D105" /incds=1 /nref=9 /ntot=148 /MaxReadThrough="1.70712" /MaxDrop="3.61288" /score="25.6672471" /energy="-14.1" /TU="NA" /idTUdmin="U186" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 263790..263966 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097673.1" /db_xref="EnsemblGenomes-Gn:BSU02619" /db_xref="EnsemblGenomes-Tr:CAX52543" /db_xref="UniProtKB/Swiss-Prot:C0H3T2" /translation="MGGLQTTGYAENASFSQLSACFSSRLVREDLFLMFSAYNQFTLL HSRLTMISYNGDDQ*" /label="yczK CDS" gene 263790..263966 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /label="yczK gene" promotor_-35 263918..263924 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 263931..263948 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 263942 /Source="Nicolas_upshifts" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="upshifts" CDS 263985..265736 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted phosphodiesterase (endo-hydrolysis at non-specific sites throughout the cell wall teichoic acid polymer)" /protein_id="NP_388144.2" /db_xref="EnsemblGenomes-Gn:BSU02620" /db_xref="EnsemblGenomes-Tr:CAB12056" /db_xref="GOA:P42251" /db_xref="InterPro:IPR008963" /db_xref="InterPro:IPR018946" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR032093" /db_xref="PDB:2YEQ" /db_xref="SubtiList:BG11174" /db_xref="UniProtKB/Swiss-Prot:P42251" /translation="MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLT IAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPV KWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKT KTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYV SKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANK IPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDT RQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAK WNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFE KTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQW KADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSH NKAHEKQMIKKRAKITN*" /label="phoD CDS" gene 263985..265736 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /label="phoD gene" promotor_-10 complement(264039..264054) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264045) /Source="Nicolas_upshifts" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(264067..264076) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 265749..265961 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867413, 15554971, 16678787, 19049517, 21479530, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867413, 15554971, 16678787, 19049517, 21479530, 27984091; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388145.2" /db_xref="EnsemblGenomes-Gn:BSU02630" /db_xref="EnsemblGenomes-Tr:CAB12057" /db_xref="GOA:O31467" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR003998" /db_xref="InterPro:IPR006312" /db_xref="PDB:2L16" /db_xref="SubtiList:BG12777" /db_xref="UniProtKB/Swiss-Prot:O31467" /translation="MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSAT KSLVSGDEKEEKSAELTAVKQDKNAG*" /label="tatAD CDS" gene 265749..265961 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /label="tatAD gene" S_feature 265962..266021 /Source="Nicolas_S_feature" /locus_tag="new_285988_286047" /HighExp="LPhT, BI, Paraq, C90, H2O2, M40t90, C30, M0t90, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0569" /TUlongSig="NA" /TUlongPSig="NA" /label="S99" CDS 266022..266750 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16698798, 19049517, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16698798, 19049517, 27984091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388146.2" /db_xref="EnsemblGenomes-Gn:BSU02640" /db_xref="EnsemblGenomes-Tr:CAB12058" /db_xref="GOA:P42252" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG11175" /db_xref="UniProtKB/Swiss-Prot:P42252" /translation="MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWL IRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLM YIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGF LFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVL FEVSVTLSAFVYKKRMREETAAAA*" /label="tatCD CDS" gene 266022..266750 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /label="tatCD gene" downshifts complement(266030) /Source="Nicolas_upshifts" /id="D106" /incds=0 /nref=4 /ntot=146 /MaxReadThrough="1.2763" /MaxDrop="3.13944" /score="-9.00478071" /energy="-8.5" /TU="NA" /idTUdmin="U190" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(266747..267394) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /EC_number="3.4.19.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1362573, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1362573, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrrolidone-carboxylate (pyroglutamate) peptidase" /protein_id="NP_388147.1" /db_xref="EnsemblGenomes-Gn:BSU02650" /db_xref="EnsemblGenomes-Tr:CAB12059" /db_xref="GOA:P28618" /db_xref="InterPro:IPR000816" /db_xref="InterPro:IPR016125" /db_xref="InterPro:IPR029762" /db_xref="InterPro:IPR033693" /db_xref="InterPro:IPR033694" /db_xref="InterPro:IPR036440" /db_xref="SubtiList:BG10873" /db_xref="UniProtKB/Swiss-Prot:P28618" /translation="MRKKVLITGFDPFDKETVNPSWEAAKRLNGFETEEAIITAEQIP TVFRSALDTLRQAIQKHQPDIVICVGQAGGRMQITPERVAINLADARIPDNEGHQPID EEISPDGPAAYWTRLPVKRMTAKMKEHGIPAAVSYTAGTFVCNYLFYGLMDHISRTSP HIRGGFIHIPYIPQQTIDKTAPSLSLDTIVRALRIAAVTAAQYDEDVKSPGGTLH*" /label="pcp CDS" gene complement(266747..267394) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /label="pcp gene" promotor_-10 complement(267409..267428) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 267422..267428 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(267423) /Source="Nicolas_upshifts" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(267443..267447) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 267443..267462 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 267445 /Source="Nicolas_upshifts" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="upshifts" CDS 267473..268585 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase (PLP-dependent)" /protein_id="NP_388148.2" /db_xref="EnsemblGenomes-Gn:BSU02660" /db_xref="EnsemblGenomes-Tr:CAB12060" /db_xref="GOA:P42253" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG11176" /db_xref="UniProtKB/Swiss-Prot:P42253" /translation="MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSL LYKGTNWKEAIEKTEFARNEFAKLIGAEPDEVAIVPSVSDALVSVASSLTAFGKKHVV YTDMDFPAVPHVWQAHSDYTVSVIPSIDGVLPLEQYETHISDETVLTCVPHVHYRDGY VQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFL YVRKELADALKPKASAWFGRESGFDGAYAKVARRFQTGTPAFISVYAAAAALSLLNHI GVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKV ICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK*" /label="ycbU CDS" gene 267473..268585 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /label="ycbU gene" upshifts complement(267819) /Source="Nicolas_upshifts" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(267822..267841) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(267857..267861) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 268579 /Source="Nicolas_upshifts" /id="D107" /incds=0 /nref=45 /ntot=226 /MaxReadThrough="1.10091" /MaxDrop="4.52742" /score="6.75687898" /energy="-14" /TU="NA" /idTUdmin="U191" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(268627..270066) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 17483215; Product type t: transporter" /codon_start=1 /transl_table=11 /product="flavonoid efflux transporter; drug-export protein" /protein_id="NP_388149.1" /db_xref="EnsemblGenomes-Gn:BSU02670" /db_xref="EnsemblGenomes-Tr:CAB12061" /db_xref="GOA:O35018" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12613" /db_xref="UniProtKB/Swiss-Prot:O35018" /translation="MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLM KELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALA PSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTF SGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGI VFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILG VIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKY GPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQL PREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAG VQHAFVFAMIVAIIGLIGAFFMKRVKVDH*" /label="lmrB CDS" gene complement(268627..270066) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /label="lmrB gene" downshifts complement(268634) /Source="Nicolas_upshifts" /id="D108" /incds=0 /nref=162 /ntot=245 /MaxReadThrough="0.65833" /MaxDrop="6.75228" /score="18.3484535" /energy="-14" /TU="U193" /idTUdmin="U193" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(270106..270672) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12718394, 15317768, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12718394, 15317768, 17483215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of lmrAB and yxaGH operons (flavonoid and antibiotic resistance)" /protein_id="NP_388150.1" /db_xref="EnsemblGenomes-Gn:BSU02680" /db_xref="EnsemblGenomes-Tr:CAB12062" /db_xref="GOA:O34619" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12612" /db_xref="UniProtKB/Swiss-Prot:O34619" /translation="MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYY HFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEG LPVGLLAAETSLKSEPLREACHEAYKEWASVYEEKLRQTGCSESRAKEASTVVNAMIE GGILLSLTAKNSTPLLHISSCIPDLLKR*" /label="lmrA CDS" gene complement(270106..270672) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /label="lmrA gene" promotor_-10 complement(270710..270729) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(270724) /Source="Nicolas_upshifts" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(270744..270751) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 270826..270832 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 270848..270865 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 270854 /Source="Nicolas_upshifts" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="upshifts" CDS 270889..272016 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /EC_number="3.5.1.1" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914346, 17686772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346, 17686772; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-asparaginase 2 (putative lipoprotein)" /protein_id="NP_388151.1" /db_xref="EnsemblGenomes-Gn:BSU02690" /db_xref="EnsemblGenomes-Tr:CAB12063" /db_xref="GOA:O34482" /db_xref="InterPro:IPR004550" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG12755" /db_xref="UniProtKB/Swiss-Prot:O34482" /translation="MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASA SEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQ IVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKP VVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTT TTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGS YLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQD YAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY*" /label="ansZ CDS" gene 270889..272016 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /label="ansZ gene" downshifts 271989 /Source="Nicolas_upshifts" /id="D109" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="1.70459" /MaxDrop="4.27333" /score="23.2201078" /energy="-7.6" /TU="NA" /idTUdmin="U194" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 272113..272119 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 272133..272152 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 272133 /Source="Nicolas_upshifts" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 272179..272817 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8396026, 15812018, 18053819, 11029590, 24827611, 28963005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8396026, 15812018, 18053819, 11029590, 24827611, 28963005; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="secreted alkaliphilic lipase" /protein_id="NP_388152.1" /db_xref="EnsemblGenomes-Gn:BSU02700" /db_xref="EnsemblGenomes-Tr:CAB12064" /db_xref="GOA:P37957" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="PDB:1I6W" /db_xref="PDB:1ISP" /db_xref="PDB:1R4Z" /db_xref="PDB:1R50" /db_xref="PDB:1T2N" /db_xref="PDB:1T4M" /db_xref="PDB:2QXT" /db_xref="PDB:2QXU" /db_xref="PDB:3D2A" /db_xref="PDB:3D2B" /db_xref="PDB:3D2C" /db_xref="PDB:3QMM" /db_xref="PDB:3QZU" /db_xref="PDB:5CRI" /db_xref="PDB:5CT4" /db_xref="PDB:5CT5" /db_xref="PDB:5CT6" /db_xref="PDB:5CT8" /db_xref="PDB:5CT9" /db_xref="PDB:5CTA" /db_xref="PDB:5CUR" /db_xref="SubtiList:BG10679" /db_xref="UniProtKB/Swiss-Prot:P37957" /translation="MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIG GASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKV DIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIY SSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN*" /label="estA CDS" gene 272179..272817 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /label="estA gene" downshifts 272803 /Source="Nicolas_upshifts" /id="D110" /incds=0 /nref=15 /ntot=117 /MaxReadThrough="4.54554" /MaxDrop="4.10395" /score="23.2201078" /energy="-7.6" /TU="U195" /idTUdmin="U194" /TUdmin=814 /isTUend="FALSE" /label="downshifts" S_feature 272848..273438 /Source="Nicolas_S_feature" /locus_tag="new_292874_293464" /HighExp="M9-tran, GM 150, LoTm, MG 150, GM 120, aero, T-1.40H, M/G, S2, GM 90" /AntisenseName="yczC" /AntisenseCor="3.5651747957185502E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S100" CDS complement(272855..273238) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_388153.1" /db_xref="EnsemblGenomes-Gn:BSU02710" /db_xref="EnsemblGenomes-Tr:CAB12065" /db_xref="GOA:O31469" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG12778" /db_xref="UniProtKB/Swiss-Prot:O31469" /translation="MELAGFMLRACALLLDVIIAAAVILAAGFTFGDGSAGVIIVAIL MLIVYPLLMPLTNWKGTLGKKIIGLQIVRDETYKKISFPQAIVRYLIAWVHVFSRLIY LTAAFTKKKQTVHDMAAKTIVLKAE*" /label="yczC CDS" gene complement(272855..273238) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /label="yczC gene" downshifts complement(272879) /Source="Nicolas_upshifts" /id="D111" /incds=0 /nref=4 /ntot=94 /MaxReadThrough="0.85389" /MaxDrop="2.7858" /score="15.0330092" /energy="-12.1" /TU="NA" /idTUdmin="U196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" Polymorphism join(273052,273054) /Source="geneious" /ID="SNP_BsDelta6_293079_293079" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=186 /Change="C -> T" /Codon_Change="CTG -> CTA" /Coverage=154 /locus_tag="BSU_02710" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" promotor_-10 complement(273268..273287) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(273275) /Source="Nicolas_upshifts" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(273301..273308) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 273410..273413 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 273429..273448 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 273440 /Source="Nicolas_upshifts" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 273473..274549 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388154.1" /db_xref="EnsemblGenomes-Gn:BSU02720" /db_xref="EnsemblGenomes-Tr:CAB12066" /db_xref="GOA:O34478" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR007889" /db_xref="InterPro:IPR036915" /db_xref="SubtiList:BG12756" /db_xref="UniProtKB/Swiss-Prot:O34478" /translation="MGKVKRNAPCPCGSGKKYKKCCGSKVVDFPAELAAKEAKQIQED LVEYAFTVHRESISGFINQHDFLSAMDRQTKDISVFNLGIWGIFFHPLAGEKTIFEEY LQKKGDSITRPKTREIVESWQSMTPALLLLKDLKEGIIHFEDVITAKQFEVEMDASNQ DLPPVGSLILGYPIHEAEKAEFFMQFTIFPVKRTEALISKVKKYADAAVKDGKTPEDF MKQEFNNVLFALLAEKDEEPQAEKAEVSTVEWANDLEKETAAAIEEGMSGEEYPTELI PAVIDIWKTFCEKKSPVIRKPEAFAAAVEYYVNAISLNGASVSQAKLAKKYGVSASTI SSRYKEIESTLQDEADRFAQALSS*" /label="yccF CDS" gene 273473..274549 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /label="yccF gene" downshifts 274543 /Source="Nicolas_upshifts" /id="D112" /incds=0 /nref=60 /ntot=248 /MaxReadThrough="1.55048" /MaxDrop="5.18328" /score="33.0000484" /energy="-12.9" /TU="NA" /idTUdmin="U197" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(274589..275545) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [NatR]" /protein_id="NP_388155.1" /db_xref="EnsemblGenomes-Gn:BSU02730" /db_xref="EnsemblGenomes-Tr:CAB12067" /db_xref="GOA:P70954" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR032834" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11997" /db_xref="UniProtKB/Swiss-Prot:P70954" /translation="MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGL YIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQS ALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWA DQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVG NILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTK NGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK*" /label="natK CDS" gene complement(274589..275545) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /label="natK gene" downshifts complement(274617) /Source="Nicolas_upshifts" /id="D113" /incds=0 /nref=1 /ntot=129 /MaxReadThrough="0.86926" /MaxDrop="2.67125" /score="14.02819" /energy="-12.9" /TU="NA" /idTUdmin="U198" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(275558..276259) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [NatK]" /protein_id="NP_388156.1" /db_xref="EnsemblGenomes-Gn:BSU02740" /db_xref="EnsemblGenomes-Tr:CAB12068" /db_xref="GOA:P70955" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11998" /db_xref="UniProtKB/Swiss-Prot:P70955" /translation="MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVK NGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMK PYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTT AEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKA MITKQQLDYFQNYYF*" /label="natR CDS" gene complement(275558..276259) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /label="natR gene" promotor_-10 complement(276283..276302) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(276289) /Source="Nicolas_upshifts" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(276318..276321) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 276339..276342 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 276358..276377 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 276368 /Source="Nicolas_upshifts" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 276403..277143 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10356997, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388157.1" /db_xref="EnsemblGenomes-Gn:BSU02750" /db_xref="EnsemblGenomes-Tr:CAB12069" /db_xref="GOA:P46903" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11338" /db_xref="UniProtKB/Swiss-Prot:P46903" /translation="MITLTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGENGAGK TTMLRMIASLLEPSQGVITVDGFDTVKQPAEVKQRIGVLFGGETGLYDRMTAKENLQY FGRLYGLNRHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPDIIL FDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQALCDSVIMIHSGEVIYR GALESLYESERSEDLNYIFMSKLVRGIS*" /label="natA CDS" gene 276403..277143 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /label="natA gene" CDS 277144..278304 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10356997, 15849754, 16850406, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 15849754, 16850406, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (permease)" /protein_id="NP_388158.1" /db_xref="EnsemblGenomes-Gn:BSU02760" /db_xref="EnsemblGenomes-Tr:CAB12070" /db_xref="GOA:P46904" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11339" /db_xref="UniProtKB/Swiss-Prot:P46904" /translation="MLSHIYKKEMIDALRDRKTILLTILVPMIMMLGLVFFYESMLSD KGEQYTLAVGHSLPPALESKLNEIDEISVKTFAKPEEAVDEGKADAYLNVPKEFDSYV NSMTPFKVDVYGNSIDQGSSNAMQLVQSALDQYKNEIVQQRLTNKHIDQSVIQPFTIQ QKEADEEKGTSAIMLSAILPMLILTSIVSGAMPIALDIMAGEKDRKSIEALLLTPVSR NKVLVGKWLAVSTFGVASGVFALVFLILSTVLFTENLKTAFQLGDHMWSVIGASALII VLSALLISAMELFISIMSSSVKEAQSYMSLVVFLPVFPMFFIFSKAPNQFDLSYFLIP FLNLHALFKQLLFGMVDPATILSTSGTIAVLIAIFFLLARACFLKDKWVLPK*" /label="natB CDS" gene 277144..278304 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /label="natB gene" promotor_-35 278355..278363 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 278375..278393 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 278375 /Source="Nicolas_upshifts" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 278440..279372 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /EC_number="1.-.-.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322186, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ion channel associated aldo-keto reductase" /protein_id="NP_388159.1" /db_xref="EnsemblGenomes-Gn:BSU02770" /db_xref="EnsemblGenomes-Tr:CAB12071" /db_xref="GOA:P46905" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11340" /db_xref="UniProtKB/Swiss-Prot:P46905" /translation="MDQTRTLGKTKLKVKRIGFGANAVGGHNLFPNLNDETGKDLVRT ALDGGVNFIDTAFIYGLGRSEELIGEVVQERGVRNELIIATKGAHKEVDGSIELDNSR EFLRSEVEKSLKRLKTDYIDLYYVHFPDGKTPLAEVAGTLKELKDEGKIKAIGASNLD YQQLQDFNADGYLEVFQAEYSLIQRDAEKELLPYCEKQGISFIPYFPLASGLLTGKFT QDTVFDDFRKDKPQFQGETFIHNLKKVDKLKAVAEEKQADTAHVALAWLLTRPAIDAI IPGAKRPEQLQDNLKTLNIELTEDEVNFISDIFK*" /label="yccK CDS" gene 278440..279372 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /label="yccK gene" CDS complement(279412..280476) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 22496484; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in swarming behaviour" /protein_id="NP_388160.1" /db_xref="EnsemblGenomes-Gn:BSU02780" /db_xref="EnsemblGenomes-Tr:CAB12072" /db_xref="GOA:O34538" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="InterPro:IPR031343" /db_xref="PDB:4R4G" /db_xref="SubtiList:BG12757" /db_xref="UniProtKB/Swiss-Prot:O34538" /translation="MFQKKTYAVFLILLLMMFTAACSGSKTSAEKKESETEKSSDIAQ VKIKDVSYTLPSKYDKSTSDDQLVLKVNVAVKNTGKDPLNVDSMDFTLYQGDTKMSDT DPEDYSEKLQGSTINADKSVEGNLFFVVDKGKQYELNYTPESYGDKKPKSVTFKIDGK DKKILATADKLQDSAKALSAYVDVLLFGKDNADFEKITGANKNEIVNDFNESAKDGYL SASGLSSTYADSKALDNIVNGIKEGLSKNSSIQAKTTSISKDEAIVEATVKPVDASSL SDRIEDKVKDYYSKNSSASYEEAVKYALQVYPEEFKKLGPASSEKTVEVKMKKNDIDQ WQLDMDDYRAAELVEAFIKE*" /label="ycdA CDS" gene complement(279412..280476) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /label="ycdA gene" downshifts complement(279413) /Source="Nicolas_upshifts" /id="D114" /incds=0 /nref=198 /ntot=222 /MaxReadThrough="0.57029" /MaxDrop="8.85093" /score="27.0612397" /energy="-13.7" /TU="NA" /idTUdmin="U201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(280477..280667) /Source="Nicolas_S_feature" /locus_tag="new_300503_300693_c" /HighExp="S5, S4, MG 45, MG 15, MG-0.2, MG 25, MG-0.1, MG 10, S3, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S101" CDS complement(280499..280630) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513941.1" /translation="MTKEGGVSRKSGENREKRTDFFGYMMLIHSKRSISQRQKTPLS* " /label="hypothetical protein CDS" gene complement(280499..280630) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /label="gene" promotor_-10 complement(280652..280671) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(280672) /Source="Nicolas_upshifts" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(280686..280693) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 280804..282222 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388161.1" /db_xref="EnsemblGenomes-Gn:BSU02790" /db_xref="EnsemblGenomes-Tr:CAB12073" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12758" /db_xref="UniProtKB/Swiss-Prot:O34621" /translation="MKGAAFVKKEGLKQKALEIGRVPTHLKLEIEDYGGDDKRAHFCW ADPQDENTGIIVELGPDGELESLSRDIEPESGERLSEEKLEDIMRQFVETHHPGALSA FVREENDRAYGDKVRFSYVQMEAGLPLPMSGFMADVSLSGEIVYFRYYGEAGSIIKPK RVADVEEALAFIKKDVEFDLLFEVLHRSVYKNGDDQPHLVYEPEGRAITVPADLVQEE QAVDDDDDYREPESFPLPLFEGIREKADPDSMIGIENGFVKEREADLGDGRIGIVWRN PDDPVYQPADKSMDSWFKGRTHQVLKTIYNKETGKLEGVMSFMEKKGPLTVTLAECEK IALRFLFALFPNADQYFRIRYDEKDEEENAVAGFTFEAHCHGVPLRFGQIRICVSRQT GYITVYMGPDIDPNKLATIDPVPAISVEQAKSIFWQHFKVELGWEREYGDDEEHSYRL VYKPVYPHFIDAHTGEPVFSIW*" /label="ycdB CDS" gene 280804..282222 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /label="ycdB gene" promotor_-10 complement(282265..282283) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282273) /Source="Nicolas_upshifts" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(282297..282304) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 282329..282408 /Source="Nicolas_S_feature" /locus_tag="new_302355_302434" /HighExp="ferm, M40t45, M0t45, Lbstat, S0, nit, LBGtran, Lbtran, G135, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S102" upshifts 282329 /Source="Nicolas_upshifts" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="upshifts" promotor_-35 282331..282337 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-35" promotor_-10 282352..282369 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-10" CDS 282409..283770 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388162.1" /db_xref="EnsemblGenomes-Gn:BSU02800" /db_xref="EnsemblGenomes-Tr:CAB12074" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12759" /db_xref="UniProtKB/Swiss-Prot:O34772" /translation="MVNKQLKKKAQEIGNVPTHYELEIEDYDQKQKKYGQAYFIWKDP KDPEKHITVELRNDGALLTFSTTVHSETDKKLPDAELKLTALQFAAANHPGTFMNFHF QGKEERGQHIRFVYTKMELGLPIPNSGFLIDMTRSGQIVHFLYYGEGHKAEVPTEFVA KEKVVSHYLNTMSFELMYDVIDGEQEPRLVYEPILPGYSYPADVDEIVPDQHIADERI ENTAPLPPLQNKEEVDIFALLGFTSDMQKVSERDFGEQIGSTWRRGAAPERKDLSIGS YFETRNKNTIKMKTDKRTGKLKAALSFMDWRNNLQCSTEECQEIALQFLYALYPRAAE FFRVNPVRIDERGRVRNHFSVWYKGVPLRFGAARIIVNPETGLIDAFMAPDIEPEQLE AINHRPDVSAEEAKEAFLAAFDVKLEWQPDFTAGSDQHCKLVYKPVYPSYIDAHIRKK KRL*" /label="ycdC CDS" gene 282409..283770 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /label="ycdC gene" S_feature 283771..284351 /Source="Nicolas_S_feature" /locus_tag="new_303797_304377" /HighExp="ferm, M0t45, G135, G180, H2O2, M40t45, G150, Paraq, S0, nit" /AntisenseName="cwlK" /AntisenseCor="0.27553388443794402" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S103" CDS complement(283778..284281) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17588176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17588176; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="murein L,D:-endopeptidase" /protein_id="NP_388163.1" /db_xref="EnsemblGenomes-Gn:BSU02810" /db_xref="EnsemblGenomes-Tr:CAB12075" /db_xref="GOA:O34360" /db_xref="InterPro:IPR009045" /db_xref="SubtiList:BG12760" /db_xref="UniProtKB/Swiss-Prot:O34360" /translation="MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLH PIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYH NYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYP HLEMIPN*" /label="cwlK CDS" gene complement(283778..284281) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /label="cwlK gene" S_feature complement(284282..284363) /Source="Nicolas_S_feature" /locus_tag="new_304308_304389_c" /HighExp="Cold, T0.30H, LBGstat, C30, T-0.40H, T1.0H, T1.30H, H2O2, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S104" upshifts 284353 /Source="Nicolas_upshifts" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="upshifts" promotor_-10 complement(284355..284374) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 284356..284375 /Source="Nicolas_upshift_promotors" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(284364) /Source="Nicolas_upshifts" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="upshifts" CDS 284404..285525 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388164.1" /db_xref="EnsemblGenomes-Gn:BSU02820" /db_xref="EnsemblGenomes-Tr:CAB12076" /db_xref="GOA:O34327" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4GYO" /db_xref="SubtiList:BG12663" /db_xref="UniProtKB/Swiss-Prot:O34327" /translation="MRAKIPSEEVAVKLNEWYKLIRAFEADQAEALKQEIEYDLEDME ENQDLLLYFSLMEFRHRIMLDKLMPVKDSDTKPPFSDMLNEIESNQQKLTGLLEYYFY YFRGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQTYFSMN YASQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYM IAAAYYNVGHCKYSLGDYKEAEGYFKTAAAIFEEHNFQQAVQAVFSLTHIYCKEGKYD KAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAE DLLHDTAERFNQLEHYESAAFFYRRLMNIKKKLAEQRFQ*" /label="rapJ CDS" gene 284404..285525 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /label="rapJ gene" downshifts 285519 /Source="Nicolas_upshifts" /id="D115" /incds=0 /nref=88 /ntot=228 /MaxReadThrough="3.8438" /MaxDrop="5.06867" /score="32.2653577" /energy="-13.2" /TU="U204" /idTUdmin="U204" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 285566..285572 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 285587..285605 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 285590 /Source="Nicolas_upshifts" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 285632..286408 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388165.1" /db_xref="EnsemblGenomes-Gn:BSU02830" /db_xref="EnsemblGenomes-Tr:CAB12077" /db_xref="GOA:P80869" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12761" /db_xref="UniProtKB/Swiss-Prot:P80869" /translation="MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSG ADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMP HEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYS TSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAF GKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE*" /label="ycdF CDS" gene 285632..286408 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /label="ycdF gene" downshifts complement(285639) /Source="Nicolas_upshifts" /id="D116" /incds=0 /nref=10 /ntot=23 /MaxReadThrough="0.31912" /MaxDrop="4.8095" /score="0.506500496" /energy="-5.8" /TU="NA" /idTUdmin="U205" /TUdmin="-1914" /isTUend="FALSE" /label="downshifts" CDS 286433..288118 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-carbohydrate hydrolase" /protein_id="NP_388166.1" /db_xref="EnsemblGenomes-Gn:BSU02840" /db_xref="EnsemblGenomes-Tr:CAB12078" /db_xref="GOA:O34364" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12762" /db_xref="UniProtKB/Swiss-Prot:O34364" /translation="MKTDWWKDAVVYQIYPRSFQDSNGDGIGDLRGIISRLDYIKELG ADVIWICPIYPSPNVDYGYDVTNHKAIMDSYGTMDDFHELLDQVHQRGLKLVMDFVLN HTSVEHPWFKEAELDKNSKYRSYYYWRPGTKNGPPTDWLSNYGCPVWQYEEHTGEYYL HMNAVKQADLNWENPEVRQAVYDMMKFWLDKGVDGLRIDQLHLISKKEYLPSYEDYIN QQAEPKPFQPNGERIHDYLKEITDEVFSHYDVMSVGEVGSVTPEEGLKYTGTDKHELN MIFHFQHMELDQQPGKEHWDLKPLELSDLKSVLTKWQKKLEHQGWNTLFWCNHDQPRI VSRFGDDGEYRKASAKMLAAVIYFMKGTPYIYQGEEIGMTNAPFTRIEDYKDIQTINM YHKRVFEKGYDPNDVMRSILAKSRDHARTPMQWNSGKNAGFTDGTPWLKVNPNFTAIN VEEAQGDPDSVLNYYKKLISLRKQYADLMKGSFDLLLPDDPQLFVYMRENSKQQLLSV NNFSKEQAVFQWPKNCGKAQASLLLSNYNNDDLDDEMVFRPYESRVYLLDKTN*" /label="ycdG CDS" gene 286433..288118 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /label="ycdG gene" promotor_no_box 287373..287473 /Source="Nicolas_upshift_promotors" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 287433 /Source="Nicolas_upshifts" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 287499 /Source="Nicolas_upshifts" /id="D117" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.77365" /MaxDrop="2.18547" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=1914 /isTUend="FALSE" /label="downshifts" downshifts 288115 /Source="Nicolas_upshifts" /id="D118" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="5.8252" /MaxDrop="5.18702" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" promotor_-35 288209..288216 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 288232..288251 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 288238 /Source="Nicolas_upshifts" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 288306..289265 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9379902, 12426338, 14730579, 21813502; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="Zn(II)-binding lipoprotein" /protein_id="NP_388167.1" /db_xref="EnsemblGenomes-Gn:BSU02850" /db_xref="EnsemblGenomes-Tr:CAB12079" /db_xref="GOA:O34966" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="PDB:2O1E" /db_xref="SubtiList:BG12763" /db_xref="UniProtKB/Swiss-Prot:O34966" /translation="MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFY PMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPS AEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEV KNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYL AKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEI GAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS*" /label="znuA CDS" gene 288306..289265 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /label="znuA gene" promotor_-35 288861..288867 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 288881..288900 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 288885 /Source="Nicolas_upshifts" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" downshifts 289237 /Source="Nicolas_upshifts" /id="D119" /incds=0 /nref=140 /ntot=250 /MaxReadThrough="6.07181" /MaxDrop="5.15011" /score="8.99106569" /energy="-15.9" /TU="U206,U208,U209" /idTUdmin="U206" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS 289321..290016 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Zn(II) transporter (ATP-binding protein)" /protein_id="NP_388168.1" /db_xref="EnsemblGenomes-Gn:BSU02860" /db_xref="EnsemblGenomes-Tr:CAB12080" /db_xref="GOA:O34946" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12764" /db_xref="UniProtKB/Swiss-Prot:O34946" /translation="MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKST LIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYT KGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLM LDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGG WKCLTWNSCDELF*" /label="znuC CDS" gene 289321..290016 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /label="znuC gene" CDS 289974..290816 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity Zn(II) ABC transporter (permease)" /protein_id="NP_388169.1" /db_xref="EnsemblGenomes-Gn:BSU02870" /db_xref="EnsemblGenomes-Tr:CAB12081" /db_xref="GOA:O34610" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12765" /db_xref="UniProtKB/Swiss-Prot:O34610" /translation="MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSH ISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAM FLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDE ATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMV FITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRK KRSR*" /label="znuB CDS" gene 289974..290816 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /label="znuB gene" downshifts 290803 /Source="Nicolas_upshifts" /id="D120" /incds=0 /nref=168 /ntot=266 /MaxReadThrough="2.4865" /MaxDrop="6.44929" /score="27.8218406" /energy="-13.6" /TU="NA" /idTUdmin="U206" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(290854..291849) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16428414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative luciferase-like monooxygenase" /protein_id="NP_388170.2" /db_xref="EnsemblGenomes-Gn:BSU02880" /db_xref="EnsemblGenomes-Tr:CAB12082" /db_xref="GOA:O34504" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12766" /db_xref="UniProtKB/Swiss-Prot:O34504" /translation="MIHLSILDQAPVSKGESPVTTLQHSVELAQLSEQWGYKRYWFAE HHSTKGLASTAPEIMIARIAAQTNTIRVGSGGVLLPQYSPFKVAETFRQLEALYPNRI DLGVGRSPGGTTKTRLALTDGVKKSLTEFNRQLQDVSYFLTDSLPPDHPYAGIKAAPL IGTAPELWVLGLGENSARRAAHQGIGYVFGHFINPERGENAFRIYRESFRPSAHFSNP SALFTIFVICAKTDEEAEELALSQDLWLLRVGKGLDSRVPSIEEAKAHPYTASDKKLI EENRKRMVIGSPTTVKQQLLDLTGCYETNEIMVLCNVFDFEAKKESYERLAELFL*" /label="yceB CDS" gene complement(290854..291849) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /label="yceB gene" promotor_-35 291805..291812 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-35" promotor_-10 291827..291846 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-10" S_feature 291833..292035 /Source="Nicolas_S_feature" /locus_tag="new_311859_312061" /HighExp="Diami, Etha, dia5, Salt, H2O2, dia15, Paraq, T-0.40H, T0.30H, G135" /AntisenseName="yceB" /AntisenseCor="0.84300534435872998" /AntisenseRegPval="-73.099999999999994" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S105" upshifts 291833 /Source="Nicolas_upshifts" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="upshifts" promotor_-10 complement(291881..291900) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(291889) /Source="Nicolas_upshifts" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(291915..291922) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 292019..292028 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 292037..292132 /Source="Nicolas_S_feature" /locus_tag="new_312063_312158" /HighExp="T0.0H, T-0.40H, T-1.10H, T0.30H, Salt, T1.0H, Etha, T-1.40H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S106" upshifts 292037 /Source="Nicolas_upshifts" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 292041..292056 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 292133..292732 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388171.1" /db_xref="EnsemblGenomes-Gn:BSU02890" /db_xref="EnsemblGenomes-Tr:CAB12083" /db_xref="GOA:P81100" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12767" /db_xref="UniProtKB/Swiss-Prot:P81100" /translation="MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLG GGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIM IDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYA GRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV*" /label="yceC CDS" gene 292133..292732 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /label="yceC gene" CDS 292754..293335 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388172.1" /db_xref="EnsemblGenomes-Gn:BSU02900" /db_xref="EnsemblGenomes-Tr:CAB12084" /db_xref="GOA:P80875" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12768" /db_xref="UniProtKB/Swiss-Prot:P80875" /translation="MTISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDS SVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHSGDNLTGAGEGDDENVKVNLSAVPAN IDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSIETAIIAGE LYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG*" /label="yceD CDS" gene 292754..293335 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /label="yceD gene" CDS 293370..293948 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388173.1" /db_xref="EnsemblGenomes-Gn:BSU02910" /db_xref="EnsemblGenomes-Tr:CAB12085" /db_xref="GOA:O34384" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12769" /db_xref="UniProtKB/Swiss-Prot:O34384" /translation="MAIQLSKGQRIDLTKTNPGLTKAVIGLGWDTNKYSGGHDFDLDA SAFLVDAHDNCVNDLDFVFYNNLEHPSGGVIHTGDNRTGEGDGDDEQIIVDFSKIPAH IEKIGITVTIHDAEARSQNFGQVSNAFVRVVDEETQNELLRFDLGEDFSIETAVVVCE LYRHGGEWKFNAIGSGFSGGLAALCRNYGLQV*" /label="yceE CDS" gene 293370..293948 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /label="yceE gene" CDS 293999..294772 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 24366250; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative stress adaptation transporter (tellurite resistance)" /protein_id="NP_388174.1" /db_xref="EnsemblGenomes-Gn:BSU02920" /db_xref="EnsemblGenomes-Tr:CAB12086" /db_xref="GOA:O34447" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="SubtiList:BG12770" /db_xref="UniProtKB/Swiss-Prot:O34447" /translation="MDFLHHILSTYASFFDWKMWGEVLTDPVSWGLIGSLVVLEGLLS ADNALVLAVMVKHLPEKQRKKALTYGLFGAYIFRFIFIGLGMLLIKFWWIKVLGALYL AWLVIKHFWIGEKEEEADGMKKNSWMVRTFGIFWATVISVELMDLAFSVDSILAAFAV SEKVWVLLIGGMLGILMMRTVAKVFLVLIDKIPELENTAFVLIGIIALKMAGSAFHYE MPHSVFFIIIIAAFAVTLIIHYINKQKQVREQTAASKEE*" /label="yceF CDS" gene 293999..294772 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /label="yceF gene" downshifts 294759 /Source="Nicolas_upshifts" /id="D121" /incds=0 /nref=46 /ntot=239 /MaxReadThrough="6.82513" /MaxDrop="4.0674" /score="4.0495978" /energy="-8.2" /TU="U212" /idTUdmin="U210" /TUdmin=2728 /isTUend="FALSE" /label="downshifts" CDS 294857..296470 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxic compound adaptation protein (tellurite resistance)" /protein_id="NP_388175.1" /db_xref="EnsemblGenomes-Gn:BSU02930" /db_xref="EnsemblGenomes-Tr:CAB12087" /db_xref="InterPro:IPR025647" /db_xref="SubtiList:BG12771" /db_xref="UniProtKB/Swiss-Prot:O34809" /translation="MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRLA GQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGL SVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDV SKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQ LALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYRSTKEIEHVLNHEESMLYKP WQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNK EYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQY KQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFD YAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEEDQYD IHWLDDMVFQQDYKEPSLVKRLFRTITQK*" /label="yceG CDS" gene 294857..296470 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /label="yceG gene" CDS 296486..297577 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative reactive oxygen species resistance protein" /protein_id="NP_388176.1" /db_xref="EnsemblGenomes-Gn:BSU02940" /db_xref="EnsemblGenomes-Tr:CAB12088" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG12772" /db_xref="UniProtKB/Swiss-Prot:O34833" /translation="MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDV KNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEP KGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNI KYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYD LDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVAD SMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQI EEENKRLREDGARRIAQLQDNIKKAALQQ*" /label="yceH CDS" gene 296486..297577 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /label="yceH gene" downshifts 297551 /Source="Nicolas_upshifts" /id="D122" /incds=0 /nref=85 /ntot=228 /MaxReadThrough="4.46836" /MaxDrop="4.05585" /score="-6.59172775" /energy="-17.5" /TU="U212" /idTUdmin="U212" /TUdmin="-1322" /isTUend="FALSE" /label="downshifts" promotor_-35 297631..297638 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 297653..297672 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 297661 /Source="Nicolas_upshifts" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="upshifts" CDS 297699..298901 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18276644, 21953179" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18276644, 21953179; Product type t: transporter" /codon_start=1 /transl_table=11 /product="niacin permease" /protein_id="NP_388177.1" /db_xref="EnsemblGenomes-Gn:BSU02950" /db_xref="EnsemblGenomes-Tr:CAB12089" /db_xref="GOA:O34691" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12773" /db_xref="UniProtKB/Swiss-Prot:O34691" /translation="MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLS PEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAF LILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP SFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTV MLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEK AGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPT AIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGK ETKQTELE*" /label="niaP CDS" gene 297699..298901 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /label="niaP gene" downshifts 298881 /Source="Nicolas_upshifts" /id="D123" /incds=0 /nref=8 /ntot=184 /MaxReadThrough="4.1968" /MaxDrop="3.48367" /score="13.0427769" /energy="-10.6" /TU="U213" /idTUdmin="U212" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(299154..300326) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate transporter (possibly exporter)" /protein_id="NP_388178.1" /db_xref="EnsemblGenomes-Gn:BSU02960" /db_xref="EnsemblGenomes-Tr:CAB12090" /db_xref="GOA:O34724" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12774" /db_xref="UniProtKB/Swiss-Prot:O34724" /translation="MNRIWLFFSVMFVIGTDTFLLSPLLPLLQDQFHVSTDLSGWMVS AYALGYALFAFIAGPISDRLNRKTVMLWGLAGFIVSTFLCGIAPSFAAMCLFRFAAGV SAAFVTPQIWASIPVIVQPSQIIKGMGIATAGLAASQMLGLPIGGFLASFTWHTPFFV LSACSLILLLILAAVMPGIRPSEPLARPSIVNPYRELFSLPKTSVILLAYFLFQTGNF ASFSFLGTWLSADYHLTVSQIGAAMLVLGLGNMLGSLIGSRVSEKLGMFKTLISGMLL MGALYFALPFFPNLFLVEAGFFLTFFTAGIIFPLMMGVFQSIAPNARGTIASLSNAAM YAGTTVGTSIAGFLYQSTQHFGAVTGFTAILFILSMTLYQTISKTGKRQSTARAQL*" /label="yceJ CDS" gene complement(299154..300326) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /label="yceJ gene" downshifts complement(299169) /Source="Nicolas_upshifts" /id="D124" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="2.6211" /MaxDrop="2.7452" /score="9.21991741" /energy="-12.6" /TU="NA" /idTUdmin="U214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(300395..300697) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388179.1" /db_xref="EnsemblGenomes-Gn:BSU02970" /db_xref="EnsemblGenomes-Tr:CAB12091" /db_xref="GOA:O34464" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12775" /db_xref="UniProtKB/Swiss-Prot:O34464" /translation="MYYSFMTMKQSDDQIRAQIFKALSDESRLAIIRTLYVSGKELSC GEVGEKCNIVKTTASYHFKTLREAGLTATRKDSRTKYVSLREDTFQTYLPGFLETL*" /label="yceK CDS" gene complement(300395..300697) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /label="yceK gene" downshifts complement(300423) /Source="Nicolas_upshifts" /id="D125" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="5.67096" /MaxDrop="6.89889" /score="2.01231069" /energy="-4.8" /TU="U214" /idTUdmin="U214" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(300680..300699) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(300699) /Source="Nicolas_upshifts" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(300713..300719) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 300946..300965 /Source="Nicolas_upshift_promotors" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 300946 /Source="Nicolas_upshifts" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="upshifts" CDS 300987..302243 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(ATP-binding protein)" /protein_id="NP_388180.2" /db_xref="EnsemblGenomes-Gn:BSU02980" /db_xref="EnsemblGenomes-Tr:CAB12092" /db_xref="GOA:P46920" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11370" /db_xref="UniProtKB/Swiss-Prot:P46920" /translation="MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATG STVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSK DQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLE GFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDN VGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLS KVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAA ESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGA LAGNNEYINAEGTNEQTQDPSAQEVK*" /label="opuAA CDS" gene 300987..302243 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /label="opuAA gene" downshifts complement(300995) /Source="Nicolas_upshifts" /id="D126" /incds=0 /nref=108 /ntot=175 /MaxReadThrough="2.83797" /MaxDrop="5.18503" /score="2.01231069" /energy="-4.8" /TU="NA" /idTUdmin="U214" /TUdmin="-1826" /isTUend="FALSE" /label="downshifts" CDS 302245..303093 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752321, 15849754, 16225868, 16645306, 16850406, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752321, 15849754, 16225868, 16645306, 16850406, 25012968; Product type t : transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(permease)" /protein_id="NP_388181.1" /db_xref="EnsemblGenomes-Gn:BSU02990" /db_xref="EnsemblGenomes-Tr:CAB12093" /db_xref="GOA:P46921" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11371" /db_xref="UniProtKB/Swiss-Prot:P46921" /translation="MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVT GLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVI ISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASV IFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIM LALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKK KSRGNA*" /label="opuAB CDS" gene 302245..303093 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /label="opuAB gene" CDS 303093..303974 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporterABC transporter (glycine betaine-binding lipoprotein)" /protein_id="NP_388182.1" /db_xref="EnsemblGenomes-Gn:BSU03000" /db_xref="EnsemblGenomes-Tr:CAB12094" /db_xref="GOA:P46922" /db_xref="InterPro:IPR007210" /db_xref="PDB:2B4L" /db_xref="PDB:2B4M" /db_xref="PDB:3CHG" /db_xref="SubtiList:BG11372" /db_xref="UniProtKB/Swiss-Prot:P46922" /translation="MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDP GSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRY KLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGE KPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGY EVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGL VVPQYMKNVNSIEDLKK*" /label="opuAC CDS" gene 303093..303974 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /label="opuAC gene" downshifts 303955 /Source="Nicolas_upshifts" /id="D127" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="0.74967" /MaxDrop="8.21394" /score="33.6263027" /energy="-12.2" /TU="NA" /idTUdmin="U215" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(303987) /Source="Nicolas_upshifts" /id="D128" /incds=0 /nref=2 /ntot=62 /MaxReadThrough="4.29566" /MaxDrop="3.9514" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(304012..305163) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8768514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388183.2" /db_xref="EnsemblGenomes-Gn:BSU03010" /db_xref="EnsemblGenomes-Tr:CAB12095" /db_xref="GOA:P54983" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11789" /db_xref="UniProtKB/Swiss-Prot:P54983" /translation="MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLG CRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGT LMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNG RCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTV KMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELH KEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTML GLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS*" /label="amhX CDS" gene complement(304012..305163) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /label="amhX gene" downshifts complement(304031) /Source="Nicolas_upshifts" /id="D129" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="4.33606" /MaxDrop="3.5225" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" S_feature complement(305164..305251) /Source="Nicolas_S_feature" /locus_tag="new_325190_325277_c" /HighExp="Etha, T1.30H, M9-stat, T2.30H, S1, T3.30H, T5.0H, T4.0H, Sw, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S107" promotor_-35 305219..305226 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-35" promotor_-10 complement(305238..305257) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 305241..305260 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-10" upshifts complement(305251) /Source="Nicolas_upshifts" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="upshifts" upshifts 305254 /Source="Nicolas_upshifts" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="upshifts" promotor_-35 complement(305270..305276) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 305313..306746 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21747963, 21764931; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative branched chain amino acid permease" /protein_id="NP_388184.2" /db_xref="EnsemblGenomes-Gn:BSU03020" /db_xref="EnsemblGenomes-Tr:CAB12096" /db_xref="GOA:P55908" /db_xref="InterPro:IPR018385" /db_xref="SubtiList:BG11999" /db_xref="UniProtKB/Swiss-Prot:P55908" /translation="MSMPAAETQPKKKRMTFKMPDAYVLLFMIAFICAIASYIVPAGE FDRVTKGDVTTAVPGSYHSIEQSPVRLISFFTSLQDGMVGSAPIIFLILFTGGTIAIL EKTGAINGLIYNVISKFRTKQLLFICIVGALFSILGTTGIVVNSVIGFIPIGLIVARS LKWDAVAGAAVIYIGCYAGFNSTILSPSPLGLSQSIAELPLFSGIGLRVVIYICFLLS SIIYIYLYTRKLKKSKDASVLGTDWFPAAGMGEAGKEEDQSVPFTVRHKLILAVAGLS LVGFLYGALKLGWSDSQMAATFIFISVLAGLIGGLAANDIAKTFITGCQSLVYGALIV GMARSISVILENGKLLDTVVNALASLLDGFSPIAGAIGMYIASALLHFLISSGSGEAV VFIPILAPLADLMGITRQVAVEAVMLGEGVVNCVNPTSGVLMAVLAASGIPYVKWLRF MVPLALIWFLIGLVFIVIGVMINWGPF*" /label="ycgA CDS" gene 305313..306746 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /label="ycgA gene" promotor_-35 306051..306059 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 306071..306089 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 306090 /Source="Nicolas_upshifts" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 306728 /Source="Nicolas_upshifts" /id="D130" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="3.53497" /MaxDrop="3.31444" /score="12.0135493" /energy="-15.6" /TU="U217" /idTUdmin="U218" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 306789..306796 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 306811..306830 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 306820 /Source="Nicolas_upshifts" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 306862..307443 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406, 22720735; Producttype m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_388185.2" /db_xref="EnsemblGenomes-Gn:BSU03030" /db_xref="EnsemblGenomes-Tr:CAB12097" /db_xref="SubtiList:BG12000" /db_xref="UniProtKB/Swiss-Prot:P55909" /translation="MNNLRNRLSGVNGKNKRVKEKEQKIWSEIGMIAGAFALLDVIIR GIMFEFPFKEWAASLVFLFIIILYYCIRAAASGMLMPRIDTKEELQKRVKQQRIESIA VAFAVVVLTMYDRGIPHTFFAWLKMILLFIVCGGVLFLLRYVIVKLAYRRAVKEEIKK KSSFLFGKRGKRSQFRAAFFIGTLICIHSAKLF*" /label="ycgB CDS" gene 306862..307443 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /label="ycgB gene" upshifts 307256 /Source="Nicolas_upshifts" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" misc_feature 307260..307264 /Source="Nicolas_upshift_promotors" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 307419..307426 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 307441..307460 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 307454..307591 /Source="Nicolas_S_feature" /locus_tag="new_327480_327617" /HighExp="BC, M0t90, M40t90, S2, M9-stat, T4.0H, Sw, T3.30H, Lbtran, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.999, 0.242, 0.999" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S108" upshifts 307454 /Source="Nicolas_upshifts" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 307592..309571 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /EC_number="3.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3117969, 9353930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3117969, 9353930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-amylase" /protein_id="NP_388186.2" /db_xref="EnsemblGenomes-Gn:BSU03040" /db_xref="EnsemblGenomes-Tr:CAB12098" /db_xref="GOA:P00691" /db_xref="InterPro:IPR006046" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR031319" /db_xref="InterPro:IPR031965" /db_xref="PDB:1BAG" /db_xref="PDB:1UA7" /db_xref="SubtiList:BG10473" /db_xref="UniProtKB/Swiss-Prot:P00691" /translation="MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTA PSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWL YQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPN WTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDA AKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSI RSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVI ASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEE LSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGK LTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQI NNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIG YQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVI FNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH*" /label="amyE CDS" gene 307592..309571 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /label="amyE gene" downshifts 309585 /Source="Nicolas_upshifts" /id="D131" /incds=0 /nref=57 /ntot=131 /MaxReadThrough="1.64783" /MaxDrop="6.55823" /score="-8.82332571" /energy="-3.4" /TU="U221" /idTUdmin="U219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 309651..309658 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 309668 /Source="Nicolas_upshifts" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 309672..309691 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 309748..310713 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /EC_number="1.1.1.27" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10809684, 16207915, 19383131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 16207915, 19383131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lactate dehydrogenase" /protein_id="NP_388187.2" /db_xref="EnsemblGenomes-Gn:BSU03050" /db_xref="EnsemblGenomes-Tr:CAB12099" /db_xref="GOA:P13714" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011304" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR018177" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="PDB:3PQD" /db_xref="PDB:3PQE" /db_xref="PDB:3PQF" /db_xref="SubtiList:BG19003" /db_xref="UniProtKB/Swiss-Prot:P13714" /translation="MMNKHVNKVALIGAGFVGSSYAFALINQGITDELVVIDVNKEKA MGDVMDLNHGKAFAPQPVKTSYGTYEDCKDADIVCICAGANQKPGETRLELVEKNLKI FKGIVSEVMASGFDGIFLVATNPVDILTYATWKFSGLPKERVIGSGTTLDSARFRFML SEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEKNDAYKQEELDQIVDD VKNAAYHIIEKKGATYYGVAMSLARITKAILHNENSILTVSTYLDGQYGADDVYIGVP AVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILKPHFAEQKVN*" /label="lctE CDS" gene 309748..310713 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /label="lctE gene" CDS 310745..312370 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10809684, 15849754, 16428414, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 15849754, 16428414, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_388188.2" /db_xref="EnsemblGenomes-Gn:BSU03060" /db_xref="EnsemblGenomes-Tr:CAB12100" /db_xref="GOA:P55910" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG12001" /db_xref="UniProtKB/Swiss-Prot:P55910" /translation="MWEQLYDPFGNEYVSALVALTPILFFLLALTVLKMKGILAAFLT LAVSFFVSVWAFHMPVEKAISSVLLGIGSGLWPIGYIVLMAVWLYKIAVKTGKFTIIR SSIAGISPDQRLQLLLIGFCFNAFLEGAAGFGVPIAISAALLVELGFKPLKAAALCLI ANAASGAFGAIGIPVITGAQIGDLSALELSRTLMWTLPMISFLIPFLLVFLLDRMKGI KQTWPALLVVSGGYTAVQTLTMAVLGPELANILAALFSMGGLALFLRKWQPKEIYREE GAGDAGEKKAYRAADIAKAWSPFYILTAAITIWSLPAFKALFQEGGLLYQSTLLFKMP FLHQQIMKMPPIAPSAMPLDAVFKVDLLSATGTAILAAVIVTGLFSKKFSSRDAFASL KETGKELWVPIMTICFVMGFANLANFAGLSSSIGLALAKTGDLFPFVSPVLGWIGVFI TGSVVSNNALFGHLQVVTGAQIGAGSDLLLAANTAGGVMAKLVSPQSIAIAAAAVGQT GKESKLFKRTVAYSLILLLIICIWTFILARLGV*" /label="lctP CDS" gene 310745..312370 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /label="lctP gene" downshifts 310751 /Source="Nicolas_upshifts" /id="D132" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="8.56142" /MaxDrop="2.8862" /score="-8.82332571" /energy="-3.4" /TU="U222" /idTUdmin="U221" /TUdmin=1144 /isTUend="FALSE" /label="downshifts" downshifts 312357 /Source="Nicolas_upshifts" /id="D133" /incds=0 /nref=51 /ntot=118 /MaxReadThrough="2.31168" /MaxDrop="7.73065" /score="39.575264" /energy="-15.6" /TU="NA" /idTUdmin="U222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(312415..313953) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9023234, 15489457, 15849754, 16850406, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023234, 15489457, 15849754, 16850406, 21690368; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_388189.2" /db_xref="EnsemblGenomes-Gn:BSU03070" /db_xref="EnsemblGenomes-Tr:CAB12101" /db_xref="GOA:P96712" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12002" /db_xref="UniProtKB/Swiss-Prot:P96712" /translation="MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLG SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQ LIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIIT DSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALE LGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFL YGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLM LISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRG TANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEI FQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMT KKAN*" /label="mdr CDS" gene complement(312415..313953) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /label="mdr gene" downshifts complement(312433) /Source="Nicolas_upshifts" /id="D134" /incds=0 /nref=70 /ntot=182 /MaxReadThrough="1.04964" /MaxDrop="4.53635" /score="30.8374042" /energy="-15.6" /TU="NA" /idTUdmin="U225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(313007..313107) /Source="Nicolas_upshift_promotors" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(313047) /Source="Nicolas_upshifts" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 313967..313971 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 313987..314006 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 314001 /Source="Nicolas_upshifts" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(314033..314052) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(314036) /Source="Nicolas_upshifts" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="upshifts" CDS 314066..314530 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388190.2" /db_xref="EnsemblGenomes-Gn:BSU03080" /db_xref="EnsemblGenomes-Tr:CAB12102" /db_xref="GOA:O31472" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12003" /db_xref="UniProtKB/Swiss-Prot:O31472" /translation="MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQALGLFPTDLK SADILNEAGPMTAGELGKKTGLSTGSVTALVDRLEKAGYVAREKDPNDRRRVVIVPLT ASKKHIKDLFRPLSESTMDLCREYTEEELELIFSFVGKAADIMEEELERLKQ*" /label="ycgE CDS" gene 314066..314530 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /label="ycgE gene" promotor_-35 complement(314067..314073) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 314540..314545 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 314561..314579 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 314571 /Source="Nicolas_upshifts" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 314604..315233 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid export permease" /protein_id="NP_388191.1" /db_xref="EnsemblGenomes-Gn:BSU03090" /db_xref="EnsemblGenomes-Tr:CAB12103" /db_xref="GOA:P94381" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG12004" /db_xref="UniProtKB/Swiss-Prot:P94381" /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGA MTADGLYMLFIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGIETLKNVREPMDVRSSRG KPSYRKTFASGFLISLSNPLSILFWLGIYGSILAKTAEAYNMNQLLIYSSGIMIGILI WDFCMAITASTFRNLLHEKLLRGLTGIAGVSLLVFGFYFGYQGIKQLLG*" /label="ycgF CDS" gene 314604..315233 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /label="ycgF gene" promotor_-35 315244..315253 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 315267..315286 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 315275 /Source="Nicolas_upshifts" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 315303..316064 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (similar to phage protein)" /protein_id="NP_388192.2" /db_xref="EnsemblGenomes-Gn:BSU03100" /db_xref="EnsemblGenomes-Tr:CAB12104" /db_xref="InterPro:IPR014988" /db_xref="SubtiList:BG12005" /db_xref="UniProtKB/Swiss-Prot:P94382" /translation="MVNGIYTKSFLERIQEELPEWQRIAFELLAETLGDDADTFPCIP GRQAFLTDQLRIAFAGDPRENRTAEELAPLLAEYGKISRDTGKYASLVVLFDTPEDLA EHYSIEAYEELFWRFLNRLSHQDEKEWPEDIPADPEHYKWEFCFDGEPYFILCATPGH EARRSRSFPFFMVTFQPRWVFDDLNGSTAFGRNMSRLIRSRLEAYDQAPIHPQLGWYG GKDNREWKQYFLRDDEKQVSKCPFSYLKNMFNKMK*" /label="ycgG CDS" gene 315303..316064 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /label="ycgG gene" S_feature complement(315703..316065) /Source="Nicolas_S_feature" /locus_tag="new_335729_336091_c" /HighExp="S8, S7, S5, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="ycgG" /AntisenseCor="0.73875580854115197" /AntisenseRegPval="-46.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S109" downshifts 316061 /Source="Nicolas_upshifts" /id="D135" /incds=0 /nref=21 /ntot=174 /MaxReadThrough="1.53211" /MaxDrop="4.92685" /score="6.36985882" /energy="-8.6" /TU="NA" /idTUdmin="U227" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(316066..317406) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid transporter" /protein_id="NP_388193.2" /db_xref="EnsemblGenomes-Gn:BSU03110" /db_xref="EnsemblGenomes-Tr:CAB12105" /db_xref="GOA:P94383" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12006" /db_xref="UniProtKB/Swiss-Prot:P94383" /translation="MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGF SVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEM LITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTA AIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVM GLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGY NLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPAL GLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQI YLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP*" /label="ycgH CDS" gene complement(316066..317406) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /label="ycgH gene" promotor_-10 complement(317433..317444) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(317443) /Source="Nicolas_upshifts" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(317459..317465) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 317485..317491 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 317499 /Source="Nicolas_upshifts" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 317506..317517 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 317536..318132 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16433904, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388194.3" /db_xref="EnsemblGenomes-Gn:BSU03120" /db_xref="EnsemblGenomes-Tr:CAB12106" /db_xref="InterPro:IPR018959" /db_xref="SubtiList:BG12007" /db_xref="UniProtKB/Swiss-Prot:O31473" /translation="MTQQYIVEPKKGLGLKLKKGQILKVVDVEGQQVADFVAYHAKDF YEHLDQGATIDANHSIHVKVNDHLYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLL YGKQKDEFQDTCYDNMNRALEQFGVPKPHMHYPFAIFMNTVLDEKGNLSVETPLSNAG DYVRLRAEMDLIVAFSSCPIEKGKCNGDSVTSIRVEVS*" /label="ycgI CDS" gene 317536..318132 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /label="ycgI gene" promotor_-35 318140..318147 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 318161..318261 /Source="Nicolas_S_feature" /locus_tag="new_338187_338287" /HighExp="dia15, LBGtran, dia5, Etha, dia0, LBGexp, M0t45, Lbexp, Diami, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S110" promotor_-10 318161..318180 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 318161 /Source="Nicolas_upshifts" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(318257) /Source="Nicolas_upshifts" /id="D136" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="1.2989" /MaxDrop="4.67402" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS 318262..319080 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /EC_number="6.3.1.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7890752, 9271869, 12682299, 19204287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7890752, 9271869, 12682299, 19204287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ammonium-dependent NAD+ synthetase" /protein_id="NP_388195.1" /db_xref="EnsemblGenomes-Gn:BSU03130" /db_xref="EnsemblGenomes-Tr:CAB12107" /db_xref="GOA:P08164" /db_xref="InterPro:IPR003694" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022926" /db_xref="PDB:1EE1" /db_xref="PDB:1FYD" /db_xref="PDB:1IFX" /db_xref="PDB:1IH8" /db_xref="PDB:1KQP" /db_xref="PDB:1NSY" /db_xref="PDB:2NSY" /db_xref="SubtiList:BG10694" /db_xref="UniProtKB/Swiss-Prot:P08164" /translation="MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVL GISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDK SWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDH AAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQ QSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK*" /label="nadE CDS" gene 318262..319080 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /label="nadE gene" downshifts 319062 /Source="Nicolas_upshifts" /id="D137" /incds=0 /nref=144 /ntot=271 /MaxReadThrough="2.68866" /MaxDrop="6.24927" /score="20.6612287" /energy="-14.1" /TU="U230" /idTUdmin="U230" /TUdmin="-65" /isTUend="FALSE" /label="downshifts" CDS complement(319130..319723) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1624425, 7766032, 15131133, 27315722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624425, 7766032, 15131133, 27315722; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATP-binding tunicamycin resistance protein" /protein_id="NP_388196.2" /db_xref="EnsemblGenomes-Gn:BSU03140" /db_xref="EnsemblGenomes-Tr:CAB12108" /db_xref="GOA:P12921" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10456" /db_xref="UniProtKB/Swiss-Prot:P12921" /translation="MIIWINGAFGSGKTQTAFELHRRLNPSYVYDPEKMGFALRSMVP QEIAKDDFQSYPLWRAFNYSLLASLTDTYRGILIVPMTIVHPEYFNEIIGRLRQEGRI VHHFTLMASKETLLKRLRTRAEGKNSWAAKQIDRCVEGLSSPIFEDHIQTDNLSIQDV AENIAARAELPLDPDTRGSLRRFADRLMVKLNHIRIK*" /label="tmrB CDS" gene complement(319130..319723) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /label="tmrB gene" downshifts complement(319137) /Source="Nicolas_upshifts" /id="D138" /incds=0 /nref=10 /ntot=143 /MaxReadThrough="0.60282" /MaxDrop="3.74815" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(319738..319757) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(319753) /Source="Nicolas_upshifts" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(319772..319775) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(319781..319929) /Source="Nicolas_S_feature" /locus_tag="new_339807_339955_c" /HighExp="S4, S3, S6, S5, S7, BT, S8, LoTm, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S111" promotor_-35 319831..319838 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 319851..319870 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 319853..319961 /Source="Nicolas_S_feature" /locus_tag="new_339879_339987" /HighExp="Diami, BMM, GM 15, GM 25, GM 120, GM 60, GM 10, G180, GM 45, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S112" upshifts 319855 /Source="Nicolas_upshifts" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(319923..319941) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 319929..319936 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(319939) /Source="Nicolas_upshifts" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 319951..319970 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(319957..319962) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 319963 /Source="Nicolas_upshifts" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="upshifts" CDS 319999..320559 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /EC_number="2.7.1.71" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 170268, 7612934, 27339308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate kinase" /protein_id="NP_388197.2" /db_xref="EnsemblGenomes-Gn:BSU03150" /db_xref="EnsemblGenomes-Tr:CAB12109" /db_xref="GOA:P37944" /db_xref="InterPro:IPR000623" /db_xref="InterPro:IPR023000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031322" /db_xref="SubtiList:BG10457" /db_xref="UniProtKB/Swiss-Prot:P37944" /translation="MNAKRAIPVRERNIVLIGFMGVGKTTIGQLVAKKLYRDFIDIDQ QIEKDFNMSIPEIFEKKGEDFFRKTEKEYILDICHHKRFKIVSLGGGSFKQEEIRNCC LENCLVLHLDLSWENWKQRADLLIESRPVLHNRSMDEMEQLFNERKVIYDKHNSKVAT DNLSPEEVADYIVETLKIGWDLYQPM*" /label="aroK CDS" gene 319999..320559 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /label="aroK gene" downshifts 320536 /Source="Nicolas_upshifts" /id="D139" /incds=0 /nref=21 /ntot=239 /MaxReadThrough="2.07607" /MaxDrop="4.67156" /score="44.9099474" /energy="-13.1" /TU="NA" /idTUdmin="U232" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(320587..321348) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388198.2" /db_xref="EnsemblGenomes-Gn:BSU03160" /db_xref="EnsemblGenomes-Tr:CAB12110" /db_xref="GOA:O31474" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XXL" /db_xref="PDB:2GLU" /db_xref="SubtiList:BG12008" /db_xref="UniProtKB/Swiss-Prot:O31474" /translation="MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDI GAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDD SFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLR DPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLN HASDEARDTFCITLNQNGQPISFCLKAILIQGIKR*" /label="ycgJ CDS" gene complement(320587..321348) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /label="ycgJ gene" downshifts complement(320611) /Source="Nicolas_upshifts" /id="D140" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.31391" /MaxDrop="3.85249" /score="18.9843263" /energy="-13.1" /TU="NA" /idTUdmin="U235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(321380..321399) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 321381..321388 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(321386) /Source="Nicolas_upshifts" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 321403..321422 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(321414..321419) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 321415 /Source="Nicolas_upshifts" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" CDS 321466..322440 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_388199.2" /db_xref="EnsemblGenomes-Gn:BSU03170" /db_xref="EnsemblGenomes-Tr:CAB12111" /db_xref="GOA:P94387" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12009" /db_xref="UniProtKB/Swiss-Prot:P94387" /translation="MDIKVMEYAAEIARRQSFTKAAEHLHIAQPSLSQQIKKLEAELG LTLFHRSHGSVTLTPHGRRFIEKAEDIIRSRDDLLREMQERSQGIGHKLSIGIPAVTG RYLFPPLLKQFLARYPHVEVQLVEKDPVSLEKMTAKGEVDLSVLSLPIEDERLSITPL LTEPVVLAVPKEKQRWMPPELVALIEKALEEDEGRQPCVPIDMVRNVPFILLKEGFGF RRTVLDLCAESGFKPNAAFKTSHIETAQSLVANGLGVTMAPNMVRRDKDPGVIYLSIQ SAPSRTLVFVFLKNRYVSLTAQAFMELSRESLKQTFDEGCLGNKDENI*" /label="ycgK CDS" gene 321466..322440 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /label="ycgK gene" S_feature 322441..322511 /Source="Nicolas_S_feature" /locus_tag="new_342467_342537" /HighExp="Diami, dia5, dia15, S1, dia0, C90, LBGexp, Heat, Lbexp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S113" CDS 322512..323468 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /EC_number="3.1.1.41" /EC_number="3.1.1.72" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12842474, 19837798, 21382014" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12842474, 19837798, 21382014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acetyl xylan esterase-cephalosporin C deacetylase" /protein_id="NP_388200.1" /db_xref="EnsemblGenomes-Gn:BSU03180" /db_xref="EnsemblGenomes-Tr:CAB12112" /db_xref="GOA:P94388" /db_xref="InterPro:IPR008391" /db_xref="InterPro:IPR029058" /db_xref="PDB:1L7A" /db_xref="PDB:1ODS" /db_xref="PDB:1ODT" /db_xref="SubtiList:BG11919" /db_xref="UniProtKB/Swiss-Prot:P94388" /translation="MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDL QPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEM VNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRA LEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVAL EQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPST VFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG*" /label="cah CDS" gene 322512..323468 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /label="cah gene" promotor_-35 322927..322933 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 322948..322959 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 322955 /Source="Nicolas_upshifts" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" S_feature 323469..323547 /Source="Nicolas_S_feature" /locus_tag="new_343495_343573" /HighExp="dia5, dia15, Diami, dia0, B36, S1, MG 10, BT, B60, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S114" promotor_-35 323522..323527 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 323544..323562 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 323549 /Source="Nicolas_upshifts" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" CDS 323552..324334 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388201.1" /db_xref="EnsemblGenomes-Gn:BSU03190" /db_xref="EnsemblGenomes-Tr:CAB12113" /db_xref="InterPro:IPR018775" /db_xref="SubtiList:BG12010" /db_xref="UniProtKB/Swiss-Prot:P94389" /translation="MKQRIIDELKRIEQSYGVKIVYAVESGSRAWGFPSQDSDYDVRF IYVPKKEWYFSIEQERDVIEEPIHDLLDISGWELRKTLRLFKKSNPPLLEWLSSDIVY YEAFTTAEQLRKLRTEAFKPEASVYHYINMARRNVKDYLQGQEVKIKKYFYVLRPILA CQWIEKHGTIPPMDFTVLMNELVAEPELKAEMETLLERKRRGEELDLEARIDVIHQFI ETEIERIMEAAKELKAEKKDMTSELNRLLLNTVEEVWKDGGS*" /label="ycgL CDS" gene 323552..324334 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /label="ycgL gene" downshifts 324299 /Source="Nicolas_upshifts" /id="D141" /incds=0 /nref=11 /ntot=63 /MaxReadThrough="3.94077" /MaxDrop="4.37398" /score="0.421649027" /energy="-5.9" /TU="U238" /idTUdmin="U236" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 324344..324471 /Source="Nicolas_S_feature" /locus_tag="new_344370_344497" /HighExp="S5, S6, S8, S4, S7, B36, B60, BT, S3, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S115" promotor_-35 324448..324452 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 324467..324486 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 324473 /Source="Nicolas_upshifts" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 324525..325436 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /EC_number="1.5.5.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17536821, 2118500, 21840319, 22139509, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17536821, 2118500, 21840319, 22139509, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline oxidase" /protein_id="NP_388202.1" /db_xref="EnsemblGenomes-Gn:BSU03200" /db_xref="EnsemblGenomes-Tr:CAB12114" /db_xref="GOA:P94390" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG12011" /db_xref="UniProtKB/Swiss-Prot:P94390" /translation="MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPT IRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGL DIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQA YLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYT AIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGE DWYGYFMRRLAERPSNIAFAFKGMTKK*" /label="putB CDS" gene 324525..325436 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /label="putB gene" CDS 325453..327000 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 17183215, 21840319, 22139509, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 17183215, 21840319, 22139509, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-pyrroline-5-carboxylate dehydrogenase" /protein_id="NP_388203.2" /db_xref="EnsemblGenomes-Gn:BSU03210" /db_xref="EnsemblGenomes-Tr:CAB12115" /db_xref="GOA:P94391" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12012" /db_xref="UniProtKB/Swiss-Prot:P94391" /translation="MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGE RVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLF RAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR EGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFV EVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPG QQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYD QVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDD SKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVIT NNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQA KTISEMF*" /label="putC CDS" gene 325453..327000 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /label="putC gene" promotor_-35 326424..326430 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326444..326463 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326452 /Source="Nicolas_upshifts" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 326535..326541 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326554..326573 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326563 /Source="Nicolas_upshifts" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" misc_feature 326999..327003 /Source="Nicolas_upshift_promotors" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 327001..327123 /Source="Nicolas_S_feature" /locus_tag="new_347027_347149" /HighExp="S1, T2.0H, T2.30H, Lbstat, aero, HiOs, BC, Sw, LPh, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52312199999999998" /TUshortSig="Sig-, SigA, SigA, SigA, SigEF" /TUshortPSig="0.249, 1, 0.994, 0.922, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S116" upshifts 327003 /Source="Nicolas_upshifts" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 327124..328545 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline permease" /protein_id="NP_388204.2" /db_xref="EnsemblGenomes-Gn:BSU03220" /db_xref="EnsemblGenomes-Tr:CAB12116" /db_xref="GOA:P94392" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12013" /db_xref="UniProtKB/Swiss-Prot:P94392" /translation="MLLIGYFAYKRTSNLTDYMLGGRSLGPAVTALSAGAADMSGWLL MGLPGAMFSTGLSGAWIVIGLCLGAWANWLYVAPRLRTYTEKAGNSITIPGFLENRFG DQTKLLRLFSGIVILVFFTFYVSSGMVSGGVLFNSILGMDYHTGLWIVTGVVVAYTLF GGFLAVSWTDFVQGIIMFAALILVPIVTFFHTGGAGDTVAEIRSVDPDMFNIFKGTSV LGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSAVGAVLTGLGGI AYYHQRGMTLKDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTSSSLVE DLYKSMFRRSASDKELVFLGRLAVLAVSIVALVLAWEKNNTILGLVSYAWAGFGASFG PVVLLSLFWKRMTKWGALAGMIVGAATVIIWANAGLSDFLYEMIPGFAASLLSVFFVS ILTQAPSQAVTDQFNDYQDTMSQ*" /label="putP CDS" gene 327124..328545 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /label="putP gene" S_feature complement(327644..329499) /Source="Nicolas_S_feature" /locus_tag="new_347670_349525_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, C30, T4.0H, Lbstat" /AntisenseName="ycgP" /AntisenseCor="0.143781082577395" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.679" /TUlongSig="NA" /TUlongPSig="NA" /label="S117" downshifts 328525 /Source="Nicolas_upshifts" /id="D142" /incds=0 /nref=21 /ntot=160 /MaxReadThrough="5.09597" /MaxDrop="4.17771" /score="5.89792272" /energy="-15.9" /TU="U239,U240,U242" /idTUdmin="U238" /TUdmin=4 /isTUend="TRUE" /label="downshifts" S_feature 328570..328666 /Source="Nicolas_S_feature" /locus_tag="new_348596_348692" /HighExp="S1, LPh, T2.0H, HPh, aero, Lbstat, LoTm, T2.30H, Cold, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.249, 0.994, 0.922" /TUlongSig="NA" /TUlongPSig="NA" /label="S118" promotor_-35 328637..328644 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328659..328678 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328668 /Source="Nicolas_upshifts" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 328698..329933 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21840319, 21964733, 22139509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21840319, 21964733, 22139509; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of proline degradationoperon" /protein_id="NP_388205.2" /db_xref="EnsemblGenomes-Gn:BSU03230" /db_xref="EnsemblGenomes-Tr:CAB12117" /db_xref="GOA:P94393" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12014" /db_xref="UniProtKB/Swiss-Prot:P94393" /translation="MEELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSY YINHFDSANQQTIFSKKCPVQIFERFLKDGIIEKLKTEPEPFRVNKIESIGLNQRVVV SAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEKEEKAEDLI KRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLR DKVSHVLTIESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEY NHLLKLGKSYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKD LALLKAKDEESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDL SDFRTRCQLYLDLMLMKKK*" /label="putR CDS" gene 328698..329933 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /label="putR gene" promotor_-10 complement(329492..329510) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(329509) /Source="Nicolas_upshifts" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(329524..329531) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(329917) /Source="Nicolas_upshifts" /id="D143" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="0.0291099999999993" /MaxDrop="3.08474" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(329970..330827) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388206.1" /db_xref="EnsemblGenomes-Gn:BSU03240" /db_xref="EnsemblGenomes-Tr:CAB12118" /db_xref="GOA:P94394" /db_xref="InterPro:IPR015402" /db_xref="SubtiList:BG12015" /db_xref="UniProtKB/Swiss-Prot:P94394" /translation="MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAI LTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGI FFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKY SSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIH CIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKP DDPYVYRGF*" /label="ycgQ CDS" gene complement(329970..330827) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /label="ycgQ gene" downshifts complement(329983) /Source="Nicolas_upshifts" /id="D144" /incds=0 /nref=48 /ntot=167 /MaxReadThrough="1.97725" /MaxDrop="4.53007" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(330832..331716) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388207.1" /db_xref="EnsemblGenomes-Gn:BSU03250" /db_xref="EnsemblGenomes-Tr:CAB12119" /db_xref="GOA:P94395" /db_xref="InterPro:IPR005524" /db_xref="SubtiList:BG12016" /db_xref="UniProtKB/Swiss-Prot:P94395" /translation="MTAQSSFLQLNSIFISILIEAIPFILIGVILSGIIQMFVSEEMI ARIMPKNRFLAVLFGALAGVLFPACECGIIPITRRLLLKGVPLHAGVAFMLTAPIINP IVLFSTYIAFGNRWSVVFYRGGLALAVSLIIGVILSYQFKDNQLLKPDEPGHHHHHHG TLLQKLGGTLRHAIDEFFSVGKYLIIGAFIAAAMQTYVKTSTLLAIGQNDVSSSLVMM GLAFVLSLCSEVDAFIASSFSSTFSLGSLIAFLVFGAMVDIKNLLMMLAAFKKRFVFL LITYIVVIVLAGSLLVKG*" /label="ycgR CDS" gene complement(330832..331716) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /label="ycgR gene" upshifts complement(331768) /Source="Nicolas_upshifts" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(331773..331786) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(331801..331809) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(331816..332670) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /EC_number="3.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic hydrocarbon hydrolase" /protein_id="NP_388208.1" /db_xref="EnsemblGenomes-Gn:BSU03260" /db_xref="EnsemblGenomes-Tr:CAB12120" /db_xref="GOA:P94396" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12017" /db_xref="UniProtKB/Swiss-Prot:P94396" /translation="MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTA LIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSG ICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAF PRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLK DLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGS ILLGFLES*" /label="ycgS CDS" gene complement(331816..332670) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /label="ycgS gene" promotor_-10 complement(332689..332708) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-10" upshifts complement(332709) /Source="Nicolas_upshifts" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="upshifts" promotor_-35 complement(332723..332726) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-35" misc_feature 332760..332779 /Source="Nicolas_upshift_promotors" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(332760..332778) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 332767..332831 /Source="Nicolas_S_feature" /locus_tag="new_352793_352857" /HighExp="B60, Lbexp, LBGexp, dia0, B36, HiOs, GM 15, GM 10, Salt, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S119" upshifts 332768 /Source="Nicolas_upshifts" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(332777) /Source="Nicolas_upshifts" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(332794..332799) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 332832..333842 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /EC_number="1.18.1.-" /EC_number="1.8.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16672620, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 25826316; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Fur-regulated NADPH:ferredoxin oxidoreductase" /protein_id="NP_388209.1" /db_xref="EnsemblGenomes-Gn:BSU03270" /db_xref="EnsemblGenomes-Tr:CAB12121" /db_xref="GOA:O31475" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12018" /db_xref="UniProtKB/Swiss-Prot:O31475" /translation="MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG KVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIV LTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVI SGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNG DEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMR TNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV HK*" /label="ffoR CDS" gene 332832..333842 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /label="ffoR gene" S_feature 333843..336290 /Source="Nicolas_S_feature" /locus_tag="new_353869_356316" /HighExp="B60, Lbexp, GM 10, GM 25, HiOs, GM 15, dia0, GM 45, LBGexp, H2O2" /AntisenseName="nasF" /AntisenseCor="-0.30348565853404702" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S120" CDS complement(333874..335325) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /EC_number="2.1.1.107" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9765565, 10217486, 15028686" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765565, 10217486, 15028686; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrin-III C-methyltransferase" /protein_id="NP_388210.1" /db_xref="EnsemblGenomes-Gn:BSU03280" /db_xref="EnsemblGenomes-Tr:CAB12122" /db_xref="GOA:P42437" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR012409" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG11098" /db_xref="UniProtKB/Swiss-Prot:P42437" /translation="MIMKNGIVYFVGAGPGDPGLLTIKGKQALKEADVILYDRLANPK LLEFASPDCQFIYCGKLPNRHFMKQKEINALLVEKALNGLTVVRLKGGDPSVFGRVGE EADALHEHGIRYEMVPGITSGIAAPLYAGIPVTHRDFASSFAMITAHDKSLKGTPNLD WEGLARSVQTLVFYMGVKNLSYICQQLISYGKSPSVPVIVIQWGTWGRQRSVKGTLEN IQQKVQEHQITNPAIIVIGDIVNFQTHSWFESKPLIGRHLMVVTHGEDEDPLADKLRD SGADLIEWPKWRTENMPVNEEILRKIGTFEDVFFTSRRAVCEFFRALASQKIDIRQLT AKLSAASEQAKTELEKRGFLVTAIQPDSEKRLVVGSRHAVENMQKHESCSFYITHENV IDDRFTHMIQRTISESPLHMVICPNKLSVQQLINGGEQIGILPEPSASRPPIVCIGDD SAAGIYGFTAVQEQDELLAFIHNQHAEKKLLHT*" /label="nasF CDS" gene complement(333874..335325) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /label="nasF gene" downshifts complement(333878) /Source="Nicolas_upshifts" /id="D145" /incds=0 /nref=131 /ntot=230 /MaxReadThrough="1.40657" /MaxDrop="6.58881" /score="10.9556399" /energy="-11.7" /TU="NA" /idTUdmin="U250" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(335386..335706) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 15028686, 9765565, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 15028686, 9765565, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388211.1" /db_xref="EnsemblGenomes-Gn:BSU03290" /db_xref="EnsemblGenomes-Tr:CAB12123" /db_xref="GOA:P42436" /db_xref="InterPro:IPR012748" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11097" /db_xref="UniProtKB/Swiss-Prot:P42436" /translation="MVNKDVTKVCIGKIEELPEQLGKTVYIEDKELAVFKLSDGSIRA IENRCPHKGGVLAEGIVSGQYVFCPMHDWKISLEDGIVQEPDHGCVKTYETLIEGEHV YLVY*" /label="nasE CDS" gene complement(335386..335706) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /label="nasE gene" promotor_-35 335557..335562 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 335576..335580 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 335583 /Source="Nicolas_upshifts" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(335615) /Source="Nicolas_upshifts" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(335617..335636) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(335650..335657) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(335738..338155) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565, 16428414, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565, 16428414, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388212.1" /db_xref="EnsemblGenomes-Gn:BSU03300" /db_xref="EnsemblGenomes-Tr:CAB12124" /db_xref="GOA:P42435" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11096" /db_xref="UniProtKB/Swiss-Prot:P42435" /translation="MGKKQLVLVGNGMAGVRAIEEILSVAKDEFQITIFGAEPHPNYN RILLSKVLQGDTDIKDITLNDWDWYEENNIQLYTNETVIKVDTENKTVITDADRIQPY DELILATGSVPFILPIPGADKKGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEA ARGLLNLGMDVSVIHLAPFLMERQLDATAGRLLQNELEKQGMTFLLEKQTEEIVGDDR VEGLRFKDGTSIEADLVVMAVGIRPNTTLGAESGIPVNRGIIVNDYMQTEIPHIYAVG ECAEHRGIAYGLVAPLYEQAKVLAKHMCGIETKPYEGSVLSTQLKVSGVEVFSAGDFN ESEEKKAIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGNRLFSMIQKEADISETSK ISILQPLSQEAGTSITAAMSDDEIICGCNGVSKGAIIQAIQEKGCSSTDEIKACTGAS RSCGGCKPLVEEILQHTLGSDFDASAQKEAICGCTTLSRDEVVEEIKAKGLSHTREVM NVLGWKTPEGCSKCRPALNYYLGMINPTKYEDDRTSRFVNERMHANIQKDGTYSVVPR MYGGVTNSTDLRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWEDLDMPSGYA YGKTLRTVKTCVGEQFCRFGTQDSMALGIALEKKFEGLNTPHKVKMAVSACPRNCAES GIKDLGVVGIDGGWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANY LERTSAWLERVGLSHVQSVLNDPEKRQELNGRMNETLSVHKDPWKDFLEDKQTSKELF ENVVTTS*" /label="nasD CDS" gene complement(335738..338155) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /label="nasD gene" promotor_-10 complement(338180..338199) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(338194) /Source="Nicolas_upshifts" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(338211..338217) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(338277..340409) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /EC_number="1.7.99.4" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (catalytic subunit)" /protein_id="NP_388213.2" /db_xref="EnsemblGenomes-Gn:BSU03310" /db_xref="EnsemblGenomes-Tr:CAB12125" /db_xref="GOA:P42434" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="SubtiList:BG11095" /db_xref="UniProtKB/Swiss-Prot:P42434" /translation="MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVT RKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHI KDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAAT AANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDP RETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDS LDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLIT GKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDEL PRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISE TAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKG RYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTE SFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARH FESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQN VNDLIGEALDPACKMPGFKVCAVRIIPI*" /label="nasC CDS" gene complement(338277..340409) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /label="nasC gene" CDS complement(340416..342731) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /EC_number="1.7.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (electron transfer subunit NasB)" /protein_id="NP_388214.2" /db_xref="EnsemblGenomes-Gn:BSU03320" /db_xref="EnsemblGenomes-Tr:CAB12126" /db_xref="GOA:P42433" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11094" /db_xref="UniProtKB/Swiss-Prot:P42433" /translation="MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYN RILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSY DKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEA AVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATK ADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVG ECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQ EDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKK QIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCG GCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLD WKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANI IEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQN RSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVR GTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFE EDLRAQLLESLQTDLSLIQNPTVETGAYKKG*" /label="nasB CDS" gene complement(340416..342731) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /label="nasB gene" promotor_no_box complement(342750..342850) /Source="Nicolas_upshift_promotors" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(342790) /Source="Nicolas_upshifts" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 342833..342840 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 342854..342873 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 342866 /Source="Nicolas_upshifts" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="upshifts" CDS 342911..344116 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7868621, 12823818, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative nitrate transporter" /protein_id="NP_388215.2" /db_xref="EnsemblGenomes-Gn:BSU03330" /db_xref="EnsemblGenomes-Tr:CAB12127" /db_xref="GOA:P42432" /db_xref="InterPro:IPR004737" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11093" /db_xref="UniProtKB/Swiss-Prot:P42432" /translation="MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFG LSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSL TELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLA EQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLY SVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTK VLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMV TGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSW SAESSPADV*" /label="nasA CDS" gene 342911..344116 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /label="nasA gene" downshifts 344101 /Source="Nicolas_upshifts" /id="D146" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.02479" /MaxDrop="3.6823" /score="39.2612286" /energy="-11.9" /TU="NA" /idTUdmin="U253" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 344160..344166 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-35" promotor_-10 344181..344200 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-10" upshifts 344189 /Source="Nicolas_upshifts" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="upshifts" CDS 344233..345147 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12426338, 17032654, 19767425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12426338, 17032654, 19767425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_388216.2" /db_xref="EnsemblGenomes-Gn:BSU03340" /db_xref="EnsemblGenomes-Tr:CAB12128" /db_xref="GOA:P94398" /db_xref="InterPro:IPR003801" /db_xref="InterPro:IPR022838" /db_xref="SubtiList:BG12019" /db_xref="UniProtKB/Swiss-Prot:P94398" /translation="MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDY FFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVY HQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMS VTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVK ADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAF EIECRNEESIHLHDAYAKLCFSKEVDKI*" /label="folEB CDS" gene 344233..345147 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /label="folEB gene" CDS 345144..345728 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12426338, 20013255; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative Zn(2+)-dependent division lipoprotein (schizosome)" /protein_id="NP_388217.2" /db_xref="EnsemblGenomes-Gn:BSU03350" /db_xref="EnsemblGenomes-Tr:CAB12129" /db_xref="GOA:C0SP99" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG12020" /db_xref="UniProtKB/Swiss-Prot:C0SP99" /translation="MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRK TAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKD DATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAE KLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS*" /label="yciB CDS" gene 345144..345728 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /label="yciB gene" promotor_-35 345739..345746 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 345760..345779 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 345770 /Source="Nicolas_upshifts" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="upshifts" CDS 345824..346009 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097674.1" /db_xref="EnsemblGenomes-Gn:BSU03359" /db_xref="EnsemblGenomes-Tr:CAX52544" /db_xref="UniProtKB/Swiss-Prot:C0H3U7" /translation="MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSA KSCSTPLYIRRSIQFKS*" /label="yczL CDS" gene 345824..346009 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /label="yczL gene" CDS 346037..347230 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249; Product type t: transporter" /codon_start=1 /transl_table=11 /product="zinc metallochaperone with NTPase activity" /protein_id="NP_388218.1" /db_xref="EnsemblGenomes-Gn:BSU03360" /db_xref="EnsemblGenomes-Tr:CAB12130" /db_xref="GOA:P94400" /db_xref="InterPro:IPR003495" /db_xref="InterPro:IPR011629" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036627" /db_xref="SubtiList:BG12021" /db_xref="UniProtKB/Swiss-Prot:P94400" /translation="MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVN IDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGI SEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGE KDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVK PQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFY RWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQ QEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFK WKLNQ*" /label="zinU CDS" gene 346037..347230 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /label="zinU gene" downshifts 347222 /Source="Nicolas_upshifts" /id="D147" /incds=0 /nref=26 /ntot=45 /MaxReadThrough="5.12378" /MaxDrop="5.8275" /score="15.6427627" /energy="-9.2" /TU="U255" /idTUdmin="U255" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" S_feature 347267..348936 /Source="Nicolas_S_feature" /locus_tag="new_367293_368962" /HighExp="Etha, B60, Cold, Heat, B36, C30, BMM, S6, C90, S2" /AntisenseName="yckB" /AntisenseCor="-0.170121935628575" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S121" CDS complement(347279..347959) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aminoacid ABC transporter (permease subunit)" /protein_id="NP_388219.1" /db_xref="EnsemblGenomes-Gn:BSU03370" /db_xref="EnsemblGenomes-Tr:CAB12131" /db_xref="GOA:P42399" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11177" /db_xref="UniProtKB/Swiss-Prot:P42399" /translation="MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVI GLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIG FSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANV LLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNIL EKKYAHYV*" /label="yckA CDS" gene complement(347279..347959) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /label="yckA gene" downshifts complement(347285) /Source="Nicolas_upshifts" /id="D148" /incds=0 /nref=101 /ntot=231 /MaxReadThrough="0.41655" /MaxDrop="6.18136" /score="40.1548023" /energy="-12.6" /TU="NA" /idTUdmin="U256" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(347969..348832) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23038252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="amino acid ABC transporter (binding lipoprotein subunit)" /protein_id="NP_388220.1" /db_xref="EnsemblGenomes-Gn:BSU03380" /db_xref="EnsemblGenomes-Tr:CAB12132" /db_xref="GOA:P42400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="PDB:2IEE" /db_xref="SubtiList:BG11178" /db_xref="UniProtKB/Swiss-Prot:P42400" /translation="MKSFMHSKAVIFSFTMAFFLILAACSGKNEADSKDTGWEQIKDK GKIVVATSGTLYPTSYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGIDGMLTA VNSGQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDLKGKKAA GAATTVYMEVARKYGAKEVIYDNATNEQYLKDVANGRTDVILNDYYLQTLALAAFPDL NITIHPDIKYMPNKQALVMKKSNAALQKKMNEALKEMSKDGSLTKLSKQFFNKADVSK KIDADVQDVDL*" /label="yckB CDS" gene complement(347969..348832) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /label="yckB gene" promotor_-10 complement(348854..348873) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(348866) /Source="Nicolas_upshifts" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(348868..351702) /Source="Nicolas_S_feature" /locus_tag="new_368894_371728_c" /HighExp="GM 150, T-4.40H, G/S, Pyr, S2, C30, T-5.40H, C90, T-3.40H, T0.30H" /AntisenseName="bglC" /AntisenseCor="-0.37749573319969598" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, Sig-" /TUshortPSig="0.248, 0.994, 0.0879" /TUlongSig="SigD" /TUlongPSig=1 /label="S122" promotor_-35 complement(348888..348895) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 348905..348911 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 348926..348944 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 348938..349160 /Source="Nicolas_S_feature" /locus_tag="new_368964_369186" /HighExp="Etha, Salt, B60, Sw, B36, Gly, Heat, S6, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99896700000000005" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S123" upshifts 348938 /Source="Nicolas_upshifts" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 348994..349191 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513942.1" /translation="MSKDECQTYQGNACESEGCSRPVTHLCQYRKKWSRGMKPIFRIN LSLADAPKAYDIFDEKENGNI*" /label="hypothetical protein CDS" gene 348994..349191 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /label="gene" promotor_-35 349129..349134 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 349150..349168 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 349162 /Source="Nicolas_upshifts" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 349210..349665 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral membrane protein of unknown function" /protein_id="NP_388221.1" /db_xref="EnsemblGenomes-Gn:BSU03390" /db_xref="EnsemblGenomes-Tr:CAB12133" /db_xref="GOA:P42401" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11179" /db_xref="UniProtKB/Swiss-Prot:P42401" /translation="MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMF ISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITF GLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE*" /label="yckC CDS" gene 349210..349665 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /label="yckC gene" downshifts 349640 /Source="Nicolas_upshifts" /id="D149" /incds=0 /nref=40 /ntot=193 /MaxReadThrough="1.14817" /MaxDrop="5.48303" /score="23.1539807" /energy="-9.8" /TU="NA" /idTUdmin="U257" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 349688..349694 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 349701 /Source="Nicolas_upshifts" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 349708..349719 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 349747..350079 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388222.1" /db_xref="EnsemblGenomes-Gn:BSU03400" /db_xref="EnsemblGenomes-Tr:CAB12134" /db_xref="InterPro:IPR024485" /db_xref="SubtiList:BG11180" /db_xref="UniProtKB/Swiss-Prot:P42402" /translation="MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQK KEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPH PHKFEKRH*" /label="yckD CDS" gene 349747..350079 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /label="yckD gene" downshifts 350060 /Source="Nicolas_upshifts" /id="D150" /incds=0 /nref=20 /ntot=44 /MaxReadThrough="2.48743" /MaxDrop="4.3022" /score="-1.40416926" /energy="-11.8" /TU="NA" /idTUdmin="U259" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 350165..350172 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350188..350207 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 350192 /Source="Nicolas_upshifts" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="upshifts" CDS 350233..351666 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18069788" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18069788; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_388223.1" /db_xref="EnsemblGenomes-Gn:BSU03410" /db_xref="EnsemblGenomes-Tr:CAB12135" /db_xref="GOA:P42403" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11181" /db_xref="UniProtKB/Swiss-Prot:P42403" /translation="MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKI PGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLA FYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGD RVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPE GKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGW APTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIP GVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTV QDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEE STSDLKRLKKKSFYWYQDVIKTNGESL*" /label="bglC CDS" gene 350233..351666 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /label="bglC gene" downshifts 351644 /Source="Nicolas_upshifts" /id="D151" /incds=0 /nref=12 /ntot=61 /MaxReadThrough="1.51167" /MaxDrop="4.6748" /score="18.0928088" /energy="-15.9" /TU="NA" /idTUdmin="U260" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(351703..352101) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11359569, 11814663, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11359569, 11814663, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the DNA degrading activity of NucA (competence)" /protein_id="NP_388224.1" /db_xref="EnsemblGenomes-Gn:BSU03420" /db_xref="EnsemblGenomes-Tr:CAB12136" /db_xref="GOA:P12669" /db_xref="InterPro:IPR020354" /db_xref="PDB:4MQD" /db_xref="SubtiList:BG10839" /db_xref="UniProtKB/Swiss-Prot:P12669" /translation="MIKSWKPQELSISYHQFTVFQKDSTPPVMDWTDEAIEKGYAAAD GAISFEAQRNTKAFILFRLNSSETVNSYEKKVTVPFHVTENGIHIESIMSKRLSFDLP KGDYQLTCWTVPAEMSDLHADTYIIDAVSV*" /label="nin CDS" gene complement(351703..352101) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /label="nin gene" promotor_no_box complement(352098..352198) /Source="Nicolas_upshift_promotors" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="promotor_no_box" CDS complement(352128..352577) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2841296, 7746143, 11359569, 11814663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2841296, 7746143, 11359569, 11814663; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease" /protein_id="NP_388225.3" /db_xref="EnsemblGenomes-Gn:BSU03430" /db_xref="EnsemblGenomes-Tr:CAB12137" /db_xref="GOA:P12667" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG10838" /db_xref="UniProtKB/Swiss-Prot:P12667" /translation="MNITTDIIKTILLVIVIIAAAAVGLIKGDFFSADQKTSQTKEYD ETMAFPSDRYPETAKHIKDAINEGHSEVCTIDRDGAEERREQSLKDVPSKKGYDRDEW PMAMCKEGGEGASVEYISPADNRGAGSWVGHRLTDYPDGTKVLFTIQ*" /label="nucA CDS" gene complement(352128..352577) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /label="nucA gene" upshifts complement(352138) /Source="Nicolas_upshifts" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(352592..352611) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(352600) /Source="Nicolas_upshifts" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(352602..352744) /Source="Nicolas_S_feature" /locus_tag="new_372628_372770_c" /HighExp="C30, Diami, M40t45, Cold, Lbstat, T0.30H, M0t90, dia15, C90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD" /TUshortPSig="0.0879, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S124" promotor_-35 complement(352625..352632) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(352745..354466) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7704255, 7921238, 15187186, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704255, 7921238, 15187186, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (plant colonization)" /protein_id="NP_388226.2" /db_xref="EnsemblGenomes-Gn:BSU03440" /db_xref="EnsemblGenomes-Tr:CAB12138" /db_xref="GOA:P39209" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="SubtiList:BG10790" /db_xref="UniProtKB/Swiss-Prot:P39209" /translation="MLIKRFKMKLGTKILCLVFVVILLFSASVGTVMLKEITESMKQM ATEKAKGDLALSSTYIDDVMSGDWQVKNNKLYKGQTQINGNEDIVDLLGEKTGDTITI FQGDTRVATNVMKNGERAVGTQASSEVIAAVLKKGKRFYGQADVAGSSYQTAYMPLKD QNGNIIGMLYTGANQSILASLTQSLFTQFAIVLVIVIMVSVILVLVFTRKINKRLNAL KSAFESAGNGDMTIEVSDKTGDELSELSVYYNKMRMKLNDTIQTVQQSALQLASASQQ LSAGAEETNQASEKITEAVQQIANGAQDQITRIENSESSLKQASADIRDISANTAAIA DKGQLAQSKADIGQKEIANVQAQMDAIHQSIQKSGEIIHQLDGRSKQIEQILSVITQI ADQTNLLALNAAIEAARAGEQGKGFAVVADEVRKLAEESQQSAGQISKLIIEIQKDMN RSARSVEHVKTEAAEGVTMIQRTRDAFKEIAAATGEISAEISDLSASVTNISASAHQI NDSFAANTADIKESTKNTRQAAALTEEQFAAMEEITAASETLSQLAEELTGIISQFKM INQAENG*" /label="tlpC CDS" gene complement(352745..354466) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /label="tlpC gene" promotor_-35 352757..352764 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 352775..355918 /Source="Nicolas_S_feature" /locus_tag="new_372801_375944" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, T4.0H, T0.0H, T-0.40H" /AntisenseName="tlpC" /AntisenseCor="-0.40398083053643302" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S125" upshifts 352775 /Source="Nicolas_upshifts" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 352779..352798 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box complement(352780..352880) /Source="Nicolas_upshift_promotors" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="promotor_no_box" upshifts complement(352820) /Source="Nicolas_upshifts" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="upshifts" promotor_-10 complement(354490..354508) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-10" upshifts complement(354505) /Source="Nicolas_upshifts" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="upshifts" promotor_-35 complement(354522..354529) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-35" CDS complement(354577..355134) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /EC_number="5.3.1.27" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-3-hexuloisomerase (PHI)" /protein_id="NP_388227.1" /db_xref="EnsemblGenomes-Gn:BSU03450" /db_xref="EnsemblGenomes-Tr:CAB12139" /db_xref="GOA:P42404" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR017552" /db_xref="PDB:1M3S" /db_xref="PDB:1VIV" /db_xref="SubtiList:BG11182" /db_xref="UniProtKB/Swiss-Prot:P42404" /translation="MKTTEYVAEILNELHNSAAYISNEEADQLADHILSSHQIFTAGA GRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGDLVIIGSGSGETKSLIHTAAKAK SLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSNGSYKTIQPMGSLFEQTLLLFYD AVILKLMEKKGLDSETMFTHHANLE*" /label="hxlB CDS" gene complement(354577..355134) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /label="hxlB gene" downshifts complement(354580) /Source="Nicolas_upshifts" /id="D152" /incds=0 /nref=51 /ntot=130 /MaxReadThrough="1.98332" /MaxDrop="6.56052" /score="42.3682356" /energy="-15.4" /TU="NA" /idTUdmin="U266" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(355140..355772) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /EC_number="4.1.2.43" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hexulose-6-phosphate synthase (HPS)" /protein_id="NP_388228.1" /db_xref="EnsemblGenomes-Gn:BSU03460" /db_xref="EnsemblGenomes-Tr:CAB12140" /db_xref="GOA:P42405" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017553" /db_xref="SubtiList:BG11183" /db_xref="UniProtKB/Swiss-Prot:P42405" /translation="MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAV KEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQ KKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG*" /label="hxlA CDS" gene complement(355140..355772) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /label="hxlA gene" promotor_-10 complement(355798..355817) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(355813) /Source="Nicolas_upshifts" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(355832..355835) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 355896..355899 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 355914..355933 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 355920 /Source="Nicolas_upshifts" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="upshifts" CDS 356006..356368 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15978081, 26973631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15978081, 26973631; Product type r: regulator" /codon_start=1 /transl_table=11 /product="positive regulator of hxlAB expression (formaldehyde sensing)" /protein_id="NP_388229.2" /db_xref="EnsemblGenomes-Gn:BSU03470" /db_xref="EnsemblGenomes-Tr:CAB12141" /db_xref="GOA:P42406" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11184" /db_xref="UniProtKB/Swiss-Prot:P42406" /translation="MSRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELK TLIPDITQKILVNQLRELEQDMIVHREVYPVVPPKVEYSLTPHGESLMPILEAMYEWG KGYMELIDIDKNVMKESL*" /label="hxlR CDS" gene 356006..356368 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /label="hxlR gene" downshifts 356352 /Source="Nicolas_upshifts" /id="D153" /incds=0 /nref=14 /ntot=154 /MaxReadThrough="3.13609" /MaxDrop="3.66949" /score="20.4643411" /energy="-9.6" /TU="U267" /idTUdmin="U263" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 356615..356618 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 356633..356652 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 356641..356941 /Source="Nicolas_S_feature" /locus_tag="new_376667_376967" /HighExp="HiOs, T-1.10H, T5.0H, T4.0H, T-1.40H, S2, M9-stat, T3.30H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.20585600000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S126" upshifts 356641 /Source="Nicolas_upshifts" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="upshifts" CDS 356942..367705 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388230.2" /db_xref="EnsemblGenomes-Gn:BSU03480" /db_xref="EnsemblGenomes-Tr:CAB12142" /db_xref="GOA:P27206" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10168" /db_xref="UniProtKB/Swiss-Prot:P27206" /translation="MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDY VLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQ WSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYL ELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASA GGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTF MGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLI NDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTG KLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARA GGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGV GPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTES KVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQV HHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGA ALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFK EAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQ PEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEY LGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSE FAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAP RNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLF EHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPA AAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGR SDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELAR IYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPV QSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPS AGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVE DLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDE GIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQF NPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGA GEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQR KLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIV THANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLD MARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQT VGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAG IAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGR IDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQE MREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTE QKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTV EGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLT GELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERI VSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGE TLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFE GDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRS QADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQV QRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTF VLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKA LPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDD RVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISV PDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVE HHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLD IVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNY GPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLA RGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIEL SEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIP AFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEV GVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDAL RMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGG LLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSF AEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTA EETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTIS RTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDV AFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLT MSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDK LMEIF*" /label="srfAA CDS" gene 356942..367705 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /label="srfAA gene" CDS 367718..378469 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388231.2" /db_xref="EnsemblGenomes-Gn:BSU03490" /db_xref="EnsemblGenomes-Tr:CAB12143" /db_xref="GOA:Q04747" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10169" /db_xref="UniProtKB/Swiss-Prot:Q04747" /translation="MSKKSIQKVYALTPMQEGMLYHAMLDPHSSSYFTQLELGIHGAF DLEIFEKSVNELIRSYDILRTVFVHQQLQKPRQVVLAERKTKVHYEDISHADENRQKE HIERYKQDVQRQGFNLAKDILFKVAVFRLAADQLYLVWSNHHIMMDGWSMGVLMKSLF QNYEALRAGRTPANGQGKPYSDYIKWLGKQDNEEAESYWSERLAGFEQPSVLPGRLPV KKDEYVNKEYSFTWDETLVARIQQTANLHQVTGPNLFQAVWGIVLSKYNFTDDVIFGT VVSGRPSEINGIETMAGLFINTIPVRVKVERDAAFADIFTAVQQHAVEAERYDYVPLY EIQKRSALDGNLLNHLVAFENYPLDQELENGSMEDRLGFSIKVESAFEQTSFDFNLIV YPGKTWTVKIKYNGAAFDSAFIERTAEHLTRMMEAAVDQPAAFVREYGLVGDEEQRQI VEVFNSTKAELPEGMAVHQVFEEQAKRTPASTAVVYEGTKLTYRELNAAANRLARKLV EHGLQKGETAAIMNDRSVETVVGMLAVLKAGAAYVPLDPALPGDRLRFMAEDSSVRMV LIGNSYTGQAHQLQVPVLTLDIGFEESEAADNLNLPSAPSDLAYIMYTSGSTGKPKGV MIEHKSILRLVKNAGYVPVTEEDRMAQTGAVSFDAGTFEVFGALLNGAALYPVKKETL LDAKQFAAFLREQSITTMWLTSPLFNQLAAKDAGMFGTLRHLIIGGDALVPHIVSKVK QASPSLSLWNGYGPTENTTFSTSFLIDREYGGSIPIGKPIGNSTAYIMDEQQCLQPIG APGELCVGGIGVARGYVNLPELTEKQFLEDPFRPGERIYRTGDLARWLPDGNIEFLGR IDNQVKVRGFRIELGEIETKLNMAEHVTEAAVIIRKNKADENEICAYFTADREVAVSE LRKTLSQSLPDYMVPAHLIQMDSLPLTPNGKINKKELPAPQSEAVQPEYAAPKTESEK KLAEIWEGILGVKAGVTDNFFMIGGHSLKAMMMTAKIQEHFHKEVPIKVLFEKPTIQE LALYLEENESKEEQTFEPIRQASYQQHYPVSPAQRRMYILNQLGQANTSYNVPAVLLL EGEVDKDRLENAIQQLINRHEILRTSFDMIDGEVVQTVHKNISFQLEAAKGREEDAEE IIKAFVQPFELNRAPLVRSKLVQLEEKRHLLLIDMHHIITDGSSTGILIGDLAKIYQG ADLELPQIHYKDYAVWHKEQTNYQKDEEYWLDVFKGELPILDLPADFERPAERSFAGE RVMFGLDKQITAQIKSLMAETDTTMYMFLLAAFNVLLSKYASQDDIIVGSPTAGRTHP DLQGVPGMFVNTVALRTAPAGDKTFAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTR DTSRSPLFSVMFNMQNMEIPSLRLGDLKISSYSMLHHVAKFDLSLEAVEREEDIGLSF DYATALFKDETIRRWSRHFVNIIKAAAANPNVRLSDVDLLSSAETAALLEERHMTQIT EATFAALFEKQAQQTPDHSAVKAGGNLLTYRELDEQANQLAHHLRAQGAGNEDIVAIV MDRSAEVMVSILGVMKAGAAFLPIDPDTPEERIRYSLEDSGAKFAVVNERNMTAIGQY EGIIVSLDDGKWRNESKERPSSISGSRNLAYVIYTSGTTGKPKGVQIEHRNLTNYVSW FSEEAGLTENDKTVLLSSYAFDLGYTSMFPVLLGGGELHIVQKETYTAPDEIAHYIKE HGITYIKLTPSLFHTIVNTASFAKDANFESLRLIVLGGEKIIPTDVIAFRKMYGHTEF INHYGPTEATIGAIAGRVDLYEPDAFAKRPTIGRPIANAGALVLNEALKLVPPGASGQ LYITGQGLARGYLNRPQLTAERFVENPYSPGSLMYKTGDVVRRLSDGTLAFIGRADDQ VKIRGYRIEPKEIETVMLSLSGIQEAVVLAVSEGGLQELCAYYTSDQDIEKAELRYQL SLTLPSHMIPAFFVQVDAIPLTANGKTDRNALPKPNAAQSGGKALAAPETALEESLCR IWQKTLGIEAIGIDDNFFDLGGHSLKGMMLIANIQAELEKSVPLKALFEQPTVRQLAA YMEASAVSGGHQVLKPADKQDMYPLSSAQKRMYVLNQLDRQTISYNMPSVLLMEGELD ISRLRDSLNQLVNRHESLRTSFMEANGEPVQRIIEKAEVDLHVFEAKEDEADQKIKEF IRPFDLNDAPLIRAALLRIEAKKHLLLLDMHHIIADGVSRGIFVKELALLYKGEQLPE PTLHYKDFAVWQNEAEQKERMKEHEAYWMSVLSGELPELDLPLDYARPPVQSFKGDTI RFRTGSETAKAVEKLLAETGTTLHMVLHAVFHVFLSKISGQRDIVIGSVTAGRTNADV QDMPGMFVNTLALRMEAKEQQTFAELLELAKQTNLSALEHQEYPFEDLVNQLDLPRDM SRNPLFNVMVTTENPDKEQLTLQNLSISPYEAHQGTSKFDLTLGGFTDENGIGLQLEY ATDLFAKETAEKWSEYVLRLLKAVADNPNQPLSSLLLVTETEKQALLEAWKGKALPVP TDKTVHQLFEETVQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGV LTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSY TGDVILLDGSRTILSLPLDENDEGNPETAVTAENLAYMIYTSGTTGQPKGVMVEHHAL VNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDIVRL NDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTE NTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYL NREDETAKRFVADPFVPGERMYRTGDLVKWVNGGIEYIGRIDQQVKVRGYRIELSEIE VQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPETADIEALKSTLKETLPDYMIPAFWV TLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTD NFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVE GEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVY REENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKLQSSLDLRNGPLLK AEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDW AEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTAEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVG WFTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEIS FNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKE FERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENL K*" /label="srfAB CDS" gene 367718..378469 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /label="srfAB gene" CDS 370854..370994 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" /label="comS CDS" gene 370854..370994 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /label="comS gene" CDS 378506..382333 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388233.2" /db_xref="EnsemblGenomes-Gn:BSU03510" /db_xref="EnsemblGenomes-Tr:CAB12145" /db_xref="GOA:Q08787" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="PDB:1JMK" /db_xref="PDB:2VSQ" /db_xref="SubtiList:BG10170" /db_xref="UniProtKB/Swiss-Prot:Q08787" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVK GSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSE QTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQ DLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQ RKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLA FGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYV PLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMA SPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFL LTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQK HGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLL THQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKG NITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHT LLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKA LRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQ PFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEY AGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLS AEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNE MEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAP TIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCA FDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMV DSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLIS TGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEI LLEFLNTQTVTVS*" /label="srfAC CDS" gene 378506..382333 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /label="srfAC gene" CDS 382362..383090 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388234.1" /db_xref="EnsemblGenomes-Gn:BSU03520" /db_xref="EnsemblGenomes-Tr:CAB12146" /db_xref="GOA:Q08788" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR012223" /db_xref="InterPro:IPR029058" /db_xref="PDB:2K2Q" /db_xref="PDB:2RON" /db_xref="SubtiList:BG10171" /db_xref="UniProtKB/Swiss-Prot:Q08788" /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLA AEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLERE GIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSF RSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMF LLSQTEEVAERIFAILNQHPIIQP*" /label="srfAD CDS" gene 382362..383090 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /label="srfAD gene" downshifts 383072 /Source="Nicolas_upshifts" /id="D154" /incds=0 /nref=196 /ntot=261 /MaxReadThrough="4.65721" /MaxDrop="6.48992" /score="24.9581454" /energy="-11.1" /TU="U268" /idTUdmin="U268" /TUdmin="-1339" /isTUend="FALSE" /label="downshifts" promotor_-35 383128..383135 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 383138 /Source="Nicolas_upshifts" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 383147..383166 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 383191..384417 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15849754, 16850406, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter" /protein_id="NP_388235.2" /db_xref="EnsemblGenomes-Gn:BSU03530" /db_xref="EnsemblGenomes-Tr:CAB12147" /db_xref="GOA:Q08791" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10172" /db_xref="UniProtKB/Swiss-Prot:Q08791" /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADR SLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFS AIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPY HAGWQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIH ILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLG SRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISE SYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIEL VPFLDKQKAKETHHSI*" /label="srfT CDS" gene 383191..384417 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /label="srfT gene" downshifts 384411 /Source="Nicolas_upshifts" /id="D155" /incds=0 /nref=15 /ntot=198 /MaxReadThrough="2.67601" /MaxDrop="4.06773" /score="7.33278866" /energy="-13.2" /TU="NA" /idTUdmin="U268" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(384432..384989) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 21965396" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388236.1" /db_xref="EnsemblGenomes-Gn:BSU03540" /db_xref="EnsemblGenomes-Tr:CAB12148" /db_xref="GOA:Q08793" /db_xref="InterPro:IPR025588" /db_xref="SubtiList:BG10173" /db_xref="UniProtKB/Swiss-Prot:Q08793" /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFA AVNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKS KRTYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEE EMNRFKEIILKNTETKKLKFKKDQH*" /label="ycxB CDS" gene complement(384432..384989) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /label="ycxB gene" promotor_no_box complement(384447..384547) /Source="Nicolas_upshift_promotors" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(384469) /Source="Nicolas_upshifts" /id="D156" /incds=0 /nref=46 /ntot=241 /MaxReadThrough="0.9216" /MaxDrop="4.25654" /score="8.42655219" /energy="-14.3" /TU="U270" /idTUdmin="U271" /TUdmin=18 /isTUend="TRUE" /label="downshifts" upshifts complement(384487) /Source="Nicolas_upshifts" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(385018..385037) /Source="Nicolas_upshift_promotors" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(385020) /Source="Nicolas_upshifts" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(385043..385981) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388237.2" /db_xref="EnsemblGenomes-Gn:BSU03550" /db_xref="EnsemblGenomes-Tr:CAB12149" /db_xref="GOA:Q08794" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10174" /db_xref="UniProtKB/Swiss-Prot:Q08794" /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRF TIAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGII QAAIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLIL LSALSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPF REPGFVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNES LAWYHLAGAVCIMIGVVGSNINLEKKTKRPGMPAKK*" /label="ycxC CDS" gene complement(385043..385981) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /label="ycxC gene" promotor_-10 complement(386020..386038) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(386027) /Source="Nicolas_upshifts" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(386054..386059) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 386105..387439 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 26585522; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388238.1" /db_xref="EnsemblGenomes-Gn:BSU03560" /db_xref="EnsemblGenomes-Tr:CAB12150" /db_xref="GOA:Q08792" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10175" /db_xref="UniProtKB/Swiss-Prot:Q08792" /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVI RALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCI NKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCA MPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFF YTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSS HVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGM YGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASR VIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL*" /label="ycxD CDS" gene 386105..387439 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /label="ycxD gene" CDS complement(387434..387601) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="C-terminal part of 4'-phosphopantetheinyl transferase (Surfactin synthetase-activating enzyme)" /db_xref="PSEUDO:CAX52545.1" /translation="MRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPE DITMVSYEELL*" /label="sfpAc CDS" gene complement(387434..387601) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /pseudo /label="sfpAc gene" CDS complement(387612..388109) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="N-terminal part of 4'-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme)" /db_xref="GOA:P39135" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1QR0" /db_xref="PDB:2GE0" /db_xref="PDB:2GE1" /db_xref="PDB:4MRT" /db_xref="PSEUDO:CAB12151.2" /db_xref="SubtiList:BG10176" /db_xref="UniProtKB/Swiss-Prot:P39135" /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRT LLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQ PIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQGRQR LIASA*" /label="sfpAn CDS" gene complement(387612..388109) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /pseudo /label="sfpAn gene" misc_feature complement(388136..388155) /Source="Nicolas_upshift_promotors" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(388148) /Source="Nicolas_upshifts" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" CDS complement(388214..388861) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /function="15.11: Biosynthesis of natural products" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17827323, 14762003, 16707694, 17827323, 25288929; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein regulating antibiotic production" /protein_id="NP_388240.2" /db_xref="EnsemblGenomes-Gn:BSU03580" /db_xref="EnsemblGenomes-Tr:CAB12152" /db_xref="GOA:O34927" /db_xref="SubtiList:BG12779" /db_xref="UniProtKB/Swiss-Prot:O34927" /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSL FQHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALST YTGSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTI LFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH*" /label="yczE CDS" gene complement(388214..388861) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /label="yczE gene" promotor_-10 complement(388890..388909) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(388893) /Source="Nicolas_upshifts" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(388925..388929) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(389030..389181) /Source="Nicolas_S_feature" /locus_tag="new_409056_409207_c" /HighExp="G180, G135, dia15, H2O2, Diami, S8, Oxctl, G150, LPhT, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S127" CDS complement(389182..389925) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 16513748, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 16513748, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (ATP-binding protein)" /protein_id="NP_388241.2" /db_xref="EnsemblGenomes-Gn:BSU03590" /db_xref="EnsemblGenomes-Tr:CAB12153" /db_xref="GOA:P39456" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11185" /db_xref="UniProtKB/Swiss-Prot:P39456" /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLL RCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENV MEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPE LMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVI VEQGPPEQIFSAPKEERTQRFLNRILNPL*" /label="tcyC CDS" gene complement(389182..389925) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /label="tcyC gene" downshifts complement(389238) /Source="Nicolas_upshifts" /id="D157" /incds=0 /nref=72 /ntot=232 /MaxReadThrough="4.60958" /MaxDrop="4.44283" /score="1.62131565" /energy="-12.6" /TU="U275" /idTUdmin="U276" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(389939..390643) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 15849754, 16850406, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 15849754, 16850406, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (permease)" /protein_id="NP_388242.1" /db_xref="EnsemblGenomes-Gn:BSU03600" /db_xref="EnsemblGenomes-Tr:CAB12154" /db_xref="GOA:P42200" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11186" /db_xref="UniProtKB/Swiss-Prot:P42200" /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFI FGMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFP SAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLS LVQHVIERRLDRYVAK*" /label="tcyB CDS" gene complement(389939..390643) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /label="tcyB gene" CDS complement(390630..391436) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (substrate-binding lipoprotein)" /protein_id="NP_388243.2" /db_xref="EnsemblGenomes-Gn:BSU03610" /db_xref="EnsemblGenomes-Tr:CAB12155" /db_xref="GOA:P42199" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11187" /db_xref="UniProtKB/Swiss-Prot:P42199" /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKK GVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLN SKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAF ETGEPQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK*" /label="tcyA CDS" gene complement(390630..391436) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /label="tcyA gene" promotor_-10 complement(391485..391504) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(391497) /Source="Nicolas_upshifts" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(391518..391525) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(391552..392424) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17295427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17295427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="HTH-type transcriptional regulator BsdA (LysR family)" /protein_id="NP_388244.1" /db_xref="EnsemblGenomes-Gn:BSU03620" /db_xref="EnsemblGenomes-Tr:CAB12156" /db_xref="GOA:P94403" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12022" /db_xref="UniProtKB/Swiss-Prot:P94403" /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELG VVLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYC AALMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQL DDIPCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPR IVCECHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTD SYLPKPAQQFLDLF*" /label="bsdA CDS" gene complement(391552..392424) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /label="bsdA gene" promotor_-10 complement(392162..392180) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(392169) /Source="Nicolas_upshifts" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(392195..392201) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 392478..392485 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(392493..392512) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-10" promotor_-10 392499..392518 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(392499) /Source="Nicolas_upshifts" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="upshifts" upshifts 392507 /Source="Nicolas_upshifts" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="upshifts" CDS 392514..393128 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10919793, 15979273, 17295427, 18388975, 26083743, 26658822, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase-flavin prenyltransferase subunit" /protein_id="NP_388245.1" /db_xref="EnsemblGenomes-Gn:BSU03630" /db_xref="EnsemblGenomes-Tr:CAB12157" /db_xref="GOA:P94404" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR004507" /db_xref="InterPro:IPR032901" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG12023" /db_xref="UniProtKB/Swiss-Prot:P94404" /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHL VVSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSL ASIRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMP AFYNRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA*" /label="ubiX CDS" gene 392514..393128 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /label="ubiX gene" promotor_-35 complement(392526..392533) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-35" CDS 393131..394552 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /EC_number="4.1.1.61" /EC_number="4.1.1.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11029449, 15979273, 17295427, 18388975, 26658822, 26337367; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phenolic acid decarboxylase subunit;1,4-dihydroxy-2-naphtoate-heptaprenyl diphosphatedecarboxylase" /protein_id="NP_388246.1" /db_xref="EnsemblGenomes-Gn:BSU03640" /db_xref="EnsemblGenomes-Tr:CAB12158" /db_xref="GOA:P94405" /db_xref="InterPro:IPR002830" /db_xref="InterPro:IPR012349" /db_xref="InterPro:IPR032902" /db_xref="SubtiList:BG12024" /db_xref="UniProtKB/Swiss-Prot:P94405" /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGD KSPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQN VGIYRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPL LYDQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTG HYSGGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPN EIVAVNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFN LPQVMWALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHY SQPLDSPLTTKEWEQKLMDLMNK*" /label="bsdC CDS" gene 393131..394552 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /label="bsdC gene" CDS 394569..394796 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /EC_number="4.1.1.91" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15979273, 17295427, 18388975, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase subunit" /protein_id="YP_003097675.1" /db_xref="EnsemblGenomes-Gn:BSU03651" /db_xref="EnsemblGenomes-Tr:CAX52546" /db_xref="GOA:C0H3U9" /db_xref="UniProtKB/Swiss-Prot:C0H3U9" /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESI TNPEKYNPAFKIDPKETETAIEVPAVPERKA*" /label="bsdD CDS" gene 394569..394796 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /label="bsdD gene" CDS 394793..395257 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15979273, 18388975; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN-binding enzyme subunit" /protein_id="NP_388247.2" /db_xref="EnsemblGenomes-Gn:BSU03652" /db_xref="EnsemblGenomes-Tr:CAB12159" /db_xref="GOA:C0SPB5" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12025" /db_xref="UniProtKB/Swiss-Prot:C0SPB5" /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMI SAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKD AEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR*" /label="yclD CDS" gene 394793..395257 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /label="yclD gene" downshifts 395238 /Source="Nicolas_upshifts" /id="D158" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="3.32586" /MaxDrop="3.88166" /score="45.8937489" /energy="-15.1" /TU="NA" /idTUdmin="U278" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 395264..395265 /Source="Nicolas_upshift_promotors" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 395265 /Source="Nicolas_upshifts" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 395324..396169 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388248.2" /db_xref="EnsemblGenomes-Gn:BSU03660" /db_xref="EnsemblGenomes-Tr:CAB12160" /db_xref="GOA:P94407" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12026" /db_xref="UniProtKB/Swiss-Prot:P94407" /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQ KYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMAL EYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDID KDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLA DVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFR KWLDQ*" /label="yclE CDS" gene 395324..396169 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /label="yclE gene" CDS complement(396209..397687) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8458848, 11717292, 15849754, 16204487, 16850406, 17496096, 23144141, 25966844; Product type t: transporter" /codon_start=1 /transl_table=11 /product="di-tripeptide-proton ABC symporter" /protein_id="NP_388249.2" /db_xref="EnsemblGenomes-Gn:BSU03670" /db_xref="EnsemblGenomes-Tr:CAB12175" /db_xref="GOA:P94408" /db_xref="InterPro:IPR000109" /db_xref="InterPro:IPR005279" /db_xref="InterPro:IPR018456" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12027" /db_xref="UniProtKB/Swiss-Prot:P94408" /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRA ILLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGG IFIMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSI FYMGINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNV PNPLSKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFT SKKADKTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWF QSLNPLFVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEAL VSPLWLVLSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQV AGLFDKIPETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL*" /label="dtpT CDS" gene complement(396209..397687) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /label="dtpT gene" downshifts complement(396217) /Source="Nicolas_upshifts" /id="D159" /incds=0 /nref=17 /ntot=90 /MaxReadThrough="1.40624" /MaxDrop="3.91827" /score="43.5753464" /energy="-21" /TU="NA" /idTUdmin="U281" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 397714..397716 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(397715..397734) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 397725 /Source="Nicolas_upshifts" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 397733..397751 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(397735) /Source="Nicolas_upshifts" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(397737..>397920) /Source="Nicolas_S_feature" /locus_tag="new_417763_418267_c" /HighExp="S3, S4, LoTm, S5, S6, T5.0H, T4.0H, M9-stat, S8, T3.30H" /AntisenseName="yclG" /AntisenseCor="0.33937447534762299" /AntisenseRegPval="-7.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S128" promotor_-35 complement(397749..397756) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 397905..397914 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 397920..397921 /note_="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_011" downshifts 397926 /Source="Nicolas_upshifts" /id="D172" /incds=0 /nref=173 /ntot=262 /MaxReadThrough="0.52252" /MaxDrop="5.32898" /score="20.7855667" /energy="-7.4" /TU="NA" /idTUdmin="U297" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(397936..399375) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /experiment="publication(s) with functional evidences, PMID:15223311, 24127574, 25388514, 27640111, 28348215, 28412355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)" /protein_id="NP_388271.1" /db_xref="EnsemblGenomes-Gn:BSU03890" /db_xref="EnsemblGenomes-Tr:CAB12197" /db_xref="GOA:P94426" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4MGR" /db_xref="PDB:4N0B" /db_xref="PDB:4TV7" /db_xref="PDB:5T4J" /db_xref="PDB:5T4K" /db_xref="PDB:5X03" /db_xref="SubtiList:BG12042" /db_xref="UniProtKB/Swiss-Prot:P94426" /translation="MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRE LAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEI HIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITR LISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQ VKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYI IEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYK QRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTV KGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFA RLKEEDIQEGVQRLFKAVYGHKKIPVTGD*" /label="gabR CDS" gene complement(397936..399375) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /label="gabR gene" promotor_-10 complement(398260..398271) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(398266) /Source="Nicolas_upshifts" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(398285..398291) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(399418..399437) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 399419..399426 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(399425) /Source="Nicolas_upshifts" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 399440..399459 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399444 /Source="Nicolas_upshifts" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(399448..399455) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 399482..400792 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /EC_number="2.6.1.19" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-aminobutyrate aminotransferase" /protein_id="NP_388272.1" /db_xref="EnsemblGenomes-Gn:BSU03900" /db_xref="EnsemblGenomes-Tr:CAB12198" /db_xref="GOA:P94427" /db_xref="InterPro:IPR004632" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12043" /db_xref="UniProtKB/Swiss-Prot:P94427" /translation="MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDL DGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGI APGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKP YKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVM EPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDL ITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLN ERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAY ANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA*" /label="gabT CDS" gene 399482..400792 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /label="gabT gene" promotor_-35 400670..400676 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 400690..400708 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 400698 /Source="Nicolas_upshifts" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 400794..400801 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 400816..400835 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 400825 /Source="Nicolas_upshifts" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" CDS 400861..402249 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /EC_number="1.2.1.24" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate-semialdehyde dehydrogenase" /protein_id="NP_388273.1" /db_xref="EnsemblGenomes-Gn:BSU03910" /db_xref="EnsemblGenomes-Tr:CAB12199" /db_xref="GOA:P94428" /db_xref="InterPro:IPR010102" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="SubtiList:BG12044" /db_xref="UniProtKB/Swiss-Prot:P94428" /translation="MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKT SANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKR VYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAP DTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKIL MKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHE SIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAG GTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPY GLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIE PYLETKYLSIGL*" /label="gabD CDS" gene 400861..402249 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /label="gabD gene" downshifts 402257 /Source="Nicolas_upshifts" /id="D173" /incds=0 /nref=107 /ntot=240 /MaxReadThrough="0.105510000000001" /MaxDrop="6.52053" /score="38.677658" /energy="-19.9" /TU="NA" /idTUdmin="U301" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 402307..402313 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 402327..402338 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 402328 /Source="Nicolas_upshifts" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="upshifts" CDS 402372..403235 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438764, 15849754, 16850406, 19054326, 21564334, 27329749; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose uptake protein" /protein_id="NP_388274.1" /db_xref="EnsemblGenomes-Gn:BSU03920" /db_xref="EnsemblGenomes-Tr:CAB12200" /db_xref="GOA:P40420" /db_xref="InterPro:IPR010651" /db_xref="SubtiList:BG11066" /db_xref="UniProtKB/Swiss-Prot:P40420" /translation="MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIV IYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLF GVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVST LGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAG GNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAA AVFLGIAKTNS*" /label="glcU CDS" gene 402372..403235 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /label="glcU gene" CDS 403255..404040 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /EC_number="1.1.1.47" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2493633, 3141376, 6438057, 16912926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2493633, 3141376, 6438057, 16912926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="forespore glucose 1-dehydrogenase" /protein_id="NP_388275.1" /db_xref="EnsemblGenomes-Gn:BSU03930" /db_xref="EnsemblGenomes-Tr:CAB12201" /db_xref="GOA:P12310" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10545" /db_xref="UniProtKB/Swiss-Prot:P12310" /translation="MYPDLKGKVVAITGAASGLGKAMAIRFGKEQAKVVINYYSNKQD PNEVKEEVIKAGGEAVVVQGDVTKEEDVKNIVQTAIKEFGTLDIMINNAGLENPVPSH EMPLKDWDKVIGTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEVIPWPLFVHYAA SKGGIKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPKQKADVESMIPMGYI GEPEEIAAVAAWLASKEASYVTGITLFADGGMTQYPSFQAGRG*" /label="gdh CDS" gene 403255..404040 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /label="gdh gene" misc_feature 403360..403379 /Source="Nicolas_upshift_promotors" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 403360 /Source="Nicolas_upshifts" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 403448 /Source="Nicolas_upshifts" /id="D174" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.44884" /MaxDrop="2.47712" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U301" /TUdmin=1188 /isTUend="FALSE" /label="downshifts" downshifts 404042 /Source="Nicolas_upshifts" /id="D175" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="2.7861" /MaxDrop="4.2307" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U303" /TUdmin="-836" /isTUend="FALSE" /label="downshifts" CDS complement(404085..404699) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19168619, 22904286, 27010565, 26822828; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative membrane protein involved in copper intake" /protein_id="NP_388276.1" /db_xref="EnsemblGenomes-Gn:BSU03940" /db_xref="EnsemblGenomes-Tr:CAB12202" /db_xref="GOA:P94431" /db_xref="InterPro:IPR012533" /db_xref="SubtiList:BG12045" /db_xref="UniProtKB/Swiss-Prot:P94431" /translation="MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYT MKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQE GQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTD EHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA*" /label="cutI CDS" gene complement(404085..404699) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /label="cutI gene" downshifts complement(404096) /Source="Nicolas_upshifts" /id="D176" /incds=0 /nref=95 /ntot=219 /MaxReadThrough="0.879290000000001" /MaxDrop="6.67627" /score="21.5633403" /energy="-16" /TU="NA" /idTUdmin="U305" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(404712..406337) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15101989, 15849754, 16850406, 19168619, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 15849754, 16850406, 19168619, 22904286, 23012364; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper import permease subunit" /protein_id="NP_388277.2" /db_xref="EnsemblGenomes-Gn:BSU03950" /db_xref="EnsemblGenomes-Tr:CAB12203" /db_xref="GOA:C0SP95" /db_xref="InterPro:IPR007348" /db_xref="InterPro:IPR008457" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR032693" /db_xref="InterPro:IPR032694" /db_xref="SubtiList:BG12046" /db_xref="UniProtKB/Swiss-Prot:C0SP95" /translation="MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQ VEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEW NAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVF FHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIR ETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFT GHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSP WALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTR KQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSI SPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQD QNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN*" /label="cutJ CDS" gene complement(404712..406337) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /label="cutJ gene" CDS complement(406372..406944) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 22904286, 23012364; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of copper intake (CutR-Cu(+))" /protein_id="NP_388278.1" /db_xref="EnsemblGenomes-Gn:BSU03960" /db_xref="EnsemblGenomes-Tr:CAB12204" /db_xref="GOA:P94433" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR008719" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12047" /db_xref="UniProtKB/Swiss-Prot:P94433" /translation="MLPINRQQHILKWLKEEGSLRISDISARFGVSEMTVYRDVNQLV QSNQVIKTAGGITLPVRTPQTDHMCSYCLKPVNQAHSVQLITVNQDIEQLCCAHCAFL RYADKTEEVSHLICRDFLLQTTVSAGSAYFVVNAELNLHCCQPQAIPFATLDHAERFQ KGFGGAVCTFDQALEDMLQDRKKRCTCTKK*" /label="cutR CDS" gene complement(406372..406944) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /label="cutR gene" promotor_-10 complement(406966..406985) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(406981) /Source="Nicolas_upshifts" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(406999..407006) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 407066..407085 /Source="Nicolas_upshift_promotors" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 407078 /Source="Nicolas_upshifts" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="upshifts" CDS 407109..407462 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18307109, 27010565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative reductase or disulfide isomerase" /protein_id="NP_388279.1" /db_xref="EnsemblGenomes-Gn:BSU03970" /db_xref="EnsemblGenomes-Tr:CAB12205" /db_xref="GOA:P94434" /db_xref="SubtiList:BG12048" /db_xref="UniProtKB/Swiss-Prot:P94434" /translation="MKETPCPNCGKPLTGDMVRSSNVPCQFRCGHCRERLYEYKVSAP IMLVSLAAIVLLIYLLMLLRNAAGSVLPAVQHVPMAVFALVCAYPVFIVSERMIAKYV IQNGNIIYRGKRKGS*" /label="ycnL CDS" gene 407109..407462 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /label="ycnL gene" downshifts 407433 /Source="Nicolas_upshifts" /id="D177" /incds=0 /nref=136 /ntot=248 /MaxReadThrough="0.860829999999999" /MaxDrop="6.25982" /score="38.4886131" /energy="-13.4" /TU="NA" /idTUdmin="U306" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 407526..407533 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 407547..407566 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 407552 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="upshifts" S_feature 407562..407634 /Source="Nicolas_S_feature" /locus_tag="new_449651_449723" /HighExp="S0, dia5, Gly, G135, B60, T0.30H, BT, G180, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S132" CDS 407635..409071 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IICB component" /protein_id="NP_388280.2" /db_xref="EnsemblGenomes-Gn:BSU03981" /db_xref="EnsemblGenomes-Tr:CAB12206" /db_xref="GOA:P42956" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004718" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR029503" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11215" /db_xref="UniProtKB/Swiss-Prot:P42956" /translation="MQQQEQQQGGMKVKVQRFGSYLSGMIMPNIGAFIAWGIITALFI PAGWFPNEQLNTLVSPMITYLLPLLIAYTGGKMIYDHRGGVVGATAAIGVIVGSDIPM FLGAMIMGPLGGYLIKQTDKLFKDKVKQGFEMLINNFTAGIVGAALTILAFYAIGPVV LTLNKLLAAGVEVIVHANLLPVASVFVEPAKVLFLNNAINHGILSPIGIEQASQTGKS ILFLVEANPGPGLGILLAYMFFGKGSSKSTAPGAAIIHFFGGIHEIYFPYILMKPALI LAAIAGGASGLLTFTIFNAGLVAAASPGSIIALMAMTPRGGYFGVLAGVLVAAAVSFI VSAVILKSSKASEEDLAAATEKMQSMKGKKSQAAAALEAEQAKAEEASELSPESVNKI IFACDAGMGSSAMGASILRNKVKKAELDISVTNTAINNLPSDADIVITHKDLTDRAKA KLPNATHISVDNFLNSPKYDELIEKLKK*" /label="mtlA CDS" gene 407635..409071 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /label="mtlA gene" CDS 409096..409527 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IIA component" /protein_id="YP_003097678.1" /db_xref="EnsemblGenomes-Gn:BSU03982" /db_xref="EnsemblGenomes-Tr:CAX52549" /db_xref="GOA:C0H3V2" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR016152" /db_xref="UniProtKB/Swiss-Prot:C0H3V2" /translation="MQVLAKENIKLNQTVSSKEEAIKLAGQTLIDNGYVTEDYISKMF EREETSSTFMGNFIAIPHGTEEAKSEVLHSGISIIQIPEGVEYGEGNTAKVVFGIAGK NNEHLDILSNIAIICSEEENIERLISAKSEEDLIAIFNEVN*" /label="mtlF CDS" gene 409096..409527 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /label="mtlF gene" CDS 409529..410650 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /EC_number="1.1.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 22014119, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 22014119, 23279188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannitol-1-phosphate 5-dehydrogenase" /protein_id="NP_388281.2" /db_xref="EnsemblGenomes-Gn:BSU03990" /db_xref="EnsemblGenomes-Tr:CAB12207" /db_xref="GOA:P42957" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023027" /db_xref="InterPro:IPR023028" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11216" /db_xref="UniProtKB/Swiss-Prot:P42957" /translation="MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKK EYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIA EGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIV PIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHA VTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIG RFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPE AVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ*" /label="mtlD CDS" gene 409529..410650 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /label="mtlD gene" downshifts 410633 /Source="Nicolas_upshifts" /id="D178" /incds=0 /nref=46 /ntot=156 /MaxReadThrough="5.56503" /MaxDrop="4.72154" /score="32.3837677" /energy="-13.4" /TU="U307" /idTUdmin="U308" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-35 410679..410682 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-35" promotor_-10 410698..410717 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-10" upshifts 410700 /Source="Nicolas_upshifts" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="upshifts" CDS 410741..411805 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /EC_number="1.1.1.93" /EC_number="1.1.1.83" /EC_number="4.1.1.73" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10568751, 12356321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tartrate dehydrogenase" /protein_id="NP_388282.3" /db_xref="EnsemblGenomes-Gn:BSU04000" /db_xref="EnsemblGenomes-Tr:CAB12208" /db_xref="GOA:P42958" /db_xref="InterPro:IPR011829" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG11222" /db_xref="UniProtKB/Swiss-Prot:P42958" /translation="MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTA FPWSCDYYLEHGKMMPEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELE LSINMRPAKQMAGITSPLLHPNDFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVF TRKATERVMRFAFELAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ HIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMF EPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVMEQVTADGIKTRDI GGQSTTAEVTDEICSRLRKL*" /label="ycsA CDS" gene 410741..411805 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /label="ycsA gene" promotor_-35 410975..410983 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 410997..411016 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 411007 /Source="Nicolas_upshifts" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 411799 /Source="Nicolas_upshifts" /id="D179" /incds=0 /nref=7 /ntot=41 /MaxReadThrough="4.24123" /MaxDrop="4.42639" /score="9.70532694" /energy="-11.6" /TU="U307,U308" /idTUdmin="U308" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 411872..411879 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 411892..411911 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 411905 /Source="Nicolas_upshifts" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 411940..412503 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11856304, 14568161" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11856304, 14568161; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388283.1" /db_xref="EnsemblGenomes-Gn:BSU04010" /db_xref="EnsemblGenomes-Tr:CAB12209" /db_xref="GOA:P42959" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11223" /db_xref="UniProtKB/Swiss-Prot:P42959" /translation="MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEG SSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKN DQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNG MGMPSEDDIIGTESLVFYPFGEMRQAK*" /label="sipU CDS" gene 411940..412503 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /label="sipU gene" S_feature 412504..413228 /Source="Nicolas_S_feature" /locus_tag="new_454593_455317" /HighExp="G150, Oxctl, Lbexp, G135, Paraq, dia0, LBGexp, Mt0, G180, dia15" /AntisenseName="yczH" /AntisenseCor="0.134432865921808" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S133" CDS complement(412563..413171) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388284.2" /db_xref="EnsemblGenomes-Gn:BSU04020" /db_xref="EnsemblGenomes-Tr:CAB12210" /db_xref="GOA:O31482" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12782" /db_xref="UniProtKB/Swiss-Prot:O31482" /translation="MFPKPLVILAHEIYGVNSHMKKMGRLIKMAGYDVLTPNLLGEDE VYTLKEEKTAYEQFTKHERLKTGETIIQNVIRQNAGRHIFVIGFSVGATIAWKCSSMP EVSGSVCYYGSRIRDSLHHMPACPVLLFFPNYEPSFDVALLIKKLREKQHTHLEIYQF DALHGFANPDSVYFNRALFFKTLSIIKNGAESRLRTVSSSFF*" /label="yczH CDS" gene complement(412563..413171) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /label="yczH gene" misc_feature complement(413189..413208) /Source="Nicolas_upshift_promotors" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 413205..413211 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(413212) /Source="Nicolas_upshifts" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 413224..413243 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 413230 /Source="Nicolas_upshifts" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 413257..413649 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16291680, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacyl-(acyl carrier protein) dehydratase" /protein_id="NP_388285.2" /db_xref="EnsemblGenomes-Gn:BSU04030" /db_xref="EnsemblGenomes-Tr:CAB12211" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11225" /db_xref="UniProtKB/Swiss-Prot:P42961" /translation="MNSLSLPHRYPFLFIDGVTDSEPGKHAAAYKLISENDWFITDTQ TEMPFSLVIEALAQTAAFTGITDENSLGLLSSVKKAEKLGEAVPGDRLDLTFEVTRNR RGFVFGHAKASVGEQPVAEAEIGIYIEK*" /label="ycsD CDS" gene 413257..413649 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /label="ycsD gene" downshifts 413626 /Source="Nicolas_upshifts" /id="D180" /incds=0 /nref=23 /ntot=189 /MaxReadThrough="1.8721" /MaxDrop="3.42324" /score="-5.4921522" /energy="-13.6" /TU="NA" /idTUdmin="U310" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(413682..413846) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097679.1" /db_xref="EnsemblGenomes-Gn:BSU04039" /db_xref="EnsemblGenomes-Tr:CAX52550" /db_xref="UniProtKB/Swiss-Prot:C0H3V3" /translation="MTEKKQQNKPNENPEHNDLTDPIPNEELKENMNDEKHKRQQRDN SQSERDYDTK*" /label="yczO CDS" gene complement(413682..413846) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /label="yczO gene" downshifts complement(413702) /Source="Nicolas_upshifts" /id="D181" /incds=0 /nref=101 /ntot=193 /MaxReadThrough="1.44096" /MaxDrop="6.55741" /score="22.582242" /energy="-10.6" /TU="NA" /idTUdmin="U313" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(413856..413874) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(413878) /Source="Nicolas_upshifts" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(413889..413895) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 413908..413915 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413929..413948 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 413932 /Source="Nicolas_upshifts" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="upshifts" CDS 413979..414728 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208, 27435445, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase / 5' nucleotidase" /protein_id="NP_388286.2" /db_xref="EnsemblGenomes-Gn:BSU04040" /db_xref="EnsemblGenomes-Tr:CAB12212" /db_xref="GOA:P42962" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11226" /db_xref="UniProtKB/Swiss-Prot:P42962" /translation="MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGV YVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDL RNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEI TNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMG NAQDIVKETADYITDTNIEDGVAKAIRHWVL*" /label="ribZ CDS" gene 413979..414728 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /label="ribZ gene" downshifts 414705 /Source="Nicolas_upshifts" /id="D182" /incds=0 /nref=219 /ntot=253 /MaxReadThrough="3.23506" /MaxDrop="6.84998" /score="19.5535298" /energy="-11.7" /TU="NA" /idTUdmin="U314" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(414781) /Source="Nicolas_upshifts" /id="D183" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="0.52326" /MaxDrop="2.84763" /score="25.9755124" /energy="-11.7" /TU="NA" /idTUdmin="U313" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" promotor_-35 414811..414817 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 414831..414850 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 414837..414933 /Source="Nicolas_S_feature" /locus_tag="new_456926_457022" /HighExp="S1, Cold, S0, GM 5, BMM, MG 25, Lbtran, aero, GM 10, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S134" upshifts 414837 /Source="Nicolas_upshifts" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 414934..415707 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxoprolinase subunit A" /protein_id="NP_388287.3" /db_xref="EnsemblGenomes-Gn:BSU04050" /db_xref="EnsemblGenomes-Tr:CAB12213" /db_xref="GOA:P42963" /db_xref="InterPro:IPR005501" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG11227" /db_xref="UniProtKB/Swiss-Prot:P42963" /translation="MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPS VMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAE GLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQ TANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKA DTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST*" /label="pxpA CDS" gene 414934..415707 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /label="pxpA gene" CDS 415722..416936 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9334321, 15849754, 16850406, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-oxoproline transporter" /protein_id="NP_388288.3" /db_xref="EnsemblGenomes-Gn:BSU04060" /db_xref="EnsemblGenomes-Tr:CAB12214" /db_xref="GOA:P42964" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG11228" /db_xref="UniProtKB/Swiss-Prot:P42964" /translation="MEQQKKTAGKKAGSWSLLMGAAFLMATSAIGPGFLTQTATFTNT LAASFGFVILISIILDIFAQTNVWRIIAVSGKRGQEIANMVLPGLGYFIAILVVLGGL AFNIGNIGGAGLGLQVLFGITPETGALISAVIAILIFVIKEAGKAMDRFTQIAGFVMI ILTVYVAATTAPPVGQAVANTFVPEHISIFAIVTLVGGTVGGYITFAGGHRLLDAGIK GKESIPQVTKSSVVGILITSVMRIALFLAVLGVVSKGLHIDESNPAASVFKLAAGNVG YKIFGLIMWSAAITSVIGAAYTSVSFFKTFSPKIEKNSRGIIIGFIVVSTLAFVTIGQ PAKILVLVGSLNGLILPIALGTLLVAAYKKNIVGDYKHPLWLTSTGALVVIVMAVMGI YTLCTQLPQLWS*" /label="pxpG CDS" gene 415722..416936 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /label="pxpG gene" CDS 416960..417733 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8186229, 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative D-5-oxoproline epimerase" /protein_id="NP_388289.3" /db_xref="EnsemblGenomes-Gn:BSU04070" /db_xref="EnsemblGenomes-Tr:CAB12215" /db_xref="GOA:P42966" /db_xref="InterPro:IPR009906" /db_xref="InterPro:IPR016938" /db_xref="SubtiList:BG11230" /db_xref="UniProtKB/Swiss-Prot:P42966" /translation="MAPKDVRALIREGKINGPTAGMSGGYAQANLVVLKKDLAFDFLL FCQRNQKPCPVLDVTEAGSPVPSLAAPDADIRTDFPKYRIYRHGILTEEVSDITPYWE DDFVGFLIGCSFSFEQALINNGIAVRHIDEGTNVSMYKTNIDCVPAGAFHGQMVVSMR PVPERLAVRAAQVTSRFPAVHGGPIHIGNPGAIGIRDLGKPDFGDAVSIRDGEVPVFW ACGVTPQAVAMNVKPEMVITHAPGHMLITDIRDESLAVL*" /label="pxpI CDS" gene 416960..417733 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /label="pxpI gene" CDS 417778..418500 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /EC_number="3.5.2.9" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit B" /protein_id="NP_388290.2" /db_xref="EnsemblGenomes-Gn:BSU04080" /db_xref="EnsemblGenomes-Tr:CAB12216" /db_xref="GOA:P60495" /db_xref="InterPro:IPR003833" /db_xref="InterPro:IPR010016" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR029000" /db_xref="PDB:2KWA" /db_xref="PDB:2ZP2" /db_xref="SubtiList:BG11231" /db_xref="UniProtKB/Swiss-Prot:P60495" /translation="MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFP GFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIV EIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRI AAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRA GDIVKFVRISEKDYHAYKEESN*" /label="pxpB CDS" gene 417778..418500 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /label="pxpB gene" CDS 418503..419510 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit C" /protein_id="YP_054571.2" /db_xref="EnsemblGenomes-Gn:BSU04090" /db_xref="EnsemblGenomes-Tr:CAE01447" /db_xref="GOA:Q7WY77" /db_xref="InterPro:IPR003778" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG14193" /db_xref="UniProtKB/Swiss-Prot:Q7WY77" /translation="MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIG NGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVS FGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALS QTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYE EAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTG GYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWL T*" /label="pxpC CDS" gene 418503..419510 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /label="pxpC gene" downshifts 418996 /Source="Nicolas_upshifts" /id="D184" /incds=1 /nref=6 /ntot=27 /MaxReadThrough="5.04721" /MaxDrop="4.5277" /score="-7.2426149" /energy="-12.4" /TU="U315" /idTUdmin="U315" /TUdmin="-1975" /isTUend="FALSE" /label="downshifts" promotor_no_box 419090..419190 /Source="Nicolas_upshift_promotors" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 419150 /Source="Nicolas_upshifts" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 419526..420278 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9334321; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the pxp operon (IclR family)" /protein_id="NP_388291.2" /db_xref="EnsemblGenomes-Gn:BSU04100" /db_xref="EnsemblGenomes-Tr:CAB12217" /db_xref="GOA:P42968" /db_xref="InterPro:IPR005471" /db_xref="InterPro:IPR014757" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11214" /db_xref="UniProtKB/Swiss-Prot:P42968" /translation="MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMV SSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLI MRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTEL ISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIA GFEARFTEDRLPYLTEKVKDAALQISRKIGYT*" /label="pxpR CDS" gene 419526..420278 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /label="pxpR gene" promotor_-35 420276..420285 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 420299..420318 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 420309 /Source="Nicolas_upshifts" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 420342..420983 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /EC_number="3.1.1.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 17220230, 20057119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 17220230, 20057119; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat phospholipase B" /protein_id="NP_388292.1" /db_xref="EnsemblGenomes-Gn:BSU04110" /db_xref="EnsemblGenomes-Tr:CAB12218" /db_xref="GOA:P42969" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11232" /db_xref="UniProtKB/Swiss-Prot:P42969" /translation="MVLRYTALGDSLTTGRGSGLFSPGFVQRFGDMMEADLKTRTAIN IFARSGLNTEEILGLLSYPYVQKCIRDADMITITGCGNDLIDSVLAYQTSKDETIFSR VSAHCHENFEKMIAKVAEIKGENPSPYAIRVFNLYNPFPEIDIAGKWITSFNSHLETL ASAPHVKIADAYSIFKGKEQEYLSFDGVHPNSKGYQAMAEAVHKLGYKELSVS*" /label="lipC CDS" gene 420342..420983 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /label="lipC gene" downshifts 420969 /Source="Nicolas_upshifts" /id="D185" /incds=0 /nref=106 /ntot=223 /MaxReadThrough="0.550230000000001" /MaxDrop="6.63515" /score="26.7371783" /energy="-11.8" /TU="NA" /idTUdmin="U315" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(420981..421406) /Source="Nicolas_S_feature" /locus_tag="new_463070_463495_c" /HighExp="S1, Sw, BC, S2, Lbtran, M0t90, LPhT, BI, M40t45, C90" /AntisenseName="yczI" /AntisenseCor="-0.57558682544748696" /AntisenseRegPval="-24.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S135" downshifts complement(421026) /Source="Nicolas_upshifts" /id="D186" /incds=0 /nref=171 /ntot=252 /MaxReadThrough="1.91715" /MaxDrop="5.13764" /score="6.4765859" /energy="-11.8" /TU="NA" /idTUdmin="U319" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 421059..421065 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421079..421098 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421080 /Source="Nicolas_upshifts" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="upshifts" CDS 421156..421401 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388293.1" /db_xref="EnsemblGenomes-Gn:BSU04120" /db_xref="EnsemblGenomes-Tr:CAB12219" /db_xref="GOA:P42970" /db_xref="InterPro:IPR025018" /db_xref="SubtiList:BG12783" /db_xref="UniProtKB/Swiss-Prot:P42970" /translation="MFRIFKMSFAVIIIILALIAFNYTEHTSVIQSVMLVFLGAVMFM QGLEERKKENDGSGAFNIYTAVFVWSVSLIGFTLHII*" /label="yczI CDS" gene 421156..421401 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /label="yczI gene" S_feature 421402..421812 /Source="Nicolas_S_feature" /locus_tag="new_463491_463901" /HighExp="T5.0H, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, M9-stat, T-4.40H, T-3.40H" /AntisenseName="yczJ" /AntisenseCor="-0.20847541933848601" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S136" CDS complement(421407..421694) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388294.1" /db_xref="EnsemblGenomes-Gn:BSU04130" /db_xref="EnsemblGenomes-Tr:CAB12220" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12784" /db_xref="UniProtKB/Swiss-Prot:O31484" /translation="MVREAAMLHIKEGLEQEFEDAFRQAAPIISGMKGYITHSLSKCM EETHKYLLLVEWETLEDHTEGFRGSSEYQEWKALLHRFYTPFPTVEHFQDV*" /label="yczJ CDS" gene complement(421407..421694) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /label="yczJ gene" misc_feature complement(421715..421734) /Source="Nicolas_upshift_promotors" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(421731) /Source="Nicolas_upshifts" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 421788..421792 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421809..421828 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421814 /Source="Nicolas_upshifts" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 421845..423851 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8830698, 10648534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830698, 10648534; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="penicillin-binding lipoprotein 3; transpeptidase" /protein_id="NP_388295.1" /db_xref="EnsemblGenomes-Gn:BSU04140" /db_xref="EnsemblGenomes-Tr:CAB12221" /db_xref="GOA:P42971" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR007887" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR032710" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11234" /db_xref="UniProtKB/Swiss-Prot:P42971" /translation="MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFD DMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYK VSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRG QIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVK DDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEEL KKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLT IDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNK DKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSV TRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKS SIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADV WHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGT ENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN*" /label="pbpC CDS" gene 421845..423851 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /label="pbpC gene" S_feature 423852..423952 /Source="Nicolas_S_feature" /locus_tag="new_465941_466041" /HighExp="LBGstat, T5.0H, M0t45, T3.30H, S0, LBGtran, Oxctl, T4.0H, C30, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.946, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S137" CDS 423953..424855 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388296.1" /db_xref="EnsemblGenomes-Gn:BSU04150" /db_xref="EnsemblGenomes-Tr:CAB12222" /db_xref="GOA:P42972" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11235" /db_xref="UniProtKB/Swiss-Prot:P42972" /translation="MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGI TTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTS KSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNF KDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVF TENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAIN ALSYKLDQDQWFRIFTAVQGYDIP*" /label="ycsN CDS" gene 423953..424855 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /label="ycsN gene" downshifts 424835 /Source="Nicolas_upshifts" /id="D187" /incds=0 /nref=48 /ntot=206 /MaxReadThrough="3.20352" /MaxDrop="4.57855" /score="1.36962171" /energy="-10.6" /TU="U320" /idTUdmin="U318" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 424928..424935 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424949..424968 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 424953..425040 /Source="Nicolas_S_feature" /locus_tag="new_467042_467129" /HighExp="S0, Gly, BC, Lbstat, S2, M9-stat, G135, dia5, T0.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S138" upshifts 424953 /Source="Nicolas_upshifts" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 425041..427125 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188, 24196428, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188, 24196428, 26159071; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, PTS-dependent activator" /protein_id="NP_388297.1" /db_xref="EnsemblGenomes-Gn:BSU04160" /db_xref="EnsemblGenomes-Tr:CAB12223" /db_xref="GOA:P96574" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG12049" /db_xref="UniProtKB/Swiss-Prot:P96574" /translation="MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSI KPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLES QEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKI VGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFS LSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGV TIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYS LYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDE IAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIE LKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSS KEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKD GLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGM DGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNR IFFTWMKEKNIL*" /label="mtlR CDS" gene 425041..427125 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /label="mtlR gene" downshifts 427112 /Source="Nicolas_upshifts" /id="D188" /incds=0 /nref=107 /ntot=220 /MaxReadThrough="1.91059" /MaxDrop="5.63565" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U321" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 427154..427160 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 427174..427192 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 427186 /Source="Nicolas_upshifts" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="upshifts" S_feature 427197..427278 /Source="Nicolas_S_feature" /locus_tag="new_469286_469367" /HighExp="Etha, S5, S6, ferm, S8, nit, S7, BT, Salt, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S139" promotor_-35 427240..427247 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 427261..427280 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 427280 /Source="Nicolas_upshifts" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="upshifts" CDS 427337..428848 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA ligase" /protein_id="NP_388298.2" /db_xref="EnsemblGenomes-Gn:BSU04170" /db_xref="EnsemblGenomes-Tr:CAB12224" /db_xref="GOA:P96575" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG12050" /db_xref="UniProtKB/Swiss-Prot:P96575" /translation="METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAM LQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKA MFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDT ALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIM LGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVI LMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVK VKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDED GFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVK NGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS*" /label="ydaB CDS" gene 427337..428848 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /label="ydaB gene" downshifts 428832 /Source="Nicolas_upshifts" /id="D189" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.57376" /MaxDrop="3.70168" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U323" /TUdmin=73 /isTUend="FALSE" /label="downshifts" CDS complement(428868..429413) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388299.1" /db_xref="EnsemblGenomes-Gn:BSU04180" /db_xref="EnsemblGenomes-Tr:CAB12225" /db_xref="GOA:P96576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12051" /db_xref="UniProtKB/Swiss-Prot:P96576" /translation="MIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQM LKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYT IWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIADFKAAGFEDID IQFKNIKPELSVCATAKKPAT*" /label="ydaC CDS" gene complement(428868..429413) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /label="ydaC gene" downshifts complement(428901) /Source="Nicolas_upshifts" /id="D190" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="1.44039" /MaxDrop="3.73662" /score="-9.35066962" /energy="-11.5" /TU="NA" /idTUdmin="U324" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(429480..429498) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(429494) /Source="Nicolas_upshifts" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(429513..429519) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 429555..429561 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-35" upshifts 429573 /Source="Nicolas_upshifts" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="upshifts" promotor_-10 429576..429594 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-10" CDS 429620..430480 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528, 21520290, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_388300.1" /db_xref="EnsemblGenomes-Gn:BSU04190" /db_xref="EnsemblGenomes-Tr:CAB12226" /db_xref="GOA:P80873" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12052" /db_xref="UniProtKB/Swiss-Prot:P80873" /translation="MANYPKELPAQTQSRQPGIESEMNPSPVYEYEDYKGADKLKGKV ALITGGDSGIGRAVSVAYAKEGADIAIVYKDEHEDAEETKKRVEQEGVKCLLIAGDVG EEEFCNEAVEKTVKELGGLDILVNNAGEQHPKESIKDITSEQLHRTFKTNFYSQFYLT KKAIDYLKPGSAIINTTSINPYVGNPTLIDYTATKGAINAFTRTMAQALVKDGIRVNA VAPGPIWTPLIPATFPEETVAQFGQDTPMGRPGQPVEHVGCYVLLASDESSYMTGQTL HVNGGNFVTT*" /label="ydaD CDS" gene 429620..430480 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /label="ydaD gene" CDS 430496..430999 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /EC_number="5.3.1.15" /experiment="publication(s) with functional evidences, PMID:10220166, 15805528, 21421786, 21520290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15805528, 21421786, 21520290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lyxose ketol isomerase" /protein_id="NP_388301.1" /db_xref="EnsemblGenomes-Gn:BSU04200" /db_xref="EnsemblGenomes-Tr:CAB12227" /db_xref="GOA:P96578" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:2Y0O" /db_xref="SubtiList:BG12053" /db_xref="UniProtKB/Swiss-Prot:P96578" /translation="MGITKEEVNSYYQKAGIVLTDEEVDQIQLMDYGLGKERKVGLQL FVYVNTDRYCSKELVLFPGQTCPEHRHPPVDGQEGKQETFRCRYGKVYLYVEGEKTPL PKVLPPQEDREHYTVWHEIELEPGGQYTIPPNTKHWFQAGEEGAVVTEMSSTSTDKHD IFTDPRI*" /label="lyxE CDS" gene 430496..430999 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /label="lyxE gene" downshifts 430980 /Source="Nicolas_upshifts" /id="D191" /incds=0 /nref=16 /ntot=26 /MaxReadThrough="4.81615" /MaxDrop="6.21035" /score="29.8440619" /energy="-15.5" /TU="U325" /idTUdmin="U325" /TUdmin="-683" /isTUend="FALSE" /label="downshifts" promotor_-35 431028..431035 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 431049..431068 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 431051 /Source="Nicolas_upshifts" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 431085..431636 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /EC_number="2.3.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15468321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal protein N-acetyltransferase" /protein_id="NP_388302.1" /db_xref="EnsemblGenomes-Gn:BSU04210" /db_xref="EnsemblGenomes-Tr:CAB12228" /db_xref="GOA:P96579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1NSL" /db_xref="SubtiList:BG12054" /db_xref="UniProtKB/Swiss-Prot:P96579" /translation="MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENP SSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAK EFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGL YVNGMHHDLVYYSLLKREWEGEK*" /label="ydaF CDS" gene 431085..431636 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /label="ydaF gene" promotor_-35 431651..431657 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 431672..431690 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 431685 /Source="Nicolas_upshifts" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 431714..432136 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_388303.1" /db_xref="EnsemblGenomes-Gn:BSU04220" /db_xref="EnsemblGenomes-Tr:CAB12229" /db_xref="GOA:P80238" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG19017" /db_xref="UniProtKB/Swiss-Prot:P80238" /translation="MNQQDIKQKVLDVLDHHKVGSLATVQKGKPHSRYMTFFHDGLTI YTPTSKETHKAEEIENNPNVHILLGYDCEGFGDAYVEVAGKAKINNSAELKDKIWSSK LERWFDGKDDPNLVILEIEPEDIRLMNAGEKTPVSLEL*" /label="ydaG CDS" gene 431714..432136 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /label="ydaG gene" promotor_-35 432141..432149 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 432160..432179 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 432179..432545 /Source="Nicolas_S_feature" /locus_tag="new_474268_474634" /HighExp="Etha, Salt, Cold, Sw, B60, Gly, M9-stat, LPhT, B36, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.999, 1" /TUlongSig="SigB" /TUlongPSig=1 /label="S140" upshifts 432179 /Source="Nicolas_upshifts" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(432205..432305) /Source="Nicolas_upshift_promotors" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" misc_RNA complement(432240..432508) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /product="small regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 23457461" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23457461; Product type n: RNA" /label="bsrC RNA" gene complement(432240..432508) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /label="bsrC gene" upshifts complement(432245) /Source="Nicolas_upshifts" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 432502 /Source="Nicolas_upshifts" /id="D192" /incds=0 /nref=124 /ntot=275 /MaxReadThrough="2.67264" /MaxDrop="7.35087" /score="29.9942993" /energy="-12" /TU="NA" /idTUdmin="U326" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 432582..432591 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 432604..432619 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 432609 /Source="Nicolas_upshifts" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 432642..433451 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_388304.1" /db_xref="EnsemblGenomes-Gn:BSU04230" /db_xref="EnsemblGenomes-Tr:CAB12230" /db_xref="GOA:P96581" /db_xref="InterPro:IPR021260" /db_xref="SubtiList:BG12055" /db_xref="UniProtKB/Swiss-Prot:P96581" /translation="MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSL FNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPS FVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKR LFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSV LADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF*" /label="amj CDS" gene 432642..433451 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /label="amj gene" downshifts 433432 /Source="Nicolas_upshifts" /id="D193" /incds=0 /nref=5 /ntot=103 /MaxReadThrough="2.92236" /MaxDrop="3.54247" /score="15.7032536" /energy="-14.9" /TU="U330" /idTUdmin="U327" /TUdmin=911 /isTUend="FALSE" /label="downshifts" CDS complement(433495..433785) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388305.1" /db_xref="EnsemblGenomes-Gn:BSU04240" /db_xref="EnsemblGenomes-Tr:CAB12231" /db_xref="GOA:O31485" /db_xref="InterPro:IPR023845" /db_xref="SubtiList:BG12807" /db_xref="UniProtKB/Swiss-Prot:O31485" /translation="MLHTPIGRLRTMGFIEGMSLLILLFIAMPLKYWAGLPLAVTIVG SVHGGLFILYLLVLAYATFSVKWPLKWSAAGFIAAFVPFGNFLYDRGLRNYK*" /label="ydzA CDS" gene complement(433495..433785) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /label="ydzA gene" downshifts complement(433499) /Source="Nicolas_upshifts" /id="D194" /incds=0 /nref=235 /ntot=260 /MaxReadThrough="1.23465" /MaxDrop="7.74945" /score="10.1798531" /energy="-14.9" /TU="NA" /idTUdmin="U332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(433813..433832) /Source="Nicolas_upshift_promotors" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 433813..433831 /Source="Nicolas_upshift_promotors" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 433819 /Source="Nicolas_upshifts" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(433829) /Source="Nicolas_upshifts" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 433907..433914 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 433928..433947 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 433932 /Source="Nicolas_upshifts" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 433970..434404 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9341680, 10606655, 10913073, 12458218, 16407330, 16528101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341680, 10606655, 10913073, 12458218, 16407330, 16528101; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388306.1" /db_xref="EnsemblGenomes-Gn:BSU04250" /db_xref="EnsemblGenomes-Tr:CAB12232" /db_xref="GOA:P96582" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2CFX" /db_xref="SubtiList:BG12056" /db_xref="UniProtKB/Swiss-Prot:P96582" /translation="MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLE SFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAAC YMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG*" /label="lrpC CDS" gene 433970..434404 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /label="lrpC gene" promotor_-35 434401..434404 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 434413 /Source="Nicolas_upshifts" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 434421..434440 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 434469..436652 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /EC_number="5.99.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16192570, 16556226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase III" /protein_id="NP_388307.1" /db_xref="EnsemblGenomes-Gn:BSU04260" /db_xref="EnsemblGenomes-Tr:CAB12233" /db_xref="GOA:P96583" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005738" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR034144" /db_xref="SubtiList:BG11979" /db_xref="UniProtKB/Swiss-Prot:P96583" /translation="MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGH LVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVI ATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSA VARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIR AAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDL TELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGME VKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIA KRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQ TLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGE TGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQ KLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVN GKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSV FEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK*" /label="topB CDS" gene 434469..436652 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /label="topB gene" downshifts 436635 /Source="Nicolas_upshifts" /id="D195" /incds=0 /nref=133 /ntot=245 /MaxReadThrough="3.22367" /MaxDrop="6.18597" /score="23.5229393" /energy="-10.4" /TU="U334" /idTUdmin="U333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 436701..436707 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 436722..436740 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 436723..436854 /Source="Nicolas_S_feature" /locus_tag="new_478812_478943" /HighExp="Etha, Salt, Heat, Cold, H2O2, G180, LPhT, Oxctl, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S141" upshifts 436723 /Source="Nicolas_upshifts" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="upshifts" CDS 436855..437943 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 26078454, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 26078454, 27897378; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase lipoprotein" /protein_id="NP_388308.1" /db_xref="EnsemblGenomes-Gn:BSU04270" /db_xref="EnsemblGenomes-Tr:CAB12234" /db_xref="GOA:O31486" /db_xref="InterPro:IPR008928" /db_xref="SubtiList:BG12057" /db_xref="UniProtKB/Swiss-Prot:O31486" /translation="MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPA EYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFL MSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYN MNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNG FLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGR YSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGY MSGTQTHSFDNLLPLLAERKLFNENIIQ*" /label="epsJ CDS" gene 436855..437943 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /label="epsJ gene" CDS 437924..438775 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23893111, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111, 27897378; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic-di-GMP receptor" /protein_id="NP_388309.1" /db_xref="EnsemblGenomes-Gn:BSU04280" /db_xref="EnsemblGenomes-Tr:CAB12235" /db_xref="GOA:P96585" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG12058" /db_xref="UniProtKB/Swiss-Prot:P96585" /translation="MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITF GVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLL FSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERY GNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIV LTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELEN EMMMNEL*" /label="epsK CDS" gene 437924..438775 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /label="epsK gene" CDS 438786..440495 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27897378; Product type ph :phenotype" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388310.1" /db_xref="EnsemblGenomes-Gn:BSU04290" /db_xref="EnsemblGenomes-Tr:CAB12236" /db_xref="GOA:O31487" /db_xref="InterPro:IPR018763" /db_xref="SubtiList:BG12059" /db_xref="UniProtKB/Swiss-Prot:O31487" /translation="MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVK MLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVV AIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFK ADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISP MSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGG SIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSY LEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQ VQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFE GGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQ VKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERR SLG*" /label="ydaL CDS" gene 438786..440495 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /label="ydaL gene" CDS 440488..441750 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /EC_number="2.4.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378, 28296273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase associated to biofilm formation" /protein_id="NP_388311.1" /db_xref="EnsemblGenomes-Gn:BSU04300" /db_xref="EnsemblGenomes-Tr:CAB12237" /db_xref="GOA:P96587" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12060" /db_xref="UniProtKB/Swiss-Prot:P96587" /translation="MGNTLFFISLSLIWVMLLYHMFLMQGGFRHYMTFERNIPKWREN MKELPKVSVLIPAHNEEVVIRQTLKAMVNLYYPKDRLEIIVVNDNSSDRTGDIVNEFS EKYDFIKMVITKPPNAGKGKSSALNSGFAESNGDVICVYDADNTPEKMAVYYLVLGLM NDEKAGAVVGKFRVINAAKTLLTRFINIETICFQWMAQGGRWKWFKIATIPGTNFAIR RSIIEKLGGWDDKALAEDTELTIRVYNLGYHIRFFPAAITWEQEPETWKVWWRQRTRW ARGNQYVVLKFLAQFFKLKRKRIIFDLFYFFFTYFLFFFGVIMSNAIFVVNLFYDLHL SVGFLAMILWILAFFLFMTEVMITLSIEKTEMNKQNFFIVFLMYFTYSQAWIVLVIYS LFVEIKHRLFKQEVKWYKTERYNQHKSG*" /label="ydaM CDS" gene 440488..441750 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /label="ydaM gene" CDS 441756..443867 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative regulator of exopolysaccharide synthesis" /protein_id="NP_388312.1" /db_xref="EnsemblGenomes-Gn:BSU04310" /db_xref="EnsemblGenomes-Tr:CAB12238" /db_xref="GOA:O31488" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR018513" /db_xref="SubtiList:BG12061" /db_xref="UniProtKB/Swiss-Prot:O31488" /translation="MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQ VLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPV KTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPD SRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKT VDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVL KAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLT LENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESAS QAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKE NNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVS QSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSD LLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEII SYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIM VVAAVFIWIAVRRKKRKTDTE*" /label="ydaN CDS" gene 441756..443867 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /label="ydaN gene" downshifts 443851 /Source="Nicolas_upshifts" /id="D196" /incds=0 /nref=18 /ntot=91 /MaxReadThrough="0.438479999999999" /MaxDrop="4.36576" /score="34.1370207" /energy="-9.9" /TU="NA" /idTUdmin="U336" /TUdmin="-4598" /isTUend="FALSE" /label="downshifts" promotor_-35 443964..443971 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 443986..444005 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 443993 /Source="Nicolas_upshifts" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 444003..444146 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /product="ATP-, cyclic di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 20511502, 23086297, 25086507, 25086509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 20511502, 23086297, 25086507, 25086509; Product type n: RNA" /function="16.3: Control" /label="swaO RNA" gene 444003..444146 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /label="swaO gene" downshifts 444144 /Source="Nicolas_upshifts" /id="D197" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="7.43698" /MaxDrop="5.83561" /score="30.4392599" /energy="-14.7" /TU="U336" /idTUdmin="U336" /TUdmin="-4305" /isTUend="FALSE" /label="downshifts" S_feature 444189..444342 /Source="Nicolas_S_feature" /locus_tag="new_486278_486431" /HighExp="LPhT, LBGstat, LPh, T-1.10H, T-0.40H, G135, G180, T-1.40H, G150, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S142" CDS 444343..446166 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cyclic di-AMP controlled transporter of potassium" /protein_id="NP_388313.1" /db_xref="EnsemblGenomes-Gn:BSU04320" /db_xref="EnsemblGenomes-Tr:CAB12239" /db_xref="GOA:P96589" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12062" /db_xref="UniProtKB/Swiss-Prot:P96589" /translation="MYHSIKRFLIGKPLKSQAAGEQKLTKLKALAMLSSDALSSVAYG TEQILIILATISAAAFWYSIPIAVGVLILLLALILSYRQIIYAYPQGGGAYIVSKENL GEKPGLIAGGSLLVDYILTVAVSISAGTDAITSAFPALHDYHVPIAIFLVLVIMILNL RGLSESASILAYPVYLFVVALLVLIAVGLFKLMTGQIDQPAHHTSLGTPVAGITLFLL LKAFSSGCSALTGVEAISNAIPAFKNPPARNAARTLAMMGILLAILFSGITVLAYGYG TAPKPDETVVSQIASETFGRNVFYYVIQGVTSLILVLAANTGFSAFPQLAFNLARDQY MPRMFTVRGDRLGFSNGIIFLGFASIVLIILFGGQTEHLIPLYAVGVFIPFTLSQTGM CMKWIKQKPKGWIGKMLINSCGALISFMVLSILFVTKFNVVWPVLIFMPIVVLLFFAI KNHYTAVGEQLRIVDKEPEEIKGTVVIVPVAGVTTVVQKSIHYAKSLSDQVIAVHVSF DREQEKKFEKRWEELNNGVRLVTLHSSYRSLVHPFDKFLETVEAKAKKEQFSVMVLFP QFITKKRWHTILHNQSAFLLRVRLFWKKDIMVATLPYHFKK*" /label="kimA CDS" gene 444343..446166 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /label="kimA gene" downshifts 446158 /Source="Nicolas_upshifts" /id="D198" /incds=0 /nref=50 /ntot=181 /MaxReadThrough="3.55206" /MaxDrop="4.7232" /score="6.00201196" /energy="-13.9" /TU="U336" /idTUdmin="U336" /TUdmin="-2291" /isTUend="FALSE" /label="downshifts" CDS 446225..446674 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /EC_number="3.6.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576788, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NTP pyrophosphohydrolase" /protein_id="NP_388314.1" /db_xref="EnsemblGenomes-Gn:BSU04330" /db_xref="EnsemblGenomes-Tr:CAB12240" /db_xref="GOA:P96590" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11956" /db_xref="UniProtKB/Swiss-Prot:P96590" /translation="MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEA AVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSP GRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK*" /label="nudT CDS" gene 446225..446674 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /label="nudT gene" promotor_-35 446687..446693 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 446708..446726 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 446709 /Source="Nicolas_upshifts" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="upshifts" CDS 446741..448465 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /EC_number="1.2.3.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291680, 16513748, 10220166, 23611909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-phosphate generating pyruvate oxidase" /protein_id="NP_388315.1" /db_xref="EnsemblGenomes-Gn:BSU04340" /db_xref="EnsemblGenomes-Tr:CAB12241" /db_xref="GOA:P96591" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12063" /db_xref="UniProtKB/Swiss-Prot:P96591" /translation="MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQL KFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAG QVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLS VSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAK RELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGT SFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFL NACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARH FKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVK YKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEE LAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSL KKSLKRLF*" /label="poxB CDS" gene 446741..448465 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /label="poxB gene" S_feature complement(447577..448436) /Source="Nicolas_S_feature" /locus_tag="new_489666_490525_c" /HighExp="H2O2, Paraq, G180, G150, Oxctl, Diami, dia15, G135, C30, dia5" /AntisenseName="ydaP" /AntisenseCor="-5.0529608261635599E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S143" S_feature complement(448438..448549) /Source="Nicolas_S_feature" /locus_tag="new_490527_490638_c" /HighExp="dia5, M0t45, S0, S2, S1, Paraq, GM 120, Lbstat, MG 5, UNK1" /AntisenseName="ydaP" /AntisenseCor="1.7026698118644101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S144" downshifts 448449 /Source="Nicolas_upshifts" /id="D199" /incds=0 /nref=50 /ntot=166 /MaxReadThrough="5.18566" /MaxDrop="6.66568" /score="7.55338633" /energy="-5.3" /TU="U337" /idTUdmin="U336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(448457..448660) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513943.1" /translation="MIRISMQGQMHLPLKQDAFVLLSVSSMAKSVPNTYTDHFMNSNM LKIHLFPKKKKKTRALRAPVFLK*" /label="hypothetical protein CDS" gene complement(448457..448660) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /label="gene" downshifts complement(448481) /Source="Nicolas_upshifts" /id="D200" /incds=0 /nref=5 /ntot=55 /MaxReadThrough="4.75809" /MaxDrop="8.06239" /score="11.2659249" /energy="-9.1" /TU="U338,U340,U341" /idTUdmin="U338" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(448509..448609) /Source="Nicolas_upshift_promotors" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 448518..448523 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 448540..448558 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(448549) /Source="Nicolas_upshifts" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature 448550..448765 /Source="Nicolas_S_feature" /locus_tag="new_490639_490854" /HighExp="Etha, S4, S8, S5, C30, S7, B60, S6, Salt, B36" /AntisenseName="ydzK" /AntisenseCor="3.8830946787094797E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigB" /TUshortPSig="0.914, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S145" upshifts 448550 /Source="Nicolas_upshifts" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(448616..448687) /Source="Nicolas_S_feature" /locus_tag="new_490705_490776_c" /HighExp="Sw, B60, dia15, dia5, BI, Etha, BC, M9-stat, C90, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S146" downshifts complement(448659) /Source="Nicolas_upshifts" /id="D201" /incds=0 /nref=21 /ntot=191 /MaxReadThrough="5.39949" /MaxDrop="5.81865" /score="3.34912028" /energy="-20.3" /TU="U340,U341" /idTUdmin="U343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(448688..448954) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_003097680.1" /db_xref="EnsemblGenomes-Gn:BSU04359" /db_xref="EnsemblGenomes-Tr:CAX52551" /db_xref="GOA:C0H3V4" /db_xref="UniProtKB/Swiss-Prot:C0H3V4" /translation="MSVFILFYLWIVPIVIGILCSVAAHKSKGKMRVAPGIAMIVLSI ISLITAFTAGHTNFHVFIGGMFLFGTFLVGSAFPFFFGLKKKEK*" /label="ydzK CDS" gene complement(448688..448954) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /label="ydzK gene" promotor_-10 complement(448970..448989) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(448988) /Source="Nicolas_upshifts" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(449001..449008) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(449058..450335) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton-coupled manganese transporter" /protein_id="NP_388317.1" /db_xref="EnsemblGenomes-Gn:BSU04360" /db_xref="EnsemblGenomes-Tr:CAB12243" /db_xref="GOA:P96593" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG12065" /db_xref="UniProtKB/Swiss-Prot:P96593" /translation="MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAY IDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFP KPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGA TVMPHAIYLHSALTQRRVVGKTDAERKKIFRFEFIDILIAMLIAGAINASMLIVAAAL FFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFIN YRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIM GSLINAKWITVVSWLIAVLIVALNVFLIVDTFR*" /label="mntH CDS" gene complement(449058..450335) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /label="mntH gene" downshifts complement(449077) /Source="Nicolas_upshifts" /id="D202" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="5.8826" /MaxDrop="4.8109" /score="28.3182556" /energy="-9.6" /TU="U341,U343" /idTUdmin="U342" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(450397..450416) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(450409) /Source="Nicolas_upshifts" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(450411..450488) /Source="Nicolas_S_feature" /locus_tag="new_492500_492577_c" /HighExp="S6, S8, S7, Etha, S5, Salt, BT, Heat, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S147" promotor_-35 complement(450429..450436) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(450472..450491) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(450488) /Source="Nicolas_upshifts" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(450505..450514) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(450565..450822) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388318.1" /db_xref="EnsemblGenomes-Gn:BSU04370" /db_xref="EnsemblGenomes-Tr:CAB12244" /db_xref="GOA:P96594" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG12066" /db_xref="UniProtKB/Swiss-Prot:P96594" /translation="MLSFLVSLVVAIVIGLIGSAIVGNRLPGGIFGSMIAGLIGAWIG HGLLGTWGPSLAGFAIFPAIIGAAIFVFLLGLIFRGLRKEA*" /label="ydaS CDS" gene complement(450565..450822) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /label="ydaS gene" downshifts complement(450573) /Source="Nicolas_upshifts" /id="D203" /incds=0 /nref=7 /ntot=33 /MaxReadThrough="4.70076" /MaxDrop="4.7213" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" downshifts complement(450639) /Source="Nicolas_upshifts" /id="D204" /incds=1 /nref=2 /ntot=69 /MaxReadThrough="7.55545" /MaxDrop="2.8244" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS complement(450900..451352) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388319.1" /db_xref="EnsemblGenomes-Gn:BSU04380" /db_xref="EnsemblGenomes-Tr:CAB12245" /db_xref="InterPro:IPR018691" /db_xref="SubtiList:BG12067" /db_xref="UniProtKB/Swiss-Prot:P96595" /translation="MPWSMKDYPASLKNLEKPVRKKAIDIANAMIDEGYEEGRAIPIA TSKAKEWAENASTDEIDDFLTHDDETERDADPSSGSGPELMNKAEHVIKHKKGWAVKA EGAKRVSEIKDTKKEAIERAKEIAAHKGTEVIVHLADGSVQRKIKTGS*" /label="ydaT CDS" gene complement(450900..451352) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /label="ydaT gene" promotor_-10 complement(451371..451389) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(451388) /Source="Nicolas_upshifts" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(451403..451409) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 451421 /Source="Nicolas_upshifts" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 451429..451448 /Source="Nicolas_upshift_promotors" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 451470..452288 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388320.1" /db_xref="EnsemblGenomes-Gn:BSU04390" /db_xref="EnsemblGenomes-Tr:CAB12246" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG12068" /db_xref="UniProtKB/Swiss-Prot:P96596" /translation="MPTERKEDLHQQLKEIEKWEKDQQKVWFWEKLSRLPFQLLDKLT PEFIQKKIGKLLDEVGSFVQTGGQYLTSEKQIIRMFQKKLPEEIFESLEDIRKAPLPV MDEIAEGMGKNRTNAATVQGATTGVGGVFTLAADIPAVLGLSLKTLQDIAVAYGYDPK EKKERVFIVKCLQLTSADVVGKRSILQELKHYDQDRTYKNVASQIQGWREVVLGYRDT FGWKKLFQIVPVAGMVFGAAANRSTLNDITETGMMLYKKRRILERLKETEREME*" /label="ydbA CDS" gene 451470..452288 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /label="ydbA gene" downshifts 452279 /Source="Nicolas_upshifts" /id="D205" /incds=0 /nref=118 /ntot=223 /MaxReadThrough="0.66117" /MaxDrop="4.41502" /score="5.38936313" /energy="-9.2" /TU="NA" /idTUdmin="U344" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 452356..452362 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 452376..452394 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 452384 /Source="Nicolas_upshifts" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="upshifts" CDS 452417..452788 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651322, 9669336, 9763714, 12562800, 21421783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651322, 9669336, 9763714, 12562800, 21421783; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein glucose starvation induced" /protein_id="NP_388321.1" /db_xref="EnsemblGenomes-Gn:BSU04400" /db_xref="EnsemblGenomes-Tr:CAB12247" /db_xref="InterPro:IPR019626" /db_xref="SubtiList:BG10826" /db_xref="UniProtKB/Swiss-Prot:P26907" /translation="MADNNKMSREEAGRKGGETTSKNHDKEFYQEIGQKGGEATSKNH DKEFYQEIGEKGGEATSKNHDKEFYQEIGEKGGEATSENHDKEFYQEIGRKGGEATSK NHDKEFYQEIGSKGGNARNND*" /label="gsiB CDS" gene 452417..452788 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /label="gsiB gene" downshifts complement(452421) /Source="Nicolas_upshifts" /id="D206" /incds=0 /nref=1 /ntot=25 /MaxReadThrough="1.50212" /MaxDrop="4.6705" /score="-7.76438364" /energy="-14.2" /TU="NA" /idTUdmin="U346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 452805 /Source="Nicolas_upshifts" /id="D207" /incds=0 /nref=153 /ntot=219 /MaxReadThrough="3.75525" /MaxDrop="8.3301" /score="39.7307477" /energy="-16.6" /TU="U345" /idTUdmin="U345" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" upshifts complement(452839) /Source="Nicolas_upshifts" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(452842..452845) /Source="Nicolas_upshift_promotors" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 452867..452874 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 452886..452905 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 452893 /Source="Nicolas_upshifts" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="upshifts" CDS 452920..453261 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_388322.1" /db_xref="EnsemblGenomes-Gn:BSU04410" /db_xref="EnsemblGenomes-Tr:CAB12248" /db_xref="GOA:P96597" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR019780" /db_xref="SubtiList:BG12069" /db_xref="UniProtKB/Swiss-Prot:P96597" /translation="MSKMQNLLAIANEVKEKHANFSISEVNDHCVRLAVFTGEYDWHH HPDSDELFIVLEGELLIDFKDKETAVLKANDSLLIPKGTVHRTRSYVRTVNLCVEHKQ AETVIIEEQPC*" /label="ydbB CDS" gene 452920..453261 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /label="ydbB gene" CDS 453255..453614 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388323.1" /db_xref="EnsemblGenomes-Gn:BSU04420" /db_xref="EnsemblGenomes-Tr:CAB12249" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR032555" /db_xref="SubtiList:BG12070" /db_xref="UniProtKB/Swiss-Prot:P96598" /translation="MLIKKMICEVDAANAEAFAKAQSQWEALSHISGFIKQAGGWRKT IDEPLTAEIISVWENREAYDHFMENEHDSIYEENDQKAVILSIEVTVYEEDKPFVHDL LHNPDIRYEPNWTVLKA*" /label="ydbC CDS" gene 453255..453614 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /label="ydbC gene" S_feature complement(453317..453610) /Source="Nicolas_S_feature" /locus_tag="new_495406_495699_c" /HighExp="Etha, Salt, M9-stat, C30, Heat, Sw, B60, S8, C90, UNK1" /AntisenseName="ydbC" /AntisenseCor="0.16172626521480701" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S148" downshifts 453555 /Source="Nicolas_upshifts" /id="D208" /incds=0 /nref=2 /ntot=130 /MaxReadThrough="1.8663" /MaxDrop="2.67081" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 453599 /Source="Nicolas_upshifts" /id="D209" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="0.252220000000001" /MaxDrop="2.61185" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(453651..454472) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /EC_number="1.11.1.6" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15231799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative manganese-containing catalase" /protein_id="NP_388324.1" /db_xref="EnsemblGenomes-Gn:BSU04430" /db_xref="EnsemblGenomes-Tr:CAB12250" /db_xref="GOA:P80878" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG12071" /db_xref="UniProtKB/Swiss-Prot:P80878" /translation="MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLF QGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSIL GGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLF EMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQL INFSEGEVSAEQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPFVHNTLPGRE*" /label="ydbD CDS" gene complement(453651..454472) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /label="ydbD gene" downshifts complement(453655) /Source="Nicolas_upshifts" /id="D210" /incds=0 /nref=62 /ntot=214 /MaxReadThrough="4.23505" /MaxDrop="6.82771" /score="-6.55917314" /energy="-13.1" /TU="U348" /idTUdmin="U348" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(454494..454512) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(454515) /Source="Nicolas_upshifts" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(454526..454532) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(454557..455609) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:1809844, 10708364, 11566984, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1809844, 10708364, 11566984, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane bound C4-dicarboxylate binding sensor protein" /protein_id="NP_388325.1" /db_xref="EnsemblGenomes-Gn:BSU04440" /db_xref="EnsemblGenomes-Tr:CAB12251" /db_xref="GOA:P96600" /db_xref="InterPro:IPR004682" /db_xref="InterPro:IPR018389" /db_xref="SubtiList:BG12072" /db_xref="UniProtKB/Swiss-Prot:P96600" /translation="MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQ IVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGD VQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLA YWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLL ENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILT EAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPI FGRELIRELLELRKDS*" /label="dctB CDS" gene complement(454557..455609) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /label="dctB gene" promotor_-35 454869..454876 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 454891..455678 /Source="Nicolas_S_feature" /locus_tag="new_496980_497767" /HighExp="LBGstat, Diami, T-0.40H, T0.0H, T0.30H, Heat, UNK1, GM-0.1, MG 90, Fru" /AntisenseName="dctB" /AntisenseCor="0.64205060306327899" /AntisenseRegPval="-31.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S149" promotor_-10 454891..454910 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 454892 /Source="Nicolas_upshifts" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(455622..455641) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(455627) /Source="Nicolas_upshifts" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(455655..455662) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 455679..457286 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388326.1" /db_xref="EnsemblGenomes-Gn:BSU04450" /db_xref="EnsemblGenomes-Tr:CAB12252" /db_xref="GOA:P96601" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12073" /db_xref="UniProtKB/Swiss-Prot:P96601" /translation="MNKKKLSIRWKITILSYILVIFSFLIGGIVLIGNIQHTEERELK KRLMNTARTVSEMTEVKEALARKKQTEAVRHAVEEIRMINEADYIVVMDMNHIRYTHP VSTSIGKKSEGADEEAAFAEHIYFSEAKGEIGTAVRAFYPVKDQDLNQIGVVLVGKTL PGIADILLHLKRDIAFIVVLTLGFGLAGSFLLARHIKKQMFQLEPHEIVRMYEERTAT FHSMNEGVIAIDNRLVITIFNEKAKQIFEVQGDLIGKVIWEVLKDSRLPEIVERNKAV YNEEIRVSGKVIMSSRIPIVMKKKVIGAVAIFQDRTEAAKMAEELTGVRNFVEALRVQ NHEHMNKLHTIAGLIQLGKSEKALQLAFQASTEQENVTEFLHRSIQNDAAAGLLLSKI RRGRELGIAVHIDENSSLQQFPEHVDQHDIVVLLGNLIENAFGSFETVQSEDKRIDIS IEQTDDILAILIEDNGCGIEPTHMPRLYDKGFTVNKTGGTGYGLYLVKQIIDKGSGTI EVDSHAGQGTSFSIVFPMKGEEAQHGS*" /label="dctS CDS" gene 455679..457286 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /label="dctS gene" CDS 457276..457956 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388327.1" /db_xref="EnsemblGenomes-Gn:BSU04460" /db_xref="EnsemblGenomes-Tr:CAB12253" /db_xref="GOA:P96602" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12074" /db_xref="UniProtKB/Swiss-Prot:P96602" /translation="MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGM KLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGA VDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNH FTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRP VNRYVLKG*" /label="dctR CDS" gene 457276..457956 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /label="dctR gene" S_feature 457957..458031 /Source="Nicolas_S_feature" /locus_tag="new_500046_500120" /HighExp="Sw, Diami, Mt0, G150, BI, Lbstat, M40t45, Lbtran, Mal, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S150" promotor_-35 457998..458005 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 458020..458037 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 458033 /Source="Nicolas_upshifts" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="upshifts" CDS 458077..459342 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480; Product type t: transporter" /codon_start=1 /transl_table=11 /product="C4-dicarboxylate transport protein" /protein_id="NP_388328.1" /db_xref="EnsemblGenomes-Gn:BSU04470" /db_xref="EnsemblGenomes-Tr:CAB12254" /db_xref="GOA:P96603" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR023954" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12075" /db_xref="UniProtKB/Swiss-Prot:P96603" /translation="MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVK MVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAG LDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVG LAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLAS LMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDK MERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLM LTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIAT IIVAKSENEFDEAKSIEAVEGMKKMKTAV*" /label="dctP CDS" gene 458077..459342 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /label="dctP gene" downshifts 459335 /Source="Nicolas_upshifts" /id="D211" /incds=0 /nref=175 /ntot=235 /MaxReadThrough="3.99042" /MaxDrop="7.04798" /score="45.0636559" /energy="-12.6" /TU="NA" /idTUdmin="U351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(459389) /Source="Nicolas_upshifts" /id="D212" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.588190000000001" /MaxDrop="3.06255" /score="19.3433396" /energy="-12.6" /TU="NA" /idTUdmin="U350" /TUdmin="-4818" /isTUend="FALSE" /label="downshifts" misc_feature 459426..459443 /Source="Nicolas_upshift_promotors" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 459428 /Source="Nicolas_upshifts" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 459490..460542 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388329.1" /db_xref="EnsemblGenomes-Gn:BSU04480" /db_xref="EnsemblGenomes-Tr:CAB12255" /db_xref="GOA:P96604" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG12076" /db_xref="UniProtKB/Swiss-Prot:P96604" /translation="MAALVKFFQHPGVRRFSIFVVLTGVLYLFKSMINLILLTFIFTF LMDRLELVVRQFVSQFFRVSQRVVITFLYMLLAVLLTVGGFVFYPVVAAQIQQLVKQI KHIAYHPDSIPFFDEITSVFGDINISSYVKEGFNVVYTYLADISTFGLQVVMALILSM FFLFEKKRLSEFMAKFKTSKLRVFYEEIAFFGSKFARTFGKVLEAQFIIALVNCILTF IALWIMHFPQLFGLSIMVFFLGLIPVAGVVISLIPLSIIAYSTGGGMYVLYIVLVIFA IHAIETYFLNPKLMSAKTELPIFFTFTVLIFSEHFFGIWGLIIGIPIFVFLLDILDVT NKEDRSKGPRENSDKK*" /label="ydbI CDS" gene 459490..460542 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /label="ydbI gene" S_feature 460543..460786 /Source="Nicolas_S_feature" /locus_tag="new_502632_502875" /HighExp="S8, S5, S6, LoTm, S7, S3, LBGstat, LBGexp, Paraq, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87223499999999998" /TUshortSig="Sig-" /TUshortPSig="0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S151" downshifts 460743 /Source="Nicolas_upshifts" /id="D213" /incds=0 /nref=6 /ntot=45 /MaxReadThrough="6.05001" /MaxDrop="3.52626" /score="17.6400305" /energy="-12.4" /TU="U352" /idTUdmin="U351" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" CDS 460819..461745 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding subunit)" /protein_id="NP_388330.1" /db_xref="EnsemblGenomes-Gn:BSU04490" /db_xref="EnsemblGenomes-Tr:CAB12256" /db_xref="GOA:P96605" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12077" /db_xref="UniProtKB/Swiss-Prot:P96605" /translation="MAEPILHIEGLDKKIGSKQILKQISMDVMEGEIIGLLGPNGSGK TTLIRIIVGLLKQNSGSVTISGFQHDTEFEKAMEAVGAIVENPEFYPYLTGWENLKHF ANMHKKIADERLDEVVERVGLTSAIHDKVKTYSLGMRQRLGIAQAILHRPKLLILDEP TNGLDPAGMKDFRDHIKELAEMEGTAVLFATHLLREVEDLCDRVIIIQKGEIKAEVSL QGTDQTTEKAIIEVQPQEKALNWLTGNQYQAESQDGTIVVEVAKENIPELNRSLVGQD LNVFSITPYTQSLEDEFIKATTAHQEEGEELV*" /label="ydbJ CDS" gene 460819..461745 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /label="ydbJ gene" CDS 461765..462505 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux ABC-transporter (permease subunit)" /protein_id="NP_388331.1" /db_xref="EnsemblGenomes-Gn:BSU04500" /db_xref="EnsemblGenomes-Tr:CAB12257" /db_xref="GOA:P96606" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12078" /db_xref="UniProtKB/Swiss-Prot:P96606" /translation="MKLFNRKVTLVSLILMAVFQFFMALIIKRIVISAGTDENFIGYL SYTPSLNILLQALTIVIAATIVSMEFDKKTIKFLLIRPVKRQKVFWSKLITVVMVSFY LYLAYYILALLFGLLFFGTSVTAESKTLLVNTLALIGSNWLEAVMMGLFGLLCSSLFR NSAVAVVVSFVVLYGASTLVQLMKLFENKWGSFLLFANTDFTQYRSGETALFSGMTPL FSIGILIIHAIFFIVVGWWCFCKRDVRV*" /label="ydbK CDS" gene 461765..462505 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /label="ydbK gene" misc_feature 462564..462583 /Source="Nicolas_upshift_promotors" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 462569 /Source="Nicolas_upshifts" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 462600..462935 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928292; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative glyco-prenyl flippase subunit" /protein_id="NP_388332.1" /db_xref="EnsemblGenomes-Gn:BSU04510" /db_xref="EnsemblGenomes-Tr:CAB12258" /db_xref="GOA:P96607" /db_xref="SubtiList:BG12079" /db_xref="UniProtKB/Swiss-Prot:P96607" /translation="MRNFITALPIVLLLGFSFVSFMFQFEHLVYFRLALGLFSLVGLY MIYKMKTGIRYFIIYLYASWIVLAAVTAFEEPIFSSFFFGGLVMTMGYLTYMLIYLGM KQDRDANPV*" /label="ydbL CDS" gene 462600..462935 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /label="ydbL gene" downshifts 462910 /Source="Nicolas_upshifts" /id="D214" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="5.33473" /MaxDrop="5.39081" /score="25.8152101" /energy="-18.4" /TU="U352,U353" /idTUdmin="U352" /TUdmin="-1177" /isTUend="FALSE" /label="downshifts" S_feature 462955..463024 /Source="Nicolas_S_feature" /locus_tag="new_505044_505113" /HighExp="ferm, nit, S2, S0, Gly, M0t45, M0t90, Lbstat, M/G, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.99, 0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S152" promotor_-35 462990..462997 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 463011..463030 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 463025 /Source="Nicolas_upshifts" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 463063..464208 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA dehydrogenase" /protein_id="NP_388333.1" /db_xref="EnsemblGenomes-Gn:BSU04520" /db_xref="EnsemblGenomes-Tr:CAB12259" /db_xref="GOA:P96608" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013107" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG12080" /db_xref="UniProtKB/Swiss-Prot:P96608" /translation="MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQK LRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNS WDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTT MSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVML DENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNV PAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDK AMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES*" /label="ydbM CDS" gene 463063..464208 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /label="ydbM gene" downshifts 464190 /Source="Nicolas_upshifts" /id="D215" /incds=0 /nref=13 /ntot=123 /MaxReadThrough="2.90782" /MaxDrop="4.20573" /score="9.48525091" /energy="-7" /TU="NA" /idTUdmin="U353" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(464233..464412) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /experiment="publication(s) with functional evidences, PMID:12354229, 16428414, 18697947, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16428414, 18697947, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="NP_388334.1" /db_xref="EnsemblGenomes-Gn:BSU04530" /db_xref="EnsemblGenomes-Tr:CAB12260" /db_xref="GOA:P96609" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG12081" /db_xref="UniProtKB/Swiss-Prot:P96609" /translation="MNTNMSGGRRSMPKRKVKTYQQLIQENKEAIMGNPKLMNVIYDR IDRKHQKNLQEQNNT*" /label="fbpB CDS" gene complement(464233..464412) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /label="fbpB gene" downshifts complement(464251) /Source="Nicolas_upshifts" /id="D216" /incds=0 /nref=158 /ntot=207 /MaxReadThrough="2.35872" /MaxDrop="6.38199" /score="26.3317207" /energy="-7" /TU="NA" /idTUdmin="U355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(464366..464530) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513944.1" /db_xref="EnsemblGenomes-Gn:BSU04536" /db_xref="EnsemblGenomes-Tr:CCQ48594" /db_xref="InterPro:IPR025072" /db_xref="UniProtKB/TrEMBL:L8ECQ9" /translation="MTPQSAEIRKKQLIHLLIQNGIYKKSKRHLYELSLTELESEYKH VRRAPEHAEA*" /label="fbpA CDS" gene complement(464366..464530) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /label="fbpA gene" S_feature complement(464413..464581) /Source="Nicolas_S_feature" /locus_tag="new_506502_506670_c" /HighExp="B60, nit, B36, Lbexp, GM 15, GM 10, dia0, S2, GM 25, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99141199999999996" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S153" promotor_-10 complement(464573..464592) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(464583) /Source="Nicolas_upshifts" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(464607..464614) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 464722..464727 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 464743..464761 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 464747 /Source="Nicolas_upshifts" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="upshifts" CDS 464777..465649 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cation efflux system" /protein_id="NP_388335.1" /db_xref="EnsemblGenomes-Gn:BSU04540" /db_xref="EnsemblGenomes-Tr:CAB12261" /db_xref="GOA:P96610" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12082" /db_xref="UniProtKB/Swiss-Prot:P96610" /translation="MERTENLKKGEKGALLNIFAYVILAVVKLVIGILYHSEALRADG LNNGTDIVASVAVLIGLRISQRPADSDHPYGHYRAETISSLVASFIMMAVGIEVLIGG GKAIAGGTTETPNLIAAWTALGSAVFMYGIYLYNKRLAASIKSSALMAAAKDSRSDAF VSAGAFIGVFSSQLKLPWVDPVTAFIIGIIICKTAWDIFKDASHSLTDGFHLKDLEPY KQTVGRIENVHRLKDVKARYLGSTVHIEMVITVDPKLTVEEGHGVADEVEDKIKHEHD VTHVHVHVEPDDIK*" /label="ydbO CDS" gene 464777..465649 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /label="ydbO gene" promotor_-35 465013..465022 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 465035..465050 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 465038 /Source="Nicolas_upshifts" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(465594..465663) /Source="Nicolas_S_feature" /locus_tag="new_507683_507752_c" /HighExp="LPhT, dia15, dia5, Diami, Etha, Lbtran, LBGtran, LBGstat, Mt0, M0t45" /AntisenseName="ydbO" /AntisenseCor="0.18463882527998399" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S154" downshifts complement(465637) /Source="Nicolas_upshifts" /id="D217" /incds=0 /nref=145 /ntot=242 /MaxReadThrough="3.07579" /MaxDrop="6.00116" /score="9.69023537" /energy="-12.3" /TU="U359" /idTUdmin="U359" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 465650..465999 /Source="Nicolas_S_feature" /locus_tag="new_507739_508088" /HighExp="Salt, Paraq, G135, ferm, Oxctl, T-0.40H, G150, Lbexp, T3.0H, T2.30H" /AntisenseName="ydbP" /AntisenseCor="-0.27800721625230801" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S155" CDS complement(465664..465984) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388336.1" /db_xref="EnsemblGenomes-Gn:BSU04550" /db_xref="EnsemblGenomes-Tr:CAB12262" /db_xref="GOA:P96611" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12083" /db_xref="UniProtKB/Swiss-Prot:P96611" /translation="MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILE EYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLS EHIS*" /label="ydbP CDS" gene complement(465664..465984) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /label="ydbP gene" promotor_-35 465980..465984 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 465993..466007 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 466001..466158 /Source="Nicolas_S_feature" /locus_tag="new_508090_508247" /HighExp="Lbexp, dia0, LBGexp, H2O2, Paraq, Oxctl, G180, Salt, M0t45, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigWXY" /TUshortPSig="0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S156" upshifts 466001 /Source="Nicolas_upshifts" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(466005..466024) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(466020) /Source="Nicolas_upshifts" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(466038..466045) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-35" CDS 466159..467223 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /EC_number="6.3.2.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8662022, 12682299, 22407814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine ligase A" /protein_id="NP_388337.1" /db_xref="EnsemblGenomes-Gn:BSU04560" /db_xref="EnsemblGenomes-Tr:CAB12263" /db_xref="GOA:P96612" /db_xref="InterPro:IPR000291" /db_xref="InterPro:IPR005905" /db_xref="InterPro:IPR011095" /db_xref="InterPro:IPR011127" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11932" /db_xref="UniProtKB/Swiss-Prot:P96612" /translation="MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRG ARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDG TIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKE SCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGR EIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMA IKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIE QLVELAKERHAEKQLIKHTF*" /label="ddlA CDS" gene 466159..467223 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /label="ddlA gene" downshifts 467211 /Source="Nicolas_upshifts" /id="D218" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="5.68418" /MaxDrop="2.53103" /score="3.92144467" /energy="-9.6" /TU="U357,U358" /idTUdmin="U356" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS 467295..468668 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /EC_number="6.3.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase" /protein_id="NP_388338.1" /db_xref="EnsemblGenomes-Gn:BSU04570" /db_xref="EnsemblGenomes-Tr:CAB12264" /db_xref="GOA:P96613" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005863" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG12084" /db_xref="UniProtKB/Swiss-Prot:P96613" /translation="MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFI PLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQ ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEI AVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKED GVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPI LGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNA SPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYG KLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKD LIESPLS*" /label="murF CDS" gene 467295..468668 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /label="murF gene" promotor_-35 468699..468705 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 468719..468730 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 468729 /Source="Nicolas_upshifts" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 468772..468791 /Source="Nicolas_upshift_promotors" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 468773..468947 /Source="Nicolas_S_feature" /locus_tag="new_510862_511036" /HighExp="Cold, ferm, nit, G135, S5, LBGexp, G150, S8, S7, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.76694499999999999" /TUshortSig="SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S157" upshifts 468773 /Source="Nicolas_upshifts" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 468915..468922 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 468937..468956 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 468949..469016 /Source="Nicolas_S_feature" /locus_tag="new_511038_511105" /HighExp="Cold, G150, T-3.40H, HPh, Salt, LPh, G180, G135, Oxctl, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S158" upshifts 468949 /Source="Nicolas_upshifts" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="upshifts" CDS 469068..470552 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16352840, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352840, 27965645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_388339.2" /db_xref="EnsemblGenomes-Gn:BSU04580" /db_xref="EnsemblGenomes-Tr:CAB12265" /db_xref="GOA:P96614" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030880" /db_xref="SubtiList:BG12085" /db_xref="UniProtKB/Swiss-Prot:P96614" /translation="MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVI GQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKV LPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNM GFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQ FYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLT QAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGR AGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTIS ENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRS SKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY*" /label="cshA CDS" gene 469068..470552 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /label="cshA gene" downshifts 470545 /Source="Nicolas_upshifts" /id="D219" /incds=0 /nref=309 /ntot=313 /MaxReadThrough="1.91428" /MaxDrop="8.13079" /score="26.104757" /energy="-13.1" /TU="NA" /idTUdmin="U358" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" S_feature 470665..470724 /Source="Nicolas_S_feature" /locus_tag="new_512754_512813" /HighExp="Etha, LBGexp, G180, Cold, Lbtran, dia0, G150, BMM, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S159" promotor_-35 470665..470674 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 470667 /Source="Nicolas_upshifts" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 470686..470701 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 470725..471204 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388340.1" /db_xref="EnsemblGenomes-Gn:BSU04590" /db_xref="EnsemblGenomes-Tr:CAB12266" /db_xref="GOA:P96615" /db_xref="InterPro:IPR005182" /db_xref="SubtiList:BG12086" /db_xref="UniProtKB/Swiss-Prot:P96615" /translation="MREQPKNQISPDGLKVWRLQEIIISAVCLLIVIAVAVLSYYFHW PYWISGVLGAVWLLGSIVTVFIIPKVRHKVWRYEVHEHEIDIQSGIFVVTRVIVPMVR VQHVDTSQGPLLKKYNLATVKISTAATVHSIPALEMEEADRLRDSISRLARVTDDDV* " /label="ydbS CDS" gene 470725..471204 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /label="ydbS gene" CDS 471194..472675 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388341.1" /db_xref="EnsemblGenomes-Gn:BSU04600" /db_xref="EnsemblGenomes-Tr:CAB12267" /db_xref="GOA:P96616" /db_xref="InterPro:IPR005182" /db_xref="InterPro:IPR014529" /db_xref="SubtiList:BG12087" /db_xref="UniProtKB/Swiss-Prot:P96616" /translation="MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTV RFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMN TSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELD EERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMD WLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGI IEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHK KKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSV ILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKK GRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG*" /label="ydbT CDS" gene 471194..472675 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /label="ydbT gene" downshifts 472645 /Source="Nicolas_upshifts" /id="D220" /incds=0 /nref=6 /ntot=162 /MaxReadThrough="4.90913" /MaxDrop="3.0931" /score="48.2239319" /energy="-17.1" /TU="U363" /idTUdmin="U364" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature 472690..473017 /Source="Nicolas_S_feature" /locus_tag="new_514779_515106" /HighExp="Salt, T0.30H, G135, T1.0H, T1.30H, G150, G180, Oxctl, T-0.40H, aero" /AntisenseName="ydcA" /AntisenseCor="-0.25636523135066602" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S160" downshifts complement(472699) /Source="Nicolas_upshifts" /id="D221" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="0.258529999999999" /MaxDrop="3.15455" /score="-3.74867023" /energy="-8.8" /TU="NA" /idTUdmin="U365" /TUdmin=220 /isTUend="FALSE" /label="downshifts" CDS complement(472927..473526) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /EC_number="3.4.21.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15616571, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhomboid protease" /protein_id="NP_388342.1" /db_xref="EnsemblGenomes-Gn:BSU04610" /db_xref="EnsemblGenomes-Tr:CAB12268" /db_xref="GOA:P96617" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG12088" /db_xref="UniProtKB/Swiss-Prot:P96617" /translation="MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRD TVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYA GSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLA FAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY*" /label="ydcA CDS" gene complement(472927..473526) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /label="ydcA gene" promotor_-35 472987..472992 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 473005..473024 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 473019..473620 /Source="Nicolas_S_feature" /locus_tag="new_515108_515709" /HighExp="Salt, G135, G150, T0.30H, G180, T1.0H, T1.30H, H2O2, Paraq, Oxctl" /AntisenseName="ydcA" /AntisenseCor="-0.11975373672841701" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S161" upshifts 473019 /Source="Nicolas_upshifts" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(473550..473569) /Source="Nicolas_upshift_promotors" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(473561) /Source="Nicolas_upshifts" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="upshifts" CDS 473621..473986 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /EC_number="2.7.8.7" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11489886, 11525165, 11867633, 12682299, 12926246, 15955059, 16597923; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="holo-acyl carrier protein synthase (phosphopantetheinyl transferase)" /protein_id="NP_388343.1" /db_xref="EnsemblGenomes-Gn:BSU04620" /db_xref="EnsemblGenomes-Tr:CAB12269" /db_xref="GOA:P96618" /db_xref="InterPro:IPR002582" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1F7L" /db_xref="PDB:1F7T" /db_xref="PDB:1F80" /db_xref="SubtiList:BG12089" /db_xref="UniProtKB/Swiss-Prot:P96618" /translation="MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEK RKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVS ITHTKEYAAAQVVIERLSS*" /label="acpS CDS" gene 473621..473986 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /label="acpS gene" promotor_-35 473989..473994 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-35" S_feature 474010..474151 /Source="Nicolas_S_feature" /locus_tag="new_516099_516240" /HighExp="S3, S4, BT, LoTm, S5, T5.0H, M9-stat, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S162" promotor_-10 474010..474028 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-10" upshifts 474010 /Source="Nicolas_upshifts" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="upshifts" CDS 474152..475168 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388344.2" /db_xref="EnsemblGenomes-Gn:BSU04630" /db_xref="EnsemblGenomes-Tr:CAB12270" /db_xref="GOA:P96619" /db_xref="InterPro:IPR029046" /db_xref="SubtiList:BG12090" /db_xref="UniProtKB/Swiss-Prot:P96619" /translation="MKKVRKSFVLLLTGLLAVLILSACGQKTQQDIVAGLDEKAKEYT SYKAKAKMTIETGSEPQVYNVEIWHKKPSLYRVYLENPKKDQNQVILRNENGVFVLTP SLNKSFRFQSDWPNNSSQVYLFESLVKDVQNDSDAVFTAKEKKYVFETKTNYQHNKML PTQEITFNKKDMSPSSVKVMDTDRKVMVKVEFSSFEFNKQFDKESFDEKKNMTLSQMD VATSAKPSDTFAVKTPLELPLGVKLLEEKDISTEDGKRIIMTYGGEKSFTLIQEKAQI AKASSSVTLNGEPVNLGYTIGALSDASLSWTYDGVDYLLSSKDLSKEEMVTVAKSMQG QSSK*" /label="ydcC CDS" gene 474152..475168 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /label="ydcC gene" downshifts 475153 /Source="Nicolas_upshifts" /id="D222" /incds=0 /nref=193 /ntot=256 /MaxReadThrough="3.39815" /MaxDrop="6.13946" /score="22.0391647" /energy="-9.5" /TU="U366" /idTUdmin="U363" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 475213..475220 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 475234..475253 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 475241 /Source="Nicolas_upshifts" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 475283..476452 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /EC_number="5.1.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2835089, 12682299, 15043879, 18399999, 25227915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine racemase" /protein_id="NP_388345.1" /db_xref="EnsemblGenomes-Gn:BSU04640" /db_xref="EnsemblGenomes-Tr:CAB12271" /db_xref="GOA:P10725" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10950" /db_xref="UniProtKB/Swiss-Prot:P10725" /translation="MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANA YGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYD VTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLK CKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNA VRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDT WIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIG RQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN*" /label="alrA CDS" gene 475283..476452 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /label="alrA gene" promotor_-35 476381..476386 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476401..476419 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476407 /Source="Nicolas_upshifts" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 476482..476485 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476501..476520 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476502 /Source="Nicolas_upshifts" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 476568..476849 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antitoxin EndoAI" /protein_id="NP_388346.1" /db_xref="EnsemblGenomes-Gn:BSU04650" /db_xref="EnsemblGenomes-Tr:CAB12272" /db_xref="GOA:P96621" /db_xref="InterPro:IPR002145" /db_xref="InterPro:IPR010985" /db_xref="InterPro:IPR013321" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12091" /db_xref="UniProtKB/Swiss-Prot:P96621" /translation="MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAY VSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG*" /label="ndoAI CDS" gene 476568..476849 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /label="ndoAI gene" CDS 476854..477204 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 21897862, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 21897862, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease toxin" /protein_id="NP_388347.1" /db_xref="EnsemblGenomes-Gn:BSU04660" /db_xref="EnsemblGenomes-Tr:CAB12273" /db_xref="GOA:P96622" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="PDB:1NE8" /db_xref="PDB:4MDX" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12092" /db_xref="UniProtKB/Swiss-Prot:P96622" /translation="MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIV AAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDK VDEALQISLALIDF*" /label="ndoA CDS" gene 476854..477204 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /label="ndoA gene" S_feature complement(476994..477470) /Source="Nicolas_S_feature" /locus_tag="new_519083_519559_c" /HighExp="Etha, Gly, Sw, S8, C30, S6, LBGstat, T0.30H, S7, Salt" /AntisenseName="ndoA" /AntisenseCor="-0.36117231948253697" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigK" /TUshortPSig="1, 1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S163" downshifts complement(477037) /Source="Nicolas_upshifts" /id="D223" /incds=1 /nref=6 /ntot=171 /MaxReadThrough="3.51096" /MaxDrop="3.79912" /score="-8.86444162" /energy="-10.2" /TU="U372" /idTUdmin="U371" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts 477184 /Source="Nicolas_upshifts" /id="D224" /incds=0 /nref=143 /ntot=254 /MaxReadThrough="5.57908" /MaxDrop="5.74865" /score="29.7721113" /energy="-8.9" /TU="U367,U368,U369" /idTUdmin="U366" /TUdmin=799 /isTUend="FALSE" /label="downshifts" promotor_-35 477238..477245 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 477259..477278 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 477267 /Source="Nicolas_upshifts" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 477319..478143 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress" /protein_id="NP_388348.1" /db_xref="EnsemblGenomes-Gn:BSU04670" /db_xref="EnsemblGenomes-Tr:CAB12274" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR014792" /db_xref="InterPro:IPR036513" /db_xref="PDB:2BNL" /db_xref="SubtiList:BG11090" /db_xref="UniProtKB/Swiss-Prot:P42409" /translation="MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYEN ISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDK RLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENI TVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAV RLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE*" /label="rsbRA CDS" gene 477319..478143 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /label="rsbRA gene" promotor_-10 complement(477453..477471) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(477470) /Source="Nicolas_upshifts" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(477472..478071) /Source="Nicolas_S_feature" /locus_tag="new_519561_520160_c" /HighExp="Etha, Sw, Gly, S6, S8, S7, B60, Salt, BT, M9-stat" /AntisenseName="rsbRA" /AntisenseCor="-0.53924606340364201" /AntisenseRegPval="-21" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S164" promotor_-35 complement(477485..477492) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(478060..478078) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(478071) /Source="Nicolas_upshifts" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(478073..478661) /Source="Nicolas_S_feature" /locus_tag="new_520162_520750_c" /HighExp="S6, S8, S7, BT, C30, S5, G135, C90, Gly, Fru" /AntisenseName="rsbS" /AntisenseCor="-0.57706416777859804" /AntisenseRegPval="-24.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S165" promotor_-35 complement(478092..478098) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 478148..478513 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 23320651, 28271471; Product type f : factor" /codon_start=1 /transl_table=11 /product="antagonist of RsbT" /protein_id="NP_388349.1" /db_xref="EnsemblGenomes-Gn:BSU04680" /db_xref="EnsemblGenomes-Tr:CAB12275" /db_xref="GOA:P42410" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11091" /db_xref="UniProtKB/Swiss-Prot:P42410" /translation="MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGA NGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEI ETALDLEQGLETLKRELGE*" /label="rsbS CDS" gene 478148..478513 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /label="rsbS gene" CDS 478517..478918 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine-threonine kinase; controlsthe activity of the anxiosome (stressosome)" /protein_id="NP_388350.1" /db_xref="EnsemblGenomes-Gn:BSU04690" /db_xref="EnsemblGenomes-Tr:CAB12276" /db_xref="GOA:P42411" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11092" /db_xref="UniProtKB/Swiss-Prot:P42411" /translation="MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAIS ELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGA GLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR*" /label="rsbT CDS" gene 478517..478918 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /label="rsbT gene" promotor_-10 complement(478659..478678) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(478676) /Source="Nicolas_upshifts" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(478692..478701) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 478930..479937 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 17303566, 21979936, 28461450" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 17303566, 21979936, 28461450; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine phosphatase; controls the activity of the anxiosome (stressosome)" /protein_id="NP_388351.1" /db_xref="EnsemblGenomes-Gn:BSU04700" /db_xref="EnsemblGenomes-Tr:CAB12277" /db_xref="GOA:P40399" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014787" /db_xref="InterPro:IPR017944" /db_xref="InterPro:IPR036457" /db_xref="PDB:1W53" /db_xref="PDB:2J6Y" /db_xref="PDB:2J6Z" /db_xref="PDB:2J70" /db_xref="SubtiList:BG11057" /db_xref="UniProtKB/Swiss-Prot:P40399" /translation="MDFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPP EEIISIHRKVLKELYPSLPEDVFHSLDFLIEVMIGYGMAYQEHQTLRGIQQEIKSEIE IAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAIADVIGKGI PAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQF TYASAGHEPGFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGV TECRTENGFLERPDLQKLIEEHMCSSAQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRK V*" /label="rsbU CDS" gene 478930..479937 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /label="rsbU gene" promotor_-35 479931..479937 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 479952..479970 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 479958 /Source="Nicolas_upshifts" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 479999..480328 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677; Product type f: factor" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of RsbW)" /protein_id="NP_388352.1" /db_xref="EnsemblGenomes-Gn:BSU04710" /db_xref="EnsemblGenomes-Tr:CAB12278" /db_xref="GOA:P17903" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG10733" /db_xref="UniProtKB/Swiss-Prot:P17903" /translation="MNINVDVKQNENDIQVNIAGEIDVYSAPVLREKLVPLAEQGADL RICLKDVSYMDSTGLGVFVGTFKMVKKQGGSLKLENLSERLIRLFDITGLKDIIDISA KSEGGVQ*" /label="rsbV CDS" gene 479999..480328 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /label="rsbV gene" CDS 480325..480807 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 21979936, 27977677; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein)" /protein_id="NP_388353.1" /db_xref="EnsemblGenomes-Gn:BSU04720" /db_xref="EnsemblGenomes-Tr:CAB12279" /db_xref="GOA:P17904" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010193" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10734" /db_xref="UniProtKB/Swiss-Prot:P17904" /translation="MKNNADYIEMKVPAQPEYVGIIRLTLSGVASRMGYTYDEIEDLK IAVSEACTNAVQHAYKEDKNGEVSIRFGVFEDRLEVIVADEGDSFDFDQKQQDLGPYT PSHTVDQLSEGGLGLYLMETLMDEVRVQNHSGVTVAMTKYLNGERVDHDTTIKNYETN *" /label="rsbW CDS" gene 480325..480807 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /label="rsbW gene" CDS 480773..481561 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-37 factor (sigma(B))" /protein_id="NP_388354.2" /db_xref="EnsemblGenomes-Gn:BSU04730" /db_xref="EnsemblGenomes-Tr:CAB12280" /db_xref="GOA:P06574" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014288" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10735" /db_xref="UniProtKB/Swiss-Prot:P06574" /translation="MTQPSKTTKLTKDEVDRLISDYQTKQDEQAQETLVRVYTNLVDM LAKKYSKGKSFHEDLRQVGMIGLLGAIKRYDPVVGKSFEAFAIPTIIGEIKRFLRDKT WSVHVPRRIKELGPRIKMAVDQLTTETQRSPKVEEIAEFLDVSEEEVLETMEMGKSYQ ALSVDHSIEADSDGSTVTILDIVGSQEDGYERVNQQLMLQSVLHVLSDREKQIIDLTY IQNKSQKETGDILGISQMHVSRLQRKAVKKLREALIEDPSMELM*" /label="sigB CDS" gene 480773..481561 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /label="sigB gene" CDS 481561..482160 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine phosphatase" /protein_id="NP_388355.1" /db_xref="EnsemblGenomes-Gn:BSU04740" /db_xref="EnsemblGenomes-Tr:CAB12281" /db_xref="GOA:P17906" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR036457" /db_xref="PDB:3W40" /db_xref="PDB:3W41" /db_xref="PDB:3W42" /db_xref="PDB:3W43" /db_xref="PDB:3W44" /db_xref="PDB:3W45" /db_xref="SubtiList:BG10736" /db_xref="UniProtKB/Swiss-Prot:P17906" /translation="MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVAD GLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQF TYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNV PDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS*" /label="rsbX CDS" gene 481561..482160 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /label="rsbX gene" downshifts 482146 /Source="Nicolas_upshifts" /id="D225" /incds=0 /nref=267 /ntot=278 /MaxReadThrough="2.46753" /MaxDrop="7.92167" /score="1.26147577" /energy="-6" /TU="NA" /idTUdmin="U369" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 482204..482210 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 482225..482244 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" Polymorphism join(482233,482235) /Source="geneious" /ID="SNP_BsDelta6_524323_524323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="A -> C" /Codon_Change /Coverage=183 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="BSU_04745_promoter_down_mutation" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 482237 /Source="Nicolas_upshifts" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 482271..482387 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513945.1" /translation="MWNYEYTAIADVDVGKPGTVIRKQKQWINGRRVLHQIL*" /label="hypothetical protein CDS" gene 482271..482387 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /label="gene" CDS 482403..482696 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388356.1" /db_xref="EnsemblGenomes-Gn:BSU04750" /db_xref="EnsemblGenomes-Tr:CAB12282" /db_xref="SubtiList:BG12093" /db_xref="UniProtKB/Swiss-Prot:P96623" /translation="MERKEHCFCKEKQFSYGLSMWRNIGRFLSWSTCPHSNVIMEFFH VLQKQKEDLCITYGIVLEGAEAKKWGEIIGTELSKDMPTAVSRLVHLYGGVIK*" /label="ydcF CDS" gene 482403..482696 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /label="ydcF gene" promotor_-35 482664..482672 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 482684..482703 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 482693..483133 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388357.1" /db_xref="EnsemblGenomes-Gn:BSU04760" /db_xref="EnsemblGenomes-Tr:CAB12283" /db_xref="InterPro:IPR002740" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR022996" /db_xref="SubtiList:BG12094" /db_xref="UniProtKB/Swiss-Prot:P96624" /translation="MNTNYWIGVVSEQHVLKGAAGGFAQLCHGKKAPLAKMKEGDWLI YYSPRDAYPDGKLLRSFTAIGKVKSGNIYPYQMAPNFIPYRLDIDYYPCHKIGFYDIK SKLEFVQETKHLGFLFRRGHFEISKKDFLTIAQAMGVNISGMAL*" /label="ydcG CDS" gene 482693..483133 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /label="ydcG gene" upshifts 482699 /Source="Nicolas_upshifts" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(482932..485987) /Source="Nicolas_S_feature" /locus_tag="new_525021_528076_c" /HighExp="S6, S8, S7, S5, B36, S4, B60, BT, Pyr, C30" /AntisenseName="ydcI" /AntisenseCor="-0.61304426345041496" /AntisenseRegPval="-28.4" /CDS_PredictionProba="0.40759499999999999" /TUshortSig="SigK" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S166" CDS 483117..483560 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12088660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388358.1" /db_xref="EnsemblGenomes-Gn:BSU04770" /db_xref="EnsemblGenomes-Tr:CAB12284" /db_xref="GOA:P96625" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12095" /db_xref="UniProtKB/Swiss-Prot:P96625" /translation="MEWHSKFSGPNTSPGFLLWQATQSWQRKVGKALAEFDLTHVQFV LLTSCKYMIAHGETVTQKKLASFSQTNIMMVSEVVRTLEKKGFIERSKNPQDKREVLL SLTEIGGEKVTAALPIVEKIDQAFFAAAMKKENFLSGLQELLKHE*" /label="ydcH CDS" gene 483117..483560 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /label="ydcH gene" downshifts 483535 /Source="Nicolas_upshifts" /id="D226" /incds=0 /nref=11 /ntot=147 /MaxReadThrough="2.17786" /MaxDrop="3.86856" /score="21.3746204" /energy="-6.8" /TU="NA" /idTUdmin="U376" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 483591..483592 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-35" promotor_-10 483608..483627 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-10" upshifts 483608 /Source="Nicolas_upshifts" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="upshifts" CDS 483654..485813 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755871, 12910271, 15383836, 16282592; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA helicase transcriptional accessory protein" /protein_id="NP_388359.2" /db_xref="EnsemblGenomes-Gn:BSU04780" /db_xref="EnsemblGenomes-Tr:CAB12285" /db_xref="GOA:O31489" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018974" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR023319" /db_xref="InterPro:IPR023323" /db_xref="InterPro:IPR032639" /db_xref="SubtiList:BG12096" /db_xref="UniProtKB/Swiss-Prot:O31489" /translation="METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKE QTGSMDEVQIQTISERWQYIQNLNQRKEEVIRLIAEQDKLTDNLKRKIEQSVKLQEVE DLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEEKEVFTREEA IEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPI AKVVPHRVLAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDS YKRLIQPAIEREIRKELSEKADEQAIHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGC KLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQ FIVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLA ELVKIDPKSVGVGQYQHDVSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLS KSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYEQCIGFLRVQEGTEPLDRTGIHPE SYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICEQLTRPE RDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLS NQFVKHPLDVVSVGDIVTVWVDGVDVQKGRVSLSMVK*" /label="tex CDS" gene 483654..485813 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /label="tex gene" misc_feature 485801..485820 /Source="Nicolas_upshift_promotors" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 485823..486039 /Source="Nicolas_S_feature" /locus_tag="new_527912_528128" /HighExp="Cold, Etha, LBGstat, dia5, LPhT, T4.0H, dia15, T3.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S167" upshifts 485823 /Source="Nicolas_upshifts" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="upshifts" CDS complement(485823..485936) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /function="16.3: Control" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:22463703, 26387458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22463703, 26387458; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor allowing degradation of SpoIVA by ClpXP" /protein_id="YP_009513946.1" /translation="MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS*" /label="cmpA CDS" gene complement(485823..485936) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /label="cmpA gene" promotor_-10 complement(485976..485995) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(485993) /Source="Nicolas_upshifts" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(486010..486018) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-35" CDS 486040..486492 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388360.1" /db_xref="EnsemblGenomes-Gn:BSU04790" /db_xref="EnsemblGenomes-Tr:CAB12286" /db_xref="GOA:P96628" /db_xref="InterPro:IPR006640" /db_xref="InterPro:IPR023524" /db_xref="InterPro:IPR035240" /db_xref="SubtiList:BG12098" /db_xref="UniProtKB/Swiss-Prot:P96628" /translation="MDNKELQKLTEDISETYFKKPFRHQALFNDRLKTTGGRYLLTSH NIELNRKYLIEHGREELIGIIKHELCHYHLHLEGKGYKHRDRDFRMLLQQVNAPRFCT PLKKKAENKKTYMYICTTCGQQYIKKRAMNPDRYRCGKCRGKIKRIFS*" /label="ydcK CDS" gene 486040..486492 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /label="ydcK gene" promotor_-35 486498..486504 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 486519..486538 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 486527..486614 /Source="Nicolas_S_feature" /locus_tag="new_528616_528703" /HighExp="C30, LBGstat, Cold, UNK1, GM 25, GM 120, GM 15, Heat, T-3.40H, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S168" upshifts 486527 /Source="Nicolas_upshifts" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(486559) /Source="Nicolas_upshifts" /id="D227" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="2.50342" /MaxDrop="3.97305" /score="8.78044068" /energy="-9.2" /TU="NA" /idTUdmin="U381" /TUdmin=704 /isTUend="FALSE" /label="downshifts" tRNA 486615..486689 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Asn tRNA" gene 486615..486689 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /label="trnS-Asn gene" tRNA 486694..486784 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Ser tRNA" gene 486694..486784 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /label="trnS-Ser gene" tRNA 486814..486885 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Glu tRNA" gene 486814..486885 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /label="trnS-Glu gene" tRNA 486897..486971 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Gln tRNA" gene 486897..486971 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /label="trnS-Gln gene" tRNA 486998..487073 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Lys tRNA" gene 486998..487073 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /label="trnS-Lys gene" tRNA 487085..487166 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu1 tRNA" gene 487085..487166 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /label="trnS-Leu1 gene" downshifts 487231 /Source="Nicolas_upshifts" /id="D228" /incds=0 /nref=3 /ntot=136 /MaxReadThrough="6.94232" /MaxDrop="3.5424" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA 487247..>487332 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu (GAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu2 tRNA" gene 487247..>487332 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /modified_by="User" /label="trnS-Leu2 gene" SCAR 487332..487333 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="Delta6_2" S_feature complement(<487333..487639) /Source="Nicolas_S_feature" /locus_tag="new_549923_550239_c" /HighExp="Diami, dia15, dia5, HPh, Etha, H2O2, Cold, LPh, C90, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /modified_by="User" /label="S175" downshifts 487352 /Source="Nicolas_upshifts" /id="D238" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="0.144629999999999" /MaxDrop="3.58923" /score="4.45688042" /energy="-12.2" /TU="NA" /idTUdmin="U389" /TUdmin=84 /isTUend="FALSE" /label="downshifts" downshifts complement(487384) /Source="Nicolas_upshifts" /id="D239" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.31925" /MaxDrop="3.67068" /score="-2.66780619" /energy="-18.7" /TU="NA" /idTUdmin="U391" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(487640..488659) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /EC_number="1.14.14.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_388385.1" /db_xref="EnsemblGenomes-Gn:BSU05040" /db_xref="EnsemblGenomes-Tr:CAB12311" /db_xref="GOA:P96651" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12121" /db_xref="UniProtKB/Swiss-Prot:P96651" /translation="MKKFDISVLSVAPLRQGETMKQGIDSAVSLAKAVDNMGYKRIWF AEHHNHDAYASAATVSIVQHILANTKDIRVGSGGIMLPNHSPLIVAEQFGTLETLYPN RVDLALGRAPGTDQKTADVIRRSNHNGVFFFEREVNDILRFVGDKSVQGEVRAYPGIG THVPVFVLGSSTDSAEIAAKLGLPYAFGAQFSPHSMEEALSIYRENFQPSSYLQEPYV IACINVIAAESIDEASFISASHLQVYIDIYTNNLSKLIPPTENFLESLSQFELEILHS RLGYTIMGDRETIRRELIDFQQMYHADELIVLSNIYELSKEIQSYEILKQVVDELFKK RMEQL*" /label="yddN CDS" gene complement(487640..488659) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /label="yddN gene" promotor_-10 complement(488335..488354) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(488348) /Source="Nicolas_upshifts" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(488369..488376) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 488448..488452 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488469..488488 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488473 /Source="Nicolas_upshifts" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="upshifts" S_feature 488474..488918 /Source="Nicolas_S_feature" /locus_tag="new_551074_551518" /HighExp="dia15, dia5, H2O2, G180, G135, Paraq, HPh, LBGexp, Lbexp, G150" /AntisenseName="yddN" /AntisenseCor="0.70327972625798696" /AntisenseRegPval="-40.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S176" CDS 488919..489329 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388386.1" /db_xref="EnsemblGenomes-Gn:BSU05050" /db_xref="EnsemblGenomes-Tr:CAB12312" /db_xref="GOA:P96652" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12122" /db_xref="UniProtKB/Swiss-Prot:P96652" /translation="MIDEIDKKILDELSKNSRLTMKKLGEKVHLTAPATASRVVKLID NGIIKGCSIEVNQVKLGFSIHAFLNIYIEKIHHQPYLAFIETQDNYVINNYKVSGDGC YLLECKFPSNEVLDQFLNDLNKHANYKVSIVIGK*" /label="lrpA CDS" gene 488919..489329 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /label="lrpA gene" S_feature 489330..489399 /Source="Nicolas_S_feature" /locus_tag="new_551930_551999" /HighExp="dia15, dia5, H2O2, HPh, G180, G135, LBGtran, Paraq, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S177" downshifts 489356 /Source="Nicolas_upshifts" /id="D240" /incds=0 /nref=45 /ntot=194 /MaxReadThrough="2.99689" /MaxDrop="3.6808" /score="-1.98969146" /energy="-15.7" /TU="U392" /idTUdmin="U392" /TUdmin="-350" /isTUend="FALSE" /label="downshifts" CDS complement(489452..489901) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388387.1" /db_xref="EnsemblGenomes-Gn:BSU05060" /db_xref="EnsemblGenomes-Tr:CAB12313" /db_xref="GOA:P96653" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12123" /db_xref="UniProtKB/Swiss-Prot:P96653" /translation="MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKME DNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDAC YLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE*" /label="lrpB CDS" gene complement(489452..489901) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /label="lrpB gene" CDS 490016..490558 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388388.1" /db_xref="EnsemblGenomes-Gn:BSU05070" /db_xref="EnsemblGenomes-Tr:CAB12314" /db_xref="GOA:P96654" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12124" /db_xref="UniProtKB/Swiss-Prot:P96654" /translation="MTTALLVIDIQNDYFPNGKMALTNPEKAAQNAAKLLSHFRNTGA PVFHVQHITEGNIAHFFHPNTEGVEIHESVRPLEKETVIVKHMPNSFFNTDLNGKLQE EGVKELVVCGMMSHMCIDATVRSAVEHGYVCQVVEDACATTTLQIEDKIVPAEHVHYA FMAALNGVYATVKTTEAFLK*" /label="yddQ CDS" gene 490016..490558 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /label="yddQ gene" promotor_-35 491031..491035 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 491052..491071 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 491061 /Source="Nicolas_upshifts" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="upshifts" CDS 491111..491875 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388389.1" /db_xref="EnsemblGenomes-Gn:BSU05080" /db_xref="EnsemblGenomes-Tr:CAB12315" /db_xref="GOA:P96655" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12125" /db_xref="UniProtKB/Swiss-Prot:P96655" /translation="MNITQIRNATIVVKYANKKFLIDPMLAEKGTYATFPETIRQDLF NPLVSLPTSIDNILDGVDAVIVTHLHLDHFDDVAKNVLPKNIKMFVQNEADAKEVKAS GFKNVEVLHQDTVFEGIQLVKTKGEHGRGEELLNLMGDVCGLVFKHPSEKVLYVAGDT VWYDAIEDEIHTHQPEIIVVNGGDNQRLDLGSLIMGKEDIYEVHKAAPHAKIISVHME AVNHWTLSREELKNFSKEKGFSSNILVPEDGESYTF*" /label="yddR CDS" gene 491111..491875 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /label="yddR gene" CDS 492069..493379 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388390.1" /db_xref="EnsemblGenomes-Gn:BSU05090" /db_xref="EnsemblGenomes-Tr:CAB12316" /db_xref="GOA:P96656" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12126" /db_xref="UniProtKB/Swiss-Prot:P96656" /translation="MVMTKKDTNISTQQPLWLQGYIDSPEKQNQLYKKTLKILIFSQI FGGAGLGAGITVGALLAQDMIGSENVAGIPTALFTFGSAVAALLIGASSQRFGRRAGL AGGFLIGGLGAIGVIIAALINSVALLFVSLLIYGAGMASNLQVRYAGTDLANEKQRAT AASMALVSTTLGAVVGPNLVNTMGEFADSIGVPNLAGPFIMSGAAFIIAGIILLIFLR PDPLFVSTAIANAEKKDDKVQIGGSLKNPAIDKKGIMVGAVIMILAQLIMTAIMTMTP VHMGHHGHGLSEVGLVIGLHIAAMYLPSPLTGLLVDKFGRTTMAIASGATLLAAGLVA AIAPADSLSLLILALVLLGVGWNFGLLTGTALIIDSTHPSLRAKTQGTFDVLLALSGA AGGALSGMVVAHSSYTILSISGAVLSLLLIPVVIWYFRRIQEKA*" /label="yddS CDS" gene 492069..493379 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /label="yddS gene" S_feature 493402..493961 /Source="Nicolas_S_feature" /locus_tag="new_556002_556561" /HighExp="S8, C30, Cold, BMM, C90, GM 25, MG 15, M/G, LPh, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S178" CDS 493962..494138 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved phage protein of unknown function" /protein_id="YP_003097682.1" /db_xref="EnsemblGenomes-Gn:BSU05099" /db_xref="EnsemblGenomes-Tr:CAX52553" /db_xref="GOA:Q9K3A9" /db_xref="UniProtKB/Swiss-Prot:Q9K3A9" /translation="MNNKKNIFDIVMYIIFGVLSLFLVAKTDYGTGVLVFVAILYLAV IAYKIKQVFSNSDS*" /label="ydzM CDS" gene 493962..494138 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /label="ydzM gene" CDS 494163..494849 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported phage protein" /protein_id="NP_388391.1" /db_xref="EnsemblGenomes-Gn:BSU05100" /db_xref="EnsemblGenomes-Tr:CAB12317" /db_xref="SubtiList:BG12127" /db_xref="UniProtKB/Swiss-Prot:P96657" /translation="MRKKRVITCVMAASLTLGSLLPAGYASAKEDSKTTPSYEELALH YKMKSEKISSNGKLVEIEYVSGNETHKVQMNGNNHTVKVDGIEQKGLNFEYDENVAKR TNYENNNLKSNEFTTQAAKPKKGYHYVGTLSGHTKAAKNALSVTMSLVGIVPGLGWGS KAATILFSYWAKEQIPDAYYKYDLYEKGAMTDSWYQYATVQFFEDKAHKKKMGKPWTS TPAKVDLPNS*" /label="yddT CDS" gene 494163..494849 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /label="yddT gene" promotor_-35 495191..495195 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-35" promotor_-10 495210..495229 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-10" upshifts 495218 /Source="Nicolas_upshifts" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="upshifts" Polymorphism join(495265,495267) /Source="geneious" /ID="SNP_BsDelta6_557866_557865" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)5 -> (T)6" /Codon_Change /Coverage=35 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value="3.2e-123" /Variant_Raw_Frequency=35 /comment="ydzN_translation_signal_variant" /modified_by="User" / /label="Polymorphism_Delta6" CDS 495274..495459 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097683.1" /db_xref="EnsemblGenomes-Gn:BSU05109" /db_xref="EnsemblGenomes-Tr:CAX52554" /db_xref="GOA:C0H3V7" /db_xref="UniProtKB/Swiss-Prot:C0H3V7" /translation="MRWSKWFNVFCIVALGSIYGYKLFTNQEVSTTRLIIASVIVLWN IVGLFSKESVKQAQQAN*" /label="ydzN CDS" gene 495274..495459 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /label="ydzN gene" downshifts 495458 /Source="Nicolas_upshifts" /id="D241" /incds=0 /nref=9 /ntot=125 /MaxReadThrough="3.39785" /MaxDrop="3.7067" /score="-6.31330934" /energy="-12.8" /TU="U394" /idTUdmin="U394" /TUdmin="-1068" /isTUend="FALSE" /label="downshifts" CDS 495809..496402 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /experiment="publication(s) with functional evidences, PMID:24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase III homolog, deglycase" /protein_id="NP_388392.1" /db_xref="EnsemblGenomes-Gn:BSU05110" /db_xref="EnsemblGenomes-Tr:CAB12318" /db_xref="GOA:P96658" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="PDB:3F5D" /db_xref="SubtiList:BG12128" /db_xref="UniProtKB/Swiss-Prot:P96658" /translation="MKKALFLILDQYADWEGVYLASALNQREDWSVHTVSLDPIVSSI GGFKTSVDYIIGLEPANFNLLVMIGGDSWSNDNKKLLHFVKTAFQKNIPIAAICGAVD FLAKNGLLNNHSHTGNFVYLWKDYKQYKPISSFVEKQAVRDKNLVTANGTAPIEFTNL ILEMIDFDTPENIEKMMYMNRYGFYHFCDKYGNPFVD*" /label="sufLC CDS" gene 495809..496402 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /label="sufLC gene" promotor_-35 496515..496522 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 496536..496555 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 496547..496664 /Source="Nicolas_S_feature" /locus_tag="new_559146_559263" /HighExp="B60, LoTm, T5.0H, T3.30H, M9-stat, BI, BC, C90, T3.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S179" upshifts 496547 /Source="Nicolas_upshifts" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(496582) /Source="Nicolas_upshifts" /id="D242" /incds=0 /nref=10 /ntot=93 /MaxReadThrough="1.86628" /MaxDrop="4.19111" /score="25.1917407" /energy="-12.9" /TU="NA" /idTUdmin="U396" /TUdmin=328 /isTUend="FALSE" /label="downshifts" CDS 496665..496865 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9379903, 9914312, 9920884, 10517332, 11591689, 12427936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379903, 9914312, 9920884, 10517332, 11591689, 12427936; Product type f : factor" /codon_start=1 /transl_table=11 /product="cold-shock protein" /protein_id="NP_388393.1" /db_xref="EnsemblGenomes-Gn:BSU05120" /db_xref="EnsemblGenomes-Tr:CAB12319" /db_xref="GOA:P39158" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11024" /db_xref="UniProtKB/Swiss-Prot:P39158" /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEG QKVSFDVEQGARGAQAANVQKA*" /label="cspC CDS" gene 496665..496865 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /label="cspC gene" S_feature complement(496763..497551) /Source="Nicolas_S_feature" /locus_tag="new_559362_560150_c" /HighExp="LoTm, B60, Cold, M9-stat, LPhT, B36, Sw, BC, S8, Salt" /AntisenseName="cspC" /AntisenseCor="0.39074308987975698" /AntisenseRegPval="-10.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S180" downshifts 496768 /Source="Nicolas_upshifts" /id="D243" /incds=1 /nref=19 /ntot=179 /MaxReadThrough="8.05368" /MaxDrop="3.4464" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 496869 /Source="Nicolas_upshifts" /id="D244" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="5.78621" /MaxDrop="5.83905" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=343 /isTUend="FALSE" /label="downshifts" misc_RNA complement(496933..497011) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /product="putative small conserved untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sncZ RNA" gene complement(496933..497011) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /label="sncZ gene" CDS complement(497552..498013) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26849219; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for repair and outgrowth of heat damaged spores" /protein_id="NP_388394.1" /db_xref="EnsemblGenomes-Gn:BSU05130" /db_xref="EnsemblGenomes-Tr:CAB12320" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG12129" /db_xref="UniProtKB/Swiss-Prot:P96659" /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMT VMIPTSKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQE GAEVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG*" /label="cdnL CDS" gene complement(497552..498013) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /label="cdnL gene" S_feature 498022..498567 /Source="Nicolas_S_feature" /locus_tag="new_560621_561166" /HighExp="Cold, G135, S8, G180, LoTm, S7, G150, HPh, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S181" upshifts complement(498065) /Source="Nicolas_upshifts" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(498072..498091) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(498107..498114) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 498534 /Source="Nicolas_upshifts" /id="D245" /incds=0 /nref=7 /ntot=141 /MaxReadThrough="0.289110000000001" /MaxDrop="4.3701" /score="26.1823933" /energy="-9.5" /TU="NA" /idTUdmin="U395" /TUdmin=864 /isTUend="FALSE" /label="downshifts" CDS complement(498581..498817) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388395.1" /db_xref="EnsemblGenomes-Gn:BSU05140" /db_xref="EnsemblGenomes-Tr:CAB12321" /db_xref="GOA:O31493" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12808" /db_xref="UniProtKB/Swiss-Prot:O31493" /translation="MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWI LLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS*" /label="ydzE CDS" gene complement(498581..498817) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /label="ydzE gene" CDS complement(498915..499790) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388396.1" /db_xref="EnsemblGenomes-Gn:BSU05150" /db_xref="EnsemblGenomes-Tr:CAB12322" /db_xref="GOA:P96660" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG12130" /db_xref="UniProtKB/Swiss-Prot:P96660" /translation="MKNFVIDQNLKELTEHRTVELPVACYKTTINQNINGYIPLHWHD EIQFVLILKGIALFQINEEKIEVHEGDGLFINSGYLHMAEEKEGSDCTYICLNVSPHF VLSQELYSSYVQPYMFSTNLPYLFLAGNQQWAKNILDAVKKINQLIQQKTSLYEIDIT MQLTLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYVEKITLEDIAKAGQLSR SECCRYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQ QAMNMTPLSYKKMNS*" /label="ydeC CDS" gene complement(498915..499790) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /label="ydeC gene" CDS 499903..500862 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388397.1" /db_xref="EnsemblGenomes-Gn:BSU05160" /db_xref="EnsemblGenomes-Tr:CAB12323" /db_xref="GOA:P96661" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12131" /db_xref="UniProtKB/Swiss-Prot:P96661" /translation="MNTSNRRMGLFYVITGATCWGIGGTVAKKLFQEYQIDVNWLVTT RLLTAGMLLLMLQLFRKDRSQVIEVWKHKASAGQLLIFGLLGMLAVQYTYMASIQHGN AAVATLLQYLSPVIVIIYTLLRKQTVLTKQDIITVVLALVGCFFLLTNGSMSQLSVPA AAVVWGVLSGFAAAFYTLYAVGLLNKFDSLVVVGWAMIIGGFALGFIHPPWQLDFQRL TAEAYAYILFVILFGTMIAFWFFIKSLESLSPKETSLLGSLEPLSAVVTTVVWLKAPF GSFQWIGAICIIGITLILALHKEPSMESEKSILKIRNHANRDI*" /label="ydeD CDS" gene 499903..500862 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /label="ydeD gene" upshifts complement(499924) /Source="Nicolas_upshifts" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(499928..499947) /Source="Nicolas_upshift_promotors" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(501015..501887) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388398.1" /db_xref="EnsemblGenomes-Gn:BSU05170" /db_xref="EnsemblGenomes-Tr:CAB12324" /db_xref="GOA:P96662" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12132" /db_xref="UniProtKB/Swiss-Prot:P96662" /translation="MDLLKSMNRALKYIEENLTNDIDFQEAAKLAFCSEYHFKRMFSF LAGISLSEYIRRRRLTLAAFELKDSNVKVIDIAIKYGYNSPDSFARAFQNLHGINPSK ARFNGHSLKAYPRMTFQLTIKGGNEMNYRIEEKEAFRIVGIKKRVPIIFKGINPEIAS MWESLDEKAINKLKELSNVAPSGLISASTNFSEGRTEENGELDHYIGAATTKRCPDNF SRLEVPASTWAVFESIGPFPDTLQEVWGRIYSEWFPSSNYEQIEGPEILWNEHKDVTS PSFKSEIWIPITKK*" /label="ydeE CDS" gene complement(501015..501887) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /label="ydeE gene" promotor_-10 complement(501980..501985) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(501987..501988) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(501992) /Source="Nicolas_upshifts" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 502061..502067 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 502075 /Source="Nicolas_upshifts" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 502081..502100 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 502114..503502 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388399.2" /db_xref="EnsemblGenomes-Gn:BSU05180" /db_xref="EnsemblGenomes-Tr:CAB12325" /db_xref="GOA:P96663" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12133" /db_xref="UniProtKB/Swiss-Prot:P96663" /translation="MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPG TKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTK PTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQR GGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPI KSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVI EDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALY NLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIF RWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQG LMILRRLLDDLT*" /label="ydeF CDS" gene 502114..503502 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /label="ydeF gene" downshifts 503478 /Source="Nicolas_upshifts" /id="D246" /incds=0 /nref=2 /ntot=61 /MaxReadThrough="0.91547" /MaxDrop="3.65963" /score="12.298375" /energy="-12.2" /TU="NA" /idTUdmin="U399" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS 503612..504904 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388400.1" /db_xref="EnsemblGenomes-Gn:BSU05190" /db_xref="EnsemblGenomes-Tr:CAB12326" /db_xref="GOA:P96664" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12134" /db_xref="UniProtKB/Swiss-Prot:P96664" /translation="MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQI FGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL SAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRAT AVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR PDPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPV HMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAA FAPGESMILLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA GGALSGMIVAGSSYLALSLIGGILSLLLIPVVVWSRGR*" /label="ydeG CDS" gene 503612..504904 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /label="ydeG gene" promotor_-35 504913..504919 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 504934..504953 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 504941 /Source="Nicolas_upshifts" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="upshifts" S_feature 504952..505062 /Source="Nicolas_S_feature" /locus_tag="new_567551_567661" /HighExp="LoTm, T4.0H, T3.30H, T2.30H, T3.0H, T2.0H, T1.30H, T5.0H, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S182" CDS 505063..505509 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388401.1" /db_xref="EnsemblGenomes-Gn:BSU05200" /db_xref="EnsemblGenomes-Tr:CAB12327" /db_xref="GOA:P96665" /db_xref="SubtiList:BG12135" /db_xref="UniProtKB/Swiss-Prot:P96665" /translation="MNHIKWLSDLKKAGLLALGKGVITLLKRFSLVIVTLMMSIVVVL AAAKESPGDHVISFDEPIILMISIGIVVFLLIPPLVMSFFGNLVVRIISGVYQCFIVF TFLGLIPIGFLIPNGFLTILVSIAGTLVSIASVAVTLCIGKNKKDI*" /label="ydeH CDS" gene 505063..505509 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /label="ydeH gene" downshifts 505538 /Source="Nicolas_upshifts" /id="D247" /incds=0 /nref=200 /ntot=251 /MaxReadThrough="2.56495" /MaxDrop="6.50538" /score="-1.7193297" /energy="-4.5" /TU="NA" /idTUdmin="U400" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 505589..505596 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 505611..505630 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 505612 /Source="Nicolas_upshifts" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="upshifts" CDS 505746..506339 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16390439" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388402.1" /db_xref="EnsemblGenomes-Gn:BSU05210" /db_xref="EnsemblGenomes-Tr:CAB12328" /db_xref="InterPro:IPR014922" /db_xref="InterPro:IPR016786" /db_xref="SubtiList:BG12136" /db_xref="UniProtKB/Swiss-Prot:P96666" /translation="MTNSRTNPKVDEFLSKAKKWKEEFEKLRTIILDCELTEDFKWMH PCYTYHNKNIVLIHGFKEYCALLFHKGVLLQDTDGILIQQTENVQAARQIRFTNVQEI NELENILKAYIHEAIEVEKAGLKVDVNKNIELNIPEELQNKFDEIPALKIAFEALTPG RQRAYTLYFSQAKQSKTRESRVEKYVQKILDGKGLKD*" /label="ydeI CDS" gene 505746..506339 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /label="ydeI gene" downshifts 506382 /Source="Nicolas_upshifts" /id="D248" /incds=0 /nref=2 /ntot=40 /MaxReadThrough="1.63432" /MaxDrop="2.96785" /score="2.93671425" /energy="-6.9" /TU="NA" /idTUdmin="U401" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(506458) /Source="Nicolas_upshifts" /id="D249" /incds=0 /nref=1 /ntot=64 /MaxReadThrough="2.19009" /MaxDrop="2.9369" /score="-1.28013562" /energy="-6.9" /TU="NA" /idTUdmin="U403" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 506471..506478 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 506492 /Source="Nicolas_upshifts" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 506493..506512 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(506691..507350) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388403.1" /db_xref="EnsemblGenomes-Gn:BSU05220" /db_xref="EnsemblGenomes-Tr:CAB12329" /db_xref="GOA:P96667" /db_xref="SubtiList:BG12137" /db_xref="UniProtKB/Swiss-Prot:P96667" /translation="MKKRRKICYCNTALLLMILLAGCTDSKDGEAQQPSNQASAVQTD EKHTEPEESTKIRKDEAEPITESEESATKAANDTSSAEEKSKEDNVLAAYSSEKIEYA RVWLQLGPNQEIDELNVRHIAAGEPINPNDDTSASYPENVTQLAGSRLVDGSVTYHGN GDGTIHVYNVPLRWDSADDIEKGVMREVTESIIKNRKTVYVDTGDDEKIKRLIDIMMI H*" /label="ydeJ CDS" gene complement(506691..507350) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /label="ydeJ gene" promotor_-10 complement(507399..507418) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(507406) /Source="Nicolas_upshifts" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(507430..507435) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(507772..508635) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388404.1" /db_xref="EnsemblGenomes-Gn:BSU05230" /db_xref="EnsemblGenomes-Tr:CAB12330" /db_xref="GOA:P96668" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12138" /db_xref="UniProtKB/Swiss-Prot:P96668" /translation="MNKTTNGWINGFIGVLIFSGSLPATRLAVSDFDPLFLTVCRAAI AGVLAGGLLLIFRQQHPAKRDLISLLVVAFGVVIGFPLLTALALQHVTSAHAIVFIGL LPLATAVFGVLRGGERPRPVFWIFSAAGSLLVAGFALIQGGGSSPLGDAYMLASIVVC GLGYAEGAKLSRRLGNWQVISWALVLSLPLMLPLSFFFTPDSWSAIGVPALLSLAYVS LFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLLLASVILHEKVGWALVAVNIAVI MCVAAARRFAK*" /label="ydeK CDS" gene complement(507772..508635) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /label="ydeK gene" promotor_-35 508678..508684 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 508699..508718 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(508700..508719) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 508714 /Source="Nicolas_upshifts" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(508724) /Source="Nicolas_upshifts" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(508734..508741) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 508790..510181 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /function="16.3: Control" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388405.1" /db_xref="EnsemblGenomes-Gn:BSU05240" /db_xref="EnsemblGenomes-Tr:CAB12331" /db_xref="GOA:P96669" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12139" /db_xref="UniProtKB/Swiss-Prot:P96669" /translation="MDITPFLNRTLDIPLYQQLYRYFKENMHRGRIQKGMKLPSKRLL ANQLSISQTTVERAYEQLAAEGYIVSKPRSGWFADYHDSDFAYDRMPSTTPIQQEAEE NKQWIDFHYGNVDSSYFPFSAWRKSMVNSLDQYGHELYRPGHVLGEFELRTLIAEYLY QSRGVHCGPEQVIIGAGNPILLQILCQVFEPNISIGYEDPGYPRARKIFEANRMNIVP IPVDDEGICIQKIKEQQPNLVYVTPSHQFTLGTIMTINRRIQLLKWAAENQSFIIEDD YDGEFRYTGQPVPSLQGLDQHNRVIYMGTFSKSLLPSLRISYMILPSPLLKKGHEITS LYKQTVSCHSQLTLAEFIKNGEWQKHINRMRKLYRKKRAIVLEAVQRELGEHVRIRGE NSGLRILLDVYLPFGEKELIEKAKKHGVKIYPVSLSYQHHPPTKTVSLGFAGVSESDI REGIKKLKAAWKI*" /label="ydeL CDS" gene 508790..510181 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /label="ydeL gene" promotor_-35 510309..510316 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-35" promotor_-10 510327..510346 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-10" upshifts 510341 /Source="Nicolas_upshifts" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="upshifts" CDS 510375..510800 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1556068, 26349822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase" /protein_id="NP_388406.1" /db_xref="EnsemblGenomes-Gn:BSU05250" /db_xref="EnsemblGenomes-Tr:CAB12332" /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12140" /db_xref="UniProtKB/Swiss-Prot:P96670" /translation="MKLDEFTIGQVFKTKSLKVSKDDIMRFAGEFDPQYMHVDEEKAS KGRFNGIIASGIQTLAISFKLWIEEGFYGDDIIAGTEMNHMTFIKPVYPDDELFTIVE VLDKQPKRNELGILTVLLSTYNQKEVKVFEGELSVLIKR*" /label="ydeM CDS" gene 510375..510800 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /label="ydeM gene" S_feature 510801..512055 /Source="Nicolas_S_feature" /locus_tag="new_573400_574654" /HighExp="G135, H2O2, G150, HiOs, G180, Cold, Paraq, UNK1, MG 15, LBGexp" /AntisenseName="ydeN" /AntisenseCor="0.40423774227585801" /AntisenseRegPval="-11.3" /CDS_PredictionProba="0.127641" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S183" CDS complement(510853..511425) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15159570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alpha/beta hydrolase" /protein_id="NP_388407.1" /db_xref="EnsemblGenomes-Gn:BSU05260" /db_xref="EnsemblGenomes-Tr:CAB12333" /db_xref="GOA:P96671" /db_xref="InterPro:IPR010662" /db_xref="InterPro:IPR029058" /db_xref="PDB:1UXO" /db_xref="SubtiList:BG12141" /db_xref="UniProtKB/Swiss-Prot:P96671" /translation="MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQ PRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKS LPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQIDAALYEVQ HGGHFLEDEGFTSLPIVYDVLTSYFSKETR*" /label="ydeN CDS" gene complement(510853..511425) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /label="ydeN gene" downshifts complement(510858) /Source="Nicolas_upshifts" /id="D250" /incds=0 /nref=16 /ntot=160 /MaxReadThrough="1.96868" /MaxDrop="3.80195" /score="2.50673989" /energy="-11.3" /TU="NA" /idTUdmin="U407" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(511426..511506) /Source="Nicolas_S_feature" /locus_tag="new_574025_574105_c" /HighExp="dia15, dia5, Diami, Etha, LPhT, Lbtran, Heat, H2O2, Sw, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S184" CDS complement(511507..511836) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388408.1" /db_xref="EnsemblGenomes-Gn:BSU05270" /db_xref="EnsemblGenomes-Tr:CAB12334" /db_xref="GOA:O31494" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12809" /db_xref="UniProtKB/Swiss-Prot:O31494" /translation="MNSLCRSKQAPFEYTLSLIGGKWKMRILYELGCEKTMRYGELKR AMPFITHKMLSAQLKELQTDGLIHRSEVSHTPLKVEYSLSDRGRSLYPLIDEMCKWGM AQGGPHM*" /label="ydzF CDS" gene complement(511507..511836) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /label="ydzF gene" misc_feature complement(511853..511872) /Source="Nicolas_upshift_promotors" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(511870) /Source="Nicolas_upshifts" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="upshifts" misc_feature 512044..512063 /Source="Nicolas_upshift_promotors" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 512057 /Source="Nicolas_upshifts" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="upshifts" CDS 512091..512963 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388409.1" /db_xref="EnsemblGenomes-Gn:BSU05280" /db_xref="EnsemblGenomes-Tr:CAB12335" /db_xref="GOA:P96672" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12142" /db_xref="UniProtKB/Swiss-Prot:P96672" /translation="MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDG GVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFF HHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLI LFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMV ETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDV AEVKGSNFRNLNHH*" /label="ydeO CDS" gene 512091..512963 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /label="ydeO gene" downshifts 512850 /Source="Nicolas_upshifts" /id="D251" /incds=1 /nref=7 /ntot=181 /MaxReadThrough="3.84278" /MaxDrop="2.68681" /score="15.0132064" /energy="-12.2" /TU="U408" /idTUdmin="U408" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 513048 /Source="Nicolas_upshifts" /id="D252" /incds=0 /nref=54 /ntot=208 /MaxReadThrough="1.19842" /MaxDrop="3.77294" /score="15.0132064" /energy="-12.2" /TU="NA" /idTUdmin="U408" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(513113..513499) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388410.1" /db_xref="EnsemblGenomes-Gn:BSU05290" /db_xref="EnsemblGenomes-Tr:CAB12336" /db_xref="GOA:P96673" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12143" /db_xref="UniProtKB/Swiss-Prot:P96673" /translation="MRNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKK RFNEFRKLYPKITQRMLTLQLRELERDGVIHREVYKQVPPKVEYSLTEFGRTLEPVIL HMKDWGEKYKDRIDKLEAARKAEDKI*" /label="ydeP CDS" gene complement(513113..513499) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /label="ydeP gene" downshifts complement(513125) /Source="Nicolas_upshifts" /id="D253" /incds=0 /nref=29 /ntot=191 /MaxReadThrough="0.85093" /MaxDrop="4.4837" /score="-9.3516261" /energy="-12.9" /TU="NA" /idTUdmin="U409" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(513500..513564) /Source="Nicolas_S_feature" /locus_tag="new_576099_576163_c" /HighExp="Diami, dia5, Salt, dia15, Etha, Heat, G180, HiOs, LBGexp, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S185" promotor_-35 513552..513559 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(513553..513572) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(513566) /Source="Nicolas_upshifts" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 513573..513592 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 513576 /Source="Nicolas_upshifts" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(513587..513594) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 513610..514203 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /EC_number="1.6.99.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase involved in regulating potassium efflux" /protein_id="NP_388411.1" /db_xref="EnsemblGenomes-Gn:BSU05300" /db_xref="EnsemblGenomes-Tr:CAB12337" /db_xref="GOA:P96674" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12144" /db_xref="UniProtKB/Swiss-Prot:P96674" /translation="MDHMKTLVLVVHPNIESSRINKKWKEAVLSEPDVTVHDLYEKYR DQPIDVEFEQQQLLAHDRIVFQFPLYWYSSPPLLKQWFDEVFTFGWAHGPGGNKLKGK EWVTAMSIGSPEHSYQAGGYNLFSISELTKPFQASAHLVGMTYLPSFAEYRANTISDQ EIAESANRYVKHITNIELNPKVRLQRYLKQLESVDLT*" /label="ydeQ CDS" gene 513610..514203 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /label="ydeQ gene" CDS complement(514347..515534) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388412.1" /db_xref="EnsemblGenomes-Gn:BSU05310" /db_xref="EnsemblGenomes-Tr:CAB12338" /db_xref="GOA:P96675" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12145" /db_xref="UniProtKB/Swiss-Prot:P96675" /translation="MANGNKQAGQRISPSLTLLLATACGIIVANLYYAQPLVGLISKA IGLSPSGAGLIVTLTQIGYVAGLLFLVPLGDIIENKKLIVVSLLLSAAALTLTAFVKH GTLFLAAAFFVGLGSIAAQVLVPFASYLASDAARGRVVGNVMSGLLLGIMLSRPISSL VADIWGWNAIFALSAVVSVILAIVLSKVLPARKPTANTNYTALLGSMWKLLRTTPVLR RRAIYHAFVFGAFSLFWTTVPLLLSGPDFHFSQKAIALYALVGIAGAVTAPIGGRLAD RGLTRLATGIALGVVVVSLLLPLMIQSSSPVGITVLVAAAILLDMGVSANLVLSQRAI FSLAPEIRSRLNGLFMAIFFLGGAIGSSIGGWAYASGGWSTALWIGIAFPVIALLYFI TEK*" /label="ydeR CDS" gene complement(514347..515534) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /label="ydeR gene" promotor_-35 515670..515674 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 515688 /Source="Nicolas_upshifts" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 515689..515708 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 515738..516334 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15944459; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388413.1" /db_xref="EnsemblGenomes-Gn:BSU05320" /db_xref="EnsemblGenomes-Tr:CAB12339" /db_xref="GOA:P96676" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011075" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12146" /db_xref="UniProtKB/Swiss-Prot:P96676" /translation="MQSKRGRPRDEGTHKAILSAAYDLLLEKGFDAVTVDKIAERAKV SKATIYKWWSNKAAVIMDSFLSTATDRLPVPDTGSSVQDIVTHATNLARFLTSREGTV IKELIGAGQLDEKLAEEYRTRFFQPRRLQAKGLLEKGIQKGELRENLDIEVSIDLIYG PIFYRLLITGDEVNDSYVRDLVMNAFKGVQATSATESM*" /label="ydeS CDS" gene 515738..516334 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /label="ydeS gene" CDS 516448..516633 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097684.1" /db_xref="EnsemblGenomes-Gn:BSU05329" /db_xref="EnsemblGenomes-Tr:CAX52555" /db_xref="UniProtKB/Swiss-Prot:C0H3V9" /translation="MSKKKSFNREYITSYYYIPFHRLEQGFYTSMEYRKVGVFKQQGK IDGHYVGVMAMEKILAM*" /label="ydzO CDS" gene 516448..516633 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /label="ydzO gene" downshifts 516612 /Source="Nicolas_upshifts" /id="D254" /incds=0 /nref=5 /ntot=123 /MaxReadThrough="1.06987" /MaxDrop="2.89833" /score="-5.04743481" /energy="-6.3" /TU="NA" /idTUdmin="U411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 516745..516748 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 516755..516941 /Source="Nicolas_S_feature" /locus_tag="new_579354_579540" /HighExp="LBGstat, G180, LBGexp, G135, Paraq, G150, Oxctl, dia0, Diami, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S186" upshifts 516755 /Source="Nicolas_upshifts" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 516763..516782 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 516942..517277 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15948947, 16430705" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16430705; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (metals sensing ArsR-SmtB repressors family)" /protein_id="NP_388414.1" /db_xref="EnsemblGenomes-Gn:BSU05330" /db_xref="EnsemblGenomes-Tr:CAB12340" /db_xref="GOA:P96677" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12147" /db_xref="UniProtKB/Swiss-Prot:P96677" /translation="MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMS QPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIK QKKTQACCQ*" /label="aseR CDS" gene 516942..517277 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /label="aseR gene" CDS 517290..518597 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12950922, 14970228, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite/antimonite/H+ antiporter" /protein_id="NP_388415.1" /db_xref="EnsemblGenomes-Gn:BSU05340" /db_xref="EnsemblGenomes-Tr:CAB12341" /db_xref="GOA:P96678" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12148" /db_xref="UniProtKB/Swiss-Prot:P96678" /translation="MTSMILAVFIFLLTLVLVIWQPKNLSIGWSACGGAVLALIAGVV NFHDVLTVTGIVWNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVS LLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIASGFIADTTSLPFVVS NLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRKSIPKRYDLTEVKKPV EAIKDQNMFRLSWYILGLLLIGYFASEFFSIPVSVVAGSIAIIFLIAAQKSPAVHTKK VVKEAPWAIVFFSIGMYVVVYGVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAIL SSIMNNLPTVMIDALAIAGTDTHGMMREALIYANVIGSDLGPKITPIGSLATLLWLHV LSHKGMKISWGTYFKTGIILTIPTLLITLVGLYIWLLIIHSCF*" /label="arsF CDS" gene 517290..518597 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /label="arsF gene" CDS 518629..518733 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of ydzS" /translation="CTGNSCRSQMAEGWGRKYLGAKWNVYSAGIEAQG*" /label="ydzSn CDS" gene 518629..518733 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /pseudo /label="ydzSn gene" CDS 518742..518855 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of ydzS" /translation="AVKAMKEAGIDISNQTSEKFDDPAKAHGTEEVFPKGP*" /label="ydzSc CDS" gene 518742..518855 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /pseudo /label="ydzSc gene" promotor_-35 519041..519049 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 519060..519078 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 519077 /Source="Nicolas_upshifts" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 519095..519880 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388416.1" /db_xref="EnsemblGenomes-Gn:BSU05350" /db_xref="EnsemblGenomes-Tr:CAB12342" /db_xref="GOA:P96679" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027365" /db_xref="SubtiList:BG12149" /db_xref="UniProtKB/Swiss-Prot:P96679" /translation="MSVLQELTKKKYSSLKTMFDDKYCPTFVYSILDQTIPGAVYADD QTFPKSFFIGTESGIYFIAGDQGNRDFHDFIAGYYEEQVKSSKRFTLFSSSDTWDSVL KPILKDDLNQMRRAAFSYQPKSFKKTLQLPKGLVLKRIDEDIISHSTAFNSAYYEEYW NSVSQFASKGFGFAVLHGNHVVSECTSIFLGHNRAEMDIYTLEEYRGLGLAYCVANRF IAFCMENGIVPSWDCDICNNSSIALAAKLGFKTVTEYTIYYSG*" /label="ydfB CDS" gene 519095..519880 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /label="ydfB gene" downshifts 519142 /Source="Nicolas_upshifts" /id="D255" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="2.67554" /MaxDrop="5.08398" /score="39.1565399" /energy="-19.2" /TU="NA" /idTUdmin="U413" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 519890 /Source="Nicolas_upshifts" /id="D256" /incds=0 /nref=2 /ntot=90 /MaxReadThrough="0.161840000000001" /MaxDrop="3.51451" /score="-0.169292431" /energy="-13.6" /TU="NA" /idTUdmin="U413" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS complement(519937..520857) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid exporter" /protein_id="NP_388417.1" /db_xref="EnsemblGenomes-Gn:BSU05360" /db_xref="EnsemblGenomes-Tr:CAB12343" /db_xref="GOA:P96680" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12150" /db_xref="UniProtKB/Swiss-Prot:P96680" /translation="MRKKTVQIMISHSLMIGLWASAFPGIRAGLEGYTPEHLALFRLL IGSMALLLFAVLTQMRLPDLKDIPAIFLLGFLGFAFYHILLNIGEKTVSAGVASLLVT TAPIFSAMLSRLFYKEHFGFTKWLGSMISLLGVLLIAFGAGDFTYSMSGILVILLAAF SESIYFVFQARYIKKYGFIPFVTFTIWGGTIPMLVFLPGLGEEMMNASISATLSIVYL GLLPTVIPYFALAYVTSFVGASEATLSLYVTPALALIISWLWIGEIPTLLSLLGGVVT VGGVCFTYLKVNKMNKIFITHFSAKRVKKL*" /label="ydfC CDS" gene complement(519937..520857) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /label="ydfC gene" CDS 520990..522438 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388418.1" /db_xref="EnsemblGenomes-Gn:BSU05370" /db_xref="EnsemblGenomes-Tr:CAB12344" /db_xref="GOA:P96681" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12151" /db_xref="UniProtKB/Swiss-Prot:P96681" /translation="MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLA KDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQ MPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKG YLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYS LHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRRE EILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIG WIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELA LSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKG NYIRLSYAYASLEDLQKGIYELGLMIKELASR*" /label="ydfD CDS" gene 520990..522438 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /label="ydfD gene" CDS complement(522556..523179) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavoprotein" /protein_id="NP_388419.1" /db_xref="EnsemblGenomes-Gn:BSU05380" /db_xref="EnsemblGenomes-Tr:CAB12345" /db_xref="GOA:P96682" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12152" /db_xref="UniProtKB/Swiss-Prot:P96682" /translation="MDIKKQDTRRFKEIKPKIMYYGTSTFLLTTLNEDGTTNISPMSS SWALGHYIILGVGLGGKAIDNLERHKECVINLPGPDLWENVERISSYSGKKSIPPLKK QIGFTYKKEKYEAAGLTPLQSKTVSPTRIKECPIQIEAEVKHIRLPEYESSFAIVETQ ALHFHAEESIILDENHINPSKWSPLIYNFRHYFGLGREVGKTFRSET*" /label="ydfE CDS" gene complement(522556..523179) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /label="ydfE gene" promotor_-10 complement(523203..523222) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 523211..523218 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(523222) /Source="Nicolas_upshifts" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 523233..523252 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 523235 /Source="Nicolas_upshifts" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(523237..523243) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 523269..523949 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388420.1" /db_xref="EnsemblGenomes-Gn:BSU05390" /db_xref="EnsemblGenomes-Tr:CAB12346" /db_xref="GOA:P96683" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12153" /db_xref="UniProtKB/Swiss-Prot:P96683" /translation="MNPNIAKISSLLSDPSRSSILLSLMDGRIHPAGELAYLANIKPQ TASFHLNKLLEAKLISVEKHGRHRYYRLADSDAANVIEQLLHIAPKAKVKSLKESKEK KDLHFARTCYDHLAGYVGVQMAHSLVEQGMLKKVDLNFEVTSEGALFFSKLGINEEQQ RNKRRAFARCCLDWSERQHHIAGALGNALLVRMLEEEWIVRMPKTRAIRITQSGKIAF EKHLNVKI*" /label="ydfF CDS" gene 523269..523949 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /label="ydfF gene" downshifts 523982 /Source="Nicolas_upshifts" /id="D257" /incds=0 /nref=113 /ntot=245 /MaxReadThrough="0.50202" /MaxDrop="4.24716" /score="-7.74889591" /energy="-4.5" /TU="U415" /idTUdmin="U415" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(524029..524472) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388421.1" /db_xref="EnsemblGenomes-Gn:BSU05400" /db_xref="EnsemblGenomes-Tr:CAB12347" /db_xref="GOA:P96684" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR004675" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG12154" /db_xref="UniProtKB/Swiss-Prot:P96684" /translation="MSQRVSYYEIAPEGMKIMMDMEKYTKQSSINRTTRELIKIRVSQ MNGCAFCIDMHTSDARKMGETEQRIYCLHAWNECDFYSPEEKAALELSEHITLIPSKR VPDELYHRVREHYDEEQYVDLVLIINQINSWNRISIAMGNRAASK*" /label="ydfG CDS" gene complement(524029..524472) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /label="ydfG gene" downshifts complement(524034) /Source="Nicolas_upshifts" /id="D258" /incds=0 /nref=10 /ntot=187 /MaxReadThrough="1.76648" /MaxDrop="3.73786" /score="0.225628164" /energy="-10.8" /TU="NA" /idTUdmin="U416" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(524495..524514) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(524519) /Source="Nicolas_upshifts" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(524528..524535) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(524558..524737) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097685.1" /db_xref="EnsemblGenomes-Gn:BSU05408" /db_xref="EnsemblGenomes-Tr:CAX52558" /db_xref="GOA:C0H3W0" /db_xref="UniProtKB/Swiss-Prot:C0H3W0" /translation="MNMYWFLGALLYFLIGTYIFIRVTRDSQSGSWILLALAAPLIIA GYPYFYSKKLLSKRR*" /label="ydzP CDS" gene complement(524558..524737) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /label="ydzP gene" CDS complement(524734..524877) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097686.1" /db_xref="EnsemblGenomes-Gn:BSU05409" /db_xref="EnsemblGenomes-Tr:CAX52559" /db_xref="UniProtKB/Swiss-Prot:C0H3W1" /translation="MKSIDLTILSLKRKGIRTEKVLKNQNPDRLSHMTDKNAQPKSKE KEE*" /label="ydzQ CDS" gene complement(524734..524877) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /label="ydzQ gene" promotor_-35 524828..524830 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 524846..524865 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 524862 /Source="Nicolas_upshifts" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 525145..526368 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YdfI]" /protein_id="NP_388422.1" /db_xref="EnsemblGenomes-Gn:BSU05410" /db_xref="EnsemblGenomes-Tr:CAB12348" /db_xref="GOA:P96685" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12155" /db_xref="UniProtKB/Swiss-Prot:P96685" /translation="MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQF VSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFI LVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMI VIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLV SLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKE RITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWIS IWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGT QIEITVPIQGEMQDE*" /label="ydfH CDS" gene 525145..526368 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /label="ydfH gene" CDS 526361..527002 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YdfH]" /protein_id="NP_388423.1" /db_xref="EnsemblGenomes-Gn:BSU05420" /db_xref="EnsemblGenomes-Tr:CAB12349" /db_xref="GOA:P96686" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12156" /db_xref="UniProtKB/Swiss-Prot:P96686" /translation="MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLAD ELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLL KDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAI AKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN*" /label="ydfI CDS" gene 526361..527002 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /label="ydfI gene" downshifts 526996 /Source="Nicolas_upshifts" /id="D259" /incds=0 /nref=5 /ntot=147 /MaxReadThrough="1.15378" /MaxDrop="2.65603" /score="8.33575703" /energy="-6.4" /TU="NA" /idTUdmin="U419" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(527029..527048) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(527050) /Source="Nicolas_upshifts" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(527062..527069) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 527110..527115 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 527118..529292 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative proton metabolite efflux transporter" /protein_id="NP_388424.1" /db_xref="EnsemblGenomes-Gn:BSU05430" /db_xref="EnsemblGenomes-Tr:CAB12350" /db_xref="GOA:P96687" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12157" /db_xref="UniProtKB/Swiss-Prot:P96687" /translation="MSKMLYTLGGWVARNRIKAICAWIVVLVAAIGLAVTLKPSFSED MSIPDTPSEKAMDVIQKEFPHGPDKGSIRVIFGAGDGEKLTGKPAKKAIEDTFKEISK DDSVDSIASPFVTGTIAKDGTVAYADIQYKSSADDIKDYSIKHLKDSLKMADDEGLQT ELSGDVPGAEMEIGGVSEIVGIILAFVVLAITFGSLLIAGLPILTALIGLGVSIGLVL IGTQVFDIASVSLSLAGMIGLAVGIDYALFIFTKHRQFLGEGIQKNESIARAVGTAGS AVVFAGLTVIVALCGLTVVNIPFMSAMGLTAGLSVLMAVLASITLVPAVLSIAGKRMI PKSNKKIEKQSTETNVWGRFVTKNPIMLSVCSILILIVISIPSMHLELGLPDAGMKAK DNPDRRAYDLLAEGFGEGFNGQLTIVADATNATENKAEAFADAVKEIKGLDHVASVTP AMPNKEGNFAIITVVPETGPNDVTTKDLVHDVRSLSDKNGVDLLVTGSTAVNIDISDR LNDAIPVFAVLIVGFAFVLLTIVFRSLLVPLVAVAGFMLTMTATLGICVFVLQDGNLI DFFKIPEKGPILAFLPILSIGILFGLAMDYQVFLVSRMREEYVKTNNPVQAIQAGLKH SGPVVTAAGLIMIFVFAGFIFAGEASIKANGLALSFGVLFDAFIVRMTLIPSVMKLMG NAAWYLPKWLDKIIPNVDIEGHQLTKEIQPEIDHEQKKQISV*" /label="ydfJ CDS" gene 527118..529292 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /label="ydfJ gene" upshifts 527128 /Source="Nicolas_upshifts" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 527130..527148 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(528194..528212) /Source="Nicolas_upshift_promotors" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(528194) /Source="Nicolas_upshifts" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(529296..529703) /Source="Nicolas_S_feature" /locus_tag="new_591895_592302_c" /HighExp="Paraq, H2O2, Oxctl, aero, LBGexp, dia15, GM 150, M/G, ferm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S187" promotor_-35 529313..529317 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 529327 /Source="Nicolas_upshifts" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 529330..529349 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(529341) /Source="Nicolas_upshifts" /id="D260" /incds=0 /nref=22 /ntot=134 /MaxReadThrough="-0.100210000000001" /MaxDrop="3.637" /score="4.29161871" /energy="-8.8" /TU="NA" /idTUdmin="U422" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(529704..530606) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7765103, 22248594, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7765103, 22248594, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase NP" /protein_id="NP_388425.1" /db_xref="EnsemblGenomes-Gn:BSU05440" /db_xref="EnsemblGenomes-Tr:CAB12351" /db_xref="GOA:P96688" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:2R11" /db_xref="SubtiList:BG11957" /db_xref="UniProtKB/Swiss-Prot:P96688" /translation="MSNHSSSIPELSDNGIRYYQTYNESLSLWPVRCKSFYISTRFGQ THVIASGPEDAPPLVLLHGALFSSTMWYPNIADWSSKYRTYAVDIIGDKNKSIPENVS GTRTDYANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAILSPAETFL PFHHDFYKYALGLTASNGVETFLNWMMNDQNVLHPIFVKQFKAGVMWQDGSRNPNPNA DGFPYVFTDEELRSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVL SMEQPTYVNERVMRFFNAETGISR*" /label="cesA CDS" gene complement(529704..530606) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /label="cesA gene" S_feature complement(530607..530702) /Source="Nicolas_S_feature" /locus_tag="new_593206_593301_c" /HighExp="nit, ferm, aero, LoTm, M/G, GM 150, Diami, Paraq, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S188" promotor_-10 complement(530682..530701) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(530702) /Source="Nicolas_upshifts" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(530715..530722) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(530808..531497) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10200972, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388426.1" /db_xref="EnsemblGenomes-Gn:BSU05450" /db_xref="EnsemblGenomes-Tr:CAB12352" /db_xref="GOA:P96689" /db_xref="InterPro:IPR007563" /db_xref="SubtiList:BG12158" /db_xref="UniProtKB/Swiss-Prot:P96689" /translation="MFGTIFNTVMIIAGSIIGGIFKKGIKDEYQDILMQAMGFAAVAL GINAITQHLPDSKYPILFIVSLAIGGLLGQIINLELRFNKLVNKFSKSNLAEGLSTAV LLFCIGSLSILGPVEAALHGDYTYLLTNGMLDGITSIVLASTFGFGIAAAALVLFSWQ GSIYLFAQVMESAINTDLINEITIVGGILILSSGLSILGIKKFKTLNLLPSLLIPPVV IFVIHAFGLRF*" /label="ydfK CDS" gene complement(530808..531497) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /label="ydfK gene" CDS complement(531587..532399) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of efflux transporter" /protein_id="NP_388427.1" /db_xref="EnsemblGenomes-Gn:BSU05460" /db_xref="EnsemblGenomes-Tr:CAB12353" /db_xref="GOA:P96690" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12159" /db_xref="UniProtKB/Swiss-Prot:P96690" /translation="MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYY STQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIE RKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVN EDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGS HPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK*" /label="ydfL CDS" gene complement(531587..532399) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /label="ydfL gene" promotor_-10 complement(532428..532447) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(532441) /Source="Nicolas_upshifts" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(532463..532470) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(532510..533403) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="primary Mn(II) efflux pump" /protein_id="NP_388428.2" /db_xref="EnsemblGenomes-Gn:BSU05470" /db_xref="EnsemblGenomes-Tr:CAB12354" /db_xref="GOA:C0SP78" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12160" /db_xref="UniProtKB/Swiss-Prot:C0SP78" /translation="MASEREQISRKVALIALIANLILMAGKVFFGLVGDSEAVFADGI HSAADVVASIAVLAVIGISNKPPDQDHPFGHGKAEVISEAIVGIILVIVSVYILIEAI LSFVKGPSVPQYSALFAALISYVAKEILYRYSIKQGKKWNSKAIIAIAYDHKGDIVAS LAAFIGVLLAIIGNSRGWSYLLYADAIASAIVAYLIFKISMELIRPSVDVLMEKSVDP ELIEEYKAVIFQCDQVKRIDRIRAREHGHYKLLDVRLSLDHDLTIKQGHDIAREIRNE IKRQFSDVEEVLIHVNPYFEE*" /label="mneP CDS" gene complement(532510..533403) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /label="mneP gene" downshifts complement(532530) /Source="Nicolas_upshifts" /id="D261" /incds=0 /nref=23 /ntot=121 /MaxReadThrough="1.07979" /MaxDrop="4.0938" /score="12.079524" /energy="-6.2" /TU="NA" /idTUdmin="U424" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(533404..533496) /Source="Nicolas_S_feature" /locus_tag="new_596003_596095_c" /HighExp="LPh, HPh, LPhT, UNK1, MG t5, MG 5, MG 15, BMM, GM 120, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S189" promotor_-10 complement(533477..533496) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(533494) /Source="Nicolas_upshifts" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(533512..533519) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 533685..533692 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 533707..533726 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 533713 /Source="Nicolas_upshifts" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 533879..534499 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388429.1" /db_xref="EnsemblGenomes-Gn:BSU05480" /db_xref="EnsemblGenomes-Tr:CAB12355" /db_xref="GOA:P96692" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="PDB:3BEM" /db_xref="SubtiList:BG12161" /db_xref="UniProtKB/Swiss-Prot:P96692" /translation="MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNL QHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGI LNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFD AEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM*" /label="ydfN CDS" gene 533879..534499 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /label="ydfN gene" promotor_-35 534223..534229 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 534234 /Source="Nicolas_upshifts" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 534243..534261 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 534515..535453 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /EC_number="1.13.11.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dioxygenase" /protein_id="NP_388430.1" /db_xref="EnsemblGenomes-Gn:BSU05490" /db_xref="EnsemblGenomes-Tr:CAB12356" /db_xref="GOA:P96693" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:3OAJ" /db_xref="SubtiList:BG12162" /db_xref="UniProtKB/Swiss-Prot:P96693" /translation="MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPG TYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFN VPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLS EQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHI AWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHD ETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD*" /label="ydfO CDS" gene 534515..535453 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /label="ydfO gene" promotor_-35 535441..535444 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 535459..535478 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 535466..535554 /Source="Nicolas_S_feature" /locus_tag="new_598065_598153" /HighExp="Etha, BT, S6, S7, S8, G/S, GM 10, Gly, GM 15, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB, SigA" /TUshortPSig="0.658, 0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S190" upshifts 535466 /Source="Nicolas_upshifts" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 535555..535944 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15306018, 15849754, 16850406, 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound oxidoreductase" /protein_id="NP_388431.1" /db_xref="EnsemblGenomes-Gn:BSU05500" /db_xref="EnsemblGenomes-Tr:CAB12357" /db_xref="GOA:P96694" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12163" /db_xref="UniProtKB/Swiss-Prot:P96694" /translation="MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESI GVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAG GFEYNLVLIAVSIGVALIGSGAYALHF*" /label="ydfP CDS" gene 535555..535944 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /label="ydfP gene" downshifts 535935 /Source="Nicolas_upshifts" /id="D262" /incds=0 /nref=3 /ntot=91 /MaxReadThrough="1.0642" /MaxDrop="3.85597" /score="-8.69038499" /energy="-9.3" /TU="NA" /idTUdmin="U427" /TUdmin=29 /isTUend="FALSE" /label="downshifts" misc_feature 536058..536077 /Source="Nicolas_upshift_promotors" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 536060..536129 /Source="Nicolas_S_feature" /locus_tag="new_598659_598728" /HighExp="Diami, dia5, H2O2, dia15, Etha, S8, Paraq, Salt, LPhT, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S191" upshifts 536060 /Source="Nicolas_upshifts" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 536130..536468 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388432.1" /db_xref="EnsemblGenomes-Gn:BSU05510" /db_xref="EnsemblGenomes-Tr:CAB12358" /db_xref="GOA:P96695" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12164" /db_xref="UniProtKB/Swiss-Prot:P96695" /translation="MKEMTGLHSLVSIENFIKQHKFSFIYISRPGCTVCHAVLPQLRI VLDQFPNIKLGHINADDVAEVAGRFSVFTVPVLLLFIDGTEFLREARFVHFEQLEQKL KRVYRLYEGE*" /label="ydfQ CDS" gene 536130..536468 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /label="ydfQ gene" downshifts 536456 /Source="Nicolas_upshifts" /id="D263" /incds=0 /nref=9 /ntot=28 /MaxReadThrough="1.76745" /MaxDrop="4.78737" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(536508..536744) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="NP_388433.1" /db_xref="EnsemblGenomes-Gn:BSU05520" /db_xref="EnsemblGenomes-Tr:CAB12359" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12810" /db_xref="UniProtKB/Swiss-Prot:O31496" /translation="MRSQINISNLTINGMTQNANTDIGQNLQNSHTANSKNYGVNFTL GDYSPSHSIIISASCDNDTSDQGQVDNPSSPSEE*" /label="ydzH CDS" gene complement(536508..536744) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /label="ydzH gene" downshifts complement(536532) /Source="Nicolas_upshifts" /id="D264" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.87679" /MaxDrop="2.5881" /score="9.38580075" /energy="-6" /TU="NA" /idTUdmin="U430" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 536556..536562 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 536577..536588 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 536588 /Source="Nicolas_upshifts" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(536745..536906) /Source="Nicolas_S_feature" /locus_tag="new_599344_599505_c" /HighExp="BT, B36, S8, S7, G135, S5, S6, G180, Pyr, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S192" S_feature complement(536910..537275) /Source="Nicolas_S_feature" /locus_tag="new_599509_599874_c" /HighExp="BT, B36, S8, S7, S6, G/S, S5, Pyr, B60, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigGF, SigK" /TUshortPSig="0.994, 0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S193" downshifts complement(536950) /Source="Nicolas_upshifts" /id="D265" /incds=0 /nref=26 /ntot=52 /MaxReadThrough="2.64253" /MaxDrop="4.6761" /score="8.29803249" /energy="-12.4" /TU="NA" /idTUdmin="U430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(537276..537506) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="YP_003097687.1" /db_xref="EnsemblGenomes-Gn:BSU05529" /db_xref="EnsemblGenomes-Tr:CAX52560" /db_xref="InterPro:IPR019618" /db_xref="UniProtKB/Swiss-Prot:C0H3W2" /translation="MMKFPVYIHSISGNSVFNNGFAVSISPFSVSKTTEGSGGSNTGL VFESNALSQTSSANQAQNVTYAIQELLSKLLA*" /label="ydzR CDS" gene complement(537276..537506) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /label="ydzR gene" downshifts 537490 /Source="Nicolas_upshifts" /id="D266" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.08051" /MaxDrop="3.36374" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(537527..537546) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(537544) /Source="Nicolas_upshifts" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(537546..537629) /Source="Nicolas_S_feature" /locus_tag="new_600145_600228_c" /HighExp="S8, S5, S7, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK" /TUshortPSig="0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S194" promotor_-35 complement(537560..537569) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(537630..538307) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_388434.1" /db_xref="EnsemblGenomes-Gn:BSU05530" /db_xref="EnsemblGenomes-Tr:CAB12360" /db_xref="GOA:P96696" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12165" /db_xref="UniProtKB/Swiss-Prot:P96696" /translation="MNRLPFGYIKLRLAGRKANPMTNLIHHWSGGSMNFTWESLVLIV AGVILLRISGRKSIAQMTSTQTVVMISIGTIIVQPIIEYSLFKTLIAAAIFTSTLIVM EWIQMKSNTIEKMLTGKAKIVIENGQLHIENLKKMRLTADQLEMQLRLHGVTAIQDVK IATLEANGQLGIELTDDAKPLTVRDLKKLIHPDFINKDGQAQSGNQNIFDEVGKKNKK NVPKKLH*" /label="ydfR CDS" gene complement(537630..538307) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /label="ydfR gene" promotor_-10 complement(538278..538289) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(538292) /Source="Nicolas_upshifts" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(538304..538310) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(538308..539141) /Source="Nicolas_S_feature" /locus_tag="new_600907_601740_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, nit, B60" /AntisenseName="ydfS" /AntisenseCor="0.65823831974361602" /AntisenseRegPval="-34.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S195" promotor_-35 538323..538328 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 538343..538354 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 538348 /Source="Nicolas_upshifts" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="upshifts" CDS 538420..539127 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388435.1" /db_xref="EnsemblGenomes-Gn:BSU05540" /db_xref="EnsemblGenomes-Tr:CAB12361" /db_xref="GOA:P96697" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12166" /db_xref="UniProtKB/Swiss-Prot:P96697" /translation="MIELEVVIRTVASFGLLLIAERILGKQTISQMTIFDFIAAITLG AIAAGLAYNTSIKPHNMAISFSIFVLTIFLISFLSIKNRKLRKFFAGDPTVLIQNGKI LESNMRKMRYTLDYLNQQLREKEIFNIEEVLFAILETNGQLTVLRKPQFRHVTKQDLM IAVNQEQRLPIELIMDGEIIENNLKQNRLTESWLLEELRKRDIKVKETVYAVLLGNGD IYVDQYKDHISVPMDKE*" /label="ydfS CDS" gene 538420..539127 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /label="ydfS gene" CDS complement(539142..539573) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11150673; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_388436.1" /db_xref="EnsemblGenomes-Gn:BSU05550" /db_xref="EnsemblGenomes-Tr:CAB12362" /db_xref="GOA:P96698" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG12167" /db_xref="UniProtKB/Swiss-Prot:P96698" /translation="MDFEKIRKWLEITNEYKQSDFWTNVLKYKAPEHFFDSEASTFVY DFYQDEEYNFIIVEMPGVYEEELTIRLLSKTQLLIKGTITPVFPAEMEVLRERYYGEI ERIIQLPEAAETHLLQIQLLNGLLHISYPRQVETVAFNKGL*" /label="cotP CDS" gene complement(539142..539573) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /label="cotP gene" CDS complement(539586..539828) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388437.1" /db_xref="EnsemblGenomes-Gn:BSU05560" /db_xref="EnsemblGenomes-Tr:CAB12363" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12168" /db_xref="UniProtKB/Swiss-Prot:P96699" /translation="MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSL GDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI*" /label="ydgA CDS" gene complement(539586..539828) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /label="ydgA gene" CDS complement(539842..540114) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388438.1" /db_xref="EnsemblGenomes-Gn:BSU05570" /db_xref="EnsemblGenomes-Tr:CAB12364" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12169" /db_xref="UniProtKB/Swiss-Prot:P96700" /translation="MPSTVINLYYLKINSISGNGSITIGEAAYNSPTNNQKSQGTNSS FGDTSPTESVMENFLNDPDVNDQTSIGNSDTSNVNAPPIAPPPILD*" /label="ydgB CDS" gene complement(539842..540114) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /label="ydgB gene" promotor_-10 complement(540136..540155) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(540140) /Source="Nicolas_upshifts" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(540169..540178) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 540333..540340 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 540356..540375 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 540364 /Source="Nicolas_upshifts" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="upshifts" CDS 540413..541000 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388439.1" /db_xref="EnsemblGenomes-Gn:BSU05580" /db_xref="EnsemblGenomes-Tr:CAB12365" /db_xref="GOA:P96701" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12170" /db_xref="UniProtKB/Swiss-Prot:P96701" /translation="MKSKGVESRKRLLKAAANEFSVRGFHDAKVSEIVKKAGFTQPSF YLYFQSKEAIFAELITDFHSRVRKLTESLLLENGLNTEDVSKRVLLAVETVFQFLDED KDLTKIGFFLNPEAKQMKKDLAMVLKENLEAEQRLGYFHSELDMETVAECLVGMIEHL TESFLLTGIKDPASLAAEVVNLLIYGMLPKGNDVR*" /label="ydgC CDS" gene 540413..541000 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /label="ydgC gene" CDS 540997..541341 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388440.1" /db_xref="EnsemblGenomes-Gn:BSU05590" /db_xref="EnsemblGenomes-Tr:CAB12366" /db_xref="GOA:P96702" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12171" /db_xref="UniProtKB/Swiss-Prot:P96702" /translation="MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTV TGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICL IVSIMIIMGSYT*" /label="ydgD CDS" gene 540997..541341 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /label="ydgD gene" S_feature 541342..541503 /Source="Nicolas_S_feature" /locus_tag="new_603941_604102" /HighExp="Salt, Diami, dia15, dia5, aero, H2O2, SMMPr, Etha, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S196" CDS 541504..541977 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388441.1" /db_xref="EnsemblGenomes-Gn:BSU05600" /db_xref="EnsemblGenomes-Tr:CAB12367" /db_xref="GOA:P96703" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12172" /db_xref="UniProtKB/Swiss-Prot:P96703" /translation="MAFTLEDMTEEEFEAFRGMSVQNFAKQNITSGTWTEKEAFEKSE QAYENMIPNGRDSSNHYFWNITNDQGERMGWLWLYADPLHPQKEAFIYSFGLYEAFRG KGLAQLALQTLDERARELGAERLALHVFAHNETAVYLYQKMGYAMTNIRMRKQLC*" /label="ydgE CDS" gene 541504..541977 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /label="ydgE gene" S_feature 541978..542670 /Source="Nicolas_S_feature" /locus_tag="new_604577_605269" /HighExp="Salt, H2O2, dia15, aero, T-2.40H, Diami, T-3.40H, T-1.40H, T-4.40H, T-0.40H" /AntisenseName="vmlR" /AntisenseCor="-7.1224465259194999E-2" /AntisenseRegPval="-0.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S197" downshifts complement(542120) /Source="Nicolas_upshifts" /id="D267" /incds=0 /nref=4 /ntot=88 /MaxReadThrough="0.39199" /MaxDrop="3.39645" /score="18.2783449" /energy="-8.8" /TU="NA" /idTUdmin="U436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(542137..543780) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16109936, 22226636, 24687494, 25891423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16109936, 22226636, 24687494, 25891423; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding cassette efflux transporter" /protein_id="NP_388442.1" /db_xref="EnsemblGenomes-Gn:BSU05610" /db_xref="EnsemblGenomes-Tr:CAB12368" /db_xref="GOA:P39115" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG10767" /db_xref="UniProtKB/Swiss-Prot:P39115" /translation="MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKS TLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFH QLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDR YFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMN GLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYT VRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLL NIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRH LGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLS QYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQE VLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD*" /label="vmlR CDS" gene complement(542137..543780) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /label="vmlR gene" S_feature complement(543815..544012) /Source="Nicolas_S_feature" /locus_tag="new_606414_606611_c" /HighExp="BC, Sw, B60, B36, LoTm, S7, HiOs, S4, BI, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S198" promotor_-35 543829..543831 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 543848..543866 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 543852 /Source="Nicolas_upshifts" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(543858) /Source="Nicolas_upshifts" /id="D268" /incds=0 /nref=210 /ntot=265 /MaxReadThrough="3.59768" /MaxDrop="6.27457" /score="29.5863709" /energy="-11.8" /TU="U436" /idTUdmin="U437" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 543978 /Source="Nicolas_upshifts" /id="D269" /incds=0 /nref=35 /ntot=150 /MaxReadThrough="1.71902" /MaxDrop="4.95368" /score="-7.23582918" /energy="-13.3" /TU="NA" /idTUdmin="U435" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(544004..544023) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(544016) /Source="Nicolas_upshifts" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(544036..544043) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(544099) /Source="Nicolas_upshifts" /id="D270" /incds=0 /nref=92 /ntot=203 /MaxReadThrough="2.22553" /MaxDrop="5.71399" /score="18.9878298" /energy="-13.3" /TU="NA" /idTUdmin="U437" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(544100..545476) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16109936, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388443.1" /db_xref="EnsemblGenomes-Gn:BSU05620" /db_xref="EnsemblGenomes-Tr:CAB12369" /db_xref="GOA:P96704" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12173" /db_xref="UniProtKB/Swiss-Prot:P96704" /translation="MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKS IHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWT YWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWF ALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVF AFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSES PFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLT QRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRK TRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIY KVRKAKHQ*" /label="ydgF CDS" gene complement(544100..545476) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /label="ydgF gene" misc_feature complement(545526..545545) /Source="Nicolas_upshift_promotors" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(545541) /Source="Nicolas_upshifts" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="upshifts" Polymorphism join(545615,545617) /Source="geneious" /ID="SNP_BsDelta6_608215_608214" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)5 -> (A)6" /Codon_Change /Coverage=41 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="8.2e-115" /Variant_Raw_Frequency=39 /comment="dinB_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" terminator 545616..545649 /created_by="User" /comment="dinB_terminator_improvement" /modified_by="User" /label="Delta6_dinB_Terminator" CDS complement(545648..546166) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1847907, 3110138, 12644484, 16267290, 22059487; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nuclease inhibitor" /protein_id="NP_388444.1" /db_xref="EnsemblGenomes-Gn:BSU05630" /db_xref="EnsemblGenomes-Tr:CAB12370" /db_xref="GOA:Q02886" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG10539" /db_xref="UniProtKB/Swiss-Prot:Q02886" /translation="MSDFAFKLYEYNVWANQQIFNRLKELPKEIYHQEIQSVFPSISH VLSHVYLSDLGWIEVFSGKTLSDALALAEQLKEQTEAKEIEEMEDLFLRLSERYILFL QQKEQLNKPLQIQNPSSGIMKTTVSELLPHVVNHGTYHRGNITAMLRQAGYASAPTDY GLYLFMTKTEKA*" /label="dinB CDS" gene complement(545648..546166) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /label="dinB gene" downshifts complement(545662) /Source="Nicolas_upshifts" /id="D271" /incds=0 /nref=35 /ntot=176 /MaxReadThrough="2.77148" /MaxDrop="6.32316" /score="16.2748201" /energy="-15" /TU="NA" /idTUdmin="U438" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(546192..546211) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(546211) /Source="Nicolas_upshifts" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(546227..546230) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 546248..546255 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 546270..546289 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 546288 /Source="Nicolas_upshifts" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="upshifts" CDS complement(546300..546701) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /locus_tag="BSU_05890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; C-terminal part of YhdU" /db_xref="SubtiList:BG12198" /modified_by="User" /translation="FFQSSNFRGKQKQYRDLLRGIFLEEIAHVELVQNTINALLDESG GEGVGSQGTDQAPLDEAVKHANPHHYIIGAQSSLPVDAGGNPWNGSWVYNHGNLITDL LDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_BSU_05890_3'_ext" CDS complement(546300..546428) /locus_tag="PG10_rand_002" /created_by="User" /transl_table=11 /pseudo /translation="MYNHGNLITDLLDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_rand_002" gene complement(546300..546701) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /old_locus_tag="BSU_05890" /pseudo /modified_by="User" /label="PG10_BSU_05890_3'_ext" gene complement(546300..546428) /locus_tag="PG10_rand_002" /created_by="User" /label="PG10_rand_002" CDS 546318..546410 /locus_tag="PG10_rand_001" /created_by="User" /transl_table=11 /pseudo /translation="MRLIRAHFINSCFLQHTCRLKKQVIQQVSN*" /label="PG10_rand_001" gene 546318..546410 /locus_tag="PG10_rand_001" /created_by="User" /modified_by="User" /label="PG10_rand_001" SCAR 546320..546321 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs22" CDS complement(546632..546826) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; N-terminal part of YhdU" /translation="MYYYKEELINIIKPDKPDPAAAKVLQEILGGHYGEMRTMMQFFS KALISEESRNSTAICFAAFF*" /label="ydhUn CDS" gene complement(546632..546826) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /pseudo /label="ydhUn gene" promotor_-10 complement(546859..546870) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(546867) /Source="Nicolas_upshifts" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(546884..546890) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 546945..546952 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 546966..546985 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box 546968..547068 /Source="Nicolas_upshift_promotors" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 546970 /Source="Nicolas_upshifts" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(547016) /Source="Nicolas_upshifts" /id="D286" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="2.24619" /MaxDrop="4.20389" /score="11.9939391" /energy="-9" /TU="NA" /idTUdmin="U456" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" upshifts 547028 /Source="Nicolas_upshifts" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 547036..547043 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 547057..547076 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 547072..547159 /Source="Nicolas_S_feature" /locus_tag="new_635022_635109" /HighExp="LBGstat, C30, Cold, Heat, Oxctl, T-1.10H, T-0.40H, T-1.40H, UNK1, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.96, 0.0919, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S204" upshifts 547072 /Source="Nicolas_upshifts" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" tRNA 547160..547236 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Arg tRNA" gene 547160..547236 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /label="trnE-Arg gene" tRNA 547250..547323 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(UCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Gly tRNA" gene 547250..547323 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /label="trnE-Gly gene" rRNA 547483..549037 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-16S rRNA" gene 547483..549037 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /label="rrnE-16S gene" rRNA 549205..552132 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-23S rRNA" gene 549205..552132 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /label="rrnE-23S gene" rRNA 552188..552304 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-5S rRNA" gene 552188..552304 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /label="rrnE-5S gene" tRNA 552318..552394 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Met tRNA" gene 552318..552394 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /label="trnE-Met gene" tRNA 552455..552531 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Asp tRNA" gene 552455..552531 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /label="trnE-Asp gene" downshifts 552528 /Source="Nicolas_upshifts" /id="D287" /incds=0 /nref=38 /ntot=211 /MaxReadThrough="6.00554" /MaxDrop="5.14761" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U460" /TUdmin="-3784" /isTUend="FALSE" /label="downshifts" promotor_-35 552632..552636 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 552652..552671 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 552656 /Source="Nicolas_upshifts" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="upshifts" CDS 552712..553689 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /EC_number="2.7.4.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-monophosphate kinase" /protein_id="NP_388471.1" /db_xref="EnsemblGenomes-Gn:BSU05900" /db_xref="EnsemblGenomes-Tr:CAB12409" /db_xref="GOA:O05514" /db_xref="InterPro:IPR006283" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10693" /db_xref="UniProtKB/Swiss-Prot:O05514" /translation="MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVD TMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAM YEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTG EIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSD GLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEE WEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK*" /label="thiL CDS" gene 552712..553689 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /label="thiL gene" CDS 553704..554180 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; ADP binding protein" /protein_id="NP_388472.1" /db_xref="EnsemblGenomes-Gn:BSU05910" /db_xref="EnsemblGenomes-Tr:CAB12410" /db_xref="GOA:O05515" /db_xref="InterPro:IPR003442" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12199" /db_xref="UniProtKB/Swiss-Prot:O05515" /translation="MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTF TKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGV CLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN*" /label="tsaE CDS" gene 553704..554180 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /label="tsaE gene" CDS 554161..554850 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; protease involved in TsaD function" /protein_id="NP_388473.1" /db_xref="EnsemblGenomes-Gn:BSU05920" /db_xref="EnsemblGenomes-Tr:CAB12411" /db_xref="GOA:O05516" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR022496" /db_xref="SubtiList:BG12200" /db_xref="UniProtKB/Swiss-Prot:O05516" /translation="MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVH SLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAAN GRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLF LGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLA EAEAKWIESQK*" /label="tsaB CDS" gene 554161..554850 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /label="tsaB gene" CDS 554860..555315 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /EC_number="2.3.1.267" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2828880; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein S18 alanine N-acetyltransferase" /protein_id="NP_388474.1" /db_xref="EnsemblGenomes-Gn:BSU05930" /db_xref="EnsemblGenomes-Tr:CAB12412" /db_xref="GOA:O05517" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR006464" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12201" /db_xref="UniProtKB/Swiss-Prot:O05517" /translation="MKTKAAVRNMRLEDIDHVYEIEASSFTSPWTKDSFYHELLENPY AHYLVIEKDGHLAGYCGIWIVMDDAQITNIAIKPEYRGQSLGETLFRSAVELCKEKDA RRLSLEVRVSNHPAQGLYKKFGMQPGGIRKNYYTDNGEDALIMWVTINE*" /label="rimI CDS" gene 554860..555315 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /label="rimI gene" CDS 555308..556348 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11073929, 12682299, 9743119, 20824107, 21625506, 21873492, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; glycation binding protein" /protein_id="NP_388475.1" /db_xref="EnsemblGenomes-Gn:BSU05940" /db_xref="EnsemblGenomes-Tr:CAB12413" /db_xref="GOA:O05518" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR017860" /db_xref="InterPro:IPR017861" /db_xref="InterPro:IPR022450" /db_xref="SubtiList:BG12202" /db_xref="UniProtKB/Swiss-Prot:O05518" /translation="MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKR FGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAK ALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIG ETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGL KSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVA ANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQP GLELTSYQSLTR*" /label="tsaD CDS" gene 555308..556348 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /label="tsaD gene" downshifts 556312 /Source="Nicolas_upshifts" /id="D288" /incds=0 /nref=39 /ntot=222 /MaxReadThrough="3.15518" /MaxDrop="4.65228" /score="3.97936019" /energy="-10.1" /TU="NA" /idTUdmin="U460" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(556578..558506) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11916677, 16109936, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388476.2" /db_xref="EnsemblGenomes-Gn:BSU05950" /db_xref="EnsemblGenomes-Tr:CAB12414" /db_xref="GOA:O05519" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12203" /db_xref="UniProtKB/Swiss-Prot:O05519" /translation="MMILQVNQLSKSFGADTILNNIKLEVRNRDRIAIVGRNGAGKST LLKIIAGQLSYEKGEIIKPKDITMGYLAQHTGLDSKLTIKEELLTVFDHLKAMEKEMR AMEEKMAAADPGELESIMKTYDRLQQEFKDKGGYQYEADVRSVLHGLGFSHFDDSTQV QSLSGGQKTRLALGKLLLTQPDLLILDEPTNHLDIDTLTWLEHYLQGYSGAILIVSHD RYFLDKVVNQVYEVSRAESKKYHGNYSAYLDQKAAQYEKDLKMYEKQQDEIAKLQDFV DRNLARASTTKRAQSRRKQLERMDVMSKPLGDEKSANFHFDITKQSGNEVLRVQDLTI SYENQPPLLTEVSFMLTRGESAALVGPNGIGKSTLLKTLIDTLKPDQGTISYGSNVSV GYYDQEQAELTSSKRVLDELWDEYPGLPEKEIRTCLGNFLFSGDDVLKPVHSLSGGEK ARLALAKLMLQKANFLILDEPTNHLDLDSKEVLENALIDYPGTLLFVSHDRYFINRIA TRVLELSSSHIEEYLGDYDYYTEKKTEQLELEKMNQQEETDKTPATVKSDSKRSYEEE KEWKKKERQRLRRIEEIETTVQTIEENISRNDELLCDPEVYQDHEKVQAIHADNEKLN QELESLLSEWEELSTEED*" /label="ydiF CDS" gene complement(556578..558506) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /label="ydiF gene" downshifts complement(556595) /Source="Nicolas_upshifts" /id="D289" /incds=0 /nref=170 /ntot=266 /MaxReadThrough="1.32926" /MaxDrop="5.81869" /score="16.702581" /energy="-12.6" /TU="NA" /idTUdmin="U463" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" misc_feature 558258..558277 /Source="Nicolas_upshift_promotors" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 558268 /Source="Nicolas_upshifts" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" S_feature 558270..558459 /Source="Nicolas_S_feature" /locus_tag="new_646220_646409" /HighExp="Diami, H2O2, dia5, Paraq, G135, G180, G150, Cold, dia15, BC" /AntisenseName="ydiF" /AntisenseCor="0.47406689574609401" /AntisenseRegPval="-15.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S205" promotor_-35 558424..558431 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 558445..558464 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 558461..558631 /Source="Nicolas_S_feature" /locus_tag="new_646411_646581" /HighExp="Diami, dia5, dia15, H2O2, Etha, G180, G150, Oxctl, Mt0, Paraq" /AntisenseName="ydiF" /AntisenseCor="0.63697451027099605" /AntisenseRegPval="-31.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S206" upshifts 558461 /Source="Nicolas_upshifts" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(558526..558545) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(558538) /Source="Nicolas_upshifts" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(558559..558566) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 558632..559144 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /EC_number="4.6.1.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10903949, 16632608, 18607082, 20606263, 25941396, 26575208; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdenum cofactor biosynthesis protein C" /protein_id="NP_388477.1" /db_xref="EnsemblGenomes-Gn:BSU05960" /db_xref="EnsemblGenomes-Tr:CAB12415" /db_xref="GOA:O05520" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="SubtiList:BG12204" /db_xref="UniProtKB/Swiss-Prot:O05520" /translation="MNGFSHFNEQGRAQMVDISEKSSTVRTAAAVSSVHMKNEVYEKI QSHDIGKGDVLAVAQVAGIMAAKQTSNIIPMCHPLSLSGVDISFDWKIKEAEVILHIK AQVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTFLLEKTGGKNGDFKRE LSEYNLEDQK*" /label="moaC CDS" gene 558632..559144 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /label="moaC gene" CDS 559141..559788 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription repressor of cydABCD and yjlC-ndh expression" /protein_id="NP_388478.1" /db_xref="EnsemblGenomes-Gn:BSU05970" /db_xref="EnsemblGenomes-Tr:CAB12416" /db_xref="GOA:O05521" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /db_xref="InterPro:IPR022876" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2VT2" /db_xref="PDB:2VT3" /db_xref="SubtiList:BG12205" /db_xref="UniProtKB/Swiss-Prot:O05521" /translation="MNKDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVK VDSATIRRDFSYFGALGKKGYGYNVDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLH YNFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQS ITDRLVALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEIE*" /label="rex CDS" gene 559141..559788 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /label="rex gene" promotor_no_box 559618..559718 /Source="Nicolas_upshift_promotors" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 559678 /Source="Nicolas_upshifts" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" CDS 559810..559983 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388479.1" /db_xref="EnsemblGenomes-Gn:BSU05980" /db_xref="EnsemblGenomes-Tr:CAB12417" /db_xref="GOA:O05522" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG12206" /db_xref="UniProtKB/Swiss-Prot:O05522" /translation="MPIGPGSLAVIAIVALIIFGPKKLPELGKAAGDTLREFKNATKG LTSDEEEKKKEDQ*" /label="tatAY CDS" gene 559810..559983 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /label="tatAY gene" CDS 559990..560754 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11007775, 15187182, 15849754, 16850406, 19049517, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007775, 15187182, 15849754, 16850406, 19049517, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388480.1" /db_xref="EnsemblGenomes-Gn:BSU05990" /db_xref="EnsemblGenomes-Tr:CAB12418" /db_xref="GOA:O05523" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG12207" /db_xref="UniProtKB/Swiss-Prot:O05523" /translation="MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPII VYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKE RKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQ LTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMV TVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ*" /label="tatCY CDS" gene 559990..560754 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /label="tatCY gene" downshifts 560734 /Source="Nicolas_upshifts" /id="D290" /incds=0 /nref=151 /ntot=251 /MaxReadThrough="4.01237" /MaxDrop="6.80817" /score="19.4098216" /energy="-12.7" /TU="NA" /idTUdmin="U461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560792..560983) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388481.1" /db_xref="EnsemblGenomes-Gn:BSU06000" /db_xref="EnsemblGenomes-Tr:CAB12419" /db_xref="GOA:O05524" /db_xref="InterPro:IPR025426" /db_xref="SubtiList:BG12208" /db_xref="UniProtKB/Swiss-Prot:O05524" /translation="MRNPVVWGMIYFAVGCIFTYLAASSPGSMWSFYSILLMVFAAYN ISISFKMFAFSFKIKKNQK*" /label="ydiK CDS" gene complement(560792..560983) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /label="ydiK gene" downshifts complement(560809) /Source="Nicolas_upshifts" /id="D291" /incds=0 /nref=211 /ntot=258 /MaxReadThrough="0.81338" /MaxDrop="6.43897" /score="25.5376889" /energy="-12.7" /TU="NA" /idTUdmin="U467" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(560980..561714) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /EC_number="3.4.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_388482.1" /db_xref="EnsemblGenomes-Gn:BSU06010" /db_xref="EnsemblGenomes-Tr:CAB12420" /db_xref="GOA:O05525" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG12209" /db_xref="UniProtKB/Swiss-Prot:O05525" /translation="MRKQYWFIILTYIIMQFSALIAIPLLFKFGYAGGQPTDENMLHA QGLWSVISFIACLVVVLLILRTVPKETLRNGQKDSIGLSILWAIAGFFIALFSQGIAG SIEYYVFGIGRESENTQAILDVIQAVPLMIIVSSIVGPILEEIIFRKIIFGALYEKTN FFFAGLISSVIFGIVHADLKHLLLYTAMGFTFAFLYARTKRIWVPIFAHLMMNTFVVI MQLEPVRNYLEQQSTQMQLIIGGLFL*" /label="ydiL CDS" gene complement(560980..561714) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /label="ydiL gene" promotor_-35 561372..561377 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 561392..561410 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 561394 /Source="Nicolas_upshifts" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 561713..561714 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-35" promotor_-10 561724..561738 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-10" upshifts 561746 /Source="Nicolas_upshifts" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="upshifts" promotor_-10 complement(561751..561770) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 561768..561876 /Source="Nicolas_S_feature" /locus_tag="new_649718_649826" /HighExp="S4, S5, H2O2, S3, S8, S6, Diami, Oxctl, G180, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.238" /TUlongSig="NA" /TUlongPSig="NA" /label="S207" upshifts complement(561771) /Source="Nicolas_upshifts" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(561784..561789) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 561850..561856 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 561870..561889 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 561878..561952 /Source="Nicolas_S_feature" /locus_tag="new_649828_649902" /HighExp="HiTm, Etha, dia15, Heat, C90, dia5, LoTm, Lbexp, H2O2, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S208" upshifts 561878 /Source="Nicolas_upshifts" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="upshifts" CDS 561953..562237 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11407116, 17031040, 9303302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11407116, 17031040, 9303302; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin small subunit" /protein_id="NP_388483.2" /db_xref="EnsemblGenomes-Gn:BSU06020" /db_xref="EnsemblGenomes-Tr:CAB12421" /db_xref="GOA:P28599" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="InterPro:IPR037124" /db_xref="SubtiList:BG10422" /db_xref="UniProtKB/Swiss-Prot:P28599" /translation="MLKPLGDRVVIELVESEEKTASGIVLPDSAKEKPQEGKIVAAGS GRVLESGERVALEVKEGDRIIFSKYAGTEVKYEGTEYLILRESDILAVIG*" /label="groES CDS" gene 561953..562237 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /label="groES gene" CDS 562284..563918 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9303302, 11407116, 17031040, 17420574, 22268681" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 11407116, 17031040, 17420574, 22268681; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin large subunit" /protein_id="NP_388484.1" /db_xref="EnsemblGenomes-Gn:BSU06030" /db_xref="EnsemblGenomes-Tr:CAB12422" /db_xref="GOA:P28598" /db_xref="InterPro:IPR001844" /db_xref="InterPro:IPR002423" /db_xref="InterPro:IPR018370" /db_xref="InterPro:IPR027409" /db_xref="InterPro:IPR027410" /db_xref="InterPro:IPR027413" /db_xref="SubtiList:BG10423" /db_xref="UniProtKB/Swiss-Prot:P28598" /translation="MAKEIKFSEEARRAMLRGVDALADAVKVTLGPKGRNVVLEKKFG SPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREG LKNVTAGANPVGVRKGMEQAVAVAIENLKEISKPIEGKESIAQVAAISAADEEVGSLI AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLDNPYI LITDKKITNIQEILPVLEQVVQQGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKA PGFGDRRKAMLEDIAVLTGGEVITEDLGLDLKSTQIAQLGRASKVVVTKENTTIVEGA GETDKISARVTQIRAQVEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKL RIEDALNSTRAAVEEGIVSGGGTALVNVYNKVAAVEAEGDAQTGINIVLRALEEPIRQ IAHNAGLEGSVIVERLKNEEIGVGFNAATGEWVNMIEKGIVDPTKVTRSALQNAASVA AMFLTTEAVVADKPEENGGGAGMPDMGGMGGMGGMM*" /label="groEL CDS" gene 562284..563918 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /label="groEL gene" S_feature 563919..564011 /Source="Nicolas_S_feature" /locus_tag="new_651869_651961" /HighExp="HiTm, Etha, dia15, Heat, Diami, dia5, C90, S1, S2, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S209" downshifts 563968 /Source="Nicolas_upshifts" /id="D292" /incds=0 /nref=228 /ntot=267 /MaxReadThrough="6.24882" /MaxDrop="5.77437" /score="-6.71161833" /energy="-16.3" /TU="U468" /idTUdmin="U466" /TUdmin=2112 /isTUend="FALSE" /label="downshifts" CDS complement(564006..564134) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); C-terminal part of YdzT; defective prophage 3" /translation="EAGVGIKEIQQQFGHSDINTTMDIYAHMTANMEKRSPNSLVN*" /label="ydzTc CDS" gene complement(564006..564134) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /pseudo /label="ydzTc gene" S_feature 564013..>565239 /Source="Nicolas_S_feature" /locus_tag="new_651963_653431" /HighExp="H2O2, Heat, dia15, Diami, S1, G135, G150, S2, G180, dia5" /AntisenseName="ydzT" /AntisenseCor="-2.9485116084752801E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="0.23100000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S210" CDS complement(564137..564295) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52563.1" /translation="MIYQDSSFIFEREDGHPQLRKVIETRLKRLLKKAGIKRMSPPTL LGIPIPPY*" /label="ydzT CDS" gene complement(564137..564295) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /pseudo /label="ydzT gene" CDS complement(564340..564468) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52564.1" /translation="MISQVTKTLYTPNNQIEKYQLLTPKTTGSVDIVRIDETMSIY*" /label="ydzT CDS" gene complement(564340..564468) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /pseudo /label="ydzT gene" CDS complement(564561..564770) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52565.1" /translation="MYEDRTLELNEQYSHNCLGGIHACGRMIFRKAKTQGIIKMNPTG DFQLPKKQQSIGKRGADTFSKARSI*" /label="ydzT CDS" gene complement(564561..564770) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /pseudo /label="ydzT gene" CDS complement(564763..565068) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); N-terminal part of YdzT; defective prophage 3" /db_xref="PSEUDO:CAX52566.1" /translation="MELSYLLGIDPLTKKRLEISKGRFKTKKEAPVAARHVELQNDNG TFIKESDMPFKTFAKGWLKIYNRSGVKISSVRASEKKMMHFIAVLGQYPISKTQKNV* " /label="ydzTn CDS" gene complement(564763..565068) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /pseudo /label="ydzTn gene" SCAR join(565239,565246) /created_by="AR/SM" /note="deletion occured in betwen marked nucleotides" /label="Delta6_1" N_region 565240..565245 /note="KpnI site (GGTACC)" /created_by="User" /label="Delta6_1" CDS complement(565344..567833) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11118449, 11390381, 12897001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11118449, 11390381, 12897001; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the glucitol operon" /protein_id="NP_388495.1" /db_xref="EnsemblGenomes-Gn:BSU06140" /db_xref="EnsemblGenomes-Tr:CAB12433" /db_xref="GOA:P39143" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR024123" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10178" /db_xref="UniProtKB/Swiss-Prot:P39143" /translation="MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDK IALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEAT TIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTE QPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCV DDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALAN YTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQL SGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMA LSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSK PPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSE QHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQW ASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSG WALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETI LNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYF NLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESN QKAIRLIDSWEPAIGIRGEVERLARATKENE*" /label="gutR CDS" gene complement(565344..567833) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /label="gutR gene" downshifts complement(565366) /Source="Nicolas_upshifts" /id="D298" /incds=0 /nref=56 /ntot=209 /MaxReadThrough="0.69715" /MaxDrop="4.256" /score="0.285109352" /energy="-13.9" /TU="NA" /idTUdmin="U474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(567847..567866) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(567873) /Source="Nicolas_upshifts" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(567880..567887) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 567936..567937 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 567952..568034 /Source="Nicolas_S_feature" /locus_tag="new_667383_667465" /HighExp="Lbstat, BI, M40t90, Mt0, M0t90, dia5, dia0, Lbexp, Lbtran, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.848" /TUlongSig="NA" /TUlongPSig="NA" /label="S220" upshifts 567952 /Source="Nicolas_upshifts" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 567953..567972 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 568035..569096 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /EC_number="1.1.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1460002, 8195086, 8195087, 12897001, 19784641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1460002, 8195086, 8195087, 12897001, 19784641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucitol (sorbitol) dehydrogenase" /protein_id="NP_388496.1" /db_xref="EnsemblGenomes-Gn:BSU06150" /db_xref="EnsemblGenomes-Tr:CAB12434" /db_xref="GOA:Q06004" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10177" /db_xref="UniProtKB/Swiss-Prot:Q06004" /translation="MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGI CGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGR CEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSV GIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGA THIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQ NEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAM ERALQFKNECLKVMVYPNR*" /label="gutB CDS" gene 568035..569096 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /label="gutB gene" CDS 569170..570561 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897001, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+-glucitol symporter; prophage region 3" /protein_id="NP_388497.1" /db_xref="EnsemblGenomes-Gn:BSU06160" /db_xref="EnsemblGenomes-Tr:CAB12435" /db_xref="GOA:O34368" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12795" /db_xref="UniProtKB/Swiss-Prot:O34368" /translation="MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFV NAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWV AFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEER TVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFF TVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNV NHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSS IPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVA LAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRY KHIISELEQRSAR*" /label="gutP CDS" gene 569170..570561 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /label="gutP gene" promotor_-35 570588..570595 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 570609..570628 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 570614 /Source="Nicolas_upshifts" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="upshifts" CDS 570656..571618 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26483775, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar kinase (ribokinase family); prophage region 3" /protein_id="NP_388498.1" /db_xref="EnsemblGenomes-Gn:BSU06170" /db_xref="EnsemblGenomes-Tr:CAB12436" /db_xref="GOA:O34768" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12796" /db_xref="UniProtKB/Swiss-Prot:O34768" /translation="MRSHSVVCIGELLIDFFCTDVDVDLMEGRQFLKSAGGAPANVSA AIAKLGGDAAFSGKVGKDPFGYFLKRTLDAVHVDTSMLVMDEKAPTTLAFVSLKQNGE RDFVFNRGADALFTLEDIDQEKLNEAKILHFGSATALLSDPFCSAYLRLMSIAKDNGQ FISFDPNYREDLWRGRVSEFVSVAKKAIAVSDFVKVSDEELEIISGVKDHEKGVAILH EIGANIVAVTLGKSGTLLSNGKDREIIPSIPVTSIDSTGAGDAFVGAALYQLANTDQI QSVDADFVKLREIVAFANKVGALVCTKIGAIDALPSLDEIGVSL*" /label="ydjE CDS" gene 570656..571618 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /label="ydjE gene" downshifts 571603 /Source="Nicolas_upshifts" /id="D299" /incds=0 /nref=86 /ntot=213 /MaxReadThrough="2.99546" /MaxDrop="4.52045" /score="16.4550614" /energy="-14" /TU="NA" /idTUdmin="U475" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 571743..571752 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 571759 /Source="Nicolas_upshifts" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 571765..571780 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 571814..572497 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11454200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11454200; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage shock protein A homolog regulator; prophage region 3" /protein_id="NP_388499.1" /db_xref="EnsemblGenomes-Gn:BSU06180" /db_xref="EnsemblGenomes-Tr:CAB12437" /db_xref="GOA:P54617" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG12797" /db_xref="UniProtKB/Swiss-Prot:P54617" /translation="MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVK AETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLS ELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVS STSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAA LKAKMMLDK*" /label="pspA CDS" gene 571814..572497 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /label="pspA gene" S_feature 572498..572562 /Source="Nicolas_S_feature" /locus_tag="new_671929_671993" /HighExp="Salt, S0, aero, T-0.40H, T-1.40H, SMMPr, T-1.10H, T0.0H, Cold, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S221" CDS 572563..573588 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /function="16.5: Explore" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage replication protein; prophage region 3" /protein_id="NP_388500.1" /db_xref="EnsemblGenomes-Gn:BSU06190" /db_xref="EnsemblGenomes-Tr:CAB12438" /db_xref="GOA:O34434" /db_xref="InterPro:IPR013137" /db_xref="SubtiList:BG12798" /db_xref="UniProtKB/Swiss-Prot:O34434" /translation="MIISYKCPNCGSDMAFDSETGSLSCSSCGRQDNIESLPKENIAA RFSDDEAKEYQCKNCGAVLITEAETTATTCSFCGGAAILADRLSGHLAPAKVIPFTIS KQEAEQAFRKWCKKGLLTPRGFMSADRIKSITGMYIPFWMFDLNSEVQVRANCTRVHQ YEEGDYICTETEHFEAFRDINLDYLKIPVDASEKMKDELMDKLEPYSYEELKDFQTAY LAGYIAEKYNYTDEELFPRAKEKISSYIDSYIHSTFSGYTSVNVRDKHIHTKNVNSFY VLLPVWMVSYDYERAEHIFAMNGQTGKVVGKPPISRGKVAAWFSGIAGGTFLALKLVS LMMGGGF*" /label="ydjG CDS" gene 572563..573588 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /label="ydjG gene" CDS 573588..574352 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388501.1" /db_xref="EnsemblGenomes-Gn:BSU06200" /db_xref="EnsemblGenomes-Tr:CAB12439" /db_xref="GOA:O35004" /db_xref="InterPro:IPR007621" /db_xref="SubtiList:BG12799" /db_xref="UniProtKB/Swiss-Prot:O35004" /translation="MRGFFGKAIFVVLAVFIMMPLLGIEAVRASELQQHVYDRAHLLS KAEIGKLESLSAKLGAKRDTDFIIITTKSTNGEDIADYTGDFYDRYGKGSTAILTIDM TNREVFIAGFKKAEQYLDNSRLNSIRNTISSDLSNENYFEAFETYIQLSYKDMGIKPG VNPDNIFFTWWFQLIAAIAVGGIAVSIMLYHAGGKVTVNGSTYMDQRTSDVIDQYDTY IRTTVTRERKPSDKDSGSDGGVTKGGTSYSGSRGSF*" /label="ydjH CDS" gene 573588..574352 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /label="ydjH gene" CDS 574383..575354 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388502.1" /db_xref="EnsemblGenomes-Gn:BSU06210" /db_xref="EnsemblGenomes-Tr:CAB12440" /db_xref="InterPro:IPR033880" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG12800" /db_xref="UniProtKB/Swiss-Prot:O34789" /translation="MSFFRNQLANVVEWEEFRDDMIFYKWNNREIKKGSRLIIRPGQD AVFLNNGRVEGVFQDDGDYDIESEIIPFLSTLKGFKFGFNSGMRAEVLFVNTKEFTVR WGTKQAINIPAAGMPGGMPIRANGTFNFKVQDYISLIDKIAGVKDQYFVEDIKTRIIS ILDQLLMKWITREGKDMFNLQANAFDIAKGIQEDLDMQLISDGMTVTGFQIMSFNYPQ EVQDMITKNASYGMVGDVNRYQQISMTDGMASGKMSGSGAASDMAGMMMGMNMANQMM NQMNQNQQAQSSGPQSTGSGSKPNFCPNCGTKTGEANFCPNCGQKLV*" /label="ydjI CDS" gene 574383..575354 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /label="ydjI gene" downshifts 575344 /Source="Nicolas_upshifts" /id="D300" /incds=0 /nref=180 /ntot=247 /MaxReadThrough="2.71622" /MaxDrop="5.81579" /score="16.72046" /energy="-11.1" /TU="U477" /idTUdmin="U477" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 575388 /Source="Nicolas_upshifts" /id="D301" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="2.13813" /MaxDrop="3.25329" /score="16.72046" /energy="-11.1" /TU="NA" /idTUdmin="U477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(575401..576426) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane associated potassium channel; prophage region 3" /protein_id="NP_388503.1" /db_xref="EnsemblGenomes-Gn:BSU06220" /db_xref="EnsemblGenomes-Tr:CAB12441" /db_xref="GOA:O34733" /db_xref="InterPro:IPR013099" /db_xref="SubtiList:BG12801" /db_xref="UniProtKB/Swiss-Prot:O34733" /translation="MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWK GCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASW SDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQK RSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYH STQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHP AEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAI GNAYSPK*" /label="ydjJ CDS" gene complement(575401..576426) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /label="ydjJ gene" promotor_-10 complement(576458..576477) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(576476) /Source="Nicolas_upshifts" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(576491..576497) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 576686..576693 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 576706 /Source="Nicolas_upshifts" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="upshifts" S_feature 576708..577010 /Source="Nicolas_S_feature" /locus_tag="new_676139_676441" /HighExp="M0t90, M40t90, Lbtran, T0.30H, BI, T1.0H, M9-stat, S1, T1.30H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.28450700000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S222" promotor_-10 576708..576727 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 577011..578432 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="myo-inositol transporter" /protein_id="NP_388504.1" /db_xref="EnsemblGenomes-Gn:BSU06230" /db_xref="EnsemblGenomes-Tr:CAB12442" /db_xref="GOA:O34718" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12802" /db_xref="UniProtKB/Swiss-Prot:O34718" /translation="MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQ LNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPN VTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNA ILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIR DEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIM YYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTA LLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMG VTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQ LEENFRAYDHSGAKKDSGAEVIG*" /label="iolT CDS" gene 577011..578432 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /label="iolT gene" downshifts 578424 /Source="Nicolas_upshifts" /id="D302" /incds=0 /nref=11 /ntot=24 /MaxReadThrough="2.82455" /MaxDrop="8.02371" /score="11.3880907" /energy="-11.2" /TU="NA" /idTUdmin="U479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(578480) /Source="Nicolas_upshifts" /id="D303" /incds=0 /nref=242 /ntot=272 /MaxReadThrough="1.00274" /MaxDrop="9.32541" /score="13.6781112" /energy="-11.2" /TU="NA" /idTUdmin="U482" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(578480..579520) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /EC_number="1.1.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12469342, 18820069, 24525333, 26428232, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin reductase/2,3-butanediol dehydrogenase" /protein_id="NP_388505.1" /db_xref="EnsemblGenomes-Gn:BSU06240" /db_xref="EnsemblGenomes-Tr:CAB12443" /db_xref="GOA:O34788" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12803" /db_xref="UniProtKB/Swiss-Prot:O34788" /translation="MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEY LGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHG HQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVD PSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIH PNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIK EKSQVKILVRPN*" /label="bdhA CDS" gene complement(578480..579520) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /label="bdhA gene" promotor_-35 579060..579069 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 579083..579102 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 579084..579619 /Source="Nicolas_S_feature" /locus_tag="new_678515_679050" /HighExp="C30, Gly, S6, C90, S8, BT, S7, Sw, Fru, Lbstat" /AntisenseName="bdhA" /AntisenseCor="-0.174163895138467" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S223" upshifts 579084 /Source="Nicolas_upshifts" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(579521..579815) /Source="Nicolas_S_feature" /locus_tag="new_678952_679246_c" /HighExp="Lbtran, BI, T1.0H, M40t90, LBGstat, LoTm, T0.30H, LPhT, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S224" misc_feature 579620..579639 /Source="Nicolas_upshift_promotors" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 579621..579918 /Source="Nicolas_S_feature" /locus_tag="new_679052_679349" /HighExp="G180, Paraq, Oxctl, H2O2, G135, G150, MG 5, C30, UNK1, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S225" upshifts 579621 /Source="Nicolas_upshifts" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="upshifts" misc_feature complement(579810..579824) /Source="Nicolas_upshift_promotors" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(579815) /Source="Nicolas_upshifts" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 579917..579936 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 579920 /Source="Nicolas_upshifts" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="upshifts" CDS 579959..580330 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /experiment="publication(s) with functional evidences, PMID:17581128, 20487291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17581128, 20487291; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein involved in cell wall metabolism" /protein_id="NP_388506.1" /db_xref="EnsemblGenomes-Gn:BSU06250" /db_xref="EnsemblGenomes-Tr:CAB12444" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG11036" /db_xref="UniProtKB/Swiss-Prot:P40775" /translation="MLKKVILAAFILVGSTLGAFSFSSDASAKHVNGNITWYNGVGKK GSSGKKLGHWDCATKIGFDVPRNGTKIRAYAKAKPKKVITVYKNDVGRMPNAVLDVSP KAFKALGYPLSKGKVAGHYSY*" /label="walM CDS" gene 579959..580330 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /label="walM gene" downshifts 580316 /Source="Nicolas_upshifts" /id="D304" /incds=0 /nref=5 /ntot=52 /MaxReadThrough="5.74148" /MaxDrop="2.8439" /score="-1.55787542" /energy="-7.4" /TU="U483" /idTUdmin="U481" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS 580396..581442 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388507.1" /db_xref="EnsemblGenomes-Gn:BSU06260" /db_xref="EnsemblGenomes-Tr:CAB12445" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12804" /db_xref="UniProtKB/Swiss-Prot:O34353" /translation="MKKRIILLLAVIIAAAAAGVAFYVAKDKGHEKAADVSVNTESGD ELLVSITDTDLLTKYYENDKVIHEEKLTSYPAFALDQKQQVLYYTGNNEQNEMRLFKL DLKSHKKTMLYKGAESADSLFLSKDRSTIYFRLGKADESNFRIAAFDLKTKKYKNLYP AANDQDDTVSSFFYNQKNDSFALLHYSVEEDYKKTDEANEKGIDPEPTTIHFAEGRQN KFNELKSLNQFISDIAVSDDDKRILFTSYTQKGTEQTASIQMLNADTKKYESIISNQK SFKLLIDAQPQFSKDGKNIYFLAEAKGAKKLKDETGREAKVRTIYSYSLENKTFKKVW ENPNGIINSFFVIN*" /label="ydjN CDS" gene 580396..581442 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /label="ydjN gene" downshifts 581416 /Source="Nicolas_upshifts" /id="D305" /incds=0 /nref=41 /ntot=177 /MaxReadThrough="1.73572" /MaxDrop="4.49184" /score="21.8200083" /energy="-13.9" /TU="NA" /idTUdmin="U483" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(581476..581634) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097689.1" /db_xref="EnsemblGenomes-Gn:BSU06269" /db_xref="EnsemblGenomes-Tr:CAX52576" /db_xref="GOA:O24817" /db_xref="UniProtKB/Swiss-Prot:O24817" /translation="MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLG SLALHLIH*" /label="ydzJ CDS" gene complement(581476..581634) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /label="ydzJ gene" downshifts complement(581492) /Source="Nicolas_upshifts" /id="D306" /incds=0 /nref=23 /ntot=155 /MaxReadThrough="0.7906" /MaxDrop="3.61386" /score="9.10659473" /energy="-10.1" /TU="NA" /idTUdmin="U487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(581691..581823) /Source="Nicolas_S_feature" /locus_tag="new_681122_681254_c" /HighExp="LoTm, S8, S5, S6, S4, B36, S7, Cold, B60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigWXY" /TUshortPSig="0.994, 1, 1" /TUlongSig="SigK" /TUlongPSig="0.994" /label="S226" downshifts complement(581734) /Source="Nicolas_upshifts" /id="D307" /incds=0 /nref=57 /ntot=272 /MaxReadThrough="3.03092" /MaxDrop="6.46708" /score="5.41743429" /energy="-8.4" /TU="U484,U486,U487" /idTUdmin="U484" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(581824..582033) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28197687" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388508.1" /db_xref="EnsemblGenomes-Gn:BSU06270" /db_xref="EnsemblGenomes-Tr:CAB12446" /db_xref="InterPro:IPR025916" /db_xref="SubtiList:BG12805" /db_xref="UniProtKB/Swiss-Prot:O34759" /translation="MSYYNKRNQEPLPKEDVSTWECTKEDCNGWTRKNFASSDTPLCP LCGSKMVDGIRSLVNLQNNSQTKTS*" /label="ydjO CDS" gene complement(581824..582033) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /label="ydjO gene" promotor_-10 complement(582066..582085) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582077) /Source="Nicolas_upshifts" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" CDS complement(582116..582931) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9987136; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacrylate hydrolase" /protein_id="NP_388509.1" /db_xref="EnsemblGenomes-Gn:BSU06280" /db_xref="EnsemblGenomes-Tr:CAB12447" /db_xref="GOA:O34592" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12806" /db_xref="UniProtKB/Swiss-Prot:O34592" /translation="MPYIILEDQTRLYYETHGSGTPILFIHGVLMSGQFFHKQFSVLS ANYQCIRLDLRGHGESDKVLHGHTISQYARDIREFLNAMELDHVVLAGWSMGAFVVWD YLNQFGNDNIQAAVIIDQSASDYQWEGWEHGPFDFDGLKTAMHAIQTDPLPFYESFIQ NMFAEPPAETETEWMLAEILKQPAAISSTILFNQTAADYRGTLQNINVPALLCFGEDK KFFSTAAGEHLRSNIPNATLVTFPKSSHCPFLEEPDAFNSTLLSFLDGVIGKS*" /label="ydjP CDS" gene complement(582116..582931) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /label="ydjP gene" promotor_-35 582758..582767 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 582780..582799 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 582780 /Source="Nicolas_upshifts" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(582944..583933) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388510.1" /db_xref="EnsemblGenomes-Gn:BSU06290" /db_xref="EnsemblGenomes-Tr:CAB12448" /db_xref="InterPro:IPR025062" /db_xref="SubtiList:BG12210" /db_xref="UniProtKB/Swiss-Prot:O34803" /translation="MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVN KREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYN EMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVP LAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSAC KQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFK IAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN*" /label="yeaA CDS" gene complement(582944..583933) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /label="yeaA gene" promotor_-10 complement(583798..583816) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(583806) /Source="Nicolas_upshifts" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(583832..583837) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(583955..583970) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(583976) /Source="Nicolas_upshifts" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(583982..583991) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(584031..585572) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /EC_number="1.3.3.5" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="outer spore coat copper-dependent promiscuous laccase" /protein_id="NP_388511.1" /db_xref="EnsemblGenomes-Gn:BSU06300" /db_xref="EnsemblGenomes-Tr:CAB12449" /db_xref="GOA:P07788" /db_xref="InterPro:IPR001117" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011706" /db_xref="InterPro:IPR011707" /db_xref="PDB:1GSK" /db_xref="PDB:1OF0" /db_xref="PDB:1W6L" /db_xref="PDB:1W6W" /db_xref="PDB:1W8E" /db_xref="PDB:2BHF" /db_xref="PDB:2WSD" /db_xref="PDB:2X87" /db_xref="PDB:2X88" /db_xref="PDB:3ZDW" /db_xref="PDB:4A66" /db_xref="PDB:4A67" /db_xref="PDB:4A68" /db_xref="PDB:4AKO" /db_xref="PDB:4AKP" /db_xref="PDB:4AKQ" /db_xref="PDB:4Q89" /db_xref="PDB:4Q8B" /db_xref="PDB:4YVN" /db_xref="PDB:4YVU" /db_xref="SubtiList:BG10490" /db_xref="UniProtKB/Swiss-Prot:P07788" /translation="MTLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLP PTRLWGYNGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHSDSQHEEPEVKT VVHLHGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAMALT RLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLFYPSAPENPSPS LPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINASNTRTYNLSLDNGGDFIQI GSDGGLLPRSVKLNSFSLAPAERYDIIIDFTAYEGESIILANSAGCGGDVNPETDANI MQFRVTKPLAQKDESRKPKYLASYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKR WHDPVTETPKVGTTEIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYT GPAVPPPPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMDI TDPHK*" /label="cotA CDS" gene complement(584031..585572) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /label="cotA gene" downshifts complement(584044) /Source="Nicolas_upshifts" /id="D308" /incds=0 /nref=46 /ntot=93 /MaxReadThrough="2.97674" /MaxDrop="5.60726" /score="22.3755425" /energy="-9.1" /TU="U488" /idTUdmin="U488" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(585603..585622) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-10" upshifts complement(585617) /Source="Nicolas_upshifts" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="upshifts" promotor_-35 complement(585636..585645) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-35" CDS complement(585724..587133) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16547045, 16850406, 8951816, 9677314, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16547045, 16850406, 8951816, 9677314, 24142252; Product type t : transporter" /codon_start=1 /transl_table=11 /product="gamma-aminobutyrate (GABA) permease; proline permease" /protein_id="NP_388512.2" /db_xref="EnsemblGenomes-Gn:BSU06310" /db_xref="EnsemblGenomes-Tr:CAB12450" /db_xref="GOA:P46349" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="InterPro:IPR011265" /db_xref="SubtiList:BG11328" /db_xref="UniProtKB/Swiss-Prot:P46349" /translation="MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPG AVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVI VIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIV AIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEH IGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQA IVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPE ALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRK VSEKAAANPVTQQQPDILP*" /label="gabP CDS" gene complement(585724..587133) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /label="gabP gene" downshifts complement(585738) /Source="Nicolas_upshifts" /id="D309" /incds=0 /nref=124 /ntot=216 /MaxReadThrough="3.22899" /MaxDrop="5.0359" /score="18.985683" /energy="-13.5" /TU="U489" /idTUdmin="U489" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(587171..587458) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097690.1" /db_xref="EnsemblGenomes-Gn:BSU06319" /db_xref="EnsemblGenomes-Tr:CAX52577" /db_xref="UniProtKB/Swiss-Prot:C0H3X2" /translation="MIHPPQKNSDEGTLFLSSNLFAPPKIPSNPRTPVLLAFYRIVNI TQNHTANKKRNIFSTHSLKAQTKHYKFEISWYIFLHEFSTNCIFMIEFQLS*" /label="ydzX CDS" gene complement(587171..587458) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /label="ydzX gene" misc_feature complement(587174..587193) /Source="Nicolas_upshift_promotors" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(587188) /Source="Nicolas_upshifts" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="upshifts" promotor_-35 587464..587471 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 587487..587506 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 587488 /Source="Nicolas_upshifts" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="upshifts" CDS 587531..588403 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="secondary Mn(II) exporter, promiscuous" /protein_id="NP_388513.1" /db_xref="EnsemblGenomes-Gn:BSU06320" /db_xref="EnsemblGenomes-Tr:CAB12451" /db_xref="GOA:P46348" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11329" /db_xref="UniProtKB/Swiss-Prot:P46348" /translation="MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADG LNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSA GESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAF VSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAY KQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHA IDYSHVHMEPLEQK*" /label="mneS CDS" gene 587531..588403 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /label="mneS gene" downshifts 588368 /Source="Nicolas_upshifts" /id="D310" /incds=0 /nref=2 /ntot=88 /MaxReadThrough="1.72291" /MaxDrop="2.86431" /score="24.8167732" /energy="-10.2" /TU="U490" /idTUdmin="U490" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(588643) /Source="Nicolas_upshifts" /id="D311" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="0.65827" /MaxDrop="3.33542" /score="-0.424989042" /energy="-12.9" /TU="NA" /idTUdmin="U489" /TUdmin="-3015" /isTUend="FALSE" /label="downshifts" misc_feature 588697..588716 /Source="Nicolas_upshift_promotors" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 588707 /Source="Nicolas_upshifts" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="upshifts" CDS 588753..589715 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21907250, 26933057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative MoxR-like ATPase" /protein_id="NP_388514.2" /db_xref="EnsemblGenomes-Gn:BSU06330" /db_xref="EnsemblGenomes-Tr:CAB12452" /db_xref="GOA:P94474" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12211" /db_xref="UniProtKB/Swiss-Prot:P94474" /translation="MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLL EDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIM GNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYP LPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNV RADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQY LAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR*" /label="yeaC CDS" gene 588753..589715 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /label="yeaC gene" CDS 589715..590911 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388515.2" /db_xref="EnsemblGenomes-Gn:BSU06340" /db_xref="EnsemblGenomes-Tr:CAB12453" /db_xref="InterPro:IPR002881" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12212" /db_xref="UniProtKB/Swiss-Prot:P94475" /translation="MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFL PFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLP EGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKT AFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFA ALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAG AGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQ VVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGG RVSRVV*" /label="yeaD CDS" gene 589715..590911 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /label="yeaD gene" CDS 590933..593146 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388516.2" /db_xref="EnsemblGenomes-Gn:BSU06350" /db_xref="EnsemblGenomes-Tr:CAB12454" /db_xref="GOA:P94476" /db_xref="InterPro:IPR002931" /db_xref="InterPro:IPR025403" /db_xref="InterPro:IPR036985" /db_xref="SubtiList:BG12213" /db_xref="UniProtKB/Swiss-Prot:P94476" /translation="MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFS VFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNIT LIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFT PYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFG LAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQG KERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKH YGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYK LDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYL GSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGY TSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKD SGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAV LAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSE TLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS*" /label="yebA CDS" gene 590933..593146 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /label="yebA gene" promotor_-35 593141..593148 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 593163..593182 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 593179..593308 /Source="Nicolas_S_feature" /locus_tag="new_692610_692739" /HighExp="G180, Oxctl, G135, LBGexp, G150, Paraq, C30, LPh, MG 25, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63292099999999996" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S227" upshifts 593179 /Source="Nicolas_upshifts" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="upshifts" CDS 593309..594850 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /EC_number="6.3.5.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1312531, 21856856; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP synthetase" /protein_id="NP_388517.2" /db_xref="EnsemblGenomes-Gn:BSU06360" /db_xref="EnsemblGenomes-Tr:CAB12455" /db_xref="GOA:P29727" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022955" /db_xref="InterPro:IPR025777" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10647" /db_xref="UniProtKB/Swiss-Prot:P29727" /translation="MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEE IKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAA SQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS KADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGD KQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNV IKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIE SGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFP GPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGD ARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPA TIEWE*" /label="guaA CDS" gene 593309..594850 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /label="guaA gene" downshifts 594836 /Source="Nicolas_upshifts" /id="D312" /incds=0 /nref=247 /ntot=268 /MaxReadThrough="2.12151" /MaxDrop="7.3702" /score="22.5795134" /energy="-18.5" /TU="NA" /idTUdmin="U492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 594957..594961 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-35" promotor_-10 594977..594996 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-10" upshifts 594987 /Source="Nicolas_upshifts" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="upshifts" misc_RNA 594994..595096 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswC RNA" gene 594994..595096 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /label="gswC gene" downshifts 595122 /Source="Nicolas_upshifts" /id="D313" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="8.01916" /MaxDrop="4.7859" /score="24.3821572" /energy="-11.3" /TU="U493" /idTUdmin="U492" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 595231..596553 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3110131, 11591660, 12923093, 15849754, 16850406, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 11591660, 12923093, 15849754, 16850406, 19446032; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_388518.1" /db_xref="EnsemblGenomes-Gn:BSU06370" /db_xref="EnsemblGenomes-Tr:CAB12456" /db_xref="GOA:O34987" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG12811" /db_xref="UniProtKB/Swiss-Prot:O34987" /translation="MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESV KDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMG ISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSG IITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGL VPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQ AGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTG ILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMP LTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK*" /label="pbuG CDS" gene 595231..596553 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /label="pbuG gene" downshifts 596531 /Source="Nicolas_upshifts" /id="D314" /incds=0 /nref=47 /ntot=153 /MaxReadThrough="4.18958" /MaxDrop="4.86237" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 596574 /Source="Nicolas_upshifts" /id="D315" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="3.09696" /MaxDrop="3.87785" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-43" /isTUend="FALSE" /label="downshifts" promotor_-35 596603..596612 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 596623..596763 /Source="Nicolas_S_feature" /locus_tag="new_696054_696194" /HighExp="T1.30H, T1.0H, T2.0H, T0.30H, B60, T2.30H, T-0.40H, T0.0H, T3.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S228" upshifts 596623 /Source="Nicolas_upshifts" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 596625..596640 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 596764..597567 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388519.2" /db_xref="EnsemblGenomes-Gn:BSU06380" /db_xref="EnsemblGenomes-Tr:CAB12457" /db_xref="GOA:O34341" /db_xref="SubtiList:BG12812" /db_xref="UniProtKB/Swiss-Prot:O34341" /translation="MTEERKETFEEEINQSERIDADEEPLSRMSRKASRQSKQKQKQK QKPRQERGESTVKDKLASVWAAINRYCGFAFSILKSPAKTVVTDGFSHYKYGLISMLI FSIIFSIGNWFQLKASWNRPLGFGERHHAFYDGFLVVLVYLLIFFAVMVFAIWAVSRY MMKQKVTFREAAAVLGSLLVPVIAVSILWLIFAIVNIPMLTVLFTVLILFSIFFIIAL YVQRVYQAAQDAPIDYIYCVFAVVAIALLFTAVTWPFISEYITASLIPL*" /label="yebC CDS" gene 596764..597567 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /label="yebC gene" downshifts 597552 /Source="Nicolas_upshifts" /id="D316" /incds=0 /nref=218 /ntot=263 /MaxReadThrough="1.47691" /MaxDrop="7.03926" /score="33.0377004" /energy="-10.7" /TU="NA" /idTUdmin="U494" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 597635..597642 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 597656..597675 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 597662..597725 /Source="Nicolas_S_feature" /locus_tag="new_697093_697156" /HighExp="B60, S2, S7, S8, Lbstat, nit, S4, BC, BT, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S229" upshifts 597662 /Source="Nicolas_upshifts" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="upshifts" CDS 597726..597893 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388520.3" /db_xref="EnsemblGenomes-Gn:BSU06390" /db_xref="EnsemblGenomes-Tr:CAB12458" /db_xref="InterPro:IPR025072" /db_xref="SubtiList:BG12813" /db_xref="UniProtKB/Swiss-Prot:O34904" /translation="MADVLRRAINQKKQFLKTKLLLSEFYQGRGEQLADYTLSELEKE YKSLQKMKKEI*" /label="yebD CDS" gene 597726..597893 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /label="yebD gene" downshifts 597900 /Source="Nicolas_upshifts" /id="D317" /incds=0 /nref=64 /ntot=163 /MaxReadThrough="2.85884" /MaxDrop="5.66286" /score="29.2645456" /energy="-9" /TU="NA" /idTUdmin="U495" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 597944..597950 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 597965..597983 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 597968..598054 /Source="Nicolas_S_feature" /locus_tag="new_697399_697485" /HighExp="Etha, Gly, M9-stat, Sw, B60, S4, S6, LPhT, S3, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S230" upshifts 597968 /Source="Nicolas_upshifts" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 598033..598040 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 598054..598073 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 598056 /Source="Nicolas_upshifts" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="upshifts" CDS 598107..598661 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388521.2" /db_xref="EnsemblGenomes-Gn:BSU06400" /db_xref="EnsemblGenomes-Tr:CAB12459" /db_xref="GOA:O34624" /db_xref="InterPro:IPR019264" /db_xref="InterPro:IPR022930" /db_xref="SubtiList:BG12814" /db_xref="UniProtKB/Swiss-Prot:O34624" /translation="MMQTILSNGIAMVLIILIINIVYVSFFTIRMILTLKGQRYLAAG ISTIEILVYVTGLSLVLDNLDQIQNVIAYALGYGLGVIVGMKIEEKLALGYIMVNVIT KELDLDLPKQLREKGYGVTNWVAGGLEGDRTALQILTPRRYELQLYDTIKTLDSKAFI IAYEPKTIHGGFWVKAVKKRRIKE*" /label="yebE CDS" gene 598107..598661 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /label="yebE gene" CDS 598661..598858 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388523.1" /db_xref="EnsemblGenomes-Gn:BSU06410" /db_xref="EnsemblGenomes-Tr:CAB12461" /db_xref="InterPro:IPR025930" /db_xref="SubtiList:BG12816" /db_xref="UniProtKB/Swiss-Prot:O34700" /translation="MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKK ENGSIQIVPCGKKIVFEGKLI*" /label="yebG CDS" gene 598661..598858 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /label="yebG gene" downshifts 598848 /Source="Nicolas_upshifts" /id="D318" /incds=0 /nref=2 /ntot=91 /MaxReadThrough="2.80904" /MaxDrop="2.65424" /score="17.462689" /energy="-17.6" /TU="U496" /idTUdmin="U497" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 598904..598911 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 598926..598945 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 598928 /Source="Nicolas_upshifts" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 598938..599040 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswD RNA" gene 598938..599040 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /label="gswD gene" S_feature 599041..599180 /Source="Nicolas_S_feature" /locus_tag="new_698472_698611" /HighExp="MG 10, MG 15, MG t5, BMM, MG 25, MG 5, HPh, GM 45, GM 90, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S231" CDS 599181..599669 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /EC_number="5.4.99.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12787499, 16138311, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide mutase" /protein_id="NP_388524.1" /db_xref="EnsemblGenomes-Gn:BSU06420" /db_xref="EnsemblGenomes-Tr:CAB12462" /db_xref="GOA:P12044" /db_xref="InterPro:IPR000031" /db_xref="InterPro:IPR024694" /db_xref="InterPro:IPR033747" /db_xref="InterPro:IPR035893" /db_xref="SubtiList:BG10700" /db_xref="UniProtKB/Swiss-Prot:P12044" /translation="MQPLVGIIMGSTSDWETMKHACDILDELNVPYEKKVVSAHRTPD FMFEYAETARERGIKVIIAGAGGAAHLPGMTAAKTTLPVIGVPVQSKALNGMDSLLSI VQMPGGVPVATTSIGKAGAVNAGLLAAQILSAFDEDLARKLDERRENTKQTVLESSDQ LV*" /label="purE CDS" gene 599181..599669 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /label="purE gene" CDS 599662..600804 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /EC_number="6.3.4.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8998996, 9683488, 21931218, 25372694; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide synthase" /protein_id="NP_388525.2" /db_xref="EnsemblGenomes-Gn:BSU06430" /db_xref="EnsemblGenomes-Tr:CAB12463" /db_xref="GOA:P12045" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10701" /db_xref="UniProtKB/Swiss-Prot:P12045" /translation="MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDS PCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELL LITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQF VIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNI LFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHN SGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEA KLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE*" /label="purK CDS" gene 599662..600804 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /label="purK gene" CDS 600801..602096 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /EC_number="4.3.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9622500, 9683488, 9890879, 11063569, 12787499; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate lyase" /protein_id="NP_388526.1" /db_xref="EnsemblGenomes-Gn:BSU06440" /db_xref="EnsemblGenomes-Tr:CAB12464" /db_xref="GOA:P12047" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004769" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR019468" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="PDB:1F1O" /db_xref="SubtiList:BG10702" /db_xref="UniProtKB/Swiss-Prot:P12047" /translation="MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKED VKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTAL SYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEE MKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDR HADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSEN MTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNL TVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFREL VEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA*" /label="purB CDS" gene 600801..602096 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /label="purB gene" promotor_-10 complement(601106..601125) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(601127) /Source="Nicolas_upshifts" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(601140..601147) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 602170..602895 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /EC_number="6.3.2.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2495272, 9683488, 10784038, 12787499, 26118696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole succinocarboxamide synthetase" /protein_id="NP_388527.1" /db_xref="EnsemblGenomes-Gn:BSU06450" /db_xref="EnsemblGenomes-Tr:CAB12465" /db_xref="GOA:P12046" /db_xref="InterPro:IPR001636" /db_xref="InterPro:IPR018236" /db_xref="InterPro:IPR028923" /db_xref="InterPro:IPR033934" /db_xref="SubtiList:BG10703" /db_xref="UniProtKB/Swiss-Prot:P12046" /translation="MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAE ISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGS MSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIV NEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFR RNLGSLTDAYEEIFNRLGGIHHV*" /label="purC CDS" gene 602170..602895 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /label="purC gene" CDS 602888..603142 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10784038, 12787499" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10784038, 12787499; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for phosphoribosylformylglycinamidine synthetase activity" /protein_id="NP_388528.1" /db_xref="EnsemblGenomes-Gn:BSU06460" /db_xref="EnsemblGenomes-Tr:CAB12466" /db_xref="GOA:P12049" /db_xref="InterPro:IPR003850" /db_xref="InterPro:IPR036604" /db_xref="PDB:1T4A" /db_xref="PDB:1TWJ" /db_xref="SubtiList:BG10704" /db_xref="UniProtKB/Swiss-Prot:P12049" /translation="MYKVKVYVSLKESVLDPQGSAVQHALHSMTYNEVQDVRIGKYME LTIEKSDRDLDVLVKEMCEKLLANTVIEDYRYEVEEVVAQ*" /label="purS CDS" gene 602888..603142 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /label="purS gene" CDS 603139..603822 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301530, 15301532, 10784038, 9683488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301530, 15301532, 10784038, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit I" /protein_id="NP_388529.1" /db_xref="EnsemblGenomes-Gn:BSU06470" /db_xref="EnsemblGenomes-Tr:CAB12467" /db_xref="GOA:P12041" /db_xref="InterPro:IPR010075" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10706" /db_xref="UniProtKB/Swiss-Prot:P12041" /translation="MKFAVIVLPGSNCDIDMYHAVKDELGHEVEYVWHEETSLDGFDG VLIPGGFSYGDYLRCGAIARFANIMPAVKQAAAEGKPVLGVCNGFQILQELGLLPGAM RRNKDLKFICRPVELIVQNDETLFTASYEKGESITIPVAHGEGNFYCDDETLATLKEN NQIAFTYGSNINGSVSDIAGVVNEKGNVLGMMPHPERAVDELLGSADGLKLFQSIVKN WRETHVTTA*" /label="purQ CDS" gene 603139..603822 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /label="purQ gene" CDS 603806..606034 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301532, 10784038, 9683488, 21671997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301532, 10784038, 9683488, 21671997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit II" /protein_id="NP_388530.2" /db_xref="EnsemblGenomes-Gn:BSU06480" /db_xref="EnsemblGenomes-Tr:CAB12468" /db_xref="GOA:P12042" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10705" /db_xref="UniProtKB/Swiss-Prot:P12042" /translation="MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEI GIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNH PSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG YGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKT GRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGA AGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEI IDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYR EFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLR IRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPE KPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTA HITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLD AIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVK KEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKS KA*" /label="purL CDS" gene 603806..606034 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /label="purL gene" downshifts complement(604054) /Source="Nicolas_upshifts" /id="D319" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="0.69202" /MaxDrop="3.99287" /score="-6.56256716" /energy="-16.7" /TU="NA" /idTUdmin="U499" /TUdmin="-3147" /isTUend="FALSE" /label="downshifts" CDS 606010..607440 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /EC_number="2.4.2.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 10049369, 12787499, 16321950, 17981983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 10049369, 12787499, 16321950, 17981983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine phosphoribosylpyrophosphate amidotransferase" /protein_id="NP_388531.2" /db_xref="EnsemblGenomes-Gn:BSU06490" /db_xref="EnsemblGenomes-Tr:CAB12469" /db_xref="GOA:P00497" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005854" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR035584" /db_xref="PDB:1AO0" /db_xref="PDB:1GPH" /db_xref="SubtiList:BG10707" /db_xref="UniProtKB/Swiss-Prot:P00497" /translation="MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGI VATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRS QNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKN SLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLR EVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKM LAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQ GVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHP CFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLA CFTGKYPTEIYQDTVLPHVKEAVLTK*" /label="purF CDS" gene 606010..607440 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /label="purF gene" S_feature 607441..607541 /Source="Nicolas_S_feature" /locus_tag="new_706872_706972" /HighExp="MG 15, MG 25, MG 10, MG 5, aero, S0, MG t5, Gly, LPh, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S232" CDS 607542..608582 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /EC_number="6.3.3.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10508786, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole synthetase" /protein_id="NP_388532.2" /db_xref="EnsemblGenomes-Gn:BSU06500" /db_xref="EnsemblGenomes-Tr:CAB12470" /db_xref="GOA:P12043" /db_xref="InterPro:IPR004733" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10708" /db_xref="UniProtKB/Swiss-Prot:P12043" /translation="MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGM FDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFF LDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGV AEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLG EELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIP PIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKK GEGVTFGGAALS*" /label="purM CDS" gene 607542..608582 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /label="purM gene" CDS 608579..609166 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /EC_number="2.1.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10569930, 12787499, 19574646; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase" /protein_id="NP_388533.2" /db_xref="EnsemblGenomes-Gn:BSU06510" /db_xref="EnsemblGenomes-Tr:CAB12471" /db_xref="GOA:P12040" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR004607" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG10709" /db_xref="UniProtKB/Swiss-Prot:P12040" /translation="MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVI ERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYG GKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEH DTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA*" /label="purN CDS" gene 608579..609166 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /label="purN gene" misc_feature 608589..608603 /Source="Nicolas_upshift_promotors" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 608598 /Source="Nicolas_upshifts" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(608865..608883) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(608872) /Source="Nicolas_upshifts" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(608899..608904) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 609163..610701 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787499, 1937050, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase" /protein_id="NP_388534.2" /db_xref="EnsemblGenomes-Gn:BSU06520" /db_xref="EnsemblGenomes-Tr:CAB12472" /db_xref="GOA:P12048" /db_xref="InterPro:IPR002695" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024051" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10710" /db_xref="UniProtKB/Swiss-Prot:P12048" /translation="MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENG VDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVN LYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE EGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGEN PHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHM NPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSF SQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTK REPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEK AKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIR HFKH*" /label="purH CDS" gene 609163..610701 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /label="purH gene" CDS 610717..611985 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /EC_number="6.3.4.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 12787499, 16321950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide synthetase" /protein_id="NP_388535.1" /db_xref="EnsemblGenomes-Gn:BSU06530" /db_xref="EnsemblGenomes-Tr:CAB12473" /db_xref="GOA:P12039" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR020559" /db_xref="InterPro:IPR020560" /db_xref="InterPro:IPR020561" /db_xref="InterPro:IPR020562" /db_xref="InterPro:IPR037123" /db_xref="PDB:2XCL" /db_xref="PDB:2XD4" /db_xref="SubtiList:BG10711" /db_xref="UniProtKB/Swiss-Prot:P12039" /translation="MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLV NIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGS KQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEE EAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFD GDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTE NGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASE GYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARD RVYKAVDEIFKPGLFFRKDIGARALKAAQK*" /label="purD CDS" gene 610717..611985 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /label="purD gene" downshifts 611970 /Source="Nicolas_upshifts" /id="D320" /incds=0 /nref=140 /ntot=249 /MaxReadThrough="2.77191" /MaxDrop="5.90939" /score="30.0999687" /energy="-11.4" /TU="NA" /idTUdmin="U500" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(612025..612444) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388536.2" /db_xref="EnsemblGenomes-Gn:BSU06540" /db_xref="EnsemblGenomes-Tr:CAB12474" /db_xref="GOA:O31497" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12874" /db_xref="UniProtKB/Swiss-Prot:O31497" /translation="MDDTDLQILSHLQRNGRLTMVELGKLVGLSSPSAAERVRKLEDK GVITGYSANICYEKLNKHVTAFILMEPKSCKHYAAFATSHPDVAENHRITGMYSYVTK VVTESVHTLEDFIDTSMAHGKPTTLVVLSSSSCHPAF*" /label="yezC CDS" gene complement(612025..612444) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /label="yezC gene" misc_feature complement(612514..612533) /Source="Nicolas_upshift_promotors" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(612523) /Source="Nicolas_upshifts" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="upshifts" CDS 612588..613862 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26319875, 27723097, 24678831; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_388537.2" /db_xref="EnsemblGenomes-Gn:BSU06550" /db_xref="EnsemblGenomes-Tr:CAB12475" /db_xref="GOA:O34560" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12817" /db_xref="UniProtKB/Swiss-Prot:O34560" /translation="MLPELQRSITWIQGTALTIGAVLGCGILILPSVTADTAGPASLF VWVFMSFLSFFLVGTLARLVKIAPSAGGITAYVQLAFQKKAGAILGWIMLGSVPIGVP IIALTGAHYVSYITEAADWQITLIAGCMLAISILLHMRGIQLSANISTLVICVIVFLL VTSIAVSLPHVTIAEFKPFLPHGWSAAGSVSVMIFFSFVGWEMITPLAEEFHRPEKDV PLSLFLAASCVAGLYIMLSFVTVGTHSYGENGEIASLAMLISKGAGESGVYVTVCLAL FITFATIHANIAGFSRMVYALAREGHIPVFFGKLSATKRTPIRVLTAMAAVFGLVLAA HGLFQIDLTTLLKGPSAAFIASYICTMAAALKLLGRRDIGWWMALGAFVACAVIYSFS GWALLYPAVLAAAGYFYMKTKGGHKKKLDHVL*" /label="yecA CDS" gene 612588..613862 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /label="yecA gene" downshifts 613811 /Source="Nicolas_upshifts" /id="D321" /incds=0 /nref=4 /ntot=64 /MaxReadThrough="0.796809999999999" /MaxDrop="2.92696" /score="1.68718502" /energy="-14.2" /TU="NA" /idTUdmin="U498" /TUdmin=1825 /isTUend="FALSE" /label="downshifts" CDS complement(613877..614104) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097691.1" /db_xref="EnsemblGenomes-Gn:BSU06559" /db_xref="EnsemblGenomes-Tr:CAX52578" /db_xref="GOA:C0H3X3" /db_xref="InterPro:IPR021309" /db_xref="UniProtKB/Swiss-Prot:C0H3X3" /translation="MKPNISLINAVFRIACGLTIMSAASAKFTKKPWCRMHLFYIFMG AMKAGSGILRFCPVTYMFQHSDSGNNEHQNG*" /label="yezF CDS" gene complement(613877..614104) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /label="yezF gene" downshifts complement(613888) /Source="Nicolas_upshifts" /id="D322" /incds=0 /nref=29 /ntot=46 /MaxReadThrough="0.14199" /MaxDrop="6.82335" /score="34.1397958" /energy="-13.9" /TU="NA" /idTUdmin="U504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(614105..614525) /Source="Nicolas_S_feature" /locus_tag="new_713536_713956_c" /HighExp="S8, S7, S5, S6, S4, ferm, nit, BT, Pyr, T5.0H" /AntisenseName="yerA" /AntisenseCor="0.38264258041500998" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S233" promotor_-35 614172..614177 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 614188 /Source="Nicolas_upshifts" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 614191..614210 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 614233..615975 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23109554; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenine deaminase YerA" /protein_id="NP_388538.1" /db_xref="EnsemblGenomes-Gn:BSU06560" /db_xref="EnsemblGenomes-Tr:CAB12476" /db_xref="GOA:O34909" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG12829" /db_xref="UniProtKB/Swiss-Prot:O34909" /translation="MSERTFNWKNKDIRAQVDVVDSKLLPTLLLRNALVLNPYVKQWL KKNIWIYQDRIVYVGHELPNRAEEIHTIDCEGKYIVPGYIEPHAHPFQIYNPQTLAEY VSQYGTTTFVNDNLFLLLQSGKKKALTILNELKKQPVQYFWWSRYDLQTEVLNEDHVL PFDVRKQWIEHPDVIQGGEMTGWPRLVDGDDLMLHCMQATKKQRKRIEGHFPGASDKT LTKMKLFGADCDHEAMTGDEVMRRLELGYYVSLRNSSIRPDVRKILQELHEKGFRYYD HFFYTTDGATPNFYKGGMTNELIRIALEEGVPAIDAYNMASFNIAKYYQMDDYLGVVG PGRLASLNILEDPLNPNPVTVLSKGTILRENGCDLKAFTKTDWHKGGLVPLELSYDMT MDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMI KGFASSVQGFVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPL ALCGCASSEAYEDVLEKEQKLRDLLTERGYEFCDPIYTLLFLQSTHLPYIRITPRGIF DVMKKTVLFPSIMR*" /label="yerA CDS" gene 614233..615975 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /label="yerA gene" promotor_-10 complement(614510..614521) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(614525) /Source="Nicolas_upshifts" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(614535..614541) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 614556 /Source="Nicolas_upshifts" /id="D323" /incds=1 /nref=13 /ntot=109 /MaxReadThrough="7.92321" /MaxDrop="3.44855" /score="1.68718502" /energy="-14.2" /TU="U503" /idTUdmin="U498" /TUdmin=2570 /isTUend="FALSE" /label="downshifts" promotor_-35 615949..615955 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 615967 /Source="Nicolas_upshifts" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 615968..615987 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 616002..616997 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12073041; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388539.1" /db_xref="EnsemblGenomes-Gn:BSU06570" /db_xref="EnsemblGenomes-Tr:CAB12477" /db_xref="GOA:O34968" /db_xref="InterPro:IPR021416" /db_xref="InterPro:IPR023158" /db_xref="InterPro:IPR035328" /db_xref="PDB:2PSB" /db_xref="SubtiList:BG12830" /db_xref="UniProtKB/Swiss-Prot:O34968" /translation="MKKWMTVCALCFVFFLLVSCQQKDAVPDTAKKLKAPLTGLKTEQ KVTERRPVAVVVNNHPKARPQSGLSKADIVIEALAEGQITRFLAIFQSQMPETVGPVR SAREYFVTLSNGFDSIFVHHGWSPGAKKQLESGAADYMNGLDFDGSLFWRADFSKPPH NSYTSYDYIKKAAEQKGYKLKQETNPLLFQTSDAKPANESYNVRVDYGTNNVTNLVEY NYDKKAEFYTRSSDGVITTDRETGKPVAMQNIFIVEASHHIIDQDGRRDIDLESGGKG LLFQHGNVIETDWKQVNGRIVPVKDGKWLPFVPGKTWINIVPDLDAASISKGEGV*" /label="yerB CDS" gene 616002..616997 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /label="yerB gene" CDS 617000..617314 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor-histidine operons" /protein_id="NP_388540.1" /db_xref="EnsemblGenomes-Gn:BSU06580" /db_xref="EnsemblGenomes-Tr:CAB12478" /db_xref="GOA:Q7BVT7" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013368" /db_xref="SubtiList:BG12831" /db_xref="UniProtKB/Swiss-Prot:Q7BVT7" /translation="MQIDKLRGKELDQLFNSILSLKDLEECYRFFDDLCTINEIQSLA QRLEVARMLREGNTYHKIETETGASTATISRVKRCLNYGNDAYEMALDRVKETETESS SK*" /label="yerC CDS" gene 617000..617314 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /label="yerC gene" downshifts 617177 /Source="Nicolas_upshifts" /id="D324" /incds=1 /nref=1 /ntot=25 /MaxReadThrough="7.1005" /MaxDrop="2.3494" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" downshifts 617319 /Source="Nicolas_upshifts" /id="D325" /incds=0 /nref=78 /ntot=262 /MaxReadThrough="3.58776" /MaxDrop="5.59364" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-232" /isTUend="FALSE" /label="downshifts" CDS complement(617349..618926) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /EC_number="1.4.1.13" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15805528, 17114254, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative osmotic shock glutamate synthase subunit (flavoprotein subunit, ferredoxin-dependent)" /protein_id="NP_388541.1" /db_xref="EnsemblGenomes-Gn:BSU06590" /db_xref="EnsemblGenomes-Tr:CAB12479" /db_xref="GOA:O34849" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024188" /db_xref="InterPro:IPR027283" /db_xref="SubtiList:BG12832" /db_xref="UniProtKB/Swiss-Prot:O34849" /translation="METIIIALIAFIIGIIAIPIVLFAWIYIKDEKQQEHSILRNYPV IGRFRYILEKIGPELRQYLYSNDNEEQPFSRKEYEQTVISGKYKSRMMGFGSVRDFDK PGYYIRNAMFPKQREEMHVNQTPKIETQIYKMDADNLFKRKEHAEHIKADPYFLHPDD VQVIGEHTCEKPFYVKGLVGQSAMSYGSLGERAVTALSKGLHLAGGTWMNTGEGGLSE YHLKGGADIICQIGPGLFGVRKRNGEFSWEEFKRKSRIDQIKAFELKLAQGAKTRGGH VDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSNPPEMLDFIEKLRDVGQKPVGIKLVA GHPEELHELFSHMQKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPIVDTLL KQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCP AGVATTDPKLQKALSVEEKQHRVCNYVISLREGLFNLAAAAGINSPIHFSKEHVVYRK EDGSIINIDNLIHQFVS*" /label="yerD CDS" gene complement(617349..618926) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /label="yerD gene" downshifts complement(617363) /Source="Nicolas_upshifts" /id="D326" /incds=0 /nref=7 /ntot=24 /MaxReadThrough="2.99325" /MaxDrop="5.6389" /score="34.8793815" /energy="-15.8" /TU="U506" /idTUdmin="U506" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(618940..618959) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(618959) /Source="Nicolas_upshifts" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(618974..618980) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 619123..619126 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 619140 /Source="Nicolas_upshifts" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 619143..619162 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 619191..619877 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16377641, 21761520, 21214173, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16377641, 21761520, 21214173, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heptaprenylglyceryl-phosphate synthase" /protein_id="NP_388542.1" /db_xref="EnsemblGenomes-Gn:BSU06600" /db_xref="EnsemblGenomes-Tr:CAB12480" /db_xref="GOA:O34790" /db_xref="InterPro:IPR008205" /db_xref="PDB:1VIZ" /db_xref="PDB:3VZX" /db_xref="PDB:3VZY" /db_xref="PDB:3VZZ" /db_xref="PDB:3W00" /db_xref="SubtiList:BG12833" /db_xref="UniProtKB/Swiss-Prot:O34790" /translation="MYDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVT EDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFDLYFIPSVLNSKNADWIVGMHQKAMK EYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELLQLPIFYLE YSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRA LKTVAAVKGE*" /label="pcrB CDS" gene 619191..619877 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /label="pcrB gene" CDS 619939..622158 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 12682299, 14594837, 16267290, 26070154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_388543.1" /db_xref="EnsemblGenomes-Gn:BSU06610" /db_xref="EnsemblGenomes-Tr:CAB12481" /db_xref="GOA:O34580" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR005751" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG12834" /db_xref="UniProtKB/Swiss-Prot:O34580" /translation="MNYISNQLLSGLNPVQQEAVKTTDGPLLLMAGAGSGKTRVLTHR IAYLMAEKHVAPWNILAITFTNKAAREMKERVESILGPGADDIWISTFHSMCVRILRR DIDRIGINRNFSILDTADQLSVIKGILKERNLDPKKFDPRSILGTISSAKNELTEPEE FSKVAGGYYDQVVSDVYADYQKKLLKNQSLDFDDLIMTTIKLFDRVPEVLEFYQRKFQ YIHVDEYQDTNRAQYMLVKQLAERFQNLCVVGDSDQSIYRWRGADITNILSFEKDYPN ASVILLEQNYRSTKRILRAANEVIKNNSNRKPKNLWTENDEGIKISYYRGDNEFGEGQ FVAGKIHQLHSTGKRKLSDIAILYRTNAQSRVIEETLLKAGLNYNIVGGTKFYDRKEI KDILAYLRLVSNPDDDISFTRIVNVPKRGVGATSLEKIASYAAINGLSFFQAIQQVDF IGVSAKAANALDSFRQMIENLTNMQDYLSITELTEEILDKTEYREMLKAEKSIEAQSR LENIDEFLSVTKNFEQKSEDKTLVAFLTDLALIADIDQLDQKEEESGGKDAITLMTLH AAKGLEFPVVFLMGLEEGVFPHSRSLMEEAEMEEERRLAYVGITRAEQELYLTNAKMR TLFGRTNMNPESRFIAEIPDDLLENLNEKKETRATSARKMQPRRGPVSRPVSYASKTG GDTLNWAVGDKAGHKKWGTGTVVSVKGEGEGTELDIAFPSPVGVKRLLAAFAPIEKQ* " /label="pcrA CDS" gene 619939..622158 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /label="pcrA gene" CDS 622182..624188 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /EC_number="6.5.1.2" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:164915, 11095673, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 164915, 11095673, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ligase (NAD-dependent)" /protein_id="NP_388544.1" /db_xref="EnsemblGenomes-Gn:BSU06620" /db_xref="EnsemblGenomes-Tr:CAB12482" /db_xref="GOA:O31498" /db_xref="InterPro:IPR001357" /db_xref="InterPro:IPR001679" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004149" /db_xref="InterPro:IPR004150" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013839" /db_xref="InterPro:IPR013840" /db_xref="InterPro:IPR018239" /db_xref="InterPro:IPR033136" /db_xref="InterPro:IPR036420" /db_xref="SubtiList:BG12835" /db_xref="UniProtKB/Swiss-Prot:O31498" /translation="MDKETAKQRAEELRRTINKYSYEYYTLDEPSVPDAEYDRLMQEL IAIEEEHPDLRTPDSPTQRVGGAVLEAFQKVTHGTPMLSLGNAFNADDLRDFDRRVRQ SVGDDVAYNVELKIDGLAVSLRYEDGYFVRGATRGDGTTGEDITENLKTIRNIPLKMN RELSIEVRGEAYMPKRSFEALNEERIKNEEEPFANPRNAAAGSLRQLDPKIAAKRNLD IFVYSIAELDEMGVETQSQGLDFLDELGFKTNQERKKCGSIEEVITLIDELQAKRADL PYEIDGIVIKVDSLDQQEELGFTAKSPRWAIAYKFPAEEVVTKLLDIELNVGRTGVIT PTAILEPVKVAGTTVSRASLHNEDLIKEKDIRILDKVVVKKAGDIIPEVVNVLVDQRT GEEKEFSMPTECPECGSELVRIEGEVALRCINPECPAQIREGLIHFVSRNAMNIDGLG ERVITQLFEENLVRNVADLYKLTKERVIQLERMGEKSTENLISSIQKSKENSLERLLF GLGIRFIGSKAAKTLAMHFESLENLKKASKEELLAVDEIGEKMADAVITYFHKEEMLE LLNELQELGVNTLYKGPKKVKAEDSDSYFAGKTIVLTGKLEELSRNEAKAQIEALGGK LTGSVSKNTDLVIAGEAAGSKLTKAQELNIEVWNEEQLMGELKK*" /label="ligA CDS" gene 622182..624188 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /label="ligA gene" CDS 624204..625394 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388545.1" /db_xref="EnsemblGenomes-Gn:BSU06630" /db_xref="EnsemblGenomes-Tr:CAB12483" /db_xref="GOA:O34629" /db_xref="InterPro:IPR011426" /db_xref="SubtiList:BG12836" /db_xref="UniProtKB/Swiss-Prot:O34629" /translation="MKKTLALAATAAVLMLSACSSGFGGEKEEEITQKTAKSSEKAIV PKYNISDSYYKMVLPFKAGKARGLTTEQLNTRLDIDEFETGLMRLAQDSFSTDDYLFQ EGQYLDEDTVLSWLARKKTGSDLKKAEKEDKNFKNEGLNPALPSSGSTEEKNESSPIY LASMLEHDYLVRKDKNSIQLGGVMIGLALNSVYYYREKTGDPQKEVEIKDSTLRQQGE KIAQEVINRLRKKDNLKNVPITVALYKQASKTSIVPGNFIAKTEVKAGSTDISNWDDI NEKYVFYPADTTTAEKYPDDTEVFKRFKNSIEEYFPNYTGVVGTALYENDEMKKMKID IPMQFYGKSEVVAFTQFLTGEVMDYYSKSSVDVEVNITSSDGQEAVIIRNAGDKEPTV HIYD*" /label="yerH CDS" gene 624204..625394 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /label="yerH gene" misc_feature complement(624399..624403) /Source="Nicolas_upshift_promotors" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(624403) /Source="Nicolas_upshifts" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 625431..625450 /Source="Nicolas_upshift_promotors" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 625439..625555 /Source="Nicolas_S_feature" /locus_tag="new_724870_724986" /HighExp="LoTm, B60, Lbstat, B36, BI, M9-stat, T1.30H, ferm, T3.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S234" upshifts 625439 /Source="Nicolas_upshifts" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(625503) /Source="Nicolas_upshifts" /id="D327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="1.21197" /MaxDrop="3.77048" /score="18.5253059" /energy="-17.7" /TU="NA" /idTUdmin="U511" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" CDS 625556..626566 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase" /protein_id="NP_388546.1" /db_xref="EnsemblGenomes-Gn:BSU06640" /db_xref="EnsemblGenomes-Tr:CAB12484" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG12837" /db_xref="UniProtKB/Swiss-Prot:O34640" /translation="MLDVHKDIKKIFHEEQVLAEAAARYGFSKDQVRFLADAENYVYE CMKDNQPYILKITHTIRRSSDYMMGEMEWLRHLAIGGISVAKPLPSLNGKDVEAVPDG NGGSFLLRVYEKAPGQKVDESDWNETLFYELGRYTGSMHSLTKSYKLSNPAFKRQEWD EEEQLKLRKYVPEDQIKVFQQADSLMNELRRLPKSQDNYGLVHADLHHGNFNWDHGKI TAFDFDDIGYNWFVNDISILLYNVLWYPVVPYDDKAAFTEEFMTHFMKGYWEENELDP AWLMIIPDFLRLRHMLIYGLLHQMFDLNTIGEEEKEMLAGFRRDIENGTPITAFDFSA LV*" /label="yerI CDS" gene 625556..626566 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /label="yerI gene" promotor_no_box complement(625573..625673) /Source="Nicolas_upshift_promotors" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(625613) /Source="Nicolas_upshifts" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 626549 /Source="Nicolas_upshifts" /id="D328" /incds=0 /nref=137 /ntot=253 /MaxReadThrough="3.07041" /MaxDrop="5.10987" /score="12.7441524" /energy="-17" /TU="NA" /idTUdmin="U507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 626593..627397 /Source="Nicolas_S_feature" /locus_tag="new_726024_726828" /HighExp="B60, B36, LoTm, M9-stat, Cold, T1.30H, T0.30H, ferm, Lbstat, LBGstat" /AntisenseName="sapB" /AntisenseCor="-0.57665624439942198" /AntisenseRegPval="-24.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S235" CDS complement(626604..627302) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 410907, 9043134, 14708580, 27350030, 28181542; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative magnesium transporter" /protein_id="NP_388547.1" /db_xref="EnsemblGenomes-Gn:BSU06650" /db_xref="EnsemblGenomes-Tr:CAB12485" /db_xref="GOA:Q45514" /db_xref="InterPro:IPR003416" /db_xref="SubtiList:BG11845" /db_xref="UniProtKB/Swiss-Prot:Q45514" /translation="MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVI AVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGL TTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIR MSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDI KAIEGVVGVKCDTL*" /label="sapB CDS" gene complement(626604..627302) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /label="sapB gene" downshifts complement(626625) /Source="Nicolas_upshifts" /id="D329" /incds=0 /nref=26 /ntot=129 /MaxReadThrough="2.5379" /MaxDrop="3.83708" /score="20.8493264" /energy="-16.2" /TU="NA" /idTUdmin="U511" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(627322..627340) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(627343) /Source="Nicolas_upshifts" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(627356..627361) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(627409..628887) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline transporter" /protein_id="NP_388548.1" /db_xref="EnsemblGenomes-Gn:BSU06660" /db_xref="EnsemblGenomes-Tr:CAB12486" /db_xref="GOA:O06493" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12641" /db_xref="UniProtKB/Swiss-Prot:O06493" /translation="MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFV TALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAA DDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKL GLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEID AVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWM IITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMS SISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTIL DLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVY EIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK*" /label="opuE CDS" gene complement(627409..628887) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /label="opuE gene" downshifts complement(627423) /Source="Nicolas_upshifts" /id="D330" /incds=0 /nref=43 /ntot=142 /MaxReadThrough="5.35634" /MaxDrop="4.34381" /score="9.43100511" /energy="-13.8" /TU="U512,U513" /idTUdmin="U511" /TUdmin="-798" /isTUend="FALSE" /label="downshifts" upshifts complement(628275) /Source="Nicolas_upshifts" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(628278..628291) /Source="Nicolas_upshift_promotors" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(628888..629018) /Source="Nicolas_S_feature" /locus_tag="new_728319_728449_c" /HighExp="Salt, HiOs, Etha, Gly, MG 25, MG 45, M9-exp, MG t5, MG 15, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.954" /TUlongSig="NA" /TUlongPSig="NA" /label="S236" promotor_-10 complement(629009..629027) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(629018) /Source="Nicolas_upshifts" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(629042..629048) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 629149..629152 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 629167..629300 /Source="Nicolas_S_feature" /locus_tag="new_728598_728731" /HighExp="G180, G150, LBGexp, Oxctl, Paraq, dia0, G135, Lbexp, H2O2, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S237" upshifts 629167 /Source="Nicolas_upshifts" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 629169..629188 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 629301..629591 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9342321, 11445070, 12682299, 25005615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9342321, 11445070, 12682299, 25005615; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit C)" /protein_id="NP_388549.1" /db_xref="EnsemblGenomes-Gn:BSU06670" /db_xref="EnsemblGenomes-Tr:CAB12487" /db_xref="GOA:O06492" /db_xref="InterPro:IPR003837" /db_xref="InterPro:IPR036113" /db_xref="SubtiList:BG12838" /db_xref="UniProtKB/Swiss-Prot:O06492" /translation="MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNE VNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD*" /label="gatC CDS" gene 629301..629591 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /label="gatC gene" CDS 629607..631064 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit A)" /protein_id="NP_388550.1" /db_xref="EnsemblGenomes-Gn:BSU06680" /db_xref="EnsemblGenomes-Tr:CAB12488" /db_xref="GOA:O06491" /db_xref="InterPro:IPR000120" /db_xref="InterPro:IPR004412" /db_xref="InterPro:IPR020556" /db_xref="InterPro:IPR023631" /db_xref="InterPro:IPR036928" /db_xref="SubtiList:BG12839" /db_xref="UniProtKB/Swiss-Prot:O06491" /translation="MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFL ALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPI YDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAA AVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITR TVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEA RESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTD NADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDV FEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLP LGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL*" /label="gatA CDS" gene 629607..631064 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /label="gatA gene" CDS 631078..632508 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit B)" /protein_id="NP_388551.2" /db_xref="EnsemblGenomes-Gn:BSU06690" /db_xref="EnsemblGenomes-Tr:CAB12489" /db_xref="GOA:O30509" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR004413" /db_xref="InterPro:IPR006075" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR017958" /db_xref="InterPro:IPR017959" /db_xref="InterPro:IPR018027" /db_xref="InterPro:IPR023168" /db_xref="SubtiList:BG12840" /db_xref="UniProtKB/Swiss-Prot:O30509" /translation="MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGY PGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGEN GWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRT PEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSF AFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDL VELYIDDEWKERVKASIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVQK GAEAKQASNWLMGEVSAYLNAEQKELADVALTPEGLAGMIKLIEKGTISSKIAKKVFK ELIEKGGDAEKIVKEKGLVQISDEGVLLKLVTEALDNNPQSIEDFKNGKDRAIGFLVG QIMKASKGQANPPMVNKILLEEIKKR*" /label="gatB CDS" gene 631078..632508 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /label="gatB gene" downshifts 632489 /Source="Nicolas_upshifts" /id="D331" /incds=0 /nref=257 /ntot=266 /MaxReadThrough="1.62334" /MaxDrop="8.77378" /score="26.1218607" /energy="-9.6" /TU="NA" /idTUdmin="U514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(632523..633392) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388552.1" /db_xref="EnsemblGenomes-Gn:BSU06700" /db_xref="EnsemblGenomes-Tr:CAB12490" /db_xref="GOA:O31500" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG12841" /db_xref="UniProtKB/Swiss-Prot:O31500" /translation="MNEKKERIIKTSIRLFAKKGFAATTIQEIASECGISKGAFYLHF KSKEALLLSACEYYIGMSMNKMKNIEEDLAGKPPKEVLKKQIGAQFEDFRDHKDFIVL LLTENIIPENQEIKQYFYKVTMETDKLYRNALLVSYGEGIERYVADLSIMARGIVHSY MNVMVFNGELNIDAEEISAFIIERLDDLVQGLSRSALNPIVSKDIFNPMPAGKDQLLE DIQKVKENSTLPEDITVSLDVIEEELTQDKPRKPIIKGMLSNLAGTNDKEVERLRALI LSLSQFDHKKSSL*" /label="yerO CDS" gene complement(632523..633392) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /label="yerO gene" downshifts complement(632565) /Source="Nicolas_upshifts" /id="D332" /incds=0 /nref=122 /ntot=211 /MaxReadThrough="2.21801" /MaxDrop="4.89305" /score="32.2694333" /energy="-11.4" /TU="NA" /idTUdmin="U517" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 633182..633187 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-35" promotor_-10 633203..633221 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-10" upshifts 633215 /Source="Nicolas_upshifts" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="upshifts" S_feature complement(633393..633467) /Source="Nicolas_S_feature" /locus_tag="new_732824_732898_c" /HighExp="C30, S1, T3.0H, T4.0H, Salt, T5.0H, T2.0H, T3.30H, MG 150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S238" promotor_-35 633445..633452 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(633461..633480) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 633467 /Source="Nicolas_upshifts" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 633468..633487 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(633474) /Source="Nicolas_upshifts" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(633495..633502) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-35" CDS 633524..636682 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11709341, 15066026, 15941986, 25366377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11709341, 15066026, 15941986, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter involved in surfactin self-resistance" /protein_id="NP_388553.2" /db_xref="EnsemblGenomes-Gn:BSU06710" /db_xref="EnsemblGenomes-Tr:CAB12491" /db_xref="GOA:O31501" /db_xref="InterPro:IPR001036" /db_xref="InterPro:IPR027463" /db_xref="SubtiList:BG12842" /db_xref="UniProtKB/Swiss-Prot:O31501" /translation="MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMP YLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDM DKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSL VSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLY TFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQ VQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVK AELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTL ISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKD EPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAA SLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIA VLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKH VDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQ DFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVA DQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENK KITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKI DKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFS LPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREA LLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLL IVPIVYEVLAKFRKKKPGTEEE*" /label="srfP CDS" gene 633524..636682 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /label="srfP gene" downshifts 636669 /Source="Nicolas_upshifts" /id="D333" /incds=0 /nref=76 /ntot=243 /MaxReadThrough="3.70478" /MaxDrop="4.6624" /score="-3.65521193" /energy="-12.7" /TU="U516" /idTUdmin="U516" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 636921..636924 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 636939..636958 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 636947 /Source="Nicolas_upshifts" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="upshifts" CDS 637005..637916 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /EC_number="2.7.1.107" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12682299, 17535816, 22224599, 24700682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12682299, 17535816, 22224599, 24700682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diacylglycerol kinase" /protein_id="NP_388554.1" /db_xref="EnsemblGenomes-Gn:BSU06720" /db_xref="EnsemblGenomes-Tr:CAB12492" /db_xref="GOA:O31502" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG12843" /db_xref="UniProtKB/Swiss-Prot:O31502" /translation="MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAG DATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALG IPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQL AYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGM FDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGG MLPGEFVNLYRHIHVVMPKEKAEQLDD*" /label="dagK CDS" gene 637005..637916 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /label="dagK gene" S_feature 637917..638171 /Source="Nicolas_S_feature" /locus_tag="new_737348_737602" /HighExp="H2O2, Oxctl, Paraq, G180, Cold, C30, G150, G135, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S239" CDS 638172..639551 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /EC_number="2.1.1.189" /EC_number="2.1.1.190" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21824914" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21824914; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyltransferase of m5U747 and m5U1939 in 23S RNA" /protein_id="NP_388555.1" /db_xref="EnsemblGenomes-Gn:BSU06730" /db_xref="EnsemblGenomes-Tr:CAB12493" /db_xref="GOA:O31503" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12826" /db_xref="UniProtKB/Swiss-Prot:O31503" /translation="MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEE KAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQK QVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDI IDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIV FITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLI GDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAK KVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRK GCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVE CCVLIKLKE*" /label="rlmCD CDS" gene 638172..639551 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /label="rlmCD gene" S_feature 639552..640144 /Source="Nicolas_S_feature" /locus_tag="new_738983_739575" /HighExp="Cold, H2O2, G135, G150, Oxctl, G180, C30, Paraq, LPh, HPh" /AntisenseName="yefB" /AntisenseCor="0.24913678485492899" /AntisenseRegPval="-4.4000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S240" CDS complement(639564..640466) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1779754, 1762151; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase / invertase; HGT island" /protein_id="NP_388556.1" /db_xref="EnsemblGenomes-Gn:BSU06740" /db_xref="EnsemblGenomes-Tr:CAB12494" /db_xref="GOA:O34574" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="SubtiList:BG12827" /db_xref="UniProtKB/Swiss-Prot:O34574" /translation="MYNEGVTSPSQLARKKNATDKWHGSSIRKILENPHYTGTLQQCR EYRPSVTSKRRRSVNLENQIIIEKSHEPIIPLEDFLIVQEILITRKRRRPQAEVHLFT NTAVCKDCRRSMHFKKNRKGYVCGSYNKHGLKACSDHYVSEIDLTDKVITNLNKIYLK FSKENYFKELSEKALKYKEKIESKIIEINEKLNDKKRDKSNLVISLANGVISKEDYQL AINITNEDISNFETTLHQLSKDLEFQKIEKEIIDFKKSLDKFMKEGTLTPEMLHLLVD EIEVHANGTIEINYRFREPTVPSA*" /label="yefB CDS" gene complement(639564..640466) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /label="yefB gene" downshifts 640101 /Source="Nicolas_upshifts" /id="D334" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="4.70474" /MaxDrop="2.82299" /score="-8.81916201" /energy="-8.8" /TU="U518" /idTUdmin="U516" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 640146..640446 /Source="Nicolas_S_feature" /locus_tag="new_739577_739877" /HighExp="H2O2, Cold, G180, G135, G150, Paraq, Oxctl, C30, LPh, LBGexp" /AntisenseName="yefB" /AntisenseCor="0.202214664414261" /AntisenseRegPval="-3.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S241" CDS 640447..640782 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative resolvase; HGT island" /protein_id="NP_388557.2" /db_xref="EnsemblGenomes-Gn:BSU06750" /db_xref="EnsemblGenomes-Tr:CAB12495" /db_xref="GOA:O35034" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG12828" /db_xref="UniProtKB/Swiss-Prot:O35034" /translation="MTPSLYNPLAIASKPFPAIYSEKILIFTIFSAFAEFERDMIVER TQEGKMLAKQNPDFREGRPKKFTKQQINHALTLLENHSYKQVEDMTGISVSTLVRAKK KKAAEAING*" /label="yefC CDS" gene 640447..640782 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /label="yefC gene" S_feature 640783..640856 /Source="Nicolas_S_feature" /locus_tag="new_740214_740287" /HighExp="G180, H2O2, G150, Cold, G135, Paraq, Oxctl, C30, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S242" CDS 640857..643496 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative restriction type II methylase; HGT island" /protein_id="NP_388558.1" /db_xref="EnsemblGenomes-Gn:BSU06760" /db_xref="EnsemblGenomes-Tr:CAB12496" /db_xref="GOA:O31504" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12818" /db_xref="UniProtKB/Swiss-Prot:O31504" /translation="MALIDLEDKIAEIVNREDHSDFLYELLGVYDVPRATITRLKKGN QNLTKRVGEVHLKNKVWFKEAKKGKLFDALIDIEQQVEYLSAKPRYLLVTDYDGVLAK DTKTLEALDVKFEELPQYFDFFLAWKGIEKVEFEKENPADIKAAERFARIYDVLRKEN NIIETNRGLDLFLIRLLFCFFAEDTDIFKRNSFTNLIKTLTEEDGSNLNKLFADLFIV LDKNERDDVPSYLKEFPYVNGQLFTEPHTELEFSAKSRKLIIECGELLNWAKINPDIF GSMIQAVASEESRSYLGMHYTSVPNIMKVIKPLFLDKLNQSFLDAYDDYTKLENLLTR IGKIKFFDPACGSGNFLIITYKELRRMEINIIKRLQELLGEYLYVPSVTLSQFYGIEI EDFAHDVAKLSLWIAEHQMNEELKNEVHNAVRPTLPLHTAGDIRCANAIRVEWTEVCP AQGSEEVYVFGNPPYLGSKKQNKEHKSDMLSIFGKVKNGKMLDYISAWFYFGAKYAST TNAKVAFVSTNSVTQGEQVSILWNELFKFGIQINFAYKSFKWANNAKNNAAVIVVIVG FGPLDTKVNKYLFVDETKKLVSNISPYLTDGENILVSSRTKPISDLPKLHFGNMPNDG GGLLFTITEYTDAINKYPELVPYFKKFIGSVEFINGGLRYCLWLNEAKYEKIKSNPLI QERISISKNHREKSTDKGTNKLALTPWKFRDTHETTNYSIVVPSVSSENRFYIPMGLA GADTILSNLIYVIYDAEIYLLGILMSRMHMTWVKAVAGRLKTDYRYSAGLCYNTFPIP ELSTRRKNEIEEAILEILDLREEQGGTLAELYNPSTMPIELKVAHEKLDGIVERAYRQ KQFESDEERLEVLLKLYQEMTER*" /label="yeeA CDS" gene 640857..643496 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /label="yeeA gene" CDS 643508..645307 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA helicase / endonuclease; HGT island" /protein_id="NP_388559.2" /db_xref="EnsemblGenomes-Gn:BSU06770" /db_xref="EnsemblGenomes-Tr:CAB12497" /db_xref="GOA:O34469" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12819" /db_xref="UniProtKB/Swiss-Prot:O34469" /translation="MENIIEINYNQTGKSKKTNEYGMREMQARAFEKRNSQYLLVKAP PASGKSRALMFIGLDKLINQGLRKVIVAVPERSIGSSFKNTDLKSYGFFENWKVDPRN NLTVGGDNSKVKSFVRFMESDDQVLICTHSTLRFAFEKIDDKAFDNCLLAIDEFHHVS ADVNSRLGELLRSIIHNSSAHIVAMTGSYFRGDSVPILLPEDEELFDKVTYSYYEQLD GYEYLKGFGIGYHFYQGQYTSAINEVLDTNKKTIVHIPNVNSGESTKDKYDEVGKILD MIGEVEYQDDDTGIIYVKRHSDGKTLKIADLVDDQVGRENVVAYLRNIEALDDLDIII ALGMAKEGFDWPFCEHTLTVGYRGSLTEIVQIIGRCTRDSYNKTYAQFTNLIAMPDAK DEVVTYTVNTMLKAISASLLMEQVLTPDFKFKRRRNESEKSSTTGELFVKGLKEPSTE NVKKIIENDINDLKAKIMQDSQVQKTFSGEVDPKVLNKVLIPKVIQKVYPNLSDEEIE EVRQHVVLDTVMKGAKSEVVGSKEFIRMADKFINIEDLDINLIDSINPFQKAFEVLSK ELNSPVLKLIQETIDAKRINFDEDELVFIWPKV*" /label="yeeB CDS" gene 643508..645307 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /label="yeeB gene" promotor_-10 complement(643748..643763) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(643763) /Source="Nicolas_upshifts" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(643775..643784) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 645308..645419 /Source="Nicolas_S_feature" /locus_tag="new_744739_744850" /HighExp="Cold, G180, G135, G150, H2O2, Paraq, HPh, LPh, Oxctl, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S243" CDS 645420..646568 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388560.2" /db_xref="EnsemblGenomes-Gn:BSU06780" /db_xref="EnsemblGenomes-Tr:CAB12498" /db_xref="InterPro:IPR018306" /db_xref="SubtiList:BG12820" /db_xref="UniProtKB/Swiss-Prot:O34352" /translation="MASNRYHSINEIMESQLFYQITTPPKKTQKAQYDPEVEKFLEII EFVKENGREPQKVPTDLTERSLASRLIGIRKDPDRMEYLKEYDEIGLLEVRSKELTIP KISSIDDILKSGLSALLGDNLNNDITRSIFDTSSLQKVTTMPEYVAKRKKIKDFGKFE ELFKKCHKEITEGKRKILTFKNEQDIQSNSFYILKGVLLYVEDVGERKKAKGKTNARL RCIFENGTESDMLLRSLSAELYKHGRRVTDNEDTLLDNVREDDVSTGFIYVLKSLSTD PQISSIKNLYKIGFTTGSVENRIRNAENQSTYLYAPVEIVTTYQVFNMNASKFETAIH HALANNNLDVSILGANGKMLVPKEWFVVTLEDLQAVIDEIVMMVHLYD*" /label="yeeC CDS" gene 645420..646568 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /label="yeeC gene" S_feature 646569..647758 /Source="Nicolas_S_feature" /locus_tag="new_746000_747189" /HighExp="Cold, G135, H2O2, G180, G150, LPh, C30, HPh, BMM, Paraq" /AntisenseName="yeeD" /AntisenseCor="-0.41772847620445203" /AntisenseRegPval="-12.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S244" CDS complement(646830..647135) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388561.1" /db_xref="EnsemblGenomes-Gn:BSU06790" /db_xref="EnsemblGenomes-Tr:CAB12499" /db_xref="SubtiList:BG12821" /db_xref="UniProtKB/Swiss-Prot:O34950" /translation="MTVRKELIKQINLTITVIKTINQKNPTPMVKNILKRYEEAKEFI LQSSDGKFEEDLSKVRNKLDTLTRAYLESANDYMNPMLKEMHKTEKLLKEYDETTQS* " /label="yeeD CDS" gene complement(646830..647135) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /label="yeeD gene" CDS complement(647202..647408) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="hypothetical protein; HGT island" /protein_id="NP_388562.1" /db_xref="EnsemblGenomes-Gn:BSU06800" /db_xref="EnsemblGenomes-Tr:CAB12500" /db_xref="GOA:O31505" /db_xref="InterPro:IPR000290" /db_xref="InterPro:IPR035900" /db_xref="SubtiList:BG12872" /db_xref="UniProtKB/Swiss-Prot:O31505" /translation="MDKLTKEELIFLVKELMNPTLDDEKVSEYLDLLEKNVPYPAPSD LIFWSNEDYTAEQVVKIALNYKDE*" /label="yezA CDS" gene complement(647202..647408) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /label="yezA gene" CDS complement(647648..648103) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="YP_003097692.1" /db_xref="EnsemblGenomes-Gn:BSU06811" /db_xref="EnsemblGenomes-Tr:CAX52579" /db_xref="InterPro:IPR006728" /db_xref="InterPro:IPR036170" /db_xref="UniProtKB/Swiss-Prot:C0H3X4" /translation="MQDLYQLIGEKLNDIIPGEWTKIYLYAEVLDDSTMVLFHFRTPE NNQIIYSQDIPSHYNVSKDIFKTLLRELRELFEELRTEHRNNNDDVWTNLTLTLDRSG EFQLDYNYDDILASELDGYERIAIWEYKNLGILPEDEDDKEFVISYLGL*" /label="yezG CDS" gene complement(647648..648103) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /label="yezG gene" downshifts complement(647661) /Source="Nicolas_upshifts" /id="D335" /incds=0 /nref=41 /ntot=213 /MaxReadThrough="4.42275" /MaxDrop="5.23695" /score="10.2582155" /energy="-11.7" /TU="U520,U521" /idTUdmin="U520" /TUdmin="-529" /isTUend="FALSE" /label="downshifts" CDS complement(648123..650132) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein; HGT island" /protein_id="NP_388563.2" /db_xref="EnsemblGenomes-Gn:BSU06812" /db_xref="EnsemblGenomes-Tr:CAB12501" /db_xref="GOA:O31506" /db_xref="InterPro:IPR006829" /db_xref="SubtiList:BG12822" /db_xref="UniProtKB/Swiss-Prot:O31506" /translation="MKVFEAKTLLSEATDRAKEYKELRTQMVNLRKALKGVADLSDSE FSGKGASNIKAFYHDHVGVADQWIDYIDMKIAFFNSIAGAAEDKGLSDAYIEESFLEH ELANANKKSKSIMSEQKKAMKDILNDIDDILPLDLFSTETFKDELADANDKRKKTLEK LDALDEDLKTEYALSEPNEQFIKSDFQKLQEATGKGKNATPIHYNAKAYRESDIHKKK GDIEKRTEAYLKIKKEEAKEREIEKLKERLKNYDYADADEFYEMAKTIGYENLTAEQQ RYFTQIENTRELEAGFKGVAVGLYDSGKDAVVGLWDMVTDPGGTVEAITGAMAHPIKT YEAISAAIEESYQKDMVNGDTYSRARWVSYAVGTVVTSIVGTKGVGAVSKTGTAAKVT TKVKTAASKSATAQKAITVSKQTVDHIKQKVNTGIEVSKKHVKTKLNQIGDLTLADIL PYHPRHDLVPAGVPYNAVNGVTLKEGLQKFAKVILPKPYGTSSSGRRTPAPHVPPVTV KYGEHFARWSRKKVLKPNIIYKTKEGYTYTTDNYGRITSVKADLQLGEAKRNQYAQTN AGKPQDRKPDDDGGHLIATQFKGSGQFDNIVPMNSQINRSGGKWYEMEQEWAKALSKK PPKKVAVQIEPVYSGDSLRPSYFDVTYKIGSRKEISVSIKNQPGG*" /label="yeeF CDS" gene complement(648123..650132) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /label="yeeF gene" promotor_-10 complement(648490..648509) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(648497) /Source="Nicolas_upshifts" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(648522..648527) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(650159..650178) /Source="Nicolas_upshift_promotors" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(650169) /Source="Nicolas_upshifts" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="upshifts" CDS 650344..651366 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage receptor protein" /protein_id="NP_388564.2" /db_xref="EnsemblGenomes-Gn:BSU06820" /db_xref="EnsemblGenomes-Tr:CAB12502" /db_xref="GOA:O31507" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12823" /db_xref="UniProtKB/Swiss-Prot:O31507" /translation="MTKKRITFGLLVLMVCVILFVLYVQLRNKDSIPVQSSAIHPEED RIFFIYSNPFIKESVLLSTSTGERFNRRTFKVADVPYIQTKSYASTDLVLLAEHEPFY YTLEKDVIKEHPLSDPFAFWYEGKDVTIEAYNVDTTGNEIHINDRKTKKEYTLTLPPL VTMGASDENFIYIIQSMSIYVIDRKTEEMIETLSLASYADQFADSEEFIVASSDHKLT VIEKGTWKTTYIAYPEDLEYADTVYYDKESGSFYVAYEDKEGGANLLEYGEDFSIHTY SLKFPYMEAKFKGNLLYIVAQEEHKKGIGGYVGVFDIHSKEMLYQFDLPEEQVKVQDF VVVDNK*" /label="yeeG CDS" gene 650344..651366 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /label="yeeG gene" promotor_-35 651466..651473 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-35" promotor_-10 651487..651506 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-10" upshifts 651488 /Source="Nicolas_upshifts" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="upshifts" CDS 651528..652658 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388565.2" /db_xref="EnsemblGenomes-Gn:BSU06830" /db_xref="EnsemblGenomes-Tr:CAB12503" /db_xref="GOA:Q59HN8" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG11031" /db_xref="UniProtKB/Swiss-Prot:Q59HN8" /translation="MSQAIPSSRVGVKINEWYKMIRQFSVPDAEILKAEVEQDIQQME EDQDLLIYYSLMCFRHQLMLDYLEPGKTYGNRPTVTELLETIETPQKKLTGLLKYYSL FFRGMYEFDQKEYVEAIGYYREAEKELPFVSDDIEKAEFHFKVAEAYYHMKQTHVSMY HILQALDIYQNHPLYSIRTIQSLFVIAGNYDDFKHYDKALPHLEAALELAMDIQNDRF IAISLLNIANSYDRSGDDQMAVEHFQKAAKVSREKVPDLLPKVLFGLSWTLCKAGQTQ KAFQFIEEGLDHITARSHKFYKELFLFLQAVYKETVDERKIHDLLSYFEKKNLHAYIE ACARSAAAVFESSCHFEQAAAFYRKVLKAQEDILKGECLYAY*" /label="rapH CDS" gene 651528..652658 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /label="rapH gene" CDS 652648..652821 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type r: regulator" /codon_start=1 /transl_table=11 /product="hexapeptide (TDRNTT) inhibitor of regulatory cascade" /protein_id="YP_003097693.1" /db_xref="EnsemblGenomes-Gn:BSU06839" /db_xref="EnsemblGenomes-Tr:CAX52580" /db_xref="GOA:Q59HN7" /db_xref="UniProtKB/Swiss-Prot:Q59HN7" /translation="MPIKKKVMMCLAVTLVFGSMSFPTLTNSGGFKESTDRNTTYIDH SPYKLSDQKKALS*" /label="phrH CDS" gene 652648..652821 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /label="phrH gene" downshifts 652776 /Source="Nicolas_upshifts" /id="D336" /incds=0 /nref=3 /ntot=66 /MaxReadThrough="5.5891" /MaxDrop="2.9063" /score="14.5772672" /energy="-7.6" /TU="U522" /idTUdmin="U522" /TUdmin="-901" /isTUend="FALSE" /label="downshifts" S_feature 652822..652926 /Source="Nicolas_S_feature" /locus_tag="new_752253_752357" /HighExp="S2, G/S, T2.30H, GM 150, T3.0H, T2.0H, S1, T-4.40H, T-2.40H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S245" promotor_-35 652893..652900 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 652915..652934 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 652928 /Source="Nicolas_upshifts" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="upshifts" CDS 652981..653700 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA integrase or transcriptional regulator" /protein_id="NP_388566.3" /db_xref="EnsemblGenomes-Gn:BSU06840" /db_xref="EnsemblGenomes-Tr:CAB12504" /db_xref="GOA:O31509" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026562" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG12824" /db_xref="UniProtKB/Swiss-Prot:O31509" /translation="MGRKWNNIKEKKASKDANTSRIYAKFGREIYVAAKQGEPDPESN QALKVVLERAKTYSVPKNIIERAIEKAKGGAEENYDELRYEGFGPNGSMIIVDALTNN VNRTAPEVRAAFGKNGGNMGVSGSVAYMFDATAVIGVEGKTADEALEILMEADVDVRD ILEEDDSAIVYAEPDQFHAVQEAFKNAGVEEFTVAELTMLAQSEVTLPDDAKEQFEKL IDALEDLEDVQQVYHNVDLGE*" /label="yeeI CDS" gene 652981..653700 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /label="yeeI gene" downshifts complement(652983) /Source="Nicolas_upshifts" /id="D337" /incds=0 /nref=3 /ntot=70 /MaxReadThrough="1.42969" /MaxDrop="3.99424" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-5851" /isTUend="FALSE" /label="downshifts" promotor_-35 653558..653565 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 653579..653598 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 653589 /Source="Nicolas_upshifts" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" downshifts 653682 /Source="Nicolas_upshifts" /id="D338" /incds=0 /nref=223 /ntot=271 /MaxReadThrough="4.94236" /MaxDrop="5.19148" /score="31.0415099" /energy="-11.4" /TU="U523,U524" /idTUdmin="U522" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 653769..653778 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 653792..653811 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 653795 /Source="Nicolas_upshifts" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(653799..653817) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(653819) /Source="Nicolas_upshifts" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(653833..653838) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 653834..654271 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 19060142, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 19060142, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore inner coat protein" /protein_id="NP_388567.2" /db_xref="EnsemblGenomes-Gn:BSU06850" /db_xref="EnsemblGenomes-Tr:CAB12505" /db_xref="GOA:O31510" /db_xref="SubtiList:BG12825" /db_xref="UniProtKB/Swiss-Prot:O31510" /translation="MTDTRHMYGGPGFGHYQGFGIGHPGYGMQSTGYPGYGMYGGHPG YGMQGYPDHGIHGGVGGYPGYGGYGGYPSGGYGGSPGTGSYPSMHHENDGHHHYYHHH HDGKDNLHHHHHHVGKDNHHHHHDGHYGHHHHHMGHWGKDGYK*" /label="cotK CDS" gene 653834..654271 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /label="cotK gene" downshifts complement(653841) /Source="Nicolas_upshifts" /id="D339" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.62645" /MaxDrop="3.26146" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-6709" /isTUend="FALSE" /label="downshifts" downshifts 654271 /Source="Nicolas_upshifts" /id="D340" /incds=0 /nref=82 /ntot=208 /MaxReadThrough="2.37564" /MaxDrop="8.21113" /score="17.7046271" /energy="-9" /TU="U525" /idTUdmin="U523" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 654331..654338 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 654354..654373 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 654359 /Source="Nicolas_upshifts" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="upshifts" CDS 654386..654970 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR family)" /protein_id="YP_054572.1" /db_xref="EnsemblGenomes-Gn:BSU06860" /db_xref="EnsemblGenomes-Tr:CAE01448" /db_xref="GOA:Q7WY76" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14194" /db_xref="UniProtKB/Swiss-Prot:Q7WY76" /translation="MGRNKEFDTALVLHRAIEVFGEYGYEGTSLQDLLSHLGIARQSL YDTYGTKRDLFLSAVKSYLEGKNAAVMERLEAPGSVKEAIRDIFQEGVNALRDPERAK ACYIINSAIEQIPHDPELARYFERQSKQLEDAFYHGLLRAKDQGELNGEDTDISALAR YLNQSRLSLTFIAKVTADMDRLQDHVDVSLSVLD*" /label="yezE CDS" gene 654386..654970 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /label="yezE gene" downshifts 654951 /Source="Nicolas_upshifts" /id="D341" /incds=0 /nref=26 /ntot=216 /MaxReadThrough="2.43615" /MaxDrop="3.31193" /score="17.7046271" /energy="-9" /TU="NA" /idTUdmin="U527" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 655049..655492 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388568.1" /db_xref="EnsemblGenomes-Gn:BSU06870" /db_xref="EnsemblGenomes-Tr:CAB12506" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:1S5A" /db_xref="SubtiList:BG12844" /db_xref="UniProtKB/Swiss-Prot:O31511" /translation="MLMNEFEKACETLRKFMAYMLEKDMKSWTELWDENAVFEFPYAP EGSPKRIEGKAAIYDYIKDYPKQIHLSSFTAPTVYRSADSNTVIAEFQCDGHVIETGL PYRQSYISVIETRDGRIVRYRDYWNPLVVKEAFGGSFLQTEESGK*" /label="yesE CDS" gene 655049..655492 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /label="yesE gene" CDS 655489..656349 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21494745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388569.1" /db_xref="EnsemblGenomes-Gn:BSU06880" /db_xref="EnsemblGenomes-Tr:CAB12507" /db_xref="GOA:O31512" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR008030" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11808" /db_xref="UniProtKB/Swiss-Prot:O31512" /translation="MMKQNPILITGGTGTVGSRIASRLIKLGYRVRIASRKKGALADA EYVYFNWKYASSFTPALEQVKQIYLVAPVGVFDPAPYVLPFLKEAKRLGAKRVVMQSA SVVSENGPVFGALHQAVREFPEWTVLRPSYFMQNFINVQHRMSIQTEGRITTASGEGK LGFIDADDIAETAVRALIDDVPHQTHHILTGPEALSYAEAAEIIGAAAGRRVEHVSIS RSELQHKMEAGGLPADYAHFMAKLDEAISHGAEHRVTDTVKRVTGKEPRSLSEFAAAH AAYWTSFWTE*" /label="yesF CDS" gene 655489..656349 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /label="yesF gene" promotor_-35 656411..656416 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 656432..656450 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 656432 /Source="Nicolas_upshifts" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(656454..656468) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(656459) /Source="Nicolas_upshifts" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(656476..656480) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 656476..656724 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388570.1" /db_xref="EnsemblGenomes-Gn:BSU06890" /db_xref="EnsemblGenomes-Tr:CAB12508" /db_xref="InterPro:IPR020256" /db_xref="SubtiList:BG11799" /db_xref="UniProtKB/Swiss-Prot:Q45536" /translation="MKDMQPFTPVKSYTPFHSRFDPCPPIGKKYYRTPPNLYMTFQPE HMEQFSPMEALRKGTLWKDLYDFYENPYRGGDAHGKKG*" /label="cotJA CDS" gene 656476..656724 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /label="cotJA gene" CDS 656708..656971 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388571.2" /db_xref="EnsemblGenomes-Gn:BSU06900" /db_xref="EnsemblGenomes-Tr:CAB12509" /db_xref="InterPro:IPR016571" /db_xref="InterPro:IPR024207" /db_xref="SubtiList:BG11800" /db_xref="UniProtKB/Swiss-Prot:Q45537" /translation="MAKKVDAEYYRQLEQIQAADFVLVELSLYLNTHPHDEDALKQFN QYSGYSRHLKRQFESSYGPLLQFGNSPAGKDWDWGKGPWPWQV*" /label="cotJB CDS" gene 656708..656971 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /label="cotJB gene" CDS 656986..657555 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /EC_number="1.11.1.6" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7768848, 9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7768848, 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="enzyme component of the inner spore coat" /protein_id="NP_388572.1" /db_xref="EnsemblGenomes-Gn:BSU06910" /db_xref="EnsemblGenomes-Tr:CAB12510" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG11801" /db_xref="UniProtKB/Swiss-Prot:Q45538" /translation="MWVYEKKLQYPVKVSTCNPTLAKYLIEQYGGADGELAAALRYLN QRYTIPDKVIGLLTDIGTEEFAHLEMIATMVYKLTKDATPEQLREAGLGDHYVNHDSA LFYHNAAGVPFTASYIQAKGDPIADLYEDIAAEEKARATYQWLIDISDDPDLNDSLRF LREREIVHSMRFREAVEILKEERDKKKIF*" /label="cotJC CDS" gene 656986..657555 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /label="cotJC gene" S_feature 657556..657634 /Source="Nicolas_S_feature" /locus_tag="new_756987_757065" /HighExp="S4, S5, S3, S7, S6, B36, LoTm, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S246" promotor_-35 657607..657612 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 657627..657646 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 657636 /Source="Nicolas_upshifts" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="upshifts" CDS 657680..658222 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388573.1" /db_xref="EnsemblGenomes-Gn:BSU06920" /db_xref="EnsemblGenomes-Tr:CAB12511" /db_xref="GOA:O31513" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11809" /db_xref="UniProtKB/Swiss-Prot:O31513" /translation="MTAFKIENETIADGFYACPAVYEDAESITGLLVRTAEWLRDRGS NQWSGLLKGQDIHDITGSIEKGHVFVFKKDEELAAVVMLLPAPSEWDRTLWGDDGHEE SIYLHRLAVSRRFAGQGLGARVLQWAETGIHFPEKTRIRLDCVADSDALHSFYRRMGY EFMGADASGYHLFEKEITAE*" /label="yesJ CDS" gene 657680..658222 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /label="yesJ gene" downshifts 658189 /Source="Nicolas_upshifts" /id="D342" /incds=0 /nref=104 /ntot=251 /MaxReadThrough="3.04389" /MaxDrop="4.5316" /score="8.56782582" /energy="-5.8" /TU="U528" /idTUdmin="U530" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS 658245..658547 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388574.2" /db_xref="EnsemblGenomes-Gn:BSU06930" /db_xref="EnsemblGenomes-Tr:CAB12512" /db_xref="GOA:O31514" /db_xref="InterPro:IPR025434" /db_xref="SubtiList:BG12845" /db_xref="UniProtKB/Swiss-Prot:O31514" /translation="MSFSKREAGDVWSILFVTGIVTACLFAGVSVLMRMRFPDKSRPE WMLAGLIVLGVFAIWYSLVYVRGWEGAALGMLGFNVIFGAIAGYLIDKAIRRYRKR*" /label="yesK CDS" gene 658245..658547 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /label="yesK gene" promotor_-35 658590..658598 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 658609..658627 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 658615 /Source="Nicolas_upshifts" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="upshifts" CDS 658662..659291 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25441682; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease or sensor of a three componentsystem for pectin and rhamnogalacturonan transport anddegradation" /protein_id="NP_388575.1" /db_xref="EnsemblGenomes-Gn:BSU06940" /db_xref="EnsemblGenomes-Tr:CAB12513" /db_xref="GOA:O31515" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12846" /db_xref="UniProtKB/Swiss-Prot:O31515" /translation="MLMIHSVANGLNHFCTWVMRLAYLNVLWILFSLAGLVVFGLMPA TAAMFTVAREWAKGNTDAPVFSVFFRTFKKEWRASQILGLIVVTAALFLFADMRIAAQ MDQPVLVNVFVSISLIFAFVVLYVFPVFSHFDVKIREVLSISFFIAFSRPAVTLLMAA GAVGVLCLVLFHVTFLLFFSGSLLSLILTKLSFKAFRSMDQRQEKEKAA*" /label="yesL CDS" gene 658662..659291 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /label="yesL gene" CDS 659288..661021 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 23436677, 25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 23436677, 25441682; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YesN]" /protein_id="NP_388576.1" /db_xref="EnsemblGenomes-Gn:BSU06950" /db_xref="EnsemblGenomes-Tr:CAB12514" /db_xref="GOA:O31516" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12847" /db_xref="UniProtKB/Swiss-Prot:O31516" /translation="MKKRVAGWYRRMKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVY DEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMK QELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRN LWMTLGGSDPVLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMI ADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVI PFDQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIE AGVSLSLPEHTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPH FLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTI QRFRFEERLKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAK GCVCITVEDNGPGMDGRILESTGGRGIGLWNIRERISLTFGEPYGLRIHSEHEKGTRI VITIPCRNEVV*" /label="yesM CDS" gene 659288..661021 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /label="yesM gene" CDS 661021..662127 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25441682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YesM]" /protein_id="NP_388577.1" /db_xref="EnsemblGenomes-Gn:BSU06960" /db_xref="EnsemblGenomes-Tr:CAB12515" /db_xref="GOA:O31517" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12848" /db_xref="UniProtKB/Swiss-Prot:O31517" /translation="MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKI VHKQPHIVITDVKMPGMDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHY LLKPCNEQQIISSLEEIIAELKRQDVHKKKTAHLKHELDHIRSFAADQYLEGLIAGVA QLSPPPSLAGKKIRLLILKGEQSIDAAAREALGSALTAVCSSGEWTVLAVEENAAEKV AEVFADRKMAISQAGELRHAGQLFRDTAEASGDLHGSAVISKMIRLIADELGNPNLSL KWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMKQMKIRRDVSVSEIAEEI GFGDNPKYFSLVFKKYTGLTPSEFRRKQGGASAG*" /label="yesN CDS" gene 661021..662127 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /label="yesN gene" downshifts 662081 /Source="Nicolas_upshifts" /id="D343" /incds=0 /nref=4 /ntot=43 /MaxReadThrough="0.271749999999999" /MaxDrop="3.41261" /score="3.12085441" /energy="-10.3" /TU="NA" /idTUdmin="U531" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" promotor_-35 662166..662169 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 662184..662203 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 662191 /Source="Nicolas_upshifts" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 662231..663514 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 25658435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 25658435; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="pectin degradation byproducts (rhamnose oligosaccharides)-binding lipoprotein" /protein_id="NP_388578.2" /db_xref="EnsemblGenomes-Gn:BSU06970" /db_xref="EnsemblGenomes-Tr:CAB12516" /db_xref="PDB:4R6K" /db_xref="SubtiList:BG12849" /db_xref="UniProtKB/Swiss-Prot:O31518" /translation="MKKICYVLLSLVCVFLFSGCSAGEEASGKKEDVTLRIAWWGGQP RHDYTTKVIELYEKKNPHVHIEAEFANWDDYWKKLAPMSAAGQLPDVIQMDTAYLAQY GKKNQLEDLTPYTKDGTIDVSSIDENMLSGGKIDNKLYGFTLGVNVLSVIANEDLLKK AGVSINQENWTWEDYEKLAYDLQEKAGVYGSNGMHPPDIFFPYYLRTKGERFYKEDGT GLAYQDDQLFVDYFERQLRLVKAKTSPTPDESAQIKGMEDDFIVKGKSAITWNYSNQY LGFARLTDSPLSLYLPPEQMQEKALTLKPSMLFSIPKSSEHKKEAAKFINFFVNNEEA NQLIKGERGVPVSDKVADAIKPKLNEEETNIVEYVETASKNISKADPPEPVGSAEVIK LLKDTSDQILYQKVSPEKAAKTFRKKANEILERNN*" /label="yesO CDS" gene 662231..663514 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /label="yesO gene" CDS 663511..664440 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388579.1" /db_xref="EnsemblGenomes-Gn:BSU06980" /db_xref="EnsemblGenomes-Tr:CAB12517" /db_xref="GOA:O31519" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12850" /db_xref="UniProtKB/Swiss-Prot:O31519" /translation="MTGNGADAMKKSRSIRKDNLAGYAFISPFIIGFLCFTVIPMGAS LFLSFTSYDLFTAPKWIGLDNFKEMFTGDEKYWQSLKVTFTYVLAGVPLRLGFALFIA VILNNAAKGTAIYRTLFYLPSIIGGSVAVAIMWRNIFGNDGVINALLFFVGIDQKILW YQNPTSALWTLILLSVWQFGSSMLIFLAGLKNIPSSYLEAASVDGANRVQRFFKITLP ILTPIIFFNLVMQTISAFMTFTPAYIISKGEGGPLDGTLLYSLYLFQRAFNYFQMGYA SAMAWVMLVIVGLITLILFKTSSYWVHYESKEE*" /label="rhgP CDS" gene 663511..664440 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /label="rhgP gene" CDS 664444..665334 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388580.1" /db_xref="EnsemblGenomes-Gn:BSU06990" /db_xref="EnsemblGenomes-Tr:CAB12518" /db_xref="GOA:O31520" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12851" /db_xref="UniProtKB/Swiss-Prot:O31520" /translation="MEPVNQPVREAPVFERKKAGRVSPKRILFHVFTATLAVLLLYPV IWLFVSSFKESASIFTTSHSLIPDPFILSNYAEGWKGIAGQPFLTFIKNSAIIVGLST IGAVMSSAVIAYGFARIPFKGKKFWFACMMGTLMLPHEVLMIPQYIMFAKLDWLNSFK PIVVPQFFGHAFFIFLMIQFIRTIPEELDEAARIDGCGRFACFWRIILPLIAPALATS AIFSFYWKWEELIQPLLYLNKPELYPVSLALKLFLDTESASNWGAMFAMSAVSLLPVI LVFFLFQKYIVQGISTTGLK*" /label="rhgQ CDS" gene 664444..665334 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /label="rhgQ gene" CDS 665350..666384 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /EC_number="3.2.1.172" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan hydrolase" /protein_id="NP_388581.1" /db_xref="EnsemblGenomes-Gn:BSU07000" /db_xref="EnsemblGenomes-Tr:CAB12519" /db_xref="GOA:O31521" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="SubtiList:BG12852" /db_xref="UniProtKB/Swiss-Prot:O31521" /translation="MAQLIFDEEKVTSVIDRIVKRTFQMDFAWDWPGGVAFYGVAEAY EATENEEYINLLKTWVDEQLEDGLPPLSINGVSIGHTLLFLHKVTGDDVYLETAAEMA EYVLHKAPRFGEGILQHTVNAAEYVFPEQAWADTLMMAGLFMLRIGRVMEREDYFEDG LRQFHGHEDVLQDPVTNLYYHAWDNKAQNHLSGIYWGRANGWAALTMAKALPLIEVTH PSFMIIDGSLRDQLSALVRLQDESGLWHTILDDPDSYLEVSASAGIASALMSSGKLYT KYVQKSLAAILDAVEEDGRVSRVSAGTAVMKNAEGYKQVPYKRIQGWGQGLALTFLAD VLKTKKRLYQ*" /label="rhgH CDS" gene 665350..666384 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /label="rhgH gene" CDS 666407..668692 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19651770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19651770; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AraC/XylS family)" /protein_id="NP_388582.1" /db_xref="EnsemblGenomes-Gn:BSU07010" /db_xref="EnsemblGenomes-Tr:CAB12520" /db_xref="GOA:O31522" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG12853" /db_xref="UniProtKB/Swiss-Prot:O31522" /translation="MKKQPQQKERVSRWKGTYFKRNFVFILLIACIPGLLTGGAIYFL SIDKVEKELQRSHETQVAREVSRMDEKLGVLELALTQMAYDSSLMNGLAERDLEKDFT FSYQLTKKLFLLRDQQPLIEQASIFLNSPRPLVLSPEYSALTEQEALRKYRSLLASDH SIYWKRSGNQAMLIQLIPGAAEKPFGAIMLAVDPKEMESILQSLSPYPDGSALLLDQN REVLFHEGEKDFEKTLLHEIKKQPAENGHFQMEWKGKVYSVSFGEMNRMHQQWTFVSA APLSAITAPMVFLSKVIIVMLVICIGLAVCMTWYASKKIYRPIQHLLGLFTGGEKKTW QASGQDEFKWIEKRWQDLSLESRKLQQQLLRQTPHMKKSFLQHLLQSDFYYDNEESLR FRMEEAGWNIGGNVFHVLDLQVTGLRCEKSIFREGDEQLAVFTLTNIAEELAAKRVFQ LSILDIGRLSVTVLVMKTNSSDLKAYITELARQFGDVTGLCLTSTLSSKTERVTEIPS LFQDVKCGKSRRKFANRDQVIDLQADFPRDEQFAPYYPFELEKQIVQTIRLERKQEAK ELIDGCMKELSEKAAIDRHVHSALIQLFSRIQEDILHSGLNPSELFQHRNPFLDISEL REPNEAAAWLMDVVVTPYLSKLEGRKNRQQKQLAERVIAMIHEQYMADISLESCADAL GMNSYTLSKAFKQVTGINFIDYVTQIRIEKAKELLVNTNKKIHDVSEEVGYRHNYFNR IFKKQVGMPPGVFRQMYQETP*" /label="rhgR CDS" gene 666407..668692 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /label="rhgR gene" CDS 668706..669404 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 17957779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 17957779; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388583.1" /db_xref="EnsemblGenomes-Gn:BSU07020" /db_xref="EnsemblGenomes-Tr:CAB12521" /db_xref="GOA:O31523" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12854" /db_xref="UniProtKB/Swiss-Prot:O31523" /translation="MMKKPIQVFLAGDSTVSDCPPHEAPMAGWGQVFGQLFSEGVLVR NHAKGGASTNSFVEEGRLQAIAEHITQGDYLLIQFGHNDQKPRGTKPYSTFQQFLTLF ADTAREKGAHPVFVTSVQRRRFDENGRIEHTLGEYPDAMKALAKELDVPVIDLLAKTK VLYEAYGPEESKRLFVWFQPNEHPNYPDGIEDNTHFSEKGAMEVAKLVAEGIEELGLP LKDHLVSREGKEHV*" /label="rhgT CDS" gene 668706..669404 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /label="rhgT gene" CDS 669397..670059 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388584.1" /db_xref="EnsemblGenomes-Gn:BSU07030" /db_xref="EnsemblGenomes-Tr:CAB12522" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR015305" /db_xref="PDB:1OQ1" /db_xref="SubtiList:BG12855" /db_xref="UniProtKB/Swiss-Prot:O31524" /translation="MYKEGACLYRNPLRSKSDVKDWRMEGGGQISFDDHSLHLSHVQD EAHFVFWCPETFPDGIIVTWDFSPIEQPGLCMLFFAAAGIRGEDLFDPSLRKRTGTYP EYHSGDINALHLSYFRRKYAEERAFRTCNLRKSRGFHLAAMGADPLPSPDDADSPYRM KLIKDKGYVHFSINGLPILEWMDDGSTYGPVLTKGKIGFRQMAPMKAVYRDFAVHQAV RR*" /label="yesU CDS" gene 669397..670059 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /label="yesU gene" CDS 670056..670682 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane component" /protein_id="NP_388585.1" /db_xref="EnsemblGenomes-Gn:BSU07040" /db_xref="EnsemblGenomes-Tr:CAB12523" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12856" /db_xref="UniProtKB/Swiss-Prot:O31525" /translation="MKTTVTDALYAGCEAVVKIAWLNGLWLLFTLLGGVLFGWAPSTA AMCAVIRKWLMGQKDVPIFSLFLDTYKKEFLKVNAIGLAFSALLLILSANYHYFSAST NWLSFAVTSCTLLAGLLYIIALMYVFPLYVHYQLPLRKYIPQALLFGAMRPLTTGCML IGCGFVLYLLYTLPGLIPFYGPCLFGLVLMFFALRGFQKTEAQHHQAG*" /label="yesV CDS" gene 670056..670682 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /label="yesV gene" CDS 670803..672665 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /EC_number="4.2.2.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan endolyase" /protein_id="NP_388586.1" /db_xref="EnsemblGenomes-Gn:BSU07050" /db_xref="EnsemblGenomes-Tr:CAB12524" /db_xref="GOA:O31526" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2Z8R" /db_xref="PDB:2Z8S" /db_xref="PDB:2ZUX" /db_xref="SubtiList:BG12857" /db_xref="UniProtKB/Swiss-Prot:O31526" /translation="MRRSCLMIRRRKRMFTAVTLLVLLVMGTSVCPVKAEGAARQMEA LNRGLVAVKTDGGIFVSWRFLGTENASVLFNVYRDGQKLNAAPVKTTNYVDKNGSAGS TYTVRAVVNGTEQPASEKASVWAQPYHSVPLDKPAGGTTPKGESYTYSANDASVGDVD GDGQYELILKWDPSNSKDNSQDGYTGDVLIDAYKLDGTKLWRINLGKNIRAGAHYTQF MVYDLDGDGKAEVAMKTADGTKDGTGKVIGNANADYRNEQGRVLSGPEYLTVFQGSTG KELVTANFEPARGNVSDWGDSYGNRVDRFLAGIAYLDGQRPSLIMTRGYYAKTMLVAY NFRDGKLSKLWTLDSSKSGNEAFAGQGNHNLSIADVDGDGKDEIIFGSMAVDHDGKGM YSTGLGHGDALHTGDLDPGRPGLEVFQVHEDKNAKYGLSFRDAATGKILWGVYAGKDV GRGMAADIDPRYPGQEVWANGSLYSAKGVKIGSGVPSSTNFGIWWDGDLLREQLDSNR IDKWDYQNGVSKNMLTASGAAANNGTKATPTLQADLLGDWREEVVWRTEDSSALRIYT TTIPTEHRLYTLMHDPVYRLGIAWQNIAYNQPPHTSFFLGDGMAEQPKPNMYTP*" /label="rhgW CDS" gene 670803..672665 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /label="rhgW gene" promotor_no_box 670843..670943 /Source="Nicolas_upshift_promotors" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 670903 /Source="Nicolas_upshifts" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(671441) /Source="Nicolas_upshifts" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(671442..671461) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(671474..671483) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 672711..674549 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /EC_number="4.2.2.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan exolyase" /protein_id="NP_388587.1" /db_xref="EnsemblGenomes-Gn:BSU07060" /db_xref="EnsemblGenomes-Tr:CAB12525" /db_xref="GOA:O31527" /db_xref="InterPro:IPR013517" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2ZUY" /db_xref="SubtiList:BG12858" /db_xref="UniProtKB/Swiss-Prot:O31527" /translation="MKPKKRQMEYLTRGLIAVQTEQGVFVSWRFLGTDHETTAFHLYR DGKRITRDPIAESTNFLDQNGTADSVYQVAAVNKGREEKLSKKARVWQENVLEVPLAK PEGGVTPDGKPYTYSANDASVGDIDGDGEYEMILKWDPSNSKDNAHDGYTGEVLIDAY KLDGTFLWRINLGRNIRAGAHYTQFMVYDLDGDGKAEIAMKTADGTTDGKGHIIGDEQ ADFRNEQGRILSGPEYLTVFKGETGEALTTVEYEPPRGKLEDWGDGYGNRMDRFLAGT AYLDGERPSLVMARGYYTRTVLVAYDFRNGRLKKRWVFDSNQPGHEAYAGQGNHSLSV ADVDGDGKDEIIYGAMAVDHDGTGLYSTGLGHGDAMHVGDLDPSRKGLEVFQVHEDAT KPYGLSLRDAGTGEILWGVHAGTDVGRGMAAHIDPSYKGSLVWGIDPPGNDGMSYGLF TSKGEKISDKAPSSANFAIWWDGDLVRELLDHDWDGTIGRPKIEKWDAENGCLKTIFQ PAGVLSNNGTKGNPVLQANLFGDWREEVIWRTEDSSALRIYTTTHLTRHCFYTLMHDP VYRLGIAWQNTAYNQPPHTSFYLGTGMKKPPKPALYIAGSKAEAPL*" /label="rhgX CDS" gene 672711..674549 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /label="rhgX gene" CDS 674707..675360 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388588.1" /db_xref="EnsemblGenomes-Gn:BSU07070" /db_xref="EnsemblGenomes-Tr:CAB12526" /db_xref="GOA:O31528" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12859" /db_xref="UniProtKB/Swiss-Prot:O31528" /translation="MANHIYLAGDSTVQTYGDSTNQGGWGQFLGSHLPEHIQVINRAI GGRSSKTFVEEGRLQAILDVIEPDDWLFVQMGHNDASKNKPERYTEPYTTYKQYLKQY IAGAREKGAHPLLITPVARFHYENGVFLNDFPDYCIAMKQTAAEENVQLIDLMEKSLA FFTEKGEEKVYTYFMISEGINDYTHFTKKGANEMAKLVAKGIKELGLPLTESIIKER* " /label="yesY CDS" gene 674707..675360 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /label="yesY gene" CDS 675368..677359 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17056685, 17449691, 17485082" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17056685, 17449691, 17485082; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-galacturonidase" /protein_id="NP_388589.1" /db_xref="EnsemblGenomes-Gn:BSU07080" /db_xref="EnsemblGenomes-Tr:CAB12527" /db_xref="GOA:O31529" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12860" /db_xref="UniProtKB/Swiss-Prot:O31529" /translation="MRKLYHGACYYPELWDEETIQQDIDIMREVGVNVVRIGEFAWSV MEPEEGKIDVGFFKEIIARLYDSGIETIMCTPTPTPPIWFSHGRPERMHANEKREIMG HGSRQHACTNNPYFRKKAAIITTAIAKELGRLPGLIGWQLDNEFKCHVAECMCETCLR LWHDWLKNRYGVIERLNEAWGTDVWSETYQTFEQVPQPGPAPFLHHASLRTMYQLFSM EMIASFADEQAKIIRCYSDAPITHNGSVMFSVDNERMFQNLDFASYDTYASQENASAF LLNCDLWRNLKQGRPFWILETSPSYAASLESSAYPHADGYLQAEAVSSYALGSQGFCY WLWRQQRSGSEISHGSVLSAWGEPTIGYQNVLAVERARKEIEPIILSTEPVQAEAAMT YSDRAKAFIKTEPHRGLRHRSLVTHFYERILNTGIHRDLIPEGAPLDGYRLLFTPFVP YLSSEFIKKASAFAEAGGIWITGPLTGGRTCEHTIHTDCGLGELEKTSGIKTLFTFPM NENVNTGKAFGITAPLGLWSAVFDTESGNTLGTVEAGPGAGHAFLTERNYGEGKIVML GSLPSGKEGDAMLEALVRHYAEEAVISSRSDVTPGTIVAPRIGENGLVWIVVNMDGKG GSVTLPESGTDLLTHRLEKAGRLAVGPHEYRVIQFDNHS*" /label="rhgZ CDS" gene 675368..677359 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /label="rhgZ gene" CDS 677403..679976 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388590.2" /db_xref="EnsemblGenomes-Gn:BSU07090" /db_xref="EnsemblGenomes-Tr:CAB12528" /db_xref="SubtiList:BG12861" /db_xref="UniProtKB/Swiss-Prot:O31530" /translation="MKKIKWLSGQPKVTSGVTWGMPWKKGELKKGDRLALMNENAETR YVQSEPSAYWPDGSIKWTKHAAVFGGQENQSFTVHKREVPQPTESLSILETEHDIQVD TGALVCTIHKTGSDFIQSLQINGKPIAAGGRLVAIRETRKESAAKMVLLHERSVSFIK RAAIEQSGPVKAVVKIEGVHVLHKTYEEWLPFVIRLTFYAGLSEIGLVHTQLIDRSGK LEFVKGLGIEFDLFLEGEPYNRHFRFAGEKGMYKEPAQLFGTRKFNERYPLYEKQING EMLSPDEEHKEWFAHGTQNAVWDDVKIVQDSSDHYSLSKRTGKDYAWVGMLHGSRAKG LCYAGGKNGGVALGLRYFFEKYPSALEITGLAGSRPKMTIWLWPPDGEAMDLRHYTGN THVASAYEGFDEMRSDPTGIANTNEISLACFSHMPSDEVLNALADKWQAPPLIVCEPD VYYESKALGVWSIIDTSHPLKKELEEQLDAAFLFYKKEVEQRRWYGFWHYGDVMHTYD PIRHMWRYDLGGYAWQNNELVPTLWLWQAFFRSGREDIFRMAEAMTRHTSETDSFHLG EYAGLGSRHNVVHWGCGCKEARISMAGLHKFYYYLTGDDRTGDLLTEVKDADYALVKT DPMRAFYEKGKHPTHARTGPDWAAFCSNWLAEWERTENSEYLKKIETGINCLKRLPLR LLSGPTFEYDPATSMLHHMGDGIAGGYHMIIAFGAPQVWMELAELLDDWEWEDMLSEF GEFYTLSDEEKRKKSGGALHDGHFHWPMFAAGMTAYAARKKQDPHLAAKAWNLLLEDK LSHTPLPIKPERIETWTQLEELPWVTTNTVSQWCLNVIAALELIGDSLPAKKETSGKK G*" /label="yetA CDS" gene 677403..679976 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /label="yetA gene" promotor_-10 complement(678725..678743) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(678738) /Source="Nicolas_upshifts" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(678759..678764) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 680098..681606 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921237; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein transporter binding protein for alpha-galacturonides" /protein_id="NP_388591.1" /db_xref="EnsemblGenomes-Gn:BSU07100" /db_xref="EnsemblGenomes-Tr:CAB12529" /db_xref="GOA:P37966" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG10434" /db_xref="UniProtKB/Swiss-Prot:P37966" /translation="MKIRMRKKWMALPLAAMMIAGCSHSETSNSASGSKDTIKIMAPL LSPESPSDKSPSLKALEKYTGKEIKVTWVPDSSYNDKFNIVMASGEMPHAIVIKDKSA GFIKSVKAGAFWELSPYLKDYKNLSQADEKILKNSSVNGEVYGIYRTRDLIRACMIIR TDWLKNVGLDMPETLDDFYEVLKAFKEKDPDGNGKDDTYGMVVPKWMGLGNGSPWDVL QIWFGAPNRYGVENGKLIPDFTTKEYMDALTFFKKLYDEGLINKDFAVMDSAKWNDPV VKGKAGVIVDTGSRASQIQSAMEEADESNKDIIDIVGSLEGPNGKRTFPTSGYSGMIT IPKSSVKTEKELKEVLSFLDKMNDKEAQILTNNGVKGRNYELKDGVFTSLEKNNKSLL YEHEGLAQFSMSIPKSEYYIEDQKTKLFQHRKDIITEGEKIAVFNPAESLVSDVYTQK GAQLDNIILDARTQFIIGEIDEKGFDDAVELWKKSGGNELMKDLNKLYQSSK*" /label="lplA CDS" gene 680098..681606 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /label="lplA gene" CDS 681661..682617 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388592.1" /db_xref="EnsemblGenomes-Gn:BSU07110" /db_xref="EnsemblGenomes-Tr:CAB12530" /db_xref="GOA:P39128" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10435" /db_xref="UniProtKB/Swiss-Prot:P39128" /translation="METVPKKRDAPVLTAGKGISWMAALKRDKWLYLLLIPGLLYFLI FKYLPMWGVLIAFKDYSPYLGFWKSEWVGFDYFKDFFMNPDFFRLLRNTLMLASLDLL FAFPAPLILALLLNEVRKAVYKRCIQTFIYVPHFVSWTIVVSITFVFFTVDTGVINKL IMSLTGEQISFLSDADWFRPMIVMQSIWKETGWGTILFLAALATVDQEQYEAAIMDGA GRFRRMWHITLPAIRSTIIVLLILRIGSFLNLGFEQVYLMTNSLNRSVADIFDTYVYM MGITQGAYSYSTAVGLFKSVVGIILIFGANYIAKKFDQEGLF*" /label="lplB CDS" gene 681661..682617 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /label="lplB gene" downshifts complement(681935) /Source="Nicolas_upshifts" /id="D344" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="1.59638" /MaxDrop="4.19822" /score="13.9744253" /energy="-20.3" /TU="NA" /idTUdmin="U538" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(681961..682061) /Source="Nicolas_upshift_promotors" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(682001) /Source="Nicolas_upshifts" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 682631..683518 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388593.1" /db_xref="EnsemblGenomes-Gn:BSU07120" /db_xref="EnsemblGenomes-Tr:CAB12531" /db_xref="GOA:P39129" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10857" /db_xref="UniProtKB/Swiss-Prot:P39129" /translation="MAEIHTMHNTKAGRVFDVCNILFLGGVGAITILPFLYIIAGSFA TEAELAQRSFFIFPKTFTLDAYKYVFSTPTFLRSMGVSIFITVVGTAVQLFFTFTMAY PLAKRHVKGRNLLLNLVIFSMLFSGGMIPTYLVVKSLGLLDTYWALILPMAINPFNLI IIKNFFQQLPRELEESAKIDGCSEIGVFWRIALPLSKPVIATFALFYAVGIWNDFFHA LLYINDSAKWPLQMVLRQVTILSDLTATNGDTMQNAVPPEQGIKLAVIVIATLPILAV YPFLQKHFAKGMLIGSVKG*" /label="lplC CDS" gene 682631..683518 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /label="lplC gene" promotor_-35 683265..683270 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 683286..683304 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 683289 /Source="Nicolas_upshifts" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="upshifts" CDS 683527..684867 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23416295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23416295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-galacturonidase" /protein_id="NP_388594.1" /db_xref="EnsemblGenomes-Gn:BSU07130" /db_xref="EnsemblGenomes-Tr:CAB12532" /db_xref="GOA:P39130" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:3FEF" /db_xref="SubtiList:BG10858" /db_xref="UniProtKB/Swiss-Prot:P39130" /translation="MFHISTLDQIKIAYIGGGSQGWARSLMSDLSIDERMSGTVALYD LDFEAAQKNEVIGNHSGNGRWRYEAVSTLKKALSAADIVIISILPGSLDDMEVDVHLP ERCGIYQSVGDTVGPGGIIRGLRAVPIFAEIARAIRDYAPESWVINYTNPMSVCTRVL YKVFPGIKAIGCCHEVFGTQKLLAEMVTERLGIEVPRREDIRVNVLGINHFTWITKAS YRHIDLLPIFREFSAHYGESGYELEGECWRDSVFCSAHRVAFDLFETYGAIPAAGDRH LAEFLPGPYLKQPEVWKFHLTPISFRKQDRAEKRQETERLIVQQRGVAEKASGEEGVN IIAALLGLGELVTNVNMPNQGQVLNLPIQAIVETNAFITRNRVQPILSGALPKGVEML AARHISNQEAVADAGLTKDTGLAFQAFLNDPLVQIDRSDAEQLFNDMLQCIMQS*" /label="lplD CDS" gene 683527..684867 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /label="lplD gene" S_feature complement(683961..685652) /Source="Nicolas_S_feature" /locus_tag="new_783392_785083_c" /HighExp="H2O2, dia15, Paraq, Lbexp, LBGexp, Salt, LPhT, GM 25, G150, dia0" /AntisenseName="yetF" /AntisenseCor="-0.25986434675098202" /AntisenseRegPval="-4.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S247" S_feature 684868..684949 /Source="Nicolas_S_feature" /locus_tag="new_784299_784380" /HighExp="S5, S4, S6, S3, S7, S8, BT, LoTm, B36, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S248" CDS 684950..685645 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388595.1" /db_xref="EnsemblGenomes-Gn:BSU07140" /db_xref="EnsemblGenomes-Tr:CAB12533" /db_xref="GOA:O31533" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="PDB:3C6F" /db_xref="SubtiList:BG12862" /db_xref="UniProtKB/Swiss-Prot:O31533" /translation="MGNYLSVAVELVCGLGILFIILKLLGKTQFSQITPFDFISALIL GELVGNAVYDHEIKIKEIIFASLLWGVLIYIIEFITQKMKSSRKFLEGEPNIVIRKGE LQYKVMKKNKIDINQLQSLLRQAGSFSIQEVEYAILETNGMVSVLPKSDFDKPTNKDL QIPSKSVSLPITLIIDGEIVRDNLKEAGVDEQWLKQELKKKNIDKTEDVLFAEWHKNK PLYTVTYEQSRST*" /label="yetF CDS" gene 684950..685645 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /label="yetF gene" downshifts 685643 /Source="Nicolas_upshifts" /id="D345" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.32891" /MaxDrop="3.45213" /score="-0.176154378" /energy="-7.1" /TU="NA" /idTUdmin="U537" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(685682..686008) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /EC_number="1.14.14.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20180905, 21764939, 21873409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20180905, 21764939, 21873409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388596.2" /db_xref="EnsemblGenomes-Gn:BSU07150" /db_xref="EnsemblGenomes-Tr:CAB12534" /db_xref="GOA:O31534" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12863" /db_xref="UniProtKB/Swiss-Prot:O31534" /translation="MFVQLRKMTVKEGFADKVIERFSAEGIIEKQEGLIDVTVLEKNV RRGDEEVVVMIRWESEDHWKQWEKSDAHIAGHKANKGKPKPDYLISTEVSMYHVRAVK QGTYNQ*" /label="hmoA CDS" gene complement(685682..686008) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /label="hmoA gene" downshifts complement(685697) /Source="Nicolas_upshifts" /id="D346" /incds=0 /nref=194 /ntot=248 /MaxReadThrough="4.01189" /MaxDrop="6.29183" /score="9.23596913" /energy="-9.1" /TU="U538" /idTUdmin="U539" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 685995 /Source="Nicolas_upshifts" /id="D347" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.96802" /MaxDrop="3.46057" /score="-7.34187128" /energy="-5" /TU="NA" /idTUdmin="U537" /TUdmin=352 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(686031..686050) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(686049) /Source="Nicolas_upshifts" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(686065..686072) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(686112..686474) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase/dioxygenase" /protein_id="NP_388597.1" /db_xref="EnsemblGenomes-Gn:BSU07160" /db_xref="EnsemblGenomes-Tr:CAB12535" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12864" /db_xref="UniProtKB/Swiss-Prot:O31535" /translation="MIKQIGTVAVYVEDQQKAKQFWTEKVGFDIAADHPMGPEASWLE VAPKGAETRLVIYPKAMMKGSEQMKASIVFECEDIFGTYEKMKTNGVEFLGEPNQMEW GTFVQFKDEDGNVFLLKE*" /label="yetH CDS" gene complement(686112..686474) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /label="yetH gene" promotor_-10 complement(686497..686516) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-10" upshifts complement(686511) /Source="Nicolas_upshifts" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="upshifts" promotor_-35 complement(686529..686535) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-35" S_feature complement(686545..687105) /Source="Nicolas_S_feature" /locus_tag="new_785976_786536_c" /HighExp="S8, S6, S7, S5, BT, B36, G/S, B60, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S249" downshifts complement(686577) /Source="Nicolas_upshifts" /id="D348" /incds=0 /nref=38 /ntot=47 /MaxReadThrough="0.395850000000001" /MaxDrop="8.2984" /score="45.4672528" /energy="-13.7" /TU="NA" /idTUdmin="U540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(687088..687107) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(687105) /Source="Nicolas_upshifts" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(687121..687130) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 687193..687200 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 687209 /Source="Nicolas_upshifts" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 687213..687232 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 687258..687839 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; N-terminal part of YetI" /db_xref="SubtiList:BG12865" /translation="MNIDQLLYQYIIDNTADITEKWFSLRCQLKGELYSASHLSEETK TLLTEQHTFTNITIASAFLEDQTDFQENMTKWAQNVAKNRVEQDVQVHEVVEAISNSR ISFWDAVATFIKENQEIVTNEDADRWNRIVNQSFDKLIIEFSEQYQKFMLMRLTSQQE LISELGCPVISIADGIGILPLIGSIDTKRHRSF*" /label="yetI CDS" gene 687258..687839 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /pseudo /label="yetI gene" CDS 687833..688129 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; C-terminal part of YetI" /db_xref="GOA:O31537" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="PSEUDO:CAB12537.2" /db_xref="SubtiList:BG12873" /db_xref="UniProtKB/Swiss-Prot:O31537" /translation="MLETVPVRCVERKITSLVVDLSGVPIVDTMVAQQLYNLSKTLFL LGVKAVFSGIRPDVAQTSIQLGLDFSEYETYGTLKQALENMGVRCIVEELEENK*" /label="yetI CDS" gene 687833..688129 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /pseudo /label="yetI gene" downshifts 688121 /Source="Nicolas_upshifts" /id="D349" /incds=0 /nref=114 /ntot=215 /MaxReadThrough="1.06939" /MaxDrop="4.8053" /score="16.356572" /energy="-21.2" /TU="NA" /idTUdmin="U541" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 688200..688207 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 688221..688240 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 688229 /Source="Nicolas_upshifts" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 688284..688451 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388600.1" /db_xref="EnsemblGenomes-Gn:BSU07190" /db_xref="EnsemblGenomes-Tr:CAB12538" /db_xref="InterPro:IPR018743" /db_xref="SubtiList:BG12875" /db_xref="UniProtKB/Swiss-Prot:O31538" /translation="MVSKSTIDPEVIEKIISSLETLDFGTVQITVHDSQITQIEKIEK HRFSLKRKESK*" /label="yezD CDS" gene 688284..688451 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /label="yezD gene" promotor_-35 688493..688500 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 688516..688535 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 688517 /Source="Nicolas_upshifts" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 688561..689205 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /function="7.4: Cations and iron carrying compounds" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 16086852, 24904158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 16086852, 24904158; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pH-sensitive calcium-leak permease (di-aspartyl pH sensor)" /protein_id="NP_388601.1" /db_xref="EnsemblGenomes-Gn:BSU07200" /db_xref="EnsemblGenomes-Tr:CAB12539" /db_xref="GOA:O31539" /db_xref="InterPro:IPR006214" /db_xref="PDB:4PGR" /db_xref="PDB:4PGS" /db_xref="PDB:4PGU" /db_xref="PDB:4PGV" /db_xref="PDB:4PGW" /db_xref="PDB:4TKQ" /db_xref="SubtiList:BG12866" /db_xref="UniProtKB/Swiss-Prot:O31539" /translation="MQATVHESKQSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLP LSILEVAMIILAFWMRRRKAVGYAFVYTFAFVSGITLFPIVSHYASIAGAYVVLEAFG STFVIFAVLGTIGAKMKKDLSFLWSFLLVAVLALAVVGIFNIFSPLNSAAMMAYSVIG TIVFSLYILYDLNQIKHRHITEDLIPVMALSLYLDFINLFINLLRFFGILSSDD*" /label="calJ CDS" gene 688561..689205 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /label="calJ gene" downshifts 689141 /Source="Nicolas_upshifts" /id="D350" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="6.69003" /MaxDrop="2.5446" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U541" /TUdmin=1012 /isTUend="FALSE" /label="downshifts" downshifts 689185 /Source="Nicolas_upshifts" /id="D351" /incds=0 /nref=7 /ntot=127 /MaxReadThrough="5.33515" /MaxDrop="3.71552" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" CDS 689205..690197 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388602.1" /db_xref="EnsemblGenomes-Gn:BSU07210" /db_xref="EnsemblGenomes-Tr:CAB12540" /db_xref="GOA:O31540" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12867" /db_xref="UniProtKB/Swiss-Prot:O31540" /translation="MKKRLSLDRRFLPYIKKAGGVLVKKQMGAYVSLAAAMAIVGSSV VVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFPALTKKDVFVLLVQSFTGVF LFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKIEKKTLIGILLAVCGVMA INLFGAGSQDGTPHALFGNMLIIAAVIGEALFTLMAKLLSPHISALAISTFVSLFGFL FFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAFYLWYSGVTKVPAGVSGIFTS VLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKKQPDAYPAAEEKTL*" /label="yetK CDS" gene 689205..690197 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /label="yetK gene" downshifts 690131 /Source="Nicolas_upshifts" /id="D352" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="4.14475" /MaxDrop="2.73453" /score="21.8095329" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 690175 /Source="Nicolas_upshifts" /id="D353" /incds=0 /nref=94 /ntot=214 /MaxReadThrough="0.120229999999999" /MaxDrop="4.45909" /score="21.8095329" /energy="-10.7" /TU="NA" /idTUdmin="U542" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(690221..690724) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19329649, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19329649, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (FlvL-flavonoids)" /protein_id="NP_388603.1" /db_xref="EnsemblGenomes-Gn:BSU07220" /db_xref="EnsemblGenomes-Tr:CAB12541" /db_xref="GOA:O31541" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12868" /db_xref="UniProtKB/Swiss-Prot:O31541" /translation="MELKHLPKYKHITEHAETYANIDAGSLELFLSLFDISKKMNHVM EHYFAGRGLSEGKFKILMLLFDAKDHRLSPTELAKRSNVTKATITGLLDGLARDGFVS RRHHTEDKRKISIELTTEGKARLEQFLPGHFSKISAVMENYSDEEKDMFVKMLGDLFE RLSVFKD*" /label="flvL CDS" gene complement(690221..690724) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /label="flvL gene" promotor_-10 complement(690749..690768) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(690757) /Source="Nicolas_upshifts" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(690782..690789) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 690887..691996 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25209494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-dependent hydroxylase/monooxygenase acting on salicylate derivatives" /protein_id="NP_388604.1" /db_xref="EnsemblGenomes-Gn:BSU07230" /db_xref="EnsemblGenomes-Tr:CAB12542" /db_xref="GOA:O06489" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12869" /db_xref="UniProtKB/Swiss-Prot:O06489" /translation="MKHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGIL QPQNALAVLKELGVFEDCCKHGFQTEWFKTFDEQGNLLFQVSESFLDDSLPGRNNILR KTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILAGFDGIHSV VRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVF VLQPCTSDYWDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWH KGRVIIGGDAAHAGAPTLAQGAAMAIEDAIVLAEELQNHADHETALQAYYKRRAPRAL KVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY*" /label="flvM CDS" gene 690887..691996 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /label="flvM gene" downshifts 691979 /Source="Nicolas_upshifts" /id="D354" /incds=0 /nref=7 /ntot=67 /MaxReadThrough="0.0953400000000002" /MaxDrop="5.1482" /score="13.261567" /energy="-12.6" /TU="NA" /idTUdmin="U542" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS complement(692031..693101) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388605.1" /db_xref="EnsemblGenomes-Gn:BSU07240" /db_xref="EnsemblGenomes-Tr:CAB12543" /db_xref="InterPro:IPR025006" /db_xref="InterPro:IPR025012" /db_xref="SubtiList:BG12870" /db_xref="UniProtKB/Swiss-Prot:O06490" /translation="MDFEIRFLSFYVIQVEGKDEQANKQFKHFQTLDTGEFEESELKD FLDGELKKIVKRKADRHPQSEQVPTKIGHFIVEPGHELDSNPNYNMFNRARLAETKED FNELSEQFVRTYLDTSAVRGGVFLVASAVPRKYFDESFVFIMKCDFEPKVARISDASS LIKKVEMAITTKNMKSIQYPYMPEEGMVEEGELKIHQASHARYFEDFLKFVEYGESMP EIMKNQVMNMVQEHVYETFEDNSEELKQFEHDIEIWEASEKREIQERLDTHQVIEASA QIIEHTPEAQLKMKVGETEIKGLLADFGDSIHLAKVNGRYVALIEAETISFEKGSSPV EFYKPEGLHEVIERIRNKTEQD*" /label="yetN CDS" gene complement(692031..693101) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /label="yetN gene" downshifts complement(692055) /Source="Nicolas_upshifts" /id="D355" /incds=0 /nref=45 /ntot=180 /MaxReadThrough="0.83729" /MaxDrop="4.28938" /score="0.323038441" /energy="-11.6" /TU="NA" /idTUdmin="U545" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(693132..693151) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(693158) /Source="Nicolas_upshifts" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(693166..693173) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 693181..693187 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 693202..693220 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 693211 /Source="Nicolas_upshifts" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="upshifts" CDS 693251..696436 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /EC_number="1.6.2.4" /EC_number="1.14.14.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11574077, 2544578, 21048857, 26452461; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional P-450/NADPH-P450 reductase 1" /protein_id="NP_388606.1" /db_xref="EnsemblGenomes-Gn:BSU07250" /db_xref="EnsemblGenomes-Tr:CAB12544" /db_xref="GOA:O08394" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12871" /db_xref="UniProtKB/Swiss-Prot:O08394" /translation="MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS VQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVA RELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIK PGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQL DEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENR ELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTL SASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSA EGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQAS ITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMV GPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTV HTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQ AVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI*" /label="cypD CDS" gene 693251..696436 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /label="cypD gene" downshifts 696423 /Source="Nicolas_upshifts" /id="D356" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.31156" /MaxDrop="2.91666" /score="9.17315362" /energy="-9.8" /TU="NA" /idTUdmin="U546" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 696486..696491 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 696507..696525 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 696528 /Source="Nicolas_upshifts" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 696556..696559 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 696576..696595 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 696577..696882 /Source="Nicolas_S_feature" /locus_tag="new_796008_796313" /HighExp="H2O2, Paraq, Oxctl, Cold, Heat, LBGexp, G180, G150, HPh, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.841" /TUlongSig="NA" /TUlongPSig="NA" /label="S250" upshifts 696577 /Source="Nicolas_upshifts" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" CDS 696883..698802 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11544192, 15187182, 17434969, 17483484, 21255105, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="exported glycerol phosphate lipoteichoic acid synthetase and anion-binding protein" /protein_id="NP_388607.2" /db_xref="EnsemblGenomes-Gn:BSU07260" /db_xref="EnsemblGenomes-Tr:CAB12545" /db_xref="GOA:Q797B3" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG12980" /db_xref="UniProtKB/Swiss-Prot:Q797B3" /translation="MKKLFSYKLSFFVLAVILFWAKTYLSYKTEFNLGVKGTTQEILL IFNPFSSAVFFLGLALLAKGRKSAIIMLIIDFLMTFVLYANILFYRFFDDFLTFPNIK QSGNVGNMGDGIFSIMAGHDIFYFLDIIILIAVLIWRPELKEYKMKKRFASLVILSGI ALFFINLHYAEKDRPQLLTRTFDRNYIVKYLGLYNYTIYDGVQTAQTETQRAYASSDD LTSVENYTTSHYAKPNAEYFGSAKGKNIIKIHLESFQSFLIDYKLNGEEVTPFLNKLA HGGEDVTYFDNFFHQTGQGKTSDAELTMDNSIFGLPEGSAFVTKGENTYQSLPAILDQ KEGYTSAVLHGDYKSFWNRDQIYKHIGYDKFFDASTYDMSDENVINMGLKDKPFFTES IPKLESLKQPFYAHLITLTNHYPFNLDEKDASLKKATTGDNTVDSYFQTARYLDEALE QFFKELKEAGLYDNSVIMIYGDHNGISENHNRAMKEILGKEITDYQNAQNQRVPLMIR VPGKKGGVNHTYGGEIDVMPTLLHLEGIDSQKYINFGTDLFSKDHDDTVAFRNGDFVT PKYTSVDNIIYDTKTGEKLKANEETKNLKTRVNQQLSLSDSVLYKDLLRFHKLNDFKA VDPSDYHYGKEKEIK*" /label="ltaSA CDS" gene 696883..698802 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /label="ltaSA gene" downshifts 698801 /Source="Nicolas_upshifts" /id="D357" /incds=0 /nref=103 /ntot=261 /MaxReadThrough="1.69168" /MaxDrop="7.8227" /score="37.7648461" /energy="-24" /TU="NA" /idTUdmin="U547" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 698890..698899 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 698909..699037 /Source="Nicolas_S_feature" /locus_tag="new_798340_798468" /HighExp="BT, B36, S8, S7, G/S, Pyr, B60, S6, Glucon, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S251" upshifts 698909 /Source="Nicolas_upshifts" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 698913..698932 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(698963) /Source="Nicolas_upshifts" /id="D358" /incds=0 /nref=2 /ntot=6 /MaxReadThrough="1.80969" /MaxDrop="4.63324" /score="20.6569889" /energy="-23.4" /TU="NA" /idTUdmin="U552" /TUdmin=4928 /isTUend="FALSE" /label="downshifts" CDS 699038..699802 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /EC_number="2.7.7.33" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15634670, 16357223, 26577401" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15634670, 16357223, 26577401; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase (sporulation)" /protein_id="NP_388608.1" /db_xref="EnsemblGenomes-Gn:BSU07270" /db_xref="EnsemblGenomes-Tr:CAB12546" /db_xref="GOA:O06486" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR013446" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12979" /db_xref="UniProtKB/Swiss-Prot:O06486" /translation="MKAVILCGGKGTRMSEVTNDIPKPLAMIGGKPILWHIMKIYQYY GVNEFILLLGYKGEKIKEYFLDYEWKHNSLTLDSSTGEVQMLGQPETWKITFLETGVD TLTAGRILQAKDYIGDETFLLTYGDGLANINLFHLISYHQTKGAAATVTGIDKVSQFG TLTVEDGMAKTFSEKTSSDGIINGGFFVLSPKVFDYLPKDGNTMFEDEPLKNLAKDGE LAVYRHYGFWTAIDTYKNLLEVNKMWNQGQQVWKVW*" /label="spmH CDS" gene 699038..699802 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /label="spmH gene" CDS 699809..700777 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CDP-sugar-dehydratase/epimerase" /protein_id="NP_388609.2" /db_xref="EnsemblGenomes-Gn:BSU07280" /db_xref="EnsemblGenomes-Tr:CAB12547" /db_xref="GOA:O06485" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12978" /db_xref="UniProtKB/Swiss-Prot:O06485" /translation="MSFWKNKNVFVTGCTGLLGSYLVKELIEQGANVTGLVRDHVPQS NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEIDTVFHLAAQAIVGVANRNPISTFEA NILGTWNILEACRKHPLIKRVIVASSDKAYGDQENLPYDENMPLQGKHPYDVSKSCAD LISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQTIQLVLNGEAPEIRSDGTFVRD YFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVLELVEKILKKMNSNLKPKVL NQGSNEIKHQYLSAEKARKLLNWTPAYTIDEGLEKTIEWYTEFFKK*" /label="spmG CDS" gene 699809..700777 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /label="spmG gene" CDS 700801..701712 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388610.1" /db_xref="EnsemblGenomes-Gn:BSU07290" /db_xref="EnsemblGenomes-Tr:CAB12548" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12977" /db_xref="UniProtKB/Swiss-Prot:O06484" /translation="MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHR VLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVT YIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISF KHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGH WNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQ ETLPHIIQHMQTLDPEFNGFASKDDNK*" /label="yfnF CDS" gene 700801..701712 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /label="yfnF gene" promotor_-35 701590..701599 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 701612..701631 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 701615 /Source="Nicolas_upshifts" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" CDS 701741..702919 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388611.1" /db_xref="EnsemblGenomes-Gn:BSU07300" /db_xref="EnsemblGenomes-Tr:CAB12549" /db_xref="GOA:O06483" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12976" /db_xref="UniProtKB/Swiss-Prot:O06483" /translation="MKASVIIPAYNSKERLYNSLLSLNQQECDEEFEVIVADNGSEDG TLSMLESFQADFPLIFTRIKENRGIAYGRNQALRNARGDILIFHDSDMLAAKDLVAKH IKAHENEENLVVCGLFWKRIYSFYYERFEEEHKEQLAKLTGEMPKKDKQKLLEEADIK NGSFLDKSFDLDTDFIDVLKKILDEYGDDLKGYHMPWRFFITNNSSVKRKHVVDLGLF DEGIVRYGFEDYDLGIRLHQAGLTFRLRRDIVSVHQEHPSNCKSVDDIRANIAYMCDK YNNIRSLDVHLAFNGPFPPDMTNRIMADIQKLLESQKYDMLLNLFLELLHVVKERNID PDWRKKSPRVTAKSFDLQTVRKLLPKAKKKLGVNDFANALYALVNDLLHVDLRSLDVV *" /label="yfnE CDS" gene 701741..702919 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /label="yfnE gene" promotor_-35 702460..702466 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 702481..702500 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 702495 /Source="Nicolas_upshifts" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 702920..703855 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388612.1" /db_xref="EnsemblGenomes-Gn:BSU07310" /db_xref="EnsemblGenomes-Tr:CAB12550" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12975" /db_xref="UniProtKB/Swiss-Prot:O31542" /translation="MSTFHFSTIVSRTHIFKLMPMIHSLHEHCDDFHLYVLCVDQKAY ELLQHVPWEHVTFVQLHEMEDPELLKAKSNRTFHEYCWTLKPAFLFHVMSKWDDAEYF AHMDTDLFFFSDPARIFAENPTASLYLTDHRNSPRFMSYYDRTGRFNTGFVGAGNTKE AYEAVWQWRQDCIEFCTVEMDTERKTYGDQRYVEKWPEQFKGVHVVKSIGANTALWNI ENYKVGQKDGRVYIDETPLIFYHFSGFTLVTEKEFNLCWYYRIEDEATIKMIYMPYIL NLKRWIDEIQSAFPDFADGFIPKHAVPDTHFIQLD*" /label="yfnD CDS" gene 702920..703855 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /label="yfnD gene" downshifts 703727 /Source="Nicolas_upshifts" /id="D359" /incds=1 /nref=1 /ntot=52 /MaxReadThrough="5.41459" /MaxDrop="2.6465" /score="34.8532284" /energy="-15.2" /TU="U549,U550" /idTUdmin="U549" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 703837 /Source="Nicolas_upshifts" /id="D360" /incds=0 /nref=2 /ntot=30 /MaxReadThrough="2.32849" /MaxDrop="5.65066" /score="34.8532284" /energy="-15.2" /TU="NA" /idTUdmin="U549" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(703878) /Source="Nicolas_upshifts" /id="D361" /incds=0 /nref=158 /ntot=249 /MaxReadThrough="1.15199" /MaxDrop="4.97014" /score="32.9697757" /energy="-15.2" /TU="NA" /idTUdmin="U552" /TUdmin=13 /isTUend="TRUE" /label="downshifts" CDS complement(703886..705115) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388613.1" /db_xref="EnsemblGenomes-Gn:BSU07320" /db_xref="EnsemblGenomes-Tr:CAB12551" /db_xref="GOA:O06481" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12974" /db_xref="UniProtKB/Swiss-Prot:O06481" /translation="MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMF PILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILG LAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMA PLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENT AITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA IGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSV TVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLG ILAFLLPSDQKLREWHS*" /label="yfnC CDS" gene complement(703886..705115) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /label="yfnC gene" promotor_-10 complement(705144..705163) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(705162) /Source="Nicolas_upshifts" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(705179..705186) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(705226..705933) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine nucleotide phosphatase (promiscuous)" /protein_id="NP_388614.1" /db_xref="EnsemblGenomes-Gn:BSU07330" /db_xref="EnsemblGenomes-Tr:CAB12552" /db_xref="GOA:O06480" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR011951" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3ED5" /db_xref="PDB:3I76" /db_xref="SubtiList:BG12973" /db_xref="UniProtKB/Swiss-Prot:O06480" /translation="MKRYRTLLFDVDDTILDFQAAEALALRLLFEDQNIPLTNDMKAQ YKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYGYEADGALLEQKYRRFLEEGHQLI DGAFDLISNLQQQFDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKPMKEY FNYVFERIPQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPEIIPTYEIR KLEELYHILNIENTVSC*" /label="pynN CDS" gene complement(705226..705933) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /label="pynN gene" downshifts complement(705255) /Source="Nicolas_upshifts" /id="D362" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="2.75071" /MaxDrop="4.28644" /score="1.09492978" /energy="-15.7" /TU="NA" /idTUdmin="U553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(705956..705975) /Source="Nicolas_upshift_promotors" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(705979) /Source="Nicolas_upshifts" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(706025..707410) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12022921, 15849754, 16850406, 17114254, 18632116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 15849754, 16850406, 17114254, 18632116; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methylthioribose permease" /protein_id="NP_388615.1" /db_xref="EnsemblGenomes-Gn:BSU07340" /db_xref="EnsemblGenomes-Tr:CAB12553" /db_xref="GOA:Q797A7" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12972" /db_xref="UniProtKB/Swiss-Prot:Q797A7" /translation="MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGI FVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGEL LAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLP AAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGM KGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTG MMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRD GLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIA VIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYF LYSRKHSLLNK*" /label="mtrA CDS" gene complement(706025..707410) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /label="mtrA gene" downshifts complement(706047) /Source="Nicolas_upshifts" /id="D363" /incds=0 /nref=8 /ntot=91 /MaxReadThrough="3.68565" /MaxDrop="4.73728" /score="31.1617384" /energy="-15.4" /TU="U554" /idTUdmin="U554" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(707459..707478) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(707476) /Source="Nicolas_upshifts" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(707493..707500) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 707578..707585 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 707593 /Source="Nicolas_upshifts" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 707599..707617 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 707660..709117 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /EC_number="1.2.1.67" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15033535, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vanillin dehydrogenase" /protein_id="NP_388616.1" /db_xref="EnsemblGenomes-Gn:BSU07350" /db_xref="EnsemblGenomes-Tr:CAB12554" /db_xref="GOA:O06478" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12971" /db_xref="UniProtKB/Swiss-Prot:O06478" /translation="MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATA DDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKA AFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLS MKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSF VEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAV FSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQ TDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKF DSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGG EKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY*" /label="vdhT CDS" gene 707660..709117 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /label="vdhT gene" promotor_-10 complement(708453..708472) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(708467) /Source="Nicolas_upshifts" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(708485..708494) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 709131..709991 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotaxis sensory transducer (sensed target unknown)" /protein_id="NP_388617.1" /db_xref="EnsemblGenomes-Gn:BSU07360" /db_xref="EnsemblGenomes-Tr:CAB12555" /db_xref="GOA:O06477" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="SubtiList:BG12970" /db_xref="UniProtKB/Swiss-Prot:O06477" /translation="MELTINTEKETADILDAFIKVAPYLNSLVQDDITIGIYDTEKLL VNIPAKTFSLNVKAGDPLQEGDIITDAIRSNQKKTSMVPKELFGFPLIARAIPLHDEN GRVIGGVGLGTSLEESSKLHDVAESLSAVVEQTAAAISDISESINGFSTQMSGISSQA KKVSESAGEIADISVTVKGISDQSNLLGLNAAIEAARAGESGKGFSVVADEIRKLATH SKENVGQIDQITKKIHSLLKGLEESIESINQHTDGQAAAVEQISATMQEISGSAQHLA KMAEKALEEE*" /label="yfmS CDS" gene 709131..709991 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /label="yfmS gene" downshifts 709975 /Source="Nicolas_upshifts" /id="D364" /incds=0 /nref=208 /ntot=237 /MaxReadThrough="2.9987" /MaxDrop="6.02377" /score="31.9989755" /energy="-16.7" /TU="U555" /idTUdmin="U555" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 710059..710066 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 710080..710099 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 710085 /Source="Nicolas_upshifts" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="upshifts" CDS 710126..712015 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /EC_number="3.6.3.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10715006, 16109936, 18848624, 19948254, 24389465, 24389466; Product type r : regulator" /codon_start=1 /transl_table=11 /product="putative energy-dependent translational throttleA" /protein_id="NP_388618.1" /db_xref="EnsemblGenomes-Gn:BSU07370" /db_xref="EnsemblGenomes-Tr:CAB12556" /db_xref="GOA:O06476" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12969" /db_xref="UniProtKB/Swiss-Prot:O06476" /translation="MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKST LLKVIAGLESIEEGEITKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYE KALYELGKDPENEQRQKHLLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELS GGQKKRVAIAKNLIQPADLLILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFL NRVTNRIYELERGSLYTYKGNYEVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGA KARSTKQKARIDRVETLKEQTGPQSSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLV DRFNELVIPGERIGIIGPNGIGKTTLLNALAGRHTPDGGDITIGQTVRIGYYTQDHSE MNGELKVIDYIKETAEVVKTADGDMITAEQMLERFLFPRSMQQTYIRKLSGGEKRRLY LLQVLMQEPNVLFLDEPTNDLDTETLSVLEDYIDQFPGVVITVSHDRYFLDRVVDRLI VFEGNGVISRFQGSYSDYMEESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWD GIEDKIAQLEEKHEQLEADIAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMI EELES*" /label="ettA CDS" gene 710126..712015 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /label="ettA gene" downshifts 711999 /Source="Nicolas_upshifts" /id="D365" /incds=0 /nref=2 /ntot=134 /MaxReadThrough="2.98669" /MaxDrop="2.72484" /score="30.3267801" /energy="-13.8" /TU="U557" /idTUdmin="U557" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" misc_feature 712079..712098 /Source="Nicolas_upshift_promotors" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 712087 /Source="Nicolas_upshifts" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="upshifts" CDS 712138..712584 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26483775" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388619.1" /db_xref="EnsemblGenomes-Gn:BSU07380" /db_xref="EnsemblGenomes-Tr:CAB12557" /db_xref="GOA:O06475" /db_xref="InterPro:IPR019723" /db_xref="SubtiList:BG12968" /db_xref="UniProtKB/Swiss-Prot:O06475" /translation="MTWAIVMLILMSLVKIVLTCLPTGVIEWLLGKFEVHAKLSDENA SLSLDGKRLEGAEKQKVIDQFNEAIFLEKYYIYPGDEERYLHPENGGTPLVIDTKKGK KDVKLFVYRYDDHIDVVKQYKKKVIAYRVLSESLQKESLSVAGSLA*" /label="yfmQ CDS" gene 712138..712584 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /label="yfmQ gene" downshifts complement(712140) /Source="Nicolas_upshifts" /id="D366" /incds=0 /nref=48 /ntot=154 /MaxReadThrough="1.16717" /MaxDrop="4.57866" /score="0.689181271" /energy="-10.2" /TU="NA" /idTUdmin="U559" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(712224..712227) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(712229) /Source="Nicolas_upshifts" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(712245..712246) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 712571 /Source="Nicolas_upshifts" /id="D367" /incds=0 /nref=254 /ntot=267 /MaxReadThrough="3.12706" /MaxDrop="7.87026" /score="13.6774886" /energy="-8" /TU="U558" /idTUdmin="U557" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 712647..712654 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 712668..712687 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 712680 /Source="Nicolas_upshifts" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="upshifts" CDS 712709..713131 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family) of metal(copper) efflux transporter expression" /protein_id="NP_388620.1" /db_xref="EnsemblGenomes-Gn:BSU07390" /db_xref="EnsemblGenomes-Tr:CAB12558" /db_xref="GOA:O06474" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG12967" /db_xref="UniProtKB/Swiss-Prot:O06474" /translation="MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSE DDMEELEKVISTKEVLGFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQE TLNHQLDLIDEKIRTFQSFKERLQGMKGKAERAIQSIE*" /label="copP CDS" gene 712709..713131 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /label="copP gene" downshifts 712967 /Source="Nicolas_upshifts" /id="D368" /incds=1 /nref=2 /ntot=135 /MaxReadThrough="4.24358" /MaxDrop="2.69696" /score="13.6774886" /energy="-8" /TU="U560" /idTUdmin="U558" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS 713197..714387 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14663075, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="metal (copper) efflux transporter" /protein_id="NP_388621.1" /db_xref="EnsemblGenomes-Gn:BSU07400" /db_xref="EnsemblGenomes-Tr:CAB12559" /db_xref="GOA:O06473" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12966" /db_xref="UniProtKB/Swiss-Prot:O06473" /translation="MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAI AAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGS SSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLA GGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTM AVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTV RSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERS IASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGI KAGH*" /label="copO CDS" gene 713197..714387 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /label="copO gene" downshifts complement(714451) /Source="Nicolas_upshifts" /id="D369" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="-0.0437700000000003" /MaxDrop="2.92105" /score="-8.93016606" /energy="-11.6" /TU="NA" /idTUdmin="U562" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS 714678..714833 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388622.1" /db_xref="EnsemblGenomes-Gn:BSU07410" /db_xref="EnsemblGenomes-Tr:CAB12560" /db_xref="SubtiList:BG12965" /db_xref="UniProtKB/Swiss-Prot:O06472" /translation="MDKAKPDEYDQKCLETLYQYIHSVMKNSFSRSSGLPLGKMRRIL SCLPKES*" /label="yfmN CDS" gene 714678..714833 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /label="yfmN gene" CDS complement(714953..716509) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /EC_number="3.6.3.-" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 16109936, 16684363, 22333191, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388623.2" /db_xref="EnsemblGenomes-Gn:BSU07420" /db_xref="EnsemblGenomes-Tr:CAB12571" /db_xref="GOA:O34512" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12964" /db_xref="UniProtKB/Swiss-Prot:O34512" /translation="MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKST FMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMN EIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDV TDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHD IPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFV ARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIG YDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYF EQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVR LCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETW NCESWTTKVL*" /label="ettM CDS" gene complement(714953..716509) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /label="ettM gene" downshifts complement(714977) /Source="Nicolas_upshifts" /id="D370" /incds=0 /nref=173 /ntot=264 /MaxReadThrough="0.35675" /MaxDrop="5.82627" /score="21.7805812" /energy="-12" /TU="NA" /idTUdmin="U562" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 716339..716345 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 716360..716371 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 716377 /Source="Nicolas_upshifts" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(716559..716578) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(716563) /Source="Nicolas_upshifts" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(716594..716598) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 716619..716622 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 716638..716657 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 716641 /Source="Nicolas_upshifts" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" CDS 716682..717812 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11976317; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_388624.1" /db_xref="EnsemblGenomes-Gn:BSU07430" /db_xref="EnsemblGenomes-Tr:CAB12572" /db_xref="GOA:O34750" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12963" /db_xref="UniProtKB/Swiss-Prot:O34750" /translation="MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDV IAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELR AASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVL PEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVK HQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAK KMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRA GKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK*" /label="yfmL CDS" gene 716682..717812 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /label="yfmL gene" downshifts 717795 /Source="Nicolas_upshifts" /id="D371" /incds=0 /nref=43 /ntot=133 /MaxReadThrough="2.93747" /MaxDrop="4.41385" /score="23.4253604" /energy="-5.9" /TU="NA" /idTUdmin="U563" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS 717880..718326 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388625.1" /db_xref="EnsemblGenomes-Gn:BSU07440" /db_xref="EnsemblGenomes-Tr:CAB12573" /db_xref="GOA:O34536" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12962" /db_xref="UniProtKB/Swiss-Prot:O34536" /translation="MASIDRFQVMQEPELKILEHWFENEDTRRRMDGMLLLDEWYARV NKDKHDTVIMAYDGQLPAGMVVIEFGEERTYIGLIVNPLYRLKGYGKQILQKLMTEPD FTSVREWVACIEEDNRISLACFQAAGFTLEDTEPDEDGFLTLILRN*" /label="yfmK CDS" gene 717880..718326 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /label="yfmK gene" CDS complement(718379..719398) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388626.1" /db_xref="EnsemblGenomes-Gn:BSU07450" /db_xref="EnsemblGenomes-Tr:CAB12574" /db_xref="GOA:O34812" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12961" /db_xref="UniProtKB/Swiss-Prot:O34812" /translation="MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLY VSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFS AVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGS TVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDV YFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQG FIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIK VSDPS*" /label="yfmJ CDS" gene complement(718379..719398) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /label="yfmJ gene" downshifts complement(718389) /Source="Nicolas_upshifts" /id="D372" /incds=0 /nref=183 /ntot=252 /MaxReadThrough="2.26899" /MaxDrop="5.73395" /score="20.8047206" /energy="-12.8" /TU="NA" /idTUdmin="U564" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(719419..719438) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(719423) /Source="Nicolas_upshifts" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(719425..719879) /Source="Nicolas_S_feature" /locus_tag="new_818856_819310_c" /HighExp="S2, S1, Pyr, T4.0H, T0.0H, T-2.40H, T3.30H, T-1.40H, T-0.40H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S252" promotor_-35 complement(719451..719458) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 719517..719524 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 719538..719557 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 719545..720642 /Source="Nicolas_S_feature" /locus_tag="new_818976_820073" /HighExp="Etha, dia5, Diami, C30, dia15, T5.0H, S8, T3.0H, M0t90, LPhT" /AntisenseName="yfmI" /AntisenseCor="0.135213889213362" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S253" upshifts 719545 /Source="Nicolas_upshifts" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="upshifts" CDS complement(719880..721100) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388627.1" /db_xref="EnsemblGenomes-Gn:BSU07460" /db_xref="EnsemblGenomes-Tr:CAB12575" /db_xref="GOA:O34440" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12960" /db_xref="UniProtKB/Swiss-Prot:O34440" /translation="MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVT LISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVF IIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAF LGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLR TIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLS ERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQN ITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFS QLQFKKKVNKHISF*" /label="yfmI CDS" gene complement(719880..721100) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /label="yfmI gene" promotor_-10 complement(721137..721156) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(721144) /Source="Nicolas_upshifts" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(721172..721179) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 721198..721205 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 721217..721392 /Source="Nicolas_S_feature" /locus_tag="new_820648_820823" /HighExp="LoTm, T-1.10H, T-0.40H, S3, M9-stat, T0.0H, T-1.40H, BC, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.98260400000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S254" upshifts 721217 /Source="Nicolas_upshifts" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 721220..721239 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 721349 /Source="Nicolas_upshifts" /id="D373" /incds=0 /nref=34 /ntot=117 /MaxReadThrough="8.67835" /MaxDrop="8.45742" /score="4.02328636" /energy="-13.7" /TU="U567" /idTUdmin="U565" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 721436..722899 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388629.1" /db_xref="EnsemblGenomes-Gn:BSU07480" /db_xref="EnsemblGenomes-Tr:CAB12577" /db_xref="InterPro:IPR005532" /db_xref="InterPro:IPR016187" /db_xref="SubtiList:BG12958" /db_xref="UniProtKB/Swiss-Prot:O34722" /translation="MTLLMQDHKSIYNKDIEILIEVEELITSVPENKKNDFKSLIDNR IMTLLNKIQHPVAAENVFGMCIAYPNTYIRYRLIDFVEKWVPYFSAVETIINLTQDPD DLVSFKAMDVCANHKIEESVAYLSSIIDDVRESISYPKKPVGLGAQKVLSTLLDIFGV EKHEELVMLKNYFDQNGILPNNFDFEEKIPQSLIEEFEKTEEDGMILIPGGFFEFGLN ENEIPDKTFNWKDAVPRQKVWLPPFFIDKYPVTNKDYDIFTEFIEENGHIFCHPNEPQ NKQHRRNTYWDDRYLDNHPVTGIDFYDAFAYARYKGKELPTEFQWEKAARGEKGNVWP WGDKFDPAKVQYAGSLYNEPITSLKSWRENLLKAHADKELNHLTSDIFEQNGESPYGV CGMIGGTWEWTRSELKTKRAFHPIFENVPFNSVNSFAVLKGGSFFSHPGLMFPSFRAK DIPFCRHNEMGIRCVKNIPVYKIRESINGPITNKAIY*" /label="yfmG CDS" gene 721436..722899 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /label="yfmG gene" S_feature complement(721801..723471) /Source="Nicolas_S_feature" /locus_tag="new_821232_822902_c" /HighExp="H2O2, C30, Salt, Lbstat, dia15, LPhT, dia5, Paraq, HiOs, Diami" /AntisenseName="yfmG" /AntisenseCor="-0.58045119682782798" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S255" S_feature 722900..723393 /Source="Nicolas_S_feature" /locus_tag="new_822331_822824" /HighExp="LoTm, T0.0H, T-1.40H, T-0.40H, T-2.40H, T-1.10H, Pyr, T-3.40H, SMMPr, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S256" promotor_-35 723381..723386 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 723395..726660 /Source="Nicolas_S_feature" /locus_tag="new_822826_826091" /HighExp="LoTm, Pyr, B36, T3.30H, T2.0H, T-0.40H, T2.30H, B60, T4.0H, T3.0H" /AntisenseName="yfmE" /AntisenseCor="-0.61640022790163695" /AntisenseRegPval="-28.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S257" upshifts 723395 /Source="Nicolas_upshifts" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 723402..723420 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(723472..724272) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16672620, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (ATP-binding protein)" /protein_id="NP_388630.1" /db_xref="EnsemblGenomes-Gn:BSU07490" /db_xref="EnsemblGenomes-Tr:CAB12578" /db_xref="GOA:O34510" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12957" /db_xref="UniProtKB/Swiss-Prot:O34510" /translation="MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKST ILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGR HPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDL LLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKI YNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK*" /label="fecF CDS" gene complement(723472..724272) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /label="fecF gene" CDS complement(724285..725286) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16672620, 16850406, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388631.1" /db_xref="EnsemblGenomes-Gn:BSU07500" /db_xref="EnsemblGenomes-Tr:CAB12579" /db_xref="GOA:O34832" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12956" /db_xref="UniProtKB/Swiss-Prot:O34832" /translation="MKKTTRKQKRPLLAILILAVILIVLSVISIGIGALYISPDAVVT NLLGLDHSFEFIIQQYRLPRIILAILAGAGLAAAGAILQGVIRNPLASPDVVGISKGS GLAAMAVILIFPESPVYVLPFSAFAGAAIIAVLLLMIARKKSIQPSSLALSGIALGAV CHAGMQYMMVKFPGDVNAALIWLTGSLWGRNWEEVKLLAPWLLILFPIVCILIPKLDL MSLGDELAQGLGENANRLRFILIFTAVALAGSCVAVVGSIGFIGLLAPHIARRLTGEK AKYLLPASALIGAIILLIADTLGRGIMPPVEIPAGILTAVIGAPYFLYLLKFEARKQ* " /label="fecE CDS" gene complement(724285..725286) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /label="fecE gene" promotor_-10 complement(724872..724891) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(724884) /Source="Nicolas_upshifts" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(724906..724913) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(725283..726284) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388632.1" /db_xref="EnsemblGenomes-Gn:BSU07510" /db_xref="EnsemblGenomes-Tr:CAB12580" /db_xref="GOA:O34933" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12955" /db_xref="UniProtKB/Swiss-Prot:O34933" /translation="MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSL KYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNA GASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHL FLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSV LGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEH YQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK* " /label="fecD CDS" gene complement(725283..726284) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /label="fecD gene" misc_feature complement(726354..726373) /Source="Nicolas_upshift_promotors" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(726356..727303) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (binding lipoprotein)" /protein_id="NP_388633.1" /db_xref="EnsemblGenomes-Gn:BSU07520" /db_xref="EnsemblGenomes-Tr:CAB12581" /db_xref="GOA:O34348" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12954" /db_xref="UniProtKB/Swiss-Prot:O34348" /translation="MRTYSNKLIAIMSVLLLACLIVSGCSSSQNNNGSGKSESKDSRV IHDEEGKTTVSGTPKRVVVLELSFLDAVHNLGITPVGIADDNKKDMIKKLVGSSIDYT SVGTRSEPNLEVISSLKPDLIIADAERHKNIYKQLKKIAPTIELKSREATYDETIDSF TTIAKALNKEDEGKEKLAEHKKVINDLKAELPKDENRNIVLGVARADSFQLHTSSSYD GEIFKMLGFTHAVKSDNAYQEVSLEQLSKIDPDILFISANEGKTIVDEWKTNPLWKNL KAVKNGQVYDADRDTWTRFRGIKSSETSAKDVLKKVYNK*" /label="fecC CDS" gene complement(726356..727303) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /label="fecC gene" downshifts complement(726375) /Source="Nicolas_upshifts" /id="D374" /incds=0 /nref=41 /ntot=211 /MaxReadThrough="4.92983" /MaxDrop="4.53674" /score="-3.64310934" /energy="-13.9" /TU="U570,U573,U574" /idTUdmin="U570" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" upshifts complement(726375) /Source="Nicolas_upshifts" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 726630..726635 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 726651..726669 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 726662..727287 /Source="Nicolas_S_feature" /locus_tag="new_826093_826718" /HighExp="LoTm, B36, S5, S6, S4, S7, S8, S3, BT, B60" /AntisenseName="yfmC" /AntisenseCor="-0.52042999587715499" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S258" upshifts 726662 /Source="Nicolas_upshifts" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="upshifts" misc_feature 727283..727302 /Source="Nicolas_upshift_promotors" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 727289..727820 /Source="Nicolas_S_feature" /locus_tag="new_826720_827251" /HighExp="LoTm, B36, S5, S4, S7, S6, S8, B60, S3, BT" /AntisenseName="yfmB" /AntisenseCor="-6.4915194654100006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.997, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S259" upshifts 727289 /Source="Nicolas_upshifts" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(727345..727364) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(727352) /Source="Nicolas_upshifts" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(727378..727385) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(727412..727780) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25651892" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388634.1" /db_xref="EnsemblGenomes-Gn:BSU07530" /db_xref="EnsemblGenomes-Tr:CAB12582" /db_xref="InterPro:IPR021579" /db_xref="PDB:2EUC" /db_xref="SubtiList:BG12953" /db_xref="UniProtKB/Swiss-Prot:O34626" /translation="MQYFSPEQQYNAWIVSDLVKQIFHKRAGCSPGIHELAVFAEEHF HIDIDFVFSIIMNIGDIEFALTDEIEKKLSGYLSTLLPYVTADMFETSKANAHAFLSR RHGNAAYHLFVSDDAFMRKQ*" /label="yfmB CDS" gene complement(727412..727780) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /label="yfmB gene" S_feature complement(727781..727893) /Source="Nicolas_S_feature" /locus_tag="new_827212_827324_c" /HighExp="Etha, BC, Sw, M9-stat, T3.30H, T1.30H, T3.0H, T5.0H, T2.30H, T2.0H" /AntisenseName="yfmA" /AntisenseCor="5.8024036419347599E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S260" promotor_-10 complement(727882..727901) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-10" upshifts complement(727893) /Source="Nicolas_upshifts" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="upshifts" promotor_-35 complement(727913..727920) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-35" promotor_-35 727961..727967 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 727981..727999 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 727981 /Source="Nicolas_upshifts" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 728024..728371 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12089032; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heat stress induced protein" /protein_id="NP_388636.1" /db_xref="EnsemblGenomes-Gn:BSU07550" /db_xref="EnsemblGenomes-Tr:CAB12584" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG19020" /db_xref="UniProtKB/Swiss-Prot:P80241" /translation="MKPVVKEYTNDEQLMKDVEELQKMGVAKEDVYVLAHDDDRTERL ADNTNANTIGAKETGFKHAVGNIFNKKGDELRNKIHEIGFSEDEAAQFEKRLDEGKVL LFVTDNEKVKAWA*" /label="yflT CDS" gene 728024..728371 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /label="yflT gene" downshifts complement(728025) /Source="Nicolas_upshifts" /id="D375" /incds=0 /nref=6 /ntot=28 /MaxReadThrough="1.00082" /MaxDrop="4.87687" /score="-3.31058364" /energy="-3.6" /TU="NA" /idTUdmin="U570" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" downshifts 728367 /Source="Nicolas_upshifts" /id="D376" /incds=0 /nref=56 /ntot=197 /MaxReadThrough="6.41566" /MaxDrop="7.61596" /score="-1.88723414" /energy="-5.6" /TU="U575" /idTUdmin="U567" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 728412..728492 /Source="Nicolas_S_feature" /locus_tag="new_827843_827923" /HighExp="Etha, Salt, B36, LoTm, Heat, B60, M9-stat, S8, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S261" misc_feature 728493..728512 /Source="Nicolas_upshift_promotors" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 728494 /Source="Nicolas_upshifts" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="upshifts" CDS 728562..729824 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8262178, 12823818, 27447541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8262178, 12823818, 27447541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pectate lyase" /protein_id="NP_388637.1" /db_xref="EnsemblGenomes-Gn:BSU07560" /db_xref="EnsemblGenomes-Tr:CAB12585" /db_xref="GOA:P39116" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="PDB:1BN8" /db_xref="PDB:2BSP" /db_xref="PDB:2NZM" /db_xref="PDB:2O04" /db_xref="PDB:2O0V" /db_xref="PDB:2O0W" /db_xref="PDB:2O17" /db_xref="PDB:2O1D" /db_xref="PDB:3KRG" /db_xref="PDB:5AMV" /db_xref="SubtiList:BG10840" /db_xref="UniProtKB/Swiss-Prot:P39116" /translation="MKKVMLATALFLGLTPAGANAADLGHQTLGSNDGWGAYSTGTTG GSKASSSNVYTVSNRNQLVSALGKETNTTPKIIYIKGTIDMNVDDNLKPLGLNDYKDP EYDLDKYLKAYDPSTWGKKEPSGTQEEARARSQKNQKARVMVDIPANTTIVGSGTNAK VVGGNFQIKSDNVIIRNIEFQDAYDYFPQWDPTDGSSGNWNSQYDNITINGGTHIWID HCTFNDGSRPDSTSPKYYGRKYQHHDGQTDASNGANYITMSYNYYHDHDKSSIFGSSD SKTSDDGKLKITLHHNRYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSYPFSYAWGIG KSSKIYAQNNVIDVPGLSAAKTISVFSGGTALYDSGTLLNGTQINASAANGLSSSVGW TPSLHGSIDASANVKSNVINQAGAGKLN*" /label="pelA CDS" gene 728562..729824 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /label="pelA gene" downshifts 729819 /Source="Nicolas_upshifts" /id="D377" /incds=0 /nref=139 /ntot=203 /MaxReadThrough="3.61256" /MaxDrop="5.92635" /score="1.82127533" /energy="-8.2" /TU="U575,U576" /idTUdmin="U576" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-35 729877..729880 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 729895..729914 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 729903 /Source="Nicolas_upshifts" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 729951..731387 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12949159, 15849754, 16850406, 25651892, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949159, 15849754, 16850406, 25651892, 28436820; Product type t : transporter" /codon_start=1 /transl_table=11 /product="malate (2-oxoglutarate) transporter" /protein_id="NP_388638.1" /db_xref="EnsemblGenomes-Gn:BSU07570" /db_xref="EnsemblGenomes-Tr:CAB12586" /db_xref="GOA:O34726" /db_xref="InterPro:IPR001898" /db_xref="InterPro:IPR030676" /db_xref="SubtiList:BG12951" /db_xref="UniProtKB/Swiss-Prot:O34726" /translation="MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHL FAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFI SRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPII RSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGV DLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSE LSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTW FAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHI SAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWW SIGFILSIVHIIVWLVIGGLWWKVLGIW*" /label="maeS CDS" gene 729951..731387 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /label="maeS gene" downshifts 731379 /Source="Nicolas_upshifts" /id="D378" /incds=0 /nref=56 /ntot=132 /MaxReadThrough="2.39993" /MaxDrop="5.36125" /score="40.3051497" /energy="-9.7" /TU="NA" /idTUdmin="U577" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature 731478..731497 /Source="Nicolas_upshift_promotors" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 731489 /Source="Nicolas_upshifts" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="upshifts" CDS 731514..733142 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388639.1" /db_xref="EnsemblGenomes-Gn:BSU07580" /db_xref="EnsemblGenomes-Tr:CAB12587" /db_xref="GOA:O34427" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12576" /db_xref="UniProtKB/Swiss-Prot:O34427" /translation="MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQ AEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIR SASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVD FLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRER NAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKG EMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDL RAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILL GKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLF FITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWI ELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG*" /label="citS CDS" gene 731514..733142 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /label="citS gene" CDS 733114..733794 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388640.1" /db_xref="EnsemblGenomes-Gn:BSU07590" /db_xref="EnsemblGenomes-Tr:CAB12588" /db_xref="GOA:O34534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR028141" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12577" /db_xref="UniProtKB/Swiss-Prot:O34534" /translation="MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLK EHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYL IKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSI TLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPE RKYYLAAD*" /label="citT CDS" gene 733114..733794 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /label="citT gene" CDS 733797..734756 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11029430; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative tricarboxylate transporter component" /protein_id="NP_388641.2" /db_xref="EnsemblGenomes-Gn:BSU07600" /db_xref="EnsemblGenomes-Tr:CAB12589" /db_xref="GOA:O34439" /db_xref="InterPro:IPR005064" /db_xref="SubtiList:BG12950" /db_xref="UniProtKB/Swiss-Prot:O34439" /translation="MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGW DVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDL LGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFG NDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNG DITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKV TSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN*" /label="yflP CDS" gene 733797..734756 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /label="yflP gene" downshifts 734725 /Source="Nicolas_upshifts" /id="D379" /incds=0 /nref=76 /ntot=211 /MaxReadThrough="1.1681" /MaxDrop="6.31244" /score="10.4510496" /energy="-6.5" /TU="NA" /idTUdmin="U578" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 734848..734855 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 734868..734887 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 734879..734951 /Source="Nicolas_S_feature" /locus_tag="new_834310_834382" /HighExp="M9-stat, SMMPr, SMM, T0.0H, LoTm, T1.0H, Pyr, T1.30H, Cold, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S262" upshifts 734879 /Source="Nicolas_upshifts" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="upshifts" CDS 734952..736253 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="transporter of divalent metal ions/citrate complexes" /protein_id="NP_388642.1" /db_xref="EnsemblGenomes-Gn:BSU07610" /db_xref="EnsemblGenomes-Tr:CAB12590" /db_xref="GOA:P55069" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11832" /db_xref="UniProtKB/Swiss-Prot:P55069" /translation="MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFT EVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGT AVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGAT PRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEP AAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQR QRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVAL TSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHL LVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV*" /label="citM CDS" gene 734952..736253 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /label="citM gene" promotor_-35 736250..736256 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 736270..736281 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 736271 /Source="Nicolas_upshifts" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="upshifts" CDS 736309..737103 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10972810, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388643.1" /db_xref="EnsemblGenomes-Gn:BSU07620" /db_xref="EnsemblGenomes-Tr:CAB12591" /db_xref="GOA:O34409" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12949" /db_xref="UniProtKB/Swiss-Prot:O34409" /translation="MSDPYMPLTSVRSGAGFEAAKGVHGLTVQIANVYFIQLPSEPHS FVLIDAGMPQSAGVIVNEAKQRFGEGFQLKAIILTHGHFDHIGAIEEILEHWDVPVYI HSREMPYVTGKEDYPPARPDSKSGLVAKLSPLFPRHSIDISSHVQALPEDGSVPFLDE WMWIATPGHTPGHISLFRDDGRVLVAGDAVITVEQEKMADVLIQKQELHGPPAYFTPD TETAAESILKLAGLEPEALLTGHGIPMTGKNFRSDLTELANRLSSI*" /label="yflN CDS" gene 736309..737103 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /label="yflN gene" downshifts 737079 /Source="Nicolas_upshifts" /id="D380" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="0.0114999999999998" /MaxDrop="3.05232" /score="38.3109333" /energy="-11.8" /TU="NA" /idTUdmin="U580" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-35 737158..737161 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 737176..737195 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 737189 /Source="Nicolas_upshifts" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="upshifts" CDS 737222..738313 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /EC_number="1.14.13.39" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11856757, 12220171, 16172391, 25643072, 25826316, 26062720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11856757, 12220171, 16172391, 25643072, 25826316, 26062720; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitric-oxide synthase" /protein_id="NP_388644.2" /db_xref="EnsemblGenomes-Gn:BSU07630" /db_xref="EnsemblGenomes-Tr:CAB12592" /db_xref="GOA:O34453" /db_xref="InterPro:IPR004030" /db_xref="InterPro:IPR017142" /db_xref="InterPro:IPR036119" /db_xref="PDB:1M7V" /db_xref="PDB:1M7Z" /db_xref="PDB:2AMO" /db_xref="PDB:2AN0" /db_xref="PDB:2AN2" /db_xref="PDB:2FBZ" /db_xref="PDB:2FC1" /db_xref="PDB:2FC2" /db_xref="PDB:4D3I" /db_xref="PDB:4D3J" /db_xref="PDB:4D3K" /db_xref="PDB:4D3M" /db_xref="PDB:4D3N" /db_xref="PDB:4D3O" /db_xref="PDB:4D3T" /db_xref="PDB:4D3U" /db_xref="PDB:4D3V" /db_xref="PDB:4D7H" /db_xref="PDB:4D7I" /db_xref="PDB:4D7J" /db_xref="PDB:4LWA" /db_xref="PDB:4LWB" /db_xref="PDB:4UG5" /db_xref="PDB:4UG6" /db_xref="PDB:4UG7" /db_xref="PDB:4UG8" /db_xref="PDB:4UG9" /db_xref="PDB:4UGA" /db_xref="PDB:4UGB" /db_xref="PDB:4UGC" /db_xref="PDB:4UGD" /db_xref="PDB:4UGE" /db_xref="PDB:4UGF" /db_xref="PDB:4UGG" /db_xref="PDB:4UGH" /db_xref="PDB:4UGI" /db_xref="PDB:4UGJ" /db_xref="PDB:4UGK" /db_xref="PDB:4UGL" /db_xref="PDB:4UGM" /db_xref="PDB:4UGN" /db_xref="PDB:4UGO" /db_xref="PDB:4UGP" /db_xref="PDB:4UGQ" /db_xref="PDB:4UGR" /db_xref="PDB:4UGS" /db_xref="PDB:4UGT" /db_xref="PDB:4UGU" /db_xref="PDB:4UGV" /db_xref="PDB:4UGW" /db_xref="PDB:4UGX" /db_xref="PDB:4UGY" /db_xref="PDB:4UQR" /db_xref="PDB:4UQS" /db_xref="PDB:5G65" /db_xref="PDB:5G66" /db_xref="PDB:5G67" /db_xref="PDB:5G68" /db_xref="PDB:5G69" /db_xref="PDB:5G6A" /db_xref="PDB:5G6B" /db_xref="PDB:5G6C" /db_xref="PDB:5G6D" /db_xref="PDB:5G6E" /db_xref="PDB:5G6F" /db_xref="PDB:5G6G" /db_xref="PDB:5G6H" /db_xref="PDB:5G6I" /db_xref="PDB:5G6J" /db_xref="PDB:5G6K" /db_xref="PDB:5G6L" /db_xref="PDB:5G6M" /db_xref="PDB:5G6N" /db_xref="PDB:5G6O" /db_xref="PDB:5G6P" /db_xref="PDB:5G6Q" /db_xref="SubtiList:BG12948" /db_xref="UniProtKB/Swiss-Prot:O34453" /translation="MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGS YVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATN NGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGW RGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPII SDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLW KDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPI SPAATHIFHRSYDNSIVKPNYFYQDKPYE*" /label="nosA CDS" gene 737222..738313 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /label="nosA gene" CDS complement(738304..738579) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /EC_number="3.6.1.7" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:20447399" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20447399; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphatase" /protein_id="NP_388645.1" /db_xref="EnsemblGenomes-Gn:BSU07640" /db_xref="EnsemblGenomes-Tr:CAB12593" /db_xref="GOA:O35031" /db_xref="InterPro:IPR001792" /db_xref="InterPro:IPR017968" /db_xref="InterPro:IPR020456" /db_xref="InterPro:IPR036046" /db_xref="PDB:2FHM" /db_xref="PDB:2HLT" /db_xref="PDB:2HLU" /db_xref="PDB:3BR8" /db_xref="SubtiList:BG12947" /db_xref="UniProtKB/Swiss-Prot:O35031" /translation="MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEI LAEGPENALQSFVEAVKNGSPFSKVTDISVTESRSLEGHHRFSIVYS*" /label="acyP CDS" gene complement(738304..738579) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /label="acyP gene" S_feature 738314..738645 /Source="Nicolas_S_feature" /locus_tag="new_837745_838076" /HighExp="C90, BI, Paraq, LBGexp, Oxctl, M0t45, G150, M40t45, G135, H2O2" /AntisenseName="yflL" /AntisenseCor="0.38657275217332299" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S263" promotor_-10 complement(738593..738612) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(738607) /Source="Nicolas_upshifts" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(738627..738634) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 738646..739311 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11886751; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur carrier" /protein_id="NP_388646.1" /db_xref="EnsemblGenomes-Gn:BSU07650" /db_xref="EnsemblGenomes-Tr:CAB12594" /db_xref="GOA:O34542" /db_xref="InterPro:IPR005163" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="SubtiList:BG12946" /db_xref="UniProtKB/Swiss-Prot:O34542" /translation="MKQERYSVLSLNLGKPQTLEYDGKKIETGIMKRPAKSAVMLYRE NFEGDGQADLVNHGGPDKAVCVYPAEHYPFWEEFLSRPLSNAAFGENLTVAGLTEENV CIGDVFRLDEAVVQVSQPRQPCVKLAKKFGVKEMVLKVQQTGYTGFYFRVLEEGRVSP GANLELLSRGEKGISVQFANRINYHDAKNLTAIERILSEAALSESWRASFMKKKDRLL PVE*" /label="yflK CDS" gene 738646..739311 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /label="yflK gene" CDS complement(739352..739489) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388647.1" /db_xref="EnsemblGenomes-Gn:BSU07660" /db_xref="EnsemblGenomes-Tr:CAB12595" /db_xref="InterPro:IPR022580" /db_xref="SubtiList:BG12945" /db_xref="UniProtKB/Swiss-Prot:O34345" /translation="MHYGSKGWYVAELKKQGITHHEGRKLQSYKTYFLANLLESKKKQ S*" /label="yflJ CDS" gene complement(739352..739489) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /label="yflJ gene" downshifts complement(739366) /Source="Nicolas_upshifts" /id="D381" /incds=0 /nref=136 /ntot=260 /MaxReadThrough="0.0927600000000002" /MaxDrop="8.10929" /score="29.8336543" /energy="-14.8" /TU="NA" /idTUdmin="U583" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(739490..739620) /Source="Nicolas_S_feature" /locus_tag="new_838921_839051_c" /HighExp="S4, S7, S8, S6, S5, S3, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.967, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S264" promotor_-10 complement(739606..739624) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 739616..739621 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(739620) /Source="Nicolas_upshifts" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 739631..740695 /Source="Nicolas_S_feature" /locus_tag="new_839062_840126" /HighExp="S8, S6, S5, S7, S4, S3, BT, B36, C90, T5.0H" /AntisenseName="mapB" /AntisenseCor="-0.26446079057314398" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S265" upshifts 739632 /Source="Nicolas_upshifts" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 739637..739655 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(739640..739645) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(739646..739801) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388648.1" /db_xref="EnsemblGenomes-Gn:BSU07670" /db_xref="EnsemblGenomes-Tr:CAB12596" /db_xref="GOA:O34905" /db_xref="SubtiList:BG12944" /db_xref="UniProtKB/Swiss-Prot:O34905" /translation="MWFIIFGIIFFIEGIIMTVYGVKKKNGMLTYIGIVFAIMTFGVV MIKLTGH*" /label="yflI CDS" gene complement(739646..739801) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /label="yflI gene" S_feature complement(739802..739907) /Source="Nicolas_S_feature" /locus_tag="new_839233_839338_c" /HighExp="Etha, Salt, Diami, dia15, H2O2, Cold, G135, Paraq, LPhT, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S266" CDS complement(739908..740222) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1070366, 1266368; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388649.1" /db_xref="EnsemblGenomes-Gn:BSU07680" /db_xref="EnsemblGenomes-Tr:CAB12597" /db_xref="InterPro:IPR021637" /db_xref="PDB:3D0W" /db_xref="SubtiList:BG12943" /db_xref="UniProtKB/Swiss-Prot:O34306" /translation="MNRDQEKIQIENEMNAMHGTIKEDILKDFEEFKGYLKKQVNRGK KLGLDDGKLVKSAAILGDYLAKHEEPQNGEEMLLQELWSVADEDEKEHLAQLLVKLVD KQ*" /label="yflH CDS" gene complement(739908..740222) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /label="yflH gene" S_feature complement(740223..740303) /Source="Nicolas_S_feature" /locus_tag="new_839654_839734_c" /HighExp="dia5, dia15, Diami, LBGtran, LPhT, H2O2, Etha, Lbtran, M40t45, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S267" CDS complement(740304..741053) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase B" /protein_id="NP_388650.1" /db_xref="EnsemblGenomes-Gn:BSU07690" /db_xref="EnsemblGenomes-Tr:CAB12598" /db_xref="GOA:O34484" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG12942" /db_xref="UniProtKB/Swiss-Prot:O34484" /translation="MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGK AVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGF YSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFT VIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDG WTFKTPDKSMVAQVEHTIVITKDEPIILTKL*" /label="mapB CDS" gene complement(740304..741053) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /label="mapB gene" promotor_-10 complement(741082..741101) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(741095) /Source="Nicolas_upshifts" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(741097..742233) /Source="Nicolas_S_feature" /locus_tag="new_840528_841664_c" /HighExp="S6, S8, S7, S5, BT, C30, Paraq, B36, G180, Pyr" /AntisenseName="nagP" /AntisenseCor="0.180776000778922" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S268" promotor_-35 complement(741113..741121) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 741164..741165 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 741185..741204 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 741188 /Source="Nicolas_upshifts" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="upshifts" CDS 741225..742583 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 8246840; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) N-acetylglucosamine-specific enzyme IICB component" /protein_id="NP_388651.1" /db_xref="EnsemblGenomes-Gn:BSU07700" /db_xref="EnsemblGenomes-Tr:CAB12599" /db_xref="GOA:O34521" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010974" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG12941" /db_xref="UniProtKB/Swiss-Prot:O34521" /translation="MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGT AVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIA GLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSF GEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPT AGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFA FMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVG ICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQ TIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAA VK*" /label="nagP CDS" gene 741225..742583 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /label="nagP gene" promotor_-10 complement(742219..742238) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(742233) /Source="Nicolas_upshifts" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(742252..742261) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 742469 /Source="Nicolas_upshifts" /id="D382" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="3.67421" /MaxDrop="3.12268" /score="44.7832762" /energy="-16.9" /TU="U586" /idTUdmin="U586" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 742579 /Source="Nicolas_upshifts" /id="D383" /incds=0 /nref=2 /ntot=87 /MaxReadThrough="2.54331" /MaxDrop="3.17508" /score="44.7832762" /energy="-16.9" /TU="NA" /idTUdmin="U586" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(742616..744565) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10658653, 21255105" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658653, 21255105; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_388652.1" /db_xref="EnsemblGenomes-Gn:BSU07710" /db_xref="EnsemblGenomes-Tr:CAB12600" /db_xref="GOA:O34952" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="PDB:2W8D" /db_xref="SubtiList:BG12940" /db_xref="UniProtKB/Swiss-Prot:O34952" /translation="MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKIL LFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVI MQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASS ILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSS DVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKL AHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKS KNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESM PLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQ FFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIH AAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFIS PKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKK VNPSDYDYTKHDEDSSETSKDNEDK*" /label="ltaSB CDS" gene complement(742616..744565) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /label="ltaSB gene" downshifts complement(742633) /Source="Nicolas_upshifts" /id="D384" /incds=0 /nref=219 /ntot=250 /MaxReadThrough="1.71031" /MaxDrop="6.08461" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U589" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 743675..743681 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 743697..743715 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 743701..744665 /Source="Nicolas_S_feature" /locus_tag="new_843132_844096" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, S8, B60, BC, S7" /AntisenseName="yflE" /AntisenseCor="-0.385555454026206" /AntisenseRegPval="-10.199999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S269" upshifts 743701 /Source="Nicolas_upshifts" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(744566..744640) /Source="Nicolas_S_feature" /locus_tag="new_843997_844071_c" /HighExp="Paraq, H2O2, LBGexp, G150, G135, G180, Lbexp, C30, LPhT, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S270" promotor_-10 complement(744617..744636) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(744640) /Source="Nicolas_upshifts" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(744642..745164) /Source="Nicolas_S_feature" /locus_tag="new_844073_844595_c" /HighExp="S3, LoTm, S7, S4, S5, S8, S6, M9-stat, C30, Pyr" /AntisenseName="yflD" /AntisenseCor="0.24383322556613099" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S271" promotor_-35 complement(744652..744656) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 744666..744803 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388653.1" /db_xref="EnsemblGenomes-Gn:BSU07720" /db_xref="EnsemblGenomes-Tr:CAB12601" /db_xref="SubtiList:BG12939" /db_xref="UniProtKB/Swiss-Prot:O34489" /translation="MREKVAKNAVESTFRFDITKCKTRYLSRNKGIKWYIENCMIKYK V*" /label="yflD CDS" gene 744666..744803 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /label="yflD gene" upshifts 744781 /Source="Nicolas_upshifts" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="upshifts" misc_feature 744782..744801 /Source="Nicolas_upshift_promotors" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 744822..745214 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388655.2" /db_xref="EnsemblGenomes-Gn:BSU07735" /db_xref="EnsemblGenomes-Tr:CAB12603" /db_xref="InterPro:IPR018961" /db_xref="SubtiList:BG12937" /db_xref="UniProtKB/Swiss-Prot:O34887" /translation="MDFSHIVSEDKIKRAIKDGDFQNLPGMGKPLPKDDAAHLPESLR MGYRILKNAGMAEDEGALKKELMTIDHLIEKCYDEKEREQLIRKKSEKQLLLDKLVDK KGMFSKPASAFYKNKVYDRLGRNRPSSS*" /label="yflB CDS" gene 744822..745214 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /label="yflB gene" promotor_-10 complement(745162..745180) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(745177) /Source="Nicolas_upshifts" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(745196..745201) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 745283..745289 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 745304..745322 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 745304 /Source="Nicolas_upshifts" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="upshifts" CDS 745339..746754 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid transporter" /protein_id="NP_388656.1" /db_xref="EnsemblGenomes-Gn:BSU07750" /db_xref="EnsemblGenomes-Tr:CAB12604" /db_xref="GOA:O34708" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12936" /db_xref="UniProtKB/Swiss-Prot:O34708" /translation="MERLLVWIEHISDWLWGPPLIILLTGTGLYFTILLKGFQFRYPL YIFKQTIGSVGKKPKGEGTVTPLQALTSALSSTIGAANIVGVPAAIMFGGPGAVFWMW LIALFAMAIKFSESVLAVHYREKNEQGEYVGGPMYYITKGLRMKWLGVFFSVALIVEL IPSIMVQGNSVSVSLAETFSFNKIYAGIGIAFLIGLVVIGGVKRIGKVTEFVVPLMAG AYAGAGLLIVLMNLSSVPAFFSLVFSNAFTSSSAVGGFAGAALAETVRWGFARGLYSN EAGMGTAPIAHAAAMTDHPVRQGFWSVIGIVIDTLIICTTTAFIVLASGVWTGKNASN DPAALTTAAFQHYFGSGGGYFVSVSLVFFVVSTIMVVIFYGVKQAEFLFGRLAGHVIK FVYLAAIIIGAAGGAKAIWGVLDLALVFIVVPNVIALLLLSRKVKALYTEFFTSEQYY LKDIRKTKQKPVYPTKEAKNS*" /label="yflA CDS" gene 745339..746754 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /label="yflA gene" downshifts complement(745340) /Source="Nicolas_upshifts" /id="D385" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="0.76492" /MaxDrop="4.20973" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U593" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(745366..745466) /Source="Nicolas_upshift_promotors" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(745406) /Source="Nicolas_upshifts" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(746751..747827) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406, 23625846; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane transporter" /protein_id="NP_388657.1" /db_xref="EnsemblGenomes-Gn:BSU07760" /db_xref="EnsemblGenomes-Tr:CAB12605" /db_xref="GOA:O34573" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG12935" /db_xref="UniProtKB/Swiss-Prot:O34573" /translation="MDKTSAYQGLFFGALYTLAVGLKHAPILMIESAKQNAWHSYILG VVIVIPALWLMHRLMKKHQDKNIYELLSDSSPIAGRIIILLFSLYFLLINAHDIRFFI NLINILFLPRTPMAVLGGVIIFVAICIAREGKETLTRMAQIFLFPFGILVLFLPFTLA TQIELQNLTPVFEGLIPYLQSGYYAFGTMGELIILPLLFSNRSVPLKYTIFAILLGAL LLAVMLFSSISVFGPNLTSTFFDPAYMVIRQIRITDFLDRSDLIIAAFWIPVIMVKIA GSLYIVVYGLSFLHSKIDPKAMYTPTGMFSVVCGFWFFLNTNQLIDFNRIKPIINVVI SLLLPLLIYLIIKSKALFGAKAKH*" /label="yfkT CDS" gene complement(746751..747827) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /label="yfkT gene" S_feature 746755..750121 /Source="Nicolas_S_feature" /locus_tag="new_846186_849552" /HighExp="Salt, Sw, Etha, LoTm, B36, Heat, LPhT, BC, T0.30H, H2O2" /AntisenseName="yfkR" /AntisenseCor="-1.3937740774571999E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.952" /label="S272" CDS complement(747851..748051) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative spore germination D protein" /protein_id="NP_388658.1" /db_xref="EnsemblGenomes-Gn:BSU07770" /db_xref="EnsemblGenomes-Tr:CAB12606" /db_xref="GOA:O35036" /db_xref="SubtiList:BG12934" /db_xref="UniProtKB/Swiss-Prot:O35036" /translation="MISYIVQTLIVCIAIYAYEWKNFRSANNLTKWAFSLLIAGSAFL WIYMRVNPLLPRLGHLFKYIPF*" /label="yfkS CDS" gene complement(747851..748051) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /label="yfkS gene" CDS complement(748067..749221) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388659.1" /db_xref="EnsemblGenomes-Gn:BSU07780" /db_xref="EnsemblGenomes-Tr:CAB12607" /db_xref="GOA:O35028" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG12933" /db_xref="UniProtKB/Swiss-Prot:O35028" /translation="MKKTIYKCVLPLLICILLTGCWDRTEINDIAFVVSSAIDKKKDQ YRVAMQIPLVGQLGGQTGGGGGTAGSKTWYVDSASGTTIREANNKLQTSLSRTINTSH RRTVIIGEDMARDGVAPVFDILTRNPQNRLTALILVSRGEARDILNTDVQLEQFPAEM IRELAIIATSRPVFLSRFMSDLVEIGSDPYAPVISASKTKPGGKGKSNLKIDGLAIFK KDRLMDIFKDEHMTAALMLLNQARQPEFIVDLPNQMGQASIQLQKSNASFHAAEKNGK LSMTIEIRAKGIIMENQSTYETRENDQYYIIQKALNRTIKKDVISTVHRLQKLKADPA GFQDRTIRSTATTKNLLKKEWEEVYKDMEVHVVPIVTIEQGGVLYKTISH*" /label="yfkR CDS" gene complement(748067..749221) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /label="yfkR gene" CDS complement(749202..750743) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388660.1" /db_xref="EnsemblGenomes-Gn:BSU07790" /db_xref="EnsemblGenomes-Tr:CAB12608" /db_xref="GOA:O34486" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG12932" /db_xref="UniProtKB/Swiss-Prot:O34486" /translation="MNKRDKALQLIKELEDNQDRPISPNLKENLENLTLLTEGCSDIV FRQFDFGNGLCGFIVYIEGIVKSEHIQDHALRPFLMHLTDQIDEHEEALQNTLSISSV ALETSMSKVAASIIEGNAVLFADGHSKGLILNIKGGQRRSIEEPITESTIRGSREGFT ESLRVNTALVRFRVKTFQLKMISFKIGTKTKTDVVLAYIDGLADPKVIDKAKKRIKKI KIDAVLESGYIEEFIEDDTYSPFPQLQYTERPDTVAAQLLEGRFAIFTDNTPFVLTGP ITFWQLMQASEDYYERYLMSNLIRWLRYMFLFVALYLPAIYVAVITYHQDLMPTNLMF SVASAREPIPFPAIIEALIMEISFEALREAGVRLPKTIGQTVSILGALVIGTAAVEAG IVSAPMVIIVSLTGIASFTIPRFNLAISIRMLRFPLMFLASIFGIFGIMLGTIILVLH LCKLQSFGIPYLSGISPFKRDEVKDIFVRAPWWTMTRRPGTYSRGNGQKGAKREDPKD EENNI*" /label="yfkQ CDS" gene complement(749202..750743) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /label="yfkQ gene" promotor_-10 complement(750793..750804) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(750796) /Source="Nicolas_upshifts" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(750818..750824) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 750853..750860 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 750875..750894 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 750882 /Source="Nicolas_upshifts" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(750928) /Source="Nicolas_upshifts" /id="D386" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="1.35091" /MaxDrop="3.57201" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U596" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 750936..752348 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /EC_number="2.7.1.201" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 8755887, 8917076, 8969503, 18977770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 8755887, 8917076, 8969503, 18977770; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) trehalose-specific enzyme IIBC component" /protein_id="NP_388661.1" /db_xref="EnsemblGenomes-Gn:BSU07800" /db_xref="EnsemblGenomes-Tr:CAB12609" /db_xref="GOA:P39794" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011296" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11009" /db_xref="UniProtKB/Swiss-Prot:P39794" /translation="MGELNKSARQIVEAVGGAENIAAATHCVTRLRFALIDESKVDQE MLDQIDVVKGSFSTNGQFQVVIGQGTVNKVYAELVKETGIGESTKDEVKKASEKNMNP LQRAVKTLADIFIPILPAIVTAGLLMGINNILTAEGIFFSTKSIVQVYPQWADLANMI NLIAGTAFTFLPALIGWSAVKRFGGNPLLGIVLGVMLVHPDLLNAWGYGAAEQSGEIP VWNLFGLEVQKVGYQGQVLPILLASYMLAKIEVFLTKRTPEGIQLLVVAPITLLLTGF ASFIIIGPITFAIGNVLTSGLISVFGSFAALGGLLYGGFYSALVITGMHHTFLAVDLQ LIGSKLGGTFLWPMLALSNIAQGSAALAMMFIVKDEKQKGLSLTSGISAYLGITEPAI FGVNLRYRFPFIIAMVSSGLAGMYISSQGVLASSVGVGGVPGIFSIMSQYWGAFAIGM AIVLIVPFAGTYAYARFKHK*" /label="treP CDS" gene 750936..752348 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /label="treP gene" promotor_no_box complement(750954..751054) /Source="Nicolas_upshift_promotors" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(750994) /Source="Nicolas_upshifts" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 752419..754104 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /EC_number="3.2.1.93" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651129, 7751281, 8755887, 8917076, 9701821, 26894535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651129, 7751281, 8755887, 8917076, 9701821, 26894535; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trehalose-6-phosphate hydrolase" /protein_id="NP_388662.1" /db_xref="EnsemblGenomes-Gn:BSU07810" /db_xref="EnsemblGenomes-Tr:CAB12610" /db_xref="GOA:P39795" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR012769" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG11010" /db_xref="UniProtKB/Swiss-Prot:P39795" /translation="MKTEQTPWWKKAVVYQIYPKSFNDTTGNGVGDLNGIIEKLDYLK TLQVDVLWLTPIYDSPQHDNGYDIRDYYSIYPEYGTMEDFERLVSEAHKRDLKVVMDL VVNHTSTEHKWFREAISSIDSPYRDFYIWKKPQENGSVPTNWESKFGGSAWELDEASG QYYLHLFDVTQADLNWENEEVRKHVYDMMHFWFEKGIDGFRLDVINLISKDQRFPNAE EGDGRSFYTDGPRVHEFLHEMNEKVFSHYDSMTVGEMSSTTVDHCIRYTNPDNKELDM TFSFHHLKVDYPNGEKWALAPFDFLKLKEILSDWQTGMHAGGGWNALFWCNHDQPRVV SRYGDDGAYRVKSAKMLATAIHMMQGTPYIYQGEELGMTNPKFTDISSYRDVESLNMY HAFKEKGMADQDITAILQAKSRDNSRTPVQWDATENGGFTTGTPWIPVAGNYREINAE AALRDQNSVFYHYQKLIQIRKMYDIVTEGTYEIIAKDDPNIFAYLRHGSNEKLLVINN FYGTEAAFTLPDSLAPDEWKAEVLLTNDEAREGLQNMTLRPYESIVYRLTKPC*" /label="treA CDS" gene 752419..754104 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /label="treA gene" promotor_-10 complement(752725..752740) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(752732) /Source="Nicolas_upshifts" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(752753..752762) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 754077..754081 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 754097..754116 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 754100 /Source="Nicolas_upshifts" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 754125..754841 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755887, 9829827, 17705272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755887, 9829827, 17705272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TreR-trehalose)" /protein_id="NP_388663.1" /db_xref="EnsemblGenomes-Gn:BSU07820" /db_xref="EnsemblGenomes-Tr:CAB12611" /db_xref="GOA:P39796" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR012770" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OGG" /db_xref="SubtiList:BG11011" /db_xref="UniProtKB/Swiss-Prot:P39796" /translation="MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRET VRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKF GLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQY TESRHRLDKFRFVDFARRGK*" /label="treR CDS" gene 754125..754841 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /label="treR gene" downshifts 754834 /Source="Nicolas_upshifts" /id="D387" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="6.58905" /MaxDrop="4.05981" /score="24.6748216" /energy="-11.1" /TU="U595,U598" /idTUdmin="U595" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" promotor_-35 754916..754919 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 754935..754954 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 754944 /Source="Nicolas_upshifts" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 754981..755646 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /EC_number="1.5.1.39" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15252706, 20727918, 20862523, 22238377, 26415543" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 20727918, 20862523, 22238377, 26415543; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H-flavin oxidoreductase (nitroreductase)" /protein_id="NP_388664.1" /db_xref="EnsemblGenomes-Gn:BSU07830" /db_xref="EnsemblGenomes-Tr:CAB12612" /db_xref="GOA:O34475" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="InterPro:IPR033878" /db_xref="SubtiList:BG12931" /db_xref="UniProtKB/Swiss-Prot:O34475" /translation="MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPS SLGLEPWKFVVVQNPEFREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKR HLKEVKQMPQDVYEGYLSKTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQ IGVDSCPIEGFQYDHIHRILEEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVV KWV*" /label="hypO CDS" gene 754981..755646 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /label="hypO gene" downshifts 755627 /Source="Nicolas_upshifts" /id="D388" /incds=0 /nref=180 /ntot=269 /MaxReadThrough="0.70079" /MaxDrop="6.77615" /score="34.5750428" /energy="-16.9" /TU="NA" /idTUdmin="U595" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(755683..760071) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /EC_number="3.1.4.16" /EC_number="3.1.3.5" /EC_number="3.1.3.6" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14688230, 16291680, 21800427, 21906378, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase" /protein_id="NP_388665.1" /db_xref="EnsemblGenomes-Gn:BSU07840" /db_xref="EnsemblGenomes-Tr:CAB12613" /db_xref="GOA:O34313" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="PDB:3GVE" /db_xref="SubtiList:BG12930" /db_xref="UniProtKB/Swiss-Prot:O34313" /translation="MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVH LSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGN PLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADF PIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEG QVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGID AIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSW KVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKD DPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIK NVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDV IDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGG GGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLL AKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLD DAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGN HEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQT FTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVK AIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIV AQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELED VKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAG IDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYT FTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGED LGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANT PFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADT AIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDR KKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGG SDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILL AGFLISALGTAMYLHQRRKQNRANQA*" /label="yfkN CDS" gene complement(755683..760071) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /label="yfkN gene" downshifts complement(755702) /Source="Nicolas_upshifts" /id="D389" /incds=0 /nref=155 /ntot=229 /MaxReadThrough="1.00159" /MaxDrop="7.08591" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(760104..760123) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(760121) /Source="Nicolas_upshifts" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(760138..760141) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 760248..760254 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 760268..760286 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 760271 /Source="Nicolas_upshifts" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 760314..760832 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="general stress protein 18; deglycase" /protein_id="NP_388666.1" /db_xref="EnsemblGenomes-Gn:BSU07850" /db_xref="EnsemblGenomes-Tr:CAB12614" /db_xref="GOA:P80876" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12929" /db_xref="UniProtKB/Swiss-Prot:P80876" /translation="MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVK GKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFA ICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIP AFNRESLALLEK*" /label="sufLB CDS" gene 760314..760832 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /label="sufLB gene" downshifts 760818 /Source="Nicolas_upshifts" /id="D390" /incds=0 /nref=35 /ntot=153 /MaxReadThrough="8.02255" /MaxDrop="6.97573" /score="42.2080398" /energy="-12.9" /TU="U601" /idTUdmin="U601" /TUdmin="-3542" /isTUend="FALSE" /label="downshifts" downshifts complement(760862) /Source="Nicolas_upshifts" /id="D391" /incds=0 /nref=22 /ntot=199 /MaxReadThrough="1.59285" /MaxDrop="3.61098" /score="31.1923457" /energy="-11.1" /TU="NA" /idTUdmin="U602" /TUdmin=10 /isTUend="TRUE" /label="downshifts" S_feature 760863..762513 /Source="Nicolas_S_feature" /locus_tag="new_860294_861944" /HighExp="Etha, S6, S8, S5, S7, Gly, Salt, LoTm, S4, Diami" /AntisenseName="yfkL" /AntisenseCor="-0.52109661167911703" /AntisenseRegPval="-19.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S273" CDS complement(760872..762062) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16828913, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter" /protein_id="NP_388667.1" /db_xref="EnsemblGenomes-Gn:BSU07860" /db_xref="EnsemblGenomes-Tr:CAB12615" /db_xref="GOA:O34597" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12928" /db_xref="UniProtKB/Swiss-Prot:O34597" /translation="MQTTSIKTASGMYINYFFLGMVNIILASNMSSLTKQWNTDPTGI SYVIAAIGFGKLLTYGISGVLSDKIGRKPLVVASAGIMAVFLVGIPLSPSYELAFVFA LLAGVANSAMDAGTYPALTELFPSASGSANVLVKAFMSVGAALLPLLITFLADHSMFY GFAFYLPAAVYLLNIIYLSTLSFPKKHKKPTNSGQQESPVFLSEPVFQKEGTALIIIG FTSTALFTVSQIWLPSYAQKAAGLAESASVQLLSYYSIGSLASVLLLAVLLNRWVKPV FITLLYPIITLCTLAVMLTVHIPVVLDITAFFLGFSTAGVFQITITLMTELFWKRKGT VTGIVATASSLASILLPIATGLIAKAGGIAHIFIFDFGIAVIGTAAAAFLYYRYKKLT GAQA*" /label="yfkL CDS" gene complement(760872..762062) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /label="yfkL gene" S_feature complement(762063..762154) /Source="Nicolas_S_feature" /locus_tag="new_861494_861585_c" /HighExp="C90, MG 10, BMM, MG-0.2, MG t5, MG 5, MG-0.1, UNK1, HPh, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S274" CDS complement(762155..762370) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388668.1" /db_xref="EnsemblGenomes-Gn:BSU07870" /db_xref="EnsemblGenomes-Tr:CAB12616" /db_xref="InterPro:IPR009507" /db_xref="SubtiList:BG12927" /db_xref="UniProtKB/Swiss-Prot:O35019" /translation="MSSPNTETLTQMIEEISQKLNMLNVGVIKAEDFSDEKIEDLTYL HRMVMKKESFSPSEMQAIAQELASLRK*" /label="yfkK CDS" gene complement(762155..762370) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /label="yfkK gene" downshifts complement(762214) /Source="Nicolas_upshifts" /id="D392" /incds=0 /nref=1 /ntot=131 /MaxReadThrough="3.65318" /MaxDrop="2.45155" /score="16.183887" /energy="-11.6" /TU="U602" /idTUdmin="U602" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(762402..762421) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(762416) /Source="Nicolas_upshifts" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(762436..762437) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 762483..762490 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 762505..762524 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 762515 /Source="Nicolas_upshifts" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 762573..763043 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /EC_number="3.1.3.48" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-tyrosine-phosphatase" /protein_id="NP_388669.1" /db_xref="EnsemblGenomes-Gn:BSU07880" /db_xref="EnsemblGenomes-Tr:CAB12617" /db_xref="GOA:O35016" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:4ETM" /db_xref="SubtiList:BG12926" /db_xref="UniProtKB/Swiss-Prot:O35016" /translation="MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGG WHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGF KNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL*" /label="yfkJ CDS" gene 762573..763043 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /label="yfkJ gene" CDS 763061..763381 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388670.1" /db_xref="EnsemblGenomes-Gn:BSU07890" /db_xref="EnsemblGenomes-Tr:CAB12618" /db_xref="SubtiList:BG12925" /db_xref="UniProtKB/Swiss-Prot:O34418" /translation="MNNERLMLKGIFLGAAAGAALSLLHKPTRQACGMRWLTCKHKLS LYKSNPELLKNTVITKVDEAKKLARTLSKEVDFVNQQVKELKKTTPQVMELVQETKEH FSKK*" /label="yfkI CDS" gene 763061..763381 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /label="yfkI gene" CDS 763405..764232 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222749, 12794188, 15849754, 16850406, 15764599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease BN" /protein_id="NP_388671.1" /db_xref="EnsemblGenomes-Gn:BSU07900" /db_xref="EnsemblGenomes-Tr:CAB12619" /db_xref="GOA:O34437" /db_xref="InterPro:IPR017039" /db_xref="SubtiList:BG12924" /db_xref="UniProtKB/Swiss-Prot:O34437" /translation="MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAY LPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAI VRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGAS DLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLF SFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH* " /label="rbn CDS" gene 763405..764232 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /label="rbn gene" promotor_-35 764211..764217 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 764232..764243 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 764250..764406 /Source="Nicolas_S_feature" /locus_tag="new_863681_863837" /HighExp="S8, Etha, S6, Salt, S7, S5, ferm, nit, BT, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99976299999999996" /TUshortSig="SigGF, SigA, SigB" /TUshortPSig="0.974, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S275" upshifts 764250 /Source="Nicolas_upshifts" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(764282) /Source="Nicolas_upshifts" /id="D393" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.22239" /MaxDrop="3.61507" /score="-5.45682213" /energy="-3" /TU="NA" /idTUdmin="U606" /TUdmin=440 /isTUend="FALSE" /label="downshifts" downshifts 764381 /Source="Nicolas_upshifts" /id="D394" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="1.4253" /MaxDrop="6.85849" /score="25.8200126" /energy="-17.9" /TU="NA" /idTUdmin="U603" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(764431..765606) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388672.1" /db_xref="EnsemblGenomes-Gn:BSU07910" /db_xref="EnsemblGenomes-Tr:CAB12620" /db_xref="GOA:O34929" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12923" /db_xref="UniProtKB/Swiss-Prot:O34929" /translation="MSRFHFFILVLLVSISGFSQGMLLPVISIIFETNGESAAINGLH ATGLYIGVLLASPFMEAPLRKLGFKPLIVMGGSIVILSLFGFIWLQSVWVWFLLRLFI GIGDHMLHFSTQTWVTSMSSKQNRGRNLSIYGLSFGLGFAAGPFMVPLVKLSPSLPFI VSGCISLFAWLFVFFLQNAYPETSPHETKSDNSFRRFYQAMLFGWVAFMPTFGYGFLE TALNGSFPVYALRLGISVDAVAIILPAFAIGSIIFQFPLGILSDKYGRRNVLLVILLT GALCFFIAGVFPSPYVIGGCFFIAGMAVGSTFTLGISYMTDLLPPHLLPAGNLLCGIT FSLGSILGPVAGGWYMQTFESANLFYFITLTLSSVWLALVLGKPKSWSPAETYSSSS* " /label="yfkF CDS" gene complement(764431..765606) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /label="yfkF gene" downshifts complement(764436) /Source="Nicolas_upshifts" /id="D395" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="0.37084" /MaxDrop="3.28031" /score="3.2266059" /energy="-14.1" /TU="NA" /idTUdmin="U606" /TUdmin=286 /isTUend="FALSE" /label="downshifts" promotor_-35 765043..765049 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 765065..765083 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 765069..765722 /Source="Nicolas_S_feature" /locus_tag="new_864500_865153" /HighExp="Etha, M9-stat, Salt, Sw, Gly, B60, Heat, LPhT, HiTm, T0.30H" /AntisenseName="yfkF" /AntisenseCor="-0.18505347560608301" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S276" upshifts 765069 /Source="Nicolas_upshifts" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(765631..765650) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(765646) /Source="Nicolas_upshifts" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(765664..765671) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 765712..765717 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 765724 /Source="Nicolas_upshifts" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 765732..765750 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 765774..766829 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19543710, 23798403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19543710, 23798403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+/Ca2+ antiporter" /protein_id="NP_388673.1" /db_xref="EnsemblGenomes-Gn:BSU07920" /db_xref="EnsemblGenomes-Tr:CAB12621" /db_xref="GOA:O34840" /db_xref="InterPro:IPR004713" /db_xref="InterPro:IPR004798" /db_xref="InterPro:IPR004837" /db_xref="PDB:4KJR" /db_xref="PDB:4KJS" /db_xref="SubtiList:BG12922" /db_xref="UniProtKB/Swiss-Prot:O34840" /translation="MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM GRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLL VAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSI GISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVA YISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAV GSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG ATLLAAYVIMAIGFFLL*" /label="chaA CDS" gene 765774..766829 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /label="chaA gene" promotor_-35 766843..766849 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 766864..766875 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 766868 /Source="Nicolas_upshifts" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="upshifts" CDS 766900..767694 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19543710" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388674.1" /db_xref="EnsemblGenomes-Gn:BSU07930" /db_xref="EnsemblGenomes-Tr:CAB12622" /db_xref="InterPro:IPR025548" /db_xref="SubtiList:BG12921" /db_xref="UniProtKB/Swiss-Prot:O34579" /translation="MMKKLFHSTLIVLLFFSFFGVQPIHAKKQFKVPNSVASISKENT YPNASQDQPMLQPSKLAKELLDHSEVKIENPHLIKMLNESNISGTPLAVGYRATIFLG KWALGYESNETVANWEYKKINTNRADNRGGKETAEMHYAQEQQYRVKGGLTAKVPNAE DVKSMMMQKAMKKTNLPLAFETVIGAGTKRDQIYKVAPKKIGYLHAYAPAVNEKGKVT YGEVYLVLKGNKRKLVVKNVTSQGIGAWIPVQDHVTFGFQLSSLPR*" /label="yfkD CDS" gene 766900..767694 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /label="yfkD gene" downshifts 767682 /Source="Nicolas_upshifts" /id="D396" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="0.82657" /MaxDrop="5.7252" /score="28.7014976" /energy="-9.5" /TU="NA" /idTUdmin="U605" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(767733..768575) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17665170, 18310427, 19252899; Product type t: transporter" /codon_start=1 /transl_table=11 /product="mechanosensitive ion channel" /protein_id="NP_388675.1" /db_xref="EnsemblGenomes-Gn:BSU07940" /db_xref="EnsemblGenomes-Tr:CAB12623" /db_xref="GOA:O35043" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="SubtiList:BG12920" /db_xref="UniProtKB/Swiss-Prot:O35043" /translation="MRMKETLTEIFQNKIVDILLVAVILWIGVFIINRLVQLFFKRTD FIEEKKEKTIESLVRSVTQYTATIGFIFYVISLFVHDFGKILAGAGVAGIVIGFGAQS LIKDVLAGVFLIYERQLHKGDYVTVNNLFNGTVEEIGLRSLQIREWSGKLLTISNGEV RQIENYNIDFMRITESFLISFKEDPDRVYSVLEEACDMLNEELRDSLKRDEFGNPTEP FQIHGITALNKINRGVEFTVKGMVKDDDYFSASLAVRRVLVRQLYQNNVQMLEEAVRI ERTQ*" /label="mscC CDS" gene complement(767733..768575) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /label="mscC gene" downshifts complement(767735) /Source="Nicolas_upshifts" /id="D397" /incds=0 /nref=58 /ntot=230 /MaxReadThrough="1.96922" /MaxDrop="4.8789" /score="23.5281308" /energy="-9.8" /TU="NA" /idTUdmin="U609" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(768576..769697) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative Fe-S oxidoreductase, radical SAM superfamily" /protein_id="NP_388677.2" /db_xref="EnsemblGenomes-Gn:BSU07955" /db_xref="EnsemblGenomes-Tr:CAB12625" /db_xref="GOA:O34400" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014866" /db_xref="InterPro:IPR031004" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG12918" /db_xref="UniProtKB/Swiss-Prot:O34400" /translation="MTQNTKLRPITPEFDPWEAYMDVDQYGDMQLTNVEFTTTTLCNM RCEHCAVGYTLQPKDPNALPIDLLLKRLEEIPRLRSISITGGEPMLSLKSVKEYVVPL LKYAHERGVRTQINSNLTLDIERYEWIIPYLDVLHISHNWGTVEDFAEIGFAMMDRKP TFEQRARYFEKMIENSRTLVDAGVMVSAETMLNKRTLPHIEHIHRQITEDMKCQRHEV HPMYPSDFASALESLSLKEMRQAIHRLLDIRDENTWMLFGTLPFYACSPDEDDQKLLR RLRAAKNVTVRNDPDGRSRLNVNIFDGNIIVTDFGDTPPLGNIQTDSLPSAYEKWRET KLAKELSCHCPNVRCLGPNVLVKNSYYQDTDFTKRQARS*" /label="yfkA CDS" gene complement(768576..769697) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /label="yfkA gene" promotor_-10 complement(769738..769757) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(769756) /Source="Nicolas_upshifts" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(769773..769777) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 769785..769792 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 769806..769825 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 769816 /Source="Nicolas_upshifts" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="upshifts" CDS 769842..770027 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388678.1" /db_xref="EnsemblGenomes-Gn:BSU07970" /db_xref="EnsemblGenomes-Tr:CAB12626" /db_xref="SubtiList:BG12916" /db_xref="UniProtKB/Swiss-Prot:O35041" /translation="MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLIS MLDDLEAKYERFKKDWE*" /label="yfjT CDS" gene 769842..770027 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /label="yfjT gene" downshifts 770006 /Source="Nicolas_upshifts" /id="D398" /incds=0 /nref=15 /ntot=177 /MaxReadThrough="3.03457" /MaxDrop="3.24661" /score="14.1645187" /energy="-6.4" /TU="U610" /idTUdmin="U610" /TUdmin="-559" /isTUend="FALSE" /label="downshifts" promotor_-35 770070..770076 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 770082 /Source="Nicolas_upshifts" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 770091..770102 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 770128..770919 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported peptidoglycan N-acetylmuramic acid deacetylase" /protein_id="NP_388679.1" /db_xref="EnsemblGenomes-Gn:BSU07980" /db_xref="EnsemblGenomes-Tr:CAB12627" /db_xref="GOA:O34928" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014235" /db_xref="PDB:1NY1" /db_xref="PDB:1W17" /db_xref="PDB:1W1A" /db_xref="PDB:1W1B" /db_xref="SubtiList:BG12915" /db_xref="UniProtKB/Swiss-Prot:O34928" /translation="MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDA GKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGH FVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNL YLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAI YLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL*" /label="pdaA CDS" gene 770128..770919 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /label="pdaA gene" downshifts 770917 /Source="Nicolas_upshifts" /id="D399" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.12067" /MaxDrop="3.4013" /score="14.4741934" /energy="-10.2" /TU="NA" /idTUdmin="U611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(770957..771817) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative beta-hydroxyacid dehydrogenase" /protein_id="NP_388680.2" /db_xref="EnsemblGenomes-Gn:BSU07990" /db_xref="EnsemblGenomes-Tr:CAB12628" /db_xref="GOA:O34969" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12914" /db_xref="UniProtKB/Swiss-Prot:O34969" /translation="MKIAVIGLGNMGQPIARNVLQAGYELTVYNRTKQKTEDLVTEGA QAADTPRLAAKSADIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSE KLAAAHAEKGQFFLAAPVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDV GEESKTANAAKISINFLLVSMLEALSESFLMMEKYGLEQKQFLEIASALFGSPVYQNY GTIMAEQKFEPAGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDL DWAALIKCIK*" /label="yfjR CDS" gene complement(770957..771817) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /label="yfjR gene" downshifts complement(770971) /Source="Nicolas_upshifts" /id="D400" /incds=0 /nref=15 /ntot=193 /MaxReadThrough="2.61589" /MaxDrop="3.98341" /score="-1.3382901" /energy="-12.1" /TU="NA" /idTUdmin="U612" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(771837..771856) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(771851) /Source="Nicolas_upshifts" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(771872..771875) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(771916..772875) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563871, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="divalent cation (octahedral coordination) transporter" /protein_id="NP_388681.1" /db_xref="EnsemblGenomes-Gn:BSU08000" /db_xref="EnsemblGenomes-Tr:CAB12629" /db_xref="GOA:O31543" /db_xref="InterPro:IPR002523" /db_xref="InterPro:IPR004488" /db_xref="SubtiList:BG12913" /db_xref="UniProtKB/Swiss-Prot:O31543" /translation="MINITAITTEHQLLKNIPIERVEQPDIAWYWVDFYGPEDTETAL LRDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVIHALNKETLETEEVDIFQGEKFVV TFHLHETPGIAKVRERLYASPDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIE ESRPHKTYGTLMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDI YDHLLKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYG MNFDFMPELHWKYGYFAVLGLMAALVIGMLIWFVHKGWFNIFK*" /label="yfjQ CDS" gene complement(771916..772875) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /label="yfjQ gene" downshifts complement(771939) /Source="Nicolas_upshifts" /id="D401" /incds=0 /nref=137 /ntot=224 /MaxReadThrough="2.29296" /MaxDrop="4.2496" /score="10.2736001" /energy="-7.5" /TU="NA" /idTUdmin="U613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(772886..772905) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(772889) /Source="Nicolas_upshifts" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(772921..772924) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 772936..772940 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 772954..772973 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 772963 /Source="Nicolas_upshifts" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="upshifts" CDS 772994..773857 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA-3-methyladenine glycosylase" /protein_id="NP_388682.1" /db_xref="EnsemblGenomes-Gn:BSU08010" /db_xref="EnsemblGenomes-Tr:CAB12630" /db_xref="GOA:O31544" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG12912" /db_xref="UniProtKB/Swiss-Prot:O31544" /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQA GDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSA IFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKP ETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRG IGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLS YASLYLWRSIE*" /label="yfjP CDS" gene 772994..773857 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /label="yfjP gene" S_feature 773858..773970 /Source="Nicolas_S_feature" /locus_tag="new_873289_873401" /HighExp="BC, M40t90, LBGtran, C90, M9-stat, M0t90, Lbtran, Sw, M40t45, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S277" CDS 773971..775371 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methyltransferase" /protein_id="NP_388683.1" /db_xref="EnsemblGenomes-Gn:BSU08020" /db_xref="EnsemblGenomes-Tr:CAB12631" /db_xref="GOA:O31545" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12911" /db_xref="UniProtKB/Swiss-Prot:O31545" /translation="MNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPG ALPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQL REKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQSGSIIAGLYG LDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFET GEVQVVLVTAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKT VIQEVLGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMW VADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEHWLPKWTKEGFRPDVVI VDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQ TAHVEAVARLVLKSSN*" /label="yfjO CDS" gene 773971..775371 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /label="yfjO gene" downshifts 775383 /Source="Nicolas_upshifts" /id="D402" /incds=0 /nref=198 /ntot=251 /MaxReadThrough="1.18186" /MaxDrop="5.19313" /score="11.8630961" /energy="-12.6" /TU="NA" /idTUdmin="U614" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 775677..775684 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 775700..775719 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 775706 /Source="Nicolas_upshifts" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="upshifts" S_feature 775713..775996 /Source="Nicolas_S_feature" /locus_tag="new_875144_875427" /HighExp="M9-stat, T1.30H, T0.30H, T2.0H, LoTm, T3.0H, T3.30H, T1.0H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69102300000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S278" CDS 775997..776263 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097694.1" /db_xref="EnsemblGenomes-Gn:BSU08029" /db_xref="EnsemblGenomes-Tr:CAX52581" /db_xref="GOA:C0H3X6" /db_xref="InterPro:IPR025627" /db_xref="UniProtKB/Swiss-Prot:C0H3X6" /translation="MDKVYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMNGFPAN IVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN*" /label="yfzA CDS" gene 775997..776263 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /label="yfzA gene" promotor_-10 complement(776211..776230) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(776229) /Source="Nicolas_upshifts" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(776245..776248) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 776264..776745 /Source="Nicolas_S_feature" /locus_tag="new_875695_876176" /HighExp="G180, Paraq, H2O2, G135, Oxctl, G150, C30, LoTm, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S279" promotor_-35 776716..776719 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 776736..776755 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 776747..776994 /Source="Nicolas_S_feature" /locus_tag="new_876178_876425" /HighExp="H2O2, G180, Paraq, G150, G135, Oxctl, dia15, LBGstat, LBGexp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S280" upshifts 776747 /Source="Nicolas_upshifts" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 776995..777972 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /EC_number="1.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 25902496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase 2" /protein_id="NP_388684.1" /db_xref="EnsemblGenomes-Gn:BSU08030" /db_xref="EnsemblGenomes-Tr:CAB12632" /db_xref="GOA:O31546" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG12910" /db_xref="UniProtKB/Swiss-Prot:O31546" /translation="MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEF TNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDIN MGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTH ILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGL KLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPY KPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE*" /label="dusC CDS" gene 776995..777972 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /label="dusC gene" S_feature 777973..778065 /Source="Nicolas_S_feature" /locus_tag="new_877404_877496" /HighExp="G135, G180, Paraq, G150, H2O2, LBGexp, aero, dia0, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S281" downshifts 778022 /Source="Nicolas_upshifts" /id="D403" /incds=0 /nref=86 /ntot=218 /MaxReadThrough="3.30163" /MaxDrop="4.0519" /score="11.8630961" /energy="-12.6" /TU="U617" /idTUdmin="U618" /TUdmin="-1211" /isTUend="FALSE" /label="downshifts" promotor_-35 778106..778112 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 778124..778143 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 778133 /Source="Nicolas_upshifts" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 778168..778620 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388685.1" /db_xref="EnsemblGenomes-Gn:BSU08040" /db_xref="EnsemblGenomes-Tr:CAB12633" /db_xref="SubtiList:BG12909" /db_xref="UniProtKB/Swiss-Prot:O31547" /translation="MKRLCIIPCGKKKIWDVQPDAGPVRAEDAYLSPFHQACERYAKT FFDEWVILSAKHGFLRPDDLVSGNYDVTFGTGHPEIMTADELRRQFHEKGFSDIEELV MLGGKKYRSVLNAVIGEHQHISWPLSSYKGIGYMLQALNRAVEEKHEL*" /label="yfjM CDS" gene 778168..778620 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /label="yfjM gene" CDS 778650..779339 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388686.1" /db_xref="EnsemblGenomes-Gn:BSU08050" /db_xref="EnsemblGenomes-Tr:CAB12634" /db_xref="InterPro:IPR020523" /db_xref="SubtiList:BG11034" /db_xref="UniProtKB/Swiss-Prot:P40773" /translation="MKKLVFGLLAIVLFGCGLYIYHVWFGDPFSKNAAEQKLVSYVKQ TYPKKEIKITNGVYNAKTSEYVFEATSQSHRYPMCTKGFLHPKVTCDGIEEAYTESVA KHVNEEATKAIEADLKKAVPRFIKADAALSIENGQFTLDTKWNKKLAEKAPMSMTIQL DASGLSKTDAAKMAETVRKTLNEKGYTYSNGTIDCMQKDGDGGIGYVKYSIDFLSKAA IQSNDAEELGS*" /label="yfjL CDS" gene 778650..779339 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /label="yfjL gene" downshifts 779344 /Source="Nicolas_upshifts" /id="D404" /incds=0 /nref=31 /ntot=205 /MaxReadThrough="0.02745" /MaxDrop="3.61164" /score="23.9796437" /energy="-9" /TU="NA" /idTUdmin="U617" /TUdmin=1 /isTUend="TRUE" /label="downshifts" misc_feature 779516..779534 /Source="Nicolas_upshift_promotors" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 779523 /Source="Nicolas_upshifts" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 779571..780572 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109, 22714279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109, 22714279; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)" /protein_id="NP_388687.1" /db_xref="EnsemblGenomes-Gn:BSU08060" /db_xref="EnsemblGenomes-Tr:CAB12635" /db_xref="GOA:O31404" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12558" /db_xref="UniProtKB/Swiss-Prot:O31404" /translation="MKLLKREGLSLTEEKALWMYQKMLEIRGFEDKVHELFAQGVLPG FVHLYAGEEAVAVGVCAHLHDGDSITSTHRGHGHCIAKGCDLDGMMAEIFGKATGLCK GKGGSMHIADLDKGMLGANGIVGGGFTLACGSALTAKYKQTKNVSVCFFGDGANNQGT FHEGLNLAAVWNLPVVFVAENNGYGEATPFEYASACDSIADRAAAYNMPGVTVDGKDI LAVYQAAEEAIERARNGGGPSLIECMTYRNYGHFEGDAQTYKTKDERVEHLEEKDAIQ GFKNYLLKETDANKLSDIEQRVSESIEKAVSFSEDSPYPKDSELLTDVYVSYEKGGM* " /label="acoA CDS" gene 779571..780572 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /label="acoA gene" CDS 780576..781604 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 10368162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 10368162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent beta subunit)" /protein_id="NP_388688.1" /db_xref="EnsemblGenomes-Gn:BSU08070" /db_xref="EnsemblGenomes-Tr:CAB12636" /db_xref="GOA:O34591" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG12559" /db_xref="UniProtKB/Swiss-Prot:O34591" /translation="MARVISMSDAINEAMKLAMRKDENVLLIGEDVAGGAAVDHLQDD EAWGGVLGVTKGLVQEFGRTRVLDTPISEAGYMGAAMAAASTGLRPIAELMFNDFIGT CFDQVINQGAKFRYMFGGKAQVPITVRTTYGAGFRAAAQHSQSLYGLFTSIPGLKTVV PSNPYDAKGLLLAAIEDNDPVFFFEDKTSYNMKGEVPEDYYTIPLGKADIKREGNDVT LFAVGKQVNTALEAAAQLSERGIEAEVLDPRSLSPLDEDAIFTSLEKTNRLIIIDEAN PRCSIATDIAALVADKGFDLLDAPIKRITAPHTPVPFSPVLEDQYLPTPDKIVSVTLE LLGEPALN*" /label="acoB CDS" gene 780576..781604 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /label="acoB gene" CDS 781618..782814 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /EC_number="2.3.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase)" /protein_id="NP_388689.1" /db_xref="EnsemblGenomes-Gn:BSU08080" /db_xref="EnsemblGenomes-Tr:CAB12637" /db_xref="GOA:O31550" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG12560" /db_xref="UniProtKB/Swiss-Prot:O31550" /translation="MAVKVVMPKLGMAMKQGEVSIWNKKVGDPVEKGESIASIQSEKI EMEIEAPEKGTLIDIKVKEGEEVPPGTAICYIGDANESVQEEAGAPVAEDNMPQAVQP VKQENKPAASKKDRMKISPVARKIAEKAGLDLKQLKGTGPGGRIVKDDVTKALAEQKK DQAKPVSEQKAQEIPVTGMRKVIAARMQESLANSAQLTITMKADITKLATLQKQLSPT AEERYGTKLTITHFVSRAAVLALQAHPVLNSFYQNERIITHPHVHLGMAVALENGLVV PVIRHAEKLSLIELAQSISENAKKAREGRAGSEELQGSTFSITNLGAFGVEHFTPILN PPETGILGIGASYDTPVYQGEEIVRSTILPLSLTFDHRACDGAPAAAFLKAMKTYLEE PAALIL*" /label="acoC CDS" gene 781618..782814 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /label="acoC gene" downshifts complement(781619) /Source="Nicolas_upshifts" /id="D405" /incds=0 /nref=8 /ntot=46 /MaxReadThrough="0.481579999999999" /MaxDrop="4.16582" /score="-0.0231058321" /energy="-9.9" /TU="NA" /idTUdmin="U623" /TUdmin=4796 /isTUend="FALSE" /label="downshifts" CDS 782835..784211 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /EC_number="1.8.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase)" /protein_id="NP_388690.1" /db_xref="EnsemblGenomes-Gn:BSU08090" /db_xref="EnsemblGenomes-Tr:CAB12638" /db_xref="GOA:O34324" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12561" /db_xref="UniProtKB/Swiss-Prot:O34324" /translation="MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCI PTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKK NQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDS KDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQ EKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLE QAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKI NEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIM AEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLS TIGLAVHA*" /label="acoL CDS" gene 782835..784211 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /label="acoL gene" downshifts 784205 /Source="Nicolas_upshifts" /id="D406" /incds=0 /nref=27 /ntot=56 /MaxReadThrough="5.75671" /MaxDrop="5.6153" /score="27.0133719" /energy="-14.7" /TU="U619" /idTUdmin="U619" /TUdmin="-2156" /isTUend="FALSE" /label="downshifts" promotor_-35 784258..784265 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 784278..784297 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 784286 /Source="Nicolas_upshifts" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 784327..786144 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /experiment="publication(s) with functional evidences, PMID:11274109, 16944132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 16944132; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AcoR-acetoin)" /protein_id="NP_388691.1" /db_xref="EnsemblGenomes-Gn:BSU08100" /db_xref="EnsemblGenomes-Tr:CAB12639" /db_xref="GOA:O31551" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG11790" /db_xref="UniProtKB/Swiss-Prot:O31551" /translation="MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPY LEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALD GHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCS AAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRF GERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGG TCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAAR ALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTL FLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIR EDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNI RELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDM MIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES*" /label="acoR CDS" gene 784327..786144 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /label="acoR gene" promotor_-35 786145..786151 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 786163 /Source="Nicolas_upshifts" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 786166..786177 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 786198..786377 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_388692.1" /db_xref="EnsemblGenomes-Gn:BSU08110" /db_xref="EnsemblGenomes-Tr:CAB12640" /db_xref="GOA:O31552" /db_xref="InterPro:IPR012610" /db_xref="SubtiList:BG12917" /db_xref="UniProtKB/Swiss-Prot:O31552" /translation="MNIQRAKEIVESPDMKKVTYNGVPIYIQHVNEETGTARIYPLDE PQEEHEVQLNSLKED*" /label="sspH CDS" gene 786198..786377 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /label="sspH gene" downshifts 786361 /Source="Nicolas_upshifts" /id="D407" /incds=0 /nref=96 /ntot=181 /MaxReadThrough="1.9176" /MaxDrop="6.06509" /score="5.08326573" /energy="-12" /TU="NA" /idTUdmin="U619" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(786413..786742) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388693.1" /db_xref="EnsemblGenomes-Gn:BSU08120" /db_xref="EnsemblGenomes-Tr:CAB12641" /db_xref="GOA:O31553" /db_xref="InterPro:IPR003844" /db_xref="SubtiList:BG12908" /db_xref="UniProtKB/Swiss-Prot:O31553" /translation="MMLITILLFLAAGLAEIGGGYLVWLWLREAKPAGYGIAGALILI VYGILPTFQSFPSFGRVYAAYGGVFIVLAVLWGWLVDRKTPDLYDWIGAFICLIGVCV ILFAPRG*" /label="yfjF CDS" gene complement(786413..786742) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /label="yfjF gene" downshifts complement(786427) /Source="Nicolas_upshifts" /id="D408" /incds=0 /nref=96 /ntot=245 /MaxReadThrough="2.05328" /MaxDrop="6.2642" /score="34.1179702" /energy="-15.8" /TU="NA" /idTUdmin="U623" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(786792..787250) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388694.1" /db_xref="EnsemblGenomes-Gn:BSU08130" /db_xref="EnsemblGenomes-Tr:CAB12642" /db_xref="GOA:O31554" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12907" /db_xref="UniProtKB/Swiss-Prot:O31554" /translation="MSEALTFESKYALLYLGGGLLAMIYGLITFFMAFPAFTSRGNVI FTIKTGPSGEIFLRKRSVLFSEVKRLYMGRHQYSLKGIFFEDIIIEKTDGKIVRIPTW NIITNPLFFEAVERYILPHLNEEAQNNWISQFTEVQRKAYLKEFENHPKL*" /label="yfjE CDS" gene complement(786792..787250) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /label="yfjE gene" S_feature complement(787251..787343) /Source="Nicolas_S_feature" /locus_tag="new_886682_886774_c" /HighExp="BI, BC, S2, Sw, HiOs, HiTm, S5, ferm, S4, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S282" CDS complement(787344..787901) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388695.1" /db_xref="EnsemblGenomes-Gn:BSU08140" /db_xref="EnsemblGenomes-Tr:CAB12643" /db_xref="GOA:O31555" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12906" /db_xref="UniProtKB/Swiss-Prot:O31555" /translation="MKNQEIIEVKSKMFLRIWAFVGSAGMGLACLWLFYMGITFQTKY YLLAIPAGFLFTLFCLYLFIIFFPAFTPRGNTIFRIKTGKNGEVFTDKVSVTFTDIKK IEMSRHKFSLKGIFQEDILIQTVDQKTIRIPTWNIIPNPLFFEAVERYILPHLNEEAK SNWIGQFTDIQRSAYLKEFENHPKL*" /label="yfjD CDS" gene complement(787344..787901) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /label="yfjD gene" promotor_-35 787767..787772 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 787780 /Source="Nicolas_upshifts" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 787787..787805 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 787791..788378 /Source="Nicolas_S_feature" /locus_tag="new_887222_887809" /HighExp="S4, S5, S6, S3, S8, S7, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="yfjC" /AntisenseCor="9.3643586039105595E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S283" CDS complement(787933..788700) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388696.1" /db_xref="EnsemblGenomes-Gn:BSU08150" /db_xref="EnsemblGenomes-Tr:CAB12644" /db_xref="SubtiList:BG12905" /db_xref="UniProtKB/Swiss-Prot:O31556" /translation="MKQFTISIEELLFCFYSEGFFEQGMALKQAYFPEIEDEQLGALF EAACRSLLAKDAAEYRNHQYRLKDEYCPFIHVLNDADYTVKLSKFNGQGAEQNVSCHV SKFGTYSHELLFDEQVHRITKMESSEGLLAKTDEFLHIIDTEDKRESIVTLTSNEFEK LLEGASDNPSYLKEFLEKHDHQEDVTRFANDLALRKGKMDTLMRLAYGKDNTPEVADM AFVLPGAHHTWLVTGITQNEFSILPAHKDVVNQIISK*" /label="yfjC CDS" gene complement(787933..788700) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /label="yfjC gene" CDS complement(788712..789935) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388697.1" /db_xref="EnsemblGenomes-Gn:BSU08160" /db_xref="EnsemblGenomes-Tr:CAB12645" /db_xref="SubtiList:BG12904" /db_xref="UniProtKB/Swiss-Prot:O31557" /translation="MSGNIAVDPDKLEQLANDVVTELTDMENKYKDLHVELGQMILQC DPRYSSCFSGVGDAWSSGKALVTKLSDNEIFIRKTGDKFVEQDDILRKLYNAYDKYGT MTSLTALMLTQGKYYGLGLTKFVKQPSGLHTAQHSKLLLDISRAVDSSRYQKAARVLL NPKYLLKKTNRPFSDLVHKKFTKYFPQDTVDFSNSVRSYTKGFLNEAGVRSTLKDVGK TGLRFAKGNAITATLITGATETFGAGVKIAENYAKYQDKPEVLKRENAKAVGNAVNNT IFVAGGATAGAVIGGAIGSFAGPVGTVLLGAAGSYIGGVVGEQIAKYTAGFAEKAALK LKEPIHAVVDTAKKGLESAGKVVKSVNDGIDAANKSIHKGIDSAKKGMEKAKKTADSL IHGATHFLKGKFSFG*" /label="yfjB CDS" gene complement(788712..789935) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /label="yfjB gene" CDS complement(789941..790255) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388698.1" /db_xref="EnsemblGenomes-Gn:BSU08170" /db_xref="EnsemblGenomes-Tr:CAB12646" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12903" /db_xref="UniProtKB/Swiss-Prot:O31558" /translation="MDSYKVIELANKYSAAAEEVRSSKMLLESRLSALGDAWQGKARD SFDQDFEETKAAYDQFEQELLETSQELKAAAVKIEERKAEIARMEELERKAREERHKL GR*" /label="yfjA CDS" gene complement(789941..790255) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /label="yfjA gene" promotor_-10 complement(790303..790322) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(790316) /Source="Nicolas_upshifts" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(790337..790340) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 790547..790566 /Source="Nicolas_upshift_promotors" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 790550 /Source="Nicolas_upshifts" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="upshifts" CDS 790591..791940 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /EC_number="3.2.1.122" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-alpha-glucosidase" /protein_id="NP_388699.1" /db_xref="EnsemblGenomes-Gn:BSU08180" /db_xref="EnsemblGenomes-Tr:CAB12647" /db_xref="GOA:P54716" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:1U8X" /db_xref="SubtiList:BG11839" /db_xref="UniProtKB/Swiss-Prot:P54716" /translation="MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDK ERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIP LKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRR LRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLM PKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMV KKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYN TGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVE KLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS* " /label="malA CDS" gene 790591..791940 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /label="malA gene" misc_feature 791969..791988 /Source="Nicolas_upshift_promotors" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 791971 /Source="Nicolas_upshifts" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="upshifts" CDS 792005..792769 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489864, 16707683, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489864, 16707683, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the Mal operon" /protein_id="NP_388700.1" /db_xref="EnsemblGenomes-Gn:BSU08190" /db_xref="EnsemblGenomes-Tr:CAB12648" /db_xref="GOA:P54717" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11847" /db_xref="UniProtKB/Swiss-Prot:P54717" /translation="MQLEELINQHYSKLNDNDFHILKYILNHKHTCYHLGIDALAKAC SVSRSSILRLAQKLGFSGYSEFRVFLKWEDQPEEGESMSFEKLLDDIEANLKFLRTKD MTDMCQLIDAADRIFVYGSGNAQKICARDLQRMFIPRHRYLILIEDTNEFNLMRDDFK VNDLFIIISLSGETPELIPQARMLSAKGIPFISITNLKNNVLAQLTPHNLYATSKPVT LSDRTEIVAFAPFFLVGEALFRAYVDYKEAEKNDNE*" /label="malR CDS" gene 792005..792769 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /label="malR gene" promotor_-10 complement(792149..792163) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(792179..792185) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(792179) /Source="Nicolas_upshifts" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 792784..794367 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) maltose-specificenzyme IICB component" /protein_id="NP_388701.1" /db_xref="EnsemblGenomes-Gn:BSU08200" /db_xref="EnsemblGenomes-Tr:CAB12649" /db_xref="GOA:P54715" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010975" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11848" /db_xref="UniProtKB/Swiss-Prot:P54715" /translation="MMQKIQRFGSAMFVPVLLFAFAGIIVGISTLFKNKTLMGPLADP DGFWYQCWYIIEQGGWTVFNQMPLLFAIGIPVALAKKAQARACLEALTVYLTFNYFVS AILTVWGGAFGVDMNQEVGGTSGLTMIAGIKTLDTNIIGAIFISSIVVFLHNRYFDKK LPDFLGIFQGSTYIVMISFFIMIPIALAVSYIWPMVQSGIGSLQSFLVASGAVGVWIY TFLERILIPTGLHHFIYTPFIYGPAVAEGGIVTYWAQHLGEYSQSAKPLKELFPQGGF ALHGNSKIFGIPGIALAFYVTAKKEKKKLVAGLLIPVTLTAIVAGITEPIEFTFLFIS PFLFAVHAVLAATMSTVMYMAGVVGNMGGGLIEAVTLNWIPLFGSHGMTYVYQILIGL SFTAIYFFVFRFLILKFNIATPGREKDEQQETKLYSKKEYRERKNKDETASAAETADD TAFLYIEALGGKDNITEVTNCATRLRVSVKDETKVEPDSVFRALGAHGVVRNGKAFQV IIGLSVPQMRERVEKILNQ*" /label="malP CDS" gene 792784..794367 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /label="malP gene" downshifts 794347 /Source="Nicolas_upshifts" /id="D409" /incds=0 /nref=23 /ntot=46 /MaxReadThrough="3.26652" /MaxDrop="4.69656" /score="8.65399085" /energy="-10.9" /TU="U624" /idTUdmin="U625" /TUdmin=836 /isTUend="FALSE" /label="downshifts" promotor_-35 794396..794403 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 794418..794437 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 794426 /Source="Nicolas_upshifts" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="upshifts" CDS 794473..796194 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative xenobiotic ABC transporter subunit (ATP-binding protein)" /protein_id="NP_388702.1" /db_xref="EnsemblGenomes-Gn:BSU08210" /db_xref="EnsemblGenomes-Tr:CAB12650" /db_xref="GOA:P54718" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11849" /db_xref="UniProtKB/Swiss-Prot:P54718" /translation="MQKALSFLKPYSLLAGIALILMLTELAVELMQPLLIAKIIDDGI LKQDLRHVWIWGTVMIGLTVLSFAAGMLNSFYAAHVSQSFSYDTRKGLFQKIQSFSYS TFGQFSSSSYITRLTNDVTQVQNMIFMSLRFMLRAPLMIAGGIVLSLAVNVKLGFFLL VTIPILILFLLWVLRKGGALFRSVQKRLDQVNTIMQENLIAIKLIKALLRGSHEVKRF IKANTRLMEKTVSAFQLVEFTMPVLMLLMNLCILLILWAGSYSITSGSTQVGDVVAII NYATRITGALSMFPFLIMIFTRAKASGDRIGEVLETEGDEREEGTISDRLSGRIEFQH VSFRYPEMDREALRNVSFSAKPRETIAILGATGSGKSTLFQLIPRLYQPDSGRIYIDE KPVQDIPAEGLRRQIGYVPQEVLLFSGTIKENIAWGKENASLDEIMDAAKLAQIHETI LKLPNGYDTVLGQRGVNLSGGQKQRISIARALIRKPAILLLDDSTSALDLQTEAKLLE AISTYHCTTLIITQKITTAMKADQILLLEDGELIEKGTHSELLSESQLYKRIYESQFG REGSESC*" /label="yfiB CDS" gene 794473..796194 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /label="yfiB gene" CDS 796188..798002 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388703.1" /db_xref="EnsemblGenomes-Gn:BSU08220" /db_xref="EnsemblGenomes-Tr:CAB12651" /db_xref="GOA:P54719" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11850" /db_xref="UniProtKB/Swiss-Prot:P54719" /translation="MLKDIRKPFQYPKLPIDKKEGAKKRAKAKDTKGTLRRIWSYLAE RKGLLILVMLMVVISAIFGLLGPFVIGKAIDHFIVGKTVSGLIPVLLLLLAIYIIQSL SLWFQNYWMITISQGTVFRMRSELFTHLHELPIPFFDKQRHGELMSRVTNDIENVSST LNTSVIQILSSVITFVGTIAVMLYMSPLLTLITLTIIPVMAASLKWITNRTGKLFKEQ QKNLGDLNGYIEESVSGAKVIKAYSREKQITAEFLEKNAALKTSGFWAQTISGFIPKV MNSLNNLSFTMIAAIGGLFALKGWISIGSIVVFAEYSRQFTRPLNDLANQFNTMLSAI AGAERVFDVLDEKEEREDEKNAVHQPIQTGSIEFRDVSFGYDKGQQTLKHLQFTVPAG QSIAFVGPTGAGKTTVTNLLARFYEPNDGKILIDGTDIKTLTRASLRKNMGFVLQDSF LFQGTIRENIRYGRLDASDQEVEAAAKTANAHSFIERLPKGYDTVLTQNGSGISQGQK QLISIARAVLADPVLLILDEATSNIDTVTEVNIQEALARLMEGRTSVIIAHRLNTIQR ADQIVVLKNGEMIEKGSHDELIRQKGFYSDLYESQFEK*" /label="yfiC CDS" gene 796188..798002 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /label="yfiC gene" downshifts 797977 /Source="Nicolas_upshifts" /id="D410" /incds=0 /nref=103 /ntot=190 /MaxReadThrough="2.4559" /MaxDrop="5.61906" /score="24.4395842" /energy="-11" /TU="NA" /idTUdmin="U627" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 798084..798091 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 798105..798124 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 798109 /Source="Nicolas_upshifts" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="upshifts" CDS 798157..798561 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16872404, 16850406, 17407181, 20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16872404, 16850406, 17407181, 20639328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase membrane subunit" /protein_id="NP_388704.1" /db_xref="EnsemblGenomes-Gn:BSU08230" /db_xref="EnsemblGenomes-Tr:CAB12652" /db_xref="GOA:P54720" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG11851" /db_xref="UniProtKB/Swiss-Prot:P54720" /translation="MNKSFEIGTLLLRVITGIIFFVHGLSKFQGMEGTIQFFGSIGLP SFMAYVIAAIELIGGVLVFFGLATRIVGVLFALTLIGAIITVKLKAPFMGNAEFDYLL LLTSIHLALTGSRFLALDPFVFKGKKNGNVSA*" /label="catD CDS" gene 798157..798561 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /label="catD gene" CDS 798579..799436 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17407181, 16872404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 16872404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase subunit" /protein_id="NP_388705.2" /db_xref="EnsemblGenomes-Gn:BSU08240" /db_xref="EnsemblGenomes-Tr:CAB12653" /db_xref="GOA:P54721" /db_xref="InterPro:IPR000486" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11852" /db_xref="UniProtKB/Swiss-Prot:P54721" /translation="MTSIHEDTHIGYAKLTIRSLERSLQFYCNVIGFQVLKKTDRQAE LTADGKRVLLILEENPSAVVLPERSVTGLYHFAILLPDRKELGIALARLIEHGIAIGH GDHAVSEALYLSDPDGNGIEMYADRPRSTWQRDREGNYVMTTTAVDIEGLLEEAGDER KTSLPNDTIIGHIHLHVSDLKEAKAFYTDVLGFDIVGNYAGMSALFVSAGGYHHHIGL NIWAGRNAPPKPTNASGLDYYTVVLPHQEELDLVANRVKHAGYSIEETENSFRVKDPV SGAYITFVI*" /label="catE CDS" gene 798579..799436 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /label="catE gene" downshifts 799423 /Source="Nicolas_upshifts" /id="D411" /incds=0 /nref=4 /ntot=21 /MaxReadThrough="0.66359" /MaxDrop="3.74886" /score="50.8573531" /energy="-19.7" /TU="NA" /idTUdmin="U628" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS 799530..800474 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family; cupin family)" /protein_id="NP_388706.1" /db_xref="EnsemblGenomes-Gn:BSU08250" /db_xref="EnsemblGenomes-Tr:CAB12654" /db_xref="GOA:P54722" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11853" /db_xref="UniProtKB/Swiss-Prot:P54722" /translation="MELNHLVTGKIALNQYVHRLEQKDVSFYVHYWGAMTNHYNTLLH KHSFYEICYVVRGEGYYLEGDRTYPLREQTIFLSKPEHLHQIKSETGLFLFYVAFELS EDQSSAEWIKVMEEVKQSPFITMQLKDGEPPGLLWKTLMLQAAQPVNAFDKEILSHLS HALILSLIQTFLPYAQRPKQKQPIHTSSALLTEVKLHIKDNLSQPLKLTDVASHFHIS GRHLSRLFAAELGVSYSEFVQNEKINKAAELLKSTNLSIKEIAEEIGFSVHYFTRVFS AKIGSSPGLFRSLYKDSKMTAFQINKPFQKIEQAKPHE*" /label="yfiF CDS" gene 799530..800474 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /label="yfiF gene" downshifts complement(800341) /Source="Nicolas_upshifts" /id="D412" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="-0.20031" /MaxDrop="3.51831" /score="-4.19869956" /energy="-9.5" /TU="NA" /idTUdmin="U632" /TUdmin=9372 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(800389..800489) /Source="Nicolas_upshift_promotors" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(800429) /Source="Nicolas_upshifts" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 800649..802097 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar/proton transporter" /protein_id="NP_388707.1" /db_xref="EnsemblGenomes-Gn:BSU08260" /db_xref="EnsemblGenomes-Tr:CAB12655" /db_xref="GOA:P54723" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11854" /db_xref="UniProtKB/Swiss-Prot:P54723" /translation="MSTKKKEAVIGKESLAHKGLLRTITLVSTFGGLLFGYDTGVING ALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLSDRHGRRKTILYLALLFIA ATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVI GQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIVPESPRWLAAKGRMG DALRVLRQIREDSQAQQEIKEIKHAIEGTAKKAGFHDFQEPWIRRILFIGIGIAIVQQ ITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLII GQIGTMTALLLIGILSIVLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPM HVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAILFVKKYVPE TKGRSLEQLEHSFRQYGRRADQEIQNQTTHLS*" /label="yfiG CDS" gene 800649..802097 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /label="yfiG gene" CDS 802124..803065 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_388708.1" /db_xref="EnsemblGenomes-Gn:BSU08270" /db_xref="EnsemblGenomes-Tr:CAB12656" /db_xref="InterPro:IPR011418" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11855" /db_xref="UniProtKB/Swiss-Prot:P54724" /translation="MKLSYVTDSLGHLPFEDMLNFAAKLGIDTLEMTTGGWSPAPHLN LDELLQSSEKRKEFSQALEKRNMTLCALNCSGNPLDPGELGKSHRDITDKTMELAGLL GVKKVIMMSGLPAGGPDDKVPNWITYTVSWPPVLKDILNYQWEDVAIPYWKKLVKKAE ACGVGKIALENFSSQLVYNPETLFRLRNAVGPMVGLNLDPSHLLWMGADPIIAARELG SAIHHVHGKDVRIERYLSAVNGLLETKEVTDPANRAWNYVAVGCGQDLQWWKEFFSVV KMMGYEGEVSLEMEDLTMSPEAGIRTSVEALKQTISQ*" /label="yfiH CDS" gene 802124..803065 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /label="yfiH gene" CDS 803075..804256 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26438878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388709.1" /db_xref="EnsemblGenomes-Gn:BSU08280" /db_xref="EnsemblGenomes-Tr:CAB12657" /db_xref="GOA:P94437" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12214" /db_xref="UniProtKB/Swiss-Prot:P94437" /translation="MMLNGERIISKPLRWAMVGGGRLSQVGYKHRIGALRDNTAFQLT AGAFDIDAERGKDFGVNLGVDAERCYPNYQTMFAEEAKRQDGIEVVSIATPNGTHYEI CKAALEAGVHVICEKPLFFTSAEGQEIKALAEKKGKIVGVTYGFSGNQMLLQMRAMIE QGMIGDIRVVDLQYTHGFCATDEGEKISAAQKWRVDPAIAGPSFVLGDLSTHTYYMSQ LIMPKMKIKELLCDRQSFVGSRAPLEDNAHVLMHYENGAVGTMWTSSINAGCMDGHRI RIVGSKASIEWWDSKPNELTYEVQGEPGQTLVRGMPYLDDVCNADERLGALHSEGLSE AWANIYLKFAIAIDAKNREDEEILNNLVYPDIDAGIEGIRWIENCVRSANQGSVWVEF K*" /label="yfiI CDS" gene 803075..804256 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /label="yfiI gene" downshifts 804246 /Source="Nicolas_upshifts" /id="D413" /incds=0 /nref=40 /ntot=113 /MaxReadThrough="0.88387" /MaxDrop="5.80704" /score="14.819468" /energy="-13" /TU="NA" /idTUdmin="U630" /TUdmin="-2003" /isTUend="FALSE" /label="downshifts" promotor_-35 804316..804322 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 804337..804356 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 804355 /Source="Nicolas_upshifts" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="upshifts" CDS 804380..805582 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /function="16.12: Sense" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LinK] (linearmycin resistance, biofilm formation)" /protein_id="NP_388710.1" /db_xref="EnsemblGenomes-Gn:BSU08290" /db_xref="EnsemblGenomes-Tr:CAB12658" /db_xref="GOA:P94438" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12215" /db_xref="UniProtKB/Swiss-Prot:P94438" /translation="MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAAN HVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSV LCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQF QELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLL REWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKN AGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLV IKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGP VQQKESLS*" /label="linJ CDS" gene 804380..805582 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /label="linJ gene" CDS 805579..806241 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LinJ] (linearmycin resistance, biofilm formation)" /protein_id="NP_388711.1" /db_xref="EnsemblGenomes-Gn:BSU08300" /db_xref="EnsemblGenomes-Tr:CAB12659" /db_xref="GOA:P94439" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12216" /db_xref="UniProtKB/Swiss-Prot:P94439" /translation="MIKIIITDDQDIVREGLASLLQLREELDVIATARNGQEAFEKAK ELEPDIVLMDIRMPVSNGVEGTKLITSSLPSVKVLMLTTFKDSALIAEALEEGASGYL LKDMSADTIVKAVMTVHSGGMVLPPELTAQMLNEWKREKQLKGINEIEKPNELLDLTE REIEVLAELGYGLNNKEIAEKLYITEGTVKNHVSNIISKLAVRDRTQAAIYSVRYGVS VF*" /label="linK CDS" gene 805579..806241 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /label="linK gene" downshifts 806249 /Source="Nicolas_upshifts" /id="D414" /incds=0 /nref=114 /ntot=229 /MaxReadThrough="-0.0105699999999995" /MaxDrop="4.23231" /score="20.4785449" /energy="-7.6" /TU="NA" /idTUdmin="U630" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 806385..807320 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) biofilm formation" /protein_id="NP_388712.2" /db_xref="EnsemblGenomes-Gn:BSU08310" /db_xref="EnsemblGenomes-Tr:CAB12660" /db_xref="GOA:P94440" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12217" /db_xref="UniProtKB/Swiss-Prot:P94440" /translation="MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTI SMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMY GLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPT VGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTD LCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSL LAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD*" /label="bifL CDS" gene 806385..807320 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /label="bifL gene" CDS 807333..808523 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388713.1" /db_xref="EnsemblGenomes-Gn:BSU08320" /db_xref="EnsemblGenomes-Tr:CAB12661" /db_xref="GOA:P94441" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12218" /db_xref="UniProtKB/Swiss-Prot:P94441" /translation="MKKSIWIAWKDVKIRITDRKGFMMLILMPLILTCILGAALGSVV DGGSRIDDIKVGYIQSDQSDTANMFTKDVLKKMKSIKVTKVGSKDKMKKLIDEKKIDV GIVIPNHWEAGKTSAVVNAAPDQTLKSSIIETAASSFIEQYKAVKEAASGSMDYISKT EAVKQGKLDPAQFAEKLAKTLEKETGDKLTIAEKSVGSKAVTSFQYYSAAMLCMFMLF HITVGAKSFLQEKDTETLARMLMTPAQKSVILFGKWLGTYLFAIIQFFIFLIVTINVF GVDWGGNLLLVSVLGLSYAAAVSGISMLLASCISDMKTADAIGGFGIQLLAVLGGSML PLYQFPDVLQSVSKAVPNRWALDGFLSLMEGGGWADLQKPVLLFAAIGFCSLVIGIRR LHTR*" /label="bifM CDS" gene 807333..808523 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /label="bifM gene" CDS 808537..809694 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388714.1" /db_xref="EnsemblGenomes-Gn:BSU08330" /db_xref="EnsemblGenomes-Tr:CAB12662" /db_xref="GOA:P94442" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12219" /db_xref="UniProtKB/Swiss-Prot:P94442" /translation="MKKILAICGIELSLIFKKPQNYLIMFAAPLLLTFVFGSMLSGND DKVRLAIVDQDDTILSQHYIRQLKAHDDMYVFENMSESKASEKLKQKKIAGIIVISRS FQTQLEKGKHPELIFRHGPELSEAPMVKQYAESALATLNIQVTAAKTASQTAGENWKA AYKTVFAKKHEDIVPAVTRQTLSDKKEGAEASDTASRAAGFSILFVMLTMMGAAGTIL EARKNGVWSRLLTASVSRAEIGAGYVLSFFVIGWIQFGILLLSTHWLFGINWGNPAAV IVLVSLFLLTVVGIGLMIAANVRTPEQQLAFGNLFVIATCMVSGMYWPIDIEPKFMQS IAEFLPQKWAMSGLTEIIANGARVTDILGICGILLAFAAITFAAGLKALRA*" /label="bifN CDS" gene 808537..809694 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /label="bifN gene" promotor_-35 808648..808653 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 808668..808686 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 808669 /Source="Nicolas_upshifts" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(809692..809766) /Source="Nicolas_S_feature" /locus_tag="new_909123_909197_c" /HighExp="LoTm, Sw, C90, HiOs, BC, MG 45, UNK1, Fru, S1, BI" /AntisenseName="yfiN" /AntisenseCor="-6.3486715356968801E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S284" downshifts complement(809735) /Source="Nicolas_upshifts" /id="D415" /incds=0 /nref=90 /ntot=257 /MaxReadThrough="1.41433" /MaxDrop="6.01369" /score="13.7314837" /energy="-11.5" /TU="U632" /idTUdmin="U632" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(809767..810315) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of phenolic acid decarboxylase" /protein_id="NP_388715.1" /db_xref="EnsemblGenomes-Gn:BSU08340" /db_xref="EnsemblGenomes-Tr:CAB12663" /db_xref="GOA:P94443" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR018309" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12220" /db_xref="UniProtKB/Swiss-Prot:P94443" /translation="MRVLKYAILGLLRKGELSGYDITSYFKEELGQFWSAKHSQIYPE LKKLTDEGFITFRTTIQGTKLEKKMYTLTDSGKQELHDWLIRHQPIPETVKDEFMLKA YFISCLSRQEASDLFKDQLQKRQAKLSDLQGSYEKLMASAEPMSFSSPDFGHYLVLTK ALEREKNYVSWLESILAMIDKD*" /label="padR CDS" gene complement(809767..810315) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /label="padR gene" S_feature complement(810316..810395) /Source="Nicolas_S_feature" /locus_tag="new_909747_909826_c" /HighExp="LoTm, Cold, G180, GM-0.2, Oxctl, T5.0H, GM 25, T3.30H, MG 60, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S285" promotor_-10 complement(810384..810403) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(810395) /Source="Nicolas_upshifts" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(810417..810422) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 810518..810521 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 810537..810556 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 810544 /Source="Nicolas_upshifts" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="upshifts" CDS 810588..811220 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11029590, 10913700, 21574267" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11029590, 10913700, 21574267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted esterase / acylglycerol lipase" /protein_id="NP_388716.1" /db_xref="EnsemblGenomes-Gn:BSU08350" /db_xref="EnsemblGenomes-Tr:CAB12664" /db_xref="GOA:Q79F14" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11951" /db_xref="UniProtKB/Swiss-Prot:Q79F14" /translation="MKKVLMAFIICLSLILSVLAAPPSGAKAESVHNPVVLVHGISGA SYNFFAIKNYLISQGWQSNKLYAIDFYDKTGNNLNNGPQLASYVDRVLKETGAKKVDI VAHSMGGANTLYYIKYLGGGNKIQNVVTLGGANGLVSSTALPGTDPNQKILYTSIYSL NDQIVINSLSRLQGARNIQLYGIGHIGLLSNSQVNGYIKEGLNGGGLNTN*" /label="estB CDS" gene 810588..811220 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /label="estB gene" downshifts 811199 /Source="Nicolas_upshifts" /id="D416" /incds=0 /nref=7 /ntot=100 /MaxReadThrough="0.87881" /MaxDrop="2.6151" /score="0.223019698" /energy="-8.5" /TU="NA" /idTUdmin="U633" /TUdmin=88 /isTUend="FALSE" /label="downshifts" promotor_-35 811335..811340 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 811354..811373 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 811364 /Source="Nicolas_upshifts" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="upshifts" CDS 811409..812497 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 24776724, 25935415, 27303652; Product type t : transporter" /codon_start=1 /transl_table=11 /product="acetyl-glucosamine metabolite exporter componentinvolved in biofilm formation" /protein_id="NP_388717.1" /db_xref="EnsemblGenomes-Gn:BSU08360" /db_xref="EnsemblGenomes-Tr:CAB12665" /db_xref="GOA:O31559" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG12893" /db_xref="UniProtKB/Swiss-Prot:O31559" /translation="MQIKEIFMIRCISCLSVVLLHIISMVLMLQAEALADISHTVDSF RTLLMFSTPAFIFISEFLLARSYPDGVPDGFLKKRGKVIFVPFLFIAAIDALLMTSAM GGEVTFLAFVQKYLANVFLGNFIGYFILVIFQFYMLHMMFHEYLKKASPKWVLSISFV VTAAYLGYFSAASPAPASEEGGAFPFFWVPFAGWLFYFCLAYYCGKEYKRFLALLNQY RWVVYGAAIASGALVVTVSYVGEIGMISSKRPDIMLYSTSMIFLCFHLFSKMKHVPKI MMFISNYSFSIYLLHAYFMIIGYVLLLNMPEIPAVPAVLLLFAVCTAGPIMTSWALNK FKYGYLFVGKIYQPKQKKVTVEVRDHAG*" /label="icaC CDS" gene 811409..812497 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /label="icaC gene" S_feature complement(811899..812287) /Source="Nicolas_S_feature" /locus_tag="new_911330_911718_c" /HighExp="S6, S8, S7, S5, LBGstat, H2O2, Mt0, Cold, G180, LPhT" /AntisenseName="yfiQ" /AntisenseCor="0.36913176163336098" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S286" upshifts complement(812287) /Source="Nicolas_upshifts" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(812289..812308) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(812321..812329) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(812533..813150) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16862575" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16862575; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388718.1" /db_xref="EnsemblGenomes-Gn:BSU08370" /db_xref="EnsemblGenomes-Tr:CAB12666" /db_xref="GOA:O31560" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1RKT" /db_xref="SubtiList:BG12894" /db_xref="UniProtKB/Swiss-Prot:O31560" /translation="MSPKVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGF SRGGVYLYFSSTEEMFRRIIETGLDEGLRKLDKSAEHQSVWASISSYLDELTEGLRDV ADTLAPVQFEYLVTAWRNEERRQYLEKRYDLFVERFSRLLQKGIDQGEFQPVQPLATI AKFFLNMNDGIIQNALYFDEEKADVSGLAESAKLYLKTVLQADEK*" /label="yfiR CDS" gene complement(812533..813150) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /label="yfiR gene" downshifts complement(812551) /Source="Nicolas_upshifts" /id="D417" /incds=0 /nref=29 /ntot=209 /MaxReadThrough="2.44114" /MaxDrop="4.07715" /score="22.1532141" /energy="-17.1" /TU="NA" /idTUdmin="U636" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(813116..814369) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811639, 15849754, 16850406, 16862575; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388719.1" /db_xref="EnsemblGenomes-Gn:BSU08380" /db_xref="EnsemblGenomes-Tr:CAB12667" /db_xref="GOA:O31561" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12895" /db_xref="UniProtKB/Swiss-Prot:O31561" /translation="MEKPLFRNQKGLMTLLASQTISSLGDWLHILAVLTLAAFQLHAS PLDMSLLMMSFALPVIVLGPVSGLLADRFDRKTIMFLSEIGRALTVISCVYVSELWQL YVLLSVQSCFSSLFLPAKNGKLKELAPEAHIQQAVSVSSIIDNSSKIFGPALGGTLIA AFSIHSVFYINAGAFFLSAVILFFLPRDAFLQKANTPQEKTAALTSIKEGLQFLKRMP LLLTGLLTACVVLFVLQIGDSQAIILIRSFSGAPPELAGWCMAVSGAGMLLTAAITGR RRITSYLLYFSAGTLLLGLATGGAPFLSGMGIAGITLFIFAFFIMGAAFGLVHIPFQI LVQTTVPVDYSGRVFGAIQSATTLASILGMAGGGVLAEWIGVSLAFLVCGCLLIMIGL ITLIGKKIAESRRYLVTKSNKGAQG*" /label="yfiS CDS" gene complement(813116..814369) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /label="yfiS gene" promotor_-10 complement(813177..813196) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(813189) /Source="Nicolas_upshifts" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(813210..813217) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(814403..814422) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(814421) /Source="Nicolas_upshifts" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(814437..814444) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 814448..814467 /Source="Nicolas_upshift_promotors" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 814453 /Source="Nicolas_upshifts" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="upshifts" CDS 814493..815029 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15581359, 22059487, 24821014, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15581359, 22059487, 24821014, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol S-transferase" /protein_id="NP_388720.1" /db_xref="EnsemblGenomes-Gn:BSU08390" /db_xref="EnsemblGenomes-Tr:CAB12668" /db_xref="GOA:O31562" /db_xref="InterPro:IPR023774" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="PDB:1RXQ" /db_xref="SubtiList:BG12896" /db_xref="UniProtKB/Swiss-Prot:O31562" /translation="MTSVNLSYPIGEYKPRESISKEQKDKWIQVLEEVPAKLKQAVEV MTDSQLDTPYRDGGWTVRQVVHHLADSHMNSYIRFKLSLTEETPAIRPYDEKAWSELK DSKTADPSGSLALLQELHGRWTALLRTLTDQQFKRGFYHPDTKEIITLENALGLYVWH SHHHIAHITELSRRMGWS*" /label="bstA CDS" gene 814493..815029 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /label="bstA gene" CDS complement(815026..816582) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388721.1" /db_xref="EnsemblGenomes-Gn:BSU08400" /db_xref="EnsemblGenomes-Tr:CAB12669" /db_xref="GOA:O31563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12897" /db_xref="UniProtKB/Swiss-Prot:O31563" /translation="MSEALTEQKSQKWAISLFTIGVFMAALDNGIISAALTTINESFS VSPSWGSWGITLYTLGLSVSVPIVGKLSDRYGRKKLFLIEVCLFGLGSLLVALSQSFP LFLISRLIQALGGGGIFIIGSSHILATLPKEKQGKALGLLGAMNGMAAVLGPNIGSFL LDWTGSWHWLFLINLPIAVLLVVFGACFIAETKAPEAKRLDAAGIFLLSLSILAVMYG MTNLDGANLLHSLGNPEVYGCIIFGILCFAALISYEKRVEMRGGDPILAYSLLRNHMF QRTLIIGLLSGGLLAAVIFIPSYVEQYLGVPAAKAGYWMTPLALASGIGAWLGGALTD KKGPVKTVILSGIISCAGFALFPLWVTEKWEFVIASVAAGIGFGFLLGAPLNVLVSEA AKTNKGTALGTLSLVRQIGLTLAPTLYAGFITAGFDQIGDEINSRLSDSGYSEKAMQM IPEIDSSEVSSLQEQIERIPVPEVKTAISDAIHASVASGYDHLYAAAAVVSLLVIAAI SIPAFRRQKR*" /label="yfiU CDS" gene complement(815026..816582) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /label="yfiU gene" promotor_-10 complement(816604..816622) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(816621) /Source="Nicolas_upshifts" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(816638..816641) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(816693..817175) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18990441; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388722.1" /db_xref="EnsemblGenomes-Gn:BSU08410" /db_xref="EnsemblGenomes-Tr:CAB12670" /db_xref="GOA:O31564" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12898" /db_xref="UniProtKB/Swiss-Prot:O31564" /translation="MEYNLHDTTVLNENILSSEEREIWVLYMKVLTSAGLGDVSEWMK LDMSMPQMKVLMLLNNHGTLKVSDIAEKMGASLSNTTGLLDRLEKSGFVKRSHSEEDR RSVVVQLTENAKKIFRGLYEKGHLKLKRSLELLSPEEKQAVYEGLSILSRALENAKKE *" /label="yfiV CDS" gene complement(816693..817175) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /label="yfiV gene" downshifts complement(816709) /Source="Nicolas_upshifts" /id="D418" /incds=0 /nref=58 /ntot=177 /MaxReadThrough="1.47849" /MaxDrop="4.15907" /score="27.2704527" /energy="-14.2" /TU="NA" /idTUdmin="U640" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(817200..817219) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(817216) /Source="Nicolas_upshifts" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(817234..817240) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 817261..817268 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 817282..817301 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 817290 /Source="Nicolas_upshifts" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="upshifts" CDS 817347..819917 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /EC_number="2.3.2.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol lysyltransferase involved in tRNA-dependent lysinylation of phospholipids" /protein_id="YP_003097695.1" /db_xref="EnsemblGenomes-Gn:BSU08425" /db_xref="EnsemblGenomes-Tr:CAX52582" /db_xref="GOA:C0H3X7" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022791" /db_xref="InterPro:IPR024320" /db_xref="UniProtKB/Swiss-Prot:C0H3X7" /translation="MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVIN GLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFG GLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEK PWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTV IYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAI VTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAV LVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLI LPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQ ASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAII IVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDG NALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYH DFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEE LKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEIS VDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAA VIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV *" /label="mprF CDS" gene 817347..819917 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /label="mprF gene" downshifts 819888 /Source="Nicolas_upshifts" /id="D419" /incds=0 /nref=121 /ntot=252 /MaxReadThrough="1.79352" /MaxDrop="5.78159" /score="49.2396824" /energy="-16.1" /TU="NA" /idTUdmin="U641" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(819935..820912) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 19254027, 24606332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter binding lipoprotein" /protein_id="NP_388725.1" /db_xref="EnsemblGenomes-Gn:BSU08440" /db_xref="EnsemblGenomes-Tr:CAB12673" /db_xref="GOA:O31567" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12901" /db_xref="UniProtKB/Swiss-Prot:O31567" /translation="MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAM GTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVG LETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANA VNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQ LGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQW TSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK*" /label="sxzY CDS" gene complement(819935..820912) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /label="sxzY gene" downshifts complement(819946) /Source="Nicolas_upshifts" /id="D420" /incds=0 /nref=165 /ntot=248 /MaxReadThrough="1.28876" /MaxDrop="7.70135" /score="35.2605181" /energy="-16.1" /TU="NA" /idTUdmin="U643" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 820927..820934 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(820939..820958) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 820949..820968 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 820951..821042 /Source="Nicolas_S_feature" /locus_tag="new_920382_920473" /HighExp="dia0, Lbexp, LBGexp, H2O2, G150, GM 10, Oxctl, dia15, Paraq, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S287" upshifts 820951 /Source="Nicolas_upshifts" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(820956) /Source="Nicolas_upshifts" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(820973..820980) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-35" CDS 821043..822044 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388726.1" /db_xref="EnsemblGenomes-Gn:BSU08450" /db_xref="EnsemblGenomes-Tr:CAB12674" /db_xref="GOA:O31568" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12902" /db_xref="UniProtKB/Swiss-Prot:O31568" /translation="MICKKASSKWIVLVCLIFILLTAVCASVVYGYTGTSWRQVYQAF TSFNGTNEHVIIKDVRLPRALVATVVGASLAAAGALMQALTKNPLASPGIFGINAGAG FFIVAGSFFLHIQSPQALVWSSFLGAAFTAAIVYAAGSLGREGLTPIKLTLAGAAMAA MFSSLTQGLLSVNELELAQVLFWLTGSVQGRSLDLLMTMFPYAAAALVICFFLGQKIN LLVMGEDVAKGLGQKTGLLKFVMALCVVMLAGSAVAIAGPISFIGIIIPHFARFVVGN DYRWVLPFSAVLGAILLVCADIGARYIIMPQEVPVGVMTAIIGMPVFVYIARRGAKL* " /label="sxzZ CDS" gene 821043..822044 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /label="sxzZ gene" CDS 822041..823072 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388727.1" /db_xref="EnsemblGenomes-Gn:BSU08460" /db_xref="EnsemblGenomes-Tr:CAB12675" /db_xref="GOA:O31569" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12876" /db_xref="UniProtKB/Swiss-Prot:O31569" /translation="MKLRFGVTAAEKKAWIVFLVLLGLTAAVLIISAGLGQRFIPPWD VAKTFFGAGSKLDELMIMSFRMPRILTALCAGVCLAAAGAILQGLVRNPLASPDIIGI TGGAAVAVVLLMMFFSDRSSSLTISLSWLPAAAFIGASAVGLIVYLLAYKNGASTFRL VLIGIGFSMSAQAMTTLLMIKGPIYRASQANVYITGSVYGSNWQHVKIAIILSVILLF ICFVALKNMNIQVLGEDIAAGAGSAVQRNRFFLLLLSTALTGCAVSVAGTIGFVGLMA PHIARRLVGSSYGALLPASALIGALLVLTADIVGRTLFAPVEVPAGVFTAAIGAPYFI YLLYKTRNS*" /label="sxzA CDS" gene 822041..823072 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /label="sxzA gene" downshifts 823053 /Source="Nicolas_upshifts" /id="D421" /incds=0 /nref=24 /ntot=154 /MaxReadThrough="3.26686" /MaxDrop="4.27732" /score="19.6751667" /energy="-12.8" /TU="NA" /idTUdmin="U642" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 823123..823125 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 823141..823160 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 823144 /Source="Nicolas_upshifts" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 823187..824068 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /EC_number="5.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="NP_388728.1" /db_xref="EnsemblGenomes-Gn:BSU08470" /db_xref="EnsemblGenomes-Tr:CAB12676" /db_xref="GOA:O31570" /db_xref="InterPro:IPR003719" /db_xref="SubtiList:BG12877" /db_xref="UniProtKB/Swiss-Prot:O31570" /translation="MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAG YSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKA GILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTG IWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSP YSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVK VNMTGTAVYSETRILKI*" /label="yfhB CDS" gene 823187..824068 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /label="yfhB gene" promotor_-35 824079..824086 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 824102..824121 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 824111 /Source="Nicolas_upshifts" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 824156..824740 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 22287527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (nitroreductase family)" /protein_id="NP_388729.1" /db_xref="EnsemblGenomes-Gn:BSU08480" /db_xref="EnsemblGenomes-Tr:CAB12677" /db_xref="GOA:O31571" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR026021" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12878" /db_xref="UniProtKB/Swiss-Prot:O31571" /translation="MPQTEQIHQHSVLRDIIRSRRSIRKFKQEPVPSAVILDMLETAK YAPNHRVTEPWRFIYVSSETGKANLINTFAAFSKKSKPDMTEEKLQNFKNTLGRVPGF LLVVFQEDENERARDDDFAATSSLIQNLQLLAWEKGIGMVWKSGKILYDKEVHQAFGL QDNERFAAIIQTGYPDEAPEVKKRTPIRDRFTEM*" /label="yfhC CDS" gene 824156..824740 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /label="yfhC gene" downshifts 824727 /Source="Nicolas_upshifts" /id="D422" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="3.27483" /MaxDrop="6.40857" /score="21.7703837" /energy="-18.2" /TU="U645" /idTUdmin="U644" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(824779..824970) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388730.1" /db_xref="EnsemblGenomes-Gn:BSU08490" /db_xref="EnsemblGenomes-Tr:CAB12678" /db_xref="InterPro:IPR025435" /db_xref="SubtiList:BG12879" /db_xref="UniProtKB/Swiss-Prot:O31572" /translation="MGRNHIHKNRDKNKQKLPQVPDALKRETDGVYEEYSTELADADD REAQERAKAADNRAKKKSR*" /label="yfhD CDS" gene complement(824779..824970) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /label="yfhD gene" downshifts complement(824797) /Source="Nicolas_upshifts" /id="D423" /incds=0 /nref=65 /ntot=197 /MaxReadThrough="0.436919999999999" /MaxDrop="8.51174" /score="30.1998663" /energy="-18.2" /TU="NA" /idTUdmin="U649" /TUdmin=7 /isTUend="TRUE" /label="downshifts" upshifts complement(825002) /Source="Nicolas_upshifts" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(825005..825016) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(825031..825037) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(825037..825147) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388731.1" /db_xref="EnsemblGenomes-Gn:BSU08500" /db_xref="EnsemblGenomes-Tr:CAB12679" /db_xref="InterPro:IPR025437" /db_xref="SubtiList:BG12880" /db_xref="UniProtKB/Swiss-Prot:O31573" /translation="MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK*" /label="yfhE CDS" gene complement(825037..825147) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /label="yfhE gene" promotor_-10 complement(825176..825187) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(825178) /Source="Nicolas_upshifts" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(825202..825208) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(825202..826113) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotide-or NAD-binding protein" /protein_id="NP_388732.1" /db_xref="EnsemblGenomes-Gn:BSU08510" /db_xref="EnsemblGenomes-Tr:CAB12680" /db_xref="GOA:O31574" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR010099" /db_xref="InterPro:IPR013549" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12881" /db_xref="UniProtKB/Swiss-Prot:O31574" /translation="MNIAMTGGTGFLGQHLTGVLTRQGHHVYILSRNARETEQKNMTY VQWLSEGAAPEQELPHIDVWINLAGKSIFGRWTEKTKQHILSSRINATREVQRLIQKQ KEKPKTLIQASAVGIYGTSLEKTFTEDSATSDEDFLSHTAHLWEKEGQHIEAMGIRTV YARFGVMLGEKGALPLMILPYKFLAGGTIGTGRQWLSWIHVEDAAQMIRYAVENAGIS GPMNVTAPNPVDMKQFGKTIARVKHRPHWLPVPEFFLSKALGEMSLLIVKGQRALPKK AITSGFRFTYSDLEFALSQLIADRKTV*" /label="yfhF CDS" gene complement(825202..826113) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /label="yfhF gene" promotor_-35 825999..826002 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 826019..826038 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 826029..826201 /Source="Nicolas_S_feature" /locus_tag="new_925460_925632" /HighExp="LBGstat, Lbtran, T1.30H, T2.0H, T2.30H, M9-stat, T1.0H, T3.0H, Sw, G180" /AntisenseName="yfhF" /AntisenseCor="-5.3501479327985699E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S288" upshifts 826029 /Source="Nicolas_upshifts" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(826135..826153) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(826149) /Source="Nicolas_upshifts" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(826167..826173) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 826202..826996 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /function="16.3: Control" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8946165, 10869079, 12547390, 23284295, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8946165, 10869079, 12547390, 23284295, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulatory protein RecX" /protein_id="NP_388733.1" /db_xref="EnsemblGenomes-Gn:BSU08520" /db_xref="EnsemblGenomes-Tr:CAB12681" /db_xref="GOA:O31575" /db_xref="InterPro:IPR003783" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12882" /db_xref="UniProtKB/Swiss-Prot:O31575" /translation="MPFITKISTQKKNTERFNIFLDDKYAFSVDADVLVKFELKKGKE LDDLDIIEIQYGDEVKKGFNRALDFLSYRMRSTKEVEDHLKKKETSPPVIAEVIHRLN DYKYLNDQEFAAAYVSTHKKTNGKGPDVLFRELRAKGIDDDTIKEALSSFSFEDQTRE AVKHVEKLLKKDKKLSTKELKQRAQLQLQRKGFSFDVISAAMDQIEYENDEDTEKEAL RLHAEKAFRKYRYDGSYESAMKVKQFLFRKGFSLDLIEQLLQEEEY*" /label="recX CDS" gene 826202..826996 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /label="recX gene" CDS 826998..827312 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388734.1" /db_xref="EnsemblGenomes-Gn:BSU08530" /db_xref="EnsemblGenomes-Tr:CAB12682" /db_xref="InterPro:IPR014938" /db_xref="InterPro:IPR036289" /db_xref="PDB:1SF9" /db_xref="SubtiList:BG12883" /db_xref="UniProtKB/Swiss-Prot:O31576" /translation="MEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKIT MAKAYLLNPEDYSPGETYRVENTEDEFTISYLNGVFAWGYRTSSPQQEEALPISVLQE KE*" /label="yfhH CDS" gene 826998..827312 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /label="yfhH gene" S_feature complement(827220..827488) /Source="Nicolas_S_feature" /locus_tag="new_926651_926919_c" /HighExp="S8, S6, S5, S7, C30, S4, nit, ferm, BT, G135" /AntisenseName="yfhH" /AntisenseCor="-0.53569713251514905" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S289" downshifts 827302 /Source="Nicolas_upshifts" /id="D424" /incds=0 /nref=71 /ntot=206 /MaxReadThrough="2.93348" /MaxDrop="5.2859" /score="24.7235138" /energy="-11.6" /TU="NA" /idTUdmin="U648" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 827386..827391 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 827407..827426 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 827412 /Source="Nicolas_upshifts" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" CDS 827455..828648 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388735.1" /db_xref="EnsemblGenomes-Gn:BSU08540" /db_xref="EnsemblGenomes-Tr:CAB12683" /db_xref="GOA:O31577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12884" /db_xref="UniProtKB/Swiss-Prot:O31577" /translation="MSIKNPSVKFIIFVLMICTFSIGYTEYAVMGILTSIANDFHIQV SSAGLLVTAYAASVCLTGPLVTIISVKLPRKPVLLGLMAIFILSNLMSALAPNFAVLA ISRILSASIHGAFFAIAMVFASEMVPPEKRAAAAASMNGGLTVALMLGVPFGSYLGDV LNWRAVFSIITALGVIGFLGLMAAVPNRKPKVIPMLMNEWGVFKHKQVLFSFAITILG YSGVFIAYTFIEPILRHSAGFSTVGITGALFAYGLGGVAGNFFAGKVPLPLLTRTMIG VMIGLIGVLAVFPYIAIYPAAAIVATFLFGACAFGTPPLLQTKVISSSEGGTTIAAAV SVSAFNLANALGAWIGGMILNGTGSYSWLFAGGALMTACGLVLSTFAHLSEKKSVYEY QVNKG*" /label="yfhI CDS" gene 827455..828648 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /label="yfhI gene" S_feature 828649..828883 /Source="Nicolas_S_feature" /locus_tag="new_928080_928314" /HighExp="G180, Paraq, C30, Oxctl, H2O2, G135, G150, S8, Heat, LBGstat" /AntisenseName="sspK" /AntisenseCor="1.9886505145521101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S290" CDS complement(828681..828833) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054573.1" /db_xref="EnsemblGenomes-Gn:BSU08550" /db_xref="EnsemblGenomes-Tr:CAE01449" /db_xref="GOA:Q7WY75" /db_xref="InterPro:IPR012611" /db_xref="SubtiList:BG14175" /db_xref="UniProtKB/Swiss-Prot:Q7WY75" /translation="MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERM RASGKR*" /label="sspK CDS" gene complement(828681..828833) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /label="sspK gene" downshifts complement(828698) /Source="Nicolas_upshifts" /id="D425" /incds=0 /nref=24 /ntot=45 /MaxReadThrough="2.36419" /MaxDrop="4.9889" /score="20.2715496" /energy="-12.3" /TU="NA" /idTUdmin="U652" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 828862..828869 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 828883..828902 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 828885..828957 /Source="Nicolas_S_feature" /locus_tag="new_928316_928388" /HighExp="dia5, LPhT, Diami, dia15, Etha, T0.30H, H2O2, LBGstat, BC, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S291" upshifts 828885 /Source="Nicolas_upshifts" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(828892..828903) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(828902) /Source="Nicolas_upshifts" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(828918..828924) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 828958..829227 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388736.1" /db_xref="EnsemblGenomes-Gn:BSU08560" /db_xref="EnsemblGenomes-Tr:CAB12684" /db_xref="InterPro:IPR026952" /db_xref="SubtiList:BG12885" /db_xref="UniProtKB/Swiss-Prot:O31578" /translation="MNMYIEKLTNLLLEKNEMISYIQAKTWVELLWSDFEATYAKAGH AYQGEKMTEKIVTQWIENYGGQLHLFQSSRNDVNDYLNQSRGLLH*" /label="yfhJ CDS" gene 828958..829227 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /label="yfhJ gene" downshifts 829216 /Source="Nicolas_upshifts" /id="D426" /incds=0 /nref=62 /ntot=233 /MaxReadThrough="2.9538" /MaxDrop="5.3621" /score="19.3423239" /energy="-10.6" /TU="NA" /idTUdmin="U650" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 829305..829311 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 829326 /Source="Nicolas_upshifts" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 829327..829345 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 829372..829890 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388737.1" /db_xref="EnsemblGenomes-Gn:BSU08570" /db_xref="EnsemblGenomes-Tr:CAB12685" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12886" /db_xref="UniProtKB/Swiss-Prot:O31579" /translation="MKKKQVMLALTAAAGLGLTALHSAPAAKAAPLHDISVSMPSSDT YIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDRFVNADWAQIHFKGKKAYISTHFLM KTASQAKTTKQTAFYTPTPENGKAKQLSSGTEVTILGWGFSENGGFDFTWAFVDYGGV KGYIHTKDLQMR*" /label="yfhK CDS" gene 829372..829890 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /label="yfhK gene" S_feature 829891..829958 /Source="Nicolas_S_feature" /locus_tag="new_929322_929389" /HighExp="Etha, Sw, Salt, M9-stat, B60, B36, Gly, LoTm, BC, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S292" promotor_-35 829926..829935 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-35" promotor_-10 829947..829962 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-10" upshifts 829960 /Source="Nicolas_upshifts" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="upshifts" CDS 829975..830307 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor for peptide SdpC immunity" /protein_id="NP_388738.1" /db_xref="EnsemblGenomes-Gn:BSU08580" /db_xref="EnsemblGenomes-Tr:CAB12686" /db_xref="GOA:O31580" /db_xref="InterPro:IPR025962" /db_xref="SubtiList:BG12887" /db_xref="UniProtKB/Swiss-Prot:O31580" /translation="MTGLVGGGLMIIAGILIKLFPPKSINSVYGYRTRRSMSDQRLWN EANRYSASLMILSGLVIAGMGLLLGSNLFILQLILLIAACVITFMLTEKRLKIMTHSQ GGDRSGRS*" /label="spdL CDS" gene 829975..830307 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /label="spdL gene" CDS 830294..831154 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /EC_number="3.3.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16597997, 20941576" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16597997, 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stress induced epoxide hydrolase" /protein_id="NP_388739.1" /db_xref="EnsemblGenomes-Gn:BSU08590" /db_xref="EnsemblGenomes-Tr:CAB12687" /db_xref="GOA:O31581" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12888" /db_xref="UniProtKB/Swiss-Prot:O31581" /translation="MDGVKCQFVNTNGITLHVAAAGREDGPLIVLLHGFPEFWYGWKN QIKPLVDAGYRVIAPDQRGYNLSDKPEGIDSYRIDTLRDDIIGLITQFTDEKAIVIGH DWGGAVAWHLASTRPEYLEKLIAINIPHPHVMKTVTPLYPPQWLKSSYIAYFQLPDIP EASLRENDYDTLDKAIGLSDRPALFTSEDVSRYKEAWKQPGALTAMLNWYRALRKGSL AEKPSYETVPYRMIWGMEDRFLSRKLAKETERHCPNGHLIFVDEASHWINHEKPAIVN QLILEYLKNQ*" /label="ephM CDS" gene 830294..831154 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /label="ephM gene" downshifts 831152 /Source="Nicolas_upshifts" /id="D427" /incds=0 /nref=27 /ntot=191 /MaxReadThrough="5.0793" /MaxDrop="4.1326" /score="3.7712168" /energy="-8.4" /TU="U653,U654" /idTUdmin="U654" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 831212..831218 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 831232..831243 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 831240..831304 /Source="Nicolas_S_feature" /locus_tag="new_930671_930735" /HighExp="Etha, S5, M9-stat, T0.30H, Sw, T-0.40H, B60, S8, B36, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S293" upshifts 831240 /Source="Nicolas_upshifts" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(831262..831281) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(831271) /Source="Nicolas_upshifts" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 831287..831293 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(831295..831296) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 831306..831386 /Source="Nicolas_S_feature" /locus_tag="new_930737_930817" /HighExp="M9-stat, LBGexp, Lbexp, T0.30H, dia0, T1.30H, T1.0H, LBGtran, Paraq, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF, SigB" /TUshortPSig="1, 0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S294" upshifts 831306 /Source="Nicolas_upshifts" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 831308..831326 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 831387..832376 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /EC_number="2.4.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8921856, 9636707, 23632331; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bactoprenol glycosyl transferase, phageorigin" /protein_id="NP_388740.1" /db_xref="EnsemblGenomes-Gn:BSU08600" /db_xref="EnsemblGenomes-Tr:CAB12688" /db_xref="GOA:Q45539" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11834" /db_xref="UniProtKB/Swiss-Prot:Q45539" /translation="MKQGLISIIIPSYNEGYNVKLIHESLKKEFKNIHYDYEIFFIND GSVDDTLQQIKDLAATCSRVKYISFSRNFGKEAAILAGFEHVQGEAVIVMDADLQHPT YLLKEFIKGYEEGYDQVIAQRNRKGDSFVRSLLSSMYYKFINKAVEVDLRDGVGDFRL LSRQAVNALLKLSEGNRFSKGLFCWIGFDQKIVFYENVERKNGTSKWSFSSLFNYGMD GVVSFNHKPLRLCFYTGIFILLLSIIYIIATFVKILTNGISVPGYFTIISAVLFLGGV QLLSLGIIGEYIGRIYYETKKRPHYLIKEANIPNKDLPETNELKSMRRLTKMH*" /label="csbB CDS" gene 831387..832376 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /label="csbB gene" upshifts complement(831536) /Source="Nicolas_upshifts" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(831541..831545) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(831562..831566) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 832377..832447 /Source="Nicolas_S_feature" /locus_tag="new_931808_931878" /HighExp="LPhT, Heat, Etha, LBGexp, M9-stat, LBGtran, Lbexp, Sw, dia0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigB" /TUshortPSig="1, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S295" CDS 832448..835033 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23632331; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388741.2" /db_xref="EnsemblGenomes-Gn:BSU08610" /db_xref="EnsemblGenomes-Tr:CAB12689" /db_xref="GOA:O31582" /db_xref="InterPro:IPR018580" /db_xref="SubtiList:BG12889" /db_xref="UniProtKB/Swiss-Prot:O31582" /translation="MKRKHIMIYAASLLVSVLAHAFFVKEWAEGRYMTGPGDGLAQMI VFKKLLFDQYTHGNFFYNYSFGLGGGTFSQLGYYFSASFLFLAVSAAVWLLQAVQLIG ETDTLFWAESAVFISIFKLSLIIFTSASVFHYLLKHRAASFTGAVLYGVSIIYFRHEA YWEFFTDTMVWLPLLVLGAEKIIRERRPAWFIVACSLTLINNFYFAYINLIFIGIYVL FRWLIRLEPHEEKRWIQIRLFLVSGFISFGISAAAFVPVVYGFLNNLRPPYSQKIEWL NFDDNILFSSRIIIVPAAFLLFLFIISFYKNRVFRLFAGLSLLFILFHFSPYAASVFN GFSAPQNRFEYVLAFTIAGAAAAGLSQLSELKRKELLPAAAVVLLLYLYHIQRYKLDI WKPANESILLLLLMTIAALFAAAFAKKRAKMAVYGIIILSSLFVANSYQKYALSEGGD LDSVTKEYLTSEEYRGRESSELIRRLQKEDDDPLMRIDWMNGVRNNTPIIYGFNGFSA YSSILNKDLLAFYWNDLSIDMGRESVSRYASLGDRANLYSLLYGKYYMTEKTNEASVP YGFKKHLETEHYAVYENQYMLPFVKTADAIYSESELDRLPALAKEQAMLKGIILKDPS GKTEQTPKPSNLITKSDITAKQAQYQNGLLTVTGENGGELIITPKQPSSAPGDYYVSF YLKSKAKDKGFTLKVNDYVTTRKSNKSIYKTGVNNITVRVPKSGHISINLPKGTYELR NIALYEENYQTLKNAVMQNKTEKADKLNWNKNRLTFSYHLSKDQYIMLPIPYEKGWEL KINGKTQKIEKADYAFIGFKAQKGDNHIELTYYPPYFKISAIISLVSLLLAVFYIRRK KPGSI*" /label="yfhO CDS" gene 832448..835033 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /label="yfhO gene" downshifts 835002 /Source="Nicolas_upshifts" /id="D428" /incds=0 /nref=63 /ntot=217 /MaxReadThrough="2.13267" /MaxDrop="4.17784" /score="2.41489488" /energy="-13.3" /TU="NA" /idTUdmin="U657" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(835026..836009) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10463184, 10524235, 15849754, 16850406, 24237659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_388742.1" /db_xref="EnsemblGenomes-Gn:BSU08620" /db_xref="EnsemblGenomes-Tr:CAB12690" /db_xref="GOA:O31583" /db_xref="InterPro:IPR007404" /db_xref="SubtiList:BG12890" /db_xref="UniProtKB/Swiss-Prot:O31583" /translation="MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAP DIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLA VVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGIT FLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAF YVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYE VRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI*" /label="yfhP CDS" gene complement(835026..836009) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /label="yfhP gene" downshifts complement(835060) /Source="Nicolas_upshifts" /id="D429" /incds=0 /nref=28 /ntot=200 /MaxReadThrough="2.65266" /MaxDrop="4.43244" /score="25.5564412" /energy="-17.5" /TU="NA" /idTUdmin="U661" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 835483..835492 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 835505..835524 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 835509 /Source="Nicolas_upshifts" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(836010..836157) /Source="Nicolas_S_feature" /locus_tag="new_935441_935588_c" /HighExp="Diami, dia15, M9-stat, dia5, Etha, H2O2, S6, Salt, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S296" promotor_-35 836114..836118 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 836134..836153 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 836141 /Source="Nicolas_upshifts" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 836147..836224 /Source="Nicolas_S_feature" /locus_tag="new_935578_935655" /HighExp="H2O2, G150, G180, LBGstat, dia15, Diami, Oxctl, Paraq, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S297" promotor_-10 complement(836155..836174) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(836157) /Source="Nicolas_upshifts" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(836189..836196) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 836225..837334 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /EC_number="3.2.2.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10463184, 20971907, 21954439, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10463184, 20971907, 21954439, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase" /protein_id="NP_388743.1" /db_xref="EnsemblGenomes-Gn:BSU08630" /db_xref="EnsemblGenomes-Tr:CAB12691" /db_xref="GOA:O31584" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR005760" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR029119" /db_xref="SubtiList:BG12891" /db_xref="UniProtKB/Swiss-Prot:O31584" /translation="MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWV SEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAV KEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSI WDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCS AFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLET QKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSK LKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP*" /label="mutY CDS" gene 836225..837334 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /label="mutY gene" promotor_-35 837171..837175 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 837191..837210 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 837203 /Source="Nicolas_upshifts" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 837335..837647 /Source="Nicolas_S_feature" /locus_tag="new_936766_937078" /HighExp="H2O2, G150, dia15, G135, G180, Oxctl, Paraq, dia0, LBGexp, Lbexp" /AntisenseName="yfhS" /AntisenseCor="-0.72611377663365595" /AntisenseRegPval="-44.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S298" CDS complement(837342..837566) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10463184" /codon_start=1 /transl_table=11 /product="conserved protein related to sporulation" /protein_id="NP_388744.1" /db_xref="EnsemblGenomes-Gn:BSU08640" /db_xref="EnsemblGenomes-Tr:CAB12692" /db_xref="SubtiList:BG12892" /db_xref="UniProtKB/Swiss-Prot:O31585" /translation="MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSK YRELTQEIEARGGMKRNEADYSHGTRVSYD*" /label="yfhS CDS" gene complement(837342..837566) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /label="yfhS gene" promotor_-10 complement(837596..837607) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(837598) /Source="Nicolas_upshifts" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(837621..837627) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 837648..838400 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /EC_number="1.3.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 12440970, 17329825, 21185310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 12440970, 17329825, 21185310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase III" /protein_id="NP_388745.1" /db_xref="EnsemblGenomes-Gn:BSU08650" /db_xref="EnsemblGenomes-Tr:CAB12693" /db_xref="GOA:P71079" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIC" /db_xref="PDB:3OID" /db_xref="SubtiList:BG12221" /db_xref="UniProtKB/Swiss-Prot:P71079" /translation="MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALE TAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELE ETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIK DMVDTVEFLVSSKADMIRGQTIIVDGGRSLLV*" /label="fabL CDS" gene 837648..838400 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /label="fabL gene" promotor_-35 838417..838423 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 838438..838449 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 838439 /Source="Nicolas_upshifts" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(838446..838460) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(838467) /Source="Nicolas_upshifts" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(838469..838473) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 838469..838723 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1744043, 7592342, 9540829, 19542328, 23314362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744043, 7592342, 9540829, 19542328, 23314362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (gamma-type SASP)" /protein_id="NP_388746.1" /db_xref="EnsemblGenomes-Gn:BSU08660" /db_xref="EnsemblGenomes-Tr:CAB12694" /db_xref="GOA:P07784" /db_xref="InterPro:IPR006341" /db_xref="SubtiList:BG10789" /db_xref="UniProtKB/Swiss-Prot:P07784" /translation="MANSNNFSKTNAQQVRKQNQQSAAGQGQFGTEFASETNAQQVRK QNQQSAGQQGQFGTEFASETDAQQVRQQNQSAEQNKQQNS*" /label="sspE CDS" gene 838469..838723 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /label="sspE gene" downshifts 838721 /Source="Nicolas_upshifts" /id="D430" /incds=0 /nref=261 /ntot=269 /MaxReadThrough="1.59207" /MaxDrop="8.74804" /score="9.25353719" /energy="-9.5" /TU="NA" /idTUdmin="U660" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(838746) /Source="Nicolas_upshifts" /id="D431" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.21036" /MaxDrop="5.14076" /score="-9.78320441" /energy="-7.1" /TU="NA" /idTUdmin="U663" /TUdmin="-1687" /isTUend="FALSE" /label="downshifts" CDS 838812..839156 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388747.1" /db_xref="EnsemblGenomes-Gn:BSU08670" /db_xref="EnsemblGenomes-Tr:CAB12695" /db_xref="InterPro:IPR025572" /db_xref="SubtiList:BG12222" /db_xref="UniProtKB/Swiss-Prot:P71080" /translation="MSQRVCFMEIEMIKGGNVYTFIRLKEEPMTEFEKLVSEQMKTMD KLLDLQSELDRCKQIEAELRHLERDARLRGIQAEIAVKRKHLADIQDMFQKQTEQVIR SYRSSEKPSSFV*" /label="ygaB CDS" gene 838812..839156 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /label="ygaB gene" promotor_-35 838819..838827 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 838838..838856 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 838840 /Source="Nicolas_upshifts" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="upshifts" downshifts 839139 /Source="Nicolas_upshifts" /id="D432" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.84572" /MaxDrop="3.29993" /score="13.9694142" /energy="-11.5" /TU="U666" /idTUdmin="U660" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 839195..839202 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 839216..839235 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 839225..839299 /Source="Nicolas_S_feature" /locus_tag="new_938656_938730" /HighExp="Etha, dia15, dia5, Diami, Salt, H2O2, BC, T5.0H, Cold, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S299" upshifts 839225 /Source="Nicolas_upshifts" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="upshifts" CDS 839300..839830 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19383706, 22333191; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding factor" /protein_id="NP_388748.3" /db_xref="EnsemblGenomes-Gn:BSU08680" /db_xref="EnsemblGenomes-Tr:CAB12696" /db_xref="InterPro:IPR007295" /db_xref="InterPro:IPR016882" /db_xref="InterPro:IPR035930" /db_xref="SubtiList:BG12223" /db_xref="UniProtKB/Swiss-Prot:Q796Z1" /translation="MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDR TMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYI DYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFA PEFVDMWYERYLRYTK*" /label="ygaC CDS" gene 839300..839830 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /label="ygaC gene" downshifts 839821 /Source="Nicolas_upshifts" /id="D433" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="6.10669" /MaxDrop="3.97335" /score="-5.22328881" /energy="-7" /TU="U667" /idTUdmin="U666" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 839918..841660 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388749.2" /db_xref="EnsemblGenomes-Gn:BSU08690" /db_xref="EnsemblGenomes-Tr:CAB12697" /db_xref="GOA:P71082" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12224" /db_xref="UniProtKB/Swiss-Prot:P71082" /translation="MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVD DIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLF DHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL DVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFA IEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPL TVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKA DQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFY DVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIE AAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSA LDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDY ESQYKHLFTIQNLN*" /label="ygaD CDS" gene 839918..841660 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /label="ygaD gene" downshifts 841647 /Source="Nicolas_upshifts" /id="D434" /incds=0 /nref=87 /ntot=233 /MaxReadThrough="2.54676" /MaxDrop="5.20475" /score="22.3853226" /energy="-14.1" /TU="NA" /idTUdmin="U667" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(841737..842798) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388750.1" /db_xref="EnsemblGenomes-Gn:BSU08700" /db_xref="EnsemblGenomes-Tr:CAB12698" /db_xref="GOA:P71083" /db_xref="InterPro:IPR010343" /db_xref="SubtiList:BG12225" /db_xref="UniProtKB/Swiss-Prot:P71083" /translation="MKLGARIFKTGIAITLALYLASWIGLPAPIFAGIAAIFAIQPSI YRSFLIIIDQVQANIIGAVIATVFGLIFGPSPIMIGLTAVIVITIMLKLKIEHTISIA LVTVIAILESAGDDFLMFALIRTSTVILGVLSSFIVNLVFLPPKYETKLIHNTVENTE EIMKWIRLSMRQSTEHSILKEDIEKLKEKMIKLDQTYLLYKEERSYFKKTTYVKSRKL VLFRQAIITANRALDTLKKLHRLENEIYHMPEEFQETLTEELDYLLYWHERILMRFVG KIKPHDDAVEEGIRYKQLLTKSFLKNQQNTDEELIDYNMLNIMASAVEYREQLEHLET LITSFQTYHPKDCEIETEE*" /label="ygaE CDS" gene complement(841737..842798) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /label="ygaE gene" downshifts complement(841748) /Source="Nicolas_upshifts" /id="D435" /incds=0 /nref=181 /ntot=254 /MaxReadThrough="1.1413" /MaxDrop="7.13599" /score="26.0617552" /energy="-9.4" /TU="NA" /idTUdmin="U668" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature complement(842799..842889) /Source="Nicolas_S_feature" /locus_tag="new_942230_942320_c" /HighExp="G180, Oxctl, Paraq, C30, G150, LBGexp, LPhT, S4, G135, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S300" promotor_-10 complement(842887..842906) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(842896) /Source="Nicolas_upshifts" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(842921..842928) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(843018..844307) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231799, 19930658; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde aminotransferase, classIII aminotransferase" /protein_id="NP_388751.3" /db_xref="EnsemblGenomes-Gn:BSU08710" /db_xref="EnsemblGenomes-Tr:CAB12699" /db_xref="GOA:P71084" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11943" /db_xref="UniProtKB/Swiss-Prot:P71084" /translation="MHTKSIELHNEALQHIVGGVNSPSRSYKAVGGGSPVAMEKASGA YFWDVDGNKYIDYLAAYGPIITGHAHPHITEAIKKAAENGVLYGTPTKHEVTFAKMLK EAIPAMDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS TLGTPDSAGVPKSIANEVITVPFNDIDSYKAALEKWGSEIAAVLVEPIVGNFGIVEPK EGFLEQVNELTHNAGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIG AYGGKQEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEKGVYEKLDHLGAMLE EGILKHAETHGITITVNRLKGALTVYFSDEKVENYEQAERSDGETFSTFFKLMLERGI NLAPSKYEAWFITTAHTEQDIKDTLTAVEDAFKHLKN*" /label="gsaB CDS" gene complement(843018..844307) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /label="gsaB gene" downshifts complement(843021) /Source="Nicolas_upshifts" /id="D436" /incds=0 /nref=235 /ntot=258 /MaxReadThrough="2.54961" /MaxDrop="5.8522" /score="29.5551149" /energy="-11" /TU="NA" /idTUdmin="U669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(844335..844354) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(844354) /Source="Nicolas_upshifts" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(844356..845067) /Source="Nicolas_S_feature" /locus_tag="new_943787_944498_c" /HighExp="LoTm, M9-stat, B60, S8, C30, Cold, B36, T1.30H, Etha, T2.0H" /AntisenseName="ygaF" /AntisenseCor="-0.29702219161000198" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S301" promotor_-35 complement(844366..844371) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 844400..844407 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 844421..844440 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 844421 /Source="Nicolas_upshifts" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="upshifts" CDS 844460..844933 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /EC_number="1.11.1.15" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10644761, 11349039, 12950915, 21910476, 26723255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin with versatile activity" /protein_id="YP_054574.1" /db_xref="EnsemblGenomes-Gn:BSU08720" /db_xref="EnsemblGenomes-Tr:CAB12700" /db_xref="GOA:Q796Y8" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12226" /db_xref="UniProtKB/Swiss-Prot:Q796Y8" /translation="MTIEIGQKAPDLELKGDHGETVKLSDYKGKYIVLYFYPKDMTPG CTTEACDFRDSHESFAELDAVIIGVSPDSQEKHGKFKEKHNLPFLLLVDDEHKLAEAF DVWKLKKNFGKEYMGIERSTFLIDKEGRLIKEWRKVKVKDHVAEALQTLKDMSEK*" /label="bcp CDS" gene 844460..844933 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /label="bcp gene" promotor_-35 844970..844977 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 844992..845011 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 844998 /Source="Nicolas_upshifts" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="upshifts" CDS 845056..845493 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1580225, 16541078, 16925555, 22194458, 27935957, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Fur family)" /protein_id="NP_388753.1" /db_xref="EnsemblGenomes-Gn:BSU08730" /db_xref="EnsemblGenomes-Tr:CAB12701" /db_xref="GOA:P71086" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FE3" /db_xref="PDB:2RGV" /db_xref="PDB:3F8N" /db_xref="SubtiList:BG12227" /db_xref="UniProtKB/Swiss-Prot:P71086" /translation="MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIY KALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKI VDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH*" /label="perR CDS" gene 845056..845493 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /label="perR gene" downshifts 845475 /Source="Nicolas_upshifts" /id="D437" /incds=0 /nref=149 /ntot=247 /MaxReadThrough="3.98479" /MaxDrop="7.52234" /score="1.62878623" /energy="-12.3" /TU="U670,U671" /idTUdmin="U670" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(845528..845881) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_054575.1" /db_xref="EnsemblGenomes-Gn:BSU08740" /db_xref="EnsemblGenomes-Tr:CAE01450" /db_xref="GOA:Q7WY74" /db_xref="InterPro:IPR020912" /db_xref="SubtiList:BG14192" /db_xref="UniProtKB/Swiss-Prot:Q7WY74" /translation="MAKYSSKINKIRTFALSLVFVGFIIMYIGIFFKESVLLSSLFMI LGLLSIGLSTVVYFWIGMLSTKAVRVICPGCDKETKVLGVVDMCMHCREPLTLDKGLE GKEFDESYNKKKMSK*" /label="ygzB CDS" gene complement(845528..845881) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /label="ygzB gene" downshifts 845541 /Source="Nicolas_upshifts" /id="D438" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="2.62283" /MaxDrop="4.13562" /score="-4.23596421" /energy="-12.5" /TU="NA" /idTUdmin="U670" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(845551) /Source="Nicolas_upshifts" /id="D439" /incds=0 /nref=182 /ntot=253 /MaxReadThrough="4.02571" /MaxDrop="6.23378" /score="9.51667757" /energy="-14.2" /TU="NA" /idTUdmin="U673" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 845877..845881 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-35" promotor_-10 845889..845903 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-10" misc_feature complement(845893..845912) /Source="Nicolas_upshift_promotors" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 845893..845984 /Source="Nicolas_S_feature" /locus_tag="new_945324_945415" /HighExp="Cold, C30, H2O2, Etha, dia15, G135, Paraq, C90, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S302" upshifts 845893 /Source="Nicolas_upshifts" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="upshifts" upshifts complement(845903) /Source="Nicolas_upshifts" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 845961..845964 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-35" promotor_-10 845979..845998 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-10" S_feature 845986..846088 /Source="Nicolas_S_feature" /locus_tag="new_945417_945519" /HighExp="BMM, Cold, LBGstat, C30, Oxctl, LBGexp, Paraq, G180, Lbexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.996, 0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S303" upshifts 845986 /Source="Nicolas_upshifts" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="upshifts" CDS 846089..846973 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388755.1" /db_xref="EnsemblGenomes-Gn:BSU08750" /db_xref="EnsemblGenomes-Tr:CAB12703" /db_xref="InterPro:IPR029348" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10951" /db_xref="UniProtKB/Swiss-Prot:Q04385" /translation="MENLLRPIYQERASHPNTLAVIMIERRNKTSSLTDNFDAALLVI VKDADEPVFIKHYEFDHQTASLHVVTDSQIQEWILLGTNRRIIDWIVNGRVLFDRNEY VVELIDRLNTFPFAERKLKIGLEYGKLIRRYVEGKAFFEANQFLDAYNAVVHALHHLA RIEVIDRGFHPETTVWSQVRQMEPQVYKLYSELIESHESLEKRLELLFLANDFLIHSK AEIGSAHLFEVMKEKDIWQFGELLQHHDLKHFTQDLGVMLDYLTEKGLINVCQIETKG QAVYHRGYSFKKGVDSDS*" /label="ygxA CDS" gene 846089..846973 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /label="ygxA gene" promotor_-35 846956..846963 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 846977..846996 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 846992..847264 /Source="Nicolas_S_feature" /locus_tag="new_946423_946695" /HighExp="LBGstat, Oxctl, C30, Paraq, GM 120, H2O2, HPh, G150, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.106881" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="Sig-" /TUlongPSig="0.0739" /label="S304" upshifts 846992 /Source="Nicolas_upshifts" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(847025) /Source="Nicolas_upshifts" /id="D440" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="2.70619" /MaxDrop="3.85046" /score="4.43428373" /energy="-7.8" /TU="NA" /idTUdmin="U673" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" rRNA 847265..848819 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-16S rRNA" gene 847265..848819 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /label="rrnD-16S gene" rRNA 848987..851914 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-23S rRNA" gene 848987..851914 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /label="rrnD-23S gene" S_feature 851915..852000 /Source="Nicolas_S_feature" /locus_tag="new_951346_951431" /HighExp="G135, C30, Oxctl, Paraq, LBGstat, dia0, HiTm, Fru, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S305" promotor_-35 851976..851983 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 851997..852016 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 852002 /Source="Nicolas_upshifts" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="upshifts" rRNA 852026..852141 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-5S rRNA" gene 852026..852141 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /label="rrnD-5S gene" tRNA 852151..852225 /gene="asnTA" /locus_tag="BSU_tRNA_29" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="asparagine transfer RNA (GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="asnTA tRNA" gene 852151..852225 /gene="asnTA" /locus_tag="BSU_tRNA_29" /label="asnTA gene" tRNA 852231..852322 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Ser tRNA" gene 852231..852322 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /label="trnD-Ser gene" downshifts 852318 /Source="Nicolas_upshifts" /id="D441" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="7.64297" /MaxDrop="4.37505" /score="-9.7424199" /energy="-11" /TU="U676" /idTUdmin="U677" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" tRNA 852357..852428 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Glu tRNA" gene 852357..852428 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /label="trnD-Glu gene" tRNA 852438..852513 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Val tRNA" gene 852438..852513 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /label="trnD-Val gene" tRNA 852523..852599 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Met tRNA" gene 852523..852599 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /label="trnD-Met gene" tRNA 852611..852687 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Asp tRNA" gene 852611..852687 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /label="trnD-Asp gene" tRNA 852700..852775 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Phe(GAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Phe tRNA" gene 852700..852775 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /label="trnD-Phe gene" tRNA 852781..852853 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Thr tRNA" gene 852781..852853 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /label="trnD-Thr gene" tRNA 852876..852960 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GUA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Tyr tRNA" gene 852876..852960 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /label="trnD-Tyr gene" tRNA 852966..853039 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /product="tRNA-Trp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Trp(CCA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Trp tRNA" gene 852966..853039 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /label="trnD-Trp gene" tRNA 853064..853139 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="transfer RNA-His(GUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-His tRNA" gene 853064..853139 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /label="trnD-His gene" tRNA 853149..853220 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Gln tRNA" gene 853149..853220 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /label="trnD-Gln gene" tRNA 853270..853344 /gene="glyTB" /locus_tag="BSU_tRNA_41" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="glycine transfer RNA (GCC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="glyTB tRNA" gene 853270..853344 /gene="glyTB" /locus_tag="BSU_tRNA_41" /label="glyTB gene" tRNA 853350..853420 /gene="cysTA" /locus_tag="BSU_tRNA_42" /product="tRNA-Cys" /inference="profile:tRNAscan:1.23" /note="cysteine tRNA (GCA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="cysTA tRNA" gene 853350..853420 /gene="cysTA" /locus_tag="BSU_tRNA_42" /label="cysTA gene" tRNA 853428..853516 /gene="leuTA" /locus_tag="BSU_tRNA_43" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine RNA (UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTA tRNA" gene 853428..853516 /gene="leuTA" /locus_tag="BSU_tRNA_43" /label="leuTA gene" S_feature 853517..853593 /Source="Nicolas_S_feature" /locus_tag="new_952948_953024" /HighExp="Paraq, C30, Oxctl, G180, G135, Heat, BMM, LBGexp, dia15, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S306" downshifts 853550 /Source="Nicolas_upshifts" /id="D442" /incds=0 /nref=18 /ntot=231 /MaxReadThrough="5.36857" /MaxDrop="5.05259" /score="16.6649124" /energy="-8.9" /TU="U676" /idTUdmin="U677" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature 853595..853763 /Source="Nicolas_S_feature" /locus_tag="new_953026_953194" /HighExp="Heat, Paraq, BMM, Oxctl, H2O2, Cold, G180, Pyr, C30, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S307" promotor_-35 853720..853727 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 853726 /Source="Nicolas_upshifts" /id="D443" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.84674" /MaxDrop="3.439" /score="35.1424037" /energy="-12.4" /TU="U676" /idTUdmin="U677" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 853741..853760 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 853765 /Source="Nicolas_upshifts" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="upshifts" tRNA 853782..853863 /gene="leuTB" /locus_tag="BSU_tRNA_44" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine tRNA(CAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTB tRNA" gene 853782..853863 /gene="leuTB" /locus_tag="BSU_tRNA_44" /label="leuTB gene" promotor_-10 complement(853799..853816) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(853802) /Source="Nicolas_upshifts" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(853837..853842) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(853872) /Source="Nicolas_upshifts" /id="D444" /incds=0 /nref=5 /ntot=151 /MaxReadThrough="1.64364" /MaxDrop="6.28675" /score="7.71223568" /energy="-12.4" /TU="NA" /idTUdmin="U679" /TUdmin=18 /isTUend="TRUE" /label="downshifts" CDS complement(853942..854718) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9795118, 22142536, 26625291, 28234965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9795118, 22142536, 26625291, 28234965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="protein involved in the control of the cell cycle as a function of the environment" /protein_id="NP_388756.2" /db_xref="EnsemblGenomes-Gn:BSU08760" /db_xref="EnsemblGenomes-Tr:CAB12704" /db_xref="GOA:P71088" /db_xref="InterPro:IPR009776" /db_xref="InterPro:IPR014756" /db_xref="PDB:5CL2" /db_xref="SubtiList:BG12229" /db_xref="UniProtKB/Swiss-Prot:P71088" /translation="MSFFKKLAASAGIGAAKVDTILEKDAYFPGEEVQGTVHVKGGKI AQDIRYIDLQLSTRYVIVKDDEEHRKYATIHSFRVTGSFTIQPGEEHQFPFTFTLPLD TPITVGKVEVAVVTDLDIQGGIDKSDHDRIFVEAHPWIENVLEAIENLGFRLNEADCE QAPYFQRRLPFVQEFEFVPTSGYYRQMLDELELIFLLDEDGLEIIFEVDRRARGLRGW LEEMYNDGEQLVRVRFSQSELEDTEELEEVLEEILDQYAE*" /label="spo0M CDS" gene complement(853942..854718) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /label="spo0M gene" downshifts complement(853956) /Source="Nicolas_upshifts" /id="D445" /incds=0 /nref=9 /ntot=131 /MaxReadThrough="6.06864" /MaxDrop="6.58787" /score="6.75662782" /energy="-7" /TU="U679" /idTUdmin="U679" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(854745..854760) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(854767) /Source="Nicolas_upshifts" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(854773..854782) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 854802..854808 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 854823..854834 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 854826 /Source="Nicolas_upshifts" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="upshifts" CDS 854860..855063 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388757.2" /db_xref="EnsemblGenomes-Gn:BSU08770" /db_xref="EnsemblGenomes-Tr:CAB12705" /db_xref="SubtiList:BG12981" /db_xref="UniProtKB/Swiss-Prot:O31586" /translation="MEVNKESLVADELHRMFLAGELQITVEEDINNISERLRNGDLSL DRLSGEDVFIKETVNEALRRVEQ*" /label="ygzA CDS" gene 854860..855063 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /label="ygzA gene" downshifts 855046 /Source="Nicolas_upshifts" /id="D446" /incds=0 /nref=22 /ntot=97 /MaxReadThrough="1.47004" /MaxDrop="5.47861" /score="15.4081475" /energy="-18.2" /TU="NA" /idTUdmin="U676" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(855122) /Source="Nicolas_upshifts" /id="D447" /incds=0 /nref=10 /ntot=35 /MaxReadThrough="1.31339" /MaxDrop="4.8918" /score="26.0684119" /energy="-18.2" /TU="NA" /idTUdmin="U681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(855148..855420) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="YP_003097696.1" /db_xref="EnsemblGenomes-Gn:BSU08779" /db_xref="EnsemblGenomes-Tr:CAX52583" /db_xref="GOA:C0H3X8" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="UniProtKB/Swiss-Prot:C0H3X8" /translation="MYRSKKQSQILSYQELLKKQRRWFPIEQSLCPKDILDLLTTIKT SINKYTVATTATENPHIRRALHDQLDTAVYLHDELSDLLLEKGWLG*" /label="ygzC CDS" gene complement(855148..855420) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /label="ygzC gene" promotor_-10 complement(855379..855397) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(855386) /Source="Nicolas_upshifts" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 855401..855408 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-35" promotor_-35 complement(855414..855419) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 855421..855440 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-10" upshifts 855429 /Source="Nicolas_upshifts" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="upshifts" CDS 855462..856154 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase" /protein_id="NP_388758.2" /db_xref="EnsemblGenomes-Gn:BSU08780" /db_xref="EnsemblGenomes-Tr:CAB12706" /db_xref="GOA:P71089" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12230" /db_xref="UniProtKB/Swiss-Prot:P71089" /translation="MKQIIAMGGGGFSMEPDNLSLDQYILNQSKREQPRICFLPTASG DSQNYIQRFYHAFQTLDCVPSHLSLFKPPSSDLVSFVMEMDVIYVGGGNTRNLLVLWK EWGLDHILREAWKNGVVVAGISAGAICWFEEGVTDSAGPLTSLKSLGFLQGSFCPHYD GEKDRRPAYHQLISNKFLCSGYAADDGAALHFINDQLFQTVSSRSGAKAYRVMMAEHE IAEIPLPVKYLG*" /label="ygaJ CDS" gene 855462..856154 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /label="ygaJ gene" promotor_-35 856183..856187 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(856186..856205) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(856198) /Source="Nicolas_upshifts" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 856201..856220 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(856220..856227) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA 856224..856331 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswD RNA" gene 856224..856331 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /label="tswD gene" upshifts 856231 /Source="Nicolas_upshifts" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="upshifts" downshifts 856362 /Source="Nicolas_upshifts" /id="D448" /incds=0 /nref=13 /ntot=48 /MaxReadThrough="8.09735" /MaxDrop="5.74046" /score="17.5556194" /energy="-12.4" /TU="U684" /idTUdmin="U682" /TUdmin=152 /isTUend="FALSE" /label="downshifts" CDS 856464..858236 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /EC_number="4.1.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8432721, 9370266, 10382260, 16291685, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8432721, 9370266, 10382260, 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine synthase" /protein_id="NP_388759.2" /db_xref="EnsemblGenomes-Gn:BSU08790" /db_xref="EnsemblGenomes-Tr:CAB12707" /db_xref="GOA:P45740" /db_xref="InterPro:IPR002817" /db_xref="InterPro:IPR025747" /db_xref="SubtiList:BG11246" /db_xref="UniProtKB/Swiss-Prot:P45740" /translation="MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPT TGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKP EDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEF VRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAI RWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDT LIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHF EEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEG PGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAM LCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWR DQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSE AEAINKGLKEKAKEFVDTGSNLYQ*" /label="thiC CDS" gene 856464..858236 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /label="thiC gene" downshifts 858212 /Source="Nicolas_upshifts" /id="D449" /incds=0 /nref=166 /ntot=257 /MaxReadThrough="5.77069" /MaxDrop="5.3684" /score="25.2366359" /energy="-15.3" /TU="U684" /idTUdmin="U684" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature 858257..859182 /Source="Nicolas_S_feature" /locus_tag="new_957688_958613" /HighExp="HiOs, GM-0.1, GM 45, GM 60, GM-0.2, BMM, MG 90, T-5.40H, MG 15, MG 25" /AntisenseName="ygaK" /AntisenseCor="-9.7288827054566707E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="SigA" /TUlongPSig=1 /label="S308" CDS complement(858274..859629) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /EC_number="1.21.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8972604; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FAD-dependent oxido-reductase" /protein_id="NP_388760.2" /db_xref="EnsemblGenomes-Gn:BSU08800" /db_xref="EnsemblGenomes-Tr:CAB12708" /db_xref="GOA:Q796Y5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12231" /db_xref="UniProtKB/Swiss-Prot:Q796Y5" /translation="MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQD ALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAG AELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVA DEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDD FEEVYNTWQNWAPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGS PTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQ NASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSL SKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLF F*" /label="ygaK CDS" gene complement(858274..859629) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /label="ygaK gene" promotor_-10 complement(859657..859676) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(859674) /Source="Nicolas_upshifts" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(859690..859699) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 859747..859753 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 859768..859787 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 859796 /Source="Nicolas_upshifts" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="upshifts" CDS 859880..860077 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1479343, 2108127, 8323536, 16321961" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1479343, 2108127, 8323536, 16321961; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (repressor of ScoC)" /protein_id="NP_388761.2" /db_xref="EnsemblGenomes-Gn:BSU08810" /db_xref="EnsemblGenomes-Tr:CAB12709" /db_xref="GOA:P21344" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG10747" /db_xref="UniProtKB/Swiss-Prot:P21344" /translation="MGVKKEKGRKRFRKRKTYGNQILPLELLIEKNKREIINSAELME EIYMKIDEKHTQCVTKYKKTR*" /label="senS CDS" gene 859880..860077 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /label="senS gene" CDS complement(860104..861555) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /EC_number="1.11.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 12486061, 16535198, 22194458, 27935957" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12486061, 16535198, 22194458, 27935957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vegetative catalase 1" /protein_id="NP_388762.2" /db_xref="EnsemblGenomes-Gn:BSU08820" /db_xref="EnsemblGenomes-Tr:CAB12710" /db_xref="GOA:P26901" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG10849" /db_xref="UniProtKB/Swiss-Prot:P26901" /translation="MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFN RERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSA DTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTA VWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTE QGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPF DVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRL FAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKE SPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKE EIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS*" /label="katA CDS" gene complement(860104..861555) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /label="katA gene" downshifts complement(860114) /Source="Nicolas_upshifts" /id="D450" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="1.32399" /MaxDrop="8.8938" /score="25.1548262" /energy="-8.3" /TU="NA" /idTUdmin="U688" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 861532..861538 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 861553..861572 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 861556 /Source="Nicolas_upshifts" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(861573..861592) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 861578..861907 /Source="Nicolas_S_feature" /locus_tag="new_961009_961338" /HighExp="S8, C30, S7, S6, BT, C90, B36, S4, S5, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.528" /TUlongSig="NA" /TUlongPSig="NA" /label="S309" upshifts complement(861592) /Source="Nicolas_upshifts" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(861606..861613) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(861651..861669) /Source="Nicolas_upshift_promotors" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(861676) /Source="Nicolas_upshifts" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" downshifts 861864 /Source="Nicolas_upshifts" /id="D451" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="5.89897" /MaxDrop="4.66837" /score="39.0049465" /energy="-19.7" /TU="U687" /idTUdmin="U686" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" CDS 861963..862730 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (ATP-bindingprotein)" /protein_id="NP_388763.3" /db_xref="EnsemblGenomes-Gn:BSU08830" /db_xref="EnsemblGenomes-Tr:CAB12711" /db_xref="GOA:P97027" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017875" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12232" /db_xref="UniProtKB/Swiss-Prot:P97027" /translation="MAVTISIKEKAFVQEGRKNTVLENIELSIAPGEFLTLIGPSGCG KSTLLKIIAGLDSEYDGSVEINGRSVTAPGIQQGFIFQEHRLFPWLTVEQNIAADLNL KDPKVKQKVDELIEIVRLKGSEKAYPRELSGGMSQRVAIARALLREPEVLLLDEPFGA LDAFTRKHLQDVLLDIWRKKKTTMILVTHDIDESVYLGNELAILKAKPGKIHKLMPIH LAYPRNRTTPDFQAIRQRVLSEFEKTEDLEYAEGSGI*" /label="ssuB CDS" gene 861963..862730 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /label="ssuB gene" CDS 862748..863746 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type f: factor" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (binding lipoprotein)" /protein_id="NP_388764.1" /db_xref="EnsemblGenomes-Gn:BSU08840" /db_xref="EnsemblGenomes-Tr:CAB12712" /db_xref="GOA:P40400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR010067" /db_xref="InterPro:IPR015168" /db_xref="SubtiList:BG10656" /db_xref="UniProtKB/Swiss-Prot:P40400" /translation="MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPL LIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGI DFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLS ANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGF TLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNT EPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ*" /label="ssuA CDS" gene 862748..863746 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /label="ssuA gene" CDS 863743..864573 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11390694, 15849754, 16513748, 16850406, 16885442, 9782504" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15849754, 16513748, 16850406, 16885442, 9782504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (permease)" /protein_id="NP_388765.1" /db_xref="EnsemblGenomes-Gn:BSU08850" /db_xref="EnsemblGenomes-Tr:CAB12713" /db_xref="GOA:P40401" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10657" /db_xref="UniProtKB/Swiss-Prot:P40401" /translation="MMKAEAAGSLPKTNAEAVRKKPGRKRYGWMKGLLLPAVIIAIWQ VIGGLGVVSATVLPTPVTIVLTFKELILSGELFGHLQISIYRAALGFLLGAGLGLMIG ILAGFSKRTELYLDPSLQMLRTVPHLAVTPLFILWFGFDEVSKILLIALGAFFPVYIN TFNGIRGVDAKLFEVARVLEFKWHQQISKVILPAALPNILLGIRLSLGIAWLGLVVAE LMGSSSGVGYMIMDARQFSQTNKVFAGIIIFAVVGKLTDSFVRLLERKLLKWRNSYEG *" /label="ssuC CDS" gene 863743..864573 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /label="ssuC gene" CDS 864596..865726 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /EC_number="1.14.14.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9782504, 11390694, 16513748, 16885442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMNH2-dependent aliphatic sulfonate monooxygenase" /protein_id="NP_388766.2" /db_xref="EnsemblGenomes-Gn:BSU08860" /db_xref="EnsemblGenomes-Tr:CAB12714" /db_xref="GOA:P40402" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019911" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10658" /db_xref="UniProtKB/Swiss-Prot:P40402" /translation="MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTG VLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLL INVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNL LFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGR SVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQ GDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQALGIESFIFSGYPHLE EAYYFAELVFPLLPFENDRTRKLQNKRGEAVGNTYFVKEKNA*" /label="ssuD CDS" gene 864596..865726 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /label="ssuD gene" misc_feature 865753..865772 /Source="Nicolas_upshift_promotors" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 865759 /Source="Nicolas_upshifts" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="upshifts" CDS 865830..866366 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur-related oxidoreductase" /protein_id="NP_388767.1" /db_xref="EnsemblGenomes-Gn:BSU08870" /db_xref="EnsemblGenomes-Tr:CAB12715" /db_xref="SubtiList:BG12233" /db_xref="UniProtKB/Swiss-Prot:P97028" /translation="MLSACGHSKQMEIKAADISDLEKNRMDVAASQAFTAEAVNIGEG ISSADMYIEHYQKGKLVERFGPVRADYSEEKTDTIQFVYFENEEGEGKNKHTTIHFGI VDKQGTIAADSSVKRDDSTTQEMTQNISSPEPITFEKPALIGSSIRGTDETMHTSEHK KELIKHQDALLYYVELHH*" /label="ygaN CDS" gene 865830..866366 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /label="ygaN gene" S_feature 866367..866437 /Source="Nicolas_S_feature" /locus_tag="new_965798_965868" /HighExp="B36, BT, B60, Etha, S5, Heat, S2, BMM, S4, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25357200000000002" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S310" promotor_-35 866407..866414 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 866428..866447 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 866439 /Source="Nicolas_upshifts" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="upshifts" CDS 866478..866747 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 17163968, 19648245, 20208344, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="alternative ribosomal protein S14" /protein_id="NP_388768.1" /db_xref="EnsemblGenomes-Gn:BSU08880" /db_xref="EnsemblGenomes-Tr:CAB12716" /db_xref="GOA:O31587" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023036" /db_xref="SubtiList:BG13085" /db_xref="UniProtKB/Swiss-Prot:O31587" /translation="MAKKSKVAKELKRQQLVEQYAGIRRELKEKGDYEALSKLPRDSA PGRLHNRCMVTGRPRAYMRKFKMSRIAFRELAHKGQIPGVKKASW*" /label="rpsNB CDS" gene 866478..866747 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /label="rpsNB gene" promotor_-35 866550..866554 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 866577..866593 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 866593 /Source="Nicolas_upshifts" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 866734 /Source="Nicolas_upshifts" /id="D452" /incds=0 /nref=41 /ntot=70 /MaxReadThrough="3.14088" /MaxDrop="6.23701" /score="18.4402235" /energy="-10.1" /TU="U692" /idTUdmin="U691" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(866765..867238) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388769.1" /db_xref="EnsemblGenomes-Gn:BSU08890" /db_xref="EnsemblGenomes-Tr:CAB12717" /db_xref="GOA:P97029" /db_xref="SubtiList:BG12234" /db_xref="UniProtKB/Swiss-Prot:P97029" /translation="MSMKTKAAFHLVLFGLACWALISYFEASEGIASFFGTKSGGMVF DLNLTPFILFVAASAVYLYLQKKSRPARKQLLLPDEFEEQDEREQMMTAKACRASYIA VYFSLPAAAVLLIFYPLFQSRIPFFPIIIVFIIMIIQHLSYVISFKKNEKNSGAL*" /label="ygaO CDS" gene complement(866765..867238) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /label="ygaO gene" downshifts complement(866801) /Source="Nicolas_upshifts" /id="D453" /incds=0 /nref=105 /ntot=235 /MaxReadThrough="1.59724" /MaxDrop="4.17785" /score="7.33161195" /energy="-10.1" /TU="NA" /idTUdmin="U693" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(867240..867440) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative HTH-type transcriptional regulator" /protein_id="YP_003097697.1" /db_xref="EnsemblGenomes-Gn:BSU08899" /db_xref="EnsemblGenomes-Tr:CAX52584" /db_xref="GOA:C0H3X9" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="UniProtKB/Swiss-Prot:C0H3X9" /translation="MKNKVKELRARFGYSQEKLGETVGVTRQTVAAIEKGDYVPSLLL ALKICKAFSMKMEDVFWLEEEN*" /label="ygzD CDS" gene complement(867240..867440) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /label="ygzD gene" promotor_-10 complement(867469..867488) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(867483) /Source="Nicolas_upshifts" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(867501..867508) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 867564..867569 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 867583..867602 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 867583 /Source="Nicolas_upshifts" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="upshifts" tRNA 867634..867707 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(TCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gly1 tRNA" gene 867634..867707 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /label="trnSL-Gly1 gene" S_feature 867708..867890 /Source="Nicolas_S_feature" /locus_tag="new_967139_967321" /HighExp="G135, G180, Oxctl, G150, Paraq, H2O2, C30, HPh, LPh, LBGexp" /AntisenseName="yhzB" /AntisenseCor="0.42714037049296899" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S311" CDS complement(867798..868421) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388771.1" /db_xref="EnsemblGenomes-Gn:BSU08900" /db_xref="EnsemblGenomes-Tr:CAB12718" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG13086" /db_xref="UniProtKB/Swiss-Prot:O31588" /translation="MNIKLDSVITERAAGLHAAAVIYENIEVGSSPQMLKGRLRLFQE SLFFDYADGGISDESFVKEWQKLFKQLNPSFEGETTPMEDMLVPISKEQFMESKDSAH DTIDFFALKYSLPIMIYDAGKLHEPVRISLGEKENILLFSDENGIFGDFKNSVNHYPV SNETKNMLQIIFFPPSIEKSSAVNLLSSLTKMFEQIHGGTHTVHWLT*" /label="yhzB CDS" gene complement(867798..868421) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /label="yhzB gene" downshifts complement(867813) /Source="Nicolas_upshifts" /id="D454" /incds=0 /nref=25 /ntot=165 /MaxReadThrough="2.50849" /MaxDrop="4.62652" /score="-8.52782087" /energy="-7.9" /TU="NA" /idTUdmin="U695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 867847 /Source="Nicolas_upshifts" /id="D455" /incds=0 /nref=1 /ntot=88 /MaxReadThrough="4.14204" /MaxDrop="2.36986" /score="16.0836885" /energy="-15.5" /TU="U694" /idTUdmin="U692" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature 867892..868503 /Source="Nicolas_S_feature" /locus_tag="new_967323_967934" /HighExp="G180, G135, G150, Paraq, Oxctl, H2O2, LBGstat, Cold, LBGexp, S6" /AntisenseName="yhzB" /AntisenseCor="0.28959466335762701" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S312" promotor_-10 complement(868445..868464) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(868466) /Source="Nicolas_upshifts" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(868478..868485) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 868504..869664 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /EC_number="1.17.99.-" /function="10.3: tRNA and rRNA base modification" /experiment="publication(s) with functional evidences, PMID:8830270, 21502530, 26230193, 27638883, 28128549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830270, 21502530, 26230193, 27638883, 28128549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epoxyqueuosine reductase" /protein_id="NP_388772.2" /db_xref="EnsemblGenomes-Gn:BSU08910" /db_xref="EnsemblGenomes-Tr:CAB12719" /db_xref="GOA:P97030" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR004453" /db_xref="InterPro:IPR013542" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="PDB:5D08" /db_xref="PDB:5D0A" /db_xref="PDB:5D0B" /db_xref="PDB:5T8Y" /db_xref="SubtiList:BG12236" /db_xref="UniProtKB/Swiss-Prot:P97030" /translation="MNVYQLKEELIEYAKSIGVDKIGFTTADTFDSLKDRLILQESLG YLSGFEEPDIEKRVTPKLLLPKAKSIVAIALAYPSRMKDAPRSTRTERRGIFCRASWG KDYHDVLREKLDLLEDFLKSKHEDIRTKSMVDTGELSDRAVAERAGIGFSAKNCMITT PEYGSYVYLAEMITNIPFEPDVPIEDMCGSCTKCLDACPTGALVNPGQLNAQRCISFL TQTKGFLPDEFRTKIGNRLYGCDTCQTVCPLNKGKDFHLHPEMEPDPEIAKPLLKPLL AISNREFKEKFGHVSGSWRGKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRG TAAWAIGKIGDPAYAEELEKALEKEKDEEAKLEIEKGIELLKASGMTKQGLS*" /label="queG CDS" gene 868504..869664 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /label="queG gene" downshifts 869673 /Source="Nicolas_upshifts" /id="D456" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="5.29174" /MaxDrop="3.3561" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 869690..869702 /Source="Nicolas_upshift_promotors" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 869695 /Source="Nicolas_upshifts" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="upshifts" CDS 869731..870666 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388773.1" /db_xref="EnsemblGenomes-Gn:BSU08920" /db_xref="EnsemblGenomes-Tr:CAB12720" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG11811" /db_xref="UniProtKB/Swiss-Prot:O31589" /translation="MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKK KLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEER MAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEK FWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSM KMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQ TYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE*" /label="yhbB CDS" gene 869731..870666 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /label="yhbB gene" downshifts complement(869749) /Source="Nicolas_upshifts" /id="D457" /incds=0 /nref=2 /ntot=17 /MaxReadThrough="2.06584" /MaxDrop="3.33944" /score="-3.35852865" /energy="-6" /TU="NA" /idTUdmin="U695" /TUdmin="-1936" /isTUend="FALSE" /label="downshifts" promotor_-35 870650..870653 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 870668 /Source="Nicolas_upshifts" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 870669..870688 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 870704..871186 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /EC_number="2.1.1.207" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 20855540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (cytidine(34)-2'-O)-methyltransferase" /protein_id="NP_388774.2" /db_xref="EnsemblGenomes-Gn:BSU08930" /db_xref="EnsemblGenomes-Tr:CAB12721" /db_xref="GOA:O31590" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR016914" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG11802" /db_xref="UniProtKB/Swiss-Prot:O31590" /translation="MNIVALHVVLYQPEIPANTGNIARTCAATNTTLHLIRPLGFSTD DKMLKRAGLDYWEFVNVVYHDSLEELFEAYKKGKFFFITKFGQQPHTSFDYTDLDEDY FFVFGRETSGLPKDLIQNNMDRCLRLPMTEHVRSLNLSNTAAILVYEALRQQNYRDLK *" /label="trmL CDS" gene 870704..871186 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /label="trmL gene" downshifts 871169 /Source="Nicolas_upshifts" /id="D458" /incds=0 /nref=203 /ntot=259 /MaxReadThrough="4.6846" /MaxDrop="7.03587" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U696" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 871236..871952 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="NP_388775.1" /db_xref="EnsemblGenomes-Gn:BSU08940" /db_xref="EnsemblGenomes-Tr:CAB12722" /db_xref="InterPro:IPR025063" /db_xref="SubtiList:BG12237" /db_xref="UniProtKB/Swiss-Prot:P97032" /translation="MLCFVFGLNNVTVLCYNVPIKGAGLMEEQLISKKELLERTSISY GQLYRWKRKNLIPEEWFIRKSTFTGQETFFPREEILKRISMIQKMKENLSLDEMREML SPKMKDVSMTADELLHKGLVSRPALEAYSEDGGSPVFSSSDLLSLFVLEGLLQSGNVS LAEAKMAAEVLKKHDTEEIEKQTELIVLRKLGVTTCFIAAAADSILFESSVKVVERVD LLKASEELKTTFMQEGHQWM*" /label="yhbD CDS" gene 871236..871952 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /label="yhbD gene" promotor_-35 871256..871263 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 871278..871297 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 871279 /Source="Nicolas_upshifts" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="upshifts" CDS 871943..872656 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388776.1" /db_xref="EnsemblGenomes-Gn:BSU08950" /db_xref="EnsemblGenomes-Tr:CAB12723" /db_xref="InterPro:IPR007607" /db_xref="SubtiList:BG10802" /db_xref="UniProtKB/Swiss-Prot:P39132" /translation="MDVVEKLVINGSGSSKGGTFQSVEINGSGTVAGDVECDTFSFNG NGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGT VKADGIDISGKAVMEADCETETFQSEGKCKISGLLNADQVIIKLSAGESYAREIGCRH LQVTCRKGMLTLLRLMPQPVLTAELIEGDVIELTNTKAKTVRGNKVIIGPDCQIETVE YSGDYTCDPSASVETSTKL*" /label="yhbE CDS" gene 871943..872656 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /label="yhbE gene" CDS 872668..873375 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388777.2" /db_xref="EnsemblGenomes-Gn:BSU08960" /db_xref="EnsemblGenomes-Tr:CAB12724" /db_xref="SubtiList:BG10803" /db_xref="UniProtKB/Swiss-Prot:P39133" /translation="METTKLGNLKLYGAGHAAGGAYHNVSIKGEGIVGEGLSAVGCRI YGTGLFLGKAETERLRVLGESECKGDLTAGKINIYGTMKVSGSLQFDRFNLKGQTEIG GNMTGESCDVKGKLSVIGDCETEMFHVTGCVDVSGLLNSGEIKLGLSHDISHVQEIGG TTITVKRRASFFSRKKGKLIADVIEGDRVYLENTEAAVVRGKEVIIGPGCSIGTIEYE YKCECDPHSQIKEKTKL*" /label="yhbF CDS" gene 872668..873375 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /label="yhbF gene" downshifts 873259 /Source="Nicolas_upshifts" /id="D459" /incds=1 /nref=1 /ntot=127 /MaxReadThrough="4.34704" /MaxDrop="2.64409" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 873303 /Source="Nicolas_upshifts" /id="D460" /incds=1 /nref=2 /ntot=35 /MaxReadThrough="4.02504" /MaxDrop="3.21894" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 873369 /Source="Nicolas_upshifts" /id="D461" /incds=0 /nref=2 /ntot=41 /MaxReadThrough="1.06365" /MaxDrop="3.74046" /score="45.497414" /energy="-15.3" /TU="NA" /idTUdmin="U698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(873402..873577) /Source="Nicolas_S_feature" /locus_tag="new_972833_973008_c" /HighExp="M9-stat, BC, S4, T0.30H, LoTm, Lbstat, S2, BT, HiOs, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99846699999999999" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S313" downshifts complement(873445) /Source="Nicolas_upshifts" /id="D462" /incds=0 /nref=63 /ntot=220 /MaxReadThrough="3.38525" /MaxDrop="4.33005" /score="18.2489321" /energy="-13.5" /TU="U699" /idTUdmin="U699" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(873569..873588) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(873577) /Source="Nicolas_upshifts" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(873603..873610) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 873642..873647 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 873663..873681 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 873663 /Source="Nicolas_upshifts" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 873725..875620 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8626065, 12662922, 25983726, 27806131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8626065, 12662922, 25983726, 27806131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine protein kinase (involved in sporulation)" /protein_id="NP_388778.1" /db_xref="EnsemblGenomes-Gn:BSU08970" /db_xref="EnsemblGenomes-Tr:CAB12725" /db_xref="GOA:P39134" /db_xref="InterPro:IPR010650" /db_xref="InterPro:IPR013153" /db_xref="InterPro:IPR016230" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10804" /db_xref="UniProtKB/Swiss-Prot:P39134" /translation="MDILKKIEKYREEEQRLKWEGTFADYLEIIKENPMVAQSAHSRV FNMIKDSGIEEIDGRKKYSFFDRELFGLEESLERLVEEYFHPAAKRLDVRKRILLLMG PVSGGKSTLVTMLKKGLEAYTLTDNGAVYAIKGCPMHEDPLHLIPHHLRDDFYREYGI RIEGSLSPLNVMRLEEEYGGRIEDVKVERIFFSEDKRTGIGTFSPSDPKSQDIADLTG SIDFSTIAEYGSESDPRAYRFDGELNKANRGMMEFQEMLKCDEKFLWHLLSLTQEGNF KAGRFALISADELIVAHTNETEYRSFISNKKNEALHSRIIVMPVPYNLKVSEEERIYE KMIAESDVADVHIAPHTLKVAAMFSILTRLKEPKRSDIDLVKKMRLYDGESVEGYNSV DVEDMKKEYNDEGMSGIDPRYVINRISSTIIRKNMESINSLDVLRSLKEGLDQHPSIS SEDRERYLNFISAARKEYDDIAKKEVQKAFVYSYEESAKTLMDNYLDNVEAYCNKNKL RDPLTGEEMNPDEKLMRSIEEQIGISENAKKAFREEILIRISAYARKGKRFDYNSHER LREAIQKKLFADLKDVVKITTSTKTPDEQQLKKVNEVVARLIDEHGYNSTSANELLKY VGSLLNR*" /label="prkA CDS" gene 873725..875620 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /label="prkA gene" promotor_no_box 874167..874267 /Source="Nicolas_upshift_promotors" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 874227 /Source="Nicolas_upshifts" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 874293 /Source="Nicolas_upshifts" /id="D463" /incds=1 /nref=5 /ntot=18 /MaxReadThrough="7.33384" /MaxDrop="5.65132" /score="45.497414" /energy="-15.3" /TU="U700" /idTUdmin="U701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 875613 /Source="Nicolas_upshifts" /id="D464" /incds=0 /nref=11 /ntot=57 /MaxReadThrough="6.19375" /MaxDrop="4.381" /score="-0.497429548" /energy="-10.6" /TU="U700" /idTUdmin="U703" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 875677..875682 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 875698..875716 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 875701..875799 /Source="Nicolas_S_feature" /locus_tag="new_975132_975230" /HighExp="S6, S7, S5, S8, S4, S3, BT, LoTm, B36, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.971, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S314" upshifts 875701 /Source="Nicolas_upshifts" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 875800..876978 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11988534, 12662922, 14523133, 25983726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 12662922, 14523133, 25983726; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination" /protein_id="NP_388779.1" /db_xref="EnsemblGenomes-Gn:BSU08980" /db_xref="EnsemblGenomes-Tr:CAB12726" /db_xref="InterPro:IPR006698" /db_xref="InterPro:IPR014230" /db_xref="SubtiList:BG11238" /db_xref="UniProtKB/Swiss-Prot:P45742" /translation="MSQNDSGHFLISEENWSLHRKGFDDQQRHQKKVQEAIKNNLPDL VTEESIIMSNGKDVVKIPIRSLDEYKIRYNYDKNKHVGQGDGESQVGDVVARDGSDKK QGPGKGQGAGDQAGEDYYEAEVSLMDLEEALFKELELPNLQQKERDNIIHTDIEFNDI RKTGLTGNIDKKRTMMSAFKRNAMSGKPSFYPIYPEDLKYKTWNDITKPESKAVVLAM MDTSGSMGVWEKYMARSFFFWMTRFLRTKYETVEIEFIAHHTEARVVSEEDFFSKGES GGTICSSVYRKSLELIDEKYNPARYNIYPFHFSDGDNLTSDNARCVKLVNDIMKKANL FCYGEVNQYNRHSTLMSAYKNVKDEKFKYYILKQKSDVFQALKNFFRNEESGVSHQFS *" /label="yhbH CDS" gene 875800..876978 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /label="yhbH gene" promotor_-35 875998..876001 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 876016..876035 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 876020 /Source="Nicolas_upshifts" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(876261) /Source="Nicolas_upshifts" /id="D465" /incds=1 /nref=1 /ntot=23 /MaxReadThrough="2.79078" /MaxDrop="2.94521" /score="-7.1109433" /energy="-11.2" /TU="NA" /idTUdmin="U699" /TUdmin="-3014" /isTUend="FALSE" /label="downshifts" downshifts 876957 /Source="Nicolas_upshifts" /id="D466" /incds=0 /nref=63 /ntot=180 /MaxReadThrough="1.86673" /MaxDrop="8.19565" /score="27.3980811" /energy="-5.6" /TU="NA" /idTUdmin="U702" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 877065..877072 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 877087..877106 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 877087 /Source="Nicolas_upshifts" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 877138..877602 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)induced by acid stress" /protein_id="NP_388780.1" /db_xref="EnsemblGenomes-Gn:BSU08990" /db_xref="EnsemblGenomes-Tr:CAB12727" /db_xref="GOA:O31592" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13003" /db_xref="UniProtKB/Swiss-Prot:O31592" /translation="MTESERALLTFEQLFDTSRAIYKKQKKILEIVLEPFDITVLQYL LMFKIHQSGSTPLSKLAMSLDLKPASVTRMTDILYKRQLMNRYDSPDDRRIVMIQLTE EGEELIEKAAVQYAKMGAGLYQKLDTSQLQYLRKLAGSLTKLAEGCSEKSGN*" /label="yhbI CDS" gene 877138..877602 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /label="yhbI gene" promotor_-35 877427..877433 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 877448..877466 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 877461 /Source="Nicolas_upshifts" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 877611..877617 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 877631..877642 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 877637 /Source="Nicolas_upshifts" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 877638..878303 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane fusion protein; putative exporter subunit (benzoate transcriptome)" /protein_id="NP_388781.1" /db_xref="EnsemblGenomes-Gn:BSU09000" /db_xref="EnsemblGenomes-Tr:CAB12728" /db_xref="GOA:O31593" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG13004" /db_xref="UniProtKB/Swiss-Prot:O31593" /translation="MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTN YVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDG TIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDT TFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVK ISE*" /label="yhbJ CDS" gene 877638..878303 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /label="yhbJ gene" CDS 878344..879942 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter (benzoate transcriptome)" /protein_id="NP_388782.1" /db_xref="EnsemblGenomes-Gn:BSU09010" /db_xref="EnsemblGenomes-Tr:CAB12729" /db_xref="GOA:P54585" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11579" /db_xref="UniProtKB/Swiss-Prot:P54585" /translation="MATGKEKNAKNPMSLLIVLMAGLFLAILNQTLLNVAMPHLMTEF GVSATTIQWLTTGYMLVNGVLIPLSAFLITRFGQRSLFLVAMFCFTLGTLVCGIAPNF STMLIGRLIQAVGGGILQPLVMTTILLIFPPESRGKGMGIFGLAMMFAPAVGPTLSGW IIEHYTWRIMFYGLVPIGAIVIIVAFFIFKNMVEPQKIKLDTLGAILSIVGFASLLYG VSEAGSDGWTDPIVLSTVIIGAIAIVAFVVQQLRHDDPMLDFRVFKYDIFSLSSVINI IITVALYTGMFLLPIYLQNLVGFTALQSGLLLLPGAIVMLIMSPISGILFDKFGPRPL AIIGLLVTVVTTYQYTQLTIDTPYTHIMLIYSIRAFGMSLLMMPVMTAGMNQLPARLN SHGTAMSNTLRQISGSIGTSLITTIYTNRTTFHYSQIADKTSTADPNFLHAFQNAVSN LMVNMNVSYDTAKTYVYSHIYKHASLDSNVMGINDAFMWATLFCVAGLILSIFLRDVR KDKLRKKKKEELSLLPAPKEAKES*" /label="yhcA CDS" gene 878344..879942 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /label="yhcA gene" CDS 879965..880495 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /EC_number="1.6.5.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15754243, 18041955, 17951395, 19665595, 20011599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:quinone oxidoreductase associated to benzoate stress" /protein_id="NP_388783.1" /db_xref="EnsemblGenomes-Gn:BSU09020" /db_xref="EnsemblGenomes-Tr:CAB12730" /db_xref="GOA:P54586" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11580" /db_xref="UniProtKB/Swiss-Prot:P54586" /translation="MKIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIR KLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYLWAEGELINKVGAVFCTTATTHGGLE MTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSEEGIQLGRA LGRRVSQVTGNLTAGQ*" /label="yhcB CDS" gene 879965..880495 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /label="yhcB gene" CDS 880508..880882 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical membrane protein" /protein_id="NP_388784.1" /db_xref="EnsemblGenomes-Gn:BSU09030" /db_xref="EnsemblGenomes-Tr:CAB12731" /db_xref="GOA:P54587" /db_xref="SubtiList:BG11581" /db_xref="UniProtKB/Swiss-Prot:P54587" /translation="MAIIIAIIAAVIVIAALITFNVRNASPGPEKQEATDRIAPPEEE KNEAHYPAEARAAEHTPSVVKNDSPKEKRDTMGDDIYRQALQKFKHSDEVHAEEEVTE ESDKMQDRSYRDALLSMKNKKK*" /label="yhcC CDS" gene 880508..880882 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /label="yhcC gene" downshifts 880871 /Source="Nicolas_upshifts" /id="D467" /incds=0 /nref=32 /ntot=145 /MaxReadThrough="1.78742" /MaxDrop="5.9171" /score="13.777309" /energy="-14.4" /TU="NA" /idTUdmin="U704" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 880882..881037 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388785.1" /db_xref="EnsemblGenomes-Gn:BSU09040" /db_xref="EnsemblGenomes-Tr:CAB12732" /db_xref="SubtiList:BG11582" /db_xref="UniProtKB/Swiss-Prot:P54588" /translation="MKKANPFTHAGLPFLLFPSIMFLSNKSMEYVVFHLDLVYYVTHT PRIFSGR*" /label="yhcD CDS" gene 880882..881037 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /label="yhcD gene" promotor_-35 880972..880978 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 880993..881012 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 881003 /Source="Nicolas_upshifts" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="upshifts" CDS 881042..881803 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane orphan protein" /protein_id="NP_388786.1" /db_xref="EnsemblGenomes-Gn:BSU09050" /db_xref="EnsemblGenomes-Tr:CAB12733" /db_xref="GOA:P54589" /db_xref="SubtiList:BG11583" /db_xref="UniProtKB/Swiss-Prot:P54589" /translation="MNSFLGLLKKDIKLSRMWLLVWICGIIFLLGTGHIIASRTKEPL VIFGFFVAVAFFLLFLSPVFVFYHLRKEGKSQLWLYNPNGGLWLFSSKLAASLLYQFV IQLALTAYGIWMYHMLSVKNLLEHQVDITSTVALLNMYGLISSLDMSVTVIVFWTVFH SLRNWRGMRWAAMVLLVAMWLFFDEYIISPLVESQKHFWPVTVYCNFDFHFHNVWRLE LKPIHLSVLGFPIAIVITFLLLIMASKLLDRKVEV*" /label="yhcE CDS" gene 881042..881803 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /label="yhcE gene" promotor_-10 complement(881355..881373) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(881369) /Source="Nicolas_upshifts" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(881389..881394) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 881806..882171 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388787.1" /db_xref="EnsemblGenomes-Gn:BSU09060" /db_xref="EnsemblGenomes-Tr:CAB12734" /db_xref="GOA:P54590" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11584" /db_xref="UniProtKB/Swiss-Prot:P54590" /translation="MDNQFQSSKPIYLQIADQIFYRLVRKELLPGDKLPSVREMAIQT KVNPNTIQRTYSEMERLGIVETRRGQGTFIAEKAEIVDELKDKLTREVLEGFVKQMKE LGLTKEEMLEGIKTFTEGG*" /label="yhcF CDS" gene 881806..882171 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /label="yhcF gene" CDS 882173..882871 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter ATP-binding protein" /protein_id="NP_388788.1" /db_xref="EnsemblGenomes-Gn:BSU09070" /db_xref="EnsemblGenomes-Tr:CAB12735" /db_xref="GOA:P54591" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11585" /db_xref="UniProtKB/Swiss-Prot:P54591" /translation="MEIKLEHVSKKYGRHTAVNDVSITLSSGRIYGLIGPNGSGKSTT LKMMAGLLFPTSGFVKVDEEQVTREMVRQTAYLTELDMFYPHFTVKDMVNFYQSQFPD FHTEQVYKLLNEMQLNPEKKIKKLSKGNRGRLKIVLALARRADVILLDEPFSGLDPMV RDSIVNSLVSYIDFEQQIVVIATHEIDEIETLLDEVIILANGEKVAQREVEDIREQEG MSVLQWFKSKMEVC*" /label="yhcG CDS" gene 882173..882871 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /label="yhcG gene" CDS 882888..883805 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7476193, 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388789.1" /db_xref="EnsemblGenomes-Gn:BSU09080" /db_xref="EnsemblGenomes-Tr:CAB12736" /db_xref="GOA:P54592" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11586" /db_xref="UniProtKB/Swiss-Prot:P54592" /translation="MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKT TTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFA RMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPT NGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVK DENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIR IYEVKVITKSLEDRFLEMTGETKEEVQHA*" /label="yhcH CDS" gene 882888..883805 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /label="yhcH gene" CDS 883798..884739 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15870467, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_388790.1" /db_xref="EnsemblGenomes-Gn:BSU09090" /db_xref="EnsemblGenomes-Tr:CAB12737" /db_xref="GOA:P54593" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11587" /db_xref="UniProtKB/Swiss-Prot:P54593" /translation="MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGES NSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTD SANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLL LILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVA TMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGT PLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN*" /label="yhcI CDS" gene 883798..884739 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /label="yhcI gene" downshifts 884721 /Source="Nicolas_upshifts" /id="D468" /incds=0 /nref=43 /ntot=186 /MaxReadThrough="2.67567" /MaxDrop="4.46232" /score="20.0218504" /energy="-13.6" /TU="NA" /idTUdmin="U707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(884831..885034) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12493834, 16352840, 22128343, 25851716" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12493834, 16352840, 22128343, 25851716; Product type f: factor" /codon_start=1 /transl_table=11 /product="major cold-shock protein, RNA helicase co-factor, RNA co-chaperone" /protein_id="NP_388791.1" /db_xref="EnsemblGenomes-Gn:BSU09100" /db_xref="EnsemblGenomes-Tr:CAB12738" /db_xref="GOA:P32081" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="PDB:1CSP" /db_xref="PDB:1CSQ" /db_xref="PDB:1NMF" /db_xref="PDB:1NMG" /db_xref="PDB:2ES2" /db_xref="PDB:2F52" /db_xref="PDB:2I5L" /db_xref="PDB:2I5M" /db_xref="PDB:3PF4" /db_xref="PDB:3PF5" /db_xref="SubtiList:BG10824" /db_xref="UniProtKB/Swiss-Prot:P32081" /translation="MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEG QAVSFEIVEGNRGPQAANVTKEA*" /label="cspB CDS" gene complement(884831..885034) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /label="cspB gene" downshifts complement(884845) /Source="Nicolas_upshifts" /id="D469" /incds=0 /nref=169 /ntot=281 /MaxReadThrough="5.28215" /MaxDrop="9.14889" /score="33.2405587" /energy="-13.1" /TU="U710" /idTUdmin="U710" /TUdmin="-48" /isTUend="FALSE" /label="downshifts" S_feature complement(885035..885162) /Source="Nicolas_S_feature" /locus_tag="new_984466_984593_c" /HighExp="BC, C90, GM 15, BI, T-1.10H, UNK1, S1, Sw, nit, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S315" misc_feature 885122..885133 /Source="Nicolas_upshift_promotors" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 885139 /Source="Nicolas_upshifts" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(885151..885170) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(885162) /Source="Nicolas_upshifts" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(885164..886302) /Source="Nicolas_S_feature" /locus_tag="new_984595_985733_c" /HighExp="C30, G180, G150, Oxctl, G135, Paraq, HPh, LPh, dia0, Lbexp" /AntisenseName="yhcJ" /AntisenseCor="0.25433958616302499" /AntisenseRegPval="-4.5999999999999996" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S316" promotor_-35 complement(885184..885189) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 885329..885336 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 885351..885369 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 885358 /Source="Nicolas_upshifts" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 885359..885469 /Source="Nicolas_S_feature" /locus_tag="new_984790_984900" /HighExp="Diami, dia15, dia5, H2O2, Salt, C90, Paraq, UNK1, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S317" CDS 885470..886300 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_388792.2" /db_xref="EnsemblGenomes-Gn:BSU09110" /db_xref="EnsemblGenomes-Tr:CAB12739" /db_xref="GOA:P54594" /db_xref="InterPro:IPR004872" /db_xref="SubtiList:BG11588" /db_xref="UniProtKB/Swiss-Prot:P54594" /translation="MKKWLICSFVLVLLVSFTACSPSAEHESIKIGIAESDGAIWNYI AQKAEEAGLDIQLIPFSDYAESDIALANKEIDANAFQTISYFQSFTEKYKLNLAPLGT TYITPMGIYSKRYERIRDISRGAVVSVPDKAFDFGRALTVLQEAGLLTLKNGFNGTGS VDMIKDNPRHLKLKAVRQQDAVSGADVFVMKPSEAKKAGLNPKKHTLKSGGLMSEEEM NLIVVRAEDQDREALQTILELYQADDTAAFIEKEYQGDLVPAFLPLKRLSDWKNEFEH *" /label="yhcJ CDS" gene 885470..886300 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /label="yhcJ gene" downshifts 886259 /Source="Nicolas_upshifts" /id="D470" /incds=0 /nref=38 /ntot=203 /MaxReadThrough="2.83059" /MaxDrop="3.90173" /score="-4.94928928" /energy="-7.3" /TU="NA" /idTUdmin="U711" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(886303..887382) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_388793.1" /db_xref="EnsemblGenomes-Gn:BSU09120" /db_xref="EnsemblGenomes-Tr:CAB12740" /db_xref="GOA:P54595" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG11589" /db_xref="UniProtKB/Swiss-Prot:P54595" /translation="MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLAC GLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSA LYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYF WIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAA DTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEF AVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLP ILADQMLYKAKETGRNRVCFSEKKE*" /label="dgcK CDS" gene complement(886303..887382) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /label="dgcK gene" promotor_-10 complement(887392..887411) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-10" upshifts complement(887413) /Source="Nicolas_upshifts" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="upshifts" promotor_-35 complement(887427..887431) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-35" promotor_-35 887489..887496 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 887510..887529 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 887516 /Source="Nicolas_upshifts" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="upshifts" CDS 887555..888946 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12193636, 15262924, 15849754, 16513748, 16850406, 19508281" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 15262924, 15849754, 16513748, 16850406, 19508281; Product type t : transporter" /codon_start=1 /transl_table=11 /product="(sodium)-cystine symporter" /protein_id="NP_388794.1" /db_xref="EnsemblGenomes-Gn:BSU09130" /db_xref="EnsemblGenomes-Tr:CAB12741" /db_xref="GOA:P54596" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11590" /db_xref="UniProtKB/Swiss-Prot:P54596" /translation="METLLVVLHVFILFLLILGLFVMQKKHVSFSKRVFTALGLGIVF GFALQLIYGPTSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLKLTKNL GKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTA KTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLGVKHKQPEQAETFKKL VDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILKLGMFVIASYAALITMFI IHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQRSMGVPEGIANFAG SFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVVAISSFGVAGVGGGA TFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGA FHDQSRVIEAEEA*" /label="tcyP CDS" gene 887555..888946 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /label="tcyP gene" S_feature complement(888582..888985) /Source="Nicolas_S_feature" /locus_tag="new_988013_988416_c" /HighExp="S8, S6, Etha, S5, S7, S4, ferm, nit, Salt, S3" /AntisenseName="tcyP" /AntisenseCor="-0.40132140065468203" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S318" downshifts 888925 /Source="Nicolas_upshifts" /id="D471" /incds=0 /nref=58 /ntot=164 /MaxReadThrough="2.37899" /MaxDrop="5.34563" /score="19.9118074" /energy="-12.8" /TU="NA" /idTUdmin="U713" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(888986..889441) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21625606" /codon_start=1 /transl_table=11 /product="expressed protein of unknown function" /protein_id="NP_388795.1" /db_xref="EnsemblGenomes-Gn:BSU09140" /db_xref="EnsemblGenomes-Tr:CAB12742" /db_xref="SubtiList:BG11591" /db_xref="UniProtKB/Swiss-Prot:P54597" /translation="MLFNQRRGISPAALIIGSTMLITALSPQIRQRISGFITGQMNRR NSENNTFDASNVGNMVKQAFSGSSGSSGDNQDRSQHQSQRQNGRQHQHAGQQQPQHQH TQSQTRQTETAAKKRQPHYAEPIHFEQNAMNVMDDNTMMEMLEDLEPGR*" /label="yhcM CDS" gene complement(888986..889441) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /label="yhcM gene" promotor_-10 complement(889456..889474) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(889484) /Source="Nicolas_upshifts" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(889489..889495) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 889533..889539 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 889553..889564 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 889557 /Source="Nicolas_upshifts" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="upshifts" CDS 889591..890160 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9611260, 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_388796.2" /db_xref="EnsemblGenomes-Gn:BSU09150" /db_xref="EnsemblGenomes-Tr:CAB12743" /db_xref="GOA:P54598" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG11592" /db_xref="UniProtKB/Swiss-Prot:P54598" /translation="MFGKKQVLASVLLIPLLMTGCGVADQGEGRRDNNDVRNVNYRNP ANDDMRNVNNRDNVDNNVNDNVNNNRVNDDNNNDRKLEVADEAADKVTDLKEVKHADI IVAGNQAYVAVVLTNGNKGAVENNLKKKIAKKVRSTDKNIDNVYVSANPDFVERMQGY GKRIQNGDPIAGLFDEFTQTVQRVFPNAE*" /label="yhcN CDS" gene 889591..890160 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /label="yhcN gene" promotor_-35 889787..889793 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 889804 /Source="Nicolas_upshifts" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 889807..889818 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 890135 /Source="Nicolas_upshifts" /id="D472" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="1.84697" /MaxDrop="7.80159" /score="33.0647397" /energy="-12.9" /TU="NA" /idTUdmin="U715" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-35 890203..890212 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 890226..890245 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 890236 /Source="Nicolas_upshifts" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="upshifts" CDS 890281..891249 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein (sporulation germination island)" /protein_id="NP_388797.2" /db_xref="EnsemblGenomes-Gn:BSU09165" /db_xref="EnsemblGenomes-Tr:CAB12744" /db_xref="SubtiList:BG11593" /db_xref="UniProtKB/Swiss-Prot:P54599" /translation="MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASG ITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDI IFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEY SHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQ EARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQF EKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE*" /label="yhcO CDS" gene 890281..891249 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /label="yhcO gene" downshifts 891125 /Source="Nicolas_upshifts" /id="D473" /incds=1 /nref=28 /ntot=62 /MaxReadThrough="1.51621" /MaxDrop="5.75619" /score="6.21571271" /energy="-16.1" /TU="NA" /idTUdmin="U717" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(891181..891834) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_388799.1" /db_xref="EnsemblGenomes-Gn:BSU09180" /db_xref="EnsemblGenomes-Tr:CAB12746" /db_xref="GOA:P54601" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG11595" /db_xref="UniProtKB/Swiss-Prot:P54601" /translation="MDQFNQQQQSQMNKGIPGKPHKNHGGHEMFDMHEVLSGTLTVLD QFMMLRQFCKDQELLNILDRQHQFITSQYNITAECFKTGSEPSQKTATYMMKEDNQTV YGMQPSQPKKPVQSMNDIDDSIISRQMLCAIKAQASMLTMASLEMTNPAVRRVLSAQI QEYVEMAFEIFLYQNKHGYYQVPQLDAQDMEQLRNSFAPAQGQMPPTQGGMGQQGLH* " /label="yhcQ CDS" gene complement(891181..891834) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /label="yhcQ gene" downshifts complement(891198) /Source="Nicolas_upshifts" /id="D474" /incds=0 /nref=15 /ntot=57 /MaxReadThrough="4.13099" /MaxDrop="4.95733" /score="8.67086892" /energy="-12.9" /TU="U718" /idTUdmin="U718" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(891865..891876) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(891867) /Source="Nicolas_upshifts" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(891891..891897) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 891906..891914 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 891917..895570 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15292138, 21800427, 22020651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292138, 21800427, 22020651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non specific extracellular Ca2+-dependent endonuclease cleaving RNA and DNA" /protein_id="NP_388800.1" /db_xref="EnsemblGenomes-Gn:BSU09190" /db_xref="EnsemblGenomes-Tr:CAB12747" /db_xref="GOA:P54602" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR019948" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR035437" /db_xref="InterPro:IPR035451" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG11596" /db_xref="UniProtKB/Swiss-Prot:P54602" /translation="MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTF EAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADR KNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNV TDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIY SPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINEL INGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINEL DEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIH LKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKV GSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAK KDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFF ASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMD YAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHE FDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVP VAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQN GNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEID KTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYS NDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKL EIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTL TVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEA SDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISR FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGT YLYVRRKRSASRT*" /label="mncR CDS" gene 891917..895570 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /label="mncR gene" promotor_-10 891925..891943 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 891940 /Source="Nicolas_upshifts" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="upshifts" CDS 895567..896163 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /EC_number="3.4.22.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12823805, 21800427, 22020651, 25038633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12823805, 21800427, 22020651, 25038633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sortase A" /protein_id="NP_388801.1" /db_xref="EnsemblGenomes-Gn:BSU09200" /db_xref="EnsemblGenomes-Tr:CAB12748" /db_xref="GOA:P54603" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG11597" /db_xref="UniProtKB/Swiss-Prot:P54603" /translation="MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKK PQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHY KDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDT SIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT*" /label="srtA CDS" gene 895567..896163 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /label="srtA gene" downshifts 896142 /Source="Nicolas_upshifts" /id="D475" /incds=0 /nref=142 /ntot=248 /MaxReadThrough="0.9984" /MaxDrop="5.92245" /score="-4.06268332" /energy="-8.8" /TU="NA" /idTUdmin="U719" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(896193..897101) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /EC_number="5.4.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9814761, 15044829; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA pseudouridine synthase" /protein_id="NP_388802.2" /db_xref="EnsemblGenomes-Gn:BSU09210" /db_xref="EnsemblGenomes-Tr:CAB12749" /db_xref="GOA:P54604" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11598" /db_xref="UniProtKB/Swiss-Prot:P54604" /translation="MNQKGRGLEILINEKQDGQWLFSVLKTALKASKPVIQDWMSHQQ IKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELDILFEDNHMLIINKPAGIA THPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQQ LEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRVSPGGQTAVTHFKVMASN AKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYGGGSKLLNRQALHANKVQAVH PITDELIVAEAPFPADMKNLCRTYFS*" /label="yhcT CDS" gene complement(896193..897101) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /label="yhcT gene" promotor_-35 897157..897165 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(897158..897169) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(897164) /Source="Nicolas_upshifts" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(897166..897652) /Source="Nicolas_S_feature" /locus_tag="new_996597_997083_c" /HighExp="S8, dia15, Diami, H2O2, G180, G150, dia5, Paraq, Oxctl, S7" /AntisenseName="yhcU" /AntisenseCor="0.69394173601478304" /AntisenseRegPval="-39.200000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S319" upshifts 897176 /Source="Nicolas_upshifts" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 897179..897198 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(897183..897189) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 897212..897607 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388803.2" /db_xref="EnsemblGenomes-Gn:BSU09220" /db_xref="EnsemblGenomes-Tr:CAB12750" /db_xref="InterPro:IPR020355" /db_xref="SubtiList:BG11599" /db_xref="UniProtKB/Swiss-Prot:P54605" /translation="MARKVIDVRIVNAATAEQESFIKELSMELIHDVFPLYFSELDIQ RFKKKGVLSLNNHYYQGTLKEAFQIMACLQMIHIILTKPSPHSDLSDQAIFEKNSKML NDFGIYFPFAFSDFQKKTNKAFFGQRRLI*" /label="yhcU CDS" gene 897212..897607 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /label="yhcU gene" misc_feature complement(897638..897657) /Source="Nicolas_upshift_promotors" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(897652) /Source="Nicolas_upshifts" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 897692..897698 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 897707 /Source="Nicolas_upshifts" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 897712..897723 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(897722..897736) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(897736) /Source="Nicolas_upshifts" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(897744..897748) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 897744..898166 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CBS containing enzyme (sporulation-/ germination-related)" /protein_id="NP_388804.1" /db_xref="EnsemblGenomes-Gn:BSU09230" /db_xref="EnsemblGenomes-Tr:CAB12751" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG11600" /db_xref="UniProtKB/Swiss-Prot:P54606" /translation="MSSVKDTMTTQVATVSPNQTIQEAASLMKQHNVGAIPVVEQGVL KGMLTDRDIALRTTAQGRDGQTPVSEVMSTELVSGNPNMSLEDASQLMAQHQIRRLPI VDQNNLVGIVALGDLAVNQMSNESAGSALTNISHQNIH*" /label="yhcV CDS" gene 897744..898166 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /label="yhcV gene" promotor_no_box complement(898070..898170) /Source="Nicolas_upshift_promotors" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(898110) /Source="Nicolas_upshifts" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 898144 /Source="Nicolas_upshifts" /id="D476" /incds=0 /nref=50 /ntot=61 /MaxReadThrough="2.62549" /MaxDrop="7.03747" /score="-2.59023198" /energy="-12.1" /TU="NA" /idTUdmin="U723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(898176) /Source="Nicolas_upshifts" /id="D477" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="0.0992700000000006" /MaxDrop="3.96142" /score="-9.32793172" /energy="-9.1" /TU="NA" /idTUdmin="U724" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" promotor_-35 898216..898223 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 898237..898256 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 898245 /Source="Nicolas_upshifts" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="upshifts" CDS 898293..898955 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /EC_number="3.1.3.18" /EC_number="3.1.3.68" /EC_number="3.1.3.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16990279, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphoglycolate phosphatase / glycerol-3-phosphate phosphatase / 2-deoxyglucose-6-phosphatase" /protein_id="NP_388805.1" /db_xref="EnsemblGenomes-Gn:BSU09240" /db_xref="EnsemblGenomes-Tr:CAB12752" /db_xref="GOA:P54607" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11601" /db_xref="UniProtKB/Swiss-Prot:P54607" /translation="MIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVI GTAAGFRPFEYLEEQIGKKLNHEELTQLRRERFAKRMESEKARPGVEAYLNAAKDLGL KIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAAKNLGVSPAE CLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNS QN*" /label="glpW CDS" gene 898293..898955 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /label="glpW gene" CDS 898971..900512 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /EC_number="3.5.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26337367, 26808445, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388806.2" /db_xref="EnsemblGenomes-Gn:BSU09250" /db_xref="EnsemblGenomes-Tr:CAB12753" /db_xref="GOA:P54608" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR001110" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG11602" /db_xref="UniProtKB/Swiss-Prot:P54608" /translation="MSEKLDLTRFEKKMVIRNIEEKDIDKIIDLQKDCFPGMEPWKRE HLISHLEHFPEGQFCAEFEGEIIGSCSSLLINFDEYDDRHTWQDITDDGYITNHNPDG LNMYGIEVMVHPKYRRMKIGHRLYEARKDLARRLNLKSIIIGGRIPNYHKYAEEMTAR EYVEQVTRHQIYDPVLSFQLMNGFTLMRINPNYLPDDTASIKYATLMEWNNVDYLPQQ TKRYYKSAFPVRICVIQYEMKKIYSFEEFANQVEYYVDVASDARSDFAVFPEIFTTQL MSFLEERSPSLAVQRITEYTEDYISLFTDLAVKYNVNIIGGSHFVEEEGKIYNIAYLF RRDGTIEKQYKLHITPNERKWWGISAGDQVRVFDTDCGKIAIQICYDIEFPELARIAA DKGAKIIFTPFCTEDRQGYLRVRYCSQARAVENQIYTVISGTVGNLPQTENMDIQYAQ SGIFAPSDFEFARDGIVGETNPNIEMVVIGDVDLEILRRQRQNGTVRQLKDRRRDIYH IQYKK*" /label="yhcX CDS" gene 898971..900512 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /label="yhcX gene" downshifts 900495 /Source="Nicolas_upshifts" /id="D478" /incds=0 /nref=57 /ntot=238 /MaxReadThrough="4.24486" /MaxDrop="5.06754" /score="24.7413026" /energy="-10.5" /TU="U726" /idTUdmin="U726" /TUdmin="-224" /isTUend="FALSE" /label="downshifts" CDS 900596..900787 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52585.1" /translation="MYSGCALWSFCIFAISYIIQKTARLHIAIAMAVQVVSSATFIST MLSIVTLPVLLWKLHPLSS*" /label="yhzG CDS" gene 900596..900787 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /pseudo /label="yhzG gene" promotor_-35 900818..900825 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-35" promotor_-10 900840..900859 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-10" S_feature 900851..900932 /Source="Nicolas_S_feature" /locus_tag="new_1000282_1000363" /HighExp="M40t90, M0t90, T0.30H, LBGstat, BC, Lbstat, M9-stat, Lbtran, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S320" upshifts 900851 /Source="Nicolas_upshifts" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="upshifts" CDS 900933..902285 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11082195, 23610425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase" /protein_id="NP_388807.2" /db_xref="EnsemblGenomes-Gn:BSU09260" /db_xref="EnsemblGenomes-Tr:CAB12754" /db_xref="GOA:P33189" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10184" /db_xref="UniProtKB/Swiss-Prot:P33189" /translation="MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGA WVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEK LNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGAL SATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGV IMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKP DIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNL QIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADA AKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI *" /label="yhxA CDS" gene 900933..902285 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /label="yhxA gene" CDS 902313..902891 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11929549, 23610425, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 23610425, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate responding transcriptionantiterminator" /protein_id="NP_388808.1" /db_xref="EnsemblGenomes-Gn:BSU09270" /db_xref="EnsemblGenomes-Tr:CAB12755" /db_xref="GOA:P30300" /db_xref="InterPro:IPR006699" /db_xref="InterPro:IPR035928" /db_xref="SubtiList:BG10185" /db_xref="UniProtKB/Swiss-Prot:P30300" /translation="MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVI KEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAI QRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEE DVEQALKAGAVAVTTSNTKLWKKYENFLTESD*" /label="glpP CDS" gene 902313..902891 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /label="glpP gene" promotor_-35 902886..902893 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 902908..902927 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 902919 /Source="Nicolas_upshifts" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" downshifts 902934 /Source="Nicolas_upshifts" /id="D479" /incds=0 /nref=3 /ntot=39 /MaxReadThrough="8.20986" /MaxDrop="2.99328" /score="6.07464219" /energy="-10" /TU="U727,U728" /idTUdmin="U726" /TUdmin=2215 /isTUend="FALSE" /label="downshifts" S_feature 902979..903069 /Source="Nicolas_S_feature" /locus_tag="new_1002410_1002500" /HighExp="Diami, T0.30H, G150, Oxctl, Gly, Paraq, dia5, BC, B60, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S321" CDS 903070..903894 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycerol permease" /protein_id="NP_388809.1" /db_xref="EnsemblGenomes-Gn:BSU09280" /db_xref="EnsemblGenomes-Tr:CAB12756" /db_xref="GOA:P18156" /db_xref="InterPro:IPR000425" /db_xref="InterPro:IPR022357" /db_xref="InterPro:IPR023271" /db_xref="SubtiList:BG10186" /db_xref="UniProtKB/Swiss-Prot:P18156" /translation="MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGW GLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYL HYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGL NPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVG PILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI*" /label="glpF CDS" gene 903070..903894 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /label="glpF gene" CDS 903913..905403 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /EC_number="2.7.1.30" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9972264, 10920256, 11929549, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol kinase (sn-glycerol-3-phosphate generating)" /protein_id="NP_388810.2" /db_xref="EnsemblGenomes-Gn:BSU09290" /db_xref="EnsemblGenomes-Tr:CAB12757" /db_xref="GOA:P18157" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005999" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10187" /db_xref="UniProtKB/Swiss-Prot:P18157" /translation="METYILSLDQGTTSSRAILFNKEGKIVHSAQKEFTQYFPHPGWV EHNANEIWGSVLAVIASVISESGISASQIAGIGITNQRETTVVWDKDTGSPVYNAIVW QSRQTSGICEELREKGYNDKFREKTGLLIDPYFSGTKVKWILDNVEGAREKAEKGELL FGTIDTWLIWKMSGGKAHVTDYSNASRTLMFNIYDLKWDDELLDILGVPKSMLPEVKP SSHVYAETVDYHFFGKNIPIAGAAGDQQSALFGQACFEEGMGKNTYGTGCFMLMNTGE KAIKSEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGLRMFQDSSLSESYAEK VDSTDGVYVVPAFVGLGTPYWDSDVRGSVFGLTRGTTKEHFIRATLESLAYQTKDVLD AMEADSNISLKTLRVDGGAVKNNFLMQFQGDLLNVPVERPEINETTALGAAYLAGIAV GFWKDRSEIANQWNLDKRFEPELEEEKRNELYKGWQKAVKAAMAFK*" /label="glpK CDS" gene 903913..905403 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /label="glpK gene" promotor_-35 904714..904720 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 904735..904754 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-10" upshifts 904745 /Source="Nicolas_upshifts" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="upshifts" S_feature 905404..905492 /Source="Nicolas_S_feature" /locus_tag="new_1004835_1004923" /HighExp="Sw, Etha, Salt, G150, Gly, Diami, T0.30H, B60, BC, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S322" downshifts 905449 /Source="Nicolas_upshifts" /id="D480" /incds=0 /nref=34 /ntot=91 /MaxReadThrough="7.63856" /MaxDrop="5.2045" /score="21.1943866" /energy="-28.7" /TU="U728,U729" /idTUdmin="U727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 905455..905555 /Source="Nicolas_upshift_promotors" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 905515 /Source="Nicolas_upshifts" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" CDS 905544..907211 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /EC_number="1.1.3.21" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2127799, 8825777, 9595668, 10633102, 18946204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2127799, 8825777, 9595668, 10633102, 18946204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate oxidase (FAD-dependent)" /protein_id="NP_388811.2" /db_xref="EnsemblGenomes-Gn:BSU09300" /db_xref="EnsemblGenomes-Tr:CAB12758" /db_xref="GOA:P18158" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR031656" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10188" /db_xref="UniProtKB/Swiss-Prot:P18158" /translation="MMNHQFSSLERDRMLTDMTKKTYDLFIIGGGITGAGTALDAASR GMKVALSEMQDFAAGTSSRSTKLVHGGLRYLKQFEVKMVAEVGKERAIVYENGPHVTT PEWMLLPFHKGGTFGSFTTSIGLRVYDFLAGVKKSERRSMLSAKETLQKEPLVKKDGL KGGGYYVEYRTDDARLTIEVMKEAVKFGAEPVNYSKVKELLYEKGKAVGVLIEDVLTK KEYKVYAKKIVNATGPWVDQLREKDHSKNGKHLQHTKGIHLVFDQSVFPLKQAVYFDT PDGRMVFAIPREGKTYVGTTDTVYKEALEHPRMTTEDRDYVIKSINYMFPELNITAND IESSWAGLRPLIHEEGKDPSEISRKDEIWTSDSGLITIAGGKLTGYRKMAEHIVDLVR DRLKEEGEKDFGPCKTKNMPISGGHVGGSKNLMSFVTAKTKEGIAAGLSEKDAKQLAI RYGSNVDRVFDRVEALKDEAAKRNIPVHILAEAEYSIEEEMTATPADFFVRRTGRLFF DINWVRTYKDAVIDFMSERFQWDEQAKNKHTENLNKLLHDAVVPLEQ*" /label="glpD CDS" gene 905544..907211 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /label="glpD gene" promotor_-35 906973..906978 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 906993..907011 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-10" upshifts 907002 /Source="Nicolas_upshifts" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="upshifts" promotor_-35 907056..907062 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 907077 /Source="Nicolas_upshifts" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 907078..907096 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 907179 /Source="Nicolas_upshifts" /id="D481" /incds=0 /nref=13 /ntot=60 /MaxReadThrough="6.57605" /MaxDrop="4.31183" /score="11.5542287" /energy="-11.4" /TU="U728,U729,U730,U731,U732" /idTUdmin="U729" /TUdmin="-118" /isTUend="FALSE" /label="downshifts" S_feature 907224..907297 /Source="Nicolas_S_feature" /locus_tag="new_1006655_1006728" /HighExp="G150, Etha, Oxctl, H2O2, Gly, Diami, Paraq, Salt, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF, Sig-, SigB, SigA" /TUshortPSig="1, 0.995, 0.155, 1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S323" promotor_-35 907279..907286 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 907299 /Source="Nicolas_upshifts" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 907300..907319 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 907343..909088 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /EC_number="5.4.2.2" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15640167, 17662947, 24097947, 26735940, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15640167, 17662947, 24097947, 26735940, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-phosphoglucomutase" /protein_id="NP_388812.2" /db_xref="EnsemblGenomes-Gn:BSU09310" /db_xref="EnsemblGenomes-Tr:CAB12759" /db_xref="GOA:P18159" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG10189" /db_xref="UniProtKB/Swiss-Prot:P18159" /translation="MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEF GTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFA MEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSI SVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSP NPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLH YLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEA SGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNE YGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTE SKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSE DVMKTVDEIVESTAK*" /label="pgcA CDS" gene 907343..909088 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /label="pgcA gene" downshifts 909077 /Source="Nicolas_upshifts" /id="D482" /incds=0 /nref=227 /ntot=264 /MaxReadThrough="4.80136" /MaxDrop="5.89896" /score="26.7163878" /energy="-13" /TU="U732,U733" /idTUdmin="U728" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" S_feature 909122..909191 /Source="Nicolas_S_feature" /locus_tag="new_1008553_1008622" /HighExp="Etha, H2O2, B36, dia15, Paraq, G150, LoTm, S8, Oxctl, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S324" misc_feature 909193..909212 /Source="Nicolas_upshift_promotors" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 909193 /Source="Nicolas_upshifts" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" CDS 909237..910376 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YhcZ]" /protein_id="NP_388813.1" /db_xref="EnsemblGenomes-Gn:BSU09320" /db_xref="EnsemblGenomes-Tr:CAB12760" /db_xref="GOA:O07527" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13005" /db_xref="UniProtKB/Swiss-Prot:O07527" /translation="MSKTRMEKLKTLKTIAETLNQGHDIKATLDEVLKELLSLTNLQS GWIFLIEEDGSYTLAADAYLPPALSRKEKVLMCEGECYCLTKFNNGGLRKAANIMNCK RIESAENLHCFDTEGITHHATVPLEDGDRRFGLLNVAAAGKTMFDEEELHLLESVAFQ IGTAIQRMRLSEYQQKNALLMERNRLAQELHDSVNQMLFSVSLTAKAAKTLTKDENLQ QMIDFIQNLSQDALAEMKALIWQLRPGGLEKGLAEAIKSYGALIGLKIIFTQKGCPVL TDEQEHMLWRVVQEALNNCKKHAGTDTAYVSLTASLCHAELDIIDHGAGFRYEAHAGL PSLGIKGMKERAEKAGAKFWIESALGTGTKLSIRLPLKSRKGGAV*" /label="yhcY CDS" gene 909237..910376 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /label="yhcY gene" CDS 910373..911017 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YhcY]" /protein_id="NP_388814.1" /db_xref="EnsemblGenomes-Gn:BSU09330" /db_xref="EnsemblGenomes-Tr:CAB12761" /db_xref="GOA:O07528" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13006" /db_xref="UniProtKB/Swiss-Prot:O07528" /translation="MKIVIADDHHVVRKGLRFFFATQDDIEVVGEAATGLEALRVIEE TKPDLVLMDLSMPEMDGIQAIKKAIQQFPDTNIIVLTSYSDQEHVIPALQAGAKAYQL KDTEPEELVKTRQVHGGEYKLSTAIMPHVLTHMKNQHDPEKEKYYQLTRREKDVLTEI ANGKSNKEIAAALFISEKTVKTHVSNLLAKLEVADRTQAALFAVKYNLNGEISK*" /label="yhcZ CDS" gene 910373..911017 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /label="yhcZ gene" CDS 911014..911538 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /EC_number="1.7.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15184374, 16816187, 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidoreductase, NAD(P)H-FMN and ferric iron reductase (azoreductase)" /protein_id="NP_388815.1" /db_xref="EnsemblGenomes-Gn:BSU09340" /db_xref="EnsemblGenomes-Tr:CAB12762" /db_xref="GOA:O07529" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1NNI" /db_xref="PDB:2GSW" /db_xref="PDB:3GFQ" /db_xref="PDB:3GFR" /db_xref="PDB:3GFS" /db_xref="SubtiList:BG13007" /db_xref="UniProtKB/Swiss-Prot:O07529" /translation="MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNG EAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALL AVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELV EELSMFAKAGNPGV*" /label="azr CDS" gene 911014..911538 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /label="azr gene" downshifts 911503 /Source="Nicolas_upshifts" /id="D483" /incds=0 /nref=72 /ntot=215 /MaxReadThrough="2.90096" /MaxDrop="4.78561" /score="27.1269177" /energy="-17.2" /TU="NA" /idTUdmin="U734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(911553..911795) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388816.1" /db_xref="EnsemblGenomes-Gn:BSU09350" /db_xref="EnsemblGenomes-Tr:CAB12763" /db_xref="InterPro:IPR025431" /db_xref="SubtiList:BG13008" /db_xref="UniProtKB/Swiss-Prot:O07530" /translation="MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAY HFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT*" /label="yhdB CDS" gene complement(911553..911795) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /label="yhdB gene" downshifts complement(911574) /Source="Nicolas_upshifts" /id="D484" /incds=0 /nref=39 /ntot=84 /MaxReadThrough="-0.0235599999999998" /MaxDrop="7.78706" /score="12.0066876" /energy="-17.2" /TU="NA" /idTUdmin="U735" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(911831..911842) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(911842) /Source="Nicolas_upshifts" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(911856..911863) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 911930..911936 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 911950..911961 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 911960 /Source="Nicolas_upshifts" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="upshifts" CDS 911996..912319 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388817.1" /db_xref="EnsemblGenomes-Gn:BSU09360" /db_xref="EnsemblGenomes-Tr:CAB12764" /db_xref="InterPro:IPR024987" /db_xref="SubtiList:BG13009" /db_xref="UniProtKB/Swiss-Prot:O07531" /translation="MKSLPYTIALLFCGLIIVSMAAKGHSTDTDESVQKWEQLAWSKI QDEYKGASFSDYAYMGRTEVNDQQTKDVFRVTVRQKDDTFSVRAEVYFHPVTNHMISI NVFRL*" /label="yhdC CDS" gene 911996..912319 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /label="yhdC gene" S_feature 912320..914186 /Source="Nicolas_S_feature" /locus_tag="new_1011751_1013617" /HighExp="S8, S5, S7, S6, S4, C30, Sw, ferm, S3, BC" /AntisenseName="lytF" /AntisenseCor="-0.65564579825076796" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S325" CDS complement(912361..913827) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10206711, 14594841, 18761694, 18761696, 23091053, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10206711, 14594841, 18761694, 18761696, 23091053, 25288647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)" /protein_id="NP_388818.2" /db_xref="EnsemblGenomes-Gn:BSU09370" /db_xref="EnsemblGenomes-Tr:CAB12776" /db_xref="GOA:O07532" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13010" /db_xref="UniProtKB/Swiss-Prot:O07532" /translation="MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTY NTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSL WLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSK SSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTK SSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLY VGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREK NNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGG TTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHV GIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF*" /label="lytF CDS" gene complement(912361..913827) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /label="lytF gene" downshifts complement(912373) /Source="Nicolas_upshifts" /id="D485" /incds=0 /nref=121 /ntot=216 /MaxReadThrough="2.34529" /MaxDrop="4.33563" /score="24.6732339" /energy="-14.2" /TU="NA" /idTUdmin="U737" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(912460) /Source="Nicolas_upshifts" /id="D486" /incds=1 /nref=1 /ntot=87 /MaxReadThrough="5.73069" /MaxDrop="2.6306" /score="24.6732339" /energy="-14.2" /TU="U737" /idTUdmin="U737" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(913867..913885) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(913879) /Source="Nicolas_upshifts" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(913899..913906) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(913980..914420) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033; Product type r: regulator" /codon_start=1 /transl_table=11 /product="NO-dependent activator of the ResDE regulon (Fe-S NO binding site)" /protein_id="NP_388819.1" /db_xref="EnsemblGenomes-Gn:BSU09380" /db_xref="EnsemblGenomes-Tr:CAB12777" /db_xref="GOA:O07573" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13011" /db_xref="UniProtKB/Swiss-Prot:O07573" /translation="MKLTNYTDYSLRVLIFLAAERPGELSNIKQIAETYSISKNHLMK VIYRLGQLGYVETIRGRGGGIRLGMDPEDINIGEVVRKTEDDFNIVECFDANKNLCVI SPVCGLKHVLNEALLAYLAVLDKYTLRDLVKNKEDIMKLLKMKE*" /label="nsrR CDS" gene complement(913980..914420) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /label="nsrR gene" downshifts complement(914010) /Source="Nicolas_upshifts" /id="D487" /incds=0 /nref=205 /ntot=265 /MaxReadThrough="3.11158" /MaxDrop="6.87147" /score="5.96186156" /energy="-7.8" /TU="U739" /idTUdmin="U740" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" promotor_-35 914408..914414 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 914428..914439 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 914430..914540 /Source="Nicolas_S_feature" /locus_tag="new_1013861_1013971" /HighExp="S8, S7, S4, Sw, S5, S6, BC, B60, nit, Pyr" /AntisenseName="ygxB" /AntisenseCor="-0.211236686077168" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.904" /TUlongSig="NA" /TUlongPSig="NA" /label="S326" upshifts 914430 /Source="Nicolas_upshifts" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(914442..914461) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(914458) /Source="Nicolas_upshifts" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(914473..914479) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 914499 /Source="Nicolas_upshifts" /id="D488" /incds=0 /nref=10 /ntot=68 /MaxReadThrough="1.05981" /MaxDrop="6.25571" /score="22.5171081" /energy="-11.6" /TU="NA" /idTUdmin="U738" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(914527..916185) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388820.1" /db_xref="EnsemblGenomes-Gn:BSU09390" /db_xref="EnsemblGenomes-Tr:CAB12778" /db_xref="GOA:P37874" /db_xref="InterPro:IPR008910" /db_xref="SubtiList:BG10181" /db_xref="UniProtKB/Swiss-Prot:P37874" /translation="MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQ LNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPS RYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLIL LLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVF LPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLAS IGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSML NTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLS LSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAG ELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFA LAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM*" /label="ygxB CDS" gene complement(914527..916185) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /label="ygxB gene" downshifts complement(914532) /Source="Nicolas_upshifts" /id="D489" /incds=0 /nref=6 /ntot=40 /MaxReadThrough="8.34865" /MaxDrop="5.55332" /score="-5.46969987" /energy="-14.5" /TU="U740" /idTUdmin="U740" /TUdmin="-532" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(916076..916094) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(916096) /Source="Nicolas_upshifts" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(916108..916114) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 916157..916162 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 916178..916196 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 916191 /Source="Nicolas_upshifts" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="upshifts" CDS 916216..917622 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8144469, 14680823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8144469, 14680823; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria" /protein_id="NP_388821.1" /db_xref="EnsemblGenomes-Gn:BSU09400" /db_xref="EnsemblGenomes-Tr:CAB12779" /db_xref="GOA:P37875" /db_xref="InterPro:IPR007390" /db_xref="SubtiList:BG10182" /db_xref="UniProtKB/Swiss-Prot:P37875" /translation="MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFG AYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYELVINSDPCYAFLLDSNSLIQNKLIV AHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQE HIDPSLVRPKLQWSVDDEEEEIEEAATPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKD ILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLT SDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGRE KMFEVREIESDISFIRNYLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRV NGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEKVLPYLFQLWGRSVHIESVLE DKEVMFSYDGKGVHRRYL*" /label="spoVR CDS" gene 916216..917622 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /label="spoVR gene" downshifts 917602 /Source="Nicolas_upshifts" /id="D490" /incds=0 /nref=43 /ntot=84 /MaxReadThrough="1.30719" /MaxDrop="6.74388" /score="26.4488835" /energy="-11.5" /TU="NA" /idTUdmin="U741" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(917652..919037) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8830275, 10913081, 12897025, 16491025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830275, 10913081, 12897025, 16491025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase A" /protein_id="NP_388822.2" /db_xref="EnsemblGenomes-Gn:BSU09410" /db_xref="EnsemblGenomes-Tr:CAB12780" /db_xref="GOA:P19406" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10183" /db_xref="UniProtKB/Swiss-Prot:P19406" /translation="MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQ DKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPD YNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHA TPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQA GYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKG FFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGG FTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEA AAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQA NIIFKILKTGK*" /label="phoA CDS" gene complement(917652..919037) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /label="phoA gene" downshifts complement(917678) /Source="Nicolas_upshifts" /id="D491" /incds=0 /nref=51 /ntot=178 /MaxReadThrough="1.90638" /MaxDrop="5.795" /score="22.2126775" /energy="-13.2" /TU="NA" /idTUdmin="U742" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(919064) /Source="Nicolas_upshifts" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(919066..920597) /Source="Nicolas_S_feature" /locus_tag="new_1018497_1020028_c" /HighExp="Etha, Salt, B60, Heat, M9-stat, T5.0H, T0.30H, T4.0H, T3.30H, T2.30H" /AntisenseName="lytE" /AntisenseCor="-0.65081062481616203" /AntisenseRegPval="-33.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="0.966, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S327" misc_feature complement(919074..919085) /Source="Nicolas_upshift_promotors" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 919193..919200 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 919213..919232 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 919219..919506 /Source="Nicolas_S_feature" /locus_tag="new_1018650_1018937" /HighExp="T-5.40H, Cold, LoTm, T-4.40H, UNK1, T5.0H, GM-0.1, T3.30H, S1, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S328" upshifts 919219 /Source="Nicolas_upshifts" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 919469..919472 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 919487..919506 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 919508 /Source="Nicolas_upshifts" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="upshifts" CDS 919567..920571 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 16950129, 9457885, 21541672, 22139507, 27002131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)" /protein_id="NP_388823.2" /db_xref="EnsemblGenomes-Gn:BSU09420" /db_xref="EnsemblGenomes-Tr:CAB12781" /db_xref="GOA:P54421" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11406" /db_xref="UniProtKB/Swiss-Prot:P54421" /translation="MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYD TTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKK YGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLS KIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSL NVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSI ASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF *" /label="lytE CDS" gene 919567..920571 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /label="lytE gene" downshifts 920433 /Source="Nicolas_upshifts" /id="D492" /incds=1 /nref=1 /ntot=117 /MaxReadThrough="6.89938" /MaxDrop="2.1687" /score="26.3320532" /energy="-9.8" /TU="U743,U744" /idTUdmin="U743" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 920563 /Source="Nicolas_upshifts" /id="D493" /incds=0 /nref=53 /ntot=190 /MaxReadThrough="3.64545" /MaxDrop="6.08377" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" upshifts complement(920597) /Source="Nicolas_upshifts" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(920604..920619) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 920609 /Source="Nicolas_upshifts" /id="D494" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="2.99" /MaxDrop="3.76174" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(920631..920640) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(920642..921517) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8045899, 10869065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045899, 10869065; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator CitR (LysR family)" /protein_id="NP_388824.2" /db_xref="EnsemblGenomes-Gn:BSU09430" /db_xref="EnsemblGenomes-Tr:CAB12782" /db_xref="GOA:P39127" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10853" /db_xref="UniProtKB/Swiss-Prot:P39127" /translation="MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEIS CKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIA DTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCL YKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTM KVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYEN KKEKKFLDFLSHFHF*" /label="citR CDS" gene complement(920642..921517) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /label="citR gene" promotor_-35 921570..921571 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(921583..921602) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-10" promotor_-10 921588..921607 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(921589) /Source="Nicolas_upshifts" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="upshifts" upshifts 921598 /Source="Nicolas_upshifts" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(921617..921622) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-35" CDS 921626..922726 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:4211224, 8045898, 8045899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4211224, 8045898, 8045899; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase I" /protein_id="NP_388825.2" /db_xref="EnsemblGenomes-Gn:BSU09440" /db_xref="EnsemblGenomes-Tr:CAB12783" /db_xref="GOA:P39119" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR016143" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="PDB:2C6X" /db_xref="SubtiList:BG10854" /db_xref="UniProtKB/Swiss-Prot:P39119" /translation="MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEE AAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALG ENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQP SEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPS AVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGND RDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMV GWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS*" /label="citA CDS" gene 921626..922726 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /label="citA gene" promotor_-35 922737..922743 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 922758..922776 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 922763 /Source="Nicolas_upshifts" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 922800..923669 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 18643936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)-dependent dehydrogenase" /protein_id="NP_388826.1" /db_xref="EnsemblGenomes-Gn:BSU09450" /db_xref="EnsemblGenomes-Tr:CAB12784" /db_xref="GOA:O07575" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13012" /db_xref="UniProtKB/Swiss-Prot:O07575" /translation="MNPMDRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLK GKVAIITGGDSGIGRAAAIAFAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPG DVGDENHCEQAVQQTVDHFGKLDILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMF HMTKKALPHLQEGCAIINTTSITAYEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIR VNAVAPGPIWTPLIPATFPEEKVKQHGLDTPMGRPGQPVEHAGAYVLLASDESSYMTG QTIHVNGGRFIST*" /label="yhdF CDS" gene 922800..923669 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /label="yhdF gene" downshifts 923677 /Source="Nicolas_upshifts" /id="D495" /incds=0 /nref=27 /ntot=130 /MaxReadThrough="8.65426" /MaxDrop="6.48064" /score="18.1511963" /energy="-8.2" /TU="U748" /idTUdmin="U747" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 923754..923757 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 923769 /Source="Nicolas_upshifts" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 923772..923791 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 923817..923836 /Source="Nicolas_upshift_promotors" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 923822..923918 /Source="Nicolas_S_feature" /locus_tag="new_1023253_1023349" /HighExp="Etha, T2.30H, T-0.40H, T2.0H, T1.30H, S1, GM-0.2, T3.0H, T-1.40H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.27332800000000002" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.522, 0.998, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S329" upshifts 923822 /Source="Nicolas_upshifts" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" CDS 923919..925316 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16621821, 16850406, 21097623, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16621821, 16850406, 21097623, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid transporter or methylthioribose-degradation metabolite exporter" /protein_id="NP_388827.1" /db_xref="EnsemblGenomes-Gn:BSU09460" /db_xref="EnsemblGenomes-Tr:CAB12785" /db_xref="GOA:O07576" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004758" /db_xref="SubtiList:BG13013" /db_xref="UniProtKB/Swiss-Prot:O07576" /translation="MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGT GIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYAEFASSVPVSGSVYTFTYATLGE LMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMP MGFGGVFSAAALVFFAFIGFDAVSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAI MTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTVMLVMLYGQTRVMFA MSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVL ISVAVIVLRKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGL VIYFLYSRKHSKLNQ*" /label="bcaP CDS" gene 923919..925316 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /label="bcaP gene" downshifts 925296 /Source="Nicolas_upshifts" /id="D496" /incds=0 /nref=116 /ntot=188 /MaxReadThrough="3.41176" /MaxDrop="5.29633" /score="5.08283681" /energy="-12.3" /TU="U748,U749" /idTUdmin="U750" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 925377..925381 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 925397..925416 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 925404 /Source="Nicolas_upshifts" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 925434..926789 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_388828.1" /db_xref="EnsemblGenomes-Gn:BSU09470" /db_xref="EnsemblGenomes-Tr:CAB12786" /db_xref="GOA:O07577" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13014" /db_xref="UniProtKB/Swiss-Prot:O07577" /translation="MSEQKPVQWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAF FLIFVLFTILLGYPLLVGEFIFGRRNQTNAIDAYKKEAPRSAWFLTGWIGVAACFLVL SFYSVIGGWILLYIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLV VARGVQKGIERVSAVMMPILFLLFILLVLRSLTLNGAMEGVKFLLVPHFGDLTPESIL FALGQAFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIFPAVFS FGFQPNEGPTLLFTVLPAVFEQLPFGTLFFIGFLVAFLFAALTSAFSMVEIIVATIGK GDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADFTVSNVLMPSGA LLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIVFLNLIGILS F*" /label="yhdH CDS" gene 925434..926789 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /label="yhdH gene" downshifts 926770 /Source="Nicolas_upshifts" /id="D497" /incds=0 /nref=184 /ntot=244 /MaxReadThrough="1.73756" /MaxDrop="6.09379" /score="40.1809389" /energy="-14.8" /TU="NA" /idTUdmin="U751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(926824..928233) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388829.1" /db_xref="EnsemblGenomes-Gn:BSU09480" /db_xref="EnsemblGenomes-Tr:CAB12787" /db_xref="GOA:O07578" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13015" /db_xref="UniProtKB/Swiss-Prot:O07578" /translation="MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRL SSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQ KNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFV RLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVT PICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIED DYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNV QLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILG KNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEED IRLGIQKLKTAWAPLISSY*" /label="yhdI CDS" gene complement(926824..928233) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /label="yhdI gene" promotor_-35 928282..928285 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 928300..928319 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 928302 /Source="Nicolas_upshifts" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(928304..928323) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(928316) /Source="Nicolas_upshifts" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(928339..928343) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 928343..928771 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388830.1" /db_xref="EnsemblGenomes-Gn:BSU09490" /db_xref="EnsemblGenomes-Tr:CAB12788" /db_xref="GOA:O07579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13016" /db_xref="UniProtKB/Swiss-Prot:O07579" /translation="MIHMKQLTSKEEWAESYPIMSELRTELDIETYLQRLEACVQKES YMLFALYENTAIRALCGALPRVSIHKGEHLWIADLVTTAPCRSKGYGKMLLDYASDWA RKAGLGFVSLSSGLQRKDAHRFYTDKMGFTIESYLFRKPV*" /label="yhdJ CDS" gene 928343..928771 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /label="yhdJ gene" downshifts 928750 /Source="Nicolas_upshifts" /id="D498" /incds=0 /nref=46 /ntot=213 /MaxReadThrough="1.42962" /MaxDrop="4.77191" /score="24.6412105" /energy="-12.1" /TU="NA" /idTUdmin="U752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(928802..929092) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388831.1" /db_xref="EnsemblGenomes-Gn:BSU09500" /db_xref="EnsemblGenomes-Tr:CAB12789" /db_xref="GOA:O07580" /db_xref="InterPro:IPR020496" /db_xref="SubtiList:BG13017" /db_xref="UniProtKB/Swiss-Prot:O07580" /translation="MELVRIFKEHNVFGWISVGTAVLSLLLLNLAIISNVTFYSYQML PFAMAAVPFGVVELFIKRGRTGPGLLGVILNLFVIICVYTIVSVDTNLQFGF*" /label="asiMB CDS" gene complement(928802..929092) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /label="asiMB gene" downshifts complement(928826) /Source="Nicolas_upshifts" /id="D499" /incds=0 /nref=44 /ntot=229 /MaxReadThrough="2.66153" /MaxDrop="4.72865" /score="26.7359231" /energy="-11.1" /TU="NA" /idTUdmin="U754" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(929080..930156) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388832.1" /db_xref="EnsemblGenomes-Gn:BSU09510" /db_xref="EnsemblGenomes-Tr:CAB12790" /db_xref="GOA:O07581" /db_xref="InterPro:IPR025672" /db_xref="InterPro:IPR029101" /db_xref="SubtiList:BG13018" /db_xref="UniProtKB/Swiss-Prot:O07581" /translation="MMNEEFKKRFDQYKNGEMSDQEMTAFEEELEKLEVYQELIDSEL EDDNDWDLSISPEKQKAILAYGKRKSYLRISVLAVISTLMILPLCTLGSYLYYGMGGK HSTGNEFMETAAVTVALTMPNVLVDTSGLKSQVKLFGMNTEFPLQKQIGTKTAAVGNE RVEMFYNKVKAPAVNYYDLEVNKTGHYFTHPSNKSEQTTAKAEKTLSTLPEGTVSEVY LSYDRAYPTKDVYNKFKGYDVSFLWNAIETEKNTNKTASTEPLGYPGKDSKFLAALNT KGKSNGDQFINALKFMSKHEKWAQVISKRKDLNVDNRLDYVEKNGVNVYGSVVTGPTK EIQRMLKNKSVKSANVGEVELWNW*" /label="asiMA CDS" gene complement(929080..930156) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /label="asiMA gene" CDS complement(930146..930637) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14651641, 14769884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))" /protein_id="NP_388833.1" /db_xref="EnsemblGenomes-Gn:BSU09520" /db_xref="EnsemblGenomes-Tr:CAB12791" /db_xref="GOA:O07582" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13019" /db_xref="UniProtKB/Swiss-Prot:O07582" /translation="MTIDEIYQMYMNDVYRFLLSMTKDKHLAEDLLQETFMRAYIHIH SYDHSKVKPWLFQVARNAFIDYVRKHKKEVTISDDLIGSLFQNAVQSPAHQVEIKEVL TGYMSELPDNYREALTLYYLKELNYKEASHIMNISEANFKSVLFRARQRLKALYNRGV NDE*" /label="sigM CDS" gene complement(930146..930637) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /label="sigM gene" S_feature complement(930638..930740) /Source="Nicolas_S_feature" /locus_tag="new_1030069_1030171_c" /HighExp="Cold, LBGstat, H2O2, G180, Paraq, Oxctl, G135, HPh, dia15, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S330" promotor_-10 complement(930729..930748) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(930740) /Source="Nicolas_upshifts" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(930762..930765) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 930778..930784 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 930795 /Source="Nicolas_upshifts" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 930799..930817 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(930828) /Source="Nicolas_upshifts" /id="D500" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="2.13683" /MaxDrop="4.59517" /score="8.96845329" /energy="-10.2" /TU="NA" /idTUdmin="U757" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS 930834..931829 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10220166, 15019785, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15019785, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldo/keto reductase specific for NADPH; protectsagainst methylglyoxal" /protein_id="NP_388834.1" /db_xref="EnsemblGenomes-Gn:BSU09530" /db_xref="EnsemblGenomes-Tr:CAB12792" /db_xref="GOA:P80874" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PZ1" /db_xref="SubtiList:BG13020" /db_xref="UniProtKB/Swiss-Prot:P80874" /translation="MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAAL DQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRAR IVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIE QMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEE YTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADI ALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI*" /label="akrN CDS" gene 930834..931829 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /label="akrN gene" downshifts 931808 /Source="Nicolas_upshifts" /id="D501" /incds=0 /nref=59 /ntot=160 /MaxReadThrough="6.85446" /MaxDrop="4.90106" /score="10.4379759" /energy="-11.8" /TU="U755" /idTUdmin="U756" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 931891..931894 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 931909..931928 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 931914 /Source="Nicolas_upshifts" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="upshifts" CDS 931964..932563 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /EC_number="2.3.1.51" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1557036, 17557823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1557036, 17557823; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase" /protein_id="NP_388835.1" /db_xref="EnsemblGenomes-Gn:BSU09540" /db_xref="EnsemblGenomes-Tr:CAB12793" /db_xref="GOA:O07584" /db_xref="InterPro:IPR002123" /db_xref="InterPro:IPR004552" /db_xref="SubtiList:BG13021" /db_xref="UniProtKB/Swiss-Prot:O07584" /translation="MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVD VITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKE GEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLII GEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL*" /label="plsC CDS" gene 931964..932563 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /label="plsC gene" downshifts 932578 /Source="Nicolas_upshifts" /id="D502" /incds=0 /nref=189 /ntot=245 /MaxReadThrough="6.36101" /MaxDrop="7.07164" /score="-7.3088084" /energy="-6.1" /TU="U755" /idTUdmin="U756" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 932623..934577 /Source="Nicolas_S_feature" /locus_tag="new_1032054_1034008" /HighExp="Cold, C30, S8, T-4.40H, Sw, Fru, S0, S7, HPh, G135" /AntisenseName="yhdP" /AntisenseCor="-0.46228251493795502" /AntisenseRegPval="-14.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S331" CDS complement(932632..933966) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /function="16.1: Circulate" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 25182490; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative magnesium efflux pump" /protein_id="NP_388836.1" /db_xref="EnsemblGenomes-Gn:BSU09550" /db_xref="EnsemblGenomes-Tr:CAB12794" /db_xref="GOA:O07585" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13022" /db_xref="UniProtKB/Swiss-Prot:O07585" /translation="MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKA AIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVI SFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSA RLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKE IMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISG EVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDII EEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWF LTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA*" /label="yhdP CDS" gene complement(932632..933966) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /label="yhdP gene" downshifts complement(932651) /Source="Nicolas_upshifts" /id="D503" /incds=0 /nref=284 /ntot=315 /MaxReadThrough="1.96991" /MaxDrop="7.22379" /score="11.1466394" /energy="-9.1" /TU="NA" /idTUdmin="U757" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" CDS complement(934027..934458) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 18048925" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 18048925; Product type r: regulator" /codon_start=1 /transl_table=11 /product="indirect copper efflux transcriptional regulator" /protein_id="NP_388837.1" /db_xref="EnsemblGenomes-Gn:BSU09560" /db_xref="EnsemblGenomes-Tr:CAB12795" /db_xref="GOA:O07586" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13023" /db_xref="UniProtKB/Swiss-Prot:O07586" /translation="MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCS NYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMN QNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS*" /label="cueR CDS" gene complement(934027..934458) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /label="cueR gene" promotor_-10 complement(934470..934489) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(934480) /Source="Nicolas_upshifts" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(934504..934510) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(934506..934606) /Source="Nicolas_upshift_promotors" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 934541..934548 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-35" upshifts complement(934546) /Source="Nicolas_upshifts" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 934562..934581 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-10" upshifts 934579 /Source="Nicolas_upshifts" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="upshifts" CDS 934615..935796 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965, 15103638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_388838.1" /db_xref="EnsemblGenomes-Gn:BSU09570" /db_xref="EnsemblGenomes-Tr:CAB12796" /db_xref="GOA:O07587" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13024" /db_xref="UniProtKB/Swiss-Prot:O07587" /translation="MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSL GNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVM TVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEA VRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQ LIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNR TLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPK SPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDF A*" /label="yhdR CDS" gene 934615..935796 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /label="yhdR gene" downshifts 935781 /Source="Nicolas_upshifts" /id="D504" /incds=0 /nref=12 /ntot=180 /MaxReadThrough="2.81766" /MaxDrop="3.37889" /score="-5.8634451" /energy="-9.1" /TU="U759" /idTUdmin="U759" /TUdmin="-163" /isTUend="FALSE" /label="downshifts" S_feature 935826..935964 /Source="Nicolas_S_feature" /locus_tag="new_1035257_1035395" /HighExp="Etha, S1, BMM, S2, Cold, MG 45, MG 25, C90, T-5.40H, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S332" misc_feature 935960..935979 /Source="Nicolas_upshift_promotors" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 935966..936122 /Source="Nicolas_S_feature" /locus_tag="new_1035397_1035553" /HighExp="M9-stat, B60, T4.0H, T3.0H, LoTm, S5, T5.0H, S4, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S333" upshifts 935966 /Source="Nicolas_upshifts" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="upshifts" CDS 936123..937508 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388840.1" /db_xref="EnsemblGenomes-Gn:BSU09590" /db_xref="EnsemblGenomes-Tr:CAB12798" /db_xref="GOA:O07589" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13026" /db_xref="UniProtKB/Swiss-Prot:O07589" /translation="MDDIDSLILIGVLIALTAFFVASEFAIVRVRRSRIDQLITEGNK RAILARRVITDLDEYLSASQLGITLTSIGLGVLGEPAFERLLHPLFEPLGLPDSVSHA VSFAVAYGLITFLHVVVGELAPKTVAIQKAEQLTLLIAGPLRLFYLLLFPFIWILNGS ARLLCGMFGLKPASEHDGSHSEEELRMLLSESLKNGEINPSEYKYVNKIFEFDNRIAK EIMIPRKEMAAVSTEMTMAEMLEVMLKEKYTRWPVTDGDKDSVLGLVNTKHLFSDLLF MTEEERMKMTIHPYVRPVIEVIETIPVHDLLIKMQRERIHMAILSDEYGGTSGLVTTE DILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMDGKVRIDQVNSLLGASIQEDVDTIGG LILKENIDIEAGESIRIGSYTIKVLKMDGRLIKQIDIKEEAGNTTGITAHHKLPLPEP VMLNSATLSEK*" /label="yhdT CDS" gene 936123..937508 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /label="yhdT gene" downshifts 937398 /Source="Nicolas_upshifts" /id="D505" /incds=1 /nref=120 /ntot=240 /MaxReadThrough="5.11037" /MaxDrop="3.79021" /score="19.6985636" /energy="-10.5" /TU="U760" /idTUdmin="U760" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 937484 /Source="Nicolas_upshifts" /id="D506" /incds=0 /nref=129 /ntot=245 /MaxReadThrough="1.68999" /MaxDrop="6.12682" /score="19.6985636" /energy="-10.5" /TU="NA" /idTUdmin="U760" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(937522..937878) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 17196979, 22194412, 27824896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fluoride efflux channel component A" /protein_id="NP_388841.1" /db_xref="EnsemblGenomes-Gn:BSU09600" /db_xref="EnsemblGenomes-Tr:CAB12799" /db_xref="GOA:O07590" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13027" /db_xref="UniProtKB/Swiss-Prot:O07590" /translation="MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILG ALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLT LCGSLFAFWCGWTITI*" /label="crcBA CDS" gene complement(937522..937878) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /label="crcBA gene" CDS complement(937875..938270) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /function="16.1: Circulate" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 22194412, 27824896; Product type t : transporter" /codon_start=1 /transl_table=11 /product="subunit of fluoride efflux transporter" /protein_id="NP_388842.1" /db_xref="EnsemblGenomes-Gn:BSU09610" /db_xref="EnsemblGenomes-Tr:CAB12800" /db_xref="GOA:O07591" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13028" /db_xref="UniProtKB/Swiss-Prot:O07591" /translation="MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLL LGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASL ISGIIFALIGVFVGRRIAGIQQRKGLQEK*" /label="crcBB CDS" gene complement(937875..938270) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /label="crcBB gene" CDS complement(938257..938988) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /EC_number="3.1.4.46" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8012593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycerophosphodiester phosphodiesterase" /protein_id="NP_388843.1" /db_xref="EnsemblGenomes-Gn:BSU09620" /db_xref="EnsemblGenomes-Tr:CAB12801" /db_xref="GOA:O07592" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG13029" /db_xref="UniProtKB/Swiss-Prot:O07592" /translation="MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQI VVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKI GLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVIT RPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKL QAMGVDGIVTDYPDFIIKDGKHENI*" /label="yhdW CDS" gene complement(938257..938988) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /label="yhdW gene" misc_feature complement(939013..939032) /Source="Nicolas_upshift_promotors" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(939034) /Source="Nicolas_upshifts" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 939081..939089 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 939098 /Source="Nicolas_upshifts" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 939103..939118 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 939112..939185 /Source="Nicolas_S_feature" /locus_tag="new_1038543_1038616" /HighExp="S5, S4, S6, S7, S8, S3, B60, Pyr, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.563" /TUlongSig="NA" /TUlongPSig="NA" /label="S334" promotor_-35 939172..939173 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 939187 /Source="Nicolas_upshifts" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 939189..939208 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-10" CDS 939222..939329 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388844.1" /db_xref="EnsemblGenomes-Gn:BSU09630" /db_xref="EnsemblGenomes-Tr:CAB12802" /db_xref="InterPro:IPR035384" /db_xref="SubtiList:BG13030" /db_xref="UniProtKB/Swiss-Prot:O07593" /translation="MGKGRIRVEERIKAETDAEMQKATLLDQTQTKKGK*" /label="yhdX CDS" gene 939222..939329 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /label="yhdX gene" S_feature 939330..939383 /Source="Nicolas_S_feature" /locus_tag="new_1038761_1038814" /HighExp="Sw, BC, LPhT, HiOs, S4, HiTm, S5, B36, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S335" downshifts 939354 /Source="Nicolas_upshifts" /id="D507" /incds=0 /nref=177 /ntot=225 /MaxReadThrough="0.97838" /MaxDrop="7.47175" /score="21.9742676" /energy="-14.5" /TU="NA" /idTUdmin="U762" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 939434..939453 /Source="Nicolas_upshift_promotors" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 939440 /Source="Nicolas_upshifts" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 939478..940593 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /function="16.8: Protect" /function="16.12: Sense" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12077558, 15849754, 16850406, 17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12077558, 15849754, 16850406, 17665170, 18310427, 19252899; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small conductance mechano-sensitive channel" /protein_id="NP_388845.1" /db_xref="EnsemblGenomes-Gn:BSU09640" /db_xref="EnsemblGenomes-Tr:CAB12803" /db_xref="GOA:O07594" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR006686" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13031" /db_xref="UniProtKB/Swiss-Prot:O07594" /translation="MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFN LTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVAL LCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYD VNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITF RSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSL RTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEIL GAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA*" /label="mscY CDS" gene 939478..940593 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /label="mscY gene" downshifts 940573 /Source="Nicolas_upshifts" /id="D508" /incds=0 /nref=5 /ntot=141 /MaxReadThrough="3.45709" /MaxDrop="3.93891" /score="2.31392404" /energy="-12.3" /TU="U764" /idTUdmin="U764" /TUdmin="-783" /isTUend="FALSE" /label="downshifts" misc_feature 940630..940649 /Source="Nicolas_upshift_promotors" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 940630 /Source="Nicolas_upshifts" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 940663..941406 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16768447, 19136592, 26708127, 27987242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16768447, 19136592, 26708127, 27987242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirtuin NAD-dependent deacetylase" /protein_id="NP_388846.1" /db_xref="EnsemblGenomes-Gn:BSU09650" /db_xref="EnsemblGenomes-Tr:CAB12804" /db_xref="GOA:O07595" /db_xref="InterPro:IPR003000" /db_xref="InterPro:IPR026590" /db_xref="InterPro:IPR028628" /db_xref="InterPro:IPR029035" /db_xref="SubtiList:BG13032" /db_xref="UniProtKB/Swiss-Prot:O07595" /translation="METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASR MEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNI DGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIIN LEPTYCDSLFDMVIHQKIGEFARSLGMKK*" /label="srtN CDS" gene 940663..941406 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /label="srtN gene" downshifts 941378 /Source="Nicolas_upshifts" /id="D509" /incds=0 /nref=3 /ntot=82 /MaxReadThrough="1.93149" /MaxDrop="2.85561" /score="9.76884826" /energy="-9.2" /TU="NA" /idTUdmin="U765" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(941430..942278) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide deacetylase" /protein_id="NP_388847.1" /db_xref="EnsemblGenomes-Gn:BSU09660" /db_xref="EnsemblGenomes-Tr:CAB12805" /db_xref="GOA:O07596" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG13046" /db_xref="UniProtKB/Swiss-Prot:O07596" /translation="MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKA KEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRL LDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLK EMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYR NSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDT MVPVHE*" /label="yheN CDS" gene complement(941430..942278) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /label="yheN gene" downshifts complement(941454) /Source="Nicolas_upshifts" /id="D510" /incds=0 /nref=126 /ntot=242 /MaxReadThrough="2.03966" /MaxDrop="4.72968" /score="-7.82934513" /energy="-9.2" /TU="NA" /idTUdmin="U767" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 942274..942279 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(942279..942378) /Source="Nicolas_S_feature" /locus_tag="new_1041710_1041809_c" /HighExp="Cold, T3.0H, T2.30H, T3.30H, T4.0H, T2.0H, HPh, C30, T1.30H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S336" promotor_-10 942295..942313 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 942297 /Source="Nicolas_upshifts" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="upshifts" S_feature 942302..942497 /Source="Nicolas_S_feature" /locus_tag="new_1041733_1041928" /HighExp="S5, S4, S6, S3, S7, S8, LoTm, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S337" promotor_-10 complement(942367..942386) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(942381) /Source="Nicolas_upshifts" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(942401..942404) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 942496..942515 /Source="Nicolas_upshift_promotors" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 942499..942562 /Source="Nicolas_S_feature" /locus_tag="new_1041930_1041993" /HighExp="BC, T2.30H, T3.0H, T3.30H, T4.0H, T5.0H, T2.0H, T1.30H, S4, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S338" upshifts 942499 /Source="Nicolas_upshifts" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="upshifts" CDS 942563..943411 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /EC_number="2.6.1.21" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9003455, 17005988; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine aminotransferase" /protein_id="NP_388848.1" /db_xref="EnsemblGenomes-Gn:BSU09670" /db_xref="EnsemblGenomes-Tr:CAB12806" /db_xref="GOA:O07597" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005784" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG13045" /db_xref="UniProtKB/Swiss-Prot:O07597" /translation="MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGL REHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQY EAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYE AGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIK LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQ QAASIS*" /label="dat CDS" gene 942563..943411 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /label="dat gene" downshifts 943402 /Source="Nicolas_upshifts" /id="D511" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="2.27201" /MaxDrop="6.88888" /score="21.6239924" /energy="-11.5" /TU="U768" /idTUdmin="U766" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(943454..944815) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735849, 11274110, 15849754, 16850406, 17937670" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 11274110, 15849754, 16850406, 17937670; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_388849.1" /db_xref="EnsemblGenomes-Gn:BSU09680" /db_xref="EnsemblGenomes-Tr:CAB12807" /db_xref="GOA:O07553" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG13044" /db_xref="UniProtKB/Swiss-Prot:O07553" /translation="MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVM LSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALS FIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAA STDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFV PYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIG LISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQ RKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGF VKK*" /label="nhaC CDS" gene complement(943454..944815) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /label="nhaC gene" downshifts complement(943478) /Source="Nicolas_upshifts" /id="D512" /incds=0 /nref=7 /ntot=77 /MaxReadThrough="0.50034" /MaxDrop="3.60175" /score="1.04025421" /energy="-11.5" /TU="NA" /idTUdmin="U769" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(944816..944886) /Source="Nicolas_S_feature" /locus_tag="new_1044247_1044317_c" /HighExp="B60, G135, Etha, LBGexp, G150, Diami, Paraq, G180, H2O2, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S339" misc_feature complement(944859..944878) /Source="Nicolas_upshift_promotors" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(944886) /Source="Nicolas_upshifts" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(944942..945442) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /function="16.12: Sense" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 16159758, 27464829; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein, UspA family" /protein_id="NP_388850.2" /db_xref="EnsemblGenomes-Gn:BSU09690" /db_xref="EnsemblGenomes-Tr:CAB12808" /db_xref="GOA:O07552" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13043" /db_xref="UniProtKB/Swiss-Prot:O07552" /translation="MFHADRIIVAFDGSENSKKALLTAIDLAKTVNAAITVAHSHDMK DNQTVIDPPRPAAEASYISGGMTSVPDPLISDVTSPEPMIYEDRTEEVIAEARMMLNE QQADGDIDILEGDPAESIIEHANRISADMIVTGSRDQNRLKKLIFGSVSEKLSAKSDI PVLIVK*" /label="nhaX CDS" gene complement(944942..945442) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /label="nhaX gene" downshifts complement(944974) /Source="Nicolas_upshifts" /id="D513" /incds=0 /nref=10 /ntot=63 /MaxReadThrough="4.74071" /MaxDrop="5.69273" /score="4.44189378" /energy="-12.2" /TU="U770" /idTUdmin="U770" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(945464..945482) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(945484) /Source="Nicolas_upshifts" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(945497..945503) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 945521..945528 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 945536..945605 /Source="Nicolas_S_feature" /locus_tag="new_1044967_1045036" /HighExp="C90, M9-stat, BC, T1.30H, T3.30H, Sw, T5.0H, GM 15, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S340" upshifts 945537 /Source="Nicolas_upshifts" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 945543..945562 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 945606..945767 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /experiment="publication(s) with functional evidences, PMID:25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25217586; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator leader peptide" /protein_id="NP_388851.1" /db_xref="EnsemblGenomes-Gn:BSU09700" /db_xref="EnsemblGenomes-Tr:CAB12809" /db_xref="SubtiList:BG13042" /db_xref="UniProtKB/Swiss-Prot:O07551" /translation="MFIKQFHIGAANLLFCFRERFFRSDRALKSAVRNISVKKGMELT LHAFFIYKI*" /label="bmrB CDS" gene 945606..945767 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /label="bmrB gene" downshifts 945697 /Source="Nicolas_upshifts" /id="D514" /incds=1 /nref=29 /ntot=180 /MaxReadThrough="5.31538" /MaxDrop="4.59672" /score="25.6910195" /energy="-14.4" /TU="U771" /idTUdmin="U768" /TUdmin=2273 /isTUend="FALSE" /label="downshifts" S_feature 945768..945886 /Source="Nicolas_S_feature" /locus_tag="new_1045199_1045317" /HighExp="LPhT, S7, S6, T-1.10H, Sw, LBGstat, S5, T-0.40H, S8, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S341" CDS 945887..947644 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388852.1" /db_xref="EnsemblGenomes-Gn:BSU09710" /db_xref="EnsemblGenomes-Tr:CAB12810" /db_xref="GOA:O07550" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13041" /db_xref="UniProtKB/Swiss-Prot:O07550" /translation="MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAI DDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWK LTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQET NDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLG ELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEP GDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGE GSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAE AHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAK TEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWY REQYERQQLFTAEEGGAGA*" /label="bmrC CDS" gene 945887..947644 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /label="bmrC gene" CDS 947641..949662 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding subunit)" /protein_id="NP_388853.1" /db_xref="EnsemblGenomes-Gn:BSU09720" /db_xref="EnsemblGenomes-Tr:CAB12811" /db_xref="GOA:O07549" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13040" /db_xref="UniProtKB/Swiss-Prot:O07549" /translation="MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMID DHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQ AVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLL VFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTE AIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASY YNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNS LMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQ FSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGI VLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGST LSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHR LSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA*" /label="bmrD CDS" gene 947641..949662 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /label="bmrD gene" downshifts 949650 /Source="Nicolas_upshifts" /id="D515" /incds=0 /nref=69 /ntot=230 /MaxReadThrough="0.741399999999999" /MaxDrop="5.11492" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U771" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(949711..950331) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-flavin oxidoreductase" /protein_id="NP_388854.1" /db_xref="EnsemblGenomes-Gn:BSU09730" /db_xref="EnsemblGenomes-Tr:CAB12812" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13039" /db_xref="UniProtKB/Swiss-Prot:O07548" /translation="MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKD RTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIG TAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGT ATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY*" /label="yheG CDS" gene complement(949711..950331) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /label="yheG gene" downshifts complement(949726) /Source="Nicolas_upshifts" /id="D516" /incds=0 /nref=19 /ntot=169 /MaxReadThrough="1.82652" /MaxDrop="3.00293" /score="-0.293143554" /energy="-10.9" /TU="NA" /idTUdmin="U772" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 950316..950416 /Source="Nicolas_upshift_promotors" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(950345..950364) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(950360) /Source="Nicolas_upshifts" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="upshifts" CDS complement(950370..950495) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388855.1" /db_xref="EnsemblGenomes-Gn:BSU09740" /db_xref="EnsemblGenomes-Tr:CAB12813" /db_xref="SubtiList:BG13038" /db_xref="UniProtKB/Swiss-Prot:O07547" /translation="MSFITIVNWELVQFVSVSMIHEYVSHRSVYLYRYSFPRCSN*" /label="yheF CDS" gene complement(950370..950495) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /label="yheF gene" upshifts 950376 /Source="Nicolas_upshifts" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(950379..950382) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(950509..950528) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(950518) /Source="Nicolas_upshifts" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(950542..950551) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 950574 /Source="Nicolas_upshifts" /id="D517" /incds=0 /nref=6 /ntot=22 /MaxReadThrough="0.352760000000001" /MaxDrop="4.67633" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U773" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(950600..950803) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:3009398, 9572981, 16707666, 19659696, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009398, 9572981, 16707666, 19659696, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (beta-type SASP)" /protein_id="NP_388856.1" /db_xref="EnsemblGenomes-Gn:BSU09750" /db_xref="EnsemblGenomes-Tr:CAB12814" /db_xref="GOA:P04832" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10787" /db_xref="UniProtKB/Swiss-Prot:P04832" /translation="MANQNSSNDLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRANG SVGGEITKRLVSFAQQQMGGRVQ*" /label="sspB CDS" gene complement(950600..950803) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /label="sspB gene" downshifts complement(950605) /Source="Nicolas_upshifts" /id="D518" /incds=0 /nref=72 /ntot=93 /MaxReadThrough="1.27819" /MaxDrop="8.55895" /score="22.2113888" /energy="-16" /TU="NA" /idTUdmin="U776" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(950804..950914) /Source="Nicolas_S_feature" /locus_tag="new_1050235_1050345_c" /HighExp="S8, S5, S7, S6, S4, G/S, Pyr, ferm, BT, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S342" promotor_no_box 950844..950944 /Source="Nicolas_upshift_promotors" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 950904 /Source="Nicolas_upshifts" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(950920) /Source="Nicolas_upshifts" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(950924..950935) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(950950..950956) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(951012..951230) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation / germination island)" /protein_id="NP_388857.1" /db_xref="EnsemblGenomes-Gn:BSU09760" /db_xref="EnsemblGenomes-Tr:CAB12815" /db_xref="InterPro:IPR017263" /db_xref="SubtiList:BG13037" /db_xref="UniProtKB/Swiss-Prot:O07546" /translation="MAVMISHFSWKPLFPKEKLPGWKISFYYKGTHYEGIYHKSGEIE WGDLFPARADEPALTNEIHELMLFHIYD*" /label="yheE CDS" gene complement(951012..951230) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /label="yheE gene" downshifts complement(951046) /Source="Nicolas_upshifts" /id="D519" /incds=0 /nref=5 /ntot=83 /MaxReadThrough="0.43384" /MaxDrop="3.42951" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U777" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(951271..951290) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(951288) /Source="Nicolas_upshifts" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(951304..951311) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(951380..952741) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /function="16.5: Explore" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15231775, 25035995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 25035995; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat associated protein" /protein_id="NP_388858.2" /db_xref="EnsemblGenomes-Gn:BSU09770" /db_xref="EnsemblGenomes-Tr:CAB12816" /db_xref="GOA:O07545" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13036" /db_xref="UniProtKB/Swiss-Prot:O07545" /translation="MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVA YRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFK DRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYD RLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSEL TPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSD AASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISG KNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGF DFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEAL WPS*" /label="spaD CDS" gene complement(951380..952741) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /label="spaD gene" downshifts complement(951398) /Source="Nicolas_upshifts" /id="D520" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.33323" /MaxDrop="3.7968" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(951442) /Source="Nicolas_upshifts" /id="D521" /incds=1 /nref=2 /ntot=45 /MaxReadThrough="5.29177" /MaxDrop="3.36501" /score="37.4339943" /energy="-11.8" /TU="U779" /idTUdmin="U779" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(952731..953822) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231775, 25035995; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat associated protein, subunit C" /protein_id="NP_388859.1" /db_xref="EnsemblGenomes-Gn:BSU09780" /db_xref="EnsemblGenomes-Tr:CAB12817" /db_xref="GOA:O07544" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13035" /db_xref="UniProtKB/Swiss-Prot:O07544" /translation="MITLGFMSLSRQHEADYSAELAKRAPEFGIRFIRFTPFDISPDT LRVKASVYHSASSTWNETEMAIPDYIYDRCFYGKDSHSQKAKPIVEWLKKYPKTEFIG RGLPDKWTVLHDLQQHSVINPYIPETIKVSRYEQIHSFLSKEKACILKPAFGAGGRGV ILLKLGKKNITATYHIGKDKQTKTFSNQTSFKTWCKKVLQHQYLLQPYLNIQDKEQYP CDIRLFMEKNEAGEWNTVGKAVRRGYKHGLLANLSGGSDALTFDSWFEDIPKKQQVVL LDDVFSITQSVPYYLDERYGPLFELGLDICLAKDGRIWILDINSKPGRKSILRVSPEQ KEQLYTCPLKRCQYLFSEQSQKGVLPRES*" /label="spaC CDS" gene complement(952731..953822) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /label="spaC gene" promotor_-10 complement(953146..953160) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(953158) /Source="Nicolas_upshifts" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(953174..953182) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(953823..953928) /Source="Nicolas_S_feature" /locus_tag="new_1053254_1053359_c" /HighExp="S4, B36, S5, S6, S7, S8, B60, S3, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S343" promotor_-10 complement(953912..953930) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(953932) /Source="Nicolas_upshifts" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(953946..953951) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 953994..954001 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 954016..954035 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 954027 /Source="Nicolas_upshifts" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="upshifts" CDS 954089..955222 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16684363" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388860.1" /db_xref="EnsemblGenomes-Gn:BSU09790" /db_xref="EnsemblGenomes-Tr:CAB12818" /db_xref="GOA:O07543" /db_xref="InterPro:IPR007383" /db_xref="InterPro:IPR016991" /db_xref="SubtiList:BG13034" /db_xref="UniProtKB/Swiss-Prot:O07543" /translation="MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVP FTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLS EVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEE KIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVL PELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFST APFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQ FPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF*" /label="yheB CDS" gene 954089..955222 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /label="yheB gene" S_feature 955223..955314 /Source="Nicolas_S_feature" /locus_tag="new_1054654_1054745" /HighExp="S4, S5, S6, BT, S3, S7, dia15, B36, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S344" CDS 955315..955668 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388861.1" /db_xref="EnsemblGenomes-Gn:BSU09800" /db_xref="EnsemblGenomes-Tr:CAB12819" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="PDB:2OEE" /db_xref="SubtiList:BG13033" /db_xref="UniProtKB/Swiss-Prot:O07542" /translation="MAVNFYDVAYDLENALRGSEEFTRLKNLYDEVNADESAKRMFEN FRDVQLRLQQKQMAGEEITQEEVTQAQKTVALVQQHEKISQLMEAEQRMSMLIGELNK IIMKPLEELYGSVEG*" /label="yheA CDS" gene 955315..955668 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /label="yheA gene" downshifts 955656 /Source="Nicolas_upshifts" /id="D522" /incds=0 /nref=159 /ntot=259 /MaxReadThrough="1.55668" /MaxDrop="5.9901" /score="24.5275597" /energy="-12.3" /TU="NA" /idTUdmin="U780" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(955712..956785) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290, 22933559" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388862.1" /db_xref="EnsemblGenomes-Gn:BSU09810" /db_xref="EnsemblGenomes-Tr:CAB12820" /db_xref="GOA:O07541" /db_xref="InterPro:IPR011989" /db_xref="InterPro:IPR014825" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR021133" /db_xref="SubtiList:BG13002" /db_xref="UniProtKB/Swiss-Prot:O07541" /translation="MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPEL TLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEES IKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWG KSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTH PHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYI HSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHY KGIHTLSVIINGEVKDSLDFQVC*" /label="yhaZ CDS" gene complement(955712..956785) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /label="yhaZ gene" downshifts complement(955819) /Source="Nicolas_upshifts" /id="D523" /incds=1 /nref=16 /ntot=173 /MaxReadThrough="3.78071" /MaxDrop="3.586" /score="4.43596345" /energy="-12.3" /TU="U781" /idTUdmin="U781" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(956807..956826) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(956819) /Source="Nicolas_upshifts" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(956840..956847) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 956922..956929 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 956942 /Source="Nicolas_upshifts" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 956944..956963 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 956953..957106 /Source="Nicolas_S_feature" /locus_tag="new_1056384_1056537" /HighExp="M9-stat, BC, T0.30H, T1.30H, Lbstat, T1.0H, T3.30H, T2.0H, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S345" downshifts 957063 /Source="Nicolas_upshifts" /id="D524" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="7.40404" /MaxDrop="2.6506" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 957108..957191 /Source="Nicolas_S_feature" /locus_tag="new_1056539_1056622" /HighExp="M9-stat, B60, T2.0H, T1.30H, T0.30H, T2.30H, T3.0H, T1.0H, Lbtran, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S346" downshifts 957148 /Source="Nicolas_upshifts" /id="D525" /incds=0 /nref=70 /ntot=231 /MaxReadThrough="4.88371" /MaxDrop="4.4099" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-971" /isTUend="FALSE" /label="downshifts" promotor_-35 957204..957209 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 957225..957243 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 957234 /Source="Nicolas_upshifts" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 957271..958137 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388864.2" /db_xref="EnsemblGenomes-Gn:BSU09830" /db_xref="EnsemblGenomes-Tr:CAB12822" /db_xref="GOA:O07539" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR036412" /db_xref="PDB:3DNP" /db_xref="SubtiList:BG13000" /db_xref="UniProtKB/Swiss-Prot:O07539" /translation="MSKQLLALNIDGALLRSNGKIHQATKDAIEYVKKKGIYVTLVTN RHFRSAQKIAKSLKLDAKLITHSGAYIAEKIDAPFFEKRISDDHTFNIVQVLESYQCN IRLLHEKYSIGNKKKVNSNLLGKALIHPSDPIFYPVQFVESLSDLLMDEPVSAPVIEV YTEHDIQHDITETITKAFPAVDVIRVNDEKLNIVPKGVSKEAGLALVASELGLSMDDV VAIGHQYDDLPMIELAGLGVAMGNAVPEIKRKADWVTRSNDEQGVAYMMKEYFRMQQR KGFLDKFHMKRV*" /label="yhaX CDS" gene 957271..958137 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /label="yhaX gene" downshifts 958119 /Source="Nicolas_upshifts" /id="D526" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="3.99904" /MaxDrop="4.7771" /score="15.7706912" /energy="-16.6" /TU="U783" /idTUdmin="U782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 958182..958185 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 958200..958219 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 958208 /Source="Nicolas_upshifts" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 958249..959754 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /EC_number="1.3.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10498703, 21255303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498703, 21255303; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_388865.1" /db_xref="EnsemblGenomes-Gn:BSU09840" /db_xref="EnsemblGenomes-Tr:CAB12823" /db_xref="GOA:Q796V8" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023995" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG12999" /db_xref="UniProtKB/Swiss-Prot:Q796V8" /translation="MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISL ALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTG ITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEW LKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITE EKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLI IGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMM EDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCG AASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH*" /label="hemZ CDS" gene 958249..959754 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /label="hemZ gene" downshifts 959724 /Source="Nicolas_upshifts" /id="D527" /incds=0 /nref=113 /ntot=234 /MaxReadThrough="0.523269999999999" /MaxDrop="5.05369" /score="38.1573779" /energy="-14.4" /TU="NA" /idTUdmin="U783" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(959772..960989) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7934942, 14987767, 15849754, 15919996, 16850406, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934942, 14987767, 15849754, 15919996, 16850406, 24330391; Product type t : transporter" /codon_start=1 /transl_table=11 /product="proton/potassium antiporter; methylglyoxal resistance" /protein_id="NP_388866.2" /db_xref="EnsemblGenomes-Gn:BSU09850" /db_xref="EnsemblGenomes-Tr:CAB12825" /db_xref="GOA:O07536" /db_xref="InterPro:IPR006153" /db_xref="SubtiList:BG12997" /db_xref="UniProtKB/Swiss-Prot:O07536" /translation="MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHA PKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILI NFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIR SNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFF GAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGL TIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVF KWKPEVQPAKKQG*" /label="khtU CDS" gene complement(959772..960989) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /label="khtU gene" downshifts complement(959778) /Source="Nicolas_upshifts" /id="D528" /incds=0 /nref=154 /ntot=249 /MaxReadThrough="1.74386" /MaxDrop="6.8685" /score="8.64654688" /energy="-14.4" /TU="NA" /idTUdmin="U785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(960996..961493) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388867.1" /db_xref="EnsemblGenomes-Gn:BSU09860" /db_xref="EnsemblGenomes-Tr:CAB12826" /db_xref="GOA:O07535" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG12996" /db_xref="UniProtKB/Swiss-Prot:O07535" /translation="MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRD PDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGR TLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFL SGEGV*" /label="khtT CDS" gene complement(960996..961493) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /label="khtT gene" CDS complement(961557..961895) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388868.1" /db_xref="EnsemblGenomes-Gn:BSU09870" /db_xref="EnsemblGenomes-Tr:CAB12827" /db_xref="GOA:O07534" /db_xref="SubtiList:BG12995" /db_xref="UniProtKB/Swiss-Prot:O07534" /translation="MRREERNMDKLLISFLLSLFMVYFPPSDVVLPSQFEASTDSYVP MSSYPQETQSAKTPSPGSMHPAELIKEYSPLAQSVRQLSVKPLDEPLINRLEKALAVP VKYQSNYLRI*" /label="khtS CDS" gene complement(961557..961895) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /label="khtS gene" promotor_-10 complement(961907..961926) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(961931) /Source="Nicolas_upshifts" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(961940..961947) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 961967..961974 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 961989..962008 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 961999 /Source="Nicolas_upshifts" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="upshifts" CDS 962060..962827 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22961985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase / isomerase" /protein_id="NP_388869.3" /db_xref="EnsemblGenomes-Gn:BSU09880" /db_xref="EnsemblGenomes-Tr:CAB12828" /db_xref="GOA:O07533" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12994" /db_xref="UniProtKB/Swiss-Prot:O07533" /translation="MEFVQYACNGAVAEIILNRPDAHHALNEQMLSELKEAVEMAAAS EALIVLLRGSGKGFSAGGDIRMMTSEHDPDQFKRLMDTIEAVTLNLYQMKKVTIAAIH GAAAGLGLSLALCADIVLAEKNAVLAMNFIGIGLVPDGGGHYLLKKRIGEAKAKKLIW SGKKLSASEAADMGLLDGTFAGDPAEGARPIIETLLASPLLAMIETKGIFQSLQIEEL KKVLSLERSAQERMRRTKDHQEGIRAFLEKREPKFQA*" /label="yhaR CDS" gene 962060..962827 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /label="yhaR gene" downshifts 962828 /Source="Nicolas_upshifts" /id="D529" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="1.78111" /MaxDrop="4.66019" /score="-8.79921781" /energy="-7.5" /TU="NA" /idTUdmin="U786" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(962848..963033) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097698.1" /db_xref="EnsemblGenomes-Gn:BSU09889" /db_xref="EnsemblGenomes-Tr:CAX52586" /db_xref="InterPro:IPR025544" /db_xref="UniProtKB/Swiss-Prot:C0H3Y1" /translation="MADYFLTVFDPSGNTLVNEQFEAEHEEAAKTHGEALLKEKELHS HTHRLVNAAGKLILFHR*" /label="yhzD CDS" gene complement(962848..963033) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /label="yhzD gene" promotor_-10 complement(963069..963087) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(963080) /Source="Nicolas_upshifts" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(963098..963106) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 963107..963110 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 963125..963144 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 963135 /Source="Nicolas_upshifts" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="upshifts" CDS 963160..964056 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 12374817; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388870.2" /db_xref="EnsemblGenomes-Gn:BSU09890" /db_xref="EnsemblGenomes-Tr:CAB12829" /db_xref="GOA:C0SPB4" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12993" /db_xref="UniProtKB/Swiss-Prot:C0SPB4" /translation="MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTF RMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGME KREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGL DPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKR SFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIR KFELEEPSLHDIFIEKVGAVYE*" /label="yhaQ CDS" gene 963160..964056 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /label="yhaQ gene" CDS 964049..965308 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent exporter (ABC permease)" /protein_id="NP_388871.2" /db_xref="EnsemblGenomes-Gn:BSU09900" /db_xref="EnsemblGenomes-Tr:CAB12830" /db_xref="GOA:O07523" /db_xref="SubtiList:BG12992" /db_xref="UniProtKB/Swiss-Prot:O07523" /translation="MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISL FQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLD GMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLY APVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVM EILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLT DVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMF GLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGAR IYKGGVLIYGNSSAFKAIKQALRLAKN*" /label="yhaP CDS" gene 964049..965308 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /label="yhaP gene" downshifts 965292 /Source="Nicolas_upshifts" /id="D530" /incds=0 /nref=19 /ntot=187 /MaxReadThrough="2.50232" /MaxDrop="3.26822" /score="8.93460501" /energy="-12.8" /TU="NA" /idTUdmin="U788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 965356..965363 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 965375..965394 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 965380 /Source="Nicolas_upshifts" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 965415..966641 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA repair exonuclease" /protein_id="NP_388872.1" /db_xref="EnsemblGenomes-Gn:BSU09910" /db_xref="EnsemblGenomes-Tr:CAB12831" /db_xref="GOA:O07522" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR014576" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12991" /db_xref="UniProtKB/Swiss-Prot:O07522" /translation="MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHM IDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGG EWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDA PFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPG NTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVE DTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRL DDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIK EQAQIILKRQLKVLDT*" /label="yhaO CDS" gene 965415..966641 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /label="yhaO gene" downshifts complement(966116) /Source="Nicolas_upshifts" /id="D531" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="0.0165100000000002" /MaxDrop="3.62411" /score="-5.83060322" /energy="-15.2" /TU="NA" /idTUdmin="U787" /TUdmin="-3300" /isTUend="FALSE" /label="downshifts" CDS 966646..969537 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16267290, 19906728, 21517913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267290, 19906728, 21517913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA double strand break repair and recombination" /protein_id="NP_388873.1" /db_xref="EnsemblGenomes-Gn:BSU09920" /db_xref="EnsemblGenomes-Tr:CAB12832" /db_xref="GOA:O08455" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12990" /db_xref="UniProtKB/Swiss-Prot:O08455" /translation="MTALRIISLHIYQYGKFSNRTFDFSASPVQVIYGLNEAGKTTMM SFIESMLFGFPKTKKYEPKTGGVYGGVLEAEHPEYGVLKIERTKGTAEKLSVYTEKGE VKQGDVLKQLFQGTDRSLYKAIYSFDVFGLQEIHAFNRDKIGEFLLFSSLFGAEAVSK LDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAGYHQLLEEKRTLEA RLAAAETELKETAGHIRMIEGAIERKPLLNEKATLEQVIAEFPEHAGQFPADGLHQLE KYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGE QLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNTSYDYEWQLQQAVQQYVQARDRK RQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDETQGQHQEQAKLR EQLTFFERQQAKQKKTVIAAGMLFIVLFSLLQQWIPAISFGAALIVYWLVSGKSSSRN SRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWE AEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRR TFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLEL EQEIQYFHAQIEQLFAAAAAKDRDAFFAIAAISRQLKDTENKLHHVNAQLQGGYPEEL ELADSNTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQ TEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRLLETAGEFFRPLTDGNYQT IYFSETDDSIMVMHRDGTVYHAEELSQGTCEQLYTAIRFALAVTRQGESKLPFQLDDS FVHFDQERLKRVLHVLYDLSEGGRQILYFTCHEHVKDAFHSSQIIHLVS*" /label="sbcE CDS" gene 966646..969537 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /label="sbcE gene" promotor_-35 967927..967932 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 967948..967966 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 967954 /Source="Nicolas_upshifts" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 969545..969550 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 969565..969584 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 969580 /Source="Nicolas_upshifts" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 969611..970555 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 16267290, 19553197, 19880604" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 16267290, 19553197, 19880604; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3'-5' exonuclease" /protein_id="NP_388874.1" /db_xref="EnsemblGenomes-Gn:BSU09930" /db_xref="EnsemblGenomes-Tr:CAB12833" /db_xref="GOA:O07521" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020873" /db_xref="SubtiList:BG12989" /db_xref="UniProtKB/Swiss-Prot:O07521" /translation="MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSG DIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFL ETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGL AYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGH ISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNL DAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK*" /label="yhaM CDS" gene 969611..970555 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /label="yhaM gene" downshifts 970533 /Source="Nicolas_upshifts" /id="D532" /incds=0 /nref=183 /ntot=261 /MaxReadThrough="3.02818" /MaxDrop="5.88173" /score="6.06919899" /energy="-15.8" /TU="NA" /idTUdmin="U789" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 970614..970619 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 970635..970653 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 970638 /Source="Nicolas_upshifts" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="upshifts" CDS 970680..970892 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523133; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="sporulation factor" /protein_id="NP_388875.1" /db_xref="EnsemblGenomes-Gn:BSU09940" /db_xref="EnsemblGenomes-Tr:CAB12834" /db_xref="GOA:O07520" /db_xref="InterPro:IPR025428" /db_xref="SubtiList:BG12988" /db_xref="UniProtKB/Swiss-Prot:O07520" /translation="MLFFPWWVYLCIVGIIFSAYKLVAAAKEEEKVDQAFIEKEGQIY MERMEKERERRSSQQHEEENQNHSIA*" /label="yhaL CDS" gene 970680..970892 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /label="yhaL gene" downshifts 970885 /Source="Nicolas_upshifts" /id="D533" /incds=0 /nref=8 /ntot=158 /MaxReadThrough="2.03283" /MaxDrop="6.60832" /score="62.1892984" /energy="-22" /TU="NA" /idTUdmin="U792" /TUdmin=5 /isTUend="TRUE" /label="downshifts" downshifts complement(970923) /Source="Nicolas_upshifts" /id="D534" /incds=0 /nref=97 /ntot=260 /MaxReadThrough="0.90997" /MaxDrop="9.00938" /score="52.3375501" /energy="-22" /TU="NA" /idTUdmin="U793" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(970933..971811) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12634326, 12682299, 14976191, 16516208, 25525259, 26711778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12634326, 12682299, 14976191, 16516208, 25525259, 26711778; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molecular chaperone lipoprotein" /protein_id="NP_388876.1" /db_xref="EnsemblGenomes-Gn:BSU09950" /db_xref="EnsemblGenomes-Tr:CAB12835" /db_xref="GOA:P24327" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR023059" /db_xref="InterPro:IPR027304" /db_xref="PDB:1ZK6" /db_xref="PDB:4WO7" /db_xref="SubtiList:BG10464" /db_xref="UniProtKB/Swiss-Prot:P24327" /translation="MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTN MKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLK EQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKG EKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYH IIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFN TSSTSNSTSSSSSNSK*" /label="prsA CDS" gene complement(970933..971811) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /label="prsA gene" downshifts complement(971121) /Source="Nicolas_upshifts" /id="D535" /incds=1 /nref=10 /ntot=127 /MaxReadThrough="7.54458" /MaxDrop="3.5906" /score="52.3375501" /energy="-22" /TU="U793" /idTUdmin="U793" /TUdmin="-187" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(971849..971868) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(971873) /Source="Nicolas_upshifts" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(971882..971889) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 971909..971918 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 971930 /Source="Nicolas_upshifts" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 971931..971950 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(971967..971981) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(971968) /Source="Nicolas_upshifts" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 971971..972057 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:20156992, 21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20156992, 21670523; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="spore assembly and germination protein" /protein_id="YP_003097699.1" /db_xref="EnsemblGenomes-Gn:BSU09958" /db_xref="EnsemblGenomes-Tr:CAX52587" /db_xref="GOA:C0H3Y2" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y2" /translation="MSGGYSNGFALLVVLFILLIIVGAAYIY*" /label="sscA CDS" gene 971971..972057 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /label="sscA gene" promotor_-35 complement(971990..971994) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 972058..972309 /Source="Nicolas_S_feature" /locus_tag="new_1071489_1071740" /HighExp="S8, S7, S6, BT, G/S, B36, Pyr, S5, B60, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S347" CDS 972182..972268 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore and germination protein" /protein_id="YP_009513948.1" /db_xref="EnsemblGenomes-Gn:BSU09959" /db_xref="EnsemblGenomes-Tr:CCQ48595" /db_xref="GOA:L8EBJ6" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8EBJ6" /translation="MGEVFAGGFALLVVLFILLIIIGASWLY*" /label="sscB CDS" gene 972182..972268 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /label="sscB gene" downshifts 972266 /Source="Nicolas_upshifts" /id="D536" /incds=0 /nref=28 /ntot=50 /MaxReadThrough="4.67734" /MaxDrop="4.7906" /score="14.3797211" /energy="-17.6" /TU="U794" /idTUdmin="U794" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" S_feature complement(972278..972540) /Source="Nicolas_S_feature" /locus_tag="new_1071709_1071971_c" /HighExp="LBGtran, LBGstat, LPhT, LBGexp, HPh, dia15, T0.30H, dia0, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S348" S_feature 972311..972794 /Source="Nicolas_S_feature" /locus_tag="new_1071742_1072225" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, Glucon, G/S, C90" /AntisenseName="yhaJ" /AntisenseCor="-0.22462434208606599" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S349" downshifts complement(972321) /Source="Nicolas_upshifts" /id="D537" /incds=0 /nref=153 /ntot=265 /MaxReadThrough="1.32339" /MaxDrop="6.55635" /score="34.7913848" /energy="-17.6" /TU="NA" /idTUdmin="U796" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(972533..972552) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(972540) /Source="Nicolas_upshifts" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(972542..972610) /Source="Nicolas_S_feature" /locus_tag="new_1071973_1072041_c" /HighExp="Paraq, G180, C30, LBGexp, Oxctl, G135, Lbexp, Heat, G150, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29568499999999998" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S350" promotor_-35 complement(972566..972571) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(972611..973129) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009, 21670523, 25651892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme" /protein_id="NP_388878.2" /db_xref="EnsemblGenomes-Gn:BSU09965" /db_xref="EnsemblGenomes-Tr:CAB12837" /db_xref="GOA:O07518" /db_xref="InterPro:IPR021683" /db_xref="SubtiList:BG12986" /db_xref="UniProtKB/Swiss-Prot:O07518" /translation="MNCWKTINLMKDYGAVRIILTAVCFMILVFISTFLAFELLRPGT SLSDEYVSLFGGLLVVILFVHKVIHVLPIICKKRKIEKKFYILRMRTWKRIPKTTMLI SLVSPFLLITPVLFYAALAFPNHAHYFCMISGIHAGYCLPDFLLALKLIKAPKTAFID QEADGLDILVEK*" /label="yhaJ CDS" gene complement(972611..973129) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /label="yhaJ gene" promotor_-35 972916..972924 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 972936..972954 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 972949 /Source="Nicolas_upshifts" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(973160..973179) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(973178) /Source="Nicolas_upshifts" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(973195..973201) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 973278..973281 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 973296..973315 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 973301 /Source="Nicolas_upshifts" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="upshifts" CDS 973337..973678 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388879.1" /db_xref="EnsemblGenomes-Gn:BSU09980" /db_xref="EnsemblGenomes-Tr:CAB12838" /db_xref="InterPro:IPR015058" /db_xref="InterPro:IPR035945" /db_xref="PDB:1SED" /db_xref="SubtiList:BG12985" /db_xref="UniProtKB/Swiss-Prot:O07517" /translation="MDSMDHRIERLEYYIQLLVKTVDMDRYPFYALLIDKGLSKEEGE AVMRICDELSEELATQKAQGFVTFDKLLALFAGQLNEKLDVHETIFALYEQGLYQELM EVFIDIMKHFD*" /label="yhaI CDS" gene 973337..973678 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /label="yhaI gene" S_feature complement(973532..973674) /Source="Nicolas_S_feature" /locus_tag="new_1072963_1073105_c" /HighExp="BC, S1, Sw, S2, S3, S8, S5, S4, S6, S7" /AntisenseName="yhaI" /AntisenseCor="5.4889858269512502E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S351" downshifts complement(973575) /Source="Nicolas_upshifts" /id="D538" /incds=1 /nref=39 /ntot=209 /MaxReadThrough="2.89899" /MaxDrop="4.77791" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(973675..974286) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of extracellular protease production, sporulation and bacilysin production (MarR family)" /protein_id="NP_388880.1" /db_xref="EnsemblGenomes-Gn:BSU09990" /db_xref="EnsemblGenomes-Tr:CAB12839" /db_xref="GOA:P11065" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR023488" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FXA" /db_xref="SubtiList:BG10659" /db_xref="UniProtKB/Swiss-Prot:P11065" /translation="MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDL NINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNT YVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS*" /label="scoC CDS" gene complement(973675..974286) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /label="scoC gene" S_feature 973679..974444 /Source="Nicolas_S_feature" /locus_tag="new_1073110_1073875" /HighExp="Lbstat, Etha, T0.30H, Gly, M0t90, M40t90, M40t45, M0t45, H2O2, dia15" /AntisenseName="scoC" /AntisenseCor="-0.46322626361720198" /AntisenseRegPval="-15" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S352" downshifts complement(973751) /Source="Nicolas_upshifts" /id="D539" /incds=1 /nref=1 /ntot=81 /MaxReadThrough="5.81117" /MaxDrop="2.1632" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" promotor_-35 974282..974286 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 974294..974307 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 974306 /Source="Nicolas_upshifts" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(974311..974330) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-10" upshifts complement(974334) /Source="Nicolas_upshifts" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="upshifts" promotor_-35 complement(974345..974348) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-35" downshifts 974401 /Source="Nicolas_upshifts" /id="D540" /incds=0 /nref=1 /ntot=124 /MaxReadThrough="3.007" /MaxDrop="2.86547" /score="17.8486533" /energy="-7.1" /TU="U799,U800" /idTUdmin="U799" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(974464..974820) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11429463; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein; acid tolerance protein" /protein_id="NP_388881.1" /db_xref="EnsemblGenomes-Gn:BSU10000" /db_xref="EnsemblGenomes-Tr:CAB12840" /db_xref="GOA:O07516" /db_xref="InterPro:IPR024623" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12984" /db_xref="UniProtKB/Swiss-Prot:O07516" /translation="MASGRSLLTGLFVGGIIGGAAVLLTAPSSGKQLREKMKTNYDSF EETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEI ADIEEKIRQLEKTLQN*" /label="yhaH CDS" gene complement(974464..974820) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /label="yhaH gene" downshifts complement(974468) /Source="Nicolas_upshifts" /id="D541" /incds=0 /nref=254 /ntot=287 /MaxReadThrough="1.65317" /MaxDrop="7.37381" /score="10.8990112" /energy="-7.9" /TU="NA" /idTUdmin="U804" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 974897..974902 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(974903..974922) /Source="Nicolas_upshift_promotors" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(974917) /Source="Nicolas_upshifts" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 974918..974936 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 974918 /Source="Nicolas_upshifts" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(974919..975182) /Source="Nicolas_S_feature" /locus_tag="new_1074350_1074613_c" /HighExp="Etha, Salt, HiTm, Heat, Diami, Sw, Gly, S1, MG 10, MG 60" /AntisenseName="yhzF" /AntisenseCor="-0.69425315975357205" /AntisenseRegPval="-39.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S353" CDS 974950..975141 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="membrane protein of unknown function" /protein_id="YP_003097700.1" /db_xref="EnsemblGenomes-Gn:BSU10009" /db_xref="EnsemblGenomes-Tr:CAX52588" /db_xref="GOA:C0H3Y3" /db_xref="UniProtKB/Swiss-Prot:C0H3Y3" /translation="MSVFLIVLSCITLAFASGAVYYIKLLSQAASYPPKRVIRQKALV CSTGTAFTLCLIFFTKLLA*" /label="yhzF CDS" gene 974950..975141 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /label="yhzF gene" S_feature 975142..976577 /Source="Nicolas_S_feature" /locus_tag="new_1074573_1076008" /HighExp="S3, S8, S4, S6, S7, T5.0H, C30, S5, T4.0H, T3.30H" /AntisenseName="trpP" /AntisenseCor="-0.20038256384636899" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S354" CDS complement(975215..975733) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735881, 14702295, 15849754, 16850406, 16879415, 17114263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735881, 14702295, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="tryptophan transporter or sensor" /protein_id="NP_388882.2" /db_xref="EnsemblGenomes-Gn:BSU10010" /db_xref="EnsemblGenomes-Tr:CAB12841" /db_xref="GOA:O07515" /db_xref="InterPro:IPR031360" /db_xref="SubtiList:BG12983" /db_xref="UniProtKB/Swiss-Prot:O07515" /translation="MKTKELVIMALFAAIGAALHSIIPPFLGGMKPDMMLIMMFMGIL LFPRVQNVLVIGIVTGIISALTTAFPAGQIPNIIDKPVSAFLFFSLFLLFRKSRKTGA AAVLTVIGTILSGIVFLSSALLIVGLPGGFAALFAAVVLPAAVLNTISMIIIYPIVQT ILRRSSFMEAAK*" /label="trpP CDS" gene complement(975215..975733) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /label="trpP gene" downshifts complement(975227) /Source="Nicolas_upshifts" /id="D542" /incds=0 /nref=105 /ntot=253 /MaxReadThrough="6.00956" /MaxDrop="4.62812" /score="24.5949542" /energy="-12.8" /TU="U804,U805,U806" /idTUdmin="U804" /TUdmin="-750" /isTUend="FALSE" /label="downshifts" S_feature complement(975734..975821) /Source="Nicolas_S_feature" /locus_tag="new_1075165_1075252_c" /HighExp="C90, B60, S1, GM 15, MG 45, MG-0.2, Etha, Lbtran, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S355" promotor_-10 complement(975813..975832) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(975821) /Source="Nicolas_upshifts" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(975846..975853) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(975858..976937) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /EC_number="2.6.1.52" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4337849, 16233211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4337849, 16233211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine aminotransferase" /protein_id="NP_388883.1" /db_xref="EnsemblGenomes-Gn:BSU10020" /db_xref="EnsemblGenomes-Tr:CAB12842" /db_xref="GOA:P80862" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR022278" /db_xref="SubtiList:BG12673" /db_xref="UniProtKB/Swiss-Prot:P80862" /translation="MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSK EYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAW SEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANV PKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCI DESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRAS IYNAVSLEDCEKLAAFMKKFQQENE*" /label="serC CDS" gene complement(975858..976937) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /label="serC gene" misc_feature complement(976976..976995) /Source="Nicolas_upshift_promotors" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(976987) /Source="Nicolas_upshifts" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(976989..977070) /Source="Nicolas_S_feature" /locus_tag="new_1076420_1076501_c" /HighExp="Etha, dia15, H2O2, LBGtran, G135, G180, dia5, G150, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S356" CDS complement(977084..977521) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /EC_number="3.6.1.29" /EC_number="3.6.1.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579061, 15703176, 16934294, 17217311, 26181368, 28516732; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous Hit-family phosphohydrolase, adenosine phosphoramidase" /protein_id="NP_388884.1" /db_xref="EnsemblGenomes-Gn:BSU10030" /db_xref="EnsemblGenomes-Tr:CAB12843" /db_xref="GOA:O07513" /db_xref="InterPro:IPR001310" /db_xref="InterPro:IPR011146" /db_xref="InterPro:IPR019808" /db_xref="InterPro:IPR036265" /db_xref="PDB:1Y23" /db_xref="SubtiList:BG12607" /db_xref="UniProtKB/Swiss-Prot:O07513" /translation="MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLV IPKTHIENVYEFTDELAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEKAGQSVFHYH MHIIPRYGKGDGFGAVWKTHADDYKPEDLQNISSSIAKRLASS*" /label="hinT CDS" gene complement(977084..977521) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /label="hinT gene" downshifts complement(977115) /Source="Nicolas_upshifts" /id="D543" /incds=0 /nref=187 /ntot=248 /MaxReadThrough="4.31506" /MaxDrop="5.61862" /score="-0.366845751" /energy="-8.6" /TU="U806" /idTUdmin="U807" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(977554..977573) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(977568) /Source="Nicolas_upshifts" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" downshifts 977571 /Source="Nicolas_upshifts" /id="D544" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.3752" /MaxDrop="3.02008" /score="-3.56654132" /energy="-13.3" /TU="NA" /idTUdmin="U803" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(977587..977594) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(977593..977889) /Source="Nicolas_S_feature" /locus_tag="new_1077024_1077320_c" /HighExp="S7, S8, S6, S5, BT, ferm, nit, G/S, S4, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S357" downshifts complement(977636) /Source="Nicolas_upshifts" /id="D545" /incds=0 /nref=40 /ntot=72 /MaxReadThrough="3.07347" /MaxDrop="7.69075" /score="9.88617558" /energy="-14.2" /TU="U807" /idTUdmin="U807" /TUdmin="-517" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(977887..977898) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(977893) /Source="Nicolas_upshifts" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(977913..977919) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 977949..977956 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 977970..977989 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 977979 /Source="Nicolas_upshifts" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="upshifts" CDS 978009..978752 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 11807061, 18599827, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 11807061, 18599827, 26735940; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein)" /protein_id="NP_388885.1" /db_xref="EnsemblGenomes-Gn:BSU10040" /db_xref="EnsemblGenomes-Tr:CAB12844" /db_xref="GOA:P55339" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11516" /db_xref="UniProtKB/Swiss-Prot:P55339" /translation="MSLLSVKDLTGGYTRNPVLKNVSFTLEPNQIVGLIGLNGAGKST TIRHIIGLMDPHKGSIELNGKTFAEDPEGYRSQFTYIPETPVLYEELTLMEHLELTAM AYGLSKETMEKRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLAEPALYIIDE PFLGLDPLAINALLERMNEAKKGGASVLMSTHILATAERYCDSFIILHNGEVRARGTL SELREQFGMKDAALDDLYLELTKEDAGHE*" /label="ecsA CDS" gene 978009..978752 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /label="ecsA gene" CDS 978745..979971 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease subunit)" /protein_id="NP_388886.1" /db_xref="EnsemblGenomes-Gn:BSU10050" /db_xref="EnsemblGenomes-Tr:CAB12845" /db_xref="GOA:P55340" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG11517" /db_xref="UniProtKB/Swiss-Prot:P55340" /translation="MNNMLDIWQSRLQEHIKETRTYMKYMLNDHLVIVLIFFLAGAAS WYSKWIRDIPAHFPSFWVMAVLFSLVLTSSYVRTLLKEADLVFLLPLEAKMEPYLKQA FVYSYVSQLFPLIALSIVAMPLYFAVTPGASLVSYAAVFVQLLLLKAWNQVMEWRTTF QNDRSMKRMDVIIRFAANTLVLYFVFQSVYMYALLVYVIMAVLYLYMSSAAKRKTFKW ESHIESELRRKQRFYRIANLFTDVPHLRKQAKRRAYLDFLLRLVPFEQRKTFAYMFTR AFLRSSDYLGILVRLTIVFALIIMYVSASPLIAAVLTVFAIFITGIQLLPLFGHFDHL ALQELYPVQKETKLKSYFSLLKTALSIQALLMSVASAYAAGLTGFLYALIGSAVLIFV VLPAYMTTRLKKHGKL*" /label="ecsB CDS" gene 978745..979971 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /label="ecsB gene" promotor_-10 complement(979304..979322) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(979319) /Source="Nicolas_upshifts" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(979338..979343) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 979991..980701 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8581172, 10027970; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388887.1" /db_xref="EnsemblGenomes-Gn:BSU10060" /db_xref="EnsemblGenomes-Tr:CAB12846" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG11518" /db_xref="UniProtKB/Swiss-Prot:P55341" /translation="MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKI HTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGT GAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRK SLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLG ETARHVFHLRILKETAGE*" /label="ecsC CDS" gene 979991..980701 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /label="ecsC gene" downshifts 980665 /Source="Nicolas_upshifts" /id="D546" /incds=0 /nref=78 /ntot=231 /MaxReadThrough="1.36097" /MaxDrop="4.78417" /score="28.5337351" /energy="-14.6" /TU="NA" /idTUdmin="U808" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(980719..981909) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /EC_number="3.5.1.-" /experiment="publication(s) with functional evidences, PMID:23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl amino acid acetylase, promiscuous activity" /protein_id="NP_388888.2" /db_xref="EnsemblGenomes-Gn:BSU10070" /db_xref="EnsemblGenomes-Tr:CAB12847" /db_xref="GOA:O07598" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12982" /db_xref="UniProtKB/Swiss-Prot:O07598" /translation="MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAF IASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVP GVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLE NTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGS QIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILE KEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQ MGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAIT YHQL*" /label="sndC CDS" gene complement(980719..981909) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /label="sndC gene" downshifts complement(980729) /Source="Nicolas_upshifts" /id="D547" /incds=0 /nref=11 /ntot=162 /MaxReadThrough="3.12546" /MaxDrop="4.15559" /score="-4.78420642" /energy="-14.6" /TU="U810" /idTUdmin="U811" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(980794) /Source="Nicolas_upshifts" /id="D548" /incds=1 /nref=25 /ntot=206 /MaxReadThrough="4.92378" /MaxDrop="3.21645" /score="-4.78420642" /energy="-14.6" /TU="U810,U811" /idTUdmin="U811" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(981933..981952) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(981954) /Source="Nicolas_upshifts" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(981966..981971) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(981982..983373) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 12107147; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388889.1" /db_xref="EnsemblGenomes-Gn:BSU10080" /db_xref="EnsemblGenomes-Tr:CAB12848" /db_xref="GOA:O07599" /db_xref="SubtiList:BG13047" /db_xref="UniProtKB/Swiss-Prot:O07599" /translation="MMEVGILPVHVLYVFFIGAIILFMLLRKDTTFISLFGIFIISLW ASHSLSASVSSLFHSFIYAAGELLPTIFIICFIVSMSDLLTKTGINEAMISPFASLVR GPVTAYWLIGGLMFAISLFFWPSPGVALIGAVLLPAAARAGLTPLAAAMAMNLFGHGF ALSGDFVIQAAPKLTADAAGIPVGDVVSASIPLVLIMGVTTTTAAFIMIQRERKKQEH PTSFSPVLSGEQDNSLYLPKRLRSILAFLIPLAFLADIACMLLFNLQGNDATALIGGS AICILFTVHFFVYKHKGLEKITGYFIDGFKFGFKVFGPVIPIAAFFYLGDSGYESILG TSLPKGSHGIVNDLGIALSHMMPMSKELAATALTAAGAITGLDGSGFSGISLAGSIAK LFSSALHADPAILTALGQISAIWVGGGTLVPWALIPAAAICKVDPFELARKNFIPVAI GLLVTTLAAVMML*" /label="yhfA CDS" gene complement(981982..983373) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /label="yhfA gene" promotor_-10 complement(983384..983403) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(983389) /Source="Nicolas_upshifts" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(983416..983425) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(983439..983753) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388890.1" /db_xref="EnsemblGenomes-Gn:BSU10090" /db_xref="EnsemblGenomes-Tr:CAB12849" /db_xref="SubtiList:BG10426" /db_xref="UniProtKB/Swiss-Prot:P38048" /translation="MKHTCPVCGFKDWLNRHMIMKAIILMKSARAAVFSSDLMSTRCS TRITHIEPSESIIAYRKNWLAEGCVIFSPECFPKHLQKANRGLRHHLIEQLKQINVHL PS*" /label="yhgB CDS" gene complement(983439..983753) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /label="yhgB gene" CDS complement(983798..984298) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /EC_number="1.14.99.48" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21873409, 22531134, 24582752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21873409, 22531134, 24582752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388891.1" /db_xref="EnsemblGenomes-Gn:BSU10100" /db_xref="EnsemblGenomes-Tr:CAB12850" /db_xref="GOA:P38049" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:4OZ5" /db_xref="SubtiList:BG10427" /db_xref="UniProtKB/Swiss-Prot:P38049" /translation="MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDT VFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAI RVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVT TYFAVE*" /label="hmoB CDS" gene complement(983798..984298) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /label="hmoB gene" downshifts complement(983825) /Source="Nicolas_upshifts" /id="D549" /incds=0 /nref=145 /ntot=254 /MaxReadThrough="3.45185" /MaxDrop="5.6374" /score="15.5142908" /energy="-14.8" /TU="U812" /idTUdmin="U812" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(984311..984330) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 984313..984317 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(984332) /Source="Nicolas_upshifts" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 984333..984352 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 984334 /Source="Nicolas_upshifts" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(984347..984348) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 984365..984371 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 984386..984397 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 984391 /Source="Nicolas_upshifts" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="upshifts" CDS 984420..986564 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8335642, 11567005, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8335642, 11567005, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2C (1F class) required for spore germination" /protein_id="NP_388892.2" /db_xref="EnsemblGenomes-Gn:BSU10110" /db_xref="EnsemblGenomes-Tr:CAB12851" /db_xref="GOA:P38050" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10428" /db_xref="UniProtKB/Swiss-Prot:P38050" /translation="MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLI LHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSV GRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKL LEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDK NKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDK YSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGV EAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDY TPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALA LGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQT SWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAV WMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKT LTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANL FSGASYKIVPYNTQTKREGEGTDYVQPKLFSS*" /label="pbpF CDS" gene 984420..986564 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /label="pbpF gene" promotor_-10 complement(984464..984475) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(984467) /Source="Nicolas_upshifts" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(984489..984495) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 986601..986607 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 986621..986640 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 986631 /Source="Nicolas_upshifts" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" CDS 986686..987747 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /EC_number="4.1.1.37" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 17122346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 17122346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III decarboxylase" /protein_id="NP_388893.1" /db_xref="EnsemblGenomes-Gn:BSU10120" /db_xref="EnsemblGenomes-Tr:CAB12852" /db_xref="GOA:P32395" /db_xref="InterPro:IPR000257" /db_xref="InterPro:IPR006361" /db_xref="PDB:2INF" /db_xref="SubtiList:BG10429" /db_xref="UniProtKB/Swiss-Prot:P32395" /translation="MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEK YGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQ PIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQAD YRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARS KGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLK KLTAFVHEYSQNKKMGQYS*" /label="hemE CDS" gene 986686..987747 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /label="hemE gene" CDS 987819..988751 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /EC_number="4.99.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferrochelatase" /protein_id="NP_388894.1" /db_xref="EnsemblGenomes-Gn:BSU10130" /db_xref="EnsemblGenomes-Tr:CAB12853" /db_xref="GOA:P32396" /db_xref="InterPro:IPR001015" /db_xref="InterPro:IPR019772" /db_xref="InterPro:IPR033644" /db_xref="InterPro:IPR033659" /db_xref="PDB:1AK1" /db_xref="PDB:1C1H" /db_xref="PDB:1C9E" /db_xref="PDB:1DOZ" /db_xref="PDB:1FJI" /db_xref="PDB:1LD3" /db_xref="PDB:1N0I" /db_xref="PDB:2AC2" /db_xref="PDB:2AC4" /db_xref="PDB:2H1V" /db_xref="PDB:2H1W" /db_xref="PDB:2HK6" /db_xref="PDB:2Q2N" /db_xref="PDB:2Q2O" /db_xref="PDB:2Q3J" /db_xref="PDB:3GOQ" /db_xref="PDB:3M4Z" /db_xref="SubtiList:BG10430" /db_xref="UniProtKB/Swiss-Prot:P32396" /translation="MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLK DRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHK DGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDR VKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAV GWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVV TDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR*" /label="hemH CDS" gene 987819..988751 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /label="hemH gene" CDS 988766..990178 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /EC_number="1.3.3.4" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9217019, 9784236, 10498703, 20543190" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9217019, 9784236, 10498703, 20543190; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous protoporphyrinogen IX and coproporphyrinogen III oxidase" /protein_id="NP_388895.1" /db_xref="EnsemblGenomes-Gn:BSU10140" /db_xref="EnsemblGenomes-Tr:CAB12854" /db_xref="GOA:P32397" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR004572" /db_xref="InterPro:IPR036188" /db_xref="PDB:3I6D" /db_xref="SubtiList:BG10431" /db_xref="UniProtKB/Swiss-Prot:P32397" /translation="MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASP RVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRT LHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRV GDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQ LTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTL DADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVI SRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLK KVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGI PDCIDQGKAAVSDALTYLFS*" /label="hemY CDS" gene 988766..990178 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /label="hemY gene" downshifts 988769 /Source="Nicolas_upshifts" /id="D550" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="7.68191" /MaxDrop="2.667" /score="28.7532434" /energy="-11.6" /TU="U813,U816" /idTUdmin="U814" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 990155 /Source="Nicolas_upshifts" /id="D551" /incds=0 /nref=195 /ntot=254 /MaxReadThrough="2.9859" /MaxDrop="6.7703" /score="28.7532434" /energy="-11.6" /TU="NA" /idTUdmin="U813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 990239..990246 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 990260..990279 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 990265 /Source="Nicolas_upshifts" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" CDS 990324..990899 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15944459, 23695570; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown target" /protein_id="NP_388896.1" /db_xref="EnsemblGenomes-Gn:BSU10150" /db_xref="EnsemblGenomes-Tr:CAB12855" /db_xref="GOA:P32398" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10432" /db_xref="UniProtKB/Swiss-Prot:P32398" /translation="MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTF FKNKEELFDEIFTTLLKEMKQKADEAMEPSLPFHENVHRALFAILEFRKTHQLTIKIF QENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKLYIAL IFDWEKQHPPLDKETIAGLLELYVVKGLSAN*" /label="yhgD CDS" gene 990324..990899 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /label="yhgD gene" promotor_-35 990643..990646 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 990661 /Source="Nicolas_upshifts" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 990663..990682 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 990900..990969 /Source="Nicolas_S_feature" /locus_tag="new_1090331_1090400" /HighExp="G135, G150, G180, BI, Salt, Etha, Cold, Heat, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.731, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S358" CDS 990970..993297 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576783; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting protein" /protein_id="NP_388897.1" /db_xref="EnsemblGenomes-Gn:BSU10160" /db_xref="EnsemblGenomes-Tr:CAB12856" /db_xref="GOA:P32399" /db_xref="InterPro:IPR017500" /db_xref="InterPro:IPR017501" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR023908" /db_xref="SubtiList:BG10433" /db_xref="UniProtKB/Swiss-Prot:P32399" /translation="MNTIRSQWKDIVTSKKLLIPIIAILFVPLIYSGVFLKAYWDPYG TVDQLPVVVVNQDKGATYEGEKLQIGDDLVKELKDNNNFDWHFSNDLDQSLKDLLNQK YYLVVEIPEDFSKNASTVLDKNPKKLDLKYHTNAGSNYVGATIGEKAIDKLKASVSKE VTEQYTKVIFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATI SDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLA GLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETA MKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQ ILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEG ADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSK QVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPV KTKDDAIHSVPNYGTGLTPYILSMGLYVGGIMLTVVFPLKEASGRPRNGFEWFFSKFN VMMLVGIIQSLIVATVLLLGIGLEVESTWRFYVFTIITSLAFLAIIQFLATTMGNPGR FIAVIILVLQLGASGGTFPLELLPNFYQVIHGALPMTYSINGFRAVISNGDFGYMWQM AGVLIGIALVMIALSITYFTMLSRKEETSEEQPAS*" /label="yhgE CDS" gene 990970..993297 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /label="yhgE gene" downshifts 993279 /Source="Nicolas_upshifts" /id="D552" /incds=0 /nref=65 /ntot=211 /MaxReadThrough="0.57274" /MaxDrop="5.58483" /score="-4.79013797" /energy="-7.3" /TU="NA" /idTUdmin="U817" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(993339..994316) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 21383089, 21542858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 21383089, 21542858; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 2" /protein_id="NP_388898.1" /db_xref="EnsemblGenomes-Gn:BSU10170" /db_xref="EnsemblGenomes-Tr:CAB12857" /db_xref="GOA:O07600" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13048" /db_xref="UniProtKB/Swiss-Prot:O07600" /translation="MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERR IADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWE STGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREV YKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVE HYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM*" /label="fabHB CDS" gene complement(993339..994316) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /label="fabHB gene" downshifts complement(993352) /Source="Nicolas_upshifts" /id="D553" /incds=0 /nref=21 /ntot=217 /MaxReadThrough="1.99012" /MaxDrop="7.90433" /score="-9.17544275" /energy="-7.3" /TU="NA" /idTUdmin="U819" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(994330..994349) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(994348) /Source="Nicolas_upshifts" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(994363..994369) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 994375..994383 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 994394..994412 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 994401 /Source="Nicolas_upshifts" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 994443..995219 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388899.1" /db_xref="EnsemblGenomes-Gn:BSU10180" /db_xref="EnsemblGenomes-Tr:CAB12858" /db_xref="GOA:O07601" /db_xref="InterPro:IPR011397" /db_xref="SubtiList:BG13049" /db_xref="UniProtKB/Swiss-Prot:O07601" /translation="MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGAL TFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFM KRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALL PIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFN VPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ*" /label="yhfC CDS" gene 994443..995219 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /label="yhfC gene" S_feature complement(994935..995556) /Source="Nicolas_S_feature" /locus_tag="new_1094366_1094987_c" /HighExp="B36, BT, B60, Pyr, S8, G/S, G135, Mal, M/G, Glucon" /AntisenseName="yhfC" /AntisenseCor="-0.12937903461570099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="0.51248700000000003" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S359" S_feature 995220..995591 /Source="Nicolas_S_feature" /locus_tag="new_1094651_1095022" /HighExp="Lbstat, S2, M0t90, M40t90, HiOs, SMMPr, T-2.40H, Etha, Lbtran, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48518699999999998" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S360" promotor_-10 complement(995534..995553) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(995555) /Source="Nicolas_upshifts" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(995567..995576) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 995569..995576 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 995591..995610 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 995593 /Source="Nicolas_upshifts" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 995632..996672 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15713475, 15743956; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminopeptidase" /protein_id="NP_388901.1" /db_xref="EnsemblGenomes-Gn:BSU10200" /db_xref="EnsemblGenomes-Tr:CAB12860" /db_xref="GOA:O07603" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13051" /db_xref="UniProtKB/Swiss-Prot:O07603" /translation="MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVR NHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEY CQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIG VGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNN EEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQ LAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTA KLLYYYVQSPMV*" /label="yhfE CDS" gene 995632..996672 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /label="yhfE gene" CDS 996685..997092 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11157739, 14517985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding PUA-containing enzyme" /protein_id="NP_388902.1" /db_xref="EnsemblGenomes-Gn:BSU10210" /db_xref="EnsemblGenomes-Tr:CAB12861" /db_xref="InterPro:IPR007374" /db_xref="InterPro:IPR009326" /db_xref="InterPro:IPR015947" /db_xref="SubtiList:BG13052" /db_xref="UniProtKB/Swiss-Prot:O07604" /translation="MKIYKLKSTFGWEGDDGLGEQLIQQILAGEKSATCAPKSLYSKD ELRDVYQTAGQLVTVYDKHDNPRCNIKVTDVFETTFGAPDMRLVKGEGNGDRIEEFQE DHRMAWAELIKSGELELNEDTVLITELFVLVKD*" /label="yhfF CDS" gene 996685..997092 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /label="yhfF gene" downshifts 997063 /Source="Nicolas_upshifts" /id="D554" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="0.87656" /MaxDrop="5.21108" /score="22.0862441" /energy="-20.3" /TU="U822" /idTUdmin="U822" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(997129..998418) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/sodium-glutamate (aspartate) symport permease" /protein_id="NP_388903.1" /db_xref="EnsemblGenomes-Gn:BSU10220" /db_xref="EnsemblGenomes-Tr:CAB12862" /db_xref="GOA:O07605" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12595" /db_xref="UniProtKB/Swiss-Prot:O07605" /translation="MKRIKFGLATQIFVGLILGVIVGVIWYGNPALPTYLQPIGDLFL RLIKMIVIPIVVSSLIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFH PGTGVNIHEAQKSDISQYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFT VLFALGISAIGERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGS LISLGKLVGLVYVALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVL PRIMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQIT LVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTG NALAAVVMSKWEGMFNPAKAETVMSQSKTEQNATISG*" /label="gltT CDS" gene complement(997129..998418) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /label="gltT gene" downshifts complement(997159) /Source="Nicolas_upshifts" /id="D555" /incds=0 /nref=226 /ntot=280 /MaxReadThrough="2.99263" /MaxDrop="7.79183" /score="48.7726082" /energy="-21.9" /TU="U823" /idTUdmin="U824" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(998419..998519) /Source="Nicolas_S_feature" /locus_tag="new_1097850_1097950_c" /HighExp="C90, LoTm, LBGexp, Cold, UNK1, BC, dia5, Lbexp, S1, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S361" promotor_-10 complement(998518..998537) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(998519) /Source="Nicolas_upshifts" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(998521..998657) /Source="Nicolas_S_feature" /locus_tag="new_1097952_1098088_c" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, T2.30H, T5.0H, Cold, T2.0H, S0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S362" promotor_-35 complement(998552..998558) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(998689..998829) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388904.1" /db_xref="EnsemblGenomes-Gn:BSU10230" /db_xref="EnsemblGenomes-Tr:CAB12863" /db_xref="InterPro:IPR025432" /db_xref="SubtiList:BG13053" /db_xref="UniProtKB/Swiss-Prot:O07606" /translation="MVMLGKITEFFRNLPSKKCAECGKKIEEQHECYGNICNDCIKVN DL*" /label="yhfH CDS" gene complement(998689..998829) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /label="yhfH gene" downshifts complement(998702) /Source="Nicolas_upshifts" /id="D556" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.70702" /MaxDrop="4.73949" /score="28.7665297" /energy="-13.6" /TU="U824" /idTUdmin="U824" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(998848..998867) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(998867) /Source="Nicolas_upshifts" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(998880..998887) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 998911..998917 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 998931..998950 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 998934 /Source="Nicolas_upshifts" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="upshifts" CDS 998981..999715 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388905.1" /db_xref="EnsemblGenomes-Gn:BSU10240" /db_xref="EnsemblGenomes-Tr:CAB12864" /db_xref="GOA:O07607" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13054" /db_xref="UniProtKB/Swiss-Prot:O07607" /translation="MKVTVIGCYGGFPAANEATSGYLFQSGDYSLLVDCGSAVLSKLF GYVPAEKLDAVVLSHYHHDHIADIGPLQFAKQVGSFLGKGEHTLPIYGHDADIEQFQK LTYKTHTKGIAYQPDQPLTAGPFTITFLKTIHPVTCYAMRITDGSHTVVYTADSSYQD SFIPFSKDADLLISECNFYADQDGTSAGHMNSLEAGRIAKEAGAGELLLTHLPHFGVH DNLRKEAKTVFNGEVNIAKSGFVWEG*" /label="yhfI CDS" gene 998981..999715 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /label="yhfI gene" CDS 999728..1000723 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /EC_number="6.3.1.20" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoate-protein ligase" /protein_id="NP_388906.1" /db_xref="EnsemblGenomes-Gn:BSU10250" /db_xref="EnsemblGenomes-Tr:CAB12865" /db_xref="GOA:O07608" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004562" /db_xref="InterPro:IPR019491" /db_xref="SubtiList:BG13055" /db_xref="UniProtKB/Swiss-Prot:O07608" /translation="MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIII GKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKF TEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVV SALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEY KLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDC KIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY*" /label="lplJ CDS" gene 999728..1000723 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /label="lplJ gene" CDS 1000788..1001432 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11790741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-binding epimerase / hydratase" /protein_id="NP_388907.1" /db_xref="EnsemblGenomes-Gn:BSU10260" /db_xref="EnsemblGenomes-Tr:CAB12866" /db_xref="GOA:O07609" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13056" /db_xref="UniProtKB/Swiss-Prot:O07609" /translation="MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQKASLEAA GAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAI AGIKRFIMVSALQAHNRENWNEALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPG TGTVSAAKDLERGFISRDDVAKTVIASLDEKNTENRAFDLTEGDTPIAEALKKL*" /label="yhfK CDS" gene 1000788..1001432 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /label="yhfK gene" downshifts 1001420 /Source="Nicolas_upshifts" /id="D557" /incds=0 /nref=239 /ntot=258 /MaxReadThrough="0.56809" /MaxDrop="6.84076" /score="18.2092404" /energy="-10" /TU="NA" /idTUdmin="U825" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1001460..1001463 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1001478..1001497 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1001485 /Source="Nicolas_upshifts" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="upshifts" CDS 1001549..1003090 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long-chain fatty-acid-CoA ligase (degradative)" /protein_id="NP_388908.2" /db_xref="EnsemblGenomes-Gn:BSU10270" /db_xref="EnsemblGenomes-Tr:CAB12867" /db_xref="GOA:O07610" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13057" /db_xref="UniProtKB/Swiss-Prot:O07610" /translation="MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQ EAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAI VGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAK QNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPM FHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHEN GKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRK PGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWL YTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQ SGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALR DILPQ*" /label="lcfB CDS" gene 1001549..1003090 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /label="lcfB gene" downshifts 1003070 /Source="Nicolas_upshifts" /id="D558" /incds=0 /nref=5 /ntot=108 /MaxReadThrough="2.74134" /MaxDrop="3.72638" /score="15.3712924" /energy="-10.4" /TU="NA" /idTUdmin="U826" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1003129..1003524) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388909.1" /db_xref="EnsemblGenomes-Gn:BSU10280" /db_xref="EnsemblGenomes-Tr:CAB12868" /db_xref="SubtiList:BG13058" /db_xref="UniProtKB/Swiss-Prot:O07611" /translation="MKKIVAAIVVIGLVFIAFFYLYSRSGDVYQSVDADLITLSSSGQ EDIEIEKRQHVKDMLDIMNQGKQVKTEKTSAPDYEGTIKFHKDRYDSFRLWIDGSQQA VFLKDGTYYKLSKNDTKALLNIIKKEAKD*" /label="yhfM CDS" gene complement(1003129..1003524) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /label="yhfM gene" downshifts complement(1003146) /Source="Nicolas_upshifts" /id="D559" /incds=0 /nref=46 /ntot=89 /MaxReadThrough="0.75539" /MaxDrop="6.88759" /score="17.4775611" /energy="-10.4" /TU="NA" /idTUdmin="U827" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1003544..1003555) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1003548) /Source="Nicolas_upshifts" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1003570..1003576) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1003609..1003612 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1003620 /Source="Nicolas_upshifts" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1003627..1003646 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1003673..1004953 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /EC_number="3.4.24.84" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9015299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane metalloprotease" /protein_id="NP_388910.1" /db_xref="EnsemblGenomes-Gn:BSU10290" /db_xref="EnsemblGenomes-Tr:CAB12869" /db_xref="GOA:P40769" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR027057" /db_xref="InterPro:IPR032456" /db_xref="SubtiList:BG11029" /db_xref="UniProtKB/Swiss-Prot:P40769" /translation="MRKWIAAAGLAYVLYGLFFYWYFFLSGDSAIPEAVKGTQADPAS FMKPSELAVAEQYSNVKNFLFFIGVPLDWFLFFVLLVSGVSKKIKKWIEAAVPFRFLQ TVGFVFVLSLITTLVTLPLDWIGYQVSLDYNISTQTTASWAKDQVISFWISFPIFTLC VLVFYWLIKRHEKKWWLYAWLLTVPFSLFLFFIQPVIIDPLYNDFYPLKNKELESKIL ELADEANIPADHVYEVNMSEKTNALNAYVTGIGANKRIVLWDTTLNKLDDSEILFIMG HEMGHYVMKHVYIGLAGYLLVSLAGFYVIDKLYKRTVRLTRSMFHLEGRHDLAALPLL LLLFSVLSFAVTPFSNAVSRYQENKADQYGIELTENREAAVKTFQDLAVTGLSQVDPP VLVKIFRGSHPSIMERIQHAEKEENAPEHQDADK*" /label="yhfN CDS" gene 1003673..1004953 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /label="yhfN gene" promotor_-10 complement(1004100..1004119) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1004114) /Source="Nicolas_upshifts" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1004135..1004140) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1004940 /Source="Nicolas_upshifts" /id="D560" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="3.82026" /MaxDrop="3.6342" /score="6.45541384" /energy="-12.7" /TU="U828" /idTUdmin="U828" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(1004990) /Source="Nicolas_upshifts" /id="D561" /incds=0 /nref=129 /ntot=219 /MaxReadThrough="-0.11848" /MaxDrop="9.02627" /score="-6.76069514" /energy="-7.8" /TU="NA" /idTUdmin="U830" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1004992..1006137) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /EC_number="3.4.21.62" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine alkaline protease (Ca(2+)-dependent subtilisin E)" /protein_id="NP_388911.2" /db_xref="EnsemblGenomes-Gn:BSU10300" /db_xref="EnsemblGenomes-Tr:CAB12870" /db_xref="GOA:P04189" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="PDB:1SCJ" /db_xref="PDB:3WHI" /db_xref="SubtiList:BG10190" /db_xref="UniProtKB/Swiss-Prot:P04189" /translation="MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFK QTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHI AHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSE TNPYQDGSSHGTHVAGTIAALNNSIGVLGVAPSASLYAVKVLDSTGSGQYSWIINGIE WAISNNMDVINMSLGGPTGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSTSTVGYPAK YPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVA GAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ*" /label="aprE CDS" gene complement(1004992..1006137) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /label="aprE gene" S_feature complement(1006138..1006204) /Source="Nicolas_S_feature" /locus_tag="new_1105569_1105635_c" /HighExp="BC, T5.0H, LoTm, Sw, T4.0H, T3.30H, S1, T3.0H, S2, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S363" promotor_-10 complement(1006193..1006212) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1006210) /Source="Nicolas_upshifts" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1006228..1006232) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1006517..1006524 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-35" promotor_-10 1006539..1006558 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-10" upshifts 1006541 /Source="Nicolas_upshifts" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="upshifts" CDS 1006572..1007021 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /EC_number="2.3.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388912.1" /db_xref="EnsemblGenomes-Gn:BSU10310" /db_xref="EnsemblGenomes-Tr:CAB12871" /db_xref="GOA:O07614" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13059" /db_xref="UniProtKB/Swiss-Prot:O07614" /translation="MNIRQAKTSDAAAIAPLFNQYREFYRQASDLQGAEAFLKARLEN HESVILIAEENGEFIGFTQLYPTFSSVSMKRIYILNDLFVVPHARTKGAGGRLLSAAK DYAGQNGAKCLTLQTEHHNRKARSLYEQNGYEEDTGFVHYCLNVPAK*" /label="yhfO CDS" gene 1006572..1007021 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /label="yhfO gene" promotor_-35 1007037..1007044 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1007059..1007078 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1007066 /Source="Nicolas_upshifts" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1007093..1008085 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9643546, 12057962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388913.1" /db_xref="EnsemblGenomes-Gn:BSU10320" /db_xref="EnsemblGenomes-Tr:CAB12872" /db_xref="GOA:O07615" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014188" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="PDB:1TT7" /db_xref="PDB:1Y9E" /db_xref="SubtiList:BG13060" /db_xref="UniProtKB/Swiss-Prot:O07615" /translation="MSTLFQALQAEKNADDVSVHVKTISTEDLPKDGVLIKVAYSGIN YKDGLAGKAGGNIVREYPLILGIDAAGTVVSSNDPRFAEGDEVIATSYELGVSRDGGL SEYASVPGDWLVPLPQNLSLKEAMVYGTAGFTAALSVHRLEQNGLSPEKGSVLVTGAT GGVGGIAVSMLNKRGYDVVASTGNREAADYLKQLGASEVISREDVYDGTLKALSKQQW QGAVDPVGGKQLASLLSKIQYGGSVAVSGLTGGGEVPATVYPFILRGVSLLGIDSVYC PMDVRAAVWERMSSDLKPDQLLTIVDREVSLEETPGALKDILQNRIQGRVIVKL*" /label="yhfP CDS" gene 1007093..1008085 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /label="yhfP gene" downshifts 1008086 /Source="Nicolas_upshifts" /id="D562" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="4.4421" /MaxDrop="2.9095" /score="14.183693" /energy="-15.3" /TU="U831,U832" /idTUdmin="U831" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" S_feature 1008131..1008241 /Source="Nicolas_S_feature" /locus_tag="new_1107562_1107672" /HighExp="Etha, dia15, LoTm, Salt, H2O2, LBGexp, Diami, Paraq, dia5, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S364" promotor_-35 1008219..1008226 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1008242..1008261 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1008243 /Source="Nicolas_upshifts" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1008302..1009273 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16672620, 20147287; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III) siderophore-binding lipoprotein" /protein_id="NP_388914.2" /db_xref="EnsemblGenomes-Gn:BSU10330" /db_xref="EnsemblGenomes-Tr:CAB12873" /db_xref="GOA:C0SP94" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG13061" /db_xref="UniProtKB/Swiss-Prot:C0SP94" /translation="MKKTLIILTVLLLSVLTAACSSSSGNQNSKEHKVAVTHDLGKTN VPEHPKRVVVLELGFIDTLLDLGITPVGVADDNKAKQLINKDVLKKIDGYTSVGTRSQ PSMEKIASLKPDLIIADTTRHKKVYDQLKKIAPTIALNNLNADYQDTIDASLTIAKAV GKEKEMEKKLTAHEEKLSETKQKISANSQSVLLIGNTNDTIMARDENFFTSRLLTQVG YRYAISTSGNSDSSNGGDSVNMKMTLEQLLKTDPDVIILMTGKTDDLDADGKRPIEKN VLWKKLKAVKNGHVYHVDRAVWSLRRSVDGANAILDELQKEMPAAKK*" /label="yhfQ CDS" gene 1008302..1009273 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /label="yhfQ gene" downshifts 1009252 /Source="Nicolas_upshifts" /id="D563" /incds=0 /nref=172 /ntot=251 /MaxReadThrough="2.22013" /MaxDrop="5.6726" /score="27.9181244" /energy="-10.9" /TU="NA" /idTUdmin="U833" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1009305..1009886) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10869096, 11827481, 12870714, 17693564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869096, 11827481, 12870714, 17693564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase; putative (phosphoglycerate) mutase" /protein_id="NP_388915.1" /db_xref="EnsemblGenomes-Gn:BSU10340" /db_xref="EnsemblGenomes-Tr:CAB12874" /db_xref="GOA:O07617" /db_xref="InterPro:IPR001345" /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="SubtiList:BG13062" /db_xref="UniProtKB/Swiss-Prot:O07617" /translation="MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVK DFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPD NIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQST RLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK*" /label="phoE CDS" gene complement(1009305..1009886) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /label="phoE gene" downshifts complement(1009328) /Source="Nicolas_upshifts" /id="D564" /incds=0 /nref=218 /ntot=256 /MaxReadThrough="1.23197" /MaxDrop="6.359" /score="28.9228703" /energy="-10.9" /TU="NA" /idTUdmin="U834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1009910..1009929) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1009922) /Source="Nicolas_upshifts" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1009945..1009948) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1009957..1011051) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /EC_number="2.3.1.9" /experiment="publication(s) with functional evidences, PMID:12368242, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acetyltransferase" /protein_id="NP_388916.1" /db_xref="EnsemblGenomes-Gn:BSU10350" /db_xref="EnsemblGenomes-Tr:CAB12875" /db_xref="GOA:O07618" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG13063" /db_xref="UniProtKB/Swiss-Prot:O07618" /translation="MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQV DEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGT MYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQ RSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSG IADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVT PDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYE AKRRPDCQYAVAAIGSGGGIGLALLFEVLA*" /label="yhfS CDS" gene complement(1009957..1011051) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /label="yhfS gene" CDS complement(1011048..1012487) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12368242, 28032445, 28414710; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative long-chain fatty-acid-CoA ligase (proofreading for biotin synthesis)" /protein_id="NP_388917.1" /db_xref="EnsemblGenomes-Gn:BSU10360" /db_xref="EnsemblGenomes-Tr:CAB12876" /db_xref="GOA:O07619" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13064" /db_xref="UniProtKB/Swiss-Prot:O07619" /translation="MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLR SQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVV TLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAF TRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFS PAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAW PHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGK IFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEI ERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWV FADSLPETSSGKIARSRVKKWLEESVQYK*" /label="yhfT CDS" gene complement(1011048..1012487) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /label="yhfT gene" CDS complement(1012494..1013054) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12368242, 15849754, 16850406, 18931129, 23709504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="biotin transporter" /protein_id="NP_388918.1" /db_xref="EnsemblGenomes-Gn:BSU10370" /db_xref="EnsemblGenomes-Tr:CAB12877" /db_xref="GOA:O07620" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13065" /db_xref="UniProtKB/Swiss-Prot:O07620" /translation="MLKLIDMMHIAIFTALMAVLGFMPPLFLSFTPVPITLQTLGVML AGSILRPKSAFLSQLVFLLLVAFGAPLLPGGRGGFGVFFGPSAGFLIAYPLASWLISL AANRLRKVTVLRLFFTHIVFGIIFIYLLGIPVQAFIMHIDLSQAAFMSLAYVPGDLIK AAVSAFLAIKITQALSLSDTMFTKGG*" /label="bioY CDS" gene complement(1012494..1013054) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /label="bioY gene" misc_feature complement(1012504..1012523) /Source="Nicolas_upshift_promotors" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1012518) /Source="Nicolas_upshifts" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1013079..1013098) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1013093) /Source="Nicolas_upshifts" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1013113..1013120) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1013189..1014487) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="heme-based dioxygen sensor" /protein_id="NP_388919.1" /db_xref="EnsemblGenomes-Gn:BSU10380" /db_xref="EnsemblGenomes-Tr:CAB12878" /db_xref="GOA:O07621" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR009050" /db_xref="PDB:1OR4" /db_xref="PDB:1OR6" /db_xref="SubtiList:BG13066" /db_xref="UniProtKB/Swiss-Prot:O07621" /translation="MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLG DAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQE MFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLK AIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSR SVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEM VKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSED TKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISK EQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE*" /label="hemAT CDS" gene complement(1013189..1014487) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /label="hemAT gene" downshifts complement(1013200) /Source="Nicolas_upshifts" /id="D565" /incds=0 /nref=209 /ntot=243 /MaxReadThrough="2.70691" /MaxDrop="6.97357" /score="5.86442746" /energy="-6.9" /TU="NA" /idTUdmin="U837" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1014541..1014559) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1014544) /Source="Nicolas_upshifts" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1014573..1014579) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1014626..1016155) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with Rieske [2Fe-2S] center" /protein_id="NP_388920.1" /db_xref="EnsemblGenomes-Gn:BSU10390" /db_xref="EnsemblGenomes-Tr:CAB12879" /db_xref="GOA:O07622" /db_xref="InterPro:IPR005805" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG13067" /db_xref="UniProtKB/Swiss-Prot:O07622" /translation="MANQHFAKEAPETYWKTSTDLPSFPALQEDTECDVTIIGGGITG ITTAYELTKRGFRVVLIEANQVLNGTTAHTTAKVTAQHDMIYDEFIRHFGLNHARLYY EANQNAIDYIKGIVDEHQIDCEWIEQDAYLYTANENAVQKIHTEHEAYTKLGIERDLI KDLPIPLGSKLALVMKNQAQFHPLQYLKALLEQIVQKGGRIYEETVALDIKKGERPEV VTKSRHAIKSRFIICCSHFPFYDGGGLYAARMYSDRSYVLAIKPKIEYPEGMYLSIDQ PSVALRYTVVNGEKLILFSGVSHKTGQGKAMSTHYETLRQLAESTIGIESIPYYWSTQ DLVTIDKIPFIGPMSENEDNILVATGFKKWGMTSSAVAATLLSDLVEKKENPYESIFT PSRFHLNPGLQKVISYNADVAKHLIKGKLEKPDVQFEDISPGEGKAVTINGRRAGAFR DETGCLHLVDTTCTHLGCEVEWNDSEHTWDCPCHGSRFKPSGEVVEGPAIKPLKQIDL D*" /label="yhfW CDS" gene complement(1014626..1016155) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /label="yhfW gene" promotor_-10 complement(1016182..1016200) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1016192) /Source="Nicolas_upshifts" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1016211..1016216 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1016215..1016220) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1016228 /Source="Nicolas_upshifts" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1016232..1016250 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1016267..1017124 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18643936, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388921.1" /db_xref="EnsemblGenomes-Gn:BSU10400" /db_xref="EnsemblGenomes-Tr:CAB12880" /db_xref="GOA:P40397" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11058" /db_xref="UniProtKB/Swiss-Prot:P40397" /translation="MANQKKKTLPPQHQNQQPGFEYLMDPRPVFDKPKKAKKLEGKTA IITGGDSGIGRAVSVLFAKEGANVVIVYLNEHQDAEETKQYVEKEGVKCLLIAGDVGD EAFCNDVVGQASQVFPSIDILVNNAAEQHVQPSIEKITSHQLIRTFQTNIFSMFYLTK AVLPHLKKGSSIINTASITAYKGNKTLIDYSATKGAIVTFTRSLSQSLVQQGIRVNAV APGPIWTPLIPASFAAKDVEVFGSDVPMERPGQPVEVAPSYLYLASDDSTYVTGQTIH VNGGTIVNG*" /label="yhxC CDS" gene 1016267..1017124 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /label="yhxC gene" downshifts 1017106 /Source="Nicolas_upshifts" /id="D566" /incds=0 /nref=10 /ntot=36 /MaxReadThrough="2.65833" /MaxDrop="4.80135" /score="-8.69335909" /energy="-4.5" /TU="NA" /idTUdmin="U839" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1017152..1017385) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388922.1" /db_xref="EnsemblGenomes-Gn:BSU10410" /db_xref="EnsemblGenomes-Tr:CAB12881" /db_xref="InterPro:IPR014957" /db_xref="SubtiList:BG13087" /db_xref="UniProtKB/Swiss-Prot:O31594" /translation="MKEKKSYTELMKSRNTQKTKEFDVTMTDIYIQMVLDESLYNRRL AMLTDQINKALDEKDKDAFLTLSKEYAALKQSE*" /label="yhzC CDS" gene complement(1017152..1017385) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /label="yhzC gene" downshifts complement(1017185) /Source="Nicolas_upshifts" /id="D567" /incds=0 /nref=191 /ntot=247 /MaxReadThrough="3.34616" /MaxDrop="7.00218" /score="21.4902337" /energy="-12.3" /TU="U841" /idTUdmin="U844" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1017402..1017421) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1017405..1017406 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1017405 /Source="Nicolas_upshifts" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1017409..1017424 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1017424) /Source="Nicolas_upshifts" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1017426..1018281) /Source="Nicolas_S_feature" /locus_tag="new_1116857_1117712_c" /HighExp="Salt, Etha, C30, Heat, S8, LPhT, Gly, C90, S7, UNK1" /AntisenseName="comK" /AntisenseCor="-5.68778941053006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S365" promotor_-35 complement(1017436..1017443) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1017608..1017615 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-35" promotor_-10 1017627..1017646 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-10" upshifts 1017633 /Source="Nicolas_upshifts" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="upshifts" CDS 1017678..1018256 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" /label="comK CDS" gene 1017678..1018256 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /label="comK gene" S_feature 1018257..1018402 /Source="Nicolas_S_feature" /locus_tag="new_1117688_1117833" /HighExp="GM 150, C30, T-4.40H, T-3.40H, GM 120, M9-tran, T-2.40H, C90, G/S, T-1.10H" /AntisenseName="yhxD" /AntisenseCor="-0.229484184862048" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S366" CDS complement(1018303..1019202) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388924.1" /db_xref="EnsemblGenomes-Gn:BSU10430" /db_xref="EnsemblGenomes-Tr:CAB12883" /db_xref="GOA:P40398" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11060" /db_xref="UniProtKB/Swiss-Prot:P40398" /translation="MSDSNLTNPIKAFFHDEFPEQYQEPPGLQKNMKPVPDCGEKSYK GSGKLTGRKALVTGGDSGIGRAAAIAYAREGADVAINYLPEEQPDAEEVKELIEAEGR KAVLIPGDLSDESFCQDLVKQSHHELGGLDVLALVAGKQQAVENIEDLPTEQIYKTFE VNVFSLYWVVKAALPYLPEGASIITTTSVEGYNPSPMLLDYAATKNAIIGFTVGLGKQ LASKGIRVNSVAPGPIWTPLQISGGQPTENIPKFGQGTPPAPLNRAGQPVELADVYVF LASENSSYVTSQVYGITGGIPTA*" /label="yhxD CDS" gene complement(1018303..1019202) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /label="yhxD gene" downshifts complement(1018326) /Source="Nicolas_upshifts" /id="D568" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="4.95535" /MaxDrop="4.1467" /score="-2.68458203" /energy="-14.6" /TU="U844" /idTUdmin="U844" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1018389..1018392 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1018404 /Source="Nicolas_upshifts" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1018410..1018414 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1018448 /Source="Nicolas_upshifts" /id="D569" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="5.45904" /MaxDrop="5.6543" /score="-8.69335909" /energy="-4.5" /TU="U842" /idTUdmin="U843" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1018493..1019359 /Source="Nicolas_S_feature" /locus_tag="new_1117924_1118790" /HighExp="GM 150, C30, T-4.40H, C90, T-3.40H, T-2.40H, G/S, T-5.40H, M9-tran, nit" /AntisenseName="yhxD" /AntisenseCor="-0.32746434250834699" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S367" promotor_-10 complement(1019229..1019247) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1019246) /Source="Nicolas_upshifts" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1019262..1019268) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1019336..1019343 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1019358..1019377 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1019361 /Source="Nicolas_upshifts" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1019419..1019688 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388925.1" /db_xref="EnsemblGenomes-Gn:BSU10440" /db_xref="EnsemblGenomes-Tr:CAB12884" /db_xref="InterPro:IPR008613" /db_xref="SubtiList:BG13068" /db_xref="UniProtKB/Swiss-Prot:O07555" /translation="MKKAAAVLLSLGLVFGFSYGAGHVAEAKTKVKVYKNCKELNKVY KGGVARTSKVKNKGGKTKYKPYVSKALYDANKNKDRDKDLIACER*" /label="yhjA CDS" gene 1019419..1019688 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /label="yhjA gene" downshifts 1019680 /Source="Nicolas_upshifts" /id="D570" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.67325" /MaxDrop="7.59695" /score="27.4895724" /energy="-11.2" /TU="NA" /idTUdmin="U845" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1019728) /Source="Nicolas_upshifts" /id="D571" /incds=0 /nref=11 /ntot=113 /MaxReadThrough="2.40747" /MaxDrop="4.60953" /score="20.2036192" /energy="-11.2" /TU="NA" /idTUdmin="U846" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1019731..1021200) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite cotransporter" /protein_id="NP_388926.1" /db_xref="EnsemblGenomes-Gn:BSU10450" /db_xref="EnsemblGenomes-Tr:CAB12885" /db_xref="GOA:O07556" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13069" /db_xref="UniProtKB/Swiss-Prot:O07556" /translation="MNAALIIIFGVLLLSIFLGIRAQKGKDMNLEQWTVGGRGFGTVF VFLLMAGEIYTTFTFLGGSGWAYGKGGPAFYIIAYGCLAYILSYWLLPAVWTYAKQHK LMSQSDFFTKKYNSPLLGILVSLVGIAALIPYLVLQLKGLGLIVSETSYGKITPTAAI WIGAVSITVYVMVSGIHGSAWISVVKDIMILVVVLFLGVYLPIHYYGGFQDMFQQIET AKPGFLTLPESGQSVAWFSSTVLLTALGFYMWPHTFSASYSAENPKVFRKNAIIMPLY QLVLLFVLFVGFAAILQVPDLNGADGDLSLLRLSLQAFDPWFVGIIGAAGLLTALVPG SMILMSASTLFAKNVYKVIAPRTTEQQVSALAKFLVPVIALISVYFTFKGGNTIVTLL LMGYSLVTQLFPALLFSLLKHNMVTKQGAFAGIIAGVGAVTYITMTETTIGTLFPALP QAAKDLNVGIVALLLNITVMMAVSLMTRKAKSAAADQAA*" /label="yhjB CDS" gene complement(1019731..1021200) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /label="yhjB gene" CDS complement(1021197..1021397) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388927.1" /db_xref="EnsemblGenomes-Gn:BSU10460" /db_xref="EnsemblGenomes-Tr:CAB12886" /db_xref="GOA:O07557" /db_xref="InterPro:IPR021741" /db_xref="SubtiList:BG13070" /db_xref="UniProtKB/Swiss-Prot:O07557" /translation="MKLIHVLAALPFIGILLGIPFANKVTPYVFGMPFILAYIVMWAL LTSALMAIVYVLDKENKKEEAE*" /label="yhjC CDS" gene complement(1021197..1021397) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /label="yhjC gene" S_feature complement(1021398..1021516) /Source="Nicolas_S_feature" /locus_tag="new_1120829_1120947_c" /HighExp="S1, Etha, HiOs, MG 120, LoTm, T-5.40H, S2, GM-0.1, GM-0.2, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S368" promotor_-10 complement(1021499..1021518) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1021516) /Source="Nicolas_upshifts" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1021531..1021538) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1021604) /Source="Nicolas_upshifts" /id="D572" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.99656" /MaxDrop="2.67326" /score="20.2036192" /energy="-11.2" /TU="U848" /idTUdmin="U848" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(1021605..1021967) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388928.1" /db_xref="EnsemblGenomes-Gn:BSU10470" /db_xref="EnsemblGenomes-Tr:CAB12887" /db_xref="GOA:O07558" /db_xref="SubtiList:BG13071" /db_xref="UniProtKB/Swiss-Prot:O07558" /translation="MPNLQEEIYDLIERALFLPMAITIFNRDLAGIEESTLKLKHPYK QLISESLKIAQKDLMEVRKELRKRKIAIRETERDEAFTLYTFVIDGYEENHRYFNPRI REQVSELLTYYLFAPDRL*" /label="yhjD CDS" gene complement(1021605..1021967) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /label="yhjD gene" promotor_-35 1021805..1021810 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1021826..1021844 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1021827 /Source="Nicolas_upshifts" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1021836..1022075 /Source="Nicolas_S_feature" /locus_tag="new_1121267_1121506" /HighExp="S6, S4, S8, S5, LoTm, B36, S3, S7, BT, B60" /AntisenseName="yhjD" /AntisenseCor="0.24202608585419999" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S369" promotor_-10 complement(1021997..1022016) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1022015) /Source="Nicolas_upshifts" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1022031..1022038) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1022057..1022064 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1022077 /Source="Nicolas_upshifts" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1022078..1022097 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1022119..1022742 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388929.1" /db_xref="EnsemblGenomes-Gn:BSU10480" /db_xref="EnsemblGenomes-Tr:CAB12888" /db_xref="GOA:O07559" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13072" /db_xref="UniProtKB/Swiss-Prot:O07559" /translation="MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPL IVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLML WVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGY DLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ*" /label="yhjE CDS" gene 1022119..1022742 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /label="yhjE gene" CDS 1022744..1023250 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /EC_number="3.4.21.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9325333, 9694797, 11309398, 12897006, 14568161, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 9694797, 11309398, 12897006, 14568161, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388930.1" /db_xref="EnsemblGenomes-Gn:BSU10490" /db_xref="EnsemblGenomes-Tr:CAB12889" /db_xref="GOA:O07560" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG12674" /db_xref="UniProtKB/Swiss-Prot:O07560" /translation="MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNE LLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEP FLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI VGVISDAE*" /label="sipV CDS" gene 1022744..1023250 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /label="sipV gene" downshifts 1023243 /Source="Nicolas_upshifts" /id="D573" /incds=0 /nref=131 /ntot=250 /MaxReadThrough="0.63331" /MaxDrop="4.58282" /score="-7.37718733" /energy="-7.1" /TU="NA" /idTUdmin="U847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1023301..1023308 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1023322..1023341 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1023331..1023430 /Source="Nicolas_S_feature" /locus_tag="new_1122762_1122861" /HighExp="LBGstat, LBGexp, Lbtran, C90, dia0, Lbexp, HPh, dia5, aero, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S370" upshifts 1023331 /Source="Nicolas_upshifts" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="upshifts" CDS 1023431..1024930 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7678243, 15121720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic compound monooxygenase/hydroxylase" /protein_id="NP_388931.1" /db_xref="EnsemblGenomes-Gn:BSU10500" /db_xref="EnsemblGenomes-Tr:CAB12890" /db_xref="GOA:O07561" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13073" /db_xref="UniProtKB/Swiss-Prot:O07561" /translation="MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSK ALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQS KTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGA GSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRV VVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGR IFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAE GLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPP NRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLA EPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV*" /label="yhjG CDS" gene 1023431..1024930 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /label="yhjG gene" promotor_-35 1024938..1024945 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1024957 /Source="Nicolas_upshifts" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1024959..1024978 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1025007..1025534 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388932.1" /db_xref="EnsemblGenomes-Gn:BSU10510" /db_xref="EnsemblGenomes-Tr:CAB12891" /db_xref="GOA:Q796S4" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13074" /db_xref="UniProtKB/Swiss-Prot:Q796S4" /translation="MNTDHTKRNLFELYAELIHQQEKWEGLIKAFLSDELRKLDVEHG SKSQLTMTEIHVLSCVGDNEPINVTSIAEKMNTTKATVSRISTKLLGAGFLHRTQLSD NKKEVYFRLTPAGKKLHSLHKYYHQKAEQRFLSFFDRYTEEEILFAERLFRDLVTKWY PSSEEIEGGLPSIFK*" /label="yhjH CDS" gene 1025007..1025534 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /label="yhjH gene" downshifts 1025496 /Source="Nicolas_upshifts" /id="D574" /incds=0 /nref=8 /ntot=128 /MaxReadThrough="1.1509" /MaxDrop="3.41655" /score="11.3050978" /energy="-9.9" /TU="NA" /idTUdmin="U851" /TUdmin=8 /isTUend="TRUE" /label="downshifts" S_feature complement(1025548..>1025568) /Source="Nicolas_S_feature" /locus_tag="new_1124979_1125122_c" /HighExp="B36, B60, T0.30H, LBGstat, T1.30H, T1.0H, LPhT, LBGtran, Diami, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S371" SCAR join(1025568,1025584) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" N_region 1025569..1025583 /note="inserted sequence possibly derived from two restrictions with NotI and SacI" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" S_feature <1025584..1025870 /Source="Nicolas_S_feature" /locus_tag="new_1130705_1131082" /HighExp="T4.0H, T5.0H, T3.30H, T2.0H, HiOs, T2.30H, T3.0H, LoTm, T1.30H, Pyr" /AntisenseName="yhjN" /AntisenseCor="-5.0383887616073E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig="0.997" /label="S375" S_feature complement(<1025584..1025705) /Source="Nicolas_S_feature" /locus_tag="new_1130759_1130917_c" /HighExp="B60, Sw, Cold, B36, BI, GM 15, GM 10, C30, GM 25, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S376" downshifts complement(1025590) /Source="Nicolas_upshifts" /id="D577" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="3.07371" /MaxDrop="4.24831" /score="-1.9470655" /energy="-7.1" /TU="U856" /idTUdmin="U856" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1025706..1026860) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (recentHGT island)" /protein_id="NP_388938.1" /db_xref="EnsemblGenomes-Gn:BSU10570" /db_xref="EnsemblGenomes-Tr:CAB12897" /db_xref="GOA:O07568" /db_xref="InterPro:IPR007820" /db_xref="InterPro:IPR017516" /db_xref="SubtiList:BG13080" /db_xref="UniProtKB/Swiss-Prot:O07568" /translation="MKKDENLLKDLWFIAISAAGGFILSLTGISIGWMIGTLIVACCL AMIRPAWLMMAPDQKGINRRWLALGQMILGIELGQKLNLSVLSVLKDHWFSVGVMLIL SILLAMLSGYVLWRFSKTDMMTSFVGTAPGGLSAMPSIAQEVGANTAIVSLVQMMRVL LVVLSIPFLVILIYTKQDRTASAAAETISSATTDFRLAPVLWTVILILAAWGACKAAK FLKFPAPWLLGSMLGVAIVHVGGAAVTGHDMTAWWLSQANHVSQVFLGATIGSKMYKS MFAGVTRIIIVGFVSSVGLIAAMFLSAVIVSELTGISLITSVLAFAPGGIAEMATTSV TLHADSTFVVAVQVIRVILVIALLPPFYRLLHHLHGEKKDKKSSISGSSA*" /label="yhjN CDS" gene complement(1025706..1026860) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /label="yhjN gene" S_feature complement(1026861..1026932) /Source="Nicolas_S_feature" /locus_tag="new_1132073_1132144_c" /HighExp="Cold, GM 15, GM 10, dia15, BC, BI, Salt, B60, Sw, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S377" promotor_-10 complement(1026915..1026934) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1026931) /Source="Nicolas_upshifts" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1026948..1026953) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1026967..1028172) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease (recent HGT island)" /protein_id="NP_388939.1" /db_xref="EnsemblGenomes-Gn:BSU10580" /db_xref="EnsemblGenomes-Tr:CAB12898" /db_xref="GOA:O07569" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13081" /db_xref="UniProtKB/Swiss-Prot:O07569" /translation="MLTSFHSIKSRYTAPVRLRFFGELLTSLTGAMMGPFMVLYLHEQ LNGSIMMPMLIISLQPFADIFLTLAAGRVTDRLGRRTAILTALLLQSAAMTGFVFAEH AYVFAILYVMNGIGRSLYIPASRAQIAESTPESRRSEVFAVINAIYSTGLTAGPLVGM LLYNHNPVWIFALDAAALFIYFLIAALKLPETKPLHPAVTPKMSASFTIYRPVLLLLL LSLPISMLYAQTETTYRLFSKNMFSDYLSMLTIYSAAKALFSCVLQVPLVKGTEKLSM KTILFITYICYSLAAAGFACSTSLTMLLVTAAVMTVGESIGLTHIQTFISKLAPPHLL GRFYAVYGLHWDISRSIGPLAGGLILTSFGGEVIFYALAVCLLTAGLSLTYTIEKLEH KVIRKVNRL*" /label="yhjO CDS" gene complement(1026967..1028172) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /label="yhjO gene" misc_feature 1028193..1028212 /Source="Nicolas_upshift_promotors" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1028198 /Source="Nicolas_upshifts" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1028286..1030013 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcription factor" /protein_id="NP_388940.1" /db_xref="EnsemblGenomes-Gn:BSU10590" /db_xref="EnsemblGenomes-Tr:CAB12899" /db_xref="GOA:O07570" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR025370" /db_xref="InterPro:IPR030678" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13082" /db_xref="UniProtKB/Swiss-Prot:O07570" /translation="MKLIEHYVALVKTGCAEYGQMNEMTLTEIADCLFCTERNAKLIL HKLENSNWIIRESGAGRGRKSKIAFLRRPEELLLQTAKEYTMSGKLKKAKELLQQYQS AFPGLQNEYNMWLSEVFGFVTETGENGAKDVLRLFITPESVSSLDPCQIFLRSEGHFV KQIFDTLFTFDSDMQEPKPHLVHGWEEVGKKQWRFFLRKGVLFHNGQPLTSRDVAFTF QRFLELADNPYKWLLHGVKQVLEKGPYCVELILDKPNALLPYALCDERLSILPAEQGG GKNGTGPFQMNQQHSGMLVLEANERYFKGRPYLDRVEFVFSEQAGEMNGFTIQEKQTC PEQQTVFDERHVQYLSLNLKKKGPLQHRSFRKALRLLISSERLVREAGGHRRIPVTSF LHPSPFEWEGVSPSELLKKSGYEGETIVLYTFSETDHREDAEWIQNICAQHGIRLTLQ FCDAADLRRPEIVQMADIIHDSATFYQDSEFGFLHLLLSENSFLYQHLSEKLTQICSG MTERMFSMPDRCSRINILRDIDRQMIQELNAIPLYQNVLQVTSSKNVKGLVLDEEGWI DLYSVWLSK*" /label="yhjP CDS" gene 1028286..1030013 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /label="yhjP gene" promotor_-35 1029599..1029606 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1029621..1029640 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1029628 /Source="Nicolas_upshifts" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1030043..1030369) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12625841; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative metal-chelating cysteine-rich protein of unknown function" /protein_id="NP_388941.1" /db_xref="EnsemblGenomes-Gn:BSU10600" /db_xref="EnsemblGenomes-Tr:CAB12900" /db_xref="InterPro:IPR005560" /db_xref="PDB:5FIG" /db_xref="SubtiList:BG13083" /db_xref="UniProtKB/Swiss-Prot:O07571" /translation="MEQYSEACIEACIDCMKACNHCFTKCLEESVQHHLSGCIRLDRE CADICALAVKAMQTDSPFMKEICALCADICEACGTECGKHDHDHCQACAKACFTCAEQ CRSMAA*" /label="yhjQ CDS" gene complement(1030043..1030369) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /label="yhjQ gene" CDS complement(1030487..1030924) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22078549, 22882546; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative electron carrier protein (putative sporulation gene)" /protein_id="NP_388942.1" /db_xref="EnsemblGenomes-Gn:BSU10610" /db_xref="EnsemblGenomes-Tr:CAB12901" /db_xref="GOA:O07572" /db_xref="InterPro:IPR003251" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13084" /db_xref="UniProtKB/Swiss-Prot:O07572" /translation="MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAH SDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQ ETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER*" /label="yhjR CDS" gene complement(1030487..1030924) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /label="yhjR gene" downshifts complement(1030496) /Source="Nicolas_upshifts" /id="D578" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.72767" /MaxDrop="3.86885" /score="16.2430017" /energy="-11.5" /TU="U859" /idTUdmin="U859" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1030955..1030974) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1030975) /Source="Nicolas_upshifts" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1030987..1030996) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1031044..1031051 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1031065..1031084 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1031077 /Source="Nicolas_upshifts" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="upshifts" CDS 1031108..1034608 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit B)" /protein_id="NP_388943.2" /db_xref="EnsemblGenomes-Gn:BSU10620" /db_xref="EnsemblGenomes-Tr:CAB12902" /db_xref="GOA:P23477" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014140" /db_xref="InterPro:IPR027417" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10465" /db_xref="UniProtKB/Swiss-Prot:P23477" /translation="MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMT FLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEE HKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSE KLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEF RVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYK ELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHAL VREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLD VLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQ YRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRY LEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQ QMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVL SDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPS MIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDIS DVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETF NACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQC ELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGL ELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLA EVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQE IFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLL TKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKA EKDKTILEWIKKEADGNEHS*" /label="addB CDS" gene 1031108..1034608 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /label="addB gene" CDS 1034595..1038293 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit A)" /protein_id="NP_388944.2" /db_xref="EnsemblGenomes-Gn:BSU10630" /db_xref="EnsemblGenomes-Tr:CAB12903" /db_xref="GOA:P23478" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014152" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10466" /db_xref="UniProtKB/Swiss-Prot:P23478" /translation="MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERM IRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLN RASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKA FFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPF YQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSE LYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKS LAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSE AARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAE PLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQ AELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSP FKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVA VALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGD RSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANL RVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKG LEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMR RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQAR TYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKS ERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYS GRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHR LYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAH EADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLY TKAVEQIAKTKVKGCALYFFDGGHILTL*" /label="addA CDS" gene 1034595..1038293 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /label="addA gene" S_feature 1038294..1038364 /Source="Nicolas_S_feature" /locus_tag="new_1143506_1143576" /HighExp="H2O2, C90, Heat, LBGtran, dia15, HiTm, Diami, C30, Lbtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S378" CDS 1038365..1039540 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7968921, 8493111, 16780573" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7968921, 8493111, 16780573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair exonuclease" /protein_id="NP_388945.3" /db_xref="EnsemblGenomes-Gn:BSU10640" /db_xref="EnsemblGenomes-Tr:CAB12904" /db_xref="GOA:P23479" /db_xref="InterPro:IPR004593" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR026843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG10467" /db_xref="UniProtKB/Swiss-Prot:P23479" /translation="MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIV MAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENG IHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIR QAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVAL GHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGK PLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRP VFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK* " /label="sbcD CDS" gene 1038365..1039540 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /label="sbcD gene" CDS 1039537..1042929 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 19906728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 19906728; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ATP-dependent repair enzyme" /protein_id="NP_388946.2" /db_xref="EnsemblGenomes-Gn:BSU10650" /db_xref="EnsemblGenomes-Tr:CAB12905" /db_xref="GOA:O06714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13088" /db_xref="UniProtKB/Swiss-Prot:O06714" /translation="MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSI LDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEM KVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSL KGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQA EKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSM QKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAW RQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELET VTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEE LNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQ HTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIK RTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYE AFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESII SELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHE AQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDL KLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSI TRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETV AALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVF KGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVS SLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQ SDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM*" /label="sbcC CDS" gene 1039537..1042929 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /label="sbcC gene" promotor_-35 1042184..1042190 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1042205..1042216 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1042212 /Source="Nicolas_upshifts" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1042281..1043254) /Source="Nicolas_S_feature" /locus_tag="new_1147493_1148466_c" /HighExp="S6, S8, S7, BT, C30, B36, S5, C90, Pyr, B60" /AntisenseName="yisB" /AntisenseCor="0.19649597897587401" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S379" CDS 1042943..1043245 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 22984257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 22984257; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="HNH nuclease-like essential for DNA repair" /protein_id="NP_388947.1" /db_xref="EnsemblGenomes-Gn:BSU10660" /db_xref="EnsemblGenomes-Tr:CAB12906" /db_xref="SubtiList:BG13089" /db_xref="UniProtKB/Swiss-Prot:O06715" /translation="MAKQIAGICELCGRSDVQLTEHHLTPKEEGGTFLPTAMLCIPCH KQIHALYTNQELAVRLNGMAELRSDPELARFVKWIRKQPPEKLIKTKKSNERKKKK*" /label="hlpB CDS" gene 1042943..1043245 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /label="hlpB gene" downshifts 1043225 /Source="Nicolas_upshifts" /id="D579" /incds=0 /nref=230 /ntot=269 /MaxReadThrough="1.42126" /MaxDrop="6.71114" /score="0.317490594" /energy="-14.3" /TU="NA" /idTUdmin="U861" /TUdmin=1 /isTUend="TRUE" /label="downshifts" downshifts complement(1043299) /Source="Nicolas_upshifts" /id="D580" /incds=0 /nref=40 /ntot=66 /MaxReadThrough="3.93344" /MaxDrop="5.39228" /score="13.5435041" /energy="-15.3" /TU="U863" /idTUdmin="U863" /TUdmin="-989" /isTUend="FALSE" /label="downshifts" SCAR 1043303..1043304 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27_007" downshifts 1043323 /Source="Nicolas_upshifts" /id="D586" /incds=0 /nref=239 /ntot=267 /MaxReadThrough="1.55031" /MaxDrop="8.31576" /score="36.3638154" /energy="-12.3" /TU="NA" /idTUdmin="U868" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1043362..1043949) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388959.1" /db_xref="EnsemblGenomes-Gn:BSU10780" /db_xref="EnsemblGenomes-Tr:CAB12918" /db_xref="InterPro:IPR024488" /db_xref="SubtiList:BG12239" /db_xref="UniProtKB/Swiss-Prot:O06727" /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDIL LADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALL DSLDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQ HHYNYSSEGTGDRFEWTASNGKRSIMYTAVQRGRK*" /label="yisN CDS" gene complement(1043362..1043949) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /label="yisN gene" promotor_-10 complement(1043964..1043983) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1043983) /Source="Nicolas_upshifts" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1043999..1044001) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1044004..1044010 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1044022 /Source="Nicolas_upshifts" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1044025..1044043 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1044028..1044094 /Source="Nicolas_S_feature" /locus_tag="new_1157170_1157236" /HighExp="S6, S5, S7, S8, B36, S4, BT, G/S, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S387" CDS 1044095..1045939 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /EC_number="6.3.5.4" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (sporulation related)" /protein_id="NP_388960.2" /db_xref="EnsemblGenomes-Gn:BSU10790" /db_xref="EnsemblGenomes-Tr:CAB12919" /db_xref="GOA:O05272" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG12240" /db_xref="UniProtKB/Swiss-Prot:O05272" /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHV LFGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSD TEVLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLF GSEIKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGL NIWRYWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAI AAGHFEKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTEAFGTTHHKCVIS QKDLVDHLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFH TADVESGFPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKA RRQLFYLNMLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNRE KGILRKALEGILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRK QLDQLLETEGSSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER*" /label="asnO CDS" gene 1044095..1045939 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /label="asnO gene" S_feature 1045940..1046007 /Source="Nicolas_S_feature" /locus_tag="new_1159082_1159149" /HighExp="S6, S5, S7, B36, BT, S8, S4, B60, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S388" downshifts 1045964 /Source="Nicolas_upshifts" /id="D587" /incds=0 /nref=12 /ntot=43 /MaxReadThrough="3.29969" /MaxDrop="4.67478" /score="3.55879494" /energy="-14.8" /TU="U870" /idTUdmin="U870" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1046069..1046548) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation related)" /protein_id="YP_054576.1" /db_xref="EnsemblGenomes-Gn:BSU10800" /db_xref="EnsemblGenomes-Tr:CAE01451" /db_xref="GOA:Q7WY73" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:2QE9" /db_xref="SubtiList:BG14187" /db_xref="UniProtKB/Swiss-Prot:Q7WY73" /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFH IIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELV SVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY* " /label="yizA CDS" gene complement(1046069..1046548) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /label="yizA gene" upshifts complement(1046568) /Source="Nicolas_upshifts" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1046572..1046590) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1046601..1046609) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1046740..1046744 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1046757 /Source="Nicolas_upshifts" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1046759..1046778 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1046780..1047604 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /EC_number="3.6.1.27" /experiment="publication(s) with functional evidences, PMID:23295493, 25308276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23295493, 25308276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate phosphatase" /protein_id="NP_388961.1" /db_xref="EnsemblGenomes-Gn:BSU10810" /db_xref="EnsemblGenomes-Tr:CAB12920" /db_xref="GOA:O06728" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="PDB:3WE9" /db_xref="SubtiList:BG12241" /db_xref="UniProtKB/Swiss-Prot:O06728" /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQAS WAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFR EFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQ LVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEE CQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI*" /label="farP CDS" gene 1046780..1047604 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /label="farP gene" promotor_-35 1046992..1046998 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1047013..1047031 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1047020 /Source="Nicolas_upshifts" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1047614..1049064 /Source="Nicolas_S_feature" /locus_tag="new_1160756_1162206" /HighExp="Salt, Etha, Sw, Cold, G150, G180, G135, LBGtran, Heat, Paraq" /AntisenseName="yisQ" /AntisenseCor="0.19511630802652" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S389" CDS complement(1047634..1049001) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na(+)-driven efflux transporter" /protein_id="NP_388962.1" /db_xref="EnsemblGenomes-Gn:BSU10820" /db_xref="EnsemblGenomes-Tr:CAB12921" /db_xref="GOA:O07940" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG12242" /db_xref="UniProtKB/Swiss-Prot:O07940" /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTL MLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSI GANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAI LKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAM IVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGA QALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIA AATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDA KFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWI QKGMA*" /label="yisQ CDS" gene complement(1047634..1049001) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /label="yisQ gene" promotor_-35 1049033..1049040 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1049054..1049073 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1049066 /Source="Nicolas_upshifts" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="upshifts" CDS 1049125..1049988 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388963.1" /db_xref="EnsemblGenomes-Gn:BSU10830" /db_xref="EnsemblGenomes-Tr:CAB12922" /db_xref="GOA:P40331" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11064" /db_xref="UniProtKB/Swiss-Prot:P40331" /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQG TLYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSN WSELQQEKGSFEELARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILF EELMLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQ QVLGVTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPI EYRKIVSRKVQ*" /label="yisR CDS" gene 1049125..1049988 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /label="yisR gene" CDS 1050006..1051019 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8407808, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8407808, 23504016, 28693424; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of iolX (LacI family)" /protein_id="NP_388964.1" /db_xref="EnsemblGenomes-Gn:BSU10840" /db_xref="EnsemblGenomes-Tr:CAB12923" /db_xref="GOA:P37947" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10847" /db_xref="UniProtKB/Swiss-Prot:P37947" /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEM AYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDP KKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIV VIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLI IQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFD NTILAEMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSP LNT*" /label="iolQ CDS" gene 1050006..1051019 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /label="iolQ gene" downshifts 1051002 /Source="Nicolas_upshifts" /id="D588" /incds=0 /nref=13 /ntot=204 /MaxReadThrough="0.51227" /MaxDrop="3.29173" /score="25.1260914" /energy="-9.6" /TU="NA" /idTUdmin="U874" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-35 1051071..1051078 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1051093..1051112 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1051112..1051227 /Source="Nicolas_S_feature" /locus_tag="new_1164254_1164369" /HighExp="Lbstat, M40t90, M0t90, BI, G150, dia0, Mt0, Lbexp, Lbtran, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S390" upshifts 1051112 /Source="Nicolas_upshifts" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="upshifts" CDS 1051228..1052256 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /EC_number="1.1.1.370" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11160890, 20133360, 23109554, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 20133360, 23109554, 23504016, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NAD(+))" /protein_id="NP_388965.1" /db_xref="EnsemblGenomes-Gn:BSU10850" /db_xref="EnsemblGenomes-Tr:CAB12924" /db_xref="GOA:P40332" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11065" /db_xref="UniProtKB/Swiss-Prot:P40332" /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAE QVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTL SLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGA PPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALT YIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDII PDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLD VKRAYTGM*" /label="iolX CDS" gene 1051228..1052256 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /label="iolX gene" downshifts 1052278 /Source="Nicolas_upshifts" /id="D589" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="0.33001" /MaxDrop="3.45406" /score="8.69111487" /energy="-13.4" /TU="NA" /idTUdmin="U875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1052307..1052816) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25651892; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative enzyme regulator of activity" /protein_id="NP_388966.2" /db_xref="EnsemblGenomes-Gn:BSU10860" /db_xref="EnsemblGenomes-Tr:CAB12925" /db_xref="GOA:O07939" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12243" /db_xref="UniProtKB/Swiss-Prot:O07939" /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDV LLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQ TDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYY LYEKRESKG*" /label="yisT CDS" gene complement(1052307..1052816) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /label="yisT gene" downshifts complement(1052326) /Source="Nicolas_upshifts" /id="D590" /incds=0 /nref=81 /ntot=251 /MaxReadThrough="-0.0416600000000003" /MaxDrop="7.15629" /score="27.2292301" /energy="-13.4" /TU="NA" /idTUdmin="U876" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1052829..1052847) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1052845) /Source="Nicolas_upshifts" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1052859..1052867) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1052866..1053528) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid related metabolite efflux transporter" /protein_id="NP_388967.1" /db_xref="EnsemblGenomes-Gn:BSU10870" /db_xref="EnsemblGenomes-Tr:CAB12926" /db_xref="GOA:O06730" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG13100" /db_xref="UniProtKB/Swiss-Prot:O06730" /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQ QGALQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYM GWVTWNIRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEK WLFMAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLF CN*" /label="yisU CDS" gene complement(1052866..1053528) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /label="yisU gene" promotor_-35 1053547..1053553 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1053567..1053586 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1053576 /Source="Nicolas_upshifts" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="upshifts" CDS 1053595..1055049 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 19383706; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388968.2" /db_xref="EnsemblGenomes-Gn:BSU10880" /db_xref="EnsemblGenomes-Tr:CAB12927" /db_xref="GOA:Q796Q6" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13101" /db_xref="UniProtKB/Swiss-Prot:Q796Q6" /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRT LADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSG IHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQP KGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYL QSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQR RKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLR IGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRD AAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGE DRNSIRLSYSYASLGDLETGIKAAAETARRLMMS*" /label="yisV CDS" gene 1053595..1055049 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /label="yisV gene" S_feature complement(1054904..1055056) /Source="Nicolas_S_feature" /locus_tag="new_1168046_1168198_c" /HighExp="Diami, Sw, C90, LBGstat, dia15, Paraq, dia5, BC, M40t45, Oxctl" /AntisenseName="yisV" /AntisenseCor="0.69858995161852" /AntisenseRegPval="-40" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S391" downshifts complement(1054939) /Source="Nicolas_upshifts" /id="D591" /incds=1 /nref=2 /ntot=84 /MaxReadThrough="2.36735" /MaxDrop="2.81041" /score="-5.131548" /energy="-17.3" /TU="NA" /idTUdmin="U879" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1055057..1055695) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388970.1" /db_xref="EnsemblGenomes-Gn:BSU10890" /db_xref="EnsemblGenomes-Tr:CAB12929" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG13103" /db_xref="UniProtKB/Swiss-Prot:O06733" /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGED IERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVG MNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCEL EGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV*" /label="yisX CDS" gene complement(1055057..1055695) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /label="yisX gene" S_feature complement(1055696..1055830) /Source="Nicolas_S_feature" /locus_tag="new_1168838_1168972_c" /HighExp="Diami, dia15, dia5, C90, BC, Paraq, LBGstat, Lbtran, HiOs, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S392" promotor_-35 1055744..1055749 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1055765..1055783 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1055766 /Source="Nicolas_upshifts" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="upshifts" S_feature 1055776..1055900 /Source="Nicolas_S_feature" /locus_tag="new_1168918_1169042" /HighExp="S6, S5, S8, S7, S4, BT, B36, S3, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S393" promotor_-10 complement(1055816..1055835) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1055830) /Source="Nicolas_upshifts" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1055850..1055857) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1055901..1056707 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl hydrolase or peroxidase" /protein_id="NP_388971.1" /db_xref="EnsemblGenomes-Gn:BSU10900" /db_xref="EnsemblGenomes-Tr:CAB12930" /db_xref="GOA:O06734" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13104" /db_xref="UniProtKB/Swiss-Prot:O06734" /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNEL PKRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIA IRYMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADL GKQFFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGR KDRIAPFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS*" /label="yisY CDS" gene 1055901..1056707 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /label="yisY gene" downshifts 1056700 /Source="Nicolas_upshifts" /id="D592" /incds=0 /nref=4 /ntot=24 /MaxReadThrough="2.64682" /MaxDrop="5.60718" /score="8.70914085" /energy="-6.5" /TU="NA" /idTUdmin="U878" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1056735..1057334) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /EC_number="2.7.1.25" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenylylsulfate kinase" /protein_id="NP_388972.1" /db_xref="EnsemblGenomes-Gn:BSU10910" /db_xref="EnsemblGenomes-Tr:CAB12931" /db_xref="GOA:O06735" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13105" /db_xref="UniProtKB/Swiss-Prot:O06735" /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLA NAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMI LTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTG IDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII*" /label="yisZ CDS" gene complement(1056735..1057334) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /label="yisZ gene" downshifts complement(1056754) /Source="Nicolas_upshifts" /id="D593" /incds=0 /nref=35 /ntot=44 /MaxReadThrough="1.69999" /MaxDrop="6.8011" /score="17.1506785" /energy="-7.3" /TU="NA" /idTUdmin="U880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1057331..1058500) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /EC_number="2.7.7.4" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfate adenylyltransferase" /protein_id="NP_388973.2" /db_xref="EnsemblGenomes-Gn:BSU10920" /db_xref="EnsemblGenomes-Tr:CAB12932" /db_xref="GOA:O06736" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13106" /db_xref="UniProtKB/Swiss-Prot:O06736" /translation="MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIG GYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGV TYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSF EQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGET KSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTH FIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPH SPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ*" /label="yitA CDS" gene complement(1057331..1058500) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /label="yitA gene" S_feature complement(1058501..1058612) /Source="Nicolas_S_feature" /locus_tag="new_1171643_1171754_c" /HighExp="S6, S7, S8, BT, S5, B36, G/S, Pyr, SMMPr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S394" CDS complement(1058613..1059323) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospho-adenylylsulfate reductase" /protein_id="NP_388974.2" /db_xref="EnsemblGenomes-Gn:BSU10930" /db_xref="EnsemblGenomes-Tr:CAB12933" /db_xref="GOA:O06737" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13107" /db_xref="UniProtKB/Swiss-Prot:O06737" /translation="MNETITYDTWNDMLSKQITDQLIDELDVLKWAYRTYGEKIVYAC SFGAEGMVLLDLISKINKNAHIIFLDTGLHFQETYELIETVKERYPGFAIQMLEPELS LTEQGTKYGGELWKHNPNLCCQLRKIEPLKKHLSGMTAWISGLRRDQSPTRKHIQYVN LDQKFELIKICPLIHWTWDDVWTYIRLHNLPYNKLHDQHYPSIGCEMCTLPSPDPNDE RAGRWAGREKTECGLHQE*" /label="yitB CDS" gene complement(1058613..1059323) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /label="yitB gene" promotor_-10 complement(1059367..1059386) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1059389) /Source="Nicolas_upshifts" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1059399..1059408) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1059438..1059447 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1059461..1059480 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1059472 /Source="Nicolas_upshifts" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="upshifts" CDS 1059508..1060194 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /EC_number="3.1.3.71" /function="15.7: Sporulation and germination" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3346220, 11830598, 15383836, 16341843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho,3-sulfolactate phosphatase (sporulation related)" /protein_id="NP_388975.1" /db_xref="EnsemblGenomes-Gn:BSU10940" /db_xref="EnsemblGenomes-Tr:CAB12934" /db_xref="GOA:O06738" /db_xref="InterPro:IPR005238" /db_xref="InterPro:IPR036702" /db_xref="SubtiList:BG13108" /db_xref="UniProtKB/Swiss-Prot:O06738" /translation="MPIAIYQGHHHSLAPADINIVIDVIRAFTVAHYAFIGGAKEILL VRTADEAFALKDTYPDYVLTGEEKGVGISGFDLDNSPKRMAGQNMTDKSLIQKTTNGV TAALGALNAKHLFVTGFSNAKTTAQHVKKLVANDCVINIVASHPSGDDDMACAEYIKG IIEGTNVVTAAEAIERIKGSSVAEKFFDCRQPLFDSEDIVYCTKELTGDFVMKVKQDG EVPTIERVII*" /label="slpH CDS" gene 1059508..1060194 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /label="slpH gene" CDS 1060191..1060949 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /EC_number="4.4.1.19" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11830598, 15014443, 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho-3-sulfolactate synthase" /protein_id="NP_388976.1" /db_xref="EnsemblGenomes-Gn:BSU10950" /db_xref="EnsemblGenomes-Tr:CAB12935" /db_xref="GOA:O06739" /db_xref="InterPro:IPR003830" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036112" /db_xref="PDB:1U83" /db_xref="SubtiList:BG13109" /db_xref="UniProtKB/Swiss-Prot:O06739" /translation="MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYI DFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGC EYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDM EAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFI QKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL*" /label="slpS CDS" gene 1060191..1060949 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /label="slpS gene" downshifts 1060946 /Source="Nicolas_upshifts" /id="D594" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="2.37654" /MaxDrop="4.17689" /score="-1.32868938" /energy="-17.6" /TU="NA" /idTUdmin="U881" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1060994..1061623) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26335199; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388977.1" /db_xref="EnsemblGenomes-Gn:BSU10960" /db_xref="EnsemblGenomes-Tr:CAB12936" /db_xref="GOA:O06740" /db_xref="InterPro:IPR003740" /db_xref="SubtiList:BG13110" /db_xref="UniProtKB/Swiss-Prot:O06740" /translation="MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAV LLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDI TSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCII FMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK*" /label="yitE CDS" gene complement(1060994..1061623) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /label="yitE gene" promotor_-10 complement(1061657..1061675) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1061674) /Source="Nicolas_upshifts" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1061690..1061695) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1061719..1062834) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 11747447, 27994575; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enolase superfamily enzyme (isomerase /dehydratase)" /protein_id="NP_388978.1" /db_xref="EnsemblGenomes-Gn:BSU10970" /db_xref="EnsemblGenomes-Tr:CAB12937" /db_xref="GOA:O06741" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR036849" /db_xref="PDB:2GDQ" /db_xref="PDB:2GGE" /db_xref="SubtiList:BG13111" /db_xref="UniProtKB/Swiss-Prot:O06741" /translation="MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDG WGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAA KAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIG GTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLP FDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDC LQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDL VSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY*" /label="yitF CDS" gene complement(1061719..1062834) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /label="yitF gene" downshifts complement(1061748) /Source="Nicolas_upshifts" /id="D595" /incds=0 /nref=11 /ntot=42 /MaxReadThrough="1.81817" /MaxDrop="4.27426" /score="13.5713023" /energy="-14.5" /TU="NA" /idTUdmin="U883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1062843..1064111) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 14762009, 15109717, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388979.1" /db_xref="EnsemblGenomes-Gn:BSU10980" /db_xref="EnsemblGenomes-Tr:CAB12938" /db_xref="GOA:Q796Q1" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13112" /db_xref="UniProtKB/Swiss-Prot:Q796Q1" /translation="MESSKQNNGMTIVAIGSIPLILTLGNSMLIPILPKMKSELHLSQ FQVSLVITVFSLIAAFAIPIVGYLADRFSRKVIIIPCLILYGAGGLLAGFAAGFFDNA YPWVMAGRALQGIGAAGTGPIAMALTGDLFKGAQESKVLGLVEASNGMGKVLSPIIGS LIALLVWYGAFFAFPVFCIISIVLTWIFIKEKKKEKEPPPIGQYAKGLLSVFKHEGRW LFTAYLAGATCLFTLFGILFYLSDVLEKTYDTDGVKKGLILAIPLLVMCVTSYTTGSK IGQKQSLMKKLIVLGLAFMTVSYAALSFIENLVLFISVLVLSSIGSGLVLPCVNSFIT GAVGKERRGFVTSLYGSVRFLGVAIGPPIFGRLMQWSRPGMFLSIAGLTLVVGILVMM LIHVKQNNEETKEKEDPKMAGNRLQPAEER*" /label="yitG CDS" gene complement(1062843..1064111) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /label="yitG gene" promotor_-10 complement(1064137..1064148) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1064146) /Source="Nicolas_upshifts" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1064162..1064168) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1064223..1065071) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388980.1" /db_xref="EnsemblGenomes-Gn:BSU10990" /db_xref="EnsemblGenomes-Tr:CAB12939" /db_xref="GOA:O06743" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13113" /db_xref="UniProtKB/Swiss-Prot:O06743" /translation="MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRF FGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIR LCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLA AFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQ IITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYAL ISQALG*" /label="yitH CDS" gene complement(1064223..1065071) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /label="yitH gene" downshifts complement(1064234) /Source="Nicolas_upshifts" /id="D596" /incds=0 /nref=34 /ntot=209 /MaxReadThrough="2.34135" /MaxDrop="3.51892" /score="14.8688564" /energy="-11.7" /TU="NA" /idTUdmin="U884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1065076..1065525) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388981.2" /db_xref="EnsemblGenomes-Gn:BSU11000" /db_xref="EnsemblGenomes-Tr:CAB12940" /db_xref="GOA:O06744" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13114" /db_xref="UniProtKB/Swiss-Prot:O06744" /translation="MLEVKTISVEDTYEIRHRILRPHQSIEQCKYKEDHAEGSFHLGV FYDGTLISIASFSPQSQPLLTEASAYRLRGMATLEGYRDQKAGSTLIKHAEHKLAESG VQAVWCNARHHVKGYYAKLGWKELGEPFDIPGIGNHIVMYKTLRTSR*" /label="yitI CDS" gene complement(1065076..1065525) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /label="yitI gene" promotor_-10 complement(1065546..1065565) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1065560) /Source="Nicolas_upshifts" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1065581..1065582) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1065615..1067453) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /EC_number="1.5.1.20" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 17264075, 20421295, 20951706, 26233166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional homocysteine S-methyltransferase using (R,S)AdoMet and methylenetetrahydrofolate reductase [NAD(P)H]" /protein_id="NP_388982.1" /db_xref="EnsemblGenomes-Gn:BSU11010" /db_xref="EnsemblGenomes-Tr:CAB12941" /db_xref="GOA:O06745" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR029041" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG13115" /db_xref="UniProtKB/Swiss-Prot:O06745" /translation="MGLLEDLQRQVLIGDGAMGTLLYSYGIDRCFEELNISKPEEIQR IHKAYVEAGANIIQTNTYGANYIKLSRHGLEDDIKKMNQEAVKIARASAGDAYVLGTM GGIRTFNKNAYSLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETD LPIMLNVSMHEQGVLQDGTPLSDALRSIADLGADIVGINCRLGPYHMIEALSEVPIFD DVFLSVYPNSSLPSLEEGRLVYETDDTYFQNSASEFRKQGARIIGGCCGTTPNHIRAM AEAVGGLAPITEKEVKTRAKEFISVHHERTEPGLDEIAAKKRSIIVELDPPKKLSFDK FLSAAAELKEAGIDALTLADNSLATPRISNVACGALVKQQLDMRSLVHITCRDRNIIG LQSHLMGLDTLGLNDVLAITGDPSKIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSG KPLGKKTNFSVAAAFNPNVRHLDKAVKRLEKKIDCGADYFVSQPVYSEQQLVDIHNET KHLKTPIYIGIMPLTSSRNAEFIHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIA RSLLDTACELFNGIYLITPFLRSDLTAELTSYIQQKDEQRQNIFLH*" /label="samT CDS" gene complement(1065615..1067453) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /label="samT gene" downshifts complement(1065642) /Source="Nicolas_upshifts" /id="D597" /incds=0 /nref=14 /ntot=91 /MaxReadThrough="3.04289" /MaxDrop="4.13744" /score="12.9586126" /energy="-16.2" /TU="U885" /idTUdmin="U885" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts complement(1067535) /Source="Nicolas_upshifts" /id="D598" /incds=0 /nref=47 /ntot=128 /MaxReadThrough="8.00128" /MaxDrop="5.61487" /score="22.3754155" /energy="-7.3" /TU="U885,U887" /idTUdmin="U887" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1067543..1067660) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswK RNA" gene complement(1067543..1067660) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /label="mswK gene" promotor_-10 complement(1067712..1067731) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" upshifts complement(1067726) /Source="Nicolas_upshifts" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1067746..1067753) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS complement(1067767..1068258) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12943362, 25329577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA or cyclic d-GMP binding protein" /protein_id="NP_388983.1" /db_xref="EnsemblGenomes-Gn:BSU11020" /db_xref="EnsemblGenomes-Tr:CAB12942" /db_xref="InterPro:IPR007551" /db_xref="InterPro:IPR035570" /db_xref="InterPro:IPR035571" /db_xref="InterPro:IPR036183" /db_xref="SubtiList:BG13116" /db_xref="UniProtKB/Swiss-Prot:O06746" /translation="MAKESSFDIVSKVELPEVQNAIQIALKEISTRYDFKGSKSDISL DKEELVLVSDDEFKLSQLKDVLVSKLIKRNVPTKNIDYGKVENASGGTVRQRAKLVQG IDKDNAKKINTIIKNSGLKVKSQVQDDQVRVTGKNKDDLQQIISAVRGADLPIDVQFI NFR*" /label="yitK CDS" gene complement(1067767..1068258) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /label="yitK gene" promotor_-35 1068276..1068279 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1068282..1068301) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" promotor_-10 1068294..1068313 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1068295 /Source="Nicolas_upshifts" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1068300) /Source="Nicolas_upshifts" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1068316..1068323) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS 1068357..1069253 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20399190; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="NP_388984.1" /db_xref="EnsemblGenomes-Gn:BSU11030" /db_xref="EnsemblGenomes-Tr:CAB12943" /db_xref="GOA:O06747" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014464" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13117" /db_xref="UniProtKB/Swiss-Prot:O06747" /translation="MLTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTI LLHNSEMTEDIEDRDEVEVFIYVDQQERLAATMKIPIISADEYGWVEVVDKVEDMGVF VDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPEDIISELFTD ASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKE DGSVNLSLLPRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKR ALGHLMKNGKVYQENGWTYEKK*" /label="yitL CDS" gene 1068357..1069253 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /label="yitL gene" downshifts 1069240 /Source="Nicolas_upshifts" /id="D599" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="1.78082" /MaxDrop="6.73614" /score="40.361011" /energy="-21.5" /TU="NA" /idTUdmin="U886" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1069316) /Source="Nicolas_upshifts" /id="D600" /incds=0 /nref=68 /ntot=158 /MaxReadThrough="1.3386" /MaxDrop="7.40935" /score="10.143892" /energy="-21.5" /TU="NA" /idTUdmin="U888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 1069328..1069329 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_016" S_feature <1069329..1069382 /Source="Nicolas_S_feature" /locus_tag="new_1188125_1188650" /HighExp="G180, Paraq, G135, G150, Oxctl, C30, H2O2, LBGstat, LBGexp, Lbexp" /AntisenseName="yitS" /AntisenseCor="-0.45830528686941202" /AntisenseRegPval="-14.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S395" promotor_-10 complement(<1069329..1069343) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1069347) /Source="Nicolas_upshifts" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1069361..1069366 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1069381..1069399 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1069384 /Source="Nicolas_upshifts" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" CDS 1069421..1070263 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23419162, 23824080; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388993.1" /db_xref="EnsemblGenomes-Gn:BSU11120" /db_xref="EnsemblGenomes-Tr:CAB12952" /db_xref="GOA:P39803" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG10850" /db_xref="UniProtKB/Swiss-Prot:P39803" /translation="MVLDQTKKLLIVIIGALLNAAGLNLFLIPADVYASGFTGVAQLL SSVVDQYAPFYISTGTLLFLLNIPVGILGWLKVGKSFTVYSILSVALTTLFMGILPET SLSHDILLNAVFGGVISAVGIGLTLKYGASTGGLDIVAMVLAKWKDKPVGTYFFILNG IIILTAGLLQGWEKALYTLVTLYVTTRVIDAIHTRHMKLTAMIVTKKADEIKEAIYGK MVRGITTVPAKGAFTNEQKEMMIIVITRYELYDLEKIVKEVDPKAFTNIVQTTGIFGF FRKD*" /label="yitT CDS" gene 1069421..1070263 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /label="yitT gene" promotor_-35 1069916..1069924 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1069935..1069953 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1069935 /Source="Nicolas_upshifts" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="upshifts" S_feature 1070264..1070377 /Source="Nicolas_S_feature" /locus_tag="new_1189532_1189645" /HighExp="Etha, S8, Sw, M9-stat, S7, BC, Gly, S6, Salt, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigB, SigA" /TUshortPSig="0.968, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S396" CDS 1070378..1070737 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8226659, 24555072" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226659, 24555072; Product type f: factor" /codon_start=1 /transl_table=11 /product="intracellular proteinase inhibitor BsuPI" /protein_id="NP_388994.1" /db_xref="EnsemblGenomes-Gn:BSU11130" /db_xref="EnsemblGenomes-Tr:CAB12953" /db_xref="GOA:P39804" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR020481" /db_xref="PDB:3ISY" /db_xref="SubtiList:BG10852" /db_xref="UniProtKB/Swiss-Prot:P39804" /translation="MENQEVVLSIDAIQEPEQIKFNMSLKNQSERAIEFQFSTGQKFE LVVYDSEHKERYRYSKEKMFTQAFQNLTLESGETYDFSDVWKEVPEPGTYEVKVTFKG RAENLKQVQAVQQFEVK*" /label="ipi CDS" gene 1070378..1070737 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /label="ipi gene" downshifts 1070726 /Source="Nicolas_upshifts" /id="D605" /incds=0 /nref=34 /ntot=224 /MaxReadThrough="1.36729" /MaxDrop="5.6855" /score="43.7575824" /energy="-15.6" /TU="NA" /idTUdmin="U893" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1070768..1070965) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; genus orphan" /protein_id="YP_003097702.1" /db_xref="EnsemblGenomes-Gn:BSU11139" /db_xref="EnsemblGenomes-Tr:CAX52590" /db_xref="InterPro:IPR024217" /db_xref="UniProtKB/Swiss-Prot:C0H3Y5" /translation="MRNELFQQAKSFVQQAVMVTNGFEEGDQEQAILRAKNAVSSAYA NSTDAERQQLHQFQNQLDKLQ*" /label="yizC CDS" gene complement(1070768..1070965) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /label="yizC gene" downshifts complement(1070781) /Source="Nicolas_upshifts" /id="D606" /incds=0 /nref=150 /ntot=257 /MaxReadThrough="1.42333" /MaxDrop="8.284" /score="2.35557074" /energy="-17.3" /TU="NA" /idTUdmin="U895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1070966..1071162) /Source="Nicolas_S_feature" /locus_tag="new_1190234_1190430_c" /HighExp="S8, S6, S5, S7, nit, ferm, BT, G/S, Pyr, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99834599999999996" /TUshortSig="SigGF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S397" upshifts complement(1071162) /Source="Nicolas_upshifts" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1071164..1071175) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1071190..1071196) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1071222..1072034) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25012491, 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous)" /protein_id="NP_388995.1" /db_xref="EnsemblGenomes-Gn:BSU11140" /db_xref="EnsemblGenomes-Tr:CAB12954" /db_xref="GOA:P70947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12245" /db_xref="UniProtKB/Swiss-Prot:P70947" /translation="METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCIS TGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISES YNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEED VPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAF GDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL*" /label="ribZC CDS" gene complement(1071222..1072034) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /label="ribZC gene" promotor_-10 complement(1072072..1072091) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1072092..1072099 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1072092) /Source="Nicolas_upshifts" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1072105..1072112) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1072111..1072130 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1072113 /Source="Nicolas_upshifts" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1072155..1072922 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28293230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxylesterase" /protein_id="NP_388996.1" /db_xref="EnsemblGenomes-Gn:BSU11150" /db_xref="EnsemblGenomes-Tr:CAB12955" /db_xref="GOA:P70948" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12246" /db_xref="UniProtKB/Swiss-Prot:P70948" /translation="MIQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNL HIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVLNEIEEIGVLKNHFEKE GLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQIDHIQSQGI EIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKS HYSEQPERLQFIGDENADHKVPRAAVLKTIEWFETYL*" /label="yitV CDS" gene 1072155..1072922 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /label="yitV gene" promotor_-35 1072931..1072937 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1072951 /Source="Nicolas_upshifts" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1072952..1072971 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1072986..1073294 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9209063; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein involved in Fe-S cluster assembly, PaaD-like" /protein_id="NP_388997.1" /db_xref="EnsemblGenomes-Gn:BSU11160" /db_xref="EnsemblGenomes-Tr:CAB12956" /db_xref="InterPro:IPR002744" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG12247" /db_xref="UniProtKB/Swiss-Prot:P70949" /translation="MEEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHI TMTLTSMGCPLAPIIVDEVKKALADLPEVKDTEVHIVWNPPWTRDKMSRYAKIALGIQ *" /label="yitW CDS" gene 1072986..1073294 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /label="yitW gene" downshifts 1073279 /Source="Nicolas_upshifts" /id="D607" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="5.65659" /MaxDrop="4.5598" /score="14.9971829" /energy="-14.7" /TU="U897,U898" /idTUdmin="U897" /TUdmin="-2244" /isTUend="FALSE" /label="downshifts" S_feature 1073324..1073589 /Source="Nicolas_S_feature" /locus_tag="new_1192592_1192857" /HighExp="Etha, dia15, dia5, H2O2, LoTm, Salt, S6, Diami, S8, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S398" CDS 1073590..1075020 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16956367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN/FAD-binding oxidoreductase" /protein_id="NP_388999.3" /db_xref="EnsemblGenomes-Gn:BSU11170" /db_xref="EnsemblGenomes-Tr:CAB12958" /db_xref="GOA:Q796P5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12249" /db_xref="UniProtKB/Swiss-Prot:Q796P5" /translation="MKKKLLAFALCTGAYAALFAYSVNSEQKTATSEMTDVSRLMPVK IKQTVKGQEEEMLIDTVKEANRKNIKISIAGAQHSMGGHTYYEDGIVLDMTGYNKILS LDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGS LIDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTE KMNYSTYSDYFSKHVKGNPDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSE LKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYFLSQNGTEISRNNVMRSESKFLEY ENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKADLSYAKD DMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPK SEAFFQKKRTYDPDERFMNYFYQRYK*" /label="yitY CDS" gene 1073590..1075020 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /label="yitY gene" CDS 1075065..1075559 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transport protein" /protein_id="NP_389000.1" /db_xref="EnsemblGenomes-Gn:BSU11180" /db_xref="EnsemblGenomes-Tr:CAB12959" /db_xref="GOA:P70952" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12250" /db_xref="UniProtKB/Swiss-Prot:P70952" /translation="MFFASSLIFPFYILFVKNIGSSYTQFGFSYGLFGLSGALIYPLL GRLSERFDSRYFLLLNSWGMAVLLLYVPHIGSVVQVYIVQVLLGLFGAMQKHGEKVLI ANFTDSGERGKKIGNYHFWTAVFSAAAIMLGGFLADFFTVQMIFYASSILYFLSGLMM MKTG*" /label="yitZ CDS" gene 1075065..1075559 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /label="yitZ gene" downshifts 1075523 /Source="Nicolas_upshifts" /id="D608" /incds=0 /nref=49 /ntot=208 /MaxReadThrough="1.74762" /MaxDrop="4.22077" /score="34.1294744" /energy="-13.2" /TU="NA" /idTUdmin="U897" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1075697..1075704 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1075703 /Source="Nicolas_upshifts" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1075718..1075737 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1075766..1076803 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /EC_number="1.2.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate gamma-semialdehyde dehydrogenase" /protein_id="NP_389001.2" /db_xref="EnsemblGenomes-Gn:BSU11190" /db_xref="EnsemblGenomes-Tr:CAB12960" /db_xref="GOA:P23715" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR000706" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR023013" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10191" /db_xref="UniProtKB/Swiss-Prot:P23715" /translation="MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEG YPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLR IKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAP LAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQAL NEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRP KGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNE ETGLTITPIYP*" /label="argC CDS" gene 1075766..1076803 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /label="argC gene" CDS 1076823..1078043 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8025667, 10931207, 16409639, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8025667, 10931207, 16409639, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine acetyltransferase; amino-acid acetyltransferase" /protein_id="NP_389002.2" /db_xref="EnsemblGenomes-Gn:BSU11200" /db_xref="EnsemblGenomes-Tr:CAB12961" /db_xref="GOA:P36843" /db_xref="InterPro:IPR002813" /db_xref="InterPro:IPR016117" /db_xref="SubtiList:BG10192" /db_xref="UniProtKB/Swiss-Prot:P36843" /translation="MIQLSEDQIVKVTGDVSSPKGFQAKGVHCGLRYSKKDLGVIISE TPAVSAAVYTQSHFQAAPIKVTQDSLKHGPTLKAVIVNSAIANACTGEQGLKDAYTMR ESFASQLGIEPELVAVSSTGVIGEHLDMEKIHAGIELLKETPAGSGDFEEAILTTDTV IKQTCYELAIGGKTVTIGGAAKGSGMIHPNMATMLGFVTTDAAIEEKALQKALREITD VSFNQITVDGETSTNDMVLVMANGCAENECLTEDHPDWPVFKKALLLTCEDLAKEIAR DGEGATKLIEAQVQGAKNNLDANVIAKKIVGSNLVKTAVYGTDANWGRIIGAIGHSAA QVTAEEVEVYLGGQCLFKNNEPQPFSESIAKEYLEGDEITIVIKMAEGDGNGRAWGCD LTYDYIKINASYRT*" /label="argJ CDS" gene 1076823..1078043 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /label="argJ gene" CDS 1078058..1078834 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /EC_number="2.7.2.8" /experiment="publication(s) with functional evidences, PMID:3005232, 8473852" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3005232, 8473852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase)" /protein_id="NP_389003.1" /db_xref="EnsemblGenomes-Gn:BSU11210" /db_xref="EnsemblGenomes-Tr:CAB12962" /db_xref="GOA:P68729" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR004662" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10193" /db_xref="UniProtKB/Swiss-Prot:P68729" /translation="MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPE ITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGK DGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNAD LAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNS ALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS*" /label="argB CDS" gene 1078058..1078834 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /label="argB gene" CDS 1078831..1079988 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /EC_number="2.6.1.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17012789; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylornithine aminotransferase" /protein_id="NP_389004.2" /db_xref="EnsemblGenomes-Gn:BSU11220" /db_xref="EnsemblGenomes-Tr:CAB12963" /db_xref="GOA:P36839" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10194" /db_xref="UniProtKB/Swiss-Prot:P36839" /translation="MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLG HCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGA IKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTG KGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAA VNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADI IAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ*" /label="argD CDS" gene 1078831..1079988 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /label="argD gene" CDS 1080059..1081114 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 230177, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 230177, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(small subunit)" /protein_id="NP_389005.2" /db_xref="EnsemblGenomes-Gn:BSU11230" /db_xref="EnsemblGenomes-Tr:CAB12964" /db_xref="GOA:P36838" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10195" /db_xref="UniProtKB/Swiss-Prot:P36838" /modified_by="User" /translation="MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPS YKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKW NIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDG NKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGLSNGPGDPKAIQPY LGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMTSQ NHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEWIF DDYLKNVIPARREIAHA*" /label="Delta6_BSU_11230_SNPvariant" gene 1080059..1081114 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /modified_by="User" /label="Delta6_BSU_11230_SNPvariant" Polymorphism join(1080669,1080670) /Source="geneious" /ID="SNP_BsDelta6_1199938_1199943" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=6 /Amino_Acid_Change="GIV -> G" /CDS_Position=612 /Change="-AATTGT" /Codon_Change="GGA,ATT,GTG -> GGG" /Coverage="183 -> 185" /locus_tag="BSU_11230" /Protein_Effect="Deletion" /Reference_Frequency /Reference_Nucleotides="AATTGT" /Variant_Nucleotides /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="Delta6_BSU_11230_SNPvariant" / /modified_by="User" /label="Polymorphism_Delta6" misc_feature complement(1080948..1080967) /Source="Nicolas_upshift_promotors" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1080958) /Source="Nicolas_upshifts" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1081107..1084199 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(large subunit)" /protein_id="NP_389006.3" /db_xref="EnsemblGenomes-Gn:BSU11240" /db_xref="EnsemblGenomes-Tr:CAB12965" /db_xref="GOA:P18185" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR036897" /db_xref="SubtiList:BG10196" /db_xref="UniProtKB/Swiss-Prot:P18185" /translation="MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRV ILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVEL EETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAE SIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEY EVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALD VVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDEL KNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAA IQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHE KTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEV RALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPI RIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVN VAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELG LKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSM PYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGL QQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIP LATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAY DSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHI NLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ *" /label="carB CDS" gene 1081107..1084199 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /label="carB gene" CDS 1084187..1085146 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /EC_number="2.1.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3099126, 6409881, 8025667, 9346304, 16585758, 26443366" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3099126, 6409881, 8025667, 9346304, 16585758, 26443366; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ornithine carbamoyltransferase" /protein_id="NP_389007.1" /db_xref="EnsemblGenomes-Gn:BSU11250" /db_xref="EnsemblGenomes-Tr:CAB12966" /db_xref="GOA:P18186" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="SubtiList:BG10197" /db_xref="UniProtKB/Swiss-Prot:P18186" /translation="MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIF HGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYV DAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAY IGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPI EAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHRE EEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC*" /label="argF CDS" gene 1084187..1085146 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /label="argF gene" downshifts 1085109 /Source="Nicolas_upshifts" /id="D609" /incds=0 /nref=141 /ntot=268 /MaxReadThrough="4.29547" /MaxDrop="7.69347" /score="22.2660758" /energy="-11.1" /TU="U899" /idTUdmin="U899" /TUdmin="-305" /isTUend="FALSE" /label="downshifts" S_feature complement(1085149..1085423) /Source="Nicolas_S_feature" /locus_tag="new_1204423_1204697_c" /HighExp="G135, G180, Cold, LBGexp, G150, B60, LoTm, Paraq, Oxctl, H2O2" /AntisenseName="yjzC" /AntisenseCor="-0.37122740772860502" /AntisenseRegPval="-9.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S399" promotor_-35 1085174..1085180 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1085182) /Source="Nicolas_upshifts" /id="D610" /incds=0 /nref=33 /ntot=166 /MaxReadThrough="1.19008" /MaxDrop="5.22155" /score="16.2777759" /energy="-11.2" /TU="NA" /idTUdmin="U902" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 1085195..1085206 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1085216 /Source="Nicolas_upshifts" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="upshifts" CDS 1085232..1085411 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25859258" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389008.1" /db_xref="EnsemblGenomes-Gn:BSU11260" /db_xref="EnsemblGenomes-Tr:CAB12967" /db_xref="InterPro:IPR025549" /db_xref="SubtiList:BG13223" /db_xref="UniProtKB/Swiss-Prot:O34585" /translation="MGQQHQFRPGQKAPNNGVYVEIGETGSMVKNPQKVHLSAGEMFP ETSNHNRLWTYKRKP*" /label="yjzC CDS" gene 1085232..1085411 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /label="yjzC gene" downshifts 1085421 /Source="Nicolas_upshifts" /id="D611" /incds=0 /nref=19 /ntot=53 /MaxReadThrough="0.25116" /MaxDrop="5.67653" /score="4.8153862" /energy="-10.9" /TU="NA" /idTUdmin="U899" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1085457..1085642) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19775244" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19775244; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore targeted protein" /protein_id="NP_389009.1" /db_xref="EnsemblGenomes-Gn:BSU11270" /db_xref="EnsemblGenomes-Tr:CAB12968" /db_xref="GOA:O34713" /db_xref="InterPro:IPR021324" /db_xref="SubtiList:BG13224" /db_xref="UniProtKB/Swiss-Prot:O34713" /translation="MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVL IMVLAEIMPMNKNASQH*" /label="yjzD CDS" gene complement(1085457..1085642) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /label="yjzD gene" downshifts complement(1085468) /Source="Nicolas_upshifts" /id="D612" /incds=0 /nref=215 /ntot=261 /MaxReadThrough="3.91391" /MaxDrop="6.26103" /score="9.62656276" /energy="-10.9" /TU="U902" /idTUdmin="U902" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1085671..1085690) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1085688) /Source="Nicolas_upshifts" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1085701..1085708) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1085743..1085749 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1085761..1085780 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1085766 /Source="Nicolas_upshifts" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1085823..1085832 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1085832 /Source="Nicolas_upshifts" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1085845..1085864 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1085891..1086625 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 18582593" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389010.1" /db_xref="EnsemblGenomes-Gn:BSU11280" /db_xref="EnsemblGenomes-Tr:CAB12969" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13124" /db_xref="UniProtKB/Swiss-Prot:O35001" /translation="MGITERYFQLGTEHNVIHLPYRPNGFGIFILGDRTHFVGHDSSF WQQHYGRNQLLSMLMNEGYTLFNSNLFGRHWGAEKAVTYAKQLIHSVLKQEILNPKIH ILAEGMGALVADELLRFSPDHIRSAAMLNPCLDLQAHYESEKENKFFYKQFLKEVSKS YGISEKEAEAIRYKTIQSYPSGVPVHIWQRMTGAPYPYSVHAEVFKEKQQKQGSPVDM TFHLFEHPSRIYASICKFFHSHEKEL*" /label="yjaU CDS" gene 1085891..1086625 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /label="yjaU gene" S_feature complement(1086384..1086986) /Source="Nicolas_S_feature" /locus_tag="new_1205658_1206260_c" /HighExp="S8, S6, S7, C30, BT, S4, S5, Pyr, S3, C90" /AntisenseName="yjaV" /AntisenseCor="0.66207512383157796" /AntisenseRegPval="-34.6" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.468" /TUlongSig="NA" /TUlongPSig="NA" /label="S400" promotor_-35 1086606..1086611 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1086624 /Source="Nicolas_upshifts" /id="D613" /incds=0 /nref=6 /ntot=47 /MaxReadThrough="5.56163" /MaxDrop="4.5381" /score="1.90624641" /energy="-10" /TU="U904,U905" /idTUdmin="U904" /TUdmin="-945" /isTUend="FALSE" /label="downshifts" upshifts 1086624 /Source="Nicolas_upshifts" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1086627..1086645 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1086707..1087264 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P) binding enzyme" /protein_id="NP_389011.2" /db_xref="EnsemblGenomes-Gn:BSU11290" /db_xref="EnsemblGenomes-Tr:CAB12970" /db_xref="SubtiList:BG13125" /db_xref="UniProtKB/Swiss-Prot:O34959" /translation="MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYL EERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKR EKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTE KTSKEEAKTKIIEWKRQFSSIFDKY*" /label="yjaV CDS" gene 1086707..1087264 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /label="yjaV gene" promotor_-10 complement(1086966..1086985) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1086986) /Source="Nicolas_upshifts" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1087000..1087004) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1087271..1087278 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1087293..1087312 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1087305 /Source="Nicolas_upshifts" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1087355..1088308 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1203607, 21622736, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1203607, 21622736, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="positive regulator of comK" /protein_id="NP_389012.2" /db_xref="EnsemblGenomes-Gn:BSU11300" /db_xref="EnsemblGenomes-Tr:CAB12971" /db_xref="GOA:O32436" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13126" /db_xref="UniProtKB/Swiss-Prot:O32436" /translation="MITRLVMIFSVLLLLSGCGQTPFKGKIEKVGMLFPDTINDLVWG TKGYKGLLNIQSKYNVDVYYKEGVKTEEDIINAIEDFHKRGVNLLYGHGSEYAEVFNL VGEDYPDMEFVISNAKAKADNVTSVHFSGEAMGFFGGMTAAHMSKTNQVGVIASFTWQ PEVDGFIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKNEGADVVYPAGDGYNVP VIQQIKKDGLYAIGYVTDQSDLGENTVLTSTVQNVDKAYEIIAEQFNKGTLEGGDHYY DLNTGVVEMGTFSPLVDQDFQQRIAKLIKTYNKTGELPKNE*" /label="med CDS" gene 1087355..1088308 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /label="med gene" promotor_-35 1087972..1087976 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1087992..1088011 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1088005 /Source="Nicolas_upshifts" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1088323..1088514 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10940045; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative late competence gene" /protein_id="NP_389013.1" /db_xref="EnsemblGenomes-Gn:BSU11310" /db_xref="EnsemblGenomes-Tr:CAB12972" /db_xref="GOA:O32437" /db_xref="InterPro:IPR024558" /db_xref="SubtiList:BG13221" /db_xref="UniProtKB/Swiss-Prot:O32437" /translation="MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFT TVMAEAYELGKSDAKSETE*" /label="comZ CDS" gene 1088323..1088514 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /label="comZ gene" downshifts 1088493 /Source="Nicolas_upshifts" /id="D614" /incds=0 /nref=32 /ntot=192 /MaxReadThrough="4.56858" /MaxDrop="3.45953" /score="-7.49795364" /energy="-10.4" /TU="U907,U908" /idTUdmin="U905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1088538..1088878 /Source="Nicolas_S_feature" /locus_tag="new_1207812_1208152" /HighExp="H2O2, C30, G135, Paraq, G180, G150, Oxctl, Cold, dia15, LPh" /AntisenseName="yjzB" /AntisenseCor="-0.34349942363230701" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S401" CDS complement(1088544..1088783) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /experiment="publication(s) with functional evidences, PMID:16391061, 22171814, 27227299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16391061, 22171814, 27227299; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389014.1" /db_xref="EnsemblGenomes-Gn:BSU11320" /db_xref="EnsemblGenomes-Tr:CAB12973" /db_xref="SubtiList:BG13222" /db_xref="UniProtKB/Swiss-Prot:O34891" /translation="MQLDVFSRMMFGDAAKPTEEKEEEQQEEVSQVSQTNDEETINYM HIMDQIGSIMNSLDQIKPALKELAPMLSAIKKKIM*" /label="yjzB CDS" gene complement(1088544..1088783) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /label="yjzB gene" downshifts complement(1088560) /Source="Nicolas_upshifts" /id="D615" /incds=0 /nref=21 /ntot=48 /MaxReadThrough="1.43519" /MaxDrop="5.47891" /score="-7.75082002" /energy="-10.4" /TU="NA" /idTUdmin="U909" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1088796..1088815) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1088817) /Source="Nicolas_upshifts" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1088829..1088838) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1088844..1088851 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1088866..1088885 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1088880 /Source="Nicolas_upshifts" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="upshifts" CDS 1088948..1089886 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 11959561, 21542858, 25196128" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 11959561, 21542858, 25196128; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 1" /protein_id="NP_389015.1" /db_xref="EnsemblGenomes-Gn:BSU11330" /db_xref="EnsemblGenomes-Tr:CAB12974" /db_xref="GOA:O34746" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13127" /db_xref="UniProtKB/Swiss-Prot:O34746" /translation="MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRI AADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKK ACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCV NVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPIS LVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR*" /label="fabHA CDS" gene 1088948..1089886 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /label="fabHA gene" promotor_-35 1089025..1089034 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1089043 /Source="Nicolas_upshifts" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1089046..1089061 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1089909..1091150 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /EC_number="2.3.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11325930, 12682299, 16436705, 18384517, 21542858, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325930, 12682299, 16436705, 18384517, 21542858, 28196402; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase II (involved in pimelate synthesis)" /protein_id="NP_389016.1" /db_xref="EnsemblGenomes-Gn:BSU11340" /db_xref="EnsemblGenomes-Tr:CAB12975" /db_xref="GOA:O34340" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR017568" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020841" /db_xref="PDB:4LS5" /db_xref="PDB:4LS6" /db_xref="PDB:4LS7" /db_xref="PDB:4LS8" /db_xref="SubtiList:BG13128" /db_xref="UniProtKB/Swiss-Prot:O34340" /translation="MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAE EYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVG VWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTA SRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDG EGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSST KSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYV LSNSLGFGGHNATLIFKKYQS*" /label="fabF CDS" gene 1089909..1091150 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /label="fabF gene" promotor_-10 complement(1090123..1090141) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1090131) /Source="Nicolas_upshifts" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1090157..1090162) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1091001 /Source="Nicolas_upshifts" /id="D616" /incds=1 /nref=1 /ntot=89 /MaxReadThrough="7.03006" /MaxDrop="2.1101" /score="54.6350161" /energy="-18.5" /TU="U910,U911" /idTUdmin="U911" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 1091134 /Source="Nicolas_upshifts" /id="D617" /incds=0 /nref=246 /ntot=274 /MaxReadThrough="0.58964" /MaxDrop="7.80446" /score="54.6350161" /energy="-18.5" /TU="NA" /idTUdmin="U911" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 1091175..1091184 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-35" promotor_-10 1091197..1091216 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-10" upshifts 1091199 /Source="Nicolas_upshifts" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="upshifts" promotor_-35 1091211..1091219 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1091226..1092011 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389017.1" /db_xref="EnsemblGenomes-Gn:BSU11350" /db_xref="EnsemblGenomes-Tr:CAB12992" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13129" /db_xref="UniProtKB/Swiss-Prot:O31596" /translation="MSVEQTYSWLRKAGSIDDLAHYIIPLFSGAEKKNWKGILGHLQH HGMFKNIKEGIQTVSKLKEKGFYGHIQKEEQYLKNKWQGPDVPIVTLPVDERNRRIRL EFGSKSGLAFQDKMFLFLSSDLDFGSVSALMTHEYHHVCRLGHLTKEEKDVTLLDTII MEGLAEYAVYERFGRSQTAEWTTWYTPEQLQALYEKKIAPHRDIKRDNRLFPQLLFGK GYQPKMLGYAVGFNIVKKYLTASKASTADGLSIPAETFLDAML*" /label="yjaZ CDS" gene 1091226..1092011 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /label="yjaZ gene" promotor_-10 1091231..1091249 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1091243 /Source="Nicolas_upshifts" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1092012..1092096 /Source="Nicolas_S_feature" /locus_tag="new_1211286_1211370" /HighExp="S6, S5, S8, S7, BT, S4, S3, B36, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S402" promotor_-10 complement(1092028..1092046) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1092045) /Source="Nicolas_upshifts" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1092061..1092066) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1092064..1092071 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1092086..1092105 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1092098..1092202 /Source="Nicolas_S_feature" /locus_tag="new_1211372_1211476" /HighExp="LoTm, T4.0H, T3.0H, T5.0H, T3.30H, T2.30H, M9-stat, S1, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S403" upshifts 1092098 /Source="Nicolas_upshifts" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1092203..1093189 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389018.1" /db_xref="EnsemblGenomes-Gn:BSU11360" /db_xref="EnsemblGenomes-Tr:CAB12993" /db_xref="GOA:P42064" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11085" /db_xref="UniProtKB/Swiss-Prot:P42064" /translation="MSTLLEVNNLKTYFFRKKEPIPAVDGVDFHISKGETVALVGESG SGKSITSLSIMGLVQSSGGKIMDGSIKLEDKDLTSFTENDYCKIRGNEVSMIFQEPMT SLNPVLTIGEQITEVLIYHKNMKKKEARQRAVELLQMVGFSRAEQIMKEYPHRLSGGM RQRVMIAIALSCNPKLLIADEPTTALDVTIQAQVLELMKDLCQKFNTSILLITHDLGV VSEAADRVIVMYCGQVVENATVDDLFLEPLHPYTEGLLTSIPVIDGEIDKLNAIKGSV PTPDNLPPGCRFAPRCPKAMDKCWTNQPSLLTHKSGRTVRCFLYEEEGAEQS*" /label="appD CDS" gene 1092203..1093189 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /label="appD gene" CDS 1093186..1094175 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389019.2" /db_xref="EnsemblGenomes-Gn:BSU11370" /db_xref="EnsemblGenomes-Tr:CAB12994" /db_xref="GOA:P42065" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11086" /db_xref="UniProtKB/Swiss-Prot:P42065" /translation="MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLK KGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQM VFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHE FSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFIS HDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRE RIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS*" /label="appF CDS" gene 1093186..1094175 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /label="appF gene" misc_feature 1094181..1094187 /Source="Nicolas_upshift_promotors" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1094186..1094262 /Source="Nicolas_S_feature" /locus_tag="new_1213460_1213536" /HighExp="T2.0H, S1, M9-stat, T5.0H, T3.0H, T1.30H, S2, M0t90, T2.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="SigK" /TUlongPSig=1 /label="S404" upshifts 1094186 /Source="Nicolas_upshifts" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1094263..1094754 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15588833, 25355936; Product type rc: receptor" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); N-terminal part of AppA" /translation="MKRRKTALMMLSVLMVLAIFLSACSGSKSSNSSAKKSAGKPQQG GDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGG LAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEKKAITKS CLS*" /label="appAn CDS" gene 1094263..1094754 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /pseudo /label="appAn gene" CDS 1094727..1095893 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7997159, 15588833, 26728191; Product type lp: lipoprotein" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); C-terminal part of AppA" /translation="GDYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENE FNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDTVTYKVIPDANAAVAQLQA GDINFFNVPATDYKTAEKFNNLKIVTDLALSYVYIGWNEKNELFKDKKVRQALTTALD RESIVSQVLDGDGEVAYIPESPLSWNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGD GILDKDGKKFSFTLKTNQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPP NWDFDAMVMGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKWWLAK*" /label="appAc CDS" gene 1094727..1095893 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /pseudo /label="appAc gene" downshifts 1095884 /Source="Nicolas_upshifts" /id="D618" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="7.71397" /MaxDrop="3.11667" /score="-1.00317393" /energy="-13.3" /TU="U916,U917" /idTUdmin="U913" /TUdmin=1715 /isTUend="FALSE" /label="downshifts" CDS 1095969..1096919 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389021.2" /db_xref="EnsemblGenomes-Gn:BSU11390" /db_xref="EnsemblGenomes-Tr:CAB12996" /db_xref="GOA:P42062" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11088" /db_xref="UniProtKB/Swiss-Prot:P42062" /translation="MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKIS QADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLL MLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNL GWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRT ARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDS AFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY*" /label="appB CDS" gene 1095969..1096919 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /label="appB gene" CDS 1096936..1097847 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389022.1" /db_xref="EnsemblGenomes-Gn:BSU11400" /db_xref="EnsemblGenomes-Tr:CAB12997" /db_xref="GOA:P42063" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11089" /db_xref="UniProtKB/Swiss-Prot:P42063" /translation="MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAV ILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVS LLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKP GVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALG PIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPG LFILMTVLCFNFVGDGLRDALDPKNIK*" /label="appC CDS" gene 1096936..1097847 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /label="appC gene" downshifts 1097861 /Source="Nicolas_upshifts" /id="D619" /incds=0 /nref=62 /ntot=188 /MaxReadThrough="5.13927" /MaxDrop="5.50153" /score="22.0028545" /energy="-11.6" /TU="U916,U917" /idTUdmin="U916" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" S_feature 1097906..1098013 /Source="Nicolas_S_feature" /locus_tag="new_1217180_1217287" /HighExp="LoTm, S1, S2, BT, T3.30H, T4.0H, T5.0H, T3.0H, Glu, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S405" promotor_-35 1097986..1097991 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1098007..1098025 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1098015 /Source="Nicolas_upshifts" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1098052..1098804 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717292, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation nucleic acid binding protein" /protein_id="NP_389023.1" /db_xref="EnsemblGenomes-Gn:BSU11410" /db_xref="EnsemblGenomes-Tr:CAB12998" /db_xref="InterPro:IPR020909" /db_xref="SubtiList:BG13130" /db_xref="UniProtKB/Swiss-Prot:O31597" /translation="MLFLHDVWVNWFEGEENGYNVCHFHEWRKEDTVELLDQVPLLRV PSVLFHYIENDLSELPKGLLEDVHQKSYIRKNHERTKLEYCFVVTDGIGILAVDTIGY TIPVRKSRLIPRQEQLVYEMVKDVEPETYEFEPKKLESSKEYHILSLAPEHVRGLTRK ERQIKQLMFMALDQLKGLKNRAEIGYWYTEWNPHMYEQIKRMSFEEIWDMLYNETIEG WSDKHLAFCENLIKGQPFFEKLWEMENESKVN*" /label="yjbA CDS" gene 1098052..1098804 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /label="yjbA gene" downshifts 1098784 /Source="Nicolas_upshifts" /id="D620" /incds=0 /nref=32 /ntot=112 /MaxReadThrough="1.07428" /MaxDrop="6.2264" /score="22.0028545" /energy="-11.6" /TU="NA" /idTUdmin="U916" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1098839..1099831) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /EC_number="6.1.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8950174, 10706627, 12682299, 24572018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8950174, 10706627, 12682299, 24572018; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophanyl-tRNA synthetase" /protein_id="NP_389024.1" /db_xref="EnsemblGenomes-Gn:BSU11420" /db_xref="EnsemblGenomes-Tr:CAB12999" /db_xref="GOA:P21656" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024109" /db_xref="PDB:3PRH" /db_xref="SubtiList:BG10799" /db_xref="UniProtKB/Swiss-Prot:P21656" /translation="MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQH AITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGE LERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAE RFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKI KSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEV VVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR*" /label="trpS CDS" gene complement(1098839..1099831) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /label="trpS gene" downshifts complement(1098860) /Source="Nicolas_upshifts" /id="D621" /incds=0 /nref=224 /ntot=255 /MaxReadThrough="1.77115" /MaxDrop="6.72647" /score="27.6275522" /energy="-11.6" /TU="U919" /idTUdmin="U919" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" misc_RNA complement(1099890..1100104) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /product="T-box riboswitch specific of tryptophan tRNA" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboWA RNA" gene complement(1099890..1100104) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /label="tboWA gene" downshifts complement(1099938) /Source="Nicolas_upshifts" /id="D622" /incds=0 /nref=37 /ntot=127 /MaxReadThrough="6.8472" /MaxDrop="5.13001" /score="25.1445248" /energy="-19" /TU="U919" /idTUdmin="U919" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" misc_feature complement(1100123..1100142) /Source="Nicolas_upshift_promotors" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1100136) /Source="Nicolas_upshifts" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1100391..1100398 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1100412..1100574 /Source="Nicolas_S_feature" /locus_tag="new_1219686_1219848" /HighExp="S1, T3.0H, T3.30H, T2.30H, T4.0H, T5.0H, LoTm, T2.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S406" promotor_-10 1100413..1100432 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1100413 /Source="Nicolas_upshifts" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1100575..1102212 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (binding lipoprotein)" /protein_id="NP_389025.1" /db_xref="EnsemblGenomes-Gn:BSU11430" /db_xref="EnsemblGenomes-Tr:CAB13000" /db_xref="GOA:P24141" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10771" /db_xref="UniProtKB/Swiss-Prot:P24141" /translation="MKKRWSIVTLMLIFTLVLSACGFGGSGSNGEGKKDSKGKTTLNI NIKTEPFSLHPGLANDSVSGGVIRQTFEGLTRINADGEPEEGMASKIETSKDGKTYTF TIRDGVKWSNGDPVTAQDFEYAWKWALDPNNESQYAYQLYYIKGAEAANTGKGSLDDV AVKAVNDKTLKVELNNPTPYFTELTAFYTYMPINKKIAEKNKKWNTNAGDDYVSNGPF KMTAWKHSGSITLEKNDQYWDKDKVKLKKIDMVMINNNNTELKKFQAGELDWAGMPLG QLPTESLPTLKKDGSLHVEPIAGVYWYKFNTEAKPLDNVNIRKALTYSLDRQSIVKNV TQGEQIPAMAAVPPTMKGFEDNKEGYFKDNDVKTAKEYLEKGLKEMGLSKASDLPKIK LSYNTDDAHAKIAQAVQEMWKKNLGVDVELDNSEWNVYIDKLHSQDYQIGRMGWLGDF NDPINFLELFRDKNGGNNDTGWENPEFKKLLNQSQTETDKTKRAELLKKAEGIFIDEM PVAPIYFYTDTWVQDENLKGVIMPGTGEVYFRNAYFK*" /label="oppA CDS" gene 1100575..1102212 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /label="oppA gene" downshifts 1102106 /Source="Nicolas_upshifts" /id="D623" /incds=1 /nref=8 /ntot=166 /MaxReadThrough="6.94127" /MaxDrop="3.3677" /score="-4.2761508" /energy="-15.6" /TU="U920" /idTUdmin="U916" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 1102213..1102319 /Source="Nicolas_S_feature" /locus_tag="new_1221487_1221593" /HighExp="S1, LoTm, T4.0H, BT, T3.30H, T3.0H, T5.0H, M0t90, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S407" CDS 1102320..1103255 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 17600541, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 17600541, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389026.1" /db_xref="EnsemblGenomes-Gn:BSU11440" /db_xref="EnsemblGenomes-Tr:CAB13001" /db_xref="GOA:P24138" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10772" /db_xref="UniProtKB/Swiss-Prot:P24138" /translation="MLKYIGRRLVYMIITLFVIVTVTFFLMQAAPGGPFSGEKKLPPE IEANLNAHYGLDKPLFVQYVSYLKSVAMWDFGPSFKYKGQSVNDLISSGFPVSFTLGA EAILLALALGVLFGVIAALYHNKWQDYTVAILTIFGISVPSFIMAAVLQYVFSMKLGL FPVAGWDSWAYTFLPSIALASMPMAFIARLSRSSMIEVLNSDYIRTAKAKGLSRPAVT VRHAIRNALLPVVTYMGPMAAQVLTGSFIIETIFGIPGLGAHFVNSITNRDYTVIMGV TVFFSVILLLCVLIVDVLYGIIDPRIKLSKAKKGA*" /label="oppB CDS" gene 1102320..1103255 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /label="oppB gene" promotor_-10 complement(1102363..1102382) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1102380) /Source="Nicolas_upshifts" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1102398..1102404) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1103259..1104176 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 26782429" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 26782429; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389027.1" /db_xref="EnsemblGenomes-Gn:BSU11450" /db_xref="EnsemblGenomes-Tr:CAB13002" /db_xref="GOA:P24139" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10773" /db_xref="UniProtKB/Swiss-Prot:P24139" /translation="MQNIPKNMFEPAAANAGDAEKISKKSLSLWKDAMLRFRSNKLAM VGLIIIVLIILMAIFAPMFSRYDYSTTNLLNADKPPSKDHWFGTDDLGRDIFVRTWVG ARISIFIGVAAAVLDLLIGVIWGSISGFRGGRTDEIMMRIADILWAVPSLLMVILLMV VLPKGLFTIIIAMTITGWINMARIVRGQVLQLKNQEYVLASQTLGAKTSRLLFKHIVP NAMGSILVTMTLTVPTAIFTEAFLSYLGLGVPAPLASWGTMASDGLPALTYYPWRLFF PAGFICITMFGFNVVGDGLRDALDPKLRK*" /label="oppC CDS" gene 1103259..1104176 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /label="oppC gene" CDS 1104181..1105257 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 19202088, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 19202088, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389028.1" /db_xref="EnsemblGenomes-Gn:BSU11460" /db_xref="EnsemblGenomes-Tr:CAB13003" /db_xref="GOA:P24136" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10774" /db_xref="UniProtKB/Swiss-Prot:P24136" /translation="MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVG ESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQD PMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFS GGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHD LGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAI PGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPP EAVKAKMRKLANTFEKPVLVREVE*" /label="oppD CDS" gene 1104181..1105257 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /label="oppD gene" CDS 1105259..1106176 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 7997159, 11401703, 23133654, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 7997159, 11401703, 23133654, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389029.1" /db_xref="EnsemblGenomes-Gn:BSU11470" /db_xref="EnsemblGenomes-Tr:CAB13004" /db_xref="GOA:P24137" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10775" /db_xref="UniProtKB/Swiss-Prot:P24137" /translation="MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGES GCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNP RMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIG IARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYIS DRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQ LKDGETMEFREVKPGHFVMCTEAEFKAFS*" /label="oppF CDS" gene 1105259..1106176 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /label="oppF gene" downshifts 1106146 /Source="Nicolas_upshifts" /id="D624" /incds=0 /nref=21 /ntot=196 /MaxReadThrough="1.58906" /MaxDrop="5.17491" /score="28.2861081" /energy="-15.2" /TU="NA" /idTUdmin="U920" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 1106226..1106229 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1106242 /Source="Nicolas_upshifts" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1106244..1106263 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1106283..1107500 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563878, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_389030.2" /db_xref="EnsemblGenomes-Gn:BSU11480" /db_xref="EnsemblGenomes-Tr:CAB13005" /db_xref="GOA:O31600" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13131" /db_xref="UniProtKB/Swiss-Prot:O31600" /translation="MQFLHNKNVFALLLSQSFQSLAGVLVTIVLMVRIYQMTDSVFLA GLILSFMSFASIAASFCVSPVLRILGFKKVLAGANLLRAVFIILMAYSVTHHGQAFFW ITLLFVFCFSFAGAFFQPARFALLPIIVPKKQYVKANGVISLSNQLFLTAGWGLGGLL TYAVPFELVVGAAICLFVLSGASISVLHVNEEEAAGTAETASVRSIWKDLMIIPIVRD ITVMDMLEALAGSVWSSAILLAFTAAVLHETEVWWGMFNASYFIGAIVGSVIAIRFSS FFERNMGYAIMFSSLVMSALTLLFSFSPVPFLCALACAAMGPFYQVRDICQETMLQEV IPEQKRIGIMAAKNAILTPWSGVTYSIMGLVADAAGAKIAFIAAAALYIMTFLIALAQ PRLVHYRRENRVQ*" /label="yjbB CDS" gene 1106283..1107500 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /label="yjbB gene" promotor_-35 1107553..1107562 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-35" promotor_-10 1107575..1107590 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-10" S_feature 1107584..1107663 /Source="Nicolas_S_feature" /locus_tag="new_1226858_1226937" /HighExp="Etha, B60, M9-stat, T0.30H, Salt, T3.0H, T1.0H, T4.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S408" upshifts 1107584 /Source="Nicolas_upshifts" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="upshifts" CDS 1107664..1108242 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17158660, 17158663, 21815947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol oxidation management factor; putative acetyltransferase" /protein_id="NP_389031.2" /db_xref="EnsemblGenomes-Gn:BSU11490" /db_xref="EnsemblGenomes-Tr:CAB13006" /db_xref="GOA:O31601" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13132" /db_xref="UniProtKB/Swiss-Prot:O31601" /translation="MNWYEKLSEYFPIEEMKSKAHMEALLKERSDIYHKDEGKHHILM FAEFDSFIFVDYLYVSKDARGQGLGGKLIAKLKKKNKPILLEVEPVDEDDTDTEKRLR FYQREHFKHAQSIGYRRRSLATNEVNKMEILYWSPKTESEEEILEAMKQTYENIHTYK DEKWYGESYEKTDEVLEIIDEEKQKNIFDQLS*" /label="yjbC CDS" gene 1107664..1108242 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /label="yjbC gene" S_feature 1108243..1108357 /Source="Nicolas_S_feature" /locus_tag="new_1227517_1227631" /HighExp="B60, Etha, Salt, T0.30H, M9-stat, LoTm, Gly, T1.0H, B36, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S409" promotor_-10 complement(1108294..1108313) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1108298) /Source="Nicolas_upshifts" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1108327..1108334) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1108360..1108373 /Source="Nicolas_upshift_promotors" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1108360 /Source="Nicolas_upshifts" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="upshifts" CDS 1108423..1108818 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="redox-sensitive regulator" /protein_id="NP_389032.1" /db_xref="EnsemblGenomes-Gn:BSU11500" /db_xref="EnsemblGenomes-Tr:CAB13007" /db_xref="GOA:O31602" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR023731" /db_xref="InterPro:IPR036249" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG13133" /db_xref="UniProtKB/Swiss-Prot:O31602" /translation="MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQ ILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQ VGYNEDEIRRFLPRKVRSFQLREAQRLAN*" /label="spxA CDS" gene 1108423..1108818 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /label="spxA gene" promotor_no_box complement(1108654..1108754) /Source="Nicolas_upshift_promotors" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1108694) /Source="Nicolas_upshifts" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1108816 /Source="Nicolas_upshifts" /id="D625" /incds=0 /nref=263 /ntot=269 /MaxReadThrough="4.34531" /MaxDrop="8.0579" /score="7.42972561" /energy="-8.8" /TU="U923" /idTUdmin="U925" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1108861..1109650 /Source="Nicolas_S_feature" /locus_tag="new_1228135_1228924" /HighExp="B60, B36, Etha, M9-stat, Salt, H2O2, Paraq, Cold, G180, G135" /AntisenseName="yjbE" /AntisenseCor="-0.18634010398760401" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S410" CDS complement(1108861..1109517) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389033.1" /db_xref="EnsemblGenomes-Gn:BSU11510" /db_xref="EnsemblGenomes-Tr:CAB13008" /db_xref="GOA:O31603" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022301" /db_xref="SubtiList:BG13134" /db_xref="UniProtKB/Swiss-Prot:O31603" /translation="MEHDYLISLLVIVGIDLILGGDNAVVIAMASRHLPDKQRQQAII LGTFIAVAMRIGLTSAAVYLLNIPFLQCAGGIFLLYLGYQLLIEKKDTKHIKSSTSLW RAIRTIVLADLFMSLDNVIAVAGASHGEFSLVVIGLCVSVPVIIWGSKLIHIALEKIP LLIYAGSGLLAYTGGEMIVRDKKLSLFMAQHGTVETLLPILTVAFVILASIYYQQVEK *" /label="yjbE CDS" gene complement(1108861..1109517) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /label="yjbE gene" promotor_-10 complement(1109547..1109565) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1109562) /Source="Nicolas_upshifts" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1109580..1109585) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1109623..1109630 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1109644..1109663 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1109652..1109793 /Source="Nicolas_S_feature" /locus_tag="new_1228926_1229067" /HighExp="B60, Diami, Etha, dia5, LPhT, M9-stat, T5.0H, T3.0H, dia15, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S411" upshifts 1109652 /Source="Nicolas_upshifts" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="upshifts" CDS 1109687..1109827 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513949.1" /translation="MVKVKMWTEWVKCSKVQLIGSLDVPSTSYIEGKVGKWKLKELTS IQ*" /label="conserved hypothetical protein CDS" gene 1109687..1109827 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /label="gene" CDS 1109794..1110450 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10361283, 10447896, 16525504, 19801546, 21435029, 23595989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor" /codon_start=1 /transl_table=11 /product="adaptor protein controlling oligomerization of the AAA+ protein ClpC" /protein_id="NP_389034.1" /db_xref="EnsemblGenomes-Gn:BSU11520" /db_xref="EnsemblGenomes-Tr:CAB13009" /db_xref="GOA:P37958" /db_xref="InterPro:IPR008681" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3JTP" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="SubtiList:BG10680" /db_xref="UniProtKB/Swiss-Prot:P37958" /translation="MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEV MDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASE DLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS *" /label="mecA CDS" gene 1109794..1110450 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /label="mecA gene" downshifts 1110440 /Source="Nicolas_upshifts" /id="D626" /incds=0 /nref=120 /ntot=308 /MaxReadThrough="5.41786" /MaxDrop="7.67172" /score="32.2431225" /energy="-11.8" /TU="U928" /idTUdmin="U928" /TUdmin="-774" /isTUend="FALSE" /label="downshifts" CDS complement(1110445..1110567) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513950.1" /translation="MINSCSLYFLLVYMFLIFHISKMAFSCIKKTDFRKEIGLL*" /label="conserved hypothetical protein CDS" gene complement(1110445..1110567) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /label="gene" S_feature 1110485..1110574 /Source="Nicolas_S_feature" /locus_tag="new_1229759_1229848" /HighExp="Etha, M9-stat, B60, dia15, T0.30H, Diami, C30, H2O2, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S412" promotor_-35 1110553..1110561 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1110572..1110590 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1110576..1110640 /Source="Nicolas_S_feature" /locus_tag="new_1229850_1229914" /HighExp="Etha, G/S, GM 150, T-4.40H, S2, T-2.40H, Pyr, C90, M9-tran, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.876, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S413" upshifts 1110576 /Source="Nicolas_upshifts" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1110641..1111762 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10438773, 17630974, 23046409, 26880300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438773, 17630974, 23046409, 26880300; Product type s: structure" /codon_start=1 /transl_table=11 /product="protein involved in establishment of DNA transport in competence" /protein_id="NP_389035.1" /db_xref="EnsemblGenomes-Gn:BSU11530" /db_xref="EnsemblGenomes-Tr:CAB13010" /db_xref="GOA:O31604" /db_xref="InterPro:IPR010330" /db_xref="InterPro:IPR021176" /db_xref="SubtiList:BG13135" /db_xref="UniProtKB/Swiss-Prot:O31604" /translation="MFHLLGAQQNQKLKRRRFFCPVCGGELAVKLGLQKAPHFAHKQN KSCAIDIEPESAYHLEGKRQLYVWLKTQRASPILEPYIRTINQRPDVMARIKEHMLAV EYQCATIAPDVFQKRTEGFKQEGIIPQWIMGYSRLKRTASSFYQLSTFHWQFINASPY RELICYCPERRSFLRLSHIIPFYTNHSYSSVQTIPIHRAGAGDLFFTEPKPSIQYSGW TKAIHRFRHKPHRFNSKETNRLRLLFYEKRQTPFSFLPTEVFVPVRKGAVFKSPVFVW QGFLYLFMTDLGGKRAPIRFSAVLQQCKLHIHNKNIALRSECSEECLSEAVKQYIDFL CKKGFLRETQKEVYVLNQPAGGIHSMQDLIERDRSCFIE*" /label="coiA CDS" gene 1110641..1111762 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /label="coiA gene" promotor_-35 1111416..1111422 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" upshifts 1111434 /Source="Nicolas_upshifts" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-10 1111437..1111455 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" promotor_-35 1111648..1111656 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" promotor_-10 1111668..1111686 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" upshifts 1111675 /Source="Nicolas_upshifts" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-35 1111756..1111762 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1111777..1111788 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1111786 /Source="Nicolas_upshifts" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1111809..1113821 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11741842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11741842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoendopeptidase F" /protein_id="NP_389036.2" /db_xref="EnsemblGenomes-Gn:BSU11540" /db_xref="EnsemblGenomes-Tr:CAB13011" /db_xref="GOA:O31605" /db_xref="InterPro:IPR001567" /db_xref="InterPro:IPR004438" /db_xref="InterPro:IPR013647" /db_xref="SubtiList:BG13136" /db_xref="UniProtKB/Swiss-Prot:O31605" /translation="MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLR NSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAV KELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGL NDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVL SEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESEN REVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEE VYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYM LKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNN LFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQR LYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDG MVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAG SSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS*" /label="pepF CDS" gene 1111809..1113821 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /label="pepF gene" promotor_-35 1111884..1111891 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-35" promotor_-10 1111906..1111925 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-10" upshifts 1111918 /Source="Nicolas_upshifts" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="upshifts" downshifts 1113768 /Source="Nicolas_upshifts" /id="D627" /incds=0 /nref=98 /ntot=339 /MaxReadThrough="4.70576" /MaxDrop="5.74441" /score="19.0969124" /energy="-15.2" /TU="U933" /idTUdmin="U931" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 1113822..1114123 /Source="Nicolas_S_feature" /locus_tag="new_1233096_1233397" /HighExp="Etha, dia15, Diami, B60, M9-stat, S8, M0t90, dia5, B36, T0.30H" /AntisenseName="yizD" /AntisenseCor="-1.29003203536192E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="SigH, SigB" /TUlongPSig="0.999, 0.999" /label="S414" CDS complement(1113859..1114026) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097703.1" /db_xref="EnsemblGenomes-Gn:BSU11549" /db_xref="EnsemblGenomes-Tr:CAX52593" /db_xref="GOA:C0H3Y6" /db_xref="UniProtKB/Swiss-Prot:C0H3Y6" /translation="MMSTLISIVCIAVFFCLNILGMMHMLPLYITSPLLFLSILFTLY RLNHRKTFKGF*" /label="yizD CDS" gene complement(1113859..1114026) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /label="yizD gene" downshifts complement(1113872) /Source="Nicolas_upshifts" /id="D628" /incds=0 /nref=8 /ntot=61 /MaxReadThrough="1.527" /MaxDrop="5.54041" /score="-4.56163992" /energy="-15.2" /TU="NA" /idTUdmin="U934" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1114046..1114064) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1114062) /Source="Nicolas_upshifts" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1114080..1114085) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1114116..1114123 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1114125..1114250 /Source="Nicolas_S_feature" /locus_tag="new_1233399_1233524" /HighExp="B36, T-1.10H, nit, T-0.40H, M9-tran, LoTm, Pyr, Etha, Salt, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.883" /TUlongSig="SigA, SigH, SigB" /TUlongPSig="0.926, 0.999, 0.999" /label="S415" upshifts 1114125 /Source="Nicolas_upshifts" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1114131..1114269 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /product="small regulatory RNA (NO regulated)" /experiment="publication(s) with functional evidences, PMID:19682248, 19786493, 20511587, 20525796, 25643072, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682248, 19786493, 20511587, 20525796, 25643072, 28436820; Product type n : RNA" /label="roxS RNA" gene 1114131..1114269 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /label="roxS gene" promotor_-10 1114138..1114157 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1114207 /Source="Nicolas_upshifts" /id="D629" /incds=0 /nref=96 /ntot=135 /MaxReadThrough="3.50613" /MaxDrop="9.07209" /score="5.30186633" /energy="-11.6" /TU="U935" /idTUdmin="U933" /TUdmin=89 /isTUend="FALSE" /label="downshifts" CDS complement(1114340..1115239) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiol management effector of SpxA degradation" /protein_id="NP_389037.2" /db_xref="EnsemblGenomes-Gn:BSU11550" /db_xref="EnsemblGenomes-Tr:CAB13012" /db_xref="GOA:O31606" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13137" /db_xref="UniProtKB/Swiss-Prot:O31606" /translation="MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKL KIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLS SPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEF KKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEIL FEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKV EAKHGMFWKSLSTYSDEYQSCEK*" /label="spxH CDS" gene complement(1114340..1115239) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /label="spxH gene" downshifts complement(1114371) /Source="Nicolas_upshifts" /id="D630" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="3.70729" /MaxDrop="5.65601" /score="17.9327625" /energy="-13.3" /TU="U937" /idTUdmin="U937" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1114575..1114580 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1114587 /Source="Nicolas_upshifts" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1114596..1114614 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1114603..1116504 /Source="Nicolas_S_feature" /locus_tag="new_1233877_1235778" /HighExp="S6, S4, S5, S8, S3, S7, BT, B36, C30, T5.0H" /AntisenseName="yjbH" /AntisenseCor="-0.61019541931037402" /AntisenseRegPval="-28.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S416" CDS complement(1115236..1115634) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15866723, 17293416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol management oxidoreductase component" /protein_id="NP_389038.1" /db_xref="EnsemblGenomes-Gn:BSU11560" /db_xref="EnsemblGenomes-Tr:CAB13013" /db_xref="GOA:O31607" /db_xref="InterPro:IPR001486" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR019795" /db_xref="PDB:1UX8" /db_xref="SubtiList:BG13138" /db_xref="UniProtKB/Swiss-Prot:O31607" /translation="MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTE TARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGL EGEIREFLFGRLELTARHMVNQTEAEDRSS*" /label="yjbI CDS" gene complement(1115236..1115634) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /label="yjbI gene" S_feature complement(1115635..1115814) /Source="Nicolas_S_feature" /locus_tag="new_1234909_1235088_c" /HighExp="Diami, dia5, dia15, Etha, H2O2, C90, LoTm, Heat, Salt, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.999" /label="S417" promotor_-10 complement(1115806..1115825) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1115814) /Source="Nicolas_upshifts" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1115837..1115844) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1115889..1116434) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /EC_number="3.2.1.-" /EC_number="3.2.1.17" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:20609359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20609359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional muramidase and murein lytic transglycosylase" /protein_id="NP_389039.1" /db_xref="EnsemblGenomes-Gn:BSU11570" /db_xref="EnsemblGenomes-Tr:CAB13014" /db_xref="GOA:O31608" /db_xref="InterPro:IPR000189" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13139" /db_xref="UniProtKB/Swiss-Prot:O31608" /translation="MLNSANTTAPSLLSAYGLNSYTSSNSGSVTKAAESTETAVADSA SNKHEANQIRSGDFSIDSAIKKAADKYGVDEKLIRAVIKQESGFNAKAVSGAGAMGLM QLMPSTASSLGVSNPLDPQQNVEGGTKYLKQMLDKYDGNVSMALAAYNAGPGNVDRYG GIPPFQETQNYVKKITSVYYA*" /label="cwlQ CDS" gene complement(1115889..1116434) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /label="cwlQ gene" downshifts complement(1115913) /Source="Nicolas_upshifts" /id="D631" /incds=0 /nref=101 /ntot=222 /MaxReadThrough="4.1014" /MaxDrop="5.00847" /score="6.97790581" /energy="-9.1" /TU="U938,U939" /idTUdmin="U938" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" S_feature complement(1116435..1116637) /Source="Nicolas_S_feature" /locus_tag="new_1235709_1235911_c" /HighExp="T0.30H, Gly, C90, GM 10, GM 45, M0t90, Lbstat, C30, Lbtran, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S418" CDS complement(1116638..1117210) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9642185, 12456267, 16905149, 20509597, 26904951, 27881678; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative RNA/thiamine triphosphatase" /protein_id="NP_389040.1" /db_xref="EnsemblGenomes-Gn:BSU11580" /db_xref="EnsemblGenomes-Tr:CAB13015" /db_xref="GOA:O31609" /db_xref="InterPro:IPR009195" /db_xref="InterPro:IPR023577" /db_xref="InterPro:IPR033469" /db_xref="SubtiList:BG13140" /db_xref="UniProtKB/Swiss-Prot:O31609" /translation="MSQEIEIEFKNMLTKQEFKNIASALQLTEKDFTDQKNHYFDTDS FALKQKHAALRIRRKNGKYVLTLKEPADVGLLETHQQLSEVSDLAGFSVPEGPVKDQL HKLQIDTDAIQYFGSLATNRAEKETEKGLIVLDHSRYLNKEDYEIEFEAADWHEGRQA FEKLLQQFSIPQRETKNKILRFYEEKRKSI*" /label="yjbK CDS" gene complement(1116638..1117210) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /label="yjbK gene" promotor_-10 complement(1116783..1116801) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1116792) /Source="Nicolas_upshifts" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 complement(1116814..1116821) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" promotor_-10 complement(1117239..1117258) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1117256) /Source="Nicolas_upshifts" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 1117272..1117275 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1117273..1117280) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" upshifts 1117288 /Source="Nicolas_upshifts" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1117291..1117310 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1117335..1117703 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389041.1" /db_xref="EnsemblGenomes-Gn:BSU11590" /db_xref="EnsemblGenomes-Tr:CAB13016" /db_xref="InterPro:IPR020908" /db_xref="SubtiList:BG13141" /db_xref="UniProtKB/Swiss-Prot:O31610" /translation="MQNRIEILNATLSDDQLRLACQTEGNEAERKPSGQMLVDSDHFA FVYILELADSFEYVIIKEHVWPELKQAHAQKIPVVLEAGDQTIELAGLHEELEYLLEN IKDNANYGEEMEEKVKRVFL*" /label="yjbL CDS" gene 1117335..1117703 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /label="yjbL gene" CDS 1117732..1118367 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /EC_number="2.7.6.5" /function="16.1: Circulate" /function="16.14: Store" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 24163341, 25331430, 26825398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 24163341, 25331430, 26825398; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_389042.1" /db_xref="EnsemblGenomes-Gn:BSU11600" /db_xref="EnsemblGenomes-Tr:CAB13017" /db_xref="GOA:O31611" /db_xref="InterPro:IPR007685" /db_xref="PDB:5DEC" /db_xref="PDB:5DED" /db_xref="PDB:5F2V" /db_xref="SubtiList:BG13142" /db_xref="UniProtKB/Swiss-Prot:O31611" /translation="MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVT GRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVV DQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYK YSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ*" /label="relP CDS" gene 1117732..1118367 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /label="relP gene" CDS 1118386..1119186 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /EC_number="2.7.1.23" /function="16.14: Store" /function="16.7: Manage energy" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12897004, 16233726, 16511117, 18720024, 24048943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12897004, 16233726, 16511117, 18720024, 24048943; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase (quinolate activated)" /protein_id="NP_389043.1" /db_xref="EnsemblGenomes-Gn:BSU11610" /db_xref="EnsemblGenomes-Tr:CAB13018" /db_xref="GOA:O31612" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13143" /db_xref="UniProtKB/Swiss-Prot:O31612" /translation="MKFAVSSKGDQVSDTLKSKIQAYLLDFDMELDENEPEIVISVGG DGTLLYAFHRYSDRLDKTAFVGVHTGHLGFYADWVPHEIEKLVLAIAKTPYHTVEYPL LEVIVTYHENEREERYLALNECTIKSIEGSLVADVEIKGQLFETFRGDGLCLSTPSGS TAYNKALGGAIIHPSIRAIQLAEMASINNRVFRTVGSPLLLPSHHDCMIKPRNEVDFQ VTIDHLTLLHKDVKSIRCQVASEKVRFARFRPFPFWKRVQDSFIGKGE*" /label="ppnKA CDS" gene 1118386..1119186 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /label="ppnKA gene" CDS 1119249..1120100 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /EC_number="5.4.99.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389044.1" /db_xref="EnsemblGenomes-Gn:BSU11620" /db_xref="EnsemblGenomes-Tr:CAB13019" /db_xref="GOA:O31613" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG13144" /db_xref="UniProtKB/Swiss-Prot:O31613" /translation="MTVKEYAGELGISKRLLTDIKFGGGDLQINGEHVTVKYVLKEGD LLIVKFPEEQVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGII DHYQTTGVRATVHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGR MAQMEGTVDAPIGRHPDSIIERTVTPDGQKAVTHFYVTCANDDMTSVALQLETGRTHQ IRVHMSYLGHPLCGDTLYGGTRQEIGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSK LIKGENH*" /label="yjbO CDS" gene 1119249..1120100 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /label="yjbO gene" downshifts 1120059 /Source="Nicolas_upshifts" /id="D632" /incds=0 /nref=203 /ntot=256 /MaxReadThrough="0.25796" /MaxDrop="5.73002" /score="21.4914497" /energy="-12.8" /TU="NA" /idTUdmin="U940" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1120113..1120847) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /EC_number="3.6.1.17" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12059787, 16740944, 21092197, 23824080, 28516732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12059787, 16740944, 21092197, 23824080, 28516732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase" /protein_id="NP_389045.1" /db_xref="EnsemblGenomes-Gn:BSU11630" /db_xref="EnsemblGenomes-Tr:CAB13020" /db_xref="GOA:O31614" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR023937" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13145" /db_xref="UniProtKB/Swiss-Prot:O31614" /translation="MAYDIISDIHGCYDEMTALIQKLGYTIKNGVPVHEEGRVLVFAG DLTDRGPKSIEVIRFVAGAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAEL EELSKDEKKSVSEQFMKLYETAPLYDILHNGELVVAHAGIRADDIGKYTRRVKDFVLY GDVTGETYPDGRPIRRDWAAAYNGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNQLT GFRFPEIETVSVPSSLPYDESRFRPI*" /label="prpE CDS" gene complement(1120113..1120847) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /label="prpE gene" downshifts complement(1120135) /Source="Nicolas_upshifts" /id="D633" /incds=0 /nref=22 /ntot=152 /MaxReadThrough="1.18091" /MaxDrop="3.57735" /score="3.24324561" /energy="-12.8" /TU="NA" /idTUdmin="U938" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" promotor_-35 1120969..1120973 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-35" promotor_-10 1120990..1121009 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-10" upshifts 1121004 /Source="Nicolas_upshifts" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="upshifts" S_feature 1121005..1121081 /Source="Nicolas_S_feature" /locus_tag="new_1240279_1240355" /HighExp="H2O2, Diami, dia15, Paraq, Oxctl, Heat, G180, Salt, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S419" CDS 1121082..1122926 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 21742892, 24330391; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gated K+/H+ antiporter" /protein_id="NP_389046.1" /db_xref="EnsemblGenomes-Gn:BSU11640" /db_xref="EnsemblGenomes-Tr:CAB13021" /db_xref="GOA:O31615" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13146" /db_xref="UniProtKB/Swiss-Prot:O31615" /translation="MAHTSVASLVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIG KSGLNLVVEGDTWLQTLSMLGFIFLMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFA AASVIFVGIFILSLLLSYGFVLAGFIQNAFLMTLIISTISLGVVVPTLKEERIMNSNI GQIILLVAVIADLATMILLAVFSSLYGEDSGNMWLLMILFAAGVVLYFFGRVFKHRSF VQSMSKGTIQIGTRAIFTLIIVLVALSESLGAENILGAFLAGVLVSLLSPNKELVQQL DSFGYGFLIPIFFVMVGVKLDIWTLFQDKTILIMIPLLLLALLVSKIIPVMYLKKWYD NRTIFASGFLLTSTLSLVIAAATIGQQLHVISTNMSGALILVAVIASIFTPICFKKLY KREEQPEEKKTITFIGANQMTLPVTLELPEEEYDVRVVHVYQENAEEKLSESVFAVET ISDYEHETLESLGIFETDILVVATGNEDMNADIALLAKDKGTERVIASVGSPEHEAAL KEQGISIFSILLSTKTLLRALIEAPGVMKLLTNQESSLYQINMENSKYDGVILREFPL TGDVIFVRIFRGVDSIVPHGDTRLKLGDRLIVTGSRGYVTDLKKTLEG*" /label="kefQ CDS" gene 1121082..1122926 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /label="kefQ gene" misc_feature complement(1121409..1121428) /Source="Nicolas_upshift_promotors" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1121433) /Source="Nicolas_upshifts" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1122928..1122935 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-35" promotor_-10 1122949..1122968 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-10" upshifts 1122955 /Source="Nicolas_upshifts" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="upshifts" misc_RNA 1122988..1123096 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswA RNA" gene 1122988..1123096 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /label="tswA gene" downshifts 1123091 /Source="Nicolas_upshifts" /id="D634" /incds=0 /nref=20 /ntot=84 /MaxReadThrough="7.67021" /MaxDrop="5.27759" /score="34.8346124" /energy="-12.5" /TU="U943" /idTUdmin="U941" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS 1123175..1123885 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /EC_number="3.5.99.2" /function="4.11: Thiamine" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 17618314, 18054064, 24311574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 17618314, 18054064, 24311574; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiaminase II" /protein_id="NP_389047.1" /db_xref="EnsemblGenomes-Gn:BSU11650" /db_xref="EnsemblGenomes-Tr:CAB13022" /db_xref="GOA:P25052" /db_xref="InterPro:IPR004305" /db_xref="InterPro:IPR016084" /db_xref="InterPro:IPR027574" /db_xref="PDB:1TO9" /db_xref="PDB:1TYH" /db_xref="PDB:1YAF" /db_xref="PDB:1YAK" /db_xref="PDB:2QCX" /db_xref="SubtiList:BG10791" /db_xref="UniProtKB/Swiss-Prot:P25052" /translation="MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQD SYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKA FKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWI GTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGW SDSAIKEVEECGASRHNG*" /label="tenA CDS" gene 1123175..1123885 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /label="tenA gene" CDS 1123860..1124477 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /EC_number="5.3.99.10" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 21534620" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 21534620; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiazole tautomerase" /protein_id="NP_389048.1" /db_xref="EnsemblGenomes-Gn:BSU11660" /db_xref="EnsemblGenomes-Tr:CAB13023" /db_xref="GOA:P25053" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR036206" /db_xref="PDB:1YAD" /db_xref="PDB:3QH2" /db_xref="SubtiList:BG10792" /db_xref="UniProtKB/Swiss-Prot:P25053" /translation="MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILK LLDLIFEGGIDKRKLVMNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVH SLEEAVQAEKEDADYVLFGHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPD RLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKEMRYEKAL*" /label="tenI CDS" gene 1123860..1124477 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /label="tenI gene" CDS 1124461..1125570 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /EC_number="1.4.3.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9827558, 11744710, 12627963, 15105420, 19751796, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9827558, 11744710, 12627963, 15105420, 19751796, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="FAD-dependent glycine oxidase" /protein_id="NP_389049.1" /db_xref="EnsemblGenomes-Gn:BSU11670" /db_xref="EnsemblGenomes-Tr:CAB13024" /db_xref="GOA:O31616" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR012727" /db_xref="InterPro:IPR036188" /db_xref="PDB:1NG3" /db_xref="PDB:1NG4" /db_xref="PDB:1RYI" /db_xref="PDB:3IF9" /db_xref="SubtiList:BG13147" /db_xref="UniProtKB/Swiss-Prot:O31616" /translation="MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTS AAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSE EDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKA AKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNA FLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLE SVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILL APATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI*" /label="thiO CDS" gene 1124461..1125570 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /label="thiO gene" CDS 1125570..1125770 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 14567704, 14757766, 15489164, 22616866, 26443755; Product type c : carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier for synthesis of hydroxyethylthiazole phosphate" /protein_id="NP_389050.1" /db_xref="EnsemblGenomes-Gn:BSU11680" /db_xref="EnsemblGenomes-Tr:CAB13025" /db_xref="GOA:O31617" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010035" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="PDB:1TYG" /db_xref="SubtiList:BG13148" /db_xref="UniProtKB/Swiss-Prot:O31617" /translation="MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKE RYHEVELCDRDVIEIVHFVGGG*" /label="thiS CDS" gene 1125570..1125770 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /label="thiS gene" CDS 1125767..1126537 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /EC_number="2.8.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14567704, 14757766, 15489164, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14567704, 14757766, 15489164, 22938038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="hydroxyethylthiazole phosphate synthetase (thiamine biosynthesis)" /protein_id="NP_389051.1" /db_xref="EnsemblGenomes-Gn:BSU11690" /db_xref="EnsemblGenomes-Tr:CAB13026" /db_xref="GOA:O31618" /db_xref="InterPro:IPR008867" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033983" /db_xref="PDB:1TYG" /db_xref="PDB:1XM3" /db_xref="SubtiList:BG13149" /db_xref="UniProtKB/Swiss-Prot:O31618" /translation="MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAV RRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVI GCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGS GQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVK MARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV*" /label="thiG CDS" gene 1125767..1126537 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /label="thiG gene" CDS 1126534..1127544 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /EC_number="2.7.7.73" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14567704, 14757766, 15489164, 16388576, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14567704, 14757766, 15489164, 16388576, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate transferase and sulfur transferase (thiamine biosynthesis)" /protein_id="NP_389052.1" /db_xref="EnsemblGenomes-Gn:BSU11700" /db_xref="EnsemblGenomes-Tr:CAB13027" /db_xref="GOA:O31619" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13150" /db_xref="UniProtKB/Swiss-Prot:O31619" /translation="MTGRYSRQELFAPIGPSGQKKLKEARAVIIGAGALGTASAEMLV RAGVGSVKIADRDYVEWSNLQRQQLYTEDDVKKEMPKAAAAERRLRSINSDVDVTGLV MDVTAENIFELIRDASIIVDAADNFETRLIVNDAAVKEGIPFLYGACVGSYGLTFTVV PGSTPCLHCLLDALPIGGATCDTAGIISPAVLQVAVFQVTDALKLLTGEECEPVLRSF DLWKNERSEVRAASLKHDACPSCGTKDFPFLSYENQTKAAVLCGRNTVQIRSSITKEA DLEALAGQLRQAGLEVAANPYLISCRSDDMKMVLFRDGRALIHGTNDIARAKSIYHKW IG*" /label="thiF CDS" gene 1126534..1127544 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /label="thiF gene" CDS 1127563..1128378 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /EC_number="2.7.4.7" /EC_number="2.7.1.49" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14973012, 16952958, 17012797, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14973012, 16952958, 17012797, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase" /protein_id="NP_389053.1" /db_xref="EnsemblGenomes-Gn:BSU11710" /db_xref="EnsemblGenomes-Tr:CAB13028" /db_xref="GOA:O31620" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13151" /db_xref="UniProtKB/Swiss-Prot:O31620" /translation="MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQ NTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRV IVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAA LTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR*" /label="thiD CDS" gene 1127563..1128378 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /label="thiD gene" downshifts 1128352 /Source="Nicolas_upshifts" /id="D635" /incds=0 /nref=128 /ntot=172 /MaxReadThrough="3.33485" /MaxDrop="5.0154" /score="3.40314581" /energy="-14.8" /TU="U943" /idTUdmin="U943" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1128425..1128431 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1128444..1128463 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1128454 /Source="Nicolas_upshifts" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="upshifts" CDS 1128514..1129290 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /EC_number="1.3.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 15105103, 21185310, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 15105103, 21185310, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase" /protein_id="NP_389054.2" /db_xref="EnsemblGenomes-Gn:BSU11720" /db_xref="EnsemblGenomes-Tr:CAB13029" /db_xref="GOA:P54616" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR014358" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIF" /db_xref="PDB:3OIG" /db_xref="SubtiList:BG13152" /db_xref="UniProtKB/Swiss-Prot:P54616" /translation="MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGER LEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEE LVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNV MGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPL RRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR*" /label="fabI CDS" gene 1128514..1129290 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /label="fabI gene" downshifts 1129279 /Source="Nicolas_upshifts" /id="D636" /incds=0 /nref=229 /ntot=313 /MaxReadThrough="3.12901" /MaxDrop="6.64182" /score="33.5478109" /energy="-11.8" /TU="U944" /idTUdmin="U944" /TUdmin="-416" /isTUend="FALSE" /label="downshifts" SCAR 1129294..1129295 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_009" S_feature <1129295..1130355 /Source="Nicolas_S_feature" /locus_tag="new_1253669_1254769" /HighExp="S8, S6, S7, B36, S5, C30, BT, dia15, Diami, H2O2" /AntisenseName="yjcD" /AntisenseCor="-0.210610370451118" /AntisenseRegPval="-3.3" /CDS_PredictionProba="0.18426200000000001" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S425" CDS complement(1129299..1131578) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544244, 16014871, 17114254, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent DNA helicase (sporulationassociated)" /protein_id="NP_389064.3" /db_xref="EnsemblGenomes-Gn:BSU11820" /db_xref="EnsemblGenomes-Tr:CAB13039" /db_xref="GOA:O31626" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG13157" /db_xref="UniProtKB/Swiss-Prot:O31626" /translation="MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLL RLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSP AVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSG KTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGT FHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGF WKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLL EQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFIL DFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYP YDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQ SFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKA LAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLE KGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTV YVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTA NRSRFLYPLLQKARQPLHH*" /label="yjcD CDS" gene complement(1129299..1131578) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /label="yjcD gene" downshifts complement(1129317) /Source="Nicolas_upshifts" /id="D648" /incds=0 /nref=61 /ntot=171 /MaxReadThrough="2.59869" /MaxDrop="4.36061" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1131453..1131627) /Source="Nicolas_S_feature" /locus_tag="new_1255867_1256041_c" /HighExp="G180, G135, G150, H2O2, Paraq, Oxctl, LBGexp, dia15, dia0, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S426" promotor_-35 1131506..1131514 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1131525..1131543 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1131529..1131664 /Source="Nicolas_S_feature" /locus_tag="new_1255943_1256078" /HighExp="S4, S5, S3, S6, S7, S8, M9-stat, T4.0H, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S427" upshifts 1131529 /Source="Nicolas_upshifts" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1131615..1131634) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1131626) /Source="Nicolas_upshifts" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1131642..1131648 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1131650..1131654) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1131663..1131681 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1131666 /Source="Nicolas_upshifts" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1131695..1131949 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11976315, 23155385" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097706.1" /db_xref="EnsemblGenomes-Gn:BSU11839" /db_xref="EnsemblGenomes-Tr:CAX52596" /db_xref="UniProtKB/Swiss-Prot:C0H3Y9" /translation="MIYAGQIQNQQYAQYANRTIGHKQDYAGTEKISYVPFQRVYKEL EKQQENQTAAERKVNEMKRKRSLYKRLREKGMGTYINRYV*" /label="yjzE CDS" gene 1131695..1131949 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /label="yjzE gene" downshifts 1131925 /Source="Nicolas_upshifts" /id="D649" /incds=0 /nref=101 /ntot=248 /MaxReadThrough="3.69482" /MaxDrop="7.80206" /score="5.37568515" /energy="-6.1" /TU="U962" /idTUdmin="U960" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1132015) /Source="Nicolas_upshifts" /id="D650" /incds=0 /nref=78 /ntot=283 /MaxReadThrough="3.21062" /MaxDrop="7.8562" /score="-4.05705392" /energy="-6.1" /TU="U963" /idTUdmin="U963" /TUdmin="-36" /isTUend="FALSE" /label="downshifts" CDS complement(1132022..1132444) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389066.1" /db_xref="EnsemblGenomes-Gn:BSU11840" /db_xref="EnsemblGenomes-Tr:CAB13041" /db_xref="GOA:O31628" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1Q2Y" /db_xref="SubtiList:BG13159" /db_xref="UniProtKB/Swiss-Prot:O31628" /translation="MKAVIAKNEEQLKDAFYVREEVFVKEQNVPAEEEIDELENESEH IVVYDGEKPVGAGRWRMKDGYGKLERICVLKSHRSAGVGGIIMKALEKAAADGGASGF ILNAQTQAVPFYKKHGYRVLSEKEFLDAGIPHLQMMKD*" /label="yjcF CDS" gene complement(1132022..1132444) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /label="yjcF gene" CDS complement(1132448..1132963) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12466548, 16511078, 17012785, 18473364, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA ligase or phosphoesterase" /protein_id="NP_389067.1" /db_xref="EnsemblGenomes-Gn:BSU11850" /db_xref="EnsemblGenomes-Tr:CAB13042" /db_xref="GOA:O31629" /db_xref="InterPro:IPR009097" /db_xref="InterPro:IPR022932" /db_xref="PDB:2D4G" /db_xref="SubtiList:BG13160" /db_xref="UniProtKB/Swiss-Prot:O31629" /translation="MKYGIVLFPSKKLQDLANSYRKRYDPSYSLIPPHLTLRASFECA EEKADQLVSHLRNIAKESHPLVLKMTKYSSFAPVNNVIYIKAEPTEELKTLNEKLYTG VLAGEQEYNFVPHVTVGQNLSDDEHSDVLGQLKMQEVSHEEIVDRFHLLYQLENGSWT VYETFLLGRGE*" /label="yjcG CDS" gene complement(1132448..1132963) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /label="yjcG gene" CDS complement(1133000..1133722) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative stress-related hydrolase" /protein_id="NP_389068.1" /db_xref="EnsemblGenomes-Gn:BSU11860" /db_xref="EnsemblGenomes-Tr:CAB13043" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13161" /db_xref="UniProtKB/Swiss-Prot:O31630" /translation="MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQ DGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFI AHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHV LEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEP FDGDHKWTYWQPLITPALKKML*" /label="yjcH CDS" gene complement(1133000..1133722) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /label="yjcH gene" misc_feature complement(1133761..1133780) /Source="Nicolas_upshift_promotors" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1133782) /Source="Nicolas_upshifts" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1133831..1133838 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1133853..1133872 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1133857 /Source="Nicolas_upshifts" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1133890..1134010 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswA RNA" gene 1133890..1134010 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /label="mswA gene" downshifts 1134015 /Source="Nicolas_upshifts" /id="D651" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="7.71668" /MaxDrop="5.0477" /score="31.1477774" /energy="-15.2" /TU="U964" /idTUdmin="U962" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" CDS 1134078..1135199 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /EC_number="2.5.1.49" /EC_number="2.5.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-synthase and O-acetylhomoserine thiolyase" /protein_id="NP_389069.1" /db_xref="EnsemblGenomes-Gn:BSU11870" /db_xref="EnsemblGenomes-Tr:CAB13044" /db_xref="GOA:O31631" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13162" /db_xref="UniProtKB/Swiss-Prot:O31631" /translation="MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGF DYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGG TYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLG EEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLY PGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIA NGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE*" /label="metI CDS" gene 1134078..1135199 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /label="metI gene" CDS 1135192..1136364 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /EC_number="4.4.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 11948165, 15760717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 11948165, 15760717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-lyase" /protein_id="NP_389070.1" /db_xref="EnsemblGenomes-Gn:BSU11880" /db_xref="EnsemblGenomes-Tr:CAB13045" /db_xref="GOA:O31632" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13163" /db_xref="UniProtKB/Swiss-Prot:O31632" /translation="MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEF GAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDV YGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKA VVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDE ELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKR VYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESI LSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR*" /label="metC CDS" gene 1135192..1136364 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /label="metC gene" downshifts 1136347 /Source="Nicolas_upshifts" /id="D652" /incds=0 /nref=108 /ntot=205 /MaxReadThrough="4.73188" /MaxDrop="5.54268" /score="4.00424187" /energy="-9.2" /TU="U964" /idTUdmin="U964" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" misc_feature 1136381..1136399 /Source="Nicolas_upshift_promotors" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1136391 /Source="Nicolas_upshifts" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="upshifts" S_feature 1136392..1137921 /Source="Nicolas_S_feature" /locus_tag="new_1260806_1262335" /HighExp="MG 5, MG t5, MG 10, BMM, GM 25, MG 15, Glu, GM 15, GM 45, GM 10" /AntisenseName="yjcK" /AntisenseCor="0.123731990206979" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.671, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S428" CDS complement(1136397..1136942) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /EC_number="2.3.1.267" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2828880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal-protein-alanine N-acetyltransferase" /protein_id="NP_389071.1" /db_xref="EnsemblGenomes-Gn:BSU11890" /db_xref="EnsemblGenomes-Tr:CAB13046" /db_xref="GOA:O31633" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13164" /db_xref="UniProtKB/Swiss-Prot:O31633" /translation="MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYT VEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDK AHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNV KINGVWEDHQVLAILNPDDEQ*" /label="yjcK CDS" gene complement(1136397..1136942) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /label="yjcK gene" downshifts complement(1136418) /Source="Nicolas_upshifts" /id="D653" /incds=0 /nref=14 /ntot=127 /MaxReadThrough="0.4032" /MaxDrop="4.23858" /score="-7.12102596" /energy="-7.3" /TU="NA" /idTUdmin="U966" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1137012..1138202) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein; possibly aquaporin-related" /protein_id="NP_389072.1" /db_xref="EnsemblGenomes-Gn:BSU11900" /db_xref="EnsemblGenomes-Tr:CAB13047" /db_xref="GOA:O31634" /db_xref="InterPro:IPR008537" /db_xref="SubtiList:BG13165" /db_xref="UniProtKB/Swiss-Prot:O31634" /translation="MHSLISSDDVWVLWGFIAVWAAVSIGLEQRFKWASAVSGAIIAL AGAMVFTNVGVLPVESPVYDTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISS VGTVLGSILAFFLLKQHIPYLDKIGGMISASYIGGGVNFAAMAAKFETPGEYVSATVV ADNFMMALLFFILISIPALKWFQRHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDI AFNAGAAFALVAVSMKVSGYFKSIFSHPLLTGTLGDQYLVLTSLTVLIIFLFPRFFER LNGSQELGTFLIYLFFVVIGIPADLRLIVTNAPLILLFVFIIAISNLAVSLAAGKLFR VRLEEILLAVNATVGGPTTAAAMAIAKGWRELVAPIMLVGTLGYLIGNYVGTFMGNWF SSFL*" /label="yjcL CDS" gene complement(1137012..1138202) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /label="yjcL gene" promotor_-10 complement(1138228..1138247) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1138232) /Source="Nicolas_upshifts" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1138262..1138269) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1138296..1138303 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1138307 /Source="Nicolas_upshifts" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1138317..1138336 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-10" tRNA 1138375..1138447 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="valine tRNA (GAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val2 tRNA" gene 1138375..1138447 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /label="trnSL-Val2 gene" promotor_-10 complement(1138389..1138406) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1138403) /Source="Nicolas_upshifts" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1138427..1138433) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1138437 /Source="Nicolas_upshifts" /id="D654" /incds=0 /nref=17 /ntot=80 /MaxReadThrough="4.64061" /MaxDrop="5.10012" /score="20.8247903" /energy="-9.1" /TU="U967" /idTUdmin="U965" /TUdmin=550 /isTUend="FALSE" /label="downshifts" S_feature complement(1138462..1139197) /Source="Nicolas_S_feature" /locus_tag="new_1262876_1263611_c" /HighExp="M9-stat, Lbstat, M0t90, Pyr, T0.30H, M40t90, C30, S1, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S429" S_feature 1138482..1140130 /Source="Nicolas_S_feature" /locus_tag="new_1262896_1264544" /HighExp="Cold, C30, G135, G180, G150, Oxctl, Fru, HPh, Glu, UNK1" /AntisenseName="yjcM" /AntisenseCor="0.46809452811910301" /AntisenseRegPval="-15.3" /CDS_PredictionProba="0.27514300000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S430" downshifts complement(1138491) /Source="Nicolas_upshifts" /id="D655" /incds=0 /nref=29 /ntot=192 /MaxReadThrough="1.23936" /MaxDrop="3.57085" /score="-4.98447688" /energy="-7.9" /TU="NA" /idTUdmin="U970" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1139199..1139287) /Source="Nicolas_S_feature" /locus_tag="new_1263613_1263701_c" /HighExp="aero, HPh, M0t45, SMM, dia0, GM 150, Mal, M/G, Mt0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S431" downshifts complement(1139242) /Source="Nicolas_upshifts" /id="D656" /incds=0 /nref=34 /ntot=148 /MaxReadThrough="4.13737" /MaxDrop="4.5557" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-751" /isTUend="FALSE" /label="downshifts" CDS complement(1139288..1140517) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20011599" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389073.1" /db_xref="EnsemblGenomes-Gn:BSU11910" /db_xref="EnsemblGenomes-Tr:CAB13048" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG13166" /db_xref="UniProtKB/Swiss-Prot:O31635" /translation="MKKELLASLVLCLSLSPLVSTNEVFAATTNKETKENVSITNEIG YEKVKDMLEQQKYDFEHNTPLAHPKESKLTDSDEGVLLYSALSKVDKQKFHEFTYDID DVKTSEKNNKLIVEAYITRNFVFGVEKVTTSLGDNIKLEIPKTTSNKQSSQSTNTSNL SFSQVKNSSNQLNVIPLSNSSKQLNVTQLNNSSSTLQYENDEEYSSDVKLDEFLKKYK QEVKNDDKEEVKSEDKPVSMNFNAANSNQLTVTATSVKGYSGYAAMKYAEKYALKPNK NYKYYKDKDCTNFVSQALRAGRMPYFKEWKPYTDAWVNAGAFRSYILKAGGIKMKTVS DTYSNVKLGDVYHYDYHNKIGLRYADGWMDHTAIVTSRANMKLYVSYHSTNRLNVPRE YVTSKEGGKRYVSSIRN*" /label="yjcM CDS" gene complement(1139288..1140517) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /label="yjcM gene" downshifts complement(1139410) /Source="Nicolas_upshifts" /id="D657" /incds=1 /nref=4 /ntot=143 /MaxReadThrough="5.58558" /MaxDrop="3.45178" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-919" /isTUend="FALSE" /label="downshifts" downshifts 1140087 /Source="Nicolas_upshifts" /id="D658" /incds=1 /nref=1 /ntot=48 /MaxReadThrough="3.19343" /MaxDrop="1.98614" /score="26.2462772" /energy="-24.7" /TU="NA" /idTUdmin="U967" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1140518..1140603) /Source="Nicolas_S_feature" /locus_tag="new_1264932_1265017_c" /HighExp="aero, SMM, T-3.40H, MG 150, Lbexp, SMMPr, GM 90, C90, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S432" promotor_-35 1140558..1140565 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1140580..1140599 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1140589..1140608) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1140593 /Source="Nicolas_upshifts" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1140607) /Source="Nicolas_upshifts" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1140621..1140627) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1140643..1140963 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389074.1" /db_xref="EnsemblGenomes-Gn:BSU11920" /db_xref="EnsemblGenomes-Tr:CAB13049" /db_xref="SubtiList:BG13167" /db_xref="UniProtKB/Swiss-Prot:O31636" /translation="MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIY KRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSC GTGP*" /label="yjcN CDS" gene 1140643..1140963 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /label="yjcN gene" downshifts 1140973 /Source="Nicolas_upshifts" /id="D659" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="3.73892" /MaxDrop="4.41989" /score="26.2462772" /energy="-24.7" /TU="U969" /idTUdmin="U967" /TUdmin=886 /isTUend="FALSE" /label="downshifts" S_feature 1141018..1141115 /Source="Nicolas_S_feature" /locus_tag="new_1265432_1265529" /HighExp="LoTm, B60, Cold, B36, T3.30H, T3.0H, T4.0H, T2.0H, Sw, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S433" CDS 1141116..1141247 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097707.1" /db_xref="EnsemblGenomes-Gn:BSU11928" /db_xref="EnsemblGenomes-Tr:CAX52597" /db_xref="UniProtKB/Swiss-Prot:C0H3Z0" /translation="MKQSKKKPSQKQHERLDRFWQQMMNTNMQTLRRGKGGAYKRRK* " /label="yjzF CDS" gene 1141116..1141247 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /label="yjzF gene" CDS 1141263..1141436 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097708.1" /db_xref="EnsemblGenomes-Gn:BSU11929" /db_xref="EnsemblGenomes-Tr:CAX52598" /db_xref="UniProtKB/Swiss-Prot:C0H3Z1" /translation="MMKNGFAYKNGKLVNIFCGKEELYNELKAFLVKTFSINVKEVSR PSIYRRTKSKQLE*" /label="yjzG CDS" gene 1141263..1141436 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /label="yjzG gene" CDS 1141473..1141934 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative DNA binding protein; phage island" /protein_id="NP_389075.1" /db_xref="EnsemblGenomes-Gn:BSU11930" /db_xref="EnsemblGenomes-Tr:CAB13050" /db_xref="GOA:O31637" /db_xref="InterPro:IPR013324" /db_xref="SubtiList:BG13168" /db_xref="UniProtKB/Swiss-Prot:O31637" /translation="MTDQMIAWEIEEWIRDYKFMLREIKRLNRVLNKVDFISTKLTAT YGEEAGMPRGSAGVSQAELRQMDRRERRLHKYESIVHYLDNAMEHIEEEKHRIVYDCM MEGMSYTAIANHLDCSRDTIRKIKTAIIGNIVNKVKEANFLQYLNSFKSAV*" /label="yjcO CDS" gene 1141473..1141934 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /label="yjcO gene" promotor_-35 1141905..1141912 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-35" promotor_-10 1141927..1141946 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-10" S_feature 1141935..1142175 /Source="Nicolas_S_feature" /locus_tag="new_1266349_1266589" /HighExp="LoTm, B60, Cold, B36, Diami, S8, dia15, C30, dia5, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12525800000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S434" upshifts 1141935 /Source="Nicolas_upshifts" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="upshifts" promotor_-35 1142148..1142155 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1142169..1142187 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1142177 /Source="Nicolas_upshifts" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1142200..1142703 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein: phage island" /protein_id="NP_389076.1" /db_xref="EnsemblGenomes-Gn:BSU11940" /db_xref="EnsemblGenomes-Tr:CAB13051" /db_xref="GOA:O31638" /db_xref="SubtiList:BG13169" /db_xref="UniProtKB/Swiss-Prot:O31638" /translation="MKKQKNNKKKNIEKRNIEKRNIEEKNNEDLEELENAIYTYHKKE LLAFFLEKTRIGHDKEEYKRFQSLLYKLDIECLEFAISRFSHIDIIHDHSKYVPAFIP LFAAYLTMFFNFYEKHWGALSFAAGTIAAIVWIIAVERKHRNQAISIMKIFEQVKERK VKDRSKD*" /label="yjcP CDS" gene 1142200..1142703 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /label="yjcP gene" CDS 1142715..1142999 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389077.1" /db_xref="EnsemblGenomes-Gn:BSU11950" /db_xref="EnsemblGenomes-Tr:CAB13052" /db_xref="InterPro:IPR018597" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HGC" /db_xref="SubtiList:BG13170" /db_xref="UniProtKB/Swiss-Prot:O31639" /translation="MNKDKLRYAILKEIFEGNTPLSENDIGVTEDQFDDAVNFLKREG YIIGVHYSDDRPHLYKLGPELTEKGENYLKENGTWSKAYKTIKEIKDWIK*" /label="yjcQ CDS" gene 1142715..1142999 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /label="yjcQ gene" downshifts 1142969 /Source="Nicolas_upshifts" /id="D660" /incds=0 /nref=215 /ntot=271 /MaxReadThrough="1.63272" /MaxDrop="7.26386" /score="22.0381158" /energy="-7.2" /TU="NA" /idTUdmin="U969" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1143001) /Source="Nicolas_upshifts" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1143012..1143015) /Source="Nicolas_upshift_promotors" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1143160..1143687 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7489895, 7704261; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage-related nucleic acid binding terminase small subunit; phage island" /protein_id="NP_389078.1" /db_xref="EnsemblGenomes-Gn:BSU11960" /db_xref="EnsemblGenomes-Tr:CAB13053" /db_xref="GOA:O31640" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010332" /db_xref="SubtiList:BG13171" /db_xref="UniProtKB/Swiss-Prot:O31640" /translation="MAEKHIQAYKDYVKGMKYKDLAEKYGVSVNTIKSWKQRHGWERK KGAPIEKSVHTKKGGQPGNKNALGNNGGAPQKNQNAVTHGFFSKFLPEETLEIMEEIQ ERSPADMIWDQIQIQYAAILRAQKIMFVSDKEEMIKELKKKRSLISEVSEIEDGLVIS FSTWFRYRLYSETNT*" /label="yjcR CDS" gene 1143160..1143687 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /label="yjcR gene" promotor_-35 1143834..1143839 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1143852..1143871 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1143855 /Source="Nicolas_upshifts" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="upshifts" CDS 1143861..1144178 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389079.1" /db_xref="EnsemblGenomes-Gn:BSU11970" /db_xref="EnsemblGenomes-Tr:CAB13054" /db_xref="GOA:O31641" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:1Q8B" /db_xref="SubtiList:BG13172" /db_xref="UniProtKB/Swiss-Prot:O31641" /translation="MKSHKMMGGGISMHYITACLKIISDKDLNEIMKEFKKLEEETNK EEGCITFHAYPLEPSERKIMLWEIWENEEAVKIHFTKKHTIDVQKQELTEVEWLMKSN VND*" /label="yjcS CDS" gene 1143861..1144178 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /label="yjcS gene" S_feature 1144179..1144414 /Source="Nicolas_S_feature" /locus_tag="new_1268593_1268828" /HighExp="dia5, H2O2, dia15, dia0, Lbexp, Lbtran, C90, Oxctl, S1, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S435" CDS 1144415..1145170 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2243795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-carrier protein oxidoreductase; phage island" /protein_id="NP_389080.1" /db_xref="EnsemblGenomes-Gn:BSU11980" /db_xref="EnsemblGenomes-Tr:CAB13055" /db_xref="GOA:O31642" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13173" /db_xref="UniProtKB/Swiss-Prot:O31642" /translation="MSHSQEKIALITGASSQGDIGTAICRKLASQGIHIFFTHWNSDT AWIEEFQQEILRMGVRCEAMKIDLSDAHAAFTIHEKISDKLGYPSILINNAAHSASDN YVSLDAKSLDEHYAVNMRSNFLLCVEFARRFKKSNLISGRIINMTSGQDLGPLPGELA YAATKGAISAFTRSLSQELAPLGITVNAVNPGPTDSTWMTDEIRNFLSPKFPMGRIGT PDDAARMIAFLASDEAEWITGQIIHSEGGFIRG*" /label="yjdA CDS" gene 1144415..1145170 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /label="yjdA gene" S_feature 1145171..1145258 /Source="Nicolas_S_feature" /locus_tag="new_1269585_1269672" /HighExp="C90, S1, dia0, dia5, Mt0, Lbexp, Gly, H2O2, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S436" downshifts 1145215 /Source="Nicolas_upshifts" /id="D661" /incds=0 /nref=89 /ntot=238 /MaxReadThrough="2.66489" /MaxDrop="5.39812" /score="-0.84766737" /energy="-14.2" /TU="NA" /idTUdmin="U974" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(1145258..1145318) /Source="Nicolas_S_feature" /locus_tag="new_1269672_1269732_c" /HighExp="Lbstat, BI, BT, nit, S2, ferm, B60, B36, M0t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S437" downshifts complement(1145289) /Source="Nicolas_upshifts" /id="D662" /incds=0 /nref=80 /ntot=134 /MaxReadThrough="1.9707" /MaxDrop="7.43843" /score="-5.56180712" /energy="-14.2" /TU="NA" /idTUdmin="U975" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1145319..1145666) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported protein; phage island" /protein_id="NP_389081.1" /db_xref="EnsemblGenomes-Gn:BSU11990" /db_xref="EnsemblGenomes-Tr:CAB13056" /db_xref="InterPro:IPR003343" /db_xref="InterPro:IPR008964" /db_xref="SubtiList:BG13174" /db_xref="UniProtKB/Swiss-Prot:O31643" /translation="MNFKKTVVSALSISALALSVSGVASAHEINSTPTEVKNISISPT HVIKIQDYNLPLKVGETYSVKNNSATRYWTDNQKVAEVDQNGLVTAKSKGKATITLFK GTAVFGKVYVTVY*" /label="yjdB CDS" gene complement(1145319..1145666) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /label="yjdB gene" promotor_-10 complement(1145698..1145716) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1145711) /Source="Nicolas_upshifts" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1145713..1146169) /Source="Nicolas_S_feature" /locus_tag="new_1270127_1270583_c" /HighExp="T1.30H, T2.0H, T2.30H, T3.0H, M9-stat, T1.0H, Lbstat, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S438" promotor_-35 complement(1145727..1145735) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1146129..1146147 /Source="Nicolas_upshift_promotors" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1146141 /Source="Nicolas_upshifts" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="upshifts" promotor_-10 complement(1146147..1146166) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1146169) /Source="Nicolas_upshifts" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1146180..1146187) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1146217..1148163 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10438772, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438772, 10960106, 23551403; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional DNA-binding activator" /protein_id="NP_389082.2" /db_xref="EnsemblGenomes-Gn:BSU12000" /db_xref="EnsemblGenomes-Tr:CAB13057" /db_xref="GOA:O31644" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG13175" /db_xref="UniProtKB/Swiss-Prot:O31644" /translation="MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLK VIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIA YDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNE RNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFES LLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAV YLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIH LNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTL HFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDY IKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQM LNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGI AIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLS EQPAFVQKLTKETNVMTFLSHLDY*" /label="manR CDS" gene 1146217..1148163 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /label="manR gene" downshifts 1148139 /Source="Nicolas_upshifts" /id="D663" /incds=0 /nref=3 /ntot=35 /MaxReadThrough="4.64475" /MaxDrop="3.79938" /score="28.4199725" /energy="-9.1" /TU="U976" /idTUdmin="U976" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" SCAR 1148193..1148194 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs02" S_feature <1148194..1148292 /Source="Nicolas_S_feature" /locus_tag="new_1275640_1275738" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, H2O2, dia5, Fru, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15168699999999999" /TUshortSig="SigA" /TUshortPSig="0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S439" promotor_-35 1148267..1148273 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1148288..1148307 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1148294..1148362 /Source="Nicolas_S_feature" /locus_tag="new_1275740_1275808" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, dia5, Fru, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S440" upshifts 1148294 /Source="Nicolas_upshifts" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="upshifts" CDS 1148363..1148845 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20139185" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389085.1" /db_xref="EnsemblGenomes-Gn:BSU12030" /db_xref="EnsemblGenomes-Tr:CAB13060" /db_xref="InterPro:IPR016787" /db_xref="SubtiList:BG13178" /db_xref="UniProtKB/Swiss-Prot:O31647" /translation="MSVTFPSSGCPSFFNIFYEEGIVMKLTIYYDGQFWVGVVEVVDN GKLRAFRHLFGKEPRDSEVLEFVHNQLLNMMAQAEQEGVRLQGRRQKKINPKRLQRQV SKELKNAGVTSKAQEAIKLELEARKQKKKQIMKEQREHVKEQRYMLKKQKAKKKHRGK *" /label="yjdF CDS" gene 1148363..1148845 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /label="yjdF gene" downshifts 1148825 /Source="Nicolas_upshifts" /id="D664" /incds=0 /nref=220 /ntot=267 /MaxReadThrough="5.32805" /MaxDrop="7.35641" /score="7.68574519" /energy="-10.2" /TU="U978" /idTUdmin="U980" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1148891..1149397) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389086.1" /db_xref="EnsemblGenomes-Gn:BSU12040" /db_xref="EnsemblGenomes-Tr:CAB13061" /db_xref="GOA:O31648" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13179" /db_xref="UniProtKB/Swiss-Prot:O31648" /translation="MVLLETNRLRLQTIDIPLLDAASKQDHQAIKELGYETNGEWPNS DFFEAIPYFREILVKNNGTKGFDSWIIVKKDNYEIVGGTGFLGDPDENGMIEIGFATN KSHRRKGYCVEAAQKLINWALSRETVSRITARCEHDNLGSQKTLEKLGFILNHKSAEY KHWIYVTK*" /label="yjdG CDS" gene complement(1148891..1149397) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /label="yjdG gene" downshifts complement(1148915) /Source="Nicolas_upshifts" /id="D665" /incds=0 /nref=13 /ntot=154 /MaxReadThrough="2.51872" /MaxDrop="4.09551" /score="15.8830125" /energy="-9.9" /TU="NA" /idTUdmin="U984" /TUdmin=7 /isTUend="TRUE" /label="downshifts" misc_feature complement(1149422..1149441) /Source="Nicolas_upshift_promotors" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1149428) /Source="Nicolas_upshifts" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1149430..1149615) /Source="Nicolas_S_feature" /locus_tag="new_1276876_1277061_c" /HighExp="S5, S4, S7, S6, S8, B36, LoTm, S3, B60, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.289238" /TUshortSig="SigEF, SigWXY" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S441" CDS complement(1149616..1150011) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389087.2" /db_xref="EnsemblGenomes-Gn:BSU12050" /db_xref="EnsemblGenomes-Tr:CAB13062" /db_xref="SubtiList:BG13180" /db_xref="UniProtKB/Swiss-Prot:O31649" /translation="MYHYFYGPALIPYFSHTHNPQRSPDFSERQRRREITLTVDGFVP PSSTEDLGDGFYSYAWTNQQVINPGEYLVCHLEGRDINVINGGFTPRDTAPLYAVASF PRRRNQWVIIIHNPVQTQRAISLYLIAKR*" /label="yjdH CDS" gene complement(1149616..1150011) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /label="yjdH gene" promotor_-10 complement(1150034..1150052) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1150047) /Source="Nicolas_upshifts" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1150049..1150749) /Source="Nicolas_S_feature" /locus_tag="new_1277495_1278195_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, S0, T2.0H, Salt, T2.30H, T-1.10H" /AntisenseName="yjdI" /AntisenseCor="-0.383915151906285" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S442" promotor_-35 complement(1150067..1150072) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1150155..1150162 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1150176..1150195 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1150187 /Source="Nicolas_upshifts" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="upshifts" CDS 1150240..1150719 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22128149; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cys-tRNApro deacetylase; tRNA editing" /protein_id="NP_389088.1" /db_xref="EnsemblGenomes-Gn:BSU12060" /db_xref="EnsemblGenomes-Tr:CAB13063" /db_xref="GOA:O31650" /db_xref="InterPro:IPR004369" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG13181" /db_xref="UniProtKB/Swiss-Prot:O31650" /translation="MAKKMAKTNAVRLIEQQNISYEVLGYKTDGQPVDGISVAEKIGY SLKYVYKTLVAAAGTNHYYVFVVPVAEELDVKKAAKVTGEKKIEMIAMKELLAVTGYL RGGCSPIGMKKLFPTYIDASAETLDFIIVSAGKIGMQLKLAPQDLARSCDAAFAEIV* " /label="trnE CDS" gene 1150240..1150719 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /label="trnE gene" downshifts 1150718 /Source="Nicolas_upshifts" /id="D666" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="2.68858" /MaxDrop="3.19616" /score="-5.52314972" /energy="-12.5" /TU="NA" /idTUdmin="U978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1150759..1150953) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097709.1" /db_xref="EnsemblGenomes-Gn:BSU12069" /db_xref="EnsemblGenomes-Tr:CAX52599" /db_xref="InterPro:IPR025234" /db_xref="UniProtKB/Swiss-Prot:C0H3Z2" /translation="MKEYEFVRVELSTMRRRPKEDYQQIIHDYAKRGWRFVQIFAPSI DGYGAAAYFEIIFERDAEKA*" /label="yjzH CDS" gene complement(1150759..1150953) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /label="yjzH gene" downshifts complement(1150794) /Source="Nicolas_upshifts" /id="D667" /incds=0 /nref=6 /ntot=144 /MaxReadThrough="7.83072" /MaxDrop="2.95935" /score="-6.07514027" /energy="-7" /TU="U984" /idTUdmin="U987" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1150967..1150982) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1150983) /Source="Nicolas_upshifts" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1150994..1151003) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1151119..1151448) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389089.1" /db_xref="EnsemblGenomes-Gn:BSU12070" /db_xref="EnsemblGenomes-Tr:CAB13064" /db_xref="GOA:O31651" /db_xref="InterPro:IPR016508" /db_xref="InterPro:IPR025440" /db_xref="SubtiList:BG13182" /db_xref="UniProtKB/Swiss-Prot:O31651" /translation="MKGIFLVVQLGFSIMVFLFLAAVNWYQGSELVSDRFDWNYTAKL SKLLNGIDAVSSPKQISQLDFFIYSAKHYPVMSALMIISFLYVLAALFLLIYSVKCNK QEIHLDC*" /label="yjdJ CDS" gene complement(1151119..1151448) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /label="yjdJ gene" promotor_-10 complement(1151485..1151504) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1151498) /Source="Nicolas_upshifts" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1151500..1152067) /Source="Nicolas_S_feature" /locus_tag="new_1278946_1279513_c" /HighExp="S8, S6, nit, S7, ferm, S2, S5, M9-tran, M/G, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S443" promotor_-35 complement(1151519..1151524) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1151552..1151556 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1151572..1151591 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1151576..1152077 /Source="Nicolas_S_feature" /locus_tag="new_1279022_1279523" /HighExp="LBGstat, C30, HPh, Oxctl, dia15, Paraq, T0.30H, C90, LBGtran, LPh" /AntisenseName="ctaO" /AntisenseCor="-0.43946575370083102" /AntisenseRegPval="-13.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S444" upshifts 1151576 /Source="Nicolas_upshifts" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1152068..1153057) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10675592, 15491161, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10675592, 15491161, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor protoheme IX farnesyltransferase 1 (heme Osynthase)" /protein_id="NP_389090.2" /db_xref="EnsemblGenomes-Gn:BSU12080" /db_xref="EnsemblGenomes-Tr:CAB13065" /db_xref="GOA:O31652" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG13183" /db_xref="UniProtKB/Swiss-Prot:O31652" /translation="MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGI IISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMD AKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGI RRKEEYRAAGVPLLPVVKGNHVTKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAA LVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMIDSFMMFLIR*" /label="ctaO CDS" gene complement(1152068..1153057) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /label="ctaO gene" promotor_-10 complement(1153058..1153077) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-10" upshifts complement(1153061) /Source="Nicolas_upshifts" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="upshifts" promotor_-35 complement(1153091..1153096) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-35" CDS complement(1153180..1153428) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1391045, 1917883, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1391045, 1917883, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner coat)" /protein_id="NP_389091.2" /db_xref="EnsemblGenomes-Gn:BSU12090" /db_xref="EnsemblGenomes-Tr:CAB13066" /db_xref="GOA:P11863" /db_xref="SubtiList:BG10495" /db_xref="UniProtKB/Swiss-Prot:P11863" /translation="MDYPLNEQSFEQITPYDERQPYYYPRPRPPFYPPYYYPRPYYPF YPFYPRPPYYYPRPRPPYYPWYGYGGGYGGGYGGGYGY*" /label="cotT CDS" gene complement(1153180..1153428) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /label="cotT gene" downshifts complement(1153190) /Source="Nicolas_upshifts" /id="D668" /incds=0 /nref=37 /ntot=82 /MaxReadThrough="5.73194" /MaxDrop="6.23577" /score="25.0951218" /energy="-8.4" /TU="U989" /idTUdmin="U990" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1153424..1153428 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1153437..1153451 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1153446 /Source="Nicolas_upshifts" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1153453..1153472) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1153462) /Source="Nicolas_upshifts" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1153486..1153495) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1153543..1153550 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1153557..1153576) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1153564..1153583 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1153566) /Source="Nicolas_upshifts" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="upshifts" upshifts 1153577 /Source="Nicolas_upshifts" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1153578..1153681 /Source="Nicolas_S_feature" /locus_tag="new_1281024_1281127" /HighExp="Heat, T0.30H, T1.0H, ferm, Diami, dia5, T1.30H, M9-stat, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S445" promotor_-35 complement(1153590..1153597) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1153682..1155085 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 17878218, 22277649" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 17878218, 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid deacetylase" /protein_id="NP_389092.1" /db_xref="EnsemblGenomes-Gn:BSU12100" /db_xref="EnsemblGenomes-Tr:CAB13067" /db_xref="GOA:O34798" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR017219" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="SubtiList:BG13184" /db_xref="UniProtKB/Swiss-Prot:O34798" /translation="MLAKRIKWFHVLIAVVCVVGLIGFFHNHSLKKETVMNKVRTDSQ YGNVEIATLVNDGKTFNYAVNYPVFKNEKMDSALKRFAEKEVRQFQKETKDVDQEHTT KRNELNVDYKIVHYAKQTVAIVFNEYKYIGGAHGQTVKKTFNYDFSKQAFLSIDDIFK EDADYLHKLSLIAYHELKKNKDIAADDALLKEGTAPKKENFSRFAIKEDYIELYFDTY QVAAGYLGEQSIAIKKSLLKDILKEQYIDKAKNKNKIKEQKPKHEVISLPKEETVDPN QKVIALTFDDGPNPATTNQILDSLKKYKGHATFFVLGSRVQYYPETLIRMLKEGNEVG NHSWSHPLLTRLSVKEALKQINDTQDIIEKISGYRPTLVRPPYGGINDELRSQMKMDV ALWDVDPEDWKDRNKKTIVDRVMNQAGDGRTILIHDIYRTSADAADEIIKKLTDQGYQ LVTVSQLEEVKKQREAK*" /label="pdaC CDS" gene 1153682..1155085 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /label="pdaC gene" downshifts 1155074 /Source="Nicolas_upshifts" /id="D669" /incds=0 /nref=173 /ntot=238 /MaxReadThrough="1.38483" /MaxDrop="6.60322" /score="39.935002" /energy="-13.8" /TU="NA" /idTUdmin="U991" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1155125..1155598) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389093.1" /db_xref="EnsemblGenomes-Gn:BSU12110" /db_xref="EnsemblGenomes-Tr:CAB13068" /db_xref="InterPro:IPR021224" /db_xref="SubtiList:BG13185" /db_xref="UniProtKB/Swiss-Prot:O34554" /translation="MKRLFMKASLVLFAVVFVFAVKGAPAKAETHAYDGKSPYYNDCA SSGSTKKSSNLVNASNQVIGVVELKFSSTCKTAWAKITMNNTLTSGYEANAEITRNTD GKRYNCDSAGGNGKAVAGQKSCYTPMVYDLDPRTSYAFGKYSGPNLNVWATTGSY*" /label="yjfA CDS" gene complement(1155125..1155598) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /label="yjfA gene" downshifts complement(1155129) /Source="Nicolas_upshifts" /id="D670" /incds=0 /nref=33 /ntot=176 /MaxReadThrough="2.25434" /MaxDrop="5.38548" /score="20.5383759" /energy="-13.8" /TU="NA" /idTUdmin="U992" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1155620..1155638) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1155638) /Source="Nicolas_upshifts" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1155653..1155658) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1155723..1155890) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389094.1" /db_xref="EnsemblGenomes-Gn:BSU12120" /db_xref="EnsemblGenomes-Tr:CAB13069" /db_xref="InterPro:IPR025906" /db_xref="SubtiList:BG13186" /db_xref="UniProtKB/Swiss-Prot:O34438" /translation="MDIPALSVAMHQASLAQNVNIALTKKRLDTAQQNADQTLKMIQH PTLGQTIDVKA*" /label="yjfB CDS" gene complement(1155723..1155890) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /label="yjfB gene" downshifts complement(1155726) /Source="Nicolas_upshifts" /id="D671" /incds=0 /nref=109 /ntot=232 /MaxReadThrough="3.53249" /MaxDrop="4.93218" /score="-9.08395816" /energy="-13.9" /TU="U993" /idTUdmin="U993" /TUdmin="-576" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1155902..1155920) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1155911) /Source="Nicolas_upshifts" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1155933..1155940) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1156017..1156916 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389095.2" /db_xref="EnsemblGenomes-Gn:BSU12130" /db_xref="EnsemblGenomes-Tr:CAB13070" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13187" /db_xref="UniProtKB/Swiss-Prot:O34458" /translation="MNLVMEKTFEQYEKLFSMEEQKREDVFRYTMMRPFEKMWTAIQV PLKAKEPNGYDVIMAAKMLGYLDVRDAESGQKALQILKESHVSETAESALRQCIFFAE REQLRVNAKEIKFGLYIADPNKLQLQKGYCGFGGIPGFIHVWINPNSYNLPRIPSIIA HEFHHNVRFSYIDFHHGSVSVGDYLVIEGLAESFARELFGTERLGPWVTRFDHEDLQY SIDVINEVLDVKGFSEVSRYMFGDPIANDQGFKPAGLSAFAGYAVGYHAVQSFMNQHH ITISEATRLDAKTIISQCGLFST*" /label="yjfC CDS" gene 1156017..1156916 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /label="yjfC gene" CDS complement(1156925..1157323) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_389096.1" /db_xref="EnsemblGenomes-Gn:BSU12140" /db_xref="EnsemblGenomes-Tr:CAB13071" /db_xref="GOA:O35027" /db_xref="InterPro:IPR021257" /db_xref="SubtiList:BG13188" /db_xref="UniProtKB/Swiss-Prot:O35027" /translation="MKRNRWIYAVFTILIIGLGLGSRAFSSVLPDTLNTYLGDSLWAA MIFTGCGFLFRKLKTMITGIISLSFCFVIEFSQLYHAEWIDQIRDTSLGGLVLGYGFL WSDIEAYTIGIAACAAIELLVLGIKKRRCM*" /label="yjgA CDS" gene complement(1156925..1157323) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /label="yjgA gene" downshifts complement(1156955) /Source="Nicolas_upshifts" /id="D672" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.86089" /MaxDrop="2.52307" /score="23.8106216" /energy="-10.1" /TU="U994,U995" /idTUdmin="U995" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1157352..1157371) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1157371) /Source="Nicolas_upshifts" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1157386..1157393) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1157424..1157999) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1580552" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389097.1" /db_xref="EnsemblGenomes-Gn:BSU12150" /db_xref="EnsemblGenomes-Tr:CAB13072" /db_xref="InterPro:IPR025453" /db_xref="PDB:4YGT" /db_xref="SubtiList:BG13189" /db_xref="UniProtKB/Swiss-Prot:O34960" /translation="MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTN QSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHW NMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTD EIDYVYDTGRYELHFVIGTDQTADHVNLKAK*" /label="yjgB CDS" gene complement(1157424..1157999) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /label="yjgB gene" downshifts complement(1157439) /Source="Nicolas_upshifts" /id="D673" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.38565" /MaxDrop="3.9021" /score="23.8106216" /energy="-10.1" /TU="U995" /idTUdmin="U995" /TUdmin="-727" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1158018..1158036) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1158033) /Source="Nicolas_upshifts" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1158050..1158056) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1158074..1158080 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1158095..1158113 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1158096 /Source="Nicolas_upshifts" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="upshifts" CDS 1158145..1161102 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /EC_number="1.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdoenzyme; putative formate dehydrogenase" /protein_id="NP_389098.1" /db_xref="EnsemblGenomes-Gn:BSU12160" /db_xref="EnsemblGenomes-Tr:CAB13073" /db_xref="GOA:O34720" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG13190" /db_xref="UniProtKB/Swiss-Prot:O34720" /translation="MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGP IETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVC DYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQD VQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYL TGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDV WTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEE ALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQ SPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKV IVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYV KSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISN LLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGV PLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIF LSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKL GAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPF PDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEI SPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGS HADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIF PGDAVKRGMGHNG*" /label="yjgC CDS" gene 1158145..1161102 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /label="yjgC gene" CDS 1161095..1161655 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389099.1" /db_xref="EnsemblGenomes-Gn:BSU12170" /db_xref="EnsemblGenomes-Tr:CAB13074" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13191" /db_xref="UniProtKB/Swiss-Prot:O34681" /translation="MAKAIKRIQKIEVTEEDQRKRDLREIEDALIDHKEAILETLHML GHMNERGVLPLLRGLFGQGDKVLDILVKKADTEETANTLKNLLLLFGTLGMLDVKQLE PLILKVNAGVASAVEQKNSEEKTGYFDIIRSLKDPEINKSITLLFSFLKGMGQDTKEL ERTTQPPEHQKHHQEPREKRGMNKRD*" /label="yjgD CDS" gene 1161095..1161655 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /label="yjgD gene" downshifts 1161648 /Source="Nicolas_upshifts" /id="D674" /incds=0 /nref=18 /ntot=84 /MaxReadThrough="5.25706" /MaxDrop="6.46184" /score="20.7921843" /energy="-15" /TU="U996" /idTUdmin="U996" /TUdmin="-819" /isTUend="FALSE" /label="downshifts" S_feature 1161693..1161811 /Source="Nicolas_S_feature" /locus_tag="new_1289139_1289257" /HighExp="Etha, Salt, Heat, S8, M9-stat, S7, LPhT, G135, C30, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S446" promotor_-35 1161789..1161792 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1161808..1161827 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1161813 /Source="Nicolas_upshifts" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1161852..1162493 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389100.1" /db_xref="EnsemblGenomes-Gn:BSU12180" /db_xref="EnsemblGenomes-Tr:CAB13075" /db_xref="GOA:O34725" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="PDB:3CFU" /db_xref="SubtiList:BG13192" /db_xref="UniProtKB/Swiss-Prot:O34725" /translation="MKKVLLLLFVLTIGLALSACSQSSDASEKEKPKEKKSQEELEKE LDKELKKGGEPKTKKDDQIHKIGETFKAGHTNFTVNKVDRVQKGEYMNVGGAVNEETK TIKDDEERLIIEVTMENIGEDSISYNFIGFDLRDKNDQSVRPVFSIEEKGRILMGGTL VSGKKVTGVLSYVIPKGEQKHYTLVYNPFLADTNSSNTEERVKDDIDYLVKLD*" /label="yjhA CDS" gene 1161852..1162493 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /label="yjhA gene" downshifts complement(1161861) /Source="Nicolas_upshifts" /id="D675" /incds=0 /nref=7 /ntot=57 /MaxReadThrough="2.5769" /MaxDrop="3.81596" /score="-9.34186213" /energy="-3" /TU="NA" /idTUdmin="U998" /TUdmin=1386 /isTUend="FALSE" /label="downshifts" downshifts 1162466 /Source="Nicolas_upshifts" /id="D676" /incds=0 /nref=24 /ntot=186 /MaxReadThrough="4.29897" /MaxDrop="3.4683" /score="19.6571267" /energy="-17" /TU="U997" /idTUdmin="U996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 1162572..1163198 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /EC_number="3.6.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12483591, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ADP-ribose pyrophosphatase" /protein_id="NP_389101.2" /db_xref="EnsemblGenomes-Gn:BSU12190" /db_xref="EnsemblGenomes-Tr:CAB13076" /db_xref="GOA:C0SPC3" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG13193" /db_xref="UniProtKB/Swiss-Prot:C0SPC3" /translation="MIKVQTKWLERAQRIRAIAQAGLAFSKDVYDRERYEELMKLSAE MMADYSEKDIEVITDLWQGEKGYPTPKADVRGAVFRENQILLVREKHDELWSLPGGFC EIGLSPAENVVKEIKEESGYDTEPSRLLAVLDSHKHSHPPQPYHYYKIFIACSMTDGQ GETGIETNHAAFFPEDRLPPLSPKRNTPSQLSMLFDFLRHPDKKTIFD*" /label="yjhB CDS" gene 1162572..1163198 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /label="yjhB gene" downshifts 1163200 /Source="Nicolas_upshifts" /id="D677" /incds=0 /nref=97 /ntot=202 /MaxReadThrough="0.597580000000001" /MaxDrop="6.62023" /score="12.2319602" /energy="-7" /TU="NA" /idTUdmin="U997" /TUdmin=7 /isTUend="TRUE" /label="downshifts" downshifts complement(1163203) /Source="Nicolas_upshifts" /id="D678" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.18907" /MaxDrop="3.31161" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(1163229..1163507) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 14563871" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389102.1" /db_xref="EnsemblGenomes-Gn:BSU12200" /db_xref="EnsemblGenomes-Tr:CAB13077" /db_xref="SubtiList:BG13194" /db_xref="UniProtKB/Swiss-Prot:O34679" /translation="MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENW HTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL*" /label="yjiA CDS" gene complement(1163229..1163507) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /label="yjiA gene" downshifts complement(1163247) /Source="Nicolas_upshifts" /id="D679" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="1.96302" /MaxDrop="5.98058" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1163536..1163547) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1163549..1163555) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1163555) /Source="Nicolas_upshifts" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1163557..1163973) /Source="Nicolas_S_feature" /locus_tag="new_1291003_1291419_c" /HighExp="S6, S7, S8, S5, BT, C30, Pyr, G/S, C90, B36" /AntisenseName="yjiB" /AntisenseCor="-0.25565388711625397" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S447" upshifts 1163725 /Source="Nicolas_upshifts" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1163726..1163745 /Source="Nicolas_upshift_promotors" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1163743..1163897 /Source="Nicolas_S_feature" /locus_tag="new_1291189_1291343" /HighExp="BC, T5.0H, T4.0H, C90, Sw, T3.30H, Lbstat, Diami, dia5, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.995811" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S448" CDS 1163898..1165088 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25587700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25587700; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP109B1, monooxygenase" /protein_id="NP_389103.1" /db_xref="EnsemblGenomes-Gn:BSU12210" /db_xref="EnsemblGenomes-Tr:CAB13078" /db_xref="GOA:O34374" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4RM4" /db_xref="SubtiList:BG13195" /db_xref="UniProtKB/Swiss-Prot:O34374" /translation="MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF RVKM*" /label="cypE CDS" gene 1163898..1165088 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /label="cypE gene" promotor_-10 complement(1163971..1163990) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1163973) /Source="Nicolas_upshifts" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1164004..1164013) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1165111..1166289 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 24893262, 27444326; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyphenols TDP-rhamnosyltransferase, promiscuous" /protein_id="NP_389104.1" /db_xref="EnsemblGenomes-Gn:BSU12220" /db_xref="EnsemblGenomes-Tr:CAB13079" /db_xref="GOA:O34539" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG13196" /db_xref="UniProtKB/Swiss-Prot:O34539" /translation="MKKYHISMINIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAP AVQQAGGEALIYHTSLNIDPKQIREMMEKNDAPLSLLKESLSILPQLEELYKDDQPDL IIYDFVALAGKLFAEKLNVPVIKLCSSYAQNESFQLGNEDMLKKIREAEAEFKAYLEQ EKLPAVSFEQLAVPEALNIVFMPKSFQIQHETFDDRFCFVGPSLGERKEKESLLIDKD DRPLMLISLGTAFNAWPEFYKMCIKAFRDSSWQVIMSVGKTIDPESLEDIPANFTIRQ SVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYL PKEEVTVSSLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKKSAVPQ *" /label="ppuG CDS" gene 1165111..1166289 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /label="ppuG gene" CDS complement(1166330..1166518) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="YP_003097710.1" /db_xref="EnsemblGenomes-Gn:BSU12229" /db_xref="EnsemblGenomes-Tr:CAX52600" /db_xref="UniProtKB/Swiss-Prot:C0H3Z3" /translation="METKKEEYETKGYDTSIVYEFNEYPDARSGRCDNCDYTLFKSSV KGGKFLRECRRCGMKKNI*" /label="yjzI CDS" gene complement(1166330..1166518) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /label="yjzI gene" downshifts complement(1166346) /Source="Nicolas_upshifts" /id="D680" /incds=0 /nref=94 /ntot=231 /MaxReadThrough="-0.1433" /MaxDrop="5.1712" /score="13.0160925" /energy="-9.5" /TU="NA" /idTUdmin="U1001" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1166544..1166563) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1166547) /Source="Nicolas_upshifts" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1166577..1166583) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1166605..1166612 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1166627..1166646 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1166638 /Source="Nicolas_upshifts" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1166653..1166672) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1166657) /Source="Nicolas_upshifts" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1166687..1166694) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1166692..1167504 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389105.1" /db_xref="EnsemblGenomes-Gn:BSU12230" /db_xref="EnsemblGenomes-Tr:CAB13080" /db_xref="GOA:O34394" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG13197" /db_xref="UniProtKB/Swiss-Prot:O34394" /translation="MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLA EKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYK TLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEV KKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE*" /label="yjjA CDS" gene 1166692..1167504 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /label="yjjA gene" downshifts 1167483 /Source="Nicolas_upshifts" /id="D681" /incds=0 /nref=196 /ntot=254 /MaxReadThrough="3.61369" /MaxDrop="5.73094" /score="10.6328997" /energy="-14.5" /TU="U1002" /idTUdmin="U1002" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1167550..1168302) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_389106.1" /db_xref="EnsemblGenomes-Gn:BSU12240" /db_xref="EnsemblGenomes-Tr:CAB13081" /db_xref="GOA:O34684" /db_xref="InterPro:IPR005226" /db_xref="SubtiList:BG13198" /db_xref="UniProtKB/Swiss-Prot:O34684" /translation="MDYLSLSLTMIFVLIALFLSKSFKAGVEKDMIIATIRAAVQLLI IGYVLSLIFRGDHPVFILLMVLLMLAVAAQNVIKRKKNTIGSFWRVFAALAIVEIVTQ GILLSLHIIPLTARYVIPISGMVIGNSMVLSSLFLNRLNSEVGVRKEEIQLILSLGGT PKQSIQRILTSAMKMSMIPTLESQKTLGLVQLPGMMTGQILAGADPIQAVRFQLLIVF TTMASAALTCVILSVLTYPSLFTVHQQLKQNE*" /label="yjkA CDS" gene complement(1167550..1168302) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /label="yjkA gene" downshifts complement(1167559) /Source="Nicolas_upshifts" /id="D682" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="0.924970000000001" /MaxDrop="3.5673" /score="13.1058081" /energy="-12.8" /TU="NA" /idTUdmin="U1001" /TUdmin="-1210" /isTUend="FALSE" /label="downshifts" CDS complement(1168302..1169054) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389107.1" /db_xref="EnsemblGenomes-Gn:BSU12250" /db_xref="EnsemblGenomes-Tr:CAB13082" /db_xref="GOA:O34756" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13199" /db_xref="UniProtKB/Swiss-Prot:O34756" /translation="MEANDQTQNIPAISFRSVRKSYKQDGQTYDVLQDVTGDIQQGAI VAVLGPSGSGKSTLLSMCNLMRTPDSGEVNIYGKEVREWNVNELRRTAALAFQSAPVL DGTVRDNLSLVQRLHQSQLYSPEKLASLAGLPPELLDRSARDLSGGQRQRLSLARTLS NPSSILLLDEITSALDPVSALEIEELIKRQHQEKKWTVMWVTHNMEQAKRIADTIWFM ADGRLLEIAETDTFFSAPQHEAAKEFLKGGTR*" /label="yjkB CDS" gene complement(1168302..1169054) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /label="yjkB gene" CDS complement(1169174..1170148) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14627822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389108.1" /db_xref="EnsemblGenomes-Gn:BSU12260" /db_xref="EnsemblGenomes-Tr:CAB13083" /db_xref="GOA:O34428" /db_xref="InterPro:IPR032713" /db_xref="SubtiList:BG13200" /db_xref="UniProtKB/Swiss-Prot:O34428" /translation="MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVP FLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQ ITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSG RMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWW SDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALL GEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA*" /label="yjlA CDS" gene complement(1169174..1170148) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /label="yjlA gene" downshifts complement(1169209) /Source="Nicolas_upshifts" /id="D683" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="1.84381" /MaxDrop="2.54799" /score="4.80318278" /energy="-14.5" /TU="NA" /idTUdmin="U1004" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1170169..1170188) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1170195) /Source="Nicolas_upshifts" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1170197..1172703) /Source="Nicolas_S_feature" /locus_tag="new_1297643_1300149_c" /HighExp="Lbstat, S2, M0t90, nit, BT, M40t90, ferm, BC, C30, Gly" /AntisenseName="ndh" /AntisenseCor="-0.74506751931257098" /AntisenseRegPval="-48.1" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S449" promotor_-35 complement(1170203..1170210) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1170231..1170237 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1170252..1170270 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1170255 /Source="Nicolas_upshifts" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1170280..1170777 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10704478" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; cupin family" /protein_id="NP_389109.1" /db_xref="EnsemblGenomes-Gn:BSU12270" /db_xref="EnsemblGenomes-Tr:CAB13084" /db_xref="GOA:O34612" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014500" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13201" /db_xref="UniProtKB/Swiss-Prot:O34612" /translation="MERETQTYFFPDDGRIPNHPDFPLVVYQNALKDTGLAERIVTRH GWSNSWSGSVFPYHHYHSNTHEVLIALRREAVIQFGGEKGAAIPFKSGDAVVIPAGVG HKKLSSSPDFTVLGAYPGGVQYDMKTGKPNEREEAVKQIKQAALPANDPITGKREPLL EIWVK*" /label="yjlB CDS" gene 1170280..1170777 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /label="yjlB gene" S_feature 1170778..1170891 /Source="Nicolas_S_feature" /locus_tag="new_1298224_1298337" /HighExp="Etha, M9-stat, B60, Salt, Gly, LPhT, Heat, Sw, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S450" promotor_-35 1170871..1170875 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1170891..1170910 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1170893..1171165 /Source="Nicolas_S_feature" /locus_tag="new_1298339_1298611" /HighExp="LBGtran, dia5, Lbexp, LBGexp, dia0, HPh, aero, LPh, BMM, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S451" upshifts 1170893 /Source="Nicolas_upshifts" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1171166..1171588 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16513748, 17015645, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389110.1" /db_xref="EnsemblGenomes-Gn:BSU12280" /db_xref="EnsemblGenomes-Tr:CAB13085" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13202" /db_xref="UniProtKB/Swiss-Prot:O34633" /translation="MPETIDQTNASVSQSQQDLIDQLLKPEVQESLTVLVDQLPKLTE LVNILTKSYDFAQSVATDEVLKSDTVGAITEILEPVKETAKEVAATAIEAKDRAEASN ETIGLFGLLRMLKDPQAQKLFRFANSYLEVMNERENQK*" /label="yjlC CDS" gene 1171166..1171588 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /label="yjlC gene" CDS 1171628..1172806 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /EC_number="1.6.99.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6816592, 16513748, 17015645, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6816592, 16513748, 17015645, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase" /protein_id="NP_389111.1" /db_xref="EnsemblGenomes-Gn:BSU12290" /db_xref="EnsemblGenomes-Tr:CAB13086" /db_xref="GOA:P80861" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13203" /db_xref="UniProtKB/Swiss-Prot:P80861" /translation="MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQII TELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDA LVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIG GGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASL EKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRA TVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTL ETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY *" /label="ndh CDS" gene 1171628..1172806 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /label="ndh gene" promotor_no_box 1172637..1172737 /Source="Nicolas_upshift_promotors" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1172695..1172713) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1172697 /Source="Nicolas_upshifts" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1172703) /Source="Nicolas_upshifts" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1172725..1172733) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1172805 /Source="Nicolas_upshifts" /id="D684" /incds=0 /nref=220 /ntot=278 /MaxReadThrough="2.01042" /MaxDrop="8.69373" /score="30.6421047" /energy="-23.1" /TU="NA" /idTUdmin="U1005" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 1172914..1172921 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1172936..1172955 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1172961 /Source="Nicolas_upshifts" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="upshifts" CDS 1173004..1174425 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /EC_number="5.3.1.12" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galacturonate isomerase" /protein_id="NP_389112.1" /db_xref="EnsemblGenomes-Gn:BSU12300" /db_xref="EnsemblGenomes-Tr:CAB13087" /db_xref="GOA:O34808" /db_xref="InterPro:IPR003766" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13204" /db_xref="UniProtKB/Swiss-Prot:O34808" /translation="MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYEN KTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYN WTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFL KALEKRVRFFHSAGGRVSDHAIDTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKT YTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLN SVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQ MKALSNVGLFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGS IVQGICYDNAKHYFQFQEEKANV*" /label="uxaC CDS" gene 1173004..1174425 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /label="uxaC gene" CDS 1174493..1175872 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+:altronate/mannonate symporter" /protein_id="NP_389113.1" /db_xref="EnsemblGenomes-Gn:BSU12310" /db_xref="EnsemblGenomes-Tr:CAB13088" /db_xref="GOA:O34961" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13205" /db_xref="UniProtKB/Swiss-Prot:O34961" /translation="MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYL LKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSSIDYRKNIGKRGKFRPYLLIGSI VLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKE RIIISEAPKEKLTLSSVVKTFITNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGN VELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVAADLINFMLPSNVYV FTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSG FLSGIGLGIIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQ IVQDLHQKS*" /label="exuM CDS" gene 1174493..1175872 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /label="exuM gene" promotor_-10 complement(1175012..1175031) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1175017) /Source="Nicolas_upshifts" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1175045..1175052) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1175897 /Source="Nicolas_upshifts" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1175907..1175914 /Source="Nicolas_upshift_promotors" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1175909..1175976 /Source="Nicolas_S_feature" /locus_tag="new_1303355_1303422" /HighExp="S4, S5, S6, S3, S8, S7, T5.0H, T4.0H, T3.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S452" CDS 1175977..1176990 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655, 16788182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389114.1" /db_xref="EnsemblGenomes-Gn:BSU12320" /db_xref="EnsemblGenomes-Tr:CAB13089" /db_xref="GOA:O34736" /db_xref="InterPro:IPR003767" /db_xref="InterPro:IPR036111" /db_xref="SubtiList:BG13206" /db_xref="UniProtKB/Swiss-Prot:O34736" /translation="MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNV HSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAID MAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTN PIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV SLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFF TDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL KSR*" /label="yjmC CDS" gene 1175977..1176990 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /label="yjmC gene" CDS 1176996..1178015 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389115.1" /db_xref="EnsemblGenomes-Gn:BSU12330" /db_xref="EnsemblGenomes-Tr:CAB13090" /db_xref="GOA:O35045" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13207" /db_xref="UniProtKB/Swiss-Prot:O35045" /translation="MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHI YHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPN VCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVE KGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVA ERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKK EVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKA VITFD*" /label="yjmD CDS" gene 1176996..1178015 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /label="yjmD gene" CDS 1178040..1179119 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /EC_number="4.2.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9579062, 9882655, 10368143, 25145794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-mannonate dehydratase" /protein_id="NP_389116.1" /db_xref="EnsemblGenomes-Gn:BSU12340" /db_xref="EnsemblGenomes-Tr:CAB13091" /db_xref="GOA:O34346" /db_xref="InterPro:IPR004628" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG13208" /db_xref="UniProtKB/Swiss-Prot:O34346" /translation="MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEK EEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVI CYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLP RIITGEASYKKLRAISDSPSNCITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVK IYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYD RALGIMYLNGLWDAYEAMAKKEVGI*" /label="uxuA CDS" gene 1178040..1179119 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /label="uxuA gene" CDS 1179116..1179952 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /EC_number="1.1.1.57" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructuronate reductase" /protein_id="NP_389117.1" /db_xref="EnsemblGenomes-Gn:BSU12350" /db_xref="EnsemblGenomes-Tr:CAB13092" /db_xref="GOA:O34896" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13209" /db_xref="UniProtKB/Swiss-Prot:O34896" /translation="MIPLHENLAGKTAVITGGSGVLCSAMARELARHGMKVAILNRTA EKGQAVVKEITAAGGTACAVAADVLDRMSLERAKEDILGQFGAVDLLINGAGGNHPDA ITDVETYEEAGEGQSFFDMDERGFLTVFSTNFTGAFLASQVFGKELLKADSPAIINLS SMSAYSPMTKVPAYSAAKASINNFTMWMAVHFAETGLRVNAIAPGFFLTKQNHDLLIN QDGTFTSRSHKIIAGTPMKRFGKPEDLLGTLLWLADESYSGFVTGITVPVDGGFMAYS GV*" /label="uxuB CDS" gene 1179116..1179952 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /label="uxuB gene" CDS 1180000..1181268 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8320243, 9579062, 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="hexuronate transporter" /protein_id="NP_389118.1" /db_xref="EnsemblGenomes-Gn:BSU12360" /db_xref="EnsemblGenomes-Tr:CAB13093" /db_xref="GOA:O34456" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13210" /db_xref="UniProtKB/Swiss-Prot:O34456" /translation="MFSKDKLPVILFLFLAGVINYLDRSALSIAAPFIQDDLTLSATQ MGLIFSSFSIGYAIFNFLGGVASDRYGAKLTLFVAMVVWSLFSGAVALAFGFVSLLII RILFGMGEGPLSATINKMVNNWFPPTQRASVIGVTNSGTPLGGAISGPIVGMIAVAFS WKVSFVLIMIIGLIWAVLWFKFVKEKPQETIKEAPAIKAETSPGEKIPLTFYLKQKTV LFTAFAFFAYNYILFFFLTWFPSYLVDERGLSVESMSVITVIPWILGFIGLAAGGFVS DYVYKKTARKGVLFSRKVVLVTCLFSSAVLIGFAGLVATTAGAVTLVALSVFFLYLTG AIYWAVIQDVVDQNNVGSVGGFMHFLANTAGIIGPALTGFIVDQTGTFSGAFLLAGGL AVFASLAVIRFVRPIIGKPAGTEAENPVSY*" /label="exuT CDS" gene 1180000..1181268 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /label="exuT gene" promotor_-35 1181212..1181215 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1181231..1181235 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1181233 /Source="Nicolas_upshifts" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1181301..1181320 /Source="Nicolas_upshift_promotors" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1181301 /Source="Nicolas_upshifts" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" CDS 1181356..1182357 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9579062, 9882655" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9579062, 9882655; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_389119.1" /db_xref="EnsemblGenomes-Gn:BSU12370" /db_xref="EnsemblGenomes-Tr:CAB13094" /db_xref="GOA:Q9JMQ1" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13211" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ1" /translation="MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLN YTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDD LKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDK EGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQY DMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGF SQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT* " /label="exuR CDS" gene 1181356..1182357 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /label="exuR gene" promotor_no_box complement(1182039..1182139) /Source="Nicolas_upshift_promotors" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1182079) /Source="Nicolas_upshifts" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1182333 /Source="Nicolas_upshifts" /id="D685" /incds=0 /nref=2 /ntot=132 /MaxReadThrough="2.47166" /MaxDrop="3.11543" /score="12.2153519" /energy="-7.4" /TU="NA" /idTUdmin="U1011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1182434..1183876 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /EC_number="1.1.1.58" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tagaturonate reductase (altronate oxidoreductase)" /protein_id="NP_389120.1" /db_xref="EnsemblGenomes-Gn:BSU12380" /db_xref="EnsemblGenomes-Tr:CAB13095" /db_xref="GOA:O34354" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023668" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13212" /db_xref="UniProtKB/Swiss-Prot:O34354" /translation="MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTD FNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDY EAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPG FPVDSIDEITADLGYQDDLIVVGEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTP YRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGL SQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFS ALLYFYHDNETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLT DRVAVYLNHIHELGMQRALEQYCIQGGEVR*" /label="uxaB CDS" gene 1182434..1183876 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /label="uxaB gene" CDS 1183873..1185366 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /EC_number="4.2.1.7" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="altronate dehydratase" /protein_id="NP_389121.2" /db_xref="EnsemblGenomes-Gn:BSU12390" /db_xref="EnsemblGenomes-Tr:CAB13096" /db_xref="GOA:O34673" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="SubtiList:BG13213" /db_xref="UniProtKB/Swiss-Prot:O34673" /translation="MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHK IALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPY SNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLK RVKFLESQSVTDEMEAGVALLKEIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITA NPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFHKIVDLINDFKQYFI KHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSA PGNDLIASSALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGL LAEDDVHEEYVLREFIHYMIEVASGQLVNHEKNDFKELAIFKSGVTL*" /label="uxaA CDS" gene 1183873..1185366 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /label="uxaA gene" CDS complement(1185405..1186169) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389122.1" /db_xref="EnsemblGenomes-Gn:BSU12400" /db_xref="EnsemblGenomes-Tr:CAB13097" /db_xref="GOA:O34578" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13214" /db_xref="UniProtKB/Swiss-Prot:O34578" /modified_by="User" /translation="MSVSIILMGLFVGALVGLTGVGGAALLTPLLIVLGINPSIAVGT DLVYNSITKLFGVASHWRQKTINFKLVKYLAIGGIPSASLAIGILHLFPAFHQHQEEI IKHALGYVLTLVAISIIVRLFLDRKLRPNRWQLMPLENKRALTILIGVVFGFIVGLTS IGSGSLFAIAMIYLFNMKASQIVGTDIAHAFLLVTAAGILNASFGSVDYMLAANLLLG SIPGVLIGSHLSPRFSPRPLQFIMASIILVSGLKLI*" /label="Delta6_BSU_12400_SNPvariant" gene complement(1185405..1186169) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /modified_by="User" /label="Delta6_BSU_12400_SNPvariant" downshifts complement(1185424) /Source="Nicolas_upshifts" /id="D686" /incds=0 /nref=96 /ntot=170 /MaxReadThrough="1.34004" /MaxDrop="4.60564" /score="6.47747687" /energy="-11.3" /TU="NA" /idTUdmin="U1015" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" Polymorphism join(1185937,1185939) /Source="geneious" /ID="SNP_BsDelta6_1313384_1313384" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="S -> G" /CDS_Position=232 /Change="T -> C" /Codon_Change="AGT -> GGT" /Coverage=150 /locus_tag="BSU_12400" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=149 /comment="Delta6_BSU_12400_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" SCAR join(1186196,1186203) /created_by="User" /modified_by="User" /label="TF8A" N_region 1186197..1186202 /created_by="User" /note_="EcoRI site (GAATTC)" /modified_by="User" /label="TF8A" CDS <1186205..1186525 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389164.1" /db_xref="EnsemblGenomes-Gn:BSU12810" /db_xref="EnsemblGenomes-Tr:CAB13138" /db_xref="GOA:P39800" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="PDB:3HMB" /db_xref="PDB:3RDR" /db_xref="SubtiList:BG10962" /db_xref="UniProtKB/Swiss-Prot:P39800" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /translation="PNLIRVGQVLIVSAPSAAEKPELYPLPDGIIQLTTPYTSGEHVF QVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVNGLTADGIYGPATKEKIA AQLS*" /label="Delta6_pseudo_BSU_12810" gene <1186205..1186525 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /label="Delta6_pseudo_BSU_12810" downshifts 1186534 /Source="Nicolas_upshifts" /id="D696" /incds=0 /nref=29 /ntot=162 /MaxReadThrough="3.77255" /MaxDrop="5.00305" /score="30.9009227" /energy="-12.5" /TU="U1029,U1033" /idTUdmin="U1029" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" S_feature complement(1186543..1186746) /Source="Nicolas_S_feature" /locus_tag="new_1348200_1348403_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.798" /TUlongSig="NA" /TUlongPSig="NA" /label="S458" CDS complement(1186562..1186699) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type r: regulator" /codon_start=1 /transl_table=11 /product="three component toxin / antitoxin / antitoxin SpoIISABC, antitoxin C" /protein_id="YP_009513952.1" /translation="MSGDTVKKLVRRVKFVDYGRFGLSGYSLRVRERSAGIIKKLKKK K*" /label="spoIISC CDS" gene complement(1186562..1186699) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /label="spoIISC gene" downshifts complement(1186586) /Source="Nicolas_upshifts" /id="D697" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="2.75573" /MaxDrop="4.3776" /score="24.0186344" /energy="-12.5" /TU="U1034" /idTUdmin="U1035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1186785..1186955) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptotic control system component B (antitoxin B)" /protein_id="NP_389165.1" /db_xref="EnsemblGenomes-Gn:BSU12820" /db_xref="EnsemblGenomes-Tr:CAB13139" /db_xref="GOA:O34800" /db_xref="InterPro:IPR025897" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12678" /db_xref="UniProtKB/Swiss-Prot:O34800" /translation="MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKEN ERLIDEYKRKKA*" /label="spoIISB CDS" gene complement(1186785..1186955) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /label="spoIISB gene" downshifts complement(1186791) /Source="Nicolas_upshifts" /id="D698" /incds=0 /nref=6 /ntot=86 /MaxReadThrough="4.69899" /MaxDrop="3.0872" /score="24.0186344" /energy="-12.5" /TU="U1034,U1035" /idTUdmin="U1035" /TUdmin="-205" /isTUend="FALSE" /label="downshifts" CDS complement(1186955..1187701) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptosis factor (ABC toxin/antitoxin/antitoxin system)" /protein_id="NP_389166.1" /db_xref="EnsemblGenomes-Gn:BSU12830" /db_xref="EnsemblGenomes-Tr:CAB13140" /db_xref="GOA:O34853" /db_xref="InterPro:IPR025940" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12677" /db_xref="UniProtKB/Swiss-Prot:O34853" /translation="MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLL FVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREI LEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSD SIVTEFDYLLFTSLTSIYDLVLPIEEEGEG*" /label="spoIISA CDS" gene complement(1186955..1187701) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /label="spoIISA gene" promotor_-10 complement(1187536..1187555) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1187553) /Source="Nicolas_upshifts" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1187571..1187578) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1187727..1187745) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1187740) /Source="Nicolas_upshifts" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1187761..1187766) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1187811..1188812) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10784039, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative low-affinity inorganic phosphate transporter" /protein_id="NP_389167.2" /db_xref="EnsemblGenomes-Gn:BSU12840" /db_xref="EnsemblGenomes-Tr:CAB13141" /db_xref="GOA:O34436" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13226" /db_xref="UniProtKB/Swiss-Prot:O34436" /translation="MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRH AIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYG IPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKL IFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIP TWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLP VSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF* " /label="pitB CDS" gene complement(1187811..1188812) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /label="pitB gene" downshifts complement(1187840) /Source="Nicolas_upshifts" /id="D699" /incds=0 /nref=205 /ntot=253 /MaxReadThrough="3.49591" /MaxDrop="5.81942" /score="21.8061263" /energy="-11" /TU="U1036,U1038" /idTUdmin="U1037" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1188825..1189442) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696772, 14563871; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PitB transporter accessory protein" /protein_id="NP_389168.1" /db_xref="EnsemblGenomes-Gn:BSU12850" /db_xref="EnsemblGenomes-Tr:CAB13142" /db_xref="InterPro:IPR018445" /db_xref="SubtiList:BG13225" /db_xref="UniProtKB/Swiss-Prot:O34454" /translation="MIRRKKDKFSLLLTEIAKNIDETAEYFVNFKVTNQTTLKEFADT LKEYETKGDNHVHVMIKELNKAFITPIEREDILQLTNSLDDVLDGIEHFSAMMEIFSI TSSDEHIDKFSGYIRECAKEILITIELLAENRLKDIQPHAIKIKEYEHSCDNLHRKSL KNLFGNETDPIKVIQYREIYETLEEIADSCQSVANNLETIIMKNA*" /label="ykaA CDS" gene complement(1188825..1189442) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /label="ykaA gene" promotor_-10 complement(1189478..1189497) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1189480) /Source="Nicolas_upshifts" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1189482..1189579) /Source="Nicolas_S_feature" /locus_tag="new_1351139_1351236_c" /HighExp="H2O2, Etha, dia15, Diami, Paraq, Heat, dia5, Salt, LBGstat, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.972, 0.987" /TUlongSig="SigA" /TUlongPSig="0.992" /label="S459" promotor_-35 complement(1189513..1189517) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1189559..1189578) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1189579) /Source="Nicolas_upshifts" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1189593..1189600) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1189624..1189643) /Source="Nicolas_upshift_promotors" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1189636) /Source="Nicolas_upshifts" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1189718..1191034) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17344220, 19419962, 20610400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17344220, 19419962, 20610400; Product type t : transporter" /codon_start=1 /transl_table=11 /product="serine / threonine exchanger" /protein_id="NP_389169.1" /db_xref="EnsemblGenomes-Gn:BSU12860" /db_xref="EnsemblGenomes-Tr:CAB13143" /db_xref="GOA:O34739" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG13227" /db_xref="UniProtKB/Swiss-Prot:O34739" /translation="MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDS KMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIY GPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEM KNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIG GKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISF QIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFM PILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS*" /label="steT CDS" gene complement(1189718..1191034) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /label="steT gene" downshifts complement(1189733) /Source="Nicolas_upshifts" /id="D700" /incds=0 /nref=3 /ntot=92 /MaxReadThrough="3.59461" /MaxDrop="3.97157" /score="23.3119204" /energy="-14.4" /TU="U1039" /idTUdmin="U1039" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1191081..1191100) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-10" upshifts complement(1191097) /Source="Nicolas_upshifts" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="upshifts" promotor_-35 complement(1191115..1191118) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-35" promotor_-35 1191317..1191324 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1191339..1191358 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1191351..1191422 /Source="Nicolas_S_feature" /locus_tag="new_1353008_1353079" /HighExp="Etha, dia15, Salt, Heat, dia5, Diami, H2O2, M9-stat, MG 25, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.964" /TUlongSig="NA" /TUlongPSig="NA" /label="S460" upshifts 1191351 /Source="Nicolas_upshifts" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="upshifts" CDS 1191423..1192373 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /EC_number="1.13.11.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17407181, 17725564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 17725564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroquinone-specific extradiol dioxygenase" /protein_id="NP_389170.1" /db_xref="EnsemblGenomes-Gn:BSU12870" /db_xref="EnsemblGenomes-Tr:CAB13144" /db_xref="GOA:O34689" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13228" /db_xref="UniProtKB/Swiss-Prot:O34689" /translation="MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMY HLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQV THSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVEL TVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRER QGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELS TDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ*" /label="mhqA CDS" gene 1191423..1192373 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /label="mhqA gene" downshifts 1192361 /Source="Nicolas_upshifts" /id="D701" /incds=0 /nref=95 /ntot=231 /MaxReadThrough="0.70251" /MaxDrop="5.11652" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1040" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 1192474..1192620 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513953.1" /translation="MLIGRNGLKPFANMGDWYGMASAKILSLFINSLFIFACYTISKL DKKE*" /label="hypothetical protein CDS" gene 1192474..1192620 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /label="gene" CDS 1192628..1194778 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane glycosyl transferase" /protein_id="NP_389171.2" /db_xref="EnsemblGenomes-Gn:BSU12880" /db_xref="EnsemblGenomes-Tr:CAB13145" /db_xref="GOA:O34575" /db_xref="SubtiList:BG13229" /db_xref="UniProtKB/Swiss-Prot:O34575" /translation="MEKKKRELDIVLLLILLASAFLNIYNIWKDDTVNPYYTAAVTSM MQSFHNFFYASFDAAGFITVDKPPVTYQIQTISALIFGMHGWSVILPQALAGVGSVLL MYLLIKPTFGKTAARIASFVMACTPIAVAVARTNNVDALLVFFLLLATWLLFKAIRKG KLIWLLAAFFVVGVGFNTKMLQAYMILPAFLLFYLIAANATIKKKIVSLVSALAVLAA VSLSWPLIVDNIPASKRPYIGSSQTNSVLELAFGYNGIQRLTGQNSGGGQGAPNKDAS KEMSSSDNTQAPPNQSSSNSSSSDGKSSNGNMAAPPSNGQMPSGGQGGPPSGGDGGQG GPGGDGGKGGTGTGSKMQSGSGMFGTGTPGPLRLFQQELSDQISWLLPFAIFGIAGLL IAGARERRRLSVEQKETVFWVAWLVPIAGFFSVAEFFHHYYLIMLAPPIAALVGAGWV ALVHLYRNQTGWKAWLLPGAIIATTGFELFILRNYNDQIGVGWSIGVGVIGVLSAIAL LLFKQRQKPFSYYVSLAALLALLVMPMYWASTPLLYGGNSSLPETGPQLASMSGKGMG MSDATVNEKLIKYLEENNSGAEYLFATTDSNTAAPYIIKTKKAVMAIGGYSGSDPAIT LTQFKKLVKEGKVKYFLASGMGRGGNNDIVEWVEKNGKEVASEKWQSSSDQKTENTDS ADTSSSKASGENGKMGGPGGMNQSATLYELHADE*" /label="ykcB CDS" gene 1192628..1194778 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /label="ykcB gene" promotor_no_box 1193517..1193617 /Source="Nicolas_upshift_promotors" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1193577 /Source="Nicolas_upshifts" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1193665 /Source="Nicolas_upshifts" /id="D702" /incds=1 /nref=4 /ntot=10 /MaxReadThrough="0.56615" /MaxDrop="4.44711" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1041" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1194790..1195761 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /EC_number="2.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389172.2" /db_xref="EnsemblGenomes-Gn:BSU12890" /db_xref="EnsemblGenomes-Tr:CAB13146" /db_xref="GOA:O34319" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13230" /db_xref="UniProtKB/Swiss-Prot:O34319" /translation="MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVN DGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDP PELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLS MDGITTFSHKPLKLASYAGILMSGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFS GIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQHMS*" /label="ykcC CDS" gene 1194790..1195761 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /label="ykcC gene" S_feature complement(1195118..1195759) /Source="Nicolas_S_feature" /locus_tag="new_1356775_1357416_c" /HighExp="T-0.40H, T0.0H, Salt, T0.30H, T-1.10H, C30, T-1.40H, S0, H2O2, T1.0H" /AntisenseName="ykcC" /AntisenseCor="9.6017422892053297E-4" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S461" downshifts complement(1195804) /Source="Nicolas_upshifts" /id="D703" /incds=0 /nref=9 /ntot=114 /MaxReadThrough="4.36795" /MaxDrop="4.15844" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=489 /isTUend="FALSE" /label="downshifts" S_feature complement(1195829..1196195) /Source="Nicolas_S_feature" /locus_tag="new_1357486_1357852_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T0.0H, T2.30H, T-0.40H, T3.0H, Salt, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99893799999999999" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S462" downshifts complement(1195872) /Source="Nicolas_upshifts" /id="D704" /incds=0 /nref=17 /ntot=157 /MaxReadThrough="6.61192" /MaxDrop="3.74411" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=421 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1196175..1196190) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1196195) /Source="Nicolas_upshifts" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1196202..1196211) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1196279..1197628) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /EC_number="3.4.21.107" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 11555295, 12823817, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 11555295, 12823817, 24362423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound serine protease Do, quality control protease and chaperone (heat-shock protein)" /protein_id="NP_389173.2" /db_xref="EnsemblGenomes-Gn:BSU12900" /db_xref="EnsemblGenomes-Tr:CAB13147" /db_xref="GOA:O34358" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG12608" /db_xref="UniProtKB/Swiss-Prot:O34358" /translation="MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRG FGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKK SSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDD HVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSI NVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELL SKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKA EDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS* " /label="htrA CDS" gene complement(1196279..1197628) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /label="htrA gene" downshifts complement(1196293) /Source="Nicolas_upshifts" /id="D705" /incds=0 /nref=198 /ntot=244 /MaxReadThrough="2.95586" /MaxDrop="5.35972" /score="30.7234179" /energy="-19.9" /TU="NA" /idTUdmin="U1044" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1197668..1197675 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-35" promotor_-10 complement(1197680..1197699) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1197688 /Source="Nicolas_upshifts" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="upshifts" promotor_-10 1197690..1197709 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-10" upshifts complement(1197698) /Source="Nicolas_upshifts" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1197700..1197782) /Source="Nicolas_S_feature" /locus_tag="new_1359357_1359439_c" /HighExp="Etha, dia5, S8, S6, T2.0H, T3.30H, dia15, T5.0H, BC, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.682" /TUlongSig="NA" /TUlongPSig="NA" /label="S463" promotor_-35 complement(1197710..1197717) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1197739..1197745 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1197760..1197779 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1197763 /Source="Nicolas_upshifts" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1197765..1197784) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1197782) /Source="Nicolas_upshifts" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1197797..1198615 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /EC_number="1.5.1.2" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redundant pyrroline-5-carboxylate reductase" /protein_id="NP_389174.1" /db_xref="EnsemblGenomes-Gn:BSU12910" /db_xref="EnsemblGenomes-Tr:CAB13148" /db_xref="GOA:Q00777" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10841" /db_xref="UniProtKB/Swiss-Prot:Q00777" /translation="MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRA LMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPL RLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKE SNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKN MSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT*" /label="proCC CDS" gene 1197797..1198615 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /label="proCC gene" promotor_-35 complement(1197800..1197803) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1198593 /Source="Nicolas_upshifts" /id="D706" /incds=0 /nref=90 /ntot=220 /MaxReadThrough="1.3818" /MaxDrop="4.43155" /score="-5.08770006" /energy="-5.3" /TU="NA" /idTUdmin="U1045" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1198672..1198679 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1198694..1198713 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1198698 /Source="Nicolas_upshifts" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1198744..1199568 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11069674, 11473256, 19340926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069674, 11473256, 19340926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-aminopeptidase" /protein_id="NP_389175.2" /db_xref="EnsemblGenomes-Gn:BSU12920" /db_xref="EnsemblGenomes-Tr:CAB13149" /db_xref="GOA:P26902" /db_xref="InterPro:IPR007035" /db_xref="InterPro:IPR027476" /db_xref="InterPro:IPR033824" /db_xref="InterPro:IPR036177" /db_xref="PDB:1HI9" /db_xref="SubtiList:BG10842" /db_xref="UniProtKB/Swiss-Prot:P26902" /translation="MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIA EAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLG YHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKE AEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPV LSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC*" /label="dppA CDS" gene 1198744..1199568 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /label="dppA gene" CDS 1199585..1200511 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389176.1" /db_xref="EnsemblGenomes-Gn:BSU12930" /db_xref="EnsemblGenomes-Tr:CAB13150" /db_xref="GOA:P26903" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10843" /db_xref="UniProtKB/Swiss-Prot:P26903" /translation="MARYMIKRFWAMAATILVITTLTFVLMKVIPGSPFNEERGTNEA VQKNLEAYYHLDDPLIFQYIFYLKSIITFDFGPSIKKPSDSVNDMLERGFPVSFELGM TAIVIAVISGLVLGVIAALRRNGFLDYAAMSLAVLGISIPNFILATLLIQQFAVNLKL FPAATWTSPIHMVLPTAALAVGPMAIIARLTRSSMVEVLTQDYIRTAKAKGLSPFKII VKHALRNALMPVITVLGTLVASILTGSFVIEKIFAIPGMGKYFVESINQRDYPVIMGT TVFYSVILIIMLFLVDLAYGLLDPRIKLHKKG*" /label="dppB CDS" gene 1199585..1200511 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /label="dppB gene" CDS 1200517..1201479 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389177.1" /db_xref="EnsemblGenomes-Gn:BSU12940" /db_xref="EnsemblGenomes-Tr:CAB13151" /db_xref="GOA:P26904" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10844" /db_xref="UniProtKB/Swiss-Prot:P26904" /translation="MNLPVQTDERQPEQHNQVPDEWFVLNQEKNREADSVKRPSLSYT QDAWRRLKKNKLAMAGLFILLFLFVMAVIGPFLSPHSVVRQSLTEQNLPPSADHWFGT DELGRDVFTRTWYGARISLFVGVMAALIDFLIGVIYGGVAGYKGGRIDSIMMRIIEVL YGLPYLLVVILLMVLMGPGLGTIIVALTVTGWVGMARIVRGQVLQIKNYEYVLASKTF GAKTFRIIRKNLLPNTMGAIIVQMTLTVPAAIFAESFLSFLGLGIQAPFASWGVMAND GLPTILSGHWWRLFFPAFFISLTMYAFNVLGDGLQDALDPKLRR*" /label="dppC CDS" gene 1200517..1201479 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /label="dppC gene" promotor_-35 1201211..1201216 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1201232..1201250 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1201233 /Source="Nicolas_upshifts" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1201484..1202491 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7536291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7536291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (ATP-binding subunit)" /protein_id="NP_389178.1" /db_xref="EnsemblGenomes-Gn:BSU12950" /db_xref="EnsemblGenomes-Tr:CAB13152" /db_xref="GOA:P26905" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10845" /db_xref="UniProtKB/Swiss-Prot:P26905" /translation="MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESG CGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMT ALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGM RQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGV VAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTP PDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAK D*" /label="dppD CDS" gene 1201484..1202491 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /label="dppD gene" CDS 1202494..1204143 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7783641, 8793880, 11390694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783641, 8793880, 11390694; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (dipeptide-binding lipoprotein)" /protein_id="NP_389179.2" /db_xref="EnsemblGenomes-Gn:BSU12960" /db_xref="EnsemblGenomes-Tr:CAB13153" /db_xref="GOA:P26906" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10846" /db_xref="UniProtKB/Swiss-Prot:P26906" /translation="MKRGKRMKRVKKLWGMGLALGLSFALMGCTANEQAGKEGSHDKA KTSGEKVLYVNNENEPTSFDPPIGFNNVSWQPLNNIMEGLTRLGKDHEPEPAMAEKWS VSKDNKTYTFTIRENAKWTNGDPVTAGDFEYAWKRMLDPKKGASSAFLGYFIEGGEAY NSGKGKKDDVKVTAKDDRTLEVTLEAPQKYFLSVVSNPAYFPVNEKVDKDNPKWFAES DTFVGNGPFKLTEWKHDDSITMEKSDTYWDKDTVKLDKVKWAMVSDRNTDYQMFQSGE LDTAYVPAELSDQLLDQDNVNIVDQAGLYFYRFNVNMEPFQNENIRKAFAMAVDQEEI VKYVTKNNEKPAHAFVSPGFTQPDGKDFREAGGDLIKPNESKAKQLLEKGMKEENYNK LPAITLTYSTKPEHKKIAEAIQQKLKNSLGVDVKLANMEWNVFLEDQKALKFQFSQSS FLPDYADPISFLEAFQTGNSMNRTGWANKEYDQLIKQAKNEADEKTRFSLMHQAEELL INEAPIIPVYFYNQVHLQNEQVKGIVRHPVGYIDLKWADKN*" /label="dppE CDS" gene 1202494..1204143 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /label="dppE gene" downshifts 1204137 /Source="Nicolas_upshifts" /id="D707" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="6.73127" /MaxDrop="3.5888" /score="22.838155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-4469" /isTUend="FALSE" /label="downshifts" CDS 1204231..1205190 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /EC_number="3.4.17.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10428950, 15101989, 18535144, 20944232, 24123814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="muropeptide L,D-carboxypeptidase" /protein_id="NP_389180.2" /db_xref="EnsemblGenomes-Gn:BSU12970" /db_xref="EnsemblGenomes-Tr:CAB13154" /db_xref="GOA:O34851" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13231" /db_xref="UniProtKB/Swiss-Prot:O34851" /translation="MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEEL GLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDF SLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLF QETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDE EPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPA LRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT*" /label="ldcA CDS" gene 1204231..1205190 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /label="ldcA gene" CDS 1205187..1206287 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /EC_number="5.1.1.20" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11747447, 11747448, 15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11747447, 11747448, 15101989; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-Ala-D/L-Glu epimerase" /protein_id="NP_389181.1" /db_xref="EnsemblGenomes-Gn:BSU12980" /db_xref="EnsemblGenomes-Tr:CAB13155" /db_xref="GOA:O34508" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:1JPM" /db_xref="PDB:1TKK" /db_xref="SubtiList:BG13232" /db_xref="UniProtKB/Swiss-Prot:O34508" /translation="MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVG WGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAA VEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLK IKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELV EQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGIS GAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFN GGITYSGSTISMPGKPGLGIIGAALLKGEKEQ*" /label="aeeB CDS" gene 1205187..1206287 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /label="aeeB gene" CDS 1206284..1207174 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989, 20944232" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 20944232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamyl-L-diaminoacid endopeptidase" /protein_id="NP_389182.2" /db_xref="EnsemblGenomes-Gn:BSU12990" /db_xref="EnsemblGenomes-Tr:CAB13156" /db_xref="GOA:O35010" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG13233" /db_xref="UniProtKB/Swiss-Prot:O35010" /translation="MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDE RLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKT KPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQ SDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRD AGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEIL TLTETIYEKELCAVRRCFSE*" /label="eepC CDS" gene 1206284..1207174 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /label="eepC gene" CDS 1207187..1208176 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cell wall oligopeptide ABC transporter (ATP binding protein)" /protein_id="NP_389183.2" /db_xref="EnsemblGenomes-Gn:BSU13000" /db_xref="EnsemblGenomes-Tr:CAB13157" /db_xref="GOA:C0SP98" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13234" /db_xref="UniProtKB/Swiss-Prot:C0SP98" /translation="MRRLPLLEVSQLKMHFDAGKKRTVKAVDGVTFQIREGETFGLVG ESGCGKSTLGRVLMRLYQPTEGSVTYRGTNLHALSEKEQFAFNRKLQMIFQDPYASLN PRMTVREIILEPMEIHNLYNTHKARLLVVDELLEAVGLHPDFGSRYPHEFSGGQRQRI GIARALSLNPEFIVADEPISALDVSVQAQVVNLLKRLQKEKGLTFLFIAHDLSMVKHI SDRIGVMYLGHMMEITESGTLYREPLHPYTKALLSSIPIPDPELEDKRERILLKGELP SPVNPPSGCVFRTRCPEAMPECGESRPQLQEIEPGRFVACHLYRNAETKEKVR*" /label="ykfD CDS" gene 1207187..1208176 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /label="ykfD gene" S_feature complement(1207470..1208197) /Source="Nicolas_S_feature" /locus_tag="new_1369127_1369854_c" /HighExp="Etha, S7, Gly, M40t90, C30, H2O2, M0t90, dia15, T1.0H, S8" /AntisenseName="ykfD" /AntisenseCor="-6.3474114158352593E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S464" downshifts 1208166 /Source="Nicolas_upshifts" /id="D708" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="5.08319" /MaxDrop="3.1399" /score="-3.10371155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" S_feature 1208211..1209379 /Source="Nicolas_S_feature" /locus_tag="new_1369868_1371036" /HighExp="T3.30H, T4.0H, T3.0H, T5.0H, T2.30H, T2.0H, S1, M9-stat, T1.30H, HiOs" /AntisenseName="ykgB" /AntisenseCor="-0.33524952291190102" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S465" CDS complement(1208219..1209268) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /EC_number="3.1.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22960854, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconolactonase" /protein_id="NP_389184.1" /db_xref="EnsemblGenomes-Gn:BSU13010" /db_xref="EnsemblGenomes-Tr:CAB13158" /db_xref="GOA:O34499" /db_xref="InterPro:IPR011048" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019405" /db_xref="SubtiList:BG13236" /db_xref="UniProtKB/Swiss-Prot:O34499" /translation="MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPT YVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQ FVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYV VAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIA LEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQ YSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPST VSVPYPVCVKFLHQV*" /label="pgl CDS" gene complement(1208219..1209268) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /label="pgl gene" downshifts complement(1208242) /Source="Nicolas_upshifts" /id="D709" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="5.12776" /MaxDrop="6.0668" /score="24.6986564" /energy="-15.6" /TU="U1050" /idTUdmin="U1049" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1209295..1209314) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1209306) /Source="Nicolas_upshifts" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1209329..1209336) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1209358..1210218) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /EC_number="3.5.3.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27258038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N(G),N(G)-dimethylarginine dimethylaminohydrolase" /protein_id="NP_389185.2" /db_xref="EnsemblGenomes-Gn:BSU13020" /db_xref="EnsemblGenomes-Tr:CAB13159" /db_xref="GOA:O34497" /db_xref="InterPro:IPR033199" /db_xref="SubtiList:BG13235" /db_xref="UniProtKB/Swiss-Prot:O34497" /translation="MDVSIPKSQHKTVCRTEYGTLQKVILCKPEHMTIKDVINETQKH FEDDNIHVKTANDQHSRLVEALRSHNVEVVLLPVRDGLPEQVFTRDIGFVIGEKAFLS SMTEPIRQGEEAVIKDFFHSQGISYTRMLDTSIEGGDVIIDDDIVYVGISQRTDISAI GQLEEALPEYTIVPVKLHEKFLHLDCVFNIISESEALIYSQAIEPDAADMLAKRYDLI EVPEDEQFTLGTNVLSIGKKTIISLPGNRHVNQQLSKRGYHIIEIDLSEIIKSGGSFR CCTMPLIRGE*" /label="ddaH CDS" gene complement(1209358..1210218) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /label="ddaH gene" promotor_-10 complement(1210243..1210261) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1210260) /Source="Nicolas_upshifts" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1210277..1210283) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1210292..1210299 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1210313..1210332 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1210320 /Source="Nicolas_upshifts" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="upshifts" CDS 1210378..1210896 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /EC_number="3.1.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12426338, 18247525, 24623648, 24722906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acyl-CoA thioesterase" /protein_id="NP_389186.2" /db_xref="EnsemblGenomes-Gn:BSU13030" /db_xref="EnsemblGenomes-Tr:CAB13160" /db_xref="GOA:P49851" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR033120" /db_xref="SubtiList:BG11417" /db_xref="UniProtKB/Swiss-Prot:P49851" /translation="METPETRFCKESKVVKTSRVFPLDTNNHNTLFGGKLMSYIDDIA SISAARHCRRETVTASMDSVDFLKPIGQKDSVCLESYVTWVGTSSMEVFVKVIKEHLM TGERELAATSFLTFVALDSNGKPVPVPRVVPETEEEIMLHNTAVQRANERKNRKRHSQ ALANALGTDKPW*" /label="ykhA CDS" gene 1210378..1210896 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /label="ykhA gene" downshifts 1210887 /Source="Nicolas_upshifts" /id="D710" /incds=0 /nref=34 /ntot=265 /MaxReadThrough="4.66856" /MaxDrop="4.77681" /score="24.0889455" /energy="-10.9" /TU="U1051" /idTUdmin="U1051" /TUdmin="-1436" /isTUend="FALSE" /label="downshifts" promotor_-35 1210961..1210967 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-35" S_feature 1210979..1211085 /Source="Nicolas_S_feature" /locus_tag="new_1372636_1372742" /HighExp="Etha, S5, S6, S8, nit, S7, ferm, S4, dia15, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S466" upshifts 1210979 /Source="Nicolas_upshifts" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="upshifts" promotor_-10 1210981..1210992 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-10" promotor_-35 1211060..1211063 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1211079..1211098 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1211087 /Source="Nicolas_upshifts" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1211135..1212334 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044; Product type c: carrier" /codon_start=1 /transl_table=11 /product="flavohemoglobin" /protein_id="NP_389187.1" /db_xref="EnsemblGenomes-Gn:BSU13040" /db_xref="EnsemblGenomes-Tr:CAB13161" /db_xref="GOA:P49852" /db_xref="InterPro:IPR000971" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023950" /db_xref="SubtiList:BG11418" /db_xref="UniProtKB/Swiss-Prot:P49852" /translation="MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFN QTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYL LIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIA KKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDY YRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMIS MLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGD LHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQ LSLAQSV*" /label="hmpA CDS" gene 1211135..1212334 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /label="hmpA gene" downshifts 1212323 /Source="Nicolas_upshifts" /id="D711" /incds=0 /nref=10 /ntot=59 /MaxReadThrough="6.06442" /MaxDrop="4.19301" /score="11.2868967" /energy="-9.3" /TU="U1053" /idTUdmin="U1051" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1212368..1212739 /Source="Nicolas_S_feature" /locus_tag="new_1374025_1374396" /HighExp="nit, B36, B60, Etha, BI, M40t90, LBGtran, M0t90, BT, S6" /AntisenseName="ykzH" /AntisenseCor="7.6554747052539299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigGF" /TUlongPSig="0.998" /label="S467" CDS complement(1212411..1212635) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389188.1" /db_xref="EnsemblGenomes-Gn:BSU13050" /db_xref="EnsemblGenomes-Tr:CAB13162" /db_xref="SubtiList:BG13336" /db_xref="UniProtKB/Swiss-Prot:O31653" /translation="MKNQKSNTLWPFDLPLAPQPEGYQQQTIDRLAGLELRMKQLIRA IEVNNELLRTMQEQQNRVCTNGSGSVIVRM*" /label="ykzH CDS" gene complement(1212411..1212635) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /label="ykzH gene" promotor_-35 1212715..1212721 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1212735..1212746 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1212741 /Source="Nicolas_upshifts" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1212780..1213511 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389189.1" /db_xref="EnsemblGenomes-Gn:BSU13060" /db_xref="EnsemblGenomes-Tr:CAB13163" /db_xref="GOA:P49853" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG11419" /db_xref="UniProtKB/Swiss-Prot:P49853" /translation="MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFA IGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDID ERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNM EAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARG DISLDLNTANEPQHDPYLYKPGNNN*" /label="ykjA CDS" gene 1212780..1213511 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /label="ykjA gene" downshifts 1213489 /Source="Nicolas_upshifts" /id="D712" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="2.84532" /MaxDrop="4.44655" /score="17.2468985" /energy="-7.2" /TU="U1053" /idTUdmin="U1054" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1213550..1213558 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1213569..1213587 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1213577 /Source="Nicolas_upshifts" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1213603..1214130 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389190.1" /db_xref="EnsemblGenomes-Gn:BSU13070" /db_xref="EnsemblGenomes-Tr:CAB13164" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG11420" /db_xref="UniProtKB/Swiss-Prot:P49854" /translation="MKDLSIRNDMAPTVSLLYSAVEENSLRLASIVSHMTHSELYYKG RCQTKNSTAQLLHHITNVDIRWVWRIKENRIPDHIEQAYGPMTDESGRLPEPVNQPDL DELLKRHQHVVEKLKSVCFTLTENALNQPLSFEGDTATIRWGIWHMADHNRYHQAHIE ALKKEWKQDVAKYER*" /label="ykkA CDS" gene 1213603..1214130 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /label="ykkA gene" CDS 1214120..1214638 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389191.1" /db_xref="EnsemblGenomes-Gn:BSU13080" /db_xref="EnsemblGenomes-Tr:CAB13165" /db_xref="GOA:P49855" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11421" /db_xref="UniProtKB/Swiss-Prot:P49855" /translation="MNAKTKLVTDRIRLRCMEDRDQATLFGLLFNDPDVMTYYSGLKD KRQTREWVNWNQRNEKGYGVSLWIAEDKRTGEFLGQCGIVPQQIENQTVMEIGYMFAR RHWGNGYAQEAARACLDYGFNERQFGKMAALIDPGNKASIRVAEKIGMHYSKTIRKWN KPIAVYERKSYN*" /label="ykkB CDS" gene 1214120..1214638 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /label="ykkB gene" promotor_-35 1214632..1214639 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-35" promotor_-10 1214653..1214672 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-10" upshifts 1214656 /Source="Nicolas_upshifts" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="upshifts" misc_RNA 1214671..1214782 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /product="guanidine-sensing riboswitch (binds free guanidinium)" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17908319, 21317561, 27989440, 28001368, 28017522, 28107646, 28212758; Product type n: RNA" /label="gdwA RNA" gene 1214671..1214782 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /label="gdwA gene" downshifts 1214745 /Source="Nicolas_upshifts" /id="D713" /incds=0 /nref=205 /ntot=246 /MaxReadThrough="3.70824" /MaxDrop="6.58389" /score="30.3456563" /energy="-18.5" /TU="U1056" /idTUdmin="U1056" /TUdmin="-789" /isTUend="FALSE" /label="downshifts" CDS 1214860..1215198 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389192.1" /db_xref="EnsemblGenomes-Gn:BSU13090" /db_xref="EnsemblGenomes-Tr:CAB13166" /db_xref="GOA:P49856" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11422" /db_xref="UniProtKB/Swiss-Prot:P49856" /translation="MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLM KATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQ DETEEKGGEA*" /label="gdnC CDS" gene 1214860..1215198 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /label="gdnC gene" CDS 1215198..1215515 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389193.1" /db_xref="EnsemblGenomes-Gn:BSU13100" /db_xref="EnsemblGenomes-Tr:CAB13167" /db_xref="GOA:P49857" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11423" /db_xref="UniProtKB/Swiss-Prot:P49857" /translation="MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASF SLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLK ILS*" /label="gdnD CDS" gene 1215198..1215515 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /label="gdnD gene" promotor_-35 1215515..1215518 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1215534..1215553 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1215546 /Source="Nicolas_upshifts" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1215586..1216488 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /EC_number="3.5.1.10" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8226647, 24108189; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formyltetrahydrofolate hydrolase" /protein_id="NP_389194.2" /db_xref="EnsemblGenomes-Gn:BSU13110" /db_xref="EnsemblGenomes-Tr:CAB13168" /db_xref="GOA:O34990" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004810" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG13237" /db_xref="UniProtKB/Swiss-Prot:O34990" /translation="MKSYMTQRLDEYRDGNEDKGRLLVSCPDQPGIVSAVSAFLFEHG ANIIESNQYTTDPEGGRFFLRIEFDCAGIREKKSSLQAAFASVAEKFDMTWSLTLASE LKRVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHEEARELVERLNIPFHYMKAN KDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDFVSAHPNRIINIHHSFLPAFIGA NPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERVDHRDNAEALKNIGRTIERSV LARAVKWHLEDRVIVHENKTIVFN*" /label="purU CDS" gene 1215586..1216488 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /label="purU gene" downshifts 1216479 /Source="Nicolas_upshifts" /id="D714" /incds=0 /nref=91 /ntot=226 /MaxReadThrough="3.55628" /MaxDrop="5.02155" /score="16.8011006" /energy="-13.1" /TU="U1057" /idTUdmin="U1056" /TUdmin=945 /isTUend="FALSE" /label="downshifts" promotor_-35 1216535..1216541 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1216547 /Source="Nicolas_upshifts" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1216555..1216574 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1216576..1216786 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /product="T-box riboswitch specific of proline tRNA" /experiment="publication(s) with functional evidences, PMID:11917026, 12749771, 19932103, 21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11917026, 12749771, 19932103, 21233158; Product type n: RNA" /function="16.3: Control" /label="pswB RNA" gene 1216576..1216786 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /label="pswB gene" downshifts 1216744 /Source="Nicolas_upshifts" /id="D715" /incds=0 /nref=4 /ntot=52 /MaxReadThrough="6.91996" /MaxDrop="3.8361" /score="29.5878921" /energy="-17.6" /TU="U1057,U1058" /idTUdmin="U1056" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1216839..1217936 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /EC_number="2.7.2.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21233158, 21784929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21233158, 21784929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389195.2" /db_xref="EnsemblGenomes-Gn:BSU13120" /db_xref="EnsemblGenomes-Tr:CAB13169" /db_xref="GOA:P39820" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10963" /db_xref="UniProtKB/Swiss-Prot:P39820" /translation="MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEM ILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILL TRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIH ADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLL ATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPIS GEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEE IMEAKGKRSDELDFEKTFEVIHRNDWVNVKD*" /label="proB CDS" gene 1216839..1217936 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /label="proB gene" promotor_-35 1217026..1217028 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1217030..1217034 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1217030 /Source="Nicolas_upshifts" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1217948..1219195 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /EC_number="1.2.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21784929, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21784929, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="NP_389196.2" /db_xref="EnsemblGenomes-Gn:BSU13130" /db_xref="EnsemblGenomes-Tr:CAB13170" /db_xref="GOA:P39821" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR012134" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR020593" /db_xref="SubtiList:BG10964" /db_xref="UniProtKB/Swiss-Prot:P39821" /translation="MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFL LAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKE NGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSV IYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVP VLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELL DQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQY GTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHAR GPMGLPALTSTKYIIKGTGQIRE*" /label="proA CDS" gene 1217948..1219195 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /label="proA gene" downshifts 1219186 /Source="Nicolas_upshifts" /id="D716" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="4.1607" /MaxDrop="6.017" /score="11.118012" /energy="-11" /TU="U1058" /idTUdmin="U1059" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1219257..1219264 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1219279..1219298 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1219288 /Source="Nicolas_upshifts" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1219321..1219746 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11418552, 17502599, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418552, 17502599, 21749987, 24184231; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin" /protein_id="NP_389197.1" /db_xref="EnsemblGenomes-Gn:BSU13140" /db_xref="EnsemblGenomes-Tr:CAB13171" /db_xref="GOA:O34762" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13238" /db_xref="UniProtKB/Swiss-Prot:O34762" /translation="MSQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEK ATNPEQLFAAGYAACFDSALQLVARTERVKVETEVTANVSLLKDEADQGYKLGVTLQV KGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE*" /label="ohrA CDS" gene 1219321..1219746 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /label="ohrA gene" downshifts 1219735 /Source="Nicolas_upshifts" /id="D717" /incds=0 /nref=57 /ntot=174 /MaxReadThrough="0.0429100000000009" /MaxDrop="3.90314" /score="30.9245751" /energy="-16.6" /TU="NA" /idTUdmin="U1060" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1219777..1220220) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11983871, 17502599, 18363800, 20094649, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11983871, 17502599, 18363800, 20094649, 21749987, 24184231; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator sensing organic peroxides" /protein_id="NP_389198.1" /db_xref="EnsemblGenomes-Gn:BSU13150" /db_xref="EnsemblGenomes-Tr:CAB13172" /db_xref="GOA:O34777" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1Z91" /db_xref="PDB:1Z9C" /db_xref="SubtiList:BG13239" /db_xref="UniProtKB/Swiss-Prot:O34777" /translation="MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYL ALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTE DGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN*" /label="ohrR CDS" gene complement(1219777..1220220) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /label="ohrR gene" downshifts complement(1219811) /Source="Nicolas_upshifts" /id="D718" /incds=0 /nref=105 /ntot=232 /MaxReadThrough="-0.17111" /MaxDrop="4.73026" /score="34.7008532" /energy="-16.6" /TU="NA" /idTUdmin="U1061" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1220247..1220266) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1220253) /Source="Nicolas_upshifts" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1220281..1220284) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1220302..1220308 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1220322..1220340 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1220328 /Source="Nicolas_upshifts" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="upshifts" CDS 1220363..1220773 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9696771, 11418552, 18084074" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696771, 11418552, 18084074; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="organic hydroperoxide resistance reductase B" /protein_id="NP_389199.1" /db_xref="EnsemblGenomes-Gn:BSU13160" /db_xref="EnsemblGenomes-Tr:CAB13173" /db_xref="GOA:P80242" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="PDB:2BJO" /db_xref="SubtiList:BG19021" /db_xref="UniProtKB/Swiss-Prot:P80242" /translation="MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNP EQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKD LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK*" /label="ohrB CDS" gene 1220363..1220773 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /label="ohrB gene" downshifts 1220751 /Source="Nicolas_upshifts" /id="D719" /incds=0 /nref=7 /ntot=145 /MaxReadThrough="8.17185" /MaxDrop="4.0663" /score="17.6512157" /energy="-12.1" /TU="U1062" /idTUdmin="U1062" /TUdmin="-855" /isTUend="FALSE" /label="downshifts" CDS 1220800..1220970 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097717.1" /db_xref="EnsemblGenomes-Gn:BSU13169" /db_xref="EnsemblGenomes-Tr:CAX52607" /db_xref="UniProtKB/Swiss-Prot:C0H400" /translation="MFFGVGHAGRAQIYDKTSEKRLKHAFKPKVTDEAGGWHGVCRAE LRVYAVLYLHRA*" /label="ykzN CDS" gene 1220800..1220970 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /label="ykzN gene" S_feature 1220971..1221648 /Source="Nicolas_S_feature" /locus_tag="new_1382628_1383305" /HighExp="Etha, Salt, M9-stat, Sw, B60, LPhT, B36, Heat, Gly, BC" /AntisenseName="guaD" /AntisenseCor="-5.7732597431508298E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S468" CDS complement(1221020..1221490) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /EC_number="3.5.4.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11101664, 15180998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101664, 15180998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanine deaminase" /protein_id="NP_389200.1" /db_xref="EnsemblGenomes-Gn:BSU13170" /db_xref="EnsemblGenomes-Tr:CAB13174" /db_xref="GOA:O34598" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1TIY" /db_xref="PDB:1WKQ" /db_xref="SubtiList:BG13240" /db_xref="UniProtKB/Swiss-Prot:O34598" /translation="MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNV TTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAA EHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY*" /label="guaN CDS" gene complement(1221020..1221490) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /label="guaN gene" downshifts complement(1221044) /Source="Nicolas_upshifts" /id="D720" /incds=0 /nref=25 /ntot=112 /MaxReadThrough="0.698199999999999" /MaxDrop="4.30578" /score="-6.41557266" /energy="-13.5" /TU="NA" /idTUdmin="U1063" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1221512..1221531) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1221528) /Source="Nicolas_upshifts" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1221530..1221637) /Source="Nicolas_S_feature" /locus_tag="new_1383187_1383294_c" /HighExp="BMM, MG 10, MG 15, MG 5, MG t5, GM 25, B36, Gly, B60, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.044, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S469" promotor_-35 complement(1221547..1221550) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1221606 /Source="Nicolas_upshifts" /id="D721" /incds=0 /nref=9 /ntot=34 /MaxReadThrough="0.95942" /MaxDrop="5.95076" /score="15.2916843" /energy="-11.5" /TU="NA" /idTUdmin="U1062" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1221663..1223951) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /EC_number="2.1.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cobalamin-independent methionine synthase" /protein_id="NP_389201.2" /db_xref="EnsemblGenomes-Gn:BSU13180" /db_xref="EnsemblGenomes-Tr:CAB13175" /db_xref="GOA:P80877" /db_xref="InterPro:IPR002629" /db_xref="InterPro:IPR006276" /db_xref="InterPro:IPR013215" /db_xref="SubtiList:BG12616" /db_xref="UniProtKB/Swiss-Prot:P80877" /translation="MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDEL FLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGI KDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGP YTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRG AKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTH GFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKH PDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGA NSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQK WRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFT KYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWS FPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTW AAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLK NHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEET VAALKNMVEAAKQARAQQTQLV*" /label="metE CDS" gene complement(1221663..1223951) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /label="metE gene" downshifts complement(1221682) /Source="Nicolas_upshifts" /id="D722" /incds=0 /nref=212 /ntot=239 /MaxReadThrough="5.25958" /MaxDrop="7.50935" /score="29.3354648" /energy="-11.5" /TU="U1064,U1065" /idTUdmin="U1063" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature complement(1223952..1224014) /Source="Nicolas_S_feature" /locus_tag="new_1385609_1385671_c" /HighExp="MG 15, MG 5, MG t5, BMM, T-1.40H, MG 25, MG 10, GM 25, Mal, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.044, 1, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S470" promotor_no_box complement(1223974..1224074) /Source="Nicolas_upshift_promotors" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1224014) /Source="Nicolas_upshifts" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1224079..1224234) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762, 22543867" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762, 22543867; Product type n : RNA" /function="16.3: Control" /label="mswB RNA" gene complement(1224079..1224234) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /label="mswB gene" downshifts complement(1224080) /Source="Nicolas_upshifts" /id="D723" /incds=0 /nref=55 /ntot=106 /MaxReadThrough="8.12248" /MaxDrop="6.4813" /score="24.0596293" /energy="-16.2" /TU="U1065,U1066" /idTUdmin="U1066" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1224267..1224286) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1224279) /Source="Nicolas_upshifts" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1224281..1224366) /Source="Nicolas_S_feature" /locus_tag="new_1385938_1386023_c" /HighExp="BT, BC, B36, M9-stat, T5.0H, S3, S6, T4.0H, S5, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S471" promotor_-35 complement(1224302..1224309) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1224367..1225326) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3087947, 14680823, 23569278" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3087947, 14680823, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="intracellular serine protease" /protein_id="NP_389202.1" /db_xref="EnsemblGenomes-Gn:BSU13190" /db_xref="EnsemblGenomes-Tr:CAB13176" /db_xref="GOA:P11018" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG10674" /db_xref="UniProtKB/Swiss-Prot:P11018" /translation="MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNI KVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNG GIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELK EAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNAN KEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEV FAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL*" /label="ispA CDS" gene complement(1224367..1225326) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /label="ispA gene" S_feature complement(1225327..1225378) /Source="Nicolas_S_feature" /locus_tag="new_1386984_1387035_c" /HighExp="BT, B36, BC, T5.0H, M9-stat, T0.30H, T3.30H, T3.0H, T4.0H, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S472" promotor_-10 complement(1225371..1225390) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1225383) /Source="Nicolas_upshifts" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1225404..1225410) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1225495..1225498 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1225511 /Source="Nicolas_upshifts" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1225514..1225533 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1225549..1226382 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_389203.1" /db_xref="EnsemblGenomes-Gn:BSU13200" /db_xref="EnsemblGenomes-Tr:CAB13177" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12609" /db_xref="UniProtKB/Swiss-Prot:O34860" /translation="MKLNEKLYAFFSEHVEQMAEEWIETMEESDPNSLYALHNATVTE ELKEQDREFYRHLNYMYVLPEKQFLEEFQEWVIELTNDQKHLDTPVQYVIREFMRNRR LYTKYFEKFAEENESAFEPGEKQKWADLIVKVFDFTIYTFVDHAEMNAKQQLNAQREM ILELSSPVITLSKSTALLPLVGDIDTERAKFILENTLQACAKRRVEHLLIDLSGVVVV DTMVAHQIFKLIEALNLIGVRSTLSGIRPEIAQTAVQLGIDFSNITIKTNLAQALNYH Q*" /label="rsbRB CDS" gene 1225549..1226382 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /label="rsbRB gene" downshifts 1226358 /Source="Nicolas_upshifts" /id="D724" /incds=0 /nref=219 /ntot=254 /MaxReadThrough="3.01586" /MaxDrop="6.07238" /score="22.2655638" /energy="-12.1" /TU="NA" /idTUdmin="U1067" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1226413..1227177) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, transmembrane T component" /protein_id="NP_389204.1" /db_xref="EnsemblGenomes-Gn:BSU13210" /db_xref="EnsemblGenomes-Tr:CAB13178" /db_xref="GOA:O34572" /db_xref="InterPro:IPR003339" /db_xref="SubtiList:BG13248" /db_xref="UniProtKB/Swiss-Prot:O34572" /translation="MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGV LLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSV GISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDE VQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRN RTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS*" /label="thiX CDS" gene complement(1226413..1227177) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /label="thiX gene" downshifts complement(1226434) /Source="Nicolas_upshifts" /id="D725" /incds=0 /nref=143 /ntot=164 /MaxReadThrough="0.824010000000001" /MaxDrop="6.67697" /score="34.7739353" /energy="-12.1" /TU="NA" /idTUdmin="U1069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1227152..1228795) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine ABC transporter (ATP-binding subunit)" /protein_id="NP_389205.2" /db_xref="EnsemblGenomes-Gn:BSU13220" /db_xref="EnsemblGenomes-Tr:CAB13179" /db_xref="GOA:O34362" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13249" /db_xref="UniProtKB/Swiss-Prot:O34362" /translation="MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPS GCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQF CMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALA CILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIER TIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKE PIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKS TLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLF GQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEP TFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPA QLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH*" /label="thiW CDS" gene complement(1227152..1228795) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /label="thiW gene" CDS complement(1228782..1229381) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 27447050, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 27447050, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, permease component" /protein_id="NP_389206.2" /db_xref="EnsemblGenomes-Gn:BSU13230" /db_xref="EnsemblGenomes-Tr:CAB13180" /db_xref="GOA:O34738" /db_xref="InterPro:IPR017195" /db_xref="PDB:5EDL" /db_xref="SubtiList:BG13250" /db_xref="UniProtKB/Swiss-Prot:O34738" /translation="MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEP IYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAV FLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLA GLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL*" /label="thiV CDS" gene complement(1228782..1229381) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /label="thiV gene" CDS complement(1229383..1229985) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15451668, 16291685, 16356850, 20471400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15451668, 16291685, 16356850, 20471400; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiamine-binding protein (oxidation stress protein)" /protein_id="NP_389207.1" /db_xref="EnsemblGenomes-Gn:BSU13240" /db_xref="EnsemblGenomes-Tr:CAB13181" /db_xref="GOA:O34911" /db_xref="InterPro:IPR011522" /db_xref="InterPro:IPR015835" /db_xref="InterPro:IPR029756" /db_xref="PDB:1S7H" /db_xref="PDB:1S99" /db_xref="PDB:1SBR" /db_xref="SubtiList:BG13251" /db_xref="UniProtKB/Swiss-Prot:O34911" /translation="MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKT DHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKR VNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDA HDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG*" /label="thiU CDS" gene complement(1229383..1229985) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /label="thiU gene" downshifts complement(1230063) /Source="Nicolas_upshifts" /id="D726" /incds=0 /nref=28 /ntot=88 /MaxReadThrough="7.47395" /MaxDrop="5.73297" /score="19.7469386" /energy="-10.9" /TU="U1069" /idTUdmin="U1069" /TUdmin="-3629" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1230082..1230194) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /product="thiamine pyrophosphate riboswitch" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswB RNA" gene complement(1230082..1230194) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /label="tswB gene" promotor_-35 1230195..1230198 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1230209..1230228) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1230214..1230233 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1230225 /Source="Nicolas_upshifts" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1230230) /Source="Nicolas_upshifts" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1230243..1230250) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1230296..1230982 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YkoH]" /protein_id="NP_389208.1" /db_xref="EnsemblGenomes-Gn:BSU13250" /db_xref="EnsemblGenomes-Tr:CAB13182" /db_xref="GOA:O34903" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13252" /db_xref="UniProtKB/Swiss-Prot:O34903" /translation="MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAA EGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYV TKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPRE FDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHT IRGVGYAIKG*" /label="ykoG CDS" gene 1230296..1230982 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /label="ykoG gene" CDS 1230986..1232350 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YkoG]" /protein_id="NP_389209.1" /db_xref="EnsemblGenomes-Gn:BSU13260" /db_xref="EnsemblGenomes-Tr:CAB13183" /db_xref="GOA:O34638" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13253" /db_xref="UniProtKB/Swiss-Prot:O34638" /translation="MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLAD ETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLS FHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAAS AAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTF NEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIH SEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKE SLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIP HLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQN GGGR*" /label="ykoH CDS" gene 1230986..1232350 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /label="ykoH gene" CDS 1232347..1233027 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295; Product type m : membranecomponent" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389210.1" /db_xref="EnsemblGenomes-Gn:BSU13270" /db_xref="EnsemblGenomes-Tr:CAB13184" /db_xref="GOA:O34551" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13254" /db_xref="UniProtKB/Swiss-Prot:O34551" /translation="MTKTIKTVSFAAAAILVVIICTFLIIRQTHENVLSKETVVKKVE ASYEGKVTKATQSKDKKTYDITLENPKGTYFVKADAISADILSMNRVKAVNPSAMTEK EAEHLALERVPGTVKKQTRQSQVATYTIQKEDGKTYEVKVDMQAKTVLSADQISSKDQ QKTPITKKEAKTIAERKTGGTADDADLEESEGTLIFEVDVDLPDNKEATVKINAYTGK VANIVYED*" /label="ykoI CDS" gene 1232347..1233027 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /label="ykoI gene" promotor_-35 1233056..1233061 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1233077..1233095 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1233080 /Source="Nicolas_upshifts" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1233119..1233631 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17209068; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389211.1" /db_xref="EnsemblGenomes-Gn:BSU13280" /db_xref="EnsemblGenomes-Tr:CAB13185" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13255" /db_xref="UniProtKB/Swiss-Prot:O35012" /translation="MLKKKWMVGLLAGCLAAGGFSYNAFATENNENRQASSKTDALTE QEAEAIAKTVVDGTVEDIDRDLYNGKEVYEVEIEKEGEDYDVYVDIHTKQALNDPLKE KAEQVAITKEEAEEIALKQTGGTVTESKLDEDDGAYIYEMEIQTKQGTETEFEISAKD GRIIKQEIDD*" /label="ykoJ CDS" gene 1233119..1233631 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /label="ykoJ gene" downshifts 1233617 /Source="Nicolas_upshifts" /id="D727" /incds=0 /nref=52 /ntot=228 /MaxReadThrough="3.74302" /MaxDrop="6.03059" /score="28.1760649" /energy="-13.7" /TU="U1070" /idTUdmin="U1070" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 1233662..1233668 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1233682..1233693 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1233683 /Source="Nicolas_upshifts" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1233714..1233851 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389212.1" /db_xref="EnsemblGenomes-Gn:BSU13290" /db_xref="EnsemblGenomes-Tr:CAB13186" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG13332" /db_xref="UniProtKB/Swiss-Prot:O34405" /translation="MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTT E*" /label="ykzD CDS" gene 1233714..1233851 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /label="ykzD gene" downshifts 1233824 /Source="Nicolas_upshifts" /id="D728" /incds=0 /nref=7 /ntot=31 /MaxReadThrough="1.81189" /MaxDrop="3.56977" /score="-4.52149284" /energy="-5.9" /TU="NA" /idTUdmin="U1070" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 1233910..1233917 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1233931..1233950 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1233933..1234252 /Source="Nicolas_S_feature" /locus_tag="new_1395590_1395909" /HighExp="LBGstat, LBGtran, M40t45, MG 25, Mt0, Salt, MG 45, LPhT, BMM, MG t5" /AntisenseName="ykzO" /AntisenseCor="-0.16301119751811899" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S473" upshifts 1233933 /Source="Nicolas_upshifts" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1233965..1234118 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /product="magnesium riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 17803910, 21315082, 28455443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 17803910, 21315082, 28455443; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="swmG RNA" gene 1233965..1234118 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /label="swmG gene" promotor_-35 1234230..1234239 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1234252..1234271 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1234254..1234355 /Source="Nicolas_S_feature" /locus_tag="new_1395911_1396012" /HighExp="LBGstat, LBGtran, M40t45, Mt0, LPhT, Paraq, MG t5, MG 25, MG 60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99773400000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.876, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S474" upshifts 1234254 /Source="Nicolas_upshifts" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" CDS 1234356..1235711 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 22970223, 24415722, 24968120, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 22970223, 24415722, 24968120, 25182490; Product type t : transporter" /codon_start=1 /transl_table=11 /product="magnesium transporter" /protein_id="NP_389213.1" /db_xref="EnsemblGenomes-Gn:BSU13300" /db_xref="EnsemblGenomes-Tr:CAB13187" /db_xref="GOA:O34442" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006667" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR006669" /db_xref="InterPro:IPR036739" /db_xref="SubtiList:BG13256" /db_xref="UniProtKB/Swiss-Prot:O34442" /translation="MVQNMTYDELILRIIILLRDGKIRDFRSVIDELQPYDMAFIFKE MPEKHRARYLSYLTVDDITDMIGELEREFQLVVLNKVGKTKATLAMNKMDNDDLAQLL EEMDEELKEQLLSSMEASESKAVQLLMNYPADSAGRMMTNRYVWIPQHYTVKDAVVKL KSFAEIAESINYLYVINESKQLVGVLSYRDLILGEPEEKVQDLMFTRVISADALQDQE EVARLIERYDFLAIPVVEENNVLVGIVTVDDIIDVVIREADEDYEKFAASGKDITFDT KAYVAAYRRLPWLILLLFIGLISGSIISYFEDALKQVVALAFFMPMVSGMTGNTGTQS LAVVIRGLSKEEMNKKTIVRLIFREFRTSIFIGAVCSVLIAIVSIIWQGNALLGFVVA SSLFLTLIIGTMSGTIIPIILHKLKVDPAIASGPLITTLNDILSLLIYFGIATAFIHS L*" /label="mgtE CDS" gene 1234356..1235711 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /label="mgtE gene" downshifts 1235702 /Source="Nicolas_upshifts" /id="D729" /incds=0 /nref=160 /ntot=239 /MaxReadThrough="1.02063" /MaxDrop="7.38933" /score="-4.14569718" /energy="-8.9" /TU="NA" /idTUdmin="U1072" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1235754..1236086) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen sensing transcriptional regulator" /protein_id="NP_389214.1" /db_xref="EnsemblGenomes-Gn:BSU13310" /db_xref="EnsemblGenomes-Tr:CAB13188" /db_xref="GOA:Q45666" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG11805" /db_xref="UniProtKB/Swiss-Prot:Q45666" /translation="MTTEDHSYKDKKVISIGIVSELTGLSVRQIRYYEERKLIYPQRS SRGTRKYSFADVERLMDIANKREDGVQTAEILKDMRKKEQMLKNDPQVRKKMLEGQLN AHFRYKNR*" /label="tnrA CDS" gene complement(1235754..1236086) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /label="tnrA gene" promotor_-10 complement(1236102..1236121) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1236112) /Source="Nicolas_upshifts" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1236114..1236502) /Source="Nicolas_S_feature" /locus_tag="new_1397771_1398159_c" /HighExp="M9-stat, BC, LoTm, T1.30H, T0.30H, T2.0H, S8, C30, T4.0H, T2.30H" /AntisenseName="ykzB" /AntisenseCor="-3.3870578787867499E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.92" /TUlongSig="NA" /TUlongPSig="NA" /label="S475" promotor_-35 complement(1236137..1236142) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1236174..1236274 /Source="Nicolas_upshift_promotors" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1236234 /Source="Nicolas_upshifts" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="upshifts" CDS 1236281..1236436 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389215.1" /db_xref="EnsemblGenomes-Gn:BSU13320" /db_xref="EnsemblGenomes-Tr:CAB13189" /db_xref="SubtiList:BG13330" /db_xref="UniProtKB/Swiss-Prot:O34923" /translation="MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQN GQYRKSS*" /label="ykzB CDS" gene 1236281..1236436 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /label="ykzB gene" promotor_-35 1236445..1236452 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1236459..1236476 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1236476 /Source="Nicolas_upshifts" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1236487..1236506) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1236502) /Source="Nicolas_upshifts" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1236520..1236526) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1236524..1236706 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389216.1" /db_xref="EnsemblGenomes-Gn:BSU13330" /db_xref="EnsemblGenomes-Tr:CAB13190" /db_xref="SubtiList:BG13257" /db_xref="UniProtKB/Swiss-Prot:O34763" /translation="MSNLLKSALEKERRHYSEKLYQIGVYNKEVMNKMTISELRKEYA YFFRSITNHKNYPYTR*" /label="ykoL CDS" gene 1236524..1236706 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /label="ykoL gene" downshifts 1236674 /Source="Nicolas_upshifts" /id="D730" /incds=0 /nref=2 /ntot=8 /MaxReadThrough="3.83398" /MaxDrop="4.6651" /score="19.6832496" /energy="-11.2" /TU="U1076" /idTUdmin="U1075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1236731..1236739 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1236750..1236768 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1236756..1236838 /Source="Nicolas_S_feature" /locus_tag="new_1398413_1398495" /HighExp="T3.0H, M9-stat, T1.30H, T2.30H, Lbstat, T3.30H, Lbtran, S2, T4.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, Sig-" /TUshortPSig="0.996, 0.00699" /TUlongSig="NA" /TUlongPSig="NA" /label="S476" upshifts 1236756 /Source="Nicolas_upshifts" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" CDS 1236839..1237303 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_389217.1" /db_xref="EnsemblGenomes-Gn:BSU13340" /db_xref="EnsemblGenomes-Tr:CAB13191" /db_xref="GOA:O34949" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13258" /db_xref="UniProtKB/Swiss-Prot:O34949" /translation="MMRLSFNEEEVERAMNLYRVFARAFKSVSEHSIRDSKEHGFNPT EFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAH LTDKGNEYLDKIYPIHALRIARAFSGLSPDEQDQLIVLLKKAGIHSQHLLFR*" /label="ykoM CDS" gene 1236839..1237303 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /label="ykoM gene" downshifts 1237288 /Source="Nicolas_upshifts" /id="D731" /incds=0 /nref=70 /ntot=210 /MaxReadThrough="2.86787" /MaxDrop="5.38705" /score="24.8730632" /energy="-9.8" /TU="U1078" /idTUdmin="U1078" /TUdmin="-112" /isTUend="FALSE" /label="downshifts" CDS complement(1237318..1238439) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389218.2" /db_xref="EnsemblGenomes-Gn:BSU13350" /db_xref="EnsemblGenomes-Tr:CAB13192" /db_xref="GOA:C0SPB9" /db_xref="InterPro:IPR009695" /db_xref="SubtiList:BG13259" /db_xref="UniProtKB/Swiss-Prot:C0SPB9" /translation="MKNILIFPFLSISTGHHHVADALQAELESQGLAAEKIDIFSHSY RRLEKLSSVAYLKWIQYFPKTYSGIYRLLACGEFQHDKRYFMYEWLFTQQMRHILQEK QPDIAFCTHALPSYLLNRLKPEYPNLTVVNVYTDFFVNQLWGRKNIDYHFVPSTEVKK QLISEGIDQNNIYLTGIPVHQNFEMESADTLQHHPPYTIIITGGSMGVGGILKWVQEL SPGGKILYKILCGRNEKLYSYVKSLHHPLIEAIPYLHSKAEMNRLYEQATGIMTKPGG VTISECLQKRLPVFIYHALPGQEEMNLNLLHERKLVTDMRNWDMQKAEEYIAAFFQSN EQMKEYKKHVNGYLGEMSDRKIKDVLKRIIWKQKNTLLK*" /label="ykoN CDS" gene complement(1237318..1238439) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /label="ykoN gene" promotor_-35 1237727..1237735 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1237749..1237768 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1237752..1238530 /Source="Nicolas_S_feature" /locus_tag="new_1399409_1400187" /HighExp="S6, S8, S7, S5, BT, B36, S4, S3, Pyr, G/S" /AntisenseName="ykoN" /AntisenseCor="0.84084970563549499" /AntisenseRegPval="-72.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S477" upshifts 1237752 /Source="Nicolas_upshifts" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1238468..1238479) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1238488) /Source="Nicolas_upshifts" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1238494..1238500) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1238531..1239082 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389219.2" /db_xref="EnsemblGenomes-Gn:BSU13360" /db_xref="EnsemblGenomes-Tr:CAB13193" /db_xref="SubtiList:BG13260" /db_xref="UniProtKB/Swiss-Prot:O34495" /translation="MKTCFLSIWRVVDPIYFFFSRLSLIDNDQKSVFRVRLTKYKGHH VVLSDGTHIRKNDVLVKIHLHNIKLIRELQSIESAVRKGIIIYQKVYQSMPLLLDYIN NHKKSEKIKGIIGITMLDKGVERLGFDVITPVNPFYRCFKKVSHVPILYLTSKPVSLR HLPNSSYLFISKEKLQKTYQKKD*" /label="ykoP CDS" gene 1238531..1239082 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /label="ykoP gene" downshifts 1239050 /Source="Nicolas_upshifts" /id="D732" /incds=0 /nref=4 /ntot=25 /MaxReadThrough="3.31887" /MaxDrop="3.7149" /score="-2.92393792" /energy="-7" /TU="U1079" /idTUdmin="U1079" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(1239110..1239922) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metallophosphoesterase" /protein_id="NP_389220.1" /db_xref="EnsemblGenomes-Gn:BSU13370" /db_xref="EnsemblGenomes-Tr:CAB13194" /db_xref="GOA:O35040" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13261" /db_xref="UniProtKB/Swiss-Prot:O35040" /translation="MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARK KLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQ KLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGI DDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKP YHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI*" /label="ykoQ CDS" gene complement(1239110..1239922) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /label="ykoQ gene" promotor_-10 complement(1239882..1239901) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1239896) /Source="Nicolas_upshifts" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1239915..1239920) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1240023..1240029 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1240040..1240114 /Source="Nicolas_S_feature" /locus_tag="new_1401697_1401771" /HighExp="S5, S6, S7, S4, S8, T5.0H, ferm, nit, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S478" upshifts 1240040 /Source="Nicolas_upshifts" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1240043..1240054 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1240115..1241809 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389221.1" /db_xref="EnsemblGenomes-Gn:BSU13380" /db_xref="EnsemblGenomes-Tr:CAB13195" /db_xref="GOA:O34830" /db_xref="SubtiList:BG13262" /db_xref="UniProtKB/Swiss-Prot:O34830" /translation="MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNL DSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAI SQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLAL WAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFL GSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHV MTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPK QKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPF NEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTL DTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSK KTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR*" /label="ykoS CDS" gene 1240115..1241809 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /label="ykoS gene" CDS 1241822..1242835 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /EC_number="2.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389222.1" /db_xref="EnsemblGenomes-Gn:BSU13390" /db_xref="EnsemblGenomes-Tr:CAB13196" /db_xref="GOA:O34755" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13263" /db_xref="UniProtKB/Swiss-Prot:O34755" /translation="MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAED SKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVI SIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIK LIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYP LKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLI ISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEK KYS*" /label="ykoT CDS" gene 1241822..1242835 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /label="ykoT gene" downshifts 1242820 /Source="Nicolas_upshifts" /id="D733" /incds=0 /nref=13 /ntot=35 /MaxReadThrough="0.53349" /MaxDrop="4.80671" /score="19.4012674" /energy="-13.7" /TU="NA" /idTUdmin="U1082" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(1242861..1244696) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /EC_number="6.5.1.1" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12215643, 16497325, 17293412, 23691176, 25355514, 26826709" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12215643, 16497325, 17293412, 23691176, 25355514, 26826709; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit; 5'-2-deoxyribose-5-phosphate (dRP) lyase" /protein_id="NP_389223.1" /db_xref="EnsemblGenomes-Gn:BSU13400" /db_xref="EnsemblGenomes-Tr:CAB13197" /db_xref="GOA:O34398" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR014143" /db_xref="InterPro:IPR014145" /db_xref="InterPro:IPR014146" /db_xref="InterPro:IPR033652" /db_xref="SubtiList:BG13264" /db_xref="UniProtKB/Swiss-Prot:O34398" /translation="MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSR NGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRP DKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKE TIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCIT GFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPS ICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIF EKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQ SFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLM AVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTN AFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSS LTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS*" /label="ligD CDS" gene complement(1242861..1244696) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /label="ligD gene" downshifts complement(1242910) /Source="Nicolas_upshifts" /id="D734" /incds=0 /nref=10 /ntot=54 /MaxReadThrough="0.67916" /MaxDrop="5.08051" /score="-8.48510187" /energy="-13.7" /TU="NA" /idTUdmin="U1083" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1244700..1245635) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11095673, 12215643, 16497325, 16780573, 23691176, 25355514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11095673, 12215643, 16497325, 16780573, 23691176, 25355514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit Ku; AP/deoxyribose 5'-phosphate (5'-dRP)-lyase" /protein_id="NP_389224.1" /db_xref="EnsemblGenomes-Gn:BSU13410" /db_xref="EnsemblGenomes-Tr:CAB13198" /db_xref="GOA:O34859" /db_xref="InterPro:IPR006164" /db_xref="InterPro:IPR009187" /db_xref="InterPro:IPR016194" /db_xref="SubtiList:BG13265" /db_xref="UniProtKB/Swiss-Prot:O34859" /translation="MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDK DIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQE HEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTI RSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELT AKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRR PNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS*" /label="ligV CDS" gene complement(1244700..1245635) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /label="ligV gene" promotor_-10 complement(1245606..1245617) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1245616) /Source="Nicolas_upshifts" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1245632..1245638) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1245672..1248074) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11728710, 17010156, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11728710, 17010156, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="YP_054577.2" /db_xref="EnsemblGenomes-Gn:BSU13420" /db_xref="EnsemblGenomes-Tr:CAB13199" /db_xref="GOA:O34311" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR005330" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR035919" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG13266" /db_xref="UniProtKB/Swiss-Prot:O34311" /translation="MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIW LIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHI LTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIF FDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHW SIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGD IISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFH LNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTK VLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARL GGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTD GLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQ PQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQAR IWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNH SKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQIT GAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQP SQ*" /label="dgcW CDS" gene complement(1245672..1248074) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /label="dgcW gene" downshifts complement(1245704) /Source="Nicolas_upshifts" /id="D735" /incds=0 /nref=13 /ntot=101 /MaxReadThrough="1.93589" /MaxDrop="3.26543" /score="6.55794882" /energy="-9" /TU="NA" /idTUdmin="U1084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1247922..1248124) /Source="Nicolas_S_feature" /locus_tag="new_1409579_1409781_c" /HighExp="Cold, GM 25, GM 10, GM 45, GM 15, GM-0.2, GM-0.1, GM 5, GM 90, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S479" promotor_-10 complement(1248113..1248131) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1248124) /Source="Nicolas_upshifts" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1248145..1248152) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1248191..1248198 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1248212..1248231 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1248224 /Source="Nicolas_upshifts" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="upshifts" CDS 1248255..1248920 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23687963; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389226.1" /db_xref="EnsemblGenomes-Gn:BSU13430" /db_xref="EnsemblGenomes-Tr:CAB13200" /db_xref="GOA:O34908" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13267" /db_xref="UniProtKB/Swiss-Prot:O34908" /translation="MIHKHETRELVAIEELVMSWIEAFKSLSYFGIFLALSIEFIPAE VVLPLAGYWVSKGDMTLAGVVLAGSLGGVAGPLTLYWIGRYGGRPFLERFGKYLFIKP EALDKSDNFFKKHGGFVAFSGRFLPGIRTLISIPCGIAKMNVWVFSLYTFIAMLPITF VYVYLGVKLGENWKAVGSILDQYMLPIGIAILALFLLYLLMKKRKKRTHSEQLSVFLK NKR*" /label="ykoX CDS" gene 1248255..1248920 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /label="ykoX gene" promotor_-10 complement(1248789..1248808) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1248806) /Source="Nicolas_upshifts" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1248822..1248831) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1248915..1248922 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1248937..1248956 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1248950 /Source="Nicolas_upshifts" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1248976..1249109 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /product="manganese ion riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="mnrW RNA" gene 1248976..1249109 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /label="mnrW gene" CDS 1248997..1249971 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 15849754, 16850406, 25794618, 25794619; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative manganese-related ion transporter" /protein_id="NP_389227.1" /db_xref="EnsemblGenomes-Gn:BSU13440" /db_xref="EnsemblGenomes-Tr:CAB13201" /db_xref="GOA:O34997" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13268" /db_xref="UniProtKB/Swiss-Prot:O34997" /translation="MYSGNKVVISWIVSIGFVGMPEFMSSKTFALCRQRSFLHGPAGI RSDEEKENNFFGRVSFMDAALLLEYGWVLLVLIGLEGILAADNALVMAVMVKHLPEEK RKKALFYGLAGAFVLRFGSLFAISFLVNVWQVQAIGAIYLLYISASHLLKRYVFKKED THKETKQSGFWPTVLKVELADIAFAVDSILAAVALAVTLPGTSLPKIGGLDGGQFLVI LAGGIIGLVIMRFAASMFVKLLKERPSLETAAFVIVGWVGVKLALYTLAHRDIAVVSE HFIHSGTWKLIFWGVLAAIAVCGWFMSGGKKQPEGAQNEQKNSTRERA*" /label="ykoY CDS" gene 1248997..1249971 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /label="ykoY gene" downshifts 1249060 /Source="Nicolas_upshifts" /id="D736" /incds=1 /nref=38 /ntot=211 /MaxReadThrough="5.00041" /MaxDrop="4.46498" /score="15.8563987" /energy="-15" /TU="U1085,U1087" /idTUdmin="U1085" /TUdmin="-902" /isTUend="FALSE" /label="downshifts" downshifts 1249959 /Source="Nicolas_upshifts" /id="D737" /incds=0 /nref=16 /ntot=175 /MaxReadThrough="2.59801" /MaxDrop="4.20782" /score="24.4740487" /energy="-13.7" /TU="NA" /idTUdmin="U1085" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1250081..1250089 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1250103..1250111 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1250113 /Source="Nicolas_upshifts" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="upshifts" S_feature 1250116..1250202 /Source="Nicolas_S_feature" /locus_tag="new_1411773_1411859" /HighExp="M9-stat, T1.30H, T1.0H, T0.30H, T2.0H, T2.30H, HiTm, M0t90, T3.0H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29969800000000002" /TUshortSig="SigI" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S480" promotor_-35 1250175..1250182 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1250196..1250215 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1250204 /Source="Nicolas_upshifts" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="upshifts" CDS 1250235..1250990 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma factor (heat stress responsive)" /protein_id="NP_389228.1" /db_xref="EnsemblGenomes-Gn:BSU13450" /db_xref="EnsemblGenomes-Tr:CAB13218" /db_xref="GOA:O31654" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG13269" /db_xref="UniProtKB/Swiss-Prot:O31654" /translation="MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFI AKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIR KEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDY GLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRK TIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS*" /label="sigI CDS" gene 1250235..1250990 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /label="sigI gene" CDS 1250987..1252132 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17185538, 23199363, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17185538, 23199363, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="sigmaI modulating factor" /protein_id="NP_389229.1" /db_xref="EnsemblGenomes-Gn:BSU13460" /db_xref="EnsemblGenomes-Tr:CAB13219" /db_xref="GOA:O31655" /db_xref="InterPro:IPR024449" /db_xref="SubtiList:BG13272" /db_xref="UniProtKB/Swiss-Prot:O31655" /translation="MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSE TRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEM ALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILI STVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIK SNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQK EEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYH RDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE*" /label="rsgI CDS" gene 1250987..1252132 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /label="rsgI gene" S_feature 1252133..1253292 /Source="Nicolas_S_feature" /locus_tag="new_1413790_1414949" /HighExp="HiTm, G135, G180, C30, G150, Cold, S8, MG 25, H2O2, Lbstat" /AntisenseName="ykrK" /AntisenseCor="0.122248209149143" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigI" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S481" CDS complement(1252143..1252337) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:3009397, 3112127, 3121585, 9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009397, 3112127, 3121585, 9852018; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_389230.1" /db_xref="EnsemblGenomes-Gn:BSU13470" /db_xref="EnsemblGenomes-Tr:CAB13220" /db_xref="GOA:P04833" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10788" /db_xref="UniProtKB/Swiss-Prot:P04833" /translation="MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVG GEMTKRLVQQAQSQLNGTTK*" /label="sspD CDS" gene complement(1252143..1252337) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /label="sspD gene" downshifts complement(1252150) /Source="Nicolas_upshifts" /id="D738" /incds=0 /nref=24 /ntot=36 /MaxReadThrough="1.67859" /MaxDrop="4.68215" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1090" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1252380..1252391) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1252390) /Source="Nicolas_upshifts" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1252406..1252412) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1252468..1253169) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22447908, 23042994" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22447908, 23042994; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of quality control" /protein_id="NP_389231.1" /db_xref="EnsemblGenomes-Gn:BSU13480" /db_xref="EnsemblGenomes-Tr:CAB13221" /db_xref="InterPro:IPR014975" /db_xref="SubtiList:BG13273" /db_xref="UniProtKB/Swiss-Prot:O31656" /translation="MNIFKLSRTDMVRLLYSLKGQGEHSPLDILVQSANMSAEKAANH LEIPEFLTRYERKKQKKEYGLSTNEIVELGNLCELTSLKSTAIQNWVKRDIKDLIGHP ELGKKYSIEQAVILLIVRDLKSIYDFEHIRAILKVAFNTISDRSDDVISPIAYYESCA YVLDAIHHQDTPSMKESNLQEIAEQETERLRHRFEELNDSQWLKIRQIIAITVLSILT FHIQATAHKMTADIL*" /label="htpK CDS" gene complement(1252468..1253169) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /label="htpK gene" downshifts complement(1252502) /Source="Nicolas_upshifts" /id="D739" /incds=0 /nref=174 /ntot=231 /MaxReadThrough="2.96889" /MaxDrop="5.30355" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1253170..1253250) /Source="Nicolas_S_feature" /locus_tag="new_1414827_1414907_c" /HighExp="LBGtran, dia0, LBGexp, Lbexp, Oxctl, G180, M0t45, C90, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S482" promotor_-10 complement(1253242..1253261) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1253250) /Source="Nicolas_upshifts" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1253266..1253273 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1253275..1253282) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1253287..1253306 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1253294 /Source="Nicolas_upshifts" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="upshifts" CDS 1253340..1254236 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11860552, 12081643, 16076848, 16573693, 22447908, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane protease" /protein_id="NP_389232.1" /db_xref="EnsemblGenomes-Gn:BSU13490" /db_xref="EnsemblGenomes-Tr:CAB13222" /db_xref="GOA:O31657" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR022919" /db_xref="SubtiList:BG13274" /db_xref="UniProtKB/Swiss-Prot:O31657" /translation="MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDP MALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSR SAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILG SLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGK KRSSLFSTHPDLDERIRRLEAK*" /label="htpX CDS" gene 1253340..1254236 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /label="htpX gene" downshifts 1254230 /Source="Nicolas_upshifts" /id="D740" /incds=0 /nref=203 /ntot=268 /MaxReadThrough="3.02778" /MaxDrop="6.27746" /score="38.5173589" /energy="-13.4" /TU="NA" /idTUdmin="U1092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1254341..1254345 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1254361..1254380 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1254365 /Source="Nicolas_upshifts" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="upshifts" CDS 1254410..1255759 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /EC_number="3.6.3.12" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 23963175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 23963175; Product type t : transporter" /codon_start=1 /transl_table=11 /product="K+-transporting ATPase" /protein_id="NP_389233.1" /db_xref="EnsemblGenomes-Gn:BSU13500" /db_xref="EnsemblGenomes-Tr:CAB13223" /db_xref="GOA:O31658" /db_xref="InterPro:IPR003445" /db_xref="SubtiList:BG13275" /db_xref="UniProtKB/Swiss-Prot:O31658" /translation="MRLKFGKLIQALSPAQLIALYYFLAVTVAVILLSLPAAHKPGAD WTFIDALFTAVSSVSVTGLTVVDTADTFSTIGIFILAFVLQFGGIGIMTLGTFIWLIM GKRIGLKERKLIMVDQNQSQFSGIVNLMKQVLFLILWIEFFGGLILGTYFLTYYDSYQ EAYLHGFFASISATTNGGFDITGNSMIPFRHDYFVQFITMLLIIFGAIGFPVLVEVKD FLFSKHRRYPFTLFTKITTITFGSLVLFGAIGIFALEANHAFAGKSWHDILFLSLFQS TATRSGGLATIDISQLSDSTLFFICALMFIGASPSSVGGGIRTTTFALNLLALFHFAR GNKAVKVFKRELHPADLMKSLVVTMMAILLVFGATLILTITEKHSLLELLFEVCSAFG TTGLSLGITADLSSVGKCVIMIVMFIGRIGILTFLYLIGRKEIEANYHYPKERVIIG* " /label="ktrD CDS" gene 1254410..1255759 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /label="ktrD gene" downshifts 1255747 /Source="Nicolas_upshifts" /id="D741" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="0.838800000000001" /MaxDrop="4.37717" /score="20.0478288" /energy="-10.7" /TU="NA" /idTUdmin="U1093" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1255808..1255814 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1255828..1255839 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1255836..1255903 /Source="Nicolas_S_feature" /locus_tag="new_1417493_1417560" /HighExp="S8, S6, S7, S5, ferm, nit, BT, B36, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S483" upshifts 1255836 /Source="Nicolas_upshifts" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1255904..1256059 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097718.1" /db_xref="EnsemblGenomes-Gn:BSU13509" /db_xref="EnsemblGenomes-Tr:CAX52609" /db_xref="UniProtKB/Swiss-Prot:C0H402" /translation="MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSK QGQQGGM*" /label="ykzP CDS" gene 1255904..1256059 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /label="ykzP gene" CDS 1256062..1256238 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389234.1" /db_xref="EnsemblGenomes-Gn:BSU13510" /db_xref="EnsemblGenomes-Tr:CAB13224" /db_xref="SubtiList:BG13333" /db_xref="UniProtKB/Swiss-Prot:O31659" /translation="MKKNRHSRDMQNHKKPMNKKVLEEEFSSELGDYNAGKIIETLEV TKPEKKKEKNKKQQ*" /label="ykzE CDS" gene 1256062..1256238 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /label="ykzE gene" promotor_no_box 1256128..1256228 /Source="Nicolas_upshift_promotors" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1256188 /Source="Nicolas_upshifts" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1256234 /Source="Nicolas_upshifts" /id="D742" /incds=0 /nref=56 /ntot=112 /MaxReadThrough="2.40289" /MaxDrop="8.38761" /score="26.5107018" /energy="-19.7" /TU="NA" /idTUdmin="U1094" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1256281..1257303) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /EC_number="2.3.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral membrane protein; putative acyltransferase" /protein_id="NP_389235.1" /db_xref="EnsemblGenomes-Gn:BSU13520" /db_xref="EnsemblGenomes-Tr:CAB13225" /db_xref="GOA:O31660" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG13276" /db_xref="UniProtKB/Swiss-Prot:O31660" /translation="MSKSRDSYFDNAKFLLIFLVVFGHILRSFINDNHFMLYLYKFIY TFHMPAFILVSGYFAKGFKRAGYVKKLAVKLIIPYLIFQIIYSVFYYIMQDESMANVN PIDPQWSLWFLVSLFFWNLLLYPFSKLSKQWALFVSCGIAVLIGYLDFVSSTLSLSRT FVFLPMFLVGFYLNKHHFDLLRSKRGKQIALGVLAAVFVICWGIDFDYSFLFGSKPYS SFGDVTLVSGLSRIGWYVLAFGATFSFLALVPQKRYFFTKWGTRTFYVYLLHGFIIKT LRQVGLEDWLTDYQSLVILLLLTAALTSVLSSNFVKTVAQPFIELRMTSLLQFVRGTG KNAYLK*" /label="ykrP CDS" gene complement(1256281..1257303) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /label="ykrP gene" downshifts complement(1256304) /Source="Nicolas_upshifts" /id="D743" /incds=0 /nref=11 /ntot=58 /MaxReadThrough="2.29259" /MaxDrop="3.64731" /score="30.4184602" /energy="-16.9" /TU="NA" /idTUdmin="U1096" /TUdmin=92 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1257348..1257367) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1257364) /Source="Nicolas_upshifts" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1257379..1257385) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1257492..1257500 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1257508 /Source="Nicolas_upshifts" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1257511..1257529 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1257556..1259772 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11069677, 12169614, 16166384, 25701730" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 12169614, 16166384, 25701730; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_389236.1" /db_xref="EnsemblGenomes-Gn:BSU13530" /db_xref="EnsemblGenomes-Tr:CAB13226" /db_xref="GOA:O31661" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13277" /db_xref="UniProtKB/Swiss-Prot:O31661" /translation="METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAI FICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLW KEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDR AVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNR KGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFR EIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKR KYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESE LKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENL ASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERL RKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIES IITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEP NQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEP FYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE*" /label="kinE CDS" gene 1257556..1259772 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /label="kinE gene" S_feature complement(1259547..1260487) /Source="Nicolas_S_feature" /locus_tag="new_1421204_1422144_c" /HighExp="Pyr, Glucon, C30, Glu, Mal, M/G, G/S, Heat, Fru, B36" /AntisenseName="ogt" /AntisenseCor="-0.33210294457391598" /AntisenseRegPval="-7.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S484" promotor_-35 1259625..1259632 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1259647..1259666 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1259649 /Source="Nicolas_upshifts" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="upshifts" CDS 1259769..1260266 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2105461, 2308822, 2359121, 2506524, 7565865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105461, 2308822, 2359121, 2506524, 7565865; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-alkylguanine DNA alkyltransferase" /protein_id="NP_389237.1" /db_xref="EnsemblGenomes-Gn:BSU13540" /db_xref="EnsemblGenomes-Tr:CAB13227" /db_xref="GOA:P11742" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR023546" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10848" /db_xref="UniProtKB/Swiss-Prot:P11742" /translation="MNYYTTAETPLGELIIAEEEDRITRLFLSQEDWVDWKETVQNTE HKETPNLAEAKQQLQEYFAGERKTFSLPLSQKGTPFQQKVWQALERIPYGESRSYADI AAAVGSPKAVRAVGQANKRNDLPIFVPCHRVIGKNSALTGYAGSKTEIKAFLLNIERI SYKEK*" /label="ogt CDS" gene 1259769..1260266 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /label="ogt gene" S_feature 1260267..1260506 /Source="Nicolas_S_feature" /locus_tag="new_1421924_1422163" /HighExp="Lbstat, S2, BT, BC, LPhT, dia15, LBGstat, M0t90, M9-stat, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.981549" /TUshortSig="SigA, SigH" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S485" CDS 1260356..1260481 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513954.1" /translation="MKPSRSEKLAVFAELFVKLHILSSAQKDEIINVNKKKQKNR*" /label="hypothetical protein CDS" gene 1260356..1260481 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /label="gene" downshifts 1260474 /Source="Nicolas_upshifts" /id="D744" /incds=0 /nref=80 /ntot=239 /MaxReadThrough="1.90528" /MaxDrop="5.2481" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1260515..1261576) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /EC_number="5.3.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14551435, 15102328, 16511105, 17690466, 18156470" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14551435, 15102328, 16511105, 17690466, 18156470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose-1-phosphate isomerase (methionine salvage pathway)" /protein_id="NP_389238.1" /db_xref="EnsemblGenomes-Gn:BSU13550" /db_xref="EnsemblGenomes-Tr:CAB13228" /db_xref="GOA:O31662" /db_xref="InterPro:IPR000649" /db_xref="InterPro:IPR005251" /db_xref="InterPro:IPR011559" /db_xref="InterPro:IPR027363" /db_xref="PDB:2YRF" /db_xref="PDB:2YVK" /db_xref="SubtiList:BG13278" /db_xref="UniProtKB/Swiss-Prot:O31662" /translation="MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDA IVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSW ALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTIC NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLI TDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLST FDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGI MTGNYEEEIEQLFKGEKVH*" /label="mtnA CDS" gene complement(1260515..1261576) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /label="mtnA gene" downshifts complement(1260532) /Source="Nicolas_upshifts" /id="D745" /incds=0 /nref=261 /ntot=286 /MaxReadThrough="4.47312" /MaxDrop="7.97339" /score="34.04363" /energy="-17.1" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(1261584..1262777) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /EC_number="2.7.1.100" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:210167, 11545674, 15102328, 17522047, 23649237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 210167, 11545674, 15102328, 17522047, 23649237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose kinase (methionine salvage pathway, promiscuous)" /protein_id="NP_389239.2" /db_xref="EnsemblGenomes-Gn:BSU13560" /db_xref="EnsemblGenomes-Tr:CAB13229" /db_xref="GOA:O31663" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR009212" /db_xref="InterPro:IPR011009" /db_xref="PDB:2OLC" /db_xref="PDB:2PU8" /db_xref="PDB:2PUI" /db_xref="PDB:2PUL" /db_xref="PDB:2PUN" /db_xref="PDB:2PUP" /db_xref="SubtiList:BG13279" /db_xref="UniProtKB/Swiss-Prot:O31663" /translation="MGVTKTPLYETLNESSAVALAVKLGLFPSKSTLTCQEIGDGNLN YVFHIYDQEHDRALIIKQAVPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPRV FYSDTEMAVTVMEDLSHLKIARKGLIEGENYPHLSQHIGEFLGKTLFYSSDYALEPKV KKQLVKQFTNPELCDITERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKL KKSFLTSAETLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALS RDGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFEEAIGFA GCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKRSEFKTITDVIELFK LLVKE*" /label="mtnK CDS" gene complement(1261584..1262777) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /label="mtnK gene" downshifts 1261644 /Source="Nicolas_upshifts" /id="D746" /incds=1 /nref=1 /ntot=51 /MaxReadThrough="3.02938" /MaxDrop="3.49719" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts complement(1262864) /Source="Nicolas_upshifts" /id="D747" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="8.61071" /MaxDrop="3.05641" /score="27.7981655" /energy="-17.6" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-2750" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1262870..1263026) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="12: Regulatory functions" /label="mswC RNA" gene complement(1262870..1263026) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /label="mswC gene" promotor_-10 complement(1263061..1263080) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1263062) /Source="Nicolas_upshifts" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1263096..1263103) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1263106..1263109 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1263110..1263889) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /EC_number="3.5.1.3" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12022921, 19464248, 19596042, 21288482, 23944997, 24387040; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ketoglutaramate omega-amidase" /protein_id="NP_389240.1" /db_xref="EnsemblGenomes-Gn:BSU13570" /db_xref="EnsemblGenomes-Tr:CAB13230" /db_xref="GOA:O31664" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG13280" /db_xref="UniProtKB/Swiss-Prot:O31664" /translation="MKWTISCLQFDISYGKPSENIKKAEFFIEKESKHADVLVLPELW TTGYDLANLDELADEDGRSAQSWLKKTAKKHGVHIVAGSVAVRKNSDVYNTMYIADKE GQIIKEYRKAHLFQLMDEHLYLSAGSEDGYFELDGVKSSGLICYDIRFPEWIRKHTTK GANVLFISAEWPLPRLDHWKSLLIARAIENQCFVAACNCTGSNPDNEFAGHSLIIDPW GRVLAEGGREEGIVRAEIDLQESAEVRESIPVFDDIRKDLY*" /label="mtnU CDS" gene complement(1263110..1263889) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /label="mtnU gene" promotor_-10 1263125..1263144 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1263134 /Source="Nicolas_upshifts" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1263582..1263589 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-35" promotor_-10 1263602..1263621 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-10" upshifts 1263617 /Source="Nicolas_upshifts" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="upshifts" S_feature 1263624..1263941 /Source="Nicolas_S_feature" /locus_tag="new_1425281_1425598" /HighExp="LoTm, S8, C30, BC, S7, B36, B60, T2.0H, Sw, UNK1" /AntisenseName="mtnU" /AntisenseCor="0.77659263363209297" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S486" promotor_-35 1263911..1263918 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1263919..1263938) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1263933..1263952 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1263933) /Source="Nicolas_upshifts" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" upshifts 1263943 /Source="Nicolas_upshifts" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1263954..1263961) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1263984..1265180 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /EC_number="2.6.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15102328, 23429746, 24387040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15102328, 23429746, 24387040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine-glutamine aminotransferase" /protein_id="NP_389241.1" /db_xref="EnsemblGenomes-Gn:BSU13580" /db_xref="EnsemblGenomes-Tr:CAB13231" /db_xref="GOA:O31665" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13281" /db_xref="UniProtKB/Swiss-Prot:O31665" /translation="MKFEQSHVLKELPKQFFASLVQKVNRKLAEGHDVINLGQGNPDQ PTPEHIVEEMKRAVADPENHKYSSFRGSYRLKSAAAAFYKREYGIDLDPETEVAVLFG GKAGLVELPQCLLNPGDTILVPDPGYPDYWSGVTLAKAKMEMMPLVKDRAFLPDYSSI TAEIREQAKLMYLNYPNNPTGAVATSEFFEDTVRFAAENGICVVHDFAYGAVGFDGCK PLSFLQTEGAKDIGIEIYTLSKTYNMAGWRVGFAVGNASVIEAINLYQDHMFVSLFRA TQEAAAEALLADQTCVAEQNARYESRRNAWITACREIGWDVTAPAGSFFAWLPVPEGY TSEQFSDLLLEKANVAVAAGNGFGEYGEGYVRVGLLTSEERLKEAAYRIGKLNLFTQK SIDKTL*" /label="mtnE CDS" gene 1263984..1265180 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /label="mtnE gene" promotor_-35 1265162..1265169 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1265184..1265203 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1265203 /Source="Nicolas_upshifts" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1265219..1265319 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="16.3: Control" /label="mswD RNA" gene 1265219..1265319 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /label="mswD gene" downshifts 1265318 /Source="Nicolas_upshifts" /id="D748" /incds=0 /nref=49 /ntot=190 /MaxReadThrough="7.27369" /MaxDrop="4.19981" /score="-1.80590532" /energy="-10.7" /TU="U1103,U1104" /idTUdmin="U1101" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS 1265404..1266621 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /EC_number="5.3.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 16737967, 18403380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 16737967, 18403380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase)" /protein_id="NP_389242.2" /db_xref="EnsemblGenomes-Gn:BSU13590" /db_xref="EnsemblGenomes-Tr:CAB13232" /db_xref="GOA:O31666" /db_xref="InterPro:IPR000685" /db_xref="InterPro:IPR017443" /db_xref="InterPro:IPR017717" /db_xref="InterPro:IPR033966" /db_xref="InterPro:IPR036376" /db_xref="InterPro:IPR036422" /db_xref="PDB:2ZVI" /db_xref="SubtiList:BG13282" /db_xref="UniProtKB/Swiss-Prot:O31666" /translation="MSELLATYLLTEPGADTEKKAEQIATGLTVGSWTDLPLVKQEQM QKHKGRVIKVEEREGTAASEKQAVITIAYPEINFSQDIPALLTTVFGKLSLDGKIKLI DLHFSEAFKRALPGPKFGVYGIRKLLGEFERPLLMSIFKGVIGRDLSDIKEQLRQQAL GGVDLIKDDEIFFETGLAPFETRIAEGKQILKETYEQTGHKTLYAVNLTGRTADLKDK ARRAAELGADALLFNVFAYGLDVMQGLAEDPEIPVPIMAHPAVSGAFTSSPFYGFSHA LLLGKLNRYCGADFSLFPSPYGSVALPRADALAIHEECVREDAFNQTFAVPSAGIHPG MVPLLMRDFGIDHIINAGGGVHGHPNGAQGGGRAFRAIIDAVLEAQPIDEKAEQCKDL KLALDKWGKAEAV*" /label="mtnW CDS" gene 1265404..1266621 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /label="mtnW gene" CDS 1266618..1267325 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /EC_number="3.1.3.87" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 17654724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 17654724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphatephosphatase (HK-MTPenyl-1-P phosphatase)" /protein_id="NP_389243.1" /db_xref="EnsemblGenomes-Gn:BSU13600" /db_xref="EnsemblGenomes-Tr:CAB13233" /db_xref="GOA:O31667" /db_xref="InterPro:IPR006384" /db_xref="InterPro:IPR017718" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:2FEA" /db_xref="SubtiList:BG13283" /db_xref="UniProtKB/Swiss-Prot:O31667" /translation="MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSK TLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGM DFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSE PNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVK EVQEWLQNKNAGESSLK*" /label="mtnX CDS" gene 1266618..1267325 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /label="mtnX gene" CDS 1267283..1267912 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /EC_number="4.2.1.109" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 18391471, 23285211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 18391471, 23285211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)" /protein_id="NP_389244.1" /db_xref="EnsemblGenomes-Gn:BSU13610" /db_xref="EnsemblGenomes-Tr:CAB13234" /db_xref="GOA:O31668" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR017714" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG13284" /db_xref="UniProtKB/Swiss-Prot:O31668" /translation="MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLV TASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTV NNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEIS EDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK*" /label="mtnB CDS" gene 1267283..1267912 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /label="mtnB gene" CDS 1267927..1268463 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acireductone dioxygenase (Ni2+ or Fe2+-requiring)" /protein_id="NP_389245.1" /db_xref="EnsemblGenomes-Gn:BSU13620" /db_xref="EnsemblGenomes-Tr:CAB13235" /db_xref="GOA:O31669" /db_xref="InterPro:IPR004313" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR023956" /db_xref="SubtiList:BG13285" /db_xref="UniProtKB/Swiss-Prot:O31669" /translation="MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLS EKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHH TDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRI FVTTEGWVPIYEKDSVNQ*" /label="mtnD CDS" gene 1267927..1268463 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /label="mtnD gene" S_feature complement(1268310..1268503) /Source="Nicolas_S_feature" /locus_tag="new_1429967_1430160_c" /HighExp="Lbstat, Cold, LBGstat, T0.30H, M9-stat, B60, ferm, T1.30H, LPhT, M0t90" /AntisenseName="mtnD" /AntisenseCor="-0.31139057410816301" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S487" downshifts 1268463 /Source="Nicolas_upshifts" /id="D749" /incds=0 /nref=179 /ntot=227 /MaxReadThrough="1.58976" /MaxDrop="6.10661" /score="35.4563733" /energy="-14.9" /TU="NA" /idTUdmin="U1103" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1268504..1268824) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389246.1" /db_xref="EnsemblGenomes-Gn:BSU13630" /db_xref="EnsemblGenomes-Tr:CAB13236" /db_xref="GOA:O31670" /db_xref="InterPro:IPR010652" /db_xref="SubtiList:BG13308" /db_xref="UniProtKB/Swiss-Prot:O31670" /translation="MKKKKAIMLGAAGGKAILKRKNRKKCIQHITTFFQMLRDWRNGD YPRSQVKTLLLLTAAILYIVMPLDIIPDVILGLGFIDDAAVLGLIWTLIKKELSQYEK WRLQ*" /label="ykvA CDS" gene complement(1268504..1268824) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /label="ykvA gene" downshifts complement(1268562) /Source="Nicolas_upshifts" /id="D750" /incds=0 /nref=5 /ntot=148 /MaxReadThrough="4.05831" /MaxDrop="2.74575" /score="18.5455371" /energy="-11.3" /TU="U1106" /idTUdmin="U1106" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(1268825..1268914) /Source="Nicolas_S_feature" /locus_tag="new_1430482_1430571_c" /HighExp="Lbstat, M9-stat, B60, T0.30H, LBGstat, M0t90, T1.0H, S2, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S488" promotor_-35 1268850..1268856 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1268871..1268889 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1268881 /Source="Nicolas_upshifts" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" S_feature 1268882..1268966 /Source="Nicolas_S_feature" /locus_tag="new_1430539_1430623" /HighExp="Etha, Gly, BC, Salt, Sw, B60, LoTm, M9-stat, LPhT, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S489" promotor_-10 complement(1268896..1268915) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1268913) /Source="Nicolas_upshifts" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1268930..1268933) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1268940..1268947 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1268962..1268981 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1268968..1269026 /Source="Nicolas_S_feature" /locus_tag="new_1430625_1430683" /HighExp="Etha, Gly, Sw, BC, LoTm, B36, T3.30H, Salt, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S490" upshifts 1268968 /Source="Nicolas_upshifts" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1269024) /Source="Nicolas_upshifts" /id="D751" /incds=0 /nref=3 /ntot=61 /MaxReadThrough="0.87927" /MaxDrop="3.53961" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1106" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1269027..1269284 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15057450, 15916600, 17001075, 19332814, 22524514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15057450, 15916600, 17001075, 19332814, 22524514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="negative regulatory phosphatase acting on Spo0A-P (sporulation)" /protein_id="NP_389247.1" /db_xref="EnsemblGenomes-Gn:BSU13640" /db_xref="EnsemblGenomes-Tr:CAB13237" /db_xref="GOA:P05043" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG10769" /db_xref="UniProtKB/Swiss-Prot:P05043" /translation="MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDC LINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK*" /label="spo0E CDS" gene 1269027..1269284 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /label="spo0E gene" downshifts 1269278 /Source="Nicolas_upshifts" /id="D752" /incds=0 /nref=7 /ntot=169 /MaxReadThrough="4.39402" /MaxDrop="3.59614" /score="0.224700481" /energy="-5.9" /TU="U1105,U1107" /idTUdmin="U1105" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS 1269370..1269801 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative small membrane protein" /protein_id="NP_389248.1" /db_xref="EnsemblGenomes-Gn:BSU13650" /db_xref="EnsemblGenomes-Tr:CAB13238" /db_xref="GOA:P06630" /db_xref="SubtiList:BG10770" /db_xref="UniProtKB/Swiss-Prot:P06630" /translation="MKELAILITEMVNQFHDAFISLCGIFGIHLTDKEMHFWVIGIFG IFFFGVTHAVFTWLSKWSMTALSFIYTVTVIIVIVFAIEIQQKVTGRGNMEFLDATEG IKGFLVFFMFFLLLKMLLRFIKILFSGRPASKSNGNARSRR*" /label="eag CDS" gene 1269370..1269801 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /label="eag gene" CDS complement(1269829..1271349) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /EC_number="2.7.13.3" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine kinase phosphorylating Spo0A" /protein_id="NP_389249.1" /db_xref="EnsemblGenomes-Gn:BSU13660" /db_xref="EnsemblGenomes-Tr:CAB13239" /db_xref="GOA:O31671" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4JGO" /db_xref="PDB:4JGP" /db_xref="PDB:4JGQ" /db_xref="PDB:4JGR" /db_xref="SubtiList:BG13309" /db_xref="UniProtKB/Swiss-Prot:O31671" /translation="MLERCKLKILKGACGRVKLYIILVVIPAIVISFFVYEKEKDTIA AEHKQEASVLLNLHRNKINYLIGETMARMTSLSIAIDRPVDIKKMQSILEKTFDSEPR FSGLYFLNAKGDVTASTTELKTKVNLADRSFFIKAKETKKTVISDSYSSRITGQPIFT ICVPVLDSKRNVTDYLVAAIQIDYLKNLINLLSPDVYIEVVNQDGKMIFASGQASHAE DQKPVSGYLDDISWNMKVYPNPVTIEELSKSLVLPLSCIIVLLNILFILVLYYLLKRQ TQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIE QEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTE QPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQE MLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS*" /label="kinD CDS" gene complement(1269829..1271349) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /label="kinD gene" downshifts complement(1269841) /Source="Nicolas_upshifts" /id="D753" /incds=0 /nref=106 /ntot=227 /MaxReadThrough="0.62895" /MaxDrop="5.24795" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1109" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1270550..1270556 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1270570..1270581 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1270576 /Source="Nicolas_upshifts" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1271357..1271376) /Source="Nicolas_upshift_promotors" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1271378) /Source="Nicolas_upshifts" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1271476..1271483 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1271498..1271517 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1271500 /Source="Nicolas_upshifts" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="upshifts" CDS 1271542..1271979 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17725564, 17962296, 18282125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17725564, 17962296, 18282125; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family)" /protein_id="NP_389250.1" /db_xref="EnsemblGenomes-Gn:BSU13670" /db_xref="EnsemblGenomes-Tr:CAB13240" /db_xref="GOA:O31672" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13310" /db_xref="UniProtKB/Swiss-Prot:O31672" /translation="MTEKSLKLFIVLSRAYRSINDHMNKHIHKHGLNPTEFAVLELLY HKGDQPLQQIGDKILLASGSITYVVDKLEQKELLIRKASPTDRRVTFAQITEKGIGLL NDIFPDHAAEIDEMISVLSEEEVEMCTEMLKRVGLNAKQFHNK*" /label="mhqR CDS" gene 1271542..1271979 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /label="mhqR gene" downshifts 1271962 /Source="Nicolas_upshifts" /id="D754" /incds=0 /nref=210 /ntot=257 /MaxReadThrough="1.20686" /MaxDrop="5.47215" /score="1.59181784" /energy="-8.9" /TU="U1110" /idTUdmin="U1110" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1272019..1272804) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein B; MotB component of the H+-coupled stator flagellum complex" /protein_id="NP_389251.1" /db_xref="EnsemblGenomes-Gn:BSU13680" /db_xref="EnsemblGenomes-Tr:CAB13241" /db_xref="GOA:P28612" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10689" /db_xref="UniProtKB/Swiss-Prot:P28612" /translation="MARKKKKKHEDEHVDESWLVPYADILTLLLALFIVLYASSSIDA AKFQMLSKSFNEVFTGGTGVLDYSSVTPPENESDGIDEVKKEKEEKEKNKKEKEKAAD QEELENVKSQVEKFIKDKKLEHQLETKMTSEGLLITIKDSIFFDSGKATIRKEDVPLA KEISNLLVINPPRNIIISGHTDNMPIKNSEFQSNWHLSVMRAVNFMGLLIENPKLDAK VFSAKGYGEYKPVASNKTAEGRSKNRRVEVLILPRGAAETNEK*" /label="motB CDS" gene complement(1272019..1272804) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /label="motB gene" downshifts complement(1272038) /Source="Nicolas_upshifts" /id="D755" /incds=0 /nref=224 /ntot=246 /MaxReadThrough="3.05351" /MaxDrop="6.69306" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(1272500) /Source="Nicolas_upshifts" /id="D756" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="8.03566" /MaxDrop="4.69358" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1272776..1273588) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein A; MotA component of the H+-coupled stator flagellum complex" /protein_id="NP_389252.1" /db_xref="EnsemblGenomes-Gn:BSU13690" /db_xref="EnsemblGenomes-Tr:CAB13242" /db_xref="GOA:P28611" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10688" /db_xref="UniProtKB/Swiss-Prot:P28611" /translation="MDKTSLIGIILAFVALSVGMVLKGVSFSALANPAAILIIIAGTI SAVVIAFPTKEIKKVPTLFRVLFKENKQLTIEELIPMFSEWAQLARREGLLALEASIE DVDDAFLKNGLSMAVDGQSAEFIRDIMTEEVEAMEDRHQAGAAIFTQAGTYAPTLGVL GAVIGLIAALSHMDNTDELGHAISAAFVATLLGIFTGYVLWHPFANKLKRKSKQEVKL REVMIEGVLSVLEGQAPKVIEQKLLMYLPAKDRLKFAEQGEAQNGEKKEEEA*" /label="motA CDS" gene complement(1272776..1273588) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /label="motA gene" promotor_-10 complement(1273619..1273637) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1273635) /Source="Nicolas_upshifts" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1273651..1273658) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1273726..1273948) /Source="Nicolas_S_feature" /locus_tag="new_1435383_1435605_c" /HighExp="Diami, dia15, dia5, Heat, Etha, LPhT, H2O2, C30, G135, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.93062599999999995" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S491" downshifts complement(1273758) /Source="Nicolas_upshifts" /id="D757" /incds=0 /nref=5 /ntot=12 /MaxReadThrough="0.48394" /MaxDrop="4.60081" /score="30.9355071" /energy="-15.4" /TU="NA" /idTUdmin="U1112" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1273971..1276070) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease (class III stress gene)" /protein_id="NP_389253.1" /db_xref="EnsemblGenomes-Gn:BSU13700" /db_xref="EnsemblGenomes-Tr:CAB13243" /db_xref="GOA:O31673" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="SubtiList:BG12578" /db_xref="UniProtKB/Swiss-Prot:O31673" /translation="MRCQHCHQNEATIRLNMQINSVHKQMVLCETCYNELTRKPSMSM GPQSFGFPFEQAFQPKEQSAAKQSEKKGLLDELAQNITNGAKAGLIDPVIGRDDEVAR VIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVA NTGIRGQFEERMKQLITELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARG ELQVIGATTLKEYRQIEKDAALERRFQPVMVQEPSIEQAILILQGIKDKYEAYHGVTF SDEAIKACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLLIDELNDEDAAERLTAIEAE KTKALEEENYELAAKLRDEELALEKKLNSSSAHTAVTVEAEHIQEIVEQKTGIPVGKL QADEQTKMKELEAKLHERVIGQEAAVQKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGV GKTELSKTLADELFGTKDAIIRLDMSEYMEKHAVSKIIGSPPGYVGHEEAGQLTEKVR RNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVIIMTSNAGAGEK QTKVGFQSDDSVIEEQTLIDSLSMFFKPEFLNRFDSIIEFRSLEKEHLVKIVSLLLGE LEETLAERGISLNVTDEAKEKIAELGYHPSFGARPLRRTIQEWVEDEMTDLLLDNGEI TSFHVILEDDKIKVRAK*" /label="clpE CDS" gene complement(1273971..1276070) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /label="clpE gene" downshifts complement(1273993) /Source="Nicolas_upshifts" /id="D758" /incds=0 /nref=27 /ntot=132 /MaxReadThrough="4.1802" /MaxDrop="6.07862" /score="41.2563375" /energy="-13.6" /TU="U1112" /idTUdmin="U1112" /TUdmin="-239" /isTUend="FALSE" /label="downshifts" S_feature complement(1276071..1276321) /Source="Nicolas_S_feature" /locus_tag="new_1437728_1437978_c" /HighExp="dia5, Heat, Diami, LPhT, dia15, H2O2, HiTm, S2, Cold, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S492" promotor_no_box complement(1276281..1276381) /Source="Nicolas_upshift_promotors" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1276321) /Source="Nicolas_upshifts" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1276357..1276362 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1276372 /Source="Nicolas_upshifts" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1276378..1276396 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1276435..1277478 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389254.1" /db_xref="EnsemblGenomes-Gn:BSU13710" /db_xref="EnsemblGenomes-Tr:CAB13244" /db_xref="GOA:O31674" /db_xref="SubtiList:BG13311" /db_xref="UniProtKB/Swiss-Prot:O31674" /translation="MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFG ILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVM LSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVA DSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGA LIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSV IGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIG ALLCKKAPRRRSL*" /label="ykvI CDS" gene 1276435..1277478 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /label="ykvI gene" S_feature 1277479..1277570 /Source="Nicolas_S_feature" /locus_tag="new_1439136_1439227" /HighExp="S3, LoTm, S4, S5, BT, M9-stat, S6, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S493" promotor_-35 1277547..1277551 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1277568..1277587 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1277572 /Source="Nicolas_upshifts" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1277617..1277661 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /product="preQ1 riboswitch" /experiment="publication(s) with functional evidences, PMID:17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311; Product type n: RNA" /function="16.3: Control" /label="qswA RNA" gene 1277617..1277661 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /label="qswA gene" downshifts 1277638 /Source="Nicolas_upshifts" /id="D759" /incds=0 /nref=11 /ntot=17 /MaxReadThrough="7.29177" /MaxDrop="4.09959" /score="21.1398563" /energy="-9.5" /TU="U1114" /idTUdmin="U1113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1277683..1277790 /Source="Nicolas_S_feature" /locus_tag="new_1439340_1439447" /HighExp="Paraq, ferm, G180, LBGstat, Diami, H2O2, LPhT, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S494" CDS 1277791..1278450 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /EC_number="6.3.4.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14660578, 16199558, 17384645, 18491386, 19354300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14660578, 16199558, 17384645, 18491386, 19354300; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pre-queuosine 0 synthase" /protein_id="NP_389255.1" /db_xref="EnsemblGenomes-Gn:BSU13720" /db_xref="EnsemblGenomes-Tr:CAB13245" /db_xref="GOA:O31675" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018317" /db_xref="PDB:3BL5" /db_xref="SubtiList:BG13312" /db_xref="UniProtKB/Swiss-Prot:O31675" /translation="MKKEKAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYNQRHSQE VEVAKSIAEKLGVKNHLLDMSLLNQLAPNALTRNDIEIEVKDGELPSTFVPGRNLVFL SFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFVIHTPLMW LNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKGYEEYMVMKGER A*" /label="queC CDS" gene 1277791..1278450 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /label="queC gene" CDS 1278443..1278892 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /EC_number="4.1.2.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 18259064, 19231875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 18259064, 19231875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine biosynthesis" /protein_id="NP_389256.1" /db_xref="EnsemblGenomes-Gn:BSU13730" /db_xref="EnsemblGenomes-Tr:CAB13246" /db_xref="GOA:O31676" /db_xref="InterPro:IPR007115" /db_xref="SubtiList:BG13313" /db_xref="UniProtKB/Swiss-Prot:O31676" /translation="MHKLLSQIYPQAQHPYSFELNKDMHISAAHFIPRESAGACSRVH GHTYTVNITVAGDELDDSGFLVNFSVLKKLVHGNYDHTLLNDHEDFSQDDRYSLPTTE VVAKTIYDNVQAYLDTLENKPTCVQVFVRETPTSYCVYRPKKGGLNG*" /label="queD CDS" gene 1278443..1278892 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /label="queD gene" CDS 1278885..1279616 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /EC_number="4.3.99.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 19354300, 23194065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 19354300, 23194065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-carboxy-7-deazaguanine synthase" /protein_id="NP_389257.1" /db_xref="EnsemblGenomes-Gn:BSU13740" /db_xref="EnsemblGenomes-Tr:CAB13247" /db_xref="GOA:O31677" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR017742" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR024924" /db_xref="PDB:5TGS" /db_xref="PDB:5TH5" /db_xref="SubtiList:BG13314" /db_xref="UniProtKB/Swiss-Prot:O31677" /translation="MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSA FTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENN IRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSL KVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVA VDAELNLVRVLPQLHTLLWGNKRGV*" /label="queE CDS" gene 1278885..1279616 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /label="queE gene" CDS 1279634..1280131 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /EC_number="1.7.1.13" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent 7-cyano-7-deazaguanine reductase" /protein_id="NP_389258.1" /db_xref="EnsemblGenomes-Gn:BSU13750" /db_xref="EnsemblGenomes-Tr:CAB13248" /db_xref="GOA:O31678" /db_xref="InterPro:IPR016856" /db_xref="InterPro:IPR029500" /db_xref="PDB:4F8B" /db_xref="PDB:4FGC" /db_xref="PDB:5UDG" /db_xref="SubtiList:BG13315" /db_xref="UniProtKB/Swiss-Prot:O31678" /translation="MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYF VKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMN IIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPE TIDNR*" /label="queF CDS" gene 1279634..1280131 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /label="queF gene" S_feature 1280132..1280408 /Source="Nicolas_S_feature" /locus_tag="new_1441789_1442065" /HighExp="Paraq, ferm, LPhT, C30, G135, G180, LBGstat, Oxctl, G150, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S495" downshifts 1280366 /Source="Nicolas_upshifts" /id="D760" /incds=0 /nref=200 /ntot=247 /MaxReadThrough="1.17154" /MaxDrop="6.60953" /score="11.1883045" /energy="-7.8" /TU="NA" /idTUdmin="U1114" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1280376) /Source="Nicolas_upshifts" /id="D761" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.54726" /MaxDrop="2.16508" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature complement(1280445..1280689) /Source="Nicolas_S_feature" /locus_tag="new_1442102_1442346_c" /HighExp="Diami, dia5, LPhT, Etha, Salt, dia15, Heat, HiTm, C30, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15795400000000001" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S496" downshifts complement(1280486) /Source="Nicolas_upshifts" /id="D762" /incds=0 /nref=47 /ntot=193 /MaxReadThrough="2.13712" /MaxDrop="5.08206" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1280690..1281046) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HGT island)" /protein_id="NP_389259.1" /db_xref="EnsemblGenomes-Gn:BSU13760" /db_xref="EnsemblGenomes-Tr:CAB13249" /db_xref="GOA:O31679" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13316" /db_xref="UniProtKB/Swiss-Prot:O31679" /translation="MKKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNI TQKMLIQTLRELEASGLVSRKMYNQVPPKVEYSSTELGESLKPILQELCQWGGYYAEQ EYAEGEYEIVQPEQLS*" /label="ykvN CDS" gene complement(1280690..1281046) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /label="ykvN gene" misc_feature complement(1281077..1281096) /Source="Nicolas_upshift_promotors" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1281094) /Source="Nicolas_upshifts" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1281131..1281149 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1281136 /Source="Nicolas_upshifts" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="upshifts" CDS 1281215..1281961 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018, 26494135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (HGT island)" /protein_id="NP_389260.1" /db_xref="EnsemblGenomes-Gn:BSU13770" /db_xref="EnsemblGenomes-Tr:CAB13250" /db_xref="GOA:O31680" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13317" /db_xref="UniProtKB/Swiss-Prot:O31680" /translation="MGKFEGKIALVTGGTSGIGLATAQKFVNEGAYVYITGRRQNELD KAVNQIGKNVTGVQGDISKLEDLDKLYDIIKQEKGKLDILFANAGIGNFLPLGEITEE QVDRTFDINVKGTIFTVQKALSLFPDKVGSIIVTGSTAGSIGNPAFSVYGASKAALRA LVRNWILDLKGTEIRVNVVSPGGILTPAYDELFGDALEEVLENSRNTVPAGKVGTPEE VANAVSFLASDESSYLTGVELFVDGGLAQV*" /label="ykvO CDS" gene 1281215..1281961 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /label="ykvO gene" downshifts 1282016 /Source="Nicolas_upshifts" /id="D763" /incds=0 /nref=19 /ntot=146 /MaxReadThrough="0.723690000000001" /MaxDrop="4.37163" /score="1.34631843" /energy="-9.1" /TU="NA" /idTUdmin="U1116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1282364..1282372 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1282386..1282405 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1282390 /Source="Nicolas_upshifts" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="upshifts" CDS 1282442..1283641 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11011148, 16683018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16683018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein (HGT island)" /protein_id="NP_389261.1" /db_xref="EnsemblGenomes-Gn:BSU13780" /db_xref="EnsemblGenomes-Tr:CAB13251" /db_xref="GOA:O31681" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13318" /db_xref="UniProtKB/Swiss-Prot:O31681" /translation="MKILFLESHPMWLYGLPNGFREAGHTVMISGPVSRENITEMIDE FKPDLIVSMGWTPEHSREKQAWIRNATKKVNIPLVYWATEDPLHTQNFTIPLIKKMKP DFVFTVTPSLCKTYESMGIKAAHLDFAFHESIHHQIKPLAKYSCDIAVVANAYPNFLE EHPEVFRSSSLKTLIRPLIRKGIRIDFWGRNWEKMSKYIGREIPRNWIHGYLDYTEAY KVYSSAKIIIGLQNCESQLTQRTYEILGSGGFLLTSDTPAVRGKFKPGRDLIVSSSPK ETLEKVKYYLNHDSERKKIQINGKKAVKNDSYRHRAERMLEVLKSRGIIRNLGETIHY VDVLKEKYVIHHVTPGETLSIIASKYNVSLQQLMELNHFKSDQIYAGQIIKIREKLFR NINNKLF*" /label="ykvP CDS" gene 1282442..1283641 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /label="ykvP gene" promotor_-35 1282524..1282530 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1282545..1282563 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1282551 /Source="Nicolas_upshifts" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1283610..1283612 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1283632..1283650 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1283644 /Source="Nicolas_upshifts" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1283657..1283884 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative peptidoglycan binding protein" /protein_id="YP_003097719.1" /db_xref="EnsemblGenomes-Gn:BSU13789" /db_xref="EnsemblGenomes-Tr:CAX52610" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/Swiss-Prot:C0H403" /translation="MKGKIPKIRNQANKVKRTPRYMEFPVTYEVYHVESGDTLWTIAK SFEIPVQQLMNLNKLSSDRIYPGQIIKIRER*" /label="ykzQ CDS" gene 1283657..1283884 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /label="ykzQ gene" misc_feature complement(1283734..1283753) /Source="Nicolas_upshift_promotors" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1283742) /Source="Nicolas_upshifts" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1283885..1283980 /Source="Nicolas_S_feature" /locus_tag="new_1445542_1445637" /HighExp="BT, S8, B36, S7, Etha, S6, G/S, LBGstat, Pyr, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigK" /TUshortPSig="0.602, 0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S497" CDS 1283981..1284679 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /EC_number="3.2.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative sporulation-specific glycosylase (HGT island)" /db_xref="EnsemblGenomes-Gn:BSU13790" /db_xref="EnsemblGenomes-Tr:CAB13252" /db_xref="GOA:O31682" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAB13252.1" /db_xref="SubtiList:BG13319" /db_xref="UniProtKB/Swiss-Prot:O31682" /translation="MFQMSYYYSGLGWDFIQHVDQTNGVLNVVSPDFFYIRKDGSLLL RSANPDVIKALHRRKLKVVPFLSNHWDQDLGRFALMNRVLLAKQISHAIEELDLDGVN IDIENLTEKDRNLFTDFIRLVRKSIPRHKEVSVAVAANPFGWTKGWHGSYDYEYLAKY ADYLMVMAYDESRLAGPTASVGWVEKSIQYVLTQKISPQKLVLGLPFYGRCWMEGQSA SQAIPLYLVVSKKA*" /label="ykvQ CDS" gene 1283981..1284679 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /pseudo /label="ykvQ gene" S_feature complement(1284632..1285458) /Source="Nicolas_S_feature" /locus_tag="new_1446289_1447115_c" /HighExp="H2O2, M40t90, S8, M40t45, LPhT, Sw, Cold, LBGstat, C30, dia15" /AntisenseName="ykzR" /AntisenseCor="0.170402182980955" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="0.38670900000000002" /TUshortSig="SigA" /TUshortPSig="0.986" /TUlongSig="NA" /TUlongPSig="NA" /label="S498" CDS 1284660..1284911 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative spore-specific glycosyl hydrolase" /db_xref="EnsemblGenomes-Gn:BSU13799" /db_xref="EnsemblGenomes-Tr:CAX52611" /db_xref="GOA:C0H404" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAX52611.1" /db_xref="UniProtKB/Swiss-Prot:C0H404" /translation="MLVKRHSGTIIFDTKSQSPKAIFTVNHDKKGPLPSGTYTLWFEN EQSLRAKIKLAQKYNLKGLGSWSLGQEDASVWNTVFKNI*" /label="ykzR CDS" gene 1284660..1284911 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /pseudo /label="ykzR gene" misc_feature 1285161..1285176 /Source="Nicolas_upshift_promotors" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1285184..1285395 /Source="Nicolas_S_feature" /locus_tag="new_1446841_1447052" /HighExp="Diami, S8, dia15, G180, HPh, C30, Paraq, H2O2, Salt, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.516" /TUlongSig="NA" /TUlongPSig="NA" /label="S499" upshifts 1285184 /Source="Nicolas_upshifts" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="upshifts" downshifts 1285360 /Source="Nicolas_upshifts" /id="D764" /incds=0 /nref=2 /ntot=72 /MaxReadThrough="2.59168" /MaxDrop="2.74537" /score="-4.38958816" /energy="-9" /TU="NA" /idTUdmin="U1121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1285447..1285466) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1285469) /Source="Nicolas_upshifts" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1285482..1285489) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1285534..1285541 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1285556..1285575 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1285558 /Source="Nicolas_upshifts" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="upshifts" CDS 1285594..1285884 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="NP_389263.1" /db_xref="EnsemblGenomes-Gn:BSU13800" /db_xref="EnsemblGenomes-Tr:CAB13253" /db_xref="InterPro:IPR021596" /db_xref="InterPro:IPR023105" /db_xref="PDB:2JN9" /db_xref="SubtiList:BG13320" /db_xref="UniProtKB/Swiss-Prot:O31683" /translation="MKTLRLNNVTLEMAAYQEESEPKRKIAFTLNVTSETYHDIAVLL YEKTFNVEVPERDLAFRGEMTNYSTSLTNLYEPGAVSEFYIEITEIDKNADS*" /label="ykvR CDS" gene 1285594..1285884 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /label="ykvR gene" S_feature complement(1285921..1286004) /Source="Nicolas_S_feature" /locus_tag="new_1447578_1447661_c" /HighExp="Etha, dia5, Salt, SMMPr, Lbtran, dia15, Heat, S4, HiOs, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S500" downshifts complement(1285964) /Source="Nicolas_upshifts" /id="D765" /incds=0 /nref=216 /ntot=257 /MaxReadThrough="2.80569" /MaxDrop="6.83857" /score="21.3524751" /energy="-9.9" /TU="U1124" /idTUdmin="U1126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1286005..1286190) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (HGT island)" /protein_id="NP_389264.2" /db_xref="EnsemblGenomes-Gn:BSU13810" /db_xref="EnsemblGenomes-Tr:CAB13254" /db_xref="InterPro:IPR018690" /db_xref="SubtiList:BG13321" /db_xref="UniProtKB/Swiss-Prot:O31684" /translation="MKIAKVGNVIEFKNGLTGVVEKVNENSVIVDVTIMDNYRDLELD SLTVVNHKNYKIIRDSY*" /label="ykvS CDS" gene complement(1286005..1286190) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /label="ykvS gene" promotor_-10 complement(1286223..1286242) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1286234) /Source="Nicolas_upshifts" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1286236..1286580) /Source="Nicolas_S_feature" /locus_tag="new_1447893_1448237_c" /HighExp="S4, S8, S6, S5, S3, T5.0H, LoTm, S7, T4.0H, BT" /AntisenseName="ykzS" /AntisenseCor="-0.65556958045860303" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S501" promotor_-35 complement(1286256..1286263) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1286289..1286294 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1286310..1286329 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1286317 /Source="Nicolas_upshifts" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="upshifts" CDS 1286356..1286550 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="YP_003097721.1" /db_xref="EnsemblGenomes-Gn:BSU13819" /db_xref="EnsemblGenomes-Tr:CAX52612" /db_xref="UniProtKB/Swiss-Prot:C0H405" /translation="MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHF RGIAQQGGDVIFQYLEQPRS*" /label="ykzS CDS" gene 1286356..1286550 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /label="ykzS gene" downshifts 1286526 /Source="Nicolas_upshifts" /id="D766" /incds=0 /nref=6 /ntot=124 /MaxReadThrough="3.66738" /MaxDrop="3.03929" /score="5.82604583" /energy="-10.6" /TU="U1125" /idTUdmin="U1123" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1286571..1286589) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1286587) /Source="Nicolas_upshifts" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1286606..1286611) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1286849..1287475 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12177332, 12950927, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall hydrolase related to spore cortex-lytic enzymes" /protein_id="NP_389265.1" /db_xref="EnsemblGenomes-Gn:BSU13820" /db_xref="EnsemblGenomes-Tr:CAB13255" /db_xref="GOA:O31685" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG13322" /db_xref="UniProtKB/Swiss-Prot:O31685" /translation="MTTKFTALAVFLLCFMPAAKIEHTQASLLSAKKTKHEEAKWLTH IDRNTNESFPSLSADKDKKIKPIKLSAHTEKKEKDKPDKTNDEKETYTQSEKELLSRL VHAEAKGESYKGKVAVASVVLNRTEKKGFPDTIRGVIYQKNAFEPVANGSINQKPDKE SIEAAEEALSSKNRETDAIFFYNPKTASDNWIRSRKIVEKIGRHVFAV*" /label="ykvT CDS" gene 1286849..1287475 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /label="ykvT gene" downshifts 1287406 /Source="Nicolas_upshifts" /id="D767" /incds=1 /nref=1 /ntot=17 /MaxReadThrough="0.932830000000001" /MaxDrop="1.92264" /score="9.80914166" /energy="-11.9" /TU="NA" /idTUdmin="U1125" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1287532..1287537 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1287544 /Source="Nicolas_upshifts" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1287553..1287571 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1287593..1288930 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15686839, 15849754, 16850406, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15686839, 15849754, 16850406, 19648239; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore membrane protein involved in germination" /protein_id="NP_389266.1" /db_xref="EnsemblGenomes-Gn:BSU13830" /db_xref="EnsemblGenomes-Tr:CAB13256" /db_xref="GOA:O31686" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="SubtiList:BG13323" /db_xref="UniProtKB/Swiss-Prot:O31686" /translation="MNRFVKGIILLSIAAFFAECLEFVVNMILARELGEHGMGLYMSI LPTIFLIIVIASLELPISISKFIAESNPKLHESMLRHAFRMTAIFTAFSTAAASIALP FIPVFDTYHPFIKGIVIGLIPVVAFTSIARGYFMGVQKMGKIAIANVLKKIIQLLCLF LFFQWYSFELDMAVLISLFVLVVSDVVVLVYLYSQFIMARRALSGQQHIHLRGKDVRK RLLAVSIPTTGLRIFHAVVNAIEPFLVKGALLAAGVAGTAAIDQYGMLAGVAVTIGSF PAFIAHSLMVVMIPSISEAYALSQYDIVLKRLKQSIFITLGYGIPAVWVMFQFAGPLT HLFFHSPEAQYYLQLLWPYFLFHLFVMPLQACLIGMGFVKEAFYHNVWSHIVALSMMY VLGSMENLQMLGIILGMNTGMILLTSLHYATICKALKVSVFLTGGTRTPRIEG*" /label="ykvU CDS" gene 1287593..1288930 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /label="ykvU gene" CDS 1288981..1289478 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15292147, 15322369, 15342593, 19144642, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292147, 15322369, 15342593, 19144642, 28383125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific thiol-disulfide oxidoreductase (SpoVD maturation)" /protein_id="NP_389267.1" /db_xref="EnsemblGenomes-Gn:BSU13840" /db_xref="EnsemblGenomes-Tr:CAB13257" /db_xref="GOA:O31687" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:3ERW" /db_xref="SubtiList:BG13324" /db_xref="UniProtKB/Swiss-Prot:O31687" /translation="MLTKRLLTIYIMLLGLIAWFPGAAQAEEKQPAVPAVFLMKTIEG EDISIPNKGQKTILHFWTSWCPPCKKELPQFQSFYDAHPSDSVKLVTVNLVNSEQNQQ VVEDFIKANKLTFPIVLDSKGELMKEYHIITIPTSFLLNEKGEIEKTKIGPMTAEQLK EWTEE*" /label="stoA CDS" gene 1288981..1289478 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /label="stoA gene" promotor_-35 1289327..1289333 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1289342 /Source="Nicolas_upshifts" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1289348..1289366 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1289452 /Source="Nicolas_upshifts" /id="D768" /incds=0 /nref=36 /ntot=164 /MaxReadThrough="1.89069" /MaxDrop="4.34947" /score="14.1388498" /energy="-11.3" /TU="NA" /idTUdmin="U1127" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1289573..1289579 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1289590..1289609 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1289602 /Source="Nicolas_upshifts" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1289606..1289713 /Source="Nicolas_S_feature" /locus_tag="new_1451263_1451370" /HighExp="LBGstat, C90, Lbstat, BC, Cold, T0.30H, Etha, Lbtran, LBGtran, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S502" CDS 1289714..1291627 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029044, 12180919, 15802251, 21813502, 26261021, 26566138" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12180919, 15802251, 21813502, 26261021, 26566138; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Fe(II) efflux transporter possibly involved in copper(II) uptake" /protein_id="NP_389268.1" /db_xref="EnsemblGenomes-Gn:BSU13850" /db_xref="EnsemblGenomes-Tr:CAB13258" /db_xref="GOA:O31688" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13325" /db_xref="UniProtKB/Swiss-Prot:O31688" /translation="MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGW LLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWA EGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGD MIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRV TKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGW SWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMI AFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVN QSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFV KKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVV AECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMV LMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGS TILVILNGLRLLK*" /label="pfeT CDS" gene 1289714..1291627 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /label="pfeT gene" promotor_-10 complement(1289863..1289882) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1289880) /Source="Nicolas_upshifts" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1289895..1289904) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1290031..1290050) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1290056) /Source="Nicolas_upshifts" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1290064..1290070) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1291608 /Source="Nicolas_upshifts" /id="D769" /incds=0 /nref=62 /ntot=148 /MaxReadThrough="2.05978" /MaxDrop="6.90668" /score="30.2111295" /energy="-18" /TU="NA" /idTUdmin="U1129" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1291684) /Source="Nicolas_upshifts" /id="D770" /incds=0 /nref=74 /ntot=208 /MaxReadThrough="0.83751" /MaxDrop="4.23141" /score="34.2342147" /energy="-18" /TU="NA" /idTUdmin="U1132" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1291895..1291914) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1291904) /Source="Nicolas_upshifts" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1291928..1291935) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1291979..1291998 /Source="Nicolas_upshift_promotors" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1291989 /Source="Nicolas_upshifts" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="upshifts" CDS 1292034..1293125 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7770058, 23144141" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7770058, 23144141; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Xaa-Pro Xaa-Pro-Xaa di-tri-peptidase used in osmoprotection" /protein_id="NP_389269.1" /db_xref="EnsemblGenomes-Gn:BSU13860" /db_xref="EnsemblGenomes-Tr:CAB13259" /db_xref="GOA:O31689" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG13326" /db_xref="UniProtKB/Swiss-Prot:O31689" /translation="MNRIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGL FIFQEEEPFFVCPGMEAGQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAV EKDSISLSRAEQLKHATGGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVG TAALREGISEVEVLAQIEYELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDF VLFDLGVILDGYCSDITRTFAYKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDL TARGIIEKAGYGDYFPHRLGHGLGISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEI GGVRIEDDVHVTKDGAVALTQYPKDLIIL*" /label="papB CDS" gene 1292034..1293125 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /label="papB gene" downshifts 1292774 /Source="Nicolas_upshifts" /id="D771" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.10599" /MaxDrop="5.06339" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts 1293104 /Source="Nicolas_upshifts" /id="D772" /incds=0 /nref=2 /ntot=52 /MaxReadThrough="5.66039" /MaxDrop="2.56719" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" S_feature complement(1293138..1293356) /Source="Nicolas_S_feature" /locus_tag="new_1454795_1455013_c" /HighExp="B60, B36, C30, G135, LBGstat, S8, Lbstat, C90, Etha, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.92748200000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S503" S_feature 1293149..1293406 /Source="Nicolas_S_feature" /locus_tag="new_1454806_1455063" /HighExp="dia15, dia5, Etha, M0t90, M40t90, Lbstat, H2O2, G150, Mt0, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S504" promotor_-10 complement(1293343..1293362) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1293356) /Source="Nicolas_upshifts" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1293378..1293385) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1293407..1294372 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LacI family)" /protein_id="NP_389270.1" /db_xref="EnsemblGenomes-Gn:BSU13870" /db_xref="EnsemblGenomes-Tr:CAB13260" /db_xref="GOA:O31690" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13327" /db_xref="UniProtKB/Swiss-Prot:O31690" /translation="MANIKDIAEKAGVSVTTVSRVINNHPYVSEDKRKRVFEAMESLE YTRNIHAVHLSKGFSNMIGVVLPTVNLPYFAELIAGIADAAAESGVHLSLFQTNYEVQ KEIFALSQLKQRQVDGLIFCSKALADEKLMEWEGPILLCQNSDNARFPTISIPHQEAF RNGLDYLIAKGHKKIAICLARKKGMNSHFRIKAYKEALEEIGEAFREDWVIEKAITIN DGKALFHKWNTWKEKPTAIFVANDQVSAGLFLEAKNQRVSVPDELAILSVDNHEISQA LGITTIDIQTREMGKQAFAILEKRIQGQPIERKVLDYRLIERSTV*" /label="ykvZ CDS" gene 1293407..1294372 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /label="ykvZ gene" promotor_-35 1294390..1294397 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-35" promotor_-10 1294412..1294431 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-10" upshifts 1294424 /Source="Nicolas_upshifts" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="upshifts" CDS 1294435..1295301 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10974121, 14527945, 15155854, 17074746, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974121, 14527945, 15155854, 17074746, 22750856; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_389271.2" /db_xref="EnsemblGenomes-Gn:BSU13880" /db_xref="EnsemblGenomes-Tr:CAB13261" /db_xref="GOA:O31691" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:3GWH" /db_xref="PDB:3RIO" /db_xref="PDB:3UFE" /db_xref="SubtiList:BG12593" /db_xref="UniProtKB/Swiss-Prot:O31691" /translation="MTKELRIVNGSFTVKKVLNNNVLIASHHKYSEVVLIGKGIGFGK KQDDVIEDKGYDKMFILKDEKEQKQFKKLLDYVDEKLVDISNDVIYHISNRTNHSLNE HIHIALTDHIAFAIKRQQQGFDMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGLCLP EGEIGFIALHIHSALTNRPLSEVNQHSQLMAQLVEVIEDSFQMKVNKESVNYLRLIRH IRFTIERIKKEEPTKEPEKLMLLLKNEYPLCYNTAWKLIKILQQTLKKPVHEAEAVYL TLHLYRLTNKIS*" /label="glcT CDS" gene 1294435..1295301 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /label="glcT gene" promotor_-35 1295156..1295160 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1295177..1295196 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1295185 /Source="Nicolas_upshifts" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" downshifts 1295303 /Source="Nicolas_upshifts" /id="D773" /incds=0 /nref=1 /ntot=30 /MaxReadThrough="9.01653" /MaxDrop="3.09921" /score="-5.18621526" /energy="-6.2" /TU="U1133,U1135,U1136" /idTUdmin="U1135" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_RNA 1295348..1295499 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /product="riboswitch regulating ptsGHI expression via GlcTbinding" /experiment="publication(s) with functional evidences, PMID:15155854, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15155854, 22750856; Product type n: RNA" /label="gswA RNA" S_feature 1295348..1295499 /Source="Nicolas_S_feature" /locus_tag="new_1457005_1457156" /HighExp="LBGexp, G150, C30, G135, G180, MG 90, dia0, Lbexp, dia15, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.988, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S505" gene 1295348..1295499 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /label="gswA gene" promotor_-35 1295477..1295483 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1295497..1295508 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1295501 /Source="Nicolas_upshifts" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="upshifts" CDS 1295530..1297629 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /EC_number="2.7.1.199" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucose-specificenzyme IICBA component" /protein_id="NP_389272.1" /db_xref="EnsemblGenomes-Gn:BSU13890" /db_xref="EnsemblGenomes-Tr:CAB13262" /db_xref="GOA:P20166" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="PDB:1AX3" /db_xref="PDB:1GPR" /db_xref="SubtiList:BG10198" /db_xref="UniProtKB/Swiss-Prot:P20166" /translation="MFKALFGVLQKIGRALMLPVAILPAAGILLAIGNAMQNKDMIQV LHFLSNDNVQLVAGVMESAGQIVFDNLPLLFAVGVAIGLANGDGVAGIAAIIGYLVMN VSMSAVLLANGTIPSDSVERAKFFTENHPAYVNMLGIPTLATGVFGGIIVGVLAALLF NRFYTIELPQYLGFFAGKRFVPIVTSISALILGLIMLVIWPPIQHGLNAFSTGLVEAN PTLAAFIFGVIERSLIPFGLHHIFYSPFWYEFFSYKSAAGEIIRGDQRIFMAQIKDGV QLTAGTFMTGKYPFMMFGLPAAALAIYHEAKPQNKKLVAGIMGSAALTSFLTGITEPL EFSFLFVAPVLFAIHCLFAGLSFMVMQLLNVKIGMTFSGGLIDYFLFGILPNRTAWWL VIPVGLGLAVIYYFGFRFAIRKFNLKTPGREDAAEETAAPGKTGEAGDLPYEILQAMG DQENIKHLDACITRLRVTVNDQKKVDKDRLKQLGASGVLEVGNNIQAIFGPRSDGLKT QMQDIIAGRKPRPEPKTSAQEEVGQQVEEVIAEPLQNEIGEEVFVSPITGEIHPITDV PDQVFSGKMMGDGFAILPSEGIVVSPVRGKILNVFPTKHAIGLQSDGGREILIHFGID TVSLKGEGFTSFVSEGDRVEPGQKLLEVDLDAVKPNVPSLMTPIVFTNLAEGETVSIK ASGSVNREQEDIVKIEK*" /label="ptsG CDS" gene 1295530..1297629 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /label="ptsG gene" promotor_-35 1297647..1297651 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1297667..1297686 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1297678 /Source="Nicolas_upshifts" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1297727..1297993 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein)" /protein_id="NP_389273.1" /db_xref="EnsemblGenomes-Gn:BSU13900" /db_xref="EnsemblGenomes-Tr:CAB13263" /db_xref="GOA:P08877" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1JEM" /db_xref="PDB:1KKL" /db_xref="PDB:1KKM" /db_xref="PDB:1SPH" /db_xref="PDB:2FEP" /db_xref="PDB:2HID" /db_xref="PDB:2HPR" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10200" /db_xref="UniProtKB/Swiss-Prot:P08877" /translation="MAQKTFKVTADSGIHARPATVLVQTASKYDADVNLEYNGKTVNL KSIMGVMSLGIAKGAEITISASGADENDALNALEETMKSEGLGE*" /label="ptsH CDS" gene 1297727..1297993 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /label="ptsH gene" CDS 1297993..1299705 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /EC_number="2.7.3.9" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106335, 11902727, 15155854, 15670601, 25355936, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106335, 11902727, 15155854, 15670601, 25355936, 26159071; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) enzyme I" /protein_id="NP_389274.2" /db_xref="EnsemblGenomes-Gn:BSU13910" /db_xref="EnsemblGenomes-Tr:CAB13264" /db_xref="GOA:P08838" /db_xref="InterPro:IPR000121" /db_xref="InterPro:IPR006318" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR008731" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018274" /db_xref="InterPro:IPR023151" /db_xref="InterPro:IPR024692" /db_xref="InterPro:IPR036618" /db_xref="SubtiList:BG10201" /db_xref="UniProtKB/Swiss-Prot:P08838" /translation="MQELKGIGASAGIAIAKAYRLEEPDLTVEKKNISDSEAEVSRFD EAIARSKEELEKIKEHALKELGQDKADIFSAHLLVLSDPELLNPVKEKISTDSVNAEF ALKETSSMFVTMFESMDNEYMKERAADIRDVTKRVTGHLLGVEIPNPSMISEEVIIVA EDLTPSDTAQLNREFVKGFTTDIGGRTSHSAIMARSLEIPAVVGTKAATGTIQNGVTV IVDGINGDVIIDPSAETVKEYEEKHNAYLAQKAEWAKLVNEPTVSKDGHHVELAANIG TPDDVKGVLENGGEAVGLYRTEFLYMGRDQLPTEDEQFDAYKTVLERMEGKSVVVRTL DIGGDKELPYLQLPKEMNPFLGYRAIRLCLEEQEIFRTQLRALLRASTYGNLKIMFPM IATVNEFKEAKAILLEEKEKLVKAGQAVSDDIEVGMMVEIPSTAVIADQFAKEVDFFS IGTNDLIQYTMAADRMNERVSYLYQPYNPAILRLITLVIEAAHKEGKWVGMCGEMAGD EIAIPILLGLGLDEFSMSATSILPARTQISKLSKQEAESFKEKILSMSTTEEVVAFVK ETFK*" /label="ptsI CDS" gene 1297993..1299705 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /label="ptsI gene" downshifts 1299692 /Source="Nicolas_upshifts" /id="D774" /incds=0 /nref=116 /ntot=277 /MaxReadThrough="5.0255" /MaxDrop="5.64321" /score="21.2608168" /energy="-12.3" /TU="U1136,U1138" /idTUdmin="U1133" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-35 1299745..1299751 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1299766..1299777 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1299769 /Source="Nicolas_upshifts" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1299796..1300035 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9009064, 9323362, 10629212" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9009064, 9323362, 10629212; Product type r: regulator" /codon_start=1 /transl_table=11 /product="TRAP-like transcriptional negative regulator of spore photoproduct lyase" /protein_id="NP_389275.1" /db_xref="EnsemblGenomes-Gn:BSU13920" /db_xref="EnsemblGenomes-Tr:CAB13265" /db_xref="GOA:P37955" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG10202" /db_xref="UniProtKB/Swiss-Prot:P37955" /translation="MSNQFNAGDTVYVIYRNPHAANVAHIKEAEIVHHPYHEGELSLF IYETYHPFAEDDAVFASYEEAKSLYKELFDIDPYE*" /label="splA CDS" gene 1299796..1300035 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /label="splA gene" S_feature complement(1299816..1301155) /Source="Nicolas_S_feature" /locus_tag="new_1461473_1462812_c" /HighExp="T4.0H, T3.30H, T3.0H, S3, S1, T2.0H, T2.30H, S2, T5.0H, S4" /AntisenseName="splB" /AntisenseCor="-0.193138593783996" /AntisenseRegPval="-2.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S506" CDS 1300113..1301141 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /EC_number="4.1.99.14" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore photoproduct (thymine dimer) lyase" /protein_id="NP_389276.1" /db_xref="EnsemblGenomes-Gn:BSU13930" /db_xref="EnsemblGenomes-Tr:CAB13266" /db_xref="GOA:P37956" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023897" /db_xref="InterPro:IPR034560" /db_xref="SubtiList:BG10203" /db_xref="UniProtKB/Swiss-Prot:P37956" /translation="MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQ VRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQT TMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIE HFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIE AAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFT KPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFP NAKIEYFT*" /label="splB CDS" gene 1300113..1301141 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /label="splB gene" downshifts 1301111 /Source="Nicolas_upshifts" /id="D775" /incds=0 /nref=5 /ntot=113 /MaxReadThrough="0.352" /MaxDrop="3.95383" /score="15.9223136" /energy="-13.2" /TU="NA" /idTUdmin="U1136" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1301156..1301836) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase / amidohydrolase" /protein_id="NP_389277.2" /db_xref="EnsemblGenomes-Gn:BSU13940" /db_xref="EnsemblGenomes-Tr:CAB13267" /db_xref="GOA:Q796K9" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12252" /db_xref="UniProtKB/Swiss-Prot:Q796K9" /translation="MIILKQMYVHDGRKFEALTIRNYTETDIERLISLQEECFPPPFP QELLWSEDQLASHIKTFPEGALCALINGRIIGSMTALIVQFEPDSPDHTWAQATDNGS IKNHEPHGNTLYVVDISVSPHYRKLGIGKWLMNTMYELTVDKRLERLLGGGRIPLYYK YAHEISAVQYVEDVMEGRKNDPVLSFLLRCGRSPIRVVSNYLEDKESLNYGVLMEWKN VFYKKASC*" /label="ykwB CDS" gene complement(1301156..1301836) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /label="ykwB gene" promotor_-10 complement(1301846..1301865) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1301869) /Source="Nicolas_upshifts" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1301880..1301887) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1301921..1301928 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-35" promotor_-10 1301942..1301960 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-10" upshifts 1301948 /Source="Nicolas_upshifts" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="upshifts" CDS 1301971..1303938 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9721285, 11722727, 12603740, 15317802, 23038252, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9721285, 11722727, 12603740, 15317802, 23038252, 27899502; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_389278.2" /db_xref="EnsemblGenomes-Gn:BSU13950" /db_xref="EnsemblGenomes-Tr:CAB13268" /db_xref="GOA:P54576" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG11533" /db_xref="UniProtKB/Swiss-Prot:P54576" /translation="MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTT QNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDD YVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDM IVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQ GKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNR ANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGIL TRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGAS EQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEA NMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAV VADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVL NTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDE QLVTLDKVKHSTETLKHASQELMNTIAKFTL*" /label="mcpC CDS" gene 1301971..1303938 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /label="mcpC gene" misc_feature complement(1302411..1302426) /Source="Nicolas_upshift_promotors" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1302423) /Source="Nicolas_upshifts" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1303909 /Source="Nicolas_upshifts" /id="D776" /incds=0 /nref=134 /ntot=209 /MaxReadThrough="3.05506" /MaxDrop="5.75836" /score="24.6367658" /energy="-12.1" /TU="U1141" /idTUdmin="U1141" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1303982..1303984 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1304000..1304019 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1304010 /Source="Nicolas_upshifts" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1304052) /Source="Nicolas_upshifts" /id="D777" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="2.29647" /MaxDrop="4.49503" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=946 /isTUend="FALSE" /label="downshifts" CDS 1304076..1304942 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /EC_number="1.1.1.60" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20941576, 24390483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20941576, 24390483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)" /protein_id="NP_389279.1" /db_xref="EnsemblGenomes-Gn:BSU13960" /db_xref="EnsemblGenomes-Tr:CAB13269" /db_xref="GOA:O34948" /db_xref="InterPro:IPR002204" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13328" /db_xref="UniProtKB/Swiss-Prot:O34948" /translation="MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQK GAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSL AKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQ YQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLS NLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEEN SGTQSIYKLWVK*" /label="ohaC CDS" gene 1304076..1304942 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /label="ohaC gene" downshifts 1304922 /Source="Nicolas_upshifts" /id="D778" /incds=0 /nref=239 /ntot=266 /MaxReadThrough="2.14032" /MaxDrop="8.18847" /score="41.1703019" /energy="-14.5" /TU="NA" /idTUdmin="U1143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1304981..1305754) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389280.2" /db_xref="EnsemblGenomes-Gn:BSU13970" /db_xref="EnsemblGenomes-Tr:CAB13270" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR014258" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13329" /db_xref="UniProtKB/Swiss-Prot:O31398" /translation="MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQ NMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKT TEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDE TLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVV KAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK*" /label="ykwD CDS" gene complement(1304981..1305754) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /label="ykwD gene" downshifts complement(1304998) /Source="Nicolas_upshifts" /id="D779" /incds=0 /nref=31 /ntot=168 /MaxReadThrough="1.32532" /MaxDrop="5.28625" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1305786..1305805) /Source="Nicolas_upshift_promotors" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1305796) /Source="Nicolas_upshifts" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1306029..1306048 /Source="Nicolas_upshift_promotors" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1306042 /Source="Nicolas_upshifts" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1306044..1306147 /Source="Nicolas_S_feature" /locus_tag="new_1467701_1467804" /HighExp="T4.0H, T3.30H, T3.0H, Etha, T5.0H, T2.30H, LoTm, B60, T2.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S507" CDS 1306091..1308205 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12896990, 23199363" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12896990, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall" /protein_id="NP_389281.2" /db_xref="EnsemblGenomes-Gn:BSU13980" /db_xref="EnsemblGenomes-Tr:CAB13271" /db_xref="GOA:Q796K8" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13286" /db_xref="UniProtKB/Swiss-Prot:Q796K8" /translation="MTEIGREPKKKSKGNRAIRMNLFFLAVFVLFTALIFKLGVVQIV EGEQHEEDAEKSNAKTAYYPAPRGKMYDRNQKVAVDNQSVPEIVYVSTSSTKTEDKIK TAKRLASFIHIDTEFLKERDLRDYWIAAHPKKAAALLKESESNLKGDQAYKLQIERVP DQELKAIQQDDEEMETAAIYTRFSSGNAYEPQIVKAMNPNKSNSNGKNGALLDEKKNS SQRPKNDLTYDEISIVSEHLEELPGIDIVNDWTRKYPYDKTLYSVFGGVTTPDQGLLS DRKDFYLTRGYANNDRVGKSYLEYQYEEYLNSHKEKVEYVEDNKGNVVSQKTIDKGSR GYDLQLSFDMELQAKVEKIIEEEVRNSRARGNYMLDRAFAVMMDPNNGDILSMAGKKI DLKTNKIEDYAIGAFTTQYEMGSAVKGATVLAGYQDGIPHYKYYIDAPMLLGTNLIKK SYTNMGTINELTALQKSSNVYMFNVAMHIAGVTYKPHGSLPADQNDLLKMRNYYSQFG LGVKTGIDLPQESAGMQTTPKTVGGLILDLAIGQYDTYTPLQMAQYISVIANGGYRVQ PRIVTSIHKPGKKDQLGKAIEHRKPKVLNKINNSESDLKQVQTGMKLVTSSGTAKNTF TEDVSGKTGTAETFYYGTNRNWWGKKTYNLTFVGYYPSKKPKVAFSVVVPSVDDDDKI NKIIAKRAIHAYAELEKKHSKK*" /label="pbpH CDS" gene 1306091..1308205 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /label="pbpH gene" promotor_-10 complement(1307384..1307402) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1307396) /Source="Nicolas_upshifts" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1307418..1307423) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1308186 /Source="Nicolas_upshifts" /id="D780" /incds=0 /nref=139 /ntot=246 /MaxReadThrough="3.36066" /MaxDrop="5.01597" /score="-1.2500858" /energy="-12" /TU="U1145" /idTUdmin="U1145" /TUdmin="-1862" /isTUend="FALSE" /label="downshifts" promotor_-35 1308278..1308286 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1308298..1308316 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1308310 /Source="Nicolas_upshifts" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="upshifts" CDS 1308369..1310189 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific ATP-dependent protein histidine kinase" /protein_id="NP_389282.1" /db_xref="EnsemblGenomes-Gn:BSU13990" /db_xref="EnsemblGenomes-Tr:CAB13272" /db_xref="GOA:P16497" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013655" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:2VLG" /db_xref="SubtiList:BG10204" /db_xref="UniProtKB/Swiss-Prot:P16497" /translation="MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGE MIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAER TEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISV KGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ TWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNS IDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQ KTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEK LSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELL MLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQ VFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK*" /label="kinA CDS" gene 1308369..1310189 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /label="kinA gene" CDS complement(1310200..1311381) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /EC_number="2.6.1.83" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 14523133, 14627808, 19948795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 14523133, 14627808, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-L,L-diaminopimelate aminotransferase" /protein_id="NP_389283.2" /db_xref="EnsemblGenomes-Gn:BSU14000" /db_xref="EnsemblGenomes-Tr:CAB13273" /db_xref="GOA:P16524" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10205" /db_xref="UniProtKB/Swiss-Prot:P16524" /translation="MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPH HVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAI DAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTP NTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATY LRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAV TNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMA LLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNG V*" /label="dapX CDS" gene complement(1310200..1311381) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /label="dapX gene" downshifts complement(1310234) /Source="Nicolas_upshifts" /id="D781" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="1.89632" /MaxDrop="6.70715" /score="-6.17975559" /energy="-4.7" /TU="NA" /idTUdmin="U1148" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1311409..1311428) /Source="Nicolas_upshift_promotors" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1311425) /Source="Nicolas_upshifts" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1311457..1311475) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1311469) /Source="Nicolas_upshifts" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1311471..1311539) /Source="Nicolas_S_feature" /locus_tag="new_1473128_1473196_c" /HighExp="M9-stat, Lbtran, Lbstat, T3.30H, T3.0H, T2.30H, M0t90, T4.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S508" promotor_-35 complement(1311490..1311495) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1311533..1311552) /Source="Nicolas_upshift_promotors" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1311539) /Source="Nicolas_upshifts" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1311583..1311744) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097722.1" /db_xref="EnsemblGenomes-Gn:BSU14009" /db_xref="EnsemblGenomes-Tr:CAX52613" /db_xref="UniProtKB/Swiss-Prot:C0H406" /translation="MGTLVIFKENEMTVLEDISEETYLNMKKESADLQEEHPPYLIWH EDLHFDYGY*" /label="ykzT CDS" gene complement(1311583..1311744) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /label="ykzT gene" promotor_-10 complement(1311767..1311786) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1311780) /Source="Nicolas_upshifts" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1311800..1311807) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1311881..1311888 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1311900 /Source="Nicolas_upshifts" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1311901..1311919 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1311948..1312859 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11553614, 12864845, 14731274, 14993307, 26844549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11553614, 12864845, 14731274, 14993307, 26844549; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling protein and response regulator for CheAactivity in response to attractants (chemotaxis)" /protein_id="NP_389284.1" /db_xref="EnsemblGenomes-Gn:BSU14010" /db_xref="EnsemblGenomes-Tr:CAB13274" /db_xref="GOA:P37599" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024181" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10823" /db_xref="UniProtKB/Swiss-Prot:P37599" /translation="MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVE VTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVG SVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDT YNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNL AENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRG EVVGADEQISKPEISDLIKKVDTYVIE*" /label="cheV CDS" gene 1311948..1312859 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /label="cheV gene" downshifts complement(1311953) /Source="Nicolas_upshifts" /id="D782" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="1.14523" /MaxDrop="3.62759" /score="-8.29055697" /energy="-7.7" /TU="NA" /idTUdmin="U1154" /TUdmin=968 /isTUend="FALSE" /label="downshifts" promotor_-35 1312402..1312410 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1312424..1312441 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1312427 /Source="Nicolas_upshifts" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1312844 /Source="Nicolas_upshifts" /id="D783" /incds=0 /nref=188 /ntot=251 /MaxReadThrough="4.61331" /MaxDrop="6.23797" /score="15.4598573" /energy="-13.1" /TU="U1152" /idTUdmin="U1153" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1312903..1313367) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of transcription factor ComK function via modulation of mRNA stability" /protein_id="NP_389285.1" /db_xref="EnsemblGenomes-Gn:BSU14020" /db_xref="EnsemblGenomes-Tr:CAB13275" /db_xref="InterPro:IPR025552" /db_xref="SubtiList:BG11202" /db_xref="UniProtKB/Swiss-Prot:P42430" /translation="MDDHAYTKDLQPTVENLSKAVYTVNRHAKTAPNPKYLYLLKKRA LQKLVKEGKGKKIGLHFSKNPRFSQQQSDVLISIGDYYFHMPPTKEDFEHLPHLGTLN QSYRNPKAQMSLTKAKHLLQEYVGMKEKPLVPNRQQPAYHKPVFKKLGESYF*" /label="kre CDS" gene complement(1312903..1313367) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /label="kre gene" downshifts complement(1312921) /Source="Nicolas_upshifts" /id="D784" /incds=0 /nref=212 /ntot=260 /MaxReadThrough="2.67186" /MaxDrop="6.66359" /score="16.1985615" /energy="-13.1" /TU="NA" /idTUdmin="U1154" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1313397..1313416) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1313407) /Source="Nicolas_upshifts" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1313431..1313438) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1313493..1314785) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389286.2" /db_xref="EnsemblGenomes-Gn:BSU14030" /db_xref="EnsemblGenomes-Tr:CAB13276" /db_xref="GOA:O31695" /db_xref="InterPro:IPR004751" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13287" /db_xref="UniProtKB/Swiss-Prot:O31695" /translation="MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSY TTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLV FCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYN TIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILY ILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLA GSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIA IGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVII LLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV*" /label="ykuC CDS" gene complement(1313493..1314785) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /label="ykuC gene" downshifts complement(1313515) /Source="Nicolas_upshifts" /id="D785" /incds=0 /nref=37 /ntot=206 /MaxReadThrough="4.24449" /MaxDrop="4.31411" /score="3.5676583" /energy="-14.2" /TU="U1155" /idTUdmin="U1156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1314809..1314828) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-10" upshifts complement(1314813) /Source="Nicolas_upshifts" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="upshifts" promotor_-35 complement(1314844..1314848) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-35" CDS complement(1314861..1315355) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11011148, 16287140, 23832002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16287140, 23832002; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="murein L,D-transpeptidase" /protein_id="NP_389287.1" /db_xref="EnsemblGenomes-Gn:BSU14040" /db_xref="EnsemblGenomes-Tr:CAB13277" /db_xref="GOA:O34816" /db_xref="InterPro:IPR005490" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:1Y7M" /db_xref="PDB:2MTZ" /db_xref="PDB:3ZQD" /db_xref="PDB:4A1I" /db_xref="PDB:4A1J" /db_xref="PDB:4A1K" /db_xref="PDB:4A52" /db_xref="SubtiList:BG13288" /db_xref="UniProtKB/Swiss-Prot:O34816" /translation="MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIV IPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQR NPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRV TINR*" /label="ltdD CDS" gene complement(1314861..1315355) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /label="ltdD gene" promotor_-10 complement(1315371..1315390) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1315387) /Source="Nicolas_upshifts" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1315404..1315413) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1315412..1316272) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22767609, 24140208" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22767609, 24140208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported metallophosphoesterase (Mn2+ and Zn2+)" /protein_id="NP_389288.2" /db_xref="EnsemblGenomes-Gn:BSU14050" /db_xref="EnsemblGenomes-Tr:CAB13278" /db_xref="GOA:O34870" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR019546" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13289" /db_xref="UniProtKB/Swiss-Prot:O34870" /translation="MKKMSRRQFLKGMFGALAAGALTAGGGYGYARYLEPHMIETTEH TIKSSLIPHGFDGFKIVQFSDAHLSDYFTLEDLKTVILTINESKPDLIVFTGDIIDNP DTYQHHQAVIPLLRKLNAPFGKLCIYGNHDHGGYGTAVYKSLMTAGGFTVYRNGYQTL SLADGSKIEIASLDDLMLGNPDYEGTLSRLSDRLFSILLVHEPDAALKTTDYPVNLQL SGHTHGGQIQLPFYGPIITPPYGKVYTEGMYQTGSTHIYVNRGLGMTRLPLRFLAKPE ITVFTLKSTN*" /label="ppeE CDS" gene complement(1315412..1316272) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /label="ppeE gene" misc_feature complement(1316293..1316312) /Source="Nicolas_upshift_promotors" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1316306) /Source="Nicolas_upshifts" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="upshifts" promotor_-35 1316343..1316350 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-35" promotor_-10 1316366..1316385 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-10" upshifts 1316379 /Source="Nicolas_upshifts" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="upshifts" CDS 1316415..1317179 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /EC_number="1.3.1.34" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2,4-dienoyl-CoA reductase" /protein_id="NP_389289.1" /db_xref="EnsemblGenomes-Gn:BSU14060" /db_xref="EnsemblGenomes-Tr:CAB13279" /db_xref="GOA:O34717" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13290" /db_xref="UniProtKB/Swiss-Prot:O34717" /translation="MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETK KEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPN GWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGV LSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTP EEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF*" /label="fadH CDS" gene 1316415..1317179 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /label="fadH gene" S_feature 1317180..1317328 /Source="Nicolas_S_feature" /locus_tag="new_1478837_1478985" /HighExp="T0.30H, T1.0H, B60, Sw, BC, LoTm, M9-stat, S8, S7, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S509" misc_feature 1317309..1317327 /Source="Nicolas_upshift_promotors" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1317330..1317479 /Source="Nicolas_S_feature" /locus_tag="new_1478987_1479136" /HighExp="T0.30H, M40t90, T1.0H, B60, BC, Sw, LPh, LoTm, M9-stat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0, 0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S510" upshifts 1317330 /Source="Nicolas_upshifts" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1317377) /Source="Nicolas_upshifts" /id="D786" /incds=0 /nref=3 /ntot=49 /MaxReadThrough="1.82681" /MaxDrop="3.39884" /score="-0.170855674" /energy="-4.8" /TU="NA" /idTUdmin="U1157" /TUdmin="-2542" /isTUend="FALSE" /label="downshifts" CDS 1317480..1319210 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall-binding protein" /protein_id="YP_003097723.1" /db_xref="EnsemblGenomes-Gn:BSU14071" /db_xref="EnsemblGenomes-Tr:CAX52614" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="UniProtKB/Swiss-Prot:O34320" /translation="MDEMVLLTQEWLNETYKGKSGYNSIEENGKTGWKTMYALTRALQ LELGITQTSDSFGPTTLRKLKELGPISTSTNSKKNIVKIIQGALYCKGYGPGGLTGTF GQGTKEAIAEMQLHMGLSKTDGVVTPKVFKALLNMDSYILLNGASEKVRSIQQWLNNK YYNRENFYFMPCDGLYSRDTQKSLVYAIQYEEGLSDSIANGNFGPTTQRLIPVLRIGE TDEKNSFIHLFQAALIFNGYNVPFDGVYSESVRSKVKAFQSFAKLQQSGTADFQTWAS LLVSTGDPNRKGVACDSITQITSDRAESLKRAGYKIVGRYLTNAPGSTLNKKIQPGEL ETILKSGLNVFPIYQTYGGATNYFNKEQGKKDAFAAYKAAKEYGFKNNTVIYFAVDYD AYGNDLNNNIIPHFEGINEIMNGFLGSTYKIGIYAPRNVCTIVSKKGLAFASFVSGMS TGFSGNLGYPLPYNWAFDQISTITVGNGSGMIEIDNDICSGLDNGVNTINIVPSENKK FFDQIDVLYETAEKYAQMQSDLNNGVKKTQLANELVAQYLRKDDYKGWKWVPTAGQID PIYREWAVKR*" /label="ykuG CDS" gene 1317480..1319210 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /label="ykuG gene" CDS 1319276..1319794 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097724.1" /db_xref="EnsemblGenomes-Gn:BSU14072" /db_xref="EnsemblGenomes-Tr:CAX52615" /db_xref="UniProtKB/Swiss-Prot:C0H408" /translation="MATYNAIIYSGGYSQTLRDFAGWTGDLLTTIQDMKLHAQEFNSP YDAAMKIIGNMYQFSLDDLFSDVDAINLANKTSVGANAQPLNIAIRDYYSNNDCMNRF TQFVNNRFDGSLDKIFSEAEYYLNTNLDPVVVPIRLAFKRAFDVEDYSEEIGKITAQA FRDVIEKKMISE*" /label="ykzU CDS" gene 1319276..1319794 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /label="ykzU gene" downshifts 1319792 /Source="Nicolas_upshifts" /id="D787" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.57306" /MaxDrop="3.8585" /score="8.20824413" /energy="-13" /TU="U1158,U1159" /idTUdmin="U1158" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 1319837..1319842 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1319855..1319874 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1319858 /Source="Nicolas_upshifts" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="upshifts" CDS 1319890..1320438 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389291.1" /db_xref="EnsemblGenomes-Gn:BSU14080" /db_xref="EnsemblGenomes-Tr:CAB13281" /db_xref="GOA:O31696" /db_xref="SubtiList:BG13292" /db_xref="UniProtKB/Swiss-Prot:O31696" /translation="MKKLLKKLVVLFLSSLVIIFNVWYFIICAFSPEYYQNTNLTSNE IIRFEKLYHIDFPDETKFIKAREYLAGPGGDTSAVLYVSLPTKRVEKVLSDYTYMKIN YTDNVGSMYGVDVSKSVAGLTTLTFGTYDKKGTFYNMKHDDDWMYKGTDWNLYFWTAA SYNAVIFVFVLVIVKQMNKILN*" /label="ykuH CDS" gene 1319890..1320438 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /label="ykuH gene" S_feature 1320439..1320590 /Source="Nicolas_S_feature" /locus_tag="new_1482096_1482247" /HighExp="HiOs, LPhT, Salt, T0.0H, HiTm, T-0.40H, Fru, T-1.10H, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S511" CDS 1320591..1321814 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19244251, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative cyclic-di-GMP receptor (no phosphodiesterase activity)" /protein_id="NP_389292.1" /db_xref="EnsemblGenomes-Gn:BSU14090" /db_xref="EnsemblGenomes-Tr:CAB13282" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR018842" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035919" /db_xref="PDB:2BAS" /db_xref="PDB:2W27" /db_xref="SubtiList:BG13293" /db_xref="UniProtKB/Swiss-Prot:O35014" /translation="MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEI QSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESF LELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSN LDRIALLSPDLLKIDLQALKVSQPSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQ YAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFY KRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWI YQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLF IDLPYSYLYEQDGLI*" /label="ykuI CDS" gene 1320591..1321814 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /label="ykuI gene" promotor_-10 complement(1321777..1321795) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1321787) /Source="Nicolas_upshifts" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1321793 /Source="Nicolas_upshifts" /id="D788" /incds=0 /nref=132 /ntot=229 /MaxReadThrough="3.48305" /MaxDrop="4.61382" /score="32.6727777" /energy="-7.5" /TU="U1159" /idTUdmin="U1160" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(1321810..1321815) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1321863..1321870 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1321882..1321983 /Source="Nicolas_S_feature" /locus_tag="new_1483539_1483640" /HighExp="B36, B60, nit, Pyr, BI, HiOs, T-0.40H, S5, GM 15, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S512" upshifts 1321882 /Source="Nicolas_upshifts" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1321885..1321904 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" misc_RNA 1321900..1321983 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /product="regulatory RNA controlling iron-dependent metabolism" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629, 24576839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629, 24576839; Product type n: RNA" /function="12: Regulatory functions" /label="fsrA RNA" gene 1321900..1321983 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /label="fsrA gene" downshifts 1321940 /Source="Nicolas_upshifts" /id="D789" /incds=0 /nref=61 /ntot=192 /MaxReadThrough="6.41968" /MaxDrop="7.54463" /score="16.5898261" /energy="-8.8" /TU="U1159,U1162" /idTUdmin="U1159" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 1321994..1321999 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1322014..1322298 /Source="Nicolas_S_feature" /locus_tag="new_1483671_1483955" /HighExp="S4, H2O2, S5, Paraq, B60, nit, GM 10, B36, GM 25, GM 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147452" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S513" upshifts 1322014 /Source="Nicolas_upshifts" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1322016..1322034 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-10" promotor_-35 1322275..1322281 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" promotor_-10 1322295..1322306 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" S_feature 1322300..1322387 /Source="Nicolas_S_feature" /locus_tag="new_1483957_1484044" /HighExp="S5, S4, H2O2, B60, Paraq, nit, B36, GM 10, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigEF, SigA" /TUshortPSig="0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S514" upshifts 1322300 /Source="Nicolas_upshifts" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" misc_feature 1322376..1322395 /Source="Nicolas_upshift_promotors" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1322389 /Source="Nicolas_upshifts" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1322460..1322699 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16387657, 18436958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-specific modification enzyme subunit" /protein_id="NP_389293.1" /db_xref="EnsemblGenomes-Gn:BSU14100" /db_xref="EnsemblGenomes-Tr:CAB13283" /db_xref="InterPro:IPR014904" /db_xref="PDB:2FFG" /db_xref="SubtiList:BG13294" /db_xref="UniProtKB/Swiss-Prot:O34588" /translation="MSQLMGIITRLQSLQETAEAANEPMQRYFEVNGEKICSVKYFEK NQTFELTVFQKGEKPNTYPFDNIDMVSIEIFELLQ*" /label="ykuJ CDS" gene 1322460..1322699 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /label="ykuJ gene" S_feature 1322700..1322808 /Source="Nicolas_S_feature" /locus_tag="new_1484357_1484465" /HighExp="H2O2, LoTm, G135, Paraq, G180, LBGexp, G150, Oxctl, dia0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S515" CDS 1322809..1323327 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16165328, 24464998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding enzyme component" /protein_id="NP_389294.1" /db_xref="EnsemblGenomes-Gn:BSU14110" /db_xref="EnsemblGenomes-Tr:CAB13284" /db_xref="InterPro:IPR007405" /db_xref="SubtiList:BG13295" /db_xref="UniProtKB/Swiss-Prot:O34776" /translation="MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDS QVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILD GHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDS YTAFSYANRFTK*" /label="ykuK CDS" gene 1322809..1323327 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /label="ykuK gene" promotor_-35 1323364..1323371 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1323385..1323404 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1323399 /Source="Nicolas_upshifts" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1323461..1323658 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18840696, 24534728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18840696, 24534728; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of AbrB repressor" /protein_id="NP_389295.1" /db_xref="EnsemblGenomes-Gn:BSU14120" /db_xref="EnsemblGenomes-Tr:CAB13285" /db_xref="GOA:O31697" /db_xref="InterPro:IPR025446" /db_xref="PDB:2LZF" /db_xref="SubtiList:BG13334" /db_xref="UniProtKB/Swiss-Prot:O31697" /translation="MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTK NVDGTTYKKLVTLYDRFRFEN*" /label="abbA CDS" gene 1323461..1323658 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /label="abbA gene" downshifts 1323654 /Source="Nicolas_upshifts" /id="D790" /incds=0 /nref=114 /ntot=265 /MaxReadThrough="5.72556" /MaxDrop="4.65809" /score="2.45376472" /energy="-6.8" /TU="U1165,U1166" /idTUdmin="U1162" /TUdmin=12 /isTUend="TRUE" /label="downshifts" S_feature 1323699..1323795 /Source="Nicolas_S_feature" /locus_tag="new_1485356_1485452" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, M0t90, T1.0H, T5.0H, T2.30H, T1.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.23094000000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S516" CDS 1323796..1324239 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11985717; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA-binding protein" /protein_id="NP_389296.1" /db_xref="EnsemblGenomes-Gn:BSU14130" /db_xref="EnsemblGenomes-Tr:CAB13286" /db_xref="PDB:1YAV" /db_xref="SubtiList:BG13296" /db_xref="UniProtKB/Swiss-Prot:O31698" /translation="MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTG YTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDP IMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK*" /label="ykuL CDS" gene 1323796..1324239 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /label="ykuL gene" S_feature 1324240..1324347 /Source="Nicolas_S_feature" /locus_tag="new_1485897_1486004" /HighExp="M0t90, M40t90, M9-stat, T1.0H, T3.30H, T3.0H, T4.0H, S2, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S517" promotor_-35 1324315..1324320 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1324335..1324354 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1324349 /Source="Nicolas_upshifts" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1324388..1325269 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14636591, 16352834, 16395550, 23139400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636591, 16352834, 16395550, 23139400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of citB and citZ" /protein_id="NP_389297.1" /db_xref="EnsemblGenomes-Gn:BSU14140" /db_xref="EnsemblGenomes-Tr:CAB13287" /db_xref="GOA:O34827" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13297" /db_xref="UniProtKB/Swiss-Prot:O34827" /translation="MQLQELHMLVVLAEELNMRKAAERLFVSQPALSQRLQTIEKAWG TKIFLRSQKGLTVTPAGEKIIQFANDVTLEQERIRENIDELEGEIHGTLKLAVASIIG QHWLPKVLKTYVEKYPNAKISLITGWSSEMLKSLYEDQVHIGIIRGNPEWKGRKDYLM TDHLYLVDTEISCIEDIAHTERPFIQFKSDSTYFQEIQHWWHQKFKTSPKQTILVDQI ETCKQMALHGIGYAILPSVTLQNEDKVNKMPLLDMKGHPIGRDTWLLGYEPAFELKQV QAFVQVIKDMLDQENPF*" /label="ccpC CDS" gene 1324388..1325269 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /label="ccpC gene" downshifts 1325248 /Source="Nicolas_upshifts" /id="D791" /incds=0 /nref=168 /ntot=242 /MaxReadThrough="1.76921" /MaxDrop="5.2505" /score="37.6563581" /energy="-8.3" /TU="NA" /idTUdmin="U1165" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1325304..1325311 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1325326..1325345 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1325331 /Source="Nicolas_upshifts" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1325381..1325857 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin (acts in lipid desaturation)" /protein_id="NP_389298.1" /db_xref="EnsemblGenomes-Gn:BSU14150" /db_xref="EnsemblGenomes-Tr:CAB13288" /db_xref="GOA:O34737" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13298" /db_xref="UniProtKB/Swiss-Prot:O34737" /translation="MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDAS CLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAV NLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS*" /label="fldN CDS" gene 1325381..1325857 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /label="fldN gene" CDS 1325847..1326740 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12354229, 24214949" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389299.1" /db_xref="EnsemblGenomes-Gn:BSU14160" /db_xref="EnsemblGenomes-Tr:CAB13289" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG13299" /db_xref="UniProtKB/Swiss-Prot:O34879" /translation="MFHKGATAVTASAFSGYFVAVQREGIFHYSLEQGWRKLFRLKSK IHCISYIGPYLFGVGEKGTVIRSADEGKTWTMSSFPTNATVWAITGRNNGFVCAHGKH CIYVSDDFGVSWRVAKPFAEFHNPPVIRSLCLHGGNLFIGTQIHEYFGGIWAYDIKRD TVQVVKKEKNRMTASMLVFNENWLVAAMGSVKGKHGAVTVRNLLNGEEFTIQSSMIRN EESFLDLSEDDGIIYVTTTQDENGFSRIYQVDLEARSLKWFDTIKGHGWRVANQKENF FCAGLYECKFVQPYEVSAMIH*" /label="ykuO CDS" gene 1325847..1326740 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /label="ykuO gene" CDS 1326756..1327211 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin" /protein_id="NP_389300.2" /db_xref="EnsemblGenomes-Gn:BSU14170" /db_xref="EnsemblGenomes-Tr:CAB13290" /db_xref="GOA:O34589" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001226" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13300" /db_xref="UniProtKB/Swiss-Prot:O34589" /translation="MAKILLVYATMSGNTEAMADLIEKGLQEALAEVDRFEAMDIDDA QLFTDYDHVIMGTYTWGDGDLPDEFLDLVEDMEEIDFSGKTCAVFGSGDTAYEFFCGA VDTLEAKIKERGGDIVLPSVKIENNPEGEEEEELINFGRQFAKKSGCAV*" /label="fldP CDS" gene 1326756..1327211 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /label="fldP gene" promotor_-10 complement(1327027..1327046) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1327040) /Source="Nicolas_upshifts" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1327060..1327068) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1327205 /Source="Nicolas_upshifts" /id="D792" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="6.48855" /MaxDrop="3.75748" /score="20.7202933" /energy="-9" /TU="U1168" /idTUdmin="U1165" /TUdmin=1957 /isTUend="FALSE" /label="downshifts" promotor_-35 1327250..1327257 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1327271..1327290 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1327272 /Source="Nicolas_upshifts" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1327316..1328026 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /EC_number="2.3.1.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5411754, 10368155, 11910040, 12682299, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5411754, 10368155, 11910040, 12682299, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetrahydrodipicolinate N-acetyltransferase" /protein_id="NP_389301.2" /db_xref="EnsemblGenomes-Gn:BSU14180" /db_xref="EnsemblGenomes-Tr:CAB13291" /db_xref="GOA:O34981" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR013710" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR019873" /db_xref="SubtiList:BG13301" /db_xref="UniProtKB/Swiss-Prot:O34981" /translation="MKMMDANEIISFIQNSTKSTPVKVYVKGELEGINFGESAKAFIN GNTGVVFGEWSEIQTAIEENQSKIEDYVVENDRRNSAIPMLDLKNIKARIEPGAIIRD QVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEP PSAKPVVIEDDVVIGANAVVLEGVTVGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKD IDEKTKGKTEIKQELRQL*" /label="dapH CDS" gene 1327316..1328026 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /label="dapH gene" downshifts complement(1327325) /Source="Nicolas_upshifts" /id="D793" /incds=0 /nref=60 /ntot=165 /MaxReadThrough="1.03272" /MaxDrop="4.75802" /score="28.9046709" /energy="-15" /TU="NA" /idTUdmin="U1171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1327435..1327439) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1327435) /Source="Nicolas_upshifts" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1328096..1329220 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /EC_number="3.5.1.47" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14627808, 17093042, 24261876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14627808, 17093042, 24261876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-diaminopimelate deacetylase" /protein_id="NP_389302.1" /db_xref="EnsemblGenomes-Gn:BSU14190" /db_xref="EnsemblGenomes-Tr:CAB13292" /db_xref="GOA:O34916" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR023905" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13302" /db_xref="UniProtKB/Swiss-Prot:O34916" /translation="MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEI EKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTI ALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELP VGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTD PLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFR CKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGF MFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN*" /label="dapI CDS" gene 1328096..1329220 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /label="dapI gene" promotor_-35 1329232..1329238 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1329252..1329263 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1329254 /Source="Nicolas_upshifts" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1329258..1329272) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1329282..1329286) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1329282..1329527 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389303.1" /db_xref="EnsemblGenomes-Gn:BSU14200" /db_xref="EnsemblGenomes-Tr:CAB13293" /db_xref="InterPro:IPR005370" /db_xref="SubtiList:BG13303" /db_xref="UniProtKB/Swiss-Prot:O34783" /translation="MAKKIGIEQSLSDVEAALKEKGYDVVMMKSPADAQGCDCCVVTG LDNNVQGIADTVTQAPVITASGMTAEEICSEVESRIQ*" /label="ykuS CDS" gene 1329282..1329527 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /label="ykuS gene" upshifts complement(1329283) /Source="Nicolas_upshifts" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1329515 /Source="Nicolas_upshifts" /id="D794" /incds=0 /nref=238 /ntot=269 /MaxReadThrough="3.49553" /MaxDrop="5.88829" /score="3.56597112" /energy="-9.9" /TU="U1172" /idTUdmin="U1168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1329560..1330510 /Source="Nicolas_S_feature" /locus_tag="new_1491217_1492167" /HighExp="S4, S5, S6, S3, S7, S8, LoTm, BT, B36, G135" /AntisenseName="ykuT" /AntisenseCor="-0.479447808227356" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S518" CDS complement(1329564..1330367) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /function="16.6: Maintain" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12626684, 17665170, 18310427, 19252899, 21150093" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12626684, 17665170, 18310427, 19252899, 21150093; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small-conductance mechanosensitive channel" /protein_id="NP_389304.2" /db_xref="EnsemblGenomes-Gn:BSU14210" /db_xref="EnsemblGenomes-Tr:CAB13294" /db_xref="GOA:O34897" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13304" /db_xref="UniProtKB/Swiss-Prot:O34897" /translation="MDFIKQYDWAGLITNAGVLLIKLAIMILLYFIVRSLGMKIIKHL FAKFEEQNSLSIGRAHTLRSLTLNIFAYTLIFIFFVMVLDLFHYDPSALLAGAGIVGL AVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVSTFDGIVEQVGLRTTQIRSFDGTLH YIPNRNITNVSNHSRGTMQALVDIKVPAERNIDEMIHILQQVCDETAAALPQIKEGPN VIGIQELGTSEIVIRVIAKTENMEQWRVERVLRKEIKNAFDRAFPKETE*" /label="mscT CDS" gene complement(1329564..1330367) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /label="mscT gene" downshifts complement(1329576) /Source="Nicolas_upshifts" /id="D795" /incds=0 /nref=16 /ntot=131 /MaxReadThrough="1.65551" /MaxDrop="4.4361" /score="29.0050313" /energy="-9.9" /TU="NA" /idTUdmin="U1174" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1330418..1330437) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1330427) /Source="Nicolas_upshifts" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1330451..1330458) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1330483..1330490 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-35" promotor_-10 1330505..1330524 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-10" S_feature 1330512..1330603 /Source="Nicolas_S_feature" /locus_tag="new_1492169_1492260" /HighExp="LPhT, Salt, Etha, M9-stat, M0t90, T4.0H, T5.0H, S4, Heat, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S519" upshifts 1330512 /Source="Nicolas_upshifts" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="upshifts" CDS 1330604..1331146 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /EC_number="1.11.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:22938038, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22938038, 27683249; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biofilm-specific peroxidase; 2-cys peroxiredoxin" /protein_id="NP_389305.1" /db_xref="EnsemblGenomes-Gn:BSU14220" /db_xref="EnsemblGenomes-Tr:CAB13295" /db_xref="GOA:O34564" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13305" /db_xref="UniProtKB/Swiss-Prot:O34564" /translation="MAERMVGKQAPRFEMEAVLASKEFGKVSLEENMKNDKWTVLFFY PMDFTFVCPTEITAMSDRYDEFEDLDAEVIGVSTDTIHTHLAWINTDRKENGLGQLKY PLAADTNHEVSREYGVLIEEEGVALRGLFIINPEGELQYQTVFHNNIGRDVDETLRVL QALQTGGLCPANWKPGQKTL*" /label="ahpA CDS" gene 1330604..1331146 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /label="ahpA gene" CDS 1331218..1331664 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /EC_number="1.8.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15937154, 16132829, 16418167" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 16132829, 16418167; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_389306.2" /db_xref="EnsemblGenomes-Gn:BSU14230" /db_xref="EnsemblGenomes-Tr:CAB13296" /db_xref="GOA:O31699" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:2B5X" /db_xref="PDB:2B5Y" /db_xref="SubtiList:BG13306" /db_xref="UniProtKB/Swiss-Prot:O31699" /translation="MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLC KEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHAL TDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE*" /label="ykuV CDS" gene 1331218..1331664 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /label="ykuV gene" downshifts 1331672 /Source="Nicolas_upshifts" /id="D796" /incds=0 /nref=58 /ntot=211 /MaxReadThrough="3.11112" /MaxDrop="4.73023" /score="10.8864177" /energy="-5.4" /TU="U1175" /idTUdmin="U1172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1332057..1332064 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1332077 /Source="Nicolas_upshifts" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1332079..1332098 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1332130..1332705 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 27902860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 27902860; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of comK" /protein_id="NP_389307.1" /db_xref="EnsemblGenomes-Gn:BSU14240" /db_xref="EnsemblGenomes-Tr:CAB13297" /db_xref="GOA:O34857" /db_xref="SubtiList:BG13307" /db_xref="UniProtKB/Swiss-Prot:O34857" /translation="MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNG SPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDG TTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQ SLIKMYPEVKKPYRGQYILEGEIESAESANE*" /label="rok CDS" gene 1332130..1332705 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /label="rok gene" downshifts 1332683 /Source="Nicolas_upshifts" /id="D797" /incds=0 /nref=246 /ntot=258 /MaxReadThrough="1.77207" /MaxDrop="6.35121" /score="17.7584572" /energy="-9" /TU="NA" /idTUdmin="U1176" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1332746..1333711) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /experiment="publication(s) with functional evidences, PMID:8990290, 15383836, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 15383836, 15743949; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein cse15" /protein_id="NP_389308.1" /db_xref="EnsemblGenomes-Gn:BSU14250" /db_xref="EnsemblGenomes-Tr:CAB13298" /db_xref="GOA:O31700" /db_xref="SubtiList:BG12251" /db_xref="UniProtKB/Swiss-Prot:O31700" /translation="MKRSGPFFHDVSQENLYLKSELSRCHKLISELEASYFHQKNNKL LKENTDMKEKLQQLSAELTHMSTKEKHASHTSQTLHQIRAELLDKIVVLQELLSAETY KRRAEIEEKHKLHIAKVKIEEENKNLHKRISELQASIEQEQNALLQAKQQAELIKAEN GRLKEQMVEKEYQLKHIKIEVDHMKDRIIETKERLLDIEKTKEKLFHETIISYKRQLD ESDAWIASHFADIDGGTKQKEKTEEEAPAAYAQPNHVETILEDVTKQIHVLQKQLAHA QSSDQAKSHTIEELKNRAAEEKPYQKWVYKLNLEKENKPSQKKPQ*" /label="sppO CDS" gene complement(1332746..1333711) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /label="sppO gene" downshifts complement(1332759) /Source="Nicolas_upshifts" /id="D798" /incds=0 /nref=47 /ntot=67 /MaxReadThrough="2.24884" /MaxDrop="5.5936" /score="3.60334458" /energy="-7.2" /TU="NA" /idTUdmin="U1178" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1333055..1333056 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1333074..1333093 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1333080..1333804 /Source="Nicolas_S_feature" /locus_tag="new_1494737_1495461" /HighExp="dia15, Diami, dia5, H2O2, G135, G150, G180, LBGexp, Paraq, Lbexp" /AntisenseName="yknT" /AntisenseCor="-0.36512493899072102" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S520" upshifts 1333080 /Source="Nicolas_upshifts" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1333732..1333750) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1333753) /Source="Nicolas_upshifts" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1333765..1333770) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1333791..1333797 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1333807 /Source="Nicolas_upshifts" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1333811..1333830 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1333848..1334447 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /EC_number="2.7.7.77" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10978347; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein A" /protein_id="NP_389309.1" /db_xref="EnsemblGenomes-Gn:BSU14260" /db_xref="EnsemblGenomes-Tr:CAB13299" /db_xref="GOA:O31701" /db_xref="InterPro:IPR013482" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12621" /db_xref="UniProtKB/Swiss-Prot:O31701" /translation="MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVI ISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQR RTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRI SVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD*" /label="mobA CDS" gene 1333848..1334447 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /label="mobA gene" CDS 1334498..1335517 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /EC_number="2.7.7.80" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17223713; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin biosynthesis adenylyltransferase" /protein_id="NP_389310.1" /db_xref="EnsemblGenomes-Gn:BSU14270" /db_xref="EnsemblGenomes-Tr:CAB13300" /db_xref="GOA:O31702" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG12624" /db_xref="UniProtKB/Swiss-Prot:O31702" /translation="MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLS RAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYV TEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVI PGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFV TFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESL KRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLA RVIGL*" /label="moeB CDS" gene 1334498..1335517 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /label="moeB gene" CDS 1335535..1336827 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /EC_number="2.10.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11428898, 12006571, 18959753, 21206014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdate to molybdopterin ligation enzyme" /protein_id="NP_389311.1" /db_xref="EnsemblGenomes-Gn:BSU14280" /db_xref="EnsemblGenomes-Tr:CAB13301" /db_xref="GOA:O31703" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR005110" /db_xref="InterPro:IPR005111" /db_xref="InterPro:IPR036135" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036688" /db_xref="SubtiList:BG12623" /db_xref="UniProtKB/Swiss-Prot:O31703" /translation="MLEKRTPIPVDEAVRRVCHFQKQGETEWVALEDSLHRFLAEDIT ADHHVPAFDRSPYDGFAVRACDTAEASRENPVRFEVIDHIGAGAVSEKELGPFQAVRI MTGAQIPEGADAVVMIELTQAFEENGKSFMSLKRRFQTGDNISKTGEDAQKGSVLLTK GTRVTPGVTALLATFGYASVPVVRKPVVGIIATGTELLNVSDPLEPGKIRNSNASMVY AQAIEAGATPLYLGKISDELDKSFAAVKEAMKKVDFLITTGGVSVGDFDFLPAIYEKL GADVLFNKVAMRPGSVTTVAHANDMLLFGLSGNPSACYVGFELFVKPIIQTWLLNETP HSICAEAVLTKDFPKPNPFTRFVRALVHHQEGKLLATPVGLDKSSSVTSLADANAFII LPGGTRGYESGRTVQVLLIREENGSEWPWSVLSRSSKL*" /label="moeA CDS" gene 1335535..1336827 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /label="moeA gene" CDS 1336788..1337309 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9219527, 12682065, 12719427; Product type c: carrier" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein B" /protein_id="NP_389312.1" /db_xref="EnsemblGenomes-Gn:BSU14290" /db_xref="EnsemblGenomes-Tr:CAB13302" /db_xref="GOA:O31704" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12622" /db_xref="UniProtKB/Swiss-Prot:O31704" /translation="MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHH GHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDC LLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVA VDFVLSQLKGESA*" /label="mobB CDS" gene 1336788..1337309 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /label="mobB gene" CDS 1337309..1337782 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /EC_number="2.8.1.12" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 18092812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (large subunit)" /protein_id="NP_389313.1" /db_xref="EnsemblGenomes-Gn:BSU14300" /db_xref="EnsemblGenomes-Tr:CAB13303" /db_xref="GOA:O31705" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR036563" /db_xref="SubtiList:BG12620" /db_xref="UniProtKB/Swiss-Prot:O31705" /translation="MERFEITKTPINTENIIKKVEKREAGAITTFIGTVREWTNGKRT VRLEYEAYEPMAVQMLAQIGAEIEEKWEGASAAITHRIGVLDIGEAAVVIAVSSPHRK AAYEANEYAIERIKQIVPIWKKEIWEDGEQWIGDQLETTAYPNGKPDLSEGEQHD*" /label="moaE CDS" gene 1337309..1337782 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /label="moaE gene" CDS 1337775..1338008 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 17223713, 19946146; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (small subunit)" /protein_id="NP_389314.1" /db_xref="EnsemblGenomes-Gn:BSU14310" /db_xref="EnsemblGenomes-Tr:CAB13304" /db_xref="GOA:O31706" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="SubtiList:BG12619" /db_xref="UniProtKB/Swiss-Prot:O31706" /translation="MIKILLFAGLAEQAGTQAIEIDMEQATTDEIKASLKEQYGLESI DTAMIAVNESYVKENTSVSSGDTVAIIPPVSGG*" /label="moaD CDS" gene 1337775..1338008 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /label="moaD gene" downshifts 1337987 /Source="Nicolas_upshifts" /id="D799" /incds=0 /nref=87 /ntot=240 /MaxReadThrough="1.14308" /MaxDrop="5.73073" /score="32.0123217" /energy="-16.9" /TU="NA" /idTUdmin="U1177" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1338053..1338058 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-35" promotor_-10 1338075..1338093 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-10" upshifts 1338083 /Source="Nicolas_upshifts" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="upshifts" S_feature 1338095..1338181 /Source="Nicolas_S_feature" /locus_tag="new_1499752_1499838" /HighExp="S4, S5, S3, T5.0H, T4.0H, Pyr, S6, T3.30H, M9-stat, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S521" promotor_-35 1338171..1338174 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1338183 /Source="Nicolas_upshifts" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1338189..1338208 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1338232..1339989 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389315.1" /db_xref="EnsemblGenomes-Gn:BSU14320" /db_xref="EnsemblGenomes-Tr:CAB13305" /db_xref="GOA:O31707" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13241" /db_xref="UniProtKB/Swiss-Prot:O31707" /translation="METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITID EIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRL SFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTL VTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQI STFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELV AFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGD VHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGM ITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQ AHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTE HSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKK IYDLQYRDVKMINEPHEVG*" /label="yknU CDS" gene 1338232..1339989 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /label="yknU gene" CDS 1340001..1341815 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389316.1" /db_xref="EnsemblGenomes-Gn:BSU14330" /db_xref="EnsemblGenomes-Tr:CAB13306" /db_xref="GOA:O31708" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13242" /db_xref="UniProtKB/Swiss-Prot:O31708" /translation="MKQAKKQGVLERFYYSSDEIIEKPFNWAQMWRLLSYVKPYRKTI LPLSFLTVLIGTAVKLVIPILIGVYVLDQAITGRNSELLIQLIFIISGLYVLNYAANV LRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQRSAGSILVRIMNDINSLQELFTS GVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMFFISTSLRKKIRRSWQTVRLK QSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYESWREATRKNAMFRPLVEM TNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPISRLGQVYNQLLMGMASS ERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKALHAVSFSIPAGSTL ALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQISIVLQDTFIFS GTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGSVLSAGQRQLI SFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRLSTIRDADR IIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQYSTAIE*" /label="yknV CDS" gene 1340001..1341815 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /label="yknV gene" promotor_-10 complement(1340438..1340457) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1340448) /Source="Nicolas_upshifts" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1340472..1340479) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1341866..1341875 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1341887..1341902 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1341891 /Source="Nicolas_upshifts" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="upshifts" CDS 1341925..1342620 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of permease exporting the starvation-induced killing protein" /protein_id="NP_389317.1" /db_xref="EnsemblGenomes-Gn:BSU14340" /db_xref="EnsemblGenomes-Tr:CAB13307" /db_xref="GOA:O31709" /db_xref="InterPro:IPR006977" /db_xref="SubtiList:BG13243" /db_xref="UniProtKB/Swiss-Prot:O31709" /translation="METNVEKNSGTATEKPSLFGVITSPSVQFERIRERPAVWGPLLI VAAIIIVGAVLQSLGTDYSELLKSQDTQGLSAEQMETVATITKFGGMAGAIIGGIAAL FIAPLIYWLCVKVSGGVTTYKKMLSLSLFVSLISSLGLLVNGIVAFTTDVNPLYSTTS LAGIIPSDGALASVLNTFEIFSIWSFVLLAIGLHKTGGISKKAGWISAIILFGILVVF SLFSGLINSVAGA*" /label="skiW CDS" gene 1341925..1342620 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /label="skiW gene" CDS 1342625..1343758 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11544226, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544226, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein" /protein_id="NP_389318.1" /db_xref="EnsemblGenomes-Gn:BSU14350" /db_xref="EnsemblGenomes-Tr:CAB13308" /db_xref="GOA:O31710" /db_xref="InterPro:IPR006143" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG13244" /db_xref="UniProtKB/Swiss-Prot:O31710" /translation="MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEE NEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLE KEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKT AEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKD LVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQA VQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKA KRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS*" /label="skiX CDS" gene 1342625..1343758 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /label="skiX gene" CDS 1343759..1344451 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein (ATP-binding protein)" /protein_id="NP_389319.1" /db_xref="EnsemblGenomes-Gn:BSU14360" /db_xref="EnsemblGenomes-Tr:CAB13309" /db_xref="GOA:O31711" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13245" /db_xref="UniProtKB/Swiss-Prot:O31711" /translation="MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGK STIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKK NVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEP KLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNI VPASSGQRSVGE*" /label="skiY CDS" gene 1343759..1344451 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /label="skiY gene" CDS 1344448..1345641 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703, 22720735, 27243566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703, 22720735, 27243566; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease subunit exporting Sporulation-Delaying Protein" /protein_id="NP_389320.1" /db_xref="EnsemblGenomes-Gn:BSU14370" /db_xref="EnsemblGenomes-Tr:CAB13310" /db_xref="GOA:O31712" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR005085" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13246" /db_xref="UniProtKB/Swiss-Prot:O31712" /translation="MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQG GEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVA STSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKM AKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDF SNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIG SIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGG LVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIE ALRYE*" /label="skiZ CDS" gene 1344448..1345641 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /label="skiZ gene" downshifts 1345619 /Source="Nicolas_upshifts" /id="D800" /incds=0 /nref=79 /ntot=210 /MaxReadThrough="3.49546" /MaxDrop="4.46952" /score="36.2703425" /energy="-12.1" /TU="U1183" /idTUdmin="U1183" /TUdmin="-396" /isTUend="FALSE" /label="downshifts" promotor_-35 1345690..1345696 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1345710..1345721 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1345718 /Source="Nicolas_upshifts" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1345763..1345770 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-35" promotor_-10 1345785..1345804 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-10" S_feature 1345790..1345881 /Source="Nicolas_S_feature" /locus_tag="new_1507447_1507538" /HighExp="UNK1, LPh, HPh, Fru, G180, MG 5, C30, G135, MG t5, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigWXY" /TUshortPSig="0.967, 0.86, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S522" upshifts 1345790 /Source="Nicolas_upshifts" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="upshifts" promotor_-35 1345845..1345852 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1345866..1345885 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1345883 /Source="Nicolas_upshifts" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="upshifts" CDS 1345921..1346676 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563858; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (DeoR family)" /protein_id="NP_389321.1" /db_xref="EnsemblGenomes-Gn:BSU14380" /db_xref="EnsemblGenomes-Tr:CAB13311" /db_xref="GOA:O31713" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12589" /db_xref="UniProtKB/Swiss-Prot:O31713" /translation="MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLE ERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGT TTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAM DQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSA FAGIGDATIITTDAEELTFDNYQEKTVVKVVKP*" /label="fruR CDS" gene 1345921..1346676 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /label="fruR gene" upshifts complement(1346069) /Source="Nicolas_upshifts" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1346071..1346073) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1346673..1347584 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /EC_number="2.7.1.56" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 168069, 14563858, 24328040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1-phosphate kinase" /protein_id="NP_389322.1" /db_xref="EnsemblGenomes-Gn:BSU14390" /db_xref="EnsemblGenomes-Tr:CAB13312" /db_xref="GOA:O31714" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR017583" /db_xref="InterPro:IPR022463" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12588" /db_xref="UniProtKB/Swiss-Prot:O31714" /translation="MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSR LLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEIN GQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVL DISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSM AGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSG SATAFSEELGTEEFVQQLLPEVKVTRL*" /label="fruK CDS" gene 1346673..1347584 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /label="fruK gene" CDS 1347599..1349506 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /EC_number="2.7.1.202" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:118007, 200418" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 118007, 200418; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIABC component" /protein_id="NP_389323.1" /db_xref="EnsemblGenomes-Gn:BSU14400" /db_xref="EnsemblGenomes-Tr:CAB13313" /db_xref="GOA:P71012" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R4Q" /db_xref="SubtiList:BG11938" /db_xref="UniProtKB/Swiss-Prot:P71012" /translation="MKITELLTKHTIKLNIESKEKENVIDEMVTVLDKAGKLNDRQAY KEAILNRESQSSTGIGEGIAIPHAKTASVINPAIAFGRSKDGVDYESLDGQPAHLVFM IAATEGANNTHLEALSRLSTLLMREEIRKQLLEAESEDAIIDIINQHDKDDDEEEEEE EAAPAPAGKGKILAVTACPTGIAHTFMAADALKEKAKELGVEIKVETNGSSGIKHKLT AQEIEDAPAIIVAADKQVEMERFKGKRVLQVPVTAGIRRPQELIEKAMNQDAPIYQGS GGGSAASNDDEEAKGKSGSGIGNTFYKHLMSGVSNMLPFVVGGGILVAISFFWGIHSA DPNDPSYNTFAAALNFIGGDNALKLIVAVLAGFIAMSIADRPGFAPGMVGGFMATQAN AGFLGGLIAGFLAGYVVILLKKVFTFIPQSLDGLKPVLIYPLFGIFITGVLMQFVVNT PVAAFMNFLTNWLESLGTGNLVLMGIILGGMMAIDMGGPLNKAAFTFGIAMIDAGNYA PHAAIMAGGMVPPLGIALATTIFRNKFTQRDREAGITCYFMGAAFVTEGAIPFAAADP LRVIPAAVVGAAVAGGLTEFFRVTLPAPHGGVFVAFITNHPMLYLLSIVIGAVVMAII LGIVKKPVTEK*" /label="fruA CDS" gene 1347599..1349506 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /label="fruA gene" downshifts 1349491 /Source="Nicolas_upshifts" /id="D801" /incds=0 /nref=133 /ntot=228 /MaxReadThrough="3.99928" /MaxDrop="5.27169" /score="11.7516734" /energy="-11.4" /TU="U1185" /idTUdmin="U1186" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1349575..1349582 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1349593..1349612 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1349596 /Source="Nicolas_upshifts" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="upshifts" CDS 1349651..1350232 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11283286, 11807061, 12897006, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11283286, 11807061, 12897006, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_389324.1" /db_xref="EnsemblGenomes-Gn:BSU14410" /db_xref="EnsemblGenomes-Tr:CAB13314" /db_xref="GOA:P71013" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11977" /db_xref="UniProtKB/Swiss-Prot:P71013" /translation="MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEP YLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGET VQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK*" /label="sipT CDS" gene 1349651..1350232 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /label="sipT gene" downshifts 1350217 /Source="Nicolas_upshifts" /id="D802" /incds=0 /nref=90 /ntot=226 /MaxReadThrough="3.7981" /MaxDrop="6.13957" /score="5.03270493" /energy="-9.8" /TU="U1188" /idTUdmin="U1188" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1350261 /Source="Nicolas_upshifts" /id="D803" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.6676" /MaxDrop="3.60225" /score="5.03270493" /energy="-9.8" /TU="NA" /idTUdmin="U1188" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1350266..1350535) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389325.1" /db_xref="EnsemblGenomes-Gn:BSU14420" /db_xref="EnsemblGenomes-Tr:CAB13315" /db_xref="GOA:O31715" /db_xref="SubtiList:BG13247" /db_xref="UniProtKB/Swiss-Prot:O31715" /translation="MRLLTLTEYCLLIFFTGFYLAVTGFTAKDIGLYIGIALIYIFSH IFSKRLLEKRGKENKQVHLFFSVLAIIGSVFITVLCIALVASFSK*" /label="ykoA CDS" gene complement(1350266..1350535) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /label="ykoA gene" downshifts complement(1350271) /Source="Nicolas_upshifts" /id="D804" /incds=0 /nref=38 /ntot=254 /MaxReadThrough="2.08491" /MaxDrop="5.70938" /score="11.210199" /energy="-9.8" /TU="U1189" /idTUdmin="U1189" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(1350536..1350601) /Source="Nicolas_S_feature" /locus_tag="new_1512193_1512258_c" /HighExp="LoTm, Gly, Lbstat, Sw, Cold, C30, HPh, S0, T0.30H, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S523" misc_feature complement(1350582..1350601) /Source="Nicolas_upshift_promotors" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1350601) /Source="Nicolas_upshifts" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1350654..1350661 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1350672..1350691 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1350676 /Source="Nicolas_upshifts" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="upshifts" CDS 1350716..1352338 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10816464, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_389326.1" /db_xref="EnsemblGenomes-Gn:BSU14430" /db_xref="EnsemblGenomes-Tr:CAB13316" /db_xref="GOA:O31716" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG13270" /db_xref="UniProtKB/Swiss-Prot:O31716" /translation="MIAVNNVSLRFADRKLFEDVNIKFTPGNCYGLIGANGAGKSTFL KVLSGEIEPQTGDVHMSPGERLAVLKQNHFEYEEYEVLKVVIMGHKRLYEVMQEKDAI YMKPDFSDEDGIRAAELEGEFAELNGWEAESEAAILLKGLGISEDLHTKKMADLGGSE KVKVLLAQALFGKPDVLLLDEPTNHLDLQAIQWLEEFLINFENTVIVVSHDRHFLNKV CTHIADLDFNKIQIYVGNYDFWYESSQLALKLSQEANKKKEEQIKQLQEFVARFSANA SKSKQATSRKKLLEKITLDDIKPSSRRYPYVNFTPEREIGNDVLRVEGLTKTIDGVKV LDNVSFIMNREDKIAFTGRNELAVTTLFKIISGEMEADSGTFKWGVTTSQAYFPKDNS EYFEGSDLNLVDWLRQYSPHDQSESFLRGFLGRMLFSGEEVHKKANVLSGGEKVRCML SKAMLSGANILILDEPTNHLDLESITALNNGLISFKGAMLFTSHDHQFVQTIANRIIE ITPNGIVDKQMSYDEFLENADVQKKLTELYAE*" /label="ykpA CDS" gene 1350716..1352338 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /label="ykpA gene" downshifts 1352326 /Source="Nicolas_upshifts" /id="D805" /incds=0 /nref=45 /ntot=239 /MaxReadThrough="5.13671" /MaxDrop="3.6227" /score="17.6386925" /energy="-7.6" /TU="U1190" /idTUdmin="U1190" /TUdmin="-993" /isTUend="FALSE" /label="downshifts" CDS 1352395..1353306 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 15966718, 17229734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate reductase" /protein_id="NP_389327.1" /db_xref="EnsemblGenomes-Gn:BSU14440" /db_xref="EnsemblGenomes-Tr:CAB13317" /db_xref="GOA:O31717" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13271" /db_xref="UniProtKB/Swiss-Prot:O31717" /translation="MKFLVVGAGGVGGYIGGRLSEKGNDVTFLVRQKRAEQLKKTGLV IHSEKGNVSFQPELISAGETGQFDVVIIASKAYSLGQVIEDVKPFIHQESVIIPFLNG YRHYEQLFAAFSKEQVLGGLCFIESALDNKGEIHHTSASHRFVFGEWNGERTERIRAL EEAFSGVKAEVIISGHIEKDIWKKYLFIAAQAGITTLFQRPLGPILATEAGRHTAQTL IGEICTVLRKEGVPADPALEEESFRTMTSMSYHMKSSMLRDMENGQTTEGDHLHGFLI EKAKRLSLAAPVLETVYANLQMYEAEK*" /label="panE CDS" gene 1352395..1353306 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /label="panE gene" downshifts 1353311 /Source="Nicolas_upshifts" /id="D806" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="2.04919" /MaxDrop="4.55439" /score="11.4959806" /energy="-9.6" /TU="NA" /idTUdmin="U1190" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1353340..1354572) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /EC_number="3.4.11.24" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9362117, 16088219, 22808738" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9362117, 16088219, 22808738; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase" /protein_id="NP_389328.1" /db_xref="EnsemblGenomes-Gn:BSU14450" /db_xref="EnsemblGenomes-Tr:CAB13318" /db_xref="GOA:P39762" /db_xref="InterPro:IPR000787" /db_xref="InterPro:IPR035097" /db_xref="SubtiList:BG10986" /db_xref="UniProtKB/Swiss-Prot:P39762" /translation="MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIV KHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVV SSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGK SEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTD LTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNI IENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFY NTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDG ITADGKREPIFRNGNWAF*" /label="ampS CDS" gene complement(1353340..1354572) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /label="ampS gene" downshifts complement(1353351) /Source="Nicolas_upshifts" /id="D807" /incds=0 /nref=215 /ntot=254 /MaxReadThrough="1.34101" /MaxDrop="5.7635" /score="40.7811053" /energy="-9.6" /TU="NA" /idTUdmin="U1191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1354590..1354609) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1354614) /Source="Nicolas_upshifts" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1354624..1354629) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1354682..1354816) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389329.1" /db_xref="EnsemblGenomes-Gn:BSU14460" /db_xref="EnsemblGenomes-Tr:CAB13319" /db_xref="InterPro:IPR035379" /db_xref="SubtiList:BG11812" /db_xref="UniProtKB/Swiss-Prot:Q45492" /translation="MLRDLGRRVAIAAILSGIILGGMSISLANMPHSPAGGTVKLNHP *" /label="ykpC CDS" gene complement(1354682..1354816) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /label="ykpC gene" downshifts complement(1354693) /Source="Nicolas_upshifts" /id="D808" /incds=0 /nref=51 /ntot=151 /MaxReadThrough="3.10365" /MaxDrop="5.04142" /score="-2.2377884" /energy="-9.1" /TU="U1192" /idTUdmin="U1193" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1354838..1354856) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1354849) /Source="Nicolas_upshifts" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1354851..1354916) /Source="Nicolas_S_feature" /locus_tag="new_1516508_1516573_c" /HighExp="HiTm, C30, Lbstat, MG-0.2, BC, G135, MG 15, MG 10, MG-0.1, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S524" promotor_-35 complement(1354872..1354877) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1354917..1355924) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16950129, 19643765, 19659933, 21091501, 21636651, 26091431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950129, 19643765, 19659933, 21091501, 21636651, 26091431; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_389330.1" /db_xref="EnsemblGenomes-Gn:BSU14470" /db_xref="EnsemblGenomes-Tr:CAB13320" /db_xref="GOA:P39763" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10987" /db_xref="UniProtKB/Swiss-Prot:P39763" /translation="MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLA IGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVV VCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGG TTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALI EHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGD IVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAI K*" /label="mreBH CDS" gene complement(1354917..1355924) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /label="mreBH gene" upshifts complement(1355970) /Source="Nicolas_upshifts" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1355971..1355979) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1355993..1356001) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1356111..1356120 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-35" upshifts 1356132 /Source="Nicolas_upshifts" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="upshifts" promotor_-10 1356133..1356148 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-10" S_feature 1356135..1356207 /Source="Nicolas_S_feature" /locus_tag="new_1517792_1517864" /HighExp="Lbexp, dia5, LBGexp, dia0, Lbtran, Mt0, Oxctl, Paraq, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S525" CDS 1356208..1356486 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16159768, 17720793, 19767430, 20817675, 20844865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159768, 17720793, 19767430, 20817675, 20844865; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389331.1" /db_xref="EnsemblGenomes-Gn:BSU14480" /db_xref="EnsemblGenomes-Tr:CAB13321" /db_xref="GOA:P39758" /db_xref="InterPro:IPR007159" /db_xref="PDB:2FY9" /db_xref="PDB:2RO3" /db_xref="SubtiList:BG10988" /db_xref="UniProtKB/Swiss-Prot:P39758" /translation="MKSIGVVRKVDELGRIVMPIELRRALDIAIKDSIEFFVDGDKII LKKYKPHGVCLMTGEITSENKEYGNGKITLSPEGAQLLLEEIQAALKE*" /label="abhA CDS" gene 1356208..1356486 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /label="abhA gene" downshifts 1356484 /Source="Nicolas_upshifts" /id="D809" /incds=0 /nref=61 /ntot=238 /MaxReadThrough="4.68201" /MaxDrop="5.62457" /score="7.91393519" /energy="-11" /TU="U1194" /idTUdmin="U1194" /TUdmin="-135" /isTUend="FALSE" /label="downshifts" S_feature complement(1356518..1358147) /Source="Nicolas_S_feature" /locus_tag="new_1518175_1519804_c" /HighExp="S6, S8, S5, LoTm, S4, S7, S3, C30, T5.0H, BT" /AntisenseName="kinC" /AntisenseCor="-0.76370141168998495" /AntisenseRegPval="-51.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S526" S_feature 1356529..1356633 /Source="Nicolas_S_feature" /locus_tag="new_1518186_1518290" /HighExp="Oxctl, Lbexp, LBGexp, H2O2, dia0, Paraq, G180, G150, G135, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S527" downshifts complement(1356541) /Source="Nicolas_upshifts" /id="D810" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.833919999999999" /MaxDrop="3.11258" /score="8.02057524" /energy="-11" /TU="NA" /idTUdmin="U1196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1356615..1356622 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1356634..1356653 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1356635 /Source="Nicolas_upshifts" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="upshifts" CDS 1356676..1357962 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /EC_number="2.7.13.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-responsive histidine kinase regulating cannibalism and biofilm formation" /protein_id="NP_389332.1" /db_xref="EnsemblGenomes-Gn:BSU14490" /db_xref="EnsemblGenomes-Tr:CAB13322" /db_xref="GOA:P39764" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10989" /db_xref="UniProtKB/Swiss-Prot:P39764" /translation="MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAV TLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITY LNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSEL AAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQA ITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMINGDENQLKQVFINIIK NGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGL PICLRILKEHDGELKIESEAGKGSVFQVVLPLKSDS*" /label="kinC CDS" gene 1356676..1357962 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /label="kinC gene" CDS 1357978..1358811 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /EC_number="2.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28537416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative gamma-glutamylcyclotransferase (bacillithiol degradation)" /protein_id="NP_389333.1" /db_xref="EnsemblGenomes-Gn:BSU14500" /db_xref="EnsemblGenomes-Tr:CAB13323" /db_xref="GOA:P39759" /db_xref="InterPro:IPR009288" /db_xref="InterPro:IPR013024" /db_xref="InterPro:IPR036568" /db_xref="PDB:2QIK" /db_xref="SubtiList:BG10990" /db_xref="UniProtKB/Swiss-Prot:P39759" /translation="MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGP TVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKD GCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVL KGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVD VEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPK G*" /label="ykqA CDS" gene 1357978..1358811 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /label="ykqA gene" promotor_-10 complement(1358144..1358162) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1358159) /Source="Nicolas_upshifts" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1358178..1358183) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1358874..1359539 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 22720735, 23963175, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 22720735, 23963175, 28420751; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_389334.1" /db_xref="EnsemblGenomes-Gn:BSU14510" /db_xref="EnsemblGenomes-Tr:CAB13324" /db_xref="GOA:P39760" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG10991" /db_xref="UniProtKB/Swiss-Prot:P39760" /translation="MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKI ASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQN DYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAG NTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVL HTK*" /label="ktrC CDS" gene 1358874..1359539 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /label="ktrC gene" downshifts 1359523 /Source="Nicolas_upshifts" /id="D811" /incds=0 /nref=191 /ntot=256 /MaxReadThrough="3.15176" /MaxDrop="5.50828" /score="4.60161255" /energy="-8.2" /TU="U1195" /idTUdmin="U1195" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1359630..1359636 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1359651..1359670) /Source="Nicolas_upshift_promotors" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1359651..1359670 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1359663 /Source="Nicolas_upshifts" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1359665) /Source="Nicolas_upshifts" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1359694..1361427 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 8550522, 17183219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 8550522, 17183219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine deaminase" /protein_id="NP_389335.2" /db_xref="EnsemblGenomes-Gn:BSU14520" /db_xref="EnsemblGenomes-Tr:CAB13325" /db_xref="GOA:P39761" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11044" /db_xref="UniProtKB/Swiss-Prot:P39761" /translation="MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAIT DGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVT DPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYE EEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVL NDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDD LLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDL ENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSE QQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKG FGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLP IAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLF DVKSFQHISLQ*" /label="adeC CDS" gene 1359694..1361427 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /label="adeC gene" S_feature complement(1360822..1361426) /Source="Nicolas_S_feature" /locus_tag="new_1522479_1523083_c" /HighExp="Etha, C30, C90, dia15, LBGexp, Cold, dia5, S8, G180, S7" /AntisenseName="adeC" /AntisenseCor="-9.8927927273806792E-3" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S528" downshifts 1361416 /Source="Nicolas_upshifts" /id="D812" /incds=0 /nref=51 /ntot=223 /MaxReadThrough="1.93923" /MaxDrop="6.63088" /score="44.3452043" /energy="-19.5" /TU="NA" /idTUdmin="U1197" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1361461..1363128) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease J1" /protein_id="NP_389336.1" /db_xref="EnsemblGenomes-Gn:BSU14530" /db_xref="EnsemblGenomes-Tr:CAB13326" /db_xref="GOA:Q45493" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001587" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="PDB:3ZQ4" /db_xref="SubtiList:BG11813" /db_xref="UniProtKB/Swiss-Prot:Q45493" /translation="MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPE DELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIG LLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIV HTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDI FRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPK NTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPI PGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGE YRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDI GNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELI SNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV*" /label="rnjA CDS" gene complement(1361461..1363128) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /label="rnjA gene" downshifts complement(1361471) /Source="Nicolas_upshifts" /id="D813" /incds=0 /nref=149 /ntot=269 /MaxReadThrough="4.3738" /MaxDrop="8.12983" /score="37.2074215" /energy="-19.5" /TU="U1199" /idTUdmin="U1200" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1363134..1363343) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /function="9.2: DNA-dependent RNA polymerase" /experiment="publication(s) with functional evidences, PMID:18289874, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18289874, 24187087; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega 1 subunit of RNA polymerase" /protein_id="NP_389337.1" /db_xref="EnsemblGenomes-Gn:BSU14540" /db_xref="EnsemblGenomes-Tr:CAB13327" /db_xref="InterPro:IPR009907" /db_xref="SubtiList:BG13335" /db_xref="UniProtKB/Swiss-Prot:O31718" /translation="MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKEKKFNI EFITPVDGAFLEYEQQSENFKVLEL*" /label="rnpZA CDS" gene complement(1363134..1363343) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /label="rnpZA gene" promotor_-10 complement(1363380..1363399) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1363402) /Source="Nicolas_upshifts" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1363404..1363581) /Source="Nicolas_S_feature" /locus_tag="new_1525061_1525238_c" /HighExp="S5, S8, S7, S6, S4, ferm, nit, T5.0H, HiTm, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97062099999999996" /TUshortSig="SigGF" /TUshortPSig="0.828" /TUlongSig="NA" /TUlongPSig="NA" /label="S529" promotor_-35 complement(1363414..1363417) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1363582) /Source="Nicolas_upshifts" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1363584..1363595) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1363609..1363615) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1363654..1363661 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1363675..1363694 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1363691 /Source="Nicolas_upshifts" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1363729..1364502 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389338.1" /db_xref="EnsemblGenomes-Gn:BSU14550" /db_xref="EnsemblGenomes-Tr:CAB13328" /db_xref="GOA:Q45494" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11814" /db_xref="UniProtKB/Swiss-Prot:Q45494" /translation="MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASG RSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVV FMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAA FPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVG TGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK*" /label="ykrA CDS" gene 1363729..1364502 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /label="ykrA gene" downshifts 1364473 /Source="Nicolas_upshifts" /id="D814" /incds=0 /nref=184 /ntot=249 /MaxReadThrough="2.83896" /MaxDrop="6.20802" /score="28.5519453" /energy="-15.4" /TU="U1201" /idTUdmin="U1201" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1364538..1365092) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11429456, 16207374, 23944997, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16207374, 23944997, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-cysteine deformylase (promiscuous)" /protein_id="NP_389339.1" /db_xref="EnsemblGenomes-Gn:BSU14560" /db_xref="EnsemblGenomes-Tr:CAB13329" /db_xref="GOA:Q45495" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11815" /db_xref="UniProtKB/Swiss-Prot:Q45495" /translation="MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNS QNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKS YLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNG VMFYDHIDKENPFKEPENAIAIER*" /label="defB CDS" gene complement(1364538..1365092) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /label="defB gene" downshifts complement(1364549) /Source="Nicolas_upshifts" /id="D815" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="1.87469" /MaxDrop="5.89844" /score="28.3817715" /energy="-15.4" /TU="NA" /idTUdmin="U1202" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1365114..1365133) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1365124) /Source="Nicolas_upshifts" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1365148..1365155) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1365177 /Source="Nicolas_upshifts" /id="D816" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="0.95601" /MaxDrop="4.18336" /score="0.455865843" /energy="-17.1" /TU="NA" /idTUdmin="U1201" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1365201) /Source="Nicolas_upshifts" /id="D817" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.11854" /MaxDrop="8.20445" /score="-8.94821426" /energy="-15.3" /TU="NA" /idTUdmin="U1204" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(1365202..1365360) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin (toxin I motif)" /protein_id="YP_003097725.1" /db_xref="EnsemblGenomes-Gn:BSU14569" /db_xref="EnsemblGenomes-Tr:CAX52616" /db_xref="GOA:C0H409" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H409" /translation="MYGYGYGGGCCSYGGYGYGGCGYGYGRTFALIVVLFILLIIVGA AYLGGGCC*" /label="ykzV CDS" gene complement(1365202..1365360) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /label="ykzV gene" CDS complement(1365267..1365410) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin" /protein_id="YP_009513955.1" /db_xref="EnsemblGenomes-Gn:BSU14568" /db_xref="EnsemblGenomes-Tr:CCQ48596" /db_xref="UniProtKB/TrEMBL:L8E9Z2" /translation="MPTYKGSGVIKRGGYVICMDMVTAEAAAVMVVTDMVAADMATAA PLR*" /label="putative antitoxin CDS" gene complement(1365267..1365410) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /label="gene" promotor_-35 1365356..1365360 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1365361..1365429) /Source="Nicolas_S_feature" /locus_tag="new_1527018_1527086_c" /HighExp="S8, S7, BT, S6, G/S, B36, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S530" promotor_-10 1365370..1365384 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1365397 /Source="Nicolas_upshifts" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1365413..1365432) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1365442) /Source="Nicolas_upshifts" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1365445..1365454) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1365516..1365523 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1365537..1365556 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1365541 /Source="Nicolas_upshifts" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1365574..1366245 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16684363, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389340.2" /db_xref="EnsemblGenomes-Gn:BSU14570" /db_xref="EnsemblGenomes-Tr:CAB13330" /db_xref="GOA:P21884" /db_xref="InterPro:IPR019454" /db_xref="InterPro:IPR036785" /db_xref="SubtiList:BG10206" /db_xref="UniProtKB/Swiss-Prot:P21884" /translation="MKDAIKRRPGIKIGAFCAMALILTGCMGQDPVDSLHHSLEKAAE SEKPFQEEQNTLKELEAKENQLYDSVMKLNMDDYKKIVALSNKALENVSKREEHLKLE NDSMKKSETEFEEAKTSAEHIKEKDIKEKADAAANHMEKRYTSYGTMYKEYKKALELN KKLYMQLKDKDLTRDDLDQQIDKVNASYEKILKYSGEFNEQTEKYNKAREDLYDAAGY RVKKS*" /label="ykyA CDS" gene 1365574..1366245 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /label="ykyA gene" promotor_-35 1365913..1365922 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1365935..1365953 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1365947 /Source="Nicolas_upshifts" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1366192 /Source="Nicolas_upshifts" /id="D818" /incds=0 /nref=96 /ntot=244 /MaxReadThrough="3.9299" /MaxDrop="6.03956" /score="20.6110953" /energy="-9.9" /TU="U1205" /idTUdmin="U1206" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 1366420..1366425 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1366442..1366461 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1366443..1366668 /Source="Nicolas_S_feature" /locus_tag="new_1528100_1528325" /HighExp="nit, MG-0.1, Diami, MG-0.2, ferm, dia5, Lbexp, dia0, Paraq, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S531" upshifts 1366443 /Source="Nicolas_upshifts" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1366447..1366466) /Source="Nicolas_upshift_promotors" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1366463) /Source="Nicolas_upshifts" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1366567..1366575) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1366573) /Source="Nicolas_upshifts" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1366589..1366597) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1366669..1367784 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /EC_number="1.2.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 alpha subunit)" /protein_id="NP_389341.1" /db_xref="EnsemblGenomes-Gn:BSU14580" /db_xref="EnsemblGenomes-Tr:CAB13331" /db_xref="GOA:P21881" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR017596" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10207" /db_xref="UniProtKB/Swiss-Prot:P21881" /translation="MAAKTKKAIVDSKKQFDAIKKQFETFQILNEKGEVVNEAAMPDL TDDQLKELMRRMVFTRVLDQRSISLNRQGRLGFYAPTAGQEASQIATHFALEKEDFVL PGYRDVPQLIWHGLPLYQAFLFSRGHFRGNQMPDDVNALSPQIIIGAQYIQTAGVALG LKKRGKKAVAITYTGDGGASQGDFYEGINFAGAYKAPAIFVVQNNRYAISTPVEKQSA AETIAQKAVAAGIVGVQVDGMDPLAVYAATAEARERAINGEGPTLIETLTFRYGPHTM AGDDPTKYRTKEIENEWEQKDPLVRFRAFLENKGLWSEEEEAKVIEDAKEEIKQAIKK ADAEPKQKVTDLMKIMYEKMPHNLEEQFEIYTQKESK*" /label="pdhA CDS" gene 1366669..1367784 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /label="pdhA gene" CDS 1367788..1368765 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /EC_number="1.2.4.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 9891797, 10735853, 11976308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 9891797, 10735853, 11976308; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 beta subunit)" /protein_id="NP_389342.1" /db_xref="EnsemblGenomes-Gn:BSU14590" /db_xref="EnsemblGenomes-Tr:CAB13332" /db_xref="GOA:P21882" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10208" /db_xref="UniProtKB/Swiss-Prot:P21882" /translation="MAQMTMIQAITDALRTELKNDENVLVFGEDVGVNGGVFRATEGL QKEFGEDRVFDTPLAESGIGGLALGLGLNGFRPVMEIQFFGFVYEVMDSVSGQMARMR YRSGGRWTSPVTIRSPFGGGVHTPELHADSLEGLVAQQPGIKVVIPSTPYDAKGLLIS AIRDNDPVVFLEHMKLYRSFRQEVPEEEYTIELGKADVKREGTDLSIITYGAMVHESL KAADELEKDGISAEVVDLRTVSPLDIDTIIASVEKTGRAIVVQEAQKQAGIAANVVAE INDRAILSLEAPVLRVAAPDTVFPFSQAESVWLPNHKDVLETARKVLEF*" /label="pdhB CDS" gene 1367788..1368765 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /label="pdhB gene" S_feature 1368766..1368879 /Source="Nicolas_S_feature" /locus_tag="new_1530423_1530536" /HighExp="G150, LBGexp, MG-0.1, G180, C30, Diami, Oxctl, G135, ferm, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S532" promotor_-10 complement(1368800..1368819) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1368817) /Source="Nicolas_upshifts" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1368834..1368837) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1368880..1370208 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /EC_number="2.3.1.12" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit)" /protein_id="NP_389343.1" /db_xref="EnsemblGenomes-Gn:BSU14600" /db_xref="EnsemblGenomes-Tr:CAB13333" /db_xref="GOA:P21883" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10209" /db_xref="UniProtKB/Swiss-Prot:P21883" /translation="MAFEFKLPDIGEGIHEGEIVKWFVKPNDEVDEDDVLAEVQNDKA VVEIPSPVKGKVLELKVEEGTVATVGQTIITFDAPGYEDLQFKGSDESDDAKTEAQVQ STAEAGQDVAKEEQAQEPAKATGAGQQDQAEVDPNKRVIAMPSVRKYAREKGVDIRKV TGSGNNGRVVKEDIDSFVNGGAQEAAPQETAAPQETAAKPAAAPAPEGEFPETREKMS GIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGIKLTYLPYVVKA LTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNADRKSVFEISD EINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKA IVRDGEIVAAPVLALSLSFDHRMIDGATAQNALNHIKRLLNDPQLILMEA*" /label="pdhC CDS" gene 1368880..1370208 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /label="pdhC gene" promotor_-35 1369024..1369031 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1369046..1369065 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1369049 /Source="Nicolas_upshifts" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="upshifts" CDS 1370213..1371625 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /EC_number="1.8.1.4" /EC_number="1.2.1.25" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 6815422, 9352926, 9588797, 12682299, 21856851" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 6815422, 9352926, 9588797, 12682299, 21856851; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes" /protein_id="NP_389344.1" /db_xref="EnsemblGenomes-Gn:BSU14610" /db_xref="EnsemblGenomes-Tr:CAB13334" /db_xref="GOA:P21880" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10210" /db_xref="UniProtKB/Swiss-Prot:P21880" /translation="MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLG GVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGG VAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYS ERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQ MSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRR PNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAA EAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSL NETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTL GEITMEAAEVAIGSPIHIVK*" /label="pdhD CDS" gene 1370213..1371625 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /label="pdhD gene" downshifts 1371622 /Source="Nicolas_upshifts" /id="D819" /incds=0 /nref=241 /ntot=268 /MaxReadThrough="1.82289" /MaxDrop="9.27853" /score="33.2247807" /energy="-12.1" /TU="NA" /idTUdmin="U1207" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1371670..1372044) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1936936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1936936; Product type s : structure" /codon_start=1 /transl_table=11 /product="small peptidoglycan-associated lipoprotein" /protein_id="NP_389345.1" /db_xref="EnsemblGenomes-Gn:BSU14620" /db_xref="EnsemblGenomes-Tr:CAB13335" /db_xref="GOA:P39910" /db_xref="SubtiList:BG10211" /db_xref="UniProtKB/Swiss-Prot:P39910" /translation="MRYRAVFPMLIIVFALSGCTLSTINPMKKSRIDNIHHTQILFFS DENQIDQEAPYYDALLDLEKDYPEQIDKMKVYDKKEGWEDEIETVPTLMVVDQRHVVV KIEGCVKKKEDIIKPLQHVLSK*" /label="slp CDS" gene complement(1371670..1372044) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /label="slp gene" downshifts complement(1371718) /Source="Nicolas_upshifts" /id="D820" /incds=0 /nref=26 /ntot=132 /MaxReadThrough="1.54024" /MaxDrop="3.69756" /score="4.23955997" /energy="-12.1" /TU="NA" /idTUdmin="U1212" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(1372075..1372094) /Source="Nicolas_upshift_promotors" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1372085) /Source="Nicolas_upshifts" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1372248..1372253 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-35" promotor_-10 1372269..1372287 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-10" upshifts 1372279 /Source="Nicolas_upshifts" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="upshifts" S_feature 1372283..1372392 /Source="Nicolas_S_feature" /locus_tag="new_1533940_1534049" /HighExp="S4, S5, S7, S6, S8, S3, BT, G/S, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S533" downshifts complement(1372315) /Source="Nicolas_upshifts" /id="D821" /incds=0 /nref=4 /ntot=18 /MaxReadThrough="1.96608" /MaxDrop="3.4036" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1372376..1372383 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1372394 /Source="Nicolas_upshifts" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1372398..1372417 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1372413..1372623 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /product="small regulatory RNA and messenger RNA (argininemetabolism)" /experiment="publication(s) with functional evidences, PMID:16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348; Product type n: RNA" /function="16.3: Control" /label="srrA RNA" gene 1372413..1372623 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /label="srrA gene" CDS 1372463..1372582 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16164558, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 20444087, 27449348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of GapA synthesis" /protein_id="YP_003097726.1" /db_xref="EnsemblGenomes-Gn:BSU14629" /db_xref="EnsemblGenomes-Tr:CAX52617" /db_xref="InterPro:IPR025236" /db_xref="UniProtKB/Swiss-Prot:C0H410" /translation="MGTIVCQDCNEAIHYFEDEKVTTLYGTCCGQCQCPVDEE*" /label="rgpA CDS" gene 1372463..1372582 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /label="rgpA gene" downshifts complement(1372469) /Source="Nicolas_upshifts" /id="D822" /incds=0 /nref=6 /ntot=35 /MaxReadThrough="3.43398" /MaxDrop="4.36472" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts 1372569 /Source="Nicolas_upshifts" /id="D823" /incds=0 /nref=59 /ntot=171 /MaxReadThrough="5.69396" /MaxDrop="7.24152" /score="51.2534618" /energy="-16.8" /TU="U1214" /idTUdmin="U1213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1372614..>1374213 /Source="Nicolas_S_feature" /locus_tag="new_1534271_1535874" /HighExp="M9-stat, M0t90, B60, M40t90, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T0.30H" /AntisenseName="speA" /AntisenseCor="-0.33575411980382203" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.998" /label="S534" CDS complement(1372622..1374094) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /EC_number="4.1.1.19" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 19114526, 19255484, 20876533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 19114526, 19255484, 20876533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine decarboxylase" /protein_id="NP_389346.1" /db_xref="EnsemblGenomes-Gn:BSU14630" /db_xref="EnsemblGenomes-Tr:CAB13336" /db_xref="GOA:P21885" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10212" /db_xref="UniProtKB/Swiss-Prot:P21885" /translation="MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGE NALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVC GPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGAD IAATSVHKLGGSLTQSSILNMREGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRL ATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGL TGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVT HQQTEVLLPEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEI ITEENISYIFKNLDAGLPVQGPEDSTLHMIRVIKEQKAIQ*" /label="speA CDS" gene complement(1372622..1374094) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /label="speA gene" downshifts complement(1372640) /Source="Nicolas_upshifts" /id="D824" /incds=0 /nref=62 /ntot=198 /MaxReadThrough="3.88498" /MaxDrop="6.76978" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(1374095..1374190) /Source="Nicolas_S_feature" /locus_tag="new_1535752_1535847_c" /HighExp="Paraq, G180, LBGexp, Oxctl, G150, G135, C30, H2O2, BMM, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S535" promotor_-10 complement(1374173..1374192) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1374190) /Source="Nicolas_upshifts" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1374197..1374200 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1374207..>1374213) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 1374213..1374214 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs27_019" CDS 1374411..1376351 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16501307" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389354.1" /db_xref="EnsemblGenomes-Gn:BSU14710" /db_xref="EnsemblGenomes-Tr:CAB13344" /db_xref="GOA:O07625" /db_xref="SubtiList:BG13338" /db_xref="UniProtKB/Swiss-Prot:O07625" /translation="MLFVLELFSHYVLHFERYFILSRQSTLLIQWSIVVLAGLYLLVH HPKINRQRTMFLAGVILRIVLLAGVSVELIHQVQSTNFTSAYLREDGKELLPLLHFLL YGYVLLTAFHYMLMPRDHGGKGKFYTFDLAVVSLPIVQMIFSFFSYWKEYPDGMEPIA FVFLFFIITLPIALNVVFFKLYWRTDKILLGLFYTLIIGLLVLLLAPYPNQISKDYGA VMPYTIYLAMAGFLMSYHLFQKSGKVYVRVNKWVTMAVMVFFVLLLNPIYNIGTAAFA VSKPANVHDSFNFVGEHISSEKAEQILKSFFPTDETLYLHDTNMDVHYFYSFESKGYK AEVDEVSQLIRNYEYLQKAHGKKLTNQEYKRKSIAFLERHGRVLHKDHIETKVSQEDG QTVVRIYLKNQLHKKDHADDGAVFYWEKETLMGFSEDPSIYQLDSLLHVHITEQDIHD KVEQMFTALNISKQPYQITDIESDSLLGSMVRVETKVGIVLEFEGESGCLHSLSLPMK KNISMANSRLQHQILSIFDARGSEKKKKSSQGDMVMYTDSSKTYEFVEAQGQLNVYVY SDTPDQSFPYTYRNGTLAYEKVASLYQDVIYKKRMRPIIVQRGDERHYAWLIIIQPFG SNRHDAYVVDGETQEVKSLYES*" /label="ylaA CDS" gene 1374411..1376351 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /label="ylaA gene" CDS 1376341..1376610 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 16501307" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389355.1" /db_xref="EnsemblGenomes-Gn:BSU14720" /db_xref="EnsemblGenomes-Tr:CAB13345" /db_xref="GOA:O07626" /db_xref="SubtiList:BG13339" /db_xref="UniProtKB/Swiss-Prot:O07626" /translation="MNHKEKESVFVDLYDLYKEGELEDESMEWMKQHESLFQKNAEDL KSKTCLKRSPGAEEESQIRYMKVYLSSMYICFILLAIWMTVWFYF*" /label="ylaB CDS" gene 1376341..1376610 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /label="ylaB gene" promotor_-35 1376576..1376580 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1376594..1376613 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1376607 /Source="Nicolas_upshifts" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1376610..1377131 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF-type sigma factor" /protein_id="NP_389356.1" /db_xref="EnsemblGenomes-Gn:BSU14730" /db_xref="EnsemblGenomes-Tr:CAB13346" /db_xref="GOA:O07627" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13340" /db_xref="UniProtKB/Swiss-Prot:O07627" /translation="MKHRDSIEDLYRQYYQEILNYLFRRTHHLETAKDLAQDTFVKAL NGLASFRGHSSIRTWLYTIAHHTFINWYRRDVKYQFTEISKNEGLTQTTYDQPEQYLS RTVKSETLRQELLKLKDQHQSVLILREFQELSYEEIAEILGWSLSKVNTTLHRARLEL KKNMTKSREEERI*" /label="sigP CDS" gene 1376610..1377131 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /label="sigP gene" CDS 1377128..1377421 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-SigP(YlaC) sigma factor" /protein_id="NP_389357.1" /db_xref="EnsemblGenomes-Gn:BSU14740" /db_xref="EnsemblGenomes-Tr:CAB13347" /db_xref="GOA:O07628" /db_xref="InterPro:IPR027383" /db_xref="SubtiList:BG13341" /db_xref="UniProtKB/Swiss-Prot:O07628" /translation="MTCFLVRDLLPLYLEGDCKRETEHVIEEHLKMCSSCRDMYDTMA EPFELESEQAVEEAYLPEEELRFKQRYYGLLIMKAACWFGAAVAMMLIIKLLI*" /label="sigQ CDS" gene 1377128..1377421 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /label="sigQ gene" CDS complement(1377461..1378072) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389358.1" /db_xref="EnsemblGenomes-Gn:BSU14750" /db_xref="EnsemblGenomes-Tr:CAB13348" /db_xref="SubtiList:BG13342" /db_xref="UniProtKB/Swiss-Prot:O07629" /translation="MKKTFVKKAMLTTAAMTSAALLTFGPDAASAKTPVDNTAVQLQH QASTNEDLNTFIDILNQCIYEQDGVYYFDSEKAVELGMTKEEAQVIATLWESTSEFFS IVSQCVYLEDGNYKFDTEKAVELGFTEKEALALEQFFSAVSLKIHILQAAIVLQDDVY SYDKDAALQAGATPLQADVYEKLFSALSQEQLAAIYDMIHPQA*" /label="ylaE CDS" gene complement(1377461..1378072) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /label="ylaE gene" downshifts complement(1377475) /Source="Nicolas_upshifts" /id="D831" /incds=0 /nref=44 /ntot=184 /MaxReadThrough="1.37453" /MaxDrop="4.23106" /score="20.8244305" /energy="-11.7" /TU="NA" /idTUdmin="U1225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1378104..1378123) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1378113) /Source="Nicolas_upshifts" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1378138..1378141) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1378328) /Source="Nicolas_upshifts" /id="D832" /incds=0 /nref=18 /ntot=138 /MaxReadThrough="2.72081" /MaxDrop="5.25382" /score="5.78870736" /energy="-8.3" /TU="NA" /idTUdmin="U1226" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1378345..1378533) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389359.1" /db_xref="EnsemblGenomes-Gn:BSU14760" /db_xref="EnsemblGenomes-Tr:CAB13349" /db_xref="GOA:O07630" /db_xref="InterPro:IPR035211" /db_xref="SubtiList:BG13343" /db_xref="UniProtKB/Swiss-Prot:O07630" /translation="MKKMNWLLLLFAFAAVFSIMLIGVFIAEKSPAGIIASIVLVCAV MGGGFTLKKKMREQGLLD*" /label="ylaF CDS" gene complement(1378345..1378533) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /label="ylaF gene" downshifts complement(1378399) /Source="Nicolas_upshifts" /id="D833" /incds=0 /nref=9 /ntot=204 /MaxReadThrough="4.38484" /MaxDrop="3.2214" /score="5.78870736" /energy="-8.3" /TU="U1226" /idTUdmin="U1226" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1378555..1378574) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1378572) /Source="Nicolas_upshifts" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1378587..1378594) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1378600..1378619 /Source="Nicolas_upshift_promotors" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1378607 /Source="Nicolas_upshifts" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="upshifts" CDS 1378646..1380484 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11683274, 12399512, 9642082, 25135187, 26283392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-associated GTPase" /protein_id="NP_389360.1" /db_xref="EnsemblGenomes-Gn:BSU14770" /db_xref="EnsemblGenomes-Tr:CAB13350" /db_xref="GOA:O07631" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006298" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035651" /db_xref="SubtiList:BG13344" /db_xref="UniProtKB/Swiss-Prot:O07631" /translation="MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERA MDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVD AYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQL EFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYND YVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLV AVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIE ERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIK EIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGL IGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIED RGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMS LEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS*" /label="bipA CDS" gene 1378646..1380484 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /label="bipA gene" CDS 1380541..1380858 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unkown function" /protein_id="NP_389361.1" /db_xref="EnsemblGenomes-Gn:BSU14780" /db_xref="EnsemblGenomes-Tr:CAB13351" /db_xref="GOA:O07632" /db_xref="InterPro:IPR025620" /db_xref="SubtiList:BG13345" /db_xref="UniProtKB/Swiss-Prot:O07632" /translation="MNDVSERLSFFAALYQVDRQPAAGMWLLYGTIFVLAVIVFKLGF AKRLPVLKSAVVYVFLALGCTVLTFLGVFLPVAEGLVVAALILIIYKIRLYQSKKGQS AKS*" /label="ylaH CDS" gene 1380541..1380858 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /label="ylaH gene" downshifts 1380832 /Source="Nicolas_upshifts" /id="D834" /incds=0 /nref=241 /ntot=297 /MaxReadThrough="2.76511" /MaxDrop="7.50514" /score="29.8701447" /energy="-12.5" /TU="NA" /idTUdmin="U1227" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(1380907) /Source="Nicolas_upshifts" /id="D835" /incds=0 /nref=240 /ntot=265 /MaxReadThrough="0.672690000000001" /MaxDrop="7.03405" /score="10.4340016" /energy="-12.5" /TU="NA" /idTUdmin="U1228" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1380914..1381123) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389362.1" /db_xref="EnsemblGenomes-Gn:BSU14790" /db_xref="EnsemblGenomes-Tr:CAB13352" /db_xref="InterPro:IPR019241" /db_xref="SubtiList:BG13346" /db_xref="UniProtKB/Swiss-Prot:O07633" /translation="MMRVKCSICDKIETIDDDTLIAKRLRNRPIHTYMCQECHDRIAK KTEERLKTGKFTFHPGQQKKEKVKK*" /label="ylaI CDS" gene complement(1380914..1381123) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /label="ylaI gene" misc_feature complement(1381137..1381156) /Source="Nicolas_upshift_promotors" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1381152) /Source="Nicolas_upshifts" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1381206..1381835) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_389363.1" /db_xref="EnsemblGenomes-Gn:BSU14800" /db_xref="EnsemblGenomes-Tr:CAB13353" /db_xref="GOA:O07634" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13347" /db_xref="UniProtKB/Swiss-Prot:O07634" /translation="MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVK DTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVET IKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVL PEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND*" /label="ylaJ CDS" gene complement(1381206..1381835) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /label="ylaJ gene" downshifts complement(1381237) /Source="Nicolas_upshifts" /id="D836" /incds=0 /nref=57 /ntot=112 /MaxReadThrough="1.90936" /MaxDrop="5.8475" /score="3.85709048" /energy="-7.2" /TU="NA" /idTUdmin="U1229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1381737..1381755) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1381743) /Source="Nicolas_upshifts" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1381767..1381775) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1381870..1381881) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1381875) /Source="Nicolas_upshifts" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1381887..1381892 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-35" promotor_-35 complement(1381896..1381902) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1381908..1381926 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-10" upshifts 1381908 /Source="Nicolas_upshifts" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="upshifts" S_feature 1381909..1381989 /Source="Nicolas_S_feature" /locus_tag="new_1549384_1549464" /HighExp="S3, S5, S4, S8, S6, S7, LoTm, T5.0H, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S538" CDS 1381990..1383318 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12762842, 17114254; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phosphate starvation inducible protein" /protein_id="NP_389364.1" /db_xref="EnsemblGenomes-Gn:BSU14810" /db_xref="EnsemblGenomes-Tr:CAB13354" /db_xref="GOA:O07635" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG13348" /db_xref="UniProtKB/Swiss-Prot:O07635" /translation="MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYM DEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDN RILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYS GYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGT VLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQ TEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELD AILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGD PEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL*" /label="ylaK CDS" gene 1381990..1383318 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /label="ylaK gene" S_feature complement(1383174..1383321) /Source="Nicolas_S_feature" /locus_tag="new_1550649_1550796_c" /HighExp="M40t90, M0t90, dia15, Lbtran, dia5, Etha, Mt0, Gly, LBGtran, LPhT" /AntisenseName="ylaK" /AntisenseCor="-0.66426410013570203" /AntisenseRegPval="-34.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S539" downshifts complement(1383217) /Source="Nicolas_upshifts" /id="D837" /incds=1 /nref=6 /ntot=67 /MaxReadThrough="3.81309" /MaxDrop="3.44499" /score="3.85709048" /energy="-7.2" /TU="U1232" /idTUdmin="U1232" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 1383319..1383909 /Source="Nicolas_S_feature" /locus_tag="new_1550794_1551384" /HighExp="S3, S4, S6, S5, S8, S7, BT, B36, LoTm, T5.0H" /AntisenseName="ylaL" /AntisenseCor="-0.79954210237955903" /AntisenseRegPval="-60.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S540" CDS complement(1383322..1383807) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389365.1" /db_xref="EnsemblGenomes-Gn:BSU14820" /db_xref="EnsemblGenomes-Tr:CAB13355" /db_xref="GOA:O07636" /db_xref="InterPro:IPR020229" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13349" /db_xref="UniProtKB/Swiss-Prot:O07636" /translation="MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSA GDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNSSATQC VFVTSSGKAAVSLETALNSIVHFSEAGKPIQEGGPVHIYFEDPVHHKQPITDVKEIEI I*" /label="ylaL CDS" gene complement(1383322..1383807) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /label="ylaL gene" promotor_-10 complement(1383819..1383838) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1383847) /Source="Nicolas_upshifts" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1383853..1383860) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1383910..1384839 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:18459799" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18459799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine amidohydrolase; glutaminase" /protein_id="NP_389366.1" /db_xref="EnsemblGenomes-Gn:BSU14830" /db_xref="EnsemblGenomes-Tr:CAB13356" /db_xref="GOA:O07637" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="SubtiList:BG13350" /db_xref="UniProtKB/Swiss-Prot:O07637" /translation="MVCQHNDELEALVKKAKKVTDKGEVASYIPALAKADKHDLSVAI YYSNNVCLSAGDVEKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIK LETVNPSKPLNPMINAGALVVTSLIRGRTVKERLDYLLSFIRRLTNNQEITYCREVAE SEYSTSMINRAMCYYMKQYGIFEDDVEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGR HPETGEQVISKDVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISPYDFG IGIFGPALDEKGNSIAGVKLLEIMSEMYRLSIF*" /label="glsB CDS" gene 1383910..1384839 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /label="glsB gene" misc_feature 1384424..1384443 /Source="Nicolas_upshift_promotors" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1384433 /Source="Nicolas_upshifts" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="upshifts" promotor_-35 1384863..1384866 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1384881..1384900 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1384889 /Source="Nicolas_upshifts" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1384937..1385218 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12682299, 16880555, 17005971,17469204" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389367.1" /db_xref="EnsemblGenomes-Gn:BSU14840" /db_xref="EnsemblGenomes-Tr:CAB13357" /db_xref="InterPro:IPR009983" /db_xref="InterPro:IPR036270" /db_xref="SubtiList:BG13351" /db_xref="UniProtKB/Swiss-Prot:O07638" /translation="MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYE EVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK*" /label="ylaN CDS" gene 1384937..1385218 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /label="ylaN gene" downshifts 1385207 /Source="Nicolas_upshifts" /id="D838" /incds=0 /nref=72 /ntot=227 /MaxReadThrough="5.3857" /MaxDrop="6.58793" /score="2.26145837" /energy="-6.9" /TU="U1234" /idTUdmin="U1231" /TUdmin=328 /isTUend="FALSE" /label="downshifts" promotor_-35 1385281..1385284 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1385297..1385423 /Source="Nicolas_S_feature" /locus_tag="new_1552772_1552898" /HighExp="S1, T5.0H, T4.0H, HiOs, T3.30H, T3.0H, Etha, Heat, T2.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="0.619, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S541" upshifts 1385297 /Source="Nicolas_upshifts" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1385302..1385308 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1385424..1386635 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9622350, 12626683, 15849754, 16850406, 21386816, 27895631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 12626683, 15849754, 16850406, 21386816, 27895631; Product type t : transporter" /codon_start=1 /transl_table=11 /product="cell-division protein; transporter of lipid-linked cell wall precursors" /protein_id="NP_389368.1" /db_xref="EnsemblGenomes-Gn:BSU14850" /db_xref="EnsemblGenomes-Tr:CAB13358" /db_xref="GOA:O07639" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG13352" /db_xref="UniProtKB/Swiss-Prot:O07639" /translation="MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSS NFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGN AQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLI AMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTE GRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFI MAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINL GGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGM KKKQLKKTVYL*" /label="ftsW CDS" gene 1385424..1386635 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /label="ftsW gene" promotor_-35 1386645..1386649 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1386664..1386683 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1386683 /Source="Nicolas_upshifts" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1386710..1390156 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /EC_number="6.4.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6425269, 15134465, 20081037, 20097852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate carboxylase" /protein_id="NP_389369.1" /db_xref="EnsemblGenomes-Gn:BSU14860" /db_xref="EnsemblGenomes-Tr:CAB13359" /db_xref="GOA:Q9KWU4" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR003379" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR005930" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG12660" /db_xref="UniProtKB/Swiss-Prot:Q9KWU4" /translation="MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSY HRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEE EGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQV IGDKQGNVVHLFERDCSVQRRHQKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINA GTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQGHSLHSKKVNIPE QKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPY YDSLLVKLSTWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTS FIDTTPELFNFPKQKDRGTKMLTYIGNVTVNGFPGIGKKEKPAFDKPLGVKVDVDQQP ARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKIANPTA ALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTN YPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDIL DKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHL HTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNV QGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWN EVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVE LFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQEFKEQHNLEISD QDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKL ISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTV IKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGDLLLEIE KA*" /label="pycA CDS" gene 1386710..1390156 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /label="pycA gene" promotor_-10 complement(1389722..1389740) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1389742) /Source="Nicolas_upshifts" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1389756..1389761) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1390136 /Source="Nicolas_upshifts" /id="D839" /incds=0 /nref=20 /ntot=213 /MaxReadThrough="5.5667" /MaxDrop="6.03063" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts 1390181 /Source="Nicolas_upshifts" /id="D840" /incds=0 /nref=2 /ntot=51 /MaxReadThrough="4.21552" /MaxDrop="4.9051" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=44 /isTUend="FALSE" /label="downshifts" downshifts complement(1390213) /Source="Nicolas_upshifts" /id="D841" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="2.24992" /MaxDrop="3.11732" /score="10.1921506" /energy="-11.8" /TU="NA" /idTUdmin="U1238" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 1390225 /Source="Nicolas_upshifts" /id="D842" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="3.6246" /MaxDrop="4.10361" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(1390559..1391479) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /EC_number="1.3.-.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12206660, 15491161, 15849754, 16321940, 16850406, 26592143" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12206660, 15491161, 15849754, 16321940, 16850406, 26592143; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heme-A synthase" /protein_id="NP_389370.1" /db_xref="EnsemblGenomes-Gn:BSU14870" /db_xref="EnsemblGenomes-Tr:CAB13360" /db_xref="GOA:P12946" /db_xref="InterPro:IPR003780" /db_xref="InterPro:IPR023755" /db_xref="SubtiList:BG10213" /db_xref="UniProtKB/Swiss-Prot:P12946" /translation="MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHG RFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFL QALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKK MQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRA AALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFAL AHSFFIACLFGVLCYFLLLIARFRYESRQS*" /label="ctaA CDS" gene complement(1390559..1391479) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /label="ctaA gene" downshifts complement(1390565) /Source="Nicolas_upshifts" /id="D843" /incds=0 /nref=126 /ntot=238 /MaxReadThrough="2.72676" /MaxDrop="5.67271" /score="28.8671863" /energy="-15.3" /TU="U1238" /idTUdmin="U1238" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1391519..1391538) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1391534) /Source="Nicolas_upshifts" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1391552..1391559) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1391614..1391621 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1391635..1391654 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1391636..1391741 /Source="Nicolas_S_feature" /locus_tag="new_1559111_1559216" /HighExp="LBGstat, M0t90, Lbstat, BC, T0.30H, T1.30H, B60, M9-stat, M40t90, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S542" upshifts 1391636 /Source="Nicolas_upshifts" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" S_feature 1391743..1391833 /Source="Nicolas_S_feature" /locus_tag="new_1559218_1559308" /HighExp="LBGstat, M0t90, LPhT, BC, UNK1, BI, Lbexp, LBGtran, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S543" upshifts 1391743 /Source="Nicolas_upshifts" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1391749..1391752 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1391767..1391783 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1391834..1392751 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protoheme IX farnesyltransferase 2" /protein_id="NP_389371.1" /db_xref="EnsemblGenomes-Gn:BSU14880" /db_xref="EnsemblGenomes-Tr:CAB13361" /db_xref="GOA:P24009" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG10214" /db_xref="UniProtKB/Swiss-Prot:P24009" /translation="MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTG MWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVT GKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTV VGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM LPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKN IMKWATQMFVYSLNYMTIYFVAMVVLTLF*" /label="ctaB CDS" gene 1391834..1392751 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /label="ctaB gene" downshifts 1392780 /Source="Nicolas_upshifts" /id="D844" /incds=0 /nref=33 /ntot=75 /MaxReadThrough="8.35391" /MaxDrop="5.6457" /score="0.893081758" /energy="-11.8" /TU="U1239,U1240" /idTUdmin="U1236" /TUdmin=1719 /isTUend="FALSE" /label="downshifts" upshifts 1392799 /Source="Nicolas_upshifts" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1392800..1392805 /Source="Nicolas_upshift_promotors" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1392859..1392864 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1392879..1392897 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1392887..1392990 /Source="Nicolas_S_feature" /locus_tag="new_1560362_1560465" /HighExp="Lbstat, M0t90, M40t90, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, Sig-, SigA, SigA" /TUshortPSig="0.451, 0.407, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S544" upshifts 1392887 /Source="Nicolas_upshifts" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" CDS 1392991..1394061 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 9829923, 9882689, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 9829923, 9882689, 27503613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit II)" /protein_id="NP_389372.1" /db_xref="EnsemblGenomes-Gn:BSU14890" /db_xref="EnsemblGenomes-Tr:CAB13362" /db_xref="GOA:P24011" /db_xref="InterPro:IPR001505" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR014222" /db_xref="InterPro:IPR034236" /db_xref="InterPro:IPR036257" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10215" /db_xref="UniProtKB/Swiss-Prot:P24011" /translation="MVKHWRLILLLALVPLLLSGCGKPFLSTLKPAGEVADKQYDLTV LSTLIMVVVVAVVSVIFFYVIVRFRRSRVGENTIPKQVEGNKFLEITWTVIPILLLII LVIPVVLYTLELADTSPMDKKGRKAEDALVVNVRANLYWWEFEYPDYGIITSQELIVP TDQRVYFNLKASDVKHSFWIPSVGGKLDTNTDNENKFFLTFDSKRSKEAGDMFFGKCA ELCGPSHALMDFKVKTMSAKEFQGWTKEMKNYKSTAESDLAKQGEELFKEKNCLSCHA VEPNDKRAEAARTAPNLATFGERTKVAGVKEANKENVKAWLKDPDSIKPGNKMTGTYP KLSDSETNALYEYLKGLKAESK*" /label="ctaC CDS" gene 1392991..1394061 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /label="ctaC gene" CDS 1394094..1395962 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit I)" /protein_id="NP_389373.2" /db_xref="EnsemblGenomes-Gn:BSU14900" /db_xref="EnsemblGenomes-Tr:CAB13363" /db_xref="GOA:P24010" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014241" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10216" /db_xref="UniProtKB/Swiss-Prot:P24010" /translation="MLNALTEKRTRGSMLWDYLTTVDHKKIAILYLVAGGFFFLVGGI EAMFIRIQLAKPENAFLSAQAYNEVMTMHGTTMIFLAAMPLLFALMNAVVPLQIGARD VSFPFLNALGFWLFFFGGIFLNLSWFLGGAPDAGWTSYASLSLHSKGHGIDFFVLGLQ ISGLGTLIAGINFLATIINMRAPGMTYMRLPLFTWTTFVASALILFAFPPLTVGLALM MLDRLFGTNFFNPELGGNTVIWEHLFWIFGHPEVYILILPAFGIFSEVIPVFARKRLF GYSSMVFAIVLIGFLGFMVWVHHMFTTGLGPIANAIFAVATMAIAIPTGIKIFNWLLT IWGGNVKYTTAMLYAVSFIPSFVLGGVTGVMLAAAAADYQFHDTYFVVAHFHYVIIGG VVFGLLAGVHFWWPKMFGKILHETMGKISFVLFFIGFHLTFFIQHFVGLMGMPRRVYT FLPGQGLETGNLISTIGAFFMAAAVILLLVNVIWTSVKGEYVGADPWHDGRTLEWTVS SPPPEYNFKQLPFVRGLDPLWIEKQAGHKSMTPAEPVDDIHMPNGSILPLIISFGLFV AAFGLLYRSDYAWGLPVIFIGLGITFITMLLRSVIDDHGYHIHKEELPNDDKGVKA*" /label="ctaD CDS" gene 1394094..1395962 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /label="ctaD gene" CDS 1395962..1396585 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit III)" /protein_id="NP_389374.1" /db_xref="EnsemblGenomes-Gn:BSU14910" /db_xref="EnsemblGenomes-Tr:CAB13364" /db_xref="GOA:P24012" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10217" /db_xref="UniProtKB/Swiss-Prot:P24012" /translation="MQVQEKFTAETFPASPEKVTLEGKNKFLGFWLFLGGETVLFASL FATFLALRNSNAGDPPTTEMFDVTLVFIATMLLLTSSLTSVYAMYHMKNFSFGKMQLW LGITILLGAGFLGLEIYEFKHYTHEFGFTITSSALGSAFYTLVGTHGAHVAFGLMWIS TLMIRNAKRGLNLYTAPKFYVASLYWHFIDVVWVFIFTVVYLMGMVG*" /label="ctaE CDS" gene 1395962..1396585 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /label="ctaE gene" CDS 1396588..1396920 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit IV)" /protein_id="NP_389375.1" /db_xref="EnsemblGenomes-Gn:BSU14920" /db_xref="EnsemblGenomes-Tr:CAB13365" /db_xref="GOA:P24013" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014257" /db_xref="SubtiList:BG10218" /db_xref="UniProtKB/Swiss-Prot:P24013" /translation="MVDKKSRGHINSDLEFKKKKHAREMKYQVLSFGLMIGLTIVAFL TVATDGVGSWFTIPFIILLAAIQVIFQLYYFMHMNQKGHEAPALFLYSGVFVAFITVL AFVTIIWW*" /label="ctaF CDS" gene 1396588..1396920 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /label="ctaF gene" CDS 1396947..1397840 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /function="16.10: Respire" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14766920, 15849754, 16305244, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14766920, 15849754, 16305244, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome aa(3) assembly factor" /protein_id="NP_389376.1" /db_xref="EnsemblGenomes-Gn:BSU14930" /db_xref="EnsemblGenomes-Tr:CAB13366" /db_xref="GOA:O34329" /db_xref="InterPro:IPR014108" /db_xref="InterPro:IPR019108" /db_xref="SubtiList:BG12579" /db_xref="UniProtKB/Swiss-Prot:O34329" /translation="MNQLEIFGFRAMWSPYLFCILLGITALYLYFYRRMSSKPNRITG KEMVCFLSAMLFLYAAEGSPVDLLGHIMFSAHMVQMAVLYLVVPPLLIAGIPAWLWEK IIFRPSIKPVFSFFTTPLIALLLFNGIFSLYHVPLIFDTVKTDPFYHTLITWLIFVLA FFMWWPLVHKVERLRQLSGLMKLGYIMADGMLLTPACALIMFSGAPLYATYTDPALWA EAMRLCVPADMMGQVPLTGPEMLNTLPLLEDQQLGAVMMKIIQEIVYGTFLAVIFFQW VKKEREKDGQEEPPYIQQTIS*" /label="ctaG CDS" gene 1396947..1397840 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /label="ctaG gene" downshifts 1397815 /Source="Nicolas_upshifts" /id="D845" /incds=0 /nref=121 /ntot=229 /MaxReadThrough="1.94099" /MaxDrop="5.91271" /score="4.35633365" /energy="-13.3" /TU="NA" /idTUdmin="U1239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1397872..1398234) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389377.1" /db_xref="EnsemblGenomes-Gn:BSU14940" /db_xref="EnsemblGenomes-Tr:CAB13367" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG13353" /db_xref="UniProtKB/Swiss-Prot:O34743" /translation="MLKFTESGLEGVKAELSWLDDLMESKGLIRAGQWDYERVTYDKK FSTIEGTFYLRIQGIAAEGDVGSGRAVIQLMSPLLGKHYYPHGVEYGETEEFPVQVVT KSKALIQDIANMLKTVQM*" /label="ylbA CDS" gene complement(1397872..1398234) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /label="ylbA gene" downshifts complement(1397891) /Source="Nicolas_upshifts" /id="D846" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="1.00586" /MaxDrop="6.68145" /score="-3.42191479" /energy="-11.2" /TU="NA" /idTUdmin="U1244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1398227..1398231 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1398240..1398253 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1398258..1398277) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1398262..1398373 /Source="Nicolas_S_feature" /locus_tag="new_1565737_1565848" /HighExp="S7, S8, S4, S3, S6, S5, T5.0H, T4.0H, BC, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.368" /TUlongSig="NA" /TUlongPSig="NA" /label="S545" upshifts 1398262 /Source="Nicolas_upshifts" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1398270) /Source="Nicolas_upshifts" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1398292..1398299) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1398374..1398820 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389378.2" /db_xref="EnsemblGenomes-Gn:BSU14950" /db_xref="EnsemblGenomes-Tr:CAB13368" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG13354" /db_xref="UniProtKB/Swiss-Prot:O34682" /translation="MTKIKDLMTADLQYCTVLDNVYEAAVKMKDANVGAIPVVDEDGE TLVGIVTDRDLVLRGIAIKKPNSQKITDAMTEKPVSVEEDASVDEVLHLMASHQLRRI PVTKNKKLTGIVTLGDLSLSEQTNERAGSALSDISEGDNREEGFFH*" /label="ylbB CDS" gene 1398374..1398820 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /label="ylbB gene" promotor_-35 1398406..1398413 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1398425..1398444 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1398430 /Source="Nicolas_upshifts" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1398829..1398836 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1398850..1398869 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1398861 /Source="Nicolas_upshifts" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" CDS 1398904..1399944 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389379.1" /db_xref="EnsemblGenomes-Gn:BSU14960" /db_xref="EnsemblGenomes-Tr:CAB13369" /db_xref="GOA:O34586" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR029410" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13355" /db_xref="UniProtKB/Swiss-Prot:O34586" /translation="MKNILRAMVILLIICGTYVLFIQYGSVPEKKSNDSEPQVSNEEA QSGKRIHMPTSGLLSFMGKHADEVTKKLGEPERIDPSAYDYDWWVYNQGKDQYIQIGV LNNKVVTLFASGNDINAKPFKIGESTGEVFKTTQVAPFVNVEYKGNSYRFEFSEEDIN TRPTVKVGKMYVQLYMDKFEGKLSSIRAFDAQTFVKQRPYEVVYRGELIKPKAVSDEK WKKIQTTSEKQILDLTNVIRVKHGLAKLEWDQPTAEVAFGHSEDMKENNYFSHVSKKY GSLKDRLEEGHVDFQQAGENIAYNYVDGPAAVEGWLNSEGHRKALLNSDYTHLGVGVD RKYYTQNFIKRW*" /label="ylbC CDS" gene 1398904..1399944 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /label="ylbC gene" promotor_-10 complement(1399867..1399885) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1399872) /Source="Nicolas_upshifts" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1399901..1399906) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1399924 /Source="Nicolas_upshifts" /id="D847" /incds=0 /nref=84 /ntot=252 /MaxReadThrough="1.59604" /MaxDrop="4.17709" /score="-1.16631837" /energy="-8.1" /TU="NA" /idTUdmin="U1243" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 1400108..1400117 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1400131..1400150 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1400145 /Source="Nicolas_upshifts" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="upshifts" CDS 1400176..1400574 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19775244, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related protein (coat)" /protein_id="NP_389380.1" /db_xref="EnsemblGenomes-Gn:BSU14970" /db_xref="EnsemblGenomes-Tr:CAB13370" /db_xref="InterPro:IPR025953" /db_xref="SubtiList:BG13356" /db_xref="UniProtKB/Swiss-Prot:O34880" /translation="MANQHANHSINDFKQFVKKHPKLIKEVRKEQRSWQDVYENWVLF GESDPIWDPYREPEEASEAVPETPQKNDFVSKMVTAVKKMDVNQMNEQINKMSQSISS LQSLLNTFSGSGQKHSQPGSGQHPFSFRKD*" /label="ylbD CDS" gene 1400176..1400574 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /label="ylbD gene" downshifts complement(1400180) /Source="Nicolas_upshifts" /id="D848" /incds=0 /nref=2 /ntot=11 /MaxReadThrough="2.37349" /MaxDrop="4.0378" /score="40.2648817" /energy="-14.3" /TU="NA" /idTUdmin="U1247" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS 1400590..1400829 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389381.1" /db_xref="EnsemblGenomes-Gn:BSU14980" /db_xref="EnsemblGenomes-Tr:CAB13371" /db_xref="InterPro:IPR025613" /db_xref="SubtiList:BG13357" /db_xref="UniProtKB/Swiss-Prot:O34958" /translation="MRKEVQEYILANEERKRFIREQPIWYRRLSRKPDDLSSFQLEMM NFYEKTIPHRVNQFTNGIQMAQMMMQMFQAMRTKD*" /label="ylbE CDS" gene 1400590..1400829 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /label="ylbE gene" downshifts 1400808 /Source="Nicolas_upshifts" /id="D849" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="2.09257" /MaxDrop="4.65792" /score="-7.8200921" /energy="-5.1" /TU="NA" /idTUdmin="U1248" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1400896..1400903 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1400914..1400933 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1400919 /Source="Nicolas_upshifts" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1400945..1401394 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex controlling RNase Y (RicAFTcomplex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389382.1" /db_xref="EnsemblGenomes-Gn:BSU14990" /db_xref="EnsemblGenomes-Tr:CAB13372" /db_xref="GOA:O34412" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="SubtiList:BG13358" /db_xref="UniProtKB/Swiss-Prot:O34412" /translation="MYATMESVRLQSEAQQLAEMILQSETAENYRNCYKRLQEDEEAG RIIRSFIKIKEQYEDVQRFGKYHPDYREISRKMREIKRELDLNDKVADFKRAENELQS ILDEVSVEIGTAVSEHVKVPTGNPYFDGLSSCGGGCGSGGSCGCKVS*" /label="ricF CDS" gene 1400945..1401394 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /label="ricF gene" downshifts 1401380 /Source="Nicolas_upshifts" /id="D850" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="5.95111" /MaxDrop="2.83" /score="-4.2014677" /energy="-11.5" /TU="U1249" /idTUdmin="U1248" /TUdmin=572 /isTUend="FALSE" /label="downshifts" CDS 1401449..1401721 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10712692, 21532344, 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389383.1" /db_xref="EnsemblGenomes-Gn:BSU15000" /db_xref="EnsemblGenomes-Tr:CAB13373" /db_xref="GOA:O34658" /db_xref="InterPro:IPR016979" /db_xref="SubtiList:BG13359" /db_xref="UniProtKB/Swiss-Prot:O34658" /translation="MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMD QIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI*" /label="ylbG CDS" gene 1401449..1401721 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /label="ylbG gene" S_feature complement(1401526..1401749) /Source="Nicolas_S_feature" /locus_tag="new_1569001_1569224_c" /HighExp="S8, S7, S4, S5, S6, S3, C30, BT, G135, C90" /AntisenseName="ylbG" /AntisenseCor="-0.668594452827031" /AntisenseRegPval="-35.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S546" misc_RNA 1401724..1401844 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /product="sporulation-specific regulatory RNA" /experiment="publication(s) with functional evidences, PMID:21532344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21532344; Product type n: RNA" /function="15.7: Sporulation and germination" /label="csfG RNA" gene 1401724..1401844 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /label="csfG gene" S_feature complement(1401751..1401874) /Source="Nicolas_S_feature" /locus_tag="new_1569226_1569349_c" /HighExp="S3, S8, S7, G/S, S4, S5, Pyr, S6, B36, BT" /AntisenseName="NA" /AntisenseCor="-0.69279578575099399" /AntisenseRegPval="-39.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S547" downshifts complement(1401794) /Source="Nicolas_upshifts" /id="D851" /incds=0 /nref=61 /ntot=131 /MaxReadThrough="3.9368" /MaxDrop="7.78892" /score="40.2648817" /energy="-14.3" /TU="U1250" /idTUdmin="U1250" /TUdmin="-228" /isTUend="FALSE" /label="downshifts" S_feature 1401845..1401950 /Source="Nicolas_S_feature" /locus_tag="new_1569320_1569425" /HighExp="H2O2, Paraq, Oxctl, G180, G135, G150, Cold, C30, Diami, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S548" promotor_-10 complement(1401875..1401887) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1401882) /Source="Nicolas_upshifts" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1401902..1401908) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1401931..1401935 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-35" promotor_-10 1401951..1401970 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-10" S_feature 1401952..1402043 /Source="Nicolas_S_feature" /locus_tag="new_1569427_1569518" /HighExp="H2O2, G135, Oxctl, Paraq, G180, dia0, G150, Lbexp, LBGexp, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S549" upshifts 1401952 /Source="Nicolas_upshifts" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="upshifts" CDS 1402044..1402598 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /EC_number="2.1.1.171" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 17389639, 22535590, 22649054; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m2G966 methyltransferase" /protein_id="NP_389384.2" /db_xref="EnsemblGenomes-Gn:BSU15010" /db_xref="EnsemblGenomes-Tr:CAB13374" /db_xref="GOA:O34331" /db_xref="InterPro:IPR004398" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13360" /db_xref="UniProtKB/Swiss-Prot:O34331" /translation="MRVISGSKKGRSLKAVAGTSTRPTTDKVKESIFNMIGPYFDGGR GLDLFAGSGGLGIEALSRGFEHCIFVDRDFKAIQTVKSNLKTLELTKHAQVYRNDAER ALHAAAKRETGFRGIFLDPPYKEQKLKALLTLIDEYQMLEEDGFIVAEHDREVELPET VGDLVMTRKETYGLTGVAIYKKRG*" /label="rsmD CDS" gene 1402044..1402598 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /label="rsmD gene" CDS 1402603..1403088 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /EC_number="2.7.7.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10480925, 10939241, 16014871, 21912874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphopantetheine adenylyltransferase" /protein_id="NP_389385.1" /db_xref="EnsemblGenomes-Gn:BSU15020" /db_xref="EnsemblGenomes-Tr:CAB13375" /db_xref="GOA:O34797" /db_xref="InterPro:IPR001980" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="PDB:1O6B" /db_xref="SubtiList:BG13361" /db_xref="UniProtKB/Swiss-Prot:O34797" /translation="MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKP LFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQG TSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQ G*" /label="coaD CDS" gene 1402603..1403088 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /label="coaD gene" downshifts 1403055 /Source="Nicolas_upshifts" /id="D852" /incds=0 /nref=26 /ntot=196 /MaxReadThrough="3.45558" /MaxDrop="3.85134" /score="13.7782945" /energy="-7.8" /TU="U1249,U1251" /idTUdmin="U1251" /TUdmin="-1296" /isTUend="FALSE" /label="downshifts" CDS complement(1403099..1404325) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15849754, 16850406, 28945739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15849754, 16850406, 28945739; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipicolinic acid transporter (to the spore)" /protein_id="NP_389386.1" /db_xref="EnsemblGenomes-Gn:BSU15030" /db_xref="EnsemblGenomes-Tr:CAB13376" /db_xref="GOA:O34765" /db_xref="InterPro:IPR011642" /db_xref="InterPro:IPR014226" /db_xref="SubtiList:BG13362" /db_xref="UniProtKB/Swiss-Prot:O34765" /translation="MNLSKINTLLIASFFLFLTATVISHPQASFEASKTGLSMWWEVV FPSLLPFFILSELLIGFGIVRFVGVLLEPFMRPIFRVPGVGGFVLAMGMASGNPAGAK LTARLRQENQISRVEAERLASFTNSSNPLFIFGAVAVGFFQNASLGILLASAHYLGNL AVGLTMRSYGRKEEQHLRRKKTIPFPSVKDALHALHTARLAEKRPLGKILGDAVTSSV QTLLMVGGFIILFSVFNRLLSVVQLTDVLSVFTKGALTLFQLPTQLDIPLLSGMFEIT LGSKLVSETDVSLLQKAIIVSFILGFSGFSVQAQVAGILSETDIRFKPFFIARLLQGV YAAVFVMLLWKPLYTAWHDPYQYVFKSLNSSDMSTAFINGWNLLVQIGPAVTLCALFT YIIIFSYRLTNGTKKG*" /label="spoVV CDS" gene complement(1403099..1404325) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /label="spoVV gene" S_feature 1403100..1404374 /Source="Nicolas_S_feature" /locus_tag="new_1570575_1571849" /HighExp="H2O2, G135, Paraq, G150, G180, Oxctl, LBGexp, dia0, dia15, Mt0" /AntisenseName="ylbJ" /AntisenseCor="-0.54237424349391605" /AntisenseRegPval="-21.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S550" S_feature complement(1404326..1404427) /Source="Nicolas_S_feature" /locus_tag="new_1571801_1571902_c" /HighExp="LoTm, S3, S4, S5, T5.0H, M9-stat, T4.0H, S6, BT, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S551" promotor_-35 1404349..1404356 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1404368..1404387 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1404376..1404505 /Source="Nicolas_S_feature" /locus_tag="new_1571851_1571980" /HighExp="Etha, dia15, dia5, Diami, H2O2, Lbtran, LBGtran, Paraq, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S552" upshifts 1404376 /Source="Nicolas_upshifts" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1404422..1404440) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1404437) /Source="Nicolas_upshifts" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1404457..1404462) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1404506..1405288 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389387.1" /db_xref="EnsemblGenomes-Gn:BSU15040" /db_xref="EnsemblGenomes-Tr:CAB13377" /db_xref="GOA:O34731" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG13363" /db_xref="UniProtKB/Swiss-Prot:O34731" /translation="MAKPKIGLALGSGGARGLAHLGVLSSLHKHQIEVDMIAGSSMGA LVGSFYAAGHDVATMKKVAKAFKRRLYADYTVPKLGFLKGDRVRQLVHAYTFGKPIEE LQIPLGIVACDLQTGEKIVFRKGSVSDAVRASISIPGIFIPQRLDGRLLVDGAVVDRI PVSVVKDMGADIIIASDVSRVRKTETAVHIFDVIMQSMDILQNELVRHQTIAADIMIR PSLETYSSSSFANIEEMISAGEEATNRMISKIRKEIENWEGS*" /label="ylbK CDS" gene 1404506..1405288 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /label="ylbK gene" promotor_-35 1405068..1405074 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1405088..1405099 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1405099 /Source="Nicolas_upshifts" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1405290..1406315 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradative enzyme" /protein_id="NP_389388.2" /db_xref="EnsemblGenomes-Gn:BSU15050" /db_xref="EnsemblGenomes-Tr:CAB13378" /db_xref="GOA:O34470" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR036034" /db_xref="PDB:2KJP" /db_xref="SubtiList:BG13364" /db_xref="UniProtKB/Swiss-Prot:O34470" /translation="MLRKKHFSWMLVILILIAVLSFIKLPYYITKPGEATELASLIKV EGGYPEKGSLSLMTVKVGPANPFTYVWAKMHPYYEIVPDESIKEEGESDKEYMKRQLQ MMKSSQENAVIAAYQKAGKKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQ SAEKLIDYISSKKAGDKVTLKIEREEKEKRVTLTLKQFPDEPDRAGIGVSLYTDRNVK VEPDIDFEIENIGGPSAGLMMSLEIYNQLTKPDETKGYDIAGTGTIDVDGKVGPIGGI DQKVVAADKAGKDIFFAPNQNGASNSDYKNAVKTAKDIDSNMKIVPVDTMQDAIDYLN KLKAKST*" /label="ylbL CDS" gene 1405290..1406315 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /label="ylbL gene" downshifts 1406199 /Source="Nicolas_upshifts" /id="D853" /incds=1 /nref=59 /ntot=235 /MaxReadThrough="2.38639" /MaxDrop="3.52503" /score="19.0874959" /energy="-11.5" /TU="NA" /idTUdmin="U1249" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1406332..1407579) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 19215769; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative component of the degradosome" /protein_id="NP_389389.1" /db_xref="EnsemblGenomes-Gn:BSU15060" /db_xref="EnsemblGenomes-Tr:CAB13379" /db_xref="InterPro:IPR008513" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13365" /db_xref="UniProtKB/Swiss-Prot:O34513" /translation="MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQR GEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGS ENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSK PNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQN LEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGL EHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKKQDMQKLLDNDKAPY IRLLGMTKKGQAYLSEKKKALSVPLVSKLSSFSHPALDLDVKASRIYSLPIEEPLRTE FDLQEYGHAPIRYDEDEQHFLNV*" /label="ylbM CDS" gene complement(1406332..1407579) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /label="ylbM gene" downshifts complement(1406359) /Source="Nicolas_upshifts" /id="D854" /incds=0 /nref=8 /ntot=182 /MaxReadThrough="1.58661" /MaxDrop="3.70777" /score="4.49214865" /energy="-11.5" /TU="NA" /idTUdmin="U1257" /TUdmin=775 /isTUend="FALSE" /label="downshifts" promotor_-35 1407496..1407502 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-35" promotor_-10 1407516..1407527 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-10" upshifts 1407520 /Source="Nicolas_upshifts" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="upshifts" CDS complement(1407576..1407761) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein,of unknown function" /protein_id="YP_003097727.1" /db_xref="EnsemblGenomes-Gn:BSU15069" /db_xref="EnsemblGenomes-Tr:CAX52618" /db_xref="UniProtKB/Swiss-Prot:C0H411" /translation="MIIAFKIVFVNIFSLQHNAAIEVSLTAEYAMHTLKTKIRRKSFH LQMYHTFLNIARKAEKI*" /label="ylzH CDS" gene complement(1407576..1407761) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /label="ylzH gene" promotor_-35 1407594..1407598 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-35" promotor_-10 1407614..1407633 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-10" S_feature 1407623..1407758 /Source="Nicolas_S_feature" /locus_tag="new_1575098_1575233" /HighExp="Cold, LoTm, Diami, Paraq, H2O2, Oxctl, G180, dia5, G135, LBGexp" /AntisenseName="ylzH" /AntisenseCor="-9.1134498265910996E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S553" upshifts 1407623 /Source="Nicolas_upshifts" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="upshifts" promotor_-10 complement(1407652..1407671) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1407662) /Source="Nicolas_upshifts" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1407685..1407692) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1407729..1407736 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1407750..1407769 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1407760 /Source="Nicolas_upshifts" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1407789..1408307 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11700356, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389390.1" /db_xref="EnsemblGenomes-Gn:BSU15070" /db_xref="EnsemblGenomes-Tr:CAB13380" /db_xref="InterPro:IPR003772" /db_xref="SubtiList:BG13366" /db_xref="UniProtKB/Swiss-Prot:O34445" /translation="MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKG RADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIV EDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLA ALEKLLKQDDES*" /label="ylbN CDS" gene 1407789..1408307 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /label="ylbN gene" CDS 1408329..1408508 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L32" /protein_id="NP_389391.1" /db_xref="EnsemblGenomes-Gn:BSU15080" /db_xref="EnsemblGenomes-Tr:CAB13381" /db_xref="GOA:O34687" /db_xref="InterPro:IPR002677" /db_xref="InterPro:IPR011332" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12668" /db_xref="UniProtKB/Swiss-Prot:O34687" /translation="MAVPFRRTSKMKKRLRRTHFKLNVPGMTECPSCGEMKLSHRVCK ACGSYNGKDINVKSN*" /label="rpmF CDS" gene 1408329..1408508 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /label="rpmF gene" downshifts 1408488 /Source="Nicolas_upshifts" /id="D855" /incds=0 /nref=232 /ntot=266 /MaxReadThrough="5.64002" /MaxDrop="7.70407" /score="53.0065581" /energy="-17.1" /TU="U1258" /idTUdmin="U1256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1408531) /Source="Nicolas_upshifts" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1408535..1408538) /Source="Nicolas_upshift_promotors" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1408589..1408594 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1408610..1408628 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1408611 /Source="Nicolas_upshifts" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1408654..1409235 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15621419, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15621419, 20435725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="DNA-binding regulator" /protein_id="NP_389392.1" /db_xref="EnsemblGenomes-Gn:BSU15090" /db_xref="EnsemblGenomes-Tr:CAB13382" /db_xref="GOA:O34549" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017930" /db_xref="SubtiList:BG13367" /db_xref="UniProtKB/Swiss-Prot:O34549" /translation="MTITRQDAWTQDEDLLLAEVVLRHIREGGTQLSAFEEVGRALTR TAAACGFRWNSYVRKQYQSGIELAKKQRKELRKQIGVHSVNMPNSMKQTASASSEGKR DLSIQDVIQFLEQFKETPSAQEFQLEREKLKEQIQSLQKELEDLRSENQTLRNQLEMT EEDYKALIDIMDRARKMVVSKEDGRMKKAAQET*" /label="gerR CDS" gene 1408654..1409235 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /label="gerR gene" downshifts 1409236 /Source="Nicolas_upshifts" /id="D856" /incds=0 /nref=56 /ntot=139 /MaxReadThrough="2.70626" /MaxDrop="5.6861" /score="-7.71867756" /energy="-12.8" /TU="U1260" /idTUdmin="U1258" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1409292..1409774) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389393.2" /db_xref="EnsemblGenomes-Gn:BSU15100" /db_xref="EnsemblGenomes-Tr:CAB13383" /db_xref="GOA:O34468" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017274" /db_xref="PDB:2PR1" /db_xref="SubtiList:BG13368" /db_xref="UniProtKB/Swiss-Prot:O34468" /translation="MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDST SPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYLELWKLEVLPGYQNRGYGRALVE FAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDMARDKGENPLIWHPDMDREMTPGESA *" /label="ylbP CDS" gene complement(1409292..1409774) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /label="ylbP gene" downshifts complement(1409311) /Source="Nicolas_upshifts" /id="D857" /incds=0 /nref=90 /ntot=231 /MaxReadThrough="3.90092" /MaxDrop="6.59996" /score="14.5482917" /energy="-14.5" /TU="U1261" /idTUdmin="U1261" /TUdmin="-615" /isTUend="FALSE" /label="downshifts" downshifts 1409764 /Source="Nicolas_upshifts" /id="D858" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.3013" /MaxDrop="4.42908" /score="-7.71867756" /energy="-12.8" /TU="NA" /idTUdmin="U1260" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1409797..1409816) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1409816) /Source="Nicolas_upshifts" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1409830..1409837) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1409874..1409880 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-35" promotor_-10 1409892..1409911 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-10" upshifts 1409894 /Source="Nicolas_upshifts" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="upshifts" CDS 1409934..1410830 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1844812, 10736170, 23894131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1844812, 10736170, 23894131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate 2-reductase" /protein_id="NP_389394.1" /db_xref="EnsemblGenomes-Gn:BSU15110" /db_xref="EnsemblGenomes-Tr:CAB13384" /db_xref="GOA:O34661" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="PDB:3EGO" /db_xref="SubtiList:BG13369" /db_xref="UniProtKB/Swiss-Prot:O34661" /translation="MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIR LYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGH IHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEAC RILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLD AVHLEFLYGSIKALERNTNKVF*" /label="panE CDS" gene 1409934..1410830 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /label="panE gene" CDS 1410901..1412520 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /EC_number="6.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16169927, 19578333, 20308541, 20799687, 25496067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16169927, 19578333, 20308541, 20799687, 25496067; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate glucosamine cysteine ligase" /protein_id="NP_389395.2" /db_xref="EnsemblGenomes-Gn:BSU15120" /db_xref="EnsemblGenomes-Tr:CAB13385" /db_xref="GOA:P55342" /db_xref="InterPro:IPR011199" /db_xref="PDB:4WBD" /db_xref="SubtiList:BG11424" /db_xref="UniProtKB/Swiss-Prot:P55342" /translation="MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLE DLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYT IHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSY WKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLI ADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIE SGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTR PLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLA ERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQS LEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNI MYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL*" /label="bshC CDS" gene 1410901..1412520 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /label="bshC gene" downshifts 1412492 /Source="Nicolas_upshifts" /id="D859" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="3.87099" /MaxDrop="3.76832" /score="34.9463932" /energy="-8.3" /TU="U1262" /idTUdmin="U1262" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 1412554..1412557 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1412572..1412645 /Source="Nicolas_S_feature" /locus_tag="new_1580047_1580120" /HighExp="M9-stat, T5.0H, T3.0H, Lbstat, Lbtran, T2.30H, T1.30H, M0t90, T1.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="SigA" /TUlongPSig=1 /label="S554" promotor_-10 1412572..1412591 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1412572 /Source="Nicolas_upshifts" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1412629) /Source="Nicolas_upshifts" /id="D860" /incds=0 /nref=17 /ntot=137 /MaxReadThrough="3.30554" /MaxDrop="4.47473" /score="-9.92306593" /energy="-12" /TU="NA" /idTUdmin="U1264" /TUdmin=1149 /isTUend="FALSE" /label="downshifts" CDS 1412646..1413077 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /function="16.13: Shape" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10572301, 15939023, 16511046, 24659771, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of RsmH and transcriptional regulator" /protein_id="NP_389396.1" /db_xref="EnsemblGenomes-Gn:BSU15130" /db_xref="EnsemblGenomes-Tr:CAB13386" /db_xref="GOA:P55343" /db_xref="InterPro:IPR003444" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR020603" /db_xref="InterPro:IPR035642" /db_xref="InterPro:IPR035644" /db_xref="SubtiList:BG11425" /db_xref="UniProtKB/Swiss-Prot:P55343" /translation="MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYP MHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKE CVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI*" /label="mraZ CDS" gene 1412646..1413077 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /label="mraZ gene" CDS 1413147..1414082 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /EC_number="2.1.1.199" /function="16.6: Maintain" /function="16.13: Shape" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9294438, 9721276, 10572301, 16849811, 19965768, 20924196, 22561317, 27711192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m4C1402 methyltransferase" /protein_id="NP_389397.1" /db_xref="EnsemblGenomes-Gn:BSU15140" /db_xref="EnsemblGenomes-Tr:CAB13387" /db_xref="GOA:Q07876" /db_xref="InterPro:IPR002903" /db_xref="InterPro:IPR023397" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10219" /db_xref="UniProtKB/Swiss-Prot:Q07876" /translation="MFQHKTVLLRETVDGLNIKPDGTYVDCTLGGAGHSTYLLQQLSE KGRLIAFDQDDTALQHAKEVLSDYKGQLILIKSNFRYLKEYLNEQGVTEVDGILFDLG VSSPQLDTPERGFSYHHDAPLDMRMDQSATLSAKEVVNEWRYEDLVRIFFKYGEEKFS KQIARKIEEARMKSPIQTTGQLVDLIKDAIPAPARRSGGHPAKRVFQAIRIAVNDELR VFEEALEQAIEVLKPGGRVSVITFHSLEDRICKTTFKEKSSLPELPPGLPVIPEEFEP ELKLITRKPITASQEELEENNRARSAKLRIAEKRK*" /label="rsmH CDS" gene 1413147..1414082 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /label="rsmH gene" S_feature complement(1413749..1415201) /Source="Nicolas_S_feature" /locus_tag="new_1581224_1582676_c" /HighExp="Salt, Sw, B60, Etha, M9-stat, Gly, C30, LPhT, BC, B36" /AntisenseName="ftsL" /AntisenseCor="-0.195961042435877" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S555" CDS 1414122..1414475 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein" /protein_id="NP_389398.1" /db_xref="EnsemblGenomes-Gn:BSU15150" /db_xref="EnsemblGenomes-Tr:CAB13388" /db_xref="GOA:Q07867" /db_xref="InterPro:IPR011922" /db_xref="SubtiList:BG10220" /db_xref="UniProtKB/Swiss-Prot:Q07867" /translation="MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAA VLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKK NGLNLKDKKVKNIQE*" /label="ftsL CDS" gene 1414122..1414475 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /label="ftsL gene" CDS 1414472..1416622 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8636036, 10411726, 12682299, 14731276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2B" /protein_id="NP_389399.2" /db_xref="EnsemblGenomes-Gn:BSU15160" /db_xref="EnsemblGenomes-Tr:CAB13389" /db_xref="GOA:Q07868" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10221" /db_xref="UniProtKB/Swiss-Prot:Q07868" /translation="MIQMPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANG EVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQH VVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGI SFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESD KSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPK TGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKY KSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKF NFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKP YVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGF DVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSD PVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLT PIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIH IEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD*" /label="pbpB CDS" gene 1414472..1416622 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /label="pbpB gene" promotor_-10 complement(1415182..1415200) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1415201) /Source="Nicolas_upshifts" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1415215..1415221) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1416605 /Source="Nicolas_upshifts" /id="D861" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="1.141" /MaxDrop="6.28059" /score="3.41058446" /energy="-7.4" /TU="NA" /idTUdmin="U1263" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1416677..1416682 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-35" promotor_-10 1416698..1416716 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-10" upshifts 1416698 /Source="Nicolas_upshifts" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="upshifts" CDS 1416739..1418679 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8244929, 8289242, 9006059, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8244929, 8289242, 9006059, 28383125; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transpeptidase penicillin-binding protein" /protein_id="NP_389400.2" /db_xref="EnsemblGenomes-Gn:BSU15170" /db_xref="EnsemblGenomes-Tr:CAB13390" /db_xref="GOA:Q03524" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR011927" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10222" /db_xref="UniProtKB/Swiss-Prot:Q03524" /translation="MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSL AKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNM SEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLS HVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDM KLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVD PSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWK RGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGIL FPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTV KKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKY LENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVK PRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGT KVKEGSKIRVYLTEEDEKEAAD*" /label="spoVD CDS" gene 1416739..1418679 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /label="spoVD gene" promotor_-35 1418475..1418481 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-35" promotor_-10 1418496..1418504 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-10" upshifts 1418502 /Source="Nicolas_upshifts" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="upshifts" downshifts 1418652 /Source="Nicolas_upshifts" /id="D862" /incds=0 /nref=19 /ntot=91 /MaxReadThrough="4.23549" /MaxDrop="4.37308" /score="-3.90592085" /energy="-13.6" /TU="U1265,U1266" /idTUdmin="U1265" /TUdmin="-91" /isTUend="FALSE" /label="downshifts" S_feature 1418697..1418764 /Source="Nicolas_S_feature" /locus_tag="new_1586172_1586239" /HighExp="C30, G180, G135, ferm, MG 15, G150, MG 45, MG-0.1, MG 10, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S556" promotor_-35 1418734..1418738 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1418754..1418773 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" S_feature 1418766..1418854 /Source="Nicolas_S_feature" /locus_tag="new_1586241_1586329" /HighExp="G180, G150, LBGexp, Paraq, G135, Oxctl, C30, dia0, Cold, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S557" upshifts 1418766 /Source="Nicolas_upshifts" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" CDS 1418855..1420339 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /EC_number="6.3.2.13" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8436954, 10520745, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase" /protein_id="NP_389401.1" /db_xref="EnsemblGenomes-Gn:BSU15180" /db_xref="EnsemblGenomes-Tr:CAB13391" /db_xref="GOA:Q03523" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005761" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10223" /db_xref="UniProtKB/Swiss-Prot:Q03523" /translation="MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVK GYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKL QLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQK TFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAK SLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISIT AQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVR GRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKM AKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKK GDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS*" /label="murE CDS" gene 1418855..1420339 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /label="murE gene" S_feature 1420340..1420450 /Source="Nicolas_S_feature" /locus_tag="new_1587815_1587925" /HighExp="G180, G135, G150, C30, Oxctl, dia0, LBGexp, MG 25, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S558" CDS 1420451..1421425 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /EC_number="2.7.8.13" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospho-N-acetylmuramoyl-pentapeptide undecaprenyl phosphate (C55P) transferase" /protein_id="NP_389402.2" /db_xref="EnsemblGenomes-Gn:BSU15190" /db_xref="EnsemblGenomes-Tr:CAB13392" /db_xref="GOA:Q03521" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR003524" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG10224" /db_xref="UniProtKB/Swiss-Prot:Q03521" /translation="MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKS HQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIK VVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVL FMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFL VFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFK TTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL*" /label="mraY CDS" gene 1420451..1421425 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /label="mraY gene" CDS 1421426..1422781 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /EC_number="6.3.2.9" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1765076, 9218784, 10966819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate ligase" /protein_id="NP_389403.1" /db_xref="EnsemblGenomes-Gn:BSU15200" /db_xref="EnsemblGenomes-Tr:CAB13393" /db_xref="GOA:Q03522" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005762" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10225" /db_xref="UniProtKB/Swiss-Prot:Q03522" /translation="MENDQFLQKQHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFE ENEPAQKLSEKGIEVVCGEHPVSLFDQHQITILIKNPGIPYENIMVQEAEKRGIPVWT EIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKALIAGNIGTVASEVAYHAD GDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKVYLHQTAS DKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPLEEVVL PGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTVNGRKFYNDSKAT NILATSKALSAFDKPVILLAGGLDRGNGFDDLKPYMKHVKAVLTFGQTAPKLEKLGNE LGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGDMFIDAVHML K*" /label="murD CDS" gene 1421426..1422781 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /label="murD gene" promotor_-35 1422605..1422610 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-35" promotor_-10 1422626..1422644 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-10" upshifts 1422636 /Source="Nicolas_upshifts" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="upshifts" CDS 1422842..1423942 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:2509435, 9622350, 15849754, 16484183, 16850406, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509435, 9622350, 15849754, 16484183, 16850406, 27312048; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="factor for spore cortex peptidoglycan synthesis (stage V sporulation)" /protein_id="NP_389404.1" /db_xref="EnsemblGenomes-Gn:BSU15210" /db_xref="EnsemblGenomes-Tr:CAB13394" /db_xref="GOA:P07373" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR013437" /db_xref="InterPro:IPR013438" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10226" /db_xref="UniProtKB/Swiss-Prot:P07373" /translation="MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFF FAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSR SWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMC QPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLN PWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFI GGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTG ITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY*" /label="spoVE CDS" gene 1422842..1423942 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /label="spoVE gene" S_feature 1423943..1424064 /Source="Nicolas_S_feature" /locus_tag="new_1591418_1591539" /HighExp="G180, C30, G135, G150, Oxctl, Paraq, LBGexp, dia0, S3, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-" /TUshortPSig="0.569, 1, 0.436" /TUlongSig="NA" /TUlongPSig="NA" /label="S559" CDS 1424065..1425156 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /EC_number="2.4.1.227" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9244290, 11042447, 12538870, 12682299, 12813070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9244290, 11042447, 12538870, 12682299, 12813070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" /protein_id="NP_389405.2" /db_xref="EnsemblGenomes-Gn:BSU15220" /db_xref="EnsemblGenomes-Tr:CAB13395" /db_xref="GOA:P37585" /db_xref="InterPro:IPR004276" /db_xref="InterPro:IPR006009" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10227" /db_xref="UniProtKB/Swiss-Prot:P37585" /translation="MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEK KIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGY VCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFT GNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQ VLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEIT ALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQT LKEMSERTKSLGVPDAAARLYSVLEELKK*" /label="murG CDS" gene 1424065..1425156 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /label="murG gene" promotor_-35 1424545..1424554 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1424567..1424582 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1424572 /Source="Nicolas_upshifts" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" promotor_no_box 1424578..1424678 /Source="Nicolas_upshift_promotors" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1424638 /Source="Nicolas_upshifts" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1425188..1426099 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /EC_number="1.3.1.98" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11327854, 12682299, 16484183, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="NP_389406.1" /db_xref="EnsemblGenomes-Gn:BSU15230" /db_xref="EnsemblGenomes-Tr:CAB13396" /db_xref="GOA:P18579" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036635" /db_xref="SubtiList:BG10228" /db_xref="UniProtKB/Swiss-Prot:P18579" /translation="MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVD AVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGG YSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGT IEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPY SSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDL IDHVKKTIREKYEIDMHTEVEIIGGNR*" /label="murB CDS" gene 1425188..1426099 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /label="murB gene" downshifts 1426117 /Source="Nicolas_upshifts" /id="D863" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="5.78428" /MaxDrop="2.8642" /score="-7.67573434" /energy="-7.4" /TU="U1267,U1268,U1269,U1270" /idTUdmin="U1266" /TUdmin=1809 /isTUend="FALSE" /label="downshifts" CDS 1426229..1427020 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389407.1" /db_xref="EnsemblGenomes-Gn:BSU15240" /db_xref="EnsemblGenomes-Tr:CAB13397" /db_xref="GOA:P16655" /db_xref="InterPro:IPR005548" /db_xref="InterPro:IPR013685" /db_xref="InterPro:IPR026580" /db_xref="InterPro:IPR034746" /db_xref="SubtiList:BG10229" /db_xref="UniProtKB/Swiss-Prot:P16655" /translation="MNPGQDREKIVNIEERIPKIKEQRKQKANRRLISFIMLFFIMVL IIVYLQTPISKVSTISVTGNENVSKKEIIDLSDINSGDTEFWSLDKQKTEKKIQQNKL VKKAEISKSLPNKINIAIEEYKAIAYLEKDDVYYEVLENGSVLPNEVTPDDAGPILVN WTNAKKRSQMAKQLDALSNSLKQSISEIYYTPVKMDENRIKLYMNDGYVVTASIKTFA DRMKTYPSIISQLSSNKKGIIHLEVATYFEEFGKNDKAAKKEDEN*" /label="divIB CDS" gene 1426229..1427020 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /label="divIB gene" CDS 1427017..1427712 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389408.2" /db_xref="EnsemblGenomes-Gn:BSU15250" /db_xref="EnsemblGenomes-Tr:CAB13398" /db_xref="GOA:C0SPA3" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11490" /db_xref="UniProtKB/Swiss-Prot:C0SPA3" /translation="MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAAETEEWKKEY ALRDELLKQEKENKKFEKELYQKQNKVRQAENKLKKEKSEYYNVLEDTEKYRMYIGEV GVQGEGVEVTLEDASYIPEGENVNSYIVHESHIFQVVNELYISGAAAVAVNGQRLTHD SYIKCNGPVVTVDGVQHPAPFTVSAIGDPDVLLPSLNIAGGLIDQLSMDHISVSAEKE KNVQMKPILKTKE*" /label="ylxW CDS" gene 1427017..1427712 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /label="ylxW gene" CDS 1427735..1428442 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183, 18179421" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389409.2" /db_xref="EnsemblGenomes-Gn:BSU15260" /db_xref="EnsemblGenomes-Tr:CAB13399" /db_xref="GOA:Q45544" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11489" /db_xref="UniProtKB/Swiss-Prot:Q45544" /translation="MKIKRSFISISVLMVIFGLMISVQFNSLKHPKVRDTRDMWDIRE ELTSEQKKQEKLLAEINKYDKLLNSYSQTKEMTKETALNNTLQSLKKTAGMTDITGSG IVITISPLFSESLTGEPIENPPPDLLKKLINELNSYGAEHISINERRVVNHTVIRDIN GTTKIDGYALDDYPLTVKVLAKDPDMLHSRVKGSGLEDLFASENLALKAGKSESKLTL KAYDRPLDVQQLKLLKD*" /label="ylxX CDS" gene 1427735..1428442 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /label="ylxX gene" CDS 1428460..1428825 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1569582, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (small basic protein)" /protein_id="NP_389410.1" /db_xref="EnsemblGenomes-Gn:BSU15270" /db_xref="EnsemblGenomes-Tr:CAB13400" /db_xref="GOA:P28265" /db_xref="InterPro:IPR009709" /db_xref="SubtiList:BG10230" /db_xref="UniProtKB/Swiss-Prot:P28265" /translation="MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGG IRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVI RRNLLTKWTLSKKNKKNVI*" /label="sbp CDS" gene 1428460..1428825 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /label="sbp gene" promotor_-35 1428677..1428680 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1428696..1428715 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1428712 /Source="Nicolas_upshifts" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" S_feature 1428826..1428998 /Source="Nicolas_S_feature" /locus_tag="new_1596301_1596473" /HighExp="T3.0H, T2.30H, S2, T3.30H, Lbtran, T4.0H, T5.0H, T1.30H, S1, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigWXY, SigA" /TUshortPSig="0.989, 0.0739, 1, 1" /TUlongSig="SigEF, Sig-" /TUlongPSig="0.569, 0.436" /label="S560" CDS 1428999..1430321 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein essential for Z-ring assembly" /protein_id="NP_389411.2" /db_xref="EnsemblGenomes-Gn:BSU15280" /db_xref="EnsemblGenomes-Tr:CAB13401" /db_xref="GOA:P28264" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR020823" /db_xref="SubtiList:BG10231" /db_xref="UniProtKB/Swiss-Prot:P28264" /translation="MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKK GSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEI QVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLIT GSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAV FQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVT VIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGV MSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQ EIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE*" /label="ftsA CDS" gene 1428999..1430321 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /label="ftsA gene" upshifts complement(1429206) /Source="Nicolas_upshifts" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1429210..1429214) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1429229..1429233) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1430357..1431505 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389412.2" /db_xref="EnsemblGenomes-Gn:BSU15290" /db_xref="EnsemblGenomes-Tr:CAB13402" /db_xref="GOA:P17865" /db_xref="InterPro:IPR000158" /db_xref="InterPro:IPR003008" /db_xref="InterPro:IPR008280" /db_xref="InterPro:IPR018316" /db_xref="InterPro:IPR020805" /db_xref="InterPro:IPR024757" /db_xref="InterPro:IPR036525" /db_xref="InterPro:IPR037103" /db_xref="PDB:2RHH" /db_xref="PDB:2RHJ" /db_xref="PDB:2RHL" /db_xref="PDB:2RHO" /db_xref="PDB:2VAM" /db_xref="PDB:2VXY" /db_xref="PDB:4U39" /db_xref="SubtiList:BG10232" /db_xref="UniProtKB/Swiss-Prot:P17865" /translation="MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVN TDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVT AGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDT LIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIM SNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQ EAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSI KTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG*" /label="ftsZ CDS" gene 1430357..1431505 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /label="ftsZ gene" downshifts 1431479 /Source="Nicolas_upshifts" /id="D864" /incds=0 /nref=226 /ntot=389 /MaxReadThrough="2.85051" /MaxDrop="7.70428" /score="34.7919519" /energy="-13.7" /TU="U1267,U1271" /idTUdmin="U1269" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR join(1431600,1431607) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs20" N_region 1431601..1431606 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs20" S_feature <1431607..1431652 /Source="Nicolas_S_feature" /locus_tag="new_1606413_1606501" /HighExp="LoTm, S7, S8, BT, S6, S4, G/S, S3, S2, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S565" promotor_-35 1431617..1431624 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1431637..1431656 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1431654 /Source="Nicolas_upshifts" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1431711..1432505 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683, 18083814; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389417.2" /db_xref="EnsemblGenomes-Gn:BSU15340" /db_xref="EnsemblGenomes-Tr:CAB13408" /db_xref="GOA:O31723" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13370" /db_xref="UniProtKB/Swiss-Prot:O31723" /translation="MILQLDNVSLKRNGKWILKDIHWKVEEKENWVLYGLNGAGKTAL LNMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALS GAYASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADP ELLILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQ GEVFGSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA*" /label="ylmA CDS" gene 1431711..1432505 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /label="ylmA gene" promotor_-35 1432423..1432426 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-35" promotor_-10 1432441..1432460 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-10" upshifts 1432449 /Source="Nicolas_upshifts" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="upshifts" misc_RNA 1432518..1432619 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswE RNA" gene 1432518..1432619 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /label="tswE gene" downshifts 1432606 /Source="Nicolas_upshifts" /id="D867" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="5.58534" /MaxDrop="4.3688" /score="-2.39598083" /energy="-7.1" /TU="U1278,U1279" /idTUdmin="U1274" /TUdmin=971 /isTUend="FALSE" /label="downshifts" CDS 1432707..1433987 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /EC_number="3.5.1.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17618314" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17618314; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-4-amino-5-aminomethyl-2- methylpyrimidinedeformylase" /protein_id="NP_389418.2" /db_xref="EnsemblGenomes-Gn:BSU15350" /db_xref="EnsemblGenomes-Tr:CAB13409" /db_xref="GOA:O31724" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13371" /db_xref="UniProtKB/Swiss-Prot:O31724" /translation="MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQS WIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWK HDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGE AGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGG GTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADE CRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIF PALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHN AHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ*" /label="thiQ CDS" gene 1432707..1433987 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /label="thiQ gene" misc_feature complement(1433928..1433944) /Source="Nicolas_upshift_promotors" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1433933) /Source="Nicolas_upshifts" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1434008..1434013 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-35" promotor_-10 1434029..1434047 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-10" upshifts 1434033 /Source="Nicolas_upshifts" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="upshifts" CDS 1434070..1434315 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /experiment="publication(s) with functional evidences, PMID:12429060, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12429060, 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="essential sporulation protein" /protein_id="NP_389419.1" /db_xref="EnsemblGenomes-Gn:BSU15360" /db_xref="EnsemblGenomes-Tr:CAB13410" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13372" /db_xref="UniProtKB/Swiss-Prot:O31725" /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGN GKVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA*" /label="ylmC CDS" gene 1434070..1434315 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /label="ylmC gene" promotor_-35 1434231..1434239 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1434250..1434268 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1434258 /Source="Nicolas_upshifts" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1434316..1434426 /Source="Nicolas_S_feature" /locus_tag="new_1609165_1609275" /HighExp="T3.0H, S2, S1, T4.0H, T3.30H, T5.0H, T2.0H, BC, Gly, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34150000000000003" /TUshortSig="SigH, SigEF, SigA, SigA" /TUshortPSig="1, 0.998, 0.976, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S566" misc_feature 1434418..1434437 /Source="Nicolas_upshift_promotors" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1434428 /Source="Nicolas_upshifts" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1434478..1435314 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16498617, 19737354; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved protein with laccase domain" /protein_id="NP_389420.1" /db_xref="EnsemblGenomes-Gn:BSU15370" /db_xref="EnsemblGenomes-Tr:CAB13411" /db_xref="GOA:O31726" /db_xref="InterPro:IPR003730" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG13373" /db_xref="UniProtKB/Swiss-Prot:O31726" /translation="MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQK PFESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKG AREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIG REMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKA QYQLDLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMK EA*" /label="ylmD CDS" gene 1434478..1435314 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /label="ylmD gene" CDS 1435321..1436013 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14526035, 24097949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PLP-containing enzyme" /protein_id="NP_389421.1" /db_xref="EnsemblGenomes-Gn:BSU15380" /db_xref="EnsemblGenomes-Tr:CAB13412" /db_xref="GOA:O31727" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR011078" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG13374" /db_xref="UniProtKB/Swiss-Prot:O31727" /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQE AVDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLS LAKEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAP LTDDQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGS SLVGNETGGVQQ*" /label="ylmE CDS" gene 1435321..1436013 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /label="ylmE gene" CDS 1436010..1436465 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14526035, 16420366, 16796675, 18782755, 22912848, 24218584" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526035, 16420366, 16796675, 18782755, 22912848, 24218584; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division machinery factor" /protein_id="NP_389422.3" /db_xref="EnsemblGenomes-Gn:BSU15390" /db_xref="EnsemblGenomes-Tr:CAB13413" /db_xref="GOA:O31728" /db_xref="InterPro:IPR007561" /db_xref="InterPro:IPR023052" /db_xref="PDB:3ZIH" /db_xref="PDB:3ZII" /db_xref="SubtiList:BG13375" /db_xref="UniProtKB/Swiss-Prot:O31728" /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGN KPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKR IVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW*" /label="sepF CDS" gene 1436010..1436465 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /label="sepF gene" CDS 1436472..1436744 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14526035, 19966467, 20359373; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, distribution of nucleoids and osmotic tolerance" /protein_id="NP_389423.1" /db_xref="EnsemblGenomes-Gn:BSU15400" /db_xref="EnsemblGenomes-Tr:CAB13414" /db_xref="GOA:O31729" /db_xref="InterPro:IPR003425" /db_xref="SubtiList:BG13376" /db_xref="UniProtKB/Swiss-Prot:O31729" /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLAS ICEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF*" /label="ylmG CDS" gene 1436472..1436744 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /label="ylmG gene" downshifts 1436733 /Source="Nicolas_upshifts" /id="D868" /incds=0 /nref=16 /ntot=97 /MaxReadThrough="6.19839" /MaxDrop="4.93537" /score="-6.17078585" /energy="-15.2" /TU="U1278,U1281,U1282,U1283" /idTUdmin="U1281" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" CDS 1436805..1437578 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10093218, 14526035, 21141807; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, RNA-binding fold" /protein_id="NP_389424.1" /db_xref="EnsemblGenomes-Gn:BSU15410" /db_xref="EnsemblGenomes-Tr:CAB13415" /db_xref="GOA:P71020" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11856" /db_xref="UniProtKB/Swiss-Prot:P71020" /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQV ILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVD HRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKID LSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPS YIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK*" /label="ylmH CDS" gene 1436805..1437578 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /label="ylmH gene" promotor_-35 1437294..1437301 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1437315..1437333 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1437338 /Source="Nicolas_upshifts" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1437579..1437671 /Source="Nicolas_S_feature" /locus_tag="new_1612428_1612520" /HighExp="C90, M0t90, C30, GM-0.1, Glucon, MG 5, GM 45, GM 5, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigH, SigEF, SigA" /TUshortPSig="0.973, 1, 1, 0.998, 0.989" /TUlongSig="SigA" /TUlongPSig="0.976" /label="S567" CDS 1437672..1438166 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389425.1" /db_xref="EnsemblGenomes-Gn:BSU15420" /db_xref="EnsemblGenomes-Tr:CAB13416" /db_xref="GOA:P71021" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR019933" /db_xref="PDB:2WUJ" /db_xref="PDB:2WUK" /db_xref="SubtiList:BG11835" /db_xref="UniProtKB/Swiss-Prot:P71021" /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKT ELEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADR IINESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVF EEKE*" /label="divIVA CDS" gene 1437672..1438166 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /label="divIVA gene" promotor_-35 1438179..1438186 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1438200..1438219 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1438207 /Source="Nicolas_upshifts" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1438229..1438455 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /product="T-box riboswitch specific of isoleucine tRNA" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /label="iswA RNA" gene 1438229..1438455 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /label="iswA gene" downshifts 1438422 /Source="Nicolas_upshifts" /id="D869" /incds=0 /nref=43 /ntot=100 /MaxReadThrough="7.76706" /MaxDrop="5.97038" /score="48.8352635" /energy="-19.4" /TU="U1278,U1282,U1283,U1284,U1285" /idTUdmin="U1281" /TUdmin=237 /isTUend="FALSE" /label="downshifts" CDS 1438508..1441273 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /EC_number="6.1.1.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16697013, 17043414, 17095543, 28139725; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucyl-tRNA synthetase" /protein_id="NP_389426.2" /db_xref="EnsemblGenomes-Gn:BSU15430" /db_xref="EnsemblGenomes-Tr:CAB13417" /db_xref="GOA:Q45477" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002301" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023585" /db_xref="InterPro:IPR033708" /db_xref="SubtiList:BG11792" /db_xref="UniProtKB/Swiss-Prot:Q45477" /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERT KDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIE TALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEY EAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDG KGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASAC GFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDF IIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHS YPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDW CISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFT HPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSL STAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSV DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLI KLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSM QTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEK FDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVS ELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEI VEKYYQK*" /label="ileS CDS" gene 1438508..1441273 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /label="ileS gene" downshifts 1441264 /Source="Nicolas_upshifts" /id="D870" /incds=0 /nref=233 /ntot=261 /MaxReadThrough="2.6695" /MaxDrop="6.91924" /score="40.2175565" /energy="-13.9" /TU="NA" /idTUdmin="U1278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(1441319) /Source="Nicolas_upshifts" /id="D871" /incds=0 /nref=6 /ntot=17 /MaxReadThrough="1.29709" /MaxDrop="3.66645" /score="13.8608728" /energy="-15.6" /TU="NA" /idTUdmin="U1275" /TUdmin="-12534" /isTUend="FALSE" /label="downshifts" promotor_-35 1441354..1441360 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-35" promotor_-10 1441375..1441386 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-10" upshifts 1441375 /Source="Nicolas_upshifts" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="upshifts" CDS 1441418..1441792 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15496987, 23123912, 23678950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15496987, 23123912, 23678950; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related RNA polymerase-binding factor" /protein_id="NP_389427.2" /db_xref="EnsemblGenomes-Gn:BSU15440" /db_xref="EnsemblGenomes-Tr:CAB13418" /db_xref="GOA:Q45478" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR016841" /db_xref="InterPro:IPR020458" /db_xref="SubtiList:BG11795" /db_xref="UniProtKB/Swiss-Prot:Q45478" /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQK ATLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQ FEKKTLPIWKSTDIEYGQALYE*" /label="ylyA CDS" gene 1441418..1441792 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /label="ylyA gene" promotor_-35 1441824..1441828 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" upshifts 1441843 /Source="Nicolas_upshifts" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" promotor_-10 1441844..1441863 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" CDS 1441895..1442359 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /EC_number="3.4.23.36" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9880550, 9882689, 10497172, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880550, 9882689, 10497172, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="signal peptidase II" /protein_id="NP_389428.1" /db_xref="EnsemblGenomes-Gn:BSU15450" /db_xref="EnsemblGenomes-Tr:CAB13419" /db_xref="GOA:Q45479" /db_xref="InterPro:IPR001872" /db_xref="SubtiList:BG11793" /db_xref="UniProtKB/Swiss-Prot:Q45479" /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHR NTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFID RAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ*" /label="lspA CDS" gene 1441895..1442359 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /label="lspA gene" CDS 1442361..1443272 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15078091, 15928344, 17188032, 17937767, 18032607, 20817755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389429.3" /db_xref="EnsemblGenomes-Gn:BSU15460" /db_xref="EnsemblGenomes-Tr:CAB13420" /db_xref="GOA:Q45480" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11796" /db_xref="UniProtKB/Swiss-Prot:Q45480" /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVV NGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHP APGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQ LVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERF QDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHP RTGEYVEFEAPLPEDMAELIENLRKNG*" /label="rluD CDS" gene 1442361..1443272 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /label="rluD gene" promotor_-35 1443267..1443274 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" promotor_-10 1443289..1443308 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" upshifts 1443303 /Source="Nicolas_upshifts" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" misc_RNA 1443312..1443428 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaA RNA" gene 1443312..1443428 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /label="pyaA gene" CDS 1443455..1444000 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /EC_number="2.4.2.9" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7798145, 9932459, 12482852, 15716449, 17322189, 18678934" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 9932459, 12482852, 15716449, 17322189, 18678934; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional attenuator and uracil phosphoribosyltransferase activity" /protein_id="NP_389430.1" /db_xref="EnsemblGenomes-Gn:BSU15470" /db_xref="EnsemblGenomes-Tr:CAB13421" /db_xref="GOA:P39765" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR023050" /db_xref="InterPro:IPR029057" /db_xref="PDB:1A3C" /db_xref="PDB:1A4X" /db_xref="PDB:4P82" /db_xref="SubtiList:BG10712" /db_xref="UniProtKB/Swiss-Prot:P39765" /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGI YLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVI LVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSE KVMVQLDEVDQNDLVAIYENE*" /label="pyrR CDS" gene 1443455..1444000 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /label="pyrR gene" downshifts complement(1443649) /Source="Nicolas_upshifts" /id="D872" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="1.85132" /MaxDrop="2.50006" /score="0.812637138" /energy="-7" /TU="NA" /idTUdmin="U1275" /TUdmin="-14864" /isTUend="FALSE" /label="downshifts" downshifts 1443991 /Source="Nicolas_upshifts" /id="D873" /incds=0 /nref=13 /ntot=149 /MaxReadThrough="8.16191" /MaxDrop="3.4492" /score="16.3570883" /energy="-11.5" /TU="U1287,U1288" /idTUdmin="U1286" /TUdmin=704 /isTUend="FALSE" /label="downshifts" misc_RNA 1444004..1444121 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaB RNA" gene 1444004..1444121 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /label="pyaB gene" CDS 1444174..1445481 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8206848, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uracil permease" /protein_id="NP_389431.2" /db_xref="EnsemblGenomes-Gn:BSU15480" /db_xref="EnsemblGenomes-Tr:CAB13422" /db_xref="GOA:P39766" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR029935" /db_xref="SubtiList:BG10992" /db_xref="UniProtKB/Swiss-Prot:P39766" /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMS PAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGL VYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYS LKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWF AVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHR SIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKIS ALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAF IQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI*" /label="pyrP CDS" gene 1444174..1445481 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /label="pyrP gene" misc_RNA 1445482..1445596 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaC RNA" gene 1445482..1445596 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /label="pyaC gene" CDS 1445627..1446541 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /EC_number="2.1.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8535162, 16321950, 21663747" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8535162, 16321950, 21663747; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="NP_389432.2" /db_xref="EnsemblGenomes-Gn:BSU15490" /db_xref="EnsemblGenomes-Tr:CAB13423" /db_xref="GOA:P05654" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR036901" /db_xref="PDB:2AT2" /db_xref="PDB:3R7D" /db_xref="PDB:3R7F" /db_xref="PDB:3R7L" /db_xref="SubtiList:BG10713" /db_xref="UniProtKB/Swiss-Prot:P05654" /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFF EPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSE DEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSR VARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQ SAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKN GVFIRMAVIQRALQTNVKRGEAAYVISH*" /label="pyrB CDS" gene 1445627..1446541 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /label="pyrB gene" CDS 1446525..1447811 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /EC_number="3.5.2.3" /function="2: Purines, pyrimidines, nucleosides, and nucleotides" /experiment="publication(s) with functional evidences, PMID:7516791, 16522191, 21045288" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7516791, 16522191, 21045288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotase" /protein_id="NP_389433.2" /db_xref="EnsemblGenomes-Gn:BSU15500" /db_xref="EnsemblGenomes-Tr:CAB13424" /db_xref="GOA:P25995" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10714" /db_xref="UniProtKB/Swiss-Prot:P25995" /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVI DAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKE QMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVL LAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKM NPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLL YTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETF LSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK*" /label="pyrC CDS" gene 1446525..1447811 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /label="pyrC gene" CDS 1447808..1448902 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1709162, 11390694, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit)" /protein_id="NP_389434.1" /db_xref="EnsemblGenomes-Gn:BSU15510" /db_xref="EnsemblGenomes-Tr:CAB13425" /db_xref="GOA:P25993" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10715" /db_xref="UniProtKB/Swiss-Prot:P25993" /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDP SYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKM KNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAK TAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSN GPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKE LATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASP GPEDANHLFDRFIEMIETTEKEGEAVCQNA*" /label="pyrAA CDS" gene 1447808..1448902 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /label="pyrAA gene" CDS 1448887..1452102 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 216664, 6120161, 10732707, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (large subunit)" /protein_id="NP_389435.1" /db_xref="EnsemblGenomes-Gn:BSU15520" /db_xref="EnsemblGenomes-Tr:CAB13426" /db_xref="GOA:P25994" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR033937" /db_xref="InterPro:IPR036897" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10716" /db_xref="UniProtKB/Swiss-Prot:P25994" /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEV ILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVEL SERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVS QIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEY EVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALG IEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEM MNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEES LLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHE FSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYS LRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQ GVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDL EQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQP LGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQH PVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKK KIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLA TKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKD STLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAG YLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVEN GVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI*" /label="pyrAB CDS" gene 1448887..1452102 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /label="pyrAB gene" CDS 1452099..1452869 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /EC_number="1.3.98.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:169225, 10545205, 11188687, 15299876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 169225, 10545205, 11188687, 15299876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (electron transfer subunit)" /protein_id="NP_389436.1" /db_xref="EnsemblGenomes-Gn:BSU15530" /db_xref="EnsemblGenomes-Tr:CAB13427" /db_xref="GOA:P25983" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR012165" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR019480" /db_xref="InterPro:IPR023455" /db_xref="InterPro:IPR037117" /db_xref="SubtiList:BG10717" /db_xref="UniProtKB/Swiss-Prot:P25983" /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSE AVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVN EVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDT YVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERM GCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL*" /label="pyrK CDS" gene 1452099..1452869 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /label="pyrK gene" CDS 1452869..1453804 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /EC_number="1.3.1.15" /experiment="publication(s) with functional evidences, PMID:4380263, 10545205" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4380263, 10545205; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (catalytic subunit)" /protein_id="NP_389437.1" /db_xref="EnsemblGenomes-Gn:BSU15540" /db_xref="EnsemblGenomes-Tr:CAB13428" /db_xref="GOA:P25996" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /db_xref="InterPro:IPR012135" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024920" /db_xref="InterPro:IPR033888" /db_xref="SubtiList:BG10718" /db_xref="UniProtKB/Swiss-Prot:P25996" /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKA TTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQ VDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAV KPVAIRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEI IEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA*" /label="pyrD CDS" gene 1452869..1453804 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /label="pyrD gene" CDS 1453773..1454492 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /EC_number="4.1.1.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10681442, 11390694, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10681442, 11390694, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="NP_389438.1" /db_xref="EnsemblGenomes-Gn:BSU15550" /db_xref="EnsemblGenomes-Tr:CAB13429" /db_xref="GOA:P25971" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014732" /db_xref="InterPro:IPR018089" /db_xref="PDB:1DBT" /db_xref="SubtiList:BG10719" /db_xref="UniProtKB/Swiss-Prot:P25971" /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGP SIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEG LEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVV CSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSIT KAEDPVKAYKAVRLEWEGIKS*" /label="pyrF CDS" gene 1453773..1454492 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /label="pyrF gene" CDS 1454471..1455121 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /EC_number="2.4.2.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9305779, 22447609, 23405251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotate phosphoribosyltransferase" /protein_id="NP_389439.1" /db_xref="EnsemblGenomes-Gn:BSU15560" /db_xref="EnsemblGenomes-Tr:CAB13430" /db_xref="GOA:P25972" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR004467" /db_xref="InterPro:IPR023031" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10720" /db_xref="UniProtKB/Swiss-Prot:P25972" /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNR LTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSK PKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGL PKAEEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK*" /label="pyrE CDS" gene 1454471..1455121 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /label="pyrE gene" downshifts 1455123 /Source="Nicolas_upshifts" /id="D874" /incds=0 /nref=17 /ntot=184 /MaxReadThrough="3.91018" /MaxDrop="5.49939" /score="33.4515727" /energy="-9" /TU="U1287,U1288" /idTUdmin="U1287" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" S_feature 1455168..1455240 /Source="Nicolas_S_feature" /locus_tag="new_1630017_1630089" /HighExp="Cold, Gly, MG 5, S0, LPh, M/G, GM 60, MG t5, Mal, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S568" promotor_-35 1455220..1455227 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1455241..1455260 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1455242 /Source="Nicolas_upshifts" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1455266..1455371 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /label="mswE RNA" gene 1455266..1455371 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /label="mswE gene" S_feature 1455372..1455532 /Source="Nicolas_S_feature" /locus_tag="new_1630221_1630381" /HighExp="MG 10, B60, MG 5, MG t5, M9-exp, MG 25, MG 60, MG 15, GM 90, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S569" CDS 1455533..1456234 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10094622, 11004190, 12072441, 16267287, 18456801" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 11004190, 12072441, 16267287, 18456801; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(phospho)adenosine phosphosulfate reductase" /protein_id="NP_389440.1" /db_xref="EnsemblGenomes-Gn:BSU15570" /db_xref="EnsemblGenomes-Tr:CAB13431" /db_xref="GOA:P94498" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11930" /db_xref="UniProtKB/Swiss-Prot:P94498" /translation="MLTYDNWEEPTITFPEDDPYKGALSVLKWAYGHYGDQLVYACSF GIEGIVLIDLIYKVKKDAEIVFLDTGLHFKETYETIERVKERYPGLNIILKKPDLTLE EQAEEHGDKLWEREPNQCCYLRKVVPLREALSGHPAWLSGLRRDQGPSRANTNFLNKD EKFKSVKVCPLIHWTWKDIWRYTSRNELDYNPLHDQGYPSIGCAPCTSPAFTAEDLRS GRWNGMAKTECGLHE*" /label="cysH CDS" gene 1455533..1456234 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /label="cysH gene" CDS 1456246..1457310 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 10784039, 11004190, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 10784039, 11004190, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfate permease" /protein_id="NP_389441.1" /db_xref="EnsemblGenomes-Gn:BSU15580" /db_xref="EnsemblGenomes-Tr:CAB13432" /db_xref="GOA:O34734" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13377" /db_xref="UniProtKB/Swiss-Prot:O34734" /translation="MELAAILFSLFFAMNIGASGAAASMGVAYGSGAIKKKTYALILC AVGVFAGAVIGGGEVVKTISSGIIPEQTITLTIVCIIIGAAALSLFTANLLGIPLSTS EVTVGAVVGVGVAYKVLFVNNLLIIVSFWVFVPLFAFGFTYFVSKLFRYFKIEVKSSK KQKILGIVLLVAGFFEAFSAGMNNVANAVGPLVAAGVLDVGKGTLYGGAFVALGALLL GRRVLETNGKKITRFSKGEGILLSGTGAGLVIISSVFGMPVPLAQVTSSSIIGIGMAK NGPNVFHKQVVQTMLKVWIVSPFLSLSISYLLVSLFLKADYYSIFIMVSVLLAAGGAI SLTKAIRKERRSVHEQGGGI*" /label="cysP CDS" gene 1456246..1457310 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /label="cysP gene" CDS 1457359..1458507 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /EC_number="2.7.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 11004190, 11274114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfate adenylyltransferase" /protein_id="NP_389442.1" /db_xref="EnsemblGenomes-Gn:BSU15590" /db_xref="EnsemblGenomes-Tr:CAB13433" /db_xref="GOA:O34764" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13378" /db_xref="UniProtKB/Swiss-Prot:O34764" /translation="MSLAPHGGTLVNRVDESYDVSGIQKEIELDLISFADLELIGIGA YSPIEGFFNEKDYVSVVENMRLSSGVVWSLPITLPVDAQKAAELSLGETVKLTYEGET YGVIQIEDLYVPDKQKEAVNVYKTDEQEHPGVKKLFSRGNTYVGGPITLIKKASKQFP EFTFEPSETRRQFAEKGWETIVGFQTRNPVHRAHEYIQKTALETVDGLFLNPLVGETK SDDIPADVRMESYQVLLDHYYPKDRVFLGVFLAAMRYAGPREAIFHALVRKNYGCTHF IVGRDHAGVGDYYGTYEAQELFDTFKPEELGITPLKFEHSFFCKKCGNMGTAKTCPHG REHHVILSGTKVRGMLRDGVLPPAEFSRKEVVEVLIKGMKKKEEVGVS*" /label="sat CDS" gene 1457359..1458507 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /label="sat gene" upshifts complement(1457448) /Source="Nicolas_upshifts" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1457460..1457464) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1457482..1457483) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1458520..1459113 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /EC_number="2.7.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1332767, 10094622, 11004190, 19067028, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylylsulfate kinase" /protein_id="NP_389443.1" /db_xref="EnsemblGenomes-Gn:BSU15600" /db_xref="EnsemblGenomes-Tr:CAB13434" /db_xref="GOA:O34577" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13379" /db_xref="UniProtKB/Swiss-Prot:O34577" /translation="MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIAN AAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVI TAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS*" /label="cysC CDS" gene 1458520..1459113 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /label="cysC gene" S_feature 1459114..1459211 /Source="Nicolas_S_feature" /locus_tag="new_1633963_1634060" /HighExp="MG 10, B36, MG 5, MG t5, B60, MG 15, MG 90, MG-0.2, MG 60, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S570" CDS 1459212..1459985 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /EC_number="2.1.1.107" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1906874, 11004190, 10094622, 19154787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III and precorrin-1 C-methyltransferase" /protein_id="NP_389444.1" /db_xref="EnsemblGenomes-Gn:BSU15610" /db_xref="EnsemblGenomes-Tr:CAB13435" /db_xref="GOA:O34744" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG13380" /db_xref="UniProtKB/Swiss-Prot:O34744" /translation="MGKVYIVGAGPGDPDLLTIKALKAIEKADVILYDRLVNKEILQY AKEQADLIYCGKLPDFHTMKQETINRFLVKYAQKGKMVVRLKGGDPFVFGRGGEEAEC LSENGIPFEIIPGITSGIAAAAYAGIPVTHRDAGSNVAFVTGHYKKEEDFEEKWKALA TGIDTLVIYMGIKNVQQIERKLLENGRDGSTPAAFIHWGTTDKQKSVFCTVDTLSETV IKENITNPSLIVIGNVVNYHYKLEWFESELKKQDLSEAL*" /label="sumT CDS" gene 1459212..1459985 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /label="sumT gene" promotor_-35 1459890..1459897 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1459912..1459931 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1459913 /Source="Nicolas_upshifts" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" CDS 1459988..1460773 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /EC_number="4.99.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirohydrochlorin ferrochelatase" /protein_id="NP_389445.1" /db_xref="EnsemblGenomes-Gn:BSU15620" /db_xref="EnsemblGenomes-Tr:CAB13436" /db_xref="GOA:O34632" /db_xref="InterPro:IPR002762" /db_xref="SubtiList:BG13381" /db_xref="UniProtKB/Swiss-Prot:O34632" /translation="MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLEL QEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKP IGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKE VIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNV YLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH*" /label="sirB CDS" gene 1459988..1460773 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /label="sirB gene" CDS 1460754..1461242 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /EC_number="1.3.1.76" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752, 18588505; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="precorrin-2 dehydrogenase" /protein_id="NP_389446.1" /db_xref="EnsemblGenomes-Gn:BSU15630" /db_xref="EnsemblGenomes-Tr:CAB13437" /db_xref="GOA:O34813" /db_xref="InterPro:IPR006367" /db_xref="InterPro:IPR028161" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13382" /db_xref="UniProtKB/Swiss-Prot:O34813" /translation="MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVE PEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSD AELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR KK*" /label="sirC CDS" gene 1460754..1461242 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /label="sirC gene" downshifts 1461222 /Source="Nicolas_upshifts" /id="D875" /incds=0 /nref=256 /ntot=267 /MaxReadThrough="2.85828" /MaxDrop="8.90139" /score="26.5923498" /energy="-16.6" /TU="U1289" /idTUdmin="U1291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1461269) /Source="Nicolas_upshifts" /id="D876" /incds=0 /nref=149 /ntot=238 /MaxReadThrough="1.71588" /MaxDrop="5.36964" /score="15.559144" /energy="-16.6" /TU="NA" /idTUdmin="U1292" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1461282..1463000) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11238985, 17586671, 24646681, 28294433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA modification protein" /protein_id="NP_389447.1" /db_xref="EnsemblGenomes-Gn:BSU15640" /db_xref="EnsemblGenomes-Tr:CAB13438" /db_xref="InterPro:IPR008532" /db_xref="SubtiList:BG13383" /db_xref="UniProtKB/Swiss-Prot:O34693" /translation="MHMSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAK GKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIM IFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLP GQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAG LANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELL DRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELL TANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVV EEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNP VLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQT IMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTV IKLKKS*" /label="fbnA CDS" gene complement(1461282..1463000) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /label="fbnA gene" promotor_-10 complement(1463022..1463041) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1463036..1463041 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-35" upshifts complement(1463036) /Source="Nicolas_upshifts" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1463054..1463059) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1463057..1463075 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-10" upshifts 1463061 /Source="Nicolas_upshifts" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="upshifts" CDS 1463116..1465788 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12161109, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12161109, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="P-type calcium transport ATPase (sporulation)" /protein_id="NP_389448.1" /db_xref="EnsemblGenomes-Gn:BSU15650" /db_xref="EnsemblGenomes-Tr:CAB13439" /db_xref="GOA:O34431" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR004014" /db_xref="InterPro:IPR005782" /db_xref="InterPro:IPR006068" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13384" /db_xref="UniProtKB/Swiss-Prot:O34431" /translation="MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGK KTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAE QSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEI EESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMG KIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVS LAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQN KMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIE KRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQD RKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYR PIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETA KAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQEN GHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGR NIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGM DQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQ TIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPI FHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK*" /label="tcaB CDS" gene 1463116..1465788 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /label="tcaB gene" promotor_-10 complement(1464521..1464540) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1464532) /Source="Nicolas_upshifts" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1464555..1464562) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1465794..1465813 /Source="Nicolas_upshift_promotors" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1465797..1465870 /Source="Nicolas_S_feature" /locus_tag="new_1640646_1640719" /HighExp="LPhT, LBGstat, T3.0H, H2O2, T3.30H, Salt, B60, Lbexp, UNK1, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.994, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S571" upshifts 1465797 /Source="Nicolas_upshifts" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1465871..1466746 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389449.1" /db_xref="EnsemblGenomes-Gn:BSU15660" /db_xref="EnsemblGenomes-Tr:CAB13440" /db_xref="InterPro:IPR005229" /db_xref="InterPro:IPR013527" /db_xref="InterPro:IPR013551" /db_xref="SubtiList:BG13385" /db_xref="UniProtKB/Swiss-Prot:O34441" /translation="MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLY FEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLS AEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCL MHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDI TEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEM KSSIEKIKEQVQNIE*" /label="yloC CDS" gene 1465871..1466746 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /label="yloC gene" CDS 1466823..1467092 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116, 23396918, 23646920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116, 23396918, 23646920; Product type r: regulator" /codon_start=1 /transl_table=11 /product="essential sporulation DNA binding protein; regulator of biofilm formation" /protein_id="NP_570902.1" /db_xref="EnsemblGenomes-Gn:BSU15670" /db_xref="EnsemblGenomes-Tr:CAE01452" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG14185" /db_xref="UniProtKB/Swiss-Prot:Q7WY72" /translation="MTIKLINIGFGNIISANRMISIVSPESAPIKRMIQDARDRGMLI DATYGRRTRAVVVMDSDHIILSAVQPETVAHRLSVKEEIMDEGQG*" /label="remA CDS" gene 1466823..1467092 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /label="remA gene" misc_feature complement(1466903..1466907) /Source="Nicolas_upshift_promotors" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1466908) /Source="Nicolas_upshifts" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1467100..1467714 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /EC_number="2.7.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17012781, 24722991" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17012781, 24722991; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanylate kinase" /protein_id="NP_389450.2" /db_xref="EnsemblGenomes-Gn:BSU15680" /db_xref="EnsemblGenomes-Tr:CAB13441" /db_xref="GOA:O34328" /db_xref="InterPro:IPR008144" /db_xref="InterPro:IPR008145" /db_xref="InterPro:IPR017665" /db_xref="InterPro:IPR020590" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13386" /db_xref="UniProtKB/Swiss-Prot:O34328" /translation="MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSP REGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLE IEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMM DAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE*" /label="gmk CDS" gene 1467100..1467714 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /label="gmk gene" CDS 1467718..1467921 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12089032, 16159791, 17233676, 24476911, 25878038; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega subunit of RNA polymerase" /protein_id="NP_389451.1" /db_xref="EnsemblGenomes-Gn:BSU15690" /db_xref="EnsemblGenomes-Tr:CAB13442" /db_xref="GOA:O35011" /db_xref="InterPro:IPR003716" /db_xref="InterPro:IPR006110" /db_xref="InterPro:IPR012293" /db_xref="InterPro:IPR036161" /db_xref="SubtiList:BG13387" /db_xref="UniProtKB/Swiss-Prot:O35011" /translation="MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISH KYVGKALEEIDAGLLSFEKEDRE*" /label="rpoZ CDS" gene 1467718..1467921 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /label="rpoZ gene" downshifts 1467910 /Source="Nicolas_upshifts" /id="D877" /incds=0 /nref=118 /ntot=257 /MaxReadThrough="5.65143" /MaxDrop="4.7291" /score="-8.13961715" /energy="-7.7" /TU="U1293,U1295" /idTUdmin="U1293" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS 1468002..1469222 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /EC_number="4.1.1.36" /EC_number="6.3.2.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11278255, 11358972, 12140293, 14686929, 15530362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coenzyme A biosynthesis bifunctional protein CoaBC; phosphopantothenoylcysteine synthetase/decarboxylase" /protein_id="NP_389452.1" /db_xref="EnsemblGenomes-Gn:BSU15700" /db_xref="EnsemblGenomes-Tr:CAB13443" /db_xref="GOA:O35033" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR005252" /db_xref="InterPro:IPR007085" /db_xref="InterPro:IPR035929" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG13388" /db_xref="UniProtKB/Swiss-Prot:O35033" /translation="MLNNRNVLLCVSGGIAVYKACALTSKLVQAGANVKVIMTESACR FVSPLTFQALSRHEVYTDTFKEQNPSVISHIDAADWADLIIVAPATANVIGKLANGIA DDMLTTTLLAATAPVWIAPAMNVHMYDHPAVKRNISVLYQDGYCFIEPSEGYLACGYV GKGRLEEPENIVKLAEKHFAEETSAPLEGKHVVITAGPTREAIDPVRFFTNKSTGKMG YALAEAAVQLGARVILISGPVSLDQPKGLAEFIPVQSAADMREAVLSVYDASDIVIKT AAVADFTPKTVFDHKMKKQDGGMTLELKRTVDILKELGEKKKEQILVGFAAETQDIEH YARKKLAAKNLDLIVANDVKANGAGFGADTNIVTIFFKDGHKRELPIMSKLDVSFEIL QEIAALSKQTGERS*" /label="coaBC CDS" gene 1468002..1469222 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /label="coaBC gene" S_feature complement(1469061..1469636) /Source="Nicolas_S_feature" /locus_tag="new_1643910_1644485_c" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, B60, LPhT, HiTm, Heat" /AntisenseName="priA" /AntisenseCor="-5.1213364637925501E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S572" CDS 1469219..1471636 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10572298, 11917020, 12682299, 21170359, 22720735, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572298, 11917020, 12682299, 21170359, 22720735, 28527403; Product type f : factor" /codon_start=1 /transl_table=11 /product="primosomal replication factor Y (primosomal protein N')" /protein_id="NP_389453.1" /db_xref="EnsemblGenomes-Gn:BSU15710" /db_xref="EnsemblGenomes-Tr:CAB13444" /db_xref="GOA:P94461" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005259" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11963" /db_xref="UniProtKB/Swiss-Prot:P94461" /translation="MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPR KIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQA MLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGD IDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKI PAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAF EPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVN RFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDE EHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKH RVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFV MCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQ RVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPN VTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQL TKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGA DTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISID MNPYMMM*" /label="priA CDS" gene 1469219..1471636 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /label="priA gene" promotor_-10 complement(1469632..1469650) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1469636) /Source="Nicolas_upshifts" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1469664..1469670) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1471487..1471491 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1471507..1471526 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1471518 /Source="Nicolas_upshifts" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1471663..1472145 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /EC_number="3.5.1.88" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11429456, 16014871, 16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16014871, 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide deformylase" /protein_id="NP_389454.1" /db_xref="EnsemblGenomes-Gn:BSU15720" /db_xref="EnsemblGenomes-Tr:CAB13445" /db_xref="GOA:P94462" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11933" /db_xref="UniProtKB/Swiss-Prot:P94462" /translation="MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDG VGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTR ADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG *" /label="defA CDS" gene 1471663..1472145 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /label="defA gene" CDS 1472150..1473103 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /EC_number="2.1.2.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA formyltransferase" /protein_id="NP_389455.1" /db_xref="EnsemblGenomes-Gn:BSU15730" /db_xref="EnsemblGenomes-Tr:CAB13446" /db_xref="GOA:P94463" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR005793" /db_xref="InterPro:IPR005794" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036477" /db_xref="InterPro:IPR037022" /db_xref="SubtiList:BG11937" /db_xref="UniProtKB/Swiss-Prot:P94463" /translation="MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVL TPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKY GCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETD NVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTG EELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGN ETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN*" /label="fmt CDS" gene 1472150..1473103 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /label="fmt gene" CDS 1473090..1474433 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /EC_number="2.1.1.176" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14656444, 23729652, 27698115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA-binding Sun protein; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent" /protein_id="NP_389456.1" /db_xref="EnsemblGenomes-Gn:BSU15740" /db_xref="EnsemblGenomes-Tr:CAB13447" /db_xref="GOA:P94464" /db_xref="InterPro:IPR001678" /db_xref="InterPro:IPR004573" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR018314" /db_xref="InterPro:IPR023267" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG12253" /db_xref="UniProtKB/Swiss-Prot:P94464" /translation="MKKTSVRDIALEALIKLEQNQAYSNLLLKSVIKSNELSDQNRGL LTELVYGTLQNKIALDYMLKPFINKPQKVKPWVIQLLRLSLYQMEYLEKIPDRAAIHE AVEIAKIRGHKGIASFVNGVLRSIQREGVPSFDAIEDPVRRLATETSHPEWLVKEWAD AYGFEAAEKICRIHLIPPKQTLRVNQMKADRAELLDQMAAEGIEVEKGDLAEDAVKLL KGTIAGTHFFQNGEVSIQDESSMLVARALDPKSDETVLDACAAPGGKSAHIAELMKNK GSVTSLDLHKHKVKLIKEAADRLGLTIIHAETMDARKAGETFENEQFDRILVDAPCSG FGVIRRKPDMKYTKKPDDSARLAEIQLSILREIAPLVKKGGTLVYSTCTMDRTENDEV IHAFIQEHPDFEPDLSLEKRLPEKVRPFVRDGRLQILPHYFGTDGFFICSMRKKG*" /label="rsmB CDS" gene 1473090..1474433 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /label="rsmB gene" CDS 1474437..1475528 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /EC_number="2.1.1.192" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8973346, 18307109, 20184321, 21368151, 22891362, 27081063, 27902775; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2A2503 methyltransferase and tRNA A37 C2 methyltransferase" /protein_id="NP_389457.1" /db_xref="EnsemblGenomes-Gn:BSU15750" /db_xref="EnsemblGenomes-Tr:CAB13448" /db_xref="GOA:O34617" /db_xref="InterPro:IPR004383" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR027492" /db_xref="SubtiList:BG13389" /db_xref="UniProtKB/Swiss-Prot:O34617" /translation="MAELNKTKVRKELRTERPSIYSFELDEIKQWLTDNGEKPFRAAQ IFEWLYEKRVSSFEDMTNLSKDLREKLNTRFVLTTLKTAVKQTSQDGTMKFLFELHDG YTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQKAL DETDERVSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYE FADQQMQINFAISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGRRISFEYGL FGGVNDQVEHAEELADLLEGVKCHVNLIPVNYVPERDYVRTPRDQIFAFEKTLKSRGV NVTIRREQGHDIDAACGQLRAKERQDETR*" /label="rlmN CDS" gene 1474437..1475528 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /label="rlmN gene" CDS 1475535..1476299 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /EC_number="3.1.3.16" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 17693724, 22720735, 24390483, 25012659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 17693724, 22720735, 24390483, 25012659; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="multitarget phosphorylated protein phosphatase" /protein_id="NP_389458.1" /db_xref="EnsemblGenomes-Gn:BSU15760" /db_xref="EnsemblGenomes-Tr:CAB13449" /db_xref="GOA:O34779" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR015655" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG13390" /db_xref="UniProtKB/Swiss-Prot:O34779" /translation="MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAG DVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGT TIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQE KVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC*" /label="prpC CDS" gene 1475535..1476299 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /label="prpC gene" downshifts 1475588 /Source="Nicolas_upshifts" /id="D878" /incds=0 /nref=5 /ntot=126 /MaxReadThrough="6.12318" /MaxDrop="3.8594" /score="-7.80200272" /energy="-10" /TU="U1295,U1298" /idTUdmin="U1300" /TUdmin="-4708" /isTUend="FALSE" /label="downshifts" CDS 1476293..1478239 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /EC_number="2.7.11.1" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 18984160, 24390483, 25845974, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 18984160, 24390483, 25845974, 26102633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine/threonine kinase" /protein_id="NP_389459.1" /db_xref="EnsemblGenomes-Gn:BSU15770" /db_xref="EnsemblGenomes-Tr:CAB13450" /db_xref="GOA:O34507" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13391" /db_xref="UniProtKB/Swiss-Prot:O34507" /translation="MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRF DYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA NGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALS STTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSI ALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRL NEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLL TICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEIS DEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQG FNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKE AASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPA KTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQ KGYYQVMVNNKVVSYKTIEYPKDE*" /label="prkC CDS" gene 1476293..1478239 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /label="prkC gene" promotor_-35 1478148..1478154 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1478168..1478186 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1478184 /Source="Nicolas_upshifts" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1478254..1479150 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome biogenesis" /protein_id="NP_389460.1" /db_xref="EnsemblGenomes-Gn:BSU15780" /db_xref="EnsemblGenomes-Tr:CAB13451" /db_xref="GOA:O34530" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="InterPro:IPR031944" /db_xref="PDB:1T9H" /db_xref="SubtiList:BG13392" /db_xref="UniProtKB/Swiss-Prot:O34530" /translation="MPEGKIIKALSGFYYVLDESEDSDKVIQCRGRGIFRKNKITPLV GDYVVYQAENDKEGYLMEIKERTNELIRPPICNVDQAVLVFSAVQPSFSTALLDRFLV LVEANDIQPIICITKMDLIEDQDTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIP HFQDKTTVFAGQSGVGKSSLLNAISPELGLRTNEISEHLGRGKHTTRHVELIHTSGGL VADTPGFSSLEFTDIEEEELGYTFPDIREKSSSCKFRGCLHLKEPKCAVKQAVEDGEL KQYRYDHYVEFMTEIKDRKPRY*" /label="rsgA CDS" gene 1478254..1479150 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /label="rsgA gene" CDS 1479155..1479808 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /EC_number="5.1.3.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 973353, 15755726, 16489742, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribulose-5-phosphate 3-epimerase" /protein_id="NP_389461.1" /db_xref="EnsemblGenomes-Gn:BSU15790" /db_xref="EnsemblGenomes-Tr:CAB13452" /db_xref="GOA:O34557" /db_xref="InterPro:IPR000056" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR026019" /db_xref="SubtiList:BG13393" /db_xref="UniProtKB/Swiss-Prot:O34557" /translation="MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNI TIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQL IKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKR MADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK* " /label="rpe CDS" gene 1479155..1479808 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /label="rpe gene" promotor_-35 1479806..1479815 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-35" promotor_-10 1479829..1479848 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-10" upshifts 1479834 /Source="Nicolas_upshifts" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="upshifts" CDS 1479881..1480525 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /EC_number="2.7.6.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14567704, 15150256, 16291685, 19490098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine pyrophosphokinase" /protein_id="NP_389462.1" /db_xref="EnsemblGenomes-Gn:BSU15800" /db_xref="EnsemblGenomes-Tr:CAB13453" /db_xref="GOA:O34664" /db_xref="InterPro:IPR006282" /db_xref="InterPro:IPR007371" /db_xref="InterPro:IPR007373" /db_xref="InterPro:IPR036371" /db_xref="InterPro:IPR036759" /db_xref="PDB:3LM8" /db_xref="SubtiList:BG13394" /db_xref="UniProtKB/Swiss-Prot:O34664" /translation="MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGII PVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGI TGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPF SEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD*" /label="thiN CDS" gene 1479881..1480525 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /label="thiN gene" promotor_-35 1480286..1480292 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-35" upshifts 1480303 /Source="Nicolas_upshifts" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="upshifts" promotor_-10 1480307..1480325 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-10" promotor_-35 1480416..1480421 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1480437..1480455 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1480450 /Source="Nicolas_upshifts" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1480526..1480596 /Source="Nicolas_S_feature" /locus_tag="new_1655375_1655445" /HighExp="S4, S5, S7, S8, S6, S3, B36, G/S, B60, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigB, SigA, SigA" /TUshortPSig="0.977, 0.548, 0.973, 1, 0.994" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S573" CDS 1480597..1480677 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for normal spore cortex and coatsynthesis (stage V sporulation)" /protein_id="NP_389463.1" /db_xref="EnsemblGenomes-Gn:BSU15810" /db_xref="EnsemblGenomes-Tr:CAB13454" /db_xref="GOA:P37817" /db_xref="InterPro:IPR012609" /db_xref="PDB:2MVH" /db_xref="PDB:2MVJ" /db_xref="SubtiList:BG10776" /db_xref="UniProtKB/Swiss-Prot:P37817" /translation="MKFYTIKLPKFLGGIVRAMLGSFRKD*" /label="spoVM CDS" gene 1480597..1480677 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /label="spoVM gene" downshifts 1480692 /Source="Nicolas_upshifts" /id="D879" /incds=0 /nref=178 /ntot=258 /MaxReadThrough="4.05442" /MaxDrop="7.745" /score="7.47691609" /energy="-16.9" /TU="U1301,U1302" /idTUdmin="U1295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1480737..1481109 /Source="Nicolas_S_feature" /locus_tag="new_1655586_1655958" /HighExp="S4, S5, T5.0H, S3, S6, S8, S7, T4.0H, LoTm, T3.30H" /AntisenseName="rpmB" /AntisenseCor="-0.40376097579549802" /AntisenseRegPval="-11.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.977, 0.548" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S574" CDS complement(1480750..1480938) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8722036; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L28" /protein_id="NP_389464.1" /db_xref="EnsemblGenomes-Gn:BSU15820" /db_xref="EnsemblGenomes-Tr:CAB13455" /db_xref="GOA:P37807" /db_xref="InterPro:IPR001383" /db_xref="InterPro:IPR026569" /db_xref="InterPro:IPR034704" /db_xref="InterPro:IPR037147" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10777" /db_xref="UniProtKB/Swiss-Prot:P37807" /translation="MARKCVITGKKTTAGNNRSHAMNASKRTWGANLQKVRILVNGKP KKVYVSARALKSGKVERV*" /label="rpmB CDS" gene complement(1480750..1480938) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /label="rpmB gene" downshifts complement(1480766) /Source="Nicolas_upshifts" /id="D880" /incds=0 /nref=216 /ntot=298 /MaxReadThrough="2.59598" /MaxDrop="7.48719" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" downshifts complement(1480812) /Source="Nicolas_upshifts" /id="D881" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="7.6779" /MaxDrop="3.1786" /score="15.2403969" /energy="-14.3" /TU="U1303" /idTUdmin="U1303" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(1480939..1481031) /Source="Nicolas_S_feature" /locus_tag="new_1655788_1655880_c" /HighExp="HPh, LPh, HiOs, LBGexp, aero, G180, GM 15, dia0, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S575" promotor_-10 complement(1481013..1481032) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1481031) /Source="Nicolas_upshifts" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1481048..1481051) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1481082..1481089 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1481104..1481122 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1481111 /Source="Nicolas_upshifts" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" promotor_-35 1481150..1481153 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1481168..1481187 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1481176 /Source="Nicolas_upshifts" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" CDS 1481215..1481577 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 17114254, 24178028, 28579978; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor involved in malonyl-CoA synthesis" /protein_id="NP_389465.1" /db_xref="EnsemblGenomes-Gn:BSU15830" /db_xref="EnsemblGenomes-Tr:CAB13456" /db_xref="InterPro:IPR005531" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG13395" /db_xref="UniProtKB/Swiss-Prot:O34318" /translation="MSIELRTKYGQIDISNEVIAMVAGGAAVDCYGIVGMASKNQIKD GLTEILRKENFSRGVQVRQEGEQIHIDMYIIVSYGTKISEVAHNVQTKVKYTVNQTIG LAVDSVNIYVQGVRVTNP*" /label="yloU CDS" gene 1481215..1481577 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /label="yloU gene" downshifts complement(1481428) /Source="Nicolas_upshifts" /id="D882" /incds=1 /nref=1 /ntot=143 /MaxReadThrough="1.75412" /MaxDrop="2.71497" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1481593..1483254 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16647083, 22333191, 22517742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme structurally related to dihydroxyacetone/glyceraldehyde kinase" /protein_id="NP_389466.1" /db_xref="EnsemblGenomes-Gn:BSU15840" /db_xref="EnsemblGenomes-Tr:CAB13457" /db_xref="GOA:O34751" /db_xref="InterPro:IPR004007" /db_xref="InterPro:IPR019986" /db_xref="InterPro:IPR033470" /db_xref="InterPro:IPR036117" /db_xref="SubtiList:BG13396" /db_xref="UniProtKB/Swiss-Prot:O34751" /translation="MSIRTLDGRTFAEMILAGAQNLSQNASAVDALNVFPVPDGDTGT NMNLSMTSGAREVEQMDTDDIGKVGSALSKGLLMGARGNSGVILSQLFRGFSKNIETK KEINALEFAAALQAGVDMAYKAVMKPVEGTILTVAKDAAKKAMILAEKETDITALMTA VTEEAEASLNRTPELLPVLKEVGVVDSGGKGLLCVYEGFLASLKGETVPQKAVLPSLD DMVSAEHHKSAQSMMNTEDIEFGFCTEVMVRLDQTKREFDEGTFRQDLSQFGDSLLVI ADESLAKVHIHAEEPGNVLNYAQHYGELIKIKIENMREQHTSIISQESKPADNETPPA KQPYGIVTVAMGEGIADLFKSIGASVVIEGGQTMNPSTEDIVDAVKSVNADTVFILPN NSNIIMAANQAASVVDEQVFVIPAKTVPQGMSALLAFNPDQEAEANEANMLSAIQQVK SGQVTFSVRDTHIDGKDIKKGDFMGILNGTIIGTSENQLSAAKMLLSEMIGEDDEIVT ILYGEDASQEEAEQLEAFLSEKYEEIEVEIHNGKQPLYSYIVSAE*" /label="yloV CDS" gene 1481593..1483254 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /label="yloV gene" S_feature 1483255..1483344 /Source="Nicolas_S_feature" /locus_tag="new_1658104_1658193" /HighExp="G135, G180, G150, LBGexp, Oxctl, Paraq, dia0, LPh, Lbexp, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37023200000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.991, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S576" promotor_-35 1483317..1483324 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-35" promotor_-10 1483338..1483357 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-10" upshifts 1483346 /Source="Nicolas_upshifts" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="upshifts" CDS 1483393..1484055 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8385012, 9244285, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385012, 9244285, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (beta chain)" /protein_id="NP_389467.1" /db_xref="EnsemblGenomes-Gn:BSU15850" /db_xref="EnsemblGenomes-Tr:CAB13458" /db_xref="GOA:O34635" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004643" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="SubtiList:BG13397" /db_xref="UniProtKB/Swiss-Prot:O34635" /translation="MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERII VSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPV HPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTI AGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKI AD*" /label="sdaAB CDS" gene 1483393..1484055 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /label="sdaAB gene" CDS 1484081..1484983 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2504697, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2504697, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (alpha chain)" /protein_id="NP_389468.1" /db_xref="EnsemblGenomes-Gn:BSU15860" /db_xref="EnsemblGenomes-Tr:CAB13459" /db_xref="GOA:O34607" /db_xref="InterPro:IPR004642" /db_xref="InterPro:IPR005130" /db_xref="SubtiList:BG13398" /db_xref="UniProtKB/Swiss-Prot:O34607" /translation="MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDH NLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEV NAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASIS GAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVP CVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAAT PTGRELEKKIFGGALGSRETTSAN*" /label="sdaAA CDS" gene 1484081..1484983 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /label="sdaAA gene" CDS 1484961..1487009 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branch migrating ATP-dependent DNA helicase involved in DNA recombination and repair" /protein_id="NP_389469.1" /db_xref="EnsemblGenomes-Gn:BSU15870" /db_xref="EnsemblGenomes-Tr:CAB13460" /db_xref="GOA:O34942" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR004609" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033454" /db_xref="SubtiList:BG13399" /db_xref="UniProtKB/Swiss-Prot:O34942" /translation="MKQHQQTSIANIKGIGPETEKTLNELGIYDISDLLNYFPYRYDD YELRDLEEVKHDERVTVEGKVHSEPSLTYYGKKRNRLTFRLLVGHYLITAVCFNRPYL KKKLSLGSVVTVSGKWDKHRQTISVQELKNGPHQEDKSIEPVYSVKENVTVKMMRRFI QQALTQYADSLPDPLPEKLRKSYKLPDYYQALKAMHQPETREALKLARRRFVYEEFLL FQLKMQAFRKAEREQTQGIRQRFSNEELMRFIKSLPFPLTNAQSRVLREITADMSSPY RMNRLLQGDVGSGKTAVAAIALYAAILSGYQGALMVPTEILAEQHADSLVSLFEKWDV SVALLTSSVKGKRRKELLERLAAGEIDILVGTHALIQDEVEFKALSLVITDEQHRFGV EQRKKLRNKGQDPDVLFMTATPIPRTLAITVFGEMDVSVIDEMPAGRKRIETYWVKHD MLDRILAFVEKELKQGRQAYIICPLIEESDKLDVQNAIDVYNMLSDIFRGKWNVGLMH GKLHSDEKDQVMREFSANHCQILVSTTVVEVGVNVPNATIMVIYDADRFGLSQLHQLR GRVGRGEHQSFCILMADPKSETGKERMRIMSETNDGFELSEKDLELRGPGDFFGKKQS GMPEFKVADMVHDYRALETARQDAANLVASDAFWKEPEYAVLRDELLKSGVMDGEKLS *" /label="recG CDS" gene 1484961..1487009 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /label="recG gene" promotor_-35 1487045..1487052 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1487067..1487086 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1487073 /Source="Nicolas_upshifts" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1487118..1487684 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12737802, 17962296, 20201588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12737802, 17962296, 20201588, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription factor controlling fatty acid and phospholipid metabolism (FapR-malonyl-Coa)" /protein_id="NP_389470.1" /db_xref="EnsemblGenomes-Gn:BSU15880" /db_xref="EnsemblGenomes-Tr:CAB13461" /db_xref="GOA:O34835" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR017275" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="PDB:2F3X" /db_xref="PDB:2F41" /db_xref="SubtiList:BG13400" /db_xref="UniProtKB/Swiss-Prot:O34835" /translation="MRRNKRERQELLQQTIQATPFITDEELAGKFGVSIQTIRLDRLE LSIPELRERIKNVAEKTLEDEVKSLSLDEVIGEIIDLELDDQAISILEIKQEHVFSRN QIARGHHLFAQANSLAVAVIDDELALTASADIRFTRQVKQGERVVAKAKVTAVEKEKG RTVVEVNSYVGEEIVFSGRFDMYRSKHS*" /label="fapR CDS" gene 1487118..1487684 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /label="fapR gene" CDS 1487698..1488699 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphate:acyl-ACP acyltransferase" /protein_id="NP_389471.1" /db_xref="EnsemblGenomes-Gn:BSU15890" /db_xref="EnsemblGenomes-Tr:CAB13462" /db_xref="GOA:P71018" /db_xref="InterPro:IPR003664" /db_xref="InterPro:IPR012281" /db_xref="PDB:1VI1" /db_xref="SubtiList:BG11843" /db_xref="UniProtKB/Swiss-Prot:P71018" /translation="MRIAVDAMGGDHAPKAVIDGVIKGIEAFDDLHITLVGDKTTIES HLTTTSDRITVLHADEVIEPTDEPVRAVRRKKNSSMVLMAQEVAENRADACISAGNTG ALMTAGLFIVGRIKGIDRPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSV YSQQVRGVTSPRVGLLNVGTEDKKGNELTKQTFQILKETANINFIGNVEARDLLDDVA DVVVTDGFTGNVTLKTLEGSALSIFKMMRDVMTSTLTSKLAAAVLKPKLKEMKMKMEY SNYGGASLFGLKAPVIKAHGSSDSNAVFHAIRQAREMVSQNVAALIQEEVKEEKTDE* " /label="plsX CDS" gene 1487698..1488699 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /label="plsX gene" CDS 1488718..1489671 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /EC_number="2.3.1.39" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586097, 19850612" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586097, 19850612; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl CoA:acyl carrier protein transacylase" /protein_id="NP_389472.1" /db_xref="EnsemblGenomes-Gn:BSU15900" /db_xref="EnsemblGenomes-Tr:CAB13463" /db_xref="GOA:P71019" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="SubtiList:BG11836" /db_xref="UniProtKB/Swiss-Prot:P71019" /translation="MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKL SSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAG ALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLAN LNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDA CDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIG PGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA*" /label="fabD CDS" gene 1488718..1489671 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /label="fabD gene" CDS 1489664..1490404 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /EC_number="1.1.1.100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12655455, 12682299, 19850612, 28126742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12655455, 12682299, 19850612, 28126742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein reductase" /protein_id="NP_389473.1" /db_xref="EnsemblGenomes-Gn:BSU15910" /db_xref="EnsemblGenomes-Tr:CAB13464" /db_xref="GOA:P51831" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11535" /db_xref="UniProtKB/Swiss-Prot:P51831" /translation="MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANE VVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMK EDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAG VIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDV SSVVTFLASEGARYMTGQTLHIDGGMVM*" /label="fabG CDS" gene 1489664..1490404 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /label="fabG gene" promotor_-35 1490435..1490439 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1490455..1490474 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1490460 /Source="Nicolas_upshifts" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1490488..1490721 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 19850612, 27467752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 19850612, 27467752; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="NP_389474.1" /db_xref="EnsemblGenomes-Gn:BSU15920" /db_xref="EnsemblGenomes-Tr:CAB13465" /db_xref="GOA:P80643" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:1F80" /db_xref="PDB:1HY8" /db_xref="PDB:2X2B" /db_xref="SubtiList:BG11536" /db_xref="UniProtKB/Swiss-Prot:P80643" /translation="MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELV MELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ*" /label="acpA CDS" gene 1490488..1490721 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /label="acpA gene" downshifts 1490702 /Source="Nicolas_upshifts" /id="D883" /incds=0 /nref=22 /ntot=197 /MaxReadThrough="8.12206" /MaxDrop="4.1545" /score="-8.42930766" /energy="-17.4" /TU="U1306,U1307,U1308" /idTUdmin="U1306" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" promotor_no_box 1490730..1490830 /Source="Nicolas_upshift_promotors" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 1490790..1490860 /Source="Nicolas_S_feature" /locus_tag="new_1665639_1665709" /HighExp="LBGstat, dia5, Cold, LBGtran, C30, Diami, G135, LBGexp, G/S, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA, SigA" /TUshortPSig="0.031, 1, 1, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="0.991, 0.991" /label="S577" upshifts 1490790 /Source="Nicolas_upshifts" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1490861..1491610 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /EC_number="3.1.26.3" /experiment="publication(s) with functional evidences, PMID:11123676, 12682299, 16179796, 22412379, 23300471, 26883633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11123676, 12682299, 16179796, 22412379, 23300471, 26883633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="NP_389475.1" /db_xref="EnsemblGenomes-Gn:BSU15930" /db_xref="EnsemblGenomes-Tr:CAB13466" /db_xref="GOA:P51833" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR011907" /db_xref="InterPro:IPR014720" /db_xref="InterPro:IPR036389" /db_xref="SubtiList:BG11537" /db_xref="UniProtKB/Swiss-Prot:P51833" /translation="MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHS SYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSL VSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEP LGVGNGRSKKEAEQHAAQEALAKLQKHHTKQ*" /label="rnc CDS" gene 1490861..1491610 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /label="rnc gene" downshifts 1491582 /Source="Nicolas_upshifts" /id="D884" /incds=0 /nref=78 /ntot=211 /MaxReadThrough="6.42554" /MaxDrop="5.70849" /score="-8.42930766" /energy="-17.4" /TU="U1307,U1308,U1309" /idTUdmin="U1306" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1491652..1491658 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1491670..1491689 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1491692 /Source="Nicolas_upshifts" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1491711..1495271 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation SMC ATPase" /protein_id="NP_389476.2" /db_xref="EnsemblGenomes-Gn:BSU15940" /db_xref="EnsemblGenomes-Tr:CAB13467" /db_xref="GOA:P51834" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /db_xref="InterPro:IPR024704" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036277" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5NMO" /db_xref="PDB:5NNV" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG11538" /db_xref="UniProtKB/Swiss-Prot:P51834" /translation="MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAI RWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTR RVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSI FEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEK KKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKI QALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETV LKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQ ASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHS QVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVK EVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQ NSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTV LITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDV TKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQV AEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQK QTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSF LTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMK RLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKR VKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMT KRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNL LSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIV ITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ*" /label="smc CDS" gene 1491711..1495271 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /label="smc gene" S_feature complement(1495205..1496275) /Source="Nicolas_S_feature" /locus_tag="new_1670054_1671124_c" /HighExp="Cold, C30, Gly, T0.30H, Pyr, T-4.40H, G135, Lbstat, Fru, T-5.40H" /AntisenseName="ftsY" /AntisenseCor="-3.7172405649441298E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S578" CDS 1495291..1496280 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal recognition particle (docking protein)" /protein_id="NP_389477.1" /db_xref="EnsemblGenomes-Gn:BSU15950" /db_xref="EnsemblGenomes-Tr:CAB13468" /db_xref="GOA:P51835" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036225" /db_xref="SubtiList:BG11539" /db_xref="UniProtKB/Swiss-Prot:P51835" /translation="MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRY RKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEI YNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFR AGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKV NLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLD GTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD*" /label="ftsY CDS" gene 1495291..1496280 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /label="ftsY gene" downshifts 1496267 /Source="Nicolas_upshifts" /id="D885" /incds=0 /nref=220 /ntot=261 /MaxReadThrough="2.98458" /MaxDrop="6.84303" /score="49.5808683" /energy="-14.4" /TU="NA" /idTUdmin="U1307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1496317..1496802) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535, 22287527" /codon_start=1 /transl_table=11 /product="conserved exported protein of unknown function" /protein_id="NP_389478.1" /db_xref="EnsemblGenomes-Gn:BSU15960" /db_xref="EnsemblGenomes-Tr:CAB13469" /db_xref="GOA:O31737" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="SubtiList:BG13401" /db_xref="UniProtKB/Swiss-Prot:O31737" /translation="MKKIGLLFMLCLAALFTIGFPAQQADAAEAPYKASITNISTDGG VYGKINYGQGQYWRVKYNITVSGKLLDQNGQPVPNAPVRFEADTKVGNTTQTASGTTD ANGTFEVPMYLGPAAGYYTYYTSVSVHYYDIIPFRVFSGESRLVSTDNSLYHFAYQVR R*" /label="ylqB CDS" gene complement(1496317..1496802) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /label="ylqB gene" downshifts complement(1496320) /Source="Nicolas_upshifts" /id="D886" /incds=0 /nref=139 /ntot=244 /MaxReadThrough="6.77251" /MaxDrop="6.10895" /score="32.8428224" /energy="-14.4" /TU="U1311" /idTUdmin="U1311" /TUdmin="-1076" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1496824..1496842) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1496840) /Source="Nicolas_upshifts" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1496856..1496863) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1496905..1496911 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1496926..1496945 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1496928 /Source="Nicolas_upshifts" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1496979..1497311 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11274114, 24659773; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the signal recognition particle (SRP) protein-targeting pathway" /protein_id="NP_389479.1" /db_xref="EnsemblGenomes-Gn:BSU15970" /db_xref="EnsemblGenomes-Tr:CAB13470" /db_xref="GOA:P37104" /db_xref="InterPro:IPR007394" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10829" /db_xref="UniProtKB/Swiss-Prot:P37104" /translation="MSLEKTTRMNYLFDFYQSLLTSKQKSYMSLYYLDDFSLGEIAEE YEVSRQAVYDNIKRTEAMLEQYEEKLLLLKKFQERKEMFNKLKELASGSKEEEEITAL IEALEKLD*" /label="ylxM CDS" gene 1496979..1497311 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /label="ylxM gene" downshifts complement(1496982) /Source="Nicolas_upshifts" /id="D887" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="1.40385" /MaxDrop="4.6092" /score="32.8428224" /energy="-14.4" /TU="NA" /idTUdmin="U1311" /TUdmin="-1738" /isTUend="FALSE" /label="downshifts" CDS 1497325..1498665 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal recognition particle-like (SRP) GTPase" /protein_id="NP_389480.1" /db_xref="EnsemblGenomes-Gn:BSU15980" /db_xref="EnsemblGenomes-Tr:CAB13471" /db_xref="GOA:P37105" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004125" /db_xref="InterPro:IPR004780" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR022941" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036891" /db_xref="PDB:4UE4" /db_xref="SubtiList:BG10830" /db_xref="UniProtKB/Swiss-Prot:P37105" /translation="MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADV NFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPT VIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEI FLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGL GEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDF LEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPD IINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM*" /label="ffh CDS" gene 1497325..1498665 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /label="ffh gene" S_feature 1498666..1498770 /Source="Nicolas_S_feature" /locus_tag="new_1673515_1673619" /HighExp="Cold, G135, C30, G180, LPhT, HPh, Paraq, LPh, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S579" CDS 1498771..1499043 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6419023, 12682299, 20034956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6419023, 12682299, 20034956; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S16 (BS17)" /protein_id="NP_389481.1" /db_xref="EnsemblGenomes-Gn:BSU15990" /db_xref="EnsemblGenomes-Tr:CAB13472" /db_xref="GOA:P21474" /db_xref="InterPro:IPR000307" /db_xref="InterPro:IPR020592" /db_xref="InterPro:IPR023803" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10831" /db_xref="UniProtKB/Swiss-Prot:P21474" /translation="MAVKIRLKRMGAKKSPFYRIVVADSRSPRDGRFIETVGTYNPVA KPAEVKIDEELALKWLQTGAKPSDTVRNLFSSQGIMEKFHNAKQGK*" /label="rpsP CDS" gene 1498771..1499043 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /label="rpsP gene" CDS 1499043..1499288 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735, 26483775; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_389482.1" /db_xref="EnsemblGenomes-Gn:BSU16000" /db_xref="EnsemblGenomes-Tr:CAB13473" /db_xref="GOA:O31738" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020627" /db_xref="SubtiList:BG13402" /db_xref="UniProtKB/Swiss-Prot:O31738" /translation="MTDQHLEDLIVHIVTPLVDHPDDIRVIREETDQKIALRLSVHKS DTGKVIGKQGRTAKAIRTAVFAAGVQSSKKVQFEIFD*" /label="ylqC CDS" gene 1499043..1499288 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /label="ylqC gene" downshifts 1499260 /Source="Nicolas_upshifts" /id="D888" /incds=0 /nref=41 /ntot=178 /MaxReadThrough="6.57974" /MaxDrop="4.803" /score="-7.01631592" /energy="-5.6" /TU="U1312" /idTUdmin="U1312" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" S_feature 1499305..1499409 /Source="Nicolas_S_feature" /locus_tag="new_1674154_1674258" /HighExp="G180, Oxctl, G150, G135, Paraq, LBGexp, H2O2, HPh, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S580" CDS 1499410..1499796 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389483.1" /db_xref="EnsemblGenomes-Gn:BSU16010" /db_xref="EnsemblGenomes-Tr:CAB13474" /db_xref="InterPro:IPR021297" /db_xref="SubtiList:BG13403" /db_xref="UniProtKB/Swiss-Prot:O31739" /translation="MQIIHRVAVMQVLTERSKEKLLASFAEKKQMLERECSQLYFQLR KHEKEQQNPNMIEQFKKAIEKRKDDIKIIDFQIAQVHTLPLGSELKEKEVDALLTIEA GDDWHEKTAANTIVIKDGKVIEIRQR*" /label="ylqD CDS" gene 1499410..1499796 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /label="ylqD gene" CDS 1499801..1500325 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15496525, 16014871, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="16S rRNA processing protein" /protein_id="NP_389484.1" /db_xref="EnsemblGenomes-Gn:BSU16020" /db_xref="EnsemblGenomes-Tr:CAB13475" /db_xref="GOA:O31740" /db_xref="InterPro:IPR002676" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR011961" /db_xref="InterPro:IPR027275" /db_xref="InterPro:IPR036976" /db_xref="SubtiList:BG13404" /db_xref="UniProtKB/Swiss-Prot:O31740" /translation="MTKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFM DGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNEVEELKNAIIKVPEEELGELNEGEFY FHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESVVKHIDVRE KKIEIELMEGLIDE*" /label="rimM CDS" gene 1499801..1500325 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /label="rimM gene" CDS 1500322..1501053 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /EC_number="2.1.1.228" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094308, 11532950, 12682299, 12773376, 15060037, 27881678, 28601227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(m1G37)methyltransferase" /protein_id="NP_389485.1" /db_xref="EnsemblGenomes-Gn:BSU16030" /db_xref="EnsemblGenomes-Tr:CAB13476" /db_xref="GOA:O31741" /db_xref="InterPro:IPR002649" /db_xref="InterPro:IPR016009" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG12687" /db_xref="UniProtKB/Swiss-Prot:O31741" /translation="MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDN KHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQL AKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVL GKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYL RRPDLLKDHPLTEQQRKWISEWEKE*" /label="trmD CDS" gene 1500322..1501053 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /label="trmD gene" promotor_-35 1501059..1501066 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1501080..1501099 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1501084 /Source="Nicolas_upshifts" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" misc_RNA 1501132..1501173 /locus_tag="BSU_misc_RNA_30" /product="L19_leader" /label="L19 leader RNA" gene 1501132..1501173 /locus_tag="BSU_misc_RNA_30" /label="gene" CDS 1501193..1501540 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16272117, 27477481; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L19" /protein_id="NP_389486.2" /db_xref="EnsemblGenomes-Gn:BSU16040" /db_xref="EnsemblGenomes-Tr:CAB13477" /db_xref="GOA:O31742" /db_xref="InterPro:IPR001857" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR018257" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12667" /db_xref="UniProtKB/Swiss-Prot:O31742" /translation="MQKLIEDITKEQLRTDLPAFRPGDTLRVHVKVVEGNRERIQIFE GVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIAKIEVVRYGKVRRAKLYYLRE LRGKAARIKEIRR*" /label="rplS CDS" gene 1501193..1501540 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /label="rplS gene" downshifts 1501542 /Source="Nicolas_upshifts" /id="D889" /incds=0 /nref=212 /ntot=274 /MaxReadThrough="6.00308" /MaxDrop="9.06015" /score="23.9942041" /energy="-12.6" /TU="U1313" /idTUdmin="U1312" /TUdmin=478 /isTUend="FALSE" /label="downshifts" promotor_-35 1501595..1501601 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1501614..1501682 /Source="Nicolas_S_feature" /locus_tag="new_1676463_1676531" /HighExp="Oxctl, G180, Paraq, G135, H2O2, LBGstat, dia15, G150, HPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.149563" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S581" upshifts 1501614 /Source="Nicolas_upshifts" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1501615..1501634 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1501683..1502531 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome biogenesis GTPase A" /protein_id="NP_389487.1" /db_xref="EnsemblGenomes-Gn:BSU16050" /db_xref="EnsemblGenomes-Tr:CAB13478" /db_xref="GOA:O31743" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016478" /db_xref="InterPro:IPR019991" /db_xref="InterPro:IPR023179" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="PDB:1PUJ" /db_xref="SubtiList:BG13405" /db_xref="UniProtKB/Swiss-Prot:O31743" /translation="MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMI EDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKE ILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQW VKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYP ERLKERYGLDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLS FEQPTM*" /label="rbgA CDS" gene 1501683..1502531 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /label="rbgA gene" promotor_-35 1502552..1502559 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1502572..1502590 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1502582 /Source="Nicolas_upshifts" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1502602..1503369 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /EC_number="3.1.26.4" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10094689, 12475934, 23882084, 23937561, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094689, 12475934, 23882084, 23937561, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HII" /protein_id="NP_389488.1" /db_xref="EnsemblGenomes-Gn:BSU16060" /db_xref="EnsemblGenomes-Tr:CAB13479" /db_xref="GOA:O31744" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR022898" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12666" /db_xref="UniProtKB/Swiss-Prot:O31744" /translation="MNTLTVKDIKDRLQEVKDAQDPFIAQCENDPRKSVQTLVEQWLK KQAKEKALKEQWVNMTSYERLARNKGFRLIAGVDEVGRGPLAGPVVASAVILPEECEI LGLTDSKKLSEKKREEYYELIMKEALAVGIGIVEATVIDEINIYEASKMAMVKAIQDL SDTPDYLLVDAMTLPLDTAQASIIKGDAKSVSIAAGACIAKVTRDRMMSAYAETYPMY GFEKNKGYGTKEHLEALAAYGPTELHRKTFAPVQSFR*" /label="rnhB CDS" gene 1502602..1503369 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /label="rnhB gene" CDS 1503401..1505131 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389489.1" /db_xref="EnsemblGenomes-Gn:BSU16070" /db_xref="EnsemblGenomes-Tr:CAB13480" /db_xref="SubtiList:BG13406" /db_xref="UniProtKB/Swiss-Prot:O31745" /translation="MNIRNDVQKALQHLFGRTAVPQETSKVNEALNGEKRLLLGKVLR LLGDQHALIQVGNQTVQGKLETQLRPQAYYWFSYEKKTAEQTGRLQVVQSFDQNPKTI QDAAGKLLNAISVKTSNAALMMTGAMLKSKTPVTENDIKTAVRWMDTLPSQDTKKAVE TVLFALKRDLPIHSEILNGVHAVKSPVPLHQHVSQLLQAIDQNPQQSQMMSKLKEAVT VLLNSEIDVHAERLIDKLISLTDNTKAPSPTNTAGSRELSTPAGSPGKASLPIANHTA EQGSIQEEPVKTAADIPIKEARQLLVKLTESAEKNSLQIVKEAANWIKAAASSGDSKS LAASAVLQAAQVTDQEAEVFLKAVQQTAPHLADKADVLSFLSKVKTAIGARDEVAFIK AFEQGSAVTSGEMQSIKLALSALRASHEVAEPVKQEADQLFHKLNGQLFMQQDHPSYS QIVMSFPMFSKSGVQDMTVLFKGKKEADGKLDPSHCRLLFLLQLDTLKETVVDCLVQQ KVMTITIETDFELQAAIDPMVPALKQGLKEMGYSLSGVNAKKRVHTEEKASIDQYITS ISDQEVDVKI*" /label="ylqG CDS" gene 1503401..1505131 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /label="ylqG gene" upshifts complement(1504638) /Source="Nicolas_upshifts" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1504639..1504658) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1504673..1504680) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1505128..1505409 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative flagellar biosynthesis protein" /protein_id="NP_389490.1" /db_xref="EnsemblGenomes-Gn:BSU16080" /db_xref="EnsemblGenomes-Tr:CAB13481" /db_xref="GOA:O34867" /db_xref="InterPro:IPR004683" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13407" /db_xref="UniProtKB/Swiss-Prot:O34867" /translation="MKEQTPIRKAVALHYDEQKDKAPRVIATGKGHVADNIIKEAKKA GVPIQEDRTLVELMRHLTVDDQIPEALYETVAEIFSFIYKLDESVKNKK*" /label="ylqH CDS" gene 1505128..1505409 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /label="ylqH gene" downshifts 1505241 /Source="Nicolas_upshifts" /id="D890" /incds=1 /nref=7 /ntot=136 /MaxReadThrough="4.03339" /MaxDrop="4.52065" /score="-6.81136789" /energy="-9.2" /TU="U1313,U1315" /idTUdmin="U1313" /TUdmin="-267" /isTUend="FALSE" /label="downshifts" S_feature 1505410..1505529 /Source="Nicolas_S_feature" /locus_tag="new_1680259_1680378" /HighExp="Cold, Lbstat, H2O2, Glu, Paraq, Mal, G135, GM 90, Oxctl, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S582" promotor_-35 1505501..1505508 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1505522..1505541 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1505531 /Source="Nicolas_upshifts" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1505582..1506739 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2548486, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (beta subunit)" /protein_id="NP_389491.1" /db_xref="EnsemblGenomes-Gn:BSU16090" /db_xref="EnsemblGenomes-Tr:CAB13482" /db_xref="GOA:P80886" /db_xref="InterPro:IPR005809" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013650" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017866" /db_xref="SubtiList:BG12680" /db_xref="UniProtKB/Swiss-Prot:P80886" /translation="MNIHEYQGKEVLRKYGVSVPEGKVAFTAEEAVESAKSLSSSVYV VKAQIHAGGRGKAGGVKIAKSLDEVKAYAEELLGKTLVTHQTGPDGQVIKRLLIEEGC DIKKEYYIGLVLDRATSRIVLMASEEGGTEIEEVAEKTPEKIKKAVIDPAVGLQGYQA REIAFAINIPKELVGKAAKFMLGLYKAFVEKDCSIAEINPLVVTGDGNVMALDAKLNF DSNALYRQKDIMEYRDLDEEDPKEIEASKYDLSYISLDGNIGCMVNGAGLAMSTMDII KHYGGEPANFLDVGGGATAEKVTEAFKIILSDQNVKGIFVNIFGGIMKCDVIAEGVVE ATRQVGLTLPLVVRLEGTNVDLGKKILSESGLNITSAESMADGAQKIVSLV*" /label="sucC CDS" gene 1505582..1506739 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /label="sucC gene" promotor_no_box complement(1505654..1505754) /Source="Nicolas_upshift_promotors" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1505694) /Source="Nicolas_upshifts" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1506768..1507670 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9643546, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (alpha subunit)" /protein_id="NP_389492.1" /db_xref="EnsemblGenomes-Gn:BSU16100" /db_xref="EnsemblGenomes-Tr:CAB13483" /db_xref="GOA:P80865" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR005810" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017440" /db_xref="InterPro:IPR033847" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12681" /db_xref="UniProtKB/Swiss-Prot:P80865" /translation="MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKG GTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPV LDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEA AEWVKANMTKPVVGFIGGKTAPPGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAET PSVMGETLIKVLKEKNLFETCKTH*" /label="sucD CDS" gene 1506768..1507670 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /label="sucD gene" downshifts 1507660 /Source="Nicolas_upshifts" /id="D891" /incds=0 /nref=94 /ntot=208 /MaxReadThrough="5.40077" /MaxDrop="4.8878" /score="9.51199539" /energy="-15" /TU="U1317" /idTUdmin="U1315" /TUdmin=2130 /isTUend="FALSE" /label="downshifts" CDS 1507731..1508624 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA processing Smf single strand binding protein" /protein_id="NP_389493.1" /db_xref="EnsemblGenomes-Gn:BSU16110" /db_xref="EnsemblGenomes-Tr:CAB13484" /db_xref="GOA:P39813" /db_xref="InterPro:IPR003488" /db_xref="SubtiList:BG11006" /db_xref="UniProtKB/Swiss-Prot:P39813" /translation="MDQAAVCLTICRINQLLSPSLLLKWWKADPSMSLTSPVLQTVTR DQIKAAALKNEIEQFYPKLPRVLAAYREQGINTIPISSKQYPFWLKSIYDPPAVLFAK GDMTLLSKGRKIGIVGTRNPTAYGKQVVNHLTKEICRKGWVIVSGLASGIDGMSHAAS IKAKGRTIGVIAGGFQHIYPRENLQLADHMAKHHILLSEHPPETKPQKWHFPMRNRII SGLSEGVIVVQGKEKSGSLITAYQALEQGREVFAVPGSLFDPYAGGPIKLIQQGAKAI WSAEDIFEELPERNVQYTEPF*" /label="dprA CDS" gene 1507731..1508624 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /label="dprA gene" promotor_-35 1508630..1508637 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1508652..1508671 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1508659..1508811 /Source="Nicolas_S_feature" /locus_tag="new_1683508_1683660" /HighExp="dia15, H2O2, G/S, Paraq, Diami, S1, Oxctl, LBGexp, C30, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.111279" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigD, SigA, SigA" /TUlongPSig="1, 1, 1" /label="S583" upshifts 1508659 /Source="Nicolas_upshifts" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1508812..1510887 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /EC_number="5.99.1.2" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9580687, 12682299, 16585761, 23133654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9580687, 12682299, 16585761, 23133654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase I" /protein_id="NP_389494.1" /db_xref="EnsemblGenomes-Gn:BSU16120" /db_xref="EnsemblGenomes-Tr:CAB13485" /db_xref="GOA:P39814" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005733" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013498" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR028612" /db_xref="InterPro:IPR034149" /db_xref="SubtiList:BG11007" /db_xref="UniProtKB/Swiss-Prot:P39814" /translation="MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGV DIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDL NSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKK GLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPL NSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMM IAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPA KKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMS VDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPE QHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQI VLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMK EVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGE GNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVE CDYKEEPQK*" /label="topA CDS" gene 1508812..1510887 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /label="topA gene" downshifts 1510857 /Source="Nicolas_upshifts" /id="D892" /incds=0 /nref=48 /ntot=173 /MaxReadThrough="5.66787" /MaxDrop="4.5486" /score="0.939045188" /energy="-13.2" /TU="U1319" /idTUdmin="U1317" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 1510919..1510924 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1510931 /Source="Nicolas_upshifts" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1510940..1510958 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1510963..1512270 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /EC_number="2.1.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16027442, 21561081, 23095745, 23157377, 27825927, 28745052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16027442, 21561081, 23095745, 23157377, 27825927, 28745052; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA:m(5)U-54 methyltransferase" /protein_id="NP_389495.1" /db_xref="EnsemblGenomes-Gn:BSU16130" /db_xref="EnsemblGenomes-Tr:CAB13486" /db_xref="GOA:P39815" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004417" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11008" /db_xref="UniProtKB/Swiss-Prot:P39815" /translation="MNQQTVNVIGAGLAGSEAAWQLAKRGIQVKLYEMRPVKQTPAHH TDKFAELVCSNSLRSNTLANAVGVLKEEMRALDSAIIAAADECSVPAGGALAVDRHEF AASVTNRVKNHPNVTVINEEVTEIPEGPTIIATGPLTSESLSAQLKELTGEDYLYFYD AAAPIVEKDSLDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFHEALTSAETVPLKEFE KEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEHPVTGKRPYAVVQLRQDDAAGTLYN IVGFQTHLKWGDQKEVLKLIPGLENVEIVRYGVMHRNTFINSPSLLKPTYQFKNRSDL FFAGQMTGVEGYVESAASGLVAGINAAKLVLGEELVIFPQETAIGSMAHYITTTNQKN FQPMNANFGLLKELPVKIKNKKERNEQYANRAIETIQTISKTI*" /label="trmFO CDS" gene 1510963..1512270 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /label="trmFO gene" promotor_-35 1512276..1512280 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1512297..1512316 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1512307 /Source="Nicolas_upshifts" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1512338..1513252 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /function="16.9: Replicate" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11208805, 16553881, 16597952, 21239579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11208805, 16553881, 16597952, 21239579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_389496.1" /db_xref="EnsemblGenomes-Gn:BSU16140" /db_xref="EnsemblGenomes-Tr:CAB13487" /db_xref="GOA:P39776" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011931" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG10965" /db_xref="UniProtKB/Swiss-Prot:P39776" /translation="MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH LPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRG GPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLS STQIYTHVSKEMLRNTYMSHHPRAFKKN*" /label="codV CDS" gene 1512338..1513252 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /label="codV gene" promotor_-35 1512377..1512381 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-35" upshifts 1512394 /Source="Nicolas_upshifts" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="upshifts" promotor_-10 1512397..1512416 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-10" CDS 1513265..1513810 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /EC_number="3.4.25.2" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (N-terminalserine protease)" /protein_id="NP_389497.1" /db_xref="EnsemblGenomes-Gn:BSU16150" /db_xref="EnsemblGenomes-Tr:CAB13488" /db_xref="GOA:P39070" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022281" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:1YYF" /db_xref="PDB:2Z3A" /db_xref="PDB:2Z3B" /db_xref="SubtiList:BG10966" /db_xref="UniProtKB/Swiss-Prot:P39070" /translation="MSSFHATTIFAVQHKGRSAMSGDGQVTFGQAVVMKHTARKVRKL FNGKVLAGFAGSVADAFTLFEKFEAKLEEYNGNLKRAAVELAKEWRSDKVLRKLEAML IVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKKHAGESMSASEIARAA LETAGEICVYTNDQIILEELE*" /label="clpQ CDS" gene 1513265..1513810 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /label="clpQ gene" CDS 1513827..1515230 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (ATPase andchaperone)" /protein_id="NP_389498.1" /db_xref="EnsemblGenomes-Gn:BSU16160" /db_xref="EnsemblGenomes-Tr:CAB13489" /db_xref="GOA:P39778" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004491" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10967" /db_xref="UniProtKB/Swiss-Prot:P39778" /translation="MEKKPLTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDE KLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEATKFTEVGYVGRDVESMV RDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQSGVKNPFEMFFGGSQP NGEDEAESQEEANIEEKRKRMAHQLALGELEDYYVTVEVEEQQPSMFDMLQGSGMEQM GMNMQDALSGLMPKKKKRRKMTVREARKVLTNEEASKLIDMDEVGQEAVQRAEESGII FIDEIDKIAKNGGASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTDHVLFIAAGAF HMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEF SDEAIHKIAEVAYHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVE EKLGTIAKNKDLSQFIL*" /label="clpY CDS" gene 1513827..1515230 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /label="clpY gene" CDS 1515270..1516049 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, GTP and BCAA-dependent" /protein_id="NP_389499.1" /db_xref="EnsemblGenomes-Gn:BSU16170" /db_xref="EnsemblGenomes-Tr:CAB13490" /db_xref="GOA:P39779" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR013198" /db_xref="InterPro:IPR014154" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2B0L" /db_xref="PDB:2B18" /db_xref="PDB:2GX5" /db_xref="PDB:2HGV" /db_xref="PDB:5LNH" /db_xref="PDB:5LOE" /db_xref="PDB:5LOJ" /db_xref="PDB:5LOO" /db_xref="SubtiList:BG10968" /db_xref="UniProtKB/Swiss-Prot:P39779" /translation="MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSR RGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVEN RDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAE EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIV NALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH*" /label="codY CDS" gene 1515270..1516049 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /label="codY gene" downshifts 1516024 /Source="Nicolas_upshifts" /id="D893" /incds=0 /nref=6 /ntot=130 /MaxReadThrough="5.35492" /MaxDrop="5.90286" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1516068 /Source="Nicolas_upshifts" /id="D894" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="4.95658" /MaxDrop="4.85551" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1516169..1516176 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1516189..1516207 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1516200..1516353 /Source="Nicolas_S_feature" /locus_tag="new_1691049_1691202" /HighExp="C30, GM 90, GM 25, Cold, GM 15, GM 10, MG 150, GM-0.2, LBGstat, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 0.994, 0.998" /TUlongSig="SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.999, 1, 1, 1" /label="S584" upshifts 1516200 /Source="Nicolas_upshifts" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1516328..1516335 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1516350..1516369 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1516355 /Source="Nicolas_upshifts" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1516429..1516818 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996, 17850253, 25843804; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389500.1" /db_xref="EnsemblGenomes-Gn:BSU16180" /db_xref="EnsemblGenomes-Tr:CAB13491" /db_xref="GOA:P24500" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006300" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10237" /db_xref="UniProtKB/Swiss-Prot:P24500" /translation="MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSF QNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQ NQINYQALVERMNGKFNSLKTVLTGGK*" /label="flgB CDS" gene 1516429..1516818 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /label="flgB gene" CDS 1516818..1517270 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389501.1" /db_xref="EnsemblGenomes-Gn:BSU16190" /db_xref="EnsemblGenomes-Tr:CAB13492" /db_xref="GOA:P24501" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006299" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10238" /db_xref="UniProtKB/Swiss-Prot:P24501" /translation="MTAFHSLNVSASALTAQRVRMDVVSSNLANMDTTRAKQVNGEWV PYRRKMVSLQSKGESFSSILNSQMSGSGNAGNGVKVSKITEDDSDFNLVYDPTDPDAN AEGYVQKPNVDPLKEMVDLVSSTRSYEANVTAMNATKGMLMKALEIGK*" /label="flgC CDS" gene 1516818..1517270 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /label="flgC gene" SCAR 1517271..1517272 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_004" CDS 1517327..1518091 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-28 factor (sigma-D)" /protein_id="NP_389529.1" /db_xref="EnsemblGenomes-Gn:BSU16470" /db_xref="EnsemblGenomes-Tr:CAB13520" /db_xref="GOA:P10726" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR012845" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10751" /db_xref="UniProtKB/Swiss-Prot:P10726" /translation="MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISV GLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPR TSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEK LHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEEL TLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ*" /label="sigD CDS" gene 1517327..1518091 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /label="sigD gene" promotor_-35 1518101..1518107 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" CDS 1518120..1518623 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15066026, 15175317, 19202088, 21736639, 26244495" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 15175317, 19202088, 21736639, 26244495; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling factor for flagellin transcription and translation" /protein_id="NP_389530.1" /db_xref="EnsemblGenomes-Gn:BSU16480" /db_xref="EnsemblGenomes-Tr:CAB13521" /db_xref="SubtiList:BG10752" /db_xref="UniProtKB/Swiss-Prot:P40405" /translation="MSTLLWLLSFMLHGVLLYAVIILYTRLAAVKETEKQQKQILEET ENTLAAFLLELKEENEKLIENKASSASQSDEESQKSGLQTSETYQERDPVQEAENLPE HIEGLITEVDRREELVNSEVQSFEDQVIELYEQGYSASQIAQKMKSGKTEIELFLKFR SKGVKDS*" /label="swrB CDS" gene 1518120..1518623 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /label="swrB gene" promotor_-10 1518122..1518133 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1518136 /Source="Nicolas_upshifts" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1518619..1518625 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1518640..1518659 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1518642..1518766 /Source="Nicolas_S_feature" /locus_tag="new_1717808_1717932" /HighExp="GM 45, GM 15, H2O2, M9-exp, LBGexp, C30, MG 90, GM-0.1, G135, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S586" upshifts 1518642 /Source="Nicolas_upshifts" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1518767..1519507 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9090122, 10675340, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S2" /protein_id="NP_389531.1" /db_xref="EnsemblGenomes-Gn:BSU16490" /db_xref="EnsemblGenomes-Tr:CAB13522" /db_xref="GOA:P21464" /db_xref="InterPro:IPR001865" /db_xref="InterPro:IPR005706" /db_xref="InterPro:IPR018130" /db_xref="InterPro:IPR023591" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19004" /db_xref="UniProtKB/Swiss-Prot:P21464" /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQ KTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLT NFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDA LFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMA DAILEAKQGEEEAEVAEETAPETETTTA*" /label="rpsB CDS" gene 1518767..1519507 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /label="rpsB gene" downshifts 1519489 /Source="Nicolas_upshifts" /id="D896" /incds=0 /nref=4 /ntot=61 /MaxReadThrough="9.04923" /MaxDrop="4.1312" /score="7.42766835" /energy="-14.3" /TU="U1324,U1328" /idTUdmin="U1323" /TUdmin=869 /isTUend="FALSE" /label="downshifts" S_feature 1519534..1519608 /Source="Nicolas_S_feature" /locus_tag="new_1718700_1718774" /HighExp="LPh, dia0, G150, G180, LBGexp, Lbexp, HPh, Oxctl, dia15, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S587" CDS 1519609..1520490 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6396082, 9244380, 9973356, 27624934; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor Ts" /protein_id="NP_389532.1" /db_xref="EnsemblGenomes-Gn:BSU16500" /db_xref="EnsemblGenomes-Tr:CAB13523" /db_xref="GOA:P80700" /db_xref="InterPro:IPR001816" /db_xref="InterPro:IPR009060" /db_xref="InterPro:IPR014039" /db_xref="InterPro:IPR018101" /db_xref="InterPro:IPR036402" /db_xref="SubtiList:BG19025" /db_xref="UniProtKB/Swiss-Prot:P80700" /translation="MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKG IAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLAN TPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGG RIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGK PENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGI EKRQENFAEEVMNQVKK*" /label="tsf CDS" gene 1519609..1520490 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /label="tsf gene" S_feature 1520491..1520635 /Source="Nicolas_S_feature" /locus_tag="new_1719657_1719801" /HighExp="LBGexp, G150, LBGtran, G135, G180, LPh, Oxctl, dia0, Lbexp, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S588" CDS 1520636..1521358 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /EC_number="2.7.4.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9862121, 12682299, 12869195, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9862121, 12682299, 12869195, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridylate kinase" /protein_id="NP_389533.2" /db_xref="EnsemblGenomes-Gn:BSU16510" /db_xref="EnsemblGenomes-Tr:CAB13524" /db_xref="GOA:O31749" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR011817" /db_xref="InterPro:IPR015963" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12675" /db_xref="UniProtKB/Swiss-Prot:O31749" /translation="MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAEL EVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQ TSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSI MEEGNIKRAVIGESIGTIVRGK*" /label="pyrH CDS" gene 1520636..1521358 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /label="pyrH gene" CDS 1521360..1521917 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9862121, 12480895, 12682299, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome recycling factor" /protein_id="NP_389534.1" /db_xref="EnsemblGenomes-Gn:BSU16520" /db_xref="EnsemblGenomes-Tr:CAB13525" /db_xref="GOA:P81101" /db_xref="InterPro:IPR002661" /db_xref="InterPro:IPR023584" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12587" /db_xref="UniProtKB/Swiss-Prot:P81101" /translation="MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEY YGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAI PALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDV QKLTDEYVSKIDSVTKDKEKEIMEV*" /label="frr CDS" gene 1521360..1521917 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /label="frr gene" downshifts complement(1521864) /Source="Nicolas_upshifts" /id="D897" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="3.38183" /MaxDrop="3.17183" /score="-5.69560888" /energy="-4.8" /TU="NA" /idTUdmin="U1326" /TUdmin="-10739" /isTUend="FALSE" /label="downshifts" promotor_-35 1521906..1521909 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1521924..1521943 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1521942..1522047 /Source="Nicolas_S_feature" /locus_tag="new_1721108_1721213" /HighExp="G180, G135, T3.30H, Oxctl, G150, Cold, Paraq, C30, T3.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S589" upshifts 1521942 /Source="Nicolas_upshifts" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1522048..1522830 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /EC_number="2.5.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15788389, 16014871, 22904278, 23840410, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15788389, 16014871, 22904278, 23840410, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate synthase" /protein_id="NP_389535.1" /db_xref="EnsemblGenomes-Gn:BSU16530" /db_xref="EnsemblGenomes-Tr:CAB13526" /db_xref="GOA:O31751" /db_xref="InterPro:IPR001441" /db_xref="InterPro:IPR018520" /db_xref="InterPro:IPR036424" /db_xref="SubtiList:BG13408" /db_xref="UniProtKB/Swiss-Prot:O31751" /translation="MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGR WAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKL PEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNF MLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI*" /label="uppS CDS" gene 1522048..1522830 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /label="uppS gene" CDS 1522834..1523643 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /EC_number="2.7.7.41" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 175832, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidate cytidylyltransferase (CDP-diglyceride synthase)" /protein_id="NP_389536.1" /db_xref="EnsemblGenomes-Gn:BSU16540" /db_xref="EnsemblGenomes-Tr:CAB13527" /db_xref="GOA:O31752" /db_xref="InterPro:IPR000374" /db_xref="SubtiList:BG12575" /db_xref="UniProtKB/Swiss-Prot:O31752" /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFEL LRMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVK NTFTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGK SLGKRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFG QLGDLVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS*" /label="cdsA" gene 1522834..1523643 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /label="cdsA gene" promotor_-35 1523624..1523631 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1523646..1523665 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1523647 /Source="Nicolas_upshifts" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1523705..1524856 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /EC_number="1.1.1.267" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15567415, 17458547, 21296950, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15567415, 17458547, 21296950, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase" /protein_id="NP_389537.2" /db_xref="EnsemblGenomes-Gn:BSU16550" /db_xref="EnsemblGenomes-Tr:CAB13528" /db_xref="GOA:O31753" /db_xref="InterPro:IPR003821" /db_xref="InterPro:IPR013512" /db_xref="InterPro:IPR013644" /db_xref="InterPro:IPR026877" /db_xref="InterPro:IPR036169" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13409" /db_xref="UniProtKB/Swiss-Prot:O31753" /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVP MIEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGS VGLIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQG EQAKNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGL EVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPD RLPLPDAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAA FLAGKIPFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT*" /label="dxr CDS" gene 1523705..1524856 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /label="dxr gene" CDS 1524863..1526131 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /EC_number="3.4.24.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inner membrane zinc metalloprotease required forthe extracytoplasmic stress response mediated by sigma(W)" /protein_id="NP_389538.1" /db_xref="EnsemblGenomes-Gn:BSU16560" /db_xref="EnsemblGenomes-Tr:CAB13529" /db_xref="GOA:O31754" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR004387" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG13410" /db_xref="UniProtKB/Swiss-Prot:O31754" /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGP KIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQ KEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYN RQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEA GLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDEN KKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGI YDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINRE KEAFVVFIGVAFLMLLMLVVTWNDIQRLFL*" /label="rasP CDS" gene 1524863..1526131 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /label="rasP gene" CDS 1526164..1527858 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /EC_number="6.1.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16864571, 26886480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl-tRNA synthetase" /protein_id="NP_389539.1" /db_xref="EnsemblGenomes-Gn:BSU16570" /db_xref="EnsemblGenomes-Tr:CAB13530" /db_xref="GOA:O31755" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002316" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004500" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR023717" /db_xref="InterPro:IPR033730" /db_xref="InterPro:IPR036621" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12659" /db_xref="UniProtKB/Swiss-Prot:O31755" /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMP LAYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGR EFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDA YSFHASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGE DTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEA CIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVG PVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDP SPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLS AIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDR AERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ*" /label="proS CDS" gene 1526164..1527858 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /label="proS gene" S_feature 1527859..1527966 /Source="Nicolas_S_feature" /locus_tag="new_1727025_1727132" /HighExp="G135, G180, G150, C30, Oxctl, H2O2, Paraq, LPh, LBGexp, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S590" CDS 1527967..1532280 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit)" /protein_id="NP_389540.1" /db_xref="EnsemblGenomes-Gn:BSU16580" /db_xref="EnsemblGenomes-Tr:CAB13531" /db_xref="GOA:P13267" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006308" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR024754" /db_xref="InterPro:IPR028112" /db_xref="InterPro:IPR029460" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG10263" /db_xref="UniProtKB/Swiss-Prot:P13267" /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASK SWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCI EELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPD LQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQ IKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFA REKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKR VELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKM IYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGE IIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNAS FDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHR AIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGL KNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVED IASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYL NDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQ KVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKS IIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPE CQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFS GEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLV QGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLL KLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTL GIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIG CRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKY MFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNS IPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSL F*" /label="polC CDS" gene 1527967..1532280 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /label="polC gene" S_feature 1532281..1532345 /Source="Nicolas_S_feature" /locus_tag="new_1731447_1731511" /HighExp="C30, G180, G135, Oxctl, G150, H2O2, Paraq, Cold, LBGstat, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S591" misc_RNA 1532291..1532508 /gene="surG" /locus_tag="BSU_misc_RNA_71" /product="small RNAs controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surG RNA" gene 1532291..1532508 /gene="surG" /locus_tag="BSU_misc_RNA_71" /label="surG gene" promotor_-35 1532317..1532323 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-35" promotor_-10 1532338..1532349 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-10" S_feature 1532347..1532414 /Source="Nicolas_S_feature" /locus_tag="new_1731513_1731580" /HighExp="S7, S5, S4, S8, S6, S3, G180, C30, T5.0H, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S592" upshifts 1532347 /Source="Nicolas_upshifts" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="upshifts" promotor_-35 1532397..1532403 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-35" S_feature 1532416..1532609 /Source="Nicolas_S_feature" /locus_tag="new_1731582_1731775" /HighExp="LoTm, Cold, HPh, G180, Paraq, Oxctl, T-5.40H, BMM, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S593" upshifts 1532416 /Source="Nicolas_upshifts" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="upshifts" promotor_-10 1532417..1532436 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-10" CDS 1532610..1533080 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15257761, 16014871, 19150615, 20188109, 21529161; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome maturation factor" /protein_id="NP_389541.1" /db_xref="EnsemblGenomes-Gn:BSU16590" /db_xref="EnsemblGenomes-Tr:CAB13532" /db_xref="GOA:P32726" /db_xref="InterPro:IPR003728" /db_xref="InterPro:IPR028989" /db_xref="InterPro:IPR028998" /db_xref="InterPro:IPR035956" /db_xref="InterPro:IPR036847" /db_xref="SubtiList:BG10264" /db_xref="UniProtKB/Swiss-Prot:P32726" /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDS DDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVY IKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF*" /label="rimP CDS" gene 1532610..1533080 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /label="rimP gene" downshifts complement(1532931) /Source="Nicolas_upshifts" /id="D898" /incds=1 /nref=3 /ntot=136 /MaxReadThrough="2.08299" /MaxDrop="3.17419" /score="-8.18111474" /energy="-9.2" /TU="NA" /idTUdmin="U1333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1533115..1534230 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15978071, 16707701, 16946247, 27571753, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15978071, 16707701, 16946247, 27571753, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="transcription translation coupling factor involved in Rho-dependent transcription termination" /protein_id="NP_389542.1" /db_xref="EnsemblGenomes-Gn:BSU16600" /db_xref="EnsemblGenomes-Tr:CAB13533" /db_xref="GOA:P32727" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR010213" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013735" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR025249" /db_xref="InterPro:IPR030842" /db_xref="InterPro:IPR036555" /db_xref="PDB:2MT4" /db_xref="SubtiList:BG10265" /db_xref="UniProtKB/Swiss-Prot:P32727" /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQN VRVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDF GRIAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEAL LPVNEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDG TVELKSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWS SDPVEFVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWK IDIKSETDARELGIYPRELEEDDEPLFTEPETAESDE*" /label="nusA CDS" gene 1533115..1534230 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /label="nusA gene" promotor_no_box complement(1533177..1533277) /Source="Nicolas_upshift_promotors" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1533217) /Source="Nicolas_upshifts" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1534244..1534519 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11679764, 12682299, 26771646, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular ruler co-factor for RNA; new fold" /protein_id="NP_389543.1" /db_xref="EnsemblGenomes-Gn:BSU16610" /db_xref="EnsemblGenomes-Tr:CAB13534" /db_xref="InterPro:IPR007393" /db_xref="InterPro:IPR035931" /db_xref="SubtiList:BG10266" /db_xref="UniProtKB/Swiss-Prot:P32728" /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKN GRGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK*" /label="rulR CDS" gene 1534244..1534519 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /label="rulR gene" CDS 1534521..1534823 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15130481, 15361074, 22355167, 26522935, 26771646" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130481, 15361074, 22355167, 26522935, 26771646; Product type f: factor" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein" /protein_id="NP_389544.1" /db_xref="EnsemblGenomes-Gn:BSU16620" /db_xref="EnsemblGenomes-Tr:CAB13535" /db_xref="GOA:P32729" /db_xref="InterPro:IPR004037" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7Q" /db_xref="SubtiList:BG10267" /db_xref="UniProtKB/Swiss-Prot:P32729" /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDA SSNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD*" /label="rulQ CDS" gene 1534521..1534823 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /label="rulQ gene" CDS 1534843..1536993 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1426242, 9588797, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1426242, 9588797, 12682299, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-2" /protein_id="NP_389545.1" /db_xref="EnsemblGenomes-Gn:BSU16630" /db_xref="EnsemblGenomes-Tr:CAB13536" /db_xref="GOA:P17889" /db_xref="InterPro:IPR000178" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006847" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR015760" /db_xref="InterPro:IPR023115" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036925" /db_xref="SubtiList:BG10268" /db_xref="UniProtKB/Swiss-Prot:P17889" /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIK KLDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKN KKNNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSELI KKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIR PPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGH AAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESAN PDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQ AKGTVIEAELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGP STPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQ IKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASA SNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIG QVEVRQTFKVSKIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKE VSQGYECGITIKKYNDIREGDILEAFVMQEIERT*" /label="infB CDS" gene 1534843..1536993 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /label="infB gene" promotor_-35 1536888..1536894 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1536903 /Source="Nicolas_upshifts" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1536909..1536927 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1536990..1537268 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of conserved protein" /db_xref="EnsemblGenomes-Gn:BSU16640" /db_xref="EnsemblGenomes-Tr:CAB13537" /db_xref="InterPro:IPR007546" /db_xref="InterPro:IPR036746" /db_xref="PSEUDO:CAB13537.1" /db_xref="SubtiList:BG10269" /db_xref="UniProtKB/Swiss-Prot:P32730" /translation="MIGFAECECIIYDAGSLKEKRAVLKRILTRVQNKFNVSISEIGY QDTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF*" /label="ylxP CDS" gene 1536990..1537268 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /pseudo /label="ylxP gene" CDS 1537285..1537638 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12628255, 15185964, 17996707, 21102555, 21529161, 23293003, 23611982, 24671761, 25904134, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="pre-ribosomal (17S) RNA binding factor A" /protein_id="NP_389547.1" /db_xref="EnsemblGenomes-Gn:BSU16650" /db_xref="EnsemblGenomes-Tr:CAB13538" /db_xref="GOA:P32731" /db_xref="InterPro:IPR000238" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020053" /db_xref="InterPro:IPR023799" /db_xref="SubtiList:BG10270" /db_xref="UniProtKB/Swiss-Prot:P32731" /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQ IAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNR IETLIHELHSEKPSE*" /label="rbfA CDS" gene 1537285..1537638 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /label="rbfA gene" downshifts 1537629 /Source="Nicolas_upshifts" /id="D899" /incds=0 /nref=9 /ntot=130 /MaxReadThrough="6.97196" /MaxDrop="5.80207" /score="-3.06560848" /energy="-13.8" /TU="U1331,U1332,U1334" /idTUdmin="U1331" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" CDS 1537720..1538649 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /EC_number="5.4.99.25" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7489483, 15987897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine 55 synthase" /protein_id="NP_389548.1" /db_xref="EnsemblGenomes-Gn:BSU16660" /db_xref="EnsemblGenomes-Tr:CAB13539" /db_xref="GOA:P32732" /db_xref="InterPro:IPR002501" /db_xref="InterPro:IPR014780" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR032819" /db_xref="SubtiList:BG10271" /db_xref="UniProtKB/Swiss-Prot:P32732" /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSG VLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVE KVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHH GETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELE AQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAV FTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ*" /label="truB CDS" gene 1537720..1538649 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /label="truB gene" promotor_-35 1538434..1538441 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1538455..1538474 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1538464 /Source="Nicolas_upshifts" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1538668..1539618 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /EC_number="2.7.1.26" /EC_number="2.7.7.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9473052, 10206712, 12456892, 15668000, 18156273, 21866869" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9473052, 10206712, 12456892, 15668000, 18156273, 21866869; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="bifunctional riboflavin kinase FAD synthase" /protein_id="NP_389549.1" /db_xref="EnsemblGenomes-Gn:BSU16670" /db_xref="EnsemblGenomes-Tr:CAB13540" /db_xref="GOA:P54575" /db_xref="InterPro:IPR002606" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015864" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11495" /db_xref="UniProtKB/Swiss-Prot:P54575" /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQI AEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVF ASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTE QDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNS YIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAI KIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK*" /label="ribC CDS" gene 1538668..1539618 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /label="ribC gene" promotor_-35 1539651..1539657 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1539658..1539774 /Source="Nicolas_S_feature" /locus_tag="new_1738824_1738940" /HighExp="SMM, GM 15, Salt, T-4.40H, GM 45, T-5.40H, GM 60, MG 45, LPhT, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S594" upshifts 1539658 /Source="Nicolas_upshifts" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1539672..1539691 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1539775..1540044 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15627386, 8825778, 20418391, 22720735, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15627386, 8825778, 20418391, 22720735, 23611891; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S15 (BS18)" /protein_id="NP_389550.1" /db_xref="EnsemblGenomes-Gn:BSU16680" /db_xref="EnsemblGenomes-Tr:CAB13541" /db_xref="GOA:P21473" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /db_xref="InterPro:IPR009068" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19010" /db_xref="UniProtKB/Swiss-Prot:P21473" /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLR THKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR*" /label="rpsO CDS" gene 1539775..1540044 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /label="rpsO gene" downshifts 1540027 /Source="Nicolas_upshifts" /id="D900" /incds=0 /nref=30 /ntot=154 /MaxReadThrough="8.65904" /MaxDrop="5.6648" /score="29.9198852" /energy="-10.2" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1331" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" S_feature 1540072..1540157 /Source="Nicolas_S_feature" /locus_tag="new_1739238_1739323" /HighExp="Cold, LoTm, Oxctl, G180, H2O2, G150, dia15, Paraq, LPh, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S595" promotor_-35 1540138..1540141 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1540157..1540176 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1540159 /Source="Nicolas_upshifts" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1540217..1542334 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /EC_number="2.7.7.8" /EC_number="3.1.13.1" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polynucleotide phosphorylase (PNPase)" /protein_id="NP_389551.1" /db_xref="EnsemblGenomes-Gn:BSU16690" /db_xref="EnsemblGenomes-Tr:CAB13542" /db_xref="GOA:P50849" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR012162" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="InterPro:IPR036456" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG11491" /db_xref="UniProtKB/Swiss-Prot:P50849" /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLST ATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPL FADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQ FIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAF QEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNA VVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGL LPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETG PMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLA MMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQM DIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKI RDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQ LYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDK QGRVNLSRKAVLREEKEKEEQQS*" /label="pnpA CDS" gene 1540217..1542334 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /label="pnpA gene" downshifts 1542117 /Source="Nicolas_upshifts" /id="D901" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.05841" /MaxDrop="3.82025" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336,U1337" /idTUdmin="U1337" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 1542318 /Source="Nicolas_upshifts" /id="D902" /incds=0 /nref=192 /ntot=270 /MaxReadThrough="5.61214" /MaxDrop="6.82185" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1337" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature 1542363..1542451 /Source="Nicolas_S_feature" /locus_tag="new_1741529_1741617" /HighExp="G135, G180, G150, H2O2, Oxctl, LBGexp, Paraq, LoTm, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S596" CDS 1542452..1543411 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14679227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar deacetylase" /protein_id="NP_389552.1" /db_xref="EnsemblGenomes-Gn:BSU16700" /db_xref="EnsemblGenomes-Tr:CAB13543" /db_xref="GOA:P50850" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR010916" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014228" /db_xref="SubtiList:BG11492" /db_xref="UniProtKB/Swiss-Prot:P50850" /translation="MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTAS KDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKD LVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKAT FFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTI GVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNG AMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK*" /label="ylxY CDS" gene 1542452..1543411 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /label="ylxY gene" promotor_-10 complement(1542520..1542528) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1542523) /Source="Nicolas_upshifts" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1542542..1542549) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1543015..1543020 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1543036..1543054 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1543041 /Source="Nicolas_upshifts" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1543451..1544680 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10666719, 10974125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666719, 10974125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="specific processing protease" /protein_id="NP_389553.2" /db_xref="EnsemblGenomes-Gn:BSU16710" /db_xref="EnsemblGenomes-Tr:CAB13544" /db_xref="GOA:Q04805" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG10779" /db_xref="UniProtKB/Swiss-Prot:Q04805" /translation="MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGI SHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVL ADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTE ETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEK PEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVRED KGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENS KEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLF TEDYALALISPSGNMPS*" /label="mlpA CDS" gene 1543451..1544680 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /label="mlpA gene" downshifts 1544669 /Source="Nicolas_upshifts" /id="D903" /incds=0 /nref=140 /ntot=219 /MaxReadThrough="1.31218" /MaxDrop="4.84427" /score="15.1952611" /energy="-12.6" /TU="NA" /idTUdmin="U1336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1544709..1544714 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1544724 /Source="Nicolas_upshifts" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1544730..1544748 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1544758..1545015 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /experiment="publication(s) with functional evidences, PMID:23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="PRC barrel protein involved in sporulation" /protein_id="NP_389554.1" /db_xref="EnsemblGenomes-Gn:BSU16720" /db_xref="EnsemblGenomes-Tr:CAB13545" /db_xref="GOA:Q04811" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG10780" /db_xref="UniProtKB/Swiss-Prot:Q04811" /translation="MRLSELSGKEIVDIKRAERLGVLGQTDLEINEQDGQITALLIPT VKWFGLRKQGHDIRVPWHHIQKIGSDMIILDVPEEMPPRQE*" /label="ymxH CDS" gene 1544758..1545015 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /label="ymxH gene" S_feature 1545016..1545070 /Source="Nicolas_S_feature" /locus_tag="new_1744182_1744236" /HighExp="S4, S3, S5, S6, S8, S7, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S597" downshifts 1545043 /Source="Nicolas_upshifts" /id="D904" /incds=0 /nref=41 /ntot=56 /MaxReadThrough="0.534319999999999" /MaxDrop="6.36032" /score="29.434739" /energy="-11.7" /TU="NA" /idTUdmin="U1340" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1545112..1545121 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-35" S_feature 1545131..1545200 /Source="Nicolas_S_feature" /locus_tag="new_1744297_1744366" /HighExp="S6, S8, S7, BT, B36, S5, G/S, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S598" upshifts 1545131 /Source="Nicolas_upshifts" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="upshifts" promotor_-10 1545135..1545154 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-10" CDS 1545201..1546094 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /EC_number="1.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit A" /protein_id="NP_389555.1" /db_xref="EnsemblGenomes-Gn:BSU16730" /db_xref="EnsemblGenomes-Tr:CAB13546" /db_xref="GOA:Q04809" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR014215" /db_xref="InterPro:IPR031629" /db_xref="InterPro:IPR036291" /db_xref="PDB:2RIR" /db_xref="SubtiList:BG10781" /db_xref="UniProtKB/Swiss-Prot:Q04809" /translation="MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTG AVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSG ISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVL GLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICIN TIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTA GQILANVLSKLLAEIQAEEGK*" /label="spoVFA CDS" gene 1545201..1546094 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /label="spoVFA gene" CDS 1546097..1546699 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit B" /protein_id="NP_389556.1" /db_xref="EnsemblGenomes-Gn:BSU16740" /db_xref="EnsemblGenomes-Tr:CAB13547" /db_xref="GOA:Q04810" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG10782" /db_xref="UniProtKB/Swiss-Prot:Q04810" /translation="MSSLKGKRIGFGLTGSHCTYEAVFPQIEELVNEGAEVRPVVTFN VKSTNTRFGEGAEWVKKIEDLTGYEAIDSIVKAEPLGPKLPLDCMVIAPLTGNSMSKL ANAMTDSPVLMAAKATIRNNRPVVLGISTNDALGLNGTNLMRLMSTKNIFFIPFGQDD PFKKPNSMVAKMDLLPQTIEKALMHQQLQPILVENYQGND*" /label="spoVFB CDS" gene 1546097..1546699 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /label="spoVFB gene" misc_feature 1546753..1546772 /Source="Nicolas_upshift_promotors" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1546753..1546824 /Source="Nicolas_S_feature" /locus_tag="new_1745919_1745990" /HighExp="S6, S7, S8, C90, S5, BT, MG 45, MG 5, SMM, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S599" upshifts 1546753 /Source="Nicolas_upshifts" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1546825..1547865 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /EC_number="1.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 12682299, 25355936, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 12682299, 25355936, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="NP_389557.1" /db_xref="EnsemblGenomes-Gn:BSU16750" /db_xref="EnsemblGenomes-Tr:CAB13548" /db_xref="GOA:Q04797" /db_xref="InterPro:IPR000319" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012080" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10783" /db_xref="UniProtKB/Swiss-Prot:Q04797" /translation="MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAG TKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRM DENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVS GAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFE EMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAP GVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSV QIAESLKKLNLV*" /label="asd CDS" gene 1546825..1547865 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /label="asd gene" S_feature 1547866..1547956 /Source="Nicolas_S_feature" /locus_tag="new_1747032_1747122" /HighExp="S7, S6, S8, LBGtran, GM 120, dia15, Heat, LBGstat, GM 90, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S600" CDS 1547957..1549171 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1906928, 8098035" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906928, 8098035; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase I (alpha and beta subunits)" /protein_id="NP_389558.2" /db_xref="EnsemblGenomes-Gn:BSU16760" /db_xref="EnsemblGenomes-Tr:CAB13549" /db_xref="GOA:Q04795" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10784" /db_xref="UniProtKB/Swiss-Prot:Q04795" /translation="MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMG RKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTG AQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDT SAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISP RAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKV PAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPM VTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPA VNALHEVFELSK*" /label="dapG CDS" gene 1547957..1549171 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /label="dapG gene" CDS 1549202..1550074 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /EC_number="4.3.3.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 9298659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 9298659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-tetrahydrodipicolinate synthase" /protein_id="NP_389559.1" /db_xref="EnsemblGenomes-Gn:BSU16770" /db_xref="EnsemblGenomes-Tr:CAB13550" /db_xref="GOA:Q04796" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020624" /db_xref="InterPro:IPR020625" /db_xref="SubtiList:BG10785" /db_xref="UniProtKB/Swiss-Prot:Q04796" /translation="MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAG TTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVM LVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVV AIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQ MIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLT EDERLSLSSTISEL*" /label="dapA CDS" gene 1549202..1550074 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /label="dapA gene" S_feature complement(1549545..1550729) /Source="Nicolas_S_feature" /locus_tag="new_1748711_1749895_c" /HighExp="S8, S6, S4, S5, S7, S3, LoTm, T5.0H, BT, C30" /AntisenseName="dapA" /AntisenseCor="0.13444126275526899" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S601" downshifts 1550081 /Source="Nicolas_upshifts" /id="D905" /incds=0 /nref=17 /ntot=99 /MaxReadThrough="6.0497" /MaxDrop="5.05122" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1341" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1550174..1550177 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1550191 /Source="Nicolas_upshifts" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1550193..1550212 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1550252..1551919 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual activity 5' exo-and endoribonuclease J2" /protein_id="NP_389560.2" /db_xref="EnsemblGenomes-Gn:BSU16780" /db_xref="EnsemblGenomes-Tr:CAB13551" /db_xref="GOA:O31760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13422" /db_xref="UniProtKB/Swiss-Prot:O31760" /translation="MKKKNTENVRIIALGGVGEIGKNLYVIEIDSDIFVVDAGLMHPE NEMLGIDVVIPDISYLIERADRVKAIFLTHGHDENIGGVFYLLNKLSVPVYGTKLTLA LLREKLKQYGHNRKTDLREIHSKSVITFESTKVSFFRTIHSIPDSVGVSFKTSLGSIV CTGDFKFDQTPALNQTCDIGEIAKIGNSGVLALLSDSANAERPGYTPSEAAVSGEISD ALYNSQNRVIIAVFASNINRIQQVIHAAAQNGRKIAVAGKNLQSVLQLARKLGYIEAD DELFISVQDVKKYPKREVAIITAGSQGEPLAALTRMANKAHKQLNIEEGDTVVIASTP IPGQELIYSKTVDLLARAGAQVIFAQKRVHVSGHGSQEELKLMINLLKPKYLIPVNGE YRMQKAHSKIAEETGMKRSDIFLIEKGDVVEFRGQNVKIGDKVPYGNILIDGLGVGDI GNIVLRDRRLLSQDGILIVVITLDKQKKHLVSGPEIITRGFVYVRESEGLIVQATELV RSIVTEATETSNVEWSTLKQAMRDALNQFLYEKTKRKPMIIPIIMEV*" /label="rnjB CDS" gene 1550252..1551919 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /label="rnjB gene" promotor_-10 complement(1550716..1550734) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1550733) /Source="Nicolas_upshifts" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1550750..1550755) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1551907 /Source="Nicolas_upshifts" /id="D906" /incds=0 /nref=227 /ntot=263 /MaxReadThrough="4.0072" /MaxDrop="6.75416" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1551974..1551980 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-35" promotor_-10 1551994..1552005 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-10" upshifts 1551995 /Source="Nicolas_upshifts" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="upshifts" CDS 1552035..1552772 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10455123, 15189290, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455123, 15189290, 23927687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein export-enhancing protease (spore outgrowth)" /protein_id="NP_389561.3" /db_xref="EnsemblGenomes-Gn:BSU16790" /db_xref="EnsemblGenomes-Tr:CAB13552" /db_xref="GOA:Q99171" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11055" /db_xref="UniProtKB/Swiss-Prot:Q99171" /translation="MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIH CLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLA IAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQ TFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDH AGGVGQAINKLNELIDEARKEEGRMIQ*" /label="tepA CDS" gene 1552035..1552772 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /label="tepA gene" CDS 1552769..1552981 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23927687; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of TepA activity (spore outgrowth)" /protein_id="YP_003097729.1" /db_xref="EnsemblGenomes-Gn:BSU16799" /db_xref="EnsemblGenomes-Tr:CAX52620" /db_xref="InterPro:IPR025619" /db_xref="UniProtKB/Swiss-Prot:C0H413" /translation="MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEV IQIMSTNPMHFLHPDISPGQKLKLNV*" /label="tepJ CDS" gene 1552769..1552981 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /label="tepJ gene" misc_feature 1553009..1553028 /Source="Nicolas_upshift_promotors" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1553023 /Source="Nicolas_upshifts" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="upshifts" CDS 1553112..1555475 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11062134, 11778051, 12618465, 16430687, 17139259, 17322320, 18160039, 24297254, 24769697, 26452092; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore DNA directional translocase (motor ATPase)" /protein_id="NP_389562.3" /db_xref="EnsemblGenomes-Gn:BSU16800" /db_xref="EnsemblGenomes-Tr:CAB13553" /db_xref="GOA:P21458" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10763" /db_xref="UniProtKB/Swiss-Prot:P21458" /translation="MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQT FIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQ LFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTG SQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSK KTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIE KRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADK KNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALA LAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISG EAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVY NGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEG AKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVIT GVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLS DDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSML QRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS*" /label="spoIIIE CDS" gene 1553112..1555475 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /label="spoIIIE gene" S_feature 1555476..1555576 /Source="Nicolas_S_feature" /locus_tag="new_1754642_1754742" /HighExp="Cold, C30, G135, Lbstat, BC, G180, G150, S8, LoTm, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.109246" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S602" promotor_-35 1555537..1555544 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1555559..1555578 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1555577 /Source="Nicolas_upshifts" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="upshifts" CDS 1555619..1556344 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family,possibly involved in biofilm formation)" /protein_id="NP_389563.1" /db_xref="EnsemblGenomes-Gn:BSU16810" /db_xref="EnsemblGenomes-Tr:CAB13554" /db_xref="GOA:O31761" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13423" /db_xref="UniProtKB/Swiss-Prot:O31761" /translation="MSTKADNRHLYLKVIERIKEDIKNGIYTEKEKLPSEFELSKKLG VSRATLREALRILEEEHVIIRRHGVGTFVHSKPLFLSGIEQLNSVTKMIEQANMTPGT IFLSSQVLMPSEDDTKRFHLAEGQELFYLERVRTADGQPIVYCIDKIPMNILPNSFSH QQESMFDLLEKNSGSVISYAVTDIEPIGYHDTISPVLECDPETALLLLKQTHYDQHDK PVLYSLNYFRADKFRFHVLRKRF*" /label="ymfC CDS" gene 1555619..1556344 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /label="ymfC gene" downshifts 1556331 /Source="Nicolas_upshifts" /id="D907" /incds=0 /nref=135 /ntot=256 /MaxReadThrough="4.863" /MaxDrop="4.01593" /score="16.3235883" /energy="-7.2" /TU="U1346,U1347" /idTUdmin="U1346" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 1556400..1556406 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1556419 /Source="Nicolas_upshifts" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1556421..1556432 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1556483..1557691 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /function="7: Transport and binding proteins" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18502870, 27375568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18502870, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacillibactin exporter" /protein_id="NP_389564.2" /db_xref="EnsemblGenomes-Gn:BSU16825" /db_xref="EnsemblGenomes-Tr:CAB13555" /db_xref="GOA:O31762" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13424" /db_xref="UniProtKB/Swiss-Prot:O31762" /translation="MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIIT VYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGR VLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWY WFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFI IGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKG RMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESE QCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKK SEEEKNLGTV*" /label="bcbE CDS" gene 1556483..1557691 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /label="bcbE gene" downshifts 1557649 /Source="Nicolas_upshifts" /id="D908" /incds=0 /nref=1 /ntot=32 /MaxReadThrough="1.34389" /MaxDrop="3.00655" /score="5.64651968" /energy="-6.7" /TU="NA" /idTUdmin="U1348" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1557760..1557767 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1557780..1557799 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1557802 /Source="Nicolas_upshifts" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" promotor_-35 1557814..1557817 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1557833..1557845 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1557847 /Source="Nicolas_upshifts" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1557871..1559151 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metalloprotease" /protein_id="NP_389566.2" /db_xref="EnsemblGenomes-Gn:BSU16845" /db_xref="EnsemblGenomes-Tr:CAB13557" /db_xref="GOA:O31764" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG13426" /db_xref="UniProtKB/Swiss-Prot:O31764" /translation="MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTK RALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYL KDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLR LIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQS AIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPA LQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSI IAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDF LANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS*" /label="ymfF CDS" gene 1557871..1559151 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /label="ymfF gene" CDS 1559148..1560434 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative processing protease" /protein_id="NP_389568.2" /db_xref="EnsemblGenomes-Gn:BSU16860" /db_xref="EnsemblGenomes-Tr:CAB13559" /db_xref="GOA:O31766" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG13428" /db_xref="UniProtKB/Swiss-Prot:O31766" /translation="MIKPIEYEQLQETLYHEKMSNGLDVYVLPKKGFNKTYAVFTTKY GSIDNRFVPLGKNEMVHVPDGIAHFLEHKLFEKADGDVFQDFSKQGASANAFTSFTRT AYLFSSTSNVERNLETLIDFVQDPYFTEKTVEKEKGIIGQEINMYDDNPDWRLYFGVI ENMYKEHPVRIDIAGTVESISHITKDLLYECYETFYHPSNMLLFIVGPVDPEAIISQV RENQGKKPYTDQPEIKREEVKEQEAVFRKEKEIKMNVQGPKCLVGLKSKNPFKLGKEL LKHELSMNLLLEALFGKSSAQYESLYEKGYIDETFSFDFTAEYGFGFAAIGGDTPEPD QLAEDISSMLLRAGELITAEKIELARKKKIGTFLKALNSPEYIANQFTRYAFLDMSLF DVVTVLEQITLEDVQNVIQEEIAADRLTVCKVVPKS*" /label="ymfH CDS" gene 1559148..1560434 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /label="ymfH gene" downshifts 1560284 /Source="Nicolas_upshifts" /id="D909" /incds=1 /nref=10 /ntot=159 /MaxReadThrough="5.673" /MaxDrop="3.16735" /score="1.51160893" /energy="-10.4" /TU="U1349,U1350" /idTUdmin="U1350" /TUdmin="-1256" /isTUend="FALSE" /label="downshifts" S_feature 1560435..1560488 /Source="Nicolas_S_feature" /locus_tag="new_1759601_1759654" /HighExp="Etha, dia15, H2O2, G135, G150, G180, Paraq, LBGexp, Oxctl, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.431, 0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S603" CDS 1560489..1561217 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15066026, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 28787546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="EF-P-5 aminopentanone reductase (EF-P repair enzyme), NADPH-dependent" /protein_id="NP_389569.2" /db_xref="EnsemblGenomes-Gn:BSU16870" /db_xref="EnsemblGenomes-Tr:CAB13560" /db_xref="GOA:O31767" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13429" /db_xref="UniProtKB/Swiss-Prot:O31767" /translation="MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELA EKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATV QEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADAT AFLLSEKASYITGQILSVNGGWHC*" /label="efpI CDS" gene 1560489..1561217 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /label="efpI gene" promotor_-35 1561233..1561239 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1561251 /Source="Nicolas_upshifts" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1561253..1561264 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1561264) /Source="Nicolas_upshifts" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1561275..1561289) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1561298..1561302) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1561298..1561555 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389570.1" /db_xref="EnsemblGenomes-Gn:BSU16880" /db_xref="EnsemblGenomes-Tr:CAB13561" /db_xref="InterPro:IPR021637" /db_xref="InterPro:IPR024702" /db_xref="SubtiList:BG13430" /db_xref="UniProtKB/Swiss-Prot:O31768" /translation="MSVLENWDSWKNFLGDRLNYAQDKGMSQDTITDLATEIGSYLAN EVESKNEQEKVLADLWSVASKDEQHAIANMMVKLVENNSTH*" /label="ymfJ CDS" gene 1561298..1561555 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /label="ymfJ gene" downshifts 1561540 /Source="Nicolas_upshifts" /id="D910" /incds=0 /nref=165 /ntot=250 /MaxReadThrough="4.58488" /MaxDrop="7.23574" /score="21.9507801" /energy="-8.7" /TU="U1349,U1351" /idTUdmin="U1350" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1561572) /Source="Nicolas_upshifts" /id="D911" /incds=0 /nref=2 /ntot=15 /MaxReadThrough="3.44398" /MaxDrop="3.96475" /score="-6.33040789" /energy="-7.2" /TU="NA" /idTUdmin="U1344" /TUdmin="-11987" /isTUend="FALSE" /label="downshifts" promotor_-35 1561613..1561616 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1561631..1561650 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1561631 /Source="Nicolas_upshifts" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1561685..1562200 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; N-terminal part of YmfK" /db_xref="SubtiList:BG13431" /translation="MAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSR RGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTF RFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCEQKVAVCVINLA EADDKKPADCR*" /label="ymfKn CDS" gene 1561685..1562200 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /pseudo /label="ymfKn gene" CDS 1562136..1562474 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; C-terminal part of YmfK" /db_xref="SubtiList:BG13432" /translation="RWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERH LQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMF DQSGFSSFDF*" /label="ymfKc CDS" gene 1562136..1562474 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /pseudo /label="ymfKc gene" CDS 1562541..1563407 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 19164570, 22720735, 23879732, 27415800, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 19164570, 22720735, 23879732, 27415800, 27818647; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell shape determination factor" /protein_id="NP_389573.3" /db_xref="EnsemblGenomes-Gn:BSU16910" /db_xref="EnsemblGenomes-Tr:CAB13564" /db_xref="GOA:O31771" /db_xref="InterPro:IPR025194" /db_xref="SubtiList:BG13433" /db_xref="UniProtKB/Swiss-Prot:O31771" /translation="MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEA VGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVI VVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDT KKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDE NSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQT IKIVNKKEEKSS*" /label="rodZ CDS" gene 1562541..1563407 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /label="rodZ gene" promotor_no_box 1562604..1562704 /Source="Nicolas_upshift_promotors" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_no_box" upshifts 1562664 /Source="Nicolas_upshifts" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" downshifts 1563367 /Source="Nicolas_upshifts" /id="D912" /incds=0 /nref=1 /ntot=107 /MaxReadThrough="5.43253" /MaxDrop="2.8328" /score="21.9507801" /energy="-8.7" /TU="U1353,U1354" /idTUdmin="U1351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1563457..1564038 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /EC_number="2.7.8.5" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15743965, 15849754, 16514141, 16850406, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15743965, 15849754, 16514141, 16850406, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="NP_389574.2" /db_xref="EnsemblGenomes-Gn:BSU16920" /db_xref="EnsemblGenomes-Tr:CAB13565" /db_xref="GOA:P46322" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /db_xref="SubtiList:BG11373" /db_xref="UniProtKB/Swiss-Prot:P46322" /translation="MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHL AGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAW MVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN*" /label="pgsA CDS" gene 1563457..1564038 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /label="pgsA gene" CDS 1564056..1565306 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438773, 11703670, 20480359; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence-damage inducible regulator" /protein_id="NP_389575.2" /db_xref="EnsemblGenomes-Gn:BSU16930" /db_xref="EnsemblGenomes-Tr:CAB13566" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008135" /db_xref="InterPro:IPR008136" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036653" /db_xref="SubtiList:BG11374" /db_xref="UniProtKB/Swiss-Prot:P46323" /translation="MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHT AVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQS IEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSEL RPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAA DGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGI TISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSK ECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAG SRTGIRKRGAKYGCHLILKLLEQK*" /label="cinA CDS" gene 1564056..1565306 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /label="cinA gene" S_feature 1565307..1565433 /Source="Nicolas_S_feature" /locus_tag="new_1764473_1764599" /HighExp="LBGstat, LBGtran, G135, Lbstat, G150, C30, LBGexp, dia0, S0, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.016, 0.998" /TUlongSig="SigA" /TUlongPSig="0.987" /label="S604" promotor_-35 1565413..1565420 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1565435..1565454 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1565435 /Source="Nicolas_upshifts" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1565479..1566525 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191; Product type f: factor" /codon_start=1 /transl_table=11 /product="multifunctional SOS repair factor" /protein_id="NP_389576.2" /db_xref="EnsemblGenomes-Gn:BSU16940" /db_xref="EnsemblGenomes-Tr:CAB13567" /db_xref="GOA:P16971" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013765" /db_xref="InterPro:IPR020584" /db_xref="InterPro:IPR020587" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR023400" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10721" /db_xref="UniProtKB/Swiss-Prot:P16971" /translation="MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLA LDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYA QKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDS HVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSS VRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLG TELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQ QQAEETQEELEFEE*" /label="recA CDS" gene 1565479..1566525 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /label="recA gene" downshifts 1566537 /Source="Nicolas_upshifts" /id="D913" /incds=0 /nref=201 /ntot=262 /MaxReadThrough="4.54659" /MaxDrop="9.405" /score="23.91264" /energy="-9.7" /TU="U1355" /idTUdmin="U1353" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 1566582..1566647 /Source="Nicolas_S_feature" /locus_tag="new_1765748_1765813" /HighExp="S7, S5, S8, S4, H2O2, C30, T5.0H, S6, ferm, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="Sig-, SigA, SigA" /TUlongPSig="0.016, 0.998, 0.987" /label="S605" promotor_-35 1566619..1566628 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1566641..1566656 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1566649 /Source="Nicolas_upshifts" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1566693..1567868 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14762009, 15758244, 21856855" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762009, 15758244, 21856855; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding endopeptidase X (lysozyme resistance)" /protein_id="NP_389577.1" /db_xref="EnsemblGenomes-Gn:BSU16950" /db_xref="EnsemblGenomes-Tr:CAB13568" /db_xref="GOA:O31773" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="SubtiList:BG12642" /db_xref="UniProtKB/Swiss-Prot:O31773" /translation="MTSPTRRRTAKRRRRKLNKRGKLLFGLLAVMVCITIWNALHRNS EENEPSQETAAVSNTDQKKEVKKKTAKKSEEQIKTVDRNQKISNYLKEIGFSGTAMIV RNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS TYLPHFPNGQTITLKNLLTHTSGINGHIEGNGAITPDDLIKDIELQGIKRQPGVWDYK DSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYKTYEKEPYPAVGYKMEGSK TVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALIDGKLYSQKSYEKMFTPGSSSTYGMG FYVAPGSYSNHGVMPGFNILNSFSKSGQTIVILFSNIQNNAKLGQVNNKIYQLLNQE* " /label="pbpX CDS" gene 1566693..1567868 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /label="pbpX gene" S_feature 1567869..1567968 /Source="Nicolas_S_feature" /locus_tag="new_1767035_1767134" /HighExp="dia0, LBGexp, Lbexp, Oxctl, Paraq, H2O2, C30, G150, Mt0, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.54369999999999996" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA, Sig-, SigA, SigA" /TUlongPSig="1, 0.016, 0.998, 0.987" /label="S606" promotor_-35 1567942..1567949 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1567963..1567982 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" S_feature 1567970..1568143 /Source="Nicolas_S_feature" /locus_tag="new_1767136_1767309" /HighExp="M9-stat, T3.30H, BC, T2.0H, T3.0H, T-1.40H, T1.30H, T2.30H, T4.0H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S607" upshifts 1567970 /Source="Nicolas_upshifts" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1568144..1569706 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /EC_number="3.1.26.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease Y" /protein_id="NP_389578.1" /db_xref="EnsemblGenomes-Gn:BSU16960" /db_xref="EnsemblGenomes-Tr:CAB13569" /db_xref="GOA:O31774" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR017705" /db_xref="InterPro:IPR022711" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG13420" /db_xref="UniProtKB/Swiss-Prot:O31774" /translation="MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQIL EDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKH EGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIIL ERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPN DEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQD GRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQ NVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATK YKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEE ISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVT VIRETRAVEYAK*" /label="rny CDS" gene 1568144..1569706 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /label="rny gene" downshifts 1569683 /Source="Nicolas_upshifts" /id="D914" /incds=0 /nref=243 /ntot=268 /MaxReadThrough="5.32126" /MaxDrop="5.3789" /score="10.4712371" /energy="-9" /TU="U1357" /idTUdmin="U1357" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" CDS 1569775..1570569 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19376879, 21856853, 24163345, 26904951, 26906740" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19376879, 21856853, 24163345, 26904951, 26906740; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2'3' and 3'5' cyclic nucleotide monophosphates phosphodiesterase involved in biofilm formation" /protein_id="NP_389579.2" /db_xref="EnsemblGenomes-Gn:BSU16970" /db_xref="EnsemblGenomes-Tr:CAB13570" /db_xref="GOA:O31775" /db_xref="InterPro:IPR005235" /db_xref="InterPro:IPR029052" /db_xref="PDB:4B2O" /db_xref="SubtiList:BG13421" /db_xref="UniProtKB/Swiss-Prot:O31775" /translation="MRILFIGDVVGSPGRDMVKEYVPKLKTKYKPHFTIINGENAAHG KGLTEKIYHSLIQSGADAITMGNHTWDKKEIFDFIDDVPNLVRPANFPEGTPGKGITY VKANGKELAVINLQGRTFLPPLDDPFLKADELIAEAAKRTPYIFIDFHAEATSEKLAL GWYTDGRASAVVGTHTHVQTADNRILPKGTAYITDVGMTGPYDGILGMDRETIIKRFK TNLPVRFTVAEGKTTLSGVVIDIDDQTKKAVKIERILINDDHMFFE*" /label="pdeB CDS" gene 1569775..1570569 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /label="pdeB gene" promotor_-35 1570324..1570329 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1570345..1570363 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1570365 /Source="Nicolas_upshifts" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="upshifts" promotor_-35 1570613..1570618 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-35" S_feature 1570629..1570768 /Source="Nicolas_S_feature" /locus_tag="new_1769795_1769934" /HighExp="T5.0H, LoTm, BT, B60, S8, M9-stat, S6, BC, B36, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="0.916, 0.91, 1" /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S608" upshifts 1570629 /Source="Nicolas_upshifts" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="upshifts" promotor_-10 1570634..1570652 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-10" upshifts complement(1570661) /Source="Nicolas_upshifts" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1570672..1570685) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1570694..1570698) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1570705) /Source="Nicolas_upshifts" /id="D915" /incds=0 /nref=5 /ntot=35 /MaxReadThrough="1.51152" /MaxDrop="3.63977" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=10274 /isTUend="FALSE" /label="downshifts" CDS 1570769..1571029 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7559352, 16428420, 18562273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559352, 16428420, 18562273; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for dehydratation of the spore core and assembly of the coat (stage V sporulation)" /protein_id="NP_389580.1" /db_xref="EnsemblGenomes-Gn:BSU16980" /db_xref="EnsemblGenomes-Tr:CAB13571" /db_xref="GOA:P45693" /db_xref="InterPro:IPR007347" /db_xref="SubtiList:BG11245" /db_xref="UniProtKB/Swiss-Prot:P45693" /translation="MEILKVSAKSSPNSVAGALAGVLRERGAAEIQAIGAGALNQAVK AVAIARGFVAPSGVDLICIPAFTDIQIDGEERTAIKLIVEPR*" /label="spoVS CDS" gene 1570769..1571029 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /label="spoVS gene" downshifts 1570981 /Source="Nicolas_upshifts" /id="D916" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="8.31914" /MaxDrop="4.27515" /score="5.18548432" /energy="-12.5" /TU="U1357,U1358,U1359" /idTUdmin="U1357" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts complement(1571013) /Source="Nicolas_upshifts" /id="D917" /incds=0 /nref=3 /ntot=15 /MaxReadThrough="1.16149" /MaxDrop="3.88837" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=9966 /isTUend="FALSE" /label="downshifts" downshifts 1571025 /Source="Nicolas_upshifts" /id="D918" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.08266" /MaxDrop="5.124" /score="5.18548432" /energy="-12.5" /TU="U1358,U1359" /idTUdmin="U1357" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1571070..1571244 /Source="Nicolas_S_feature" /locus_tag="new_1770236_1770410" /HighExp="S6, S8, S7, M9-stat, Lbstat, BT, S5, T1.30H, T2.0H, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.916, 0.91" /TUlongSig="SigA, SigWXY" /TUlongPSig="1, 1" /label="S609" promotor_-35 1571228..1571235 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1571246 /Source="Nicolas_upshifts" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1571250..1571269 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1571295..1572338 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /EC_number="1.1.1.103" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8519804, 16817900, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine 3-dehydrogenase" /protein_id="NP_389581.1" /db_xref="EnsemblGenomes-Gn:BSU16990" /db_xref="EnsemblGenomes-Tr:CAB13572" /db_xref="GOA:O31776" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR004627" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12685" /db_xref="UniProtKB/Swiss-Prot:O31776" /translation="MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICG TDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECV PCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTV SIEKEDPLKIVSALTSGEGADLVCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTI DLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVITHQFPLEEFEKGFEL MRSGQCGKVILIP*" /label="tdh CDS" gene 1571295..1572338 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /label="tdh gene" CDS 1572351..1573529 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /EC_number="2.3.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17146529, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)" /protein_id="NP_389582.1" /db_xref="EnsemblGenomes-Gn:BSU17000" /db_xref="EnsemblGenomes-Tr:CAB13573" /db_xref="GOA:O31777" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR010962" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12610" /db_xref="UniProtKB/Swiss-Prot:O31777" /translation="MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQ LSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEA ALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLE RVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENG RGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAV TAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAK QFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL *" /label="kbl CDS" gene 1572351..1573529 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /label="kbl gene" downshifts 1573511 /Source="Nicolas_upshifts" /id="D919" /incds=0 /nref=3 /ntot=25 /MaxReadThrough="5.75732" /MaxDrop="3.4918" /score="4.73069387" /energy="-12.5" /TU="U1361" /idTUdmin="U1359" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" promotor_-35 1573609..1573612 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1573621 /Source="Nicolas_upshifts" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1573627..1573646 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1573677..1575206 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /EC_number="2.8.4.3" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15175311, 18307109, 20472640, 20584901, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 18307109, 20472640, 20584901, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme for ms(2)i(6)A formation for tRNA modification" /protein_id="NP_389583.1" /db_xref="EnsemblGenomes-Gn:BSU17010" /db_xref="EnsemblGenomes-Tr:CAB13574" /db_xref="GOA:O31778" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006463" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="SubtiList:BG13418" /db_xref="UniProtKB/Swiss-Prot:O31778" /translation="MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGK EAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDD ANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKH PFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIM YGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFED MTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSE VLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEF DSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVL VEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEV K*" /label="miaB CDS" gene 1573677..1575206 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /label="miaB gene" CDS 1575208..1575639 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator for biofilm formation via regulation of RNase Y (RicAFT complex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389584.1" /db_xref="EnsemblGenomes-Gn:BSU17020" /db_xref="EnsemblGenomes-Tr:CAB13575" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR016783" /db_xref="InterPro:IPR023378" /db_xref="PDB:2PIH" /db_xref="SubtiList:BG13417" /db_xref="UniProtKB/Swiss-Prot:O31779" /translation="MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVST IVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLL QLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL*" /label="ricA CDS" gene 1575208..1575639 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /label="ricA gene" downshifts 1575622 /Source="Nicolas_upshifts" /id="D920" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="0.9572" /MaxDrop="7.73043" /score="21.1260722" /energy="-10.3" /TU="NA" /idTUdmin="U1361" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1575770..1575775 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1575791..1575809 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1575799..1575900 /Source="Nicolas_S_feature" /locus_tag="new_1774965_1775066" /HighExp="S3, S5, S8, S4, S6, S7, B36, BT, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S610" upshifts 1575799 /Source="Nicolas_upshifts" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="upshifts" CDS 1575901..1576446 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenic spore protein" /protein_id="NP_389585.1" /db_xref="EnsemblGenomes-Gn:BSU17030" /db_xref="EnsemblGenomes-Tr:CAB13576" /db_xref="GOA:P14016" /db_xref="InterPro:IPR018901" /db_xref="SubtiList:BG10494" /db_xref="UniProtKB/Swiss-Prot:P14016" /translation="MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHK YDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHE VIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWE DELDEELEDINPEFLVGDPEE*" /label="cotE CDS" gene 1575901..1576446 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /label="cotE gene" downshifts 1576440 /Source="Nicolas_upshifts" /id="D921" /incds=0 /nref=64 /ntot=97 /MaxReadThrough="4.37388" /MaxDrop="8.23792" /score="10.7927556" /energy="-12.6" /TU="U1363" /idTUdmin="U1363" /TUdmin="-745" /isTUend="FALSE" /label="downshifts" downshifts complement(1576447) /Source="Nicolas_upshifts" /id="D922" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="4.21458" /MaxDrop="3.44208" /score="12.3953461" /energy="-11.4" /TU="NA" /idTUdmin="U1366" /TUdmin=4532 /isTUend="FALSE" /label="downshifts" promotor_-35 1576504..1576507 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1576522..1576541 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1576526 /Source="Nicolas_upshifts" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="upshifts" CDS 1576579..1579155 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /function="16.5: Explore" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15375129, 16269814, 23998896, 26343983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 16269814, 23998896, 26343983; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA mismatch repair recognition factor" /protein_id="NP_389586.2" /db_xref="EnsemblGenomes-Gn:BSU17040" /db_xref="EnsemblGenomes-Tr:CAB13577" /db_xref="GOA:P49849" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR005748" /db_xref="InterPro:IPR007695" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR007860" /db_xref="InterPro:IPR007861" /db_xref="InterPro:IPR016151" /db_xref="InterPro:IPR017261" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036187" /db_xref="InterPro:IPR036678" /db_xref="SubtiList:BG11403" /db_xref="UniProtKB/Swiss-Prot:P49849" /translation="MAGYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQE LEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYKVAICEQTEDPKAAKGVVKR EVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDV ISEIYSVGAREIVVSGSLDADTVAQLRERCGATISIEDGETDEHVTIIEHLNNEDITK TFLRLYTYLKRTQKRSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKNKKGSLL WLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMVETLMSHFFEREDLRERLKEVYD LERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSL KVGFNKVFGYYIEVTKANLHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNI CELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISENRHYTKPEFSKDEVE VIEGRHPVVEKVMDSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQI GCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDE IGRGTSTYDGMALAQAIIEYVHDHIGAKTLFSTHYHELTVLEDKLPQLKNVHVRAEEY NGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKPEVPVQKP QVKEEPAQLSFFDEAEKPAETPKLSKKEKQVIDAFKSLNILDMTPLEAMNEMYKLQKK LH*" /label="mutS CDS" gene 1576579..1579155 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /label="mutS gene" CDS 1579171..1581054 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15375129, 22843852, 26343983, 26384423, 27369079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 22843852, 26343983, 26384423, 27369079; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA mismatch repair endonuclease" /protein_id="NP_389587.1" /db_xref="EnsemblGenomes-Gn:BSU17050" /db_xref="EnsemblGenomes-Tr:CAB13578" /db_xref="GOA:P49850" /db_xref="InterPro:IPR002099" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR013507" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR014762" /db_xref="InterPro:IPR014790" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020667" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037198" /db_xref="PDB:3GAB" /db_xref="PDB:3KDG" /db_xref="PDB:3KDK" /db_xref="SubtiList:BG11402" /db_xref="UniProtKB/Swiss-Prot:P49850" /translation="MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIE IDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPS IASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAK KMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLP IGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSA QVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPP LQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYI LAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQH KQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREE AAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFK RVM*" /label="mutL CDS" gene 1579171..1581054 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /label="mutL gene" S_feature complement(1580957..1581451) /Source="Nicolas_S_feature" /locus_tag="new_1780123_1780617_c" /HighExp="M9-stat, LBGstat, LPhT, T2.0H, Lbstat, C30, T2.30H, M0t90, T1.30H, HiOs" /AntisenseName="mutL" /AntisenseCor="0.27126904061692803" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S611" downshifts 1580969 /Source="Nicolas_upshifts" /id="D923" /incds=1 /nref=216 /ntot=257 /MaxReadThrough="2.0064" /MaxDrop="5.37369" /score="33.4967163" /energy="-18.6" /TU="NA" /idTUdmin="U1364" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1580979) /Source="Nicolas_upshifts" /id="D924" /incds=1 /nref=3 /ntot=100 /MaxReadThrough="1.93338" /MaxDrop="2.7192" /score="27.1353816" /energy="-13.5" /TU="NA" /idTUdmin="U1366" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1581201..1581208 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1581223..1581242 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1581233..1581366 /Source="Nicolas_S_feature" /locus_tag="new_1780399_1780532" /HighExp="LoTm, T0.30H, T1.30H, M9-stat, T3.0H, BC, T1.0H, B60, B36, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99494800000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S612" upshifts 1581233 /Source="Nicolas_upshifts" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1581238..1581388) /gene="surX" /locus_tag="BSU_misc_RNA_89" /product="small untranslated RNA of unknown function" /note="Evidence 5: Unknown function; PubMedId : 20525796, 23155385" /label="surX RNA" gene complement(1581238..1581388) /gene="surX" /locus_tag="BSU_misc_RNA_89" /label="surX gene" downshifts 1581323 /Source="Nicolas_upshifts" /id="D925" /incds=0 /nref=19 /ntot=136 /MaxReadThrough="3.45962" /MaxDrop="4.12444" /score="29.4045648" /energy="-15.3" /TU="U1365" /idTUdmin="U1364" /TUdmin=354 /isTUend="FALSE" /label="downshifts" CDS complement(1581452..1581907) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="YP_054578.1" /db_xref="EnsemblGenomes-Gn:BSU17060" /db_xref="EnsemblGenomes-Tr:CAE01453" /db_xref="GOA:Q7WY71" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14188" /db_xref="UniProtKB/Swiss-Prot:Q7WY71" /translation="MNQKEQNEHSKDFNLRSKLIGIVSITFIAAIALAVIFGGFFFGM KGLFSILGITYASNQTLALFILACFAVGLIIDPLTKIISIILAKSLSLKKTALFAFIL YFISNLITICFADYFMQSIYIPDVLLVVISAFMAIIELAFDNQPNREAA*" /label="ymzD CDS" gene complement(1581452..1581907) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /label="ymzD gene" S_feature complement(1581908..1581999) /Source="Nicolas_S_feature" /locus_tag="new_1781074_1781165_c" /HighExp="LBGstat, M9-stat, T1.0H, T1.30H, T2.0H, M0t90, MG 150, LPhT, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S613" promotor_-10 complement(1581987..1582006) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1581999) /Source="Nicolas_upshifts" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1582023..1582026) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1582062..1582619) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389588.1" /db_xref="EnsemblGenomes-Gn:BSU17070" /db_xref="EnsemblGenomes-Tr:CAB13579" /db_xref="GOA:O31780" /db_xref="SubtiList:BG13419" /db_xref="UniProtKB/Swiss-Prot:O31780" /translation="MNGIAWMIVFCEIAFWVVIVLGLAVRYVFKRHTLGLLFLALTPV IDLILLAATGVDLYRGASATAAHGIAAVYIGISIAYGKQMIQWADEKFQYYVTKKGTK PLKRFGMDHAKHGAKGWLRHVLAYLIGAGLLAGMIYFINDSSRTEALSGILKLWTVII GIDFLITASYFIWPKKEKASANLRS*" /label="ymcC CDS" gene complement(1582062..1582619) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /label="ymcC gene" SCAR 1582710..1582711 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs08" downshifts complement(1582762) /Source="Nicolas_upshifts" /id="D929" /incds=0 /nref=24 /ntot=184 /MaxReadThrough="3.69744" /MaxDrop="5.18486" /score="-0.71313204" /energy="-20.1" /TU="U1374" /idTUdmin="U1375" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(1582768..1583124) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11544224, 15805528, 20817675" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function involved in ethanol resistance" /protein_id="NP_389606.3" /db_xref="EnsemblGenomes-Gn:BSU17240" /db_xref="EnsemblGenomes-Tr:CAB13608" /db_xref="SubtiList:BG13435" /db_xref="UniProtKB/Swiss-Prot:O31786" /translation="MAHTNTQLSQWLESKVGQTLDIRKGELTHDEEISDLDQIVLHLQ KVAIRSTNHPDDYVAKEELVLEGEGTTFTEDGNVPLPQNAYEIPLLGELHIHQENEGL KVVTDRAVYTIDIQHS*" /label="ymzB CDS" gene complement(1582768..1583124) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /label="ymzB gene" misc_feature complement(1583184..1583197) /Source="Nicolas_upshift_promotors" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1583189) /Source="Nicolas_upshifts" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1583203..1584027) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20817675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389607.2" /db_xref="EnsemblGenomes-Gn:BSU17250" /db_xref="EnsemblGenomes-Tr:CAB13609" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13413" /db_xref="UniProtKB/Swiss-Prot:O31787" /translation="MPYYICNTCGVQHAQTVDPPNSCLICEDERQYIHPDGQTWTTLE DMREKGNLQNILKKEEEHLYSIKTEPEFAIGQTAHLIQHKGFNVLWDCMTYLDQKTID QINELGGIQAIALSHPHYYSTQVEWAEAFQAPIYIHEDDKEWVTRPSNHIHFWSGETL NMKPGLDLYRLGGHFKGGAVLHWSKGNEGKGCLLTGDIITVAADRNWVSFMYSYPNLI PLPASKVEEIAAKVKPLQFNRLYNAFSKVVKENADESVQRSAVRYIKALNSELFHT*" /label="ymaE CDS" gene complement(1583203..1584027) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /label="ymaE gene" promotor_-10 complement(1584049..1584068) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1584065) /Source="Nicolas_upshifts" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1584080..1584086) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1584138..1585466) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10589719, 16267290, 17884659, 28693413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10589719, 16267290, 17884659, 28693413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline serine protease" /protein_id="NP_389608.1" /db_xref="EnsemblGenomes-Gn:BSU17260" /db_xref="EnsemblGenomes-Tr:CAB13610" /db_xref="GOA:O31788" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG12567" /db_xref="UniProtKB/Swiss-Prot:O31788" /translation="MFGYSMVQMVRANAHKLDWPLRETVLQLYKPFKWTPCFLHKFFE TKLQNRKKMSVIIEFEEGCHETGFQMAGEVLQKEKRSKLKSRFNKINCCSAEVTPSAL HSLLSECSNIRKVYLNREVKALLDTATEASHAKEVVRNGQTLTGKGVTVAVVDTGIYP HPDLEGRIIGFADMVNQKTEPYDDNGHGTHCAGDVASSGASSSGQYRGPAPEANLIGV KVLNKQGSGTLADIIEGVEWCIQYNEDNPDEPIDIMSMSLGGDALRYDHEQEDPLVRA VEEAWSAGIVVCVAAGNSGPDSQTIASPGVSEKVITVGALDDNNTASSDDDTVASFSS RGPTVYGKEKPDILAPGVNIISLRSPNSYIDKLQKSSRVGSQYFTMSGTSMATPICAG IAALILQQNPDLTPDEVKELLKNGTDKWKDEDPNIYGAGAVNAENSVPGQ*" /label="aprX CDS" gene complement(1584138..1585466) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /label="aprX gene" downshifts complement(1584145) /Source="Nicolas_upshifts" /id="D930" /incds=0 /nref=13 /ntot=21 /MaxReadThrough="2.43809" /MaxDrop="5.8915" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1376" /TUdmin=8 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1585489..1585508) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1585508) /Source="Nicolas_upshifts" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1585522..1585530) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1585623..1585630 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1585638..1585657) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1585646..1585665 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1585649) /Source="Nicolas_upshifts" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" upshifts 1585652 /Source="Nicolas_upshifts" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1585670..1585677) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1585691..1585768 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of YmzE" /translation="MNFYLHRSLESQMPISIIYEERRND*" /label="ymzEn CDS" gene 1585691..1585768 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /pseudo /label="ymzEn gene" downshifts complement(1585693) /Source="Nicolas_upshifts" /id="D931" /incds=0 /nref=4 /ntot=7 /MaxReadThrough="1.51659" /MaxDrop="5.37668" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1377" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS 1585746..1585922 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of YmzE" /db_xref="PSEUDO:CAX52622.1" /translation="MKKDGTISKRTIIVRQKSKTKIKAFCFSKQQIRTFLLDSILSCD FVRTNKQNLYSAGR*" /label="ymzEc CDS" gene 1585746..1585922 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /pseudo /label="ymzEc gene" downshifts 1585903 /Source="Nicolas_upshifts" /id="D932" /incds=0 /nref=42 /ntot=207 /MaxReadThrough="4.03151" /MaxDrop="6.55778" /score="-0.929304655" /energy="-5.5" /TU="U1378" /idTUdmin="U1378" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature 1585948..1586136 /Source="Nicolas_S_feature" /locus_tag="new_1863194_1863382" /HighExp="H2O2, M40t90, C90, M40t45, C30, S8, HiOs, G135, T-4.40H, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S619" misc_feature 1586131..1586150 /Source="Nicolas_upshift_promotors" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1586138 /Source="Nicolas_upshifts" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1586202..1586909 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /EC_number="3.4.19.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16267290, 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="gamma-polyglutamate hydrolase (phage origin)" /protein_id="NP_389609.1" /db_xref="EnsemblGenomes-Gn:BSU17270" /db_xref="EnsemblGenomes-Tr:CAB13611" /db_xref="GOA:O31789" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13411" /db_xref="UniProtKB/Swiss-Prot:O31789" /translation="MRRFLLNVILVLAIVLFLRYVHYSLEPEPSNQPDTYSNFSSLAE NESPADYDISYNEKKGSKVLIMSPHGGRIEGGVSELVRYFNNEYSTYLFEGLKSHDNQ TLHITSTNFDEPLAKKKIKEHQYVVAFHGYKGENKNTLVGGTDRKRAKMIVRALERRG FSAELASSKSGLAGLNAENINNQGETGLSIQLEISREQREAFFDDFYYKNRKYTKNSE FYAYVSAIKGVLEKEYS*" /label="pghC CDS" gene 1586202..1586909 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /label="pghC gene" promotor_-35 1586920..1586926 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1586940..1586959 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1586944 /Source="Nicolas_upshifts" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1586979..1587431 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290, 22904090, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peroxiredoxin-related protein" /protein_id="NP_389610.1" /db_xref="EnsemblGenomes-Gn:BSU17280" /db_xref="EnsemblGenomes-Tr:CAB13612" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019905" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13412" /db_xref="UniProtKB/Swiss-Prot:O31790" /translation="MADHHFYLKANWPGNRNDVGTIESGNLITSISIPKEMDGPGEGT NPDEMLLGAAATCYIITLAAMMERSGLEKEDLQMESEGIVNVTKGVFTYKKIIHRPSV VLKHDASQDDVALAHKLCKKAESSCMISRAIQGNVELQLEASVKLGGE*" /label="ymaD CDS" gene 1586979..1587431 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /label="ymaD gene" downshifts 1587419 /Source="Nicolas_upshifts" /id="D933" /incds=0 /nref=44 /ntot=182 /MaxReadThrough="1.35366" /MaxDrop="6.07534" /score="17.0193804" /energy="-12.1" /TU="NA" /idTUdmin="U1379" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1587445..1587798) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 15849754, 16750162, 16850406, 18024586, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 15849754, 16750162, 16850406, 18024586, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389611.1" /db_xref="EnsemblGenomes-Gn:BSU17290" /db_xref="EnsemblGenomes-Tr:CAB13613" /db_xref="GOA:P0CW82" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12586" /db_xref="UniProtKB/Swiss-Prot:P0CW82" /translation="MRGLLYLALAIVSEVFGSTMLKLSEGFTQAWPIAGVIVGFLSAF TFLSFSLKTIDLSSAYATWSGVGTALTAIVGFLLFGETISLKGVFGLTLVIAGVVVLN QSKAHAEDKKQTACE*" /label="ebrB CDS" gene complement(1587445..1587798) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /label="ebrB gene" downshifts complement(1587486) /Source="Nicolas_upshifts" /id="D934" /incds=0 /nref=2 /ntot=45 /MaxReadThrough="0.84905" /MaxDrop="2.87924" /score="-2.89884673" /energy="-8.7" /TU="NA" /idTUdmin="U1381" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1587812..1588129) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 11104814, 17516673, 18024586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 11104814, 17516673, 18024586; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389612.1" /db_xref="EnsemblGenomes-Gn:BSU17300" /db_xref="EnsemblGenomes-Tr:CAB13614" /db_xref="GOA:P0CW80" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12585" /db_xref="UniProtKB/Swiss-Prot:P0CW80" /translation="MLIGYIFLTIAICSESIGAAMLKVSDGFKKWKPSALVVIGYSLA FYMLSLTLNHIPLSLSYATWSGAGTVLTTVIGVKWFKEDLNAKGLIGILLLLSGVVLL NWP*" /label="ebrA CDS" gene complement(1587812..1588129) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /label="ebrA gene" promotor_-10 complement(1588173..1588192) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1588181) /Source="Nicolas_upshifts" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1588207..1588214) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1588266..1588541) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19775244, 19933362, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19775244, 19933362, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein; cell wall associated protein" /protein_id="NP_389613.2" /db_xref="EnsemblGenomes-Gn:BSU17310" /db_xref="EnsemblGenomes-Tr:CAB13615" /db_xref="GOA:O31793" /db_xref="SubtiList:BG13415" /db_xref="UniProtKB/Swiss-Prot:O31793" /translation="MNELEHFSPEDTRIFGRPFGFGRPFGFGRPFGFGYGFGRPGFGY GFGRPFGFFGGPFIGGLAGGLIGSALFNPYLYGGYPYYPYAPFPFYY*" /label="ymaG CDS" gene complement(1588266..1588541) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /label="ymaG gene" downshifts complement(1588267) /Source="Nicolas_upshifts" /id="D935" /incds=0 /nref=38 /ntot=44 /MaxReadThrough="0.28059" /MaxDrop="8.33353" /score="12.3408391" /energy="-11.5" /TU="NA" /idTUdmin="U1383" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1588537..1588542 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-35" promotor_-10 1588558..1588576 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-10" promotor_-10 complement(1588568..1588587) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1588578 /Source="Nicolas_upshifts" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="upshifts" upshifts complement(1588581) /Source="Nicolas_upshifts" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1588600..1588609) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1588630..1589043 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24098137, 25915524" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein of unknown function" /protein_id="NP_389614.2" /db_xref="EnsemblGenomes-Gn:BSU17320" /db_xref="EnsemblGenomes-Tr:CAB13616" /db_xref="InterPro:IPR024307" /db_xref="SubtiList:BG13414" /db_xref="UniProtKB/Swiss-Prot:O31794" /translation="MNTLGLYQSDWSKAPPHAHAYHVKTTREQGHYHLIEGFTQPANG SNTDQHTHYYTGITSFENGHFHRYYGISGPAIPLADGTHYHEIEETTYLAYNEPIEIQ YGGVVYDPGDDRRKTHRHTLKGKTREIVGNEPLGW*" /label="ymaF CDS" gene 1588630..1589043 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /label="ymaF gene" upshifts 1589094 /Source="Nicolas_upshifts" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="upshifts" misc_feature 1589100..1589119 /Source="Nicolas_upshift_promotors" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1589143..1590087 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /EC_number="2.5.1.75" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3045085, 11160115, 26735940, 28277934, 28471404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA isopentenylpyrophosphate transferase" /protein_id="NP_389615.2" /db_xref="EnsemblGenomes-Gn:BSU17330" /db_xref="EnsemblGenomes-Tr:CAB13617" /db_xref="GOA:O31795" /db_xref="InterPro:IPR018022" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12617" /db_xref="UniProtKB/Swiss-Prot:O31795" /translation="MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYK GMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVG GTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPN NTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMM QSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQ LTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL*" /label="miaA CDS" gene 1589143..1590087 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /label="miaA gene" promotor_-35 1590067..1590075 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-35" promotor_-10 1590086..1590104 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-10" upshifts 1590088 /Source="Nicolas_upshifts" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="upshifts" CDS 1590127..1590348 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927; Product type f: factor" /codon_start=1 /transl_table=11 /product="Hfq RNA chaperone" /protein_id="NP_389616.1" /db_xref="EnsemblGenomes-Gn:BSU17340" /db_xref="EnsemblGenomes-Tr:CAB13618" /db_xref="GOA:O31796" /db_xref="InterPro:IPR005001" /db_xref="InterPro:IPR010920" /db_xref="PDB:3AHU" /db_xref="PDB:3HSB" /db_xref="SubtiList:BG13416" /db_xref="UniProtKB/Swiss-Prot:O31796" /translation="MKPINIQDQFLNQIRKENTYVTVFLLNGFQLRGQVKGFDNFTVL LESEGKQQLIYKHAISTFAPQKNVQLELE*" /label="hfq CDS" gene 1590127..1590348 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /label="hfq gene" downshifts complement(1590138) /Source="Nicolas_upshifts" /id="D936" /incds=0 /nref=3 /ntot=108 /MaxReadThrough="1.19472" /MaxDrop="3.56162" /score="-5.83707008" /energy="-5.2" /TU="NA" /idTUdmin="U1386" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1590200..1590204) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1590204) /Source="Nicolas_upshifts" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1590219..1590224) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1590348 /Source="Nicolas_upshifts" /id="D937" /incds=0 /nref=26 /ntot=212 /MaxReadThrough="5.10866" /MaxDrop="4.06475" /score="17.2354231" /energy="-17" /TU="U1382,U1385" /idTUdmin="U1384" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1590544..1590816 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389617.1" /db_xref="EnsemblGenomes-Gn:BSU17350" /db_xref="EnsemblGenomes-Tr:CAB13619" /db_xref="InterPro:IPR025448" /db_xref="PDB:3KVP" /db_xref="SubtiList:BG13436" /db_xref="UniProtKB/Swiss-Prot:O31797" /translation="MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYE TPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE*" /label="ymzC CDS" gene 1590544..1590816 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /label="ymzC gene" promotor_-35 1590832..1590839 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1590853..1590872 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1590855 /Source="Nicolas_upshifts" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="upshifts" CDS 1590898..1591128 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389618.1" /db_xref="EnsemblGenomes-Gn:BSU17360" /db_xref="EnsemblGenomes-Tr:CAB13620" /db_xref="SubtiList:BG13434" /db_xref="UniProtKB/Swiss-Prot:O31798" /translation="MKHKVIVNHWEEICEDDSCYEYGTSIIVNGKELIREASIITALK AVLEEIGADVEIEETVESEKCCDSLRKKNLDY*" /label="ymzA CDS" gene 1590898..1591128 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /label="ymzA gene" S_feature 1591129..1591205 /Source="Nicolas_S_feature" /locus_tag="new_1868375_1868451" /HighExp="dia5, dia15, Diami, B60, G150, H2O2, LPhT, G180, G135, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S620" downshifts 1591162 /Source="Nicolas_upshifts" /id="D938" /incds=0 /nref=24 /ntot=61 /MaxReadThrough="7.47169" /MaxDrop="4.19691" /score="8.2587309" /energy="-16.9" /TU="U1385,U1387" /idTUdmin="U1385" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 1591207..1591314 /Source="Nicolas_S_feature" /locus_tag="new_1868453_1868560" /HighExp="G180, G150, G135, H2O2, dia15, Paraq, LBGexp, C30, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S621" promotor_-35 1591287..1591294 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1591308..1591327 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1591316 /Source="Nicolas_upshifts" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="upshifts" CDS 1591371..1591763 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16885274, 21561096, 22443445, 23402532, 26507228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16885274, 21561096, 22443445, 23402532, 26507228; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-factor of ribonucleotide diphosphate reductase" /protein_id="NP_389619.1" /db_xref="EnsemblGenomes-Gn:BSU17370" /db_xref="EnsemblGenomes-Tr:CAB13621" /db_xref="GOA:P50618" /db_xref="InterPro:IPR004465" /db_xref="InterPro:IPR020852" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLJ" /db_xref="SubtiList:BG11426" /db_xref="UniProtKB/Swiss-Prot:P50618" /translation="MVQIIFDSKTGNVQRFVNKTGFQQIRKVDEMDHVDTPFVLVTYT TNFGQVPASTQSFLEKYAHLLLGVAASGNKVWGDNFAKSADTISRQYQVPILHKFELS GTSKDVELFTQEVERVVTKSSAKMDPVK*" /label="nrdI CDS" gene 1591371..1591763 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /label="nrdI gene" CDS 1591723..1593825 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (major subunit)" /protein_id="NP_389620.1" /db_xref="EnsemblGenomes-Gn:BSU17380" /db_xref="EnsemblGenomes-Tr:CAB13622" /db_xref="GOA:P50620" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR008926" /db_xref="InterPro:IPR013346" /db_xref="InterPro:IPR013509" /db_xref="InterPro:IPR013554" /db_xref="InterPro:IPR026459" /db_xref="SubtiList:BG11404" /db_xref="UniProtKB/Swiss-Prot:P50620" /translation="MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQN TVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYN DYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAG RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVEN ATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVK TLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKK EKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVS SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPA VRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAK EKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVA EHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWF FYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTI YYARTKDTGQDSCLSCVV*" /label="nrdE CDS" gene 1591723..1593825 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /label="nrdE gene" CDS 1593843..1594832 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (minor subunit)" /protein_id="NP_389621.1" /db_xref="EnsemblGenomes-Gn:BSU17390" /db_xref="EnsemblGenomes-Tr:CAB13623" /db_xref="GOA:P50621" /db_xref="InterPro:IPR000358" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR026494" /db_xref="InterPro:IPR030475" /db_xref="InterPro:IPR033909" /db_xref="PDB:4DR0" /db_xref="SubtiList:BG11405" /db_xref="UniProtKB/Swiss-Prot:P50621" /translation="MTKIYDAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTW KYLGKNEQDTYMKVLAGLTLLDTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHA KSYSNIFMTLAPTETINEVFEWVKQNKYLQKKAQMIVGLYKAIQKDDEISLFKAMVAS VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVYVGLLAQEIYNKQTE EKKAELREFAIDLLNQLYENELEYTEDLYDQVGLSHDVKKFIRYNANKALMNLGFDPY FEEEDINPIVLNGLNTKTKSHDFFSMKGNGYKKATVEPLKDDDFYFEDEKEQI*" /label="nrdF CDS" gene 1593843..1594832 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /label="nrdF gene" downshifts 1594792 /Source="Nicolas_upshifts" /id="D939" /incds=0 /nref=3 /ntot=106 /MaxReadThrough="6.49299" /MaxDrop="2.8143" /score="-8.26008921" /energy="-10.8" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(1594846..1595505) /Source="Nicolas_S_feature" /locus_tag="new_1872092_1872751_c" /HighExp="BT, B36, C30, Pyr, S8, G135, G/S, Glucon, B60, C90" /AntisenseName="ymaB" /AntisenseCor="-0.136438199650502" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S622" downshifts complement(1594861) /Source="Nicolas_upshifts" /id="D940" /incds=0 /nref=3 /ntot=8 /MaxReadThrough="2.78803" /MaxDrop="4.0424" /score="6.77419677" /energy="-10.8" /TU="NA" /idTUdmin="U1390" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 1594882..1595502 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885274, 21561096; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative cofactor involved in deoxyribonucleotide synthesis" /protein_id="NP_389622.1" /db_xref="EnsemblGenomes-Gn:BSU17400" /db_xref="EnsemblGenomes-Tr:CAB13624" /db_xref="GOA:P50619" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG11427" /db_xref="UniProtKB/Swiss-Prot:P50619" /translation="MGKMDEMILVAPRDDVFKKESLTFQGVYSEDSRVAEIMAQIEAA YREMRRGDAEEDPRFKQPIPYVVIKREDEVFLYERLAGGGESRLHNKLSLGFGGHMNA IEGAASFAEVLKLNTDRELEEELQINEEDKQAIVTLGLINDDENSVGKVHIGILSALQ LKPGAQVEVKEKEQIAGKWMKVSELKQDDIYNRLETWSQFVVDILE*" /label="ymaB CDS" gene 1594882..1595502 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /label="ymaB gene" downshifts 1595483 /Source="Nicolas_upshifts" /id="D941" /incds=0 /nref=130 /ntot=257 /MaxReadThrough="4.3301" /MaxDrop="6.0751" /score="31.3992458" /energy="-16.3" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-35" /isTUend="FALSE" /label="downshifts" promotor_-35 1595518..1595522 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1595540..1595907 /Source="Nicolas_S_feature" /locus_tag="new_1872786_1873153" /HighExp="dia15, G180, H2O2, G135, G150, Diami, Paraq, Oxctl, LBGexp, C30" /AntisenseName="cwlC" /AntisenseCor="-8.9131707018362205E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.231, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S623" upshifts 1595540 /Source="Nicolas_upshifts" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1595544..1595561 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1595550) /Source="Nicolas_upshifts" /id="D942" /incds=0 /nref=1 /ntot=53 /MaxReadThrough="7.25519" /MaxDrop="4.6417" /score="9.14776993" /energy="-8.9" /TU="U1390" /idTUdmin="U1390" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS complement(1595566..1596333) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /EC_number="3.5.1.28" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10515909, 10945275, 10974124, 11375403, 16042392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (sporulation-specific)" /protein_id="NP_389623.2" /db_xref="EnsemblGenomes-Gn:BSU17410" /db_xref="EnsemblGenomes-Tr:CAB13625" /db_xref="GOA:Q06320" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="PDB:1X60" /db_xref="SubtiList:BG10825" /db_xref="UniProtKB/Swiss-Prot:Q06320" /translation="MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYE GVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTT YQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFI QSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLK DGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES*" /label="cwlC CDS" gene complement(1595566..1596333) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /label="cwlC gene" promotor_-10 complement(1596342..1596361) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1596365) /Source="Nicolas_upshifts" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1596374..1596383) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1596487..1596492 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1596508..1596526 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1596508 /Source="Nicolas_upshifts" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1596790..1596795 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-35" promotor_-10 1596812..1596830 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-10" S_feature 1596816..1596956 /Source="Nicolas_S_feature" /locus_tag="new_1874062_1874202" /HighExp="S4, S5, S6, S8, S3, B60, LoTm, S7, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.777" /TUlongSig="NA" /TUlongPSig="NA" /label="S624" upshifts 1596816 /Source="Nicolas_upshifts" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="upshifts" CDS 1596957..1597925 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8464402, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="mother cell sporulation ATPase" /protein_id="NP_389624.2" /db_xref="EnsemblGenomes-Gn:BSU17420" /db_xref="EnsemblGenomes-Tr:CAB13626" /db_xref="GOA:P27643" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR014232" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11039" /db_xref="UniProtKB/Swiss-Prot:P27643" /translation="MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAK HGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPG TGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILF IDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSR FPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGR FVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA*" /label="spoVK CDS" gene 1596957..1597925 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /label="spoVK gene" downshifts 1597894 /Source="Nicolas_upshifts" /id="D943" /incds=0 /nref=5 /ntot=41 /MaxReadThrough="2.7881" /MaxDrop="5.20495" /score="22.9164064" /energy="-15.5" /TU="U1392" /idTUdmin="U1392" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-35 1597989..1597997 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-35" upshifts 1598004 /Source="Nicolas_upshifts" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="upshifts" promotor_-10 1598008..1598027 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-10" CDS 1598058..1599320 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19824612, 26458047, 26733579, 26951678, 27398305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-splitting GTPase (also ATPase, rescuingstalled ribosomes, E-site binding)" /protein_id="NP_389625.2" /db_xref="EnsemblGenomes-Gn:BSU17430" /db_xref="EnsemblGenomes-Tr:CAB13627" /db_xref="GOA:P94478" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016496" /db_xref="InterPro:IPR025121" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030394" /db_xref="InterPro:IPR032305" /db_xref="SubtiList:BG12263" /db_xref="UniProtKB/Swiss-Prot:P94478" /translation="MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKV LTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVK MIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGE TKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFN RLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEE VKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAG RDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFY FNEENEQYDISGYVQEEQSIIGELKKYM*" /label="hflX CDS" gene 1598058..1599320 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /label="hflX gene" CDS 1599338..1600603 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 24610841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_389626.2" /db_xref="EnsemblGenomes-Gn:BSU17440" /db_xref="EnsemblGenomes-Tr:CAB13628" /db_xref="GOA:P94479" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR009651" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12264" /db_xref="UniProtKB/Swiss-Prot:P94479" /translation="MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSY RKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFG VLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVA AAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEEL EPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYS LQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREK MIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYV AYVQGGLTYSHVKNAICSAVDSLMQKQLI*" /label="ynbB CDS" gene 1599338..1600603 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /label="ynbB gene" promotor_-35 1600651..1600658 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1600673..1600692 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1600685 /Source="Nicolas_upshifts" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="upshifts" CDS 1600713..1601120 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (nitrogen metabolism)" /protein_id="NP_389627.1" /db_xref="EnsemblGenomes-Gn:BSU17450" /db_xref="EnsemblGenomes-Tr:CAB13629" /db_xref="GOA:P37582" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4R4E" /db_xref="SubtiList:BG10424" /db_xref="UniProtKB/Swiss-Prot:P37582" /translation="MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEG NRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSD DELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH*" /label="glnR CDS" gene 1600713..1601120 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /label="glnR gene" downshifts complement(1600719) /Source="Nicolas_upshifts" /id="D944" /incds=0 /nref=2 /ntot=82 /MaxReadThrough="1.78139" /MaxDrop="3.45896" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3816 /isTUend="FALSE" /label="downshifts" misc_feature 1601101..1601119 /Source="Nicolas_upshift_promotors" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1601126 /Source="Nicolas_upshifts" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1601179) /Source="Nicolas_upshifts" /id="D945" /incds=0 /nref=1 /ntot=72 /MaxReadThrough="1.70567" /MaxDrop="3.42395" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3356 /isTUend="FALSE" /label="downshifts" CDS 1601179..1602513 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /EC_number="6.3.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine synthetase" /protein_id="NP_389628.1" /db_xref="EnsemblGenomes-Gn:BSU17460" /db_xref="EnsemblGenomes-Tr:CAB13630" /db_xref="GOA:P12425" /db_xref="InterPro:IPR001637" /db_xref="InterPro:IPR004809" /db_xref="InterPro:IPR008146" /db_xref="InterPro:IPR008147" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR027302" /db_xref="InterPro:IPR027303" /db_xref="InterPro:IPR036651" /db_xref="PDB:2FWX" /db_xref="PDB:4LNF" /db_xref="PDB:4LNI" /db_xref="PDB:4LNK" /db_xref="PDB:4LNN" /db_xref="PDB:4LNO" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG10425" /db_xref="UniProtKB/Swiss-Prot:P12425" /translation="MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGK ALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGT PFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLA PTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVV KTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIA GIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEV RSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATL AEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY*" /label="glnA CDS" gene 1601179..1602513 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /label="glnA gene" downshifts 1602490 /Source="Nicolas_upshifts" /id="D946" /incds=0 /nref=266 /ntot=287 /MaxReadThrough="5.53201" /MaxDrop="7.28613" /score="29.7599306" /energy="-16.4" /TU="U1394,U1395" /idTUdmin="U1393" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature 1602535..>1602584 /Source="Nicolas_S_feature" /locus_tag="new_1879781_1880041" /HighExp="Cold, BT, LBGtran, G135, G180, Etha, G150, LBGexp, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S625" SCAR 1602584..1602585 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs04" S_feature <1602585..1603337 /Source="Nicolas_S_feature" /locus_tag="new_1886528_1887351" /HighExp="Lbstat, M0t90, S8, C30, Pyr, Lbtran, M40t90, S1, M/G, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S631" promotor_-10 complement(1602677..1602695) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1602695) /Source="Nicolas_upshifts" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1602711..1602716) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1603338..1604729 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16684115, 16850406, 17183216, 20406496; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+-xyloside symporter" /protein_id="NP_389639.2" /db_xref="EnsemblGenomes-Gn:BSU17570" /db_xref="EnsemblGenomes-Tr:CAB13641" /db_xref="GOA:P94488" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12262" /db_xref="UniProtKB/Swiss-Prot:P94488" /translation="MLSENVKKISMVEKVGYASGDFACNLIYATVSTYLLFFYTDVFG LSAAAAGTMFLVVRIIDALADPFIGTIVDRTNSRFGRFRPYLLFGAFPFVILAILCFT TPDFSDMGKLIYAYITYVGLSLTYTTINVPYGALTSAMTRNNQEVVSITSVRMLFANL GGLVVAFFVPLLAAYLSDTSGNESLGWQLTMGILGMIGGCLLIFCFKSTKERVTLQKS EEKIKFTDIFEQFRVNRPLVVLSIFFIIIFGVNSISNSVGIYYVTYNLEREDLVKWYG LIGSLPALVILPFIPRLHQFLGKKKLLNYALLLNIIGLLALLFVPPSNVYLILVCRLI AAAGSLTAGGYMWALIPETIEYGEYRTGKRMGGLIYAIIGFFFKFGMALGGVVPGLVL DKFGYVANQAQTPAALMGILITTTIIPVFLLVLALIDINFYNLDEKKYKNMVRELENR DKVYLDHIDDFKA*" /label="xynP CDS" gene 1603338..1604729 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /label="xynP gene" CDS 1604760..1606361 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /EC_number="3.2.1.37" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2440680, 6413490, 7816035, 9286998, 9973552, 16684115, 28066362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylan beta-1,4-xylosidase" /protein_id="NP_389640.2" /db_xref="EnsemblGenomes-Gn:BSU17580" /db_xref="EnsemblGenomes-Tr:CAB13642" /db_xref="GOA:P94489" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="PDB:1YIF" /db_xref="SubtiList:BG11987" /db_xref="UniProtKB/Swiss-Prot:P94489" /translation="MKITNPVLKGFNPDPSICRAGEDYYIAVSTFEWFPGVQIHHSKD LVNWHLVAHPLQRVSQLDMKGNPNSGGVWAPCLSYSDGKFWLIYTDVKVVDGAWKDCH NYLVTCETINGDWSEPIKLNSSGFDASLFHDTDGKKYLLNMLWDHRIDRHSFGGIVIQ EYSDKEQKLIGKPKVIFEGTDRKLTEAPHLYHIGNYYYLLTAEGGTRYEHAATIARSA NIEGPYEVHPDNPILTSWHDPGNPLQKCGHASIVQTHTDEWYLAHLTGRPIHPDDDSI FQQRGYCPLGRETAIQKLYWKDEWPYVVGGKEGSLEVDAPSIPETIFEATYPEVDEFE DSTLNINFQTLRIPFTNELGSLTQAPNHLRLFGHESLTSTFTQAFVARRWQSLHFEAE TAVEFYPENFQQAAGLVNYYNTENWTALQVTHDEELGRILELTICDNFSFSQPLNNKI VIPREVKYVYLRVNIEKDKYYYFYSFNKEDWHKIDIALESKKLSDDYIRGGGFFTGAF VGMQCQDTSGNHIPADFRYFRYKEK*" /label="xynB CDS" gene 1604760..1606361 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /label="xynB gene" S_feature complement(1604876..1605181) /Source="Nicolas_S_feature" /locus_tag="new_1888890_1889195_c" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, S4, B36, BC" /AntisenseName="xynB" /AntisenseCor="6.2527836498644102E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S632" promotor_-10 complement(1605176..1605195) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1605181) /Source="Nicolas_upshifts" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1605209..1605217) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1606359 /Source="Nicolas_upshifts" /id="D951" /incds=0 /nref=2 /ntot=53 /MaxReadThrough="1.32947" /MaxDrop="3.8449" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1400" /TUdmin=3190 /isTUend="FALSE" /label="downshifts" CDS complement(1606498..1607652) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1588910, 1719948, 2544559, 7559331; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389641.3" /db_xref="EnsemblGenomes-Gn:BSU17590" /db_xref="EnsemblGenomes-Tr:CAB13643" /db_xref="GOA:P94490" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11986" /db_xref="UniProtKB/Swiss-Prot:P94490" /translation="MDIADQTFVKKVNQKLLLKEILKNSPISRAKLSEMTGLNKSTVS SQVNTLMKESMVFEIGQGQSSGGRRPVMLVFNKKAGYSVGIDVGVDYINGILTDLEGT IVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVF TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIG IGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKEK KLSYQDIINLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMV LNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLDMITM*" /label="xylR CDS" gene complement(1606498..1607652) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /label="xylR gene" downshifts complement(1606501) /Source="Nicolas_upshifts" /id="D952" /incds=0 /nref=9 /ntot=198 /MaxReadThrough="2.56326" /MaxDrop="4.09398" /score="19.297583" /energy="-7.4" /TU="NA" /idTUdmin="U1405" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1607551..1607729) /Source="Nicolas_S_feature" /locus_tag="new_1891565_1891743_c" /HighExp="dia15, Etha, dia5, dia0, Cold, LBGstat, Lbexp, M0t45, Diami, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S633" promotor_-35 1607697..1607703 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1607712..1607731) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1607713..1607729 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1607723 /Source="Nicolas_upshifts" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1607729) /Source="Nicolas_upshifts" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1607746..1607749) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1607756..1607763 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1607778..1607797 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1607789..1607893 /Source="Nicolas_S_feature" /locus_tag="new_1891803_1891907" /HighExp="dia15, dia0, Lbexp, dia5, B60, Sw, G150, LPhT, Mt0, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S634" upshifts 1607790 /Source="Nicolas_upshifts" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="upshifts" CDS 1607894..1609231 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /EC_number="5.3.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7663444, 8132469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7663444, 8132469; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylose isomerase" /protein_id="NP_389642.2" /db_xref="EnsemblGenomes-Gn:BSU17600" /db_xref="EnsemblGenomes-Tr:CAB13644" /db_xref="GOA:P0CI80" /db_xref="InterPro:IPR001998" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR013452" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG10806" /db_xref="UniProtKB/Swiss-Prot:P0CI80" /translation="MAQSHSSSINYFGSANKVVYEGKDSTNPLAFKYYNPQEVIGGKT LKEHLRFSIAYWHTFTADGTDVFGAATMQRPWDHYKGMDLAKMRVEAAFEMFEKLDAP FFAFHDRDIAPEGSTLKETNQNLDMIMGMIKDYMRNSGVKLLWNTANMFTNPRFVHGA ATSCNADVFAYAAAQVKKGLETAKELGAENYVFWGGREGYETLLNTDLKFELDNLARF MHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDTDAATTIAFLKQYGLDNHFKLNLEAN HATLAGHTFEHELRMARVHGLLGSVDANQGHPLLGWDTDEFPTDLYSTTLAMYEILQN GGLGSGGLNFDAKVRRSSFEPDDLIYAHIAGMDAFARGLKVAHKLIEDRVFEDVIQHR YRSFTEGIGLEIIEGRANFHTLEQYALNHKSIKNESGRQEKLKAILNQYILEV*" /label="xylA CDS" gene 1607894..1609231 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /label="xylA gene" S_feature 1609232..1609306 /Source="Nicolas_S_feature" /locus_tag="new_1893246_1893320" /HighExp="dia0, dia15, Sw, Lbexp, dia5, B60, Mt0, M0t45, G150, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S635" downshifts 1609263 /Source="Nicolas_upshifts" /id="D953" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="4.89699" /MaxDrop="3.40404" /score="13.0570501" /energy="-10.2" /TU="U1406" /idTUdmin="U1406" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" CDS 1609382..1610881 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /EC_number="2.7.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1660563, 8866023, 27467131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylulose kinase" /protein_id="NP_389643.1" /db_xref="EnsemblGenomes-Gn:BSU17610" /db_xref="EnsemblGenomes-Tr:CAB13645" /db_xref="GOA:P39211" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006000" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10807" /db_xref="UniProtKB/Swiss-Prot:P39211" /translation="MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSE QNPEDWVQQTIEALAELVSISNVQAKDIDGISYSGQMHGLVLLDQDRQVLRNAILWND TRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKTAVFLLPKDY VRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLL PHVAAKTGLLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDF KGKVHFFNHGKKDSFYTMGVTLAAGYSLDWFKRTFAPNESFEQLLQGVEAIPIGANGL LYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGITFSLHESIELFREAGK SVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEE CAEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN*" /label="xylB CDS" gene 1609382..1610881 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /label="xylB gene" S_feature 1610882..1611197 /Source="Nicolas_S_feature" /locus_tag="new_1894896_1895211" /HighExp="dia0, dia15, Lbexp, dia5, Mt0, M0t45, G150, Etha, Diami, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.51323200000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S636" downshifts 1611155 /Source="Nicolas_upshifts" /id="D954" /incds=0 /nref=60 /ntot=197 /MaxReadThrough="0.61776" /MaxDrop="5.13425" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1611364..1611999) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11584000" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11584000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA nuclease, lipoprotein (phage origin)" /protein_id="NP_389644.1" /db_xref="EnsemblGenomes-Gn:BSU17620" /db_xref="EnsemblGenomes-Tr:CAB13646" /db_xref="GOA:P94492" /db_xref="InterPro:IPR002071" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR035437" /db_xref="SubtiList:BG12265" /db_xref="UniProtKB/Swiss-Prot:P94492" /translation="MKKILISMIAIVLSITLAACGSNHAAKNHSDSNGTEQVSQDTHS NEYNQTEQKAGTPHSKNQKKLVNVTLDRAIDGDTIKVIYNGKKDTVRYLLVDTPETKK PNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLK EGLARVAYVYEPNTKYIDQFRLDEQEAKSDKLSIWSKSGYVTNRGFNGCVK*" /label="yncB CDS" gene complement(1611364..1611999) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /label="yncB gene" promotor_-10 complement(1612036..1612055) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1612045) /Source="Nicolas_upshifts" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1612070..1612077) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1612187..1612194 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1612209..1612228 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1612211..1612409 /Source="Nicolas_S_feature" /locus_tag="new_1896225_1896423" /HighExp="T0.30H, Lbtran, T1.0H, M9-stat, M0t90, T1.30H, M40t90, T2.0H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S637" upshifts 1612211 /Source="Nicolas_upshifts" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="upshifts" CDS 1612410..1613825 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22900538, 23569278; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar transporter" /protein_id="NP_389645.2" /db_xref="EnsemblGenomes-Gn:BSU17630" /db_xref="EnsemblGenomes-Tr:CAB13647" /db_xref="GOA:P94493" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12266" /db_xref="UniProtKB/Swiss-Prot:P94493" /translation="MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQ LDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPN VFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNA ILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIR EDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIM YYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTA LLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSG ISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEE LEEHFRSRHDHNTPEQSVIEV*" /label="yncC CDS" gene 1612410..1613825 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /label="yncC gene" downshifts 1613815 /Source="Nicolas_upshifts" /id="D955" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="0.90595" /MaxDrop="4.35189" /score="15.579587" /energy="-8.6" /TU="NA" /idTUdmin="U1408" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1613918) /Source="Nicolas_upshifts" /id="D956" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="1.08869" /MaxDrop="5.39832" /score="24.3759796" /energy="-9.3" /TU="NA" /idTUdmin="U1409" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1613927..1615111) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /EC_number="5.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10348844, 18399999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10348844, 18399999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine racemase (minor activity)" /protein_id="NP_389646.1" /db_xref="EnsemblGenomes-Gn:BSU17640" /db_xref="EnsemblGenomes-Tr:CAB13648" /db_xref="GOA:P94494" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="PDB:5IRP" /db_xref="SubtiList:BG12267" /db_xref="UniProtKB/Swiss-Prot:P94494" /translation="MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYG HGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNIT LSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKF LRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPE FSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATY IAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGK QGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVL YV*" /label="alrB CDS" gene complement(1613927..1615111) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /label="alrB gene" S_feature complement(1615112..1615191) /Source="Nicolas_S_feature" /locus_tag="new_1899126_1899205_c" /HighExp="S4, S5, S3, S6, S7, B36, BT, S8, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.908" /TUlongSig="NA" /TUlongPSig="NA" /label="S638" promotor_-10 complement(1615184..1615202) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1615195) /Source="Nicolas_upshifts" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1615218..1615223) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1615503..1615510 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1615525..1615544 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1615533 /Source="Nicolas_upshifts" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1615575..1616036 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative prophage protein" /protein_id="NP_389648.2" /db_xref="EnsemblGenomes-Gn:BSU17650" /db_xref="EnsemblGenomes-Tr:CAB13649" /db_xref="InterPro:IPR020216" /db_xref="SubtiList:BG12268" /db_xref="UniProtKB/Swiss-Prot:P94495" /translation="MNRGVSFQIPNEYGNFLWRILQPVEIANYRWQTSGESYFVVEGE LDDEELFHDYEIVEGAVFEQQLKTNQYYTIFVELKAFPYGKMVNQVNTYEEFADSDCE LVLLIADNSYVSIYCKNKNIIEKLYFNALQHDFEDVQFITDENDTRTSLTV*" /label="yncE CDS" gene 1615575..1616036 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /label="yncE gene" CDS 1616066..1616500 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /EC_number="3.6.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11375514, 15939294, 16908222, 17169987, 21358047, 23897460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11375514, 15939294, 16908222, 17169987, 21358047, 23897460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="deoxyuridine 5'-triphosphate pyrophosphatase (phage origin)" /protein_id="NP_389649.1" /db_xref="EnsemblGenomes-Gn:BSU17660" /db_xref="EnsemblGenomes-Tr:CAB13650" /db_xref="GOA:O31801" /db_xref="InterPro:IPR029054" /db_xref="InterPro:IPR033704" /db_xref="InterPro:IPR036157" /db_xref="PDB:2XCD" /db_xref="PDB:2XCE" /db_xref="PDB:4AOO" /db_xref="PDB:4AOZ" /db_xref="PDB:4APZ" /db_xref="PDB:4B0H" /db_xref="SubtiList:BG13437" /db_xref="UniProtKB/Swiss-Prot:O31801" /translation="MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLV PLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDT EIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK*" /label="dutA CDS" gene 1616066..1616500 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /label="dutA gene" S_feature complement(1616249..1616554) /Source="Nicolas_S_feature" /locus_tag="new_1900263_1900568_c" /HighExp="LoTm, S5, T5.0H, S8, T4.0H, S4, S7, T3.30H, Cold, T-4.40H" /AntisenseName="yncF" /AntisenseCor="-0.40042805081531202" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S639" downshifts 1616347 /Source="Nicolas_upshifts" /id="D957" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.18195" /MaxDrop="2.2821" /score="0.171090809" /energy="-9.3" /TU="U1410" /idTUdmin="U1408" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" S_feature 1616501..1617597 /Source="Nicolas_S_feature" /locus_tag="new_1900515_1901611" /HighExp="S8, G150, G180, dia0, G135, UNK1, MG 15, Lbexp, Fru, S7" /AntisenseName="cotU" /AntisenseCor="-0.266961200384908" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S640" S_feature complement(1616556..1616841) /Source="Nicolas_S_feature" /locus_tag="new_1900570_1900855_c" /HighExp="LoTm, dia5, dia15, T3.30H, T3.0H, T-4.40H, T4.0H, T5.0H, T-3.40H, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25207000000000002" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S641" downshifts complement(1616599) /Source="Nicolas_upshifts" /id="D958" /incds=0 /nref=2 /ntot=95 /MaxReadThrough="4.29622" /MaxDrop="2.9464" /score="11.6697365" /energy="-9.7" /TU="U1411" /idTUdmin="U1411" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1616836..1616855) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1616841) /Source="Nicolas_upshifts" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1616867..1616872) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1617103) /Source="Nicolas_upshifts" /id="D959" /incds=0 /nref=17 /ntot=130 /MaxReadThrough="2.07509" /MaxDrop="8.56023" /score="11.6697365" /energy="-9.7" /TU="NA" /idTUdmin="U1412" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1617103..1617363) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12562816, 18065538, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 18065538, 20023017; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389650.1" /db_xref="EnsemblGenomes-Gn:BSU17670" /db_xref="EnsemblGenomes-Tr:CAB13651" /db_xref="GOA:O31802" /db_xref="SubtiList:BG13471" /db_xref="UniProtKB/Swiss-Prot:O31802" /translation="MGYYKKYKEEYYTWKKTYYKKYYDNDKKHYDCDKYYDHDKKHYD YDKKYDDHDKKYYDDHDYHYEKKYYDDDDHYYDFVESYKKHH*" /label="cotU CDS" gene complement(1617103..1617363) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /label="cotU gene" promotor_-10 complement(1617384..1617403) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1617394) /Source="Nicolas_upshifts" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1617416..1617425) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1617598..1617723 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein (putative phage origin)" /db_xref="PSEUDO:CAX52624.1" /translation="MNVMVKIQELYDVIFHTAFEGFRVRHQKQTAKPARNRSYKE*" /label="ynzJ CDS" gene 1617598..1617723 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /pseudo /label="ynzJ gene" S_feature 1617724..1617840 /Source="Nicolas_S_feature" /locus_tag="new_1901738_1901854" /HighExp="G180, G135, G150, dia0, UNK1, S8, Lbexp, C90, MG 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S642" CDS 1617767..1617931 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein from phage origin" /protein_id="YP_009513957.1" /translation="MKLERIYFKESPIAHGQMTIDIEVKYNALNQKKLLEDLMCLDNF QFGIHKHLTI*" /label="conserved hypothetical protein from phage origin CDS" gene 1617767..1617931 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /label="gene" promotor_-35 1617815..1617824 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1617838..1617857 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1617842..1618152 /Source="Nicolas_S_feature" /locus_tag="new_1901856_1902166" /HighExp="S7, S6, S8, S5, BT, G/S, Pyr, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.585202" /TUshortSig="SigK, SigA" /TUshortPSig="0.935, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S643" upshifts 1617842 /Source="Nicolas_upshifts" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1618133..1618140 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1618154..1618173 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1618154 /Source="Nicolas_upshifts" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1618205..1619044 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:416889, 418407, 9648749, 10091656, 10574451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 416889, 418407, 9648749, 10091656, 10574451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase A (phage origin)" /protein_id="NP_389651.1" /db_xref="EnsemblGenomes-Gn:BSU17680" /db_xref="EnsemblGenomes-Tr:CAB13652" /db_xref="GOA:P0CI79" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1B02" /db_xref="PDB:1BKO" /db_xref="PDB:1BKP" /db_xref="PDB:1BSF" /db_xref="PDB:1BSP" /db_xref="SubtiList:BG11190" /db_xref="UniProtKB/Swiss-Prot:P0CI79" /translation="MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVI SKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDG TIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTP CVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNI GDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFE VAV*" /label="thyA CDS" gene 1618205..1619044 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /label="thyA gene" promotor_-10 complement(1618227..1618246) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1618248) /Source="Nicolas_upshifts" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1618261..1618264) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1619004 /Source="Nicolas_upshifts" /id="D960" /incds=0 /nref=6 /ntot=143 /MaxReadThrough="4.34299" /MaxDrop="3.3234" /score="1.39203037" /energy="-7.7" /TU="U1410,U1414" /idTUdmin="U1413" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts complement(1619150) /Source="Nicolas_upshifts" /id="D961" /incds=0 /nref=6 /ntot=150 /MaxReadThrough="3.28185" /MaxDrop="3.73135" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1417" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature complement(1619151..1619457) /Source="Nicolas_S_feature" /locus_tag="new_1903165_1903471_c" /HighExp="LBGstat, Lbstat, LoTm, B60, LPhT, M9-stat, T1.30H, B36, nit, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99924299999999999" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S644" CDS complement(1619167..1619454) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513958.1" /translation="MEHTGHSSFLQLFCLNLTLIRVEIGMKYEKTSLFGMILVIVALL ISIYFMCNTNALIPAGYDLAIHGIVISRTVMIAFTLYLVSKLGYFLLNKKD*" /label="conserved protein of unknown function CDS" gene complement(1619167..1619454) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /label="gene" downshifts complement(1619194) /Source="Nicolas_upshifts" /id="D962" /incds=0 /nref=2 /ntot=85 /MaxReadThrough="3.82042" /MaxDrop="6.47995" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1418" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1619281..1619289 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1619303..1619322 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1619305 /Source="Nicolas_upshifts" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="upshifts" S_feature 1619316..1619476 /Source="Nicolas_S_feature" /locus_tag="new_1903330_1903490" /HighExp="S8, S6, S7, BT, S5, S4, S3, Pyr, G/S, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S645" downshifts 1619448 /Source="Nicolas_upshifts" /id="D963" /incds=0 /nref=13 /ntot=53 /MaxReadThrough="1.26429" /MaxDrop="5.75919" /score="7.35184753" /energy="-11.1" /TU="NA" /idTUdmin="U1416" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1619497..1620219) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_389652.2" /db_xref="EnsemblGenomes-Gn:BSU17690" /db_xref="EnsemblGenomes-Tr:CAB13653" /db_xref="GOA:O31803" /db_xref="InterPro:IPR029143" /db_xref="PDB:4HFS" /db_xref="SubtiList:BG13438" /db_xref="UniProtKB/Swiss-Prot:O31803" /translation="MVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKAASELPNG IGGRVYLNSTGAVFTAKIVLPETVKNNDSVSTPYIYSGFRATSGTEADIGLQYSKQYN VWKPLMKVGSKNEETYIEGKDKFTYNKGFRPGSTVQMTIYKNLSGNTRMTLWGTNNDG YTGRIITEIQGTNIGTISKWKTLATAAVSYESQRDAIKATFSTSFNNITIDNKAVTPV VDTQDFAKVSVAGNNVTISVNK*" /label="yncM CDS" gene complement(1619497..1620219) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /label="yncM gene" downshifts complement(1619502) /Source="Nicolas_upshifts" /id="D964" /incds=0 /nref=31 /ntot=133 /MaxReadThrough="5.62856" /MaxDrop="4.3658" /score="0.425084384" /energy="-11.1" /TU="U1417" /idTUdmin="U1418" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1620244..1620263) /Source="Nicolas_upshift_promotors" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1620252) /Source="Nicolas_upshifts" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1620254..1620378) /Source="Nicolas_S_feature" /locus_tag="new_1904268_1904392_c" /HighExp="H2O2, dia15, S8, G180, G150, Paraq, Oxctl, LBGstat, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S646" CDS complement(1620379..1620735) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function (phage origin)" /protein_id="YP_003097731.1" /db_xref="EnsemblGenomes-Gn:BSU17699" /db_xref="EnsemblGenomes-Tr:CAX52625" /db_xref="GOA:C0H417" /db_xref="InterPro:IPR025621" /db_xref="UniProtKB/Swiss-Prot:C0H417" /translation="MYRNIVFYLILLCLFISVVMKSFEVIRTIANVICFIFVLLYFKD EMKTYSRKALAILSICFLFLVGICAFIILQGQTLMKRHLFFTGLETIAGILLIIVSLS ICTFILRKISNRLKRM*" /label="ynzK CDS" gene complement(1620379..1620735) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /label="ynzK gene" promotor_-10 complement(1620759..1620778) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1620776) /Source="Nicolas_upshifts" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1620794..1620798) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1620975) /Source="Nicolas_upshifts" /id="D965" /incds=0 /nref=58 /ntot=194 /MaxReadThrough="0.902090000000001" /MaxDrop="9.00312" /score="34.0680178" /energy="-10.8" /TU="NA" /idTUdmin="U1419" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1620981..1621181) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389653.2" /db_xref="EnsemblGenomes-Gn:BSU17700" /db_xref="EnsemblGenomes-Tr:CAB13654" /db_xref="GOA:P07790" /db_xref="SubtiList:BG10492" /db_xref="UniProtKB/Swiss-Prot:P07790" /translation="MGYYKKYKEEYYTVKKTYYKKYYEYDKKDYDCDYDKKYDDYDKK YYDHDKKDYDYVVEYKKHKKHY*" /label="cotC CDS" gene complement(1620981..1621181) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /label="cotC gene" downshifts 1621164 /Source="Nicolas_upshifts" /id="D966" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="1.37504" /MaxDrop="5.08099" /score="-4.2739983" /energy="-8" /TU="NA" /idTUdmin="U1416" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1621203..1621222) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1621215) /Source="Nicolas_upshifts" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1621235..1621244) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1621356..1621544) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10974125, 11007775, 26239117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974125, 11007775, 26239117; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_389654.1" /db_xref="EnsemblGenomes-Gn:BSU17710" /db_xref="EnsemblGenomes-Tr:CAB13655" /db_xref="GOA:O31804" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG13464" /db_xref="UniProtKB/Swiss-Prot:O31804" /translation="MELSFTKILVILFVGFLVFGPDKLPALGRAAGKALSEFKQATSG LTQDIRKNDSENKEDKQM*" /label="tatAC CDS" gene complement(1621356..1621544) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /label="tatAC gene" downshifts complement(1621372) /Source="Nicolas_upshifts" /id="D967" /incds=0 /nref=213 /ntot=254 /MaxReadThrough="3.38696" /MaxDrop="6.07983" /score="8.58114058" /energy="-11" /TU="U1420,U1421" /idTUdmin="U1420" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" misc_feature complement(1621513..1621520) /Source="Nicolas_upshift_promotors" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1621526) /Source="Nicolas_upshifts" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1621573..1621592) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1621591) /Source="Nicolas_upshifts" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1621607..1621614) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1621623..1621760 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513959.1" /translation="MNILKPAQRRIHKTAAAEYNVQCHLPKKQEAGWINYVALPEMIQ T*" /label="hypothetical protein CDS" gene 1621623..1621760 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /label="gene" promotor_-35 1621654..1621659 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1621674..1621692 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1621692..1621794 /Source="Nicolas_S_feature" /locus_tag="new_1905706_1905808" /HighExp="S3, S4, LoTm, BT, B36, S5, S7, S6, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.35884500000000003" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S647" upshifts 1621692 /Source="Nicolas_upshifts" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="upshifts" CDS 1621795..1622193 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein of unknown function" /protein_id="NP_389655.1" /db_xref="EnsemblGenomes-Gn:BSU17720" /db_xref="EnsemblGenomes-Tr:CAB13656" /db_xref="SubtiList:BG13439" /db_xref="UniProtKB/Swiss-Prot:O31805" /translation="MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTY TYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGS IGKFVDGSNNKAEFFVTDYSGKSKTVTFYD*" /label="yndA CDS" gene 1621795..1622193 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /label="yndA gene" S_feature 1622194..1622998 /Source="Nicolas_S_feature" /locus_tag="new_1906208_1907012" /HighExp="LoTm, S3, BT, S4, B36, S6, S5, S7, S8, T5.0H" /AntisenseName="yndB" /AntisenseCor="-0.559713635360228" /AntisenseRegPval="-22.9" /CDS_PredictionProba="0.91098199999999996" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S648" CDS complement(1622258..1622692) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /experiment="publication(s) with functional evidences, PMID:20818668, 28160315" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20818668, 28160315; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of stress-related ATPase (flavonoid-sensing)" /protein_id="NP_389656.1" /db_xref="EnsemblGenomes-Gn:BSU17730" /db_xref="EnsemblGenomes-Tr:CAB13657" /db_xref="GOA:O31806" /db_xref="InterPro:IPR013538" /db_xref="InterPro:IPR023393" /db_xref="PDB:2KEW" /db_xref="PDB:2KTE" /db_xref="SubtiList:BG13440" /db_xref="UniProtKB/Swiss-Prot:O31806" /translation="MAQNNENALPDITKSITLEAPIQKVWETVSTSEGIAKWFMPNDF QLKEGQEFHLQSPFGPSPCKVLAVQAPTELSFEWDTEGWVVTFQLEDLGEKTGFTLIH SGWKEPNEVIGKANEKSSVVRGKMDGGWTGIVNERLRKAVEE*" /label="flvS CDS" gene complement(1622258..1622692) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /label="flvS gene" downshifts complement(1622274) /Source="Nicolas_upshifts" /id="D968" /incds=0 /nref=213 /ntot=253 /MaxReadThrough="1.7995" /MaxDrop="6.63594" /score="29.1580701" /energy="-7" /TU="NA" /idTUdmin="U1423" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1622722..1622741) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1622738) /Source="Nicolas_upshifts" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1622755..1622762) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1622999..1623187 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846" /codon_start=1 /transl_table=11 /product="conserved protein involved in spore germination" /protein_id="NP_389657.2" /db_xref="EnsemblGenomes-Gn:BSU17740" /db_xref="EnsemblGenomes-Tr:CAB13658" /db_xref="SubtiList:BG13465" /db_xref="UniProtKB/Swiss-Prot:O31807" /translation="MLGKIKAAIDNSPGKPARILVSEKAFQQLEEEMRFVYVSKPKTI MGIPVEVSDQAESFKLEF*" /label="ynzB CDS" gene 1622999..1623187 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /label="ynzB gene" S_feature 1623188..1623273 /Source="Nicolas_S_feature" /locus_tag="new_1907202_1907287" /HighExp="LoTm, BT, S4, S6, S3, S8, S7, B36, S5, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S649" downshifts 1623232 /Source="Nicolas_upshifts" /id="D969" /incds=0 /nref=7 /ntot=89 /MaxReadThrough="2.20002" /MaxDrop="4.21414" /score="19.5879917" /energy="-11.9" /TU="NA" /idTUdmin="U1422" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1623302..1623308 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1623320..1623479 /Source="Nicolas_S_feature" /locus_tag="new_1907334_1907493" /HighExp="S8, S4, S6, S7, S5, S3, BT, ferm, LoTm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.95681300000000002" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S650" upshifts 1623320 /Source="Nicolas_upshifts" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1623322..1623333 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1623480..1625042 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10762253, 27208128; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_389658.1" /db_xref="EnsemblGenomes-Gn:BSU17750" /db_xref="EnsemblGenomes-Tr:CAB13659" /db_xref="GOA:O31808" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG13441" /db_xref="UniProtKB/Swiss-Prot:O31808" /translation="MMRWRNNQYKTQKQHKSDYSTAEKQDQDVLTGNIGYDLEHVKRK IGHNGDVHFRELEITQLHVKAALIFVEGLSDQDLINKGLSVLVMNQPNQVSDEISQSG KGILTSKQIKNQIVSIGDVIDSEKISDIVLNVFMGSTALLIDGIPQAFLLGTVKKQNR SIEEPLSEALVRGPRTGFTEELSTNTALLRQQGKNDQLTLQRFEVGTRLKKDLIIAYM NDIADPKVVEEVRKRVRGIEIDHLPESGYVEQLIEDNYLSPFPQVQSTERPDRVISGL MEGRVAILLDGTPFALIVPVTFSMMLQSPEDYYERWFPSSLIRLLRFIAAMITLFAPA LYISFISFHPGLIPTKLAISISGTRQGVPFPSLIEALFMEVAIEILREAGLRLPKPIG PAIGIVGGLIIGEAAVQAGIVSPIMVIVVALTAISSFAIPHYSTGIALRMLRFGAMFC AAVFGLFGVIMYYLLLSSHVVKLKSFGVPYASPAVPYHLKDWKDFVIRMPLLVMKRRP KMMNTDNTKRVK*" /label="yndD CDS" gene 1623480..1625042 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /label="yndD gene" promotor_-10 complement(1623783..1623802) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1623792) /Source="Nicolas_upshifts" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1623817..1623824) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1625072..1626163 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane protein" /protein_id="NP_389659.1" /db_xref="EnsemblGenomes-Gn:BSU17760" /db_xref="EnsemblGenomes-Tr:CAB13660" /db_xref="GOA:O31809" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG13442" /db_xref="UniProtKB/Swiss-Prot:O31809" /translation="MFSPTSKITTAQATIIIINYMLAAGVLTLPRTVTEQTQSPDGWI SVLLGGVLAVIAGMIIAKLSQQYPKETFYEYSRHIVGKWLGHLISIVFITYFLALGAF EVRVMSEIVDFFLLEGTPSWAIIMTVLWIGLYSITQGLDPIARLFEMIFPITVIIFLT IALMSLGIFEINNLRPVLGDGIMPVLRGVKTTNLSFTCSEIMFILVAFMKKPKNAVKA VVIGTGVVTSFYMITMIMVIGALSVEGVVTRTWPGLDLMRSFEIPGLIFERFESFLLV IWIMQLFATFIITFYAASLGVSQVFKKKPLSCMFGLLPVIYILSCMPKNENDVFILGD TVSHIALYIFGALPILLLVISKWRKRGEK*" /label="yndE CDS" gene 1625072..1626163 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /label="yndE gene" CDS 1626153..1627367 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 27208128; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative spore germination lipoprotein" /protein_id="NP_389660.1" /db_xref="EnsemblGenomes-Gn:BSU17770" /db_xref="EnsemblGenomes-Tr:CAB13661" /db_xref="GOA:O31810" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG13443" /db_xref="UniProtKB/Swiss-Prot:O31810" /translation="MKSKLKRQLPAMVIVCLLMICVTGCWSSREIEDLGLTFAIAIDK GKETNTEKELKEEGGSYPKKDNITLTYQFVNEKAAGAGTSGGGGSGQGAQKAYINISE TGDSLQQIGSEVALRRDREVFSPHLKVVVMSEDVLHTFPIDEMLDQFFRDNEIRLSCL VLSAKGEARDALQLKENGEIPAFRLIGLGENEHKVSRILPPMTLAKLIGKLHSGSSFL LQNVVAANGAVKYSGAAVINGKSKKMIGTLNEYETEGITWIRGEGKGGVVKSHDKKSQ QTLAYDINKIKSRIQPIVKGKDISFHVDIESEGDLVENWNTKEALDTQFIDRLETTIE NEVKKIVGQVLKKIQHDYKADVAGFDESFRLTYPHLWKRVKNNWDDTFSKADITYSVN VTITHFGTVKTQ*" /label="yndF CDS" gene 1626153..1627367 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /label="yndF gene" promotor_-35 1627445..1627452 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1627467..1627486 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1627478 /Source="Nicolas_upshifts" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="upshifts" CDS 1627514..1628320 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11737947, 22333191, 27435445" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389661.1" /db_xref="EnsemblGenomes-Gn:BSU17780" /db_xref="EnsemblGenomes-Tr:CAB13662" /db_xref="GOA:O31811" /db_xref="SubtiList:BG13444" /db_xref="UniProtKB/Swiss-Prot:O31811" /translation="MRQKPIYVEIEMKSDLDTLWEYTQNPSLHKEWDLRFSNITYLNS QPCEKQKFLYETRVGFGLKVSGTGETVGVFNKCSSERSSSLAFGSDHPLSLIRHGSGY WKYIQRENGKMTFLTQYQYKTAYGLLGRWIDRLLFRPLLGWATAWSFDALRLWVEQNK HPKRFIRSAIIYVFMCLFFSLFWFYQGFAGVKTSILTGTAEIGLAILWLLPLKRKWII HGVQACIFAGFACLGSEIFMWVLLSVFSAASGALSLQLPSARRTKRKRKK*" /label="yndG CDS" gene 1627514..1628320 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /label="yndG gene" S_feature complement(1628128..1629226) /Source="Nicolas_S_feature" /locus_tag="new_1912142_1913240_c" /HighExp="S8, S6, S7, S5, T0.30H, T2.0H, GM 150, BT, T1.30H, T-4.40H" /AntisenseName="yndH" /AntisenseCor="-0.58089150558713998" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S651" CDS 1628325..1628942 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389662.1" /db_xref="EnsemblGenomes-Gn:BSU17790" /db_xref="EnsemblGenomes-Tr:CAB13663" /db_xref="InterPro:IPR025311" /db_xref="SubtiList:BG13445" /db_xref="UniProtKB/Swiss-Prot:O31812" /translation="MSSIYEKSIINYHLLHPKLQKRYQLDGSHTFSGTGTMSEISGGS FLVRMLLKLGVFFRCFFSERGKDIPFTIQNRTCLLKSQHTGIEWNRTFFFKGKKRFFD ALMIYDEKENRILDFFGKPHLLLSVLTFEASLDGSLTITSGKQWLLICGKRIPLPKWL TGTSEVCETFDEKKNCFTIEVHVQNTILGTLFFYKGTFQEEERES*" /label="yndH CDS" gene 1628325..1628942 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /label="yndH gene" CDS 1628939..1630579 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618455, 15849754, 16850406, 28615734; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389663.1" /db_xref="EnsemblGenomes-Gn:BSU17800" /db_xref="EnsemblGenomes-Tr:CAB13664" /db_xref="GOA:O31813" /db_xref="InterPro:IPR025450" /db_xref="SubtiList:BG13446" /db_xref="UniProtKB/Swiss-Prot:O31813" /translation="MKRNGIVSALCFIGFLAAEAPDISVAEALVLLSILFFVPGIFPF VFRQSPVRAAQFMENGLIQCYPVAAFFAVLALVTEVGGFALIWWMYTVFNALYAILRL WETKIHRIEETSVLFGLIYLAGGGFWFFAYAAHLQIMQFGPLIILLTAVHFHYSAFLI PIFNGLLGRTIRKHRMLYSWITWVILLSPLLIALGITYSKTLDVIAVSIYMAAIYLHA FLVFTAAFRTKTGTFLIRLSSAVLMITIAFSMIYSFGVFRQEVTLTINQMIWIHGFVN AFGVILPALIGWRIEDAKPFDADSVKTFSRIYGKRKIGEEFLANIQAENNARYSGLVD DMGSLRSKDFSPEKLAPLILSFYEQTIEYNIKAKVTWSTWFRPLAIIYEWFSRRIGQI HLSTNPDWYRMYSKIKGVHSKKDGRERVRAWIRTNEKNETIFTALYSVYRSNGEGYMN ISLPLPFSSMTGILKPYHHQEKLVLTSRRRKSRAGDEGIYLQTRAGTCPLPLSETFLI EAVHDNKLTAVHHMWLFGIKFLTVHYSITHINQPIERT*" /label="yndJ CDS" gene 1628939..1630579 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /label="yndJ gene" promotor_-10 complement(1629213..1629232) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1629226) /Source="Nicolas_upshifts" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1629246..1629254) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1630219..1630985) /Source="Nicolas_S_feature" /locus_tag="new_1914233_1914999_c" /HighExp="T2.0H, T1.30H, T2.30H, GM 150, T3.30H, T1.0H, C30, T3.0H, T4.0H, T0.30H" /AntisenseName="yndK" /AntisenseCor="-0.33555507319526101" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S652" CDS 1630616..1630981 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage/plasmid replication protein" /protein_id="NP_389664.1" /db_xref="EnsemblGenomes-Gn:BSU17810" /db_xref="EnsemblGenomes-Tr:CAB13665" /db_xref="GOA:O31814" /db_xref="SubtiList:BG13447" /db_xref="UniProtKB/Swiss-Prot:O31814" /translation="MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVD QLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRK IEKNIMKLNQAKKRRMKRK*" /label="yndK CDS" gene 1630616..1630981 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /label="yndK gene" downshifts 1630958 /Source="Nicolas_upshifts" /id="D970" /incds=0 /nref=166 /ntot=243 /MaxReadThrough="2.62352" /MaxDrop="5.68917" /score="15.340233" /energy="-10.4" /TU="NA" /idTUdmin="U1426" /TUdmin=2226 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1630978..1631258) /gene="surA" /locus_tag="BSU_misc_RNA_72" /product="small untranslated RNA controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surA RNA" gene complement(1630978..1631258) /gene="surA" /locus_tag="BSU_misc_RNA_72" /label="surA gene" S_feature complement(1630987..1631118) /Source="Nicolas_S_feature" /locus_tag="new_1915001_1915132_c" /HighExp="B60, T2.0H, T1.30H, T1.0H, T2.30H, M9-stat, LoTm, S5, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.443, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S653" downshifts complement(1631030) /Source="Nicolas_upshifts" /id="D971" /incds=0 /nref=21 /ntot=129 /MaxReadThrough="4.91485" /MaxDrop="4.94426" /score="14.7738511" /energy="-10.4" /TU="U1429,U1431" /idTUdmin="U1429" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1631078..1631087 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1631100..1631109) /Source="Nicolas_upshift_promotors" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1631101..1631120 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1631106 /Source="Nicolas_upshifts" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" S_feature 1631108..1631206 /Source="Nicolas_S_feature" /locus_tag="new_1915122_1915220" /HighExp="S8, S6, S7, BT, S5, G/S, B36, C30, Pyr, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52117199999999997" /TUshortSig="SigK" /TUshortPSig="0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S654" upshifts complement(1631118) /Source="Nicolas_upshifts" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1631120..1631250) /Source="Nicolas_S_feature" /locus_tag="new_1915134_1915264_c" /HighExp="T2.0H, T1.30H, M9-stat, T2.30H, T1.0H, B60, LoTm, T4.0H, T3.30H, T0.30H" /AntisenseName="yndL" /AntisenseCor="0.22331158442510801" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S655" CDS 1631207..1631965 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /EC_number="3.4.19.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26158264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage gamma-polyglutamate hydrolase" /protein_id="NP_389665.1" /db_xref="EnsemblGenomes-Gn:BSU17820" /db_xref="EnsemblGenomes-Tr:CAB13666" /db_xref="GOA:O31815" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13448" /db_xref="UniProtKB/Swiss-Prot:O31815" /translation="MKPAKVSLLRRLLHSLKHVDCNIAKRFPSTIKIVKLLMIFMVFT PISSIYAEDVYQNFEELKNNEDPSDYGVVTKETGSPVLVLAIHGGGIEGGTSEVAREL SKEYSMYLFEGLKSAGNSVLHITSTHFDEPRALKMTGNHEYVISLHGYAEEDQQIEVG GTDRVRAADLVEKLQHAGFPAVLLNMDHPHAGVSPNNIANKSKTGLSIQIEMSTGFRK SLFGIFSLKSRAVTQNERFYEFTEVMFRFLKNSY*" /label="pghL CDS" gene 1631207..1631965 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /label="pghL gene" upshifts 1631240 /Source="Nicolas_upshifts" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1631256..1631275) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1631257) /Source="Nicolas_upshifts" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1631290..1631297) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1631780..1631991) /Source="Nicolas_S_feature" /locus_tag="new_1915794_1916005_c" /HighExp="S8, S5, S7, S6, S4, ferm, nit, BT, Pyr, G/S" /AntisenseName="yndL" /AntisenseCor="0.82198535504067005" /AntisenseRegPval="-66.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.515" /TUlongSig="NA" /TUlongPSig="NA" /label="S656" downshifts 1631944 /Source="Nicolas_upshifts" /id="D972" /incds=0 /nref=3 /ntot=23 /MaxReadThrough="4.17889" /MaxDrop="5.0493" /score="15.340233" /energy="-10.4" /TU="U1428,U1430" /idTUdmin="U1428" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" S_feature 1631989..1632608 /Source="Nicolas_S_feature" /locus_tag="new_1916003_1916622" /HighExp="S8, S6, S7, S5, C30, BT, G135, LBGstat, GM 150, M/G" /AntisenseName="yndM" /AntisenseCor="0.75549671487088998" /AntisenseRegPval="-50.2" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S657" CDS complement(1631992..1632531) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389666.1" /db_xref="EnsemblGenomes-Gn:BSU17830" /db_xref="EnsemblGenomes-Tr:CAB13667" /db_xref="GOA:O31816" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG13449" /db_xref="UniProtKB/Swiss-Prot:O31816" /translation="MTIMNGFELHYLSFVYAQEFSSKNNNLGGQMKHIIALASKIAFT LALLYVILDRVYHASFLSVMFIALFLGFVSYLSGDMLVLPRTNNITASLADFGLSFVI LWVFVLTQTRNDFSPFGAALLSAACLTVFEYFFHRYLLKNVLDENFRNELSARDNTLQ YQTEAADELFPETKEKHKE*" /label="yndM CDS" gene complement(1631992..1632531) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /label="yndM gene" promotor_-10 complement(1632532..1632546) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1632538) /Source="Nicolas_upshifts" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1632560..1632566) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1632586..1632595 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1632608..1632623 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1632610 /Source="Nicolas_upshifts" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" CDS 1632649..1633083 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /EC_number="2.5.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11244082, 16399398, 19763274, 23256780" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244082, 16399398, 19763274, 23256780; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="magnesium-dependent bacillithiol-transferase" /protein_id="NP_389667.1" /db_xref="EnsemblGenomes-Gn:BSU17840" /db_xref="EnsemblGenomes-Tr:CAB13668" /db_xref="GOA:O31817" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR022858" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13450" /db_xref="UniProtKB/Swiss-Prot:O31817" /translation="MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMN GIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDR KSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF*" /label="fosB CDS" gene 1632649..1633083 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /label="fosB gene" CDS 1632941..1633288 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27144405" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513960.1" /translation="MNAIENQFILPTLTATNLNFIPEPFKTGFDITNKKKRICTFMMK RPFDSTTIFHIRLNLKKGVGGDFMFGEGFYPTCSTMPYLLNCTSDWVKVKLKYTLHYI LYEESELFYQMLN*" /label="yzzP CDS" gene 1632941..1633288 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /label="yzzP gene" S_feature 1633084..1633416 /Source="Nicolas_S_feature" /locus_tag="new_1917098_1917430" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T0.0H, T-1.10H, T2.30H, Salt, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.66836499999999999" /TUshortSig="SigWXY, Sig-, SigK" /TUshortPSig="1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S658" promotor_-35 1633375..1633384 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1633396..1633411 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1633418..1633596 /Source="Nicolas_S_feature" /locus_tag="new_1917432_1917610" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T-1.10H, T0.0H, T2.30H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigWXY, Sig-, SigK" /TUshortPSig="0.99, 1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S659" upshifts 1633418 /Source="Nicolas_upshifts" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1633487..1633566 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /product="putative conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="ncrF RNA" gene 1633487..1633566 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /label="ncrF gene" downshifts 1633553 /Source="Nicolas_upshifts" /id="D973" /incds=0 /nref=16 /ntot=188 /MaxReadThrough="2.99425" /MaxDrop="4.30173" /score="-1.31226475" /energy="-14.3" /TU="U1433" /idTUdmin="U1434" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1633625..1634242) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the SOS regulon" /protein_id="NP_389668.1" /db_xref="EnsemblGenomes-Gn:BSU17850" /db_xref="EnsemblGenomes-Tr:CAB13669" /db_xref="GOA:P31080" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10678" /db_xref="UniProtKB/Swiss-Prot:P31080" /translation="MTKLSKRQLDILRFIKAEVKSKGYPPSVREIGEAVGLASSSTVH GHLARLETKGLIRRDPTKPRAIEILDEEVDIPQSQVVNVPVIGKVTAGSPITAVENIE EYFPLPDRMVPPDEHVFMLEIMGDSMIDAGILDKDYVIVKQQNTANNGEIVVAMTEDD EATVKRFYKEDTHIRLQPENPTMEPIILQNVSILGKVIGVFRTVH*" /label="lexA CDS" gene complement(1633625..1634242) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /label="lexA gene" downshifts complement(1633626) /Source="Nicolas_upshifts" /id="D974" /incds=0 /nref=186 /ntot=254 /MaxReadThrough="2.74616" /MaxDrop="7.90985" /score="8.16083322" /energy="-16.3" /TU="U1435" /idTUdmin="U1435" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1634266..1634285) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1634287) /Source="Nicolas_upshifts" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1634299..1634306) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1634322..1634329 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1634341 /Source="Nicolas_upshifts" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1634343..1634362 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1634392..1634709 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12581363, 16267290, 16549676, 20400548, 20807205, 23728628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12581363, 16267290, 16549676, 20400548, 20807205, 23728628; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="NP_389669.1" /db_xref="EnsemblGenomes-Gn:BSU17860" /db_xref="EnsemblGenomes-Tr:CAB13670" /db_xref="GOA:Q45056" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR022887" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11820" /db_xref="UniProtKB/Swiss-Prot:Q45056" /translation="MIMSKESIIFVGLFTVILSAVILMLSYTSSGQELNQYVKIEVQQ GDTLWSIADQVADTKKINKNDFIEWVADKNQLQTSDIQPGDELVIPLKKKHQDAYELA TVR*" /label="dinK CDS" gene 1634392..1634709 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /label="dinK gene" promotor_-10 complement(1634409..1634427) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1634412) /Source="Nicolas_upshifts" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1634441..1634448) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1634728..1635381 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /function="16.9: Replicate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12581363, 16267290, 17020588, 19060143, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase, resolvase" /protein_id="NP_389670.1" /db_xref="EnsemblGenomes-Gn:BSU17870" /db_xref="EnsemblGenomes-Tr:CAB13671" /db_xref="GOA:Q45057" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG11821" /db_xref="UniProtKB/Swiss-Prot:Q45057" /translation="MKALIYARVSTNKEQQETSLKRQEEELTAIAAENGMEVVKVISE KASGYEMDRDGVFELLDEIKNADIDVILVQDETRLGRGNAKIALLHCIYREGVKVYTT AHRGELELSEADSMVLEIVSIVEEYQRKIHNMKIRRGMKRAVKNGFKPQKNLKNQHGN SGKEKIEVPISEIVRLRANKLTFAEIAATLRGFGYDVSKATVHRRFQEYIENEETAE* " /label="dinL CDS" gene 1634728..1635381 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /label="dinL gene" promotor_-35 1635384..1635391 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-35" promotor_-10 1635405..1635424 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-10" upshifts 1635418 /Source="Nicolas_upshifts" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="upshifts" CDS 1635445..1635678 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12581363, 16267290, 18431750,19306341, 22333191, 22933559, 23099262" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389671.1" /db_xref="EnsemblGenomes-Gn:BSU17880" /db_xref="EnsemblGenomes-Tr:CAB13672" /db_xref="GOA:O31818" /db_xref="InterPro:IPR009242" /db_xref="PDB:2HEP" /db_xref="PDB:2JVD" /db_xref="PDB:3BHP" /db_xref="SubtiList:BG13466" /db_xref="UniProtKB/Swiss-Prot:O31818" /translation="MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSS MKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH*" /label="ynzC CDS" gene 1635445..1635678 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /label="ynzC gene" S_feature 1635679..1635814 /Source="Nicolas_S_feature" /locus_tag="new_1919693_1919828" /HighExp="M40t90, M40t45, dia15, C90, Etha, H2O2, T5.0H, Salt, dia5, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S660" promotor_-35 1635782..1635789 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-35" promotor_-10 1635803..1635822 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-10" upshifts 1635816 /Source="Nicolas_upshifts" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="upshifts" CDS 1635847..1637850 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /EC_number="2.2.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696621, 12682299, 12882400, 27739585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696621, 12682299, 12882400, 27739585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transketolase" /protein_id="NP_389672.1" /db_xref="EnsemblGenomes-Gn:BSU17890" /db_xref="EnsemblGenomes-Tr:CAB13673" /db_xref="GOA:P45694" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033247" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11247" /db_xref="UniProtKB/Swiss-Prot:P45694" /translation="MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTK FMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHP EFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVED GNNIEELTAAIEKARQNEKKPTLIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKE AYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKEVYPELAEQLELAIK GELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNA GDFTAVDYSGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAAL MGLPVTYVFTHDSIAVGEDGPTHEPVEQLASLRAMPNLSLIRPADGNETAAAWKLAVQ STDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASGSEVGLA IEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKY TGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNRVKALINK*" /label="tktA CDS" gene 1635847..1637850 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /label="tktA gene" misc_feature complement(1636051..1636070) /Source="Nicolas_upshift_promotors" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1636068) /Source="Nicolas_upshifts" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1637840 /Source="Nicolas_upshifts" /id="D975" /incds=0 /nref=230 /ntot=257 /MaxReadThrough="4.5478" /MaxDrop="6.66676" /score="16.4587041" /energy="-10.6" /TU="U1439" /idTUdmin="U1436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1637852..1638510) /Source="Nicolas_S_feature" /locus_tag="new_1921866_1922524_c" /HighExp="Lbstat, C30, Salt, BC, S7, LPhT, S8, M0t90, T-0.40H, Glucon" /AntisenseName="yneE" /AntisenseCor="4.3891878649396997E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.604, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S661" upshifts 1637950 /Source="Nicolas_upshifts" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="upshifts" misc_feature 1637951..1637970 /Source="Nicolas_upshift_promotors" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1638003..1638449 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /experiment="publication(s) with functional evidences, PMID:19682252, 25041308, 22720735, 27489185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682252, 25041308, 22720735, 27489185; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor controlling DNA replication" /protein_id="NP_389673.1" /db_xref="EnsemblGenomes-Gn:BSU17900" /db_xref="EnsemblGenomes-Tr:CAB13674" /db_xref="GOA:P45707" /db_xref="InterPro:IPR019683" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG11248" /db_xref="UniProtKB/Swiss-Prot:P45707" /translation="MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEM TEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIE IVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV*" /label="pcfA CDS" gene 1638003..1638449 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /label="pcfA gene" misc_feature 1638473..1638492 /Source="Nicolas_upshift_promotors" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1638481 /Source="Nicolas_upshifts" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1638492..1638509) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1638510) /Source="Nicolas_upshifts" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1638528..1638532) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1638535..1638753 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389674.1" /db_xref="EnsemblGenomes-Gn:BSU17910" /db_xref="EnsemblGenomes-Tr:CAB13675" /db_xref="GOA:P45708" /db_xref="InterPro:IPR005359" /db_xref="SubtiList:BG11249" /db_xref="UniProtKB/Swiss-Prot:P45708" /translation="MTLWVGILVGVVALLIGVALGFFIARKYMMSYLKKNPPINEQML RMMMMQMGMKPSQKKINQMMKAMNNQTK*" /label="yneF CDS" gene 1638535..1638753 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /label="yneF gene" downshifts 1638765 /Source="Nicolas_upshifts" /id="D976" /incds=0 /nref=243 /ntot=260 /MaxReadThrough="3.51446" /MaxDrop="7.54782" /score="0.133420982" /energy="-4.3" /TU="U1441,U1442" /idTUdmin="U1439" /TUdmin=287 /isTUend="FALSE" /label="downshifts" S_feature 1638810..1639109 /Source="Nicolas_S_feature" /locus_tag="new_1922824_1923123" /HighExp="S4, S3, S5, G180, S8, T5.0H, LoTm, G135, S6, S7" /AntisenseName="ynzD" /AntisenseCor="-0.33023056016157298" /AntisenseRegPval="-7.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S662" CDS complement(1638827..1639000) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 15187183, 17350627, 22303282, 23378509, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 15187183, 17350627, 22303282, 23378509, 27965289; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase" /protein_id="NP_389675.1" /db_xref="EnsemblGenomes-Gn:BSU17920" /db_xref="EnsemblGenomes-Tr:CAB13676" /db_xref="GOA:O31819" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13467" /db_xref="UniProtKB/Swiss-Prot:O31819" /translation="MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQ YQKQRLRAVAGDE*" /label="spo0D CDS" gene complement(1638827..1639000) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /label="spo0D gene" downshifts complement(1638840) /Source="Nicolas_upshifts" /id="D977" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="4.0851" /MaxDrop="5.22565" /score="1.92055758" /energy="-4.3" /TU="U1444,U1446" /idTUdmin="U1444" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1639038..1639057) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1639045) /Source="Nicolas_upshifts" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1639071..1639078) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1639080..1639088 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1639100..1639119) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1639100..1639118 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1639111..1639219 /Source="Nicolas_S_feature" /locus_tag="new_1923125_1923233" /HighExp="T4.0H, T3.30H, T3.0H, S2, Lbstat, T5.0H, T2.30H, S4, T-1.40H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA, SigA" /TUshortPSig="0.999, 1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S663" upshifts 1639111 /Source="Nicolas_upshifts" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1639112) /Source="Nicolas_upshifts" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1639134..1639141) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1639220..1639927 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /function="16.10: Respire" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16771673, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16771673, 16850406, 19682263; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome c-type biogenesis protein CcdA; thiol-disulfide oxido-reductase" /protein_id="NP_389676.1" /db_xref="EnsemblGenomes-Gn:BSU17930" /db_xref="EnsemblGenomes-Tr:CAB13677" /db_xref="GOA:P45706" /db_xref="InterPro:IPR003834" /db_xref="SubtiList:BG11240" /db_xref="UniProtKB/Swiss-Prot:P45706" /translation="MGDVNYFLTFGAGFLSFISPCCLPLYPAFLSYITGVSMDDVKTE KLLLQKRSLFHTLCFLLGFSVIFIALGYGTSFIGSLFRDYHDAIRQIGALLIILFGFI TLGVFRPEAMMKERRIHFKHKPSGFLGSVLIGMAFAAGWTPCTGPILAAVITLAGTNP GSAVPYMMLYVLGFAVPFLLLSFFITKLKWIRKNQLFIMKAGGVLMIVIGVLLFFNWM SLIIILLSDLFGGFTGF*" /label="ccdA CDS" gene 1639220..1639927 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /label="ccdA gene" promotor_-35 1639947..1639954 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1639966..1639985 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1639974 /Source="Nicolas_upshifts" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1640016..1640378 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative response regulator (CheY homolog)" /protein_id="NP_389677.1" /db_xref="EnsemblGenomes-Gn:BSU17940" /db_xref="EnsemblGenomes-Tr:CAB13678" /db_xref="GOA:P45709" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11250" /db_xref="UniProtKB/Swiss-Prot:P45709" /translation="MTRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKK LRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIV KPFEETKVLEAVSRVMGH*" /label="yneI CDS" gene 1640016..1640378 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /label="yneI gene" promotor_-35 1640396..1640399 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1640414..1640433 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1640425 /Source="Nicolas_upshifts" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1640457..1640948 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389678.1" /db_xref="EnsemblGenomes-Gn:BSU17950" /db_xref="EnsemblGenomes-Tr:CAB13679" /db_xref="GOA:P45710" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR031306" /db_xref="SubtiList:BG11251" /db_xref="UniProtKB/Swiss-Prot:P45710" /translation="MISMMIIVSSIIAVLMAVAVMVVRIKSSDKPVSPKKIILPPIFM STGALMFLFPVFWVTGAEFLEAFTLGVIFSIFLIKTSKFEIKNNEIYMKRSKAFVFIL VGLLVIRIVMKSILSTSIDYGALSGMFWILAFGMIVPWRIAMYLSYRKLHNELQSSNI QMN*" /label="yneJ CDS" gene 1640457..1640948 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /label="yneJ gene" downshifts 1640944 /Source="Nicolas_upshifts" /id="D978" /incds=0 /nref=110 /ntot=273 /MaxReadThrough="1.09905" /MaxDrop="5.9692" /score="16.4219082" /energy="-9.7" /TU="NA" /idTUdmin="U1445" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1640979..1641407) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DynA" /protein_id="NP_389679.1" /db_xref="EnsemblGenomes-Gn:BSU17960" /db_xref="EnsemblGenomes-Tr:CAB13680" /db_xref="InterPro:IPR020203" /db_xref="SubtiList:BG11252" /db_xref="UniProtKB/Swiss-Prot:P45711" /translation="MLEGWFLWFILFWVIMMVVLLSIGGFFMFRKFLKRLPKEDGRSE LDWQDYYIENSRHLWNDENKQFLDELTAPVPELFRDAAKAKIAGKIGELALKEKVAKI DQQLMIKGYILATPKRDHTFLKRHLRDKKIDLEPYQTLLK*" /label="yneK CDS" gene complement(1640979..1641407) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /label="yneK gene" downshifts complement(1640996) /Source="Nicolas_upshifts" /id="D979" /incds=0 /nref=188 /ntot=245 /MaxReadThrough="1.60911" /MaxDrop="5.09033" /score="10.710816" /energy="-9.7" /TU="NA" /idTUdmin="U1449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1641425..1641444) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1641437) /Source="Nicolas_upshifts" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1641439..1641524) /Source="Nicolas_S_feature" /locus_tag="new_1925453_1925538_c" /HighExp="S8, S6, S7, LBGstat, C30, dia15, S0, Cold, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.958, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S664" promotor_-35 complement(1641458..1641465) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1641495..1641504 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1641514..1641623 /Source="Nicolas_S_feature" /locus_tag="new_1925528_1925637" /HighExp="S8, BT, B36, S7, G/S, Pyr, B60, S6, Glucon, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S665" upshifts 1641514 /Source="Nicolas_upshifts" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1641517..1641536 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1641519..1641538) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1641524) /Source="Nicolas_upshifts" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1641526..1641609) /Source="Nicolas_S_feature" /locus_tag="new_1925540_1925623_c" /HighExp="S8, S6, S7, C30, BT, S5, Pyr, Glucon, BC, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S666" promotor_-35 complement(1641553..1641556) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1641580 /Source="Nicolas_upshifts" /id="D980" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="3.76639" /MaxDrop="5.34013" /score="5.70696998" /energy="-12.7" /TU="U1450" /idTUdmin="U1450" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1641641..1642033) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9068633, 11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068633, 11150673; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389680.1" /db_xref="EnsemblGenomes-Gn:BSU17970" /db_xref="EnsemblGenomes-Tr:CAB13681" /db_xref="GOA:Q45058" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11822" /db_xref="UniProtKB/Swiss-Prot:Q45058" /translation="MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDL YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQV ECENQILTVAVNKETEDGSSFSLQFPLS*" /label="cotM CDS" gene complement(1641641..1642033) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /label="cotM gene" downshifts complement(1641654) /Source="Nicolas_upshifts" /id="D981" /incds=0 /nref=20 /ntot=92 /MaxReadThrough="4.44864" /MaxDrop="4.9615" /score="11.5991121" /energy="-12.7" /TU="U1454" /idTUdmin="U1456" /TUdmin=486 /isTUend="FALSE" /label="downshifts" promotor_-35 1641876..1641881 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-35" promotor_-10 1641897..1641915 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-10" upshifts 1641901 /Source="Nicolas_upshifts" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="upshifts" promotor_-35 1642011..1642015 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1642025..1642039 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1642040..1642059) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1642042 /Source="Nicolas_upshifts" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1642055) /Source="Nicolas_upshifts" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1642073..1642082) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1642114..1642260) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389681.1" /db_xref="EnsemblGenomes-Gn:BSU17980" /db_xref="EnsemblGenomes-Tr:CAB13682" /db_xref="GOA:P71032" /db_xref="InterPro:IPR012614" /db_xref="SubtiList:BG11921" /db_xref="UniProtKB/Swiss-Prot:P71032" /translation="MTNKNTSKDMHKNAPKGHNPGQPEPLSGSKKVKNRNHTRQKHNS SHDM*" /label="sspP CDS" gene complement(1642114..1642260) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /label="sspP gene" downshifts complement(1642135) /Source="Nicolas_upshifts" /id="D982" /incds=0 /nref=42 /ntot=61 /MaxReadThrough="1.80349" /MaxDrop="6.88836" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1456" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1642292..1642438) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018, 10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018, 10806362; Product type s: structure" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389682.1" /db_xref="EnsemblGenomes-Gn:BSU17990" /db_xref="EnsemblGenomes-Tr:CAB13683" /db_xref="GOA:P71031" /db_xref="InterPro:IPR012613" /db_xref="SubtiList:BG11920" /db_xref="UniProtKB/Swiss-Prot:P71031" /translation="MVKRKANHVINGMNDAKSQGKGAGYIENDQLVLTEAERQNNKKR KTNQ*" /label="sspO CDS" gene complement(1642292..1642438) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /label="sspO gene" S_feature 1642438..1642571 /Source="Nicolas_S_feature" /locus_tag="new_1926452_1926585" /HighExp="S8, S7, S3, S6, LoTm, S4, S5, BT, Pyr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S667" upshifts 1642438 /Source="Nicolas_upshifts" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1642449..1642451 /Source="Nicolas_upshift_promotors" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(1642454..1642465) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1642468) /Source="Nicolas_upshifts" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1642480..1642486) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1642561..1642568 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1642573..1642665 /Source="Nicolas_S_feature" /locus_tag="new_1926587_1926679" /HighExp="B60, M40t90, T0.0H, HiOs, T4.0H, T5.0H, T2.30H, M0t90, Sw, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S668" upshifts 1642573 /Source="Nicolas_upshifts" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1642583..1642602 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1642624) /Source="Nicolas_upshifts" /id="D983" /incds=0 /nref=1 /ntot=67 /MaxReadThrough="2.77282" /MaxDrop="4.02811" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1458" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1642666..1645395 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /EC_number="4.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate hydratase (bifunctional aconitase)" /protein_id="NP_389683.1" /db_xref="EnsemblGenomes-Gn:BSU18000" /db_xref="EnsemblGenomes-Tr:CAB13684" /db_xref="GOA:P09339" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006249" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG10478" /db_xref="UniProtKB/Swiss-Prot:P09339" /translation="MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSK LPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVP AVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERN AERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGT DSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLAL KVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYL RLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLI PLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSC TNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELG FNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLAS PPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRK EYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVG KFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANI RIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAA KGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDET VRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS*" /label="citB CDS" gene 1642666..1645395 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /label="citB gene" misc_feature complement(1642686..1642690) /Source="Nicolas_upshift_promotors" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1642690) /Source="Nicolas_upshifts" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1645396..1645466 /Source="Nicolas_S_feature" /locus_tag="new_1929410_1929480" /HighExp="M9-stat, B60, M40t90, Glucon, M0t90, MG-0.2, Mal, T2.30H, MG-0.1, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S669" CDS 1645467..1645979 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15342593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane-bound proteins with a thioredoxin-like domain" /protein_id="NP_389684.1" /db_xref="EnsemblGenomes-Gn:BSU18010" /db_xref="EnsemblGenomes-Tr:CAB13685" /db_xref="GOA:O31820" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13451" /db_xref="UniProtKB/Swiss-Prot:O31820" /translation="MLKKWLAGILLIMLVGYTGWNLYQTYSKKEVGIQEGQQAPDFSL KTLSGEKSSLQDAKGKKVLLNFWATWCKPCRQEMPAMEKLQKEYADKLAVVAVNFTSA EKSEKQVRAFADTYDLTFPILIDKKGINADYNVMSYPTTYILDEKGVIQDIHVGTMTK KEMEQKLDLD*" /label="yneN CDS" gene 1645467..1645979 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /label="yneN gene" downshifts 1645936 /Source="Nicolas_upshifts" /id="D984" /incds=0 /nref=115 /ntot=218 /MaxReadThrough="3.76369" /MaxDrop="5.09954" /score="13.5401842" /energy="-6.9" /TU="U1457" /idTUdmin="U1457" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-35 1646005..1646011 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1646024 /Source="Nicolas_upshifts" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1646026..1646037 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1646060..1646185 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097732.1" /db_xref="EnsemblGenomes-Gn:BSU18019" /db_xref="EnsemblGenomes-Tr:CAX52626" /db_xref="InterPro:IPR025004" /db_xref="UniProtKB/Swiss-Prot:C0H418" /translation="MKKMRKRSFHELVMENKKELMTNTEYLNQLEEKLEQRFKQK*" /label="ynzL CDS" gene 1646060..1646185 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /label="ynzL gene" downshifts complement(1646078) /Source="Nicolas_upshifts" /id="D985" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.12259" /MaxDrop="3.48183" /score="-0.0160782027" /energy="-13.9" /TU="NA" /idTUdmin="U1462" /TUdmin=1298 /isTUend="FALSE" /label="downshifts" promotor_-35 1646199..1646205 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1646220..1646231 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1646222 /Source="Nicolas_upshifts" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" CDS 1646250..1646396 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054579.2" /db_xref="EnsemblGenomes-Gn:BSU18020" /db_xref="EnsemblGenomes-Tr:CAE01455" /db_xref="GOA:Q7WY69" /db_xref="InterPro:IPR012612" /db_xref="SubtiList:BG14179" /db_xref="UniProtKB/Swiss-Prot:Q7WY69" /translation="MGNNKKNGQPQYAPSHLGTKPVKYKANKGEKMHDTSGQRPIIMQ TKGE*" /label="sspN CDS" gene 1646250..1646396 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /label="sspN gene" CDS 1646433..1646684 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (thioredoxin-like protein)" /protein_id="NP_389685.1" /db_xref="EnsemblGenomes-Gn:BSU18030" /db_xref="EnsemblGenomes-Tr:CAB13686" /db_xref="GOA:Q45060" /db_xref="InterPro:IPR017524" /db_xref="SubtiList:BG11806" /db_xref="UniProtKB/Swiss-Prot:Q45060" /translation="MTKNQNQYQQPNPDDRSDNVEKLQDMVQNTIENIEEAEASMEFA SGEDKQRIKEKNARREQSIEAFRNEIQDESAARQNGYRS*" /label="sspT CDS" gene 1646433..1646684 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /label="sspT gene" downshifts 1646662 /Source="Nicolas_upshifts" /id="D986" /incds=0 /nref=41 /ntot=49 /MaxReadThrough="2.07653" /MaxDrop="7.06685" /score="32.1193211" /energy="-7" /TU="NA" /idTUdmin="U1457" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1646705..1646710 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1646724..1646743 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1646728..1646819 /Source="Nicolas_S_feature" /locus_tag="new_1930742_1930833" /HighExp="Etha, dia5, dia15, Diami, H2O2, G180, Salt, G150, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S670" upshifts 1646728 /Source="Nicolas_upshifts" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1646820..1647185 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /EC_number="3.1.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11959124, 11994151, 16294310, 18338382; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA thioesterase" /protein_id="YP_054580.1" /db_xref="EnsemblGenomes-Gn:BSU18040" /db_xref="EnsemblGenomes-Tr:CAB13687" /db_xref="GOA:Q45061" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR006684" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11823" /db_xref="UniProtKB/Swiss-Prot:Q45061" /translation="MGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDIN ISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKP IQFRKAFPDWHTAYEKAKK*" /label="yneP CDS" gene 1646820..1647185 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /label="yneP gene" CDS 1647201..1647500 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389687.1" /db_xref="EnsemblGenomes-Gn:BSU18050" /db_xref="EnsemblGenomes-Tr:CAB13688" /db_xref="SubtiList:BG11824" /db_xref="UniProtKB/Swiss-Prot:Q45062" /translation="MAFGVKREELNRWKQAVKRGEIAFLTHYWLDDRFPEAKTVTKAG CADIDKLVQWGAAYGLKKEWIHKKSEFPHFDLLGETQKYILEQENLTDHLIRFHL*" /label="yneQ CDS" gene 1647201..1647500 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /label="yneQ gene" downshifts 1647476 /Source="Nicolas_upshifts" /id="D987" /incds=0 /nref=55 /ntot=217 /MaxReadThrough="3.04989" /MaxDrop="5.5978" /score="-4.41102273" /energy="-6" /TU="NA" /idTUdmin="U1461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1647531..1647818) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 23176286" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389688.1" /db_xref="EnsemblGenomes-Gn:BSU18060" /db_xref="EnsemblGenomes-Tr:CAB13689" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR008326" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11825" /db_xref="UniProtKB/Swiss-Prot:Q45063" /translation="MNMTINEDALNWYKEELDLESGDQVRFFVRYGGCSNVQKGFSLG VAKDAPQEAGVTAEADGITFFIEESDLWYFDNHDLLVSYSEDADEPVFEYQ*" /label="yneR CDS" gene complement(1647531..1647818) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /label="yneR gene" downshifts complement(1647552) /Source="Nicolas_upshifts" /id="D988" /incds=0 /nref=216 /ntot=260 /MaxReadThrough="3.77766" /MaxDrop="7.20006" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(1647618) /Source="Nicolas_upshifts" /id="D989" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.5674" /MaxDrop="3.11178" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1647848..1647867) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1647860) /Source="Nicolas_upshifts" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1647883..1647890) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1647906..1648487) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphate:glycerol-3-phosphate O-acyltransferase" /protein_id="NP_389689.1" /db_xref="EnsemblGenomes-Gn:BSU18070" /db_xref="EnsemblGenomes-Tr:CAB13690" /db_xref="GOA:Q45064" /db_xref="InterPro:IPR003811" /db_xref="SubtiList:BG11826" /db_xref="UniProtKB/Swiss-Prot:Q45064" /translation="MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNA FRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGG KAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYL LIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL*" /label="plsY CDS" gene complement(1647906..1648487) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /label="plsY gene" S_feature 1648488..1648618 /Source="Nicolas_S_feature" /locus_tag="new_1932502_1932632" /HighExp="C30, S8, S7, S5, S6, S4, BC, S3, T4.0H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S671" misc_feature complement(1648513..1648532) /Source="Nicolas_upshift_promotors" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1648530) /Source="Nicolas_upshifts" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1648603..1648606 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1648620 /Source="Nicolas_upshifts" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1648622..1648641 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1648657..1649064 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA-binding protein" /protein_id="NP_389690.1" /db_xref="EnsemblGenomes-Gn:BSU18080" /db_xref="EnsemblGenomes-Tr:CAB13691" /db_xref="GOA:Q45065" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11827" /db_xref="UniProtKB/Swiss-Prot:Q45065" /translation="MQNPSKAEIKEILQRSKRIAVVGLSDRPDRTSHMVSKAMQDAGY EIIPVNPTIDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAPVFWAQ QGLVNEEAYQMLKEKGRTVIMDLCIKVAHAVTK*" /label="yneT CDS" gene 1648657..1649064 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /label="yneT gene" downshifts 1649060 /Source="Nicolas_upshifts" /id="D990" /incds=0 /nref=63 /ntot=221 /MaxReadThrough="4.35976" /MaxDrop="5.49229" /score="-2.11194139" /energy="-6" /TU="U1464" /idTUdmin="U1461" /TUdmin=1584 /isTUend="FALSE" /label="downshifts" promotor_-35 1649126..1649129 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1649144..1649163 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1649148..1649462 /Source="Nicolas_S_feature" /locus_tag="new_1933162_1933476" /HighExp="H2O2, G150, G180, Etha, Oxctl, LBGexp, dia0, Lbexp, M40t45, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S672" upshifts 1649148 /Source="Nicolas_upshifts" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" CDS 1649463..1651430 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8969507, 9539793, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8969507, 9539793, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit B of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389691.2" /db_xref="EnsemblGenomes-Gn:BSU18090" /db_xref="EnsemblGenomes-Tr:CAB13692" /db_xref="GOA:Q59192" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005740" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11804" /db_xref="UniProtKB/Swiss-Prot:Q59192" /translation="MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVY EIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHA GGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKI GKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVF YYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRT KDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQ FEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAR EEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLP LRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGA HIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKK VGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEP RRKWIEKNVAFGLDEESNILENENLSVAEEV*" /label="parE CDS" gene 1649463..1651430 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /label="parE gene" CDS 1651434..1653854 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9539793, 12682299, 16267290, 16272394, 24440393" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9539793, 12682299, 16267290, 16272394, 24440393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit A of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389692.2" /db_xref="EnsemblGenomes-Gn:BSU18100" /db_xref="EnsemblGenomes-Tr:CAB13693" /db_xref="GOA:Q45066" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005741" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="SubtiList:BG11803" /db_xref="UniProtKB/Swiss-Prot:Q45066" /translation="MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQ RRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLI EMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPT GGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMD EFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVA IHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVI ATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIE ELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVT VTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVH QLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHY KAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAG VKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELK KNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTA VWRLHTEQ*" /label="parC CDS" gene 1651434..1653854 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /label="parC gene" downshifts 1653834 /Source="Nicolas_upshifts" /id="D991" /incds=0 /nref=227 /ntot=255 /MaxReadThrough="0.556700000000001" /MaxDrop="5.87714" /score="9.15080033" /energy="-14.6" /TU="NA" /idTUdmin="U1465" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1653862..1654051) /Source="Nicolas_S_feature" /locus_tag="new_1937876_1938065_c" /HighExp="LPhT, B60, Etha, B36, Gly, LoTm, Sw, BC, S8, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99806099999999998" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="0.968, 0.994, 0.642" /TUlongSig="NA" /TUlongPSig="NA" /label="S673" CDS complement(1653901..1654077) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (C-terminus)" /db_xref="PSEUDO:SOX90559.1" /translation="MFNITRLCNENMRRLLNMLFILRMVILGLFSFTALNLFVWQGIE VIHAVTDLFTNHES*" /label="ynfCc CDS" gene complement(1653901..1654077) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /pseudo /label="ynfCc gene" downshifts complement(1653905) /Source="Nicolas_upshifts" /id="D992" /incds=0 /nref=153 /ntot=267 /MaxReadThrough="0.609599999999999" /MaxDrop="7.72532" /score="38.0779167" /energy="-14.6" /TU="NA" /idTUdmin="U1467" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1654052..1654462) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU18110" /db_xref="EnsemblGenomes-Tr:CAB13694" /db_xref="GOA:Q45067" /db_xref="PSEUDO:CAB13694.1" /db_xref="SubtiList:BG11828" /db_xref="UniProtKB/Swiss-Prot:Q45067" /translation="MDWGIIIKIFSNIKGGGDHLKKVTILKASILFLAIASFHLFSIP HAFDIGHHYKAVADQQEMHEMKAGQNADDEKKSITGAFTLTALWAMAVLLLTAESKST GYSRRRQRKKSFILAKFYQSSYFGKLHVQHHPIM*" /label="ynfCn CDS" gene complement(1654052..1654462) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /pseudo /label="ynfCn gene" promotor_-10 complement(1654435..1654454) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1654438) /Source="Nicolas_upshifts" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1654469..1654476) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1654503..1654522) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1654504) /Source="Nicolas_upshifts" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1654537..1654544) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1654551..1654570) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1654562) /Source="Nicolas_upshifts" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1654584..1654593) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1654810..1654815 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1654828..1654847 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1654833 /Source="Nicolas_upshifts" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="upshifts" S_feature 1654846..1654910 /Source="Nicolas_S_feature" /locus_tag="new_1938860_1938924" /HighExp="Cold, G180, Oxctl, G135, LBGexp, G150, HPh, dia0, Lbexp, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S674" CDS 1654911..1656308 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8969507, 12823818, 15849754, 16850406, 22607086; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+/Na+:nitrogen-donor aminoacid symporter" /protein_id="NP_389694.1" /db_xref="EnsemblGenomes-Gn:BSU18120" /db_xref="EnsemblGenomes-Tr:CAB13695" /db_xref="GOA:Q45068" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG11798" /db_xref="UniProtKB/Swiss-Prot:Q45068" /translation="MESFFNSLINIPSDFIWKYLFYILIGLGLFFTIRFGFIQFRYFI EMFRIVGEKPEGNKGVSSMQAFFISAASRVGTGNLTGVALAIATGGPGAVFWMWVVAA VGMASSFVESTLAQLYKVRDGEDFRGGPAYYIQKGLGARWLGIVFAILITVSFGLIFN AVQTNTIAGALDGAFHVNKIVVAIVLAVLTAFIIFGGLKRVVAVSQLIVPVMAGIYIL IALFVVITNITAFPGVIATIVKNALGFEQVVGGGIGGIIVIGAQRGLFSNEAGMGSAP NAAATAHVSHPAKQGFIQTLGVFFDTFIICTSTAFIILLYSVTPKGDGIQVTQAALNH HIGGWAPTFIAVAMFLFAFSSVVGNYYYGETNIEFIKTSKTWLNIYRIAVIAMVVYGS LSGFQIVWDMADLFMGIMALINLIVIALLSNVAYKVYKDYAKQRKQGLDPVFKAKNIP GLKNAETWEDEKQEA*" /label="alsT CDS" gene 1654911..1656308 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /label="alsT gene" downshifts 1656297 /Source="Nicolas_upshifts" /id="D993" /incds=0 /nref=112 /ntot=203 /MaxReadThrough="3.44078" /MaxDrop="5.75319" /score="16.664707" /energy="-14.7" /TU="U1469" /idTUdmin="U1469" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 1656342 /Source="Nicolas_upshifts" /id="D994" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.22962" /MaxDrop="5.03444" /score="16.664707" /energy="-14.7" /TU="NA" /idTUdmin="U1469" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(1656398..1657144) /Source="Nicolas_S_feature" /locus_tag="new_1940412_1941158_c" /HighExp="S6, S8, S7, S5, BT, C30, B36, S4, LoTm, B60" /AntisenseName="eglS" /AntisenseCor="0.42607634596628102" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S675" promotor_-35 1656521..1656528 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1656540 /Source="Nicolas_upshifts" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1656541..1656560 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1656611..1658110 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /EC_number="3.2.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3024130, 7704256, 7710279, 15139916, 26907762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3024130, 7704256, 7710279, 15139916, 26907762; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-1,4-beta-glucanase" /protein_id="NP_389695.2" /db_xref="EnsemblGenomes-Gn:BSU18130" /db_xref="EnsemblGenomes-Tr:CAB13696" /db_xref="GOA:P10475" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR008965" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018087" /db_xref="InterPro:IPR036966" /db_xref="PDB:2L8A" /db_xref="PDB:3PZT" /db_xref="PDB:3PZU" /db_xref="PDB:3PZV" /db_xref="SubtiList:BG10437" /db_xref="UniProtKB/Swiss-Prot:P10475" /translation="MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSI KGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGY IDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTP NVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQ LKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSRE WLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKD STKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTAR YWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTG NIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN*" /label="eglS CDS" gene 1656611..1658110 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /label="eglS gene" promotor_-10 complement(1657143..1657162) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1657166) /Source="Nicolas_upshifts" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1657176..1657185) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1658058 /Source="Nicolas_upshifts" /id="D995" /incds=0 /nref=1 /ntot=89 /MaxReadThrough="3.59763" /MaxDrop="3.67571" /score="6.04626297" /energy="-10.7" /TU="NA" /idTUdmin="U1470" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1658178..1658441 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389696.1" /db_xref="EnsemblGenomes-Gn:BSU18140" /db_xref="EnsemblGenomes-Tr:CAB13697" /db_xref="InterPro:IPR020302" /db_xref="SubtiList:BG11829" /db_xref="UniProtKB/Swiss-Prot:Q45069" /translation="MDEILKQYMVLYKKMSNMINGPDYPGKEKDIQHQKDQIEVYEKQ LQQGFSTDYDYDVFADSVIKCAYGDMTLEDLEAVYYGLTTPFF*" /label="ynfE CDS" gene 1658178..1658441 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /label="ynfE gene" downshifts complement(1658700) /Source="Nicolas_upshifts" /id="D996" /incds=0 /nref=4 /ntot=148 /MaxReadThrough="1.78569" /MaxDrop="4.04338" /score="32.2414244" /energy="-12.6" /TU="NA" /idTUdmin="U1472" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1658700..1659968) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /EC_number="3.2.1.136" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17028274, 25355936, 26559526, 28330222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17028274, 25355936, 26559526, 28330222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-xylanase" /protein_id="NP_389697.1" /db_xref="EnsemblGenomes-Gn:BSU18150" /db_xref="EnsemblGenomes-Tr:CAB13698" /db_xref="GOA:Q45070" /db_xref="InterPro:IPR001139" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR033452" /db_xref="PDB:3GTN" /db_xref="PDB:3KL0" /db_xref="PDB:3KL3" /db_xref="PDB:3KL5" /db_xref="SubtiList:BG11830" /db_xref="UniProtKB/Swiss-Prot:Q45070" /translation="MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEK QVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAK SAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNG VNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPIL NDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPE ALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVR IDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSN LQPGTNLTVSGNHFWAHLPAQSVTTFVVNR*" /label="xynC CDS" gene complement(1658700..1659968) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /label="xynC gene" S_feature complement(1659969..1660098) /Source="Nicolas_S_feature" /locus_tag="new_1943983_1944112_c" /HighExp="Lbstat, BC, M0t90, LBGstat, Sw, T2.0H, M40t90, BI, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99419599999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S676" CDS complement(1660099..1661640) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1938968, 17426966, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938968, 17426966, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinoxylan arabinofuranohydrolase" /protein_id="NP_389698.1" /db_xref="EnsemblGenomes-Gn:BSU18160" /db_xref="EnsemblGenomes-Tr:CAB13699" /db_xref="GOA:Q45071" /db_xref="InterPro:IPR005084" /db_xref="InterPro:IPR006584" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR023296" /db_xref="PDB:3C7E" /db_xref="PDB:3C7F" /db_xref="PDB:3C7G" /db_xref="PDB:3C7H" /db_xref="PDB:3C7O" /db_xref="SubtiList:BG11807" /db_xref="UniProtKB/Swiss-Prot:Q45071" /translation="MRKKCSVCLWILVLLLSCLSGKSAYAATSTTIAKHIGNSNPLID HHLGADPVALTYNGRVYIYMSSDDYEYNSNGTIKDNSFANLNRVFVISSADMVNWTDH GAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFANSGGGIGVLTADS PIGPWTDPIGKPLVTPSTPGMSGVVWLFDPAVFVDDDGTGYLYAGGGVPGVSNPTQGQ WANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTHPA DKPPGEIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFNFKNEWYVVYHAQT VSSALFGAGKGYRSPHINKLVHNADGSIQEVAANYAGVTQISNLNPYNRVEAETFAWN GRILTEKSTAPGGPVNNQHVTSIQNGDWIAVGNADFGAGGARSFKANVASTLGGKIEV RLDSADGKLVGTLNVPSTGGAQTWREIETAVSGATGVHKVFFVFTGTGTGNLFNFDYW QFTQR*" /label="xynD CDS" gene complement(1660099..1661640) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /label="xynD gene" S_feature complement(1661641..1661962) /Source="Nicolas_S_feature" /locus_tag="new_1945655_1945976_c" /HighExp="M0t90, LBGstat, T1.30H, T2.30H, BC, M9-stat, T2.0H, T3.0H, T0.30H, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25588499999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S677" promotor_-10 complement(1661952..1661971) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1661963) /Source="Nicolas_upshifts" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1661986..1661989) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1662189..1662196 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1662209..1662228 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1662216 /Source="Nicolas_upshifts" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1662235..1662681 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein possibly involved in arabinogalactan metabolism" /protein_id="NP_389699.1" /db_xref="EnsemblGenomes-Gn:BSU18170" /db_xref="EnsemblGenomes-Tr:CAB13700" /db_xref="GOA:O31821" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG13452" /db_xref="UniProtKB/Swiss-Prot:O31821" /translation="MTATRIFYEGRFVTLKEKIKTLGRFCTVGVGNTLIDFGVFFLLT ACHVSYLPAQICSYTAGIVNSYVWNRNWTFCVKRKADGKEIVRFLMINIAASGITFLL LYLFQNCGCSLLVSKLAATIGGMMMNFIGNRIWVFGDSLKNIQDQE*" /label="yngA CDS" gene 1662235..1662681 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /label="yngA gene" CDS 1662688..1663581 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /EC_number="2.7.7.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8320212, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_389700.1" /db_xref="EnsemblGenomes-Gn:BSU18180" /db_xref="EnsemblGenomes-Tr:CAB13701" /db_xref="GOA:O31822" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13453" /db_xref="UniProtKB/Swiss-Prot:O31822" /translation="MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVE EAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHY IRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGV QSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVL KTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM RSQLLAYLEDVIKRETKEMLR*" /label="yngB CDS" gene 1662688..1663581 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /label="yngB gene" misc_feature 1663198..1663217 /Source="Nicolas_upshift_promotors" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1663206 /Source="Nicolas_upshifts" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="upshifts" CDS 1663654..1664250 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein, phosphatase or phosphate isomerase" /protein_id="NP_389701.1" /db_xref="EnsemblGenomes-Gn:BSU18190" /db_xref="EnsemblGenomes-Tr:CAB13702" /db_xref="GOA:O31823" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13454" /db_xref="UniProtKB/Swiss-Prot:O31823" /translation="MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSE GTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQK YGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQ WDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR*" /label="yngC CDS" gene 1663654..1664250 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /label="yngC gene" downshifts 1664240 /Source="Nicolas_upshifts" /id="D997" /incds=0 /nref=191 /ntot=259 /MaxReadThrough="1.94273" /MaxDrop="5.58345" /score="15.4353025" /energy="-15" /TU="NA" /idTUdmin="U1474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1664299..1665498) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19553197, 22262096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19553197, 22262096; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoribonuclease (nanoRNase)" /protein_id="NP_389702.1" /db_xref="EnsemblGenomes-Gn:BSU18200" /db_xref="EnsemblGenomes-Tr:CAB13703" /db_xref="GOA:O31824" /db_xref="SubtiList:BG13455" /db_xref="UniProtKB/Swiss-Prot:O31824" /translation="MYHLYSHNDLDGVGCGIVAKLAFGKDVEIRYNSVNGLNAQVQYF LEKAKESNRQDALFITDLAVNEENEERLNEYVHAGGKVKLIDHHKTALHLNEHEWGFV QVEYDDGRLTSATSLLYGYLIENGFMKPTNALDQFTELVRQYDTWEWERYDQKQAKRL NDLFFLLSIDEFEAKMIQRLSTHDEFFFDDFEEKLLDLEDEKIERYLRRKKREMVQTF VHEHCVGIVHAESYHSELGNRLGKDNPHLDYIAILSMGSKRVSLRTIHDYIDVSEIAG RYGGGGHAKASGCSITDEVYELFVAEAFRIDPVRPDAFRNIYNLKGSANGSLYENRAQ MRFFLFPLDNEWNIQINGETQDETFAAFEEAEWFIKRNYAASLVRDEVFVAFLAENLK LANQHRK*" /label="nrnB CDS" gene complement(1664299..1665498) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /label="nrnB gene" S_feature complement(1665499..1665570) /Source="Nicolas_S_feature" /locus_tag="new_1949513_1949584_c" /HighExp="S5, S7, S4, S8, S6, ferm, nit, LBGstat, T5.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S678" promotor_-10 complement(1665558..1665569) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1665570) /Source="Nicolas_upshifts" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1665584..1665590) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1665668..1667203) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /EC_number="6.4.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylcrotonoyl-CoA carboxylase subunit (leucinedegradation)" /protein_id="NP_389703.2" /db_xref="EnsemblGenomes-Gn:BSU18210" /db_xref="EnsemblGenomes-Tr:CAB13704" /db_xref="GOA:O31825" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13456" /db_xref="UniProtKB/Swiss-Prot:O31825" /translation="MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLF DDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKI IRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSIS GCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAP FDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSA DKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSV IVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAA FISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPV YPV*" /label="ldeE CDS" gene complement(1665668..1667203) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /label="ldeE gene" downshifts complement(1665680) /Source="Nicolas_upshifts" /id="D998" /incds=0 /nref=18 /ntot=38 /MaxReadThrough="1.74923" /MaxDrop="5.31437" /score="-1.4478995" /energy="-11.8" /TU="NA" /idTUdmin="U1477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1667214..1667996) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /EC_number="4.2.1.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglutaconyl-CoA hydratase (leucine degradation)" /protein_id="NP_389704.1" /db_xref="EnsemblGenomes-Gn:BSU18220" /db_xref="EnsemblGenomes-Tr:CAB13705" /db_xref="GOA:O34893" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG13457" /db_xref="UniProtKB/Swiss-Prot:O34893" /translation="MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIE FNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIA AINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKE FIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGL ETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI*" /label="ldeF CDS" gene complement(1667214..1667996) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /label="ldeF gene" CDS complement(1668017..1668916) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /EC_number="4.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxymethylglutaryl-CoA lyase (leucine degradation)" /protein_id="NP_389705.1" /db_xref="EnsemblGenomes-Gn:BSU18230" /db_xref="EnsemblGenomes-Tr:CAB13706" /db_xref="GOA:O34873" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR013785" /db_xref="PDB:1YDO" /db_xref="SubtiList:BG13458" /db_xref="UniProtKB/Swiss-Prot:O34873" /translation="MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSY IEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFM SASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVI RLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALAN MVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSA AKWIEEKMGKPLPSRNLQVFKSS*" /label="ldeG CDS" gene complement(1668017..1668916) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /label="ldeG gene" CDS complement(1668931..1669152) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type c: carrier" /codon_start=1 /transl_table=11 /product="methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation)" /protein_id="YP_003097733.1" /db_xref="EnsemblGenomes-Gn:BSU18239" /db_xref="EnsemblGenomes-Tr:CAX52627" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR011053" /db_xref="PDB:1Z6H" /db_xref="PDB:1Z7T" /db_xref="PDB:2B8F" /db_xref="PDB:2B8G" /db_xref="UniProtKB/Swiss-Prot:C0H419" /translation="MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADR SGIVKEVKKKEGDFVNEGDVLLELSNSTQ*" /label="lgeHB CDS" gene complement(1668931..1669152) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /label="lgeHB gene" CDS complement(1669167..1670501) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /EC_number="6.4.1.4" /EC_number="6.3.4.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7915138, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase" /protein_id="NP_389706.1" /db_xref="EnsemblGenomes-Gn:BSU18240" /db_xref="EnsemblGenomes-Tr:CAB13707" /db_xref="GOA:O34544" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG13459" /db_xref="UniProtKB/Swiss-Prot:O34544" /translation="MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKA ATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVF IGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQH GHTVHLFERDCSVQRRHQKVIEEAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEF IVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHA IEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKG QTRTEAIEKLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL*" /label="ldeHA CDS" gene complement(1669167..1670501) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /label="ldeHA gene" CDS complement(1670511..1672160) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /EC_number="6.2.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12535077, 15213221, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl-CoA synthetase" /protein_id="NP_389707.1" /db_xref="EnsemblGenomes-Gn:BSU18250" /db_xref="EnsemblGenomes-Tr:CAB13708" /db_xref="GOA:O31826" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13460" /db_xref="UniProtKB/Swiss-Prot:O31826" /translation="MAELIHSTIGRLLEQTADAYPDRDAVVYPDRNIRYTYAQFDSLC RQTAKGLMRMGIGKGDHVAIWASNISEWLAVQFATAKIGAVLVTVNTNYQAHELDYLL KQSDAAALIIMDSYRGTSYPDIVNSLIPELQEAKPGQLKSERYPFLKTLIYIGNKRLS GMYHWDDTEILAKTVTDAELEERMNSLDKDNVINMQYTSGTTGFPKGVMLTHFNVINN AANIAECMALTSQDRMCIPVPFFHCFGCVLGVLACVSVGAAMIPVQEFDPVTVLKTVE KEKCTVLHGVPTMFIAELHHPDFDAYDLSTLRTGIMAGSPCPSEVMKAVIERMGMKDI TIAYGQTEASPVITQTRANDSFIRRVETTGRALPHTEVKIVEPGTCQEVQRGMQGELC TRGYHVMKGYYKDKDATRKAINHDGWLFTGDLAVMDEDGYCRITGRLKDMLIRGGENI YPREIEEFLYQHPAVLDVQVVGVPDAKFGEEAAAWIKLKDGKSVSPDELKAYCKGKIA RHKIPRYVIFTDDYPMTASGKIQKYKLREKTIEMFNLSSSQ*" /label="ldeI CDS" gene complement(1670511..1672160) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /label="ldeI gene" promotor_no_box 1670560..1670660 /Source="Nicolas_upshift_promotors" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1670620 /Source="Nicolas_upshifts" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1672204..1673346) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /EC_number="1.3.8.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8655474, 17085570, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isovaleryl-CoA dehydrogenase (leucine degradation)" /protein_id="NP_389708.1" /db_xref="EnsemblGenomes-Gn:BSU18260" /db_xref="EnsemblGenomes-Tr:CAB13709" /db_xref="GOA:O34421" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG13461" /db_xref="UniProtKB/Swiss-Prot:O34421" /translation="MNFELTKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKK MGELGLMGIPFPEEYGGSGGDTISYALAVEEVGKACGSTGLSYAAAVSLGASPLYYFG TEEQKQTHLTPLASGTALGSFGLTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNA SYARTVIVTAVTGKNKDGKNIISALIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDV RVPAANLLGDPTKGFKQFLYTLDGGRISIAALAVGIAQAALDASLAYAKERKQFGQPI SSFQAIQFKLADMAMEIDLARQMVLKAAWLKDHNRPFTKEAAYAKLFASEMATRACNQ AIQIHGGSGYMKEYGVERMLRDAKLMEIGEGTSEIQRLVIARQLLK*" /label="ldeJ CDS" gene complement(1672204..1673346) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /label="ldeJ gene" promotor_-10 complement(1673365..1673383) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1673382) /Source="Nicolas_upshifts" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1673399..1673404) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1673437..1673742) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389709.1" /db_xref="EnsemblGenomes-Gn:BSU18270" /db_xref="EnsemblGenomes-Tr:CAB13710" /db_xref="GOA:O34356" /db_xref="InterPro:IPR020509" /db_xref="SubtiList:BG13468" /db_xref="UniProtKB/Swiss-Prot:O34356" /translation="MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIK LGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK* " /label="ynzE CDS" gene complement(1673437..1673742) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /label="ynzE gene" CDS complement(1673732..1673905) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513961.1" /translation="MNMEAVFGHLPLLESEKLVLNKNKIEEKHVQDVFYVFISSLVRC HIIFCAVRRCCVD*" /label="conserved protein of unknown function CDS" gene complement(1673732..1673905) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /label="gene" CDS complement(1674013..1675545) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative exported glycoside hydrolase" /protein_id="NP_389710.1" /db_xref="EnsemblGenomes-Gn:BSU18280" /db_xref="EnsemblGenomes-Tr:CAB13711" /db_xref="InterPro:IPR003790" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG13462" /db_xref="UniProtKB/Swiss-Prot:O35015" /translation="MKVCQKSIVRFLVSLIIGTFVISVPFMANAQSDRELRAVWIASV LNIDWPSKKGLSVKEQKQEYIKLLDDVQKMGMNAVIVQIKPTADAFYPSAYGPWSEYL TGVQGKDPGYDPLAFMIEETHKRNLEFHAWFNPYRITMNHTDLNKLSEDHPARKHPDW VAAYGNQLYYHPGIPEARDFIVKGIEEVVKHYDIDAVHMDDYFYPYKIAGQEFPDQAQ YEQYGKDAFSNIDDWRRDNVNQLVKQINQTIKAAKPYVKFGISPFGVWRNAADDPTGS NTKAGVRNYDDLYADTRHWIQEGDIDYIAPQIYWSIGFNAAAYDVLADWWSNEVKNRP VHLYIGQAAYKINNNFDPPWSDPEEYVRQITLNRQLELVKGSMHFSLKDLNKNPLGIK DSLSTDLYSKPALVPQMPWLDNTAPKKPKLTKVTEDKNGNLLQIKDHPSNQKTKETAY YAIYRAEGKKQRTLLATQRKTHEQQTFLDNTADPNKKYTYYVTSADRLHNESKASKRT TK*" /label="yngK CDS" gene complement(1674013..1675545) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /label="yngK gene" downshifts complement(1674024) /Source="Nicolas_upshifts" /id="D999" /incds=0 /nref=7 /ntot=27 /MaxReadThrough="2.27934" /MaxDrop="4.41371" /score="9.43133612" /energy="-8" /TU="NA" /idTUdmin="U1478" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1675580..1675599) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1675580) /Source="Nicolas_upshifts" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1675612..1675621) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1675681..1676073) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28163698; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389711.1" /db_xref="EnsemblGenomes-Gn:BSU18290" /db_xref="EnsemblGenomes-Tr:CAB13712" /db_xref="GOA:O34506" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13463" /db_xref="UniProtKB/Swiss-Prot:O34506" /translation="MDRLSFLTFIMLILASYRLTHLIVFDKITEFIRKPFMKKKRIVD QNGHVDEKSVPASNFGYMLNCYWCAGVWCAILIGLGYLFLPRIAIPLIFILAIAGAQA ILETAVGVGVKLIDVLKSLQTMMNDKKS*" /label="yngL CDS" gene complement(1675681..1676073) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /label="yngL gene" downshifts complement(1675712) /Source="Nicolas_upshifts" /id="D1000" /incds=0 /nref=2 /ntot=18 /MaxReadThrough="0.581539999999999" /MaxDrop="2.96298" /score="5.25915686" /energy="-11.4" /TU="NA" /idTUdmin="U1479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1676101..1676112) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1676108) /Source="Nicolas_upshifts" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1676126..1676132) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1676180,1676187) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs10" N_region 1676181..1676186 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs10" S_feature complement(<1676187..1676292) /Source="Nicolas_S_feature" /locus_tag="new_1997958_1998066_c" /HighExp="T1.30H, T1.0H, T0.30H, S1, M0t90, T2.30H, LPhT, C90, LoTm, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S679" promotor_-10 complement(1676277..1676296) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1676292) /Source="Nicolas_upshifts" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1676310..1676317) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1676566..1678041) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /EC_number="3.4.16.4" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733705, 9864321, 11160090, 14731276, 17582436, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 9864321, 11160090, 14731276, 17582436, 19758330; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase" /protein_id="NP_389717.1" /db_xref="EnsemblGenomes-Gn:BSU18350" /db_xref="EnsemblGenomes-Tr:CAB13718" /db_xref="GOA:P39844" /db_xref="InterPro:IPR000667" /db_xref="InterPro:IPR012338" /db_xref="PDB:1W5D" /db_xref="PDB:2J9P" /db_xref="SubtiList:BG10969" /db_xref="UniProtKB/Swiss-Prot:P39844" /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKIL ADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFT TEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTW HDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVS PKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAG YALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAE VLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQ LLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSL SGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ*" /label="dacC CDS" gene complement(1676566..1678041) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /label="dacC gene" downshifts complement(1676578) /Source="Nicolas_upshifts" /id="D1003" /incds=0 /nref=126 /ntot=224 /MaxReadThrough="1.56173" /MaxDrop="5.81468" /score="20.5621533" /energy="-10.2" /TU="NA" /idTUdmin="U1484" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(1678075..1679052) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /EC_number="5.1.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9733705, 12753898, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 12753898, 19758330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldose 1-epimerase" /protein_id="NP_389718.1" /db_xref="EnsemblGenomes-Gn:BSU18360" /db_xref="EnsemblGenomes-Tr:CAB13719" /db_xref="GOA:P39840" /db_xref="InterPro:IPR008183" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR014718" /db_xref="PDB:3MWX" /db_xref="PDB:4BZE" /db_xref="PDB:4BZF" /db_xref="PDB:4BZG" /db_xref="PDB:4BZH" /db_xref="SubtiList:BG10253" /db_xref="UniProtKB/Swiss-Prot:P39840" /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTN VQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHG FLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHA TVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEAL HEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGK QGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ*" /label="galM CDS" gene complement(1678075..1679052) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /label="galM gene" promotor_-10 complement(1679081..1679099) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1679093) /Source="Nicolas_upshifts" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1679111..1679119) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1679186..1680577) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven efflux transporter" /protein_id="NP_389719.2" /db_xref="EnsemblGenomes-Gn:BSU18370" /db_xref="EnsemblGenomes-Tr:CAB13720" /db_xref="GOA:O34474" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13548" /db_xref="UniProtKB/Swiss-Prot:O34474" /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGM MAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGT TLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYT TFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFL VLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFV NHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWL NYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMR ASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQ FVWKKKQITRLIQ*" /label="yoeA CDS" gene complement(1679186..1680577) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /label="yoeA gene" downshifts complement(1679200) /Source="Nicolas_upshifts" /id="D1004" /incds=0 /nref=74 /ntot=213 /MaxReadThrough="2.12119" /MaxDrop="5.14152" /score="31.8413544" /energy="-12.3" /TU="NA" /idTUdmin="U1486" /TUdmin=2 /isTUend="TRUE" /label="downshifts" downshifts 1679346 /Source="Nicolas_upshifts" /id="D1005" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="1.76262" /MaxDrop="3.63403" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1485" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" promotor_-35 1680367..1680373 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-35" promotor_-10 1680387..1680405 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-10" S_feature 1680398..1680731 /Source="Nicolas_S_feature" /locus_tag="new_2002172_2002505" /HighExp="M9-stat, Etha, Gly, S8, Sw, S7, B60, S6, Salt, C30" /AntisenseName="yoeA" /AntisenseCor="9.0133358617756607E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S680" upshifts 1680398 /Source="Nicolas_upshifts" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="upshifts" S_feature complement(1680578..1680682) /Source="Nicolas_S_feature" /locus_tag="new_2002352_2002456_c" /HighExp="S8, LBGstat, Etha, Cold, S7, T-1.40H, S2, C90, nit, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.456" /TUlongSig="NA" /TUlongPSig="NA" /label="S681" promotor_no_box complement(1680642..1680742) /Source="Nicolas_upshift_promotors" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1680682) /Source="Nicolas_upshifts" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1680704..1680709 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1680725..1680743 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1680733 /Source="Nicolas_upshifts" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1680791..1680798 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1680811..1680830 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1680814 /Source="Nicolas_upshifts" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" CDS 1680863..1681408 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17483219, 17581128, 18761694, 22720735, 23091053" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483219, 17581128, 18761694, 22720735, 23091053; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of DL-endopeptidases involved in cell-separation" /protein_id="NP_389720.2" /db_xref="EnsemblGenomes-Gn:BSU18380" /db_xref="EnsemblGenomes-Tr:CAB13721" /db_xref="InterPro:IPR031841" /db_xref="PDB:2RSX" /db_xref="SubtiList:BG13549" /db_xref="UniProtKB/Swiss-Prot:O34841" /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSARE HFWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEK GFKDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAK RKVTFVKENKKWKVNQFDAVI*" /label="iseA CDS" gene 1680863..1681408 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /label="iseA gene" downshifts 1681392 /Source="Nicolas_upshifts" /id="D1006" /incds=0 /nref=164 /ntot=264 /MaxReadThrough="4.38689" /MaxDrop="8.27665" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA complement(1681502..1681574) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg1 tRNA" gene complement(1681502..1681574) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /label="trnSL-Arg1 gene" downshifts complement(1681600) /Source="Nicolas_upshifts" /id="D1007" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="1.99821" /MaxDrop="3.03097" /score="3.94141467" /energy="-15.1" /TU="NA" /idTUdmin="U1489" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1681627..1682172) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacteriophage integrase" /protein_id="NP_389721.2" /db_xref="EnsemblGenomes-Gn:BSU18390" /db_xref="EnsemblGenomes-Tr:CAB13722" /db_xref="GOA:O35009" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG13550" /db_xref="UniProtKB/Swiss-Prot:O35009" /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDI LPLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRK PISRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSIT MRYIGIDEDTTRAAYKVFGGL*" /label="yoeC CDS" gene complement(1681627..1682172) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /label="yoeC gene" promotor_-10 complement(1682212..1682231) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1682226) /Source="Nicolas_upshifts" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1682245..1682252) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1682488..1682718) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16880568; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excisionase" /protein_id="NP_389722.1" /db_xref="EnsemblGenomes-Gn:BSU18400" /db_xref="EnsemblGenomes-Tr:CAB13723" /db_xref="GOA:O34555" /db_xref="InterPro:IPR010093" /db_xref="SubtiList:BG13551" /db_xref="UniProtKB/Swiss-Prot:O34555" /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQF KTHLEQLENYKALVQEILNEPIPEDIDVKDED*" /label="yoeD CDS" gene complement(1682488..1682718) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /label="yoeD gene" downshifts complement(1682502) /Source="Nicolas_upshifts" /id="D1008" /incds=0 /nref=193 /ntot=248 /MaxReadThrough="0.81591" /MaxDrop="5.75977" /score="19.8797745" /energy="-8.6" /TU="NA" /idTUdmin="U1490" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1682744..1682763) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1682756) /Source="Nicolas_upshifts" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1682775..1682781) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1682810..1682829) /Source="Nicolas_upshift_promotors" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1682820) /Source="Nicolas_upshifts" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1682833..1682840 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1682854..1682873 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1682858 /Source="Nicolas_upshifts" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="upshifts" CDS 1682903..1684666 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /EC_number="2.3.2.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8763966, 23335395, 24279353, 26370226, 28120195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763966, 23335395, 24279353, 26370226, 28120195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound gamma-glutamyltranspeptidase" /protein_id="NP_389723.1" /db_xref="EnsemblGenomes-Gn:BSU18410" /db_xref="EnsemblGenomes-Tr:CAB13724" /db_xref="GOA:P54422" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="PDB:2V36" /db_xref="PDB:3A75" /db_xref="PDB:3WHQ" /db_xref="PDB:3WHR" /db_xref="PDB:3WHS" /db_xref="SubtiList:BG11838" /db_xref="UniProtKB/Swiss-Prot:P54422" /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVG KDGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDG KTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDK WGTRSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGD TLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPI WGDYQGYQIATTPPPSSGGIFLLQMLKILDHFNLSQYDVRSWEKYQLLAETMHLSYAD RASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQV EQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIP GGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELK AAVEEPRIYTNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGT FKGVADSSRNGAAIGINLKRK*" /label="ggt CDS" gene 1682903..1684666 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /label="ggt gene" downshifts 1684647 /Source="Nicolas_upshifts" /id="D1009" /incds=0 /nref=24 /ntot=49 /MaxReadThrough="1.41914" /MaxDrop="5.80171" /score="3.23845421" /energy="-10.4" /TU="NA" /idTUdmin="U1492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1684767..1685624) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17526699" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_389724.1" /db_xref="EnsemblGenomes-Gn:BSU18420" /db_xref="EnsemblGenomes-Tr:CAB13725" /db_xref="GOA:O34685" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13552" /db_xref="UniProtKB/Swiss-Prot:O34685" /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLN IRLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETMAV THLPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVS HDELVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAI IKGVSAGMGTALLPKSAVDGSEHRTNVWIHQLPPSYQDLEIVFIYRKDFFITSAFQTF LDEINEMKR*" /label="ftsR CDS" gene complement(1684767..1685624) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /label="ftsR gene" promotor_-10 complement(1685670..1685689) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1685690) /Source="Nicolas_upshifts" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1685703..1685710) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1685752..1686741 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 23873705; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389725.1" /db_xref="EnsemblGenomes-Gn:BSU18430" /db_xref="EnsemblGenomes-Tr:CAB13726" /db_xref="GOA:O35017" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13553" /db_xref="UniProtKB/Swiss-Prot:O35017" /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDL FLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPE ILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEH LLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQ GKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTS MGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME*" /label="yogA CDS" gene 1685752..1686741 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /label="yogA gene" S_feature complement(1685808..1686766) /Source="Nicolas_S_feature" /locus_tag="new_2007582_2008540_c" /HighExp="T-4.40H, T-5.40H, Glu, GM 45, Glucon, GM-0.1, Gly, GM-0.2, UNK1, GM 90" /AntisenseName="yogA" /AntisenseCor="-0.49303153269799599" /AntisenseRegPval="-17.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S682" CDS complement(1686798..1688279) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3011766, 10651638, 11029411, 27223617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3011766, 10651638, 11029411, 27223617; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (small subunit, NADP-dependent)" /protein_id="NP_389726.2" /db_xref="EnsemblGenomes-Gn:BSU18440" /db_xref="EnsemblGenomes-Tr:CAB13727" /db_xref="GOA:O34399" /db_xref="InterPro:IPR006005" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028261" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12594" /db_xref="UniProtKB/Swiss-Prot:O34399" /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGA RCMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFT GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGS GPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGID FVTNTEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKS YLDSNFKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTN DNMWPEQPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVK NEHGKYEFRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQT NIDGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP*" /label="gltB CDS" gene complement(1686798..1688279) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /label="gltB gene" downshifts complement(1686811) /Source="Nicolas_upshifts" /id="D1010" /incds=0 /nref=247 /ntot=279 /MaxReadThrough="3.292" /MaxDrop="7.52772" /score="10.4717228" /energy="-6.5" /TU="U1495" /idTUdmin="U1495" /TUdmin="-570" /isTUend="FALSE" /label="downshifts" CDS complement(1688296..1692858) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (large subunit, NADP-dependent)" /protein_id="NP_389727.2" /db_xref="EnsemblGenomes-Gn:BSU18450" /db_xref="EnsemblGenomes-Tr:CAB13728" /db_xref="GOA:P39812" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="SubtiList:BG10811" /db_xref="UniProtKB/Swiss-Prot:P39812" /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLK MLCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKNINLPEKERYGVGMVFFSQKE DERKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKD NLSFERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEA FVSAFALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFG EDLNKILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRA FYEYHSSLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIE VEQENVLYKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDP ESREEEQFSDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQS LFNYFKQLFAQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSN EQFYALKTIVHPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNE RLTPIPPLLAVSALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLA YATYKQEIDEGRLDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGI SRDVIDRYFSGTASQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEH HAFNPKTIHTLQWACRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVES AESIVKRFKTGAMSFGSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDR RSAIKQIASGRFGVKSHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTP GVGLISPPPHHDIYSIEDLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATAD VIVISGYDGGTGASPKTSIKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGR DVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHI VNYMLFIAEEVREYMAALGFKTFDEMIGRTDVLHASERAKEHWKASQLDLSTLLYQPE GVRTFQSPQNHKIDQSLDITTILPAVQEAIESGKEADISIEINNTNRVAGTITGSEIS KRYGEEGLPEDTIKLHFTGSAGQSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKS SEGFNSASDDNVIIGNVAFYGATSGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEY MTGGSVVVLGDVGKNFAAGMSGGIAYVLTEDVKAFKRKCNLEMILFESLEDEKEIQQI KAMLERHTAYTNSQKAEDLLDQWEDSVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEA IMFAFEANTKPKQNTAASGQKQAVVQ*" /label="gltA CDS" gene complement(1688296..1692858) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /label="gltA gene" promotor_no_box 1691319..1691419 /Source="Nicolas_upshift_promotors" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1691379 /Source="Nicolas_upshifts" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1692859..1692930) /Source="Nicolas_S_feature" /locus_tag="new_2014633_2014704_c" /HighExp="SMM, T-5.40H, HiOs, MG 15, Glu, T-4.40H, MG 150, MG 60, UNK1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S683" promotor_-10 complement(1692910..1692929) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1692927..1692934 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1692930) /Source="Nicolas_upshifts" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1692944..1692951) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1692946 /Source="Nicolas_upshifts" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1692949..1692968 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1693005..1693907 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2548995, 15150225, 17134717, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family) (GltC-glutamate)" /protein_id="NP_389728.2" /db_xref="EnsemblGenomes-Gn:BSU18460" /db_xref="EnsemblGenomes-Tr:CAB13729" /db_xref="GOA:P20668" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10810" /db_xref="UniProtKB/Swiss-Prot:P20668" /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELN VTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLA SQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLV STEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNR ELAPSANDFYEFVIQFFSKLEQYQ*" /label="gltC CDS" gene 1693005..1693907 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /label="gltC gene" downshifts 1693887 /Source="Nicolas_upshifts" /id="D1011" /incds=0 /nref=104 /ntot=241 /MaxReadThrough="2.84467" /MaxDrop="3.98111" /score="22.3639229" /energy="-13.6" /TU="NA" /idTUdmin="U1496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1693959..1695074) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /EC_number="2.7.2.11" /function="16.8: Protect" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:11418582, 15804359, 21784929, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 15804359, 21784929, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389729.1" /db_xref="EnsemblGenomes-Gn:BSU18470" /db_xref="EnsemblGenomes-Tr:CAB13740" /db_xref="GOA:O07509" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG12658" /db_xref="UniProtKB/Swiss-Prot:O07509" /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDA GYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVAS QILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVA GLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMR SKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFN SGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVN YSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN*" /label="proJ CDS" gene complement(1693959..1695074) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /label="proJ gene" CDS complement(1695071..1695964) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21784929, 22139509, 25344233, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21784929, 22139509, 25344233, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase" /protein_id="NP_389730.2" /db_xref="EnsemblGenomes-Gn:BSU18480" /db_xref="EnsemblGenomes-Tr:CAB13741" /db_xref="GOA:P0CI77" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11049" /db_xref="UniProtKB/Swiss-Prot:P0CI77" /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQ NICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRI QPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKK LAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSI GAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAK RSKEISEDIEKTAAPLSGVIK*" /label="proH CDS" gene complement(1695071..1695964) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /label="proH gene" promotor_-10 complement(1695969..1695988) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1695977 /Source="Nicolas_upshifts" /id="D1012" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="1.17009" /MaxDrop="3.27004" /score="-0.988973561" /energy="-13.3" /TU="NA" /idTUdmin="U1496" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" upshifts complement(1695987) /Source="Nicolas_upshifts" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1696002..1696008) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1696017..1696035) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1696035) /Source="Nicolas_upshifts" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1696051..1696056) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1696112..1696480) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11313334, 15657033, 16822523, 17376071, 17521668, 24946150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11313334, 15657033, 16822523, 17376071, 17521668, 24946150; Product type f : factor" /codon_start=1 /transl_table=11 /product="replication terminator protein" /protein_id="NP_389731.1" /db_xref="EnsemblGenomes-Gn:BSU18490" /db_xref="EnsemblGenomes-Tr:CAB13742" /db_xref="GOA:P0CI76" /db_xref="InterPro:IPR003432" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1BM9" /db_xref="PDB:1F4K" /db_xref="PDB:1J0R" /db_xref="PDB:2DPD" /db_xref="PDB:2DPU" /db_xref="PDB:2DQR" /db_xref="PDB:2EFW" /db_xref="SubtiList:BG10738" /db_xref="UniProtKB/Swiss-Prot:P0CI76" /translation="MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSE FKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQ LKVELDRCKKLIEKALSDNF*" /label="rtp CDS" gene complement(1696112..1696480) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /label="rtp gene" promotor_-10 complement(1696515..1696533) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-10" upshifts complement(1696538) /Source="Nicolas_upshifts" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="upshifts" S_feature complement(1696540..1696659) /Source="Nicolas_S_feature" /locus_tag="new_2018314_2018433_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, LBGtran, LoTm, LBGexp, G180, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S684" promotor_-35 complement(1696545..1696553) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-35" promotor_-10 complement(1696651..1696670) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1696659) /Source="Nicolas_upshifts" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1696661..1696757) /Source="Nicolas_S_feature" /locus_tag="new_2018435_2018531_c" /HighExp="Etha, dia15, LBGtran, LoTm, dia5, H2O2, LBGexp, M0t45, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S685" promotor_-35 complement(1696685..1696692) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1696780..1697496) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxido-reductase" /protein_id="NP_389732.1" /db_xref="EnsemblGenomes-Gn:BSU18500" /db_xref="EnsemblGenomes-Tr:CAB13743" /db_xref="GOA:P14802" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11048" /db_xref="UniProtKB/Swiss-Prot:P14802" /translation="MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVE KVAEEVKALGVKAAFAAADVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFLDL SADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAAVTSAYSASKF AVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVA QLKLDPRIFIKTAGLWSTNP*" /label="yoxD CDS" gene complement(1696780..1697496) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /label="yoxD gene" downshifts complement(1696802) /Source="Nicolas_upshifts" /id="D1013" /incds=0 /nref=109 /ntot=217 /MaxReadThrough="4.9568" /MaxDrop="5.08605" /score="27.1231718" /energy="-7.5" /TU="U1501" /idTUdmin="U1500" /TUdmin="-594" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1697534..1697553) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1697543) /Source="Nicolas_upshifts" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1697569..1697572) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1697597..1697603 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1697617..1697635 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1697622 /Source="Nicolas_upshifts" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="upshifts" CDS 1697647..1697952 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16513748, 17598888; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="transition-dependent and sulfur-related metabolism protein" /protein_id="NP_389733.1" /db_xref="EnsemblGenomes-Gn:BSU18510" /db_xref="EnsemblGenomes-Tr:CAB13744" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG11047" /db_xref="UniProtKB/Swiss-Prot:P28670" /translation="MIIVYISLAVLAVSIIFLGVTVIQNKKKIDPALKELSSVTQAMQ KQIEGLKTETELLTQKQKKIQQDVQIKKYTLQQTAAEVKEVPQAVKEVWQAGHFNSR* " /label="yoxC CDS" gene 1697647..1697952 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /label="yoxC gene" downshifts 1697936 /Source="Nicolas_upshifts" /id="D1014" /incds=0 /nref=6 /ntot=88 /MaxReadThrough="5.31272" /MaxDrop="3.8396" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin="-1473" /isTUend="FALSE" /label="downshifts" CDS 1698023..1698793 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 17598888, 19703276" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389734.1" /db_xref="EnsemblGenomes-Gn:BSU18520" /db_xref="EnsemblGenomes-Tr:CAB13745" /db_xref="InterPro:IPR020530" /db_xref="InterPro:IPR036895" /db_xref="SubtiList:BG11046" /db_xref="UniProtKB/Swiss-Prot:P28671" /translation="MIINRSCLKEFAEKVHFLPSSLTKSDLLTDPFRLHQENELGIYY SPHNEFINRDASLVIAGITPGFSQMKTAYETAAESLLQGGTLEQMAVDTKIAAGFSGS MRHNLITMLDLCGLPQAFGIQSAAKLFGELRHMLHTTSVIKYPVFIQQKNYTGYKPAI THSPILSTYAFGHFPAELNHVTGPALLIPLGKAAETVCETLIRQHSLQNLICLNGFPH PSGANGHRLKQFSKNKEQLERQIRSFAALVDFAIEKRK*" /label="yoxB CDS" gene 1698023..1698793 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /label="yoxB gene" promotor_-35 1698775..1698782 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1698794 /Source="Nicolas_upshifts" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1698797..1698816 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1698837..1699370 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 11717291, 17598888; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389735.2" /db_xref="EnsemblGenomes-Gn:BSU18530" /db_xref="EnsemblGenomes-Tr:CAB13746" /db_xref="GOA:O34569" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13472" /db_xref="UniProtKB/Swiss-Prot:O34569" /translation="MFPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESI EQAISMIQTFAALYQEKRGIRWGIERRDTKELIGTIGFHALAQKHRRAEIGYEIIPEH WRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEGVLRQYMYQ NGTPYDTNVYSIVKPRE*" /label="yoaA CDS" gene 1698837..1699370 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /label="yoaA gene" S_feature 1699371..1699456 /Source="Nicolas_S_feature" /locus_tag="new_2021145_2021230" /HighExp="Salt, Sw, B60, LoTm, B36, M9-stat, BC, Lbstat, HiTm, Etha" /AntisenseName="yoaB" /AntisenseCor="-0.17521117067018899" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S686" downshifts 1699413 /Source="Nicolas_upshifts" /id="D1015" /incds=0 /nref=6 /ntot=100 /MaxReadThrough="4.32682" /MaxDrop="3.67936" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1699449..1700693) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12193636, 15849754, 16513748, 16850406, 28546427; Product type t : transporter" /codon_start=1 /transl_table=11 /product="negatively charged metabolite transporter" /protein_id="NP_389736.1" /db_xref="EnsemblGenomes-Gn:BSU18540" /db_xref="EnsemblGenomes-Tr:CAB13747" /db_xref="GOA:O34864" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13473" /db_xref="UniProtKB/Swiss-Prot:O34864" /translation="MLDKIGIPKRLAWGFLGVVLFMMGDGLEQGWLSPFLIENGLTVQ QSASIFSIYGIALAIASWFSGVCLEAFGAKRTMFMGLLFYVIGTAAFIVFGFEQLNLP VMYVTYFVKGLGYPLFAYSFLTWVIYRTPQSKLSTAVGWFWIAYCLGMFVFGAWYSSY AIKAFGYLNTLWSSIFWVCLGAFFALFINKDRFEKKKRKRSETAEELLKGVTILFTNP RVLTGGIIRIINSIGTYGFPVFLPMHMAQHGISTNVWLQIWGTIFLGNIVFNLIFGIV GDKFGWKNTVIWFGGVGCGIFTVLLYYAPVFSGGSLAVVSVIGFIWGGLLAGYVPIGA IVPTVAGKDKGAAMSVLNLAAGLSAFVGPALAWLFIGLVGAQGVVWIFAALYLASAVL TKCIHIPEEKAVKEETSPQYAS*" /label="yoaB CDS" gene complement(1699449..1700693) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /label="yoaB gene" S_feature 1699458..1700197 /Source="Nicolas_S_feature" /locus_tag="new_2021232_2021971" /HighExp="LoTm, Salt, Sw, S6, Etha, M9-stat, LPhT, B60, T2.0H, T2.30H" /AntisenseName="yoaB" /AntisenseCor="-0.18536963552729299" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S687" downshifts complement(1699463) /Source="Nicolas_upshifts" /id="D1016" /incds=0 /nref=32 /ntot=113 /MaxReadThrough="2.59019" /MaxDrop="4.97477" /score="29.0246554" /energy="-12.5" /TU="NA" /idTUdmin="U1504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1700694..1700786) /Source="Nicolas_S_feature" /locus_tag="new_2022468_2022560_c" /HighExp="MG 10, MG 5, BMM, MG t5, MG 15, GM 25, HiTm, UNK1, GM 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S688" CDS complement(1700787..1702250) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10094622, 12193636, 16850406, 18039762, 21749987, 27795321, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxylated metabolite kinase" /protein_id="NP_389737.1" /db_xref="EnsemblGenomes-Gn:BSU18550" /db_xref="EnsemblGenomes-Tr:CAB13748" /db_xref="GOA:O34861" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG13474" /db_xref="UniProtKB/Swiss-Prot:O34861" /translation="MKKQKGYLVFDIGTGNARVAVVSVTGSVLTVEREDIEYSTETLY PDSRYFSPQVLWKQVMNLAKRALSRSCDIDIIGLTSTSQRQGIVLIDQNGNPFLGLPN IDNRGREWEAGIPDWEEIYSSTGRLPTALFSALKLYGLKQRQPSLWEKTASFTSISDW VTYQLSGILTYEPSQATETLLFDVKQNTWSEEMCDIFGFSPSILPPLVRAGTAIGTIA NEYASELGLSINAKVIAGGGDTQLAVKSTGAGLEDIVIVSGTTTPITKITEDHGDTKH KAWLNCHTDQGHWLVETNPGITGLNYQKLKQIFYPNETYEVMEEEISALAKEDHACVA ALGSYLSAEKNALTRGGFLFDAPLSAHLKRAHFVRAALEEIAFSIKWNFDILTEVTPF ERDYVWVCGGGFQSKALTQYIADLLQKKVYVQEGYHQASVVGAAVICNETFQLTEEMS ANVRVIEPKDCQIELALYEEWKQTQRFFSGSESKVLI*" /label="yoaC CDS" gene complement(1700787..1702250) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /label="yoaC gene" CDS complement(1702268..1703302) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10094622, 11390694, 12193636, 17012385, 18039762, 21749987, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-hydroxyacid dehydrogenase" /protein_id="NP_389738.1" /db_xref="EnsemblGenomes-Gn:BSU18560" /db_xref="EnsemblGenomes-Tr:CAB13749" /db_xref="GOA:O34815" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13475" /db_xref="UniProtKB/Swiss-Prot:O34815" /translation="MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQG RAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASK RGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE LTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIV SVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDV FYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTM YNKDALKTGG*" /label="yoaD CDS" gene complement(1702268..1703302) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /label="yoaD gene" S_feature complement(1703314..1703385) /Source="Nicolas_S_feature" /locus_tag="new_2025088_2025159_c" /HighExp="MG t5, MG 5, MG 10, BMM, GM 25, MG 15, Heat, GM 15, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S689" downshifts complement(1703357) /Source="Nicolas_upshifts" /id="D1017" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="7.78218" /MaxDrop="4.81701" /score="26.3160061" /energy="-11.4" /TU="U1504" /idTUdmin="U1507" /TUdmin=2727 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1703386..1703477) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /product="AdoMet riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswF RNA" gene complement(1703386..1703477) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /label="mswF gene" promotor_-10 complement(1703505..1703524) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1703517) /Source="Nicolas_upshifts" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1703539..1703546) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1703559..1703566 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1703580..1703599 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1703584 /Source="Nicolas_upshifts" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="upshifts" CDS 1703626..1705668 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170332, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin cofactor oxido-reductase" /protein_id="NP_389739.2" /db_xref="EnsemblGenomes-Gn:BSU18570" /db_xref="EnsemblGenomes-Tr:CAB13750" /db_xref="GOA:C0SP82" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG13476" /db_xref="UniProtKB/Swiss-Prot:C0SP82" /translation="MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDH PVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQL IDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGI SAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLAD WFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTIT GVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGA IKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVV APEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQL QQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYD SLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFM YVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECEL TAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV*" /label="yoaE CDS" gene 1703626..1705668 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /label="yoaE gene" promotor_-35 1705676..1705685 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1705698..1705713 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1705701 /Source="Nicolas_upshifts" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1705735..1706028 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389740.1" /db_xref="EnsemblGenomes-Gn:BSU18580" /db_xref="EnsemblGenomes-Tr:CAB13751" /db_xref="SubtiList:BG13477" /db_xref="UniProtKB/Swiss-Prot:O31829" /translation="MDVFLGIGIALAGYFIGEGLKQRNQTKGNEQNDIFLIKERDIYF YIGLFLGITTTEAKQLAGDMADLPYIEINGKKYVQKHMLKDWTFTLVEKHQGE*" /label="yoaF CDS" gene 1705735..1706028 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /label="yoaF gene" downshifts 1706008 /Source="Nicolas_upshifts" /id="D1018" /incds=0 /nref=97 /ntot=243 /MaxReadThrough="3.40762" /MaxDrop="4.1662" /score="-6.27063114" /energy="-3.9" /TU="U1506" /idTUdmin="U1505" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1706053..1706400) /Source="Nicolas_S_feature" /locus_tag="new_2027827_2028174_c" /HighExp="T0.30H, S0, T1.0H, aero, Etha, S8, SMMPr, T-0.40H, ferm, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S690" downshifts complement(1706084) /Source="Nicolas_upshifts" /id="D1019" /incds=0 /nref=43 /ntot=202 /MaxReadThrough="2.3171" /MaxDrop="4.25059" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1706401..1706805) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 15849754, 16850406, 20011599, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage-related membrane protein" /protein_id="NP_389741.1" /db_xref="EnsemblGenomes-Gn:BSU18590" /db_xref="EnsemblGenomes-Tr:CAB13752" /db_xref="GOA:O31830" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG13478" /db_xref="UniProtKB/Swiss-Prot:O31830" /translation="MKKIASYYLMTLGLSSLTFGLLLGFYSFVMYGDMIIALFTAAIA LLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSVVAFIAAFLFFVINEPASIAWTL QSYFYYMLSIAAAVIYWLWDSLILYKRTASGV*" /label="yoaG CDS" gene complement(1706401..1706805) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /label="yoaG gene" S_feature complement(1706806..1706901) /Source="Nicolas_S_feature" /locus_tag="new_2028580_2028675_c" /HighExp="T0.30H, T1.0H, T0.0H, T-0.40H, S0, T-1.10H, T-1.40H, SMMPr, Salt, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S691" promotor_-10 complement(1706891..1706906) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1706891..1707010) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513962.1" /translation="MHFFHSRFGQSGEAFSASVLSNKRTSFLKPFISALRIAR*" /label="hypothetical protein CDS" gene complement(1706891..1707010) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /label="gene" upshifts complement(1706901) /Source="Nicolas_upshifts" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1706919..1706928) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1707006..1707012 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1707026..1707037 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1707037..1707245 /Source="Nicolas_S_feature" /locus_tag="new_2028811_2029019" /HighExp="S5, S8, S7, S6, S4, ferm, BT, nit, T5.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99998799999999999" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S692" upshifts 1707037 /Source="Nicolas_upshifts" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1707080..1707202 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513963.1" /db_xref="EnsemblGenomes-Gn:BSU18596" /db_xref="EnsemblGenomes-Tr:CCQ48597" /db_xref="UniProtKB/TrEMBL:L8E9J0" /translation="MSKKGIQNSSIEQIRNDHETETAFKADDPKKHGSDPKRTK*" /label="conserved hypothetical protein CDS" gene 1707080..1707202 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /label="gene" CDS 1707246..1707539 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="YP_054581.1" /db_xref="EnsemblGenomes-Gn:BSU18600" /db_xref="EnsemblGenomes-Tr:CAE01456" /db_xref="InterPro:IPR025100" /db_xref="SubtiList:BG14189" /db_xref="UniProtKB/Swiss-Prot:Q7WY68" /translation="MTQKNGADRPDDYKRFSSLDKEYDFQQSIRSNTETESVNTETQT HNKENKNDTTDVAGKYFEPSDYKGSTQLEKGLAETHEQVSDDYFEGTIDQNLD*" /label="yozQ CDS" gene 1707246..1707539 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /label="yozQ gene" S_feature 1707540..1707633 /Source="Nicolas_S_feature" /locus_tag="new_2029314_2029407" /HighExp="S5, S8, S6, S7, S4, BT, ferm, nit, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S693" downshifts 1707590 /Source="Nicolas_upshifts" /id="D1020" /incds=0 /nref=14 /ntot=74 /MaxReadThrough="3.32407" /MaxDrop="3.87581" /score="-6.27063114" /energy="-3.9" /TU="U1508" /idTUdmin="U1506" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1707655..1709340) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting chemotaxis protein" /protein_id="NP_389742.2" /db_xref="EnsemblGenomes-Gn:BSU18610" /db_xref="EnsemblGenomes-Tr:CAB13753" /db_xref="GOA:C0SP89" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR007891" /db_xref="SubtiList:BG13479" /db_xref="UniProtKB/Swiss-Prot:C0SP89" /translation="MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKME FQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQ SNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRL DQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEI AHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASA EESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSS MRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTN LLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNN IKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVH TLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY*" /label="yoaH CDS" gene complement(1707655..1709340) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /label="yoaH gene" downshifts complement(1707667) /Source="Nicolas_upshifts" /id="D1021" /incds=0 /nref=68 /ntot=193 /MaxReadThrough="2.22411" /MaxDrop="4.20676" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1509" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(1709341..1709428) /Source="Nicolas_S_feature" /locus_tag="new_2031115_2031202_c" /HighExp="Cold, C30, LBGstat, GM 90, GM 15, GM 45, GM 25, GM 60, GM 10, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115923" /TUshortSig="SigD" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S694" promotor_-10 complement(1709420..1709438) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1709428) /Source="Nicolas_upshifts" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1709452..1709459) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1709597..1709606 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1709616 /Source="Nicolas_upshifts" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1709619..1709638 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1709665..1711116 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /EC_number="1.14.14.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 4-hydroxyphenylacetate-3-hydroxylase" /protein_id="NP_389743.2" /db_xref="EnsemblGenomes-Gn:BSU18620" /db_xref="EnsemblGenomes-Tr:CAB13754" /db_xref="GOA:C0SPC0" /db_xref="InterPro:IPR004925" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR012687" /db_xref="InterPro:IPR024674" /db_xref="InterPro:IPR024719" /db_xref="InterPro:IPR036250" /db_xref="SubtiList:BG13480" /db_xref="UniProtKB/Swiss-Prot:C0SPC0" /translation="MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTK SSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMM GRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRS QSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYA FSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNV EAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEII VGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGM VTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFF GDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH*" /label="yoaI CDS" gene 1709665..1711116 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /label="yoaI gene" downshifts 1711092 /Source="Nicolas_upshifts" /id="D1022" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="2.84304" /MaxDrop="2.93575" /score="2.7297367" /energy="-12" /TU="U1510" /idTUdmin="U1510" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1711153..1711851) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 18971341, 26751268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 18971341, 26751268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular endoglucanase precursor (expansin)" /protein_id="NP_389744.1" /db_xref="EnsemblGenomes-Gn:BSU18630" /db_xref="EnsemblGenomes-Tr:CAB13755" /db_xref="GOA:O34918" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036749" /db_xref="InterPro:IPR036908" /db_xref="PDB:2BH0" /db_xref="PDB:3D30" /db_xref="PDB:4FER" /db_xref="PDB:4FFT" /db_xref="PDB:4FG2" /db_xref="PDB:4FG4" /db_xref="SubtiList:BG13481" /db_xref="UniProtKB/Swiss-Prot:O34918" /translation="MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSG GAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGAR GALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKY PVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGT SKAYTVPGHVQFPE*" /label="exlX CDS" gene complement(1711153..1711851) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /label="exlX gene" downshifts complement(1711168) /Source="Nicolas_upshifts" /id="D1023" /incds=0 /nref=6 /ntot=95 /MaxReadThrough="0.66874" /MaxDrop="3.60414" /score="1.1918692" /energy="-7.7" /TU="NA" /idTUdmin="U1511" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1711886..1711905) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1711905) /Source="Nicolas_upshifts" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1711907..1712120) /Source="Nicolas_S_feature" /locus_tag="new_2033681_2033894_c" /HighExp="G135, H2O2, G150, G180, LBGstat, dia15, LBGtran, Paraq, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S695" promotor_-35 complement(1711919..1711926) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1712121..1712798) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_389745.1" /db_xref="EnsemblGenomes-Gn:BSU18640" /db_xref="EnsemblGenomes-Tr:CAB13756" /db_xref="GOA:O34343" /db_xref="InterPro:IPR010699" /db_xref="SubtiList:BG13482" /db_xref="UniProtKB/Swiss-Prot:O34343" /translation="MTAAAYRNTLLSLLCLTAGIVDVIGYLSLGHVFTANMTGNIVLL GLAIGKSIQVTVFNSLTALIGFICGVIIATLMVGKAENTLWPSAVTKALALEAFILFV FACLSFYRAFVPVHILIILMSISMGIQTTAAKKLGIAGISSTVLTGTLASLLEDISGR LFFKKQKKTFLRDTVLRALAIILYCVGAIIVALAEPDFYHFIIWVPIVLIFGIMMTAK LKLSGEK*" /label="yoaK CDS" gene complement(1712121..1712798) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /label="yoaK gene" S_feature complement(1712799..1715288) /Source="Nicolas_S_feature" /locus_tag="new_2034573_2037062_c" /HighExp="LBGstat, G135, H2O2, G180, LBGtran, G150, dia15, Paraq, S0, Diami" /AntisenseName="pelB" /AntisenseCor="0.19898265589133701" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S696" CDS 1712971..1714008 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /EC_number="4.2.2.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1731776, 2018526, 2185758, 7764549, 22695924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-pectin lyase" /protein_id="NP_389746.1" /db_xref="EnsemblGenomes-Gn:BSU18650" /db_xref="EnsemblGenomes-Tr:CAB13757" /db_xref="GOA:O34819" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12643" /db_xref="UniProtKB/Swiss-Prot:O34819" /translation="MKRLCLWFTVFSLFLVLLPGKALGAVDFPNTSTNGLLGFAGNAK NEKGISKTGTTGGKNGQIVYIQSVNDLKTHLGGSTPKILVLQNDLSASAKTTVTIGSN KTLVGSYAKKTLKNIYLTTSSAFGNVIFQNLTFEHSPQINGNNDIQLYLDSGMNYWID HVTFSGHSYNASGSDLDKLVYIGKSADYITISNSKFANHKYGLILGYPDDSQHQYDGY PHMTIANNYFENLYVRGPGLMRYGYFHVKNNYSNNFNQAITIATKAKIYSEYNYFGKG SEKGGILDDKGTGYFKDIGSYPSLNKQTSPLTSWNPGSNYSYRVQTPEYTKEFVTKYA GSQSTTLVFGY*" /label="pelB CDS" gene 1712971..1714008 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /label="pelB gene" promotor_-35 1714205..1714211 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1714226..1714237 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1714238 /Source="Nicolas_upshifts" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1714265..1714948 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23945014, 26070154; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative SOS response associated protein; defective prophage 6" /protein_id="NP_389747.1" /db_xref="EnsemblGenomes-Gn:BSU18660" /db_xref="EnsemblGenomes-Tr:CAB13758" /db_xref="GOA:O34906" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13483" /db_xref="UniProtKB/Swiss-Prot:O34906" /translation="MCGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAI INDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETITEKPAFRRPLVSKRCIIPAD SFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIITTEPNEFMK DIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSA ELLDAENHM*" /label="yoaM CDS" gene 1714265..1714948 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /label="yoaM gene" CDS complement(1715289..1715594) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative permease, phage-related; defective prophage 6" /protein_id="YP_003097734.1" /db_xref="EnsemblGenomes-Gn:BSU18669" /db_xref="EnsemblGenomes-Tr:CAX52628" /db_xref="GOA:C0H420" /db_xref="UniProtKB/Swiss-Prot:C0H420" /translation="MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLI SLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSITLDKQKKEDLHVR* " /label="yozS CDS" gene complement(1715289..1715594) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /label="yozS gene" S_feature complement(1715595..1715696) /Source="Nicolas_S_feature" /locus_tag="new_2037369_2037470_c" /HighExp="HiTm, LBGstat, LBGtran, T1.30H, T1.0H, T0.30H, M9-stat, Lbstat, M0t90, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S697" promotor_-10 complement(1715675..1715694) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1715696) /Source="Nicolas_upshifts" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1715709..1715716) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1715724..1715826) /Source="Nicolas_S_feature" /locus_tag="new_2037498_2037600_c" /HighExp="S8, S6, S7, S5, BT, G/S, Pyr, B36, nit, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S698" downshifts complement(1715766) /Source="Nicolas_upshifts" /id="D1024" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="1.67639" /MaxDrop="3.95763" /score="-5.39979801" /energy="-8.3" /TU="NA" /idTUdmin="U1514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1715827..1717005) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11546787, 14697267, 14973022, 15628860, 25526893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11546787, 14697267, 14973022, 15628860, 25526893; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase (Mn2+-dependent); spore constituent" /protein_id="NP_389748.1" /db_xref="EnsemblGenomes-Gn:BSU18670" /db_xref="EnsemblGenomes-Tr:CAB13759" /db_xref="GOA:O34767" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="SubtiList:BG13484" /db_xref="UniProtKB/Swiss-Prot:O34767" /translation="MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIF VPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRE LHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFL LVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSV ASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGA MRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGT ETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT *" /label="oxdD CDS" gene complement(1715827..1717005) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /label="oxdD gene" promotor_-10 complement(1717031..1717050) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1717050) /Source="Nicolas_upshifts" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1717064..1717073) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1717128..1717616) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389749.1" /db_xref="EnsemblGenomes-Gn:BSU18680" /db_xref="EnsemblGenomes-Tr:CAB13760" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG13485" /db_xref="UniProtKB/Swiss-Prot:O34985" /translation="MRKKNNIKKWLLIIAGFLIICIITLFVMVSGNKVKYEGSGKSGL WMSNLEKSDKTSIGPNYFLNLYWQGSKKEEKWTVVERITLYVDGEKYQDDNVDEYDLS EYTGDEMPGGGRMEDHISTFDYMPEDEVIGHDVLVKVEWRTGQKKQTEAIKLHKKPWY KK*" /label="yoaO CDS" gene complement(1717128..1717616) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /label="yoaO gene" downshifts complement(1717153) /Source="Nicolas_upshifts" /id="D1025" /incds=0 /nref=32 /ntot=201 /MaxReadThrough="0.50319" /MaxDrop="3.84714" /score="18.561323" /energy="-9.2" /TU="NA" /idTUdmin="U1514" /TUdmin="-1387" /isTUend="FALSE" /label="downshifts" CDS complement(1717641..1717796) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513964.1" /translation="MKQKMHLRAVIRFNLVFRKHFNLSQKFRQSSVRSLALSYFLFGN ILIVFSY*" /label="hypothetical protein CDS" gene complement(1717641..1717796) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /label="gene" CDS complement(1717836..1718591) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389750.1" /db_xref="EnsemblGenomes-Gn:BSU18690" /db_xref="EnsemblGenomes-Tr:CAB13761" /db_xref="GOA:O34983" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR025685" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13486" /db_xref="UniProtKB/Swiss-Prot:O34983" /translation="MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGL VFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIAD AKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAF KSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSP AIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA*" /label="yoaP CDS" gene complement(1717836..1718591) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /label="yoaP gene" promotor_-35 1718844..1718849 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1718865..1718883 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1718880 /Source="Nicolas_upshifts" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="upshifts" CDS 1718899..1719255 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389751.1" /db_xref="EnsemblGenomes-Gn:BSU18700" /db_xref="EnsemblGenomes-Tr:CAB13762" /db_xref="SubtiList:BG13487" /db_xref="UniProtKB/Swiss-Prot:O31831" /translation="MVEKCYSCLICGYKGLIQNPLYKGEYQKTFDICPCCGFEFGYSE DHDVRLGFIVTPDHLIEAAFQLYRKQWLESGMVIAHPEDIPEELKNGNCLKFEVLLKQ LKKLNLDIENFEISGF*" /label="yoaQ CDS" gene 1718899..1719255 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /label="yoaQ gene" CDS complement(1719214..1719453) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (putative phage origin); putative defective prophage 6" /protein_id="YP_003097735.1" /db_xref="EnsemblGenomes-Gn:BSU18709" /db_xref="EnsemblGenomes-Tr:CAX52629" /db_xref="UniProtKB/Swiss-Prot:C0H421" /translation="MTVINDYREEPEEAFWILYPMGVKCLSMITKSLLNTNRDFVTDC AFQLNILLIMTVKPKQVQPVSSLKTANFKIFYVKI*" /label="yozT CDS" gene complement(1719214..1719453) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /label="yozT gene" S_feature 1719256..1719692 /Source="Nicolas_S_feature" /locus_tag="new_2041030_2041466" /HighExp="S8, S7, S4, S5, S6, S3, T5.0H, LoTm, BT, T4.0H" /AntisenseName="yozT" /AntisenseCor="0.93420248567111996" /AntisenseRegPval="-120.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S699" S_feature complement(1719454..1719555) /Source="Nicolas_S_feature" /locus_tag="new_2041228_2041329_c" /HighExp="S8, S7, S6, S5, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S700" CDS complement(1719556..1720053) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389752.2" /db_xref="EnsemblGenomes-Gn:BSU18710" /db_xref="EnsemblGenomes-Tr:CAB13763" /db_xref="SubtiList:BG13753" /db_xref="UniProtKB/Swiss-Prot:O31832" /translation="MKRVLFSVIVFTAVGFTFCQSKAHALTFTVLPITQKTDQWSVKV SEAKNVKEFTRPHKGEYQVYSLEVKNIGEKAATVDVQLYRNDPNSITRFSLFGCPDEN CVKPKEDSKMLAESLNDGSPLKFNHFMLADKASELEVVIIWTQKGQEGRNLKQTFKFT EDGVN*" /label="yozF CDS" gene complement(1719556..1720053) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /label="yozF gene" S_feature complement(1720054..1720153) /Source="Nicolas_S_feature" /locus_tag="new_2041828_2041927_c" /HighExp="S8, S7, S5, S6, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S701" CDS complement(1720154..1721065) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8631706; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor for cell wall maintenance or synthesis" /protein_id="NP_389753.1" /db_xref="EnsemblGenomes-Gn:BSU18720" /db_xref="EnsemblGenomes-Tr:CAB13764" /db_xref="InterPro:IPR007391" /db_xref="SubtiList:BG13488" /db_xref="UniProtKB/Swiss-Prot:O34611" /translation="MIQILITGLFLLAQPSEPQDSLTVTQQGRTIATVNREDFTMPLP GTPMVDYEKYSKFIKQLDQKVYREPINAVLNDHGSIVPGRVGYKLYQQAFMEKFYAYF YGQGPSKIEVPEMNIYPKVDSELLAHISTQQLGQYVTYFNSSNKSRSHNISLSAKAID NHVVFPNETFSFNQVVGMRTRNKGYKSAPIIVKGELSEGVGGGICQVSSTLFNAVDRA GLQIVQRYSHTRSVPYVPPGRDATVSWGGPDFRFQNQYNQPILIRAKRYGGSMIITLY SSDVINSRLRKIPKAPSRIPKEINAEQ*" /label="yoaR CDS" gene complement(1720154..1721065) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /label="yoaR gene" promotor_-10 complement(1721087..1721098) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1721089) /Source="Nicolas_upshifts" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1721113..1721119) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1721349..1721356 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1721365 /Source="Nicolas_upshifts" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1721371..1721390 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1721412..1721894 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19493340; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin / antitoxin system" /protein_id="NP_389754.1" /db_xref="EnsemblGenomes-Gn:BSU18730" /db_xref="EnsemblGenomes-Tr:CAB13765" /db_xref="GOA:O31833" /db_xref="InterPro:IPR021354" /db_xref="SubtiList:BG13489" /db_xref="UniProtKB/Swiss-Prot:O31833" /translation="MNRMSTIFLKIALVLIGIPILALCIFLVPKVANYSAELFPNIAY IKYLVFIYLYVTAIPFYFALYQAFKLLSYIDKNKAFSGLSVRALKNIKYCAVTISIFY AAGMPVFYLMAEIDDAPGIIVIGLVIIFASMVIAVFAAVLQKLLKEAIDIKSENDLTV *" /label="yoaS CDS" gene 1721412..1721894 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /label="yoaS gene" CDS 1721904..1722158 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19493340; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator" /protein_id="NP_389755.1" /db_xref="EnsemblGenomes-Gn:BSU18740" /db_xref="EnsemblGenomes-Tr:CAB13766" /db_xref="GOA:O31834" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG13754" /db_xref="UniProtKB/Swiss-Prot:O31834" /translation="MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIR LSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK*" /label="yozG CDS" gene 1721904..1722158 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /label="yozG gene" S_feature 1722159..1722263 /Source="Nicolas_S_feature" /locus_tag="new_2043933_2044037" /HighExp="LoTm, B60, Sw, G135, G180, B36, LBGstat, Cold, LBGtran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S702" CDS 1722264..1723058 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389756.1" /db_xref="EnsemblGenomes-Gn:BSU18750" /db_xref="EnsemblGenomes-Tr:CAB13767" /db_xref="GOA:O34535" /db_xref="InterPro:IPR008535" /db_xref="SubtiList:BG13490" /db_xref="UniProtKB/Swiss-Prot:O34535" /translation="MRAIKQIVHFGWEQALSCLFPAVIFASLAITQIIPLPFLPRYDW LLIICVLMQLWMVRSGLETRDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKIFG VPLYSGFMYASVASYLCQAWRRLKVELVKWPSFFAVVPLAAAIYLNFFTHHFSIDIRW WLSGLVIIVFWQTWVTYEVNGARYRMPLALSFILIGFFIWIAENIATFFGAWKYPNQI DTWSLVHLGKVSSWLLLVIVSFLIVASLKQVKEQSPTKAEMDESFS*" /label="yoaT CDS" gene 1722264..1723058 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /label="yoaT gene" S_feature 1723059..1724069 /Source="Nicolas_S_feature" /locus_tag="new_2044833_2045843" /HighExp="LoTm, Cold, Sw, H2O2, B60, GM 10, S8, dia15, T2.30H, MG 60" /AntisenseName="yoaU" /AntisenseCor="-2.6976304882719598E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S703" CDS complement(1723182..1724054) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_389757.1" /db_xref="EnsemblGenomes-Gn:BSU18760" /db_xref="EnsemblGenomes-Tr:CAB13768" /db_xref="GOA:O34701" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13491" /db_xref="UniProtKB/Swiss-Prot:O34701" /translation="MVMNMNHLHIFVKVGEKLNITEAAKELFISQPAVSKAIKNLESS LQLKLLIRDKHHGLMLTDIGKEILLLARQMKGIESKIYQVANRENKLLNGKVKIGSFP AVSTNIMPQAIAAFRSNYPLIRIELIEGTSDQIKGWVEDRTVDIGIAASPFEPFENQL LCNDYMVAVIPPQRDELKLEKHVDLETYQDDLIFCKGGHEIAMSNAFSQYNIELKENL TVQNAETLINMVKNNLGIGIISNFTLSSVPHQLIKKDIFPRVTRDIGVIAHSFEEITP AAHEFVKVLKAVVI*" /label="yoaU CDS" gene complement(1723182..1724054) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /label="yoaU gene" CDS 1724155..1725033 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10844694, 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative modified amino acid or TCA compound efflux permease" /protein_id="NP_389758.1" /db_xref="EnsemblGenomes-Gn:BSU18770" /db_xref="EnsemblGenomes-Tr:CAB13769" /db_xref="GOA:O34416" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG13492" /db_xref="UniProtKB/Swiss-Prot:O34416" /translation="MVKVMLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAV PLFLILFIQRKKLSIQKEHLKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMP IFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALS WGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFN GLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQLHEQITINIILGALLI CCGIFMNTFTFSRRKV*" /label="yoaV CDS" gene 1724155..1725033 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /label="yoaV gene" S_feature complement(1725146..1725205) /Source="Nicolas_S_feature" /locus_tag="new_2046920_2046979_c" /HighExp="BC, T4.0H, M9-stat, S5, T5.0H, S4, S3, T3.0H, T3.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.167154" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S704" downshifts complement(1725181) /Source="Nicolas_upshifts" /id="D1026" /incds=0 /nref=55 /ntot=175 /MaxReadThrough="1.78313" /MaxDrop="5.17096" /score="15.465237" /energy="-12.3" /TU="NA" /idTUdmin="U1518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1725206..1725637) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm forming exported protein" /protein_id="NP_389759.1" /db_xref="EnsemblGenomes-Gn:BSU18780" /db_xref="EnsemblGenomes-Tr:CAB13770" /db_xref="SubtiList:BG13493" /db_xref="UniProtKB/Swiss-Prot:O34541" /translation="MKKMLMLAFTFLLALTIHVGEASAVIVKDEEKVSFTMTENEKWF MKSDDLNSNHWTSHFGYRFTIFDTEGCTINARIMRMTLSGYEITVSEKNFSGDHFDFS ATDRVETMPYKTHYLILTKDPDCGDVKVKGLYGFQFDQPEW*" /label="yoaW CDS" gene complement(1725206..1725637) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /label="yoaW gene" promotor_-10 complement(1725657..1725676) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1725665) /Source="Nicolas_upshifts" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1725667..1725900) /Source="Nicolas_S_feature" /locus_tag="new_2047441_2047674_c" /HighExp="S4, S3, S5, S7, S8, S6, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S705" promotor_-35 complement(1725690..1725696) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1725901..1725919) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1725901..1726533) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16181642; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor of the oxidative stress response" /protein_id="NP_389760.1" /db_xref="EnsemblGenomes-Gn:BSU18790" /db_xref="EnsemblGenomes-Tr:CAB13771" /db_xref="GOA:O34947" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13494" /db_xref="UniProtKB/Swiss-Prot:O34947" /translation="MQTRKVYLYVFHTMSDWEYGYLIAELNSGRYFKQDAASLKVVTV GVNKEMITTLGGLSIKPDISLDECTLGSQDLIILPGGNTWGEDIHQPILKKVGDALKL GTTIAAICGATLGLANEGYLNSRKHTSNDLDYMNMVCPNYKGETFYEKGPAVSDENLV TASGIAPLEFAVEVLKKLDVFAPDTLRSWYKLNKTQKPEYFFELMNTINR*" /label="yoaZ CDS" gene complement(1725901..1726533) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /label="yoaZ gene" upshifts complement(1725907) /Source="Nicolas_upshifts" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1725935..1725940) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1726671..1726678 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1726693..1726712 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1726697 /Source="Nicolas_upshifts" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="upshifts" CDS 1726759..1727679 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /EC_number="3.5.2.6" /function="16.5: Explore" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7789815, 15187182, 16944130, 22211522, 25112476, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-lactamase precursor (putative hydrolase)" /protein_id="NP_389761.1" /db_xref="EnsemblGenomes-Gn:BSU18800" /db_xref="EnsemblGenomes-Tr:CAB13772" /db_xref="GOA:P39824" /db_xref="InterPro:IPR000871" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023650" /db_xref="SubtiList:BG11016" /db_xref="UniProtKB/Swiss-Prot:P39824" /translation="MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNM ASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKK NSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTT DKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVV AILSNRFTKDANYDNALIAEAAKVVLNDLK*" /label="penP CDS" gene 1726759..1727679 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /label="penP gene" promotor_-10 complement(1727190..1727209) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1727205) /Source="Nicolas_upshifts" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1727224..1727231) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1727680..1728337 /Source="Nicolas_S_feature" /locus_tag="new_2049454_2050111" /HighExp="HiOs, S8, GM 25, GM 15, GM-0.1, C30, S2, S1, BC, GM 45" /AntisenseName="yobA" /AntisenseCor="8.9918765131424994E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S706" CDS complement(1728176..1728538) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389762.1" /db_xref="EnsemblGenomes-Gn:BSU18810" /db_xref="EnsemblGenomes-Tr:CAB13773" /db_xref="InterPro:IPR021598" /db_xref="PDB:2JQO" /db_xref="PDB:4QY7" /db_xref="SubtiList:BG13495" /db_xref="UniProtKB/Swiss-Prot:O31835" /translation="MPKIGVSLIVLIMLIIFLAGCNKNEQNGDETKMQSLVGYVVLKD NERAILITDTKAPGKEDYNLSEGQLMNKFKNNIVIVGLSEIDNTDDLKRGEKIKVWFH TRKESNPPSATIQKYELL*" /label="yobA CDS" gene complement(1728176..1728538) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /label="yobA gene" CDS complement(1728599..1728811) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage protein" /db_xref="PSEUDO:CAX52630.1" /translation="MEVAIVNDSKDKYIYAGIQKEAAFNNIFESAKMSKRIISRATTC KYLRKNKKKVEELENEYAAVMNCKKK*" /label="yozU CDS" gene complement(1728599..1728811) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /pseudo /label="yozU gene" promotor_-35 1728850..1728857 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1728872..1728891 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1728875 /Source="Nicolas_upshifts" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="upshifts" CDS 1728915..1729178 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="NP_389763.1" /db_xref="EnsemblGenomes-Gn:BSU18820" /db_xref="EnsemblGenomes-Tr:CAB13774" /db_xref="SubtiList:BG13496" /db_xref="UniProtKB/Swiss-Prot:O31836" /translation="MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTI YRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV*" /label="yobB CDS" gene 1728915..1729178 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /label="yobB gene" downshifts 1729156 /Source="Nicolas_upshifts" /id="D1027" /incds=0 /nref=23 /ntot=100 /MaxReadThrough="0.60454" /MaxDrop="4.81085" /score="19.5390064" /energy="-8.7" /TU="NA" /idTUdmin="U1522" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1729555..1732155) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /EC_number="2.7.9.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PEP-dependent enzyme" /protein_id="NP_389764.1" /db_xref="EnsemblGenomes-Gn:BSU18830" /db_xref="EnsemblGenomes-Tr:CAB13775" /db_xref="GOA:O34309" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG12657" /db_xref="UniProtKB/Swiss-Prot:O34309" /translation="MSSLVLGLHEIEKTQLSLVGGKGLHLGELSKIQGIQVPEGFCVT TVGYQKAIEQNETLQVLLDQLTMLKVEDRDQIGNISRKIRQIIMEVDIPSDVVKAVAQ YLSQFGEEHAYAVRSSATAEDLPHASFAGQQDTYLNITGVDAILQHISKCWASLFTDR AVIYRMQNGFDHSQVYLSVIVQRMVFPQASGILFTADPITSNRKVLSIDAGFGLGEAL VSGLVSADCFKVQDGQIIDKRIATKKMAIYGRKEGGTETQQIDSDQQKAQTLTDEQIL QLARIGRQIEAHFGQPQDIEWCLARDTFYIVQSRPITTLFPIPEASDQENHVYISVGH QQMMTDPIKPLGLSFFLLTTVAPMRKAGGRLFVDVTHHLASPDSREVFLKGMGQHDQL LKDALMTIIKRRDFIKSIPNDKTAPNPSRGNADMPAQVENDPTIVSDLIESSQTSIEE LKQNIQTKSGSDLFRFILEDIQELKKILFNPKSSVLIRTAMNASLWINEKMNEWLGEK NAADTLSQSVPHNITSEMGLALLDVADVIRPYPEVIDYLQHVKDDNFLDELAKFDGGS KTRDAIYDYLSKYGMRCTGEIDITRTRWSEKPTTLVPMILNNIKNFEPNVGHRKFEQG RQEALKKEQELLDRLKQLPDGEQKAKETKRAIDIIRNFSGFREYPKYGMVNRYFVYKQ ALLKEAEQLIEAGVIHEKEDIYYLTFEELHEVVRTHKLDYQIISTRKDEYTLYEKLSP PRVITSDGEIVTGEYKRENLPAGAIVGLPVSSGVIEGRARVILNMEDADLEDGDILVT SFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENAAKLIKDGQRIRV HGTEGYIEIF*" /label="yppS CDS" gene complement(1729555..1732155) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /label="yppS gene" S_feature complement(1732156..1732265) /Source="Nicolas_S_feature" /locus_tag="new_2053930_2054039_c" /HighExp="dia15, BC, S6, SMMPr, H2O2, S5, T-5.40H, S4, HPh, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S707" promotor_-35 1732181..1732188 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1732203..1732222 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1732211..1732838 /Source="Nicolas_S_feature" /locus_tag="new_2053985_2054612" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, S1, T2.30H, Heat, S2, T-5.40H, C30" /AntisenseName="xynA" /AntisenseCor="-0.30871986344497798" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S708" upshifts 1732211 /Source="Nicolas_upshifts" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1732255..1732274) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1732265) /Source="Nicolas_upshifts" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1732289..1732295) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1732311..1732770) /Source="Nicolas_S_feature" /locus_tag="new_2054085_2054544_c" /HighExp="S0, Lbstat, HiTm, dia0, ferm, Lbexp, T1.0H, M0t45, LBGtran, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S709" downshifts complement(1732353) /Source="Nicolas_upshifts" /id="D1028" /incds=0 /nref=87 /ntot=200 /MaxReadThrough="1.89557" /MaxDrop="5.26144" /score="1.97345986" /energy="-10.4" /TU="NA" /idTUdmin="U1525" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1732815) /Source="Nicolas_upshifts" /id="D1029" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="5.28207" /MaxDrop="3.16026" /score="1.97345986" /energy="-10.4" /TU="U1525" /idTUdmin="U1525" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(1732825..1733466) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /EC_number="3.2.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7704256, 8628241, 16517552, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704256, 8628241, 16517552, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-1,4-beta-xylanase" /protein_id="NP_389765.1" /db_xref="EnsemblGenomes-Gn:BSU18840" /db_xref="EnsemblGenomes-Tr:CAB13776" /db_xref="GOA:P18429" /db_xref="InterPro:IPR001137" /db_xref="InterPro:IPR013319" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018208" /db_xref="InterPro:IPR033119" /db_xref="InterPro:IPR033123" /db_xref="PDB:1AXK" /db_xref="PDB:1XXN" /db_xref="PDB:2B42" /db_xref="PDB:2B45" /db_xref="PDB:2B46" /db_xref="PDB:2DCY" /db_xref="PDB:2DCZ" /db_xref="PDB:2QZ3" /db_xref="PDB:2Z79" /db_xref="PDB:3EXU" /db_xref="PDB:3HD8" /db_xref="PDB:5K9Y" /db_xref="SubtiList:BG10808" /db_xref="UniProtKB/Swiss-Prot:P18429" /translation="MFKFKKNFLVGLSAALMSISLFSATASAASTDYWQNWTDGGGIV NAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINYNAGVWAPNGNGYLTLYGWTRS PLIEYYVVDSWGTYRPTGTYKGTVKSDGGTYDIYTTTRYNAPSIDGDRTTFTQYWSVR QSKRPTGSNATITFSNHVNAWKSHGMNLGSNWAYQVMATEGYQSSGSSNVTVW*" /label="xynA CDS" gene complement(1732825..1733466) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /label="xynA gene" S_feature complement(1733467..1733584) /Source="Nicolas_S_feature" /locus_tag="new_2055241_2055358_c" /HighExp="S0, HiTm, T1.0H, Gly, Lbstat, SMMPr, Lbtran, LBGstat, SMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S710" promotor_-10 complement(1733561..1733580) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1733584) /Source="Nicolas_upshifts" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1733594..1733596) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1733672,1733679) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs05" N_region 1733673..1733678 /note="SacI site (GAGCTC)" /modified_by="User" /label="IIG_Bs05" misc_RNA <1733679..1733763 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /product="small untranslated regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 19542274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 19542274; Product type n: RNA" /label="bsrF RNA" S_feature <1733679..1733756 /Source="Nicolas_S_feature" /locus_tag="new_2079086_2079196" /HighExp="LoTm, S7, HPh, LPhT, S8, BT, S6, G/S, S0, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.896, 1" /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S728" S_feature complement(<1733679..1733743) /Source="Nicolas_S_feature" /locus_tag="new_2078548_2079183_c" /HighExp="MG 150, S8, MG 120, S7, MG 90, GM-0.1, Glu, Fru, GM-0.2, GM 5" /AntisenseName="yobO" /AntisenseCor="0.134597835896198" /AntisenseRegPval="-1.6" /CDS_PredictionProba="0.40121099999999998" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S726" gene <1733679..1733763 /gene="bsrF" /old_locus_tag="BSU_misc_RNA_75" /locus_tag="PG10_pseudo_BSU_misc_RNA_75" /modified_by="User" /label="PG10_pseudo_BSU_misc_RNA_75" downshifts 1733741 /Source="Nicolas_upshifts" /id="D1044" /incds=0 /nref=65 /ntot=254 /MaxReadThrough="1.60135" /MaxDrop="9.06442" /score="30.7999406" /energy="-13.9" /TU="NA" /idTUdmin="U1545" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1733774..1734106) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /function="16.1: Circulate" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10658654, 10816431, 13129613, 15856219, 17372352, 28724440; Product type f : factor" /codon_start=1 /transl_table=11 /product="molecular chaperone for secreting proteins" /protein_id="NP_389785.1" /db_xref="EnsemblGenomes-Gn:BSU19040" /db_xref="EnsemblGenomes-Tr:CAB13796" /db_xref="GOA:P37584" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR008231" /db_xref="InterPro:IPR012340" /db_xref="PDB:2NZH" /db_xref="PDB:2NZO" /db_xref="SubtiList:BG10809" /db_xref="UniProtKB/Swiss-Prot:P37584" /translation="MAVIDDFEKLDIRTGTIVKAEEFPEARVPAIKLVIDFGTEIGIK QSSAQITKRYKPEGLINKQVIAVVNFPPRRIAGFKSEVLVLGGIPGQGDVVLLQPDQP VPNGTKIG*" /label="csaA CDS" gene complement(1733774..1734106) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /label="csaA gene" downshifts complement(1733788) /Source="Nicolas_upshifts" /id="D1045" /incds=0 /nref=28 /ntot=228 /MaxReadThrough="4.42209" /MaxDrop="5.706" /score="-8.98970984" /energy="-13.9" /TU="U1547" /idTUdmin="U1550" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1734171..1734896) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478, 27038276; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_389786.1" /db_xref="EnsemblGenomes-Gn:BSU19050" /db_xref="EnsemblGenomes-Tr:CAB13797" /db_xref="GOA:O34901" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG13508" /db_xref="UniProtKB/Swiss-Prot:O34901" /translation="MLMDSLQEIICEKRTYTRLYHSHKHAYSQFLFPLEGSIDLETEG RQVKLNPDHFLYIPPQCEHRFRSIGRNECLVLDVPLHAMKIDEYRAGSGIEAALDPFW SSIRYLLTEEAKAGTANSLHMLVQYIKEKLQSHSYASIAYIHSHLFERLTIKKLAEIE HYHPAYYSSWFKKQTGKSPQNYIADLRLEEAKRMLMERNETLTVVSEALGFQNLSSFT RWFTKSTGMPPRLYRNTLYSDKK*" /label="yobQ CDS" gene complement(1734171..1734896) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /label="yobQ gene" CDS complement(1734911..1735654) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389787.1" /db_xref="EnsemblGenomes-Gn:BSU19060" /db_xref="EnsemblGenomes-Tr:CAB13798" /db_xref="GOA:O34376" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13509" /db_xref="UniProtKB/Swiss-Prot:O34376" /translation="MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTS ADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCR SIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKM YDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQ VMKENLAAVSLYGKIGFSPISEHHYRIKR*" /label="yobR CDS" gene complement(1734911..1735654) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /label="yobR gene" promotor_-10 complement(1735682..1735701) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1735701) /Source="Nicolas_upshifts" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1735715..1735721) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1735732..1736307) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389788.1" /db_xref="EnsemblGenomes-Gn:BSU19070" /db_xref="EnsemblGenomes-Tr:CAB13799" /db_xref="GOA:O34892" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG13510" /db_xref="UniProtKB/Swiss-Prot:O34892" /translation="MSPRIGLTQKMIVDAAAEIADQEGVNGVSLAALSKKMNVRPPSL YNHINGLQAIRAELAVRGLTKLFDQMADSVTERKGDSAMLSLAHAYVDFAIENPGYYE AALLKVHDKRTEIVSDQIVCLVTKLLIENGYASEKTAIHATRGLRSLLHGFTVLIAKE AFEREEDILESLSFSIRTFLSGLLINNKNIM*" /label="yobS CDS" gene complement(1735732..1736307) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /label="yobS gene" CDS complement(1736313..1737014) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_389789.1" /db_xref="EnsemblGenomes-Gn:BSU19080" /db_xref="EnsemblGenomes-Tr:CAB13800" /db_xref="GOA:O34910" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13511" /db_xref="UniProtKB/Swiss-Prot:O34910" /translation="MRITQYQTVWQLTFFPALFPVNCYLVEEENEVTLIDAALPGSYK GIIQAVNQLGKPLQHILLTHAHGDHVGSLDTLAQTFPHAKVMISERDSFLLQGDTSLR QDEPQTPIKGGIPKHIQTKPHQLLTGGETIGSLLAIPTPGHTPGSMSFLDTRNGTLIA GDAFQLRGGIAVSGQIKWAFPFPAFATWNKEEAIKSAQLLADKAPSCLAVGHGKFLRS PSERMRQAIQKAKKG*" /label="yobT CDS" gene complement(1736313..1737014) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /label="yobT gene" promotor_-10 complement(1737044..1737063) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1737044) /Source="Nicolas_upshifts" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1737048..1737063) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1737078..1737085) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1737078..1737085) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1737088) /Source="Nicolas_upshifts" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1737091..1737573) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative effector of transcriptional regulator" /protein_id="NP_389790.1" /db_xref="EnsemblGenomes-Gn:BSU19090" /db_xref="EnsemblGenomes-Tr:CAB13801" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG13512" /db_xref="UniProtKB/Swiss-Prot:O34637" /translation="MGFSHITHLDLKRFAGLSQRTSNALEMTEERRIPALWDQLWKQD MSALLSQAEKDKSIIALYSNYEQETNGFYTFSVGTFQEYDDILPGPYENIDLPASAYA VFTSRIGPIEEIVLETWKEIWTWDKRHLRTFTGDFEMYDQNAAVPQRAQVNIYVAIKK *" /label="yobU CDS" gene complement(1737091..1737573) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /label="yobU gene" misc_feature complement(1737612..1737629) /Source="Nicolas_upshift_promotors" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1737616) /Source="Nicolas_upshifts" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1737627..1738568) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389791.1" /db_xref="EnsemblGenomes-Gn:BSU19100" /db_xref="EnsemblGenomes-Tr:CAB13802" /db_xref="GOA:O34920" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026881" /db_xref="InterPro:IPR028349" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13513" /db_xref="UniProtKB/Swiss-Prot:O34920" /translation="MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINR AGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQK IKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSAS GETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLD TLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQW LIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET*" /label="yobV CDS" gene complement(1737627..1738568) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /label="yobV gene" downshifts complement(1737660) /Source="Nicolas_upshifts" /id="D1046" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="0.95712" /MaxDrop="3.62763" /score="-3.71616684" /energy="-9" /TU="NA" /idTUdmin="U1548" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1738598..1738617) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1738606) /Source="Nicolas_upshifts" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1738631..1738635) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1738639..1738648 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1738661..1738680 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1738669 /Source="Nicolas_upshifts" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="upshifts" S_feature 1738684..1738748 /Source="Nicolas_S_feature" /locus_tag="new_2084124_2084188" /HighExp="BT, S7, B36, S8, S6, Pyr, G/S, B60, Glucon, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S729" promotor_-35 1738720..1738725 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1738741..1738759 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1738750 /Source="Nicolas_upshifts" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="upshifts" CDS 1738774..1739319 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8990290, 11717295, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 11717295, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="mother cell-specific membrane sporulation protein" /protein_id="NP_389792.1" /db_xref="EnsemblGenomes-Gn:BSU19110" /db_xref="EnsemblGenomes-Tr:CAB13803" /db_xref="GOA:P94497" /db_xref="InterPro:IPR014743" /db_xref="SubtiList:BG12269" /db_xref="UniProtKB/Swiss-Prot:P94497" /translation="MHLTLQSVYPAIIIIFFLYKKIKRSIGYQPLKPRWLFTRIILFS LFAFGLSIFSAIHPFLYGYLILGILGGWLLVFFAKKNISFEKRRGKIYFRTHIWVEVI LLTLFLSRFLYRVTELYLTSPDLNRLGSYSQSIGTDPLTIGVCFLIAVYYIGFSSFII KLSRNELEQHEYNKEKDILAR*" /label="yobW CDS" gene 1738774..1739319 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /label="yobW gene" downshifts 1739278 /Source="Nicolas_upshifts" /id="D1047" /incds=0 /nref=20 /ntot=63 /MaxReadThrough="3.56215" /MaxDrop="4.5413" /score="-4.21976438" /energy="-17.7" /TU="U1552,U1553" /idTUdmin="U1552" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS complement(1739346..1739669) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15948947, 16406068, 16430705, 19170879, 19995076, 25213752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16406068, 16430705, 19170879, 19995076, 25213752; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressor favouring Zn2+)" /protein_id="NP_389793.1" /db_xref="EnsemblGenomes-Gn:BSU19120" /db_xref="EnsemblGenomes-Tr:CAB13804" /db_xref="GOA:O31844" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13748" /db_xref="UniProtKB/Swiss-Prot:O31844" /translation="MTEFRETEQSAADLDEETLFLVAQTFKALSDPTRIRILHLLSQG EHAVNGIAEKLNLLQSTVSHQLRFLKNLRLVKSRREGTSIYYSPEDEHVLDVLQQMIH HTQHD*" /label="czrA CDS" gene complement(1739346..1739669) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /label="czrA gene" downshifts complement(1739353) /Source="Nicolas_upshifts" /id="D1048" /incds=0 /nref=73 /ntot=252 /MaxReadThrough="1.89304" /MaxDrop="4.873" /score="17.3750937" /energy="-18.6" /TU="NA" /idTUdmin="U1554" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1739690..1739709) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1739701) /Source="Nicolas_upshifts" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1739722..1739729) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1739790..1739796 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1739807 /Source="Nicolas_upshifts" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1739811..1739830 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1739863..1740540 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative murein fragments glycosidase" /protein_id="NP_389794.1" /db_xref="EnsemblGenomes-Gn:BSU19130" /db_xref="EnsemblGenomes-Tr:CAB13805" /db_xref="GOA:O34636" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13514" /db_xref="UniProtKB/Swiss-Prot:O34636" /translation="MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDT KTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRN EITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEEL AKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLET MESKAHE*" /label="yocA CDS" gene 1739863..1740540 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /label="yocA gene" downshifts 1740532 /Source="Nicolas_upshifts" /id="D1049" /incds=0 /nref=207 /ntot=268 /MaxReadThrough="3.9729" /MaxDrop="8.52704" /score="-4.21976438" /energy="-17.7" /TU="U1555" /idTUdmin="U1555" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1740630..1741166) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19222757, 24214949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389795.1" /db_xref="EnsemblGenomes-Gn:BSU19140" /db_xref="EnsemblGenomes-Tr:CAB13806" /db_xref="GOA:O31845" /db_xref="InterPro:IPR007352" /db_xref="InterPro:IPR013833" /db_xref="SubtiList:BG13749" /db_xref="UniProtKB/Swiss-Prot:O31845" /translation="MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIH ILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAE NTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLW LYVSLTGVIVYLMISPYY*" /label="yozB CDS" gene complement(1740630..1741166) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /label="yozB gene" downshifts complement(1740653) /Source="Nicolas_upshifts" /id="D1050" /incds=0 /nref=175 /ntot=250 /MaxReadThrough="4.33842" /MaxDrop="7.96098" /score="14.7470642" /energy="-7.7" /TU="U1556" /idTUdmin="U1557" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1741193..1741212) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1741213) /Source="Nicolas_upshifts" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1741226..1741233) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1741303..1742085) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389796.1" /db_xref="EnsemblGenomes-Gn:BSU19150" /db_xref="EnsemblGenomes-Tr:CAB13807" /db_xref="SubtiList:BG13515" /db_xref="UniProtKB/Swiss-Prot:O34516" /translation="MAIDSLINKLQYVQLEPPDKILSLYLNTDMRDPEQQGGEWKIAL KSGFSRLKEYLAASDPEEEKCLDGIRAKMNQYLNAMGKDMPRSLVFFVSDSGIWEPIK LQVPVDTRFYWEETAVLDQLKGLRQTYPSTAFILTQQHEVKIIETVLGKIEAVERYEY DMINESWKNSHSAVDKAPPFEENRMREHVTENQSRLYKRLAASLDQKAAAKRWERMVI AGDKETADILDQHMNKPIHSKIQKNLLNENEHKVIEHLIKEA*" /label="yocB CDS" gene complement(1741303..1742085) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /label="yocB gene" downshifts complement(1741312) /Source="Nicolas_upshifts" /id="D1051" /incds=0 /nref=3 /ntot=38 /MaxReadThrough="5.37496" /MaxDrop="4.00348" /score="14.7470642" /energy="-7.7" /TU="U1557" /idTUdmin="U1557" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1742107..1742125) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1742126) /Source="Nicolas_upshifts" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1742139..1742145) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1742182..1742189 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1742204..1742223 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1742208 /Source="Nicolas_upshifts" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1742256..1742753 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389797.1" /db_xref="EnsemblGenomes-Gn:BSU19160" /db_xref="EnsemblGenomes-Tr:CAB13808" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13516" /db_xref="UniProtKB/Swiss-Prot:O35042" /translation="MFTVKEKNRQELEEELNDLEFQIYRMQENMKDLSKDAKVLGIDQ SKHDEWMIVSSIDDGQTCKIMLTDCKTAYRGKGCFSLVASYKDDAIHIGDIKGPPNHG FGSICMKYLKDIARDHNIPKVTGDIAKRDWNHVDRLIHFYEKHHFKVCIDHDTQSGSI KWVDL*" /label="yocC CDS" gene 1742256..1742753 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /label="yocC gene" promotor_-35 1742760..1742763 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1742779..1742798 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1742781 /Source="Nicolas_upshifts" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1742817..1743794 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /EC_number="3.4.17.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22516613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance)" /protein_id="NP_389798.1" /db_xref="EnsemblGenomes-Gn:BSU19170" /db_xref="EnsemblGenomes-Tr:CAB13809" /db_xref="GOA:O35046" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13517" /db_xref="UniProtKB/Swiss-Prot:O35046" /translation="MYASKLKKGDEIRIVSPATSMSILSNEAKIQAKTALERLGYRVT IAEHANECNEFDSSSIESRVHDLHAAFFDPGVKAILTTLGGFNSNQLLRYLDYEKIKR HPKILCGYSDITALCNAIYQKTGLVTYSGPHFSTFAMKKGLDYTEEYFLSCCASDDPF EIHPSSEWSDDRWFLDQENRRFYPNNGPVVIQEGYAEGTLIGGNLCTLNLLQGTEYFP ETEHTILLIEDDYMSDIHMFDRDLQSLIHLPAFSHVKAILIGRFQKASNVSIDLVKAM IETKKELSGIPIIANINAGHTSPIATFPIGGTCRIEAISGTSRIWIDKH*" /label="yocD CDS" gene 1742817..1743794 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /label="yocD gene" downshifts 1743766 /Source="Nicolas_upshifts" /id="D1052" /incds=0 /nref=131 /ntot=256 /MaxReadThrough="3.77491" /MaxDrop="4.2254" /score="1.66373432" /energy="-9.5" /TU="U1558,U1559" /idTUdmin="U1558" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 1743891..1743898 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1743913..1743932 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1743920 /Source="Nicolas_upshifts" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1743956..1745014 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /EC_number="1.14.19.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid desaturase" /protein_id="NP_389799.1" /db_xref="EnsemblGenomes-Gn:BSU19180" /db_xref="EnsemblGenomes-Tr:CAB13810" /db_xref="GOA:O34653" /db_xref="InterPro:IPR005804" /db_xref="SubtiList:BG13518" /db_xref="UniProtKB/Swiss-Prot:O34653" /translation="MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWF LAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTL FPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFI LGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFL ISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHV HHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHI PVSLPPDSPEKQKLRKNA*" /label="desE CDS" gene 1743956..1745014 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /label="desE gene" S_feature 1745015..1745084 /Source="Nicolas_S_feature" /locus_tag="new_2090455_2090524" /HighExp="Cold, S8, LoTm, Sw, Paraq, BC, S7, S0, Oxctl, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.859" /TUlongSig="SigA, SigA" /TUlongPSig="0.984, 1" /label="S730" promotor_-35 1745068..1745074 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1745086..1745105 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1745086 /Source="Nicolas_upshifts" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1745134..1746246 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component thermosensor histidine kinase [DesR-DesK]" /protein_id="NP_389800.1" /db_xref="EnsemblGenomes-Gn:BSU19190" /db_xref="EnsemblGenomes-Tr:CAB13811" /db_xref="GOA:O34757" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="PDB:3EHF" /db_xref="PDB:3EHG" /db_xref="PDB:3EHH" /db_xref="PDB:3EHJ" /db_xref="PDB:3GIE" /db_xref="PDB:3GIF" /db_xref="PDB:3GIG" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUM" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13519" /db_xref="UniProtKB/Swiss-Prot:O34757" /translation="MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGII LTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERV PFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAAR ELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENIS LLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKG HGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK*" /label="desK CDS" gene 1745134..1746246 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /label="desK gene" CDS 1746265..1746864 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [DesK]" /protein_id="NP_389801.1" /db_xref="EnsemblGenomes-Gn:BSU19200" /db_xref="EnsemblGenomes-Tr:CAB13812" /db_xref="GOA:O34723" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:4LDZ" /db_xref="PDB:4LE0" /db_xref="PDB:4LE1" /db_xref="PDB:4LE2" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13520" /db_xref="UniProtKB/Swiss-Prot:O34723" /translation="MISIFIAEDQQMLLGALGSLLNLEDDMEVVGKGTTGQDAVDFVK KRQPDVCIMDIEMPGKTGLEAAEELKDTGCKIIILTTFARPGYFQRAIKAGVKGYLLK DSPSEELANAIRSVMNGKRIYAPELMEDLYSEANPLTDREKEVLELVADGKNTKEIAQ ELSIKSGTVRNYISMILEKLEVKNRIEAITRSKEKGWFK*" /label="desR CDS" gene 1746265..1746864 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /label="desR gene" downshifts 1746802 /Source="Nicolas_upshifts" /id="D1053" /incds=1 /nref=1 /ntot=41 /MaxReadThrough="4.44811" /MaxDrop="2.78724" /score="23.648858" /energy="-15.4" /TU="U1560" /idTUdmin="U1560" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1746846 /Source="Nicolas_upshifts" /id="D1054" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.88273" /MaxDrop="3.38398" /score="23.648858" /energy="-15.4" /TU="NA" /idTUdmin="U1560" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1746886..1747384) /Source="Nicolas_S_feature" /locus_tag="new_2092326_2092824_c" /HighExp="S4, LoTm, S6, S3, S5, S8, S7, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.230296" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S731" downshifts complement(1746922) /Source="Nicolas_upshifts" /id="D1055" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.62146" /MaxDrop="5.61121" /score="23.7393309" /energy="-12.4" /TU="NA" /idTUdmin="U1563" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1747356..1747365 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1747368..1747386) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1747377..1747571 /Source="Nicolas_S_feature" /locus_tag="new_2092817_2093011" /HighExp="S6, S8, S7, BT, B36, Pyr, G/S, C30, S5, B60" /AntisenseName="yocH" /AntisenseCor="0.113870403460631" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S732" upshifts 1747377 /Source="Nicolas_upshifts" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1747378..1747397 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1747384) /Source="Nicolas_upshifts" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1747403..1747408) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1747459..1748322) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /EC_number="3.2.1.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:17307850, 20070526, 20487291, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17307850, 20070526, 20487291, 26102633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported cell wall lytic enzyme" /protein_id="NP_389802.1" /db_xref="EnsemblGenomes-Gn:BSU19210" /db_xref="EnsemblGenomes-Tr:CAB13813" /db_xref="GOA:O34669" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG13521" /db_xref="UniProtKB/Swiss-Prot:O34669" /translation="MKKTIMSFVAVAALSTTAFGAHASAKEITVQKGDTLWGISQKNG VNLKDLKEWNKLTSDKIIAGEKLTISSEETTTTGQYTIKAGDTLSKIAQKFGTTVNNL KVWNNLSSDMIYAGSTLSVKGQATAANTATENAQTNAPQAAPKQEAVQKEQPKQEAVQ QQPKQETKAEAETSVNTEEKAVQSNTNNQEASKELTVTATAYTANDGGISGVTATGID LNKNPNAKVIAVDPNVIPLGSKVYVEGYGEATAADTGGAIKGNKIDVFVPSKSDASNW GVKTVSVKVLN*" /label="walL CDS" gene complement(1747459..1748322) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /label="walL gene" downshifts complement(1747472) /Source="Nicolas_upshifts" /id="D1056" /incds=0 /nref=227 /ntot=262 /MaxReadThrough="2.55593" /MaxDrop="7.59881" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 1747528 /Source="Nicolas_upshifts" /id="D1057" /incds=1 /nref=8 /ntot=28 /MaxReadThrough="6.14664" /MaxDrop="3.95582" /score="23.648858" /energy="-15.4" /TU="U1562" /idTUdmin="U1560" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1747560) /Source="Nicolas_upshifts" /id="D1058" /incds=1 /nref=10 /ntot=161 /MaxReadThrough="7.34609" /MaxDrop="3.8459" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" S_feature 1747573..1748340 /Source="Nicolas_S_feature" /locus_tag="new_2093013_2093780" /HighExp="BT, S8, S6, Gly, S7, C30, G135, G/S, Fru, Pyr" /AntisenseName="yocH" /AntisenseCor="-0.12155468325348801" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S733" promotor_-35 1748318..1748322 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1748331..1748345 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1748342 /Source="Nicolas_upshifts" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1748361..1748380) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1748374) /Source="Nicolas_upshifts" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1748376..1748569) /Source="Nicolas_S_feature" /locus_tag="new_2093816_2094009_c" /HighExp="LoTm, HiOs, S8, C30, S2, G135, G180, T5.0H, S7, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S734" promotor_-35 complement(1748392..1748398) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1748570..1750345) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /EC_number="3.6.1.12" /experiment="publication(s) with functional evidences, PMID:11886746, 16385024, 22200572, 25246477, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 16385024, 22200572, 25246477, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase" /protein_id="NP_389803.1" /db_xref="EnsemblGenomes-Gn:BSU19220" /db_xref="EnsemblGenomes-Tr:CAB13814" /db_xref="GOA:O34748" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002121" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR006293" /db_xref="InterPro:IPR010997" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018982" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032284" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13522" /db_xref="UniProtKB/Swiss-Prot:O34748" /translation="MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGG GKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLN GLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEI LFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKD RFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERF LNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLF SPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACG QCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLS TYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEAL KAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKG VGEQKRAKYGRLFLQEIQAYARMTD*" /label="recQ CDS" gene complement(1748570..1750345) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /label="recQ gene" S_feature complement(1750346..1750476) /Source="Nicolas_S_feature" /locus_tag="new_2095786_2095916_c" /HighExp="LoTm, G180, Cold, G135, G150, T5.0H, T4.0H, T3.30H, S2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S735" misc_RNA complement(1750469..1750671) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /product="6Sa RNA" /experiment="publication(s) with functional evidences, PMID:11886746, 15793584, 15811922, 22333917, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 15793584, 15811922, 22333917, 25576829, 26873600; Product type n : RNA" /label="ssrSA RNA" gene complement(1750469..1750671) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /label="ssrSA gene" downshifts complement(1750521) /Source="Nicolas_upshifts" /id="D1059" /incds=0 /nref=34 /ntot=297 /MaxReadThrough="4.06142" /MaxDrop="7.97725" /score="26.8190437" /energy="-12.7" /TU="U1566" /idTUdmin="U1568" /TUdmin=163 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1750669..1750688) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-10" upshifts complement(1750687) /Source="Nicolas_upshifts" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="upshifts" S_feature complement(1750689..1750881) /Source="Nicolas_S_feature" /locus_tag="new_2096129_2096321_c" /HighExp="dia5, Etha, dia15, Diami, S8, S7, C30, G180, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S736" promotor_-35 complement(1750701..1750708) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-35" CDS complement(1750910..1751536) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /EC_number="1.7.-.-" /experiment="publication(s) with functional evidences, PMID:11886746, 18208493, 22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 18208493, 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-dependent NADH-azoreductase" /protein_id="NP_389804.1" /db_xref="EnsemblGenomes-Gn:BSU19230" /db_xref="EnsemblGenomes-Tr:CAB13815" /db_xref="GOA:O35022" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13523" /db_xref="UniProtKB/Swiss-Prot:O35022" /translation="MSTVLFVKSSDRTAEEGVSTKLYEAFLAAYKENNPNDEVVELDL HKENLPYLGRDMINGTFKAGQGMEMTEDEKKQAAIADKYLNQFVKADKVVFAFPLWNF TVPAVLHTYVDYLSRAGVTFKYTQEGPVGLMGGKKVALLNARGGVYSEGPMAALEMSL NFMKTVLGFWGVQDLHTVVIEGHNAAPDQAQEIVEKGLQEAKDLAAKF*" /label="azoJ CDS" gene complement(1750910..1751536) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /label="azoJ gene" downshifts complement(1750926) /Source="Nicolas_upshifts" /id="D1060" /incds=0 /nref=68 /ntot=205 /MaxReadThrough="5.10353" /MaxDrop="5.66408" /score="1.15982687" /energy="-10.9" /TU="U1567,U1568" /idTUdmin="U1567" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1751570..1751589) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-10" upshifts complement(1751583) /Source="Nicolas_upshifts" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="upshifts" promotor_-35 complement(1751603..1751610) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-35" CDS complement(1751687..1752178) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 15496987, 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_389805.2" /db_xref="EnsemblGenomes-Gn:BSU19240" /db_xref="EnsemblGenomes-Tr:CAB13816" /db_xref="GOA:P80872" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR020458" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG13524" /db_xref="UniProtKB/Swiss-Prot:P80872" /translation="MALTKEQTQHLYHKLLDMQKELSGEKKETESMTEEVGELSNGVD NHMADHGTLVTDRMTDQTVKEIDRELLEEVNRALQKMKDGTYGVCEKTGQEIPYERLE AVPYARMTVEAQADVEDDLETDAPSYEREFHEQVKDLSNKETIDQKSSQTYEILDREQ DSK*" /label="yocK CDS" gene complement(1751687..1752178) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /label="yocK gene" downshifts complement(1751696) /Source="Nicolas_upshifts" /id="D1061" /incds=0 /nref=5 /ntot=49 /MaxReadThrough="7.79466" /MaxDrop="4.30433" /score="1.15982687" /energy="-10.9" /TU="U1568,U1573" /idTUdmin="U1571" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1752190..1752208) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-10" upshifts complement(1752202) /Source="Nicolas_upshifts" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="upshifts" promotor_-35 complement(1752222..1752228) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-35" CDS complement(1752253..1752585) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389806.1" /db_xref="EnsemblGenomes-Gn:BSU19250" /db_xref="EnsemblGenomes-Tr:CAB13817" /db_xref="SubtiList:BG13525" /db_xref="UniProtKB/Swiss-Prot:O34976" /translation="MKKMFRSLIRHCLKPELDKLRECEERLSVIEKQKQSSKQESEET YIHIETLNVEKVDYHLEFGELTIDELSGRLNIGATYYIPPEEKDKKCQRKPEAPSTPA VTIRSKRQ*" /label="yocL CDS" gene complement(1752253..1752585) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /label="yocL gene" S_feature complement(1752586..1752876) /Source="Nicolas_S_feature" /locus_tag="new_2098025_2098315_c" /HighExp="Salt, Cold, S3, S8, S4, S7, T5.0H, T3.30H, S6, T4.0H" /AntisenseName="yoyB" /AntisenseCor="0.489341986454357" /AntisenseRegPval="-16.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S737" promotor_-35 1752601..1752606 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-35" promotor_-10 1752621..1752639 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-10" upshifts 1752623 /Source="Nicolas_upshifts" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="upshifts" CDS 1752663..1752890 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097740.1" /db_xref="EnsemblGenomes-Gn:BSU19259" /db_xref="EnsemblGenomes-Tr:CAX52637" /db_xref="UniProtKB/Swiss-Prot:C0H429" /translation="MLPTNINISHLKTNSIGTGSSLTFGSAELRNRCSAIKRNNGFGE QNADGIVMVIPIESIDDRDVSDALSMKINHQ*" /label="yoyB CDS" gene 1752663..1752890 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /label="yoyB gene" CDS complement(1752877..1753353) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11150673, 23155385; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_389808.1" /db_xref="EnsemblGenomes-Gn:BSU19260" /db_xref="EnsemblGenomes-Tr:CAB13818" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG13526" /db_xref="UniProtKB/Swiss-Prot:O34321" /translation="MDFEKMKQWMEFAQQMYGGDFWKQVFDEDQKTPFMTNGQSPFPF AQQDQRGKGDASFPSMDIVDTVAEVQFLIYLPGYRKQDVHILSYGDYLVVKGQRFSYF NEQDFRQKEGKYGSFEKKIPLSDHLHGKMNAIFKDGILYITIQKDEGQAKTIVIDD*" /label="yocM CDS" gene complement(1752877..1753353) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /label="yocM gene" S_feature 1752891..1753398 /Source="Nicolas_S_feature" /locus_tag="new_2098330_2098837" /HighExp="S6, S5, S8, S7, S4, B36, BT, S3, T5.0H, LoTm" /AntisenseName="yocM" /AntisenseCor="0.54530996552252997" /AntisenseRegPval="-21.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.877" /TUlongSig="NA" /TUlongPSig="NA" /label="S738" S_feature complement(1753354..1753456) /Source="Nicolas_S_feature" /locus_tag="new_2098793_2098895_c" /HighExp="Cold, Salt, S8, T5.0H, S3, T-0.40H, T0.0H, S4, T4.0H, S6" /AntisenseName="yozN" /AntisenseCor="0.471443110130365" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S739" promotor_-35 1753371..1753376 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1753391..1753409 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1753400 /Source="Nicolas_upshifts" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="upshifts" CDS 1753420..1753683 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (mother cell in sporulation)" /protein_id="NP_389809.1" /db_xref="EnsemblGenomes-Gn:BSU19270" /db_xref="EnsemblGenomes-Tr:CAB13819" /db_xref="SubtiList:BG13761" /db_xref="UniProtKB/Swiss-Prot:O31846" /translation="MVQPTPYININIFMLKINSFENASAVNVGQNLLAEWQNSDKKNQ GYGQNFGDASGFMGTRSHVDDRDQIDSPASFESEAVNSSIKRK*" /label="yozN CDS" gene 1753420..1753683 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /label="yozN gene" promotor_-10 complement(1753436..1753455) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1753456) /Source="Nicolas_upshifts" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1753458..1753983) /Source="Nicolas_S_feature" /locus_tag="new_2098897_2099422_c" /HighExp="Salt, Cold, T-0.40H, T0.0H, T0.30H, T-1.10H, T-1.40H, T3.30H, T2.0H, S0" /AntisenseName="yocN" /AntisenseCor="-0.51964820699949898" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S740" promotor_-35 complement(1753469..1753473) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1753688..1753921 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (sporulation-related)" /protein_id="NP_389810.1" /db_xref="EnsemblGenomes-Gn:BSU19280" /db_xref="EnsemblGenomes-Tr:CAB13820" /db_xref="SubtiList:BG13527" /db_xref="UniProtKB/Swiss-Prot:O34855" /translation="MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGF GEENGDFTPLVVPISNVLDADLVDSNSAKNSVV*" /label="yocN CDS" gene 1753688..1753921 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /label="yocN gene" downshifts 1753908 /Source="Nicolas_upshifts" /id="D1062" /incds=0 /nref=62 /ntot=90 /MaxReadThrough="2.0117" /MaxDrop="7.59451" /score="5.68120132" /energy="-10.9" /TU="NA" /idTUdmin="U1570" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1754007..1754351) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved hypothetical phage protein" /protein_id="NP_389811.1" /db_xref="EnsemblGenomes-Gn:BSU19290" /db_xref="EnsemblGenomes-Tr:CAB13821" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13762" /db_xref="UniProtKB/Swiss-Prot:O31847" /translation="MGIFSVSRSTDAKKLEALLVEGERIESIYKLRVDQICFTNKRII FFDNKMFSKKKVRVFLPYKTIESFAIQEAGMFDPDTGLLLMTRSKTFELEFAKDTDLS EVQAVLTKHLCS*" /label="yozO CDS" gene complement(1754007..1754351) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /label="yozO gene" downshifts complement(1754028) /Source="Nicolas_upshifts" /id="D1063" /incds=0 /nref=61 /ntot=217 /MaxReadThrough="4.58642" /MaxDrop="4.1868" /score="12.6520239" /energy="-9.6" /TU="U1572,U1573" /idTUdmin="U1574" /TUdmin=616 /isTUend="FALSE" /label="downshifts" S_feature complement(1754352..1754424) /Source="Nicolas_S_feature" /locus_tag="new_2099791_2099863_c" /HighExp="T0.30H, T0.0H, T1.0H, T-0.40H, T1.30H, T-1.10H, Salt, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S741" promotor_-10 complement(1754420..1754439) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1754424) /Source="Nicolas_upshifts" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1754426..1754529) /Source="Nicolas_S_feature" /locus_tag="new_2099865_2099968_c" /HighExp="T0.30H, T0.0H, T-0.40H, T1.0H, T1.30H, Salt, T-1.10H, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S742" promotor_-35 complement(1754453..1754458) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1754516..1754531) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1754529) /Source="Nicolas_upshifts" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1754544..1754553) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1754672) /Source="Nicolas_upshifts" /id="D1064" /incds=0 /nref=117 /ntot=269 /MaxReadThrough="5.5406" /MaxDrop="6.72115" /score="36.7697843" /energy="-10.7" /TU="U1574" /idTUdmin="U1576" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1754708..1754911) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389812.1" /db_xref="EnsemblGenomes-Gn:BSU19300" /db_xref="EnsemblGenomes-Tr:CAB13822" /db_xref="SubtiList:BG13750" /db_xref="UniProtKB/Swiss-Prot:O31848" /translation="MIHKNWLEKETIKKVKCVQTNAKKYIVNRVLTPGKEYEVKNETE EFLFVVDNTNKVGGYYKEYFEEM*" /label="yozC CDS" gene complement(1754708..1754911) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /label="yozC gene" promotor_-10 complement(1754932..1754951) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1754950) /Source="Nicolas_upshifts" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1754952..1755018) /Source="Nicolas_S_feature" /locus_tag="new_2100391_2100457_c" /HighExp="S7, S8, S6, S5, C30, S4, T4.0H, B60, BC, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.461" /TUlongSig="NA" /TUlongPSig="NA" /label="S743" promotor_-35 complement(1754967..1754974) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1754984..1754991 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-35" upshifts 1755003 /Source="Nicolas_upshifts" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="upshifts" misc_feature complement(1755005..1755017) /Source="Nicolas_upshift_promotors" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1755005..1755024 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-10" S_feature 1755008..1755140 /Source="Nicolas_S_feature" /locus_tag="new_2100447_2100579" /HighExp="BC, M0t90, M9-stat, S2, T2.30H, Sw, Lbstat, M40t90, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S744" upshifts complement(1755029) /Source="Nicolas_upshifts" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="upshifts" CDS 1755141..1756628 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /EC_number="1.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17555270, 23874669, 25409630, 26337367, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17555270, 23874669, 25409630, 26337367, 27797724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxypropionaldehyde dehydrogenase" /protein_id="NP_389813.1" /db_xref="EnsemblGenomes-Gn:BSU19310" /db_xref="EnsemblGenomes-Tr:CAB13823" /db_xref="GOA:O34660" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12582" /db_xref="UniProtKB/Swiss-Prot:O34660" /translation="MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPAT GETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELA QLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGV VGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVIN IIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILL PDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLH KDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMT IAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVW VNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED*" /label="dhaS CDS" gene 1755141..1756628 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /label="dhaS gene" promotor_-10 complement(1755584..1755601) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1755590) /Source="Nicolas_upshifts" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1755614..1755622) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1756614 /Source="Nicolas_upshifts" /id="D1065" /incds=0 /nref=163 /ntot=260 /MaxReadThrough="3.66831" /MaxDrop="7.01026" /score="24.6079855" /energy="-7.1" /TU="U1575" /idTUdmin="U1575" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1756676..1756681 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1756697..1756715 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1756702 /Source="Nicolas_upshifts" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="upshifts" CDS 1756729..1758627 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /EC_number="4.2.1.137" /EC_number="5.4.99.17" /function="16.13: Shape" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2253626, 18436644, 18630919, 21627333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2253626, 18436644, 18630919, 21627333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="squalene-hopene cyclase, sporulenol synthase (spore protection)" /protein_id="NP_389814.2" /db_xref="EnsemblGenomes-Gn:BSU19320" /db_xref="EnsemblGenomes-Tr:CAB13824" /db_xref="GOA:Q796C3" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR018333" /db_xref="InterPro:IPR032696" /db_xref="InterPro:IPR032697" /db_xref="SubtiList:BG12679" /db_xref="UniProtKB/Swiss-Prot:Q796C3" /translation="MGTLQEKVRRFQKKTITELRDRQNADGSWTFCFEGPIMTNSFFI LLLTSLDEGENEKELISSLAAGIHAKQQPDGTFINYPDETRGNLTATVQGYVGMLASG CFHRTEPHMKKAEQFIISHGGLRHVHFMTKWMLAANGLYPWPALYLPLSLMALPPTLP IHFYQFSSYARIHFAPMAVTLNQRFVLINRNISSLHHLDPHMTKNPFTWLRSDAFEER DLTSILLHWKRVFHAPFAFQQLGLQTAKTYMLDRIEKDGTLYSYASATIYMVYSLLSL GVSRYSPIIRRAITGIKSLVTKCNGIPYLENSTSTVWDTALISYALQKNGVTETDGSV TKAADFLLERQHTKIADWSVKNPNSVPGGWGFSNINTNNPDCDDTTAVLKAIPRNHSP AAWERGVSWLLSMQNNDGGFSAFEKNVNHPLIRLLPLESAEDAAVDPSTADLTGRVLH FLGEKVGFTEKHQHIQRAVKWLFEHQEQNGSWYGRWGVCYIYGTWAALTGMHACGVDR KHPGIQKALRWLKSIQNDDGSWGESCKSAEIKTYVPLHRGTIVQTAWALDALLTYENS EHPSVVKGMQYLTDSSSHSADSLAYPAGIGLPKQFYIRYHSYPYVFSLLAVGKYLDSI EKETANET*" /label="sqhC CDS" gene 1756729..1758627 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /label="sqhC gene" promotor_-10 complement(1757672..1757691) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1757680) /Source="Nicolas_upshifts" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1757705..1757714) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1758617..1759462 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /EC_number="1.15.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 20233928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Fe2+-dependent)" /protein_id="NP_389815.1" /db_xref="EnsemblGenomes-Gn:BSU19330" /db_xref="EnsemblGenomes-Tr:CAB13825" /db_xref="GOA:O35023" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="SubtiList:BG12676" /db_xref="UniProtKB/Swiss-Prot:O35023" /translation="MKRESYQAEMFNWCEALKDQIQKRGQLDQFEDQIDKMIEALEDD QTTEEDWYKQAAALYRDITESDDTSERRAYVPIGKHVLPKLPYKYSALEPYISRDIMI LHHTKHHQSYVDGLNKAESELKKARATKNYDLITHWERELAFHGAGHYLHSIFWFSMH PNGKRRPTGALFQMIDLSFGSYSAFKEHFTQASKKVEGVGWAILVWAPRSGRLEILTA EKHQLFSQWDVIPLLPLDVWEHAYYLQYKNDRASYVDHWWNVVDWREAEKRFEQAKEV VWKLY*" /label="sodF CDS" gene 1758617..1759462 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /label="sodF gene" S_feature 1759463..1760969 /Source="Nicolas_S_feature" /locus_tag="new_2104902_2106408" /HighExp="S5, S6, S4, S8, S3, S7, T5.0H, B36, BT, T4.0H" /AntisenseName="yocR" /AntisenseCor="-0.62866346519731298" /AntisenseRegPval="-30.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S745" CDS complement(1759495..1760832) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_389816.1" /db_xref="EnsemblGenomes-Gn:BSU19340" /db_xref="EnsemblGenomes-Tr:CAB13826" /db_xref="GOA:O34383" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13528" /db_xref="UniProtKB/Swiss-Prot:O34383" /translation="MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLL IFILFTVLIGLPLLLGEFIIGRRTQKDAVQSYKTLAPGTKWHWIGYLGMVTCFILLSF YSVVGGWILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKG VSSGIEKASQVLMPALFLLFIILMVRSVTLDGAMEGIKFFLMPDLTAIDANTILYAMG QSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIFPAVFSFGLK PDQGPVLLFNVLPTVFNQMPFGIIFLLAFLLLFLFAALTSAFSMLEILVAVLSKGDIN KRKRFAWLGGIAIFIVGVPSALSYGVLSDVTIFHLSIFDAADYLVSNILMPLGALLIS IFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVAIIIVFLHVIGIF*" /label="yocR CDS" gene complement(1759495..1760832) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /label="yocR gene" downshifts complement(1759506) /Source="Nicolas_upshifts" /id="D1066" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="0.83968" /MaxDrop="2.44824" /score="27.8372036" /energy="-11.1" /TU="NA" /idTUdmin="U1580" /TUdmin=154 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1760860..1760879) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1760875) /Source="Nicolas_upshifts" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1760877..1762035) /Source="Nicolas_S_feature" /locus_tag="new_2106316_2107474_c" /HighExp="M9-stat, T1.30H, B60, T1.0H, T2.0H, T0.30H, T2.30H, T3.0H, T3.30H, Etha" /AntisenseName="yocS" /AntisenseCor="-6.3575129468026695E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S746" promotor_-35 complement(1760894..1760901) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1760953..1760956 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1760971..1760990 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1760971 /Source="Nicolas_upshifts" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="upshifts" CDS 1761051..1762016 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent symporter" /protein_id="NP_389817.1" /db_xref="EnsemblGenomes-Gn:BSU19350" /db_xref="EnsemblGenomes-Tr:CAB13827" /db_xref="GOA:O34524" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG13529" /db_xref="UniProtKB/Swiss-Prot:O34524" /translation="MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFL GIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGV ILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPG SLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENL LQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAH FSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL*" /label="yocS CDS" gene 1761051..1762016 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /label="yocS gene" downshifts 1762004 /Source="Nicolas_upshifts" /id="D1067" /incds=0 /nref=42 /ntot=166 /MaxReadThrough="3.53218" /MaxDrop="5.09676" /score="30.279305" /energy="-16.4" /TU="U1581" /idTUdmin="U1581" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1762066..1763319) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /EC_number="2.3.1.61" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417, 22720735, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417, 22720735, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit)" /protein_id="NP_389818.2" /db_xref="EnsemblGenomes-Gn:BSU19360" /db_xref="EnsemblGenomes-Tr:CAB13828" /db_xref="GOA:P16263" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR006255" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10273" /db_xref="UniProtKB/Swiss-Prot:P16263" /translation="MAEIKVPELAESISEGTIAQWLKQPGDYVEQGEYLLELETDKVN VELTAEESGVLQEVLKDSGDTVQVGEIIGTISEGAGESSAPAPTEKTESKESVKEEKQ AEPAAQEVSEEAQSEAKSRTIASPSARKLAREKGIDLSQVPTGDPLGRVRKQDVEAYE KPASKPAPQQKQQPQAQKAQQSFDKPVEVQKMSRRRQTIAKRLVEVQQTSAMLTTFNE VDMTAVMNLRKRRKDQFFEQNEVKLGFMSFFTKAVVAALKKYPLLNAEIQGDELIVKK FYDIGIAVAADEGLVVPVVRDADRLTFAGIEKEIGELAKKARNNKLTLSELQGGSFTI TNGGTFGSLMSTPILNSPQVGILGMHKIQLRPVAIDEERFENRPMMYIALSYDHRIVD GKEAVGFLVTIKNLLEDPEQLLLEG*" /label="odhB CDS" gene complement(1762066..1763319) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /label="odhB gene" downshifts complement(1762080) /Source="Nicolas_upshifts" /id="D1068" /incds=0 /nref=200 /ntot=253 /MaxReadThrough="5.25481" /MaxDrop="7.42366" /score="11.7726103" /energy="-16.4" /TU="U1582" /idTUdmin="U1582" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" CDS complement(1763335..1766169) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /EC_number="1.2.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase (E1 subunit)" /protein_id="NP_389819.3" /db_xref="EnsemblGenomes-Gn:BSU19370" /db_xref="EnsemblGenomes-Tr:CAB13829" /db_xref="GOA:P23129" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR011603" /db_xref="InterPro:IPR023784" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR031717" /db_xref="InterPro:IPR032106" /db_xref="SubtiList:BG10272" /db_xref="UniProtKB/Swiss-Prot:P23129" /translation="MFQNSMKQRMNWEDFYGPNLGYALELYDQYTQDPNSIDPDLKEM FDELGAPPSDIKEASGTKEKGRVTADLIQKIASAVRLAEDIRTYGHLNASVNPLRKDE KKSELFPLSDYGLTEEEIKAIPASVICKDAPKNISNGLEAIQYLRNTYKRTISFEFDH VHDFKEREWLTRKIESGELFQKNSAEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIE GLDALVPVLDDIIAQSVKSGTTSVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNK DLVPSEGSIGISYGWTGDVKYHLGANRELQDAETKSARITLANNPSHLEFINPIVEGS TRAAQETRTQSGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHI IANNMIGFTTESAESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKTFN KDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKQIFAEKLVKEGVVTEEVVQ NIEKSVTKRIEDAYQKVPSKKEHTACEIELPEPVSNGFPDVDTSIDFDVLRKLNGELI NWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSER GTFAQRNLVLHDSETGKEFVPLHHLSDCSTSFAVHNSPLSEGSVLGFEYGYNVHSPET LVLWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRIER FLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEV QELSESRFQPVYEQSGLSHDYEKVTRLVLSSGKVSIDISDHFNKLEDGKEWLHIARIE QLYPFPAKGVKELFAKLPNLKEIVWVQEEPQNMGAWGYISPYLTEIAPEGVSVQYIGR RRRSSPAEGDPTVHKKEQERIVSDSLTRKN*" /label="odhA CDS" gene complement(1763335..1766169) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /label="odhA gene" promotor_-10 complement(1766264..1766283) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1766279) /Source="Nicolas_upshifts" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1766281..1766397) /Source="Nicolas_S_feature" /locus_tag="new_2111720_2111836_c" /HighExp="dia15, G150, G135, H2O2, Lbexp, dia0, Oxctl, LBGtran, G180, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S747" promotor_-35 complement(1766298..1766305) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1766398..1768314) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23087684; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative activator of nitric oxide reductase" /protein_id="NP_389820.2" /db_xref="EnsemblGenomes-Gn:BSU19380" /db_xref="EnsemblGenomes-Tr:CAB13830" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG13567" /db_xref="UniProtKB/Swiss-Prot:O31849" /translation="MKFIKFNDSTIDSFLFMMLTDLAKTLTKSEAVEVEYGVQSYYNP FEKKIYMSHFWKDRAAEDMEAGLKSDVYLRSVGTRYSSLHEFANFLNDIHRHLTFKSF AKQLFMLLEDIRIEECIKRERPGTKHVFAKRKDMYRKHFSTQLTLNLERSIFTDALFC AIYFKLTAESPLETLPSMREDIDLMRPFIEQQLLRVYEADSTRQVLKIVEDLMDGLEE VLDKDMLNTYFFLPELDYAKAAEQPLFEEEKKAPKLSDDITLPKQSDGDEDIHEEEMP TWHRETEAPSKSFLQFDIEHGAKSDLGKDASREGDDGDQALGSVQGSARQTKRKDYSK LEALESQKDQPNGAGMADGKENKYAFPIYKEPQPATSEEELSYKQQAKTIESYQKRLK QMIQKTLEHKKTLPRTDLHAGRLNNKLLRYFTERNPRLFYKKQEPSSEIDAVFTLLVD CSASMFDKMDETKRGIVLFHEALKSVAVPHQIVGFWEDTNDATEKSQPNYFNTVIPFQ SSLRQDSGPAIMQLEPEEDNRDGYAIRQMTKKMLHRSEAQKFLIVFSDGEPAAFGYEQ NGIVDTSEAVIEARKRGIEVINVFLSNSEIEESQMKTIQDMYGKFSIFVPDVDQLPDV LYPLLKKLLHKSIG*" /label="yojO CDS" gene complement(1766398..1768314) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /label="yojO gene" CDS complement(1768325..1769239) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15491156, 23087684; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nitric-oxide reductase associated protein" /protein_id="NP_389821.1" /db_xref="EnsemblGenomes-Gn:BSU19390" /db_xref="EnsemblGenomes-Tr:CAB13831" /db_xref="GOA:O31850" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13566" /db_xref="UniProtKB/Swiss-Prot:O31850" /translation="MNRKGNLSMTTQLQHLTLPEDIQQKLLSYKEQPISPEFQSLIGT SGYEAEDEAILFDAIIALAMGKNVLLKGPTGSGKTKLAETLSSYFHKPMHSVNCSVDL DAEALVGYKTIENQSGQATIEFVSGPVTKAMKEGHFLYIDEINMAKPETLPILNGVLD YRKMMTNPFTGEVIRAKSGFGVIAAINEGYVGTVPLNEALKNRFVIIDVPYIKGELLK QVLMSQSALKDEKLIDRFITLSSDLIVQANNGQVSEEAASIRALIDTCDLAAYIPPRR AIERGIVEKLDDDREKAAVRNIAETLFE*" /label="yojN CDS" gene complement(1768325..1769239) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /label="yojN gene" promotor_-10 complement(1769243..1769262) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-10" upshifts complement(1769258) /Source="Nicolas_upshifts" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="upshifts" promotor_-35 complement(1769279..1769283) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-35" CDS complement(1769303..1769893) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /EC_number="1.15.1.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15897454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15897454; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="superoxide dismutase (exported lipoprotein)" /protein_id="NP_389822.1" /db_xref="EnsemblGenomes-Gn:BSU19400" /db_xref="EnsemblGenomes-Tr:CAB13832" /db_xref="GOA:O31851" /db_xref="InterPro:IPR001424" /db_xref="InterPro:IPR024134" /db_xref="InterPro:IPR036423" /db_xref="PDB:1S4I" /db_xref="PDB:1U3N" /db_xref="PDB:1XTL" /db_xref="PDB:1XTM" /db_xref="SubtiList:BG13565" /db_xref="UniProtKB/Swiss-Prot:O31851" /translation="MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHH VQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAG GPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDG SAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ*" /label="sodC CDS" gene complement(1769303..1769893) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /label="sodC gene" CDS complement(1769986..1771230) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /EC_number="3.5.1.-" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 22139507" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 22139507; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan hydrolase (cell wall-binding d,l-endopeptidase)" /protein_id="NP_389823.1" /db_xref="EnsemblGenomes-Gn:BSU19410" /db_xref="EnsemblGenomes-Tr:CAB13833" /db_xref="GOA:O31852" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13564" /db_xref="UniProtKB/Swiss-Prot:O31852" /translation="MKKKIVAGLAVSAVVGSSMAAAPAEAKTIKVKSGDSLWKLSRQY DTTISALKSENKLKSTVLYVGQSLKVPESSKKSTTSPSNSSKTSTYTVAYGDSLWMIA KNHKMSVSELKSLNSLSSDLIRPGQKLKIKGTSSSSGSNGSKKNSGSNSSGSSKSTYT VKLGDSLWKIANSLNMTVAELKTLNGLTSDTLYPKQVLKIKGSSSPKNGNSGSKKPSN SNPSKTTTYKVKAGDSLWKIANRLGVTVQSIRDKNNLSSDVLQIGQVLTISGASKSNP SNPTKPTKPKDNSGSNIQIGSKIDRMITEAKKYVGVPYRWGGNTPAGFDCSGFIYYLI NNVSSISRLSTAGYWNVMQKVSQPSVGDFVFFTTYKSGPSHMGIYLGGGDFIHASSSG VDISNLSNSYWKQRYLGARSYF*" /label="cwlS CDS" gene complement(1769986..1771230) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /label="cwlS gene" downshifts complement(1769988) /Source="Nicolas_upshifts" /id="D1069" /incds=0 /nref=20 /ntot=183 /MaxReadThrough="4.09529" /MaxDrop="3.77828" /score="11.0350171" /energy="-4.7" /TU="U1584,U1585" /idTUdmin="U1585" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1771293..1771311) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1771306) /Source="Nicolas_upshifts" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1771308..1771528) /Source="Nicolas_S_feature" /locus_tag="new_2116747_2116967_c" /HighExp="S2, Lbstat, T2.30H, M0t90, HiOs, T3.0H, Etha, M40t90, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S748" promotor_-35 complement(1771324..1771331) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1771514..1771532) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1771528) /Source="Nicolas_upshifts" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1771544..1771552) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1771612..1772829) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /EC_number="2.4.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative YDP-glycosyltransferase" /protein_id="NP_389824.2" /db_xref="EnsemblGenomes-Gn:BSU19420" /db_xref="EnsemblGenomes-Tr:CAB13834" /db_xref="GOA:O31853" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG13563" /db_xref="UniProtKB/Swiss-Prot:O31853" /translation="MANVLMIGFPGEGHINPSIGVMKELKSRGENITYYAVKEYKEKI TALDIEFREYHDFRGDYFGKNATGDEERDFTEMLCAFLKACKDIATHIYEEVKHESYD YVIYDHHLLAGKVIANMLKLPRFSLCTTFAMNEEFAKEMMGAYMKGSLEDSPHYESYQ QLAETLNADFQAEIKKPFDVFLADGDLTIVFTSRGFQPLAEQFGERYVFVGPSITERA GNNDFPFDQIDNENVLFISMGTIFNNQKQFFNQCLEVCKDFDGKVVLSIGKHIKTSEL NDIPENFIVRPYVPQLEILKRASLFVTHGGMNSTSEGLYFETPLVVIPMGGDQFVVAD QVEKVGAGKVIKKEELSESLLKETIQEVMNNRSYAEKAKEIGQSLKAAGGSKKAADSI LEAVKQKTQSANA*" /label="yojK CDS" gene complement(1771612..1772829) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /label="yojK gene" downshifts complement(1771638) /Source="Nicolas_upshifts" /id="D1070" /incds=0 /nref=14 /ntot=145 /MaxReadThrough="1.49168" /MaxDrop="4.07727" /score="9.41396656" /energy="-14.4" /TU="NA" /idTUdmin="U1586" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1772862..1772881) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1772870) /Source="Nicolas_upshifts" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1772895..1772902) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1773065..1773688) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /EC_number="2.7.7.85" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:21566650, 23192352, 24939848, 27252699, 27790204, 28751888" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21566650, 23192352, 24939848, 27252699, 27790204, 28751888; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore diadenylate cyclase" /protein_id="NP_389825.3" /db_xref="EnsemblGenomes-Gn:BSU19430" /db_xref="EnsemblGenomes-Tr:CAB13835" /db_xref="GOA:O31854" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR019457" /db_xref="InterPro:IPR034693" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG13562" /db_xref="UniProtKB/Swiss-Prot:O31854" /translation="MKAMRYEQISENAFKGKIQVYLEQILGDASLILKTLHEKDQCLL CELDDLGHVFQDMQGIASSFYLQSYIEEFTPAFIELAKAIKALSEHKHGALIVIERAD PVERFIQKGTSLHAEISSSLIESIFFPGNPLHDGALLVRENKLVSAANVLPLTTKEVD IHLGTRHRAALGMSGYTDALVLVVSEETGKMSFAKDGVLYPLISPRT*" /label="cdaS CDS" gene complement(1773065..1773688) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /label="cdaS gene" S_feature complement(1773689..1773839) /Source="Nicolas_S_feature" /locus_tag="new_2119128_2119278_c" /HighExp="S8, S5, S7, S6, Etha, S4, M9-stat, S3, C30, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S749" promotor_-35 1773715..1773721 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1773727 /Source="Nicolas_upshifts" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1773735..1773746 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1773753..1773761 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1773769..1773869 /Source="Nicolas_upshift_promotors" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 1773773..1773791 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1773784 /Source="Nicolas_upshifts" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1773822..1773840) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1773829..1773914 /Source="Nicolas_S_feature" /locus_tag="new_2119268_2119353" /HighExp="S8, S7, S4, S5, S6, BT, S3, T5.0H, S2, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigGF" /TUshortPSig="0.00699, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S750" upshifts 1773829 /Source="Nicolas_upshifts" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1773839) /Source="Nicolas_upshifts" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1773856..1773862) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1773890..1773897 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1773910..1773929 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1773916 /Source="Nicolas_upshifts" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="upshifts" CDS 1773954..1775312 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14766544, 15849754, 15855508, 16850406, 16954325, 17114254; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+-driven efflux MatE family protein" /protein_id="NP_389826.1" /db_xref="EnsemblGenomes-Gn:BSU19440" /db_xref="EnsemblGenomes-Tr:CAB13836" /db_xref="GOA:O31855" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13561" /db_xref="UniProtKB/Swiss-Prot:O31855" /translation="MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSP ADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLS IAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKT RVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKN APFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIAS HQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAA CILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLA AAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQ HI*" /label="mdtK CDS" gene 1773954..1775312 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /label="mdtK gene" promotor_-10 complement(1774296..1774307) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1774301) /Source="Nicolas_upshifts" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1774321..1774327) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1775328..1776176 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665, 20935101, 22287516, 24599254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665, 20935101, 22287516, 24599254; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-antagonist of RsbT; component of the anxiosome (stressosome)" /protein_id="NP_389827.1" /db_xref="EnsemblGenomes-Gn:BSU19450" /db_xref="EnsemblGenomes-Tr:CAB13837" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG13560" /db_xref="UniProtKB/Swiss-Prot:O31856" /translation="MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIH NLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRD LYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDM ITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVI DTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASD LKLKKV*" /label="rsbRC CDS" gene 1775328..1776176 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /label="rsbRC gene" promotor_-10 complement(1775592..1775611) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1775599) /Source="Nicolas_upshifts" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1775625..1775633) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1776139 /Source="Nicolas_upshifts" /id="D1071" /incds=0 /nref=10 /ntot=138 /MaxReadThrough="1.62054" /MaxDrop="3.13267" /score="12.3887642" /energy="-14" /TU="NA" /idTUdmin="U1591" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1776171) /Source="Nicolas_upshifts" /id="D1072" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="1.55562" /MaxDrop="4.60101" /score="23.8391861" /energy="-13.7" /TU="NA" /idTUdmin="U1594" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1776202..1776867) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /EC_number="3.5.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15136574, 20308541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15136574, 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate N-acetylglucosamine deacetylase (second enzyme)" /protein_id="YP_054582.2" /db_xref="EnsemblGenomes-Gn:BSU19460" /db_xref="EnsemblGenomes-Tr:CAB13838" /db_xref="GOA:O31857" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023841" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG13559" /db_xref="UniProtKB/Swiss-Prot:O31857" /translation="MKEHVLVILPHPDDESYGVAGLIALNRKKDIPVTYACATLGEMG RNMGDPFFANRETLPLLRKQELINACKEMDINDLRMLGLRDKTLEFEDDEYLADIMEE IIDDVKPSLIVTFYPGHGVHPDHDACGEAVIRALYRKKKEDRPRTICMAITRNREEVL GEADVVLDIKEVADIKMNALRAHRTQTEGMLRELEEKLKNNEPVMATWFEEEIYWTYQ WND*" /label="bshBB CDS" gene complement(1776202..1776867) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /label="bshBB gene" downshifts complement(1776216) /Source="Nicolas_upshifts" /id="D1073" /incds=0 /nref=189 /ntot=251 /MaxReadThrough="3.68743" /MaxDrop="7.13247" /score="23.8391861" /energy="-13.7" /TU="U1594" /idTUdmin="U1596" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1776886..1777236) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (bacillithiol synthesis operon)" /protein_id="NP_389829.1" /db_xref="EnsemblGenomes-Gn:BSU19470" /db_xref="EnsemblGenomes-Tr:CAB13839" /db_xref="InterPro:IPR014934" /db_xref="InterPro:IPR036492" /db_xref="PDB:1NJH" /db_xref="SubtiList:BG13558" /db_xref="UniProtKB/Swiss-Prot:O31858" /translation="MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVV AYIRNAKVTYHQAKIKGNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGK LAISLQISEKPFTV*" /label="yojF CDS" gene complement(1776886..1777236) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /label="yojF gene" CDS complement(1777233..1777511) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097741.1" /db_xref="EnsemblGenomes-Gn:BSU19479" /db_xref="EnsemblGenomes-Tr:CAX52638" /db_xref="UniProtKB/Swiss-Prot:O68260" /translation="MDNDKEIVKAYASLWNNRSLAHDDAEAVAEAIDLELLDKRTHPR LRKPMLEKYFAAIQRIVNSQLEPAVKYQLVKLHTERAEYLKEERGEQS*" /label="yoyC CDS" gene complement(1777233..1777511) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /label="yoyC gene" promotor_-10 complement(1777538..1777557) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1777554) /Source="Nicolas_upshifts" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1777572..1777578) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1777587..1778483) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636, 23944997; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative N-acetylated toxic metabolites" /protein_id="NP_389830.2" /db_xref="EnsemblGenomes-Gn:BSU19480" /db_xref="EnsemblGenomes-Tr:CAB13840" /db_xref="GOA:O31859" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004626" /db_xref="SubtiList:BG13557" /db_xref="UniProtKB/Swiss-Prot:O31859" /translation="MQHAETKKGVIYTAVSFIMWGLFPLYWKLLEQLPALDILAHRII WSFVFMCIVLFFLRQWKIGWQELRSLKKNGGILSLFLASILISINWFVYIWAVNHGFL LEASLGYYINPLVSVLLGILFLKEKLNRLQLVAVSIAAAGVIISAFQYGSIPYVALLL AFSFGLYGLSKKRTSLPSAIGLTLETFMIMPIALGYLLFSGHVQPAGAESGGTWLLLF LAGVFTALPLLLFAEGAKRLPLYQVGILQYIAPTITLLIGLFVYHEPFSSSKAFTFSC IWAALLLFTFSQVKWKRASKSH*" /label="yojE CDS" gene complement(1777587..1778483) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /label="yojE gene" promotor_-35 1778325..1778334 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1778345 /Source="Nicolas_upshifts" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1778348..1778367 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1778363..1778581 /Source="Nicolas_S_feature" /locus_tag="new_2123802_2124020" /HighExp="S6, S8, S7, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="yojE" /AntisenseCor="-0.562105310907978" /AntisenseRegPval="-23.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S751" promotor_-10 complement(1778507..1778526) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1778527) /Source="Nicolas_upshifts" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1778538..1778545) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1778582..1779055 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17720779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17720779; Product type s: structure" /codon_start=1 /transl_table=11 /product="component of the spore coat" /protein_id="YP_054583.1" /db_xref="EnsemblGenomes-Gn:BSU19490" /db_xref="EnsemblGenomes-Tr:CAE01457" /db_xref="GOA:Q7WY67" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG14190" /db_xref="UniProtKB/Swiss-Prot:Q7WY67" /translation="MFEWNKYFPFHNQFSKEALKKADPKEVETYVNRVMESVFGSDYA AQFPFRDPLPQKEHPAKPDAKPDVKPDIDIFETADHVFVKVPISEEWLEQVRIKHTSH ELWLENLPRADHPKKVNLPCLVKRKGTKAVYKDGLLEVMFQKQQDYNMSEVEIIR*" /label="gerT CDS" gene 1778582..1779055 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /label="gerT gene" downshifts 1779052 /Source="Nicolas_upshifts" /id="D1074" /incds=0 /nref=23 /ntot=53 /MaxReadThrough="-0.0703700000000005" /MaxDrop="9.27889" /score="40.8456275" /energy="-16.6" /TU="NA" /idTUdmin="U1595" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1779090..1779326) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389832.1" /db_xref="EnsemblGenomes-Gn:BSU19510" /db_xref="EnsemblGenomes-Tr:CAB13842" /db_xref="GOA:O31861" /db_xref="SubtiList:BG13555" /db_xref="UniProtKB/Swiss-Prot:O31861" /translation="MYPHHSYLRGIPGPAGYPARSPFLFGAPLVGGLLGGFLGSALFN YSRPYAYPPGPYGYGGGPYGFGAGVPYGGYPGFY*" /label="yojB CDS" gene complement(1779090..1779326) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /label="yojB gene" downshifts complement(1779098) /Source="Nicolas_upshifts" /id="D1075" /incds=0 /nref=37 /ntot=68 /MaxReadThrough="2.10188" /MaxDrop="7.8003" /score="35.4403926" /energy="-16.6" /TU="NA" /idTUdmin="U1597" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1779349..1779368) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1779364) /Source="Nicolas_upshifts" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1779382..1779391) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1779411..1780745) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 3020045, 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/anion permease" /protein_id="NP_389833.1" /db_xref="EnsemblGenomes-Gn:BSU19520" /db_xref="EnsemblGenomes-Tr:CAB13843" /db_xref="GOA:O31862" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG13554" /db_xref="UniProtKB/Swiss-Prot:O31862" /translation="MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDIN KIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVV VASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAP TAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRK EFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISL LLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADF FRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAG SVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM*" /label="yojA CDS" gene complement(1779411..1780745) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /label="yojA gene" S_feature complement(1780746..1780881) /Source="Nicolas_S_feature" /locus_tag="new_2126185_2126320_c" /HighExp="M0t90, M40t90, Lbtran, S1, dia5, Mt0, T0.0H, BI, Lbstat, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25781100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S752" promotor_-10 complement(1780878..1780897) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1780888) /Source="Nicolas_upshifts" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1780912..1780919) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1780977..1780984 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1780999..1781018 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1781002 /Source="Nicolas_upshifts" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1781003..1781109 /Source="Nicolas_S_feature" /locus_tag="new_2126442_2126548" /HighExp="M0t90, M40t90, LoTm, Salt, Cold, BI, HPh, LBGstat, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S753" CDS 1781110..1781499 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /EC_number="5.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_389834.1" /db_xref="EnsemblGenomes-Gn:BSU19530" /db_xref="EnsemblGenomes-Tr:CAB13844" /db_xref="GOA:O34882" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG13530" /db_xref="UniProtKB/Swiss-Prot:O34882" /translation="MPLLRFDVIEGRDEKSLQLLLDTAHQAMVEAFGVPERDRYQIVH QHPANELIIQDAGLGFQRTKDMVIISMTSKARTESQKEKLYALLAERLEKKCEISPDD LMVSITENGDADWSFGLGEAQFLNGKL*" /label="yodA CDS" gene 1781110..1781499 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /label="yodA gene" downshifts 1781509 /Source="Nicolas_upshifts" /id="D1076" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.20831" /MaxDrop="2.65754" /score="14.4455719" /energy="-13.2" /TU="NA" /idTUdmin="U1599" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1781906..1782244) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17158660, 18208493, 20652907, 27531959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17158660, 18208493, 20652907, 27531959; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_389835.1" /db_xref="EnsemblGenomes-Gn:BSU19540" /db_xref="EnsemblGenomes-Tr:CAB13845" /db_xref="GOA:O34844" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:5HS7" /db_xref="PDB:5HS8" /db_xref="PDB:5HS9" /db_xref="SubtiList:BG13531" /db_xref="UniProtKB/Swiss-Prot:O34844" /translation="MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPM ISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCE PGDTVCEEEK*" /label="arxR CDS" gene complement(1781906..1782244) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /label="arxR gene" promotor_-35 1782267..1782274 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1782288..1782307 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1782297 /Source="Nicolas_upshifts" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="upshifts" S_feature 1782301..1782373 /Source="Nicolas_S_feature" /locus_tag="new_2127740_2127812" /HighExp="dia5, Diami, dia15, Salt, Lbtran, Heat, HiOs, S1, aero, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S754" promotor_-10 complement(1782332..1782351) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1782335) /Source="Nicolas_upshifts" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1782363..1782369) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1782374..1782982 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /EC_number="1.6.99.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 21749987, 24525333, 26312069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="water forming NADH oxidase (nitroreductase)" /protein_id="NP_389836.1" /db_xref="EnsemblGenomes-Gn:BSU19550" /db_xref="EnsemblGenomes-Tr:CAB13846" /db_xref="GOA:P81102" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG13532" /db_xref="UniProtKB/Swiss-Prot:P81102" /translation="MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNL QHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGY ITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKE QFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL*" /label="noxC CDS" gene 1782374..1782982 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /label="noxC gene" downshifts 1782972 /Source="Nicolas_upshifts" /id="D1077" /incds=0 /nref=98 /ntot=245 /MaxReadThrough="1.58009" /MaxDrop="5.56809" /score="28.8840715" /energy="-14.3" /TU="NA" /idTUdmin="U1600" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1783025..1783627) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389837.1" /db_xref="EnsemblGenomes-Gn:BSU19560" /db_xref="EnsemblGenomes-Tr:CAB13847" /db_xref="GOA:O34842" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13533" /db_xref="UniProtKB/Swiss-Prot:O34842" /translation="MKHIYEKGTSDNVLLLLHGTGGNEHDLLSLGRFIDPDAHLLGVR GSVLENGMPRFFKRLSEGVFDEKDLVVRTRELKDFIDEAAETHQFNRGRVIAVGYSNG ANIAASLLFHYKDVLKGAILHHPMVPIRGIELPDMAGLPVFIGAGKYDPLCTKEESEE LYRYLRDSGASASVYWQDGGHQLTQHEAEQAREWYKEAIV*" /label="yodD CDS" gene complement(1783025..1783627) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /label="yodD gene" CDS complement(1783643..1784554) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 17407181, 19329649, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-dependent lyase/dioxygenase" /protein_id="NP_389838.1" /db_xref="EnsemblGenomes-Gn:BSU19570" /db_xref="EnsemblGenomes-Tr:CAB13848" /db_xref="GOA:O34543" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13534" /db_xref="UniProtKB/Swiss-Prot:O34543" /translation="MKTEGLHHVTAFARDPQENLRFYTEVLGLRLVKKTVNFDDPGTY HFYFGNQNGDPGTIMTFFPFQGSGQGTVGKGQAGRVYFSVPSGSLSFWKERLEKSGLS LEEKTLFGEKGLIFDDTEDLPLAIMEDAKSGKSEWTPDGITTNEAITGMKGVLLYSYD PQATIQLLTESFGYTKVAEEDQIVRLASSAAVGGVIDVHLHPEKRGVGGYGTVHHVAF RTKKKEQAKWLPIIAENHLPSSEILDREYFTSVYFREKGGILFEIATDEPGFMTDETF AELGTSLKLPEWLEKHRQQITDILPEL*" /label="yodE CDS" gene complement(1783643..1784554) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /label="yodE gene" promotor_-10 complement(1784583..1784602) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1784599) /Source="Nicolas_upshifts" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1784618..1784623) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1784675..1784678 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1784693..1784712 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1784695 /Source="Nicolas_upshifts" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="upshifts" CDS 1784738..1784938 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016, 24843172; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="YP_003097742.1" /db_xref="EnsemblGenomes-Gn:BSU19579" /db_xref="EnsemblGenomes-Tr:CAX52639" /db_xref="GOA:C0H431" /db_xref="InterPro:IPR021741" /db_xref="UniProtKB/Swiss-Prot:C0H431" /translation="MVKKALIVILILLPFVQLALLPLVNRIEPIMFGLPFFHFWLLLW IIVTPLCSFGIYQMQKKDGGLE*" /label="yoyD CDS" gene 1784738..1784938 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /label="yoyD gene" CDS 1784938..1786428 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12823818, 15849754, 16850406, 24142252, 27766092; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite permease" /protein_id="NP_389839.1" /db_xref="EnsemblGenomes-Gn:BSU19580" /db_xref="EnsemblGenomes-Tr:CAB13849" /db_xref="GOA:O34745" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13535" /db_xref="UniProtKB/Swiss-Prot:O34745" /translation="MQGNLTALLITAIIVLTVVCIGFLAGRDKSSRTSVEEWSVGGRR FGGLLVWFLVGADLYTAYTFLGLTSTAFTGGSVAFFAIPYSVLAYFIAYFFLPKLWKV AKIHKLTTLADYARERFNSKLLASLVAIVGVLMLIPYICLQLSGIQDTLQVAGTGYIN VKFVVIISFILVALYTFFSGIKGPTYTAIIKDILVWVIMLFMVVSLPLIHFNGWTPMI DTLVKEAPQMLTIPSEGPKGIPWFITASIVSALALFMWAHAATGVFTAKSADAVRKNS MFLPLYNIVLILVIFLGFIAFLVLPEDTNPRLALLHLIQTSYGGVAQGFAYATIALAS LIPCSIMAIGASNLFANNLYRDLIHPNVSQSKLTLVTRSMVFVVIGLALLFGMLFPTA LVTLQLLGVSGMVQIFPAIAVSLFWKNQTKEATVIGLLAGLAVTFIVYITQSAHGIYE GFWGLAANMIAVVILNPLFVKNAGSNPVIEGLFGKKQDANPNQKGA*" /label="yodF CDS" gene 1784938..1786428 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /label="yodF gene" promotor_-10 complement(1785673..1785684) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1785677) /Source="Nicolas_upshifts" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1785698..1785704) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1786416 /Source="Nicolas_upshifts" /id="D1078" /incds=0 /nref=128 /ntot=189 /MaxReadThrough="1.75716" /MaxDrop="6.37839" /score="42.3111155" /energy="-14.6" /TU="NA" /idTUdmin="U1603" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1786463..1787863) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /EC_number="3.4.21.102" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8996100, 10974125, 14526016, 17114254, 19889088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxy-terminal processing protease (Prc homolog, tail specific protease)" /protein_id="NP_389840.1" /db_xref="EnsemblGenomes-Gn:BSU19590" /db_xref="EnsemblGenomes-Tr:CAB13850" /db_xref="GOA:O34666" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11794" /db_xref="UniProtKB/Swiss-Prot:O34666" /translation="MKRQLKLFFIVLITAVVASALTLFITGNSSILGQKSASTGDSKF DKLNKAYEQIKSDYYQKTDDDKLVDGAIKGMIQSLDDPYSTYMDQEQAKSFDETISAS FEGIGAQVEEKDGEILIVSPIKGSPAEKAGIKPRDQIIKVNGKSVKGMNVNEAVALIR GKKGTKVKLELNRAGVGNIDLSIKRDTIPVETVYSEMKDNNIGEIQITSFSETTAKEL TDAIDSLEKKGAKGYILDLRGNPGGLMEQAITMSNLFIDKGKNIMQVEYKNGSKEVMK AEKERKVTKPTVVLVNDGTASAAEIMAAALHESSNVPLIGETTFGKGTVQTAKEYDDG STVKLTVAKWLTADGEWIHKKGIKPQVKAELPDYAKLPYLDADKTYKSGDTGTNVKVA QKMLKALGYKVKVNSMYDQDFVSVVKQFQKKEKLNETGILTGDTTTKLMIELQKKLSD NDTQMEKAIETLKKEM*" /label="ctpA CDS" gene complement(1786463..1787863) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /label="ctpA gene" downshifts complement(1786487) /Source="Nicolas_upshifts" /id="D1079" /incds=0 /nref=188 /ntot=292 /MaxReadThrough="0.590400000000001" /MaxDrop="7.62713" /score="34.5981085" /energy="-14.6" /TU="NA" /idTUdmin="U1606" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-35 1787634..1787643 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1787655..1787670 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1787669 /Source="Nicolas_upshifts" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1787883..1787902) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1787903) /Source="Nicolas_upshifts" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1787916..1787923) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1787962..1787971 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1787977 /Source="Nicolas_upshifts" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1787984..1788003 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1788016..1788717 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19703276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_389841.1" /db_xref="EnsemblGenomes-Gn:BSU19600" /db_xref="EnsemblGenomes-Tr:CAB13851" /db_xref="GOA:O34954" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13536" /db_xref="UniProtKB/Swiss-Prot:O34954" /translation="MSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGC GTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKRFANEGLAIPAYQAELEHLPFSSESFS CVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQMMDFYGFTCL HEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQ LYSEYMGHCIFIAYK*" /label="yodH CDS" gene 1788016..1788717 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /label="yodH gene" promotor_-35 1788742..1788750 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1788764..1788783 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1788769 /Source="Nicolas_upshifts" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="upshifts" CDS 1788805..1789056 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546, 23155385; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389842.1" /db_xref="EnsemblGenomes-Gn:BSU19610" /db_xref="EnsemblGenomes-Tr:CAB13852" /db_xref="GOA:O34654" /db_xref="SubtiList:BG13537" /db_xref="UniProtKB/Swiss-Prot:O34654" /translation="MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVG GGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW*" /label="yodI CDS" gene 1788805..1789056 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /label="yodI gene" downshifts 1789077 /Source="Nicolas_upshifts" /id="D1080" /incds=0 /nref=49 /ntot=83 /MaxReadThrough="0.88268" /MaxDrop="7.18785" /score="13.9812819" /energy="-15.5" /TU="NA" /idTUdmin="U1607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1789127..1789948) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /EC_number="3.4.16.4" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8631706, 15187182, 24909784" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8631706, 15187182, 24909784; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase lipoprotein (D-ala releasing from tetrapeptide hydrolysis)" /protein_id="NP_389843.1" /db_xref="EnsemblGenomes-Gn:BSU19620" /db_xref="EnsemblGenomes-Tr:CAB13853" /db_xref="GOA:O34866" /db_xref="InterPro:IPR003709" /db_xref="InterPro:IPR009045" /db_xref="PDB:4OX3" /db_xref="SubtiList:BG13538" /db_xref="UniProtKB/Swiss-Prot:O34866" /translation="MKKSGKWFSLAAALSVTAIVGAGCSMSNGDAQKDTKTTAETKQT EQKTADSKKSNTQNSEFSLESQYFNDIKKVDGLETIQNPENILALVNKQYALPGNYEP SDLVIPDVEFSFEEKIQKRYIRKEAADALKTMFDAAKKEGYELAAVSGYRSYDRQKVI FDNEVSLKGERKAKEAVAYPGESEHQTGLAMDISSRSNGFELNEAFGSTADGKWVQDN AYKYGFIIRYPKNKEDITKYEYEPWHLRYVGKKAAKVIQDNDLTLEEYFEKVKKI*" /label="ldcB CDS" gene complement(1789127..1789948) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /label="ldcB gene" downshifts complement(1789153) /Source="Nicolas_upshifts" /id="D1081" /incds=0 /nref=180 /ntot=242 /MaxReadThrough="0.784690000000001" /MaxDrop="5.88637" /score="-9.13236272" /energy="-6.1" /TU="NA" /idTUdmin="U1609" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1789949..1790030) /Source="Nicolas_S_feature" /locus_tag="new_2135388_2135469_c" /HighExp="dia15, LBGexp, G180, LBGtran, dia0, H2O2, Oxctl, Lbexp, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S755" CDS complement(1790031..1790732) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12571059, 16511068, 21279421, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12571059, 16511068, 21279421, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_389844.1" /db_xref="EnsemblGenomes-Gn:BSU19630" /db_xref="EnsemblGenomes-Tr:CAB13854" /db_xref="GOA:O34925" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR004402" /db_xref="InterPro:IPR018016" /db_xref="InterPro:IPR035994" /db_xref="PDB:4D8V" /db_xref="PDB:4D8X" /db_xref="PDB:4D8Y" /db_xref="PDB:4D98" /db_xref="PDB:4D9H" /db_xref="PDB:4DA0" /db_xref="PDB:4DA6" /db_xref="PDB:4DA7" /db_xref="PDB:4DA8" /db_xref="PDB:4DAB" /db_xref="PDB:4DAE" /db_xref="PDB:4DAN" /db_xref="PDB:4DAO" /db_xref="PDB:4DAR" /db_xref="SubtiList:BG12581" /db_xref="UniProtKB/Swiss-Prot:O34925" /translation="MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRG MYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRD VILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFY NDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQT TFHDMIEVALHSVSQ*" /label="deoD CDS" gene complement(1790031..1790732) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /label="deoD gene" S_feature complement(1790733..1790822) /Source="Nicolas_S_feature" /locus_tag="new_2136172_2136261_c" /HighExp="dia15, G180, dia5, LBGtran, dia0, LBGexp, Lbexp, G150, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S756" promotor_-10 complement(1790807..1790826) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1790822) /Source="Nicolas_upshifts" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1790842..1790846) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1790880..1790886 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1790901..1790912 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1790918 /Source="Nicolas_upshifts" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="upshifts" CDS 1790934..1791059 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24079885" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097743.1" /db_xref="EnsemblGenomes-Gn:BSU19639" /db_xref="EnsemblGenomes-Tr:CAX52640" /db_xref="UniProtKB/Swiss-Prot:C0H432" /translation="MGKKHRNRITGQKKNNHIPEKDIIAAEEAHGKEYSAAKRKP*" /label="yoyE CDS" gene 1790934..1791059 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /label="yoyE gene" downshifts 1791057 /Source="Nicolas_upshifts" /id="D1082" /incds=0 /nref=9 /ntot=26 /MaxReadThrough="0.67198" /MaxDrop="4.89617" /score="16.4028635" /energy="-8.5" /TU="NA" /idTUdmin="U1610" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1791099..1791413) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24079885, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24079885, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="shape determination factor" /protein_id="NP_389845.2" /db_xref="EnsemblGenomes-Gn:BSU19640" /db_xref="EnsemblGenomes-Tr:CAB13855" /db_xref="InterPro:IPR025923" /db_xref="SubtiList:BG13539" /db_xref="UniProtKB/Swiss-Prot:O30472" /translation="MMLSVFKKKSCSYDVTIFQTPRFGEKKGYRAVYRTELNGSDHQD VLKRAFSLFNVFDTVPSDYDARFMATGDVILIDEGRKGKTYYQLLPAGWRKINRLIVQ TT*" /label="yodL CDS" gene complement(1791099..1791413) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /label="yodL gene" downshifts complement(1791111) /Source="Nicolas_upshifts" /id="D1083" /incds=0 /nref=96 /ntot=232 /MaxReadThrough="1.74792" /MaxDrop="5.79235" /score="-0.334745097" /energy="-8.5" /TU="NA" /idTUdmin="U1611" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1791434..1791452) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1791441) /Source="Nicolas_upshifts" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1791463..1791471) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1791474..1792085) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /EC_number="3.1.3.27" /EC_number="3.1.3.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27528508, 28168443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27528508, 28168443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol phosphate (PGP) phosphatase; undecaprenyl-pyrophosphate phosphatase (promiscuous activity)" /protein_id="NP_389846.1" /db_xref="EnsemblGenomes-Gn:BSU19650" /db_xref="EnsemblGenomes-Tr:CAB13856" /db_xref="GOA:O34349" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR036938" /db_xref="PDB:5JKI" /db_xref="SubtiList:BG13540" /db_xref="UniProtKB/Swiss-Prot:O34349" /translation="MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNE VMTGITHLGASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDRLLNKVLKEWIERV RPDFAPLVHESSFSFPSGHSMNAACVYPVIAYFLVKHLPFLSKHKKMVYIIAGVIAVL VGISRVYLGVHFVTDVLGGFSLGLLLFFLVKGFDEKIKRFRQK*" /label="pgpB CDS" gene complement(1791474..1792085) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /label="pgpB gene" CDS complement(1792163..1792339) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389847.1" /db_xref="EnsemblGenomes-Gn:BSU19660" /db_xref="EnsemblGenomes-Tr:CAB13857" /db_xref="InterPro:IPR025545" /db_xref="SubtiList:BG13751" /db_xref="UniProtKB/Swiss-Prot:O31863" /translation="MKEIDLVIDTEEIAEFFYRELARRGYIPSEDELFEIADITFDYL IEKCMIDEELDEDE*" /label="yozD CDS" gene complement(1792163..1792339) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /label="yozD gene" downshifts complement(1792167) /Source="Nicolas_upshifts" /id="D1084" /incds=0 /nref=35 /ntot=48 /MaxReadThrough="3.33111" /MaxDrop="5.99901" /score="19.8458751" /energy="-11.9" /TU="U1612,U1613" /idTUdmin="U1615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1792178) /Source="Nicolas_upshifts" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1792182..1792201) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1792217..1792220) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1792353..1792371) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-10" upshifts complement(1792374) /Source="Nicolas_upshifts" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="upshifts" S_feature complement(1792376..1792597) /Source="Nicolas_S_feature" /locus_tag="new_2137815_2138036_c" /HighExp="S8, S7, S6, BT, B36, Pyr, G/S, H2O2, S5, G135" /AntisenseName="yoyF" /AntisenseCor="0.43167183745996701" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S757" promotor_-35 complement(1792387..1792392) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-35" promotor_-35 1792397..1792402 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1792417..1792435 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1792419 /Source="Nicolas_upshifts" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="upshifts" CDS 1792458..1792601 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097744.1" /db_xref="EnsemblGenomes-Gn:BSU19669" /db_xref="EnsemblGenomes-Tr:CAX52641" /db_xref="GOA:C0H433" /db_xref="UniProtKB/Swiss-Prot:C0H433" /translation="MIAKMMEALDGERFDIIMEKTLKGMTRVMIWGCLPYFLYVLIRM FTN*" /label="yoyF CDS" gene 1792458..1792601 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /label="yoyF gene" CDS complement(1792598..1793278) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389848.1" /db_xref="EnsemblGenomes-Gn:BSU19670" /db_xref="EnsemblGenomes-Tr:CAB13858" /db_xref="SubtiList:BG13541" /db_xref="UniProtKB/Swiss-Prot:O34414" /translation="MKQNKPKFQVGDIVVVIMYGTVGTITKVHQIDKHYLYEVNHNEV LYFESSIQLYKDYEGVIVDMEKLDIEYEFLIGDVVYVKDYGKELFRIIGHRTEIWRYL EDGWEDIIYELTRLKDGEWLETEEEDLTLVLRKYEMDQFVHQLLFVHYVGETGHEIGE DIASSALLQFEGGDEDQDTLHILAVSIVDELLDIYNDYKILYEMFQDEEYKDMMMFVL ESLKEHFS*" /label="yodN CDS" gene complement(1792598..1793278) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /label="yodN gene" S_feature 1792602..1793613 /Source="Nicolas_S_feature" /locus_tag="new_2138041_2139052" /HighExp="LoTm, S3, S8, S7, S4, T5.0H, BT, T4.0H, Pyr, S6" /AntisenseName="yodN" /AntisenseCor="0.52628108909126403" /AntisenseRegPval="-19.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S758" promotor_-10 complement(1793305..1793324) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1793311) /Source="Nicolas_upshifts" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1793338..1793347) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1793429..1793653) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389849.1" /db_xref="EnsemblGenomes-Gn:BSU19680" /db_xref="EnsemblGenomes-Tr:CAB13859" /db_xref="InterPro:IPR010673" /db_xref="InterPro:IPR023089" /db_xref="InterPro:IPR036806" /db_xref="PDB:2FJ6" /db_xref="SubtiList:BG13752" /db_xref="UniProtKB/Swiss-Prot:O31864" /translation="MKSFYHYLLKYRHPKPKDSISEFANQAYEDHSFPKTSTDYHEIS SYLELNADYLHTMATFDEAWDQYESEVHGR*" /label="yozE CDS" gene complement(1793429..1793653) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /label="yozE gene" downshifts complement(1793443) /Source="Nicolas_upshifts" /id="D1085" /incds=0 /nref=115 /ntot=243 /MaxReadThrough="1.81033" /MaxDrop="7.07662" /score="34.0666929" /energy="-10.8" /TU="NA" /idTUdmin="U1616" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1793694..1793713) /Source="Nicolas_upshift_promotors" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1793706) /Source="Nicolas_upshifts" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1793740..1794018) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344, 24914178" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097745.1" /db_xref="EnsemblGenomes-Gn:BSU19689" /db_xref="EnsemblGenomes-Tr:CAX52642" /db_xref="InterPro:IPR022451" /db_xref="InterPro:IPR022453" /db_xref="UniProtKB/Swiss-Prot:C0H434" /translation="MKTCEWCGELEAVPGRNTVYWELPDGTRAIELTDTPAMVCSSCG MTYQEENTVKEIEDQLLLIQTKKLPESLTYQQLMETERILKRNYFDFS*" /label="yokU CDS" gene complement(1793740..1794018) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /label="yokU gene" CDS complement(1794015..1795430) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /EC_number="5.4.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10629195, 10839984, 11148055, 17254853, 18307109, 21538109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629195, 10839984, 11148055, 17254853, 18307109, 21538109; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="lysine 2,3-aminomutase" /protein_id="NP_389850.1" /db_xref="EnsemblGenomes-Gn:BSU19690" /db_xref="EnsemblGenomes-Tr:CAB13860" /db_xref="GOA:O34676" /db_xref="InterPro:IPR003739" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022459" /db_xref="InterPro:IPR025895" /db_xref="SubtiList:BG13542" /db_xref="UniProtKB/Swiss-Prot:O34676" /translation="MKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLK KVINLTEDEEEGVRISTKTIPLNITPYYASLMDPDNPRCPVRMQSVPLSEEMHKTKYD LEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGMGVPKKQLD AAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQ RITDHLCEILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGIND SVPIMKKLMHDLVKIRVRPYYIYQCDLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVP TFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPEPENYIPNQADAYFESV FPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLK EKKFLAQQKKQKETECGGDSS*" /label="kamA CDS" gene complement(1794015..1795430) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /label="kamA gene" promotor_-35 1794686..1794689 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1794705..1794724 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1794710 /Source="Nicolas_upshifts" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1795459..1796286) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21538109, 24914178" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epsilon-amino-beta-lysine acetyl transferase" /protein_id="NP_389851.1" /db_xref="EnsemblGenomes-Gn:BSU19700" /db_xref="EnsemblGenomes-Tr:CAB13861" /db_xref="GOA:O34895" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022525" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13543" /db_xref="UniProtKB/Swiss-Prot:O34895" /translation="MLKSIKSSGVTAVLDHDGFNKRIRVVRYDGAIEKALPDIVAAAK EENAEKIIVYAKQHDEPILAKQLFAPEGYLKGYYLGHSACVMVRYLSESRRQTDSYTE EQEIIEAIYRTAPRLRNDSTPVFTMRKAETNDMYQLSMLYKKVFRTYPTPVFDPAYIE KTMNANTVYYIMLDHDRLISAASAEINPELGHAEITDCAVLPEYRGHSLTSFLIEALE KEMAGEDIVHVFSLARASSFGMNAVLYHSGYQYGGRLINNCFIAEGLENMNIWCKQL* " /label="kamB CDS" gene complement(1795459..1796286) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /label="kamB gene" CDS complement(1796264..1797574) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /EC_number="3.5.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative deacetylase" /protein_id="NP_389852.1" /db_xref="EnsemblGenomes-Gn:BSU19710" /db_xref="EnsemblGenomes-Tr:CAB13862" /db_xref="GOA:O34984" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR033687" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12569" /db_xref="UniProtKB/Swiss-Prot:O34984" /translation="MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAV VLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNG HIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKG DVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLS AHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAW PSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWL PNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKT AHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE*" /label="yodQ CDS" gene complement(1796264..1797574) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /label="yodQ gene" CDS complement(1797583..1798236) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyloate-acetoacetate CoA-transferase" /protein_id="NP_389853.1" /db_xref="EnsemblGenomes-Gn:BSU19720" /db_xref="EnsemblGenomes-Tr:CAB13863" /db_xref="GOA:O34466" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="SubtiList:BG13544" /db_xref="UniProtKB/Swiss-Prot:O34466" /translation="MGLGVAEREQIAKRAATEIKQGMIVNLGIGIPSLVPNFLKPDMQ VMFQAENGVLGIGESPEKGEEDAHLCNAAGYPVRAVKGASYFDTTMSFAMIRKGKIDI TILGALQVSQSGDLANWLVPGKKVPGMGGAMELAQKAKKVVVVMSHTDQKGRPKLTER CTLPLTAAGCVDLIITEKAVLEVDSHHFILKELMNGSTIDEVTRLTEAEIKIDMPFS* " /label="yodR CDS" gene complement(1797583..1798236) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /label="yodR gene" CDS complement(1798221..1798910) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxoacid CoA-transferase" /protein_id="NP_389854.1" /db_xref="EnsemblGenomes-Gn:BSU19730" /db_xref="EnsemblGenomes-Tr:CAB13864" /db_xref="GOA:O34317" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="SubtiList:BG13545" /db_xref="UniProtKB/Swiss-Prot:O34317" /translation="MAPFQKAISIDTAIADVRDGSVLMFGGFGGVGSPPSLIEAILDS GVTDLTVICNDAGFPDIGIGPLIVNQRVKTLIASHIGSNPVAGKQMTEGTLEVQFSPQ GTLAERIRAGGAGLGGILTDVGIDNQMVCEKKDIVTVAGKRYLIEEALTADFAFINAY IADEFGNLTYDKTARNMNPLMAMAARRTFAEAERIVPMGEISEEMIVTPGVFVEGVVR SEGVKWKWAWE*" /label="yodS CDS" gene complement(1798221..1798910) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /label="yodS gene" CDS complement(1798917..1800251) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /EC_number="2.6.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10839984, 15150230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminovalerate aminotransferase" /protein_id="NP_389855.1" /db_xref="EnsemblGenomes-Gn:BSU19740" /db_xref="EnsemblGenomes-Tr:CAB13865" /db_xref="GOA:O34662" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13546" /db_xref="UniProtKB/Swiss-Prot:O34662" /translation="MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCN IGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSE AIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERY PAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPP PGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAP IAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGA VLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRG LIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD*" /label="yodT CDS" gene complement(1798917..1800251) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /label="yodT gene" CDS complement(1800232..1800387) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513966.1" /translation="MLDAEISKEPSLLGRLFLCEKVFAGNVMPPFGHSYNMVKGVLRW EHEQLFD*" /label="conserved hypothetical protein CDS" gene complement(1800232..1800387) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /label="gene" promotor_-10 complement(1800270..1800288) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1800286) /Source="Nicolas_upshifts" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1800304..1800309) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1800381..1800614) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a type I toxin family (sporulation operon)" /protein_id="YP_003097746.2" /db_xref="EnsemblGenomes-Gn:BSU19749" /db_xref="EnsemblGenomes-Tr:CAX52643" /db_xref="GOA:C0H435" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H435" /translation="MSGCILYFIISLHEIGVCTNHLGLGPHKMSYIVIRKDENSMYGY SGYGYGFGCGTNTFVLIVVLFILLIIVGAAFIC*" /label="yoyG CDS" gene complement(1800381..1800614) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /label="yoyG gene" downshifts complement(1800388) /Source="Nicolas_upshifts" /id="D1086" /incds=0 /nref=96 /ntot=237 /MaxReadThrough="2.70127" /MaxDrop="7.98506" /score="25.3834194" /energy="-16.5" /TU="NA" /idTUdmin="U1620" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 1800490..1800494 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1800503..1800517 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1800518 /Source="Nicolas_upshifts" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1800519..1800538) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1800528) /Source="Nicolas_upshifts" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1800553..1800562) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1800574..1801353) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 7592393, 10066829, 27260256" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 7592393, 10066829, 27260256; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389856.1" /db_xref="EnsemblGenomes-Gn:BSU19750" /db_xref="EnsemblGenomes-Tr:CAB13866" /db_xref="GOA:P42093" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11197" /db_xref="UniProtKB/Swiss-Prot:P42093" /translation="MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQL HDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDM KLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADII ILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAK SLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT*" /label="cgeE CDS" gene complement(1800574..1801353) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /label="cgeE gene" CDS complement(1801382..1802662) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in maturation of the outermost layer of the spore" /protein_id="NP_389857.1" /db_xref="EnsemblGenomes-Gn:BSU19760" /db_xref="EnsemblGenomes-Tr:CAB13867" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11196" /db_xref="UniProtKB/Swiss-Prot:P42092" /translation="MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNA ETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVY HPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHC SVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTP DSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYL FQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKE EMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQK PISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE*" /label="cgeD CDS" gene complement(1801382..1802662) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /label="cgeD gene" promotor_-10 complement(1802030..1802048) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1802046) /Source="Nicolas_upshifts" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1802062..1802069) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1802630..1802648) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1802640) /Source="Nicolas_upshifts" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1802664..1802669) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1802727..1803032) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389858.1" /db_xref="EnsemblGenomes-Gn:BSU19770" /db_xref="EnsemblGenomes-Tr:CAB13868" /db_xref="SubtiList:BG11195" /db_xref="UniProtKB/Swiss-Prot:P42091" /translation="MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLV FAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF* " /label="cgeC CDS" gene complement(1802727..1803032) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /label="cgeC gene" downshifts complement(1802860) /Source="Nicolas_upshifts" /id="D1087" /incds=1 /nref=2 /ntot=28 /MaxReadThrough="5.32389" /MaxDrop="2.61092" /score="23.1569137" /energy="-13.4" /TU="U1623" /idTUdmin="U1623" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1803056..1803075) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-10" upshifts complement(1803071) /Source="Nicolas_upshifts" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="upshifts" promotor_-35 complement(1803089..1803098) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-35" promotor_-35 1803168..1803177 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1803191..1803210 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1803191 /Source="Nicolas_upshifts" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1803212) /Source="Nicolas_upshifts" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1803214..1803228) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1803237..1803241) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1803237..1803638 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:759239, 14702409, 15621419, 19933362, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 759239, 14702409, 15621419, 19933362, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outermost layer component" /protein_id="NP_389859.1" /db_xref="EnsemblGenomes-Gn:BSU19780" /db_xref="EnsemblGenomes-Tr:CAB13869" /db_xref="SubtiList:BG11193" /db_xref="UniProtKB/Swiss-Prot:P42089" /translation="MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAID QKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGI VFVTQESSVTPAGQATTLIDVDKVESVTFFS*" /label="cgeA CDS" gene 1803237..1803638 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /label="cgeA gene" CDS 1803645..1804598 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389860.2" /db_xref="EnsemblGenomes-Gn:BSU19790" /db_xref="EnsemblGenomes-Tr:CAB13870" /db_xref="InterPro:IPR024542" /db_xref="SubtiList:BG11194" /db_xref="UniProtKB/Swiss-Prot:P42090" /translation="MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLM KIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAIL TIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMK EAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRP YHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAA FYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS*" /label="cgeB CDS" gene 1803645..1804598 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /label="cgeB gene" downshifts 1804588 /Source="Nicolas_upshifts" /id="D1088" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="2.94229" /MaxDrop="5.87549" /score="22.1420541" /energy="-9" /TU="NA" /idTUdmin="U1624" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1804669..1805817) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /EC_number="3.1.3.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phytase" /protein_id="NP_389861.1" /db_xref="EnsemblGenomes-Gn:BSU19800" /db_xref="EnsemblGenomes-Tr:CAB13871" /db_xref="GOA:P42094" /db_xref="InterPro:IPR003431" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11198" /db_xref="UniProtKB/Swiss-Prot:P42094" /translation="MKVPKTMLLSTAAGLLLSLTATSVSAHYVNEEHHFKVTAHTETD PVASGDDAADDPAIWVHEKHPEKSKLITTNKKSGLVVYDLDGKQLHSYEFGKLNNVDL RYDFPLNGEKIDIAAASNRSEGKNTIEVYAIDGDKGKLKSITDPNHPISTNISEVYGF SLYHSQKTGAFYALVTGKQGEFEQYEIVDGGKGYVTGKKVREFKLNSQTEGLVADDEY GNLYIAEEDEAIWKFNAEPGGGSKGQVVDRATGDHLTADIEGLTIYYAPNGKGYLMAS SQGNNSYAMYERQGKNRYVANFEITDGEKIDGTSDTDGIDVLGFGLGPKYPYGIFVAQ DGENIDNGQAVNQNFKIVSWEQIAQHLGEMPDLHKQVNPRKLKDRSDG*" /label="phyC CDS" gene complement(1804669..1805817) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /label="phyC gene" downshifts complement(1804686) /Source="Nicolas_upshifts" /id="D1089" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="2.64059" /MaxDrop="5.59857" /score="17.7154517" /energy="-8.7" /TU="NA" /idTUdmin="U1629" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" promotor_-35 1805830..1805834 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1805843..1805862) /Source="Nicolas_upshift_promotors" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1805850..1805869 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1805852) /Source="Nicolas_upshifts" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 1805860 /Source="Nicolas_upshifts" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1806121..1806129 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1806143..1806162 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1806146 /Source="Nicolas_upshifts" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="upshifts" CDS 1806187..1807212 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014664318.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein" /protein_id="WP_003230816.1" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /translation="MPKQQTAELKPFFHNKTVLVTGGTGSIGSQIVKRLLMLTPKQVI VFSKDDSKQYVMSQKYAEDKRLLFVLGDVRDHRRVNQVMKGVDIVFHAAALKQVPTCE DHPFEAIQTNLIGGQNVVEAALSHRVQHVINISTDKAVSPVNTMGATKLLSEKLFHQA NRHVQNKGTLFCSVRFGNVLGSRGSVIPILFEQMMEGEPLTITDKNMTRFFMSIDDAA TLTLQSAAITKGGETFIFKMESLKLEELIHGFEEYASQHGLPRPAAVEVGKRPGEKLH EELTSPHEIESLYEWGNLYAILPEPEKHPDFRKVNLPGYQSDQAPLITKERIAQIIEE LHQEKKA*" /label="Delta6_BSU_19810-BSU_21670" gene 1806187..1807212 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /label="Delta6_BSU_19810-BSU_21670" downshifts 1806590 /Source="Nicolas_upshifts" /id="D1090" /incds=0 /nref=18 /ntot=39 /MaxReadThrough="0.75679" /MaxDrop="7.79081" /score="-6.65536786" /energy="-8.7" /TU="NA" /idTUdmin="U1628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 <1806592..1806596 /Source="Nicolas_upshift_promotors" /id="U1702" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1418 /SigmaFactorBS="tttcatttttgacctcacagccactaATAGTTTCCActaaga aaagtagTAAGTATCTTAAAAAACAGAtaaagctgtatctcctgtgaacacaatgggt g" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" SCAR 1806606..1806607 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta_SP_beta" downshifts 1807204 /Source="Nicolas_upshifts" /id="D1134" /incds=0 /nref=22 /ntot=177 /MaxReadThrough="2.90949" /MaxDrop="5.54327" /score="-2.31796312" /energy="-13.5" /TU="NA" /idTUdmin="U1701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1807256..1807687) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /EC_number="1.8.4.12" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15680230, 16803968, 17031545, 18239417, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine R-sulfoxide reductase" /protein_id="NP_390051.1" /db_xref="EnsemblGenomes-Gn:BSU21680" /db_xref="EnsemblGenomes-Tr:CAB14086" /db_xref="GOA:P54155" /db_xref="InterPro:IPR002579" /db_xref="InterPro:IPR011057" /db_xref="InterPro:IPR028427" /db_xref="PDB:2KZN" /db_xref="PDB:3E0O" /db_xref="SubtiList:BG11628" /db_xref="UniProtKB/Swiss-Prot:P54155" /translation="MAYNKEEKIKSLNRMQYEVTQNNGTEPPFQNEYWDHKEEGLYVD IVSGKPLFTSKDKFDSQCGWPSFTKPIEEEVEEKLDTSHGMIRTEVRSRTADSHLGHV FNDGPGPNGLRYCINSAALRFVPKHKLKEEGYESYLHLFNK*" /label="msrB CDS" gene complement(1807256..1807687) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /label="msrB gene" downshifts complement(1807261) /Source="Nicolas_upshifts" /id="D1135" /incds=0 /nref=229 /ntot=262 /MaxReadThrough="2.46559" /MaxDrop="6.77483" /score="1.42817565" /energy="-12.3" /TU="NA" /idTUdmin="U1704" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1807688..1808221) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /EC_number="1.8.4.11" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9573155, 16803968, 17062561, 18662407" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573155, 16803968, 17062561, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine S-sulfoxide reductase" /protein_id="NP_390052.1" /db_xref="EnsemblGenomes-Gn:BSU21690" /db_xref="EnsemblGenomes-Tr:CAB14087" /db_xref="GOA:P54154" /db_xref="InterPro:IPR002569" /db_xref="InterPro:IPR036509" /db_xref="SubtiList:BG11627" /db_xref="UniProtKB/Swiss-Prot:P54154" /translation="MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPT YEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIF YHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY RTGSGRAGFISEHWGAK*" /label="msrA CDS" gene complement(1807688..1808221) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /label="msrA gene" promotor_-35 1808225..1808231 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1808242..1808352 /Source="Nicolas_S_feature" /locus_tag="new_2288083_2288193" /HighExp="B60, Lbstat, Cold, M9-stat, T4.0H, LoTm, S0, T3.30H, BC, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S817" upshifts 1808242 /Source="Nicolas_upshifts" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1808244..1808263 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1808249..1808268) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1808269) /Source="Nicolas_upshifts" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1808284..1808285) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1808353..1808778 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9571784, 10809700; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_390053.1" /db_xref="EnsemblGenomes-Gn:BSU21700" /db_xref="EnsemblGenomes-Tr:CAB14088" /db_xref="GOA:P54182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11626" /db_xref="UniProtKB/Swiss-Prot:P54182" /translation="MKVRTQMMYDMETLLRKVFKQIRNEINEILDKELSRNEFTILRI LSEQGPKKVTEFAPILEVSASHITAVTDALVEKEWITRIRSKEDRRIIRIHITEAGEK VLQHFNEKKTEYFFKRFDCYTDAELATLIELFSKLDKKR*" /label="ypoP CDS" gene 1808353..1808778 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /label="ypoP gene" downshifts 1808766 /Source="Nicolas_upshifts" /id="D1136" /incds=0 /nref=92 /ntot=248 /MaxReadThrough="4.04021" /MaxDrop="5.35086" /score="-1.90494373" /energy="-7" /TU="U1703" /idTUdmin="U1703" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 1808811..1810042 /Source="Nicolas_S_feature" /locus_tag="new_2288652_2289883" /HighExp="Cold, ferm, nit, C30, S0, Lbstat, T3.30H, T-4.40H, T5.0H, G135" /AntisenseName="dinF" /AntisenseCor="0.270994122332881" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S818" CDS complement(1808828..1810165) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11583854, 15849754, 16850406, 22933559, 26246409; Product type t : transporter" /codon_start=1 /transl_table=11 /product="damage inducible, Na+ driven multidrug efflux pump" /protein_id="NP_390054.1" /db_xref="EnsemblGenomes-Gn:BSU21710" /db_xref="EnsemblGenomes-Tr:CAB14089" /db_xref="GOA:P54181" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG11625" /db_xref="UniProtKB/Swiss-Prot:P54181" /translation="MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLL GAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTG LSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALG DSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKL VPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQR LDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFG KYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISF WVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK*" /label="dinF CDS" gene complement(1808828..1810165) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /label="dinF gene" CDS complement(1810237..1810431) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390055.1" /db_xref="EnsemblGenomes-Gn:BSU21720" /db_xref="EnsemblGenomes-Tr:CAB14090" /db_xref="GOA:P54180" /db_xref="InterPro:IPR035403" /db_xref="SubtiList:BG11624" /db_xref="UniProtKB/Swiss-Prot:P54180" /translation="MKRIYQYFSLLSFTFSLYFGWLAYHHLAAEDMDQMYLNVSYCAL FLSVMVFTFGMRDRKKTDKS*" /label="ypmT CDS" gene complement(1810237..1810431) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /label="ypmT gene" downshifts complement(1810250) /Source="Nicolas_upshifts" /id="D1137" /incds=0 /nref=123 /ntot=248 /MaxReadThrough="3.84998" /MaxDrop="4.80224" /score="-2.26655222" /energy="-15.5" /TU="U1705" /idTUdmin="U1707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1810444..1811007) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390056.1" /db_xref="EnsemblGenomes-Gn:BSU21730" /db_xref="EnsemblGenomes-Tr:CAB14091" /db_xref="GOA:P54179" /db_xref="InterPro:IPR018672" /db_xref="SubtiList:BG11623" /db_xref="UniProtKB/Swiss-Prot:P54179" /translation="MNKWKRLFFILLAINFILAAGFVALVLLPGEQAQVKDASESEYG FQVTSTKESLAAFVNSYLNDKASNKLDYKVEIDDDVHVAGKIKAFSTSIDAFIAFEPT VKKNGDVELNVTKFSLGKLSIPISFVLNYMDSFYELPSFVHVHPGDKSIEVRLSEMPL TNGMYVKADKINLEKDEIEFSYYHPKQ*" /label="ypmS CDS" gene complement(1810444..1811007) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /label="ypmS gene" CDS complement(1811017..1811784) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17220230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported lipase/acylhydrolase (lipoprotein)" /protein_id="NP_390057.1" /db_xref="EnsemblGenomes-Gn:BSU21740" /db_xref="EnsemblGenomes-Tr:CAB14092" /db_xref="GOA:P40766" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11022" /db_xref="UniProtKB/Swiss-Prot:P40766" /translation="MKLRIFSIMASLILLLTACTSIRTSSEGKQKAHETKTKEHIVIA AVGDSLTEGVGDPDGKGYVGKVADSIRSDKQVKTVDVKNYAVKGNRSDDLLEKLKDKK VQKGIKDADYVFFTIGGNDLMKILRQNFLQLTVEPFQEAEKPYEKRFEKIISEIRELN DHAELIYVSMYNPFTFTLSELNEINGVVTDWNHIAEKELKKDKHAKIVHIEDLFNQKS DSSRISEEDDFHPNGTGYSLIAKRVYQAIKKEGLPKE*" /label="ypmR CDS" gene complement(1811017..1811784) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /label="ypmR gene" promotor_-10 complement(1811808..1811827) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1811825) /Source="Nicolas_upshifts" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1811838..1811845) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1811862..1812443) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10837475, 14680962, 14766920, 16305244, 19027886, 29131589" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10837475, 14680962, 14766920, 16305244, 19027886, 29131589; Product type f : factor" /codon_start=1 /transl_table=11 /product="assembly factor BSco of the Cu(A) site of cytochrome c oxidase" /protein_id="NP_390058.2" /db_xref="EnsemblGenomes-Gn:BSU21750" /db_xref="EnsemblGenomes-Tr:CAB14093" /db_xref="GOA:P54178" /db_xref="InterPro:IPR003782" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ON4" /db_xref="PDB:1XZO" /db_xref="SubtiList:BG11622" /db_xref="UniProtKB/Swiss-Prot:P54178" /translation="MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKN VSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDK PKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYL VGPDGKVLKDYNGVENTPYDDIISDVKSASTLK*" /label="scuA CDS" gene complement(1811862..1812443) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /label="scuA gene" S_feature complement(1812444..1812559) /Source="Nicolas_S_feature" /locus_tag="new_2292285_2292400_c" /HighExp="T5.0H, T3.30H, S2, T3.0H, BC, T2.30H, T4.0H, S1, HiOs, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S819" CDS complement(1812591..1812842) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15060025, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390059.1" /db_xref="EnsemblGenomes-Gn:BSU21760" /db_xref="EnsemblGenomes-Tr:CAB14094" /db_xref="InterPro:IPR019687" /db_xref="SubtiList:BG11621" /db_xref="UniProtKB/Swiss-Prot:P54177" /translation="MLLKSLEFKRGDGIQVKVTEIPVLKEDEHYFFMLHHHLQFYLKE VFSSNSRAKVYSFRHYMKRRMKWADYQAVFHQEVLKHNA*" /label="ypmP CDS" gene complement(1812591..1812842) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /label="ypmP gene" downshifts complement(1812604) /Source="Nicolas_upshifts" /id="D1138" /incds=0 /nref=2 /ntot=117 /MaxReadThrough="4.5803" /MaxDrop="2.91481" /score="26.0320926" /energy="-21.8" /TU="U1707" /idTUdmin="U1706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1812865..1812884) /Source="Nicolas_upshift_promotors" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1812879) /Source="Nicolas_upshifts" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1812928..1814196) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /EC_number="4.3.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine dehydratase" /protein_id="NP_390060.1" /db_xref="EnsemblGenomes-Gn:BSU21770" /db_xref="EnsemblGenomes-Tr:CAB14095" /db_xref="GOA:P37946" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001721" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011820" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10673" /db_xref="UniProtKB/Swiss-Prot:P37946" /translation="MKPLLKENSLIQVKDILKAHQNVKDVVIHTPLQRNDRLSERYEC NIYLKREDLQVVRSFKLRGAYHKMKQLSSEQTENGVVCASAGNHAQGVAFSCKHLGIH GKIFMPSTTPRQKVSQVELFGKGFIDIILTGDTFDDAYKSAAECCEAESRTFIHPFDD PDVMAGQGTLAVEILNDIDTEPHFLFASVGGGGLLSGVGTYLKNVSPDTKVIAVEPAG AASYFESNKAGHVVTLDKIDKFVDGAAVKKIGEETFRTLETVVDDILLVPEGKVCTSI LELYNECAVVAEPAGALSVAALDLYKDQIKGKNVVCVVSGGNNDIGRMQEMKERSLIF EGLQHYFIVNFPQRAGALREFLDEVLGPNDDITRFEYTKKNNKSNGPALVGIELQNKA DYGPLIERMNKKPFHYVEVNKDEDLFHLLI*" /label="ilvA CDS" gene complement(1812928..1814196) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /label="ilvA gene" promotor_-10 complement(1814230..1814249) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1814249) /Source="Nicolas_upshifts" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1814261..1814268) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1814403..1814422 /Source="Nicolas_upshift_promotors" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1814406 /Source="Nicolas_upshifts" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="upshifts" CDS 1814445..1815440 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12399512, 16585774, 19763274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399512, 16585774, 19763274; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional enhancer involved in BCAA homeostasis" /protein_id="NP_390061.1" /db_xref="EnsemblGenomes-Gn:BSU21780" /db_xref="EnsemblGenomes-Tr:CAB14096" /db_xref="GOA:P54156" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013668" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11619" /db_xref="UniProtKB/Swiss-Prot:P54156" /translation="MNSAPKLNTFQHLIGEHQTFLEAKRIAKQFSLSELPVLITGKIG TGKNHFAHAIHLESSRSNEPFISVNCSTHSEETLIHELFGPNGNTGVFQKAVRGTLFL DDVWRMPASVQAQLLKALDSDTEKPRMICASADRSVEHTFRQDLFYRLNILTLTLPEL SERKSDIPLLTQHFLSNSGQQLLIDPSVFPVLEKHAFEGNVRELKNAADYMAAVSSGG TIQPYDLPPYIRGTIDGKTSKKKAKLLTLMEKAEFLFILETIKVLNEKGEPASRRIIS EHSKNTQTSLTPQQVRSRLDYLEKKDYVTKSRGRAGTKITFEGLSFIETLKNQMI*" /label="silP CDS" gene 1814445..1815440 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /label="silP gene" CDS 1815461..1816102 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16585774, 16850406, 19763274; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_390062.1" /db_xref="EnsemblGenomes-Gn:BSU21790" /db_xref="EnsemblGenomes-Tr:CAB14097" /db_xref="GOA:P54175" /db_xref="InterPro:IPR004254" /db_xref="InterPro:IPR005744" /db_xref="SubtiList:BG11620" /db_xref="UniProtKB/Swiss-Prot:P54175" /translation="MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSF TIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLG FTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSL LFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS*" /label="yplQ CDS" gene 1815461..1816102 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /label="yplQ gene" S_feature 1816103..1817204 /Source="Nicolas_S_feature" /locus_tag="new_2295944_2297045" /HighExp="Cold, C30, Sw, BC, G135, LoTm, Fru, C90, BI, S0" /AntisenseName="ypkP" /AntisenseCor="0.28434605181220002" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S820" CDS complement(1816141..1816761) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 1-acyl-sn-glycerol-3-phosphate acyltransferase" /protein_id="NP_390063.2" /db_xref="EnsemblGenomes-Gn:BSU21800" /db_xref="EnsemblGenomes-Tr:CAB14098" /db_xref="SubtiList:BG11618" /db_xref="UniProtKB/Swiss-Prot:P54174" /translation="MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQ PKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANP KVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYH LPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA*" /label="ypkP CDS" gene complement(1816141..1816761) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /label="ypkP gene" downshifts complement(1816167) /Source="Nicolas_upshifts" /id="D1139" /incds=0 /nref=72 /ntot=241 /MaxReadThrough="1.32187" /MaxDrop="5.02823" /score="16.0584527" /energy="-13.4" /TU="NA" /idTUdmin="U1710" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1816762..1817268) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /EC_number="1.5.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2840350, 3918568, 10574451, 12682299, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2840350, 3918568, 10574451, 12682299, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydrofolate reductase" /protein_id="NP_390064.1" /db_xref="EnsemblGenomes-Gn:BSU21810" /db_xref="EnsemblGenomes-Tr:CAB14099" /db_xref="GOA:P11045" /db_xref="InterPro:IPR001796" /db_xref="InterPro:IPR012259" /db_xref="InterPro:IPR017925" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG10795" /db_xref="UniProtKB/Swiss-Prot:P11045" /translation="MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGR KTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYT DLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK NSSKAGGF*" /label="dfrA CDS" gene complement(1816762..1817268) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /label="dfrA gene" CDS complement(1817265..1818059) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9648749, 10574451, 19732150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9648749, 10574451, 19732150; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase B" /protein_id="NP_390065.1" /db_xref="EnsemblGenomes-Gn:BSU21820" /db_xref="EnsemblGenomes-Tr:CAB14100" /db_xref="GOA:P11044" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="SubtiList:BG10794" /db_xref="UniProtKB/Swiss-Prot:P11044" /translation="MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPM LTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWR GADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNL QLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV*" /label="thyB CDS" gene complement(1817265..1818059) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /label="thyB gene" CDS complement(1818143..1818676) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8534098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_390066.1" /db_xref="EnsemblGenomes-Gn:BSU21830" /db_xref="EnsemblGenomes-Tr:CAB14101" /db_xref="GOA:P54173" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="PDB:1TLQ" /db_xref="SubtiList:BG11617" /db_xref="UniProtKB/Swiss-Prot:P54173" /translation="MKKYTMNEMVDITKDMLNKRGVMIEDIARIVQKLQEKYNPNLPL SVCMENVEKVLNKREIIHAVLTGLALDQLAEQKLLPEPLQHLVETDEPLYGIDEIIPL SIVNVYGSIGLTNFGYLDKEKIGIIKELDESPDGIHTFLDDIVAALAAAAASRIAHTH QDLQDEEKEQDEKPVVS*" /label="ypjQ CDS" gene complement(1818143..1818676) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /label="ypjQ gene" downshifts complement(1818148) /Source="Nicolas_upshifts" /id="D1140" /incds=0 /nref=17 /ntot=167 /MaxReadThrough="4.91561" /MaxDrop="4.18561" /score="15.5758445" /energy="-9.3" /TU="U1710" /idTUdmin="U1711" /TUdmin=1232 /isTUend="FALSE" /label="downshifts" promotor_-35 1818606..1818611 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1818622..1819568 /Source="Nicolas_S_feature" /locus_tag="new_2298463_2299409" /HighExp="S5, S6, S4, S8, S7, S3, B36, BT, B60, T5.0H" /AntisenseName="ypjP" /AntisenseCor="-0.72590712604537599" /AntisenseRegPval="-44.6" /CDS_PredictionProba="0.99932399999999999" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S821" upshifts 1818624 /Source="Nicolas_upshifts" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1818628..1818646 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1818694..1819305) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390067.1" /db_xref="EnsemblGenomes-Gn:BSU21840" /db_xref="EnsemblGenomes-Tr:CAB14102" /db_xref="GOA:P54172" /db_xref="InterPro:IPR025616" /db_xref="SubtiList:BG11616" /db_xref="UniProtKB/Swiss-Prot:P54172" /translation="MKLWMRKTLVVLFTIVTFGLVSPPAALMADKPSGQPSSLEQNDY TAFYDEHDLYDDESDDRRDPELLFQSYKEQLLDSAEDQSFLKFGSRIAPVIEDDYRKE ILPKIENVISDYLATLQDDEAYQDVVISSMPSAGKTEKIFNVYNRTTGEDLLRFHVRR DHPPHDGYWFNFHYHTAEDGFQSHHELGSIYWDRNTPPNWMSA*" /label="ypjP CDS" gene complement(1818694..1819305) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /label="ypjP gene" promotor_-10 complement(1819337..1819356) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1819356) /Source="Nicolas_upshifts" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1819369..1819374) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1819525 /Source="Nicolas_upshifts" /id="D1141" /incds=0 /nref=57 /ntot=234 /MaxReadThrough="3.131" /MaxDrop="5.18613" /score="2.81720493" /energy="-15" /TU="U1709" /idTUdmin="U1709" /TUdmin="-527" /isTUend="FALSE" /label="downshifts" CDS complement(1819565..1820338) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /EC_number="2.1.1.242" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22079366; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 16S rRNA m(2)G1516 methyltransferase" /protein_id="NP_390068.2" /db_xref="EnsemblGenomes-Gn:BSU21850" /db_xref="EnsemblGenomes-Tr:CAB14103" /db_xref="GOA:P54171" /db_xref="InterPro:IPR007536" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11615" /db_xref="UniProtKB/Swiss-Prot:P54171" /translation="MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAER DLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCT LGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKN GDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVA RKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP*" /label="rsmJ CDS" gene complement(1819565..1820338) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /label="rsmJ gene" downshifts complement(1819600) /Source="Nicolas_upshifts" /id="D1142" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="2.86923" /MaxDrop="2.91228" /score="9.10717118" /energy="-15" /TU="U1711" /idTUdmin="U1711" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(1820380..1820814) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19653655, 21749987, 22938038, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19653655, 21749987, 22938038, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein disulfide isomerase; bacilliredoxin A (de-bacillithiolation)" /protein_id="NP_390069.1" /db_xref="EnsemblGenomes-Gn:BSU21860" /db_xref="EnsemblGenomes-Tr:CAB14104" /db_xref="InterPro:IPR009474" /db_xref="PDB:3FHK" /db_xref="SubtiList:BG11614" /db_xref="UniProtKB/Swiss-Prot:P54170" /translation="MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGT TLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEP SSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC*" /label="brxA CDS" gene complement(1820380..1820814) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /label="brxA gene" downshifts complement(1820392) /Source="Nicolas_upshifts" /id="D1143" /incds=0 /nref=9 /ntot=210 /MaxReadThrough="5.2935" /MaxDrop="3.1992" /score="21.0933404" /energy="-9.7" /TU="U1711,U1712" /idTUdmin="U1712" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1820843..1820862) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-10" upshifts complement(1820854) /Source="Nicolas_upshifts" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="upshifts" S_feature complement(1820856..1820920) /Source="Nicolas_S_feature" /locus_tag="new_2300697_2300761_c" /HighExp="Sw, S1, BC, Gly, HiOs, HiTm, GM-0.1, UNK1, Fru, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S822" promotor_-35 complement(1820876..1820883) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-35" downshifts complement(1820899) /Source="Nicolas_upshifts" /id="D1144" /incds=0 /nref=32 /ntot=128 /MaxReadThrough="5.73826" /MaxDrop="4.95094" /score="26.9702838" /energy="-25.8" /TU="U1712" /idTUdmin="U1713" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1820921..1822597) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /EC_number="4.2.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12193635, 12618455, 15060025, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193635, 12618455, 15060025, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxy-acid dehydratase" /protein_id="NP_390070.2" /db_xref="EnsemblGenomes-Gn:BSU21870" /db_xref="EnsemblGenomes-Tr:CAB14105" /db_xref="GOA:P51785" /db_xref="InterPro:IPR000581" /db_xref="InterPro:IPR004404" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR020558" /db_xref="SubtiList:BG11532" /db_xref="UniProtKB/Swiss-Prot:P51785" /translation="MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYI DIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIAD SVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS LSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGN GTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVL HTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKK EGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAII KTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLA PTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIE KRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI*" /label="ilvD CDS" gene complement(1820921..1822597) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /label="ilvD gene" S_feature complement(1822598..1822788) /Source="Nicolas_S_feature" /locus_tag="new_2302439_2302629_c" /HighExp="S1, T-5.40H, MG 45, HiOs, T-4.40H, MG 120, UNK1, MG 25, MG-0.2, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.97" /TUlongSig="SigH" /TUlongPSig=1 /label="S823" promotor_-10 complement(1822777..1822796) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1822788) /Source="Nicolas_upshifts" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1822811..1822814) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1822886..1824019) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase or scaffold" /protein_id="NP_390071.1" /db_xref="EnsemblGenomes-Gn:BSU21880" /db_xref="EnsemblGenomes-Tr:CAB14106" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR014824" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR025989" /db_xref="InterPro:IPR036498" /db_xref="SubtiList:BG11613" /db_xref="UniProtKB/Swiss-Prot:P54169" /translation="MKIKSIEPTPSPNTMKVILTEELPAGKSNNYKPEQAEGAPLVIA EILKIDGVKGVYHVADFLAVERNARYDWKDILPQVRTAFGMESAESAEENRSDQESFG EVKVFVQMFSGIPMQVKLTDGEREERFGLPERFQQAILKLRSEASNVVFERAWKEQGV RFGDFDEIGHDVTEELQAAYSDERLKRLTEAAAQGKGEAKQAVQRKAYKVTLDMLDDE DWKKRYAHLEQMDPKEEDIPVLQKALDDPKVSIRRQAVVYLGMIETPDVLPLLYKALE DKAVSVRRTAGDCLSDIGDPQAIPAMIKSLSDSSKLVRWRAAMFLYEVGDESAIEALR AAEDDPEFEVSLQVKMALERIEHGEEAKGSVWKQMTESRKKGE*" /label="ypgR CDS" gene complement(1822886..1824019) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /label="ypgR gene" downshifts complement(1822902) /Source="Nicolas_upshifts" /id="D1145" /incds=0 /nref=193 /ntot=249 /MaxReadThrough="5.33526" /MaxDrop="6.88149" /score="18.2078317" /energy="-8.7" /TU="U1713" /idTUdmin="U1714" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature complement(1824041..1824060) /Source="Nicolas_upshift_promotors" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1824044) /Source="Nicolas_upshifts" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1824079..1824696) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /EC_number="3.6.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25005104, 27062940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25005104, 27062940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Mn(2+)-dependent (deoxy)ribonucleoside pyrophosphohydrolase" /protein_id="NP_390072.1" /db_xref="EnsemblGenomes-Gn:BSU21890" /db_xref="EnsemblGenomes-Tr:CAB14107" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11612" /db_xref="UniProtKB/Swiss-Prot:P54168" /translation="MKELKQAEQIRTWVQSILTDESSGHDWHHVSRVADLAAYIGEKE KADLFIVETAALVHDLIDVKLPDTVRLSVSEVYDQLVFFGVGKENADRVIHIITRMSF RDRGKLAKEPLSIEGKAVQDADRLDAIGAVGIARAFMFAGAKGHGLYGDEQSAYAHFF HKLLRLKDMMNTDTARELAEERHNFMLQFVRQLEKDIPGIDAETS*" /label="hdhQ CDS" gene complement(1824079..1824696) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /label="hdhQ gene" CDS complement(1824712..1825194) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /EC_number="1.11.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14563871, 14617062, 21749987, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol peroxidase" /protein_id="NP_390073.1" /db_xref="EnsemblGenomes-Gn:BSU21900" /db_xref="EnsemblGenomes-Tr:CAB14108" /db_xref="GOA:P52035" /db_xref="InterPro:IPR000889" /db_xref="InterPro:IPR029759" /db_xref="InterPro:IPR029760" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11530" /db_xref="UniProtKB/Swiss-Prot:P52035" /translation="MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQL QELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNA HPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ *" /label="bsaA CDS" gene complement(1824712..1825194) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /label="bsaA gene" S_feature complement(1825195..1825342) /Source="Nicolas_S_feature" /locus_tag="new_2305036_2305183_c" /HighExp="S2, HiOs, S1, Etha, T2.30H, T3.0H, Lbtran, M0t90, T2.0H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S824" promotor_-10 complement(1825333..1825351) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-10" upshifts complement(1825343) /Source="Nicolas_upshifts" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="upshifts" promotor_-35 complement(1825362..1825370) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-35" promotor_-35 1825396..1825405 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1825418..1825433 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" S_feature 1825420..1825506 /Source="Nicolas_S_feature" /locus_tag="new_2305261_2305347" /HighExp="Salt, T-0.40H, T-1.10H, Heat, T-1.40H, H2O2, T0.0H, Paraq, T0.30H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S825" upshifts 1825420 /Source="Nicolas_upshifts" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" promotor_-35 1825469..1825476 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1825491..1825510 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" upshifts 1825508 /Source="Nicolas_upshifts" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" CDS 1825537..1826442 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /EC_number="2.3.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5001847, 10939241, 11832514, 17056751, 18216013, 28581482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5001847, 10939241, 11832514, 17056751, 18216013, 28581482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="homoserine O-acetyltransferase" /protein_id="NP_390074.2" /db_xref="EnsemblGenomes-Gn:BSU21910" /db_xref="EnsemblGenomes-Tr:CAB14109" /db_xref="GOA:P54167" /db_xref="InterPro:IPR005697" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033752" /db_xref="SubtiList:BG11534" /db_xref="UniProtKB/Swiss-Prot:P54167" /translation="MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLM PKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDG MIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQM PKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAG VCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRW KAHATLLFMNWLNYYVYQETPYEWD*" /label="metAA CDS" gene 1825537..1826442 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /label="metAA gene" misc_feature 1826477..1826496 /Source="Nicolas_upshift_promotors" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1826491 /Source="Nicolas_upshifts" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" S_feature 1826492..1826672 /Source="Nicolas_S_feature" /locus_tag="new_2306333_2306513" /HighExp="Heat, HiTm, LoTm, C90, M9-stat, HiOs, SMM, UNK1, MG 25, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.999, 0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S826" CDS 1826673..1827821 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /EC_number="2.4.1.315" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose diacylglyceroltransferase" /protein_id="NP_390075.1" /db_xref="EnsemblGenomes-Gn:BSU21920" /db_xref="EnsemblGenomes-Tr:CAB14110" /db_xref="GOA:P54166" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR009695" /db_xref="InterPro:IPR023589" /db_xref="SubtiList:BG11611" /db_xref="UniProtKB/Swiss-Prot:P54166" /translation="MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQ ESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDE HQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKE KLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNV KELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDC MITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTS LLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS*" /label="ugtP CDS" gene 1826673..1827821 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /label="ugtP gene" S_feature complement(1826842..1827871) /Source="Nicolas_S_feature" /locus_tag="new_2306683_2307712_c" /HighExp="S8, S7, S6, C30, Lbstat, T0.30H, C90, BT, G135, Fru" /AntisenseName="ugtP" /AntisenseCor="-0.328222465122327" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S827" downshifts 1827817 /Source="Nicolas_upshifts" /id="D1146" /incds=0 /nref=77 /ntot=240 /MaxReadThrough="4.0787" /MaxDrop="4.20549" /score="21.6989702" /energy="-12.1" /TU="U1715,U1717" /idTUdmin="U1716" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1827853..1827872) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1827871) /Source="Nicolas_upshifts" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1827887..1827895) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1827902..1828048 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513973.1" /translation="MELALLLKNKPFRNLTGAPRWCIVEPSFNNESKLDDDKIFFSTW VLQY*" /label="hypothetical protein CDS" gene 1827902..1828048 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /label="gene" promotor_-35 1827941..1827948 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1827962..1827981 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1827973..1828063 /Source="Nicolas_S_feature" /locus_tag="new_2307814_2307904" /HighExp="C90, T5.0H, T3.30H, T3.0H, HiOs, Salt, LoTm, T-3.40H, S3, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S828" upshifts 1827973 /Source="Nicolas_upshifts" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1828064..1828264 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9920884, 16352840" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9920884, 16352840; Product type f: factor" /codon_start=1 /transl_table=11 /product="cold-shock protein, molecular chaperone, RNA-helicase co-factor" /protein_id="NP_390076.1" /db_xref="EnsemblGenomes-Gn:BSU21930" /db_xref="EnsemblGenomes-Tr:CAB14111" /db_xref="GOA:P51777" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11531" /db_xref="UniProtKB/Swiss-Prot:P51777" /translation="MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEG QEVSFEIVEGNRGPQASNVVKL*" /label="cspD CDS" gene 1828064..1828264 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /label="cspD gene" downshifts 1828279 /Source="Nicolas_upshifts" /id="D1147" /incds=0 /nref=257 /ntot=269 /MaxReadThrough="5.19931" /MaxDrop="8.09346" /score="9.24662311" /energy="-15.6" /TU="U1719" /idTUdmin="U1715" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS complement(1828316..1828498) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16625836, 19251843, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16625836, 19251843, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of degradative enzymes (aprE, nprE, sacB) production or activity" /protein_id="NP_390077.1" /db_xref="EnsemblGenomes-Gn:BSU21940" /db_xref="EnsemblGenomes-Tr:CAB14112" /db_xref="GOA:P68731" /db_xref="SubtiList:BG10699" /db_xref="UniProtKB/Swiss-Prot:P68731" /translation="MDDKDLKLILHKTFIEIYSDLEELADIAKKGKPSMEKYVEEIEQ RCKQNILAIEIQMKIK*" /label="degR CDS" gene complement(1828316..1828498) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /label="degR gene" S_feature 1828324..1828629 /Source="Nicolas_S_feature" /locus_tag="new_2308165_2308470" /HighExp="Cold, LoTm, T4.0H, T3.30H, Pyr, T5.0H, Gly, T3.0H, S0, C30" /AntisenseName="degR" /AntisenseCor="-0.145220711637392" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S829" downshifts complement(1828333) /Source="Nicolas_upshifts" /id="D1148" /incds=0 /nref=133 /ntot=216 /MaxReadThrough="3.75638" /MaxDrop="5.32427" /score="16.1392275" /energy="-7.3" /TU="U1720" /idTUdmin="U1720" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1828559..1828577) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1828591..1828597) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1828595) /Source="Nicolas_upshifts" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1828605..1828611 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1828626..1828637 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1828631 /Source="Nicolas_upshifts" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1828654..1828923 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390078.1" /db_xref="EnsemblGenomes-Gn:BSU21950" /db_xref="EnsemblGenomes-Tr:CAB14113" /db_xref="InterPro:IPR020314" /db_xref="SubtiList:BG13764" /db_xref="UniProtKB/Swiss-Prot:O32007" /translation="MTSEFHNEDQTGFTDKRQLELAVETAQKTTGAATRGQSKTLVDS AYQAIEDARELSQSEELAALDDPEFVKQQQQLLDDSEHQLDEFKE*" /label="ypzA CDS" gene 1828654..1828923 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /label="ypzA gene" downshifts 1828778 /Source="Nicolas_upshifts" /id="D1149" /incds=1 /nref=3 /ntot=82 /MaxReadThrough="6.79633" /MaxDrop="4.11501" /score="22.0113838" /energy="-7.3" /TU="U1719,U1721" /idTUdmin="U1719" /TUdmin="-117" /isTUend="FALSE" /label="downshifts" downshifts 1828906 /Source="Nicolas_upshifts" /id="D1150" /incds=0 /nref=18 /ntot=94 /MaxReadThrough="2.31821" /MaxDrop="6.65627" /score="22.0113838" /energy="-7.3" /TU="NA" /idTUdmin="U1719" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(1828951..1829133) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390079.1" /db_xref="EnsemblGenomes-Gn:BSU21960" /db_xref="EnsemblGenomes-Tr:CAB14114" /db_xref="InterPro:IPR019718" /db_xref="SubtiList:BG11610" /db_xref="UniProtKB/Swiss-Prot:P54165" /translation="MDKKMIFKELTELHDEYCKDCFIKKQFRKEFGKTYAHSFCINKC TVGEKLKQYGDVLTNH*" /label="ypeQ CDS" gene complement(1828951..1829133) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /label="ypeQ gene" downshifts complement(1828971) /Source="Nicolas_upshifts" /id="D1151" /incds=0 /nref=5 /ntot=102 /MaxReadThrough="2.77117" /MaxDrop="4.29218" /score="16.1392275" /energy="-7.3" /TU="NA" /idTUdmin="U1723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1829126..1829806) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12562816, 17905985, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 17905985, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease" /protein_id="NP_390080.2" /db_xref="EnsemblGenomes-Gn:BSU21970" /db_xref="EnsemblGenomes-Tr:CAB14115" /db_xref="GOA:P54164" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11609" /db_xref="UniProtKB/Swiss-Prot:P54164" /translation="MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMK ELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGG TRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSW PCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLD RNGDDDIG*" /label="ypeP CDS" gene complement(1829126..1829806) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /label="ypeP gene" S_feature complement(1829807..1829944) /Source="Nicolas_S_feature" /locus_tag="new_2309648_2309785_c" /HighExp="S5, S4, S6, S8, S7, S3, T5.0H, T4.0H, BT, Pyr" /AntisenseName="ypdP" /AntisenseCor="-0.65324924042743404" /AntisenseRegPval="-33.4" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.92, 0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S830" promotor_-35 1829823..1829828 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1829841..1829860 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1829846 /Source="Nicolas_upshifts" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1829889..1830578 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28208705; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preQ0 transporter (promiscuous)" /protein_id="NP_390081.1" /db_xref="EnsemblGenomes-Gn:BSU21980" /db_xref="EnsemblGenomes-Tr:CAB14116" /db_xref="GOA:P54163" /db_xref="InterPro:IPR003744" /db_xref="SubtiList:BG11607" /db_xref="UniProtKB/Swiss-Prot:P54163" /translation="MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQ VVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQG VLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLL WLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAA KKMIPNDERSS*" /label="queP CDS" gene 1829889..1830578 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /label="queP gene" promotor_-35 complement(1829942..1829958) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1829945) /Source="Nicolas_upshifts" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1829946..1830335) /Source="Nicolas_S_feature" /locus_tag="new_2309787_2310176_c" /HighExp="S5, S4, S6, S7, S8, T5.0H, S3, T4.0H, BT, M9-stat" /AntisenseName="ypdP" /AntisenseCor="-0.645700204826543" /AntisenseRegPval="-32.4" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S831" promotor_-10 complement(1830316..1830335) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1830333) /Source="Nicolas_upshifts" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1830347..1830355) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1830578..1830976 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9888800, 10094689, 15115438, 17905985; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein (no RNase H activity)" /protein_id="NP_390082.1" /db_xref="EnsemblGenomes-Gn:BSU21990" /db_xref="EnsemblGenomes-Tr:CAB14117" /db_xref="GOA:P54162" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11608" /db_xref="UniProtKB/Swiss-Prot:P54162" /translation="MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQE AEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAF PLFFIKWIPGKQNQKADLLAKEAIRLNEKN*" /label="ypdQ CDS" gene 1830578..1830976 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /label="ypdQ gene" promotor_-35 1830969..1830975 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1830990..1831001 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1831001 /Source="Nicolas_upshifts" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1831018..1831146 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054584.1" /db_xref="EnsemblGenomes-Gn:BSU22000" /db_xref="EnsemblGenomes-Tr:CAE01458" /db_xref="GOA:Q7WY66" /db_xref="InterPro:IPR017526" /db_xref="SubtiList:BG14176" /db_xref="UniProtKB/Swiss-Prot:Q7WY66" /translation="MKKKDKGRLTGGVTPQGDLEGNTHNDPKTELEERAKKSNTKR*" /label="sspL CDS" gene 1831018..1831146 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /label="sspL gene" S_feature 1831147..1832127 /Source="Nicolas_S_feature" /locus_tag="new_2310988_2311968" /HighExp="S8, S7, S5, S6, S4, C30, nit, ferm, Pyr, S3" /AntisenseName="exoA" /AntisenseCor="-0.365099613028674" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S832" CDS complement(1831154..1832044) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:16045613, 17038322, 17905985, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16045613, 17038322, 17905985, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5'3'-exonuclease" /protein_id="NP_390083.1" /db_xref="EnsemblGenomes-Gn:BSU22010" /db_xref="EnsemblGenomes-Tr:CAB14118" /db_xref="GOA:P54161" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="SubtiList:BG11606" /db_xref="UniProtKB/Swiss-Prot:P54161" /translation="MNNNKLLLVDGMALLFRAFFATAVHRNFMINDSGVPTNGVNGFL KHLITAVETFQPTHVVCCWDMGSKTYRNDLFQDYKANRSAPPVELIPQFDLAKEAAAE LGIMNIGFAGYEADDCIGTLADLFANEADITVVTGDRDLLQLLTDKVSVALLQKGIGN YKVYTKETFYEETGVMPKALIDIKALMGDSSDNYPGVKGIGEKTAYKLIREYETIDRL LENLSLLPKGQQGKIQQGLSDLEMSRKLAEIHCSVPLACTLKDALFTLQMEQAADMLR RHQIKGIERMLEKLNAREIV*" /label="exnP CDS" gene complement(1831154..1832044) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /label="exnP gene" downshifts complement(1831191) /Source="Nicolas_upshifts" /id="D1152" /incds=0 /nref=10 /ntot=174 /MaxReadThrough="2.94148" /MaxDrop="4.49836" /score="3.60870815" /energy="-15.6" /TU="U1726" /idTUdmin="U1726" /TUdmin="-284" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1832066..1832085) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1832073) /Source="Nicolas_upshifts" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1832097..1832103) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1832101 /Source="Nicolas_upshifts" /id="D1153" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="0.83304" /MaxDrop="4.41573" /score="0.126370352" /energy="-15" /TU="NA" /idTUdmin="U1725" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(1832145..1832291) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097753.1" /db_xref="EnsemblGenomes-Gn:BSU22019" /db_xref="EnsemblGenomes-Tr:CAX52652" /db_xref="UniProtKB/Swiss-Prot:C0H443" /translation="MLGRTKLGNRNAQANNNAKKKNGFQTHFDSYAGREAEKLIASNK RHND*" /label="ypzF CDS" gene complement(1832145..1832291) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /label="ypzF gene" downshifts complement(1832161) /Source="Nicolas_upshifts" /id="D1154" /incds=0 /nref=253 /ntot=272 /MaxReadThrough="0.89691" /MaxDrop="8.47168" /score="25.632979" /energy="-12" /TU="NA" /idTUdmin="U1727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1832315) /Source="Nicolas_upshifts" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1832316..1832327) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1832342..1832348) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1832366..1832623) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /experiment="publication(s) with functional evidences, PMID:20709900, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore associated protein" /protein_id="NP_390084.1" /db_xref="EnsemblGenomes-Gn:BSU22020" /db_xref="EnsemblGenomes-Tr:CAB14119" /db_xref="InterPro:IPR019688" /db_xref="SubtiList:BG11605" /db_xref="UniProtKB/Swiss-Prot:P54160" /translation="MSEVHKAISAHSSKQHEHIKAFMRLENMRELAIEEAVAKCRNDE PYTTDAINEITEQMNQLAKKGIVPTRRLVSKEMVREYVSRM*" /label="ypbS CDS" gene complement(1832366..1832623) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /label="ypbS gene" promotor_-10 complement(1832643..1832662) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1832658) /Source="Nicolas_upshifts" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1832674..1832681) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1832688..1836269) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /EC_number="3.6.5.5" /experiment="publication(s) with functional evidences, PMID:21205012, 23388828, 23249255, 26842743, 26530236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21205012, 23388828, 23249255, 26842743, 26530236; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dynamin GTPase" /protein_id="NP_390085.1" /db_xref="EnsemblGenomes-Gn:BSU22030" /db_xref="EnsemblGenomes-Tr:CAB14120" /db_xref="GOA:P54159" /db_xref="InterPro:IPR022812" /db_xref="InterPro:IPR027094" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11604" /db_xref="UniProtKB/Swiss-Prot:P54159" /translation="MTDQNRKELLHKTGELYKQFIENQDEQRAAKLAAVMKKAADEEV YIAFTGHYSAGKSSLLNCLLMENILPTSPIPTSANLVVIRNGEKRVRLHTTDGACAEL EGTYQKDKVQQYCKDGEQIESVEIFDRYTEIDSGVAYIDTPGIDSTDDAHFLSAASIL HQADALFYVVHYNHVHAEENVKFLRSIKESIPNVYFIVNQIDRHDETETKFGDYQAQV EEMLCNEGISREALYFTSVTEPDHPFNQMGALREELSRIEQQSKSNMQALTEQKVRNL LKEHTEMLKKDETGAPSFAEQLNIHTGLVQSLRDQLDEAEKQMTEAEKRMQEEINRIL KNANLTPFEMRELAAAFLESQEPSFKTGFFFSKAKTAQERDKRRNAFFSDVAKRTEAE ADWHMIDTLHKLAKVFDVYTAESEKLIQAYRTPLDISIIEHAVKHGAAFSSEYVLQYT KDLAELIRKEAKREAADIIKVLSAMVKERVSKDVQTINDRLVQESEKLVFLQEQARLE NNAREKTDRLWAIWEEESACPMHIDTEWFKSKKTRVAAPEQKQGRSQLTAQPMPKSEI KMEQEMPLQDQIKRFYTLSDILGECSMLLKQTSAFRERVKRLEERKFTLALFGGFSSG KSSFANALVGERVLPSSPTPTTATINKITKPINGNLNKTANVVFKTEDDLTAEILQLT GIPKEPAGRSFTEKWEKAVKKNRLQEEHVKLISNFLLAYEKYQQYIQEQKKLTIPLSE LKPYVAEETTACAVKEVTVYYTCPLTEKGITIVDTPGASSMNKRHTELAFQYIKDADA FFYMTYYQHSFSKGDRSFLRKLGLVKESLSMDKMFFIINAADLAKDKTELETVTDYVS AELVKEGVYEPQLFTVSSKEELVGKPESFYNQFSKVRKHLDRFIEVDVKKASAAQLSS EADKLCETVFQLHQSQHQSREEKEAQKQCLMLSFERTAADIEKRRNSKTIIEKVKKDT REQLYHIAQRLSYFANDLLKSAFHPGLQNGDWKKNVSKAMTTALHEYLFEYIQEIKTL DVRMSGFIERHINEEWLDHFQKTLNEDGYFSVYAGDQHSNGIQLKEVEPEIEERAFEQ ELKEIKSPKQFFEQKGKATFIEAVRMKLTKITEAWIKNEEESLISHYTAHLRRLQEDM GEKAIAQITDQKETYLRGYAEGEHAKEIEMAYQACISWKNSDNTIKM*" /label="dynA CDS" gene complement(1832688..1836269) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /label="dynA gene" S_feature complement(1836270..1836341) /Source="Nicolas_S_feature" /locus_tag="new_2316111_2316182_c" /HighExp="LBGstat, T1.30H, T1.0H, BMM, T2.30H, M9-stat, MG 150, T0.30H, T2.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S833" misc_feature complement(1836331..1836350) /Source="Nicolas_upshift_promotors" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1836341) /Source="Nicolas_upshifts" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="upshifts" S_feature complement(1836386..1836583) /Source="Nicolas_S_feature" /locus_tag="new_2316227_2316424_c" /HighExp="HiOs, B60, GM 25, S7, GM 15, B36, S5, S8, GM 5, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.24118200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S834" downshifts complement(1836429) /Source="Nicolas_upshifts" /id="D1155" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.11615" /MaxDrop="3.46525" /score="27.1937922" /energy="-9.7" /TU="U1730" /idTUdmin="U1730" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1836445..1836534) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513974.1" /db_xref="EnsemblGenomes-Gn:BSU22036" /db_xref="EnsemblGenomes-Tr:CCQ48599" /db_xref="UniProtKB/TrEMBL:L8ECR0" /translation="MTMLFLLGAVCTYSVLIGFVLKGISNKSV*" /label="fbpC CDS" gene complement(1836445..1836534) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /label="fbpC gene" promotor_-10 complement(1836562..1836581) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1836583) /Source="Nicolas_upshifts" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1836596..1836603) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1836605..1837111) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /EC_number="2.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 7726551, 8396117, 19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 7726551, 8396117, 19465653; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkylpyrone methyltransferase (polyketide synthesis)" /protein_id="NP_390086.1" /db_xref="EnsemblGenomes-Gn:BSU22040" /db_xref="EnsemblGenomes-Tr:CAB14121" /db_xref="GOA:P54158" /db_xref="InterPro:IPR007269" /db_xref="SubtiList:BG11603" /db_xref="UniProtKB/Swiss-Prot:P54158" /translation="MFWLLIAILIVQRAAEMAVARQNEQKVKKQGAIEFGESHYPYII TMHILFFLSLIAEVLLMNKQPSSWWLGIAAVILSVQIVRYWALCSLGAYWNTKILVVP GVELVKKGPYKWMKHPNYAVVILEILLIPLLYQAYVTMCLFSIFNAVLLSVRIRAEDK ALQEYSVK*" /label="bpsB CDS" gene complement(1836605..1837111) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /label="bpsB gene" CDS complement(1837115..1838212) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /EC_number="2.3.1.-" /function="15.10: Adaptations to atypical conditions" /experiment="publication(s) with functional evidences, PMID:19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19465653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous alkylpyrone synthase BpsA (polyketide synthesis)" /protein_id="NP_390087.1" /db_xref="EnsemblGenomes-Gn:BSU22050" /db_xref="EnsemblGenomes-Tr:CAB14122" /db_xref="GOA:P54157" /db_xref="InterPro:IPR001099" /db_xref="InterPro:IPR011141" /db_xref="InterPro:IPR012328" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018088" /db_xref="SubtiList:BG11523" /db_xref="UniProtKB/Swiss-Prot:P54157" /translation="MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFK NGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYE KVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKA YPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLA PKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSF HDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQN GHKKEAERGLIGALGPGFSSELLLFSWEKGA*" /label="bpsA CDS" gene complement(1837115..1838212) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /label="bpsA gene" promotor_-10 complement(1838230..1838241) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1838233) /Source="Nicolas_upshifts" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1838256..1838262) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1838286..1839602) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098051, 12923093, 15549109, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098051, 12923093, 15549109, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xanthine permease" /protein_id="NP_390088.1" /db_xref="EnsemblGenomes-Gn:BSU22060" /db_xref="EnsemblGenomes-Tr:CAB14123" /db_xref="GOA:P42086" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG11080" /db_xref="UniProtKB/Swiss-Prot:P42086" /translation="MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYL VSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIA SGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQ PFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLA VLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFGLFPKIAAFTTIIPS AVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPS ALTLLTTNGIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV*" /label="pbuX CDS" gene complement(1838286..1839602) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /label="pbuX gene" downshifts complement(1838299) /Source="Nicolas_upshifts" /id="D1156" /incds=0 /nref=177 /ntot=215 /MaxReadThrough="1.81377" /MaxDrop="6.3089" /score="32.8866099" /energy="-9" /TU="U1733" /idTUdmin="U1732" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1839599..1840183) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /EC_number="2.4.2.22" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12923093, 15549109, 19381559, 20108980, 20200045" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15549109, 19381559, 20108980, 20200045; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine phosphoribosyltransferase" /protein_id="NP_390089.1" /db_xref="EnsemblGenomes-Gn:BSU22070" /db_xref="EnsemblGenomes-Tr:CAB14124" /db_xref="GOA:P42085" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010079" /db_xref="InterPro:IPR029057" /db_xref="PDB:1Y0B" /db_xref="PDB:2FXV" /db_xref="SubtiList:BG11079" /db_xref="UniProtKB/Swiss-Prot:P42085" /translation="MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFAS RFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQ TESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQP GRDELVKLGYRVESLARIQSLEEGKVSFVQEVHS*" /label="xpt CDS" gene complement(1839599..1840183) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /label="xpt gene" misc_RNA complement(1840272..1840372) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswA RNA" gene complement(1840272..1840372) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /label="gswA gene" downshifts complement(1840279) /Source="Nicolas_upshifts" /id="D1157" /incds=0 /nref=8 /ntot=35 /MaxReadThrough="6.97435" /MaxDrop="3.25" /score="36.5247418" /energy="-19.2" /TU="U1732,U1733" /idTUdmin="U1734" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" S_feature complement(1840373..1840513) /Source="Nicolas_S_feature" /locus_tag="new_2320214_2320354_c" /HighExp="dia15, BT, dia5, Diami, C90, LBGtran, Lbtran, Gly, SMMPr, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.291, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S835" CDS complement(1840514..1842019) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /EC_number="3.4.17.19" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7765282, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="metal-dependent carboxypeptidase" /protein_id="NP_390090.1" /db_xref="EnsemblGenomes-Gn:BSU22080" /db_xref="EnsemblGenomes-Tr:CAB14125" /db_xref="GOA:P50848" /db_xref="InterPro:IPR001333" /db_xref="PDB:3HQ2" /db_xref="SubtiList:BG11458" /db_xref="UniProtKB/Swiss-Prot:P50848" /translation="MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRA ESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAE YKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDL FEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQ ELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNI DEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDD FVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYL GITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEF HPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL*" /label="ypwA CDS" gene complement(1840514..1842019) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /label="ypwA gene" promotor_no_box complement(1841955..1842055) /Source="Nicolas_upshift_promotors" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1841995) /Source="Nicolas_upshifts" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" downshifts 1842007 /Source="Nicolas_upshifts" /id="D1158" /incds=0 /nref=4 /ntot=78 /MaxReadThrough="1.34397" /MaxDrop="3.87399" /score="12.6922524" /energy="-13.3" /TU="NA" /idTUdmin="U1735" /TUdmin="-5588" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1842045..1842064) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1842061) /Source="Nicolas_upshifts" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1842078..1842085) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1842131..1843123) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 9846747; Product type t: transporter" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate permease" /protein_id="NP_390091.1" /db_xref="EnsemblGenomes-Gn:BSU22090" /db_xref="EnsemblGenomes-Tr:CAB14126" /db_xref="GOA:P50847" /db_xref="InterPro:IPR004684" /db_xref="InterPro:IPR018395" /db_xref="SubtiList:BG11399" /db_xref="UniProtKB/Swiss-Prot:P50847" /translation="MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALI TGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQ SGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGV TGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGM LIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEA NASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN*" /label="kdgT CDS" gene complement(1842131..1843123) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /label="kdgT gene" downshifts complement(1842149) /Source="Nicolas_upshifts" /id="D1159" /incds=0 /nref=15 /ntot=59 /MaxReadThrough="3.32882" /MaxDrop="5.85236" /score="36.5247418" /energy="-19.2" /TU="NA" /idTUdmin="U1734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1843168..1843758) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /EC_number="4.1.2.14" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate-6-phosphate aldolase" /protein_id="NP_390092.1" /db_xref="EnsemblGenomes-Gn:BSU22100" /db_xref="EnsemblGenomes-Tr:CAB14127" /db_xref="GOA:P50846" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031338" /db_xref="SubtiList:BG11396" /db_xref="UniProtKB/Swiss-Prot:P50846" /translation="MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEV TYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLS FVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGI HPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV*" /label="kdgA CDS" gene complement(1843168..1843758) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /label="kdgA gene" CDS complement(1843760..1844734) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /EC_number="2.7.1.45" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143, 15039578; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate kinase" /protein_id="NP_390093.1" /db_xref="EnsemblGenomes-Gn:BSU22110" /db_xref="EnsemblGenomes-Tr:CAB14128" /db_xref="GOA:P50845" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG11397" /db_xref="UniProtKB/Swiss-Prot:P50845" /translation="MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGL ARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDP QVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAG KTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYL KKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLS YKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY*" /label="kdgK CDS" gene complement(1843760..1844734) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /label="kdgK gene" CDS complement(1844772..1845791) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9846747, 15223311, 17322190, 28040177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9846747, 15223311, 17322190, 28040177; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the Kdg operon (KdgR-galacturonate)" /protein_id="NP_390094.1" /db_xref="EnsemblGenomes-Gn:BSU22120" /db_xref="EnsemblGenomes-Tr:CAB14129" /db_xref="GOA:P50844" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG11398" /db_xref="UniProtKB/Swiss-Prot:P50844" /translation="MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNI KKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMV CNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLK LDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNG LVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQD IGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVI MRKSL*" /label="kdgR CDS" gene complement(1844772..1845791) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /label="kdgR gene" promotor_-10 complement(1845839..1845858) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1845849) /Source="Nicolas_upshifts" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1845870..1845877) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1845912..1845919 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1845933..1846012 /Source="Nicolas_S_feature" /locus_tag="new_2325774_2325853" /HighExp="HiTm, Heat, nit, LBGstat, ferm, T-0.40H, HiOs, T1.30H, MG 150, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S836" upshifts 1845933 /Source="Nicolas_upshifts" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1845934..1845953 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1846013..1846840 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /EC_number="5.3.1.17" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 23437267, 27227414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase" /protein_id="NP_390095.1" /db_xref="EnsemblGenomes-Gn:BSU22130" /db_xref="EnsemblGenomes-Tr:CAB14130" /db_xref="GOA:P50843" /db_xref="InterPro:IPR007045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR027449" /db_xref="SubtiList:BG11401" /db_xref="UniProtKB/Swiss-Prot:P50843" /translation="MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDR VVIGGAAPGQSELKLDAGDFLKTDFFLERREIGIINVGQPGAVRVGDDEYVLQTKDFL YIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGDDAASNVRSL YKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMG QPDETRHLVVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK* " /label="kduI CDS" gene 1846013..1846840 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /label="kduI gene" CDS 1846842..1847606 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /EC_number="1.1.1.127" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 24509771, 27028675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate oxidoreductase" /protein_id="NP_390096.1" /db_xref="EnsemblGenomes-Gn:BSU22140" /db_xref="EnsemblGenomes-Tr:CAB14131" /db_xref="GOA:P50842" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011286" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11400" /db_xref="UniProtKB/Swiss-Prot:P50842" /translation="MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSH TSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREK AEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYT ASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGR WGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR*" /label="kduD CDS" gene 1846842..1847606 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /label="kduD gene" downshifts 1847595 /Source="Nicolas_upshifts" /id="D1160" /incds=0 /nref=12 /ntot=160 /MaxReadThrough="0.66029" /MaxDrop="3.56178" /score="23.0070487" /energy="-12.3" /TU="NA" /idTUdmin="U1735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1847637) /Source="Nicolas_upshifts" /id="D1161" /incds=0 /nref=28 /ntot=225 /MaxReadThrough="1.88107" /MaxDrop="5.27501" /score="35.5168663" /energy="-12.3" /TU="NA" /idTUdmin="U1736" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(1847647..1849572) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /EC_number="3.6.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8385320, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent helicase" /protein_id="NP_390097.1" /db_xref="EnsemblGenomes-Gn:BSU22150" /db_xref="EnsemblGenomes-Tr:CAB14132" /db_xref="GOA:P50831" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11457" /db_xref="UniProtKB/Swiss-Prot:P50831" /translation="MTTSRLPFSLTKTKNFYEELNNWIGDVFYDILPEKGFDLRDEQV FMAFQLERAFKEKKVMFAEAGVGTGKTLVYLLFAISYARYVGKPAIIACADETLIEQL VKKEGDISKLAEHLDLKIDTRLSKSHEQYLCLKKLEKTMQRSDDDKWLDLYESLPSFV HESQAMQRFYPYGDRKQYANLSNEEWSDVSYDSFQDCLTCDMRHRCGLTLSRDYYRKS TDLIICSHDFYMEHVWTEESRKREGQLPLLPDHSAVVFDEGHLLEFAAQKALTYRVKQ STLELFLERLLQNDIREEFAELIEDALLANDEFFYVLSEESKEVAGSHRLEIKNDHRV KKAADELCRLLDKIGEALVFESEMYTIDQYELSVVEEYVEQMAYSLSLYQKDAISWLE KKEAESTFVVMPRTVAEVLGEKVFSKKIPYIFSSATLSEGGSFDYIADSLGIHDYLSL TVDSPYDYDEQMSINLYAKTDMDAEQKTAETIETIKRYKGRTLVLFPSFEELNEFKEL SAAWELPYPIFFEGDEEISSLVEKFQEEEETVLCSVHLWEGLDIPGDALKNVTIWSLP FPPHDPVFTAKRNGAKKDPFEEVDLPYMLLRVRQGIGRLIRSNQDSGSIHIYAGGENE RIIDEVKKVLPVEPHMM*" /label="ypvA CDS" gene complement(1847647..1849572) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /label="ypvA gene" promotor_-10 complement(1849603..1849622) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1849607) /Source="Nicolas_upshifts" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1849609..1849673) /Source="Nicolas_S_feature" /locus_tag="new_2329450_2329514_c" /HighExp="S3, S4, S8, S7, LoTm, S5, S6, BT, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S837" promotor_-35 complement(1849637..1849641) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1849674..1849865) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390098.1" /db_xref="EnsemblGenomes-Gn:BSU22160" /db_xref="EnsemblGenomes-Tr:CAB14133" /db_xref="SubtiList:BG11456" /db_xref="UniProtKB/Swiss-Prot:P50841" /translation="MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAV EHIYSTDHPFLSSHVINRK*" /label="yptA CDS" gene complement(1849674..1849865) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /label="yptA gene" promotor_-10 complement(1849884..1849902) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1849893) /Source="Nicolas_upshifts" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1849895..1850200) /Source="Nicolas_S_feature" /locus_tag="new_2329736_2330041_c" /HighExp="Cold, G135, G180, C30, G150, Oxctl, Paraq, H2O2, LBGstat, LPh" /AntisenseName="ypzG" /AntisenseCor="-0.39420155633160697" /AntisenseRegPval="-10.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S838" promotor_-35 complement(1849918..1849923) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1849932..1849938 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1849953..1849964 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1849962 /Source="Nicolas_upshifts" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="upshifts" CDS 1850029..1850181 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097754.1" /db_xref="EnsemblGenomes-Gn:BSU22169" /db_xref="EnsemblGenomes-Tr:CAX52653" /db_xref="InterPro:IPR025413" /db_xref="UniProtKB/Swiss-Prot:C0H444" /translation="MSYRNRLDQHSELFHHNWTRPKRSKSQVNGHTEMSQTNIILRSN AKAHRW*" /label="ypzG CDS" gene 1850029..1850181 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /label="ypzG gene" downshifts 1850191 /Source="Nicolas_upshifts" /id="D1162" /incds=0 /nref=35 /ntot=65 /MaxReadThrough="1.2837" /MaxDrop="7.64655" /score="-9.36260071" /energy="-16.3" /TU="NA" /idTUdmin="U1738" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1850234..1851391) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /EC_number="2.1.1.264" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22210896, 22362734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="m(7)G2069 methylase of 23S rRNA" /protein_id="NP_390099.1" /db_xref="EnsemblGenomes-Gn:BSU22170" /db_xref="EnsemblGenomes-Tr:CAB14134" /db_xref="GOA:P50840" /db_xref="InterPro:IPR000241" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11455" /db_xref="UniProtKB/Swiss-Prot:P50840" /translation="MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALA ICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKST LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTG LHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAP GFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEA GLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTW SVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA*" /label="rlmKB CDS" gene complement(1850234..1851391) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /label="rlmKB gene" downshifts complement(1850245) /Source="Nicolas_upshifts" /id="D1163" /incds=0 /nref=86 /ntot=240 /MaxReadThrough="4.31441" /MaxDrop="4.58268" /score="14.6684819" /energy="-6.2" /TU="U1739" /idTUdmin="U1740" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1851479..1851879) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /product="RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)" /experiment="publication(s) with functional evidences, PMID:1699929, 16980484, 17919279, 22448220" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1699929, 16980484, 17919279, 22448220; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rnpB RNA" gene complement(1851479..1851879) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /label="rnpB gene" downshifts complement(1851489) /Source="Nicolas_upshifts" /id="D1164" /incds=0 /nref=200 /ntot=276 /MaxReadThrough="6.17541" /MaxDrop="7.4677" /score="0.20729905" /energy="-10.4" /TU="U1739,U1740" /idTUdmin="U1742" /TUdmin=406 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1851876..1851895) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1851894) /Source="Nicolas_upshifts" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1851910..1851916) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1851938..1852234) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:18363795, 18776011, 19429628, 25845974, 27257764" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18363795, 18776011, 19429628, 25845974, 27257764; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell division protein" /protein_id="NP_390100.1" /db_xref="EnsemblGenomes-Gn:BSU22180" /db_xref="EnsemblGenomes-Tr:CAB14135" /db_xref="GOA:P0CI74" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR011229" /db_xref="InterPro:IPR019933" /db_xref="PDB:4UG3" /db_xref="PDB:5AN5" /db_xref="SubtiList:BG11454" /db_xref="UniProtKB/Swiss-Prot:P0CI74" /translation="MLADKVKLSAKEILEKEFKTGVRGYKQEDVDKFLDMIIKDYETF HQEIEELQQENLQLKKQLEEASKKQPVQSNTTNFDILKRLSNLEKHVFGSKLYD*" /label="gpsB CDS" gene complement(1851938..1852234) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /label="gpsB gene" promotor_-10 complement(1852259..1852278) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1852269) /Source="Nicolas_upshifts" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1852292..1852299) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1852312..1852941) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390101.2" /db_xref="EnsemblGenomes-Gn:BSU22190" /db_xref="EnsemblGenomes-Tr:CAB14136" /db_xref="InterPro:IPR010697" /db_xref="PDB:2NX2" /db_xref="SubtiList:BG11453" /db_xref="UniProtKB/Swiss-Prot:P50838" /translation="MENVQLDGVNNAAQQMGPTGAPFFKAGEMMKVLAITGYKPFELG IFKQDDKALYYIKKAIKNRLIAFLDEGLEWILISGQLGVELWAAEAAYDLQEEYPDLK VAVITPFYEQEKNWKEPNKEQYEAVLAQADYEASLTHRPYESPLQFKQKNQFFIDKSD GLLLLYDPEKEGSPKYMLGTAEKRREQDGYPIYFITMDDLRVTVEEDSY*" /label="ypsA CDS" gene complement(1852312..1852941) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /label="ypsA gene" downshifts complement(1852907) /Source="Nicolas_upshifts" /id="D1165" /incds=0 /nref=37 /ntot=160 /MaxReadThrough="5.74028" /MaxDrop="8.12374" /score="7.18626302" /energy="-9.8" /TU="U1741,U1742" /idTUdmin="U1744" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1852943..1853170) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2821284, 10075739, 10400595, 1518043, 1691789, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2821284, 10075739, 10400595, 1518043, 1691789, 19933362; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner)" /protein_id="NP_390102.1" /db_xref="EnsemblGenomes-Gn:BSU22200" /db_xref="EnsemblGenomes-Tr:CAB14137" /db_xref="GOA:P07791" /db_xref="InterPro:IPR020108" /db_xref="SubtiList:BG10493" /db_xref="UniProtKB/Swiss-Prot:P07791" /translation="MHHCRPHMMAPIVHPTHCCEHHTFSKTIVPHIHPQHTTNVNHQH FQHVHYFPHTFSNVDPATHQHFQAGKPCCDY*" /label="cotD CDS" gene complement(1852943..1853170) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /label="cotD gene" promotor_-10 complement(1853198..1853217) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-10" upshifts complement(1853213) /Source="Nicolas_upshifts" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="upshifts" S_feature complement(1853215..1853369) /Source="Nicolas_S_feature" /locus_tag="new_2333056_2333210_c" /HighExp="LBGexp, dia15, Paraq, H2O2, Heat, G135, UNK1, Lbexp, BMM, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.808141" /TUshortSig="SigA, Sig-, SigA, SigA" /TUshortPSig="1, 0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S839" promotor_-35 complement(1853231..1853239) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-35" CDS complement(1853254..1853382) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513975.1" /translation="MTLVIFKGRVGMYKGVFYLFFVVVFLIAFVFSNFKDSLIAHF*" /label="conserved protein of unknown function CDS" gene complement(1853254..1853382) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /label="gene" upshifts complement(1853369) /Source="Nicolas_upshifts" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" S_feature complement(1853371..1853482) /Source="Nicolas_S_feature" /locus_tag="new_2333212_2333323_c" /HighExp="Sw, M40t90, Etha, Salt, M40t45, H2O2, S8, S6, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S840" promotor_-10 complement(1853372..1853391) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" promotor_-35 complement(1853407..1853411) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1853483..1854724) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23249255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding enzyme" /protein_id="NP_390103.1" /db_xref="EnsemblGenomes-Gn:BSU22210" /db_xref="EnsemblGenomes-Tr:CAB14138" /db_xref="GOA:P50837" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11452" /db_xref="UniProtKB/Swiss-Prot:P50837" /translation="MSLKGKLQRMKKHMALDEGEQKIEAGKQENHFDDIPFLEEWEAF GMKPFIFEDEYCLIREVEYPLSHRHGLYSFSELEEVITLWNQSGLSHTLSAKGYNKNN LFFFDTETTGLGGGAGNTIFLLGHARVYEDRVTVKQHLLPKPGNEVALYQSFLSEVDI TSLVTYNGKAFDWPQVKTRHTLIRDRLPKLPEFGHFDLLHGARRLWKHKMDRVSLGTV EKEELGIRRLEDTPGYLAPMLYFHFIKAQEPDLLKGVLHHNEMDVLSLISLYIHMSKK ILSESHAPKEHSEAYAMAKWFMAHKETDQAIKQLERLIEKSFEDQDSARLDLSLLYKK QNRLEEAVPLWEKLSRSQNQKCRYAAVIELAKYFEHKKKEFGKALQVAEQSLSDAACL SEKETEKLHVRIARLKRKYSS*" /label="yprB CDS" gene complement(1853483..1854724) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /label="yprB gene" promotor_-10 complement(1854438..1854456) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-10" upshifts complement(1854447) /Source="Nicolas_upshifts" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="upshifts" promotor_-35 complement(1854471..1854478) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-35" CDS complement(1854740..1856989) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /EC_number="3.6.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_390104.1" /db_xref="EnsemblGenomes-Gn:BSU22220" /db_xref="EnsemblGenomes-Tr:CAB14139" /db_xref="GOA:P50830" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018973" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11451" /db_xref="UniProtKB/Swiss-Prot:P50830" /translation="MKKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIK AALSKRGIDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRA LYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHIVITNPDM LHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIRRLKRICRFYGSDPVF ICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRKHFVFYNPPIVNKPLNIRRSATAE VNELAKEFLKNKVQTIVFARSRVRVEIILSHIQELVKKEIGTKSIRGYRGGYLPKERR EIERGLREGDILGVVSTNALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGES LIIMVANSTPIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEE FGAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDIAN VRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDVEYYTDANLAV QLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEELHTS AAWLEIKTADEDIGEKTLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGLP TIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKER ILQLLDQMS*" /label="yprA CDS" gene complement(1854740..1856989) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /label="yprA gene" promotor_-10 complement(1857005..1857024) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1857021) /Source="Nicolas_upshifts" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1857038..1857044) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1857092..1857598) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10627040, 28731580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase system enzyme IIA component" /protein_id="NP_390105.1" /db_xref="EnsemblGenomes-Gn:BSU22230" /db_xref="EnsemblGenomes-Tr:CAB14140" /db_xref="GOA:P50829" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG11450" /db_xref="UniProtKB/Swiss-Prot:P50829" /translation="MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMM GEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFT AHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGES KLFTIKAK*" /label="ypqE CDS" gene complement(1857092..1857598) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /label="ypqE gene" downshifts complement(1857115) /Source="Nicolas_upshifts" /id="D1166" /incds=0 /nref=88 /ntot=236 /MaxReadThrough="4.55156" /MaxDrop="6.1724" /score="32.5355561" /energy="-10.2" /TU="U1745" /idTUdmin="U1747" /TUdmin=808 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1857642..1857661) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1857659) /Source="Nicolas_upshifts" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1857675..1857682) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" promotor_-35 1857680..1857689 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1857703..1857722 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1857715 /Source="Nicolas_upshifts" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="upshifts" CDS 1857736..1858155 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_390106.1" /db_xref="EnsemblGenomes-Gn:BSU22240" /db_xref="EnsemblGenomes-Tr:CAB14141" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11449" /db_xref="UniProtKB/Swiss-Prot:P50836" /translation="MEFHDDKKNELQKKEEIITEAIDTLFQSSAFGNLINGFQNLINS SLKDVQTTIHVRERDTGLYIDITIPATFRDGEIVVDVKSRYLHVTLQEKQKHQNEATF TSMTRTVQLPYEVRQEDMETSWNEQTMTLFFPKNKHE*" /label="ypqA CDS" gene 1857736..1858155 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /label="ypqA gene" S_feature 1858156..1858306 /Source="Nicolas_S_feature" /locus_tag="new_2337997_2338147" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, nit" /AntisenseName="yppG" /AntisenseCor="0.95679380325708796" /AntisenseRegPval="-144.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S841" CDS complement(1858176..1858553) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein; methionine-glutamine-rich protein" /protein_id="NP_390107.1" /db_xref="EnsemblGenomes-Gn:BSU22250" /db_xref="EnsemblGenomes-Tr:CAB14142" /db_xref="InterPro:IPR025555" /db_xref="SubtiList:BG11448" /db_xref="UniProtKB/Swiss-Prot:P50835" /translation="MNGSSRSYPRQMGYYYPQHMQGYYQQAAPGYLEQQLPQQHYGQQ DYYQPYAPIQPMPMQPPVFSNPYPIPRPNQQQPSQFQSIMSQFKKANGQFDFNKMMDT TGQVMSAMNQVGSLIKGFTSFFK*" /label="yppG CDS" gene complement(1858176..1858553) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /label="yppG gene" downshifts complement(1858209) /Source="Nicolas_upshifts" /id="D1167" /incds=0 /nref=10 /ntot=43 /MaxReadThrough="3.01854" /MaxDrop="4.7006" /score="0.85617333" /energy="-12.8" /TU="U1747" /idTUdmin="U1747" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature 1858551..1858696 /Source="Nicolas_S_feature" /locus_tag="new_2338392_2338537" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, C30" /AntisenseName="yppG" /AntisenseCor="0.96504903995490698" /AntisenseRegPval="-156.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S842" promotor_-10 complement(1858583..1858601) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1858602) /Source="Nicolas_upshifts" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1858615..1858624) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1858697..1858716 /Source="Nicolas_upshift_promotors" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1858698 /Source="Nicolas_upshifts" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1858741..1858929 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390108.1" /db_xref="EnsemblGenomes-Gn:BSU22260" /db_xref="EnsemblGenomes-Tr:CAB14143" /db_xref="InterPro:IPR025553" /db_xref="SubtiList:BG11447" /db_xref="UniProtKB/Swiss-Prot:P50834" /translation="MNVSYLSKRFAEMKKYETDCMNKLMDFAKFLYIQGHLSITEFRN SMKVLEANGAESPAYEMN*" /label="yppF CDS" gene 1858741..1858929 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /label="yppF gene" downshifts 1858945 /Source="Nicolas_upshifts" /id="D1168" /incds=0 /nref=112 /ntot=242 /MaxReadThrough="3.3677" /MaxDrop="5.69944" /score="0.283992322" /energy="-8.5" /TU="U1748" /idTUdmin="U1748" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" CDS complement(1858968..1859339) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390109.1" /db_xref="EnsemblGenomes-Gn:BSU22270" /db_xref="EnsemblGenomes-Tr:CAB14144" /db_xref="InterPro:IPR014913" /db_xref="InterPro:IPR023351" /db_xref="PDB:2HFI" /db_xref="PDB:2IM8" /db_xref="SubtiList:BG11446" /db_xref="UniProtKB/Swiss-Prot:P50833" /translation="MLSQTLLEMTEQMIEVAEKGADRYQEGKNSNHSYDFFETIKPAV EENDELAARWAEGALELIKVRRPKYVHKEQIEAVKDNFLELVLQSYVHHIHKKRFKDI TESVLYTLHAVKDEIAREDSR*" /label="yppE CDS" gene complement(1858968..1859339) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /label="yppE gene" downshifts complement(1859001) /Source="Nicolas_upshifts" /id="D1169" /incds=0 /nref=158 /ntot=245 /MaxReadThrough="1.04225" /MaxDrop="5.78413" /score="-2.77698308" /energy="-10.3" /TU="NA" /idTUdmin="U1749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1859351..1859370) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1859364) /Source="Nicolas_upshifts" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1859383..1859388) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1859385..1859630) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15687200; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390110.1" /db_xref="EnsemblGenomes-Gn:BSU22280" /db_xref="EnsemblGenomes-Tr:CAB14145" /db_xref="InterPro:IPR020252" /db_xref="SubtiList:BG11445" /db_xref="UniProtKB/Swiss-Prot:P50832" /translation="MSGYVCKTDILRMLSDIEDELTRAEQSLNHSVNALEAEMRETEN DRLSVLEEEIIDLHICINELYQSPEHRYAFEKVYRIG*" /label="yppD CDS" gene complement(1859385..1859630) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /label="yppD gene" promotor_-10 complement(1859656..1859674) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1859661) /Source="Nicolas_upshifts" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1859686..1859694) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1859780..1859786 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1859801..1859812 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1859808 /Source="Nicolas_upshifts" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="upshifts" CDS 1859829..1859933 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054585.1" /db_xref="EnsemblGenomes-Gn:BSU22290" /db_xref="EnsemblGenomes-Tr:CAE01459" /db_xref="GOA:Q7WY65" /db_xref="SubtiList:BG14177" /db_xref="UniProtKB/Swiss-Prot:Q7WY65" /translation="MKTRPKKAGQQKKTESKAIDSLDKKLGGPNRPST*" /label="sspM CDS" gene 1859829..1859933 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /label="sspM gene" downshifts 1859915 /Source="Nicolas_upshifts" /id="D1170" /incds=0 /nref=31 /ntot=49 /MaxReadThrough="1.6498" /MaxDrop="6.01285" /score="0.283992322" /energy="-8.5" /TU="NA" /idTUdmin="U1751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1859958..1860920) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390111.1" /db_xref="EnsemblGenomes-Gn:BSU22300" /db_xref="EnsemblGenomes-Tr:CAB14146" /db_xref="InterPro:IPR019658" /db_xref="SubtiList:BG10952" /db_xref="UniProtKB/Swiss-Prot:P39791" /translation="MNVQEQQAIRKLLSRIERQTKMKNADNISRTNAYKAFYDRHPEI KWSLLASFVSRNAGWSMTDLKGSLFQLGLRERQQKWFFLAYERANWLIFSDAYPQLLL YHWSKRVGKPLFHLLHVFGVSQFMSEEWTRFWHERNTERLMYALIINEQNTIQTPIIQ NPSFKKNVFDTIPFYLSDWFHFNTVIFPSSNGFFYGISVKRFSKAEERIRLGKQLSQL LFKPELFSSFYHFLHTVPHTGSRFDMEKMIGITKRTSPMLRTCYPELIHSLDGTKTDW FHGKIKKTFFRREELPKQIELTDWYLHKKRQLHALFAVEQWLKK*" /label="yppC CDS" gene complement(1859958..1860920) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /label="yppC gene" promotor_-35 1860088..1860097 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1860109..1860124 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1860109 /Source="Nicolas_upshifts" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1860113..1860448 /Source="Nicolas_S_feature" /locus_tag="new_2339954_2340289" /HighExp="T1.0H, T0.30H, T1.30H, H2O2, Paraq, LBGstat, T2.0H, T-0.40H, Salt, T2.30H" /AntisenseName="yppC" /AntisenseCor="-0.27690969451148201" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S843" promotor_-35 1860419..1860423 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1860439..1860458 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1860450..1860960 /Source="Nicolas_S_feature" /locus_tag="new_2340291_2340801" /HighExp="LBGstat, T1.0H, T1.30H, H2O2, T0.30H, Paraq, T2.0H, C30, G135, G180" /AntisenseName="yppC" /AntisenseCor="-0.312791370178301" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S844" upshifts 1860450 /Source="Nicolas_upshifts" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1860921..1861377) /Source="Nicolas_S_feature" /locus_tag="new_2340762_2341218_c" /HighExp="S8, S6, S7, S5, C30, G135, S4, BT, G180, Fru" /AntisenseName="recU" /AntisenseCor="-0.34780203121991599" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S845" CDS 1860961..1861581 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction resolvase" /protein_id="NP_390112.1" /db_xref="EnsemblGenomes-Gn:BSU22310" /db_xref="EnsemblGenomes-Tr:CAB14147" /db_xref="GOA:P39792" /db_xref="InterPro:IPR004612" /db_xref="InterPro:IPR011335" /db_xref="PDB:1RZN" /db_xref="PDB:1ZP7" /db_xref="PDB:5FDK" /db_xref="SubtiList:BG10953" /db_xref="UniProtKB/Swiss-Prot:P39792" /translation="MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNK YYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEA KETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKE KNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG*" /label="recU CDS" gene 1860961..1861581 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /label="recU gene" promotor_-10 complement(1861366..1861377) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1861377) /Source="Nicolas_upshifts" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1861392..1861398) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1861603..1864347 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /EC_number="2.4.1.129" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan glycosyltransferase (penicillin-binding proteins 1A and 1B)" /protein_id="NP_390113.1" /db_xref="EnsemblGenomes-Gn:BSU22320" /db_xref="EnsemblGenomes-Tr:CAB14148" /db_xref="GOA:P39793" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036116" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10954" /db_xref="UniProtKB/Swiss-Prot:P39793" /translation="MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLIL FVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDE IPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLL SHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDL SKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKV AVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDK LDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTI KPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIP ALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGN NGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVP GVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSL SAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLT EYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQS VDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDK KDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDN NNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN *" /label="ponA CDS" gene 1861603..1864347 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /label="ponA gene" downshifts complement(1864017) /Source="Nicolas_upshifts" /id="D1171" /incds=1 /nref=1 /ntot=77 /MaxReadThrough="1.95969" /MaxDrop="2.87717" /score="24.9960782" /energy="-11.3" /TU="NA" /idTUdmin="U1755" /TUdmin=418 /isTUend="FALSE" /label="downshifts" downshifts 1864333 /Source="Nicolas_upshifts" /id="D1172" /incds=0 /nref=243 /ntot=302 /MaxReadThrough="1.61976" /MaxDrop="7.42523" /score="24.2831363" /energy="-14.6" /TU="U1753" /idTUdmin="U1752" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1864423..1864917) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390114.1" /db_xref="EnsemblGenomes-Gn:BSU22330" /db_xref="EnsemblGenomes-Tr:CAB14149" /db_xref="SubtiList:BG10955" /db_xref="UniProtKB/Swiss-Prot:P39789" /translation="MTQAKEVLASYEQYLRSLGQKSSSDMKKTLQTNPVYFDFCTELQ GDLPWEDSGKYVPLLFEVWDDIKASLLPVFQTRKSRCDQNEMLKGIVCLLASLHWTAG EPVKSLDWQELREKSYPAKPINWAERVEFILLKPTQYHCFIQLDELITEMKKHFYKYH AMNR*" /label="ypoC CDS" gene complement(1864423..1864917) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /label="ypoC gene" downshifts complement(1864436) /Source="Nicolas_upshifts" /id="D1173" /incds=0 /nref=116 /ntot=222 /MaxReadThrough="2.50883" /MaxDrop="5.43593" /score="29.5358766" /energy="-11.6" /TU="NA" /idTUdmin="U1755" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1864914..1865573) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /EC_number="4.2.99.18" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9808040, 11160880, 12682299, 21954439, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9808040, 11160880, 12682299, 21954439, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease III, apurinic apyrimidic DNA lyase" /protein_id="NP_390115.1" /db_xref="EnsemblGenomes-Gn:BSU22340" /db_xref="EnsemblGenomes-Tr:CAB14150" /db_xref="GOA:P39788" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR004035" /db_xref="InterPro:IPR004036" /db_xref="InterPro:IPR005759" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG10956" /db_xref="UniProtKB/Swiss-Prot:P39788" /translation="MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCT DALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYG GEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLE VEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVK R*" /label="nth CDS" gene complement(1864914..1865573) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /label="nth gene" CDS complement(1865592..1866290) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /function="16.9: Replicate" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-remodelling primosomal protein" /protein_id="NP_390116.1" /db_xref="EnsemblGenomes-Gn:BSU22350" /db_xref="EnsemblGenomes-Tr:CAB14151" /db_xref="GOA:P39787" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="PDB:2V79" /db_xref="SubtiList:BG10957" /db_xref="UniProtKB/Swiss-Prot:P39787" /translation="MKKQQFIDMQEQGTSTIPNLLLTHYKQLGLNETELILLLKIKMH LEKGSYFPTPNQLQEGMSISVEECTNRLRMFIQKGFLFIEECEDQNGIKFEKYSLQPL WGKLYEYIQLAQNQTQERKAEGEQKSLYTIFEEEFARPLSPLECETLAIWQDQDQHDA QLIKHALKEAVLSGKLSFRYIDRILFEWKKNGLKTVEQAKIHSQKFRRVQAKQNEPQK EYKRQVPFYNWLEQ*" /label="dnaD CDS" gene complement(1865592..1866290) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /label="dnaD gene" S_feature complement(1866291..1866382) /Source="Nicolas_S_feature" /locus_tag="new_2346132_2346223_c" /HighExp="LoTm, G180, Cold, G135, LBGstat, G150, C30, Etha, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S846" CDS complement(1866383..1867675) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /EC_number="6.1.1.22" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="NP_390117.1" /db_xref="EnsemblGenomes-Gn:BSU22360" /db_xref="EnsemblGenomes-Tr:CAB14152" /db_xref="GOA:P39772" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10958" /db_xref="UniProtKB/Swiss-Prot:P39772" /translation="MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQ GVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYP ITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGS APEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIE FWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPR ITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPAS DREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGS VPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP*" /label="asnS CDS" gene complement(1866383..1867675) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /label="asnS gene" S_feature complement(1867676..1867737) /Source="Nicolas_S_feature" /locus_tag="new_2347517_2347578_c" /HighExp="LBGexp, dia0, Lbexp, G150, G180, LPh, C30, Oxctl, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S847" promotor_-10 complement(1867737..1867756) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1867737) /Source="Nicolas_upshifts" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1867771..1867778) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1867819..1869000) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /EC_number="2.6.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:418816, 12670965, 22740702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 418816, 12670965, 22740702; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anabolic oxaloacetate / glutamate aminotransferase" /protein_id="NP_390118.1" /db_xref="EnsemblGenomes-Gn:BSU22370" /db_xref="EnsemblGenomes-Tr:CAB14153" /db_xref="GOA:P53001" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11513" /db_xref="UniProtKB/Swiss-Prot:P53001" /translation="MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNT PQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHA LYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAI TEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSI AQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQY GAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQS CGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKH S*" /label="aspB CDS" gene complement(1867819..1869000) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /label="aspB gene" downshifts complement(1867823) /Source="Nicolas_upshifts" /id="D1174" /incds=0 /nref=48 /ntot=196 /MaxReadThrough="6.37268" /MaxDrop="4.0831" /score="5.04709675" /energy="-9.3" /TU="U1756,U1758,U1760,U1761,U1762" /idTUdmin="U1760" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1869023..1869508) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /experiment="publication(s) with functional evidences, PMID:25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25954268; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="suppressor of tetracyclin sensitivity of an ezrAmutant" /protein_id="NP_390119.1" /db_xref="EnsemblGenomes-Gn:BSU22380" /db_xref="EnsemblGenomes-Tr:CAB14154" /db_xref="GOA:P54396" /db_xref="InterPro:IPR025711" /db_xref="PDB:2GU3" /db_xref="SubtiList:BG11502" /db_xref="UniProtKB/Swiss-Prot:P54396" /translation="MRKKALIFTVIFGIIFLAVLLVSASIYKSAMAQKEEGHEAAAAE AKKETDLAHVDQVETFVGKEKYYVVKGTDKKGTALYVWVPADKKAKILSKEAKEGISE DKAAKIIKDEGLVSKQKEVHLAREGNVLLWEVTYLDKEGQYSLSYVDFTTGKILKNIT P*" /label="tseB CDS" gene complement(1869023..1869508) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /label="tseB gene" promotor_-10 complement(1869456..1869475) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1869473) /Source="Nicolas_upshifts" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1869488..1869495) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1869517..1869687) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390120.1" /db_xref="EnsemblGenomes-Gn:BSU22390" /db_xref="EnsemblGenomes-Tr:CAB14155" /db_xref="InterPro:IPR012190" /db_xref="SubtiList:BG11501" /db_xref="UniProtKB/Swiss-Prot:P54395" /translation="MESKIEILSTINVEHSDDLYKIVDTLNRTLKRDNLMFGLALDEE NKNQAVFTIYRT*" /label="ypmA CDS" gene complement(1869517..1869687) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /label="ypmA gene" S_feature complement(1869688..1869759) /Source="Nicolas_S_feature" /locus_tag="new_2349529_2349600_c" /HighExp="H2O2, T0.30H, T0.0H, dia15, T-0.40H, T-1.10H, G135, T1.0H, G180, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.136042" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.85, 1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S848" promotor_-35 1869721..1869727 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1869742..1869761) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1869742..1869753 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1869749..1869823 /Source="Nicolas_S_feature" /locus_tag="new_2349590_2349664" /HighExp="S8, S6, S5, S7, nit, BT, G/S, Pyr, C30, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S849" upshifts 1869749 /Source="Nicolas_upshifts" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1869759) /Source="Nicolas_upshifts" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1869761..1869829) /Source="Nicolas_S_feature" /locus_tag="new_2349602_2349670_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, Salt, H2O2, T-1.10H, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S850" promotor_-35 complement(1869777..1869783) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1869793 /Source="Nicolas_upshifts" /id="D1175" /incds=0 /nref=8 /ntot=26 /MaxReadThrough="0.48859" /MaxDrop="6.02806" /score="18.4569945" /energy="-8.4" /TU="NA" /idTUdmin="U1757" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1869830..1872625) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8385320, 12060778, 17416902, 21546913, 22166102, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385320, 12060778, 17416902, 21546913, 22166102, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="damage inducible ATP-dependent 3'->5' nuclease" /protein_id="NP_390121.1" /db_xref="EnsemblGenomes-Gn:BSU22400" /db_xref="EnsemblGenomes-Tr:CAB14156" /db_xref="GOA:P54394" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006310" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11515" /db_xref="UniProtKB/Swiss-Prot:P54394" /translation="MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKY INPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKY ELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTG LIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFS VREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFAN REHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLF PFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNL PSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHK KRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQ RNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKS WSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYC QTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSA TLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQ DTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKL MKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKG KNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSV SEMTDSELEAYVAGEKE*" /label="dinG CDS" gene complement(1869830..1872625) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /label="dinG gene" promotor_-35 1870298..1870302 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1870299 /Source="Nicolas_upshifts" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1870304..1870308 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1870955..1870970) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1870969) /Source="Nicolas_upshifts" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1870983..1870992) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" S_feature complement(1872626..1872750) /Source="Nicolas_S_feature" /locus_tag="new_2352467_2352591_c" /HighExp="dia15, Diami, H2O2, Heat, LBGstat, C30, G180, G135, Oxctl, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S851" CDS complement(1872751..1873134) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /EC_number="4.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9169598, 12600205, 15033515, 26762040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9169598, 12600205, 15033515, 26762040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate 1-decarboxylase" /protein_id="NP_390122.1" /db_xref="EnsemblGenomes-Gn:BSU22410" /db_xref="EnsemblGenomes-Tr:CAB14157" /db_xref="GOA:P52999" /db_xref="InterPro:IPR003190" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG11493" /db_xref="UniProtKB/Swiss-Prot:P52999" /translation="MYRTMMSGKLHRATVTEANLNYVGSITIDEDLIDAVGMLPNEKV QIVNNNNGARLETYIIPGKRGSGVICLNGAAARLVQEGDKVIIISYKMMSDQEAASHE PKVAVLNDQNKIEQMLGNEPARTIL*" /label="panD CDS" gene complement(1872751..1873134) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /label="panD gene" CDS complement(1873136..1873996) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /EC_number="6.3.2.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17175524, 7037743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate synthetase" /protein_id="NP_390123.1" /db_xref="EnsemblGenomes-Gn:BSU22420" /db_xref="EnsemblGenomes-Tr:CAB14158" /db_xref="GOA:P52998" /db_xref="InterPro:IPR003721" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11520" /db_xref="UniProtKB/Swiss-Prot:P52998" /translation="MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKA RQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGE KNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGER DPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNI IIDIREMERI*" /label="panC CDS" gene complement(1873136..1873996) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /label="panC gene" CDS complement(1873998..1874831) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /EC_number="2.1.2.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 8096212; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ketopantoate hydroxymethyltransferase" /protein_id="NP_390124.1" /db_xref="EnsemblGenomes-Gn:BSU22430" /db_xref="EnsemblGenomes-Tr:CAB14159" /db_xref="GOA:P52996" /db_xref="InterPro:IPR003700" /db_xref="InterPro:IPR015813" /db_xref="SubtiList:BG11519" /db_xref="UniProtKB/Swiss-Prot:P52996" /translation="MKTKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDS LGMVVLGLDSTVGVTVADMIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAI VQESGADALKLEGGEGVFESIRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSA KKLIEDSIKCEEAGAMMLVLECVPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDI IGHGVERTPKFVKQYTRIDETIETAISGYVQDVRHRAFPEQKHSFQMNQTVLDGLYGG K*" /label="panB CDS" gene complement(1873998..1874831) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /label="panB gene" S_feature complement(1874832..1875039) /Source="Nicolas_S_feature" /locus_tag="new_2354673_2354880_c" /HighExp="LBGstat, dia15, Diami, H2O2, MG 15, Heat, Oxctl, MG 25, MG 10, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S852" promotor_-10 complement(1875034..1875053) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1875039) /Source="Nicolas_upshifts" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1875070..1875074) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1875077..1876054) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /EC_number="6.3.4.15" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12368242, 15459338, 28466579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 15459338, 28466579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor (BirA-biotinoyl-5'-AMP)" /protein_id="NP_390125.1" /db_xref="EnsemblGenomes-Gn:BSU22440" /db_xref="EnsemblGenomes-Tr:CAB14160" /db_xref="GOA:P0CI75" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="InterPro:IPR004409" /db_xref="InterPro:IPR008988" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR030855" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11206" /db_xref="UniProtKB/Swiss-Prot:P0CI75" /translation="MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEEL RKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHEL ANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAA VAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQ PNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESY ALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG*" /label="birA CDS" gene complement(1875077..1876054) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /label="birA gene" CDS complement(1876039..1877232) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /EC_number="2.7.7.72" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9829937, 16109934, 20360175, 22940585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829937, 16109934, 20360175, 22940585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA nucleotidyltransferase" /protein_id="NP_390126.1" /db_xref="EnsemblGenomes-Gn:BSU22450" /db_xref="EnsemblGenomes-Tr:CAB14161" /db_xref="GOA:P42977" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR023068" /db_xref="InterPro:IPR032810" /db_xref="InterPro:IPR032828" /db_xref="SubtiList:BG11208" /db_xref="UniProtKB/Swiss-Prot:P42977" /translation="MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIA TDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFIS SLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLR AVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQT RLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLP GKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAY QNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLK TCGQH*" /label="cca CDS" gene complement(1876039..1877232) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /label="cca gene" CDS complement(1877237..1878370) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /EC_number="2.4.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751541, 20308541, 22569254, 27454321, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751541, 20308541, 22569254, 27454321, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate synthase;malate glycosyltransferase for bacillithiol synthesis" /protein_id="NP_390127.1" /db_xref="EnsemblGenomes-Gn:BSU22460" /db_xref="EnsemblGenomes-Tr:CAB14162" /db_xref="GOA:P42982" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR023881" /db_xref="InterPro:IPR028098" /db_xref="PDB:5D00" /db_xref="PDB:5D01" /db_xref="SubtiList:BG11213" /db_xref="UniProtKB/Swiss-Prot:P42982" /translation="MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPF RLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVC AYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETY DLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVI RVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLK LLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMS ILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE*" /label="bshA CDS" gene complement(1877237..1878370) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /label="bshA gene" CDS complement(1878367..1879077) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /EC_number="3.5.1.-" /function="4.10: Glutathione and analogs" /experiment="publication(s) with functional evidences, PMID:11004195, 20308541, 23894131, 28117687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004195, 20308541, 23894131, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; malate N-acetylglucosamine N-acetyl hydrolase" /protein_id="NP_390128.2" /db_xref="EnsemblGenomes-Gn:BSU22470" /db_xref="EnsemblGenomes-Tr:CAB14163" /db_xref="GOA:P42981" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023842" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG11212" /db_xref="UniProtKB/Swiss-Prot:P42981" /translation="MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAEL SSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVF MPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFV IDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEG FFSKRMLMLDHDVLGGEQ*" /label="bshBA CDS" gene complement(1878367..1879077) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /label="bshBA gene" CDS complement(1879070..1879483) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /EC_number="4.2.3.3" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="NP_390129.1" /db_xref="EnsemblGenomes-Gn:BSU22480" /db_xref="EnsemblGenomes-Tr:CAB14164" /db_xref="GOA:P42980" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR018148" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG11211" /db_xref="UniProtKB/Swiss-Prot:P42980" /translation="MKIALIAHDKKKQDMVQFTTAYRDILKNHDLYATGTTGLKIHEA TGLQIERFQSGPLGGDQQIGALIAANALDLVIFLRDPLTAQPHEPDVSALIRLCDVYS IPLATNMGTAEILVRTLDEGVFEFRDLLRGEEPNV*" /label="mgsA CDS" gene complement(1879070..1879483) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /label="mgsA gene" CDS complement(1879499..1880302) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /EC_number="1.17.1.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6422596, 9398235, 12682299, 20503968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(4S)-4-hydroxy-2,3,4, 5-tetrahydro-(2S)-dipicolinic acid (HTPA) dehydratase reductase" /protein_id="NP_390130.1" /db_xref="EnsemblGenomes-Gn:BSU22490" /db_xref="EnsemblGenomes-Tr:CAB14165" /db_xref="GOA:P42976" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR022663" /db_xref="InterPro:IPR022664" /db_xref="InterPro:IPR023940" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11207" /db_xref="UniProtKB/Swiss-Prot:P42976" /translation="MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQ KLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTT GFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQK LDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQ EVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID*" /label="dapB CDS" gene complement(1879499..1880302) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /label="dapB gene" CDS complement(1880314..1880649) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16390452, 20529853, 20944217, 21733847, 24339782, 26920050, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidized nucleotide pyrophosphohydrolase" /protein_id="NP_390131.1" /db_xref="EnsemblGenomes-Gn:BSU22500" /db_xref="EnsemblGenomes-Tr:CAB14166" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR012359" /db_xref="PDB:2GTA" /db_xref="SubtiList:BG11210" /db_xref="UniProtKB/Swiss-Prot:P42979" /translation="MSDKTMKDIQAEVDRYIGQFKEGYFSPLAMMARLTEELGELARE VNHRYGEKPKKATEDDKSMEEEIGDVLFVLVCLANSLDISLEEAHDRVMHKFNTRDKD RWTRKEEGK*" /label="ypjD CDS" gene complement(1880314..1880649) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /label="ypjD gene" promotor_-10 complement(1880669..1880688) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1880679) /Source="Nicolas_upshifts" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1880702..1880709) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" promotor_-35 1880718..1880725 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1880734..1880753) /Source="Nicolas_upshift_promotors" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1880739..1880758 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1880745 /Source="Nicolas_upshifts" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1880753) /Source="Nicolas_upshifts" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" CDS 1880789..1881661 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390132.2" /db_xref="EnsemblGenomes-Gn:BSU22510" /db_xref="EnsemblGenomes-Tr:CAB14167" /db_xref="GOA:P42978" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11209" /db_xref="UniProtKB/Swiss-Prot:P42978" /translation="MLGEIRLKNIFFILIGAAIFSFGLVHFNMQNNLAEGGFTGITLL LYALFHISPSISNLVLNIPIFFIGWRLLGRTMFVYTLVGTVALSLFLSIFQRYEIHMP LQHDLALAALFAGVFIGAGLGIIFKFGGTTGGVDIIARLVNKYFGIPMGRTMFAFDAC VIILSLLTYLSYKEAMYTLVAVFVAARLIDFIQEGGYAAKGATIISSKNDLIQKKILE EMERGVTILKGQGSYTKEDIDVLYCVVPKNELVMLKSVINSIDPHAFVAVSDVHDVLG EGFTLDENKNPLPR*" /label="ypjC CDS" gene 1880789..1881661 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /label="ypjC gene" CDS complement(1881703..1882497) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="sporulation septum-associated protein" /protein_id="NP_390133.1" /db_xref="EnsemblGenomes-Gn:BSU22520" /db_xref="EnsemblGenomes-Tr:CAB14168" /db_xref="GOA:P54393" /db_xref="InterPro:IPR014231" /db_xref="SubtiList:BG11500" /db_xref="UniProtKB/Swiss-Prot:P54393" /translation="MKRKLTICLLIALIFYNGNAKAAERGSLEELNDLSDTVFQMTRQ AKYEEALQVLEYFEKTLKSAEKKQQDPMLTGAQIRQITLGYNDMVRSLKQADTSDTQK LRAAAQFRMLMDAVDNRSDPLWGSLEKPIMEAFTELKRDVQKNGSTSFHEKWNEFISL YDLIYPSLTIDVSEDQLETVGKHIDVIEQEEFQQMTESTKLERLSLLQHDLKNVFDRV EEDDADPSLLWVIITTGSIIITALTYVGYRKYKAEKNKLKKRDYPK*" /label="ypjB CDS" gene complement(1881703..1882497) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /label="ypjB gene" downshifts complement(1881728) /Source="Nicolas_upshifts" /id="D1176" /incds=0 /nref=4 /ntot=106 /MaxReadThrough="1.96946" /MaxDrop="3.51024" /score="34.9661402" /energy="-11.3" /TU="NA" /idTUdmin="U1765" /TUdmin=198 /isTUend="FALSE" /label="downshifts" S_feature complement(1882498..1882565) /Source="Nicolas_S_feature" /locus_tag="new_2362339_2362406_c" /HighExp="LBGstat, C30, S0, LoTm, G180, G135, G150, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S853" CDS complement(1882566..1883123) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390134.1" /db_xref="EnsemblGenomes-Gn:BSU22530" /db_xref="EnsemblGenomes-Tr:CAB14169" /db_xref="GOA:P54392" /db_xref="InterPro:IPR009845" /db_xref="SubtiList:BG11499" /db_xref="UniProtKB/Swiss-Prot:P54392" /translation="MLILVLAINFLGTVYGYYWYLPQLLETPARFLIFVPDSPTATFF FLFVLLAFLMKRNAPLLEALALVTLVKYGLWAVAMNFLVLAVTGDLPWEGYMLIASHF AMAVQGVLYSPYFRFSFWHLAIAAVWTLHNDVIDYLFDMMPQYSMLSDYMTEIGYGTF WLSIFSIALAYFLVVSKKQTKLELM*" /label="ypjA CDS" gene complement(1882566..1883123) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /label="ypjA gene" S_feature complement(1883124..1883203) /Source="Nicolas_S_feature" /locus_tag="new_2362965_2363044_c" /HighExp="C30, UNK1, G135, BMM, G150, G180, Oxctl, LoTm, Paraq, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S854" downshifts complement(1883248) /Source="Nicolas_upshifts" /id="D1177" /incds=0 /nref=131 /ntot=215 /MaxReadThrough="3.97061" /MaxDrop="6.41485" /score="13.3880841" /energy="-8" /TU="U1765" /idTUdmin="U1767" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1883270..1884037) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit)" /protein_id="NP_390135.1" /db_xref="EnsemblGenomes-Gn:BSU22540" /db_xref="EnsemblGenomes-Tr:CAB14170" /db_xref="GOA:P46913" /db_xref="InterPro:IPR005798" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012049" /db_xref="InterPro:IPR027387" /db_xref="InterPro:IPR036150" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG11327" /db_xref="UniProtKB/Swiss-Prot:P46913" /translation="MHRGKGMKFVGDSRIPAEKKPNIPKDYSEYPGKTEAFWPNFLLK EWMVGAVFLIGFLVLTIVHQPPLERMADPTDTGYIPLPDWYFLFLYQLLKYEYAAGSF TVVGAMIMPGLAFGALLLAPFLDRGTERRPWKRPVAVGMMLLAISAAVFLTWQSVATH DWAKAEEQGKITKEADIDTNAEGYKVFKEQGCISCHGDNLQGGAAGPSLVDSGLKPDE IKKIAVEGKGKMPAGVFKGNDKQLEELAKFISETTAK*" /label="qcrC CDS" gene complement(1883270..1884037) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /label="qcrC gene" CDS complement(1884072..1884746) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 15849754, 16850406; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)" /protein_id="NP_390136.1" /db_xref="EnsemblGenomes-Gn:BSU22550" /db_xref="EnsemblGenomes-Tr:CAB14171" /db_xref="GOA:P46912" /db_xref="InterPro:IPR005797" /db_xref="InterPro:IPR016174" /db_xref="InterPro:IPR023530" /db_xref="InterPro:IPR027387" /db_xref="SubtiList:BG11326" /db_xref="UniProtKB/Swiss-Prot:P46912" /translation="MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCF GGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVI VMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGL QIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQ GISGPL*" /label="qcrB CDS" gene complement(1884072..1884746) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /label="qcrB gene" CDS complement(1884748..1885251) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /EC_number="1.10.2.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 24652282, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)" /protein_id="NP_390137.1" /db_xref="EnsemblGenomes-Gn:BSU22560" /db_xref="EnsemblGenomes-Tr:CAB14172" /db_xref="GOA:P46911" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR014349" /db_xref="InterPro:IPR014909" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11325" /db_xref="UniProtKB/Swiss-Prot:P46911" /translation="MGGKHDISRRQFLNYTLTGVGGFMAASMLMPMVRFALDPVLKST GKQDMVQVVSVDELTKEPQRFDFKINQVDAWYESEESRSAWVFKNGDEIVALSPICKH LGCTVNWNSDPKNPNKFFCPCHYGLYEKDGTNVPGTPPLAPLDHYEQEVKDGFLYLGK AKPKGEG*" /label="qcrA CDS" gene complement(1884748..1885251) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /label="qcrA gene" downshifts 1885260 /Source="Nicolas_upshifts" /id="D1178" /incds=0 /nref=1 /ntot=80 /MaxReadThrough="1.24169" /MaxDrop="3.42621" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=3608 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1885315..1885334) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1885315) /Source="Nicolas_upshifts" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1885349..1885356) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1885394..1885840) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15743949" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390138.1" /db_xref="EnsemblGenomes-Gn:BSU22570" /db_xref="EnsemblGenomes-Tr:CAB14173" /db_xref="InterPro:IPR019615" /db_xref="SubtiList:BG11498" /db_xref="UniProtKB/Swiss-Prot:P54391" /translation="MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFT QLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWR AEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL*" /label="ypiF CDS" gene complement(1885394..1885840) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /label="ypiF gene" downshifts 1885843 /Source="Nicolas_upshifts" /id="D1179" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="0.94679" /MaxDrop="2.794" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=4191 /isTUend="FALSE" /label="downshifts" CDS complement(1885895..1886434) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16847875" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390139.1" /db_xref="EnsemblGenomes-Gn:BSU22580" /db_xref="EnsemblGenomes-Tr:CAB14174" /db_xref="InterPro:IPR011188" /db_xref="InterPro:IPR014957" /db_xref="InterPro:IPR014963" /db_xref="SubtiList:BG11497" /db_xref="UniProtKB/Swiss-Prot:P54390" /translation="MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEK VHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLN FRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDAL DRHDKEAFEQLSRQLNQLT*" /label="ypiB CDS" gene complement(1885895..1886434) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /label="ypiB gene" downshifts complement(1885908) /Source="Nicolas_upshifts" /id="D1180" /incds=0 /nref=84 /ntot=250 /MaxReadThrough="5.68366" /MaxDrop="5.48142" /score="16.8021869" /energy="-11.2" /TU="U1766,U1767" /idTUdmin="U1768" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1886467..1886485) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1886478) /Source="Nicolas_upshifts" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="upshifts" promotor_-35 complement(1886497..1886505) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" CDS complement(1886506..1887777) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390140.1" /db_xref="EnsemblGenomes-Gn:BSU22590" /db_xref="EnsemblGenomes-Tr:CAB14175" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11496" /db_xref="UniProtKB/Swiss-Prot:P54389" /translation="MNTLIQEAIKLVEAGETEKGLNTLSKAEKQLHDEDKAIAAQLYY EWGDVEKAISLISDLHDLYPNETELTNFYAELLIDIDEEEKALAVLETIPETDPSYPE SLLLMADLYQMQGLFEVSEQKLFQAKSILDNEPVIDFALGELYFAQGAYAKAVQYFKT TAEEQSEIGGVNVHQRLAESLSASGEFEDAIPWYEKAVDENPDPNTIFGYGFTALQAG LVKTAIKQLSDLKELDPSYTSLYMPLSKSYEAEGMYEEALKTAKEGIRYDEYNKELFL YAAKMALKIGKSEEGKKLLQEALALDPGFVEALHTLLAVYHKEEDYDQIIDLIQEVRS YGEEDPKYNWYLASAYTELEQYEEAKQSFEAAYLHYREDRDFLYEYASFLLEEGLQKE ALPLLKKVLEMDGANEELEETILRIEDEFSR*" /label="ypiA CDS" gene complement(1886506..1887777) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /label="ypiA gene" S_feature complement(1887778..1887845) /Source="Nicolas_S_feature" /locus_tag="new_2367619_2367686_c" /HighExp="dia15, Diami, dia5, Etha, H2O2, T1.30H, LPhT, T0.30H, T3.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF, SigA" /TUshortPSig="0.999, 0.999, 0.999, 1" /TUlongSig="Sig-, Sig-, SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.047, 0.994, 0.999, 1, 0.999, 1, 0.998" /label="S855" promotor_-10 complement(1887842..1887861) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1887845) /Source="Nicolas_upshifts" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1887875..1887882) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1887912..1887931) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1887918) /Source="Nicolas_upshifts" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="upshifts" S_feature complement(1887920..1888064) /Source="Nicolas_S_feature" /locus_tag="new_2367761_2367905_c" /HighExp="S3, LoTm, M9-stat, S4, Etha, S5, T5.0H, BT, B36, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.047, 0.994" /TUlongSig="Sig-, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.999, 1, 0.999, 1, 0.998" /label="S856" promotor_-35 complement(1887942..1887949) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" promotor_-10 complement(1888046..1888064) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1888064) /Source="Nicolas_upshifts" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1888080..1888085) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1888113..1889399) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /EC_number="2.5.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3106153, 22938038, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvoylshikimate-3-phosphate synthase)" /protein_id="NP_390141.1" /db_xref="EnsemblGenomes-Gn:BSU22600" /db_xref="EnsemblGenomes-Tr:CAB14176" /db_xref="GOA:P20691" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR023193" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10294" /db_xref="UniProtKB/Swiss-Prot:P20691" /translation="MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPG ADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILA GRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQ KLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEI KPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAA ELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLG IASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS*" /label="aroA CDS" gene complement(1888113..1889399) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /label="aroA gene" downshifts complement(1888136) /Source="Nicolas_upshifts" /id="D1181" /incds=0 /nref=68 /ntot=212 /MaxReadThrough="3.64462" /MaxDrop="4.25336" /score="16.8021869" /energy="-11.2" /TU="U1770,U1772,U1773" /idTUdmin="U1775" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1889410..1890525) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /EC_number="1.3.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106153, 3121591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106153, 3121591; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydrogenase" /protein_id="NP_390142.1" /db_xref="EnsemblGenomes-Gn:BSU22610" /db_xref="EnsemblGenomes-Tr:CAB14177" /db_xref="GOA:P20692" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003099" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10293" /db_xref="UniProtKB/Swiss-Prot:P20692" /translation="MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAV AALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGST KQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAV EQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFA AGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRY FKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIET REDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD*" /label="tyrA CDS" gene complement(1889410..1890525) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /label="tyrA gene" CDS complement(1890574..1891656) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /EC_number="2.6.1.5" /EC_number="2.6.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4431, 418816, 824269, 11518529, 15102328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4431, 418816, 824269, 11518529, 15102328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous)" /protein_id="NP_390143.2" /db_xref="EnsemblGenomes-Gn:BSU22620" /db_xref="EnsemblGenomes-Tr:CAB14178" /db_xref="GOA:P17731" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR005861" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10292" /db_xref="UniProtKB/Swiss-Prot:P17731" /translation="MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCS EAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFL NDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMIL RTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCV EQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALG FPTSLRITIGTKEQNEEILAILAEIL*" /label="hisC CDS" gene complement(1890574..1891656) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /label="hisC gene" CDS complement(1891667..1892470) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (alpha subunit)" /protein_id="NP_390144.1" /db_xref="EnsemblGenomes-Gn:BSU22630" /db_xref="EnsemblGenomes-Tr:CAB14179" /db_xref="GOA:P07601" /db_xref="InterPro:IPR002028" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018204" /db_xref="SubtiList:BG10291" /db_xref="UniProtKB/Swiss-Prot:P07601" /translation="MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALEL GVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQ LNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTII EQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNE ISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK*" /label="trpA CDS" gene complement(1891667..1892470) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /label="trpA gene" promotor_-10 complement(1892155..1892174) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1892172) /Source="Nicolas_upshifts" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1892186..1892193) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1892463..1893665) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (beta subunit)" /protein_id="NP_390145.2" /db_xref="EnsemblGenomes-Gn:BSU22640" /db_xref="EnsemblGenomes-Tr:CAB14180" /db_xref="GOA:P07600" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /db_xref="InterPro:IPR023026" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10290" /db_xref="UniProtKB/Swiss-Prot:P07600" /translation="MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFR EEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAK KMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVV PVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQ LKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKG TVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEA VDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVL EEEVKAHV*" /label="trpB CDS" gene complement(1892463..1893665) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /label="trpB gene" CDS complement(1893646..1894293) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /EC_number="5.3.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylanthranilate isomerase" /protein_id="NP_390146.3" /db_xref="EnsemblGenomes-Gn:BSU22650" /db_xref="EnsemblGenomes-Tr:CAB14181" /db_xref="GOA:P20167" /db_xref="InterPro:IPR001240" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10289" /db_xref="UniProtKB/Swiss-Prot:P20167" /translation="MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDV KKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCE IWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKR CFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE*" /label="trpF CDS" gene complement(1893646..1894293) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /label="trpF gene" downshifts complement(1893740) /Source="Nicolas_upshifts" /id="D1182" /incds=1 /nref=30 /ntot=83 /MaxReadThrough="8.17917" /MaxDrop="5.75867" /score="2.96963632" /energy="-11.9" /TU="U1771,U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=616 /isTUend="FALSE" /label="downshifts" misc_feature complement(1893916..1893919) /Source="Nicolas_upshift_promotors" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1893916) /Source="Nicolas_upshifts" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" downshifts complement(1894136) /Source="Nicolas_upshifts" /id="D1183" /incds=1 /nref=1 /ntot=84 /MaxReadThrough="8.55417" /MaxDrop="3.4408" /score="2.96963632" /energy="-11.9" /TU="U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=220 /isTUend="FALSE" /label="downshifts" misc_feature 1894298..1895050 /created_by="AR/SM" /id="IIG_Bs01" /note="due to the curing of the trpC2 locus (auxotrophy) of the Delta6 strain by transformation with chromosomal DNA from donor Bsu 3NA multiple snp`s were transferred to the oroginal trpC locus" /modified_by="User" /label="IIG_Bs01" /note="Geneious type: MiniBacillus__exchange" CDS complement(1894298..1895050) /locus_tag="PG10_trpC_var_BEP06_07765" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_007409461.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="indole-3-glycerol phosphate synthase" /protein_id="ANY35339.1" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /translation="MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASLNRFIGLIA EVKKASPSKGLIKENFVPVRIAKDYETAKADALSVLTDTPFFQGENSYLSDVKRAVSI PVLRKDFIIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKEMDVLVEVHDA TTLEQILKVFTPDILGINNRNLKTFETSIMQTEQIASLAPKESLLVSESGIGSLEHLT FVKEHGARAVLIGESLMRQTSQRKAIHALFRE*" /label="PG10_trpC_var_BEP06_07765" gene complement(1894298..1895050) /locus_tag="PG10_trpC_var_BEP06_07765" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /label="PG10_trpC_var_BEP06_07765" misc_feature complement(1894331..1894333) /Source="Nicolas_upshift_promotors" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1894334 /Source="Nicolas_upshifts" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" Polymorphism join(1894440,1894443) /Source="geneious" /ID="SNP_BsPG10_2374282_2374283" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change /CDS_Position=606 /Change="AG -> GT" /Codon_Change="TCC,TTG -> TCA,CTG" /Coverage="129 -> 130" /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="AG" /Variant_Nucleotides="GT" /Variant_P_Value="2e-203" /Variant_Raw_Frequency="128 -> 129" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894454,1894456) /Source="geneious" /ID="SNP_BsPG10_2374296_2374296" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> A" /CDS_Position=593 /Change="A -> G" /Codon_Change="GTT -> GCT" /Coverage=119 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.2e-179" /Variant_Raw_Frequency=119 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894456,1894458) /Source="geneious" /ID="SNP_BsPG10_2374298_2374298" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=591 /Change="G -> A" /Codon_Change="CTC -> CTT" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="9.9e-148" /Variant_Raw_Frequency=116 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894481,1894483) /Source="geneious" /ID="SNP_BsPG10_2374323_2374323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="K -> M" /CDS_Position=566 /Change="T -> A" /Codon_Change="AAG -> ATG" /Coverage=81 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="A" /Variant_P_Value="6.3e-98" /Variant_Raw_Frequency=81 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894483,1894487) /Source="geneious" /ID="SNP_BsPG10_2374325_2374327" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="V -> I" /CDS_Position=562 /Change="TAC -> GAT" /Codon_Change="GTA -> ATC" /Coverage="79 -> 84" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="TAC" /Variant_Nucleotides="GAT" /Variant_P_Value="2.3e-77" /Variant_Raw_Frequency="74 -> 78" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894489,1894491) /Source="geneious" /ID="SNP_BsPG10_2374331_2374331" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=558 /Change="T -> G" /Codon_Change="ACA -> ACC" /Coverage=70 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="1e-63" /Variant_Raw_Frequency=70 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894498,1894500) /Source="geneious" /ID="SNP_BsPG10_2374340_2374340" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=549 /Change="C -> A" /Codon_Change="ACG -> ACT" /Coverage=59 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="A" /Variant_P_Value="1e-59" /Variant_Raw_Frequency=59 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894513,1894515) /Source="geneious" /ID="SNP_BsPG10_2374355_2374355" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=534 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=66 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="6e-64" /Variant_Raw_Frequency=65 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894516,1894518) /Source="geneious" /ID="SNP_BsPG10_2374358_2374358" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=531 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=63 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.3e-68" /Variant_Raw_Frequency=60 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894521,1894523) /Source="geneious" /ID="SNP_BsPG10_2374363_2374363" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> I" /CDS_Position=526 /Change="C -> T" /Codon_Change="GTA -> ATA" /Coverage=65 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="3.9e-82" /Variant_Raw_Frequency=64 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894531,1894533) /Source="geneious" /ID="SNP_BsPG10_2374373_2374373" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=516 /Change="G -> A" /Codon_Change="GAC -> GAT" /Coverage=79 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="7.7e-116" /Variant_Raw_Frequency=78 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894534,1894536) /Source="geneious" /ID="SNP_BsPG10_2374376_2374376" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=513 /Change="G -> A" /Codon_Change="CCC -> CCT" /Coverage=92 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="4e-141" /Variant_Raw_Frequency=90 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894537,1894539) /Source="geneious" /ID="SNP_BsPG10_2374379_2374379" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=510 /Change="T -> C" /Codon_Change="ACA -> ACG" /Coverage=97 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.3e-165" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894543,1894545) /Source="geneious" /ID="SNP_BsPG10_2374385_2374385" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=504 /Change="C -> T" /Codon_Change="GTG -> GTA" /Coverage=109 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="4.3e-193" /Variant_Raw_Frequency=108 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894569,1894571) /Source="geneious" /ID="SNP_BsPG10_2374411_2374411" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="S -> T" /CDS_Position=478 /Change="A -> T" /Codon_Change="TCA -> ACA" /Coverage=148 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value="2.9e-307" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894601,1894603) /Source="geneious" /ID="SNP_BsPG10_2374443_2374443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="G -> E" /CDS_Position=446 /Change="C -> T" /Codon_Change="GGG -> GAG" /Coverage=161 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=161 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894654,1894656) /Source="geneious" /ID="SNP_BsPG10_2374496_2374496" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=393 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=174 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894702,1894704) /Source="geneious" /ID="SNP_BsPG10_2374544_2374544" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=345 /Change="T -> C" /Codon_Change="GTA -> GTG" /Coverage=168 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=167 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894717,1894721) /Source="geneious" /ID="SNP_BsPG10_2374559_2374558" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=0 /Amino_Acid_Change="-> I" /CDS_Position=331 /Change="AAT" /Codon_Change="-> ATT" /Coverage=164 /locus_tag="BSU_22660" /Protein_Effect="Insertion" /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="AAT" /Variant_P_Value="3.90000001038273e-316" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894735,1894737) /Source="geneious" /ID="SNP_BsPG10_2374574_2374574" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=315 /Change="A -> G" /Codon_Change="CTT -> CTC" /Coverage=155 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894744,1894746) /Source="geneious" /ID="SNP_BsPG10_2374583_2374583" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=306 /Change="A -> T" /Codon_Change="ATT -> ATA" /Coverage=153 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=152 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894756,1894758) /Source="geneious" /ID="SNP_BsPG10_2374595_2374595" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=294 /Change="A -> G" /Codon_Change="CGT -> CGC" /Coverage=128 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="4e-295" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894821,1894823) /Source="geneious" /ID="SNP_BsPG10_2374660_2374660" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="I -> L" /CDS_Position=229 /Change="T -> G" /Codon_Change="ATT -> CTT" /Coverage=131 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="2.3e-302" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894831,1894833) /Source="geneious" /ID="SNP_BsPG10_2374670_2374670" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=219 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=126 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="1.6e-290" /Variant_Raw_Frequency=126 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894839,1894842) /Source="geneious" /ID="SNP_BsPG10_2374678_2374679" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="EA -> ET" /CDS_Position=210 /Change="CC -> TT" /Codon_Change="GAG,GCT -> GAA,ACT" /Coverage="124 -> 130" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="CC" /Variant_Nucleotides="TT" /Variant_P_Value="4.7e-253" /Variant_Raw_Frequency="119 -> 125" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894859,1894861) /Source="geneious" /ID="SNP_BsPG10_2374698_2374698" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="Q -> R" /CDS_Position=191 /Change="T -> C" /Codon_Change="CAG -> CGG" /Coverage=104 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="9e-228" /Variant_Raw_Frequency=101 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894875,1894877) /Source="geneious" /ID="SNP_BsPG10_2374714_2374714" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="D -> N" /CDS_Position=175 /Change="C -> T" /Codon_Change="GAT -> AAT" /Coverage=95 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency="1.1%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="2.8e-220" /Variant_Raw_Frequency=93 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894903,1894905) /Source="geneious" /ID="SNP_BsPG10_2374742_2374742" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=147 /Change="T -> C" /Codon_Change="GCA -> GCG" /Coverage=98 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.2e-260" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894918,1894920) /Source="geneious" /ID="SNP_BsPG10_2374757_2374757" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=132 /Change="G -> A" /Codon_Change="GCC -> GCT" /Coverage=197 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value /Variant_Raw_Frequency /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894943,1894945) /Source="geneious" /ID="SNP_BsPG10_2374782_2374782" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="P -> L" /CDS_Position=107 /Change="G -> A" /Codon_Change="CCG -> CTG" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value=0 /Variant_Raw_Frequency=118 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894960,1894962) /Source="geneious" /ID="SNP_BsPG10_2374799_2374799" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=90 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=133 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=131 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1894975,1894977) /Source="geneious" /ID="SNP_BsPG10_2374814_2374814" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=75 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=130 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=130 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" CDS complement(1895043..1896059) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /EC_number="2.4.2.18" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 17114058; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="anthranilate phosphoribosyltransferase" /protein_id="NP_390148.2" /db_xref="EnsemblGenomes-Gn:BSU22670" /db_xref="EnsemblGenomes-Tr:CAB14183" /db_xref="GOA:P03947" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR005940" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="SubtiList:BG10288" /db_xref="UniProtKB/Swiss-Prot:P03947" /modified_by="User" /translation="MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILA HRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGA KIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSS RDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNI FENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEE EIYA*" /label="trpD CDS" gene complement(1895043..1896059) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /modified_by="User" /label="trpD gene" CDS complement(1896031..1897578) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anthranilate synthase" /protein_id="NP_390149.1" /db_xref="EnsemblGenomes-Gn:BSU22680" /db_xref="EnsemblGenomes-Tr:CAB14184" /db_xref="GOA:P03963" /db_xref="InterPro:IPR005256" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10287" /db_xref="UniProtKB/Swiss-Prot:P03963" /translation="MNFQSNISAFLEDSLSHHTIPIVETFTVDTLTPIQMIEKLDREI TYLLESKDDTSTWSRYSFIGLNPFLTIKEEQGRFSAADQDSKSLYTGNELKEVLNWMN TTYKIKTPELGIPFVGGAVGYLSYDMIPLIEPSVPSHTKETDMEKCMLFVCRTLIAYD HETKNVHFIQYARLTGEETKNEKMDVFHQNHLELQNLIEKMMDQKNIKELFLSADSYK TPSFETVSSNYEKSAFMADVEKIKSYIKAGDIFQGVLSQKFEVPIKADAFELYRVLRI VNPSPYMYYMKLLDREIVGSSPERLIHVQDGHLEIHPIAGTRKRGADKAEDERLKVEL MKDEKEKAEHYMLVDLARNDIGRVAEYGSVSVPEFTKIVSFSHVMHIISVVTGRLKKG VHPVDALMSAFPAGTLTGAPKIRAMQLLQELEPTPRETYGGCIAYIGFDGNIDSCITI RTMSVKNGVASIQAGAGIVADSVPEAEYEESCNKAGALLKTIHIAEDMFHSKEDKADE QISTIVR*" /label="trpE CDS" gene complement(1896031..1897578) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /label="trpE gene" S_feature complement(1897657..1897788) /Source="Nicolas_S_feature" /locus_tag="new_2377495_2377626_c" /HighExp="Etha, S1, GM 25, GM 15, HiTm, Glu, MG-0.1, GM 60, M9-exp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.994, 0.647, 0.999, 1, 0.996" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.998" /label="S857" downshifts complement(1897700) /Source="Nicolas_upshifts" /id="D1184" /incds=0 /nref=61 /ntot=157 /MaxReadThrough="7.41666" /MaxDrop="5.25158" /score="2.96963632" /energy="-11.9" /TU="U1773,U1774,U1775,U1776" /idTUdmin="U1777" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1897779..1897798) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-10" upshifts complement(1897788) /Source="Nicolas_upshifts" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" CDS complement(1897794..1898177) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate mutase" /protein_id="NP_390150.1" /db_xref="EnsemblGenomes-Gn:BSU22690" /db_xref="EnsemblGenomes-Tr:CAB14185" /db_xref="GOA:P19080" /db_xref="InterPro:IPR008243" /db_xref="InterPro:IPR035959" /db_xref="PDB:1COM" /db_xref="PDB:1DBF" /db_xref="PDB:1FNJ" /db_xref="PDB:1FNK" /db_xref="PDB:2CHS" /db_xref="PDB:2CHT" /db_xref="PDB:3ZO8" /db_xref="PDB:3ZOP" /db_xref="PDB:3ZP4" /db_xref="PDB:3ZP7" /db_xref="SubtiList:BG10286" /db_xref="UniProtKB/Swiss-Prot:P19080" /translation="MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQ MLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQD QIRHVYLEKVVVLRPDLSLTKNTEL*" /label="aroH CDS" gene complement(1897794..1898177) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /label="aroH gene" promotor_-35 complement(1897813..1897820) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-35" CDS complement(1898174..1899262) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /EC_number="4.2.3.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate synthase" /protein_id="NP_390151.1" /db_xref="EnsemblGenomes-Gn:BSU22700" /db_xref="EnsemblGenomes-Tr:CAB14186" /db_xref="GOA:P31102" /db_xref="InterPro:IPR016037" /db_xref="InterPro:IPR030960" /db_xref="InterPro:IPR030963" /db_xref="SubtiList:BG10285" /db_xref="UniProtKB/Swiss-Prot:P31102" /translation="MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTD EEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIA FGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMI FKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLN ELGKVADHTFSRNELESWLNKWRLEETS*" /label="aroB CDS" gene complement(1898174..1899262) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /label="aroB gene" promotor_-10 complement(1898303..1898318) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1898316) /Source="Nicolas_upshifts" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1898331..1898339) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1899262..1900434) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /EC_number="4.2.3.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 10518299, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 10518299, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate synthase" /protein_id="NP_390152.3" /db_xref="EnsemblGenomes-Gn:BSU22710" /db_xref="EnsemblGenomes-Tr:CAB14187" /db_xref="GOA:P31104" /db_xref="InterPro:IPR000453" /db_xref="InterPro:IPR020541" /db_xref="InterPro:IPR035904" /db_xref="SubtiList:BG10284" /db_xref="UniProtKB/Swiss-Prot:P31104" /translation="MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHG RGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMK RQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVA GHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGG IVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHD EIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFS ASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF*" /label="aroF CDS" gene complement(1899262..1900434) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /label="aroF gene" promotor_-10 complement(1900469..1900488) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1900486) /Source="Nicolas_upshifts" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1900501..1900508) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1900509..1901279) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /EC_number="2.1.1.80" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCPs) methyltransferase" /protein_id="NP_390153.2" /db_xref="EnsemblGenomes-Gn:BSU22720" /db_xref="EnsemblGenomes-Tr:CAB14188" /db_xref="GOA:P31105" /db_xref="InterPro:IPR000780" /db_xref="InterPro:IPR022641" /db_xref="InterPro:IPR022642" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036804" /db_xref="PDB:5FTW" /db_xref="SubtiList:BG10283" /db_xref="UniProtKB/Swiss-Prot:P31105" /translation="MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFK DFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAAC STGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRY FTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLK MAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR*" /label="cheR CDS" gene complement(1900509..1901279) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /label="cheR gene" promotor_-10 complement(1901305..1901324) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1901322) /Source="Nicolas_upshifts" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1901336..1901342) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" S_feature complement(1901354..1901515) /Source="Nicolas_S_feature" /locus_tag="new_2381192_2381353_c" /HighExp="M0t90, Lbstat, S0, Mt0, M0t45, M40t90, Lbtran, Mal, G/S, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.996, 0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S858" downshifts complement(1901397) /Source="Nicolas_upshifts" /id="D1185" /incds=0 /nref=26 /ntot=128 /MaxReadThrough="4.04342" /MaxDrop="4.7493" /score="29.2259705" /energy="-8.6" /TU="U1777,U1778,U1779,U1780" /idTUdmin="U1778" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" CDS complement(1901516..1901965) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /EC_number="2.7.4.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 11734624, 22720735, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside diphosphate kinase" /protein_id="NP_390154.1" /db_xref="EnsemblGenomes-Gn:BSU22730" /db_xref="EnsemblGenomes-Tr:CAB14189" /db_xref="GOA:P31103" /db_xref="InterPro:IPR001564" /db_xref="InterPro:IPR023005" /db_xref="InterPro:IPR034907" /db_xref="InterPro:IPR036850" /db_xref="SubtiList:BG10282" /db_xref="UniProtKB/Swiss-Prot:P31103" /translation="MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQ MAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTI RGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY*" /label="ndk CDS" gene complement(1901516..1901965) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /label="ndk gene" promotor_-10 complement(1902008..1902027) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1902015) /Source="Nicolas_upshifts" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1902040..1902047) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1902081..1903127) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /EC_number="2.5.1.30" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component II" /protein_id="NP_390155.1" /db_xref="EnsemblGenomes-Gn:BSU22740" /db_xref="EnsemblGenomes-Tr:CAB14190" /db_xref="GOA:P31114" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR014119" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG10281" /db_xref="UniProtKB/Swiss-Prot:P31114" /translation="MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDV IERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLE MIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAH RILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADE KIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPA LKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARS SLAAIAKYIGKRKF*" /label="hepT CDS" gene complement(1902081..1903127) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /label="hepT gene" CDS complement(1903069..1903770) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /EC_number="2.1.1.163" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16279806, 9045837, 9139683, 21513522, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16279806, 9045837, 9139683, 21513522, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="demethylmenaquinone methyltransferase" /protein_id="NP_390156.1" /db_xref="EnsemblGenomes-Gn:BSU22750" /db_xref="EnsemblGenomes-Tr:CAB14191" /db_xref="GOA:P31113" /db_xref="InterPro:IPR004033" /db_xref="InterPro:IPR014122" /db_xref="InterPro:IPR023576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10280" /db_xref="UniProtKB/Swiss-Prot:P31113" /translation="MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMN VKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIEL LHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF GFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKY HSFTGGVAATHIGWK*" /label="menG CDS" gene complement(1903069..1903770) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /label="menG gene" CDS complement(1903777..1904532) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /EC_number="2.5.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component I" /protein_id="NP_390157.1" /db_xref="EnsemblGenomes-Gn:BSU22760" /db_xref="EnsemblGenomes-Tr:CAB14192" /db_xref="GOA:P31112" /db_xref="InterPro:IPR009920" /db_xref="SubtiList:BG10279" /db_xref="UniProtKB/Swiss-Prot:P31112" /translation="MQDIYGTLANLNTKLKQKLSHPYLAKHISAPKIDEDKLLLFHAL FEEADIKNNDRENYIVTAMLVQSALDTHDEVTTARVIKRDENKNRQLTVLAGDYFSGL YYSLLSEMKDIYMIRTLATAIKEINEHKIRLYDRSFKDENDFFESVGIVESALFHRVA EHFNLPRWKKLSSDFFVFKRLMNGNDAFLDVIGSFIQLGKTKEEILEDCFKKAKNSIE SLLPLNSPIQNILINRLKTISQDQTYHQKVEEG*" /label="hepS CDS" gene complement(1903777..1904532) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /label="hepS gene" S_feature complement(1904533..1904618) /Source="Nicolas_S_feature" /locus_tag="new_2384371_2384456_c" /HighExp="H2O2, G150, G180, Paraq, Oxctl, G135, T-4.40H, Lbexp, T-3.40H, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S859" promotor_-10 complement(1904607..1904626) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1904618) /Source="Nicolas_upshifts" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1904637..1904644) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1904696..1904923) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15099736, 15588817, 16285852, 16306262, 17114058, 28069823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15099736, 15588817, 16285852, 16306262, 17114058, 28069823; Product type r : regulator" /codon_start=1 /transl_table=11 /product="tryptophan operon RNA-binding attenuation protein (TRAP)" /protein_id="NP_390158.1" /db_xref="EnsemblGenomes-Gn:BSU22770" /db_xref="EnsemblGenomes-Tr:CAB14193" /db_xref="GOA:P19466" /db_xref="InterPro:IPR000824" /db_xref="InterPro:IPR016031" /db_xref="InterPro:IPR023558" /db_xref="PDB:1WAP" /db_xref="PDB:3ZZQ" /db_xref="PDB:4B27" /db_xref="SubtiList:BG10278" /db_xref="UniProtKB/Swiss-Prot:P19466" /translation="MNQKHSSDFVVIKAVEDGVNVIGLTRGTDTKFHHSEKLDKGEVI IAQFTEHTSAIKVRGEALIQTAYGEMKSEKK*" /label="mtrB CDS" gene complement(1904696..1904923) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /label="mtrB gene" downshifts complement(1904717) /Source="Nicolas_upshifts" /id="D1186" /incds=0 /nref=22 /ntot=162 /MaxReadThrough="6.02348" /MaxDrop="4.385" /score="8.50521108" /energy="-10.5" /TU="U1779,U1780" /idTUdmin="U1781" /TUdmin=1499 /isTUend="FALSE" /label="downshifts" CDS complement(1904945..1905517) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1551827, 12559918, 14717702, 17032654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1551827, 12559918, 14717702, 17032654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_390159.1" /db_xref="EnsemblGenomes-Gn:BSU22780" /db_xref="EnsemblGenomes-Tr:CAB14194" /db_xref="GOA:P19465" /db_xref="InterPro:IPR001474" /db_xref="InterPro:IPR018234" /db_xref="InterPro:IPR020602" /db_xref="SubtiList:BG10277" /db_xref="UniProtKB/Swiss-Prot:P19465" /translation="MKEVNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVF SGLNEDPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTG LSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG AKTVTSAVRGVFKDDAAARAEVLEHIKRQD*" /label="folEA CDS" gene complement(1904945..1905517) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /label="folEA gene" promotor_-10 complement(1905546..1905565) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1905556) /Source="Nicolas_upshifts" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" S_feature complement(1905558..1905641) /Source="Nicolas_S_feature" /locus_tag="new_2385396_2385479_c" /HighExp="Oxctl, G150, G180, G135, LBGexp, Paraq, LPh, H2O2, aero, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S860" promotor_-35 complement(1905578..1905584) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" downshifts complement(1905686) /Source="Nicolas_upshifts" /id="D1187" /incds=0 /nref=33 /ntot=254 /MaxReadThrough="6.68474" /MaxDrop="5.1938" /score="8.50521108" /energy="-10.5" /TU="U1780" /idTUdmin="U1781" /TUdmin=530 /isTUend="FALSE" /label="downshifts" CDS complement(1905705..1905983) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /function="16.1: Circulate" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617; Product type f: factor" /codon_start=1 /transl_table=11 /product="non-specific DNA-binding protein HBsu" /protein_id="NP_390160.1" /db_xref="EnsemblGenomes-Gn:BSU22790" /db_xref="EnsemblGenomes-Tr:CAB14195" /db_xref="GOA:P08821" /db_xref="InterPro:IPR000119" /db_xref="InterPro:IPR010992" /db_xref="InterPro:IPR020816" /db_xref="SubtiList:BG10276" /db_xref="UniProtKB/Swiss-Prot:P08821" /translation="MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQL IGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK*" /label="hbs CDS" gene complement(1905705..1905983) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /label="hbs gene" S_feature complement(1905984..1906209) /Source="Nicolas_S_feature" /locus_tag="new_2385822_2386047_c" /HighExp="dia5, C90, T-0.40H, G/S, S1, Salt, Lbexp, dia15, T-1.40H, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S861" promotor_-10 complement(1906191..1906210) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1906209) /Source="Nicolas_upshifts" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1906227..1906232) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1906357..1907835) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11160095, 17114257, 17427285, 24810258, 26387458, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160095, 17114257, 17427285, 24810258, 26387458, 28408070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="morphogenetic stage IV sporulation protein" /protein_id="NP_390161.1" /db_xref="EnsemblGenomes-Gn:BSU22800" /db_xref="EnsemblGenomes-Tr:CAB14196" /db_xref="GOA:P35149" /db_xref="InterPro:IPR014201" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10275" /db_xref="UniProtKB/Swiss-Prot:P35149" /translation="MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLP NISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYT VPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDI ARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVE SMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRL RDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRD HLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVR LKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLS SIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL*" /label="spoIVA CDS" gene complement(1906357..1907835) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /label="spoIVA gene" downshifts complement(1906370) /Source="Nicolas_upshifts" /id="D1188" /incds=0 /nref=59 /ntot=76 /MaxReadThrough="3.43222" /MaxDrop="7.13908" /score="13.6316529" /energy="-9.2" /TU="U1781" /idTUdmin="U1782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1907836..1907997) /Source="Nicolas_S_feature" /locus_tag="new_2387674_2387835_c" /HighExp="S3, S4, S5, S6, LoTm, S7, B36, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S862" promotor_-10 complement(1907984..1908002) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-10" upshifts complement(1908009) /Source="Nicolas_upshifts" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="upshifts" CDS complement(1908016..1908750) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein of unknown function" /protein_id="NP_390162.1" /db_xref="EnsemblGenomes-Gn:BSU22810" /db_xref="EnsemblGenomes-Tr:CAB14197" /db_xref="SubtiList:BG10274" /db_xref="UniProtKB/Swiss-Prot:P39911" /translation="MGKLKCAIIFAAVVFLSGCLYPNERKSSVHAIPYQDQLKQVQSA VDEFQKANGGLLPIQTKDMSTPLYQKYPIDFNRLAPRYIAEPPSTAFESGGDYQYVLV DVENDPTVKLIDLKMAEKIRDVKLRIQMYRQEHQYPPYKDVLSRDLFTLDEKKLGDGS SLTVTSPISGNSLPLMIDGDGEIYADYRTELASCLKKSKKTFKPGTEIQDMIWHETPF VPAFSVKYTVNDKQEPVFLENDMKKE*" /label="yphF CDS" gene complement(1908016..1908750) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /label="yphF gene" promotor_-35 complement(1908017..1908022) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-35" downshifts complement(1908042) /Source="Nicolas_upshifts" /id="D1189" /incds=0 /nref=6 /ntot=78 /MaxReadThrough="6.50932" /MaxDrop="4.759" /score="15.8109079" /energy="-12.7" /TU="U1782" /idTUdmin="U1783" /TUdmin=1100 /isTUend="FALSE" /label="downshifts" CDS complement(1908772..1908975) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390163.1" /db_xref="EnsemblGenomes-Gn:BSU22820" /db_xref="EnsemblGenomes-Tr:CAB14198" /db_xref="GOA:P50744" /db_xref="InterPro:IPR020076" /db_xref="SubtiList:BG11444" /db_xref="UniProtKB/Swiss-Prot:P50744" /translation="MNLALMKMWFALGSMGLMFLAVASIYLSRFKCQNRFLKIAISSF AYMCMLISGIIVFVVVFSGPVNE*" /label="yphE CDS" gene complement(1908772..1908975) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /label="yphE gene" promotor_-10 complement(1909011..1909030) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1909032) /Source="Nicolas_upshifts" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1909044..1909051) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1909097..1909296) /Source="Nicolas_S_feature" /locus_tag="new_2388935_2389134_c" /HighExp="S7, S8, S6, C30, BT, G135, G180, Oxctl, Cold, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, Sig-" /TUshortPSig="1, 1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S863" downshifts complement(1909140) /Source="Nicolas_upshifts" /id="D1190" /incds=0 /nref=264 /ntot=295 /MaxReadThrough="2.22999" /MaxDrop="8.05743" /score="26.216597" /energy="-14.1" /TU="NA" /idTUdmin="U1783" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1909271..1909290) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1909296) /Source="Nicolas_upshifts" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1909304..1909313) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1909313..1910350) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /EC_number="1.1.1.94" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592341, 12682299, 15557260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592341, 12682299, 15557260; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent glycerol-3-phosphate dehydrogenase" /protein_id="NP_390164.1" /db_xref="EnsemblGenomes-Gn:BSU22830" /db_xref="EnsemblGenomes-Tr:CAB14199" /db_xref="GOA:P46919" /db_xref="InterPro:IPR006109" /db_xref="InterPro:IPR006168" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR011128" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11366" /db_xref="UniProtKB/Swiss-Prot:P46919" /translation="MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELH ENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFV HVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMR AAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITR GLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEE MGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEME DLVNTFENQVK*" /label="gpsA CDS" gene complement(1909313..1910350) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /label="gpsA gene" CDS complement(1910368..1911678) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /EC_number="3.6.5.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase essential for ribosome 50S subunit assembly (maturation of the 50S subunit central protoberance)" /protein_id="NP_390165.1" /db_xref="EnsemblGenomes-Gn:BSU22840" /db_xref="EnsemblGenomes-Tr:CAB14200" /db_xref="GOA:P50743" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR016484" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031166" /db_xref="InterPro:IPR032859" /db_xref="PDB:2HJG" /db_xref="PDB:4DCS" /db_xref="PDB:4DCT" /db_xref="PDB:4DCU" /db_xref="PDB:4DCV" /db_xref="PDB:4KYU" /db_xref="PDB:5X4B" /db_xref="SubtiList:BG11443" /db_xref="UniProtKB/Swiss-Prot:P50743" /translation="MGKPVVAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYS SAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEE VAKILYRTKKPVVLAVNKLDNTEMRANIYDFYSLGFGEPYPISGTHGLGLGDLLDAVA EHFKNIPETKYNEEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDAVDTSF TYNQQEFVIVDTAGMRKKGKVYETTEKYSVLRALKAIDRSEVVAVVLDGEEGIIEQDK RIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFLDYAPILFMSALTKK RIHTLMPAIIKASENHSLRVQTNVLNDVIMDAVAMNPTPTHNGSRLKIYYATQVSVKP PSFVVFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIFARARK*" /label="der CDS" gene complement(1910368..1911678) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /label="der gene" S_feature complement(1911679..1911803) /Source="Nicolas_S_feature" /locus_tag="new_2391517_2391641_c" /HighExp="Cold, G180, G150, Oxctl, G135, C30, LBGexp, Paraq, dia0, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S864" promotor_-10 complement(1911789..1911808) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1911803) /Source="Nicolas_upshifts" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1911823..1911826) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1911832..1912026) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097755.1" /db_xref="EnsemblGenomes-Gn:BSU22849" /db_xref="EnsemblGenomes-Tr:CAX52654" /db_xref="UniProtKB/Swiss-Prot:C0H445" /translation="MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEA ILDGIAHRIGDDVYLIVKHF*" /label="ypzH CDS" gene complement(1911832..1912026) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /label="ypzH gene" CDS complement(1912023..1912916) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390166.1" /db_xref="EnsemblGenomes-Gn:BSU22850" /db_xref="EnsemblGenomes-Tr:CAB14201" /db_xref="GOA:P50742" /db_xref="InterPro:IPR025918" /db_xref="SubtiList:BG11442" /db_xref="UniProtKB/Swiss-Prot:P50742" /translation="MSDYIYPIIAGVIAGIATRLYMLKTDYRQYPTYVHGKVIHIALG LIAAGLGAIIMPALLQEEFTAITFLTLAATQFRDVRNMERNTLTQMDSYELVSRGSTY IEGIAIAFESRNYIVIFTALLTTSAYVFLSIWAAVIAAVVCFLLAMKFMSGSVLKDIV DIEYIKPRFDGPGLFVDNIYMMNIGLPEKQELILKHGMGFILTPKNFNSAATIANLGQ RQAILFDVSNVLGVYRDSGEPSLTPIAKRDLNDGRVAVFVLPQIHHPETAVQIISNVP TLENAIRMPTEFIKNQDKVIG*" /label="yphB CDS" gene complement(1912023..1912916) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /label="yphB gene" CDS complement(1912913..1913512) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390167.1" /db_xref="EnsemblGenomes-Gn:BSU22860" /db_xref="EnsemblGenomes-Tr:CAB14202" /db_xref="GOA:P50741" /db_xref="InterPro:IPR014617" /db_xref="SubtiList:BG11441" /db_xref="UniProtKB/Swiss-Prot:P50741" /translation="MEQFYYYWSMWFLWVLTTFIFEKTKRRIAVSVFILTNIILSIHD IALYFSLNAAYLMFFVCGCVYAGYLGMYRFRYIMVYLTLVAAYAFVYLFALYDPVWFI IKPEWAAVILIVLLTASVERNFEKQLVLFVLGMCQGELVYSFVIQKLAGAMAVGGFQW LNACSAGMILLFGISKYEHLASQIGQKSKRSNKGATKMS*" /label="yphA CDS" gene complement(1912913..1913512) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /label="yphA gene" promotor_-35 1913385..1913391 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1913400..1913583 /Source="Nicolas_S_feature" /locus_tag="new_2393238_2393421" /HighExp="S5, S8, S6, S7, BT, S4, ferm, nit, Pyr, G/S" /AntisenseName="yphA" /AntisenseCor="0.73324773408178501" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.6" /TUlongSig="NA" /TUlongPSig="NA" /label="S865" upshifts 1913402 /Source="Nicolas_upshifts" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1913405..1913416 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1913523..1913541) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1913542) /Source="Nicolas_upshifts" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1913557..1913562) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1913590..1913721 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="YP_003097756.2" /db_xref="EnsemblGenomes-Gn:BSU22869" /db_xref="EnsemblGenomes-Tr:CAX52655" /db_xref="InterPro:IPR025414" /db_xref="UniProtKB/Swiss-Prot:C0H446" /translation="MGKDRQEKKLKASGRVESDRDQSIHYDGATSLEQNGRFKKRKS* " /label="ypzI CDS" gene 1913590..1913721 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /label="ypzI gene" downshifts 1913709 /Source="Nicolas_upshifts" /id="D1191" /incds=0 /nref=37 /ntot=122 /MaxReadThrough="0.20384" /MaxDrop="6.94664" /score="3.33160455" /energy="-13.2" /TU="NA" /idTUdmin="U1785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1913764..1914813) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /EC_number="5.3.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12798687, 14745175, 15206931" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12798687, 14745175, 15206931; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl diphosphate isomerase (typeII)" /protein_id="NP_390168.3" /db_xref="EnsemblGenomes-Gn:BSU22870" /db_xref="EnsemblGenomes-Tr:CAB14203" /db_xref="GOA:P50740" /db_xref="InterPro:IPR000262" /db_xref="InterPro:IPR011179" /db_xref="InterPro:IPR013785" /db_xref="PDB:1P0K" /db_xref="PDB:1P0N" /db_xref="SubtiList:BG11440" /db_xref="UniProtKB/Swiss-Prot:P50740" /translation="MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVD ISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPS ERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGD RSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSK IENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASC TGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHH WLTERGVNTSSYSVR*" /label="fni CDS" gene complement(1913764..1914813) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /label="fni gene" downshifts complement(1913784) /Source="Nicolas_upshifts" /id="D1192" /incds=0 /nref=209 /ntot=250 /MaxReadThrough="1.39069" /MaxDrop="4.82362" /score="15.2467448" /energy="-13.2" /TU="NA" /idTUdmin="U1788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1914688) /Source="Nicolas_upshifts" /id="D1193" /incds=1 /nref=45 /ntot=237 /MaxReadThrough="6.15611" /MaxDrop="4.91722" /score="13.2731686" /energy="-15.7" /TU="U1788,U1789,U1790" /idTUdmin="U1788" /TUdmin="-904" /isTUend="FALSE" /label="downshifts" CDS complement(1914826..1915974) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 9862121, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA degradation presenting factor (ribosomal protein S1 homolog)" /protein_id="NP_390169.1" /db_xref="EnsemblGenomes-Gn:BSU22880" /db_xref="EnsemblGenomes-Tr:CAB14204" /db_xref="GOA:P38494" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11005" /db_xref="UniProtKB/Swiss-Prot:P38494" /translation="MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGII PISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETK EVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKN RVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQ LSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVL EGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENE ERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK*" /label="rpfA CDS" gene complement(1914826..1915974) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /label="rpfA gene" misc_feature 1915155..1915158 /Source="Nicolas_upshift_promotors" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1915182 /Source="Nicolas_upshifts" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1915248 /Source="Nicolas_upshifts" /id="D1194" /incds=1 /nref=1 /ntot=124 /MaxReadThrough="1.88188" /MaxDrop="2.8624" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1915952 /Source="Nicolas_upshifts" /id="D1195" /incds=0 /nref=3 /ntot=200 /MaxReadThrough="1.33117" /MaxDrop="3.08345" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=704 /isTUend="FALSE" /label="downshifts" S_feature complement(1915975..1916114) /Source="Nicolas_S_feature" /locus_tag="new_2395813_2395952_c" /HighExp="C90, Salt, Etha, Lbtran, HiOs, M40t90, S1, LBGtran, LoTm, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.999, 0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S866" promotor_-10 complement(1916113..1916132) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1916114) /Source="Nicolas_upshifts" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1916116..1916206) /Source="Nicolas_S_feature" /locus_tag="new_2395954_2396044_c" /HighExp="G135, G180, LBGexp, C30, Cold, Oxctl, dia0, G150, Paraq, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40511799999999998" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S867" promotor_-35 complement(1916147..1916154) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1916207..1916881) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /EC_number="2.7.4.25" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8576266, 9179491, 9862121, 11827479, 12682299, 16880539" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576266, 9179491, 9862121, 11827479, 12682299, 16880539; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidylate kinase" /protein_id="NP_390170.1" /db_xref="EnsemblGenomes-Gn:BSU22890" /db_xref="EnsemblGenomes-Tr:CAB14205" /db_xref="GOA:P38493" /db_xref="InterPro:IPR003136" /db_xref="InterPro:IPR011994" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11004" /db_xref="UniProtKB/Swiss-Prot:P38493" /translation="MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITY AALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIA AKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEE NVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEA VEQKSR*" /label="cmk CDS" gene complement(1916207..1916881) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /label="cmk gene" S_feature complement(1916882..1916959) /Source="Nicolas_S_feature" /locus_tag="new_2396720_2396797_c" /HighExp="S4, S5, S7, S8, S6, dia15, S3, Diami, dia5, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S868" CDS complement(1916960..1917136) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390171.1" /db_xref="EnsemblGenomes-Gn:BSU22900" /db_xref="EnsemblGenomes-Tr:CAB14206" /db_xref="InterPro:IPR035281" /db_xref="SubtiList:BG11003" /db_xref="UniProtKB/Swiss-Prot:P38492" /translation="MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGV DKMEENNRIETFKH*" /label="ypfB CDS" gene complement(1916960..1917136) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /label="ypfB gene" promotor_-10 complement(1917148..1917166) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1917165) /Source="Nicolas_upshifts" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1917181..1917187) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1917181..1917834) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16249258, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16249258, 23893111, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic di-GMP receptor" /protein_id="NP_390172.1" /db_xref="EnsemblGenomes-Gn:BSU22910" /db_xref="EnsemblGenomes-Tr:CAB14207" /db_xref="GOA:P38491" /db_xref="InterPro:IPR009875" /db_xref="InterPro:IPR009926" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG11002" /db_xref="UniProtKB/Swiss-Prot:P38491" /translation="MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTG RTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQY VRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEH TRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME* " /label="dgrA CDS" gene complement(1917181..1917834) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /label="dgrA gene" promotor_-10 complement(1917864..1917883) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1917877) /Source="Nicolas_upshifts" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1917899..1917903) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1917927..1919279) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination membrane component" /protein_id="NP_390173.1" /db_xref="EnsemblGenomes-Gn:BSU22920" /db_xref="EnsemblGenomes-Tr:CAB14208" /db_xref="GOA:P38490" /db_xref="InterPro:IPR014239" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG11001" /db_xref="UniProtKB/Swiss-Prot:P38490" /translation="MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFH ELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEE LLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRW MDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGK QISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGG HPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPV ENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQ VRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL *" /label="sleC CDS" gene complement(1917927..1919279) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /label="sleC gene" downshifts complement(1917942) /Source="Nicolas_upshifts" /id="D1196" /incds=0 /nref=21 /ntot=44 /MaxReadThrough="0.647060000000002" /MaxDrop="5.74199" /score="16.6521528" /energy="-10.1" /TU="NA" /idTUdmin="U1791" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1919314..1920231) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination cortex-lytic enzyme" /protein_id="NP_390174.1" /db_xref="EnsemblGenomes-Gn:BSU22930" /db_xref="EnsemblGenomes-Tr:CAB14209" /db_xref="GOA:P50739" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR011105" /db_xref="InterPro:IPR014224" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11439" /db_xref="UniProtKB/Swiss-Prot:P50739" /translation="MKSKGSIMACLILFSFTITTFINTETISAFSNQVIQRGATGDDV VELQARLQYNGYYNGKIDGVYGWGTYWAVRNFQDQFGLKEVDGLVGAKTKQTLICKSK YYREYVMEQLNKGNTFTHYGKIPLKYQTKPSKAATQKARQQAEARQKQPAEKTTQKPK ANANKQQNNTPAKARKQDAVAANMPGGFSNNDIRLLAQAVYGEARGEPYEGQVAIAAV ILNRLNSPLFPNSVAGVIFEPLAFTAVADGQIYMQPNETAREAVLDAINGWDPSEEAL YYFNPDTATSPWIWGRPQIKRIGKHIFCE*" /label="sleB CDS" gene complement(1919314..1920231) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /label="sleB gene" downshifts complement(1919702) /Source="Nicolas_upshifts" /id="D1197" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.35344" /MaxDrop="4.29326" /score="-3.16364421" /energy="-21.7" /TU="U1791,U1792" /idTUdmin="U1793" /TUdmin=682 /isTUend="FALSE" /label="downshifts" misc_feature complement(1919853..1919860) /Source="Nicolas_upshift_promotors" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1919856) /Source="Nicolas_upshifts" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1920269..1920280) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1920278) /Source="Nicolas_upshifts" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1920294..1920300) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1920370..1921026) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease required for RsiW anti-sigma(W) degradation" /protein_id="NP_390175.1" /db_xref="EnsemblGenomes-Gn:BSU22940" /db_xref="EnsemblGenomes-Tr:CAB14210" /db_xref="GOA:P50738" /db_xref="InterPro:IPR023596" /db_xref="InterPro:IPR026898" /db_xref="SubtiList:BG11438" /db_xref="UniProtKB/Swiss-Prot:P50738" /translation="MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLV FPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVY GASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKAR VKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV *" /label="prsW CDS" gene complement(1920370..1921026) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /label="prsW gene" downshifts complement(1920384) /Source="Nicolas_upshifts" /id="D1198" /incds=0 /nref=239 /ntot=262 /MaxReadThrough="0.9181" /MaxDrop="6.61797" /score="-3.16364421" /energy="-21.7" /TU="NA" /idTUdmin="U1793" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1921051..1921070) /Source="Nicolas_upshift_promotors" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1921066) /Source="Nicolas_upshifts" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1921146..1922120) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /EC_number="1.8.-.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacillithiol biosynthesis thiol disulfide oxidoreductase" /protein_id="NP_390176.2" /db_xref="EnsemblGenomes-Gn:BSU22950" /db_xref="EnsemblGenomes-Tr:CAB14211" /db_xref="GOA:P50736" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR023856" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11436" /db_xref="UniProtKB/Swiss-Prot:P50736" /translation="MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNY PTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTK TQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDV VVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFG ACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFN EETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH*" /label="ypdA CDS" gene complement(1921146..1922120) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /label="ypdA gene" downshifts complement(1921154) /Source="Nicolas_upshifts" /id="D1199" /incds=0 /nref=239 /ntot=263 /MaxReadThrough="3.524" /MaxDrop="6.45954" /score="27.4058676" /energy="-12.2" /TU="U1796" /idTUdmin="U1796" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-35 1921974..1921979 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1921995..1922013 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1922005..1922198 /Source="Nicolas_S_feature" /locus_tag="new_2401843_2402036" /HighExp="S8, S6, S7, S4, S5, C30, S3, BT, B36, C90" /AntisenseName="ypdA" /AntisenseCor="-0.487730736536516" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S869" upshifts 1922005 /Source="Nicolas_upshifts" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="upshifts" downshifts 1922156 /Source="Nicolas_upshifts" /id="D1200" /incds=0 /nref=13 /ntot=27 /MaxReadThrough="1.93985" /MaxDrop="5.69954" /score="23.7306175" /energy="-9.3" /TU="NA" /idTUdmin="U1794" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1922229..1923512) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 18326565, 22178969, 22720735, 25610436" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 18326565, 22178969, 22720735, 25610436; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cryptic glutamate dehydrogenase (active after removal of a 9 bp insert)" /protein_id="NP_390177.2" /db_xref="EnsemblGenomes-Gn:BSU22960" /db_xref="EnsemblGenomes-Tr:CAB14212" /db_xref="GOA:P50735" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K8Z" /db_xref="SubtiList:BG11435" /db_xref="UniProtKB/Swiss-Prot:P50735" /translation="MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKE PMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSI WMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDV FTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKR GIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRD SFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTL EGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFN NIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI*" /label="gudB CDS" gene complement(1922229..1923512) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /label="gudB gene" downshifts complement(1922232) /Source="Nicolas_upshifts" /id="D1201" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="7.92262" /MaxDrop="4.04542" /score="18.1400723" /energy="-9.3" /TU="U1796" /idTUdmin="U1797" /TUdmin=1345 /isTUend="FALSE" /label="downshifts" promotor_-35 1922270..1922276 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1922288..1922292 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1922288 /Source="Nicolas_upshifts" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1923555..1923574) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1923576) /Source="Nicolas_upshifts" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1923589..1923596) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1923668..1924252) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914365, 19801546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914365, 19801546; Product type f: factor" /codon_start=1 /transl_table=11 /product="adaptor to ClpC; regulator of competence and sporulation" /protein_id="NP_390178.1" /db_xref="EnsemblGenomes-Gn:BSU22970" /db_xref="EnsemblGenomes-Tr:CAB14213" /db_xref="GOA:P50734" /db_xref="InterPro:IPR008681" /db_xref="PDB:3JTN" /db_xref="PDB:3JTO" /db_xref="SubtiList:BG11434" /db_xref="UniProtKB/Swiss-Prot:P50734" /translation="MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDM MNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDE SADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLA EYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS*" /label="mecB CDS" gene complement(1923668..1924252) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /label="mecB gene" downshifts complement(1923670) /Source="Nicolas_upshifts" /id="D1202" /incds=0 /nref=258 /ntot=274 /MaxReadThrough="3.02006" /MaxDrop="7.92719" /score="23.8885529" /energy="-7.1" /TU="U1797" /idTUdmin="U1797" /TUdmin="-93" /isTUend="FALSE" /label="downshifts" S_feature complement(1924253..1924334) /Source="Nicolas_S_feature" /locus_tag="new_2404091_2404172_c" /HighExp="dia5, Diami, Etha, dia15, C90, Salt, LPhT, Heat, MG-0.2, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S870" promotor_-10 complement(1924327..1924346) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-10" upshifts complement(1924334) /Source="Nicolas_upshifts" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="upshifts" promotor_-35 complement(1924360..1924367) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-35" CDS complement(1924411..1925190) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 17434969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390179.1" /db_xref="EnsemblGenomes-Gn:BSU22980" /db_xref="EnsemblGenomes-Tr:CAB14214" /db_xref="GOA:P50733" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11433" /db_xref="UniProtKB/Swiss-Prot:P50733" /translation="MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGK PPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHF GVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEM DHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYEL GKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE*" /label="ypbG CDS" gene complement(1924411..1925190) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /label="ypbG gene" promotor_-10 complement(1925216..1925231) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-10" upshifts complement(1925227) /Source="Nicolas_upshifts" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="upshifts" promotor_-35 complement(1925243..1925252) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-35" CDS complement(1925276..1925719) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390180.1" /db_xref="EnsemblGenomes-Gn:BSU22990" /db_xref="EnsemblGenomes-Tr:CAB14215" /db_xref="GOA:P50732" /db_xref="InterPro:IPR020210" /db_xref="SubtiList:BG11432" /db_xref="UniProtKB/Swiss-Prot:P50732" /translation="MESLWNQLDQFTDAPTKQMLQALVKRKQKFENYAAQCRRWRWAS LICLGLLCVMIMIKSPEPQLILQEILSHTFYLFWMLATAFAYCTSYYFKKKEEKSETD FHKLRCEIIQKSTDLWPQPDKWKARESVFHMMKHKYDINLYFESK*" /label="ypbF CDS" gene complement(1925276..1925719) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /label="ypbF gene" downshifts complement(1925293) /Source="Nicolas_upshifts" /id="D1203" /incds=0 /nref=4 /ntot=112 /MaxReadThrough="4.67294" /MaxDrop="3.33254" /score="6.86206051" /energy="-7.5" /TU="U1801" /idTUdmin="U1799" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1925782..1926504) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855244, 22950025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme possibly involved in cell wall turnover" /protein_id="NP_390181.1" /db_xref="EnsemblGenomes-Gn:BSU23000" /db_xref="EnsemblGenomes-Tr:CAB14216" /db_xref="GOA:P50731" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11431" /db_xref="UniProtKB/Swiss-Prot:P50731" /translation="MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQR EQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYE VVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEAT AAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRA YNHLNGNDVYTGQVLDIPLMDE*" /label="ypbE CDS" gene complement(1925782..1926504) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /label="ypbE gene" downshifts complement(1926063) /Source="Nicolas_upshifts" /id="D1204" /incds=1 /nref=4 /ntot=93 /MaxReadThrough="4.30678" /MaxDrop="3.33147" /score="6.86206051" /energy="-7.5" /TU="U1799,U1801" /idTUdmin="U1799" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" CDS complement(1926455..1927024) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390182.1" /db_xref="EnsemblGenomes-Gn:BSU23010" /db_xref="EnsemblGenomes-Tr:CAB14217" /db_xref="GOA:P50730" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG11430" /db_xref="UniProtKB/Swiss-Prot:P50730" /translation="MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAV IVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTH IGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVF ACQIRFEHVRRDKHDEHVESREKKSPESL*" /label="ypbD CDS" gene complement(1926455..1927024) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /label="ypbD gene" promotor_-10 complement(1926773..1926791) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1926789) /Source="Nicolas_upshifts" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1926806..1926812) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1927043..1927789 /Source="Nicolas_S_feature" /locus_tag="new_2406881_2407627" /HighExp="S6, S8, S7, C30, BT, S5, C90, Pyr, BC, Sw" /AntisenseName="recQ" /AntisenseCor="-0.47918253719211501" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S871" CDS complement(1927084..1928574) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16385024, 25246477, 26001966, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385024, 25246477, 26001966, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_390183.1" /db_xref="EnsemblGenomes-Gn:BSU23020" /db_xref="EnsemblGenomes-Tr:CAB14218" /db_xref="GOA:P50729" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002464" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11407" /db_xref="UniProtKB/Swiss-Prot:P50729" /translation="MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGK SLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEH IHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRK KLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKID RVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFI HNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRA PGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIH LFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGN LPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN*" /label="recS CDS" gene complement(1927084..1928574) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /label="recS gene" CDS complement(1928567..1929625) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /experiment="publication(s) with functional evidences, PMID:21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21170359; Product type f: factor" /codon_start=1 /transl_table=11 /product="subunit of the platform for genome maintenance machinery" /protein_id="NP_390184.1" /db_xref="EnsemblGenomes-Gn:BSU23030" /db_xref="EnsemblGenomes-Tr:CAB14219" /db_xref="InterPro:IPR008308" /db_xref="InterPro:IPR029491" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11429" /db_xref="UniProtKB/Swiss-Prot:P50728" /translation="MSLNYFDIMVLDCLCKINGERSGSAVFHLFKGKRSSQTIQDAGL FQTAKYFGMAAKCSRSDISASLDKLEKHSYLAPMSESDTYKVTASGAAVLRHALSERP WPVHCHGAHYQQAAGVLWKRLSLLVQVLSHKQQGSRQYIPVTKDHKTLHWVKKYLSRH TDHIEMAKSLFAMLEAHLKKIENKAAQIFVYSLTSHHRIGYTSRQLADTLKEDEWYVY IMFWASVHYFIHSLPECEDALLKDLLSDVHLDNALTESTRKTWQMVKQGFPIQRIAEI RKLKTATIEDHIVEISLHEPAFMINDYVSAEDQLQIAEFAKRMRTNKIKQIRDGLEQR FSYFQIRLALTKQVQQYD*" /label="gmmB CDS" gene complement(1928567..1929625) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /label="gmmB gene" promotor_-35 1928915..1928924 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1928935..1929725 /Source="Nicolas_S_feature" /locus_tag="new_2408773_2409563" /HighExp="S8, S6, S7, S5, BT, B36, Pyr, G/S, B60, nit" /AntisenseName="ypbB" /AntisenseCor="-0.76734368116597995" /AntisenseRegPval="-52.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S872" upshifts 1928935 /Source="Nicolas_upshifts" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1928937..1928956 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1929666..1929685) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1929689) /Source="Nicolas_upshifts" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1929697..1929704) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1929703..1929709 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-35" promotor_-10 1929723..1929742 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-10" S_feature 1929727..1929796 /Source="Nicolas_S_feature" /locus_tag="new_2409565_2409634" /HighExp="S6, S8, S7, S5, BT, B36, C30, Pyr, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="0.991, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S873" upshifts 1929727 /Source="Nicolas_upshifts" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="upshifts" promotor_-35 1929776..1929783 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1929798..1929890 /Source="Nicolas_S_feature" /locus_tag="new_2409636_2409728" /HighExp="LPhT, LBGstat, HPh, C90, LBGtran, C30, Lbtran, Cold, LPh, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.996" /TUlongSig="SigB" /TUlongPSig="0.991" /label="S874" promotor_-10 1929798..1929817 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1929798 /Source="Nicolas_upshifts" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="upshifts" CDS 1929891..1930139 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12538057, 21665975" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12538057, 21665975; Product type c: carrier" /codon_start=1 /transl_table=11 /product="ferredoxin" /protein_id="NP_390185.1" /db_xref="EnsemblGenomes-Gn:BSU23040" /db_xref="EnsemblGenomes-Tr:CAB14220" /db_xref="GOA:P50727" /db_xref="InterPro:IPR001080" /db_xref="InterPro:IPR017896" /db_xref="SubtiList:BG11388" /db_xref="UniProtKB/Swiss-Prot:P50727" /translation="MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDENKGV VEVPEVLEEDMIDAFEGCPTDSIKVADEPFEGDPLKFE*" /label="fer CDS" gene 1929891..1930139 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /label="fer gene" downshifts 1930123 /Source="Nicolas_upshifts" /id="D1205" /incds=0 /nref=221 /ntot=291 /MaxReadThrough="3.16016" /MaxDrop="8.38074" /score="34.9672707" /energy="-9.9" /TU="U1803" /idTUdmin="U1800" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1930179..1930751) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12456892, 15849754, 16850406, 17693491, 25438558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15849754, 16850406, 17693491, 25438558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="FMN permease" /protein_id="NP_390186.1" /db_xref="EnsemblGenomes-Gn:BSU23050" /db_xref="EnsemblGenomes-Tr:CAB14237" /db_xref="GOA:P50726" /db_xref="InterPro:IPR024529" /db_xref="InterPro:IPR025720" /db_xref="SubtiList:BG11428" /db_xref="UniProtKB/Swiss-Prot:P50726" /translation="MKVKKLVVVSMLSSIAFVLMLLNFPFPGLPDYLKIDFSDVPAII AILIYGPLAGIAVEAIKNVLQYIIQGSMAGVPVGQVANFIAGTLFILPTAFLFKKLNS AKGLAVSLLLGTAAMTILMSILNYVLILPAYTWFLHSPALSDSALKTAVVAGILPFNM IKGIVITVVFSLIFIKLKPWIEQQRSAHIH*" /label="fmnP CDS" gene complement(1930179..1930751) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /label="fmnP gene" downshifts complement(1930199) /Source="Nicolas_upshifts" /id="D1206" /incds=0 /nref=103 /ntot=231 /MaxReadThrough="2.60651" /MaxDrop="4.95518" /score="35.0684207" /energy="-9.9" /TU="NA" /idTUdmin="U1804" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1930743..1931050) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /product="flavin mononucleotide riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508; Product type n: RNA" /label="fswB RNA" gene complement(1930743..1931050) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /label="fswB gene" S_feature complement(1930752..1930856) /Source="Nicolas_S_feature" /locus_tag="new_2410590_2410694_c" /HighExp="S1, LPhT, M9-stat, B60, Heat, T0.30H, Gly, S5, BC, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S875" promotor_-10 complement(1931049..1931068) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1931065) /Source="Nicolas_upshifts" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1931082..1931088) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1931177..1931184 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1931195 /Source="Nicolas_upshifts" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1931199..1931218 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1931248..1932825 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /EC_number="1.1.1.95" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoglycerate dehydrogenase" /protein_id="NP_390188.2" /db_xref="EnsemblGenomes-Gn:BSU23070" /db_xref="EnsemblGenomes-Tr:CAB14239" /db_xref="GOA:P35136" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR006236" /db_xref="InterPro:IPR029009" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10509" /db_xref="UniProtKB/Swiss-Prot:P35136" /translation="MFRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHTFDAL LVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH TFAMISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAF GMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKT KKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPLVIATPH LGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGS LVSQCMKEPVQDVAIQYEGTIAKLETSFITKALLSGFLKPRVDSTVNEVNAGGVAKER GISFSEKISSSESGYDNCISVKVTGDRSTFTVTATYIPHFGERIVEINGFNIDFYPTG HLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKIVK ELTNVPDIVSVKLIDLP*" /label="serA CDS" gene 1931248..1932825 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /label="serA gene" downshifts 1932807 /Source="Nicolas_upshifts" /id="D1207" /incds=0 /nref=246 /ntot=311 /MaxReadThrough="3.23011" /MaxDrop="8.29454" /score="32.0086708" /energy="-10.2" /TU="U1805" /idTUdmin="U1805" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(1932868..1933635) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6442253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6442253; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase" /protein_id="NP_390189.1" /db_xref="EnsemblGenomes-Gn:BSU23080" /db_xref="EnsemblGenomes-Tr:CAB14240" /db_xref="GOA:P35146" /db_xref="InterPro:IPR001381" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018508" /db_xref="SubtiList:BG10538" /db_xref="UniProtKB/Swiss-Prot:P35146" /translation="MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDI VEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLE SAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRK MQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEV FGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG*" /label="aroC CDS" gene complement(1932868..1933635) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /label="aroC gene" downshifts complement(1932883) /Source="Nicolas_upshifts" /id="D1208" /incds=0 /nref=152 /ntot=231 /MaxReadThrough="2.53428" /MaxDrop="5.12103" /score="24.3727755" /energy="-10.2" /TU="NA" /idTUdmin="U1806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1933137..1933749 /Source="Nicolas_S_feature" /locus_tag="new_2412975_2413587" /HighExp="B36, C30, LoTm, B60, C90, HiOs, BI, Sw, T1.0H, BT" /AntisenseName="aroC" /AntisenseCor="4.7354591214804703E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S876" promotor_-10 complement(1933662..1933681) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1933675) /Source="Nicolas_upshifts" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1933696..1933699) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1933709 /Source="Nicolas_upshifts" /id="D1209" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="2.02363" /MaxDrop="5.64228" /score="10.7892325" /energy="-8.5" /TU="NA" /idTUdmin="U1805" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS complement(1933747..1934853) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9139908, 9393439, 10712692, 14762009, 16306698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139908, 9393439, 10712692, 14762009, 16306698; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma(X) activity" /protein_id="NP_390190.2" /db_xref="EnsemblGenomes-Gn:BSU23090" /db_xref="EnsemblGenomes-Tr:CAB14241" /db_xref="GOA:P35166" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10537" /db_xref="UniProtKB/Swiss-Prot:P35166" /translation="MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPA VRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQ TSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAIT IPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLS DQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEME SSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGF TEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN*" /label="rsiX CDS" gene complement(1933747..1934853) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /label="rsiX gene" downshifts complement(1933764) /Source="Nicolas_upshifts" /id="D1210" /incds=0 /nref=155 /ntot=242 /MaxReadThrough="3.84557" /MaxDrop="5.30684" /score="7.9467954" /energy="-6.7" /TU="U1809" /idTUdmin="U1806" /TUdmin="-881" /isTUend="FALSE" /label="downshifts" CDS complement(1934789..1935373) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9636707, 11222589, 12399481, 14762009, 19767430, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9636707, 11222589, 12399481, 14762009, 19767430, 27965645; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X)" /protein_id="NP_390191.2" /db_xref="EnsemblGenomes-Gn:BSU23100" /db_xref="EnsemblGenomes-Tr:CAB14242" /db_xref="GOA:P35165" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10536" /db_xref="UniProtKB/Swiss-Prot:P35165" /translation="MEETFQLLYDTYHQDLYQFLFYMVKDKNQTEDLLQEVYIRVLNS YHTFEGRSSEKTWLLSIARHVAIDWFRKQQTIRQRILGTFDWDTQDVRDQQLLPDELA VQHENVREIYAALDQCTIDQRAVIILRFIQGYSIQETAKALRFSESKVKTTQHRGLKV LRKHMELLREELMDDEVRMERRTDKGVVKSTSGS*" /label="sigX CDS" gene complement(1934789..1935373) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /label="sigX gene" promotor_-35 1935167..1935172 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1935183 /Source="Nicolas_upshifts" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1935187..1935191 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1935324..1935329 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1935341 /Source="Nicolas_upshifts" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1935345..1935363 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1935381 /Source="Nicolas_upshifts" /id="D1211" /incds=0 /nref=8 /ntot=81 /MaxReadThrough="5.89234" /MaxDrop="4.38483" /score="6.57298987" /energy="-13.5" /TU="U1808" /idTUdmin="U1807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1935422..1935441) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1935426..1935533 /Source="Nicolas_S_feature" /locus_tag="new_2415264_2415371" /HighExp="S4, S8, S6, S7, C30, S3, LoTm, B60, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S877" upshifts complement(1935430) /Source="Nicolas_upshifts" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1935454..1935461) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1935489 /Source="Nicolas_upshifts" /id="D1212" /incds=0 /nref=12 /ntot=64 /MaxReadThrough="2.08559" /MaxDrop="4.36303" /score="6.57298987" /energy="-13.5" /TU="NA" /idTUdmin="U1808" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(1935518..1935576) /Source="Nicolas_S_feature" /locus_tag="new_2415356_2415414_c" /HighExp="Lbstat, BI, nit, S0, M40t90, Lbtran, M0t90, G135, Sw, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S878" downshifts complement(1935549) /Source="Nicolas_upshifts" /id="D1213" /incds=0 /nref=156 /ntot=252 /MaxReadThrough="2.62215" /MaxDrop="6.99198" /score="33.3049318" /energy="-13.5" /TU="NA" /idTUdmin="U1810" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1935577..1937346) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase (ResD / ResE)" /protein_id="NP_390192.1" /db_xref="EnsemblGenomes-Gn:BSU23110" /db_xref="EnsemblGenomes-Tr:CAB14243" /db_xref="GOA:P35164" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4ZR7" /db_xref="SubtiList:BG10535" /db_xref="UniProtKB/Swiss-Prot:P35164" /translation="MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAEN DLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSI TVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSL LAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTK IPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTIL VTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVL LMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVD DIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKII RKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVH SVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHN GSITVHSRIDKGTTFSFYIPTKR*" /label="resE CDS" gene complement(1935577..1937346) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /label="resE gene" downshifts complement(1935633) /Source="Nicolas_upshifts" /id="D1214" /incds=0 /nref=5 /ntot=13 /MaxReadThrough="7.56028" /MaxDrop="3.58685" /score="33.3049318" /energy="-13.5" /TU="U1810,U1811,U1812" /idTUdmin="U1810" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(1937343..1938065) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator (ResD / ResE)" /protein_id="NP_390193.2" /db_xref="EnsemblGenomes-Gn:BSU23120" /db_xref="EnsemblGenomes-Tr:CAB14244" /db_xref="GOA:P35163" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10534" /db_xref="UniProtKB/Swiss-Prot:P35163" /translation="MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIA KGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDD YIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTE VSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVS PEAAKKIVTVWGVGYKFEVGAE*" /label="resD CDS" gene complement(1937343..1938065) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /label="resD gene" S_feature complement(1938066..1938145) /Source="Nicolas_S_feature" /locus_tag="new_2417904_2417983_c" /HighExp="Lbstat, M0t90, ferm, M40t90, S2, S0, nit, M40t45, BI, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S879" CDS complement(1938146..1939321) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10844653, 12682299, 15849754, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844653, 12682299, 15849754, 16850406, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390194.2" /db_xref="EnsemblGenomes-Gn:BSU23130" /db_xref="EnsemblGenomes-Tr:CAB14245" /db_xref="GOA:P35162" /db_xref="InterPro:IPR002541" /db_xref="InterPro:IPR017562" /db_xref="SubtiList:BG10533" /db_xref="UniProtKB/Swiss-Prot:P35162" /translation="MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIG ITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLG LFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFL LKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMV YEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRK RISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPK EVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA* " /label="resC CDS" gene complement(1938146..1939321) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /label="resC gene" CDS complement(1939341..1940969) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9395519, 10844653, 12682299, 16825793, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9395519, 10844653, 12682299, 16825793, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390195.1" /db_xref="EnsemblGenomes-Gn:BSU23140" /db_xref="EnsemblGenomes-Tr:CAB14246" /db_xref="GOA:P35161" /db_xref="InterPro:IPR007816" /db_xref="SubtiList:BG10532" /db_xref="UniProtKB/Swiss-Prot:P35161" /translation="MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARR SQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQ YGTFGQLYYLLGFHHLYGSWWYLLLIASIGISLVICSLDRVIPLYRALKNQGVRRSPA FLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHI GLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEK KVFADAIDRVGDGRVAKNFQTDAVLYKREGKIVYGEKPKLEKVTEEDIRVNQPLRFDS FSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLP DFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNKYKLKFD HVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQGMYWQHRRIWLHSQDGAVMVAGHT NKNWFGLKKDLAFILADSGLTEPVDQKELIKTQK*" /label="resB CDS" gene complement(1939341..1940969) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /label="resB gene" CDS complement(1940966..1941505) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein)" /protein_id="NP_390196.2" /db_xref="EnsemblGenomes-Gn:BSU23150" /db_xref="EnsemblGenomes-Tr:CAB14247" /db_xref="GOA:P35160" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR023555" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ST9" /db_xref="PDB:1SU9" /db_xref="PDB:2F9S" /db_xref="PDB:2H19" /db_xref="PDB:2H1A" /db_xref="PDB:2H1B" /db_xref="PDB:2H1D" /db_xref="PDB:2H1G" /db_xref="PDB:3C71" /db_xref="PDB:3C73" /db_xref="SubtiList:BG10531" /db_xref="UniProtKB/Swiss-Prot:P35160" /translation="MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPN FVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVN VGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM TESMIHDYMNLIKPGETSG*" /label="resA CDS" gene complement(1940966..1941505) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /label="resA gene" S_feature complement(1941506..1941599) /Source="Nicolas_S_feature" /locus_tag="new_2421344_2421437_c" /HighExp="LBGtran, LBGstat, G180, Oxctl, H2O2, G150, M0t90, G135, Paraq, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S880" CDS complement(1941600..1942334) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /EC_number="4.2.1.70" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9888802, 24214967" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888802, 24214967; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA pseudouridine 2633 (=2605 standard) pseudouridine synthase" /protein_id="NP_390197.2" /db_xref="EnsemblGenomes-Gn:BSU23160" /db_xref="EnsemblGenomes-Tr:CAB14248" /db_xref="GOA:P35159" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10530" /db_xref="UniProtKB/Swiss-Prot:P35159" /translation="MERLQKVIAHAGVASRRKAEELIKEGKVKVNGKVVTELGVKVTG SDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGRLD YDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA PAKAKLLSLDKKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLH TGDARELTPHEVKRLRALADHGKNAF*" /label="rluB CDS" gene complement(1941600..1942334) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /label="rluB gene" promotor_-10 complement(1942343..1942362) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1942366) /Source="Nicolas_upshifts" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1942377..1942381) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1942426..1942962) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390198.2" /db_xref="EnsemblGenomes-Gn:BSU23170" /db_xref="EnsemblGenomes-Tr:CAB14249" /db_xref="GOA:P35158" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10529" /db_xref="UniProtKB/Swiss-Prot:P35158" /translation="MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEI AFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAA LGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLAD LIGVVASIIIVTLLFGSA*" /label="spmB CDS" gene complement(1942426..1942962) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /label="spmB gene" promotor_-10 complement(1942431..1942450) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1942435) /Source="Nicolas_upshifts" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1942465..1942472) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1942967..1943557) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390199.1" /db_xref="EnsemblGenomes-Gn:BSU23180" /db_xref="EnsemblGenomes-Tr:CAB14250" /db_xref="GOA:P35157" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10528" /db_xref="UniProtKB/Swiss-Prot:P35157" /translation="MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGL MSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFG LGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSK TPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR*" /label="spmA CDS" gene complement(1942967..1943557) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /label="spmA gene" CDS complement(1943545..1944693) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /EC_number="3.4.16.4" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 8892816, 9864321, 10498740, 18266856, 19542328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 8892816, 9864321, 10498740, 18266856, 19542328; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5*) (required for spore cortex)" /protein_id="NP_390200.1" /db_xref="EnsemblGenomes-Gn:BSU23190" /db_xref="EnsemblGenomes-Tr:CAB14251" /db_xref="GOA:P35150" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR018044" /db_xref="PDB:3MFD" /db_xref="SubtiList:BG10527" /db_xref="UniProtKB/Swiss-Prot:P35150" /translation="MRIFKKAVFVIMISFLIATVNVNTAHAAIDVSAKSAIIIDGASG RVLYAKDEHQKRRIASITKIMTAVLAIESGKMDQTVTVSANAVRTEGSAIYLTEGQKV KLKDLVYGLMLRSGNDAAVAIAEHVGGSLDGFVYMMNQKAEQLGMKNTRFQNPHGLDD HENHYSTAYDMAILTKYAMKLKDYQKISGTKIYKAETMESVWKNKNKLLTMLYPYSTG GKTGYTKLAKRTLVSTASKDGIDLIAVTINDPNDWDDHMKMFNYVFEHYQTYLIAKKG DIPKLKGTFYESKAFIKRDITYLLTEEEKENVKINTTLLKPKKAWEKDASKIPDIVGH MEIMFNDATIAKVPIYYENERHQKPKKQFFETFKSIFLNAAGGAKWSI*" /label="dacB CDS" gene complement(1943545..1944693) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /label="dacB gene" promotor_-10 complement(1944715..1944733) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1944722) /Source="Nicolas_upshifts" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1944748..1944753) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1944816..1945355) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12065423" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390201.1" /db_xref="EnsemblGenomes-Gn:BSU23200" /db_xref="EnsemblGenomes-Tr:CAB14252" /db_xref="InterPro:IPR025013" /db_xref="SubtiList:BG10526" /db_xref="UniProtKB/Swiss-Prot:P35156" /translation="MKEAKCERQIHEGKIPNEMGHSIVRAQTQKTGEFLSMVVNTVND YLNQTTLESLQAELPIEKGYCCDVLSTLRRMAVFCEGGAEACRRLLMQEPFQEARAEK TLYNVYHQCIEEFFMPKKDTWCENSRASYTGVSAIEFYHAVPASLEQLLLPLSAAFLK MREELAHYEASGSSMAPIR*" /label="ypuI CDS" gene complement(1944816..1945355) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /label="ypuI gene" downshifts complement(1944829) /Source="Nicolas_upshifts" /id="D1215" /incds=0 /nref=219 /ntot=260 /MaxReadThrough="1.63638" /MaxDrop="8.00748" /score="36.7302977" /energy="-12.2" /TU="NA" /idTUdmin="U1813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1945364..1945381) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1945379) /Source="Nicolas_upshifts" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1945396..1945401) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1945410..1946003) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation factor" /protein_id="NP_390202.1" /db_xref="EnsemblGenomes-Gn:BSU23210" /db_xref="EnsemblGenomes-Tr:CAB14253" /db_xref="GOA:P35155" /db_xref="InterPro:IPR005234" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10525" /db_xref="UniProtKB/Swiss-Prot:P35155" /translation="MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIM ADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVS YKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGL KTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK*" /label="spcB CDS" gene complement(1945410..1946003) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /label="spcB gene" CDS complement(1945993..1946748) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and partitioning factor" /protein_id="NP_390203.1" /db_xref="EnsemblGenomes-Gn:BSU23220" /db_xref="EnsemblGenomes-Tr:CAB14254" /db_xref="GOA:P35154" /db_xref="InterPro:IPR003768" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG10524" /db_xref="UniProtKB/Swiss-Prot:P35154" /translation="MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLY VHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLI EYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKV LKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFL AVLELMKNQLVLIEQEHNFSDIYITGSESIHGA*" /label="scpA CDS" gene complement(1945993..1946748) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /label="scpA gene" promotor_-35 1946592..1946601 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1946614..1946633 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1946623 /Source="Nicolas_upshifts" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1946794..1946813) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1946809) /Source="Nicolas_upshifts" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1946827..1946834) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1946974..1946981 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1946992..1947011 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1946997 /Source="Nicolas_upshifts" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="upshifts" CDS 1947029..1947553 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390204.1" /db_xref="EnsemblGenomes-Gn:BSU23230" /db_xref="EnsemblGenomes-Tr:CAB14255" /db_xref="InterPro:IPR005500" /db_xref="InterPro:IPR023203" /db_xref="SubtiList:BG10523" /db_xref="UniProtKB/Swiss-Prot:P17617" /translation="MYPKAYIDYLVEFHATRDYFECHEILEEYWKEDPPKKRKRYWVG FIQLAVALYHHRRQNTAGAKRLMANSIRILQAEHRAVEDLGLDHGRLLELMQSVYEQI ETVSAYKSIILPIKDEKLEEACRIECRKKKYTWGQPSALSNIFLIDKHRLRDRTDVIR EREKEIERRKKSRD*" /label="ypuF CDS" gene 1947029..1947553 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /label="ypuF gene" CDS complement(1947567..1947941) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15466513, 25349719; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative riboflavin synthesis-related N-acetyltransferase" /protein_id="NP_390205.1" /db_xref="EnsemblGenomes-Gn:BSU23240" /db_xref="EnsemblGenomes-Tr:CAB14256" /db_xref="GOA:P17622" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10522" /db_xref="UniProtKB/Swiss-Prot:P17622" /translation="MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQL FLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPN ELTQSFFERCQGQQDQDISYNN*" /label="ypzK CDS" gene complement(1947567..1947941) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /label="ypzK gene" downshifts complement(1947583) /Source="Nicolas_upshifts" /id="D1216" /incds=0 /nref=264 /ntot=275 /MaxReadThrough="1.34496" /MaxDrop="8.09525" /score="39.5464967" /energy="-14.3" /TU="NA" /idTUdmin="U1817" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1948003..1948022) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1948015) /Source="Nicolas_upshifts" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1948034..1948041) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1948054..1948518) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /EC_number="2.5.1.78" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3100522, 7473709, 10881048, 12456892, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3100522, 7473709, 10881048, 12456892, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase, beta subunit" /protein_id="NP_390206.1" /db_xref="EnsemblGenomes-Gn:BSU23250" /db_xref="EnsemblGenomes-Tr:CAB14257" /db_xref="GOA:P11998" /db_xref="InterPro:IPR002180" /db_xref="InterPro:IPR034964" /db_xref="InterPro:IPR036467" /db_xref="PDB:1RVV" /db_xref="PDB:1ZIS" /db_xref="SubtiList:BG10521" /db_xref="UniProtKB/Swiss-Prot:P11998" /translation="MNIIQGNLVGTGLKIGIVVGRFNDFITSKLLSGAEDALLRHGVD TNDIDVAWVPGAFEIPFAAKKMAETKKYDAIITLGTVIRGATTHYDYVCNEAAKGIAQ AANTTGVPVIFGIVTTENIEQAIERAGTKAGNKGVDCAVSAIEMANLNRSFE*" /label="ribH CDS" gene complement(1948054..1948518) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /label="ribH gene" promotor_-35 1948389..1948393 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1948407..1948411 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1948410 /Source="Nicolas_upshifts" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1948551..1949747) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /EC_number="3.5.4.25" /EC_number="4.1.99.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9297088, 9515916, 12456892, 19583770, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9297088, 9515916, 12456892, 19583770, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II" /protein_id="NP_390207.1" /db_xref="EnsemblGenomes-Gn:BSU23260" /db_xref="EnsemblGenomes-Tr:CAB14258" /db_xref="GOA:P17620" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /db_xref="InterPro:IPR016299" /db_xref="InterPro:IPR017945" /db_xref="InterPro:IPR032677" /db_xref="InterPro:IPR036144" /db_xref="SubtiList:BG10520" /db_xref="UniProtKB/Swiss-Prot:P17620" /translation="MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVI NFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQER SFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGT FKVYGYTNEVDGKEHVAFVMGDVPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAA LNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEANEALGFLPDLRNYGI GAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKL GHLLHF*" /label="ribBA CDS" gene complement(1948551..1949747) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /label="ribBA gene" CDS complement(1949762..1950409) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /EC_number="2.5.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2106516, 12456892" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2106516, 12456892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="riboflavin synthase (alpha subunit)" /protein_id="NP_390208.1" /db_xref="EnsemblGenomes-Gn:BSU23270" /db_xref="EnsemblGenomes-Tr:CAB14259" /db_xref="GOA:P16440" /db_xref="InterPro:IPR001783" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR026017" /db_xref="SubtiList:BG10519" /db_xref="UniProtKB/Swiss-Prot:P16440" /translation="MFTGIIEETGTIESMKKAGHAMALTIKCSKILEDVHLGDSIAVN GICLTVTDFTKNQFTVDVMPETVKATSLNDLTKGSKVNLERAMAANGRFGGHFVSGHV DGTAEITRIEEKSNAVYYDLKMDPSLTKTLVLKGSITVDGVSLTIFGLTEDTVTISLI PHTISETIFSEKTIGSKVNIECDMIGKYMYRFLHKANENKTQQTITKAFLSENGF*" /label="ribE CDS" gene complement(1949762..1950409) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /label="ribE gene" CDS complement(1950420..1951505) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /EC_number="1.1.1.193" /EC_number="3.5.4.26" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9068650, 12456892, 17765262, 18986985, 23385458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068650, 12456892, 17765262, 18986985, 23385458; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase" /protein_id="NP_390209.1" /db_xref="EnsemblGenomes-Gn:BSU23280" /db_xref="EnsemblGenomes-Tr:CAB14260" /db_xref="GOA:P17618" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024072" /db_xref="PDB:2B3Z" /db_xref="PDB:2D5N" /db_xref="PDB:3EX8" /db_xref="PDB:4G3M" /db_xref="SubtiList:BG10518" /db_xref="UniProtKB/Swiss-Prot:P17618" /translation="MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLK YGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDP NPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKI ATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVI LDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVL KILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSM KDVPLLQFTDITQIGRDIKLTAKPTKE*" /label="ribD CDS" gene complement(1950420..1951505) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /label="ribD gene" S_feature complement(1951506..1951634) /Source="Nicolas_S_feature" /locus_tag="new_2431344_2431472_c" /HighExp="T0.30H, B60, T1.30H, T2.0H, MG-0.2, T1.0H, S1, T0.0H, LPhT, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S881" misc_RNA complement(1951635..1951779) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /product="flavin riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508, 17693491, 17997835" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508, 17693491, 17997835; Product type n: RNA" /label="fswA RNA" gene complement(1951635..1951779) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /label="fswA gene" promotor_-10 complement(1951796..1951815) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1951806) /Source="Nicolas_upshifts" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1951830..1951837) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1951899..1952243) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390211.1" /db_xref="EnsemblGenomes-Gn:BSU23300" /db_xref="EnsemblGenomes-Tr:CAB14262" /db_xref="SubtiList:BG10516" /db_xref="UniProtKB/Swiss-Prot:P17616" /translation="MGRIKTKITILLVLLLLLAGGYMYINDIELKDVPTAIGQTLSSE EEEYTIQEYKVTKIDGSEYHGVAENGTKIIFNGKKLNQDLSDIKEGDKIKAYFSKSKR IDGLIKVAKVND*" /label="ypuD CDS" gene complement(1951899..1952243) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /label="ypuD gene" downshifts complement(1951914) /Source="Nicolas_upshifts" /id="D1217" /incds=0 /nref=78 /ntot=221 /MaxReadThrough="1.58771" /MaxDrop="5.14851" /score="20.5522057" /energy="-14.7" /TU="NA" /idTUdmin="U1820" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1952275..1952293) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1952288) /Source="Nicolas_upshifts" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1952302..1952307 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1952308..1952314) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1952322..1953244 /Source="Nicolas_S_feature" /locus_tag="new_2432160_2433082" /HighExp="S5, S4, S6, S8, S7, C30, S3, C90, BT, BC" /AntisenseName="sipS" /AntisenseCor="-0.46666993867379197" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S882" upshifts 1952322 /Source="Nicolas_upshifts" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1952323..1952341 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1952329..1952344) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1952332) /Source="Nicolas_upshifts" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1952334..1952400) /Source="Nicolas_S_feature" /locus_tag="new_2432172_2432238_c" /HighExp="Etha, T1.30H, M9-stat, T0.30H, M40t90, T2.30H, MG-0.2, MG 15, HiTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S883" promotor_-35 complement(1952357..1952366) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1952395..1952403) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1952400) /Source="Nicolas_upshifts" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1952417..1952425) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1952478..1953032) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /EC_number="3.4.21.89" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390212.1" /db_xref="EnsemblGenomes-Gn:BSU23310" /db_xref="EnsemblGenomes-Tr:CAB14263" /db_xref="GOA:P28628" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG10515" /db_xref="UniProtKB/Swiss-Prot:P28628" /translation="MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSM YPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYI NGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGL FTKKQIAGTSKFVFYPFNEMRKTN*" /label="sipS CDS" gene complement(1952478..1953032) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /label="sipS gene" downshifts complement(1952488) /Source="Nicolas_upshifts" /id="D1218" /incds=0 /nref=195 /ntot=252 /MaxReadThrough="3.6233" /MaxDrop="7.24702" /score="30.4586783" /energy="-10.9" /TU="U1824" /idTUdmin="U1825" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1953058..1953077) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1953076) /Source="Nicolas_upshifts" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1953078..1953477) /Source="Nicolas_S_feature" /locus_tag="new_2432916_2433315_c" /HighExp="T4.0H, T2.30H, T5.0H, T3.0H, T2.0H, T3.30H, M9-stat, C90, BC, T1.30H" /AntisenseName="ypzC" /AntisenseCor="-0.215992681600812" /AntisenseRegPval="-3.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S884" promotor_-35 complement(1953089..1953095) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1953299..1953535 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390213.1" /db_xref="EnsemblGenomes-Gn:BSU23320" /db_xref="EnsemblGenomes-Tr:CAB14264" /db_xref="SubtiList:BG13765" /db_xref="UniProtKB/Swiss-Prot:O32012" /translation="MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPF FAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL*" /label="ypzC CDS" gene 1953299..1953535 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /label="ypzC gene" CDS complement(1953478..1953684) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097757.1" /db_xref="EnsemblGenomes-Gn:BSU23328" /db_xref="EnsemblGenomes-Tr:CAX52656" /db_xref="InterPro:IPR018652" /db_xref="UniProtKB/Swiss-Prot:C0H447" /translation="MNNKGCIKCGSTEAGQKEIATTGTGLSKLFDVQHNRFLVVYCKN CGYSEFYNKESSTAGNILDLFFGG*" /label="ypzJ CDS" gene complement(1953478..1953684) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /label="ypzJ gene" misc_feature complement(1953717..1953736) /Source="Nicolas_upshift_promotors" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1953739) /Source="Nicolas_upshifts" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="upshifts" CDS complement(1953793..1954047) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="PSEUDO:CAX52657.1" /translation="MSFLVFVLIFLFVILTRRVCKLLHFFVYYRFIPHRAEPCVLYEQ YPSDVAAGYAFGGVWLSLNVLVMELFRFSRRFTKLRNEPN*" /label="ypuC CDS" gene complement(1953793..1954047) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /pseudo /label="ypuC gene" promotor_-35 1953927..1953936 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1953938..1954327) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15849754, 16850406" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="SubtiList:BG10514" /translation="MSYWIGYRLGPAAIQKAFASRGVLLAVIVLTFFWTVFRGQDRKI ELSFLFFLVIGGELYEEGIRRLFHSLHPVHAPLESHVLYPFPSEQTLTAFVIFGFCAY LFVRHSHKTRLQTVAFFCLLSFYSSSG*" /label="ypuC CDS" gene complement(1953938..1954327) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /pseudo /label="ypuC gene" S_feature 1953950..1955021 /Source="Nicolas_S_feature" /locus_tag="new_2433788_2434859" /HighExp="S6, S8, S7, BT, S5, B36, S4, Pyr, G/S, C30" /AntisenseName="ypuC" /AntisenseCor="0.37168085148262697" /AntisenseRegPval="-9.5" /CDS_PredictionProba="0.69113899999999995" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S885" promotor_-10 1953950..1953969 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1953950 /Source="Nicolas_upshifts" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1954305..1954508) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390215.1" /db_xref="EnsemblGenomes-Gn:BSU23340" /db_xref="EnsemblGenomes-Tr:CAB14266" /db_xref="SubtiList:BG10513" /db_xref="UniProtKB/Swiss-Prot:P35151" /translation="MQVLTGLLEQYGYAVLFIVLMLELLALLGPGEFAGVLVFQEKLN WVLSMLAAGLGSCGSEHVVLDRV*" /label="ypuB CDS" gene complement(1954305..1954508) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /label="ypuB gene" CDS 1954917..1955033 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90572.1" /translation="MYMHFESAQDDPITFARKAAAAFRVVKRIDRYLGFRKL*" /label="hypothetical protein CDS" gene 1954917..1955033 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /pseudo /label="gene" downshifts 1954984 /Source="Nicolas_upshifts" /id="D1219" /incds=0 /nref=3 /ntot=18 /MaxReadThrough="-0.179729999999999" /MaxDrop="3.76747" /score="-7.5033349" /energy="-9.1" /TU="NA" /idTUdmin="U1826" /TUdmin=198 /isTUend="FALSE" /label="downshifts" promotor_-35 1955110..1955119 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1955132..1955151 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1955132 /Source="Nicolas_upshifts" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1955174..1955386 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative germination protein" /protein_id="NP_390216.1" /db_xref="EnsemblGenomes-Gn:BSU23350" /db_xref="EnsemblGenomes-Tr:CAB14267" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13766" /db_xref="UniProtKB/Swiss-Prot:O32013" /translation="MIDYPININNVSGNSVINVGGAFMIRPLTLSKSVFGSGGLNTGI VFENNFVSKAKMINHQFTDQNVTKTF*" /label="ypzD CDS" gene 1955174..1955386 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /label="ypzD gene" downshifts 1955380 /Source="Nicolas_upshifts" /id="D1220" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="4.9048" /MaxDrop="3.6863" /score="3.56038753" /energy="-6.9" /TU="U1827" /idTUdmin="U1827" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" downshifts complement(1955522) /Source="Nicolas_upshifts" /id="D1221" /incds=0 /nref=254 /ntot=263 /MaxReadThrough="2.52018" /MaxDrop="8.47213" /score="34.3429406" /energy="-12.4" /TU="NA" /idTUdmin="U1828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1955522..1955953) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8639516, 9063446, 9748346, 25184565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8639516, 9063446, 9748346, 25184565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl isomerase" /protein_id="NP_390217.1" /db_xref="EnsemblGenomes-Gn:BSU23360" /db_xref="EnsemblGenomes-Tr:CAB14268" /db_xref="GOA:P35137" /db_xref="InterPro:IPR002130" /db_xref="InterPro:IPR020892" /db_xref="InterPro:IPR024936" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG10512" /db_xref="UniProtKB/Swiss-Prot:P35137" /translation="MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTF HRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFI VHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG*" /label="ppiB CDS" gene complement(1955522..1955953) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /label="ppiB gene" S_feature complement(1955954..1956040) /Source="Nicolas_S_feature" /locus_tag="new_2435792_2435878_c" /HighExp="dia5, dia15, dia0, Lbexp, LBGtran, C90, Lbtran, HPh, G180, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S886" promotor_-10 complement(1956023..1956042) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1956040) /Source="Nicolas_upshifts" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1956056..1956061) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1956090..1956099 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1956109..1956206 /Source="Nicolas_S_feature" /locus_tag="new_2435947_2436044" /HighExp="Heat, Etha, Salt, dia0, HiTm, T0.30H, B60, Lbexp, T1.0H, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S887" upshifts 1956109 /Source="Nicolas_upshifts" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1956112..1956127 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1956207..1957079 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17434969, 18179421, 24706874; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390218.1" /db_xref="EnsemblGenomes-Gn:BSU23370" /db_xref="EnsemblGenomes-Tr:CAB14269" /db_xref="InterPro:IPR009343" /db_xref="SubtiList:BG10511" /db_xref="UniProtKB/Swiss-Prot:P31847" /translation="MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDK QKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVE THNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISED VKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDL NVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVID FFVSIWNAIVSIFK*" /label="ypuA CDS" gene 1956207..1957079 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /label="ypuA gene" downshifts 1956986 /Source="Nicolas_upshifts" /id="D1222" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="5.9994" /MaxDrop="4.15288" /score="27.7277161" /energy="-12.7" /TU="U1829" /idTUdmin="U1829" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 1957052 /Source="Nicolas_upshifts" /id="D1223" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="1.98749" /MaxDrop="5.95835" /score="27.7277161" /energy="-12.7" /TU="NA" /idTUdmin="U1829" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1957109..1958428) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /EC_number="4.1.1.20" /experiment="publication(s) with functional evidences, PMID:9044297, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9044297, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-2,6-diaminopimelate decarboxylase" /protein_id="NP_390219.1" /db_xref="EnsemblGenomes-Gn:BSU23380" /db_xref="EnsemblGenomes-Tr:CAB14270" /db_xref="GOA:P23630" /db_xref="InterPro:IPR000183" /db_xref="InterPro:IPR002986" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR022643" /db_xref="InterPro:IPR022644" /db_xref="InterPro:IPR022653" /db_xref="InterPro:IPR022657" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10510" /db_xref="UniProtKB/Swiss-Prot:P23630" /translation="MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRER AKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPA ERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGF VLAAEKIFKKLDEWRDSYSFVSKVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKEN ASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALY QAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGY SMANNYNRIPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ*" /label="lysA CDS" gene complement(1957109..1958428) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /label="lysA gene" downshifts complement(1957129) /Source="Nicolas_upshifts" /id="D1224" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.99445" /MaxDrop="5.13504" /score="28.6775009" /energy="-12.7" /TU="NA" /idTUdmin="U1830" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1958429..1958493) /Source="Nicolas_S_feature" /locus_tag="new_2438267_2438331_c" /HighExp="C90, HiOs, BMM, GM 120, GM 25, MG-0.2, GM 15, GM-0.2, MG t5, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S888" promotor_-10 complement(1958489..1958508) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1958493) /Source="Nicolas_upshifts" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1958523..1958530) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1958534..1959152) /gene="spoVAF" /locus_tag="PG10_5'_ext_BSU_23390" /old_locus_tag="BSU_23390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AF" /protein_id="NP_390220.2" /db_xref="EnsemblGenomes-Gn:BSU23390" /db_xref="EnsemblGenomes-Tr:CAB14271" /db_xref="GOA:P31845" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10508" /db_xref="UniProtKB/Swiss-Prot:P31845" /modified_by="User" /translation="MTTSSGKIFRYSCFYFISSDLVSLCASA*SAPGQHEIYRFK*RY AYPDHPADIFS*LRNRVSQNGCHSHTDGFIDSNGFNCRCSDRADCD*GRPFFS*GDSV RLTCGDWNLYDA*L*IKLGKQNEPSCPHDTRCFISYKRARHRIYSANYCHGKHQIPSD TVLMAADSL*RKGAVAGSCPHSETWRKSKTQHRSPQKSLKAAYQFI" /label="PG10_5'_ext_BSU_23390" gene complement(1958534..1959152) /gene="PG10_5'_ext_BSU_23390" /locus_tag="PG10_pseudo_BSU_23390" /old_locus_tag="BSU_23390" /modified_by="User" /label="PG10_5'_ext_BSU_23390" SCAR join(1959138,1959145) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs23" N_region 1959139..1959144 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs23" S_feature complement(<1959145..1959161) /Source="Nicolas_S_feature" /locus_tag="new_2445036_2445093_c" /HighExp="S4, S3, S7, S5, S8, S6, T5.0H, BT, LoTm, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.859" /TUlongSig="NA" /TUlongPSig="NA" /label="S889" CDS complement(1959162..1960331) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /EC_number="3.4.16.4" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8021191, 8936302, 9864321, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021191, 8936302, 9864321, 19189487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicilin binding protein)" /protein_id="NP_390229.1" /db_xref="EnsemblGenomes-Gn:BSU23480" /db_xref="EnsemblGenomes-Tr:CAB14280" /db_xref="GOA:P38422" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10295" /db_xref="UniProtKB/Swiss-Prot:P38422" /translation="MKRLLSTLLIGIMLLTFAPSAFAKQDGKRTSELAHEAKSAVLIE RDTGKVLYNKNSNERLAPASMTKIMTMLLIMEALDKGKIKMSDKVRTSEHAASMGGSQ IFLEPGEEMTVKEMLKGIAIASGNDASVAMAEFISGSEEEFVKKMNKKAKELGLKNTS FKNPTGLTEEGHYSSAYDMAIMAKELLKYESITKFTGTYEDYLRENTDKKFWLVNTNR LIKFYPGVDGVKTGYTGEAKYCLTASAKKGNMRAIAVVFGASTPKERNAQVTKMLDFA FSQYETHPLYKRNQTVAKVKVKKGKQKFIELTTSEPISILTKKGEDMNDVKKEIKMKD NISAPIQKGQELGTLVLKKDGEVLAESPVAAKEDMKKAGFITFLKRTMGDWTKFK*" /label="dacF CDS" gene complement(1959162..1960331) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /label="dacF gene" promotor_-10 complement(1960360..1960371) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1960375) /Source="Nicolas_upshifts" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1960385..1960391) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1960477) /Source="Nicolas_upshifts" /id="D1226" /incds=0 /nref=243 /ntot=267 /MaxReadThrough="0.87114" /MaxDrop="7.5376" /score="26.8559416" /energy="-16.7" /TU="NA" /idTUdmin="U1836" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1960486..1961301) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 15530033, 21279421, 21543875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 15530033, 21279421, 21543875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_390230.1" /db_xref="EnsemblGenomes-Gn:BSU23490" /db_xref="EnsemblGenomes-Tr:CAB14281" /db_xref="GOA:P46354" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR011268" /db_xref="InterPro:IPR011270" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG11330" /db_xref="UniProtKB/Swiss-Prot:P46354" /translation="MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLK YEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALG VEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDK DLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVA NHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE*" /label="pupG CDS" gene complement(1960486..1961301) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /label="pupG gene" CDS complement(1961314..1962498) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /EC_number="5.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,5-phosphopentomutase" /protein_id="NP_390231.2" /db_xref="EnsemblGenomes-Gn:BSU23500" /db_xref="EnsemblGenomes-Tr:CAB14282" /db_xref="GOA:P46353" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR010045" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR024052" /db_xref="SubtiList:BG11331" /db_xref="UniProtKB/Swiss-Prot:P46353" /translation="MPAYKYNRVFLIVMDSVGIGEAPDAADFNDEGAHTLGHIAEHMN GLHMPNMAKLGLGLIEDIKGVEKTEHPLAYYGKMQEASNGKDTMTGHWEIMGLYIDKP FKVFPEGFPDELLQELEKRSGRKIIGNKPASGTAILDELGQEHMETGALIVYTSADSV LQIAAHEEVVPLEELYRICETARELTLDPKYMVGRIIARPFVGEPGQFKRTPNRHDYA LKPFDRTVMNELKDCGLDVISIGKISDIYDGEGITSSRRTVSNMDGMDKVIDTLGEDF TGLSFANLVDFDALFGHRRDPEGYGRALEEFDARLPEVFEKMREDDLLIITADHGNDP IHHGTDHTREYVPILAYSKKHKKAQMLPLADTFADIGATIADNFQTNKPKYGKSFLSL LQ*" /label="deoB CDS" gene complement(1961314..1962498) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /label="deoB gene" promotor_-10 complement(1962547..1962566) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1962565) /Source="Nicolas_upshifts" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1962567..1962658) /Source="Nicolas_S_feature" /locus_tag="new_2448499_2448590_c" /HighExp="S3, S4, M0t90, G180, S7, S8, Glucon, G135, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigEF, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S890" promotor_-35 complement(1962582..1962589) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1962659..1963549) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_390232.2" /db_xref="EnsemblGenomes-Gn:BSU23510" /db_xref="EnsemblGenomes-Tr:CAB14283" /db_xref="GOA:P46352" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011932" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG11332" /db_xref="UniProtKB/Swiss-Prot:P46352" /translation="MKDQIKDFIHYVMVERGLSQNTIVSYERDLKSYSLYLTETLHVT DWNHVTRIHIIQYLKHLKDSGKSGKTSARHLASIRSFHQFLLREKVTDKDPSVHIETQ KTERALPKVLALNEVERLLDTPKLTSPFGYRDKAMLELLYATGIRVSEMIELKTADVH LSMGFIRCFGKGRKERIVPIGEAAASAIEEYMTKARGKLLKNNVSDALFLNHHGKQIS RQGFWKNLKKIALEAGIKKELTPHTLRHSFATHLLENGADLRAVQEMLGHADISTTQI YTHVTKTRLKDVYKQFHPRA*" /label="ripX CDS" gene complement(1962659..1963549) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /label="ripX gene" CDS complement(1963557..1963784) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097760.1" /db_xref="EnsemblGenomes-Gn:BSU23519" /db_xref="EnsemblGenomes-Tr:CAX52660" /db_xref="GOA:C0H451" /db_xref="InterPro:IPR025321" /db_xref="UniProtKB/Swiss-Prot:C0H451" /translation="MGRFLKTAVDALKVFILFTGFTALFYYAMIWVNQEYENYHRYDK PEGSAVKVVEMDQDEKGGWFDRLIFFYQNGE*" /label="yqzK CDS" gene complement(1963557..1963784) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /label="yqzK gene" promotor_-10 complement(1963687..1963706) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1963698) /Source="Nicolas_upshifts" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1963720..1963727) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1963777) /Source="Nicolas_upshifts" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1963786..1963804) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1963814..1963832) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1963820..1963826) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1963827) /Source="Nicolas_upshifts" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1963849..1963854) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1963909) /Source="Nicolas_upshifts" /id="D1227" /incds=0 /nref=159 /ntot=251 /MaxReadThrough="4.06128" /MaxDrop="5.73495" /score="5.40881961" /energy="-8.1" /TU="U1840" /idTUdmin="U1841" /TUdmin=506 /isTUend="FALSE" /label="downshifts" CDS complement(1963909..1964358) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for iron transport andmetabolism" /protein_id="NP_390233.2" /db_xref="EnsemblGenomes-Gn:BSU23520" /db_xref="EnsemblGenomes-Tr:CAB14284" /db_xref="GOA:P54574" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11766" /db_xref="UniProtKB/Swiss-Prot:P54574" /translation="MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVY LLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCME CGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE*" /label="fur CDS" gene complement(1963909..1964358) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /label="fur gene" promotor_-10 complement(1964382..1964401) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-10" upshifts complement(1964392) /Source="Nicolas_upshifts" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="upshifts" S_feature complement(1964394..1964470) /Source="Nicolas_S_feature" /locus_tag="new_2450326_2450402_c" /HighExp="S3, S4, S5, BT, LoTm, M9-stat, T5.0H, T3.30H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S891" promotor_-35 complement(1964417..1964421) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-35" CDS complement(1964471..1965115) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17376078, 17824930, 20382772, 23859254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17376078, 17824930, 20382772, 23859254; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="autolysin component for dissolution of the septal cell wall (stage II sporulation)" /protein_id="NP_390234.1" /db_xref="EnsemblGenomes-Gn:BSU23530" /db_xref="EnsemblGenomes-Tr:CAB14285" /db_xref="GOA:P37873" /db_xref="InterPro:IPR002798" /db_xref="InterPro:IPR014196" /db_xref="SubtiList:BG10768" /db_xref="UniProtKB/Swiss-Prot:P37873" /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTI SQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFI MIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLI RQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF*" /label="spoIIM CDS" gene complement(1964471..1965115) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /label="spoIIM gene" promotor_-10 complement(1965146..1965164) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-10" upshifts complement(1965163) /Source="Nicolas_upshifts" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="upshifts" promotor_-35 complement(1965179..1965184) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-35" CDS complement(1965216..1965431) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390235.1" /db_xref="EnsemblGenomes-Gn:BSU23540" /db_xref="EnsemblGenomes-Tr:CAB14286" /db_xref="SubtiList:BG11765" /db_xref="UniProtKB/Swiss-Prot:P54573" /translation="MAKSQAKKKRGHRLRNGGRDVLLSRGSTPSFSTHGRMTKSKKEI LNKRKHKNPYDHTAVDDKDFFVPQKAA*" /label="yqkK CDS" gene complement(1965216..1965431) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /label="yqkK gene" downshifts complement(1965296) /Source="Nicolas_upshifts" /id="D1228" /incds=1 /nref=17 /ntot=130 /MaxReadThrough="0.857610000000001" /MaxDrop="3.7055" /score="1.77181315" /energy="-9.8" /TU="NA" /idTUdmin="U1842" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1965531..1966850) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 23136871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catabolic NAD-dependent malic enzyme (conversionof malate into pyruvate)" /protein_id="NP_390236.1" /db_xref="EnsemblGenomes-Gn:BSU23550" /db_xref="EnsemblGenomes-Tr:CAB14287" /db_xref="GOA:P54572" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11764" /db_xref="UniProtKB/Swiss-Prot:P54572" /translation="MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVG PNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPI RSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAG MPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFE IEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAIC RMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPA FVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEI NHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK*" /label="mleA CDS" gene complement(1965531..1966850) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /label="mleA gene" downshifts complement(1965538) /Source="Nicolas_upshifts" /id="D1229" /incds=0 /nref=29 /ntot=84 /MaxReadThrough="3.50516" /MaxDrop="5.65279" /score="42.1653011" /energy="-15.2" /TU="U1842,U1843" /idTUdmin="U1842" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" CDS complement(1966868..1968274) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10903309, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10903309, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="malate-H+/Na+-lactate antiporter" /protein_id="NP_390237.1" /db_xref="EnsemblGenomes-Gn:BSU23560" /db_xref="EnsemblGenomes-Tr:CAB14288" /db_xref="GOA:P54571" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG11763" /db_xref="UniProtKB/Swiss-Prot:P54571" /translation="MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFI AMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLE FIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGA YFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNI DLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQ GMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGV LKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR RVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYT GKFIWYTKNNTVKAEKLG*" /label="mleN CDS" gene complement(1966868..1968274) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /label="mleN gene" promotor_-10 complement(1968322..1968341) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1968331) /Source="Nicolas_upshifts" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1968333..1968414) /Source="Nicolas_S_feature" /locus_tag="new_2454265_2454346_c" /HighExp="S0, dia0, dia5, Lbexp, G150, Oxctl, G135, Mt0, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S892" promotor_-35 complement(1968356..1968363) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1968415..1969842) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /EC_number="4.3.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-aspartase (aspartate ammonia lyase)" /protein_id="NP_390238.2" /db_xref="EnsemblGenomes-Gn:BSU23570" /db_xref="EnsemblGenomes-Tr:CAB14289" /db_xref="GOA:P26899" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004708" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10301" /db_xref="UniProtKB/Swiss-Prot:P26899" /translation="MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKI HEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGA GTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLL EKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRI KQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDA YTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAE LINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLK GIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTE EELDIILNPYEMTKPGIAGKELLEK*" /label="ansB CDS" gene complement(1968415..1969842) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /label="ansB gene" CDS complement(1969887..1970876) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /EC_number="3.5.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029, 11914346, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029, 11914346, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported L-asparaginase" /protein_id="NP_390239.1" /db_xref="EnsemblGenomes-Gn:BSU23580" /db_xref="EnsemblGenomes-Tr:CAB14290" /db_xref="GOA:P26900" /db_xref="InterPro:IPR006033" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG10300" /db_xref="UniProtKB/Swiss-Prot:P26900" /translation="MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTM ETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHA KKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTK SYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEM FDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIY EVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL*" /label="ansA CDS" gene complement(1969887..1970876) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /label="ansA gene" S_feature complement(1970877..1970956) /Source="Nicolas_S_feature" /locus_tag="new_2456809_2456888_c" /HighExp="dia0, Lbexp, G150, Oxctl, dia5, LBGexp, Paraq, C30, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S893" promotor_-10 complement(1970938..1970957) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1970956) /Source="Nicolas_upshifts" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1970958..1971278) /Source="Nicolas_S_feature" /locus_tag="new_2456890_2457210_c" /HighExp="LBGstat, S5, G135, S8, S6, LBGtran, G180, G150, LoTm, LBGexp" /AntisenseName="ansR" /AntisenseCor="0.23077291929287899" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S894" promotor_-35 complement(1970972..1970979) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1970997..1971004 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1971017..1971036 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1971019 /Source="Nicolas_upshifts" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="upshifts" CDS 1971058..1971408 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of ansAB (Xre family)" /protein_id="NP_390240.1" /db_xref="EnsemblGenomes-Gn:BSU23590" /db_xref="EnsemblGenomes-Tr:CAB14291" /db_xref="GOA:Q07683" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG10299" /db_xref="UniProtKB/Swiss-Prot:Q07683" /translation="MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLE ALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLI TFIRTKRKVQEELS*" /label="ansR CDS" gene 1971058..1971408 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /label="ansR gene" S_feature complement(1971280..1971416) /Source="Nicolas_S_feature" /locus_tag="new_2457212_2457348_c" /HighExp="LBGstat, S8, S6, S7, S5, ferm, nit, LBGtran, BT, LPhT" /AntisenseName="ansR" /AntisenseCor="-0.22421651781702501" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S895" downshifts complement(1971323) /Source="Nicolas_upshifts" /id="D1230" /incds=1 /nref=4 /ntot=116 /MaxReadThrough="3.90926" /MaxDrop="4.76642" /score="10.2434094" /energy="-23.6" /TU="U1847" /idTUdmin="U1845" /TUdmin=1451 /isTUend="FALSE" /label="downshifts" CDS complement(1971417..1972580) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleotide binding protein" /protein_id="NP_390241.2" /db_xref="EnsemblGenomes-Gn:BSU23600" /db_xref="EnsemblGenomes-Tr:CAB14292" /db_xref="GOA:P38423" /db_xref="InterPro:IPR005287" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG11073" /db_xref="UniProtKB/Swiss-Prot:P38423" /translation="MKKIYADLHIHIGRTFTGRAVKITGAKTLTLDRILVEASEHKGI ELLGIIDCHSPEVILELEEGISSGKYRELDGGGIRYRSTTLLLGSELEIYDEACSGPI HVLVFMPTLADMKQFSNWLSARLKNIHLSSQRIYETGLNLQKKVQDMGGLFIPAHIFT PHKSLYGKGVKSSLTEVFDPSMIDAVELGLSCDTDMASHVSQLNPYPFLTNSDAHSLG KIGREYNELYVQSADFTEFALALKGQDDRKIIANYGLDPLLGKYYQTACEACGEPAVS GETACANCGKARFTKGVSDRLRELSDQLEVRVPRPRYVHQIPLQFVPGVGPKTLDKLK KAFGTEMAVLHEAAEEDLARVVPPKTAALIVKARSGKLELKAGGGGTYGKIKP*" /label="yqxK CDS" gene complement(1971417..1972580) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /label="yqxK gene" CDS complement(1972577..1973134) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /EC_number="3.1.7.1" /EC_number="3.6.1.13" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10542272, 17693564, 21638333, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl pyrophosphate and dimethylallyl pyrophosphate diphosphatase (moonlighting ADP-ribose pyrophosphatase)" /protein_id="NP_390242.1" /db_xref="EnsemblGenomes-Gn:BSU23610" /db_xref="EnsemblGenomes-Tr:CAB14293" /db_xref="GOA:P54570" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11762" /db_xref="UniProtKB/Swiss-Prot:P54570" /translation="MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPG AVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAK KLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVES REVYDAKTAYAIQYLQLKEALQAQK*" /label="nudF CDS" gene complement(1972577..1973134) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /label="nudF gene" promotor_no_box complement(1973064..1973164) /Source="Nicolas_upshift_promotors" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1973104) /Source="Nicolas_upshifts" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1973148..1973153 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1973169..1973187 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1973171..1973185) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-10" upshifts 1973175 /Source="Nicolas_upshifts" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="upshifts" S_feature 1973182..1973356 /Source="Nicolas_S_feature" /locus_tag="new_2459114_2459288" /HighExp="S4, S5, S3, S7, S6, LoTm, BT, T5.0H, G/S, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99962399999999996" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S896" promotor_-35 complement(1973187..1973190) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-35" upshifts complement(1973190) /Source="Nicolas_upshifts" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="upshifts" CDS 1973209..1973331 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /function="15.1: Cell division" /experiment="publication(s) with functional evidences, PMID:18284588, 23237472, 25848052, 27752253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18284588, 23237472, 25848052, 27752253; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="YP_009513976.1" /db_xref="EnsemblGenomes-Gn:BSU23616" /db_xref="EnsemblGenomes-Tr:CCQ48600" /db_xref="GOA:L8EBJ9" /db_xref="InterPro:IPR025177" /db_xref="PDB:2MRW" /db_xref="PDB:4U39" /db_xref="UniProtKB/TrEMBL:L8EBJ9" /translation="MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP*" /label="mciZ CDS" gene 1973209..1973331 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /label="mciZ gene" promotor_-35 1973332..1973339 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1973353..1973372 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1973358 /Source="Nicolas_upshifts" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="upshifts" CDS 1973394..1974314 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /EC_number="1.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9643546, 15317791, 16242712, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent aldo-keto reductase (acts on 4-hydroxy-2,3-trans-nonenal)" /protein_id="NP_390243.1" /db_xref="EnsemblGenomes-Gn:BSU23620" /db_xref="EnsemblGenomes-Tr:CAB14294" /db_xref="GOA:P54569" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11761" /db_xref="UniProtKB/Swiss-Prot:P54569" /translation="MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINY LDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVK KSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYV KKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQ NGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENI QAANARRLTEEEIKALQSHTKQDIYKAHRS*" /label="yqkF CDS" gene 1973394..1974314 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /label="yqkF gene" downshifts 1974303 /Source="Nicolas_upshifts" /id="D1231" /incds=0 /nref=186 /ntot=248 /MaxReadThrough="1.49159" /MaxDrop="5.81013" /score="18.6018806" /energy="-14.8" /TU="NA" /idTUdmin="U1846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1974346..1974570) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390244.1" /db_xref="EnsemblGenomes-Gn:BSU23630" /db_xref="EnsemblGenomes-Tr:CAB14295" /db_xref="InterPro:IPR024980" /db_xref="SubtiList:BG11760" /db_xref="UniProtKB/Swiss-Prot:P54568" /translation="MKKQKSIDKHQLKDGLQSDIKAKLMEMKSQLKEEDEKRQKREKA EQIRKKKEIEKNKSFEELLNESQMDWHQYK*" /label="yqkE CDS" gene complement(1974346..1974570) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /label="yqkE gene" downshifts complement(1974403) /Source="Nicolas_upshifts" /id="D1232" /incds=0 /nref=19 /ntot=195 /MaxReadThrough="0.59953" /MaxDrop="5.9087" /score="15.8160537" /energy="-13" /TU="NA" /idTUdmin="U1849" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1974593..1974612) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1974600) /Source="Nicolas_upshifts" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1974627..1974634) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1974649..1974656 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1974671..1974690 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1974678 /Source="Nicolas_upshifts" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="upshifts" CDS 1974732..1975649 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390245.1" /db_xref="EnsemblGenomes-Gn:BSU23640" /db_xref="EnsemblGenomes-Tr:CAB14296" /db_xref="GOA:P54567" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11759" /db_xref="UniProtKB/Swiss-Prot:P54567" /translation="MKKILLAIGALVTAVIAIGIVFSHMILFIKKKTDEDIIKRETDN GHDVFESFEQMEKTAFVIPSAYGYDIKGYHVAPHDTPNTIIICHGVTMNVLNSLKYMH LFLDLGWNVLIYDHRRHGQSGGKTTSYGFYEKDDLNKVVSLLKNKTNHRGLIGIHGES MGAVTALLYAGAHCSDGADFYIADCPFACFDEQLAYRLRAEYRLPSWPLLPIADFFLK LRGGYRAREVSPLAVIDKIEKPVLFIHSKDDDYIPVSSTERLYEKKRGPKALYIAENG EHAMSYTKNRHTYRKTVQEFLDNMNDSTE*" /label="yqkD CDS" gene 1974732..1975649 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /label="yqkD gene" downshifts 1975624 /Source="Nicolas_upshifts" /id="D1233" /incds=0 /nref=27 /ntot=171 /MaxReadThrough="2.02201" /MaxDrop="3.99393" /score="14.106821" /energy="-11.8" /TU="NA" /idTUdmin="U1850" /TUdmin=594 /isTUend="FALSE" /label="downshifts" CDS complement(1975689..1975928) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390246.1" /db_xref="EnsemblGenomes-Gn:BSU23650" /db_xref="EnsemblGenomes-Tr:CAB14297" /db_xref="InterPro:IPR020157" /db_xref="SubtiList:BG11758" /db_xref="UniProtKB/Swiss-Prot:P54566" /translation="MEQKLKAMKNTAQNKTWVSFLNQNHPYTLLHWSIGGAESIKKDV WLLQDEMTFETQEFTTIDLAIEWIRENMDGITDVL*" /label="yqkC CDS" gene complement(1975689..1975928) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /label="yqkC gene" downshifts complement(1975700) /Source="Nicolas_upshifts" /id="D1234" /incds=0 /nref=215 /ntot=269 /MaxReadThrough="3.31829" /MaxDrop="6.35785" /score="16.3526162" /energy="-11.2" /TU="NA" /idTUdmin="U1851" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1975941..1976264) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390247.1" /db_xref="EnsemblGenomes-Gn:BSU23660" /db_xref="EnsemblGenomes-Tr:CAB14298" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11757" /db_xref="UniProtKB/Swiss-Prot:P54565" /translation="MNIHVTDAAKQALQQAFDANPGKKAQLRYDAEGCGCAVSGVPTI WLAEELTGQCEQLETNGIPLYIQSSQKVFFDDQMTIDYNEKAKTLALKSPAEMLSPRM SILVK*" /label="yqkB CDS" gene complement(1975941..1976264) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /label="yqkB gene" promotor_-10 complement(1976007..1976026) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1976008) /Source="Nicolas_upshifts" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1976040..1976047) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1976261..1977292) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390248.1" /db_xref="EnsemblGenomes-Gn:BSU23670" /db_xref="EnsemblGenomes-Tr:CAB14299" /db_xref="GOA:P54564" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR007344" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11756" /db_xref="UniProtKB/Swiss-Prot:P54564" /translation="MIEFLQHKEATIAREILAVQIPAYIKETEIIGFDGIPALQEKVK DIQASHERFAGYRKNGKLIGVISYEKNMHYLTICRLVVHPDGFRKGIGRALLQFVIDH NEDAEKIEVVTAENNTPAVSLYTQAGFQKAETVKAAQGLLLSVFHLYPKRKVEIILYN EKWAECFDEEKERLKLVFGPEIIAIHHIGSTSIPNMAAKPIIDMLIEVRSIEAVSQFD EQMKANGYTPKGENGIAGRRYFQKGGNKRTHHVHMYEQGNPAIERHLLFRDYLRAHPN IAKEYAVLKKQLAAQHPDSINQYIQGKDEWIKTAEENAKRWKKGRNNANGSIVCYNSE NDENGGFTL*" /label="yqkA CDS" gene complement(1976261..1977292) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /label="yqkA gene" promotor_-10 complement(1976288..1976307) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1976295) /Source="Nicolas_upshifts" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1976318..1976325) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1977285..1977629) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradation enzyme (oxygenase)" /protein_id="NP_390249.1" /db_xref="EnsemblGenomes-Gn:BSU23680" /db_xref="EnsemblGenomes-Tr:CAB14300" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:2GO8" /db_xref="SubtiList:BG11755" /db_xref="UniProtKB/Swiss-Prot:P54563" /translation="MMDFLSKTPEPPYYAVIFSSVKSENDTGYGETAERMVSLAADQP GFLGVESVREADGRGITVSYWDSMDAINHWRHHTEHQAAKEKGRSVWYESYAVRVAKV DRQRLFQENTND*" /label="yqjZ CDS" gene complement(1977285..1977629) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /label="yqjZ gene" CDS complement(1977639..1978109) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390250.1" /db_xref="EnsemblGenomes-Gn:BSU23690" /db_xref="EnsemblGenomes-Tr:CAB14301" /db_xref="GOA:P54562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017255" /db_xref="PDB:1MK4" /db_xref="SubtiList:BG11754" /db_xref="UniProtKB/Swiss-Prot:P54562" /translation="MDIRTITSSDYEMVTSVLNEWWGGRQLKEKLPRLFFEHFQDTSF ITSEHNSMTGFLIGFQSQSDPETAYIHFSGVHPDFRKMQIGKQLYDVFIETVKQRGCT RVKCVTSPVNKVSIAYHTKLGFDIEKGTKTVNGISVFANYDGPGQDRVLFVKNI*" /label="yqjY CDS" gene complement(1977639..1978109) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /label="yqjY gene" S_feature complement(1978110..1978186) /Source="Nicolas_S_feature" /locus_tag="new_2464042_2464118_c" /HighExp="SMM, T-4.40H, MG 150, M9-tran, GM 90, T-3.40H, GM-0.2, M9-exp, GM 120, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigEF" /TUlongPSig="0.776" /label="S897" downshifts 1978110 /Source="Nicolas_upshifts" /id="D1235" /incds=0 /nref=8 /ntot=121 /MaxReadThrough="0.87367" /MaxDrop="3.61005" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1978161..1978180) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1978186) /Source="Nicolas_upshifts" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1978188..1978294) /Source="Nicolas_S_feature" /locus_tag="new_2464120_2464226_c" /HighExp="M40t90, S4, M40t45, S6, H2O2, S5, S3, S8, S7, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.776" /TUlongSig="NA" /TUlongPSig="NA" /label="S898" promotor_-35 complement(1978195..1978202) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1978295..1978633) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390251.1" /db_xref="EnsemblGenomes-Gn:BSU23700" /db_xref="EnsemblGenomes-Tr:CAB14302" /db_xref="GOA:P54561" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG11753" /db_xref="UniProtKB/Swiss-Prot:P54561" /translation="MNDHLKRGNLLWEGSRMFLPEHKQSLLERKRLKQKLQKPILDPD KLEEMNQTLCAAMEFAQDITVSCFQDGEIVCCTGKICRYEEFEKAVWIKGDEDQLYKL KLDQVLDIVL*" /label="yqjX CDS" gene complement(1978295..1978633) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /label="yqjX gene" CDS complement(1978630..1979868) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /EC_number="2.7.7.7" /function="16.5: Explore" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Y family DNA polymerase V bypassing lesions during replication" /protein_id="NP_390252.1" /db_xref="EnsemblGenomes-Gn:BSU23710" /db_xref="EnsemblGenomes-Tr:CAB14303" /db_xref="GOA:P54560" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11752" /db_xref="UniProtKB/Swiss-Prot:P54560" /translation="MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGV VLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVE PYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNF AKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLL KKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLEL SEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFL TFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAA SLTAAGQAFERAAKIGGHYK*" /label="polYB CDS" gene complement(1978630..1979868) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /label="polYB gene" misc_feature 1978792..1978793 /Source="Nicolas_upshift_promotors" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1978803 /Source="Nicolas_upshifts" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1978858 /Source="Nicolas_upshifts" /id="D1236" /incds=1 /nref=2 /ntot=2 /MaxReadThrough="-0.14995" /MaxDrop="4.86715" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1979893..1979911) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-10" upshifts complement(1979902) /Source="Nicolas_upshifts" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="upshifts" promotor_-35 complement(1979928..1979933) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-35" promotor_-35 1979973..1979976 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1979991..1980010 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1980000 /Source="Nicolas_upshifts" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="upshifts" CDS 1980034..1980240 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390253.1" /db_xref="EnsemblGenomes-Gn:BSU23720" /db_xref="EnsemblGenomes-Tr:CAB14304" /db_xref="InterPro:IPR025546" /db_xref="SubtiList:BG13774" /db_xref="UniProtKB/Swiss-Prot:O32014" /translation="MEKFVEKMLGQALRQYGRNVAIDPLSPYEKQSLKAALQERRNEE PDEDLHAHIEDIIYDYVTNQGLFS*" /label="yqzH CDS" gene 1980034..1980240 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /label="yqzH gene" promotor_-35 1980723..1980726 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1980741..1980760 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1980757 /Source="Nicolas_upshifts" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="upshifts" CDS 1980789..1982021 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390254.2" /db_xref="EnsemblGenomes-Gn:BSU23730" /db_xref="EnsemblGenomes-Tr:CAB14305" /db_xref="GOA:P54559" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11751" /db_xref="UniProtKB/Swiss-Prot:P54559" /translation="MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASA SYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFF VVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSS QSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIAL VGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKR FSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKP GLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAY RQMKMETTKHRSRLEKPL*" /label="yqjV CDS" gene 1980789..1982021 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /label="yqjV gene" CDS 1981868..1982230 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390255.2" /db_xref="EnsemblGenomes-Gn:BSU23740" /db_xref="EnsemblGenomes-Tr:CAB14306" /db_xref="GOA:P54558" /db_xref="SubtiList:BG11750" /db_xref="UniProtKB/Swiss-Prot:P54558" /translation="MYRPVWRWPADLYFFCPERHYPARPAIFSVRLSANENGDHKTPF PSGKAALNKKRKRMNLSRKHEVKNMNIGDVMFQLFVFIIFAAVVFAAVTGFKYAKNRK AQLDRIEKKLNSLSEDHD*" /label="yqjU CDS" gene 1981868..1982230 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /label="yqjU gene" S_feature complement(1982047..1982226) /Source="Nicolas_S_feature" /locus_tag="new_2467979_2468158_c" /HighExp="Sw, BC, C90, C30, M0t90, BI, Lbtran, Lbstat, M40t45, G135" /AntisenseName="yqjU" /AntisenseCor="-0.38632421151235602" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S899" downshifts complement(1982080) /Source="Nicolas_upshifts" /id="D1237" /incds=0 /nref=59 /ntot=226 /MaxReadThrough="1.66997" /MaxDrop="4.81479" /score="21.7095422" /energy="-11.4" /TU="NA" /idTUdmin="U1858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1982227..1982613) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390256.1" /db_xref="EnsemblGenomes-Gn:BSU23750" /db_xref="EnsemblGenomes-Tr:CAB14307" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11749" /db_xref="UniProtKB/Swiss-Prot:P54557" /translation="MHHIELYVSDLEASRRFWGWFLKELGYKEYQKWSSGISWKKDRF YLVIVQAKEPFLEPEYHRCRVGLNHLAFHAESKLQVDQMTEKLTAKGYRVLYRDRHPF AGGDGHYAVFCEDPDRIKVELVAPSC*" /label="yqjT CDS" gene complement(1982227..1982613) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /label="yqjT gene" CDS complement(1982617..1983576) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328157, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328157, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase" /protein_id="NP_390257.2" /db_xref="EnsemblGenomes-Gn:BSU23760" /db_xref="EnsemblGenomes-Tr:CAB14308" /db_xref="GOA:P54556" /db_xref="InterPro:IPR004566" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11748" /db_xref="UniProtKB/Swiss-Prot:P54556" /translation="MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLND YLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGK STTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPR IFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMA ASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV*" /label="coaA CDS" gene complement(1982617..1983576) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /label="coaA gene" S_feature complement(1983577..1983647) /Source="Nicolas_S_feature" /locus_tag="new_2469509_2469579_c" /HighExp="LBGtran, dia15, Diami, C90, H2O2, M0t45, G135, Lbtran, HiTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S900" CDS complement(1983648..1984994) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /EC_number="4.3.1.18" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-serine ammonia-lyase" /protein_id="NP_390258.2" /db_xref="EnsemblGenomes-Gn:BSU23770" /db_xref="EnsemblGenomes-Tr:CAB14309" /db_xref="GOA:P54555" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011780" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG11747" /db_xref="UniProtKB/Swiss-Prot:P54555" /translation="MSVHSEVLHALLKDPFIQKLIDAEPVFWANSGKKEGPLPRADEW ATEIAEAEKRMQRFAPYIAEVFPETKGAKGIIESPLFEVQHMKGKLEAAYQQPFPGRW LLKCDHELPISGSIKARGGIYEVLKYAENLALQEGMLQETDDYRILQEERFTGFFSRY SIAVGSTGNLGLSIGIIGAALGFRVTVHMSADAKQWKKDLLRQKGVTVMEYETDYSEA VNEGRRQAEQDPFCYFIDDEHSRQLFLGYAVAASRLKTQLDCMNIKPSLETPLFVYLP CGVGGGPGGVAFGLKLLYGDDVHVFFAEPTHSPCMLLGLYSGLHEKISVQDIGLDNQT AADGLAVGRPSGFVGKLIEPLLSGCYTVEDNTLYTLLHMLAVSEDKYLEPSALAGMFG PVQLFSTEEGRRYAQKYKMEHAVHVVWGTGGSMVPKDEMAAYNRIGADLLKKRNEK*" /label="dsdA CDS" gene complement(1983648..1984994) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /label="dsdA gene" S_feature complement(1984995..1985069) /Source="Nicolas_S_feature" /locus_tag="new_2470927_2471001_c" /HighExp="C90, LBGtran, Diami, dia15, H2O2, dia5, G150, MG 15, GM-0.2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S901" CDS complement(1985070..1985849) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metabolite dehydrogenase, NAD-binding" /protein_id="NP_390259.1" /db_xref="EnsemblGenomes-Gn:BSU23780" /db_xref="EnsemblGenomes-Tr:CAB14310" /db_xref="GOA:P54554" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11746" /db_xref="UniProtKB/Swiss-Prot:P54554" /translation="MKHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLI EIKRKITEEWSGQCEIFPLDVGRLEDIARVRDQIGSIDVLINNAGFGIFETVLDSTLD DMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVL GYSNALRMELSGTGIYVTTVNPGPIQTDFFSIADKGGDYAKNVGRWMLDPDDVAAQIT AAIFTKKREINLPRLMNAGTKLYQLFPALVEKLAGRALMKK*" /label="yqjQ CDS" gene complement(1985070..1985849) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /label="yqjQ gene" CDS complement(1985855..1986814) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390260.1" /db_xref="EnsemblGenomes-Gn:BSU23790" /db_xref="EnsemblGenomes-Tr:CAB14311" /db_xref="GOA:P54553" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11745" /db_xref="UniProtKB/Swiss-Prot:P54553" /translation="MTTEDVIAIRVPTPFAVGDVIVYLVKGDALTLIDAGPNTKEAAR ALQEQLAAVNVKLSDIEQVVLTHHHADHAGLLDVFSDEIEVIGHTFNEPYISQNQAFM DWQKRFFQKLLPELGVPFDTGKAEKLIRSAYAFSCTRSLTKSIREGMGIDGLEGWSVL EMPGHAESHIVLFHEKSGRMLGGDLLLANSSSNPILEAPKAGDVRSKPLVDYQRSLRR LSQLDPTIVFPGHGEPITSVQALIEKRFDKQRNRTEDVRRMLDEKPMTAFQVCQQLFP AVYEKELFLTMSETAGHLDVLEAEEAITSYWEGNTVYFKTMKR*" /label="yqjP CDS" gene complement(1985855..1986814) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /label="yqjP gene" promotor_-10 complement(1986836..1986855) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1986855) /Source="Nicolas_upshifts" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1986870..1986877) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1986911..1986918 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1986932..1987218 /Source="Nicolas_S_feature" /locus_tag="new_2472864_2473150" /HighExp="Diami, C90, BC, Paraq, G180, GM 15, Oxctl, S7, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S902" upshifts 1986932 /Source="Nicolas_upshifts" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1986934..1986953 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1986948..1987193 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /product="proline T-box riboswitch" /experiment="publication(s) with functional evidences, PMID:21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21233158" /label="pswI RNA" gene 1986948..1987193 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /label="pswI gene" CDS 1987219..1988055 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21233158, 28752945, 28824574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21233158, 28752945, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase (NADP-dependent, weak activity)" /protein_id="NP_390261.1" /db_xref="EnsemblGenomes-Gn:BSU23800" /db_xref="EnsemblGenomes-Tr:CAB14312" /db_xref="GOA:P54552" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11744" /db_xref="UniProtKB/Swiss-Prot:P54552" /translation="MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIE LKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIE TIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVE ERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSG KQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALER HS*" /label="proI CDS" gene 1987219..1988055 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /label="proI gene" downshifts 1988053 /Source="Nicolas_upshifts" /id="D1238" /incds=0 /nref=29 /ntot=190 /MaxReadThrough="0.55696" /MaxDrop="3.78131" /score="36.2472665" /energy="-12" /TU="NA" /idTUdmin="U1859" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1988096..1989739) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase" /protein_id="NP_390262.2" /db_xref="EnsemblGenomes-Gn:BSU23810" /db_xref="EnsemblGenomes-Tr:CAB14313" /db_xref="GOA:P54551" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG11743" /db_xref="UniProtKB/Swiss-Prot:P54551" /translation="MNWQTKDELLALLTSLVQYESITGSKGEVALAEYLYFILKDKPY FQKHPDDVTLHPMDDGRSFLTALVKKKNVKKTVLLLSHFDVVDIEDYGEFKHMACKPA ELLSSFLEKKELLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMNGHFEGNL LLITVPDEEVNSRGMIEAVPALKEMEKKHDITLTACLNAEPMFEKFPGDQQQYFYTGS IGKVLAGFFCKGIETHVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNL MQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQMLLKTAEQAAEEIMSNVRKKTQD FQQFEPFQPIERDVTVLTFDELVSRAKKRAGISETERALNYAFANRGELGDRDFSTKI VSELASLCKEDAPLIVLFYSPPLYPAVSSKDDQLIRNTADQIKHYAAERYGIALREVQ YFPGLSDLSYLQLEKQEVDAYTSNMPLFNRGYSLPSGKNQALYVPVLNVGPAGKDPHK WTERLYMPYSFEVLPDLLSFTISALLKQSESAGQLLREK*" /label="yqjN CDS" gene complement(1988096..1989739) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /label="yqjN gene" downshifts complement(1988108) /Source="Nicolas_upshifts" /id="D1239" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="2.2598" /MaxDrop="2.55609" /score="14.9380989" /energy="-12" /TU="NA" /idTUdmin="U1861" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1989757..1989763 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1989770 /Source="Nicolas_upshifts" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1989777..1989788 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(1989795..1989814) /Source="Nicolas_upshift_promotors" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1989800) /Source="Nicolas_upshifts" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1989846..1989853 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1989867..1989886 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1989869 /Source="Nicolas_upshifts" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 1989911..1990927 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /EC_number="1.6.99.1" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12660247, 15249051, 15890652, 20011599, 20461254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12660247, 15249051, 15890652, 20011599, 20461254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent flavin oxidoreductase (acting oncinnamaldehyde-related compounds)" /protein_id="NP_390263.1" /db_xref="EnsemblGenomes-Gn:BSU23820" /db_xref="EnsemblGenomes-Tr:CAB14314" /db_xref="GOA:P54550" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023663" /db_xref="PDB:1Z41" /db_xref="PDB:1Z42" /db_xref="PDB:1Z44" /db_xref="PDB:1Z48" /db_xref="SubtiList:BG11742" /db_xref="UniProtKB/Swiss-Prot:P54550" /translation="MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAH YISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQ LAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDV IEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSA SDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQA DMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQY ERGW*" /label="yqjM CDS" gene 1989911..1990927 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /label="yqjM gene" downshifts 1990914 /Source="Nicolas_upshifts" /id="D1240" /incds=0 /nref=42 /ntot=157 /MaxReadThrough="2.79686" /MaxDrop="5.04803" /score="39.119339" /energy="-12.8" /TU="U1862" /idTUdmin="U1862" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 1990976..1990985 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1990998..1991013 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1991002 /Source="Nicolas_upshifts" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 1991037..1991798 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390264.1" /db_xref="EnsemblGenomes-Gn:BSU23830" /db_xref="EnsemblGenomes-Tr:CAB14315" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11741" /db_xref="UniProtKB/Swiss-Prot:P54549" /translation="MKSAWMEKTYTIDGCAFHTQHRKGSSGVTIVFEAGYGTSSETWK PLMADIDDEFGIFTYDRAGIGKSGQSRAKRTADQQVKELESLLKAADVKPPYLAVSHS YGAVITGLWACKNKHDIIGMVLLDPALGDCASFTFIPEEMHKSHTRKMMLEGTHAEFS KSLQELKKRQVHLGNMPLLVLSSGERTEKFAAEQEWQNLHSSILSLSNQSGWIQAKNS SHNIHHDEPHIVHLAIYDVWCAACQQAAPLYQAVN*" /label="yqjL CDS" gene 1991037..1991798 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /label="yqjL gene" downshifts 1991706 /Source="Nicolas_upshifts" /id="D1241" /incds=1 /nref=21 /ntot=204 /MaxReadThrough="3.34804" /MaxDrop="3.21955" /score="0.451826768" /energy="-11.2" /TU="U1863" /idTUdmin="U1862" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 1991794 /Source="Nicolas_upshifts" /id="D1242" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="1.34151" /MaxDrop="3.85711" /score="0.451826768" /energy="-11.2" /TU="NA" /idTUdmin="U1863" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1991826..1992026) /Source="Nicolas_S_feature" /locus_tag="new_2477758_2477958_c" /HighExp="B60, S5, Etha, S4, B36, BMM, Heat, S3, S2, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.21631400000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S903" CDS complement(1991842..1991967) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33* pseudogene" /translation="CTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK*" /label="rpmGCc CDS" gene complement(1991842..1991967) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /pseudo /label="rpmGCc gene" downshifts complement(1991869) /Source="Nicolas_upshifts" /id="D1243" /incds=0 /nref=187 /ntot=264 /MaxReadThrough="3.91531" /MaxDrop="7.65732" /score="5.23287853" /energy="-8.8" /TU="U1864" /idTUdmin="U1865" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1991960..1991992) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 19648245, 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33C pseudogene" /db_xref="PSEUDO:CCQ48601.1" /translation="MRVNVTLALH*" /label="rpmGCn CDS" gene complement(1991960..1991992) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /pseudo /label="rpmGCn gene" promotor_-10 complement(1992020..1992039) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1992026) /Source="Nicolas_upshifts" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1992052..1992059) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1992074..1992997) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /EC_number="3.1.26.11" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 12941704, 16336119, 17005971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12941704, 16336119, 17005971; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease Z" /protein_id="NP_390265.1" /db_xref="EnsemblGenomes-Gn:BSU23840" /db_xref="EnsemblGenomes-Tr:CAB14316" /db_xref="GOA:P54548" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR013471" /db_xref="InterPro:IPR036866" /db_xref="PDB:1Y44" /db_xref="PDB:2FK6" /db_xref="PDB:4GCW" /db_xref="SubtiList:BG11740" /db_xref="UniProtKB/Swiss-Prot:P54548" /translation="MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQH QILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIET SLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKA DVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKL KELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQG DASLELQKEAVDVFPNSVAAYDFLEVNVPRG*" /label="rnz CDS" gene complement(1992074..1992997) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /label="rnz gene" promotor_-10 complement(1993023..1993042) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1993036) /Source="Nicolas_upshifts" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1993056..1993061) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1993135..1993142 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1993156..1993175 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1993158..1993223 /Source="Nicolas_S_feature" /locus_tag="new_2479090_2479155" /HighExp="dia5, C90, MG 5, Lbexp, MG t5, MG 45, M9-exp, GM 90, GM 120, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S904" upshifts 1993158 /Source="Nicolas_upshifts" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="upshifts" CDS 1993224..1994693 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /EC_number="1.1.1.49" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1704005, 19779711, 26129872" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1704005, 19779711, 26129872; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate 1-dehydrogenase (NADP-dependent)" /protein_id="NP_390266.2" /db_xref="EnsemblGenomes-Gn:BSU23850" /db_xref="EnsemblGenomes-Tr:CAB14317" /db_xref="GOA:P54547" /db_xref="InterPro:IPR001282" /db_xref="InterPro:IPR019796" /db_xref="InterPro:IPR022674" /db_xref="InterPro:IPR022675" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11739" /db_xref="UniProtKB/Swiss-Prot:P54547" /translation="MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAV VGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQ LEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSES LGVEDRARYYEKSGALRDMVQNHIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPI AKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVP FYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKK LGGAAHAQPIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDS ISETWAANKTLSPNYESGSMGPKESDDLLVKDGLHWWNI*" /label="zwf CDS" gene 1993224..1994693 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /label="zwf gene" downshifts 1994676 /Source="Nicolas_upshifts" /id="D1244" /incds=0 /nref=206 /ntot=286 /MaxReadThrough="3.46838" /MaxDrop="7.76173" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" terminator 1994701..1994740 /created_by="User" /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" /label="Delta6_zwf-T-gndA_Terminator" Polymorphism join(1994713,1994716) /Source="geneious" /ID="SNP_BsDelta6_2480646_2480647" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="TA -> AT" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TA" /Variant_Nucleotides="AT" /Variant_P_Value=0 /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(1994721,1994722) /Source="geneious" /ID="SNP_BsDelta6_2480654_2480654" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.1e-279" /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(1994733,1994734) /Source="geneious" /ID="SNP_BsDelta6_2480667_2480667" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=116 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.9e-244" /Variant_Raw_Frequency=110 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 1994742 /Source="Nicolas_upshifts" /id="D1245" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="2.5392" /MaxDrop="4.74183" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1994816..1996225) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /EC_number="1.1.1.44" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 15755726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 15755726; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP+-dependent 6-P-gluconate dehydrogenase" /protein_id="NP_390267.2" /db_xref="EnsemblGenomes-Gn:BSU23860" /db_xref="EnsemblGenomes-Tr:CAB14318" /db_xref="GOA:P80859" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11738" /db_xref="UniProtKB/Swiss-Prot:P80859" /translation="MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQ EAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGN TYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVF AEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVP LPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSY AQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDS YFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFG AHTYERTDKEGIFHTEWMK*" /label="gndA CDS" gene complement(1994816..1996225) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /label="gndA gene" downshifts complement(1994833) /Source="Nicolas_upshifts" /id="D1246" /incds=0 /nref=220 /ntot=361 /MaxReadThrough="1.88983" /MaxDrop="8.82894" /score="24.3727084" /energy="-18" /TU="NA" /idTUdmin="U1867" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" downshifts complement(1994906) /Source="Nicolas_upshifts" /id="D1247" /incds=1 /nref=1 /ntot=36 /MaxReadThrough="8.40595" /MaxDrop="2.3555" /score="24.3727084" /energy="-18" /TU="U1867" /idTUdmin="U1867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" misc_feature complement(1996289..1996307) /Source="Nicolas_upshift_promotors" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1996291) /Source="Nicolas_upshifts" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1996335..1997579) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /EC_number="2.7.7.7" /function="16.6: Maintain" /function="16.5: Explore" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-damage lesion bypass DNA polymerase" /protein_id="NP_390268.2" /db_xref="EnsemblGenomes-Gn:BSU23870" /db_xref="EnsemblGenomes-Tr:CAB14319" /db_xref="GOA:P54545" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017061" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11737" /db_xref="UniProtKB/Swiss-Prot:P54545" /translation="MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKG IVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLV EPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMK KPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRL LGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASV SDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNP VRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLK KEESKTKGTSFNKDFFQDEKKS*" /label="polYA CDS" gene complement(1996335..1997579) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /label="polYA gene" S_feature complement(1997580..1997854) /Source="Nicolas_S_feature" /locus_tag="new_2483514_2483788_c" /HighExp="M40t90, Sw, M40t45, H2O2, C30, Cold, Etha, C90, Diami, BC" /AntisenseName="yqzJ" /AntisenseCor="0.48883700687558601" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S905" promotor_-35 1997600..1997607 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1997621..1997640 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1997621 /Source="Nicolas_upshifts" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="upshifts" CDS 1997652..1997939 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /experiment="publication(s) with functional evidences, PMID:19779460, 21383133, 22720735, 25313395, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19779460, 21383133, 22720735, 25313395, 25903689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of OxaAB translation" /protein_id="YP_054586.1" /db_xref="EnsemblGenomes-Gn:BSU23880" /db_xref="EnsemblGenomes-Tr:CAE01460" /db_xref="GOA:Q7WY64" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG14191" /db_xref="UniProtKB/Swiss-Prot:Q7WY64" /translation="MTMFVESINDVLFLVDFFTIILPALTAIGIAFLLRECRAGEQWK SKRTDEHQTVFHINRTDFLIIIYHRITTWIRKVFRMNSPVNDEEDAGSLLL*" /label="mifM CDS" gene 1997652..1997939 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /label="mifM gene" promotor_-10 complement(1997836..1997855) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-10" upshifts complement(1997856) /Source="Nicolas_upshifts" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="upshifts" promotor_-35 complement(1997871..1997874) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-35" CDS 1997970..1998797 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_390269.1" /db_xref="EnsemblGenomes-Gn:BSU23890" /db_xref="EnsemblGenomes-Tr:CAB14320" /db_xref="GOA:P54544" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG11736" /db_xref="UniProtKB/Swiss-Prot:P54544" /translation="MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYL IEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQ VDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIR STPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAK LMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK* " /label="oxaAB CDS" gene 1997970..1998797 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /label="oxaAB gene" downshifts 1998614 /Source="Nicolas_upshifts" /id="D1248" /incds=1 /nref=4 /ntot=125 /MaxReadThrough="5.05074" /MaxDrop="3.49092" /score="-5.67811369" /energy="-7.6" /TU="U1868" /idTUdmin="U1868" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 1998790 /Source="Nicolas_upshifts" /id="D1249" /incds=0 /nref=71 /ntot=229 /MaxReadThrough="1.09826" /MaxDrop="6.56698" /score="-5.67811369" /energy="-7.6" /TU="NA" /idTUdmin="U1868" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1998802..1999722) /Source="Nicolas_S_feature" /locus_tag="new_2484736_2485656_c" /HighExp="LoTm, B36, M0t90, M40t90, Lbstat, M9-stat, T1.30H, B60, LBGtran, BT" /AntisenseName="yqjF" /AntisenseCor="0.18628881890353799" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S906" downshifts complement(1998845) /Source="Nicolas_upshifts" /id="D1250" /incds=0 /nref=170 /ntot=248 /MaxReadThrough="0.24428" /MaxDrop="6.31082" /score="18.1943524" /energy="-12.4" /TU="NA" /idTUdmin="U1871" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1998915..1998921 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1998935..1998953 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1998944 /Source="Nicolas_upshifts" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="upshifts" CDS 1998977..1999705 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390270.3" /db_xref="EnsemblGenomes-Gn:BSU23900" /db_xref="EnsemblGenomes-Tr:CAB14321" /db_xref="InterPro:IPR018644" /db_xref="InterPro:IPR023375" /db_xref="SubtiList:BG11735" /db_xref="UniProtKB/Swiss-Prot:P54543" /translation="MTERFQQKNISVPDGIWIMRQTWNDVLFAHWPVDVSILRALVPS VLELDTYNGQAWISMLPFMLTNLRARYLPVIPGARAFPELNLRTYVTYKGKPGIYFFS LDADHRLAVLGARTFFHLPYFYADMKSEKNGDAIDYVSKRKNDKEAAFHAAYRPISAP FTAEKDSLDYWLTERYRLYTTYRNKLYYEDIHHHPWLLQNAEAEISVNTVTDAHGITL PESDPLLHYAKKQDVLFWPLRKWS*" /label="yqjF CDS" gene 1998977..1999705 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /label="yqjF gene" CDS complement(1999746..2000861) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase or deacylase" /protein_id="NP_390271.2" /db_xref="EnsemblGenomes-Gn:BSU23910" /db_xref="EnsemblGenomes-Tr:CAB14322" /db_xref="GOA:P54542" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR010162" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11734" /db_xref="UniProtKB/Swiss-Prot:P54542" /translation="MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKE DDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTI LGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGY ALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRI DEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGG RAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTV NLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK*" /label="yqjE CDS" gene complement(1999746..2000861) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /label="yqjE gene" downshifts complement(1999767) /Source="Nicolas_upshifts" /id="D1251" /incds=0 /nref=23 /ntot=203 /MaxReadThrough="3.90071" /MaxDrop="3.95711" /score="11.6635037" /energy="-10.6" /TU="U1871" /idTUdmin="U1871" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" CDS complement(2000879..2002402) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /EC_number="6.4.1.3" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative propionyl-CoA carboxylase beta chain" /protein_id="NP_390272.2" /db_xref="EnsemblGenomes-Gn:BSU23920" /db_xref="EnsemblGenomes-Tr:CAB14323" /db_xref="GOA:P54541" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG11733" /db_xref="UniProtKB/Swiss-Prot:P54541" /translation="MNEHMDHFYTKRKQAEEGGGREKLAQQRQKGKLTARERIIFLLD QDSFIELHPFMESQVLTREQRMLGDGVVTGYGTIDGRSVYVFAQDFTVYGGALGETHA RKICALMDLAAKNKAPIIGLNDSGGARIQEGVLSLDGYGHIFYRNVLYSGVIPQISVI LGPCAGGAVYSPALTDFIFMAEQTGRMFITGPKVIEKVTGEQVDAESLGGAGIHNAVS GNAHFSGHTEKEVLTGVRKLLSYLPLNGRTTEPKPEKEASRPLLNRLVPADTTKPYDV RKVIRELADPQSFFEIQPFFAKNIVIGFARLGEKAIGIVASQPKHLAGSLTIDAADKA ARFIRFCDAFDIPLLTVEDVPGFLPGIQQEHNGIIRHGAKLLFAYAEATVPKVTLIIR KAYGGAYVAMNSKAIGADLVFAWPNAEIAVMGPEGAASILYEKEIKASADPQKTKREK TAEYKKQNAGPYKAAACGMVDDIILPEESRGRLIQAFHMLTHKTEERPKKKHGNIPL* " /label="yqjD CDS" gene complement(2000879..2002402) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /label="yqjD gene" promotor_-10 complement(2001985..2002004) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2002007) /Source="Nicolas_upshifts" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2002019..2002023) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2002395..2002817) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /EC_number="5.1.99.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methylmalonyl-CoA epimerase" /protein_id="NP_390273.2" /db_xref="EnsemblGenomes-Gn:BSU23930" /db_xref="EnsemblGenomes-Tr:CAB14324" /db_xref="GOA:P54540" /db_xref="InterPro:IPR017515" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11732" /db_xref="UniProtKB/Swiss-Prot:P54540" /translation="MNRLDHIGIAVFSIKDARSFYENVLGLAFLHQETVEEQKVNVAF FQAGSVKLELIEPLTADSPVHLFLEKKGQGLHHIAFLCNCLSEQLQALSDQHVQLIDR FPRQGANGKKIAFISPRETNGVLVELCEPKGDQHNEHE*" /label="yqjC CDS" gene complement(2002395..2002817) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /label="yqjC gene" promotor_-35 2002846..2002853 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2002867..2002886 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2002881..2003034 /Source="Nicolas_S_feature" /locus_tag="new_2488815_2488968" /HighExp="LPhT, Etha, dia15, Salt, M9-stat, LBGstat, Heat, BC, T-0.40H, HiOs" /AntisenseName="yqjB" /AntisenseCor="-0.57221813594264503" /AntisenseRegPval="-24.1" /CDS_PredictionProba="0.99822200000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S907" upshifts 2002881 /Source="Nicolas_upshifts" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="upshifts" downshifts 2002991 /Source="Nicolas_upshifts" /id="D1252" /incds=0 /nref=1 /ntot=140 /MaxReadThrough="3.88708" /MaxDrop="3.25163" /score="3.10927996" /energy="-7" /TU="U1872" /idTUdmin="U1872" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" CDS complement(2003019..2003549) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /EC_number="2.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative L,D-transpeptidase" /protein_id="NP_390274.1" /db_xref="EnsemblGenomes-Gn:BSU23940" /db_xref="EnsemblGenomes-Tr:CAB14325" /db_xref="GOA:P54539" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG11731" /db_xref="UniProtKB/Swiss-Prot:P54539" /translation="MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDN KVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKG TDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEI AIEHKALIKKQDIPIE*" /label="yqjB CDS" gene complement(2003019..2003549) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /label="yqjB gene" S_feature 2003036..2003671 /Source="Nicolas_S_feature" /locus_tag="new_2488970_2489605" /HighExp="LPhT, H2O2, BC, Salt, dia15, M9-stat, Heat, LBGstat, T5.0H, Etha" /AntisenseName="yqjB" /AntisenseCor="-0.31126010332536502" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S908" promotor_-10 complement(2003566..2003577) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2003573) /Source="Nicolas_upshifts" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2003592..2003598) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2003601..2004569) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390275.2" /db_xref="EnsemblGenomes-Gn:BSU23950" /db_xref="EnsemblGenomes-Tr:CAB14326" /db_xref="GOA:P54538" /db_xref="InterPro:IPR010343" /db_xref="InterPro:IPR021062" /db_xref="SubtiList:BG11730" /db_xref="UniProtKB/Swiss-Prot:P54538" /translation="MFKIGYRTIKTALGTALAIYISQLLHLQNFASAGIITILCIQIT QKRSLQASWARFSACCLAIAFSYLFFELIGYHPFVIGALLLIFIPITVLLKINEGIVT SSVIILHLYMSGGITPTFIWNEVQLITVGIGVALLMNLYMPSLDRKLIAYRKKIEDNF AVIFAEIERYLLTGEQDWSGKEIPETHQLITEAKNLAYRDVQNHILRYENLHYHYFKM REKQFEIIERLLPKVTSISITVDQGKMIAEFIHDLREAIHPGNTAYKFLKRLADMRKE FEEMPLPATREEFEARAALFHLLGEMEQYLVIKSYFKGIKAQKSLG*" /label="yqjA CDS" gene complement(2003601..2004569) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /label="yqjA gene" downshifts complement(2003617) /Source="Nicolas_upshifts" /id="D1253" /incds=0 /nref=79 /ntot=223 /MaxReadThrough="2.22356" /MaxDrop="3.94894" /score="1.98299685" /energy="-14.1" /TU="NA" /idTUdmin="U1874" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2004640..2005362) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (ATP-binding protein)" /protein_id="NP_390276.1" /db_xref="EnsemblGenomes-Gn:BSU23960" /db_xref="EnsemblGenomes-Tr:CAB14327" /db_xref="GOA:P54537" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11729" /db_xref="UniProtKB/Swiss-Prot:P54537" /translation="MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFL RCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAP VNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLF DEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDG NPKEFFMSPKSKRAQDFLEKIL*" /label="artR CDS" gene complement(2004640..2005362) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /label="artR gene" downshifts complement(2004651) /Source="Nicolas_upshifts" /id="D1254" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="4.81216" /MaxDrop="4.0342" /score="0.346345754" /energy="-7" /TU="U1874" /idTUdmin="U1874" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS complement(2005355..2006014) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (permease)" /protein_id="NP_390277.1" /db_xref="EnsemblGenomes-Gn:BSU23970" /db_xref="EnsemblGenomes-Tr:CAB14328" /db_xref="GOA:P54536" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11728" /db_xref="UniProtKB/Swiss-Prot:P54536" /translation="MNLDFSATIPQIPFILEGLAITLKIVVVSAIIGLILGIVLSLCK ISTFRPFIWIADFYTSVFRGTPLVLQLMIVYFGLPQLLGFQIDQFWAAVVALSLNSAA YVSEIIRAGINAIDKGQKEAAVALGVPYGKMMKDLLLPQAFKNISPAIVNELITLTKE SAIVTVIGLGDVMRRAYQAGAATYNYLEPLIIAGLIYYVLVLILTFIGKAVERKLKSN D*" /label="artQ CDS" gene complement(2005355..2006014) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /label="artQ gene" S_feature complement(2006015..2006094) /Source="Nicolas_S_feature" /locus_tag="new_2491949_2492028_c" /HighExp="S1, S2, ferm, MG 15, Fru, Glu, BMM, S3, UNK1, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S909" CDS complement(2006095..2006862) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter binding lipoprotein" /protein_id="NP_390278.1" /db_xref="EnsemblGenomes-Gn:BSU23980" /db_xref="EnsemblGenomes-Tr:CAB14329" /db_xref="GOA:P54535" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11727" /db_xref="UniProtKB/Swiss-Prot:P54535" /translation="MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKP FEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTP ERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYG FKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAI AFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK*" /label="artP CDS" gene complement(2006095..2006862) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /label="artP gene" promotor_-10 complement(2006912..2006931) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2006927) /Source="Nicolas_upshifts" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2006946..2006953) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2007130..2007567) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /experiment="publication(s) with functional evidences, PMID:21749987, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21749987, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin B (de-bacillithiolation)" /protein_id="NP_390279.1" /db_xref="EnsemblGenomes-Gn:BSU23990" /db_xref="EnsemblGenomes-Tr:CAB14330" /db_xref="InterPro:IPR009474" /db_xref="SubtiList:BG11726" /db_xref="UniProtKB/Swiss-Prot:P54534" /translation="MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTT LVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSS PSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV*" /label="brxB CDS" gene complement(2007130..2007567) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /label="brxB gene" downshifts complement(2007139) /Source="Nicolas_upshifts" /id="D1255" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="3.9242" /MaxDrop="7.06654" /score="21.489397" /energy="-11.8" /TU="U1875" /idTUdmin="U1875" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2007591..2007610) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-10" upshifts complement(2007612) /Source="Nicolas_upshifts" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="upshifts" promotor_-35 complement(2007625..2007632) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-35" promotor_-35 2007665..2007671 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2007684 /Source="Nicolas_upshifts" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2007686..2007704 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2007728..2008621 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /EC_number="2.7.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7961792, 8098708, 10220166, 17114254, 17535816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipid kinase BmrU" /protein_id="NP_390280.2" /db_xref="EnsemblGenomes-Gn:BSU24000" /db_xref="EnsemblGenomes-Tr:CAB14331" /db_xref="GOA:P39074" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG10302" /db_xref="UniProtKB/Swiss-Prot:P39074" /translation="MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKK KDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVL GIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKI SYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGL LDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYT HTPAVIQVLPQHIDMLVPANE*" /label="bmrU CDS" gene 2007728..2008621 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /label="bmrU gene" promotor_-35 2008654..2008661 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2008677..2008696 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2008685 /Source="Nicolas_upshifts" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" CDS 2008722..2009891 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10200972, 10961951, 11321573, 15849754, 16850406, 25756668" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_390281.2" /db_xref="EnsemblGenomes-Gn:BSU24010" /db_xref="EnsemblGenomes-Tr:CAB14332" /db_xref="GOA:P33449" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10303" /db_xref="UniProtKB/Swiss-Prot:P33449" /translation="MEKKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVG YMVACFAITQLIVSPIAGRWVDRFGRKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRM LGGISAAFIMPGVTAFIADITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRL PFFFAAAFALLAAILSILTLREPERNPENQEIKGQKTGFKRIFAPMYFIAFLIILISS FGLASFESLFALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIR YSLILSTSLVFLLTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSKIAGNEQGFAGGM NSMFTSIGNVFGPIIGGMLFDIDVNYPFYFATVTLAIGIALTIAWKAPAHLKAST*" /label="bmr CDS" gene 2008722..2009891 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /label="bmr gene" downshifts 2009874 /Source="Nicolas_upshifts" /id="D1256" /incds=0 /nref=6 /ntot=31 /MaxReadThrough="4.82186" /MaxDrop="5.02667" /score="-1.94257488" /energy="-18" /TU="U1876,U1877" /idTUdmin="U1876" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" CDS 2009964..2010800 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11201751, 11839496, 12682015, 14985361, 18658145, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family)" /protein_id="NP_390282.2" /db_xref="EnsemblGenomes-Gn:BSU24020" /db_xref="EnsemblGenomes-Tr:CAB14333" /db_xref="GOA:P39075" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="PDB:1BOW" /db_xref="PDB:1EXI" /db_xref="PDB:1EXJ" /db_xref="PDB:1R8E" /db_xref="PDB:2BOW" /db_xref="PDB:3D6Y" /db_xref="PDB:3D6Z" /db_xref="PDB:3D70" /db_xref="PDB:3D71" /db_xref="PDB:3IAO" /db_xref="PDB:3Q1M" /db_xref="PDB:3Q2Y" /db_xref="PDB:3Q3D" /db_xref="PDB:3Q5P" /db_xref="PDB:3Q5R" /db_xref="PDB:3Q5S" /db_xref="SubtiList:BG10304" /db_xref="UniProtKB/Swiss-Prot:P39075" /translation="MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRY YTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE QTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIE SADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYA CIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRI AE*" /label="bmrR CDS" gene 2009964..2010800 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /label="bmrR gene" downshifts 2010798 /Source="Nicolas_upshifts" /id="D1257" /incds=0 /nref=5 /ntot=156 /MaxReadThrough="4.1979" /MaxDrop="4.72542" /score="5.00815505" /energy="-15.7" /TU="NA" /idTUdmin="U1876" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2010862) /Source="Nicolas_upshifts" /id="D1258" /incds=0 /nref=15 /ntot=247 /MaxReadThrough="3.01431" /MaxDrop="6.04069" /score="8.5296919" /energy="-16.8" /TU="U1879" /idTUdmin="U1878" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2010862..2012136) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /EC_number="2.3.1.168" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)" /protein_id="NP_390283.1" /db_xref="EnsemblGenomes-Gn:BSU24030" /db_xref="EnsemblGenomes-Tr:CAB14334" /db_xref="GOA:P37942" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10305" /db_xref="UniProtKB/Swiss-Prot:P37942" /translation="MAIEQMTMPQLGESVTEGTISKWLVAPGDKVNKYDPIAEVMTDK VNAEVPSSFTGTITELVGEEGQTLQVGEMICKIETEGANPAEQKQEQPAASEAAENPV AKSAGAADQPNKKRYSPAVLRLAGEHGIDLDQVTGTGAGGRITRKDIQRLIETGGVQE QNPEELKTAAPAPKSASKPEPKEETSYPASAAGDKEIPVTGVRKAIASNMKRSKTEIP HAWTMMEVDVTNMVAYRNSIKDSFKKTEGFNLTFFAFFVKAVAQALKEFPQMNSMWAG DKIIQKKDINISIAVATEDSLFVPVIKNADEKTIKGIAKDITGLAKKVRDGKLTADDM QGGTFTVNNTGSFGSVQSMGIINYPQAAILQVESIVKRPVVMDNGMIAVRDMVNLCLS LDHRVLDGLVCGRFLGRVKQILESIDEKTSVY*" /label="bkdB CDS" gene complement(2010862..2012136) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /label="bkdB gene" CDS complement(2012159..2013142) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /EC_number="1.2.4.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390284.1" /db_xref="EnsemblGenomes-Gn:BSU24040" /db_xref="EnsemblGenomes-Tr:CAB14335" /db_xref="GOA:P37941" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10306" /db_xref="UniProtKB/Swiss-Prot:P37941" /translation="MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGL YEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIR YRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKA AVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFAL QAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAI ISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF*" /label="bkdAB CDS" gene complement(2012159..2013142) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /label="bkdAB gene" CDS complement(2013156..2014148) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /EC_number="1.2.4.4" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390285.1" /db_xref="EnsemblGenomes-Gn:BSU24050" /db_xref="EnsemblGenomes-Tr:CAB14336" /db_xref="GOA:P37940" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR034616" /db_xref="SubtiList:BG10307" /db_xref="UniProtKB/Swiss-Prot:P37940" /translation="MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPF VISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS GGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQG DFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGND PLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPL LTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK*" /label="bkdAA CDS" gene complement(2013156..2014148) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /label="bkdAA gene" CDS complement(2014170..2015594) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /EC_number="1.8.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase)" /protein_id="NP_390286.2" /db_xref="EnsemblGenomes-Gn:BSU24060" /db_xref="EnsemblGenomes-Tr:CAB14337" /db_xref="GOA:P54533" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11725" /db_xref="UniProtKB/Swiss-Prot:P54533" /translation="MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLH KGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLM KKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPG LEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILP TEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKML VSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHE GIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAI GKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTI HPHPTLSEAIGEAALAADGKAIHF*" /label="lpdV CDS" gene complement(2014170..2015594) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /label="lpdV gene" CDS complement(2015615..2016706) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /EC_number="2.7.2.-" /EC_number="2.7.2.7" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain fatty-acid kinase" /protein_id="NP_390287.2" /db_xref="EnsemblGenomes-Gn:BSU24070" /db_xref="EnsemblGenomes-Tr:CAB14338" /db_xref="GOA:P54532" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR011245" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG11724" /db_xref="UniProtKB/Swiss-Prot:P54532" /translation="MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQ RFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDL KSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFH ALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSP ERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKA RFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVY PGENELQSLAQGALRVLQGEEQSKQYRIE*" /label="buk CDS" gene complement(2015615..2016706) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /label="buk gene" CDS complement(2016725..2017819) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /EC_number="1.4.1.8" /EC_number="1.4.1.-" /EC_number="1.4.1.9" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid dehydrogenase" /protein_id="NP_390288.1" /db_xref="EnsemblGenomes-Gn:BSU24080" /db_xref="EnsemblGenomes-Tr:CAB14339" /db_xref="GOA:P54531" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR016211" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11723" /db_xref="UniProtKB/Swiss-Prot:P54531" /translation="MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTR MWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRY IQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKA AAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGA RAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEM GIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLA ADRLAEERIERMRRSRSQFLQNGHSVLSRR*" /label="bcd CDS" gene complement(2016725..2017819) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /label="bcd gene" CDS complement(2017831..2018730) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /EC_number="2.3.1.19" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphate BCFA and butyryl coenzyme A transferase" /protein_id="NP_390289.2" /db_xref="EnsemblGenomes-Gn:BSU24090" /db_xref="EnsemblGenomes-Tr:CAB14340" /db_xref="GOA:P54530" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR012147" /db_xref="InterPro:IPR014079" /db_xref="SubtiList:BG11722" /db_xref="UniProtKB/Swiss-Prot:P54530" /translation="MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFL LTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLL KAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVA HAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQ IAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSR ADSAENKLYSIALAICASEEYTH*" /label="ptb CDS" gene complement(2017831..2018730) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /label="ptb gene" misc_feature complement(2018766..2018785) /Source="Nicolas_upshift_promotors" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2018771) /Source="Nicolas_upshifts" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2018773..2018854) /Source="Nicolas_S_feature" /locus_tag="new_2504707_2504788_c" /HighExp="Cold, LBGtran, G180, Lbexp, G135, G150, LBGexp, Diami, Oxctl, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S910" CDS complement(2018855..2020933) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_390290.1" /db_xref="EnsemblGenomes-Gn:BSU24100" /db_xref="EnsemblGenomes-Tr:CAB14341" /db_xref="GOA:P54529" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11721" /db_xref="UniProtKB/Swiss-Prot:P54529" /translation="MQKVLIVGAGKRGTALLHILIKTAIIDIIAVVDKDPEAPGLKEA EQYGIAVSSDWKPYIQQKPDIVIHTTGDQAVFDELLQRKHEDTIVMPGKMAYIVFQLM EEKQHLIQMLKEQTYKYDRIFNSTHDGMIFIDINEEIILFNHMAEKMVGKKREEVIGR PIKEVIPSTKMPRILKTRVPEYNQKQLLGDHLQIVTTRLPIIDEGGRLLGALCVFKDI TDAVELAEEVTNLKQVRTMLEAIIQSSDEAISVVDENGIGLLINKAYTKMTGLSEKEV IGKPANTDISEGESMHLKVLETRRPVRGVRMKVGPNEKEVIVNVAPVIVDGILKGSVG VIHDVSEIKMLTAELNRARQIIRTLEAKYTFDDIIGKSEQMLVALEQAKLGAKTPATI LLRGESGTGKELFAHAIHNESDRKYNKFIRVNCAALSENLLESELFGYEDGAFSGAKR GGKKGLFEEANNGSIFLDEIGELTQNMQAKLLRVLQEKEIVRVGGTKAIPVNVRVIAA TNVNIEKAMADGTFREDLYYRINRYPISIPPLRQRLEDIEALSVRLIQKINRDYGRNV KGLSQQALRALSAYHWPGNVRELENVLGRAMIFLNPHMEWIEKDHLPVFELEQKENDT DQGTGFDFPDIEGEKLSVAVEKFEAHLIQQTLEKHHFNRTKTAKALGVSIRNLYYKMD KYGLANEGMQ*" /label="bkdR CDS" gene complement(2018855..2020933) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /label="bkdR gene" promotor_-10 complement(2020993..2021012) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2021010) /Source="Nicolas_upshifts" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2021020..2021027 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2021029..2021032) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2021041..2021060 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2021048 /Source="Nicolas_upshifts" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="upshifts" CDS 2021086..2021322 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390291.1" /db_xref="EnsemblGenomes-Gn:BSU24110" /db_xref="EnsemblGenomes-Tr:CAB14342" /db_xref="GOA:O32015" /db_xref="InterPro:IPR020138" /db_xref="SubtiList:BG13772" /db_xref="UniProtKB/Swiss-Prot:O32015" /translation="MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGL SGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR*" /label="yqzF CDS" gene 2021086..2021322 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /label="yqzF gene" downshifts 2021313 /Source="Nicolas_upshifts" /id="D1259" /incds=0 /nref=64 /ntot=230 /MaxReadThrough="2.80342" /MaxDrop="5.10794" /score="42.7247617" /energy="-11.9" /TU="NA" /idTUdmin="U1880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2021364..2022269) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /EC_number="4.1.3.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12706720, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12706720, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylisocitrate lyase" /protein_id="NP_390292.1" /db_xref="EnsemblGenomes-Gn:BSU24120" /db_xref="EnsemblGenomes-Tr:CAB14343" /db_xref="GOA:P54528" /db_xref="InterPro:IPR012695" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018523" /db_xref="SubtiList:BG11720" /db_xref="UniProtKB/Swiss-Prot:P54528" /translation="MSWIVNKQSSQEELAGRFRKLMSAPDILQIPGAHDGMAALLAKE AGFSAIYLSGAAYTASRGLPDLGIITSAEIAERAKDLVRAADLPLLVDIDTGFGGVLN AARTAREMLEARVAAVQMEDQQLPKKCGHLNGKQLVPIKEMAQKIKAIKQAAPSLIVV ARTDARAQEGLDAAIKRSEAYIEAGADAIFPEALQAENEFRQFAERIPVPLLANMTEF GKTPYYRADEFEDMGFHMVIYPVTSLRAAAKACERMFGLMKEHGSQKEGLHDMQTRKE LYDTISYYDYEALDKTIAKTVLPDE*" /label="mmgF CDS" gene complement(2021364..2022269) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /label="mmgF gene" downshifts complement(2021367) /Source="Nicolas_upshifts" /id="D1260" /incds=0 /nref=29 /ntot=69 /MaxReadThrough="2.12559" /MaxDrop="5.62" /score="33.814061" /energy="-11.9" /TU="NA" /idTUdmin="U1884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2022287..2023705) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /EC_number="4.2.1.79" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylcitrate dehydratase (promiscuous)" /protein_id="NP_390293.2" /db_xref="EnsemblGenomes-Gn:BSU24130" /db_xref="EnsemblGenomes-Tr:CAB14344" /db_xref="GOA:P45859" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR012705" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11323" /db_xref="UniProtKB/Swiss-Prot:P45859" /translation="MPKTDRVIEEITDYVLEKEITSAEAYTTAGHVLLDTLGCGILAL RYPECTKLLGPIVPGTTVPNGSKVPGTSYVLDPVRAAFNIGCMIRWLDYNDTWLAAEW GHPSDNLGGILAAADYVSRVRLSEGKEPLTVRDVLEMMIKAHEIQGVLALENSLNRVG LDHVLFVKVATTAVAAKLLGGGREEIKNALSNAWIDNAALRTYRHSPNTGSRKSWAAG DATSRGVHLALMSLKGEMGYPTALSAPGWGFQDVLFNKKEIKLARPLDAYVMENVLFK VSYPAEFHAQTAAESAVILHPQVKNRIDEIDRVVIRTHESAIRIIDKKGPLHNPADRD HCLQYITAIGLLFGDITAQHYEAETANDPRIDKLRDKMEVTENKTYTEDYLKPDKRSI SNAVQVHFKDGTSTEMVECEFPLGHRFRREEAVPKLLEKFSDNLKTHFPDKQHKHIYE RCTSYETLQTMRVNEFVDMFCM*" /label="mmgE CDS" gene complement(2022287..2023705) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /label="mmgE gene" misc_feature complement(2022582..2022601) /Source="Nicolas_upshift_promotors" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2022599) /Source="Nicolas_upshifts" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2023720..2024838) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /EC_number="2.3.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional citrate synthase/2-methylcitrate synthase" /protein_id="NP_390294.1" /db_xref="EnsemblGenomes-Gn:BSU24140" /db_xref="EnsemblGenomes-Tr:CAB14345" /db_xref="GOA:P45858" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG11322" /db_xref="UniProtKB/Swiss-Prot:P45858" /translation="MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSET KSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTG LSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSAN FLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASL KGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMM KEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPI FFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS*" /label="mmgD CDS" gene complement(2023720..2024838) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /label="mmgD gene" CDS complement(2024872..2026011) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="propionyl-CoA dehydrogenase subunit" /protein_id="NP_390295.2" /db_xref="EnsemblGenomes-Gn:BSU24150" /db_xref="EnsemblGenomes-Tr:CAB14346" /db_xref="GOA:P45857" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="PDB:5LNX" /db_xref="SubtiList:BG11321" /db_xref="UniProtKB/Swiss-Prot:P45857" /translation="MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMG KHGLMGIPVPEQYGGAGADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNE EQKMKYIPNLASGDHLGAFALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGA ADIYITFALTAPDQGRHGISAFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVP EANLLGKEGDGFHIAMANLNVGRIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAAN QGISFKLADMATRAEAARHLVYHAADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQ IYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQRLIISKYLLGGT*" /label="mmgC CDS" gene complement(2024872..2026011) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /label="mmgC gene" CDS complement(2026039..2026902) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /EC_number="1.1.1.157" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 18461320, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 18461320, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxybutyryl-CoA dehydrogenase" /protein_id="NP_390296.2" /db_xref="EnsemblGenomes-Gn:BSU24160" /db_xref="EnsemblGenomes-Tr:CAB14347" /db_xref="GOA:P45856" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR006180" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR022694" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11320" /db_xref="UniProtKB/Swiss-Prot:P45856" /translation="MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLK RLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFK TLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATS EETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSG RGFYDYEEKTS*" /label="mmgB CDS" gene complement(2026039..2026902) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /label="mmgB gene" CDS complement(2026927..2028108) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /EC_number="2.3.1.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16352833, 18246303, 19016856, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352833, 18246303, 19016856, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="degradative acetoacetyl-CoA thiolase" /protein_id="NP_390297.1" /db_xref="EnsemblGenomes-Gn:BSU24170" /db_xref="EnsemblGenomes-Tr:CAB14348" /db_xref="GOA:P45855" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="PDB:5LP7" /db_xref="SubtiList:BG11319" /db_xref="UniProtKB/Swiss-Prot:P45855" /translation="MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVS GDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMI RAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDE AIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATI LGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFD LEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQV H*" /label="mmgA CDS" gene complement(2026927..2028108) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /label="mmgA gene" downshifts complement(2027688) /Source="Nicolas_upshifts" /id="D1261" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17207" /MaxDrop="2.33167" /score="-0.949614429" /energy="-7.8" /TU="U1884" /idTUdmin="U1885" /TUdmin=550 /isTUend="FALSE" /label="downshifts" misc_feature complement(2027795..2027801) /Source="Nicolas_upshift_promotors" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2027798) /Source="Nicolas_upshifts" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2028022..2028122) /Source="Nicolas_upshift_promotors" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2028062) /Source="Nicolas_upshifts" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2028155..2028173) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2028173) /Source="Nicolas_upshifts" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2028189..2028194) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2028235..2028966) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /EC_number="3.1.4.46" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 14563871, 21966272, 22843846, 24373430, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 14563871, 21966272, 22843846, 24373430, 27780866; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycerophosphodiester phosphodiesterase (exolytic cleavage of individual teichoic acid monomer units)" /protein_id="NP_390298.2" /db_xref="EnsemblGenomes-Gn:BSU24180" /db_xref="EnsemblGenomes-Tr:CAB14349" /db_xref="GOA:P54527" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG11719" /db_xref="UniProtKB/Swiss-Prot:P54527" /translation="MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGR IVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKK DFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERA VLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMK RLIEAGADGMFTDFPEKASALLKNE*" /label="glpQ CDS" gene complement(2028235..2028966) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /label="glpQ gene" downshifts complement(2028242) /Source="Nicolas_upshifts" /id="D1262" /incds=0 /nref=31 /ntot=180 /MaxReadThrough="0.31166" /MaxDrop="4.10202" /score="-0.949614429" /energy="-7.8" /TU="NA" /idTUdmin="U1885" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2028989..2029008) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2029000) /Source="Nicolas_upshifts" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2029023..2029026) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2029045..2029665) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /EC_number="3.5.1.28" /experiment="publication(s) with functional evidences, PMID:22843846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22843846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390299.2" /db_xref="EnsemblGenomes-Gn:BSU24190" /db_xref="EnsemblGenomes-Tr:CAB14350" /db_xref="GOA:P54525" /db_xref="InterPro:IPR002508" /db_xref="SubtiList:BG11717" /db_xref="UniProtKB/Swiss-Prot:P54525" /translation="MRMLWRSLALCGLALTLAPCAQAAEPIEGKTVYIDAGHGGEDSG AVGNGLFEKDINLAVSEHVTDKLKEEGANPVASRSDDHFLTLEERVAKASANQADLFV SIHVNSGVASASGTETYFQSDYEGENSRRLASDIQSQLVSSLQTRDRGVKESDFYVIT YSQMPSVLAELGFITNSSDADKLGSEEYQQKAADAIVNGIDSYYDQ*" /label="yqiI CDS" gene complement(2029045..2029665) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /label="yqiI gene" CDS complement(2029680..2029973) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22843846; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390300.2" /db_xref="EnsemblGenomes-Gn:BSU24200" /db_xref="EnsemblGenomes-Tr:CAB14351" /db_xref="GOA:P40770" /db_xref="SubtiList:BG11030" /db_xref="UniProtKB/Swiss-Prot:P40770" /translation="MKQTVLLLFTALFLSGCSVASADDSVPRFTEEGKYIGSADPHTI AVSLNGEETMIQVPKDKRDECESLPDQTHVLVKYTKKDNGTLQLEDIQLRKNS*" /label="yqiH CDS" gene complement(2029680..2029973) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /label="yqiH gene" promotor_-10 complement(2029993..2030012) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2029999) /Source="Nicolas_upshifts" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2030027..2030034) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2030229..2030236 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2030250..2030269 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2030267..2030472 /Source="Nicolas_S_feature" /locus_tag="new_2516201_2516406" /HighExp="Diami, dia15, dia5, H2O2, Paraq, LBGexp, G180, LBGstat, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99653599999999998" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S911" upshifts 2030267 /Source="Nicolas_upshifts" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2030281..2030433 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513977.1" /translation="MKEVKAMKKFVLLLAAAVITCSIGHQISGGYKGPEKERPKHHSA LKIFSR*" /label="hypothetical protein CDS" gene 2030281..2030433 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /label="gene" promotor_-35 2030441..2030448 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2030463..2030482 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2030474 /Source="Nicolas_upshifts" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2030506..2031624 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-dependent flavin oxidoreductase" /protein_id="NP_390301.1" /db_xref="EnsemblGenomes-Gn:BSU24210" /db_xref="EnsemblGenomes-Tr:CAB14352" /db_xref="GOA:P54524" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11716" /db_xref="UniProtKB/Swiss-Prot:P54524" /translation="MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAE LDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAV VQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIE AGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAK GAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTR TRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEG REKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD*" /label="yqiG CDS" gene 2030506..2031624 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /label="yqiG gene" downshifts 2031609 /Source="Nicolas_upshifts" /id="D1263" /incds=0 /nref=23 /ntot=181 /MaxReadThrough="1.88324" /MaxDrop="6.67511" /score="30.8551972" /energy="-16.1" /TU="NA" /idTUdmin="U1887" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2031651..2031821) /Source="Nicolas_S_feature" /locus_tag="new_2517585_2517755_c" /HighExp="T0.30H, S6, S8, T1.30H, T1.0H, T-0.40H, S7, Salt, T0.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="1, 0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S912" downshifts complement(2031694) /Source="Nicolas_upshifts" /id="D1264" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="3.46085" /MaxDrop="2.69939" /score="-5.47428449" /energy="-16.1" /TU="U1889" /idTUdmin="U1890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2031805..2031820) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2031821) /Source="Nicolas_upshifts" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2031823..2031951) /Source="Nicolas_S_feature" /locus_tag="new_2517757_2517885_c" /HighExp="S6, S8, S7, S5, BT, M9-stat, B36, G180, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S913" promotor_-35 complement(2031832..2031841) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2031950..2031969) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2031973) /Source="Nicolas_upshifts" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2031983..2031991) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2032083) /Source="Nicolas_upshifts" /id="D1265" /incds=0 /nref=199 /ntot=267 /MaxReadThrough="2.54843" /MaxDrop="4.82417" /score="-1.10791055" /energy="-15.5" /TU="NA" /idTUdmin="U1891" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2032089..2032892) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT" /protein_id="NP_390302.1" /db_xref="EnsemblGenomes-Gn:BSU24220" /db_xref="EnsemblGenomes-Tr:CAB14353" /db_xref="GOA:P06534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR012052" /db_xref="InterPro:IPR014879" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1LQ1" /db_xref="SubtiList:BG10765" /db_xref="UniProtKB/Swiss-Prot:P06534" /translation="MEKIKVCVADDNRELVSLLSEYIEGQEDMEVIGVAYNGQECLSL FKEKDPDVLVLDIIMPHLDGLAVLERLRESDLKKQPNVIMLTAFGQEDVTKKAVDLGA SYFILKPFDMENLVGHIRQVSGNASSVTHRAPSSQSSIIRSSQPEPKKKNLDASITSI IHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRH AIEVAWSRGNIDSISSLFGYTVSMTKAKPTNSEFIAMVADKLRLEHKAS*" /label="spo0A CDS" gene complement(2032089..2032892) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /label="spo0A gene" promotor_-10 complement(2032935..2032953) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2032941) /Source="Nicolas_upshifts" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2032943..2033095) /Source="Nicolas_S_feature" /locus_tag="new_2518877_2519029_c" /HighExp="T1.30H, T3.0H, T2.30H, T2.0H, HiTm, Lbtran, T1.0H, T-0.40H, T0.30H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S914" promotor_-35 complement(2032964..2032972) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2033091..2033110) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2033103) /Source="Nicolas_upshifts" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2033122..2033129) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 2033137..2033138 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_005" CDS complement(2033198..2034928) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /function="16.8: Protect" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor for double strand breaks DNA repair and genetic recombination" /protein_id="NP_390304.2" /db_xref="EnsemblGenomes-Gn:BSU24240" /db_xref="EnsemblGenomes-Tr:CAB14355" /db_xref="GOA:P17894" /db_xref="InterPro:IPR004604" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10310" /db_xref="UniProtKB/Swiss-Prot:P17894" /translation="MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISL LVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSG KSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALK TYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQ QISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYY LLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEI DQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKS TFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGE LSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLP QVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELL KQADQVKTTG*" /label="recN CDS" gene complement(2033198..2034928) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /label="recN gene" downshifts complement(2033213) /Source="Nicolas_upshifts" /id="D1267" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="1.73202" /MaxDrop="6.33427" /score="20.028822" /energy="-12.4" /TU="NA" /idTUdmin="U1895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2034965..2035414) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AhrC(ArgR)-arginine)" /protein_id="NP_390305.1" /db_xref="EnsemblGenomes-Gn:BSU24250" /db_xref="EnsemblGenomes-Tr:CAB14356" /db_xref="GOA:P17893" /db_xref="InterPro:IPR001669" /db_xref="InterPro:IPR020899" /db_xref="InterPro:IPR020900" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR036251" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1F9N" /db_xref="PDB:2P5K" /db_xref="PDB:2P5L" /db_xref="PDB:2P5M" /db_xref="SubtiList:BG10309" /db_xref="UniProtKB/Swiss-Prot:P17893" /translation="MNKGQRHIKIREIITSNEIETQDELVDMLKQDGYKVTQATVSRD IKELHLVKVPTNNGSYKYSLPADQRFNPLSKLKRALMDAFVKIDSASHMIVLKTMPGN AQAIGALMDNLDWDEMMGTICGDDTILIICRTPEDTEGVKNRLLELL*" /label="argR CDS" gene complement(2034965..2035414) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /label="argR gene" S_feature complement(2035415..2035500) /Source="Nicolas_S_feature" /locus_tag="new_2522774_2522859_c" /HighExp="H2O2, G180, G135, G150, Oxctl, Heat, Paraq, C30, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S915" CDS complement(2035512..2036357) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /EC_number="2.1.1.-" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2'-O-ribose RNA methyltransferase" /protein_id="NP_390306.2" /db_xref="EnsemblGenomes-Gn:BSU24260" /db_xref="EnsemblGenomes-Tr:CAB14357" /db_xref="GOA:P19672" /db_xref="InterPro:IPR002877" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR004538" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10308" /db_xref="UniProtKB/Swiss-Prot:P19672" /translation="MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPG EKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQ NGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFIS LRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAA EGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKK ADVPE*" /label="yqxC CDS" gene complement(2035512..2036357) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /label="yqxC gene" downshifts complement(2035545) /Source="Nicolas_upshifts" /id="D1268" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="5.65358" /MaxDrop="2.6955" /score="4.97422627" /energy="-9.4" /TU="U1895,U1896,U1898" /idTUdmin="U1895" /TUdmin="-2332" /isTUend="FALSE" /label="downshifts" CDS complement(2036354..2038255) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /EC_number="2.2.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12882400, 15292217, 17458547, 23840410, 25212876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-deoxyxylulose-5-phosphate synthase" /protein_id="NP_390307.1" /db_xref="EnsemblGenomes-Gn:BSU24270" /db_xref="EnsemblGenomes-Tr:CAB14358" /db_xref="GOA:P54523" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005477" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11715" /db_xref="UniProtKB/Swiss-Prot:P54523" /translation="MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGP NLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKR SESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKL AATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHV ITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDG RIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTF LQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKD ENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILT FGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEG GFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMP PKTHKGIGS*" /label="dxs CDS" gene complement(2036354..2038255) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /label="dxs gene" promotor_-35 2037463..2037469 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2037484..2037495 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2037492 /Source="Nicolas_upshifts" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2038256..2038384) /Source="Nicolas_S_feature" /locus_tag="new_2525615_2525743_c" /HighExp="Salt, Heat, dia15, H2O2, HiOs, Cold, T-5.40H, T3.30H, SMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S916" promotor_-10 complement(2038379..2038398) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2038384) /Source="Nicolas_upshifts" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2038413..2038419) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2038430..2039320) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /EC_number="2.5.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755734, 12682299, 17147392, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate synthase" /protein_id="NP_390308.2" /db_xref="EnsemblGenomes-Gn:BSU24280" /db_xref="EnsemblGenomes-Tr:CAB14359" /db_xref="GOA:P54383" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG11714" /db_xref="UniProtKB/Swiss-Prot:P54383" /translation="MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAG GKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTN HKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQV ADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIG FQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGG LSLQKDLLYELCDLIAARDH*" /label="ispA CDS" gene complement(2038430..2039320) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /label="ispA gene" CDS complement(2039310..2039564) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /EC_number="3.1.11.6" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11381137, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (small subunit)" /protein_id="NP_390309.2" /db_xref="EnsemblGenomes-Gn:BSU24290" /db_xref="EnsemblGenomes-Tr:CAB14360" /db_xref="GOA:P54522" /db_xref="InterPro:IPR003761" /db_xref="InterPro:IPR037004" /db_xref="SubtiList:BG11713" /db_xref="UniProtKB/Swiss-Prot:P54522" /translation="MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGM ALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK*" /label="xseB CDS" gene complement(2039310..2039564) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /label="xseB gene" CDS complement(2039561..2040907) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /EC_number="3.1.11.6" /function="16.9: Replicate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17182742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (large subunit)" /protein_id="NP_390310.2" /db_xref="EnsemblGenomes-Gn:BSU24300" /db_xref="EnsemblGenomes-Tr:CAB14361" /db_xref="GOA:P54521" /db_xref="InterPro:IPR003753" /db_xref="InterPro:IPR020579" /db_xref="InterPro:IPR025824" /db_xref="SubtiList:BG11712" /db_xref="UniProtKB/Swiss-Prot:P54521" /translation="MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRG HIYFTLKDENARMQSVMFARQSERLPFKPENGMKVLVRGGISVYEPSGNYQLYAKEMQ PDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAAVRDVITTLK RRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEE IVARAIFASNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTA EVRMTRAMQQHLGQKKERIQTLQSSYAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLD RKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNIQMKQLHSQFQTVLGKL NALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK*" /label="xseA CDS" gene complement(2039561..2040907) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /label="xseA gene" S_feature complement(2040908..2041044) /Source="Nicolas_S_feature" /locus_tag="new_2528267_2528403_c" /HighExp="H2O2, G180, G135, Cold, G150, Paraq, Oxctl, LBGstat, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S917" CDS complement(2041045..2041896) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7061514, 9454603, 12682299, 19171795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase" /protein_id="NP_390311.1" /db_xref="EnsemblGenomes-Gn:BSU24310" /db_xref="EnsemblGenomes-Tr:CAB14362" /db_xref="GOA:P54382" /db_xref="InterPro:IPR000672" /db_xref="InterPro:IPR020630" /db_xref="InterPro:IPR020631" /db_xref="InterPro:IPR020867" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11711" /db_xref="UniProtKB/Swiss-Prot:P54382" /translation="MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDP ASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPD HISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKE VVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISAD QIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVK SAKRTLS*" /label="folD CDS" gene complement(2041045..2041896) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /label="folD gene" CDS complement(2041908..2042303) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16707701, 16946247, 27964882; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription termination factor NusB" /protein_id="NP_390312.2" /db_xref="EnsemblGenomes-Gn:BSU24320" /db_xref="EnsemblGenomes-Tr:CAB14363" /db_xref="GOA:P54520" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR011605" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG11710" /db_xref="UniProtKB/Swiss-Prot:P54520" /translation="MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQL VHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAI ELAKRFGDDKATKFVNGVLSNIKSDIEQS*" /label="nusB CDS" gene complement(2041908..2042303) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /label="nusB gene" misc_feature complement(2042346..2042365) /Source="Nicolas_upshift_promotors" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2042365) /Source="Nicolas_upshifts" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2042367..2042529) /Source="Nicolas_S_feature" /locus_tag="new_2529726_2529888_c" /HighExp="G180, G150, Oxctl, Etha, G135, GM 120, dia0, HPh, MG 150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S918" CDS complement(2042567..2042974) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 17114254, 22720735, 28579978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 17114254, 22720735, 28579978; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="alkaline shock protein" /protein_id="NP_390313.2" /db_xref="EnsemblGenomes-Gn:BSU24330" /db_xref="EnsemblGenomes-Tr:CAB14364" /db_xref="InterPro:IPR005531" /db_xref="SubtiList:BG11709" /db_xref="UniProtKB/Swiss-Prot:P54519" /translation="MKDNSLLKMDHEDTHLGKVEIAPEVIEVIAGIAASEVDGVAEMR GNFATGVVERFGKVNHGKGVKVDLADDGITIDVYCVVTFGVSIPKVAASVQENIRQTL LNMTSLSINEINIHIVGIQFDTKAQEVQIDEEM*" /label="yqhY CDS" gene complement(2042567..2042974) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /label="yqhY gene" downshifts complement(2042574) /Source="Nicolas_upshifts" /id="D1269" /incds=0 /nref=6 /ntot=76 /MaxReadThrough="6.4099" /MaxDrop="4.1473" /score="9.44795832" /energy="-9.5" /TU="U1897,U1898" /idTUdmin="U1899" /TUdmin=2409 /isTUend="FALSE" /label="downshifts" CDS complement(2042995..2044347) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /EC_number="6.3.4.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxylase subunit)" /protein_id="NP_390314.2" /db_xref="EnsemblGenomes-Gn:BSU24340" /db_xref="EnsemblGenomes-Tr:CAB14365" /db_xref="GOA:P49787" /db_xref="InterPro:IPR004549" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11384" /db_xref="UniProtKB/Swiss-Prot:P49787" /translation="MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQM ADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTF VGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNY GNTIHLGERDCSIQRRLQKLLEESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEF IYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGW AIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVIT YGKTRDEAIARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS *" /label="accC CDS" gene complement(2042995..2044347) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /label="accC gene" promotor_-10 complement(2043876..2043895) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-10" upshifts complement(2043883) /Source="Nicolas_upshifts" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="upshifts" promotor_-35 complement(2043910..2043916) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-35" CDS complement(2044359..2044838) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796, 15518551" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796, 15518551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit)" /protein_id="NP_390315.1" /db_xref="EnsemblGenomes-Gn:BSU24350" /db_xref="EnsemblGenomes-Tr:CAB14366" /db_xref="GOA:P49786" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001249" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG11383" /db_xref="UniProtKB/Swiss-Prot:P49786" /translation="MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVM QQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGP YVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE* " /label="accB CDS" gene complement(2044359..2044838) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /label="accB gene" promotor_-10 complement(2044897..2044916) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2044908) /Source="Nicolas_upshifts" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2044930..2044937) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2044994..2045650) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15028710, 15752199, 16959571, 1766372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15028710, 15752199, 16959571, 1766372; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation ratchet engulfment protein" /protein_id="NP_390316.2" /db_xref="EnsemblGenomes-Gn:BSU24360" /db_xref="EnsemblGenomes-Tr:CAB14367" /db_xref="GOA:P49785" /db_xref="InterPro:IPR024232" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11415" /db_xref="UniProtKB/Swiss-Prot:P49785" /translation="MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDS GEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETAD DDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLET LIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK *" /label="spoIIIAH CDS" gene complement(2044994..2045650) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /label="spoIIIAH gene" downshifts complement(2045001) /Source="Nicolas_upshifts" /id="D1270" /incds=0 /nref=26 /ntot=57 /MaxReadThrough="0.0903599999999987" /MaxDrop="6.40434" /score="21.0450747" /energy="-13" /TU="NA" /idTUdmin="U1899" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" CDS complement(2045651..2046340) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation engulfment assembly protein" /protein_id="NP_390317.2" /db_xref="EnsemblGenomes-Gn:BSU24370" /db_xref="EnsemblGenomes-Tr:CAB14368" /db_xref="GOA:P49784" /db_xref="InterPro:IPR014195" /db_xref="SubtiList:BG11414" /db_xref="UniProtKB/Swiss-Prot:P49784" /translation="MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFM LVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYEN QLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSE EEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRV AVAPKKIKEDS*" /label="spoIIIAG CDS" gene complement(2045651..2046340) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /label="spoIIIAG gene" CDS complement(2046333..2046953) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390318.1" /db_xref="EnsemblGenomes-Gn:BSU24380" /db_xref="EnsemblGenomes-Tr:CAB14369" /db_xref="GOA:P49783" /db_xref="InterPro:IPR014245" /db_xref="SubtiList:BG11413" /db_xref="UniProtKB/Swiss-Prot:P49783" /translation="MSFLTEWLTTIVLFILFAIVIDMLLPSSSMQKYAKMVVSLLLIV VMLTPIFKLFKTDPEVIFEYLTKNGQSESADIKNQINSKKIEIQASQRAYILEEMAVQ LKKKAEERFSHDEYKVGRIKLTAGEKVDSEEDIKTISVYMAPSSEKTVQTVAPVHIDT DHAYVTKEAAEQKEAKQIQTQLADIWEIGSEKITVHMEGGESVGNE*" /label="spoIIIAF CDS" gene complement(2046333..2046953) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /label="spoIIIAF gene" promotor_-10 complement(2046659..2046677) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2046677) /Source="Nicolas_upshifts" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2046693..2046698) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2046967..2048166) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390319.2" /db_xref="EnsemblGenomes-Gn:BSU24390" /db_xref="EnsemblGenomes-Tr:CAB14370" /db_xref="GOA:P49782" /db_xref="InterPro:IPR014194" /db_xref="SubtiList:BG11412" /db_xref="UniProtKB/Swiss-Prot:P49782" /translation="MKRFQWVLLLAVLIIAGRAEIVQAAGNAEQTEDHAETAEQLAER TAASLETDKIGEFWNDIMTEYGGLLPESQKGSLMEFINGDKSFSPQEWLKALFSYLFH EVLANGKLLGTLILLTIFCVILQLLQNAFQQSTVSKVAYSIVYMVLIILALNSFHVAI NYATEAIQTMTSFILALIPLLLALLASSGGAVSAAFFHPVILFLMNTSGLLIQNIVMP LIFLSAILSIVSTMTEQYKVTQLANLLRNIAIGALAVFLTIFLGVISVQGASAAVTDG ITLRTAKFITGNFIPVLGRMFTDATDTVISASLLLKNTVGILGVAILICIAAFPAIKV LSLAFIYKLAAAILQPLGGGPVITCLDVISKSVIYIFAALAIVSLMFFLSLTVIITAG NLTMMMK*" /label="spoIIIAE CDS" gene complement(2046967..2048166) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /label="spoIIIAE gene" CDS complement(2048185..2048586) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390320.1" /db_xref="EnsemblGenomes-Gn:BSU24400" /db_xref="EnsemblGenomes-Tr:CAB14371" /db_xref="GOA:P49781" /db_xref="InterPro:IPR014211" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11411" /db_xref="UniProtKB/Swiss-Prot:P49781" /translation="MQIDIVQIVGLGLIATFLSLIVKEQKPTFAFLIVVFAGCAIFLY LVDQIYDIIRMIEKIAINANVNMVYVETILKIIGIAYIAEFGAQLTKDAGQGAIASKI ELAGKILILVMAVPILTVIIETILGLIPSMS*" /label="spoIIIAD CDS" gene complement(2048185..2048586) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /label="spoIIIAD gene" CDS complement(2048593..2048799) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390321.1" /db_xref="EnsemblGenomes-Gn:BSU24410" /db_xref="EnsemblGenomes-Tr:CAB14372" /db_xref="GOA:P49780" /db_xref="InterPro:IPR009570" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11410" /db_xref="UniProtKB/Swiss-Prot:P49780" /translation="MGVDVNVIFQIAGVGIVVAFLHTILDQMGKKEYAQWVTLLGFIY ILFMVATIVDDLFKKIKAVFLFQG*" /label="spoIIIAC CDS" gene complement(2048593..2048799) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /label="spoIIIAC gene" CDS complement(2048822..2049337) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390322.1" /db_xref="EnsemblGenomes-Gn:BSU24420" /db_xref="EnsemblGenomes-Tr:CAB14373" /db_xref="GOA:Q01368" /db_xref="InterPro:IPR014198" /db_xref="SubtiList:BG10541" /db_xref="UniProtKB/Swiss-Prot:Q01368" /translation="MLKLLGAVFIVVATTWTGFEMAKIYTERPRQIRQLRAALQSLEA EIMYGHTPLHTASQQIAKQLAQPVSTLFSAFSDQLDKGSDSAKTAWEQSLKKVWDTLS LKKSEYEVLKQFGETLGIHDRISQQKHIKLALTHLEASEADAEQAQAKNEKMIKSLGF LAGLLLILLLM*" /label="spoIIIAB CDS" gene complement(2048822..2049337) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /label="spoIIIAB gene" CDS complement(2049331..2050254) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATP-binding stage III sporulation protein" /protein_id="NP_390323.1" /db_xref="EnsemblGenomes-Gn:BSU24430" /db_xref="EnsemblGenomes-Tr:CAB14374" /db_xref="GOA:Q01367" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014217" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10540" /db_xref="UniProtKB/Swiss-Prot:Q01367" /translation="MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRG QPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGG VKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLS STGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSP EVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYL ELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC*" /label="spoIIIAA CDS" gene complement(2049331..2050254) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /label="spoIIIAA gene" S_feature complement(2050255..2050329) /Source="Nicolas_S_feature" /locus_tag="new_2537614_2537688_c" /HighExp="S3, LoTm, S4, T5.0H, M9-stat, S5, BT, S7, S6, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S919" CDS complement(2050330..2050611) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390324.1" /db_xref="EnsemblGenomes-Gn:BSU24440" /db_xref="EnsemblGenomes-Tr:CAB14375" /db_xref="GOA:P49779" /db_xref="InterPro:IPR020390" /db_xref="SubtiList:BG11459" /db_xref="UniProtKB/Swiss-Prot:P49779" /translation="MKFLLGNINSTVLTMAGLRVLSSMIELTAAIVMLVTNDVRKAVV VNSILAIVGPLIFIITMTVGIYQIAGQLSYAKLILIFTGVVLILAGVHK*" /label="yqhV CDS" gene complement(2050330..2050611) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /label="yqhV gene" promotor_-10 complement(2050631..2050649) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-10" upshifts complement(2050654) /Source="Nicolas_upshifts" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="upshifts" promotor_-35 complement(2050665..2050670) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-35" CDS complement(2050756..2051313) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor P" /protein_id="NP_390325.2" /db_xref="EnsemblGenomes-Gn:BSU24450" /db_xref="EnsemblGenomes-Tr:CAB14376" /db_xref="GOA:P49778" /db_xref="InterPro:IPR001059" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR011768" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013185" /db_xref="InterPro:IPR013852" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015365" /db_xref="InterPro:IPR020599" /db_xref="SubtiList:BG11460" /db_xref="UniProtKB/Swiss-Prot:P49778" /translation="MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNL RTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSATQIEEEL KYLLENMSVHIMMYQDETLGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVV NVPFFVNEGDTLVVNTSDGSYVSRA*" /label="efp CDS" gene complement(2050756..2051313) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /label="efp gene" downshifts complement(2050768) /Source="Nicolas_upshifts" /id="D1271" /incds=0 /nref=256 /ntot=266 /MaxReadThrough="0.83852" /MaxDrop="7.73118" /score="27.4193827" /energy="-13.5" /TU="NA" /idTUdmin="U1901" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2051338..2052399) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /EC_number="3.4.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23144141, 26735940, 27002156" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23144141, 26735940, 27002156; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase (Met-Xaa and Xaa-Pro, Xaa-Pro-Xaa)" /protein_id="NP_390326.1" /db_xref="EnsemblGenomes-Gn:BSU24460" /db_xref="EnsemblGenomes-Tr:CAB14377" /db_xref="GOA:P54518" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG11708" /db_xref="UniProtKB/Swiss-Prot:P54518" /translation="MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGD KAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTY ASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISE IAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYK GYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKG YGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIV ITENGNRTITHSPKELIIL*" /label="papA CDS" gene complement(2051338..2052399) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /label="papA gene" CDS complement(2052396..2052842) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10870960, 19099550; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase, type II" /protein_id="NP_390327.1" /db_xref="EnsemblGenomes-Gn:BSU24470" /db_xref="EnsemblGenomes-Tr:CAB14378" /db_xref="GOA:P54517" /db_xref="InterPro:IPR001874" /db_xref="InterPro:IPR018509" /db_xref="InterPro:IPR036441" /db_xref="PDB:1GQO" /db_xref="SubtiList:BG11707" /db_xref="UniProtKB/Swiss-Prot:P54517" /translation="MPHFLILNGPNVNRLGSREPEVFGRQTLTDIETDLFQFAEALHI QLTFFQSNHEGDLIDAIHEAEEQYSGIVLNPGALSHYSYAIRDAVSSISLPVVEVHLS NLYAREEFRHQSVIAPVAKGQIVGLGAEGYKLAVRYLLSQQGGESR*" /label="yqhS CDS" gene complement(2052396..2052842) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /label="yqhS gene" promotor_-10 complement(2052891..2052910) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2052907) /Source="Nicolas_upshifts" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2052923..2052930) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2052929..2053465) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390328.1" /db_xref="EnsemblGenomes-Gn:BSU24480" /db_xref="EnsemblGenomes-Tr:CAB14379" /db_xref="GOA:P54516" /db_xref="InterPro:IPR024563" /db_xref="SubtiList:BG11706" /db_xref="UniProtKB/Swiss-Prot:P54516" /translation="MMTSEKDTEQNEELNEKQKPPVSMAGRVAATGFCGGVLWSFVAY IAYLFHFSEISPNMILQPFVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKT MWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIYLLYGLFVGYSISFE YNELNSEKLARALGMHRE*" /label="yqhR CDS" gene complement(2052929..2053465) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /label="yqhR gene" promotor_-10 complement(2053478..2053489) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-10" upshifts complement(2053487) /Source="Nicolas_upshifts" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="upshifts" promotor_-35 complement(2053503..2053509) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-35" promotor_-35 2053535..2053541 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2053554 /Source="Nicolas_upshifts" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2053556..2053574 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2053611..2053614 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2053629..2053648 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2053640 /Source="Nicolas_upshifts" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" CDS 2053692..2054648 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390329.2" /db_xref="EnsemblGenomes-Gn:BSU24490" /db_xref="EnsemblGenomes-Tr:CAB14380" /db_xref="GOA:P54515" /db_xref="InterPro:IPR010787" /db_xref="SubtiList:BG11705" /db_xref="UniProtKB/Swiss-Prot:P54515" /translation="MSKHKVPPAYGGQAVVEGVMFGGKHHYVTAIRRTDGSIDFFKLP RKHNPKLNIVKKIPFLRGIAAIIEASANGTKHLNFSSERYGLDPSEDETLEQEEKKSS GLSMYLSLAVIGVLSFLFSKFVFTLVPVFLAELTRPIFSLNTAQIAIESLFKLILLLG YIYFLSMTPLIKRVFQYHGAEHKVINCYEQNLPITVENVQNQSRLHYRCGSSFILFTI IVGMFVYLLVPTDPLWLRVIDRVALIPVVLGISFEVLQLTNKVRDIPGLKLLGYPGLW LQLLTTKEPKDEQVEVAIESFNELLRLEALSEQNQKPSHNVI*" /label="yqhQ CDS" gene 2053692..2054648 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /label="yqhQ gene" CDS 2054688..2055083 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390330.1" /db_xref="EnsemblGenomes-Gn:BSU24500" /db_xref="EnsemblGenomes-Tr:CAB14381" /db_xref="GOA:P54514" /db_xref="SubtiList:BG11704" /db_xref="UniProtKB/Swiss-Prot:P54514" /translation="MNHRVQPIIAVLIALGAFGFLYVLVTNPGEMAKMAVTVIVAGII IYFIVKYVMNRNAGSEGAAFKKAAKQSRRRMKEQKAKHRAGHKGRVSHLRSVPSASKP KPMILKKKSQTQLTVIEGKKNKKKNRALF*" /label="yqhP CDS" gene 2054688..2055083 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /label="yqhP gene" promotor_no_box 2054966..2055066 /Source="Nicolas_upshift_promotors" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2055026 /Source="Nicolas_upshifts" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2055069 /Source="Nicolas_upshifts" /id="D1272" /incds=0 /nref=116 /ntot=283 /MaxReadThrough="2.23161" /MaxDrop="5.94415" /score="29.0609078" /energy="-8" /TU="NA" /idTUdmin="U1903" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2055080..2055955) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipase / acyl esterase" /protein_id="NP_390331.1" /db_xref="EnsemblGenomes-Gn:BSU24510" /db_xref="EnsemblGenomes-Tr:CAB14382" /db_xref="GOA:P54513" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG11703" /db_xref="UniProtKB/Swiss-Prot:P54513" /translation="MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIA AFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWI ADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMS CSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKK NIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIE LGKRRTELFLKQWTY*" /label="yqhO CDS" gene complement(2055080..2055955) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /label="yqhO gene" promotor_-10 complement(2055982..2056000) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2055999) /Source="Nicolas_upshifts" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2056016..2056021) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2056081..2056509) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)" /protein_id="NP_390332.2" /db_xref="EnsemblGenomes-Gn:BSU24520" /db_xref="EnsemblGenomes-Tr:CAB14383" /db_xref="GOA:P54512" /db_xref="InterPro:IPR001367" /db_xref="InterPro:IPR022687" /db_xref="InterPro:IPR022689" /db_xref="InterPro:IPR022897" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036421" /db_xref="PDB:1ON1" /db_xref="PDB:1ON2" /db_xref="PDB:2EV0" /db_xref="PDB:2EV5" /db_xref="PDB:2EV6" /db_xref="PDB:2F5C" /db_xref="PDB:2F5D" /db_xref="PDB:2F5E" /db_xref="PDB:2F5F" /db_xref="PDB:2HYF" /db_xref="PDB:2HYG" /db_xref="PDB:3R60" /db_xref="PDB:3R61" /db_xref="PDB:4HV5" /db_xref="PDB:4HV6" /db_xref="PDB:4HX4" /db_xref="PDB:4HX7" /db_xref="PDB:4HX8" /db_xref="SubtiList:BG11702" /db_xref="UniProtKB/Swiss-Prot:P54512" /translation="MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQ KLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIE HHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ*" /label="mntR CDS" gene complement(2056081..2056509) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /label="mntR gene" downshifts complement(2056108) /Source="Nicolas_upshifts" /id="D1273" /incds=0 /nref=322 /ntot=333 /MaxReadThrough="2.568" /MaxDrop="7.28707" /score="15.888362" /energy="-12" /TU="NA" /idTUdmin="U1908" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2056544..2056563) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2056552) /Source="Nicolas_upshifts" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2056579..2056583) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2056609..2057445) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /EC_number="2.3.1.181" /function="3: Fatty acid and phospholipid metabolism" /experiment="publication(s) with functional evidences, PMID:20882995, 21338420, 21338421, 23960015" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20882995, 21338420, 21338421, 23960015; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein octanoyltransferase" /protein_id="NP_390333.1" /db_xref="EnsemblGenomes-Gn:BSU24530" /db_xref="EnsemblGenomes-Tr:CAB14384" /db_xref="GOA:P54511" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024898" /db_xref="SubtiList:BG11701" /db_xref="UniProtKB/Swiss-Prot:P54511" /translation="MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGW NPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEM PATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELV VEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVA INELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNY KR*" /label="lipM CDS" gene complement(2056609..2057445) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /label="lipM gene" promotor_-10 complement(2057469..2057488) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2057480) /Source="Nicolas_upshifts" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2057482..2058026) /Source="Nicolas_S_feature" /locus_tag="new_2544841_2545385_c" /HighExp="Lbstat, LPhT, HiOs, M0t90, S1, M40t90, Sw, S0, B36, BC" /AntisenseName="yqhL" /AntisenseCor="-0.136624541005539" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S920" promotor_-35 complement(2057502..2057509) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2057526..2057531 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2057545..2057564 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2057545 /Source="Nicolas_upshifts" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="upshifts" S_feature 2057556..2057635 /Source="Nicolas_S_feature" /locus_tag="new_2544915_2544994" /HighExp="dia15, H2O2, dia5, Diami, MG-0.2, G180, UNK1, LBGexp, Heat, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S921" CDS 2057636..2058016 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11092948; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390334.2" /db_xref="EnsemblGenomes-Gn:BSU24540" /db_xref="EnsemblGenomes-Tr:CAB14385" /db_xref="GOA:P54510" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11700" /db_xref="UniProtKB/Swiss-Prot:P54510" /translation="MSNMIVLIIFAAFIIYMIASYVYQQRIMKTLTEEEFRAGYRKAQ LIDVREPNEFEGGHILGARNIPLSQLKQRKNEIRTDKPVYLYCQNSVRSGRAAQTLRK NGCTEIYNLKGGFKKWGGKIKAKK*" /label="yqhL CDS" gene 2057636..2058016 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /label="yqhL gene" downshifts 2057952 /Source="Nicolas_upshifts" /id="D1274" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17088" /MaxDrop="3.92673" /score="27.1863605" /energy="-12" /TU="U1909" /idTUdmin="U1909" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2057996 /Source="Nicolas_upshifts" /id="D1275" /incds=0 /nref=213 /ntot=249 /MaxReadThrough="2.26861" /MaxDrop="6.03848" /score="27.1863605" /energy="-12" /TU="NA" /idTUdmin="U1909" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2058051..2059517) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8181752, 20011599, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8181752, 20011599, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 2) (glycine cleavage system protein P)" /protein_id="NP_390335.1" /db_xref="EnsemblGenomes-Gn:BSU24550" /db_xref="EnsemblGenomes-Tr:CAB14386" /db_xref="GOA:P54377" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023012" /db_xref="SubtiList:BG11511" /db_xref="UniProtKB/Swiss-Prot:P54377" /translation="MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDE DAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIH PLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTN PNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFT GPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGIN VRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKK LGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKE AEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER*" /label="gcvPB CDS" gene complement(2058051..2059517) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /label="gcvPB gene" downshifts complement(2058071) /Source="Nicolas_upshifts" /id="D1276" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="3.45831" /MaxDrop="4.3142" /score="0.884126414" /energy="-12" /TU="U1911" /idTUdmin="U1911" /TUdmin="-1517" /isTUend="FALSE" /label="downshifts" CDS complement(2059510..2060856) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8181752, 20011599, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 1) (glycine cleavage system protein P)" /protein_id="NP_390336.2" /db_xref="EnsemblGenomes-Gn:BSU24560" /db_xref="EnsemblGenomes-Tr:CAB14387" /db_xref="GOA:P54376" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023010" /db_xref="SubtiList:BG11510" /db_xref="UniProtKB/Swiss-Prot:P54376" /translation="MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQI KKAKSETELTRELTKLASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTP YQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFG RIEPLKDIEPIAHQGKSMFIVSANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGP HCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIRRDKATSNICSNQAL NALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDE PVRAVNKRLLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE*" /label="gcvPA CDS" gene complement(2059510..2060856) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /label="gcvPA gene" CDS complement(2060886..2061974) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /EC_number="2.1.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8219277, 15472076, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8219277, 15472076, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminomethyltransferase (glycine cleavage system protein T)" /protein_id="NP_390337.2" /db_xref="EnsemblGenomes-Gn:BSU24570" /db_xref="EnsemblGenomes-Tr:CAB14388" /db_xref="GOA:P54378" /db_xref="InterPro:IPR006222" /db_xref="InterPro:IPR006223" /db_xref="InterPro:IPR013977" /db_xref="InterPro:IPR022903" /db_xref="InterPro:IPR028896" /db_xref="InterPro:IPR029043" /db_xref="PDB:1YX2" /db_xref="SubtiList:BG11509" /db_xref="UniProtKB/Swiss-Prot:P54378" /translation="MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAA GLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQ KGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTD ADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAY GLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQ KENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSET SEIGTVVDVEIRKKLVKAKVVKTPFYKR*" /label="gcvT CDS" gene complement(2060886..2061974) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /label="gcvT gene" misc_RNA complement(2062048..2062247) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /product="dual aptamer glycine riboswitch" /experiment="publication(s) with functional evidences, PMID:15472076, 21439473, 23249744, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15472076, 21439473, 23249744, 23721735, 29089431; Product type n: RNA" /label="swgA RNA" gene complement(2062048..2062247) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /label="swgA gene" downshifts complement(2062098) /Source="Nicolas_upshifts" /id="D1277" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="6.79606" /MaxDrop="3.0322" /score="21.5485037" /energy="-20.2" /TU="U1911" /idTUdmin="U1915" /TUdmin=3630 /isTUend="FALSE" /label="downshifts" S_feature complement(2062248..2062318) /Source="Nicolas_S_feature" /locus_tag="new_2549607_2549677_c" /HighExp="B60, S8, S6, B36, S7, M9-stat, Sw, T3.0H, HiOs, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S922" promotor_-35 2062251..2062256 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2062272..2062290 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2062276 /Source="Nicolas_upshifts" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2062286..2062415 /Source="Nicolas_S_feature" /locus_tag="new_2549645_2549774" /HighExp="S4, S8, S7, S3, S5, S6, LoTm, T5.0H, T4.0H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.83" /TUlongSig="NA" /TUlongPSig="NA" /label="S923" promotor_-10 complement(2062304..2062323) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-10" upshifts complement(2062318) /Source="Nicolas_upshifts" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="upshifts" promotor_-35 complement(2062337..2062344) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-35" CDS 2062416..2064089 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /EC_number="3.6.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA polymerase-associated helicase protein" /protein_id="NP_390338.1" /db_xref="EnsemblGenomes-Gn:BSU24580" /db_xref="EnsemblGenomes-Tr:CAB14389" /db_xref="GOA:P54509" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11699" /db_xref="UniProtKB/Swiss-Prot:P54509" /translation="MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIP EFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMI RGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPH REIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLV SLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVET VPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKE KQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFL QQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPW NPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDIL TKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS*" /label="yqhH CDS" gene 2062416..2064089 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /label="yqhH gene" CDS 2064110..2064904 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390339.1" /db_xref="EnsemblGenomes-Gn:BSU24590" /db_xref="EnsemblGenomes-Tr:CAB14390" /db_xref="InterPro:IPR024562" /db_xref="SubtiList:BG11698" /db_xref="UniProtKB/Swiss-Prot:P54508" /translation="MRQQEVHDFLLRFFQANSCQIVDQGLGYMTVQLTVEMDKQIMNR PFYWHWREKTGGDPNPMKITFITDKENAPKDLDGEFIYFGAPRLFQIFKAVKQNGRFT RMYEKIESAGAKVPLQPWLGINVTISYQSDMKKDKLLSLGLHLVSGTIIEDFQSKLTQ FSLTSQICDYCFTISPMIKPESGLKRMENYISKSAMQEPSDWAEQAVNRWKNDMTLLD KFYEHIEEKPEEYHLEKQALKTLYQPKISVEIENGGLFYLQNNISS*" /label="yqhG CDS" gene 2064110..2064904 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /label="yqhG gene" misc_feature 2064440..2064441 /Source="Nicolas_upshift_promotors" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2064446 /Source="Nicolas_upshifts" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="upshifts" promotor_-35 2064928..2064931 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2064947..2064966 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2064948..2065086 /Source="Nicolas_S_feature" /locus_tag="new_2552307_2552445" /HighExp="LoTm, S4, S5, T5.0H, M9-stat, S3, B60, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.843, 0.83" /TUlongSig="SigA" /TUlongPSig="0.541" /label="S924" upshifts 2064948 /Source="Nicolas_upshifts" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2065087..2065260 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antagonist of SinR" /protein_id="NP_390340.1" /db_xref="EnsemblGenomes-Gn:BSU24600" /db_xref="EnsemblGenomes-Tr:CAB14391" /db_xref="GOA:P23308" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="SubtiList:BG10753" /db_xref="UniProtKB/Swiss-Prot:P23308" /translation="MKNAKQEHFELDQEWVELMVEAKEANISPEEIRKYLLLNKKSAH PGPAARSHTVNPF*" /label="sinI CDS" gene 2065087..2065260 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /label="sinI gene" promotor_-35 2065245..2065249 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2065262..2065281 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2065262 /Source="Nicolas_upshifts" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2065294..2065629 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator of biofilm formation" /protein_id="NP_390341.1" /db_xref="EnsemblGenomes-Gn:BSU24610" /db_xref="EnsemblGenomes-Tr:CAB14392" /db_xref="GOA:P06533" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="PDB:2YAL" /db_xref="PDB:3QQ6" /db_xref="PDB:3ZKC" /db_xref="SubtiList:BG10754" /db_xref="UniProtKB/Swiss-Prot:P06533" /translation="MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSI QFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQ KWRKSQKEE*" /label="sinR CDS" gene 2065294..2065629 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /label="sinR gene" downshifts 2065606 /Source="Nicolas_upshifts" /id="D1278" /incds=0 /nref=21 /ntot=181 /MaxReadThrough="4.7611" /MaxDrop="6.41889" /score="2.30357781" /energy="-20" /TU="U1913,U1914" /idTUdmin="U1910" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts 2065696 /Source="Nicolas_upshifts" /id="D1279" /incds=0 /nref=1 /ntot=85 /MaxReadThrough="2.4376" /MaxDrop="4.25363" /score="58.1462301" /energy="-26.8" /TU="NA" /idTUdmin="U1913" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts complement(2065728) /Source="Nicolas_upshifts" /id="D1280" /incds=0 /nref=144 /ntot=227 /MaxReadThrough="4.33009" /MaxDrop="8.70948" /score="10.0483516" /energy="-20" /TU="NA" /idTUdmin="U1915" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(2065745,2065752) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27" N_region 2065746..2065751 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs27" promotor_-35 2065821..2065827 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2065828 /Source="Nicolas_upshifts" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2065841..2065852 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2065871..2066197 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390345.1" /db_xref="EnsemblGenomes-Gn:BSU24650" /db_xref="EnsemblGenomes-Tr:CAB14396" /db_xref="InterPro:IPR024987" /db_xref="PDB:2LYX" /db_xref="SubtiList:BG13773" /db_xref="UniProtKB/Swiss-Prot:O32019" /translation="MMIKQCVICLSLLVFGTTAAHAEETPLVTARHMSKWEEIAVKEA KKRYPLAQVLFKQKVWDRKRKDEAVKQYHLTLREGSKEFGVFVTISFDPYSQKVNKIA ILEEYQ*" /label="yqzG CDS" gene 2065871..2066197 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /label="yqzG gene" S_feature complement(2066014..2066238) /Source="Nicolas_S_feature" /locus_tag="new_2555662_2555886_c" /HighExp="GM 150, G/S, C30, T-4.40H, S8, T-3.40H, Pyr, S7, S2, C90" /AntisenseName="yqzG" /AntisenseCor="0.536702817178903" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.549, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S925" downshifts complement(2066057) /Source="Nicolas_upshifts" /id="D1281" /incds=1 /nref=92 /ntot=160 /MaxReadThrough="2.23218" /MaxDrop="5.56661" /score="31.27773" /energy="-10.2" /TU="NA" /idTUdmin="U1918" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2066179 /Source="Nicolas_upshifts" /id="D1282" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="2.14107" /MaxDrop="4.98052" /score="-9.62570043" /energy="-15.1" /TU="NA" /idTUdmin="U1917" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2066239..2066418) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="factor involved in sporulation" /protein_id="NP_390346.2" /db_xref="EnsemblGenomes-Gn:BSU24660" /db_xref="EnsemblGenomes-Tr:CAB14397" /db_xref="InterPro:IPR025622" /db_xref="SubtiList:BG13771" /db_xref="UniProtKB/Swiss-Prot:O32020" /translation="MKTNDYVKYMTQQFVKYIDTPRDERKERKEVRKETKTPVSQQWF GILPYGFRLWLKRKK*" /label="spoIIT CDS" gene complement(2066239..2066418) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /label="spoIIT gene" promotor_-10 complement(2066437..2066455) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2066452) /Source="Nicolas_upshifts" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2066470..2066476) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2066489..2066863) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406, 24164455; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390347.1" /db_xref="EnsemblGenomes-Gn:BSU24670" /db_xref="EnsemblGenomes-Tr:CAB14398" /db_xref="GOA:P25959" /db_xref="InterPro:IPR020372" /db_xref="SubtiList:BG10489" /db_xref="UniProtKB/Swiss-Prot:P25959" /translation="MYRTRGFIYPAVLFVSALVLLIVNFVAAQYISRCMFEKETKELY IGENLLQNGVLLSIRHVLEERKGQEGTQQFLYGRVSYYIHDTSIKEQKEINLRVSTDS GTERTAQIVFDQKQKKLLRWTE*" /label="comGG CDS" gene complement(2066489..2066863) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /label="comGG gene" CDS complement(2066864..2067247) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390348.1" /db_xref="EnsemblGenomes-Gn:BSU24680" /db_xref="EnsemblGenomes-Tr:CAB14399" /db_xref="GOA:P25958" /db_xref="InterPro:IPR016977" /db_xref="SubtiList:BG10488" /db_xref="UniProtKB/Swiss-Prot:P25958" /translation="MLISGSLAAIIHLFLSRQQEHDGFTQQEWMISIEQMMNECKESQ AVKTAEHGSVLICTNLSGQDIRFDIYHSMIRKRVDGKGHVPILDHITAMKADIENGVV LLKIESEDQKVYQTAFPVYSYLGGG*" /label="comGF CDS" gene complement(2066864..2067247) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /label="comGF gene" CDS complement(2067273..2067620) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /function="16.11: Scavenge (Catabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7783624, 9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390349.1" /db_xref="EnsemblGenomes-Gn:BSU24690" /db_xref="EnsemblGenomes-Tr:CAB14400" /db_xref="GOA:P25957" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR020488" /db_xref="SubtiList:BG10487" /db_xref="UniProtKB/Swiss-Prot:P25957" /translation="MWRENKGFSTIETMSALSLWLFVLLTVVPLWDKLMADEKMAESR EIGYQMMNESISKYVMSGEGAASKTITKNNHIYAMKWEEEGEYQNVCIKAAAYKEKSF CLSILQTEWLHAS*" /label="comGE CDS" gene complement(2067273..2067620) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /label="comGE gene" CDS complement(2067604..2068035) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane component of the DNA transport pilin platform" /protein_id="NP_390350.1" /db_xref="EnsemblGenomes-Gn:BSU24700" /db_xref="EnsemblGenomes-Tr:CAB14401" /db_xref="GOA:P25956" /db_xref="InterPro:IPR002416" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016785" /db_xref="SubtiList:BG10486" /db_xref="UniProtKB/Swiss-Prot:P25956" /translation="MNIKLNEEKGFTLLESLLVLSLASILLVAVFTTLPPAYDNTAVR QAASQLKNDIMLTQQTAISRQQRTKILFHKKEYQLVIGDTVIERPYATGLSIELLTLK DRLEFNEKGHPNAGGKIRVKGHAVYDITVYLGSGRVNVERK*" /label="comGD CDS" gene complement(2067604..2068035) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /label="comGD gene" CDS complement(2068025..2068321) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="pilin-like component of the DNA transport membrane pilin platform" /protein_id="NP_390351.1" /db_xref="EnsemblGenomes-Gn:BSU24710" /db_xref="EnsemblGenomes-Tr:CAB14402" /db_xref="GOA:P25955" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016940" /db_xref="SubtiList:BG10485" /db_xref="UniProtKB/Swiss-Prot:P25955" /translation="MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGL QNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH*" /label="comGC CDS" gene complement(2068025..2068321) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /label="comGC gene" CDS complement(2068335..2069306) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 15968048, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 15968048, 16850406, 24164455; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane pilin platform component of the DNA transport machinery" /protein_id="NP_390352.1" /db_xref="EnsemblGenomes-Gn:BSU24720" /db_xref="EnsemblGenomes-Tr:CAB14403" /db_xref="GOA:P25954" /db_xref="InterPro:IPR001992" /db_xref="InterPro:IPR018076" /db_xref="SubtiList:BG10484" /db_xref="UniProtKB/Swiss-Prot:P25954" /translation="MTAGGYTLLDGLRLMELQMNKRQAADLTDSVTCLREGAPFYQVL KSLSFHKEAVGICYFAETHGELPASMIQSGELLERKIAQADQLKRVLRYPLFLIFTVA VMFYMLQSIIIPQFSGIYQSMNMETSRSTDMLFAFFQHIDLVIILLVLFTAGIGIYYW LVFKKKSPARQMLICIRIPLVGKLVKLFNSYFFSLQLSSLLKSGLSIYDSLNAFKHQT FLPFYRCEAEQLIERLKAGESIESAICGSLFYETDLSKVISHGQLSGRLDRELFTYSQ FILQRLEHKAQKWTGILQPMIYGFVAAMILLVYLSMLVPMYQMMNQM*" /label="comGB CDS" gene complement(2068335..2069306) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /label="comGB gene" CDS complement(2069359..2070429) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane associated ATPase of the pilin platformfor DNA competence" /protein_id="NP_390353.1" /db_xref="EnsemblGenomes-Gn:BSU24730" /db_xref="EnsemblGenomes-Tr:CAB14404" /db_xref="GOA:P25953" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10483" /db_xref="UniProtKB/Swiss-Prot:P25953" /translation="MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLK KRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEES LVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQY AKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRD AETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDL ACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIR KGIALGYLTTNNYDRWVYHEKD*" /label="comGA CDS" gene complement(2069359..2070429) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /label="comGA gene" promotor_-10 complement(2070447..2070466) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2070463) /Source="Nicolas_upshifts" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2070480..2070487) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2070612..2070840) /Source="Nicolas_S_feature" /locus_tag="new_2560260_2560488_c" /HighExp="Etha, Salt, Sw, Gly, LPhT, B36, Heat, B60, LoTm, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37350499999999998" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S926" downshifts complement(2070653) /Source="Nicolas_upshifts" /id="D1283" /incds=0 /nref=16 /ntot=42 /MaxReadThrough="0.95925" /MaxDrop="5.92871" /score="30.7083619" /energy="-13" /TU="NA" /idTUdmin="U1920" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2070841..2071794) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15856219, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15856219, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="CorA-type divalent ion transporter" /protein_id="NP_390354.1" /db_xref="EnsemblGenomes-Gn:BSU24740" /db_xref="EnsemblGenomes-Tr:CAB14405" /db_xref="GOA:P40948" /db_xref="InterPro:IPR002523" /db_xref="SubtiList:BG11075" /db_xref="UniProtKB/Swiss-Prot:P40948" /translation="MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHV NFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKG KEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRV HLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGE LNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLF SLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL*" /label="yqxL CDS" gene complement(2070841..2071794) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /label="yqxL gene" promotor_-10 complement(2071818..2071837) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2071839) /Source="Nicolas_upshifts" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2071851..2071857) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2071877..2071883 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2071898..2071916 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2071916 /Source="Nicolas_upshifts" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="upshifts" CDS 2071937..2073265 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane associated enzyme" /protein_id="NP_390355.1" /db_xref="EnsemblGenomes-Gn:BSU24750" /db_xref="EnsemblGenomes-Tr:CAB14406" /db_xref="GOA:P54505" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11695" /db_xref="UniProtKB/Swiss-Prot:P54505" /translation="MPSLEKAVVLEFINLLAVAILILLTGFFVAVEFSIVKVRRSKID QLVAKGKKGAKAAKHVITHLDEYLSACQLGITVAALGLGWLGEPTVQTLLRPLFHKAG LNESLTHLLSLVIAFLVVTYLNVVIGELAPKSFAIQKAESITLLFAKPLIWFYKIMFP FIWLLNHSARLITGVFGLKPASEHELAYTEEELRVLLAESYKSGEIRKSELKYMNNIF TFDKRMAKEIMVPRNEMVSLSLDEDSISNLQETVKQTKYTRYPVVREDKDNVIGVINM KEVLFSMLTKDFSIKKHQIEPFVQPVIHVIETIPIYKLLLKMQKERTHMAILIDEYGG TSGLVTVEDIIEEIVGEIRDEFDADEVPHIRELGKDHYLLNAKLLISDVNSLLGTDLS EAEVDTLGGWFLTQNIDAEPESAIEYDGYSFKVKDINSHHILFIEVKKAE*" /label="yqhB CDS" gene 2071937..2073265 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /label="yqhB gene" S_feature 2073266..2074240 /Source="Nicolas_S_feature" /locus_tag="new_2562914_2563888" /HighExp="Sw, Salt, Etha, LPhT, M9-stat, S8, BC, S6, BT, Gly" /AntisenseName="rsbRD" /AntisenseCor="0.58358076577781004" /AntisenseRegPval="-25.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S927" CDS complement(2073318..2074154) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11157946, 15312768, 15583165, 16963570, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157946, 15312768, 15583165, 16963570, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_390356.2" /db_xref="EnsemblGenomes-Gn:BSU24760" /db_xref="EnsemblGenomes-Tr:CAB14407" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR025751" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11694" /db_xref="UniProtKB/Swiss-Prot:P54504" /translation="MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLK DQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEW IHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELS APIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVA YQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIK EC*" /label="rsbRD CDS" gene complement(2073318..2074154) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /label="rsbRD gene" S_feature complement(2074155..2074339) /Source="Nicolas_S_feature" /locus_tag="new_2563803_2563987_c" /HighExp="Etha, LoTm, Salt, Heat, Gly, M9-stat, B60, S8, S0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147982" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S928" tRNA 2074241..2074311 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln (UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Gln1 tRNA" gene 2074241..2074311 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /label="trnSL-Gln1 gene" CDS complement(2074378..2074758) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:18643936, 22812682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18643936, 22812682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of stress" /protein_id="NP_390357.2" /db_xref="EnsemblGenomes-Gn:BSU24770" /db_xref="EnsemblGenomes-Tr:CAB14408" /db_xref="GOA:P54503" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11693" /db_xref="UniProtKB/Swiss-Prot:P54503" /translation="MEQQLTFYSYPSCTSCRKTKHWLKAHQIEFNERHLFRETPTREE LKYILSLTTEGIDEILATRSQTFKNLNLNIEEMTVNEVLELLIEKPKLLRRPILVDNK KLVIGYNPGELLKLSKKKTVHQSA*" /label="mgsR CDS" gene complement(2074378..2074758) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /label="mgsR gene" downshifts complement(2074384) /Source="Nicolas_upshifts" /id="D1284" /incds=0 /nref=9 /ntot=174 /MaxReadThrough="6.12556" /MaxDrop="6.72616" /score="0.164931099" /energy="-19.7" /TU="U1922" /idTUdmin="U1925" /TUdmin=912 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2074787..2074805) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2074806) /Source="Nicolas_upshifts" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2074820..2074826) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2074845..2074850 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-35" promotor_-10 2074866..2074884 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-10" upshifts 2074875 /Source="Nicolas_upshifts" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="upshifts" promotor_-35 2074925..2074932 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-35" upshifts 2074947 /Source="Nicolas_upshifts" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="upshifts" promotor_-10 2074948..2074967 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-10" CDS 2074990..2075235 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390358.1" /db_xref="EnsemblGenomes-Gn:BSU24780" /db_xref="EnsemblGenomes-Tr:CAB14409" /db_xref="GOA:P54502" /db_xref="InterPro:IPR020254" /db_xref="SubtiList:BG11692" /db_xref="UniProtKB/Swiss-Prot:P54502" /translation="MNRMFRVLGFWTGIFAVMFYLGDMKDASLLFFGQTILFVFLSYL NLTERMYIYIFGAYLTIFFAGFTYYSIFIMVPGGGGH*" /label="yqgY CDS" gene 2074990..2075235 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /label="yqgY gene" downshifts 2075132 /Source="Nicolas_upshifts" /id="D1285" /incds=1 /nref=1 /ntot=86 /MaxReadThrough="6.68961" /MaxDrop="2.1025" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=176 /isTUend="FALSE" /label="downshifts" downshifts 2075221 /Source="Nicolas_upshifts" /id="D1286" /incds=0 /nref=98 /ntot=234 /MaxReadThrough="4.03872" /MaxDrop="5.76938" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=265 /isTUend="FALSE" /label="downshifts" S_feature 2075266..2076021 /Source="Nicolas_S_feature" /locus_tag="new_2564914_2565669" /HighExp="M9-stat, T0.30H, T1.30H, LoTm, T1.0H, B60, T2.0H, S5, S4, T2.30H" /AntisenseName="yqgX" /AntisenseCor="-0.68109878166952498" /AntisenseRegPval="-37.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S929" CDS complement(2075275..2075910) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20669241, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-binding hydrolase" /protein_id="NP_390359.1" /db_xref="EnsemblGenomes-Gn:BSU24790" /db_xref="EnsemblGenomes-Tr:CAB14410" /db_xref="GOA:P54501" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11691" /db_xref="UniProtKB/Swiss-Prot:P54501" /translation="MKWRRMPVGPIQANAYFLISDDQCLIFDPGGEGHKINQYIKEKG LTPLAILLTHAHFDHIGALDEVREKWDIPVYLHQNEKNWLADASLNGSGMLRGIEVTA KPADHLIEGDGELNIGPFHLETLFTPGHSPGSVSYYVKDADLVISGDVLFQGGIGRTD LIGGNQETLLTSIHEKLLTLPEHTLVLSGHGPETDVLTEQDQNPFLNGFSL*" /label="yqgX CDS" gene complement(2075275..2075910) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /label="yqgX gene" downshifts complement(2075300) /Source="Nicolas_upshifts" /id="D1287" /incds=0 /nref=154 /ntot=239 /MaxReadThrough="1.42757" /MaxDrop="5.15622" /score="-8.36666809" /energy="-13.7" /TU="NA" /idTUdmin="U1925" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2075932..2075951) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2075949) /Source="Nicolas_upshifts" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2075965..2075972) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2075989..2075996 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2076011..2076030 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2076023 /Source="Nicolas_upshifts" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2076043) /Source="Nicolas_upshifts" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2076045..2076059) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2076067..2076071) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2076067..2076240 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390360.1" /db_xref="EnsemblGenomes-Gn:BSU24800" /db_xref="EnsemblGenomes-Tr:CAB14411" /db_xref="GOA:P54500" /db_xref="InterPro:IPR024490" /db_xref="SubtiList:BG11690" /db_xref="UniProtKB/Swiss-Prot:P54500" /translation="MLLVVIFGLVALFALWGVLRSVRNKNILGFLLAGATLFVFGWFT VMTVINSGYPTAH*" /label="yqgW CDS" gene 2076067..2076240 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /label="yqgW gene" downshifts 2076228 /Source="Nicolas_upshifts" /id="D1288" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="3.92092" /MaxDrop="7.18555" /score="14.1643615" /energy="-12.4" /TU="U1926" /idTUdmin="U1924" /TUdmin=217 /isTUend="FALSE" /label="downshifts" CDS complement(2076272..2076586) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390361.2" /db_xref="EnsemblGenomes-Gn:BSU24810" /db_xref="EnsemblGenomes-Tr:CAB14412" /db_xref="GOA:P54499" /db_xref="InterPro:IPR002767" /db_xref="InterPro:IPR029756" /db_xref="SubtiList:BG11689" /db_xref="UniProtKB/Swiss-Prot:P54499" /translation="MAIADVTIIPIGTETPSVSAYVADVQKILEGYQAEGKIKYQLTP MNTLIEGELSDLFAVIQAIHEAPFQKGLHRVATNIRIDDRRDKKTTLESKIESVNKHL QP*" /label="yqgV CDS" gene complement(2076272..2076586) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /label="yqgV gene" S_feature 2076273..2077340 /Source="Nicolas_S_feature" /locus_tag="new_2565921_2566988" /HighExp="LoTm, M9-stat, C30, Cold, S8, S7, B60, Lbstat, G135, C90" /AntisenseName="yqgV" /AntisenseCor="-0.23995763414552801" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigEF" /TUlongPSig="1, 1" /label="S930" downshifts complement(2076286) /Source="Nicolas_upshifts" /id="D1289" /incds=0 /nref=247 /ntot=265 /MaxReadThrough="2.24429" /MaxDrop="6.85096" /score="0.185625845" /energy="-12.4" /TU="NA" /idTUdmin="U1928" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2076589..2077650) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390362.2" /db_xref="EnsemblGenomes-Gn:BSU24820" /db_xref="EnsemblGenomes-Tr:CAB14413" /db_xref="GOA:P54498" /db_xref="SubtiList:BG11688" /db_xref="UniProtKB/Swiss-Prot:P54498" /translation="MLMRSVCFILLAVLLFSLSACEPSHQQQKQASAAKDEKKDIIPL SAEKADGAEGWLNNSTILYTASNPTKTELFAYRIFTGKAKKLYQTDGQIVDVQINARE QMILLQITHSQKTAVVLLNAEGETLYEKDYETYELEAAWNQYDPYQMMVTEFNENWDF HTYQVNAKKDESFLSPVQVPFIHWTSKNTFDYVKEGRDDKTGPLYTFDTASKTEQKLE DNVLFFDSFHQMSFTVKSASGGKGTYQFKTPQSTSPVTAKWPLQAKYTSLAPMEYDYD EAGGLFYTFKQSGDAYKLAAINVASGETKDLVSLREMEPIQISPNGKYALYGFHFEQI ILLKSHETKQLIIDQKEME*" /label="yqgU CDS" gene complement(2076589..2077650) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /label="yqgU gene" CDS complement(2077712..2078842) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12765833, 24163346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative d,l-endopeptidase" /protein_id="NP_390363.1" /db_xref="EnsemblGenomes-Gn:BSU24830" /db_xref="EnsemblGenomes-Tr:CAB14414" /db_xref="GOA:P54497" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR034274" /db_xref="SubtiList:BG11687" /db_xref="UniProtKB/Swiss-Prot:P54497" /translation="MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCP GYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPF VSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLC CNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFN EWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPP DRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIH HYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE*" /label="yqgT CDS" gene complement(2077712..2078842) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /label="yqgT gene" promotor_-10 complement(2078850..2078868) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2078882) /Source="Nicolas_upshifts" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2078884..2078889) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2078925..2080841) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647, 25666134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647, 25666134; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_390364.2" /db_xref="EnsemblGenomes-Gn:BSU24840" /db_xref="EnsemblGenomes-Tr:CAB14415" /db_xref="GOA:P54496" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG11686" /db_xref="UniProtKB/Swiss-Prot:P54496" /translation="MRKTFFSKISFMLIAILLMWLKTYAVYKTSFHIKIDNLTQEFIL FINPLSFLLLIFGLSLFLKGKNRNRYIIAMSCLVTFVLLANMVFYRFYNDFLTIPVLF QTSNMGDLGSSIGTLLEPTDLLLAVDIAVLIWLHIRQKAFQSDIPSTKNERAAYFLFV ASVYFFNLGLSEAERPQLLTRSFDREMLVKNISLFNFHIYDGVLQSKQSAQRALADSN SLTEIENYVTANAKDANKRLFGAAKGRNVILVSLESTQSFVINEKLNGEEITPFLNDF IKQSYNFNNVYHQTGQGKTSDSEFIVDNSLYPLGRGAVFFTNAGNQYMAAPEILKNSG YYSAVLHANNKSFWNRDLMYDSFGYDSFFDINSYDVTDENSVGWGLKDKEFFEQSSEL MKNLPQPFYSRLITLTNHFPFDLDEEDQLIDEYDSNSQTLNKYFPTVRYQDEALKRFI EKLKEDGLYDNSVIVLYGDHYGISENHNEAMGQFLGKEITPFEEVQLQKVPLVIHIPG ITDKKPQTIETVGGQIDIRPTLMNLLGIDTKDQIQFGNDLLSDEKLDFTVLRDGSFIT DQVVYTDGACYDKETGKPLEETKQCEAFADKAKQELSLSDEIIYGDLLRFYDQKRLDN SSKRKEKQMLDQAS*" /label="ltaSC CDS" gene complement(2078925..2080841) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /label="ltaSC gene" downshifts complement(2078952) /Source="Nicolas_upshifts" /id="D1290" /incds=0 /nref=5 /ntot=142 /MaxReadThrough="4.5611" /MaxDrop="3.8416" /score="15.4764643" /energy="-14.5" /TU="U1930,U1931" /idTUdmin="U1928" /TUdmin="-2667" /isTUend="FALSE" /label="downshifts" promotor_-35 2079957..2079963 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2079976..2081005 /Source="Nicolas_S_feature" /locus_tag="new_2569624_2570653" /HighExp="Etha, Gly, M9-stat, Salt, S8, LPhT, S7, Sw, HiTm, B60" /AntisenseName="yqgS" /AntisenseCor="-0.36996929809172002" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S931" upshifts 2079976 /Source="Nicolas_upshifts" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2079979..2079997 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(2080842..2080908) /Source="Nicolas_S_feature" /locus_tag="new_2570490_2570556_c" /HighExp="T-3.40H, BC, Sw, S5, Lbstat, T-5.40H, S4, ferm, C30, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S932" promotor_-10 complement(2080902..2080921) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2080908) /Source="Nicolas_upshifts" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2080936..2080943) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2080958..2081923) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /EC_number="2.7.1.59" /EC_number="2.7.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose kinase" /protein_id="NP_390365.2" /db_xref="EnsemblGenomes-Gn:BSU24850" /db_xref="EnsemblGenomes-Tr:CAB14416" /db_xref="GOA:P54495" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR004654" /db_xref="SubtiList:BG11685" /db_xref="UniProtKB/Swiss-Prot:P54495" /translation="MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITV TIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETE TGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGG EIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSAR DVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVE KTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC*" /label="glcK CDS" gene complement(2080958..2081923) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /label="glcK gene" CDS complement(2081934..2082149) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /function="9.3: Transcription factors" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15050034, 20057058; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative single strand nucleic acid binding transcription factor" /protein_id="NP_390366.1" /db_xref="EnsemblGenomes-Gn:BSU24860" /db_xref="EnsemblGenomes-Tr:CAB14417" /db_xref="InterPro:IPR009256" /db_xref="InterPro:IPR023164" /db_xref="PDB:2NN4" /db_xref="SubtiList:BG11684" /db_xref="UniProtKB/Swiss-Prot:P54494" /translation="MNTFYDVQQLLKTFGHIVYFGDRELEIEFMLDELKELYMNHMIE KEQWARAAAVLRKELEQTKNGRDFYKG*" /label="yqgQ CDS" gene complement(2081934..2082149) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /label="yqgQ gene" S_feature complement(2082150..2082258) /Source="Nicolas_S_feature" /locus_tag="new_2571798_2571906_c" /HighExp="M0t90, Lbstat, M40t90, M40t45, Lbtran, Mt0, dia5, Diami, M0t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S933" CDS complement(2082259..2083782) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /EC_number="3.4.21.105" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15050034, 16355228, 23518036, 26858402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane endopeptidase" /protein_id="NP_390367.2" /db_xref="EnsemblGenomes-Gn:BSU24870" /db_xref="EnsemblGenomes-Tr:CAB14418" /db_xref="GOA:P54493" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG11683" /db_xref="UniProtKB/Swiss-Prot:P54493" /translation="MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLV RLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKK TFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLK QEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIA QGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIAS FVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNI DNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESA LIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERA VKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES* " /label="glpG CDS" gene complement(2082259..2083782) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /label="glpG gene" promotor_-10 complement(2083800..2083819) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2083813) /Source="Nicolas_upshifts" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2083834..2083841) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2083872..2084045) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390368.1" /db_xref="EnsemblGenomes-Gn:BSU24880" /db_xref="EnsemblGenomes-Tr:CAB14419" /db_xref="SubtiList:BG11682" /db_xref="UniProtKB/Swiss-Prot:P54492" /translation="MKKLLIYAIFAVSAVMFYQNRYRLMNTVLSQPGIRRSFIHLFLR IPFIRNKFIQQAF*" /label="yqgO CDS" gene complement(2083872..2084045) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /label="yqgO gene" downshifts complement(2083899) /Source="Nicolas_upshifts" /id="D1291" /incds=0 /nref=121 /ntot=211 /MaxReadThrough="2.93694" /MaxDrop="5.6047" /score="19.2452946" /energy="-8.9" /TU="NA" /idTUdmin="U1932" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2084061..2084072) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2084073) /Source="Nicolas_upshifts" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2084086..2084092) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2084112..2084675) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /EC_number="6.3.3.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17329806, 20952389, 22773193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-formyltetrahydrofolate cyclo-ligase" /protein_id="NP_390369.1" /db_xref="EnsemblGenomes-Gn:BSU24890" /db_xref="EnsemblGenomes-Tr:CAB14420" /db_xref="GOA:P54491" /db_xref="InterPro:IPR002698" /db_xref="PDB:1YDM" /db_xref="SubtiList:BG11681" /db_xref="UniProtKB/Swiss-Prot:P54491" /translation="MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTI AVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLE PVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQL FAHVPRLPHDIPVHKLITEDRIISCFS*" /label="folN CDS" gene complement(2084112..2084675) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /label="folN gene" S_feature complement(2084676..2084759) /Source="Nicolas_S_feature" /locus_tag="new_2574324_2574407_c" /HighExp="Cold, G180, LBGexp, LBGtran, G135, HPh, LPh, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S934" CDS complement(2084760..2084909) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12904577, 19648245, 22720735, 23002217, 27561249; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_570908.2" /db_xref="EnsemblGenomes-Gn:BSU24900" /db_xref="EnsemblGenomes-Tr:CAE01461" /db_xref="GOA:P56849" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG14180" /db_xref="UniProtKB/Swiss-Prot:P56849" /translation="MRVNITLACTECGERNYISKKNKRNNPDRVEFKKYCPRDKKSTL HRETK*" /label="rpmGA CDS" gene complement(2084760..2084909) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /label="rpmGA gene" downshifts complement(2084806) /Source="Nicolas_upshifts" /id="D1292" /incds=0 /nref=154 /ntot=253 /MaxReadThrough="5.3064" /MaxDrop="4.5881" /score="34.7393253" /energy="-15.3" /TU="U1933" /idTUdmin="U1932" /TUdmin="-907" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2084946..2084965) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2084956) /Source="Nicolas_upshifts" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2084981..2084984) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2084993..2086072) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_390370.2" /db_xref="EnsemblGenomes-Gn:BSU24910" /db_xref="EnsemblGenomes-Tr:CAB14421" /db_xref="GOA:P54490" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11680" /db_xref="UniProtKB/Swiss-Prot:P54490" /translation="MNILMLSPEHPDEPKSGLGVHLNRLISYLNPHINITVFTPSGQL FSYAKFEDYIADANFTMVRHVLSHNKRFDLIHAHDDTTAPAAQYLKQRLGLPLAATIH GLESERKKVCREAPHPYRLMTERLLIESADALIVLSTFMKRSLDKAAHKKITVIPSPA SMEEEKGKIPRSMNRRFLFSYGRFVPEKGLSQLLKVFAILKQRQPDLYLVLAGEGPSL SCYEKLAAAYNLKDRVMFLPFLNRKDIRTLLSHCEMAVFPSSYEPFGLAAQESMEQGV LTVVSQSGGFCDYAVHDKTAIIADFTLVQEAADLLDSFLKDREKARRIKEAGRQQVFK LHHPRLIMSSYLQLYERIFNNSAIH*" /label="yqgM CDS" gene complement(2084993..2086072) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /label="yqgM gene" CDS complement(2086069..2086539) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390371.1" /db_xref="EnsemblGenomes-Gn:BSU24920" /db_xref="EnsemblGenomes-Tr:CAB14422" /db_xref="SubtiList:BG11679" /db_xref="UniProtKB/Swiss-Prot:P54489" /translation="MDKHPFPYNIRHKLSFFRDTFDIIIQNAHTLTVSWEISEETMRL AEAVLFEKTQDMIKELRIVIKRKDIEAVRTKRTTYDKGEWTIRQAAGDAVYRAEYRIV NSMNVSLKLAGTDDIYLDENGIRHINSFQIEEAHTRWEAQFSAYTCYGRGEKER*" /label="yqgL CDS" gene complement(2086069..2086539) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /label="yqgL gene" promotor_-35 2086484..2086492 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2086506..2086514 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2086507..2086680 /Source="Nicolas_S_feature" /locus_tag="new_2576155_2576328" /HighExp="M9-stat, T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, Lbstat, T3.30H, B60" /AntisenseName="yqgL" /AntisenseCor="0.210779859401483" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S935" upshifts 2086508 /Source="Nicolas_upshifts" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2086575..2086594) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2086587) /Source="Nicolas_upshifts" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2086606..2086613) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2086652..2086656 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2086672..2086691 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2086682 /Source="Nicolas_upshifts" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" CDS 2086719..2087072 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390372.1" /db_xref="EnsemblGenomes-Gn:BSU24930" /db_xref="EnsemblGenomes-Tr:CAB14423" /db_xref="GOA:O32022" /db_xref="SubtiList:BG13770" /db_xref="UniProtKB/Swiss-Prot:O32022" /translation="MEIAIIALFIVSIALIAFSYSQRDPMKDVEQELETLQLSAMQEI YKLKKKMTVLEEELLETNLVIRKSKQNDINQKIAKQILSKYNNGMSAEAIAKAEHVSV EDVNTIIKDNEKVLV*" /label="yqzD CDS" gene 2086719..2087072 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /label="yqzD gene" CDS 2087069..2087533 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390373.2" /db_xref="EnsemblGenomes-Gn:BSU24940" /db_xref="EnsemblGenomes-Tr:CAB14424" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13769" /db_xref="UniProtKB/Swiss-Prot:O32023" /translation="MTKRGIQAFAGGIILATAVLAAVFYLTDEDQAAAVKDNKTVTEQ DVNNYLDSKKLVSVNRDEYQKLLDSKEKSLNNDSGSDTKSDKVKTYKLTIKDGMSTAD VSAILEKEGIISSAQDFNDYVIDAGYHKEIRAGEFKVKSDMSFKKIVKTLTR*" /label="yqzC CDS" gene 2087069..2087533 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /label="yqzC gene" downshifts 2087519 /Source="Nicolas_upshifts" /id="D1293" /incds=0 /nref=216 /ntot=264 /MaxReadThrough="0.9847" /MaxDrop="6.07831" /score="21.2108939" /energy="-8.8" /TU="NA" /idTUdmin="U1934" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2087562..2088344) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390374.1" /db_xref="EnsemblGenomes-Gn:BSU24950" /db_xref="EnsemblGenomes-Tr:CAB14425" /db_xref="GOA:P46342" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11379" /db_xref="UniProtKB/Swiss-Prot:P46342" /translation="MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAI IGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQK GNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGG QQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQA ARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG*" /label="pstBB CDS" gene complement(2087562..2088344) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /label="pstBB gene" downshifts complement(2087573) /Source="Nicolas_upshifts" /id="D1294" /incds=0 /nref=20 /ntot=46 /MaxReadThrough="2.29658" /MaxDrop="6.53816" /score="26.1659198" /energy="-8.8" /TU="NA" /idTUdmin="U1937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2088355..2089164) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390375.1" /db_xref="EnsemblGenomes-Gn:BSU24960" /db_xref="EnsemblGenomes-Tr:CAB14426" /db_xref="GOA:P46341" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11378" /db_xref="UniProtKB/Swiss-Prot:P46341" /translation="MSEQMVKEKPERAVIVPKQNHVLEVKDLSIYYGNKQAVHHVNMD IEKNAVTALIGPSGCGKSTFLRNINRMNDLIPSARAEGEILYEGLNILGGNINVVSLR REIGMVFQKPNPFPKSIYANITHALKYAGERNKAVLDEIVEESLTKAALWDEVKDRLH SSALSLSGGQQQRLCIARTLAMKPAVLLLDEPASALDPISNAKIEELITGLKREYSII IVTHNMQQALRVSDRTAFFLNGELVEYGQTEQIFTSPKKQKTEDYINGKFG*" /label="pstBA CDS" gene complement(2088355..2089164) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /label="pstBA gene" CDS complement(2089185..2090069) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390376.2" /db_xref="EnsemblGenomes-Gn:BSU24970" /db_xref="EnsemblGenomes-Tr:CAB14427" /db_xref="GOA:P46340" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005672" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11377" /db_xref="UniProtKB/Swiss-Prot:P46340" /translation="MNRKITDKLATGMFGLCAAIIAAILVGLFSYIIINGVSQLSFQF ITTKSSAIAAGGGIRDQLFNSFYILFITMLITIPLGVGGGVFMAEYAPNNKVTDFIRT CIEVLSSLPSIVIGMFGLLMFVNLTGWGYTIIGGALALTVFNLPVMVRVTEDAIRSVP KDLKEASLALGVSRWHTVKTVLIPSAIPSIITGAILASGRVFGEAAALLFTAGLTTPR LNFTEWNPFSETSPLNIFRPAETLAVHIWNVNTQGMIPDAEAIANGGSAVLVISVLVF NLAARWLGTMIYKKLTAN*" /label="pstA CDS" gene complement(2089185..2090069) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /label="pstA gene" CDS complement(2090069..2090998) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390377.2" /db_xref="EnsemblGenomes-Gn:BSU24980" /db_xref="EnsemblGenomes-Tr:CAB14428" /db_xref="GOA:P46339" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011864" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11376" /db_xref="UniProtKB/Swiss-Prot:P46339" /translation="MINNRENMSVSERLISSRQNRQLDEVRGRMIVTACALIMIAASV AITIFLGVKGLQSFLVNGVSPIEFLTSLNWNPTDSDPKYGVLPFIFGSFAVTILSALI AAPLGIAGAIFMTEIAPNWGKKVLQPVIELLVGIPSVVYGFIGLTVLVPFIAQFKSSG TGHSLLAGTIVLSVMILPTITSISADAMASLPKSLREGSYALGATRWQTIRKVLVPAA FPTLMTAVVLGMARAFGEALAVQMVIGNTRVLPESPFDTAGTLTTIITLNMGHTTYGS VENNTLWSMGLVLLVMSFLFILLIRYLSSRRKV*" /label="pstC CDS" gene complement(2090069..2090998) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /label="pstC gene" CDS complement(2091067..2091969) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 9593301, 10913081, 15289558, 21461370, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 9593301, 10913081, 15289558, 21461370, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (phosphate binding lipoprotein)" /protein_id="NP_390378.1" /db_xref="EnsemblGenomes-Gn:BSU24990" /db_xref="EnsemblGenomes-Tr:CAB14429" /db_xref="GOA:P46338" /db_xref="InterPro:IPR011862" /db_xref="InterPro:IPR024370" /db_xref="SubtiList:BG11375" /db_xref="UniProtKB/Swiss-Prot:P46338" /translation="MKKNKLVLMLLMAAFMMIAAACGNAGESKKSNSDSAKGEEKASG SLTISGSSAMQPLVLAAAEKFMEENPDADIQVQAGGSGTGLSQVSEGAVQIGNSDVFA EEKEGIDAKALVDHQVAVVGMAAAVNPDAGVKDISKDELKKIFTGKIKNWKELGGKDQ KITLVNRPDSSGTRATFVKYALDGAEPAEGITEDSSNTVKKIIADTPGAIGYLAFSYL TDDKVTALSIDGVKPEAKNVATGEYPIWAYQHSYTKGEATGLAKEFLDYLKSEDIQKS IVTDQGYIPVTDMKVTRDANGKQS*" /label="pstS CDS" gene complement(2091067..2091969) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /label="pstS gene" upshifts complement(2092024) /Source="Nicolas_upshifts" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2092032..2092048) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2092059..2092061) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-35" Polymorphism join(2092078,2092080) /Source="geneious" /ID="SNP_BsDelta6_2581727_2581726" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)6 -> (T)7" /Codon_Change /Coverage=117 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=114 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2092124..2094274) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /EC_number="3.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9139922, 9851991, 12896990, 17307860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139922, 9851991, 12896990, 17307860; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transpeptidase (penicillin-binding protein 2A)" /protein_id="NP_390379.1" /db_xref="EnsemblGenomes-Gn:BSU25000" /db_xref="EnsemblGenomes-Tr:CAB14430" /db_xref="GOA:P54488" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11678" /db_xref="UniProtKB/Swiss-Prot:P54488" /translation="MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQ IVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQR LKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLY QLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLD ELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSY LEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIE KKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSS YAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEK SSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGY KGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIG AVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSF YDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMD KYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN*" /label="pbpA CDS" gene complement(2092124..2094274) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /label="pbpA gene" downshifts complement(2092134) /Source="Nicolas_upshifts" /id="D1295" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="1.22121" /MaxDrop="8.82988" /score="31.2726004" /energy="-10" /TU="U1940" /idTUdmin="U1938" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2092868..2092886) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2092876) /Source="Nicolas_upshifts" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2092902..2092908) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2093563..2093582) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2093580) /Source="Nicolas_upshifts" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2093596..2093605) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2094324..2094343) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2094329) /Source="Nicolas_upshifts" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2094359..2094363) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2094388..2095680) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390380.2" /db_xref="EnsemblGenomes-Gn:BSU25010" /db_xref="EnsemblGenomes-Tr:CAB14431" /db_xref="GOA:P54487" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11677" /db_xref="UniProtKB/Swiss-Prot:P54487" /translation="MSKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWK QSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGE TAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIV AGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMN WRRITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLI KKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVI GRARHARKARIEYIVLREMFLNAGRIVSILCFLLIVALLKEDVGIPLSLAILGIGHPL IYYFVKDIRFKEKEGENETMEEDGQKRVTEPTLLKGER*" /label="yqgE CDS" gene complement(2094388..2095680) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /label="yqgE gene" promotor_-10 complement(2095703..2095714) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2095714) /Source="Nicolas_upshifts" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2095728..2095734) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2095787..2096395) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /EC_number="1.15.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Mn[2+]-dependent)" /protein_id="NP_390381.3" /db_xref="EnsemblGenomes-Gn:BSU25020" /db_xref="EnsemblGenomes-Tr:CAB14432" /db_xref="GOA:P54375" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="PDB:2RCV" /db_xref="SubtiList:BG11676" /db_xref="UniProtKB/Swiss-Prot:P54375" /translation="MAYELPELPYAYDALEPHIDKETMTIHHTKHHNTYVTNLNKAVE GNTALANKSVEELVADLDSVPENIRTAVRNNGGGHANHKLFWTLLSPNGGGEPTGALA EEINSVFGSFDKFKEQFAAAAAGRFGSGWAWLVVNNGKLEITSTPNQDSPLSEGKTPI LGLDVWEHAYYLNYQNRRPDYISAFWNVVNWDEVARLYSEAK*" /label="sodA CDS" gene complement(2095787..2096395) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /label="sodA gene" downshifts complement(2095802) /Source="Nicolas_upshifts" /id="D1296" /incds=0 /nref=265 /ntot=268 /MaxReadThrough="4.329" /MaxDrop="9.16338" /score="3.26408916" /energy="-8.1" /TU="U1943" /idTUdmin="U1942" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2096447..2096466) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2096458) /Source="Nicolas_upshifts" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2096460..2096528) /Source="Nicolas_S_feature" /locus_tag="new_2586107_2586175_c" /HighExp="Etha, Salt, Heat, LPhT, Gly, Sw, S4, LoTm, M9-stat, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigB" /TUlongPSig="0.999" /label="S936" promotor_-35 complement(2096481..2096488) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2096519..2096537) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2096528) /Source="Nicolas_upshifts" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2096552..2096558) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2096574..2097056) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390382.1" /db_xref="EnsemblGenomes-Gn:BSU25030" /db_xref="EnsemblGenomes-Tr:CAB14433" /db_xref="GOA:P54486" /db_xref="InterPro:IPR007403" /db_xref="SubtiList:BG11675" /db_xref="UniProtKB/Swiss-Prot:P54486" /translation="MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSF SPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAG IILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL *" /label="yqgC CDS" gene complement(2096574..2097056) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /label="yqgC gene" S_feature complement(2097057..2097349) /Source="Nicolas_S_feature" /locus_tag="new_2586704_2586996_c" /HighExp="Etha, Gly, Salt, aero, S0, LoTm, HiTm, LPh, nit, ferm" /AntisenseName="yqgB" /AntisenseCor="9.8584854910492598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S937" promotor_-35 2097099..2097105 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2097120..2097139 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2097133 /Source="Nicolas_upshifts" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="upshifts" CDS 2097166..2097933 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15294815; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390383.2" /db_xref="EnsemblGenomes-Gn:BSU25040" /db_xref="EnsemblGenomes-Tr:CAB14434" /db_xref="GOA:P54485" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG11674" /db_xref="UniProtKB/Swiss-Prot:P54485" /translation="MNVFQLFIKSTYSPRDIAKTRFQGIGKAILYVFLLSVLFAIPTA YYVSTGTVKSMNGFKTVLNKDFPDFTISNGKLQTDEKKATESQANGFVIVFDPTDSYG TEQIEAKQNAIGILQNKFVLAIDGQAQEMSYSMMPSELQKKDVIAGLNQNKAMIVTVL SALIFLVTAAGKFIEVSFLALIGLIIKNSQKKHLSYHQLWKLSAYSITLSTVFFTIMR ALEATVPSEFLLNWFVNFVILFLVLKEIPSKKVINKS*" /label="yqgB CDS" gene 2097166..2097933 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /label="yqgB gene" promotor_-10 complement(2097347..2097365) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-10" upshifts complement(2097349) /Source="Nicolas_upshifts" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="upshifts" S_feature complement(2097351..2098287) /Source="Nicolas_S_feature" /locus_tag="new_2586998_2587934_c" /HighExp="S0, S1, aero, M0t45, HPh, Lbtran, LPh, GM 120, nit, M/G" /AntisenseName="yqgB" /AntisenseCor="0.31978785018705103" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S938" promotor_-35 complement(2097379..2097385) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-35" S_feature 2097934..2098364 /Source="Nicolas_S_feature" /locus_tag="new_2587581_2588011" /HighExp="C30, HiOs, UNK1, Gly, Fru, S8, Salt, MG 5, S7, MG 25" /AntisenseName="yqgA" /AntisenseCor="0.170248276038857" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.731" /TUlongSig="NA" /TUlongPSig="NA" /label="S939" downshifts 2098321 /Source="Nicolas_upshifts" /id="D1297" /incds=0 /nref=5 /ntot=131 /MaxReadThrough="3.89102" /MaxDrop="3.29021" /score="30.8580926" /energy="-13.8" /TU="U1944" /idTUdmin="U1944" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(2098332) /Source="Nicolas_upshifts" /id="D1298" /incds=0 /nref=15 /ntot=207 /MaxReadThrough="6.7306" /MaxDrop="3.9194" /score="7.48192829" /energy="-14.3" /TU="U1947" /idTUdmin="U1945" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" CDS complement(2098349..2098777) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /experiment="publication(s) with functional evidences, PMID:25130749, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25130749, 27797724; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="cell wall protein" /protein_id="NP_390384.2" /db_xref="EnsemblGenomes-Gn:BSU25050" /db_xref="EnsemblGenomes-Tr:CAB14435" /db_xref="GOA:P54484" /db_xref="SubtiList:BG11673" /db_xref="UniProtKB/Swiss-Prot:P54484" /translation="MKQGKFSVFLILLLMLTLVVAPKEKAEAASSGWQPVSGISGCKI RVITDAYTYTKSATSIDAYAETNGKCGKLNYKSFGVSIVEGGDIGPQYSGYFSSRTPT KKFYFSKLPKPTGTPWAVGLSVYKGKAKGAAFVYINPQKR*" /label="yqgA CDS" gene complement(2098349..2098777) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /label="yqgA gene" promotor_-35 2098773..2098777 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-35" promotor_-10 2098787..2098801 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-10" upshifts 2098796 /Source="Nicolas_upshifts" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="upshifts" promotor_-10 complement(2098800..2098819) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-10" upshifts complement(2098823) /Source="Nicolas_upshifts" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="upshifts" promotor_-35 complement(2098834..2098841) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-35" promotor_-35 2098992..2098997 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2099013..2099031 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2099025 /Source="Nicolas_upshifts" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2099054..2099353 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15294815; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390385.1" /db_xref="EnsemblGenomes-Gn:BSU25060" /db_xref="EnsemblGenomes-Tr:CAB14436" /db_xref="GOA:P54483" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR020506" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11672" /db_xref="UniProtKB/Swiss-Prot:P54483" /translation="MKRLTLVCSIVFILFILFYDLKIGTIPIQDLPVYEASAKTAVQE PAYKTVKVKPGDTVMSIVGSAGSPDDIVKDFEALNPNVKANAIQAGTAYKFPVYP*" /label="yqfZ CDS" gene 2099054..2099353 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /label="yqfZ gene" promotor_-35 2099366..2099373 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2099388..2099407 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2099399..2099475 /Source="Nicolas_S_feature" /locus_tag="new_2589046_2589122" /HighExp="Diami, dia5, dia15, H2O2, Etha, Salt, LBGexp, Oxctl, Paraq, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="Sig-" /TUlongPSig=0 /label="S940" upshifts 2099399 /Source="Nicolas_upshifts" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2099476..2100609 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /EC_number="1.17.7.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12571359, 16268586, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)" /protein_id="NP_390386.1" /db_xref="EnsemblGenomes-Gn:BSU25070" /db_xref="EnsemblGenomes-Tr:CAB14437" /db_xref="GOA:P54482" /db_xref="InterPro:IPR004588" /db_xref="InterPro:IPR011005" /db_xref="InterPro:IPR016425" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11671" /db_xref="UniProtKB/Swiss-Prot:P54482" /translation="MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEAT VAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGA DKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVES ALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTV KSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRI EIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGK IVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA*" /label="ispG CDS" gene 2099476..2100609 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /label="ispG gene" downshifts 2100590 /Source="Nicolas_upshifts" /id="D1299" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.62035" /MaxDrop="8.92434" /score="30.8580926" /energy="-13.8" /TU="NA" /idTUdmin="U1948" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(2100635..2101024) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function expressed in germinating spores" /protein_id="NP_390387.1" /db_xref="EnsemblGenomes-Gn:BSU25080" /db_xref="EnsemblGenomes-Tr:CAB14438" /db_xref="GOA:P54481" /db_xref="SubtiList:BG11670" /db_xref="UniProtKB/Swiss-Prot:P54481" /translation="MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEP YRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRR GAQGLGAWAMGIGVVSLVLGIFIIPFF*" /label="yqfX CDS" gene complement(2100635..2101024) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /label="yqfX gene" downshifts complement(2100661) /Source="Nicolas_upshifts" /id="D1300" /incds=0 /nref=10 /ntot=62 /MaxReadThrough="1.85077" /MaxDrop="8.74353" /score="28.1764525" /energy="-13.8" /TU="NA" /idTUdmin="U1950" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2101055..2101066) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2101059) /Source="Nicolas_upshifts" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2101080..2101086) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2101099..2101106 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2101117..2101136 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2101118 /Source="Nicolas_upshifts" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="upshifts" CDS 2101157..2101738 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotidase" /protein_id="NP_390388.1" /db_xref="EnsemblGenomes-Gn:BSU25090" /db_xref="EnsemblGenomes-Tr:CAB14439" /db_xref="GOA:P54480" /db_xref="InterPro:IPR009206" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11669" /db_xref="UniProtKB/Swiss-Prot:P54480" /translation="MLRLGIDIDGTITAQDTFVPYLNRSFNLSISLNDMTDYDLTKLL NITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKEEHKLIYITARRTHLTDITYEW FDRQNIHYDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAKEAGIPVILFNSPYN QLPIDSNIIRVNNWLEAVQWMNNNKHHLIRVNN*" /label="yqfW CDS" gene 2101157..2101738 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /label="yqfW gene" downshifts 2101736 /Source="Nicolas_upshifts" /id="D1301" /incds=0 /nref=34 /ntot=240 /MaxReadThrough="4.07255" /MaxDrop="4.44714" /score="-2.90660182" /energy="-8" /TU="U1951" /idTUdmin="U1951" /TUdmin="-611" /isTUend="FALSE" /label="downshifts" S_feature 2101781..2102389 /Source="Nicolas_S_feature" /locus_tag="new_2591428_2592036" /HighExp="LoTm, S8, Cold, S7, S5, Sw, BC, S6, HiOs, B60" /AntisenseName="zur" /AntisenseCor="-0.265512398914523" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S941" CDS complement(2101781..2102218) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Zn[2+]-binding Fur family)" /protein_id="NP_390389.2" /db_xref="EnsemblGenomes-Gn:BSU25100" /db_xref="EnsemblGenomes-Tr:CAB14440" /db_xref="GOA:P54479" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11668" /db_xref="UniProtKB/Swiss-Prot:P54479" /translation="MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSAL NDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTK EIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA*" /label="zur CDS" gene complement(2101781..2102218) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /label="zur gene" downshifts complement(2101785) /Source="Nicolas_upshifts" /id="D1302" /incds=0 /nref=181 /ntot=243 /MaxReadThrough="2.37371" /MaxDrop="6.74703" /score="16.4418277" /energy="-11.9" /TU="U1956" /idTUdmin="U1952" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2102219..2102313) /Source="Nicolas_S_feature" /locus_tag="new_2591866_2591960_c" /HighExp="LPhT, G180, Cold, LBGstat, H2O2, Oxctl, G135, G150, HPh, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S942" promotor_-10 complement(2102309..2102328) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2102313) /Source="Nicolas_upshifts" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2102343..2102350) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2102356..2103237) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390390.2" /db_xref="EnsemblGenomes-Gn:BSU25110" /db_xref="EnsemblGenomes-Tr:CAB14441" /db_xref="GOA:P54478" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11667" /db_xref="UniProtKB/Swiss-Prot:P54478" /translation="MTPTKQHKKETFTHFIFRVFMILVGAASAAVSIELFLIPNDFID GGIIGVSLILDHLFMSNPFLNFAFFVVILNIPFMIFGYKYIGKTFLVSTFIGIVGLAV IESSLHHVEAITTQPILATVFGGLLLGFGVGLVIRNGGSMDGTEILGILLTKKLPFSV GEFVMFINVFIFIWAVFVFGPEQAMYSFMTYYIAMKTIDAVIQGLDETKAVIIVSEQY DEISDAILHRLGRGTTKLKGKGGYTDEEKDVIYAVVTRLEVTKLKSIVFEVDQNAFIT IMNTHETRGGKFKNAIH*" /label="yqfU CDS" gene complement(2102356..2103237) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /label="yqfU gene" promotor_-35 2103233..2103238 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2103254..2103272 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2103270 /Source="Nicolas_upshifts" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2103275..2103294) /Source="Nicolas_upshift_promotors" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2103281) /Source="Nicolas_upshifts" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2103283..2103610) /Source="Nicolas_S_feature" /locus_tag="new_2592930_2593257_c" /HighExp="Cold, T-4.40H, T-5.40H, Salt, GM-0.1, BMM, UNK1, MG 25, GM-0.2, SMM" /AntisenseName="yqfT" /AntisenseCor="-0.62379514374156597" /AntisenseRegPval="-29.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S943" promotor_-35 2103299..2103308 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2103315 /Source="Nicolas_upshifts" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2103321..2103340 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2103353..2103607 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390391.1" /db_xref="EnsemblGenomes-Gn:BSU25120" /db_xref="EnsemblGenomes-Tr:CAB14442" /db_xref="InterPro:IPR020277" /db_xref="SubtiList:BG11666" /db_xref="UniProtKB/Swiss-Prot:P54477" /translation="MILFQRIILQRLNQATADDLLKYSKQYGISLTRSQAVEVANLLY GKNVNIFNESERMRLLKQVETITSKETAQTVNELFKQFTS*" /label="yqfT CDS" gene 2103353..2103607 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /label="yqfT gene" downshifts 2103594 /Source="Nicolas_upshifts" /id="D1303" /incds=0 /nref=12 /ntot=72 /MaxReadThrough="3.97414" /MaxDrop="7.03976" /score="24.5413663" /energy="-9.8" /TU="U1953" /idTUdmin="U1955" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2103634..2104527) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /EC_number="3.1.21.2" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type IV apurinic/apyrimidinic endonuclease" /protein_id="NP_390392.1" /db_xref="EnsemblGenomes-Gn:BSU25130" /db_xref="EnsemblGenomes-Tr:CAB14443" /db_xref="GOA:P54476" /db_xref="InterPro:IPR001719" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR018246" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11665" /db_xref="UniProtKB/Swiss-Prot:P54476" /translation="MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRK KIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAI GAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEE LAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDS KNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRF EIEMLKEKQFDDTLLEKILQQ*" /label="nfo CDS" gene complement(2103634..2104527) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /label="nfo gene" S_feature 2103639..2104440 /Source="Nicolas_S_feature" /locus_tag="new_2593286_2594087" /HighExp="S6, S7, C30, S8, S5, G135, C90, Gly, LoTm, Sw" /AntisenseName="nfo" /AntisenseCor="-0.36683479556464399" /AntisenseRegPval="-9.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S944" downshifts complement(2103655) /Source="Nicolas_upshifts" /id="D1304" /incds=0 /nref=46 /ntot=187 /MaxReadThrough="4.82641" /MaxDrop="6.05328" /score="16.7756411" /energy="-9.8" /TU="U1956" /idTUdmin="U1952" /TUdmin="-1870" /isTUend="FALSE" /label="downshifts" CDS complement(2104537..2105853) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 16352840, 18203828, 20572937, 23175651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16352840, 18203828, 20572937, 23175651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_390393.1" /db_xref="EnsemblGenomes-Gn:BSU25140" /db_xref="EnsemblGenomes-Tr:CAB14444" /db_xref="GOA:P54475" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030881" /db_xref="SubtiList:BG11664" /db_xref="UniProtKB/Swiss-Prot:P54475" /translation="MKETKFELYELKPFIIDAVHRLGFYEPTDIQKRLIPAVLKKESV IGQSQTGTGKTHAYLLPLLNKIDPAKDVVQVVITAPTRELANQIYQEALKITQGEEGS QIRSKCFIGGTDKQKSIDKLKIQPHLVVGTPGRIADLIKEQALSVHKAESLVIDEADL MLDMGFLADVDYIGSRMPEDLQMLVFSATIPEKLKPFLKKYMENPKYAHVEPKQVTAA KIEHILIPSKHRDKDKLLFDIMSHLNPYLGIVFANTKNTADHIAQYLTGKGMKIGLLH GGLTPRERKKVMKQINDLEFTYIIATDLAARGIDIKGVSHVINYELPDDLDFYVHRVG RTARAGSSGQAMTIYELTDEDALVRLEKMGIEFEYLELEKGEWKKGDDRQRRKKRKKT PNEADEIAHRLVKKPKKVKPGYKKKMSYEMEKIKKKQRRNQSKKRK*" /label="cshB CDS" gene complement(2104537..2105853) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /label="cshB gene" promotor_-10 complement(2105889..2105908) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2105900) /Source="Nicolas_upshifts" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2105924..2105928) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2105957..2105966 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2105978 /Source="Nicolas_upshifts" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2105980..2105999 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2106022..2106765 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390394.1" /db_xref="EnsemblGenomes-Gn:BSU25150" /db_xref="EnsemblGenomes-Tr:CAB14445" /db_xref="InterPro:IPR025571" /db_xref="SubtiList:BG11663" /db_xref="UniProtKB/Swiss-Prot:P54474" /translation="MFSPQQPMRNYPQPGPPRPMPNQRMMGRRPPNMRGPSFGAQQQG FQQAGQFLPQANAGARNGAGAGGGLKGMLSRFLPGGGGAGSAGVPGIPGAGAAASGGA GLQGIQNIANPASLSSMLGNVQKVLGMAQQVTPMIQQYGPLVRNLPAMMKLYSQLSKS DDTETEANEESEKQSVSEESSEKEKETETKTSDGNKKSKPKSSSLPKKSKTTDNKEQE LKTSAPKKKEAASPAPKRTSGSSKPRLYI*" /label="yqfQ CDS" gene 2106022..2106765 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /label="yqfQ gene" downshifts 2106747 /Source="Nicolas_upshifts" /id="D1305" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="5.46594" /MaxDrop="3.2445" /score="4.32537428" /energy="-6.8" /TU="U1957" /idTUdmin="U1957" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" promotor_-35 2106769..2106776 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2106790..2106809 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2106792..2106887 /Source="Nicolas_S_feature" /locus_tag="new_2596439_2596534" /HighExp="S8, S7, S6, Cold, H2O2, Salt, dia15, G180, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S945" upshifts 2106792 /Source="Nicolas_upshifts" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="upshifts" CDS 2106888..2107832 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /EC_number="1.17.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12706830, 15381396, 15469281, 17458547, 27169371; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase" /protein_id="NP_390395.2" /db_xref="EnsemblGenomes-Gn:BSU25160" /db_xref="EnsemblGenomes-Tr:CAB14446" /db_xref="GOA:P54473" /db_xref="InterPro:IPR003451" /db_xref="SubtiList:BG11662" /db_xref="UniProtKB/Swiss-Prot:P54473" /translation="MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHN KHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDAT CPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVGVAPEIVHLVETEEDVKNLDIQ SEKLIVTNQTTMSQWDVHDIMELVKEKYPHVEYHQEICLATQVRQEAVSEQAKKADLT IVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPI TKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN*" /label="ispH CDS" gene 2106888..2107832 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /label="ispH gene" downshifts 2107803 /Source="Nicolas_upshifts" /id="D1306" /incds=0 /nref=106 /ntot=243 /MaxReadThrough="4.04288" /MaxDrop="5.66904" /score="29.529951" /energy="-12.2" /TU="U1958" /idTUdmin="U1957" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2107855..2108976) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17187687, 17586767; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative GTP cyclohydrolase" /protein_id="NP_390396.1" /db_xref="EnsemblGenomes-Gn:BSU25170" /db_xref="EnsemblGenomes-Tr:CAB14447" /db_xref="GOA:P54472" /db_xref="InterPro:IPR002678" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017221" /db_xref="InterPro:IPR036069" /db_xref="SubtiList:BG11661" /db_xref="UniProtKB/Swiss-Prot:P54472" /translation="MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVM VTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAA HTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAG AGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVIN AMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMV GDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHY AEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL*" /label="yqfO CDS" gene complement(2107855..2108976) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /label="yqfO gene" downshifts complement(2107880) /Source="Nicolas_upshifts" /id="D1307" /incds=0 /nref=63 /ntot=224 /MaxReadThrough="3.241" /MaxDrop="4.76436" /score="27.9821938" /energy="-12.2" /TU="NA" /idTUdmin="U1959" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2108969..2109619) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /EC_number="2.1.1.217" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:18420655, 27098549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18420655, 27098549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (adenine(22)-N(1))-methyltransferase" /protein_id="NP_390397.1" /db_xref="EnsemblGenomes-Gn:BSU25180" /db_xref="EnsemblGenomes-Tr:CAB14448" /db_xref="GOA:P54471" /db_xref="InterPro:IPR006901" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11660" /db_xref="UniProtKB/Swiss-Prot:P54471" /translation="MADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKS GLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNI HAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFL AKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG*" /label="trmK CDS" gene complement(2108969..2109619) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /label="trmK gene" S_feature complement(2109620..2109728) /Source="Nicolas_S_feature" /locus_tag="new_2599267_2599375_c" /HighExp="LBGexp, LBGtran, dia15, dia0, Lbexp, G150, G180, LBGstat, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S946" promotor_-10 complement(2109716..2109735) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2109728) /Source="Nicolas_upshifts" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2109730..2109843) /Source="Nicolas_S_feature" /locus_tag="new_2599377_2599490_c" /HighExp="Lbstat, M0t90, M9-stat, S2, T1.0H, T1.30H, T2.30H, T3.0H, S7, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S947" promotor_-35 complement(2109751..2109755) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2109876..2110238) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10024472, 10473570, 11361075, 15995641, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024472, 10473570, 11361075, 15995641, 19222757; Product type c: carrier" /codon_start=1 /transl_table=11 /product="cytochrome c550" /protein_id="NP_390398.1" /db_xref="EnsemblGenomes-Gn:BSU25190" /db_xref="EnsemblGenomes-Tr:CAB14449" /db_xref="GOA:P24469" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10315" /db_xref="UniProtKB/Swiss-Prot:P24469" /translation="MKWNPLIPFLLIAVLGIGLTFFLSVKGLDDSREIASGGESKSAE KKDANASPEEIYKANCIACHGENYEGVSGPSLKGVGDKKDVAEIKTKIEKGGNGMPSG LVPADKLDDMAEWVSKIK*" /label="cccA CDS" gene complement(2109876..2110238) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /label="cccA gene" downshifts complement(2109888) /Source="Nicolas_upshifts" /id="D1308" /incds=0 /nref=3 /ntot=88 /MaxReadThrough="4.32389" /MaxDrop="3.4795" /score="-4.13120914" /energy="-7.6" /TU="U1961,U1962" /idTUdmin="U1968" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-35 2110234..2110238 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2110246..2110260 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2110267 /Source="Nicolas_upshifts" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2110275..2110294) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2110277) /Source="Nicolas_upshifts" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2110279..2110400) /Source="Nicolas_S_feature" /locus_tag="new_2599926_2600047_c" /HighExp="Lbstat, T3.0H, T1.30H, M9-stat, T2.30H, T1.0H, T2.0H, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S948" promotor_-35 complement(2110306..2110313) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2110389..2110408) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2110397..2110416 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2110400) /Source="Nicolas_upshifts" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2110402..2110541) /Source="Nicolas_S_feature" /locus_tag="new_2600049_2600188_c" /HighExp="Lbstat, S8, S1, S7, G/S, BT, Mal, Gly, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S949" S_feature 2110403..2110507 /Source="Nicolas_S_feature" /locus_tag="new_2600050_2600154" /HighExp="T2.30H, M9-stat, T3.0H, T1.30H, T2.0H, T1.0H, T3.30H, T4.0H, M0t90, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S950" upshifts 2110403 /Source="Nicolas_upshifts" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2110422..2110428) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2110471..2110478 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2110492..2110511 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2110509..2112658 /Source="Nicolas_S_feature" /locus_tag="new_2600156_2602305" /HighExp="S2, T4.0H, T5.0H, Lbstat, M9-stat, T3.30H, S8, T3.0H, C30, T2.0H" /AntisenseName="sigA" /AntisenseCor="-0.16938350693676901" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S951" upshifts 2110509 /Source="Nicolas_upshifts" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2110567..2111682) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12455702, 12682299, 14527287, 15060039, 15670950, 28648455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12455702, 12682299, 14527287, 15060039, 15670950, 28648455; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase major sigma-43 factor (sigma-A)" /protein_id="NP_390399.2" /db_xref="EnsemblGenomes-Gn:BSU25200" /db_xref="EnsemblGenomes-Tr:CAB14450" /db_xref="GOA:P06224" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007127" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009042" /db_xref="InterPro:IPR012760" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR028630" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10314" /db_xref="UniProtKB/Swiss-Prot:P06224" /translation="MADKQTHETELTFDQVKEQLTESGKKRGVLTYEEIAERMSSFEI ESDQMDEYYEFLGEQGVELISENEETEDPNIQQLAKAEEEFDLNDLSVPPGVKINDPV RMYLKEIGRVNLLSAKEEIAYAQKIEEGDEESKRRLAEANLRLVVSIAKRYVGRGMLF LDLIQEGNMGLMKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVET INKLIRVQRQLLQDLGREPTPEEIAEDMDLTPEKVREILKIAQEPVSLETPIGEEDDS HLGDFIEDQEATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEE VGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE*" /label="sigA CDS" gene complement(2110567..2111682) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /label="sigA gene" downshifts complement(2110586) /Source="Nicolas_upshifts" /id="D1309" /incds=0 /nref=118 /ntot=198 /MaxReadThrough="4.93947" /MaxDrop="6.16048" /score="4.75833607" /energy="-11.7" /TU="U1966,U1968,U1969,U1970,U1972,U1973" /idTUdmin="U1970" /TUdmin="-287" /isTUend="FALSE" /label="downshifts" S_feature complement(2111683..2111880) /Source="Nicolas_S_feature" /locus_tag="new_2601330_2601527_c" /HighExp="BC, Cold, SMMPr, S1, BI, G135, C30, Lbstat, S5, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S952" CDS complement(2111881..2113692) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /EC_number="2.7.7.-" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3100394, 9387153, 12682299, 16036556, 28386108; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA primase" /protein_id="NP_390400.2" /db_xref="EnsemblGenomes-Gn:BSU25210" /db_xref="EnsemblGenomes-Tr:CAB14451" /db_xref="GOA:P05096" /db_xref="InterPro:IPR002694" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR006295" /db_xref="InterPro:IPR013264" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR019475" /db_xref="InterPro:IPR030846" /db_xref="InterPro:IPR034151" /db_xref="InterPro:IPR036185" /db_xref="InterPro:IPR036977" /db_xref="InterPro:IPR037068" /db_xref="PDB:5GUJ" /db_xref="SubtiList:BG10313" /db_xref="UniProtKB/Swiss-Prot:P05096" /translation="MGNRIPDEIVDQVQKSADIVEVIGDYVQLKKQGRNYFGLCPFHG ESTPSFSVSPDKQIFHCFGCGAGGNVFSFLRQMEGYSFAESVSHLADKYQIDFPDDIT VHSGARPESSGEQKMAEAHELLKKFYHHLLINTKEGQEALDYLLSRGFTKELINEFQI GYALDSWDFITKFLVKRGFSEAQMEKAGLLIRREDGSGYFDRFRNRVMFPIHDHHGAV VAFSGRALGSQQPKYMNSPETPLFHKSKLLYNFYKARLHIRKQERAVLFEGFADVISA VSSDVKESIATMGTSLTDDHVKILRRNVEEIILCYDSDKAGYEATLKASELLQKKGCK VRVAMIPDGLDPDDYIKKFGGEKFKNDIIDASVTVMAFKMQYFRKGKNLSDEGDRLAY IKDVLKEISTLSGSLEQEVYVKQLASEFSLSQESLTEQLSVFSKQNKPADNSGETKTR RAHLTTKARQKRLRPAYENAERLLLAHMLRDRSVIKKVIDRVGFQFNIDEHRALAAYL YAFYEEGAELTPQHLMARVTDDHISQLLSDILMLQVNQELSEAELSDYVKKVLNQRNW SMIKEKEAERAEAERQKDFLRAASLAQEIVTLNRSLK*" /label="dnaG CDS" gene complement(2111881..2113692) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /label="dnaG gene" promotor_-35 2113287..2113293 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2113303 /Source="Nicolas_upshifts" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2113305..2113324 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2113332..2113628 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 9864351" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_054587.1" /db_xref="EnsemblGenomes-Gn:BSU25220" /db_xref="EnsemblGenomes-Tr:CAE01462" /db_xref="GOA:Q7WY63" /db_xref="SubtiList:BG14178" /db_xref="UniProtKB/Swiss-Prot:Q7WY63" /translation="MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLP SALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL*" /label="antE CDS" gene 2113332..2113628 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /label="antE gene" CDS complement(2113726..2114220) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9387153, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390401.2" /db_xref="EnsemblGenomes-Gn:BSU25230" /db_xref="EnsemblGenomes-Tr:CAB14452" /db_xref="InterPro:IPR003791" /db_xref="SubtiList:BG10312" /db_xref="UniProtKB/Swiss-Prot:P17868" /translation="MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVA SFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVM SERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDE GILH*" /label="yqxD CDS" gene complement(2113726..2114220) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /label="yqxD gene" promotor_-10 complement(2114193..2114211) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2114204) /Source="Nicolas_upshifts" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2114221..2114334) /Source="Nicolas_S_feature" /locus_tag="new_2603868_2603981_c" /HighExp="S5, S4, S6, S7, S8, S3, Etha, dia15, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S953" promotor_-35 complement(2114223..2114231) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-35 2114229..2114234 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2114250..2114268 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2114265 /Source="Nicolas_upshifts" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2114319..2114337) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2114334) /Source="Nicolas_upshifts" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2114336..2114413) /Source="Nicolas_S_feature" /locus_tag="new_2603983_2604060_c" /HighExp="Etha, G180, G135, G150, LBGtran, LBGexp, dia15, H2O2, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S954" promotor_-35 complement(2114353..2114358) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2114379..2114398) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2114413) /Source="Nicolas_upshifts" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2114414..2114417) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2114474..2115286) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 20044937" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 20044937; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional ADP-dependent kinase-Pi-dependent pyrophosphorylase / positive regulator of gluconeogenesis" /protein_id="NP_390402.1" /db_xref="EnsemblGenomes-Gn:BSU25240" /db_xref="EnsemblGenomes-Tr:CAB14453" /db_xref="GOA:P54470" /db_xref="InterPro:IPR005177" /db_xref="InterPro:IPR026565" /db_xref="SubtiList:BG11659" /db_xref="UniProtKB/Swiss-Prot:P54470" /translation="MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVE DIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAY GLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPL SQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLN DKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI*" /label="ppsR CDS" gene complement(2114474..2115286) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /label="ppsR gene" CDS complement(2115312..2115950) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of gluconeogenesis" /protein_id="NP_390403.1" /db_xref="EnsemblGenomes-Gn:BSU25250" /db_xref="EnsemblGenomes-Tr:CAB14454" /db_xref="GOA:O34994" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016842" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3FV6" /db_xref="PDB:3FWR" /db_xref="PDB:3FWS" /db_xref="SubtiList:BG13768" /db_xref="UniProtKB/Swiss-Prot:O34994" /translation="MSTIELNKRQEHILQIVKENGPITGEHIAEKLNLTRATLRPDLA ILTMSGFLEARPRVGYFYTGKTGTQLLADKLKKLQVKDFQSIPVVIHENVSVYDAICT MFLEDVGTLFVVDRDAVLVGVLSRKDLLRASIGQQELTSVPVHIIMTRMPNITVCRRE DYVMDIAKHLIEKQIDALPVIKDTDKGFEVIGRVTKTNMTKILVSLSENEIL*" /label="ccpN CDS" gene complement(2115312..2115950) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /label="ccpN gene" S_feature complement(2115951..2116082) /Source="Nicolas_S_feature" /locus_tag="new_2605598_2605729_c" /HighExp="G135, dia5, G180, G150, dia15, H2O2, LBGexp, Lbexp, Oxctl, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999, 0.998" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S955" promotor_-10 complement(2116076..2116095) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" CDS complement(2116083..2118122) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (beta subunit)" /protein_id="NP_390404.2" /db_xref="EnsemblGenomes-Gn:BSU25260" /db_xref="EnsemblGenomes-Tr:CAB14455" /db_xref="GOA:P54381" /db_xref="InterPro:IPR006194" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR015944" /db_xref="SubtiList:BG11658" /db_xref="UniProtKB/Swiss-Prot:P54381" /translation="MSKQDLLLEIGLEEMPARFLNESMVQLGDKLTGWLKEKNITHGE VKLFNTPRRLAVFVKDVAEKQDDIKEEAKGPAKKIALDADGNWTKAAIGFSKGQGANV EDLYIKEVKGIEYVFVQKFQAGQETKSLLPELSGLITSLHFPKNMRWGNEDLRYIRPI KWIVALFGQDVIPFSITNVESGRTTQGHRFLGHEVSIESPSAYEEQLKGQHVIADPSV RKQMIQSQLETMAAENNWSIPVDEDLLDEVNHLVEYPTALYGSFESEFLSIPEEVLVT TMKEHQRYFPVKDKNGDLLPHFITVRNGNSHAIENVARGNEKVLRARLSDASFFYKED QKLNIDANVKKLENIVFHEELGSLADKVRRVTSIAEKLAVRLQADEDTLKHVKRAAEI SKFDLVTHMIYEFPELQGIMGEKYARMLGEDEAVAAAVNEHYMPRSAGGETPSTFTGA VVAMADKLDTIASFFSIGVIPTGSQDPYGLRRQASGIVAILLDRNWGISFEELLTFVQ TDKENELLDFFTQRLKYVLNAEQIRHDVIDAVLESSELEPYSALHKAQVLEQKLGAPG FKETAEALGRVISISKKGVRGDIQPDLFENEYEAKLFDAYQTAKQNLQENFSKKDYEA ALASLAALKEPIDAYFDHTMVIADNESLKANRLAQMVSLADEIKSFANMNALIVK*" /label="glyS CDS" gene complement(2116083..2118122) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /label="glyS gene" upshifts complement(2116085) /Source="Nicolas_upshifts" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2116110..2116117) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" downshifts complement(2116129) /Source="Nicolas_upshifts" /id="D1310" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="6.14024" /MaxDrop="3.62589" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" downshifts complement(2116195) /Source="Nicolas_upshifts" /id="D1311" /incds=1 /nref=10 /ntot=162 /MaxReadThrough="6.17154" /MaxDrop="3.30313" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1386" /isTUend="FALSE" /label="downshifts" CDS complement(2118115..2119002) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390405.1" /db_xref="EnsemblGenomes-Gn:BSU25270" /db_xref="EnsemblGenomes-Tr:CAB14456" /db_xref="GOA:P54380" /db_xref="InterPro:IPR002310" /db_xref="InterPro:IPR006194" /db_xref="SubtiList:BG11657" /db_xref="UniProtKB/Swiss-Prot:P54380" /translation="MNIQDMILTLQKHWSSQGCVLMQAYDVEKGAGTMSPYTFLRSIG PEPWKVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGID PLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECKPVSVEITYG IERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFQLFSTYEK EAIKQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIARVRNLARKVAKTYY EEREKLGFPMLKGEGSSHE*" /label="glyQ CDS" gene complement(2118115..2119002) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /label="glyQ gene" misc_RNA complement(2119085..2119259) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /product="T-box riboswitch controlling synthesis of glycine-tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201, 15890195, 26229106" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201, 15890195, 26229106; Product type n : RNA" /label="tboG RNA" gene complement(2119085..2119259) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /label="tboG gene" downshifts complement(2119119) /Source="Nicolas_upshifts" /id="D1312" /incds=0 /nref=70 /ntot=220 /MaxReadThrough="6.60948" /MaxDrop="5.42847" /score="18.9025126" /energy="-23.3" /TU="U1972,U1973,U1975" /idTUdmin="U1976" /TUdmin=178 /isTUend="FALSE" /label="downshifts" promotor_-35 2119234..2119239 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2119255..2119273 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2119263..2119282) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" S_feature 2119265..2120677 /Source="Nicolas_S_feature" /locus_tag="new_2608912_2610324" /HighExp="C30, S8, Gly, BT, G135, Fru, S6, C90, Lbstat, Mal" /AntisenseName="recO" /AntisenseCor="0.22892689952134901" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S956" upshifts 2119265 /Source="Nicolas_upshifts" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2119275) /Source="Nicolas_upshifts" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2119297..2119304) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2119299..2120066) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10323239, 15186413, 16061691, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10323239, 15186413, 16061691, 26001966; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA double strand break repair and homologous recombination factor" /protein_id="NP_390406.2" /db_xref="EnsemblGenomes-Gn:BSU25280" /db_xref="EnsemblGenomes-Tr:CAB14457" /db_xref="GOA:P42095" /db_xref="InterPro:IPR003717" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022572" /db_xref="SubtiList:BG11189" /db_xref="UniProtKB/Swiss-Prot:P42095" /translation="MLTKCEGIVLRTNDYGETNKIVTLLTREHGKIGVMARGAKKPNS RLSAVSQPFLYGSFLMQKTSGLGTLQQGEMILSMRGIREDLFLTAYAAYVAELVDRGT EEKKPNPYLFEFILESLKQLNEGTDPDVITFIVQMKMLGVMGLYPELNHCVHCKSQDG TFHFSVRDNGFICHRCFEKDPYRIPIKPQTARLLRLFYYFDLSRLGNVSLKEETKAEL KQVIDLYYEEYSGLYLKSKRFLDQMESMKHLMGENKS*" /label="recO CDS" gene complement(2119299..2120066) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /label="recO gene" CDS complement(2120103..2120246) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097761.1" /db_xref="EnsemblGenomes-Gn:BSU25289" /db_xref="EnsemblGenomes-Tr:CAX52661" /db_xref="InterPro:IPR025617" /db_xref="UniProtKB/Swiss-Prot:C0H452" /translation="MLNFTWNVFSQTGNVDTYLLFKELEKENMERPEELEDELARFDY PIL*" /label="yqzL CDS" gene complement(2120103..2120246) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /label="yqzL gene" S_feature complement(2120247..2120393) /Source="Nicolas_S_feature" /locus_tag="new_2609894_2610040_c" /HighExp="Lbstat, T1.30H, T2.0H, M9-stat, S2, T3.0H, S5, M0t90, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.999, 0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S957" CDS complement(2120394..2121299) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maturation of 16S RNA and assembly of 30S ribosomal subunit GTPase" /protein_id="NP_390407.1" /db_xref="EnsemblGenomes-Gn:BSU25290" /db_xref="EnsemblGenomes-Tr:CAB14458" /db_xref="GOA:P42182" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005662" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030388" /db_xref="SubtiList:BG11188" /db_xref="UniProtKB/Swiss-Prot:P42182" /translation="MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTR NKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYG KGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNN IETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIE SIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLEL WVKVQKDWRNKMSQLRDFGFKEDEY*" /label="era CDS" gene complement(2120394..2121299) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /label="era gene" CDS complement(2121280..2121690) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /EC_number="3.5.4.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2526291, 8157589, 10217788, 11851403, 22720735, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2526291, 8157589, 10217788, 11851403, 22720735, 25890046; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidine/deoxycytidine deaminase" /protein_id="NP_390408.1" /db_xref="EnsemblGenomes-Gn:BSU25300" /db_xref="EnsemblGenomes-Tr:CAB14459" /db_xref="GOA:P19079" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1JTK" /db_xref="PDB:1UWZ" /db_xref="PDB:1UX0" /db_xref="PDB:1UX1" /db_xref="SubtiList:BG10477" /db_xref="UniProtKB/Swiss-Prot:P19079" /translation="MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIE NAAYSMCNCAERTALFKAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVI VVLTNLQGQIKEMTVEELLPGAFSSEDLHDERKL*" /label="cdd CDS" gene complement(2121280..2121690) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /label="cdd gene" promotor_-10 complement(2121728..2121747) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2121739) /Source="Nicolas_upshifts" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2121741..2121808) /Source="Nicolas_S_feature" /locus_tag="new_2611388_2611455_c" /HighExp="Oxctl, H2O2, G180, G150, GM 120, S1, G135, Diami, LBGtran, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S958" promotor_-35 complement(2121762..2121765) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2121809..2122180) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /EC_number="2.7.1.66" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12923107, 17535816, 19935659, 28872301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenol kinase" /protein_id="NP_390409.2" /db_xref="EnsemblGenomes-Gn:BSU25310" /db_xref="EnsemblGenomes-Tr:CAB14460" /db_xref="GOA:P19638" /db_xref="InterPro:IPR000829" /db_xref="InterPro:IPR033717" /db_xref="InterPro:IPR036945" /db_xref="SubtiList:BG11040" /db_xref="UniProtKB/Swiss-Prot:P19638" /translation="MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAV LICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAG AVCVFAVISCIIGLLIFLPKL*" /label="unpK CDS" gene complement(2121809..2122180) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /label="unpK gene" CDS complement(2122161..2122634) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16511207, 16818608, 19181801, 20639334, 20807199, 23273979, 23638028, 24511998, 24901994, 28031281; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease involved in 70S ribosomes quality control" /protein_id="NP_390410.2" /db_xref="EnsemblGenomes-Gn:BSU25320" /db_xref="EnsemblGenomes-Tr:CAB14461" /db_xref="GOA:P46347" /db_xref="InterPro:IPR002036" /db_xref="InterPro:IPR020549" /db_xref="InterPro:IPR023091" /db_xref="SubtiList:BG11656" /db_xref="UniProtKB/Swiss-Prot:P46347" /translation="MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVT IVSNDDIHQINKEYRGKDAPTDVISFALEEEGEGEIEIVGAEMPPVLGDIIISADRTR EQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDAYGLKRS*" /label="rnrY CDS" gene complement(2122161..2122634) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /label="rnrY gene" CDS complement(2122635..2124770) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751502, 26240071, 27378384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751502, 26240071, 27378384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="c-di-AMP-degrading phosphodiesterases" /protein_id="NP_390411.1" /db_xref="EnsemblGenomes-Gn:BSU25330" /db_xref="EnsemblGenomes-Tr:CAB14462" /db_xref="GOA:P46344" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR011621" /db_xref="InterPro:IPR011624" /db_xref="SubtiList:BG11655" /db_xref="UniProtKB/Swiss-Prot:P46344" /translation="MLKKKAKTKSSSKKWSSFKNARSMHVLLYLLLAAIMFALLFVHV KPETLDLDLFSVSDKTIYAPATVEDQKATEEKKQAAEDAVEDQYTLKKEYTDNRIDLV SSIFDSISEVKKSSEEGSKSPSEKSMVKSVKDKLTSDVNDSISEDSIKTLLKADSEDF SFVRDTVITAVNTVMSSEIPSDKLSDAKDKVEKELKSNSIPSKYLGAATEIGRFAIIP NYVFDPKATEAKRQEASDNVQQVQIKQGQVLVEENDLIDREVYRKLELTGLLNNSNLF KPISGLLIMIGLFIATLVYYFEKQKQNLKFKNQSILLFSIITTLLLVIMEVVSLFQKM EYNNIGYLVPIAAGAILIKLLMNERIAILGSIILAICGSMMFNQGVTGTFNYVIGIYY LISGISGVLFLGKHNARSKILQTGLFVAFINMVVVLSLLLIQNTALSGLEIGTLMLMG VVSGFASSVLIIGLMPFFETGFGILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMV ANLSEAACEAVGANGLLARVGAYYHDLGKTKRPQYFIENQMNIDNPHDKLSPQLSKNI IISHTTDGANMLRSYKFPKELVDIAEQHHGTSLLKFFYYKAKEKGDQITEEEFRYPGP KPQSKEAAIISVADSVEAAVRSMHNPNPERIEKLVRGIISDKLQDGQFSECDLTFKEL DTIAKTLCATLKGIFHSRIEYPEATKKVK*" /label="pgpH CDS" gene complement(2122635..2124770) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /label="pgpH gene" promotor_-35 2124614..2124619 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2124634 /Source="Nicolas_upshifts" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2124635..2124653 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2124849..2125808) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12762842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12762842; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="phosphate starvation-induced protein" /protein_id="NP_390412.2" /db_xref="EnsemblGenomes-Gn:BSU25340" /db_xref="EnsemblGenomes-Tr:CAB14476" /db_xref="GOA:P46343" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11337" /db_xref="UniProtKB/Swiss-Prot:P46343" /translation="MTEHLLAMNQKLKNPDEALSLFGNQDSFLKLMEKDLNLNIITRG ETIYVSGDDESFQIADRLLGSLLALIRKGIEISERDVIYAIKMAKKNELEYFESMYEE EITKNAKGKSIRVKTMGQREYVAAMKRNDLVFGIGPAGTGKTYLAVVKAVHALKNGHI KKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPLYDALHDVLGADHTERLMERGIIEI APLAYMRGRTLDDAYVILDEAQNTTPAQMKMFLTRLGFGSKMIITGDVSQIDLPKGVK SGLAVAKEMLKGIDGISMIELDQTDVVRHPLVAKIIEAYDKQN*" /label="phoH CDS" gene complement(2124849..2125808) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /label="phoH gene" downshifts complement(2124864) /Source="Nicolas_upshifts" /id="D1313" /incds=0 /nref=1 /ntot=63 /MaxReadThrough="6.04676" /MaxDrop="4.50442" /score="9.12152318" /energy="-13.1" /TU="U1975,U1976,U1977" /idTUdmin="U1978" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" CDS complement(2125805..2127001) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14523133, 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage IV sporulation protein; putative UDP-glucose-4-epimerase" /protein_id="NP_390413.2" /db_xref="EnsemblGenomes-Gn:BSU25350" /db_xref="EnsemblGenomes-Tr:CAB14477" /db_xref="GOA:P54469" /db_xref="InterPro:IPR010690" /db_xref="SubtiList:BG11654" /db_xref="UniProtKB/Swiss-Prot:P54469" /translation="MKNKWLSFFSGKVQLELTGRGIERLLNECTRQGIPVFHVKKKKE AVSLYIQLQDVHAFRRVRSKFKCKARFINRKGFPFLLLKSKLNIGFTIGFAIFFILLF LLSNMVWKIDVTGAKPETEHQMRQHLNEIGVKKGRLQFLMMSPEKIQKSLTNGIDNIT WVGVDLKGTTIHMKVVEKNEPEKEKYVSPRNIVAKKKATITRMFVQKGQPMAAIHDHV EKGQLLVSGLIGSEDHQQEVASKAEIYGETWYRSEVTVPLETLFNVYTGKVRTKHKLS FGSLAIPIWGMTFKKEELKHPKTEQEKHSLHFLGFKLPVSYVKEQTRESEEALRKYTK EEAVQEGIKLGKQDVEDKIGENGEVKSEKVLHQTVENGKVKLIILYQVIEDIVQTTPI VRETEE*" /label="yqfD CDS" gene complement(2125805..2127001) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /label="yqfD gene" promotor_-10 complement(2125872..2125891) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2125877) /Source="Nicolas_upshifts" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2125905..2125912) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2125952..2125970) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-10" upshifts complement(2125964) /Source="Nicolas_upshifts" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="upshifts" promotor_-35 complement(2125985..2125991) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-35" upshifts complement(2126179) /Source="Nicolas_upshifts" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="upshifts" promotor_-10 complement(2126193..2126204) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-10" promotor_-35 complement(2126219..2126225) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-35" CDS complement(2127020..2127301) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12662922" /codon_start=1 /transl_table=11 /product="conserved sporulation protein of unknown function" /protein_id="NP_390414.1" /db_xref="EnsemblGenomes-Gn:BSU25360" /db_xref="EnsemblGenomes-Tr:CAB14478" /db_xref="InterPro:IPR022476" /db_xref="InterPro:IPR022477" /db_xref="SubtiList:BG11653" /db_xref="UniProtKB/Swiss-Prot:P54468" /translation="MGQRKNRMKAWLTRALEIPPDVMMDLPRITMVGRLHIYIENHRG LLLFSENEVRLMLKQGQCIISGKNFVIKAILPEEILLEGTIDVVRYVES*" /label="yqfC CDS" gene complement(2127020..2127301) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /label="yqfC gene" CDS complement(2127358..2127777) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390415.2" /db_xref="EnsemblGenomes-Gn:BSU25370" /db_xref="EnsemblGenomes-Tr:CAB14479" /db_xref="GOA:P54467" /db_xref="InterPro:IPR016788" /db_xref="SubtiList:BG11652" /db_xref="UniProtKB/Swiss-Prot:P54467" /translation="MEDLLTNPLIIAAIIGIISAIFGKKSKEEKQNSQKRKKPQHVQS ASPQKKQSKEDAPAPIPNRMEQARREAEERRRETARNLKGLERDLAAAKQKTVYTKQK MLQVNKDTVVQGIVLGEVFGPPRAKKPHRTMRPARKN*" /label="yqfB CDS" gene complement(2127358..2127777) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /label="yqfB gene" downshifts complement(2127372) /Source="Nicolas_upshifts" /id="D1314" /incds=0 /nref=232 /ntot=257 /MaxReadThrough="4.55662" /MaxDrop="7.47609" /score="-3.87904232" /energy="-16.8" /TU="U1978" /idTUdmin="U1980" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2127802..2128797) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12501411, 22753055" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12501411, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="flotillin-like protein involved in membrane lipid rafts" /protein_id="NP_390416.1" /db_xref="EnsemblGenomes-Gn:BSU25380" /db_xref="EnsemblGenomes-Tr:CAB14480" /db_xref="GOA:P54466" /db_xref="InterPro:IPR022853" /db_xref="SubtiList:BG11651" /db_xref="UniProtKB/Swiss-Prot:P54466" /translation="MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIF TLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRAN IELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANI ERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEIL SIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKV VEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS*" /label="floA CDS" gene complement(2127802..2128797) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /label="floA gene" CDS complement(2128819..2130132) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22753055; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound peptidase of unkwnown function" /protein_id="NP_390417.1" /db_xref="EnsemblGenomes-Gn:BSU25390" /db_xref="EnsemblGenomes-Tr:CAB14481" /db_xref="GOA:P54465" /db_xref="InterPro:IPR002810" /db_xref="InterPro:IPR002825" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11650" /db_xref="UniProtKB/Swiss-Prot:P54465" /translation="MLQIKGFRAALLGIFLLSLLGVQLNAKAEKQTVYVIPVEKNVEQ GLASFLSRSLQDAKDAHADHIILDINTPGGLVKSAIDMADLITESEIPVTAYVNKRAL SAGAYIALQADHIYMAPGGKMGAAAIVDGQGNAADQKAQSLWLAEMEDAAVKNNRDPK YALAMADPDIDAKEVGAPKGDLLTLNADKAIEVGYSEGTADNLSTLVKKLGFEKAQIS YAKESFAEKTARWLTNPVIVPILLTIAFLGLTVELFSPGVGLPGTAGLIALLLFFYGH LAAGLAGYETVLLFIAGVILILLEIFLPGGIIGLLGLGAIIASLFLAAGSFTVMAVSL LIASAVSITAFILLTRVLGKRMKFFKKLILNDSTNTESGYVSNQTRTDLMGKVGITFT PLRPSGTVIIDDERLDVVSEGSFTEKDKKVKVIKVEGSRIVVREI*" /label="nfeDA CDS" gene complement(2128819..2130132) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /label="nfeDA gene" promotor_-10 complement(2130168..2130183) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-10" upshifts complement(2130185) /Source="Nicolas_upshifts" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="upshifts" promotor_-35 complement(2130196..2130205) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-35" CDS complement(2130263..2130709) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17284460, 22720735, 25149203" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function with tRNA aminoacid amidase domain" /protein_id="NP_390418.1" /db_xref="EnsemblGenomes-Gn:BSU25400" /db_xref="EnsemblGenomes-Tr:CAB14482" /db_xref="GOA:P54464" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR019004" /db_xref="InterPro:IPR023168" /db_xref="PDB:1NG6" /db_xref="SubtiList:BG11649" /db_xref="UniProtKB/Swiss-Prot:P54464" /translation="MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDS LTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRT IVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS*" /label="yqeY CDS" gene complement(2130263..2130709) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /label="yqeY gene" downshifts complement(2130276) /Source="Nicolas_upshifts" /id="D1315" /incds=0 /nref=248 /ntot=267 /MaxReadThrough="5.1355" /MaxDrop="8.31948" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" downshifts complement(2130474) /Source="Nicolas_upshifts" /id="D1316" /incds=1 /nref=1 /ntot=34 /MaxReadThrough="8.99916" /MaxDrop="1.9798" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(2130724..2130897) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 22720735, 23002217, 25035996" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 22720735, 23002217, 25035996; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S21" /protein_id="NP_390419.1" /db_xref="EnsemblGenomes-Gn:BSU25410" /db_xref="EnsemblGenomes-Tr:CAB14483" /db_xref="GOA:P21478" /db_xref="InterPro:IPR001911" /db_xref="InterPro:IPR018278" /db_xref="SubtiList:BG11648" /db_xref="UniProtKB/Swiss-Prot:P21478" /translation="MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVK RKKKSEAARKRKF*" /label="rpsU CDS" gene complement(2130724..2130897) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /label="rpsU gene" misc_feature 2130833..2130837 /Source="Nicolas_upshift_promotors" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2130838 /Source="Nicolas_upshifts" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2130958..2130977) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2130973) /Source="Nicolas_upshifts" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2130991..2130998) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2131016..2131021 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2131036 /Source="Nicolas_upshifts" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2131037..2131055 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2131070..2131993 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/anion cotransporter" /protein_id="NP_390420.2" /db_xref="EnsemblGenomes-Gn:BSU25420" /db_xref="EnsemblGenomes-Tr:CAB14484" /db_xref="GOA:P54463" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /db_xref="SubtiList:BG11647" /db_xref="UniProtKB/Swiss-Prot:P54463" /translation="MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHP LKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAI KMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGA DVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIG TCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAH FSLLFNVVTALLFLPLTNLFYRLIHLLIPAK*" /label="yqeW CDS" gene 2131070..2131993 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /label="yqeW gene" CDS complement(2132030..2133385) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA N(6)-threonylcarbamoyladenosine (t(6)A) methylthiotransferase" /protein_id="NP_390421.1" /db_xref="EnsemblGenomes-Gn:BSU25430" /db_xref="EnsemblGenomes-Tr:CAB14485" /db_xref="GOA:P54462" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006467" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR034557" /db_xref="SubtiList:BG11646" /db_xref="UniProtKB/Swiss-Prot:P54462" /translation="MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVI NTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDR EKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFC IIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSEL DTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYT MEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSK RTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEE ENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLS S*" /label="mtaB CDS" gene complement(2132030..2133385) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /label="mtaB gene" downshifts complement(2132036) /Source="Nicolas_upshifts" /id="D1317" /incds=0 /nref=208 /ntot=260 /MaxReadThrough="1.95578" /MaxDrop="6.05381" /score="30.7201786" /energy="-11.3" /TU="NA" /idTUdmin="U1983" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2133385..2134155) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /EC_number="2.1.1.193" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9023197, 10383760, 14517985, 16014871, 16431987, 22925577, 24598751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylase of U1498 in 16S rRNA" /protein_id="NP_390422.1" /db_xref="EnsemblGenomes-Gn:BSU25440" /db_xref="EnsemblGenomes-Tr:CAB14486" /db_xref="GOA:P54461" /db_xref="InterPro:IPR006700" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1VHK" /db_xref="SubtiList:BG11645" /db_xref="UniProtKB/Swiss-Prot:P54461" /translation="MQRYFIELTKQQIEEAPTFSITGEEVHHIVNVMRMNEGDQIICC SQDGFEAKCELQSVSKDKVSCLVIEWTNENRELPIKVYIASGLPKGDKLEWIIQKGTE LGAHAFIPFQAARSVVKLDDKKAKKKRERWTKIAKEAAEQSYRNEVPRVMDVHSFQQL LQRMQDFDKCVVAYEESSKQGEISAFSAIVSSLPKGSSLLIVFGPEGGLTEAEVERLT EQDGVTCGLGPRILRTETAPLYALSAISYQTELLRGDQ*" /label="rsmE CDS" gene complement(2133385..2134155) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /label="rsmE gene" CDS complement(2134178..2135113) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17215866, 18611379; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 methyltransferase" /protein_id="NP_390423.2" /db_xref="EnsemblGenomes-Gn:BSU25450" /db_xref="EnsemblGenomes-Tr:CAB14487" /db_xref="GOA:P54460" /db_xref="InterPro:IPR004498" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11644" /db_xref="UniProtKB/Swiss-Prot:P54460" /translation="MKWSELSIHTTHEAVEPISNILHEAGASGVVIEDPLDLIKEREN VYGEIYQLDPNDYPDEGVIVKAYLPVNSFLGETVDGIKETINNLLLYNIDLGRNHITI SEVNEEEWATAWKKYYHPVKISEKFTIVPTWEEYTPVHTDELIIEMDPGMAFGTGTHP TTVLCIQALERFVQKGDKVIDVGTGSGILSIAAAMLEAESVHAYDLDPVAVESARLNL KLNKVSDIAQVKQNNLLDGIEGEHDVIVANILAEVILRFTSQAYSLLKEGGHFITSGI IGHKKQEVKEALEQAGFTIVEILSMEDWVSIIAKK*" /label="prmA CDS" gene complement(2134178..2135113) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /label="prmA gene" CDS complement(2135138..2136265) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10383760, 10658654, 16385044, 16952052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10383760, 10658654, 16385044, 16952052; Product type f: factor" /codon_start=1 /transl_table=11 /product="co-factor of molecular chaperone" /protein_id="NP_390424.2" /db_xref="EnsemblGenomes-Gn:BSU25460" /db_xref="EnsemblGenomes-Tr:CAB14488" /db_xref="GOA:P17631" /db_xref="InterPro:IPR001305" /db_xref="InterPro:IPR001623" /db_xref="InterPro:IPR002939" /db_xref="InterPro:IPR008971" /db_xref="InterPro:IPR012724" /db_xref="InterPro:IPR018253" /db_xref="InterPro:IPR036410" /db_xref="InterPro:IPR036869" /db_xref="SubtiList:BG10665" /db_xref="UniProtKB/Swiss-Prot:P17631" /translation="MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDE KFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGG GTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPE TCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKIN VTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTF AQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVT PTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD*" /label="dnaJ CDS" gene complement(2135138..2136265) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /label="dnaJ gene" misc_feature 2136182..2136185 /Source="Nicolas_upshift_promotors" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2136193 /Source="Nicolas_upshifts" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2136266..2136443) /Source="Nicolas_S_feature" /locus_tag="new_2625913_2626090_c" /HighExp="Heat, dia15, H2O2, Diami, G135, G150, G180, LPhT, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.357489" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S959" misc_RNA 2136305..2136395 /gene="surC" /locus_tag="BSU_misc_RNA_79" /product="sporulation-related small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surC RNA" gene 2136305..2136395 /gene="surC" /locus_tag="BSU_misc_RNA_79" /label="surC gene" CDS complement(2136465..2138300) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular chaperone, ATP-dependent" /protein_id="NP_390425.1" /db_xref="EnsemblGenomes-Gn:BSU25470" /db_xref="EnsemblGenomes-Tr:CAB14489" /db_xref="GOA:P17820" /db_xref="InterPro:IPR012725" /db_xref="InterPro:IPR013126" /db_xref="InterPro:IPR018181" /db_xref="InterPro:IPR029047" /db_xref="InterPro:IPR029048" /db_xref="PDB:2FZO" /db_xref="SubtiList:BG10664" /db_xref="UniProtKB/Swiss-Prot:P17820" /translation="MSKVIGIDLGTTNSCVAVLEGGEPKVIANAEGNRTTPSVVAFKN GERQVGEVAKRQSITNPNTIMSIKRHMGTDYKVEIEGKDYTPQEVSAIILQHLKSYAE SYLGETVSKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDE DQTILVYDLGGGTFDVSILELGDGVFEVRSTAGDNRLGGDDFDQVIIDHLVSEFKKEN GIDLSKDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGEAGPLHLELTLTRAKFE ELSSHLVERTMGPVRQALQDAGLSASEIDKVILVGGSTRIPAVQEAIKKETGKEAHKG VNPDEVVALGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK SQVFSTAADNQTAVDIHVLQGERPMSADNKTLGRFQLTDIPPAPRGVPQIEVSFDIDK NGIVNVRAKDLGTGKEQNITIKSSSGLSDEEIERMVKEAEENADADAKKKEEIEVRNE ADQLVFQTEKTLKDLEGKVDEEQVKKANDAKDALKAAIEKNEFEEIKAKKDELQTIVQ ELSMKLYEEAAKAQQAQGGANAEGKADDNVVDAEYEEVNDDQNKK*" /label="dnaK CDS" gene complement(2136465..2138300) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /label="dnaK gene" downshifts complement(2136488) /Source="Nicolas_upshifts" /id="D1318" /incds=0 /nref=130 /ntot=247 /MaxReadThrough="8.0737" /MaxDrop="4.023" /score="21.9400858" /energy="-13.4" /TU="U1983,U1985" /idTUdmin="U1984" /TUdmin=3565 /isTUend="FALSE" /label="downshifts" CDS complement(2138324..2138887) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nucleotide exchange factor for DnaK activity" /protein_id="NP_390426.1" /db_xref="EnsemblGenomes-Gn:BSU25480" /db_xref="EnsemblGenomes-Tr:CAB14490" /db_xref="GOA:P15874" /db_xref="InterPro:IPR000740" /db_xref="InterPro:IPR009012" /db_xref="InterPro:IPR013805" /db_xref="PDB:2G61" /db_xref="SubtiList:BG10663" /db_xref="UniProtKB/Swiss-Prot:P15874" /translation="MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINE LQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQV EADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGS NIVVEEMQKGYKLKDRVIRPSMVKVNQ*" /label="grpE CDS" gene complement(2138324..2138887) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /label="grpE gene" S_feature complement(2138888..2138958) /Source="Nicolas_S_feature" /locus_tag="new_2628535_2628605_c" /HighExp="LPhT, dia15, Heat, Etha, Diami, dia5, H2O2, T-0.40H, T0.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S960" CDS complement(2138959..2139990) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10555317, 12082092, 15109714, 16872404, 16585746, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10555317, 12082092, 15109714, 16872404, 16585746, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of heat-shock genes" /protein_id="NP_390427.1" /db_xref="EnsemblGenomes-Gn:BSU25490" /db_xref="EnsemblGenomes-Tr:CAB14491" /db_xref="GOA:P25499" /db_xref="InterPro:IPR002571" /db_xref="InterPro:IPR021153" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10662" /db_xref="UniProtKB/Swiss-Prot:P25499" /translation="MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRN EMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFE LEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVEN KTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDA LRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGI SIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLS KALTSLYDE*" /label="hrcA CDS" gene complement(2138959..2139990) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /label="hrcA gene" promotor_-10 complement(2140031..2140050) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2140044) /Source="Nicolas_upshifts" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2140065..2140072) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2140071..2141210) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /EC_number="1.3.98.3" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8757728, 9371469, 10498703, 12196143, 19944166" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8757728, 9371469, 10498703, 12196143, 19944166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_390428.2" /db_xref="EnsemblGenomes-Gn:BSU25500" /db_xref="EnsemblGenomes-Tr:CAB14492" /db_xref="GOA:P54304" /db_xref="InterPro:IPR004559" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010723" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG11395" /db_xref="UniProtKB/Swiss-Prot:P54304" /translation="MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINT IAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSA EKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLM FGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAE MYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTV NVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSL DGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL*" /label="hemN CDS" gene complement(2140071..2141210) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /label="hemN gene" promotor_-10 complement(2141083..2141094) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-10" upshifts complement(2141087) /Source="Nicolas_upshifts" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="upshifts" promotor_-35 complement(2141108..2141114) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-35" CDS complement(2141263..2143101) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12511492, 17110332, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal elongation factor, GTPase" /protein_id="NP_390429.1" /db_xref="EnsemblGenomes-Gn:BSU25510" /db_xref="EnsemblGenomes-Tr:CAB14493" /db_xref="GOA:P37949" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006297" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR013842" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035654" /db_xref="SubtiList:BG10441" /db_xref="UniProtKB/Swiss-Prot:P37949" /translation="MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQR EMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSL AACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDV IGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDPEAPLKALIFDSLYDAYRGVVA YIRVVEGTVKPGQKIKMMATGKEFEVTEVGVFTPKATPTNELTVGDVGFLTASIKNVG DTRVGDTITSAANPAEEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSL QYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKV VVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRV SIIYDMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSF IVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGQKIVARSTIKAMRKNVLAKCYG GDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKKQ*" /label="lepA CDS" gene complement(2141263..2143101) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /label="lepA gene" downshifts complement(2141285) /Source="Nicolas_upshifts" /id="D1319" /incds=0 /nref=15 /ntot=213 /MaxReadThrough="5.2925" /MaxDrop="3.979" /score="5.45344919" /energy="-14" /TU="U1985" /idTUdmin="U1984" /TUdmin="-1232" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2143136..2143155) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2143153) /Source="Nicolas_upshifts" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2143171..2143175) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2143235..2143573) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390430.1" /db_xref="EnsemblGenomes-Gn:BSU25520" /db_xref="EnsemblGenomes-Tr:CAB14494" /db_xref="InterPro:IPR020534" /db_xref="SubtiList:BG10440" /db_xref="UniProtKB/Swiss-Prot:P38425" /translation="MIAYFGKCLLLVTIMFLGVLFGMQQANHGMLSMKGYHDPSLKGA FTLTDGKDNEKEASILGETVTAKDLVEKQKELEKVETFNMFSKAGKALSDTVTNTAQS MYEWIRDMNQ*" /label="yqxA CDS" gene complement(2143235..2143573) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /label="yqxA gene" downshifts complement(2143241) /Source="Nicolas_upshifts" /id="D1320" /incds=0 /nref=11 /ntot=43 /MaxReadThrough="2.553" /MaxDrop="3.8126" /score="5.45344919" /energy="-14" /TU="NA" /idTUdmin="U1986" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2143590..2144795) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17376078, 23834622" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17376078, 23834622; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore autolysin (stage II sporulation)" /protein_id="NP_390431.1" /db_xref="EnsemblGenomes-Gn:BSU25530" /db_xref="EnsemblGenomes-Tr:CAB14495" /db_xref="GOA:P37968" /db_xref="InterPro:IPR010897" /db_xref="SubtiList:BG10439" /db_xref="UniProtKB/Swiss-Prot:P37968" /translation="MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLR PELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSIN LEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEK QQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVG DMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIID IHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTG VFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVN AASGETKKQ*" /label="spoIIP CDS" gene complement(2143590..2144795) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /label="spoIIP gene" promotor_-10 complement(2144815..2144833) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2144827) /Source="Nicolas_upshifts" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2144849..2144854) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2144858..2145964) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /EC_number="3.4.24.78" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10666631, 10986255, 12807468, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666631, 10986255, 12807468, 23927687; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protease" /protein_id="NP_390432.1" /db_xref="EnsemblGenomes-Gn:BSU25540" /db_xref="EnsemblGenomes-Tr:CAB14496" /db_xref="GOA:P22322" /db_xref="InterPro:IPR005080" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10438" /db_xref="UniProtKB/Swiss-Prot:P22322" /translation="MKKSELDVNQYLIRTDLAVETKEAMANQQAVPTKEIKGFIEKER DHGGIKIRTVDVTKEGAELSGKKEGRYLTLEAQGIRENDSEMQEKVSAVFAEEFSAFL ENLNISKDASCLIVGLGNWNVTPDALGPMAVENLLVTRHLFKLQPENVQEGYRPVSAF APGVMGITGIETSDIIKGVIEQSKPDFVIAIDALAARAVERVNTTIQISDTGIHPGSG VGNKRKDLSKDTLGVPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDNRPSRSLVP AGMTFGKKKVLTEDDLPDQKQRQSFLGIVGTLQEDEKRQLIHEVLSPLGHNLMVTPKE VDSFIDDMANVLANGLNTALHEKVSQENKGSYNH*" /label="gpr CDS" gene complement(2144858..2145964) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /label="gpr gene" promotor_-10 complement(2145992..2146003) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2145999) /Source="Nicolas_upshifts" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2146018..2146024) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2146063..2146066 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2146079 /Source="Nicolas_upshifts" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2146082..2146101 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2146093..2146167 /Source="Nicolas_S_feature" /locus_tag="new_2635740_2635814" /HighExp="HiTm, LPhT, UNK1, HiOs, dia5, aero, MG 15, SMM, Lbtran, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S961" CDS 2146168..2146434 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16629673, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16629673, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S20 (BS20)" /protein_id="NP_390433.2" /db_xref="EnsemblGenomes-Gn:BSU25550" /db_xref="EnsemblGenomes-Tr:CAB14497" /db_xref="GOA:P21477" /db_xref="InterPro:IPR002583" /db_xref="InterPro:IPR036510" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11643" /db_xref="UniProtKB/Swiss-Prot:P21477" /translation="MPNIKSAIKRTKTNNERRVHNATIKSAMRTAIKQVEASVANNEA DKAKTALTEAAKRIDKAVKTGLVHKNTAARYKSRLAKKVNGLSA*" /label="rpsT CDS" gene 2146168..2146434 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /label="rpsT gene" downshifts 2146423 /Source="Nicolas_upshifts" /id="D1321" /incds=0 /nref=244 /ntot=274 /MaxReadThrough="2.22204" /MaxDrop="8.54705" /score="33.3621187" /energy="-12.3" /TU="NA" /idTUdmin="U1988" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2146449..2147492) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9434186, 11432857, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9434186, 11432857, 12060778, 12682299, 22333191, 23525462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase clamp loader delta subunit" /protein_id="NP_390434.1" /db_xref="EnsemblGenomes-Gn:BSU25560" /db_xref="EnsemblGenomes-Tr:CAB14498" /db_xref="GOA:P54459" /db_xref="InterPro:IPR005790" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR010372" /db_xref="InterPro:IPR027417" /db_xref="PDB:3ZH9" /db_xref="SubtiList:BG11642" /db_xref="UniProtKB/Swiss-Prot:P54459" /translation="MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQET KDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSAL ESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAK TEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQN IFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQK QIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLL QLLKRNEKNDPHY*" /label="holA CDS" gene complement(2146449..2147492) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /label="holA gene" downshifts complement(2146494) /Source="Nicolas_upshifts" /id="D1322" /incds=0 /nref=14 /ntot=198 /MaxReadThrough="1.76478" /MaxDrop="4.34213" /score="-1.12561483" /energy="-8.1" /TU="NA" /idTUdmin="U1989" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2147521..2147540) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2147532..2147681) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513978.1" /translation="MKNLEAKVTFSVLVIIAFLQAVPGACEQAFNINGEAAVRLPLYY FANSI*" /label="hypothetical protein CDS" gene complement(2147532..2147681) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /label="gene" upshifts complement(2147533) /Source="Nicolas_upshifts" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2147554..2147558) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2147556..2147895) /Source="Nicolas_S_feature" /locus_tag="new_2637203_2637542_c" /HighExp="S8, S6, S7, BT, S5, C30, Pyr, G/S, B36, GM 150" /AntisenseName="yqzM" /AntisenseCor="-2.0369593011890001E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S962" downshifts complement(2147599) /Source="Nicolas_upshifts" /id="D1323" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="5.04584" /MaxDrop="3.298" /score="-1.12561483" /energy="-8.1" /TU="U1991,U1995" /idTUdmin="U1992" /TUdmin=748 /isTUend="FALSE" /label="downshifts" promotor_-35 2147668..2147674 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2147688..2147707 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2147689 /Source="Nicolas_upshifts" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="upshifts" CDS 2147722..2147856 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097762.1" /db_xref="EnsemblGenomes-Gn:BSU25569" /db_xref="EnsemblGenomes-Tr:CAX52662" /db_xref="GOA:C0H453" /db_xref="InterPro:IPR025416" /db_xref="UniProtKB/Swiss-Prot:C0H453" /translation="MNDFEKNVQSKRNDAVDSAVGFVVSFGFFAFLFVMATVIHLVGS *" /label="yqzM CDS" gene 2147722..2147856 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /label="yqzM gene" downshifts 2147850 /Source="Nicolas_upshifts" /id="D1324" /incds=0 /nref=156 /ntot=250 /MaxReadThrough="3.51266" /MaxDrop="6.2258" /score="20.1810918" /energy="-12.1" /TU="U1990" /idTUdmin="U1990" /TUdmin="-465" /isTUend="FALSE" /label="downshifts" CDS complement(2147896..2150226) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12123453, 15661011, 16751195, 17630974, 21397556, 27318187" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123453, 15661011, 16751195, 17630974, 21397556, 27318187; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="DNA channel for uptake in competent cells" /protein_id="NP_390435.1" /db_xref="EnsemblGenomes-Gn:BSU25570" /db_xref="EnsemblGenomes-Tr:CAB14499" /db_xref="GOA:P39695" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004477" /db_xref="InterPro:IPR004797" /db_xref="InterPro:IPR025405" /db_xref="InterPro:IPR035681" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10482" /db_xref="UniProtKB/Swiss-Prot:P39695" /translation="MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRH AFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETP DKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHI HWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVED EVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLT GAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAV SFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFY TFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAP VLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQ GDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDA LILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRG DVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFP NIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIR VLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN*" /label="comEC CDS" gene complement(2147896..2150226) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /label="comEC gene" promotor_-10 complement(2147913..2147932) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2147929) /Source="Nicolas_upshifts" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2147946..2147955) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2150230..2150799) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /EC_number="3.5.4.12" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7768800, 26416910; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="dCMP deaminase associated to DNA transport (competence)" /protein_id="NP_390436.1" /db_xref="EnsemblGenomes-Gn:BSU25580" /db_xref="EnsemblGenomes-Tr:CAB14500" /db_xref="GOA:P32393" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR013404" /db_xref="InterPro:IPR015517" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR016473" /db_xref="InterPro:IPR035105" /db_xref="SubtiList:BG10481" /db_xref="UniProtKB/Swiss-Prot:P32393" /translation="MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYN GSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCC KSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGL IGKLADAGLAEEELKKIHEQANTLFTSYV*" /label="comEB CDS" gene complement(2150230..2150799) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /label="comEB gene" promotor_-10 complement(2150826..2150845) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2150836) /Source="Nicolas_upshifts" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2150860..2150867) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2150866..2151483) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16751195, 21278288, 22398145, 25727469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751195, 21278288, 22398145, 25727469; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane bound high-affinity DNA-binding receptor" /protein_id="NP_390437.1" /db_xref="EnsemblGenomes-Gn:BSU25590" /db_xref="EnsemblGenomes-Tr:CAB14501" /db_xref="GOA:P39694" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004509" /db_xref="InterPro:IPR004787" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR019554" /db_xref="SubtiList:BG10480" /db_xref="UniProtKB/Swiss-Prot:P39694" /translation="MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTET ENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQ VNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK*" /label="comEA CDS" gene complement(2150866..2151483) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /label="comEA gene" promotor_-35 2151504..2151509 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2151521 /Source="Nicolas_upshifts" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2151525..2151543 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2151544..2151558) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2151546) /Source="Nicolas_upshifts" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2151548..2152395) /Source="Nicolas_S_feature" /locus_tag="new_2641195_2642042_c" /HighExp="C30, T0.30H, T-2.40H, GM 150, T1.30H, T-0.40H, T-1.10H, T-1.40H, T1.0H, T0.0H" /AntisenseName="comER" /AntisenseCor="-8.2389039371154299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S963" promotor_-35 complement(2151567..2151571) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2151567..2152388 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /EC_number="1.5.1.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7968523, 11418582, 27446060, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrroline-5'-carboxylate reductase" /protein_id="NP_390438.1" /db_xref="EnsemblGenomes-Gn:BSU25600" /db_xref="EnsemblGenomes-Tr:CAB14502" /db_xref="GOA:P39696" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10479" /db_xref="UniProtKB/Swiss-Prot:P39696" /translation="MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIK NRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTE QLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESD ITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELY TLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV*" /label="comER CDS" gene 2151567..2152388 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /label="comER gene" promotor_-10 complement(2152383..2152402) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2152389..2152469 /Source="Nicolas_S_feature" /locus_tag="new_2642036_2642116" /HighExp="S4, S5, S3, S6, S7, B36, Pyr, G/S, S8, BT" /AntisenseName="yqeM" /AntisenseCor="-0.52267300854840604" /AntisenseRegPval="-19.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S964" upshifts complement(2152396) /Source="Nicolas_upshifts" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2152416..2152423) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2152429 /Source="Nicolas_upshifts" /id="D1325" /incds=0 /nref=45 /ntot=64 /MaxReadThrough="2.4803" /MaxDrop="5.1403" /score="7.09525061" /energy="-10.5" /TU="NA" /idTUdmin="U1993" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2152454..2153197) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390439.1" /db_xref="EnsemblGenomes-Gn:BSU25610" /db_xref="EnsemblGenomes-Tr:CAB14503" /db_xref="GOA:P54458" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11641" /db_xref="UniProtKB/Swiss-Prot:P54458" /translation="MIYQGFASVYDELMSHAPYDQWTKWIEASLPEKGRILDLACGTG EISIRLAEKGFEVTGIDLSEEMLSFAQQKVSSSQPILFLQQDMREITGFDGQFDAVVI CCDSLNYLKTKNDVIETFKSVFRVLKPEGILLFDVHSSFKIAEVFPDSTFADQDEDIS YIWQSFAGSDELSVIHDMSFFVWNGEAYDRFDETHEQRTFPVEEYEEMLKNCGFQLHR VTADFTDTEPSAQSERLFFKAQKSKTIVS*" /label="yqeM CDS" gene complement(2152454..2153197) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /label="yqeM gene" downshifts complement(2152484) /Source="Nicolas_upshifts" /id="D1326" /incds=0 /nref=144 /ntot=230 /MaxReadThrough="1.41467" /MaxDrop="5.51802" /score="7.9251293" /energy="-10.5" /TU="NA" /idTUdmin="U1996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2153194..2153550) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 16980477, 22238375, 22238376, 22829778, 26299947; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal silencing factor" /protein_id="NP_390440.1" /db_xref="EnsemblGenomes-Gn:BSU25620" /db_xref="EnsemblGenomes-Tr:CAB14504" /db_xref="GOA:P54457" /db_xref="InterPro:IPR004394" /db_xref="SubtiList:BG11640" /db_xref="UniProtKB/Swiss-Prot:P54457" /translation="MNQKSILKIAAAACDDKRAEDILALDMEGISLVADYFLICHGNS DKQVQAIAREIKDQADENGIQVKKMEGFDEARWVLVDLGDVVVHVFHKDERSYYNLEK LWGDAPLADLDFGMNQ*" /label="rsfS CDS" gene complement(2153194..2153550) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /label="rsfS gene" CDS complement(2153568..2154128) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390441.1" /db_xref="EnsemblGenomes-Gn:BSU25630" /db_xref="EnsemblGenomes-Tr:CAB14505" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR005249" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11639" /db_xref="UniProtKB/Swiss-Prot:P54456" /translation="MNREEALACVKQQLTEHRYIHTVGVMNTAIELAERFGADSKKAE IAAIFHDYAKFRPKEEMKQIIAREKMPAHLLDHNPELWHAPVGAYLVQREAGVQDEDI LDAIRYHTSGRPGMTLLEKVIYVADYIEPNRAFPGVDEVRKLAETDLNQALIQSIKNT MVFLMKKNQPVFPDTFLTYNWLVSGS*" /label="yqeK CDS" gene complement(2153568..2154128) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /label="yqeK gene" CDS complement(2154118..2154687) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /EC_number="2.7.7.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11704676, 12682299, 19716475, 23204464, 25631047; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide adenylyltransferase" /protein_id="NP_390442.1" /db_xref="EnsemblGenomes-Gn:BSU25640" /db_xref="EnsemblGenomes-Tr:CAB14506" /db_xref="GOA:P54455" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="PDB:1KAM" /db_xref="PDB:1KAQ" /db_xref="SubtiList:BG11638" /db_xref="UniProtKB/Swiss-Prot:P54455" /translation="MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPH KQNEDYTDSFHRVEMLKLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLF FIIGADMIEYLPKWYKLDELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIR ERFKSKKPTDYLIPDKVKKYVEENGLYES*" /label="nadD CDS" gene complement(2154118..2154687) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /label="nadD gene" CDS complement(2154699..2154989) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 17005971, 17105995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 17005971, 17105995; Product type f: factor" /codon_start=1 /transl_table=11 /product="50S RNA-binding protein" /protein_id="NP_390443.1" /db_xref="EnsemblGenomes-Gn:BSU25650" /db_xref="EnsemblGenomes-Tr:CAB14507" /db_xref="GOA:P54454" /db_xref="InterPro:IPR001890" /db_xref="InterPro:IPR017924" /db_xref="InterPro:IPR035920" /db_xref="SubtiList:BG11637" /db_xref="UniProtKB/Swiss-Prot:P54454" /translation="MLTGKQKRFLRSKAHHLTPIFQVGKGGVNDNMIKQIAEALEARE LIKVSVLQNCEEDKNDVAEALVKGSRSQLVQTIGNTIVLYKESKENKQIELP*" /label="yqeI CDS" gene complement(2154699..2154989) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /label="yqeI gene" CDS complement(2154983..2155825) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /EC_number="1.1.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2104604, 12906820, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate 5-dehydrogenase" /protein_id="NP_390444.2" /db_xref="EnsemblGenomes-Gn:BSU25660" /db_xref="EnsemblGenomes-Tr:CAB14508" /db_xref="GOA:P54374" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR011342" /db_xref="InterPro:IPR013708" /db_xref="InterPro:IPR022893" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11522" /db_xref="UniProtKB/Swiss-Prot:P54374" /translation="MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDL EDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTD GEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRL TEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCD IVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLG GTEC*" /label="aroE CDS" gene complement(2154983..2155825) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /label="aroE gene" downshifts 2155817 /Source="Nicolas_upshifts" /id="D1327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="0.240279999999999" /MaxDrop="3.04009" /score="0.0642154872" /energy="-17" /TU="NA" /idTUdmin="U1993" /TUdmin=3388 /isTUend="FALSE" /label="downshifts" CDS complement(2155843..2156943) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent GTPase involved in ribosome 30S assembly" /protein_id="NP_390445.1" /db_xref="EnsemblGenomes-Gn:BSU25670" /db_xref="EnsemblGenomes-Tr:CAB14509" /db_xref="GOA:P54453" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019988" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="SubtiList:BG11636" /db_xref="UniProtKB/Swiss-Prot:P54453" /translation="MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKN YNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVG NKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGK DVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPG IINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFIC YMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVF SGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI*" /label="rgpH CDS" gene complement(2155843..2156943) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /label="rgpH gene" CDS complement(2156947..2157465) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase (active on GMP and Glc-6-P)" /protein_id="NP_390446.1" /db_xref="EnsemblGenomes-Gn:BSU25680" /db_xref="EnsemblGenomes-Tr:CAB14510" /db_xref="GOA:P54452" /db_xref="InterPro:IPR006356" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR006549" /db_xref="InterPro:IPR010021" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11635" /db_xref="UniProtKB/Swiss-Prot:P54452" /translation="MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDR PNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRA VRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILS ALKRKGHIQWEE*" /label="yqeG CDS" gene complement(2156947..2157465) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /label="yqeG gene" promotor_-10 complement(2157375..2157392) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2157389) /Source="Nicolas_upshifts" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2157408..2157411) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2157466..2158027) /Source="Nicolas_S_feature" /locus_tag="new_2647113_2647674_c" /HighExp="G135, G180, G150, Paraq, Oxctl, C30, Heat, HPh, BMM, LPh" /AntisenseName="sda" /AntisenseCor="-8.6107693225382295E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S965" downshifts complement(2157499) /Source="Nicolas_upshifts" /id="D1328" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="6.83118" /MaxDrop="5.26138" /score="9.20556883" /energy="-8.6" /TU="U1998" /idTUdmin="U1999" /TUdmin=616 /isTUend="FALSE" /label="downshifts" promotor_-35 2157690..2157697 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2157708..2157808 /Source="Nicolas_S_feature" /locus_tag="new_2647355_2647455" /HighExp="T3.0H, T-0.40H, MG 150, T5.0H, T-1.40H, T4.0H, T2.30H, T0.0H, T3.30H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S966" promotor_-10 2157708..2157727 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2157708 /Source="Nicolas_upshifts" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(2157758..2158016) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /product="antisense RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sdaM RNA" gene complement(2157758..2158016) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /label="sdaM gene" CDS 2157809..2157967 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15023339, 16796683, 19040634, 22720735, 28752667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023339, 16796683, 19040634, 22720735, 28752667; Product type f: factor" /codon_start=1 /transl_table=11 /product="check point factor coupling initiation of sporulation and replication initiation" /protein_id="YP_054588.1" /db_xref="EnsemblGenomes-Gn:BSU25690" /db_xref="EnsemblGenomes-Tr:CAE01463" /db_xref="GOA:Q7WY62" /db_xref="InterPro:IPR015064" /db_xref="InterPro:IPR036916" /db_xref="PDB:1PV0" /db_xref="PDB:3FYR" /db_xref="SubtiList:BG14183" /db_xref="UniProtKB/Swiss-Prot:Q7WY62" /translation="MNWVPSMRKLSDELLIESYFKATEMNLNRDFIELIENEIKRRSL GHIISVSS*" /label="sda CDS" gene 2157809..2157967 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /label="sda gene" S_feature 2157968..2158214 /Source="Nicolas_S_feature" /locus_tag="new_2647615_2647861" /HighExp="Cold, T-0.40H, MG 150, T5.0H, T4.0H, C30, T2.30H, M9-tran, S2, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S967" promotor_-10 complement(2158015..2158034) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2158026) /Source="Nicolas_upshifts" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2158050..2158054) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2158078..2158225) /Source="Nicolas_S_feature" /locus_tag="new_2647725_2647872_c" /HighExp="S8, S7, S6, Etha, LBGstat, T0.30H, Salt, BT, LPhT, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99948400000000004" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S968" downshifts complement(2158115) /Source="Nicolas_upshifts" /id="D1329" /incds=0 /nref=12 /ntot=92 /MaxReadThrough="2.70676" /MaxDrop="4.386" /score="9.20556883" /energy="-8.6" /TU="NA" /idTUdmin="U1999" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2158171 /Source="Nicolas_upshifts" /id="D1330" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="5.36291" /MaxDrop="2.1106" /score="10.3636587" /energy="-6.2" /TU="U1997" /idTUdmin="U1997" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 2158216..>2158293 /Source="Nicolas_S_feature" /locus_tag="new_2647863_2648916" /HighExp="T-0.40H, Cold, M40t90, T0.0H, C30, Glucon, S2, T1.30H, T2.30H, T2.0H" /AntisenseName="yqeF" /AntisenseCor="-0.39616310996746001" /AntisenseRegPval="-10.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S969" promotor_-10 complement(2158220..2158239) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2158225) /Source="Nicolas_upshifts" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2158252..2158261) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2158293,2158295) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_003" N_region 2158294 /note="inserted C residue" /created_by="User" /modified_by="User" /label="IIG_Bs27_003" S_feature <2158295..2158737 /Source="Nicolas_S_feature" /locus_tag="new_2701783_2703117" /HighExp="S8, S6, S7, S5, S4, BT, B36, dia15, C30, H2O2" /AntisenseName="psiE" /AntisenseCor="0.376363934894826" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="0.117191" /TUshortSig="Sig-" /TUshortPSig="0.218" /TUlongSig="NA" /TUlongPSig="NA" /label="S984" CDS complement(2158308..2158724) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12897016, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="phosphate starvation inducible protein" /protein_id="NP_390518.2" /db_xref="EnsemblGenomes-Gn:BSU26410" /db_xref="EnsemblGenomes-Tr:CAB14582" /db_xref="GOA:P54445" /db_xref="InterPro:IPR009315" /db_xref="InterPro:IPR020948" /db_xref="SubtiList:BG11784" /db_xref="UniProtKB/Swiss-Prot:P54445" /translation="MRFSNKFKKVPYLLQALLNVCLFFLALALSALLISETWYIVLFV YKSLFNKVDSYYEMLGELLIFFMYFEFIALIIKYFKSDFHFPLRYFIYIGITAVIRLI IIDHDQAISTFWWAMAILAMICGFFIANRRNSVVEH*" /label="psiE CDS" gene complement(2158308..2158724) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /label="psiE gene" CDS complement(2158770..2160068) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YrkP]" /protein_id="NP_390519.1" /db_xref="EnsemblGenomes-Gn:BSU26420" /db_xref="EnsemblGenomes-Tr:CAB14583" /db_xref="GOA:P54444" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11783" /db_xref="UniProtKB/Swiss-Prot:P54444" /translation="MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSS EEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIY SESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLI IVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKL KAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKAL QLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPE TYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPE SNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM*" /label="yrkQ CDS" gene complement(2158770..2160068) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /label="yrkQ gene" CDS complement(2160055..2160750) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18175906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18175906; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YrkQ]" /protein_id="NP_390520.1" /db_xref="EnsemblGenomes-Gn:BSU26430" /db_xref="EnsemblGenomes-Tr:CAB14584" /db_xref="GOA:P54443" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11782" /db_xref="UniProtKB/Swiss-Prot:P54443" /translation="MAYRILVVEDDEDIGDLLEESLTRAGYEVLRAKDGKRALQLVND SLDLVILDIMMPGISGIETCQHIRKSSNVPILFLTARSSTLDKTEGLLAGGDDYMTKP FSEEELHARVIAQLRRYTIYQEKKEQEETFLIGGKLRVSEEFNEVWKEEKQIKLSDLE YRILKLLMNKRNKIFSAQNIYESVWGQPYFYCSNNTVMVHIRKLRSKIEDDPARPVYI KTEWGRGYRFGAS*" /label="yrkP CDS" gene complement(2160055..2160750) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /label="yrkP gene" misc_feature complement(2160816..2160833) /Source="Nicolas_upshift_promotors" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2160825) /Source="Nicolas_upshifts" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2160911..2160917 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2160924..2160942 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2160939 /Source="Nicolas_upshifts" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2161018..2162235 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390521.1" /db_xref="EnsemblGenomes-Gn:BSU26440" /db_xref="EnsemblGenomes-Tr:CAB14585" /db_xref="GOA:P54442" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11781" /db_xref="UniProtKB/Swiss-Prot:P54442" /translation="MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSV KGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLS ILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFT MLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMF LLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISS VLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFL RYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSP KATPLHSEKSIQK*" /label="yrkO CDS" gene 2161018..2162235 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /label="yrkO gene" promotor_-35 2161477..2161484 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2161499..2161518 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2161515 /Source="Nicolas_upshifts" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2162154..2162402 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513983.1" /translation="MAQADVRQSKRESQSNSAAFGKIYSEITPLHRLHDFKLVLLNEA GIKRTDLIYGLVIFISFRLLWANKSTRVYSMCIAHDRI*" /label="hypothetical protein CDS" gene 2162154..2162402 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /label="gene" S_feature complement(2162331..2163378) /Source="Nicolas_S_feature" /locus_tag="new_2706711_2707758_c" /HighExp="Diami, C30, dia15, dia5, Lbstat, S8, C90, G180, H2O2, G135" /AntisenseName="yrkN" /AntisenseCor="0.40539464433869998" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S985" CDS 2162747..2163304 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /EC_number="2.3.-.-" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390522.1" /db_xref="EnsemblGenomes-Gn:BSU26450" /db_xref="EnsemblGenomes-Tr:CAB14586" /db_xref="GOA:P54441" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11780" /db_xref="UniProtKB/Swiss-Prot:P54441" /translation="MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDG PIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQG IGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRN GREDDKPLLNDDDFFRFVKIMKKKD*" /label="yrkN CDS" gene 2162747..2163304 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /label="yrkN gene" S_feature 2163305..2163427 /Source="Nicolas_S_feature" /locus_tag="new_2707685_2707807" /HighExp="S8, Sw, C30, S7, BC, C90, Lbstat, Mal, LoTm, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S986" S_feature complement(2163380..2163794) /Source="Nicolas_S_feature" /locus_tag="new_2707760_2708174_c" /HighExp="M0t90, M40t90, Lbstat, dia5, LPhT, dia15, M9-stat, Lbtran, C90, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S987" downshifts complement(2163423) /Source="Nicolas_upshifts" /id="D1360" /incds=0 /nref=81 /ntot=255 /MaxReadThrough="5.45539" /MaxDrop="5.6563" /score="-3.35079978" /energy="-23.7" /TU="U2041,U2042,U2044,U2045" /idTUdmin="U2042" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" CDS complement(2163795..2164319) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /EC_number="1.6.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase" /protein_id="NP_390524.2" /db_xref="EnsemblGenomes-Gn:BSU26470" /db_xref="EnsemblGenomes-Tr:CAB14588" /db_xref="GOA:P54439" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11778" /db_xref="UniProtKB/Swiss-Prot:P54439" /translation="MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFI IDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELL LAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVK NSAERLVDYLKAEH*" /label="yrkL CDS" gene complement(2163795..2164319) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /label="yrkL gene" promotor_-35 2164167..2164174 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2164185..2164204 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2164199 /Source="Nicolas_upshifts" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2164320..2164407) /Source="Nicolas_S_feature" /locus_tag="new_2708700_2708787_c" /HighExp="dia5, Etha, dia15, M9-stat, M0t90, Lbtran, Diami, C90, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S988" promotor_-10 complement(2164402..2164421) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2164407) /Source="Nicolas_upshifts" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2164409..>2164545) /Source="Nicolas_S_feature" /locus_tag="new_2708789_2708942_c" /HighExp="M0t90, M9-stat, Lbstat, M40t90, T1.30H, C90, Lbtran, T0.30H, dia15, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S989" promotor_-35 complement(2164436..2164443) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2164545,2164552) /created_by="User" /note="deletion occured in betwen marked nucleotides " /modified_by="User" /label="IIG_Bs12" N_region 2164546..2164551 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs12" CDS complement(2164604..2165134) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11700344, 15019740, 17675383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11700344, 15019740, 17675383; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z)" /protein_id="NP_390561.1" /db_xref="EnsemblGenomes-Gn:BSU26840" /db_xref="EnsemblGenomes-Tr:CAB14625" /db_xref="GOA:O05409" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014304" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11976" /db_xref="UniProtKB/Swiss-Prot:O05409" /translation="MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLP NLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRS TIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHI EADRYGNIVDFRILKE*" /label="sigZ CDS" gene complement(2164604..2165134) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /label="sigZ gene" promotor_-10 complement(2165180..2165199) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2165203) /Source="Nicolas_upshifts" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2165213..2165220) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2165269..2166249 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23990306, 25326299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_390562.2" /db_xref="EnsemblGenomes-Gn:BSU26850" /db_xref="EnsemblGenomes-Tr:CAB14626" /db_xref="GOA:O05408" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG12309" /db_xref="UniProtKB/Swiss-Prot:O05408" /translation="MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGI QFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRG LSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSS NFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLA GGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPV LTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW*" /label="yrpG CDS" gene 2165269..2166249 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /label="yrpG gene" CDS complement(2166523..2167839) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053381, 11566984, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative citrate transporter" /protein_id="NP_390563.1" /db_xref="EnsemblGenomes-Gn:BSU26860" /db_xref="EnsemblGenomes-Tr:CAB14627" /db_xref="GOA:O05407" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG12279" /db_xref="UniProtKB/Swiss-Prot:O05407" /translation="MLTILGFSMVTVFTILIMTKKVSPIVALTITPIVFALIGGFGKG IGDMILEGIQTVASSAALLLFAILFFGILIDAGLFDPLIEKILSIVKGDPVKIAIGSA VLAMLIALDGDGTTTYMITVSAMLPLYKRIGMNPMVMATLAMLSLSIVSGMTPWGGPA TRAISVLGLDPSDFFVPLLPTMLGGIACVIFLAFLMGRKERNRIGIVQLEPRHITKDS SQSYMAATLESEQLKRPRLIYLNLFLVISIMVFIVLGTKHPSVLFLIGFVLALTINYP NVKMQKERIAEHSGNAITVVLLVFSAGVFAGILSGTKMVDAIAGSLISIIPSSMGGFF PVIVALTSIPFTFVLSNDAYYFGMVPIFAEAASAYGIEPVEIARASIMGQPVHLMSPL VASTVLLVSMLKMDLGSFQRFAVKWAVITSLVITLLAIITGAITIL*" /label="yraO CDS" gene complement(2166523..2167839) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /label="yraO gene" S_feature complement(2167840..2167953) /Source="Nicolas_S_feature" /locus_tag="new_2745480_2745593_c" /HighExp="Lbtran, M40t90, Lbstat, HiTm, Mal, Gly, M0t90, S1, T1.0H, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1012" CDS complement(2167954..2168823) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (probes citrate or citrate-related metabolite)" /protein_id="NP_390564.1" /db_xref="EnsemblGenomes-Gn:BSU26870" /db_xref="EnsemblGenomes-Tr:CAB14628" /db_xref="GOA:O07906" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12278" /db_xref="UniProtKB/Swiss-Prot:O07906" /translation="MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFG IELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFA QYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLT REKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQET CKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKA FIDFLKGEQMVTI*" /label="yraN CDS" gene complement(2167954..2168823) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /label="yraN gene" promotor_-10 complement(2168846..2168865) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2168863) /Source="Nicolas_upshifts" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2168880..2168885) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2168930..2168931) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2168938) /Source="Nicolas_upshifts" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2168968..2168969) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2168968..2170071 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /EC_number="5.3.3.7" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11294638, 12473114, 14702315, 17567742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate isomerase" /protein_id="NP_390565.2" /db_xref="EnsemblGenomes-Gn:BSU26880" /db_xref="EnsemblGenomes-Tr:CAB14629" /db_xref="GOA:O07931" /db_xref="InterPro:IPR007400" /db_xref="SubtiList:BG12277" /db_xref="UniProtKB/Swiss-Prot:O07931" /translation="MVKTNVTIMRGGTSKGVFFHESAMPNNKNEWEPFLLDVMGSPDK RQIDGLGGGNSLTSKVAIIKKAYTSDIDVHYTFGQVSISEEKVDFKGNCGNISAAVGP FAIEEGLVKAKEPMTAVRILNTNTNKMIIAEVEVEDGQVKYDGDVTISGVPGSGSPIY LNFHDAAGSVTGHLLPTGNSSEFLDTSQGQIEVSIIDYANPLVFVEASSIGLDGTELA EEFTDLQLAQFEELRSIAAEKCGFASRFSATKLSPAVPKLAIVAKPEKYKDSTGAWHS SVEMDLHIRMMSMQKPHQALAVTGAICTTRALSVEGAIPARIAKNHSTKVRLAHSSGI IETMVEPTGIKIVRTARRIMDGTVYTHGDYQMM*" /label="prpF CDS" gene 2168968..2170071 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /label="prpF gene" misc_feature 2169961..2169980 /Source="Nicolas_upshift_promotors" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2169967 /Source="Nicolas_upshifts" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2170318) /Source="Nicolas_upshifts" /id="D1374" /incds=0 /nref=123 /ntot=254 /MaxReadThrough="2.33762" /MaxDrop="7.47213" /score="6.31571576" /energy="-8.7" /TU="U2071" /idTUdmin="U2071" /TUdmin="-33" /isTUend="FALSE" /label="downshifts" CDS complement(2170344..2171177) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /EC_number="3.2.1.132" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11065371, 11320136, 1664582, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11065371, 11320136, 1664582, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chitosanase" /protein_id="NP_390566.1" /db_xref="EnsemblGenomes-Gn:BSU26890" /db_xref="EnsemblGenomes-Tr:CAB14630" /db_xref="GOA:O07921" /db_xref="InterPro:IPR000400" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11923" /db_xref="UniProtKB/Swiss-Prot:O07921" /translation="MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKR RAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNN KLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKR SDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNK FLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVI K*" /label="csn CDS" gene complement(2170344..2171177) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /label="csn gene" misc_feature complement(2171207..2171226) /Source="Nicolas_upshift_promotors" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2171216) /Source="Nicolas_upshifts" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2171382..2171386 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2171397..2171619 /Source="Nicolas_S_feature" /locus_tag="new_2749037_2749259" /HighExp="Lbstat, M9-stat, B60, M0t90, M40t90, T1.30H, T2.0H, T3.0H, T2.30H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97565800000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1013" upshifts 2171397 /Source="Nicolas_upshifts" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2171401..2171420 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2171620..2171883 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390567.1" /db_xref="EnsemblGenomes-Gn:BSU26900" /db_xref="EnsemblGenomes-Tr:CAB14631" /db_xref="GOA:O07917" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12276" /db_xref="UniProtKB/Swiss-Prot:O07917" /translation="MAYVKATAILPEKLISEIQKYVQGKTIYIPKPESSHQKWGACSG TRKLIDDRNASIKKAFKNGKTIHQLSDEYHLSIETIKKIVYSK*" /label="yraL CDS" gene 2171620..2171883 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /label="yraL gene" downshifts 2171871 /Source="Nicolas_upshifts" /id="D1375" /incds=0 /nref=71 /ntot=223 /MaxReadThrough="1.7419" /MaxDrop="4.94534" /score="-1.04752822" /energy="-9.9" /TU="NA" /idTUdmin="U2072" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS 2172020..2172835 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390568.2" /db_xref="EnsemblGenomes-Gn:BSU26910" /db_xref="EnsemblGenomes-Tr:CAB14632" /db_xref="GOA:O07937" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12275" /db_xref="UniProtKB/Swiss-Prot:O07937" /translation="MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVAN HLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGA VIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRL ETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSAS RELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC*" /label="yraK CDS" gene 2172020..2172835 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /label="yraK gene" S_feature complement(2173170..2173242) /Source="Nicolas_S_feature" /locus_tag="new_2750810_2750882_c" /HighExp="BC, Lbstat, Sw, M40t90, M0t90, S2, BI, BT, S3, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1014" downshifts complement(2173213) /Source="Nicolas_upshifts" /id="D1376" /incds=0 /nref=44 /ntot=205 /MaxReadThrough="1.43644" /MaxDrop="4.78753" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2073" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2173243..2173599) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390569.2" /db_xref="EnsemblGenomes-Gn:BSU26920" /db_xref="EnsemblGenomes-Tr:CAB14633" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12274" /db_xref="UniProtKB/Swiss-Prot:O07934" /translation="MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRS GPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSD TYVYTGSDGPVGYKCN*" /label="yraJ CDS" gene complement(2173243..2173599) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /label="yraJ gene" CDS complement(2173652..2174011) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390570.2" /db_xref="EnsemblGenomes-Gn:BSU26930" /db_xref="EnsemblGenomes-Tr:CAB14634" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12273" /db_xref="UniProtKB/Swiss-Prot:O07909" /translation="MNKLKRLSMLTVMIASVFIFSSHALAAQYYTVSTSSGAPVNMRS GPGTSWGIVTTIPSGTRIPIYCYKTGTTVTGKYGTSNIWNYTERTLASGEIVPGFVSD TYMYTGSDGPVVPKCSW*" /label="yraI CDS" gene complement(2173652..2174011) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /label="yraI gene" misc_feature complement(2174104..2174123) /Source="Nicolas_upshift_promotors" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2174114) /Source="Nicolas_upshifts" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2174283..2174384) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513987.1" /translation="MIGEKGGVSMNREEAWIQGSSTLIELIGGNEAA*" /label="hypothetical protein CDS" gene complement(2174283..2174384) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /label="gene" S_feature complement(2174424..2174526) /Source="Nicolas_S_feature" /locus_tag="new_2752064_2752166_c" /HighExp="M40t90, LBGstat, M40t45, M0t90, Lbstat, Lbtran, LBGtran, LPhT, ferm, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.575" /TUlongSig="NA" /TUlongPSig="NA" /label="S1015" downshifts complement(2174466) /Source="Nicolas_upshifts" /id="D1377" /incds=0 /nref=19 /ntot=188 /MaxReadThrough="2.12056" /MaxDrop="4.09264" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2074" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2174527..2174913) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390571.1" /db_xref="EnsemblGenomes-Gn:BSU26940" /db_xref="EnsemblGenomes-Tr:CAB14635" /db_xref="GOA:O07918" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12272" /db_xref="UniProtKB/Swiss-Prot:O07918" /translation="MKLLQIRLLVNDFKKSVEFYKDSLGLPISWLENEMEYALFDNGE TKIELLSRETMAEIVGEEKKSLEGEAQSKFLLQFKVEDVDKTYDDLHEKGVKCENKPH DRKEWSARVAHFRDPDHNLIEIYKML*" /label="yraH CDS" gene complement(2174527..2174913) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /label="yraH gene" misc_feature complement(2174955..2174971) /Source="Nicolas_upshift_promotors" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2174971) /Source="Nicolas_upshifts" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2175104..2175110 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2175125..2175136 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2175125 /Source="Nicolas_upshifts" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="upshifts" CDS 2175162..2175407 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390572.1" /db_xref="EnsemblGenomes-Gn:BSU26950" /db_xref="EnsemblGenomes-Tr:CAB14636" /db_xref="GOA:O07919" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG12271" /db_xref="UniProtKB/Swiss-Prot:O07919" /translation="MDHQTLAAHEAVDLHEIVNFKTLCIAKSKLMQGLVFDQELKDLM EKDVQQSIQDLTELQAVYERASFQAPVPQSRPTPIIN*" /label="yraG CDS" gene 2175162..2175407 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /label="yraG gene" CDS 2175425..2175793 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390573.1" /db_xref="EnsemblGenomes-Gn:BSU26960" /db_xref="EnsemblGenomes-Tr:CAB14637" /db_xref="GOA:O07949" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG12270" /db_xref="UniProtKB/Swiss-Prot:O07949" /translation="MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTET ASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNM NLFPDETNRKGMFDRTPDEH*" /label="yraF CDS" gene 2175425..2175793 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /label="yraF gene" CDS 2175812..2176948 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7926692, 17586670; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (involving bacillithiol)" /protein_id="NP_390574.2" /db_xref="EnsemblGenomes-Gn:BSU26970" /db_xref="EnsemblGenomes-Tr:CAB14638" /db_xref="GOA:O06012" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR027399" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11902" /db_xref="UniProtKB/Swiss-Prot:O06012" /translation="MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHL IHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLES QCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVI ADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQH AKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGG TMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMF ELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP*" /label="adhB CDS" gene 2175812..2176948 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /label="adhB gene" CDS 2176967..2177164 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390575.1" /db_xref="EnsemblGenomes-Gn:BSU26980" /db_xref="EnsemblGenomes-Tr:CAB14639" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13780" /db_xref="UniProtKB/Swiss-Prot:O06011" /translation="MEYALHEVLEVQEMTAFKTLCLTKSKTMKALVSDPKLKEIMQQD VDITTRQLQEFASILSNAKQE*" /label="yraE CDS" gene 2176967..2177164 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /label="yraE gene" CDS 2177180..2177479 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390576.1" /db_xref="EnsemblGenomes-Gn:BSU26990" /db_xref="EnsemblGenomes-Tr:CAB14640" /db_xref="GOA:O06010" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG13779" /db_xref="UniProtKB/Swiss-Prot:O06010" /translation="MNPIIEYLTGMNVLTDQIIAMDLLISAKNGVRNYAMAATEAGTP EVKEVLIRHLEEALDMHEQLSSYMMEKGWYHPWNPDEQVKLNLKNIDTAIQLPTL*" /label="yraD CDS" gene 2177180..2177479 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /label="yraD gene" downshifts 2177470 /Source="Nicolas_upshifts" /id="D1378" /incds=0 /nref=11 /ntot=39 /MaxReadThrough="1.62449" /MaxDrop="3.8153" /score="-8.57687054" /energy="-10.7" /TU="NA" /idTUdmin="U2075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2177742..2178164) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 17962296, 19170879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 17962296, 19170879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulated by thiol-alkylation" /protein_id="NP_390578.2" /db_xref="EnsemblGenomes-Gn:BSU27000" /db_xref="EnsemblGenomes-Tr:CAB14642" /db_xref="GOA:O06008" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13777" /db_xref="UniProtKB/Swiss-Prot:O06008" /translation="MNIAQVAKQFGLTAATLRYYERVGLIPPVKRKDSGIRDYDEEDI KWIEFIKCMRNAGLSIEALIEYTTLFTEGDRTVEARKNILADERQRLIEKRKEIDETI KRLDTKIKDYDGKLRENEAKLKSRPKTESLHGSVEQRR*" /label="adhR CDS" gene complement(2177742..2178164) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /label="adhR gene" promotor_-35 2178162..2178165 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-35" promotor_-10 2178181..2178200 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-10" S_feature 2178196..2178346 /Source="Nicolas_S_feature" /locus_tag="new_2755836_2755986" /HighExp="Diami, dia15, dia5, H2O2, S8, Paraq, S5, G180, S6, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1016" upshifts 2178196 /Source="Nicolas_upshifts" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="upshifts" promotor_-10 complement(2178199..2178218) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2178206) /Source="Nicolas_upshifts" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2178232..2178239) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2178315..2178334) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-10" upshifts complement(2178323) /Source="Nicolas_upshifts" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="upshifts" CDS 2178347..2178541 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /EC_number="4.1.1.44" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17962296, 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxymuconolactone decarboxylase" /protein_id="YP_009513988.1" /db_xref="EnsemblGenomes-Gn:BSU27009" /db_xref="EnsemblGenomes-Tr:CAX52671" /db_xref="InterPro:IPR029032" /db_xref="UniProtKB/TrEMBL:C0H460" /translation="MANKHTAGREQLGEFAPKFAELHDDVLFGDIWAREEELSSRDRS MITVSALITDCFSAYKSGSF*" /label="yrzP CDS" gene 2178347..2178541 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /label="yrzP gene" promotor_-35 complement(2178349..2178356) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-35" promotor_-35 2178559..2178566 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-35" promotor_-10 2178582..2178601 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-10" upshifts 2178586 /Source="Nicolas_upshifts" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="upshifts" S_feature 2178587..2178671 /Source="Nicolas_S_feature" /locus_tag="new_2756227_2756311" /HighExp="LBGstat, dia15, Diami, LPhT, LBGtran, dia5, M40t90, Lbtran, H2O2, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.987, 0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1017" CDS 2178672..2179721 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase; carbonyl stressresponse" /protein_id="NP_390579.2" /db_xref="EnsemblGenomes-Gn:BSU27010" /db_xref="EnsemblGenomes-Tr:CAB14643" /db_xref="GOA:C0SPA5" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12562" /db_xref="UniProtKB/Swiss-Prot:C0SPA5" /translation="MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGIC HSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEY CLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEAL ELGANHYFATSDPATFTALAGRFDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKP DTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEVIGADQVDEAYERIL RSDVRYRFVIDISTL*" /label="adhA CDS" gene 2178672..2179721 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /label="adhA gene" promotor_-35 2179789..2179796 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2179811..2179830 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2179824 /Source="Nicolas_upshifts" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="upshifts" CDS 2179852..2180361 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12775685, 17257049, 17933887, 24330391, 26774339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deglycase; general stress protecting enzyme; protects against methylglyoxal toxicity" /protein_id="NP_390580.2" /db_xref="EnsemblGenomes-Gn:BSU27020" /db_xref="EnsemblGenomes-Tr:CAB14644" /db_xref="GOA:O06006" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13776" /db_xref="UniProtKB/Swiss-Prot:O06006" /translation="MSKKIAVLVTDQFEDIEYTSPVKAYEEAGYSVVAIDLEAGKEVT GKHGEKVKIDKAISDVDASDFDALLIPGGFSPDLLRADDRPGEFAKAFVENKKPVFAI CHGPQVLIDTDLLKGKDITGYRSIRKDLINAGANYKDAEVVVSHNIVTSRTPDDLEAF NRESLNLLK*" /label="sufL CDS" gene 2179852..2180361 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /label="sufL gene" downshifts 2180330 /Source="Nicolas_upshifts" /id="D1379" /incds=0 /nref=178 /ntot=254 /MaxReadThrough="4.08169" /MaxDrop="5.1444" /score="24.8267602" /energy="-16.3" /TU="U2080" /idTUdmin="U2076" /TUdmin=528 /isTUend="FALSE" /label="downshifts" S_feature 2180375..2181480 /Source="Nicolas_S_feature" /locus_tag="new_2758015_2759120" /HighExp="Diami, dia5, Etha, dia15, LPhT, H2O2, Lbstat, Salt, Fru, Paraq" /AntisenseName="sacC" /AntisenseCor="0.18236909579254801" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.926" /label="S1018" CDS complement(2180403..2182436) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /EC_number="3.2.1.7" /EC_number="3.2.1.65" /EC_number="3.2.1.80" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7646030, 8057358, 10217495, 12224641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7646030, 8057358, 10217495, 12224641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levanase" /protein_id="NP_390581.1" /db_xref="EnsemblGenomes-Gn:BSU27030" /db_xref="EnsemblGenomes-Tr:CAB14645" /db_xref="GOA:P05656" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="PDB:4AZZ" /db_xref="PDB:4B1L" /db_xref="PDB:4B1M" /db_xref="SubtiList:BG10320" /db_xref="UniProtKB/Swiss-Prot:P05656" /translation="MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEA NWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKG TIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNP VIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSH GGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPP NKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPREL KLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKV SPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKP VNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHP LKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITI KDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNK KYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES*" /label="sacC CDS" gene complement(2180403..2182436) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /label="sacC gene" downshifts complement(2180428) /Source="Nicolas_upshifts" /id="D1380" /incds=0 /nref=14 /ntot=60 /MaxReadThrough="0.56875" /MaxDrop="5.09923" /score="-2.07442916" /energy="-14.2" /TU="NA" /idTUdmin="U2081" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2182345..2182512) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513989.1" /translation="MPETDQLAQQSLLKVFKHEERSEGTNEKETDSSHDHVHPAVDYG IFGRCSRFKLL*" /label="hypothetical protein CDS" gene complement(2182345..2182512) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /label="gene" S_feature complement(2182437..2182592) /Source="Nicolas_S_feature" /locus_tag="new_2760077_2760232_c" /HighExp="UNK1, Fru, B60, T0.30H, M40t90, M0t90, ferm, LPh, GM-0.2, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.886" /TUlongSig="NA" /TUlongPSig="NA" /label="S1019" CDS complement(2182593..2183420) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IID component" /protein_id="NP_390582.1" /db_xref="EnsemblGenomes-Gn:BSU27040" /db_xref="EnsemblGenomes-Tr:CAB14646" /db_xref="GOA:P26382" /db_xref="InterPro:IPR004704" /db_xref="SubtiList:BG10319" /db_xref="UniProtKB/Swiss-Prot:P26382" /translation="MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAI KKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKI GLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLK YGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGK VDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA* " /label="levG CDS" gene complement(2182593..2183420) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /label="levG gene" CDS complement(2183441..2184250) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIC component" /protein_id="NP_390583.1" /db_xref="EnsemblGenomes-Gn:BSU27050" /db_xref="EnsemblGenomes-Tr:CAB14647" /db_xref="GOA:P26381" /db_xref="InterPro:IPR004700" /db_xref="SubtiList:BG10318" /db_xref="UniProtKB/Swiss-Prot:P26381" /translation="MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDL KTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAA AGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALIS VSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTD FNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA*" /label="levF CDS" gene complement(2183441..2184250) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /label="levF gene" CDS complement(2184267..2184755) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /EC_number="2.7.1.202" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 9622354, 10589728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 9622354, 10589728; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIB component" /protein_id="NP_390584.1" /db_xref="EnsemblGenomes-Gn:BSU27060" /db_xref="EnsemblGenomes-Tr:CAB14648" /db_xref="GOA:P26380" /db_xref="InterPro:IPR004720" /db_xref="InterPro:IPR018455" /db_xref="InterPro:IPR036667" /db_xref="PDB:1BLE" /db_xref="SubtiList:BG10317" /db_xref="UniProtKB/Swiss-Prot:P26380" /translation="MNIVLARIDDRFIHGQILTRWIKVHAADRIIVVSDDIAQDEMRK TLILSVAPSNVKASAVSVSKMAKAFHSPRYEGVTAMLLFENPSDIVSLIEAGVPIKTV NVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDFVQILRNV TK*" /label="levE CDS" gene complement(2184267..2184755) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /label="levE gene" CDS complement(2184755..2185195) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /EC_number="2.7.1.202" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIA component" /protein_id="NP_390585.1" /db_xref="EnsemblGenomes-Gn:BSU27070" /db_xref="EnsemblGenomes-Tr:CAB14649" /db_xref="GOA:P26379" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR013789" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10316" /db_xref="UniProtKB/Swiss-Prot:P26379" /translation="MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTL QEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFIAEDQRMDMAAGVNLPILLEVLS LREHLALKDLLNNLKAMSQQSFQVCSEHLEKVKTANQDTREDEL*" /label="levD CDS" gene complement(2184755..2185195) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /label="levD gene" downshifts 2185192 /Source="Nicolas_upshifts" /id="D1381" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="0.496260000000001" /MaxDrop="4.58461" /score="24.8267602" /energy="-16.3" /TU="NA" /idTUdmin="U2080" /TUdmin=3740 /isTUend="FALSE" /label="downshifts" misc_feature complement(2185232..2185250) /Source="Nicolas_upshift_promotors" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2185236) /Source="Nicolas_upshifts" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2185385..2188192) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NifA/NtrC family)" /protein_id="NP_390586.2" /db_xref="EnsemblGenomes-Gn:BSU27080" /db_xref="EnsemblGenomes-Tr:CAB14650" /db_xref="GOA:P23914" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10677" /db_xref="UniProtKB/Swiss-Prot:P23914" /translation="MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSN VSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQN HQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQ FAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGG ILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKT FLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFG NVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEY VNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLH VRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFL KRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSI KSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEK MKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLN LHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTP IHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAI TKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFN NAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRI SDDEKLFIAAIFAEEVHGQLF*" /label="levR CDS" gene complement(2185385..2188192) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /label="levR gene" misc_feature complement(2188408..2188427) /Source="Nicolas_upshift_promotors" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2188414) /Source="Nicolas_upshifts" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="upshifts" CDS 2188739..2188879 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513990.1" /translation="MTFLFYSAIQVESRVKNRATRHVTALKIVLKFKNKSIYSFKCYN IR*" /label="hypothetical protein CDS" gene 2188739..2188879 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /label="gene" misc_feature 2188860..2188879 /Source="Nicolas_upshift_promotors" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2188870 /Source="Nicolas_upshifts" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="upshifts" CDS 2188918..2190306 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17608695, 22084243; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small amino acid permease" /protein_id="NP_390587.2" /db_xref="EnsemblGenomes-Gn:BSU27090" /db_xref="EnsemblGenomes-Tr:CAB14651" /db_xref="GOA:O06005" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12556" /db_xref="UniProtKB/Swiss-Prot:O06005" /translation="MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGK SIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGW TYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFW FALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVV FAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNE SPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKL TSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYR KTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIIL YKVQTRRGHKVK*" /label="aapA CDS" gene 2188918..2190306 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /label="aapA gene" downshifts 2190295 /Source="Nicolas_upshifts" /id="D1382" /incds=0 /nref=7 /ntot=120 /MaxReadThrough="0.96985" /MaxDrop="3.54068" /score="11.8049306" /energy="-13" /TU="NA" /idTUdmin="U2083" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(2190328..2190401) /Source="Nicolas_S_feature" /locus_tag="new_2767968_2768041_c" /HighExp="MG 120, LBGstat, MG 150, MG 90, S0, HPh, HiOs, GM-0.1, aero, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1020" downshifts complement(2190370) /Source="Nicolas_upshifts" /id="D1383" /incds=0 /nref=11 /ntot=121 /MaxReadThrough="1.79954" /MaxDrop="4.59487" /score="37.881034" /energy="-13" /TU="NA" /idTUdmin="U2084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2190402..2191034) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16098526, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_390588.1" /db_xref="EnsemblGenomes-Gn:BSU27100" /db_xref="EnsemblGenomes-Tr:CAB14652" /db_xref="GOA:O05406" /db_xref="InterPro:IPR001123" /db_xref="InterPro:IPR004778" /db_xref="SubtiList:BG12304" /db_xref="UniProtKB/Swiss-Prot:O05406" /translation="MHSLLAYIPIAAMMVIIPGADTMLVMKNTLRYGPKAGRYNILGL ATGLSFWTVIAILGLSVVIAKSVILFTTIKYLGAAYLIYLGVKSFFAKSMFSLDDMQS QAKNMASSPKRYYKTSFMQGSLSNILNPKTVLVYVTIMPQFINLNGNINQQLIILASI LTLLAVLWFLFLVYIIDYAKKWMKNSKFQKVFQKITGIILVGFGIKTGLS*" /label="yrhP CDS" gene complement(2190402..2191034) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /label="yrhP gene" downshifts complement(2190458) /Source="Nicolas_upshifts" /id="D1384" /incds=0 /nref=4 /ntot=132 /MaxReadThrough="4.46187" /MaxDrop="3.11632" /score="37.881034" /energy="-13" /TU="U2084" /idTUdmin="U2084" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2191088..2191107) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2191099) /Source="Nicolas_upshifts" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2191113..2191119 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2191122..2191129) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2191133..2191152 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2191138 /Source="Nicolas_upshifts" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="upshifts" CDS 2191187..2192014 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator controlling amino acid export" /protein_id="NP_390589.1" /db_xref="EnsemblGenomes-Gn:BSU27110" /db_xref="EnsemblGenomes-Tr:CAB14653" /db_xref="InterPro:IPR002831" /db_xref="InterPro:IPR021586" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12303" /db_xref="UniProtKB/Swiss-Prot:O05405" /translation="MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPR SKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQ TANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIV TIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWT MHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE* " /label="yrhO CDS" gene 2191187..2192014 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /label="yrhO gene" downshifts 2192010 /Source="Nicolas_upshifts" /id="D1385" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="0.74814" /MaxDrop="5.12635" /score="6.64108595" /energy="-9.5" /TU="NA" /idTUdmin="U2085" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2192127..2192136 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2192149..2192164 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2192154 /Source="Nicolas_upshifts" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="upshifts" CDS 2192210..2192710 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 21926231, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 21926231, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V))" /protein_id="NP_390590.1" /db_xref="EnsemblGenomes-Gn:BSU27120" /db_xref="EnsemblGenomes-Tr:CAB14654" /db_xref="GOA:O05404" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11974" /db_xref="UniProtKB/Swiss-Prot:O05404" /translation="MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESI KKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYK DTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQL TKEDLS*" /label="sigV CDS" gene 2192210..2192710 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /label="sigV gene" CDS 2192710..2193567 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(V) factor" /protein_id="NP_390591.1" /db_xref="EnsemblGenomes-Gn:BSU27130" /db_xref="EnsemblGenomes-Tr:CAB14655" /db_xref="GOA:O05403" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="PDB:5JEN" /db_xref="SubtiList:BG12302" /db_xref="UniProtKB/Swiss-Prot:O05403" /translation="MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTS AAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALS GLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRR NIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPN KIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISN LLVGERYIR*" /label="rsiV CDS" gene 2192710..2193567 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /label="rsiV gene" promotor_-10 complement(2193585..2193596) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2193604) /Source="Nicolas_upshifts" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2193611..2193617) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2193678..2195582 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1521192, 15661003, 21135105, 21586574, 21856855, 21926231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1521192, 15661003, 21135105, 21586574, 21856855, 21926231; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan O-acetyltransferase" /protein_id="NP_390592.1" /db_xref="EnsemblGenomes-Gn:BSU27140" /db_xref="EnsemblGenomes-Tr:CAB14656" /db_xref="GOA:O05402" /db_xref="InterPro:IPR002656" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12301" /db_xref="UniProtKB/Swiss-Prot:O05402" /translation="MYHKTQHHRYIPGLDGLRAFAVLSVITYHLNFNWANGGFIGVDI FFVLSGYLITSILLPAYGNDINLDFRDFWVRRIRRLLPAAYLMIFSTVVWVVLFDREL LHTVRGDAISSLFYMSNWWFIFHKLSYFDSFGSPSPLKNLWSLAIEEQFYIIWPMFLV VGMYIMKSRARLAAVISLLVLCSAVMMSVLYEPGGDPSRVYYGTDTRSFELLIGCALA LVWPMKRLSSNRLPSKLKHTLHATEFLAFCILVLCVYFTDEYEPFLYRGGMLFISVTA AILIACVCHPSSFLGNLLSWRPLRWLGTRSYGIYLWHYPVIVLSTPVQEIGNPVFWHI VLKVIVTCILAELSYHFIEKPIRTQGFRSFSRRVFIHRIKEWKTTSVISKMSIGFIIF AILIFAGGLSGLAGEQKHPTKWTYSSQETNADTSQASGDKKNAAADKKHNPEQKTTDS NQGQKENKDSGQETHKKKDTQSQQLKKPADTAKEVLAIGDSVMLDISSHLRQSFSNVT IDGKVGRQMSQALELAREYKSFNQPNKAVIIELGTNGYFTNSQIEQLLQSFSKAHIYL VNTRVPRQWESKVNESLQQQAHAHQNVTLVDWHTEALQHPEYFTPDGVHLVPKGAKTL TALIVQAMKS*" /label="oatA CDS" gene 2193678..2195582 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /label="oatA gene" promotor_-35 2195663..2195669 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2195685..2195703 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2195691 /Source="Nicolas_upshifts" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="upshifts" CDS 2195716..2196006 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390593.1" /db_xref="EnsemblGenomes-Gn:BSU27150" /db_xref="EnsemblGenomes-Tr:CAB14657" /db_xref="GOA:O05401" /db_xref="InterPro:IPR025424" /db_xref="SubtiList:BG12300" /db_xref="UniProtKB/Swiss-Prot:O05401" /translation="MKGNEEHDIQKELKRYELFFKKRYKVLYTVNDFIIGAMFLVGSF FFFYDRLMSAGIWLFAIGSLLLLIRPTIRLIHDFHYRKHVEQQFKHQSSTDD*" /label="yrhK CDS" gene 2195716..2196006 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /label="yrhK gene" S_feature 2196007..2196122 /Source="Nicolas_S_feature" /locus_tag="new_2773647_2773762" /HighExp="Etha, Salt, LPhT, HiTm, G135, LBGstat, G180, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1021" promotor_-35 2196104..2196111 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2196124..2196249 /Source="Nicolas_S_feature" /locus_tag="new_2773764_2773889" /HighExp="Gly, G/S, Lbstat, C90, Pyr, LPhT, LoTm, Etha, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1022" upshifts 2196124 /Source="Nicolas_upshifts" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2196125..2196143 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2196143..2196243 /gene="surF" /locus_tag="BSU_misc_RNA_82" /product="small untranslated RNA expressed under sporulation conditions (SurF-AbrB)" /experiment="publication(s) with functional evidences, PMID:20709900, 25790031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 25790031; Product type n: RNA" /label="surF RNA" gene 2196143..2196243 /gene="surF" /locus_tag="BSU_misc_RNA_82" /label="surF gene" downshifts 2196206 /Source="Nicolas_upshifts" /id="D1386" /incds=0 /nref=7 /ntot=129 /MaxReadThrough="3.60641" /MaxDrop="5.24336" /score="25.0079309" /energy="-15.8" /TU="U2089" /idTUdmin="U2088" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(2196250..2199414) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /EC_number="1.14.14.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11574077, 12775685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077, 12775685; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP102A3" /protein_id="NP_390594.1" /db_xref="EnsemblGenomes-Gn:BSU27160" /db_xref="EnsemblGenomes-Tr:CAB14658" /db_xref="GOA:O08336" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12299" /db_xref="UniProtKB/Swiss-Prot:O08336" /translation="MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT VKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQG RQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGV SYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRF WKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAAST RSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAH LPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQV LAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKA SAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAP FRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRV ENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQ EESAVWLQKLQDQRRYVKDVWTGM*" /label="cypB CDS" gene complement(2196250..2199414) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /label="cypB gene" downshifts complement(2196266) /Source="Nicolas_upshifts" /id="D1387" /incds=0 /nref=25 /ntot=213 /MaxReadThrough="2.3596" /MaxDrop="4.0425" /score="-9.99429269" /energy="-17.6" /TU="NA" /idTUdmin="U2091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2197400..2197409 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2197423..2197442 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2197444 /Source="Nicolas_upshifts" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2199430..2200014) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11574077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for cypB" /protein_id="NP_390595.1" /db_xref="EnsemblGenomes-Gn:BSU27170" /db_xref="EnsemblGenomes-Tr:CAB14659" /db_xref="GOA:O08335" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR032551" /db_xref="SubtiList:BG12298" /db_xref="UniProtKB/Swiss-Prot:O08335" /translation="MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTI YRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALF FLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKI YQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK*" /label="bscR CDS" gene complement(2199430..2200014) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /label="bscR gene" CDS complement(2200237..2200779) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390596.1" /db_xref="EnsemblGenomes-Gn:BSU27180" /db_xref="EnsemblGenomes-Tr:CAB14660" /db_xref="GOA:O05400" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12297" /db_xref="UniProtKB/Swiss-Prot:O05400" /translation="MLENRLYKRSDFWKLFSRKYKLTKTIEHMMIDSIDIQENDRILE IGIGNGTVFKSITKKLKKGSLKSIDPSKRKVRQISRANRKNMGNGEVFHGYPEDIPFD DRTFNKVFSLHTVQSCTDIRLALREIYRVLQIDGRFYISIDTNTGEKEKTYIQLLKDQ HFRDLSVIRRASCLCIVAVK*" /label="yrhH CDS" gene complement(2200237..2200779) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /label="yrhH gene" S_feature complement(2200780..2200865) /Source="Nicolas_S_feature" /locus_tag="new_2778420_2778505_c" /HighExp="T-0.40H, Salt, T0.30H, Heat, T0.0H, Etha, T-1.10H, T-1.40H, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1023" promotor_-10 complement(2200863..2200878) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2200865) /Source="Nicolas_upshifts" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2200891..2200900) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2200934..2201150) /Source="Nicolas_S_feature" /locus_tag="new_2778574_2778790_c" /HighExp="S7, S8, S6, LPhT, BT, LBGstat, S5, B36, G/S, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99909999999999999" /TUshortSig="SigK, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1024" CDS complement(2200968..2201126) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513991.1" /translation="MMNDYQKRLPSIGHGYASMPHSFKHGYGNPFRQQRLMAMQQQRL YVFPYHWH*" /label="hypothetical protein CDS" gene complement(2200968..2201126) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /label="gene" downshifts complement(2200977) /Source="Nicolas_upshifts" /id="D1388" /incds=0 /nref=34 /ntot=184 /MaxReadThrough="3.04168" /MaxDrop="7.65849" /score="23.6695072" /energy="-11.3" /TU="U2093" /idTUdmin="U2092" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2201148..2201167) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2201150) /Source="Nicolas_upshifts" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2201152..2201282) /Source="Nicolas_S_feature" /locus_tag="new_2778792_2778922_c" /HighExp="S7, S8, LPhT, S6, LBGstat, B36, BT, S5, Cold, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.893648" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1025" promotor_-35 complement(2201181..2201190) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2201283..2201432) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390597.1" /db_xref="EnsemblGenomes-Gn:BSU27190" /db_xref="EnsemblGenomes-Tr:CAB14661" /db_xref="InterPro:IPR012655" /db_xref="SubtiList:BG13819" /db_xref="UniProtKB/Swiss-Prot:O32027" /translation="MTINLFFLTLTIKKRFKSLEEFEREQQIEQIYDEMKESQLKHLY LTNWR*" /label="yrzI CDS" gene complement(2201283..2201432) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /label="yrzI gene" downshifts 2201426 /Source="Nicolas_upshifts" /id="D1389" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="1.96539" /MaxDrop="3.70444" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=4972 /isTUend="FALSE" /label="downshifts" S_feature complement(2201433..2201523) /Source="Nicolas_S_feature" /locus_tag="new_2779073_2779163_c" /HighExp="S7, LBGstat, Cold, S6, B36, LPhT, T-0.40H, LoTm, S8, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1026" S_feature complement(2201525..2201744) /Source="Nicolas_S_feature" /locus_tag="new_2779165_2779384_c" /HighExp="B60, B36, S7, BT, LBGstat, Cold, LoTm, LPhT, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52109300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1027" downshifts complement(2201568) /Source="Nicolas_upshifts" /id="D1390" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="7.23426" /MaxDrop="3.6023" /score="11.9275075" /energy="-19.6" /TU="U2093,U2094" /idTUdmin="U2094" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" downshifts 2201690 /Source="Nicolas_upshifts" /id="D1391" /incds=0 /nref=16 /ntot=94 /MaxReadThrough="0.94778" /MaxDrop="4.28987" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=5236 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2201723..2201742) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2201744) /Source="Nicolas_upshifts" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2201746..2201821) /Source="Nicolas_S_feature" /locus_tag="new_2779386_2779461_c" /HighExp="Lbexp, dia0, dia5, G150, Cold, C30, Mt0, LBGexp, dia15, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115567" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1028" promotor_-35 complement(2201757..2201764) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2201822..2202622) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 24887098; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative formate/nitrite transporter" /protein_id="NP_390598.1" /db_xref="EnsemblGenomes-Gn:BSU27200" /db_xref="EnsemblGenomes-Tr:CAB14662" /db_xref="GOA:O05399" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG12296" /db_xref="UniProtKB/Swiss-Prot:O05399" /translation="MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYL LDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISV KELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLI SAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAG SFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS*" /label="yrhG CDS" gene complement(2201822..2202622) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /label="yrhG gene" S_feature complement(2202691..2202844) /Source="Nicolas_S_feature" /locus_tag="new_2780331_2780484_c" /HighExp="Lbexp, dia0, dia5, Cold, G150, Etha, HiOs, Salt, C90, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1029" downshifts complement(2202734) /Source="Nicolas_upshifts" /id="D1392" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="6.01922" /MaxDrop="3.7673" /score="23.461824" /energy="-25" /TU="U2094,U2095" /idTUdmin="U2095" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2202835..2202854) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-10" upshifts complement(2202844) /Source="Nicolas_upshifts" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="upshifts" promotor_-35 complement(2202869..2202875) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-35" CDS complement(2202885..2203253) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390599.1" /db_xref="EnsemblGenomes-Gn:BSU27210" /db_xref="EnsemblGenomes-Tr:CAB14663" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12295" /db_xref="UniProtKB/Swiss-Prot:O05398" /translation="MSKKIHEFNDIIRKLRKELFGKGPERIHTVFVENMAVSTLYGNL SASEQFIARTPEGREMVHAARTSLIQDLYSKQTPEGMEELMGAKLVHLFSDIKIEENI AVSVFVFDRKIDEQKEALQS*" /label="yrhF CDS" gene complement(2202885..2203253) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /label="yrhF gene" S_feature complement(2203254..2203350) /Source="Nicolas_S_feature" /locus_tag="new_2780894_2780990_c" /HighExp="T0.30H, LBGstat, T1.0H, T1.30H, G150, Lbexp, dia0, G180, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1030" promotor_-10 complement(2203336..2203355) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-10" promotor_-35 2203340..2203343 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2203356) /Source="Nicolas_upshifts" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="upshifts" promotor_-10 2203359..2203378 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2203361 /Source="Nicolas_upshifts" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="upshifts" S_feature 2203362..2203568 /Source="Nicolas_S_feature" /locus_tag="new_2781002_2781208" /HighExp="G150, Lbexp, dia0, Cold, dia5, G135, LBGstat, LBGexp, G180, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1031" promotor_-35 complement(2203371..2203375) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-35" CDS 2203569..2206511 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /EC_number="1.17.1.9" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913079, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative formate dehydrogenase" /protein_id="NP_390600.1" /db_xref="EnsemblGenomes-Gn:BSU27220" /db_xref="EnsemblGenomes-Tr:CAB14664" /db_xref="GOA:Q795Y4" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG12294" /db_xref="UniProtKB/Swiss-Prot:Q795Y4" /translation="MMDVKSISVRVDGTEIQARAGATILDILNENGIEYPQICHVPEV DPIQTCDTCIVEANGKLVRSCATVAENGMSIDLSGNRVKEAQTEAMDRLLENHLLYCT VCDNNNGNCTLHNTAEMMGIEHQKYPYTPKEDPSCAVDMSHPFYRYDPNQCIACGQCV EVCQNLQVNETLSIDWERERPRVIWDEGVPINESSCVSCGQCVTVCPCNALMEKSMLG QAGFMTGIKEDVMEPMIDLVKNVEPGYGSIFAISEVEAAMRETRTKKTKTVCTFCGVG CSFEVWTKGRDILKIQPVSDAPVNAISTCVKGKFGWDFVNSKERITKPLIRKNGAFVE SSWEEALDLVASRLGSIKEQYGKGSVGFISSSKITNEENYVIQKLARQVFETNNVDNC SRYCQSPATDGLFRTVGMGGDAGTIKDIAKAGLVIIVGANPAEGHPVLATRVKRAHKL HGQKLIVADLRKNEMAERSDLFISPKQGTDQVWLMAVTKYMIDQGWHDQAFIDENVNY FEDYKETLKTYTLDYAERITGLSKENIIQIAEMIRDADGTCVLWGMGVTQNTGGSDTS AAISNLLLATGNYRRPGAGAYPLRGHNNVQGACDMGTLPGWLPGYQHITDDKARAKFE EAYGVEIDGKPGLDNIQMLHAIEEGKMKAMYLVGEDMALVDSNANHVHDILSSLDFFV VQDIFLSRTAQYADVVLPATPSLEKDGTFTNTERRVQRLYQALPTLGDAKPDWWIIQE VANRLGANWNYSHPSDIFSEMASLSPLFAKASYEVLEGWNSFLWGSFTGESTPLLYED GFNFPDKKARFALSDWTEPAAFPEEYDLHINNGRMLEHFHEGNMTNKSKGIQAKVPNV FVEISPELAQERGVCDGSLVRLVSPFGAVKLNALITDRVRKNELYLPMNSTDKESAIN FLTGPAADKRTNTPAYKQTKVRMEVLGGCETAPLPKTNPRNKKRHPQNGVEAERKWNR PGYVHLTD*" /label="yrhE CDS" gene 2203569..2206511 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /label="yrhE gene" CDS 2206530..2207012 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10913079" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390601.1" /db_xref="EnsemblGenomes-Gn:BSU27230" /db_xref="EnsemblGenomes-Tr:CAB14665" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG12293" /db_xref="UniProtKB/Swiss-Prot:O05396" /translation="MATPITTIKKETKTAEQIKLEKIEELKELLAENEDAVSKTMTLM NELNDLGIFDAATSMLRAKEDIAKIALGQVSREPVTNLINTMMAAGGALTKADPEFTA KLLESVMAGTEQAQSFLKEDKKVGILDLLKAMNDPDINRAVGFGLQFLKGMGKELREQ *" /label="yrhD CDS" gene 2206530..2207012 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /label="yrhD gene" downshifts 2206992 /Source="Nicolas_upshifts" /id="D1393" /incds=0 /nref=65 /ntot=196 /MaxReadThrough="1.1227" /MaxDrop="6.19465" /score="27.8496451" /energy="-11.2" /TU="NA" /idTUdmin="U2096" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2207048..2207278) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17056751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390602.1" /db_xref="EnsemblGenomes-Gn:BSU27240" /db_xref="EnsemblGenomes-Tr:CAB14666" /db_xref="GOA:O05395" /db_xref="InterPro:IPR025418" /db_xref="SubtiList:BG12292" /db_xref="UniProtKB/Swiss-Prot:O05395" /translation="MNKNRMKSLKEDYKHFAFTLLAVSTFLYIGAVLPDQGLTLGQKS TMFLADCVFLAGAFFCADRSLIYKKRLEEADE*" /label="yrhC CDS" gene complement(2207048..2207278) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /label="yrhC gene" downshifts complement(2207068) /Source="Nicolas_upshifts" /id="D1394" /incds=0 /nref=60 /ntot=210 /MaxReadThrough="0.98344" /MaxDrop="5.84379" /score="15.2557797" /energy="-11.2" /TU="NA" /idTUdmin="U2097" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2207279..2207360) /Source="Nicolas_S_feature" /locus_tag="new_2784919_2785000_c" /HighExp="dia5, dia15, BT, Diami, B36, B60, nit, dia0, MG 10, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1032" CDS complement(2207361..2208500) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /EC_number="4.4.1.2" /EC_number="4.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway" /protein_id="NP_390603.1" /db_xref="EnsemblGenomes-Gn:BSU27250" /db_xref="EnsemblGenomes-Tr:CAB14667" /db_xref="GOA:O05394" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12291" /db_xref="UniProtKB/Swiss-Prot:O05394" /translation="MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEY SRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTY RVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEE LHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPG SSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPA RMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI*" /label="mccB CDS" gene complement(2207361..2208500) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /label="mccB gene" CDS complement(2208502..2209425) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /EC_number="2.5.1.47" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-synthase for the reverse transsulfuration pathway" /protein_id="NP_390604.1" /db_xref="EnsemblGenomes-Gn:BSU27260" /db_xref="EnsemblGenomes-Tr:CAB14668" /db_xref="GOA:O05393" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG12290" /db_xref="UniProtKB/Swiss-Prot:O05393" /translation="MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIK DRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREK QQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGP EMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHK TEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEE AKKASAGTNIVTVFPDSSDRYISKQIYEGGI*" /label="mccA CDS" gene complement(2208502..2209425) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /label="mccA gene" downshifts complement(2209418) /Source="Nicolas_upshifts" /id="D1395" /incds=0 /nref=16 /ntot=178 /MaxReadThrough="7.13056" /MaxDrop="3.40819" /score="0.994445584" /energy="-8.7" /TU="U2097,U2098,U2099" /idTUdmin="U2102" /TUdmin=1874 /isTUend="FALSE" /label="downshifts" S_feature complement(2209426..2209489) /Source="Nicolas_S_feature" /locus_tag="new_2787066_2787129_c" /HighExp="dia5, Diami, dia15, BT, B36, S6, LBGstat, S8, dia0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1033" CDS complement(2209490..2210185) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /EC_number="3.2.2.9" /EC_number="3.2.2.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioadenosine / S-adenosylhomocysteine nucleosidase" /protein_id="NP_390605.1" /db_xref="EnsemblGenomes-Gn:BSU27270" /db_xref="EnsemblGenomes-Tr:CAB14669" /db_xref="GOA:O32028" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010049" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG13800" /db_xref="UniProtKB/Swiss-Prot:O32028" /translation="MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVI LLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDV TAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVE EVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVH STELVLKVIKRIH*" /label="mtnN CDS" gene complement(2209490..2210185) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /label="mtnN gene" promotor_-10 complement(2209925..2209944) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2209943) /Source="Nicolas_upshifts" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2209957..2209966) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2210206..2210847) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 17056751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_390606.1" /db_xref="EnsemblGenomes-Gn:BSU27280" /db_xref="EnsemblGenomes-Tr:CAB14670" /db_xref="GOA:O32029" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023553" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13799" /db_xref="UniProtKB/Swiss-Prot:O32029" /translation="MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRK SGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFP EPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAID KARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR*" /label="yrrT CDS" gene complement(2210206..2210847) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /label="yrrT gene" promotor_-10 complement(2210414..2210433) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2210433) /Source="Nicolas_upshifts" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2210450..2210453) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2210899..2210908 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2210905..2210924) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2210911) /Source="Nicolas_upshifts" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2210921..2210940 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2210930..2210994 /Source="Nicolas_S_feature" /locus_tag="new_2788570_2788634" /HighExp="BT, S6, S7, S8, S5, B36, G/S, Pyr, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1034" upshifts 2210930 /Source="Nicolas_upshifts" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2210940..2210943) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2210975..2210982 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2210996 /Source="Nicolas_upshifts" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2210998..2211015 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2211040..2211243 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390607.1" /db_xref="EnsemblGenomes-Gn:BSU27290" /db_xref="EnsemblGenomes-Tr:CAB14671" /db_xref="InterPro:IPR019686" /db_xref="SubtiList:BG13811" /db_xref="UniProtKB/Swiss-Prot:O32030" /translation="MNFQLDLIKDKVEFFEAASLQELEKKINTQIENNKAIMLRVKSV SHQTLVAEGRILYSAVVHFSAEA*" /label="yrzA CDS" gene 2211040..2211243 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /label="yrzA gene" downshifts 2211250 /Source="Nicolas_upshifts" /id="D1396" /incds=0 /nref=205 /ntot=257 /MaxReadThrough="1.11529" /MaxDrop="5.39095" /score="26.0850303" /energy="-14.2" /TU="NA" /idTUdmin="U2101" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2211280..2211981) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679248" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390608.1" /db_xref="EnsemblGenomes-Gn:BSU27300" /db_xref="EnsemblGenomes-Tr:CAB14672" /db_xref="GOA:O32031" /db_xref="InterPro:IPR009988" /db_xref="SubtiList:BG13798" /db_xref="UniProtKB/Swiss-Prot:O32031" /translation="MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSP SSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDS SSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATY DSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITW VDEKGWKPTKVEKLK*" /label="yrrS CDS" gene complement(2211280..2211981) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /label="yrrS gene" downshifts complement(2211292) /Source="Nicolas_upshifts" /id="D1397" /incds=0 /nref=237 /ntot=265 /MaxReadThrough="1.64695" /MaxDrop="6.48551" /score="22.1367505" /energy="-14.2" /TU="NA" /idTUdmin="U2102" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2212046..2213800) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14679248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein PBP4B" /protein_id="NP_390609.1" /db_xref="EnsemblGenomes-Gn:BSU27310" /db_xref="EnsemblGenomes-Tr:CAB14673" /db_xref="GOA:O32032" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13797" /db_xref="UniProtKB/Swiss-Prot:O32032" /translation="MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLI QESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGM SEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASH TIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGN PLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVL GIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYG EPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLY HETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGE KRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQ DLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTN SVFYDIVKKVHEIEINQK*" /label="pbpI CDS" gene complement(2212046..2213800) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /label="pbpI gene" misc_feature complement(2212074..2212093) /Source="Nicolas_upshift_promotors" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2212084) /Source="Nicolas_upshifts" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2213115..2213130) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2213118) /Source="Nicolas_upshifts" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2213143..2213152) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2213346..2213364) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2213360) /Source="Nicolas_upshifts" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2213379..2213386 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2213379..2213384) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2213401..2213420 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2213406 /Source="Nicolas_upshifts" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2213854..2214327) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10910724, 16014871, 16707701, 21515770, 28976965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10910724, 16014871, 16707701, 21515770, 28976965; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription elongation factor resolving backtracking / stalling" /protein_id="NP_390610.1" /db_xref="EnsemblGenomes-Gn:BSU27320" /db_xref="EnsemblGenomes-Tr:CAB14674" /db_xref="GOA:P80240" /db_xref="InterPro:IPR001437" /db_xref="InterPro:IPR006359" /db_xref="InterPro:IPR018151" /db_xref="InterPro:IPR022691" /db_xref="InterPro:IPR023459" /db_xref="InterPro:IPR028624" /db_xref="InterPro:IPR036805" /db_xref="InterPro:IPR036953" /db_xref="SubtiList:BG19019" /db_xref="UniProtKB/Swiss-Prot:P80240" /translation="MAQEKVFPMTAEGKQKLEQELEYLKTVKRKEVVERIKIARSFGD LSENSEYDSAKEEQAFVEGRVTTLENMIRNAKIIEDDGGSNVVGLGKTVTFVELPDGD EESYTIVGSAEADPFEGKISNDSPIAKSLLGKKVDEEVTVQTPGGEMLVKIVKIS*" /label="greA CDS" gene complement(2213854..2214327) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /label="greA gene" downshifts complement(2213861) /Source="Nicolas_upshifts" /id="D1398" /incds=0 /nref=130 /ntot=229 /MaxReadThrough="5.30316" /MaxDrop="4.90519" /score="34.2316821" /energy="-17" /TU="U2107" /idTUdmin="U2106" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(2214328..2214460) /Source="Nicolas_S_feature" /locus_tag="new_2791968_2792100_c" /HighExp="HPh, C90, dia5, dia15, Diami, H2O2, dia0, Etha, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1035" promotor_-10 complement(2214442..2214461) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2214460) /Source="Nicolas_upshifts" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2214462..2214570) /Source="Nicolas_S_feature" /locus_tag="new_2792102_2792210_c" /HighExp="HPh, G180, G135, LBGexp, dia0, Paraq, Oxctl, G150, LPh, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1036" promotor_-35 complement(2214475..2214482) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2214563..2214582) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2214570) /Source="Nicolas_upshifts" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2214578..2215213) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /EC_number="2.7.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 6208029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridine kinase" /protein_id="NP_390611.1" /db_xref="EnsemblGenomes-Gn:BSU27330" /db_xref="EnsemblGenomes-Tr:CAB14675" /db_xref="GOA:O32033" /db_xref="InterPro:IPR000764" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR026008" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12696" /db_xref="UniProtKB/Swiss-Prot:O32033" /translation="MGKNPVVIGIAGGSGSGKTSVTRSIYEQFKGHSILMIQQDLYYK DQSHLPFEERLNTNYDHPLAFDNDYLIEHIQDLLNYRPIEKPIYDYKLHTRSEETVHV EPKDVIILEGILVLEDKRLRDLMDIKLYVDTDADLRIIRRIMRDINERGRSIDSVIEQ YVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL*" /label="udk CDS" gene complement(2214578..2215213) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /label="udk gene" promotor_-35 complement(2214598..2214602) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2214708..2214713 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2214729..2214747 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2214736 /Source="Nicolas_upshifts" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2215220..2216488) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase large subunit" /protein_id="NP_390612.1" /db_xref="EnsemblGenomes-Gn:BSU27340" /db_xref="EnsemblGenomes-Tr:CAB14676" /db_xref="GOA:O32034" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032525" /db_xref="SubtiList:BG13796" /db_xref="UniProtKB/Swiss-Prot:O32034" /translation="MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADA VFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKA LGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLAR ETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDY DLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVA TVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHA KKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGN ELDAARHPLQIVKFKLDKKIYPSNMMRKGK*" /label="yrrO CDS" gene complement(2215220..2216488) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /label="yrrO gene" CDS complement(2216507..2217436) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase small subunit" /protein_id="NP_390613.1" /db_xref="EnsemblGenomes-Gn:BSU27350" /db_xref="EnsemblGenomes-Tr:CAB14677" /db_xref="GOA:O32035" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG13795" /db_xref="UniProtKB/Swiss-Prot:O32035" /translation="MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSR EDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMA ARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIE IQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENG THIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDE YEAKKEDWIERIESIQPVNRKIDTGFFFKETVY*" /label="yrrN CDS" gene complement(2216507..2217436) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /label="yrrN gene" CDS complement(2217442..2218095) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /EC_number="2.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA O-methyltransferase" /protein_id="NP_390614.1" /db_xref="EnsemblGenomes-Gn:BSU27360" /db_xref="EnsemblGenomes-Tr:CAB14678" /db_xref="GOA:O32036" /db_xref="InterPro:IPR002935" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13794" /db_xref="UniProtKB/Swiss-Prot:O32036" /translation="MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGME VLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQ LDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDN VLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR* " /label="yrrM CDS" gene complement(2217442..2218095) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /label="yrrM gene" S_feature complement(2218096..2218200) /Source="Nicolas_S_feature" /locus_tag="new_2795736_2795840_c" /HighExp="LBGexp, G180, H2O2, G150, Paraq, Oxctl, G135, dia15, C30, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1037" promotor_-10 complement(2218182..2218201) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2218200) /Source="Nicolas_upshifts" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2218217..2218221) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2218247..2219329) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved membrane associated protein" /protein_id="NP_390615.1" /db_xref="EnsemblGenomes-Gn:BSU27370" /db_xref="EnsemblGenomes-Tr:CAB14679" /db_xref="GOA:O34758" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13793" /db_xref="UniProtKB/Swiss-Prot:O34758" /translation="MYINQQKKSFFNKKRIILSSIVVLFLIIGGAFLYGKSLLEPVEK DSKTTVNINIPSGSSVSAIASILKKNDVIKSEKAFQYYVKYKGASGFQAGFYHLNKGM DLDAIIQKLTSGATGYAFQITVTEGAQLTQIAAAIADETKYSKKQVIAKLDDETFINQ LKKEFPDTVTNDVFNKNIKHPLEGYLFPATYPFNDPDTSLEDIIKAMIKQTNSYVETY KSEMKKNKVSVHKLLTMASLIEEEATEKADRHKIASVFYNRLKKKMPLQTDPTVLYAA GKHKDRVLYKDLEIDSPYNTYKNTGLTPGPIANAGMSSWEAALHPDKTDYLYFLAKSN GEVVFTKTLKEHNKAKEKYISSKNEK*" /label="yrrL CDS" gene complement(2218247..2219329) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /label="yrrL gene" downshifts complement(2218281) /Source="Nicolas_upshifts" /id="D1399" /incds=0 /nref=21 /ntot=144 /MaxReadThrough="3.5258" /MaxDrop="3.97301" /score="10.5327118" /energy="-11" /TU="U2110" /idTUdmin="U2111" /TUdmin=1173 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2219345..2219364) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2219365) /Source="Nicolas_upshifts" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2219379..2219382) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2219455) /Source="Nicolas_upshifts" /id="D1400" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="2.55298" /MaxDrop="6.9121" /score="36.0941054" /energy="-15" /TU="NA" /idTUdmin="U2111" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2219460..2219741) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_390616.1" /db_xref="EnsemblGenomes-Gn:BSU27380" /db_xref="EnsemblGenomes-Tr:CAB14680" /db_xref="InterPro:IPR009711" /db_xref="SubtiList:BG13812" /db_xref="UniProtKB/Swiss-Prot:O34828" /translation="MEHGEKNITIVDDQGNEQLCEVLFTFENEEFGKSYVLYYPIESK DDEEVEILASSFTPNEDGENGELFPIETDEEWDMIEETLNTFLADEDEE*" /label="yrzB CDS" gene complement(2219460..2219741) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /label="yrzB gene" downshifts complement(2219520) /Source="Nicolas_upshifts" /id="D1401" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.68915" /MaxDrop="5.19246" /score="36.0941054" /energy="-15" /TU="U2111,U2113,U2114,U2115" /idTUdmin="U2111" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2219759..2220175) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 14512736, 16021622, 22720735, 23251031, 25545592; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pre-16S ribosomal RNA maturation enzyme" /protein_id="NP_390617.1" /db_xref="EnsemblGenomes-Gn:BSU27390" /db_xref="EnsemblGenomes-Tr:CAB14681" /db_xref="GOA:O34634" /db_xref="InterPro:IPR005227" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR037027" /db_xref="PDB:1VHX" /db_xref="SubtiList:BG13792" /db_xref="UniProtKB/Swiss-Prot:O34634" /translation="MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSR LSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMA AEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN*" /label="rimF CDS" gene complement(2219759..2220175) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /label="rimF gene" promotor_-10 complement(2220007..2220025) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2220026) /Source="Nicolas_upshifts" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2220041..2220046) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2220183..2220449) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_054589.1" /db_xref="EnsemblGenomes-Gn:BSU27400" /db_xref="EnsemblGenomes-Tr:CAE01464" /db_xref="InterPro:IPR009309" /db_xref="SubtiList:BG14184" /db_xref="UniProtKB/Swiss-Prot:Q7WY61" /translation="MSSFDKTMKFNFSDDSAETNVNEVLITVYDALQEKGYNPINQIV GYLLSGDPAYIPRHRDARNLIRKLERDELIEELVKSYLEQHKEA*" /label="yrzL CDS" gene complement(2220183..2220449) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /label="yrzL gene" promotor_-35 2220337..2220345 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2220360..2220379 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2220368..2221557 /Source="Nicolas_S_feature" /locus_tag="new_2798008_2799197" /HighExp="S6, C30, C90, S8, S7, Gly, G135, Fru, G180, M/G" /AntisenseName="alaS" /AntisenseCor="-0.27843994691040502" /AntisenseRegPval="-5.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1038" upshifts 2220368 /Source="Nicolas_upshifts" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2220450..2220510) /Source="Nicolas_S_feature" /locus_tag="new_2798090_2798150_c" /HighExp="LBGtran, LBGexp, G135, C90, G150, G180, LBGstat, Oxctl, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.994, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1039" promotor_-10 complement(2220504..2220523) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2220510) /Source="Nicolas_upshifts" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2220534..2223170) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /EC_number="6.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12554667, 12682299, 17329819, 22720735, 25918376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanyl-tRNA synthetase" /protein_id="NP_390618.1" /db_xref="EnsemblGenomes-Gn:BSU27410" /db_xref="EnsemblGenomes-Tr:CAB14682" /db_xref="GOA:O34526" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="SubtiList:BG12563" /db_xref="UniProtKB/Swiss-Prot:O34526" /translation="MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSG VATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKE EAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWD IGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYT PLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFK VIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAE IMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADV FKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGAL RDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIG DKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNH TATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWA SIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLF KIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAE LKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAK LGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAG GKQPEKLEEALASVEDWVKSVL*" /label="alaS CDS" gene complement(2220534..2223170) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /label="alaS gene" promotor_-35 complement(2220537..2220544) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2222936..2222954) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2222952) /Source="Nicolas_upshifts" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2222968..2222975) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2223171..2223249) /Source="Nicolas_S_feature" /locus_tag="new_2800811_2800889_c" /HighExp="G150, LBGexp, G135, G180, Oxctl, LBGtran, Lbexp, Paraq, dia15, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1040" misc_RNA complement(2223250..2223457) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /product="T-box riboswitch specific of alanine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboA RNA" gene complement(2223250..2223457) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /label="tboA gene" promotor_-10 complement(2223465..2223484) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2223480) /Source="Nicolas_upshifts" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2223499..2223506) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2223501..2224562) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_390619.1" /db_xref="EnsemblGenomes-Gn:BSU27420" /db_xref="EnsemblGenomes-Tr:CAB14683" /db_xref="GOA:O34472" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13791" /db_xref="UniProtKB/Swiss-Prot:O34472" /translation="MLQKPVQLLLWVAICLLVLLTVYVFFMLDMLWSPFWLVIKTIFI PLIISIFISYLLLPVTEWLHGKGLPRTLSILVIYVLFFGGIGWALYKGVPVLIVQLTD LSENIPMFAETYNGLLLHVHNHTDDWPDGMHHRIDKMIRQTEAFFAGTIEGAISGIRN VLDYFLIAATIPFLVFYMVKDIELMKKTVWYLTPKSWRKRGSAFLRDVDDSLGDYIRG QLLVCLILGVIAGISFWVFGLPYPLILGLISGVTNVIPYFGPFIGAVPALLIAMTISV KAVLVVVITVFILQFMEGNILSPFIVGRSLKMHPVVIMLALLAGGELAGIVGMILAVP ATAVLKVMMIHFLRMRTEH*" /label="yrrI CDS" gene complement(2223501..2224562) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /label="yrrI gene" promotor_-35 2224471..2224476 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2224482..2224717 /Source="Nicolas_S_feature" /locus_tag="new_2802122_2802357" /HighExp="S5, S6, S4, S8, S3, S7, LoTm, BT, M9-stat, T5.0H" /AntisenseName="yrrI" /AntisenseCor="0.71790030040923003" /AntisenseRegPval="-43.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1041" upshifts 2224483 /Source="Nicolas_upshifts" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2224492..2224510 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2224579..2224590) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2224580) /Source="Nicolas_upshifts" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2224604..2224610) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2224718..2225446 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (ATP-binding protein)" /protein_id="NP_390620.1" /db_xref="EnsemblGenomes-Gn:BSU27430" /db_xref="EnsemblGenomes-Tr:CAB14684" /db_xref="GOA:O34677" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11485" /db_xref="UniProtKB/Swiss-Prot:O34677" /translation="MITFQNVNKHYGDFHVLKQINLQIEKGEVVVIIGPSGSGKSTLL RCINRLESINEGVLTVNGTAINDRKTDINQVRQNIGMVFQHFHLYPHKTVLQNIMLAP VKVLRQSPEQAKETARYYLEKVGIPDKADAYPSQLSGGQQQRVAIARGLAMKPEVMLF DEPTSALDPEMIGEVLDVMKTLAKEGMTMVVVTHEMGFAKEVADRIVFIDEGKILEEA VPAEFYANPKEERARLFLSRILNH*" /label="glnQ CDS" gene 2224718..2225446 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /label="glnQ gene" downshifts complement(2225174) /Source="Nicolas_upshifts" /id="D1402" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="1.29649" /MaxDrop="3.29152" /score="-3.35464926" /energy="-5.4" /TU="NA" /idTUdmin="U2117" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" CDS 2225468..2226289 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (glutamine-binding lipoprotein)" /protein_id="NP_390621.1" /db_xref="EnsemblGenomes-Gn:BSU27440" /db_xref="EnsemblGenomes-Tr:CAB14685" /db_xref="GOA:O34563" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11486" /db_xref="UniProtKB/Swiss-Prot:O34563" /translation="MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKD NDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRI PMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKV LAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKN YQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE*" /label="glnH CDS" gene 2225468..2226289 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /label="glnH gene" CDS 2226350..2227000 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390622.1" /db_xref="EnsemblGenomes-Gn:BSU27450" /db_xref="EnsemblGenomes-Tr:CAB14686" /db_xref="GOA:O34671" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11487" /db_xref="UniProtKB/Swiss-Prot:O34671" /translation="MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRIT VFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIA EAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSI LGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY*" /label="glnM CDS" gene 2226350..2227000 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /label="glnM gene" CDS 2227017..2227673 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390623.1" /db_xref="EnsemblGenomes-Gn:BSU27460" /db_xref="EnsemblGenomes-Tr:CAB14687" /db_xref="GOA:O34606" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11488" /db_xref="UniProtKB/Swiss-Prot:O34606" /translation="MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLR YAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAM LSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDT SLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT *" /label="glnP CDS" gene 2227017..2227673 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /label="glnP gene" downshifts 2227672 /Source="Nicolas_upshifts" /id="D1403" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.21558" /MaxDrop="6.08472" /score="5.38937989" /energy="-11.7" /TU="NA" /idTUdmin="U2116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2227708..2227839) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097766.1" /db_xref="EnsemblGenomes-Gn:BSU27468" /db_xref="EnsemblGenomes-Tr:CAX52672" /db_xref="InterPro:IPR025029" /db_xref="UniProtKB/Swiss-Prot:C0H461" /translation="MNRTMTSLLAMGAGALVYRMATQSDMLNNRSMKRMRRRITKMF* " /label="yrzQ CDS" gene complement(2227708..2227839) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /label="yrzQ gene" downshifts complement(2227726) /Source="Nicolas_upshifts" /id="D1404" /incds=0 /nref=50 /ntot=77 /MaxReadThrough="1.58565" /MaxDrop="8.21989" /score="5.69801689" /energy="-11.7" /TU="NA" /idTUdmin="U2118" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2227861..2228052) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097767.1" /db_xref="EnsemblGenomes-Gn:BSU27469" /db_xref="EnsemblGenomes-Tr:CAX52673" /db_xref="UniProtKB/Swiss-Prot:C0H462" /translation="MLICPNCKSKDIGKIGVNQYYCWGCFIELTVAKGKIATHQVEED GTLSSLDDLFSEDERSINF*" /label="yrzR CDS" gene complement(2227861..2228052) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /label="yrzR gene" CDS complement(2228064..2228588) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390624.1" /db_xref="EnsemblGenomes-Gn:BSU27470" /db_xref="EnsemblGenomes-Tr:CAB14688" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13790" /db_xref="UniProtKB/Swiss-Prot:O34402" /translation="MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTI SDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSC FTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRAD SLVEVRKDEIVLNG*" /label="yrrD CDS" gene complement(2228064..2228588) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /label="yrrD gene" upshifts complement(2228175) /Source="Nicolas_upshifts" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2228179..2228190) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2228205..2228211) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2228559..2228570) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2228565) /Source="Nicolas_upshifts" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2228585..2228591) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2228646..2231042) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /EC_number="3.1.11.5" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3537961, 11557815, 21170359, 22720735, 24443534, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3537961, 11557815, 21170359, 22720735, 24443534, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5'-3' helicase associated to SSB; exonuclease V" /protein_id="NP_390625.1" /db_xref="EnsemblGenomes-Gn:BSU27480" /db_xref="EnsemblGenomes-Tr:CAB14689" /db_xref="GOA:O34481" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="InterPro:IPR029493" /db_xref="SubtiList:BG13789" /db_xref="UniProtKB/Swiss-Prot:O34481" /translation="MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSE AIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYL SSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQG LEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSR MGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMD AANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLA LGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSL DPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIE GKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIP TVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVA NALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDK ILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHA YCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVK NNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ *" /label="recDB CDS" gene complement(2228646..2231042) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /label="recDB gene" downshifts complement(2228672) /Source="Nicolas_upshifts" /id="D1405" /incds=0 /nref=32 /ntot=211 /MaxReadThrough="2.07603" /MaxDrop="3.57113" /score="41.0323102" /energy="-10.8" /TU="NA" /idTUdmin="U2121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2228892..2228898 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2228906 /Source="Nicolas_upshifts" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2228913..2228924 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2228926..2229275 /Source="Nicolas_S_feature" /locus_tag="new_2806566_2806915" /HighExp="S8, S5, S6, S7, S4, C30, nit, ferm, G135, T5.0H" /AntisenseName="yrrC" /AntisenseCor="-0.46935785055870999" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1042" downshifts complement(2229027) /Source="Nicolas_upshifts" /id="D1406" /incds=1 /nref=16 /ntot=163 /MaxReadThrough="4.93428" /MaxDrop="2.86437" /score="41.0323102" /energy="-10.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-355" /isTUend="FALSE" /label="downshifts" CDS complement(2231067..2231687) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11777911, 12594026, 18180259; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative tetratricopeptide repeat family protein" /protein_id="NP_390626.1" /db_xref="EnsemblGenomes-Gn:BSU27490" /db_xref="EnsemblGenomes-Tr:CAB14690" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /db_xref="InterPro:IPR019734" /db_xref="PDB:2Q7F" /db_xref="SubtiList:BG13788" /db_xref="UniProtKB/Swiss-Prot:O34452" /translation="MQEGDYEKAAEAFTKAIEENKEDAIPYINFANLLSSVNELERAL AFYDKALELDSSAATAYYGAGNVYVVKEMYKEAKDMFEKALRAGMENGDLFYMLGTVL VKLEQPKLALPYLQRAVELNENDTEARFQFGMCLANEGMLDEALSQFAAVTEQDPGHA DAFYNAGVTYAYKENREKALEMLDKAIDIQPDHMLALHAKKLIDPS*" /label="yrrB CDS" gene complement(2231067..2231687) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /label="yrrB gene" CDS complement(2231773..2232888) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /EC_number="2.8.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-specific 2-thiouridylase" /protein_id="NP_390627.3" /db_xref="EnsemblGenomes-Gn:BSU27500" /db_xref="EnsemblGenomes-Tr:CAB14691" /db_xref="GOA:O35020" /db_xref="InterPro:IPR004506" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023382" /db_xref="SubtiList:BG13787" /db_xref="UniProtKB/Swiss-Prot:O35020" /translation="MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDD TDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDV LCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDENKDQTYFLNQLT EDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQ PGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHN PLLYSDKITATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQ VRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV*" /label="mnmA CDS" gene complement(2231773..2232888) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /label="mnmA gene" downshifts complement(2231774) /Source="Nicolas_upshifts" /id="D1407" /incds=0 /nref=2 /ntot=69 /MaxReadThrough="6.45399" /MaxDrop="4.31641" /score="2.49091848" /energy="-7.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" CDS complement(2232919..2234058) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496536, 10930739, 12682299, 17064282, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496536, 10930739, 12682299, 17064282, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase involved in U34 tRNA thiolation" /protein_id="NP_390629.2" /db_xref="EnsemblGenomes-Gn:BSU27510" /db_xref="EnsemblGenomes-Tr:CAB14693" /db_xref="GOA:O34599" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG13809" /db_xref="UniProtKB/Swiss-Prot:O34599" /translation="MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESR KWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHA VLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIE EIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDV KLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLR DAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSH VLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT*" /label="iscSA CDS" gene complement(2232919..2234058) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /label="iscSA gene" promotor_-10 complement(2233625..2233644) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2233637) /Source="Nicolas_upshifts" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2233658..2233665) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2234077..2234493) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of cysteine biosynthesis" /protein_id="NP_390630.2" /db_xref="EnsemblGenomes-Gn:BSU27520" /db_xref="EnsemblGenomes-Tr:CAB14694" /db_xref="GOA:O34527" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2Y75" /db_xref="SubtiList:BG13813" /db_xref="UniProtKB/Swiss-Prot:O34527" /translation="MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQ LVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRE LWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI*" /label="cymR CDS" gene complement(2234077..2234493) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /label="cymR gene" S_feature complement(2234494..2234591) /Source="Nicolas_S_feature" /locus_tag="new_2812134_2812231_c" /HighExp="Cold, T3.0H, G135, LBGexp, G180, G150, Salt, Lbexp, H2O2, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1043" promotor_-10 complement(2234576..2234595) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2234591) /Source="Nicolas_upshifts" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2234611..2234614) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2234639..2234646 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2234660..2234679 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2234668 /Source="Nicolas_upshifts" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="upshifts" CDS 2234696..2235961 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15743409, 17641684, 21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743409, 17641684, 21170359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-dependent ATPase active at replication forks" /protein_id="NP_390631.1" /db_xref="EnsemblGenomes-Gn:BSU27530" /db_xref="EnsemblGenomes-Tr:CAB14695" /db_xref="GOA:O34528" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR021886" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032423" /db_xref="SubtiList:BG13808" /db_xref="UniProtKB/Swiss-Prot:O34528" /translation="MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILY GPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRL DKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALER ALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITL ETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIAR RLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAIL AIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPL KNKQYYKPKQTGKFESALKQVYDKLMKRK*" /label="rarA CDS" gene 2234696..2235961 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /label="rarA gene" downshifts 2235960 /Source="Nicolas_upshifts" /id="D1408" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="1.09429" /MaxDrop="4.5261" /score="14.6665846" /energy="-12" /TU="NA" /idTUdmin="U2123" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2236003..2236767) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /EC_number="6.1.-.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12177353, 20097860, 23242255, 27913733, 28671653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase)" /protein_id="NP_390632.3" /db_xref="EnsemblGenomes-Gn:BSU27540" /db_xref="EnsemblGenomes-Tr:CAB14713" /db_xref="GOA:O32037" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13807" /db_xref="UniProtKB/Swiss-Prot:O32037" /translation="MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARS GVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYT EETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIAD ISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKM PPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK*" /label="tcdA CDS" gene complement(2236003..2236767) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /label="tcdA gene" downshifts complement(2236021) /Source="Nicolas_upshifts" /id="D1409" /incds=0 /nref=246 /ntot=264 /MaxReadThrough="2.35294" /MaxDrop="7.20309" /score="44.7253801" /energy="-12" /TU="NA" /idTUdmin="U2125" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2236851..2237051) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /product="6Sb RNA" /experiment="publication(s) with functional evidences, PMID:12177353, 15793584, 15811922, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 15793584, 15811922, 25576829, 26873600; Product type n: RNA" /label="ssrSB RNA" gene complement(2236851..2237051) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /label="ssrSB gene" downshifts complement(2236869) /Source="Nicolas_upshifts" /id="D1410" /incds=0 /nref=81 /ntot=303 /MaxReadThrough="7.44881" /MaxDrop="6.73892" /score="44.7253801" /energy="-12" /TU="U2125,U2127" /idTUdmin="U2125" /TUdmin="-848" /isTUend="FALSE" /label="downshifts" upshifts 2237038 /Source="Nicolas_upshifts" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2237039..2237048 /Source="Nicolas_upshift_promotors" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2237049..2237068) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2237060) /Source="Nicolas_upshifts" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2237081..2237088) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2237103..2238881) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /EC_number="6.1.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12177353, 26804570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartyl-tRNA synthetase, promiscuous (also recognizes tRNAasn)" /protein_id="NP_390633.1" /db_xref="EnsemblGenomes-Gn:BSU27550" /db_xref="EnsemblGenomes-Tr:CAB14714" /db_xref="GOA:O32038" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004115" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004524" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029351" /db_xref="SubtiList:BG12572" /db_xref="UniProtKB/Swiss-Prot:O32038" /translation="MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRT GIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGV NVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDE NGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQI ARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPR MTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAG DYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGD LLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAA HHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGF SPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCL MTEAPGEVSDAQLDELHLSIKKKVKN*" /label="aspS CDS" gene complement(2237103..2238881) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /label="aspS gene" CDS complement(2238895..2240169) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /EC_number="6.1.1.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28321488; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase" /protein_id="NP_390634.1" /db_xref="EnsemblGenomes-Gn:BSU27560" /db_xref="EnsemblGenomes-Tr:CAB14715" /db_xref="GOA:O32039" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR015807" /db_xref="InterPro:IPR033656" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG12605" /db_xref="UniProtKB/Swiss-Prot:O32039" /translation="MGYNIPRGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIF EHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQP TKLYYVGPMFRYERPQTGRYRQFYQFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENV KLVINSLGDQDSRKSYREALVKHFEPRIEEFCSDCQSRLHTNPLRILDCKKDRDHELM KSAPSILTYLNEESAAYFEKVKQYLNDLGISYEIDPNLVRGLDYYNHTAFEIMSNAEG FGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGIDCYI VTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDELA QNKINVKDAQTGEQIEVALDEFIHVMKANQKG*" /label="hisS CDS" gene complement(2238895..2240169) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /label="hisS gene" misc_RNA complement(2240259..2240491) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /product="T-box riboswitch controlling synthesis of histidine and aspartate tRNA ligases" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.3: Control" /label="tboH RNA" gene complement(2240259..2240491) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /label="tboH gene" downshifts complement(2240289) /Source="Nicolas_upshifts" /id="D1411" /incds=0 /nref=71 /ntot=180 /MaxReadThrough="7.0761" /MaxDrop="5.61082" /score="40.6097692" /energy="-23.7" /TU="U2127" /idTUdmin="U2128" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2240501..2240504 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2240515..2240534) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2240519..2240538 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2240521..2240805 /Source="Nicolas_S_feature" /locus_tag="new_2818161_2818445" /HighExp="H2O2, G135, G180, C30, G150, Paraq, Oxctl, dia15, LBGstat, LBGexp" /AntisenseName="yrzK" /AntisenseCor="-0.27832941694878799" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1044" upshifts 2240521 /Source="Nicolas_upshifts" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2240534) /Source="Nicolas_upshifts" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2240549..2240556) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2240551..2240721) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390635.1" /db_xref="EnsemblGenomes-Gn:BSU27570" /db_xref="EnsemblGenomes-Tr:CAB14716" /db_xref="InterPro:IPR035378" /db_xref="SubtiList:BG13820" /db_xref="UniProtKB/Swiss-Prot:O32040" /translation="MKYHPKMGRAFHDGEANLHYSDHADPDTTGYLTETASEFGLMSK EAALRKNNRNKA*" /label="yrzK CDS" gene complement(2240551..2240721) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /label="yrzK gene" promotor_-10 complement(2240752..2240763) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-10" upshifts complement(2240769) /Source="Nicolas_upshifts" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="upshifts" promotor_-35 complement(2240778..2240784) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-35" promotor_-35 2240781..2240788 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2240802..2240820 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2240807 /Source="Nicolas_upshifts" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2240854..2242410 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /EC_number="3.5.1.28" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetylmuramoyl-L-alanine amidase, family 3" /protein_id="NP_390636.1" /db_xref="EnsemblGenomes-Gn:BSU27580" /db_xref="EnsemblGenomes-Tr:CAB14717" /db_xref="GOA:O32041" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR017293" /db_xref="SubtiList:BG13806" /db_xref="UniProtKB/Swiss-Prot:O32041" /translation="MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSG PGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSS DTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYV TSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNE KNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDAST SASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTSKSAEEAGEPPVSDS PSGNGSLNNKTIIVDPGHGGKDSGTIGYSGKFEKNLTIKTAKLLASKLRSAGADVYVT RQDDTFVSLQSRVSTSHYRNADAFISIHYDSYADTSTRGSTAYYYSPAKDQELASDVH SEVVKRSSIPDRGVLFGDYYVLRENRQPAMLYELGYVSHPQEEAIVHSNSYQEKVTDG IESGLEKYFQ*" /label="yrvJ CDS" gene 2240854..2242410 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /label="yrvJ gene" downshifts 2242389 /Source="Nicolas_upshifts" /id="D1412" /incds=0 /nref=199 /ntot=249 /MaxReadThrough="2.10072" /MaxDrop="7.40599" /score="44.9570925" /energy="-9.9" /TU="U2126" /idTUdmin="U2129" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2242437..2242835) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15292242, 15525705, 16844682, 18700836, 28362257; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gly-tRNA(Ala) deacylase / D-Tyr-tRNATyr deacylase" /protein_id="NP_390637.2" /db_xref="EnsemblGenomes-Gn:BSU27590" /db_xref="EnsemblGenomes-Tr:CAB14718" /db_xref="GOA:O32042" /db_xref="InterPro:IPR003732" /db_xref="InterPro:IPR023509" /db_xref="SubtiList:BG13805" /db_xref="UniProtKB/Swiss-Prot:O32042" /translation="MDEEVVGQIGQGLMVLVGITHDDTEDDAAYLADKVVNLRIFDDS EGKMNLSLVDIGGEILSVSQFTLYGDTKKGRRPNYMNAAKPDKALGLYEKWNDLLREK GIKVETGTFGAMMDVQLTNSGPVTLIMDSK*" /label="dtd CDS" gene complement(2242437..2242835) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /label="dtd gene" downshifts complement(2242445) /Source="Nicolas_upshifts" /id="D1413" /incds=0 /nref=152 /ntot=267 /MaxReadThrough="2.01735" /MaxDrop="9.47739" /score="37.3693259" /energy="-9.9" /TU="NA" /idTUdmin="U2130" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2242889..2245093) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /EC_number="2.7.6.5" /EC_number="3.1.7.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTP pyrophosphokinase (RelA/SpoT)" /protein_id="NP_390638.2" /db_xref="EnsemblGenomes-Gn:BSU27600" /db_xref="EnsemblGenomes-Tr:CAB14719" /db_xref="GOA:O54408" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004811" /db_xref="InterPro:IPR007685" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR033655" /db_xref="SubtiList:BG12665" /db_xref="UniProtKB/Swiss-Prot:O54408" /translation="MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYR KSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLV DGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYV DEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIK DCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHE IAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSD MVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVE ILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFEL KDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKI VQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVH REDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNET KTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN*" /label="rsh CDS" gene complement(2242889..2245093) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /label="rsh gene" promotor_-10 complement(2245122..2245141) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2245129) /Source="Nicolas_upshifts" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2245131..2245221) /Source="Nicolas_S_feature" /locus_tag="new_2822771_2822861_c" /HighExp="Cold, G135, G180, G150, H2O2, Paraq, Oxctl, C30, LBGexp, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="0.951, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 1" /label="S1045" promotor_-35 complement(2245156..2245163) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2245185 /Source="Nicolas_upshifts" /id="D1414" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.75679" /MaxDrop="3.54336" /score="0.486890657" /energy="-12.7" /TU="NA" /idTUdmin="U2126" /TUdmin=2772 /isTUend="FALSE" /label="downshifts" CDS complement(2245261..2245773) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /EC_number="2.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 9383190, 15629952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 9383190, 15629952; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine phosphoribosyltransferase" /protein_id="NP_390639.1" /db_xref="EnsemblGenomes-Gn:BSU27610" /db_xref="EnsemblGenomes-Tr:CAB14720" /db_xref="GOA:O34443" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005764" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG12568" /db_xref="UniProtKB/Swiss-Prot:O34443" /translation="MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYA KEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLT IHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE DYDILTLMKY*" /label="apt CDS" gene complement(2245261..2245773) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /label="apt gene" downshifts complement(2245266) /Source="Nicolas_upshifts" /id="D1415" /incds=0 /nref=39 /ntot=228 /MaxReadThrough="5.36411" /MaxDrop="4.05036" /score="2.83935873" /energy="-6.8" /TU="U2131,U2132,U2133" /idTUdmin="U2131" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" CDS complement(2245779..2248139) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21087930, 21170359, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21087930, 21170359, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="single-strand DNA-specific exonuclease" /protein_id="NP_390640.1" /db_xref="EnsemblGenomes-Gn:BSU27620" /db_xref="EnsemblGenomes-Tr:CAB14721" /db_xref="GOA:O32044" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR004610" /db_xref="InterPro:IPR018779" /db_xref="SubtiList:BG13804" /db_xref="UniProtKB/Swiss-Prot:O32044" /translation="MLASKMRWEIQRPDQDKVKSLTEQLHITPLVASLLVKRGFDTAE SARLFLHTKDADFYDPFEMKGMKEAADRIKQAISQQEKIMIYGDYDADGVTSTSVMLH TLQKLSAQVDFYIPDRFKEGYGPNEQAFRSIKERGFSLIITVDTGIAAVHEAKVAKEL GLDVIITDHHEPGPELPDVRAIVHPKQPGCTYPFKELAGVGVAFKLAHALLGELPDEL LDLAAIGTIADLVPLHDENRLIATLGLERLRRTNRLGLKELIKLSGGDIGEANEETVG FQLAPRLNAVGRIEQADPAVHLLMSEDSFEAEELAAEIDQLNKERQKMVSKMTDEAIE MVEQQGLDQTAIVVAKAGWNPGVVGIVASKLVDRFYRPAIVLGIDEEKGIAKGSARSI RGFNLFESLSECRDILPHFGGHPMAAGMTLKAEDVPDLRSRLNEIADNTLTEEDFIPV QEVDLVCGVEDITVESIAEMNMLSPFGMLNPKPHVLVENAVLEDVRKIGANKTHVKMT IRNESSQLDCVGFNKGELQEGIVPGSRISIVGEMSINEWNNRKKPQLMIKDAAVSEWQ LFDLRGKRTWEDTVSALPSAKRAIVSFKEDSTTLLQTEDLRREVHVISSKDQAKAFDL DGAYIVLLDPPPSLDMLARLLEGKAPERIYFIFLNHEDHFLSTFPARDHFKWYYAFLL KRGAFDVKKHGSELAKHKGWSVETINFMTKVFFDLGFVKIENGVLSVVSGAKKRDLTD SQTYQAKQQLMELDQKLNYSSAEELKEWLNKLMKQDSEAYESTRRT*" /label="recJ CDS" gene complement(2245779..2248139) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /label="recJ gene" promotor_-10 complement(2246243..2246262) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2246251) /Source="Nicolas_upshifts" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2246276..2246285) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-35" promotor_-10 complement(2248153..2248172) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2248164) /Source="Nicolas_upshifts" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2248187..2248193) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2248206..2248529) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390641.1" /db_xref="EnsemblGenomes-Gn:BSU27630" /db_xref="EnsemblGenomes-Tr:CAB14722" /db_xref="GOA:O32045" /db_xref="InterPro:IPR010445" /db_xref="SubtiList:BG13803" /db_xref="UniProtKB/Swiss-Prot:O32045" /translation="MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILV ILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAM IEKKD*" /label="yrvD CDS" gene complement(2248206..2248529) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /label="yrvD gene" promotor_-10 complement(2248550..2248568) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2248561) /Source="Nicolas_upshifts" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2248583..2248589) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-35" CDS complement(2248605..2249102) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative potassium transport accessory component" /protein_id="NP_390642.1" /db_xref="EnsemblGenomes-Gn:BSU27640" /db_xref="EnsemblGenomes-Tr:CAB14723" /db_xref="GOA:O32046" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13802" /db_xref="UniProtKB/Swiss-Prot:O32046" /translation="MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDEND HEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQ TIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKL TAKGA*" /label="yrvC CDS" gene complement(2248605..2249102) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /label="yrvC gene" S_feature complement(2249103..2249178) /Source="Nicolas_S_feature" /locus_tag="new_2826743_2826818_c" /HighExp="Oxctl, HiOs, G180, LBGexp, Paraq, G150, G135, H2O2, MG-0.2, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1046" promotor_-10 complement(2249172..2249191) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-10" upshifts complement(2249178) /Source="Nicolas_upshifts" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="upshifts" promotor_-35 complement(2249205..2249212) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-35" CDS complement(2249260..2251473) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9694879, 15941986, 15995216, 16517687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9694879, 15941986, 15995216, 16517687; Product type t: transporter" /codon_start=1 /transl_table=11 /product="protein-export membrane protein" /protein_id="NP_390643.1" /db_xref="EnsemblGenomes-Gn:BSU27650" /db_xref="EnsemblGenomes-Tr:CAB14724" /db_xref="GOA:O32047" /db_xref="InterPro:IPR005665" /db_xref="InterPro:IPR005791" /db_xref="InterPro:IPR022645" /db_xref="InterPro:IPR022646" /db_xref="InterPro:IPR022813" /db_xref="SubtiList:BG12672" /db_xref="UniProtKB/Swiss-Prot:O32047" /translation="MKKGRLIAFFLFVLLIGTGLGYFTKPAANNITLGLDLQGGFEVL YDVQPVKKGDKITKDVLVSTVEALNRRANVLGVSEPNIQIEGNNRIRVQLAGVTNQNR AREILATEAQLSFRDANDKELLNGADLVENGAKQTYDSTTNEPIVTIKLKDADKFGEV TKKVMKMAPNNQLVIWLDYDKGDSFKKEVQKEHPKFVSAPNVSQELNTTDVKIEGHFT AQEAKDLASILNAGALPVKLTEKYSTSVGAQFGQQALHDTVFAGIVGIAIIFLFMLFY YRLPGLIAVITLSVYIYITLQIFDWMNAVLTLPGIAALILGVGMAVDANIITYERIKE ELKLGKSVRSAFRSGNRRSFATIFDANITTIIAAVVLFIFGTSSVKGFATMLILSILT SFITAVFLSRFLLALLVESRWLDRKKGWFGVNKKHIMDIQDTDENTEPHTPFQKWDFT SKRKYFFIFSSAVTVAGIIILLVFRLNLGIDFASGARIEVQSDHKLTTEQVEKDFESL GMDPDTVVLSGEKSNIGVARFVGVPDKETIAKVKTYFKDKYGSDPNVSTVSPTVGKEL ARNALYAVAIASIGIIIYVSIRFEYKMAIAAIASLLYDAFFIVTFFSITRLEVDVTFI AAILTIIGYSINDTIVTFDRVREHMKKRKPKTFADLNHIVNLSLQQTFTRSINTVLTV VIVVVTLLIFGASSITNFSIALLVGLLTGVYSSLYIAAQIWLAWKGRELKKDSAQ*" /label="secDF CDS" gene complement(2249260..2251473) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /label="secDF gene" downshifts complement(2249265) /Source="Nicolas_upshifts" /id="D1416" /incds=0 /nref=174 /ntot=249 /MaxReadThrough="4.49738" /MaxDrop="5.0013" /score="29.1843057" /energy="-17.8" /TU="U2137" /idTUdmin="U2137" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" promotor_-35 2251032..2251037 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2251051..2251070 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2251059 /Source="Nicolas_upshifts" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2251512..2251808) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19028902, 27059541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19028902, 27059541; Product type r: regulator" /codon_start=1 /transl_table=11 /product="post-transcriptional regulator" /protein_id="NP_390644.1" /db_xref="EnsemblGenomes-Gn:BSU27660" /db_xref="EnsemblGenomes-Tr:CAB14726" /db_xref="GOA:O32049" /db_xref="InterPro:IPR025716" /db_xref="SubtiList:BG13814" /db_xref="UniProtKB/Swiss-Prot:O32049" /translation="MEKHPADLYKDHVRPFLYSKLEEFKILGYDDVELESLWSYLTDK KWKKKTELSIYELASDILSVKIGEFMNYATVESFKTSNWLGSEEGQEALEELLR*" /label="comN CDS" gene complement(2251512..2251808) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /label="comN gene" downshifts 2251719 /Source="Nicolas_upshifts" /id="D1417" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.36122" /MaxDrop="2.33158" /score="-9.07145122" /energy="-8.4" /TU="NA" /idTUdmin="U2136" /TUdmin="-2508" /isTUend="FALSE" /label="downshifts" S_feature complement(2251809..2251887) /Source="Nicolas_S_feature" /locus_tag="new_2829449_2829527_c" /HighExp="LBGtran, Lbtran, C90, M40t45, HiOs, Lbexp, Cold, M0t45, UNK1, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigH" /TUlongPSig=1 /label="S1047" promotor_-35 2251849..2251854 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-35" promotor_-10 2251871..2251889 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-10" promotor_-10 complement(2251873..2251892) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-10" upshifts 2251873 /Source="Nicolas_upshifts" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="upshifts" upshifts complement(2251887) /Source="Nicolas_upshifts" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="upshifts" S_feature complement(2251889..2252807) /Source="Nicolas_S_feature" /locus_tag="new_2829529_2830447_c" /HighExp="S2, M9-stat, Lbstat, BC, T2.0H, T3.0H, T2.30H, T3.30H, Cold, M0t90" /AntisenseName="spoVB" /AntisenseCor="-8.5173616652496897E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1048" promotor_-35 complement(2251907..2251910) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-35" CDS 2251924..2253480 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1744050, 15292147, 15849754, 16850406, 17714441, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744050, 15292147, 15849754, 16850406, 17714441, 19648239; Product type t : transporter" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation); translocase with flippase function for peptidoglycan synthesis" /protein_id="NP_390645.1" /db_xref="EnsemblGenomes-Gn:BSU27670" /db_xref="EnsemblGenomes-Tr:CAB14727" /db_xref="GOA:Q00758" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR014249" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10778" /db_xref="UniProtKB/Swiss-Prot:Q00758" /translation="MAKQTFLKGTLILIAAGMVTRMLGFVNRVVIARFIGEEGVGLYM MAAPTFFLATTLTQFGLPVAISKLVAEASARGDHQKTKNILVMSLTITGVLSLIFTPL FLFFAPVMAETMLTDKRTLYPLLAITPVVPIIAISSVLRGYFQGKQNMNPLAMSQVLE QVVRISLVAVCTTIFLPYGIEYAAAGAMLSSVAGELASLLYLFVCFKYKKTIKIRKHF LQSIKNGKQTFTQLMSVSLPTTGSRFIGNLSWFFEPIVVAQSLAIAGVATVAATKQYG ELTGFAMTLLTLPSFITYSLSTALVPAISEGMEQKKLQVVEYRLEQAMRLCLLSGGIS VVILFVFADELMRVMYGSSGAAVFIKVMAPFFLLYYFQGPLQAVLQALNLAGAAMMNS LIGALVKTGLIFVLATRPSLGIMGAALAIVTGMVLVTLLHAATVSKVLPISIKIKEYA LSFAVIVICGFISSAIKQYISFGASEAVNLAGWIAASAAIYMILLLVFRLIKKDELRR IPIIGRLIIR*" /label="spoVB CDS" gene 2251924..2253480 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /label="spoVB gene" promotor_-10 complement(2252793..2252811) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-10" upshifts complement(2252807) /Source="Nicolas_upshifts" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="upshifts" promotor_-35 complement(2252823..2252831) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-35" S_feature 2253481..2254245 /Source="Nicolas_S_feature" /locus_tag="new_2831121_2831885" /HighExp="S3, BT, S4, LoTm, S7, S8, T5.0H, T4.0H, M9-stat, T3.30H" /AntisenseName="yrbG" /AntisenseCor="0.65629957843767395" /AntisenseRegPval="-33.799999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1049" CDS complement(2253484..2254140) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390646.1" /db_xref="EnsemblGenomes-Gn:BSU27680" /db_xref="EnsemblGenomes-Tr:CAB14728" /db_xref="GOA:O32050" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG13786" /db_xref="UniProtKB/Swiss-Prot:O32050" /translation="MEELLTIAFRTVVLYFVILVIFRFMGKREIGELSILDLVVFIMM AEIAVLAIENVDDHLFHTILPMLVLMIIQVTLAYFSLKNRKVRQLLDGKPTIIIKYGK IDEEAMKSQRYNFDDLMVQLRENSIDRVADVSFAILEPSGKLTIVKKENSGEHRQLEM PLIIDGFIQTENLSRISKDRKWLLESLQKHGYTNPSDISFCSFTDGEIYIDEKDGHRT *" /label="yrbG CDS" gene complement(2253484..2254140) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /label="yrbG gene" promotor_-10 complement(2254159..2254170) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2254171) /Source="Nicolas_upshifts" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2254184..2254190) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2254223..2254228 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2254244..2254262 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2254247 /Source="Nicolas_upshifts" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2254275..2254727 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390647.1" /db_xref="EnsemblGenomes-Gn:BSU27690" /db_xref="EnsemblGenomes-Tr:CAB14729" /db_xref="GOA:O32051" /db_xref="InterPro:IPR023804" /db_xref="SubtiList:BG13815" /db_xref="UniProtKB/Swiss-Prot:O32051" /translation="MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAML LTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSF SLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST*" /label="yrzE CDS" gene 2254275..2254727 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /label="yrzE gene" downshifts 2254711 /Source="Nicolas_upshifts" /id="D1418" /incds=0 /nref=39 /ntot=61 /MaxReadThrough="1.45569" /MaxDrop="7.7199" /score="41.7975947" /energy="-15" /TU="NA" /idTUdmin="U2140" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2254766) /Source="Nicolas_upshifts" /id="D1419" /incds=0 /nref=188 /ntot=281 /MaxReadThrough="2.20451" /MaxDrop="7.91954" /score="33.5938356" /energy="-15" /TU="NA" /idTUdmin="U2141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2254784..2255050) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10974125, 16166550, 21235483, 26790414; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the preprotein translocase" /protein_id="NP_390648.2" /db_xref="EnsemblGenomes-Gn:BSU27700" /db_xref="EnsemblGenomes-Tr:CAB14730" /db_xref="GOA:O32052" /db_xref="InterPro:IPR003849" /db_xref="SubtiList:BG13785" /db_xref="UniProtKB/Swiss-Prot:O32052" /translation="MTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGD SVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE*" /label="yrbF CDS" gene complement(2254784..2255050) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /label="yrbF gene" CDS complement(2255087..2256232) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /EC_number="2.4.2.29" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12123838, 14660578, 16199558, 16206323; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-guanine transglycosylase" /protein_id="NP_390649.1" /db_xref="EnsemblGenomes-Gn:BSU27710" /db_xref="EnsemblGenomes-Tr:CAB14731" /db_xref="GOA:O32053" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /db_xref="InterPro:IPR036511" /db_xref="SubtiList:BG12686" /db_xref="UniProtKB/Swiss-Prot:O32053" /translation="MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLAT VKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQV FSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYD YMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAI GGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTR IARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLR LTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF*" /label="tgt CDS" gene complement(2255087..2256232) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /label="tgt gene" upshifts complement(2255139) /Source="Nicolas_upshifts" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2255183) /Source="Nicolas_upshifts" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2255185..2255204) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2255219..2255224) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2256259..2257287) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /EC_number="2.4.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15822125, 17083917, 10739928" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15822125, 17083917, 10739928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine tRNA ribosyltransferase-isomerase" /protein_id="NP_390650.1" /db_xref="EnsemblGenomes-Gn:BSU27720" /db_xref="EnsemblGenomes-Tr:CAB14732" /db_xref="GOA:O32054" /db_xref="InterPro:IPR003699" /db_xref="InterPro:IPR036100" /db_xref="PDB:1YY3" /db_xref="SubtiList:BG12662" /db_xref="UniProtKB/Swiss-Prot:O32054" /translation="MKVDLFDFELPERLIAQVPLEQRDASRLMVLDKHTGELTDSSFK HIISFFNEGDCLVLNNTRVLPARLFGTKEDTGAKVELLLLKQETGDKWETLAKPAKRV KKGTVVTFGDGRLKAICTEELEHGGRKMEFQYDGIFYEVLESLGEMPLPPYIKEQLDD KERYQTVYSKEIGSAAAPTAGLHFTEEILQQLKDKGVQIEFITLHVGLGTFRPVSADE VEEHNMHAEFYQMSEETAAALNKVRENGGRIISVGTTSTRTLETIAGEHDGQFKASSG WTSIFIYPGYEFKAIDGMITNFHLPKSSLIMLVSALAGRENILRAYNHAVEEEYRFFS FGDAMLII*" /label="queA CDS" gene complement(2256259..2257287) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /label="queA gene" CDS complement(2257317..2257517) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="YP_003097768.1" /db_xref="EnsemblGenomes-Gn:BSU27729" /db_xref="EnsemblGenomes-Tr:CAX52674" /db_xref="GOA:C0H463" /db_xref="InterPro:IPR021320" /db_xref="UniProtKB/Swiss-Prot:C0H463" /translation="MTEFPKIIMILGAVLLIIGAVLHFVGKMPGDIFVKKGNVTFFFP VVTCIIISVVLSILLNLFGRMK*" /label="yrzS CDS" gene complement(2257317..2257517) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /label="yrzS gene" CDS complement(2257510..2258514) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /EC_number="3.1.22.4" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14701911, 15317759, 16267290, 19422832, 21600217, 24770420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase, ATP-dependent component" /protein_id="YP_054590.1" /db_xref="EnsemblGenomes-Gn:BSU27730" /db_xref="EnsemblGenomes-Tr:CAB14733" /db_xref="GOA:O32055" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004605" /db_xref="InterPro:IPR008823" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12669" /db_xref="UniProtKB/Swiss-Prot:O32055" /translation="MDERLVSSEADNHESVIEQSLRPQNLAQYIGQHKVKENLRVFID AAKMRQETLDHVLLYGPPGLGKTTLASIVANEMGVELRTTSGPAIERPGDLAAILTAL EPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATT RVGLLTAPLRDRFGVMSRLEYYTQEELADIVTRTADVFEVEIDKPSALEIARRSRGTP RVANRLLRRVRDFAQVLGDSRITEDISQNALERLQVDRLGLDHIDHKLLMGMIEKFNG GPVGLDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPAVYHHFQMEAPRYD *" /label="ruvB CDS" gene complement(2257510..2258514) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /label="ruvB gene" CDS complement(2258525..2259130) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /EC_number="3.1.22.4" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16267290, 24770420" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16267290, 24770420; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase" /protein_id="NP_390652.1" /db_xref="EnsemblGenomes-Gn:BSU27740" /db_xref="EnsemblGenomes-Tr:CAB14734" /db_xref="GOA:O05392" /db_xref="InterPro:IPR000085" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR011114" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013849" /db_xref="InterPro:IPR036267" /db_xref="SubtiList:BG11973" /db_xref="UniProtKB/Swiss-Prot:O05392" /translation="MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETI FTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENE DEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEAL EALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK*" /label="ruvA CDS" gene complement(2258525..2259130) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /label="ruvA gene" promotor_-10 complement(2259149..2259168) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2259165) /Source="Nicolas_upshifts" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2259167..2259268) /Source="Nicolas_S_feature" /locus_tag="new_2836807_2836908_c" /HighExp="Etha, Heat, S8, S7, S4, S3, S6, S5, Salt, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1050" promotor_-35 complement(2259179..2259185) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2259269..2259781) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10931291, 16049010" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10931291, 16049010; Product type f: factor" /codon_start=1 /transl_table=11 /product="bypass of forespore C, intercompartmental signaling factor" /protein_id="NP_390653.1" /db_xref="EnsemblGenomes-Gn:BSU27750" /db_xref="EnsemblGenomes-Tr:CAB14735" /db_xref="GOA:O05391" /db_xref="InterPro:IPR015050" /db_xref="InterPro:IPR015071" /db_xref="PDB:2BW2" /db_xref="SubtiList:BG11917" /db_xref="UniProtKB/Swiss-Prot:O05391" /translation="MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQ LEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVN GYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFED VIEHMKTYSG*" /label="bofC CDS" gene complement(2259269..2259781) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /label="bofC gene" promotor_-10 complement(2259810..2259821) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-10" upshifts complement(2259825) /Source="Nicolas_upshifts" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="upshifts" CDS complement(2259829..2261136) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099855, 14638426, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative catecholate siderophose exporter" /protein_id="NP_390654.2" /db_xref="EnsemblGenomes-Gn:BSU27760" /db_xref="EnsemblGenomes-Tr:CAB14736" /db_xref="GOA:O05390" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11922" /db_xref="UniProtKB/Swiss-Prot:O05390" /translation="MNTVHAKGNVLNKIGIPSHMVWGYIGVVIFMVGDGLEQGWLSPF LVDHGLSMQQSASLFTMYGIAVTISAWLSGTFVQTWGPRKTMTVGLLAFILGSAAFIG WAIPHMYYPALLGSYALRGLGYPLFAYSFLVWVSYSTSQNILGKAVGWFWFMFTCGLN VLGPFYSSYAVPAFGEINTLWSALLFVAAGGILALFFNKDKFTPIQKQDQPKWKELSK AFTIMFENPKVGIGGVVKTINAIGQFGFAIFLPTYLARYGYSVSEWLQIWGTLFFVNI VFNIIFGAVGDKLGWRNTVMWFGGVGCGIFTLALYYTPQLIGHQYWVLMIIACCYGAA LAGYVPLSALLPTLAPDNKGAAMSVLNLGSGLCAFIAPGIVSLFIGPLGAGGVIWIFA ALYFFSAFLTRFLTISEQSTDVYTEERFVRENVQTNFDKTVKQ*" /label="csbX CDS" gene complement(2259829..2261136) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /label="csbX gene" promotor_-35 complement(2259836..2259842) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-35" downshifts complement(2261090) /Source="Nicolas_upshifts" /id="D1420" /incds=0 /nref=2 /ntot=80 /MaxReadThrough="7.18585" /MaxDrop="3.0235" /score="-6.29978124" /energy="-14.3" /TU="U2145,U2146" /idTUdmin="U2146" /TUdmin="-1793" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2261160..2261178) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-10" upshifts complement(2261175) /Source="Nicolas_upshifts" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="upshifts" promotor_-35 complement(2261193..2261199) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-35" CDS complement(2261207..2262232) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative inositol-related oxidoreductase" /protein_id="NP_390655.1" /db_xref="EnsemblGenomes-Gn:BSU27770" /db_xref="EnsemblGenomes-Tr:CAB14737" /db_xref="GOA:O05389" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR030827" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12280" /db_xref="UniProtKB/Swiss-Prot:O05389" /translation="MTKQIVTGIIGAGRIGKLHVQNISRIPHMKIKAISDIQASRIKS WADSHQIEYITSDYRDLLHDPDIDAIFICSPTAVHAQMIKEAAEAKKHIFCEKPVSFS LDETSEALAAVRKHGVTLQVGFNRRFDPHFKKIKTIVENGEIGTPHLLKITSRDPEPP NIDYVRTSGGLFMDMSIHDFDMARYIMGSEVTEVYAKGAALVNPSFAELGDIDTAVIT LTFENGAMAVIDNSRQAVYGYDQRVEVFGTKGSAAADNSRPTTVEVSTADFVMKDKPH FFFLERYKDSYEEEILRFAEAIGTNQETPCTGNDGLQAGRIARAAQQSLAFGMPVSIE HTEKIAF*" /label="yrbE CDS" gene complement(2261207..2262232) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /label="yrbE gene" promotor_-10 complement(2262269..2262288) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-10" upshifts complement(2262289) /Source="Nicolas_upshifts" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="upshifts" promotor_-35 complement(2262303..2262310) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-35" promotor_-35 2262358..2262365 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2262379..2262398 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2262387 /Source="Nicolas_upshifts" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2262419..2262424 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2262433 /Source="Nicolas_upshifts" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2262440..2262458 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2262470..2263117 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /EC_number="2.7.11.1" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative serine/threonine-protein kinase" /protein_id="NP_390656.2" /db_xref="EnsemblGenomes-Gn:BSU27785" /db_xref="EnsemblGenomes-Tr:CAB14738" /db_xref="GOA:O32057" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13816" /db_xref="UniProtKB/Swiss-Prot:O32057" /translation="MLTKAEALAHTVIYRKNSRFDKVKEKSEELTLIGKGRSAYVFAL TEGGRKMALKVFFPEYQATAVKEAAIYEKLAGSAFYPDIYETGDSFILMEYIKGETFY NCLKKGIAISDDMIQQVEEALSDARAAGLNPSDIHLRNLILTETGAVRVIDVARFEQT KTCTQWDDLKSAYHALYKKPIFPKKIPGFWLEIIAFLYKKDWFQKHFAQRKRKYS*" /label="yrzF CDS" gene 2262470..2263117 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /label="yrzF gene" S_feature complement(2262792..2263125) /Source="Nicolas_S_feature" /locus_tag="new_2840432_2840765_c" /HighExp="LPhT, S8, BI, S7, S6, C30, Sw, BC, Gly, C90" /AntisenseName="yrzF" /AntisenseCor="0.348831504804749" /AntisenseRegPval="-8.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1051" downshifts 2263096 /Source="Nicolas_upshifts" /id="D1421" /incds=0 /nref=29 /ntot=228 /MaxReadThrough="2.4121" /MaxDrop="5.05737" /score="20.8102477" /energy="-18.2" /TU="NA" /idTUdmin="U2147" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(2263127..2263324) /Source="Nicolas_S_feature" /locus_tag="new_2840767_2840964_c" /HighExp="LPhT, BI, B60, S8, Gly, S7, S6, B36, S5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984200000000001" /TUshortSig="Sig-" /TUshortPSig="0.032" /TUlongSig="NA" /TUlongPSig="NA" /label="S1052" CDS complement(2263163..2263285) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513992.1" /db_xref="EnsemblGenomes-Gn:BSU27786" /db_xref="EnsemblGenomes-Tr:CCQ48603" /db_xref="UniProtKB/TrEMBL:L8EAY3" /translation="MEKTYCHSGEKDPEAVYLTVRGYRIKLSPEQMKLISAVRK*" /label="hypothetical protein CDS" gene complement(2263163..2263285) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /label="gene" downshifts complement(2263170) /Source="Nicolas_upshifts" /id="D1422" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="4.39913" /MaxDrop="4.52186" /score="39.5790138" /energy="-18.2" /TU="NA" /idTUdmin="U2149" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2263333) /Source="Nicolas_upshifts" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2263334..2263351) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2263358..2263365) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2263370..2263660 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390658.2" /db_xref="EnsemblGenomes-Gn:BSU27800" /db_xref="EnsemblGenomes-Tr:CAB14740" /db_xref="SubtiList:BG13818" /db_xref="UniProtKB/Swiss-Prot:O32059" /translation="MNPIYSKMREKKGESHIKTENTLSLDAARGELVNEKTLVKRTIY WNYPDSRPAVTWINHNTVKIGNQTLHLDTDETYDWRKDDHWIREEPPQASVR*" /label="yrzH CDS" gene 2263370..2263660 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /label="yrzH gene" misc_feature 2263381..2263400 /Source="Nicolas_upshift_promotors" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2263381..2263528 /Source="Nicolas_S_feature" /locus_tag="new_2841021_2841168" /HighExp="T3.30H, T4.0H, T3.0H, T2.0H, T2.30H, T5.0H, M9-stat, S7, T1.30H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigA" /TUshortPSig="0.903" /TUlongSig="NA" /TUlongPSig="NA" /label="S1053" upshifts 2263381 /Source="Nicolas_upshifts" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="upshifts" CDS 2263667..2263807 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097769.1" /db_xref="EnsemblGenomes-Gn:BSU27809" /db_xref="EnsemblGenomes-Tr:CAX52675" /db_xref="GOA:C0H464" /db_xref="UniProtKB/Swiss-Prot:C0H464" /translation="MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISL PL*" /label="yrzT CDS" gene 2263667..2263807 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /label="yrzT gene" downshifts 2263796 /Source="Nicolas_upshifts" /id="D1423" /incds=0 /nref=139 /ntot=241 /MaxReadThrough="0.64189" /MaxDrop="4.74983" /score="23.2933855" /energy="-9.9" /TU="NA" /idTUdmin="U2150" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2263856..2263862 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2263870..2263970 /Source="Nicolas_upshift_promotors" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2263877..2263895 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2263878 /Source="Nicolas_upshifts" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="upshifts" upshifts 2263930 /Source="Nicolas_upshifts" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="upshifts" CDS 2263971..2265425 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1400476, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium/proton-dependent alanine transporter" /protein_id="NP_390659.2" /db_xref="EnsemblGenomes-Gn:BSU27810" /db_xref="EnsemblGenomes-Tr:CAB14741" /db_xref="GOA:O32060" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG13784" /db_xref="UniProtKB/Swiss-Prot:O32060" /translation="MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMI VQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGA ASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQ SNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSL IIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPA AAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVE AGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAM LGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQ KKQGLDPIFDPKALGIKNADFWEKEYTHESERVS*" /label="alaP CDS" gene 2263971..2265425 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /label="alaP gene" downshifts 2265426 /Source="Nicolas_upshifts" /id="D1424" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="5.01314" /MaxDrop="4.4617" /score="6.86850608" /energy="-10.8" /TU="U2151" /idTUdmin="U2152" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2265466..2266188) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12060744, 18641136, 20647113; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor regulating gene expression" /protein_id="NP_390660.1" /db_xref="EnsemblGenomes-Gn:BSU27820" /db_xref="EnsemblGenomes-Tr:CAB14742" /db_xref="GOA:P94447" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG13783" /db_xref="UniProtKB/Swiss-Prot:P94447" /translation="MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPE ANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECV TDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLE AGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKL ETLIDVLEDDDDVQEVYTNYRS*" /label="yrbC CDS" gene complement(2265466..2266188) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /label="yrbC gene" S_feature 2265471..2265892 /Source="Nicolas_S_feature" /locus_tag="new_2843111_2843532" /HighExp="S8, S6, S7, BT, C30, S5, S4, LoTm, C90, S3" /AntisenseName="yrbC" /AntisenseCor="-8.4330852334841305E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1054" downshifts complement(2265482) /Source="Nicolas_upshifts" /id="D1425" /incds=0 /nref=11 /ntot=164 /MaxReadThrough="3.2014" /MaxDrop="3.66865" /score="23.9031001" /energy="-16" /TU="U2153" /idTUdmin="U2153" /TUdmin="-574" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2266211..2266230) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2266228) /Source="Nicolas_upshifts" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2266244..2266251) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2266291..2266887) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9770294, 10438771, 12562816, 17322312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9770294, 10438771, 12562816, 17322312; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_390661.2" /db_xref="EnsemblGenomes-Gn:BSU27830" /db_xref="EnsemblGenomes-Tr:CAB14743" /db_xref="GOA:P94446" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13782" /db_xref="UniProtKB/Swiss-Prot:P94446" /translation="MGKKMTIASLILMTAGLTACGANDNAMNDTRNNGNTRPIGYYTN ENDADRQGDGIDHDGPVSELMEDQNDGNRNTTNVNNRDRVTADDRVPLATDGTYNNTN NRNMNRNAANNGYDNQENRRLAAKIANRVKQVKNVNDTQVMVSDDRVVIAVKSHREFT KSDRDNVVKAARNYANGRDVQVSTDKGLFRKLHKMNNR*" /label="sgpA CDS" gene complement(2266291..2266887) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /label="sgpA gene" downshifts complement(2266306) /Source="Nicolas_upshifts" /id="D1426" /incds=0 /nref=96 /ntot=172 /MaxReadThrough="2.47709" /MaxDrop="7.18444" /score="23.9031001" /energy="-16" /TU="NA" /idTUdmin="U2154" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2266930..2266941) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2266932) /Source="Nicolas_upshifts" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2266934..2266998) /Source="Nicolas_S_feature" /locus_tag="new_2844574_2844638_c" /HighExp="B36, LoTm, S8, S6, S5, BT, B60, S4, S7, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1055" promotor_-35 complement(2266956..2266962) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2267035..2268198) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10438771, 10714986, 10714992, 11040425, 15901704, 26953338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438771, 10714986, 10714992, 11040425, 15901704, 26953338; Product type f : factor" /codon_start=1 /transl_table=11 /product="morphogenetic protein associated with SpoVID" /protein_id="NP_390662.1" /db_xref="EnsemblGenomes-Gn:BSU27840" /db_xref="EnsemblGenomes-Tr:CAB14744" /db_xref="GOA:O32062" /db_xref="InterPro:IPR014248" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13781" /db_xref="UniProtKB/Swiss-Prot:O32062" /translation="MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMK IKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPP MPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEA MSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPV SPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGA PQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFS APGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE*" /label="safA CDS" gene complement(2267035..2268198) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /label="safA gene" downshifts complement(2267043) /Source="Nicolas_upshifts" /id="D1427" /incds=0 /nref=34 /ntot=189 /MaxReadThrough="5.61903" /MaxDrop="3.9565" /score="38.1347732" /energy="-11.1" /TU="U2155,U2156,U2159" /idTUdmin="U2154" /TUdmin="-749" /isTUend="FALSE" /label="downshifts" S_feature complement(2268199..2268274) /Source="Nicolas_S_feature" /locus_tag="new_2845839_2845914_c" /HighExp="S5, S4, B36, LoTm, S3, B60, S7, S6, Pyr, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1056" promotor_-10 complement(2268250..2268268) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2268274) /Source="Nicolas_upshifts" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2268284..2268289) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2268315..2269421) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /EC_number="2.5.1.72" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15898769, 15937336, 15967443, 18959769, 26455817" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15898769, 15937336, 15967443, 18959769, 26455817; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quinolinate synthetase" /protein_id="NP_390663.1" /db_xref="EnsemblGenomes-Gn:BSU27850" /db_xref="EnsemblGenomes-Tr:CAB14745" /db_xref="GOA:Q9KWZ1" /db_xref="InterPro:IPR003473" /db_xref="InterPro:IPR023515" /db_xref="InterPro:IPR036094" /db_xref="SubtiList:BG12629" /db_xref="UniProtKB/Swiss-Prot:Q9KWZ1" /translation="MSILDVIKQSNDMMPESYKELSRKDMETRVAAIKKKFGSRLFIP GHHYQKDEVIQFADQTGDSLQLAQVAEKNKEADYIVFCGVHFMAETADMLTSEQQTVV LPDMRAGCSMADMADMQQTNRAWKKLQHIFGDTIIPLTYVNSTAEIKAFVGKHGGATV TSSNAKKVLEWAFTQKKRILFLPDQHLGRNTAYDLGIALEDMAVWDPMKDELVAESGH TNVKVILWKGHCSVHEKFTTKNIHDMRERDPDIQIIVHPECSHEVVTLSDDNGSTKYI IDTINQAPAGSKWAIGTEMNLVQRIIHEHPDKQIESLNPDMCPCLTMNRIDLPHLLWS LEQIEKGEPSGVIKVPKAIQEDALLALNRMLSIT*" /label="nadA CDS" gene complement(2268315..2269421) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /label="nadA gene" promotor_-10 complement(2268997..2269015) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2269022) /Source="Nicolas_upshifts" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2269031..2269036) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2269333 /Source="Nicolas_upshifts" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2269334..2269337 /Source="Nicolas_upshift_promotors" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2269408..2270277) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /EC_number="2.4.2.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8419294, 28618168; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)" /protein_id="NP_390664.1" /db_xref="EnsemblGenomes-Gn:BSU27860" /db_xref="EnsemblGenomes-Tr:CAB14746" /db_xref="GOA:P39666" /db_xref="InterPro:IPR002638" /db_xref="InterPro:IPR004393" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022412" /db_xref="InterPro:IPR027277" /db_xref="InterPro:IPR036068" /db_xref="InterPro:IPR037128" /db_xref="SubtiList:BG10868" /db_xref="UniProtKB/Swiss-Prot:P39666" /translation="MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEG IFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLI QRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPP DTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTL SNESVEECCYVNS*" /label="nadC CDS" gene complement(2269408..2270277) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /label="nadC gene" downshifts 2269502 /Source="Nicolas_upshifts" /id="D1428" /incds=1 /nref=4 /ntot=107 /MaxReadThrough="0.495279999999999" /MaxDrop="3.83418" /score="-8.75482157" /energy="-7.4" /TU="NA" /idTUdmin="U2157" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(2270231..2271826) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /EC_number="1.4.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 16199587, 18959769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 16199587, 18959769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-aspartate oxidase" /protein_id="NP_390665.1" /db_xref="EnsemblGenomes-Gn:BSU27870" /db_xref="EnsemblGenomes-Tr:CAB14747" /db_xref="GOA:P38032" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR005288" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10867" /db_xref="UniProtKB/Swiss-Prot:P38032" /translation="MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYA QGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRN ERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDG RCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELT DLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVS RVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGG VSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNR QYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKD ITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKI RKNEGIWNNESFTAEKITESLFS*" /label="nadB CDS" gene complement(2270231..2271826) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /label="nadB gene" promotor_-35 2271854..2271861 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2271854..2271873) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2271875 /Source="Nicolas_upshifts" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2271877..2271896 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2271878) /Source="Nicolas_upshifts" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2271888..2271895) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2271929..2273116 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 14567704, 16199587, 25447671, 26443755, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 14567704, 16199587, 25447671, 26443755, 28882201; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="desulfurase involved in iron-sulfur clusters forNAD biosynthesis" /protein_id="NP_390666.1" /db_xref="EnsemblGenomes-Gn:BSU27880" /db_xref="EnsemblGenomes-Tr:CAB14748" /db_xref="GOA:P38033" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG10866" /db_xref="UniProtKB/Swiss-Prot:P38033" /translation="MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHI LEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIH NCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHL SSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPW KPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIR SLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSE TMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGR QQA*" /label="nifS CDS" gene 2271929..2273116 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /label="nifS gene" promotor_-10 complement(2271930..2271949) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2271948) /Source="Nicolas_upshifts" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2271964..2271973) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2272831..2272836 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2272845 /Source="Nicolas_upshifts" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2272847..2272866 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2273076..2273618 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16199587, 18276644" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16199587, 18276644; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of de novo NAD biosynthesis" /protein_id="NP_390667.2" /db_xref="EnsemblGenomes-Gn:BSU27890" /db_xref="EnsemblGenomes-Tr:CAB14749" /db_xref="GOA:P39667" /db_xref="InterPro:IPR004173" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026043" /db_xref="InterPro:IPR035922" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10865" /db_xref="UniProtKB/Swiss-Prot:P39667" /translation="MTEELKLMGANRRDQLLLWLKESKSPLTGGELAKKANVSRQVIV QDISLLKAKNVPIIATSQGYVYMDAAAQQHQQAERIIACLHGPERTEEELQLIVDEGV TVKDVKIEHPVYGDLTAAIQVGTRKEVSHFIKKINSTNAAYLSQLTDGVHLHTLTAPD EHRIDQACQALEEAGILIKD*" /label="niaR CDS" gene 2273076..2273618 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /label="niaR gene" downshifts 2273601 /Source="Nicolas_upshifts" /id="D1429" /incds=0 /nref=109 /ntot=246 /MaxReadThrough="3.55509" /MaxDrop="5.04771" /score="15.054047" /energy="-5.6" /TU="U2158" /idTUdmin="U2161" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2273643..2274500) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /EC_number="4.2.1.51" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:104661, 114523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104661, 114523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydratase" /protein_id="NP_390668.1" /db_xref="EnsemblGenomes-Gn:BSU27900" /db_xref="EnsemblGenomes-Tr:CAB14750" /db_xref="GOA:P21203" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008242" /db_xref="InterPro:IPR018528" /db_xref="SubtiList:BG10914" /db_xref="UniProtKB/Swiss-Prot:P21203" /translation="MKVGYLGPAATFTHLAVSSCFQNGAEHVAYRTIPECIDAAVAGE VDFAFVPLENALEGSVNLTIDYLIHEQPLPIVGEMTLPIHQHLLVHPSRENAWKELDK IYSHSHAIAQCHKFLHRHFPSVPYEYANSTGAAAKFVSDHPELNIGVIANDMAASTYE LKIVKRDIQDYRDNHTRFVILSPDENISFEVNSKLSSRPKTTLMVMLPQDDQSGALHR VLSAFSWRNLNLSKIESRPTKTGLGHYFFIIDIEKAFDDVLIPGAMQELEALGCKVRL LGAYQSYQL*" /label="pheA CDS" gene complement(2273643..2274500) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /label="pheA gene" S_feature 2273646..2274355 /Source="Nicolas_S_feature" /locus_tag="new_2851286_2851995" /HighExp="S2, T-5.40H, T3.30H, T-4.40H, GM-0.2, GM-0.1, Pyr, T4.0H, T5.0H, GM 10" /AntisenseName="pheA" /AntisenseCor="-0.15664933741609299" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1057" downshifts complement(2273663) /Source="Nicolas_upshifts" /id="D1430" /incds=0 /nref=173 /ntot=247 /MaxReadThrough="1.87872" /MaxDrop="5.15605" /score="13.965695" /energy="-5.6" /TU="NA" /idTUdmin="U2162" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2274517..2274960) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /experiment="publication(s) with functional evidences, PMID:2537815, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2537815, 27260660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of operons hom-thrCB and thrD" /protein_id="NP_390669.1" /db_xref="EnsemblGenomes-Gn:BSU27910" /db_xref="EnsemblGenomes-Tr:CAB14751" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008310" /db_xref="SubtiList:BG10913" /db_xref="UniProtKB/Swiss-Prot:P21204" /translation="MKEETFYLVREDVLPDAMRKTLEVKKLLDRKKADSVADAVQKVD LSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGALSQLLQAVADSGSNVLSIHQT IPLQGRANVTLSISTSAMEEDIHTLMNKLRKFDFVEKVEILGSGA*" /label="thrR CDS" gene complement(2274517..2274960) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /label="thrR gene" CDS complement(2275021..2276307) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ppGpp-binding GTPase involved in cell portioning, DNA repair and ribosome assembly" /protein_id="NP_390670.1" /db_xref="EnsemblGenomes-Gn:BSU27920" /db_xref="EnsemblGenomes-Tr:CAB14752" /db_xref="GOA:P20964" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR006074" /db_xref="InterPro:IPR006169" /db_xref="InterPro:IPR014100" /db_xref="InterPro:IPR015349" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="InterPro:IPR035101" /db_xref="InterPro:IPR036346" /db_xref="InterPro:IPR036726" /db_xref="PDB:1LNZ" /db_xref="SubtiList:BG10337" /db_xref="UniProtKB/Swiss-Prot:P20964" /translation="MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDV VFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQ VIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLAD VGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIE GAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERP QIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEF PLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKR FARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID*" /label="obgE CDS" gene complement(2275021..2276307) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /label="obgE gene" CDS complement(2276341..2276919) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation initiation phosphotransferase" /protein_id="NP_390671.1" /db_xref="EnsemblGenomes-Gn:BSU27930" /db_xref="EnsemblGenomes-Tr:CAB14753" /db_xref="GOA:P06535" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR016122" /db_xref="InterPro:IPR037100" /db_xref="PDB:1F51" /db_xref="PDB:1IXM" /db_xref="PDB:2FTK" /db_xref="SubtiList:BG10336" /db_xref="UniProtKB/Swiss-Prot:P06535" /translation="MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLS LQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKD LSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPS AFDDIRQNGYEDVDIMRFEITSHECLIEIGLD*" /label="spo0B CDS" gene complement(2276341..2276919) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /label="spo0B gene" S_feature complement(2276920..2276985) /Source="Nicolas_S_feature" /locus_tag="new_2854560_2854625_c" /HighExp="Cold, H2O2, G135, Paraq, G180, Oxctl, G150, C30, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigEF" /TUlongPSig=1 /label="S1058" promotor_-10 complement(2276970..2276989) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2276985) /Source="Nicolas_upshifts" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2276987..2277204) /Source="Nicolas_S_feature" /locus_tag="new_2854627_2854844_c" /HighExp="Cold, G135, H2O2, Paraq, G180, Oxctl, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1059" CDS 2276997..2277119 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513993.1" /translation="MLEKQLFFPEISCSFFLALVDLQPGRTFYVLLLGEHIQWV*" /label="hypothetical protein CDS" gene 2276997..2277119 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /label="gene" promotor_-35 complement(2277003..2277010) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2277240..2277524) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 (BL24)" /protein_id="NP_390672.1" /db_xref="EnsemblGenomes-Gn:BSU27940" /db_xref="EnsemblGenomes-Tr:CAB14754" /db_xref="GOA:P05657" /db_xref="InterPro:IPR001684" /db_xref="InterPro:IPR018261" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10335" /db_xref="UniProtKB/Swiss-Prot:P05657" /translation="MLRLDLQFFASKKGVGSTKNGRDSEAKRLGAKRADGQFVTGGSI LYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPVAQ*" /label="rpmA CDS" gene complement(2277240..2277524) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /label="rpmA gene" downshifts complement(2277249) /Source="Nicolas_upshifts" /id="D1431" /incds=0 /nref=212 /ntot=261 /MaxReadThrough="7.39131" /MaxDrop="7.26483" /score="32.4992871" /energy="-12.5" /TU="U2163" /idTUdmin="U2164" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" CDS complement(2277537..2277875) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11567142, 22333191, 25388641, 27435445, 28187498; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 specific N-terminal end cysteine protease" /protein_id="NP_390673.2" /db_xref="EnsemblGenomes-Gn:BSU27950" /db_xref="EnsemblGenomes-Tr:CAB14755" /db_xref="InterPro:IPR007422" /db_xref="InterPro:IPR036764" /db_xref="SubtiList:BG10334" /db_xref="UniProtKB/Swiss-Prot:P26942" /translation="MIQATIRRSHDKGILSFEMTGHANFAEHGQDLVCAGVTAVVFGA VNAVIVLAGFEPLLDIGEDGGYFYFEFPESLDPEARQKAQLLIEGMIVSLETIERDYK DNLRVTTNII*" /label="rppA CDS" gene complement(2277537..2277875) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /label="rppA gene" CDS complement(2277878..2278186) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8223574, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8223574, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L21 (BL20)" /protein_id="NP_390674.1" /db_xref="EnsemblGenomes-Gn:BSU27960" /db_xref="EnsemblGenomes-Tr:CAB14756" /db_xref="GOA:P26908" /db_xref="InterPro:IPR001787" /db_xref="InterPro:IPR018258" /db_xref="InterPro:IPR028909" /db_xref="InterPro:IPR036164" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10333" /db_xref="UniProtKB/Swiss-Prot:P26908" /translation="MYAIIKTGGKQIKVEEGQTVYIEKLAAEAGETVTFEDVLFVGGD NVKVGNPTVEGATVTAKVEKQGRAKKITVFRYKPKKNVHKKQGHRQPYTKVTIEKINA *" /label="rplU CDS" gene complement(2277878..2278186) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /label="rplU gene" misc_RNA complement(2278200..2278275) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /product="ribosomal protein L21 leader mRNA sequence" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27381917" /label="ldlU RNA" gene complement(2278200..2278275) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /label="ldlU gene" promotor_-10 complement(2278287..2278306) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2278307) /Source="Nicolas_upshifts" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2278320..2278327) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2278333..2279199) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /EC_number="3.4.24.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease [proteolysis of pro-sigma(K)]" /protein_id="NP_390675.1" /db_xref="EnsemblGenomes-Gn:BSU27970" /db_xref="EnsemblGenomes-Tr:CAB14757" /db_xref="GOA:P26937" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG10332" /db_xref="UniProtKB/Swiss-Prot:P26937" /translation="MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHE LGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAW MLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNL KTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKN RELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKR TNSSMEELLLPY*" /label="spoIVFB CDS" gene complement(2278333..2279199) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /label="spoIVFB gene" CDS complement(2279192..2279986) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpoIVFB (stage IV sporulation)" /protein_id="NP_390676.1" /db_xref="EnsemblGenomes-Gn:BSU27980" /db_xref="EnsemblGenomes-Tr:CAB14758" /db_xref="GOA:P26936" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG10331" /db_xref="UniProtKB/Swiss-Prot:P26936" /translation="MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTD QEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIK PAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQ DFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVD VALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE*" /label="spoIVFA CDS" gene complement(2279192..2279986) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /label="spoIVFA gene" downshifts 2279989 /Source="Nicolas_upshifts" /id="D1432" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="1.00279" /MaxDrop="2.6024" /score="-6.66807377" /energy="-6.9" /TU="NA" /idTUdmin="U2165" /TUdmin="-131" /isTUend="FALSE" /label="downshifts" promotor_no_box 2279995..2280095 /Source="Nicolas_upshift_promotors" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(2280010..2280028) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-10" upshifts complement(2280021) /Source="Nicolas_upshifts" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="upshifts" promotor_-35 complement(2280044..2280049) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-35" upshifts 2280055 /Source="Nicolas_upshifts" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2280098 /Source="Nicolas_upshifts" /id="D1433" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="1.68429" /MaxDrop="7.01891" /score="-6.66807377" /energy="-6.9" /TU="U2165" /idTUdmin="U2165" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(2280133) /Source="Nicolas_upshifts" /id="D1434" /incds=0 /nref=236 /ntot=262 /MaxReadThrough="2.68001" /MaxDrop="5.80551" /score="40.3102023" /energy="-12.6" /TU="U2166" /idTUdmin="U2167" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2280136..2280942) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase activator of MinC" /protein_id="NP_390677.1" /db_xref="EnsemblGenomes-Gn:BSU27990" /db_xref="EnsemblGenomes-Tr:CAB14759" /db_xref="GOA:Q01464" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10330" /db_xref="UniProtKB/Swiss-Prot:Q01464" /translation="MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLR NLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQ IKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLL EQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGE PIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS*" /label="minD CDS" gene complement(2280136..2280942) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /label="minD gene" CDS complement(2280944..2281624) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division regulator (septum placement)" /protein_id="NP_390678.1" /db_xref="EnsemblGenomes-Gn:BSU28000" /db_xref="EnsemblGenomes-Tr:CAB14760" /db_xref="GOA:Q01463" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /db_xref="InterPro:IPR036145" /db_xref="PDB:2M4I" /db_xref="SubtiList:BG10329" /db_xref="UniProtKB/Swiss-Prot:Q01463" /translation="MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQY TDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREE AEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNN QAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPD LTRLEGGM*" /label="minC CDS" gene complement(2280944..2281624) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /label="minC gene" CDS complement(2281677..2282195) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 18156271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 18156271; Product type s: structure" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390679.1" /db_xref="EnsemblGenomes-Gn:BSU28010" /db_xref="EnsemblGenomes-Tr:CAB14761" /db_xref="GOA:Q01467" /db_xref="InterPro:IPR007227" /db_xref="SubtiList:BG10328" /db_xref="UniProtKB/Swiss-Prot:Q01467" /translation="MKRFLLPFVMMLVFSAESIFTDLVHFPFVTDDQVLAPRFLMLVL IFMSAFINQKHAMIYGFIFGFLYDMNYTSLLGVYMFGFAGLCYLASKAFKVLHTNAFV VILIAVLAVCLLEFYVFGIQSLIHKDIMTFNGFVLDRFIPTILLNIAAALILVLPFRL FFMSLKKELRDE*" /label="mreD CDS" gene complement(2281677..2282195) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /label="mreD gene" CDS complement(2282192..2283064) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 17427287, 20623345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 17427287, 20623345; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390680.2" /db_xref="EnsemblGenomes-Gn:BSU28020" /db_xref="EnsemblGenomes-Tr:CAB14762" /db_xref="GOA:Q01466" /db_xref="InterPro:IPR007221" /db_xref="SubtiList:BG10327" /db_xref="UniProtKB/Swiss-Prot:Q01466" /translation="MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVF QNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDE LGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKS SGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDK QDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVV NRDVPTVDTEEEGS*" /label="mreC CDS" gene complement(2282192..2283064) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /label="mreC gene" CDS complement(2283095..2284108) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390681.2" /db_xref="EnsemblGenomes-Gn:BSU28030" /db_xref="EnsemblGenomes-Tr:CAB14763" /db_xref="GOA:Q01465" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10326" /db_xref="UniProtKB/Swiss-Prot:Q01465" /translation="MFGIGARDLGIDLGTANTLVFVKGKGIVVREPSVVALQTDTKSI VAVGNDAKNMIGRTPGNVVALRPMKDGVIADYETTATMMKYYINQAIKNKGMFARKPY VMVCVPSGITAVEERAVIDATRQAGARDAYPIEEPFAAAIGANLPVWEPTGSMVVDIG GGTTEVAIISLGGIVTSQSIRVAGDEMDDAIINYIRKTYNLMIGDRTAEAIKMEIGSA EAPEESDNMEIRGRDLLTGLPKTIEITGKEISNALRDTVSTIVEAVKSTLEKTPPELA ADIMDRGIVLTGGGALLRNLDKVISEETKMPVLIAEDPLDCVAIGTGKALEHIHLFKG KTR*" /label="mreB CDS" gene complement(2283095..2284108) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /label="mreB gene" upshifts complement(2284149) /Source="Nicolas_upshifts" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2284161..2284179) /Source="Nicolas_upshift_promotors" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2284200..2284895) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10652786, 17434969, 18556794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved nucleotide-related metabolism protein" /protein_id="NP_390682.1" /db_xref="EnsemblGenomes-Gn:BSU28040" /db_xref="EnsemblGenomes-Tr:CAB14764" /db_xref="GOA:Q02170" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR001405" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR020891" /db_xref="InterPro:IPR025657" /db_xref="SubtiList:BG10325" /db_xref="UniProtKB/Swiss-Prot:Q02170" /translation="MVIHDLPLKLKDFPMKEKPRERLLKVGAENLANHELLAILLRTG TKHESVLDLSNRLLRSFDGLRLLKEASVEELSSIPGIGMVKAIQILAAVELGSRIHKL ANEEHFVIRSPEDGANLVMEDMRFLTQEHFVCLYLNTKNQVIHKRTVFIGSLNSSIVH PREVFKEAFKRSAASFICVHNHPSGDPTPSREDIEVTRRLFECGNLIGIELLDHLVIG DKKFVSLKEKGYL*" /label="ysxA CDS" gene complement(2284200..2284895) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /label="ysxA gene" CDS complement(2284932..2285501) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /EC_number="3.6.1.9" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10841541, 16216582, 21564336, 24210219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10841541, 16216582, 21564336, 24210219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside triphosphate pyrophosphatase; septum formation DNA-binding protein (multicopy associated filamentation)" /protein_id="NP_390683.1" /db_xref="EnsemblGenomes-Gn:BSU28050" /db_xref="EnsemblGenomes-Tr:CAB14765" /db_xref="GOA:Q02169" /db_xref="InterPro:IPR003697" /db_xref="InterPro:IPR029001" /db_xref="PDB:1EX2" /db_xref="PDB:1EXC" /db_xref="PDB:4HEB" /db_xref="SubtiList:BG10324" /db_xref="UniProtKB/Swiss-Prot:Q02169" /translation="MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEE NVQWLAKQKAKAVADLHPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHS VITAVSIQAENHSETFYDKTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFV KKIDGDYYSVMGLPISKTMRALRHFDIRA*" /label="maf CDS" gene complement(2284932..2285501) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /label="maf gene" promotor_-10 complement(2285353..2285368) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2285362) /Source="Nicolas_upshifts" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2285381..2285390) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2285540..2285559) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2285556) /Source="Nicolas_upshifts" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2285573..2285579) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2285652) /Source="Nicolas_upshifts" /id="D1435" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="1.92542" /MaxDrop="5.77117" /score="8.94061802" /energy="-7.4" /TU="NA" /idTUdmin="U2169" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2285654..2286652) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16959571, 17376078, 22720735, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16959571, 17376078, 22720735, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spatial and temporal regulator of the dissolution of septal peptidoglycan during engulfment (stage II sporulation)" /protein_id="NP_390684.1" /db_xref="EnsemblGenomes-Gn:BSU28060" /db_xref="EnsemblGenomes-Tr:CAB14766" /db_xref="GOA:P37575" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10912" /db_xref="UniProtKB/Swiss-Prot:P37575" /translation="MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTF SNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKT GAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSA DKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYT YVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILD EDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK*" /label="spoIIB CDS" gene complement(2285654..2286652) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /label="spoIIB gene" promotor_-10 complement(2286699..2286718) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2286707) /Source="Nicolas_upshifts" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2286730..2286737) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2286775) /Source="Nicolas_upshifts" /id="D1436" /incds=0 /nref=1 /ntot=56 /MaxReadThrough="3.18314" /MaxDrop="2.89774" /score="11.209969" /energy="-7.6" /TU="U2170" /idTUdmin="U2170" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS complement(2286786..2287532) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /EC_number="3.4.23.43" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2553669, 9723928, 15849754, 16751195, 16850406, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2553669, 9723928, 15849754, 16751195, 16850406, 16751195; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane prepilin peptidase" /protein_id="NP_390685.2" /db_xref="EnsemblGenomes-Gn:BSU28070" /db_xref="EnsemblGenomes-Tr:CAB14767" /db_xref="GOA:P15378" /db_xref="InterPro:IPR000045" /db_xref="InterPro:IPR010627" /db_xref="SubtiList:BG10323" /db_xref="UniProtKB/Swiss-Prot:P15378" /translation="MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLT PAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVF ISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPL PFAPAIAAGSILAYLYGDSIISFYIKMALG*" /label="comC CDS" gene complement(2286786..2287532) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /label="comC gene" promotor_-10 complement(2287560..2287579) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2287567) /Source="Nicolas_upshifts" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2287594..2287601) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2287672..2288964) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /EC_number="6.3.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2105929, 2985605, 3040739, 6994831, 9098041, 15705579, 22720735, 26443588; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="folyl-polyglutamate synthase" /protein_id="NP_390686.1" /db_xref="EnsemblGenomes-Gn:BSU28080" /db_xref="EnsemblGenomes-Tr:CAB14768" /db_xref="GOA:Q05865" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10322" /db_xref="UniProtKB/Swiss-Prot:Q05865" /translation="MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAF HVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVN QMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEP LLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHA APFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEW LNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRF ANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSW SEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK*" /label="folC CDS" gene complement(2287672..2288964) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /label="folC gene" downshifts complement(2287677) /Source="Nicolas_upshifts" /id="D1437" /incds=0 /nref=1 /ntot=121 /MaxReadThrough="1.66565" /MaxDrop="3.18428" /score="24.7086033" /energy="-14.3" /TU="NA" /idTUdmin="U2171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2288965..2289023) /Source="Nicolas_S_feature" /locus_tag="new_2866605_2866663_c" /HighExp="S0, LBGexp, G150, MG 45, G135, G180, Gly, Oxctl, M0t45, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1060" CDS complement(2289024..2291666) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /EC_number="6.1.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9098041, 11114335, 25310979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 11114335, 25310979; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="valyl-tRNA synthetase" /protein_id="NP_390687.2" /db_xref="EnsemblGenomes-Gn:BSU28090" /db_xref="EnsemblGenomes-Tr:CAB14769" /db_xref="GOA:Q05873" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002303" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR019499" /db_xref="InterPro:IPR033705" /db_xref="InterPro:IPR037118" /db_xref="SubtiList:BG10321" /db_xref="UniProtKB/Swiss-Prot:Q05873" /translation="METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSV VIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLR EEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVR EVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIE IATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAV KITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAG VLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRF EKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLD TWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERP FKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSY EKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ LADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMR LLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNI RSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTA VVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDE EREKEKDYVAKRDAVQKRMAELKG*" /label="valS CDS" gene complement(2289024..2291666) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /label="valS gene" S_feature complement(2291667..2291725) /Source="Nicolas_S_feature" /locus_tag="new_2869307_2869365_c" /HighExp="G150, G180, LBGexp, Oxctl, G135, dia0, HPh, Lbexp, Paraq, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigEF" /TUshortPSig="1, 0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1061" misc_RNA complement(2291726..2291948) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /product="T-box riboswitch specific of valine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboV RNA" gene complement(2291726..2291948) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /label="tboV gene" downshifts complement(2291769) /Source="Nicolas_upshifts" /id="D1438" /incds=0 /nref=9 /ntot=27 /MaxReadThrough="6.76593" /MaxDrop="4.53149" /score="23.9897385" /energy="-20" /TU="U2171,U2173,U2176" /idTUdmin="U2176" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2291977..2291996) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2291989) /Source="Nicolas_upshifts" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2291991..2292099) /Source="Nicolas_S_feature" /locus_tag="new_2869631_2869739_c" /HighExp="S8, S6, S7, S5, B36, LoTm, S4, S3, BT, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigEF" /TUshortPSig="0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1062" promotor_-35 complement(2292011..2292016) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2292053..2292062 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2292075..2292094 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2292076 /Source="Nicolas_upshifts" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2292092..2292106) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2292099) /Source="Nicolas_upshifts" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2292114..2292118) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2292114..2292305 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097770.1" /db_xref="EnsemblGenomes-Gn:BSU28099" /db_xref="EnsemblGenomes-Tr:CAX52676" /db_xref="GOA:C0H465" /db_xref="UniProtKB/Swiss-Prot:C0H465" /translation="MKKRFSSYSLPPWVRQIRLVSAQVIIPITIFQGIRTIFFPTTFD VLLLAILIFLACALHLEWI*" /label="yszA CDS" gene 2292114..2292305 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /label="yszA gene" CDS complement(2292324..2293349) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16371471, 16390444, 22091839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16371471, 16390444, 22091839; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390688.1" /db_xref="EnsemblGenomes-Gn:BSU28100" /db_xref="EnsemblGenomes-Tr:CAB14770" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014253" /db_xref="SubtiList:BG10347" /db_xref="UniProtKB/Swiss-Prot:P37964" /translation="MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGR GKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQK HAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLS PFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGT GYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFL SYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQ AENESTS*" /label="cotN CDS" gene complement(2292324..2293349) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /label="cotN gene" downshifts complement(2292354) /Source="Nicolas_upshifts" /id="D1439" /incds=0 /nref=23 /ntot=70 /MaxReadThrough="4.44965" /MaxDrop="6.68961" /score="-7.46388093" /energy="-12.1" /TU="U2176" /idTUdmin="U2176" /TUdmin="-1311" /isTUend="FALSE" /label="downshifts" CDS complement(2293382..2295109) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11325931, 16371471, 16950916, 22773792, 23178679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325931, 16371471, 16950916, 22773792, 23178679; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenetic spore protein (stage VI sporulation)" /protein_id="NP_390689.1" /db_xref="EnsemblGenomes-Gn:BSU28110" /db_xref="EnsemblGenomes-Tr:CAB14771" /db_xref="GOA:P37963" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10346" /db_xref="UniProtKB/Swiss-Prot:P37963" /translation="MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYV SIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKV SHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEE LSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESV ASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAE PAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYA LRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNA DLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIE VRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYL TKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILY IPQYKNSHA*" /label="spoVID CDS" gene complement(2293382..2295109) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /label="spoVID gene" promotor_-35 2294711..2294714 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2294730..2294749 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2294736 /Source="Nicolas_upshifts" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2295105..2295109 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2295118..2295132 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2295132 /Source="Nicolas_upshifts" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2295147..2295165) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-10" upshifts complement(2295163) /Source="Nicolas_upshifts" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="upshifts" promotor_-35 complement(2295181..2295186) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-35" CDS complement(2295240..2296532) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 12029044, 15802251, 16682782, 20946885, 27303897" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 12029044, 15802251, 16682782, 20946885, 27303897; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde 2,1-aminomutase" /protein_id="NP_390690.1" /db_xref="EnsemblGenomes-Gn:BSU28120" /db_xref="EnsemblGenomes-Tr:CAB14772" /db_xref="GOA:P30949" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3BS8" /db_xref="SubtiList:BG10345" /db_xref="UniProtKB/Swiss-Prot:P30949" /translation="MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKG SKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLV IDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGV ATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPP QEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPV GAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLE EGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGV FLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR*" /label="hemL CDS" gene complement(2295240..2296532) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /label="hemL gene" downshifts complement(2295257) /Source="Nicolas_upshifts" /id="D1440" /incds=0 /nref=144 /ntot=397 /MaxReadThrough="3.40168" /MaxDrop="7.29251" /score="3.77738386" /energy="-10.6" /TU="NA" /idTUdmin="U2177" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2296562..2297536) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /EC_number="4.2.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 12029044, 15802251, 20823524, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 12029044, 15802251, 20823524, 24598743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" /protein_id="NP_390691.1" /db_xref="EnsemblGenomes-Gn:BSU28130" /db_xref="EnsemblGenomes-Tr:CAB14773" /db_xref="GOA:P30950" /db_xref="InterPro:IPR001731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR030656" /db_xref="SubtiList:BG10344" /db_xref="UniProtKB/Swiss-Prot:P30950" /translation="MSQSFNRHRRLRTSKAMREMVKETRLHPSDFIYPIFVVEGLEGK KAVPSMPDVHHVSLDLLKDEVAELVKLGIQSVIVFGIPEEKDDCGTQAYHDHGIVQKA ITEIKEHFPEMVVVADTCLCEYTDHGHCGLVKDGVILNDESLELLAQTAVSQAKAGAD IIAPSNMMDGFVTVIREALDKEGFVNIPIMSYAVKYSSEFYGPFRDAANSTPQFGDRK TYQMDPANRMEALREAQSDVEEGADFLIVKPSLSYMDIMRDVKNEFTLPLVAYNVSGE YSMVKAAAQNGWIKEKEIVLEILTSMKRAGADLIITYHAKDAAKWLAE*" /label="hemB CDS" gene complement(2296562..2297536) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /label="hemB gene" CDS complement(2297533..2298321) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /EC_number="4.2.1.75" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 2110138, 7628476, 12029044, 12196144, 15802251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 2110138, 7628476, 12029044, 12196144, 15802251; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III cosynthase" /protein_id="NP_390692.1" /db_xref="EnsemblGenomes-Gn:BSU28140" /db_xref="EnsemblGenomes-Tr:CAB14774" /db_xref="GOA:P21248" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG10343" /db_xref="UniProtKB/Swiss-Prot:P21248" /translation="MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFR RALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTAR RLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTA CISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI*" /label="hemD CDS" gene complement(2297533..2298321) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /label="hemD gene" CDS complement(2298311..2299255) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /EC_number="2.5.1.61" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 9058548, 12029044, 15802251, 23908040, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 9058548, 12029044, 15802251, 23908040, 24598743; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="porphobilinogen deaminase (hydroxymethylbilane synthase)" /protein_id="NP_390693.1" /db_xref="EnsemblGenomes-Gn:BSU28150" /db_xref="EnsemblGenomes-Tr:CAB14775" /db_xref="GOA:P16616" /db_xref="InterPro:IPR000860" /db_xref="InterPro:IPR022417" /db_xref="InterPro:IPR022418" /db_xref="InterPro:IPR022419" /db_xref="InterPro:IPR036803" /db_xref="SubtiList:BG10342" /db_xref="UniProtKB/Swiss-Prot:P16616" /translation="MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKG DRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPERED PRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLET EDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQ FTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKET VTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK*" /label="hemC CDS" gene complement(2298311..2299255) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /label="hemC gene" CDS complement(2299288..2300118) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8012594, 12029044, 15802251, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012594, 12029044, 15802251, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="negative effector of the concentration of glutamyl-tRNA reductase HemA" /protein_id="NP_390694.2" /db_xref="EnsemblGenomes-Gn:BSU28160" /db_xref="EnsemblGenomes-Tr:CAB14776" /db_xref="GOA:P16645" /db_xref="InterPro:IPR002541" /db_xref="SubtiList:BG10341" /db_xref="UniProtKB/Swiss-Prot:P16645" /translation="MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLS IVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNV IGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQY HLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFD AKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS *" /label="hemX CDS" gene complement(2299288..2300118) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /label="hemX gene" CDS complement(2300126..2301493) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /EC_number="1.2.1.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1536660, 15802251, 1672867, 2490162, 12029044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1536660, 15802251, 1672867, 2490162, 12029044; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA reductase" /protein_id="NP_390695.1" /db_xref="EnsemblGenomes-Gn:BSU28170" /db_xref="EnsemblGenomes-Tr:CAB14777" /db_xref="GOA:P16618" /db_xref="InterPro:IPR000343" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR015895" /db_xref="InterPro:IPR015896" /db_xref="InterPro:IPR018214" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036343" /db_xref="InterPro:IPR036453" /db_xref="SubtiList:BG10340" /db_xref="UniProtKB/Swiss-Prot:P16618" /translation="MHILVVGVDYKSAPIEIREKVSFQPNELAEAMVQLKEEKSILEN IIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLSKEELSPFLTFYESDAAVEHLFR VACGLDSMVIGETQILGQVRDSFKTAQQEKTIGTIFNELFKQAVTVGKRTHAETDIGS NAVSVSYAAVELAKKIFGNLSSKHILILGAGKMGELAAENLHGQGIGKVTVINRTYLK AKELADRFSGEARSLNQLESALAEADILISSTGASEFVVSKEMMENANKLRKGRPLFM VDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANMKERRETAEKVELLIEETIVEFKQ WMNTLGVVPVISALREKALAIQSETMDSIERKLPHLSTREKKLLNKHTKSIINQMLRD PILKVKELAADADSEEKLALFMQIFDIEEAAGRQMMKTVESSQKVHSFKKAESKAGFS PLVSE*" /label="hemA CDS" gene complement(2300126..2301493) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /label="hemA gene" misc_feature complement(2301557..2301576) /Source="Nicolas_upshift_promotors" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2301563) /Source="Nicolas_upshifts" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2301565..2301654) /Source="Nicolas_S_feature" /locus_tag="new_2879205_2879294_c" /HighExp="dia15, Salt, dia5, Etha, Paraq, H2O2, Diami, Heat, LoTm, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigGF" /TUshortPSig="0.997, 1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1063" misc_feature 2301614..2301633 /Source="Nicolas_upshift_promotors" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2301622 /Source="Nicolas_upshifts" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2301651..2301670) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2301654) /Source="Nicolas_upshifts" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2301656..2302072) /Source="Nicolas_S_feature" /locus_tag="new_2879296_2879712_c" /HighExp="Etha, S5, Gly, S7, S4, S8, S6, H2O2, dia15, G135" /AntisenseName="ysxD" /AntisenseCor="-1.16761021676615E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF" /TUshortPSig="1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1064" promotor_-35 complement(2301681..2301689) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2301723..2302220 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390696.2" /db_xref="EnsemblGenomes-Gn:BSU28180" /db_xref="EnsemblGenomes-Tr:CAB14778" /db_xref="GOA:P40736" /db_xref="SubtiList:BG11068" /db_xref="UniProtKB/Swiss-Prot:P40736" /translation="MKQKSILFPCLLLAASVYAWLESGQAELFSGQDQWPVLLMLLGA AFVYQGKKEAVTPHFFIGLLLFGIGLHFFAKPKWVWWPDDFEMLLFMIGFSLLVSTVQ KKEYVYEAVSMICFSLFLYFFKQIMAWLESAHIPTALLKEYWPFVFIGISLLLLLIKR KKSIR*" /label="ysxD CDS" gene 2301723..2302220 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /label="ysxD gene" promotor_-10 complement(2302056..2302074) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2302072) /Source="Nicolas_upshifts" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2302074..2302204) /Source="Nicolas_S_feature" /locus_tag="new_2879714_2879844_c" /HighExp="S5, S4, S8, S6, H2O2, S7, Etha, dia15, Diami, G180" /AntisenseName="ysxD" /AntisenseCor="-1.18079537254433E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1065" promotor_-35 complement(2302090..2302096) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2302184..2302195) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-10" upshifts complement(2302204) /Source="Nicolas_upshifts" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="upshifts" promotor_-35 complement(2302210..2302216) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-35" CDS complement(2302242..2302829) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome 50S subunit assembly(maturation of the central 50S protuberance)" /protein_id="NP_390697.1" /db_xref="EnsemblGenomes-Gn:BSU28190" /db_xref="EnsemblGenomes-Tr:CAB14779" /db_xref="GOA:P38424" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019987" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030393" /db_xref="PDB:1SUL" /db_xref="PDB:1SVI" /db_xref="PDB:1SVW" /db_xref="SubtiList:BG10339" /db_xref="UniProtKB/Swiss-Prot:P38424" /translation="MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLI NRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITT REELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVR QTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR*" /label="engB CDS" gene complement(2302242..2302829) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /label="engB gene" downshifts complement(2302270) /Source="Nicolas_upshifts" /id="D1441" /incds=0 /nref=78 /ntot=212 /MaxReadThrough="4.03888" /MaxDrop="6.16077" /score="19.8235959" /energy="-13.4" /TU="NA" /idTUdmin="U2182" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2302826..2305150) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /EC_number="3.4.21.53" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="class III heat-shock ATP-dependent LonA protease" /protein_id="NP_390698.1" /db_xref="EnsemblGenomes-Gn:BSU28200" /db_xref="EnsemblGenomes-Tr:CAB14780" /db_xref="GOA:P37945" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027543" /db_xref="PDB:1X37" /db_xref="PDB:3M65" /db_xref="PDB:3M6A" /db_xref="SubtiList:BG10338" /db_xref="UniProtKB/Swiss-Prot:P37945" /translation="MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMH DHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYN EHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP GRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRS MERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRY EKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILE YLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGH RRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSF SDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPK QIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRI TVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLIL TGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITM ATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEK DIEDIPESVREGLTFILASHLDEVLEHALVGEKK*" /label="lonA CDS" gene complement(2302826..2305150) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /label="lonA gene" S_feature complement(2305151..2305262) /Source="Nicolas_S_feature" /locus_tag="new_2882791_2882902_c" /HighExp="Etha, dia15, LBGtran, dia5, Diami, H2O2, LBGexp, Lbexp, LoTm, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.967" /TUlongSig="NA" /TUlongPSig="NA" /label="S1066" promotor_-10 complement(2305247..2305266) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2305262) /Source="Nicolas_upshifts" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2305280..2305287) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2305331..2306989) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 18689473, 26428922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 18689473, 26428922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific ATP-dependent protease LonB" /protein_id="NP_390699.1" /db_xref="EnsemblGenomes-Gn:BSU28210" /db_xref="EnsemblGenomes-Tr:CAB14781" /db_xref="GOA:P42425" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014251" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11077" /db_xref="UniProtKB/Swiss-Prot:P42425" /translation="MSWTGIALFIQLFFGIIIGLYFWNLLKNQRTQKVTIDKESKKEM EQLRKMRAISLSEPLSEKVRPKSFKDIVGQEDGIKALKAALCGPNPQHVIVYGPPGVG KTAAARLVLEEAKKHKQSPFKEQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEE NTQIPNHIHDIFQNGLPADFRLIGATTRMPNEIPPAIRSRCLEVFFRELEKDELKTVA KTAADKIEKNISEEGLDLLTSYTRNGREAVNMIQIAAGMAVTENRKDITIEDIEWVIH SSQLTPKHEQKIGVEPQVGIVNGLAVYGPNSGSLLEIEVSVTAAQDKGSINITGIAEE ESIGSQSKSIRRKSMAKGSVENVLTVLRTMGMKPSDYDIHINFPGGIPIDGPSAGIAM AAGIFSAIHKIPIDNTVAMTGEISLNGLVKPIGGVIPKIKAAKQSGAKKVIIPYENQQ AILKQIDGIEIIAVKTFQEVLDEILVNPPTEQKPFHIEINKESV*" /label="lonB CDS" gene complement(2305331..2306989) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /label="lonB gene" downshifts complement(2305350) /Source="Nicolas_upshifts" /id="D1442" /incds=0 /nref=24 /ntot=42 /MaxReadThrough="2.32825" /MaxDrop="4.82102" /score="7.30551887" /energy="-7.1" /TU="NA" /idTUdmin="U2183" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2307033..2307051) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2307044) /Source="Nicolas_upshifts" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2307067..2307072) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2307141..2308403) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein unfolding ATPase required for presentation of proteins to proteases; Maxwell's demon" /protein_id="NP_390700.2" /db_xref="EnsemblGenomes-Gn:BSU28220" /db_xref="EnsemblGenomes-Tr:CAB14782" /db_xref="GOA:P50866" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004487" /db_xref="InterPro:IPR010603" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11387" /db_xref="UniProtKB/Swiss-Prot:P50866" /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTE IVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKV DDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILL KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVAS VPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLE KEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKM LELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVI TGATVTHGEPPRLLLKDGTEVSQDKTSA*" /label="clpX CDS" gene complement(2307141..2308403) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /label="clpX gene" downshifts complement(2307151) /Source="Nicolas_upshifts" /id="D1443" /incds=0 /nref=256 /ntot=333 /MaxReadThrough="2.8818" /MaxDrop="7.82186" /score="40.299167" /energy="-18.9" /TU="U2185" /idTUdmin="U2184" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2308404..2308493) /Source="Nicolas_S_feature" /locus_tag="new_2886044_2886133_c" /HighExp="dia15, dia5, Salt, Diami, C90, H2O2, Paraq, Oxctl, S1, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="1, 0.998, 0.896" /label="S1067" promotor_-10 complement(2308481..2308500) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2308493) /Source="Nicolas_upshifts" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2308495..2308626) /Source="Nicolas_S_feature" /locus_tag="new_2886135_2886266_c" /HighExp="H2O2, dia15, Paraq, Oxctl, G180, G135, HPh, G150, LPh, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1068" promotor_-35 complement(2308512..2308519) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2308671) /Source="Nicolas_upshifts" /id="D1444" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="8.26501" /MaxDrop="4.34985" /score="-0.284489083" /energy="-10.7" /TU="U2185,U2190" /idTUdmin="U2190" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" CDS complement(2308675..2309949) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9748346, 12224648, 16156784, 17021213" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9748346, 12224648, 16156784, 17021213; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl isomerase (trigger factor)" /protein_id="NP_390701.1" /db_xref="EnsemblGenomes-Gn:BSU28230" /db_xref="EnsemblGenomes-Tr:CAB14783" /db_xref="GOA:P80698" /db_xref="InterPro:IPR001179" /db_xref="InterPro:IPR005215" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR008881" /db_xref="InterPro:IPR027304" /db_xref="InterPro:IPR036611" /db_xref="SubtiList:BG19023" /db_xref="UniProtKB/Swiss-Prot:P80698" /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGF RKGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGE SLIFTAKVTVKPEVKLGEYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAV EEGNTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVT FPEEYHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRL EEAKENEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELY TQFSGQDEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNM PVENIKQAIGSTDAMKEDLKVRKAIDFLVENR*" /label="tig CDS" gene complement(2308675..2309949) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /label="tig gene" S_feature complement(2309950..2310139) /Source="Nicolas_S_feature" /locus_tag="new_2887590_2887779_c" /HighExp="H2O2, HPh, BMM, dia15, T-4.40H, G180, Paraq, Oxctl, LBGexp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1069" promotor_-10 complement(2310126..2310145) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2310139) /Source="Nicolas_upshifts" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2310160..2310164) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2310177..2311181) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390702.2" /db_xref="EnsemblGenomes-Gn:BSU28240" /db_xref="EnsemblGenomes-Tr:CAB14784" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12338" /db_xref="UniProtKB/Swiss-Prot:P94569" /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAM KYDDTESDLHLGMAICFLELGELEEAESVCEKMLKEGYGHYFTVLQVYMTILIQLKKY EEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVL ASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHIS KFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPF QPKLLSADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL *" /label="ysoA CDS" gene complement(2310177..2311181) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /label="ysoA gene" promotor_-10 complement(2311206..2311225) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2311224) /Source="Nicolas_upshifts" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2311237..2311244) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" CDS complement(2311300..2311899) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (small subunit)" /protein_id="NP_390703.1" /db_xref="EnsemblGenomes-Gn:BSU28250" /db_xref="EnsemblGenomes-Tr:CAB14785" /db_xref="GOA:P94568" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR004431" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR033940" /db_xref="SubtiList:BG11950" /db_xref="UniProtKB/Swiss-Prot:P94568" /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFF DWRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPS FADIFHQNCFKNGMLPIRMPYDNWKQLVGQYENQSLQMTVDLENQLIHDSEGNQISFE VDPHWKEMLINGYDEISLTLLLEDEIKQFESQRSSWLQA*" /label="leuD CDS" gene complement(2311300..2311899) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /label="leuD gene" downshifts complement(2311321) /Source="Nicolas_upshifts" /id="D1445" /incds=0 /nref=5 /ntot=111 /MaxReadThrough="6.76876" /MaxDrop="3.81278" /score="12.2084487" /energy="-9.9" /TU="U2190,U2191" /idTUdmin="U2186" /TUdmin="-1176" /isTUend="FALSE" /label="downshifts" CDS complement(2311912..2313330) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (large subunit)" /protein_id="NP_390704.1" /db_xref="EnsemblGenomes-Gn:BSU28260" /db_xref="EnsemblGenomes-Tr:CAB14786" /db_xref="GOA:P80858" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR004430" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR033941" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG11949" /db_xref="UniProtKB/Swiss-Prot:P80858" /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEG LRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHS VDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQ QRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMT VCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKS IVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKI EDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLD QIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMA AMAAIHGHFVDVRKFYQEKTVV*" /label="leuC CDS" gene complement(2311912..2313330) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /label="leuC gene" promotor_-35 2313219..2313223 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2313238..2313242 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2313238 /Source="Nicolas_upshifts" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2313380..2314477) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /EC_number="1.1.1.85" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10095787, 15228537, 15916605, 17389690" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10095787, 15228537, 15916605, 17389690; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="NP_390705.2" /db_xref="EnsemblGenomes-Gn:BSU28270" /db_xref="EnsemblGenomes-Tr:CAB14787" /db_xref="GOA:P05645" /db_xref="InterPro:IPR004429" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG10675" /db_xref="UniProtKB/Swiss-Prot:P05645" /translation="MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIG GAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLF ANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVD TLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKL EHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHL FEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTR DLARSEEFSSTQAITEEVKAAIMSENTISNV*" /label="leuB CDS" gene complement(2313380..2314477) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /label="leuB gene" CDS complement(2314498..2316054) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /EC_number="2.3.3.13" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 16330546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="NP_390706.1" /db_xref="EnsemblGenomes-Gn:BSU28280" /db_xref="EnsemblGenomes-Tr:CAB14788" /db_xref="GOA:P94565" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036230" /db_xref="SubtiList:BG11948" /db_xref="UniProtKB/Swiss-Prot:P94565" /translation="MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEA GFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATS DIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDA GASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIE NGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLT GMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRH AFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEF LSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDY RIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMS GLKNHTAVGS*" /label="leuA CDS" gene complement(2314498..2316054) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /label="leuA gene" promotor_-35 2314894..2314897 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2314910..2317351 /Source="Nicolas_S_feature" /locus_tag="new_2892550_2894991" /HighExp="Lbstat, C30, T0.30H, M9-stat, T1.30H, H2O2, M0t90, T2.0H, Salt, BC" /AntisenseName="ilvC" /AntisenseCor="-0.51305153097242795" /AntisenseRegPval="-18.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1070" upshifts 2314910 /Source="Nicolas_upshifts" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2314912..2314931 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2316041..2317069) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /EC_number="1.1.1.86" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 25393291, 25849365; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid isomeroreductase (NADP-dependent)" /protein_id="NP_390707.1" /db_xref="EnsemblGenomes-Gn:BSU28290" /db_xref="EnsemblGenomes-Tr:CAB14789" /db_xref="GOA:P37253" /db_xref="InterPro:IPR000506" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013023" /db_xref="InterPro:IPR013116" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR014359" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10672" /db_xref="UniProtKB/Swiss-Prot:P37253" /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVI VGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKS LVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEA RDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGY QPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKE VLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKE AVVSVAQN*" /label="ilvC CDS" gene complement(2316041..2317069) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /label="ilvC gene" CDS complement(2317093..2317611) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (small subunit)" /protein_id="NP_390708.2" /db_xref="EnsemblGenomes-Gn:BSU28300" /db_xref="EnsemblGenomes-Tr:CAB14790" /db_xref="GOA:P37252" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004789" /db_xref="InterPro:IPR019455" /db_xref="SubtiList:BG10671" /db_xref="UniProtKB/Swiss-Prot:P37252" /translation="MKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVS RITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEI NGIIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQ QKASSNKTISIV*" /label="ilvH CDS" gene complement(2317093..2317611) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /label="ilvH gene" promotor_-35 2317332..2317335 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2317351..2317355 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2317353 /Source="Nicolas_upshifts" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2317608..2319332) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (large subunit)" /protein_id="NP_390709.1" /db_xref="EnsemblGenomes-Gn:BSU28310" /db_xref="EnsemblGenomes-Tr:CAB14791" /db_xref="GOA:P37251" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012846" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10670" /db_xref="UniProtKB/Swiss-Prot:P37251" /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAV LPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADA MIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFH IATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAK KPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYT ANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGD SKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTK GEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVA VVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQP DFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGL HEMVGVKP*" /label="ilvB CDS" gene complement(2317608..2319332) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /label="ilvB gene" S_feature complement(2319333..2319453) /Source="Nicolas_S_feature" /locus_tag="new_2896973_2897093_c" /HighExp="T-5.40H, T-4.40H, S2, MG 120, Glucon, GM-0.2, T-2.40H, GM-0.1, HiOs, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1071" misc_RNA complement(2319454..2319700) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /product="T-box controlling synthesis of branched chain amino acids" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboILV RNA" gene complement(2319454..2319700) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /label="tboILV gene" downshifts complement(2319497) /Source="Nicolas_upshifts" /id="D1446" /incds=0 /nref=18 /ntot=78 /MaxReadThrough="7.67475" /MaxDrop="4.2339" /score="5.33237345" /energy="-13.8" /TU="U2190,U2191" /idTUdmin="U2195" /TUdmin=2682 /isTUend="FALSE" /label="downshifts" S_feature complement(2319701..2319827) /Source="Nicolas_S_feature" /locus_tag="new_2897341_2897467_c" /HighExp="LoTm, HiOs, T-3.40H, BC, B60, Pyr, GM 15, T-5.40H, UNK1, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1072" promotor_-10 complement(2319809..2319828) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-10" upshifts complement(2319827) /Source="Nicolas_upshifts" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="upshifts" S_feature complement(2319829..2319959) /Source="Nicolas_S_feature" /locus_tag="new_2897469_2897599_c" /HighExp="Cold, S8, S0, S7, Mal, S6, G135, M9-stat, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1073" promotor_-35 complement(2319843..2319850) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-35" promotor_-10 complement(2319954..2319973) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2319963) /Source="Nicolas_upshifts" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2319987..2319990) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" promotor_-35 2320085..2320094 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2320108..2320127 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2320110 /Source="Nicolas_upshifts" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="upshifts" CDS 2320148..2320483 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_390710.1" /db_xref="EnsemblGenomes-Gn:BSU28320" /db_xref="EnsemblGenomes-Tr:CAB14792" /db_xref="SubtiList:BG12335" /db_xref="UniProtKB/Swiss-Prot:P94563" /translation="MNKSFADMQGFPAGFPSFPNFPQQYYPAVPPFYQQSQQPFGGYG YGQPFSQAYSPLTTPSGMYSSFPYASGFYGQQFSGAGFSGHGGSLSAPAIHAGGFSGA PGVHGGFRY*" /label="cotQ CDS" gene 2320148..2320483 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /label="cotQ gene" downshifts 2320477 /Source="Nicolas_upshifts" /id="D1447" /incds=0 /nref=14 /ntot=36 /MaxReadThrough="3.79194" /MaxDrop="6.48183" /score="11.836855" /energy="-13" /TU="U2192" /idTUdmin="U2193" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-35 2320564..2320571 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2320585..2320604 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2320587..2320651 /Source="Nicolas_S_feature" /locus_tag="new_2898227_2898291" /HighExp="S5, S6, S8, S7, B36, S4, S3, B60, BT, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.954, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1074" upshifts 2320587 /Source="Nicolas_upshifts" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="upshifts" CDS 2320652..2321107 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17555270, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative indole acetic acid N-acetyltransferase" /protein_id="NP_390711.1" /db_xref="EnsemblGenomes-Gn:BSU28330" /db_xref="EnsemblGenomes-Tr:CAB14793" /db_xref="GOA:P94562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YX0" /db_xref="SubtiList:BG12336" /db_xref="UniProtKB/Swiss-Prot:P94562" /translation="MHIKIDDLTGRQVVSLVNEHLHSMTLMSPPESIHALGLEKLRGP EITFWSAWEGDELAGCGALKELDTRHGEIKSMRTSASHLRKGVAKQVLQHIIEEAEKR GYERLSLETGSMASFEPARKLYESFGFQYCEPFADYGEDPNSVFMTKKL*" /label="ysnE CDS" gene 2320652..2321107 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /label="ysnE gene" promotor_-35 2321215..2321221 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2321235..2321253 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2321242 /Source="Nicolas_upshifts" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="upshifts" CDS 2321291..2322112 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 27464829; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative stress response protein" /protein_id="NP_390712.3" /db_xref="EnsemblGenomes-Gn:BSU28340" /db_xref="EnsemblGenomes-Tr:CAB14794" /db_xref="InterPro:IPR019060" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG12337" /db_xref="UniProtKB/Swiss-Prot:P94560" /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLE SRTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDL DDGKLLVAVDTDADVIAPIDNGNALSGGFSSTNELDYTTKEEKTMPLREEQLKVDKED VQTGEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEE KLEVTKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDPLNNK*" /label="ysnF CDS" gene 2321291..2322112 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /label="ysnF gene" downshifts 2322105 /Source="Nicolas_upshifts" /id="D1448" /incds=0 /nref=8 /ntot=77 /MaxReadThrough="2.49244" /MaxDrop="8.12771" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts 2322169 /Source="Nicolas_upshifts" /id="D1449" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="1.26489" /MaxDrop="4.30778" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin=43 /isTUend="FALSE" /label="downshifts" tRNA complement(2322176..2322249) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg (UCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg2 tRNA" gene complement(2322176..2322249) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /label="trnSL-Arg2 gene" downshifts complement(2322210) /Source="Nicolas_upshifts" /id="D1450" /incds=0 /nref=34 /ntot=243 /MaxReadThrough="1.54905" /MaxDrop="4.72186" /score="24.0242272" /energy="-13.3" /TU="U2195,U2196" /idTUdmin="U2195" /TUdmin="-31" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2322286..2322305) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2322289) /Source="Nicolas_upshifts" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2322319..2322326) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2322380..2322889) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /EC_number="3.1.4.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390713.2" /db_xref="EnsemblGenomes-Gn:BSU28350" /db_xref="EnsemblGenomes-Tr:CAB14795" /db_xref="GOA:P94559" /db_xref="InterPro:IPR000979" /db_xref="InterPro:IPR020935" /db_xref="InterPro:IPR024654" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12334" /db_xref="UniProtKB/Swiss-Prot:P94559" /translation="MNVLIISDSHGLEEELQTIAKRHEAEVDLMIHCGDSELETRHPA LEPYAVVKGNCDFAGDFKDELLLTAGSRKILVTHGHLHGIKQTLLNVYYRAEELGADV ICFGHSHIAGSEVLRGKLMINPGSIRLPRVRRTESYAILTLENDAATVRFYDQAGNEI EDLQNRVTL*" /label="ysnB CDS" gene complement(2322380..2322889) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /label="ysnB gene" downshifts complement(2322397) /Source="Nicolas_upshifts" /id="D1451" /incds=0 /nref=87 /ntot=225 /MaxReadThrough="4.15666" /MaxDrop="5.59323" /score="24.0242272" /energy="-13.3" /TU="U2196,U2197" /idTUdmin="U2197" /TUdmin="-130" /isTUend="FALSE" /label="downshifts" CDS complement(2322905..2323501) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /EC_number="3.6.1.66" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16322510, 17090528, 17976651, 18689515, 19943897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyinosine/deoxyxanthosine triphosphate pyrophosphatase, promiscuous (subunit A)" /protein_id="NP_390714.1" /db_xref="EnsemblGenomes-Gn:BSU28360" /db_xref="EnsemblGenomes-Tr:CAB14796" /db_xref="GOA:P94558" /db_xref="InterPro:IPR002637" /db_xref="InterPro:IPR020922" /db_xref="InterPro:IPR029001" /db_xref="SubtiList:BG12333" /db_xref="UniProtKB/Swiss-Prot:P94558" /translation="MIIMKEAIIATHNPGKVKEFKEILEPRGYDVKSLAEIGFTEEIE ETGHTFEENAIMKAEAVAKAVNKMVIADDSGLSIDNLGGRPGVYSARYAGEQKDDQAN IEKVLSELKGIEKEQRTARFRCALAVSIPGEETKTVEGHVEGYIAEEPRGEYGFGYDP IFIVKDKDKTMAELTSDEKNKISHRADALKKLSKLLEA*" /label="rdgB CDS" gene complement(2322905..2323501) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /label="rdgB gene" CDS complement(2323514..2324251) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /EC_number="2.7.7.56" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1624460, 19153445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624460, 19153445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease PH" /protein_id="NP_390715.1" /db_xref="EnsemblGenomes-Gn:BSU28370" /db_xref="EnsemblGenomes-Tr:CAB14797" /db_xref="GOA:P28619" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR002381" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR018336" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="PDB:1OYP" /db_xref="PDB:1OYR" /db_xref="PDB:1OYS" /db_xref="SubtiList:BG10357" /db_xref="UniProtKB/Swiss-Prot:P28619" /translation="MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVE DRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVV DLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLA AISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGL LGLAEKGIQELIDKQKEVLGDSLPELK*" /label="rph CDS" gene complement(2323514..2324251) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /label="rph gene" promotor_-10 complement(2324333..2324352) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2324349) /Source="Nicolas_upshifts" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2324362..2325462) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14662349, 27381174" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14662349, 27381174; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme" /protein_id="NP_390716.1" /db_xref="EnsemblGenomes-Gn:BSU28380" /db_xref="EnsemblGenomes-Tr:CAB14798" /db_xref="GOA:P39072" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10356" /db_xref="UniProtKB/Swiss-Prot:P39072" /translation="MLKKGPAVIGATCLTSALLLSGCGLFQSDKAAEEIDPPQDVTFV NDEAGANSNTTAAKKTESEKSDTAKADQASSTVMRELYLIDKNGYVVAQTLPLPKSES TAKQALEYLVQGGPVSEILPNGFRAVLPADTTVNVDIKKDGTAIADFSNEFKNYKKED EQKIVQSVTWTLTQFSSIDKVKLRINGHELKEMPVGGTPISDDLSRKDGINLETAGVN DLTATHPLTVYYLAENEDSEYYVPVTKRIDNSEKDDITAAINELAKGPSKVSGLLTDF SEDVKLVSKPKIKDGRVTLDFNQSIFGSADEKTKMISSEVLNSIVLTLTEQPDVKSVS VKVNGKSELVNEKGEKLTEPVSRPSQVNTGSF*" /label="gerM CDS" gene complement(2324362..2325462) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /label="gerM gene" promotor_-35 complement(2324367..2324372) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2324379) /Source="Nicolas_upshifts" /id="D1452" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="5.80816" /MaxDrop="4.3535" /score="41.5916163" /energy="-13" /TU="U2197" /idTUdmin="U2198" /TUdmin=1209 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2325485..2325503) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2325501) /Source="Nicolas_upshifts" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2325518..2325523) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2325577..2326395) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /EC_number="5.1.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15347750, 17610893, 17720142, 19309142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390717.2" /db_xref="EnsemblGenomes-Gn:BSU28390" /db_xref="EnsemblGenomes-Tr:CAB14799" /db_xref="GOA:P94556" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="PDB:1ZUW" /db_xref="SubtiList:BG11964" /db_xref="UniProtKB/Swiss-Prot:P94556" /translation="MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGP RPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGAR AAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDK TADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVST ILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR*" /label="rcmE CDS" gene complement(2325577..2326395) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /label="rcmE gene" downshifts complement(2325589) /Source="Nicolas_upshifts" /id="D1453" /incds=0 /nref=230 /ntot=265 /MaxReadThrough="0.9265" /MaxDrop="6.72492" /score="41.5916163" /energy="-13" /TU="NA" /idTUdmin="U2198" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2326403..2326843) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26577401; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (mother cell's gene expression during sporulation)" /protein_id="NP_390718.1" /db_xref="EnsemblGenomes-Gn:BSU28400" /db_xref="EnsemblGenomes-Tr:CAB14800" /db_xref="GOA:P97247" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12332" /db_xref="UniProtKB/Swiss-Prot:P97247" /translation="MTSKPLEHVADIEKSLRHIAAIIKQKGREILNQYAITPPQFVGL QWLYELGDMTIGELSGKMYLACSTTTDLIDRMQKNELVERVKDPADRRVVRIHLLPEG ERIIQEVITKRQEYLRDMFESFTDEEIAIFEKSLMKLQHEMKRK*" /label="ysmB CDS" gene complement(2326403..2326843) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /label="ysmB gene" promotor_-10 complement(2326886..2326905) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2326895) /Source="Nicolas_upshifts" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2326897..2327039) /Source="Nicolas_S_feature" /locus_tag="new_2904537_2904679_c" /HighExp="BT, B36, S6, S8, S7, B60, Pyr, G/S, Lbtran, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.121047" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1075" promotor_-35 complement(2326921..2326925) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2327084) /Source="Nicolas_upshifts" /id="D1454" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="6.16749" /MaxDrop="4.6532" /score="20.9204638" /energy="-10.8" /TU="U2200,U2202" /idTUdmin="U2202" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" CDS complement(2327087..2327311) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transcriptional regulator required for the expression of late spore coat genes" /protein_id="NP_390719.2" /db_xref="EnsemblGenomes-Gn:BSU28410" /db_xref="EnsemblGenomes-Tr:CAB14801" /db_xref="GOA:P11470" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1FSE" /db_xref="SubtiList:BG10355" /db_xref="UniProtKB/Swiss-Prot:P11470" /translation="MKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVR NHISNAMQKLGVKGRSQAVVELLRMGELEL*" /label="gerE CDS" gene complement(2327087..2327311) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /label="gerE gene" upshifts 2327360 /Source="Nicolas_upshifts" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2327362..2327380 /Source="Nicolas_upshift_promotors" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2327369..2327388) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2327389) /Source="Nicolas_upshifts" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2327402..2327411) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2327427..2327870) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390720.1" /db_xref="EnsemblGenomes-Gn:BSU28420" /db_xref="EnsemblGenomes-Tr:CAB14802" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10354" /db_xref="UniProtKB/Swiss-Prot:P11469" /translation="MKLPAYIDMPFQEWKTSFSFFNKVSVRFSETDMFGHMNNVTPFI YFEEVRISYFKKLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLT LHYLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR*" /label="ysmA CDS" gene complement(2327427..2327870) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /label="ysmA gene" CDS complement(2327931..2328692) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 22720735, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 22720735, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (iron-sulfur protein)" /protein_id="NP_390721.1" /db_xref="EnsemblGenomes-Gn:BSU28430" /db_xref="EnsemblGenomes-Tr:CAB14803" /db_xref="GOA:P08066" /db_xref="InterPro:IPR004489" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR025192" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG10353" /db_xref="UniProtKB/Swiss-Prot:P08066" /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIR RNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKT FPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGV CLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNC VQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV*" /label="sdhB CDS" gene complement(2327931..2328692) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /label="sdhB gene" downshifts complement(2327939) /Source="Nicolas_upshifts" /id="D1455" /incds=0 /nref=61 /ntot=257 /MaxReadThrough="5.46426" /MaxDrop="4.6864" /score="20.9204638" /energy="-10.8" /TU="U2202" /idTUdmin="U2205" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2328695..2330455) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 18535631, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 18535631, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (flavoprotein subunit)" /protein_id="NP_390722.2" /db_xref="EnsemblGenomes-Gn:BSU28440" /db_xref="EnsemblGenomes-Tr:CAB14804" /db_xref="GOA:P08065" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR011280" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10352" /db_xref="UniProtKB/Swiss-Prot:P08065" /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVC AQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVM FNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAAS IVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKY PAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEK FMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSL LSAIYGGMVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYV LHKELGEWMTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQF SNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQD VDVSLITPRKRDYSKKKVAK*" /label="sdhA CDS" gene complement(2328695..2330455) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /label="sdhA gene" CDS complement(2330489..2331097) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /EC_number="1.3.5.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (cytochrome b558 subunit)" /protein_id="NP_390723.1" /db_xref="EnsemblGenomes-Gn:BSU28450" /db_xref="EnsemblGenomes-Tr:CAB14805" /db_xref="GOA:P08064" /db_xref="InterPro:IPR000701" /db_xref="InterPro:IPR011138" /db_xref="InterPro:IPR016002" /db_xref="InterPro:IPR034804" /db_xref="SubtiList:BG10351" /db_xref="UniProtKB/Swiss-Prot:P08064" /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNS AAHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVT GIITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGL WSFAVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV*" /label="sdhC CDS" gene complement(2330489..2331097) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /label="sdhC gene" promotor_-35 2330867..2330874 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2330887..2330906 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2330889 /Source="Nicolas_upshifts" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2331098..2331193) /Source="Nicolas_S_feature" /locus_tag="new_2908738_2908833_c" /HighExp="Lbtran, dia5, Mt0, T0.30H, T1.0H, M0t90, M40t90, T0.0H, Glucon, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.78844099999999995" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1076" promotor_-10 complement(2331183..2331202) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-10" upshifts complement(2331193) /Source="Nicolas_upshifts" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="upshifts" S_feature complement(2331195..2331816) /Source="Nicolas_S_feature" /locus_tag="new_2908835_2909456_c" /HighExp="MG 120, B36, UNK1, Fru, MG 150, BMM, Gly, Glucon, Glu, GM-0.1" /AntisenseName="yslB" /AntisenseCor="-0.44143968421748903" /AntisenseRegPval="-13.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1077" promotor_-35 complement(2331217..2331224) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-35" promotor_-35 2331332..2331336 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2331346..2331446 /Source="Nicolas_upshift_promotors" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2331353..2331372 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2331362 /Source="Nicolas_upshifts" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" CDS 2331390..2331836 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390724.1" /db_xref="EnsemblGenomes-Gn:BSU28460" /db_xref="EnsemblGenomes-Tr:CAB14806" /db_xref="InterPro:IPR019642" /db_xref="InterPro:IPR024096" /db_xref="PDB:3NJC" /db_xref="SubtiList:BG11236" /db_xref="UniProtKB/Swiss-Prot:P42955" /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYW AGKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEP CFQLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV*" /label="yslB CDS" gene 2331390..2331836 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /label="yslB gene" upshifts 2331406 /Source="Nicolas_upshifts" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" downshifts 2331824 /Source="Nicolas_upshifts" /id="D1456" /incds=0 /nref=217 /ntot=255 /MaxReadThrough="2.21897" /MaxDrop="6.5759" /score="4.74486914" /energy="-10.8" /TU="NA" /idTUdmin="U2203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2331862) /Source="Nicolas_upshifts" /id="D1457" /incds=0 /nref=8 /ntot=160 /MaxReadThrough="5.89867" /MaxDrop="4.19639" /score="2.38159916" /energy="-10.8" /TU="U2205" /idTUdmin="U2206" /TUdmin=1270 /isTUend="FALSE" /label="downshifts" CDS complement(2331880..2333106) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2981221, 2981222, 14597663, 1980002, 8757727, 9851048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2981221, 2981222, 14597663, 1980002, 8757727, 9851048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II alpha subunit (aa 1->408)" /protein_id="NP_390725.1" /db_xref="EnsemblGenomes-Gn:BSU28470" /db_xref="EnsemblGenomes-Tr:CAB14807" /db_xref="GOA:P08495" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10350" /db_xref="UniProtKB/Swiss-Prot:P08495" /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMG KSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGI RTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVAL AAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEF AKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTL STIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIET ESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAV ESLHDAFELSKHPSAV*" /label="lysCA CDS" CDS complement(2331880..2332371) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1980002, 2981221, 2981222, 8757727, 9851048, 14597663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1980002, 2981221, 2981222, 8757727, 9851048, 14597663; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II beta subunit (aa 246->408)" /protein_id="YP_009513994.1" /translation="MEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNIN VDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSG MVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHP SAV*" /label="lysCB CDS" gene complement(2331880..2333106) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /label="lysCA gene" gene complement(2331880..2332371) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /label="lysCB gene" downshifts complement(2333220) /Source="Nicolas_upshifts" /id="D1458" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="7.23315" /MaxDrop="4.15833" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=44 /isTUend="FALSE" /label="downshifts" misc_RNA complement(2333232..2333411) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:14523230, 14597663, 14627808, 21169337, 22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523230, 14597663, 14627808, 21169337, 22416067; Product type n: RNA" /label="kswC RNA" gene complement(2333232..2333411) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /label="kswC gene" downshifts complement(2333264) /Source="Nicolas_upshifts" /id="D1459" /incds=0 /nref=22 /ntot=132 /MaxReadThrough="7.09997" /MaxDrop="4.61976" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2333436..2333455) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-10" upshifts complement(2333443) /Source="Nicolas_upshifts" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="upshifts" promotor_-35 complement(2333468..2333475) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-35" CDS complement(2333476..2335248) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /EC_number="4.1.99.3" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8655545, 16267290, 16426634, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655545, 16267290, 16426634, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit C)" /protein_id="NP_390727.2" /db_xref="EnsemblGenomes-Gn:BSU28490" /db_xref="EnsemblGenomes-Tr:CAB14809" /db_xref="GOA:P14951" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR001162" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004791" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR035901" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10349" /db_xref="UniProtKB/Swiss-Prot:P14951" /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSY FTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFI KLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERA KELRDQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSM FPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKK ELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGT NPVSAMIVFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLI IIDGGKGQINAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGDPLEVAYLERNSQEF YLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEA SLEDIKKAGVPAAAAQLLYDKLQK*" /label="uvrC CDS" gene complement(2333476..2335248) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /label="uvrC gene" promotor_-10 complement(2335275..2335294) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-10" upshifts complement(2335289) /Source="Nicolas_upshifts" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="upshifts" promotor_-35 complement(2335308..2335315) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-35" downshifts complement(2335378) /Source="Nicolas_upshifts" /id="D1460" /incds=0 /nref=237 /ntot=268 /MaxReadThrough="4.77689" /MaxDrop="6.41061" /score="23.4086154" /energy="-10.5" /TU="U2207,U2208" /idTUdmin="U2209" /TUdmin=373 /isTUend="FALSE" /label="downshifts" CDS complement(2335384..2335698) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268; Product type c: carrier" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="NP_390728.1" /db_xref="EnsemblGenomes-Gn:BSU28500" /db_xref="EnsemblGenomes-Tr:CAB14810" /db_xref="GOA:P14949" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:2GZY" /db_xref="PDB:2GZZ" /db_xref="PDB:2IPA" /db_xref="PDB:2VOC" /db_xref="SubtiList:BG10348" /db_xref="UniProtKB/Swiss-Prot:P14949" /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQ EMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNK HL*" /label="trxA CDS" gene complement(2335384..2335698) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /label="trxA gene" promotor_-10 complement(2335724..2335743) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2335738) /Source="Nicolas_upshifts" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2335740..2335949) /Source="Nicolas_S_feature" /locus_tag="new_2913380_2913589_c" /HighExp="Etha, Salt, Gly, Sw, M9-stat, LPhT, BC, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984399999999996" /TUshortSig="SigB, SigA" /TUshortPSig="0.991, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1078" promotor_-35 complement(2335759..2335761) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2335843..2335953) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="CDS C-terminal fragment" /db_xref="PSEUDO:SOX90589.1" /translation="MVKYMTVKRRCDLMLRTILMIIGAIVVIGAIIRFVF*" /label="CDS C-terminal fragment" gene complement(2335843..2335953) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /pseudo /label="gene" promotor_-10 complement(2335939..2335957) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-10" upshifts complement(2335949) /Source="Nicolas_upshifts" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="upshifts" promotor_-35 complement(2335972..2335978) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-35" CDS complement(2336021..2337508) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 17827291, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 17827291, 18757805; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exo-alpha-L-arabinofuranosidase" /protein_id="NP_390729.2" /db_xref="EnsemblGenomes-Gn:BSU28510" /db_xref="EnsemblGenomes-Tr:CAB14811" /db_xref="GOA:P94552" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11985" /db_xref="UniProtKB/Swiss-Prot:P94552" /translation="MSEHQAVIQTDIAKGTINKNIYGHFAEHLGRGIYEGIWVGTDSD IPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGGTIESN EFGTHEFMMLCELLECEPYICGNVGSGTVQEMSEWIEYMTFEEGTPMSDWRKQNGREE PWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDDFNW TDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQKH GTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQHC RRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKM NAHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS*" /label="abfB CDS" gene complement(2336021..2337508) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /label="abfB gene" S_feature complement(2337509..2337621) /Source="Nicolas_S_feature" /locus_tag="new_2915149_2915261_c" /HighExp="T0.30H, M40t90, M0t90, BC, M9-stat, T1.30H, T1.0H, T2.0H, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1079" promotor_-10 complement(2337602..2337621) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-10" upshifts complement(2337621) /Source="Nicolas_upshifts" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="upshifts" promotor_-35 complement(2337636..2337643) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-35" CDS complement(2337725..2338702) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 20059546, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 20059546, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (alpha subunit)" /protein_id="NP_390730.1" /db_xref="EnsemblGenomes-Gn:BSU28520" /db_xref="EnsemblGenomes-Tr:CAB14812" /db_xref="GOA:P94551" /db_xref="InterPro:IPR001308" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR014731" /db_xref="InterPro:IPR018206" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR033947" /db_xref="SubtiList:BG11934" /db_xref="UniProtKB/Swiss-Prot:P94551" /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGEN VQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKD LSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNI QASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEG FQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLA GMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS*" /label="etfA CDS" gene complement(2337725..2338702) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /label="etfA gene" downshifts complement(2337733) /Source="Nicolas_upshifts" /id="D1461" /incds=0 /nref=58 /ntot=179 /MaxReadThrough="2.43782" /MaxDrop="7.95053" /score="30.2462458" /energy="-13.5" /TU="NA" /idTUdmin="U2210" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2338738..2339511) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10026281, 17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10026281, 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (beta subunit)" /protein_id="NP_390731.1" /db_xref="EnsemblGenomes-Gn:BSU28530" /db_xref="EnsemblGenomes-Tr:CAB14813" /db_xref="GOA:P94550" /db_xref="InterPro:IPR000049" /db_xref="InterPro:IPR012255" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR033948" /db_xref="SubtiList:BG11935" /db_xref="UniProtKB/Swiss-Prot:P94550" /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEA IQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLY HYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVE GDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKL KTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI*" /label="etfB CDS" gene complement(2338738..2339511) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /label="etfB gene" CDS complement(2339526..2340302) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase" /protein_id="NP_390732.1" /db_xref="EnsemblGenomes-Gn:BSU28540" /db_xref="EnsemblGenomes-Tr:CAB14814" /db_xref="GOA:P94549" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12331" /db_xref="UniProtKB/Swiss-Prot:P94549" /translation="MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDA GVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIH GAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIG SGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVY SYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE*" /label="fadB CDS" gene complement(2339526..2340302) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /label="fadB gene" downshifts 2339591 /Source="Nicolas_upshifts" /id="D1462" /incds=1 /nref=1 /ntot=21 /MaxReadThrough="0.92259" /MaxDrop="4.42725" /score="-8.29305955" /energy="-5.1" /TU="NA" /idTUdmin="U2203" /TUdmin=7767 /isTUend="FALSE" /label="downshifts" CDS complement(2340317..2340901) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17189250, 18941141, 21398533, 24356978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 18941141, 21398533, 24356978; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of fatty acids degradation [FadR-long-chain (C14-C20) acyl-CoAs]" /protein_id="NP_390733.1" /db_xref="EnsemblGenomes-Gn:BSU28550" /db_xref="EnsemblGenomes-Tr:CAB14815" /db_xref="GOA:P94548" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013570" /db_xref="InterPro:IPR036271" /db_xref="PDB:1VI0" /db_xref="PDB:3WHB" /db_xref="PDB:3WHC" /db_xref="SubtiList:BG12330" /db_xref="UniProtKB/Swiss-Prot:P94548" /translation="MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIY LYFKNKEDILISLFKEKMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAI VTQLELRQSNLELRQKINEILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTI DETVTTWVMNDQKYDLVALSNSVLELLVSGIHNK*" /label="fadR CDS" gene complement(2340317..2340901) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /label="fadR gene" promotor_-10 complement(2340943..2340962) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2340943) /Source="Nicolas_upshifts" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2340975..2340982) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2341006..2342688) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17085570, 17189250, 21398533, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17085570, 17189250, 21398533, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long chain acyl-CoA ligase (degradative)" /protein_id="NP_390734.1" /db_xref="EnsemblGenomes-Gn:BSU28560" /db_xref="EnsemblGenomes-Tr:CAB14816" /db_xref="GOA:P94547" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG11946" /db_xref="UniProtKB/Swiss-Prot:P94547" /translation="MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAIS FYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVV QTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPK NILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTT GAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGF EMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAA LPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSE ETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIA DRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKA DTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK*" /label="lcfA CDS" gene complement(2341006..2342688) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /label="lcfA gene" misc_feature complement(2342717..2342736) /Source="Nicolas_upshift_promotors" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2342725) /Source="Nicolas_upshifts" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2342813) /Source="Nicolas_upshifts" /id="D1463" /incds=0 /nref=8 /ntot=101 /MaxReadThrough="2.17789" /MaxDrop="3.3655" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2342877..2343281) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390735.1" /db_xref="EnsemblGenomes-Gn:BSU28570" /db_xref="EnsemblGenomes-Tr:CAB14817" /db_xref="GOA:P94546" /db_xref="InterPro:IPR007140" /db_xref="SubtiList:BG12329" /db_xref="UniProtKB/Swiss-Prot:P94546" /translation="MSDFWENELVEIAAYYSVAVLCLVLFLTVFELVTAYKNWEEIQK GNLAVAMATGGKILGIANVFQHSISQHNSLLQMIGWGVYGFVMLLISYFIFEFLTPRF KIDQEIENDNRAVGFISFVISVGLSFVVAAGI*" /label="yshE CDS" gene complement(2342877..2343281) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /label="yshE gene" downshifts complement(2342879) /Source="Nicolas_upshifts" /id="D1464" /incds=0 /nref=1 /ntot=75 /MaxReadThrough="3.74343" /MaxDrop="2.92029" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2343296..2345653) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11254128, 12719520, 22333191, 27799325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254128, 12719520, 22333191, 27799325; Product type f: factor" /codon_start=1 /transl_table=11 /product="homologous recombination factor" /protein_id="NP_390736.1" /db_xref="EnsemblGenomes-Gn:BSU28580" /db_xref="EnsemblGenomes-Tr:CAB14818" /db_xref="GOA:P94545" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR002625" /db_xref="InterPro:IPR005747" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036063" /db_xref="InterPro:IPR036187" /db_xref="SubtiList:BG12328" /db_xref="UniProtKB/Swiss-Prot:P94545" /translation="MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIK KQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQM KHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQ LRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSS SGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTL DFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVIT GPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTF SSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHY PELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQA KSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKD KMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFE KSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLE FIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVS IIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK*" /label="mutSB CDS" gene complement(2343296..2345653) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /label="mutSB gene" CDS complement(2345674..2347386) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /EC_number="2.7.7.7" /EC_number="3.1.11.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:18776221, 18938175, 28254425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18776221, 18938175, 28254425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase/3'-5' exonuclease X" /protein_id="NP_390737.1" /db_xref="EnsemblGenomes-Gn:BSU28590" /db_xref="EnsemblGenomes-Tr:CAB14819" /db_xref="GOA:P94544" /db_xref="InterPro:IPR002054" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR022311" /db_xref="InterPro:IPR027421" /db_xref="InterPro:IPR029398" /db_xref="InterPro:IPR037160" /db_xref="SubtiList:BG12327" /db_xref="UniProtKB/Swiss-Prot:P94544" /translation="MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSL SEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIA KLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALR IAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKS VIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGER ISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQI KGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKE IDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKR LETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRT EHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFL KRND*" /label="polX CDS" gene complement(2345674..2347386) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /label="polX gene" S_feature complement(2347387..2347459) /Source="Nicolas_S_feature" /locus_tag="new_2925027_2925099_c" /HighExp="Cold, LPhT, LBGstat, H2O2, dia15, G180, G135, Sw, G150, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1080" CDS complement(2347460..2347993) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390738.1" /db_xref="EnsemblGenomes-Gn:BSU28600" /db_xref="EnsemblGenomes-Tr:CAB14820" /db_xref="GOA:P94543" /db_xref="InterPro:IPR003825" /db_xref="SubtiList:BG12326" /db_xref="UniProtKB/Swiss-Prot:P94543" /translation="MLDIIILILLLMGTLLGLKRGFILQFIRLTSFILSIAFAALFYK NVAPHLHWIPAPDFSAGQPALSFFTGNLEAAYYNAIAFIVLFIIAKILLRIIGSFLSI VAGIPVIKQINQMLGAVLGFLEVYLFTFVLLYVASVLPVDALQQMMGQSSLANVIINH TPYLSGLLQELWTQYGA*" /label="yshB CDS" gene complement(2347460..2347993) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /label="yshB gene" CDS complement(2348000..2348257) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /experiment="publication(s) with functional evidences, PMID:15317782, 16796675, 18588879, 20711458, 24097947, 26258635" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317782, 16796675, 18588879, 20711458, 24097947, 26258635; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of cell division" /protein_id="NP_390739.1" /db_xref="EnsemblGenomes-Gn:BSU28610" /db_xref="EnsemblGenomes-Tr:CAB14821" /db_xref="GOA:P94542" /db_xref="InterPro:IPR007838" /db_xref="InterPro:IPR023688" /db_xref="InterPro:IPR036192" /db_xref="SubtiList:BG12325" /db_xref="UniProtKB/Swiss-Prot:P94542" /translation="MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREIN EKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD*" /label="zapA CDS" gene complement(2348000..2348257) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /label="zapA gene" promotor_-10 complement(2348284..2348303) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2348300) /Source="Nicolas_upshifts" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2348315..2348322) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2348340..2348359 /Source="Nicolas_upshift_promotors" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2348347 /Source="Nicolas_upshifts" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="upshifts" CDS 2348391..2349332 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /EC_number="3.1.26.4" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9888800, 10094689, 12794188, 23882084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888800, 10094689, 12794188, 23882084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HIII" /protein_id="NP_390740.1" /db_xref="EnsemblGenomes-Gn:BSU28620" /db_xref="EnsemblGenomes-Tr:CAB14822" /db_xref="GOA:P94541" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR004641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR024568" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12324" /db_xref="UniProtKB/Swiss-Prot:P94541" /translation="MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTIT AYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEV GTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVL KNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLK GRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDE AAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS*" /label="rnhC CDS" gene 2348391..2349332 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /label="rnhC gene" promotor_-10 complement(2349064..2349083) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2349079) /Source="Nicolas_upshifts" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2349097..2349104) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2349315 /Source="Nicolas_upshifts" /id="D1465" /incds=0 /nref=150 /ntot=232 /MaxReadThrough="1.71535" /MaxDrop="5.25365" /score="25.6336933" /energy="-13.7" /TU="NA" /idTUdmin="U2213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2349347) /Source="Nicolas_upshifts" /id="D1466" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.4685" /MaxDrop="5.29665" /score="-4.45611985" /energy="-14.9" /TU="NA" /idTUdmin="U2216" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2349368..2351782) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (beta subunit)" /protein_id="NP_390741.1" /db_xref="EnsemblGenomes-Gn:BSU28630" /db_xref="EnsemblGenomes-Tr:CAB14823" /db_xref="GOA:P17922" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004532" /db_xref="InterPro:IPR005121" /db_xref="InterPro:IPR005146" /db_xref="InterPro:IPR005147" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020825" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR036690" /db_xref="SubtiList:BG10875" /db_xref="UniProtKB/Swiss-Prot:P17922" /translation="MFVSYKWLEDYVDLKGMDPAVLAEKITRAGIEVEGIEYKGEGIK GVVIGHVLEREQHPNADKLNKCLVDIGAEAPVQIICGAPNVDKGQKVAVATVGAVLPG NFKIKKAKLRGEESNGMICSLQELGIESKLVAKEYAEGIFVFPNDAETGSDALAALQL DDAILELGLTPNRADAMNMLGVAYEVAAILDTEVKLPQTDYPAASEQASDYISVKIED QEANPLYTAKIIKNVTIAPSPLWMQTKLMNAGIRPHNNVVDITNFVLLEYGQPLHAFD YDRFGSKEVVVRKAAENEMIVTLDDQERKLSADHLVITNGTKAQAVAGVMGGAESEVQ EDTKTILLEAAYFNGQKVRKASKDLGLRSESSVRFEKGIDPARVRLAAERAAQLIHLY AGGEVLAGTVEEDHLTIEANNIHVSADKVSSVLGLTISKEELISIYKRLGFTVGEADD LLVVTVPSRRGDITIEEDLIEEAARLYGYDNIPSTLPETAGTTGGLTPYQAKRRKVRR FLEGAGLSQAITYSLTNEKKATAFAIEKSLNTVLALPMSEERSILRHSLVPNLLDSVS YNLARQTDSVALYEVGSVFLTKEEDTKPVETERVAGAVTGLWRKQLWQGEKKPVDFFV VKGIVEGLLDKLNVLDSIEFVQSERKQLHPGRTANILLNGSLIGFIGQVHPSLEKELD IKETYVFELDLHALLAAETAPLVYTAIPKYPSVTRDIALVTDKTVTSGQLESVIKEAG GKLLKEVTVFDVYEGEHMEEGKKSVAFSLQYVNPEQTLTEEEVTKAHSKVLKALEDTY QAVLRG*" /label="pheT CDS" gene complement(2349368..2351782) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /label="pheT gene" downshifts complement(2349391) /Source="Nicolas_upshifts" /id="D1467" /incds=0 /nref=214 /ntot=255 /MaxReadThrough="3.98669" /MaxDrop="7.11892" /score="32.4736491" /energy="-14.7" /TU="NA" /idTUdmin="U2216" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2351798..2352832) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390742.1" /db_xref="EnsemblGenomes-Gn:BSU28640" /db_xref="EnsemblGenomes-Tr:CAB14824" /db_xref="GOA:P17921" /db_xref="InterPro:IPR002319" /db_xref="InterPro:IPR004188" /db_xref="InterPro:IPR004529" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR022911" /db_xref="SubtiList:BG10874" /db_xref="UniProtKB/Swiss-Prot:P17921" /translation="MEEKLKQLEQEALEQVEAASSLKVVNDIRVQYLGKKGPITEVLR GMGKLSAEERPKMGALANEVRERIANAIADKNEKLEEEEMKQKLAGQTIDVTLPGNPV AVGGRHPLTVVIEEIEDLFIGMGYTVEEGPEVETDYYNFESLNLPKEHPARDMQDSFY ITEETLMRTQTSPVQTRTMEKHEGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVV DKNISMSDLKGTLELVAKKMFGQDREIRLRPSFFPFTEPSVEVDVTCFKCGGNGCSVC KGTGWIEILGAGMVHPNVLKMAGFDPKEYQGFAFGMGVERIAMLKYGIDDIRHFYTND VRFISQFKQA*" /label="pheS CDS" gene complement(2351798..2352832) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /label="pheS gene" S_feature complement(2352833..2353153) /Source="Nicolas_S_feature" /locus_tag="new_2930473_2930793_c" /HighExp="HPh, Cold, GM 15, GM 10, Sw, C30, G150, MG-0.2, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1081" CDS 2352914..2353120 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513995.1" /translation="MWPRYHPYFRQTDAVVSFIDITESDSGSPLRAVYAVPATTQEVK PISGCVKNALSQRHFLPGKQLIRN*" /label="hypothetical protein CDS" gene 2352914..2353120 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /label="gene" S_feature 2353143..2353407 /Source="Nicolas_S_feature" /locus_tag="new_2930783_2931047" /HighExp="S8, S7, S6, BT, C30, B36, S5, Pyr, C90, Glucon" /AntisenseName="ysgA" /AntisenseCor="-0.23049778674462801" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.519" /TUlongSig="NA" /TUlongPSig="NA" /label="S1082" upshifts 2353143 /Source="Nicolas_upshifts" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2353148..2353167) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2353150..2353164 /Source="Nicolas_upshift_promotors" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2353153) /Source="Nicolas_upshifts" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2353182..2353185) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2353187..2353933) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 24809820, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal RNA methylase" /protein_id="NP_390743.1" /db_xref="EnsemblGenomes-Gn:BSU28650" /db_xref="EnsemblGenomes-Tr:CAB14825" /db_xref="GOA:P94538" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG12323" /db_xref="UniProtKB/Swiss-Prot:P94538" /translation="MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKS PGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLAT ARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPV VRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKT DLNLYVPLYGQAESLNVAVAAAILVYHLRG*" /label="rlmBB CDS" gene complement(2353187..2353933) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /label="rlmBB gene" promotor_-10 complement(2353960..2353979) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-10" promotor_-35 2353966..2353972 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2353973) /Source="Nicolas_upshifts" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="upshifts" promotor_-10 2353986..2353997 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2353993..2353999) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-35" upshifts 2354000 /Source="Nicolas_upshifts" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2354052..2354267 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8171126, 10806362, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8171126, 10806362, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_390744.1" /db_xref="EnsemblGenomes-Gn:BSU28660" /db_xref="EnsemblGenomes-Tr:CAB14826" /db_xref="GOA:P94537" /db_xref="InterPro:IPR017525" /db_xref="SubtiList:BG12318" /db_xref="UniProtKB/Swiss-Prot:P94537" /translation="MDLNLRHAVIANVTGNNQEQLEHTIVDAIQSGEEKMLPGLGVLF EVIWQHASESEKNEMLKTLEGGLKPAE*" /label="sspI CDS" gene 2354052..2354267 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /label="sspI gene" S_feature complement(2354249..2355661) /Source="Nicolas_S_feature" /locus_tag="new_2931889_2933301_c" /HighExp="S6, S8, S7, BT, S5, C30, B36, S4, B60, C90" /AntisenseName="ysfB" /AntisenseCor="0.46970634471519201" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1083" promotor_-35 2354278..2354285 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2354301..2354320 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2354309 /Source="Nicolas_upshifts" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2354336..2355442 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (glycolate degradation operon)" /protein_id="NP_390745.2" /db_xref="EnsemblGenomes-Gn:BSU28670" /db_xref="EnsemblGenomes-Tr:CAB14827" /db_xref="InterPro:IPR008599" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12319" /db_xref="UniProtKB/Swiss-Prot:P94536" /translation="MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQF HEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFG ELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSR RQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRK ILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLD MCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRY RLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK*" /label="ysfB CDS" gene 2354336..2355442 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /label="ysfB gene" promotor_-35 2355478..2355481 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2355497..2355516 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2355501 /Source="Nicolas_upshifts" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="upshifts" CDS 2355545..2356957 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase subunit" /protein_id="NP_390746.1" /db_xref="EnsemblGenomes-Gn:BSU28680" /db_xref="EnsemblGenomes-Tr:CAB14828" /db_xref="GOA:P94535" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR004490" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12320" /db_xref="UniProtKB/Swiss-Prot:P94535" /translation="MITKDVKEQLIQVSGPENFDDSNAGRLVYSYDATPQYQSMPDAV IAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMNQILEIDE ENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT RDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVPKPE TKKTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTLLVIEDYAKIGLPTSAKAV LLIEQDGPFETVERDMEKIEAICKKGDAVSVQTAQTEEEAFALTEARRSALSALARLK PTTILEDATVPRSEIANMVKAINDIAAKYDISICTFGHAGDGNLHPTCTTDIRNKDEM ERVEQAFAEIFEKAIELGGTITGEHGVGEMKAPYLEMKLKKEGIDAMKALKAAFDPRN ILNPGKMFAKDARKRVVAER*" /label="glcD CDS" gene 2355545..2356957 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /label="glcD gene" promotor_-10 complement(2355647..2355666) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2355661) /Source="Nicolas_upshifts" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2355679..2355688) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2356954..2358288 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase (iron-sulfur subunit)" /protein_id="NP_390747.1" /db_xref="EnsemblGenomes-Gn:BSU28690" /db_xref="EnsemblGenomes-Tr:CAB14829" /db_xref="GOA:P94534" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012257" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="SubtiList:BG12321" /db_xref="UniProtKB/Swiss-Prot:P94534" /translation="MTTEKEMKQIQNEFKERMDEGELLNCMRCGFCLPSCPTYIESGF QETHSPRGRIALMKAVADGMIEPDEDVERSLSLCLGCRACEPVCPSGVKYGQLLEEAR DIIHQNKKHSLGERVMRKTAFHELFPHQNRMRSAVSLIGLYQRSGLQTAVRKSGMLRV LPEHLRTMEAVLPDVPKSKDMKHRPRFLPSIGPMKKRVAFFSGCLMDTMFLPTNNATL KLLQLAGCDIVIPPEQACCGALHGHSGEKNTGKELAKQNIAAFEALDVDAVITNAGGC GAFLTEYDHLLKDDPEWSERAAAFVQKLKDFSSVLVELDFHQMDLALETPQVVTYQDS CHLRNVMHTSLEPRQLLKSIKGAEFKEMEKADSCCGSAGIYNIVEVEMSMKILDSKMA AVKATEAILIVTANPGCLLQMKLGIEREGLSGKVRAVHLADLLLEAAGHKTS*" /label="glcF CDS" gene 2356954..2358288 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /label="glcF gene" Polymorphism join(2357987,2357989) /Source="geneious" /ID="SNP_BsDelta6_2935628_2935628" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=1035 /Change="C -> T" /Codon_Change="CTC -> CTT" /Coverage=142 /locus_tag="BSU_28690" /Protein_Effect="None" /Reference_Frequency="1.4%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=140 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2358286 /Source="Nicolas_upshifts" /id="D1468" /incds=0 /nref=48 /ntot=148 /MaxReadThrough="3.07756" /MaxDrop="5.25031" /score="4.55188138" /energy="-14.3" /TU="U2220" /idTUdmin="U2220" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" downshifts complement(2358325) /Source="Nicolas_upshifts" /id="D1469" /incds=0 /nref=27 /ntot=221 /MaxReadThrough="1.51397" /MaxDrop="5.34865" /score="-5.71907967" /energy="-14.3" /TU="NA" /idTUdmin="U2222" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2358327..2358569) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390748.1" /db_xref="EnsemblGenomes-Gn:BSU28700" /db_xref="EnsemblGenomes-Tr:CAB14830" /db_xref="InterPro:IPR025870" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12322" /db_xref="UniProtKB/Swiss-Prot:P94533" /translation="MALNTRESARDITALDIPDTSASNTFEIGFVTENVEAVIKRMRE QGVSIIGEPKVKPWGQTVAYIADPDGHYIEICSPME*" /label="ysfE CDS" gene complement(2358327..2358569) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /label="ysfE gene" S_feature complement(2358570..2358741) /Source="Nicolas_S_feature" /locus_tag="new_2936210_2936381_c" /HighExp="Sw, M0t90, M40t90, M9-stat, T2.0H, BC, T0.30H, Lbstat, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1084" CDS complement(2358629..2358799) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513996.1" /translation="MGADVERSELKDGSIYTGLEGLLKMLRGVGNESINEISYSIRIG QQAGYSFFTGIF*" /label="hypothetical protein CDS" gene complement(2358629..2358799) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /label="gene" CDS complement(2358742..2360538) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 1848300, 17320232, 19682248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 1848300, 17320232, 19682248; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="carbon starvation-induced membrane protein" /protein_id="NP_390749.2" /db_xref="EnsemblGenomes-Gn:BSU28710" /db_xref="EnsemblGenomes-Tr:CAB14831" /db_xref="GOA:P94532" /db_xref="InterPro:IPR003706" /db_xref="InterPro:IPR025299" /db_xref="SubtiList:BG11924" /db_xref="UniProtKB/Swiss-Prot:P94532" /translation="MNAVTIVIASMCILAIAYRLYGTFMMVKVLKVNDDKPTPAHALE DGKDYVPTNKWVSFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDI VVLFASMRKNGKSLSEVAKDELGPVAGFCTGLSMLFIITITMAGLSMVVLHALERNPW GTFAVGITIPIAMGVGLFYKKTGNLKLASTVGFLFLMAGVFIGPWVQTTALGDFLTLD TKTLAIALPVYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIVGVFVVNPSIPFPAF TEFVKGGGPVLAGPVWPFISITIACGAISGFHAFVGSGTTPKMLNKWSDMKPVAFGAM LVECLVGIMALIAATALQPADYFAINSTPEVFRTLGMNVVHLPELSGEIGLDLEGRTG GAVTLAVGMTYIFTGMPFFSHLASYFFQFVIMFEAVFILTAIDAGTRVARYLIQDFFG EVYKPLKKTDWIPGSVFASALACLMWGYLLYSGDIGSIWALFGVSNQLMASVGLIIGA TIVLKIADKRRYILTCLIPLAYLYVTVNYAGYWMVRNVYLNPEAAGYSVLNGVLSIIM LVLGFIIIVAAVKKWAQMWKDPSLRMEASIPG*" /label="cstA CDS" gene complement(2358742..2360538) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /label="cstA gene" promotor_-10 complement(2358844..2358862) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2358862) /Source="Nicolas_upshifts" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2358874..2358882) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2360535 /Source="Nicolas_upshifts" /id="D1470" /incds=0 /nref=4 /ntot=49 /MaxReadThrough="0.92122" /MaxDrop="3.18629" /score="12.2066828" /energy="-15.2" /TU="NA" /idTUdmin="U2220" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2360563..2360582) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2360573) /Source="Nicolas_upshifts" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2360597..2360603) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2360633..2360689) /Source="Nicolas_S_feature" /locus_tag="new_2938273_2938329_c" /HighExp="BC, Sw, M40t90, T1.30H, M0t90, T1.0H, T0.30H, Lbstat, T2.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1085" downshifts complement(2360657) /Source="Nicolas_upshifts" /id="D1471" /incds=0 /nref=12 /ntot=40 /MaxReadThrough="0.655710000000001" /MaxDrop="5.03461" /score="9.68754272" /energy="-10.5" /TU="NA" /idTUdmin="U2224" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2360690..2362192) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12777810, 14973026, 16233670, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12777810, 14973026, 16233670, 18757805; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-L-arabinofuranosidase" /protein_id="NP_390750.2" /db_xref="EnsemblGenomes-Gn:BSU28720" /db_xref="EnsemblGenomes-Tr:CAB14832" /db_xref="GOA:P94531" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11900" /db_xref="UniProtKB/Swiss-Prot:P94531" /translation="MKKARMIVDKEYKIGEVDKRIYGSFIEHMGRAVYEGIYEPDHPE ADEDGFRKDVQSLIKELQVPIIRYPGGNFLSGYNWEDGVGPVENRPRRLDLAWQTTET NEVGTNEFLSWAKKVNTEVNMAVNLGTRGIDAARNLVEYCNHPKGSYWSDLRRSHGYE QPYGIKTWCLGNEMDGPWQIGHKTADEYGRLAAETAKVMKWVDPSIELVACGSSNSGM PTFIDWEAKVLEHTYEHVDYISLHTYYGNRDNNLPNYLARSMDLDHFIKSVAATCDYV KAKTRSKKTINLSLDEWNVWYHSNEADKKVEPWITARPILEDIYNFEDALLVGSLLIT MLQHADRVKIACLAQLVNVIAPIMTEKGGEAWRQPIFYPYMHASVYGRGESLKPLISS PKYDCSDFTDVPYVDAAVVYSEEEETLTIFAVNKAEDQMETEISLRGFESYQIAEHIV LEHQDIKATNQHNRKNVVPHSNGSSSVSENGLTAHFTPLSWNVIRLKKQS*" /label="abfA CDS" gene complement(2360690..2362192) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /label="abfA gene" downshifts complement(2362063) /Source="Nicolas_upshifts" /id="D1472" /incds=1 /nref=7 /ntot=15 /MaxReadThrough="3.81491" /MaxDrop="6.33773" /score="2.73497974" /energy="-14.2" /TU="U2224,U2225" /idTUdmin="U2224" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(2362167..2362267) /Source="Nicolas_upshift_promotors" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2362207) /Source="Nicolas_upshifts" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2362211..2363056) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390751.2" /db_xref="EnsemblGenomes-Gn:BSU28730" /db_xref="EnsemblGenomes-Tr:CAB14833" /db_xref="GOA:P94530" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11912" /db_xref="UniProtKB/Swiss-Prot:P94530" /translation="MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSEL LRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGL AVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVF FFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWP LIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTV GGVKG*" /label="araQ CDS" gene complement(2362211..2363056) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /label="araQ gene" CDS complement(2363057..2363998) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390752.1" /db_xref="EnsemblGenomes-Gn:BSU28740" /db_xref="EnsemblGenomes-Tr:CAB14834" /db_xref="GOA:P94529" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11911" /db_xref="UniProtKB/Swiss-Prot:P94529" /translation="MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFL VFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLI PVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLK LGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTM KKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGL AYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG*" /label="araP CDS" gene complement(2363057..2363998) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /label="araP gene" CDS complement(2364034..2365335) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="sugar-binding lipoprotein" /protein_id="NP_390753.2" /db_xref="EnsemblGenomes-Gn:BSU28750" /db_xref="EnsemblGenomes-Tr:CAB14835" /db_xref="GOA:P94528" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG11910" /db_xref="UniProtKB/Swiss-Prot:P94528" /translation="MKKMTVCFLVLMMLLTLVIAGCSAEKSSGKSGETELTFWTFNGL HEQFYVEMVKEWNKKYPDRKIKLNTVVYPYGQMHDNLSISLIAGEGVPDIADVELARF SNFLKGSDIPLADLTPLIEKDRDKFVEARLTLYSKNGKLYGLDTHVGTTVMFYNMDVM KKAGVNPDDIKTWDDYHKAGQKVRKVTGKPMGTVETNDSATFLSMISQQNSGYFDKNG KLILNNDTNVKTLQYLKDMINDKTMIPAPGGGHHSEEYYGFMNQGGAASVLMPIWYMG RFIDYMPDLKGKIAIRPLPAWKEGGDRSAGLGGTATVVPKQSKHVELAKEFLAFAKGS EEGNKKLWSVLGFDPLRWDVWSSKELKEKNKYTDYFQNGTGIFSVLLDIKDEINPIYL HEDFAKASDLVNRSVLFDALKSQQKTPKQALDRAAGELKQK*" /label="araN CDS" gene complement(2364034..2365335) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /label="araN gene" CDS complement(2365366..2366550) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /EC_number="1.1.1.261" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-1-phosphate dehydrogenase [NAD+] (catabolic)" /protein_id="NP_390754.1" /db_xref="EnsemblGenomes-Gn:BSU28760" /db_xref="EnsemblGenomes-Tr:CAB14836" /db_xref="GOA:P94527" /db_xref="InterPro:IPR023003" /db_xref="InterPro:IPR032837" /db_xref="SubtiList:BG11909" /db_xref="UniProtKB/Swiss-Prot:P94527" /translation="MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRK NNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIH TKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTT IQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAK IVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWI EMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPR GEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGL YE*" /label="egsA CDS" gene complement(2365366..2366550) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /label="egsA gene" CDS complement(2366547..2367365) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /EC_number="3.1.3.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 14973026, 21575135, 22720735, 25848029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 14973026, 21575135, 22720735, 25848029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycolytic and pentose phosphate intermediates phosphatase" /protein_id="NP_390755.1" /db_xref="EnsemblGenomes-Gn:BSU28770" /db_xref="EnsemblGenomes-Tr:CAB14837" /db_xref="GOA:P94526" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11908" /db_xref="UniProtKB/Swiss-Prot:P94526" /translation="MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRM GKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLG EQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDR SFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGD SIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI*" /label="araL CDS" gene complement(2366547..2367365) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /label="araL gene" CDS complement(2367343..2368032) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /EC_number="5.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10417639, 11418559, 11732895, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulose-5-phosphate 4-epimerase" /protein_id="NP_390756.1" /db_xref="EnsemblGenomes-Gn:BSU28780" /db_xref="EnsemblGenomes-Tr:CAB14838" /db_xref="GOA:P94525" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR004661" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG11906" /db_xref="UniProtKB/Swiss-Prot:P94525" /translation="MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPS GVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATS WAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQV PGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYR KHGANAYYGQS*" /label="araD CDS" gene complement(2367343..2368032) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /label="araD gene" CDS complement(2368049..2369731) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /EC_number="2.7.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 173711, 4910050, 10417639, 11418559, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulokinase" /protein_id="NP_390757.1" /db_xref="EnsemblGenomes-Gn:BSU28790" /db_xref="EnsemblGenomes-Tr:CAB14839" /db_xref="GOA:P94524" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005929" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG11905" /db_xref="UniProtKB/Swiss-Prot:P94524" /translation="MAYTIGVDFGTLSGRAVLVHVQTGEELAAAVKEYRHAVIDTVLP KTGQKLPRDWALQHPADYLEVLETTIPSLLEQTGVDPKDIIGIGIDFTACTILPIDSS GQPLCMLPEYEEEPHSYVKLWKHHAAQKHADRLNQIAEEEGEAFLQRYGGKISSEWMI PKVMQIAEEAPHIYEAADRIIEAADWIVYQLCGSLKRSNCTAGYKAMWSEKAGYPSDD FFEKLNPSMKTITKDKLSGSIHSVGEKAGSLTEKMAKLTGLLPGTAVAVANVDAHVSV PAVGITEPGKMLMIMGTSTCHVLLGEEVHIVPGMCGVVDNGILPGYAGYEAGQSCVGD HFDWFVKTCVPPAYQEEAKEKNIGVHELLSEKANHQAPGESGLLALDWWNGNRSTLVD ADLTGMLLGMTLLTKPEEIYRALVEATAYGTRMIIETFKESGVPIEELFAAGGIAEKN PFVMQIYADVTNMDIKISGSPQAPALGSAIFGALAAGKEKGGYDDIKKAAANMGKLKD ITYTPNAENAAVYEKLYAEYKELVHYFGKENHVMKRLKTIKNLQFSSAAKKN*" /label="araB CDS" gene complement(2368049..2369731) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /label="araB gene" CDS complement(2369745..2371235) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /EC_number="5.3.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 10669396, 11418559, 14973026, 18263741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 10669396, 11418559, 14973026, 18263741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-arabinose isomerase" /protein_id="NP_390758.2" /db_xref="EnsemblGenomes-Gn:BSU28800" /db_xref="EnsemblGenomes-Tr:CAB14840" /db_xref="GOA:P94523" /db_xref="InterPro:IPR003762" /db_xref="InterPro:IPR004216" /db_xref="InterPro:IPR009015" /db_xref="InterPro:IPR024664" /db_xref="SubtiList:BG11904" /db_xref="UniProtKB/Swiss-Prot:P94523" /translation="MLQTKDYEFWFVTGSQHLYGEETLELVDQHAKSICEGLSGISSR YKITHKPVVTSPETIRELLREAEYSETCAGIITWMHTFSPAKMWIEGLSSYQKPLMHL HTQYNRDIPWGTIDMDFMNSNQSAHGDREYGYINSRMGLSRKVIAGYWDDEEVKKEMS QWMDTAAALNESRHIKVARFGDNMRHVAVTDGDKVGAHIQFGWQVDGYGIGDLVEVMD RITDDEVDTLYAEYDRLYVISEETKRDEAKVASIKEQAKIELGLTAFLEQGGYTAFTT SFEVLHGMKQLPGLAVQRLMEKGYGFAGEGDWKTAALVRMMKIMAKGKRTSFMEDYTY HFEPGNEMILGSHMLEVCPTVALDQPKIEVHSLSIGGKEDPARLVFNGISGSAIQASI VDIGGRFRLVLNEVNGQEIEKDMPNLPVARVLWKPEPSLKTAAEAWILAGGAHHTCLS YELTAEQMLDWAEMAGIESVLISRDTTIHKLKHELKWNEALYRLQK*" /label="araA CDS" gene complement(2369745..2371235) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /label="araA gene" promotor_-10 complement(2371328..2371347) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2371335) /Source="Nicolas_upshifts" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2371337..2371412) /Source="Nicolas_S_feature" /locus_tag="new_2948977_2949052_c" /HighExp="M9-stat, T1.30H, T2.0H, T2.30H, T3.0H, T4.0H, T3.30H, T1.0H, BC, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1086" promotor_-35 complement(2371362..2371369) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2371413..2372384) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 15556708, 17827291, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 15556708, 17827291, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan-endo-1,5-alpha-L-arabinase" /protein_id="NP_390759.2" /db_xref="EnsemblGenomes-Gn:BSU28810" /db_xref="EnsemblGenomes-Tr:CAB14841" /db_xref="GOA:P94522" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR016840" /db_xref="InterPro:IPR023296" /db_xref="PDB:1UV4" /db_xref="SubtiList:BG11901" /db_xref="UniProtKB/Swiss-Prot:P94522" /translation="MKKKKTWKRFLHFSSAALAAGLIFTSAAPAEAAFWGASNELLHD PTMIKEGSSWYALGTGLTEERGLRVLKSSDAKNWTVQKSIFTTPLSWWSNYVPNYGQN QWAPDIQYYNGKYWLYYSVSSFGSNTSAIGLASSTSISSGGWKDEGLVIRSTSSNNYN AIDPELTFDKDGNPWLAFGSFWSGIKLTKLDKSTMKPTGSLYSIAARPNNGGALEAPT LTYQNGYYYLMVSFDKCCDGVNSTYKIAYGRSKSITGPYLDKSGKSMLEGGGTILDSG NDQWKGPGGQDIVNGNILVRHAYDANDNGIPKLLINDLNWSSGWPSY*" /label="abnA CDS" gene complement(2371413..2372384) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /label="abnA gene" S_feature complement(2372385..2372513) /Source="Nicolas_S_feature" /locus_tag="new_2950025_2950153_c" /HighExp="M9-stat, BC, T2.0H, T2.30H, T3.0H, S8, T1.30H, T3.30H, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1087" promotor_-10 complement(2372498..2372517) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-10" upshifts complement(2372513) /Source="Nicolas_upshifts" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2372532..2372535) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-35" CDS complement(2372581..2373666) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15375159, 16021622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fructose-lysine aminopeptidase" /protein_id="NP_390760.1" /db_xref="EnsemblGenomes-Gn:BSU28820" /db_xref="EnsemblGenomes-Tr:CAB14842" /db_xref="GOA:P94521" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="PDB:1VHE" /db_xref="SubtiList:BG12317" /db_xref="UniProtKB/Swiss-Prot:P94521" /translation="MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTT DRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQR VTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDM IVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGL RGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLR DAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRD DYENAVKLITEVIKKLDRKTVDEITYQ*" /label="frvX CDS" gene complement(2372581..2373666) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /label="frvX gene" downshifts complement(2372595) /Source="Nicolas_upshifts" /id="D1473" /incds=0 /nref=233 /ntot=262 /MaxReadThrough="3.55686" /MaxDrop="6.91328" /score="-0.475558157" /energy="-9.9" /TU="U2227" /idTUdmin="U2227" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2373692..2373711) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-10" upshifts complement(2373715) /Source="Nicolas_upshifts" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2373726..2373733) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-35" promotor_-35 2373784..2373793 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2373799 /Source="Nicolas_upshifts" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2373805..2373820 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2373850..2374242 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10960106, 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390761.1" /db_xref="EnsemblGenomes-Gn:BSU28830" /db_xref="EnsemblGenomes-Tr:CAB14843" /db_xref="GOA:P94520" /db_xref="SubtiList:BG12316" /db_xref="UniProtKB/Swiss-Prot:P94520" /translation="MFVMVLRIILLALFAYCIYAVVKYVANPKRRLKLAQSKEHFYII DEQNNTRKNFQLTYKGVLFEGEKHIPSKDHPLFIHTIFVWTESPEKLKHFSAKDFENI EEKVLERYPNCKIDWDQPIKLAKKAEER*" /label="ysdB CDS" gene 2373850..2374242 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /label="ysdB gene" downshifts 2374213 /Source="Nicolas_upshifts" /id="D1474" /incds=0 /nref=86 /ntot=229 /MaxReadThrough="5.09744" /MaxDrop="4.57118" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-2112" /isTUend="FALSE" /label="downshifts" S_feature 2374258..2374564 /Source="Nicolas_S_feature" /locus_tag="new_2951898_2952204" /HighExp="Etha, M9-stat, T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, S8, T3.30H, Salt" /AntisenseName="ysdA" /AntisenseCor="-0.31305612685159701" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1088" CDS complement(2374258..2374527) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17289755; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_390762.1" /db_xref="EnsemblGenomes-Gn:BSU28840" /db_xref="EnsemblGenomes-Tr:CAB14844" /db_xref="GOA:P94519" /db_xref="InterPro:IPR010718" /db_xref="SubtiList:BG12315" /db_xref="UniProtKB/Swiss-Prot:P94519" /translation="MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVF GALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL*" /label="ysdA CDS" gene complement(2374258..2374527) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /label="ysdA gene" downshifts complement(2374274) /Source="Nicolas_upshifts" /id="D1475" /incds=0 /nref=6 /ntot=206 /MaxReadThrough="2.53274" /MaxDrop="3.80421" /score="20.1281719" /energy="-14" /TU="U2229" /idTUdmin="U2230" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" downshifts complement(2374443) /Source="Nicolas_upshifts" /id="D1476" /incds=1 /nref=1 /ntot=37 /MaxReadThrough="4.90568" /MaxDrop="2.19601" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2374521 /Source="Nicolas_upshifts" /id="D1477" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="4.08794" /MaxDrop="3.37039" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" CDS complement(2374584..2374943) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L20" /protein_id="NP_390763.1" /db_xref="EnsemblGenomes-Gn:BSU28850" /db_xref="EnsemblGenomes-Tr:CAB14845" /db_xref="GOA:P55873" /db_xref="InterPro:IPR005813" /db_xref="InterPro:IPR035566" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11971" /db_xref="UniProtKB/Swiss-Prot:P55873" /translation="MPRVKGGTVTRKRRKKVLKLAKGYFGSKHTLYKVANQQVMKSGN YAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKLSGIEVNRKMLADLAVND LTAFNQLADAAKAQLNK*" /label="rplT CDS" gene complement(2374584..2374943) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /label="rplT gene" downshifts complement(2374597) /Source="Nicolas_upshifts" /id="D1478" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="5.94351" /MaxDrop="6.27682" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(2374975..2375175) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L35" /protein_id="NP_390764.1" /db_xref="EnsemblGenomes-Gn:BSU28860" /db_xref="EnsemblGenomes-Tr:CAB14846" /db_xref="GOA:P55874" /db_xref="InterPro:IPR001706" /db_xref="InterPro:IPR018265" /db_xref="InterPro:IPR021137" /db_xref="InterPro:IPR037229" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11972" /db_xref="UniProtKB/Swiss-Prot:P55874" /translation="MPKMKTHRGSAKRFKKTGSGKLKRSHAYTSHLFANKSQKQKRKL RKSAVVSAGDFKRIKQMLANIK*" /label="rpmI CDS" gene complement(2374975..2375175) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /label="rpmI gene" CDS complement(2375188..2375709) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-3" /protein_id="NP_390765.1" /db_xref="EnsemblGenomes-Gn:BSU28870" /db_xref="EnsemblGenomes-Tr:CAB14847" /db_xref="GOA:P55872" /db_xref="InterPro:IPR001288" /db_xref="InterPro:IPR019813" /db_xref="InterPro:IPR019814" /db_xref="InterPro:IPR019815" /db_xref="InterPro:IPR036787" /db_xref="InterPro:IPR036788" /db_xref="SubtiList:BG11944" /db_xref="UniProtKB/Swiss-Prot:P55872" /translation="MISKDQLVNEGIRAREVRLIGQNGDQLGIKSRQEALEIAGRANL DLVLVAANAKPPVCRIMDYGKFRFEQQKKEKEARKNQKIINLKEVRLSPTIDEHDFNT KLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVATVETKPKMDGR SMFLMLAPKNEKQ*" /label="infC CDS" gene complement(2375188..2375709) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /label="infC gene" misc_RNA complement(2375771..2375910) /locus_tag="BSU_misc_RNA_47" /product="mRNA L20_leader attenuator sequence" /experiment="publication(s) with functional evidences, PMID:17289755, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17289755, 23611891" /label="mRNA L20 leader attenuator sequence" gene complement(2375771..2375910) /locus_tag="BSU_misc_RNA_47" /label="gene" promotor_-10 complement(2375907..2375926) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2375917) /Source="Nicolas_upshifts" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2375919..2375983) /Source="Nicolas_S_feature" /locus_tag="new_2953559_2953623_c" /HighExp="Paraq, G180, G150, G135, H2O2, LPh, C30, Oxctl, LBGexp, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1089" promotor_-35 complement(2375940..2375947) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2375965..2375984) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2375983) /Source="Nicolas_upshifts" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2376000..2376004) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2376102..2376109 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2376123..2376141 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2376123 /Source="Nicolas_upshifts" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="upshifts" CDS 2376155..2376820 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /function="14: Cell envelope" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390767.2" /db_xref="EnsemblGenomes-Gn:BSU28890" /db_xref="EnsemblGenomes-Tr:CAB14849" /db_xref="SubtiList:BG12314" /db_xref="UniProtKB/Swiss-Prot:P94517" /translation="MNKLIQLALFFTLMLTGCSNSSTSSESKVETTVKTTAAFPQKEL EKELKKLKPVSLDMKFESPLATELGKRKAKEEAEKQRQIAAEKKLEKEREAKRKKQQE EKAERQRLAEQQAAERQRLAEAERQAELERQRQAAIQKEQKANAEKKRQSQAQRQQTE APSSNSQDPPSSSSQTDKTIQQPASELPDDDGYGYEERKKWHDDQVEWGIKQGYIDPE DAP*" /label="yscB CDS" gene 2376155..2376820 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /label="yscB gene" downshifts 2376798 /Source="Nicolas_upshifts" /id="D1479" /incds=0 /nref=27 /ntot=178 /MaxReadThrough="2.51181" /MaxDrop="3.43861" /score="13.4996084" /energy="-15.8" /TU="NA" /idTUdmin="U2231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2376852..2377547) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /function="16.5: Explore" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pyruvate import system subunit B" /protein_id="NP_390768.1" /db_xref="EnsemblGenomes-Gn:BSU28900" /db_xref="EnsemblGenomes-Tr:CAB14850" /db_xref="GOA:P94516" /db_xref="InterPro:IPR007300" /db_xref="InterPro:IPR024891" /db_xref="SubtiList:BG12312" /db_xref="UniProtKB/Swiss-Prot:P94516" /translation="MESTMSPYFGIVVSLAAFGIGTFLFKKTKGFFLFTPLFVAMVLG IAFLKIGGFSYADYNNGGEIIKFFLEPATIAFAIPLYKQRDKLKKYWWQIMASIIAGS ICSVTIVYLLAKGIHLDSAVMKSMLPQAATTAIALPLSKGIGGISDITAFAVIFNAVI VYALGALFLKVFKVKNPISKGLALGTSGHALGVAVGIEMGEVEAAMASIAVVVVGVVT VLVIPVFVQLIGG*" /label="pftB CDS" gene complement(2376852..2377547) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /label="pftB gene" downshifts complement(2376874) /Source="Nicolas_upshifts" /id="D1480" /incds=0 /nref=19 /ntot=45 /MaxReadThrough="1.25312" /MaxDrop="6.13174" /score="49.3872074" /energy="-13.7" /TU="NA" /idTUdmin="U2232" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2376918) /Source="Nicolas_upshifts" /id="D1481" /incds=1 /nref=2 /ntot=36 /MaxReadThrough="6.79502" /MaxDrop="3.1016" /score="49.3872074" /energy="-13.7" /TU="U2232" /idTUdmin="U2232" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(2377569..2378009) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15659658, 17452642, 26060272, 27422364, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15659658, 17452642, 26060272, 27422364, 28974613; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyruvate uptake system subunit A" /protein_id="NP_390769.1" /db_xref="EnsemblGenomes-Gn:BSU28910" /db_xref="EnsemblGenomes-Tr:CAB14851" /db_xref="GOA:P94515" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023736" /db_xref="SubtiList:BG12311" /db_xref="UniProtKB/Swiss-Prot:P94515" /translation="MSAKKVYGFLTQAFIFAVIMLVSNMIAAIVPIPIPASVVGLVLL FLLLCLKVIKLEQVETLGTSLTSLIGFLFVPSGISVMNSLGVMQQYGLQIVLVILLAT IILLGATGLFSQLILSLSGKRKTEADMKTKTVQSPQNNNELVHH*" /label="pftA CDS" gene complement(2377569..2378009) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /label="pftA gene" promotor_-10 complement(2378031..2378050) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2378050) /Source="Nicolas_upshifts" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2378066..2378069) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2378143..2378868) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LytS]" /protein_id="NP_390770.1" /db_xref="EnsemblGenomes-Gn:BSU28920" /db_xref="EnsemblGenomes-Tr:CAB14852" /db_xref="GOA:P94514" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11953" /db_xref="UniProtKB/Swiss-Prot:P94514" /translation="MLRVLIVDDEMLARDELAYLLKRTNDEMEINEAENIESAFDQMM DQKPDLLFLDVDLSGENGFDIAKRLKKMKHPPAIVFATAYDQYALKAFEVDALDYLTK PFDEERIQQTLKKYKKVNRDIVETEQNSHAGQHKLALSVGESIVIVDTKDIIYAGTED GHVNVKTFDHSYTVSDTLVVIEKKLPDSDFIRVHRSFVVNTEYIKEIQPWFNSTYNLI MKDGSKIPVSRTYAKELKKLLHI*" /label="lytT CDS" gene complement(2378143..2378868) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /label="lytT gene" downshifts complement(2378172) /Source="Nicolas_upshifts" /id="D1482" /incds=0 /nref=231 /ntot=256 /MaxReadThrough="-0.0173499999999995" /MaxDrop="6.64673" /score="-8.47161605" /energy="-8.9" /TU="NA" /idTUdmin="U2232" /TUdmin="-1298" /isTUend="FALSE" /label="downshifts" CDS complement(2378846..2380627) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /function="16.3: Control" /function="16.13: Shape" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LytT]" /protein_id="NP_390771.1" /db_xref="EnsemblGenomes-Gn:BSU28930" /db_xref="EnsemblGenomes-Tr:CAB14853" /db_xref="GOA:P94513" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11952" /db_xref="UniProtKB/Swiss-Prot:P94513" /translation="MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAIL ISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVG AGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARAL ETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMD HHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTL KMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFL FNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQ ARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDAS VYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEV HKGTEVSFQVPMQQMKEGEEHAQGVNS*" /label="lytS CDS" gene complement(2378846..2380627) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /label="lytS gene" promotor_-35 2380711..2380714 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2380723..2380742) /Source="Nicolas_upshift_promotors" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2380728) /Source="Nicolas_upshifts" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2380729..2380748 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2380736 /Source="Nicolas_upshifts" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2380794..2381576 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:15479782, 24123841, 25848029, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15479782, 24123841, 25848029, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase" /protein_id="NP_390772.2" /db_xref="EnsemblGenomes-Gn:BSU28940" /db_xref="EnsemblGenomes-Tr:CAB14854" /db_xref="GOA:P94512" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12310" /db_xref="UniProtKB/Swiss-Prot:P94512" /translation="MKAVFFDLDDTLLWDEKSVRTTFAETCLQAEKKYGLAPEEFEAA VREAARELYMSYETYPYTVMIGINPFEGLWSNFSEPISEGFQKLNKIVPEYRRNAWTN GLKALGIDDPAYGEYLGEFFAAERRKRPFVYDETFAVLDQLKGKYELLLLTNGDPSLQ KEKLAGVPELAPYFNEIVISGAFGKGKPDVSIFEHCLKLMNIEKDDAIMVGDNLNTDI LGASRAGIKTVWINRTDKKNETDVKPDYIISSLHDLFPILEK*" /label="ysaA CDS" gene 2380794..2381576 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /label="ysaA gene" downshifts 2381560 /Source="Nicolas_upshifts" /id="D1483" /incds=0 /nref=36 /ntot=265 /MaxReadThrough="1.0046" /MaxDrop="6.73727" /score="35.9560361" /energy="-13.8" /TU="NA" /idTUdmin="U2234" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" downshifts complement(2381610) /Source="Nicolas_upshifts" /id="D1484" /incds=0 /nref=89 /ntot=246 /MaxReadThrough="1.13716" /MaxDrop="6.01766" /score="35.534455" /energy="-13.8" /TU="NA" /idTUdmin="U2235" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2381617..2383548) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8692931, 9826762, 10632708, 15831787, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8692931, 9826762, 10632708, 15831787, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_390773.1" /db_xref="EnsemblGenomes-Gn:BSU28950" /db_xref="EnsemblGenomes-Tr:CAB14855" /db_xref="GOA:P18255" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10362" /db_xref="UniProtKB/Swiss-Prot:P18255" /translation="MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLN GKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIE NGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKL ELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQ RVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATI RRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLR PMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFV RPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLK EAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGE DGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKK VQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQN SETISLDEFVKKAVAEAKK*" /label="thrS CDS" gene complement(2381617..2383548) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /label="thrS gene" misc_RNA complement(2383592..2383839) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:9098041, 9826762, 1317842, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 9826762, 1317842, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboT RNA" gene complement(2383592..2383839) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /label="tboT gene" promotor_-10 complement(2383595..2383604) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2383595) /Source="Nicolas_upshifts" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2383650) /Source="Nicolas_upshifts" /id="D1485" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="6.71261" /MaxDrop="3.31801" /score="19.160794" /energy="-16.2" /TU="U2236,U2237,U2238,U2241" /idTUdmin="U2239" /TUdmin=221 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2383850..2383869) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2383863) /Source="Nicolas_upshifts" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2383865..2383945) /Source="Nicolas_S_feature" /locus_tag="new_2961505_2961585_c" /HighExp="S3, S4, LoTm, S5, G135, G180, LBGtran, T5.0H, G/S, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1090" promotor_-35 complement(2383885..2383889) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2383946..2384791) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22882546; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation protein" /protein_id="NP_390774.2" /db_xref="EnsemblGenomes-Gn:BSU28960" /db_xref="EnsemblGenomes-Tr:CAB14856" /db_xref="InterPro:IPR014199" /db_xref="SubtiList:BG10361" /db_xref="UniProtKB/Swiss-Prot:P06569" /translation="MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANP AFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADD LPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKM EQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDH PMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPV KHSEG*" /label="ytxC CDS" gene complement(2383946..2384791) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /label="ytxC gene" promotor_-10 complement(2384811..2384829) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2384817) /Source="Nicolas_upshifts" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2384845..2384850) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2384870..2385511) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25728272, 27190159; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative osomosensing transporter" /protein_id="NP_390775.1" /db_xref="EnsemblGenomes-Gn:BSU28970" /db_xref="EnsemblGenomes-Tr:CAB14857" /db_xref="GOA:P06568" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG10360" /db_xref="UniProtKB/Swiss-Prot:P06568" /translation="MKRKTAVKWLAVLAGAGLLYWGNKTYLNVSPKEIRVWVLSFGVF APLMFIGISIVRPLVLFPVSVISIAGGLAFGPLLGTLYTLFGSMCASAVSFFAAGLFS AKKNGHYERLEAIQKQMEDNGFFYIFLLRILPINFDFVSYAAGLSNVKALPYFAATAV GIIPGTIALNVLGASFLAGNLPAFFMVLALYIVFISLPFIFRKKMQNLFQESN*" /label="ytxB CDS" gene complement(2384870..2385511) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /label="ytxB gene" CDS complement(2385545..2386480) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 17003052, 17289076, 19255093, 19968790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17003052, 17289076, 19255093, 19968790; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="NP_390776.1" /db_xref="EnsemblGenomes-Gn:BSU28980" /db_xref="EnsemblGenomes-Tr:CAB14858" /db_xref="GOA:P06567" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009928" /db_xref="InterPro:IPR027417" /db_xref="PDB:2K7R" /db_xref="PDB:4M4W" /db_xref="SubtiList:BG10359" /db_xref="UniProtKB/Swiss-Prot:P06567" /translation="MEPIGRSLQGVTGRPDFQKRLEQMKEKVMKDQDVQAFLKENEEV IDQKMIEKSLNKLYEYIEQSKNCSYCSEDENCNNLLEGYHPKLVVNGRSIDIEYYECP VKRKLDQQKKQQSLMKSMYIQQDLLGATFQQVDISDPSRLAMFQHVTDFLKSYNETGK GKGLYLYGKFGVGKTFMLAAIANELAEKEYSSMIVYVPEFVRELKNSLQDQTLEEKLN MVKTTPVLMLDDIGAESMTSWVRDEVIGTVLQHRMSQQLPTFFSSNFSPDELKHHFTY SQRGEKEEVKAARLMERILYLAAPIRLDGENRRHP*" /label="dnaI CDS" gene complement(2385545..2386480) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /label="dnaI gene" CDS complement(2386508..2387926) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loading protein; replication initiationmembrane attachment protein" /protein_id="NP_390777.1" /db_xref="EnsemblGenomes-Gn:BSU28990" /db_xref="EnsemblGenomes-Tr:CAB14859" /db_xref="GOA:P07908" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="SubtiList:BG10358" /db_xref="UniProtKB/Swiss-Prot:P07908" /translation="MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFS LYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQ ERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRP FNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSE TMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQ IERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPS KADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVRE AMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQ DLEEQKKKMMEEMQKLKKYSAY*" /label="dnaB CDS" gene complement(2386508..2387926) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /label="dnaB gene" promotor_-10 complement(2387955..2387974) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2387963) /Source="Nicolas_upshifts" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2387989..2387992) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2388041..2388499) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16950922, 27920297, 28624879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950922, 27920297, 28624879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of transcription of ribonucleotide reductase nrd genes and operons" /protein_id="NP_390778.1" /db_xref="EnsemblGenomes-Gn:BSU29000" /db_xref="EnsemblGenomes-Tr:CAB14860" /db_xref="GOA:Q45549" /db_xref="InterPro:IPR003796" /db_xref="InterPro:IPR005144" /db_xref="SubtiList:BG13833" /db_xref="UniProtKB/Swiss-Prot:Q45549" /translation="MKCPSCQHNGTRVLDSRPVDDGKSIRRRRECESCHYRFTTFEKV EETPLIVVKKEGVREEFSREKMLRGLIKACEKRPVSLKTLEDMCFDIEKELRNQGCSE VKSELVGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER*" /label="nrdR CDS" gene complement(2388041..2388499) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /label="nrdR gene" downshifts complement(2388060) /Source="Nicolas_upshifts" /id="D1486" /incds=0 /nref=14 /ntot=175 /MaxReadThrough="4.1553" /MaxDrop="3.90408" /score="12.4797073" /energy="-21.2" /TU="U2239,U2241" /idTUdmin="U2243" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2388500..2388647) /Source="Nicolas_S_feature" /locus_tag="new_2966140_2966287_c" /HighExp="dia5, dia15, Lbstat, Diami, Heat, M9-stat, M0t90, M40t90, LBGtran, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, SigA" /TUshortPSig="0.998, 0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1091" promotor_-10 complement(2388638..2388657) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-10" upshifts complement(2388647) /Source="Nicolas_upshifts" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="upshifts" S_feature complement(2388649..2388727) /Source="Nicolas_S_feature" /locus_tag="new_2966289_2966367_c" /HighExp="Lbstat, M40t90, Heat, M9-stat, M0t90, G180, S8, S5, T1.30H, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1092" promotor_-35 complement(2388672..2388675) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-35" downshifts complement(2388772) /Source="Nicolas_upshifts" /id="D1487" /incds=0 /nref=204 /ntot=262 /MaxReadThrough="5.70146" /MaxDrop="5.85416" /score="12.4797073" /energy="-21.2" /TU="U2241,U2242,U2243" /idTUdmin="U2242" /TUdmin="-237" /isTUend="FALSE" /label="downshifts" CDS complement(2388773..2389153) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /EC_number="4.1.1.50" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 10844697, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10844697, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine decarboxylase" /protein_id="NP_390779.2" /db_xref="EnsemblGenomes-Gn:BSU29010" /db_xref="EnsemblGenomes-Tr:CAB14861" /db_xref="GOA:O34426" /db_xref="InterPro:IPR003826" /db_xref="InterPro:IPR016067" /db_xref="InterPro:IPR017716" /db_xref="SubtiList:BG13832" /db_xref="UniProtKB/Swiss-Prot:O34426" /translation="METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREV AFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIAEALHAD TRENIEIPRGMGPVQIKQAQAKVL*" /label="speD CDS" gene complement(2388773..2389153) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /label="speD gene" S_feature complement(2389154..2389308) /Source="Nicolas_S_feature" /locus_tag="new_2966794_2966948_c" /HighExp="Lbstat, M40t90, M9-stat, T2.0H, T3.0H, M0t90, T3.30H, Sw, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1093" promotor_-10 complement(2389288..2389307) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2389295 /Source="Nicolas_upshifts" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2389296..2389315 /Source="Nicolas_upshift_promotors" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2389308) /Source="Nicolas_upshifts" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2389322..2389328) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2389386..2389397) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2389392..2390414) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /EC_number="1.2.1.59" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NADP-dependent, gluconeogenesis)" /protein_id="NP_390780.1" /db_xref="EnsemblGenomes-Gn:BSU29020" /db_xref="EnsemblGenomes-Tr:CAB14862" /db_xref="GOA:O34425" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12592" /db_xref="UniProtKB/Swiss-Prot:O34425" /translation="MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHL IKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNA KDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPV VKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSL VLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYS DEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARM KHPSAV*" /label="gapB CDS" gene complement(2389392..2390414) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /label="gapB gene" upshifts complement(2389393) /Source="Nicolas_upshifts" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2389412..2389418) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2390458..2390477) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2390489) /Source="Nicolas_upshifts" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2390490..2390497) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2390620..2391000) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HxlR family)" /protein_id="NP_390781.1" /db_xref="EnsemblGenomes-Gn:BSU29030" /db_xref="EnsemblGenomes-Tr:CAB14863" /db_xref="GOA:O34533" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HZT" /db_xref="SubtiList:BG13831" /db_xref="UniProtKB/Swiss-Prot:O34533" /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMP NITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHI NRVYGDTFSVLEESVLNDKLKQES*" /label="ytcD CDS" gene complement(2390620..2391000) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /label="ytcD gene" downshifts complement(2390644) /Source="Nicolas_upshifts" /id="D1488" /incds=0 /nref=17 /ntot=164 /MaxReadThrough="1.55675" /MaxDrop="3.64816" /score="18.9828659" /energy="-15.3" /TU="NA" /idTUdmin="U2245" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(2391001..2391131) /Source="Nicolas_S_feature" /locus_tag="new_2968641_2968771_c" /HighExp="dia15, Diami, dia5, LBGstat, G180, Etha, S5, LBGtran, H2O2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1094" promotor_-35 2391056..2391060 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2391076..2391095 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2391077..2391183 /Source="Nicolas_S_feature" /locus_tag="new_2968717_2968823" /HighExp="Diami, G180, G135, LBGstat, G150, LBGexp, Paraq, Oxctl, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1095" upshifts 2391077 /Source="Nicolas_upshifts" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2391121..2391140) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2391131) /Source="Nicolas_upshifts" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2391155..2391162) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2391184..2392374 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390782.1" /db_xref="EnsemblGenomes-Gn:BSU29040" /db_xref="EnsemblGenomes-Tr:CAB14864" /db_xref="GOA:O34367" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13825" /db_xref="UniProtKB/Swiss-Prot:O34367" /translation="MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPV TTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILL AARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQ FGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITAL GYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALF YMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVD VASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRD RQEA*" /label="ytbD CDS" gene 2391184..2392374 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /label="ytbD gene" promotor_-10 complement(2392006..2392024) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2392022) /Source="Nicolas_upshifts" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2392040..2392045) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2392398..2393240 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /EC_number="1.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19585557, 20981419, 28032445, 28130301" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19585557, 20981419, 28032445, 28130301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aldo/keto reductase" /protein_id="NP_390783.1" /db_xref="EnsemblGenomes-Gn:BSU29050" /db_xref="EnsemblGenomes-Tr:CAB14865" /db_xref="GOA:O34678" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3B3D" /db_xref="SubtiList:BG13826" /db_xref="UniProtKB/Swiss-Prot:O34678" /translation="MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHG YRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSL SKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSV AQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPD NFDF*" /label="ytbE CDS" gene 2392398..2393240 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /label="ytbE gene" promotor_-35 2393013..2393018 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2393034..2393052 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2393035 /Source="Nicolas_upshifts" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2393233 /Source="Nicolas_upshifts" /id="D1489" /incds=0 /nref=13 /ntot=124 /MaxReadThrough="1.16017" /MaxDrop="5.72508" /score="24.0721062" /energy="-11.4" /TU="NA" /idTUdmin="U2244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2393273) /Source="Nicolas_upshifts" /id="D1490" /incds=0 /nref=168 /ntot=263 /MaxReadThrough="3.38494" /MaxDrop="6.57333" /score="13.4291259" /energy="-11.4" /TU="NA" /idTUdmin="U2248" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2393282..2393875) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /EC_number="2.7.1.24" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 11886213, 12538896, 12682299, 15044829, 15526298, 17603993; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphocoenzyme A kinase" /protein_id="NP_390784.1" /db_xref="EnsemblGenomes-Gn:BSU29060" /db_xref="EnsemblGenomes-Tr:CAB14866" /db_xref="GOA:O34932" /db_xref="InterPro:IPR001977" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13824" /db_xref="UniProtKB/Swiss-Prot:O34932" /translation="MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGM PAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDE AVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIR SQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA*" /label="coaE CDS" gene complement(2393282..2393875) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /label="coaE gene" CDS complement(2393891..2394523) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23396918; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane calmodulin-like protein essential for stage III sporulation" /protein_id="NP_390785.2" /db_xref="EnsemblGenomes-Gn:BSU29070" /db_xref="EnsemblGenomes-Tr:CAB14867" /db_xref="GOA:C0SP79" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR014205" /db_xref="SubtiList:BG13823" /db_xref="UniProtKB/Swiss-Prot:C0SP79" /translation="MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSG AVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLL NLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSP IVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL*" /label="spcF CDS" gene complement(2393891..2394523) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /label="spcF gene" S_feature complement(2394524..2394688) /Source="Nicolas_S_feature" /locus_tag="new_2972164_2972328_c" /HighExp="LPhT, dia15, Sw, LBGtran, LBGstat, H2O2, Diami, G135, Lbstat, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1096" CDS complement(2394689..2395519) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /EC_number="3.2.2.23" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15109717, 25825434, 28517932; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formamidopyrimidine-DNA glycosylase; 5-hydroxymethyl-uracil DNA-glycosylase" /protein_id="NP_390786.2" /db_xref="EnsemblGenomes-Gn:BSU29080" /db_xref="EnsemblGenomes-Tr:CAB14868" /db_xref="GOA:O34403" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR012319" /db_xref="InterPro:IPR015886" /db_xref="InterPro:IPR015887" /db_xref="InterPro:IPR020629" /db_xref="InterPro:IPR035937" /db_xref="SubtiList:BG12628" /db_xref="UniProtKB/Swiss-Prot:O34403" /translation="MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFA RKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTD GTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVK TALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAG GSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK *" /label="mutM CDS" gene complement(2394689..2395519) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /label="mutM gene" CDS complement(2395542..2398184) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /EC_number="2.7.7.7" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3125407, 6777244, 9231429, 12081953, 17905985, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3125407, 6777244, 9231429, 12081953, 17905985, 27399782; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase I" /protein_id="NP_390787.1" /db_xref="EnsemblGenomes-Gn:BSU29090" /db_xref="EnsemblGenomes-Tr:CAB14869" /db_xref="GOA:O34996" /db_xref="InterPro:IPR001098" /db_xref="InterPro:IPR002298" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR002562" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR018320" /db_xref="InterPro:IPR019760" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12656" /db_xref="UniProtKB/Swiss-Prot:O34996" /translation="MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMIL MKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQI SRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVE FYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLE SIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFK DLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEE PILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELK GAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEH LGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMG EELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLE KLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTD PNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTND MDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFI DRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNT PIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVM EHALALDVPLKVDFASGPSWYDAK*" /label="polA CDS" gene complement(2395542..2398184) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /label="polA gene" promotor_-10 complement(2398239..2398258) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2398248) /Source="Nicolas_upshifts" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2398272..2398279) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2398308..2398427) /Source="Nicolas_S_feature" /locus_tag="new_2975948_2976067_c" /HighExp="M0t90, M40t90, M9-stat, Lbstat, Sw, T1.30H, T1.0H, S4, S3, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1097" downshifts complement(2398351) /Source="Nicolas_upshifts" /id="D1491" /incds=0 /nref=48 /ntot=175 /MaxReadThrough="5.58383" /MaxDrop="3.85702" /score="15.0073484" /energy="-12.2" /TU="U2249" /idTUdmin="U2254" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2398428..2400167) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_390788.1" /db_xref="EnsemblGenomes-Gn:BSU29100" /db_xref="EnsemblGenomes-Tr:CAB14870" /db_xref="GOA:P23545" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR031967" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3CWF" /db_xref="SubtiList:BG10364" /db_xref="UniProtKB/Swiss-Prot:P23545" /translation="MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIE KEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKV QALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSL AIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLR RLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGI VLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLS IILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISL HLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSG IGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTV FTVTLKRAAEKSA*" /label="phoR CDS" gene complement(2398428..2400167) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /label="phoR gene" CDS complement(2400160..2400882) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_390789.2" /db_xref="EnsemblGenomes-Gn:BSU29110" /db_xref="EnsemblGenomes-Tr:CAB14871" /db_xref="GOA:P13792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1MVO" /db_xref="SubtiList:BG10363" /db_xref="UniProtKB/Swiss-Prot:P13792" /translation="MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAET EKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMT KPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTK KPIYIKTIRGLGYKLEEPKMNE*" /label="phoP CDS" gene complement(2400160..2400882) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /label="phoP gene" promotor_-10 complement(2400950..2400969) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2400960) /Source="Nicolas_upshifts" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2400962..2401062) /Source="Nicolas_S_feature" /locus_tag="new_2978602_2978702_c" /HighExp="M40t90, T1.30H, T1.0H, M0t90, M9-stat, T2.0H, T2.30H, T3.0H, T0.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1098" promotor_-35 complement(2400983..2400989) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2401094..2402032) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /EC_number="1.1.1.37" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate dehydrogenase (NAD-dependent)" /protein_id="NP_390790.1" /db_xref="EnsemblGenomes-Gn:BSU29120" /db_xref="EnsemblGenomes-Tr:CAB14872" /db_xref="GOA:P49814" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011275" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11386" /db_xref="UniProtKB/Swiss-Prot:P49814" /translation="MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPT KGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEK IMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTF VAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGG GEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIV GGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS*" /label="mdh CDS" gene complement(2401094..2402032) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /label="mdh gene" downshifts complement(2401107) /Source="Nicolas_upshifts" /id="D1492" /incds=0 /nref=200 /ntot=242 /MaxReadThrough="8.27126" /MaxDrop="7.40884" /score="-0.758981483" /energy="-13.5" /TU="U2251,U2254" /idTUdmin="U2250" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2402076..2403347) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /EC_number="1.1.1.42" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8045898, 9244258, 11290745, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045898, 9244258, 11290745, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase" /protein_id="NP_390791.1" /db_xref="EnsemblGenomes-Gn:BSU29130" /db_xref="EnsemblGenomes-Tr:CAB14873" /db_xref="GOA:P39126" /db_xref="InterPro:IPR004439" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="PDB:1HQS" /db_xref="SubtiList:BG10856" /db_xref="UniProtKB/Swiss-Prot:P39126" /translation="MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEA AVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGI RSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS EEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTL VHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAA GKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINY ETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIAS KVVTYDFARLMDGATEVKCSEFGEELIKNMD*" /label="icd CDS" gene complement(2402076..2403347) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /label="icd gene" misc_feature complement(2403132..2403151) /Source="Nicolas_upshift_promotors" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2403144) /Source="Nicolas_upshifts" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2403348..2403430) /Source="Nicolas_S_feature" /locus_tag="new_2980988_2981070_c" /HighExp="T2.30H, M40t90, T1.0H, T-3.40H, HiOs, T3.30H, T3.0H, T0.0H, Lbstat, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1099" upshifts complement(2403430) /Source="Nicolas_upshifts" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="upshifts" S_feature complement(2403432..2403510) /Source="Nicolas_S_feature" /locus_tag="new_2981072_2981150_c" /HighExp="T2.30H, T3.30H, T1.0H, M40t90, T3.0H, Lbstat, M0t90, T0.0H, HiOs, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1100" promotor_-10 complement(2403432..2403451) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-10" promotor_-35 complement(2403467..2403471) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-35" CDS complement(2403511..2404629) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase II" /protein_id="NP_390792.1" /db_xref="EnsemblGenomes-Gn:BSU29140" /db_xref="EnsemblGenomes-Tr:CAB14874" /db_xref="GOA:P39120" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR011278" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG10855" /db_xref="UniProtKB/Swiss-Prot:P39120" /translation="MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEI IYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLG LLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTL NGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLH GGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKR LTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRM SGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA*" /label="citZ CDS" gene complement(2403511..2404629) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /label="citZ gene" downshifts 2404124 /Source="Nicolas_upshifts" /id="D1493" /incds=1 /nref=2 /ntot=63 /MaxReadThrough="1.41638" /MaxDrop="3.70762" /score="40.6931963" /energy="-9.9" /TU="NA" /idTUdmin="U2252" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" misc_feature 2404471..2404474 /Source="Nicolas_upshift_promotors" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2404479 /Source="Nicolas_upshifts" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2404608 /Source="Nicolas_upshifts" /id="D1494" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="2.98678" /MaxDrop="3.07929" /score="40.6931963" /energy="-9.9" /TU="U2252" /idTUdmin="U2252" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2404630..2404836) /Source="Nicolas_S_feature" /locus_tag="new_2982270_2982476_c" /HighExp="T3.0H, T3.30H, T2.30H, T4.0H, M0t90, T2.0H, T1.30H, T5.0H, BC, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1101" misc_feature 2404804..2404816 /Source="Nicolas_upshift_promotors" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2404815 /Source="Nicolas_upshifts" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2404822..2404841) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2404836) /Source="Nicolas_upshifts" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2404856..2404860) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2404956) /Source="Nicolas_upshifts" /id="D1495" /incds=0 /nref=116 /ntot=204 /MaxReadThrough="6.4946" /MaxDrop="5.00031" /score="29.3344463" /energy="-8.1" /TU="NA" /idTUdmin="U2255" /TUdmin=14 /isTUend="TRUE" /label="downshifts" CDS complement(2404963..2405427) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390793.1" /db_xref="EnsemblGenomes-Gn:BSU29150" /db_xref="EnsemblGenomes-Tr:CAB14875" /db_xref="GOA:O34811" /db_xref="InterPro:IPR007382" /db_xref="SubtiList:BG13933" /db_xref="UniProtKB/Swiss-Prot:O34811" /translation="MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLF PTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKN GLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS*" /label="ytwI CDS" gene complement(2404963..2405427) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /label="ytwI gene" promotor_-10 complement(2405440..2405459) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2405454) /Source="Nicolas_upshifts" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2405456..2406641) /Source="Nicolas_S_feature" /locus_tag="new_2983096_2984281_c" /HighExp="G135, G180, LBGstat, G150, LBGtran, S0, Paraq, Oxctl, H2O2, LBGexp" /AntisenseName="ytvI" /AntisenseCor="-0.73323145377324295" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1102" promotor_-35 2405456..2405461 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2405472..2405480) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2405476..2405494 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2405482 /Source="Nicolas_upshifts" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="upshifts" CDS 2405524..2406639 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12662922, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sporulation-related permease" /protein_id="NP_390794.1" /db_xref="EnsemblGenomes-Gn:BSU29160" /db_xref="EnsemblGenomes-Tr:CAB14876" /db_xref="GOA:O34991" /db_xref="InterPro:IPR002549" /db_xref="InterPro:IPR014227" /db_xref="SubtiList:BG13930" /db_xref="UniProtKB/Swiss-Prot:O34991" /translation="MNQSYITIFFRTLFVISMTAGSIAAAYYSFPLTYPFLIALILSS VIHPVVDYLDKVTGFPRTINVLGVLAFFLLAAFGVLTILVAEIVTGTAYLAKTLPPHI STFISYCEKLFTTHIQPLYNELTLLFQELETNQQASIVTHIQTLGDSAAKNAGLLLSH ILEMIPRFFALLPNTAAVLIFSLLATFFMTKDWHKLKAMLVLILPDRVTANSKAISSE LKKAMTGFIKAQAVLVFITMVIVFIGLSLLKVEHAATIAFLIGLVDLLPYLGAGSVFV PWILYLSITGQLPQAIGIGILYLVVLIQRQLTEPKILSKSIGIDPLATLIALFAGFKL FGFLGLIAGPAVLVIIQAFITTGALKEIWSYITVQQK*" /label="ytvI CDS" gene 2405524..2406639 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /label="ytvI gene" downshifts 2406610 /Source="Nicolas_upshifts" /id="D1496" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.639" /MaxDrop="3.31897" /score="37.6858539" /energy="-16.7" /TU="NA" /idTUdmin="U2256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2406672..2407055) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15302217, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390795.1" /db_xref="EnsemblGenomes-Gn:BSU29170" /db_xref="EnsemblGenomes-Tr:CAB14877" /db_xref="GOA:O32064" /db_xref="InterPro:IPR007313" /db_xref="SubtiList:BG13935" /db_xref="UniProtKB/Swiss-Prot:O32064" /translation="MRFLFLLFIVFPAIEIGIFLFLGNLIGILPTVLFMILTGIIGAA AAKKQGTEVYYKVQRDLQYGKMPGEAIADGLCIFIGGLLLMLPGFLSDLAGACLLIPF TRGWCKPILFKWLRGMSKNKRIIIK*" /label="ytzA CDS" gene complement(2406672..2407055) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /label="ytzA gene" downshifts complement(2406686) /Source="Nicolas_upshifts" /id="D1497" /incds=0 /nref=181 /ntot=256 /MaxReadThrough="4.28884" /MaxDrop="5.74703" /score="18.319512" /energy="-13.8" /TU="NA" /idTUdmin="U2257" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2407056..2407147) /Source="Nicolas_S_feature" /locus_tag="new_2984696_2984787_c" /HighExp="G135, LBGtran, G150, LBGexp, M0t45, Lbexp, S0, G180, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1103" CDS complement(2407148..2408905) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /EC_number="2.7.1.40" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate kinase" /protein_id="NP_390796.1" /db_xref="EnsemblGenomes-Gn:BSU29180" /db_xref="EnsemblGenomes-Tr:CAB14878" /db_xref="GOA:P80885" /db_xref="InterPro:IPR001697" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR011037" /db_xref="InterPro:IPR015793" /db_xref="InterPro:IPR015795" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018209" /db_xref="InterPro:IPR036918" /db_xref="SubtiList:BG12661" /db_xref="UniProtKB/Swiss-Prot:P80885" /translation="MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHG ARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTD KISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNV PGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVIT ATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASR SEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKY RPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDL IVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGA VLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQ DITVDASRGAVYQGRASVL*" /label="pyk CDS" gene complement(2407148..2408905) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /label="pyk gene" CDS complement(2408948..2409907) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /EC_number="2.7.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12450869, 12622823, 12682299, 19193632, 20473954, 22198292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450869, 12622823, 12682299, 19193632, 20473954, 22198292; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phosphofructokinase" /protein_id="NP_390797.1" /db_xref="EnsemblGenomes-Gn:BSU29190" /db_xref="EnsemblGenomes-Tr:CAB14879" /db_xref="GOA:O34529" /db_xref="InterPro:IPR000023" /db_xref="InterPro:IPR012003" /db_xref="InterPro:IPR012828" /db_xref="InterPro:IPR015912" /db_xref="InterPro:IPR022953" /db_xref="InterPro:IPR035966" /db_xref="PDB:4A3S" /db_xref="SubtiList:BG12644" /db_xref="UniProtKB/Swiss-Prot:O34529" /translation="MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGL ISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGG DGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSH ERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGKKHSII IVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLL EGKGGRCVGIQNNKLVDHDIIEILETKHTVEQNMYQLSKELSI*" /label="pfkA CDS" gene complement(2408948..2409907) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /label="pfkA gene" S_feature complement(2409908..2410009) /Source="Nicolas_S_feature" /locus_tag="new_2987548_2987649_c" /HighExp="G150, LBGtran, LBGexp, Lbexp, dia0, G180, G135, Oxctl, LBGstat, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1104" promotor_-10 complement(2409998..2410017) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2410009) /Source="Nicolas_upshifts" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2410033..2410037) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2410091..2411068) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase alpha subunit)" /protein_id="NP_390798.1" /db_xref="EnsemblGenomes-Gn:BSU29200" /db_xref="EnsemblGenomes-Tr:CAB14880" /db_xref="GOA:O34847" /db_xref="InterPro:IPR001095" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12557" /db_xref="UniProtKB/Swiss-Prot:O34847" /translation="MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLA KLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIA KFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTK GAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLEN STYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVK LQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN*" /label="accA CDS" gene complement(2410091..2411068) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /label="accA gene" downshifts complement(2410118) /Source="Nicolas_upshifts" /id="D1498" /incds=0 /nref=48 /ntot=176 /MaxReadThrough="5.40549" /MaxDrop="5.53933" /score="-3.96100458" /energy="-6.8" /TU="U2259,U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2411053..2411925) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /EC_number="6.4.1.2" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 14594796, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase betasubunit)" /protein_id="NP_390799.2" /db_xref="EnsemblGenomes-Gn:BSU29210" /db_xref="EnsemblGenomes-Tr:CAB14881" /db_xref="GOA:C0SP93" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13926" /db_xref="UniProtKB/Swiss-Prot:C0SP93" /translation="MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKEL DKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDRE KTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFII FTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDY NFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLL DMHQTGGDIEWLQD*" /label="accD CDS" gene complement(2411053..2411925) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /label="accD gene" promotor_-35 2411887..2411892 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2411908..2411926 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2411912..2413086 /Source="Nicolas_S_feature" /locus_tag="new_2989552_2990726" /HighExp="S5, S8, S6, S7, C30, S4, C90, S3, T5.0H, BC" /AntisenseName="ytsJ" /AntisenseCor="-0.46008986922877199" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1105" upshifts 2411912 /Source="Nicolas_upshifts" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2411926..2412009) /Source="Nicolas_S_feature" /locus_tag="new_2989566_2989649_c" /HighExp="LBGstat, T4.0H, LBGtran, T5.0H, C30, dia15, M9-stat, Oxctl, LBGexp, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1106" promotor_-10 complement(2411998..2412017) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2412009) /Source="Nicolas_upshifts" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2412011..2412163) /Source="Nicolas_S_feature" /locus_tag="new_2989651_2989803_c" /HighExp="Diami, BC, dia15, Sw, dia5, M40t90, H2O2, S2, G/S, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1107" promotor_-35 complement(2412033..2412037) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2412165..2412259) /Source="Nicolas_S_feature" /locus_tag="new_2989805_2989899_c" /HighExp="dia15, LBGtran, LBGstat, Diami, LoTm, C90, GM 120, MG 60, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1108" downshifts complement(2412208) /Source="Nicolas_upshifts" /id="D1499" /incds=0 /nref=52 /ntot=158 /MaxReadThrough="7.72399" /MaxDrop="4.5863" /score="-3.96100458" /energy="-6.8" /TU="U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-2178" /isTUend="FALSE" /label="downshifts" CDS complement(2412260..2413492) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /EC_number="1.1.1.40" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 22740702, 23136871, 24325460, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 22740702, 23136871, 24325460, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic)" /protein_id="NP_390800.1" /db_xref="EnsemblGenomes-Gn:BSU29220" /db_xref="EnsemblGenomes-Tr:CAB14882" /db_xref="GOA:O34962" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG13922" /db_xref="UniProtKB/Swiss-Prot:O34962" /translation="MSLREEALHLHKVNQGKLESKSKVEVRNAKDLSLAYSPGVAEPC KDIHEDINKVYDYTMKGNMVAVVTDGTAVLGLGNIGPEAALPVMEGKAVLFKSFAGVD AFPIALNTNDVDKIVETVKLLEPTFGGVNLEDIAAPNCFIIEERLKKETNIPVFHDDQ HGTAIVTVAGLVNALKLSGKSMSSIKVVANGAGAAGIAIIKLLHHYGVRDIVMCDSKG AIYEGRPNGMNDVKNEVAKFTNQDRKDGSLKDVIVDADVFIGVSVAGALTKEMVQSMA KDPIIFAMANPNPEIMPEDAREAGASVVGTGRSDFPNQVNNVLAFPGIFRGALDVRAT HINEEMKIAAVEAIASLVSEDELSADYVIPAPFDKRVAPAVAKAVAKAAMETGVARIT VDPEEVAEKTRKLTIIGE*" /label="maeB CDS" gene complement(2412260..2413492) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /label="maeB gene" S_feature complement(2413493..2413609) /Source="Nicolas_S_feature" /locus_tag="new_2991133_2991249_c" /HighExp="dia15, Diami, LBGstat, H2O2, LBGtran, dia5, M40t45, Lbtran, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1109" promotor_-10 complement(2413597..2413616) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2413609) /Source="Nicolas_upshifts" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" CDS complement(2413629..2416976) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit), DnaE3" /protein_id="NP_390801.1" /db_xref="EnsemblGenomes-Gn:BSU29230" /db_xref="EnsemblGenomes-Tr:CAB14883" /db_xref="GOA:O34623" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR029460" /db_xref="SubtiList:BG12583" /db_xref="UniProtKB/Swiss-Prot:O34623" /translation="MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVM YGAIQFYKACKARGINPIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQ SKSKGGLKPKWLHSYREGIIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAF YFSYQPFKGNQVLSEQILKLSEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLT DAPAEDLPDLDLKPLEEMQNIYREHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDG TSADDYLTDICMEGLRSRFGKPDERYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHE KGIVTGPGRGSAAGSLVAYVLYITDVDPIKHHLLFERFLNPERVSMPDIDIDFPDTRR DEVIQYVQQKYGAMHVAQIITFGTLAAKAALRDVGRVFGVSPKEADQLAKLIPSRPGM TLDEARQQSPQLDKRLRESSLLQQVYSIARKIEGLPRHASTHAAGVVLSEEPLTDVVP LQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLRNLTLIESITSMIEKEENIKIDLSSIS YSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLKPSGLEDIVAVNALYRPGPMENIPL FIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIMMIASRMAGFSLGEADLLRRAVS KKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKFANYGFNRSHAVAYSMIGCQL AYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRILPPSVNKSSFPFTVENGS VRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKSVNRKMLEALIFSGAMD EFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKYVETEELPLVDLLAF EKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLLSKIKTIRTKTGQ NMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDKIQFIMSRAEL LEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQKQTIKLPES FHINADHQVLYRLKELLGQKNVVLKQW*" /label="dnaEC CDS" gene complement(2413629..2416976) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /label="dnaEC gene" promotor_-35 complement(2413630..2413637) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2414641..2414650 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2414662..2414677 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2414662 /Source="Nicolas_upshifts" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2414850..2414869) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2414869) /Source="Nicolas_upshifts" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2414883..2414890) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2417007..2417026) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2417025) /Source="Nicolas_upshifts" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" promotor_-35 complement(2417040..2417047) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2417065..2417070 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-35" upshifts 2417082 /Source="Nicolas_upshifts" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="upshifts" promotor_-10 2417086..2417104 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-10" CDS 2417116..2417457 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="membrane protein involved in a sporulation process" /protein_id="YP_003097771.1" /db_xref="EnsemblGenomes-Gn:BSU29239" /db_xref="EnsemblGenomes-Tr:CAX52677" /db_xref="GOA:C0H3P8" /db_xref="InterPro:IPR025689" /db_xref="UniProtKB/Swiss-Prot:C0H3P8" /translation="MDQEAGFMVNFINSYFIALGVLIGGALIGGLGAYLAGEPPLTAI TKLANRLKIWALVAAIGGTFDAVYSFERGILEGNTRDIFKQLLLIISAMGGAQSGWLI ISWLTQEHLSS*" /label="ytrH CDS" gene 2417116..2417457 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /label="ytrH gene" CDS 2417454..2417957 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="protein involved in sporulation" /protein_id="NP_390802.3" /db_xref="EnsemblGenomes-Gn:BSU29240" /db_xref="EnsemblGenomes-Tr:CAB14884" /db_xref="GOA:O34460" /db_xref="SubtiList:BG13917" /db_xref="UniProtKB/Swiss-Prot:O34460" /translation="MRVPQHYKKPGWQRFFAGMMCGAVISWFFFLFTYGTFQEEQVSL IEKQKEHVKDLNNQISIYQEDLHKLNEDNKRKLLIQSVSVKLLNGDKYKISQPDKTKF EEHVKDDISEVITKDIESVYQTKDLLKRTIENKVYMINEKKYEATVRELIIYTRLTVE LEISFAT*" /label="ytrI CDS" gene 2417454..2417957 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /label="ytrI gene" promotor_-35 2417990..2417993 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2418008..2418027 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2418008 /Source="Nicolas_upshifts" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" CDS 2418059..2418250 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative sporulation-related conserved protein" /protein_id="YP_003097772.1" /db_xref="EnsemblGenomes-Gn:BSU29249" /db_xref="EnsemblGenomes-Tr:CAX52678" /db_xref="UniProtKB/Swiss-Prot:C0H3P9" /translation="MEVYSDRQLAKDQAARLRQGFSAYAETNSLASLIKKELQSHNLQ VYEDLTDFGCWFIPVTDEH*" /label="ytzJ CDS" gene 2418059..2418250 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /label="ytzJ gene" downshifts complement(2418060) /Source="Nicolas_upshifts" /id="D1500" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.45109" /MaxDrop="3.19151" /score="-1.37123732" /energy="-6.5" /TU="NA" /idTUdmin="U2268" /TUdmin=220 /isTUend="FALSE" /label="downshifts" downshifts 2418226 /Source="Nicolas_upshifts" /id="D1501" /incds=0 /nref=15 /ntot=107 /MaxReadThrough="6.88261" /MaxDrop="6.74738" /score="-8.58003897" /energy="-4" /TU="U2265" /idTUdmin="U2264" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2418268..2419209) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /EC_number="3.1.3.7" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17586819, 19553197, 22102036, 26735940, 28894100" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17586819, 19553197, 22102036, 26735940, 28894100; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nanoRNase (oligoribonuclease) (3'->5'short substrates, 5'->3' long substrates), 3',5'-bisphosphate nucleotidase" /protein_id="NP_390803.1" /db_xref="EnsemblGenomes-Gn:BSU29250" /db_xref="EnsemblGenomes-Tr:CAB14885" /db_xref="GOA:O34600" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="PDB:5IPP" /db_xref="PDB:5IUF" /db_xref="PDB:5IZO" /db_xref="PDB:5J21" /db_xref="SubtiList:BG13910" /db_xref="UniProtKB/Swiss-Prot:O34600" /translation="MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPE KNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKID HHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRF LFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASV FIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLA RKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE*" /label="nrnA CDS" gene complement(2418268..2419209) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /label="nrnA gene" S_feature 2418271..2418642 /Source="Nicolas_S_feature" /locus_tag="new_2995911_2996282" /HighExp="Lbstat, S2, M0t90, M40t90, nit, ferm, S3, BT, M9-stat, S0" /AntisenseName="nrnA" /AntisenseCor="-0.77648424268923499" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1110" downshifts complement(2418303) /Source="Nicolas_upshifts" /id="D1502" /incds=0 /nref=25 /ntot=163 /MaxReadThrough="3.12169" /MaxDrop="3.09205" /score="22.5196409" /energy="-7.9" /TU="U2268" /idTUdmin="U2269" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2418611..2418620 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2418634..2418653 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2418644..2419038 /Source="Nicolas_S_feature" /locus_tag="new_2996284_2996678" /HighExp="Lbstat, S2, S7, S8, S6, nit, ferm, M0t90, BT, M40t90" /AntisenseName="nrnA" /AntisenseCor="-0.85531073541330804" /AntisenseRegPval="-77.5" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1111" upshifts 2418644 /Source="Nicolas_upshifts" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2419000..2419006 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2419022..2419041 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2419040..2419339 /Source="Nicolas_S_feature" /locus_tag="new_2996680_2996979" /HighExp="Lbstat, S8, S7, S6, S2, Etha, nit, ferm, BT, M0t90" /AntisenseName="nrnA" /AntisenseCor="-0.84034645112995598" /AntisenseRegPval="-72.2" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1112" upshifts 2419040 /Source="Nicolas_upshifts" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2419228..2419247) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2419244) /Source="Nicolas_upshifts" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2419246..2419660) /Source="Nicolas_S_feature" /locus_tag="new_2996886_2997300_c" /HighExp="LBGtran, HiTm, G180, G135, G150, Lbtran, LBGexp, Mt0, Paraq, dia0" /AntisenseName="ytpI" /AntisenseCor="-0.70134306018551296" /AntisenseRegPval="-40.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1113" promotor_-35 complement(2419262..2419265) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2419340..2419642 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390804.1" /db_xref="EnsemblGenomes-Gn:BSU29260" /db_xref="EnsemblGenomes-Tr:CAB14886" /db_xref="GOA:O34922" /db_xref="InterPro:IPR025618" /db_xref="SubtiList:BG13902" /db_xref="UniProtKB/Swiss-Prot:O34922" /translation="MLVLVFLIGLSACFYVYYKVKGVRAKPSLAKEICSAKSSMALGS LVLFYGLNQMILFHSVLTLVIGGIFIVIGAGSAWAGYKAFRHYNPLHAKEAERDHA*" /label="ytpI CDS" gene 2419340..2419642 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /label="ytpI gene" S_feature 2419643..2421438 /Source="Nicolas_S_feature" /locus_tag="new_2997283_2999078" /HighExp="S8, S6, S7, Lbstat, B36, nit, ferm, T1.0H, C30, S5" /AntisenseName="ytoI" /AntisenseCor="-0.55304378374907204" /AntisenseRegPval="-22.2" /CDS_PredictionProba="0.89152299999999995" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1114" CDS complement(2419661..2420980) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26296725" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390805.1" /db_xref="EnsemblGenomes-Gn:BSU29270" /db_xref="EnsemblGenomes-Tr:CAB14887" /db_xref="GOA:O34921" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR010766" /db_xref="InterPro:IPR028979" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13897" /db_xref="UniProtKB/Swiss-Prot:O34921" /translation="MATKHEQILTYIDSLPVGEKISVRRIAKEMKVSEGTAYRAIKEA ENKGFVSTIERVGTIRIEQKKKENIEKLTYAEVVNVIDGQVLGGRAGLHKTLNKFVIG AMELDAMMRYTAAGNLLIVGNRINAHRQALEAGAAVLVTGGFNTDDSIVQLADELELP ILSTSYDTFTVAAMINRAIYDQLIKKEIVLVEDILTPADRTVYLSPKDKLEKWYEKNF ETGHGRFPVVDDQMKIHGILTSKDIAGHDRNASIEKVMTKNPVTVIGKTSVASAAQMM VWEGIEVLPVTDGHQKLIGMISRQDVLKALQMIQKQPQVGEKLDDIVSRGFKDEGDDK EDQTVYEYEVTPQMTNQLGTISYGVFTTILTQAANRFLRSKKRGELVIESITIFFLKP VQMESVIEVKPRILEAGRKFGKMEVEVHSQGHIVSKAMLMVQLMERS*" /label="ytoI CDS" gene complement(2419661..2420980) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /label="ytoI gene" promotor_-10 complement(2421006..2421025) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2421027) /Source="Nicolas_upshifts" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2421040..2421045) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2421156..2422058) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390806.1" /db_xref="EnsemblGenomes-Gn:BSU29280" /db_xref="EnsemblGenomes-Tr:CAB14888" /db_xref="GOA:O34430" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13894" /db_xref="UniProtKB/Swiss-Prot:O34430" /translation="MKKLIVFAFIGLLSQLIDGSLGMAYGVTSTSLLLAFGITPAVAS ASVHLAEVVTTAASGVSHIKFGNVDKQTVYQLVIPGSIGAFLGAAFLSQLPGDVAKPY ISLFLLLLGGYVLIRFLFQYKPALEKKHVPLNRKQSIPLGVIAGFADATGGGGWGPVT TPILLSRKGLSPRKVVGTVDTSEFAIAVSATAGFLISLGWEDVNWLWVFSLMAGGIIA APIAAWLVQKFHPQLMGVLVGGFIILVNARTLINEWIANTAVHPLIYTAIGAIWLSAV LFVLSKIGNRNIVKTAVDVHLKEK*" /label="ytnM CDS" gene complement(2421156..2422058) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /label="ytnM gene" CDS complement(2422077..2423327) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10588044, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10588044, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-alkyl-N-acetyl-metabolite deacetylase" /protein_id="NP_390807.1" /db_xref="EnsemblGenomes-Gn:BSU29290" /db_xref="EnsemblGenomes-Tr:CAB14889" /db_xref="GOA:O34980" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12596" /db_xref="UniProtKB/Swiss-Prot:O34980" /translation="MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGI RRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRA DIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQ PAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEG KGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDT VVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLV RDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAII KASYFLYESAKRLLDSNEESKISD*" /label="sndA CDS" gene complement(2422077..2423327) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /label="sndA gene" CDS complement(2423345..2424037) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FMN-riboswitch-binding activator of rib genes" /protein_id="NP_390808.1" /db_xref="EnsemblGenomes-Gn:BSU29300" /db_xref="EnsemblGenomes-Tr:CAB14890" /db_xref="GOA:P94465" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11969" /db_xref="UniProtKB/Swiss-Prot:P94465" /translation="MTIIAGTVVKGKQLGRKLGFPTANVDAKIHGLRNGVYGVLATVN HQFHLGVMNIGVKPTVGSNLEKTLEIFLFDFHRDIYGEKIECSILFKIREERRFDSLE SLTKQIKKDISCVAKRFELIGIMAPNKKESLLSHQELNLPDLCFYKKCNNLYGVNRGV YNVIDNWFFEYGITQVAYRRIYILSFLSFLKEDNPKVSSKYIRFGAGGLADKLNRFIS SYVEESEENILG*" /label="ribR CDS" gene complement(2423345..2424037) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /label="ribR gene" CDS complement(2424084..2425412) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390809.1" /db_xref="EnsemblGenomes-Gn:BSU29310" /db_xref="EnsemblGenomes-Tr:CAB14891" /db_xref="GOA:O34974" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="PDB:1TVL" /db_xref="PDB:1YW1" /db_xref="SubtiList:BG13893" /db_xref="UniProtKB/Swiss-Prot:O34974" /translation="MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQ TAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTE PFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVR GLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAG SSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVA DTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQST TDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDI PGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH*" /label="cmoJ CDS" gene complement(2424084..2425412) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /label="cmoJ gene" CDS complement(2425409..2425690) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redoxin" /protein_id="NP_390810.1" /db_xref="EnsemblGenomes-Gn:BSU29320" /db_xref="EnsemblGenomes-Tr:CAB14892" /db_xref="GOA:O34639" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13892" /db_xref="UniProtKB/Swiss-Prot:O34639" /translation="MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLR DILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR*" /label="cmoI CDS" gene complement(2425409..2425690) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /label="cmoI gene" CDS complement(2425705..2426709) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9836433, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9836433, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390811.1" /db_xref="EnsemblGenomes-Gn:BSU29330" /db_xref="EnsemblGenomes-Tr:CAB14893" /db_xref="GOA:O34846" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG13888" /db_xref="UniProtKB/Swiss-Prot:O34846" /translation="MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAE HHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRI DLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQ VDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAE FHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDII VQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR *" /label="cmoO CDS" gene complement(2425705..2426709) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /label="cmoO gene" CDS complement(2426706..2427485) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino-acid ABC transporter (ATP-binding protein)" /protein_id="NP_390812.1" /db_xref="EnsemblGenomes-Gn:BSU29340" /db_xref="EnsemblGenomes-Tr:CAB14894" /db_xref="GOA:O34900" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG12604" /db_xref="UniProtKB/Swiss-Prot:O34900" /translation="MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFL RCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVM EGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDV LLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIV EQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI*" /label="tcyN CDS" gene complement(2426706..2427485) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /label="tcyN gene" CDS complement(2427482..2428189) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390813.1" /db_xref="EnsemblGenomes-Gn:BSU29350" /db_xref="EnsemblGenomes-Tr:CAB14895" /db_xref="GOA:O34931" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13887" /db_xref="UniProtKB/Swiss-Prot:O34931" /translation="MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVR IFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSM FVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIP NFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILES ANGVLERKAARFQGGTL*" /label="tcyM CDS" gene complement(2427482..2428189) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /label="tcyM gene" CDS complement(2428219..2428938) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390814.1" /db_xref="EnsemblGenomes-Gn:BSU29360" /db_xref="EnsemblGenomes-Tr:CAB14896" /db_xref="GOA:O34315" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13886" /db_xref="UniProtKB/Swiss-Prot:O34315" /translation="MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLAL PRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVA TYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGN MVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRV AEKRIKKNQTRIVTVFDMNIH*" /label="tcyL CDS" gene complement(2428219..2428938) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /label="tcyL gene" promotor_-35 2428764..2428771 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2428786..2428805 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2428786 /Source="Nicolas_upshifts" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2428960..2429772) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 22720735, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 22720735, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390815.1" /db_xref="EnsemblGenomes-Gn:BSU29370" /db_xref="EnsemblGenomes-Tr:CAB14897" /db_xref="GOA:O34852" /db_xref="InterPro:IPR001638" /db_xref="PDB:2O1M" /db_xref="SubtiList:BG13885" /db_xref="UniProtKB/Swiss-Prot:O34852" /translation="MKTKTAFMAILFSLITVLSACGAGSQTTGAGQKKVQTITVGTGT QFPNICFIDEKGDLTGYDVELIKELDKRLPHYKFTFKTMEFSNLLVSLGQHKVDIVAH QMEKSKEREKKFLFNKVAYNHFPLKITVLQNNDTIRGIEDLKGKRVITSATSNGALVL KKWNEDNGRPFEIAYEGQGANETANQLKSGRADATISTPFAVDFQNKTSTIKEKTVGN VLSNAKVYFMFNKNEQTLSDDIDKALQEIIDDGTLKRLSLKWLGDDYSKEQY*" /label="tcyK CDS" gene complement(2428960..2429772) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /label="tcyK gene" CDS complement(2429786..2430595) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390816.1" /db_xref="EnsemblGenomes-Gn:BSU29380" /db_xref="EnsemblGenomes-Tr:CAB14898" /db_xref="GOA:O34406" /db_xref="InterPro:IPR001638" /db_xref="SubtiList:BG13884" /db_xref="UniProtKB/Swiss-Prot:O34406" /translation="MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFP NIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMA KNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKY NKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLL DTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK*" /label="tcyJ CDS" gene complement(2429786..2430595) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /label="tcyJ gene" CDS complement(2430609..2431145) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyltransferase acting on sulfur compounds" /protein_id="NP_390817.1" /db_xref="EnsemblGenomes-Gn:BSU29390" /db_xref="EnsemblGenomes-Tr:CAB14899" /db_xref="GOA:O34350" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13883" /db_xref="UniProtKB/Swiss-Prot:O34350" /translation="MSDDIFRLATVEDASELLKLVNSAFQPIRQLDIDWPSTRADIQM VSENIEHHSAIVLERDGKLISTITIRFPWESETPPSKYPFVWWFATLPEYKGQGAGSK LLTYVEEKVLRDMLKAPALTLGTSARKHPWLADMYRRRGYEVYFEQEKDGDIGVMMHK VLIPERFNPTLLGAPSWA*" /label="snaA CDS" gene complement(2430609..2431145) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /label="snaA gene" promotor_-35 2431182..2431189 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2431200..2431219) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2431203..2431222 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2431206..2431297 /Source="Nicolas_S_feature" /locus_tag="new_3008846_3008937" /HighExp="dia5, MG 5, UNK1, MG t5, MG 10, B60, dia0, nit, Diami, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1115" upshifts 2431206 /Source="Nicolas_upshifts" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2431216) /Source="Nicolas_upshifts" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2431233..2431240) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2431298..2432224 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of operon snaA-ytnM degrading cysteine-containing compounds (AscR-N-acetylcysteine)" /protein_id="NP_390818.1" /db_xref="EnsemblGenomes-Gn:BSU29400" /db_xref="EnsemblGenomes-Tr:CAB14900" /db_xref="GOA:O35038" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13877" /db_xref="UniProtKB/Swiss-Prot:O35038" /translation="MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLG VLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTAS LIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFF YDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKM ELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHF DRATKDLIARITKRFQQRSKELEGTSDKTITG*" /label="ascR CDS" gene 2431298..2432224 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /label="ascR gene" S_feature complement(2431700..2432229) /Source="Nicolas_S_feature" /locus_tag="new_3009340_3009869_c" /HighExp="Etha, dia15, dia5, H2O2, M9-stat, M40t90, Sw, Gly, M0t90, Cold" /AntisenseName="ytlI" /AntisenseCor="-7.8012588423369304E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1116" downshifts complement(2432274) /Source="Nicolas_upshifts" /id="D1503" /incds=0 /nref=142 /ntot=251 /MaxReadThrough="4.32965" /MaxDrop="5.01142" /score="39.1547987" /energy="-16.5" /TU="U2273" /idTUdmin="U2274" /TUdmin=20 /isTUend="TRUE" /label="downshifts" CDS complement(2432275..2432958) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390819.2" /db_xref="EnsemblGenomes-Gn:BSU29410" /db_xref="EnsemblGenomes-Tr:CAB14901" /db_xref="GOA:Q795U4" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR022877" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13871" /db_xref="UniProtKB/Swiss-Prot:Q795U4" /translation="MKVTYHGHSVITVETKDHHIIFDPFLTGNSLTDIKPEDVKADVI LLTHGHNDHVGDTEQIAKQNNALVIAPNELAVYLGWKGLNVHPMHIGGSRQFDFGKVK LTQAFHGSAITDEENKTITYTGMPAGILLTVEDKTIFHAGDTALFSDMKLIGELNHID LAFLPIGDNFTMGPEDAKLAAEWLRAKQVVPVHYNTFPVIEQDPEAFADSLPGGVGKV MSVGETIEL*" /label="ytkL CDS" gene complement(2432275..2432958) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /label="ytkL gene" S_feature complement(2432959..2433020) /Source="Nicolas_S_feature" /locus_tag="new_3010599_3010660_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, M0t90, M40t90, Salt, LBGtran, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1117" CDS complement(2433021..2433788) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_390820.1" /db_xref="EnsemblGenomes-Gn:BSU29420" /db_xref="EnsemblGenomes-Tr:CAB14902" /db_xref="GOA:O34308" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13870" /db_xref="UniProtKB/Swiss-Prot:O34308" /translation="MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKE ACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTD DEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGE DIARIIAFLCEENSDLVTGTVIEATGGLNVINKNQTT*" /label="ytkK CDS" gene complement(2433021..2433788) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /label="ytkK gene" promotor_-10 complement(2433833..2433852) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2433855) /Source="Nicolas_upshifts" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2433868..2433870) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2433915..2434151) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11423008" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390821.3" /db_xref="EnsemblGenomes-Gn:BSU29430" /db_xref="EnsemblGenomes-Tr:CAB14903" /db_xref="SubtiList:BG13938" /db_xref="UniProtKB/Swiss-Prot:O34503" /translation="MKKRKLAWQQEFVKISFIKSRHYSQPTSIMMGGRMMKKEPERYI YDEQESQETTRLISEAYQSGYVDMPDQESSSPAE*" /label="ytzD CDS" gene complement(2433915..2434151) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /label="ytzD gene" downshifts 2434000 /Source="Nicolas_upshifts" /id="D1504" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="0.55049" /MaxDrop="4.17437" /score="-5.88070891" /energy="-8.9" /TU="NA" /idTUdmin="U2271" /TUdmin=1782 /isTUend="FALSE" /label="downshifts" downshifts complement(2434020) /Source="Nicolas_upshifts" /id="D1505" /incds=0 /nref=199 /ntot=288 /MaxReadThrough="5.44889" /MaxDrop="6.29233" /score="21.2322542" /energy="-8.5" /TU="U2274" /idTUdmin="U2274" /TUdmin="-1726" /isTUend="FALSE" /label="downshifts" CDS complement(2434111..2435496) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /EC_number="4.3.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 9890879, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 9890879, 11423008; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate lyase" /protein_id="NP_390822.1" /db_xref="EnsemblGenomes-Gn:BSU29440" /db_xref="EnsemblGenomes-Tr:CAB14904" /db_xref="GOA:O34858" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR009049" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="InterPro:IPR029419" /db_xref="SubtiList:BG12571" /db_xref="UniProtKB/Swiss-Prot:O34858" /translation="MKKLWGGRFQKTPEKWVDEFGASISFDQNLVAEDITGSLAHAAM LKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLIDEIGPLGGK LHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPGYTHLQRA QPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTFPIDRDYSAELLGF DAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIELDDTYATG SSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKT VEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLV YTCIERGIYLSDMPFGEFQQASTLFEEDIYTVLDPYYAVEKRMSAGGTGFKQVEQALE KAKACVAAGVC*" /label="argH CDS" gene complement(2434111..2435496) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /label="argH gene" CDS complement(2435493..2436704) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /EC_number="6.3.4.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 11423008, 12963366, 17611193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 11423008, 12963366, 17611193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate synthase" /protein_id="NP_390823.1" /db_xref="EnsemblGenomes-Gn:BSU29450" /db_xref="EnsemblGenomes-Tr:CAB14905" /db_xref="GOA:O34347" /db_xref="InterPro:IPR001518" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018223" /db_xref="InterPro:IPR023434" /db_xref="InterPro:IPR024074" /db_xref="SubtiList:BG12570" /db_xref="UniProtKB/Swiss-Prot:O34347" /translation="MSEQKKVVLAYSGGLDTSVAIKWLQEQGYNVIACCLDVGEGKDL AFVQQKALEVGATNSYVIDAKEEFAQDYALISLQAHTMYEGKYPLVSALSRPLIAKKL VEIAEKEDAQAIAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTAPLEKTPDTPEVI EIAFEQGVPVSIDGVSYSLSELILKLNEMAGAHGVGRIDHVENRLVGIKSREVYECPG AMTLIKAHKELEDLTLVKEVAHFKPIIEQKMSEIIYNGLWFSPLKDALHAFLKETQKH VTGIVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVN SIVKKKEQIKA*" /label="argG CDS" gene complement(2435493..2436704) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /label="argG gene" S_feature complement(2436705..2436782) /Source="Nicolas_S_feature" /locus_tag="new_3014345_3014422_c" /HighExp="S1, MG 15, T3.0H, T3.30H, T4.0H, T5.0H, BMM, T2.30H, T-0.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1118" promotor_-10 complement(2436775..2436794) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2436781) /Source="Nicolas_upshifts" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2436809..2436816) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2436874..2437386) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15269205, 20054111, 23680484; Product type f: factor" /codon_start=1 /transl_table=11 /product="molybdopterin GTP-binding precursor Z biosynthesis component" /protein_id="NP_390824.1" /db_xref="EnsemblGenomes-Gn:BSU29460" /db_xref="EnsemblGenomes-Tr:CAB14924" /db_xref="GOA:O34457" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008284" /db_xref="InterPro:IPR012245" /db_xref="InterPro:IPR036425" /db_xref="SubtiList:BG12618" /db_xref="UniProtKB/Swiss-Prot:O34457" /translation="MSVQEHKQEAPDIVRCKVITVSDTRTDETDKSGKLMISFLEEAG HHIAAYEIVKDEKDALQRSVLAGCMDEQTDAVLLNGGTGIADRDVTIEAITPLFSKEL PGFGEIFRMLSYTEDIGSAAIMSRATAGVIQHTAVFSTPGSSGAVKLAMNKLIIPELA HVVREIRKDK*" /label="moaB CDS" gene complement(2436874..2437386) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /label="moaB gene" downshifts complement(2436892) /Source="Nicolas_upshifts" /id="D1506" /incds=0 /nref=122 /ntot=221 /MaxReadThrough="1.48097" /MaxDrop="4.78155" /score="25.7910606" /energy="-10.8" /TU="NA" /idTUdmin="U2275" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2437412..2437431) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2437420) /Source="Nicolas_upshifts" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2437445..2437452) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2437471..2438658) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /EC_number="2.7.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8226682, 9811655, 11244084, 16995897, 19019159, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226682, 9811655, 11244084, 16995897, 19019159, 26098117; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="NP_390825.1" /db_xref="EnsemblGenomes-Gn:BSU29470" /db_xref="EnsemblGenomes-Tr:CAB14925" /db_xref="GOA:P37877" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR004372" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG10813" /db_xref="UniProtKB/Swiss-Prot:P37877" /translation="MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTI SVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVL LTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEG GKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGIS GFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENS VEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVR LAK*" /label="ackA CDS" gene complement(2437471..2438658) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /label="ackA gene" downshifts complement(2437486) /Source="Nicolas_upshifts" /id="D1507" /incds=0 /nref=13 /ntot=117 /MaxReadThrough="5.03131" /MaxDrop="3.1641" /score="19.2403206" /energy="-9.9" /TU="U2276" /idTUdmin="U2277" /TUdmin=242 /isTUend="FALSE" /label="downshifts" S_feature complement(2438659..2438763) /Source="Nicolas_S_feature" /locus_tag="new_3016299_3016403_c" /HighExp="dia0, Lbexp, LBGtran, Oxctl, LPh, M0t45, HPh, Paraq, H2O2, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1119" promotor_-10 complement(2438748..2438767) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2438763) /Source="Nicolas_upshifts" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2438765..2438894) /Source="Nicolas_S_feature" /locus_tag="new_3016405_3016534_c" /HighExp="S5, S6, S7, S8, S4, dia5, BT, H2O2, dia15, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1120" promotor_-35 complement(2438783..2438787) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2438831..2439034) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513997.1" /translation="MMNGLKKKSKCFKSSLDSRMRSMPKLLLFMLLKTGLDELNPALK HKIQREKPQIVSVHQYKTYSECV*" /label="hypothetical protein CDS" gene complement(2438831..2439034) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /label="gene" promotor_-10 complement(2438892..2438903) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2438894) /Source="Nicolas_upshifts" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2438918..2438924) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2439006..2439995) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid methyltransferase" /protein_id="NP_390826.1" /db_xref="EnsemblGenomes-Gn:BSU29480" /db_xref="EnsemblGenomes-Tr:CAB14926" /db_xref="GOA:P37876" /db_xref="InterPro:IPR003356" /db_xref="InterPro:IPR016843" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10812" /db_xref="UniProtKB/Swiss-Prot:P37876" /translation="MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKT DQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTI GLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIA YAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSF AHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFK DEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK*" /label="ytxK CDS" gene complement(2439006..2439995) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /label="ytxK gene" downshifts complement(2439024) /Source="Nicolas_upshifts" /id="D1508" /incds=0 /nref=158 /ntot=243 /MaxReadThrough="3.51469" /MaxDrop="5.25938" /score="-4.33730173" /energy="-13.3" /TU="NA" /idTUdmin="U2279" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2440056..2440559) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486061, 18588855, 18588855, 23899494, 25355936, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486061, 18588855, 18588855, 23899494, 25355936, 25852656; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol peroxidase (lipid hydroperoxide reductase)" /protein_id="NP_390827.1" /db_xref="EnsemblGenomes-Gn:BSU29490" /db_xref="EnsemblGenomes-Tr:CAB14927" /db_xref="GOA:P80864" /db_xref="InterPro:IPR002065" /db_xref="InterPro:IPR013740" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR018219" /db_xref="InterPro:IPR036249" /db_xref="PDB:2JSY" /db_xref="PDB:2JSZ" /db_xref="SubtiList:BG13855" /db_xref="UniProtKB/Swiss-Prot:P80864" /translation="MAEITFKGGPVTLVGQEVKVGDQAPDFTVLTNSLEEKSLADMKG KVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKV ETLSDHRDMSFGEAFGVYIKELRLLARSVFVLDENGKVVYAEYVSEATNHPNYEKPIE AAKALVK*" /label="tpx CDS" gene complement(2440056..2440559) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /label="tpx gene" downshifts complement(2440062) /Source="Nicolas_upshifts" /id="D1509" /incds=0 /nref=53 /ntot=241 /MaxReadThrough="6.94509" /MaxDrop="4.3179" /score="9.29337297" /energy="-10.1" /TU="U2279" /idTUdmin="U2280" /TUdmin=548 /isTUend="FALSE" /label="downshifts" promotor_no_box 2440276..2440376 /Source="Nicolas_upshift_promotors" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2440336 /Source="Nicolas_upshifts" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2440555 /Source="Nicolas_upshifts" /id="D1510" /incds=0 /nref=86 /ntot=184 /MaxReadThrough="2.23568" /MaxDrop="5.49495" /score="20.1242958" /energy="-12.7" /TU="NA" /idTUdmin="U2278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2440582..2440601) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2440598) /Source="Nicolas_upshifts" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2440615..2440622) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2440669..2441124) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /experiment="publication(s) with functional evidences, PMID:23921501, 25790435, 27881417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23921501, 25790435, 27881417; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination-associated protein" /protein_id="NP_390828.1" /db_xref="EnsemblGenomes-Gn:BSU29500" /db_xref="EnsemblGenomes-Tr:CAB14928" /db_xref="GOA:O34806" /db_xref="InterPro:IPR014229" /db_xref="SubtiList:BG13849" /db_xref="UniProtKB/Swiss-Prot:O34806" /translation="MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSK VGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRM LHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY*" /label="gerW CDS" gene complement(2440669..2441124) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /label="gerW gene" downshifts complement(2440697) /Source="Nicolas_upshifts" /id="D1511" /incds=0 /nref=38 /ntot=91 /MaxReadThrough="3.69502" /MaxDrop="5.65648" /score="26.1939476" /energy="-12.7" /TU="U2280" /idTUdmin="U2280" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" CDS complement(2441138..2441818) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390829.1" /db_xref="EnsemblGenomes-Gn:BSU29510" /db_xref="EnsemblGenomes-Tr:CAB14929" /db_xref="InterPro:IPR021338" /db_xref="SubtiList:BG13848" /db_xref="UniProtKB/Swiss-Prot:O34917" /translation="MVYVLTAILILIGIVLLLRMKIHVALEYLHADDNDKLTLKITAL FGLIRIKKTIPAIKVNKEDGTVDIKQKTESKMKKSSGKKKITQNDVQQSINKIEMLLH QVTRLRKISASFLAHLHITKLEWVTVIGIQDAAVTGVLTGAVWGVKGGIAAMLYDHLD FVNKPVYEVIPSFQVPVSKTHFQCIFFFRFGHAMLAAFKFVKYGRELSVLKKNPSARM TSKNDSSV*" /label="ytfI CDS" gene complement(2441138..2441818) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /label="ytfI gene" upshifts complement(2441230) /Source="Nicolas_upshifts" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="upshifts" promotor_-10 complement(2441237..2441248) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-10" promotor_-35 complement(2441263..2441269) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-35" downshifts complement(2441556) /Source="Nicolas_upshifts" /id="D1512" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.64036" /MaxDrop="2.98792" /score="28.0381876" /energy="-11.8" /TU="U2281" /idTUdmin="U2281" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2441831..2441849) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-10" upshifts complement(2441845) /Source="Nicolas_upshifts" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="upshifts" promotor_-35 complement(2441864..2441869) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-35" CDS complement(2441893..2442387) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390830.1" /db_xref="EnsemblGenomes-Gn:BSU29520" /db_xref="EnsemblGenomes-Tr:CAB14930" /db_xref="GOA:O34424" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG13840" /db_xref="UniProtKB/Swiss-Prot:O34424" /translation="MDATYEELERNDIKGPQEAELLTHAYAGFWVRFWAFLLDWLVIW GLNHLLVSPLFTVLDLPKTSGMFTFSAYSVTTLIVYLAYFALMTKYFRQTLGKMVFGL KVVSVKQDSKLTWSTVIFREVVGRYIDKIWILYIVVAFSPTKQGIHDYIADTTVVHEK LYRK*" /label="yteJ CDS" gene complement(2441893..2442387) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /label="yteJ gene" downshifts complement(2441908) /Source="Nicolas_upshifts" /id="D1513" /incds=0 /nref=240 /ntot=258 /MaxReadThrough="1.43721" /MaxDrop="6.8315" /score="28.0381876" /energy="-11.8" /TU="NA" /idTUdmin="U2282" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2442400..2443407) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9987136, 10455123, 16484219, 22472423, 23155385, 24228759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 10455123, 16484219, 22472423, 23155385, 24228759; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="signal peptide peptidase" /protein_id="NP_390831.1" /db_xref="EnsemblGenomes-Gn:BSU29530" /db_xref="EnsemblGenomes-Tr:CAB14931" /db_xref="GOA:O34525" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /db_xref="InterPro:IPR029045" /db_xref="PDB:3RST" /db_xref="PDB:4KWB" /db_xref="SubtiList:BG13839" /db_xref="UniProtKB/Swiss-Prot:O34525" /translation="MNAKRWIALVIALGIFGVSIIVSISMSFFESVKGAQTDLTSLTD ESQEKTLENGSPSSKIAVLEVSGTIQDNGDSSSLLGADGYNHRTFLKNLERAKDDKTV KGIVLKVNSPGGGVYESAEIHKKLEEIKKETKKPIYVSMGSMAASGGYYISTAADKIF ATPETLTGSLGVIMESVNYSKLADKLGISFETIKSGAHKDIMSPSREMTKEEKNIMQS MVDNSYEGFVDVISKGRGMPKAEVKKIADGRVYDGRQAKKLNLVDELGFYDDTITAMK KDHKDLKNASVISYEESFGLGSLFSMGANKMFKSEIDFLNMREILSQSGSPRMMYLYA K*" /label="sppA CDS" gene complement(2442400..2443407) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /label="sppA gene" promotor_-10 complement(2443431..2443446) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2443448) /Source="Nicolas_upshifts" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2443450..2443529) /Source="Nicolas_S_feature" /locus_tag="new_3021090_3021169_c" /HighExp="LBGexp, Oxctl, LBGtran, dia0, H2O2, dia15, G180, G150, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1121" promotor_-35 complement(2443458..2443467) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2443507..2443526 /Source="Nicolas_upshift_promotors" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2443517 /Source="Nicolas_upshifts" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2443522..2443541) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2443526..2443592 /Source="Nicolas_S_feature" /locus_tag="new_3021166_3021232" /HighExp="M0t90, Sw, M9-stat, BC, M40t90, T4.0H, T2.30H, S1, T3.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1122" upshifts complement(2443529) /Source="Nicolas_upshifts" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2443557..2443561) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2443593..2444396 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /EC_number="2.7.1.23" /function="16.7: Manage energy" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897004, 16233726, 16511117, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase" /protein_id="NP_390832.1" /db_xref="EnsemblGenomes-Gn:BSU29540" /db_xref="EnsemblGenomes-Tr:CAB14932" /db_xref="GOA:O34934" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13837" /db_xref="UniProtKB/Swiss-Prot:O34934" /translation="MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDAN IIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQI EVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTP TGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDG NEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL*" /label="ppnKB CDS" gene 2443593..2444396 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /label="ppnKB gene" downshifts 2444326 /Source="Nicolas_upshifts" /id="D1514" /incds=1 /nref=46 /ntot=222 /MaxReadThrough="5.39036" /MaxDrop="3.90238" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-124" /isTUend="FALSE" /label="downshifts" downshifts 2444384 /Source="Nicolas_upshifts" /id="D1515" /incds=0 /nref=6 /ntot=54 /MaxReadThrough="3.14676" /MaxDrop="4.64552" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2444428..2446017) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19433221, 20386924, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-substituted formamide deformylase, dihydropyrimidinase or isoaspartyl peptidase" /protein_id="NP_390833.1" /db_xref="EnsemblGenomes-Gn:BSU29550" /db_xref="EnsemblGenomes-Tr:CAB14933" /db_xref="GOA:O34355" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR013108" /db_xref="InterPro:IPR032466" /db_xref="InterPro:IPR033932" /db_xref="SubtiList:BG13835" /db_xref="UniProtKB/Swiss-Prot:O34355" /translation="MKAIWHGGFIYTMLEEGDRTEAVYVEDGVIKGTGSYERLKEKYG SPETEEISLNGAVMFPGFVDSHLHLIGHGEKQLQLDLSALTSKDSILQAAKERERQLP KNDWLIGEGWNENQFETPDYLTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGIS RNTPDPDGGVIVKDANGEPTGLLFDKAQDLILKAVPPVSQHYVDEALTAAIKDCWTKG LTGGHSEDLSYYGDVSVPMKAYEKAAAGGKYPFRCHLLVHHEAVDRWEQLEKLSGPYV EFGAMKIFADGALGGRTALLKEPYQDDPSTNGVQVHDDETLGRLIRKAREKGMEVAVH AIGDLAFEKVLNAIEKHPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASD FPWVIDRLGKDRMKTAFAWKTLISKGILCAGGSDAPIEPVDPLLGIQSAVLRKSSHEQ NGPSYNESECLPVYEAIKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPA QLHLLEIKKTVINGQIVYEKS*" /label="ytcJ CDS" gene complement(2444428..2446017) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /label="ytcJ gene" downshifts complement(2444437) /Source="Nicolas_upshifts" /id="D1516" /incds=0 /nref=149 /ntot=255 /MaxReadThrough="2.61299" /MaxDrop="5.92403" /score="32.0110789" /energy="-13.8" /TU="NA" /idTUdmin="U2285" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2446037..2447626) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /EC_number="6.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-coenzyme A synthetase" /protein_id="NP_390834.2" /db_xref="EnsemblGenomes-Gn:BSU29560" /db_xref="EnsemblGenomes-Tr:CAB14934" /db_xref="GOA:C0SPB0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13834" /db_xref="UniProtKB/Swiss-Prot:C0SPB0" /translation="MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWS YEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLR AKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGS QFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWAT AAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMA KVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDT PIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQI RGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVA SPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTAS AKIRRVELRKREEQLKANKKA*" /label="ytcI CDS" gene complement(2446037..2447626) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /label="ytcI gene" promotor_-10 complement(2447672..2447689) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2447677) /Source="Nicolas_upshifts" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2447705..2447711) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2447804) /Source="Nicolas_upshifts" /id="D1517" /incds=0 /nref=242 /ntot=266 /MaxReadThrough="2.32229" /MaxDrop="9.17935" /score="30.5720337" /energy="-13.3" /TU="NA" /idTUdmin="U2287" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2447805..2448014) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2456528, 2468649, 3009398, 16707666" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2456528, 2468649, 3009398, 16707666; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha-type SASP)" /protein_id="NP_390835.1" /db_xref="EnsemblGenomes-Gn:BSU29570" /db_xref="EnsemblGenomes-Tr:CAB14935" /db_xref="GOA:P04831" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10786" /db_xref="UniProtKB/Swiss-Prot:P04831" /translation="MANNNSGNSNNLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRA NGSVGGEITKRLVSFAQQNMGGGQF*" /label="sspA CDS" gene complement(2447805..2448014) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /label="sspA gene" promotor_-35 2448010..2448014 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2448014 /Source="Nicolas_upshifts" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2448023..2448037 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2448035..2448046) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2448046) /Source="Nicolas_upshifts" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2448061..2448067) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2448108..2449313) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /EC_number="2.8.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14757766, 16343540, 22773787, 24705700, 28287455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14757766, 16343540, 22773787, 24705700, 28287455; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="persulfide ATP pyrophosphatase involved in tRNA modification" /protein_id="NP_390836.2" /db_xref="EnsemblGenomes-Gn:BSU29580" /db_xref="EnsemblGenomes-Tr:CAB14936" /db_xref="GOA:O34595" /db_xref="InterPro:IPR003720" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020536" /db_xref="SubtiList:BG13827" /db_xref="UniProtKB/Swiss-Prot:O34595" /translation="MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYF SNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKP GDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATF LTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSER AKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIR EKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTY ETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQE ANDKFAELF*" /label="trmG CDS" gene complement(2448108..2449313) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /label="trmG gene" CDS complement(2449317..2450462) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_390837.1" /db_xref="EnsemblGenomes-Gn:BSU29590" /db_xref="EnsemblGenomes-Tr:CAB14937" /db_xref="GOA:O34874" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="SubtiList:BG12632" /db_xref="UniProtKB/Swiss-Prot:O34874" /translation="MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQL LQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVT ESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEA AGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGT RLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLS EIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKV LLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR*" /label="iscSB CDS" gene complement(2449317..2450462) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /label="iscSB gene" S_feature complement(2450463..2451606) /Source="Nicolas_S_feature" /locus_tag="new_3028103_3029246_c" /HighExp="Diami, dia15, dia5, H2O2, G135, G180, G150, C30, Paraq, LBGstat" /AntisenseName="braB" /AntisenseCor="0.41502288403214899" /AntisenseRegPval="-11.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1123" promotor_-35 2450549..2450556 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2450567..2450656 /Source="Nicolas_S_feature" /locus_tag="new_3028207_3028296" /HighExp="LPh, HPh, BMM, dia0, Heat, G180, Cold, LBGexp, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1124" upshifts 2450567 /Source="Nicolas_upshifts" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2450569..2450588 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2450657..2451994 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11528000, 15849754, 16850406, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11528000, 15849754, 16850406, 26473603; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid-Na+ symporter" /protein_id="NP_390838.1" /db_xref="EnsemblGenomes-Gn:BSU29600" /db_xref="EnsemblGenomes-Tr:CAB14938" /db_xref="GOA:O34545" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG12573" /db_xref="UniProtKB/Swiss-Prot:O34545" /translation="MKHSLPVKDTIIIGFMLFALFFGAGNMIYPPELGQAAGHNVWKA IGGFLLTGVGLPLLGIIAIALTGKDAKGLADKAHPVFGTIFTVVLYLSIGPLFAIPRT GTVSYEIGAVPFLTGVPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTI ILIIVLKAIFTPMGGLGAVTEAYKGTPVFKGFLEGYKTMDALASIVFGVVVVNAVKSK GVTQSKALAAACIKAGVIAALGLTFIYVSLAYLGATSTNAIGPVGEGAKILSASSHYL FGSLGNIVLGAAITVACLTTSIGLVTSCGQYFSKLIPALSYKIVVTIVTLFSLIIANF GLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSILDGIKA AGFSLGSLDVFLNANLPLYSLGIGWVLPGIVGAVIGYVLTLFIGPSKQLNEIS*" /label="braB CDS" gene 2450657..2451994 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /label="braB gene" promotor_-10 complement(2451592..2451611) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2451606) /Source="Nicolas_upshifts" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2451626..2451633) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2451970 /Source="Nicolas_upshifts" /id="D1518" /incds=0 /nref=69 /ntot=174 /MaxReadThrough="1.86149" /MaxDrop="6.26921" /score="14.5905051" /energy="-15.2" /TU="U2288" /idTUdmin="U2288" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2452089..2453777) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of FtsZ ring formation" /protein_id="NP_390839.1" /db_xref="EnsemblGenomes-Gn:BSU29610" /db_xref="EnsemblGenomes-Tr:CAB14939" /db_xref="GOA:O34894" /db_xref="InterPro:IPR010379" /db_xref="PDB:4UXV" /db_xref="SubtiList:BG13934" /db_xref="UniProtKB/Swiss-Prot:O34894" /translation="MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSI VEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKAN QVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKL LADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDI DEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETEL VKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIE EVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLE NAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFG NRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA*" /label="ezrA CDS" gene complement(2452089..2453777) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /label="ezrA gene" downshifts complement(2452090) /Source="Nicolas_upshifts" /id="D1519" /incds=0 /nref=224 /ntot=257 /MaxReadThrough="3.34218" /MaxDrop="5.3305" /score="9.25784495" /energy="-8.6" /TU="U2290" /idTUdmin="U2290" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2453778..2453883) /Source="Nicolas_S_feature" /locus_tag="new_3031418_3031523_c" /HighExp="C90, Lbtran, BMM, LBGtran, MG 150, S1, Lbexp, dia0, LBGexp, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1125" promotor_-35 2453860..2453868 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2453871..2453890) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2453879..2453898 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2453883) /Source="Nicolas_upshifts" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" upshifts 2453883 /Source="Nicolas_upshifts" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2453884..2453973 /Source="Nicolas_S_feature" /locus_tag="new_3031524_3031613" /HighExp="HiOs, C90, dia5, T-5.40H, S1, T-3.40H, GM-0.1, GM 15, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1126" S_feature complement(2453885..2454444) /Source="Nicolas_S_feature" /locus_tag="new_3031525_3032084_c" /HighExp="Etha, Salt, Cold, G135, Lbstat, G180, G150, H2O2, Heat, Paraq" /AntisenseName="hisJ" /AntisenseCor="0.37018688255337001" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1127" promotor_-35 complement(2453906..2453908) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2453974..2454780 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /EC_number="3.1.3.15" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10322033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol phosphate phosphatase" /protein_id="NP_390840.1" /db_xref="EnsemblGenomes-Gn:BSU29620" /db_xref="EnsemblGenomes-Tr:CAB14940" /db_xref="GOA:O34411" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010140" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG13931" /db_xref="UniProtKB/Swiss-Prot:O34411" /translation="MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPL PPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITL FLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYS SIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTS GLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC*" /label="hisK CDS" gene 2453974..2454780 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /label="hisK gene" promotor_-10 complement(2454448..2454467) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2454461) /Source="Nicolas_upshifts" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2454479..2454486) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2454730..2454776) /Source="Nicolas_S_feature" /locus_tag="new_3032370_3032416_c" /HighExp="M9-stat, T5.0H, LoTm, T4.0H, S2, BC, T3.30H, S4, T3.0H, B60" /AntisenseName="hisJ" /AntisenseCor="-0.46006853678527698" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1128" downshifts complement(2454752) /Source="Nicolas_upshifts" /id="D1520" /incds=0 /nref=51 /ntot=97 /MaxReadThrough="1.55523" /MaxDrop="6.84653" /score="-4.34170655" /energy="-10.5" /TU="NA" /idTUdmin="U2296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2454777..2455400) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11988534, 22730127, 26360512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 22730127, 26360512; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of FtsZ defining the chromosome regioncaptured in the forespore" /protein_id="NP_390841.1" /db_xref="EnsemblGenomes-Gn:BSU29630" /db_xref="EnsemblGenomes-Tr:CAB14941" /db_xref="GOA:O34970" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG13927" /db_xref="UniProtKB/Swiss-Prot:O34970" /translation="MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHISYY FKGKGGLMEHLVSEFYEGYSKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTR FVYREVTIDSTLIREIMSTYLMKEKYIFQLIIEEGEKQREYLTLPLPHFILQLKSLLM MPYLQPQYISEVLYMQPHEPYFYKMYFEEIKIWIRSVFRTGDVALTN*" /label="refZ CDS" gene complement(2454777..2455400) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /label="refZ gene" S_feature 2454781..2455123 /Source="Nicolas_S_feature" /locus_tag="new_3032421_3032763" /HighExp="C90, HiOs, Sw, dia5, GM-0.1, S1, MG 5, UNK1, MG 60, MG t5" /AntisenseName="yttP" /AntisenseCor="-0.79169109805002003" /AntisenseRegPval="-58.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1129" promotor_-35 2455101..2455108 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2455123..2455142 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2455125..2455268 /Source="Nicolas_S_feature" /locus_tag="new_3032765_3032908" /HighExp="Diami, dia15, dia5, H2O2, C90, Paraq, Salt, Etha, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.81457903975257295" /AntisenseRegPval="-64.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1130" upshifts 2455125 /Source="Nicolas_upshifts" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2455240..2455244 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2455260..2455279 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2455270..2455400 /Source="Nicolas_S_feature" /locus_tag="new_3032910_3033040" /HighExp="Diami, dia15, dia5, H2O2, Paraq, C90, HPh, LBGexp, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.82273476313537297" /AntisenseRegPval="-66.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1131" upshifts 2455270 /Source="Nicolas_upshifts" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2455402..2455526 /Source="Nicolas_S_feature" /locus_tag="new_3033042_3033166" /HighExp="Diami, dia5, dia15, H2O2, C90, BC, HiOs, Paraq, Sw, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.598, 0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1132" upshifts 2455402 /Source="Nicolas_upshifts" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2455416..2455434) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2455418..2455437 /Source="Nicolas_upshift_promotors" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2455434) /Source="Nicolas_upshifts" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2455445..2455453) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2455527..2456018 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /EC_number="1.8.4.14" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17535911, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="free methionine-(R)-sulfoxide reductase" /protein_id="NP_390842.2" /db_xref="EnsemblGenomes-Gn:BSU29640" /db_xref="EnsemblGenomes-Tr:CAB14942" /db_xref="InterPro:IPR000614" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG13923" /db_xref="UniProtKB/Swiss-Prot:O34553" /translation="MFHVEKQSGDKEKDYQLLLKQLEAMTEDETDQIANYANASALLY HSLPEVNWAGFYFAKEEDGQLVLGPFQGLPACVRIPFGRGVCGTAYANGKVERIEDVN AFPGHIACDAASQSEIVLPIRVDGKIVGVLDIDSPVKNRFDEIDEKYLTQFAETLEKA LAQ*" /label="msrC CDS" gene 2455527..2456018 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /label="msrC gene" downshifts 2455997 /Source="Nicolas_upshifts" /id="D1521" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="3.66093" /MaxDrop="6.50628" /score="34.0123402" /energy="-11.9" /TU="U2291,U2293,U2294" /idTUdmin="U2295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2456056..2457795) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /EC_number="2.7.7.65" /function="16.12: Sense" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_390843.1" /db_xref="EnsemblGenomes-Gn:BSU29650" /db_xref="EnsemblGenomes-Tr:CAB14943" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG13918" /db_xref="UniProtKB/Swiss-Prot:O34325" /translation="MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYF STLCVSLTPSPSDFVTKLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEG LPDVVASFLNQSMKQERLYNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSL FEFSLFISHDQDQCLGIPAKELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQ GTYGVLKAEGTGDSFLTDACLDEMSLLANAAGKAFENAQLYEQSKASIANLELINETS RRLNQRLTLTDTMNDLAVRMAESFQAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDF YNELKEKLYEGEKGVFIGNGQSVFGKAGYGSLMAAPMIQNDRLLGFAVLLKQELYAFT FEMYKLFQALIHHATLAVTNSMLRDRLEHLVKTDQLTELYSRAYLDEKIQYSMKIHQK GVFILVDIDNFKNVNDTYGHQTGDEILIQVASVIKSNIRKHDVGARWGGEELAIYLPN VPVAVGKRITERLVYAVRKNTKPEVTISCGISCWTTETKKSLKELVHEADEALYSAKR SGKNRLMIHDSIK*" /label="dgcP CDS" gene complement(2456056..2457795) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /label="dgcP gene" downshifts complement(2456074) /Source="Nicolas_upshifts" /id="D1522" /incds=0 /nref=23 /ntot=178 /MaxReadThrough="3.68958" /MaxDrop="4.52201" /score="-0.637788006" /energy="-11.9" /TU="U2298" /idTUdmin="U2298" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" promotor_-35 2457269..2457276 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-35" promotor_-10 2457290..2457308 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-10" upshifts 2457293 /Source="Nicolas_upshifts" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="upshifts" S_feature 2457295..2457890 /Source="Nicolas_S_feature" /locus_tag="new_3034935_3035530" /HighExp="Cold, LBGstat, C30, Lbstat, GM 25, GM 10, GM 120, GM-0.1, GM 5, GM-0.2" /AntisenseName="ytrP" /AntisenseCor="-0.113221814489707" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1133" misc_feature complement(2457825..2457844) /Source="Nicolas_upshift_promotors" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2457833) /Source="Nicolas_upshifts" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2457835..2458668) /Source="Nicolas_S_feature" /locus_tag="new_3035475_3036308_c" /HighExp="Etha, S7, Gly, S8, M9-stat, Sw, G135, S6, BC, C30" /AntisenseName="rpsD" /AntisenseCor="-0.48019282175486899" /AntisenseRegPval="-16.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1134" promotor_-35 2457871..2457878 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2457892..2458089 /Source="Nicolas_S_feature" /locus_tag="new_3035532_3035729" /HighExp="UNK1, Cold, HPh, C30, aero, LPhT, MG 25, Oxctl, Heat, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.139124" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1135" promotor_-10 2457892..2457911 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2457892 /Source="Nicolas_upshifts" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2457949..2458081 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /product="ribosomal protein S4 leader mRNA sequence" /experiment="publication(s) with functional evidences, PMID:23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23611891" /label="ldsD RNA" gene 2457949..2458081 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /label="ldsD gene" CDS 2458090..2458692 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1400226, 1699930, 1906866, 12682299, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400226, 1699930, 1906866, 12682299, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S4 (BS4)" /protein_id="NP_390844.1" /db_xref="EnsemblGenomes-Gn:BSU29660" /db_xref="EnsemblGenomes-Tr:CAB14944" /db_xref="GOA:P21466" /db_xref="InterPro:IPR001912" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR005709" /db_xref="InterPro:IPR018079" /db_xref="InterPro:IPR022801" /db_xref="InterPro:IPR036986" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10372" /db_xref="UniProtKB/Swiss-Prot:P21466" /translation="MARYTGPSWKLSRRLGISLSGTGKELEKRPYAPGPHGPGQRKKL SEYGLQLQEKQKLRHMYGVNERQFRTLFDKAGKLAGKHGENFMILLDSRLDNVVYKLG LARTRRQARQLVNHGHILVDGSRVDIPSYLVKPGQTIGVREKSRNLSIIKESVEVNNF VPEYLTFDAEKLEGTFTRLPERSELAPEINEALIVEFYSR*" /label="rpsD CDS" gene 2458090..2458692 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /label="rpsD gene" downshifts 2458615 /Source="Nicolas_upshifts" /id="D1523" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="8.1141" /MaxDrop="2.9392" /score="31.6842" /energy="-13.6" /TU="U2297,U2299" /idTUdmin="U2297" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(2458670..2458889) /Source="Nicolas_S_feature" /locus_tag="new_3036310_3036529_c" /HighExp="S5, Etha, S8, S6, S7, S4, BT, S3, M9-stat, B36" /AntisenseName="rpsD" /AntisenseCor="-0.59018291599064199" /AntisenseRegPval="-25.9" /CDS_PredictionProba="0.99997899999999995" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1136" downshifts 2458678 /Source="Nicolas_upshifts" /id="D1524" /incds=0 /nref=135 /ntot=252 /MaxReadThrough="5.6866" /MaxDrop="6.10502" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=19 /isTUend="TRUE" /label="downshifts" downshifts complement(2458713) /Source="Nicolas_upshifts" /id="D1525" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="4.84346" /MaxDrop="3.28594" /score="-4.07107651" /energy="-10.8" /TU="U2300" /idTUdmin="U2301" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2458725 /Source="Nicolas_upshifts" /id="D1526" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="5.7799" /MaxDrop="4.26349" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2458770..2458943 /Source="Nicolas_S_feature" /locus_tag="new_3036410_3036583" /HighExp="LBGtran, LoTm, C30, Cold, LBGexp, B60, dia15, B36, H2O2, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig=1 /label="S1137" promotor_-10 complement(2458885..2458903) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2458897) /Source="Nicolas_upshifts" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="upshifts" downshifts 2458901 /Source="Nicolas_upshifts" /id="D1527" /incds=0 /nref=7 /ntot=151 /MaxReadThrough="1.39547" /MaxDrop="6.12149" /score="26.4940291" /energy="-16.4" /TU="NA" /idTUdmin="U2299" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2458918..2458924) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2458963..2460231) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /EC_number="6.1.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12547201, 15879350, 1735721, 9098057" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12547201, 15879350, 1735721, 9098057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_390845.1" /db_xref="EnsemblGenomes-Gn:BSU29670" /db_xref="EnsemblGenomes-Tr:CAB14945" /db_xref="GOA:P22326" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024107" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10371" /db_xref="UniProtKB/Swiss-Prot:P22326" /translation="MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADS LHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTADIVSEWSQKI KNQLSRFLDFEAAENPAVIANNFDWIGKMNVIDFLRDVGKNFGINYMLAKDTVSSRIE SGISYTEFSYMILQSYDFLNLYRDKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAF GLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLS KEEIEAYAEKTETAPEKREAQKRLAEEVTSLVHGREALEQAINISQALFSGNIKELSA QDVKVGFKDVPSMEVDSTQELSLVDVLVQSKLSPSKRQAREDIQNGAVYINGERQTEI NYTLSGEDRIENQFTVLRRGKKKYFLVTYK*" /label="tyrS CDS" gene complement(2458963..2460231) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /label="tyrS gene" downshifts complement(2458989) /Source="Nicolas_upshifts" /id="D1528" /incds=0 /nref=110 /ntot=357 /MaxReadThrough="2.2673" /MaxDrop="6.847" /score="22.5238672" /energy="-16.4" /TU="NA" /idTUdmin="U2301" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" misc_RNA complement(2460255..2460528) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /product="T-Box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 10943892, 1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 10943892, 1317842, 9098041, 12165569, 12547201; Product type n : RNA" /function="16.3: Control" /label="tboY RNA" gene complement(2460255..2460528) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /label="tboY gene" S_feature complement(2460276..2460419) /Source="Nicolas_S_feature" /locus_tag="new_3037916_3038059_c" /HighExp="B60, Sw, B36, BC, M9-stat, T1.30H, S4, T4.0H, T2.30H, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40126600000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1138" downshifts complement(2460319) /Source="Nicolas_upshifts" /id="D1529" /incds=0 /nref=58 /ntot=127 /MaxReadThrough="6.75235" /MaxDrop="6.49727" /score="45.7279775" /energy="-17.7" /TU="U2301,U2303" /idTUdmin="U2301" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2460526..2460545) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2460538) /Source="Nicolas_upshifts" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2460558..2460565) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2460573..2462291) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /EC_number="6.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7934817, 10986270, 11255012, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10986270, 11255012, 16855235, 18487328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA synthetase" /protein_id="NP_390846.1" /db_xref="EnsemblGenomes-Gn:BSU29680" /db_xref="EnsemblGenomes-Tr:CAB14946" /db_xref="GOA:P39062" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG10370" /db_xref="UniProtKB/Swiss-Prot:P39062" /translation="MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNA AYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRV FIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERI PVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGST GTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATN VIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGE PLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVD NQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYF WFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREG FEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGD LSTMED*" /label="acsA CDS" gene complement(2460573..2462291) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /label="acsA gene" promotor_-35 2462305..2462312 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2462319..2462338) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2462327..2462346 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2462333 /Source="Nicolas_upshifts" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2462342) /Source="Nicolas_upshifts" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2462352..2462358) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2462375..2462382 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2462396..2462415 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2462399 /Source="Nicolas_upshifts" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2462452..2463084 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein acetyltransferase (acetylates AcsA)" /protein_id="NP_390847.1" /db_xref="EnsemblGenomes-Gn:BSU29690" /db_xref="EnsemblGenomes-Tr:CAB14947" /db_xref="GOA:P39065" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR024699" /db_xref="SubtiList:BG10369" /db_xref="UniProtKB/Swiss-Prot:P39065" /translation="MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRP PREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIE VAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMM NAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY*" /label="acuA CDS" gene 2462452..2463084 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /label="acuA gene" promotor_-35 2462657..2462665 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2462679..2462698 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2462685 /Source="Nicolas_upshifts" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2463111..2463755 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type f : factor" /codon_start=1 /transl_table=11 /product="component of the acetyl-coenzyme A synthetase regulation pathway" /protein_id="NP_390848.1" /db_xref="EnsemblGenomes-Gn:BSU29700" /db_xref="EnsemblGenomes-Tr:CAB14948" /db_xref="GOA:P39066" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG10368" /db_xref="UniProtKB/Swiss-Prot:P39066" /translation="MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHV IGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHG IGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQD LQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL*" /label="acuB CDS" gene 2463111..2463755 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /label="acuB gene" CDS 2463752..2464915 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein deacetylase (regulates AcsA activity)" /protein_id="NP_390849.1" /db_xref="EnsemblGenomes-Gn:BSU29710" /db_xref="EnsemblGenomes-Tr:CAB14949" /db_xref="GOA:P39067" /db_xref="InterPro:IPR000286" /db_xref="InterPro:IPR003085" /db_xref="InterPro:IPR023696" /db_xref="InterPro:IPR023801" /db_xref="InterPro:IPR037138" /db_xref="SubtiList:BG10367" /db_xref="UniProtKB/Swiss-Prot:P39067" /translation="MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDG DIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAA SLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYS ARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSF NIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYE EIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIV KWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK*" /label="acuC CDS" gene 2463752..2464915 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /label="acuC gene" downshifts 2464906 /Source="Nicolas_upshifts" /id="D1530" /incds=0 /nref=98 /ntot=231 /MaxReadThrough="0.530530000000001" /MaxDrop="6.5095" /score="10.9528437" /energy="-9.1" /TU="NA" /idTUdmin="U2304" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2464926..2465654) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation" /protein_id="NP_390850.1" /db_xref="EnsemblGenomes-Gn:BSU29720" /db_xref="EnsemblGenomes-Tr:CAB14950" /db_xref="GOA:P39064" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10366" /db_xref="UniProtKB/Swiss-Prot:P39064" /translation="MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFS MSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYI KDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQ VEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDN KTNEHMKENRRVEIVIKKSKTTSS*" /label="motS CDS" gene complement(2464926..2465654) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /label="motS gene" downshifts complement(2464962) /Source="Nicolas_upshifts" /id="D1531" /incds=0 /nref=37 /ntot=149 /MaxReadThrough="1.3853" /MaxDrop="3.98206" /score="4.77211813" /energy="-6.9" /TU="NA" /idTUdmin="U2307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2465644..2466462) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator subunit offlagellar rotation" /protein_id="NP_390851.1" /db_xref="EnsemblGenomes-Gn:BSU29730" /db_xref="EnsemblGenomes-Tr:CAB14951" /db_xref="GOA:P39063" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10365" /db_xref="UniProtKB/Swiss-Prot:P39063" /translation="MKRFDYLTPVGFVLGTIIIVIGIISGSGVSGFRSFLDLTSFFIV TGGLCAAVFISFPPSELKKAPSVLKQAFIRQEDNVKDLVKTFVSLSDHARKHGLLSLD DQAREIKDPFLKKGLLLAIDGWDEETIRLVMDSEIAAMEERHRKGRRVFEKAGEFAPA WGMIGTLVGLVLMLKNLNDPHMLGPNMAIALLTTLYGSLLANMVFNPIAAKLEEKTES EIFIKQVMVEGIIGVQSGKNPRNLESQLVVFSSREEWQKQPKQVKTKKGSVHEA*" /label="motP CDS" gene complement(2465644..2466462) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /label="motP gene" CDS complement(2466525..2467529) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catabolite repression (Lacl family)" /protein_id="NP_390852.1" /db_xref="EnsemblGenomes-Gn:BSU29740" /db_xref="EnsemblGenomes-Tr:CAB14952" /db_xref="GOA:P25144" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR006377" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="PDB:1ZVV" /db_xref="PDB:2FEP" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10376" /db_xref="UniProtKB/Swiss-Prot:P25144" /translation="MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIER LGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQN MEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAI DYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVA EGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFD NTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS *" /label="ccpA CDS" gene complement(2466525..2467529) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /label="ccpA gene" downshifts complement(2466542) /Source="Nicolas_upshifts" /id="D1532" /incds=0 /nref=62 /ntot=239 /MaxReadThrough="4.60553" /MaxDrop="4.6531" /score="5.3377823" /energy="-13.2" /TU="U2307,U2308,U2309" /idTUdmin="U2306" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(2467564..2467583) /Source="Nicolas_upshift_promotors" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2467579) /Source="Nicolas_upshifts" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2467581..2467689) /Source="Nicolas_S_feature" /locus_tag="new_3045221_3045329_c" /HighExp="Oxctl, H2O2, Paraq, MG-0.1, MG-0.2, G150, GM 15, Diami, LBGexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigB" /TUshortPSig="0.988, 1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1139" promotor_-10 complement(2467689..2467708) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2467689) /Source="Nicolas_upshifts" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2467691..2467756) /Source="Nicolas_S_feature" /locus_tag="new_3045331_3045396_c" /HighExp="BMM, GM 120, Diami, GM 90, M/G, GM 25, M9-exp, HiTm, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1140" promotor_-35 complement(2467722..2467728) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2467802) /Source="Nicolas_upshifts" /id="D1533" /incds=0 /nref=66 /ntot=188 /MaxReadThrough="6.10221" /MaxDrop="6.29667" /score="46.0872381" /energy="-11.3" /TU="U2308,U2309,U2310" /idTUdmin="U2311" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2467805..2468881) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /EC_number="2.5.1.54" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4200844, 7496534, 11444986, 16339761, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4200844, 7496534, 11444986, 16339761, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional chorismate mutase type II-isozyme 3(regulatory domain); 3-deoxy-D-arabino-heptulosonate7-phosphate synthase" /protein_id="NP_390853.1" /db_xref="EnsemblGenomes-Gn:BSU29750" /db_xref="EnsemblGenomes-Tr:CAB14953" /db_xref="GOA:P39912" /db_xref="InterPro:IPR002701" /db_xref="InterPro:IPR006218" /db_xref="InterPro:IPR006268" /db_xref="InterPro:IPR010954" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036979" /db_xref="PDB:5GMU" /db_xref="PDB:5GO2" /db_xref="SubtiList:BG10375" /db_xref="UniProtKB/Swiss-Prot:P39912" /translation="MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVN RFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKP EDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSP YDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELL KAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDI SAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDS AQQMAIPEFEKWLNELKPMVKVNA*" /label="aroX CDS" gene complement(2467805..2468881) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /label="aroX gene" promotor_-10 complement(2468922..2468941) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-10" upshifts complement(2468942) /Source="Nicolas_upshifts" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="upshifts" S_feature complement(2468944..2469044) /Source="Nicolas_S_feature" /locus_tag="new_3046584_3046684_c" /HighExp="Lbtran, BMM, dia5, GM 25, GM 90, M9-exp, MG 150, Diami, MG-0.2, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigH" /TUshortPSig="0.974, 1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1141" promotor_-35 complement(2468956..2468963) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-35" downshifts 2468978 /Source="Nicolas_upshifts" /id="D1534" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.07872" /MaxDrop="3.23284" /score="1.10447256" /energy="-7.6" /TU="NA" /idTUdmin="U2304" /TUdmin=4071 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2469032..2469051) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2469044) /Source="Nicolas_upshifts" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2469065..2469071) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2469117..2469443) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22938038, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22938038, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin involved in debacillithiolation" /protein_id="NP_390854.1" /db_xref="EnsemblGenomes-Gn:BSU29760" /db_xref="EnsemblGenomes-Tr:CAB14954" /db_xref="InterPro:IPR022551" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10373" /db_xref="UniProtKB/Swiss-Prot:P39914" /translation="MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAF ANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAA IEQHLS*" /label="brxJ CDS" gene complement(2469117..2469443) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /label="brxJ gene" downshifts complement(2469126) /Source="Nicolas_upshifts" /id="D1535" /incds=0 /nref=144 /ntot=286 /MaxReadThrough="7.09736" /MaxDrop="5.96753" /score="13.8032115" /energy="-7.6" /TU="U2310,U2311" /idTUdmin="U2313" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2469467..2469922) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8733232, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390855.2" /db_xref="EnsemblGenomes-Gn:BSU29770" /db_xref="EnsemblGenomes-Tr:CAB14955" /db_xref="InterPro:IPR024623" /db_xref="SubtiList:BG10975" /db_xref="UniProtKB/Swiss-Prot:P40780" /translation="MSKDGINSKDFLIGTLIGGIIGATTALFLAPKSGKELRDDLGSQ AVALRDKTDKMTADAKEKGTQYVSIAKDKTSNITQLVADQSGQIMNKVKDLRDRSKSD KTDSSTAMQDMREEAMQAADETKDQVLQTKEDVKDELKDAQKQAEQLNR*" /label="ytxH CDS" gene complement(2469467..2469922) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /label="ytxH gene" CDS complement(2469953..2470375) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22720735, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein" /protein_id="NP_390856.2" /db_xref="EnsemblGenomes-Gn:BSU29780" /db_xref="EnsemblGenomes-Tr:CAB14956" /db_xref="GOA:P40779" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG10974" /db_xref="UniProtKB/Swiss-Prot:P40779" /translation="MIIILYLSVALIAVAFLVLVIYLSKTLKSLQLTLKNVASTLEGL EGQMKGITTETAELLHKTNRLAEDIQEKSEKLNTVVHAVQGVGASVQQFNTSMKQAAG SVSASVRENQDKINQVVTWSQAAMEIWEKWKQKKKSAL*" /label="ytxG CDS" gene complement(2469953..2470375) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /label="ytxG gene" promotor_-10 complement(2470396..2470414) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2470409) /Source="Nicolas_upshifts" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2470428..2470434) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2470448..2470466) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-10" upshifts complement(2470457) /Source="Nicolas_upshifts" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="upshifts" promotor_-35 complement(2470477..2470485) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-35" CDS complement(2470537..2471835) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /EC_number="6.3.2.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10565540, 12682299, 12781748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetyl muramate-alanine ligase" /protein_id="NP_390857.1" /db_xref="EnsemblGenomes-Gn:BSU29790" /db_xref="EnsemblGenomes-Tr:CAB14957" /db_xref="GOA:P40778" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005758" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10973" /db_xref="UniProtKB/Swiss-Prot:P40778" /translation="MTVYHFVGIKGTGMSPLAQILHDNGYTVQGSDIEKFIFTQTALE KRNITILPFSAENIKPGMTVIAGNAFPDTHPEIEKAMSEGIPVIRYHKFLGDYMKKFT SVAVTGAHGKTSTTGLLAHVIQNAKPTSFLIGDGTGQGNENSEYFVFEACEYRRHFLS YQPDYAIMTNIDFDHPDYFSSIDDVFDAFQEMALQVNKGIIACGDDEHLPKIHANVPV VYYGTGEENDFQARNIVKSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCH YEEIDSSIIKHALKSFGGVKRRFNEKQLGDQVLIDDYAHHPTEIKVTIEAARQKYPDR EIVAVFQPHTFTRTQQFLDEFAESLSGADCVYLCDIFGSARENAGKLTIGDLQGKIHN AKLIEEDDTSVLKAHDKAVLIFMGAGDIQKYMRAYENVMA*" /label="murC CDS" gene complement(2470537..2471835) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /label="murC gene" downshifts complement(2470546) /Source="Nicolas_upshifts" /id="D1536" /incds=0 /nref=29 /ntot=180 /MaxReadThrough="5.23049" /MaxDrop="5.42617" /score="15.3729968" /energy="-7.5" /TU="U2313,U2314" /idTUdmin="U2312" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2471860..2471879) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2471861) /Source="Nicolas_upshifts" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2471863..2472059) /Source="Nicolas_S_feature" /locus_tag="new_3049503_3049699_c" /HighExp="Cold, G150, G135, dia15, G180, H2O2, C30, Oxctl, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.938" /label="S1142" promotor_-35 complement(2471892..2471901) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2472042..2472061) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2472059) /Source="Nicolas_upshifts" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2472073..2472079) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2472085..2474943) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /function="8.1: DNA replication, recombination, and repair" /experiment="publication(s) with functional evidences, PMID:3129532, 11134515, 11208805, 19788545, 28110333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3129532, 11134515, 11208805, 19788545, 28110333; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="DNA translocase" /protein_id="NP_390859.2" /db_xref="EnsemblGenomes-Gn:BSU29805" /db_xref="EnsemblGenomes-Tr:CAB14959" /db_xref="GOA:C0SP86" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13906" /db_xref="UniProtKB/Swiss-Prot:C0SP86" /translation="MSWLHKFFDLFLGESEEDAERETKPAQIPQQQEVHHPEGQLKRL EDPKIYYEYPKGKFRFPVVPDGYKNHDLRRRRTPSDEPKSAPRPSAAPYRERPRNEEE QHTYQAAEPAKKPFKPTNIPSPVYGFNQKPSVKKDVPKKPSETLNEPDKSVKEKVTLL SEEIERERGYPASDTQAHSKIESPFFPDTQFEKQPSGVLNRKDTEHDEALAKRPAEPS GNKVPFESGVQQPEKEEPFFPAEQAEEQTPPEMLTDTAAEGLSDSEVGREEPATAEEE QREQQPEKFEEPVFSAELDEEQTAPESQTEAVSEDEKAKEPSDSPVYNHHENAAEGAE SPFVQEEQMDIRQEEPLFTDHEYSSEALAQAETVAKESEEPSESIINNHYDTLGEAQE TKIDVQPDSHTELEKTEHMEQGSKSSTATLENRQEIRADKPREASEEPKKRPGVQEKR TEQSASSQKGPSVPFNVMMLKRDTHKQQKAEERRGSYVFPNVALLDVPPAQVQDDTAW IEEQRQLLDLTLKNFNVRANVVHVTQGPSVTRFEVHPEPGVKVNKITNLSDDIKLSLS AKDIRIEAPIPGKNTIGIEVPNRTSKVVDLRQMIRSSAFRTSKSPLTAALGLDISGNP VVIDLKKMPHGLIAGATGSGKSVCINTILVSLLYKADPSEVKVLLIDPKMVELAPYNK IPHLVSPVITDAKAATAALKWVVEEMERRYELFAHSGVRDIDRFNQLTAEHQMGEKLP YLVVIIDELADLMMVAPNDVEESIARIAQKARACGIHLLVATQRPSVDVITGLIKANI PTRIAFSVSSQVDSRTIIDIAGAEKLLGKGDMLFLENGSGKPVRLQGNFVSDREIDRV VSHVRSQMPPTYLFEQEELVRQGSALKEEDELFYEACEFVVEQNSASTSSLQRRFRIG YNRAARLIDMMEAEGMISEAKGSKPREVLITASDLINE*" /label="sftA CDS" gene complement(2472085..2474943) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /label="sftA gene" promotor_-10 complement(2474977..2474996) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-10" upshifts complement(2474987) /Source="Nicolas_upshifts" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="upshifts" promotor_-35 complement(2475012..2475016) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-35" downshifts complement(2475086) /Source="Nicolas_upshifts" /id="D1537" /incds=0 /nref=186 /ntot=249 /MaxReadThrough="4.47299" /MaxDrop="6.35097" /score="9.62039509" /energy="-14.5" /TU="U2315" /idTUdmin="U2315" /TUdmin="-1553" /isTUend="FALSE" /label="downshifts" CDS complement(2475103..2475708) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21949854, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA binding enzyme" /protein_id="NP_390860.1" /db_xref="EnsemblGenomes-Gn:BSU29820" /db_xref="EnsemblGenomes-Tr:CAB14960" /db_xref="GOA:O34943" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027855" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR037154" /db_xref="SubtiList:BG13905" /db_xref="UniProtKB/Swiss-Prot:O34943" /translation="MNAFYNKEGVGDTLLISLQDVTREQLGYEKHGDVVKIFNNETKE TTGFNIFNASSYLTIDENGPVALSETFVQDVNEILNRNGVEETLVVDLSPKFVVGYVE SKEKHPNADKLSVCKVNVGEETLQIVCGAPNVDQGQKVVVAKVGAVMPSGLVIKDAEL RGVPSSGMICSAKELDLPDAPAEKGILVLEGDYEAGDAFQF*" /label="ytpR CDS" gene complement(2475103..2475708) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /label="ytpR gene" CDS complement(2475724..2476533) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12719520, 21949854" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (iron homeostasis)" /protein_id="NP_390861.1" /db_xref="EnsemblGenomes-Gn:BSU29830" /db_xref="EnsemblGenomes-Tr:CAB14961" /db_xref="InterPro:IPR010838" /db_xref="SubtiList:BG13904" /db_xref="UniProtKB/Swiss-Prot:O34496" /translation="MKMTSRKLSDILKQRLQHENRSFLFDREKDTLRVEDQTTKKGIT LDLPPIIAKWELKKDEAIDEIVYYVSEAMTAMEGKAQEMTGKETRIYPVIRSTSFPDK SSEDIPLIYDDHTAETRIYYALDLGKTYRLIDQRMLEKENWTKERIRETAAFNLRSLP TVVKEDTVAGNYFYFFRANDGYDASRILNEAILNEYKQHAEGELAISVPHQDVLILAD IRNESGYDILGQMSMSFFAGGTVPITALSFLYNEGKLEPVFILAKSRPKKD*" /label="ytpQ CDS" gene complement(2475724..2476533) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /label="ytpQ gene" CDS complement(2476548..2476871) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12719520, 15937154, 21949854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_390862.1" /db_xref="EnsemblGenomes-Gn:BSU29840" /db_xref="EnsemblGenomes-Tr:CAB14962" /db_xref="GOA:O34357" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13903" /db_xref="UniProtKB/Swiss-Prot:O34357" /translation="MKKIESTQELEKAVKDDWSVFMFSADWCPDCRFVEPFLPELEAN FPEFTYYYVDRDKFIDTCAEWEIYGIPSFVVFNEGKEVNRFVSKDRKTKEEIEQFLTD SLAKA*" /label="ytpP CDS" gene complement(2476548..2476871) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /label="ytpP gene" S_feature complement(2476872..2477010) /Source="Nicolas_S_feature" /locus_tag="new_3054512_3054650_c" /HighExp="G180, G150, Paraq, Oxctl, H2O2, Diami, C90, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.32150299999999998" /TUshortSig="SigA" /TUshortPSig="0.938" /TUlongSig="NA" /TUlongPSig="NA" /label="S1143" CDS complement(2476910..2477026) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513998.1" /translation="MQIKYDNDNGKANLTYSFVAYKWFCLKQFGMIQMDEYR*" /label="hypothetical protein CDS" gene complement(2476910..2477026) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /label="gene" promotor_-10 complement(2476997..2477016) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-10" upshifts complement(2477010) /Source="Nicolas_upshifts" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="upshifts" promotor_-35 2477018..2477025 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2477040..2477059 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2477045 /Source="Nicolas_upshifts" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="upshifts" CDS 2477106..2477552 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with sugar binding fold" /protein_id="NP_390863.1" /db_xref="EnsemblGenomes-Gn:BSU29850" /db_xref="EnsemblGenomes-Tr:CAB14963" /db_xref="InterPro:IPR019884" /db_xref="SubtiList:BG13899" /db_xref="UniProtKB/Swiss-Prot:O34305" /translation="MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDN IGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAI AKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE*" /label="ytoQ CDS" gene 2477106..2477552 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /label="ytoQ gene" S_feature 2477553..2478281 /Source="Nicolas_S_feature" /locus_tag="new_3055193_3055921" /HighExp="H2O2, dia15, C30, C90, Diami, S1, M0t45, Salt, Paraq, Lbexp" /AntisenseName="ytoP" /AntisenseCor="0.35418735783791" /AntisenseRegPval="-8.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.981" /TUlongSig="NA" /TUlongPSig="NA" /label="S1144" CDS complement(2477607..2478680) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8535515; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative modified amino acid aminopeptidase" /protein_id="NP_390864.1" /db_xref="EnsemblGenomes-Gn:BSU29860" /db_xref="EnsemblGenomes-Tr:CAB14964" /db_xref="GOA:O34924" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13898" /db_xref="UniProtKB/Swiss-Prot:O34924" /translation="MNQETKALFQTLTQLPGAPGNEHQVRAFMKQELAKYADDIVQDR LGSVFGVRRGAEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTLGGWWSQVLLAQRVE IQTDNGPVPGVISSIPPHLLTDAQRNRPMDIKNMMIDIGADDKEDAIKIGIRPGQQIV PVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHGKELPNTLYAGATVQEEVGLRG AQTASHMIKPDLFFALDASPANDMSGDKNEFGQLGKGFLLRILDRTTVMHRGMREFVL DMAETHDIPYQYFVSGGGTDAGKVHISNSGVPSAVIGICSRYIHTNATIIHIDDYAAA KEMLIKLVTACDKQTVDAIKENM*" /label="ytoP CDS" gene complement(2477607..2478680) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /label="ytoP gene" downshifts complement(2477626) /Source="Nicolas_upshifts" /id="D1538" /incds=0 /nref=140 /ntot=248 /MaxReadThrough="1.89952" /MaxDrop="4.55096" /score="14.9571314" /energy="-14.4" /TU="NA" /idTUdmin="U2317" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2478702..2478721) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2478706) /Source="Nicolas_upshifts" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2478735..2478742) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2478777..2478780 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2478795..2478814 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2478800 /Source="Nicolas_upshifts" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="upshifts" CDS 2478839..2479156 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390865.1" /db_xref="EnsemblGenomes-Gn:BSU29870" /db_xref="EnsemblGenomes-Tr:CAB14965" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13936" /db_xref="UniProtKB/Swiss-Prot:O32065" /translation="MKLRHLLLGAGLGICTAVVVRQYVMKPYISSEKALRIVKSAFKQ RGPIDGSWIYTQPEPYNINGETVQVYKTGITRSAFGELEQYEVMVDAKTGEIVDVIDT IAS*" /label="ytzB CDS" gene 2478839..2479156 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /label="ytzB gene" downshifts 2479156 /Source="Nicolas_upshifts" /id="D1539" /incds=0 /nref=250 /ntot=259 /MaxReadThrough="1.29231" /MaxDrop="7.83082" /score="44.9062865" /energy="-17" /TU="NA" /idTUdmin="U2318" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2479209..2480909) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 20933603, 22740702, 23136871, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_390866.1" /db_xref="EnsemblGenomes-Gn:BSU29880" /db_xref="EnsemblGenomes-Tr:CAB14966" /db_xref="GOA:O34389" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG12614" /db_xref="UniProtKB/Swiss-Prot:O34389" /translation="MKQFRVTNEGDIQTTLRGLEVLSVPFLNKGVAFTEEERKELGLK GFLPPKVLTIDDQAKRAYEQYSAQPDDLSKNVYLTALHDRNETLFYRLLNDHLGEMLP IVYTPTVGTAIQRYSHEYRKPRGLYLSIDDPDGMKEAFKQYKDQSDTIDLIVATDAEG ILGIGDWGVGGIAISIGKLAVYTAAAGIDPSRVLAVVLDAGTNQESLLNDPLYVGNQH SRVRGERYDQFIDDYVALARETFPNALLHWEDFGAKNARSILKRYKDKVCTFNDDIQG TGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKR FWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILI GTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSP FPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVP GAPMLPKVEDLRTVSATVAVEVAKTAMKEGVATEEPEDIIQAVQDAMWYPVYKPIRAI *" /label="maeC CDS" gene complement(2479209..2480909) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /label="maeC gene" downshifts complement(2479228) /Source="Nicolas_upshifts" /id="D1540" /incds=0 /nref=77 /ntot=255 /MaxReadThrough="2.4872" /MaxDrop="4.99085" /score="17.675308" /energy="-15.3" /TU="NA" /idTUdmin="U2319" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2480941..2480959) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2480948) /Source="Nicolas_upshifts" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2480974..2480980) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2480991..2481761) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22101040, 24268182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative quorum-quenching lactonase" /protein_id="NP_390867.1" /db_xref="EnsemblGenomes-Gn:BSU29890" /db_xref="EnsemblGenomes-Tr:CAB14967" /db_xref="GOA:O34760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13895" /db_xref="UniProtKB/Swiss-Prot:O34760" /translation="MFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGI GYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGER LVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITM HHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQ AFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR*" /label="ytnP CDS" gene complement(2480991..2481761) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /label="ytnP gene" S_feature complement(2481762..2481850) /Source="Nicolas_S_feature" /locus_tag="new_3059402_3059490_c" /HighExp="HiOs, M40t90, T0.30H, T1.30H, T3.0H, T1.0H, Sw, T2.30H, T3.30H, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1145" promotor_-10 complement(2481848..2481867) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2481850) /Source="Nicolas_upshifts" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2481883..2481887) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2481907..2482548) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /EC_number="2.1.1.33" /function="16.6: Maintain" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15789416, 16600901, 17150909, 19934251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15789416, 16600901, 17150909, 19934251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="NP_390868.1" /db_xref="EnsemblGenomes-Gn:BSU29900" /db_xref="EnsemblGenomes-Tr:CAB14968" /db_xref="GOA:O34522" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR029063" /db_xref="PDB:2FCA" /db_xref="SubtiList:BG13890" /db_xref="UniProtKB/Swiss-Prot:O34522" /translation="MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIE VGTGKGQFISGMAKQNPDINYIGIELFKSVIVTAVQKVKDSEAQNVKLLNIDADTLTD VFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYEEVMGKGGSIHFKTDNRGLFE YSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVEWRT*" /label="trmB CDS" gene complement(2481907..2482548) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /label="trmB gene" downshifts complement(2481917) /Source="Nicolas_upshifts" /id="D1541" /incds=0 /nref=46 /ntot=131 /MaxReadThrough="3.31031" /MaxDrop="5.64644" /score="29.2137061" /energy="-10.1" /TU="NA" /idTUdmin="U2321" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(2481982) /Source="Nicolas_upshifts" /id="D1542" /incds=1 /nref=39 /ntot=202 /MaxReadThrough="6.31908" /MaxDrop="3.64275" /score="29.2137061" /energy="-10.1" /TU="U2321,U2323" /idTUdmin="U2323" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2482574..2482593) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2482583) /Source="Nicolas_upshifts" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2482585..2483033) /Source="Nicolas_S_feature" /locus_tag="new_3060225_3060673_c" /HighExp="C30, Cold, G135, G180, B60, Paraq, G150, Oxctl, H2O2, LBGstat" /AntisenseName="ytzH" /AntisenseCor="-0.51149457663808795" /AntisenseRegPval="-18.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1146" promotor_-35 complement(2482609..2482613) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2482692..2482698 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2482713..2482724 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2482720 /Source="Nicolas_upshifts" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="upshifts" CDS 2482755..2483033 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390869.1" /db_xref="EnsemblGenomes-Gn:BSU29910" /db_xref="EnsemblGenomes-Tr:CAB14969" /db_xref="InterPro:IPR025547" /db_xref="SubtiList:BG13942" /db_xref="UniProtKB/Swiss-Prot:O32066" /translation="MGLHYEHQVHLLKDILTDHQLDCCGTVAEYEQLERVIKSLMANT ELDSNFKNVLEDVYRYSQSGISSKSIDSHIQEHQNSLSQWVEQMDSYS*" /label="ytzH CDS" gene 2482755..2483033 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /label="ytzH gene" S_feature 2483034..2483204 /Source="Nicolas_S_feature" /locus_tag="new_3060674_3060844" /HighExp="S5, S7, S8, S6, S4, BT, C30, nit, ferm, G/S" /AntisenseName="ytmP" /AntisenseCor="-0.32108027439793901" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1147" CDS complement(2483034..2483648) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9026440, 11545674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase/phosphotransferase" /protein_id="NP_390870.2" /db_xref="EnsemblGenomes-Gn:BSU29920" /db_xref="EnsemblGenomes-Tr:CAB14970" /db_xref="GOA:C0SPC1" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG13889" /db_xref="UniProtKB/Swiss-Prot:C0SPC1" /translation="MENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDM LKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDV NHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESL RLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD*" /label="ytmP CDS" gene complement(2483034..2483648) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /label="ytmP gene" downshifts 2483182 /Source="Nicolas_upshifts" /id="D1543" /incds=1 /nref=4 /ntot=35 /MaxReadThrough="2.54837" /MaxDrop="3.82368" /score="-4.89809956" /energy="-11.3" /TU="NA" /idTUdmin="U2322" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2483649..2483984) /Source="Nicolas_S_feature" /locus_tag="new_3061289_3061624_c" /HighExp="T1.30H, M9-stat, T2.30H, T3.0H, UNK1, B60, T2.0H, T3.30H, T1.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1148" promotor_-10 complement(2483976..2483995) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2483984) /Source="Nicolas_upshifts" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2484010..2484017) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2484011..2486167) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /EC_number="3.2.1.41" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9453151, 16582490, 19465663, 23973973" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9453151, 16582490, 19465663, 23973973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pullulanase" /protein_id="NP_390871.2" /db_xref="EnsemblGenomes-Gn:BSU29930" /db_xref="EnsemblGenomes-Tr:CAB14971" /db_xref="GOA:C0SPA0" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR011840" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="PDB:2E8Y" /db_xref="PDB:2E8Z" /db_xref="PDB:2E9B" /db_xref="SubtiList:BG12566" /db_xref="UniProtKB/Swiss-Prot:C0SPA0" /translation="MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFP LAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYY DGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLH GYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIY ETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDF AGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVIL DVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVV YWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAA LANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALA PIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIH SGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSA ADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLC DPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA*" /label="amyX CDS" gene complement(2484011..2486167) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /label="amyX gene" Polymorphism join(2485708,2485710) /Source="geneious" /ID="SNP_BsDelta6_3063349_3063349" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=459 /Change="A -> G" /Codon_Change="GTT -> GTC" /Coverage=168 /locus_tag="BSU_29930" /Protein_Effect="None" /Reference_Frequency="1.2%" /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=165 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2486193..2487122) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /EC_number="2.7.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospholipid kinase" /protein_id="NP_390872.1" /db_xref="EnsemblGenomes-Gn:BSU29940" /db_xref="EnsemblGenomes-Tr:CAB14972" /db_xref="GOA:O34799" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13880" /db_xref="UniProtKB/Swiss-Prot:O34799" /translation="MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPG HAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRG FSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAME FPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFY GGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITF YTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT*" /label="ytlR CDS" gene complement(2486193..2487122) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /label="ytlR gene" CDS complement(2487171..2488085) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390873.1" /db_xref="EnsemblGenomes-Gn:BSU29950" /db_xref="EnsemblGenomes-Tr:CAB14973" /db_xref="InterPro:IPR012397" /db_xref="SubtiList:BG13879" /db_xref="UniProtKB/Swiss-Prot:O34471" /translation="MAQIIKIHDYISRYELDPYHYINQFVRLKKERWLSLVEAAERQH EERQASAEEPEPVQKRKKFSLKRRKEEIKADIQEERHQWFEDEEDIHVRLPKSRVALA SFYKRHLYDFQLKWASSTLSEISQLSNQVKQDRILRYLTQQLPDSYFIMYKPVLKIQQ AAVELSIVIISPLEIYCVSFLEAEEDSVYIGSKNRFWDKKTASQTASVLNPGLSLFRT DSVVSKIVKEKQAEIPVRKLLLSRTSYIDYPEPPYGLEIADKRSAEEWIERQKKNTAP IKHHQVKAAKALLSYCMSDSYRRQEWLE*" /label="ytlQ CDS" gene complement(2487171..2488085) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /label="ytlQ gene" promotor_-10 complement(2487848..2487866) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2487856) /Source="Nicolas_upshifts" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2487880..2487886) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" CDS complement(2488111..2488662) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /EC_number="3.1.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17012785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA 2',3'-cyclic phosphodiesterase" /protein_id="NP_390874.1" /db_xref="EnsemblGenomes-Gn:BSU29960" /db_xref="EnsemblGenomes-Tr:CAB14974" /db_xref="GOA:O34570" /db_xref="InterPro:IPR004175" /db_xref="InterPro:IPR009097" /db_xref="SubtiList:BG13878" /db_xref="UniProtKB/Swiss-Prot:O34570" /translation="MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYH ITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNK TLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAER FSLFQIHLNQSPKYEEIFKFQLS*" /label="ytlP CDS" gene complement(2488111..2488662) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /label="ytlP gene" misc_feature 2488525..2488544 /Source="Nicolas_upshift_promotors" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2488528 /Source="Nicolas_upshifts" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2488685..2488704) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2488697) /Source="Nicolas_upshifts" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2488720..2488723) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" promotor_-35 2488745..2488752 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2488763..2488782 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2488766..2488777) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2488770 /Source="Nicolas_upshifts" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2488780) /Source="Nicolas_upshifts" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2488791..2488797) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2488811..2489746 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cysteine synthase-like enzyme" /protein_id="NP_390875.1" /db_xref="EnsemblGenomes-Gn:BSU29970" /db_xref="EnsemblGenomes-Tr:CAB14975" /db_xref="GOA:O34476" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG13872" /db_xref="UniProtKB/Swiss-Prot:O34476" /translation="MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSV KDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKE RINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTA PEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGK PGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACF AAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI*" /label="ytkP CDS" gene 2488811..2489746 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /label="ytkP gene" downshifts 2489722 /Source="Nicolas_upshifts" /id="D1544" /incds=0 /nref=74 /ntot=225 /MaxReadThrough="2.5873" /MaxDrop="4.59197" /score="29.2734118" /energy="-18.2" /TU="NA" /idTUdmin="U2327" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(2489780..2491171) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /EC_number="3.5.-.-" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7528082, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative promiscuous peptidase/deacylase" /protein_id="NP_390876.1" /db_xref="EnsemblGenomes-Gn:BSU29980" /db_xref="EnsemblGenomes-Tr:CAB14976" /db_xref="GOA:O34944" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010964" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13867" /db_xref="UniProtKB/Swiss-Prot:O34944" /translation="MNWEVEVIRKKEDLIRDTQEFLRINSVMDETTAGPGKPFGEGVN ASLTSLLELGEKEGFTTKNLDGFAGHIEWGEGDDIIGVLCHVDVVPPGDGWTSDPFSA EIRNGRIYARGAIDDKGPTMAAFYALKIVKDMNLPLSKRVRMIIGTDEESDWRCVEHY FKHEEMPTMGFAPDADFPIINAEKGIIDASLLIPHRPNQAEPKAVLVSFQSGLRLNMV PDAAEAVIEGPKNEEILSSFKDMLRTTDQKGEAAIENGQLILRMYGLSCHAMEPNNGI NAGILLCEFLQQTELDDAGKRFVQVVTDKFSGDTRGKKLDIDCEDEISGELTLNVGTL RYKEGQGGELGINIRYPVTAESKVIRDTFESASEFELGEFKDSKPHHVSADHPLVKTL QKVYEGQLGKKADLISIGGGTYARSLKAGVAFGPLFPGRPDSAHQKDEYIEIDDLLRS TALYAQAIYELAK*" /label="ytjP CDS" gene complement(2489780..2491171) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /label="ytjP gene" downshifts complement(2489792) /Source="Nicolas_upshifts" /id="D1545" /incds=0 /nref=63 /ntot=240 /MaxReadThrough="3.38616" /MaxDrop="3.73023" /score="23.9099234" /energy="-14.4" /TU="U2330" /idTUdmin="U2330" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature complement(2491172..2491612) /Source="Nicolas_S_feature" /locus_tag="new_3068812_3069252_c" /HighExp="Etha, Salt, M40t90, Lbtran, T1.30H, M0t90, Lbstat, T1.0H, T0.30H, LBGstat" /AntisenseName="pbuO" /AntisenseCor="-0.324692399913451" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1149" promotor_-35 2491198..2491203 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2491217..2491236 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2491230 /Source="Nicolas_upshifts" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="upshifts" CDS 2491268..2492566 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11591660, 12923093, 15849754, 16850406, 19446032, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12923093, 15849754, 16850406, 19446032, 28583948; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_390877.1" /db_xref="EnsemblGenomes-Gn:BSU29990" /db_xref="EnsemblGenomes-Tr:CAB14977" /db_xref="GOA:O34978" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG13864" /db_xref="UniProtKB/Swiss-Prot:O34978" /translation="MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFD QVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAV FTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLV TLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSL PHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKL PNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLTALTVAVMFAASMFF SPLVSALSGIAAITSPALIIVGSLMMGSVSNMNWKEMDEAFPAFLVILAMPLTSSIST GIALGFISYPIVKAARGKWREIHPLVIVFAILFFIQLFIL*" /label="pbuO CDS" gene 2491268..2492566 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /label="pbuO gene" promotor_-10 complement(2491589..2491608) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2491612) /Source="Nicolas_upshifts" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2491623..2491629) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2492553 /Source="Nicolas_upshifts" /id="D1546" /incds=0 /nref=43 /ntot=178 /MaxReadThrough="2.37859" /MaxDrop="5.35341" /score="16.9979166" /energy="-10.2" /TU="NA" /idTUdmin="U2329" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2492606..2493763) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390878.1" /db_xref="EnsemblGenomes-Gn:BSU30000" /db_xref="EnsemblGenomes-Tr:CAB14978" /db_xref="GOA:O35029" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG13861" /db_xref="UniProtKB/Swiss-Prot:O35029" /translation="MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIY QYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQ LKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQ DRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTA SFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTI CTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTL IFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT*" /label="ythQ CDS" gene complement(2492606..2493763) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /label="ythQ gene" downshifts complement(2492631) /Source="Nicolas_upshifts" /id="D1547" /incds=0 /nref=1 /ntot=153 /MaxReadThrough="3.07175" /MaxDrop="3.89104" /score="19.8243425" /energy="-11.2" /TU="NA" /idTUdmin="U2332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2492879..2492884 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2492899..2492917 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2492907 /Source="Nicolas_upshifts" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2493760..2494470) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_390879.1" /db_xref="EnsemblGenomes-Gn:BSU30010" /db_xref="EnsemblGenomes-Tr:CAB14979" /db_xref="GOA:O34977" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13860" /db_xref="UniProtKB/Swiss-Prot:O34977" /translation="MTNLLEASIEQAGYTSRKKVLTDVFLEVRKGELVGLIGANGAGK STAIKAILGLSEDFKGHIAWNDCSFAYIPEHPSFYEELTLWEHLDLISTLHGIEESEF AHRAQSLLQTFSLDHVKHELPVTFSKGMQQKLMLIQAFLSKPDMYVIDEPFIGLDPIS TKRFVDMLKAEKERGAGILMCTHVLDTAEKICDRFYMIEKGSLFLQGTLKDVQDKTGL EGQSLLDCFYKAVQGDRL*" /label="ythP CDS" gene complement(2493760..2494470) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /label="ythP gene" promotor_-10 complement(2494484..2494499) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2494501) /Source="Nicolas_upshifts" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2494511..2494520) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2494527..2494528 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2494540..2494645 /Source="Nicolas_S_feature" /locus_tag="new_3072180_3072285" /HighExp="S5, S4, S3, S8, S7, S6, G/S, Pyr, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1150" upshifts 2494540 /Source="Nicolas_upshifts" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2494548..2494558 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2494611..2494617 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2494632..2494651 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2494647..2494760 /Source="Nicolas_S_feature" /locus_tag="new_3072287_3072400" /HighExp="S4, S5, M0t90, S3, Etha, M9-stat, M40t90, LPhT, Heat, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1151" upshifts 2494647 /Source="Nicolas_upshifts" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2494761..2494982 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618461; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (DeoR family)" /protein_id="NP_390880.1" /db_xref="EnsemblGenomes-Gn:BSU30020" /db_xref="EnsemblGenomes-Tr:CAB14980" /db_xref="GOA:O32067" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13939" /db_xref="UniProtKB/Swiss-Prot:O32067" /translation="MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRD LNVLAYNDLVHSPSRGKWETTRKKVKITS*" /label="ytzE CDS" gene 2494761..2494982 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /label="ytzE gene" downshifts 2494965 /Source="Nicolas_upshifts" /id="D1548" /incds=0 /nref=166 /ntot=259 /MaxReadThrough="4.38243" /MaxDrop="4.90218" /score="20.9755494" /energy="-13.5" /TU="U2333,U2334" /idTUdmin="U2333" /TUdmin="-54" /isTUend="FALSE" /label="downshifts" downshifts 2495034 /Source="Nicolas_upshifts" /id="D1549" /incds=0 /nref=44 /ntot=172 /MaxReadThrough="-0.189589999999999" /MaxDrop="6.00369" /score="20.9755494" /energy="-13.5" /TU="NA" /idTUdmin="U2334" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2495103..2495822) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /EC_number="4.2.1.70" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11953756, 16511038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA pseudouridylate 516 synthase" /protein_id="NP_390882.2" /db_xref="EnsemblGenomes-Gn:BSU30035" /db_xref="EnsemblGenomes-Tr:CAB14982" /db_xref="GOA:O32068" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG13941" /db_xref="UniProtKB/Swiss-Prot:O32068" /translation="MRLDKLLANSGYGSRKEVKAVVKAGAVMIDGKPAKDVKEHVDPD TQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPAGRL DKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGYK TKPAKAEIKTNDSGNTVIYLTITEGKYHQVKQMAKAVGNEVVYLKRLSMGRVSLDPAL APGEYRELTEEELHLLNEPQA*" /label="rsuA CDS" gene complement(2495103..2495822) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /label="rsuA gene" downshifts complement(2495117) /Source="Nicolas_upshifts" /id="D1550" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="0.79865" /MaxDrop="2.6873" /score="21.6808891" /energy="-13.5" /TU="NA" /idTUdmin="U2335" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2495888) /Source="Nicolas_upshifts" /id="D1551" /incds=0 /nref=1 /ntot=76 /MaxReadThrough="4.50848" /MaxDrop="2.99899" /score="8.79816042" /energy="-9.5" /TU="U2335" /idTUdmin="U2335" /TUdmin="-617" /isTUend="FALSE" /label="downshifts" CDS complement(2495891..2497525) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_390883.1" /db_xref="EnsemblGenomes-Gn:BSU30050" /db_xref="EnsemblGenomes-Tr:CAB14983" /db_xref="GOA:O34674" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG13856" /db_xref="UniProtKB/Swiss-Prot:O34674" /translation="MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQY GYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFIL YLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT AVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNK RKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIE AGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQ TMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVN AAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIM IKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAA AVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG*" /label="murJ CDS" gene complement(2495891..2497525) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /label="murJ gene" misc_feature complement(2497557..2497576) /Source="Nicolas_upshift_promotors" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2497573) /Source="Nicolas_upshifts" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2497643..2497647 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2497663..2497682 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2497681 /Source="Nicolas_upshifts" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2497727..2498989 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(FAD)-utilizing dehydrogenase" /protein_id="NP_390884.2" /db_xref="EnsemblGenomes-Gn:BSU30060" /db_xref="EnsemblGenomes-Tr:CAB14984" /db_xref="InterPro:IPR004792" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13850" /db_xref="UniProtKB/Swiss-Prot:Q795R8" /translation="MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAI SGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGR MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAV IIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRD VAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPD INEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPF RQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIH GYTGGYNITSALVTGRLAGLNAGQYARS*" /label="ytfP CDS" gene 2497727..2498989 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /label="ytfP gene" S_feature 2498990..2499088 /Source="Nicolas_S_feature" /locus_tag="new_3076630_3076728" /HighExp="LBGstat, Lbstat, M0t90, T2.30H, T1.0H, T0.30H, BC, T2.0H, T1.30H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1152" promotor_-35 2499062..2499068 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2499084..2499102 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2499090..2499177 /Source="Nicolas_S_feature" /locus_tag="new_3076730_3076817" /HighExp="Etha, LBGstat, Salt, M9-stat, Lbstat, LBGtran, Sw, C30, Gly, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1153" upshifts 2499090 /Source="Nicolas_upshifts" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2499178..2500716 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14996799, 15849754, 16850406, 8752321, 9925583" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14996799, 15849754, 16850406, 8752321, 9925583; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine transporter" /protein_id="NP_390885.1" /db_xref="EnsemblGenomes-Gn:BSU30070" /db_xref="EnsemblGenomes-Tr:CAB14985" /db_xref="GOA:P54417" /db_xref="InterPro:IPR000060" /db_xref="InterPro:IPR018093" /db_xref="SubtiList:BG11958" /db_xref="UniProtKB/Swiss-Prot:P54417" /translation="MLKHISSVFWIVIAITAAAVLWGVISPDSLQNVSQSAQAFITDS FGWYYLLVVSLFVGFCLFLIFSPIGKIKLGKPDEKPEFGLLSWFAMLFSAGMGIGLVF YGAAEPISHYAISSPSGETETPQAFRDALRYTFFHWGLHAWAIYAIVALCIAYFQFRK GAPGLISSTLSPILGDKVNGPIGKAIDCIAVFATVVGVSTSLGLGATQINGGLNYLFG IPNAFIVQLVLIIIVTVLFLLSAWSGLGKGIKYLSNTNMVLAGLLMLFMLVVGPTVLI MNSFTDSIGQYIQNIVQMSFRLTPNDPEKREWINSWTIFYWAWWISWSPFVGIFIARV SRGRTIREFLIGVLVTPCILTFLWFSIFGVSAMDLQQKGAFNVAKLSTETMLFGTLDH YPLTMVTSILALILIAVFFITSADSATFVLGMQTSYGSLNPANSVKLSWGIIQSAMAA VLLYSGGLAALQNTAILAALPFSIVILLMIASLYQSLSKERREIKKAEKLDKPRSPRV KKAY*" /label="opuD CDS" gene 2499178..2500716 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /label="opuD gene" downshifts 2500696 /Source="Nicolas_upshifts" /id="D1552" /incds=0 /nref=231 /ntot=263 /MaxReadThrough="2.0688" /MaxDrop="6.06429" /score="27.1497809" /energy="-16.3" /TU="NA" /idTUdmin="U2336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2500753..2500935) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8990290" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390886.1" /db_xref="EnsemblGenomes-Gn:BSU30080" /db_xref="EnsemblGenomes-Tr:CAB14986" /db_xref="GOA:P94496" /db_xref="InterPro:IPR020296" /db_xref="SubtiList:BG12339" /db_xref="UniProtKB/Swiss-Prot:P94496" /translation="MLKVAVFDEEHEKDLQTEINSFLKGISEEQLIDIKYTVSAACDP DGEQLYCFSALILYRK*" /label="yteV CDS" gene complement(2500753..2500935) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /label="yteV gene" downshifts complement(2500772) /Source="Nicolas_upshifts" /id="D1553" /incds=0 /nref=10 /ntot=61 /MaxReadThrough="0.597819999999999" /MaxDrop="4.78152" /score="32.507978" /energy="-16.3" /TU="NA" /idTUdmin="U2338" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2500950..2500968) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2500970) /Source="Nicolas_upshifts" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2500984..2500989) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2501003..2501671) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme for rhamnogalaturonan degradation" /protein_id="NP_390887.1" /db_xref="EnsemblGenomes-Gn:BSU30090" /db_xref="EnsemblGenomes-Tr:CAB14987" /db_xref="GOA:O34378" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG13846" /db_xref="UniProtKB/Swiss-Prot:O34378" /translation="MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPAT AALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPS HFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTML ALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFY PETR*" /label="rmgU CDS" gene complement(2501003..2501671) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /label="rmgU gene" CDS complement(2501693..2502979) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase of rhamnogalaturonan degradation" /protein_id="NP_390888.1" /db_xref="EnsemblGenomes-Gn:BSU30100" /db_xref="EnsemblGenomes-Tr:CAB14988" /db_xref="GOA:O34371" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13845" /db_xref="UniProtKB/Swiss-Prot:O34371" /translation="MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAV CKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEK PMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWY IDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPD SEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPD ACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEP SRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILA GAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV*" /label="rmgT CDS" gene complement(2501693..2502979) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /label="rmgT gene" CDS complement(2502991..2503494) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17449691, 23504016; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein required for rhamnogalaturonan transport and degradation" /protein_id="NP_390889.2" /db_xref="EnsemblGenomes-Gn:BSU30110" /db_xref="EnsemblGenomes-Tr:CAB14989" /db_xref="GOA:C0SP80" /db_xref="SubtiList:BG13844" /db_xref="UniProtKB/Swiss-Prot:C0SP80" /translation="MTKRIRTALCVIVSVLFLASCSSRPDGMHVILFSDMQAGVQEKI KKAAEQNAGKVDIFPAFQEKLLTEITAHEGDVFIVPEDMFQAYDDPENFQPLNGLPPE KTSPYTTVNKKTGEKTIYAVQIEKGKKQLNGYSFQLNRDMAAFIPVYAEKTEEALQLI SQLTEAR*" /label="rmgS CDS" gene complement(2502991..2503494) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /label="rmgS gene" CDS complement(2503491..2504612) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /EC_number="3.2.1.172" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15148314, 15906318, 16781735, 16870154, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15148314, 15906318, 16781735, 16870154, 17449691, 23504016; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="unsaturated rhamnogalacturonyl hydrolase" /protein_id="NP_390890.3" /db_xref="EnsemblGenomes-Gn:BSU30120" /db_xref="EnsemblGenomes-Tr:CAB14990" /db_xref="GOA:O34559" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="PDB:1NC5" /db_xref="PDB:2D8L" /db_xref="PDB:2GH4" /db_xref="SubtiList:BG13843" /db_xref="UniProtKB/Swiss-Prot:O34559" /translation="MGSMDQSIAVKSPLTYAEALANTIMNTYTVEELPPANRWHYHQG VFLCGVLRLWEATGEKRYFEYAKAYADLLIDDNGNLLFRRDELDAIQAGLILFPLYEQ TKDERYVKAAKRLRSLYGTLNRTSEGGFWHKDGYPYQMWLDGLYMGGPFALKYANLKQ ETELFDQVVLQESLMRKHTKDAKTGLFYHAWDEAKKMPWANEETGCSPEFWARSIGWY VMSLADMIEELPKKHPNRHVWKNTLQDMIKSICRYQDKETGLWYQIVDKGDRSDNWLE SSGSCLYMYAIAKGINKGYLDRAYETTLLKAYQGLIQHKTETSEDGAFLVKDICVGTS AGFYDYYVSRERSTNDLHGAGAFILAMTELEPLFRSAGK*" /label="rmgQ CDS" gene complement(2503491..2504612) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /label="rmgQ gene" CDS complement(2504620..2505585) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease for unsaturated rhamnogalacturonan" /protein_id="NP_390892.2" /db_xref="EnsemblGenomes-Gn:BSU30135" /db_xref="EnsemblGenomes-Tr:CAB14992" /db_xref="GOA:C0SPB3" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13841" /db_xref="UniProtKB/Swiss-Prot:C0SPB3" /translation="MKTAEAQAPAVDAVIFKKEKRKRLLIKLIQQKYLYLMILPGCIY FLLFKYVPMWGIVIAFQDYQPFLGILGSEWVGLKHFIRLFTEPTFFLLLKNTLVLFAL NLAIFFPVPILLALLLNEVRIALFKKFVQTLIYIPHFMSWVIVVSLSFVLLTVDGGLI NELIVFFGGEKINFLLNEEWFRPLYILQVIWREAGWSTIIYLAAITAVDPQLYEAAKM DGAGRLRQMWHITLPAIKSVIVVLLILKIGDTLELGFEHVYLLLNATNREVAEIFDTY VYTAGLKQGQFSYSTAVGVFKAAVGLILVMLANRLAKKFGEEGIY*" /label="rmgP CDS" gene complement(2504620..2505585) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /label="rmgP gene" upshifts complement(2505611) /Source="Nicolas_upshifts" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2505612..2505631) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2505646..2505653) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2505741..2505748 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2505761 /Source="Nicolas_upshifts" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2505764..2505783 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2505801..2508119 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="membrane bound transcriptional regulator (controlling rhamnogalacturonan degradation)" /protein_id="NP_390893.1" /db_xref="EnsemblGenomes-Gn:BSU30150" /db_xref="EnsemblGenomes-Tr:CAB14993" /db_xref="GOA:O32071" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG13838" /db_xref="UniProtKB/Swiss-Prot:O32071" /translation="MGGFMKRSQYKFYYKLITFFCLLSTIPVILVGLFSYEHSQKTAI SNVSEEKFDTLQQTQQSIEHILKTVDHSLTHYVSSPPLLRTLSEPLHSDQFQIYNQVN QELNYLQSFDTDLSNMTLVSYTKKWYMNNSGLYRLNTDTLHEAASAYTKQKASRSYWT LEENNHLISTKEGTAENCRYNINLIKQLPLNSTNTKGLAAASIPSCSLVKNMPGYSNA NNLFIIDEKGLIILHNNMSDVGESLHNDGFVQKVLAQTANSGQFETVIDRIHYKVTYQ KSDYNAWTYFSLVSLPELKKEAKSIGWITFAVCLILLTLSLLFSWLGSRHFYKPIRVL YESFARHGAIQEKQQPPQNEFELIEQSFKQLKDRNDDLEETMKQQATHLQQYFMVRLM LGKLTDEEVDNRFESLGLKQNWRHLALLVLQIDTLNHTPYEKKDMDLLLFAVNSLIER NIPTDKHLAPAVVDKQQATILINQSGTKEEFMAELNETARMIQEKAEAELQLSVSIGI SQPFDVLTKAKTAYAEGSEALKYRLKAENKSIIFYEDLDQKKTFKTHFPKQLQHELFD AVKAGDKEKADKCLHAILQAIFTQNTNPYQFQIAIARFLNHVIELMHVLGIELFELEE NKMLYDQIFELKTFEDTENWLKNEFIDPMTDKVNARADAQYKNISDNIIHIIHHEFES ELTLDEIARRLHYNPNYLSSIFKKEMGISFSEYVSSYRHHMAKSWLAETDMAVKDIAE KLKYKNSQNFIRSFKKLEGITPGNYRQQKRSM*" /label="rmgR CDS" gene 2505801..2508119 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /label="rmgR gene" downshifts 2508109 /Source="Nicolas_upshifts" /id="D1554" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="1.43431" /MaxDrop="3.6268" /score="-7.37324741" /energy="-10.2" /TU="NA" /idTUdmin="U2340" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" CDS complement(2508160..2509656) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_390894.3" /db_xref="EnsemblGenomes-Gn:BSU30160" /db_xref="EnsemblGenomes-Tr:CAB14994" /db_xref="GOA:Q795R2" /db_xref="SubtiList:BG13836" /db_xref="UniProtKB/Swiss-Prot:Q795R2" /translation="MGNKWRVLLIVLVLALGGVLAGCKGTDQSSAEGKAGPDSKVKLS WMAILYHQQPPKDRAIKEIEKLTNTELDITWVPDAVKEDRLNAALAAGNLPQIVTIQD IKNSSVMNAFRSGMFWEIGDYIKDYPNLNKMNKLINKNVTIDGKLYGIYRERPLSRQG IVIRKDWLDNLNLKTPKTLDELYEVAKAFTEDDPDKDGKDDTFGLADRNDLIYGAFKT IGSYEGMPTDWKESGGKFTPDFMTQEYKDTMNYMKKLRDNGYMNKDFPVTSKTQQQEL FSQGKAGIYIGNMVDAVNLRDHASDKSMKLEIINRIKGPDGKERVWASGGHNGVFAFP KTSVKTEAELKRILAFFDRIAEEDVYSLMTYGIDGVHYNKGEDKTFTRKESQVKDWQT DIQPLSALIAIDKAYLKNTGDPLRTAYEELTEDNEKIIVSNPAESLYSASESERGDEL KKIIDDATYKYMIGDITESQFDKEVEKWESSGGKQIIQEYEEAFKQAK*" /label="ytcQ CDS" gene complement(2508160..2509656) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /label="ytcQ gene" downshifts complement(2508162) /Source="Nicolas_upshifts" /id="D1555" /incds=0 /nref=26 /ntot=160 /MaxReadThrough="-0.0485899999999999" /MaxDrop="5.21039" /score="6.31011081" /energy="-11.2" /TU="NA" /idTUdmin="U2341" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2509681..2510541) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390895.1" /db_xref="EnsemblGenomes-Gn:BSU30170" /db_xref="EnsemblGenomes-Tr:CAB14995" /db_xref="GOA:P53561" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11788" /db_xref="UniProtKB/Swiss-Prot:P53561" /translation="MKNRLFDMLIYGFLLMFALICVLPFIHVIAASFATVEEVVSKKF ILIPTTFSLDAYRYIFSTDIIYKSLLVSVFVTVIGTAVSMFLSSLMAYGLSRRDLIGR QPLMFLVVFTMLFSGGMIPTFLVVKSLGLLDSYWALILPTAINAFNLIILKNFFQNIP SSLEESAKIDGCNDLGIFFKIVLPLSLPAIATISLFYAVTYWNTYMTAILYLNDSAKW PIQVLLRQIVIVSSGMQGDMSEMGSGSPPPEQTIKMAVIVVATIPVLLVYPFIQKHFA KGALLGSVKG*" /label="ytcP CDS" gene complement(2509681..2510541) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /label="ytcP gene" promotor_-10 complement(2510617..2510636) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2510626) /Source="Nicolas_upshifts" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2510652..2510659) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2510748..2511509) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-dependent nucleoside-diphosphate-sugar epimerase" /protein_id="NP_390896.2" /db_xref="EnsemblGenomes-Gn:BSU30180" /db_xref="EnsemblGenomes-Tr:CAB14996" /db_xref="GOA:P53560" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11787" /db_xref="UniProtKB/Swiss-Prot:P53560" /translation="MKKVLIAGGNGVIGRLLAEGLISDYEVTVLDKDHFDGKASSIQA DAANYEELLKKIPKDTDAILNLLAVKIKYDIMDIAEFEKMTDVFYRASYYLCRAAAEL GIQKLVFASSNHVTDVYEKDGRSLLGREITTSDYPLSKNLYGVLKLTSEQIGHLFYLE NKLSVINLRIGTVVTDEMDTLHEKERTKKTLLSHPDLLSIFKAAIETNIRYGTYYAVS DNPGRPWSIESAVNELGFSPQINTAELLNEEENGA*" /label="ytbQ CDS" gene complement(2510748..2511509) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /label="ytbQ gene" downshifts complement(2510777) /Source="Nicolas_upshifts" /id="D1556" /incds=0 /nref=153 /ntot=196 /MaxReadThrough="1.18543" /MaxDrop="5.85654" /score="12.3836957" /energy="-11.1" /TU="NA" /idTUdmin="U2344" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2511510..2511585) /Source="Nicolas_S_feature" /locus_tag="new_3089150_3089225_c" /HighExp="LPh, HPh, aero, Gly, HiOs, BMM, GM-0.1, GM 10, GM 15, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1154" CDS complement(2511586..2512773) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /EC_number="1.14.14.46" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 for pimelic acid formation for biotin biosynthesis" /protein_id="NP_390897.1" /db_xref="EnsemblGenomes-Gn:BSU30190" /db_xref="EnsemblGenomes-Tr:CAB14997" /db_xref="GOA:P53554" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:3EJB" /db_xref="PDB:3EJD" /db_xref="PDB:3EJE" /db_xref="SubtiList:BG11528" /db_xref="UniProtKB/Swiss-Prot:P53554" /translation="MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV TFE*" /label="bioI CDS" gene complement(2511586..2512773) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /label="bioI gene" CDS complement(2512842..2513849) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /EC_number="2.8.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin synthase" /protein_id="NP_390898.1" /db_xref="EnsemblGenomes-Gn:BSU30200" /db_xref="EnsemblGenomes-Tr:CAB14998" /db_xref="GOA:P53557" /db_xref="InterPro:IPR002684" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010722" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024177" /db_xref="SubtiList:BG11525" /db_xref="UniProtKB/Swiss-Prot:P53557" /translation="MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIR KHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHD LNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGV DRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDI AKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGR EVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAK S*" /label="bioB CDS" gene complement(2512842..2513849) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /label="bioB gene" CDS complement(2513852..2514547) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /EC_number="6.3.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242, 20565114" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242, 20565114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dethiobiotin synthetase" /protein_id="NP_390899.1" /db_xref="EnsemblGenomes-Gn:BSU30210" /db_xref="EnsemblGenomes-Tr:CAB14999" /db_xref="GOA:P53558" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11526" /db_xref="UniProtKB/Swiss-Prot:P53558" /translation="MRGFFVTGTDTEVGKTVISSGLAALLKDNNRHVGVYKPFLSGIS RHHPDSDTSLLKDMSQTSLSHEDITPFAFKAPLAPYVAGKLEGKTVTMEEVLSHWGRI REKHECFIVEGAGGISVPLGEDYLVSHVIKALQLPMIIVARPRLGTINHTFLTVKYAE SMGLPIAGIIINGISDSPDEDEKTNPEMIERLCGVPILGVTPKLANVTKETVLHMVKD HINLSLLMNQVGV*" /label="bioD CDS" gene complement(2513852..2514547) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /label="bioD gene" CDS complement(2514544..2515713) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11322938, 11717296, 12368242, 15056910, 16557306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11322938, 11717296, 12368242, 15056910, 16557306; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="8-amino-7-oxononanoate synthase (pimeloyl-CoA-dependent)" /protein_id="NP_390900.1" /db_xref="EnsemblGenomes-Gn:BSU30220" /db_xref="EnsemblGenomes-Tr:CAB15000" /db_xref="GOA:P53556" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11527" /db_xref="UniProtKB/Swiss-Prot:P53556" /translation="MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVW SSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAA LLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLEN KLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQ GTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAA AHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFA EKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII*" /label="bioFC CDS" gene complement(2514544..2515713) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /label="bioFC gene" promotor_-35 2514580..2514587 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2514602..2514621 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2514620 /Source="Nicolas_upshifts" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2515703..2517049) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /EC_number="2.6.1.105" /function="4.1: Biotin" /experiment="publication(s) with functional evidences, PMID:15880481, 20565114, 21437340" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15880481, 20565114, 21437340; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lysine-8-amino-7-oxononanoate aminotransferase" /protein_id="NP_390901.1" /db_xref="EnsemblGenomes-Gn:BSU30230" /db_xref="EnsemblGenomes-Tr:CAB15001" /db_xref="GOA:P53555" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR005815" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3DOD" /db_xref="PDB:3DRD" /db_xref="PDB:3DU4" /db_xref="SubtiList:BG11524" /db_xref="UniProtKB/Swiss-Prot:P53555" /translation="MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGK EYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPK KLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIE LFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIES MVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLM AAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLAL FESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADR RIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED*" /label="bioK CDS" gene complement(2515703..2517049) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /label="bioK gene" promotor_-35 2516119..2516123 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2516138 /Source="Nicolas_upshifts" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2516139..2516157 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2517039..2517815) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /EC_number="6.2.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11368323, 11717296, 21437340, 28196402, 29054876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11368323, 11717296, 21437340, 28196402, 29054876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-carboxyhexanoate-CoA ligase (pimeloyl-CoA synthase)" /protein_id="NP_390902.3" /db_xref="EnsemblGenomes-Gn:BSU30240" /db_xref="EnsemblGenomes-Tr:CAB15002" /db_xref="GOA:P53559" /db_xref="InterPro:IPR005499" /db_xref="PDB:5FLG" /db_xref="PDB:5FLL" /db_xref="PDB:5FM0" /db_xref="PDB:5G1F" /db_xref="SubtiList:BG11529" /db_xref="UniProtKB/Swiss-Prot:P53559" /translation="MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNA LLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEG VSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKE YGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS*" /label="bioW CDS" gene complement(2517039..2517815) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /label="bioW gene" S_feature complement(2517816..2517908) /Source="Nicolas_S_feature" /locus_tag="new_3095456_3095548_c" /HighExp="T-5.40H, GM 60, LPh, GM 25, HPh, MG 120, M9-exp, BMM, GM 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1155" promotor_-10 complement(2517894..2517913) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2517908) /Source="Nicolas_upshifts" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2517928..2517935) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2518025..2518924) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390903.1" /db_xref="EnsemblGenomes-Gn:BSU30250" /db_xref="EnsemblGenomes-Tr:CAB15003" /db_xref="GOA:O34973" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11786" /db_xref="UniProtKB/Swiss-Prot:O34973" /translation="MRAERRKQLFRLLGDLPDRRPISVETLRIEEREENIVETLLLDL NGHEKAPAYFVKPKKTEGPCPAVLFQHSHGGQYDRGKSELIEGADYLKTPSFSDELTS LGYGVLAIDHWGFGDRRGKAESEIFKEMLLTGKVMWGMMIYDSLSALDYMQSRSDVQP DRIGTIGMSMGGLMAWWTAALDDRIKVCVDLCSQVDHHVLIKTQNLDRHGFYYYVPSL AKHFSASEIQSLIAPRPHLSLVGVHDRLTPAEGVDKIEKELTAVYAGQGAADCYRVVR SASGHFETAVIRHEAVRFLQKWL*" /label="ytaP CDS" gene complement(2518025..2518924) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /label="ytaP gene" promotor_-10 complement(2518947..2518965) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2518964) /Source="Nicolas_upshifts" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2518976..2518984) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2519054..2519061 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2519077..2519096 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2519083 /Source="Nicolas_upshifts" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2519142..2520176 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12847288; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_390904.1" /db_xref="EnsemblGenomes-Gn:BSU30260" /db_xref="EnsemblGenomes-Tr:CAB15004" /db_xref="GOA:O34829" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12626" /db_xref="UniProtKB/Swiss-Prot:O34829" /translation="MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEE LGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFI TNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGI DFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQ PEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTA IVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQ SCGCTAKEVT*" /label="msmR CDS" gene 2519142..2520176 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /label="msmR gene" promotor_-35 2520125..2520132 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2520147..2520155 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2520164 /Source="Nicolas_upshifts" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2520210..2521490 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8449892, 12847288, 16707683, 18954360, 28036052; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="multiple sugar-binding lipoprotein" /protein_id="NP_390905.1" /db_xref="EnsemblGenomes-Gn:BSU30270" /db_xref="EnsemblGenomes-Tr:CAB15005" /db_xref="GOA:O34335" /db_xref="InterPro:IPR006059" /db_xref="PDB:4R6H" /db_xref="SubtiList:BG12625" /db_xref="UniProtKB/Swiss-Prot:O34335" /translation="MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSE RDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGE YTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPET MDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLIN GTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDV AQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANA KQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQEL AADILAPQDISQKLGREYKRLREQSETQGAENNE*" /label="msmE CDS" gene 2520210..2521490 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /label="msmE gene" CDS 2521483..2522394 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 12847288, 15849754, 16707683, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="carbohydrate ABC transporter (permease)" /protein_id="NP_390906.1" /db_xref="EnsemblGenomes-Gn:BSU30280" /db_xref="EnsemblGenomes-Tr:CAB15006" /db_xref="GOA:O34706" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12565" /db_xref="UniProtKB/Swiss-Prot:O34706" /translation="MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGT LITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYAL LLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALA SPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPL LMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQ GIFMAFVILIISFCALAYFKRKETEMS*" /label="msmF CDS" gene 2521483..2522394 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /label="msmF gene" CDS 2522391..2523221 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 15849754, 16707683, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="maltose and multiple sugars ABC transporter (permease)" /protein_id="NP_390907.1" /db_xref="EnsemblGenomes-Gn:BSU30290" /db_xref="EnsemblGenomes-Tr:CAB15007" /db_xref="GOA:O34518" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12564" /db_xref="UniProtKB/Swiss-Prot:O34518" /translation="MRAARTKSMRIITLLAAIVACAHFIPFYILLTTSLKAKGDYSSK WIFPADISFHNFSEAWERASLGNSFINTMIITGFSALLLIIFGSLAAYPLARRETKLN KAVFALLISIMIIPPLTSMVPLYRMVVDAGMVNTHAIAIFINTAAYMPLTVFLYSGFI RSTIPKELVEAARIDGAGMLKIFFTIVFPLLKPITATICIISCVFIWNDYQFAIFFLQ DQKVQTLTVAMAGFFGENANNLHLVAAAALMAMLPMVVLFLALQKYFIAGLSSGAVKG *" /label="msmG CDS" gene 2522391..2523221 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /label="msmG gene" promotor_-35 2523194..2523198 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2523214..2523233 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2523222 /Source="Nicolas_upshifts" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2523241..2524539 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /EC_number="3.2.1.22" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12847288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-D-galactoside galactohydrolase" /protein_id="NP_390908.1" /db_xref="EnsemblGenomes-Gn:BSU30300" /db_xref="EnsemblGenomes-Tr:CAB15008" /db_xref="GOA:O34645" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12615" /db_xref="UniProtKB/Swiss-Prot:O34645" /translation="MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQ ESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRY GLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRY TNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIK RRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLD EYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTG LITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKE AVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK*" /label="melA CDS" gene 2523241..2524539 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /label="melA gene" downshifts 2524520 /Source="Nicolas_upshifts" /id="D1557" /incds=0 /nref=12 /ntot=55 /MaxReadThrough="3.99614" /MaxDrop="3.96455" /score="26.0469828" /energy="-11.9" /TU="NA" /idTUdmin="U2346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2524561..2524872) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /EC_number="2.8.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390909.2" /db_xref="EnsemblGenomes-Gn:BSU30310" /db_xref="EnsemblGenomes-Tr:CAB15009" /db_xref="GOA:O32072" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG13932" /db_xref="UniProtKB/Swiss-Prot:O32072" /translation="MEIKEISTAALKEKIEADEELYLIDVREDEEVAEGMIPQAVHIR MGDIPEKMETLDKDKEYVFICRSGMRSMNVCKYLDEQGFKTVNVEGGMMAWEGETKPK N*" /label="ytwF CDS" gene complement(2524561..2524872) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /label="ytwF gene" downshifts complement(2524572) /Source="Nicolas_upshifts" /id="D1558" /incds=0 /nref=84 /ntot=254 /MaxReadThrough="2.71726" /MaxDrop="5.77228" /score="23.1306393" /energy="-11.9" /TU="NA" /idTUdmin="U2349" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2524896..2524915) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2524904) /Source="Nicolas_upshifts" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2524930..2524937) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2524938 /Source="Nicolas_upshifts" /id="D1559" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="0.749090000000001" /MaxDrop="4.59307" /score="20.1681452" /energy="-11.2" /TU="NA" /idTUdmin="U2346" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS complement(2524989..2527403) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /EC_number="6.1.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1317842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="leucyl-tRNA synthetase" /protein_id="NP_390910.1" /db_xref="EnsemblGenomes-Gn:BSU30320" /db_xref="EnsemblGenomes-Tr:CAB15010" /db_xref="GOA:P36430" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002302" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR025709" /db_xref="SubtiList:BG10676" /db_xref="UniProtKB/Swiss-Prot:P36430" /translation="MSFQHKEIEKKWQTYWLENKTFATLDNNEKQKFYALDMFPYPSG AGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTGNDPAVFTKQ NIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQ RNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLAPEHALVENITTAEQKE AVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA VMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIE KVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILP KTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPHN PDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQ GMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGAR RFLDRVWRLFIEDSGELNGKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGISQLMV FINEAYKATELPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWPVYDETKLV DDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADEKVKEQLEGKTIRKIIAVPGKL VNIVAN*" /label="leuS CDS" gene complement(2524989..2527403) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /label="leuS gene" downshifts complement(2524993) /Source="Nicolas_upshifts" /id="D1560" /incds=0 /nref=115 /ntot=224 /MaxReadThrough="3.2803" /MaxDrop="4.46738" /score="33.3300042" /energy="-11.2" /TU="U2350" /idTUdmin="U2350" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" S_feature complement(2527404..2527499) /Source="Nicolas_S_feature" /locus_tag="new_3105044_3105139_c" /HighExp="G150, G180, G135, LBGexp, HPh, LBGtran, Paraq, Lbexp, H2O2, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.989" /label="S1156" misc_RNA complement(2527513..2527727) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /product="T-box riboswitch specific of leucine tRNA ligase" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201, 27169680; Product type n: RNA" /function="16.3: Control" /label="tboL RNA" gene complement(2527513..2527727) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /label="tboL gene" downshifts complement(2527544) /Source="Nicolas_upshifts" /id="D1561" /incds=0 /nref=8 /ntot=38 /MaxReadThrough="6.86098" /MaxDrop="4.90189" /score="40.6873438" /energy="-16.7" /TU="U2350" /idTUdmin="U2352" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2527739..2527758) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2527760) /Source="Nicolas_upshifts" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2527764..2527769 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2527773..2527778) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2527785..2527803 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2527798..2528238 /Source="Nicolas_S_feature" /locus_tag="new_3105438_3105878" /HighExp="S4, S5, S3, S8, S7, S6, T5.0H, LoTm, C30, M9-stat" /AntisenseName="ytvB" /AntisenseCor="0.57398798861917499" /AntisenseRegPval="-24.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1157" upshifts 2527798 /Source="Nicolas_upshifts" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2527830..2528165) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16923906; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein" /protein_id="NP_390911.3" /db_xref="EnsemblGenomes-Gn:BSU30330" /db_xref="EnsemblGenomes-Tr:CAB15011" /db_xref="GOA:O34881" /db_xref="InterPro:IPR025353" /db_xref="SubtiList:BG13929" /db_xref="UniProtKB/Swiss-Prot:O34881" /translation="MKMLHQVLIACVIGGIMGILGHVKKRGRLEKPRMTKRFIYLGFL EDWFIGMTASILLVLSADPDSGIQLVILSIISGYGGEAVLRSFDFVRELNSGGEPAES KRQTKTPPE*" /label="ytvB CDS" gene complement(2527830..2528165) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /label="ytvB gene" S_feature complement(2528160..2528424) /Source="Nicolas_S_feature" /locus_tag="new_3105800_3106064_c" /HighExp="S6, S8, S7, Etha, S5, M9-stat, B60, BT, B36, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1158" promotor_-10 complement(2528409..2528428) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-10" upshifts complement(2528424) /Source="Nicolas_upshifts" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="upshifts" promotor_-35 complement(2528443..2528450) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-35" promotor_-35 2528463..2528470 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2528484..2528503 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2528500 /Source="Nicolas_upshifts" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2528502..2528569 /Source="Nicolas_S_feature" /locus_tag="new_3106142_3106209" /HighExp="M40t90, Etha, dia5, HiOs, dia15, H2O2, BC, Diami, M0t90, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1159" CDS 2528570..2529355 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="blue light GTP-binding receptor" /protein_id="NP_390912.1" /db_xref="EnsemblGenomes-Gn:BSU30340" /db_xref="EnsemblGenomes-Tr:CAB15012" /db_xref="GOA:O34627" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036513" /db_xref="PDB:1IUM" /db_xref="PDB:2MWG" /db_xref="PDB:2PR5" /db_xref="PDB:2PR6" /db_xref="PDB:4GCZ" /db_xref="SubtiList:BG13928" /db_xref="UniProtKB/Swiss-Prot:O34627" /translation="MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQ GFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMF WNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISAL PLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLT GTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM*" /label="blrA CDS" gene 2528570..2529355 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /label="blrA gene" S_feature 2529356..2529412 /Source="Nicolas_S_feature" /locus_tag="new_3106996_3107052" /HighExp="Sw, M40t90, BC, Etha, dia5, dia15, H2O2, Mt0, M0t90, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1160" CDS complement(2529592..2530785) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390913.1" /db_xref="EnsemblGenomes-Gn:BSU30350" /db_xref="EnsemblGenomes-Tr:CAB15013" /db_xref="GOA:O34546" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13925" /db_xref="UniProtKB/Swiss-Prot:O34546" /translation="MPRALKILVIGMFINVTGASFLWPLNTIYIHNHLGKSLTVAGLV LMLNSGASVAGNLCGGFLFDKIGGFKSIMLGIAITLASLMGLVFFHDWPAYIVLLTIV GFGSGVVFPASYAMAGSVWPEGGRKAFNAIYVAQNAGVAVGSALGGVVASFSFSYVFL ANAVLYLIFFFIVYFGFRNIQTGDASQTSVLDYDAVNSKAKFAALIILSGGYVLGWLA YSQWSTTIASYTQSIGISLSLYSVLWTVNGILIVLGQPLVSFVVKKWAESLKAQMVIG FIIFIVSFSMLLTAKQFPMFLAAMVILTIGEMLVWPAVPTIANQLAPKGKEGFYQGFV NSAATGGRMIGPLFGGVLVDHYGIRALVLSLLVLLLISIATTLLYDKRIKSAKETNKQ ASISS*" /label="yttB CDS" gene complement(2529592..2530785) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /label="yttB gene" downshifts complement(2529612) /Source="Nicolas_upshifts" /id="D1562" /incds=0 /nref=5 /ntot=47 /MaxReadThrough="2.03991" /MaxDrop="3.41948" /score="-7.70376219" /energy="-9.4" /TU="NA" /idTUdmin="U2354" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2530786..2530884) /Source="Nicolas_S_feature" /locus_tag="new_3108426_3108524_c" /HighExp="dia15, LBGstat, H2O2, G180, LPhT, Paraq, Oxctl, G150, G135, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1161" promotor_-10 complement(2530865..2530884) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2530884) /Source="Nicolas_upshifts" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2530898..2530905) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2530922..2530925 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2530940..2530959 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2530944 /Source="Nicolas_upshifts" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="upshifts" CDS 2530974..2531720 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390914.2" /db_xref="EnsemblGenomes-Gn:BSU30360" /db_xref="EnsemblGenomes-Tr:CAB15014" /db_xref="GOA:Q795Q5" /db_xref="InterPro:IPR006876" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG13924" /db_xref="UniProtKB/Swiss-Prot:Q795Q5" /translation="MEMVLAFLGFLACLIALGYGLYHLVRYVLKKEKRFSKRLFWPLF IGGLVLLFTGAALAEPDTAAANAEKKYSALNAEYKNLTKEHEELEKEYKSVSSEAKKL KDNKEDQDKLEKLKNENSDLKKTQKSLKAEIKELQENQKQLKEDAKTAKAENETLRQD KTKLENQLKETESQTASSHEDTGSSSNNTSKSDETKTADKAEGCNIKGSRNGIYHTPG STYYDRTTDPAEMFCSVEEAEAAGYRAPKR*" /label="yttA CDS" gene 2530974..2531720 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /label="yttA gene" downshifts 2531615 /Source="Nicolas_upshifts" /id="D1563" /incds=1 /nref=2 /ntot=94 /MaxReadThrough="4.11368" /MaxDrop="3.01036" /score="23.2955589" /energy="-11.6" /TU="U2355" /idTUdmin="U2355" /TUdmin="-99" /isTUend="FALSE" /label="downshifts" downshifts 2531714 /Source="Nicolas_upshifts" /id="D1564" /incds=0 /nref=31 /ntot=169 /MaxReadThrough="1.73994" /MaxDrop="4.19129" /score="23.2955589" /energy="-11.6" /TU="NA" /idTUdmin="U2355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2531757..2533697) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612242, 15849754, 16850406, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 15849754, 16850406, 17905982, 25118291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease)" /protein_id="NP_390915.1" /db_xref="EnsemblGenomes-Gn:BSU30370" /db_xref="EnsemblGenomes-Tr:CAB15015" /db_xref="GOA:O34741" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG13921" /db_xref="UniProtKB/Swiss-Prot:O34741" /translation="MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAI NEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFR ILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVF CGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYV SSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEV LSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNE KDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKD VKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTF TSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKN EHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRK LGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYT ALYSIFGFLSVLYYKKVIKSSL*" /label="bceB CDS" gene complement(2531757..2533697) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /label="bceB gene" downshifts complement(2531768) /Source="Nicolas_upshifts" /id="D1565" /incds=0 /nref=13 /ntot=89 /MaxReadThrough="1.56566" /MaxDrop="4.45006" /score="29.4802229" /energy="-11.6" /TU="NA" /idTUdmin="U2356" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2533687..2534448) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14612242, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 17905982, 25118291; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacitracin ABC efflux transporter (ATP-binding protein)" /protein_id="NP_390916.1" /db_xref="EnsemblGenomes-Gn:BSU30380" /db_xref="EnsemblGenomes-Tr:CAB15016" /db_xref="GOA:O34697" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13920" /db_xref="UniProtKB/Swiss-Prot:O34697" /translation="MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGS GKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTV KENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIH DPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKD GQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH*" /label="bceA CDS" gene complement(2533687..2534448) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /label="bceA gene" misc_feature complement(2534472..2534490) /Source="Nicolas_upshift_promotors" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2534491) /Source="Nicolas_upshifts" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2534550..2535554) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA]" /protein_id="NP_390917.1" /db_xref="EnsemblGenomes-Gn:BSU30390" /db_xref="EnsemblGenomes-Tr:CAB15017" /db_xref="GOA:O35044" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13919" /db_xref="UniProtKB/Swiss-Prot:O35044" /translation="MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYL CILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLK QTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLL DQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDA KWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGF TSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV *" /label="bceS CDS" gene complement(2534550..2535554) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /label="bceS gene" downshifts complement(2534589) /Source="Nicolas_upshifts" /id="D1566" /incds=0 /nref=25 /ntot=187 /MaxReadThrough="2.40611" /MaxDrop="4.6482" /score="29.3236847" /energy="-13.9" /TU="NA" /idTUdmin="U2357" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2535547..2536242) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB]" /protein_id="NP_390918.1" /db_xref="EnsemblGenomes-Gn:BSU30400" /db_xref="EnsemblGenomes-Tr:CAB15018" /db_xref="GOA:O34951" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12340" /db_xref="UniProtKB/Swiss-Prot:O34951" /translation="MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAV NPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKP FHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVG QGYIAKEEDKFYD*" /label="bceR CDS" gene complement(2535547..2536242) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /label="bceR gene" promotor_-10 complement(2536266..2536284) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2536278) /Source="Nicolas_upshifts" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2536300..2536303) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2536339..2537649) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="metabolite permease involved in resistance to cell wall inhibitors" /protein_id="NP_390919.1" /db_xref="EnsemblGenomes-Gn:BSU30410" /db_xref="EnsemblGenomes-Tr:CAB15019" /db_xref="GOA:O35005" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13916" /db_xref="UniProtKB/Swiss-Prot:O35005" /translation="MRFKDQVHFIRRNMKKNRLRVFMTILATTMACAFLVVLSSVGFG IQKTITDMTMSQQIVTKVSVMGKEGDKPIKKADLEKYDHVRSVVERTQVYEPNKATLG NRTNESSNLIFTNMNDELKANMELEKGRVAKSENEIVVGYDFAKRLLTKKESEEYNKK IEEAKGNPEDIKEPKGYTKDILNKTIELSVSKTDSKTGDVTKTKTYDFKIVGITKKPS QDWMEDSNIFISDQFKKDFSEFLDFKGGNVETNIGVFADKFENVEQLTNDLTDDGYYV TSVTTELEGANTFFMVFKIGLIFVGCIAVIISAIGIFNTMTMAVTERTQEIGIMKAIG ASPSIIRRMFLMESAYIGILGCVIGIIISYGVSYLVNLAVPMILAATSGGDAGDLNYT FSYIPASLVIIAVVICGGVAVISGMNPARKATKTNVLTALRREL*" /label="ytrF CDS" gene complement(2536339..2537649) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /label="ytrF gene" downshifts complement(2536361) /Source="Nicolas_upshifts" /id="D1567" /incds=0 /nref=9 /ntot=170 /MaxReadThrough="4.26891" /MaxDrop="3.83905" /score="28.2472037" /energy="-13.6" /TU="U2359" /idTUdmin="U2359" /TUdmin="-1755" /isTUend="FALSE" /label="downshifts" CDS complement(2537639..2538334) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22720735, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22720735, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390920.1" /db_xref="EnsemblGenomes-Gn:BSU30420" /db_xref="EnsemblGenomes-Tr:CAB15020" /db_xref="GOA:O34392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13915" /db_xref="UniProtKB/Swiss-Prot:O34392" /translation="MIDVQHIDHSFTIGKKGRENEVPVLKDVSLSVAKGEIACIVGRS GSGKSTLLNLISGYISPTKGRIVINGTDVTGFNEKEWAQFRLDHFGFIFQSFQLIPGL TTYENVEMPLALKGIKPSERKQKVQDMLKRVGLENHAAHYPNELSGGQQQRVSIARAL ILNPSIILADEPTGSLDSETEHEVLELIQQLNRERGITFVIITHDDEVASIGHSKFQL HDGVLKGGITVEV*" /label="ytrE CDS" gene complement(2537639..2538334) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /label="ytrE gene" CDS complement(2538349..2539326) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390921.1" /db_xref="EnsemblGenomes-Gn:BSU30430" /db_xref="EnsemblGenomes-Tr:CAB15021" /db_xref="GOA:O34953" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13914" /db_xref="UniProtKB/Swiss-Prot:O34953" /translation="MPDSGLLYKEWRQNKVALVITILVFILGNPLSILNMYLIYQGCV TGKENWVGPCVFSVDYLNSSFISLFWIWGVVLAVSQLGIERSKSFFDFTLSLPYTRGQ IFHAKFLTGGMVIVVPQLIGYVLSVLLIMLLKPDQAVYFHNYSLGMIIVSMLAYSLVM AGGALTGNSFAQLLVSFTVAISPFLLISLPVINLEILFGGSIDFIHGPVPKWVQYFIP IIYVDSKWAENSPYYLVIPAIMTIIFYIIGYISFVKMSNERNGYFFLWKPLNRPVQII VIIIGIMGFGYFGFTASESFAGYLIGMGTGAVIGFLISYFAIYKKMKLL*" /label="ytrD CDS" gene complement(2538349..2539326) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /label="ytrD gene" CDS complement(2539356..2540342) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390922.1" /db_xref="EnsemblGenomes-Gn:BSU30440" /db_xref="EnsemblGenomes-Tr:CAB15022" /db_xref="GOA:O34898" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13913" /db_xref="UniProtKB/Swiss-Prot:O34898" /translation="MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCL DRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIF QTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAA GALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLS NLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRP VQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV*" /label="ytrC CDS" gene complement(2539356..2540342) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /label="ytrC gene" promotor_-35 2540212..2540221 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2540228 /Source="Nicolas_upshifts" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2540234..2540249 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2540336..2541214) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390923.1" /db_xref="EnsemblGenomes-Gn:BSU30450" /db_xref="EnsemblGenomes-Tr:CAB15023" /db_xref="GOA:O34641" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13912" /db_xref="UniProtKB/Swiss-Prot:O34641" /translation="MIELRQLSKAIDGNQVLKDVSLTIEKGEIFGLLGRNGSGKTTML RLIQQIIFADSGTILFDGVEIKKHPKVKQNIIYMPVQNPFYDKYTYKQLVDILRRIYP KFDVTYANELMNRYEIPETKKYRELSTGLKKQLSLVLSFAARPALILLDEPTDGIDAV TRHDVLQLMVDEVAERDTSILITSHRLEDIERMCNRIGFLEDNSLTNVMDLDELKEEY IKIQMAFDTDVNLAIREQNIPMLDQAGVFYTVLIPKSDEEKKSFLRELKPKVWNELPV NLEEVFIAKFGGKRRW*" /label="ytrB CDS" gene complement(2540336..2541214) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /label="ytrB gene" CDS complement(2541207..2541599) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986249, 11756427, 17194626, 21856850, 28357385" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 11756427, 17194626, 21856850, 28357385; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family, cell wall antibiotics)" /protein_id="NP_390924.1" /db_xref="EnsemblGenomes-Gn:BSU30460" /db_xref="EnsemblGenomes-Tr:CAB15024" /db_xref="GOA:O34712" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13911" /db_xref="UniProtKB/Swiss-Prot:O34712" /translation="MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATI IIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDA HYAGVELEKLHEWIKEISADVKGGKKND*" /label="ytrA CDS" gene complement(2541207..2541599) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /label="ytrA gene" S_feature complement(2541600..2541844) /Source="Nicolas_S_feature" /locus_tag="new_3119240_3119484_c" /HighExp="Cold, Salt, SMMPr, MG 15, M9-tran, G180, M9-exp, M/G, MG 25, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.71885600000000005" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1162" CDS complement(2541633..2541770) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28357385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513999.1" /db_xref="EnsemblGenomes-Gn:BSU30466" /db_xref="EnsemblGenomes-Tr:CCQ48604" /db_xref="GOA:L8ECR1" /db_xref="UniProtKB/TrEMBL:L8ECR1" /translation="MKHKKRNKRNVPMLIAASVIACSFFLVLVMIGFEWQKSIIDHFY L*" /label="conserved protein of unknown function CDS" gene complement(2541633..2541770) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /label="gene" downshifts 2541768 /Source="Nicolas_upshifts" /id="D1568" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.62989" /MaxDrop="3.1332" /score="6.69010243" /energy="-14.4" /TU="NA" /idTUdmin="U2361" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2541839..2541858) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2541844) /Source="Nicolas_upshifts" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2541872..2541879) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2541925..2542197) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390925.1" /db_xref="EnsemblGenomes-Gn:BSU30470" /db_xref="EnsemblGenomes-Tr:CAB15025" /db_xref="InterPro:IPR019668" /db_xref="SubtiList:BG13937" /db_xref="UniProtKB/Swiss-Prot:O32073" /translation="MATRQSVDEHLQQCMQAYDYAEEQLKIASKQEHYNDQEYSDAQM QLEDAVNALNKLWLSSNDQQREQLYRMRLQLQSLQNNMILQHPLDV*" /label="ytzC CDS" gene complement(2541925..2542197) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /label="ytzC gene" downshifts complement(2541932) /Source="Nicolas_upshifts" /id="D1569" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.96566" /MaxDrop="8.4811" /score="36.3100501" /energy="-14.4" /TU="NA" /idTUdmin="U2360" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2542237..2542248) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2542241..2542249 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2542241) /Source="Nicolas_upshifts" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="upshifts" upshifts 2542252 /Source="Nicolas_upshifts" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2542263..2542269) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2542263..2542281 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2542292..2542297 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2542311..2542330 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2542318 /Source="Nicolas_upshifts" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="upshifts" CDS 2542359..2543327 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10413665; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_390926.1" /db_xref="EnsemblGenomes-Gn:BSU30480" /db_xref="EnsemblGenomes-Tr:CAB15026" /db_xref="GOA:O35008" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032432" /db_xref="SubtiList:BG13908" /db_xref="UniProtKB/Swiss-Prot:O35008" /translation="MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPN RDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTN THAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQT VHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADL DVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGD GPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL*" /label="ytqA CDS" gene 2542359..2543327 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /label="ytqA gene" CDS 2543324..2543908 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24699744; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methylase" /protein_id="NP_390927.1" /db_xref="EnsemblGenomes-Gn:BSU30490" /db_xref="EnsemblGenomes-Tr:CAB15027" /db_xref="GOA:O34614" /db_xref="InterPro:IPR010719" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13909" /db_xref="UniProtKB/Swiss-Prot:O34614" /translation="MILKKILPYSKELLKMAAGEGDIVVDATMGNGHDTQFLAELVGE NGHVYAFDIQESAVANTKERLGDMYQARTTLFHKSHDKIAESLPPETHGKVAAAVFNL GYLPGGDKSITTNGSSTIKAIEQLLSIMKDEGLIVLVVYHGHPEGKAEKNDVLEFCRD LDQQTARVLTYGFINQQNDPPFIVAIEKKAQISK*" /label="ytqB CDS" gene 2543324..2543908 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /label="ytqB gene" downshifts 2543872 /Source="Nicolas_upshifts" /id="D1570" /incds=0 /nref=58 /ntot=249 /MaxReadThrough="2.35311" /MaxDrop="4.47418" /score="22.0352465" /energy="-11.9" /TU="NA" /idTUdmin="U2362" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2543898..>2544029) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /EC_number="4.2.3.130" /experiment="publication(s) with functional evidences, PMID:21627333, 24806199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21627333, 24806199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetraprenyl-beta-curcumene synthase" /protein_id="NP_390928.1" /db_xref="EnsemblGenomes-Gn:BSU30500" /db_xref="EnsemblGenomes-Tr:CAB15028" /db_xref="GOA:O34707" /db_xref="InterPro:IPR019712" /db_xref="SubtiList:BG13901" /db_xref="UniProtKB/Swiss-Prot:O34707" /modified_by="User" /translation="LAKKLIKASGKTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC* " /label="IIG_Bs13_pseudo_BSU_30500" gene complement(2543898..>2544029) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /modified_by="User" /label="IIG_Bs13_pseudo_BSU_30500" downshifts complement(2543939) /Source="Nicolas_upshifts" /id="D1571" /incds=0 /nref=35 /ntot=240 /MaxReadThrough="3.47268" /MaxDrop="4.45295" /score="16.7564664" /energy="-10.1" /TU="U2364" /idTUdmin="U2365" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR 2544032..2544033 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs13" S_feature complement(<2544033..2544048) /Source="Nicolas_S_feature" /locus_tag="new_3123442_3124021_c" /HighExp="dia15, H2O2, Diami, Salt, dia5, M0t90, Lbstat, Etha, Paraq, Lbtran" /AntisenseName="ytoA" /AntisenseCor="-0.44861767737485803" /AntisenseRegPval="-14" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1163" promotor_-10 complement(2544039..2544058) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2544048) /Source="Nicolas_upshifts" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2544050..2544184) /Source="Nicolas_S_feature" /locus_tag="new_3124023_3124157_c" /HighExp="LoTm, Cold, dia5, dia15, Diami, H2O2, S7, G135, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1164" promotor_-35 complement(2544070..2544077) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2544159..2544178) /Source="Nicolas_upshift_promotors" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2544184) /Source="Nicolas_upshifts" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2544277..2545668) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_390931.1" /db_xref="EnsemblGenomes-Gn:BSU30530" /db_xref="EnsemblGenomes-Tr:CAB15031" /db_xref="GOA:O34618" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG13891" /db_xref="UniProtKB/Swiss-Prot:O34618" /translation="MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPG ILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVV TCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEM IGVTAGEVKNPQKSLAKAIDTVFWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQ KVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGK AVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEK KQLKYKMPLFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFH KKNAAAASERNIS*" /label="ytnA CDS" gene complement(2544277..2545668) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /label="ytnA gene" downshifts complement(2544285) /Source="Nicolas_upshifts" /id="D1572" /incds=0 /nref=133 /ntot=225 /MaxReadThrough="3.05784" /MaxDrop="5.43778" /score="3.82664462" /energy="-7.5" /TU="U2368" /idTUdmin="U2368" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(2545669..2545803) /Source="Nicolas_S_feature" /locus_tag="new_3125642_3125776_c" /HighExp="Oxctl, Paraq, Heat, Lbexp, G150, S0, dia0, H2O2, G180, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1165" CDS complement(2545804..2547702) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /EC_number="2.4.-.-" /EC_number="6.3.5.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 21949063, 28317238" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 21949063, 28317238; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-diaminopimelic acid amidotransferase (asparagine synthetase)" /protein_id="NP_390932.1" /db_xref="EnsemblGenomes-Gn:BSU30540" /db_xref="EnsemblGenomes-Tr:CAB15032" /db_xref="GOA:P54420" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11831" /db_xref="UniProtKB/Swiss-Prot:P54420" /translation="MCGFVGVFNKHPLAQTADQEELIKQMNQMIVHRGPDSDGYFHDE HVGFGFRRLSIIDVENGGQPLSYEDETYWIIFNGEIYNYIELREELEAKGYTFNTDSD TEVLLATYRHYKEEAASKLRGMFAFLIWNKNDHVLYGARDPFGIKPLYYTTINDQVYF ASERKSLMVAQNDIEIDKEALQQYMSFQFVPEPSTLDAHVKKVEPGSQFTIRPDGDIT FKTYFKANFKPVQTEEDKLVKEVRDAIYDSVNVHMRSDVPVGSFLSGGIDSSFIVSVA KEFHPSLKTFSVGFEQQGFSEVDVAKETAAALGIENISKVISPEEYMNELPKIVWHFD DPLADPAAIPLYFVAKEAKKHVTVALSGEGADELFGGYNIYREPLSLKPFERIPSGLK KMLLHVAAVMPEGMRGKSLLERGCTPLQDRYIGNAKIFEESVKKQLLKHYNPNLSYRD VTKTYFTESSSYSDINKMQYVDIHTWMRGDILLKADKMTMANSLELRVPFLDKVVFDV ASKIPDELKTKNGTTKYLLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKNEMNEWVRNI IQESQTDAYIHKDYVLQLLEDHCADKADNSRKIWTVLIFMIWHSINIEKRYMPEELSH QPKEVIFV*" /label="asnB CDS" gene complement(2545804..2547702) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /label="asnB gene" promotor_-35 2546860..2546866 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2546881..2546892 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2546893 /Source="Nicolas_upshifts" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2547703..2547826) /Source="Nicolas_S_feature" /locus_tag="new_3127676_3127799_c" /HighExp="Paraq, G135, G180, G150, Oxctl, LBGexp, BMM, dia0, Heat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.632, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1166" CDS complement(2547852..2549054) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /EC_number="2.5.1.6" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16672621, 18634909" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16672621, 18634909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="NP_390933.1" /db_xref="EnsemblGenomes-Gn:BSU30550" /db_xref="EnsemblGenomes-Tr:CAB15033" /db_xref="GOA:P54419" /db_xref="InterPro:IPR002133" /db_xref="InterPro:IPR022628" /db_xref="InterPro:IPR022629" /db_xref="InterPro:IPR022630" /db_xref="InterPro:IPR022631" /db_xref="InterPro:IPR022636" /db_xref="SubtiList:BG11840" /db_xref="UniProtKB/Swiss-Prot:P54419" /translation="MSKNRRLFTSESVTEGHPDKICDQISDSILDEILKKDPNARVAC ETSVTTGLVLVSGEITTSTYVDIPKTVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQS ADIAMGVDQALEAREGTMSDEEIEAIGAGDQGLMFGYACNETKELMPLPISLAHKLAR RLSEVRKEDILPYLRPDGKTQVTVEYDENNKPVRIDAIVISTQHHPEITLEQIQRNIK EHVINPVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGA FSGKDATKVDRSAAYAARYVAKNIVAAELADSCEVQLAYAIGVAQPVSISINTFGSGK ASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDVDLPWERTDKAEQ LRKEALGE*" /label="metK CDS" gene complement(2547852..2549054) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /label="metK gene" downshifts complement(2547871) /Source="Nicolas_upshifts" /id="D1573" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="7.14538" /MaxDrop="3.78097" /score="-4.044113" /energy="-12.1" /TU="U2367,U2368" /idTUdmin="U2367" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2549097..2549108) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2549103) /Source="Nicolas_upshifts" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2549105..2549221) /Source="Nicolas_S_feature" /locus_tag="new_3129078_3129194_c" /HighExp="G180, Paraq, G150, Oxctl, G135, BMM, LBGexp, HPh, MG-0.2, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1167" promotor_-35 complement(2549122..2549128) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2549222..2549360) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswG RNA" gene complement(2549222..2549360) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /label="mswG gene" downshifts 2549320 /Source="Nicolas_upshifts" /id="D1574" /incds=0 /nref=3 /ntot=20 /MaxReadThrough="1.15866" /MaxDrop="4.97875" /score="11.8729615" /energy="-16.6" /TU="NA" /idTUdmin="U2369" /TUdmin="-1841" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2549369..2549388) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-10" upshifts complement(2549384) /Source="Nicolas_upshifts" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="upshifts" promotor_-35 complement(2549405..2549409) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-35" promotor_-35 2549481..2549488 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2549500 /Source="Nicolas_upshifts" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2549502..2549521 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2549557..2551140 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /EC_number="4.1.1.49" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400158, 4146915, 15491857, 15720552, 18586936, 20933603, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoenolpyruvate carboxykinase" /protein_id="NP_390934.2" /db_xref="EnsemblGenomes-Gn:BSU30560" /db_xref="EnsemblGenomes-Tr:CAB15034" /db_xref="GOA:P54418" /db_xref="InterPro:IPR001272" /db_xref="InterPro:IPR008210" /db_xref="InterPro:IPR013035" /db_xref="InterPro:IPR015994" /db_xref="SubtiList:BG11841" /db_xref="UniProtKB/Swiss-Prot:P54418" /translation="MNSVDLTADLQALLTCPNVRHNLSAAQLTEKVLSRNEGILTSTG AVRATTGAYTGRSPKDKFIVEEESTKNKIDWGPVNQPISEEAFERLYTKVVSYLKERD ELFVFEGFAGADEKYRLPITVVNEFAWHNLFARQLFIRPEGNDKKTVEQPFTILSAPH FKADPKTDGTHSETFIIVSFEKRTILIGGTEYAGEMKKSIFSIMNFLLPERDILSMHC SANVGEKGDVALFFGLSGTGKTTLSADADRKLIGDDEHGWSDTGVFNIEGGCYAKCIH LSEEKEPQIFNAIRFGSVLENVVVDEDTREANYDDSFYTENTRAAYPIHMINNIVTPS MAGHPSAIVFLTADAFGVLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTSPETTFST CFGSPFLPLPAHVYAEMLGKKIDEHGADVFLVNTGWTGGGYGTGERMKLSYTRAMVKA AIEGKLEDAEMITDDIFGLHIPAHVPGVPDHILQPENTWTNKEEYKEKAVYLANEFKE NFKKFAHTDAIAQAGGPLV*" /label="pckA CDS" gene 2549557..2551140 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /label="pckA gene" downshifts 2551129 /Source="Nicolas_upshifts" /id="D1575" /incds=0 /nref=106 /ntot=269 /MaxReadThrough="2.55056" /MaxDrop="8.3695" /score="11.8729615" /energy="-16.6" /TU="U2369" /idTUdmin="U2369" /TUdmin="-32" /isTUend="FALSE" /label="downshifts" CDS complement(2551179..2551421) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390935.1" /db_xref="EnsemblGenomes-Gn:BSU30570" /db_xref="EnsemblGenomes-Tr:CAB15035" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019699" /db_xref="PDB:2NWA" /db_xref="SubtiList:BG13882" /db_xref="UniProtKB/Swiss-Prot:O34365" /translation="MGMPVEFNTLIVTKGKEVRIDENIFTLEKDGYRVYPMEIPMDVR KTKFGEKSGTAEVQKLQWEEGRTIITYKLTSLHSVN*" /label="ytmB CDS" gene complement(2551179..2551421) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /label="ytmB gene" downshifts complement(2551193) /Source="Nicolas_upshifts" /id="D1576" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="1.2088" /MaxDrop="5.1365" /score="38.3436505" /energy="-16.6" /TU="NA" /idTUdmin="U2371" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2551473..2552246) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27899916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="NP_390936.1" /db_xref="EnsemblGenomes-Gn:BSU30580" /db_xref="EnsemblGenomes-Tr:CAB15036" /db_xref="GOA:O34493" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13881" /db_xref="UniProtKB/Swiss-Prot:O34493" /translation="MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDG FLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAF RLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQD LRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEK LKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR*" /label="ytmA CDS" gene complement(2551473..2552246) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /label="ytmA gene" S_feature complement(2552247..2552337) /Source="Nicolas_S_feature" /locus_tag="new_3132220_3132310_c" /HighExp="S8, dia15, Diami, Etha, S7, dia5, H2O2, G180, Heat, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1168" promotor_-35 2552313..2552322 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2552326..2552345) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2552334 /Source="Nicolas_upshifts" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2552335..2552354 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2552339) /Source="Nicolas_upshifts" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2552360..2552367) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2552397..2553401 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component" /protein_id="NP_390937.2" /db_xref="EnsemblGenomes-Gn:BSU30595" /db_xref="EnsemblGenomes-Tr:CAB15037" /db_xref="GOA:C0SP84" /db_xref="SubtiList:BG13873" /db_xref="UniProtKB/Swiss-Prot:C0SP84" /translation="MNRWLRLGFACVGSIFLMFALAACKQEETLTKVKVAEVTHSIFY APLYVAESKGFFKEEGLDVDVNTTWGGDKTMTSLLSNGSDIALVGSETSIYVEAQGAK DPVINFAQLTQTDGTFLVAREDVEHFDWDQLKGKTFLGQRKGGMPQMVGEYVLNKHKI DPHKDIDLIQNIDFANIANAFASGTGEYVQLFEPQASLFEKKGIGHIVASFGEESGEV PYTTFMAKQSYLKKNEDTAVKFTKAIYKAQQWVENHSAKDITDAIKDEFDDTDPDVIE TSIERYKKQHSYSPDPLLNEKEWELLQTIMDKSGELPKHIPYNQLVNKEIAEKVTSEK *" /label="ytlA CDS" gene 2552397..2553401 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /label="ytlA gene" CDS 2553414..2554196 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component, ATP-binding" /protein_id="NP_390939.1" /db_xref="EnsemblGenomes-Gn:BSU30610" /db_xref="EnsemblGenomes-Tr:CAB15039" /db_xref="GOA:O34314" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13875" /db_xref="UniProtKB/Swiss-Prot:O34314" /translation="MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGC GKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLK IADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDE PFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQI FTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH*" /label="ytlC CDS" gene 2553414..2554196 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /label="ytlC gene" S_feature complement(2553418..2554966) /Source="Nicolas_S_feature" /locus_tag="new_3133391_3134939_c" /HighExp="Cold, S8, G180, H2O2, G135, Paraq, G150, S7, Oxctl, LPh" /AntisenseName="ytlC" /AntisenseCor="0.110169300738282" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1169" CDS 2554171..2554983 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease of ABC anion transporter" /protein_id="NP_390940.1" /db_xref="EnsemblGenomes-Gn:BSU30620" /db_xref="EnsemblGenomes-Tr:CAB15040" /db_xref="GOA:O34649" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13876" /db_xref="UniProtKB/Swiss-Prot:O34649" /translation="MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEIS SRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAAL LWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVY TAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFL VSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT*" /label="ytlD CDS" gene 2554171..2554983 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /label="ytlD gene" downshifts 2554968 /Source="Nicolas_upshifts" /id="D1577" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="3.58734" /MaxDrop="4.596" /score="38.1379668" /energy="-12.6" /TU="U2370" /idTUdmin="U2370" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(2555010..2555486) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /EC_number="3.6.1.15" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576788, 16513759, 21925382, 23610407, 23610425, 27936487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576788, 16513759, 21925382, 23610407, 23610425, 27936487; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nucleoside and RNA triphosphate phosphohydrolase" /protein_id="NP_390941.1" /db_xref="EnsemblGenomes-Gn:BSU30630" /db_xref="EnsemblGenomes-Tr:CAB15041" /db_xref="GOA:O35013" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR014078" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="PDB:4JZS" /db_xref="PDB:4JZT" /db_xref="PDB:4JZU" /db_xref="PDB:4JZV" /db_xref="SubtiList:BG13869" /db_xref="UniProtKB/Swiss-Prot:O35013" /translation="MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHE DRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFA DIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE*" /label="rppG CDS" gene complement(2555010..2555486) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /label="rppG gene" downshifts complement(2555011) /Source="Nicolas_upshifts" /id="D1578" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.52721" /MaxDrop="6.99686" /score="36.2618206" /energy="-12.6" /TU="U2372" /idTUdmin="U2373" /TUdmin=11 /isTUend="TRUE" /label="downshifts" misc_feature complement(2555516..2555535) /Source="Nicolas_upshift_promotors" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2555529) /Source="Nicolas_upshifts" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2555531..2555665) /Source="Nicolas_S_feature" /locus_tag="new_3135504_3135638_c" /HighExp="BT, B36, S8, S5, S7, Etha, S6, S4, B60, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK, SigB" /TUshortPSig="0.909, 1, 0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1170" upshifts complement(2555665) /Source="Nicolas_upshifts" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2555667..2555678) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2555693..2555699) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2555695..2556099) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative autolytic amidase" /protein_id="NP_390942.1" /db_xref="EnsemblGenomes-Gn:BSU30640" /db_xref="EnsemblGenomes-Tr:CAB15042" /db_xref="GOA:O34883" /db_xref="InterPro:IPR006480" /db_xref="SubtiList:BG13868" /db_xref="UniProtKB/Swiss-Prot:O34883" /translation="MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTT LKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESV QIVVTASSLGIPVPQMLVDLLETLKNKFKRKP*" /label="ytkC CDS" gene complement(2555695..2556099) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /label="ytkC gene" promotor_-10 complement(2556127..2556146) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2556144) /Source="Nicolas_upshifts" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2556146..2556232) /Source="Nicolas_S_feature" /locus_tag="new_3136119_3136205_c" /HighExp="Etha, B36, S8, B60, S7, LoTm, Salt, Sw, Gly, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1171" promotor_-35 complement(2556159..2556168) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2556265..2556702) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12767829, 16091047, 16861227, 16935006; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-protecting protein, mini-ferritin" /protein_id="NP_390943.1" /db_xref="EnsemblGenomes-Gn:BSU30650" /db_xref="EnsemblGenomes-Tr:CAB15043" /db_xref="GOA:P80879" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="SubtiList:BG12584" /db_xref="UniProtKB/Swiss-Prot:P80879" /translation="MSEQLIQAVNKQVANWTVMYVKLHNYHWYVKGKDFFTLHEKFEE LYNETATYIDDLAERLLALNGKPIATMKESLETASVKEAAGNETAEQMVQSVYDDFTV IAEELKNGMDLADEVGDETTGDMLLAIHQNIEKHNWMLKAYLG*" /label="dps CDS" gene complement(2556265..2556702) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /label="dps gene" downshifts complement(2556277) /Source="Nicolas_upshifts" /id="D1579" /incds=0 /nref=188 /ntot=382 /MaxReadThrough="3.87056" /MaxDrop="7.83664" /score="36.0931083" /energy="-19.2" /TU="U2375" /idTUdmin="U2377" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2556719..2556737) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2556737) /Source="Nicolas_upshifts" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2556739..2556964) /Source="Nicolas_S_feature" /locus_tag="new_3136712_3136937_c" /HighExp="M0t90, Lbstat, M40t90, ferm, S2, nit, M40t45, S0, Lbtran, BT" /AntisenseName="ytzI" /AntisenseCor="-0.30531150128448598" /AntisenseRegPval="-6.5" /CDS_PredictionProba="0.38276900000000003" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1172" promotor_-35 complement(2556752..2556758) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2556794..2556813 /Source="Nicolas_upshift_promotors" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2556795..2556971 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097774.1" /db_xref="EnsemblGenomes-Gn:BSU30659" /db_xref="EnsemblGenomes-Tr:CAX52680" /db_xref="GOA:C0H3Q1" /db_xref="InterPro:IPR022248" /db_xref="UniProtKB/Swiss-Prot:C0H3Q1" /translation="MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHT IDPPQENHSDSHNQ*" /label="ytzI CDS" gene 2556795..2556971 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /label="ytzI gene" upshifts 2556796 /Source="Nicolas_upshifts" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2556965..2557402) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390944.1" /db_xref="EnsemblGenomes-Gn:BSU30660" /db_xref="EnsemblGenomes-Tr:CAB15044" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR032693" /db_xref="SubtiList:BG11027" /db_xref="UniProtKB/Swiss-Prot:P40768" /translation="MKKMLVVLLFSALLLNGCGSGESKANTAETPEVLDVKLTGPEKV NPGESAAYEAAVSYGDEAVTDADEVEFEVWKEGEKDASQMFKVKQEKGVYRLETTFKE DGVYTVQSHVTAKKQHSMPTLKVQVGDADAASNQSEEEHSHHH*" /label="ytkA CDS" gene complement(2556965..2557402) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /label="ytkA gene" downshifts 2556991 /Source="Nicolas_upshifts" /id="D1580" /incds=0 /nref=37 /ntot=155 /MaxReadThrough="2.0116" /MaxDrop="3.95427" /score="13.1411485" /energy="-20.5" /TU="NA" /idTUdmin="U2376" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2557421..2557440) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-10" upshifts complement(2557442) /Source="Nicolas_upshifts" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 complement(2557451..2557459) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-35" CDS complement(2557522..2557995) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /EC_number="4.4.1.21" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-ribosylhomocysteine lyase" /protein_id="NP_390945.1" /db_xref="EnsemblGenomes-Gn:BSU30670" /db_xref="EnsemblGenomes-Tr:CAB15045" /db_xref="GOA:O34667" /db_xref="InterPro:IPR003815" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR037005" /db_xref="PDB:1IE0" /db_xref="PDB:1J98" /db_xref="PDB:1JQW" /db_xref="PDB:1JVI" /db_xref="PDB:1YCL" /db_xref="PDB:2FQO" /db_xref="PDB:2FQT" /db_xref="SubtiList:BG13866" /db_xref="UniProtKB/Swiss-Prot:O34667" /translation="MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPN KQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIV DLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG*" /label="luxS CDS" gene complement(2557522..2557995) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /label="luxS gene" downshifts complement(2557531) /Source="Nicolas_upshifts" /id="D1581" /incds=0 /nref=72 /ntot=201 /MaxReadThrough="4.53626" /MaxDrop="4.63695" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-793" /isTUend="FALSE" /label="downshifts" downshifts complement(2557618) /Source="Nicolas_upshifts" /id="D1582" /incds=1 /nref=1 /ntot=96 /MaxReadThrough="5.57623" /MaxDrop="2.4806" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" S_feature complement(2557996..2558347) /Source="Nicolas_S_feature" /locus_tag="new_3137969_3138320_c" /HighExp="Etha, B36, B60, BMM, S2, Heat, S1, LoTm, Lbtran, S5" /AntisenseName="ytjA" /AntisenseCor="-0.45038987072908898" /AntisenseRegPval="-14.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1173" promotor_-35 2558067..2558074 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2558087..2558106 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2558092 /Source="Nicolas_upshifts" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2558124..2558351 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19306042, 21803992; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein insertion efficiency factor" /protein_id="NP_390946.1" /db_xref="EnsemblGenomes-Gn:BSU30680" /db_xref="EnsemblGenomes-Tr:CAB15046" /db_xref="GOA:O34601" /db_xref="InterPro:IPR002696" /db_xref="SubtiList:BG13865" /db_xref="UniProtKB/Swiss-Prot:O34601" /translation="MKTLFIALIRGYQKFISPLTPPTCRFYPTCSQYGIEAIKTHGAL KGGWLTIKRILKCHPFHPGGVDPVPEKKQKH*" /label="ytjA CDS" gene 2558124..2558351 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /label="ytjA gene" CDS complement(2558348..2558911) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /EC_number="4.2.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12193617, 21266987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carbonic anhydrase" /protein_id="NP_390947.1" /db_xref="EnsemblGenomes-Gn:BSU30690" /db_xref="EnsemblGenomes-Tr:CAB15047" /db_xref="GOA:O34872" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG13863" /db_xref="UniProtKB/Swiss-Prot:O34872" /translation="MSLLNDILEFNKTFTEQREYEKYQTSKFPDKKMAILSCMDTRLV ELLPHAMNLRNGDVKIIKSAGALVTHPFGSIMRSILVAVYELNADEVCVIGHHDCGMS KISSKSMLEKIKARGIPEERIETIKYSGVDFDQWFKSFDSVEASVKDSVDVIKHHPLF PENVPVHGLVIDPKTGKLDLIVNGYNN*" /label="ytiB CDS" gene complement(2558348..2558911) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /label="ytiB gene" misc_feature complement(2558936..2558955) /Source="Nicolas_upshift_promotors" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2558951) /Source="Nicolas_upshifts" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2559005..2559253) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15049826, 16014871, 16547061, 19648245, 20208344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15049826, 16014871, 16547061, 19648245, 20208344; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_390948.1" /db_xref="EnsemblGenomes-Gn:BSU30700" /db_xref="EnsemblGenomes-Tr:CAB15048" /db_xref="GOA:O34967" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027493" /db_xref="InterPro:IPR034704" /db_xref="SubtiList:BG13862" /db_xref="UniProtKB/Swiss-Prot:O34967" /translation="MKEGIHPKNHKVIFQDVNSGYRFLSTSTKTSNETAEWEDGNTYP VIKVEVSSDTHPFYTGRQKFNEKGGRVEQFKKRYNMGK*" /label="rpmEB CDS" gene complement(2559005..2559253) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /label="rpmEB gene" downshifts complement(2559026) /Source="Nicolas_upshifts" /id="D1583" /incds=0 /nref=96 /ntot=217 /MaxReadThrough="7.96356" /MaxDrop="4.50701" /score="15.8096104" /energy="-7.5" /TU="U2380" /idTUdmin="U2380" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2559281..2559300) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-10" promotor_-35 complement(2559314..2559321) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-35" upshifts complement(2559318) /Source="Nicolas_upshifts" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 2559380..2559386 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-35" promotor_-10 2559400..2559411 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-10" upshifts 2559412 /Source="Nicolas_upshifts" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="upshifts" CDS 2559458..2560789 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9852001, 10551842, 15849754, 16850406, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit I" /protein_id="NP_390949.2" /db_xref="EnsemblGenomes-Gn:BSU30710" /db_xref="EnsemblGenomes-Tr:CAB15049" /db_xref="GOA:C0SP90" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG13857" /db_xref="UniProtKB/Swiss-Prot:C0SP90" /translation="MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKD DHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAF FVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNG KITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRK ALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDP NEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLI LYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLK TSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES*" /label="ythA CDS" gene 2559458..2560789 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /label="ythA gene" CDS 2560833..2561873 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11073895, 15576792, 15849754, 16850406, 10551842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit II" /protein_id="NP_390950.1" /db_xref="EnsemblGenomes-Gn:BSU30720" /db_xref="EnsemblGenomes-Tr:CAB15050" /db_xref="GOA:O34505" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG13858" /db_xref="UniProtKB/Swiss-Prot:O34505" /translation="MEISTDALIAISIIWGFVFIYAVMATMDFGAGFWSMIYLNKEHM KATDIANRFLSPTWEVTNVFIVAIVVALFSFFPGATFVLGTVLLIPGSMILLLLAIRS GFLVFSNTAKERKTLRYISGISGFIIPAILILVLPVTHGGFIEKTDGIYNLNMSKIFS SPNAYSFIGFAILSTLFLSSLLLADFSNVAEEQDAYRAYRKSALITGPISLLFAVCIM VTMRNEANWLYSGMMNDFSWIIASFITFVIAGIALFLPNKSFGQNIGKPRLALVAIGI QYFLASYAYGRAHLPYMIYPDVTVMSGFTEPATFRALFATYIVAFIILFPGFFFFWKM FMRDKRYIRQEE*" /label="ythB CDS" gene 2560833..2561873 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /label="ythB gene" promotor_-35 2561867..2561873 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2561888..2561899 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2561898 /Source="Nicolas_upshifts" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="upshifts" CDS 2561927..2562085 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097775.1" /db_xref="EnsemblGenomes-Gn:BSU30739" /db_xref="EnsemblGenomes-Tr:CAX52681" /db_xref="InterPro:IPR011437" /db_xref="UniProtKB/Swiss-Prot:C0H3Q2" /translation="MEQKILCEVNNCSYWGKGNKCTADAIYVVSHTGETAENSRETDC KTFKPHDL*" /label="ytzL CDS" gene 2561927..2562085 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /label="ytzL gene" downshifts 2562074 /Source="Nicolas_upshifts" /id="D1584" /incds=0 /nref=55 /ntot=88 /MaxReadThrough="1.7679" /MaxDrop="7.01398" /score="-5.86934022" /energy="-7" /TU="NA" /idTUdmin="U2382" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2562104..2562991) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390952.1" /db_xref="EnsemblGenomes-Gn:BSU30740" /db_xref="EnsemblGenomes-Tr:CAB15052" /db_xref="GOA:O34500" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG13854" /db_xref="UniProtKB/Swiss-Prot:O34500" /translation="MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLG IVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVI LLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVC YKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAA AHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPA NGVITKKLRTLNMQKERAG*" /label="mntD CDS" gene complement(2562104..2562991) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /label="mntD gene" downshifts complement(2562127) /Source="Nicolas_upshifts" /id="D1585" /incds=0 /nref=121 /ntot=218 /MaxReadThrough="3.39755" /MaxDrop="6.80546" /score="-8.37820006" /energy="-7" /TU="U2385" /idTUdmin="U2385" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" CDS complement(2562981..2564288) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390953.1" /db_xref="EnsemblGenomes-Gn:BSU30750" /db_xref="EnsemblGenomes-Tr:CAB15053" /db_xref="GOA:O35024" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13853" /db_xref="UniProtKB/Swiss-Prot:O35024" /translation="MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIG DAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGI VLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCI VFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPA ITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMIC APKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLK ALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDY FDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF*" /label="mntC CDS" gene complement(2562981..2564288) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /label="mntC gene" CDS complement(2564294..2565046) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type t: transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (ATP-binding protein)" /protein_id="NP_390954.1" /db_xref="EnsemblGenomes-Gn:BSU30760" /db_xref="EnsemblGenomes-Tr:CAB15054" /db_xref="GOA:O34338" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13852" /db_xref="UniProtKB/Swiss-Prot:O34338" /translation="MFPVELDNVTVAYHKKPVLQDISLQVPEGKLIGIIGPNGAGKST LIKTILGLVPRASGDISIYGKDYKDQRTRIGYVPQRGSVDWDFPTSPLDVVLMGRYGR IGLLKRPKKADVEMAKAALTKVGMHDYAKRQISQLSGGQQQRVFLARALCQNADIYFM DEPFAGVDAATERAIMTLLAELKEKGKTVLVVHHDLQTAEDYFDWILLLHLRKIAFGP TENVFTIENLQKTYGGRLTFLKDKVLAEGHKE*" /label="mntB CDS" gene complement(2564294..2565046) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /label="mntB gene" CDS complement(2565065..2565985) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (manganese binding lipoprotein)" /protein_id="NP_390955.1" /db_xref="EnsemblGenomes-Gn:BSU30770" /db_xref="EnsemblGenomes-Tr:CAB15055" /db_xref="GOA:O34385" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="SubtiList:BG13851" /db_xref="UniProtKB/Swiss-Prot:O34385" /translation="MRQGLMAAVLFATFALTGCGTDSAGKSADQQLQVTATTSQIADA AENIGGKHVKVTSLMGPGVDPHLYKASQGDTKKLMSADVVLYSGLHLEGKMEDVLQKI GEQKQSAAVAEAIPKNKLIPAGEGKTFDPHVWFSIPLWIYAVDEIEAQFSKAMPQHAD AFRKNAKEYKEDLQYLDKWSRKEIAHIPEKSRVLVTAHDAFAYFGNEYGFKVKGLQGL STDSDYGLRDVQELVDLLTEKQIKAVFVESSVSEKSINAVVEGAKEKGHTVTIGGQLY SDAMGEKGTKEGTYEGMFRHNINTITKALK*" /label="mntA CDS" gene complement(2565065..2565985) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /label="mntA gene" promotor_-10 complement(2566021..2566032) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2566022) /Source="Nicolas_upshifts" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2566024..2566115) /Source="Nicolas_S_feature" /locus_tag="new_3145997_3146088_c" /HighExp="T-0.40H, Sw, T-1.40H, BC, C90, C30, BI, T0.0H, T-3.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.985, 0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1174" promotor_-35 complement(2566046..2566052) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2566100 /Source="Nicolas_upshifts" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2566101..2566120) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2566103..2566115 /Source="Nicolas_upshift_promotors" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2566115) /Source="Nicolas_upshifts" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2566117..2566198) /Source="Nicolas_S_feature" /locus_tag="new_3146090_3146171_c" /HighExp="T1.30H, T1.0H, C30, T0.30H, T2.0H, T2.30H, T-0.40H, T-1.40H, T-2.40H, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1175" promotor_-35 complement(2566135..2566142) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2566198) /Source="Nicolas_upshifts" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="upshifts" promotor_-10 complement(2566207..2566226) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-10" promotor_-35 complement(2566240..2566247) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-35" CDS complement(2566265..2567380) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /EC_number="4.2.1.113" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoate-CoA synthase" /protein_id="NP_390956.1" /db_xref="EnsemblGenomes-Gn:BSU30780" /db_xref="EnsemblGenomes-Tr:CAB15056" /db_xref="GOA:O34514" /db_xref="InterPro:IPR010197" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG13847" /db_xref="UniProtKB/Swiss-Prot:O34514" /translation="MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVT GWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAK AGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQR IKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQ ADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKI HDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIR IDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG*" /label="menC CDS" gene complement(2566265..2567380) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /label="menC gene" downshifts complement(2566308) /Source="Nicolas_upshifts" /id="D1586" /incds=0 /nref=12 /ntot=179 /MaxReadThrough="3.8638" /MaxDrop="2.96378" /score="29.7201414" /energy="-11.1" /TU="U2387,U2388" /idTUdmin="U2388" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2567377..2568837) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /EC_number="6.2.1.26" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299, 28559280" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoic acid-CoA ligase" /protein_id="NP_390957.1" /db_xref="EnsemblGenomes-Gn:BSU30790" /db_xref="EnsemblGenomes-Tr:CAB15057" /db_xref="GOA:P23971" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010192" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:5BUQ" /db_xref="PDB:5BUR" /db_xref="PDB:5BUS" /db_xref="PDB:5GTD" /db_xref="PDB:5X8F" /db_xref="PDB:5X8G" /db_xref="SubtiList:BG10687" /db_xref="UniProtKB/Swiss-Prot:P23971" /translation="MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQ LAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSG FLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPK GVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQR FSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECR EKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHG EIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGE NIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLA KYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL*" /label="menE CDS" gene complement(2567377..2568837) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /label="menE gene" promotor_-10 complement(2568280..2568298) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2568284) /Source="Nicolas_upshifts" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2568313..2568319) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2568926) /Source="Nicolas_upshifts" /id="D1587" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="4.92536" /MaxDrop="2.4145" /score="1.01127104" /energy="-10.8" /TU="U2388" /idTUdmin="U2389" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS complement(2568928..2569743) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /EC_number="4.1.3.36" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxynapthoic acid synthetase" /protein_id="NP_390958.1" /db_xref="EnsemblGenomes-Gn:BSU30800" /db_xref="EnsemblGenomes-Tr:CAB15058" /db_xref="GOA:P23966" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR010198" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG10686" /db_xref="UniProtKB/Swiss-Prot:P23966" /translation="MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMI DAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIR VIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFL KAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP*" /label="menB CDS" gene complement(2568928..2569743) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /label="menB gene" CDS complement(2569778..2570602) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /EC_number="4.2.99.20" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12454479, 23637813; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase" /protein_id="NP_390959.1" /db_xref="EnsemblGenomes-Gn:BSU30810" /db_xref="EnsemblGenomes-Tr:CAB15059" /db_xref="GOA:P23974" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR022485" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10685" /db_xref="UniProtKB/Swiss-Prot:P23974" /translation="MGTVNITVSDGVRYAVADEGPNASEAVVCLHGFTGSKQSWTFLD EMLPDSRLIKIDCLGHGETDAPLNGKRYSTTRQVSDLAEIFDQLKLHKVKLIGYSMGG RLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYW ENIPLFSSQQRLAEDIRYRIRSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEEIDVPV LLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQPRLFGKIVSEFLTSI*" /label="menH CDS" gene complement(2569778..2570602) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /label="menH gene" promotor_-10 complement(2569860..2569879) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2569860) /Source="Nicolas_upshifts" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2569895..2569898) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2570026) /Source="Nicolas_upshifts" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2570036..2570047) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2570062..2570068) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2570590..2572332) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /EC_number="2.2.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase" /protein_id="NP_390960.1" /db_xref="EnsemblGenomes-Gn:BSU30820" /db_xref="EnsemblGenomes-Tr:CAB15060" /db_xref="GOA:P23970" /db_xref="InterPro:IPR004433" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR032264" /db_xref="PDB:2X7J" /db_xref="SubtiList:BG10683" /db_xref="UniProtKB/Swiss-Prot:P23970" /translation="MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHP DISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVL TADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ KRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAE AEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLK DDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIH CNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQH LVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAP VTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGT PTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDM LNEAVREVKKQWEL*" /label="menD CDS" gene complement(2570590..2572332) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /label="menD gene" CDS complement(2572329..2573744) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /EC_number="5.4.4.2" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinone-specific isochorismate synthase" /protein_id="NP_390961.1" /db_xref="EnsemblGenomes-Gn:BSU30830" /db_xref="EnsemblGenomes-Tr:CAB15061" /db_xref="GOA:P23973" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR034681" /db_xref="SubtiList:BG10682" /db_xref="UniProtKB/Swiss-Prot:P23973" /translation="MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFF NYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFH IYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTV NRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQ IKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPER LIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSS CSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVD VIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPIS EYEETQIKLKPMISALGGERR*" /label="menF CDS" gene complement(2572329..2573744) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /label="menF gene" S_feature complement(2573745..2573857) /Source="Nicolas_S_feature" /locus_tag="new_3153718_3153830_c" /HighExp="dia5, LBGstat, Diami, LBGtran, dia15, H2O2, G180, G150, LPhT, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1176" promotor_-10 complement(2573837..2573856) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-10" upshifts complement(2573857) /Source="Nicolas_upshifts" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="upshifts" S_feature complement(2573859..2574009) /Source="Nicolas_S_feature" /locus_tag="new_3153832_3153982_c" /HighExp="S8, S7, S6, S5, BT, S4, Pyr, B36, G/S, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1177" promotor_-35 complement(2573872..2573875) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-35" promotor_-35 2573970..2573976 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2573990..2574009) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2573990..2574001 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2573998 /Source="Nicolas_upshifts" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2574009) /Source="Nicolas_upshifts" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2574023..2574032) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2574034..2574753 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative regulatory protein" /protein_id="NP_390962.2" /db_xref="EnsemblGenomes-Gn:BSU30840" /db_xref="EnsemblGenomes-Tr:CAB15062" /db_xref="GOA:P42408" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR014240" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG11200" /db_xref="UniProtKB/Swiss-Prot:P42408" /translation="MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGE LSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIP FERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDV EKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHE RYEEELDEEGIMTTFGDLHAD*" /label="yteA CDS" gene 2574034..2574753 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /label="yteA gene" S_feature complement(2574104..2574761) /Source="Nicolas_S_feature" /locus_tag="new_3154077_3154734_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, S3" /AntisenseName="yteA" /AntisenseCor="0.85796245341056299" /AntisenseRegPval="-78.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1178" downshifts 2574742 /Source="Nicolas_upshifts" /id="D1588" /incds=0 /nref=23 /ntot=40 /MaxReadThrough="0.72949" /MaxDrop="5.85132" /score="2.75726503" /energy="-10.1" /TU="NA" /idTUdmin="U2391" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2574762..2575580) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_390963.1" /db_xref="EnsemblGenomes-Gn:BSU30850" /db_xref="EnsemblGenomes-Tr:CAB15063" /db_xref="GOA:P42407" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11199" /db_xref="UniProtKB/Swiss-Prot:P42407" /translation="MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELK ESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPY AKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETK TEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEA DSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ*" /label="ytdA CDS" gene complement(2574762..2575580) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /label="ytdA gene" promotor_-10 complement(2575601..2575620) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2575615) /Source="Nicolas_upshifts" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2575635..2575643) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2575681..2575689 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2575702..2575721 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2575703 /Source="Nicolas_upshifts" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="upshifts" CDS 2575752..2577038 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /EC_number="1.1.1.22" /function="16.14: Store" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose dehydrogenase" /protein_id="NP_390964.1" /db_xref="EnsemblGenomes-Gn:BSU30860" /db_xref="EnsemblGenomes-Tr:CAB15064" /db_xref="GOA:O34862" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13828" /db_xref="UniProtKB/Swiss-Prot:O34862" /translation="MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVI PFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGD LSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFIN EMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNT ETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLM ERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWK KAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP*" /label="ytcA CDS" gene 2575752..2577038 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /label="ytcA gene" CDS 2577035..2577985 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose epimerase" /protein_id="NP_390965.1" /db_xref="EnsemblGenomes-Gn:BSU30870" /db_xref="EnsemblGenomes-Tr:CAB15065" /db_xref="GOA:O34886" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13829" /db_xref="UniProtKB/Swiss-Prot:O34886" /translation="MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKL KNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHN IQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLC HVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYI SDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEP SNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE*" /label="ytcB CDS" gene 2577035..2577985 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /label="ytcB gene" CDS 2577988..2579211 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /EC_number="2.4.1.-" /function="16.14: Store" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glucosyltransferase" /protein_id="NP_390966.1" /db_xref="EnsemblGenomes-Gn:BSU30880" /db_xref="EnsemblGenomes-Tr:CAB15066" /db_xref="GOA:O34413" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG13830" /db_xref="UniProtKB/Swiss-Prot:O34413" /translation="MKLAFICTEKLPAPAVRGGAIQMMIDGVTPYFSSRYDLTIFSIE DPSLPKRETKDGVHYIHLPKEHYREAVAEELRASSFDLIHVFNRPLNVSLYKKASPNS KIVLSLHNEMFSEKKMTFAQGKEVLDNVSMITTVSEFIKQTVIERFPEAEDITKVVYS GVDLNSYPPVWTMKGSAVRKTYRKKYGIEDKKVILFAGRLSPTKGPHLLIHSMRRILQ QHPDAVLVIAGGKWFSDDSENQYVTYLRTLALPYRDHIIFTKFIPADDIPNLFLMADV FVCSSQWNEPLARVNYEAMAAGTPLITTNRGGNGEVVKHEVTGLVIDSYNKPSSFAKA IDRAFTDQELMNKMTKNARKHVEALFTFTHAAKRLNTVYQSVLTPKNKQFPPPFLTQN FDLSSINQLFVKAKT*" /label="ytcC CDS" gene 2577988..2579211 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /label="ytcC gene" downshifts complement(2579135) /Source="Nicolas_upshifts" /id="D1589" /incds=1 /nref=1 /ntot=10 /MaxReadThrough="1.32025" /MaxDrop="3.47267" /score="-3.65321449" /energy="-3.1" /TU="NA" /idTUdmin="U2395" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2579212..2579779 /Source="Nicolas_S_feature" /locus_tag="new_3159185_3159752" /HighExp="S8, S7, BT, S6, C30, Pyr, S5, G/S, C90, Glucon" /AntisenseName="ytxO" /AntisenseCor="0.86121563743373297" /AntisenseRegPval="-79.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1179" CDS complement(2579285..2579716) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="outer spore coat protein" /protein_id="NP_390967.1" /db_xref="EnsemblGenomes-Gn:BSU30890" /db_xref="EnsemblGenomes-Tr:CAB15067" /db_xref="SubtiList:BG11382" /db_xref="UniProtKB/Swiss-Prot:P46916" /translation="MRSSRQKASISKLDLDQFVFTPPGPMGWQAHDSISAEKEEEEKH LDVGSIRELPHINAPKEYQKETKEKETDRKIVDDEEETKFETTLEPEEERDSKRSAPP YEEEDEDEEPDLAEEAKVEIIILPSESKPAPWFSQTVKRKA*" /label="cotOO CDS" gene complement(2579285..2579716) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /label="cotOO gene" downshifts complement(2579311) /Source="Nicolas_upshifts" /id="D1590" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="3.07378" /MaxDrop="4.8822" /score="9.30990044" /energy="-8.3" /TU="U2395" /idTUdmin="U2395" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(2579718..2580773) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7545510, 9603889, 10234840, 11737650, 14702409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7545510, 9603889, 10234840, 11737650, 14702409; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390968.1" /db_xref="EnsemblGenomes-Gn:BSU30900" /db_xref="EnsemblGenomes-Tr:CAB15068" /db_xref="GOA:P46914" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="SubtiList:BG11380" /db_xref="UniProtKB/Swiss-Prot:P46914" /translation="MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHG PKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVT GKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGN MQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFT LARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVY PLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFL DKLPELYKKIKAYREAN*" /label="cotS CDS" gene complement(2579718..2580773) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /label="cotS gene" CDS complement(2580788..2581921) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9603889, 10234840, 11737650" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9603889, 10234840, 11737650; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390969.1" /db_xref="EnsemblGenomes-Gn:BSU30910" /db_xref="EnsemblGenomes-Tr:CAB15069" /db_xref="GOA:P46915" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11381" /db_xref="UniProtKB/Swiss-Prot:P46915" /translation="MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIK DPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDA VFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYS GVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIE EHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDV FVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAER INDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR*" /label="cotSA CDS" gene complement(2580788..2581921) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /label="cotSA gene" promotor_-10 complement(2581954..2581973) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2581973) /Source="Nicolas_upshifts" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2581986..2581995) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2582059..2582068 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2582082..2582101 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2582084 /Source="Nicolas_upshifts" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="upshifts" CDS 2582111..2583184 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816, 20077512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 20077512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat kinase" /protein_id="NP_390970.1" /db_xref="EnsemblGenomes-Gn:BSU30920" /db_xref="EnsemblGenomes-Tr:CAB15070" /db_xref="GOA:O34656" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="PDB:2Q83" /db_xref="SubtiList:BG13821" /db_xref="UniProtKB/Swiss-Prot:O34656" /translation="MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQ AEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGIL PNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGV PIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLL QSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSAL PKEELESAFEYERIKANALRQLI*" /label="cotI CDS" gene 2582111..2583184 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /label="cotI gene" promotor_-35 2582408..2582414 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2582425 /Source="Nicolas_upshifts" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2582428..2582439 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2583173 /Source="Nicolas_upshifts" /id="D1591" /incds=0 /nref=16 /ntot=35 /MaxReadThrough="3.14769" /MaxDrop="5.1897" /score="-2.47616606" /energy="-10.3" /TU="U2396,U2397" /idTUdmin="U2396" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2583211..2583217 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2583232 /Source="Nicolas_upshifts" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2583233..2583251 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2583264..2583731 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717291, 15849754, 16850406; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative receptor" /protein_id="NP_390971.1" /db_xref="EnsemblGenomes-Gn:BSU30930" /db_xref="EnsemblGenomes-Tr:CAB15071" /db_xref="GOA:O34694" /db_xref="InterPro:IPR004307" /db_xref="SubtiList:BG13822" /db_xref="UniProtKB/Swiss-Prot:O34694" /translation="MKKIVGALAVFVITYALFSAAGYLFPVDQEWYNSLKKPDWTPSG TAIGIIWAILFALISLSAAIVYAAFSFKGAKSFWFTLLINYVLNQAFSYFQFTQKNLL AASLDCLLVAITAIVLLIIAKKYSRAASYLLLPYFLWSAFATFLSFTINSMNL*" /label="ytaB CDS" gene 2583264..2583731 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /label="ytaB gene" downshifts 2583703 /Source="Nicolas_upshifts" /id="D1592" /incds=0 /nref=43 /ntot=123 /MaxReadThrough="2.47485" /MaxDrop="5.7907" /score="9.10214462" /energy="-10.1" /TU="NA" /idTUdmin="U2396" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2583762..2586158) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /EC_number="2.4.1.1" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8145641, 9244254, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen phosphorylase" /protein_id="NP_390972.1" /db_xref="EnsemblGenomes-Gn:BSU30940" /db_xref="EnsemblGenomes-Tr:CAB15072" /db_xref="GOA:P39123" /db_xref="InterPro:IPR000811" /db_xref="InterPro:IPR011833" /db_xref="InterPro:IPR035090" /db_xref="SubtiList:BG10911" /db_xref="UniProtKB/Swiss-Prot:P39123" /translation="MFSSKERFADLFLKRLEMTCGKSFKDSAKLDQYKTLGNMVREYI SADWIETNEKSRSNSGKQTYYLSIEFLLGQLLEQNLMNLGVRDVVEAGLKEIGINLEE ILQIENDAGLGNGGLGRLAACFLDSLASLNLPGHGMGIRYKHGLFEQKIVDGHQVELP EQWLKNGNVWEVRNADQAVDVPFWGEVHMTEKSGRLHFRHEQATIVTAVPYDIPIIGY ETGTVNTLRLWNAEPYAHYHGGNILSYKRETEAVSEFLYPDDTHDEGKILRLKQQYFL VCASLKSIVNNYRKTHKSLSGLHKKVSIHINDTHPALAVPELMRILLDEENMSWEEAW HITVHTISYTNHTTLSEALEKWPIHLFKPLLPRMYMIIEEINERFCRAVWEKYPGDWK RIENMAITAHGVVKMAHLAIVGSYSVNGVAKIHSDILKEREMRDFHLLFPNRFNNKTN GIAHRRWLLKANPGLSAIITEAIGDEWVKQPESLIRLEPYATDPAFIEQFQNNKSKKK QELADLIFCTAGVVVNPESIFDVQVKRLHAYKRQLLNVLHIMYLYNRLKEDSGFSIYP QTFIFGAKASPSYYYAKKIIKLIHSVAEKVNYDPAVKQLIKVVFLENYRVSMAERIFP ASDVSEQISTASKEASGTGNMKFMMNGALTIGTHDGANIEILERVGPDCIYTFGLKAD EVLSYQENGGYRSREYYQHDRRIRQVADQLINGFFEGEADEFESIFDSLLPHNDEYFV LKDFSSYADAQERIQADYRERRKWSEHSIVNIAHSGYFSSDRTIREYAKDIWGIKPMM *" /label="glgP CDS" gene complement(2583762..2586158) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /label="glgP gene" downshifts complement(2583777) /Source="Nicolas_upshifts" /id="D1593" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="2.31076" /MaxDrop="4.39135" /score="34.694666" /energy="-10.1" /TU="NA" /idTUdmin="U2399" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2586145..2587599) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /EC_number="2.4.1.21" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:8145641, 15272305" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8145641, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen (starch) synthase" /protein_id="NP_390973.1" /db_xref="EnsemblGenomes-Gn:BSU30950" /db_xref="EnsemblGenomes-Tr:CAB15073" /db_xref="GOA:P39125" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /db_xref="SubtiList:BG10910" /db_xref="UniProtKB/Swiss-Prot:P39125" /translation="MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKY SQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHY DDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVL TIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTY RNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLE NKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGER EFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYG AIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSI VKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE*" /label="glgA CDS" gene complement(2586145..2587599) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /label="glgA gene" CDS complement(2587596..2588627) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) beta subunit" /protein_id="NP_390974.1" /db_xref="EnsemblGenomes-Gn:BSU30960" /db_xref="EnsemblGenomes-Tr:CAB15074" /db_xref="GOA:P39124" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011832" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10909" /db_xref="UniProtKB/Swiss-Prot:P39124" /translation="MFNNQMLGVIDETTYKHSLQDLTAQRSLGAIPFAGRYRLIDFML SNMVNADIRSVAIFPKYRYRSLMDHLGAGKEWDLHRKKDGLFFFPSPHLHHEYDEFGS FRQFSDHLDYFHRSTQQYAVISNSHTVCNIQFQYVLKRHQEVGCDVTEVFQDGQSLQI YIMSTTLLKDLIYGHSEKGYKTIQEAVEKESSALTICPYEYSGYAAVIDSVEKYYTHS MELIQPRFWQQVFLPQQPIYTKVKDEPPTKYGKHSTVKNSLVANGCVLEGEVENCILF RAVHVGKGTKLKNCIIMQKTQIGEDCLLEQVISDKDVKIGKATEAAGTAEQPLVLRKG LVQGELMNS*" /label="glgD CDS" gene complement(2587596..2588627) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /label="glgD gene" CDS complement(2588651..2589793) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha" /protein_id="NP_390975.1" /db_xref="EnsemblGenomes-Gn:BSU30970" /db_xref="EnsemblGenomes-Tr:CAB15075" /db_xref="GOA:P39122" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10908" /db_xref="UniProtKB/Swiss-Prot:P39122" /translation="MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLS NCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGT ASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEA SRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDF GKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYS VNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVT IGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI*" /label="glgC CDS" gene complement(2588651..2589793) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /label="glgC gene" CDS complement(2589790..2591673) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /EC_number="2.4.1.18" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1296817, 15272305, 8145641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-alpha-glucan branching enzyme" /protein_id="NP_390976.1" /db_xref="EnsemblGenomes-Gn:BSU30980" /db_xref="EnsemblGenomes-Tr:CAB15076" /db_xref="GOA:P39118" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR006048" /db_xref="InterPro:IPR006407" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG10907" /db_xref="UniProtKB/Swiss-Prot:P39118" /translation="MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVW APHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRL KADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKK HSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGP PHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGT ANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLK KLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPE ERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGY MTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKIL YEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFT QYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGE IKR*" /label="glgB CDS" gene complement(2589790..2591673) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /label="glgB gene" S_feature 2590499..2591918 /Source="Nicolas_S_feature" /locus_tag="new_3170472_3171891" /HighExp="S8, S7, S6, C30, BT, Pyr, G/S, S2, C90, BC" /AntisenseName="glgB" /AntisenseCor="0.59299722159013002" /AntisenseRegPval="-26.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1180" promotor_-10 complement(2591705..2591720) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2591718) /Source="Nicolas_upshifts" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2591735..2591740) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2591785) /Source="Nicolas_upshifts" /id="D1594" /incds=0 /nref=2 /ntot=46 /MaxReadThrough="1.66182" /MaxDrop="3.12741" /score="36.0363304" /energy="-9.2" /TU="NA" /idTUdmin="U2401" /TUdmin=198 /isTUend="FALSE" /label="downshifts" tRNA complement(2591906..2591977) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Glu tRNA" gene complement(2591906..2591977) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /label="trnB-Glu gene" tRNA complement(2592003..2592093) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser2 tRNA" gene complement(2592003..2592093) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /label="trnB-Ser2 gene" tRNA complement(2592097..2592171) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asn tRNA" gene complement(2592097..2592171) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /label="trnB-Asn gene" tRNA complement(2592182..2592258) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ile2 tRNA" gene complement(2592182..2592258) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /label="trnB-Ile2 gene" tRNA complement(2592274..2592347) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly2 tRNA" gene complement(2592274..2592347) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /label="trnB-Gly2 gene" tRNA complement(2592358..2592433) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-His tRNA" gene complement(2592358..2592433) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /label="trnB-His gene" tRNA complement(2592451..2592526) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Phe tRNA" gene complement(2592451..2592526) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /label="trnB-Phe gene" tRNA complement(2592539..2592615) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asp tRNA" gene complement(2592539..2592615) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /label="trnB-Asp gene" tRNA complement(2592627..2592703) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met2 tRNA" gene complement(2592627..2592703) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /label="trnB-Met2 gene" tRNA complement(2592721..2592813) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser1 tRNA" gene complement(2592721..2592813) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /label="trnB-Ser1 gene" tRNA complement(2592820..2592896) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met3 tRNA" gene complement(2592820..2592896) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /label="trnB-Met3 gene" tRNA complement(2592899..2592975) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met1 tRNA" gene complement(2592899..2592975) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /label="trnB-Met1 gene" tRNA complement(2592995..2593067) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ala tRNA" gene complement(2592995..2593067) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /label="trnB-Ala gene" tRNA complement(2593073..2593149) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Pro tRNA" gene complement(2593073..2593149) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /label="trnB-Pro gene" tRNA complement(2593165..2593241) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Arg tRNA" gene complement(2593165..2593241) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /label="trnB-Arg gene" tRNA complement(2593251..2593336) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu2 tRNA" gene complement(2593251..2593336) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /label="trnB-Leu2 gene" tRNA complement(2593351..2593425) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly1 tRNA" gene complement(2593351..2593425) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /label="trnB-Gly1 gene" tRNA complement(2593431..2593517) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu1 tRNA" gene complement(2593431..2593517) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /label="trnB-Leu1 gene" tRNA complement(2593528..2593603) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Lys tRNA" gene complement(2593528..2593603) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /label="trnB-Lys gene" tRNA complement(2593641..2593716) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Thr tRNA" gene complement(2593641..2593716) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /label="trnB-Thr gene" tRNA complement(2593749..2593824) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Val tRNA" gene complement(2593749..2593824) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /label="trnB-Val gene" rRNA complement(2593845..2593962) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-5S rRNA" gene complement(2593845..2593962) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /label="rrnB-5S gene" rRNA complement(2594018..2596945) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-23S rRNA" gene complement(2594018..2596945) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /label="rrnB-23S gene" rRNA complement(2597113..2598667) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-16S rRNA" gene complement(2597113..2598667) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /label="rrnB-16S gene" Polymorphism join(2598469,2598471) /Source="geneious" /ID="SNP_BsDelta6_3178443_3178443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="T -> C" /Codon_Change /Coverage=95 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="3.5e-102" /Variant_Raw_Frequency=94 /comment="rrnB-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" S_feature complement(2598668..2598959) /Source="Nicolas_S_feature" /locus_tag="new_3178641_3178932_c" /HighExp="Diami, LPhT, C30, LBGstat, HPh, GM 120, Oxctl, Paraq, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40784100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1181" misc_feature 2598795..2598803 /Source="Nicolas_upshift_promotors" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2598801 /Source="Nicolas_upshifts" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2598911 /Source="Nicolas_upshifts" /id="D1595" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="2.91899" /MaxDrop="4.63941" /score="-0.368124787" /energy="-10.2" /TU="U2400" /idTUdmin="U2400" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2598932..2598951) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2598959) /Source="Nicolas_upshifts" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2598961..2599927) /Source="Nicolas_S_feature" /locus_tag="new_3178934_3179900_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T0.0H, T3.0H, T-0.40H, S8, T3.30H" /AntisenseName="thiT" /AntisenseCor="-0.219467435413819" /AntisenseRegPval="-3.5" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1182" promotor_-35 complement(2598965..2598972) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2599084..2599087 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2599099 /Source="Nicolas_upshifts" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2599102..2599121 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2599132..2599233 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswC RNA" gene 2599132..2599233 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /label="tswC gene" downshifts 2599232 /Source="Nicolas_upshifts" /id="D1596" /incds=0 /nref=47 /ntot=135 /MaxReadThrough="5.85975" /MaxDrop="7.03111" /score="-0.368124787" /energy="-10.2" /TU="U2402" /idTUdmin="U2400" /TUdmin=299 /isTUend="FALSE" /label="downshifts" CDS 2599333..2599911 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 19181806" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 19181806; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamin permease" /protein_id="NP_390977.1" /db_xref="EnsemblGenomes-Gn:BSU30990" /db_xref="EnsemblGenomes-Tr:CAB15077" /db_xref="GOA:O32074" /db_xref="InterPro:IPR012651" /db_xref="SubtiList:BG13949" /db_xref="UniProtKB/Swiss-Prot:O32074" /translation="MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMI PIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFAS SVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTY NATYMVPSFIICAIVLCLLFMTAPRLLKSDKA*" /label="thiT CDS" gene 2599333..2599911 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /label="thiT gene" downshifts 2599901 /Source="Nicolas_upshifts" /id="D1597" /incds=0 /nref=129 /ntot=206 /MaxReadThrough="1.91553" /MaxDrop="5.49387" /score="35.5376279" /energy="-19.5" /TU="NA" /idTUdmin="U2402" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2599953..2600474) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390978.1" /db_xref="EnsemblGenomes-Gn:BSU31000" /db_xref="EnsemblGenomes-Tr:CAB15078" /db_xref="GOA:O32075" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13948" /db_xref="UniProtKB/Swiss-Prot:O32075" /translation="MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEF EDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGR ALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLG WPDLSALKTLLNR*" /label="yuaI CDS" gene complement(2599953..2600474) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /label="yuaI gene" downshifts complement(2599971) /Source="Nicolas_upshifts" /id="D1598" /incds=0 /nref=8 /ntot=143 /MaxReadThrough="6.18352" /MaxDrop="5.43101" /score="13.1646679" /energy="-19.6" /TU="U2403" /idTUdmin="U2405" /TUdmin=6 /isTUend="TRUE" /label="downshifts" downshifts complement(2600043) /Source="Nicolas_upshifts" /id="D1599" /incds=1 /nref=8 /ntot=208 /MaxReadThrough="8.2849" /MaxDrop="3.3545" /score="13.1646679" /energy="-19.6" /TU="U2403,U2405" /idTUdmin="U2405" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2600492..2602021) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /experiment="publication(s) with functional evidences, PMID:9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845; Product type s: structure" /codon_start=1 /transl_table=11 /product="flotillin lipid rafts scaffold protein" /protein_id="NP_390979.1" /db_xref="EnsemblGenomes-Gn:BSU31010" /db_xref="EnsemblGenomes-Tr:CAB15079" /db_xref="GOA:O32076" /db_xref="InterPro:IPR001107" /db_xref="InterPro:IPR027705" /db_xref="InterPro:IPR031905" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG13947" /db_xref="UniProtKB/Swiss-Prot:O32076" /translation="MTMPIIMIIGVVFFLLIALIAVFITKYRTAGPDEALIVTGSYLG NKNVHVDEGGNRIKIVRGGGTFVLPVFQQAEPLSLLSSKLDVSTPEVYTEQGVPVMAD GTAIIKIGGSIGEIATAAEQFLGKSKDDREQEAREVLEGHLRSILGSMTVEEIYKNRE KFSQEVQRVASQDLAKMGLVIVSFTIKDVRDKNGYLESLGKPRIAQVKRDADIATAEA DKETRIKRAEADKDAKKSELERATEIAEAEKINQLKMAEFRREQDTAKANADQAYDLE TARARQQVTEQEMQVKIIERQKQIELEEKEILRRERQYDSEVKKKADADRYSVEQSAA AEKAKQLAEADAKKYSIEAMAKAEAEKVRIDGLAKAEAEKAKGETEAEVIRLKGLAEA EAKEKIAAAFEQYGQAAIFDMIVKMLPEYAKQAAAPLSNIDKITVVDTGGSGESSGAN KVTSYATNLMSSLQESLKASSGIDVKEMLENFSGKGNVKQSINELTNEIKEAKTIQKS E*" /label="floT CDS" gene complement(2600492..2602021) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /label="floT gene" CDS complement(2602042..2602566) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12533473, 15849754, 16850406, 18696230, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane integrity integral membrane protein" /protein_id="NP_390980.1" /db_xref="EnsemblGenomes-Gn:BSU31020" /db_xref="EnsemblGenomes-Tr:CAB15080" /db_xref="GOA:O32077" /db_xref="PDB:2K14" /db_xref="SubtiList:BG13946" /db_xref="UniProtKB/Swiss-Prot:O32077" /translation="MELFGVPIQTMYLYTLIIAGSLTLLFLFFGDVFSGLSEGIPFLN PTLVLSFFTCFSAGGYIGELVLPLSSLLIALLSCILSIMLVVLLHIFVLVPLSSAEES LAYREDDLRGRLGKVITAVPVDGFGEVVIEGIGGTISKSAVSFDNQQISYGTTVLVVD INNGVLSVTPHEPI*" /label="nfeDB CDS" gene complement(2602042..2602566) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /label="nfeDB gene" promotor_-10 complement(2602610..2602625) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-10" upshifts complement(2602616) /Source="Nicolas_upshifts" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="upshifts" S_feature complement(2602618..2602705) /Source="Nicolas_S_feature" /locus_tag="new_3182591_3182678_c" /HighExp="S4, S8, S6, S7, S5, S3, B36, LoTm, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S1183" promotor_-35 complement(2602637..2602646) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-35" promotor_-10 complement(2602690..2602708) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2602700 /Source="Nicolas_upshifts" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2602704..2602723 /Source="Nicolas_upshift_promotors" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2602705) /Source="Nicolas_upshifts" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2602723..2602728) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2602734..2603222 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390981.1" /db_xref="EnsemblGenomes-Gn:BSU31030" /db_xref="EnsemblGenomes-Tr:CAB15081" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG13945" /db_xref="UniProtKB/Swiss-Prot:O32078" /translation="MSIFNEARLETWNELKGLSDEKLNQKPSAEEWSIREVLDHLKKI DMTAQKMLKERVKDAPIKEIEEKPLEVAQDRNNKRKAPSHLEPAHDFISGSQMKRELD VVREQLTAAIASLKEEDFERVLPHPVFQELTVRQWIDFIGHHEKRHLSQMKEIKEKIE RA*" /label="yuaE CDS" gene 2602734..2603222 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /label="yuaE gene" downshifts 2603199 /Source="Nicolas_upshifts" /id="D1600" /incds=0 /nref=205 /ntot=267 /MaxReadThrough="4.05856" /MaxDrop="6.05192" /score="-4.20632485" /energy="-15" /TU="U2404" /idTUdmin="U2404" /TUdmin="-354" /isTUend="FALSE" /label="downshifts" CDS complement(2603228..2603806) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11886751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390982.1" /db_xref="EnsemblGenomes-Gn:BSU31040" /db_xref="EnsemblGenomes-Tr:CAB15082" /db_xref="GOA:O32079" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="PDB:1ORU" /db_xref="SubtiList:BG13944" /db_xref="UniProtKB/Swiss-Prot:O32079" /translation="MWKRMTAKAEGLYIADTKSFVTKQMDKLDFDYGGIPGDLHFGLT KKAGAREPMFSRGTEIFNRRQISIVSIEECNEIALKMGVPRILPEWLGANVAVSGMPD LTSLKEGSRIIFPSGAALLCEGENDPCIQPGEVIQSYYPDQPKLASAFVRHALGIRGI VCIVERPGAVYTGDEIEVHSYQRKVKRKAERV*" /label="yuaD CDS" gene complement(2603228..2603806) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /label="yuaD gene" S_feature 2603244..2603635 /Source="Nicolas_S_feature" /locus_tag="new_3183217_3183608" /HighExp="Etha, S8, LPhT, S6, Salt, LoTm, S5, H2O2, S7, dia5" /AntisenseName="yuaD" /AntisenseCor="-0.48344313728748101" /AntisenseRegPval="-16.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S1184" downshifts complement(2603255) /Source="Nicolas_upshifts" /id="D1601" /incds=0 /nref=87 /ntot=222 /MaxReadThrough="0.58189" /MaxDrop="3.9885" /score="0.718873117" /energy="-11.5" /TU="NA" /idTUdmin="U2406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2603840..2603859) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2603849) /Source="Nicolas_upshifts" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2603873..2603880) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2603894..2605102) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /EC_number="1.1.99.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="choline dehydrogenase" /protein_id="NP_390983.2" /db_xref="EnsemblGenomes-Gn:BSU31050" /db_xref="EnsemblGenomes-Tr:CAB15083" /db_xref="GOA:P71017" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG11941" /db_xref="UniProtKB/Swiss-Prot:P71017" /translation="MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKA LLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGL VAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVT QWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTM KFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAH AMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAK ASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYK RCFNLTPKTV*" /label="gbsB CDS" gene complement(2603894..2605102) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /label="gbsB gene" downshifts complement(2603915) /Source="Nicolas_upshifts" /id="D1602" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="2.9443" /MaxDrop="3.26923" /score="18.315772" /energy="-13.6" /TU="NA" /idTUdmin="U2406" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2604871..2604890) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2604883) /Source="Nicolas_upshifts" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2604905..2604912) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2605119..2606591) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /EC_number="1.2.1.8" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 9297465, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 9297465, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine betaine aldehyde dehydrogenase, NAD+-dependent" /protein_id="NP_390984.1" /db_xref="EnsemblGenomes-Gn:BSU31060" /db_xref="EnsemblGenomes-Tr:CAB15084" /db_xref="GOA:P71016" /db_xref="InterPro:IPR011264" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11940" /db_xref="UniProtKB/Swiss-Prot:P71016" /translation="MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIK AIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKAD MDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWK IAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNK DVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVF FHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKV EKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTV ETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPW GGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS*" /label="gbsA CDS" gene complement(2605119..2606591) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /label="gbsA gene" promotor_-10 complement(2606642..2606661) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2606643) /Source="Nicolas_upshifts" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2606676..2606683) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2606703..2606709 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2606723..2606742 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2606738 /Source="Nicolas_upshifts" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2606790..2607332 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor for gbsAB" /protein_id="NP_390985.1" /db_xref="EnsemblGenomes-Gn:BSU31070" /db_xref="EnsemblGenomes-Tr:CAB15085" /db_xref="GOA:P71015" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12342" /db_xref="UniProtKB/Swiss-Prot:P71015" /translation="MDENPEFAAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMR DEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRKHTFVAEKDFFKFFTNF FPPKWEREVQVNVTAIEEAQADLQKVLCKEDLDEDIKNEALQLYDQLESSKAYYDWLK RLAESVQTGEIFKFIPVETK*" /label="gbsR CDS" gene 2606790..2607332 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /label="gbsR gene" downshifts 2607315 /Source="Nicolas_upshifts" /id="D1603" /incds=0 /nref=74 /ntot=220 /MaxReadThrough="1.70461" /MaxDrop="3.5918" /score="26.1509691" /energy="-9.9" /TU="NA" /idTUdmin="U2409" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2607409..2607416 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2607429..2607529 /Source="Nicolas_S_feature" /locus_tag="new_3187402_3187502" /HighExp="BT, S0, BI, T-1.10H, T-1.40H, T1.0H, T-0.40H, T0.0H, S2, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1185" upshifts 2607429 /Source="Nicolas_upshifts" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2607431..2607450 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2607530..2608075 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /function="15.3: Cell adhesion" /experiment="publication(s) with functional evidences, PMID:21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732; Product type s: structure" /codon_start=1 /transl_table=11 /product="biofilm hydrophobic layer component" /protein_id="NP_390986.1" /db_xref="EnsemblGenomes-Gn:BSU31080" /db_xref="EnsemblGenomes-Tr:CAB15086" /db_xref="GOA:P71014" /db_xref="InterPro:IPR034650" /db_xref="PDB:4BHU" /db_xref="SubtiList:BG12341" /db_xref="UniProtKB/Swiss-Prot:P71014" /translation="MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRT QSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNA LRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFY AEASIDVAKRSTPPTQPCGCN*" /label="bslA CDS" gene 2607530..2608075 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /label="bslA gene" downshifts 2608062 /Source="Nicolas_upshifts" /id="D1604" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="0.85027" /MaxDrop="6.00835" /score="20.8976757" /energy="-10.2" /TU="NA" /idTUdmin="U2410" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2608167..2608174 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2608188..2608207 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2608195 /Source="Nicolas_upshifts" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2608200..2608368 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /product="cyclic-di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751; Product type n: RNA" /label="swdA RNA" gene 2608200..2608368 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /label="swdA gene" downshifts 2608349 /Source="Nicolas_upshifts" /id="D1605" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="6.04086" /MaxDrop="4.75274" /score="3.29445061" /energy="-6.1" /TU="U2411" /idTUdmin="U2410" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 2608441..2609109 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 23598340, 23671116, 25957408, 26771197" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 23598340, 23671116, 25957408, 26771197; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_390987.1" /db_xref="EnsemblGenomes-Gn:BSU31090" /db_xref="EnsemblGenomes-Tr:CAB15087" /db_xref="GOA:O32080" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="PDB:1LSU" /db_xref="PDB:2HMS" /db_xref="PDB:2HMT" /db_xref="PDB:2HMU" /db_xref="PDB:2HMV" /db_xref="PDB:2HMW" /db_xref="PDB:4J7C" /db_xref="PDB:4J90" /db_xref="PDB:4J91" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13943" /db_xref="UniProtKB/Swiss-Prot:O32080" /translation="MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNA YASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWV KAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATR KLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFE NEGM*" /label="ktrA CDS" gene 2608441..2609109 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /label="ktrA gene" CDS 2609116..2610453 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium transporter ATPase" /protein_id="NP_390988.1" /db_xref="EnsemblGenomes-Gn:BSU31100" /db_xref="EnsemblGenomes-Tr:CAB15088" /db_xref="GOA:O32081" /db_xref="InterPro:IPR003445" /db_xref="InterPro:IPR004772" /db_xref="PDB:4J7C" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13956" /db_xref="UniProtKB/Swiss-Prot:O32081" /translation="MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKP LSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMIL GKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSS GLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKN RRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTP RTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKK ETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVG LTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG*" /label="ktrB CDS" gene 2609116..2610453 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /label="ktrB gene" downshifts 2610439 /Source="Nicolas_upshifts" /id="D1606" /incds=0 /nref=9 /ntot=98 /MaxReadThrough="0.86883" /MaxDrop="3.37604" /score="25.8974852" /energy="-11.9" /TU="NA" /idTUdmin="U2411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2610489..2610752) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390989.1" /db_xref="EnsemblGenomes-Gn:BSU31110" /db_xref="EnsemblGenomes-Tr:CAB15089" /db_xref="GOA:O32082" /db_xref="InterPro:IPR008024" /db_xref="SubtiList:BG13955" /db_xref="UniProtKB/Swiss-Prot:O32082" /translation="MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGY YIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES*" /label="yubF CDS" gene complement(2610489..2610752) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /label="yubF gene" downshifts complement(2610507) /Source="Nicolas_upshifts" /id="D1607" /incds=0 /nref=237 /ntot=309 /MaxReadThrough="2.4577" /MaxDrop="7.13564" /score="30.2020977" /energy="-11.9" /TU="NA" /idTUdmin="U2412" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2610792..2610811) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2610794) /Source="Nicolas_upshifts" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2610824..2610831) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2610861..2611709) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /EC_number="3.2.1.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12525152, 16855244, 28448118, 28811162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12525152, 16855244, 28448118, 28811162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exoglucosaminidase" /protein_id="NP_390990.1" /db_xref="EnsemblGenomes-Gn:BSU31120" /db_xref="EnsemblGenomes-Tr:CAB15090" /db_xref="GOA:O32083" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR025987" /db_xref="SubtiList:BG13954" /db_xref="UniProtKB/Swiss-Prot:O32083" /translation="MARKKLKKRKLLISLFFLVSIPLALFVLATTLSKPIEISKETEE IDEQQVFIDSLSGHAQILYEKYHVLPSITIAQAILESDWGNSELAAKANNLFGVKGNY KGHHVTMETDEVEKGKRKTIRAKFRKYSTFFESMDDHAQLFVRGTSWNKKKYKPVLEA GNYKEAATALQTSGYATDPDYADKISAIVEKYDLDEYDEVNPSLKSVDLNASIKDSAV QDVWSKPSTDDRSIRLTSAQSYVGKDIKVVSKKQKGQSVWYQFQINDKLIGWIDDSAV EIKEAT*" /label="lytG CDS" gene complement(2610861..2611709) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /label="lytG gene" promotor_-10 complement(2611754..2611773) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2611764) /Source="Nicolas_upshifts" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2611788..2611795) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2611870..2613405) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28248504; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390991.1" /db_xref="EnsemblGenomes-Gn:BSU31130" /db_xref="EnsemblGenomes-Tr:CAB15091" /db_xref="GOA:O32084" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13953" /db_xref="UniProtKB/Swiss-Prot:O32084" /translation="MKTKHYWVISLLAVLAVGPGLMSNTALSSVQGLVQKTVGTSVFT SVNPILIGNMAFALLVPAGPLLRKKFGARPVYLASLPVFILGSLLIACSGDIALMAAG RFLQGAATGVMLMIMIPMLVLSFPIERRNYALLVLIGGFYGSVIIGTILGTIATSCGH WRWLFFIFGTLSLIGVAVSYFFLHDEHHGAADQEQPLDRAGILLSVFLAAASAVSFIF LQKWGLSSGYVWIGFGVTLCLLIGLLIVEYKVKNPFISIKLMLLPKPVLGLLIIAAGT ITVAVSLSAFQGLLRQMYDISQEHLILLSLTLLIGVAIAAILSALLYDKVGPGMLGII GGLILVFVNFQWLHIQDRSSLYMFAALFIMLAAGTGLTVAAGLMGAAMGGPLPDLVKR MTAVQFLRLFVYMGVPILIGFFTKKDAARQSGSVQDSMMTAYHDLFFISFILSVLLVC LSFCMNATGMGHKLAHKPHDKAKTAPEKPAVSAQGLSKATVKSYKVINDTEYRNALRN LQK*" /label="yubD CDS" gene complement(2611870..2613405) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /label="yubD gene" downshifts complement(2611879) /Source="Nicolas_upshifts" /id="D1608" /incds=0 /nref=45 /ntot=159 /MaxReadThrough="1.39941" /MaxDrop="4.26166" /score="-3.3162201" /energy="-5.7" /TU="NA" /idTUdmin="U2415" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 2613063..2613163 /Source="Nicolas_upshift_promotors" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2613123 /Source="Nicolas_upshifts" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2613189 /Source="Nicolas_upshifts" /id="D1609" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="0.0870599999999992" /MaxDrop="3.19459" /score="-1.6836786" /energy="-10.4" /TU="NA" /idTUdmin="U2416" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature complement(2613406..2613573) /Source="Nicolas_S_feature" /locus_tag="new_3193379_3193546_c" /HighExp="Cold, S8, G180, UNK1, C30, G135, S7, Lbexp, MG 25, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34877900000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1186" promotor_-10 complement(2613562..2613581) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2613573) /Source="Nicolas_upshifts" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2613575..2614452) /Source="Nicolas_S_feature" /locus_tag="new_3193548_3194425_c" /HighExp="G180, Cold, C30, G135, Paraq, Oxctl, S8, G150, H2O2, Heat" /AntisenseName="cdoA" /AntisenseCor="-2.3104546834536201E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1187" promotor_-35 complement(2613596..2613603) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2613815..2613824 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2613838..2613857 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2613838 /Source="Nicolas_upshifts" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="upshifts" CDS 2613890..2614375 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /EC_number="1.13.11.20" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10939241, 15699190, 16855246, 25307852, 26590284" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15699190, 16855246, 25307852, 26590284; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine dioxygenase" /protein_id="NP_390992.1" /db_xref="EnsemblGenomes-Gn:BSU31140" /db_xref="EnsemblGenomes-Tr:CAB15092" /db_xref="GOA:O32085" /db_xref="InterPro:IPR010300" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:3EQE" /db_xref="PDB:4QM8" /db_xref="PDB:4QM9" /db_xref="SubtiList:BG13952" /db_xref="UniProtKB/Swiss-Prot:O32085" /translation="MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPD QYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEH AELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLEN S*" /label="cdoA CDS" gene 2613890..2614375 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /label="cdoA gene" S_feature 2614376..2614662 /Source="Nicolas_S_feature" /locus_tag="new_3194349_3194635" /HighExp="S6, S8, S7, BT, S5, G/S, C30, Pyr, C90, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.53171800000000002" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1188" tRNA complement(2614482..2614554) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala (GGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Ala1 tRNA" gene complement(2614482..2614554) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /label="trnSL-Ala1 gene" downshifts complement(2614497) /Source="Nicolas_upshifts" /id="D1610" /incds=0 /nref=37 /ntot=180 /MaxReadThrough="3.88031" /MaxDrop="4.38957" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2614541) /Source="Nicolas_upshifts" /id="D1611" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.34085" /MaxDrop="4.19639" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2614565..2614584) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2614585) /Source="Nicolas_upshifts" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2614599..2614602) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2614619 /Source="Nicolas_upshifts" /id="D1612" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.04964" /MaxDrop="3.22361" /score="-1.6836786" /energy="-10.4" /TU="U2416" /idTUdmin="U2416" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2614662..2615492) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /EC_number="3.6.1.27" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15138271, 15849754, 16850406, 27528508, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15138271, 15849754, 16850406, 27528508, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl-pyrophosphate phosphatase" /protein_id="NP_390993.1" /db_xref="EnsemblGenomes-Gn:BSU31150" /db_xref="EnsemblGenomes-Tr:CAB15093" /db_xref="GOA:P94507" /db_xref="InterPro:IPR003824" /db_xref="SubtiList:BG13951" /db_xref="UniProtKB/Swiss-Prot:P94507" /translation="MTLWELFVAAILGIVEGLTEYAPVSSTGHMIIVDDIWLKSSNLM SEEAANSFKVVIQLGSILAVAIVFKDRILNLLGLKKNITSDQEQGHKLSIAQIAVGLV PAAVLGFLFEDYIDEYLFSVKTVAIGLIAGAILMLFADWVNKRKTATDTLDRISYKQA IAVGLFQCLSLWPGFSRSGSTISGGVILGLNHRAAADFTFIMAMPIMMGASFLSLVKH WDSLSSDLMPFFIVGFICAFVVALFVVRFFLRLINKIKLVPFAIYRIILGVILLLIMM *" /label="uppP CDS" gene complement(2614662..2615492) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /label="uppP gene" downshifts complement(2614673) /Source="Nicolas_upshifts" /id="D1613" /incds=0 /nref=60 /ntot=208 /MaxReadThrough="3.0552" /MaxDrop="5.61932" /score="-4.25033697" /energy="-6.7" /TU="U2419" /idTUdmin="U2419" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2615493..2615584) /Source="Nicolas_S_feature" /locus_tag="new_3195466_3195557_c" /HighExp="dia15, H2O2, Salt, Etha, dia5, LBGtran, M0t90, Lbstat, Mt0, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1189" CDS complement(2615585..2616751) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16385049, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390994.1" /db_xref="EnsemblGenomes-Gn:BSU31160" /db_xref="EnsemblGenomes-Tr:CAB15094" /db_xref="GOA:O32086" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13950" /db_xref="UniProtKB/Swiss-Prot:O32086" /translation="METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIF TPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIV SIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQ AATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQ TYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYL GPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFL LLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV*" /label="yubA CDS" gene complement(2615585..2616751) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /label="yubA gene" promotor_-35 2616747..2616751 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2616759..2616773 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2616775..2616794) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2616775 /Source="Nicolas_upshifts" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2616794) /Source="Nicolas_upshifts" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2616808..2616815) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2616873..2616880 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2616886 /Source="Nicolas_upshifts" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2616891..2616910 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2616933..2617919 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /EC_number="1.1.1.371" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12450853, 28043209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450853, 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol dehydrogenase (NADP+-dependent);biofilm formation" /protein_id="NP_390995.1" /db_xref="EnsemblGenomes-Gn:BSU31170" /db_xref="EnsemblGenomes-Tr:CAB15095" /db_xref="GOA:O05265" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12388" /db_xref="UniProtKB/Swiss-Prot:O05265" /translation="MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAA KHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKE TEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFR SGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILS YDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPK PAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQA*" /label="iolU CDS" gene 2616933..2617919 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /label="iolU gene" downshifts 2617890 /Source="Nicolas_upshifts" /id="D1614" /incds=0 /nref=30 /ntot=279 /MaxReadThrough="1.83109" /MaxDrop="4.96985" /score="21.8997198" /energy="-15.1" /TU="NA" /idTUdmin="U2420" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2617960..2619234) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /EC_number="5.3.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose isomerase" /protein_id="NP_390996.1" /db_xref="EnsemblGenomes-Gn:BSU31180" /db_xref="EnsemblGenomes-Tr:CAB15096" /db_xref="GOA:O05264" /db_xref="InterPro:IPR009308" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG12387" /db_xref="UniProtKB/Swiss-Prot:O05264" /translation="MTIKANYDSAKQAYEKWGIDVEEALRQLEQVPISIHCWQGDDIE GFEVNKGELSGGIDVTGNYPGKAQTPEELRRDLEKALSLIPGKHRVNLHAIYAETNRE AVERDELKPQHFENWVKWAKNLGLGLDFNPTLFSHEKAADGLTLSHPDPDIREFWIRH CIACRRIGEYFGKELGTPCLTNIWIPDGYKDIPSDRLTPRKRLKESLDRIFSEEISEQ HNLDSIESKLFGLGSESYVVGSHEFYLAYALTNHKLCLLDTGHFHPTETVSNKISSML LYTDKLALHVSRPVRWDSDHVVVLDDELREIALEIVRNHALEKVAIGLDFFDASINRV AAWTIGTRNMIKALLYALLLPNGYLKQLQEEGRYTERLALMEEFKTYPFGAIWDSYCE QMGVPVKEAWLYDIKEYEQQVLLKRKASSPIV*" /label="rhaA CDS" gene complement(2617960..2619234) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /label="rhaA gene" downshifts complement(2617973) /Source="Nicolas_upshifts" /id="D1615" /incds=0 /nref=3 /ntot=29 /MaxReadThrough="0.802" /MaxDrop="4.45322" /score="14.0829844" /energy="-12.6" /TU="NA" /idTUdmin="U2421" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2619260..2619574) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /EC_number="5.1.3.32" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15576793, 15876375, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576793, 15876375, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose mutarotase" /protein_id="NP_390997.1" /db_xref="EnsemblGenomes-Gn:BSU31190" /db_xref="EnsemblGenomes-Tr:CAB15097" /db_xref="GOA:O05263" /db_xref="InterPro:IPR008000" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR013448" /db_xref="SubtiList:BG12386" /db_xref="UniProtKB/Swiss-Prot:O05263" /translation="MKRKASIMFVHQDKYEEYKQRHDDIWPEMAEALKAHGAHHYSIF LDEETGRLFAYLEIEDEEKWRKMADTEVCQRWWKSMAPLMKTNSDFSPVAIDLKEVFY LD*" /label="rhaM CDS" gene complement(2619260..2619574) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /label="rhaM gene" CDS complement(2619592..2621049) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /EC_number="2.7.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16674975, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16674975, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnulokinase" /protein_id="NP_390998.1" /db_xref="EnsemblGenomes-Gn:BSU31200" /db_xref="EnsemblGenomes-Tr:CAB15098" /db_xref="GOA:O05262" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR013449" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG12385" /db_xref="UniProtKB/Swiss-Prot:O05262" /translation="MIYTAIDVGASSGRIMVGELNEGKLDIQEIHRFANGFSQRDGHC LWDIDHLLKQILQGLQKVKTLGYEHCTVGIDTWAVDYVLLDEKGDRLREAISYRDRRT DHTIDKLEHTLSKAAIYQKTGIQFQPFNTIYQLFEEDRELLKKTDKIMMIPDYLGYCL TGKAVTEITNVSTTQLLNVSTGNLDPELLEAVSVLEQQFAPLTEPGCELGKLRNEWFP DYDLPACKVMTVATHDTASAVIAAPGVNDGWAYISSGTWSLIGVENKTPIITDLALEN NYTNERGANNTIRFLKNIIGMWVIQEVKQQLQADYSFQQLAEEAKKTEPFQQFINLND KRFLNPENMIKEIQHYCRQTRQKIPRTAGELACCIYSNLAIIYAIAIKELETITEKPI EQFHIIGGGARNDFLNQLTADMSGKAVYAGPIEATATGNLLMQMIAAKEVKDIKEARQ VVRNSFPIKVFTPKDIDRSTIIQSFQQTVLKALSK*" /label="rhaB CDS" gene complement(2619592..2621049) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /label="rhaB gene" CDS complement(2621054..2621830) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11496004, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11496004, 26712933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the rhamnose operon(RhaR / l-rhamnulose-1-phosphate)" /protein_id="NP_390999.1" /db_xref="EnsemblGenomes-Gn:BSU31210" /db_xref="EnsemblGenomes-Tr:CAB15099" /db_xref="GOA:O05261" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12384" /db_xref="UniProtKB/Swiss-Prot:O05261" /translation="MLVAERQQKIVEIVNMRSSIRVSELSDIFSVTEETIRRDLEKLE KEHKLSRSHGGAVSIQQKESEIHFSEREITNVIEKKAIAHEAAKYVKSGDRIILDAST TAWYMAKILPDIELTVITNSMKAAIELSNKENISVISTGGILLEKSLSFAGPLAERSL ETYHVNKTFLSCKGFDVHNGMSDSNEWQALLKKRMIERSDQTILMADSSKWGNREFSH IASLQDVSRLITDSGLDPASVKALEDKKVKVTAVPLSKRG*" /label="rhaR CDS" gene complement(2621054..2621830) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /label="rhaR gene" misc_feature complement(2621864..2621883) /Source="Nicolas_upshift_promotors" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2621880) /Source="Nicolas_upshifts" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2621887..2623956) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /EC_number="1.1.1.-" /EC_number="4.1.2.19" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24391637, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24391637, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase" /protein_id="NP_391000.1" /db_xref="EnsemblGenomes-Gn:BSU31220" /db_xref="EnsemblGenomes-Tr:CAB15100" /db_xref="GOA:P40747" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR013454" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG10947" /db_xref="UniProtKB/Swiss-Prot:P40747" /translation="MVKHIWDSERAAQLPKGVEELVYRSNLIGSDRTVCNWGGGNTSM KTTEKDFRGREIEVMWVKGSGSDLATMKAHNFSGLKLDDIRPLIKRDQMPDEEMVDYL SHCMIDSKHPRPSIETLLHAFLPYKHVDHTHPDAIISICCADNGKQIAEDIYGNRFVW VPYVRPGFTLSKMIAEGVANNPHAELVLMEKHGLVTWGETSETCYQKTISIIQEAEQY INDRINQHEVFGGKRYQPLPEDKRKQILAGIMPVIRGAVSEEKKMILSYDDHDDVLEF VNSVQAPALSQIGAACPDHLVHTKRVPLYIDWNPETQDVHKLADLIKSGVETFTSEYQ AYFTRNQQDGDQIFESAPRVILIPGIGMVNTGKSYAMSKVSGALYRRAIAVMKGATAL GQFVSLHENESYHVEYWPLELYKLTLAPPEAEFSRKVALITGGAGGIGSAACRRFAAE GGHVIVADLNIEGAQKIAGEINDAYGKGRAMAVKMDVTKEEDVQSAFERAALAYGGID IVVNNAGLATSSPFDETSLKEWNLNMNVLGTGYFLVAREAFKQMKHQNRGGSMVFVGS KNSVYAGKNASAYSSVKALETHLARCIAAEGGEFGIRVNSVLPDAVLQGSAIWGSSWR EERAAAYGIEPDQLEEHYRKRTALLVNIYPEDIAEAIAFFASSKAEKTTGCMITVDGG VPAAFTR*" /label="rhaE CDS" gene complement(2621887..2623956) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /label="rhaE gene" promotor_-10 complement(2623989..2624008) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2624001) /Source="Nicolas_upshifts" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2624022..2624028) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2624094..2626082) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391001.1" /db_xref="EnsemblGenomes-Gn:BSU31230" /db_xref="EnsemblGenomes-Tr:CAB15101" /db_xref="GOA:P39217" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10862" /db_xref="UniProtKB/Swiss-Prot:P39217" /translation="MGKFIQWIKQPSISKPLIAAFLAVLILPVGVLAYFSYQSAWNAL DRELISSAKGNVEELNSTLQNKLEDKVKAIDYYSETVDKDILLGKNKTLLKEKFKQYT TLNDDVGAIYAASEDKKLYKYPDSGVPKGFDPTGRDWYKQAVAEKGQAVFSEPYTDEA TGDIVVTISKQLKDGSGVIALDLNLDEVLTASKRIKIGKEGFAFITTGNKKYIAHPTI KPGTTGSGDWTNQVYSKKEGSFEYTFEGKEKKMAFTTNKLTGWKIAGTYFVSELQDAS SPVLNTAVIILCVSIVIGGILILYIIRAITKPLRKLVSTSAKISSGDLTEVIDIHSKN EFGQLGESFNEMSASLRSVIGVIQTSVENVASSSEELTASAAQTSKATEHITLAIEQF SDGNEAQSEKLETSSNHLSQMNEGISKVAQASSTITKSSIQSSEAAGSGEKLVEHTVG QMKTIDQSVQKAEAVVKGLETKSQDITSILNVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIQEIVREISTSLSMFQSVNHEVKEGLQITDQ TAESFKQIYEMTTQISGELQNLNATVEQLSAGSQEVSSAVEDISAVAKESSAGIQDIA ASAEEQLASMEEISSSAETLANMAEELQDITKKFKIES*" /label="tlpB CDS" gene complement(2624094..2626082) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /label="tlpB gene" downshifts complement(2624113) /Source="Nicolas_upshifts" /id="D1616" /incds=0 /nref=108 /ntot=174 /MaxReadThrough="3.32915" /MaxDrop="6.75141" /score="18.7221191" /energy="-8.3" /TU="NA" /idTUdmin="U2423" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2626086..2626093 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2626103..2626121) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2626109..2626128 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2626116) /Source="Nicolas_upshifts" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="upshifts" upshifts 2626125 /Source="Nicolas_upshifts" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2626135..2626142) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2626191 /Source="Nicolas_upshifts" /id="D1617" /incds=0 /nref=4 /ntot=11 /MaxReadThrough="1.04089" /MaxDrop="4.2056" /score="13.4355481" /energy="-10.7" /TU="NA" /idTUdmin="U2424" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2626196..2628181) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 9721285, 12011078" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 9721285, 12011078; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391002.2" /db_xref="EnsemblGenomes-Gn:BSU31240" /db_xref="EnsemblGenomes-Tr:CAB15102" /db_xref="GOA:P39214" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10861" /db_xref="UniProtKB/Swiss-Prot:P39214" /translation="MKKILQLIKQRSITRKLLVSFLSILIIPVVILAIFAYQSASSSL DRQMMGSALENVQQLNEIINTSIGEKENSADYFSEWLTKEKYNAKSNASIAEKFSQYI SINKDVESIYTSDTKGHFTRYPDLPMPSGYNPVERDWYKKAVANKGKVVITDPYKTAS TNTMVVTIAQQTKDGSGVIAINMTIENLLKTTKKVNIGTQGYAFIMTKDKKVVAHPNE QSGTELKGDWLDKMLSADKGDFQYTMDGDKKKMAFDTNKLTGWKIGGTMYLDEIHEAA QPVLHLALIVLAAAIIIGIIVMTLIIRSITTPLKQLVGSSKRISEGDLTETIDIRSKD ELGELGKSFNNMASSLRSLIHAIQDSVDNVAASSEELTASAAQTSKATEHITLAIEQF SNGNEKQNENIETAAEHIYQMNDGLTNMAQASEVITDSSVQSTEIASEGGKLVHQTVG QMNVIDKSVKEAEQVVRGLETKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIIEIVKEINTSLGMFQSVNQEVQTGLDITDK TEMSFKRISEMTNQIAGELQNMSATVQQLSASSEEVSGASEHIASISKESSAHIQDIA ASAEEQLASMEEISSSAETLSSMAEELRDMTKRFKIE*" /label="mcpA CDS" gene complement(2626196..2628181) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /label="mcpA gene" downshifts complement(2626201) /Source="Nicolas_upshifts" /id="D1618" /incds=0 /nref=196 /ntot=232 /MaxReadThrough="3.11319" /MaxDrop="7.54297" /score="40.6270404" /energy="-13.6" /TU="U2425" /idTUdmin="U2425" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2628202..2628220) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2628217) /Source="Nicolas_upshifts" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2628219..2628306) /Source="Nicolas_S_feature" /locus_tag="new_3208192_3208279_c" /HighExp="GM 150, T0.0H, T-1.40H, T-0.40H, MG 150, T-5.40H, T-3.40H, T-1.10H, T-2.40H, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1190" promotor_-35 complement(2628234..2628241) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2628307..2630295) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871, 26522943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871, 26522943; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (membrane curvature dependent localisation)" /protein_id="NP_391003.1" /db_xref="EnsemblGenomes-Gn:BSU31250" /db_xref="EnsemblGenomes-Tr:CAB15103" /db_xref="GOA:P39216" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10860" /db_xref="UniProtKB/Swiss-Prot:P39216" /translation="MKKTLTTIRRSSIARRLIISFLLILIVPITALSVSAYQSAVASL DVQMTQSAKENVQILDHIIDDKISTTEKSLAYFSDWATAEKFQDKKKTELKQEFKQFI QMNDNVAAVFSSGKDGDFTRYPYADMPSDFNALERDWYKEAMANKGKTIVTEPYESIS SGKMVVTIARQTVDGSGVVAIDMKIDDLVTTAKGINIGKEGYAFILSQNKKVIAYSGE KAGTELKGDWVDKLYKDKSGDFEYTYKGKKKKMAFATSQTTGWKISGTMYANEIHDAA SRVLIMASIVLAIAIGAGMTAIYFVIRSITKPLRRIVASAEKISEGDLTETIEINSKD ELGVLSESFNHMAHSLRSLIHGIKDSVEHVASSSEELTASADQTSRATEHITMAIEQF SNGSESQSEKIETTTEQINEMNDGLAELARAAAVITETSADSTEVSSKGETLVQKTAG QMNTIDHSVKAAEQVVKGLEIKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIESLISEIVKEIHTSLNVLQSVNKEVETGLVMTDE TKQSFKHISQMTNQIASELQNMNATVEELSAGAQEISAASNDITAISKESSDGIQDIA ASAEEQLASMEEISSSALTLERMSEELRDLTKQFKVDK*" /label="tlpA CDS" gene complement(2628307..2630295) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /label="tlpA gene" promotor_-10 complement(2630320..2630338) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-10" upshifts complement(2630335) /Source="Nicolas_upshifts" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="upshifts" promotor_-35 complement(2630352..2630359) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-35" CDS complement(2630472..2632460) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391004.2" /db_xref="EnsemblGenomes-Gn:BSU31260" /db_xref="EnsemblGenomes-Tr:CAB15104" /db_xref="GOA:P39215" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10859" /db_xref="UniProtKB/Swiss-Prot:P39215" /translation="MKTFINWLKKPSISKKLIVSFIAILIIPILILEFSSYRSASGKL DQEIMGNAKNSVDTFNTTVTNDLGEKAKAVTFFSESLKRSAFKGKSNQEEIKAKFSQY VSINQGVARIYGGADNGTYVQAPKEKLPEGYDPRQRPWYQDAMKAGGEIVVTDPYVAA SDGSMVITIAQELKDGSGVVAMDITIDKLLEQMKQIKVGKEGYAFIATKNKTYVAHKN HKAGEKLSGDWVAKMYANDSGELQYTLNNEDKKMTYTTNELTGWKIAGTMYMDEIKDA SKSVLTTGMIVLIASIVAGGILILFIVRSITKPLKRLVQSSKTISRGDLTETIEIHSK DELGELGESFNEMGQSLRSLISAIQDSVNNVAASSEQLTASAGQTSKATEHITMAIEQ FSNGNEEQSEKVESSSHQLNLMNEGLQQVSQTSSDITKASIQSTEIAGTGEKFVQQTV GQMNSINQSVQQAEAVVKGLEGKSKDITSILRVINGIADQTNLLALNAAIEAARAGES GRGFSVVAEEVRKLAVQSADSAKEIEKLIQEIVAEIDTSLHMFKEVNQEVQSGLVVTD NTKESFQSIFSMTNEIAGKLQTMNSTVEQLSDRSQHVSAAVSGIADVSKESSASIQDI AASAEEQLASMEEISSSATTLAQMAEELRDLTKQFKIE*" /label="mcpB CDS" gene complement(2630472..2632460) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /label="mcpB gene" downshifts complement(2630491) /Source="Nicolas_upshifts" /id="D1619" /incds=0 /nref=136 /ntot=224 /MaxReadThrough="3.76161" /MaxDrop="7.09773" /score="30.8363643" /energy="-10.7" /TU="U2427" /idTUdmin="U2427" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2632481..2632499) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2632502) /Source="Nicolas_upshifts" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2632512..2632519) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2632562..2632571 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2632585..2632604 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2632588 /Source="Nicolas_upshifts" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="upshifts" CDS 2632618..2633355 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /EC_number="2.3.2.13" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9692191, 16267299, 16751597, 16936016, 18249137, 26322858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9692191, 16267299, 16751597, 16936016, 18249137, 26322858; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein-glutamine gamma-glutamyltransferase (transglutaminase)" /protein_id="NP_391005.1" /db_xref="EnsemblGenomes-Gn:BSU31270" /db_xref="EnsemblGenomes-Tr:CAB15105" /db_xref="GOA:P40746" /db_xref="InterPro:IPR020916" /db_xref="PDB:4P8I" /db_xref="PDB:4PA5" /db_xref="SubtiList:BG10946" /db_xref="UniProtKB/Swiss-Prot:P40746" /translation="MIIVSGQLLRPQDIENWQIDQDLNPLLKEMIETPVQFDYHSIAE LMFELKLRMNIVAAAKTLHKSGAKFATFLKTYGNTTYWRVSPEGALELKYRMPPSKAI RDIAENGPFYAFECATAIVIIYYLALIDTIGEDKFNASFDRIILYDWHYEKLPIYTET GHHFFLGDCLYFKNPEFDPQKAQWRGENVILLGEDKYFAHGLGILNGKQIIDKLNSFR KKGALQSAYLLSQATRLDVPSLFRIVR*" /label="tgl CDS" gene 2632618..2633355 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /label="tgl gene" promotor_-10 complement(2632643..2632662) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-10" upshifts complement(2632651) /Source="Nicolas_upshifts" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="upshifts" promotor_-35 complement(2632678..2632682) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-35" S_feature 2633356..2636176 /Source="Nicolas_S_feature" /locus_tag="new_3213329_3216149" /HighExp="S6, S8, S7, BT, S5, C30, B36, Pyr, BC, C90" /AntisenseName="yugT" /AntisenseCor="0.63350809138227804" /AntisenseRegPval="-30.9" /CDS_PredictionProba="0.61985900000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1191" CDS complement(2633369..2633623) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097776.1" /db_xref="EnsemblGenomes-Gn:BSU31279" /db_xref="EnsemblGenomes-Tr:CAX52682" /db_xref="UniProtKB/Swiss-Prot:C0H3Q3" /translation="MNILQYSYKKRGKIEFVFEGWPHSKVTMVPIKGYYFVRFIKWSS QDPIVTRNDLEKMEWAANQYFGTAPFYRKRKAFETPSSGK*" /label="yuzH CDS" gene complement(2633369..2633623) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /label="yuzH gene" downshifts complement(2633395) /Source="Nicolas_upshifts" /id="D1620" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="2.39206" /MaxDrop="2.92958" /score="-2.51333596" /energy="-14.7" /TU="NA" /idTUdmin="U2430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2633624..2633880) /Source="Nicolas_S_feature" /locus_tag="new_3213597_3213853_c" /HighExp="Etha, Sw, Salt, Gly, BC, M9-stat, Lbstat, Heat, LPhT, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37980700000000001" /TUshortSig="SigB" /TUshortPSig="0.969" /TUlongSig="NA" /TUlongPSig="NA" /label="S1192" CDS complement(2633881..2634279) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391006.2" /db_xref="EnsemblGenomes-Gn:BSU31280" /db_xref="EnsemblGenomes-Tr:CAB15106" /db_xref="InterPro:IPR001602" /db_xref="InterPro:IPR035917" /db_xref="SubtiList:BG12373" /db_xref="UniProtKB/Swiss-Prot:O05243" /translation="MLKTLQIKTTKRDEMIDITREVEAFLQETGITSGAALIYCPHTT AGITINENADPDVKKDMLRRFDEVYPWEHELDRHMEGNTAAHMKSSTVGASQHVIVEN GRLILGTWQGIYFCEFDGPRTRTCYIKMMG*" /label="yugU CDS" gene complement(2633881..2634279) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /label="yugU gene" CDS complement(2634239..2634373) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514000.1" /translation="MFYRVYESGLTGKKRTQNELSDESGQTKGETNAENTANQNNQTR *" /label="hypothetical protein CDS" gene complement(2634239..2634373) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /label="gene" promotor_-10 complement(2634322..2634341) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2634329) /Source="Nicolas_upshifts" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2634356..2634362) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2634399..2636063) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1761534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-1,6-glucosidase" /protein_id="NP_391007.2" /db_xref="EnsemblGenomes-Gn:BSU31290" /db_xref="EnsemblGenomes-Tr:CAB15118" /db_xref="GOA:O05242" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG12372" /db_xref="UniProtKB/Swiss-Prot:O05242" /translation="MKKAWWKEAVVYQIYPRSFKDSNGDGIGDIQGIRTKLSYIKELG ADVIWICPLYDSPNADNGYDIRDYQNILSEFGTMEDFDELLGDIHDLDMKLIMDLVVN HTSDEHPWFIESRSSIHSEKRDWYIWKDGKNGKTPNNWESIFGGPAWEYDQKTSQYYL HLFDKKQPDLNWENEKVRNAVYDMINWWLDKGIDGFRVDAITHIKKKEGFPDMPNPKG LDYVPSFPYHMNADGIMDLLTELKENTFSRYPIMTVGEANGVAAKEAADWAGEKNGIF SMIFQFEHLGLWDVEINESIDIVAFKRILTDWQDSLEGIGWNALFMENHDQPRSVSVW GDDGVYLKESAKALSAVYFLMKGTPFIYQGQELGMTNVAFPSIEDYDDVALKRLYETK TAKGTSHEDVMKIVWKKGRDNSRTPMQWNAGPYAGFSEAKPWIGINENYKWLNAEAQK NDKTSVYHFYKSLIKLRQTYDVFINGTYELILPEDQQIFAYLRKNESHTALIAANLTG TPALFRHSGLPLSSDALVLSNIETEPHKHMTSVLLKPYEARIYLWC*" /label="yugT CDS" gene complement(2634399..2636063) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /label="yugT gene" downshifts complement(2634415) /Source="Nicolas_upshifts" /id="D1621" /incds=0 /nref=13 /ntot=38 /MaxReadThrough="1.79723" /MaxDrop="4.64379" /score="19.4176812" /energy="-6.5" /TU="NA" /idTUdmin="U2432" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2635371..2635390) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2635376) /Source="Nicolas_upshifts" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2635404..2635411) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2636088..2636106) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2636105) /Source="Nicolas_upshifts" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2636122..2636127) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2636190..2637479) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_391008.2" /db_xref="EnsemblGenomes-Gn:BSU31300" /db_xref="EnsemblGenomes-Tr:CAB15119" /db_xref="GOA:O05241" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12371" /db_xref="UniProtKB/Swiss-Prot:O05241" /translation="MLILQLIAIFVLIGITAVFVAAEFAIVKIRGSKINQLIESGDSR ALAAHKIISNLDEYLSACQLGITITALGLGWLGEPTFERFLHPLFTMTGIPEPFNHIV TFVVAFIIVTFLHVVMGELAPKTVSIQKAEAVSLWIAKPLIWFYKITYPFIKALNGSA SFLVKLFGFHSVKEHQVVISEEELRLILSESYEKGEINQSEFRYVNKIFEFDNRVARE IMIPRTEIAVISLEQSLEEAIHHIINERYTRYPVIKDDKDHILGIINSKDMFKAYFLG QPIKLNQIMRPVIRVIESIPVQQLLIRMQKERIHMAILVDEYGGTAGLVTVEDIIEEI VGEIRDEYDQDETPHILKKGEHHYVMDGKALIDEVNDLLDIAIENEEIDTIAGWLLTQ KMELKAGDVIHAEGCEFKILDAEDHHIRFVEIKKTDF*" /label="yugS CDS" gene complement(2636190..2637479) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /label="yugS gene" downshifts complement(2636199) /Source="Nicolas_upshifts" /id="D1622" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.89237" /MaxDrop="3.67001" /score="3.60520478" /energy="-7.6" /TU="NA" /idTUdmin="U2434" /TUdmin=13 /isTUend="TRUE" /label="downshifts" promotor_-35 2637008..2637014 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2637028..2637046 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2637034 /Source="Nicolas_upshifts" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="upshifts" S_feature 2637038..2637690 /Source="Nicolas_S_feature" /locus_tag="new_3217011_3217663" /HighExp="Etha, Sw, Gly, Salt, BC, B60, Heat, S8, B36, HiTm" /AntisenseName="yugS" /AntisenseCor="0.12310225183111501" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1193" CDS complement(2637523..2638200) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16704729, 16850406, 24383880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent protease/peptidase" /protein_id="NP_391009.1" /db_xref="EnsemblGenomes-Gn:BSU31310" /db_xref="EnsemblGenomes-Tr:CAB15120" /db_xref="GOA:O05248" /db_xref="InterPro:IPR007395" /db_xref="SubtiList:BG12370" /db_xref="UniProtKB/Swiss-Prot:O05248" /translation="MLFIFLTIAALGLSFWAQFKVKSNFEKYSKVEASSGRTGAETAR RILDINGLYDVPVEPVRGTLTDHYDPTRRVVRLSEPVYYGRSISAISVASHEVGHALQ HQESYGALVLRHKIFPVVNFASGVAPLLFLGGMLLGSLNLIGLGIILFSAAVFFQLIT LPVEFNASSRAKQIIVSEGFIRNNEENGVNKVLSAAALTYVAAALVSLFELLRFVMIF LNGRDEN*" /label="yugP CDS" gene complement(2637523..2638200) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /label="yugP gene" downshifts complement(2637533) /Source="Nicolas_upshifts" /id="D1623" /incds=0 /nref=153 /ntot=249 /MaxReadThrough="3.51629" /MaxDrop="4.854" /score="33.0420688" /energy="-13" /TU="U2434,U2435" /idTUdmin="U2435" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" S_feature 2637875..2638551 /Source="Nicolas_S_feature" /locus_tag="new_3217848_3218524" /HighExp="Sw, S8, Salt, BC, S7, Etha, Gly, B36, B60, LPhT" /AntisenseName="yuzI" /AntisenseCor="0.20035821815170399" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1194" promotor_-10 complement(2638235..2638254) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2638242..2638505) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16704729; Product type f : factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097777.1" /db_xref="EnsemblGenomes-Gn:BSU31319" /db_xref="EnsemblGenomes-Tr:CAX52683" /db_xref="GOA:C0H3Q4" /db_xref="UniProtKB/Swiss-Prot:C0H3Q4" /translation="MTIFQRTIVVLIGTQLAASAVILFIFDLNSYNHFSGSFSWLHFL KELAGSFAFYLFSAGLFFLLIGLCAPSRKKKRISVHEKENSLK*" /label="yuzI CDS" gene complement(2638242..2638505) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /label="yuzI gene" upshifts complement(2638256) /Source="Nicolas_upshifts" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2638268..2638275) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2638517..2638535) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2638531) /Source="Nicolas_upshifts" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2638551..2638556) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2638552..2638884 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15731457, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15731457, 23737939, 25297828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="atypical membrane-integrating regulator of biofilm formation (Mistic protein)" /protein_id="YP_003097778.1" /db_xref="EnsemblGenomes-Gn:BSU31321" /db_xref="EnsemblGenomes-Tr:CAX52684" /db_xref="GOA:Q5BU39" /db_xref="InterPro:IPR021078" /db_xref="PDB:1YGM" /db_xref="UniProtKB/Swiss-Prot:Q5BU39" /translation="MFCTFFEKHHRKWDILLEKSTGVMEAMKVTSEEKEQLSTAIDRM NEGLDAFIQLYNESEIDEPLIQLDDDTAELMKQARDMYGQEKLNEKLNTIIKQILSIS VSEEGEKE*" /label="mstX CDS" gene 2638552..2638884 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /label="mstX gene" promotor_-35 2638569..2638575 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2638590..2638607 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2638601 /Source="Nicolas_upshifts" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="upshifts" CDS 2638881..2639867 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16704729, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16704729, 23737939, 25297828; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium channel protein involved in biofilm formation" /protein_id="NP_391010.3" /db_xref="EnsemblGenomes-Gn:BSU31322" /db_xref="EnsemblGenomes-Tr:CAB15121" /db_xref="GOA:Q795M8" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR013099" /db_xref="InterPro:IPR028325" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12369" /db_xref="UniProtKB/Swiss-Prot:Q795M8" /translation="MKSNRIFISWLRWPLFIRIGVIILCLILLFGQIIYILEPKQFTS VFEGIWWAVVTVSTVGYGDYVPHTPLGQAAGILLILSGASFVTAYFATLSAAAFSRQH RYIEGKVAYKGRDHIILIGWNEKTNRLLKDLQLAAPSKTVVLIDESLTEGPLIENVHF IRGHAADDGTLKRANITEAESVMITADQYKSETDADMLSVLTLLSVKGLNPLAYCIVE ILTDRFVTNAERAGANQIIGTSEFISRAMLQHYQVKLRPSKQQNGIKLTLDQHVELLA VPDELKGAAYKTCVLYFLDHNTTIIGIQKKEGPMLSPPLTYKVLETDQFLAI*" /label="kbfO CDS" gene 2638881..2639867 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /label="kbfO gene" downshifts complement(2639842) /Source="Nicolas_upshifts" /id="D1624" /incds=0 /nref=44 /ntot=128 /MaxReadThrough="0.617940000000001" /MaxDrop="4.76695" /score="21.5904825" /energy="-11.3" /TU="NA" /idTUdmin="U2437" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2639864..2640268) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391011.1" /db_xref="EnsemblGenomes-Gn:BSU31330" /db_xref="EnsemblGenomes-Tr:CAB15122" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG12368" /db_xref="UniProtKB/Swiss-Prot:O05246" /translation="MIPIPSAIDGQSFLLQELEQVMKPLGYVINGGWEYDHGYFDYKI DDRDGYLFLRIPVNAVQGSLDERGAAVRIGTPFMLRQVFQADVDDHAEGGPFQSLFNQ FSEPERRDAEIDPAFLDIGASLVKELEDVLLH*" /label="yugN CDS" gene complement(2639864..2640268) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /label="yugN gene" S_feature complement(2640269..2640327) /Source="Nicolas_S_feature" /locus_tag="new_3220242_3220300_c" /HighExp="M0t90, M40t90, S6, S8, S7, T0.30H, Lbstat, M9-stat, T1.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-, SigA" /TUshortPSig="0.686, 0.141, 0.984" /TUlongSig="SigA" /TUlongPSig="0.988" /label="S1195" CDS complement(2640328..2640699) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391012.1" /db_xref="EnsemblGenomes-Gn:BSU31340" /db_xref="EnsemblGenomes-Tr:CAB15123" /db_xref="GOA:O05245" /db_xref="SubtiList:BG12367" /db_xref="UniProtKB/Swiss-Prot:O05245" /translation="MFMKQLVKHLIIAGFSAAILSFLISFDAVYTGFSSSFGGTLSHF FIHSFLLIGLPLALFTDAVHRILHLKRTHTLFTKLGLYATVVYVSWDSAVWLAAAMAV YFLIECAFFPVGRAKETTISM*" /label="yugM CDS" gene complement(2640328..2640699) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /label="yugM gene" CDS complement(2640758..2642110) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /EC_number="5.3.1.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4214896, 4275311, 11489127, 19052382, 21453533, 22720735, 24705866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate isomerase" /protein_id="NP_391013.2" /db_xref="EnsemblGenomes-Gn:BSU31350" /db_xref="EnsemblGenomes-Tr:CAB15124" /db_xref="GOA:P80860" /db_xref="InterPro:IPR001672" /db_xref="InterPro:IPR018189" /db_xref="InterPro:IPR035476" /db_xref="InterPro:IPR035482" /db_xref="SubtiList:BG12366" /db_xref="UniProtKB/Swiss-Prot:P80860" /translation="MTHVRFDYSKALTFFNEHELTYLRDFVKTAHHNIHEKTGAGSDF LGWVDLPEHYDKEEFARIKKSAEKIKSDSDVLLVVGIGGSYLGARAAIEALNHAFYNT LPKAKRGNPQVIFIGNNISSSYMRDVMDLLEDVDFSINVISKSGTTTEPAIAFRIFRK LLEEKYGKEEAKARIYATTDKERGALKTLSNEEGFESFVIPDDVGGRYSVLTAVGLLP IAVSGVNIDDMMKGALDASKDFATSELEDNPAYQYAVVRNVLYNKGKTIEMLINYEPA LQYFAEWWKQLFGESEGKDEKGIYPSSANYSTDLHSLGQYVQEGRRDLFETVLNVEKP KHELTIEEADNDLDGLNYLAGKTVDFVNKKAFQGTMLAHTDGNVPNLIVNIPELNAYT FGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELEKRLED *" /label="pgi CDS" gene complement(2640758..2642110) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /label="pgi gene" downshifts complement(2640769) /Source="Nicolas_upshifts" /id="D1625" /incds=0 /nref=90 /ntot=198 /MaxReadThrough="6.86736" /MaxDrop="4.4585" /score="24.139293" /energy="-16.8" /TU="U2437,U2438,U2439" /idTUdmin="U2441" /TUdmin=19 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2640925..2640943) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2640942) /Source="Nicolas_upshifts" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2640959..2640964) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2642083) /Source="Nicolas_upshifts" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2642086..2642097) /Source="Nicolas_upshift_promotors" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2642142..2642161) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2642148) /Source="Nicolas_upshifts" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2642150..2642221) /Source="Nicolas_S_feature" /locus_tag="new_3222123_3222194_c" /HighExp="Etha, H2O2, Paraq, Oxctl, G180, G150, dia5, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.988" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1196" promotor_-35 complement(2642176..2642179) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2642222..2643394) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 1809209, 2673038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase subunit" /protein_id="NP_391014.1" /db_xref="EnsemblGenomes-Gn:BSU31360" /db_xref="EnsemblGenomes-Tr:CAB15125" /db_xref="GOA:O05240" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12365" /db_xref="UniProtKB/Swiss-Prot:O05240" /translation="MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKR NGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVID CTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEK FVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCF AVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAV YDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSA FWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL*" /label="bdhK CDS" gene complement(2642222..2643394) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /label="bdhK gene" S_feature 2642557..2643478 /Source="Nicolas_S_feature" /locus_tag="new_3222530_3223451" /HighExp="S6, S7, S8, BT, S5, C30, LBGstat, B36, G135, G150" /AntisenseName="yugK" /AntisenseCor="4.31382473780575E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1197" promotor_-10 complement(2643427..2643446) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-10" upshifts complement(2643440) /Source="Nicolas_upshifts" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="upshifts" promotor_-35 complement(2643463..2643466) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-35" CDS complement(2643498..2644661) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 2673038, 9643546, 11466286, 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase" /protein_id="NP_391015.1" /db_xref="EnsemblGenomes-Gn:BSU31370" /db_xref="EnsemblGenomes-Tr:CAB15126" /db_xref="GOA:O05239" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12364" /db_xref="UniProtKB/Swiss-Prot:O05239" /translation="MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKR SGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVID CTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEK YGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCE SLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAV YDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSA FWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL*" /label="bdhJ CDS" gene complement(2643498..2644661) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /label="bdhJ gene" downshifts complement(2643513) /Source="Nicolas_upshifts" /id="D1626" /incds=0 /nref=167 /ntot=237 /MaxReadThrough="6.69366" /MaxDrop="4.74696" /score="28.8200012" /energy="-13.4" /TU="U2441" /idTUdmin="U2444" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2644676..2644695) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-10" upshifts complement(2644694) /Source="Nicolas_upshifts" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="upshifts" S_feature complement(2644696..2644851) /Source="Nicolas_S_feature" /locus_tag="new_3224669_3224824_c" /HighExp="S8, S7, S4, S5, S6, LoTm, Cold, LBGtran, G180, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25658199999999998" /TUshortSig="SigGF, SigA" /TUshortPSig="0.679, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1198" promotor_-35 complement(2644710..2644717) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-35" promotor_-35 2644747..2644753 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2644768..2644786 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2644778 /Source="Nicolas_upshifts" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2644779..2644837 /Source="Nicolas_S_feature" /locus_tag="new_3224752_3224810" /HighExp="Etha, Salt, Heat, M9-stat, LPhT, Sw, Gly, BC, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1199" promotor_-35 2644824..2644830 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2644826..2644837) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2644839 /Source="Nicolas_upshifts" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2644844..2644855 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2644851..2644857) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2644851) /Source="Nicolas_upshifts" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2644853..2645164) /Source="Nicolas_S_feature" /locus_tag="new_3224826_3225137_c" /HighExp="Cold, LBGtran, LoTm, G180, LBGexp, dia15, G135, H2O2, Paraq, Oxctl" /AntisenseName="yuzA" /AntisenseCor="-0.50065532030853999" /AntisenseRegPval="-17.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1200" CDS 2644891..2645127 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391016.1" /db_xref="EnsemblGenomes-Gn:BSU31380" /db_xref="EnsemblGenomes-Tr:CAB15127" /db_xref="GOA:O32087" /db_xref="InterPro:IPR007211" /db_xref="SubtiList:BG14050" /db_xref="UniProtKB/Swiss-Prot:O32087" /translation="MSTIQRICLVLTIIGAINWGLIGFFQFDLVAAIFGGQGSALSRI IYGLVGIAGLINLGLLFKPNEERSREEAANPEMR*" /label="yuzA CDS" gene 2644891..2645127 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /label="yuzA gene" downshifts 2645087 /Source="Nicolas_upshifts" /id="D1627" /incds=0 /nref=3 /ntot=45 /MaxReadThrough="7.39676" /MaxDrop="2.87922" /score="13.9936296" /energy="-12" /TU="U2442,U2443" /idTUdmin="U2442" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2645153 /Source="Nicolas_upshifts" /id="D1628" /incds=0 /nref=25 /ntot=56 /MaxReadThrough="1.29261" /MaxDrop="7.50276" /score="13.9936296" /energy="-12" /TU="NA" /idTUdmin="U2442" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2645205..2645597) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 16014871, 19152054, 19636895; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; putative phosphorylase or nucleotidyl transferase; general stress protein" /protein_id="NP_391017.1" /db_xref="EnsemblGenomes-Gn:BSU31390" /db_xref="EnsemblGenomes-Tr:CAB15128" /db_xref="GOA:P80870" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="PDB:2K4K" /db_xref="SubtiList:BG12363" /db_xref="UniProtKB/Swiss-Prot:P80870" /translation="MAAKFEVGSVYTGKVTGLQAYGAFVALDEETQGLVHISEVTHGF VKDINEHLSVGDEVQVKVLAVDEEKGKISLSIRATQAAPEKKESKPRKPKAAQVSEEA STPQGFNTLKDKLEEWIEMSNRKDLIKK*" /label="yugI CDS" gene complement(2645205..2645597) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /label="yugI gene" downshifts complement(2645209) /Source="Nicolas_upshifts" /id="D1629" /incds=0 /nref=232 /ntot=268 /MaxReadThrough="5.9665" /MaxDrop="6.0195" /score="13.5952751" /energy="-15.6" /TU="U2445" /idTUdmin="U2448" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2645639..2645658) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-10" upshifts complement(2645646) /Source="Nicolas_upshifts" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="upshifts" S_feature complement(2645648..2645798) /Source="Nicolas_S_feature" /locus_tag="new_3225621_3225771_c" /HighExp="G180, C30, G135, LBGexp, G150, Oxctl, HPh, Cold, BMM, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1201" promotor_-35 complement(2645674..2645678) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-35" promotor_-35 2645701..2645707 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2645714..2646698 /Source="Nicolas_S_feature" /locus_tag="new_3225687_3226671" /HighExp="LoTm, C30, Salt, S7, S5, S8, Sw, S3, C90, S6" /AntisenseName="yugH" /AntisenseCor="-0.45629591209076698" /AntisenseRegPval="-14.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.662" /TUlongSig="NA" /TUlongPSig="NA" /label="S1202" upshifts 2645714 /Source="Nicolas_upshifts" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2645722..2645740 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2645799..2646959) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /EC_number="2.6.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_391018.2" /db_xref="EnsemblGenomes-Gn:BSU31400" /db_xref="EnsemblGenomes-Tr:CAB15129" /db_xref="GOA:Q795M6" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12362" /db_xref="UniProtKB/Swiss-Prot:Q795M6" /translation="MTSYLSDYVQQIKPSGIRKFFDLAATMEGVISLGVGEPDFVTAW NVREASILSLEQGYTSYTANAGLYSLREEISRYLSNRFDLSYSPDNELIVTVGASQAL DIAIRAIVNPGEEVIIPEPCFVAYDALVSLAGGIPVHVHTTADKGFKATAADFEAAVT EKTKAILICSPSNPTGSVYSKEELNEIAEFAKKHDVIVLADEIYAELTYDEEFTSIAA LPGMKERTVVISGFSKAFAMTGWRLGFAAAPSLLRDAMLKIHQYAMMCAPAMAQFAAL EGLKNGMEDVEKMKKSYRRRRNLFVESLNEIGLSCHHPGGAFYAFPSIKSMGMSSEQF AEELLTQEKVAVVPGSVFGPSGEGYIRCSYATSIEQLQEALVRMKRFLHKTT*" /label="yugH CDS" gene complement(2645799..2646959) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /label="yugH gene" promotor_-35 2646851..2646857 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2646869 /Source="Nicolas_upshifts" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2646871..2646875 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2646960..2647460) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_391019.1" /db_xref="EnsemblGenomes-Gn:BSU31410" /db_xref="EnsemblGenomes-Tr:CAB15130" /db_xref="GOA:O05236" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12361" /db_xref="UniProtKB/Swiss-Prot:O05236" /translation="MKLTEKETEILEILDENSRADLETIAKMAGIPVNEVKTIIDKLE KEKVIIDYSAMIDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFQEVESVYLM SGVYDLSVVIRGNSMSDVARFVSDKLSTLDSVVSTTTHFILKKYKHDGKVFETGDDDK RIVVSP*" /label="yugG CDS" gene complement(2646960..2647460) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /label="yugG gene" promotor_-10 complement(2647490..2647509) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-10" promotor_-35 2647496..2647502 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2647511) /Source="Nicolas_upshifts" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="upshifts" promotor_-10 2647517..2647528 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2647517 /Source="Nicolas_upshifts" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2647520..2647527) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-35" S_feature 2647529..2647607 /Source="Nicolas_S_feature" /locus_tag="new_3227502_3227580" /HighExp="S8, S5, S6, S7, S4, C30, Glucon, Pyr, nit, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1203" CDS 2647608..2648429 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391020.1" /db_xref="EnsemblGenomes-Gn:BSU31420" /db_xref="EnsemblGenomes-Tr:CAB15131" /db_xref="GOA:O05235" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR013595" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12360" /db_xref="UniProtKB/Swiss-Prot:O05235" /translation="MEAVSPIRRFTVDGVNVYYEHYQNPGRQTLVCVHGFLSSAFSFR KVIPLLRDKYDIIALDLPPFGQSEKSRTFIYTYQNLAKLVIGILEHLQVKQAVLVGHS MGGQISLSAALQKPELFSKVVLLCSSGYLKRSHPTIIFGTHIPYFHLYIKRWLSKEGV MKNLLNVVHDKSLIDEEMIDGYGRPFQDEQIFKAMTRFIRHREGDLEPEQLKKMNKPA LLIWGEEDRIVPMEIGKRLHADLPNSVLYSLGQTGHLVPEERPELISEHIADFIK*" /label="yugF CDS" gene 2647608..2648429 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /label="yugF gene" downshifts 2648409 /Source="Nicolas_upshifts" /id="D1630" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="1.0929" /MaxDrop="3.08755" /score="11.2614618" /energy="-6.6" /TU="NA" /idTUdmin="U2449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2648456) /Source="Nicolas_upshifts" /id="D1631" /incds=0 /nref=20 /ntot=156 /MaxReadThrough="2.22671" /MaxDrop="4.10906" /score="25.9859375" /energy="-6.6" /TU="NA" /idTUdmin="U2451" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(2648458..2648718) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391021.2" /db_xref="EnsemblGenomes-Gn:BSU31430" /db_xref="EnsemblGenomes-Tr:CAB15132" /db_xref="InterPro:IPR015053" /db_xref="InterPro:IPR023162" /db_xref="SubtiList:BG12359" /db_xref="UniProtKB/Swiss-Prot:O05234" /translation="MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDP DLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP*" /label="yugE CDS" gene complement(2648458..2648718) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /label="yugE gene" promotor_-35 2648708..2648711 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-35" promotor_-10 2648726..2648745 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-10" upshifts 2648738 /Source="Nicolas_upshifts" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="upshifts" S_feature 2648739..2648804 /Source="Nicolas_S_feature" /locus_tag="new_3228712_3228777" /HighExp="dia15, dia5, Lbexp, dia0, LBGtran, G180, Diami, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1204" promotor_-10 complement(2648744..2648763) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2648749) /Source="Nicolas_upshifts" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2648775..2648781) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2648805..2649968 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /EC_number="4.4.1.1" /EC_number="4.4.1.13" /EC_number="4.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15760717, 26337367, 28895253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15760717, 26337367, 28895253; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous cystathionine / cystine beta-lyase /cysteine desulfhydrase" /protein_id="NP_391022.1" /db_xref="EnsemblGenomes-Gn:BSU31440" /db_xref="EnsemblGenomes-Tr:CAB15133" /db_xref="GOA:Q08432" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR027619" /db_xref="SubtiList:BG10744" /db_xref="UniProtKB/Swiss-Prot:Q08432" /translation="MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEA ITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAV QAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPS VTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASL SDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTA IEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLS DAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS*" /label="patB CDS" gene 2648805..2649968 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /label="patB gene" promotor_-35 2650031..2650037 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2650049..2650068 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2650059 /Source="Nicolas_upshifts" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2650094..2651380 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9426145, 11069677, 15849754, 16850406, 26152584, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 11069677, 15849754, 16850406, 26152584, 28583948; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-binding histidinekinase" /protein_id="NP_391023.2" /db_xref="EnsemblGenomes-Gn:BSU31450" /db_xref="EnsemblGenomes-Tr:CAB15134" /db_xref="GOA:Q08430" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10745" /db_xref="UniProtKB/Swiss-Prot:Q08430" /translation="MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLF ACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPS AMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNIL NFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAAS VAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQ LYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKN SIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGL TVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH*" /label="kinB CDS" gene 2650094..2651380 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /label="kinB gene" S_feature complement(2651096..2651838) /Source="Nicolas_S_feature" /locus_tag="new_3231069_3231811_c" /HighExp="BT, S8, B36, S6, S7, S5, S3, S4, Cold, Pyr" /AntisenseName="kapB" /AntisenseCor="-0.71681066342113797" /AntisenseRegPval="-43" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigK" /TUshortPSig="0.709, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1205" promotor_-35 2651375..2651382 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2651396..2651415 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2651397 /Source="Nicolas_upshifts" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2651426..2651812 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9426145, 23335417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 23335417; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for KinB signal transduction andactivation of the phosphorelay to sporulation" /protein_id="NP_391024.1" /db_xref="EnsemblGenomes-Gn:BSU31460" /db_xref="EnsemblGenomes-Tr:CAB15135" /db_xref="GOA:Q08429" /db_xref="InterPro:IPR014916" /db_xref="SubtiList:BG10746" /db_xref="UniProtKB/Swiss-Prot:Q08429" /translation="MSTFETGSIVKGFYKTGVYIGEITACRPQHYLVKVKAVLTHPAQ GDLHHPKQADVPFFHERKALAYGEQTNIPHHMVKPYDGEVPDYTESLREATAQMRAKL NEDGSEWAKRSLHNLDILEKEYFNRP*" /label="kapB CDS" gene 2651426..2651812 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /label="kapB gene" downshifts 2651794 /Source="Nicolas_upshifts" /id="D1632" /incds=0 /nref=209 /ntot=249 /MaxReadThrough="1.62013" /MaxDrop="5.57132" /score="1.97959632" /energy="-9.2" /TU="NA" /idTUdmin="U2452" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2651839..2652456) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27188294; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exoribonuclease (3'-5')" /protein_id="NP_391025.1" /db_xref="EnsemblGenomes-Gn:BSU31470" /db_xref="EnsemblGenomes-Tr:CAB15136" /db_xref="GOA:O05231" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12358" /db_xref="UniProtKB/Swiss-Prot:O05231" /translation="MTTNSLLIIDFEFTMPDGKYSPQNFFPEIIEAGIVKSIDDEVVE TFSSYVRPKKFPKLTKRCKSFLKITQKQVDEGMRFEDFIRKLNELDPEKNSTIITWGN MDMKVLKQNCMFNHIPFPFKGEMRDLSLEYKNFFGDRTLTGLWKAAEEYGDSGTGTHH KALDDALTAYKLFKLVEQDKQYLEKPKPPTIGERIDLTELLKRAT*" /label="kapD CDS" gene complement(2651839..2652456) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /label="kapD gene" promotor_-10 complement(2652491..2652509) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2652508) /Source="Nicolas_upshifts" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2652510..2654598) /Source="Nicolas_S_feature" /locus_tag="new_3232483_3234571_c" /HighExp="S8, BT, B36, S7, S6, Pyr, C30, B60, S5, G135" /AntisenseName="yuxJ" /AntisenseCor="-0.168930816447634" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1206" promotor_-35 complement(2652524..2652529) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2652572..2652575 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-35" promotor_-10 2652590..2652609 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-10" upshifts 2652601 /Source="Nicolas_upshifts" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="upshifts" CDS 2652667..2653845 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter induced in acid stress" /protein_id="NP_391026.2" /db_xref="EnsemblGenomes-Gn:BSU31480" /db_xref="EnsemblGenomes-Tr:CAB15137" /db_xref="GOA:P40760" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10976" /db_xref="UniProtKB/Swiss-Prot:P40760" /translation="MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGI TFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLV TGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFIT SFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTG NFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIG LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGY NVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS *" /label="yuxJ CDS" gene 2652667..2653845 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /label="yuxJ gene" promotor_-35 2653883..2653889 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2653901..2653920 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2653906 /Source="Nicolas_upshifts" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="upshifts" CDS 2653938..2655812 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /EC_number="2.-.-.-" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7961491, 9274030; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4" /protein_id="NP_391027.2" /db_xref="EnsemblGenomes-Gn:BSU31490" /db_xref="EnsemblGenomes-Tr:CAB15138" /db_xref="GOA:P40750" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10977" /db_xref="UniProtKB/Swiss-Prot:P40750" /translation="MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKN IDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYE HKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQL EKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTL YDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYV NDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQ VVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKP LLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIR MLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSY TPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPY IGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY *" /label="pbpD CDS" gene 2653938..2655812 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /label="pbpD gene" promotor_-10 complement(2654578..2654597) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2654598) /Source="Nicolas_upshifts" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2654611..2654620) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2655833..2656246 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26335199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase" /protein_id="NP_391028.1" /db_xref="EnsemblGenomes-Gn:BSU31500" /db_xref="EnsemblGenomes-Tr:CAB15139" /db_xref="InterPro:IPR007263" /db_xref="SubtiList:BG10978" /db_xref="UniProtKB/Swiss-Prot:P40761" /translation="MTSEQIPNRVLLFDGVCNLCNGAVQFIIKRDPDGLISFTSLQSE TGQSLLKKSGLPTDRFDSFVFIEDGQVYTKSTAAIKVFRHLRGPWRLFVLFFAVPKPV RDMVYSFIAKNRYKWFGKKNECMLPSPSIKKRFLP*" /label="yuxK CDS" gene 2655833..2656246 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /label="yuxK gene" downshifts 2656238 /Source="Nicolas_upshifts" /id="D1633" /incds=0 /nref=1 /ntot=254 /MaxReadThrough="5.05064" /MaxDrop="3.14634" /score="-3.58105315" /energy="-11.5" /TU="U2456" /idTUdmin="U2456" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2656449..2657006) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391029.2" /db_xref="EnsemblGenomes-Gn:BSU31510" /db_xref="EnsemblGenomes-Tr:CAB15140" /db_xref="GOA:O05249" /db_xref="InterPro:IPR035289" /db_xref="SubtiList:BG12346" /db_xref="UniProtKB/Swiss-Prot:O05249" /translation="MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGML DYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGS MIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLF WFTFVIGILFIFIKLYNSIMASLPV*" /label="yufK CDS" gene complement(2656449..2657006) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /label="yufK gene" misc_feature 2656470..2656489 /Source="Nicolas_upshift_promotors" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2656480 /Source="Nicolas_upshifts" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2656490) /Source="Nicolas_upshifts" /id="D1634" /incds=0 /nref=10 /ntot=201 /MaxReadThrough="3.90201" /MaxDrop="3.94501" /score="-6.00543052" /energy="-18.5" /TU="U2459" /idTUdmin="U2459" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 2656502..2657183 /Source="Nicolas_S_feature" /locus_tag="new_3236475_3237156" /HighExp="Diami, Cold, LBGstat, H2O2, Lbtran, Gly, M0t90, GM 10, GM-0.2, dia15" /AntisenseName="yufK" /AntisenseCor="0.32488342936044701" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.878" /TUlongSig="NA" /TUlongPSig="NA" /label="S1207" promotor_-10 complement(2657032..2657051) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2657040) /Source="Nicolas_upshifts" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2657067..2657071) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2657184..2658785 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [MaeM]" /protein_id="NP_391030.1" /db_xref="EnsemblGenomes-Gn:BSU31520" /db_xref="EnsemblGenomes-Tr:CAB15141" /db_xref="GOA:O05250" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12347" /db_xref="UniProtKB/Swiss-Prot:O05250" /translation="MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKA TALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPD PSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVN EIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAML ESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKK PLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALR AQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLG KQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMS MRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMI LTSEKNEGTTFSIRIPYEPKEENHD*" /label="maeL CDS" gene 2657184..2658785 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /label="maeL gene" CDS 2658778..2659485 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator for malate metabolism [MaeL]" /protein_id="NP_391031.1" /db_xref="EnsemblGenomes-Gn:BSU31530" /db_xref="EnsemblGenomes-Tr:CAB15142" /db_xref="GOA:O05251" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12348" /db_xref="UniProtKB/Swiss-Prot:O05251" /translation="MINVLIVEDDPMVGELNKRYLSQIDGFQLKGIASSFQSALHILG EHHIDLILLDIYMPGKNGLELLTELRAQNEAVDVIVISAASELDVIKKTLRYGAVDYL IKPFEFERFQTALSDYRRKQKVYSTHRNMSQKELDAELFQKKEATEKVQLPKGLTKST LKLIWSSIQSFENESFTTEDLAKHTEISQVSIRKYLKFLEDIQVLNVEMAYGTIGRPV FQYNVNNSNINGIKQYL*" /label="maeM CDS" gene 2658778..2659485 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /label="maeM gene" downshifts 2659470 /Source="Nicolas_upshifts" /id="D1635" /incds=0 /nref=173 /ntot=245 /MaxReadThrough="1.97489" /MaxDrop="5.86018" /score="19.9464971" /energy="-15.3" /TU="NA" /idTUdmin="U2458" /TUdmin=2660 /isTUend="FALSE" /label="downshifts" promotor_-35 2659649..2659656 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2659667..2659956 /Source="Nicolas_S_feature" /locus_tag="new_3239640_3239929" /HighExp="T1.30H, T1.0H, T2.30H, T2.0H, M9-stat, S1, T3.0H, T3.30H, T0.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1208" upshifts 2659667 /Source="Nicolas_upshifts" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2659671..2659690 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2659957..2661036 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in guanosine transport" /protein_id="NP_391032.2" /db_xref="EnsemblGenomes-Gn:BSU31540" /db_xref="EnsemblGenomes-Tr:CAB15143" /db_xref="GOA:O05252" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12349" /db_xref="UniProtKB/Swiss-Prot:O05252" /translation="MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMV TDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENF DLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAAL SSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAES MYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNV TLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVD KWKKKIIDGLEIPATEKELKTFKAE*" /label="nupN CDS" gene 2659957..2661036 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /label="nupN gene" CDS 2661112..2662644 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanosine ABC transporter (ATP-binding protein)" /protein_id="NP_391033.1" /db_xref="EnsemblGenomes-Gn:BSU31550" /db_xref="EnsemblGenomes-Tr:CAB15144" /db_xref="GOA:O05253" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12350" /db_xref="UniProtKB/Swiss-Prot:O05253" /translation="MEYVIEMLNIRKAFPGIVANDNINLQVKKGEIHALLGENGAGKS TLMNVLFGLYQPERGEIRVRGEKVHINSPNKANDLGIGMVHQHFMLVDTFTVAENIIL GKEPKKFGRIDRKRAGQEVQDISDRYGLQIHPEAKAADISVGMQQRAEILKTLYRGAD ILIFDEPTAVLTPHEIKELMQIMKNLVKEGKSIILITHKLKEIMEICDRVTVIRKGKG IKTLDVRDTNQDELASLMVGREVSFKTEKRAAQPGAEVLAIDGITVKDTRGIETVRDL SLSVKAGEIVGIAGVDGNGQSELIEAVTGLRKTDSGTITLNGKQIQNLTPRKITESGI GHIPQDRHKHGLVLDFPIGENILLQSYYKKPYSALGVLHKGEMYKKARSLITEYDVRT PDEYTHARALSGGNQQKAIIGREIDRNPDLLIAAQPTRGLDVGAIEFVHKKLIEQRDA GKAVLLLSFELEEIMNLSDRIAVIFEGRIIASVNPQETTEQELGLLMAGSTQKEAGKA NG*" /label="nupO CDS" gene 2661112..2662644 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /label="nupO gene" CDS 2662637..2663683 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391034.1" /db_xref="EnsemblGenomes-Gn:BSU31560" /db_xref="EnsemblGenomes-Tr:CAB15145" /db_xref="GOA:O05254" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR002229" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12351" /db_xref="UniProtKB/Swiss-Prot:O05254" /translation="MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGI FGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGP AYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLT DHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRA VGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDG IAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYA IRFVMGKLKKKGAN*" /label="nupP CDS" gene 2662637..2663683 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /label="nupP gene" CDS 2663684..2664643 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391035.1" /db_xref="EnsemblGenomes-Gn:BSU31570" /db_xref="EnsemblGenomes-Tr:CAB15146" /db_xref="GOA:O05255" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12352" /db_xref="UniProtKB/Swiss-Prot:O05255" /translation="MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGL MIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGV AINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSIL AIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGG VYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPL FKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR*" /label="nupQ CDS" gene 2663684..2664643 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /label="nupQ gene" S_feature 2664644..2664765 /Source="Nicolas_S_feature" /locus_tag="new_3244617_3244738" /HighExp="S1, BT, M9-stat, T1.30H, S2, LoTm, T1.0H, T2.30H, T2.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1209" promotor_-35 2664738..2664741 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2664756..2664775 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2664767 /Source="Nicolas_upshifts" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="upshifts" CDS 2664797..2666143 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/malate symporter" /protein_id="NP_391036.1" /db_xref="EnsemblGenomes-Gn:BSU31580" /db_xref="EnsemblGenomes-Tr:CAB15147" /db_xref="GOA:O05256" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12353" /db_xref="UniProtKB/Swiss-Prot:O05256" /translation="MGAIPKTGTISPEQKDSQEKNLFQKIWSWEIGVIPLPLYTVLAV IIILAAYYNELPANMLGGFAIIMILGVFLGDIGQRIPILKDIGGPAILSLFVPSFLVF YNVLNSTSLDAVTNLMKTSNFLYFYIACLVVGSILGMNRIVLIQGFIRMFVPLVAGTI AAVAAGILVGFIFGYSAYDSFFFVVVPIIAGGIGEGILPLSIAYSQILGSSADVFVSQ LVPAAIIGNVFAIICAALMKKLGDKRPDLNGNGRLVKSKKANEIFNQKEAEAKIDFKL MGAGVLLACTFFIFGGLLEKFIFIPGAILMIISAAAVKYANILPKKMEEGAYQLYKFI SSSFTWPLMVGLGILFIPLDDVASVISIPFVIICISVVIAMIGSGYFVGKLMNMYPVE SAIVTCCHSGLGGTGDVAILSASGRMGLMPFAQISTRLGGAGTVICATVLLRFFTS*" /label="maeN CDS" gene 2664797..2666143 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /label="maeN gene" downshifts 2666126 /Source="Nicolas_upshifts" /id="D1636" /incds=0 /nref=68 /ntot=109 /MaxReadThrough="0.286069999999999" /MaxDrop="6.51197" /score="36.240717" /energy="-12.2" /TU="NA" /idTUdmin="U2461" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(2666179..2666394) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391037.1" /db_xref="EnsemblGenomes-Gn:BSU31590" /db_xref="EnsemblGenomes-Tr:CAB15148" /db_xref="GOA:O05257" /db_xref="SubtiList:BG12354" /db_xref="UniProtKB/Swiss-Prot:O05257" /translation="MKTKVVMCSGLFCSVFAGAFMLNQYDGRSGVAACDEWELYLLEH HLSARMSETESKDLPFGPREYIRIVNK*" /label="yufS CDS" gene complement(2666179..2666394) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /label="yufS gene" promotor_-35 2666334..2666340 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2666354..2666365 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2666358 /Source="Nicolas_upshifts" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2666405..2666423) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2666412) /Source="Nicolas_upshifts" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2666437..2666444 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2666439..2666444) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2666459..2666554 /Source="Nicolas_S_feature" /locus_tag="new_3246432_3246527" /HighExp="G180, Diami, G150, Oxctl, G135, H2O2, Paraq, MG 60, MG 15, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1210" promotor_-10 2666459..2666478 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2666459 /Source="Nicolas_upshifts" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2666517..2666521 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2666537..2666556 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2666556..2666705 /Source="Nicolas_S_feature" /locus_tag="new_3246529_3246678" /HighExp="G135, G180, Diami, G150, H2O2, Oxctl, LBGexp, Paraq, Salt, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1211" upshifts 2666556 /Source="Nicolas_upshifts" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2666625..2669030 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium transporter component of a Na+/H+ antiporter" /protein_id="NP_391038.2" /db_xref="EnsemblGenomes-Gn:BSU31600" /db_xref="EnsemblGenomes-Tr:CAB15149" /db_xref="GOA:Q9K2S2" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR005663" /db_xref="InterPro:IPR018393" /db_xref="InterPro:IPR025383" /db_xref="SubtiList:BG12355" /db_xref="UniProtKB/Swiss-Prot:Q9K2S2" /translation="MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIY FLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYL SKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSR YGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILL GAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWI VSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTV AAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFS MAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLF KTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYP TLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNR LYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMA KIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLV IETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDS IASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGK SGE*" /label="mrpA CDS" gene 2666625..2669030 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /label="mrpA gene" CDS 2669023..2669454 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter complex" /protein_id="NP_391039.1" /db_xref="EnsemblGenomes-Gn:BSU31610" /db_xref="EnsemblGenomes-Tr:CAB15150" /db_xref="GOA:O05259" /db_xref="InterPro:IPR005281" /db_xref="InterPro:IPR007182" /db_xref="SubtiList:BG12356" /db_xref="UniProtKB/Swiss-Prot:O05259" /translation="MNEQKTNDLILQTATKLVSFIILLFSFYLFLSGHNAPGGGFVGG LITSSSIVLLLLAYDLKTVRSLLPVNFIYVAGAGLLLAVLTGVGSFVFGAPFLTHTFG YFQLPILGKTELATATIFDLGVYLVVVGITMTIIQTIGEEE*" /label="mrpB CDS" gene 2669023..2669454 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /label="mrpB gene" CDS 2669454..2669795 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of Na+/H+ antiporter" /protein_id="NP_391040.2" /db_xref="EnsemblGenomes-Gn:BSU31620" /db_xref="EnsemblGenomes-Tr:CAB15151" /db_xref="GOA:O05260" /db_xref="SubtiList:BG12357" /db_xref="UniProtKB/Swiss-Prot:O05260" /translation="MEILMAVLAGIIFMAATYLLLSKSLLRVIIGTALLSHGVHLMLL TMGGLKKGAAPILSEHAKSFVDPLPQALILTAIVISFGVTSFILVMAFRAYQELKSDD MDQMRGNDQHE*" /label="mrpC CDS" gene 2669454..2669795 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /label="mrpC gene" promotor_no_box 2669686..2669786 /Source="Nicolas_upshift_promotors" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2669746 /Source="Nicolas_upshifts" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2669788..2671269 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton transporter component of Na+/H+ antiporter" /protein_id="NP_391041.3" /db_xref="EnsemblGenomes-Gn:BSU31630" /db_xref="EnsemblGenomes-Tr:CAB15152" /db_xref="GOA:O05229" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR004775" /db_xref="SubtiList:BG12345" /db_xref="UniProtKB/Swiss-Prot:O05229" /translation="MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVIS GILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGE KRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESL KYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGM KGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMI WLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDM LIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGK FKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLY PAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE*" /label="mrpD CDS" gene 2669788..2671269 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /label="mrpD gene" S_feature complement(2670521..2672389) /Source="Nicolas_S_feature" /locus_tag="new_3250494_3252362_c" /HighExp="S2, Lbstat, T5.0H, T3.30H, S3, T4.0H, T3.0H, T2.30H, S1, T2.0H" /AntisenseName="mrpD" /AntisenseCor="-0.59706140653928796" /AntisenseRegPval="-26.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1212" CDS 2671275..2671751 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 15849754, 16233411, 16850406, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 15849754, 16233411, 16850406, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="YP_054591.2" /db_xref="EnsemblGenomes-Gn:BSU31640" /db_xref="EnsemblGenomes-Tr:CAE01465" /db_xref="GOA:Q7WY60" /db_xref="InterPro:IPR002758" /db_xref="SubtiList:BG14181" /db_xref="UniProtKB/Swiss-Prot:Q7WY60" /translation="MAFQILLNVFLAFCWMFLSNSPSAAGFITGYILGMLSLFFFRRF FTRQFYLWKLISIIKLCFIFIKELYLANVSVMKSVLSPKLNIRPGIFAFKTELTKDWE ITMLSLLITLTPGTLVMDISDDRTILYIHAMDIEDAEKAIFDIRESFEKAIQEVSR*" /label="mrpE CDS" gene 2671275..2671751 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /label="mrpE gene" CDS 2671751..2672035 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 11356194, 12682299, 15019740, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 11356194, 12682299, 15019740, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter for Na+ and cholate" /protein_id="NP_391043.2" /db_xref="EnsemblGenomes-Gn:BSU31650" /db_xref="EnsemblGenomes-Tr:CAB15153" /db_xref="GOA:O05228" /db_xref="InterPro:IPR007208" /db_xref="SubtiList:BG12344" /db_xref="UniProtKB/Swiss-Prot:O05228" /translation="MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINL IAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR*" /label="mrpF CDS" gene 2671751..2672035 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /label="mrpF gene" CDS 2672019..2672393 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 15019740, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 15019740, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="NP_391044.1" /db_xref="EnsemblGenomes-Gn:BSU31660" /db_xref="EnsemblGenomes-Tr:CAB15154" /db_xref="GOA:O05227" /db_xref="InterPro:IPR005133" /db_xref="SubtiList:BG12343" /db_xref="UniProtKB/Swiss-Prot:O05227" /translation="MIETAKVVVAVFILLGALICLIASFGVLRLPDVFTRAHAASKGS TLGVNMILLGVFFYLWFVTGELSAKILLGILFIFITSPIGGHLICRAAYNSGVKLDER SVQDDYNGIRNFVIKRKEDSYL*" /label="mrpG CDS" gene 2672019..2672393 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /label="mrpG gene" downshifts 2672364 /Source="Nicolas_upshifts" /id="D1637" /incds=0 /nref=86 /ntot=185 /MaxReadThrough="1.46493" /MaxDrop="6.023" /score="32.1865197" /energy="-12.7" /TU="NA" /idTUdmin="U2464" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2672432..2672812) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /EC_number="3.1.-.-" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25010423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proofreading thioesterase in bacillibactin biosynthesis" /protein_id="NP_391045.2" /db_xref="EnsemblGenomes-Gn:BSU31670" /db_xref="EnsemblGenomes-Tr:CAB15155" /db_xref="GOA:P14205" /db_xref="InterPro:IPR003736" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10382" /db_xref="UniProtKB/Swiss-Prot:P14205" /translation="MDMKHTLLEALGIEIVENTAERCVAVMPVDHRTVQPFGYLHGGA SVALAETAASAGAQNLIDHTTQACVGLEINANHLKSVKEGTVKAIAEPVHIGRTTIVY HIHIYDEQERLICISRCTLAVIKK*" /label="yuxO CDS" gene complement(2672432..2672812) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /label="yuxO gene" downshifts complement(2672434) /Source="Nicolas_upshifts" /id="D1638" /incds=0 /nref=41 /ntot=206 /MaxReadThrough="4.53972" /MaxDrop="3.98532" /score="-4.4938943" /energy="-12.7" /TU="U2469" /idTUdmin="U2469" /TUdmin="-1050" /isTUend="FALSE" /label="downshifts" CDS complement(2672831..2673475) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response quorum-sensing regulator" /protein_id="NP_391046.1" /db_xref="EnsemblGenomes-Gn:BSU31680" /db_xref="EnsemblGenomes-Tr:CAB15156" /db_xref="GOA:P14204" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2KRF" /db_xref="PDB:3ULQ" /db_xref="SubtiList:BG10381" /db_xref="UniProtKB/Swiss-Prot:P14204" /translation="MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQH DFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHG AISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL*" /label="comA CDS" gene complement(2672831..2673475) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /label="comA gene" S_feature complement(2673476..2673555) /Source="Nicolas_S_feature" /locus_tag="new_3253449_3253528_c" /HighExp="S2, Lbstat, M0t90, M40t90, MG 5, S1, ferm, T1.30H, nit, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1213" CDS complement(2673556..2675865) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /EC_number="2.7.-.-" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7698645, 7855425, 10419951, 14679219, 15066026, 16091050, 16787201, 20208433, 24130811; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_391047.2" /db_xref="EnsemblGenomes-Gn:BSU31690" /db_xref="EnsemblGenomes-Tr:CAB15157" /db_xref="GOA:Q99027" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10380" /db_xref="UniProtKB/Swiss-Prot:Q99027" /translation="MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQ FMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHL KDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIF NLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLIL TNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILG RMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFR LKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKV IFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINT PRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEK QRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVIS MTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLY RIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGI KERVRALDGRLRIETSEGKGFKADIEIEL*" /label="comP CDS" gene complement(2673556..2675865) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /label="comP gene" promotor_-35 2674550..2674557 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2674571..2674590 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2674586 /Source="Nicolas_upshifts" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 2675459..2676430 /Source="Nicolas_S_feature" /locus_tag="new_3255432_3256404" /HighExp="S8, C30, S7, Gly, Lbstat, Fru, C90, Pyr, G135, M/G" /AntisenseName="comX" /AntisenseCor="-2.6572990440080099E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.606" /TUlongSig="NA" /TUlongPSig="NA" /label="S1214" upshifts 2675459 /Source="Nicolas_upshifts" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2675471..2675487 /Source="Nicolas_upshift_promotors" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2675880..2676047) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484; Product type f: factor" /codon_start=1 /transl_table=11 /product="competence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified)" /protein_id="NP_391048.1" /db_xref="EnsemblGenomes-Gn:BSU31700" /db_xref="EnsemblGenomes-Tr:CAB15158" /db_xref="GOA:P45453" /db_xref="InterPro:IPR009233" /db_xref="SubtiList:BG11324" /db_xref="UniProtKB/Swiss-Prot:P45453" /translation="MQDLINYFLNYPEALKKLKNKEACLIGFDVQETETIIKAYNDYY LADPITRQWGD*" /label="comX CDS" gene complement(2675880..2676047) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /label="comX gene" CDS complement(2676035..2676933) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoprenyl transferase (pre-ComX modification)" /protein_id="NP_391049.2" /db_xref="EnsemblGenomes-Gn:BSU31710" /db_xref="EnsemblGenomes-Tr:CAB15159" /db_xref="GOA:P33690" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033965" /db_xref="SubtiList:BG10379" /db_xref="UniProtKB/Swiss-Prot:P33690" /translation="MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGE NLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSI YSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGV LLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDA SEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLD KEKKS**RNAY*VIQRGIQDARP" /label="comQ CDS" gene complement(2676035..2676933) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /label="comQ gene" S_feature complement(2676934..2677047) /Source="Nicolas_S_feature" /locus_tag="new_3256908_3257021_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, S4, T2.30H, M0t90, S5, M40t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1215" promotor_-10 complement(2677041..2677060) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2677047) /Source="Nicolas_upshifts" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2677074..2677080) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2677118..2677258) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="pleiotropic regulator" /protein_id="NP_391050.1" /db_xref="EnsemblGenomes-Gn:BSU31720" /db_xref="EnsemblGenomes-Tr:CAB15160" /db_xref="GOA:Q99039" /db_xref="InterPro:IPR012554" /db_xref="SubtiList:BG10378" /db_xref="UniProtKB/Swiss-Prot:Q99039" /translation="MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMK IS*" /label="degQ CDS" gene complement(2677118..2677258) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /label="degQ gene" downshifts complement(2677147) /Source="Nicolas_upshifts" /id="D1639" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="2.48672" /MaxDrop="4.10905" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2470" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2677259..2677345) /Source="Nicolas_S_feature" /locus_tag="new_3257233_3257319_c" /HighExp="S2, S4, BC, M9-stat, S5, S3, S6, BT, S8, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.843" /TUlongSig="NA" /TUlongPSig="NA" /label="S1216" promotor_-10 complement(2677329..2677348) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2677345) /Source="Nicolas_upshifts" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2677362..2677368) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2677445..2677463) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2677455) /Source="Nicolas_upshifts" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2677478..2677484) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2677480..2677605 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514001.1" /translation="MLKLRKILNLLDFNGFRIFTKQDYSPSYRIFKIEYAILGVS*" /label="hypothetical protein CDS" gene 2677480..2677605 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /label="gene" S_feature complement(2677633..2678062) /Source="Nicolas_S_feature" /locus_tag="new_3257607_3258036_c" /HighExp="LBGtran, G135, C90, Lbtran, Mt0, Lbexp, G150, G180, M40t45, C30" /AntisenseName="yuzC" /AntisenseCor="-0.77553193168722701" /AntisenseRegPval="-54.5" /CDS_PredictionProba="0.143959" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1217" promotor_-35 2677658..2677663 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2677675) /Source="Nicolas_upshifts" /id="D1640" /incds=0 /nref=23 /ntot=170 /MaxReadThrough="2.53578" /MaxDrop="3.52021" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2473" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 2677678..2677696 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2677680 /Source="Nicolas_upshifts" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="upshifts" CDS 2677719..2678087 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391051.2" /db_xref="EnsemblGenomes-Gn:BSU31730" /db_xref="EnsemblGenomes-Tr:CAB15161" /db_xref="InterPro:IPR016559" /db_xref="SubtiList:BG14052" /db_xref="UniProtKB/Swiss-Prot:O32089" /translation="MRYRYPWFYVYPYEVRRPPAPANNIDTFIRSAKQAAGIFADAQL VLSRIAGSRELSRRILTAAEQSDKQTIRRLIKQMGVRHEVDTVFNPDGIYISLIGTQS RMILALRWSEDRNHFASIRL*" /label="cotIC CDS" gene 2677719..2678087 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /label="cotIC gene" CDS complement(2678063..2679292) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /EC_number="3.1.4.52" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17153922, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17153922, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclic di-GMP phosphodiesterase" /protein_id="NP_391052.1" /db_xref="EnsemblGenomes-Gn:BSU31740" /db_xref="EnsemblGenomes-Tr:CAB15162" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR013976" /db_xref="InterPro:IPR014408" /db_xref="InterPro:IPR035919" /db_xref="SubtiList:BG10377" /db_xref="UniProtKB/Swiss-Prot:P14203" /translation="MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDL VINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISR CKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGC RGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELS KEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIY ILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLH REIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAY ECYLEALEWCHNLMDAK*" /label="pdeH CDS" gene complement(2678063..2679292) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /label="pdeH gene" S_feature 2678088..2679401 /Source="Nicolas_S_feature" /locus_tag="new_3258062_3259375" /HighExp="S4, S5, S3, S6, LoTm, S8, S7, T5.0H, B36, Pyr" /AntisenseName="yuxH" /AntisenseCor="-0.78363066752642896" /AntisenseRegPval="-56.4" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1218" promotor_-10 complement(2679327..2679346) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2679346) /Source="Nicolas_upshifts" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="upshifts" downshifts 2679359 /Source="Nicolas_upshifts" /id="D1641" /incds=0 /nref=6 /ntot=30 /MaxReadThrough="1.76106" /MaxDrop="4.58543" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2679361..2679368) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2679429..2680901) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /EC_number="6.3.4.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4296374, 12682299, 16199587, 24564896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate phosphoribosyltransferase" /protein_id="NP_391053.1" /db_xref="EnsemblGenomes-Gn:BSU31750" /db_xref="EnsemblGenomes-Tr:CAB15163" /db_xref="GOA:O32090" /db_xref="InterPro:IPR006405" /db_xref="InterPro:IPR007229" /db_xref="InterPro:IPR036068" /db_xref="SubtiList:BG13966" /db_xref="UniProtKB/Swiss-Prot:O32090" /translation="MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRR LPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFTGSLYS MKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKGVIGDEVALE FGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTA FKKYAETHKDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKA RKMLDEAGFTDAKVIASSDLDEHTIMNLKAQGARIDVWGVGTKLITAYDQPALGAVYK LVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQK RLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEE YKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE*" /label="pncB CDS" gene complement(2679429..2680901) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /label="pncB gene" downshifts complement(2679439) /Source="Nicolas_upshifts" /id="D1642" /incds=0 /nref=200 /ntot=267 /MaxReadThrough="4.08676" /MaxDrop="6.72747" /score="16.2382739" /energy="-14.5" /TU="NA" /idTUdmin="U2475" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" misc_feature 2680782..2680786 /Source="Nicolas_upshift_promotors" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2680789 /Source="Nicolas_upshifts" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2680899 /Source="Nicolas_upshifts" /id="D1643" /incds=0 /nref=1 /ntot=123 /MaxReadThrough="1.2059" /MaxDrop="3.08208" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS complement(2680917..2681468) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /EC_number="3.5.1.19" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15135535, 17382284, 18616465, 24340054, 24512664; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinamidase; NAD salvage pathway" /protein_id="NP_391054.1" /db_xref="EnsemblGenomes-Gn:BSU31760" /db_xref="EnsemblGenomes-Tr:CAB15164" /db_xref="GOA:O32091" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG13965" /db_xref="UniProtKB/Swiss-Prot:O32091" /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITN GDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYME KTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVAS FNQEGHAWALSHFANSIGAQVAE*" /label="pncA CDS" gene complement(2680917..2681468) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /label="pncA gene" promotor_-10 complement(2681490..2681509) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2681503) /Source="Nicolas_upshifts" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2681522..2681529) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2681565..2681963) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391055.1" /db_xref="EnsemblGenomes-Gn:BSU31770" /db_xref="EnsemblGenomes-Tr:CAB15165" /db_xref="InterPro:IPR012543" /db_xref="InterPro:IPR029064" /db_xref="PDB:2OHW" /db_xref="SubtiList:BG13964" /db_xref="UniProtKB/Swiss-Prot:O32092" /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQ VLRSKPYKEAEHELKNSHNVTLLINGELQYQSYSSYIQMASRYGVPFKIVSDLQFHTP LGIVIAADIAVNRELIYIQDDIYNRSVLKS*" /label="yueI CDS" gene complement(2681565..2681963) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /label="yueI gene" S_feature complement(2681964..2682034) /Source="Nicolas_S_feature" /locus_tag="new_3261938_3262008_c" /HighExp="Etha, dia5, Diami, dia15, H2O2, LBGtran, LPhT, G135, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1219" CDS complement(2682035..2682283) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391056.1" /db_xref="EnsemblGenomes-Gn:BSU31780" /db_xref="EnsemblGenomes-Tr:CAB15166" /db_xref="InterPro:IPR020260" /db_xref="SubtiList:BG13963" /db_xref="UniProtKB/Swiss-Prot:O32093" /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISY EEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM*" /label="yueH CDS" gene complement(2682035..2682283) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /label="yueH gene" promotor_-10 complement(2682306..2682325) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2682317) /Source="Nicolas_upshifts" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2682341..2682344) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2682356..2682577) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_391057.1" /db_xref="EnsemblGenomes-Gn:BSU31790" /db_xref="EnsemblGenomes-Tr:CAB15167" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13962" /db_xref="UniProtKB/Swiss-Prot:O32094" /translation="MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQL GDFVKINNQTSKTLFKDADITDETVSFNG*" /label="yueG CDS" gene complement(2682356..2682577) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /label="yueG gene" downshifts complement(2682383) /Source="Nicolas_upshifts" /id="D1644" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="3.65047" /MaxDrop="4.3681" /score="19.032155" /energy="-12.6" /TU="U2477,U2479,U2482" /idTUdmin="U2482" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2682571 /Source="Nicolas_upshifts" /id="D1645" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="1.17049" /MaxDrop="3.0193" /score="-7.47675224" /energy="-6.7" /TU="NA" /idTUdmin="U2480" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2682595..2682614) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2682601) /Source="Nicolas_upshifts" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2682627..2682636) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2682637..2683746) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391058.1" /db_xref="EnsemblGenomes-Gn:BSU31800" /db_xref="EnsemblGenomes-Tr:CAB15168" /db_xref="GOA:O32095" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13961" /db_xref="UniProtKB/Swiss-Prot:O32095" /translation="MLKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPM LIAGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITAQVTGLFN NLPDYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAV FGVVTNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAY FQGQLLICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFM DSPAKALFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMIL AVPVYAVVKAFFLNIVRLIKLRQRSRLEENAKPAE*" /label="yueF CDS" gene complement(2682637..2683746) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /label="yueF gene" promotor_-35 2683398..2683405 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2683420..2683439 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2683429..2683823 /Source="Nicolas_S_feature" /locus_tag="new_3263403_3263797" /HighExp="dia15, S8, H2O2, dia5, LBGstat, Paraq, C30, S7, Diami, G180" /AntisenseName="yueF" /AntisenseCor="0.28555063485711402" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1220" upshifts 2683429 /Source="Nicolas_upshifts" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2683794..2683813) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-10" upshifts complement(2683810) /Source="Nicolas_upshifts" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="upshifts" S_feature complement(2683812..2684252) /Source="Nicolas_S_feature" /locus_tag="new_3263786_3264226_c" /HighExp="Diami, S8, H2O2, S7, C90, Paraq, Salt, S1, dia15, dia5" /AntisenseName="yuzE" /AntisenseCor="0.47136608606324898" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1221" promotor_-35 2683815..2683817 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2683825 /Source="Nicolas_upshifts" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2683827..2683832) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-35" promotor_-10 2683833..2683852 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2683861..2684250 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391059.1" /db_xref="EnsemblGenomes-Gn:BSU31810" /db_xref="EnsemblGenomes-Tr:CAB15169" /db_xref="InterPro:IPR016789" /db_xref="InterPro:IPR019270" /db_xref="SubtiList:BG14054" /db_xref="UniProtKB/Swiss-Prot:O32096" /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQD GKIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYRVTFCFSD GDYQEFAGFDLDGTMYHSAFLQRLTEK*" /label="yuzE CDS" gene 2683861..2684250 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /label="yuzE gene" CDS complement(2684291..2684527) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391060.1" /db_xref="EnsemblGenomes-Gn:BSU31820" /db_xref="EnsemblGenomes-Tr:CAB15170" /db_xref="InterPro:IPR020139" /db_xref="SubtiList:BG14055" /db_xref="UniProtKB/Swiss-Prot:O32097" /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLID VKPDHITIEGARNSVCLIRIQHMISVTPDYSERV*" /label="yuzF CDS" gene complement(2684291..2684527) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /label="yuzF gene" downshifts complement(2684297) /Source="Nicolas_upshifts" /id="D1646" /incds=0 /nref=12 /ntot=37 /MaxReadThrough="5.19136" /MaxDrop="5.1675" /score="30.7642328" /energy="-9.9" /TU="U2482" /idTUdmin="U2481" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2684547..2684566) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2684561) /Source="Nicolas_upshifts" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2684563..2684703) /Source="Nicolas_S_feature" /locus_tag="new_3264537_3264677_c" /HighExp="BT, Diami, S8, Etha, Sw, C90, Salt, B36, LPhT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.998, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1222" promotor_-35 complement(2684580..2684589) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2684704..2685234) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /EC_number="3.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_391061.1" /db_xref="EnsemblGenomes-Gn:BSU31830" /db_xref="EnsemblGenomes-Tr:CAB15171" /db_xref="GOA:O32098" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="SubtiList:BG13960" /db_xref="UniProtKB/Swiss-Prot:O32098" /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADIN PDLAAKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAK EIALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEK LDQLIDQAQASVIKPV*" /label="yueE CDS" gene complement(2684704..2685234) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /label="yueE gene" promotor_-10 complement(2685254..2685273) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-10" upshifts complement(2685265) /Source="Nicolas_upshifts" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="upshifts" S_feature complement(2685267..2685353) /Source="Nicolas_S_feature" /locus_tag="new_3265241_3265327_c" /HighExp="BT, S8, S6, S7, B36, Etha, S5, S4, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1223" promotor_-35 complement(2685285..2685293) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-35" promotor_-10 complement(2685348..2685367) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2685355) /Source="Nicolas_upshifts" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2685381..2685390) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2685432..2686163) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /EC_number="1.1.1.320" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11745140, 21670841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="benzil reductase (benzoin forming)" /protein_id="NP_391062.1" /db_xref="EnsemblGenomes-Gn:BSU31840" /db_xref="EnsemblGenomes-Tr:CAB15172" /db_xref="GOA:O32099" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13959" /db_xref="UniProtKB/Swiss-Prot:O32099" /translation="MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLT QHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHY QLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRT FGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDF IAGTLLSLLEKGTENGRIYDIKEFL*" /label="bznD CDS" gene complement(2685432..2686163) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /label="bznD gene" downshifts complement(2685462) /Source="Nicolas_upshifts" /id="D1647" /incds=0 /nref=183 /ntot=253 /MaxReadThrough="2.76356" /MaxDrop="5.18507" /score="30.7642328" /energy="-9.9" /TU="NA" /idTUdmin="U2484" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2686178..2686197) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2686189) /Source="Nicolas_upshifts" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2686212..2686219) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2686226..2686681) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YueC protein" /protein_id="NP_391063.1" /db_xref="EnsemblGenomes-Gn:BSU31850" /db_xref="EnsemblGenomes-Tr:CAB15173" /db_xref="GOA:O32100" /db_xref="InterPro:IPR018920" /db_xref="InterPro:IPR020212" /db_xref="SubtiList:BG13958" /db_xref="UniProtKB/Swiss-Prot:O32100" /translation="MLSFSLFIPSAAAAQTEENTDVAPNQYEKKDIEIDTNYLHEDTY YEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIAAQSKQLGITFAEKPM TKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQENKKA*" /label="yueC CDS" gene complement(2686226..2686681) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /label="yueC gene" promotor_-35 2686634..2686640 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2686655..2686673 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2686663..2689030 /Source="Nicolas_S_feature" /locus_tag="new_3266637_3269004" /HighExp="Etha, Gly, Sw, Salt, LoTm, C30, BT, HiTm, Mal, G135" /AntisenseName="yueB" /AntisenseCor="-9.3455707286730305E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1224" upshifts 2686663 /Source="Nicolas_upshifts" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2686713..2689943) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022, 27179995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022, 27179995; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system; calcium-dependent phage SPP1 attachment site" /protein_id="NP_391064.1" /db_xref="EnsemblGenomes-Gn:BSU31860" /db_xref="EnsemblGenomes-Tr:CAB15174" /db_xref="GOA:O32101" /db_xref="InterPro:IPR023838" /db_xref="SubtiList:BG13957" /db_xref="UniProtKB/Swiss-Prot:O32101" /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQI AVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKY DAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKM SALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDEL KKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIR TGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGM KKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSD NKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDD SPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPE QDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKL EEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVN DAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKST LNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFID GMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTM ALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNV ASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIV LISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVF TILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYID IQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA*" /label="yueB CDS" gene complement(2686713..2689943) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /label="yueB gene" CDS complement(2689940..2694427) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system FtsK/SpoIIIE family ATPase" /protein_id="NP_391066.2" /db_xref="EnsemblGenomes-Gn:BSU31875" /db_xref="EnsemblGenomes-Tr:CAB15176" /db_xref="GOA:C0SPA7" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR022206" /db_xref="InterPro:IPR023839" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12375" /db_xref="UniProtKB/Swiss-Prot:C0SPA7" /translation="MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFN SGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFT GNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKIN ANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRT PRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVS LAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFH FPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDD LMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDL RFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLED DKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTL VRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAG TTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGS KNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAE LKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATD SKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDT GLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLF PSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADV YTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFR EKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFML TATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFA QMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLER KPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGL FDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRF SQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTE MKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESA R*" /label="yukAB CDS" gene complement(2689940..2694427) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /label="yukAB gene" promotor_-35 2693702..2693708 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2693723..2693741 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2693729..2694691 /Source="Nicolas_S_feature" /locus_tag="new_3273703_3274665" /HighExp="Etha, Sw, Gly, Salt, B60, M9-stat, LoTm, T0.30H, BT, LPhT" /AntisenseName="yukB" /AntisenseCor="-0.26212584196591598" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1225" upshifts 2693729 /Source="Nicolas_upshifts" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2694488..2695843) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /function="11.1: Protein and peptide secretion and trafficking" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukC protein" /protein_id="NP_391067.1" /db_xref="EnsemblGenomes-Gn:BSU31890" /db_xref="EnsemblGenomes-Tr:CAB15177" /db_xref="GOA:P71070" /db_xref="InterPro:IPR018778" /db_xref="SubtiList:BG12376" /db_xref="UniProtKB/Swiss-Prot:P71070" /translation="MSGEQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVI KDINPFFHKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNL SRLNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFA FEDYLKFNETLTFSAEAKAILDAESYDDLLELIQTHIDELEAKAKTYIHIPRKKWNIQ RYIGLGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYDAES LPESVQYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISI GRKLEYNDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSE TSLVDTSEEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKEKEDEKKETEKKDEKKDD K*" /label="yukC CDS" gene complement(2694488..2695843) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /label="yukC gene" downshifts complement(2694509) /Source="Nicolas_upshifts" /id="D1648" /incds=0 /nref=5 /ntot=116 /MaxReadThrough="6.33518" /MaxDrop="3.1562" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=5823 /isTUend="FALSE" /label="downshifts" CDS complement(2695858..2696097) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /function="11.1: Protein and peptide secretion and trafficking" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukD protein" /protein_id="NP_391068.1" /db_xref="EnsemblGenomes-Gn:BSU31900" /db_xref="EnsemblGenomes-Tr:CAB15178" /db_xref="InterPro:IPR014921" /db_xref="InterPro:IPR024962" /db_xref="InterPro:IPR029071" /db_xref="PDB:2BPS" /db_xref="SubtiList:BG12377" /db_xref="UniProtKB/Swiss-Prot:P71071" /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPP REGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL*" /label="yukD CDS" gene complement(2695858..2696097) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /label="yukD gene" CDS complement(2696167..2696460) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:11973144, 15576783, 22720735, 24798022, 24828531" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11973144, 15576783, 22720735, 24798022, 24828531; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small WGX100 secreted protein (ESX-dependent secretion)" /protein_id="NP_391069.2" /db_xref="EnsemblGenomes-Gn:BSU31910" /db_xref="EnsemblGenomes-Tr:CAB15179" /db_xref="GOA:C0SP85" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12378" /db_xref="UniProtKB/Swiss-Prot:C0SP85" /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMW EGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG*" /label="yukE CDS" gene complement(2696167..2696460) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /label="yukE gene" downshifts complement(2696177) /Source="Nicolas_upshifts" /id="D1649" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="6.21938" /MaxDrop="7.50121" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=4155 /isTUend="FALSE" /label="downshifts" downshifts 2696454 /Source="Nicolas_upshifts" /id="D1650" /incds=0 /nref=1 /ntot=26 /MaxReadThrough="2.85718" /MaxDrop="3.33739" /score="43.0917981" /energy="-17.1" /TU="NA" /idTUdmin="U2487" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" S_feature complement(2696461..2696539) /Source="Nicolas_S_feature" /locus_tag="new_3276435_3276513_c" /HighExp="T-1.10H, T1.0H, T-0.40H, T1.30H, BI, T2.30H, T3.0H, T-2.40H, T2.0H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1226" promotor_-35 2696502..2696509 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2696519..2696538) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2696520 /Source="Nicolas_upshifts" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2696524..2696541 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2696539) /Source="Nicolas_upshifts" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2696553..2696560) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2696598..2696603 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2696618..2696637 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2696630..2696736 /Source="Nicolas_S_feature" /locus_tag="new_3276604_3276710" /HighExp="S8, C30, S7, S6, Pyr, Glucon, B60, LoTm, C90, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="0.523, 0.76" /TUlongSig="NA" /TUlongPSig="NA" /label="S1227" upshifts 2696630 /Source="Nicolas_upshifts" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2696805..2696811 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2696825..2696844 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2696828 /Source="Nicolas_upshifts" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2696933..2696936 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-35" upshifts 2696945 /Source="Nicolas_upshifts" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="upshifts" promotor_-10 complement(2696948..2696967) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2696952..2696971 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-10" upshifts complement(2696970) /Source="Nicolas_upshifts" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2696981..2698249 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22797752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22797752; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AdeR-alanine)" /protein_id="NP_391070.2" /db_xref="EnsemblGenomes-Gn:BSU31920" /db_xref="EnsemblGenomes-Tr:CAB15180" /db_xref="GOA:P71073" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12379" /db_xref="UniProtKB/Swiss-Prot:P71073" /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPIT IEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVK QIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQI RKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIE QQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIE DVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEK RKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLK RISQIAEIDLKNVNQKFTIYLDIKLRHMDL*" /label="adeR CDS" gene 2696981..2698249 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /label="adeR gene" promotor_-35 complement(2696982..2696989) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2698309..2698328 /Source="Nicolas_upshift_promotors" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2698314 /Source="Nicolas_upshifts" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2698351..2699487 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /EC_number="1.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:488097, 8226620, 22720735, 22797752, 26202482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 488097, 8226620, 22720735, 22797752, 26202482; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-alanine dehydrogenase (NAD-dependent)" /protein_id="NP_391071.1" /db_xref="EnsemblGenomes-Gn:BSU31930" /db_xref="EnsemblGenomes-Tr:CAB15181" /db_xref="GOA:Q08352" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR007886" /db_xref="InterPro:IPR008141" /db_xref="InterPro:IPR008142" /db_xref="InterPro:IPR008143" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10468" /db_xref="UniProtKB/Swiss-Prot:Q08352" /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSG FENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPEL AQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAG VPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLIS NPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETV DHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALAD NTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA*" /label="ald CDS" gene 2698351..2699487 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /label="ald gene" downshifts 2699487 /Source="Nicolas_upshifts" /id="D1651" /incds=0 /nref=42 /ntot=190 /MaxReadThrough="5.86626" /MaxDrop="4.4689" /score="41.2794059" /energy="-14.2" /TU="U2493" /idTUdmin="U2493" /TUdmin="-769" /isTUend="FALSE" /label="downshifts" promotor_-35 2699536..2699544 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2699554 /Source="Nicolas_upshifts" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2699556..2699574 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2699599..2700276 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391073.2" /db_xref="EnsemblGenomes-Gn:BSU31945" /db_xref="EnsemblGenomes-Tr:CAB15183" /db_xref="InterPro:IPR019268" /db_xref="SubtiList:BG12380" /db_xref="UniProtKB/Swiss-Prot:C0SPB1" /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAIN VMSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREM KPLPHEITGPDNDLNDFIETYMKKAQDEKTPVYIFGSKFGPEQAADKIFGFTPTNGMH NIHMNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDC DHTQTSA*" /label="yukJ CDS" gene 2699599..2700276 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /label="yukJ gene" downshifts 2700260 /Source="Nicolas_upshifts" /id="D1652" /incds=0 /nref=37 /ntot=185 /MaxReadThrough="3.39608" /MaxDrop="5.40829" /score="9.49891506" /energy="-12" /TU="U2494" /idTUdmin="U2493" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2700320..2700529) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11112781, 20845982, 21890635, 24975514, 28880538; Product type r: regulator" /codon_start=1 /transl_table=11 /product="stimulator of DhbF tyrosine adenylation activity" /protein_id="YP_003097779.1" /db_xref="EnsemblGenomes-Gn:BSU31959" /db_xref="EnsemblGenomes-Tr:CAX52685" /db_xref="InterPro:IPR005153" /db_xref="UniProtKB/Swiss-Prot:C0H3Q6" /translation="MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGR EACLDYIQSHWSDMRPNSLKTVENV*" /label="mbtH CDS" gene complement(2700320..2700529) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /label="mbtH gene" downshifts complement(2700332) /Source="Nicolas_upshifts" /id="D1653" /incds=0 /nref=106 /ntot=174 /MaxReadThrough="1.39981" /MaxDrop="6.23998" /score="17.380299" /energy="-12" /TU="NA" /idTUdmin="U2496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2700545..2707681) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /EC_number="2.7.7.-" /EC_number="5.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11112781, 12354229, 16672620, 18957859, 26284661, 27731335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11112781, 12354229, 16672620, 18957859, 26284661, 27731335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase" /protein_id="NP_391076.3" /db_xref="EnsemblGenomes-Gn:BSU31960" /db_xref="EnsemblGenomes-Tr:CAB15186" /db_xref="GOA:P45745" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11243" /db_xref="UniProtKB/Swiss-Prot:P45745" /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPVN IALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALN WMKADLAKPVDLGYAPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYT ALIKGQTAKSRSFGSLQAILEEDTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPR TSNSFLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPM MGRIGSASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRR DLKLIGENHRLFGPQINLMPFDYGLDFAGVRGTTHNLSAGPVDDLSINVYDRTDGSGL RIDVDANPEVYSESDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNE TAKSEKLVSLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPADRISYMLEDAKPSCIITTEEIA ASLPDDLAVPELVLDQAVTQEIIKRYSPENQDVSVSLDHPAYIIYTSGSTGRPKGVVV TQKSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIR EPQALAQMIENFDINIMQATPTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQELQDL HCSVTNLYGPTETTIWSAAAFLEEGLKGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGE LYIAGTGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADH QIKIRGFRIELGEIDAVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRR YMGASLPDYMVPSAFVEMDELPLTPNGKLDRKALPAPDFSTSVSDRAPRTPQEEILCD LFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAA HLDLAQSACPALQRAERPEKIPLSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQG LLKAALYDLVCRHESLRTIFPESQGTSYQHILDADRACPELHVTEIAEKELSDRLAEA VRYSFDLAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHG RSPEWAPLAVQYADYALWQQELLGNEDDPNSLIAGQLAFWKETLKNLPDQLELPTDYS RPAEPSHDGDTIHFRIEPEFHKRLQELARANRVSLFMVLQSGLAALLTRLGAGTDIPI GSPIAGRNDDALGDLVGLFINTLVLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFE RLVEVLNPARSRATHPLFQIMLAFQNTPDAELHLPDMESSLRINSVGSAKFDLTLEIS EDRLADGTPNGMEGLLEYSTDLFKRETAQALADRLMRLLEAAESDPDEQIGNLDILAP EEHSSMVTDWQSVSEKIPHACLPEQFEKQAALRPDAIAVVYENQELSYAELNERANRL ARMMISEGVGPEQFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDA QPAFIMTNTKAANHIPPVENVPKIVLDDPELAEKLNTYPAGNPKNKDRTQPLSPLNTA YVIYTSGSTGVPKGVMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWG PLLHGGRLVIVPHHVSRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQAL SLRYVIFGGEALELSRLEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRA NSLIGCGIPDLGVYVLDERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPF GPPGTRMYRTGDVARLRADGSLDYVGRADHQVKIRGFRIELGEIEAALVQHPQLEDAA VIVREDQPGDKRLAAYVIPSEETFDTAELRRYAAERLPDYMVPAAFVTMKELPLTPNG KLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLA VQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMGSSQSALDVLLPLRTSGDKPPLF CVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPKTLDDMAADYIKQIRTVQ PKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPNHFLPIKEAPDDEEALI ALLALGGYDPDSLGEKPLDFEAAIEILRRDGSALASLDETVILNLKNTYVNSVGILGS YKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDIDCRHKDLCQPEPLAQ IGKVLAVKLEELNK*" /label="dhbF CDS" gene complement(2700545..2707681) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /label="dhbF gene" CDS complement(2707701..2708639) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /EC_number="3.3.2.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismatase (siderophore specific)" /protein_id="NP_391077.1" /db_xref="EnsemblGenomes-Gn:BSU31970" /db_xref="EnsemblGenomes-Tr:CAB15187" /db_xref="GOA:P45743" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11241" /db_xref="UniProtKB/Swiss-Prot:P45743" /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVD AFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSG PYEEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVT ACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQLQNAPADVQ KTSANTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRRE GAEVTFVELAERPTIEEWQKLLTTRSQQVLPNADYL*" /label="dhbB CDS" gene complement(2707701..2708639) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /label="dhbB gene" CDS complement(2708667..2710286) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /EC_number="2.7.7.58" /EC_number="6.3.2.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydroxybenzoate-AMP ligase" /protein_id="NP_391078.1" /db_xref="EnsemblGenomes-Gn:BSU31980" /db_xref="EnsemblGenomes-Tr:CAB15188" /db_xref="GOA:P40871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011963" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:1MD9" /db_xref="PDB:1MDB" /db_xref="PDB:1MDF" /db_xref="SubtiList:BG11020" /db_xref="UniProtKB/Swiss-Prot:P40871" /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAI TCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALP VFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEA EEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVC WLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTIT ALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAE GLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGY YKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLL AHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEF VESFPQTGVGKVSKKALREAISEKLLAGFKK*" /label="dhbE CDS" gene complement(2708667..2710286) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /label="dhbE gene" CDS complement(2710315..2711511) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /EC_number="5.4.4.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12354229, 16672620, 19777807, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismate synthase (siderophore-specific)" /protein_id="NP_391079.2" /db_xref="EnsemblGenomes-Gn:BSU31990" /db_xref="EnsemblGenomes-Tr:CAB15189" /db_xref="GOA:P45744" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="SubtiList:BG11242" /db_xref="UniProtKB/Swiss-Prot:P45744" /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPE ADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQ FDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAG SRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTE TMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTG MVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRA MGVDHI*" /label="dhbC CDS" gene complement(2710315..2711511) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /label="dhbC gene" promotor_-35 2711359..2711366 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2711381..2711400 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2711388 /Source="Nicolas_upshifts" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2711537..2712322) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /EC_number="1.3.1.28" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" /protein_id="NP_391080.2" /db_xref="EnsemblGenomes-Gn:BSU32000" /db_xref="EnsemblGenomes-Tr:CAB15190" /db_xref="GOA:P39071" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR003560" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11019" /db_xref="UniProtKB/Swiss-Prot:P39071" /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK LEKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIH SLSDEEWEATFSVNSTGVFNASRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASS KAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKT GIPLKKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV*" /label="dhbA CDS" gene complement(2711537..2712322) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /label="dhbA gene" S_feature complement(2712323..2712432) /Source="Nicolas_S_feature" /locus_tag="new_3292297_3292406_c" /HighExp="HiOs, GM 15, B60, nit, GM 10, GM 25, B36, GM 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1228" promotor_-10 complement(2712427..2712446) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2712432) /Source="Nicolas_upshifts" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2712434..2712515) /Source="Nicolas_S_feature" /locus_tag="new_3292408_3292489_c" /HighExp="HiOs, B60, nit, B36, GM 45, GM 10, BI, GM 15, GM 25, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1229" promotor_-35 complement(2712460..2712467) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2712516..2713385) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16889643, 19673474, 26284661, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillibactin trilactone hydrolase" /protein_id="NP_391081.2" /db_xref="EnsemblGenomes-Gn:BSU32010" /db_xref="EnsemblGenomes-Tr:CAB15191" /db_xref="GOA:O32102" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13974" /db_xref="UniProtKB/Swiss-Prot:O32102" /translation="MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPS TPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSA RHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIF GHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALR FALHPDGPHLSMG*" /label="besA CDS" gene complement(2712516..2713385) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /label="besA gene" S_feature complement(2713386..2713466) /Source="Nicolas_S_feature" /locus_tag="new_3293360_3293440_c" /HighExp="HiOs, B60, nit, GM 15, BI, B36, LoTm, T-5.40H, Lbexp, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1230" promotor_-10 complement(2713450..2713469) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2713466) /Source="Nicolas_upshifts" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2713483..2713490) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2713599..2714195) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /EC_number="1.7.3.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11598126, 16341843, 21190336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin containing enzyme subunit" /protein_id="NP_391082.1" /db_xref="EnsemblGenomes-Gn:BSU32020" /db_xref="EnsemblGenomes-Tr:CAB15192" /db_xref="GOA:O32103" /db_xref="InterPro:IPR000572" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13973" /db_xref="UniProtKB/Swiss-Prot:O32103" /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGDVPYYEDMTKWNL QVYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKE EAGYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLTPEHGFPLRGVFPHLYFWKS AKWLRGIQFTKENHPGFWERNGYHMRGDPWQNQRFTWD*" /label="yuiH CDS" gene complement(2713599..2714195) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /label="yuiH gene" S_feature complement(2714196..2714280) /Source="Nicolas_S_feature" /locus_tag="new_3294170_3294254_c" /HighExp="H2O2, Paraq, Cold, dia15, G135, B36, G180, B60, LoTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.204" /TUlongSig="NA" /TUlongPSig="NA" /label="S1231" promotor_-35 2714231..2714238 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2714248 /Source="Nicolas_upshifts" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2714253..2714272 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2714274..2714288) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2714280) /Source="Nicolas_upshifts" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2714296..2714300) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2714296..2714898 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717296, 15849754, 16850406, 24816803; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative biotin transporter" /protein_id="NP_391083.1" /db_xref="EnsemblGenomes-Gn:BSU32030" /db_xref="EnsemblGenomes-Tr:CAB15193" /db_xref="GOA:O32104" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13972" /db_xref="UniProtKB/Swiss-Prot:O32104" /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQ PFFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPA AFAAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGF MIWFMVKDTALAVILSFIAPAIYRSIHKATGFNRNHISST*" /label="bioYB CDS" gene 2714296..2714898 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /label="bioYB gene" downshifts 2714884 /Source="Nicolas_upshifts" /id="D1654" /incds=0 /nref=145 /ntot=206 /MaxReadThrough="3.24182" /MaxDrop="6.72885" /score="12.6395055" /energy="-6.3" /TU="U2498" /idTUdmin="U2498" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" CDS complement(2714968..2716296) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15135544, 15849754, 16850406, 23504016; Product type t : transporter" /codon_start=1 /transl_table=11 /product="histidine / basic amino acid transporter" /protein_id="NP_391084.1" /db_xref="EnsemblGenomes-Gn:BSU32040" /db_xref="EnsemblGenomes-Tr:CAB15194" /db_xref="GOA:O32105" /db_xref="InterPro:IPR018461" /db_xref="InterPro:IPR032813" /db_xref="SubtiList:BG13971" /db_xref="UniProtKB/Swiss-Prot:O32105" /translation="MNAVVIAVLLMLVLSLLRVNIVIALIIGALAGGLTGGLGLGETV KAFTDGLGGNATVAVSYAMLGAFAAALTKTGLPDAMVEASVKLIGNKEDSRKKALSKV LIVLIILIVSCFSQNVVPVHIAFIPVLIPPLLKIFNELEMDRRLIACVITFGLTAPYI LLPVGFGQIFQGMLKDNMADAGLNVPLADIPYALIIPVAGMVVGLILSVIVYRKPKQY ETKDISGAEASPYTRKSIGIAVLAIVVSLGVQLYLSQTLGVEGMIMGALAGLIVLFVS GVMKRDEADSLITDGMVLMAFIGFVMLVAAGFSNVLTKTGDVESLVKTSAGFIGHSQS LGALLMLIVGLLITMGIGSSFATIPVITTIFVPLCMQLGFSPMATIAIIGAAAALGDA GSPASDSTLGPTSGLSADGQHHHIWDTCVPTFIFYNIPLVIFGWIAALVL*" /label="hisP CDS" gene complement(2714968..2716296) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /label="hisP gene" downshifts complement(2714984) /Source="Nicolas_upshifts" /id="D1655" /incds=0 /nref=14 /ntot=114 /MaxReadThrough="4.26298" /MaxDrop="4.37949" /score="18.6861113" /energy="-15.4" /TU="U2500" /idTUdmin="U2500" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2716350..2716369) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2716353) /Source="Nicolas_upshifts" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2716384..2716391) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2716443..2717945) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /EC_number="3.4.11.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8057849, 9864319, 10449417, 26936797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytosol aminopeptidase" /protein_id="NP_391085.1" /db_xref="EnsemblGenomes-Gn:BSU32050" /db_xref="EnsemblGenomes-Tr:CAB15195" /db_xref="GOA:O32106" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="SubtiList:BG13970" /db_xref="UniProtKB/Swiss-Prot:O32106" /translation="MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLK EGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQ ETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDED TQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKS EMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKS GIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSG KTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQS FYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFA ESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE*" /label="pepA CDS" gene complement(2716443..2717945) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /label="pepA gene" downshifts complement(2716458) /Source="Nicolas_upshifts" /id="D1656" /incds=0 /nref=149 /ntot=220 /MaxReadThrough="4.44151" /MaxDrop="5.59726" /score="31.6277104" /energy="-16" /TU="NA" /idTUdmin="U2503" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2717510..2717524 /Source="Nicolas_upshift_promotors" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2717526 /Source="Nicolas_upshifts" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2717946..2718020) /Source="Nicolas_S_feature" /locus_tag="new_3297920_3297994_c" /HighExp="M40t90, Lbtran, LBGtran, Lbstat, C90, M0t90, T1.0H, LoTm, M40t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1232" promotor_-35 2717968..2717975 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2717986..2718005 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2717988..2718102 /Source="Nicolas_S_feature" /locus_tag="new_3297962_3298076" /HighExp="Etha, Cold, Gly, Sw, LoTm, BC, B60, C90, dia5, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1233" upshifts 2717988 /Source="Nicolas_upshifts" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2718015..2718034) /Source="Nicolas_upshift_promotors" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2718025) /Source="Nicolas_upshifts" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="upshifts" CDS 2718103..2718579 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391086.1" /db_xref="EnsemblGenomes-Gn:BSU32060" /db_xref="EnsemblGenomes-Tr:CAB15196" /db_xref="GOA:O32107" /db_xref="InterPro:IPR003832" /db_xref="SubtiList:BG13969" /db_xref="UniProtKB/Swiss-Prot:O32107" /translation="MELLTNFPLLSSLAAIIFAQVIKVPIQFIVSRKLDWSLVTSTGG MPSSHSAAVTALSTGVALEHGLDSSLFAVSAIFAVITMFDATGVRRHAGEQATVINKL VIDFNRFVNEAKDFPKAAEKEKQKKLKELLGHQPIEVFFGGLTGILLTLVLAYFFM*" /label="yuiD CDS" gene 2718103..2718579 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /label="yuiD gene" downshifts 2718528 /Source="Nicolas_upshifts" /id="D1657" /incds=0 /nref=18 /ntot=174 /MaxReadThrough="3.22946" /MaxDrop="3.90704" /score="10.9647804" /energy="-11.6" /TU="U2502" /idTUdmin="U2502" /TUdmin="-208" /isTUend="FALSE" /label="downshifts" CDS complement(2718610..2719266) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /experiment="publication(s) with functional evidences, PMID:26163297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26163297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stationary phase survival protein" /protein_id="NP_391087.1" /db_xref="EnsemblGenomes-Gn:BSU32070" /db_xref="EnsemblGenomes-Tr:CAB15197" /db_xref="GOA:O32108" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR036908" /db_xref="PDB:4WJT" /db_xref="PDB:4WLI" /db_xref="PDB:4WLK" /db_xref="SubtiList:BG13968" /db_xref="UniProtKB/Swiss-Prot:O32108" /translation="MMLNMIRRLLMTCLFLLAFGTTFLSVSGIEAKDLSKWVQEHQEK HLKHAGLRLKALQQKQTQTTSAAEDKTKPLEEAFDWDEYPVQRVTATGYTAGAESTGK NPGDPLYGLTYSGVKVKRDLYSTVAADPSVFPIGTILFIPNYGLGVVADTGSAIKGNR LDLYFETVKDVYNEWGKKTLDVYVIKKGTGKITEDELEKLNETKSLQVFRNQYKTVKE *" /label="spsC CDS" gene complement(2718610..2719266) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /label="spsC gene" downshifts complement(2718638) /Source="Nicolas_upshifts" /id="D1658" /incds=0 /nref=178 /ntot=253 /MaxReadThrough="0.714039999999999" /MaxDrop="6.31907" /score="33.0538307" /energy="-12.6" /TU="NA" /idTUdmin="U2505" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2718914..2718923 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2718937..2718956 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2718954 /Source="Nicolas_upshifts" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="upshifts" S_feature 2718956..2719402 /Source="Nicolas_S_feature" /locus_tag="new_3298930_3299376" /HighExp="S6, S8, S7, BT, B36, G/S, S5, Pyr, Cold, B60" /AntisenseName="yuiC" /AntisenseCor="0.52395204592174105" /AntisenseRegPval="-19.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1234" upshifts complement(2719280) /Source="Nicolas_upshifts" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2719282..2719293) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2719308..2719314) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2719359 /Source="Nicolas_upshifts" /id="D1659" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="7.61734" /MaxDrop="4.9382" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin="-323" /isTUend="FALSE" /label="downshifts" CDS complement(2719370..2719690) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391088.1" /db_xref="EnsemblGenomes-Gn:BSU32080" /db_xref="EnsemblGenomes-Tr:CAB15198" /db_xref="GOA:O32109" /db_xref="InterPro:IPR025917" /db_xref="SubtiList:BG13967" /db_xref="UniProtKB/Swiss-Prot:O32109" /translation="MISLPVVIISIVLFFVLFFGIGFLLNMLLRMSWIMAVIYPIVCL FIISKEKLISYVQSPGESFASLFHRVLSLAAADVLILVSGLAGAIVSGIAINMLRKRG YQMF*" /label="yuiB CDS" gene complement(2719370..2719690) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /label="yuiB gene" downshifts complement(2719384) /Source="Nicolas_upshifts" /id="D1660" /incds=0 /nref=151 /ntot=218 /MaxReadThrough="4.24535" /MaxDrop="5.6597" /score="13.4559443" /energy="-7.6" /TU="U2507,U2508" /idTUdmin="U2510" /TUdmin=660 /isTUend="FALSE" /label="downshifts" S_feature 2719404..2719614 /Source="Nicolas_S_feature" /locus_tag="new_3299378_3299588" /HighExp="S8, S6, S7, BT, Cold, Gly, H2O2, G/S, C30, G180" /AntisenseName="yuiB" /AntisenseCor="-0.11290507783715401" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1235" promotor_no_box 2719556..2719656 /Source="Nicolas_upshift_promotors" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2719616..2719725 /Source="Nicolas_S_feature" /locus_tag="new_3299590_3299699" /HighExp="S8, S6, BT, S7, Sw, Gly, G180, BC, Diami, H2O2" /AntisenseName="yuiB" /AntisenseCor="-7.7565560595235006E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.03, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1236" upshifts 2719616 /Source="Nicolas_upshifts" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="upshifts" downshifts 2719682 /Source="Nicolas_upshifts" /id="D1661" /incds=0 /nref=10 /ntot=28 /MaxReadThrough="3.79664" /MaxDrop="6.06021" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2719709..2719728) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2719714) /Source="Nicolas_upshifts" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" S_feature 2719727..2720278 /Source="Nicolas_S_feature" /locus_tag="new_3299701_3300252" /HighExp="S6, S8, S7, Cold, H2O2, BC, Sw, Pyr, BT, C30" /AntisenseName="yuiA" /AntisenseCor="5.87811391089679E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1237" promotor_-35 complement(2719743..2719750) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2719744..2719887) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391089.1" /db_xref="EnsemblGenomes-Gn:BSU32090" /db_xref="EnsemblGenomes-Tr:CAB15199" /db_xref="InterPro:IPR035272" /db_xref="InterPro:IPR036410" /db_xref="SubtiList:BG12389" /db_xref="UniProtKB/Swiss-Prot:O32110" /translation="MKTATTTASHACPFCSGKGYFQLILGGSETCPSCQGTGKDSHSF SSR*" /label="yuiA CDS" gene complement(2719744..2719887) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /label="yuiA gene" promotor_-10 complement(2719911..2719930) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2719932) /Source="Nicolas_upshifts" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2719946..2719949) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2720060..2721280) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 17015645, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-disulfide oxidoreductase" /protein_id="NP_391090.1" /db_xref="EnsemblGenomes-Gn:BSU32100" /db_xref="EnsemblGenomes-Tr:CAB15200" /db_xref="GOA:O05267" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12390" /db_xref="UniProtKB/Swiss-Prot:O05267" /translation="MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYH YETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQY DYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLT IVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYA VHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAG FENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNL GRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIG GLGLTLKKGKFKFF*" /label="yumB CDS" gene complement(2720060..2721280) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /label="yumB gene" downshifts complement(2720088) /Source="Nicolas_upshifts" /id="D1662" /incds=0 /nref=15 /ntot=123 /MaxReadThrough="3.19525" /MaxDrop="3.6794" /score="23.523765" /energy="-8.9" /TU="U2510" /idTUdmin="U2509" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2721281..2721408) /Source="Nicolas_S_feature" /locus_tag="new_3301255_3301382_c" /HighExp="Salt, S4, Etha, S5, S3, S7, S6, LoTm, B36, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.752, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1238" upshifts complement(2721408) /Source="Nicolas_upshifts" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2721410..2721474) /Source="Nicolas_S_feature" /locus_tag="new_3301384_3301448_c" /HighExp="Salt, Etha, Heat, BMM, BC, H2O2, Paraq, C30, Sw, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1239" promotor_-10 complement(2721410..2721428) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2721444..2721449) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2721465..2721484) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2721473) /Source="Nicolas_upshifts" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2721499..2721506) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2721548..2721555 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2721567..2721586 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2721567 /Source="Nicolas_upshifts" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="upshifts" CDS 2721612..2722610 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /EC_number="1.18.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15252706, 22938038, 26507228, 26965753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 22938038, 26507228, 26965753; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferredoxin-NADP+ reductase (flavodoxin)" /protein_id="NP_391091.2" /db_xref="EnsemblGenomes-Gn:BSU32110" /db_xref="EnsemblGenomes-Tr:CAB15201" /db_xref="GOA:O05268" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="PDB:3LZW" /db_xref="PDB:3LZX" /db_xref="SubtiList:BG12391" /db_xref="UniProtKB/Swiss-Prot:O05268" /translation="MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG QLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFK LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAIL GGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGE DKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETN IEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK*" /label="trxBB CDS" gene 2721612..2722610 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /label="trxBB gene" promotor_-10 complement(2721635..2721653) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2721650) /Source="Nicolas_upshifts" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2721670..2721675) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2722586 /Source="Nicolas_upshifts" /id="D1663" /incds=0 /nref=162 /ntot=262 /MaxReadThrough="0.70088" /MaxDrop="7.47867" /score="21.6819221" /energy="-12.8" /TU="U2511" /idTUdmin="U2511" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2722649..2722789) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein or unknown function" /protein_id="NP_391092.1" /db_xref="EnsemblGenomes-Gn:BSU32120" /db_xref="EnsemblGenomes-Tr:CAB15202" /db_xref="GOA:O32111" /db_xref="SubtiList:BG14056" /db_xref="UniProtKB/Swiss-Prot:O32111" /translation="MAQNEEKTPKSQKIQDRIIMAMIWVVAALVIALVVGTALNYINI FK*" /label="yuzG CDS" gene complement(2722649..2722789) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /label="yuzG gene" downshifts complement(2722661) /Source="Nicolas_upshifts" /id="D1664" /incds=0 /nref=61 /ntot=234 /MaxReadThrough="1.27572" /MaxDrop="5.65243" /score="32.0354025" /energy="-12.8" /TU="NA" /idTUdmin="U2515" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2722790..2722919) /Source="Nicolas_S_feature" /locus_tag="new_3302764_3302893_c" /HighExp="dia15, Salt, Cold, Diami, H2O2, Etha, GM 15, dia5, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.36371900000000001" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1240" promotor_-10 complement(2722900..2722919) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2722919) /Source="Nicolas_upshifts" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2722921..2723168) /Source="Nicolas_S_feature" /locus_tag="new_3302895_3303142_c" /HighExp="S8, S5, S6, S7, S4, ferm, nit, C30, Pyr, T5.0H" /AntisenseName="guaC" /AntisenseCor="-0.291283195124732" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1241" promotor_-35 complement(2722933..2722939) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2722976..2722983 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2722997..2723016 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2723005 /Source="Nicolas_upshifts" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2723068..2724048 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /EC_number="1.7.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 11591660, 6408059" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 11591660, 6408059; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP reductase (NADP-dependent)" /protein_id="NP_391093.2" /db_xref="EnsemblGenomes-Gn:BSU32130" /db_xref="EnsemblGenomes-Tr:CAB15203" /db_xref="GOA:O05269" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005994" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG12392" /db_xref="UniProtKB/Swiss-Prot:O05269" /translation="MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPAN MQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFV RQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAK SIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHV AHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY*" /label="guaC CDS" gene 2723068..2724048 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /label="guaC gene" upshifts complement(2723169) /Source="Nicolas_upshifts" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2723173..2723184) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2723198..2723204) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2724016 /Source="Nicolas_upshifts" /id="D1665" /incds=0 /nref=91 /ntot=186 /MaxReadThrough="1.24882" /MaxDrop="7.43286" /score="-2.82053244" /energy="-16.2" /TU="NA" /idTUdmin="U2514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2724121) /Source="Nicolas_upshifts" /id="D1666" /incds=0 /nref=24 /ntot=212 /MaxReadThrough="1.15696" /MaxDrop="6.12198" /score="23.834956" /energy="-16.2" /TU="NA" /idTUdmin="U2517" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2724122..2724745) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16210326, 21633969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates paiA expression)" /protein_id="NP_391094.2" /db_xref="EnsemblGenomes-Gn:BSU32140" /db_xref="EnsemblGenomes-Tr:CAB15204" /db_xref="GOA:P21341" /db_xref="InterPro:IPR007396" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG10696" /db_xref="UniProtKB/Swiss-Prot:P21341" /translation="MYIPKYFKVTNAEEIWNFVQENSFGTVVTTEQGKPIATHLPLGF NKKDDHYYITGHFAYGNPQWRTFEACEDVLVMFQGPHAYISSSWYSRENVPTWNYQAV HMYGKASMLEKDELAEELTIMLEKYEKHRDNPVLWDKLSPKLLESELKGIVGFKIKVE DIQAAYKLSQNRNETDYMNVIEQLQNEENPNAKQMAELMEDKLKKQI*" /label="paiB CDS" gene complement(2724122..2724745) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /label="paiB gene" CDS complement(2724769..2725287) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /EC_number="2.3.1.57" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16210326, 17588214, 21633970, 26818562, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16210326, 17588214, 21633970, 26818562, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyamine N-acetyltransferase" /protein_id="NP_391095.1" /db_xref="EnsemblGenomes-Gn:BSU32150" /db_xref="EnsemblGenomes-Tr:CAB15205" /db_xref="GOA:P21340" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1TIQ" /db_xref="SubtiList:BG10695" /db_xref="UniProtKB/Swiss-Prot:P21340" /translation="MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESA FNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSF QKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDE EQTDLIMAKTLI*" /label="paiA CDS" gene complement(2724769..2725287) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /label="paiA gene" misc_feature complement(2725334..2725353) /Source="Nicolas_upshift_promotors" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2725346) /Source="Nicolas_upshifts" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2725348..2725456) /Source="Nicolas_S_feature" /locus_tag="new_3305322_3305430_c" /HighExp="LoTm, HiTm, G135, Salt, G180, Cold, LBGstat, T0.0H, B36, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1242" promotor_-10 complement(2725443..2725460) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2725454) /Source="Nicolas_upshifts" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2725475..2725482) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2725610) /Source="Nicolas_upshifts" /id="D1667" /incds=0 /nref=267 /ntot=269 /MaxReadThrough="1.56881" /MaxDrop="8.24828" /score="12.6937405" /energy="-18.7" /TU="NA" /idTUdmin="U2518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2725625..2725987) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17698959, 19478995, 20097860, 25447545; Product type c: carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier chaperone involved in Fe-S cluster assembly" /protein_id="NP_391096.1" /db_xref="EnsemblGenomes-Gn:BSU32160" /db_xref="EnsemblGenomes-Tr:CAB15206" /db_xref="GOA:O32113" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR016092" /db_xref="InterPro:IPR017870" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG14049" /db_xref="UniProtKB/Swiss-Prot:O32113" /translation="MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYG MGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASC GCGSSFRTATNAGKPEEC*" /label="sufA CDS" gene complement(2725625..2725987) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /label="sufA gene" promotor_-10 complement(2726018..2726037) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2726028) /Source="Nicolas_upshifts" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2726051..2726058) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2726066..2726920) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /EC_number="5.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 14627808, 16723397, 19307721, 28873470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diaminopimelate epimerase" /protein_id="NP_391097.1" /db_xref="EnsemblGenomes-Gn:BSU32170" /db_xref="EnsemblGenomes-Tr:CAB15207" /db_xref="GOA:O32114" /db_xref="InterPro:IPR001653" /db_xref="InterPro:IPR018510" /db_xref="SubtiList:BG14048" /db_xref="UniProtKB/Swiss-Prot:O32114" /translation="MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTG IGSDGMILICPSDQAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIET LSGLVKAEVQVENGKVNVVTVDMGEPRLTKSELPMLDGGEEHTINETMAFGEVELTGT AVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVETVNEQELHFRVWER GSGITQACGTGACAAAVASVLNGVSKRNQDITVHLAGGDLVINWKDNGHVMMTGPAET VCEGVYFL*" /label="dapF CDS" gene complement(2726066..2726920) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /label="dapF gene" promotor_-10 complement(2726636..2726655) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2726644) /Source="Nicolas_upshifts" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2726668..2726677) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2726942..2726961) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2726956) /Source="Nicolas_upshifts" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2726976..2726979) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2727043..2728257) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+(H+)/nucleoside cotransporter" /protein_id="NP_391098.1" /db_xref="EnsemblGenomes-Gn:BSU32180" /db_xref="EnsemblGenomes-Tr:CAB15208" /db_xref="GOA:O32115" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG14047" /db_xref="UniProtKB/Swiss-Prot:O32115" /translation="MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGY IVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFS ALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAG LTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETE KTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGG AFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGS HIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLA NLLSAAIAGMFI*" /label="yutK CDS" gene complement(2727043..2728257) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /label="yutK gene" promotor_-35 2727592..2727598 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2727613..2727631 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2727620 /Source="Nicolas_upshifts" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="upshifts" S_feature 2727624..2728393 /Source="Nicolas_S_feature" /locus_tag="new_3307598_3308367" /HighExp="Etha, Salt, Gly, M9-stat, Sw, LoTm, B60, BC, Heat, S0" /AntisenseName="yutK" /AntisenseCor="-0.36240965013078302" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1243" promotor_-10 complement(2728294..2728313) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-10" upshifts complement(2728299) /Source="Nicolas_upshifts" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="upshifts" promotor_-35 complement(2728328..2728335) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-35" downshifts 2728350 /Source="Nicolas_upshifts" /id="D1668" /incds=0 /nref=3 /ntot=58 /MaxReadThrough="4.13852" /MaxDrop="3.94079" /score="20.5760616" /energy="-10.5" /TU="U2521" /idTUdmin="U2521" /TUdmin="-1913" /isTUend="FALSE" /label="downshifts" CDS complement(2728394..2728630) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391099.1" /db_xref="EnsemblGenomes-Gn:BSU32190" /db_xref="EnsemblGenomes-Tr:CAB15209" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR022916" /db_xref="SubtiList:BG14051" /db_xref="UniProtKB/Swiss-Prot:O32116" /translation="MNPMIEFCVSNLAHGSQEARAILEKDPNLDVLEYGCLSYCGTCM ESLFALVNGEVVMGETPAELVENIYTFIEENPMF*" /label="yuzB CDS" gene complement(2728394..2728630) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /label="yuzB gene" S_feature 2728395..2728811 /Source="Nicolas_S_feature" /locus_tag="new_3308369_3308785" /HighExp="Salt, LoTm, Gly, Etha, Sw, Heat, S0, C30, M9-stat, Mal" /AntisenseName="yuzB" /AntisenseCor="-5.6824456709843603E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1244" downshifts complement(2728412) /Source="Nicolas_upshifts" /id="D1669" /incds=0 /nref=175 /ntot=239 /MaxReadThrough="1.28789" /MaxDrop="7.32368" /score="41.4640292" /energy="-10.5" /TU="NA" /idTUdmin="U2523" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2728595..2728596) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2728600..2728604) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2728602) /Source="Nicolas_upshifts" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2728645..2728664) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2728646) /Source="Nicolas_upshifts" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2728678..2728685) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2728788..2728793 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2728807..2728826 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2728813 /Source="Nicolas_upshifts" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="upshifts" CDS 2728893..2729960 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /EC_number="1.6.-.-" /function="16.10: Respire" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17015645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase" /protein_id="NP_391100.2" /db_xref="EnsemblGenomes-Gn:BSU32200" /db_xref="EnsemblGenomes-Tr:CAB15210" /db_xref="GOA:O32117" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14046" /db_xref="UniProtKB/Swiss-Prot:O32117" /translation="MKKLVLIGGGYGNMRVLHRLLPNQLPDDVSITLIDRNPYHCLKT EYYALAAGTISDHHIRVSFPEHPRLDVQYGDITSIDIVQKQVLFQDREPISYDDAIIG LGCEDKYHNVPGAPEFTYSIQTIDQSRETYQKLNNLSANATVAIVGAGLSGVELASEL RESRDDLNIILFDRGNLILSSFPERLSKYVQKWFEEHGVRIINRANITKVEEGVVYNH DDPISADAIVWTAGIQPNKVVRDLDVEKDAQGRIVLTPHHNLPGDEHLYVVGDCASLP HAPSAQLAEAQAEQIVQILQKRWNGEALPESMPQFKLKGVLGSLGKKAGFGLVADRPL IGRVPRMLKSGLLWMYKHHNG*" /label="yutJ CDS" gene 2728893..2729960 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /label="yutJ gene" downshifts 2729944 /Source="Nicolas_upshifts" /id="D1670" /incds=0 /nref=4 /ntot=110 /MaxReadThrough="3.51945" /MaxDrop="3.02708" /score="6.15657679" /energy="-10.8" /TU="U2521,U2525" /idTUdmin="U2521" /TUdmin="-319" /isTUend="FALSE" /label="downshifts" CDS complement(2729986..2730312) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11551182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reduction management enzyme" /protein_id="NP_391101.1" /db_xref="EnsemblGenomes-Gn:BSU32210" /db_xref="EnsemblGenomes-Tr:CAB15211" /db_xref="InterPro:IPR009190" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14053" /db_xref="UniProtKB/Swiss-Prot:O32118" /translation="MMKPVMLSVYGAENVCASCVNMPTAKDTYEWLEAALKRKYPNQP FEMQYIDIHEPPDNEHAKELAEKIRNDEYFYPLVLVEDKIVGEGNPKLKDVYEEMEKH GYTENR*" /label="yuzD CDS" gene complement(2729986..2730312) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /label="yuzD gene" downshifts complement(2730009) /Source="Nicolas_upshifts" /id="D1671" /incds=0 /nref=4 /ntot=180 /MaxReadThrough="1.63835" /MaxDrop="3.17377" /score="-8.05690984" /energy="-10.8" /TU="NA" /idTUdmin="U2526" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2730344..2730363) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2730361) /Source="Nicolas_upshifts" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2730376..2730383) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2730396..2730400 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2730412..2730747 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17237162, 21749987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative iron-sulfur scaffold protein" /protein_id="NP_391102.1" /db_xref="EnsemblGenomes-Gn:BSU32220" /db_xref="EnsemblGenomes-Tr:CAB15212" /db_xref="GOA:O32119" /db_xref="InterPro:IPR001075" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG14045" /db_xref="UniProtKB/Swiss-Prot:O32119" /translation="MCYNRESNFANQTIDFYCYTEYNGFMTTKGANVMTEVEMKEQVQ EVLDKLRPFLLRDGGDCELVDVDEGIVKLRLLGACGSCPSSTITLKAGIERALLEEVP GVVEVEQVF*" /label="yutI CDS" gene 2730412..2730747 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /label="yutI gene" promotor_-10 2730413..2730432 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2730418 /Source="Nicolas_upshifts" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2730537) /Source="Nicolas_upshifts" /id="D1672" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="1.28655" /MaxDrop="3.45909" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2730725 /Source="Nicolas_upshifts" /id="D1673" /incds=0 /nref=258 /ntot=281 /MaxReadThrough="3.6035" /MaxDrop="7.98922" /score="39.7008566" /energy="-19.5" /TU="U2527" /idTUdmin="U2527" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(2730789..2732762) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8576092, 11406580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acylaminoacyl-peptidase" /protein_id="NP_391103.2" /db_xref="EnsemblGenomes-Gn:BSU32230" /db_xref="EnsemblGenomes-Tr:CAB15213" /db_xref="GOA:P39839" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10463" /db_xref="UniProtKB/Swiss-Prot:P39839" /translation="MKKLITADDITAIVSVTDPQYAPDGTRAAYVKSQVNQEKDSYTS NIWIYETKTGGSVPWTHGEKRSTDPRWSPDGRTLAFISDREGDAAQLYIMSTEGGEAR KLTDIPYGVSKPLWSPDGESILVTVSLGEGESIDDREKTEQDSYEPVEVQGLSYKRDG KGLTRGAYAQLVLVSVKSGEMKELTSHKADHGDPAFSPDGKWLVFSANLTETDDASKP HDVYIMSLESGDLKQVTPHRGSFGSSSFSPDGRYLALLGNEKEYKNATLSKAWLYDIE QGRLTCLTEMLDVHLADALIGDSLIGGAEQRPIWTKDSQGFYVIGTDQGSTGIYYISI EGLVYPIRLEKEYINSFSLSPDEQHFIASVTKPDRPSELYSIPLGQEEKQLTGANDKF VREHTISIPEEIQYATEDGVMVNGWLMRPAQMEGETTYPLILNIHGGPHMMYGHTYFH EFQVLAAKGYAVVYINPRGSHGYGQEFVNAVRGDYGGKDYDDVMQAVDEAIKRDPHID PKRLGVTGGSYGGFMTNWIVGQTNRFKAAVTQRSISNWISFHGVSDIGYFFTDWQLEH DMFEDTEKLWDRSPLKYAANVETPLLILHGERDDRCPIEQAEQLFIALKKMGKETKLV RFPNASHNLSRTGHPRQRIKRLNYISSWFDQHL*" /label="yuxL CDS" gene complement(2730789..2732762) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /label="yuxL gene" downshifts complement(2730801) /Source="Nicolas_upshifts" /id="D1674" /incds=0 /nref=19 /ntot=114 /MaxReadThrough="1.79797" /MaxDrop="3.85507" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2732777..2732795) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2732800) /Source="Nicolas_upshifts" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2732807..2732815) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2732870..2733799) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /EC_number="2.7.1.39" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine kinase" /protein_id="NP_391104.1" /db_xref="EnsemblGenomes-Gn:BSU32240" /db_xref="EnsemblGenomes-Tr:CAB15214" /db_xref="GOA:P04948" /db_xref="InterPro:IPR000870" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10462" /db_xref="UniProtKB/Swiss-Prot:P04948" /translation="MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKW SFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAA IVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRV PNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGK IMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQ LALHFPHCEVDALTVPKEGSIIERNPLYQVKSV*" /label="thrB CDS" gene complement(2732870..2733799) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /label="thrB gene" downshifts complement(2732883) /Source="Nicolas_upshifts" /id="D1675" /incds=0 /nref=222 /ntot=261 /MaxReadThrough="2.39521" /MaxDrop="7.03759" /score="15.5945196" /energy="-10.3" /TU="NA" /idTUdmin="U2530" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2733796..2734854) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /EC_number="4.2.3.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 3139660, 8768250" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 3139660, 8768250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="NP_391105.1" /db_xref="EnsemblGenomes-Gn:BSU32250" /db_xref="EnsemblGenomes-Tr:CAB15215" /db_xref="GOA:P04990" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /db_xref="InterPro:IPR026260" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10461" /db_xref="UniProtKB/Swiss-Prot:P04990" /translation="MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIE LHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCI VIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIE GQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEG AAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIA RVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPNTAVDISEIKPVT LPTDEDSILEYVKGAARV*" /label="thrC CDS" gene complement(2733796..2734854) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /label="thrC gene" CDS complement(2734854..2736155) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /EC_number="1.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3139660, 27299409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3139660, 27299409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine dehydrogenase" /protein_id="NP_391106.1" /db_xref="EnsemblGenomes-Gn:BSU32260" /db_xref="EnsemblGenomes-Tr:CAB15216" /db_xref="GOA:P19582" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /db_xref="InterPro:IPR016204" /db_xref="InterPro:IPR019811" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10460" /db_xref="UniProtKB/Swiss-Prot:P19582" /translation="MKAIRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLV KDLEKKREVDLPKEVLTTEVYDVIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVT ANKDLMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNG TTNFILTKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNV DLEDVKVKGISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSA VHNEFNAVYVYGEAVGETMFYGPGAGSMPTATSVVSDLVAVMKNMRLGVTGNSFVGPQ YEKNMKSPSDIYAQQFLRIHVKDEVGSFSKITSVFSERGVSFEKILQLPIKGHDELAE IVIVTHHTSEADFSDILQNLNDLEVVQEVKSTYRVEGNGWS*" /label="hom CDS" gene complement(2734854..2736155) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /label="hom gene" promotor_-35 2736040..2736049 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2736064..2736083 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2736071 /Source="Nicolas_upshifts" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2736156..2736237) /Source="Nicolas_S_feature" /locus_tag="new_3316130_3316211_c" /HighExp="T3.0H, T2.30H, T3.30H, S2, C90, T4.0H, BMM, SMM, MG 120, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1245" promotor_-10 complement(2736222..2736241) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2736237) /Source="Nicolas_upshifts" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2736239..2736355) /Source="Nicolas_S_feature" /locus_tag="new_3316213_3316329_c" /HighExp="S5, S3, S4, S7, S6, S8, BT, B36, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1246" promotor_-35 complement(2736256..2736263) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2736356..2737375) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /function="16.3: Control" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15231775, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat-associated protein" /protein_id="NP_391107.1" /db_xref="EnsemblGenomes-Gn:BSU32270" /db_xref="EnsemblGenomes-Tr:CAB15217" /db_xref="GOA:O32123" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014254" /db_xref="SubtiList:BG14044" /db_xref="UniProtKB/Swiss-Prot:O32123" /translation="MVKGTIKEKYGIHIRQLSMYQHTYQCFQTPNSYFLIVPVSQFSE TELAELYYMSQYLQEQSDPYVSVFIFTKEGELTFEHEGKTYALLKAAPPYSNRAFSIG AELAEFHRKGRGYPYEVKAAGRIGQWKDLWGKRIDQLEAFWQRKVQTPPHEPFDKKMI ESFPYYLGLSENAIQYLVDTELDDKPQAADSGTICHQRMERHTWSPESLIRIPADWVF DHASRDLAEYMRHTFLHHRQDFNQQGFLFLQEYEQVTPLSSFSKRLLYSRLLFPLHYF EIVESYYMSSESEKHYFEEQLDFILNDCGRYEQFLNTAQEFMNMRAQKLFVPRVSWLG KGSSR*" /label="cotNH CDS" gene complement(2736356..2737375) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /label="cotNH gene" promotor_-35 2737183..2737188 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2737204..2737222 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2737208 /Source="Nicolas_upshifts" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2737398..2737416) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2737405) /Source="Nicolas_upshifts" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2737414..2737419 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2737432..2737437) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2737435..2737499 /Source="Nicolas_S_feature" /locus_tag="new_3317409_3317473" /HighExp="S4, S5, S3, S6, S7, B36, S8, LoTm, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1247" promotor_-10 2737435..2737453 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2737435 /Source="Nicolas_upshifts" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2737472..2737481 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2737494..2737513 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2737501 /Source="Nicolas_upshifts" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="upshifts" CDS 2737528..2738028 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_391108.1" /db_xref="EnsemblGenomes-Gn:BSU32280" /db_xref="EnsemblGenomes-Tr:CAB15218" /db_xref="GOA:O32124" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="SubtiList:BG14043" /db_xref="UniProtKB/Swiss-Prot:O32124" /translation="MSENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLT IDECTLNVNRVLAKREVQNAILTGIELDVLAEQKKLSEPLQTMLEIDESLYGVDEVLA FSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISAAASSRLAH RARHTE*" /label="yutG CDS" gene 2737528..2738028 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /label="yutG gene" CDS complement(2738055..2738825) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /EC_number="3.1.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15664928, 16766528, 27907199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15664928, 16766528, 27907199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5' nucleotidase, promiscuous" /protein_id="NP_391109.1" /db_xref="EnsemblGenomes-Gn:BSU32290" /db_xref="EnsemblGenomes-Tr:CAB15219" /db_xref="GOA:O32125" /db_xref="InterPro:IPR006354" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3PDW" /db_xref="SubtiList:BG14042" /db_xref="UniProtKB/Swiss-Prot:O32125" /translation="MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTN NSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIE ENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPG NGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINA GMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI*" /label="nucF CDS" gene complement(2738055..2738825) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /label="nucF gene" downshifts complement(2738083) /Source="Nicolas_upshifts" /id="D1676" /incds=0 /nref=137 /ntot=243 /MaxReadThrough="2.15034" /MaxDrop="4.82801" /score="8.09889752" /energy="-15.6" /TU="NA" /idTUdmin="U2535" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2738854..2739288) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391110.1" /db_xref="EnsemblGenomes-Gn:BSU32300" /db_xref="EnsemblGenomes-Tr:CAB15220" /db_xref="InterPro:IPR008201" /db_xref="PDB:1YLM" /db_xref="SubtiList:BG14041" /db_xref="UniProtKB/Swiss-Prot:O32126" /translation="MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHL LIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQ YLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK*" /label="yutE CDS" gene complement(2738854..2739288) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /label="yutE gene" CDS complement(2739312..2739587) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12770717, 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391111.2" /db_xref="EnsemblGenomes-Gn:BSU32310" /db_xref="EnsemblGenomes-Tr:CAB15221" /db_xref="InterPro:IPR009370" /db_xref="PDB:2KL5" /db_xref="SubtiList:BG14040" /db_xref="UniProtKB/Swiss-Prot:O32127" /translation="MILIQNAEFELVHNFKDGFNEEAFKARYSDILNKYDYIVGDWGY GQLRLKGFFDDQNQKATFETKISTLDEYIYEYCNFGCAYFVLKRIRK*" /label="yutD CDS" gene complement(2739312..2739587) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /label="yutD gene" promotor_-10 complement(2739607..2739626) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2739632) /Source="Nicolas_upshifts" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2739634..2740326) /Source="Nicolas_S_feature" /locus_tag="new_3319608_3320300_c" /HighExp="G135, G150, G180, H2O2, LBGtran, LBGexp, Paraq, dia15, C90, HiOs" /AntisenseName="yutC" /AntisenseCor="-0.57886192731570996" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1248" promotor_-35 complement(2739640..2739647) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2739650..2739656 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2739671..2739682 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2739679 /Source="Nicolas_upshifts" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="upshifts" CDS 2739702..2740334 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative sporulation-related lipoprotein" /protein_id="NP_391112.1" /db_xref="EnsemblGenomes-Gn:BSU32320" /db_xref="EnsemblGenomes-Tr:CAB15222" /db_xref="GOA:O32128" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG14039" /db_xref="UniProtKB/Swiss-Prot:O32128" /translation="MKRTAVSLCLLTGLLSGCGGAGLDNAQNVRNQTQNQTKPIHVSD RNEAFNRHNENEQFGYVRYQKEQFDGEQQKTPVMNREETAHMISSLTVQLPHIQDAAT LVTDREALVVYKTDSKNRELTADQVKKTAASVIPRYYHVYISDNPNHMQSVENYSNLG SGSRDIREIMSGTIQEMKTSPQGSPVSENENANGETRQDMKIDRNDKNAR*" /label="yutC CDS" gene 2739702..2740334 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /label="yutC gene" downshifts 2740295 /Source="Nicolas_upshifts" /id="D1677" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="1.84979" /MaxDrop="3.55825" /score="-2.38634221" /energy="-9.6" /TU="NA" /idTUdmin="U2536" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2740350..2741246) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /EC_number="2.8.1.8" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15362861, 16835858, 19028902, 19820084, 25341020; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoyl synthase (lipoic acid synthetase)" /protein_id="NP_391113.2" /db_xref="EnsemblGenomes-Gn:BSU32330" /db_xref="EnsemblGenomes-Tr:CAB15223" /db_xref="GOA:O32129" /db_xref="InterPro:IPR003698" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031691" /db_xref="SubtiList:BG14038" /db_xref="UniProtKB/Swiss-Prot:O32129" /translation="MAKKDEHLRKPEWLKIKLNTNENYTGLKKLMRENNLHTVCEEAK CPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDLQEPERVADSVALMNLK HAVITAVARDDQKDGGAGIFAETVRAIRRKSPFTTIEVLPSDMGGNYDNLKTLMDTRP DILNHNIETVRRLTPRVRARATYDRSLEFLRRAKEMQPDIPTKSSIMIGLGETKEEII EVMDDLLANNVDIMAIGQYLQPTKKHLKVQKYYHPDEFAELKEIAMQKGFSHCEAGPL VRSSYHADEQVNEASKKRQAQA*" /label="lipA CDS" gene complement(2740350..2741246) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /label="lipA gene" downshifts complement(2740371) /Source="Nicolas_upshifts" /id="D1678" /incds=0 /nref=186 /ntot=261 /MaxReadThrough="3.83236" /MaxDrop="5.33309" /score="14.803008" /energy="-9.6" /TU="U2537" /idTUdmin="U2537" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(2741247..2741381) /Source="Nicolas_S_feature" /locus_tag="new_3321221_3321355_c" /HighExp="HiOs, LBGtran, dia15, dia5, C90, Diami, dia0, LBGexp, Heat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1249" promotor_-10 complement(2741368..2741387) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-10" upshifts complement(2741381) /Source="Nicolas_upshifts" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="upshifts" promotor_-35 complement(2741403..2741407) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-35" promotor_-35 2741421..2741427 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2741441..2741452 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2741453 /Source="Nicolas_upshifts" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="upshifts" CDS 2741481..2742461 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /EC_number="3.4.-.-" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12813075; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific L-Ala-D-Glu endopeptidase" /protein_id="NP_391114.2" /db_xref="EnsemblGenomes-Gn:BSU32340" /db_xref="EnsemblGenomes-Tr:CAB15224" /db_xref="GOA:O32130" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG13975" /db_xref="UniProtKB/Swiss-Prot:O32130" /translation="MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQ IPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVF DGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISE FMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVK STCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVG SSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK*" /label="lytH CDS" gene 2741481..2742461 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /label="lytH gene" upshifts complement(2741559) /Source="Nicolas_upshifts" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2741573..2741592) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2741609..2741612) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2742453 /Source="Nicolas_upshifts" /id="D1679" /incds=0 /nref=35 /ntot=74 /MaxReadThrough="0.613989999999999" /MaxDrop="8.59238" /score="-3.31011906" /energy="-20" /TU="NA" /idTUdmin="U2538" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2742489..2743253) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12662922, 23388828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 23388828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein required for membrane fission during spore formation" /protein_id="NP_391115.1" /db_xref="EnsemblGenomes-Gn:BSU32350" /db_xref="EnsemblGenomes-Tr:CAB15225" /db_xref="GOA:O32131" /db_xref="InterPro:IPR014197" /db_xref="SubtiList:BG13976" /db_xref="UniProtKB/Swiss-Prot:O32131" /translation="MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSLWMINGSIKP VLMDIGEMETKRIATEVIQDSIEDYMSDSENMKDMFQMNSDENGNLTTIDFNTQVVNS VKTKVTKQLQAHLKEMETHTGHSGASENIMINIPLGQVTGNSLLGNLGPKIPVRFNLI GDAFTDVKTKIKPYGINNALIDISIFVEIKVKVIIPFASKTAVVTNNVPVSIKAVQGE VPQFYNGSGGSGVTPSVQLPSSKENGADSKKEKSSK*" /label="fisB CDS" gene complement(2742489..2743253) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /label="fisB gene" downshifts complement(2742505) /Source="Nicolas_upshifts" /id="D1680" /incds=0 /nref=74 /ntot=226 /MaxReadThrough="3.15258" /MaxDrop="6.53891" /score="23.5286262" /energy="-12.4" /TU="NA" /idTUdmin="U2540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2743267..2743285) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2743275) /Source="Nicolas_upshifts" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2743301..2743306) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2743326..2743631) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391116.1" /db_xref="EnsemblGenomes-Gn:BSU32360" /db_xref="EnsemblGenomes-Tr:CAB15226" /db_xref="InterPro:IPR014931" /db_xref="InterPro:IPR036493" /db_xref="SubtiList:BG13977" /db_xref="UniProtKB/Swiss-Prot:O32132" /translation="MVNLTPIMIEGQPFTAVTVKLPKTNFMAVANDHGYIMCGALDVA LLNEKLKERGIVAGRAVGVRTIDQLLDAPLESVTYAAEDLGIKVGMSGREALLKMMK* " /label="yunC CDS" gene complement(2743326..2743631) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /label="yunC gene" downshifts complement(2743334) /Source="Nicolas_upshifts" /id="D1681" /incds=0 /nref=3 /ntot=128 /MaxReadThrough="5.18714" /MaxDrop="3.9347" /score="-2.65376612" /energy="-18.9" /TU="U2541,U2543,U2544" /idTUdmin="U2540" /TUdmin="-829" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2743645..2743664) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2743668) /Source="Nicolas_upshifts" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2743678..2743686) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2743696..2745084) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nuclease/nucleotidase/phosphoesterase" /protein_id="NP_391117.1" /db_xref="EnsemblGenomes-Gn:BSU32370" /db_xref="EnsemblGenomes-Tr:CAB15227" /db_xref="GOA:O32133" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR011240" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG13978" /db_xref="UniProtKB/Swiss-Prot:O32133" /translation="MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVF DIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFP VIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESI KETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLL ASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEK LSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKL DLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVE VETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPE FLRDLLAWKLAQ*" /label="yunD CDS" gene complement(2743696..2745084) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /label="yunD gene" CDS complement(2745104..2745925) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391118.1" /db_xref="EnsemblGenomes-Gn:BSU32380" /db_xref="EnsemblGenomes-Tr:CAB15228" /db_xref="GOA:O32134" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13979" /db_xref="UniProtKB/Swiss-Prot:O32134" /translation="MSFVILVVLGLIAGTVGSLIGLGGGIVIVPSLMFLSTVTQLFQD VTPQVAIGTSLLVIIFTGLSSTLAYIKYKTVDYKSGLIFFIGSGPGSMIGAYVSKLFN SNSFSVWFGIFMILISLSLMLKAKARPINKAHKGIIRTFQDDAGEPYTYSYQASVGIA IAFVVGFLGGLFGIGGGSLMVPAMMLLFLFPPKVAVATSMFIIFLSSMTGSVSHMISG HVNWLYALALVPGAWFGGKLGAAINRKMQTKTIVMIMRIVLILIGCQLIYEGIFS*" /label="yunE CDS" gene complement(2745104..2745925) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /label="yunE gene" CDS complement(2745943..2746791) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391119.2" /db_xref="EnsemblGenomes-Gn:BSU32390" /db_xref="EnsemblGenomes-Tr:CAB15229" /db_xref="InterPro:IPR002763" /db_xref="InterPro:IPR036520" /db_xref="SubtiList:BG13980" /db_xref="UniProtKB/Swiss-Prot:O32135" /translation="MIYIGLTGWGDHDSIYPPKTASQKKLQAYSSHFPIVELDASFYA IQPARNNEKWVKETPETFQFIVKAYQGMTGHQRGEIPFDSKEEMFDAFKVSLTPYLHS NKLAMVLFQFPPWFDCKKENVAYLRWCKHQMGDIPCALEFRNRSWFSPPFYEQTLSFM KAEGWIHSVCDEPQIGEGSVPTVLRATDENKTLVRFHGRNKQGWMKPDGGKNWREVRY LYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELLDIEYSGLAP RQLDLF*" /label="yunF CDS" gene complement(2745943..2746791) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /label="yunF gene" promotor_-35 2746310..2746315 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2746331..2746349 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2746345 /Source="Nicolas_upshifts" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2746802..2746821) /Source="Nicolas_upshift_promotors" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2746817) /Source="Nicolas_upshifts" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2746829..2747176) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391120.1" /db_xref="EnsemblGenomes-Gn:BSU32400" /db_xref="EnsemblGenomes-Tr:CAB15230" /db_xref="SubtiList:BG13981" /db_xref="UniProtKB/Swiss-Prot:O32136" /translation="MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGT IFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLRE AFSRHMNSISEET*" /label="yunG CDS" gene complement(2746829..2747176) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /label="yunG gene" promotor_-10 complement(2747189..2747208) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2747208) /Source="Nicolas_upshifts" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2747222..2747228) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2747273..2748613) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /EC_number="3.5.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoinase" /protein_id="NP_391121.1" /db_xref="EnsemblGenomes-Gn:BSU32410" /db_xref="EnsemblGenomes-Tr:CAB15231" /db_xref="GOA:O32137" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR017593" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13982" /db_xref="UniProtKB/Swiss-Prot:O32137" /translation="MAYDMVIKGAKAVTPDGVIEADIVVQNGVIAEIGSDIEASGTEI IQADGKYVFPGVIDCHVHFNEPGREDWEGFETGSQMMAAGGCTTYFDMPLNCIPSTVT AEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRPMAEAGAIGFKAFLSKSGTDEFRS VDERTLLKGMAEIAAAGKILALHAESDAITSYLQMVLANKGKVDADAYAASRPEEAEV EAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQEGLDVSVETCPHYVLFSHDDLR QRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSPCRPSLKREDNMFLSWGGIS GGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKGRLEAGCDADFVLVSMEP YTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEKVTEIDGALVVPS*" /label="pucH CDS" gene complement(2747273..2748613) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /label="pucH gene" downshifts complement(2747301) /Source="Nicolas_upshifts" /id="D1682" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.88847" /MaxDrop="3.89144" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-4796" /isTUend="FALSE" /label="downshifts" downshifts complement(2748357) /Source="Nicolas_upshifts" /id="D1683" /incds=1 /nref=1 /ntot=7 /MaxReadThrough="3.38784" /MaxDrop="3.36547" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-5852" /isTUend="FALSE" /label="downshifts" promotor_-35 2748670..2748676 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2748690..2748709 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2748692..2748710) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2748698 /Source="Nicolas_upshifts" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2748699..2748787 /Source="Nicolas_S_feature" /locus_tag="new_3328673_3328761" /HighExp="BT, Cold, S0, LBGexp, S1, Lbtran, G150, T-1.40H, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S1250" upshifts complement(2748709) /Source="Nicolas_upshifts" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2748726..2748731) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2748788..2750383 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 12374841" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 12374841; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine degradation operon" /protein_id="NP_391122.1" /db_xref="EnsemblGenomes-Gn:BSU32420" /db_xref="EnsemblGenomes-Tr:CAB15232" /db_xref="GOA:O32138" /db_xref="InterPro:IPR012914" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG13983" /db_xref="UniProtKB/Swiss-Prot:O32138" /translation="MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLH KNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAF PIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVS DILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLP IYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFN NFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFL EGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSF GISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKF YNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLG KSLKDPETTMRLRLALRMQRLIS*" /label="pucR CDS" gene 2748788..2750383 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /label="pucR gene" CDS 2750528..2751877 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease" /protein_id="NP_391123.1" /db_xref="EnsemblGenomes-Gn:BSU32430" /db_xref="EnsemblGenomes-Tr:CAB15233" /db_xref="GOA:O32139" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13984" /db_xref="UniProtKB/Swiss-Prot:O32139" /translation="MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYL LAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIA AGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYG SLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPF FQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYR AEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALA SAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIF AEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV* " /label="pucJ CDS" gene 2750528..2751877 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /label="pucJ gene" CDS 2751883..2753175 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease subunit" /protein_id="NP_391124.1" /db_xref="EnsemblGenomes-Gn:BSU32440" /db_xref="EnsemblGenomes-Tr:CAB15234" /db_xref="GOA:O32140" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13985" /db_xref="UniProtKB/Swiss-Prot:O32140" /translation="MKEQHNALQLMMLGLQHMLAMYAGAILVPLIVGAAIGLNAGQLT YLIAIDLFMCGAATLLQLWRNRYFGIGLPVVLGCTFTAVGPMISIGSTYGVPAIYGAI IAAGLIVVLAAGFFGKLVRFFPPVVTGSVVMIIGISLIPTAMNNLAGGEGSKEFGSLD NVLLGFGVTAFILLLFYFFKGFIRSIAILLGLIAGTAAAYFMGKVDFSEVLEASWLHV PSLFYFGPPTFELPAVVTMLLVAIVSLVESTGVYFALADITNRRLSEKDLEKGYRAEG LAILLGGLFNAFPYTAFSQNVGIVQLSKMKSVNVIAITGIILVAIGLVPKAAALTTVI PTPVLGGAMIVMFGMVISYGIKMLSSVDLDSQGNLLIIASSVSLGLGATTVPALFSSL SGAASVLAGSGIVIGSLTAIALHAFFQTKQPNSADIKT*" /label="pucK CDS" gene 2751883..2753175 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /label="pucK gene" CDS 2753188..2754672 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /EC_number="1.7.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12823818, 17567580, 20168977, 23760935, 28531234" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12823818, 17567580, 20168977, 23760935, 28531234; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="urate oxidase with peroxide reductase N-terminaldomain" /protein_id="NP_391125.1" /db_xref="EnsemblGenomes-Gn:BSU32450" /db_xref="EnsemblGenomes-Tr:CAB15235" /db_xref="GOA:O32141" /db_xref="InterPro:IPR002042" /db_xref="InterPro:IPR017580" /db_xref="InterPro:IPR018020" /db_xref="InterPro:IPR019842" /db_xref="InterPro:IPR036778" /db_xref="SubtiList:BG13986" /db_xref="UniProtKB/Swiss-Prot:O32141" /translation="MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSD LHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFL MLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLA DIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCE IGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHM DTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYS EIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARY VAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE IPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA*" /label="pucL CDS" gene 2753188..2754672 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /label="pucL gene" CDS 2754672..2755016 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /EC_number="3.5.2.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 16098976, 16782815, 21795808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-hydroxyisourate hydrolase; also uricase subunit" /protein_id="NP_391126.2" /db_xref="EnsemblGenomes-Gn:BSU32460" /db_xref="EnsemblGenomes-Tr:CAB15236" /db_xref="GOA:O32142" /db_xref="InterPro:IPR000895" /db_xref="InterPro:IPR014306" /db_xref="InterPro:IPR023416" /db_xref="InterPro:IPR023418" /db_xref="InterPro:IPR023419" /db_xref="InterPro:IPR036817" /db_xref="PDB:2H0E" /db_xref="PDB:2H0F" /db_xref="PDB:2H0J" /db_xref="SubtiList:BG13987" /db_xref="UniProtKB/Swiss-Prot:O32142" /translation="MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVD VPLLAGEELMSGEYVMEFHAGDYFASKNMNAADQPFLTIVTVRFQLADPDAHYHIPLL LSPFGYQVYRGS*" /label="pucM CDS" gene 2754672..2755016 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /label="pucM gene" promotor_-35 2754738..2754741 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2754759..2754778 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2754771 /Source="Nicolas_upshifts" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2754991 /Source="Nicolas_upshifts" /id="D1684" /incds=0 /nref=3 /ntot=90 /MaxReadThrough="1.80149" /MaxDrop="3.57243" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2547" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2755032..2755419) /Source="Nicolas_S_feature" /locus_tag="new_3335006_3335393_c" /HighExp="BT, S8, T2.0H, LBGstat, Cold, Etha, Sw, T1.0H, T1.30H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1251" promotor_-35 2755379..2755388 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2755401..2755420 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2755404 /Source="Nicolas_upshifts" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="upshifts" ncRNA complement(2755440..2755571) /ncRNA_class="antisense_RNA" /gene="auzJ" /locus_tag="BSU_ncRNA_2" /product="putative antisense RNA for type I YuzJ toxin" /note="Evidence 3: Putative function from multiple computational evidences" /label="auzJ ncRNA" CDS 2755440..2755571 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 20525796, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097780.1" /db_xref="EnsemblGenomes-Gn:BSU32469" /db_xref="EnsemblGenomes-Tr:CAX52686" /db_xref="GOA:C0H3Q7" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Q7" /translation="MGFYNSGGYSGNSGYSNGFGSSFALIVVLFILLIIVGAAIFNY* " /label="yuzJ CDS" gene 2755440..2755571 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /label="yuzJ gene" gene complement(2755440..2755571) /gene="auzJ" /locus_tag="BSU_ncRNA_2" /label="auzJ gene" S_feature 2755572..2755640 /Source="Nicolas_S_feature" /locus_tag="new_3335546_3335614" /HighExp="BT, B36, S8, G/S, B60, Pyr, Glucon, C30, S7, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1252" downshifts 2755607 /Source="Nicolas_upshifts" /id="D1685" /incds=0 /nref=10 /ntot=25 /MaxReadThrough="0.61379" /MaxDrop="6.43101" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2548" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2755777..2756298) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, iron-sulfur subunit" /protein_id="NP_391127.1" /db_xref="EnsemblGenomes-Gn:BSU32470" /db_xref="EnsemblGenomes-Tr:CAB15237" /db_xref="GOA:O32143" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR002888" /db_xref="InterPro:IPR006058" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017611" /db_xref="InterPro:IPR036010" /db_xref="InterPro:IPR036884" /db_xref="SubtiList:BG13988" /db_xref="UniProtKB/Swiss-Prot:O32143" /translation="MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQ LTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAF LEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRI RRELNGGRRESGF*" /label="pucE CDS" gene complement(2755777..2756298) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /label="pucE gene" CDS complement(2756289..2758526) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, substrate and molybdenumcofactor subunit" /protein_id="NP_391128.1" /db_xref="EnsemblGenomes-Gn:BSU32480" /db_xref="EnsemblGenomes-Tr:CAB15238" /db_xref="GOA:O32144" /db_xref="InterPro:IPR000674" /db_xref="InterPro:IPR008274" /db_xref="InterPro:IPR017609" /db_xref="InterPro:IPR036856" /db_xref="InterPro:IPR037165" /db_xref="SubtiList:BG13989" /db_xref="UniProtKB/Swiss-Prot:O32144" /translation="MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPH AEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVA AETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEG FQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFD IPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHP MKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGI SVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEH RIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRL SLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTA SRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKE LAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAA GPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLI AIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKG LKQWT*" /label="pucD CDS" gene complement(2756289..2758526) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /label="pucD gene" CDS complement(2758527..2759360) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, FAD-binding subunit" /protein_id="NP_391129.1" /db_xref="EnsemblGenomes-Gn:BSU32490" /db_xref="EnsemblGenomes-Tr:CAB15239" /db_xref="GOA:O32145" /db_xref="InterPro:IPR002346" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR017612" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036683" /db_xref="SubtiList:BG13990" /db_xref="UniProtKB/Swiss-Prot:O32145" /translation="MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQ LQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSD AASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEED FRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITP RRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGG E*" /label="pucC CDS" gene complement(2758527..2759360) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /label="pucC gene" CDS complement(2759357..2759974) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /EC_number="2.7.7.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11344136, 21528011; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin cofactor synthesis cytidylyl transferase" /protein_id="NP_391130.2" /db_xref="EnsemblGenomes-Gn:BSU32500" /db_xref="EnsemblGenomes-Tr:CAB15240" /db_xref="GOA:O32146" /db_xref="InterPro:IPR017615" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13991" /db_xref="UniProtKB/Swiss-Prot:O32146" /translation="MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSS RLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESM GADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLK GDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS*" /label="pucB CDS" gene complement(2759357..2759974) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /label="pucB gene" downshifts complement(2759466) /Source="Nicolas_upshifts" /id="D1686" /incds=1 /nref=3 /ntot=13 /MaxReadThrough="5.34639" /MaxDrop="3.22355" /score="-4.87239629" /energy="-9.9" /TU="U2549" /idTUdmin="U2549" /TUdmin="-3827" /isTUend="FALSE" /label="downshifts" CDS complement(2759971..2760963) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10217763, 11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217763, 11344136, 12029039; Product type f: factor" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase molybdopterin recruitmentfactor" /protein_id="NP_391131.1" /db_xref="EnsemblGenomes-Gn:BSU32510" /db_xref="EnsemblGenomes-Tr:CAB15241" /db_xref="GOA:O32147" /db_xref="InterPro:IPR003777" /db_xref="InterPro:IPR027051" /db_xref="SubtiList:BG13992" /db_xref="UniProtKB/Swiss-Prot:O32147" /translation="MGNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKG RRIGLLSGGCVEEDVFQRISALGDQLTSTLIPYDMRSEDDLSWGMGAGCNGIIHVHAE RITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAPLQDIQRTV STLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYC TSSLFPKADQLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGL LGSANRTKRLLSGKHPPSHFYSPVGLKIGAEGPEEIAVSVVAEIIQTRKRVAVV*" /label="pucA CDS" gene complement(2759971..2760963) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /label="pucA gene" S_feature complement(2760964..2761050) /Source="Nicolas_S_feature" /locus_tag="new_3340938_3341024_c" /HighExp="BT, Cold, Sw, T-1.10H, S1, C30, S0, T-0.40H, T-3.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.607" /TUlongSig="NA" /TUlongPSig="NA" /label="S1253" promotor_-10 complement(2761028..2761047) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2761050) /Source="Nicolas_upshifts" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2761061..2761066) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2761192..2762442) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 20852637, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 20852637, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(S)-ureidoglycine-glyoxylate aminotransferase (PLP-dependent)" /protein_id="NP_391132.1" /db_xref="EnsemblGenomes-Gn:BSU32520" /db_xref="EnsemblGenomes-Tr:CAB15242" /db_xref="GOA:O32148" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR024169" /db_xref="PDB:3ISL" /db_xref="SubtiList:BG13993" /db_xref="UniProtKB/Swiss-Prot:O32148" /translation="MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTG IMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLT EIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGE ACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADV IAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYAL REGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGID GESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNA GIEAGKALQAALDVYENAGRQAAV*" /label="pucG CDS" gene complement(2761192..2762442) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /label="pucG gene" CDS complement(2762459..2763697) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /EC_number="3.5.3.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11344136, 17362992, 25020232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoate amidohydrolase" /protein_id="NP_391133.1" /db_xref="EnsemblGenomes-Gn:BSU32530" /db_xref="EnsemblGenomes-Tr:CAB15243" /db_xref="GOA:O32149" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010158" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13994" /db_xref="UniProtKB/Swiss-Prot:O32149" /translation="MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQL AVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLA AMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDES GVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRR YLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNV ANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMD ERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTS ARQLEIGVRALTDLLYKLAY*" /label="pucF CDS" gene complement(2762459..2763697) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /label="pucF gene" CDS 2763920..2764057 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514002.1" /translation="MNKLSWRGDVRGTDENRNAGSPQKQDLKIWKQEISASSKGTNLQ F*" /label="hypothetical protein CDS" gene 2763920..2764057 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /label="gene" promotor_-35 2764079..2764082 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2764097..2764116 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2764098 /Source="Nicolas_upshifts" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="upshifts" CDS 2764139..2765005 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1396690, 12490701, 12883447, 16291680, 25844442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1396690, 12490701, 12883447, 16291680, 25844442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular ribonuclease" /protein_id="NP_391134.1" /db_xref="EnsemblGenomes-Gn:BSU32540" /db_xref="EnsemblGenomes-Tr:CAB15244" /db_xref="GOA:O32150" /db_xref="InterPro:IPR007346" /db_xref="SubtiList:BG13995" /db_xref="UniProtKB/Swiss-Prot:O32150" /translation="MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSG TGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKET DEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLR PADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEG DDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPF IDHPEWADEIWP*" /label="bsnA CDS" gene 2764139..2765005 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /label="bsnA gene" downshifts 2765008 /Source="Nicolas_upshifts" /id="D1687" /incds=0 /nref=48 /ntot=190 /MaxReadThrough="0.45317" /MaxDrop="6.90997" /score="25.7790712" /energy="-15.5" /TU="NA" /idTUdmin="U2550" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2765039..2766142) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23175651, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23175651, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid ABC transporter (ATP-bindingsubunit)" /protein_id="NP_391135.1" /db_xref="EnsemblGenomes-Gn:BSU32550" /db_xref="EnsemblGenomes-Tr:CAB15245" /db_xref="GOA:O32151" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR013611" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13996" /db_xref="UniProtKB/Swiss-Prot:O32151" /translation="MASLTFEHVKKSYHSQLTVKDFDLDVKDKELLVLVGPSGCGKST TLRMVAGLESISEGNLLIDGERVNDLPPKERDIAMVFQNYALYPHMTVFDNMAFGLKL RKMAKQEIAERVHAAARILEIEHLLKRKPKALSGGQRQRVALGRSIVREPKVFLMDEP LSNLDAKLRVTMRTEISKLHQRLEATIIYVTHDQTEAMTMGDRIVVMNEGEIQQVAKP HDIYHYPANLFVAGFIGSPGMNFLKGIIEQQHGELFFTNSSIRLHIPEEKAKRLKEKG YAGEQMIAGVRPEHITQMTGNDQLFDSVFQANVEVNENLGSELIVHVMAGDERLKVRL DGNTRIDAGDSIQLSVKMDHVVFFDAETEEAVY*" /label="frlP CDS" gene complement(2765039..2766142) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /label="frlP gene" downshifts complement(2765054) /Source="Nicolas_upshifts" /id="D1688" /incds=0 /nref=57 /ntot=215 /MaxReadThrough="3.04361" /MaxDrop="6.06171" /score="29.1144499" /energy="-15.5" /TU="NA" /idTUdmin="U2553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2766143..2767076) /Source="Nicolas_S_feature" /locus_tag="new_3346117_3347050_c" /HighExp="HiOs, T-5.40H, T5.0H, GM-0.1, S2, GM-0.2, GM 5, T-4.40H, T4.0H, SMM" /AntisenseName="frlR" /AntisenseCor="0.22682293682100099" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.971, 0.456, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1254" promotor_-35 2766180..2766187 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2766201..2766220 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2766211 /Source="Nicolas_upshifts" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2766262..2766268 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2766279 /Source="Nicolas_upshifts" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2766283..2766302 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2766324..2767052 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /experiment="publication(s) with functional evidences, PMID:21347729, 21398478, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21347729, 21398478, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FrlR transcriptional regulator (GntR family)" /protein_id="NP_391136.3" /db_xref="EnsemblGenomes-Gn:BSU32560" /db_xref="EnsemblGenomes-Tr:CAB15246" /db_xref="GOA:O32152" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2IKK" /db_xref="SubtiList:BG13997" /db_xref="UniProtKB/Swiss-Prot:O32152" /translation="MLNNGSSTPLYIQLKQIITDDIKKGVYSPTAKLPTENELCTKYN VSRITVRKAILDLVEEGYLIRQQGKGTFVKSPKLKRELIAVNGYSEFMESTGKKPKHH VLSHDIIPASKPIAEKLQIQPESPVVELKRILYNDDQPLTFEVTHYPLDLFPGIDTFI ADGVSMHDILKQQYKVVPTHNTKLLNVVYAQQEESKYLDCDIGDALFEIDKTAFTSND QPIYCSLFLMHTNRVTFTINSPYT*" /label="frlR CDS" gene 2766324..2767052 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /label="frlR gene" CDS complement(2767077..2767931) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 14641112, 15556630, 16153181, 21347729, 21398478, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fructoselysine kinase" /protein_id="NP_391137.1" /db_xref="EnsemblGenomes-Gn:BSU32570" /db_xref="EnsemblGenomes-Tr:CAB15247" /db_xref="GOA:O32153" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13998" /db_xref="UniProtKB/Swiss-Prot:O32153" /translation="MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIG IVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSR LRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCP YVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEAD IIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGG SSEKTRIL*" /label="frlD CDS" gene complement(2767077..2767931) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /label="frlD gene" misc_feature complement(2767264..2767283) /Source="Nicolas_upshift_promotors" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2767276) /Source="Nicolas_upshifts" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2767434..2767534) /Source="Nicolas_upshift_promotors" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2767474) /Source="Nicolas_upshifts" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2767945..2768847) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391138.1" /db_xref="EnsemblGenomes-Gn:BSU32580" /db_xref="EnsemblGenomes-Tr:CAB15248" /db_xref="GOA:O32154" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13999" /db_xref="UniProtKB/Swiss-Prot:O32154" /translation="MLPQKKTDSFRLEPVPDQHIEVKDKPRRKWYIGETSVWVFLFLY LIAIAYPLLWMVMSAFKNSDDIFEHSWSLPSSWHPENFVSAWNQGISSYFMNSVIVTA LTCVITVFISAWAAYGLSRFEFKGKGFFLVLCLGGLMLTPQVSLVPLYSIIQSLGLYN TYWALILPYAAYRIPFTIILIRSYFLSISKELEEAAYLDGCTSFGVFFRIFLPMSVPI LVTSGILTAYHTWNEFMFAIIFIDDENLRTIPAGLMQFRDALQTDWGVLLAGLTISAA PIIILFLLMQKYFVRGIASGSVKG*" /label="frlM CDS" gene complement(2767945..2768847) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /label="frlM gene" CDS complement(2768851..2769729) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391139.1" /db_xref="EnsemblGenomes-Gn:BSU32590" /db_xref="EnsemblGenomes-Tr:CAB15249" /db_xref="GOA:O32155" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14000" /db_xref="UniProtKB/Swiss-Prot:O32155" /translation="MVNQNKIIPYLFLVPALVFLLFVYIPIFENVFLSLFQWSSFSPE KTFIGLKNYVELFHDPVFYQALTNNVLYAVISIVCQVFGGLILAAVLEDKLVRKWSPF FRTVFFLPVVISMTVIALLFDFIYNPETGLLNQLLQAIGLDQLTRAWLGDDSTAMLSV IFVSQWQSVGYIAMLYIVSIQKIPDELYEAARLDGAGKIQQFFHITVPQTKEMSFVAV VMTLTGAFTVFNEPYILTGGGPGKASEVLSTFLYKSAFTKDMMGYASAIATVVLIITL ALSLMQMKFFKTGKEE*" /label="frlN CDS" gene complement(2768851..2769729) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /label="frlN gene" CDS complement(2769787..2771055) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 21347729; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose amino acid-binding lipoprotein" /protein_id="NP_391140.1" /db_xref="EnsemblGenomes-Gn:BSU32600" /db_xref="EnsemblGenomes-Tr:CAB15250" /db_xref="GOA:O32156" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG14001" /db_xref="UniProtKB/Swiss-Prot:O32156" /translation="MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEP EKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFK FIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQ KLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKD YNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEI KLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMG EKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTG VQQMLGGDMTPQQVMKAVQKAAKQVRASAE*" /label="frlO CDS" gene complement(2769787..2771055) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /label="frlO gene" promotor_no_box 2770946..2771046 /Source="Nicolas_upshift_promotors" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2771006 /Source="Nicolas_upshifts" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2771126) /Source="Nicolas_upshifts" /id="D1689" /incds=0 /nref=21 /ntot=141 /MaxReadThrough="7.96763" /MaxDrop="4.994" /score="3.53212058" /energy="-13.8" /TU="U2557" /idTUdmin="U2558" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS complement(2771136..2772122) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12618455, 15556630, 16153181, 18083814, 21347729, 21398478, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructosamine-6-P deglycase" /protein_id="NP_391141.1" /db_xref="EnsemblGenomes-Gn:BSU32610" /db_xref="EnsemblGenomes-Tr:CAB15251" /db_xref="GOA:O32157" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR024713" /db_xref="InterPro:IPR035488" /db_xref="InterPro:IPR035490" /db_xref="PDB:3EUA" /db_xref="SubtiList:BG14002" /db_xref="UniProtKB/Swiss-Prot:O32157" /translation="MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKY VFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGAL TIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQA IEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEM QWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLD AASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY*" /label="frlB CDS" gene complement(2771136..2772122) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /label="frlB gene" upshifts 2772069 /Source="Nicolas_upshifts" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2772072..2772076 /Source="Nicolas_upshift_promotors" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2772165..2772184) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2772178) /Source="Nicolas_upshifts" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2772199..2772206) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2772336) /Source="Nicolas_upshifts" /id="D1690" /incds=0 /nref=116 /ntot=274 /MaxReadThrough="0.87627" /MaxDrop="5.35981" /score="3.53212058" /energy="-13.8" /TU="NA" /idTUdmin="U2558" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2772338..2772712) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excinuclease" /protein_id="NP_391142.1" /db_xref="EnsemblGenomes-Gn:BSU32620" /db_xref="EnsemblGenomes-Tr:CAB15252" /db_xref="GOA:O32158" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR014527" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG14003" /db_xref="UniProtKB/Swiss-Prot:O32158" /translation="MIKIDIPAPNVTITERQQSANDNEPKIKPIHGFIDFHQIPRDKG GIFMFYNIHDELLFVGKARKLRQRIKKHFEDTVSPIKHHRDEVYKIEVCVVDDPMERE IYETYIINTQHSKYNIDKVFFK*" /label="yurQ CDS" gene complement(2772338..2772712) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /label="yurQ gene" upshifts complement(2772776) /Source="Nicolas_upshifts" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2772783..2772794) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2772808..2772814) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2772815..2773933) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 13914427, 16245349, 22271930, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acid oxidase" /protein_id="NP_391143.1" /db_xref="EnsemblGenomes-Gn:BSU32630" /db_xref="EnsemblGenomes-Tr:CAB15253" /db_xref="GOA:O32159" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14004" /db_xref="UniProtKB/Swiss-Prot:O32159" /translation="MKSYIIVGAGILGASTAYHLAKTGARVTVIDRKEPGQATDAAAG IVCPWLSQRRNQDWYQLAKGGARYYKDLIHQLEKDGESDTGYKRVGAISIHTDASKLD KMEERAYKRREDAPEIGDITRLSASETKKLFPILADGYESVHISGAARVNGRALCRSL LSAAEKRGATVIKGNASLLFENGTVTGVQTDTKQFAADAVIVTAGAWANEILKPLGIH FQVSFQKAQIMHFEMTDADTGSWPVVMPPSDQYILSFDNGRIVAGATHENDAGLDDLR VTAGGQHEVLSKALAVAPGLADAAAVETRVGFRPFTPGFLPVVGAVPNVQGLYAANGL GASGLTMGPFLGAELAKLVLGKQTELDLSPYDPAGALA*" /label="dadA CDS" gene complement(2772815..2773933) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /label="dadA gene" promotor_-10 complement(2773958..2773977) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2773964) /Source="Nicolas_upshifts" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2773966..2774576) /Source="Nicolas_S_feature" /locus_tag="new_3353940_3354550_c" /HighExp="G135, H2O2, G180, Paraq, G150, Oxctl, LBGexp, Salt, dia15, Diami" /AntisenseName="yurS" /AntisenseCor="-0.14245591415946501" /AntisenseRegPval="-1.7" /CDS_PredictionProba="0.95340499999999995" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1255" promotor_-35 complement(2773991..2773997) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2774030..2774039 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2774053..2774072 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2774057 /Source="Nicolas_upshifts" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2774070..2774085) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2774074) /Source="Nicolas_upshifts" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2774092..2774096) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2774092..2774238 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type f : factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054592.1" /db_xref="EnsemblGenomes-Gn:BSU32640" /db_xref="EnsemblGenomes-Tr:CAE01466" /db_xref="GOA:Q7WY59" /db_xref="SubtiList:BG14173" /db_xref="UniProtKB/Swiss-Prot:Q7WY59" /translation="MSENRHENEENRRDAAVAKVQNSGNAKVVVSVNTDQDQAQAQSQ DGED*" /label="sspG CDS" gene 2774092..2774238 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /label="sspG gene" CDS 2774238..2774513 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9852018" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391144.1" /db_xref="EnsemblGenomes-Gn:BSU32650" /db_xref="EnsemblGenomes-Tr:CAB15254" /db_xref="SubtiList:BG14005" /db_xref="UniProtKB/Swiss-Prot:O32160" /translation="MNENIIPLNRHTQEIPTTESVIKNSGNSEVHIDIHIDTMPIAFA ILCSALAAKQMTKEEFDMAYTQLREMNRENNSRSSVKQIINQETEEE*" /label="yurS CDS" gene 2774238..2774513 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /label="yurS gene" upshifts complement(2774382) /Source="Nicolas_upshifts" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2774398..2774412) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2774421..2774425) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2774493 /Source="Nicolas_upshifts" /id="D1691" /incds=0 /nref=36 /ntot=86 /MaxReadThrough="1.84089" /MaxDrop="7.4989" /score="15.0184762" /energy="-11" /TU="NA" /idTUdmin="U2560" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2774577..2774960) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10882093, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10882093, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxalase; lactoylbacillithiol lyase" /protein_id="NP_391145.1" /db_xref="EnsemblGenomes-Gn:BSU32660" /db_xref="EnsemblGenomes-Tr:CAB15255" /db_xref="GOA:O32161" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG14006" /db_xref="UniProtKB/Swiss-Prot:O32161" /translation="MKIVVTSIFVQDQDMALEFYTEKLGFIKKEDVPMGKFRWITLVS PDDQDGTELLLEPNEHPAAKEYQKKIFSEGLPATMFGVADIQKEYNRLKEKGVTFTTE PTKMGEVTIAVFDDTCGNLIQIVQK*" /label="glxB CDS" gene complement(2774577..2774960) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /label="glxB gene" S_feature complement(2774961..2775070) /Source="Nicolas_S_feature" /locus_tag="new_3354935_3355044_c" /HighExp="Salt, G180, H2O2, Paraq, G135, G150, LBGexp, LBGstat, dia15, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1256" CDS complement(2775071..2775349) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097781.1" /db_xref="EnsemblGenomes-Gn:BSU32669" /db_xref="EnsemblGenomes-Tr:CAX52687" /db_xref="GOA:C0H3Q8" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Q8" /translation="MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYD LSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE*" /label="yuzN CDS" gene complement(2775071..2775349) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /label="yuzN gene" promotor_-10 complement(2775347..2775366) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2775371) /Source="Nicolas_upshifts" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2775381..2775388) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2775512..2775618) /Source="Nicolas_S_feature" /locus_tag="new_3355486_3355592_c" /HighExp="Sw, BI, LPhT, C90, BC, M0t45, Gly, Cold, H2O2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.994" /TUlongSig="SigGF" /TUlongPSig="0.999" /label="S1257" downshifts complement(2775555) /Source="Nicolas_upshifts" /id="D1692" /incds=0 /nref=189 /ntot=303 /MaxReadThrough="3.22318" /MaxDrop="7.82118" /score="0.760415296" /energy="-10.1" /TU="U2564" /idTUdmin="U2565" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2775619..2777016) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16109955, 16431905, 16621837, 20097860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16109955, 16431905, 16621837, 20097860; Product type f: factor" /codon_start=1 /transl_table=11 /product="FeS cluster formation scaffold protein" /protein_id="NP_391146.1" /db_xref="EnsemblGenomes-Gn:BSU32670" /db_xref="EnsemblGenomes-Tr:CAB15256" /db_xref="GOA:O32162" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR010231" /db_xref="SubtiList:BG14007" /db_xref="UniProtKB/Swiss-Prot:O32162" /translation="MAKKMPDIGEYKYGFHDKDVSIFRSERGLTKEIVEEISRMKEEP QWMLDFRLKSLEHFYNMPMPQWGGDLNSLNFDEITYYVKPSERSERSWDEVPEEIKQT FDKLGIPEAEQKYLAGVSAQYESEVVYHNMKEDLEAQGIVFKDTDSALKENEDIFREH WAKVIPPTDNKFAALNSAVWSGGSFIYVPKGVKVETPLQAYFRINSENMGQFERTLII VDEEASVHYVEGCTAPVYTTNSLHSAVVEIIVKKGGYCRYTTIQNWANNVYNLVTKRT VCEENATMEWIDGNIGSKLTMKYPACILKGEGARGMTLSIALAGKGQHQDAGAKMIHL APNTSSTIVSKSISKQGGKVTYRGIVHFGRKAEGARSNIECDTLIMDNKSTSDTIPYN EILNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAV EMNRLIKFEMEGSIG*" /label="sufB CDS" gene complement(2775619..2777016) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /label="sufB gene" downshifts 2776814 /Source="Nicolas_upshifts" /id="D1693" /incds=1 /nref=1 /ntot=150 /MaxReadThrough="2.66718" /MaxDrop="3.75483" /score="-4.89805724" /energy="-5" /TU="NA" /idTUdmin="U2560" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS complement(2777037..2777480) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16877383, 20097860, 21236255, 24321018, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16877383, 20097860, 21236255, 24321018, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="iron-sulfur cluster assembly sulfur-transfer protein (Zn(2+)-dependent)" /protein_id="NP_391147.1" /db_xref="EnsemblGenomes-Gn:BSU32680" /db_xref="EnsemblGenomes-Tr:CAB15257" /db_xref="GOA:O32163" /db_xref="InterPro:IPR002871" /db_xref="PDB:1XJS" /db_xref="PDB:2AZH" /db_xref="SubtiList:BG14008" /db_xref="UniProtKB/Swiss-Prot:O32163" /translation="MSFNANLDTLYRQVIMDHYKNPRNKGVLNDSIVVDMNNPTCGDR IRLTMKLDGDIVEDAKFEGEGCSISMASASMMTQAIKGKDIETALSMSKIFSDMMQGK EYDDSIDLGDIEALQGVSKFPARIKCATLSWKALEKGVAKEEGGN*" /label="sufU CDS" gene complement(2777037..2777480) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /label="sufU gene" CDS complement(2777470..2778690) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_391148.1" /db_xref="EnsemblGenomes-Gn:BSU32690" /db_xref="EnsemblGenomes-Tr:CAB15258" /db_xref="GOA:O32164" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR010970" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="PDB:5J8Q" /db_xref="SubtiList:BG14009" /db_xref="UniProtKB/Swiss-Prot:O32164" /translation="MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKY YNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALS YARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVT SNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFF ALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTP IIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTF NLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLV EALQKTKEYFTNVF*" /label="sufS CDS" gene complement(2777470..2778690) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /label="sufS gene" CDS complement(2778690..2780003) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16109955, 16431905, 16621837, 19187533, 20097860, 28839209; Product type f: factor" /codon_start=1 /transl_table=11 /product="Fe-S cluster assembly protein SufD" /protein_id="NP_391149.1" /db_xref="EnsemblGenomes-Gn:BSU32700" /db_xref="EnsemblGenomes-Tr:CAB15259" /db_xref="GOA:O32165" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR011542" /db_xref="SubtiList:BG14010" /db_xref="UniProtKB/Swiss-Prot:O32165" /translation="MTLGTKLSVDQEYLKSFSEKHQEPAWLKNLRLQALEQAEDLPMP KPDKTKITNWNFTNFAKHTVDNEPLSSLEDLTDEVKALIDIENEDKTLYVQRDQTPAH LSLSQELKDKGVIFTDILTAAREHSDLVEKYFMKDGVKVDEHKLTALHAALVNGGAFL YVPKNVQVETPVQAVYVHESNDTALFNHVLIVAEDHSSVTYVENYISTVNPKDAVFNI ISEVITGDNASVTYGAVDNLSSGVTTYVNRRGAARGRDSKIEWALGLMNDGDTISENT TNLYGDGTYGDTKTVVVGRGEQTENFTTQIIHFGKASEGYILKHGVMKDSASSIFNGI GKIEHGASKANAEQESRVLMLSEKARGDANPILLIDEDDVTAGHAASVGRVDPIQLYY LMSRGIPKEEAERLVIYGFLAPVVNELPIEGVKKQLVSVIERKVK*" /label="sufD CDS" gene complement(2778690..2780003) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /label="sufD gene" CDS complement(2780021..2780806) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16431905, 20097860, 28839209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16431905, 20097860, 28839209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur mobilizing ABC protein, ATPase" /protein_id="NP_391150.1" /db_xref="EnsemblGenomes-Gn:BSU32710" /db_xref="EnsemblGenomes-Tr:CAB15260" /db_xref="GOA:P80866" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010230" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14011" /db_xref="UniProtKB/Swiss-Prot:P80866" /translation="MAASTLTIKDLHVEIEGKEILKGVNLEIKGGEFHAVMGPNGTGK STLSAAIMGHPKYEVTKGSITLDGKDVLEMEVDERAQAGLFLAMQYPSEISGVTNADF LRSAINARREEGDEISLMKFIRKMDENMEFLEMDPEMAQRYLNEGFSGGEKKRNEILQ LMMIEPKIAILDEIDSGLDIDALKVVSKGINKMRSENFGCLMITHYQRLLNYITPDVV HVMMQGRVVKSGGAELAQRLEAEGYDWIKQELGIEDETVGQEA*" /label="sufC CDS" gene complement(2780021..2780806) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /label="sufC gene" promotor_-10 complement(2780850..2780869) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2780851) /Source="Nicolas_upshifts" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" promotor_-35 complement(2780883..2780890) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" promotor_-10 complement(2780907..2780926) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2780916) /Source="Nicolas_upshifts" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" S_feature complement(2780918..2780999) /Source="Nicolas_S_feature" /locus_tag="new_3360892_3360973_c" /HighExp="Salt, HiOs, B60, LoTm, T1.0H, Gly, T2.0H, C30, Etha, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1258" promotor_-35 complement(2780942..2780946) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" misc_RNA complement(2780963..2781210) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /product="small regulatory RNA or messenger RNA" /experiment="publication(s) with functional evidences, PMID:18948176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176; Product type n: RNA" /label="bsrI RNA" gene complement(2780963..2781210) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /label="bsrI gene" CDS complement(2781000..2781137) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin antitoxin system" /protein_id="YP_003097782.1" /db_xref="EnsemblGenomes-Gn:BSU32719" /db_xref="EnsemblGenomes-Tr:CAX52688" /db_xref="UniProtKB/Swiss-Prot:C0H3Q9" /translation="MEKAMQLSHGIGYEEYGRRLETRMKVERQRELDYEKSKRISAGA Y*" /label="yuzK CDS" gene complement(2781000..2781137) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /label="yuzK gene" S_feature complement(2781138..2781222) /Source="Nicolas_S_feature" /locus_tag="new_3361112_3361196_c" /HighExp="HiOs, Salt, B60, S5, T1.0H, S8, HiTm, S7, T1.30H, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63415999999999995" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1259" promotor_-10 complement(2781206..2781225) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2781222) /Source="Nicolas_upshifts" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2781224..2781330) /Source="Nicolas_S_feature" /locus_tag="new_3361198_3361304_c" /HighExp="S8, S5, S7, S6, S4, BT, ferm, nit, S3, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1260" promotor_-35 complement(2781241..2781244) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2781331..2781708) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391151.1" /db_xref="EnsemblGenomes-Gn:BSU32720" /db_xref="EnsemblGenomes-Tr:CAB15261" /db_xref="GOA:O32166" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG14012" /db_xref="UniProtKB/Swiss-Prot:O32166" /translation="MEGFSLNQDRGSMQDALKQYKHGLGTFEQKMPLMGRKFNEFTEQ CFAGNSLTEREKQLIALGIAINAQDEYCMIYHTKGCLDQGASEENILEAVSVAAAFGG GAAFSQGVTVVQQCIEEFGNTTH*" /label="yurZ CDS" gene complement(2781331..2781708) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /label="yurZ gene" promotor_-10 complement(2781725..2781736) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-10" upshifts complement(2781731) /Source="Nicolas_upshifts" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="upshifts" promotor_-35 complement(2781750..2781756) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-35" CDS complement(2781793..2782617) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 16109943, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 16109943, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, substrate binding lipoprotein" /protein_id="NP_391152.1" /db_xref="EnsemblGenomes-Gn:BSU32730" /db_xref="EnsemblGenomes-Tr:CAB15262" /db_xref="GOA:O32167" /db_xref="InterPro:IPR004872" /db_xref="PDB:4GOT" /db_xref="SubtiList:BG14013" /db_xref="UniProtKB/Swiss-Prot:O32167" /translation="MKKLFLGALLLVFAGVMAACGSNNGAESGKKEIVVAATKTPHAE ILKEAEPLLKEKGYTLKVKVLSDYKMYNKALADKEVDANYFQHIPYLEQEMKENTDYK LVNAGAVHLEPFGIYSKTYKSLKDLPDGATIILTNNVAEQGRMLAMLENAGLITLDSK VETVDATLKDIKKNPKNLEFKKVAPELTAKAYENKEGDAVFINVNYAIQNKLNPKKDA IEVESTKNNPYANIIAVRKGEEDSAKIKALMEVLHSKKIKDFIEKKYDGAVLPVSE*" /label="metQ CDS" gene complement(2781793..2782617) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /label="metQ gene" downshifts complement(2781801) /Source="Nicolas_upshifts" /id="D1694" /incds=0 /nref=167 /ntot=246 /MaxReadThrough="2.13581" /MaxDrop="6.33517" /score="28.8468637" /energy="-12.6" /TU="NA" /idTUdmin="U2569" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2781950) /Source="Nicolas_upshifts" /id="D1695" /incds=1 /nref=2 /ntot=171 /MaxReadThrough="6.93658" /MaxDrop="2.3341" /score="28.8468637" /energy="-12.6" /TU="U2569" /idTUdmin="U2569" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-35 2781977..2781982 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2781998..2782016 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2782000 /Source="Nicolas_upshifts" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2782631..2783299) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 15849754, 16850406, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 15849754, 16850406, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, permease component" /protein_id="NP_391153.1" /db_xref="EnsemblGenomes-Gn:BSU32740" /db_xref="EnsemblGenomes-Tr:CAB15263" /db_xref="GOA:O32168" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14014" /db_xref="UniProtKB/Swiss-Prot:O32168" /translation="MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLF LTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALV IGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAI ALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNI IDKR*" /label="metP CDS" gene complement(2782631..2783299) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /label="metP gene" CDS complement(2783292..2784317) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 17038623; Product type t: transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter (ATP-binding protein)" /protein_id="NP_391154.1" /db_xref="EnsemblGenomes-Gn:BSU32750" /db_xref="EnsemblGenomes-Tr:CAB15264" /db_xref="GOA:O32169" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017908" /db_xref="InterPro:IPR018449" /db_xref="InterPro:IPR026253" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14015" /db_xref="UniProtKB/Swiss-Prot:O32169" /translation="MINLQDVSKVYKSKHGDVNAVQNVSLSIKKGEIFGIIGYSGAGK SSLIRLLNGLEKPTSGTVEVAGTKINEVNGRGLRKARHEISMIFQHFNLLWSRTVRDN IMFPLEIAGVKKSERIKRANELIKLVGLEGKEKSYPSQLSGGQKQRVGIARALANNPK VLLCDEATSALDPQTTDSILDLLSDINERLGLTIVLITHEMHVIRKICNRVAVMENGK VVEEGEVLDVFKNPKEQMTKRFVQQVTEPEETKETLQHLLDDTASGKMVQLTFVGESA EQPLITEMIRNFNVSVNILQGKISQTKDGAYGSLFIHIDGDEEEVQNVIRFINDKQVK AEVITNV*" /label="metN CDS" gene complement(2783292..2784317) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /label="metN gene" S_feature complement(2784318..2784422) /Source="Nicolas_S_feature" /locus_tag="new_3364292_3364396_c" /HighExp="MG 5, MG t5, MG 10, BMM, MG-0.2, GM 25, MG-0.1, MG 15, M9-exp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1261" misc_RNA complement(2784423..2784529) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswH RNA" gene complement(2784423..2784529) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /label="mswH gene" downshifts 2784492 /Source="Nicolas_upshifts" /id="D1696" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="1.54417" /MaxDrop="5.51028" /score="-1.70178746" /energy="-11.2" /TU="NA" /idTUdmin="U2568" /TUdmin=2420 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2784556..2784575) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2784568) /Source="Nicolas_upshifts" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2784570..2784643) /Source="Nicolas_S_feature" /locus_tag="new_3364544_3364617_c" /HighExp="M9-stat, S2, LoTm, T5.0H, HiOs, B60, S3, T3.30H, LPhT, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1262" promotor_-35 complement(2784591..2784598) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2784644..2784988) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391155.1" /db_xref="EnsemblGenomes-Gn:BSU32760" /db_xref="EnsemblGenomes-Tr:CAB15265" /db_xref="InterPro:IPR003033" /db_xref="InterPro:IPR036527" /db_xref="SubtiList:BG14016" /db_xref="UniProtKB/Swiss-Prot:O32170" /translation="MEKAEVLEDEYQHLFLKPLLNASTLLITFQGEAEALTVSINEQG EMKKVSPPQTSNLTFYGNQTEIIDLLHGDISLQHLIQSGSLKVKGSFRALLKLEAILW LTNGFFQRILKN*" /label="yusD CDS" gene complement(2784644..2784988) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /label="yusD gene" S_feature complement(2784989..2785094) /Source="Nicolas_S_feature" /locus_tag="new_3364963_3365068_c" /HighExp="LPhT, HiOs, M9-stat, dia5, T2.0H, Diami, T1.30H, T0.30H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA, SigA" /TUshortPSig="1, 0.996, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S1263" CDS complement(2785095..2785415) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_391156.1" /db_xref="EnsemblGenomes-Gn:BSU32770" /db_xref="EnsemblGenomes-Tr:CAB15266" /db_xref="GOA:O32171" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14017" /db_xref="UniProtKB/Swiss-Prot:O32171" /translation="MKELQEHELDHIEDDVYLLYLYTPFCGTCQLASKMLTVVKEMLP DVAFYQNNVNYSPTFAKAYQIESVPCFLLFKGGKMVERGYAFHSVSYLYELIKQKSSS ASHL*" /label="yusE CDS" gene complement(2785095..2785415) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /label="yusE gene" CDS complement(2785417..2785857) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12794188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease" /protein_id="NP_391157.1" /db_xref="EnsemblGenomes-Gn:BSU32780" /db_xref="EnsemblGenomes-Tr:CAB15267" /db_xref="GOA:O32172" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG14018" /db_xref="UniProtKB/Swiss-Prot:O32172" /translation="MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEK IESVLNEPMRIICTNGTISQLRLEELADELYDKDVYILVDADESGEKLRKQLKREFNE ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV*" /label="yusF CDS" gene complement(2785417..2785857) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /label="yusF gene" CDS complement(2785857..2786093) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391158.1" /db_xref="EnsemblGenomes-Gn:BSU32790" /db_xref="EnsemblGenomes-Tr:CAB15268" /db_xref="InterPro:IPR020140" /db_xref="SubtiList:BG14019" /db_xref="UniProtKB/Swiss-Prot:O32173" /translation="MAFDKQKLDVTNDVTGRFQNGRLSLYHDNEMIGQMTSMNEYELK SGYSFENEKFYKTADVVSGDDAKYVDCDYENGWC*" /label="yusG CDS" gene complement(2785857..2786093) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /label="yusG gene" downshifts complement(2785869) /Source="Nicolas_upshifts" /id="D1697" /incds=0 /nref=35 /ntot=245 /MaxReadThrough="6.00162" /MaxDrop="3.9147" /score="-1.53913693" /energy="-11" /TU="U2570,U2571,U2572" /idTUdmin="U2574" /TUdmin=723 /isTUend="FALSE" /label="downshifts" upshifts complement(2786108) /Source="Nicolas_upshifts" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2786113..2786124) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2786139..2786145) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2786149..2786532) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 20882995, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine cleavage system protein H (lipoyl acceptor protein)" /protein_id="NP_391159.1" /db_xref="EnsemblGenomes-Gn:BSU32800" /db_xref="EnsemblGenomes-Tr:CAB15269" /db_xref="GOA:O32174" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR002930" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR017453" /db_xref="InterPro:IPR033753" /db_xref="SubtiList:BG14020" /db_xref="UniProtKB/Swiss-Prot:O32174" /translation="MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELP EVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIV VEPSDASEIEKLMTAEQYEEMTQED*" /label="gcvH CDS" gene complement(2786149..2786532) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /label="gcvH gene" promotor_-10 complement(2786559..2786578) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-10" upshifts complement(2786570) /Source="Nicolas_upshifts" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="upshifts" promotor_-35 complement(2786591..2786598) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-35" CDS complement(2786599..2786955) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /EC_number="1.20.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with thioredoxin domain and regulator domain" /protein_id="NP_391160.1" /db_xref="EnsemblGenomes-Gn:BSU32810" /db_xref="EnsemblGenomes-Tr:CAB15270" /db_xref="GOA:O32175" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14021" /db_xref="UniProtKB/Swiss-Prot:O32175" /translation="MSLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELK ALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHMSEDEQLELLASDGMLIKRPLTTDGE KVTVGFKEDQFEENWA*" /label="yusI CDS" gene complement(2786599..2786955) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /label="yusI gene" promotor_-10 complement(2786978..2786997) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-10" upshifts complement(2786988) /Source="Nicolas_upshifts" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="upshifts" promotor_-35 complement(2787011..2787016) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-35" CDS complement(2787066..2788850) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase (FAD dependent)" /protein_id="NP_391161.1" /db_xref="EnsemblGenomes-Gn:BSU32820" /db_xref="EnsemblGenomes-Tr:CAB15271" /db_xref="GOA:O32176" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG14022" /db_xref="UniProtKB/Swiss-Prot:O32176" /translation="MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDY IEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKF SRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVST GPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGA SKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMS QFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVE RAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPG SGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVL RTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRK LTRVTPKNVIQKKREAAAGIFEAEKYTV*" /label="fadE CDS" gene complement(2787066..2788850) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /label="fadE gene" downshifts complement(2787076) /Source="Nicolas_upshifts" /id="D1698" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="4.78872" /MaxDrop="6.88218" /score="31.8022607" /energy="-16.4" /TU="U2574" /idTUdmin="U2576" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2788865..2790040) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /EC_number="2.3.1.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acyltransferase" /protein_id="NP_391162.1" /db_xref="EnsemblGenomes-Gn:BSU32830" /db_xref="EnsemblGenomes-Tr:CAB15272" /db_xref="GOA:O32177" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG14023" /db_xref="UniProtKB/Swiss-Prot:O32177" /translation="MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGG YEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAE KIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGV SREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGV RPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRS FAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEE KVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC* " /label="fadA CDS" gene complement(2788865..2790040) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /label="fadA gene" CDS complement(2790051..2792420) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /EC_number="1.1.1.35" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17189250, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase" /protein_id="NP_391163.2" /db_xref="EnsemblGenomes-Gn:BSU32840" /db_xref="EnsemblGenomes-Tr:CAB15273" /db_xref="GOA:O32178" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14024" /db_xref="UniProtKB/Swiss-Prot:O32178" /translation="MHKHIRKAAVLGSGVMGSGIAAHLANIGIPVLLLDIVPNDLTKE EEKKGLTKDSSEVRSRLSRQAMKKLLKQKPAPLTSAKNTSYITPGNLEDDAEKLKEAD WIIEVVVENLEVKKKIFALVDEHRKTGSIVSSNTSGISVQEMAEGRSDDFKAHFLGTH FFNPARYLKLLEIIPIKETDPDILKFMTAFGENVLGKGVVTAKDTPNFIANRIGTYGL LVTVQEMLKGGYQVGEVDSITGPLIGRPKSATFRTLDVVGLDTFAHVARNVYDKADGD EKEVFRIPSFMNDMLEKGWIGSKAGQGFYKKEGKTIYELDPVTLTYGERTKMKSPALE AAKQAKGTKAKMKALIYSDDRAGRLLWNITSQTLLYSAELLGEIADDIHAIDQAMKWG FGWELGPFEMWDAIGLKQSAEKLEQLGADMPGWIKEMLDKGNETFYIKENGTVFYYDR GEYRAVKENKKRIHLQALKETKGVIAKNSGASLIDLGDDVALLEFHSKSNAIGLDIIQ MIHKGLEETERNYKGLVIGNQGKNFCVGANLAMILMEVQDDNFLEVDFVIRRFQETMM KIKYSAKPVVAAPFGMTLGGGTEACLPAARIQAASEAYMGLVESGVGLIPGGGGNKEL YINHLRRGHDPMNAAMKTFETIAMAKVSASAQEAREMNILKETDQISVNQDHLLYDAK QLAASLYDTGWRPPVKEKVKVPGETGYAALLLGAEQMKLSGYISEHDFKIAKKLAYVI AGGKVPFGTEVDEEYLLEIEREAFLSLSGEAKSQARMQHMLVKGKPLRN*" /label="fadN CDS" gene complement(2790051..2792420) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /label="fadN gene" promotor_-35 2791839..2791844 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2791859..2791877 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2791862 /Source="Nicolas_upshifts" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2792488..2792507) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-10" upshifts complement(2792491) /Source="Nicolas_upshifts" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="upshifts" S_feature complement(2792499..2792765) /Source="Nicolas_S_feature" /locus_tag="new_3372473_3372739_c" /HighExp="S8, S6, S7, BT, B36, G/S, B60, S5, Pyr, S3" /AntisenseName="yuzL" /AntisenseCor="0.77564732124057401" /AntisenseRegPval="-54.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1264" promotor_-35 complement(2792521..2792528) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-35" promotor_-35 2792546..2792552 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2792567..2792578 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2792589 /Source="Nicolas_upshifts" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="upshifts" CDS 2792595..2792741 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17189250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097783.1" /db_xref="EnsemblGenomes-Gn:BSU32849" /db_xref="EnsemblGenomes-Tr:CAX52689" /db_xref="InterPro:IPR025625" /db_xref="UniProtKB/Swiss-Prot:C0H3R0" /translation="MVREKKNPSSAAVSAASVKGDAGPTQHYGGGKRTSQNQQYKKHN MGQS*" /label="yuzL CDS" gene 2792595..2792741 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /label="yuzL gene" S_feature 2792742..2793768 /Source="Nicolas_S_feature" /locus_tag="new_3372716_3373742" /HighExp="S8, S5, S7, S4, S6, nit, ferm, T5.0H, S3, LoTm" /AntisenseName="fadM" /AntisenseCor="0.80952501049450498" /AntisenseRegPval="-63" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1265" CDS complement(2792766..2793674) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /EC_number="1.5.5.2" /function="3.2: Degradation" /experiment="publication(s) with functional evidences, PMID:17189250, 17536821, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 17536821, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline dehydrogenase 1" /protein_id="NP_391164.1" /db_xref="EnsemblGenomes-Gn:BSU32850" /db_xref="EnsemblGenomes-Tr:CAB15274" /db_xref="GOA:O32179" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG14025" /db_xref="UniProtKB/Swiss-Prot:O32179" /translation="MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTV KRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLD LSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAY LYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTA VATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTD WFSYFMRRIAERPANAAFVLKGILKK*" /label="putM CDS" gene complement(2792766..2793674) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /label="putM gene" S_feature complement(2793675..2794197) /Source="Nicolas_S_feature" /locus_tag="new_3373649_3374171_c" /HighExp="S8, S6, S7, BT, B36, B60, G/S, Pyr, S5, SMMPr" /AntisenseName="yuzM" /AntisenseCor="0.77827902986544495" /AntisenseRegPval="-55.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1266" CDS 2793769..2794014 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097784.1" /db_xref="EnsemblGenomes-Gn:BSU32859" /db_xref="EnsemblGenomes-Tr:CAX52690" /db_xref="InterPro:IPR012347" /db_xref="UniProtKB/Swiss-Prot:C0H3R1" /translation="MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQ DQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ*" /label="yuzM CDS" gene 2793769..2794014 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /label="yuzM gene" CDS 2794027..2794359 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat-like protein" /protein_id="NP_391165.1" /db_xref="EnsemblGenomes-Gn:BSU32860" /db_xref="EnsemblGenomes-Tr:CAB15275" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG14026" /db_xref="UniProtKB/Swiss-Prot:O32180" /translation="MNQQNQKISNPQTPVPTTSEMNDRDFVNELLTTEKYMTTAYCTA LHEFSHESLYQDIQSIFDESQKAQRKLYDLMFQYGWYSVEAEDSQKLQQSYQKFQQTI QQQSPYQQ*" /label="yusN CDS" gene 2794027..2794359 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /label="yusN gene" promotor_-10 complement(2794180..2794199) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2794197) /Source="Nicolas_upshifts" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2794213..2794222) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2794348 /Source="Nicolas_upshifts" /id="D1699" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="2.684" /MaxDrop="5.38418" /score="9.88876972" /energy="-10.2" /TU="NA" /idTUdmin="U2575" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2794420..2794427 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2794441..2794460 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2794452 /Source="Nicolas_upshifts" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="upshifts" CDS 2794518..2794985 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12923086, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923086, 19286808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, low level antibiotic resistance)" /protein_id="NP_391166.1" /db_xref="EnsemblGenomes-Gn:BSU32870" /db_xref="EnsemblGenomes-Tr:CAB15276" /db_xref="GOA:O32181" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1S3J" /db_xref="SubtiList:BG14027" /db_xref="UniProtKB/Swiss-Prot:O32181" /translation="MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLA SLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGD IKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG*" /label="mdtR CDS" gene 2794518..2794985 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /label="mdtR gene" CDS 2794982..2796607 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19286808; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_391167.1" /db_xref="EnsemblGenomes-Gn:BSU32880" /db_xref="EnsemblGenomes-Tr:CAB15277" /db_xref="GOA:O32182" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14028" /db_xref="UniProtKB/Swiss-Prot:O32182" /translation="MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDL GGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMT ELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWI VDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLAL SFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGF FMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQ IITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEEL GVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKG MIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAV FTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH*" /label="mdtP CDS" gene 2794982..2796607 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /label="mdtP gene" downshifts 2796592 /Source="Nicolas_upshifts" /id="D1700" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="0.3188" /MaxDrop="5.64223" /score="42.0555168" /energy="-17.7" /TU="NA" /idTUdmin="U2577" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2796643..2797026) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25219626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydratase of unidentified specificity (tautomerase superfamily)" /protein_id="NP_391168.1" /db_xref="EnsemblGenomes-Gn:BSU32890" /db_xref="EnsemblGenomes-Tr:CAB15278" /db_xref="GOA:O32183" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG14029" /db_xref="UniProtKB/Swiss-Prot:O32183" /translation="MPFVQIHLRSGRSEVWLQKLSRTIHQSMIEEINVPEDDYFQVIR QYEKSEFFYDPFYLQVERTDELIYIHFTLKQSRTTEQKKALYRSIASRIHSELGVRKE DVFIMLAGNQDEDWSFGNGRAQMIE*" /label="yusQ CDS" gene complement(2796643..2797026) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /label="yusQ gene" CDS complement(2797045..2797434) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15294834; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_391169.1" /db_xref="EnsemblGenomes-Gn:BSU32900" /db_xref="EnsemblGenomes-Tr:CAB15279" /db_xref="GOA:O32184" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14030" /db_xref="UniProtKB/Swiss-Prot:O32184" /translation="MKGMFFCARAVVPFMKKSKDGAIVNVGSIAGITGAGSSMPYAVS KSAVHGLTKSLAHALAPEIRVSGVAPGAVATRWWAGREEKMKSMIGSLLLQCIAEPDD VAKLICSLIEQESLTGQIITIDSGQTL*" /label="yusR CDS" gene complement(2797045..2797434) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /label="yusR gene" CDS complement(2797456..2797785) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved enzyme of unknown function" /protein_id="NP_391170.1" /db_xref="EnsemblGenomes-Gn:BSU32910" /db_xref="EnsemblGenomes-Tr:CAB15280" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14031" /db_xref="UniProtKB/Swiss-Prot:O32185" /translation="MNVLNKIALVTGGGTGIGKAASMELAKRGAIVAVNYSRSQSEAE ETVEMIQKAGGQAFAIQADVSKNSDVQDMIQAIVNTHGTVDILVNNASITRHIPMDDL EAATEDV*" /label="yusS CDS" gene complement(2797456..2797785) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /label="yusS gene" promotor_-10 complement(2797820..2797839) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2797827..2797834 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2797834) /Source="Nicolas_upshifts" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2797849..2797868 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2797853..2797860) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2797859 /Source="Nicolas_upshifts" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="upshifts" CDS 2797919..2798806 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591, 17526699, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591, 17526699, 27965289; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown specificity(LysR family)" /protein_id="NP_391171.1" /db_xref="EnsemblGenomes-Gn:BSU32920" /db_xref="EnsemblGenomes-Tr:CAB15281" /db_xref="GOA:O32186" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14032" /db_xref="UniProtKB/Swiss-Prot:O32186" /translation="MESGDLRVFQMVAREGTITKAALQLGYVQSNVTARIQQLEAELG TTLFLRHNRGMTLSASGKLLLDYANKIIGLLDEASKALSSSAEPSGPLMIGCTQTTAA VRLPKLLASYYEEHPNVQLSLTTGHTQFLLDKVLRYELDGAFIGCECHHPELESYPAF EEEPVVVSAASVPDVEEAITKPILVYSTGCSYRETLEKWLRSVGVTQPVIMEFGTLEA IIGGVTAGLGISLLPRTVVQKHEAEGSIRLYPLPEALSQMKTEFIVRKDSFISSALRT FMDSFTPVKTAESQKSSLL*" /label="yusT CDS" gene 2797919..2798806 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /label="yusT gene" CDS complement(2798826..2799113) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22078549" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391172.1" /db_xref="EnsemblGenomes-Gn:BSU32930" /db_xref="EnsemblGenomes-Tr:CAB15282" /db_xref="InterPro:IPR020393" /db_xref="SubtiList:BG14033" /db_xref="UniProtKB/Swiss-Prot:O32187" /translation="MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKE EVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ*" /label="yusU CDS" gene complement(2798826..2799113) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /label="yusU gene" downshifts complement(2798838) /Source="Nicolas_upshifts" /id="D1701" /incds=0 /nref=113 /ntot=280 /MaxReadThrough="1.05563" /MaxDrop="5.97768" /score="17.1690128" /energy="-13.2" /TU="NA" /idTUdmin="U2580" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2799138..2799965) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 24847778, 25288929; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III)-siderophore transporter (ATP binding component)" /protein_id="NP_391173.1" /db_xref="EnsemblGenomes-Gn:BSU32940" /db_xref="EnsemblGenomes-Tr:CAB15283" /db_xref="GOA:O32188" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14034" /db_xref="UniProtKB/Swiss-Prot:O32188" /translation="MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGK STLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ GRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQET DIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDK RIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG* " /label="feuV CDS" gene complement(2799138..2799965) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /label="feuV gene" downshifts complement(2799154) /Source="Nicolas_upshifts" /id="D1702" /incds=0 /nref=2 /ntot=77 /MaxReadThrough="5.36684" /MaxDrop="3.19022" /score="11.3999731" /energy="-19.8" /TU="U2580" /idTUdmin="U2581" /TUdmin=220 /isTUend="FALSE" /label="downshifts" S_feature complement(2799966..2800103) /Source="Nicolas_S_feature" /locus_tag="new_3379940_3380077_c" /HighExp="T-5.40H, Paraq, H2O2, GM-0.2, HiOs, GM 5, dia15, GM 25, T-3.40H, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1267" promotor_-10 complement(2800088..2800107) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2800103) /Source="Nicolas_upshifts" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2800123..2800126) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2800183..2800620) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26497467; Product type m : membrane component" /codon_start=1 /transl_table=11 /product="spore lipoprotein" /protein_id="NP_391174.1" /db_xref="EnsemblGenomes-Gn:BSU32950" /db_xref="EnsemblGenomes-Tr:CAB15284" /db_xref="InterPro:IPR025623" /db_xref="SubtiList:BG14035" /db_xref="UniProtKB/Swiss-Prot:O32189" /translation="MHLIRAAGAVCLAVVLIAGCRFNEDQHQAEGENTAVTQLKSVPY SNFSLRVSYGDGEHNRYEGIYTKNGTQEKAEIQDKLSGVNQEGEEALDEMKMILSELS VTDQMAETEVIHSVLAAFNLDSHYDHIDLKLKLKDGSIREIKK*" /label="cotNW CDS" gene complement(2800183..2800620) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /label="cotNW gene" promotor_-10 complement(2800644..2800662) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-10" upshifts complement(2800650) /Source="Nicolas_upshifts" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="upshifts" promotor_-35 complement(2800678..2800683) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-35" CDS complement(2800730..2802238) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; C-terminal part of YusY" /db_xref="SubtiList:BG14037" /translation="GLMNRLSADFQSSLVTLDHKLVDINQDVWNELLTKPGLRDVSYI LNERRQRVAEKLSPGKEKLIGNLAVDGYHAWSDLYNMVVGKMTIPYEENGENKQLSVG QAENMMDHQDRTVRKTVYERFRQAWESKQDIFSSTLNHLAGFRLETYKARGWENVLKE PLQINRMKKETLDTMWQVITENKKPFVQFLNRKASMLGLEKLSWYDVEAPIGSDGKVY SYDEAANIITSQFSTFGKKLSSFTEKAFRDGWIEAEDRSGKRVGGFCTSFPDSGESRI FMTFSGSASNVSTLAHELGHAFHQEAMLNVRPLNRSYAMNVAETASTFAEMIVADATV QQAETREEKLVLLEDKVQRSVAFFMNIHARFLFETRFYEERKRGVVPASRLNELMEEA QREAYCNALEEYHPLFWASKLHFHITRVPFYNFPYTFGYLFSLGIYALALEEKDTFEE KYMALLRDTASMTVEDLAMKHLGADITKRDFWENAIKLAVRDAETFLQMTES*" /label="yusYc CDS" gene complement(2800730..2802238) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /pseudo /label="yusYc gene" downshifts complement(2800751) /Source="Nicolas_upshifts" /id="D1703" /incds=0 /nref=125 /ntot=240 /MaxReadThrough="2.57385" /MaxDrop="6.5698" /score="6.83314975" /energy="-12" /TU="NA" /idTUdmin="U2582" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(2802229..2802525) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; N-terminal part of YusY" /translation="MALQGVGQRWDLDSFFKGGSQSEEFKGYIEKLSQSLRAFQDRTD AFQVPESPEEAEGLTALLDLFEQTSVKLQQAGAFVACLQAQNINDQKAIEHQAS*" /label="yusYn CDS" gene complement(2802229..2802525) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /pseudo /label="yusYn gene" promotor_-10 complement(2802548..2802567) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2802564) /Source="Nicolas_upshifts" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2802582..2802585) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2802602..2802607 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2802619..2802638 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2802619 /Source="Nicolas_upshifts" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="upshifts" CDS 2802659..2803501 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative short-chain acyl dehydrogenase" /protein_id="NP_391177.1" /db_xref="EnsemblGenomes-Gn:BSU32980" /db_xref="EnsemblGenomes-Tr:CAB15287" /db_xref="GOA:P37959" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10863" /db_xref="UniProtKB/Swiss-Prot:P37959" /translation="MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRE LAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPME HFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALE GFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYV QKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKK KLFS*" /label="yusZ CDS" gene 2802659..2803501 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /label="yusZ gene" promotor_-35 2803031..2803037 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-35" promotor_-10 2803052..2803063 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-10" upshifts 2803060 /Source="Nicolas_upshifts" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="upshifts" promotor_-35 2803528..2803535 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2803544 /Source="Nicolas_upshifts" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2803547..2803566 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2803591..2804052 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 8709848, 21057011, 22194458, 24123749, 28434086" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 8709848, 21057011, 22194458, 24123749, 28434086; Product type f : factor" /codon_start=1 /transl_table=11 /product="metalloregulation DNA-binding stress protein" /protein_id="NP_391178.1" /db_xref="EnsemblGenomes-Gn:BSU32990" /db_xref="EnsemblGenomes-Tr:CAB15288" /db_xref="GOA:P37960" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="PDB:2CHP" /db_xref="SubtiList:BG10864" /db_xref="UniProtKB/Swiss-Prot:P37960" /translation="MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFF TLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQ ALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG*" /label="mrgA CDS" gene 2803591..2804052 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /label="mrgA gene" downshifts 2804028 /Source="Nicolas_upshifts" /id="D1704" /incds=0 /nref=234 /ntot=274 /MaxReadThrough="1.7919" /MaxDrop="8.26581" /score="36.5549876" /energy="-13.3" /TU="NA" /idTUdmin="U2583" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2804096..2805472) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423; Product type f: factor" /codon_start=1 /transl_table=11 /product="protease-associated chaperone for the extracytoplasmic folding and quality control of exported proteins" /protein_id="NP_391180.2" /db_xref="EnsemblGenomes-Gn:BSU33000" /db_xref="EnsemblGenomes-Tr:CAB15290" /db_xref="GOA:Q9R9I1" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14155" /db_xref="UniProtKB/Swiss-Prot:Q9R9I1" /translation="MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSY EAGRQETASALEMEKQETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQA TETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDL AVLEISGKNVKKVASFGDSSQLRTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVD TTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSESGVESLGFAIPSNDV EPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSP AEKAGIKSEDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLT KQTESSSS*" /label="htrB CDS" gene complement(2804096..2805472) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /label="htrB gene" downshifts complement(2804104) /Source="Nicolas_upshifts" /id="D1705" /incds=0 /nref=206 /ntot=257 /MaxReadThrough="1.84997" /MaxDrop="6.39104" /score="17.1953741" /energy="-11.2" /TU="U2586" /idTUdmin="U2586" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2805473..2805644) /Source="Nicolas_S_feature" /locus_tag="new_3385447_3385618_c" /HighExp="SMMPr, T-0.40H, T-1.10H, M9-tran, T-1.40H, T1.0H, T0.30H, T1.30H, Etha, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67259999999999998" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1268" promotor_-10 complement(2805625..2805644) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2805644) /Source="Nicolas_upshifts" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2805655..2805662) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2805705..2805724) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-10" misc_feature 2805715..2805734 /Source="Nicolas_upshift_promotors" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2805717 /Source="Nicolas_upshifts" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2805723) /Source="Nicolas_upshifts" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="upshifts" S_feature complement(2805725..2806788) /Source="Nicolas_S_feature" /locus_tag="new_3385699_3386762_c" /HighExp="T1.0H, T0.30H, T1.30H, C30, T2.0H, G135, G180, T2.30H, ferm, G150" /AntisenseName="cssR" /AntisenseCor="0.115381389160342" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1269" promotor_-35 complement(2805739..2805746) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-35" CDS 2805750..2806427 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type r: regulator" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component response regulator" /protein_id="NP_391181.1" /db_xref="EnsemblGenomes-Gn:BSU33010" /db_xref="EnsemblGenomes-Tr:CAB15291" /db_xref="GOA:O32192" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14131" /db_xref="UniProtKB/Swiss-Prot:O32192" /translation="MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTP SPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISK PFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKE FDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGF GYRMMSS*" /label="cssR CDS" gene 2805750..2806427 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /label="cssR gene" CDS 2806424..2807779 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component sensor histidine kinase" /protein_id="NP_391182.2" /db_xref="EnsemblGenomes-Gn:BSU33020" /db_xref="EnsemblGenomes-Tr:CAB15292" /db_xref="GOA:O32193" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14132" /db_xref="UniProtKB/Swiss-Prot:O32193" /translation="MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTT IENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSS FIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLA YTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKD EIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDL ENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARK ELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKND GPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVP K*" /label="cssS CDS" gene 2806424..2807779 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /label="cssS gene" S_feature complement(2806878..2807806) /Source="Nicolas_S_feature" /locus_tag="new_3386852_3387780_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, ferm, C30, LPhT, T-1.10H, Lbstat" /AntisenseName="cssS" /AntisenseCor="0.27217686232372901" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigD, SigH, SigA" /TUshortPSig="1, 0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1270" downshifts 2807747 /Source="Nicolas_upshifts" /id="D1706" /incds=0 /nref=61 /ntot=203 /MaxReadThrough="0.95076" /MaxDrop="4.47937" /score="13.0972324" /energy="-9.7" /TU="NA" /idTUdmin="U2587" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2807807..2807971) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /experiment="publication(s) with functional evidences, PMID:21378193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21378193; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpxA degradation" /protein_id="YP_003097785.1" /db_xref="EnsemblGenomes-Gn:BSU33029" /db_xref="EnsemblGenomes-Tr:CAX52691" /db_xref="GOA:O32302" /db_xref="UniProtKB/Swiss-Prot:O32302" /translation="MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTN YRDFNGYSFT*" /label="spxO CDS" gene complement(2807807..2807971) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /label="spxO gene" promotor_-35 2807995..2808002 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2808016..2808035 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2808020..2808039) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2808026..2808138 /Source="Nicolas_S_feature" /locus_tag="new_3388000_3388112" /HighExp="dia5, Diami, T0.30H, T-0.40H, T0.0H, dia15, Salt, ferm, G135, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1271" upshifts 2808026 /Source="Nicolas_upshifts" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2808033) /Source="Nicolas_upshifts" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2808035..2808313) /Source="Nicolas_S_feature" /locus_tag="new_3388009_3388287_c" /HighExp="Etha, Gly, S2, Glucon, Pyr, G/S, S1, Lbstat, Cold, HiTm" /AntisenseName="yuxN" /AntisenseCor="-0.128326996122899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigH, SigA" /TUshortPSig="0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1272" promotor_-35 complement(2808053..2808060) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2808139..2809014 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391183.1" /db_xref="EnsemblGenomes-Gn:BSU33030" /db_xref="EnsemblGenomes-Tr:CAB15293" /db_xref="GOA:P40950" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG11072" /db_xref="UniProtKB/Swiss-Prot:P40950" /translation="MKEKEKLIIETALKLFAQKGYNSTSVQEIAKECKISKGAFYIYF PSKEALLLSMLNYYYDKTFTRILNIKTKGDSPRTAYRKQLTVLYENILEHKDFISMQL KEGSLPYTEEVEQCAKKIRQSSLQFHIDSLLNIYGKKAEPYTAELCFLIEGISQIYLE CMILLGYTVKPSQLADIIMNRIDDMVKGMSERNDKPFITLEEASSLFGPLTHGRPDPL TESIVKSLRDKINSLNTNSSLELSESLDILEAEMKKKTPKLAIIKGMIHNLTESEALA KDAEQLKYLLKQQHI*" /label="yuxN CDS" gene 2808139..2809014 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /label="yuxN gene" promotor_-10 complement(2808303..2808322) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2808313) /Source="Nicolas_upshifts" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2808315..2808856) /Source="Nicolas_S_feature" /locus_tag="new_3388289_3388830_c" /HighExp="LBGstat, Cold, S2, Glucon, S1, Pyr, G/S, C30, GM 10, GM-0.1" /AntisenseName="yuxN" /AntisenseCor="-0.341746670828522" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigH, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1273" promotor_-35 complement(2808336..2808343) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2808848..2808866) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2808856) /Source="Nicolas_upshifts" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2808858..2808987) /Source="Nicolas_S_feature" /locus_tag="new_3388832_3388961_c" /HighExp="S2, S1, G/S, Glucon, Pyr, T3.30H, M9-stat, BT, Cold, T4.0H" /AntisenseName="yuxN" /AntisenseCor="-0.30886083736579201" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1274" promotor_-35 complement(2808879..2808886) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2808989 /Source="Nicolas_upshifts" /id="D1707" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="3.14099" /MaxDrop="3.7614" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2589" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" downshifts complement(2809032) /Source="Nicolas_upshifts" /id="D1708" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="5.30537" /MaxDrop="3.29426" /score="-2.73895091" /energy="-13.6" /TU="U2593,U2594" /idTUdmin="U2591" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(2809050..2810438) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /EC_number="4.2.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:2509422, 3130545, 3923430, 9647666, 22914898, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509422, 3130545, 3923430, 9647666, 22914898, 28032445; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fumarate hydratase" /protein_id="NP_391184.1" /db_xref="EnsemblGenomes-Gn:BSU33040" /db_xref="EnsemblGenomes-Tr:CAB15294" /db_xref="GOA:P07343" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR005677" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10384" /db_xref="UniProtKB/Swiss-Prot:P07343" /translation="MEYRIERDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPMRVV KAFAILKRSTALANKRLGNLDAEKAEAIAAVCDDVLKGKYDDNFPLVVWQTGSGTQSN MNMNEVVANRATALLKEKNSDQTIHPNDDVNRSQSSNDTFPTAMHVAAVLAVYEQLVP ALDQLRNTLDEKAKAYNDIVKIGRTHLQDATPLTLGQEISGWVHMLDRSKEMILEATD KMRALAIGGTAVGTGINAHPEFGELVSEEITKLTGQTFSSSPNKFHALTSHDEITYAH GALKALAADLMKIANDVRWLASGPRCGIGEIVIPENEPGSSIMPGKVNPTQSEALTMI AAQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLSDGMNSFHDKCAVGIEPN KETIQENLSNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLELLTEEQFNE MVKPEDMVKPKA*" /label="fumC CDS" gene complement(2809050..2810438) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /label="fumC gene" upshifts complement(2810462) /Source="Nicolas_upshifts" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2810467..2810485) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2810496..2810504) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2810505..2810690) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097786.1" /db_xref="EnsemblGenomes-Gn:BSU33049" /db_xref="EnsemblGenomes-Tr:CAX52692" /db_xref="InterPro:IPR025088" /db_xref="UniProtKB/Swiss-Prot:C0H3R3" /translation="MAQVRLAGKQEEIEQLIRSFEQHYDVSYTSKEYGRTNPKYKYSK DSRVYLELKLKSAKIEK*" /label="yvzF CDS" gene complement(2810505..2810690) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /label="yvzF gene" downshifts 2810694 /Source="Nicolas_upshifts" /id="D1709" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="1.13377" /MaxDrop="4.4478" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2595" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2810734..2810753) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2810743..2810749 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2810748) /Source="Nicolas_upshifts" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2810763..2810774 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2810766 /Source="Nicolas_upshifts" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2810769..2810772) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2810808..2812256 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the GerA germination receptor" /protein_id="NP_391185.2" /db_xref="EnsemblGenomes-Gn:BSU33050" /db_xref="EnsemblGenomes-Tr:CAB15295" /db_xref="GOA:P07868" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10385" /db_xref="UniProtKB/Swiss-Prot:P07868" /translation="MEQTEFKEYIHDNLALVLPKLKENDDLVKNKKMLANGLVFYYLY FSEMTDENKVSEAIKTLIKDEETLTLDQVKKRLDQLDARPVETAKKTIESILNGNCAV FINGLDKAYILTTGKKKTRSLTEPTTEKVVRGPKVAFVEDIDTNLALIRQRTSHPKLI TKKIMIGENKLKPAAIMYIEGKAKKSVIKEVKARLKNIQLEDIQDSGTLEELIEDNKY SPFPQIQNTERPDKVSSALFNGRVAILVDSSPFVLLVPVSLGILMQSPDDYYERWISA SLIRSLRFASIFITLFLSSIYITLVSFHQGLLPTALAVTISANRENVPFPPIFEALLM EVTIELLREAGLRLPNPLGQTIGLVGGVVIGQAAVEANLVSSILVIVVSVIALASFTV PQYGMGLSFRVLRFISMFSAAILGLYGIILFMLVVYTHLTRQTSFGSPYFSPNGFFSL KNTDDSIIRLPIKNKPKEVNNPNEPKTDSTET*" /label="gerAA CDS" gene 2810808..2812256 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /label="gerAA gene" S_feature complement(2811804..2814447) /Source="Nicolas_S_feature" /locus_tag="new_3391778_3394421_c" /HighExp="Cold, H2O2, G135, G180, Paraq, G150, Oxctl, T-5.40H, LBGstat, T-4.40H" /AntisenseName="gerAC" /AntisenseCor="-9.7163861003102397E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1275" CDS 2812225..2813322 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16740944, 16850406, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16740944, 16850406, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA; putative transporter" /protein_id="NP_391186.1" /db_xref="EnsemblGenomes-Gn:BSU33060" /db_xref="EnsemblGenomes-Tr:CAB15296" /db_xref="GOA:P07869" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10386" /db_xref="UniProtKB/Swiss-Prot:P07869" /translation="MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDG WITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVA SFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIIL LIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTF RYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFL LVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMY SDYLGYIFVSLFLLPFILFFIVALKRRITTK*" /label="gerAB CDS" gene 2812225..2813322 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /label="gerAB gene" CDS 2813319..2814440 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA" /protein_id="NP_391187.1" /db_xref="EnsemblGenomes-Gn:BSU33070" /db_xref="EnsemblGenomes-Tr:CAB15297" /db_xref="GOA:P07870" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG10387" /db_xref="UniProtKB/Swiss-Prot:P07870" /translation="MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLE LTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSK SVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTEN NKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPI EVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRL SEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHY PQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK*" /label="gerAC CDS" gene 2813319..2814440 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /label="gerAC gene" CDS complement(2814448..2815083) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvqE] responding to cell wall stress" /protein_id="NP_391188.1" /db_xref="EnsemblGenomes-Gn:BSU33080" /db_xref="EnsemblGenomes-Tr:CAB15298" /db_xref="GOA:O32197" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14133" /db_xref="UniProtKB/Swiss-Prot:O32197" /translation="MIRVLLIDDHEMVRMGLAAFLEAQPDIEVIGEASDGSEGVRLAV ELSPDVILMDLVMEGMDGIEATKQICRELSDPKIIVLTSFIDDDKVYPVIEAGALSYL LKTSKAAEIADAIRAASKGEPKLESKVAGKVLSRLRHSGENALPHESLTKRELEILCL IAEGKTNKEIGEELFITIKTVKTHITNILSKLDVSDRTQAAVYAHRNHLVN*" /label="liaR CDS" gene complement(2814448..2815083) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /label="liaR gene" CDS complement(2815061..2816143) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /function="16.12: Sense" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LiaR(YvqC)] sensing cell wall stress" /protein_id="NP_391189.1" /db_xref="EnsemblGenomes-Gn:BSU33090" /db_xref="EnsemblGenomes-Tr:CAB15299" /db_xref="GOA:O32198" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR017202" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14134" /db_xref="UniProtKB/Swiss-Prot:O32198" /translation="MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLL SSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPL GDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHD AVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLE GKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKAS KVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGK GTQIEVKVPIFPEEKGENERDSSIID*" /label="liaS CDS" gene complement(2815061..2816143) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /label="liaS gene" CDS complement(2816140..2816865) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane component associated to the LiaRS two-component system" /protein_id="NP_391190.1" /db_xref="EnsemblGenomes-Gn:BSU33100" /db_xref="EnsemblGenomes-Tr:CAB15300" /db_xref="GOA:O32199" /db_xref="InterPro:IPR016975" /db_xref="InterPro:IPR024425" /db_xref="SubtiList:BG14135" /db_xref="UniProtKB/Swiss-Prot:O32199" /translation="MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKK YSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQ VNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMI PEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDF SESKRRVKVSVSLFIGDVDVKYV*" /label="liaF CDS" gene complement(2816140..2816865) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /label="liaF gene" CDS complement(2816899..2817771) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="sensor of antibiotic stress on the cell wall" /protein_id="NP_391191.2" /db_xref="EnsemblGenomes-Gn:BSU33110" /db_xref="EnsemblGenomes-Tr:CAB15301" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14136" /db_xref="UniProtKB/Swiss-Prot:O32200" /translation="MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASAS PRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFL NGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRI QDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTG PVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRH PIDIKTDSGDLAIR*" /label="liaG CDS" gene complement(2816899..2817771) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /label="liaG gene" promotor_-10 complement(2817790..2817809) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2817810) /Source="Nicolas_upshifts" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2817824..2817827) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2817872..2818549) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23874669, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23874669, 24666271, 28546427; Product type f: factor" /codon_start=1 /transl_table=11 /product="modulator of liaIHGFSR (yvqIHGFEC) operon expression" /protein_id="NP_391192.1" /db_xref="EnsemblGenomes-Gn:BSU33120" /db_xref="EnsemblGenomes-Tr:CAB15302" /db_xref="GOA:O32201" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG14137" /db_xref="UniProtKB/Swiss-Prot:O32201" /translation="MVLKRIRDMFVASVHEGLDKMENPKVMLNQYVRDMESDIAKAKQ TIVKQHTIAYQFKKKYEEAAEVAGKRKNQAQLAFDAGEEELAKKALTEMKYLEGKAAE HKASYEQANSQLADLKEQLAALETKLQDVKDKKQALIARANAAKAKEHMNTTFDKIDS ESAYREFLRIENRIEEMEIRANYSKSAEAGTELTRKEFADDVEAEIEKMRTLSLQKSD QTKAANE*" /label="liaH CDS" gene complement(2817872..2818549) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /label="liaH gene" downshifts complement(2817888) /Source="Nicolas_upshifts" /id="D1710" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="3.84852" /MaxDrop="3.1352" /score="-8.3477012" /energy="-4.5" /TU="U2597" /idTUdmin="U2598" /TUdmin=1243 /isTUend="FALSE" /label="downshifts" CDS complement(2818576..2818956) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427; Product type s: structure" /codon_start=1 /transl_table=11 /product="membrane anchor for the phage-shock protein A homolog LiaH" /protein_id="NP_391193.1" /db_xref="EnsemblGenomes-Gn:BSU33130" /db_xref="EnsemblGenomes-Tr:CAB15303" /db_xref="GOA:O32202" /db_xref="SubtiList:BG14138" /db_xref="UniProtKB/Swiss-Prot:O32202" /translation="MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGI KRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSF DPEPASAAYQSHFDDEWEEFLKKK*" /label="liaI CDS" gene complement(2818576..2818956) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /label="liaI gene" promotor_-10 complement(2818979..2818998) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2818999) /Source="Nicolas_upshifts" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2819013..2819016) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2819118..2820386) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15273097, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux protein" /protein_id="NP_391194.1" /db_xref="EnsemblGenomes-Gn:BSU33140" /db_xref="EnsemblGenomes-Tr:CAB15304" /db_xref="GOA:O32203" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14139" /db_xref="UniProtKB/Swiss-Prot:O32203" /translation="MVNLIESDSIWKRNFNYLFFSRIVKISGDMFAFNSILWFLIYDG KGAIGTALLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAG FSPLWFVMTLMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVT LCGAFLTFISPSYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKR GFRLVRKHQILYPLAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGA FLLGFVLAKVKVNRYGLLFVTAGIIEGFAFFITGMNTFLPLVFFAAFTFGAAVSAVNV PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEI IAGIGILLFTKLAKAERSDLIKEREASVHL*" /label="yvqJ CDS" gene complement(2819118..2820386) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /label="yvqJ gene" downshifts complement(2819131) /Source="Nicolas_upshifts" /id="D1711" /incds=0 /nref=78 /ntot=164 /MaxReadThrough="0.70612" /MaxDrop="4.80625" /score="32.7496145" /energy="-12.9" /TU="NA" /idTUdmin="U2598" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2820420..2820439) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2820431) /Source="Nicolas_upshifts" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2820454..2820461) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2820557) /Source="Nicolas_upshifts" /id="D1712" /incds=0 /nref=33 /ntot=211 /MaxReadThrough="1.54601" /MaxDrop="4.92923" /score="51.1311697" /energy="-17.1" /TU="NA" /idTUdmin="U2599" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2820563..2821144) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /EC_number="2.5.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12869542, 14704351, 17588214, 19933577, 21514283; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP:cob(I)alamin adenosyltransferase" /protein_id="NP_391195.2" /db_xref="EnsemblGenomes-Gn:BSU33150" /db_xref="EnsemblGenomes-Tr:CAB15305" /db_xref="GOA:O34899" /db_xref="InterPro:IPR016030" /db_xref="InterPro:IPR029499" /db_xref="InterPro:IPR036451" /db_xref="PDB:1RTY" /db_xref="SubtiList:BG14140" /db_xref="UniProtKB/Swiss-Prot:O34899" /translation="MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLAL AELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTA EAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYF FAAARVVNARSGIGDVEYERSAIVFRDRNSSES*" /label="yvqK CDS" gene complement(2820563..2821144) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /label="yvqK gene" CDS complement(2821167..2822495) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 transport system, ATPase component" /protein_id="NP_391196.1" /db_xref="EnsemblGenomes-Gn:BSU33160" /db_xref="EnsemblGenomes-Tr:CAB15306" /db_xref="GOA:O34631" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14141" /db_xref="UniProtKB/Swiss-Prot:O34631" /translation="MKAEGLSGGYGDSRLINNVSLTVEKGEFLGILGPNGSGKTTLLH LLTGTLPAKKGRVYLAGKLLADYKPKELAQIMAVLPQKMDQAFTFTVEETVAFGRYPF QTGLFRQQTEKGEAIVQEAMEQTGVADFAQKPIRELSGGEQQRVYLAQALAQQPRILF LDEPTNFLDLAYQKDLLDLIKRLTRESGLAAVSVFHDLNTASLYCDGLMFMKNGTAGP KQKPEYAVTEQSIKAVYDTDVTALVHQSSPKPMIVIQPEKDSVKRQSIPFEALLQAGR DDILLQTEIPLRTLSSTPIGAGFSWSRTLIHKRLPDQPDPIEGLTACLSESGFQLQET CAMASSERLDRFVYRTYEDGELSVFICVQTGFSIWILINGYAADQFFIKALMAAEAER TKVLGDGGGTGDILIAATQTQQSENIEQRLNQLIKKGTAECIKEAAELFE*" /label="yvrA CDS" gene complement(2821167..2822495) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /label="yvrA gene" CDS complement(2822495..2823556) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 15849754, 16850406, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 permease" /protein_id="NP_391197.1" /db_xref="EnsemblGenomes-Gn:BSU33170" /db_xref="EnsemblGenomes-Tr:CAB15307" /db_xref="GOA:O34451" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG14142" /db_xref="UniProtKB/Swiss-Prot:O34451" /translation="MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPA VFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPL ADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHA SMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPF FLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIG FVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLA GAPVFALILIRQHRGGRSL*" /label="yvrB CDS" gene complement(2822495..2823556) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /label="yvrB gene" CDS complement(2823519..2824463) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative lipoprotein binding vitamin B12" /protein_id="NP_391198.1" /db_xref="EnsemblGenomes-Gn:BSU33180" /db_xref="EnsemblGenomes-Tr:CAB15308" /db_xref="GOA:O34805" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG14143" /db_xref="UniProtKB/Swiss-Prot:O34805" /translation="MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTID DASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDM NVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMI GEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFM NEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAV KHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE*" /label="yvrC CDS" gene complement(2823519..2824463) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /label="yvrC gene" S_feature complement(2824464..2824733) /Source="Nicolas_S_feature" /locus_tag="new_3404438_3404707_c" /HighExp="LBGtran, LBGexp, Etha, LPh, S3, Lbexp, G180, dia0, HPh, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.956, 1" /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1276" misc_RNA complement(2824572..2824702) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /product="putative coenzyme B12 (AdoCbl) riboswitch" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 17038623, 21140903, 25917914; Product type n: RNA" /function="16.3: Control" /label="srbL RNA" gene complement(2824572..2824702) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /label="srbL gene" promotor_-10 complement(2824710..2824729) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2824733) /Source="Nicolas_upshifts" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2824735..2825662) /Source="Nicolas_S_feature" /locus_tag="new_3404709_3405636_c" /HighExp="Etha, B60, Sw, M9-stat, B36, C30, C90, Salt, G135, Gly" /AntisenseName="yvrD" /AntisenseCor="1.5286196477289399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1277" promotor_-35 complement(2824745..2824752) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2824795..2824802 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2824817..2824836 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2824821 /Source="Nicolas_upshifts" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="upshifts" CDS 2824861..2825652 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9922248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391199.1" /db_xref="EnsemblGenomes-Gn:BSU33190" /db_xref="EnsemblGenomes-Tr:CAB15309" /db_xref="GOA:O34782" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14144" /db_xref="UniProtKB/Swiss-Prot:O34782" /translation="MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETV DRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVT DEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTA LISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVN EPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL*" /label="yvrD CDS" gene 2824861..2825652 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /label="yvrD gene" downshifts 2825523 /Source="Nicolas_upshifts" /id="D1713" /incds=1 /nref=2 /ntot=89 /MaxReadThrough="6.202" /MaxDrop="3.35017" /score="36.8938178" /energy="-12" /TU="U2600" /idTUdmin="U2600" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 2825633 /Source="Nicolas_upshifts" /id="D1714" /incds=0 /nref=105 /ntot=218 /MaxReadThrough="2.44739" /MaxDrop="6.33457" /score="36.8938178" /energy="-12" /TU="NA" /idTUdmin="U2600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2825690..2826568) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar lactone lactonase" /protein_id="NP_391200.1" /db_xref="EnsemblGenomes-Gn:BSU33200" /db_xref="EnsemblGenomes-Tr:CAB15310" /db_xref="GOA:O34940" /db_xref="InterPro:IPR005511" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013658" /db_xref="SubtiList:BG14145" /db_xref="UniProtKB/Swiss-Prot:O34940" /translation="MDAVLEADTRAVIGEGPLWDEENGRLYWVDILGSELHIFDPEEK INRSIKFKSFVTALAKYSKDELIMTMKDGFYLYHLRDDSLEKIKQPKDMHESLRFNDA KCDPYGRLWAGTTSMEGEQKQASLYRLNLDGSLVKIKDQVSTSNGLDWDRERNLMYYI DTPTQEIVRYSYDPQSGDVSNPEPVYRFDQSDGLPDGMTIDQNGMLWVALFGGSRVVH IDPFQKKEINSISVPAKYVTCCAFGGRDLKTLYITTATEQMTEKERYEQPHAGGLFSA QLETGGYQPVPFAGDV*" /label="yvrE CDS" gene complement(2825690..2826568) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /label="yvrE gene" downshifts complement(2825707) /Source="Nicolas_upshifts" /id="D1715" /incds=0 /nref=31 /ntot=260 /MaxReadThrough="7.17016" /MaxDrop="5.74101" /score="29.8014794" /energy="-12" /TU="U2601" /idTUdmin="U2602" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2826592..2826610) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2826611) /Source="Nicolas_upshifts" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2826624..2826630) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2826640..2828382) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrH)]" /protein_id="NP_391201.2" /db_xref="EnsemblGenomes-Gn:BSU33210" /db_xref="EnsemblGenomes-Tr:CAB15311" /db_xref="GOA:O34989" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14146" /db_xref="UniProtKB/Swiss-Prot:O34989" /translation="MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNS GLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDV PGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQK IDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPW NYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWM TVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFE SMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPE EVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNP FSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHIS LKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSR TNIGTVITILFKKQ*" /label="yvrG CDS" gene complement(2826640..2828382) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /label="yvrG gene" CDS complement(2828379..2829092) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrG)]" /protein_id="NP_391202.2" /db_xref="EnsemblGenomes-Gn:BSU33221" /db_xref="EnsemblGenomes-Tr:CAB15312" /db_xref="GOA:P94504" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12452" /db_xref="UniProtKB/Swiss-Prot:P94504" /translation="MENASILIVDDEKAIVDMIKRVLEKEGYRNILDAASAEEAIPVV KANKVDLIVLDVMMGGMSGFEACTLIREYSDAPIFFLTARSSDADKLSGFAVGADDYI TKPFNPLELAARIRAHLKRTYQSKETSSNQTYTYDYFTFSPQNAELIVGGEAVACSAQ LLQLLQYFCEHPNVVLSKDQIYEKVWGYPSYGDNNTVMVHIRKLREKIERDPSNPEYI VTVRGLGYRFIPNPEGKRS*" /label="yvrH CDS" gene complement(2828379..2829092) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /label="yvrH gene" misc_feature complement(2829123..2829142) /Source="Nicolas_upshift_promotors" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2829141) /Source="Nicolas_upshifts" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="upshifts" CDS complement(2829245..2829484) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sigma-O" /protein_id="YP_003097787.1" /db_xref="EnsemblGenomes-Gn:BSU33222" /db_xref="EnsemblGenomes-Tr:CAX52693" /db_xref="GOA:C0H3R4" /db_xref="UniProtKB/Swiss-Prot:C0H3R4" /translation="MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDL EQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS*" /label="rsoA CDS" gene complement(2829245..2829484) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /label="rsoA gene" downshifts complement(2829252) /Source="Nicolas_upshifts" /id="D1716" /incds=0 /nref=4 /ntot=30 /MaxReadThrough="2.45068" /MaxDrop="3.82244" /score="12.6471586" /energy="-8.2" /TU="NA" /idTUdmin="U2605" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2829480..2829498) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2829488..2830018) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16306698, 18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16306698, 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="alternative sigma factor" /protein_id="NP_391203.2" /db_xref="EnsemblGenomes-Gn:BSU33230" /db_xref="EnsemblGenomes-Tr:CAB15313" /db_xref="GOA:O34843" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14147" /db_xref="UniProtKB/Swiss-Prot:O34843" /translation="MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKE IRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQ DDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKG LENIRKQLAAQKKGEK*" /label="sigO CDS" gene complement(2829488..2830018) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /label="sigO gene" upshifts complement(2829489) /Source="Nicolas_upshifts" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2829513..2829519) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2830021..2830040) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2830028) /Source="Nicolas_upshifts" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" CDS 2830033..2830371 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in oxalate decarboxylase expression" /protein_id="YP_003097788.1" /db_xref="EnsemblGenomes-Gn:BSU33239" /db_xref="EnsemblGenomes-Tr:CAX52694" /db_xref="InterPro:IPR024419" /db_xref="UniProtKB/Swiss-Prot:C0H3R5" /translation="MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFY RFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIEL MTELKDHAKK*" /label="yvrJ CDS" gene 2830033..2830371 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /label="yvrJ gene" promotor_-35 complement(2830055..2830062) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2830071..2830090) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2830083) /Source="Nicolas_upshifts" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2830105..2830111) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2830117..2830217 /Source="Nicolas_upshift_promotors" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="promotor_no_box" upshifts 2830177 /Source="Nicolas_upshifts" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="upshifts" promotor_no_box 2830345..2830445 /Source="Nicolas_upshift_promotors" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2830405..2830491 /Source="Nicolas_S_feature" /locus_tag="new_3410379_3410465" /HighExp="T5.0H, T4.0H, T3.30H, Lbstat, T3.0H, nit, T2.0H, T2.30H, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.317" /TUlongSig="Sig-" /TUlongPSig="0.278" /label="S1278" upshifts 2830405 /Source="Nicolas_upshifts" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="upshifts" CDS 2830492..2831649 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase" /protein_id="NP_391204.1" /db_xref="EnsemblGenomes-Gn:BSU33240" /db_xref="EnsemblGenomes-Tr:CAB15314" /db_xref="GOA:O34714" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="PDB:1J58" /db_xref="PDB:1L3J" /db_xref="PDB:1UW8" /db_xref="PDB:2UY8" /db_xref="PDB:2UY9" /db_xref="PDB:2UYA" /db_xref="PDB:2UYB" /db_xref="PDB:2V09" /db_xref="PDB:3S0M" /db_xref="PDB:4MET" /db_xref="PDB:5HI0" /db_xref="SubtiList:BG14148" /db_xref="UniProtKB/Swiss-Prot:O34714" /translation="MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGT VSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEW AYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSF SENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGP NGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHP NTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEI FKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKKCSK*" /label="oxdC CDS" gene 2830492..2831649 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /label="oxdC gene" downshifts 2831635 /Source="Nicolas_upshifts" /id="D1717" /incds=0 /nref=11 /ntot=87 /MaxReadThrough="4.83038" /MaxDrop="4.39135" /score="2.61432951" /energy="-9.4" /TU="U2607" /idTUdmin="U2607" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 2831710..2832120 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18573182, 19047353, 26651345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18573182, 19047353, 26651345; Product type f: factor" /codon_start=1 /transl_table=11 /product="acid stress-sensitive anti sigma factor" /protein_id="NP_391205.1" /db_xref="EnsemblGenomes-Gn:BSU33250" /db_xref="EnsemblGenomes-Tr:CAB15315" /db_xref="GOA:O34686" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14149" /db_xref="UniProtKB/Swiss-Prot:O34686" /translation="MKHQNPSKRLLRLSIKYLLAAAAVVLTYFAVIYILFSLAGTSYR SAAHVLLFAVVFLVLGLCFEPFERLMIHSFTFFKTGKRLFILLAGIVQLLFLWMTAHT TDQLISDIWLSTTEEMIVAAVFLILDKCNSALPS*" /label="rsiO CDS" gene 2831710..2832120 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /label="rsiO gene" downshifts 2832119 /Source="Nicolas_upshifts" /id="D1718" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.57216" /MaxDrop="3.72691" /score="-9.50136752" /energy="-7.4" /TU="NA" /idTUdmin="U2607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2832154..2833383) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391207.3" /db_xref="EnsemblGenomes-Gn:BSU33260" /db_xref="EnsemblGenomes-Tr:CAB15317" /db_xref="GOA:P46324" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG11368" /db_xref="UniProtKB/Swiss-Prot:P46324" /translation="MLEHIRISFQSIFSHKLRSILTMLGVIIGIAAIIAIVSMLKGQS EQLKQSMIGMGNNAINVVYQPSGGEEESGGPQVSYASAPPVAEETVKAIKSDPMVKGL SLYYLSEGASVFHLTNVSYPQVYGVDDDYFDMFPIRITEGRKLTENDLNSTHQVVMIN EAVRDELFPDGEALHKSIEMNGVPFKVVGVFKEKNQQESMFEGDYANPVLYVPKKVWP LIEGFDAPTQIAVQADSSEHIQEAGVMAADLLNQGLSEAELEKAEYSVMDLQEIAQEV ESFNQSFALLLGGIASISLLVGGIGVMNIMLVSVTERTREIGIKKALGAKRRVILFQF LTEAVVLTSIGGILGVLAGFGIAKLLTVIFPMPFIVSIPAVVGALIFSMAVGIIFGLL PSIKASKLQPVDALRYE*" /label="yvrN CDS" gene complement(2832154..2833383) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /label="yvrN gene" downshifts complement(2832171) /Source="Nicolas_upshifts" /id="D1719" /incds=0 /nref=10 /ntot=218 /MaxReadThrough="2.36812" /MaxDrop="4.29282" /score="13.74435" /energy="-11.3" /TU="NA" /idTUdmin="U2608" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2833376..2834065) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544226, 22517742; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391208.2" /db_xref="EnsemblGenomes-Gn:BSU33270" /db_xref="EnsemblGenomes-Tr:CAB15318" /db_xref="GOA:O34979" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14151" /db_xref="UniProtKB/Swiss-Prot:O34979" /translation="MLTLNNISKSYKLGKEEVPILKHINLTVQAGEFLAIMGPSGSGK STLMNIIGCLDRPTSGTYTLDQIDILKGKDGALAEIRNESIGFVFQTFHLLPRLTALQ NVELPMIYNKVKKKERRQRAYEALEKVGLKDRVSYKPPKLSGGQKQRVAIARALVNQP RFILADEPTGALDTKSSEQILALFSELHREGKTIIMITHDPDVAKKADRTVFIRDGEL VLDERGDISHA*" /label="yvrO CDS" gene complement(2833376..2834065) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /label="yvrO gene" CDS complement(2834049..2835242) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter membrane fusion component" /protein_id="NP_391209.1" /db_xref="EnsemblGenomes-Gn:BSU33280" /db_xref="EnsemblGenomes-Tr:CAB15319" /db_xref="GOA:O35007" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG14152" /db_xref="UniProtKB/Swiss-Prot:O35007" /translation="MSKKKKWLIGGAICAGVLVLAGIGAGGFYFFTHMNQVAVSSEPY AESVAVYMGGDSESGQTFSGKVEPEKQQKVYIDSEKGSIKKTYVKEGDQVKKGDKLFE YEGEDHSDEVEQANLQIEMTNLQINRLQKSITETEKKLKVAGKEEKNQLQDELDQTNF DLKTSQLELKQHQKELAGLTKNKGSNVITSKHDGIVQSVNQDIADGATGDQAAGPYIQ IVSTGKYLVKSQINELLMDTIKKGSKVRVTLKTGGEGEWKGKVTSIGKLPAGAGEGEE SESFADEEMNPQSSNYPFTILLDSHKGLEVGYHVNIEVMSDNADADTIKLPSDMVIQD DGEPYVWKADENHKAVKQPVEIGETDENDMVEIKSGLTPEDYVIYPDPAVKEGKQVTV NADTE*" /label="yvrP CDS" gene complement(2834049..2835242) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /label="yvrP gene" promotor_-10 complement(2835286..2835305) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2835299) /Source="Nicolas_upshifts" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2835320..2835327) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2835413..2836222) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ATP-binding protein)" /protein_id="NP_391210.1" /db_xref="EnsemblGenomes-Gn:BSU33290" /db_xref="EnsemblGenomes-Tr:CAB15335" /db_xref="GOA:P49938" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11390" /db_xref="UniProtKB/Swiss-Prot:P49938" /translation="MNSLSTEQLGIGYGDRVIVEDLNISIPKGKITTLIGPNGCGKST ILKTMSRIMRSHAGAVYLNGKAIHKMSTKDIAKDMAILPQTPEAPSGLTVHELVSYGR FPHQSGFGRLNDEDRRIIKWALEETGMAEYAERPIEALSGGQRQRVWIAMALAQGTEL LLLDEPTTYLDLAHQLEILQLLDRLNKEQGRTILMVIHDLNHAARFSHYMIALKKGTV IKEGTALEVMTPDILKQVFQIDAEIVTDPRTNKPVCLTYDLIKNEKELVTV*" /label="fhuC CDS" gene complement(2835413..2836222) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /label="fhuC gene" downshifts complement(2835430) /Source="Nicolas_upshifts" /id="D1720" /incds=0 /nref=190 /ntot=245 /MaxReadThrough="1.31294" /MaxDrop="6.48454" /score="40.5986253" /energy="-11" /TU="NA" /idTUdmin="U2610" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2835569..2835578 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2835591..2835610 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2835595 /Source="Nicolas_upshifts" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2836238..2837248) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251, 15849754, 16850406, 24362930; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391211.1" /db_xref="EnsemblGenomes-Gn:BSU33300" /db_xref="EnsemblGenomes-Tr:CAB15336" /db_xref="GOA:P49937" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11391" /db_xref="UniProtKB/Swiss-Prot:P49937" /translation="MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFF GQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSL AVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGI GVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYK ARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVAR RLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMK AN*" /label="fhuG CDS" gene complement(2836238..2837248) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /label="fhuG gene" CDS complement(2837248..2838402) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 15849754, 16850406, 24362930; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391212.1" /db_xref="EnsemblGenomes-Gn:BSU33310" /db_xref="EnsemblGenomes-Tr:CAB15337" /db_xref="GOA:P49936" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11389" /db_xref="UniProtKB/Swiss-Prot:P49936" /translation="MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIR TASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKT SHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGIST AIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDL AKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPC SAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL*" /label="fhuB CDS" gene complement(2837248..2838402) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /label="fhuB gene" promotor_-10 complement(2838335..2838354) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2838352) /Source="Nicolas_upshifts" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2838366..2838373) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2838414..2838421 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2838436..2838455 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2838445 /Source="Nicolas_upshifts" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2838500..2839447 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 26919525; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ferrichrome-bindinglipoprotein)" /protein_id="NP_391213.1" /db_xref="EnsemblGenomes-Gn:BSU33320" /db_xref="EnsemblGenomes-Tr:CAB15338" /db_xref="GOA:P37580" /db_xref="InterPro:IPR002491" /db_xref="PDB:3G9Q" /db_xref="PDB:3HXP" /db_xref="SubtiList:BG10828" /db_xref="UniProtKB/Swiss-Prot:P37580" /translation="MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFT YKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENI GDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTG TEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYK DLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWK NLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK*" /label="fhuD CDS" gene 2838500..2839447 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /label="fhuD gene" downshifts 2839423 /Source="Nicolas_upshifts" /id="D1721" /incds=0 /nref=168 /ntot=245 /MaxReadThrough="3.82329" /MaxDrop="5.73183" /score="11.0136807" /energy="-12.1" /TU="U2611" /idTUdmin="U2611" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 2839467 /Source="Nicolas_upshifts" /id="D1722" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="3.01143" /MaxDrop="4.08479" /score="11.0136807" /energy="-12.1" /TU="NA" /idTUdmin="U2611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2839621 /Source="Nicolas_upshifts" /id="D1723" /incds=0 /nref=8 /ntot=87 /MaxReadThrough="0.219110000000001" /MaxDrop="3.67928" /score="7.53231618" /energy="-13.7" /TU="NA" /idTUdmin="U2611" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(2839682..2841091) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14627808, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lysine permease" /protein_id="NP_391214.1" /db_xref="EnsemblGenomes-Gn:BSU33330" /db_xref="EnsemblGenomes-Tr:CAB15339" /db_xref="GOA:O32204" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG14154" /db_xref="UniProtKB/Swiss-Prot:O32204" /translation="MEQTKKWGFWLLTAFVVGNMVGSGIFSLPSSLASIASPFGATSA WLLTGAGVLMIALVFGHLSIRKPELTAGPQSYARALFSDPKKGNAAGFTMVWGYWVAS WISNVAIITSLAGYLTSFFPILVDKREMFSIGGQEVTLGQLLTFAVCTILLWGTHAIL VASINGASKLNFVTTLSKVLGFVFFIVAGLFVFQTSLFGHFYFPVQGENGTSIGIGGQ VHNAAISTLWAFVGIESAVILSGRARSQRDVKRATITGLLIALSIYIIVTLITMGVLP HDKLVGSEKPFVDVLYAIVGNAGSVIMALLAILCLFGTMLGWILLGSEVPYQAAKAGD FPAFFAKTNKKGSPVIALIITNVMSQVFIFSVISRTISDAFTFLTTAATLAYLIPYLV SAIYSLKVVIKGETYDQLKGSRVRDGLIAILACAYSVFVIVTGTADLTTFILGIGLFF VGLIVYPFVSNKFQKEKQA*" /label="lysP CDS" gene complement(2839682..2841091) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /label="lysP gene" downshifts complement(2839697) /Source="Nicolas_upshifts" /id="D1724" /incds=0 /nref=168 /ntot=213 /MaxReadThrough="0.441040000000001" /MaxDrop="6.03347" /score="23.064706" /energy="-13.7" /TU="NA" /idTUdmin="U2613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2840509..2840513 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2840531..2840547 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2840538 /Source="Nicolas_upshifts" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="upshifts" S_feature 2840545..2841512 /Source="Nicolas_S_feature" /locus_tag="new_3420519_3421486" /HighExp="S3, S4, S7, S5, S8, S6, Etha, M9-stat, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="7.6401427420847101E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.4" /TUlongSig="NA" /TUlongPSig="NA" /label="S1279" downshifts complement(2841193) /Source="Nicolas_upshifts" /id="D1725" /incds=0 /nref=1 /ntot=43 /MaxReadThrough="5.98281" /MaxDrop="3.61093" /score="-2.14086757" /energy="-5" /TU="U2613,U2614" /idTUdmin="U2614" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" misc_RNA complement(2841195..2841374) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22416067; Product type n: RNA" /label="kswB RNA" gene complement(2841195..2841374) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /label="kswB gene" promotor_-10 complement(2841404..2841421) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2841415) /Source="Nicolas_upshifts" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2841436..2841443) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2841469 /Source="Nicolas_upshifts" /id="D1726" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.6441" /MaxDrop="3.53891" /score="-0.527038766" /energy="-4.8" /TU="U2612" /idTUdmin="U2612" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(2841491..2841631) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054593.1" /db_xref="EnsemblGenomes-Gn:BSU33340" /db_xref="EnsemblGenomes-Tr:CAE01467" /db_xref="GOA:Q7WY58" /db_xref="InterPro:IPR014220" /db_xref="SubtiList:BG14174" /db_xref="UniProtKB/Swiss-Prot:Q7WY58" /translation="MGFFNKDKGKRSEKEKNVIQGALEDAGSALKDDPLQEAVQKKKN NR*" /label="sspJ CDS" gene complement(2841491..2841631) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /label="sspJ gene" downshifts complement(2841501) /Source="Nicolas_upshifts" /id="D1727" /incds=0 /nref=40 /ntot=87 /MaxReadThrough="4.06523" /MaxDrop="5.5784" /score="-1.94521013" /energy="-14.5" /TU="U2614" /idTUdmin="U2614" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" upshifts complement(2841659) /Source="Nicolas_upshifts" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="upshifts" S_feature complement(2841661..2842249) /Source="Nicolas_S_feature" /locus_tag="new_3421635_3422223_c" /HighExp="S6, S8, S7, S5, BT, G135, Diami, G180, LBGstat, S4" /AntisenseName="yvsG" /AntisenseCor="0.46604658967097301" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1280" promotor_-10 complement(2841664..2841675) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-10" promotor_-35 complement(2841689..2841695) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-35" promotor_-35 2841721..2841728 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2841742 /Source="Nicolas_upshifts" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2841744..2841763 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2841798..2842280 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_391215.1" /db_xref="EnsemblGenomes-Gn:BSU33350" /db_xref="EnsemblGenomes-Tr:CAB15340" /db_xref="GOA:O32205" /db_xref="InterPro:IPR007404" /db_xref="InterPro:IPR016956" /db_xref="SubtiList:BG14153" /db_xref="UniProtKB/Swiss-Prot:O32205" /translation="MTGKTHIMGGIASCTAAAYYYGFDPVLMAASGAVGALIPDICHT QSKIGRKFPILSKVVSSVFGHRTFTHSLLFMLIMFFITSTYIPDKNISAGLMIGMASH LILDAWTVNGIKLLFPSTIRVRLPLYMKTGSFSEQLVLAGLTLASCYYFYMLFHGRMF *" /label="yvsG CDS" gene 2841798..2842280 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /label="yvsG gene" promotor_-35 2842294..2842301 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2842315..2842334 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2842327 /Source="Nicolas_upshifts" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2842380..2844233 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="primase of polyglycerolphosphate lipoteichoic acid (LTA) synthesis" /protein_id="NP_391216.1" /db_xref="EnsemblGenomes-Gn:BSU33360" /db_xref="EnsemblGenomes-Tr:CAB15341" /db_xref="GOA:O32206" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG14092" /db_xref="UniProtKB/Swiss-Prot:O32206" /translation="MKGTFFHNQRFLCFSILFMWIKTYVIYKLGFDLQIDTLLEELML LVNPLSFILPLFGIGLFLKENKQRAFLLIANLVLTVILISNTIFYGFYIDFITIPVLF QASNMSDMGSSVKELFHPLFIALFVDLVFLLLFARKTKHPQTKAAPHTIKRYYAASCG MLLCTLALAEVQQPKLLAHSFDREMLVKSIGLFQFHIYDTISQTVNISAKAFADEDSI TAIKNYTEADYSKPDQSKFGLAKGRNVIFVTLESTQSFVLNEKVNGKEITPFMNDLIK KSYSFDHFYQQTEQGKTSDSEFIVANSLYPSLSGAVFFTKSDHQFHTMYKSLKQHDYY SAVFHANHKTFWNRDVMYDTFGIDRFFDVDDFHVTPGTSTSWGLKDKEFLEQSAKKLK SLPQPFYSSFITLTNHFPFEIDEKDQLIDEFDSSSDLLNRYVTTVRYEDEALKHFIKK LKDEGLYENSMIVFMGDHYGISEAHNEAMAEFLGKDEITPYDNVQLQRVPFIIHIPGI TDQQPETIPDAGGQVDVRPTLMHLLGVETKGDIQFGNDLLSGDRTPFAVLRNGSFITN DYVYTKNTCYSQKTGEVLEDQDACLPYKEKANEELSLSDKILNGDLLRFSE*" /label="ltaSP CDS" gene 2842380..2844233 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /label="ltaSP gene" downshifts 2844219 /Source="Nicolas_upshifts" /id="D1728" /incds=0 /nref=30 /ntot=171 /MaxReadThrough="1.18268" /MaxDrop="3.6959" /score="21.1397957" /energy="-10.5" /TU="NA" /idTUdmin="U2615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2844261..2845187) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative molybdate binding regulator" /protein_id="NP_391217.1" /db_xref="EnsemblGenomes-Gn:BSU33370" /db_xref="EnsemblGenomes-Tr:CAB15342" /db_xref="GOA:O32207" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="InterPro:IPR024370" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14093" /db_xref="UniProtKB/Swiss-Prot:O32207" /translation="MNETSSYTIEEVAGLLKVSKLTVYDLIKKGVLPAYRVGRQMRVD EEDLKQYKTNMRMSQPIAAKEAPKQVQEAEPDGRPNVMISGQDISMDILSKHLENAIQ ETPLRKYKGSLNSLIDMYQGKCDIVSLHLYDAETGQYNAPYVKRILTGEPFCLINVVL RKAGLYVQKGNPKNIQGWKDLKRADIRIINREKGSGARVLLDEQLGLLGVNPADVVGY GDIVTDHYAAASQVSSGQADAGIGAQHAAHMGSVDFIPLIDEQYDIVVLKKNEQLLKA VKEILNSEDYKANLSHLNGYETKLTGKVILET*" /label="yvgK CDS" gene complement(2844261..2845187) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /label="yvgK gene" downshifts complement(2844273) /Source="Nicolas_upshifts" /id="D1729" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="0.15268" /MaxDrop="6.72558" /score="21.9965704" /energy="-10.5" /TU="NA" /idTUdmin="U2617" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2845199..2845218) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2845220) /Source="Nicolas_upshifts" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2845234..2845237) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2845256..2845275 /Source="Nicolas_upshift_promotors" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2845265 /Source="Nicolas_upshifts" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="upshifts" CDS 2845298..2846080 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9302996; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molybdate-binding lipoprotein" /protein_id="NP_391218.1" /db_xref="EnsemblGenomes-Gn:BSU33380" /db_xref="EnsemblGenomes-Tr:CAB15343" /db_xref="GOA:O32208" /db_xref="InterPro:IPR005950" /db_xref="SubtiList:BG14094" /db_xref="UniProtKB/Swiss-Prot:O32208" /translation="MFKKYSIFIAALTAFLLVAGCSSNQSSTDSEKKVTLTISAAASA QDALEEIQKNYEKDHQHITIQDNYGSSGALQKQISQGAGADLFFSAAEDKFKKLVDDG DIAKKDSTELVGNEIVLVVPKNGDSPVTSFSNLAESEKIALGTPESVPAGAYGKESLT KLSLWDKVKDKIVYGKDVRQVLSYVETGNVDAGVVYKTDALVSKKVNIVDEAKADTHS PIVYPLGIVKDTKHRKEAKEFYEYLQSDEAMKVFEKYGFTAE*" /label="modA CDS" gene 2845298..2846080 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /label="modA gene" CDS 2846052..2846744 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="molybdenum transport permease" /protein_id="NP_391219.3" /db_xref="EnsemblGenomes-Gn:BSU33390" /db_xref="EnsemblGenomes-Tr:CAB15344" /db_xref="GOA:O32209" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011867" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14095" /db_xref="UniProtKB/Swiss-Prot:O32209" /translation="MRNMALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAW MSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWW AAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLT GSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISF LMLFFIQQKKTH*" /label="modB CDS" gene 2846052..2846744 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /label="modB gene" downshifts 2846736 /Source="Nicolas_upshifts" /id="D1730" /incds=0 /nref=40 /ntot=195 /MaxReadThrough="0.43895" /MaxDrop="4.92503" /score="19.0609965" /energy="-9.4" /TU="NA" /idTUdmin="U2618" /TUdmin=9 /isTUend="TRUE" /label="downshifts" CDS complement(2846775..2847605) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /EC_number="1.1.1.283" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544192, 16232966, 17114254, 19585557" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544192, 16232966, 17114254, 19585557; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous glyoxal/methylglyoxal reductase" /protein_id="NP_391220.1" /db_xref="EnsemblGenomes-Gn:BSU33400" /db_xref="EnsemblGenomes-Tr:CAB15345" /db_xref="GOA:O32210" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3D3F" /db_xref="PDB:3F7J" /db_xref="SubtiList:BG14096" /db_xref="UniProtKB/Swiss-Prot:O32210" /translation="MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNG YRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQ LDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVI LRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF *" /label="pgoN CDS" gene complement(2846775..2847605) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /label="pgoN gene" downshifts complement(2846781) /Source="Nicolas_upshifts" /id="D1731" /incds=0 /nref=190 /ntot=269 /MaxReadThrough="4.7445" /MaxDrop="7.9269" /score="27.8070829" /energy="-9.7" /TU="U2620" /idTUdmin="U2620" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2847468..2847472 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2847488..2847492 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2847497 /Source="Nicolas_upshifts" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2847607 /Source="Nicolas_upshifts" /id="D1732" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="0.95687" /MaxDrop="4.12116" /score="31.5807071" /energy="-11.6" /TU="NA" /idTUdmin="U2618" /TUdmin=880 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2847635..2847654) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2847653) /Source="Nicolas_upshifts" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2847669..2847676) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2847761..2847767 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2847781 /Source="Nicolas_upshifts" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2847782..2847800 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2847828..2848313 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 22307285, 25217289; Product type f: factor" /codon_start=1 /transl_table=11 /product="exported stress induced factor" /protein_id="NP_391221.1" /db_xref="EnsemblGenomes-Gn:BSU33410" /db_xref="EnsemblGenomes-Tr:CAB15346" /db_xref="SubtiList:BG14097" /db_xref="UniProtKB/Swiss-Prot:O32211" /translation="MKRIRIPMTLALGAALTIAPLSFASAEENPAPKMSQTTTAGTTA ADVGLNVNLDVLGIANQIADAIKSAQNRDGFVKNLMESSFYASGQKYNVMVFNLSQEY EDHLNGVQFYGSAVYDGITYGIWVFEDGTFTNKGDGGWINWAFRGWFDRDGSTVAFHR P*" /label="yvgO CDS" gene 2847828..2848313 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /label="yvgO gene" downshifts 2848312 /Source="Nicolas_upshifts" /id="D1733" /incds=0 /nref=18 /ntot=93 /MaxReadThrough="3.44281" /MaxDrop="6.83046" /score="31.5807071" /energy="-11.6" /TU="U2621" /idTUdmin="U2621" /TUdmin="-571" /isTUend="FALSE" /label="downshifts" CDS complement(2848357..2850369) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16021482, 16850406, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16021482, 16850406, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_391222.1" /db_xref="EnsemblGenomes-Gn:BSU33420" /db_xref="EnsemblGenomes-Tr:CAB15347" /db_xref="GOA:O32212" /db_xref="InterPro:IPR004705" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR018422" /db_xref="SubtiList:BG14098" /db_xref="UniProtKB/Swiss-Prot:O32212" /translation="MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFP QGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYT IHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTM HMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNI ILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFW NGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILF LAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNK TASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPE ETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRA TRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLE VKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE*" /label="nhaK CDS" gene complement(2848357..2850369) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /label="nhaK gene" downshifts complement(2848365) /Source="Nicolas_upshifts" /id="D1734" /incds=0 /nref=118 /ntot=238 /MaxReadThrough="2.66359" /MaxDrop="5.82216" /score="41.6492295" /energy="-13.2" /TU="NA" /idTUdmin="U2622" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2850035..2850039) /Source="Nicolas_upshift_promotors" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2850037) /Source="Nicolas_upshifts" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2850370..2850521) /Source="Nicolas_S_feature" /locus_tag="new_3430344_3430495_c" /HighExp="dia5, T0.30H, T-0.40H, Salt, Diami, T1.0H, T0.0H, T1.30H, dia15, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.746, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1281" misc_feature complement(2850498..2850516) /Source="Nicolas_upshift_promotors" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2850521) /Source="Nicolas_upshifts" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2850624..2852339) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (hemoprotein beta-subunit)" /protein_id="NP_391223.1" /db_xref="EnsemblGenomes-Gn:BSU33430" /db_xref="EnsemblGenomes-Tr:CAB15348" /db_xref="GOA:O32213" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR011786" /db_xref="InterPro:IPR036136" /db_xref="SubtiList:BG14099" /db_xref="UniProtKB/Swiss-Prot:O32213" /translation="MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPD DDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQ KYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQ SEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKI GIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGF CRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEA KPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRL TANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAE RYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLG AAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDG TNFHD*" /label="cysI CDS" gene complement(2850624..2852339) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /label="cysI gene" downshifts complement(2850631) /Source="Nicolas_upshifts" /id="D1735" /incds=0 /nref=211 /ntot=254 /MaxReadThrough="3.28258" /MaxDrop="6.31358" /score="23.5256972" /energy="-13.8" /TU="U2624" /idTUdmin="U2624" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" CDS complement(2852365..2854182) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (flavoprotein alpha-subunit)" /protein_id="NP_391224.1" /db_xref="EnsemblGenomes-Gn:BSU33440" /db_xref="EnsemblGenomes-Tr:CAB15349" /db_xref="GOA:O32214" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010199" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14100" /db_xref="UniProtKB/Swiss-Prot:O32214" /translation="MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSA QEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSM SDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDS SYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAA PAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDS LGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQ AAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPAR LYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQN FKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEW QNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAH DVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY*" /label="cysJ CDS" gene complement(2852365..2854182) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /label="cysJ gene" promotor_-10 complement(2854224..2854243) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2854233..2854240 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2854243) /Source="Nicolas_upshifts" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" upshifts 2854246 /Source="Nicolas_upshifts" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2854253..2854272 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2854256..2854263) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2854353..2856677) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544244, 24520113" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544244, 24520113; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription factor" /protein_id="NP_391225.1" /db_xref="EnsemblGenomes-Gn:BSU33450" /db_xref="EnsemblGenomes-Tr:CAB15350" /db_xref="GOA:O32215" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="SubtiList:BG14101" /db_xref="UniProtKB/Swiss-Prot:O32215" /translation="MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLR KSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFG RIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGE TIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQN QIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYV SSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGIT WKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRM EQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQ REQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTR SAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAA SMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDG ADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHA HMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLY TACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE*" /label="helD CDS" gene complement(2854353..2856677) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /label="helD gene" downshifts complement(2854371) /Source="Nicolas_upshifts" /id="D1736" /incds=0 /nref=26 /ntot=168 /MaxReadThrough="1.20405" /MaxDrop="4.59044" /score="18.6044234" /energy="-8.5" /TU="NA" /idTUdmin="U2628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2856697..2856704 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2856719..2856738 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2856720..2856735) /Source="Nicolas_upshift_promotors" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2856723 /Source="Nicolas_upshifts" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2856725) /Source="Nicolas_upshifts" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2856770..2856789) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2856779) /Source="Nicolas_upshifts" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2856805..2856811) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2856815..2856834) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2856835) /Source="Nicolas_upshifts" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2856848..2856856) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2856862) /Source="Nicolas_upshifts" /id="D1737" /incds=0 /nref=19 /ntot=158 /MaxReadThrough="2.30604" /MaxDrop="4.26839" /score="16.6103553" /energy="-9.2" /TU="NA" /idTUdmin="U2630" /TUdmin=17 /isTUend="TRUE" /label="downshifts" CDS complement(2856875..2857483) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391226.1" /db_xref="EnsemblGenomes-Gn:BSU33460" /db_xref="EnsemblGenomes-Tr:CAB15351" /db_xref="GOA:O32216" /db_xref="InterPro:IPR005115" /db_xref="SubtiList:BG14102" /db_xref="UniProtKB/Swiss-Prot:O32216" /translation="MAWELLSVIGIIAFAVSGAIVAMEEEYDILGVYILGIVTAFGGG AIRNLLIGVPVSALWEQGAYFQIALLSITIVFLFPKLLLKHWNKWGNLSDAIGLAAFA IQGALYAVKMGHPLSAVIVAAVLTGSGGGIIRDLLAGRKPLVLKAEIYAVWAALGGLI VGLGWLGNSFGLYVLFFVLVVCRVCSYMFNWKLPNRSFRLDN*" /label="yvgT CDS" gene complement(2856875..2857483) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /label="yvgT gene" promotor_-10 complement(2857522..2857541) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2857539) /Source="Nicolas_upshifts" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2857557..2857561) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2857670..2858086) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391227.1" /db_xref="EnsemblGenomes-Gn:BSU33470" /db_xref="EnsemblGenomes-Tr:CAB15352" /db_xref="GOA:O32217" /db_xref="InterPro:IPR003752" /db_xref="InterPro:IPR012187" /db_xref="InterPro:IPR023380" /db_xref="SubtiList:BG14103" /db_xref="UniProtKB/Swiss-Prot:O32217" /translation="MKNRIVFLYASWVVALIAMLGSLYFSEIRKFIPCELCWYQRILM YPLVLILGIATFQGDTRVKKYVLPMAIIGAFISIMHYLEQKVPGFSGIKPCVSGVPCS GQYINWFGFITIPFLALIAFILIIIFMCLLKGEKSE*" /label="bdbC CDS" gene complement(2857670..2858086) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /label="bdbC gene" downshifts complement(2857680) /Source="Nicolas_upshifts" /id="D1738" /incds=0 /nref=120 /ntot=264 /MaxReadThrough="1.31968" /MaxDrop="6.21723" /score="26.5991603" /energy="-12.7" /TU="NA" /idTUdmin="U2631" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2858091..2858759) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11744713, 11872755, 12637552, 15661011, 17501922, 19535335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11744713, 11872755, 12637552, 15661011, 17501922, 19535335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391228.1" /db_xref="EnsemblGenomes-Gn:BSU33480" /db_xref="EnsemblGenomes-Tr:CAB15353" /db_xref="GOA:O32218" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:3EU3" /db_xref="PDB:3EU4" /db_xref="PDB:3GH9" /db_xref="PDB:3GHA" /db_xref="SubtiList:BG14104" /db_xref="UniProtKB/Swiss-Prot:O32218" /translation="MKKKQQSSAKFAVILTVVVVVLLAAIVIINNKTEQGNDAVSGQP SIKGQPVLGKDDAPVTVVEFGDYKCPSCKVFNSDIFPKIQKDFIDKGDVKFSFVNVMF HGKGSRLAALASEEVWKEDPDSFWDFHEKLFEKQPDTEQEWVTPGLLGDLAKSTTKIK PETLKENLDKETFASQVEKDSDLNQKMNIQATPTIYVNDKVIKNFADYDEIKETIEKE LKGK*" /label="bdbD CDS" gene complement(2858091..2858759) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /label="bdbD gene" promotor_-10 complement(2858811..2858830) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2858826) /Source="Nicolas_upshifts" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2858837) /Source="Nicolas_upshifts" /id="D1739" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="7.34296" /MaxDrop="3.6233" /score="12.4442247" /energy="-11.3" /TU="U2632" /idTUdmin="U2633" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2858844..2858849) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2858879..2860987) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /EC_number="3.6.3.3" /EC_number="3.6.3.5" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Cd(II), Zn(II) and Co(II) exporter (ATPase)" /protein_id="NP_391229.3" /db_xref="EnsemblGenomes-Gn:BSU33490" /db_xref="EnsemblGenomes-Tr:CAB15354" /db_xref="GOA:O32219" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14105" /db_xref="UniProtKB/Swiss-Prot:O32219" /translation="MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTL TVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVI LGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFL IQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSED VQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGV LHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPP LVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEAL NQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAY GKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAV DQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYA ELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAA DIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSD VGVTLLAVANAMRVMRLKNK*" /label="cadA CDS" gene complement(2858879..2860987) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /label="cadA gene" S_feature complement(2860979..2861080) /Source="Nicolas_S_feature" /locus_tag="new_3440953_3441054_c" /HighExp="dia5, LBGtran, LBGstat, Diami, LBGexp, Gly, Lbtran, T0.30H, M40t45, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 0.999" /TUlongSig="SigB" /TUlongPSig="0.587" /label="S1282" promotor_-10 complement(2861074..2861093) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2861080) /Source="Nicolas_upshifts" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2861109..2861116) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2861147..2863555) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /EC_number="3.6.3.54" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper transporter ATPase" /protein_id="NP_391230.2" /db_xref="EnsemblGenomes-Gn:BSU33500" /db_xref="EnsemblGenomes-Tr:CAB15355" /db_xref="GOA:O32220" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="PDB:1JWW" /db_xref="PDB:1KQK" /db_xref="PDB:1OPZ" /db_xref="PDB:1OQ3" /db_xref="PDB:1OQ6" /db_xref="PDB:1P6T" /db_xref="PDB:2RML" /db_xref="PDB:2VOY" /db_xref="SubtiList:BG14106" /db_xref="UniProtKB/Swiss-Prot:O32220" /translation="MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATET SNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVA NAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTA RLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAY KALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGK LFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVD GEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHII KIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAV LVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGK PRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVG AGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVA VADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAE IARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIAD AIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRL QKVK*" /label="copA CDS" gene complement(2861147..2863555) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /label="copA gene" downshifts complement(2861169) /Source="Nicolas_upshifts" /id="D1740" /incds=0 /nref=15 /ntot=68 /MaxReadThrough="5.02116" /MaxDrop="3.63756" /score="26.9828242" /energy="-7.9" /TU="U2633" /idTUdmin="U2635" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2861235) /Source="Nicolas_upshifts" /id="D1741" /incds=1 /nref=52 /ntot=227 /MaxReadThrough="5.93949" /MaxDrop="4.28993" /score="26.9828242" /energy="-7.9" /TU="U2633,U2635" /idTUdmin="U2635" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2863556..2863638) /Source="Nicolas_S_feature" /locus_tag="new_3443530_3443612_c" /HighExp="Diami, dia5, dia15, Gly, T0.30H, Heat, T1.0H, T1.30H, T0.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.999, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S1283" CDS complement(2863639..2863848) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344; Product type f: factor" /codon_start=1 /transl_table=11 /product="copper insertion chaperone and transporter component" /protein_id="NP_391231.1" /db_xref="EnsemblGenomes-Gn:BSU33510" /db_xref="EnsemblGenomes-Tr:CAB15356" /db_xref="GOA:O32221" /db_xref="InterPro:IPR000428" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR036163" /db_xref="PDB:1K0V" /db_xref="PDB:1P8G" /db_xref="PDB:2QIF" /db_xref="PDB:3I9Z" /db_xref="SubtiList:BG14107" /db_xref="UniProtKB/Swiss-Prot:O32221" /translation="MEQKTLQVEGMSCQHCVKAVETSVGELDGVSAVHVNLEAGKVDV SFDADKVSVKDIADAIEDQGYDVAK*" /label="copZ CDS" gene complement(2863639..2863848) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /label="copZ gene" promotor_-10 complement(2863872..2863891) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-10" upshifts complement(2863893) /Source="Nicolas_upshifts" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="upshifts" promotor_-35 complement(2863904..2863910) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-35" CDS complement(2863922..2864227) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17143269, 18048925, 22904286, 24831014, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17143269, 18048925, 22904286, 24831014, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of copper utilisation proteins-Cu(I)" /protein_id="NP_391232.1" /db_xref="EnsemblGenomes-Gn:BSU33520" /db_xref="EnsemblGenomes-Tr:CAB15357" /db_xref="GOA:O32222" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG14108" /db_xref="UniProtKB/Swiss-Prot:O32222" /translation="MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRY CVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS* " /label="csoR CDS" gene complement(2863922..2864227) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /label="csoR gene" misc_feature 2864191..2864210 /Source="Nicolas_upshift_promotors" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2864202 /Source="Nicolas_upshifts" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2864241..2864260) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-10" upshifts complement(2864267) /Source="Nicolas_upshifts" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="upshifts" promotor_-35 complement(2864274..2864280) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-35" promotor_-35 2864319..2864325 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2864340..2864358 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2864348 /Source="Nicolas_upshifts" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2864355..2865431 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /EC_number="1.1.1.371" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15937154, 20133360, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 20133360, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NADP(+)-dependent)" /protein_id="NP_391233.1" /db_xref="EnsemblGenomes-Gn:BSU33530" /db_xref="EnsemblGenomes-Tr:CAB15358" /db_xref="GOA:O32223" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="PDB:3GDO" /db_xref="PDB:3GFG" /db_xref="SubtiList:BG14057" /db_xref="UniProtKB/Swiss-Prot:O32223" /translation="MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKI MTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVM EKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVS YNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETV DYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPED DSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEG INVIRIIEAAMESSKEKRTIMLEH*" /label="iolW CDS" gene 2864355..2865431 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /label="iolW gene" downshifts 2865418 /Source="Nicolas_upshifts" /id="D1742" /incds=0 /nref=155 /ntot=248 /MaxReadThrough="2.17322" /MaxDrop="6.48885" /score="-5.36701412" /energy="-19.4" /TU="NA" /idTUdmin="U2636" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2865468..2866103) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17284825, 17725564, 18208493" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17284825, 17725564, 18208493; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:dichloroindophenol oxidoreductase (2-methylhydroquinone resistance)" /protein_id="NP_391234.1" /db_xref="EnsemblGenomes-Gn:BSU33540" /db_xref="EnsemblGenomes-Tr:CAB15359" /db_xref="GOA:O32224" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14058" /db_xref="UniProtKB/Swiss-Prot:O32224" /translation="MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDL YKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPL WNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEME MGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF*" /label="azoRB CDS" gene complement(2865468..2866103) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /label="azoRB gene" downshifts complement(2865481) /Source="Nicolas_upshifts" /id="D1743" /incds=0 /nref=211 /ntot=263 /MaxReadThrough="1.58189" /MaxDrop="6.89477" /score="31.0885268" /energy="-15.4" /TU="NA" /idTUdmin="U2637" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2866104..2866201) /Source="Nicolas_S_feature" /locus_tag="new_3446078_3446175_c" /HighExp="Heat, UNK1, G/S, Salt, HiTm, GM-0.1, MG 25, SMM, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1284" promotor_-10 complement(2866181..2866200) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2866201) /Source="Nicolas_upshifts" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2866214..2866220) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2866263..2868158) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12107147, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391235.1" /db_xref="EnsemblGenomes-Gn:BSU33550" /db_xref="EnsemblGenomes-Tr:CAB15360" /db_xref="GOA:O32225" /db_xref="SubtiList:BG14059" /db_xref="UniProtKB/Swiss-Prot:O32225" /translation="MNKTAANNQRIMPIVKDAFRIHANPFPWKKAIGSGFASGFPVLV GALAGHTDYGLIASIGGFVYLYAGGESYKKRALKLLLVSIGIALSFGLGTLLSGMLWM MAAVLGLIGAAAMFIFSALGIQGPAPMFFVLAFLVSSGLPADPSQALFRAGLTFLGGI FAMGIALIGWLWNKHGPEGAVLQKTYHQLAACLSAVGTPGFHNAQHQTVLMLRTARQT VLGKGNRRKKSRHDERFFRLLEKADDIFIAIIHFSAETPDRETAQIEKALRQTGDMLA NARVFNTFQINENESEPRRKLFEEINEVLYIASGRFDKQLDGEPSRLPSSFYFLRNAF DWKSPVLIRALKYGIVLFAADMFALAFGFARSYWIPLSAAAVMLGTTVVFTLHRAIQR SAGTVIGVILAGAILFFKPGGVYIAFCIAALQCLLEMLIVRNYALAVPFLTANALVIT ESMHGGAGAGYFMIARLTDVAVGSVIGLLGTMLLWRRFSTKRLPELVRNVIRLEGQFM EKLLTGQIADEHKLRVSLVRLRDAYDKALGEFPHANADALWPAISGAQHLGYYLLSAQ AHRRPSAPFSDEEINQLRAFFEQAEQSFIMKRMPADIQVPHVPHYPRISKELSALYSG LRTAFEK*" /label="yvaC CDS" gene complement(2866263..2868158) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /label="yvaC gene" promotor_-10 complement(2868209..2868220) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2868209) /Source="Nicolas_upshifts" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2868235..2868241) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2868308) /Source="Nicolas_upshifts" /id="D1744" /incds=0 /nref=20 /ntot=155 /MaxReadThrough="2.49984" /MaxDrop="4.21522" /score="11.4033831" /energy="-8" /TU="NA" /idTUdmin="U2639" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2868321..2868722) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391236.1" /db_xref="EnsemblGenomes-Gn:BSU33560" /db_xref="EnsemblGenomes-Tr:CAB15361" /db_xref="GOA:O32226" /db_xref="InterPro:IPR020348" /db_xref="SubtiList:BG14060" /db_xref="UniProtKB/Swiss-Prot:O32226" /translation="MRYMKLFFLVTDIGFILYWLSAGFSLIPESWAFKHHDHPFMIAW NWSFFPLDILISVTGLYSLYLQRVNRADWKLMALISLVLTCCSGLQALSFWTFSSDFD LVWWLFNGYLLIYPLFFIHLLLKEGRRTKQS*" /label="yvaD CDS" gene complement(2868321..2868722) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /label="yvaD gene" CDS complement(2868719..2869078) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948170, 15849754, 16850406, 19549332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite-efflux transporter" /protein_id="NP_391237.1" /db_xref="EnsemblGenomes-Gn:BSU33570" /db_xref="EnsemblGenomes-Tr:CAB15362" /db_xref="GOA:O32227" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG14061" /db_xref="UniProtKB/Swiss-Prot:O32227" /translation="MNWVFLCLAILFEVAGTVSMKLSSGFTKLIPSLLLIFFYGGSLF FLTLTLKSIDVSVAYAVWSGMGIVLITVVGFLFFQEHVSVMKVISIGLIIAGVVSLNL IEHVAVSEPVHKSGQYK*" /label="yvaE CDS" gene complement(2868719..2869078) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /label="yvaE gene" CDS complement(2869075..2869647) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391238.1" /db_xref="EnsemblGenomes-Gn:BSU33580" /db_xref="EnsemblGenomes-Tr:CAB15363" /db_xref="GOA:O32228" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14062" /db_xref="UniProtKB/Swiss-Prot:O32228" /translation="MDKRILAETFRLIKQKGFSFTMNDLAAALGTSKRTLYAYYSSKD QLVEAVVEQFIAEMKQIERDIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKY HYDAWLTLDAFIKEEWAIVLALLNECKQQKRIRNINPDLFVHMYIGSINQVYDPEYPL KHQFTTGEVLESIVDVLFNGITADEEADAT*" /label="yvaF CDS" gene complement(2869075..2869647) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /label="yvaF gene" promotor_-10 complement(2869685..2869704) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2869690) /Source="Nicolas_upshifts" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2869718..2869725) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2869758..2870552) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391239.1" /db_xref="EnsemblGenomes-Gn:BSU33590" /db_xref="EnsemblGenomes-Tr:CAB15364" /db_xref="GOA:O32229" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14063" /db_xref="UniProtKB/Swiss-Prot:O32229" /translation="MKLNLQGKTALVTGSTSGIGKAIASSLAEEGAAVIINGRREEKV NQTIDELKTQHAEAVLYPAAFDLGTEEGCNELFQAYPEVDILVNNLGIFEPAEYFDIP DDEWFRFFEVNIMSGVRLTRRYLHNMIEKKEGRVIFIASEAAIMPSQEMAHYSATKTM QLSISRSLAELATGTNVTVNTVMPGSTLTEGVETMLNSLYPGENLTVQEAEARFMKEN RPTSIIQRLIRPEEIAHFVTFLSSPLSSAINGAALRADGGLVRSVF*" /label="yvaG CDS" gene complement(2869758..2870552) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /label="yvaG gene" promotor_-10 complement(2870573..2870591) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2870585) /Source="Nicolas_upshifts" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2870606..2870612) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2870618..2870637) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2870629) /Source="Nicolas_upshifts" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2870631..2870696) /Source="Nicolas_S_feature" /locus_tag="new_3450605_3450670_c" /HighExp="H2O2, Heat, Diami, G180, Paraq, dia15, Oxctl, BMM, G135, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.47, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="0.996, 1" /label="S1285" promotor_-35 complement(2870651..2870658) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2870738..2871097) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /product="transfer-messenger RNA (tmRNA, 10Sa RNA)" /experiment="publication(s) with functional evidences, PMID:11395451, 11918677, 14766921, 17369301, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11918677, 14766921, 17369301, 18673456" /label="ssrA RNA" gene complement(2870738..2871097) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /label="ssrA gene" downshifts complement(2870741) /Source="Nicolas_upshifts" /id="D1745" /incds=0 /nref=260 /ntot=272 /MaxReadThrough="4.32959" /MaxDrop="9.81359" /score="26.7868133" /energy="-15.8" /TU="U2642,U2644" /idTUdmin="U2643" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2871081..2871089) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2871091) /Source="Nicolas_upshifts" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2871104..2871109) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2871149..2871168) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2871157) /Source="Nicolas_upshifts" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2871159..2871223) /Source="Nicolas_S_feature" /locus_tag="new_3451133_3451197_c" /HighExp="Etha, C90, dia5, dia15, Diami, T0.0H, T-0.40H, T-1.40H, LPhT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.997, 0.996, 1" /TUlongSig="SigB, SigA" /TUlongPSig="0.999, 0.753" /label="S1286" promotor_-35 complement(2871181..2871185) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2871223) /Source="Nicolas_upshifts" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="upshifts" promotor_-10 complement(2871224..2871243) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-10" promotor_-35 complement(2871258..2871265) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-35" CDS complement(2871274..2871744) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10947848, 11395451, 11918677, 12682299, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10947848, 11395451, 11918677, 12682299, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="tmRNA-binding protein" /protein_id="NP_391240.1" /db_xref="EnsemblGenomes-Gn:BSU33600" /db_xref="EnsemblGenomes-Tr:CAB15365" /db_xref="GOA:O32230" /db_xref="InterPro:IPR000037" /db_xref="InterPro:IPR020081" /db_xref="InterPro:IPR023620" /db_xref="SubtiList:BG14064" /db_xref="UniProtKB/Swiss-Prot:O32230" /translation="MPKGSGKVLSQNKKANHDYFIEETYETGIVLQGTEIKSIRAGRV NLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLMHRKEINKLIGLTKEKG YSLVPLKLYLKNGFAKVLLGLGKGKKNYDKREDLKRKDAKREIERAFRDSQKGF*" /label="smpB CDS" gene complement(2871274..2871744) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /label="smpB gene" promotor_no_box 2871571..2871671 /Source="Nicolas_upshift_promotors" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2871631 /Source="Nicolas_upshifts" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2871741 /Source="Nicolas_upshifts" /id="D1746" /incds=0 /nref=2 /ntot=105 /MaxReadThrough="0.62459" /MaxDrop="3.18501" /score="-9.3042809" /energy="-3.3" /TU="NA" /idTUdmin="U2647" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2871789..2871808) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2871795) /Source="Nicolas_upshifts" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" S_feature complement(2871797..2871888) /Source="Nicolas_S_feature" /locus_tag="new_3451771_3451862_c" /HighExp="Etha, S8, Cold, S7, G135, G180, G150, H2O2, M9-stat, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig="0.753" /label="S1287" promotor_-35 complement(2871824..2871827) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" CDS complement(2871889..2874228) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /EC_number="3.1.13.1" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 19215769, 22333191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 19215769, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease R" /protein_id="NP_391241.1" /db_xref="EnsemblGenomes-Gn:BSU33610" /db_xref="EnsemblGenomes-Tr:CAB15366" /db_xref="GOA:O32231" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004476" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR011805" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013223" /db_xref="InterPro:IPR022966" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14065" /db_xref="UniProtKB/Swiss-Prot:O32231" /translation="MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVK ALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNE LNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHK HGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKL DDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNP KVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPL VPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEE FMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRA LQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDL IVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYML DKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNV FRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTN TPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK*" /label="rnr CDS" gene complement(2871889..2874228) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /label="rnr gene" promotor_-35 2872989..2872992 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2873008..2873011 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2873017 /Source="Nicolas_upshifts" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2874247..2874987) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1369099, 17369301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase" /protein_id="NP_391242.2" /db_xref="EnsemblGenomes-Gn:BSU33620" /db_xref="EnsemblGenomes-Tr:CAB15367" /db_xref="GOA:O32232" /db_xref="InterPro:IPR012354" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14066" /db_xref="UniProtKB/Swiss-Prot:O32232" /translation="MKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYT CHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKL GYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPM NTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYE ESGHVITLDKERDLVHQDVYEFLEKLDW*" /label="estA CDS" gene complement(2874247..2874987) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /label="estA gene" promotor_-10 complement(2874643..2874661) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-10" upshifts complement(2874655) /Source="Nicolas_upshifts" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="upshifts" promotor_-35 complement(2874676..2874682) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-35" misc_feature complement(2875015..2875033) /Source="Nicolas_upshift_promotors" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2875029) /Source="Nicolas_upshifts" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="upshifts" downshifts complement(2875117) /Source="Nicolas_upshifts" /id="D1747" /incds=0 /nref=30 /ntot=212 /MaxReadThrough="6.16751" /MaxDrop="5.2246" /score="-4.14736839" /energy="-9.1" /TU="U2650" /idTUdmin="U2649" /TUdmin="-3234" /isTUend="FALSE" /label="downshifts" CDS complement(2875119..2875349) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10074070, 10644701, 16243836" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074070, 10644701, 16243836; Product type f: factor" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_391243.1" /db_xref="EnsemblGenomes-Gn:BSU33630" /db_xref="EnsemblGenomes-Tr:CAB15368" /db_xref="GOA:O32233" /db_xref="InterPro:IPR004692" /db_xref="SubtiList:BG14067" /db_xref="UniProtKB/Swiss-Prot:O32233" /translation="MHAVLITLLVIVSIALIIVVLLQSSKSAGLSGAISGGAEQLFGK QKARGLDLILHRITVVLAVLFFVLTIALAYIL*" /label="secG CDS" gene complement(2875119..2875349) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /label="secG gene" promotor_-10 complement(2875379..2875398) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2875400) /Source="Nicolas_upshifts" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" promotor_-35 complement(2875413..2875416) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" promotor_-35 2875438..2875444 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2875458..2875469 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2875459 /Source="Nicolas_upshifts" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="upshifts" CDS 2875498..2876268 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391244.1" /db_xref="EnsemblGenomes-Gn:BSU33640" /db_xref="EnsemblGenomes-Tr:CAB15369" /db_xref="GOA:O32234" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14068" /db_xref="UniProtKB/Swiss-Prot:O32234" /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKVFYYQRLLSK HFRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHI GFTRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLR SILTDHMKKADQAHWHQYYLDSLGYNCIEQLPRLEMPMLFMYGGLRDWTFTNAGYYRR SCRHAEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS*" /label="yvaM CDS" gene 2875498..2876268 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /label="yvaM gene" promotor_-35 2875520..2875528 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2875539..2875557 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2875569 /Source="Nicolas_upshifts" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2876308..2876541) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional regulator" /protein_id="NP_391245.1" /db_xref="EnsemblGenomes-Gn:BSU33650" /db_xref="EnsemblGenomes-Tr:CAB15370" /db_xref="GOA:O32235" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG14159" /db_xref="UniProtKB/Swiss-Prot:O32235" /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNG ERRPGQLVIGKMLHYFNLKFEDLFYYDFVDKSQ*" /label="yvzC CDS" gene complement(2876308..2876541) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /label="yvzC gene" promotor_-35 2876632..2876639 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-35" upshifts 2876647 /Source="Nicolas_upshifts" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="upshifts" promotor_-10 2876651..2876670 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-10" CDS 2876693..2877100 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_391246.1" /db_xref="EnsemblGenomes-Gn:BSU33660" /db_xref="EnsemblGenomes-Tr:CAB15371" /db_xref="GOA:O32236" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14069" /db_xref="UniProtKB/Swiss-Prot:O32236" /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVP KPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLE NEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD*" /label="rghRA CDS" gene 2876693..2877100 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /label="rghRA gene" CDS 2877130..2877549 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional repressor" /protein_id="NP_391247.1" /db_xref="EnsemblGenomes-Gn:BSU33670" /db_xref="EnsemblGenomes-Tr:CAB15372" /db_xref="GOA:O32237" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14070" /db_xref="UniProtKB/Swiss-Prot:O32237" /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTP KPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHL PIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS*" /label="rghRB CDS" gene 2877130..2877549 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /label="rghRB gene" promotor_-35 2877587..2877594 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2877608..2877627 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2877615 /Source="Nicolas_upshifts" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2877641..2877967 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20639328; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catechol dioxygenase" /protein_id="NP_391248.2" /db_xref="EnsemblGenomes-Gn:BSU33680" /db_xref="EnsemblGenomes-Tr:CAB15373" /db_xref="GOA:O32238" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14071" /db_xref="UniProtKB/Swiss-Prot:O32238" /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALP NLSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWI DPSFLD*" /label="catR CDS" gene 2877641..2877967 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /label="catR gene" S_feature 2877968..2878052 /Source="Nicolas_S_feature" /locus_tag="new_3457942_3458026" /HighExp="Cold, H2O2, Diami, LBGstat, LPhT, dia15, G180, Paraq, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.985" /label="S1288" promotor_-35 2878023..2878030 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2878043..2878061 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2878054 /Source="Nicolas_upshifts" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2878092..2879792 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8188684, 11872722, 27899502; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative methyl-accepting transducer" /protein_id="NP_391249.1" /db_xref="EnsemblGenomes-Gn:BSU33690" /db_xref="EnsemblGenomes-Tr:CAB15374" /db_xref="GOA:O32239" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR024478" /db_xref="InterPro:IPR035440" /db_xref="SubtiList:BG14072" /db_xref="UniProtKB/Swiss-Prot:O32239" /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTK WIDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKT ISTDKEQKLFEQLQTKVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTIT QLVDLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMK ESANHIAEGDLSNDMEALNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQV LATATNETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITIS DTSQNVLELAVSGNENMATSLQQMKTIHHIVEEAVHKVRSLEQHSQDINKLVQVINGI AEQTNLLSLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVNGTQQEIH TVITYLESSFTEVEKGTENLTDTGQAMQHIKQSVTHVADSIKEVTDGLKQLTNQSITI NQSIENIASVSEESAAGIEETFSITEQSAHSMDQVLLNAEELEQLANELNEKMGQFTI *" /label="yvaQ CDS" gene 2878092..2879792 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /label="yvaQ gene" S_feature complement(2878808..2879801) /Source="Nicolas_S_feature" /locus_tag="new_3458782_3459775_c" /HighExp="S6, S5, S7, C30, S8, S4, S3, LoTm, BT, B36" /AntisenseName="yvaQ" /AntisenseCor="-0.38660715434937498" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1289" downshifts 2879770 /Source="Nicolas_upshifts" /id="D1748" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="1.43789" /MaxDrop="3.86744" /score="26.1532813" /energy="-12.2" /TU="NA" /idTUdmin="U2655" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2879832..2880512) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391250.1" /db_xref="EnsemblGenomes-Gn:BSU33700" /db_xref="EnsemblGenomes-Tr:CAB15375" /db_xref="GOA:P39775" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12636" /db_xref="UniProtKB/Swiss-Prot:P39775" /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAG ILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTG AKHVQSAA*" /label="opuBD CDS" gene complement(2879832..2880512) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /label="opuBD gene" downshifts complement(2879846) /Source="Nicolas_upshifts" /id="D1749" /incds=0 /nref=119 /ntot=171 /MaxReadThrough="3.12805" /MaxDrop="5.39624" /score="35.0134287" /energy="-12.2" /TU="NA" /idTUdmin="U2657" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2880206..2880212 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2880227..2880245 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2880232..2882983 /Source="Nicolas_S_feature" /locus_tag="new_3460206_3462957" /HighExp="Sw, M9-stat, B60, Salt, LoTm, T0.30H, BC, Gly, B36, T1.0H" /AntisenseName="opuBC" /AntisenseCor="-0.13125567572652899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1290" upshifts 2880232 /Source="Nicolas_upshifts" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2880529..2881449) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (choline-binding lipoprotein)" /protein_id="NP_391251.1" /db_xref="EnsemblGenomes-Gn:BSU33710" /db_xref="EnsemblGenomes-Tr:CAB15376" /db_xref="GOA:Q45462" /db_xref="InterPro:IPR007210" /db_xref="PDB:3R6U" /db_xref="SubtiList:BG12635" /db_xref="UniProtKB/Swiss-Prot:Q45462" /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMS ESEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTL RMEPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVK KWAPQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLA YSTDGRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATM QELNYEVDGNLKEPSVVAKEYLEKHRYFES*" /label="opuBC CDS" gene complement(2880529..2881449) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /label="opuBC gene" CDS complement(2881461..2882114) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391252.1" /db_xref="EnsemblGenomes-Gn:BSU33720" /db_xref="EnsemblGenomes-Tr:CAB15377" /db_xref="GOA:Q45461" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12634" /db_xref="UniProtKB/Swiss-Prot:Q45461" /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVL TRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS* " /label="opuBB CDS" gene complement(2881461..2882114) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /label="opuBB gene" CDS complement(2882131..2883276) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 18321243, 21658392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 18321243, 21658392; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (ATP-binding protein)" /protein_id="NP_391253.1" /db_xref="EnsemblGenomes-Gn:BSU33730" /db_xref="EnsemblGenomes-Tr:CAB15378" /db_xref="GOA:Q45460" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12633" /db_xref="UniProtKB/Swiss-Prot:Q45460" /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTT MKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLM RQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVR KILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS*" /label="opuBA CDS" gene complement(2882131..2883276) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /label="opuBA gene" S_feature complement(2883277..2883344) /Source="Nicolas_S_feature" /locus_tag="new_3463251_3463318_c" /HighExp="T5.0H, T3.30H, T3.0H, T-5.40H, T4.0H, T-0.40H, T-1.40H, T2.30H, T-3.40H, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1291" upshifts complement(2883344) /Source="Nicolas_upshifts" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2883345..2883364) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2883375..2883379 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2883379..2883382) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2883395..2883413 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2883400 /Source="Nicolas_upshifts" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2883495..2883499 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2883515..2883534 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2883518 /Source="Nicolas_upshifts" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" CDS 2883560..2884093 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (controlling choline uptake)" /protein_id="NP_391254.2" /db_xref="EnsemblGenomes-Gn:BSU33740" /db_xref="EnsemblGenomes-Tr:CAB15379" /db_xref="GOA:C0SPB8" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14073" /db_xref="UniProtKB/Swiss-Prot:C0SPB8" /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNR KPMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITL FSATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSR LIEFFESEDIFKYVPKP*" /label="yvaV CDS" gene 2883560..2884093 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /label="yvaV gene" S_feature complement(2883760..>2884159) /Source="Nicolas_S_feature" /locus_tag="new_3463734_3464253_c" /HighExp="S8, Cold, C30, GM 25, GM 60, BC, T-4.40H, M/G, GM-0.1, MG 120" /AntisenseName="yvaV" /AntisenseCor="-7.6123637680436104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.503, 1, 0.758" /TUlongSig="NA" /TUlongPSig="NA" /label="S1292" downshifts 2884082 /Source="Nicolas_upshifts" /id="D1750" /incds=0 /nref=51 /ntot=161 /MaxReadThrough="2.68472" /MaxDrop="4.69377" /score="-3.5823381" /energy="-8.6" /TU="NA" /idTUdmin="U2659" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(2884159,2884166) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs14" N_region 2884160..2884165 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs14" S_feature <2884166..2884241 /Source="Nicolas_S_feature" /locus_tag="new_3466412_3467550" /HighExp="Pyr, S8, nit, C30, GM 150, M9-stat, S7, S2, G/S, S1" /AntisenseName="sdpI" /AntisenseCor="-7.9710115369408502E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.636, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1297" S_feature complement(<2884166..2884232) /Source="Nicolas_S_feature" /locus_tag="new_3467393_3467541_c" /HighExp="Salt, B36, Gly, B60, LoTm, S8, GM 5, MG 25, Cold, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1298" CDS complement(2884237..2884926) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391260.1" /db_xref="EnsemblGenomes-Gn:BSU33800" /db_xref="EnsemblGenomes-Tr:CAB15385" /db_xref="GOA:O34742" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12640" /db_xref="UniProtKB/Swiss-Prot:O34742" /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLG ILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGN FIIADRKTTSI*" /label="opuCD CDS" gene complement(2884237..2884926) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /label="opuCD gene" downshifts complement(2884277) /Source="Nicolas_upshifts" /id="D1757" /incds=0 /nref=95 /ntot=199 /MaxReadThrough="5.55394" /MaxDrop="6.7177" /score="8.72167152" /energy="-11.6" /TU="U2667" /idTUdmin="U2667" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" promotor_-35 2884869..2884877 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2884891..2884910 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2884905 /Source="Nicolas_upshifts" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2884944..2885855) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 28256787; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (osmoprotectant-binding lipoprotein)" /protein_id="NP_391261.1" /db_xref="EnsemblGenomes-Gn:BSU33810" /db_xref="EnsemblGenomes-Tr:CAB15386" /db_xref="GOA:O32243" /db_xref="InterPro:IPR007210" /db_xref="PDB:3PPN" /db_xref="PDB:3PPO" /db_xref="PDB:3PPP" /db_xref="PDB:3PPQ" /db_xref="PDB:3PPR" /db_xref="SubtiList:BG12639" /db_xref="UniProtKB/Swiss-Prot:O32243" /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTES EIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGK EAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKN ASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYS TDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQE LNYEVDGKLKEPSVVAKEFLEKHHYFD*" /label="opuCC CDS" gene complement(2884944..2885855) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /label="opuCC gene" CDS complement(2885875..2886528) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391262.1" /db_xref="EnsemblGenomes-Gn:BSU33820" /db_xref="EnsemblGenomes-Tr:CAB15387" /db_xref="GOA:O34878" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12638" /db_xref="UniProtKB/Swiss-Prot:O34878" /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVAL TRMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIKGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS* " /label="opuCB CDS" gene complement(2885875..2886528) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /label="opuCB gene" CDS complement(2886551..2887693) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10216873, 9925583, 21658392, 27378384, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216873, 9925583, 21658392, 27378384, 27683249; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein)" /protein_id="NP_391263.1" /db_xref="EnsemblGenomes-Gn:BSU33830" /db_xref="EnsemblGenomes-Tr:CAB15388" /db_xref="GOA:O34992" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12637" /db_xref="UniProtKB/Swiss-Prot:O34992" /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTT MKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMR EKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRK ILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI*" /label="opuCA CDS" gene complement(2886551..2887693) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /label="opuCA gene" promotor_-10 complement(2887737..2887756) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-10" upshifts complement(2887752) /Source="Nicolas_upshifts" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="upshifts" promotor_-35 complement(2887771..2887774) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-35" promotor_-35 2887890..2887897 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2887910..2887929 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2887921 /Source="Nicolas_upshifts" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="upshifts" CDS 2887957..2888514 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23960087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23960087; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative transcriptional regulator of choline uptake systems" /protein_id="NP_391264.1" /db_xref="EnsemblGenomes-Gn:BSU33840" /db_xref="EnsemblGenomes-Tr:CAB15389" /db_xref="GOA:O34709" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14079" /db_xref="UniProtKB/Swiss-Prot:O34709" /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNR KPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISL FAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLS RLIEFFESEEVFRYVPKTKECSSLK*" /label="opcR CDS" gene 2887957..2888514 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /label="opcR gene" S_feature 2888515..2889279 /Source="Nicolas_S_feature" /locus_tag="new_3471824_3472588" /HighExp="HiOs, GM 5, GM 10, Salt, MG 15, MG 10, MG 25, T0.0H, T-2.40H, GM 45" /AntisenseName="yvbG" /AntisenseCor="-0.14921239095219299" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1299" CDS complement(2888532..2889167) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391265.1" /db_xref="EnsemblGenomes-Gn:BSU33850" /db_xref="EnsemblGenomes-Tr:CAB15390" /db_xref="GOA:O32244" /db_xref="InterPro:IPR002771" /db_xref="SubtiList:BG14080" /db_xref="UniProtKB/Swiss-Prot:O32244" /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARK AAILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHH DEHKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALT FLFFHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS*" /label="yvbG CDS" gene complement(2888532..2889167) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /label="yvbG gene" downshifts complement(2888545) /Source="Nicolas_upshifts" /id="D1758" /incds=0 /nref=21 /ntot=50 /MaxReadThrough="2.02169" /MaxDrop="4.45088" /score="10.9231366" /energy="-16.4" /TU="NA" /idTUdmin="U2669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2889208..2889226) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2889214) /Source="Nicolas_upshifts" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2889242..2889248) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2889253..2889260 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2889272..2889291 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2889281 /Source="Nicolas_upshifts" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2889317..2889931 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391266.1" /db_xref="EnsemblGenomes-Gn:BSU33860" /db_xref="EnsemblGenomes-Tr:CAB15391" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR021722" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG14081" /db_xref="UniProtKB/Swiss-Prot:O32245" /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFL IKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIK FKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHT RPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN*" /label="yvbH CDS" gene 2889317..2889931 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /label="yvbH gene" downshifts 2889917 /Source="Nicolas_upshifts" /id="D1759" /incds=0 /nref=110 /ntot=197 /MaxReadThrough="2.66824" /MaxDrop="5.86088" /score="-4.16829989" /energy="-7.9" /TU="U2670" /idTUdmin="U2668" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 2889985..2889988 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2890003..2890022 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2890011 /Source="Nicolas_upshifts" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2890063..2890761 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391267.1" /db_xref="EnsemblGenomes-Gn:BSU33870" /db_xref="EnsemblGenomes-Tr:CAB15392" /db_xref="GOA:O32246" /db_xref="InterPro:IPR029038" /db_xref="SubtiList:BG14082" /db_xref="UniProtKB/Swiss-Prot:O32246" /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHAAQTGAAAKQAAK QFGSFVLSVLKRPYQECKATGGEQLISAIITMVLFSLLTPLMFYILFSDGPGSVSFTA IFLEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFF LLHTDICFTILAVGLIGAFFAIPPAMLSSYQHSYKGKVDFIYSTIVIYLIICVTFQLI IEHYVKEIFRYMLF*" /label="yvbI CDS" gene 2890063..2890761 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /label="yvbI gene" downshifts 2890734 /Source="Nicolas_upshifts" /id="D1760" /incds=0 /nref=72 /ntot=203 /MaxReadThrough="1.50622" /MaxDrop="4.71846" /score="17.2112529" /energy="-17.2" /TU="U2671" /idTUdmin="U2671" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2890797..2892614) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15155184" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391268.1" /db_xref="EnsemblGenomes-Gn:BSU33880" /db_xref="EnsemblGenomes-Tr:CAB15393" /db_xref="GOA:O32247" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR026870" /db_xref="SubtiList:BG14083" /db_xref="UniProtKB/Swiss-Prot:O32247" /translation="MLFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQ APRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIAT LLTPVNDNLKLTKNNVKPFLTYLKDHPDKKDELFASLRDETAQKDIVYAEKDGKSLLV FDHYDLKVAPVYFEVSSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLK NDVVDLVKKEDIQAIGDSSFRVDLSLEADDVTFSLANDIKSGKGDLLINGKSIHKDPF KSVTYGPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIV KTTKQYSKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFA LSQKNDGTWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAE STFESAGTNIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQA DAVNQNNFSLMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITI KTYEEFYITKSGGSPKLRTYNWTYTGVVKNGRIYLTSIQ*" /label="yvbJ CDS" gene complement(2890797..2892614) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /label="yvbJ gene" downshifts complement(2890816) /Source="Nicolas_upshifts" /id="D1761" /incds=0 /nref=31 /ntot=189 /MaxReadThrough="2.6958" /MaxDrop="3.67366" /score="15.9345511" /energy="-17.2" /TU="NA" /idTUdmin="U2673" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2890987) /Source="Nicolas_upshifts" /id="D1762" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="4.6758" /MaxDrop="2.2812" /score="15.9345511" /energy="-17.2" /TU="U2673" /idTUdmin="U2673" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" misc_feature complement(2892656..2892675) /Source="Nicolas_upshift_promotors" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 2892660..2892679 /Source="Nicolas_upshift_promotors" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2892665 /Source="Nicolas_upshifts" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2892669) /Source="Nicolas_upshifts" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2892734..2893201 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acyltransferase" /protein_id="NP_391269.1" /db_xref="EnsemblGenomes-Gn:BSU33890" /db_xref="EnsemblGenomes-Tr:CAB15394" /db_xref="GOA:O32248" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YVK" /db_xref="SubtiList:BG14084" /db_xref="UniProtKB/Swiss-Prot:O32248" /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTA WAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEI GTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL*" /label="yvbK CDS" gene 2892734..2893201 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /label="yvbK gene" downshifts 2893198 /Source="Nicolas_upshifts" /id="D1763" /incds=0 /nref=199 /ntot=250 /MaxReadThrough="1.84358" /MaxDrop="5.3321" /score="15.9040274" /energy="-13.3" /TU="U2672" /idTUdmin="U2672" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2893246..2894538) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /EC_number="4.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="NP_391270.1" /db_xref="EnsemblGenomes-Gn:BSU33900" /db_xref="EnsemblGenomes-Tr:CAB15395" /db_xref="GOA:P37869" /db_xref="InterPro:IPR000941" /db_xref="InterPro:IPR020809" /db_xref="InterPro:IPR020810" /db_xref="InterPro:IPR020811" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:4A3R" /db_xref="SubtiList:BG10899" /db_xref="UniProtKB/Swiss-Prot:P37869" /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTG EYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTEN KGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNV DIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEA LQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEE LVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGN SILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTG APSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK*" /label="eno CDS" gene complement(2893246..2894538) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /label="eno gene" downshifts complement(2893256) /Source="Nicolas_upshifts" /id="D1764" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="2.21852" /MaxDrop="9.34136" /score="29.8674712" /energy="-15" /TU="NA" /idTUdmin="U2674" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2894568..2896103) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /EC_number="5.4.2.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9830105, 10869096, 12682299, 19193632, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9830105, 10869096, 12682299, 19193632, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate mutase" /protein_id="NP_391271.1" /db_xref="EnsemblGenomes-Gn:BSU33910" /db_xref="EnsemblGenomes-Tr:CAB15396" /db_xref="GOA:P39773" /db_xref="InterPro:IPR005995" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR036646" /db_xref="SubtiList:BG10898" /db_xref="UniProtKB/Swiss-Prot:P39773" /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQT LTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIS NAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTA KTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALD VVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKD FRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAET EKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKH DAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADI LITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSL IQK*" /label="pgm CDS" gene complement(2894568..2896103) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /label="pgm gene" CDS complement(2896096..2896857) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /EC_number="5.3.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8021172, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="triose phosphate isomerase" /protein_id="NP_391272.1" /db_xref="EnsemblGenomes-Gn:BSU33920" /db_xref="EnsemblGenomes-Tr:CAB15397" /db_xref="GOA:P27876" /db_xref="InterPro:IPR000652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020861" /db_xref="InterPro:IPR022896" /db_xref="InterPro:IPR035990" /db_xref="SubtiList:BG10897" /db_xref="UniProtKB/Swiss-Prot:P27876" /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPA LFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMF AETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVA ASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPAN IKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE*" /label="tpiA CDS" gene complement(2896096..2896857) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /label="tpiA gene" CDS complement(2896888..2898072) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /EC_number="2.7.2.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559176, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559176, 12682299, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate kinase" /protein_id="NP_391273.1" /db_xref="EnsemblGenomes-Gn:BSU33930" /db_xref="EnsemblGenomes-Tr:CAB15398" /db_xref="GOA:P40924" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015824" /db_xref="InterPro:IPR015911" /db_xref="InterPro:IPR036043" /db_xref="SubtiList:BG11062" /db_xref="UniProtKB/Swiss-Prot:P40924" /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTI KHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQ ISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIA EHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIG GGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDA NVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAV AEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALN DK*" /label="pgk CDS" gene complement(2896888..2898072) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /label="pgk gene" S_feature complement(2898073..2898313) /Source="Nicolas_S_feature" /locus_tag="new_3481382_3481622_c" /HighExp="Lbstat, Lbtran, C90, LBGtran, LBGexp, G150, M40t45, LPhT, M0t45, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA, SigK" /TUshortPSig="0.979, 0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1300" upshifts complement(2898313) /Source="Nicolas_upshifts" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2898315..2898388) /Source="Nicolas_S_feature" /locus_tag="new_3481624_3481697_c" /HighExp="C90, LBGtran, Lbstat, LBGexp, Lbtran, G150, M40t45, Etha, ferm, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1301" promotor_-10 complement(2898327..2898346) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2898362..2898366) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2898389..2899396) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /EC_number="1.2.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)" /protein_id="NP_391274.1" /db_xref="EnsemblGenomes-Gn:BSU33940" /db_xref="EnsemblGenomes-Tr:CAB15399" /db_xref="GOA:P09124" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10827" /db_xref="UniProtKB/Swiss-Prot:P09124" /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHL LQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTK RADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPF AKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSL VLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYS EEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKG L*" /label="gapA CDS" gene complement(2898389..2899396) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /label="gapA gene" promotor_-35 2899315..2899318 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2899335..2899337 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2899337 /Source="Nicolas_upshifts" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2899443..2900465) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489127, 12622823, 17142398, 17293407, 18052209, 18554327" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489127, 12622823, 17142398, 17293407, 18052209, 18554327; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of gapA" /protein_id="NP_391275.1" /db_xref="EnsemblGenomes-Gn:BSU33950" /db_xref="EnsemblGenomes-Tr:CAB15400" /db_xref="GOA:O32253" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OKG" /db_xref="PDB:3BXE" /db_xref="PDB:3BXF" /db_xref="PDB:3BXG" /db_xref="PDB:3BXH" /db_xref="SubtiList:BG14085" /db_xref="UniProtKB/Swiss-Prot:O32253" /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASL GISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLK ERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMM TPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSI IEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFN ADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAK KLLRDE*" /label="cggR CDS" gene complement(2899443..2900465) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /label="cggR gene" upshifts complement(2899459) /Source="Nicolas_upshifts" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2899487..2899488) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2900466..2900577) /Source="Nicolas_S_feature" /locus_tag="new_3483775_3483886_c" /HighExp="LPhT, C90, LBGtran, Heat, BI, LBGexp, Lbstat, Sw, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1302" downshifts 2900503 /Source="Nicolas_upshifts" /id="D1765" /incds=0 /nref=3 /ntot=50 /MaxReadThrough="4.48989" /MaxDrop="5.24842" /score="-9.71393179" /energy="-11.8" /TU="NA" /idTUdmin="U2675" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2900558..2900577) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2900577) /Source="Nicolas_upshifts" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2900579..2900689) /Source="Nicolas_S_feature" /locus_tag="new_3483888_3483998_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, S3, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1303" promotor_-35 complement(2900591..2900598) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2900672..2900691) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-10" upshifts complement(2900687) /Source="Nicolas_upshifts" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="upshifts" promotor_-35 complement(2900704..2900713) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-35" CDS complement(2900763..2902157) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9620981, 10417639, 15849754, 16850406, 20693325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620981, 10417639, 15849754, 16850406, 20693325; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arabinose-related compounds permease" /protein_id="NP_391276.1" /db_xref="EnsemblGenomes-Gn:BSU33960" /db_xref="EnsemblGenomes-Tr:CAB15401" /db_xref="GOA:P96710" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11907" /db_xref="UniProtKB/Swiss-Prot:P96710" /translation="MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVI SGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAI SAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTIL GISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAG KTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALF NQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLM SIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNH LRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPET KNKSLEEIEKLWIK*" /label="araE CDS" gene complement(2900763..2902157) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /label="araE gene" downshifts complement(2900777) /Source="Nicolas_upshifts" /id="D1766" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="1.15614" /MaxDrop="3.28809" /score="1.06999853" /energy="-14.6" /TU="NA" /idTUdmin="U2679" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2902256..2902275) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2902270) /Source="Nicolas_upshifts" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2902290..2902297) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2902297..2902304 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2902318..2902337 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2902324 /Source="Nicolas_upshifts" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="upshifts" CDS 2902361..2903449 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the ara regulon (LacI family)" /protein_id="NP_391277.2" /db_xref="EnsemblGenomes-Gn:BSU33970" /db_xref="EnsemblGenomes-Tr:CAB15402" /db_xref="GOA:P96711" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR033532" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3TB6" /db_xref="PDB:4EGY" /db_xref="PDB:4EGZ" /db_xref="PDB:4H0E" /db_xref="PDB:5D4R" /db_xref="PDB:5D4S" /db_xref="SubtiList:BG11913" /db_xref="UniProtKB/Swiss-Prot:P96711" /translation="MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTI RKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIE SYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLE KNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKR MNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEI ALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDC LEHKKPKQEDVIFEPELIIRQSARKLNE*" /label="araR CDS" gene 2902361..2903449 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /label="araR gene" downshifts 2903429 /Source="Nicolas_upshifts" /id="D1767" /incds=0 /nref=202 /ntot=247 /MaxReadThrough="1.17419" /MaxDrop="4.76041" /score="20.2322165" /energy="-13.6" /TU="NA" /idTUdmin="U2680" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2903498..2904508) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_391278.1" /db_xref="EnsemblGenomes-Gn:BSU33980" /db_xref="EnsemblGenomes-Tr:CAB15403" /db_xref="GOA:O32254" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG14086" /db_xref="UniProtKB/Swiss-Prot:O32254" /translation="MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGY HRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLE TLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRA IPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVL DEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEK AMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWK NR*" /label="yvbT CDS" gene complement(2903498..2904508) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /label="yvbT gene" downshifts complement(2903505) /Source="Nicolas_upshifts" /id="D1768" /incds=0 /nref=200 /ntot=252 /MaxReadThrough="1.53983" /MaxDrop="7.63266" /score="27.2032847" /energy="-14.2" /TU="NA" /idTUdmin="U2681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2904509..2904586) /Source="Nicolas_S_feature" /locus_tag="new_3487818_3487895_c" /HighExp="dia5, dia15, Diami, H2O2, Salt, Paraq, G180, Etha, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1304" promotor_-10 complement(2904576..2904595) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2904586) /Source="Nicolas_upshifts" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2904609..2904616) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2904665..2905543) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391279.1" /db_xref="EnsemblGenomes-Gn:BSU33990" /db_xref="EnsemblGenomes-Tr:CAB15404" /db_xref="GOA:O32255" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14087" /db_xref="UniProtKB/Swiss-Prot:O32255" /translation="MTITQLKVFVKIAETGSFTKAGQALNMTQPAVSHAISAIEAELD VKLIIRDRRNGLMLTDTGKQILVHIREVLKGIEKVEQVAAAEKGLELGTIHIGTFSTA SAYFMPKLISEFKQKYPKLELVLHEGTVNEVKEWLHTRMIDVGILLYPTEEMEYIHLK KDKMAVVLRDDHPLASHSAITLKDLDHEPMIVCDGGYESPFIDMFRQAGATLHPAFTV YNINTSISMIREGLGLAILSEMSMSGMPLPEHVVTRELDPQVYRDVQLAVPSLKEASL AAKLFIEMAKELFGAE*" /label="yvbU CDS" gene complement(2904665..2905543) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /label="yvbU gene" promotor_-35 2905201..2905207 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2905222..2905233 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2905233 /Source="Nicolas_upshifts" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2905577..2905584 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2905590..2905609) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-10" upshifts complement(2905595) /Source="Nicolas_upshifts" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="upshifts" promotor_-10 2905598..2905617 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2905600 /Source="Nicolas_upshifts" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2905623..2905627) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-35" CDS 2905643..2906560 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10844694, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cysteine and O-acetylserine efflux permease" /protein_id="NP_391280.1" /db_xref="EnsemblGenomes-Gn:BSU34000" /db_xref="EnsemblGenomes-Tr:CAB15405" /db_xref="GOA:O32256" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG14088" /db_xref="UniProtKB/Swiss-Prot:O32256" /translation="MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRT LIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIV FFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSA VSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLL FISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLL LIVTSICLVNTKSKAQKAAAIGINEKAAQ*" /label="cyeB CDS" gene 2905643..2906560 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /label="cyeB gene" downshifts 2906549 /Source="Nicolas_upshifts" /id="D1769" /incds=0 /nref=6 /ntot=15 /MaxReadThrough="2.97475" /MaxDrop="3.548" /score="22.9557936" /energy="-19.2" /TU="NA" /idTUdmin="U2684" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2906601..2907944) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19258532, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative leucine permease" /protein_id="NP_391281.1" /db_xref="EnsemblGenomes-Gn:BSU34010" /db_xref="EnsemblGenomes-Tr:CAB15406" /db_xref="GOA:O32257" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG14089" /db_xref="UniProtKB/Swiss-Prot:O32257" /translation="MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPS VIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVL NIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEII GVTLAETKNPEKVVPKAVRSTLTRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFK MVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMF AILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPA YYVKWFPYTTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ*" /label="yvbW CDS" gene complement(2906601..2907944) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /label="yvbW gene" misc_RNA complement(2908013..2908248) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /product="T-box riboswitch controlling synthesis of an amino acid transporter" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 18625071, 19258532; Product type n: RNA" /function="16.3: Control" /label="tboX RNA" gene complement(2908013..2908248) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /label="tboX gene" downshifts complement(2908147) /Source="Nicolas_upshifts" /id="D1770" /incds=1 /nref=1 /ntot=104 /MaxReadThrough="5.18182" /MaxDrop="2.29735" /score="33.4262209" /energy="-24.4" /TU="U2685,U2689" /idTUdmin="U2689" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2908249..2908345) /Source="Nicolas_S_feature" /locus_tag="new_3491558_3491654_c" /HighExp="Cold, GM 120, C30, GM 90, C90, GM 15, GM 10, GM 25, HPh, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1305" CDS complement(2908346..2909380) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12177332; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative epimerase modification of peptidoglycan" /protein_id="NP_391282.1" /db_xref="EnsemblGenomes-Gn:BSU34020" /db_xref="EnsemblGenomes-Tr:CAB15407" /db_xref="GOA:O32258" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG14090" /db_xref="UniProtKB/Swiss-Prot:O32258" /translation="MKKWLIIAVSLAIAIVLFMYTKGEAKAAGMTVGYTTGDTASYNS LTKYHTYMNAIATDTFAFEKNGQIIGDAPTKQLTYAKKKKIKTWAVISNYNDAIYDFD GDLASRVMSNKTAKKRFTDQLITLAKKHSYYGINIDFEAVNPEDRAAYSNFIQYVSQA LNKKHIKTMVSVPAKSADDKNDDWSWPYDYAKIGKYADFVQVMTYDEHGIWGEPGSVA STNWIKSSLQFSVKKIKANKVIMGIPAYGYDWDVKDGSTSTIREWNELKSLIKKQKAK PAFNKKSGSMTFSYVDKKKHKHVVWYENEKTVQTKSHLAKQYKIAGVSVYALGNESES FWKAIRKGTK*" /label="yvbX CDS" gene complement(2908346..2909380) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /label="yvbX gene" promotor_-10 complement(2909402..2909420) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2909408) /Source="Nicolas_upshifts" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2909433..2909440) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2909488..2910210) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22427629, 24196425, 24274019" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22427629, 24196425, 24274019; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase for L-lactate utilization" /protein_id="NP_391283.1" /db_xref="EnsemblGenomes-Gn:BSU34030" /db_xref="EnsemblGenomes-Tr:CAB15408" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR022823" /db_xref="SubtiList:BG14091" /db_xref="UniProtKB/Swiss-Prot:O32259" /translation="MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLE GYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYG LKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKD IGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADI EMDLVVGVHGPVKAAYILVSDR*" /label="lutC CDS" gene complement(2909488..2910210) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /label="lutC gene" downshifts complement(2909504) /Source="Nicolas_upshifts" /id="D1771" /incds=0 /nref=194 /ntot=266 /MaxReadThrough="4.5919" /MaxDrop="7.41457" /score="25.5917046" /energy="-15.7" /TU="U2689" /idTUdmin="U2689" /TUdmin="-1423" /isTUend="FALSE" /label="downshifts" CDS complement(2910210..2911649) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase linked to L-lactate utilization" /protein_id="NP_391284.1" /db_xref="EnsemblGenomes-Gn:BSU34040" /db_xref="EnsemblGenomes-Tr:CAB15409" /db_xref="GOA:O07021" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR004452" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR022825" /db_xref="InterPro:IPR024569" /db_xref="SubtiList:BG12448" /db_xref="UniProtKB/Swiss-Prot:O07021" /translation="MAMKIGTDAFKERVSQGIDNEFMRGAVSGAQERLRTRRLEAAEE LGNWEEWRSLSEEIRQHVLENLDFYLGQLAENVAKRGGHVYFAKTAEEASSYIRDVIQ KKNGKKIVKSKSMVTEEINLNEVLEKEGCEVVETDLGEYILQIDDHDPPSHIVAPALH KNKEQIRDVFKERLDYQHTEKPEELVMHARAILRKKFLEADIGITGCNFAIADTGSVS LVTNEGNGRLVSTLPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALT GPKLEGEVDGPEEFHLVIVDNGRSNILGTEFQSVLQCIRCAACINVCPVYRHVGGHSY GSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACSEACPVKIPLHELLLKHRQNIVE KEGRAPISEKLAMKAFGLGASSLSLYKMGSKWAPAAMTPFTEDEKISKGPGPLKNWTQ IRDFPAPHKSRFRDWFADRETSERTKEEQ*" /label="lutB CDS" gene complement(2910210..2911649) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /label="lutB gene" promotor_-35 2911197..2911200 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2911217 /Source="Nicolas_upshifts" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2911218..2911222 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2911371 /Source="Nicolas_upshifts" /id="D1772" /incds=1 /nref=1 /ntot=175 /MaxReadThrough="1.77859" /MaxDrop="3.31917" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2686" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 2911525 /Source="Nicolas_upshifts" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2911526..2911527 /Source="Nicolas_upshift_promotors" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2911676..2912392) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /EC_number="1.8.98.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-sulfur oxidase subunit used in L-lactate utilization" /protein_id="NP_391285.1" /db_xref="EnsemblGenomes-Gn:BSU34050" /db_xref="EnsemblGenomes-Tr:CAB15410" /db_xref="GOA:O07020" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR022822" /db_xref="SubtiList:BG12447" /db_xref="UniProtKB/Swiss-Prot:O07020" /translation="MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQ PAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKK LADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQ FTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGR LGRKDKNVKVMHIAEVLNSR*" /label="lutA CDS" gene complement(2911676..2912392) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /label="lutA gene" promotor_-35 2912296..2912303 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2912317..2912319 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2912317 /Source="Nicolas_upshifts" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2912390 /Source="Nicolas_upshifts" /id="D1773" /incds=0 /nref=15 /ntot=169 /MaxReadThrough="1.96527" /MaxDrop="4.662" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2688" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" S_feature complement(2912393..2912459) /Source="Nicolas_S_feature" /locus_tag="new_3495702_3495768_c" /HighExp="C90, M40t90, T3.0H, T4.0H, HiOs, T1.0H, T3.30H, T2.30H, Lbstat, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1306" promotor_-10 complement(2912456..2912475) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-10" upshifts complement(2912459) /Source="Nicolas_upshifts" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="upshifts" promotor_-35 complement(2912490..2912497) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-35" CDS complement(2912567..2913169) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvfT]" /protein_id="NP_391286.1" /db_xref="EnsemblGenomes-Gn:BSU34060" /db_xref="EnsemblGenomes-Tr:CAB15411" /db_xref="GOA:O07019" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12446" /db_xref="UniProtKB/Swiss-Prot:O07019" /translation="MIRLFIAEDQRMLLGALGSLLDLEEDMTVIGQALNGEEALHAIL KLEPDVCIMDIEMPVRSGLNVAEELMKKGCVSKVIILTTFARPGYFERAVKAGAHGYL LKDGEIDDLADAIRKCVKGKRVFSPELTFNMMRDENPLTVREQEILRLAALGKTTKDI TLELYLSQGTVRNYISEIIQKLNAKNRTEAASIAEEKGWI*" /label="yvfU CDS" gene complement(2912567..2913169) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /label="yvfU gene" CDS complement(2913186..2914301) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YvfU]" /protein_id="NP_391287.2" /db_xref="EnsemblGenomes-Gn:BSU34070" /db_xref="EnsemblGenomes-Tr:CAB15412" /db_xref="GOA:Q795K2" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12445" /db_xref="UniProtKB/Swiss-Prot:Q795K2" /translation="MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGM LLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKE KTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIE LEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTK LEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVI SPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGN GLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE*" /label="yvfT CDS" gene complement(2913186..2914301) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /label="yvfT gene" CDS complement(2914305..2915042) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391288.1" /db_xref="EnsemblGenomes-Gn:BSU34080" /db_xref="EnsemblGenomes-Tr:CAB15413" /db_xref="GOA:O07017" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12444" /db_xref="UniProtKB/Swiss-Prot:O07017" /translation="MNVLQKQSIAEMKRVLRNKYFVLWSLIMPIAFYYFFTNVVNTNV PDQRAWEAHYLMSMTVFSVMGSSIMTLGIRMVQERSQGWAAFIRLTPLPDHIYLSAQM IGQSVIHVLSITVIFLFGAIINDIALSPFEWMMSGLWILFGALPFLALGTLIGLMRKV ETAAGISNVLYMLLALGGGMWMPFEVMPDMMQSIGQWLPSYHFGSGAWELVRGGSPTW KNILILIAYMMLFMLLSKYIRRKQEAV*" /label="yvfS CDS" gene complement(2914305..2915042) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /label="yvfS gene" promotor_-10 complement(2914331..2914350) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-10" upshifts complement(2914345) /Source="Nicolas_upshifts" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="upshifts" promotor_-35 complement(2914362..2914369) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-35" CDS complement(2915043..2915948) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_391289.1" /db_xref="EnsemblGenomes-Gn:BSU34090" /db_xref="EnsemblGenomes-Tr:CAB15414" /db_xref="GOA:O07016" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12443" /db_xref="UniProtKB/Swiss-Prot:O07016" /translation="MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGK TTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRS YYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVG MDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIR SRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHA RDIRIEQATLDEAFRQLADGNREAM*" /label="yvfR CDS" gene complement(2915043..2915948) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /label="yvfR gene" promotor_-10 complement(2915968..2915986) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2915979) /Source="Nicolas_upshifts" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2916002..2916005) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2916157..2916164 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2916175..2916194 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2916182 /Source="Nicolas_upshifts" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="upshifts" CDS 2916232..2917041 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11591687, 12620626, 15632289, 21980452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591687, 12620626, 15632289, 21980452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of RsbP phosphatase" /protein_id="NP_391290.1" /db_xref="EnsemblGenomes-Gn:BSU34100" /db_xref="EnsemblGenomes-Tr:CAB15415" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR031143" /db_xref="PDB:1WOM" /db_xref="PDB:1WPR" /db_xref="SubtiList:BG12442" /db_xref="UniProtKB/Swiss-Prot:O07015" /translation="MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEED HRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIG MLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFA ATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCAD DIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV*" /label="rsbQ CDS" gene 2916232..2917041 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /label="rsbQ gene" CDS 2917077..2918288 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /EC_number="3.1.3.3" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine protein-phosphatase" /protein_id="NP_391291.1" /db_xref="EnsemblGenomes-Gn:BSU34110" /db_xref="EnsemblGenomes-Tr:CAB15416" /db_xref="GOA:O07014" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG12441" /db_xref="UniProtKB/Swiss-Prot:O07014" /translation="MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHM NMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVF DCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQ NQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHR YGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEAR HYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSS LSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKS DDECFILVDVK*" /label="rsbP CDS" gene 2917077..2918288 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /label="rsbP gene" downshifts 2918275 /Source="Nicolas_upshifts" /id="D1774" /incds=0 /nref=181 /ntot=246 /MaxReadThrough="0.90827" /MaxDrop="5.41923" /score="26.3528321" /energy="-17.8" /TU="NA" /idTUdmin="U2692" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2918342..2919631) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11682178, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,4-galactanase" /protein_id="NP_391292.2" /db_xref="EnsemblGenomes-Gn:BSU34120" /db_xref="EnsemblGenomes-Tr:CAB15417" /db_xref="GOA:O07013" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12440" /db_xref="UniProtKB/Swiss-Prot:O07013" /translation="MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVK KVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHP YDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLS FEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRA VRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSV LKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVME AVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKW YGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR*" /label="ganB CDS" gene complement(2918342..2919631) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /label="ganB gene" CDS complement(2919711..2921774) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /EC_number="3.2.1.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="short chain beta-1,4-galacto-oligosaccharides beta-galactosidase (beta-galacto-pyranoside hydrolase)" /protein_id="NP_391293.1" /db_xref="EnsemblGenomes-Gn:BSU34130" /db_xref="EnsemblGenomes-Tr:CAB15418" /db_xref="GOA:O07012" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12439" /db_xref="UniProtKB/Swiss-Prot:O07012" /translation="MMSKLEKTHVTKAKFMLHGGDYNPDQWLDRPDILADDIKLMKLS HTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTY PEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEY GGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGL HGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFA KHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNV NKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEV AKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTF WEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVN EHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTAS VEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVR HGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRI VVNTH*" /label="ganA CDS" gene complement(2919711..2921774) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /label="ganA gene" CDS complement(2921793..2922644) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17056685, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391294.1" /db_xref="EnsemblGenomes-Gn:BSU34140" /db_xref="EnsemblGenomes-Tr:CAB15419" /db_xref="GOA:O07011" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12438" /db_xref="UniProtKB/Swiss-Prot:O07011" /translation="MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNS LISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFS RFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNT YLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVL SSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGL TAGGTKG*" /label="ganQ CDS" gene complement(2921793..2922644) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /label="ganQ gene" CDS complement(2922648..2923904) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11160890, 15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 15849754, 16850406, 17056685, 27501980; Product type t : transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391295.1" /db_xref="EnsemblGenomes-Gn:BSU34150" /db_xref="EnsemblGenomes-Tr:CAB15420" /db_xref="GOA:O32261" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12437" /db_xref="UniProtKB/Swiss-Prot:O32261" /translation="MQHRQVALLLSIIPGLGQFYNKQWIKGIVFLFLGASFFAVFGDL LNMGFWGIFTLGTEVPRDNSVFLLAEGIIAVIVTCFGLAVYYVNLRDAFQSGKQRDEN KPLSSLKEQYQHIISEGYPYVVSGPSLFILIFAVIFPILFSFALAFTNYDLYHSPPAK LIDWVGFQTFANIFTVDIWRSTFFDVLAWTVVWTLAASTLQVTLGIFLAIIVNQKDLR FKRFFRTILILPWAVPGFVTILIFAGLFNDSFGAMNHDILAFFGIDPLPWMTDANWSR LALILMQGWLGFPYIFLVSTGVLQSIPDDLYEAATIDGASVFSKLRYITLPMVFIAMA PIIITQFTFNFNNFNIIYLFNGGGPAVTGSTAGGTDILVSWIYKLTMQSSQYSLAAAL TILLSVFVISIALWQFRQTKSFKEEA*" /label="ganP CDS" gene complement(2922648..2923904) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /label="ganP gene" CDS complement(2923944..2925209) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11682178, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="polygalactose / cyclodextrin-binding lipoprotein" /protein_id="NP_391296.1" /db_xref="EnsemblGenomes-Gn:BSU34160" /db_xref="EnsemblGenomes-Tr:CAB15421" /db_xref="GOA:O07009" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12436" /db_xref="UniProtKB/Swiss-Prot:O07009" /translation="MKMAKKCSVFMLCAAVSLSLAACGPKESSSAKSSSKGSELVVWE DKEKSNGIKDAVAAFEKEHDVKVKVVEKPYAKQIEDLRMDGPAGTGPDVLTMPGDQIG TAVTEGLLKELHVKKDVQSLYTDASIQSQMVDQKLYGLPKAVETTVLFYNKDLITEKE LPKTLEEWYDYSKKTADGSKFGFLALFDQIYYAESVMSGYGGYIFGKAKDGSYNPSDI GINNEGAVKGAALIQKFYKDGLFPAGIIGEQGINVLESLFTEGKAAAIISGPWNVEAF SNAGINYGITKLPKLENGKNMSSFIGVKSYNVSAFSKNEELAQELAVFLANEKNSKTR YEETKEVPAVKSLANDPAIMKSEAARAVTEQSRFSEPTPNIPEMNEIWTPADSALQTV ATGKADPKQALDQAAETAKGQIKAKHSGK*" /label="ganS CDS" gene complement(2923944..2925209) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /label="ganS gene" promotor_-10 complement(2925241..2925260) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2925263) /Source="Nicolas_upshifts" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2925275..2925282) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2925350..2926342) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 10486575, 17056685, 27501980, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 10486575, 17056685, 27501980, 28617843; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the galactan degradation operon (GanR / beta-1,4-galactobiose)" /protein_id="NP_391297.1" /db_xref="EnsemblGenomes-Gn:BSU34170" /db_xref="EnsemblGenomes-Tr:CAB15422" /db_xref="GOA:O07008" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12435" /db_xref="UniProtKB/Swiss-Prot:O07008" /translation="MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEK LNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADG IESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKT VNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFS VENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIS FAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN*" /label="ganR CDS" gene complement(2925350..2926342) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /label="ganR gene" downshifts complement(2925384) /Source="Nicolas_upshifts" /id="D1775" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="1.40325" /MaxDrop="2.80992" /score="14.7399792" /energy="-8.3" /TU="NA" /idTUdmin="U2694" /TUdmin=1111 /isTUend="FALSE" /label="downshifts" S_feature complement(2926472..2926521) /Source="Nicolas_S_feature" /locus_tag="new_3509781_3509830_c" /HighExp="Sw, BC, M0t90, M40t90, B60, Lbstat, Lbtran, S2, B36, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29208099999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1307" downshifts complement(2926495) /Source="Nicolas_upshifts" /id="D1776" /incds=0 /nref=88 /ntot=240 /MaxReadThrough="1.88481" /MaxDrop="5.0699" /score="7.28170345" /energy="-13.7" /TU="NA" /idTUdmin="U2694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2926522..2927181) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18604637, 24196425, 25031425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18604637, 24196425, 25031425; Product type r: regulator" /codon_start=1 /transl_table=11 /product="L-lactate utilization global transcriptional regulator (GntR family)" /protein_id="NP_391298.2" /db_xref="EnsemblGenomes-Gn:BSU34180" /db_xref="EnsemblGenomes-Tr:CAB15423" /db_xref="GOA:O07007" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12434" /db_xref="UniProtKB/Swiss-Prot:O07007" /translation="MIKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVE MKQGEGTYLKEFELNQISQPLSAALLMKKEDVKQLLEVRKLLEIGVASLAAEKRTEAD LERIQDALKEMGSIEADGELGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRE TRKIWLFSKKTSVQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVLSGYFEENV Q*" /label="lutR CDS" gene complement(2926522..2927181) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /label="lutR gene" S_feature complement(2927182..2927287) /Source="Nicolas_S_feature" /locus_tag="new_3510491_3510596_c" /HighExp="M0t90, Lbstat, BC, M40t90, Lbtran, Sw, S2, B60, ferm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69672000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1308" promotor_-10 complement(2927279..2927298) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2927288) /Source="Nicolas_upshifts" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2927313..2927316) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2927340..2927347 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2927362..2927381 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2927362 /Source="Nicolas_upshifts" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="upshifts" S_feature 2927365..2927470 /Source="Nicolas_S_feature" /locus_tag="new_3510674_3510779" /HighExp="T1.30H, S1, T1.0H, M40t90, T2.0H, M0t90, T3.0H, T2.30H, T0.30H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1309" promotor_-10 complement(2927371..2927388) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2927375) /Source="Nicolas_upshifts" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2927396..2927402) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2927471..2929162 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25031425; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_391299.1" /db_xref="EnsemblGenomes-Gn:BSU34190" /db_xref="EnsemblGenomes-Tr:CAB15424" /db_xref="GOA:P71067" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG11875" /db_xref="UniProtKB/Swiss-Prot:P71067" /translation="MQWTQAYTPIGGNLLLSALAALVPIIFFFWALAIKRMKGYTAGL ATLGIALIIAVLVYRMPAEKALMSATQGAVYGLLPIGWIIVTSVFLYKITVKTGQFDI IRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLVGLGFNPLYAAGIC LIANTAPVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLYLIIIMSGFR KALEIWPAILVSGVSFAVVQYLSSNFLGPELPDVLSALVSMAALAVFLKWWKPKTTFR FAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHY EGSAVFLKWLNAVGEKLTFSPGVPFLNNQIVNADGTPIEAVYKLEVLGSAGTAILIAA VLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTG KMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHVFSWMIP*" /label="lutP CDS" gene 2927471..2929162 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /label="lutP gene" downshifts 2929147 /Source="Nicolas_upshifts" /id="D1777" /incds=0 /nref=153 /ntot=245 /MaxReadThrough="4.82757" /MaxDrop="5.44233" /score="20.8815301" /energy="-11.7" /TU="NA" /idTUdmin="U2695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2929189..2930499) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11274109, 12533460, 12634342, 16166551, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 12533460, 12634342, 16166551, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-54 factor (sigma-L)" /protein_id="NP_391300.1" /db_xref="EnsemblGenomes-Gn:BSU34200" /db_xref="EnsemblGenomes-Tr:CAB15425" /db_xref="GOA:P24219" /db_xref="InterPro:IPR000394" /db_xref="InterPro:IPR007046" /db_xref="InterPro:IPR007634" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10748" /db_xref="UniProtKB/Swiss-Prot:P24219" /translation="MDMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLEN PLIERKETDTPPLSYHKTNKNRMNAQEAGLQLSNPQKTLQDALKQQSLDMNLTNTEKK IFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGARSLQECIL LQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPG LLFARPEQDVYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSY LSAKYQEWRWLSRALRQRKQTITRIINELITRQKDFFLKGRSAMKPLTLREVADCLSL HESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYAVKTHLENLINQEDKT KPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK*" /label="sigL CDS" gene complement(2929189..2930499) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /label="sigL gene" S_feature 2929192..2930262 /Source="Nicolas_S_feature" /locus_tag="new_3512501_3513571" /HighExp="M9-stat, T1.30H, S1, Sw, T1.0H, T2.0H, T0.30H, G/S, T3.30H, T2.30H" /AntisenseName="sigL" /AntisenseCor="0.63927172079726402" /AntisenseRegPval="-31.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1310" downshifts complement(2929201) /Source="Nicolas_upshifts" /id="D1778" /incds=0 /nref=62 /ntot=219 /MaxReadThrough="2.33779" /MaxDrop="5.56948" /score="28.2409666" /energy="-11.7" /TU="NA" /idTUdmin="U2698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2930319..2930338 /Source="Nicolas_upshift_promotors" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2930319..2930577 /Source="Nicolas_S_feature" /locus_tag="new_3513628_3513886" /HighExp="LBGstat, LBGexp, G180, Paraq, H2O2, LBGtran, Oxctl, Lbexp, dia0, HPh" /AntisenseName="sigL" /AntisenseCor="-0.50245218771496702" /AntisenseRegPval="-17.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1311" upshifts 2930319 /Source="Nicolas_upshifts" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2930513..2930532) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2930528) /Source="Nicolas_upshifts" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2930547..2930550) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2930578..2930796 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391301.1" /db_xref="EnsemblGenomes-Gn:BSU34210" /db_xref="EnsemblGenomes-Tr:CAB15426" /db_xref="InterPro:IPR018590" /db_xref="PDB:2GSV" /db_xref="PDB:2JS1" /db_xref="SubtiList:BG11876" /db_xref="UniProtKB/Swiss-Prot:P71066" /translation="MSELFSVPYFIENLKQHIEMNQSEDKIHAMNSYYRSVVSTLVQD QLTKNAVVLKRIQHLDEAYNKVKRGESK*" /label="yvfG CDS" gene 2930578..2930796 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /label="yvfG gene" downshifts 2930775 /Source="Nicolas_upshifts" /id="D1779" /incds=0 /nref=53 /ntot=250 /MaxReadThrough="3.27525" /MaxDrop="4.21929" /score="-0.306638574" /energy="-13.4" /TU="U2697" /idTUdmin="U2697" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" SCAR join(2930803,2930810) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs26" N_region 2930804..2930809 /note="EcoR site (GAATTC)" /created_by="User" /modified_by="User" /label="IIG_Bs26" promotor_-35 2930841..2930844 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2930850 /Source="Nicolas_upshifts" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2930861..2930879 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2930895..2932364 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7828905, 15138843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7828905, 15138843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="para-nitrobenzyl esterase (intracellular esterase B)" /protein_id="NP_391319.1" /db_xref="EnsemblGenomes-Gn:BSU34390" /db_xref="EnsemblGenomes-Tr:CAB15444" /db_xref="GOA:P37967" /db_xref="InterPro:IPR000997" /db_xref="InterPro:IPR002018" /db_xref="InterPro:IPR019819" /db_xref="InterPro:IPR019826" /db_xref="InterPro:IPR029058" /db_xref="PDB:1C7I" /db_xref="PDB:1C7J" /db_xref="PDB:1QE3" /db_xref="SubtiList:BG11844" /db_xref="UniProtKB/Swiss-Prot:P37967" /translation="MTHQIVTTQYGKVKGTTENGVHKWKGIPYAKPPVGQWRFKAPEP PEVWEDVLDATAYGSICPQPSDLLSLSYTELPRQSEDCLYVNVFAPDTPSKNLPVMVW IHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPFGFLHLSSFNEAYSDNLGLL DQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIAALLAMPAAKGLFQKAIMESGAS RTMTKEQAASTSAAFLQVLGINEGQLDKLHTVSAEDLLKAADQLRIAEKENIFQLFFQ PALDPKTLPEEPEKAIAEGAASGIPLLIGTTRDEGYLFFTPDSDVHSQETLDAALEYL LGKPLAEKVADLYPRSLESQIHMMTDLLFWRPAVAYASAQSHYAPVWMYRFDWHPKKP PYNKAFHALELPFVFGNLDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAV NWPAYHEETRETLILDSEITIENDPESEKRQKLFPSKGE*" /label="pnbA CDS" gene 2930895..2932364 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /label="pnbA gene" downshifts 2932341 /Source="Nicolas_upshifts" /id="D1780" /incds=0 /nref=4 /ntot=150 /MaxReadThrough="3.66738" /MaxDrop="2.70933" /score="-9.70074934" /energy="-12.2" /TU="U2703" /idTUdmin="U2703" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS 2932367..2932558 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514003.1" /translation="MGKTGYIGAAIVVAACIIILSAVVCLRDTVYYQPMRWTGIILFF AGIVMVPAYSAKRKPGKEK*" /label="hypothetical protein CDS" gene 2932367..2932558 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /label="gene" downshifts 2932537 /Source="Nicolas_upshifts" /id="D1781" /incds=0 /nref=24 /ntot=181 /MaxReadThrough="-0.096" /MaxDrop="4.20686" /score="34.8993337" /energy="-22.3" /TU="NA" /idTUdmin="U2703" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2932585..2933070) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /EC_number="4.1.1.102" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9546183, 12903944, 17295427, 18326577, 21685295, 26658822" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9546183, 12903944, 17295427, 18326577, 21685295, 26658822; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase" /protein_id="NP_391320.1" /db_xref="EnsemblGenomes-Gn:BSU34400" /db_xref="EnsemblGenomes-Tr:CAB15445" /db_xref="GOA:O07006" /db_xref="InterPro:IPR008729" /db_xref="InterPro:IPR012674" /db_xref="PDB:2P8G" /db_xref="PDB:4ALB" /db_xref="SubtiList:BG12433" /db_xref="UniProtKB/Swiss-Prot:O07006" /translation="MENFIGSHMIYTYENGWEYEIYIKNDHTIDYRIHSGMVAGRWVR DQEVNIVKLTEGVYKVSWTEPTGTDVSLNFMPNEKRMHGIIFFPKWVHEHPEITVCYQ NDHIDLMKESREKYETYPKYVVPEFAEITFLKNEGVDNEEVISKAPYEGMTDDIRAGR L*" /label="padC CDS" gene complement(2932585..2933070) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /label="padC gene" CDS complement(2933093..2933404) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="EnsemblGenomes-Gn:BSU34410" /db_xref="EnsemblGenomes-Tr:CAB15446" /db_xref="GOA:O07005" /db_xref="InterPro:IPR011250" /db_xref="InterPro:IPR020915" /db_xref="PSEUDO:CAB15446.2" /db_xref="SubtiList:BG12432" /db_xref="UniProtKB/Swiss-Prot:O07005" /translation="MPGGADSQMIRANGRTDLSARYVIETADHELIYIENNGIRQVSK PFRKQAAAGEIIEPEHVYFRTVPTFETGSEVYQWLHDRLFIGSAERTPDYVLLDIYEV Q*" /label="yveG CDS" gene complement(2933093..2933404) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /pseudo /label="yveG gene" CDS complement(2933456..2933548) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU34420" /db_xref="EnsemblGenomes-Tr:CAB15447" /db_xref="PSEUDO:CAB15447.1" /db_xref="SubtiList:BG12431" /db_xref="UniProtKB/Swiss-Prot:O07004" /translation="MKKPVLKPFASLEIKVDPPITIGETSLGLR*" /label="yveF CDS" gene complement(2933456..2933548) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /pseudo /label="yveF gene" promotor_-10 complement(2933588..2933607) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2933605) /Source="Nicolas_upshifts" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2933621..2933628) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2933679..2934362) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /EC_number="5.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9987136, 19063962, 2054383, 28894939" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 19063962, 2054383, 28894939; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aminoacid racemase (prefers arginine, lysine and ornithine)" /protein_id="NP_391323.1" /db_xref="EnsemblGenomes-Gn:BSU34430" /db_xref="EnsemblGenomes-Tr:CAB15448" /db_xref="GOA:P32960" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004380" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="SubtiList:BG10391" /db_xref="UniProtKB/Swiss-Prot:P32960" /translation="MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSC PTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLH IVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAI KQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKST VSTYLAYQS*" /label="racX CDS" gene complement(2933679..2934362) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /label="racX gene" downshifts complement(2933697) /Source="Nicolas_upshifts" /id="D1782" /incds=0 /nref=122 /ntot=223 /MaxReadThrough="3.49026" /MaxDrop="5.32077" /score="5.15607483" /energy="-9.3" /TU="U2705" /idTUdmin="U2704" /TUdmin="-708" /isTUend="FALSE" /label="downshifts" CDS complement(2934378..2935733) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7592498, 9987136, 12533473, 14679248, 19063962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592498, 9987136, 12533473, 14679248, 19063962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4*" /protein_id="NP_391324.1" /db_xref="EnsemblGenomes-Gn:BSU34440" /db_xref="EnsemblGenomes-Tr:CAB15449" /db_xref="GOA:P32959" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR021860" /db_xref="SubtiList:BG10390" /db_xref="UniProtKB/Swiss-Prot:P32959" /translation="MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAE MTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRH LLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVL LAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETY VLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRL NNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTE YEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTEN ERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRT K*" /label="pbpE CDS" gene complement(2934378..2935733) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /label="pbpE gene" promotor_-10 complement(2935745..2935760) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2935761) /Source="Nicolas_upshifts" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2935772..2935781) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2936035..2936042 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2936056..2936075 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2936059 /Source="Nicolas_upshifts" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="upshifts" S_feature 2936081..2936271 /Source="Nicolas_S_feature" /locus_tag="new_3535821_3536011" /HighExp="G150, G180, G135, LBGexp, Mt0, Lbexp, LBGtran, dia0, GM 150, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.219024" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1314" CDS 2936272..2937693 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /EC_number="2.4.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levansucrase; levanase (moonlighting)" /protein_id="NP_391325.1" /db_xref="EnsemblGenomes-Gn:BSU34450" /db_xref="EnsemblGenomes-Tr:CAB15450" /db_xref="GOA:P05655" /db_xref="InterPro:IPR003469" /db_xref="InterPro:IPR023296" /db_xref="PDB:1OYG" /db_xref="PDB:1PT2" /db_xref="PDB:2VDT" /db_xref="PDB:3BYJ" /db_xref="PDB:3BYK" /db_xref="PDB:3BYL" /db_xref="PDB:3BYN" /db_xref="SubtiList:BG10388" /db_xref="UniProtKB/Swiss-Prot:P05655" /translation="MNIKKFAKQATVLTFTTALLAGGATQAFAKETNQKPYKETYGIS HITRHDMLQIPEQQKNEKYQVPEFDSSTIKNISSAKGLDVWDSWPLQNADGTVANYHG YHIVFALAGDPKNADDTSIYMFYQKVGETSIDSWKNAGRVFKDSDKFDANDSILKDQT QEWSGSATFTSDGKIRLFYTDFSGKHYGKQTLTTAQVNVSASDSSLNINGVEDYKSIF DGDGKTYQNVQQFIDEGNYSSGDNHTLRDPHYVEDKGHKYLVFEANTGTEDGYQGEES LFNKAYYGKSTSFFRQESQKLLQSDKKRTAELANGALGMIELNDDYTLKKVMKPLIAS NTVTDEIERANVFKMNGKWYLFTDSRGSKMTIDGITSNDIYMLGYVSNSLTGPYKPLN KTGLVLKMDLDPNDVTFTYSHFAVPQAKGNNVVITSYMTNRGFYADKQSTFAPSFLLN IKGKKTSVVKDSILEQGQLTVNK*" /label="sacB CDS" gene 2936272..2937693 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /label="sacB gene" downshifts 2937687 /Source="Nicolas_upshifts" /id="D1783" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.33324" /MaxDrop="3.39023" /score="9.57663013" /energy="-7.7" /TU="NA" /idTUdmin="U2706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 2937767..2939317 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /EC_number="3.2.1.64" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11739774, 15528654, 26773563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11739774, 15528654, 26773563; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endolevanase, selectively cleaves the (beta-2,6)fructosyl bonds" /protein_id="NP_391326.1" /db_xref="EnsemblGenomes-Gn:BSU34460" /db_xref="EnsemblGenomes-Tr:CAB15451" /db_xref="GOA:O07003" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG12430" /db_xref="UniProtKB/Swiss-Prot:O07003" /translation="MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYR AAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEG VAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKG KSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYT SGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFK ADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGT DSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDT DLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPY DVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITV KHFDSIHE*" /label="levB CDS" gene 2937767..2939317 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /label="levB gene" promotor_-35 2939361..2939367 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2939381..2939392 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2939381 /Source="Nicolas_upshifts" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="upshifts" CDS 2939425..2940987 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12730183, 15528654, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12730183, 15528654, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-aspartate/L-glutamate / proton permease" /protein_id="NP_391327.1" /db_xref="EnsemblGenomes-Gn:BSU34470" /db_xref="EnsemblGenomes-Tr:CAB15452" /db_xref="GOA:O07002" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12429" /db_xref="UniProtKB/Swiss-Prot:O07002" /translation="MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSG AFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSL ISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANF IISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPI VSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSL PFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVN KDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKD LNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKED VSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKY TGLPKAAIDYDK*" /label="aspP CDS" gene 2939425..2940987 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /label="aspP gene" downshifts 2940965 /Source="Nicolas_upshifts" /id="D1784" /incds=0 /nref=12 /ntot=29 /MaxReadThrough="1.71122" /MaxDrop="3.47798" /score="-0.444529447" /energy="-11.7" /TU="NA" /idTUdmin="U2707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 2940977..2941666 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391328.2" /db_xref="EnsemblGenomes-Gn:BSU34480" /db_xref="EnsemblGenomes-Tr:CAB15453" /db_xref="GOA:O07001" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:2F07" /db_xref="SubtiList:BG12428" /db_xref="UniProtKB/Swiss-Prot:O07001" /translation="MINKEARGFLASLFFTNKHTRDKMNESQSLLEVFLMPKQTSGKY EKILQAAIEVISEKGLDKASISDIVKKAGTAQGTFYLYFSSKNALIPAIAENLLTHTL DQIKGRLHGDEDFWTVLDILIDETFLITERHKDIIVLCYSGLAIDHSMEKWETIYQPY YSWLEKIINKAIANHEVTEGINSKWTARTIINLVENTAERFYIGFEQDENVEVYKKEI FTFLKRSLGTA*" /label="yvdT CDS" gene 2940977..2941666 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /label="yvdT gene" promotor_-35 2941016..2941023 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2941037..2941056 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2941046 /Source="Nicolas_upshifts" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="upshifts" downshifts 2941647 /Source="Nicolas_upshifts" /id="D1785" /incds=0 /nref=189 /ntot=242 /MaxReadThrough="4.85194" /MaxDrop="4.84113" /score="-0.444529447" /energy="-11.7" /TU="U2708" /idTUdmin="U2707" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(2941745) /Source="Nicolas_upshifts" /id="D1786" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="0.8852" /MaxDrop="3.45447" /score="0.398849185" /energy="-11.7" /TU="NA" /idTUdmin="U2709" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS 2941748..2942083 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22978536; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium / proton antiporter subunit A" /protein_id="NP_391329.1" /db_xref="EnsemblGenomes-Gn:BSU34490" /db_xref="EnsemblGenomes-Tr:CAB15454" /db_xref="GOA:O32262" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12427" /db_xref="UniProtKB/Swiss-Prot:O32262" /translation="MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLI RSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKE SKSQPGGEK*" /label="psmA CDS" gene 2941748..2942083 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /label="psmA gene" CDS 2942083..2942403 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11160890, 22978536; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium-proton two component antiporter subunit" /protein_id="NP_391330.1" /db_xref="EnsemblGenomes-Gn:BSU34500" /db_xref="EnsemblGenomes-Tr:CAB15455" /db_xref="GOA:O06999" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12426" /db_xref="UniProtKB/Swiss-Prot:O06999" /translation="MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFY CLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRL TSSS*" /label="psmB CDS" gene 2942083..2942403 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /label="psmB gene" S_feature 2942404..2942594 /Source="Nicolas_S_feature" /locus_tag="new_3542144_3542334" /HighExp="Sw, BC, BI, Lbstat, M0t90, Lbtran, M40t90, H2O2, S8, Paraq" /AntisenseName="yvdQ" /AntisenseCor="3.5547360410813897E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1315" CDS complement(2942439..2942951) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391331.1" /db_xref="EnsemblGenomes-Gn:BSU34510" /db_xref="EnsemblGenomes-Tr:CAB15456" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR021617" /db_xref="SubtiList:BG12425" /db_xref="UniProtKB/Swiss-Prot:O06998" /translation="MGILSGNPQDEPMHYGEVFGLWSYVMAGNKMVGNYQMLLNHVGD DDLKKLLRESIEKCQDEIKQVSTILKENGVALPPASPEPPTADLNDIPPGARFLDPDV AASAAAENAAGLVTCSKMMGQSIREDIAMMFGQFHMSKAATGAKYLRLLKNKGWLIPP PLHLQKHHEA*" /label="yvdQ CDS" gene complement(2942439..2942951) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /label="yvdQ gene" downshifts 2942571 /Source="Nicolas_upshifts" /id="D1787" /incds=1 /nref=6 /ntot=39 /MaxReadThrough="1.61612" /MaxDrop="4.65362" /score="0.608596632" /energy="-14.2" /TU="NA" /idTUdmin="U2708" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2942987..2942998) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2942993) /Source="Nicolas_upshifts" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2943013..2943019) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2943066..2943202) /Source="Nicolas_S_feature" /locus_tag="new_3542806_3542942_c" /HighExp="BT, S7, S8, S6, B36, G/S, S5, Pyr, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1316" downshifts complement(2943109) /Source="Nicolas_upshifts" /id="D1788" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.38169" /MaxDrop="2.9968" /score="15.2862513" /energy="-10.3" /TU="U2710" /idTUdmin="U2709" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" CDS complement(2943203..2944546) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /EC_number="1.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat protein; putative oxidoreductase" /protein_id="NP_391332.1" /db_xref="EnsemblGenomes-Gn:BSU34520" /db_xref="EnsemblGenomes-Tr:CAB15457" /db_xref="GOA:O06997" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12424" /db_xref="UniProtKB/Swiss-Prot:O06997" /translation="MGSTQLTGRVIFKGDPGYTEAIKNWNPYVDVYPLVFVFAQNSYD VSNAIKWARENKVPLRVRSGRHALDKNLSVVSGGIVIDVSDMNKVFLDEENAIATVQT GIPVGPLVKGLARDGFMAPFGDSPTVGIGGITMGGGFGVLSRSIGLISDNLLALKTVD AKGRIIHADQSHNEDLLWASRGGGGGNFGYNTQYTFKVHRAPKTATVFNIIWPWEQLE TVFKAWQKWAPFVDERLGCYLEIYSKINGLCHAEGIFLGSKTELIRLLKPLLHAGTPT EADIKTLYYPDAIDFLDPDEPIPGRNDQSVKFSSAWGHDFWSDEPISIMRKFLEDATG TEANFFFINWGGAISRVPKDETAFFWRHPLFYTEWTASWKNKSQEDSNLASVERVRQL MQPYVAGSYVNVPDQNIENFGKEYYGANFARLREIKAKYDPENVFRFPQSIPPSR*" /label="cotNP CDS" gene complement(2943203..2944546) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /label="cotNP gene" promotor_-10 complement(2944575..2944594) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2944583) /Source="Nicolas_upshifts" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2944607..2944616) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2944608..2944613 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2944629..2944647 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2944632 /Source="Nicolas_upshifts" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2944841..2944850 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2944859 /Source="Nicolas_upshifts" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2944864..2944883 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2944902..2945864 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 20378985" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 20378985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat lipolytic enzyme" /protein_id="NP_391333.1" /db_xref="EnsemblGenomes-Gn:BSU34530" /db_xref="EnsemblGenomes-Tr:CAB15458" /db_xref="GOA:O06996" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG12423" /db_xref="UniProtKB/Swiss-Prot:O06996" /translation="MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNS IGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFP ADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPAT QRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWG MVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRF FRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK*" /label="cotR CDS" gene 2944902..2945864 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /label="cotR gene" S_feature 2945865..2946118 /Source="Nicolas_S_feature" /locus_tag="new_3545605_3545858" /HighExp="BT, S8, S7, B36, S6, Pyr, G/S, S3, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1317" downshifts complement(2946145) /Source="Nicolas_upshifts" /id="D1789" /incds=0 /nref=190 /ntot=241 /MaxReadThrough="3.19421" /MaxDrop="5.60739" /score="16.7489574" /energy="-13.2" /TU="U2713" /idTUdmin="U2713" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" tRNA complement(2946149..2946224) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA (CCG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnQ-Arg tRNA" gene complement(2946149..2946224) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /label="trnQ-Arg gene" promotor_-10 complement(2946251..2946270) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2946272) /Source="Nicolas_upshifts" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2946286..2946289) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2946355..2946361 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2946371..2946446 /Source="Nicolas_S_feature" /locus_tag="new_3546111_3546186" /HighExp="Salt, S3, S4, Etha, S5, LoTm, Gly, M9-stat, BT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1318" upshifts 2946371 /Source="Nicolas_upshifts" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2946376..2946395 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2946423..2946430 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2946444..2946463 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2946448 /Source="Nicolas_upshifts" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="upshifts" CDS 2946494..2947087 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /EC_number="3.4.21.92" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease proteolytic subunit; Maxwell's demon" /protein_id="NP_391334.1" /db_xref="EnsemblGenomes-Gn:BSU34540" /db_xref="EnsemblGenomes-Tr:CAB15459" /db_xref="GOA:P80244" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR018215" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR033135" /db_xref="PDB:3KTG" /db_xref="PDB:3KTH" /db_xref="PDB:3KTI" /db_xref="PDB:3KTJ" /db_xref="PDB:3KTK" /db_xref="PDB:3TT6" /db_xref="PDB:3TT7" /db_xref="SubtiList:BG19016" /db_xref="UniProtKB/Swiss-Prot:P80244" /translation="MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSI VSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAF LLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQ PLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK*" /label="clpP CDS" gene 2946494..2947087 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /label="clpP gene" downshifts 2947076 /Source="Nicolas_upshifts" /id="D1790" /incds=0 /nref=292 /ntot=300 /MaxReadThrough="4.45406" /MaxDrop="8.24306" /score="30.2626808" /energy="-14.6" /TU="U2714" /idTUdmin="U2715" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" S_feature 2947121..2947519 /Source="Nicolas_S_feature" /locus_tag="new_3546861_3547259" /HighExp="Etha, dia15, Heat, LoTm, M9-stat, Gly, dia5, Diami, S8, H2O2" /AntisenseName="pgcM" /AntisenseCor="0.13310786898312499" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1319" CDS complement(2947133..2947813) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /EC_number="2.7.1.41" /EC_number="5.4.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 11081794, 15996095" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 11081794, 15996095; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase" /protein_id="NP_391335.1" /db_xref="EnsemblGenomes-Gn:BSU34550" /db_xref="EnsemblGenomes-Tr:CAB15460" /db_xref="GOA:O06995" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR010972" /db_xref="InterPro:IPR010976" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3NAS" /db_xref="SubtiList:BG12422" /db_xref="UniProtKB/Swiss-Prot:O06995" /translation="MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKG ISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQ LKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDV SPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQ YRIRESIP*" /label="mdxM CDS" gene complement(2947133..2947813) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /label="mdxM gene" downshifts complement(2947157) /Source="Nicolas_upshifts" /id="D1791" /incds=0 /nref=2 /ntot=36 /MaxReadThrough="3.4944" /MaxDrop="3.50516" /score="-9.43329271" /energy="-14.6" /TU="U2718" /idTUdmin="U2718" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" CDS complement(2947810..2949495) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9573215, 10229946, 1670768" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573215, 10229946, 1670768; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase)" /protein_id="NP_391336.1" /db_xref="EnsemblGenomes-Gn:BSU34560" /db_xref="EnsemblGenomes-Tr:CAB15461" /db_xref="GOA:O06994" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="PDB:4M56" /db_xref="PDB:4M8U" /db_xref="PDB:4MAZ" /db_xref="PDB:4MB1" /db_xref="SubtiList:BG12421" /db_xref="UniProtKB/Swiss-Prot:O06994" /translation="MSEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGA DVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNH TSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYL HYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHS RSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELN MIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQP RVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKN AYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQD INVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLL VVVNLSEEKALFEAPPELIHERWKVLISNYPQERADLKSISLKPYEAVMGISI*" /label="mdxL CDS" gene complement(2947810..2949495) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /label="mdxL gene" CDS complement(2949488..2951761) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /EC_number="2.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16707683, 28527120" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 28527120; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose phosphorylase" /protein_id="NP_391337.1" /db_xref="EnsemblGenomes-Gn:BSU34570" /db_xref="EnsemblGenomes-Tr:CAB15462" /db_xref="GOA:O06993" /db_xref="InterPro:IPR005194" /db_xref="InterPro:IPR005195" /db_xref="InterPro:IPR005196" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR017045" /db_xref="SubtiList:BG12420" /db_xref="UniProtKB/Swiss-Prot:O06993" /translation="MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNF EEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKID LHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECL TGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTV LAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKE LLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDA RLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAA KLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGI DVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQS LESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELD PAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESS LSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGF AGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVY EEPVVLQGRCERRTPNE*" /label="mdxK CDS" gene complement(2949488..2951761) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /label="mdxK gene" CDS complement(2951739..2952623) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16707683, 16850406, 20436965; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative component of maltodextrin transporter" /protein_id="NP_391338.1" /db_xref="EnsemblGenomes-Gn:BSU34580" /db_xref="EnsemblGenomes-Tr:CAB15463" /db_xref="GOA:O06992" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG12419" /db_xref="UniProtKB/Swiss-Prot:O06992" /translation="MKNLENKSFIIRCLKAAASPSGVCRYGNTFSWLQLSFLFLFLTA CLMAPLAVSFVKMDRFSVSSFMPSAIQGVNDQFADQLQGFQIRNGKLTGGKSSERIED GQNVMAVDMKHEYETSGENGRLKVTGFENAIIFQPDQLVITDQNETGFSVGYAKMDVK LEKPNVHDVEVLIDTLWLAQYKPMIMMLAYTVVSMIQLLLTFVLAGGLWITKISNMVS IASFKEAASIAICASALPAFAAAAIGMVHFDLITVLMIHSCGVTLMISFAFRYLTKTR RDNGNLHSGGNDDKSAVI*" /label="mdxJ CDS" gene complement(2951739..2952623) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /label="mdxJ gene" CDS complement(2952629..2953465) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transporter (permease)" /protein_id="NP_391339.1" /db_xref="EnsemblGenomes-Gn:BSU34590" /db_xref="EnsemblGenomes-Tr:CAB15464" /db_xref="GOA:O06991" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12418" /db_xref="UniProtKB/Swiss-Prot:O06991" /translation="MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAA FQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFA GRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKG YFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLL RSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGT KG*" /label="mdxG CDS" gene complement(2952629..2953465) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /label="mdxG gene" CDS complement(2953466..2954773) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transport system (permease)" /protein_id="NP_391340.1" /db_xref="EnsemblGenomes-Gn:BSU34600" /db_xref="EnsemblGenomes-Tr:CAB15465" /db_xref="GOA:O06990" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12417" /db_xref="UniProtKB/Swiss-Prot:O06990" /translation="MNKHHTLTKQKRKAGLLSIIPGLGQIANQQLSKGLLFLAITGLF AFELCVFGIQALTGLMTLGSVPGEDHSLFMLIEGTLQLIVTMIFLMFYIFNIHDSRKT AAMKAAGLEVNTTAKDMICHAGDKGFPYLFTLPAYIMMVFVIIFPVLVTLFVALTNYD FYHIPPNRLIDWVGFKNFLNIFFLGSYRETFVNVLGWTVIWTICATTLQIILGIVTAL FVNQDFIKGKRIFRMIFLFPWAVPAFITIMSFSNMFNDSIGAVNAQVIPLFNHLPFVE LPAIAWKTDPFWTKTALIMIQTWLGFPYIYVMVTGVLQAIPGELYEAAKIDGATFIQR FRHITFPMILFATAPVMITQYTFNFNNFSIIYLFNEGGPGSAGAGAGSTDILISWIYK LTTGTSPQYSVAAAVTLLISFIVIGISLIAFKKSNAFGNEEVM*" /label="mdxF CDS" gene complement(2953466..2954773) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /label="mdxF gene" promotor_-35 2953831..2953840 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2953853..2953872 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2953857 /Source="Nicolas_upshifts" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2954813..2956066) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="maltose/maltodextrin-binding lipoprotein" /protein_id="NP_391341.1" /db_xref="EnsemblGenomes-Gn:BSU34610" /db_xref="EnsemblGenomes-Tr:CAB15466" /db_xref="GOA:O06989" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12416" /db_xref="UniProtKB/Swiss-Prot:O06989" /translation="MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEE TYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGL GQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFK DLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLN NKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEA KLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYED TNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASG KKSTQTSANDAVNVIKENIKEKYVK*" /label="mdxE CDS" gene complement(2954813..2956066) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /label="mdxE gene" S_feature complement(2956067..2956161) /Source="Nicolas_S_feature" /locus_tag="new_3555807_3555901_c" /HighExp="T1.0H, T0.30H, BC, T1.30H, M40t90, M0t90, BI, B60, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.804" /TUlongSig="NA" /TUlongPSig="NA" /label="S1320" CDS complement(2956162..2957931) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10825545, 15650689, 16707683, 19465663, 27871383, 27871383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10825545, 15650689, 16707683, 19465663, 27871383, 27871383; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maltogenic alpha-amylase" /protein_id="NP_391342.1" /db_xref="EnsemblGenomes-Gn:BSU34620" /db_xref="EnsemblGenomes-Tr:CAB15467" /db_xref="GOA:O06988" /db_xref="InterPro:IPR004185" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013777" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12415" /db_xref="UniProtKB/Swiss-Prot:O06988" /translation="MMEYAAIHHQPFSTDAYSYDGRTVHIKIRTKKGDADHIRFIWGD PYEYNDGKWSANEQPMRKIAATEMHDYWFAEVVPPFRRLQYAFVVTDDHEDIFFGSSG VCPYNEKTLETIHYYFKFPFVHEADTFQAPEWVKSTVWYQIFPERFANGREDLSPKNA LPWGSKDPDVNDFFGGDLQGIVDKLDYLEDLGVNGIYLTPIFSAPSNHKYDTLDYFSI DPHFGDPELFRTLVSQLHQRGMRIMLDAVFNHIGSASPQWQDVVKNGDQSRYKDWFHI HSFPVTDDNYDRFAFTADMPKLNTANPEVQKYLLDIALYWIREFDIDGWRLDVANEVD HVFWKTFRQAVSTEKPDVYILGEIWHSAEPWLRGDEFHAAMNYPFTEPMIEYFADQTI SASRMAHRVNAHLMNGMKQANEVMFNLLDSHDTKRLLTRCRNDEKKARALLAFMFAQT GSPCIYYGTEIGLNGENDPLCRKCMVWEKEKQNQDMLQFMKRLIALRKQENTLLTEGH LEWNLLDDKNDFISFSRTLDEKILIYFFNQGNVVQHVSLRELNIDRNKKICDAWTEQP LQHHDVIAVQPGEFLILSAAAPV*" /label="mdxD CDS" gene complement(2956162..2957931) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /label="mdxD gene" promotor_-35 2957852..2957857 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2957873..2957891 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2957883 /Source="Nicolas_upshifts" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2957969..2957988) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2957982) /Source="Nicolas_upshifts" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2958001..2958008) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2958044..2958994) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16707683, 23951303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 23951303; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the maltodextrin operon (LacI family)" /protein_id="NP_391343.1" /db_xref="EnsemblGenomes-Gn:BSU34630" /db_xref="EnsemblGenomes-Tr:CAB15468" /db_xref="GOA:O06987" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12414" /db_xref="UniProtKB/Swiss-Prot:O06987" /translation="MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELN YIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLLTGISRELDRNHYALQLVTRNS LNIGQCDGIIATGLRKNDFEGVIKAFEKPLVVFGQNEMGYDFIDVNNEKGTFMATRHV MGLGEREVVFFGIDLDEPFERAREQGYIRAMNKSFKKSNMFRIDNSSKKSECLARELL KSMDNQAAFVCASDRIALGVIRAAQSLGKRIPEDVAVTGNDGVFLDRISSPRLTTVRQ PVVEMGEACAKMLLKKMNEDGAAQGSLFFEPELIVRESTL*" /label="mdxR CDS" gene complement(2958044..2958994) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /label="mdxR gene" promotor_-10 complement(2959009..2959027) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2959022) /Source="Nicolas_upshifts" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2959039..2959047) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2959128) /Source="Nicolas_upshifts" /id="D1792" /incds=0 /nref=134 /ntot=243 /MaxReadThrough="0.22626" /MaxDrop="5.17193" /score="21.4455132" /energy="-10" /TU="NA" /idTUdmin="U2720" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2959200..2959775) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391344.1" /db_xref="EnsemblGenomes-Gn:BSU34640" /db_xref="EnsemblGenomes-Tr:CAB15469" /db_xref="InterPro:IPR005269" /db_xref="InterPro:IPR031100" /db_xref="PDB:1T35" /db_xref="SubtiList:BG12413" /db_xref="UniProtKB/Swiss-Prot:O06986" /translation="MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVG LMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFI SMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHL KLIHSSSRPDELIEQMQNYSYPILEKKWTEI*" /label="yvdD CDS" gene complement(2959200..2959775) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /label="yvdD gene" downshifts complement(2959212) /Source="Nicolas_upshifts" /id="D1793" /incds=0 /nref=30 /ntot=209 /MaxReadThrough="4.23893" /MaxDrop="3.6086" /score="21.4455132" /energy="-10" /TU="U2720" /idTUdmin="U2720" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2959818..2959837) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2959824..2959831 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2959834) /Source="Nicolas_upshifts" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="upshifts" upshifts 2959841 /Source="Nicolas_upshifts" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2959844..2959863 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2959852..2959859) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2959892..2960212 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16120674, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrophosphohydrolase" /protein_id="NP_391345.1" /db_xref="EnsemblGenomes-Gn:BSU34650" /db_xref="EnsemblGenomes-Tr:CAB15470" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011411" /db_xref="SubtiList:BG12412" /db_xref="UniProtKB/Swiss-Prot:O32263" /translation="MQLADAEKWMKEFYEKRGWTEYGPFIRVGFLMEEAGELARAVRA YEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLEDVMKAHQEKLTKR FEHA*" /label="yvdC CDS" gene 2959892..2960212 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /label="yvdC gene" downshifts 2960193 /Source="Nicolas_upshifts" /id="D1794" /incds=0 /nref=134 /ntot=247 /MaxReadThrough="2.19085" /MaxDrop="5.46819" /score="35.8658106" /energy="-11.6" /TU="NA" /idTUdmin="U2721" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2960239) /Source="Nicolas_upshifts" /id="D1795" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="0.462300000000001" /MaxDrop="6.90114" /score="30.4681035" /energy="-11.3" /TU="NA" /idTUdmin="U2722" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2960239..2961831) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion transporter" /protein_id="NP_391346.1" /db_xref="EnsemblGenomes-Gn:BSU34660" /db_xref="EnsemblGenomes-Tr:CAB15471" /db_xref="GOA:O06984" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12411" /db_xref="UniProtKB/Swiss-Prot:O06984" /translation="MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASGVEP EYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLENLLIAGFMAGVML VLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLRNVEKHENFHHNMFEI VQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTVVAVVFFPDRMATIG STYGEIPRHLPEFQFPELTLDKMVMLFPAALVIALLGGLESILSAMVADNMKGSKHDS NKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVSGVVHGVVVLLVLLVFA PYASHVPLASMAPILMVVAWNMSERKEVANMLRLKNADSFILAATFALTVLFDLIIGV ATGLLLAFVFFIRRMSEATRIHNQETHPVLAKREDPSVSMYAIEGPLFFGSIDSLESS LLEHVQKKPKTLILLMNKVHYMDTSAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLH KTGLFHKIGKQHFFDHHDEITG*" /label="yvdB CDS" gene complement(2960239..2961831) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /label="yvdB gene" CDS complement(2961850..2962443) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /EC_number="4.2.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10611359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carbonic anhydrase" /protein_id="NP_391347.1" /db_xref="EnsemblGenomes-Gn:BSU34670" /db_xref="EnsemblGenomes-Tr:CAB15472" /db_xref="GOA:O06983" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12410" /db_xref="UniProtKB/Swiss-Prot:O06983" /translation="MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDT RLTELLPQAMGLKNGDAKIVKNAGAIVSHPFGSVMRSILVAIYELQAEEVCIVGHHEC GMSGLNASSILEKAKERGVEDSCLNLLTSAGLDLKTWLTGFHSVEESVSHSVNMIKNH PLLPKKVPVHGLVIHPETGKLDVVINGYETELINNHS*" /label="yvdA CDS" gene complement(2961850..2962443) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /label="yvdA gene" promotor_-10 complement(2962485..2962504) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2962498) /Source="Nicolas_upshifts" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2962519..2962523) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2962569..2962574 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2962590..2962608 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2962591 /Source="Nicolas_upshifts" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2962764..2962771 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2962785..2962804 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2962789 /Source="Nicolas_upshifts" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" CDS 2962826..2963803 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /EC_number="1.1.1.215" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811658, 25769838; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-ketogluconate reductase; hydroxypyruvate / glyoxylate reductase" /protein_id="NP_391348.1" /db_xref="EnsemblGenomes-Gn:BSU34680" /db_xref="EnsemblGenomes-Tr:CAB15473" /db_xref="GOA:O32264" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12409" /db_xref="UniProtKB/Swiss-Prot:O32264" /translation="MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLK EAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTL DDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIG EQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP LLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ*" /label="yvcT CDS" gene 2962826..2963803 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /label="yvcT gene" downshifts 2963775 /Source="Nicolas_upshifts" /id="D1796" /incds=0 /nref=223 /ntot=269 /MaxReadThrough="2.44036" /MaxDrop="5.93476" /score="1.05732532" /energy="-14.7" /TU="NA" /idTUdmin="U2724" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2963841..2965781) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (permease)" /protein_id="NP_391349.1" /db_xref="EnsemblGenomes-Gn:BSU34690" /db_xref="EnsemblGenomes-Tr:CAB15474" /db_xref="GOA:O06981" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG12408" /db_xref="UniProtKB/Swiss-Prot:O06981" /translation="MNLRTIARKNILGNLQRYVAYFLSCVFAVSVFFVFTSFIFHPDV NEDNIYGGSLVKTCLSAALVVIIVFCIFFITYSNSAFLQARKKEFGLLTLFGTSKQQL RKMIYYEQSLISLAAIAAGIGAGLLFSKLFFMIMTWMLSVKVPISFAIVPKAFVMTIA GFLILFQTLLILSLGRIRKLEIIELIKSAKKPKSLPVYSKWLTVLSLLCLGSGYYLSA TANAIDMMFRVFPILILVLIGTYFFFTQSSVAFFRMLYRKKHSFYKGTNIIVRSNMIF RLKDHARMLFLTSVITAVILTATGVIYMFYSDLQRQEEQSIPQSVSWVEKDASRFQVM KPETAENTLKKAHAVITYKVDATGIPVTFQSDLPYGNKKMEAEALLISEKVYNQVAKE KGFPVIHLQENEAFINVSFQMMVKDTFGEGETAAFHMKSGKTLSYVMKKQQNKGILMS VDGVSRLLVVSEKSFDSLSQDVPLKEQMRMVGYELEHWQETVDVSEKLENMVPKEHTS DFQTRAPSYQIVKQGVALMLFIGLFVSVLFFIVQGSMLYLRMFTEIEDTGVQVLALKR IGVTDKEIHSILGKQIGFLFFIPFIAGTIHAGFAYAALSNMLNSNLFLEAVIVIFIYF VFQALYYIVTRHIYKRAVLQRM*" /label="psdB CDS" gene complement(2963841..2965781) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /label="psdB gene" downshifts complement(2963865) /Source="Nicolas_upshifts" /id="D1797" /incds=0 /nref=11 /ntot=187 /MaxReadThrough="0.26118" /MaxDrop="4.59213" /score="26.9028733" /energy="-14.7" /TU="NA" /idTUdmin="U2725" /TUdmin=34 /isTUend="FALSE" /label="downshifts" CDS complement(2965756..2966535) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12432961, 14651641, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (ATP-binding protein)" /protein_id="NP_391350.1" /db_xref="EnsemblGenomes-Gn:BSU34700" /db_xref="EnsemblGenomes-Tr:CAB15475" /db_xref="GOA:O06980" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12407" /db_xref="UniProtKB/Swiss-Prot:O06980" /translation="MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPS GSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTL TIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAI IHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFI KDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP*" /label="psdA CDS" gene complement(2965756..2966535) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /label="psdA gene" S_feature complement(2966536..2966617) /Source="Nicolas_S_feature" /locus_tag="new_3566276_3566357_c" /HighExp="LBGtran, M0t45, H2O2, C30, Lbexp, Lbstat, LBGstat, dia0, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1321" CDS complement(2966618..2967688) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [PsdR] response to lantibiotics (nisin and gallidermin)" /protein_id="NP_391351.1" /db_xref="EnsemblGenomes-Gn:BSU34710" /db_xref="EnsemblGenomes-Tr:CAB15476" /db_xref="GOA:O06979" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12406" /db_xref="UniProtKB/Swiss-Prot:O06979" /translation="MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMM YIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALW TKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSF PTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIK RRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETR LSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESK EGAGTVMTIVFSSDTLVNVTAL*" /label="psdS CDS" gene complement(2966618..2967688) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /label="psdS gene" CDS complement(2967682..2968395) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [PsdS] responding to lipid II-binding lantibiotics (nisin and gallidermin)" /protein_id="NP_391352.1" /db_xref="EnsemblGenomes-Gn:BSU34720" /db_xref="EnsemblGenomes-Tr:CAB15477" /db_xref="GOA:O06978" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12405" /db_xref="UniProtKB/Swiss-Prot:O06978" /translation="MYRILLVEDDERIASLLGGHLQKYGYEVKIAEQLNDIKLEFAEM KPDLVLLDINLPFFDGFYWCRQIRTISNAPIIFISARTDELNQVMAIENGGDDYITKP FHLEVVMAKIKSVLRRTYGEYSPSLPQESRIVELGGLTIYPDQNEAEWNSVRILFSQK EFQLLSIFVREHKKIVSRDELLEALWDDVDFVDDNTLTVNVNRLRRKLENAGLTDCIS TIRGQGYQFQVNRKDEAEC*" /label="psdR CDS" gene complement(2967682..2968395) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /label="psdR gene" promotor_-10 complement(2968441..2968460) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2968453) /Source="Nicolas_upshifts" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2968455..2968716) /Source="Nicolas_S_feature" /locus_tag="new_3568195_3568456_c" /HighExp="H2O2, G135, G180, Cold, Paraq, G150, dia15, Oxctl, LBGexp, C30" /AntisenseName="yvzJ" /AntisenseCor="0.56014644713727801" /AntisenseRegPval="-22.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1322" promotor_-35 complement(2968473..2968476) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2968476..2968483 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2968494..2968513 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2968499 /Source="Nicolas_upshifts" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2968542..2968751 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="YP_003097790.1" /db_xref="EnsemblGenomes-Gn:BSU34729" /db_xref="EnsemblGenomes-Tr:CAX52696" /db_xref="GOA:C0H3R7" /db_xref="UniProtKB/Swiss-Prot:C0H3R7" /translation="MKKIMLFLAMTSILSACQPNYTGKYIEIGDTLTDYTKECFKENE IPYKYEKGKLYIPEDAFDTAIYTCS*" /label="yvzJ CDS" gene 2968542..2968751 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /label="yvzJ gene" downshifts 2968729 /Source="Nicolas_upshifts" /id="D1798" /incds=0 /nref=7 /ntot=138 /MaxReadThrough="1.16039" /MaxDrop="3.61604" /score="-5.58790836" /energy="-11.4" /TU="NA" /idTUdmin="U2726" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2968761) /Source="Nicolas_upshifts" /id="D1799" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="3.16808" /MaxDrop="2.84175" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2968787..2969551) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10876241; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative arylamine N-acetyltransferase" /protein_id="NP_391353.1" /db_xref="EnsemblGenomes-Gn:BSU34730" /db_xref="EnsemblGenomes-Tr:CAB15478" /db_xref="GOA:O06977" /db_xref="InterPro:IPR001447" /db_xref="SubtiList:BG12404" /db_xref="UniProtKB/Swiss-Prot:O06977" /translation="MIKMSDFLKDCFQKIGWEKDHVSFGDLPLFLKAMAYRFPFENRA VLAKENYKITKEELWRRLLKDQHGGLCYDLNGFLYFVLREAGFHVKLIRGTVYAGDQE GWALEGTHAAVWLSAENGDYLVDIGFGINLALQPIPLSGETVQSPVGSFRIKKEETEK GSYVLLMDKGEGWQIGYAFTLEESDLGDLDNMKDIIHSHEKSPFNKSLLASKLTPSGR MVMSERHFTIYENGGNIQKSDIGPSGFEEKLNTHFL*" /label="yvcN CDS" gene complement(2968787..2969551) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /label="yvcN gene" downshifts complement(2968809) /Source="Nicolas_upshifts" /id="D1800" /incds=0 /nref=143 /ntot=253 /MaxReadThrough="3.19848" /MaxDrop="6.45069" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2969552..2969809) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="catabolite repression HPr-like protein" /protein_id="NP_391354.1" /db_xref="EnsemblGenomes-Gn:BSU34740" /db_xref="EnsemblGenomes-Tr:CAB15479" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1K1C" /db_xref="PDB:1MO1" /db_xref="PDB:1MU4" /db_xref="PDB:1ZVV" /db_xref="PDB:2AK7" /db_xref="PDB:2RLZ" /db_xref="SubtiList:BG12403" /db_xref="UniProtKB/Swiss-Prot:O06976" /translation="MVQQKVEVRLKTGLQARPAALFVQEANRFTSDVFLEKDGKKVNA KSIMGLMSLAVSTGTEVTLIAQGEDEQEALEKLAAYVQEEV*" /label="crh CDS" gene complement(2969552..2969809) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /label="crh gene" CDS complement(2969833..2970783) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10986251, 17603302, 19836336, 24097947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative morphogen" /protein_id="NP_391355.1" /db_xref="EnsemblGenomes-Gn:BSU34750" /db_xref="EnsemblGenomes-Tr:CAB15480" /db_xref="GOA:O06975" /db_xref="InterPro:IPR003802" /db_xref="InterPro:IPR018478" /db_xref="InterPro:IPR023054" /db_xref="InterPro:IPR027434" /db_xref="InterPro:IPR033981" /db_xref="SubtiList:BG12402" /db_xref="UniProtKB/Swiss-Prot:O06975" /translation="MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVL DVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKI LGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDS LCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRN SVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTL KELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK*" /label="whiA CDS" gene complement(2969833..2970783) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /label="whiA gene" CDS complement(2970806..2971759) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159; Product type f: factor" /codon_start=1 /transl_table=11 /product="gluconeogenesis morphogenetic factor (UDP-sugar binding)" /protein_id="NP_391356.2" /db_xref="EnsemblGenomes-Gn:BSU34760" /db_xref="EnsemblGenomes-Tr:CAB15481" /db_xref="GOA:O06974" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /db_xref="SubtiList:BG12401" /db_xref="UniProtKB/Swiss-Prot:O06974" /translation="MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSG RLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNI TGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVF LTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICN VMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFD IEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE*" /label="mgfK CDS" gene complement(2970806..2971759) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /label="mgfK gene" CDS complement(2971761..2972648) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /function="15.6: DNA transformation" /experiment="publication(s) with functional evidences, PMID:18334534, 19074378, 21179021, 21709426" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18334534, 19074378, 21179021, 21709426; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase possibly involved in regulator sRNA degradation" /protein_id="NP_391357.1" /db_xref="EnsemblGenomes-Gn:BSU34770" /db_xref="EnsemblGenomes-Tr:CAB15482" /db_xref="GOA:O06973" /db_xref="InterPro:IPR005337" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12400" /db_xref="UniProtKB/Swiss-Prot:O06973" /translation="MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSL LPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDS ILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIV KHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSS YVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYF KKDYYTHVTHRDIEKRSRK*" /label="yvcJ CDS" gene complement(2971761..2972648) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /label="yvcJ gene" CDS complement(2972673..2973149) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /EC_number="3.6.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative triphosphate pyrophosphate hydrolase" /protein_id="NP_391358.1" /db_xref="EnsemblGenomes-Gn:BSU34780" /db_xref="EnsemblGenomes-Tr:CAB15483" /db_xref="GOA:O06972" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG12399" /db_xref="UniProtKB/Swiss-Prot:O06972" /translation="MTYLQRVTNCVLQTDDKVLLLQKPRRGWWVAPGGKMESGESVRD SVIREYREETGIYIINPQLKGVFTFIIKDGDHIVSEWMMFTFVADSYTGQNVSESEEG KLQWHDVNDIQNLPMAPGDGHILDFMMKGQGLLHGTFTYTPEFELLSYRLDPQHIK*" /label="yvcI CDS" gene complement(2972673..2973149) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /label="yvcI gene" promotor_-10 complement(2973169..2973188) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2973183) /Source="Nicolas_upshifts" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2973204..2973208) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2973227..2973246) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2973240) /Source="Nicolas_upshifts" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2973261..2973264) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2973316..2973466) /Source="Nicolas_S_feature" /locus_tag="new_3573056_3573206_c" /HighExp="dia15, Diami, dia5, H2O2, Etha, LPhT, Cold, Paraq, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1323" downshifts complement(2973359) /Source="Nicolas_upshifts" /id="D1801" /incds=0 /nref=9 /ntot=78 /MaxReadThrough="6.94979" /MaxDrop="3.73811" /score="11.9453839" /energy="-11" /TU="U2729,U2733" /idTUdmin="U2734" /TUdmin=2904 /isTUend="FALSE" /label="downshifts" CDS complement(2973467..2974417) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /EC_number="1.8.1.9" /function="16.6: Maintain" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14597697, 15659166, 23813734, 24401092" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14597697, 15659166, 23813734, 24401092; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="NP_391359.1" /db_xref="EnsemblGenomes-Gn:BSU34790" /db_xref="EnsemblGenomes-Tr:CAB15484" /db_xref="GOA:P80880" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR005982" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12398" /db_xref="UniProtKB/Swiss-Prot:P80880" /translation="MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQM ANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKE YKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEE GVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVT LVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAA GDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK*" /label="trxB CDS" gene complement(2973467..2974417) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /label="trxB gene" S_feature complement(2974418..2974505) /Source="Nicolas_S_feature" /locus_tag="new_3574158_3574245_c" /HighExp="dia5, Diami, dia15, H2O2, Etha, Salt, Cold, Paraq, LPhT, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1324" promotor_-10 complement(2974494..2974513) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2974505) /Source="Nicolas_upshifts" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2974507..2974598) /Source="Nicolas_S_feature" /locus_tag="new_3574247_3574338_c" /HighExp="Cold, Oxctl, G180, G135, Paraq, C30, LBGexp, G150, S1, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1325" promotor_-35 complement(2974528..2974531) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2974546..2974552 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2974566..2974584 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2974580 /Source="Nicolas_upshifts" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="upshifts" S_feature 2974581..2977967 /Source="Nicolas_S_feature" /locus_tag="new_3574321_3577707" /HighExp="Sw, M9-stat, B60, T0.30H, Gly, BC, B36, T1.0H, Salt, C30" /AntisenseName="yvcD" /AntisenseCor="-0.261780844003138" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1326" CDS complement(2974623..2976044) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /EC_number="3.4.-.-" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted cell wall DL-endopeptidase" /protein_id="NP_391360.1" /db_xref="EnsemblGenomes-Gn:BSU34800" /db_xref="EnsemblGenomes-Tr:CAB15485" /db_xref="GOA:P40767" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG11023" /db_xref="UniProtKB/Swiss-Prot:P40767" /translation="MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQ SEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKK LKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSI VDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFD EAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKAS DETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGG TVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNL GPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGV SVDSMSNPYWKAAFKGVVRRVVQ*" /label="cwlO CDS" gene complement(2974623..2976044) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /label="cwlO gene" downshifts complement(2974643) /Source="Nicolas_upshifts" /id="D1802" /incds=0 /nref=8 /ntot=106 /MaxReadThrough="6.31311" /MaxDrop="3.4602" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1620 /isTUend="FALSE" /label="downshifts" downshifts complement(2974767) /Source="Nicolas_upshifts" /id="D1803" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="7.07718" /MaxDrop="2.13349" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" misc_feature 2975671..2975675 /Source="Nicolas_upshift_promotors" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2975681 /Source="Nicolas_upshifts" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2975960..2975964 /Source="Nicolas_upshift_promotors" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2975967 /Source="Nicolas_upshifts" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2976045..2976242) /Source="Nicolas_S_feature" /locus_tag="new_3575785_3575982_c" /HighExp="S1, Cold, T-3.40H, M9-exp, MG t5, MG 5, MG 15, T-5.40H, GM-0.2, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1327" downshifts 2976165 /Source="Nicolas_upshifts" /id="D1804" /incds=0 /nref=2 /ntot=119 /MaxReadThrough="6.41604" /MaxDrop="3.8522" /score="6.14322693" /energy="-7.6" /TU="U2730,U2731" /idTUdmin="U2731" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2976230..2976249) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-10" upshifts complement(2976242) /Source="Nicolas_upshifts" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" promotor_-35 complement(2976261..2976268) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-35" CDS complement(2976425..2977879) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391361.1" /db_xref="EnsemblGenomes-Gn:BSU34810" /db_xref="EnsemblGenomes-Tr:CAB15486" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12396" /db_xref="UniProtKB/Swiss-Prot:O06968" /translation="MGKHTSEHKNHAQIVQLLQDGQYFFHKGLKAYKERNLKRASKLI QRAVHLEPEDSEMLSQLAVIYSEMGQYQESNDLLDYIMANLEAEMPECHYFKANNFAH LGLFQEAYKEAAAYSDADPDGEFAEENDSLLDLLDLGDDGIEDSLYDQDELLVKQDRA KSLLESGQLAEAVAALEEITTEYPELWSAYNNLALAYFYSGNVVKAKQTAYEVLSHNE GNLHALCNLLVFYYYEREDEKVAELSDQLSNVYPMLLEQRYKLGATLALVGRYEIGYK WLKSLYKTGFEGDDTFFYWLSCSAYFTGHTDFAETIWRKVESQYPGEDRPAPWIERRE ALPSSVEQRLAAYYISSTKGETEHLEAVIRSKRITAPFETHFVKLLLNGDSAAADVSE DALFAYQTVKLLEQAEKEEMKTEVMSCWVFHVIQQIRAAAPLKNEKGWAAAICYIWKE AHGKQDTKKDTAARFGISPATLTKYMKYIDDILE*" /label="yvcD CDS" gene complement(2976425..2977879) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /label="yvcD gene" downshifts complement(2976445) /Source="Nicolas_upshifts" /id="D1805" /incds=0 /nref=11 /ntot=190 /MaxReadThrough="3.36188" /MaxDrop="3.98985" /score="16.3455178" /energy="-9.1" /TU="U2734" /idTUdmin="U2734" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" S_feature complement(2977880..2978004) /Source="Nicolas_S_feature" /locus_tag="new_3577620_3577744_c" /HighExp="LBGstat, Sw, Cold, BC, BI, Lbexp, dia0, G150, LBGtran, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1328" downshifts 2977925 /Source="Nicolas_upshifts" /id="D1806" /incds=0 /nref=4 /ntot=36 /MaxReadThrough="1.81602" /MaxDrop="3.41181" /score="7.59889121" /energy="-9.9" /TU="NA" /idTUdmin="U2730" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2978005..2979774) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16405427, 18215075, 21077936, 22711831, 24630999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16405427, 18215075, 21077936, 22711831, 24630999; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (ATP-binding and permease protein)" /protein_id="NP_391362.1" /db_xref="EnsemblGenomes-Gn:BSU34820" /db_xref="EnsemblGenomes-Tr:CAB15487" /db_xref="GOA:O06967" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12395" /db_xref="UniProtKB/Swiss-Prot:O06967" /translation="MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSL LIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLREL LWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILF IMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKA SNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSG ELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQI ENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYS PTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEK AAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSS LDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMAS HGLYRDFAEQQLKMNADLENKAG*" /label="bmrA CDS" gene complement(2978005..2979774) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /label="bmrA gene" S_feature complement(2979775..2979849) /Source="Nicolas_S_feature" /locus_tag="new_3579515_3579589_c" /HighExp="LBGstat, Cold, Lbexp, G150, Oxctl, dia0, T1.30H, T0.30H, BC, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1329" misc_feature complement(2979838..2979857) /Source="Nicolas_upshift_promotors" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2979849) /Source="Nicolas_upshifts" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" CDS complement(2979939..2980298) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391363.1" /db_xref="EnsemblGenomes-Gn:BSU34830" /db_xref="EnsemblGenomes-Tr:CAB15488" /db_xref="SubtiList:BG14157" /db_xref="UniProtKB/Swiss-Prot:O32265" /translation="MTSLFSESETEIVSTTYMFLTQDEMKGKAGTLNQPINDFLSLTK KFESSLKEEIKGQKGLIVKKIKKELESNSEKRKAALQMIKEEHTAKVDRYKMIIEDLR QQDVTLTYRKKKPVKDV*" /label="yvzA CDS" gene complement(2979939..2980298) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /label="yvzA gene" downshifts complement(2979959) /Source="Nicolas_upshifts" /id="D1807" /incds=0 /nref=146 /ntot=246 /MaxReadThrough="2.52417" /MaxDrop="4.81771" /score="18.5636016" /energy="-13.2" /TU="NA" /idTUdmin="U2735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2980313..2982223) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391364.1" /db_xref="EnsemblGenomes-Gn:BSU34840" /db_xref="EnsemblGenomes-Tr:CAB15489" /db_xref="SubtiList:BG12394" /db_xref="UniProtKB/Swiss-Prot:O06966" /translation="MGNKNVFENENVKLRLIDLEYDYKQKFASTIASEVKKAKKDFEA DIRRIYKEETHHDLPENMKIEIYTSNELVNQNTSIQSSTRESGYDGTAIHIIDEKKHI DQLQIISEGSADNKDWSYNFFGLFLGIDHSQYEATKEFTNKAKKAAGNSEDLKTFALG HSLANNNQVMVQLIDGEYDEVYGVNGAQVNIDQLLETDESLYRYVIRKFSYKYEDIDS IPPEKLKKEIQKYYEDKGVTTNITQRISKDDPLYGVSGKADFITFGDVKMADTNTSVK GIRNIMDGVPDEDVRSIQKFLQKYKDDYEKDGLNGFIKAASGIDIDLIEKVKNTDGAL KKVSVLYEHFDDVKQMYGRIKEELPSFLGFLHTLLRNSGPVVDQLAENGYIDETQKKV IKKELTNINASMRGIESRYEHFIDHLKHGQFMQALKDVGEIVDYVKSILSSLKTLDTE TKDALKLIVDGHSIVQMLNALSKEKGFSYKGSDIYFTGKSGSGETIQVNLSSAVRIYQ NGMKIVEDMEDAISKYQKVYSQEIDEDFIDKKQAIITAIHHMEENPSHYAFDLQFRLA AGFSHTFDKLEKISVHESFHTGALPANDGIVAELKKQTTEKRDFIKNIRESIEKLFEK EEMISQLFDFQS*" /label="yvcB CDS" gene complement(2980313..2982223) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /label="yvcB gene" CDS complement(2982225..2982767) /gene="yvcA" /locus_tag="PG10_pseudo_BSU_34850" /old_locus_tag="BSU_34850" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17590234; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391365.1" /db_xref="EnsemblGenomes-Gn:BSU34850" /db_xref="EnsemblGenomes-Tr:CAB15490" /db_xref="GOA:O06965" /db_xref="SubtiList:BG12393" /db_xref="UniProtKB/Swiss-Prot:O06965" /modified_by="User" /translation="MVSTKEEEPGYYLLESKLKGFRMLFPEDGKYLSRRSSLTGKNKE SIGFNSYDKDTNVMFDGHVTYYKEESFANEPKTMLDIVSGKNDYKGEYKKSSKKKTDI YTAKKKDIFDDIDRKYNYSYSYFGYVKSTEEDNLGVEYAFTLGCKNENQPCSLDEEKA KNKVEKLINSITFLIDKKEK*" /label="PG10_pseudo_BSU_34850" gene complement(2982225..2982767) /gene="yvcA" /locus_tag="PG10_pseudo_BSU_34850" /old_locus_tag="BSU_34850" /modified_by="User" /label="PG10_pseudo_BSU_34850" N_region 2982826..2983875 /comment="Inserted sequence is a combination of three independent chromosomal regions. First the arabinose inducible mtlA promoter, second a copy of the original comK gene as well as third a copy of the original comS gene." /modified_by="User" /label="IIG_Bs27_024" promotor_-35 2982886..2982893 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2982907..2982926 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2982912 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="upshifts" CDS 2982986..2983564 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" /label="comK CDS" gene 2982986..2983564 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /label="comK gene" CDS 2983613..2983753 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" /label="comS CDS" gene 2983613..2983753 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /label="comS gene" S_feature complement(<2983876..2983917) /Source="Nicolas_S_feature" /locus_tag="new_3582781_3582910_c" /HighExp="Etha, Diami, HiTm, T1.0H, Cold, MG 15, T0.30H, BMM, T1.30H, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1331" CDS complement(2983943..2984572) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15871048, 17767732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase" /protein_id="NP_391366.1" /db_xref="EnsemblGenomes-Gn:BSU34860" /db_xref="EnsemblGenomes-Tr:CAB15491" /db_xref="GOA:O34912" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="InterPro:IPR023019" /db_xref="InterPro:IPR026660" /db_xref="SubtiList:BG12603" /db_xref="UniProtKB/Swiss-Prot:O34912" /translation="MKQADELRFNEDGLIPAIVQDAASKEVLTLAYMNKESYEKTLET KETWFYSRSRQALWHKGETSGNTQAVKGIRYDCDQDALLVLVEPSGPACHTGSYSCFT KEQTEEQAADRFGIMNELERVIAERQAEMPEGAYTTYLFREGVDKILKKVGEEASEVI IAAKNRDHEELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE*" /label="hisIE CDS" gene complement(2983943..2984572) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /label="hisIE gene" downshifts complement(2983962) /Source="Nicolas_upshifts" /id="D1808" /incds=0 /nref=104 /ntot=178 /MaxReadThrough="4.37156" /MaxDrop="4.76747" /score="14.9565762" /energy="-8.4" /TU="U2738" /idTUdmin="U2735" /TUdmin="-3256" /isTUend="FALSE" /label="downshifts" CDS complement(2984569..2985327) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /EC_number="4.3.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 17767732, 19636909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase subunit" /protein_id="NP_391367.1" /db_xref="EnsemblGenomes-Gn:BSU34870" /db_xref="EnsemblGenomes-Tr:CAB15492" /db_xref="GOA:O34727" /db_xref="InterPro:IPR004651" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12600" /db_xref="UniProtKB/Swiss-Prot:O34727" /translation="MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGA DELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSV NTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAK EGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTK GEADAALAASIFHYKETSIKEVKSYLKEYGVNVR*" /label="hisF CDS" gene complement(2984569..2985327) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /label="hisF gene" CDS complement(2985324..2986061) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /EC_number="5.3.1.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 26294764; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /protein_id="NP_391368.1" /db_xref="EnsemblGenomes-Gn:BSU34880" /db_xref="EnsemblGenomes-Tr:CAB15493" /db_xref="GOA:O35006" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR006063" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023016" /db_xref="SubtiList:BG12597" /db_xref="UniProtKB/Swiss-Prot:O35006" /translation="MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEK EGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVER VILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELAN EGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADG VSGAIIGKALYTNQFTLSEALERVKRK*" /label="hisA CDS" gene complement(2985324..2986061) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /label="hisA gene" CDS complement(2986058..2986696) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /EC_number="2.4.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 15301532" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 15301532; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase, glutamineamidotransferase subunit" /protein_id="NP_391369.1" /db_xref="EnsemblGenomes-Gn:BSU34890" /db_xref="EnsemblGenomes-Tr:CAB15494" /db_xref="GOA:O34565" /db_xref="InterPro:IPR010139" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12602" /db_xref="UniProtKB/Swiss-Prot:O34565" /translation="MIGVIDYGMGNLYSVSKALERVGVPYFVSEKPEELKEADAFILP GVGSFGDAMDNLGYTKLDQLIHDMVSEGRLLLGICLGMQLLFEESEENGTASGLGLLK GKAVRLKAEDEKGNKLKVPHMGWNRLSFHNESPLLTKTEQGYAYFVHSYYIDGMEENA LLASADYGVRVPAVVGKRNVFGAQFHPEKSSTVGMSILTQFTKMAAEQKVKK*" /label="hisH CDS" gene complement(2986058..2986696) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /label="hisH gene" promotor_no_box 2986554..2986654 /Source="Nicolas_upshift_promotors" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2986614 /Source="Nicolas_upshifts" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2986697..2987281) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /EC_number="4.2.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 24311587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazoleglycerol-phosphate dehydratase [Mn(II)-dependent]" /protein_id="NP_391370.1" /db_xref="EnsemblGenomes-Gn:BSU34900" /db_xref="EnsemblGenomes-Tr:CAB15495" /db_xref="GOA:O34683" /db_xref="InterPro:IPR000807" /db_xref="InterPro:IPR020565" /db_xref="InterPro:IPR020568" /db_xref="SubtiList:BG12598" /db_xref="UniProtKB/Swiss-Prot:O34683" /translation="MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFT KHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEAL AQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML*" /label="hisB CDS" gene complement(2986697..2987281) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /label="hisB gene" CDS complement(2987278..2988561) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /EC_number="1.1.1.23" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10353847, 10353848, 21672513, 24140957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol dehydrogenase" /protein_id="NP_391371.1" /db_xref="EnsemblGenomes-Gn:BSU34910" /db_xref="EnsemblGenomes-Tr:CAB15496" /db_xref="GOA:O34651" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR022695" /db_xref="SubtiList:BG12599" /db_xref="UniProtKB/Swiss-Prot:O34651" /translation="MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAV RSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFY HRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREV FGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVS AEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALL GSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQ SAFEEHAESIAAFARLEGLEAHARSIEARERRISK*" /label="hisD CDS" gene complement(2987278..2988561) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /label="hisD gene" CDS complement(2988558..2989199) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /EC_number="2.4.2.17" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 14741209, 15660995, 17154531, 21774583, 22989207, 28092443, 28872824; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP phosphoribosyltransferase" /protein_id="NP_391372.1" /db_xref="EnsemblGenomes-Gn:BSU34920" /db_xref="EnsemblGenomes-Tr:CAB15497" /db_xref="GOA:O34520" /db_xref="InterPro:IPR001348" /db_xref="InterPro:IPR013820" /db_xref="InterPro:IPR018198" /db_xref="InterPro:IPR024893" /db_xref="PDB:2VD2" /db_xref="SubtiList:BG12601" /db_xref="UniProtKB/Swiss-Prot:O34520" /translation="MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVP EENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGL PNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK*" /label="hisG CDS" gene complement(2988558..2989199) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /label="hisG gene" CDS complement(2989192..2990367) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /EC_number="2.4.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 15660995; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase-like subunit of ATP phophoribosyltransferase" /protein_id="NP_391373.1" /db_xref="EnsemblGenomes-Gn:BSU34930" /db_xref="EnsemblGenomes-Tr:CAB15498" /db_xref="GOA:O34459" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR004517" /db_xref="InterPro:IPR006195" /db_xref="SubtiList:BG12606" /db_xref="UniProtKB/Swiss-Prot:O34459" /translation="MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPT LEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGY AANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIG HAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELR GGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGIL FEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVI FSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG* " /label="hisZ CDS" gene complement(2989192..2990367) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /label="hisZ gene" S_feature complement(2990368..2990445) /Source="Nicolas_S_feature" /locus_tag="new_3589361_3589438_c" /HighExp="Diami, M/G, Etha, BMM, MG 15, MG 10, T-1.10H, T-0.40H, T-1.40H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1332" promotor_-35 2990411..2990417 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2990429..2990448 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2990429..2990448) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2990442 /Source="Nicolas_upshifts" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2990445) /Source="Nicolas_upshifts" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2990461..2990468) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2990577..2990596 /Source="Nicolas_upshift_promotors" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2990584 /Source="Nicolas_upshifts" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="upshifts" CDS 2990618..2991370 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydratase" /protein_id="NP_391374.1" /db_xref="EnsemblGenomes-Gn:BSU34940" /db_xref="EnsemblGenomes-Tr:CAB15499" /db_xref="InterPro:IPR016997" /db_xref="SubtiList:BG14130" /db_xref="UniProtKB/Swiss-Prot:O34735" /translation="MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSD TDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLAN QVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSI SAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYL NDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK*" /label="yvpB CDS" gene 2990618..2991370 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /label="yvpB gene" S_feature 2991371..2991609 /Source="Nicolas_S_feature" /locus_tag="new_3590364_3590602" /HighExp="LBGstat, LPhT, Cold, Sw, M/G, G180, G135, LBGtran, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1333" promotor_-10 complement(2991392..2991403) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2991398) /Source="Nicolas_upshifts" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2991418..2991424) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2991610..2992275 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658655, 15187182, 16514142, 20000851, 24236123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658655, 15187182, 16514142, 20000851, 24236123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted pectate (polygalacturonate) lyase" /protein_id="NP_391375.1" /db_xref="EnsemblGenomes-Gn:BSU34950" /db_xref="EnsemblGenomes-Tr:CAB15500" /db_xref="GOA:O34310" /db_xref="InterPro:IPR004898" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG14129" /db_xref="UniProtKB/Swiss-Prot:O34310" /translation="MKKIVSILFMFGLVMGFSQFQPSTVFAADKVVHETIIVPKNTTY DGKGQRFVAGKELGDGSQSENQDPVFRVEDGATLKNVVLGAPAADGVHTYGNVNIQNV KWEDVGEDALTVKKEGKVTIDGGSAQKASDKIFQINKASTFTVKNFTADNGGKFIRQL GGSTFHVDVIIDKCTITNMKEAIFRTDSKTSTVRMTNTRYSNVGQKWIGVQHIYENNN TQF*" /label="pelC CDS" gene 2991610..2992275 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /label="pelC gene" downshifts 2992246 /Source="Nicolas_upshifts" /id="D1809" /incds=0 /nref=85 /ntot=213 /MaxReadThrough="1.40389" /MaxDrop="4.93342" /score="16.0973385" /energy="-14.9" /TU="NA" /idTUdmin="U2739" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(2992295..2992813) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21761520, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21761520, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphorylated heptaprenylglyceryl phosphate O-acetyltransferase" /protein_id="NP_391376.1" /db_xref="EnsemblGenomes-Gn:BSU34960" /db_xref="EnsemblGenomes-Tr:CAB15501" /db_xref="GOA:O34993" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG14128" /db_xref="UniProtKB/Swiss-Prot:O34993" /translation="MRKTDRHPVSGANSLWHVYQTVPFLKVVKNFIVIQIARYTPFIG MKNWLYRTFLRMKVGKQTSFALMVMPDIMFPEKISVGTNTIIGYNTTILAHEYLIHEY RIGKVLIGDEVMIGANTTILPGVKIGDGAVVSAGTLVHKDVPDGAFVGGNPMRIIYTK EEMQERLKKSAE*" /label="hprF CDS" gene complement(2992295..2992813) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /label="hprF gene" downshifts complement(2992329) /Source="Nicolas_upshifts" /id="D1810" /incds=0 /nref=245 /ntot=283 /MaxReadThrough="1.27998" /MaxDrop="6.44997" /score="38.2106579" /energy="-14.9" /TU="NA" /idTUdmin="U2741" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2992817..2993467) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /EC_number="3.6.1.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9465101, 12359880, 12411438, 16182622, 22353596" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9465101, 12359880, 12411438, 16182622, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Hpr-associated pyrophosphatase" /protein_id="NP_391377.1" /db_xref="EnsemblGenomes-Gn:BSU34970" /db_xref="EnsemblGenomes-Tr:CAB15502" /db_xref="GOA:Q9JMQ2" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023733" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14127" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ2" /translation="MSDKQVTTILFDLDGTLINTNELIIASFLHTLEHYYPSKYKRED VLAFIGPSLFDTFSSMDPDKCEDMIAMYRAYNHDMHDSLVTEYETVYETLDALKKAGF TLGIVTTKLRDTVNMGLKLTGIGEFFETVVTLDDVTNAKPDPEPVLLALKQLGSEPAE AIMVGDNYHDVLAGKNAGTKTAGVAWTIKGPEMLAKHEPDFMLEKMSDLLQIVGVK*" /label="ppaX CDS" gene complement(2992817..2993467) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /label="ppaX gene" CDS complement(2993464..2994402) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27226549; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with nucleotide binding domain" /protein_id="NP_391378.1" /db_xref="EnsemblGenomes-Gn:BSU34980" /db_xref="EnsemblGenomes-Tr:CAB15503" /db_xref="GOA:O34382" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG14126" /db_xref="UniProtKB/Swiss-Prot:O34382" /translation="MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVR LITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLI IESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWL GMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTS MTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIP VWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI*" /label="yvoD CDS" gene complement(2993464..2994402) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /label="yvoD gene" CDS complement(2994426..2995235) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /EC_number="2.4.99.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prelipoprotein diacylglycerol transferase" /protein_id="NP_391379.1" /db_xref="EnsemblGenomes-Gn:BSU34990" /db_xref="EnsemblGenomes-Tr:CAB15504" /db_xref="GOA:O34752" /db_xref="InterPro:IPR001640" /db_xref="SubtiList:BG12611" /db_xref="UniProtKB/Swiss-Prot:O34752" /translation="MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEK RGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIG AILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLH LPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIG RYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE*" /label="lgt CDS" gene complement(2994426..2995235) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /label="lgt gene" CDS complement(2995249..2996181) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /EC_number="2.7.4.-" /EC_number="2.7.11.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine protein kinase/phosphorylase (pyrophosphate-producing)" /protein_id="NP_391380.1" /db_xref="EnsemblGenomes-Gn:BSU35000" /db_xref="EnsemblGenomes-Tr:CAB15505" /db_xref="GOA:O34483" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG14125" /db_xref="UniProtKB/Swiss-Prot:O34483" /translation="MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYF TYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDAS EKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKS ETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAG AVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIE VAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE*" /label="hprK CDS" gene complement(2995249..2996181) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /label="hprK gene" promotor_-10 complement(2996223..2996242) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2996229) /Source="Nicolas_upshifts" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2996258..2996263) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2996298..2996305 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2996317 /Source="Nicolas_upshifts" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2996320..2996337 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2996363..2997553 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /EC_number="3.5.1.25" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6774970, 14557261, 21602348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6774970, 14557261, 21602348; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosamine-6-phosphate deacetylase" /protein_id="NP_391381.1" /db_xref="EnsemblGenomes-Gn:BSU35010" /db_xref="EnsemblGenomes-Tr:CAB15506" /db_xref="GOA:O34450" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2VHL" /db_xref="SubtiList:BG12630" /db_xref="UniProtKB/Swiss-Prot:O34450" /translation="MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYS KEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQ EHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVEL FKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGA SHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKL ILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNC SWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKE ADQI*" /label="nagA CDS" gene 2996363..2997553 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /label="nagA gene" promotor_-35 2997351..2997357 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2997372 /Source="Nicolas_upshifts" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2997373..2997391 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2997550..2998278 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /EC_number="3.5.99.6" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15755726, 18436239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 18436239; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate isomerase" /protein_id="NP_391382.1" /db_xref="EnsemblGenomes-Gn:BSU35020" /db_xref="EnsemblGenomes-Tr:CAB15507" /db_xref="GOA:O35000" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="PDB:2BKV" /db_xref="PDB:2BKX" /db_xref="SubtiList:BG12631" /db_xref="UniProtKB/Swiss-Prot:O35000" /translation="MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTY RQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIP NGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQ TRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDF PASALHLHSDVTVLIDREAASLRP*" /label="nagBA CDS" gene 2997550..2998278 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /label="nagBA gene" CDS 2998296..2999027 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /experiment="publication(s) with functional evidences, PMID:16207374, 20047956, 21602348, 23667565, 24673833, 26162881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 20047956, 21602348, 23667565, 24673833, 26162881; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_391383.1" /db_xref="EnsemblGenomes-Gn:BSU35030" /db_xref="EnsemblGenomes-Tr:CAB15508" /db_xref="GOA:O34817" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2WV0" /db_xref="PDB:4U0V" /db_xref="PDB:4U0W" /db_xref="PDB:4U0Y" /db_xref="PDB:4WWC" /db_xref="SubtiList:BG14124" /db_xref="UniProtKB/Swiss-Prot:O34817" /translation="MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQF GISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGS RLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNES HFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNG TAFEHAKSVYRGDRYTFVHYMDRLS*" /label="nagR CDS" gene 2998296..2999027 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /label="nagR gene" CDS complement(2999047..3002916) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_391384.1" /db_xref="EnsemblGenomes-Gn:BSU35040" /db_xref="EnsemblGenomes-Tr:CAB15509" /db_xref="GOA:O34986" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR011401" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036415" /db_xref="SubtiList:BG14123" /db_xref="UniProtKB/Swiss-Prot:O34986" /translation="MRKYTVIASILLSFLSVLSGGHHESKAFPVVQQELFQTPHYIPL LENPPQIDVKAEMRSNLMIEAQVRDNSYQAFSAFLFYKQSNELGYKMVPMDPTPGAVR KFLAQIPKRLIWNSELEYYIVMSNGKQRVESETKKLKLEGYQADLAHIPELLITELAV DTKNIGRADGYEFIEIFNTTDRTIDFKDYHIRYRYPKEGPDSDLIWRPDERILIPSGE TFVVWLKPAGHPELTSADFNRYYQTQLKEGKNLAVIDETEGMANTRPRAVVISTNTGK DISVAHYRKHALRRLSSVLYKYPLNGTAELLNISIGEKNPSPGTVLQAQVPDQKRKIK LDKEKPVIEDLTDRKPVRPAESIELRADIRDRSLVKTVAFYYRTDENKPFKRILAEKD RNDNLFHYIVYSPELIGKDQLEYYVAAGDGINEARTPVKMIDIKQTSKAHGLRMNIEN RDTLSGTQFLKATTEGRADSIKLWIDGKKQVTEPAMEKEVYFAFDTRKTNLYFKNAVT MEGKVLKVFDDTTNKYRTYSVPLPETLLRKGKQLQRITIRSGSKVSPFDTAENRDDFL VKNARLVLSDGTVIRDQRVSPEKELFIGDNQRSNKSWQFQFNLPDGLFTSQLLEWDTS KLSEGAHHIQASDGKENVSLVVRVDNSGPHIEPNITEGQTYKGNLILQADMYDKWSRI EEAEASLDGESITLPYHTSSSDLLPGKHSLKVTATDLAGNKTVIERIFKTEREHPDQP EVIDSEADTHKAKLSVRVKDPTNDAMDVGFYRGFQYTARNHVKIFKHASLTEPPKSFV PERETPFTNKELERVSAADGKTVSTENKELFPYHRFEVTVDPSIDENDLAESVWKGSS LPGRKVTMYAWNYRTNEWQPVDSFVAKDDKPFTLKASVIAADFVRESKMNVIVQDEIP PAKDMYTFVWMSDTQYYAESYPHIFDKQTEWIKDNQKQLNIKYVFHTGDIVDDSADIR QWKNADRSMSVLDKSGIPYGVLAGNHDVGHKDGSYRAFGKYFGSDRFDKKFHYGGSYK NNRGHYDLISSNGNDYIMLYMGWGITDEDIAWMNQVLKKHPDRMAILAFHEYLLVSGN RSPIGEKIFKEIVKPNPNVVMVLSGHYHSAMRKTDELDDDGDGKPDRLVHQMLADYQG GPEGGQGYLRLLQFDQANDMVHVSTYSPYVKDKNYYDTDTYGNKDEFSLSLDLKPRIK KVETDYFECNVYTNEELGKREQVKSGDTAEFRWDHLEPQSVYYWYIIVEDSFNGKTKS PIWKFKTKKETYRPAPDQFDFRHVSNP*" /label="yvnB CDS" gene complement(2999047..3002916) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /label="yvnB gene" downshifts complement(2999169) /Source="Nicolas_upshifts" /id="D1811" /incds=1 /nref=19 /ntot=109 /MaxReadThrough="1.28942" /MaxDrop="4.39575" /score="28.0438848" /energy="-16.5" /TU="NA" /idTUdmin="U2744" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3002936..3002947) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3002943) /Source="Nicolas_upshifts" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3002962..3002968) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3003006..3003012 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3003026..3003045 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3003031 /Source="Nicolas_upshifts" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="upshifts" CDS 3003081..3003554 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391385.1" /db_xref="EnsemblGenomes-Gn:BSU35050" /db_xref="EnsemblGenomes-Tr:CAB15510" /db_xref="GOA:O34692" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14122" /db_xref="UniProtKB/Swiss-Prot:O34692" /translation="MDNSIHDELFQAIQQFALKRDKRVWQKVQIPSIGISSQHHDHLK KDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNK KEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNEFSIDDLKTVTAFFNLWIKYM*" /label="yvnA CDS" gene 3003081..3003554 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /label="yvnA gene" S_feature 3003555..3003662 /Source="Nicolas_S_feature" /locus_tag="new_3602548_3602655" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, T2.30H, M9-stat, T2.0H, T1.30H, T1.0H, BC" /AntisenseName="cypX" /AntisenseCor="-1.1473096183385199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1334" CDS complement(3003595..3004812) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /EC_number="1.14.-.-" /function="16.5: Explore" /function="16.14: Store" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:4204912, 20690619, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 20690619, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclo-L-leucyl-L-leucyl dipeptide oxidase, pulcheriminic synthase" /protein_id="NP_391386.1" /db_xref="EnsemblGenomes-Gn:BSU35060" /db_xref="EnsemblGenomes-Tr:CAB15511" /db_xref="GOA:O34926" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR030904" /db_xref="InterPro:IPR036396" /db_xref="PDB:3NC3" /db_xref="PDB:3NC5" /db_xref="PDB:3NC6" /db_xref="PDB:3NC7" /db_xref="SubtiList:BG12580" /db_xref="UniProtKB/Swiss-Prot:O34926" /translation="MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT RGPVSLLVAFDGA*" /label="cypX CDS" gene complement(3003595..3004812) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /label="cypX gene" downshifts complement(3003608) /Source="Nicolas_upshifts" /id="D1812" /incds=0 /nref=11 /ntot=50 /MaxReadThrough="2.27112" /MaxDrop="6.67384" /score="-0.264310319" /energy="-11.6" /TU="NA" /idTUdmin="U2747" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3003634..3003639 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3003654..3003665 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3003664..3003949 /Source="Nicolas_S_feature" /locus_tag="new_3602657_3602942" /HighExp="BC, Sw, Lbstat, T5.0H, M9-stat, T4.0H, T3.30H, B60, T1.30H, T0.30H" /AntisenseName="cypX" /AntisenseCor="-4.04991056466339E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.438, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1335" upshifts 3003664 /Source="Nicolas_upshifts" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="upshifts" downshifts 3003906 /Source="Nicolas_upshifts" /id="D1813" /incds=1 /nref=9 /ntot=165 /MaxReadThrough="3.27492" /MaxDrop="3.99509" /score="54.0406126" /energy="-11.4" /TU="U2745,U2746" /idTUdmin="U2746" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3004828..3005574) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /EC_number="6.-.-.-" /function="16.14: Store" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:4204912, 19430487, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 19430487, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclodipeptide synthase (tRNA-dependent), pulcherimminic acid precursor" /protein_id="NP_391387.1" /db_xref="EnsemblGenomes-Gn:BSU35070" /db_xref="EnsemblGenomes-Tr:CAB15512" /db_xref="GOA:O34351" /db_xref="InterPro:IPR030903" /db_xref="SubtiList:BG14121" /db_xref="UniProtKB/Swiss-Prot:O34351" /translation="MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFS EDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAER ALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRAR GVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHE FSICMRPNQGYLIVQEMAQMLSEKRITSEG*" /label="pchC CDS" gene complement(3004828..3005574) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /label="pchC gene" S_feature complement(3005575..3005761) /Source="Nicolas_S_feature" /locus_tag="new_3604568_3604754_c" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T3.0H, T1.0H, B36, BT, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1336" promotor_-10 complement(3005747..3005766) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3005761) /Source="Nicolas_upshifts" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3005780..3005787) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3005895..3005902 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3005917..3005936 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3005929 /Source="Nicolas_upshifts" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="upshifts" S_feature 3005930..3005999 /Source="Nicolas_S_feature" /locus_tag="new_3604923_3604992" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T1.0H, T0.30H, B36, T3.0H, BT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1337" CDS 3006000..3006509 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27542896; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for pulcherriminic acid synthesis" /protein_id="NP_391388.1" /db_xref="EnsemblGenomes-Gn:BSU35080" /db_xref="EnsemblGenomes-Tr:CAB15513" /db_xref="GOA:P40762" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11018" /db_xref="UniProtKB/Swiss-Prot:P40762" /translation="MSDLTKQMIYDIYVRLLHLNEQKANTSLQQFFKEAAEEDVAEIP KNMTSIHVIDCIGQHEPINNAGIARKMNLSKANVTKISTKLIKEEFINSYQLTDNKKE VYFKLTRKGRRIFDLHEKLHKKKELAFYQFLDSFSQEEQKAVLKFLEQLTSTLEAEQT DGTPDKPVK*" /label="pchR CDS" gene 3006000..3006509 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /label="pchR gene" S_feature complement(3006405..3007743) /Source="Nicolas_S_feature" /locus_tag="new_3605398_3606736_c" /HighExp="T0.30H, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, G135, T2.30H, T-1.10H, G180" /AntisenseName="yvmA" /AntisenseCor="0.2423954904641" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1338" downshifts complement(3006446) /Source="Nicolas_upshifts" /id="D1814" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.42525" /MaxDrop="2.72496" /score="14.1278884" /energy="-7.8" /TU="NA" /idTUdmin="U2749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3006530..3007741 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27542896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pulcherriminic acid efflux transporter" /protein_id="NP_391389.1" /db_xref="EnsemblGenomes-Gn:BSU35090" /db_xref="EnsemblGenomes-Tr:CAB15514" /db_xref="GOA:O34307" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14120" /db_xref="UniProtKB/Swiss-Prot:O34307" /translation="MAHTKSKAVLILYTVCFSAFFASLSQNIYSPILPIIKESFHVST AMVNLSVSVFMIVTAIMQIILGAIIDFKGARIVLITGILATAAASIGCAVTTDFTLFL IFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLSVAPAIAPVLGGFIGGA AGYEGIFWILAAISIVLLVTNSITFPKDSPTESMQQAKGNVFAHYKSIFTNRTGNVIL TLSFVLFFIYFAVIVYLPILLTEHYHIDVGIAGLLYLPLALSTIAGTFLFKRIQAKIG LHTLFIGSNVIAACSIILFAVTHSVSLVLMALTLALFGISMGVIPPLYSTMITNEFEH NRGSAIGMFNFIRYTGMAAGPMVSAYLLTMMPSAMSFSLLGLGFAALSFCLLPPMFSP QKRTKQKKHHM*" /label="pchE CDS" gene 3006530..3007741 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /label="pchE gene" downshifts 3007739 /Source="Nicolas_upshifts" /id="D1815" /incds=0 /nref=33 /ntot=196 /MaxReadThrough="5.27186" /MaxDrop="4.73361" /score="54.0406126" /energy="-11.4" /TU="U2748" /idTUdmin="U2748" /TUdmin="-721" /isTUend="FALSE" /label="downshifts" CDS complement(3007769..3008128) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26296725; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral phage holin-like membrane protein" /protein_id="NP_391390.1" /db_xref="EnsemblGenomes-Gn:BSU35100" /db_xref="EnsemblGenomes-Tr:CAB15515" /db_xref="GOA:O34648" /db_xref="InterPro:IPR007165" /db_xref="SubtiList:BG14119" /db_xref="UniProtKB/Swiss-Prot:O34648" /translation="MVKWAVSILVNALLLIVIDGYIDSIHISSIGAAIIASLILSILN VLIKPLLIIFTLPVTMVTLGLFLFVINAITLMMTASIMGDSFQIDGFGTAIWASVILS VFHLLIQKGILEPLRKK*" /label="yvlD CDS" gene complement(3007769..3008128) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /label="yvlD gene" S_feature 3007784..3008500 /Source="Nicolas_S_feature" /locus_tag="new_3606777_3607493" /HighExp="LBGstat, S8, Gly, C30, G135, S7, C90, Sw, Fru, S6" /AntisenseName="yvlC" /AntisenseCor="0.178445666283919" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1339" downshifts complement(3007788) /Source="Nicolas_upshifts" /id="D1816" /incds=0 /nref=129 /ntot=265 /MaxReadThrough="4.63835" /MaxDrop="5.15146" /score="14.4434545" /energy="-9.6" /TU="U2749" /idTUdmin="U2751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3008130..3008327) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23980836; Product type r : regulator" /codon_start=1 /transl_table=11 /product="membrane associated phage-like stress regulator,nisin resistance" /protein_id="NP_391391.1" /db_xref="EnsemblGenomes-Gn:BSU35110" /db_xref="EnsemblGenomes-Tr:CAB15516" /db_xref="GOA:O34719" /db_xref="InterPro:IPR007168" /db_xref="SubtiList:BG14118" /db_xref="UniProtKB/Swiss-Prot:O34719" /translation="MNKLYRSEKNKKIAGVIGGLAEYFNWDASLLRVITVILAIMTSV LPVLLIYIIWIFIVPSERDMK*" /label="yvlC CDS" gene complement(3008130..3008327) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /label="yvlC gene" CDS complement(3008332..3009429) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function, stress-related" /protein_id="NP_391392.1" /db_xref="EnsemblGenomes-Gn:BSU35120" /db_xref="EnsemblGenomes-Tr:CAB15517" /db_xref="InterPro:IPR016599" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14117" /db_xref="UniProtKB/Swiss-Prot:O34628" /translation="MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALS VHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQF KDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKG NKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSF SYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINV TESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKE MMFTSNQAHDQNITVFSESLTGAIKLKYSQR*" /label="yvlB CDS" gene complement(3008332..3009429) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /label="yvlB gene" CDS complement(3009454..3009780) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391393.1" /db_xref="EnsemblGenomes-Gn:BSU35130" /db_xref="EnsemblGenomes-Tr:CAB15518" /db_xref="GOA:O34322" /db_xref="SubtiList:BG14116" /db_xref="UniProtKB/Swiss-Prot:O34322" /translation="MNRNQAIIASLCYFSVFIAPIIVPIVAYFVVNEKETKRHAIRSL ISHIVPFVGWLFLFIALLGGAVAIDGDSLLPVFVIIGGAVIYFLVVIGIIIWNVIQGI KVLRAA*" /label="yvlA CDS" gene complement(3009454..3009780) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /label="yvlA gene" promotor_-10 complement(3009833..3009848) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3009848) /Source="Nicolas_upshifts" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3009850..3010340) /Source="Nicolas_S_feature" /locus_tag="new_3608843_3609333_c" /HighExp="H2O2, G180, Paraq, G150, G135, dia15, Oxctl, Diami, Lbexp, LBGexp" /AntisenseName="yvkN" /AntisenseCor="0.37678416921083902" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1340" promotor_-35 complement(3009860..3009869) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3009928..3009931 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3009946..3009965 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3009956 /Source="Nicolas_upshifts" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="upshifts" CDS 3009998..3010228 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391394.1" /db_xref="EnsemblGenomes-Gn:BSU35140" /db_xref="EnsemblGenomes-Tr:CAB15519" /db_xref="SubtiList:BG14115" /db_xref="UniProtKB/Swiss-Prot:O34604" /translation="MEKDPSDYTVTQESVLKLIQEQKRMNREMITELEQIHGPFPISH DIQYIKVLLDSSNTHIVQDLMSVSKQLYKKTL*" /label="yvkN CDS" gene 3009998..3010228 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /label="yvkN gene" promotor_-10 complement(3010331..3010350) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-10" upshifts complement(3010341) /Source="Nicolas_upshifts" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="upshifts" promotor_-35 complement(3010366..3010370) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-35" CDS complement(3010427..3010909) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16936039; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="putative flagellin" /db_xref="EnsemblGenomes-Gn:BSU35150" /db_xref="EnsemblGenomes-Tr:CAB15520" /db_xref="GOA:O34366" /db_xref="InterPro:IPR001029" /db_xref="PSEUDO:CAB15520.1" /db_xref="SubtiList:BG14158" /db_xref="UniProtKB/Swiss-Prot:O34366" /translation="MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLT VNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTI NNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR *" /label="yvzB CDS" gene complement(3010427..3010909) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /pseudo /label="yvzB gene" downshifts 3010435 /Source="Nicolas_upshifts" /id="D1817" /incds=0 /nref=13 /ntot=113 /MaxReadThrough="0.9814" /MaxDrop="4.76969" /score="2.6592903" /energy="-5.7" /TU="NA" /idTUdmin="U2750" /TUdmin=17 /isTUend="TRUE" /label="downshifts" downshifts complement(3010450) /Source="Nicolas_upshifts" /id="D1818" /incds=0 /nref=118 /ntot=206 /MaxReadThrough="2.62918" /MaxDrop="8.97968" /score="25.6132739" /energy="-19.8" /TU="NA" /idTUdmin="U2752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3010582) /Source="Nicolas_upshifts" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3010590..3010593) /Source="Nicolas_upshift_promotors" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3010670..3010674) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3010670) /Source="Nicolas_upshifts" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3010690..3010693) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3010910..3011043) /Source="Nicolas_S_feature" /locus_tag="new_3609903_3610036_c" /HighExp="H2O2, Sw, M40t45, M40t90, Diami, Salt, dia15, BC, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1341" CDS complement(3011071..3013944) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit A)" /protein_id="NP_391396.1" /db_xref="EnsemblGenomes-Gn:BSU35160" /db_xref="EnsemblGenomes-Tr:CAB15533" /db_xref="GOA:O34863" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004602" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12697" /db_xref="UniProtKB/Swiss-Prot:O34863" /translation="MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAF DTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT VTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGR KGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAAR LSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGAC PTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDV PVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDF IREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSE KDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGV LYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGI HGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKK VNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDK VIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEA CRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFF ENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDE PTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIV ASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS*" /label="uvrA CDS" gene complement(3011071..3013944) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /label="uvrA gene" downshifts complement(3011088) /Source="Nicolas_upshifts" /id="D1819" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="4.46283" /MaxDrop="5.3695" /score="12.0157254" /energy="-18.6" /TU="U2754,U2756" /idTUdmin="U2755" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3013952..3015937) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="NP_391397.1" /db_xref="EnsemblGenomes-Gn:BSU35170" /db_xref="EnsemblGenomes-Tr:CAB15534" /db_xref="GOA:P37954" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004807" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR024759" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036876" /db_xref="PDB:2D7D" /db_xref="PDB:2NMV" /db_xref="PDB:3V4R" /db_xref="SubtiList:BG10502" /db_xref="UniProtKB/Swiss-Prot:P37954" /translation="MKDRFELVSKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTG KTFTVSNLIKEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYV PQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEEYREMVVS LRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIFPASRDEHCVRVEFFG DEIERIREVDALTGEILGDRDHVAIFPASHFVTRAEKMEKAIQNIEKELEEQLKVMHE NGKLLEAQRLEQRTRYDLEMMREMGFCSGIENYSRHLTLRPPGSTPYTLLDYFPDDFM IVVDESHVTIPQVRGMFNGDQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYV SATPGPYEIEHTDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLV TTLTKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGINLLREG LDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYADKITKSMEIAINE TKRRREQQERFNEEHGITPKTINKEIRDVIRATVAAEDKAEYKTKAAPKLSKMTKKER QKVVEQMEHEMKEAAKALDFERAAELRDLLLELKAEG*" /label="uvrB CDS" gene complement(3013952..3015937) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /label="uvrB gene" promotor_-10 complement(3015971..3015990) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3015983) /Source="Nicolas_upshifts" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3015985..3016070) /Source="Nicolas_S_feature" /locus_tag="new_3614978_3615063_c" /HighExp="Gly, Sw, B60, BT, LoTm, Salt, Etha, M9-stat, B36, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1342" promotor_-35 complement(3016002..3016009) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3016115) /Source="Nicolas_upshifts" /id="D1820" /incds=0 /nref=4 /ntot=60 /MaxReadThrough="5.68784" /MaxDrop="3.17938" /score="11.285993" /energy="-12" /TU="U2755,U2756" /idTUdmin="U2755" /TUdmin="-5027" /isTUend="FALSE" /label="downshifts" CDS complement(3016123..3016353) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 1592822, 1744042; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_391398.1" /db_xref="EnsemblGenomes-Gn:BSU35180" /db_xref="EnsemblGenomes-Tr:CAB15535" /db_xref="GOA:P37953" /db_xref="InterPro:IPR019242" /db_xref="SubtiList:BG10501" /db_xref="UniProtKB/Swiss-Prot:P37953" /translation="MITKAVFALFFPFMLVVLFTRVTFNHYVAIALTAALLFASYLKG YTETYFIVGLDVVSLVAGGLYMAKKAAEKKEE*" /label="csbA CDS" gene complement(3016123..3016353) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /label="csbA gene" promotor_-10 complement(3016380..3016399) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-10" upshifts complement(3016390) /Source="Nicolas_upshifts" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="upshifts" S_feature complement(3016392..3016456) /Source="Nicolas_S_feature" /locus_tag="new_3615385_3615449_c" /HighExp="Gly, M9-stat, B60, Sw, Etha, LoTm, BT, B36, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1343" promotor_-35 complement(3016413..3016420) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-35" promotor_-10 complement(3016433..3016451) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3016454) /Source="Nicolas_upshifts" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3016466..3016472) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3016522) /Source="Nicolas_upshifts" /id="D1821" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.9693" /MaxDrop="4.37808" /score="-1.92287727" /energy="-4.2" /TU="NA" /idTUdmin="U2761" /TUdmin=4752 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(3016548..3016648) /Source="Nicolas_upshift_promotors" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3016588) /Source="Nicolas_upshifts" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3016670..3016677 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3016691..3016710 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3016708 /Source="Nicolas_upshifts" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3016800..3019295 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /EC_number="2.7.-.-" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25012659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_391399.1" /db_xref="EnsemblGenomes-Gn:BSU35190" /db_xref="EnsemblGenomes-Tr:CAB15536" /db_xref="GOA:O34796" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG14114" /db_xref="UniProtKB/Swiss-Prot:O34796" /translation="MYSVLFRQAEESSQLAGAKGMNLIKLTKHGLPVPDGFIIQTNAL ARFMEDNQLQETSENVEGGIISGTFSDELKDELTSSFYKLRESYRSVAVRSSSASEDL EGASFAGQYETYLNIKTEEEFLAKVKECWASFFSGRVSSYKKKMNNQIAEPLMGIVVQ GLIDSEMSGVIFSRNPVTHDDRELLISASYGLGEAVVSGNVTPDTFIVNKSSFEIQKE IGAKEIYMESAAEGIAEKETSEDMRSRFCLTDEQVIELAEITKKTEDLYGYPVDIEFG IADHQIYLLQARPITTIDQDKKAAEEKRSFMITDTDMNDFWLNMESNIEGPVSPLFSS FIVPALEYGLKKSMQKFPIGVVVDEVKLYRGHIYSKNQGGQQPPSEDCGKELFPILSE HMYDIINHTYLPFYRTLDQLAQTEHTAESALEAFQKLKAFYLTAYEEHFNIVFPQILL TNKLQAMYQDIQGESENAHFYEMLTGKMNKSLETDRCLWLFSVEVQENPNLLAIFENN KPEQLQEKLEQTDEGRHFLKNVHEFLQEYGWRSVKSHDLIEQIWVENPYFALANIQNY VRNGYHFDNEFQKTKEKREKLYNEFLESIEDPGLRTEFDRYYQWTLNSANIKDDHHFY IDAMLDAKARIFLLKIGELLAENGVIQDREDLWFLYDDEVEQALLHPVSLQEKAEKRR QIFHEYELAQAPAYLGTPTKEQLKAAEEIVGAVIEDEKNTENHIFGIAASSGIATGPV KIIRDANEFSQFAPGDVLVCKMTTPLWTSLFQDAKAIITDTGGILSHAAIIAREYGIP AVLGTRTATERLRDGDIITVDGSSGKITVVSRS*" /label="yvkC CDS" gene 3016800..3019295 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /label="yvkC gene" misc_feature 3019310..3019314 /Source="Nicolas_upshift_promotors" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3019328 /Source="Nicolas_upshifts" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="upshifts" CDS 3019371..3019940 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391400.1" /db_xref="EnsemblGenomes-Gn:BSU35200" /db_xref="EnsemblGenomes-Tr:CAB15537" /db_xref="GOA:O34643" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG14113" /db_xref="UniProtKB/Swiss-Prot:O34643" /translation="MRPTNKRILDAAMQLLVKKGYRATTTKEIAEKANVSEATIFRNF KNKQGLVEALLSQHSSNRGSILEQTEGDLYKDLLHIGTCLLEELEHRKDIIKISFREP AMFQDVINHVTEYPQSMKQLLVDYLKTMGEKGVIQTGNEAEHADVFMSIIFGYFIHRL HLGDRVISMPQEKMLEHSTALFVKGISAD*" /label="yvkB CDS" gene 3019371..3019940 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /label="yvkB gene" CDS 3019971..3021305 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391401.1" /db_xref="EnsemblGenomes-Gn:BSU35210" /db_xref="EnsemblGenomes-Tr:CAB15538" /db_xref="GOA:O34502" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14112" /db_xref="UniProtKB/Swiss-Prot:O34502" /translation="MSSRKEWALIVSLLLGAILVPINSTMIAVALSSISHTYNESIAS ITWVVTVYLIVMAVTQPIAGKLGDMYGNKTMYLWGVGLFLIASLGCALSPSLLLLIVF RALQAVGGALLTPNSIAIIRHVVSEKRLPKVFGFFGLGAGLGAALGPFIGSILIDSFS WHSIFWVNIPFLAIALFTALTMFPQYKENKSDAPLDIIGSLLLAGSIVSIILLTKNEA PWGYTVYSVLILLFVPLFFRREKRTQHPIIDFALFKSSTFTNANLSVLLSNLMMYAVL LIMPLFMTNQFGLNTSNSGMALSVFSIFMSASNWVGAQLHHKWGAKKIIFLSFAMMAG ANLLFLLLSSSHSVLFLMLSLILGGLASGVGLTSMQVSSLATVDPGMSGVASGIFSTF RYFGSIISSALIGLISGYHTLFMILFAVSIIGVFVSLGIKSDETARIEKNSA*" /label="yvkA CDS" gene 3019971..3021305 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /label="yvkA gene" downshifts 3021286 /Source="Nicolas_upshifts" /id="D1822" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="0.94661" /MaxDrop="3.57731" /score="21.0606505" /energy="-28.8" /TU="NA" /idTUdmin="U2759" /TUdmin=1276 /isTUend="FALSE" /label="downshifts" CDS complement(3021353..3022546) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16030230, 16850406, 18976281, 19019154, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16030230, 16850406, 18976281, 19019154, 26735940; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="topological determinant of cell division" /protein_id="NP_391402.1" /db_xref="EnsemblGenomes-Gn:BSU35220" /db_xref="EnsemblGenomes-Tr:CAB15539" /db_xref="GOA:O34375" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14111" /db_xref="UniProtKB/Swiss-Prot:O34375" /translation="MSVQWGIELLKSAGLFFLHPLFWFFIIITLAFGYVRIKRERKTF HTRIADIYDDLKFTYTKGLIPGLLLSVILGGLGISIPLGLLAIIAVITAAAAFTLRAN WMSAAYIVSVSMLIGFGLQIYQAEPFLERFPQGFAVVWPAVAVFLGLLIITEGAVAYR SAHVRTSPALVVSSRGLPIGQQLANRVWLLPLFLLVPGNGLESHLSWWPVFTVPGGSF HFLWIPYFVGFGQRVQGSLPETSIRITAKRVCILGLAVAVLGAASLLWTPLAGAAVCT ALLGRIFLSIKQRVNDNAAPFYFSKRDQGLMVLGIIPNTPAEDLELKIGEIITKVNGI PVKNVSDFYEALQHNRAYVKLEIIGLNGEIRFDQRASYEGEHHELGILFVKDDREDEA VASGS*" /label="minJ CDS" gene complement(3021353..3022546) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /label="minJ gene" downshifts complement(3021362) /Source="Nicolas_upshifts" /id="D1823" /incds=0 /nref=3 /ntot=85 /MaxReadThrough="3.18641" /MaxDrop="3.13207" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=66 /isTUend="FALSE" /label="downshifts" downshifts complement(3021427) /Source="Nicolas_upshifts" /id="D1824" /incds=1 /nref=94 /ntot=239 /MaxReadThrough="4.11808" /MaxDrop="4.31508" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(3022547..3022624) /Source="Nicolas_S_feature" /locus_tag="new_3621540_3621617_c" /HighExp="LBGstat, Lbstat, M0t90, Cold, M/G, GM 10, GM 25, GM 15, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1344" downshifts complement(3022550) /Source="Nicolas_upshifts" /id="D1825" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="6.36185" /MaxDrop="3.35962" /score="-9.46264764" /energy="-7.1" /TU="U2760,U2761,U2762" /idTUdmin="U2762" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(3022625..3022963) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16030230" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein fragment; C-terminal part of swrAA" /db_xref="GOA:O32266" /db_xref="InterPro:IPR035388" /db_xref="PSEUDO:CAB15540.1" /db_xref="SubtiList:BG14160" /db_xref="UniProtKB/Swiss-Prot:O32266" /translation="MCVKKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTN VESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLS NVTLWMTQER*" /label="swrAAc CDS" gene complement(3022625..3022963) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /pseudo /label="swrAAc gene" CDS complement(3022938..3023054) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein; N-terminal part of swrAA" /db_xref="PSEUDO:CAX52697.1" /translation="MLVSTPVLLLILARAYLYKENGGSQLKRASIVREKKIL*" /label="swrAAn CDS" gene complement(3022938..3023054) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /pseudo /label="swrAAn gene" S_feature complement(3023055..3023144) /Source="Nicolas_S_feature" /locus_tag="new_3622048_3622137_c" /HighExp="LBGstat, M0t90, Cold, Lbstat, GM 25, Gly, nit, GM 15, GM 10, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1345" promotor_-10 complement(3023126..3023144) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3023144) /Source="Nicolas_upshifts" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3023146..3023226) /Source="Nicolas_S_feature" /locus_tag="new_3622139_3622219_c" /HighExp="LBGstat, Lbstat, Cold, M0t90, GM 25, nit, Gly, M/G, MG 150, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigGF" /TUshortPSig="0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1346" promotor_-35 complement(3023158..3023163) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3023212..3023230) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3023226) /Source="Nicolas_upshifts" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3023244..3023251) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3023363..3024805) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14526016, 17557826, 27342562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526016, 17557826, 27342562; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="PDZ-containing carboxyl-terminal protease processing protease [Zn(II)]" /protein_id="NP_391404.1" /db_xref="EnsemblGenomes-Gn:BSU35240" /db_xref="EnsemblGenomes-Tr:CAB15541" /db_xref="GOA:O35002" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="PDB:4C2C" /db_xref="PDB:4C2D" /db_xref="PDB:4C2E" /db_xref="PDB:4C2F" /db_xref="PDB:4C2G" /db_xref="PDB:4C2H" /db_xref="SubtiList:BG14110" /db_xref="UniProtKB/Swiss-Prot:O35002" /translation="MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQA DSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQ FSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDL NHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIA ISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQ IAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGK GTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPL KVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTA ETLNQQIEKKKSDEKNDLQLQTALKSLFVN*" /label="ctpB CDS" gene complement(3023363..3024805) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /label="ctpB gene" downshifts complement(3023452) /Source="Nicolas_upshifts" /id="D1826" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="3.56833" /MaxDrop="3.1636" /score="0.562448109" /energy="-11.6" /TU="U2762" /idTUdmin="U2762" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3024851..3024862) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3024862) /Source="Nicolas_upshifts" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3024877..3024883) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3024945..3025835) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 23855774, 23869552" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 23855774, 23869552; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-division ABC transporter" /protein_id="NP_391405.1" /db_xref="EnsemblGenomes-Gn:BSU35250" /db_xref="EnsemblGenomes-Tr:CAB15542" /db_xref="GOA:O34876" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR004513" /db_xref="SubtiList:BG12591" /db_xref="UniProtKB/Swiss-Prot:O34876" /translation="MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIM LNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLV DSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSR LFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWP FFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIA IGAVIGVWGSLTSIRKFLRV*" /label="ftsX CDS" gene complement(3024945..3025835) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /label="ftsX gene" downshifts complement(3024962) /Source="Nicolas_upshifts" /id="D1827" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="3.3693" /MaxDrop="6.15417" /score="15.3496791" /energy="-14.6" /TU="U2763" /idTUdmin="U2763" /TUdmin="-102" /isTUend="FALSE" /label="downshifts" CDS complement(3025828..3026514) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division signal transducer (ATP-binding protein)" /protein_id="NP_391406.1" /db_xref="EnsemblGenomes-Gn:BSU35260" /db_xref="EnsemblGenomes-Tr:CAB15543" /db_xref="GOA:O34814" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12590" /db_xref="UniProtKB/Swiss-Prot:O34814" /translation="MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTF IKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAF ALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVI ADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRD ESRGEYGSYD*" /label="ftsE CDS" gene complement(3025828..3026514) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /label="ftsE gene" S_feature complement(3026515..3026647) /Source="Nicolas_S_feature" /locus_tag="new_3625508_3625640_c" /HighExp="Cold, UNK1, MG-0.2, MG 15, MG-0.1, C30, MG 25, MG 10, M9-exp, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.998" /label="S1347" promotor_-10 complement(3026637..3026656) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3026647) /Source="Nicolas_upshifts" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3026671..3026674) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3026748..3027086) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10473570, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10473570, 19222757; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome c551" /protein_id="NP_391407.1" /db_xref="EnsemblGenomes-Gn:BSU35270" /db_xref="EnsemblGenomes-Tr:CAB15544" /db_xref="GOA:O34594" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG12574" /db_xref="UniProtKB/Swiss-Prot:O34594" /translation="MKSKLSILMIGFALSVLLAACGSNDAKEEKTDTGSKTEATASEG EELYQQSCVGCHGKDLEGVSGPNLQEVGGKYDEHKIESIIKNGRGNMPKGLVDDNEAA VIAKWLSEKK*" /label="cccB CDS" gene complement(3026748..3027086) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /label="cccB gene" downshifts complement(3026749) /Source="Nicolas_upshifts" /id="D1828" /incds=0 /nref=192 /ntot=265 /MaxReadThrough="3.58546" /MaxDrop="6.88513" /score="18.0901387" /energy="-16.8" /TU="U2764" /idTUdmin="U2765" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3027113..3027132) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3027126) /Source="Nicolas_upshifts" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" CDS complement(3027135..3028019) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10473570, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391408.2" /db_xref="EnsemblGenomes-Gn:BSU35280" /db_xref="EnsemblGenomes-Tr:CAB15545" /db_xref="GOA:O34792" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG14109" /db_xref="UniProtKB/Swiss-Prot:O34792" /translation="MLSESIGRNGGYMMDVRNKTLWILRDYVYILIGAAITAVSFNVF LLPNKIAAGGVSGISTILQSYGFEAAYVQWIINIPLFIAGVILLGGKFGLKTLAGSVF LPLVVFLTRDIQPATHHELLAAIFGGVGIGIGIGIVYLGKGSTGGTALAAQIIHKYSG LSLGKCLAIIDGMIVVTAMIVFNIEQGLYAMLGVYVSSKTIDVVQVGFNRSKMALIIT KQEQAVKEAVLQKIDRGVTKISAVGGYTDDDRPILMCVVGQTEFTKLKQIVKQIDESA FVIVADASEVLGEGFKRA*" /label="yvjA CDS" gene complement(3027135..3028019) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /label="yvjA gene" promotor_-35 complement(3027146..3027153) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" promotor_-10 complement(3028007..3028026) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3028028) /Source="Nicolas_upshifts" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" promotor_-35 complement(3028041..3028048) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" CDS join(complement(3029176..3029247), complement(3028146..3029174)) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /experiment="publication(s) with functional evidences, PMID:1408743, 9696765, 9882663" /ribosomal_slippage /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1408743, 9696765, 9882663; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="NP_391409.1" /db_xref="EnsemblGenomes-Gn:BSU35290" /db_xref="EnsemblGenomes-Tr:CAB15546" /db_xref="GOA:P28367" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /db_xref="InterPro:IPR020853" /db_xref="SubtiList:BG10742" /db_xref="UniProtKB/Swiss-Prot:P28367" /translation="MELSEIRAELENMASRLADFRGSLDLESKEARIAELDEQMADPE FWNDQQKAQTVINEANGLKDYVNSYKKLNESHEELQMTHDLLKEEPDTDLQLELEKEL KSLTKEFNEFELQLLLSEPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWGERRGF KVETLDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS CEVMPEFNDEIDIDIRTEDIKVDTYRASGAGGQHVNTTDSAVRITHLPTNVVVTCQTE RSQIKNRERAMKMLKAKLYQRRIEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSMVK DHRTNTEMGNVQAVMDGDIDTFIDAYLRSKLS*" /label="prfB CDS" gene complement(3028146..3029247) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /label="prfB gene" downshifts complement(3028162) /Source="Nicolas_upshifts" /id="D1829" /incds=0 /nref=193 /ntot=257 /MaxReadThrough="2.78016" /MaxDrop="6.41678" /score="27.1588259" /energy="-9.8" /TU="NA" /idTUdmin="U2766" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(3029248..3029316) /Source="Nicolas_S_feature" /locus_tag="new_3628241_3628309_c" /HighExp="Etha, Sw, Cold, BC, G150, BI, dia15, Mt0, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1348" CDS complement(3029317..3031842) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="translocase binding subunit (ATPase)" /protein_id="NP_391410.1" /db_xref="EnsemblGenomes-Gn:BSU35300" /db_xref="EnsemblGenomes-Tr:CAB15547" /db_xref="GOA:P28366" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR020937" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036266" /db_xref="InterPro:IPR036670" /db_xref="PDB:1M6N" /db_xref="PDB:1M74" /db_xref="PDB:1TF2" /db_xref="PDB:1TF5" /db_xref="PDB:2IBM" /db_xref="PDB:3DL8" /db_xref="PDB:3IQM" /db_xref="PDB:3IQY" /db_xref="PDB:3JV2" /db_xref="PDB:5EUL" /db_xref="SubtiList:BG10741" /db_xref="UniProtKB/Swiss-Prot:P28366" /translation="MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHK TIEFKERLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKT GEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMS KDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSILIDEAR TPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTEEGMTKAEKAFGID NLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLH QAIEAKEGLEIQNESMTLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTI PTNRPVVRDDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVV GTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDS TPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVIDSENLR EIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINTTYLDEGALEKSDIFGKEPD EMLELIMDRIITKYNEKEEQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHL RAYAQTNPLREYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQ PQEGDDNKKAKKAPVRKVVDIGRNAPCHCGSGKKYKNCCGRTE*" /label="secA CDS" gene complement(3029317..3031842) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /label="secA gene" S_feature complement(3031843..3031923) /Source="Nicolas_S_feature" /locus_tag="new_3630836_3630916_c" /HighExp="Etha, M9-stat, T0.30H, B60, dia5, Cold, dia15, Lbexp, Salt, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1349" misc_feature complement(3031913..3031932) /Source="Nicolas_upshift_promotors" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3031923) /Source="Nicolas_upshifts" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3032010..3032579) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome-associated sigma 54 modulation protein;ribosome dimerisation factor" /protein_id="NP_391411.1" /db_xref="EnsemblGenomes-Gn:BSU35310" /db_xref="EnsemblGenomes-Tr:CAB15548" /db_xref="GOA:P28368" /db_xref="InterPro:IPR003489" /db_xref="InterPro:IPR032528" /db_xref="InterPro:IPR034694" /db_xref="InterPro:IPR036567" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10740" /db_xref="UniProtKB/Swiss-Prot:P28368" /translation="MNYNIRGENIEVTPALKDHVERKIGKLERYFDHSVDADVNVNLK FYNDKESKVEVTIPMTDLALRSEVHNEDMYNAIDLATNKLERQIRKHKTKVNRKFREQ GSPKYLLANGLGSDTDIAVQDDIEEEESLDIVRQKRFNLKPMDSEEAILQMNMLGHNF FVFTNAETNLTNVVYRRNDGKYGLIEPTE*" /label="hpf CDS" gene complement(3032010..3032579) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /label="hpf gene" downshifts complement(3032018) /Source="Nicolas_upshifts" /id="D1830" /incds=0 /nref=78 /ntot=209 /MaxReadThrough="8.66806" /MaxDrop="4.7023" /score="29.9030506" /energy="-12.2" /TU="U2768,U2769,U2770,U2773" /idTUdmin="U2773" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 3032546..3032552 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3032565..3032584 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3032572 /Source="Nicolas_upshifts" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3032606..3032624) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3032614) /Source="Nicolas_upshifts" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3032616..>3032717) /Source="Nicolas_S_feature" /locus_tag="new_3631609_3631729_c" /HighExp="C30, M0t90, S4, Lbstat, S5, M40t90, Glucon, Gly, C90, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigD, SigD" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1350" promotor_-35 complement(3032636..3032644) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 3032717..3032718 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_008" CDS complement(3032721..3033203) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:24706744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24706744; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for flagellar based motility" /protein_id="NP_391422.1" /db_xref="EnsemblGenomes-Gn:BSU35420" /db_xref="EnsemblGenomes-Tr:CAB15559" /db_xref="GOA:P39808" /db_xref="InterPro:IPR007809" /db_xref="InterPro:IPR036679" /db_xref="SubtiList:BG10400" /db_xref="UniProtKB/Swiss-Prot:P39808" /translation="MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILT KEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVL GRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA *" /label="flgN CDS" gene complement(3032721..3033203) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /label="flgN gene" CDS complement(3033219..3033485) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma factor repressor of sigma(D)-dependent transcription" /protein_id="NP_391423.1" /db_xref="EnsemblGenomes-Gn:BSU35430" /db_xref="EnsemblGenomes-Tr:CAB15560" /db_xref="GOA:P39809" /db_xref="InterPro:IPR007412" /db_xref="InterPro:IPR031316" /db_xref="InterPro:IPR035890" /db_xref="SubtiList:BG10399" /db_xref="UniProtKB/Swiss-Prot:P39809" /translation="MKINQFGTQSVNPYQKNYDKQAVQKTVAQPQDKIEISSQAKEMQ HASDAVTGSRQEKIAQLKAQIENGSYKVDANHIAKNMINFYKKQ*" /label="flgM CDS" gene complement(3033219..3033485) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /label="flgM gene" S_feature complement(3033486..3033565) /Source="Nicolas_S_feature" /locus_tag="new_3640552_3640631_c" /HighExp="T0.30H, Cold, C90, T-5.40H, T-4.40H, GM 150, T-2.40H, GM 45, S2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1353" CDS complement(3033566..3033985) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696775; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of flagella formation" /protein_id="NP_391424.1" /db_xref="EnsemblGenomes-Gn:BSU35440" /db_xref="EnsemblGenomes-Tr:CAB15561" /db_xref="GOA:P39807" /db_xref="InterPro:IPR022258" /db_xref="SubtiList:BG10398" /db_xref="UniProtKB/Swiss-Prot:P39807" /translation="MGELANCPKCNALFLKTKLQTVCQACIKEEEKSFETVYKFLRKQ ENRQSTLSRITEETGVEEELILKFIRQKRIQITHLPNLAYPCERCGTSIREGKFCKAC QSDIKDQMDHLNHEDALKIEKENSKKDTYYAYNTKNS*" /label="yvyF CDS" gene complement(3033566..3033985) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /label="yvyF gene" promotor_-10 complement(3034024..3034042) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3034035) /Source="Nicolas_upshifts" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3034056..3034063) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3034059..3034781) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 28618091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the DNA transport apparatus" /protein_id="NP_391425.2" /db_xref="EnsemblGenomes-Gn:BSU35450" /db_xref="EnsemblGenomes-Tr:CAB15562" /db_xref="GOA:P39147" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005222" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10397" /db_xref="UniProtKB/Swiss-Prot:P39147" /translation="MSNEAGGGIHKLICLLCDSQFSQDVTWRALFLLKPDEKVCYSCR SKLKKITGHICPLCGRPQSVHAVCRDCEVWRTRIRDSLLLRQNRSVYTYNDMMKETLS RFKFRGDAEIINAFKSDFSSTFSKVYPDKHFVLVPIPLSKEREEERGFNQAHLLAECL DRPSHHPLIRLNNEKQSKKKKTERLLSECIFDTKNNSAEGMNIILIDDLYTTGATLHF AARCLLEKGKAASVSSFTLIRS*" /label="comFC CDS" gene complement(3034059..3034781) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /label="comFC gene" CDS complement(3034745..3035041) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 25423369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 25423369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of competence, pole located" /protein_id="NP_391426.1" /db_xref="EnsemblGenomes-Gn:BSU35460" /db_xref="EnsemblGenomes-Tr:CAB15563" /db_xref="GOA:P39146" /db_xref="InterPro:IPR019657" /db_xref="PDB:4WAI" /db_xref="SubtiList:BG10396" /db_xref="UniProtKB/Swiss-Prot:P39146" /translation="MLVNSKEIVMKELLDRYMDQLHMACTCQVCQNDVLALSLNKVSP SYVTDFKKIAYTKAELVDKQKNTAMLVILAESAAVVSESPSDLCQTKQEEAFIN*" /label="comFB CDS" gene complement(3034745..3035041) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /label="comFB gene" promotor_-10 complement(3035067..3035086) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3035080) /Source="Nicolas_upshifts" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3035097..3035104) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3035101..3036492) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045895, 11359569, 12123453, 16009133, 21397556, 28559293" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045895, 11359569, 12123453, 16009133, 21397556, 28559293; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase competence protein" /protein_id="NP_391427.1" /db_xref="EnsemblGenomes-Gn:BSU35470" /db_xref="EnsemblGenomes-Tr:CAB15564" /db_xref="GOA:P39145" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10395" /db_xref="UniProtKB/Swiss-Prot:P39145" /translation="MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGY ITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSW KEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGI ESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTH QLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKAL NGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFL FVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVT VPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIK EMNELAAKVECTD*" /label="comFA CDS" gene complement(3035101..3036492) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /label="comFA gene" promotor_-10 complement(3036506..3036525) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3036521) /Source="Nicolas_upshifts" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3036539..3036546) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3036598..3037443) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /EC_number="2.7.2.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit A" /protein_id="NP_391428.1" /db_xref="EnsemblGenomes-Gn:BSU35480" /db_xref="EnsemblGenomes-Tr:CAB15565" /db_xref="GOA:P32436" /db_xref="InterPro:IPR003797" /db_xref="PDB:3FYS" /db_xref="SubtiList:BG10394" /db_xref="UniProtKB/Swiss-Prot:P32436" /translation="MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELD WKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAA DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFM VDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLD EDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGI CWCFK*" /label="fakBA CDS" gene complement(3036598..3037443) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /label="fakBA gene" downshifts complement(3036609) /Source="Nicolas_upshifts" /id="D1835" /incds=0 /nref=207 /ntot=249 /MaxReadThrough="2.43976" /MaxDrop="5.65998" /score="25.7738948" /energy="-9.9" /TU="NA" /idTUdmin="U2779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3036860..3036867 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3036881..3036900 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3036891..3038623 /Source="Nicolas_S_feature" /locus_tag="new_3643957_3645689" /HighExp="C30, S2, C90, Pyr, T0.30H, GM 150, G/S, T-4.40H, T-3.40H, T1.30H" /AntisenseName="degU" /AntisenseCor="1.0564647169900101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1354" upshifts 3036891 /Source="Nicolas_upshifts" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3037470..3037489) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3037489) /Source="Nicolas_upshifts" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3037504..3037507) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3037541..3038230) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_391429.1" /db_xref="EnsemblGenomes-Gn:BSU35490" /db_xref="EnsemblGenomes-Tr:CAB15566" /db_xref="GOA:P13800" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10393" /db_xref="UniProtKB/Swiss-Prot:P13800" /translation="MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARI VEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARG YLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIR RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVV VAIKNGWVEMR*" /label="degU CDS" gene complement(3037541..3038230) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /label="degU gene" downshifts complement(3037555) /Source="Nicolas_upshifts" /id="D1836" /incds=0 /nref=178 /ntot=235 /MaxReadThrough="5.12878" /MaxDrop="6.38336" /score="20.9249268" /energy="-12.8" /TU="U2781" /idTUdmin="U2779" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature complement(3038231..3038312) /Source="Nicolas_S_feature" /locus_tag="new_3645297_3645378_c" /HighExp="M40t90, Lbtran, M0t90, LBGtran, G180, T3.0H, M40t45, C90, T3.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1355" CDS complement(3038313..3039470) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [DegU]" /protein_id="NP_391430.1" /db_xref="EnsemblGenomes-Gn:BSU35500" /db_xref="EnsemblGenomes-Tr:CAB15567" /db_xref="GOA:P13799" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008595" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR016381" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10392" /db_xref="UniProtKB/Swiss-Prot:P13799" /translation="MNKTKMDSKVLDSILMKMLKTVDGSKDEVFQIGEQSRQQYEQLV EELKQIKQQVYEVIELGDKLEVQTRHARNRLSEVSRNFHRFSEEEIRNAYEKAHKLQV ELTMIQQREKQLRERRDDLERRLLGLQEIIERSESLVSQITVVLNYLNQDLREVGLLL ADAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDRGAEDG FQEIKNLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLYTTEEYNGKVKIHFQ CIGETEDQRLAPQFEVALFRLAQEAVSNALKHSESEEITVKVEITKDFVILMIKDNGK GFDLKEAKEKKNKSFGLLGMKERVDLLEGTMTIDSKIGLGTFIMIKVPLSL*" /label="degS CDS" gene complement(3038313..3039470) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /label="degS gene" S_feature complement(3039471..3039598) /Source="Nicolas_S_feature" /locus_tag="new_3646537_3646664_c" /HighExp="T0.30H, Lbtran, M9-stat, T3.0H, T1.0H, HiOs, T1.30H, T2.30H, T3.30H, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1356" promotor_-35 3039518..3039521 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3039536..3039555 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3039547..3039633 /Source="Nicolas_S_feature" /locus_tag="new_3646613_3646699" /HighExp="UNK1, Cold, C30, Lbexp, MG 15, G135, G180, G150, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1357" upshifts 3039547 /Source="Nicolas_upshifts" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3039592..3039611) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3039598) /Source="Nicolas_upshifts" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3039615..3039623 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3039622..3039629) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3039635 /Source="Nicolas_upshifts" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3039637..3039645 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3039687..3040340 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11116084, 15103642, 21239490, 22404850; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative translation regulator" /protein_id="NP_391431.1" /db_xref="EnsemblGenomes-Gn:BSU35510" /db_xref="EnsemblGenomes-Tr:CAB15568" /db_xref="InterPro:IPR001498" /db_xref="InterPro:IPR015269" /db_xref="InterPro:IPR015796" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020569" /db_xref="InterPro:IPR023582" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR036956" /db_xref="SubtiList:BG11052" /db_xref="UniProtKB/Swiss-Prot:P32437" /translation="MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIK KQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYF GGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFL LKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE* " /label="yvyE CDS" gene 3039687..3040340 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /label="yvyE gene" S_feature complement(3040043..3040635) /Source="Nicolas_S_feature" /locus_tag="new_3647109_3647701_c" /HighExp="Etha, M9-stat, Gly, C30, B60, Salt, T0.30H, Sw, LoTm, S8" /AntisenseName="yvyE" /AntisenseCor="-0.139956338862644" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1358" CDS 3040340..3041515 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19099556, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain" /protein_id="NP_391432.1" /db_xref="EnsemblGenomes-Gn:BSU35520" /db_xref="EnsemblGenomes-Tr:CAB15569" /db_xref="GOA:P96499" /db_xref="InterPro:IPR004474" /db_xref="PDB:3NXH" /db_xref="SubtiList:BG12449" /db_xref="UniProtKB/Swiss-Prot:P96499" /translation="MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLY KTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVV TLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPID KYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYA RMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGL ALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDT STGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY* " /label="tagV CDS" gene 3040340..3041515 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /label="tagV gene" promotor_-10 complement(3040631..3040649) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3040640) /Source="Nicolas_upshifts" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3040663..3040669) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3041487 /Source="Nicolas_upshifts" /id="D1837" /incds=0 /nref=199 /ntot=276 /MaxReadThrough="2.38202" /MaxDrop="7.1642" /score="16.6000843" /energy="-18.6" /TU="NA" /idTUdmin="U2782" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(3041588..3042664) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /EC_number="2.7.8.33" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase" /protein_id="NP_391433.1" /db_xref="EnsemblGenomes-Gn:BSU35530" /db_xref="EnsemblGenomes-Tr:CAB15570" /db_xref="GOA:O34753" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG12684" /db_xref="UniProtKB/Swiss-Prot:O34753" /translation="MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRK VHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAK VKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDG LDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTG SLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDK SHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIA EVTGLVNEKFKPFTKFYKRLVKRN*" /label="tagO CDS" gene complement(3041588..3042664) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /label="tagO gene" downshifts complement(3041604) /Source="Nicolas_upshifts" /id="D1838" /incds=0 /nref=221 /ntot=280 /MaxReadThrough="1.7614" /MaxDrop="8.41647" /score="29.109706" /energy="-11.6" /TU="NA" /idTUdmin="U2785" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 3041650..3041659 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3041673..3041692 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3041681..3042914 /Source="Nicolas_S_feature" /locus_tag="new_3648747_3649980" /HighExp="S8, S6, S7, S5, BT, S4, B36, Pyr, S3, G/S" /AntisenseName="tagO" /AntisenseCor="-0.60515751332040901" /AntisenseRegPval="-27.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1359" upshifts 3041681 /Source="Nicolas_upshifts" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3042665..3042747) /Source="Nicolas_S_feature" /locus_tag="new_3649731_3649813_c" /HighExp="LPhT, Cold, LoTm, T0.30H, T3.0H, LBGstat, T1.30H, T1.0H, T2.30H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67123699999999997" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1360" promotor_-10 complement(3042735..3042754) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3042747) /Source="Nicolas_upshifts" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3042766..3042772) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3042809..3044002) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391434.1" /db_xref="EnsemblGenomes-Gn:BSU35540" /db_xref="EnsemblGenomes-Tr:CAB15571" /db_xref="GOA:O32267" /db_xref="SubtiList:BG12695" /db_xref="UniProtKB/Swiss-Prot:O32267" /translation="METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIW VCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPAS ANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAE LRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQG REGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIW TGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKM QKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTG IQKHA*" /label="tuaH CDS" gene complement(3042809..3044002) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /label="tuaH gene" downshifts complement(3042839) /Source="Nicolas_upshifts" /id="D1839" /incds=0 /nref=23 /ntot=141 /MaxReadThrough="7.20583" /MaxDrop="4.88676" /score="4.72365619" /energy="-10.8" /TU="U2786" /idTUdmin="U2785" /TUdmin="-1236" /isTUend="FALSE" /label="downshifts" CDS complement(3044031..3044789) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391435.1" /db_xref="EnsemblGenomes-Gn:BSU35550" /db_xref="EnsemblGenomes-Tr:CAB15572" /db_xref="GOA:O32268" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12694" /db_xref="UniProtKB/Swiss-Prot:O32268" /translation="MTNWKPLVSVITPSYNARDYIEDTVHSVLDQSHPHWEMIIVDDC STDGTRDILQQYEKIDERIHVVYLEENSGAAVARNKALERAQGRYVAFLDSDDKWKKD KLEKQLEFMMERSCAFSFTGYSLMAQDGTPLDKFIHAPESLTYDDALKNTIIGCLTVM IDREQTGQIQMPNIRTRQDLATWLSLLKKGFTAYGMNECLAEYRLVNNSISSNKWKAA KKTWFVYREIERLHFMKATWCFVQYAKNAVKKRL*" /label="tuaG CDS" gene complement(3044031..3044789) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /label="tuaG gene" CDS complement(3044813..3045493) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in teichuronic acid synthesis" /protein_id="NP_391436.1" /db_xref="EnsemblGenomes-Gn:BSU35560" /db_xref="EnsemblGenomes-Tr:CAB15573" /db_xref="GOA:O32269" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG12693" /db_xref="UniProtKB/Swiss-Prot:O32269" /translation="MNDILIRIARRIKKNIIWIIAVPIILGAAGYILPSQIADQKSYT AEDTLAVGSYDHPVYNSTEEIPLLLKSDSFLKEALPDEKDEDVAEIKEKLTINTESKS LLTLSYSDEDKDRTESVLNAISSTFLKNDQKLYAEREAVIRSSIDALEGESVSEDSKV DKERFLYELKNTQLNLKAASVTDSETVSETAGGGMSPKKKAVLGVMIGLTIAFMFVVI PEFFRESF*" /label="tuaF CDS" gene complement(3044813..3045493) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /label="tuaF gene" CDS complement(3045522..3046988) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 15849754, 16850406, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative polymerase of teichuronic acid repeating units" /protein_id="NP_391437.1" /db_xref="EnsemblGenomes-Gn:BSU35570" /db_xref="EnsemblGenomes-Tr:CAB15574" /db_xref="GOA:O32270" /db_xref="InterPro:IPR007016" /db_xref="SubtiList:BG12692" /db_xref="UniProtKB/Swiss-Prot:O32270" /translation="MSIKRSAVHTLALLAAAIFGVVLLLGAIHKDIGFMQMAAVLAVL AIGLFLLTLATAFTTKERLFMAVIYILIACTFLNNAFFAIHLGFFSLFLYRLLLIAAG CLHIFGMVRNRTHIERWHGLQVKGILLFFAFWFIYGLVSLLWAKSVTVGLKYLALLAM GIFFIYLIVMYVQKMERLMIVYAIWLVMTVFLMIIGFYNHITHHHLASSTLYSGPEYK QHYPTSVFFNQNDFATFLSISFFFYITMMKNIKNGYIKAIGLVLSLCALYLIFATGSR ASLLGIFAGIAVYIFIVLPPVLKRMAIWLSAAGIALFAVLFASKIYSKFWELFLAPQT LHSFHDRLPSNVARANLLKNAWHFFLDSYGFGVGAGNVSYYLEHYAVYDTDNVAEVHN WLVEILANFGLFIMLGYLSVYAYLIWVLYKFYERKLENQSKLITEGLITAMVSFLVSS ISPSSVSNLFFHWVFMALVIAAVNVLRRSRQMPEPMYR*" /label="tuaE CDS" gene complement(3045522..3046988) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /label="tuaE gene" S_feature complement(3046989..3047072) /Source="Nicolas_S_feature" /locus_tag="new_3654055_3654138_c" /HighExp="LPhT, S3, B60, S7, S4, S6, LBGstat, BI, S8, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1361" CDS complement(3047073..3048458) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10376820, 10913081, 12970183, 16000785, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376820, 10913081, 12970183, 16000785, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase (teichuronic acid)" /protein_id="NP_391438.1" /db_xref="EnsemblGenomes-Gn:BSU35580" /db_xref="EnsemblGenomes-Tr:CAB15575" /db_xref="GOA:O32271" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12691" /db_xref="UniProtKB/Swiss-Prot:O32271" /translation="MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGV IPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKA AAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISF INDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSA GYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALD IIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKE MELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLE ELAKDLGSVNL*" /label="tuaD CDS" gene complement(3047073..3048458) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /label="tuaD gene" CDS complement(3048520..3049689) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391439.1" /db_xref="EnsemblGenomes-Gn:BSU35590" /db_xref="EnsemblGenomes-Tr:CAB15576" /db_xref="GOA:O32272" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG12690" /db_xref="UniProtKB/Swiss-Prot:O32272" /translation="MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPF HSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTM KQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKR AVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLD QRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNH QVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPK SAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV*" /label="tuaC CDS" gene complement(3048520..3049689) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /label="tuaC gene" CDS complement(3049686..3051137) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10048024, 11994144, 15849754, 16850406, 22720735, 26284661; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative exporter involved in biosynthesis of teichuronic acid" /protein_id="NP_391440.1" /db_xref="EnsemblGenomes-Gn:BSU35600" /db_xref="EnsemblGenomes-Tr:CAB15577" /db_xref="GOA:O32273" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG12689" /db_xref="UniProtKB/Swiss-Prot:O32273" /translation="MPSITKQIMSGAKWTSISTMCITIIQIVQFALLGNMMTLTEFGL VGMITTVTVFAQIVLDMGFGAALIQRDDATERQLSTLYWLNIMTGVLLFVLLYVSSPV IAGFYQREELVFLVRILAIMFLIAPIGQQYQYMLQKQLHFNTLSKIEIFSNVLSFGYL AIAVFMMDAILAYVISQVLLQSSKGILYWAVYRKKWHPAFVFDLRGMKDFFSFGAFQL SSRLVNRLGANIDMILIGRFIGAEALGIYNLAYQIVTIPVLKINPIVTRVAFPIFAKN KYENSVIREGFLNMTKMLALVSFPLLIGLVSVSDAFITAVFGEKWLAAVPILNVLAIV GILRVLMNPNGSVLLAKGRADLAFYWDSGVLLLYGLSLFAAVQTGSLLTVAWVYAIIS VVNFLIGRWLLAYVIKLNLSAYFQSIMKPFLITAAMGIIAFGVSLSTEHFSMQAEMRL AISVAAGALCYLFLLVKAYPQTKSKLLRKGRLS*" /label="tuaB CDS" gene complement(3049686..3051137) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /label="tuaB gene" CDS complement(3051193..3051342) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; C-terminal part of TuaA" /db_xref="SubtiList:BG12688" /translation="WAQVNGGYDMTPKEKLIFDLYYIRNLTFTLELKIMLKTCKVVWT GDGAR*" /label="tuaAc CDS" gene complement(3051193..3051342) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /pseudo /label="tuaAc gene" CDS complement(3051287..3051826) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /EC_number="2.7.8.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 10048024, 11994144, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; N-terminal part of TuaA" /translation="MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALI GLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWA QKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQ RLGSGERRLRYDAEGKADI*" /label="tuaAn CDS" gene complement(3051287..3051826) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /pseudo /label="tuaAn gene" misc_feature complement(3051882..3051899) /Source="Nicolas_upshift_promotors" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3051886) /Source="Nicolas_upshifts" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3052053..3053543) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /EC_number="3.5.1.28" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1357079, 9537764, 14594841, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9537764, 14594841, 17298895, 19542270, 22469514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (major autolysin)" /protein_id="NP_391442.1" /db_xref="EnsemblGenomes-Gn:BSU35620" /db_xref="EnsemblGenomes-Tr:CAB15579" /db_xref="GOA:Q02114" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007253" /db_xref="SubtiList:BG10407" /db_xref="UniProtKB/Swiss-Prot:Q02114" /translation="MRSYIKVLTMCFLGLILFVPTALADNSVKRVGGSNRYGTAVQIS KQMYSTASTAVIVGGSSYADAISAAPLAYQKNAPLLYTNSDKLSYETKTRLKEMQTKN VIIVGGTPAVSSNTANQIKSLGISIKRIAGSNRYDTAARVAKAMGATSKAVILNGFLY ADAPAVIPYAAKNGYPILFTNKTSINSATTSVIKDKGISSTVVVGGTGSISNTVYNKL PSPTRISGSNRYELAANIVQKLNLSTSTVYVSNGFSYPDSIAGATLAAKKKQSLILTN GENLSTGARKIIGSKNMSNFMIIGNTPAVSTKVANQLKNPVVGETIFIDPGHGDQDSG AIGNGLLEKEVNLDIAKRVNTKLNASGALPVLSRSNDTFYSLQERVNKAASAQADLFL SIHANANDSSSPNGSETYYDTTYQAANSKRLAEQIQPKLAANLGTRDRGVKTAAFYVI KYSKMPSVLVETAFITNASDASKLKQAVYKDKAAQAIHDGTVSYYR*" /label="lytC CDS" gene complement(3052053..3053543) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /label="lytC gene" downshifts complement(3052075) /Source="Nicolas_upshifts" /id="D1840" /incds=0 /nref=145 /ntot=213 /MaxReadThrough="3.26689" /MaxDrop="6.50948" /score="13.9455176" /energy="-13.3" /TU="NA" /idTUdmin="U2788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3053582..3055699) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 16306698, 17269748" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 16306698, 17269748; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modifier of major autolysin amidase LytC" /protein_id="NP_391443.1" /db_xref="EnsemblGenomes-Gn:BSU35630" /db_xref="EnsemblGenomes-Tr:CAB15580" /db_xref="GOA:Q02113" /db_xref="InterPro:IPR007253" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="SubtiList:BG10406" /db_xref="UniProtKB/Swiss-Prot:Q02113" /translation="MKSCKQLIVCSLAAILLLIPSVSFAADSNISVKLLNYIGNKSSI SLSPTGFYKVTGDNVAVTDRFAGASRYETATLASNSQWKNPNTVILVNRDIFIDALPV IPLAKKLNAPVLFTQPDTLTKTTERQIAKFNPDNILIIGGARSISKDVENKLKSYGAV KRISGKNRYVLSENIAKQMGSYDKAIVVTGRVFQDALAIAPYAAAHGYPILLTEKDKL PDYDLPKQVIIIGSSFSVSDSVENQIKKTSTVQRIPGSTRYELTANIIKQLKLKADKV VMTNGTKYADVLIGASLASKKNSQILFVKQDSVPAAAKSITKDKATYAYDFIGSTSSI SAEVENSLADEFYLADGGTYNLKINSGKLNLENIKTYGNSLRIKPENYSTSNRISLDG KQYLGTVNFSIESTKYIRPVNENIPFEDYLKGVIPNEMPASWSLEALKAQTVAARTYS ITKTGTTVPDTTAFQVYGGYSWNSNTNKAVEQTKGKVLKYNGSLITAAYSSSNGGYTE ASNEVWSSSVPYLIAKKDTKDPQIGWTLTLSKQQLDTKSLDLTKPSSWWSSATETDSA RLSGVKNWILKNKETSADSVKIASIDDLSFSGTTQGQRAKTASMKVKYFVKSSTGSYN LSKITTISVPTSELRTMIGATVFKSTYVTVKKDTSKYTISGKGYGHGIGMSQYGAKAR AEAGDSYSSILKFYYPGTTLTSY*" /label="lytB CDS" gene complement(3053582..3055699) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /label="lytB gene" CDS complement(3055723..3056031) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1357079, 10974124, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 10974124, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="membrane bound lipoprotein" /protein_id="NP_391444.1" /db_xref="EnsemblGenomes-Gn:BSU35640" /db_xref="EnsemblGenomes-Tr:CAB15581" /db_xref="GOA:Q02112" /db_xref="SubtiList:BG10405" /db_xref="UniProtKB/Swiss-Prot:Q02112" /translation="MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVG LADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN *" /label="lytA CDS" gene complement(3055723..3056031) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /label="lytA gene" downshifts 3055937 /Source="Nicolas_upshifts" /id="D1841" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.03108" /MaxDrop="2.46089" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2787" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 3056027..3056031 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3056040..3056054 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3056041..3056059) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3056047 /Source="Nicolas_upshifts" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3056073..3056080) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3056076) /Source="Nicolas_upshifts" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3056097..3056105 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3056119..3056132 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3056137 /Source="Nicolas_upshifts" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="upshifts" CDS 3056215..3057135 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 9636707, 12034833, 19099556, 28197687, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9636707, 12034833, 19099556, 28197687, 29107701; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of major autolysin expression" /protein_id="NP_391445.1" /db_xref="EnsemblGenomes-Gn:BSU35650" /db_xref="EnsemblGenomes-Tr:CAB15582" /db_xref="GOA:Q02115" /db_xref="InterPro:IPR004474" /db_xref="InterPro:IPR023734" /db_xref="SubtiList:BG10404" /db_xref="UniProtKB/Swiss-Prot:Q02115" /translation="MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVAS IHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMV SIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVV DTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVI QGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGT GTKINGIYYYQADESALSDITKELKESLEK*" /label="tagU CDS" gene 3056215..3057135 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /label="tagU gene" downshifts 3057125 /Source="Nicolas_upshifts" /id="D1842" /incds=0 /nref=224 /ntot=261 /MaxReadThrough="0.434639999999999" /MaxDrop="6.11301" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2789" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3057175..3058317) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /EC_number="5.1.3.14" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12107153, 16952950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12107153, 16952950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmannosamine 2-epimerase" /protein_id="NP_391446.1" /db_xref="EnsemblGenomes-Gn:BSU35660" /db_xref="EnsemblGenomes-Tr:CAB15583" /db_xref="GOA:P39131" /db_xref="InterPro:IPR003331" /db_xref="InterPro:IPR029767" /db_xref="PDB:1O6C" /db_xref="PDB:4FKZ" /db_xref="SubtiList:BG10403" /db_xref="UniProtKB/Swiss-Prot:P39131" /translation="MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQ MLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTT FAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLL KENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMEN MFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAK SHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLL TDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK*" /label="mnaA CDS" gene complement(3057175..3058317) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /label="mnaA gene" downshifts complement(3057199) /Source="Nicolas_upshifts" /id="D1843" /incds=0 /nref=126 /ntot=236 /MaxReadThrough="0.41249" /MaxDrop="5.56107" /score="7.64930656" /energy="-11" /TU="NA" /idTUdmin="U2790" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3058356..3058375) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3058370) /Source="Nicolas_upshifts" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3058390..3058393) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3058446..3058450 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3058466..3058485 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3058467..3058562 /Source="Nicolas_S_feature" /locus_tag="new_3665533_3665628" /HighExp="C90, dia5, Salt, Lbexp, T1.0H, MG 5, GM 90, MG 45, LoTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1362" upshifts 3058468 /Source="Nicolas_upshifts" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="upshifts" CDS 3058563..3059441 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2846750, 8126437, 8320212, 9658024, 17662947, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846750, 8126437, 8320212, 9658024, 17662947, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_391447.1" /db_xref="EnsemblGenomes-Gn:BSU35670" /db_xref="EnsemblGenomes-Tr:CAB15584" /db_xref="GOA:Q05852" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10402" /db_xref="UniProtKB/Swiss-Prot:Q05852" /translation="MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEE AVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYI RQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQ QVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLE EQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELR DQLVPFMEGLLNKEEI*" /label="gtaB CDS" gene 3058563..3059441 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /label="gtaB gene" S_feature 3059442..3060533 /Source="Nicolas_S_feature" /locus_tag="new_3666508_3667599" /HighExp="Etha, Gly, C30, M9-stat, B60, T1.30H, B36, T1.0H, M40t90, T0.30H" /AntisenseName="yvzH" /AntisenseCor="-0.24043295548020899" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1363" S_feature complement(3059511..3059866) /Source="Nicolas_S_feature" /locus_tag="new_3666577_3666932_c" /HighExp="C30, LPh, HPh, Gly, G135, HiOs, aero, GM 25, MG 25, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.74940200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig="0.996" /label="S1364" CDS 3059775..3059993 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514004.1" /translation="MATILIPLTTLLDLSRIVGLIENHGIKPASIQTIKGTSPIPVMT SLLLRIPNTNQYAIIRIRGFKTCHNTPK*" /label="hypothetical protein CDS" gene 3059775..3059993 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /label="gene" CDS complement(3059867..3059950) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative teichoic acid translocation permease protein tagG (fragment)" /db_xref="PSEUDO:CAX52700.1" /translation="MMAYWFVFGMRNSKLVITGIGEVPFIV*" /label="yvzH CDS" gene complement(3059867..3059950) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /pseudo /label="yvzH gene" S_feature complement(3059951..3060142) /Source="Nicolas_S_feature" /locus_tag="new_3667017_3667208_c" /HighExp="HPh, LPh, C30, Gly, S0, HiOs, aero, G135, Mal, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1365" CDS complement(3060143..3062845) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16735734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16735734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase" /protein_id="NP_391448.1" /db_xref="EnsemblGenomes-Gn:BSU35680" /db_xref="EnsemblGenomes-Tr:CAB15585" /db_xref="GOA:P46918" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR007554" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11192" /db_xref="UniProtKB/Swiss-Prot:P46918" /translation="MNEKSFNYDFSVIMPIYNVELYLTEAIESIINQTIGFENIQLIL VNDDSPDKSEIICKEYAQKYPNNIVYAKKQNGGVSSARNYGLKYAEGRYIQFLDPDDL VSEGTFENVLNFFDEHKNEIDIVAIPIFFAEGRTGEHNLNNKFSSTRILDVEKEPHHI LTHCCSTFIKKDALKNIRFDENCKIGEDAKLVNLIISQKKKYGLVKEAKYHYRVREDG SSAMQTAKANKNWFNHSLITFSKNLIDIIKNHEQKIPLFLQYMVMHDLKWKLLIKDIS ETPLDENEYSEFLTLIREVLSYIDDDVIIETKSVSHFYLYHALKIKHGENYSRYVYER ETEQDYYLYREGKIVSKLSDQTLTIEILEENEDSIHIEGFWSSLFNSKGFKFYAKIGE TKIKAKNIKRQHNDYISLGEVIKKYPGFSIDIPKGHLADNHHIEFFITKGKKRKLTKL RFFKYSGLSNDLYNTYVAKKDYIFYYNYKKLMFKKNNFKNRFIKEFRFLKSLHKSGEK SKKRKSAIKKALMARMVHHVFTIFNRKPVWLFIDRQDKADDNAEHLFKYAINKNDGVK KYFIIKKDSKDYDRIKKYGKVIPYRSFRHKILTLSSSKVISTHADIWVVNPFFNMEIY FRDLFNFEFIFLQHGITMADHSEWLNKYNKNIKLLVTSAKPEYRSIVKGNYNYKKENI LLGGFPRYDNLKKSEGEKQLLIMPTWRKDIVLPKDQAKGVRPYNPKFKDSEYFSRYNA LINDERLIEFAKKNNYKITFFPHPDIQQQIVDFEKHDYVEFADYNSSYQMLFNSSNIM ITDFSSVAFDFAYEKKPVIYYQYEKSYHFKLDYYDYKKMGFGDVLENHNSLVDKVIYY MKNNSRMEDKYRKRVDNFFAYTDKNNRNRIYNAILELDNNKVAK*" /label="ggaB CDS" gene complement(3060143..3062845) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /label="ggaB gene" S_feature complement(3062846..3062968) /Source="Nicolas_S_feature" /locus_tag="new_3669912_3670034_c" /HighExp="BMM, HiOs, MG 15, C30, SMM, GM 90, HPh, MG 150, MG 25, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1366" promotor_-35 3062867..3062873 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3062888..3062906 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3062893..3065725 /Source="Nicolas_S_feature" /locus_tag="new_3669959_3672791" /HighExp="Sw, LoTm, M9-stat, Salt, B60, T0.30H, Gly, T1.0H, B36, BI" /AntisenseName="ggaA" /AntisenseCor="-0.503651102561819" /AntisenseRegPval="-18" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1367" upshifts 3062893 /Source="Nicolas_upshifts" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3062969..3064309) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16735734, 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase (missing signal peptide)" /db_xref="EnsemblGenomes-Gn:BSU35690" /db_xref="EnsemblGenomes-Tr:CAB15586" /db_xref="GOA:P46917" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PSEUDO:CAB15586.1" /db_xref="SubtiList:BG11367" /db_xref="UniProtKB/Swiss-Prot:P46917" /translation="MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVD SSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNA LQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIG GTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLV DRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKS VLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERV LHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEV WGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR*" /label="ggaA CDS" gene complement(3062969..3064309) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /pseudo /label="ggaA gene" CDS complement(3064350..3064556) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /EC_number="2.7.8.12" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (fragment)" /db_xref="PSEUDO:CAX52701.1" /translation="MYDLPAYRDCIRGFYFNFQQKTPGNLLQTSEELIDTVKELLHNP YIDHNYEDFYNKFCNLEEARLLKE*" /label="yvzI CDS" gene complement(3064350..3064556) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /pseudo /label="yvzI gene" S_feature complement(3064557..3065430) /Source="Nicolas_S_feature" /locus_tag="new_3671623_3672496_c" /HighExp="HiOs, Heat, BMM, MG 15, GM 90, MG 25, MG 150, C30, GM 25, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99943499999999996" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1368" promotor_-10 complement(3065424..3065443) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3065430) /Source="Nicolas_upshifts" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3065432..3065671) /Source="Nicolas_S_feature" /locus_tag="new_3672498_3672737_c" /HighExp="Cold, LBGstat, C30, GM 25, GM 15, GM 45, GM 60, GM 10, GM-0.2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1369" promotor_-35 complement(3065456..3065462) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3065653..3065671) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-10" upshifts complement(3065671) /Source="Nicolas_upshifts" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="upshifts" promotor_-35 complement(3065685..3065692) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-35" promotor_-35 3065694..3065701 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3065713..3065732 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3065727..3065857 /Source="Nicolas_S_feature" /locus_tag="new_3672793_3672923" /HighExp="Sw, T0.30H, LoTm, B60, T1.0H, Lbtran, C30, LBGtran, dia5, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1370" upshifts 3065727 /Source="Nicolas_upshifts" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3065799..3065899 /Source="Nicolas_upshift_promotors" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3065859 /Source="Nicolas_upshifts" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS 3065863..3066459 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /EC_number="2.7.7.9" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (fragment)" /db_xref="PSEUDO:CAX52702.1" /translation="MISFFHYILQKEPKGLGHAVWFAPNFIGDEPFAFLLGDDIVQAD TPGLRQLTDEYERTLSSIIGVQQVPEDETHCYGIIAPLTSEGRRYQVKNFIEKPPKDT APSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYD VGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI*" /label="yvzE CDS" gene 3065863..3066459 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /pseudo /label="yvzE gene" downshifts 3066057 /Source="Nicolas_upshifts" /id="D1844" /incds=1 /nref=94 /ntot=183 /MaxReadThrough="4.62614" /MaxDrop="5.15039" /score="34.2325445" /energy="-14.3" /TU="U2792,U2795" /idTUdmin="U2796" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3066498..3068081) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /EC_number="3.6.3.40" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 17012386, 18156271; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding teichoic acid precursor transporter component" /protein_id="NP_391451.1" /db_xref="EnsemblGenomes-Gn:BSU35700" /db_xref="EnsemblGenomes-Tr:CAB15587" /db_xref="GOA:P42954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015860" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030284" /db_xref="SubtiList:BG11191" /db_xref="UniProtKB/Swiss-Prot:P42954" /translation="MKLKVSFRNVSKQYHLYKKQSDKIKGLFFPAKDNGFFAVRNVSF DVYEGETIGFVGINGSGKSTMSNLLAKIIPPTSGEIEMNGQPSLIAIAAGLNNQLTGR DNVRLKCLMMGLTNKEIDDMYDSIVEFAEIGDFINQPVKNYSSGMKSRLGFAISVHID PDILIIDEALSVGDQTFYQKCVDRINEFKKQGKTIFFVSHSIGQIEKMCDRVAWMHYG ELRMFDETKTVVKEYKAFIDWFNKLSKKEKETYKKEQTEERKKEDPEAFARFRKKKKK PKSLANAIQIAILSILTVFMAGTMFFNAPLRTIASFGAIPQNEVKNHHGDAKGKSEER LTAINKQGFIANEKAAAYKDQGLKQKADVTLPFGTKVTVAAKGKQAAKIKFDGHSYYV KQSAVATNMKHAELHATAFTSYVSQNAASSYEYFLKFLGDSSTSIQSKLNGYTEGNKA DGRKTLNFDYEKISYVLENDKATELIFHNISPINPASLSLSDSDVLYDSSKKRFLVNT DDQVFAVDNEEHTLTLMLK*" /label="tagH CDS" gene complement(3066498..3068081) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /label="tagH gene" downshifts 3066541 /Source="Nicolas_upshifts" /id="D1845" /incds=0 /nref=2 /ntot=19 /MaxReadThrough="1.20059" /MaxDrop="5.25978" /score="34.2325445" /energy="-14.3" /TU="NA" /idTUdmin="U2792" /TUdmin=440 /isTUend="FALSE" /label="downshifts" CDS complement(3068101..3068928) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 15849754, 16850406, 17012386, 18156271, 27213893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="teichoic acid precursors permease" /protein_id="NP_391452.1" /db_xref="EnsemblGenomes-Gn:BSU35710" /db_xref="EnsemblGenomes-Tr:CAB15588" /db_xref="GOA:P42953" /db_xref="InterPro:IPR000412" /db_xref="InterPro:IPR013525" /db_xref="SubtiList:BG11205" /db_xref="UniProtKB/Swiss-Prot:P42953" /translation="MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNP LIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKR INMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICM IAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLK LNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL* " /label="tagG CDS" gene complement(3068101..3068928) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /label="tagG gene" S_feature complement(3068929..3068993) /Source="Nicolas_S_feature" /locus_tag="new_3675995_3676059_c" /HighExp="H2O2, LBGstat, dia15, Oxctl, LBGexp, G150, Paraq, G180, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1371" promotor_-10 complement(3068989..3069008) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3068993) /Source="Nicolas_upshifts" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3068995..3069092) /Source="Nicolas_S_feature" /locus_tag="new_3676061_3676158_c" /HighExp="G180, G135, Cold, G150, LPh, S0, Oxctl, Paraq, HPh, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1372" promotor_-35 complement(3069024..3069027) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3069093..3071333) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /EC_number="2.7.8.12" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)" /protein_id="NP_391453.1" /db_xref="EnsemblGenomes-Gn:BSU35720" /db_xref="EnsemblGenomes-Tr:CAB15589" /db_xref="GOA:P13485" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10725" /db_xref="UniProtKB/Swiss-Prot:P13485" /translation="MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLG SLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPV EMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGN FSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEE KFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDD EGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLK TRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGK QYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEY WVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASN WDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDK KVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPF EGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGF YFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVN TVFKAE*" /label="tagF CDS" gene complement(3069093..3071333) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /label="tagF gene" CDS complement(3071333..3073354) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /EC_number="2.4.1.52" /function="16.8: Protect" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase" /protein_id="NP_391454.1" /db_xref="EnsemblGenomes-Gn:BSU35730" /db_xref="EnsemblGenomes-Tr:CAB15590" /db_xref="GOA:P13484" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015397" /db_xref="SubtiList:BG10724" /db_xref="UniProtKB/Swiss-Prot:P13484" /translation="MSLHAVSESNIKQIPDMDYYFISGGLPSNYGGLTKSLLLRSKLF GEECNQNTFFLTFRFDLELSSKIDELYSNGKIDKKFTSVINLFDDFLSVRTNGKRSYE ERIGLDQIKKQVGMGKFAKTLLRLFGKKNNEMSVVYYGDGETIRYVDYWNDKNQLIKR EEYTKNGNLVLVTHYDVQLNKMYLQEYINDQNQVYLDKLYVWNNEEKDVQLSHIIWYS LEGEIKVKDESELRQYWIEYLQKQNDKPKLFLVDSRPQDKHVFKVKKSPSSYYGAIIH NKHYGSNKYQIKGRYKEVFSQMYNLDAVFFITEEQLEDFKLISGEQETFFFTPHTIDK PLDPAVLNVPSEKYKAVIISRLASMKNLIHAVKAFSLVVKEIPEAKLDIFGSGEDFEK IKKEIEDTKLQNNVFLKGYTDNPDSEFQKAWLTISTSHFEGFGLSNMEALSNGCPVVT YDYDYGARSLVTDGANGYVIEQYNIEKLGQAIISLMKDESTHQKFSEQAFKMAEKYSR PNYIENWAFALNQMIEVRIEREKFSKKVGKKDPSISSYTEDFDKTKIEIDIENFDHND IKKIRLVGLDRKNKAEIISTNLQNDQLFVIDLEKDVNIEKIAANKTQVIDFYIVFNAN GHIKTMRRLSSEETKLSGNSIDTNNGYRVEPYTTVKGNFSWRVTEIKES*" /label="tagE CDS" gene complement(3071333..3073354) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /label="tagE gene" promotor_-35 3072096..3072105 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3072118..3072133 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3072129 /Source="Nicolas_upshifts" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3073355..3073514) /Source="Nicolas_S_feature" /locus_tag="new_3680421_3680580_c" /HighExp="G180, G135, Cold, G150, Oxctl, LBGexp, Paraq, Lbexp, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1373" CDS complement(3073515..3073904) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /EC_number="2.7.7.39" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol-3-phosphate cytidylyltransferase" /protein_id="NP_391455.1" /db_xref="EnsemblGenomes-Gn:BSU35740" /db_xref="EnsemblGenomes-Tr:CAB15591" /db_xref="GOA:P27623" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR006409" /db_xref="InterPro:IPR014729" /db_xref="PDB:1COZ" /db_xref="PDB:1N1D" /db_xref="SubtiList:BG10449" /db_xref="UniProtKB/Swiss-Prot:P27623" /translation="MKKVITYGTFDLLHWGHIKLLERAKQLGDYLVVAISTDEFNLQK QKKAYHSYEHRKLILETIRYVDEVIPEKNWEQKKQDIIDHNIDVFVMGDDWEGKFDFL KDQCEVVYLPRTEGISTTKIKEEIAGL*" /label="tagD CDS" gene complement(3073515..3073904) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /label="tagD gene" S_feature complement(3073905..3074039) /Source="Nicolas_S_feature" /locus_tag="new_3680971_3681105_c" /HighExp="BC, Cold, T3.0H, HiOs, MG-0.2, T1.30H, T3.30H, LPhT, MG 15, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1374" promotor_-10 complement(3074023..3074042) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3074039) /Source="Nicolas_upshifts" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3074053..3074060) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3074194..3074200 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3074211..3074303 /Source="Nicolas_S_feature" /locus_tag="new_3681277_3681369" /HighExp="B60, LoTm, Cold, T3.30H, T3.0H, Salt, T5.0H, T4.0H, Lbexp, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1375" upshifts 3074211 /Source="Nicolas_upshifts" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3074212..3074231 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3074304..3075074 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /EC_number="2.4.1.187" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase" /protein_id="NP_391456.1" /db_xref="EnsemblGenomes-Gn:BSU35750" /db_xref="EnsemblGenomes-Tr:CAB15592" /db_xref="GOA:P27620" /db_xref="InterPro:IPR004629" /db_xref="InterPro:IPR034714" /db_xref="SubtiList:BG10450" /db_xref="UniProtKB/Swiss-Prot:P27620" /translation="MQTETIHNIPYVNSNLTSFIDYLEKHYIDQKIGAVISTVNPEIA FAAIKDRDYFDVLSSSNFILPDGIGVVMMSRLTNNRLQSRIAGYDVFKELLGVANKKK KRIFLYGAKKDVIKGVVSKISSEYPNIKIAGYSDGYVQDRTLVAKQIARANPDMVFVA LGYPHQEKFIHNYRHLFPKAVSIGLGGSFDVFSGNVKRAPSWMIRLNLEWFYRLILNP WRWKRMLSIPKYALTVLKEEKNKKTFYPKPEKDHTKQI*" /label="tagA CDS" gene 3074304..3075074 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /label="tagA gene" S_feature complement(3074431..3074779) /Source="Nicolas_S_feature" /locus_tag="new_3681497_3681845_c" /HighExp="S8, S6, S7, S5, S4, G135, S3, C30, G180, ferm" /AntisenseName="tagA" /AntisenseCor="-0.35014495927301897" /AntisenseRegPval="-8.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1376" promotor_-10 complement(3074783..3074794) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3074787) /Source="Nicolas_upshifts" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3074809..3074815) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3075099 /Source="Nicolas_upshifts" /id="D1846" /incds=0 /nref=2 /ntot=103 /MaxReadThrough="6.64821" /MaxDrop="3.225" /score="-6.01444425" /energy="-10.9" /TU="U2800" /idTUdmin="U2800" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" CDS 3075107..3076252 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /EC_number="2.7.8.44" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase" /protein_id="NP_391457.1" /db_xref="EnsemblGenomes-Gn:BSU35760" /db_xref="EnsemblGenomes-Tr:CAB15593" /db_xref="GOA:P27621" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10451" /db_xref="UniProtKB/Swiss-Prot:P27621" /translation="MKIRSLLANCYLYFLSAIAFFLQWVKPESKVTLLISFEANAKAI LEEYEQGQYSYKLNILYTQQASAIAESFPNVDAYLLQEKNPIHLIKAVYLMFNSKVII TDNYFLLTSVLNKRKQTKCIQVWHANGSLKKFGLEDITNMQRTKTDIKRFQKVYSSYD YLTVGSEEMANIFKKSFGIKDNQLLKIGVPLTDPYYRENKKKISDTLNIQRKKIILYA PTFRDYNMQSIQLPFTEEQLIHQLKEEYVLFVKLHPAIQNNIDIKYSSDYIKDVSNYA LFDLLMAADILITDYSSVPFEFSILNKPILFYTYDLKLYQQKRGLVDNYLSIIPGRAC YDSESLINEIQTPFNYSKIKVFSDRWNKYSDGNSSQNLLNFIENLIS*" /label="tagB CDS" gene 3075107..3076252 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /label="tagB gene" downshifts 3076240 /Source="Nicolas_upshifts" /id="D1847" /incds=0 /nref=101 /ntot=235 /MaxReadThrough="3.54908" /MaxDrop="5.95551" /score="-3.22062454" /energy="-10" /TU="U2800" /idTUdmin="U2800" /TUdmin="-1169" /isTUend="FALSE" /label="downshifts" promotor_-35 3076294..3076301 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3076316..3076335 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3076326 /Source="Nicolas_upshifts" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="upshifts" CDS 3076372..3077700 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7952180, 16269821; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)" /protein_id="NP_391458.1" /db_xref="EnsemblGenomes-Gn:BSU35770" /db_xref="EnsemblGenomes-Tr:CAB15594" /db_xref="GOA:P27622" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG10453" /db_xref="UniProtKB/Swiss-Prot:P27622" /translation="MRKKELFDFTNITPKLFTELRVADKTVLQSFNFDEKNHQIYTTQ VASGLGKDNTQSYRITRLSLEGLQLDSMLLKHGGHGTNIGIENRNGTIYIWSLYDKPN ETDKSELVCFPYKAGATLDENSKELQRFSNMPFDHRVTPALDMKNRQLAIRQYDTKNN NNKQWVTIFNLDDAIANKNNPLYTINIPDELHYLQGFFLDDGYLYWYTGDTNSKSYPN LITVFDSDNKIVLQKEITVGKDLSTRYENNFREPEGICMYTNPETGAKSLMVGITSGK EGNRISRIYAYHSYENFMNHVPMLRSPLLKTVGHQDTPPERFQPFIQTFILEYNAQNK KWMVPTSGYLPSYTSNLVRNITINADGNLQVTLNERYISLLHQSIEGDFRLKQKDIRM GSWYFAGGEKSNVLEIGFMKGSTKIRPDDAAISNASRMSIFMIVADKIEV*" /label="tagC CDS" gene 3076372..3077700 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /label="tagC gene" downshifts 3077695 /Source="Nicolas_upshifts" /id="D1848" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.77356" /MaxDrop="4.002" /score="-7.52215775" /energy="-19.3" /TU="NA" /idTUdmin="U2802" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3077756) /Source="Nicolas_upshifts" /id="D1849" /incds=0 /nref=141 /ntot=248 /MaxReadThrough="0.94732" /MaxDrop="5.40128" /score="-0.11635468" /energy="-19.3" /TU="NA" /idTUdmin="U2803" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" SCAR 3077780..3077781 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_002" downshifts 3077804 /Source="Nicolas_upshifts" /id="D1854" /incds=0 /nref=163 /ntot=235 /MaxReadThrough="3.35965" /MaxDrop="5.65658" /score="24.125299" /energy="-9.8" /TU="NA" /idTUdmin="U2809" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3077857..3079098) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /EC_number="3.4.19.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12073126, 12644511, 16689787, 16952838, 26158264, 28664519" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073126, 12644511, 16689787, 16952838, 26158264, 28664519; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-DD-glutamyl hydrolase (PGA depolymerase)" /protein_id="NP_391467.1" /db_xref="EnsemblGenomes-Gn:BSU35860" /db_xref="EnsemblGenomes-Tr:CAB15603" /db_xref="GOA:P96740" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG12535" /db_xref="UniProtKB/Swiss-Prot:P96740" /translation="MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAK NLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGD ILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAA DPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQW AVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYW KSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKA AGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVT ITNMNTSTYWKDKYAGSIRVQ*" /label="pgdS CDS" gene complement(3077857..3079098) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /label="pgdS gene" downshifts complement(3077876) /Source="Nicolas_upshifts" /id="D1855" /incds=0 /nref=228 /ntot=317 /MaxReadThrough="2.27329" /MaxDrop="7.15996" /score="10.2499259" /energy="-9.8" /TU="NA" /idTUdmin="U2812" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3079120..3079138) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3079142) /Source="Nicolas_upshifts" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3079151..3079158) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3079239..3079406) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16267300, 16689787, 20812257, 21357437, 23583563, 25843804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267300, 16689787, 20812257, 21357437, 23583563, 25843804; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor required extrachromosomal elements maintenance" /protein_id="NP_391468.1" /db_xref="EnsemblGenomes-Gn:BSU35870" /db_xref="EnsemblGenomes-Tr:CAB15604" /db_xref="SubtiList:BG12534" /db_xref="UniProtKB/Swiss-Prot:P96739" /translation="MKFVKAIWPFVAVAIVFMFMSAFKFNDQLTDQEKQKIDMEMNKI QQQEEPVNANK*" /label="edmS CDS" gene complement(3079239..3079406) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /label="edmS gene" downshifts complement(3079266) /Source="Nicolas_upshifts" /id="D1856" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="0.6752" /MaxDrop="2.78178" /score="24.9141523" /energy="-14.7" /TU="NA" /idTUdmin="U2812" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" CDS complement(3079421..3080563) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /EC_number="6.3.2.-" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 12644511, 16689787, 19745567, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 12644511, 16689787, 19745567, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (acid resistance)" /protein_id="NP_391469.1" /db_xref="EnsemblGenomes-Gn:BSU35880" /db_xref="EnsemblGenomes-Tr:CAB15605" /db_xref="InterPro:IPR019079" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12533" /db_xref="UniProtKB/Swiss-Prot:P96738" /translation="MKKELSFHEKLLKLTKQQKKKTNKHVFIAIPIVFVLMFAFMWAG KAETPKVKTYSDDVLSASFVGDIMMGRYVEKVTEQKGADSIFQYVEPIFRASDYVAGN FENPVTYQKNYKQADKEIHLQTNKESVKVLKDMNFTVLNSANNHAMDYGVQGMKDTLG EFAKQNLDIVGAGYSLSDAKKKISYQKVNGVTIATLGFTDVSGKGFAAKKNTPGVLPA DPEIFIPMISEAKKHADIVVVQSHWGQEYDNDPNDRQRQLARAMSDAGADIIVGHHPH VLEPIEVYNGTVIFYSLGNFVFDQGWTRTRDSALVQYHLKKNGTGRFEVTPIDIHEAT PAPVKKDSLKQKTIIRELTKDSNFAWKVEDGKLTFDIDHSDKLKSK*" /label="capA CDS" gene complement(3079421..3080563) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /label="capA gene" CDS complement(3080582..3081031) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 15849754, 16689787, 16850406, 19734658" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 15849754, 16689787, 16850406, 19734658; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate amide ligase/translocase subunit" /protein_id="NP_391470.1" /db_xref="EnsemblGenomes-Gn:BSU35890" /db_xref="EnsemblGenomes-Tr:CAB15606" /db_xref="GOA:P96737" /db_xref="InterPro:IPR008338" /db_xref="SubtiList:BG12532" /db_xref="UniProtKB/Swiss-Prot:P96737" /translation="MFGSDLYIALILGVLLSLIFAEKTGIVPAGLVVPGYLGLVFNQP VFILLVLLVSLLTYVIVKYGLSKFMILYGRRKFAAMLITGIVLKIAFDFLYPIVPFEI AEFRGIGIIVPGLIANTIQKQGLTITFGSTLLLSGATFAIMFVYYLI*" /label="capC CDS" gene complement(3080582..3081031) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /label="capC gene" promotor_-35 3080725..3080731 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-35" upshifts 3080739 /Source="Nicolas_upshifts" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="upshifts" promotor_-10 3080745..3080763 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-10" S_feature 3080752..3082961 /Source="Nicolas_S_feature" /locus_tag="new_3699152_3701361" /HighExp="Sw, Salt, dia5, BC, B60, Diami, Lbstat, H2O2, dia15, Gly" /AntisenseName="pgsB" /AntisenseCor="7.6745622610153399E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="0.40410200000000002" /TUshortSig="SigB" /TUshortPSig="0.853" /TUlongSig="NA" /TUlongPSig="NA" /label="S1382" CDS complement(3081046..3082227) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11606194, 11751809, 12644511, 16689787, 19420703, 19734658, 27446033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (ATP-dependentamide ligase)" /protein_id="NP_391471.2" /db_xref="EnsemblGenomes-Gn:BSU35900" /db_xref="EnsemblGenomes-Tr:CAB15607" /db_xref="GOA:P96736" /db_xref="InterPro:IPR008337" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="SubtiList:BG12531" /db_xref="UniProtKB/Swiss-Prot:P96736" /translation="MWLLIIACAVILVIGILEKRRHQKNIDALPVRVNINGIRGKSTV TRLTTGILIEAGYKTVGKTTGTDARMIYWDTPEEKPIKRKPQGPNIGEQKEVMRETVE RGANAIVSECMAVNPDYQIIFQEELLQANIGVIVNVLEDHMDVMGPTLDEIAEAFTAT IPYNGHLVITDSEYTEFFKQKAKERNTKVIIADNSKITDEYLRKFEYMVFPDNASLAL GVAQALGIDEETAFKGMLNAPPDPGAMRILPLISPSEPGHFVNGFAANDASSTLNIWK RVKEIGYPTDDPIIIMNCRADRVDRTQQFANDVLPYIEASELILIGETTEPIVKAYEE GKIPADKLHDLEYKSTDEIMELLKKRMHNRVIYGVGNIHGAAEPLIEKIHEYKVKQLV S*" /label="capB CDS" gene complement(3081046..3082227) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /label="capB gene" promotor_-35 3082941..3082948 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3082963 /Source="Nicolas_upshifts" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3082964..3082983 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3082984) /Source="Nicolas_upshifts" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3082989..3083003) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3083011..3083015) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3083011..3083991 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11750820, 16519689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11750820, 16519689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ribose operon repressor (LacI family, D-ribose)" /protein_id="NP_391472.1" /db_xref="EnsemblGenomes-Gn:BSU35910" /db_xref="EnsemblGenomes-Tr:CAB15608" /db_xref="GOA:P36944" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10876" /db_xref="UniProtKB/Swiss-Prot:P36944" /translation="MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLN YYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELK KELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVK LAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQ SMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFP PLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED*" /label="rbsR CDS" gene 3083011..3083991 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /label="rbsR gene" promotor_-35 3083840..3083847 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3083861..3083880 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3083876 /Source="Nicolas_upshifts" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" CDS 3083993..3084874 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /EC_number="2.7.1.15" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 16978644; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribokinase" /protein_id="NP_391473.1" /db_xref="EnsemblGenomes-Gn:BSU35920" /db_xref="EnsemblGenomes-Tr:CAB15609" /db_xref="GOA:P36945" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR011877" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG10877" /db_xref="UniProtKB/Swiss-Prot:P36945" /translation="MRNICVIGSCSMDLVVTSDKRPKAGETVLGTSFQTVPGGKGANQ AVAAARLGAQVFMVGKVGDDHYGTAILNNLKANGVRTDYMEPVTHTESGTAHIVLAEG DNSIVVVKGANDDITPAYALNALEQIEKVDMVLIQQEIPEETVDEVCKYCHSHDIPII LNPAPARPLKQETIDHATYLTPNEHEASILFPELTISEALALYPAKLFITEGKQGVRY SAGSKEVLIPSFPVEPVDTTGAGDTFNAAFAVALAEGKDIEAALRFANRAASLSVCSF GAQGGMPTRNEVEELLS*" /label="rbsK CDS" gene 3083993..3084874 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /label="rbsK gene" CDS 3084871..3085266 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /EC_number="5.4.99.62" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 12738765, 21276853; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose pyranase" /protein_id="NP_391474.1" /db_xref="EnsemblGenomes-Gn:BSU35930" /db_xref="EnsemblGenomes-Tr:CAB15610" /db_xref="GOA:P36946" /db_xref="InterPro:IPR007721" /db_xref="InterPro:IPR023064" /db_xref="InterPro:IPR023750" /db_xref="PDB:1OGC" /db_xref="PDB:1OGD" /db_xref="PDB:1OGE" /db_xref="PDB:1OGF" /db_xref="SubtiList:BG10878" /db_xref="UniProtKB/Swiss-Prot:P36946" /translation="MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSL KPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFK LLTKDAKAVIRTGEFTPYANCILQAGVLF*" /label="rbsD CDS" gene 3084871..3085266 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /label="rbsD gene" CDS 3085282..3086763 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ATP-binding protein)" /protein_id="NP_391475.1" /db_xref="EnsemblGenomes-Gn:BSU35940" /db_xref="EnsemblGenomes-Tr:CAB15611" /db_xref="GOA:P36947" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015861" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10879" /db_xref="UniProtKB/Swiss-Prot:P36947" /translation="MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTL MNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGK EISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEV IIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTV DTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRS GEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITEN RKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHAR HLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVS SELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR*" /label="rbsA CDS" gene 3085282..3086763 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /label="rbsA gene" CDS 3086765..3087733 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (permease)" /protein_id="NP_391476.1" /db_xref="EnsemblGenomes-Gn:BSU35950" /db_xref="EnsemblGenomes-Tr:CAB15612" /db_xref="GOA:P36948" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10880" /db_xref="UniProtKB/Swiss-Prot:P36948" /translation="MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLE PLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLA IILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYG FQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTR VKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIV GTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA*" /label="rbsC CDS" gene 3086765..3087733 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /label="rbsC gene" CDS 3087745..3088662 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ribose-binding lipoprotein)" /protein_id="NP_391477.1" /db_xref="EnsemblGenomes-Gn:BSU35960" /db_xref="EnsemblGenomes-Tr:CAB15613" /db_xref="GOA:P36949" /db_xref="InterPro:IPR025997" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10881" /db_xref="UniProtKB/Swiss-Prot:P36949" /translation="MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSV STLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPT DSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGA KVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDI QAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGK LATEAADDILHGKKVQKTISAPLKLETQK*" /label="rbsB CDS" gene 3087745..3088662 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /label="rbsB gene" promotor_-35 3088671..3088677 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3088692..3088710 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3088694 /Source="Nicolas_upshifts" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="upshifts" CDS 3088744..3089280 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall binding enzyme" /protein_id="NP_391478.1" /db_xref="EnsemblGenomes-Gn:BSU35970" /db_xref="EnsemblGenomes-Tr:CAB15614" /db_xref="GOA:P96729" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR036028" /db_xref="SubtiList:BG12530" /db_xref="UniProtKB/Swiss-Prot:P96729" /translation="MNKPTKLFSTLALAAGMTAAAAGGAGTIHAQQPETTVSIDDLYS YPIDSYLVSAEALNVRTKPSASSQKADTLHLGDSLKLISFSNADWAKVKYKNGKTGFV STHYIVKAATTVKTKTKTKVYTSADGKSIKTLPADTSVSFLGWSKTNKGGFDFDWVFV DYGGTTGYMKTKDLHMTK*" /label="ywsB CDS" gene 3088744..3089280 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /label="ywsB gene" downshifts 3089263 /Source="Nicolas_upshifts" /id="D1857" /incds=0 /nref=187 /ntot=255 /MaxReadThrough="5.87246" /MaxDrop="7.38203" /score="26.4284327" /energy="-19" /TU="U2817" /idTUdmin="U2814" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature 3089308..3089418 /Source="Nicolas_S_feature" /locus_tag="new_3707708_3707818" /HighExp="Etha, M9-stat, Sw, M40t90, G150, B60, T0.30H, M0t90, T1.30H, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1383" promotor_-35 3089387..3089393 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3089408..3089419 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3089420 /Source="Nicolas_upshifts" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3089436..3089732 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11782522" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391479.1" /db_xref="EnsemblGenomes-Gn:BSU35980" /db_xref="EnsemblGenomes-Tr:CAB15615" /db_xref="InterPro:IPR024997" /db_xref="SubtiList:BG12529" /db_xref="UniProtKB/Swiss-Prot:P96728" /translation="MDQFEAAYESYKARQTTADQENVPSGKEEIIAVRRNEEDNIIAV KTNTGRELDYPTALSEAKSGKLAHVDVFHKYGRDILRSEPDGIKENNLSELPDF*" /label="ywsA CDS" gene 3089436..3089732 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /label="ywsA gene" S_feature 3089733..3090385 /Source="Nicolas_S_feature" /locus_tag="new_3708133_3708785" /HighExp="Etha, M9-stat, S5, S7, S6, Sw, S8, B60, G150, S4" /AntisenseName="ywrO" /AntisenseCor="-0.23279201478213099" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1384" CDS complement(3089772..3090299) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11782522, 14697229, 17768344; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase (unknown substrate)" /protein_id="NP_391480.1" /db_xref="EnsemblGenomes-Gn:BSU35990" /db_xref="EnsemblGenomes-Tr:CAB15616" /db_xref="GOA:P80871" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12528" /db_xref="UniProtKB/Swiss-Prot:P80871" /translation="MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEA IDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELM LAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDIS HSAKRLAEYIQQPFV*" /label="ywrO CDS" gene complement(3089772..3090299) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /label="ywrO gene" downshifts complement(3089782) /Source="Nicolas_upshifts" /id="D1858" /incds=0 /nref=48 /ntot=208 /MaxReadThrough="3.48831" /MaxDrop="4.56453" /score="1.41593376" /energy="-17.4" /TU="U2819" /idTUdmin="U2821" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3090319..3090338) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3090332) /Source="Nicolas_upshifts" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="upshifts" downshifts 3090343 /Source="Nicolas_upshifts" /id="D1859" /incds=0 /nref=26 /ntot=56 /MaxReadThrough="0.805200000000001" /MaxDrop="4.7199" /score="10.409416" /energy="-6.8" /TU="NA" /idTUdmin="U2817" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3090352..3090359) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3090398) /Source="Nicolas_upshifts" /id="D1860" /incds=0 /nref=20 /ntot=149 /MaxReadThrough="4.85403" /MaxDrop="6.46739" /score="-8.02974492" /energy="-5" /TU="U2821" /idTUdmin="U2821" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3090399..3091166) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /EC_number="4.1.1.5" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7685336, 10972805, 12363365, 17183216, 21531833, 26454865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7685336, 10972805, 12363365, 17183216, 21531833, 26454865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate decarboxylase" /protein_id="NP_391481.1" /db_xref="EnsemblGenomes-Gn:BSU36000" /db_xref="EnsemblGenomes-Tr:CAB15617" /db_xref="GOA:Q04777" /db_xref="InterPro:IPR005128" /db_xref="SubtiList:BG10472" /db_xref="UniProtKB/Swiss-Prot:Q04777" /translation="MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSE IPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTH KIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKT QPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTIS QKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE*" /label="alsD CDS" gene complement(3090399..3091166) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /label="alsD gene" CDS complement(3091228..3092940) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /EC_number="2.2.1.6" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972805, 12363365, 17183216, 7685336, 25393087, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972805, 12363365, 17183216, 7685336, 25393087, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate synthase" /protein_id="NP_391482.2" /db_xref="EnsemblGenomes-Gn:BSU36010" /db_xref="EnsemblGenomes-Tr:CAB15618" /db_xref="GOA:Q04789" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012782" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10471" /db_xref="UniProtKB/Swiss-Prot:Q04789" /translation="MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVF DALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEG DPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASA GQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVG MKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLE QADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINH IEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVT VTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGD GGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYA ESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMK TKAL*" /label="alsS CDS" gene complement(3091228..3092940) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /label="alsS gene" promotor_-35 3091839..3091848 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3091862..3091881 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3091862 /Source="Nicolas_upshifts" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3092994..3093013) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3092999) /Source="Nicolas_upshifts" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3093019..3093026 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3093028..3093032) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3093040..3093059 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3093050 /Source="Nicolas_upshifts" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="upshifts" CDS 3093098..3094006 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling alsSD, ictEP expression (LysR family)" /protein_id="NP_391483.1" /db_xref="EnsemblGenomes-Gn:BSU36020" /db_xref="EnsemblGenomes-Tr:CAB15619" /db_xref="GOA:Q04778" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10470" /db_xref="UniProtKB/Swiss-Prot:Q04778" /translation="MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVG VTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSAT YEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETA QSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPN IVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDN HNPLIKHFIHISNCQQTRTKESDAGT*" /label="alsR CDS" gene 3093098..3094006 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /label="alsR gene" promotor_-35 3094074..3094082 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3094084..3094216 /Source="Nicolas_S_feature" /locus_tag="new_3712484_3712616" /HighExp="BT, S8, B36, S7, G/S, S6, Pyr, B60, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.14666000000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.896, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1385" upshifts 3094084 /Source="Nicolas_upshifts" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3094096..3094115 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3094217..3095545 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/H+ antiporter" /protein_id="NP_391484.1" /db_xref="EnsemblGenomes-Gn:BSU36030" /db_xref="EnsemblGenomes-Tr:CAB15620" /db_xref="GOA:O05224" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12527" /db_xref="UniProtKB/Swiss-Prot:O05224" /translation="MLAFFVTMIFIFWRPKGLNEAIPATFGALMVLLCGSVSLADLGE IGTKVTGASVTILATMIMAIALESFGFFYWVAAKLLQQSKGSGIKLFWLTNLLCFLMT IFLNNDGSILITTPILLLVLKYLGLKKHQKAPYLLSGVLIATASSAPIGVSNIVNLIS LKIIGMDLYLHTAMMFVPSMMGLIFMTCLLFMFFYKRLPKSLPDIPGHFQSLRHRRYH PLHSPSAPLPERNQTKIMLFVLAFVFLVRMSLFAASYTGISVPLVAVIGSFILLSWRW IYFKTSPRDLLYKSPWHIFIFAFTMYVLIYGLHNIGFTELLVSYFEPVVSGSLAHATF ASGISTSVFSNLFNNHPALMISTFTLTEMTLNPSTTKIIYLANIIGSDIGSLLLPMGT LATLIWMHILKQHDESISWGEYIKTTIIIIPLTVLFTLTCLYFWISWLFL*" /label="ywrK CDS" gene 3094217..3095545 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /label="ywrK gene" downshifts 3095536 /Source="Nicolas_upshifts" /id="D1861" /incds=0 /nref=16 /ntot=32 /MaxReadThrough="1.63489" /MaxDrop="6.12455" /score="-6.14091334" /energy="-11.9" /TU="NA" /idTUdmin="U2823" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3095602..3096279) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14762006, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391485.1" /db_xref="EnsemblGenomes-Gn:BSU36040" /db_xref="EnsemblGenomes-Tr:CAB15621" /db_xref="InterPro:IPR020139" /db_xref="InterPro:IPR020173" /db_xref="SubtiList:BG12526" /db_xref="UniProtKB/Swiss-Prot:O05223" /translation="MKGLNQFLNTDVEVVISGDTRFVGTLIDIGQDIFVIFDGCNYLY IPLLHLHQINKAKIVTSTEKPFLINPEDPMIEAETQAFSYRNTLNKVKGQFIEVYVTG GRSIHGYVTNVLNDYIVFFSPVFKILFISMHHLKWFTPYSTEQTPYTLDNSQLPVVPS KVPLVRNFEEQIKKNIGELVIFDMGEVPEKVGLLKGVSNNIIELINASGEPVIWKLNH LKTMHLP*" /label="ywrJ CDS" gene complement(3095602..3096279) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /label="ywrJ gene" downshifts complement(3095612) /Source="Nicolas_upshifts" /id="D1862" /incds=0 /nref=14 /ntot=28 /MaxReadThrough="1.74629" /MaxDrop="5.1172" /score="-4.02447737" /energy="-9.5" /TU="NA" /idTUdmin="U2824" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3096339..3097481) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8755863, 10559171, 11737650, 14762006, 19933362, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755863, 10559171, 11737650, 14762006, 19933362, 27185916; Product type s : structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_391486.1" /db_xref="EnsemblGenomes-Gn:BSU36050" /db_xref="EnsemblGenomes-Tr:CAB15622" /db_xref="GOA:P07789" /db_xref="SubtiList:BG10491" /db_xref="UniProtKB/Swiss-Prot:P07789" /translation="MSKRRMKYHSNNEISYYNFLHSMKDKIVTVYRGGPESKKGKLTA VKSDYIALQAEKKIIYYQLEHVKSITEDTNNSTTTIETEEMLDADDFHSLIGHLINQS VQFNQGGPESKKGRLVWLGDDYAALNTNEDGVVYFNIHHIKSISKHEPDLKIEEQTPV GVLEADDLSEVFKSLTHKWVSINRGGPEAIEGILVDNADGHYTIVKNQEVLRIYPFHI KSISLGPKGSYKKEDQKNEQNQEDNNDKDSNSFISSKSYSSSKSSKRSLKSSDDQSSK SGRSSRSKSSSKSSKRSLKSSDYQSSKSGRSSRSKSSSKSSKRSLKSSDYQSSKSSKR SPRSSDYQSSRSPGYSSSIKSSGKQKEDYSYETIVRTIDYHWKRKF*" /label="cotB CDS" gene complement(3096339..3097481) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /label="cotB gene" promotor_-10 complement(3097518..3097537) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3097526) /Source="Nicolas_upshifts" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3097528..3097608) /Source="Nicolas_S_feature" /locus_tag="new_3715928_3716008_c" /HighExp="S6, S7, S8, S5, BT, B36, S4, G/S, Pyr, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1386" promotor_-35 complement(3097551..3097559) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3097609..3098697) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762006, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762006, 25115591, 27185916; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein kinase" /protein_id="NP_391487.1" /db_xref="EnsemblGenomes-Gn:BSU36060" /db_xref="EnsemblGenomes-Tr:CAB15623" /db_xref="GOA:Q45535" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG11791" /db_xref="UniProtKB/Swiss-Prot:Q45535" /translation="MKNQSNLPLYQLFVHPKDLRELKKDIWDDDPVPAVMKVNQKRLD IDIAYRGSHIRDFKKKSYHISFYQPKTFRGAREIHLNAEYKDPSLMRNKLSLDFFSEL GTLSPKAEFAFVKMNGKNEGVYLELESVDEYYLAKRKLADGAIFYAVDDDANFSLMSD LERETKTSLELGYEKKTGTEEDDFYLQDMIFKINTVPKAQFKSEVTKHVDVDKYLRWL AGIVFTSNYDGFVHNYALYRSGETGLFEVIPWDYDATWGRDIHGERMAADYVRIQGFN TLTARILDESEFRKSYKRLLEKTLQSLFTIEYMEPKIMAMYERIRPFVLMDPYKKNDI ERFDREPDVICEYIKNRSQYLKDHLSIL*" /label="cotH CDS" gene complement(3097609..3098697) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /label="cotH gene" S_feature complement(3098698..3098811) /Source="Nicolas_S_feature" /locus_tag="new_3717098_3717211_c" /HighExp="S6, S8, S7, S5, BT, B36, Pyr, G/S, S4, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1387" promotor_-35 3098753..3098762 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3098775..3098794 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3098788 /Source="Nicolas_upshifts" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3098811) /Source="Nicolas_upshifts" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3098815..3098829) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3098838..3098842) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3098838..3099425 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14762006, 15621419, 22720735, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14762006, 15621419, 22720735, 25115591, 27185916; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore morphogenetic protein" /protein_id="NP_391488.1" /db_xref="EnsemblGenomes-Gn:BSU36070" /db_xref="EnsemblGenomes-Tr:CAB15624" /db_xref="GOA:P39801" /db_xref="SubtiList:BG11017" /db_xref="UniProtKB/Swiss-Prot:P39801" /translation="MGHYSHSDIEEAVKSAKKEGLKDYLYQEPHGKKRSHKKSHRTHK KSRSHKKSYCSHKKSRSHKKSFCSHKKSRSHKKSYCSHKKSRSHKKSYRSHKKSRSYK KSYRSYKKSRSYKKSCRSYKKSRSYKKSYCSHKKKSRSYKKSCRTHKKSYRSHKKYYK KPHHHCDDYKRHDDYDSKKEYWKDGNCWVVKKKYK*" /label="cotG CDS" gene 3098838..3099425 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /label="cotG gene" CDS 3098926..3099405 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /function="14.1: Surface structures" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="doubtful CDS (putative in frame frameshift)" /protein_id="YP_009514005.1" /translation="MEKNAVIKSRTALTKNLAAIKNHTALTKNLAVTKNHSVLTKNLA ATKNHTALTRNLAATKNRTVLTKNLAAIKNLTVLTKNLVAIKNLAVLTKNLAATKSLT VLTRKNLAAIRSHAAHTKNLIVPIRNTTKNRTTTATTTKDTMIMTAKKNTGKTAIAG* " /label="doubtful CDS (putative in frame frameshift)" gene 3098926..3099405 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /label="gene" S_feature complement(3099309..3099506) /Source="Nicolas_S_feature" /locus_tag="new_3717709_3717906_c" /HighExp="S5, S6, S4, B60, S3, nit, G/S, SMMPr, S8, ferm" /AntisenseName="cotG" /AntisenseCor="0.60092819988141299" /AntisenseRegPval="-27.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1388" downshifts 3099342 /Source="Nicolas_upshifts" /id="D1863" /incds=1 /nref=1 /ntot=54 /MaxReadThrough="7.80801" /MaxDrop="2.7794" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(3099352) /Source="Nicolas_upshifts" /id="D1864" /incds=1 /nref=3 /ntot=23 /MaxReadThrough="4.99409" /MaxDrop="6.67733" /score="-1.37249416" /energy="-5.2" /TU="U2827" /idTUdmin="U2824" /TUdmin="-3740" /isTUend="FALSE" /label="downshifts" downshifts 3099411 /Source="Nicolas_upshifts" /id="D1865" /incds=0 /nref=41 /ntot=80 /MaxReadThrough="4.68169" /MaxDrop="5.35584" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts 3099490 /Source="Nicolas_upshifts" /id="D1866" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="2.30708" /MaxDrop="3.92552" /score="17.1895651" /energy="-10.7" /TU="NA" /idTUdmin="U2825" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3099505..3099524) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3099511) /Source="Nicolas_upshifts" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3099533..3099540 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3099537..3099546) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3099555..3099574 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3099561 /Source="Nicolas_upshifts" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="upshifts" CDS 3099599..3100216 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /EC_number="1.14.13.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-binding monooxygenase" /protein_id="NP_391489.1" /db_xref="EnsemblGenomes-Gn:BSU36080" /db_xref="EnsemblGenomes-Tr:CAB15625" /db_xref="GOA:O05220" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12525" /db_xref="UniProtKB/Swiss-Prot:O05220" /translation="MYIFQADQLSAKDTYKLLSGTVIPRPIAFVTTLSSGGAVNAAPF SFYNVVSSDPPLLSISVNRTEGRQKDTARNAVENGEFVVHVSDEAIIEDINETAASLR PDESELTRTSLHPVESKAVSVPGIKEARVRFECKLERHITFDNDQGITTADLLIGRVV CFHLDEKVYDAEKGYILTDELKPASRLAGNHYAKLGEEFTLIRPS*" /label="ywrF CDS" gene 3099599..3100216 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /label="ywrF gene" S_feature 3100217..3100317 /Source="Nicolas_S_feature" /locus_tag="new_3718617_3718717" /HighExp="Etha, dia5, Diami, dia15, Lbtran, LBGtran, LPhT, M40t45, M40t90, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1389" downshifts 3100274 /Source="Nicolas_upshifts" /id="D1867" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="4.52989" /MaxDrop="4.48979" /score="-1.9002322" /energy="-14.9" /TU="U2828" /idTUdmin="U2828" /TUdmin="-454" /isTUend="FALSE" /label="downshifts" promotor_-35 3100343..3100352 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3100364..3100379 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3100365 /Source="Nicolas_upshifts" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3100394..3100729 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391490.1" /db_xref="EnsemblGenomes-Gn:BSU36090" /db_xref="EnsemblGenomes-Tr:CAB15626" /db_xref="GOA:O05219" /db_xref="InterPro:IPR025441" /db_xref="SubtiList:BG12524" /db_xref="UniProtKB/Swiss-Prot:O05219" /translation="MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKW IEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMF MLLIYVCTL*" /label="ywrE CDS" gene 3100394..3100729 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /label="ywrE gene" promotor_-10 complement(3100685..3100703) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3100694) /Source="Nicolas_upshifts" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3100718..3100723) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3100728 /Source="Nicolas_upshifts" /id="D1868" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="5.64855" /MaxDrop="3.64569" /score="-1.9002322" /energy="-14.9" /TU="U2829" /idTUdmin="U2828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3100734..3102311) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /EC_number="3.5.1.126" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12823818, 14762019, 19935659, 27303801, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxamate amidohydrolase" /protein_id="NP_391491.1" /db_xref="EnsemblGenomes-Gn:BSU36100" /db_xref="EnsemblGenomes-Tr:CAB15627" /db_xref="GOA:O05218" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="SubtiList:BG12523" /db_xref="UniProtKB/Swiss-Prot:O05218" /translation="MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACL AVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSA ITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSY MTIDDFKAHRGEWAAPVSSDYRGYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSF EYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLAEEIGYLAIPAESRP VGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTL EPRKRTFHTLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEP RWVWGRTWGEEYEGLRVEGRFTDKTIQKLKDSGHLVEVVGDYDPLMGQAAAIKVDEEG FLQGGADPRGDGAAVGI*" /label="hpxW CDS" gene complement(3100734..3102311) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /label="hpxW gene" S_feature 3100773..3102484 /Source="Nicolas_S_feature" /locus_tag="new_3719173_3720884" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T-0.40H, T0.0H, Salt" /AntisenseName="ywrD" /AntisenseCor="0.153519829066777" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1390" promotor_-35 3102462..3102469 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3102480..3102499 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3102486 /Source="Nicolas_upshifts" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3102525..3103001 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23989926; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional negative regulator of chromate transport (Lrp/AsnC family)" /protein_id="NP_391492.1" /db_xref="EnsemblGenomes-Gn:BSU36110" /db_xref="EnsemblGenomes-Tr:CAB15628" /db_xref="GOA:O05217" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12522" /db_xref="UniProtKB/Swiss-Prot:O05217" /translation="MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVA VQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTS LYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL*" /label="chrS CDS" gene 3102525..3103001 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /label="chrS gene" CDS 3103015..3103608 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit N" /protein_id="NP_391493.1" /db_xref="EnsemblGenomes-Gn:BSU36120" /db_xref="EnsemblGenomes-Tr:CAB15629" /db_xref="GOA:O05216" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12521" /db_xref="UniProtKB/Swiss-Prot:O05216" /translation="MKNHPYRDMTAAMVRTGILGFGGGPSVIPLIRHEAVNKYKWIDD DEFGEILAIANALPGPIATKMAAYLGFKLKGTLGAIVAILAHILPTCLAMVGLFAAVN VLSHSAIVAGMIGAVTPVIAVMLGIMAYEFGQKALKGFGWVTGILFFIIAFIGLQTLQ INPGLVIIIFLAYGAFHFKLKDKITNKHSKDKGMSAS*" /label="chrB CDS" gene 3103015..3103608 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /label="chrB gene" CDS 3103605..3104141 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit C" /protein_id="NP_391494.1" /db_xref="EnsemblGenomes-Gn:BSU36130" /db_xref="EnsemblGenomes-Tr:CAB15630" /db_xref="GOA:O05215" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12520" /db_xref="UniProtKB/Swiss-Prot:O05215" /translation="MISIYLFMAFFIANLLGYGGGPASIPLMFEEVVNRYSWLSNDQF SNMLALANALPGPIATKIAAYVGYSAGGWPGFLIALIATVVPSALALIVLLRIIQRFR QSPVIKGMTLSVQPVIAVMMLILTWQIGADGIKAIGWVQSIVITGISLLAMTKFKMHP AFLIIAAFLYGGLVIPYL*" /label="chrA CDS" gene 3103605..3104141 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /label="chrA gene" downshifts 3104122 /Source="Nicolas_upshifts" /id="D1869" /incds=0 /nref=4 /ntot=90 /MaxReadThrough="0.0513700000000004" /MaxDrop="3.46649" /score="29.5508265" /energy="-8.6" /TU="NA" /idTUdmin="U2829" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(3104168..3104389) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391495.1" /db_xref="EnsemblGenomes-Gn:BSU36140" /db_xref="EnsemblGenomes-Tr:CAB15631" /db_xref="SubtiList:BG12519" /db_xref="UniProtKB/Swiss-Prot:P96727" /translation="MKFLLSVIAGLLILALYLFWKVQPPVWIQVETNSSQLKQSVRMA GTTLQVKHMIKSDAGEETAVISNGISGLK*" /label="ywqO CDS" gene complement(3104168..3104389) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /label="ywqO gene" upshifts 3104336 /Source="Nicolas_upshifts" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3104343..3104344 /Source="Nicolas_upshift_promotors" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3104386..3104931) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391496.1" /db_xref="EnsemblGenomes-Gn:BSU36150" /db_xref="EnsemblGenomes-Tr:CAB15632" /db_xref="GOA:P96726" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLI" /db_xref="SubtiList:BG12518" /db_xref="UniProtKB/Swiss-Prot:P96726" /translation="MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIED LRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPR FPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGD ILRDHQALSAASRLLKRSDAI*" /label="ywqN CDS" gene complement(3104386..3104931) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /label="ywqN gene" promotor_-35 3104948..3104955 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3104970..3104989 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3104974 /Source="Nicolas_upshifts" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="upshifts" CDS 3105054..3105935 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391497.1" /db_xref="EnsemblGenomes-Gn:BSU36160" /db_xref="EnsemblGenomes-Tr:CAB15633" /db_xref="GOA:P96725" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12517" /db_xref="UniProtKB/Swiss-Prot:P96725" /translation="MELKQLITFITAAEHVNFTLTAKMLNYAQSSVTSQIKSLEEEIG TPLFERLGKRLILTEAGKTFKSYAQKIIALTEEAKMATNQVRETTGTLKIGATESQCT YRLPPIIKEFKQAFPQVKLIFKPYISNEQAKEQLLQGQLDITFILDVNRMEDALHVES LIQDEIKMVAANDHPFPADLPVTLKDLQNETLLLTEDGCSYRTLFENNLHDSGIYPNK LEFVSIEAIKQCVMAGLGIGILPEMTVKDDIAAGRMKELNWQSDCPVFTQLAWHKDKW MSAPLKAFIDLTRKTFK*" /label="ywqM CDS" gene 3105054..3105935 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /label="ywqM gene" CDS complement(3106020..3106736) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /EC_number="3.1.21.7" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1692969, 22056936, 27530626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1692969, 22056936, 27530626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease V" /protein_id="NP_391498.2" /db_xref="EnsemblGenomes-Gn:BSU36170" /db_xref="EnsemblGenomes-Tr:CAB15634" /db_xref="GOA:P96724" /db_xref="InterPro:IPR007581" /db_xref="PDB:3GA2" /db_xref="SubtiList:BG12516" /db_xref="UniProtKB/Swiss-Prot:P96724" /translation="MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAG VDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEA AKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEI EVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIP VRLADLETHVLRTFYQKNHV*" /label="nfi CDS" gene complement(3106020..3106736) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /label="nfi gene" downshifts complement(3106040) /Source="Nicolas_upshifts" /id="D1870" /incds=0 /nref=44 /ntot=216 /MaxReadThrough="1.91774" /MaxDrop="3.62442" /score="12.1019223" /energy="-7.4" /TU="NA" /idTUdmin="U2834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3106746..3107210) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease antitoxin" /protein_id="NP_391499.1" /db_xref="EnsemblGenomes-Gn:BSU36180" /db_xref="EnsemblGenomes-Tr:CAB15635" /db_xref="InterPro:IPR011652" /db_xref="SubtiList:BG12515" /db_xref="UniProtKB/Swiss-Prot:P96723" /translation="MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGL AYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRK KSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE*" /label="rttO CDS" gene complement(3106746..3107210) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /label="rttO gene" CDS complement(3107200..3109008) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /EC_number="3.1.-.-" /function="15.8: Toxin production and resistance" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease toxin" /protein_id="NP_391500.1" /db_xref="EnsemblGenomes-Gn:BSU36190" /db_xref="EnsemblGenomes-Tr:CAB15636" /db_xref="GOA:P96722" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR025968" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG12514" /db_xref="UniProtKB/Swiss-Prot:P96722" /translation="MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDN FKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNGISGDIKDQELNDSYVETSFLDH ELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSV IEVENQGTTYIDAKTQQAEARRLQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKR ATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGKAIYKTGKAAIAAEH ALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAIT IIGGAGLAHYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKE DLHHRINLRAEVLNELSRIKSSGLTKKQRGPAVAGVLDKKTGNYYFGINNIDGKPPKV LHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMVYVVSAR KINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK*" /label="rttN CDS" gene complement(3107200..3109008) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /label="rttN gene" CDS complement(3109027..3109287) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391501.1" /db_xref="EnsemblGenomes-Gn:BSU36200" /db_xref="EnsemblGenomes-Tr:CAB15637" /db_xref="InterPro:IPR020299" /db_xref="SubtiList:BG12513" /db_xref="UniProtKB/Swiss-Prot:P96721" /translation="MSEIKLKYDTVIKTLDSVKDALADVSIGAAGSNGKNSLDYTKKY HEREENIKTMLGDYKKAVQKNIEDTKDNVDSLKEQDEAIAVK*" /label="ywqI CDS" gene complement(3109027..3109287) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /label="ywqI gene" CDS complement(3109297..3109719) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15101989" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391502.1" /db_xref="EnsemblGenomes-Gn:BSU36210" /db_xref="EnsemblGenomes-Tr:CAB15638" /db_xref="InterPro:IPR020326" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG12512" /db_xref="UniProtKB/Swiss-Prot:P96720" /translation="MGYESMLADIKSSLNGKISDVEDKIEKLKKAKKDIDTLQEEAIT EIKEIVKPELGKHWTGTKADDFDKGREEAKSEASKIVNDKYNEYMASINGKIFDLEWD KAKYASELFIANGAADLLKKGEEFAEEVGNTISKLKWW*" /label="ywqH CDS" gene complement(3109297..3109719) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /label="ywqH gene" S_feature complement(3109720..3109802) /Source="Nicolas_S_feature" /locus_tag="new_3728120_3728202_c" /HighExp="T2.30H, T4.0H, T5.0H, T3.0H, T3.30H, T1.30H, T2.0H, S4, T-0.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1391" promotor_-10 complement(3109794..3109813) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3109802) /Source="Nicolas_upshifts" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3109826..3109833) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3109936..3110061) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514006.1" /translation="MTKSDMADQMKNINMNNKLSAERGRSTTSASFKCLYNYDIR*" /label="hypothetical protein CDS" gene complement(3109936..3110061) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /label="gene" S_feature complement(3109979..3110110) /Source="Nicolas_S_feature" /locus_tag="new_3728379_3728510_c" /HighExp="HiOs, BI, M9-tran, T-2.40H, MG 150, Sw, M9-exp, S1, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19133600000000001" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1392" downshifts complement(3110022) /Source="Nicolas_upshifts" /id="D1871" /incds=0 /nref=29 /ntot=208 /MaxReadThrough="3.03928" /MaxDrop="3.47153" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2835" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3110111..3110896) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391503.1" /db_xref="EnsemblGenomes-Gn:BSU36220" /db_xref="EnsemblGenomes-Tr:CAB15639" /db_xref="InterPro:IPR015315" /db_xref="InterPro:IPR035948" /db_xref="PDB:1PV5" /db_xref="SubtiList:BG12511" /db_xref="UniProtKB/Swiss-Prot:P96719" /translation="MNHLPEKMRPYRDLLEKSAKEYVKLNVRKGKTGRYDSKIAGDPY FPKHETYPTDENGQPMKLLAQINFSHIPQLDGYPSSGILQFYISVHDDVYGLNFDDRC EQKNFRVIYFENIVENDDELVSDFSFIGTGECDFPILSEAAVEPVKSSEWVLPTDFQF EQYTGMETMEFFGQFGEDEEDIYNELAENGFGHKIGGYASFTQHDPREYAYKEHTIML LQIDSDDDIDSMWGDVGIANFFITPEDLRKKDFSNVLYNWDCS*" /label="ywqG CDS" gene complement(3110111..3110896) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /label="ywqG gene" S_feature complement(3110897..3111012) /Source="Nicolas_S_feature" /locus_tag="new_3729297_3729412_c" /HighExp="HiOs, T-1.40H, T-2.40H, T-3.40H, M9-tran, MG 150, SMM, GM 150, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1393" promotor_-10 complement(3111005..3111024) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3111012) /Source="Nicolas_upshifts" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3111038..3111045) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3111088..3112410) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 15866923, 16415592" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 15866923, 16415592; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose dehydrogenase" /protein_id="NP_391504.1" /db_xref="EnsemblGenomes-Gn:BSU36230" /db_xref="EnsemblGenomes-Tr:CAB15640" /db_xref="GOA:P96718" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12510" /db_xref="UniProtKB/Swiss-Prot:P96718" /translation="MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGIS PIFEPGLEELMRKNTADGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDA AKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFI NEISNICEKVGADIEAVAYGMGQDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVE HDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVI ADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQF PLAAYQDLMETPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ*" /label="uglF CDS" gene complement(3111088..3112410) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /label="uglF gene" downshifts complement(3111100) /Source="Nicolas_upshifts" /id="D1872" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.29767" /MaxDrop="6.20721" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2836" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3112444) /Source="Nicolas_upshifts" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3112446..3112571) /Source="Nicolas_S_feature" /locus_tag="new_3730846_3730971_c" /HighExp="dia15, H2O2, Diami, dia5, LBGstat, Paraq, LBGexp, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13453899999999999" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1394" promotor_-10 complement(3112446..3112464) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3112480..3112485) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3112551..3112570) /Source="Nicolas_upshift_promotors" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3112571) /Source="Nicolas_upshifts" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3112605..3113369) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15866923, 16415592, 16549871, 21605684, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15866923, 16415592, 16549871, 21605684, 27148221; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine-phosphatase" /protein_id="NP_391505.1" /db_xref="EnsemblGenomes-Gn:BSU36240" /db_xref="EnsemblGenomes-Tr:CAB15641" /db_xref="GOA:P96717" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR016667" /db_xref="PDB:3QY6" /db_xref="PDB:3QY7" /db_xref="SubtiList:BG12509" /db_xref="UniProtKB/Swiss-Prot:P96717" /translation="MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHN NGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDT KYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAAS QITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGS ELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF*" /label="ptpZ CDS" gene complement(3112605..3113369) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /label="ptpZ gene" downshifts complement(3113388) /Source="Nicolas_upshifts" /id="D1873" /incds=0 /nref=4 /ntot=152 /MaxReadThrough="3.17433" /MaxDrop="3.31415" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(3113422..3114135) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /EC_number="2.7.10.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maintenance protein tyrosine kinase involved in biofilm formation" /protein_id="NP_391506.1" /db_xref="EnsemblGenomes-Gn:BSU36250" /db_xref="EnsemblGenomes-Tr:CAB15642" /db_xref="GOA:P96716" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12508" /db_xref="UniProtKB/Swiss-Prot:P96716" /translation="MALRKNRGSRMQRNVIAMTEPKSLNSEQYRTIRTNIEFASVDRQ MKSVMITSACPGEGKSTTAANLAVVFAQQGKKVLLIDADLRKPTVHTAFFLENTVGLT SVLLKKSSMEQAVQASNEKHLDVLTSGPIPPNPAELLSSKWMKELAYEACAAYDMVIF DTPPILAVADAQILGNVADGSVLVISSGKTEKEQAAKAKEALATCKSKLLGAIMNGKK LSKHSEYGYYGTKDNFMQK*" /label="ptkA CDS" gene complement(3113422..3114135) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /label="ptkA gene" downshifts complement(3113439) /Source="Nicolas_upshifts" /id="D1874" /incds=0 /nref=10 /ntot=157 /MaxReadThrough="4.4352" /MaxDrop="4.08842" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-381" /isTUend="FALSE" /label="downshifts" CDS complement(3114125..3114871) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 23939619, 24493247, 26283769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 23939619, 24493247, 26283769; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of PtkA protein tyrosine kinase activity; modulation of biofilm formation" /protein_id="NP_391507.1" /db_xref="EnsemblGenomes-Gn:BSU36260" /db_xref="EnsemblGenomes-Tr:CAB15643" /db_xref="GOA:P96715" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR032807" /db_xref="SubtiList:BG12507" /db_xref="UniProtKB/Swiss-Prot:P96715" /translation="MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIY ENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQE LNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKA EVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLG TVSTIANEQKTAKTLQGFQSEKTGSGHFGA*" /label="tkmA CDS" gene complement(3114125..3114871) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /label="tkmA gene" promotor_-10 complement(3114903..3114922) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3114915) /Source="Nicolas_upshifts" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3114939..3114942) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3115105..3115248) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097792.1" /db_xref="EnsemblGenomes-Gn:BSU36269" /db_xref="EnsemblGenomes-Tr:CAX52703" /db_xref="UniProtKB/Swiss-Prot:C0H3S3" /translation="MSEKKLNQEEFLKILMHAHEIGEQSSEMTTKEMLENLISHIKNG YAT*" /label="ywzD CDS" gene complement(3115105..3115248) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /label="ywzD gene" downshifts complement(3115126) /Source="Nicolas_upshifts" /id="D1875" /incds=0 /nref=221 /ntot=264 /MaxReadThrough="2.76798" /MaxDrop="8.13076" /score="15.8630799" /energy="-9.3" /TU="U2839" /idTUdmin="U2841" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3115249..3115334) /Source="Nicolas_S_feature" /locus_tag="new_3733649_3733734_c" /HighExp="S6, S8, S7, MG-0.2, S5, M9-stat, MG-0.1, MG 25, T0.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD, SigK" /TUshortPSig="0.275, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1395" misc_feature complement(3115324..3115335) /Source="Nicolas_upshift_promotors" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3115334) /Source="Nicolas_upshifts" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3115336..3115566) /Source="Nicolas_S_feature" /locus_tag="new_3733736_3733966_c" /HighExp="S6, S8, S7, S5, BT, Cold, LBGstat, LPhT, Pyr, C30" /AntisenseName="ywqB" /AntisenseCor="3.4267833233812203E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1396" promotor_-35 3115373..3115377 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3115393..3115412 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3115402 /Source="Nicolas_upshifts" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="upshifts" CDS 3115452..3117062 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative replication initiation protein" /protein_id="NP_391508.2" /db_xref="EnsemblGenomes-Gn:BSU36270" /db_xref="EnsemblGenomes-Tr:CAB15644" /db_xref="GOA:P96714" /db_xref="InterPro:IPR007527" /db_xref="SubtiList:BG12506" /db_xref="UniProtKB/Swiss-Prot:P96714" /translation="MLQNMISKDDVLASAEQLKELLPYNEENVQLIKKALILYRQDSV YRLQAVSPTEVTAYVQDVVPVRVTLNLFVIVKSGCSCPSGRICRHMLAVFLYVYAMFE RVGTFTEYWLEREKLEESKELVRRQFQEKVLPNEESLSSWLAFFDSEFSLWQARTPEG SQNMQGLYYGYLSALKKHAPNKPELKSLYQIHSAIAVWLRMFTLIEAGKLNPEQDFYS LNPYVEQLMDTIYSSIDKLKTYALSFALDPFLDKTPDVIRHLLLKEEIFQYERIRVFG EIWSALLSRPKWVAREQEILKKEAGRRFSPELQFGRLHLEFLQKNDDVIFEEADQFPP EALPYTFQWLSEMTAKKDWKRLKTWYQQIEPIAMGYTKLDKPFKEIRDVIGELFLLLN AYVQQTNDQALFERFAAGCLPYTFTEYSHHLYEKKRYAEWIEIHSLVGFSINEMDKMM LKEIAASDPEALIPAYHREVAFFIDQKNRSSYKEAARYLKKLRTLYKKAKKQKVWERY IQLLSSHYKRLRALQEELQKGKLIDGES*" /label="ywqB CDS" gene 3115452..3117062 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /label="ywqB gene" promotor_-10 complement(3115554..3115572) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3115566) /Source="Nicolas_upshifts" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3115568..3115742) /Source="Nicolas_S_feature" /locus_tag="new_3733968_3734142_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, B60, C30" /AntisenseName="ywqB" /AntisenseCor="-0.10880748846525" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1397" promotor_-35 complement(3115586..3115593) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3115729..3115748) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3115742) /Source="Nicolas_upshifts" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3115762..3115770) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3117049..3119817 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9507009, 9614128, 11751638, 17913745, 19282450; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATPase involved in RNA remodelling DNA recombination and repair" /protein_id="NP_391509.1" /db_xref="EnsemblGenomes-Gn:BSU36280" /db_xref="EnsemblGenomes-Tr:CAB15645" /db_xref="GOA:P94593" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR022138" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12505" /db_xref="UniProtKB/Swiss-Prot:P94593" /translation="MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWH ESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTI YEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEH IKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRD KKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFL SEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFAT NGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILAR ELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTL RPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPT SVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELS SVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNK GYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEK EFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQ TELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNG SLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATD RAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEEL FTLSATAQ*" /label="hepA CDS" gene 3117049..3119817 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /label="hepA gene" downshifts complement(3119866) /Source="Nicolas_upshifts" /id="D1876" /incds=0 /nref=9 /ntot=202 /MaxReadThrough="1.80101" /MaxDrop="4.14573" /score="30.708119" /energy="-14.4" /TU="U2843" /idTUdmin="U2844" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3119943..3120800) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25848029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase of unidentified specificity (possibly promiscuous)" /protein_id="NP_391510.1" /db_xref="EnsemblGenomes-Gn:BSU36290" /db_xref="EnsemblGenomes-Tr:CAB15646" /db_xref="GOA:P94592" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:1NRW" /db_xref="SubtiList:BG12504" /db_xref="UniProtKB/Swiss-Prot:P94592" /translation="MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRA HFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYE VFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQEL FEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQAL KRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHG VAHMMKHLL*" /label="ywpJ CDS" gene complement(3119943..3120800) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /label="ywpJ gene" CDS complement(3120806..3121582) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11491085" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11491085; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (glucose repression ofcatabolic operons)" /protein_id="NP_391511.1" /db_xref="EnsemblGenomes-Gn:BSU36300" /db_xref="EnsemblGenomes-Tr:CAB15647" /db_xref="GOA:P94591" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12503" /db_xref="UniProtKB/Swiss-Prot:P94591" /translation="MYQEERLVAILDFLKQHNRITTEQICTLLQVSRDTARRDLVKLE EQNAIIRTRGGAILPTVHQKIQSYSGRLKTVSEEKNKIGRLAASLIHDGDRVILDAST TVQACAKHLNAVDCTVITNSINLADVLSDKEGIEIYLLGGKLEKEHRFLYGSSVIEKL SSYHVDKALIGVVGISEHGITIAHEEDGMVKRKMIQQAKQVIALADHSKLGSTSFYQY AELNEIDLLITDRLPNQAFCDLLDRNGVELLVTEQDEGKD*" /label="glcR CDS" gene complement(3120806..3121582) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /label="glcR gene" promotor_-10 complement(3121608..3121627) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3121630) /Source="Nicolas_upshifts" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3121632..3121704) /Source="Nicolas_S_feature" /locus_tag="new_3740032_3740104_c" /HighExp="C30, GM 150, T-4.40H, G/S, C90, S2, T-5.40H, T-3.40H, T-2.40H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1398" promotor_-35 complement(3121642..3121649) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3121706..3121805) /Source="Nicolas_S_feature" /locus_tag="new_3740106_3740205_c" /HighExp="HiOs, S2, T-3.40H, T0.30H, C90, G/S, T1.0H, T0.0H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1399" downshifts complement(3121749) /Source="Nicolas_upshifts" /id="D1877" /incds=0 /nref=221 /ntot=258 /MaxReadThrough="3.81096" /MaxDrop="7.17295" /score="-7.00620083" /energy="-7.5" /TU="U2844" /idTUdmin="U2846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(3121806..3122147) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762004, 16009133, 16549871, 17630974, 25138221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762004, 16009133, 16549871, 17630974, 25138221; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391512.2" /db_xref="EnsemblGenomes-Gn:BSU36310" /db_xref="EnsemblGenomes-Tr:CAB15648" /db_xref="GOA:C0SPB6" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="PDB:3VDY" /db_xref="SubtiList:BG12502" /db_xref="UniProtKB/Swiss-Prot:C0SPB6" /translation="MFNQVMLVGRLTKDPDLRYTSAGAAVAHVTLAVNRSFKNASGEI EADYVNCTLWRKTAENTALYCQKGSLVGVSGRIQTRSYENEEGVNVYVTEVLADTVRF MDPKPREKAAD*" /label="ssbB CDS" gene complement(3121806..3122147) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /label="ssbB gene" promotor_-10 complement(3122169..3122188) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3122188) /Source="Nicolas_upshifts" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3122202..3122209) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3122224..3122607) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="interaction partner of DynA" /protein_id="NP_391513.1" /db_xref="EnsemblGenomes-Gn:BSU36320" /db_xref="EnsemblGenomes-Tr:CAB15649" /db_xref="SubtiList:BG12501" /db_xref="UniProtKB/Swiss-Prot:P94589" /translation="MNQFRLKEIYIDGVPSESHLIQKEVTYMLSRKEVFEVHLNKKGR ISFLYETQDGMEQYKIKLSMPEKKLSFQWFAWDGSSYVRMNTQNWLTKQIFFRFLKST YFFKGKKQKMFLAEGKMKTKDKNRG*" /label="ywpG CDS" gene complement(3122224..3122607) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /label="ywpG gene" promotor_-10 complement(3122629..3122648) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-10" misc_feature 3122636..3122655 /Source="Nicolas_upshift_promotors" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3122640 /Source="Nicolas_upshifts" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3122649) /Source="Nicolas_upshifts" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="upshifts" promotor_-35 complement(3122663..3122670) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-35" misc_feature 3122730..3122749 /Source="Nicolas_upshift_promotors" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3122733 /Source="Nicolas_upshifts" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3122782) /Source="Nicolas_upshifts" /id="D1878" /incds=0 /nref=2 /ntot=169 /MaxReadThrough="0.85282" /MaxDrop="4.02798" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2846" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS 3122782..3123192 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25663006" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391514.1" /db_xref="EnsemblGenomes-Gn:BSU36330" /db_xref="EnsemblGenomes-Tr:CAB15650" /db_xref="InterPro:IPR025573" /db_xref="SubtiList:BG12500" /db_xref="UniProtKB/Swiss-Prot:P94588" /translation="MKTFKLVDLNVERVDKEEQSIEQFPLIDGLIINKEDGENHWLIE ALVQKEHLSFFEQLQNSQSEAKVFVTITKKSNRPAQLTAAVKNIVKLEESIQVLLYGQ MVTRKQQGTETILESLVKEGYTGTKLIEAFKQKL*" /label="ywpF CDS" gene 3122782..3123192 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /label="ywpF gene" S_feature 3123193..3123276 /Source="Nicolas_S_feature" /locus_tag="new_3741593_3741676" /HighExp="BC, LBGtran, T3.30H, Etha, T2.0H, Lbtran, M9-stat, T3.0H, dia5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1400" downshifts 3123234 /Source="Nicolas_upshifts" /id="D1879" /incds=0 /nref=214 /ntot=260 /MaxReadThrough="1.83981" /MaxDrop="6.19197" /score="18.4023831" /energy="-14" /TU="NA" /idTUdmin="U2847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3123332..3123640) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 21800427, 21906378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sortase" /protein_id="NP_391515.1" /db_xref="EnsemblGenomes-Gn:BSU36340" /db_xref="EnsemblGenomes-Tr:CAB15651" /db_xref="GOA:P94587" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG12499" /db_xref="UniProtKB/Swiss-Prot:P94587" /translation="MRRDQKMGEGNYPLAGHHLKQKNLLFGPLENIKTGAQIVITDFK KDYIYSVTSKDIISEMDADVVEETNKKEITLITCDKAVKTEGRLVVKGELVDSFGHTN *" /label="ywpE CDS" gene complement(3123332..3123640) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /label="ywpE gene" downshifts complement(3123333) /Source="Nicolas_upshifts" /id="D1880" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="0.11027" /MaxDrop="2.8132" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2849" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS 3123984..3124820 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16740923; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative two-component sensor histidine kinase" /protein_id="NP_391516.1" /db_xref="EnsemblGenomes-Gn:BSU36350" /db_xref="EnsemblGenomes-Tr:CAB15652" /db_xref="GOA:P94586" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12498" /db_xref="UniProtKB/Swiss-Prot:P94586" /translation="MKIRERFSMVDLPVLIITAAIIGHDKYKAFHAGANDILQKPYHY SEFMARIQNLIMMKHTANQATRMEMAFLQSQIKPHFLYNVLNTIISLTHLDIEKAREV TEEFTNYLRMSFDFQNTSAISSFRHELSIINSYLSIEKTRFSNRLEVLFDIDEDIDFI LPPLMIQPLVENAVLHGVSKKRGGGWIKLTAKKQSKNEYHIKVEDNGPGITPEKQIDL LSTDFDRSVGLKNINQRLKHFCGSELMISSTPDAGTSVSMLIHLAETTGSPKELKDTE RT*" /label="ywpD CDS" gene 3123984..3124820 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /label="ywpD gene" promotor_-35 3124200..3124207 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3124222..3124241 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3124225 /Source="Nicolas_upshifts" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3124819 /Source="Nicolas_upshifts" /id="D1881" /incds=0 /nref=13 /ntot=132 /MaxReadThrough="0.11837" /MaxDrop="3.37937" /score="9.16906941" /energy="-8.6" /TU="NA" /idTUdmin="U2848" /TUdmin=154 /isTUend="FALSE" /label="downshifts" CDS complement(3124867..3125259) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /function="16.1: Circulate" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12948773, 15063854, 15165739, 16897034, 22685134, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12948773, 15063854, 15165739, 16897034, 22685134, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="large conductance mechanosensitive channel protein" /protein_id="NP_391517.1" /db_xref="EnsemblGenomes-Gn:BSU36360" /db_xref="EnsemblGenomes-Tr:CAB15653" /db_xref="GOA:P94585" /db_xref="InterPro:IPR001185" /db_xref="InterPro:IPR019823" /db_xref="InterPro:IPR036019" /db_xref="SubtiList:BG12497" /db_xref="UniProtKB/Swiss-Prot:P94585" /translation="MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVG LLLGGLDFSGLSFTFGDAVVKYGSFIQTIVNFLIISFSIFIVIRTLNGLRRKKEAEEE AAEEAVDAQEELLKEIRDLLKQQAKSPE*" /label="mscL CDS" gene complement(3124867..3125259) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /label="mscL gene" downshifts complement(3124873) /Source="Nicolas_upshifts" /id="D1882" /incds=0 /nref=216 /ntot=255 /MaxReadThrough="2.23487" /MaxDrop="6.5103" /score="28.9904077" /energy="-11.4" /TU="NA" /idTUdmin="U2849" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3125332..3125757) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /EC_number="4.2.1.59" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8910376, 12682299, 15194690, 15371447, 18093984, 22580319, 23322253, 27874013; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacyl-[acyl carrier protein] dehydratase" /protein_id="NP_391518.2" /db_xref="EnsemblGenomes-Gn:BSU36370" /db_xref="EnsemblGenomes-Tr:CAB15654" /db_xref="GOA:P94584" /db_xref="InterPro:IPR010084" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12496" /db_xref="UniProtKB/Swiss-Prot:P94584" /translation="MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEF FNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQ LHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE*" /label="fabZ CDS" gene complement(3125332..3125757) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /label="fabZ gene" promotor_-10 complement(3125818..3125837) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3125834) /Source="Nicolas_upshifts" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3125836..3125920) /Source="Nicolas_S_feature" /locus_tag="new_3744236_3744320_c" /HighExp="Diami, dia5, Cold, dia15, H2O2, C30, Etha, Oxctl, Paraq, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigD, SigA" /TUlongPSig="0.999, 0.837" /label="S1401" promotor_-35 complement(3125852..3125859) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3125899 /Source="Nicolas_upshifts" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3125902..3125921 /Source="Nicolas_upshift_promotors" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3125912..3125931) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-10" upshifts complement(3125920) /Source="Nicolas_upshifts" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="upshifts" S_feature complement(3125922..3127006) /Source="Nicolas_S_feature" /locus_tag="new_3744322_3745406_c" /HighExp="Cold, C30, Lbstat, Glucon, Glu, Paraq, Pyr, H2O2, Fru, C90" /AntisenseName="rapD" /AntisenseCor="5.8390464430913601E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.837" /label="S1402" promotor_-35 complement(3125945..3125950) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-35" CDS 3125949..3127013 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391519.1" /db_xref="EnsemblGenomes-Gn:BSU36380" /db_xref="EnsemblGenomes-Tr:CAB15655" /db_xref="GOA:P94583" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11967" /db_xref="UniProtKB/Swiss-Prot:P94583" /translation="MISKFIEKRMLNMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIK KNTKLWMRYQLFQARHQLLFENQNGLDSLFDGLYGLEDKMDDELKYYLYFFSGLYEMV KTAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY LHQFGYIKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLG FLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYLHCVYESVRALFKTGNITEAKAVLQ KGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDI TEYYKKKDDFEKAAFFIMRG*" /label="rapD CDS" gene 3125949..3127013 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /label="rapD gene" S_feature 3127014..3127898 /Source="Nicolas_S_feature" /locus_tag="new_3745414_3746298" /HighExp="M9-stat, T4.0H, T2.0H, T3.30H, T2.30H, T3.0H, T1.30H, T5.0H, T1.0H, T0.30H" /AntisenseName="flhP" /AntisenseCor="-0.32116112580252298" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1403" CDS complement(3127036..3127845) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-basal body accessory protein" /protein_id="NP_391520.2" /db_xref="EnsemblGenomes-Gn:BSU36390" /db_xref="EnsemblGenomes-Tr:CAB15656" /db_xref="GOA:P39753" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10918" /db_xref="UniProtKB/Swiss-Prot:P39753" /translation="MLRSMLTASTTLNQLQQQIDTISSNLSNSNTTGYKAKDTNFSEL VRQQFDQVDEKNEEVAKARKTPPGLRLGVGAMMSSRLVSDQGSIQKTDRDLDIAFTSP YQYLQVNVNGNRQYTRDGALYVTPSAANANQLQLVTGNGYPVLDENGNTVNIDSSMKN ITINKNGTLTASDGNAVQRFNLGVVQVNNPQELKSEGNNLFSIDNAAAFEELNGANRQ NIGMQQGSLEMSNVDISEQMTDLITSQRSYQLNSRTITMGDQMLGLINSVR*" /label="flhP CDS" gene complement(3127036..3127845) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /label="flhP gene" downshifts complement(3127051) /Source="Nicolas_upshifts" /id="D1883" /incds=0 /nref=174 /ntot=256 /MaxReadThrough="4.65461" /MaxDrop="5.56507" /score="8.59904552" /energy="-7.4" /TU="U2853" /idTUdmin="U2854" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3127879..3128691) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1905667, 16621824, 22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905667, 16621824, 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body accessory rod protein" /protein_id="NP_391521.1" /db_xref="EnsemblGenomes-Gn:BSU36400" /db_xref="EnsemblGenomes-Tr:CAB15657" /db_xref="GOA:P39752" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10917" /db_xref="UniProtKB/Swiss-Prot:P39752" /translation="MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAF PEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQV PMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNE NFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAY SLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI*" /label="flhO CDS" gene complement(3127879..3128691) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /label="flhO gene" S_feature complement(3128692..3128771) /Source="Nicolas_S_feature" /locus_tag="new_3747092_3747171_c" /HighExp="C90, Lbtran, Cold, GM-0.2, GM 15, GM 10, C30, GM 90, GM-0.1, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.999, 0.837" /TUlongSig="NA" /TUlongPSig="NA" /label="S1404" promotor_-35 3128722..3128729 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3128743..3128762 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3128752 /Source="Nicolas_upshifts" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3128765..3128783) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-10" upshifts complement(3128771) /Source="Nicolas_upshifts" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="upshifts" promotor_-35 complement(3128797..3128804) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-35" CDS complement(3128854..3129855) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="MreB-like morphogen" /protein_id="NP_391522.2" /db_xref="EnsemblGenomes-Gn:BSU36410" /db_xref="EnsemblGenomes-Tr:CAB15658" /db_xref="GOA:P39751" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10916" /db_xref="UniProtKB/Swiss-Prot:P39751" /translation="MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAV GEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICC PTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTD IAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDAR HEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIID RGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS* " /label="mbl CDS" gene complement(3128854..3129855) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /label="mbl gene" downshifts complement(3128860) /Source="Nicolas_upshifts" /id="D1884" /incds=0 /nref=108 /ntot=240 /MaxReadThrough="5.6154" /MaxDrop="4.18076" /score="20.122637" /energy="-11.2" /TU="U2854" /idTUdmin="U2855" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" misc_feature complement(3129910..3129929) /Source="Nicolas_upshift_promotors" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3129934) /Source="Nicolas_upshifts" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="upshifts" S_feature complement(3129936..3130020) /Source="Nicolas_S_feature" /locus_tag="new_3748336_3748420_c" /HighExp="S5, S6, S4, S7, S8, S3, B36, T5.0H, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1405" CDS complement(3130021..3130302) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023218, 9324264, 15598884, 22720735, 24584501" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023218, 9324264, 15598884, 22720735, 24584501; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (stage III sporulation)" /protein_id="NP_391523.1" /db_xref="EnsemblGenomes-Gn:BSU36420" /db_xref="EnsemblGenomes-Tr:CAB15659" /db_xref="GOA:P15281" /db_xref="InterPro:IPR014208" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="PDB:2L0K" /db_xref="SubtiList:BG10408" /db_xref="UniProtKB/Swiss-Prot:P15281" /translation="MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTER LPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS*" /label="spoIIID CDS" gene complement(3130021..3130302) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /label="spoIIID gene" CDS complement(3130317..3130427) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9023218; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative factor required for translation of spoIIID" /protein_id="NP_391524.1" /db_xref="EnsemblGenomes-Gn:BSU36430" /db_xref="EnsemblGenomes-Tr:CAB15660" /db_xref="SubtiList:BG11984" /db_xref="UniProtKB/Swiss-Prot:O32276" /translation="MGIFHKLTFKTIQRRSGIMNDSLQNTDLISHFSHPF*" /label="usd CDS" gene complement(3130317..3130427) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /label="usd gene" promotor_-10 complement(3130458..3130476) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3130480) /Source="Nicolas_upshifts" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3130492..3130497) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3130573..3130579 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3130593..3130612 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3130609 /Source="Nicolas_upshifts" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="upshifts" CDS 3130652..3131065 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391525.1" /db_xref="EnsemblGenomes-Gn:BSU36440" /db_xref="EnsemblGenomes-Tr:CAB15661" /db_xref="GOA:P94578" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12495" /db_xref="UniProtKB/Swiss-Prot:P94578" /translation="MSYVNRHLIHQINQSARLIAKKANEQLEPFGLYSSQWSVLYCLR TIGPMTQKEIWSYLNVEAPTVTRTIKRLEENGWVQRRQGEDKREKLVVLTKEAEKKYE EINVKMLKFEEELLADFRDEDKEAFSHLFRMFLQQ*" /label="ywoH CDS" gene 3130652..3131065 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /label="ywoH gene" CDS 3131087..3132277 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391526.1" /db_xref="EnsemblGenomes-Gn:BSU36450" /db_xref="EnsemblGenomes-Tr:CAB15662" /db_xref="GOA:P94577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12494" /db_xref="UniProtKB/Swiss-Prot:P94577" /translation="MKKADAIWTKDFIMVLLVNLFVFVFFYTFLTVLPIYTLQELGGT ESQGGLLISLFLLSAIITRPFSGAIVERFGKKRMAIVSMALFALSSFLYMPIHNFSLL LGLRFFQGIWFSILTTVTGAIAADIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMR VVSFPVFFTAFALFMVAGLLVSFLIKVPQSKDSGTTVFRFAFSDMFEKGALKIATVGL FISFCYSTVTSYLSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIY PSILIFSVGLCMLSFTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATA TFFTFFDSGIAVGSYVFGLFVASAGFSAIYLTAGLFVLIALLLYTWSQKKPAEAEGKV SIAE*" /label="ywoG CDS" gene 3131087..3132277 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /label="ywoG gene" CDS complement(3132368..3133774) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15266115, 16607952, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pectin lyase" /protein_id="NP_391527.1" /db_xref="EnsemblGenomes-Gn:BSU36460" /db_xref="EnsemblGenomes-Tr:CAB15663" /db_xref="GOA:P94576" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12493" /db_xref="UniProtKB/Swiss-Prot:P94576" /translation="MRKWYFILLAGVLTSVILAFVYDKTKANEEGSGDYLYVSPNGSD QNEGTKEKPFRTLAHASEKAAAGTTVMIREGTYHETLDVKHSGTDGKPITFRNYENEN VVISGESVANAEYETPLIRIHDKHDIAISGLTIQDLSVSSEEATAIGIYVSGSSSHIA IKDNHIRGIKTTADEGNAHGIAVYGTGSMKDIRIEDNTVEKLTLGASEAVVLNGNIDG FTVAGNVVRNNNNIGIDLIGYEGTADKNDYVRNGVVENNTVYQNSTYGNPAYGDEYSA GGIYVDGGHDIEIKNNTVYDNDIGIEATSEHKGKYANAIQITDNKVYNNAYTGISIGG YDKKRGGTSNSLIARNIMYRNDTKGLYGGQLLLQYDTKNNTIEKNILTAGDSRLFIGN DFTENEGNTVNHNVYHKEADQDGIWMWKKKEYDSFSSYRKATKNDQQSIYADPMFRDE ASYDFSLDPDSPARPVIE*" /label="ywoF CDS" gene complement(3132368..3133774) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /label="ywoF gene" downshifts complement(3132665) /Source="Nicolas_upshifts" /id="D1885" /incds=1 /nref=1 /ntot=78 /MaxReadThrough="5.28695" /MaxDrop="2.1962" /score="4.73902293" /energy="-22.3" /TU="U2857" /idTUdmin="U2857" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3133807..3133826) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3133825) /Source="Nicolas_upshifts" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3133841..3133844) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3133880..3135352) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 15849754, 16850406, 26967546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 15849754, 16850406, 26967546; Product type t : transporter" /codon_start=1 /transl_table=11 /product="allantoin permease" /protein_id="NP_391528.1" /db_xref="EnsemblGenomes-Gn:BSU36470" /db_xref="EnsemblGenomes-Tr:CAB15664" /db_xref="GOA:P94575" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR012681" /db_xref="SubtiList:BG12492" /db_xref="UniProtKB/Swiss-Prot:P94575" /translation="MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNI PTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGI YGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLL SFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGK FHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFA FASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPA YDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMM ADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYD ISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE*" /label="pucI CDS" gene complement(3133880..3135352) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /label="pucI gene" CDS complement(3135533..3136891) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391529.1" /db_xref="EnsemblGenomes-Gn:BSU36480" /db_xref="EnsemblGenomes-Tr:CAB15665" /db_xref="GOA:P94574" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12491" /db_xref="UniProtKB/Swiss-Prot:P94574" /translation="MLSKKSRAVFLTAVASGTMLNPLNSSMISLALHSIQHEFHLSFT TVSWLISSFYLASAVAQPVTGKLGDLIGRKRLFLFGLILVAVSAIGAPFAPTFMTLLV MRLFQSVGSSAIYPSGVGLIRNHIHERQASALAVLSIFASAMTALGPTAGGFLIVWGG WPAIFIVNLPFIILSFLLGLYMFPKDQKKGAGIKTIIRQLDILGIVLFAGGIIFLLSF LLSFSTSPHAVEGVLGLLLLCAFVWRELKTDKPFIDVRLFKTQRNLSAVYVQFILLNV FFYCLFFGLPSYFQDEMHLSVQTSGLFMLFMSGMSIVVSPLTGKWIDRSGVVKPIFAG ALLMTAGAVLLTIFFINVQTIGKGLILSLLGIGYGLGNVALQAAMLETSPSNMVGTTS GLFQTCRYLGSILSSVILGILFGKEITAAHFDMMGIIMIIAGGASLLMAVRFAALMKT AS*" /label="ywoD CDS" gene complement(3135533..3136891) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /label="ywoD gene" downshifts complement(3135547) /Source="Nicolas_upshifts" /id="D1886" /incds=0 /nref=58 /ntot=198 /MaxReadThrough="1.44148" /MaxDrop="4.13092" /score="20.2036192" /energy="-12.8" /TU="NA" /idTUdmin="U2858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3136891..3137460) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of isochorismatase family" /protein_id="NP_391530.2" /db_xref="EnsemblGenomes-Gn:BSU36490" /db_xref="EnsemblGenomes-Tr:CAB15666" /db_xref="GOA:P94573" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12490" /db_xref="UniProtKB/Swiss-Prot:P94573" /translation="MMNTLNIDFQKTALVIIDLQKGIVPIDQSGQVVPNAKKLVDEFR KHNGFISFVNVAFHDGADALKPQTDEPAQGGSGEMPADWAEFVPEIGVQDGDYTVTKR QWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQLGYQQIFITDAMSTFS DEEHEATLRFIFPRIGKSRTTEEFLEQVK*" /label="ywoC CDS" gene complement(3136891..3137460) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /label="ywoC gene" promotor_-10 complement(3137479..3137490) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3137497) /Source="Nicolas_upshifts" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3137504..3137510) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3137567..3137734) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CCQ48605.1" /translation="MSYPALDGPPQIHGHFQAGTDRQQAGDEAMTPFMITVLAGLFVC TTCYYYIKEKS*" /label="hypothetical protein CDS" gene complement(3137567..3137734) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /pseudo /label="gene" CDS complement(3137644..3138108) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21856850; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391531.1" /db_xref="EnsemblGenomes-Gn:BSU36500" /db_xref="EnsemblGenomes-Tr:CAB15667" /db_xref="GOA:P94572" /db_xref="InterPro:IPR020218" /db_xref="SubtiList:BG12489" /db_xref="UniProtKB/Swiss-Prot:P94572" /translation="MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEV TPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIV NIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR*" /label="ywoB CDS" gene complement(3137644..3138108) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /label="ywoB gene" promotor_-10 complement(3138138..3138157) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3138143) /Source="Nicolas_upshifts" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3138171..3138178) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3138309..3138312 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3138327..3138346 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3138331 /Source="Nicolas_upshifts" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3138390..3139604 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 15849754, 16850406, 17001076, 21435182" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 15849754, 16850406, 17001076, 21435182; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ammonium transporter" /protein_id="NP_391532.1" /db_xref="EnsemblGenomes-Gn:BSU36510" /db_xref="EnsemblGenomes-Tr:CAB15668" /db_xref="GOA:Q07429" /db_xref="InterPro:IPR001905" /db_xref="InterPro:IPR018047" /db_xref="InterPro:IPR024041" /db_xref="InterPro:IPR029020" /db_xref="SubtiList:BG10869" /db_xref="UniProtKB/Swiss-Prot:Q07429" /translation="MQMGDTVFMFFCALLVWLMTPGLALFYGGMVKSKNVLSTAMHSF SSIAIVSIVWVLFGYTLAFAPGNSIIGGLEWAGLKGVGFDPGDYSDTIPHSLFMMFQM TFAVLTTAIISGAFAERMRFGAFLLFSVLWASLVYTPVAHWVWGGGWIGQLGALDFAG GNVVHISSGVAGLVLAIVLGKRKDGTASSPHNLIYTFLGGALIWFGWFGFNVGSALTL DGVAMYAFINTNTAAAAGIAGWILVEWIINKKPTMLGAVSGAIAGLVAITPAAGFVTP FASIIIGIIGGAVCFWGVFSLKKKFGYDDALDAFGLHGIGGTWGGIATGLFATTSVNS AGADGLFYGDASLIWKQIVAIAATYVFVFIVTFVIIKIVSLFLPLRATEEEESLGLDL TMHGEKAYQDSM*" /label="amtB CDS" gene 3138390..3139604 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /label="amtB gene" promotor_-10 complement(3139220..3139238) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3139221) /Source="Nicolas_upshifts" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3139252..3139259) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3139470..3139476 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3139490..3139509 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3139492 /Source="Nicolas_upshifts" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3139616..3139966 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 17001076, 21435182, 23461034, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen-regulated PII-like regulator protein" /protein_id="NP_391533.1" /db_xref="EnsemblGenomes-Gn:BSU36520" /db_xref="EnsemblGenomes-Tr:CAB15669" /db_xref="GOA:Q07428" /db_xref="InterPro:IPR002187" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017918" /db_xref="PDB:4R25" /db_xref="PDB:4RX6" /db_xref="SubtiList:BG10870" /db_xref="UniProtKB/Swiss-Prot:Q07428" /translation="MSGQMFKVEIVTRPANFEKLKQELGKIGVTSLTFSNVHGCGLQK AHTELYRGVKIESNVYERLKIEIVVSKVPVDQVTETAKRVLKTGSPGDGKIFVYEISN TINIRTGEEGPEAL*" /label="glnK CDS" gene 3139616..3139966 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /label="glnK gene" downshifts 3139959 /Source="Nicolas_upshifts" /id="D1887" /incds=0 /nref=179 /ntot=251 /MaxReadThrough="2.13701" /MaxDrop="8.63831" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2860" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3140018..3140026 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3140040..3140048 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3140047 /Source="Nicolas_upshifts" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3140089..3140098 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3140111..3140126 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3140115 /Source="Nicolas_upshifts" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" CDS 3140147..3140728 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /EC_number="3.6.1.27" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate phosphatase (bacitracin resistance)" /protein_id="NP_391534.1" /db_xref="EnsemblGenomes-Gn:BSU36530" /db_xref="EnsemblGenomes-Tr:CAB15670" /db_xref="GOA:P94571" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR033879" /db_xref="InterPro:IPR036938" /db_xref="SubtiList:BG12488" /db_xref="UniProtKB/Swiss-Prot:P94571" /translation="MNYEIFKAIHGLSHHNSVLDSIMVFITEYAIVAYALILLAIWLF GNTQSRKHVLYAGITGIAGLVINYLITLVYFEPRPFVAHTVHTLIPHAADASFPSDHT TGALAISIAMLFRNRKIGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAIIIGFLFF RFSDLLRPFVDLVVRIYEAIINKLTKKPTDQNF*" /label="bcrC CDS" gene 3140147..3140728 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /label="bcrC gene" promotor_-10 complement(3140245..3140264) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3140255) /Source="Nicolas_upshifts" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3140278..3140286) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3140709 /Source="Nicolas_upshifts" /id="D1888" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.1929" /MaxDrop="6.53316" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2863" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(3140769..3141191) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14762009, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391535.1" /db_xref="EnsemblGenomes-Gn:BSU36540" /db_xref="EnsemblGenomes-Tr:CAB15671" /db_xref="GOA:P71045" /db_xref="InterPro:IPR006976" /db_xref="SubtiList:BG12487" /db_xref="UniProtKB/Swiss-Prot:P71045" /translation="MNRLLLAGWIFFILLSVCTESFSGMVVSQTVAFHFQPHPDLSQF LVMDFTELTVPEAFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFTEVLQLF FSRNGCIRDVLIDAVGIGLFYGLYVLAKRRKQEMYEKY*" /label="ywnJ CDS" gene complement(3140769..3141191) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /label="ywnJ gene" downshifts complement(3140788) /Source="Nicolas_upshifts" /id="D1889" /incds=0 /nref=9 /ntot=75 /MaxReadThrough="0.80227" /MaxDrop="3.65224" /score="4.98901321" /energy="-13.6" /TU="NA" /idTUdmin="U2869" /TUdmin=215 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3141226..3141241) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3141245) /Source="Nicolas_upshifts" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3141254..3141263) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3141302..3142153) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /function="16.8: Protect" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore protein required for alternative engulfment" /protein_id="NP_391536.1" /db_xref="EnsemblGenomes-Gn:BSU36550" /db_xref="EnsemblGenomes-Tr:CAB15672" /db_xref="GOA:P71044" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11978" /db_xref="UniProtKB/Swiss-Prot:P71044" /translation="MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQS VSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAK EEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHA DGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLN FMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESST TEDTEQS*" /label="spoIIQ CDS" gene complement(3141302..3142153) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /label="spoIIQ gene" downshifts complement(3141311) /Source="Nicolas_upshifts" /id="D1890" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.592" /MaxDrop="5.16472" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts complement(3141553) /Source="Nicolas_upshifts" /id="D1891" /incds=1 /nref=4 /ntot=59 /MaxReadThrough="6.6416" /MaxDrop="3.0034" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" promotor_-35 3141790..3141792 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3141809..3141828 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3141810..3142156 /Source="Nicolas_S_feature" /locus_tag="new_3760210_3760556" /HighExp="LBGstat, LBGtran, Cold, Sw, dia15, C30, G180, Lbexp, LBGexp, UNK1" /AntisenseName="spoIIQ" /AntisenseCor="-0.81767802234568998" /AntisenseRegPval="-65.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1406" upshifts 3141810 /Source="Nicolas_upshifts" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3142148..3142151 /Source="Nicolas_upshift_promotors" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3142158..3142293 /Source="Nicolas_S_feature" /locus_tag="new_3760558_3760693" /HighExp="LBGstat, S8, LBGtran, Sw, LoTm, BC, Cold, S7, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.122, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1407" upshifts 3142158 /Source="Nicolas_upshifts" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3142187) /Source="Nicolas_upshifts" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3142193..3142202) /Source="Nicolas_upshift_promotors" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3142294..3142785 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /EC_number="2.3.1.183" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 16021622, 27694229; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacid analogs (phosphinothricin) N-acetyltransferase" /protein_id="NP_391537.1" /db_xref="EnsemblGenomes-Gn:BSU36560" /db_xref="EnsemblGenomes-Tr:CAB15673" /db_xref="GOA:P71043" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1VHS" /db_xref="SubtiList:BG12486" /db_xref="UniProtKB/Swiss-Prot:P71043" /translation="MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFS GHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQ EALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGR ELS*" /label="ywnH CDS" gene 3142294..3142785 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /label="ywnH gene" promotor_-35 3142523..3142528 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3142544..3142562 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3142555 /Source="Nicolas_upshifts" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3142646..3143554) /Source="Nicolas_S_feature" /locus_tag="new_3761046_3761954_c" /HighExp="H2O2, dia15, Diami, dia5, S8, Paraq, G180, G135, C30, G150" /AntisenseName="ywnG" /AntisenseCor="0.27407310266030799" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S1408" CDS 3142782..3143300 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391538.1" /db_xref="EnsemblGenomes-Gn:BSU36570" /db_xref="EnsemblGenomes-Tr:CAB15674" /db_xref="GOA:P71042" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12485" /db_xref="UniProtKB/Swiss-Prot:P71042" /translation="MISLDKDENEIEHHNEENSLVEQETAPVGQESRQLSASAVKSLS DIAKWGKISGILLIIMGSLVTLSVLMTVIGAIPGVLLIISGVFLMRSAKAAAEAEGNL TGSAGESMLENYGTFIKMQLFYAASSIVTVLIGIIVAIFVLVVIGIAAFENTPSYDDP DSYYYEDDPVFE*" /label="ywnG CDS" gene 3142782..3143300 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /label="ywnG gene" downshifts 3143105 /Source="Nicolas_upshifts" /id="D1892" /incds=1 /nref=1 /ntot=29 /MaxReadThrough="4.194" /MaxDrop="1.82458" /score="-3.39058903" /energy="-13.3" /TU="U2867,U2868,U2870" /idTUdmin="U2868" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 3143303 /Source="Nicolas_upshifts" /id="D1893" /incds=0 /nref=3 /ntot=133 /MaxReadThrough="2.87136" /MaxDrop="2.9486" /score="-3.39058903" /energy="-13.3" /TU="U2867" /idTUdmin="U2870" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3143459..3143590 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514007.1" /translation="MNIKKTDEVGINPKPHFLFRVSACKKTHPDRLENLNNPGADLL* " /label="hypothetical protein CDS" gene 3143459..3143590 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /label="gene" CDS complement(3143587..3144021) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391539.1" /db_xref="EnsemblGenomes-Gn:BSU36580" /db_xref="EnsemblGenomes-Tr:CAB15675" /db_xref="GOA:P71041" /db_xref="InterPro:IPR020205" /db_xref="SubtiList:BG12484" /db_xref="UniProtKB/Swiss-Prot:P71041" /translation="MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAF SLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRI KKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY*" /label="ywnF CDS" gene complement(3143587..3144021) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /label="ywnF gene" downshifts complement(3143599) /Source="Nicolas_upshifts" /id="D1894" /incds=0 /nref=174 /ntot=254 /MaxReadThrough="4.22489" /MaxDrop="5.35802" /score="21.5198482" /energy="-21.3" /TU="U2871" /idTUdmin="U2873" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3144070..3144089) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3144077) /Source="Nicolas_upshifts" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3144079..3144376) /Source="Nicolas_S_feature" /locus_tag="new_3762479_3762776_c" /HighExp="Etha, S6, S3, S4, S8, S5, S7, M9-stat, Sw, Salt" /AntisenseName="clsA" /AntisenseCor="-0.16109419145114601" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF" /TUshortPSig="0.99, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1409" promotor_-35 complement(3144104..3144111) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3144150..3144154 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3144171..3144190 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3144183..3144263 /Source="Nicolas_S_feature" /locus_tag="new_3762583_3762663" /HighExp="LBGstat, Diami, dia15, G180, Oxctl, H2O2, T0.30H, S8, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1410" upshifts 3144184 /Source="Nicolas_upshifts" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3144264..3145712 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14973018, 16755131, 18820022, 26708983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16755131, 18820022, 26708983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cardiolipin synthase (major)" /protein_id="NP_391540.1" /db_xref="EnsemblGenomes-Gn:BSU36590" /db_xref="EnsemblGenomes-Tr:CAB15676" /db_xref="GOA:P71040" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG12483" /db_xref="UniProtKB/Swiss-Prot:P71040" /translation="MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIP VLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKD LIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKK LRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLN YRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILD WNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSIL IQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVY IYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDL LVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL*" /label="clsA CDS" gene 3144264..3145712 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /label="clsA gene" upshifts complement(3144376) /Source="Nicolas_upshifts" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3144377..3144395) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3144378..3144721) /Source="Nicolas_S_feature" /locus_tag="new_3762778_3763121_c" /HighExp="S6, S8, S4, S5, S7, S3, T5.0H, M9-stat, C30, T4.0H" /AntisenseName="clsA" /AntisenseCor="3.3648966966722899E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1411" promotor_-35 complement(3144411..3144417) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3144699..3144717) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3144721) /Source="Nicolas_upshifts" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3144733..3144738) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3145701 /Source="Nicolas_upshifts" /id="D1895" /incds=0 /nref=6 /ntot=214 /MaxReadThrough="0.7051" /MaxDrop="4.44298" /score="26.7449315" /energy="-19.5" /TU="NA" /idTUdmin="U2872" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3145733..3146506) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10200972, 11581256, 18502870" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 11581256, 18502870; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulating efflux transporters synthesis (Fur-independent bacillibactin export)" /protein_id="NP_391541.1" /db_xref="EnsemblGenomes-Gn:BSU36600" /db_xref="EnsemblGenomes-Tr:CAB15677" /db_xref="GOA:P71039" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012925" /db_xref="InterPro:IPR036244" /db_xref="PDB:1JBG" /db_xref="PDB:1R8D" /db_xref="SubtiList:BG12482" /db_xref="UniProtKB/Swiss-Prot:P71039" /translation="MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDA DLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTID RTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGE VYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP*" /label="mta CDS" gene complement(3145733..3146506) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /label="mta gene" downshifts complement(3145755) /Source="Nicolas_upshifts" /id="D1896" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="0.46006" /MaxDrop="2.97389" /score="11.4339746" /energy="-19.5" /TU="NA" /idTUdmin="U2876" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" promotor_-35 3146581..3146584 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3146600..3146619 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3146604 /Source="Nicolas_upshifts" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="upshifts" CDS 3146651..3147034 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391542.1" /db_xref="EnsemblGenomes-Gn:BSU36610" /db_xref="EnsemblGenomes-Tr:CAB15678" /db_xref="GOA:P71038" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12481" /db_xref="UniProtKB/Swiss-Prot:P71038" /translation="MNPETMNKTLISISKWGKATGILFIIMGAITALSGAFFFLIGAV PGVLQIISGIFLMRSAREAGQMAEHNSGQSEDLMLENYAKFVKMQGIYLIVSIAVSIL AIIAFFIFLMLGIADGLFSDTYSTY*" /label="ywnC CDS" gene 3146651..3147034 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /label="ywnC gene" downshifts 3147021 /Source="Nicolas_upshifts" /id="D1897" /incds=0 /nref=60 /ntot=180 /MaxReadThrough="1.0319" /MaxDrop="4.45212" /score="35.5991488" /energy="-11.4" /TU="NA" /idTUdmin="U2875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3147069..3147710) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391543.1" /db_xref="EnsemblGenomes-Gn:BSU36620" /db_xref="EnsemblGenomes-Tr:CAB15679" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12480" /db_xref="UniProtKB/Swiss-Prot:P71037" /translation="MKIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAI LEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLHVEAGRALISILKDAKHTRLLVVGGA GSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSPAAFFDPAG KRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE*" /label="ywnB CDS" gene complement(3147069..3147710) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /label="ywnB gene" downshifts complement(3147119) /Source="Nicolas_upshifts" /id="D1898" /incds=0 /nref=20 /ntot=170 /MaxReadThrough="3.62026" /MaxDrop="4.98934" /score="21.1363072" /energy="-11.4" /TU="U2876" /idTUdmin="U2876" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(3147778..3148179) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391544.1" /db_xref="EnsemblGenomes-Gn:BSU36630" /db_xref="EnsemblGenomes-Tr:CAB15680" /db_xref="GOA:P71036" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1XD7" /db_xref="SubtiList:BG12479" /db_xref="UniProtKB/Swiss-Prot:P71036" /translation="MINSRLAVAIHILSLISMDEKTSSEIIADSVNTNPVVVRRMISL LKKADILTSRAGVPGASLKKDPADISLLEVYRAVQKQEELFAVHENPNPKCPVGKKIQ NALDETFESVQRAMENELASKSLKDVMNHLF*" /label="ywnA CDS" gene complement(3147778..3148179) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /label="ywnA gene" promotor_-10 complement(3148228..3148247) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3148238) /Source="Nicolas_upshifts" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3148240..3148313) /Source="Nicolas_S_feature" /locus_tag="new_3766640_3766713_c" /HighExp="BT, Etha, S1, B60, LoTm, B36, S2, Glucon, Sw, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.18507799999999999" /TUshortSig="Sig-" /TUshortPSig="0.106" /TUlongSig="SigH, SigA, SigB, SigB" /TUlongPSig="1, 0.993, 1, 0.995" /label="S1412" promotor_-35 complement(3148262..3148267) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3148314..3150023) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (alpha subunit)" /protein_id="NP_391545.1" /db_xref="EnsemblGenomes-Gn:BSU36640" /db_xref="EnsemblGenomes-Tr:CAB15681" /db_xref="GOA:P77837" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11983" /db_xref="UniProtKB/Swiss-Prot:P77837" /translation="MKMSREEYAELFGPTTGDKIRLGDTDLWIEVEKDFTVYGEEMIF GGGKTIRDGMGQNGRITGKDGALDLVITNVVLLDYTGIVKADVGVKDGRIVGVGKSGN PDIMDGVDPHMVIGAGTEVISGEGKILTAGGVDTHIHFICPQQMEVALSSGVTTLLGG GTGPATGSKATTCTSGAWYMARMLEAAEEFPINVGFLGKGNASDKAPLIEQVEAGAIG LKLHEDWGTTPSAIKTCMEVVDEADIQVAIHTDTINEAGFLENTLDAIGDRVIHTYHI EGAGGGHAPDIMKLASYANILPSSTTPTIPYTVNTMDEHLDMMMVCHHLDAKVPEDVA FSHSRIRAATIAAEDILHDIGAISMTSSDSQAMGRVGEVIIRTWQVADKMKKQRGALA GENGNDNVRAKRYIAKYTINPAITHGLSHEVGSVEKGKLADLVLWDPVFFGVKPELVL KGGMIARAQMGDPNASIPTPEPVFMRQMYASYGKANRSTSITFMSQASIERGVAESLG LEKRISPVKNIRKLSKLDMKLNSALPKIEIDPKTYQVFADGEELSCQPVDYVPLGQRY FLF*" /label="ureC CDS" gene complement(3148314..3150023) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /label="ureC gene" CDS complement(3150020..3150394) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (beta subunit)" /protein_id="NP_391546.1" /db_xref="EnsemblGenomes-Gn:BSU36650" /db_xref="EnsemblGenomes-Tr:CAB15682" /db_xref="GOA:P71035" /db_xref="InterPro:IPR002019" /db_xref="InterPro:IPR036461" /db_xref="SubtiList:BG11982" /db_xref="UniProtKB/Swiss-Prot:P71035" /translation="MKPGAFQIAEGTITINEGREIREVTVKNTGSRSIQVGSHFHFAE ANGALLFDRELAIGMRLDVPSGTSVRFEPGEQKTVSLVEIRGRKTIRGLNGMADTFID ERGKEKTLANLKQAGWMEGVIR*" /label="ureB CDS" gene complement(3150020..3150394) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /label="ureB gene" CDS complement(3150391..3150708) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /EC_number="3.5.1.5" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (gamma subunit)" /protein_id="NP_391547.1" /db_xref="EnsemblGenomes-Gn:BSU36660" /db_xref="EnsemblGenomes-Tr:CAB15683" /db_xref="GOA:P75030" /db_xref="InterPro:IPR002026" /db_xref="InterPro:IPR012010" /db_xref="InterPro:IPR036463" /db_xref="SubtiList:BG11981" /db_xref="UniProtKB/Swiss-Prot:P75030" /translation="MKLTPVEQEKLLIFAAGELAKQRKARGVLLNYPEAAAYITCFIM EGARDGKGVAELMEAGRHVLTEKDVMEGVPEMLDSIQVEATFPDGVKLVTVHQPISAE VKS*" /label="ureA CDS" gene complement(3150391..3150708) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /label="ureA gene" S_feature complement(3150709..3150793) /Source="Nicolas_S_feature" /locus_tag="new_3769109_3769193_c" /HighExp="BT, B60, B36, S1, Etha, LoTm, M9-stat, S2, T0.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigH, SigB" /TUshortPSig="0.106, 1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1413" upshifts complement(3150793) /Source="Nicolas_upshifts" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3150795..3150808) /Source="Nicolas_upshift_promotors" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(3150795..3150888) /Source="Nicolas_S_feature" /locus_tag="new_3769195_3769288_c" /HighExp="BT, Etha, B60, S1, B36, BC, S2, LoTm, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30781199999999997" /TUshortSig="SigH, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1414" CDS complement(3150889..3151053) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (putative phage interference protein)" /protein_id="YP_009514008.1" /translation="MVNLKNILLNKQLEGIQILIVELVRQVIIEISRKKDICYLSRAQ SGKRVNLIFP*" /label="ywzE CDS" gene complement(3150889..3151053) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /label="ywzE gene" promotor_-10 complement(3150976..3150994) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-10" upshifts complement(3150988) /Source="Nicolas_upshifts" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="upshifts" promotor_-35 complement(3151006..3151014) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-35" S_feature complement(3151054..3151225) /Source="Nicolas_S_feature" /locus_tag="new_3769454_3769625_c" /HighExp="Etha, BT, S1, GM-0.2, GM-0.1, Salt, GM 5, T-5.40H, MG 60, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1415" CDS complement(3151226..3151408) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="PSEUDO:CAX52705.1" /translation="MKAGILHSLRGTVAISEVTVHDAELMAIVGFSVSWRSAPQTGLH AMLPVAEQNNGLPSGM*" /label="ywzF CDS" gene complement(3151226..3151408) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /pseudo /label="ywzF gene" S_feature complement(3151409..3151555) /Source="Nicolas_S_feature" /locus_tag="new_3769809_3769955_c" /HighExp="Etha, BT, S1, Salt, GM-0.2, GM-0.1, M9-stat, GM 5, GM 45, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15897800000000001" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1416" promotor_-10 complement(3151543..3151562) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3151555) /Source="Nicolas_upshifts" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" S_feature complement(3151557..3151671) /Source="Nicolas_S_feature" /locus_tag="new_3769957_3770070_c" /HighExp="Etha, Salt, M9-stat, S8, B60, B36, Sw, Gly, LoTm, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1417" promotor_-35 complement(3151577..3151584) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" Polymorphism join(3151658,3151660) /Source="geneious" /ID="SNP_BsDelta6_3770059_3770058" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)8 -> (A)9" /Codon_Change /Coverage=64 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="2.1e-197" /Variant_Raw_Frequency=61 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 3151685 /Source="Nicolas_upshifts" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3151688..3151692 /Source="Nicolas_upshift_promotors" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3151705..3151893) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10376822, 11988534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376822, 11988534; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein" /protein_id="NP_391548.1" /db_xref="EnsemblGenomes-Gn:BSU36670" /db_xref="EnsemblGenomes-Tr:CAB15684" /db_xref="InterPro:IPR008462" /db_xref="InterPro:IPR036629" /db_xref="SubtiList:BG12478" /db_xref="UniProtKB/Swiss-Prot:P70964" /translation="MGNDSVKDKMKGGFNKAKGEVKDKVGDMADRTDMQAEGKKDKAK GEIQKDIGKAKDKFSDKD*" /label="csbD CDS" gene complement(3151705..3151893) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /label="csbD gene" downshifts complement(3151716) /Source="Nicolas_upshifts" /id="D1899" /incds=0 /nref=69 /ntot=139 /MaxReadThrough="6.39376" /MaxDrop="6.75256" /score="21.8463823" /energy="-10.2" /TU="U2881" /idTUdmin="U2882" /TUdmin=221 /isTUend="FALSE" /label="downshifts" downshifts 3151883 /Source="Nicolas_upshifts" /id="D1900" /incds=0 /nref=15 /ntot=36 /MaxReadThrough="0.59322" /MaxDrop="5.27268" /score="-5.47050177" /energy="-8.1" /TU="NA" /idTUdmin="U2880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3151919..3151937) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3151930) /Source="Nicolas_upshifts" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3151951..3151957) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3151966..3152466) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391549.2" /db_xref="EnsemblGenomes-Gn:BSU36680" /db_xref="EnsemblGenomes-Tr:CAB15685" /db_xref="GOA:P70963" /db_xref="SubtiList:BG12477" /db_xref="UniProtKB/Swiss-Prot:P70963" /translation="MHVRGNSMFGFNDMVKFLWSFLIVLPLVQIIHVSGHSFMAFIFG GKGSLDIGMGKTLLKIGPIRFRTIYFIDSFCRYGELKIDNRFSNALVYAGGCLFNLIT IFAINLLIIHSVLKPNVFFYQFVYFSTYYVFFALLPVRYSEKKSSDGLAIYKVLRYGE RYEIDK*" /label="ywmF CDS" gene complement(3151966..3152466) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /label="ywmF gene" promotor_-10 complement(3152502..3152521) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3152509) /Source="Nicolas_upshifts" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3152535..3152541) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3152601..3153734) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9843420, 10629174, 12875849, 19332814, 19684115" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9843420, 10629174, 12875849, 19332814, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391550.1" /db_xref="EnsemblGenomes-Gn:BSU36690" /db_xref="EnsemblGenomes-Tr:CAB15686" /db_xref="GOA:P70962" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11965" /db_xref="UniProtKB/Swiss-Prot:P70962" /translation="MAAYEIPSSQVGVKINKWYKHILAFQVADAVKLKEEIDLDIEQM EEDQLLLLYYQLISYRHQIMLDYVKPDLHEESQLQYRELIKTLESNQDSISGLSEYYF HLFRGMYEFEQNNYISAISFYRKAEKMLAFVEDEIERAEFHFKVAEVFYIMKQTHFSM NHAVQALETYKAHDFYRVRRIQCHFVISGNYIDYRNYEKALEHLDDAYRLALLEGQPR LIGSALYNIGNCYDDKGELDQAAEYFEKALPVFEDYQLEQLPKALFSLTRVLFKKQDS EAAIRYYEKGIAIAQKRNDFFSLAKYKFLQALYVESVNLNMIQEVFDYMEEKGLYVYI EEFALDAASYFSHREQYKEAVYFYEKAVSMREMIQRNDCLYEV*" /label="rapB CDS" gene complement(3152601..3153734) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /label="rapB gene" downshifts complement(3152619) /Source="Nicolas_upshifts" /id="D1901" /incds=0 /nref=244 /ntot=265 /MaxReadThrough="2.8683" /MaxDrop="6.81344" /score="30.5146793" /energy="-8.1" /TU="NA" /idTUdmin="U2883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(3153761..3153780) /Source="Nicolas_upshift_promotors" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3153768) /Source="Nicolas_upshifts" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3153831..3153849) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3153847) /Source="Nicolas_upshifts" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3153863..3153870) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3153926..3154951) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /EC_number="4.1.99.22" /function="16.10: Respire" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170340, 7860592, 16632608, 19566093, 23286307, 25896388, 25941396, 26575208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP 3',8-cyclase" /protein_id="NP_391551.1" /db_xref="EnsemblGenomes-Gn:BSU36700" /db_xref="EnsemblGenomes-Tr:CAB15687" /db_xref="GOA:P39757" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="InterPro:IPR013483" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG10980" /db_xref="UniProtKB/Swiss-Prot:P39757" /translation="MITESRQMLDKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDY PFLKKEELLSFEELERLATLFVTRFGVEKIRLTGGEPLMRKDMPELIKKLARIPGIRD IAMTTNGSLLPVYAKRLKEAGLKRVTISLDSLEDERFKKINGRGVSVSKVLEGIEAAK QAGLGVKINMVVQKGVNEKDILPMARYFKEKGHILRFIEFMDVGNTNQWEKKDVMTKA EIIDLINKHMPVEPIAPNYIGEVASRFRYLDGSGEIGVISSVSDAFCGSCNRARLSAR GELFTCLFASSGFDLRAPVRQELSDDELSEMIGTVWKNRIDQYSVDRTLSKASGKKKV EMSYIGG*" /label="moaA CDS" gene complement(3153926..3154951) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /label="moaA gene" downshifts complement(3153939) /Source="Nicolas_upshifts" /id="D1902" /incds=0 /nref=23 /ntot=147 /MaxReadThrough="3.05546" /MaxDrop="3.66108" /score="13.625744" /energy="-10.8" /TU="NA" /idTUdmin="U2885" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3154967..3155755) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /function="16.11: Scavenge (Catabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2170340, 7860592, 19114526, 20011599, 22194618; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein sulfur transferase involved in molybdenum cofactor synthesis" /protein_id="NP_391552.1" /db_xref="EnsemblGenomes-Gn:BSU36710" /db_xref="EnsemblGenomes-Tr:CAB15688" /db_xref="GOA:P39756" /db_xref="InterPro:IPR003786" /db_xref="InterPro:IPR016193" /db_xref="SubtiList:BG10979" /db_xref="UniProtKB/Swiss-Prot:P39756" /translation="MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTL VCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRV IGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAA LCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGV SIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE*" /label="fdhD CDS" gene complement(3154967..3155755) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /label="fdhD gene" promotor_-10 complement(3155781..3155800) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3155787) /Source="Nicolas_upshifts" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3155789..3156000) /Source="Nicolas_S_feature" /locus_tag="new_3774188_3774399_c" /HighExp="Etha, Sw, Salt, Heat, S8, Gly, S6, S7, BC, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16930300000000001" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1418" promotor_-35 complement(3155814..3155821) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3156001..3156162) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391553.1" /db_xref="EnsemblGenomes-Gn:BSU36720" /db_xref="EnsemblGenomes-Tr:CAB15689" /db_xref="GOA:P70966" /db_xref="SubtiList:BG12476" /db_xref="UniProtKB/Swiss-Prot:P70966" /translation="MKLFGMIFLIATVAFILLGVLLKLAAFFFVSILTLIAAIVLFTV LKKNQHNQT*" /label="ywmE CDS" gene complement(3156001..3156162) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /label="ywmE gene" promotor_-10 complement(3156175..3156193) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-10" upshifts complement(3156195) /Source="Nicolas_upshifts" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="upshifts" promotor_-35 complement(3156207..3156213) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-35" CDS complement(3156256..3156930) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391554.1" /db_xref="EnsemblGenomes-Gn:BSU36730" /db_xref="EnsemblGenomes-Tr:CAB15690" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12475" /db_xref="UniProtKB/Swiss-Prot:P70961" /translation="MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQ KTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLH PYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDP AAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKE AQKFTE*" /label="ywmD CDS" gene complement(3156256..3156930) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /label="ywmD gene" downshifts complement(3156271) /Source="Nicolas_upshifts" /id="D1903" /incds=0 /nref=16 /ntot=88 /MaxReadThrough="0.76221" /MaxDrop="4.19611" /score="25.2461653" /energy="-9.6" /TU="NA" /idTUdmin="U2886" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(3156983..3157123) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514009.1" /translation="MITQAVYAFWAEMAKNERHFKRFWTDRESSTKGSMSYIFLHFRI LA*" /label="hypothetical protein CDS" gene complement(3156983..3157123) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /label="gene" CDS complement(3157254..3157937) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391555.1" /db_xref="EnsemblGenomes-Gn:BSU36740" /db_xref="EnsemblGenomes-Tr:CAB15691" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12474" /db_xref="UniProtKB/Swiss-Prot:P70960" /translation="MKKRFSLIMMTGLLFGLTSPAFAAEKTETEAKAPANVAVLLDAS GSMAKRIDGVSKFNSAKKEISKFASSLPEGTQVKMSVFGSEGNNKNSGKVQSCEAIRN VYGFQSFNEQSFLNSLNTIGPTGWTPIAKALNEAKSSFDQLDAKGEKVVYLLTDGEET CGGNPIKTAKELQKDNITVNVIGFDYKEGYKGQLNAIAKVGGGEYFPAYTQKDVEKIF TQQSLMLSK*" /label="ywmC CDS" gene complement(3157254..3157937) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /label="ywmC gene" promotor_-35 3158314..3158318 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3158323..3159354) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15752199, 16959571, 17376078, 27226615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15752199, 16959571, 17376078, 27226615; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="lytic transglycosylase; autolysin required for complete dissolution of the asymmetric septum (stage II sporulation)" /protein_id="NP_391556.1" /db_xref="EnsemblGenomes-Gn:BSU36750" /db_xref="EnsemblGenomes-Tr:CAB15692" /db_xref="GOA:P07372" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="InterPro:IPR014225" /db_xref="SubtiList:BG10766" /db_xref="UniProtKB/Swiss-Prot:P07372" /translation="MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVS TKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQA LAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDA VASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKA TKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNS ADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADA FLNKYMAKK*" /label="spoIID CDS" gene complement(3158323..3159354) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /label="spoIID gene" promotor_-10 3158333..3158352 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3158339) /Source="Nicolas_upshifts" /id="D1904" /incds=0 /nref=56 /ntot=156 /MaxReadThrough="0.87893" /MaxDrop="6.31542" /score="12.1351765" /energy="-8.7" /TU="NA" /idTUdmin="U2888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3158351 /Source="Nicolas_upshifts" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3159382..3159400) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3159395) /Source="Nicolas_upshifts" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3159397..3159514) /Source="Nicolas_S_feature" /locus_tag="new_3777796_3777913_c" /HighExp="S8, M40t90, M9-stat, B36, LBGtran, G180, H2O2, M0t90, BT, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigI, SigWXY, SigA" /TUshortPSig="0.947, 0.999, 1, 0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1419" promotor_-35 complement(3159416..3159421) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3159456..3159461 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3159473..3162133 /Source="Nicolas_S_feature" /locus_tag="new_3777872_3780532" /HighExp="S8, S6, S7, S4, S3, C30, S5, T5.0H, T3.30H, BT" /AntisenseName="murAA" /AntisenseCor="5.8371061376981899E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.971" /TUlongSig="NA" /TUlongPSig="NA" /label="S1420" upshifts 3159473 /Source="Nicolas_upshifts" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3159477..3159495 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3159550..3160860) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /EC_number="2.5.1.7" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 14763982, 17714441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14763982, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391557.1" /db_xref="EnsemblGenomes-Gn:BSU36760" /db_xref="EnsemblGenomes-Tr:CAB15693" /db_xref="GOA:P70965" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG11955" /db_xref="UniProtKB/Swiss-Prot:P70965" /translation="MEKIIVRGGQKLNGTVKVEGAKNAVLPVIAASLLASEEKSVICD VPTLSDVYTINEVLRHLGADVHFENNEVTVNASYALQTEAPFEYVRKMRASVLVMGPL LARTGHARVALPGGCAIGSRPIDQHLKGFEAMGAEIKVGNGFIEAEVKGRLQGAKIYL DFPSVGATENLIMAAALAEGTTTLENVAKEPEIVDLANYINGMGGKIRGAGTGTIKIE GVEKLHGVKHHIIPDRIEAGTFMVAAAITEGNVLVKGAVPEHLTSLIAKMEEMGVTIK DEGEGLRVIGPKELKPIDIKTMPHPGFPTDMQSQMMALLLRASGTSMITETVFENRFM HAEEFRRMNGDIKIEGRSVIINGPVQLQGAEVAATDLRAGAALILAGLVAEGHTRVTE LKHLDRGYVDFHQKLAALGADIERVNDESASEQENKEVVSDLNA*" /label="murAA CDS" gene complement(3159550..3160860) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /label="murAA gene" downshifts complement(3159559) /Source="Nicolas_upshifts" /id="D1905" /incds=0 /nref=171 /ntot=256 /MaxReadThrough="5.3301" /MaxDrop="5.5423" /score="31.3825723" /energy="-11.8" /TU="U2890,U2891,U2892,U2894" /idTUdmin="U2890" /TUdmin="-98" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3160884..3160903) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3160891) /Source="Nicolas_upshifts" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3160894..3161634) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391558.1" /db_xref="EnsemblGenomes-Gn:BSU36770" /db_xref="EnsemblGenomes-Tr:CAB15694" /db_xref="InterPro:IPR014794" /db_xref="InterPro:IPR036209" /db_xref="PDB:2FPN" /db_xref="SubtiList:BG12473" /db_xref="UniProtKB/Swiss-Prot:O32277" /translation="MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQ DVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKN RTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTC LNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKM NLQIALRSAGMGGKHTVTVGTPIVTTEY*" /label="ywmB CDS" gene complement(3160894..3161634) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /label="ywmB gene" promotor_-35 complement(3160917..3160926) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3161265) /Source="Nicolas_upshifts" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3161267..3161275) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3161289..3161297) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3161389..3161404) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3161397) /Source="Nicolas_upshifts" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3161417..3161426) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3161635..3161762) /Source="Nicolas_S_feature" /locus_tag="new_3780034_3780161_c" /HighExp="UNK1, S2, Lbexp, MG 60, MG 15, M9-tran, M/G, G135, MG 5, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1421" CDS complement(3161763..3161993) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391559.1" /db_xref="EnsemblGenomes-Gn:BSU36780" /db_xref="EnsemblGenomes-Tr:CAB15695" /db_xref="GOA:O32278" /db_xref="InterPro:IPR009526" /db_xref="SubtiList:BG14163" /db_xref="UniProtKB/Swiss-Prot:O32278" /translation="MSVLGQQAAIGIVVHLIFIAVTWWALQAVNIDPLIKKGKVVQAR LLMILLTIAIGTAVANFFLDYLNYSQQLPYLF*" /label="ywzB CDS" gene complement(3161763..3161993) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /label="ywzB gene" S_feature complement(3161994..3162256) /Source="Nicolas_S_feature" /locus_tag="new_3780393_3780655_c" /HighExp="UNK1, S2, Lbexp, MG 5, M9-tran, M/G, MG 15, MG 60, GM 15, MG t5" /AntisenseName="ywmA" /AntisenseCor="-0.24099136307237601" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1422" misc_feature 3162129..3162148 /Source="Nicolas_upshift_promotors" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3162135 /Source="Nicolas_upshifts" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="upshifts" CDS 3162163..3162636 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391560.1" /db_xref="EnsemblGenomes-Gn:BSU36790" /db_xref="EnsemblGenomes-Tr:CAB15696" /db_xref="SubtiList:BG12472" /db_xref="UniProtKB/Swiss-Prot:P70958" /translation="MNHSFFQPEKQYGEDLPIFDQEWEAIAFYYDYRQSQIEELNELC QFFNISLTYTRESLEELENLYFQSIQELLLADWNLPIEEFEKMISVYLIDCVIARHED AEWVVKPYPYKDGAYTLGFRRHRKSWHTMNACDGLYLRPKEDRPLLSLFDSLVRS*" /label="ywmA CDS" gene 3162163..3162636 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /label="ywmA gene" promotor_-10 complement(3162240..3162259) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-10" upshifts complement(3162256) /Source="Nicolas_upshifts" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="upshifts" S_feature complement(3162258..3162641) /Source="Nicolas_S_feature" /locus_tag="new_3780657_3781040_c" /HighExp="G135, G180, G150, H2O2, Oxctl, Paraq, Cold, M9-stat, C30, S0" /AntisenseName="ywmA" /AntisenseCor="-1.9581968147303098E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1423" promotor_-35 complement(3162274..3162277) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-35" CDS complement(3162670..3163068) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /EC_number="3.6.3.14" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8021203, 12837747, 15347741, 22720735, 23967352" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 12837747, 15347741, 22720735, 23967352; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit epsilon, F1 subunit)" /protein_id="NP_391561.1" /db_xref="EnsemblGenomes-Gn:BSU36800" /db_xref="EnsemblGenomes-Tr:CAB15697" /db_xref="GOA:P37812" /db_xref="InterPro:IPR001469" /db_xref="InterPro:IPR020546" /db_xref="InterPro:IPR020547" /db_xref="InterPro:IPR036771" /db_xref="InterPro:IPR036794" /db_xref="SubtiList:BG10822" /db_xref="UniProtKB/Swiss-Prot:P37812" /translation="MKTVKVNIVTPDGPVYDADIEMVSVRAESGDLGILPGHIPTVAP LKIGAVRLKKDGQTEMVAVSGGFVEVRPDHVTILAQAAETAEGIDKERAEAARQRAQE RLNSQSDDTDIRRAELALQRALNRLDVAGK*" /label="atpC CDS" gene complement(3162670..3163068) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /label="atpC gene" downshifts complement(3162686) /Source="Nicolas_upshifts" /id="D1906" /incds=0 /nref=283 /ntot=320 /MaxReadThrough="4.15968" /MaxDrop="7.84101" /score="22.7623678" /energy="-10.8" /TU="U2897,U2899" /idTUdmin="U2895" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3163060..3163078) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3163069) /Source="Nicolas_upshifts" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3163092..3163098) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3163092..3164513) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit beta, component F1)" /protein_id="NP_391562.1" /db_xref="EnsemblGenomes-Gn:BSU36810" /db_xref="EnsemblGenomes-Tr:CAB15698" /db_xref="GOA:P37809" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10821" /db_xref="UniProtKB/Swiss-Prot:P37809" /translation="MKKGRVSQVLGPVVDVRFEDGHLPEIYNAIKISQPAASENEVGI DLTLEVALHLGDDTVRTIAMASTDGVQRGMEAVDTGAPISVPVGDVTLGRVFNVLGEN IDLNEPVPADAKKDPIHRQAPSFDQLSTEVEILETGIKVVDLLAPYIKGGKIGLFGGA GVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLFYEMSDSGVINKTAMVFGQM NEPPGARMRVALTGLTMAEHFRDVQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVG YQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERK LTEMGIYPAVDPLASTSRALAPEIVGEEHYAVAREVQSTLQRYKELQDIIAILGMDEL GEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVQGFKEILAGKYDHLPE DAFRLVGRIEEVVEKAKEMGVEV*" /label="atpD CDS" gene complement(3163092..3164513) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /label="atpD gene" CDS complement(3164539..3165402) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit gamma, component F1)" /protein_id="NP_391563.1" /db_xref="EnsemblGenomes-Gn:BSU36820" /db_xref="EnsemblGenomes-Tr:CAB15699" /db_xref="GOA:P37810" /db_xref="InterPro:IPR000131" /db_xref="InterPro:IPR023632" /db_xref="InterPro:IPR035968" /db_xref="SubtiList:BG10820" /db_xref="UniProtKB/Swiss-Prot:P37810" /translation="MASLRDIKSRITSTKKTSQITKAMQMVSAAKLNRAENNAKSFVP YMDKIQEVVSNVGRVSGNVKHPMLLSREVKKTAYLVITSDRGLAGAFNSSVLRSAYQA MQERHQSKDEYAVIAIGRVGRDFFKKREIPIISELTGLGDEVTFTEIKDLARQTIQMF IDGAFDELHLVYNHFVSAITQEVTEKKLLPLSDLGSGGGKRTASYEFEPSEEEVLEVL LPQYAESLIFGALLDSKASEHAARMTAMKNATDNAKELIDSLSLSYNRARQAAITQEI TEIVGGAAALE*" /label="atpG CDS" gene complement(3164539..3165402) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /label="atpG gene" S_feature complement(3165403..3165478) /Source="Nicolas_S_feature" /locus_tag="new_3783802_3783877_c" /HighExp="S0, S2, MG-0.2, MG-0.1, Mal, G150, BI, M0t45, G180, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1424" CDS complement(3165479..3166987) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit alpha, component F1)" /protein_id="NP_391564.1" /db_xref="EnsemblGenomes-Gn:BSU36830" /db_xref="EnsemblGenomes-Tr:CAB15700" /db_xref="GOA:P37808" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005294" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033732" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10819" /db_xref="UniProtKB/Swiss-Prot:P37808" /translation="MSIKAEEISTLIKQQIQNYQSDIEVQDVGTVIQVGDGIARVHGL DNCMAGELVEFSNGVLGMAQNLEESNVGIVILGPFSEIREGDEVKRTGRIMEVPVGEE LIGRIVNPLGQPVDGLGPILTSKTRPIESPAPGVMDRKSVHEPLQTGIKAIDALIPIG RGQRELIIGDRQTGKTSVAIDAILNQKDQDMICVYVAIGQKESTVRGVVETLRKHGAL DYTIVVTASASQPAPLLYLAPYAGVTMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLL LRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGAGSITALPFVETQAGDISAYIPTNV ISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKKVSGTLRLDLASYREL EAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLPVEKQVAILYALTKGYLDDIPV ADIRRFEEEYYMYLDQNHKDLLDGIAKTGNLPADEDFKAAIEGFKRTFAPSN*" /label="atpA CDS" gene complement(3165479..3166987) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /label="atpA gene" CDS complement(3167004..3167549) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit delta, component F1)" /protein_id="NP_391565.1" /db_xref="EnsemblGenomes-Gn:BSU36840" /db_xref="EnsemblGenomes-Tr:CAB15701" /db_xref="GOA:P37811" /db_xref="InterPro:IPR000711" /db_xref="InterPro:IPR020781" /db_xref="InterPro:IPR026015" /db_xref="SubtiList:BG10818" /db_xref="UniProtKB/Swiss-Prot:P37811" /translation="MSGSAVSKRYASALFDIANESAQLNQVEEELIVVKQVFQNEKAL NDVLNHPKVPAAKKKELIQNAFGSLSQSVLNTIFLLIDRHRAAIVPELTDEFIKLANV ARQTEDAIVYSVKPLTDAEMLPLSQVFAKKAGVASLRIRNEVQTDLIGGIKVRIGNRI YDGSVSGKLQRIERQLAGENR*" /label="atpH CDS" gene complement(3167004..3167549) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /label="atpH gene" CDS complement(3167546..3168058) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit b, component F0)" /protein_id="NP_391566.1" /db_xref="EnsemblGenomes-Gn:BSU36850" /db_xref="EnsemblGenomes-Tr:CAB15702" /db_xref="GOA:P37814" /db_xref="InterPro:IPR002146" /db_xref="InterPro:IPR005864" /db_xref="InterPro:IPR028987" /db_xref="SubtiList:BG10817" /db_xref="UniProtKB/Swiss-Prot:P37814" /translation="MSQLPLELGLSFNGGDILFQLLAMLILLALLKKYALGPLLNIMK QREDHIAGEITSAEEKNKEAQQLIEEQRVLLKEARQESQTLIENAKKLGEKQKEEIIQ AARAESERLKEAARTEIVKEKEQAVSALREQVASLSVMIASKVIEKELDEQAQEKLIQ DYLKEVGESR*" /label="atpF CDS" gene complement(3167546..3168058) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /label="atpF gene" S_feature complement(3168059..3168220) /Source="Nicolas_S_feature" /locus_tag="new_3786458_3786619_c" /HighExp="S2, Lbstat, Mal, M40t90, M0t90, G150, MG-0.1, G135, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1425" CDS complement(3168221..3168433) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit c, component F0)" /protein_id="NP_391567.1" /db_xref="EnsemblGenomes-Gn:BSU36860" /db_xref="EnsemblGenomes-Tr:CAB15703" /db_xref="GOA:P37815" /db_xref="InterPro:IPR000454" /db_xref="InterPro:IPR002379" /db_xref="InterPro:IPR005953" /db_xref="InterPro:IPR020537" /db_xref="InterPro:IPR035921" /db_xref="SubtiList:BG10816" /db_xref="UniProtKB/Swiss-Prot:P37815" /translation="MNLIAAAIAIGLGALGAGIGNGLIVSRTVEGIARQPEAGKELRT LMFMGIALVEALPIIAVVIAFLAFFG*" /label="atpE CDS" gene complement(3168221..3168433) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /label="atpE gene" CDS complement(3168479..3169213) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit a, component F0)" /protein_id="NP_391568.1" /db_xref="EnsemblGenomes-Gn:BSU36870" /db_xref="EnsemblGenomes-Tr:CAB15704" /db_xref="GOA:P37813" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="SubtiList:BG10815" /db_xref="UniProtKB/Swiss-Prot:P37813" /translation="MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIR PGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSITIGH ELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEF ANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSL FIGAIQAFIFTMLTMVYMSHKISHDH*" /label="atpB CDS" gene complement(3168479..3169213) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /label="atpB gene" promotor_no_box 3169027..3169127 /Source="Nicolas_upshift_promotors" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3169087 /Source="Nicolas_upshifts" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3169221..3169604) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /function="16.1: Circulate" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12917488, 15849754, 16850406, 23123906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12917488, 15849754, 16850406, 23123906; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit i)" /protein_id="NP_391569.1" /db_xref="EnsemblGenomes-Gn:BSU36880" /db_xref="EnsemblGenomes-Tr:CAB15705" /db_xref="GOA:P37816" /db_xref="InterPro:IPR005598" /db_xref="SubtiList:BG10814" /db_xref="UniProtKB/Swiss-Prot:P37816" /translation="MDDPKLTFSRQRKYLLFILAVYVLGYGLTAYKTVFLGLILGTVF SLFNFLLLVRRMNAFDRAVEKGKSIRSLGSAARWCNAILAVAVAYKNPEYFHMASTVI GLMTIYPVIMIDSFIQLKRSSMEER*" /label="atpI CDS" gene complement(3169221..3169604) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /label="atpI gene" misc_feature complement(3169293..3169311) /Source="Nicolas_upshift_promotors" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3169295) /Source="Nicolas_upshifts" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3169605..3169875) /Source="Nicolas_S_feature" /locus_tag="new_3788004_3788274_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, UNK1, B60, G135, G180, G150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.96" /label="S1426" promotor_-35 3169837..3169846 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3169846 /Source="Nicolas_upshifts" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3169851..3169870) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" promotor_-10 3169860..3169879 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3169875) /Source="Nicolas_upshifts" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3169877..3169998) /Source="Nicolas_S_feature" /locus_tag="new_3788276_3788397_c" /HighExp="Etha, G180, H2O2, G135, Oxctl, G150, LBGexp, dia15, B36, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.96" /label="S1427" promotor_-35 complement(3169883..3169890) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3170027..3170656) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /EC_number="2.4.2.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7798145, 15689504, 15716449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 15689504, 15716449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil phosphoribosyltransferase" /protein_id="NP_391570.1" /db_xref="EnsemblGenomes-Gn:BSU36890" /db_xref="EnsemblGenomes-Tr:CAB15706" /db_xref="GOA:P39149" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="SubtiList:BG10945" /db_xref="UniProtKB/Swiss-Prot:P39149" /translation="MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEI TRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGL YRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCL VAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK*" /label="upp CDS" gene complement(3170027..3170656) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /label="upp gene" downshifts complement(3170043) /Source="Nicolas_upshifts" /id="D1907" /incds=0 /nref=180 /ntot=252 /MaxReadThrough="5.83241" /MaxDrop="5.91252" /score="1.39547358" /energy="-7.3" /TU="U2900,U2901" /idTUdmin="U2900" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3170700..3170719) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" upshifts complement(3170723) /Source="Nicolas_upshifts" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" promotor_-35 complement(3170734..3170741) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3170791..3172038) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /EC_number="2.1.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine hydroxymethyltransferase" /protein_id="NP_391571.1" /db_xref="EnsemblGenomes-Gn:BSU36900" /db_xref="EnsemblGenomes-Tr:CAB15707" /db_xref="GOA:P39148" /db_xref="InterPro:IPR001085" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR019798" /db_xref="SubtiList:BG10944" /db_xref="UniProtKB/Swiss-Prot:P39148" /translation="MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQG SVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVY FTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYAD FVTTTTHKTLRGPRGGMILCREEFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQD DFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEI GITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGK LEEARQRVAALTDKFPLYKELDY*" /label="glyA CDS" gene complement(3170791..3172038) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /label="glyA gene" downshifts complement(3170814) /Source="Nicolas_upshifts" /id="D1908" /incds=0 /nref=183 /ntot=229 /MaxReadThrough="5.99283" /MaxDrop="6.62881" /score="22.1245386" /energy="-15.8" /TU="U2901" /idTUdmin="U2902" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3172080..3172099) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3172097) /Source="Nicolas_upshifts" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3172099..3172183) /Source="Nicolas_S_feature" /locus_tag="new_3790498_3790582_c" /HighExp="dia5, C90, dia15, Diami, Lbtran, LPhT, M40t45, H2O2, BI, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1428" promotor_-35 complement(3172114..3172119) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3172228) /Source="Nicolas_upshifts" /id="D1909" /incds=0 /nref=3 /ntot=12 /MaxReadThrough="7.23859" /MaxDrop="5.0386" /score="-3.86767322" /energy="-4.3" /TU="U2902,U2903" /idTUdmin="U2904" /TUdmin=1137 /isTUend="FALSE" /label="downshifts" CDS complement(3172245..3172787) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391572.1" /db_xref="EnsemblGenomes-Gn:BSU36910" /db_xref="EnsemblGenomes-Tr:CAB15708" /db_xref="InterPro:IPR006340" /db_xref="InterPro:IPR028345" /db_xref="SubtiList:BG10943" /db_xref="UniProtKB/Swiss-Prot:P39157" /translation="MNELKQTWKTMLSEFQDQAELKQDQLFVLGCSTSEVAGSRIGTS GSVDIAESIYSGLAELREKTGIHLAFQCCEHLNRALVVEAETAKLFRLPTVSAVPVPK AGGAMASYAFKQMKSPVLVETIQADAGIDIGDTFIGMHLKPVAVPVRVSQNSLGSAHV TLARTRPKLIGGVRAVYECE*" /label="ywlG CDS" gene complement(3172245..3172787) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /label="ywlG gene" CDS complement(3172800..3173249) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /EC_number="5.3.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15755726, 15995210, 18640127, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 15995210, 18640127, 19446032; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose 5-phosphate epimerase (promiscuous)" /protein_id="NP_391573.1" /db_xref="EnsemblGenomes-Gn:BSU36920" /db_xref="EnsemblGenomes-Tr:CAB15709" /db_xref="GOA:P39156" /db_xref="InterPro:IPR003500" /db_xref="InterPro:IPR004785" /db_xref="InterPro:IPR036569" /db_xref="SubtiList:BG10942" /db_xref="UniProtKB/Swiss-Prot:P39156" /translation="MKVAIASDHGGVHIRNEIKELMDELQIEYIDMGCDCGSGSVDYP DYAFPVAEKVVSGEVDRGILICGTGIGMSISANKVKGIRCALAHDTFSAKATREHNDT NILAMGERVIGPGLAREIAKIWLTTEFTGGRHQTRIGKISDYEEKNL*" /label="rpiB CDS" gene complement(3172800..3173249) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /label="rpiB gene" S_feature complement(3173250..3173349) /Source="Nicolas_S_feature" /locus_tag="new_3791649_3791748_c" /HighExp="Diami, dia5, C90, dia15, LPhT, M40t45, LBGtran, Lbtran, T-0.40H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.68276199999999998" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1429" promotor_-10 complement(3173341..3173360) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-10" upshifts complement(3173349) /Source="Nicolas_upshifts" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="upshifts" promotor_-35 complement(3173374..3173381) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-35" CDS complement(3173406..3173858) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /EC_number="3.9.1.2" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210, 22517742, 24825175, 25610436, 27524296" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210, 22517742, 24825175, 25610436, 27524296; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress)" /protein_id="NP_391574.1" /db_xref="EnsemblGenomes-Gn:BSU36930" /db_xref="EnsemblGenomes-Tr:CAB15710" /db_xref="GOA:P39155" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1ZGG" /db_xref="PDB:4ETI" /db_xref="PDB:4ETN" /db_xref="PDB:4KK3" /db_xref="PDB:4KK4" /db_xref="SubtiList:BG10941" /db_xref="UniProtKB/Swiss-Prot:P39155" /translation="MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPN GKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKV FTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR*" /label="prpB CDS" gene complement(3173406..3173858) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /label="prpB gene" promotor_-10 complement(3173875..3173894) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-10" upshifts complement(3173893) /Source="Nicolas_upshifts" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="upshifts" promotor_-35 complement(3173909..3173912) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-35" CDS complement(3173934..3174491) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 25774656, 25794618, 26076491; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="manganese efflux pump" /protein_id="NP_391575.1" /db_xref="EnsemblGenomes-Gn:BSU36940" /db_xref="EnsemblGenomes-Tr:CAB15711" /db_xref="GOA:P39154" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR022929" /db_xref="SubtiList:BG10940" /db_xref="UniProtKB/Swiss-Prot:P39154" /translation="MSDLFIGELITLSIMAFALGMDAFSVGLGMGMVKLRKKQIFYIG FIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMS PAGPGLLLFAIGVSLDSFSVGLSLGIYGSHPLLTITLFGLFSMMLTWLGLLVGKQVQS WLGTYSEALGGIILIVFGLKLLLPI*" /label="mntP CDS" gene complement(3173934..3174491) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /label="mntP gene" promotor_-10 complement(3174518..3174536) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-10" upshifts complement(3174531) /Source="Nicolas_upshifts" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="upshifts" promotor_-35 complement(3174552..3174557) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-35" CDS complement(3174570..3175610) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; threonine-dependent ADP-forming ATPase" /protein_id="NP_391576.1" /db_xref="EnsemblGenomes-Gn:BSU36950" /db_xref="EnsemblGenomes-Tr:CAB15712" /db_xref="GOA:P39153" /db_xref="InterPro:IPR005145" /db_xref="InterPro:IPR006070" /db_xref="InterPro:IPR010923" /db_xref="InterPro:IPR017945" /db_xref="SubtiList:BG10939" /db_xref="UniProtKB/Swiss-Prot:P39153" /translation="MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGL GANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGAL TLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIH VDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTE EKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMN RLMKAAGGRVIR*" /label="tsaC CDS" gene complement(3174570..3175610) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /label="tsaC gene" downshifts complement(3174575) /Source="Nicolas_upshifts" /id="D1910" /incds=0 /nref=4 /ntot=166 /MaxReadThrough="2.08557" /MaxDrop="2.98653" /score="-6.24994287" /energy="-9.8" /TU="NA" /idTUdmin="U2905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3175611..3175675) /Source="Nicolas_S_feature" /locus_tag="new_3794010_3794074_c" /HighExp="dia15, Diami, C90, LBGstat, Heat, LBGtran, dia5, LBGexp, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1430" promotor_-10 complement(3175665..3175684) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3175675) /Source="Nicolas_upshifts" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3175677..3175766) /Source="Nicolas_S_feature" /locus_tag="new_3794076_3794165_c" /HighExp="S3, M9-stat, Etha, LoTm, T5.0H, S7, S8, S4, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1431" promotor_-35 complement(3175700..3175704) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3175767..3176210) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391577.1" /db_xref="EnsemblGenomes-Gn:BSU36960" /db_xref="EnsemblGenomes-Tr:CAB15713" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10938" /db_xref="UniProtKB/Swiss-Prot:P39152" /translation="MFYQLRVAREKDGDVLEAFLKQAKTSYEGVKEGFTQFLMLEDSE KNIAGCLGIEKISCDQGLLRSLVISDKLHQGHIVTLFQSMEVLCEKHQIKTVYLVANQ HSSADFLTAMGFERAESVPEELFSSDHFCESRQTEGAVLMKKASG*" /label="ywlB CDS" gene complement(3175767..3176210) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /label="ywlB gene" CDS complement(3176277..3176951) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15044948, 16824103, 18378688, 20802044, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15044948, 16824103, 18378688, 20802044, 22111992; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator signal of pro-sigma(E) spoIIGA endopeptidase (stage II sporulation)" /protein_id="NP_391578.1" /db_xref="EnsemblGenomes-Gn:BSU36970" /db_xref="EnsemblGenomes-Tr:CAB15714" /db_xref="GOA:P39151" /db_xref="InterPro:IPR014202" /db_xref="SubtiList:BG10937" /db_xref="UniProtKB/Swiss-Prot:P39151" /translation="MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIR LRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKET MEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLC FLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEW ISDLFS*" /label="spoIIR CDS" gene complement(3176277..3176951) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /label="spoIIR gene" promotor_-10 complement(3176713..3176731) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3176720) /Source="Nicolas_upshifts" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3176746..3176752) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3176983..3177000) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3176984) /Source="Nicolas_upshifts" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3177016..3177021) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3177057 /Source="Nicolas_upshifts" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3177061..3177080 /Source="Nicolas_upshift_promotors" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3177092..3177454 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391579.1" /db_xref="EnsemblGenomes-Gn:BSU36980" /db_xref="EnsemblGenomes-Tr:CAB15715" /db_xref="GOA:P39150" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG10936" /db_xref="UniProtKB/Swiss-Prot:P39150" /translation="MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLI FALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVL TALIYWIWDSVLLQKKEA*" /label="ywlA CDS" gene 3177092..3177454 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /label="ywlA gene" downshifts complement(3177467) /Source="Nicolas_upshifts" /id="D1911" /incds=0 /nref=27 /ntot=242 /MaxReadThrough="2.64328" /MaxDrop="5.72616" /score="26.8558862" /energy="-11.3" /TU="U2910" /idTUdmin="U2909" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3177471..3177758) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391580.1" /db_xref="EnsemblGenomes-Gn:BSU36990" /db_xref="EnsemblGenomes-Tr:CAB15716" /db_xref="GOA:P45874" /db_xref="InterPro:IPR035167" /db_xref="SubtiList:BG11317" /db_xref="UniProtKB/Swiss-Prot:P45874" /translation="MKKALTAGILLIAIESMIGTIFPQALSYEAIFGVASLVLVGLAI ITSGLAVSGSDQRANYHSETKEGRTSRMKMAAAFFVAAIPSILCYLLTILF*" /label="ywkF CDS" gene complement(3177471..3177758) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /label="ywkF gene" S_feature complement(3177759..3177817) /Source="Nicolas_S_feature" /locus_tag="new_3796158_3796216_c" /HighExp="S6, S8, S7, BT, G135, G180, Paraq, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1432" promotor_-10 complement(3177815..3177834) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3177818..3178684) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /EC_number="2.1.1.297" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 16364916, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine methylase of release factor 1 (and perhaps others) at a GGQ site" /protein_id="NP_391581.1" /db_xref="EnsemblGenomes-Gn:BSU37000" /db_xref="EnsemblGenomes-Tr:CAB15717" /db_xref="GOA:P45873" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004556" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR019874" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11316" /db_xref="UniProtKB/Swiss-Prot:P45873" /translation="MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASL QEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFH LLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAE KLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDG GDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGK DRTICALIHKNK*" /label="prmC CDS" gene complement(3177818..3178684) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /label="prmC gene" upshifts complement(3177831) /Source="Nicolas_upshifts" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3177847..3177856) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3178686..3179756) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /experiment="publication(s) with functional evidences, PMID:2186375, 1408743, 10446248, 12237459, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2186375, 1408743, 10446248, 12237459, 12682299; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 1" /protein_id="NP_391582.1" /db_xref="EnsemblGenomes-Gn:BSU37010" /db_xref="EnsemblGenomes-Tr:CAB15718" /db_xref="GOA:P45872" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004373" /db_xref="InterPro:IPR005139" /db_xref="SubtiList:BG11244" /db_xref="UniProtKB/Swiss-Prot:P45872" /translation="MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQET VDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPK DPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEK DIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARI YDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGK LDEVVEALIVEDQASKLQQSEG*" /label="prfA CDS" gene complement(3178686..3179756) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /label="prfA gene" downshifts complement(3178689) /Source="Nicolas_upshifts" /id="D1912" /incds=0 /nref=23 /ntot=212 /MaxReadThrough="5.17118" /MaxDrop="3.44681" /score="-9.55295942" /energy="-10.5" /TU="U2910" /idTUdmin="U2912" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" downshifts 3179757 /Source="Nicolas_upshifts" /id="D1913" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.13519" /MaxDrop="4.28706" /score="36.3991981" /energy="-10.4" /TU="NA" /idTUdmin="U2911" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3179784..3179803) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3179808) /Source="Nicolas_upshifts" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3179810..3179921) /Source="Nicolas_S_feature" /locus_tag="new_3798209_3798320_c" /HighExp="S6, S8, S7, BT, S5, Etha, B36, C30, S4, GM 25" /AntisenseName="ywkD" /AntisenseCor="-0.43140174721346802" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.927" /TUlongSig="NA" /TUlongPSig="NA" /label="S1433" promotor_-35 complement(3179817..3179823) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3179853..3179872 /Source="Nicolas_upshift_promotors" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3179867 /Source="Nicolas_upshifts" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3179882..3180268 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391583.1" /db_xref="EnsemblGenomes-Gn:BSU37020" /db_xref="EnsemblGenomes-Tr:CAB15719" /db_xref="GOA:P45871" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11315" /db_xref="UniProtKB/Swiss-Prot:P45871" /translation="MLLKSIHHIAIICSDYEKSKAFYVHKLGFQVIQETYREERGSYK LDLSLNGSYVIELFSFPDPPERQTRPEAAGLRHLAFTVGSLDKAVQELHEKGIETEPI RTDPLTGKRFTFFFDPDQLPLELYEQ*" /label="ywkD CDS" gene 3179882..3180268 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /label="ywkD gene" promotor_-10 complement(3179903..3179921) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-10" upshifts complement(3179921) /Source="Nicolas_upshifts" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="upshifts" promotor_-35 complement(3179935..3179942) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-35" promotor_-35 3180336..3180344 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3180355..3180373 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3180356 /Source="Nicolas_upshifts" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3180390..3180944 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15780934, 17139259, 19478798, 22720735, 27059541, 27085804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15780934, 17139259, 19478798, 22720735, 27059541, 27085804; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome-pole-anchoring protein RacA" /protein_id="NP_391584.1" /db_xref="EnsemblGenomes-Gn:BSU37030" /db_xref="EnsemblGenomes-Tr:CAB15720" /db_xref="GOA:P45870" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR023522" /db_xref="PDB:5I41" /db_xref="PDB:5I44" /db_xref="SubtiList:BG11314" /db_xref="UniProtKB/Swiss-Prot:P45870" /translation="MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVK VLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQ DESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIP ETAAASEKTKTRKKPLLSLFKFQT*" /label="racA CDS" gene 3180390..3180944 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /label="racA gene" misc_feature 3180874..3180878 /Source="Nicolas_upshift_promotors" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3180879 /Source="Nicolas_upshifts" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3180923 /Source="Nicolas_upshifts" /id="D1914" /incds=0 /nref=213 /ntot=274 /MaxReadThrough="0.82868" /MaxDrop="8.28021" /score="36.3991981" /energy="-10.4" /TU="U2913" /idTUdmin="U2914" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3180978..3181937) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12949160, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391585.1" /db_xref="EnsemblGenomes-Gn:BSU37040" /db_xref="EnsemblGenomes-Tr:CAB15721" /db_xref="GOA:P45869" /db_xref="InterPro:IPR004776" /db_xref="InterPro:IPR014024" /db_xref="SubtiList:BG11313" /db_xref="UniProtKB/Swiss-Prot:P45869" /translation="MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKY ALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFS LNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNE ESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGV ALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAF PGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA*" /label="ywkB CDS" gene complement(3180978..3181937) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /label="ywkB gene" downshifts complement(3181000) /Source="Nicolas_upshifts" /id="D1915" /incds=0 /nref=36 /ntot=74 /MaxReadThrough="2.86006" /MaxDrop="4.78642" /score="20.048754" /energy="-10.4" /TU="U2916" /idTUdmin="U2917" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3181975..3181993) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3181989) /Source="Nicolas_upshifts" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3182008..3182014) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3182019..3183767) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12949160, 16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949160, 16788182, 20933603, 22740702, 23136871, 24325460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_391586.1" /db_xref="EnsemblGenomes-Gn:BSU37050" /db_xref="EnsemblGenomes-Tr:CAB15722" /db_xref="GOA:P45868" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11312" /db_xref="UniProtKB/Swiss-Prot:P45868" /translation="MGYYLTWLTISRKKEICLNNIKKTKEGHLETTLRGKEVLSIPTL NKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQPDRLRQNVYLSDLANRN EVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYLSIDNIDGIEKAFENL HATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGIDPSRVIPVVLDVG TNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAALKFFPKALLHWEDLGNKNARNI MKKYNHEILTFNDDIQGTGAITLAGVLAAMKKTGASIKDQRVVIFGAGSAGIGIADQI RDTMVLAGLSEEEANKRFYTLDYRGLLTEDIEGILDFQKPYLRNADEVKDWKRDEKGQ IPFDEVVRQAKPTILIGTSGVSGAFTEEIVKEMASHVDRPVIMPMSNPTHLAEAVPED LFKWTDGKVLIATGSPFDNVEYNGVSYEIGQSNNAFAFPGLGLGSIVAEARIITPAMF AATADAIAEMVDLETPGAGLLPSIDKLQEVSIQVAIAVAEAAIKDGVANRQPEDVKQA VLDAMWTPEYKKVIAK*" /label="maeA CDS" gene complement(3182019..3183767) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /label="maeA gene" promotor_-10 complement(3182493..3182511) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3182501) /Source="Nicolas_upshifts" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3182526..3182532) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3183768..3183858) /Source="Nicolas_S_feature" /locus_tag="new_3802167_3802257_c" /HighExp="GM 25, GM 15, GM 60, GM 90, GM 120, MG-0.2, MG 15, GM 45, MG-0.1, GM 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1434" promotor_-10 complement(3183842..3183861) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3183858) /Source="Nicolas_upshifts" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3183875..3183882) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3184001) /Source="Nicolas_upshifts" /id="D1916" /incds=0 /nref=11 /ntot=126 /MaxReadThrough="2.81368" /MaxDrop="3.39095" /score="20.3711149" /energy="-7.5" /TU="NA" /idTUdmin="U2918" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(3184006..3184593) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /EC_number="2.7.1.21" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2423635, 17132103; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidine kinase" /protein_id="NP_391587.1" /db_xref="EnsemblGenomes-Gn:BSU37060" /db_xref="EnsemblGenomes-Tr:CAB15723" /db_xref="GOA:Q03221" /db_xref="InterPro:IPR001267" /db_xref="InterPro:IPR020633" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10419" /db_xref="UniProtKB/Swiss-Prot:Q03221" /translation="MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKP VIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLS SLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK*" /label="tdk CDS" gene complement(3184006..3184593) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /label="tdk gene" CDS complement(3184682..3184882) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_391588.1" /db_xref="EnsemblGenomes-Gn:BSU37070" /db_xref="EnsemblGenomes-Tr:CAB15724" /db_xref="GOA:Q03223" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027491" /db_xref="InterPro:IPR034704" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10417" /db_xref="UniProtKB/Swiss-Prot:Q03223" /translation="MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYT GRQKFASADGRVDRFNKKYGLK*" /label="rpmEA CDS" gene complement(3184682..3184882) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /label="rpmEA gene" downshifts complement(3184695) /Source="Nicolas_upshifts" /id="D1917" /incds=0 /nref=268 /ntot=279 /MaxReadThrough="5.35148" /MaxDrop="6.82076" /score="15.63162" /energy="-10.3" /TU="U2918,U2919" /idTUdmin="U2921" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3184883..3184960) /Source="Nicolas_S_feature" /locus_tag="new_3803282_3803359_c" /HighExp="HPh, LPh, LPhT, GM 45, Paraq, MG 45, MG 60, aero, LBGexp, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1435" promotor_-10 complement(3184956..3184975) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3184960) /Source="Nicolas_upshifts" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3184989..3184996) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3185001..3186284) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10027981, 16014871, 18852477, 28520932, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10027981, 16014871, 18852477, 28520932, 28723971; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcriptional terminator Rho" /protein_id="NP_391589.2" /db_xref="EnsemblGenomes-Gn:BSU37080" /db_xref="EnsemblGenomes-Tr:CAB15725" /db_xref="GOA:Q03222" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004665" /db_xref="InterPro:IPR011112" /db_xref="InterPro:IPR011113" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036269" /db_xref="SubtiList:BG10416" /db_xref="UniProtKB/Swiss-Prot:Q03222" /translation="MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKA NAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGK VRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRI MDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDI ERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLV IPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEF KGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDF AEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR*" /label="rho CDS" gene complement(3185001..3186284) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /label="rho gene" S_feature complement(3186285..3186587) /Source="Nicolas_S_feature" /locus_tag="new_3804684_3804986_c" /HighExp="H2O2, Cold, G135, HPh, G180, G150, LBGstat, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1436" CDS complement(3186315..3186476) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 20525796" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514010.1" /db_xref="EnsemblGenomes-Gn:BSU37089" /db_xref="EnsemblGenomes-Tr:CCQ48606" /db_xref="UniProtKB/TrEMBL:L8EA05" /translation="MFLSSLPSKLIKTILLTKAPIMGGSVTDRSSFMLKKECALADVV QKQQMTCSE*" /label="hypothetical protein CDS" gene complement(3186315..3186476) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /label="gene" promotor_-10 complement(3186567..3186586) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3186587) /Source="Nicolas_upshifts" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3186602..3186606) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3186691..3187656) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /EC_number="3.1.3.11" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose 1,6-bisphosphatase class II" /protein_id="NP_391590.1" /db_xref="EnsemblGenomes-Gn:BSU37090" /db_xref="EnsemblGenomes-Tr:CAB15726" /db_xref="GOA:Q03224" /db_xref="InterPro:IPR004464" /db_xref="SubtiList:BG10415" /db_xref="UniProtKB/Swiss-Prot:Q03224" /translation="MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVF DTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALT VIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVAT ILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSA VALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGE LLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP*" /label="glpX CDS" gene complement(3186691..3187656) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /label="glpX gene" downshifts complement(3186697) /Source="Nicolas_upshifts" /id="D1918" /incds=0 /nref=56 /ntot=196 /MaxReadThrough="5.42698" /MaxDrop="5.21817" /score="-2.15106481" /energy="-10.2" /TU="U2921,U2922" /idTUdmin="U2922" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 3187273..3187282 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3187295..3187314 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3187303 /Source="Nicolas_upshifts" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3187687..3188976) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /EC_number="2.5.1.7" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14763982, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14763982, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391591.2" /db_xref="EnsemblGenomes-Gn:BSU37100" /db_xref="EnsemblGenomes-Tr:CAB15727" /db_xref="GOA:P19670" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10414" /db_xref="UniProtKB/Swiss-Prot:P19670" /translation="MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGL PEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAML GRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGV KELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETS DDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKH IDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGL EHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS*" /label="murAB CDS" gene complement(3187687..3188976) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /label="murAB gene" S_feature complement(3188977..3189336) /Source="Nicolas_S_feature" /locus_tag="new_3807376_3807735_c" /HighExp="dia5, Fru, UNK1, Glucon, HiOs, T-5.40H, nit, SMM, MG 120, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16076699999999999" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1437" CDS complement(3189355..3189993) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /EC_number="2.2.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 12469342, 22212631, 23468065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 12469342, 22212631, 23468065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transaldolase" /protein_id="NP_391592.3" /db_xref="EnsemblGenomes-Gn:BSU37110" /db_xref="EnsemblGenomes-Tr:CAB15728" /db_xref="GOA:P19669" /db_xref="InterPro:IPR001585" /db_xref="InterPro:IPR004731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018225" /db_xref="InterPro:IPR022999" /db_xref="InterPro:IPR033919" /db_xref="PDB:3R8R" /db_xref="SubtiList:BG10413" /db_xref="UniProtKB/Swiss-Prot:P19669" /translation="MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRL REITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLG IKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQ IIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK*" /label="tal CDS" gene complement(3189355..3189993) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /label="tal gene" downshifts complement(3189381) /Source="Nicolas_upshifts" /id="D1919" /incds=0 /nref=6 /ntot=65 /MaxReadThrough="6.97243" /MaxDrop="4.038" /score="-6.93331064" /energy="-18.4" /TU="U2921,U2922" /idTUdmin="U2926" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" S_feature complement(3189994..3190112) /Source="Nicolas_S_feature" /locus_tag="new_3808393_3808511_c" /HighExp="dia5, LBGtran, M40t45, Lbtran, Mt0, M40t90, M0t45, Lbstat, Lbexp, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1438" CDS complement(3190113..3190970) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /EC_number="4.1.2.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphate aldolase" /protein_id="NP_391593.1" /db_xref="EnsemblGenomes-Gn:BSU37120" /db_xref="EnsemblGenomes-Tr:CAB15729" /db_xref="GOA:P13243" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10412" /db_xref="UniProtKB/Swiss-Prot:P13243" /translation="MPLVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSP VILGVSEGAGRYMGGFKTVVAMVKALMEEYKVTVPVAIHLDHGSSFESCAKAIHAGFT SVMIDASHHPFEENVATTAKVVELAHFHGVSVEAELGTVGGQEDDVIAEGVIYADPKE CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGKSTGLPLVLHGGTGIPTAD IKKSISLGTAKINVNTENQISSAKAVRETLAAKPDEYDPRKYLGPAREAIKETVIGKM REFGSSNQA*" /label="fbaA CDS" gene complement(3190113..3190970) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /label="fbaA gene" S_feature complement(3190971..3191097) /Source="Nicolas_S_feature" /locus_tag="new_3809370_3809496_c" /HighExp="C90, Lbtran, LBGtran, dia5, LBGexp, aero, M0t90, Glu, Lbexp, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1439" promotor_-10 complement(3191079..3191098) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-10" upshifts complement(3191097) /Source="Nicolas_upshifts" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="upshifts" promotor_-35 complement(3191112..3191119) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-35" CDS complement(3191151..3191525) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator of sporulation initiation" /protein_id="NP_391594.1" /db_xref="EnsemblGenomes-Gn:BSU37130" /db_xref="EnsemblGenomes-Tr:CAB15730" /db_xref="GOA:P06628" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="PDB:1F51" /db_xref="PDB:1FSP" /db_xref="PDB:1NAT" /db_xref="PDB:1PEY" /db_xref="PDB:1PUX" /db_xref="PDB:1SRR" /db_xref="PDB:2FSP" /db_xref="PDB:2FTK" /db_xref="PDB:2JVI" /db_xref="PDB:2JVJ" /db_xref="PDB:2JVK" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG10411" /db_xref="UniProtKB/Swiss-Prot:P06628" /translation="MMNEKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVT KERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF AKPFDIDEIRDAVKKYLPLKSN*" /label="spo0F CDS" gene complement(3191151..3191525) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /label="spo0F gene" promotor_-10 complement(3191565..3191583) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3191579) /Source="Nicolas_upshifts" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="upshifts" S_feature complement(3191581..3192220) /Source="Nicolas_S_feature" /locus_tag="new_3809980_3810619_c" /HighExp="dia15, Diami, dia5, G135, Etha, G150, G180, Salt, H2O2, Paraq" /AntisenseName="ywjG" /AntisenseCor="0.58536525532649697" /AntisenseRegPval="-25.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1440" promotor_-35 3191582..3191585 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3191594..3191602) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" promotor_-10 3191601..3191620 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3191614 /Source="Nicolas_upshifts" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3191628..3191633 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3191649..3191668 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3191659 /Source="Nicolas_upshifts" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" CDS 3191691..3192212 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391595.1" /db_xref="EnsemblGenomes-Gn:BSU37140" /db_xref="EnsemblGenomes-Tr:CAB15731" /db_xref="InterPro:IPR019676" /db_xref="SubtiList:BG11053" /db_xref="UniProtKB/Swiss-Prot:P06629" /translation="MLKIFTTQLTGIFSRIQDKESDAIEDGARLLAQAVISGHSIYLY GANELQGVFYEATESKEPFPSVKAFPENAEEVTESDRVLMFCSGTGTAEEQELAKELY EKGAGVVCVSPAAKDSAGIEQYCDVHIDSKLKMPLVPDEDGTRYGFPSLMTALYVYHA LSFTLKEILQEYA*" /label="ywjG CDS" gene 3191691..3192212 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /label="ywjG gene" promotor_-35 3192155..3192158 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3192173..3192192 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3192187 /Source="Nicolas_upshifts" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3192210..3192229) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3192220) /Source="Nicolas_upshifts" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="upshifts" downshifts 3192231 /Source="Nicolas_upshifts" /id="D1920" /incds=0 /nref=191 /ntot=242 /MaxReadThrough="1.98527" /MaxDrop="5.8354" /score="11.5531593" /energy="-11.9" /TU="NA" /idTUdmin="U2923" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3192244..3192251) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" CDS complement(3192294..3193901) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /EC_number="6.3.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11544212, 15252202, 17158658, 17302819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544212, 15252202, 17158658, 17302819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CTP synthetase" /protein_id="NP_391596.1" /db_xref="EnsemblGenomes-Gn:BSU37150" /db_xref="EnsemblGenomes-Tr:CAB15743" /db_xref="GOA:P13242" /db_xref="InterPro:IPR004468" /db_xref="InterPro:IPR017456" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033828" /db_xref="SubtiList:BG10410" /db_xref="UniProtKB/Swiss-Prot:P13242" /translation="MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYI NVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKE RRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ MKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPIS QDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSE WKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEV TENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYA RNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVY QDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHP EFKSRPTRPQPLFKGFIGASVEAANQK*" /label="pyrG CDS" gene complement(3192294..3193901) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /label="pyrG gene" downshifts complement(3192307) /Source="Nicolas_upshifts" /id="D1921" /incds=0 /nref=222 /ntot=259 /MaxReadThrough="2.2929" /MaxDrop="8.17874" /score="18.9699606" /energy="-12.1" /TU="NA" /idTUdmin="U2927" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3193902..3194089) /Source="Nicolas_S_feature" /locus_tag="new_3812301_3812488_c" /HighExp="LBGexp, Lbexp, dia0, G150, G135, G180, Paraq, Oxctl, dia15, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1441" promotor_-10 complement(3194077..3194096) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3194089) /Source="Nicolas_upshifts" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3194111..3194118) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3194143..3194664) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase (delta subunit) and transcriptional repressor" /protein_id="NP_391597.1" /db_xref="EnsemblGenomes-Gn:BSU37160" /db_xref="EnsemblGenomes-Tr:CAB15744" /db_xref="GOA:P12464" /db_xref="InterPro:IPR007759" /db_xref="InterPro:IPR029757" /db_xref="PDB:2KRC" /db_xref="PDB:2M4K" /db_xref="PDB:4NC7" /db_xref="PDB:4NC8" /db_xref="SubtiList:BG10409" /db_xref="UniProtKB/Swiss-Prot:P12464" /translation="MGIKQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLL GVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKA KKAVEEDLDLDEFEEIDEDDLDLDEVEEELDLEADDFDEEDLDEDDDDLEIEEDIIDE DDEDYDDEEEEIK*" /label="rpoE CDS" gene complement(3194143..3194664) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /label="rpoE gene" downshifts complement(3194199) /Source="Nicolas_upshifts" /id="D1922" /incds=0 /nref=7 /ntot=182 /MaxReadThrough="6.49215" /MaxDrop="3.2129" /score="19.8764263" /energy="-19.4" /TU="U2928,U2929" /idTUdmin="U2927" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" S_feature complement(3194665..3194767) /Source="Nicolas_S_feature" /locus_tag="new_3813064_3813166_c" /HighExp="H2O2, Paraq, Oxctl, LBGexp, G180, dia15, dia0, Lbexp, BMM, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1442" promotor_-10 complement(3194748..3194767) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3194767) /Source="Nicolas_upshifts" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3194769..3194846) /Source="Nicolas_S_feature" /locus_tag="new_3813168_3813245_c" /HighExp="T0.30H, S8, S7, S6, S4, S3, S5, Sw, BC, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1443" promotor_-35 complement(3194783..3194786) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3194847..3195986) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase" /protein_id="NP_391598.1" /db_xref="EnsemblGenomes-Gn:BSU37170" /db_xref="EnsemblGenomes-Tr:CAB15745" /db_xref="GOA:P45867" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG11239" /db_xref="UniProtKB/Swiss-Prot:P45867" /translation="MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFRE MANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFG TEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCV VPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIA EQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEA VQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD*" /label="acdA CDS" gene complement(3194847..3195986) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /label="acdA gene" CDS complement(3195983..3198100) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative iron-sulphur-binding reductase" /protein_id="NP_391599.1" /db_xref="EnsemblGenomes-Gn:BSU37180" /db_xref="EnsemblGenomes-Tr:CAB15746" /db_xref="GOA:P45866" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11311" /db_xref="UniProtKB/Swiss-Prot:P45866" /translation="MSGFLIANALLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQ RFKERLHAIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLS LGPVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTV LLGNGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVY VPQSKHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYA CVECGRCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGN QLAAASAGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKII DLRRYLVLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKK EGKEFEYLFWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGN EFLFQELAEKNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELV KNGKLRPQHPLHETITFHDSCYLGRYNEVYDPPREILKAIPGVQLVEMERSRETGMCC GAGGGLMWMEEETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAKEAEDQVK TYDVVELLAQSVLGADLKMGEKQ*" /label="fadF CDS" gene complement(3195983..3198100) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /label="fadF gene" S_feature complement(3198101..3198159) /Source="Nicolas_S_feature" /locus_tag="new_3816500_3816558_c" /HighExp="T0.30H, S6, BC, S8, S7, Sw, S5, S4, Lbstat, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1444" promotor_-10 complement(3198160..3198179) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3198173) /Source="Nicolas_upshifts" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3198193..3198200) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3198199..3198205 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3198219..3198230 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3198224 /Source="Nicolas_upshifts" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="upshifts" CDS 3198255..3199451 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14973018, 16514141, 18820022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16514141, 18820022; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase (phospholipase D family)" /protein_id="NP_391600.1" /db_xref="EnsemblGenomes-Gn:BSU37190" /db_xref="EnsemblGenomes-Tr:CAB15747" /db_xref="GOA:P45865" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="SubtiList:BG11310" /db_xref="UniProtKB/Swiss-Prot:P45865" /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSD IELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLL LDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIG GFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQ QGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSV RIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANF DKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGR ALSYFL*" /label="clsB CDS" gene 3198255..3199451 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /label="clsB gene" S_feature complement(3198447..3199325) /Source="Nicolas_S_feature" /locus_tag="new_3816846_3817724_c" /HighExp="S4, S5, S3, S6, S7, S8, BT, B36, LoTm, B60" /AntisenseName="clsB" /AntisenseCor="0.84883232203587" /AntisenseRegPval="-75.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1445" promotor_-10 complement(3199315..3199333) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3199326) /Source="Nicolas_upshifts" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3199349..3199354) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3199464..3200426 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /EC_number="3.-.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8614629, 22961846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8614629, 22961846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UV DNA damage repair endonuclease" /protein_id="NP_391601.1" /db_xref="EnsemblGenomes-Gn:BSU37200" /db_xref="EnsemblGenomes-Tr:CAB15748" /db_xref="GOA:P45864" /db_xref="InterPro:IPR004601" /db_xref="InterPro:IPR023520" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11309" /db_xref="UniProtKB/Swiss-Prot:P45864" /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVT KANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKT HQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGN KDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYAN PDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFR QWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS*" /label="uvsE CDS" gene 3199464..3200426 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /label="uvsE gene" promotor_-35 3200440..3200446 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3200461..3200479 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3200461 /Source="Nicolas_upshifts" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="upshifts" CDS 3200507..3200779 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391602.1" /db_xref="EnsemblGenomes-Gn:BSU37210" /db_xref="EnsemblGenomes-Tr:CAB15749" /db_xref="InterPro:IPR035895" /db_xref="SubtiList:BG11308" /db_xref="UniProtKB/Swiss-Prot:P45863" /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKI KSLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL*" /label="ywjC CDS" gene 3200507..3200779 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /label="ywjC gene" downshifts complement(3200513) /Source="Nicolas_upshifts" /id="D1923" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="1.03516" /MaxDrop="5.08765" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 3200769 /Source="Nicolas_upshifts" /id="D1924" /incds=0 /nref=54 /ntot=128 /MaxReadThrough="4.49396" /MaxDrop="7.49636" /score="14.0189582" /energy="-10" /TU="U2932" /idTUdmin="U2930" /TUdmin=178 /isTUend="FALSE" /label="downshifts" S_feature 3200814..3201220 /Source="Nicolas_S_feature" /locus_tag="new_3819213_3819619" /HighExp="Etha, C30, Sw, Gly, C90, M/G, BC, Salt, Fru, G135" /AntisenseName="ywjB" /AntisenseCor="0.2646821361217" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1446" CDS complement(3200821..3201345) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391603.1" /db_xref="EnsemblGenomes-Gn:BSU37220" /db_xref="EnsemblGenomes-Tr:CAB15750" /db_xref="GOA:P45862" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG11307" /db_xref="UniProtKB/Swiss-Prot:P45862" /translation="MERKTVLYIAVSLDGMIAKEDGSIDWLDEFEGEGDNGYSDFYQT VDTVILGRSTYEHVKVLTPVFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLK QEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGT KQFGQAVQLHYVRA*" /label="ywjB CDS" gene complement(3200821..3201345) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /label="ywjB gene" downshifts complement(3200843) /Source="Nicolas_upshifts" /id="D1925" /incds=0 /nref=194 /ntot=239 /MaxReadThrough="1.38978" /MaxDrop="6.19859" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3201355..3203082) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12119303, 12354229, 25652542; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC lipid transporter (ATP-binding protein)" /protein_id="NP_391604.1" /db_xref="EnsemblGenomes-Gn:BSU37230" /db_xref="EnsemblGenomes-Tr:CAB15751" /db_xref="GOA:P45861" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11306" /db_xref="UniProtKB/Swiss-Prot:P45861" /translation="MLRQFFSYYKPYKTLFFLDFFSAIAGGLMELSFPLIVNYFIDTL LPGRDWGLIIATSIGLFAVYALSSALQYIVTYWGHMLGINIETDMRKSLFDHLQKLSF KFYDNNKTGTLMSKLTNDLMYIGEVAHHGPEDLFIAVMTILGAFGVMLFINWQLALLT FIIMPIVIWLALYFNKKMTKAFTTLNKDIGDFSARVENNIGGIRLVQAFGNEAFEKER FAVNNQRFRVTKLSSYKIMAKNGSISYMLTRFVTLFVLLCGTWFVIRGSLSYGEFVAF VLLTNVLFRPIDKINAIIEMYPRGIAGFKSYMELMETEPDIQDSPDSKDVSGLKGNIR YKHVSFGYDDHHNVLNDINLSIQAGETVAFVGPSGAGKSTLCSLLPRFYEASEGDITI DGISIKDMTLSSLRGQIGVVQQDVFLFSGTLRENIAYGRLGASEEDIWQAVKQAHLEE LVHNMPDGLDTMIGERGVKLSGGQKQRLSIARMFLKNPSILILDEATSALDTETEAAI QKALQELSEGRTTLVIAHRLATIKDADRIVVVTNNGIEEQGRHQDLIEAGGLYSRLHQ AQFGQMVHR*" /label="ywjA CDS" gene complement(3201355..3203082) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /label="ywjA gene" promotor_-10 complement(3203116..3203135) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3203130) /Source="Nicolas_upshifts" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3203149..3203155) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3203171..3204673) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /EC_number="2.7.8.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14973018, 15743965, 16514141, 26025016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase" /protein_id="NP_391605.1" /db_xref="EnsemblGenomes-Gn:BSU37240" /db_xref="EnsemblGenomes-Tr:CAB15752" /db_xref="GOA:P45860" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG11305" /db_xref="UniProtKB/Swiss-Prot:P45860" /translation="MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILF SIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLR KLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRK AESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQA GVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRD THLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKE SMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQ YASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVF FTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL*" /label="clsC CDS" gene complement(3203171..3204673) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /label="clsC gene" promotor_-10 complement(3204697..3204715) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3204715) /Source="Nicolas_upshifts" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3204730..3204736) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3204760..3205132) /Source="Nicolas_S_feature" /locus_tag="new_3823159_3823531_c" /HighExp="Lbtran, M40t45, nit, LBGtran, LBGstat, S0, ferm, M0t45, Lbstat, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30294500000000002" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S1447" downshifts complement(3204803) /Source="Nicolas_upshifts" /id="D1926" /incds=0 /nref=4 /ntot=19 /MaxReadThrough="2.94229" /MaxDrop="4.09744" /score="13.5274489" /energy="-11.4" /TU="NA" /idTUdmin="U2935" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3205159..3205830) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (gamma subunit)" /protein_id="NP_391606.1" /db_xref="EnsemblGenomes-Gn:BSU37250" /db_xref="EnsemblGenomes-Tr:CAB15753" /db_xref="GOA:P42177" /db_xref="InterPro:IPR003816" /db_xref="InterPro:IPR023234" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11084" /db_xref="UniProtKB/Swiss-Prot:P42177" /translation="MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKK KLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACT GLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGP WFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVV YRKRS*" /label="narI CDS" gene complement(3205159..3205830) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /label="narI gene" downshifts complement(3205177) /Source="Nicolas_upshifts" /id="D1927" /incds=0 /nref=4 /ntot=13 /MaxReadThrough="6.70789" /MaxDrop="4.50566" /score="27.8375931" /energy="-11.7" /TU="U2935" /idTUdmin="U2935" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(3205827..3206381) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase molybdenum cofactor assembly chaperone NarJ" /protein_id="NP_391607.1" /db_xref="EnsemblGenomes-Gn:BSU37260" /db_xref="EnsemblGenomes-Tr:CAB15754" /db_xref="GOA:P42178" /db_xref="InterPro:IPR003765" /db_xref="InterPro:IPR020945" /db_xref="InterPro:IPR036411" /db_xref="SubtiList:BG11083" /db_xref="UniProtKB/Swiss-Prot:P42178" /translation="MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIR EKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTY EQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAE LLHVLLAALENIGVRESVEGAVQA*" /label="narJ CDS" gene complement(3205827..3206381) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /label="narJ gene" CDS complement(3206407..3207870) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (beta subunit)" /protein_id="NP_391608.1" /db_xref="EnsemblGenomes-Gn:BSU37270" /db_xref="EnsemblGenomes-Tr:CAB15755" /db_xref="GOA:P42176" /db_xref="InterPro:IPR006547" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR029263" /db_xref="SubtiList:BG11082" /db_xref="UniProtKB/Swiss-Prot:P42176" /translation="MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNV ETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEP WNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQK MEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWR YCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADK VEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDW KIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQL LTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAK YDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF*" /label="narH CDS" gene complement(3206407..3207870) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /label="narH gene" CDS complement(3207860..3211546) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /EC_number="1.7.5.1" /EC_number="1.7.99.4" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11289299, 7557333, 7860592, 8846791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (alpha subunit)" /protein_id="NP_391609.2" /db_xref="EnsemblGenomes-Gn:BSU37280" /db_xref="EnsemblGenomes-Tr:CAB15756" /db_xref="GOA:P42175" /db_xref="InterPro:IPR006468" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="InterPro:IPR028189" /db_xref="SubtiList:BG11081" /db_xref="UniProtKB/Swiss-Prot:P42175" /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRW QYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGAS FSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKG GFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPM LSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEAR YKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEY AKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGT MGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLP IKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKE AVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGW AHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPI AASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQL QEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDS IRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFI HPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQP FGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSI ADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENI TNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPW RTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKW SVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHR IPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYY GPTGNQRDLNVVIRKLKEVDWLED*" /label="narG CDS" gene complement(3207860..3211546) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /label="narG gene" misc_feature complement(3211577..3211596) /Source="Nicolas_upshift_promotors" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3211601) /Source="Nicolas_upshifts" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3211603..3211732) /Source="Nicolas_S_feature" /locus_tag="new_3830002_3830131_c" /HighExp="Lbtran, M40t45, LBGtran, ferm, M0t45, nit, S0, Lbstat, LBGstat, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1448" CDS complement(3211742..3212218) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 11698370, 16428414, 22178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 11698370, 16428414, 22178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_391610.1" /db_xref="EnsemblGenomes-Gn:BSU37290" /db_xref="EnsemblGenomes-Tr:CAB15757" /db_xref="GOA:P46910" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018490" /db_xref="SubtiList:BG11345" /db_xref="UniProtKB/Swiss-Prot:P46910" /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSF LHSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSD ILILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS*" /label="arfM CDS" gene complement(3211742..3212218) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /label="arfM gene" downshifts complement(3211777) /Source="Nicolas_upshifts" /id="D1928" /incds=0 /nref=10 /ntot=39 /MaxReadThrough="5.03469" /MaxDrop="3.83412" /score="30.7487171" /energy="-10.5" /TU="U2936" /idTUdmin="U2936" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3212241..3212260) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-10" upshifts complement(3212253) /Source="Nicolas_upshifts" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="upshifts" promotor_-35 complement(3212275..3212278) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-35" upshifts 3212325 /Source="Nicolas_upshifts" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3212328..3212347 /Source="Nicolas_upshift_promotors" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3212362..3213081 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16428414, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391611.1" /db_xref="EnsemblGenomes-Gn:BSU37300" /db_xref="EnsemblGenomes-Tr:CAB15758" /db_xref="GOA:P46909" /db_xref="InterPro:IPR025576" /db_xref="SubtiList:BG11344" /db_xref="UniProtKB/Swiss-Prot:P46909" /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYL AVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMY FARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVK SVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTI GILEIVNACFFLAVMCLFITR*" /label="ywiC CDS" gene 3212362..3213081 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /label="ywiC gene" downshifts 3213065 /Source="Nicolas_upshifts" /id="D1929" /incds=0 /nref=14 /ntot=34 /MaxReadThrough="2.00369" /MaxDrop="5.63285" /score="-3.54009378" /energy="-5.8" /TU="NA" /idTUdmin="U2937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3213113..3213829) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 16796679, 21068385, 23046954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 16796679, 21068385, 23046954; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of anaerobic metabolism (FNR/CAP family)" /protein_id="NP_391612.1" /db_xref="EnsemblGenomes-Gn:BSU37310" /db_xref="EnsemblGenomes-Tr:CAB15759" /db_xref="GOA:P46908" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR012318" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018335" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11343" /db_xref="UniProtKB/Swiss-Prot:P46908" /translation="MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDA EELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEV LVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSN SYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKR DYLRCEIECENCPLEICNID*" /label="fnr CDS" gene complement(3213113..3213829) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /label="fnr gene" downshifts complement(3213115) /Source="Nicolas_upshifts" /id="D1930" /incds=0 /nref=116 /ntot=238 /MaxReadThrough="3.06242" /MaxDrop="8.21489" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-84" /isTUend="FALSE" /label="downshifts" downshifts complement(3213185) /Source="Nicolas_upshifts" /id="D1931" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.51297" /MaxDrop="3.71248" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" misc_feature complement(3213855..3213874) /Source="Nicolas_upshift_promotors" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3213867) /Source="Nicolas_upshifts" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3213928..3215115) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 15849754, 16796679, 16850406, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 15849754, 16796679, 16850406, 26786044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite extrusion permease" /protein_id="NP_391613.2" /db_xref="EnsemblGenomes-Gn:BSU37320" /db_xref="EnsemblGenomes-Tr:CAB15760" /db_xref="GOA:P46907" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11342" /db_xref="UniProtKB/Swiss-Prot:P46907" /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEI SLVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGG FFLGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKS TVQMYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAF VAFTIYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFA GLTLSGIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAM GGLGGFFPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQ SIN*" /label="narK CDS" gene complement(3213928..3215115) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /label="narK gene" misc_feature complement(3215145..3215164) /Source="Nicolas_upshift_promotors" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3215163) /Source="Nicolas_upshifts" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3215251..3216921) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /EC_number="6.1.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8289305, 9862121" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8289305, 9862121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginyl-tRNA synthetase" /protein_id="NP_391614.1" /db_xref="EnsemblGenomes-Gn:BSU37330" /db_xref="EnsemblGenomes-Tr:CAB15761" /db_xref="GOA:P46906" /db_xref="InterPro:IPR001278" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR005148" /db_xref="InterPro:IPR008909" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR035684" /db_xref="InterPro:IPR036695" /db_xref="SubtiList:BG11341" /db_xref="UniProtKB/Swiss-Prot:P46906" /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHG DYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTK LIPSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAG YDVSREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEY GDRFVNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKAL EALREKGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDK LINVWGADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVT MRDLIEEVGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQ GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASA LHSFYNAEKVIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM*" /label="argS CDS" gene complement(3215251..3216921) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /label="argS gene" downshifts complement(3215253) /Source="Nicolas_upshifts" /id="D1932" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="1.71727" /MaxDrop="6.56513" /score="23.3947976" /energy="-12.5" /TU="NA" /idTUdmin="U2941" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3216918..3217346) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_391615.1" /db_xref="EnsemblGenomes-Gn:BSU37340" /db_xref="EnsemblGenomes-Tr:CAB15762" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015231" /db_xref="PDB:1R0U" /db_xref="SubtiList:BG14161" /db_xref="UniProtKB/Swiss-Prot:O07624" /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYY EEHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKS IQSDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA*" /label="ywiB CDS" gene complement(3216918..3217346) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /label="ywiB gene" misc_feature 3217414..3217428 /Source="Nicolas_upshift_promotors" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3217414..3217433) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3217421 /Source="Nicolas_upshifts" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3217430) /Source="Nicolas_upshifts" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3217450..3217453) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3217485..3217504) /Source="Nicolas_upshift_promotors" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3217497) /Source="Nicolas_upshifts" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="upshifts" SCAR join(3217526,3217533) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs09" N_region 3217527..3217532 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs09" S_feature <3217533..3220011 /Source="Nicolas_S_feature" /locus_tag="new_3842996_3845478" /HighExp="Lbstat, nit, ferm, BI, M0t90, S2, M40t90, BT, M0t45, GM 150" /AntisenseName="ywhL" /AntisenseCor="7.7827453562424306E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1450" CDS complement(3217534..3218910) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12073041" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391624.1" /db_xref="EnsemblGenomes-Gn:BSU37440" /db_xref="EnsemblGenomes-Tr:CAB15771" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12464" /db_xref="UniProtKB/Swiss-Prot:P71004" /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEA SAAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGD GAVSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSP DPQSYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLV SVIDNKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPG ALDFALDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYV LNGELWPKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNL YVVNTARQRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVG AGPSAIAM*" /label="ywhL CDS" gene complement(3217534..3218910) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /label="ywhL gene" CDS complement(3218949..3220304) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12073041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073041; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DNA helicase PcrA" /protein_id="NP_391625.1" /db_xref="EnsemblGenomes-Gn:BSU37450" /db_xref="EnsemblGenomes-Tr:CAB15772" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12463" /db_xref="UniProtKB/Swiss-Prot:P71003" /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFV VDPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRN QYGQGDGAVSVIHNAEIDQVVYYSDESDDCPDISDITIENLVVVPPFYGSPLSVTGTI VLVPEPEPVYAFTANPNDQSVSVIDTNTDTVVTTIALPYNPAGIEITPDKSAVFVLHP NNNVISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRS IPVEGYDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAY VLEQEFFFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPN GAGVIGNVPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAIT I*" /label="ywhK CDS" gene complement(3218949..3220304) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /label="ywhK gene" promotor_-10 complement(3220340..3220359) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3220358) /Source="Nicolas_upshifts" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3220372..3220381) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3220484..3220503 /Source="Nicolas_upshift_promotors" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3220485 /Source="Nicolas_upshifts" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3220530) /Source="Nicolas_upshifts" /id="D1937" /incds=0 /nref=7 /ntot=59 /MaxReadThrough="2.35357" /MaxDrop="4.85842" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=1867 /isTUend="FALSE" /label="downshifts" CDS 3220534..3221679 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase anti-activator of ComA" /protein_id="NP_391626.1" /db_xref="EnsemblGenomes-Gn:BSU37460" /db_xref="EnsemblGenomes-Tr:CAB15773" /db_xref="GOA:P71002" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3ULQ" /db_xref="PDB:4I9C" /db_xref="PDB:4I9E" /db_xref="SubtiList:BG11968" /db_xref="UniProtKB/Swiss-Prot:P71002" /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQME EDQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYY FNFFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFS MDYARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQP QLMGRTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLG KIDKAHEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYA DLEDFAIDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV*" /label="rapF CDS" gene 3220534..3221679 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /label="rapF gene" promotor_-35 3221538..3221542 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3221559..3221578 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3221566 /Source="Nicolas_upshifts" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3221649) /Source="Nicolas_upshifts" /id="D1938" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="1.70728" /MaxDrop="2.74755" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 3221663..3221782 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapF" /protein_id="NP_391627.1" /db_xref="EnsemblGenomes-Gn:BSU37470" /db_xref="EnsemblGenomes-Tr:CAB15774" /db_xref="GOA:P71001" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11960" /db_xref="UniProtKB/Swiss-Prot:P71001" /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI*" /label="phrF CDS" gene 3221663..3221782 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /label="phrF gene" downshifts 3221767 /Source="Nicolas_upshifts" /id="D1939" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="5.48985" /MaxDrop="6.14096" /score="19.6493244" /energy="-9.9" /TU="U2946" /idTUdmin="U2947" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" S_feature 3221812..3221880 /Source="Nicolas_S_feature" /locus_tag="new_3847279_3847347" /HighExp="S2, S3, S4, S5, S6, S1, BT, S7, S8, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.921" /TUlongSig="NA" /TUlongPSig="NA" /label="S1451" CDS 3221881..3222354 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA editing enzyme" /protein_id="NP_391628.1" /db_xref="EnsemblGenomes-Gn:BSU37480" /db_xref="EnsemblGenomes-Tr:CAB15775" /db_xref="GOA:P71000" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12462" /db_xref="UniProtKB/Swiss-Prot:P71000" /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIA KSLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPF GLAHDPEVYLDVSLKRFQTVFPACGSRNSAIELTPKELSEFSFSKVWIDVCKDWE*" /label="ywhH CDS" gene 3221881..3222354 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /label="ywhH gene" downshifts 3222343 /Source="Nicolas_upshifts" /id="D1940" /incds=0 /nref=30 /ntot=156 /MaxReadThrough="2.85314" /MaxDrop="4.40065" /score="-6.80415499" /energy="-11.3" /TU="NA" /idTUdmin="U2946" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3222386..3223258) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /EC_number="3.5.3.11" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9723923, 10931887, 24678831, 28807600, 28291380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10931887, 24678831, 28807600, 28291380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="agmatinase" /protein_id="NP_391629.1" /db_xref="EnsemblGenomes-Gn:BSU37490" /db_xref="EnsemblGenomes-Tr:CAB15776" /db_xref="GOA:P70999" /db_xref="InterPro:IPR005925" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG12461" /db_xref="UniProtKB/Swiss-Prot:P70999" /translation="MRFDEAYSGKVFIASRPEWEEADAILYGMPMDWTVSYRPGSRFG PSRIREVSIGLEEYSPYLDRDLADLNFFDAGDIPLPFGNPQRSLDMIEEYVDSILEKG KFPMGMGGEHLVSWPVIKAMYKKYPDLAIIHFDAHTDLRVDYEGEPLSHSTPIRKAAE LIGPHNVYSFGIRSGMKEEFEWAKENGMHISKFEVLEPLKEVLPKLAGRPVYVTIDID VLDPAHAPGTGTVDAGGITSKELLASVHEIARSEVNVKGADLVEVAPVYDHSEQTANT ASKIIREMLLGFVK*" /label="speB CDS" gene complement(3222386..3223258) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /label="speB gene" downshifts complement(3222397) /Source="Nicolas_upshifts" /id="D1941" /incds=0 /nref=49 /ntot=171 /MaxReadThrough="2.5482" /MaxDrop="5.46925" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3222463) /Source="Nicolas_upshifts" /id="D1942" /incds=1 /nref=8 /ntot=50 /MaxReadThrough="5.83631" /MaxDrop="3.87062" /score="29.5788849" /energy="-11.3" /TU="U2948" /idTUdmin="U2948" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(3223319..3224149) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /EC_number="2.5.1.16" /function="16.3: Control" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9723923, 26735940, 28546427, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 26735940, 28546427, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermidine synthase; polyamine metabolism" /protein_id="NP_391630.1" /db_xref="EnsemblGenomes-Gn:BSU37500" /db_xref="EnsemblGenomes-Tr:CAB15777" /db_xref="GOA:P70998" /db_xref="InterPro:IPR001045" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030373" /db_xref="InterPro:IPR030374" /db_xref="InterPro:IPR035246" /db_xref="InterPro:IPR037163" /db_xref="PDB:1IY9" /db_xref="SubtiList:BG12460" /db_xref="UniProtKB/Swiss-Prot:P70998" /translation="MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGN MLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKK ATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEP VGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYT ANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK *" /label="speE CDS" gene complement(3223319..3224149) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /label="speE gene" S_feature complement(3224150..3224245) /Source="Nicolas_S_feature" /locus_tag="new_3849617_3849712_c" /HighExp="Paraq, G180, Oxctl, H2O2, LBGexp, G150, G135, C30, dia15, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1452" promotor_-10 complement(3224233..3224252) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3224244) /Source="Nicolas_upshifts" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3224265..3224272) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3224290..3224295 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3224311..3224329 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3224313 /Source="Nicolas_upshifts" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="upshifts" CDS 3224351..3226426 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10767540, 11567005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10767540, 11567005; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation specific penicillin-binding protein 2D" /protein_id="NP_391631.2" /db_xref="EnsemblGenomes-Gn:BSU37510" /db_xref="EnsemblGenomes-Tr:CAB15778" /db_xref="GOA:P70997" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG12459" /db_xref="UniProtKB/Swiss-Prot:P70997" /translation="MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQ GAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHH GFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQ NYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYS PYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDN AMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDP RTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETE FQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFG ITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPN QHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWM IGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTG VYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKW WDKWLGRHH*" /label="pbpG CDS" gene 3224351..3226426 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /label="pbpG gene" downshifts complement(3226479) /Source="Nicolas_upshifts" /id="D1943" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="1.43573" /MaxDrop="3.61075" /score="-7.59753556" /energy="-10.7" /TU="NA" /idTUdmin="U2951" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(3226603..3226718) /Source="Nicolas_S_feature" /locus_tag="new_3852070_3852185_c" /HighExp="Sw, C90, BI, dia5, dia15, Diami, LBGexp, M0t45, Lbexp, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1453" downshifts complement(3226646) /Source="Nicolas_upshifts" /id="D1944" /incds=0 /nref=198 /ntot=248 /MaxReadThrough="3.25498" /MaxDrop="6.4287" /score="-7.59753556" /energy="-10.7" /TU="U2951,U2952" /idTUdmin="U2952" /TUdmin="-156" /isTUend="FALSE" /label="downshifts" CDS complement(3226719..3227237) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391632.1" /db_xref="EnsemblGenomes-Gn:BSU37520" /db_xref="EnsemblGenomes-Tr:CAB15779" /db_xref="InterPro:IPR014852" /db_xref="SubtiList:BG12458" /db_xref="UniProtKB/Swiss-Prot:P70996" /translation="MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEE KEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACE MTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSS DELKTSLLPENN*" /label="ywhD CDS" gene complement(3226719..3227237) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /label="ywhD gene" CDS complement(3227251..3227910) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /EC_number="3.4.24.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase; integral membrane protein" /protein_id="NP_391633.1" /db_xref="EnsemblGenomes-Gn:BSU37530" /db_xref="EnsemblGenomes-Tr:CAB15780" /db_xref="GOA:P70995" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG12457" /db_xref="UniProtKB/Swiss-Prot:P70995" /translation="MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKK QGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLI LAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRII EDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPL L*" /label="ywhC CDS" gene complement(3227251..3227910) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /label="ywhC gene" promotor_-35 3227933..3227936 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3227946..3227965) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3227951..3227970 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3227954 /Source="Nicolas_upshifts" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3227964) /Source="Nicolas_upshifts" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3227966..3228249) /Source="Nicolas_S_feature" /locus_tag="new_3853433_3853716_c" /HighExp="Diami, dia5, dia15, C90, Etha, Sw, H2O2, G135, M40t45, Lbtran" /AntisenseName="ywhB" /AntisenseCor="0.10541372702249199" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1454" promotor_-35 complement(3227980..3227987) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3228019..3228207 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /EC_number="5.3.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12051677, 14624569, 14730980, 15301547, 17902707" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12051677, 14624569, 14730980, 15301547, 17902707; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxymuconate tautomerase (promiscuous)" /protein_id="NP_391634.1" /db_xref="EnsemblGenomes-Gn:BSU37540" /db_xref="EnsemblGenomes-Tr:CAB15781" /db_xref="GOA:P70994" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="InterPro:IPR018191" /db_xref="PDB:2OP8" /db_xref="PDB:2OPA" /db_xref="SubtiList:BG12456" /db_xref="UniProtKB/Swiss-Prot:P70994" /translation="MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIE EMRKDHYAVAGKRLSDME*" /label="hmtB CDS" gene 3228019..3228207 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /label="hmtB gene" downshifts 3228196 /Source="Nicolas_upshifts" /id="D1945" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="1.74275" /MaxDrop="4.93207" /score="4.21502693" /energy="-10.5" /TU="NA" /idTUdmin="U2950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3228250..3228669) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391635.1" /db_xref="EnsemblGenomes-Gn:BSU37550" /db_xref="EnsemblGenomes-Tr:CAB15782" /db_xref="GOA:P70993" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12455" /db_xref="UniProtKB/Swiss-Prot:P70993" /translation="MDHDKLEANLLDHALTKYLKSTKQLDEATVPKHVNNVRGFILRI IYRHGSCTIKDILKEVTLSPSATTTALNHLEQEGFIERSRNNNDRRTVWITLSESGRG AAEQMIENRQQLIDGMFERLTAEEKKTFLAIIAKLAQ*" /label="ywhA CDS" gene complement(3228250..3228669) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /label="ywhA gene" promotor_-10 complement(3228719..3228738) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3228730) /Source="Nicolas_upshifts" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3228753..3228760) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3228789..3230705) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9353933, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9353933, 15831787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_391636.2" /db_xref="EnsemblGenomes-Gn:BSU37560" /db_xref="EnsemblGenomes-Tr:CAB15783" /db_xref="GOA:P18256" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10421" /db_xref="UniProtKB/Swiss-Prot:P18256" /translation="MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVN GKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVIL DGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKL EILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQ RVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVR NELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPM NCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVRE DQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELG LSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRP VVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQA GIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQT FKDKLVKQVENRGM*" /label="thrZ CDS" gene complement(3228789..3230705) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /label="thrZ gene" promotor_-10 complement(3229983..3230001) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3229988) /Source="Nicolas_upshifts" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3230018..3230022) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3230736) /Source="Nicolas_upshifts" /id="D1946" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.2774" /MaxDrop="3.56231" /score="36.3785359" /energy="-19.5" /TU="U2955" /idTUdmin="U2953" /TUdmin="-968" /isTUend="FALSE" /label="downshifts" misc_RNA complement(3230759..3230980) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /product="T-box" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTB RNA" gene complement(3230759..3230980) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /label="tboTB gene" misc_RNA complement(3231012..3231233) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTA RNA" gene complement(3231012..3231233) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /label="tboTA gene" S_feature complement(3231265..3231527) /Source="Nicolas_S_feature" /locus_tag="new_3856732_3856994_c" /HighExp="S8, S7, S6, S5, BT, Sw, B36, B60, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.61719100000000005" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1455" downshifts 3231276 /Source="Nicolas_upshifts" /id="D1947" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="0.92811" /MaxDrop="3.85666" /score="1.17237511" /energy="-8.3" /TU="NA" /idTUdmin="U2950" /TUdmin=3080 /isTUend="FALSE" /label="downshifts" downshifts complement(3231308) /Source="Nicolas_upshifts" /id="D1948" /incds=0 /nref=52 /ntot=200 /MaxReadThrough="6.68945" /MaxDrop="6.6969" /score="36.414771" /energy="-17.3" /TU="U2955" /idTUdmin="U2953" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3231315..3231470) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514011.1" /translation="MLFTVSREGRTAEIFLTQGKQLTAFEPYQGKQVSDTVMLRYSIF KPIIMCN*" /label="hypothetical protein CDS" gene complement(3231315..3231470) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /label="gene" promotor_-35 3231477..3231480 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3231489..3231502 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3231496 /Source="Nicolas_upshifts" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3231504..3231523) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3231527) /Source="Nicolas_upshifts" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3231537..3231543) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3231550..3232950) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11104814, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11104814, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="toxic compound efflux transporter (may export homoserine)" /protein_id="NP_391637.1" /db_xref="EnsemblGenomes-Gn:BSU37570" /db_xref="EnsemblGenomes-Tr:CAB15784" /db_xref="GOA:Q00538" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10420" /db_xref="UniProtKB/Swiss-Prot:Q00538" /translation="MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMK NTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAAS INGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPF IGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFL SYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQF IGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEA GQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAG QRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLV WLFLAAHNGTAASEKM*" /label="mmr CDS" gene complement(3231550..3232950) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /label="mmr gene" CDS complement(3232950..3233420) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885456; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391638.1" /db_xref="EnsemblGenomes-Gn:BSU37580" /db_xref="EnsemblGenomes-Tr:CAB15785" /db_xref="GOA:P71047" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12454" /db_xref="UniProtKB/Swiss-Prot:P71047" /translation="MKMKSGMEQAVSVLLLLSRLPVQASLTSEAISQRLRVSPSYLKK LMRTLVQAGLAESLPGTKGGFTLTKPLADITLYDVYQAVEGRGSMYQGKGLLQSVFEG ESHCVLETVMAEIEDKWSNLMREESLQHVMDRVGELYDLEKIDDWVIKQVKGQL*" /label="ywgB CDS" gene complement(3232950..3233420) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /label="ywgB gene" downshifts complement(3233376) /Source="Nicolas_upshifts" /id="D1949" /incds=0 /nref=11 /ntot=145 /MaxReadThrough="2.78131" /MaxDrop="4.29115" /score="17.3758052" /energy="-11.2" /TU="NA" /idTUdmin="U2956" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3233532..3234032) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391639.1" /db_xref="EnsemblGenomes-Gn:BSU37590" /db_xref="EnsemblGenomes-Tr:CAB15786" /db_xref="SubtiList:BG12453" /db_xref="UniProtKB/Swiss-Prot:P71046" /translation="MLKEHAKLMKVFSDSGEIIGRKKLQKMIYIAKKMQFPFYEKYDF HFYGPYSEELTLQIEELCNLGFLHEVKEKKGGYFQYRYSLTETGSAFLDHADLDMPDM KGYIDSVNSRSSRFLELVSTILYFDGLEDEEKKEKVFTIKSKQKYTNEEYDEALQYIE ELKQIC*" /label="ywgA CDS" gene complement(3233532..3234032) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /label="ywgA gene" downshifts complement(3233535) /Source="Nicolas_upshifts" /id="D1950" /incds=0 /nref=9 /ntot=105 /MaxReadThrough="4.00805" /MaxDrop="6.12059" /score="17.3758052" /energy="-11.2" /TU="U2956,U2957" /idTUdmin="U2957" /TUdmin="-137" /isTUend="FALSE" /label="downshifts" CDS complement(3234068..3235369) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent nucleotide (pyro)phosphohydrolase" /protein_id="NP_391640.1" /db_xref="EnsemblGenomes-Gn:BSU37600" /db_xref="EnsemblGenomes-Tr:CAB15787" /db_xref="GOA:P39651" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG10639" /db_xref="UniProtKB/Swiss-Prot:P39651" /translation="MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRI KQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHD LGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNK QVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAV EDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGK LTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFE LTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAI VESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT*" /label="ywfO CDS" gene complement(3234068..3235369) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /label="ywfO gene" promotor_-10 complement(3235393..3235412) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3235407) /Source="Nicolas_upshifts" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3235409..3235530) /Source="Nicolas_S_feature" /locus_tag="new_3860876_3860997_c" /HighExp="G180, Paraq, Oxctl, G135, H2O2, G150, C30, LBGstat, LBGexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1456" promotor_-35 complement(3235428..3235430) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3235531..3235755) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391641.1" /db_xref="EnsemblGenomes-Gn:BSU37610" /db_xref="EnsemblGenomes-Tr:CAB15788" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR020880" /db_xref="SubtiList:BG14164" /db_xref="UniProtKB/Swiss-Prot:O32280" /translation="MANEFRVCDDCQATNIKTLLPRLKEVDPDAKVEVGCQSYCGPGR KKSFAFVNNRPLSAPTEDELIDKVKKKIKK*" /label="ywzC CDS" gene complement(3235531..3235755) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /label="ywzC gene" S_feature complement(3235756..3235840) /Source="Nicolas_S_feature" /locus_tag="new_3861223_3861307_c" /HighExp="G180, Paraq, H2O2, G135, LBGexp, dia15, G150, Lbexp, Heat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1457" promotor_-10 complement(3235829..3235848) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3235839) /Source="Nicolas_upshifts" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3235863..3235866) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3235906..3235912 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3235927..3235938 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3235928 /Source="Nicolas_upshifts" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="upshifts" CDS 3235970..3236746 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10629188, 16497325, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629188, 16497325, 22829778; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="prespore-specific transcription regulatory gene" /protein_id="NP_391642.1" /db_xref="EnsemblGenomes-Gn:BSU37620" /db_xref="EnsemblGenomes-Tr:CAB15789" /db_xref="GOA:P39650" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017877" /db_xref="SubtiList:BG10638" /db_xref="UniProtKB/Swiss-Prot:P39650" /translation="MTKQRQDAWSEENDLLLAETVLRHVREGSTQLNAFEEVGDKLNR TSAACGFRWNAVVRHQYEKALQLAKKQRKQRMRALGNGQPAKKRLLYQPPAVDPEIIQ ETAAEEPVKTETPSVENEQPLMSGEHMPFVDESFKEELASLSHLLSPQTPAAAPEMTM NDVIRFLQNYEGNHEQSSALKMENERLKKENQELQNKTEQLEAEVQKLEKDQKTIQED YETLVKIMNRARKLVLFEEDEHASPSFKMDRNGNLEKLAE*" /label="psrF CDS" gene 3235970..3236746 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /label="psrF gene" downshifts 3236732 /Source="Nicolas_upshifts" /id="D1951" /incds=0 /nref=14 /ntot=78 /MaxReadThrough="4.08166" /MaxDrop="4.36214" /score="-5.88286948" /energy="-14.4" /TU="U2958" /idTUdmin="U2958" /TUdmin="-3036" /isTUend="FALSE" /label="downshifts" promotor_-35 3236834..3236841 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3236856..3236875 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3236860..3241086 /Source="Nicolas_S_feature" /locus_tag="new_3862327_3866553" /HighExp="T1.30H, T2.0H, T1.0H, T2.30H, T0.30H, T3.0H, T3.30H, T4.0H, T5.0H, T0.0H" /AntisenseName="pta" /AntisenseCor="-0.61235087907102503" /AntisenseRegPval="-28.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.836" /TUlongSig="NA" /TUlongPSig="NA" /label="S1458" upshifts 3236860 /Source="Nicolas_upshifts" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3236890..3237780) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative toxic excess metabolite exporter" /protein_id="NP_391643.1" /db_xref="EnsemblGenomes-Gn:BSU37630" /db_xref="EnsemblGenomes-Tr:CAB15790" /db_xref="GOA:P39649" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004779" /db_xref="SubtiList:BG10637" /db_xref="UniProtKB/Swiss-Prot:P39649" /translation="MKGNIYSLFVLIAAFFWGTTGTVQALAPESATPLAFGAFRLLIG GSAMLLAVWISRELHVKNWAWPLVFLAAVCMACYQPLFFTAVKETGIAVGTVIAIGSA PIIAGTLEWAVLKKRPRNSWWIATVLALAGCWLLFSDSSNVRIDVAGVLMALGAGASF AGYTLISKAMMKTQPPRATSAVVFMISAILLTPLLWQLDISWILTPRGLGTSLYIGLI ATCAAYFLFAKGLTGVPASAAVTLSLAEPLTASLLGVFFIGEMLSPSSWLGIALMMLG LLVISAAPRKQKTAEAAHMS*" /label="ywfM CDS" gene complement(3236890..3237780) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /label="ywfM gene" promotor_no_box complement(3237780..3237880) /Source="Nicolas_upshift_promotors" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3237820) /Source="Nicolas_upshifts" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3237948..3238793) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /function="4: Biosynthesis of cofactors, prosthetic groups, and carriers" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidotransferase of the octanoyl moiety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase" /protein_id="NP_391644.1" /db_xref="EnsemblGenomes-Gn:BSU37640" /db_xref="EnsemblGenomes-Tr:CAB15791" /db_xref="GOA:P39648" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024897" /db_xref="SubtiList:BG10636" /db_xref="UniProtKB/Swiss-Prot:P39648" /translation="MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGK GVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGV LNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSING KKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRP ETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERN AKVFG*" /label="lipL CDS" gene complement(3237948..3238793) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /label="lipL gene" downshifts complement(3238111) /Source="Nicolas_upshifts" /id="D1952" /incds=1 /nref=4 /ntot=180 /MaxReadThrough="3.21908" /MaxDrop="3.30122" /score="31.9003746" /energy="-18.6" /TU="U2961" /idTUdmin="U2961" /TUdmin="-27" /isTUend="FALSE" /label="downshifts" CDS complement(3238842..3239741) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sulfur assimilation CysL, activatescysJI expression" /protein_id="NP_391645.1" /db_xref="EnsemblGenomes-Gn:BSU37650" /db_xref="EnsemblGenomes-Tr:CAB15792" /db_xref="GOA:P39647" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10635" /db_xref="UniProtKB/Swiss-Prot:P39647" /translation="MYYDVLKTFIAVVEEKNFTKAAEKLMISQPSVSLHIKNLEKEFQ TALLNRSPKHFTTTPTGDILYQRAKQMVFLYEQAKAEIYAHHHYVKGELKIAASFTIG EYILPPLLAQLQKLYPELNLDVMIGNTEEVSERVRMLQADIGLIEGHTNENELEIEPF MEDEMCIAAPNQHPLAGRKEISISDLQNEAWVTREKGSGTREYLDHVLSSNGLRPKSM FTISSNQGVKEAVINGMGLSVLSRSVLRKDLIHREISILHINNFSLKRKLSYIHSPLM ENTKNKEIFITMLKSNYQSQLLK*" /label="cysL CDS" gene complement(3238842..3239741) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /label="cysL gene" promotor_-10 complement(3239784..3239803) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3239787) /Source="Nicolas_upshifts" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3239817..3239824) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3239888) /Source="Nicolas_upshifts" /id="D1953" /incds=0 /nref=222 /ntot=251 /MaxReadThrough="1.96406" /MaxDrop="7.24606" /score="32.3178773" /energy="-17.3" /TU="NA" /idTUdmin="U2962" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3239888..3240859) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /EC_number="2.3.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphotransacetylase" /protein_id="NP_391646.1" /db_xref="EnsemblGenomes-Gn:BSU37660" /db_xref="EnsemblGenomes-Tr:CAB15793" /db_xref="GOA:P39646" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR004614" /db_xref="InterPro:IPR012147" /db_xref="PDB:1TD9" /db_xref="PDB:1XCO" /db_xref="SubtiList:BG10634" /db_xref="UniProtKB/Swiss-Prot:P39646" /translation="MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNP IVIGNENEIQAKAKELNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKAL LDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEE QYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVA DAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGY KIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL*" /label="pta CDS" gene complement(3239888..3240859) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /label="pta gene" promotor_-10 complement(3240894..3240913) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3240919) /Source="Nicolas_upshifts" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3240929..3240933) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3241007..3241018) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3241010) /Source="Nicolas_upshifts" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3241032..3241038) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3241081..3241100 /Source="Nicolas_upshift_promotors" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3241088 /Source="Nicolas_upshifts" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="upshifts" CDS 3241129..3241893 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /EC_number="4.1.-.-" /function="4.3: Heme, porphyrin, and cobalamin" /experiment="publication(s) with functional evidences, PMID:15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-coproporphyrin (coproheme) decarboxylase" /protein_id="NP_391647.3" /db_xref="EnsemblGenomes-Gn:BSU37670" /db_xref="EnsemblGenomes-Tr:CAB15794" /db_xref="GOA:P39645" /db_xref="InterPro:IPR010644" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR031332" /db_xref="SubtiList:BG10633" /db_xref="UniProtKB/Swiss-Prot:P39645" /translation="MSEQQMTNEAAKTLDGWYALHDFRTMDWASWKLLSSDERQSIIH EFTGLLEKWGVAQKEGKGSQTLYSIVGQKADFMLMILRPTMEELNQIELEFNKSRLAE FTIPAYSYVSVVELSNYLASGDGDPYENPHVRARLYPELPESKYVCFYPMDKRRSGND NWYMLSMEERRNLMRSHGLIGRSYAGKVKQIITGSVGFDDYEWGVTLFSDDVLQFKKL VYEMRFDEVSARYGEFGSFFVGNHLSLDTLPQFLYV*" /label="hemQ CDS" gene 3241129..3241893 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /label="hemQ gene" downshifts 3241880 /Source="Nicolas_upshifts" /id="D1954" /incds=0 /nref=155 /ntot=246 /MaxReadThrough="5.49286" /MaxDrop="6.26609" /score="19.319449" /energy="-14.5" /TU="U2964" /idTUdmin="U2959" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(3241900,3241907) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs11" N_region 3241901..3241906 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs11" S_feature <3241907..3241959 /Source="Nicolas_S_feature" /locus_tag="new_3873771_3874382" /HighExp="Etha, Salt, Gly, Heat, C30, LPhT, HiTm, C90, S8, M/G" /AntisenseName="bacA" /AntisenseCor="9.8443047207874598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1459" CDS complement(3241909..3243147) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15609023, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391655.1" /db_xref="EnsemblGenomes-Gn:BSU37750" /db_xref="EnsemblGenomes-Tr:CAB15802" /db_xref="GOA:P39637" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10625" /db_xref="UniProtKB/Swiss-Prot:P39637" /translation="MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDL AKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICAL AQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVP LGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDAL KVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVIT GKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTI LSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLS VFAYKKYGKLEQKADQSLSQ*" /label="ywfA CDS" gene complement(3241909..3243147) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /label="ywfA gene" promotor_-10 complement(3243189..3243208) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3243201) /Source="Nicolas_upshifts" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3243220..3243227) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3243357..3244769) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7540694, 8113162, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="basic aminoacid permease" /protein_id="NP_391656.1" /db_xref="EnsemblGenomes-Gn:BSU37760" /db_xref="EnsemblGenomes-Tr:CAB15803" /db_xref="GOA:P39636" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10624" /db_xref="UniProtKB/Swiss-Prot:P39636" /translation="MQNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQAGPL GAIAAYIIGGFLMYLVMLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWA NTVGLELTSAGILMQRWLPSVPIWIWCLVFGIVIFLINALSVRSFAEMEFWFSSIKVA AIILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQG TELVGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVA VLDQIGIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKGV PMNALLITLGISGCSLLTSVMAAETVYLWCISISGMVTVVAWMSICASQFFFRRRFLA EGGNVNDLEFRTPLYPLVPILGFCLYGCVLISLIFIPDQRIGLYCGVPIIIFCYAYYH LSIKKRINHETIEKKQTEAQ*" /label="rocC CDS" gene complement(3243357..3244769) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /label="rocC gene" downshifts complement(3243364) /Source="Nicolas_upshifts" /id="D1957" /incds=0 /nref=16 /ntot=112 /MaxReadThrough="1.06691" /MaxDrop="5.69562" /score="41.626335" /energy="-15.9" /TU="NA" /idTUdmin="U2971" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3244769..3246469) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8113162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase involved in arginine and ornithine utilization" /protein_id="NP_391657.1" /db_xref="EnsemblGenomes-Gn:BSU37770" /db_xref="EnsemblGenomes-Tr:CAB15804" /db_xref="GOA:P39635" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG10623" /db_xref="UniProtKB/Swiss-Prot:P39635" /translation="MQYTKISHMNPAERVEALTASLVSLSSVNGTVGEGTKADFIKEV ITSYPYFQENPSHVWEQAIPNDPYKRKNIFAFIKGHGESRNTVIYHAHLDTVGIEDFG PLKDIAFDCEKLAEYFSRYEFDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFS ENLETLPGNVLFMANPDEESQHSGILASISELNRLKKEKQLHYLAAINTDFITPLYDG DQTRYIYTGAAGKLLPCFYIYGREVHVGDTLAGIDPNFISSEITSRLHNNIHLAEKVE GELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLLIEVTEEACRET EQKLSDYYEEYVKRANLPKKHLSWGIQVYSLEQYLEKLRNRGIDPEQCIEQTFKANEH LELRMRCFQAIEELQKLDPDQGAKVILFYAPPYLPHNYLKEDSARDQLLQHVIKEAAD KTAESTGETFVFKKFFPYLADGSFLSLHETDGEIDSFIRNFPGWNMIGTIPFKDIRKL NIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQTTVHLLQSYRMTITAKEPKGEG *" /label="rocB CDS" gene complement(3244769..3246469) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /label="rocB gene" misc_feature complement(3245438..3245454) /Source="Nicolas_upshift_promotors" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3245450) /Source="Nicolas_upshifts" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3246543..3248090) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11418582, 12634342, 8113162, 9383188, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-1-pyrroline-5 carboxylate dehydrogenase" /protein_id="NP_391658.1" /db_xref="EnsemblGenomes-Gn:BSU37780" /db_xref="EnsemblGenomes-Tr:CAB15805" /db_xref="GOA:P39634" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10622" /db_xref="UniProtKB/Swiss-Prot:P39634" /translation="MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGE KIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILF KAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSR AGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFV EVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPG QKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYD EVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDD SKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLT KNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQA KTTSEAF*" /label="rocA CDS" gene complement(3246543..3248090) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /label="rocA gene" downshifts complement(3246550) /Source="Nicolas_upshifts" /id="D1958" /incds=0 /nref=4 /ntot=50 /MaxReadThrough="5.60027" /MaxDrop="3.5628" /score="41.626335" /energy="-15.9" /TU="U2971,U2972" /idTUdmin="U2973" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3248134) /Source="Nicolas_upshifts" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3248136..3248316) /Source="Nicolas_S_feature" /locus_tag="new_3880559_3880739_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1460" misc_feature complement(3248137..3248155) /Source="Nicolas_upshift_promotors" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3248317..3249591) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate dehydrogenase" /protein_id="NP_391659.2" /db_xref="EnsemblGenomes-Gn:BSU37790" /db_xref="EnsemblGenomes-Tr:CAB15806" /db_xref="GOA:P39633" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K92" /db_xref="SubtiList:BG10621" /db_xref="UniProtKB/Swiss-Prot:P39633" /translation="MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKE PQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMT LKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTN SQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIK LQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFG MVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDAT KILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIY QTAATHKVDMRLAAYMTGIRKSAEASRFRGWV*" /label="rocG CDS" gene complement(3248317..3249591) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /label="rocG gene" S_feature complement(3249592..3249674) /Source="Nicolas_S_feature" /locus_tag="new_3882015_3882097_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.83780600000000005" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1461" upshifts complement(3249674) /Source="Nicolas_upshifts" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3249687..3249705) /Source="Nicolas_upshift_promotors" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3249767) /Source="Nicolas_upshifts" /id="D1959" /incds=0 /nref=9 /ntot=144 /MaxReadThrough="4.82066" /MaxDrop="4.13762" /score="22.6949864" /energy="-11.4" /TU="U2973" /idTUdmin="U2977" /TUdmin=369 /isTUend="FALSE" /label="downshifts" CDS complement(3249768..3250232) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /experiment="publication(s) with functional evidences, PMID:15187182, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 28751732; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity" /protein_id="NP_391660.1" /db_xref="EnsemblGenomes-Gn:BSU37800" /db_xref="EnsemblGenomes-Tr:CAB15807" /db_xref="GOA:P39632" /db_xref="InterPro:IPR034650" /db_xref="PDB:5MKD" /db_xref="SubtiList:BG10620" /db_xref="UniProtKB/Swiss-Prot:P39632" /translation="MLKRTSFVSSLFISSAVLLSILLPSGQAHAQSASIEAKTVNSTK EWTISDIEVTYKPNAVLSLGAVEFQFPDGFHATTRDSVNGRTLKETQILNDGKTVRLP LTLDLLGASEFDLVMVRKTLPRAGTYTIKGDVVNGLGIGSFYAETQLVIDPR*" /label="bslB CDS" gene complement(3249768..3250232) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /label="bslB gene" S_feature complement(3250233..3250343) /Source="Nicolas_S_feature" /locus_tag="new_3882656_3882766_c" /HighExp="C90, S1, S0, MG 150, M9-tran, LPhT, BI, GM 150, Lbtran, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1462" promotor_-10 complement(3250325..3250344) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-10" upshifts complement(3250343) /Source="Nicolas_upshifts" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="upshifts" promotor_-35 complement(3250359..3250366) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-35" downshifts complement(3250554) /Source="Nicolas_upshifts" /id="D1960" /incds=0 /nref=32 /ntot=80 /MaxReadThrough="3.01999" /MaxDrop="4.92444" /score="6.35246869" /energy="-8.4" /TU="U2977" /idTUdmin="U2977" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3250556..3251011) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /EC_number="5.1.3.13" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25239894; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat)" /protein_id="YP_054595.1" /db_xref="EnsemblGenomes-Gn:BSU37810" /db_xref="EnsemblGenomes-Tr:CAE01469" /db_xref="GOA:Q7WY56" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG14195" /db_xref="UniProtKB/Swiss-Prot:Q7WY56" /translation="MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYP GVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKG VAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR*" /label="spsL CDS" gene complement(3250556..3251011) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /label="spsL gene" misc_feature 3250646..3250665 /Source="Nicolas_upshift_promotors" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3250654 /Source="Nicolas_upshifts" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3251004..3251855) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /EC_number="1.1.1.133" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-dehydrorhamnose reductase" /protein_id="NP_391661.3" /db_xref="EnsemblGenomes-Gn:BSU37820" /db_xref="EnsemblGenomes-Tr:CAB15808" /db_xref="GOA:P39631" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR029903" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10619" /db_xref="UniProtKB/Swiss-Prot:P39631" /translation="MTKVLVTGAGGQLGLELCRQLKQAGYEVIALTKKMMNIADQRSV RHSFGHYQPDIVVNSAAFTSVDQCEKELDKAYLINGIGAYYTALESTRIGAQYVHIST DYVFNGKGTQPYREDDPLDPKTIYGKSKRLGEELIRLTTKDSTIIRTSWVYGHGGSNF VETMLKLAETKQELRVVSDQIGSPTYTKDLAEAVIKLFSHPPGIYHVSNSGICSWYEF ATAIMEESGLETAILSVTTEEYGNKTPRPAYSVLSHRAIEEAGIRPRHWREALREYLQ ERSSACD*" /label="spsK CDS" gene complement(3251004..3251855) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /label="spsK gene" CDS complement(3251869..3252816) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /EC_number="4.2.1.46" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dTDP-glucose 4,6-dehydratase" /protein_id="NP_391662.1" /db_xref="EnsemblGenomes-Gn:BSU37830" /db_xref="EnsemblGenomes-Tr:CAB15809" /db_xref="GOA:P39630" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10618" /db_xref="UniProtKB/Swiss-Prot:P39630" /translation="MAKSYLITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEE MEKLKQNSRFRFVKGDISVQEDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNV MGTYRLAEAVLKGKAKKLIHISTDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDL LVLSYVKTHKLPAIITRCSNNYGPYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWL FAEDHCRAIKLILEKGTDGEVYNIGGGNERTNKELASVILKHLGCEELFAHVEDRKGH DRRYAINASKLKNELGWRQEVTFEEGIARTIQWYTDNDR*" /label="spsJ CDS" gene complement(3251869..3252816) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /label="spsJ gene" CDS complement(3252816..3253556) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /EC_number="2.7.7.24" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase" /protein_id="NP_391663.1" /db_xref="EnsemblGenomes-Gn:BSU37840" /db_xref="EnsemblGenomes-Tr:CAB15810" /db_xref="GOA:P39629" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10617" /db_xref="UniProtKB/Swiss-Prot:P39629" /translation="MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEA GIKDILLISQKEHMPQFYKLLGNGEELGVTITYQVQPAASGISDGLSYAKRFTKKESF ILLLGDNIFEDSLKPYTERFEQQGKGAKVLLKEVDDPERFGIAEIDEKNKRIRSIIEK PEQPPTNLCVTGIYMYDAEVFSYIEQISPSKRGELEITDVNNLYIENSQLTYDVLSGW WVDAGTHESLYLASQLVHQALRKGQDEK*" /label="spsI CDS" gene complement(3252816..3253556) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /label="spsI gene" promotor_-35 3253574..3253579 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3253580 /Source="Nicolas_upshifts" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3253581..3254600) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391664.1" /db_xref="EnsemblGenomes-Gn:BSU37850" /db_xref="EnsemblGenomes-Tr:CAB15811" /db_xref="GOA:P39627" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10615" /db_xref="UniProtKB/Swiss-Prot:P39627" /translation="MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEA FLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVL FEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLK KDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK PQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFAD QGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDL YEQEI*" /label="spsG CDS" gene complement(3253581..3254600) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /label="spsG gene" promotor_-10 3253594..3253612 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3254464..3254473 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3254486..3254501 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3254497 /Source="Nicolas_upshifts" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3254603..3255325) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391665.2" /db_xref="EnsemblGenomes-Gn:BSU37860" /db_xref="EnsemblGenomes-Tr:CAB15812" /db_xref="InterPro:IPR003329" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10614" /db_xref="UniProtKB/Swiss-Prot:P39626" /translation="MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSAFY QKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRL TGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQ YQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDV SASELITLLNRNPDAATEREAD*" /label="spsF CDS" gene complement(3254603..3255325) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /label="spsF gene" CDS complement(3255318..3256439) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /EC_number="2.5.-.-" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12597896, 15774001; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoenolpyruvate-sugar pyruvyltransferase" /protein_id="NP_391666.1" /db_xref="EnsemblGenomes-Gn:BSU37870" /db_xref="EnsemblGenomes-Tr:CAB15813" /db_xref="GOA:P39625" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR036732" /db_xref="PDB:1VLI" /db_xref="SubtiList:BG10613" /db_xref="UniProtKB/Swiss-Prot:P39625" /translation="MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEA GADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQ VIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISD VHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHP TEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGIT KPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQG LHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE*" /label="spsE CDS" gene complement(3255318..3256439) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /label="spsE gene" CDS complement(3256439..3257308) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative TDP-glycosamine N-acetyltransferase" /protein_id="NP_391667.1" /db_xref="EnsemblGenomes-Gn:BSU37880" /db_xref="EnsemblGenomes-Tr:CAB15814" /db_xref="GOA:P39624" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10612" /db_xref="UniProtKB/Swiss-Prot:P39624" /translation="MYTVKENVSKEAIEEFLQSRKLTLDVPYQFSLGLFENSRLQGVL LYEDSLWESKVLQKKVMNVKLLAANSTGQLKRLFEAFYTVRQMDETDFIFVRVPAEDI GAAHVIQQQPSSYFVGSLLKLAMPPSFYDKTPPFFELGPPEPGDTEAICELARDSFTK SRYFQDPHLSRDAANEIFQEWTRNNLNGRAAVNIVAKHNGEVIGYLQGLSRDDECILD LMAVKPGFEGKRIAFHLLANLIEQPETQKHRTVTAGTQLHNVRAIRLYERMGFTAEQS YYYYHIWPGKEAK*" /label="spsD CDS" gene complement(3256439..3257308) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /label="spsD gene" CDS complement(3257309..3258478) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /EC_number="2.6.1.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14602648; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glutamine-dependent sugar transaminase" /protein_id="NP_391668.1" /db_xref="EnsemblGenomes-Gn:BSU37890" /db_xref="EnsemblGenomes-Tr:CAB15815" /db_xref="GOA:P39623" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10611" /db_xref="UniProtKB/Swiss-Prot:P39623" /translation="MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEK EFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPV FADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAA HAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSK AAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAF QQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVH IHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD*" /label="spsC CDS" gene complement(3257309..3258478) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /label="spsC gene" CDS complement(3258499..3259923) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22611084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP glycosyl/glycerophosphate transferase or transport" /protein_id="NP_391669.2" /db_xref="EnsemblGenomes-Gn:BSU37900" /db_xref="EnsemblGenomes-Tr:CAB15816" /db_xref="GOA:P39622" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10610" /db_xref="UniProtKB/Swiss-Prot:P39622" /translation="MSAYLSNYWVLYRKYVELFDKLRYKGIPLGLISNFYQYISPELR VMMEEEPELFGSVDQHIDEGQIQPFFEERIQNIVKTNDEPVKGKVILHFDYLRFSNEN YYQFDPEKTAVLARWSLPHYCDLPVISKREIADSCQKGDSKQYLETACSLLAPYDDHP AFGDQAFRDRLFKDIPLFIEAIDTVDALFEQEKISAVIVGTAEDIYSRVLALMCQRKG AVSICLQHGALMGDEAFIPVFTTYQAVFGAYEAEWFIRKGCKPEQILVTGHPRFDQIF NRTPMDMSIFYRKLAFQPTKKIVLIATQPFSEDFYSGVLQGLSDQKQLQIIIKPHPWE IGKNKLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTVGLEAMLFQKPVLI GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANYPVA ESTNALFAELKAKTGVDYRREDTE*" /label="spsB CDS" gene complement(3258499..3259923) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /label="spsB gene" CDS complement(3259928..3260698) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10350455, 11042447, 11733986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10350455, 11042447, 11733986; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat dTDP-glycosyltransferase" /protein_id="NP_391670.1" /db_xref="EnsemblGenomes-Gn:BSU37910" /db_xref="EnsemblGenomes-Tr:CAB15817" /db_xref="GOA:P39621" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PDB:1H7L" /db_xref="PDB:1H7Q" /db_xref="PDB:1QG8" /db_xref="PDB:1QGQ" /db_xref="PDB:1QGS" /db_xref="SubtiList:BG10609" /db_xref="UniProtKB/Swiss-Prot:P39621" /translation="MPKVSVIMTSYNKSDYVAKSISSILSQTFSDFELFIMDDNSNEE TLNVIRPFLNDNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIY MPDRLLKMVRELDTHPEKAVIYSASKTYHLNENRDIVKETVRPAAQVTWNAPCAIDHC SVMHRYSVLEKVKEKFGSYWDESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITD QSIHFQLFELEKNEFVRNLPPQRNCRELRESLKKLGMG*" /label="spsA CDS" gene complement(3259928..3260698) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /label="spsA gene" promotor_-10 complement(3260733..3260752) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3260747) /Source="Nicolas_upshifts" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3260766..3260775) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3260866..3260871 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3260887..3260905 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3260889..3261017 /Source="Nicolas_S_feature" /locus_tag="new_3893312_3893440" /HighExp="S5, S4, S3, S7, B36, S8, S6, B60, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1463" upshifts 3260889 /Source="Nicolas_upshifts" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="upshifts" CDS 3261018..3261563 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12644503, 15317760, 16936016, 16936016, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12644503, 15317760, 16936016, 16936016, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391671.1" /db_xref="EnsemblGenomes-Gn:BSU37920" /db_xref="EnsemblGenomes-Tr:CAB15818" /db_xref="GOA:P39620" /db_xref="InterPro:IPR014099" /db_xref="SubtiList:BG10608" /db_xref="UniProtKB/Swiss-Prot:P39620" /translation="MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQ PMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENI LRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY ITFDEEIAYTYPYSMASYSPR*" /label="gerQ CDS" gene 3261018..3261563 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /label="gerQ gene" downshifts 3261549 /Source="Nicolas_upshifts" /id="D1961" /incds=0 /nref=60 /ntot=77 /MaxReadThrough="1.98659" /MaxDrop="7.96105" /score="16.9179802" /energy="-11.7" /TU="NA" /idTUdmin="U2978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3261607..3261978) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15919996, 21810204; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391672.2" /db_xref="EnsemblGenomes-Gn:BSU37930" /db_xref="EnsemblGenomes-Tr:CAB15819" /db_xref="GOA:P39619" /db_xref="InterPro:IPR006696" /db_xref="SubtiList:BG10607" /db_xref="UniProtKB/Swiss-Prot:P39619" /translation="MKVFIILGAINALLAVGLGAFGAHGLEGKIPDKYLQVWHTGVQY HMYHALGLFVVAFLADKLSGIGSVTTAGWLMFAGIVLFSGSLYILSVTQISILGAITP LGGVAFIISWIMIVVAAVKYL*" /label="ywdK CDS" gene complement(3261607..3261978) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /label="ywdK gene" downshifts complement(3261625) /Source="Nicolas_upshifts" /id="D1962" /incds=0 /nref=134 /ntot=227 /MaxReadThrough="3.65585" /MaxDrop="4.84049" /score="15.105437" /energy="-11.7" /TU="NA" /idTUdmin="U2979" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3262040..3263362) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine/pyrimidine permease" /protein_id="NP_391673.2" /db_xref="EnsemblGenomes-Gn:BSU37940" /db_xref="EnsemblGenomes-Tr:CAB15820" /db_xref="GOA:P39618" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="SubtiList:BG10606" /db_xref="UniProtKB/Swiss-Prot:P39618" /translation="MKLVLGALQWTAFIIAAAIVVPVAVAQSFHLDHSDSARLIQSTF FVLGIAAVIQCLKGHRLPINESPAGLWWGVYTIYAGLTGTVFATYGDTLRGLQGALLV SAVCFFLLSVFKVIDRLAKLFTPVVTGVYLLLLVMQLSQPIIKGILGIGYRQDGVDGL VFGLALVVIAAAFIMTNSNIMFFKQYSILLALFGGWVLFAAAGAAKPIEMPDRLFQLP SLFPFGTPLFNSGLIITSIFITILLIVNMLASMKVVDIAMKKFSKQPDGKHHERHAGF AASFSHLLSGLTGAIAPVPISGAAGFIETTKMPSKKPFMLGSILVIVISVIPFFMNTF ASLPSPVGFAVNFVVFSAMGGLAFAEFDSYEKEESKRVRSIIGISLLTGVGIMFVPET ALKGLHPVFISLLSNGLVLGTLAAIAADQFQLWRRRKSDNLVSTENKH*" /label="ywdJ CDS" gene complement(3262040..3263362) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /label="ywdJ gene" CDS complement(3263382..3263699) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391674.3" /db_xref="EnsemblGenomes-Gn:BSU37950" /db_xref="EnsemblGenomes-Tr:CAB15821" /db_xref="InterPro:IPR035218" /db_xref="SubtiList:BG10605" /db_xref="UniProtKB/Swiss-Prot:P39617" /translation="MNIHISALIQKMEEELKKAKTAERDEELKRYVAVVRSLCDVVLD QPENASAPRIQPSVTPSPAAPPSTDQLMMEKMMGSAGLNKYRKQEKEKQEEDGNGESL FDF*" /label="ywdI CDS" gene complement(3263382..3263699) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /label="ywdI gene" promotor_-10 complement(3263728..3263747) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3263739) /Source="Nicolas_upshifts" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3263761..3263767) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3263802..3263809 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3263825..3263844 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3263828 /Source="Nicolas_upshifts" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="upshifts" CDS 3263867..3265237 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391675.2" /db_xref="EnsemblGenomes-Gn:BSU37960" /db_xref="EnsemblGenomes-Tr:CAB15822" /db_xref="GOA:P39616" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10604" /db_xref="UniProtKB/Swiss-Prot:P39616" /translation="MNSIPSIISKHKAYFAAGHTRPLESRLNILRKLKQAVRTHEADL IAALYQDLHKSEQEAYSTEIGIVLEEISFVMKRLRKWSKPKRVKTPLTHLGSKSIIIP EPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISSVFPT DYVAMAEGGPDVSTALLQQPFDYIFFTGSVAVGKIVMEAAAKQLIPVTLELGGKSPCI VHKDADIQLAAKRIVFGKFTNAGQTCIAPDYLFVHEDIKTKLTEEMKRAIREFYGPQP ERNPQYGKIVSERHYQRLLSFLNDGIPLTGGQSDPNHHKIAPTILEQVRDDSPVMQEE IFGPILPLFTYRNIGEVIEKVQSRPKPLALYLFTTNKEIERAVLGNLSFGGGCVNDTL MHVATPYLPFGGVGESGIGSYHGFDSFNTFTHKKSVVKQTNRFDFAFRYPSSKNGLRM IRKILK*" /label="ywdH CDS" gene 3263867..3265237 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /label="ywdH gene" CDS complement(3265262..3265939) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /EC_number="3.2.2.27" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1902430, 9776748, 10080896, 21542855, 22056936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1902430, 9776748, 10080896, 21542855, 22056936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil-DNA glycosylase" /protein_id="NP_391676.1" /db_xref="EnsemblGenomes-Gn:BSU37970" /db_xref="EnsemblGenomes-Tr:CAB15823" /db_xref="GOA:P39615" /db_xref="InterPro:IPR002043" /db_xref="InterPro:IPR005122" /db_xref="InterPro:IPR018085" /db_xref="InterPro:IPR036895" /db_xref="PDB:3ZOQ" /db_xref="PDB:3ZOR" /db_xref="SubtiList:BG10603" /db_xref="UniProtKB/Swiss-Prot:P39615" /translation="MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRD IFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIG CSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPI DWCIKDL*" /label="ung CDS" gene complement(3265262..3265939) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /label="ung gene" downshifts complement(3265276) /Source="Nicolas_upshifts" /id="D1963" /incds=0 /nref=66 /ntot=224 /MaxReadThrough="2.25259" /MaxDrop="4.72154" /score="26.8023311" /energy="-9.1" /TU="NA" /idTUdmin="U2982" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3265766..3265785) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3265782) /Source="Nicolas_upshifts" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3265801..3265806) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3265953..3266759) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /EC_number="2.4.-.-" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9334165; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391677.1" /db_xref="EnsemblGenomes-Gn:BSU37980" /db_xref="EnsemblGenomes-Tr:CAB15824" /db_xref="GOA:P39614" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10602" /db_xref="UniProtKB/Swiss-Prot:P39614" /translation="MKISIVIVTYNRIPALCELLESISRQTLMPYEIIIVNDAGESVV PVKALYPELPIAVINLEKNSGHVAARNAGVKEASGDCIMLCDDDDFFTPGHIEKMAKE IETADFVHSDAEIVSFEEKNGTRYPVSRKLFAYTADYEDMRVFSTYVPSGSMYRRFLH DEIGYFDADVHNYWDWDFYLRAAKDYRVKRVPCASVIYAFSDAGDNQSADLGAKRKQY LDRLSEKHGLGELPTKNFAVLLEEPEMKRREAKSEMVWDGEPVYSRLHRS*" /label="ywdF CDS" gene complement(3265953..3266759) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /label="ywdF gene" promotor_-10 complement(3266252..3266270) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3266266) /Source="Nicolas_upshifts" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3266285..3266291) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3266788..3266807) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3266794) /Source="Nicolas_upshifts" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3266823..3266830) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3266849..3267382) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391678.1" /db_xref="EnsemblGenomes-Gn:BSU37990" /db_xref="EnsemblGenomes-Tr:CAB15825" /db_xref="GOA:P39613" /db_xref="SubtiList:BG10601" /db_xref="UniProtKB/Swiss-Prot:P39613" /translation="MRISSCLYGFVAHGAVFLFTGGCMLLAMAASLPFVFLLDRLPDV VFTAGAILTLLCSYAYVWFWAVRFAYNQKMRLFEVQLGSFVLLALMISLFLLDGSSMK DIMMNWDDAGCAFVPPAFTFLCLSYALVLLPVYQSKLWRLILPNGVRMKDIFHVFGDL MLIMVLLIGATLLFLSL*" /label="ywdE CDS" gene complement(3266849..3267382) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /label="ywdE gene" CDS complement(3267430..3268065) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391679.2" /db_xref="EnsemblGenomes-Gn:BSU38000" /db_xref="EnsemblGenomes-Tr:CAB15826" /db_xref="GOA:P39612" /db_xref="SubtiList:BG10600" /db_xref="UniProtKB/Swiss-Prot:P39612" /translation="MDKETYVSEIKSGLKGLPEGEAMIEEIESHIEHHLFRSFQEGKS EEEAMQTLLQAFGTPTDIVSSFKKIQPVTFRAFLMFHLFCNSALFAVGIAITIMHVWL ESPFVQAVWKGISVSVWLILAAYMIYWVLIGYQGVKEFGKRGEKLVLHTILISMVPNV IFMLVFLFNVIPAALFQSLLTPWFVGTCAFATLLFPLFGRMGCYIGRRQLV*" /label="ywdD CDS" gene complement(3267430..3268065) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /label="ywdD gene" CDS complement(3268058..3268396) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator, PadR family" /protein_id="YP_003097793.1" /db_xref="EnsemblGenomes-Gn:BSU38018" /db_xref="EnsemblGenomes-Tr:CAX52706" /db_xref="GOA:C0H3S6" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S6" /translation="MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMK EGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMD RILKWSGQNG*" /label="ywzG CDS" gene complement(3268058..3268396) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /label="ywzG gene" promotor_-10 complement(3268418..3268437) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3268429) /Source="Nicolas_upshifts" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3268452..3268459) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3268480..3268483 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3268498..3268517 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3268498 /Source="Nicolas_upshifts" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="upshifts" CDS 3268540..3269355 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /EC_number="2.7.1.35" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14973012, 17012797" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14973012, 17012797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyridoxine, pyridoxal, and pyridoxamine kinase" /protein_id="NP_391681.1" /db_xref="EnsemblGenomes-Gn:BSU38020" /db_xref="EnsemblGenomes-Tr:CAB15828" /db_xref="GOA:P39610" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="PDB:2I5B" /db_xref="SubtiList:BG10598" /db_xref="UniProtKB/Swiss-Prot:P39610" /translation="MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAM DPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLK NVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDM IEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTF SAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS*" /label="pdxK CDS" gene 3268540..3269355 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /label="pdxK gene" downshifts 3269334 /Source="Nicolas_upshifts" /id="D1964" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="2.56759" /MaxDrop="5.39956" /score="22.0760698" /energy="-18.1" /TU="NA" /idTUdmin="U2985" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3269410) /Source="Nicolas_upshifts" /id="D1965" /incds=0 /nref=20 /ntot=111 /MaxReadThrough="0.56945" /MaxDrop="6.81686" /score="39.7901804" /energy="-16.8" /TU="NA" /idTUdmin="U2987" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3269445..3269693) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391682.1" /db_xref="EnsemblGenomes-Gn:BSU38030" /db_xref="EnsemblGenomes-Tr:CAB15829" /db_xref="SubtiList:BG10597" /db_xref="UniProtKB/Swiss-Prot:P39609" /translation="MNIHEQKITPECLEKAANQVEDKREEYKDVLLQLKKMLGGTTPH SETAEILTRAYEQMKEYALFVQSIETFLRKSANNLKIK*" /label="ywdA CDS" gene complement(3269445..3269693) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /label="ywdA gene" downshifts complement(3269465) /Source="Nicolas_upshifts" /id="D1966" /incds=0 /nref=6 /ntot=123 /MaxReadThrough="6.75845" /MaxDrop="3.89221" /score="22.6408081" /energy="-10.8" /TU="U2987,U2988" /idTUdmin="U2986" /TUdmin=11 /isTUend="TRUE" /label="downshifts" upshifts complement(3269711) /Source="Nicolas_upshifts" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3269713..3269786) /Source="Nicolas_S_feature" /locus_tag="new_3902136_3902209_c" /HighExp="G150, Mt0, Diami, Lbexp, dia0, dia5, T0.30H, Oxctl, Etha, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.536, 0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1464" misc_feature complement(3269721..3269727) /Source="Nicolas_upshift_promotors" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3269787..3271226) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /EC_number="3.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3100393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sucrose-6-phosphate hydrolase" /protein_id="NP_391683.2" /db_xref="EnsemblGenomes-Gn:BSU38040" /db_xref="EnsemblGenomes-Tr:CAB15830" /db_xref="GOA:P07819" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR006232" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG10596" /db_xref="UniProtKB/Swiss-Prot:P07819" /translation="MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDP NGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCY SGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHF RDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYM WECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELD QGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKL IQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTA TFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSA RYFPFPGNHEVTASATGKSEMNVGIWTLM*" /label="sacA CDS" gene complement(3269787..3271226) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /label="sacA gene" CDS complement(3271223..3272608) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /EC_number="2.7.1.211" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1577686, 3122206, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 3122206, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) sucrose-specificenzyme IIBC component" /protein_id="NP_391684.3" /db_xref="EnsemblGenomes-Gn:BSU38050" /db_xref="EnsemblGenomes-Tr:CAB15831" /db_xref="GOA:P05306" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10595" /db_xref="UniProtKB/Swiss-Prot:P05306" /translation="MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQ VEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPA ARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFL PILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQ GTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGS GITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWS MANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMI GGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFV MKINEDEERKK*" /label="sacP CDS" gene complement(3271223..3272608) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /label="sacP gene" misc_feature complement(3272627..3272636) /Source="Nicolas_upshift_promotors" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3272641) /Source="Nicolas_upshifts" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3272643..3272707) /Source="Nicolas_S_feature" /locus_tag="new_3905066_3905130_c" /HighExp="Diami, G150, dia5, Mt0, M9-stat, Lbtran, Gly, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1465" promotor_-10 complement(3272686..3272703) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3272707) /Source="Nicolas_upshifts" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3272719..3272726) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3272749..3272768) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3272767) /Source="Nicolas_upshifts" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3272782..3272789) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3272848..3272851 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3272858 /Source="Nicolas_upshifts" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3272866..3272885 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3272910..3273680 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16207915, 16428414, 16850406, 18691156; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite transporter" /protein_id="NP_391685.1" /db_xref="EnsemblGenomes-Gn:BSU38060" /db_xref="EnsemblGenomes-Tr:CAB15832" /db_xref="GOA:P39608" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG10594" /db_xref="UniProtKB/Swiss-Prot:P39608" /translation="METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITA ASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWR DTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRG MLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHP DTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ*" /label="nirC CDS" gene 3272910..3273680 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /label="nirC gene" S_feature 3273681..3274748 /Source="Nicolas_S_feature" /locus_tag="new_3906104_3907171" /HighExp="S0, ferm, M0t45, Lbexp, Mal, dia0, M/G, UNK1, M40t45, BI" /AntisenseName="sacT" /AntisenseCor="-0.34218080984654098" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1466" CDS complement(3273719..3274549) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1577686, 2163394, 8535520, 8702561, 19202299, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 2163394, 8535520, 8702561, 19202299, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator of sacAP expression" /protein_id="NP_391686.1" /db_xref="EnsemblGenomes-Gn:BSU38070" /db_xref="EnsemblGenomes-Tr:CAB15833" /db_xref="GOA:P26212" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="SubtiList:BG10593" /db_xref="UniProtKB/Swiss-Prot:P26212" /translation="MKIYKVLNNNAALIKEDDQEKIVMGPGIAFQKKKNDLIPMNKVE KIFVVRDENEKFKQILQTLPEEHIEIAEDIISYAEGELAAPLSDHIHIALSDHLSFAI ERIQNGLLVQNKLLHEIKALYKKEYEIGLWAIGHVKETLGVSLPEDEAGYIALHIHTA KMDAESMYSALKHTTMIKEMIEKIKQYFNRKVDENSISYQRLVTHLRYAVSRLESNEA LHRMDEEMLYFIQKKYSFAYQCALELAEFLKNEYQLHLPESEAGYITLHVQRLQDLSE *" /label="sacT CDS" gene complement(3273719..3274549) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /label="sacT gene" downshifts complement(3273720) /Source="Nicolas_upshifts" /id="D1967" /incds=0 /nref=49 /ntot=139 /MaxReadThrough="3.34691" /MaxDrop="4.9787" /score="11.2756812" /energy="-8.1" /TU="U2992" /idTUdmin="U2991" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3274575..3274594) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3274581) /Source="Nicolas_upshifts" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3274589..3274891) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391687.2" /db_xref="EnsemblGenomes-Gn:BSU38080" /db_xref="EnsemblGenomes-Tr:CAB15834" /db_xref="SubtiList:BG10592" /db_xref="UniProtKB/Swiss-Prot:P39607" /translation="MKRLLVSLRVWMVFLMNWVTPDRKTAAAAVYSAQRTYQRKAAVQ AAGLVSFYEWRMAVNEEEKQKAKAAALYKRRCLQAFKESPKQERAGPHLYMAVKRR*" /label="ywcI CDS" gene complement(3274589..3274891) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /label="ywcI gene" promotor_-35 complement(3274609..3274616) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3274892..3275030) /Source="Nicolas_S_feature" /locus_tag="new_3907315_3907453_c" /HighExp="T5.0H, M9-stat, S2, S4, T4.0H, S3, T3.30H, LoTm, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.823" /TUlongSig="NA" /TUlongPSig="NA" /label="S1467" misc_feature complement(3275015..3275034) /Source="Nicolas_upshift_promotors" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3275030) /Source="Nicolas_upshifts" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3275345..3275353 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3275364..3275382 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3275365 /Source="Nicolas_upshifts" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="upshifts" CDS 3275421..3275498 /gene="vpr" /old_locus_tag="BSU_38090" /created_by="User" /modified_by="User" /transl_table=11 /locus_tag="PG10_BSU_38090-3'_ext" /translation="MKKGISQQTPPAISDTIGAYLQNDA*" /label="PG10_BSU_38090-3'_ext" gene 3275421..3275498 /gene="vpr_3'-chimera" /old_locus_tag="BSU_38090" /created_by="User" /locus_tag="PG10_BSU_38090-3'_ext" /label="PG10_BSU_38090-3'_ext" SCAR 3275431..3275432 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_017" CDS complement(3275434..3276435) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913069, 15774866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391689.1" /db_xref="EnsemblGenomes-Gn:BSU38100" /db_xref="EnsemblGenomes-Tr:CAB15836" /db_xref="GOA:P39606" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10590" /db_xref="UniProtKB/Swiss-Prot:P39606" /translation="MVSLSILDQSPVSEGSNAETALQQTVALAQAAEDLGYKRFWVSE HHFSKRLAGSSPEVLISHIAAKTKRIRVGSGGVMLPHYSAYKVAENFRVLEGLTPGRI DLGLGRAPGGMPIASWALNDGGKRNADQYPQQIKELTMYLHDLADDKHRFPNLTAAPH ISTAPDVWLLGSSGESALLAAESGAGYMFAHFINGEGGEGTVRQYKRRFKPSVLGDTP RAAVAVFVLCADTEEKAEELGAVLDFTLLAGEQGIPLEGVPSYEAVRKNTYSPYEQRR IADNRNRMIVGTKEQVKERLLALSNAYETEEIMVVTITHHFEDKLRSYRLLQEAFAD* " /label="ywcH CDS" gene complement(3275434..3276435) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /label="ywcH gene" S_feature complement(3276436..3276597) /Source="Nicolas_S_feature" /locus_tag="new_3911304_3911465_c" /HighExp="Etha, Diami, dia15, LPhT, dia5, H2O2, B60, LBGstat, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1468" CDS complement(3276609..3277358) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /EC_number="1.5.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-containing NADPH-linked nitro/flavin reductase" /protein_id="NP_391690.1" /db_xref="EnsemblGenomes-Gn:BSU38110" /db_xref="EnsemblGenomes-Tr:CAB15837" /db_xref="GOA:P39605" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:3N2S" /db_xref="SubtiList:BG10589" /db_xref="UniProtKB/Swiss-Prot:P39605" /translation="MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQ AYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLE NTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFG LAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKRE ETWSDQILNFMKQKPRTYLNDYVKEKGFNKN*" /label="nfrAA CDS" gene complement(3276609..3277358) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /label="nfrAA gene" downshifts complement(3276642) /Source="Nicolas_upshifts" /id="D1969" /incds=0 /nref=11 /ntot=191 /MaxReadThrough="5.92216" /MaxDrop="3.39651" /score="17.7447455" /energy="-9.9" /TU="U2995" /idTUdmin="U2996" /TUdmin=770 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3277376..3277395) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3277393) /Source="Nicolas_upshifts" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3277410..3277413) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3277464..3278645) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9622350, 15612918, 15849754, 16850406, 28085152" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 15612918, 15849754, 16850406, 28085152; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycosyltransferase involved in extension of thelateral walls of the cell" /protein_id="NP_391691.1" /db_xref="EnsemblGenomes-Gn:BSU38120" /db_xref="EnsemblGenomes-Tr:CAB15838" /db_xref="GOA:P39604" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10588" /db_xref="UniProtKB/Swiss-Prot:P39604" /translation="MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTD WIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGA KSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPV GLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAK SVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPE STTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALI VIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFN S*" /label="rodA CDS" gene complement(3277464..3278645) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /label="rodA gene" downshifts complement(3277478) /Source="Nicolas_upshifts" /id="D1970" /incds=0 /nref=20 /ntot=124 /MaxReadThrough="3.38052" /MaxDrop="5.67563" /score="31.4805549" /energy="-13.3" /TU="U2996" /idTUdmin="U2996" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3278646..3278777) /Source="Nicolas_S_feature" /locus_tag="new_3913514_3913645_c" /HighExp="Heat, T0.30H, H2O2, T1.0H, Salt, Paraq, T1.30H, LBGstat, Oxctl, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1469" promotor_-10 complement(3278771..3278786) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-10" upshifts complement(3278777) /Source="Nicolas_upshifts" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="upshifts" promotor_-35 complement(3278798..3278807) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-35" promotor_-35 3279012..3279019 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3279030..3279140 /Source="Nicolas_S_feature" /locus_tag="new_3913898_3914008" /HighExp="M9-stat, T0.30H, T1.30H, T1.0H, T4.0H, T2.30H, T3.30H, T3.0H, T5.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1470" promotor_-10 3279030..3279049 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3279030 /Source="Nicolas_upshifts" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="upshifts" CDS 3279141..3279404 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16159778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159778; Product type f: factor" /codon_start=1 /transl_table=11 /product="holin-like protein required for proper spore morphogenesis and germination" /protein_id="NP_391692.1" /db_xref="EnsemblGenomes-Gn:BSU38130" /db_xref="EnsemblGenomes-Tr:CAB15839" /db_xref="GOA:P39603" /db_xref="InterPro:IPR020185" /db_xref="SubtiList:BG10587" /db_xref="UniProtKB/Swiss-Prot:P39603" /translation="MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFY ATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS*" /label="ywcE CDS" gene 3279141..3279404 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /label="ywcE gene" downshifts 3279294 /Source="Nicolas_upshifts" /id="D1971" /incds=1 /nref=1 /ntot=99 /MaxReadThrough="6.85004" /MaxDrop="2.5697" /score="27.9247684" /energy="-11.4" /TU="U2997" /idTUdmin="U2997" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3279410 /Source="Nicolas_upshifts" /id="D1972" /incds=0 /nref=7 /ntot=90 /MaxReadThrough="2.04756" /MaxDrop="6.52141" /score="27.9247684" /energy="-11.4" /TU="NA" /idTUdmin="U2997" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3279447..3279821) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit IV)" /protein_id="NP_391693.1" /db_xref="EnsemblGenomes-Gn:BSU38140" /db_xref="EnsemblGenomes-Tr:CAB15840" /db_xref="GOA:P34959" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014250" /db_xref="SubtiList:BG10586" /db_xref="UniProtKB/Swiss-Prot:P34959" /translation="MANKSAEHSHFPWKHIVGFILSIVLTLLALWVAVYTDLSSSAKL WIIFGFAFIQAALQLLMFMHMTESENGTIQVGNTLFGFFGAIVIVLGSIWIFAAHYHH GDHMDGNPPGGAEHSEHSGHNE*" /label="qoxD CDS" gene complement(3279447..3279821) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /label="qoxD gene" downshifts complement(3279458) /Source="Nicolas_upshifts" /id="D1973" /incds=0 /nref=222 /ntot=267 /MaxReadThrough="2.42368" /MaxDrop="9.0593" /score="21.3154492" /energy="-11.4" /TU="NA" /idTUdmin="U3000" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3279823..3280437) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit III)" /protein_id="NP_391694.1" /db_xref="EnsemblGenomes-Gn:BSU38150" /db_xref="EnsemblGenomes-Tr:CAB15841" /db_xref="GOA:P34958" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR014246" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10585" /db_xref="UniProtKB/Swiss-Prot:P34958" /translation="MEHAEHGNSNAPMEYQSETGRLNILGFWIFLGAEIVLFSTLFAT FFVLKNRTAGGVLPDELFEVNLVMIMTFLLLISSFTCGIAVHEMRRGSLKGVVIWTII TLLLGAGFVGCEINEFVHYVHEGAALSTSAFWSGFFVLLGTHGTHVTIGIFWITGILI QLKKRGLTPQTSSKIFISSLYWHFLDVVWIFIFTGVYLMGLGGL*" /label="qoxC CDS" gene complement(3279823..3280437) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /label="qoxC gene" CDS complement(3280451..3282400) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit I)" /protein_id="NP_391695.1" /db_xref="EnsemblGenomes-Gn:BSU38160" /db_xref="EnsemblGenomes-Tr:CAB15842" /db_xref="GOA:P34956" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014233" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10584" /db_xref="UniProtKB/Swiss-Prot:P34956" /translation="MKFKWDEFFVTGDPLILGAQVSIALSTIAIIFVLTYFKKWKWLW SEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTH GTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGG SPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTL MRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFW IWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTM GNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGV TGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGK WFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLI LCYNIYYSFRYSTREISGDSWGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKE EKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVL RSFEYDNGYYISVDEIKETERKISE*" /label="qoxB CDS" gene complement(3280451..3282400) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /label="qoxB gene" misc_feature 3281664..3281683 /Source="Nicolas_upshift_promotors" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3281670 /Source="Nicolas_upshifts" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3282094..3282194 /Source="Nicolas_upshift_promotors" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3282154 /Source="Nicolas_upshifts" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3282264 /Source="Nicolas_upshifts" /id="D1974" /incds=1 /nref=1 /ntot=73 /MaxReadThrough="3.07388" /MaxDrop="3.44223" /score="-7.14620582" /energy="-8.1" /TU="U2999" /idTUdmin="U2999" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" CDS complement(3282428..3283393) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 22720735, 26196462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit II)" /protein_id="NP_391696.2" /db_xref="EnsemblGenomes-Gn:BSU38170" /db_xref="EnsemblGenomes-Tr:CAB15843" /db_xref="GOA:P34957" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR006332" /db_xref="InterPro:IPR006333" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR034227" /db_xref="InterPro:IPR036257" /db_xref="SubtiList:BG10583" /db_xref="UniProtKB/Swiss-Prot:P34957" /translation="MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSD LILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPIL IVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIP VDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEH FADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVD HGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE*" /label="qoxA CDS" gene complement(3282428..3283393) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /label="qoxA gene" S_feature complement(3283394..3283462) /Source="Nicolas_S_feature" /locus_tag="new_3918262_3918330_c" /HighExp="M0t90, M40t90, Lbtran, Lbstat, M40t45, S2, nit, ferm, LBGstat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="0.626, 1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1471" promotor_-10 complement(3283449..3283468) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3283462) /Source="Nicolas_upshifts" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3283464..3283649) /Source="Nicolas_S_feature" /locus_tag="new_3918332_3918517_c" /HighExp="LBGstat, Heat, G150, G135, LBGtran, G180, BMM, Salt, LBGexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1472" promotor_-35 complement(3283481..3283485) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3283580..3283585 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3283601..3283619 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3283606 /Source="Nicolas_upshifts" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3283640..3283659) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3283649) /Source="Nicolas_upshifts" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3283651..3283760) /Source="Nicolas_S_feature" /locus_tag="new_3918519_3918628_c" /HighExp="Heat, Salt, LBGstat, BMM, Oxctl, H2O2, MG 15, UNK1, MG-0.1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1473" promotor_-35 complement(3283674..3283678) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3283716 /Source="Nicolas_upshifts" /id="D1975" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.69533" /MaxDrop="4.01393" /score="13.5410442" /energy="-16.4" /TU="U3001" /idTUdmin="U3001" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3283745..3283764) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3283760) /Source="Nicolas_upshifts" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3283780..3283784) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3283838..3283856) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3283843..3283849 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3283855) /Source="Nicolas_upshifts" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3283864..3283882 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3283867 /Source="Nicolas_upshifts" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3283872..3283877) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3283909..3284154 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391697.2" /db_xref="EnsemblGenomes-Gn:BSU38180" /db_xref="EnsemblGenomes-Tr:CAB15844" /db_xref="GOA:O32282" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG14162" /db_xref="UniProtKB/Swiss-Prot:O32282" /translation="MSFLISLIVAIIIGWLGSLFVKGDMPGGIIGSMIAGLIGAWIGH GLLGTWGPHLAGFAIIPAVIGAAIVVFLVSLLTRKRG*" /label="ywzA CDS" gene 3283909..3284154 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /label="ywzA gene" downshifts 3284136 /Source="Nicolas_upshifts" /id="D1976" /incds=0 /nref=125 /ntot=189 /MaxReadThrough="2.63086" /MaxDrop="7.72876" /score="13.5410442" /energy="-16.4" /TU="NA" /idTUdmin="U3005" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3284225..3285766) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /EC_number="2.7.7.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917, 11790749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917, 11790749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactose-1-phosphate uridyltransferase" /protein_id="NP_391698.2" /db_xref="EnsemblGenomes-Gn:BSU38190" /db_xref="EnsemblGenomes-Tr:CAB15845" /db_xref="GOA:P39575" /db_xref="InterPro:IPR000766" /db_xref="InterPro:IPR005849" /db_xref="InterPro:IPR005850" /db_xref="InterPro:IPR023425" /db_xref="SubtiList:BG10582" /db_xref="UniProtKB/Swiss-Prot:P39575" /translation="MSIIEHLEQLLEYGLERKLISIWDREYTRNRLYEALGITHPEPN SSTSIKQSQSLPDLLAPIYKWAAETGRMEADTDTYRDLLSAKLMGCFVPAPSEVIRKF EETKALYGPKQATKEFYQYSEDVYYIRTDRIAKNVHWTVPTEYGELEMTINLSKPEKD PKAIAAAKEQEQTNYPMCLLCKENVGFEGSVNHPARQNHRIIPVILEDEQWFLQFSPY VYYPEHCIVLKGEHEPMEISKKTFERLLSFLGQYPHYFIGSNADLPIVGGSILSHDHF QGGAHDFPMARAEAEDVYELNDYPGVSLGLVKWPMSVLRLQGDEPGHVAEAADHIFRT WQTYSDEKAGIAAYTGDTPHNTVTPIARRRGDLYELDIVLRNNRTDEEHPLGIFHPHQ EVHHIKKENIGLIEVMGLAILPGRLQEEMKETAAALCSADPKTALEQNPLTAKHSEWA LRTMEKRTITKENVDLVIKEELGHVFARILEHAGVFKQTAEGKQAFRRFIDQLGAKPV KSLNR*" /label="galT CDS" gene complement(3284225..3285766) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /label="galT gene" downshifts complement(3284254) /Source="Nicolas_upshifts" /id="D1977" /incds=0 /nref=190 /ntot=254 /MaxReadThrough="0.3431" /MaxDrop="6.63153" /score="21.0691542" /energy="-14.7" /TU="NA" /idTUdmin="U3006" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3285770..3286942) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /EC_number="2.7.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactokinase" /protein_id="NP_391699.1" /db_xref="EnsemblGenomes-Gn:BSU38200" /db_xref="EnsemblGenomes-Tr:CAB15846" /db_xref="GOA:P39574" /db_xref="InterPro:IPR000705" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR006206" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR019539" /db_xref="InterPro:IPR019741" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022963" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10581" /db_xref="UniProtKB/Swiss-Prot:P39574" /translation="MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFP CALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEF QQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQH AENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRT LADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVY ENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGS RMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE*" /label="galK CDS" gene complement(3285770..3286942) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /label="galK gene" promotor_-10 complement(3286960..3286978) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3286982) /Source="Nicolas_upshifts" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3286993..3286999) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3287023..3287406) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882654, 15849754, 16850406, 18192405; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall glycosylation protein" /protein_id="NP_391700.1" /db_xref="EnsemblGenomes-Gn:BSU38210" /db_xref="EnsemblGenomes-Tr:CAB15847" /db_xref="GOA:P39602" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG10580" /db_xref="UniProtKB/Swiss-Prot:P39602" /translation="MYIIMGVFTTIVNIASFYILVEIMNVDYKAATVAAWILSVLFAY ITNKLYVFQQKTHDLQSLLKELTAFFSVRVLSLGIDLGMMIILVGQFNTNETLAKILD NAVIVVVNYVASKWLVFKKTKEEGV*" /label="ywcD CDS" gene complement(3287023..3287406) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /label="ywcD gene" CDS complement(3287424..3288095) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of slrA (biofilm formation)" /protein_id="NP_391701.2" /db_xref="EnsemblGenomes-Gn:BSU38220" /db_xref="EnsemblGenomes-Tr:CAB15848" /db_xref="GOA:P39601" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10579" /db_xref="UniProtKB/Swiss-Prot:P39601" /translation="MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGY SKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELL YSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDAC IDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSE SEEHQ*" /label="slrC CDS" gene complement(3287424..3288095) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /label="slrC gene" promotor_-10 complement(3288117..3288136) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3288126) /Source="Nicolas_upshifts" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3288152..3288155) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3288236..3288239 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3288254..3288273 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3288263..3288450 /Source="Nicolas_S_feature" /locus_tag="new_3923131_3923318" /HighExp="T0.30H, T1.0H, Cold, T1.30H, HiOs, T-0.40H, T2.0H, T2.30H, T4.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1474" upshifts 3288263 /Source="Nicolas_upshifts" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="upshifts" CDS 3288451..3288609 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168, 26857544" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168, 26857544; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-repressor of SlrR" /protein_id="YP_003097794.1" /db_xref="EnsemblGenomes-Gn:BSU38229" /db_xref="EnsemblGenomes-Tr:CAX52707" /db_xref="GOA:P0C8M5" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="UniProtKB/Swiss-Prot:P0C8M5" /translation="MKTHVKKDLDKGWHMLIQEARSIGLGIHDVRQFLESETASRKKN HKKTVRQD*" /label="slrA CDS" gene 3288451..3288609 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /label="slrA gene" S_feature 3288610..3288994 /Source="Nicolas_S_feature" /locus_tag="new_3923478_3923862" /HighExp="T0.30H, Cold, T1.30H, T2.0H, T1.0H, HiOs, T2.30H, T3.0H, LBGstat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1475" promotor_-35 3288975..3288980 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3288996..3289014 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3288996 /Source="Nicolas_upshifts" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="upshifts" CDS 3289052..3289360 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of acetate transporter as a volatile signal for biofilm formation" /protein_id="NP_391702.1" /db_xref="EnsemblGenomes-Gn:BSU38230" /db_xref="EnsemblGenomes-Tr:CAB15849" /db_xref="GOA:P39600" /db_xref="InterPro:IPR007436" /db_xref="SubtiList:BG10578" /db_xref="UniProtKB/Swiss-Prot:P39600" /translation="MYKADYKQIAATPSFQAFLKQKRAFIVPSAIFFFVFYFSLPVLT SYFTFLNAPAIGAVSWAWLFAIAQFAMTWILSTVYSRRAAHFDKYVSALKEDLKGEQT *" /label="vbfB CDS" gene 3289052..3289360 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /label="vbfB gene" downshifts complement(3289138) /Source="Nicolas_upshifts" /id="D1978" /incds=1 /nref=3 /ntot=15 /MaxReadThrough="0.42282" /MaxDrop="5.4957" /score="10.1452497" /energy="-8.3" /TU="NA" /idTUdmin="U3010" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3289142..3289242) /Source="Nicolas_upshift_promotors" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3289182) /Source="Nicolas_upshifts" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3289357..3290898 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="acetate Na+-dependent symporter subunit involvedin volatile signal for biofilm formation" /protein_id="NP_391703.2" /db_xref="EnsemblGenomes-Gn:BSU38240" /db_xref="EnsemblGenomes-Tr:CAB15850" /db_xref="GOA:P39599" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG10577" /db_xref="UniProtKB/Swiss-Prot:P39599" /translation="MNMTAFLLFLAIVGLTLIITYFAAKRTKTTSEFYTAGGGLTGVQ NGLAIAGDYMSAASFLGIAGMIALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYT MADMIAARFKEKKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGV LMTIYVVFGGMIATSWVQIIKAVLLMAGTLVISIIVFSKFGFSLNTMFEQMKTATPLG ADFLNPGNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIG VFYIMTVFLGFGAAAFVGFDAITAADQAGNMAAPLLAKALGGDFLFAFVSAIAFATIL AVVTGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSL NVAFLVALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWD PAGGAIFTGDPLIPLSNPGIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGV HMEQE*" /label="vbfA CDS" gene 3289357..3290898 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /label="vbfA gene" downshifts 3290889 /Source="Nicolas_upshifts" /id="D1979" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="2.40129" /MaxDrop="4.15104" /score="2.66606932" /energy="-7.8" /TU="NA" /idTUdmin="U3009" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3290929..3291531) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reductase" /protein_id="NP_391704.1" /db_xref="EnsemblGenomes-Gn:BSU38250" /db_xref="EnsemblGenomes-Tr:CAB15851" /db_xref="GOA:P39598" /db_xref="InterPro:IPR001853" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10576" /db_xref="UniProtKB/Swiss-Prot:P39598" /translation="MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPS PSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNK GHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKH AYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK*" /label="ywbO CDS" gene complement(3290929..3291531) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /label="ywbO gene" downshifts complement(3290943) /Source="Nicolas_upshifts" /id="D1980" /incds=0 /nref=12 /ntot=123 /MaxReadThrough="1.89374" /MaxDrop="3.51247" /score="21.9354981" /energy="-7.8" /TU="NA" /idTUdmin="U3011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3291532..3291813) /Source="Nicolas_S_feature" /locus_tag="new_3926400_3926681_c" /HighExp="T1.0H, G135, G150, T1.30H, Lbexp, G180, Lbstat, dia5, LBGexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.984, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1476" CDS complement(3291814..3293064) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /EC_number="1.11.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxidase converting ferric iron into ferrous iron" /protein_id="NP_391705.1" /db_xref="EnsemblGenomes-Gn:BSU38260" /db_xref="EnsemblGenomes-Tr:CAB15852" /db_xref="GOA:P39597" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR006313" /db_xref="InterPro:IPR006314" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019546" /db_xref="SubtiList:BG10575" /db_xref="UniProtKB/Swiss-Prot:P39597" /translation="MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTA AKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSL TQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKS KKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFV NKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFR KIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTG KQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTI GSALYACPGGCKKGEYIAQRLLES*" /label="efeB CDS" gene complement(3291814..3293064) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /label="efeB gene" downshifts complement(3291910) /Source="Nicolas_upshifts" /id="D1981" /incds=1 /nref=67 /ntot=232 /MaxReadThrough="5.0552" /MaxDrop="3.65898" /score="21.9354981" /energy="-7.8" /TU="U3011,U3012" /idTUdmin="U3011" /TUdmin="-967" /isTUend="FALSE" /label="downshifts" CDS complement(3293083..3294240) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipoprotein binding ferrous or ferric iron for transport" /protein_id="NP_391706.1" /db_xref="EnsemblGenomes-Gn:BSU38270" /db_xref="EnsemblGenomes-Tr:CAB15853" /db_xref="GOA:P39596" /db_xref="InterPro:IPR018976" /db_xref="InterPro:IPR034981" /db_xref="SubtiList:BG10574" /db_xref="UniProtKB/Swiss-Prot:P39596" /translation="MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEIT ASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHL QPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKE QSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDAREND VEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGA MELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDT EFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL*" /label="efeM CDS" gene complement(3293083..3294240) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /label="efeM gene" misc_feature complement(3293156..3293175) /Source="Nicolas_upshift_promotors" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3293183) /Source="Nicolas_upshifts" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3294237..3295682) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrous ion permease" /protein_id="NP_391707.2" /db_xref="EnsemblGenomes-Gn:BSU38280" /db_xref="EnsemblGenomes-Tr:CAB15854" /db_xref="GOA:P39595" /db_xref="InterPro:IPR004923" /db_xref="SubtiList:BG10573" /db_xref="UniProtKB/Swiss-Prot:P39595" /translation="MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDG DMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLE ELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVT SWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYS WWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTV LFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRS LLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGM RIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYS TIPQMLILLFLLIALVSEAAKHFTNGKELTK*" /label="efeU CDS" gene complement(3294237..3295682) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /label="efeU gene" promotor_-10 complement(3295716..3295735) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3295726) /Source="Nicolas_upshifts" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3295749..3295756) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3295839..3296507) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /EC_number="2.5.1.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10382260, 16291685, 19888457, 22616866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-phosphate pyrophosphorylase (thiamine phosphate synthase)" /protein_id="NP_391708.1" /db_xref="EnsemblGenomes-Gn:BSU38290" /db_xref="EnsemblGenomes-Tr:CAB15855" /db_xref="GOA:P39594" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR034291" /db_xref="InterPro:IPR036206" /db_xref="PDB:1G4E" /db_xref="PDB:1G4P" /db_xref="PDB:1G4S" /db_xref="PDB:1G4T" /db_xref="PDB:1G67" /db_xref="PDB:1G69" /db_xref="PDB:1G6C" /db_xref="PDB:2TPS" /db_xref="PDB:3O15" /db_xref="PDB:3O16" /db_xref="SubtiList:BG10572" /db_xref="UniProtKB/Swiss-Prot:P39594" /translation="MTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQ FREKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHIGQEDANA KEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTETKKDTRAVQGVSLIEA VRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEIQTY KTGR*" /label="thiE CDS" gene complement(3295839..3296507) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /label="thiE gene" downshifts complement(3295848) /Source="Nicolas_upshifts" /id="D1982" /incds=0 /nref=44 /ntot=194 /MaxReadThrough="1.62789" /MaxDrop="4.13196" /score="10.8502035" /energy="-10" /TU="NA" /idTUdmin="U3013" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3296504..3297322) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /EC_number="2.7.1.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10382260, 16291685, 22938038, 28729425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10382260, 16291685, 22938038, 28729425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-(2-hydroxyethyl)-4-methylthiazole kinase" /protein_id="NP_391709.1" /db_xref="EnsemblGenomes-Gn:BSU38300" /db_xref="EnsemblGenomes-Tr:CAB15856" /db_xref="GOA:P39593" /db_xref="InterPro:IPR000417" /db_xref="InterPro:IPR029056" /db_xref="PDB:1C3Q" /db_xref="PDB:1EKK" /db_xref="PDB:1EKQ" /db_xref="PDB:1ESJ" /db_xref="PDB:1ESQ" /db_xref="SubtiList:BG10571" /db_xref="UniProtKB/Swiss-Prot:P39593" /translation="MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPV MAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATP FRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQK LNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAA IAAISSYGVAAQLAAQQTADKGPGSFQIELLNKLSTVTEQDVQEWATIERVTVS*" /label="thiM CDS" gene complement(3296504..3297322) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /label="thiM gene" CDS complement(3297330..3298235) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23504016; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family, cidAB expression)" /protein_id="NP_391710.1" /db_xref="EnsemblGenomes-Gn:BSU38310" /db_xref="EnsemblGenomes-Tr:CAB15857" /db_xref="GOA:P39592" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10570" /db_xref="UniProtKB/Swiss-Prot:P39592" /translation="MDIRHLTYFLEVARLKSFTKASQSLYVSQPTISKMIKNLEEELG IELFYRNGRQVELTDAGHSMYVQAQEIIKSFQNLTSELNDIMEVKKGHVRIGLPPMIG SGFFPRVLGDFRENYPNVTFQLVEDGSIKVQEGVGDGSLDIGVVVLPANEDIFHSFTI VKETLMLVVHPSHRLADEKECQLRELKDEPFIFFREDFVLHNRIMTECIKAGFRPHII YETSQWDFISEMVSANLGIGLLPERICRGLDPEKVKVIPLVDPVIPWHLAIIWRKDRY LSFAARAWLEHTKSYLWDPKKDSKG*" /label="cidR CDS" gene complement(3297330..3298235) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /label="cidR gene" misc_feature complement(3297970..3297989) /Source="Nicolas_upshift_promotors" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3297981) /Source="Nicolas_upshifts" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3298276..3298295) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3298286..3298293 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3298297) /Source="Nicolas_upshifts" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" upshifts 3298305 /Source="Nicolas_upshifts" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3298307..3298326 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3298311..3298318) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3298341..3298727 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 22383849, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator of murein hydrolases" /protein_id="NP_391711.1" /db_xref="EnsemblGenomes-Gn:BSU38320" /db_xref="EnsemblGenomes-Tr:CAB15858" /db_xref="GOA:P39591" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023760" /db_xref="SubtiList:BG10569" /db_xref="UniProtKB/Swiss-Prot:P39591" /translation="MKKLLLTVIQIALLFIFARLINWVTALLHINIPGSIIGIVILFT LLHFNIIKLEWIELGAAWLLGELLLFFIPSAVGVIEYGDIMSKFGVSILLVVIISTFV VMVSTGTLTQLIAKRKEKKHTCSSEL*" /label="cidA CDS" gene 3298341..3298727 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /label="cidA gene" CDS 3298709..3299386 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator controlling activity of murein hydrolases" /protein_id="NP_391712.2" /db_xref="EnsemblGenomes-Gn:BSU38330" /db_xref="EnsemblGenomes-Tr:CAB15859" /db_xref="GOA:P39590" /db_xref="InterPro:IPR005261" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG10568" /db_xref="UniProtKB/Swiss-Prot:P39590" /translation="MFIGIVSLFLTVLVYLGAKKVYQRFPRVYTSPLLVTPAVLVGLL LLVNVPYESYNLGGGLLTDMLQPATVAFAIPLYKYFPVLKKYAVEIILNVAVGSCIAI ISTALIAKWLHLGTGLIDSLVPRSVTTPIAMNVSEMIGGMPAVTAVFVILTALLGTVI GPMVIRYFRIDNEIARGVLLGTSAHGAGTSKAFELSSVSGTISSVSMILAAIMTLCAA PFLLSFM*" /label="cidB CDS" gene 3298709..3299386 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /label="cidB gene" downshifts 3299358 /Source="Nicolas_upshifts" /id="D1983" /incds=0 /nref=13 /ntot=88 /MaxReadThrough="2.20109" /MaxDrop="4.23919" /score="27.0474383" /energy="-8" /TU="NA" /idTUdmin="U3015" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3299430..3299437 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3299448 /Source="Nicolas_upshifts" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3299451..3299470 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3299490..3300689 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar permease" /protein_id="NP_391713.1" /db_xref="EnsemblGenomes-Gn:BSU38340" /db_xref="EnsemblGenomes-Tr:CAB15860" /db_xref="GOA:P39589" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024989" /db_xref="InterPro:IPR026032" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10567" /db_xref="UniProtKB/Swiss-Prot:P39589" /translation="MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGS QVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFI LIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLY PIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTF APNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLS GGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMY AAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQ PAVTFKP*" /label="ywbF CDS" gene 3299490..3300689 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /label="ywbF gene" CDS 3300723..3300920 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391714.1" /db_xref="EnsemblGenomes-Gn:BSU38350" /db_xref="EnsemblGenomes-Tr:CAB15861" /db_xref="InterPro:IPR019240" /db_xref="SubtiList:BG10566" /db_xref="UniProtKB/Swiss-Prot:P39588" /translation="MNGQERNSISKGLQVDIVLKADQKTGKLTRGTVKDILTKSNFHP HGIKVRLEDGRIGRDQQIVST*" /label="ywbE CDS" gene 3300723..3300920 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /label="ywbE gene" downshifts 3300899 /Source="Nicolas_upshifts" /id="D1984" /incds=0 /nref=15 /ntot=205 /MaxReadThrough="1.90583" /MaxDrop="4.20528" /score="21.8132292" /energy="-12.2" /TU="NA" /idTUdmin="U3016" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(3300955..3302145) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18786544, 18789337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="large subunit ribosomal RNA m5C1962 methyltransferase" /protein_id="NP_391715.1" /db_xref="EnsemblGenomes-Gn:BSU38360" /db_xref="EnsemblGenomes-Tr:CAB15862" /db_xref="GOA:P39587" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019614" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10565" /db_xref="UniProtKB/Swiss-Prot:P39587" /translation="MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSE SGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAF RLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRF DTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRY AKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIK VMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGV IVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVL LQKK*" /label="rlmI CDS" gene complement(3300955..3302145) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /label="rlmI gene" downshifts complement(3300970) /Source="Nicolas_upshifts" /id="D1985" /incds=0 /nref=5 /ntot=127 /MaxReadThrough="0.0525399999999996" /MaxDrop="4.51664" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin=71 /isTUend="FALSE" /label="downshifts" downshifts complement(3301054) /Source="Nicolas_upshifts" /id="D1986" /incds=1 /nref=42 /ntot=233 /MaxReadThrough="2.99734" /MaxDrop="3.89369" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" misc_feature complement(3302169..3302188) /Source="Nicolas_upshift_promotors" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3302185) /Source="Nicolas_upshifts" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3302205..3302212 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3302221 /Source="Nicolas_upshifts" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3302226..3302245 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3302266..3302646 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24330391, 25283443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391, 25283443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase I; hemithioacetal-bacillithiol lactoyl-bacillithiol formation" /protein_id="NP_391716.1" /db_xref="EnsemblGenomes-Gn:BSU38370" /db_xref="EnsemblGenomes-Tr:CAB15863" /db_xref="GOA:P39586" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10564" /db_xref="UniProtKB/Swiss-Prot:P39586" /translation="MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELA FLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEIT TLPNGYRYFYIEGPDGEWIEFFQR*" /label="glxA CDS" gene 3302266..3302646 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /label="glxA gene" downshifts 3302544 /Source="Nicolas_upshifts" /id="D1987" /incds=1 /nref=14 /ntot=215 /MaxReadThrough="3.76076" /MaxDrop="3.68951" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-357" /isTUend="FALSE" /label="downshifts" downshifts 3302615 /Source="Nicolas_upshifts" /id="D1988" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="3.05249" /MaxDrop="3.56101" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" downshifts complement(3302691) /Source="Nicolas_upshifts" /id="D1989" /incds=0 /nref=6 /ntot=156 /MaxReadThrough="0.15283" /MaxDrop="5.41362" /score="0.491291944" /energy="-11.7" /TU="NA" /idTUdmin="U3020" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 3302706..3302707 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs27_020" promotor_-35 <3302707..3302710 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3302725..3302744 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3302744 /Source="Nicolas_upshifts" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3302956..3302963 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3302976..3302995 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3302976 /Source="Nicolas_upshifts" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="upshifts" CDS 3303028..3304407 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11580842, 1400159, 8535520, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11580842, 1400159, 8535520, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of SacY" /protein_id="NP_391720.1" /db_xref="EnsemblGenomes-Gn:BSU38410" /db_xref="EnsemblGenomes-Tr:CAB15867" /db_xref="GOA:P15400" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10560" /db_xref="UniProtKB/Swiss-Prot:P15400" /translation="MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAI ENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAA AFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLP ILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQG SMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQI MTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIW SMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAA IGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATL FLGFKEETE*" /label="sacX CDS" gene 3303028..3304407 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /label="sacX gene" S_feature complement(3304116..3305319) /Source="Nicolas_S_feature" /locus_tag="new_3943322_3944525_c" /HighExp="Etha, B36, B60, M9-stat, Salt, Sw, LoTm, C30, Gly, Heat" /AntisenseName="sacY" /AntisenseCor="-0.177403958488455" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1477" CDS 3304461..3305303 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9305644, 9457872, 11580842, 12079345, 15528654, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9305644, 9457872, 11580842, 12079345, 15528654, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391721.1" /db_xref="EnsemblGenomes-Gn:BSU38420" /db_xref="EnsemblGenomes-Tr:CAB15868" /db_xref="GOA:P15401" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1AUU" /db_xref="SubtiList:BG10559" /db_xref="UniProtKB/Swiss-Prot:P15401" /translation="MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIE KTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSF AIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIH TARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAG ESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQR SVAR*" /label="sacY CDS" gene 3304461..3305303 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /label="sacY gene" CDS complement(3305354..3306214) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11377871, 19659723; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase (general stress protein)" /protein_id="NP_391722.1" /db_xref="EnsemblGenomes-Gn:BSU38430" /db_xref="EnsemblGenomes-Tr:CAB15869" /db_xref="GOA:P25148" /db_xref="InterPro:IPR002495" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10558" /db_xref="UniProtKB/Swiss-Prot:P25148" /translation="MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVID GGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDE SIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSG IMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQT YIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKW NTIGNPAINQ*" /label="gspA CDS" gene complement(3305354..3306214) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /label="gspA gene" downshifts complement(3305364) /Source="Nicolas_upshifts" /id="D1991" /incds=0 /nref=73 /ntot=227 /MaxReadThrough="5.61926" /MaxDrop="7.47527" /score="21.8603429" /energy="-10.6" /TU="U3025" /idTUdmin="U3025" /TUdmin="-1224" /isTUend="FALSE" /label="downshifts" downshifts 3306198 /Source="Nicolas_upshifts" /id="D1992" /incds=0 /nref=8 /ntot=30 /MaxReadThrough="1.49599" /MaxDrop="5.33818" /score="10.6843241" /energy="-4.5" /TU="NA" /idTUdmin="U3026" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3306236..3306254) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3306254) /Source="Nicolas_upshifts" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3306269..3306275) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3306324..3307037) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391723.1" /db_xref="EnsemblGenomes-Gn:BSU38440" /db_xref="EnsemblGenomes-Tr:CAB15870" /db_xref="GOA:P25149" /db_xref="InterPro:IPR011737" /db_xref="SubtiList:BG10557" /db_xref="UniProtKB/Swiss-Prot:P25149" /translation="MQKYVQSDYKHDPFHLFSTEHVVTLAIISLLAILLFLFQDEVKQ PRASRFLRSLFVFLLLGSQIGYQIWMVATDRWSVRTSLPLQLSDLSVYLSAIMLVTKS RKLFVFLFFVGIGSSIQALATPDLGMFSFPHIRYILFFISHGSVFLSCLLMAVIGTYR MGQRSLWVTVLLVNVYGVCIFLIDRWLGANYMYLTKKPGGSSLLDVLGPWPWYIVSAE AITIASFFILYWLYRIFKK*" /label="ywaF CDS" gene complement(3306324..3307037) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /label="ywaF gene" promotor_-35 3306439..3306440 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3306460..3306477 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3306462 /Source="Nicolas_upshifts" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3307065..3307076) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3307066) /Source="Nicolas_upshifts" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3307091..3307097) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3307112..3307118 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3307133..3307152 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3307143 /Source="Nicolas_upshifts" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 3307188..3307703 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25733610; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling expressionof tyrZ" /protein_id="NP_391724.1" /db_xref="EnsemblGenomes-Gn:BSU38450" /db_xref="EnsemblGenomes-Tr:CAB15871" /db_xref="GOA:P25150" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10556" /db_xref="UniProtKB/Swiss-Prot:P25150" /translation="MERSHQHQQLRKEEHDTLSKLKQMPVESLNLEAISIATNLYRSA QRLRVKMETEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLE KKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGL LRKVADNLHTT*" /label="tyrZR CDS" gene 3307188..3307703 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /label="tyrZR gene" misc_RNA 3307704..3307910 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /product="T-box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboYB RNA" gene 3307704..3307910 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /label="tboYB gene" downshifts 3307870 /Source="Nicolas_upshifts" /id="D1993" /incds=0 /nref=15 /ntot=112 /MaxReadThrough="1.84575" /MaxDrop="4.56656" /score="23.8000948" /energy="-14.5" /TU="NA" /idTUdmin="U3028" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3307952..3309193 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /EC_number="6.1.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1735721, 1806041, 25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1735721, 1806041, 25733610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_391725.1" /db_xref="EnsemblGenomes-Gn:BSU38460" /db_xref="EnsemblGenomes-Tr:CAB15872" /db_xref="GOA:P25151" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024108" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10555" /db_xref="UniProtKB/Swiss-Prot:P25151" /translation="MMRTFEQLTASQQKEVERQLQLYMTGAHEVIPPEELKAKLVKSI STGTPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKS AARKQLTDEEVQHNAKTYFEQFGKVLDPEKVELHYNSKWLKTLNLEDVIELAGKITVA RLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLESDIELGGTDQHFNVLMGRHFQ ERYNKEKQVVILMPLLEGLDGVEKMSKSKHNYIGINEHPNDMYGKTMSLPDSLMKKYI HLATDLELEEKKQLVKDLETGAVHPRDAKMLLARTIVRMYHGEKAAEAAEHSFKTVFQ ENSLPEDIPAVNWKGEKTIAMIDLLVKLKLLSSKSEARRMIQNGGVRIDGEKVTDVHA KAEIRENMIIQVGKRKFLKLQ*" /label="tyrZ CDS" gene 3307952..3309193 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /label="tyrZ gene" promotor_-35 3309284..3309292 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3309303..3309321 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3309314 /Source="Nicolas_upshifts" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="upshifts" CDS 3309349..3310716 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15668014, 23426795, 26898926, 28257579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668014, 23426795, 26898926, 28257579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported double-zinc aminopeptidase" /protein_id="NP_391726.1" /db_xref="EnsemblGenomes-Gn:BSU38470" /db_xref="EnsemblGenomes-Tr:CAB15873" /db_xref="GOA:P25152" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR007484" /db_xref="SubtiList:BG10554" /db_xref="UniProtKB/Swiss-Prot:P25152" /translation="MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFK AKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTL SSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYE KAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLK LKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARV LKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASE LYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPE TEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDI FEDIK*" /label="eapD CDS" gene 3309349..3310716 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /label="eapD gene" downshifts 3310693 /Source="Nicolas_upshifts" /id="D1994" /incds=0 /nref=3 /ntot=37 /MaxReadThrough="1.38814" /MaxDrop="6.05871" /score="27.7635079" /energy="-13.3" /TU="NA" /idTUdmin="U3029" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(3310746..3311378) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /EC_number="2.7.6.5" /function="16.7: Manage energy" /function="16.3: Control" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_391727.1" /db_xref="EnsemblGenomes-Gn:BSU38480" /db_xref="EnsemblGenomes-Tr:CAB15874" /db_xref="GOA:P39583" /db_xref="InterPro:IPR007685" /db_xref="SubtiList:BG10553" /db_xref="UniProtKB/Swiss-Prot:P39583" /translation="MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYN LIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIY NVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTI AMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD*" /label="relQ CDS" gene complement(3310746..3311378) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /label="relQ gene" downshifts complement(3310764) /Source="Nicolas_upshifts" /id="D1995" /incds=0 /nref=200 /ntot=257 /MaxReadThrough="2.49976" /MaxDrop="5.49802" /score="47.236042" /energy="-13.3" /TU="NA" /idTUdmin="U3030" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3311414..3311429) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3311422) /Source="Nicolas_upshifts" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3311442..3311450) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3311520..3312455) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /EC_number="2.5.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6780514, 9573170, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-dihydroxy-2-naphthoate octaprenyltransferase" /protein_id="NP_391728.1" /db_xref="EnsemblGenomes-Gn:BSU38490" /db_xref="EnsemblGenomes-Tr:CAB15875" /db_xref="GOA:P39582" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR004657" /db_xref="InterPro:IPR026046" /db_xref="SubtiList:BG10552" /db_xref="UniProtKB/Swiss-Prot:P39582" /translation="MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVL AMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKP KTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRK TLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQ NEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR*" /label="menA CDS" gene complement(3311520..3312455) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /label="menA gene" downshifts complement(3311532) /Source="Nicolas_upshifts" /id="D1996" /incds=0 /nref=10 /ntot=113 /MaxReadThrough="3.08081" /MaxDrop="4.6874" /score="16.8971767" /energy="-8.5" /TU="NA" /idTUdmin="U3032" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3312199..3312208 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3312222..3312241 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3312226 /Source="Nicolas_upshifts" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3312456..3312543) /Source="Nicolas_S_feature" /locus_tag="new_3951662_3951749_c" /HighExp="LBGstat, Paraq, G180, LBGexp, G135, Oxctl, C30, Cold, Diami, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.81271400000000005" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.498" /TUlongSig="NA" /TUlongPSig="NA" /label="S1478" promotor_-10 complement(3312526..3312545) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3312543) /Source="Nicolas_upshifts" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3312561..3312565) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3312588..3312600) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3312588) /Source="Nicolas_upshifts" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3312615..3312621) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3312618..3312752) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514012.1" /translation="MECFELIHNKGKDTWSQKIFLTFKKCNVLKKIFLYLFVQVKAET *" /label="hypothetical protein CDS" gene complement(3312618..3312752) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /label="gene" promotor_-35 3312699..3312706 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-35" promotor_-10 3312720..3312739 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-10" upshifts 3312729 /Source="Nicolas_upshifts" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="upshifts" S_feature 3312732..3312836 /Source="Nicolas_S_feature" /locus_tag="new_3951938_3952042" /HighExp="H2O2, Paraq, Oxctl, G180, G150, C30, G135, LBGstat, dia15, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1479" promotor_-35 3312831..3312840 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3312838 /Source="Nicolas_upshifts" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3312852..3312867 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3312874) /Source="Nicolas_upshifts" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3312876..3312890) /Source="Nicolas_upshift_promotors" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3312902..3313051 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical membrane protein" /protein_id="YP_003097795.1" /db_xref="EnsemblGenomes-Gn:BSU38499" /db_xref="EnsemblGenomes-Tr:CAX52708" /db_xref="GOA:C0H3T3" /db_xref="InterPro:IPR021008" /db_xref="UniProtKB/Swiss-Prot:C0H3T3" /translation="MLQLMKQLYEKPAVKWTCHTGFYLMILLVLFFMYGFHTANTGSY IYNDF*" /label="ywzH CDS" gene 3312902..3313051 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /label="ywzH gene" CDS 3313069..3314580 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /EC_number="6.1.1.13" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine:D-alanyl-carrier protein ligase subunit" /protein_id="NP_391729.1" /db_xref="EnsemblGenomes-Gn:BSU38500" /db_xref="EnsemblGenomes-Tr:CAB15876" /db_xref="GOA:P39581" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010072" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:3E7W" /db_xref="PDB:3E7X" /db_xref="SubtiList:BG10551" /db_xref="UniProtKB/Swiss-Prot:P39581" /translation="MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQ KRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAEL LIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKD AVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSV AKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDE EGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIF CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHE FEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV*" /label="dltA CDS" gene 3313069..3314580 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /label="dltA gene" CDS 3314577..3315764 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 15849754, 16850406, 17263852; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine transferase from DCP to undecaprenylphosphate for lipoteichoic acid and wall teichoic acid" /protein_id="NP_391730.1" /db_xref="EnsemblGenomes-Gn:BSU38510" /db_xref="EnsemblGenomes-Tr:CAB15877" /db_xref="GOA:P39580" /db_xref="InterPro:IPR004299" /db_xref="InterPro:IPR024024" /db_xref="InterPro:IPR024194" /db_xref="SubtiList:BG10550" /db_xref="UniProtKB/Swiss-Prot:P39580" /translation="MTPYSSFLFFILLGILLLPTIILGLNGKRFQAYNMFISIIILAL IFSHDLHGVIALCLFTIWQVLLISGYLAYRQKANSGFVFCGAVIASILPLFLSKIWPF LSHPQPHHPPHNLISFLGISYLTFKGVQLIMEARDGLLKEQLPLHRLLYFILFFPTIS SGPIDRYRRFVKDEQKAWTKEEYADLLYTGIHKIFIGFLYKFIIGYAINTYFIMNLPA ITHNKILGNLLYMYGYSMYLFFDFAGYTMFAVGVSYIMGIKSPENFNKPFISKNIKDF WNRWHMSLSFWFRDYVFMRFVFWMTKKKWIKNRMAVSNIGYFLLFMLMGVWHGLAPQY IIYGLYHAVLMTCYNFFEKWNKKYKWLPSNRWTTILAIVITFHFVCFGFYIFSGKPFH HHH*" /label="dltB CDS" gene 3314577..3315764 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /label="dltB gene" CDS 3315781..3316017 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 26193422" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 26193422; Product type c: carrier" /codon_start=1 /transl_table=11 /product="D-alanyl carrier protein" /protein_id="NP_391731.1" /db_xref="EnsemblGenomes-Gn:BSU38520" /db_xref="EnsemblGenomes-Tr:CAB15878" /db_xref="GOA:P39579" /db_xref="InterPro:IPR003230" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:4BPF" /db_xref="PDB:4BPG" /db_xref="PDB:4BPH" /db_xref="SubtiList:BG10549" /db_xref="UniProtKB/Swiss-Prot:P39579" /translation="MDFKQEVLDVLAEVCQDDIVKENPDIEIFEEGLLDSFGTVELLL AIENRFDILVPITEFDRDVWNTPNNIVNQLSELK*" /label="dltC CDS" gene 3315781..3316017 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /label="dltC gene" CDS 3316017..3317195 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 17263852, 17600057, 23858088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine from undecaprenylphosphate tothe polyglycerolphosphate chain for lipoteichoic acid andwall teichoic acid synthesis" /protein_id="NP_391732.1" /db_xref="EnsemblGenomes-Gn:BSU38530" /db_xref="EnsemblGenomes-Tr:CAB15879" /db_xref="GOA:P39578" /db_xref="InterPro:IPR006998" /db_xref="InterPro:IPR023896" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG10548" /db_xref="UniProtKB/Swiss-Prot:P39578" /translation="MKKRFFGPIILAFILFAGAIAIPSSWLTGFITDKRVKESATALN PSMFQGLYLQDQMLKDPTYLPIYGSSELSRLDEFHPSNYFQVNNEGFTPYLVGKGGSQ SLIHSLNFAAHMDQLKGKKIVFIVSPQWFIKRGSDEQHFAPNYSALQGLDLAFNDQID PEIKKKMMKRMLRFKAVQNDAILSELYKAMVNGQTWKVNALKPAAKVYYSMLEKKDLY YSTTESSGPKRYISQSVKDKSWSELNKLADQSGKRHSGSNDFHIDNPVYKKLKPKVPK LKGKNKGRSYAVSPEYGDFEMMLDILKDAGAEPMFVTIPVNGKWYDYTGFPKKGRTDY YKKVNKQIRAKGFQVADFSGHEYDPYFMKDTIHIGWKGWVYVDKAIDEFYKTGKVTSS *" /label="dltD CDS" gene 3316017..3317195 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /label="dltD gene" S_feature 3317196..3317285 /Source="Nicolas_S_feature" /locus_tag="new_3956402_3956491" /HighExp="Paraq, H2O2, Oxctl, LBGexp, Lbexp, dia0, C30, Cold, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1480" CDS 3317286..3318044 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7797557, 14665680; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391733.2" /db_xref="EnsemblGenomes-Gn:BSU38540" /db_xref="EnsemblGenomes-Tr:CAB15880" /db_xref="GOA:P39577" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10547" /db_xref="UniProtKB/Swiss-Prot:P39577" /translation="MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAE AKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELF VDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALH SFSLTLRHQLRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLK EGKQEITNERVEGLRDATRADYDRLFEQMNTQEN*" /label="dltE CDS" gene 3317286..3318044 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /label="dltE gene" downshifts 3318012 /Source="Nicolas_upshifts" /id="D1997" /incds=0 /nref=48 /ntot=172 /MaxReadThrough="5.94016" /MaxDrop="4.72547" /score="22.6844301" /energy="-13.7" /TU="U3035" /idTUdmin="U3035" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature complement(3318046..3319273) /Source="Nicolas_S_feature" /locus_tag="new_3957252_3958479_c" /HighExp="T0.30H, T1.0H, T1.30H, C30, B60, T2.0H, C90, Gly, T2.30H, S8" /AntisenseName="ilvK" /AntisenseCor="-0.12928749136401099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1481" promotor_-35 3318092..3318099 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3318113..3318132 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3318126 /Source="Nicolas_upshifts" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="upshifts" CDS 3318185..3319276 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 17611193, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 17611193, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid aminotransferase" /protein_id="NP_391734.2" /db_xref="EnsemblGenomes-Gn:BSU38550" /db_xref="EnsemblGenomes-Tr:CAB15881" /db_xref="GOA:P39576" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10546" /db_xref="UniProtKB/Swiss-Prot:P39576" /translation="MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGW YDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDR LCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLL IILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFS QVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQV SERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKL YDTITGIQKGAVADEFGWTTEVAALTESK*" /label="ilvK CDS" gene 3318185..3319276 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /label="ilvK gene" downshifts 3319178 /Source="Nicolas_upshifts" /id="D1998" /incds=1 /nref=10 /ntot=90 /MaxReadThrough="6.0829" /MaxDrop="3.1965" /score="32.8755878" /energy="-13.6" /TU="U3035,U3037" /idTUdmin="U3035" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 3319266 /Source="Nicolas_upshifts" /id="D1999" /incds=0 /nref=157 /ntot=264 /MaxReadThrough="2.21106" /MaxDrop="6.83094" /score="32.8755878" /energy="-13.6" /TU="NA" /idTUdmin="U3035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3319310..3320638) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8990303, 10438772, 22720735, 23874669, 24673833; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-beta-glucosidase" /protein_id="NP_391735.1" /db_xref="EnsemblGenomes-Gn:BSU38560" /db_xref="EnsemblGenomes-Tr:CAB15882" /db_xref="GOA:P46320" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11350" /db_xref="UniProtKB/Swiss-Prot:P46320" /translation="MTKGLKIVTIGGGSSYTPELVEGFIKRYDELPVRELWLVDIPEG EEKLNIVGTLAKRMVEKAGVPIDIHLTLDRRKALKDADFVTTQFRVGLLQARAKDERI PLKYGVIGQETNGPGGLFKGLRTIPVILEIAKDIEELCPNAWLVNFTNPAGMVTEALL RYSNLKKVVGLCNVPIGIKMGVAKALDVDVDRVEVQFAGLNHMVFGLDVFLDGVSVKE QVIEAMGDPKNAMTMKNISGAEWEPDFLKALNVIPCGYHRYYFKTKEMLEHELEASQT EGTRAEVVQKVEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACNLISSIYNDKHDIQ PVNTINNGAIASIPDDSAVEVNCVMTKTGPKPIAVGDLPVSVRGLVQQIKSFERVAAE AAVTGDYQTALLAMTINPLVPSDTVAKQILDEMLEAHKAYLPQFFNKIEA*" /label="licH CDS" gene complement(3319310..3320638) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /label="licH gene" downshifts complement(3319318) /Source="Nicolas_upshifts" /id="D2000" /incds=0 /nref=12 /ntot=98 /MaxReadThrough="4.92442" /MaxDrop="6.75565" /score="45.1562234" /energy="-15.7" /TU="U3038" /idTUdmin="U3038" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" CDS complement(3320635..3320967) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIA component" /protein_id="NP_391736.1" /db_xref="EnsemblGenomes-Gn:BSU38570" /db_xref="EnsemblGenomes-Tr:CAB15883" /db_xref="GOA:P46319" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG11349" /db_xref="UniProtKB/Swiss-Prot:P46319" /translation="MNEEMEQIIFQIILHGGNGRSSAMEAIAAAKSGDAEEARKKLQD AAEELSKAHHYQTELIQNEAGGEKTEMTLLMVHAQDHLMNAMTVKDMAAEIIELYEKI TEQRGASI*" /label="licA CDS" gene complement(3320635..3320967) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /label="licA gene" CDS complement(3320986..3322344) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIC component" /protein_id="NP_391737.1" /db_xref="EnsemblGenomes-Gn:BSU38580" /db_xref="EnsemblGenomes-Tr:CAB15884" /db_xref="GOA:P46317" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG11348" /db_xref="UniProtKB/Swiss-Prot:P46317" /translation="MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSF FLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVD ALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVST EIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNI VSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIA FQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFN INEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFS GYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEA AL*" /label="licC CDS" gene complement(3320986..3322344) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /label="licC gene" CDS complement(3322360..3322668) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 23874669; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIB component" /protein_id="NP_391738.1" /db_xref="EnsemblGenomes-Gn:BSU38590" /db_xref="EnsemblGenomes-Tr:CAB15885" /db_xref="GOA:P46318" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11347" /db_xref="UniProtKB/Swiss-Prot:P46318" /translation="MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNH IDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS *" /label="licB CDS" gene complement(3322360..3322668) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /label="licB gene" promotor_-10 complement(3322713..3322732) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3322729) /Source="Nicolas_upshifts" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3322746..3322752) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3322797) /Source="Nicolas_upshifts" /id="D2001" /incds=0 /nref=3 /ntot=74 /MaxReadThrough="3.19679" /MaxDrop="2.70222" /score="27.6067633" /energy="-11.1" /TU="U3040" /idTUdmin="U3040" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3322797..3324722) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 9353933, 10438772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 9353933, 10438772; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the lichenan operon" /protein_id="NP_391739.1" /db_xref="EnsemblGenomes-Gn:BSU38600" /db_xref="EnsemblGenomes-Tr:CAB15886" /db_xref="GOA:P46321" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG11346" /db_xref="UniProtKB/Swiss-Prot:P46321" /translation="MLHGRLRDILRLLMAAEAPVTSSFFAAQLNVTTRTVRNDIKELQ GVLSGHGAFVQSVRGSGYKLRIDDEQVFRTLLQDEFQQKKGLPVLPEERMAYLMKRLL LADHYLKLDELAEELFISKSTLQTDLKEVKKRLLPYRIVMETRPNYGFKLRGDEVQMR YCMAEYIVDERETEIDVLNEKADILPKEEIEIIRSAILKKMKNDRIPLSNMGLNNLII HIAIACKRIRTENYVSLFPKDMDHILHQKEYQAAEAIVKELESKLSVTFPKDETAYIT MHLLGTKRMTQSQCGEDTFSIEEETDQLTLAMIKAVDRELKLGILHDKELKIGLALHM KPAISRNRYGMNLRNPMLAAIKEHYPLAFEAGIIAGIVIKEQTGIEIHENEIGYLALH FGAAIERKKTESPPKRCIIVCASGAGSAQLLREKLRSHFGKRLDILGTAEYYSLDQMS YESIDFVISTIPIKKELPVPVLKVNTILGGTDFTKIESILSDEKEKANRYLKKELVFF QEDLRSKEEVIQFLGQKVVECGFADEEIIDSIFEREDMSPTCFGNLVAIPHPLVPQTK TTFWAVCTLKKPIDWESQRVQFVCLLCVEKENKADLQSMYKLLGSILDDPAAMNQLIK CRSYQELSDVFDQKMLS*" /label="licR CDS" gene complement(3322797..3324722) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /label="licR gene" promotor_-35 3323460..3323469 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3323483..3323502 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3323491 /Source="Nicolas_upshifts" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3324795..3324812) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-10" upshifts complement(3324819) /Source="Nicolas_upshifts" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="upshifts" promotor_-35 complement(3324827..3324834) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-35" CDS complement(3324885..3325043) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391740.1" /db_xref="EnsemblGenomes-Gn:BSU38610" /db_xref="EnsemblGenomes-Tr:CAB15887" /db_xref="SubtiList:BG14169" /db_xref="UniProtKB/Swiss-Prot:O32283" /translation="MVEKKEGRIGALKKMIKTVIKWAPVIYPIVRKIMKDRKASKQKN MSASRTAG*" /label="yxzF CDS" gene complement(3324885..3325043) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /label="yxzF gene" downshifts complement(3324912) /Source="Nicolas_upshifts" /id="D2002" /incds=0 /nref=75 /ntot=208 /MaxReadThrough="0.739420000000001" /MaxDrop="6.4099" /score="27.6067633" /energy="-11.1" /TU="NA" /idTUdmin="U3041" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3325072..3325662) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /EC_number="3.2.2.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14729667, 27698084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14729667, 27698084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-alkylated purines and hypoxanthine DNA glycosidase" /protein_id="NP_391741.1" /db_xref="EnsemblGenomes-Gn:BSU38620" /db_xref="EnsemblGenomes-Tr:CAB15888" /db_xref="GOA:P94378" /db_xref="InterPro:IPR003180" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036995" /db_xref="SubtiList:BG12555" /db_xref="UniProtKB/Swiss-Prot:P94378" /translation="MTREKNPLPITFYQKTALELAPSLLGCLLVKETDEGTASGYIVE TEAYMGAGDRAAHSFNNRRTKRTEIMFAEAGRVYTYVMHTHTLLNVVAAEEDVPQAVL IRAIEPHEGQLLMEERRPGRSPREWTNGPGKLTKALGVTMNDYGRWITEQPLYIESGY TPEAISTGPRIGIDNSGEARDYPWRFWVTGNRYVSR*" /label="aag CDS" gene complement(3325072..3325662) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /label="aag gene" promotor_-10 complement(3325690..3325708) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3325701) /Source="Nicolas_upshifts" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3325722..3325728) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3325731..3325737 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3325753..3325771 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3325756 /Source="Nicolas_upshifts" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="upshifts" CDS 3325791..3327434 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9393707, 9555886, 10503549, 24123749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9555886, 10503549, 24123749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="major catalase in spores" /protein_id="NP_391742.1" /db_xref="EnsemblGenomes-Gn:BSU38630" /db_xref="EnsemblGenomes-Tr:CAB15889" /db_xref="GOA:P94377" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11945" /db_xref="UniProtKB/Swiss-Prot:P94377" /translation="MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVT DNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDE PISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVG NNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGI PANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQ DLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKN PENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPK KHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREA IDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKR VAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY*" /label="katX CDS" gene 3325791..3327434 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /label="katX gene" S_feature complement(3325928..3327477) /Source="Nicolas_S_feature" /locus_tag="new_3965134_3966683_c" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T3.0H, S8, T3.30H, S6, T0.0H" /AntisenseName="katX" /AntisenseCor="0.28909015498211399" /AntisenseRegPval="-5.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1482" downshifts 3327429 /Source="Nicolas_upshifts" /id="D2003" /incds=0 /nref=28 /ntot=49 /MaxReadThrough="0.942820000000001" /MaxDrop="5.69337" /score="45.0252072" /energy="-12.7" /TU="NA" /idTUdmin="U3042" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3327479..3327570) /Source="Nicolas_S_feature" /locus_tag="new_3966685_3966776_c" /HighExp="T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, T3.30H, T4.0H, T3.0H, T0.0H, T5.0H" /AntisenseName="yxlH" /AntisenseCor="-4.8005444617814199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1483" promotor_-35 3327481..3327487 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3327495 /Source="Nicolas_upshifts" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3327502..3327521 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3327522) /Source="Nicolas_upshifts" /id="D2004" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="3.81662" /MaxDrop="3.1285" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1557" /isTUend="FALSE" /label="downshifts" CDS 3327539..3328741 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391743.1" /db_xref="EnsemblGenomes-Gn:BSU38640" /db_xref="EnsemblGenomes-Tr:CAB15890" /db_xref="GOA:P94376" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12554" /db_xref="UniProtKB/Swiss-Prot:P94376" /translation="MELQQDLIPQKKTIGALDHAVFLCMVFCFWFSGYIYVPVFSLYL EDLHFSYGAIGIILGSYGVTQILLRFPLGLLSDILFSLRKQLLIAGFGFSVLSSLLFL MFDSFFFVLAARLFAGITASTWVMATILYAHYFNNGNASKAMGIMQFFTVMPQFASIV FCGLAAAHLGRQVPFWMALAASAAGLVICCFIQDPSAPPANRGTIRVNQYIKDTLRLP KLKLFTILSMTAHAVLFITVFGFTPLYMNQLGMGDAELLWVMSAFFLPHAAATLSFVF LRFTSRIAYSVMLISFAVTGVCLLYVPFLAALFTVCITHACIGLALGFVFPLLLSHVV EISSARLKMSVMGFYQSFYALGIFLGPLLAGKIAQLIGLAGVFYGAGSLAFAAFFVML AQKRNMIN*" /label="yxlH CDS" gene 3327539..3328741 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /label="yxlH gene" S_feature complement(3327572..3328737) /Source="Nicolas_S_feature" /locus_tag="new_3966778_3967943_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T0.0H, T3.0H, T3.30H, T-0.40H, T4.0H" /AntisenseName="yxlH" /AntisenseCor="-4.5703316381945601E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1484" downshifts complement(3327615) /Source="Nicolas_upshifts" /id="D2005" /incds=1 /nref=3 /ntot=61 /MaxReadThrough="6.44992" /MaxDrop="2.92619" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS complement(3328738..3329514) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC-transporter (permease)" /protein_id="NP_391744.2" /db_xref="EnsemblGenomes-Gn:BSU38650" /db_xref="EnsemblGenomes-Tr:CAB15891" /db_xref="GOA:P94375" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12553" /db_xref="UniProtKB/Swiss-Prot:P94375" /translation="MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPE IIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTA LIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLY ALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAE HILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY*" /label="yxlG CDS" gene complement(3328738..3329514) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /label="yxlG gene" CDS complement(3329511..3330398) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter component (ATP-binding protein)" /protein_id="NP_391745.1" /db_xref="EnsemblGenomes-Gn:BSU38660" /db_xref="EnsemblGenomes-Tr:CAB15892" /db_xref="GOA:P94374" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12552" /db_xref="UniProtKB/Swiss-Prot:P94374" /translation="MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTL QMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKR KCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDP TGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQ TNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVT RFEQKTESLEDVYLKVVHA*" /label="yxlF CDS" gene complement(3329511..3330398) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /label="yxlF gene" CDS complement(3330405..3330593) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma-Y activity" /protein_id="NP_391746.1" /db_xref="EnsemblGenomes-Gn:BSU38670" /db_xref="EnsemblGenomes-Tr:CAB15893" /db_xref="GOA:P94373" /db_xref="InterPro:IPR027379" /db_xref="SubtiList:BG12551" /db_xref="UniProtKB/Swiss-Prot:P94373" /translation="MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIV CINIIGPILFFTVGRKQR*" /label="yxlE CDS" gene complement(3330405..3330593) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /label="yxlE gene" CDS complement(3330590..3330796) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative sigma-Y antisigma factor component" /protein_id="NP_391747.1" /db_xref="EnsemblGenomes-Gn:BSU38680" /db_xref="EnsemblGenomes-Tr:CAB15894" /db_xref="GOA:P94372" /db_xref="SubtiList:BG12550" /db_xref="UniProtKB/Swiss-Prot:P94372" /translation="MTQTEIIITVAACLIVLAQGIFLFIDAKKRNHMAWVWGIVGLIQ APMPLICYYFFVIRPDRKKRGIKQ*" /label="yxlD CDS" gene complement(3330590..3330796) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /label="yxlD gene" CDS complement(3330793..3331113) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sigma-Y antisigma factor" /protein_id="NP_391748.1" /db_xref="EnsemblGenomes-Gn:BSU38690" /db_xref="EnsemblGenomes-Tr:CAB15895" /db_xref="GOA:P94371" /db_xref="InterPro:IPR035238" /db_xref="SubtiList:BG12549" /db_xref="UniProtKB/Swiss-Prot:P94371" /translation="MNKEKLSDHLKSEWKKIDQTANPSIPNQKELLHQLSQMKAEYRK KLLQEIILFVFCALMVVSAAILAFTQAPAVFIVLQVCVLAVLPILIAAEKKRHLGECE VKRG*" /label="yxlC CDS" gene complement(3330793..3331113) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /label="yxlC gene" promotor_-35 3330926..3330935 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3330948..3330967 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3330950 /Source="Nicolas_upshifts" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3331106..3331642) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y)" /protein_id="NP_391749.1" /db_xref="EnsemblGenomes-Gn:BSU38700" /db_xref="EnsemblGenomes-Tr:CAB15896" /db_xref="GOA:P94370" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11975" /db_xref="UniProtKB/Swiss-Prot:P94370" /translation="MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPD LSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEE TIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTV KSRVHKGLQQIRKEWDDE*" /label="sigY CDS" gene complement(3331106..3331642) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /label="sigY gene" upshifts complement(3331670) /Source="Nicolas_upshifts" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3331671..3331686) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3331698..3331707) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3331773..3331780 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3331794..3331813 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3331803 /Source="Nicolas_upshifts" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="upshifts" CDS 3331854..3333227 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2191181, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine-cytosine (pyridoxine) permease" /protein_id="NP_391750.1" /db_xref="EnsemblGenomes-Gn:BSU38710" /db_xref="EnsemblGenomes-Tr:CAB15897" /db_xref="GOA:P94369" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR026030" /db_xref="SubtiList:BG12548" /db_xref="UniProtKB/Swiss-Prot:P94369" /translation="MKVERRTIEYIPNEERHGKAKDLFPVWFGANMHITTLVTGTIPV AMGLNLFWSVAAIICGTLIGAIFMASHSAQGPQLGIPQMIQSRAQFGVIGAILPLFLV MFIYLGFFASSTILAAGTLSSFVPIPGSWSIIGLSAVCFLLTIFGHDLIHKMQKILSW TSFAVFFAATILIFQLPIPAGSWIPGAIDLPIFLVAVSAVATWQLAYAPYVADYSRYL PVKTPASKTFWYSYAGTSVSSIWMMLLGALLTTSLPDFTANSGSQIVQLFGPFSFIML IIVLFGQMAINVFNLYGAFMSTTTTLEPFLKLKVTPKVRIIMILGVTLVGTVLSLLGQ SNFMELFLNFIFFISYFLIPWTAINLVDYYFVRHGKYQVKAMFDVNGPYGKVNWITTI AFVLSILLEIPFINTSFYIGPLAKMFGGGDIAWIIGLAVPSVLYYVLMKPRLKKRAGY QEKLSSL*" /label="yxlA CDS" gene 3331854..3333227 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /label="yxlA gene" S_feature complement(3332134..3332676) /Source="Nicolas_S_feature" /locus_tag="new_3971340_3971882_c" /HighExp="Etha, LBGstat, T1.0H, T0.30H, Diami, T1.30H, dia15, G150, G135, G180" /AntisenseName="yxlA" /AntisenseCor="-8.6586358833710395E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1485" promotor_-10 complement(3332664..3332683) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3332676) /Source="Nicolas_upshifts" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3332698..3332705) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3333062 /Source="Nicolas_upshifts" /id="D2006" /incds=1 /nref=30 /ntot=136 /MaxReadThrough="1.87017" /MaxDrop="3.59478" /score="22.3054019" /energy="-12.9" /TU="NA" /idTUdmin="U3046" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3333242..3334072) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12457846, 21994945, 22940582, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12457846, 21994945, 22940582, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H dehydratase" /protein_id="NP_391751.1" /db_xref="EnsemblGenomes-Gn:BSU38720" /db_xref="EnsemblGenomes-Tr:CAB15898" /db_xref="GOA:P94368" /db_xref="InterPro:IPR000631" /db_xref="InterPro:IPR017953" /db_xref="InterPro:IPR029056" /db_xref="PDB:1KYH" /db_xref="PDB:3RPH" /db_xref="PDB:3RPZ" /db_xref="PDB:3RQ2" /db_xref="PDB:3RQ5" /db_xref="PDB:3RQ6" /db_xref="PDB:3RQ8" /db_xref="PDB:3RQH" /db_xref="PDB:3RQQ" /db_xref="PDB:3RQX" /db_xref="SubtiList:BG12547" /db_xref="UniProtKB/Swiss-Prot:P94368" /translation="MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAAL LAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIG PGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVP VNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTL TGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE *" /label="nnrA CDS" gene complement(3333242..3334072) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /label="nnrA gene" downshifts complement(3333248) /Source="Nicolas_upshifts" /id="D2007" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="3.50755" /MaxDrop="3.84264" /score="7.61210868" /energy="-12.9" /TU="U3048" /idTUdmin="U3051" /TUdmin=792 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3334091..3334109) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3334106) /Source="Nicolas_upshifts" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3334124..3334130) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3334150) /Source="Nicolas_upshifts" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3334152..3334171) /Source="Nicolas_upshift_promotors" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3334158..3335885) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391752.1" /db_xref="EnsemblGenomes-Gn:BSU38730" /db_xref="EnsemblGenomes-Tr:CAB15899" /db_xref="GOA:P94367" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11928" /db_xref="UniProtKB/Swiss-Prot:P94367" /translation="MKKEEWILPYIKQNARLFVLVIFLGAVTIFSAAFLMFTSGFLIS KAATRPENILLIYVPIVAVRTFGIARSVSRYVERLVGHHIILKIVSDMRVRLYNMLEP GALMLRSRFRTGDMLGILSEDIEHLQDAFLKTIFPAISALLLYAVSVIALGFFSWPFA ILLALYLFVLVVLFPVVSLLVTRAKNAKLKSGRNVLYSRLTDAVMGVSDWMFSGRRHA FIDAYEKEERDWFELERKKQRFTRWRDFAAQCLVAGLILLMLFWTAGQQADGELAKTM IAAFVLVVFPLTEAFLPLSDALGEVPGYQDSIRRMNNVAPQPEASQTESGDQILDLQD VTLAFRDVTFSYDNSSQVLHNFSFTLRQGEKMALLGRSGSGKSTSLALIEGALKPDSG SVTLNGVETALLKDQIADAVAVLNQKPHLFDTSILNNIRLGNGEASDEDVRRAAKQVK LHDYIESLPDGYHTSVQETGIRFSGGERQRIALARILLQDTPIIILDEPTVGLDPITE RELMETVFEVLKGKTILWITHHLAGVEAADKIVFLENGKTEMEGTHEELLAANERYRR LYHLDVPVK*" /label="cydD CDS" gene complement(3334158..3335885) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /label="cydD gene" downshifts complement(3334257) /Source="Nicolas_upshifts" /id="D2008" /incds=1 /nref=7 /ntot=46 /MaxReadThrough="5.39758" /MaxDrop="3.66431" /score="25.0271963" /energy="-10.6" /TU="U3051" /idTUdmin="U3051" /TUdmin="-217" /isTUend="FALSE" /label="downshifts" CDS complement(3335882..3337585) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391753.1" /db_xref="EnsemblGenomes-Gn:BSU38740" /db_xref="EnsemblGenomes-Tr:CAB15900" /db_xref="GOA:P94366" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11927" /db_xref="UniProtKB/Swiss-Prot:P94366" /translation="MGKDLFRYKGMKRILTLITCLTLIQTAAIIMQAEWLSEAVTGLF NGKGITSLLPVIGFFLIAFIARHGMTVARQKIVYQYAARTGADLRKSFLDQLFRLGPR FAKKEGTGQMVTLAMEGISQFRRYLELFLPKMVSMAIVPAAVVIYVFFQDRTSAIILV AAMPILIIFMILLGLVAQRKADRQWKSYQRLSNHFVDSLRGLETLRFLGLSKSHSKNI FYVSERYRKATMSTLRVAFLSSFALDFFTMLSVATVAVFLGLRLIDGDILLGPALTAL ILAPEYFLPVREVGNDYHATLNGQEAGKTIQEILSQPGFKEETPLQLEAWSDQDELKL SGVSVGRSVSDIHLSFKGKKKIGIIGASGAGKSTLIDILGGFLEPDGGMIEVNGTSRS HLQDGSWQKNLLYIPQHPYIFDDTLGNNIRFYHPSASAEDTTRAAASAGLTELVNNLP DGLEGRIGEGGRALSGGQAQRVALARAFLGNRPILLLDEPTAHLDIETEYEIKETMLD LFEDKLVFLATHRLHWMLDMDEIIVLDGGRVAEIGTHNELLEKNGVYTKLVKAQLGER A*" /label="cydC CDS" gene complement(3335882..3337585) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /label="cydC gene" CDS complement(3337585..3338601) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit II)" /protein_id="NP_391754.1" /db_xref="EnsemblGenomes-Gn:BSU38750" /db_xref="EnsemblGenomes-Tr:CAB15901" /db_xref="GOA:P94365" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG11926" /db_xref="UniProtKB/Swiss-Prot:P94365" /translation="MASLHDLWFILVAVLFVGFFFLEGFDFGVGMATRFLGHNELERR VLINTIGPFWDANEVWLLTGAGAIFAAFPNWYATMLSGYYIPFVIVLLALMGRGVAFE FRGKVDHLKWVKVWDWVVFFGSLIPPFVLGVLFTTLFRGMPIDADMNIHAHVSDYINV YSILGGVTVTLLCFQHGLMFITLRTIGDLQNRARKMAQKIMGVVFVAVLAFAALSAYQ TDMFTRRGEITIPLAVLIVICFMLAAVFIRKKKDGWTFGMTGAGLALTVGMIFISLFP RVMVSSLHSAYDLTVANASSGDYSLKVMSIAALTLLPFVIGSQIWSYYVFRKRVSHKE PMTY*" /label="cydB CDS" gene complement(3337585..3338601) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /label="cydB gene" promotor_-10 complement(3338475..3338493) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3338484) /Source="Nicolas_upshifts" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3338509..3338514) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3338585..3339991) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit I)" /protein_id="NP_391755.1" /db_xref="EnsemblGenomes-Gn:BSU38760" /db_xref="EnsemblGenomes-Tr:CAB15902" /db_xref="GOA:P94364" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG11925" /db_xref="UniProtKB/Swiss-Prot:P94364" /translation="MSELVLARIQFASTTLFHFLFVPMSIGLVFMVALMETLYLVKKN ELYLKMAKFWGHLFLINFAVGVVTGILQEFQFGLNWSDYSRFVGDVFGAPLAIEALLA FFMESIFIGLWIFGWDRLPKKIHALCIWLVSFGTIMSSFWILTANSFMQEPVGFTIKN GRAEMNDFGALITNPQLWVEFPHVIFGALATGAFFIAGVSAFKLLKKKEVPFFKQSFK LAMIVGLCAGLGVGLSGHMQAEHLMESQPMKMAASEGLWEDSGDPAAWTAFATIDTKN EKSSNEIKVPYALSYLAYQKFSGSVKGMKTLQAEYEKIYGKGDYIPPVKTTFWSFRIM VGAGVVMILAALGGLWLNRRKKLENSKWYLRIMIALISFPFLANSAGWIMTEIGRQPW TVMGLMTTAQSVSPNVTAGSLLFSIIAFGVMYMILGALLVFLFIREIKKGAEHDNHHD VPVSTDPFSQEVYHGISS*" /label="cydA CDS" gene complement(3338585..3339991) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /label="cydA gene" S_feature complement(3339992..3340200) /Source="Nicolas_S_feature" /locus_tag="new_3979198_3979406_c" /HighExp="M0t45, ferm, UNK1, Gly, Lbexp, Lbstat, dia0, nit, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1486" promotor_-10 complement(3340183..3340202) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3340200) /Source="Nicolas_upshifts" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3340202..3340310) /Source="Nicolas_S_feature" /locus_tag="new_3979408_3979516_c" /HighExp="LPhT, LBGtran, ferm, LBGstat, M0t45, dia0, Etha, dia5, Lbexp, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1487" promotor_-35 complement(3340216..3340221) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3340307..3340326) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-10" upshifts complement(3340322) /Source="Nicolas_upshifts" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="upshifts" promotor_-35 complement(3340340..3340347) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-35" promotor_-35 3340468..3340475 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3340485 /Source="Nicolas_upshifts" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3340490..3340508 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3340547..3341899 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11566984, 12525174, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11566984, 12525174, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="citrate/malate/H+ symporter" /protein_id="NP_391756.1" /db_xref="EnsemblGenomes-Gn:BSU38770" /db_xref="EnsemblGenomes-Tr:CAB15903" /db_xref="GOA:P94363" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12546" /db_xref="UniProtKB/Swiss-Prot:P94363" /translation="MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALL FILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAV VYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAF ALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFN LSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVS RFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMY PIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY *" /label="cimH CDS" gene 3340547..3341899 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /label="cimH gene" S_feature complement(3341498..3343980) /Source="Nicolas_S_feature" /locus_tag="new_3980704_3983186_c" /HighExp="Cold, C30, LBGstat, Paraq, GM 120, GM 90, H2O2, Oxctl, GM 25, GM 45" /AntisenseName="yxkI" /AntisenseCor="0.564471040461903" /AntisenseRegPval="-23.3" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1488" downshifts 3341884 /Source="Nicolas_upshifts" /id="D2009" /incds=0 /nref=63 /ntot=147 /MaxReadThrough="2.93791" /MaxDrop="3.97692" /score="3.68725156" /energy="-12.7" /TU="U3053" /idTUdmin="U3053" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3341975..3341994 /Source="Nicolas_upshift_promotors" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3341981 /Source="Nicolas_upshifts" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="upshifts" CDS 3342021..3343709 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_391757.1" /db_xref="EnsemblGenomes-Gn:BSU38780" /db_xref="EnsemblGenomes-Tr:CAB15904" /db_xref="GOA:P94362" /db_xref="InterPro:IPR001915" /db_xref="SubtiList:BG12545" /db_xref="UniProtKB/Swiss-Prot:P94362" /translation="MPMGTHLFLFMLLGLGFYLISALAAKLIPAIDFWIDIVLWVGAA AYIFSHLSFMDGIVSLATMFYCYWTAMDLIVSERVEKPSGDWQEIELAKNKTRLLSDI TLTAIVFAGAVIFFIYGPDTSPLKYVILLGMISGGGALVKRILNVFSVKVFYSAALEK LHISSHYETRTYPLSDLKNIQLESTADLLKLHPLLTMYSSRLDLTTSFQQVIKLSLPG ETLFLTVKEPQKWKTILQEYTDAENNVDNVISVLPFYHRKNVKRLLGKLYFAASVKGV SAYALLVLALYALHASPWVMAVAVILYWVFNMYMSDRVLRAAMDAKSCHHPHVQAAAD KIFRSAGISHVRIYETESDDYNGMAVGMNVGRSMVILTSATLTLPQRVIEGILAHEAI HIKKRDVLSSQLLRFLYLGAVVGIFLLFEQHITHPEAHKIALWAFIMAIIILFQLYQS FCSQWMEVRADNLGASLLDGGYKQMAEALRILAVRQDEDIQKQSAYSSEAGEDELQID SLTRDKSWFFRLIDFQFAPHPPMYWRVGTLLSNKGHGVLKRWLRDRLKESITLK*" /label="yxkI CDS" gene 3342021..3343709 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /label="yxkI gene" promotor_-35 3343707..3343716 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3343728..3343743 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3343732 /Source="Nicolas_upshifts" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="upshifts" CDS 3343767..3343967 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391758.1" /db_xref="EnsemblGenomes-Gn:BSU38790" /db_xref="EnsemblGenomes-Tr:CAB15905" /db_xref="SubtiList:BG14168" /db_xref="UniProtKB/Swiss-Prot:O32284" /translation="MIVIILLFISIIVFLSVIQPQPSKNKSRQQADSGYFGYSDHSSH HDGCSSDGGFSDSGCGGGGGGD*" /label="yxzE CDS" gene 3343767..3343967 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /label="yxzE gene" S_feature 3343968..3344912 /Source="Nicolas_S_feature" /locus_tag="new_3983174_3984118" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T0.0H, T-0.40H, Salt, T3.30H, T3.0H" /AntisenseName="yxkH" /AntisenseCor="0.147753218660366" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1489" CDS complement(3343981..3344820) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported polysaccharide deacetylase, lipoprotein" /protein_id="NP_391759.1" /db_xref="EnsemblGenomes-Gn:BSU38800" /db_xref="EnsemblGenomes-Tr:CAB15906" /db_xref="GOA:P94361" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG12544" /db_xref="UniProtKB/Swiss-Prot:P94361" /translation="MKRLFLSIFLLGSCLALAACADQEANAEQPMPKAEQKKPEKKAV QVQKKEDDTSAWIKTEKPAKLPILMYHSISSGNSLRVPKKEFEAHMKWLHDNGYQTLT PKEASLMLTQDKKPSEKCVLITFDDGYTDNYQDAYPVLKKYGMKATIFMIGKSIGHKH HLTEEQMKEMAQHGISIESHTIDHLELNGLTPQQQQSEMADSKKLFDNMFHQQTTIIS YPVGRYNEETLKAAEKTGYQMGVTTEPGAASRDQGMYALHRVRVSPGMSGSAFGAYIE SMK*" /label="yxkH CDS" gene complement(3343981..3344820) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /label="yxkH gene" promotor_-10 complement(3344846..3344864) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3344864) /Source="Nicolas_upshifts" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3344877..3344884) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3344879 /Source="Nicolas_upshifts" /id="D2010" /incds=0 /nref=27 /ntot=142 /MaxReadThrough="0.40982" /MaxDrop="6.50242" /score="33.6694147" /energy="-13.4" /TU="NA" /idTUdmin="U3055" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(3344927..3346024) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multiple sugar (maltodextrins) transporter ATP-binding protein" /protein_id="NP_391760.1" /db_xref="EnsemblGenomes-Gn:BSU38810" /db_xref="EnsemblGenomes-Tr:CAB15907" /db_xref="GOA:P94360" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005116" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11954" /db_xref="UniProtKB/Swiss-Prot:P94360" /translation="MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKS TTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLK LRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDE PLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGT PKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIG KEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDA RLDIQSGDELTVAFDMNKGHFFDSETEVRIR*" /label="msmX CDS" gene complement(3344927..3346024) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /label="msmX gene" downshifts complement(3344928) /Source="Nicolas_upshifts" /id="D2011" /incds=0 /nref=81 /ntot=171 /MaxReadThrough="3.31232" /MaxDrop="7.04855" /score="29.2689404" /energy="-14.4" /TU="U3057" /idTUdmin="U3058" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3346057..3346076) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3346074) /Source="Nicolas_upshifts" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3346076..3346144) /Source="Nicolas_S_feature" /locus_tag="new_3985282_3985350_c" /HighExp="M0t90, M40t90, Lbstat, Lbtran, T2.0H, dia5, T2.30H, M9-stat, S2, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1490" promotor_-35 complement(3346089..3346096) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3346145..3347038) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10746760" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10746760; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates yxkF-msmX expression)" /protein_id="NP_391761.1" /db_xref="EnsemblGenomes-Gn:BSU38820" /db_xref="EnsemblGenomes-Tr:CAB15908" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12543" /db_xref="UniProtKB/Swiss-Prot:P94359" /translation="MKSLLAIYPGSIVSEELCIREGCLCFFDESNQRYISIPKTEISE KEVLVLQSFLTPADEGNQLSMKSPEENKWFSFLFSRGELPAYIKKRTRFVHFHLFGKI ERTSFTEAVRHFWPVSFVIVWIHEDRGVIVEQESEAAAEKDELESLAKVLESDFYFSV RFYAGRFYEPDECLRKHYAREQAYFLFAEKRLPQVQSVTFEMIFPFLLLETEKEKLET LLSEEAELLFGSESELRKTIKLFIENNSNVTLTAKKLHLHRNSLQYRIDKFIERSGID IKSYKGALLAYFICLQNESSE*" /label="yxkF CDS" gene complement(3346145..3347038) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /label="yxkF gene" promotor_-10 complement(3347065..3347084) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3347084) /Source="Nicolas_upshifts" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3347098..3347105) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3347112..3347117 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3347133..3347151 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3347142 /Source="Nicolas_upshifts" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3347159..3347165 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3347180..3347198 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3347186 /Source="Nicolas_upshifts" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="upshifts" CDS 3347222..3348679 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391762.1" /db_xref="EnsemblGenomes-Gn:BSU38830" /db_xref="EnsemblGenomes-Tr:CAB15909" /db_xref="GOA:P94358" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="PDB:4DNG" /db_xref="SubtiList:BG11903" /db_xref="UniProtKB/Swiss-Prot:P94358" /translation="MSFETLNKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGK QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKST IELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLS MRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGM LTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAI FGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQ IEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKA GSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGG NKASGVGRFGNPWVVEEFTVTKWISIQKQYRKYPF*" /label="aldY CDS" gene 3347222..3348679 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /label="aldY gene" promotor_-10 complement(3348105..3348123) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3348120) /Source="Nicolas_upshifts" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3348138..3348143) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3348660 /Source="Nicolas_upshifts" /id="D2012" /incds=0 /nref=14 /ntot=39 /MaxReadThrough="1.43471" /MaxDrop="4.03346" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 3348704 /Source="Nicolas_upshifts" /id="D2013" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="1.40793" /MaxDrop="3.07407" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3348721..3349557) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10735877, 10931887, 15096624, 15849754, 16850406, 21317561; Product type t : transporter" /codon_start=1 /transl_table=11 /product="guanidinium exporter" /protein_id="NP_391763.1" /db_xref="EnsemblGenomes-Gn:BSU38840" /db_xref="EnsemblGenomes-Tr:CAB15910" /db_xref="GOA:P94357" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12542" /db_xref="UniProtKB/Swiss-Prot:P94357" /translation="MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILY YLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDEL IINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSS YFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGV TILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDI SK*" /label="gdnE CDS" gene complement(3348721..3349557) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /label="gdnE gene" downshifts complement(3348739) /Source="Nicolas_upshifts" /id="D2014" /incds=0 /nref=19 /ntot=137 /MaxReadThrough="1.00689" /MaxDrop="4.07213" /score="21.5028874" /energy="-13.8" /TU="NA" /idTUdmin="U3062" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" misc_RNA complement(3349634..3349736) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /product="guanidine riboswitch (type I)" /experiment="publication(s) with functional evidences, PMID:21317561, 27989440, 28096518" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21317561, 27989440, 28096518" /label="gdwB RNA" gene complement(3349634..3349736) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /label="gdwB gene" downshifts complement(3349660) /Source="Nicolas_upshifts" /id="D2015" /incds=0 /nref=194 /ntot=247 /MaxReadThrough="3.21415" /MaxDrop="5.58394" /score="-0.190335837" /energy="-10.7" /TU="U3062" /idTUdmin="U3065" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3349762..3349781) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3349773) /Source="Nicolas_upshifts" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3349775..3350516) /Source="Nicolas_S_feature" /locus_tag="new_3988981_3989722_c" /HighExp="S6, S8, S7, C30, S5, Gly, C90, Fru, BT, Pyr" /AntisenseName="yxkC" /AntisenseCor="-0.38162570069976298" /AntisenseRegPval="-10" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1491" promotor_-35 complement(3349795..3349801) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3349853..3349860 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3349873..3349891 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3349882 /Source="Nicolas_upshifts" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" S_feature 3349892..3349977 /Source="Nicolas_S_feature" /locus_tag="new_3989098_3989183" /HighExp="Cold, SMM, MG 150, GM 90, Glu, C30, GM 150, GM-0.2, GM 15, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1492" promotor_-35 3349953..3349960 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3349974..3349993 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3349979 /Source="Nicolas_upshifts" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" CDS 3350125..3350667 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818, 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391764.2" /db_xref="EnsemblGenomes-Gn:BSU38850" /db_xref="EnsemblGenomes-Tr:CAB15911" /db_xref="GOA:P94356" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12541" /db_xref="UniProtKB/Swiss-Prot:P94356" /translation="MRHKIITFILAVVVIIIIGNMIGGGGGSEATSKTSSSSKAETEK TYNIGDTVKTEKTEVTVTKVEDRDTVGTQYVEKKASEGGTIVAVQYTIKNVSKKPISS FSIPTVKLVDADGTSYDSDIDASVNYATETKVDNSKILSDLNPNIKVTGVKAFEVDKE AYAKGTWKLKFSNDVIVKIK*" /label="yxkC CDS" gene 3350125..3350667 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /label="yxkC gene" promotor_-10 complement(3350492..3350511) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3350516) /Source="Nicolas_upshifts" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3350525..3350534) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3350657 /Source="Nicolas_upshifts" /id="D2016" /incds=0 /nref=78 /ntot=276 /MaxReadThrough="4.33141" /MaxDrop="6.78221" /score="9.28209494" /energy="-14.4" /TU="U3063,U3064" /idTUdmin="U3064" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" S_feature 3350702..3351024 /Source="Nicolas_S_feature" /locus_tag="new_3989908_3990230" /HighExp="Cold, C30, Heat, Fru, Glu, C90, BMM, Glucon, M/G, Mal" /AntisenseName="galE" /AntisenseCor="0.165797390333391" /AntisenseRegPval="-2.2000000000000002" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1493" CDS complement(3350742..3351761) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /EC_number="5.1.3.7" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1906927, 9555917, 14597172" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906927, 9555917, 14597172; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase" /protein_id="NP_391765.1" /db_xref="EnsemblGenomes-Gn:BSU38860" /db_xref="EnsemblGenomes-Tr:CAB15912" /db_xref="GOA:P55180" /db_xref="InterPro:IPR005886" /db_xref="InterPro:IPR008089" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11837" /db_xref="UniProtKB/Swiss-Prot:P55180" /translation="MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRV KEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLT GTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFG NDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFE KVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNG YKSAE*" /label="galE CDS" gene complement(3350742..3351761) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /label="galE gene" downshifts complement(3350760) /Source="Nicolas_upshifts" /id="D2017" /incds=0 /nref=235 /ntot=261 /MaxReadThrough="1.7919" /MaxDrop="7.32805" /score="24.6899971" /energy="-14.8" /TU="NA" /idTUdmin="U3066" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3351787..3351806) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3351801) /Source="Nicolas_upshifts" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3351821..3351824) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3351876..3352382) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phospholipid binding protein" /protein_id="NP_391766.1" /db_xref="EnsemblGenomes-Gn:BSU38870" /db_xref="EnsemblGenomes-Tr:CAB15913" /db_xref="InterPro:IPR005247" /db_xref="InterPro:IPR008914" /db_xref="InterPro:IPR036610" /db_xref="SubtiList:BG11899" /db_xref="UniProtKB/Swiss-Prot:P55185" /translation="MNIYVEANPYLHDKYSKYADEKYKREGNPFVSFPIHFDDIPSGA KTLALTFIDHDAIPVCGFSWIHWTAANIPAYIGELPEHASEERQDLMIQGQNSFASPL AGSNDPKVIHQYCGPTPPDKDHAYTLTVYALDAELNLQPGFYLNELYQEMKEHILAET SIELLARV*" /label="yxkA CDS" gene complement(3351876..3352382) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /label="yxkA gene" promotor_-10 complement(3352388..3352407) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3352410) /Source="Nicolas_upshifts" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3352412..3352415 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3352421..3352427) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3352430..3352449 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3352433 /Source="Nicolas_upshifts" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="upshifts" CDS 3352512..3353387 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391767.1" /db_xref="EnsemblGenomes-Gn:BSU38880" /db_xref="EnsemblGenomes-Tr:CAB15914" /db_xref="GOA:P55181" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11898" /db_xref="UniProtKB/Swiss-Prot:P55181" /translation="MDLKWLQTFIAAAESESFREAAEHLYLTQPAVSQHMRKLEDELD MRLFLHSGRRVVLTDEGRLFLPYAKEMIHVYQAGKQKVSQWKQGYSRSLTLAVHPYIA SYILPRFLPAYIQKHPHVELSTHVAGSDAIKQAVEHNEADIGLSRKDPNTNTLYYQHI CEGTLCLAAPFQESRPDAASVLTRYRLLTHDHPSYGDAFLDNIRSHYPYLQMMAVGQT DTAVHMMKAGMGASFLPTYIIKQEEAEKKLMAVSTPAHLELPASQTFMMWKRNSEDIQ HFHAMLHDFMQREQV*" /label="yxjO CDS" gene 3352512..3353387 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /label="yxjO gene" S_feature complement(3352762..3352850) /Source="Nicolas_S_feature" /locus_tag="new_3991968_3992056_c" /HighExp="GM 60, MG-0.1, MG 10, GM 5, S8, T0.30H, BC, S6, GM 15, GM 150" /AntisenseName="yxjO" /AntisenseCor="0.14032494397598999" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0669" /TUlongSig="NA" /TUlongPSig="NA" /label="S1494" downshifts complement(3352784) /Source="Nicolas_upshifts" /id="D2018" /incds=1 /nref=22 /ntot=45 /MaxReadThrough="0.10815" /MaxDrop="6.05884" /score="5.06408541" /energy="-5.6" /TU="NA" /idTUdmin="U3069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3352810..3352910) /Source="Nicolas_upshift_promotors" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3352850) /Source="Nicolas_upshifts" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="upshifts" CDS 3353465..3353938 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391768.1" /db_xref="EnsemblGenomes-Gn:BSU38890" /db_xref="EnsemblGenomes-Tr:CAB15915" /db_xref="GOA:P55182" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR020223" /db_xref="SubtiList:BG11897" /db_xref="UniProtKB/Swiss-Prot:P55182" /translation="MAMSPYIFIVLILIILSMYRERTVKPGKLLIIPLLLLWGVSASF QPAYFHSVLHVAISGILLLIGLACGFGIGKMVNVRIHPETGKVTSRGSLGSVILILVI LSLRMAARTWLPESNEMFIAIIHSMFFVPLGTITARNIMLYKAYRRLTAGKVSIQ*" /label="yxjN CDS" gene 3353465..3353938 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /label="yxjN gene" CDS 3353956..3355176 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxjL]" /protein_id="NP_391769.1" /db_xref="EnsemblGenomes-Gn:BSU38900" /db_xref="EnsemblGenomes-Tr:CAB15916" /db_xref="GOA:P55183" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11896" /db_xref="UniProtKB/Swiss-Prot:P55183" /translation="MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFA VYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRL PSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAE RNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHEL TSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTAL RGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAV ISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSL PLMTTNKEQKDEQR*" /label="yxjM CDS" gene 3353956..3355176 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /label="yxjM gene" CDS 3355163..3355819 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YxjM]" /protein_id="NP_391770.1" /db_xref="EnsemblGenomes-Gn:BSU38910" /db_xref="EnsemblGenomes-Tr:CAB15917" /db_xref="GOA:P55184" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11895" /db_xref="UniProtKB/Swiss-Prot:P55184" /translation="MNKDKIRVALADDQPLVREGFRYVINAQTDMTVSGEAGDGHDII ALAKQTKPDVILMDVQMPRCSGIEAAKDIMSALPNTKIVILTTFDTEEYVFEGIRAGA VGYLLKDTLPEELIDAIRAAARGEAIFRTVTAAKIISETFRAKQQTHAEELAEPFTKR ELEVLQQMAYGLRNEDIAEKLFVSESTVKTHVHRILQKCNAQDRTQAVVFAIRNGIVQ *" /label="yxjL CDS" gene 3355163..3355819 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /label="yxjL gene" promotor_-35 3355817..3355822 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3355836..3355855 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3355839 /Source="Nicolas_upshifts" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="upshifts" CDS 3355869..3357101 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /EC_number="3.4.11.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8978088, 10987140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8978088, 10987140; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase T (tripeptidase)" /protein_id="NP_391771.1" /db_xref="EnsemblGenomes-Gn:BSU38920" /db_xref="EnsemblGenomes-Tr:CAB15918" /db_xref="GOA:P55179" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010161" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11842" /db_xref="UniProtKB/Swiss-Prot:P55179" /translation="MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELK SIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGK DIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKH PEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKI TIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEET KLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEI VNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNM VKAVNVIVEIAKQFEAQA*" /label="pepT CDS" gene 3355869..3357101 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /label="pepT gene" downshifts complement(3355886) /Source="Nicolas_upshifts" /id="D2019" /incds=0 /nref=4 /ntot=116 /MaxReadThrough="0.86167" /MaxDrop="3.19485" /score="-2.15704435" /energy="-9.1" /TU="NA" /idTUdmin="U3069" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" downshifts 3357086 /Source="Nicolas_upshifts" /id="D2020" /incds=0 /nref=203 /ntot=244 /MaxReadThrough="3.3949" /MaxDrop="6.35116" /score="27.2051031" /energy="-13.5" /TU="U3070" /idTUdmin="U3070" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 3357147..3357156 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3357169..3357184 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3357171..3357393 /Source="Nicolas_S_feature" /locus_tag="new_3996377_3996599" /HighExp="T-0.40H, T0.30H, T0.0H, T-1.40H, T1.0H, T-1.10H, T3.30H, T2.0H, T1.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80396299999999998" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1495" upshifts 3357171 /Source="Nicolas_upshifts" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3357350 /Source="Nicolas_upshifts" /id="D2021" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="4.83682" /MaxDrop="4.66302" /score="-1.57383757" /energy="-6.2" /TU="U3071" /idTUdmin="U3070" /TUdmin=242 /isTUend="FALSE" /label="downshifts" promotor_-35 3357404..3357410 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-35" S_feature 3357423..3357523 /Source="Nicolas_S_feature" /locus_tag="new_3996629_3996729" /HighExp="Etha, Gly, Sw, Salt, B60, T0.30H, LoTm, M9-stat, T1.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1496" upshifts 3357423 /Source="Nicolas_upshifts" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="upshifts" promotor_-10 3357425..3357443 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-10" promotor_-35 3357502..3357509 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3357523..3357541 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3357525..3357622 /Source="Nicolas_S_feature" /locus_tag="new_3996731_3996828" /HighExp="Etha, T0.30H, Gly, T1.0H, Sw, Salt, T1.30H, GM 15, B60, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1497" upshifts 3357525 /Source="Nicolas_upshifts" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" CDS 3357623..3357886 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391772.1" /db_xref="EnsemblGenomes-Gn:BSU38930" /db_xref="EnsemblGenomes-Tr:CAB15919" /db_xref="GOA:P94353" /db_xref="SubtiList:BG12540" /db_xref="UniProtKB/Swiss-Prot:P94353" /translation="MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYL LFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS*" /label="yxjJ CDS" gene 3357623..3357886 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /label="yxjJ gene" promotor_-35 3357650..3357653 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3357668..3357687 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" upshifts 3357680 /Source="Nicolas_upshifts" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3357834 /Source="Nicolas_upshifts" /id="D2022" /incds=0 /nref=4 /ntot=92 /MaxReadThrough="7.33654" /MaxDrop="3.1638" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3357878 /Source="Nicolas_upshifts" /id="D2023" /incds=0 /nref=44 /ntot=188 /MaxReadThrough="5.58502" /MaxDrop="4.5161" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 3357953..3357962 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3357968 /Source="Nicolas_upshifts" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3357974..3357989 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3358015..3358503 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391773.1" /db_xref="EnsemblGenomes-Gn:BSU38940" /db_xref="EnsemblGenomes-Tr:CAB15920" /db_xref="InterPro:IPR007612" /db_xref="InterPro:IPR025659" /db_xref="SubtiList:BG12539" /db_xref="UniProtKB/Swiss-Prot:P94352" /translation="MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMT DSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLW RDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDES IF*" /label="yxjI CDS" gene 3358015..3358503 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /label="yxjI gene" promotor_-35 3358508..3358515 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3358529..3358548 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3358539 /Source="Nicolas_upshifts" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3358569..3358675 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswI RNA" gene 3358569..3358675 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /label="mswI gene" downshifts 3358670 /Source="Nicolas_upshifts" /id="D2024" /incds=0 /nref=22 /ntot=102 /MaxReadThrough="7.18775" /MaxDrop="3.7896" /score="9.64734237" /energy="-14.5" /TU="U3075,U3076" /idTUdmin="U3072" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3358758..3359891 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyl-tetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391774.2" /db_xref="EnsemblGenomes-Gn:BSU38950" /db_xref="EnsemblGenomes-Tr:CAB15921" /db_xref="GOA:P42319" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11157" /db_xref="UniProtKB/Swiss-Prot:P42319" /translation="MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAG EMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAE GIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEK ADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALG GDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLN LDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFV SLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR*" /label="yxjH CDS" gene 3358758..3359891 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /label="yxjH gene" S_feature complement(3359031..3359274) /Source="Nicolas_S_feature" /locus_tag="new_3998237_3998480_c" /HighExp="dia15, Diami, H2O2, dia5, C90, Paraq, Sw, BC, LBGstat, Lbtran" /AntisenseName="yxjH" /AntisenseCor="-0.34694665046491102" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1498" promotor_-10 complement(3359269..3359288) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3359278) /Source="Nicolas_upshifts" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3359303..3359310) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3359897..3359904 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3359919..3359938 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3359925 /Source="Nicolas_upshifts" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3359960..3360066 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswJ RNA" gene 3359960..3360066 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /label="mswJ gene" downshifts 3360013 /Source="Nicolas_upshifts" /id="D2025" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="8.35488" /MaxDrop="3.50346" /score="29.0146782" /energy="-14.5" /TU="U3075,U3076,U3078" /idTUdmin="U3075" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 3360067..3360143 /Source="Nicolas_S_feature" /locus_tag="new_3999273_3999349" /HighExp="MG 5, MG t5, T1.0H, MG 10, T1.30H, BMM, T0.30H, T-0.40H, T0.0H, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigD, SigB, SigWXY" /TUlongPSig="0.554, 1, 1, 1" /label="S1499" CDS 3360144..3361280 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254, 21749987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391775.3" /db_xref="EnsemblGenomes-Gn:BSU38960" /db_xref="EnsemblGenomes-Tr:CAB15922" /db_xref="GOA:P42318" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11156" /db_xref="UniProtKB/Swiss-Prot:P42318" /translation="MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAG EMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQ GIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGK LEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAF GTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGL NLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRY VSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK*" /label="yxjG CDS" gene 3360144..3361280 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /label="yxjG gene" downshifts 3361267 /Source="Nicolas_upshifts" /id="D2026" /incds=0 /nref=81 /ntot=187 /MaxReadThrough="4.24668" /MaxDrop="5.8124" /score="11.1243305" /energy="-12.8" /TU="U3076,U3078" /idTUdmin="U3075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3361333..3362106) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacid dehydrogenase" /protein_id="NP_391776.2" /db_xref="EnsemblGenomes-Gn:BSU38970" /db_xref="EnsemblGenomes-Tr:CAB15923" /db_xref="GOA:P42317" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011294" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11155" /db_xref="UniProtKB/Swiss-Prot:P42317" /translation="MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAA SKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTD TFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVI GLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVP QKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ*" /label="yxjF CDS" gene complement(3361333..3362106) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /label="yxjF gene" downshifts complement(3361343) /Source="Nicolas_upshifts" /id="D2027" /incds=0 /nref=23 /ntot=63 /MaxReadThrough="0.65" /MaxDrop="6.97604" /score="24.6585594" /energy="-12.8" /TU="NA" /idTUdmin="U3079" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3362123..3362773) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit B)" /protein_id="NP_391777.1" /db_xref="EnsemblGenomes-Gn:BSU38980" /db_xref="EnsemblGenomes-Tr:CAB15924" /db_xref="GOA:P42316" /db_xref="InterPro:IPR004164" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11154" /db_xref="UniProtKB/Swiss-Prot:P42316" /translation="MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVML QSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAIL GGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSL PLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS*" /label="scoB CDS" gene complement(3362123..3362773) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /label="scoB gene" CDS complement(3362770..3363486) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit A)" /protein_id="NP_391778.1" /db_xref="EnsemblGenomes-Gn:BSU38990" /db_xref="EnsemblGenomes-Tr:CAB15925" /db_xref="GOA:P42315" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11153" /db_xref="UniProtKB/Swiss-Prot:P42315" /translation="MGKVLSSSKEAAKLIHDGDTLIAGGFGLCGIPEQLILSIRDQGV KDLTVVSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGT LAERIRAGGAGIPGFYTATGVGTSIAEGKEHKTFGGRTYVLERGITGDVAIVKAWKAD TMGNLIFRKTARNFNPIAAMAGKITIAEAEEIVEAGELDPDHIHTPGIYVQHVVLGAS QEKRIEKRTVQQASGKGEAK*" /label="scoA CDS" gene complement(3362770..3363486) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /label="scoA gene" CDS complement(3363510..3364928) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative acid metabolite permease" /protein_id="NP_391779.3" /db_xref="EnsemblGenomes-Gn:BSU39000" /db_xref="EnsemblGenomes-Tr:CAB15926" /db_xref="GOA:P42314" /db_xref="SubtiList:BG11152" /db_xref="UniProtKB/Swiss-Prot:P42314" /translation="MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVL PFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAI VLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGT PQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQ NAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLK EFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTG AEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAM SEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFA ITLIKTAAVFAVIAIYSLTGLV*" /label="yxjC CDS" gene complement(3363510..3364928) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /label="yxjC gene" promotor_-10 complement(3364096..3364114) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3364115) /Source="Nicolas_upshifts" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3364130..3364135) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3364929..3365013) /Source="Nicolas_S_feature" /locus_tag="new_4004135_4004219_c" /HighExp="S5, S4, S6, S3, S7, M9-stat, B60, S8, T4.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1500" promotor_-10 complement(3364997..3365015) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3365013) /Source="Nicolas_upshifts" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3365031..3365036) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3365082..3365930) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /EC_number="2.1.1.188" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11967079, 14999102, 18406425, 23716046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m(1)G748 methyltransferase (class II)" /protein_id="NP_391780.1" /db_xref="EnsemblGenomes-Gn:BSU39010" /db_xref="EnsemblGenomes-Tr:CAB15927" /db_xref="GOA:P42313" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR016718" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11151" /db_xref="UniProtKB/Swiss-Prot:P42313" /translation="MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYV NFLTKPVKTSYGAELFEARSRLIGECGFFDPLHDAIAELISHPKSGHEAFTILDSGCG EGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVARAPFHDRQFD VVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVER FTANAAHSRPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVD ILIGMK*" /label="rlmA CDS" gene complement(3365082..3365930) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /label="rlmA gene" downshifts complement(3365092) /Source="Nicolas_upshifts" /id="D2028" /incds=0 /nref=54 /ntot=218 /MaxReadThrough="1.618" /MaxDrop="4.63737" /score="17.0758624" /energy="-15.1" /TU="NA" /idTUdmin="U3081" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(3365931..3366116) /Source="Nicolas_S_feature" /locus_tag="new_4005137_4005322_c" /HighExp="B60, LBGstat, LPhT, M9-stat, C30, T0.30H, HPh, Oxctl, Heat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1501" promotor_-10 complement(3366105..3366124) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3366116) /Source="Nicolas_upshifts" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3366118..3366843) /Source="Nicolas_S_feature" /locus_tag="new_4005324_4006049_c" /HighExp="LBGstat, C30, GM 25, Heat, GM 10, GM 45, GM 60, GM 90, T0.30H, GM 120" /AntisenseName="NA" /AntisenseCor="0.20859849915331599" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1502" promotor_-35 complement(3366140..3366144) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3366278..3366285 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3366298..3366317 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3366307 /Source="Nicolas_upshifts" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3366317..3366419 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswB RNA" gene 3366317..3366419 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /label="gswB gene" S_feature 3366420..3366523 /Source="Nicolas_S_feature" /locus_tag="new_4005626_4005729" /HighExp="C90, G180, M40t45, dia15, LBGexp, Lbexp, Lbtran, G135, Mt0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1503" promotor_-35 3366495..3366501 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3366515..3366526 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3366525 /Source="Nicolas_upshifts" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="upshifts" CDS 3366546..3367739 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12787499, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="purine nucleoside transporter" /protein_id="NP_391781.2" /db_xref="EnsemblGenomes-Gn:BSU39020" /db_xref="EnsemblGenomes-Tr:CAB15928" /db_xref="GOA:P42312" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG11150" /db_xref="UniProtKB/Swiss-Prot:P42312" /translation="MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITW FMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVT FFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVL SNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPE DEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHG LTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHT VAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIV GLFVW*" /label="nupG CDS" gene 3366546..3367739 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /label="nupG gene" promotor_-10 complement(3366830..3366848) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3366846) /Source="Nicolas_upshifts" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3366861..3366868) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3367515 /Source="Nicolas_upshifts" /id="D2029" /incds=1 /nref=1 /ntot=58 /MaxReadThrough="5.88279" /MaxDrop="2.4159" /score="8.04757856" /energy="-16.6" /TU="U3082,U3083" /idTUdmin="U3082" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" downshifts 3367735 /Source="Nicolas_upshifts" /id="D2030" /incds=0 /nref=71 /ntot=204 /MaxReadThrough="2.7474" /MaxDrop="4.05925" /score="8.04757856" /energy="-16.6" /TU="NA" /idTUdmin="U3082" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3367781..3368209) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminus)" /translation="KTKKQANSRALKREYQTSFSVKYNAAGKLSIQTLNYIYSGGAHG LTSVQSFNYDLKAQKRVTLDQILNTKTKVSKTRDYLYSYIKKHDVLFFSDVKKEDITL NRDTMFYFTANGIAIVFGQYDLGPYAAGIRDVQVPASIYQ*" /label="yxiTc CDS" gene complement(3367781..3368209) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /pseudo /label="yxiTc gene" CDS complement(3368210..3368452) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (N-terminus)" /db_xref="PSEUDO:CAB15929.2" /db_xref="SubtiList:BG11149" /db_xref="UniProtKB/Swiss-Prot:P42311" /translation="MKWNNMLKAAGIAVLLFSVFAYAAPSLKAVQAKTPTVSTHTYKK IKELTYPQVHHVGNAAFEKKINQELKAYMNNRIRNT*" /label="yxiTn CDS" gene complement(3368210..3368452) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /pseudo /label="yxiTn gene" S_feature complement(3368453..3368516) /Source="Nicolas_S_feature" /locus_tag="new_4007659_4007722_c" /HighExp="T2.30H, S6, Etha, T3.30H, S5, BT, T3.0H, T4.0H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.942" /TUlongSig="NA" /TUlongPSig="NA" /label="S1504" promotor_-10 complement(3368505..3368520) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3368516) /Source="Nicolas_upshifts" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3368532..3368541) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3368549 /Source="Nicolas_upshifts" /id="D2031" /incds=0 /nref=10 /ntot=69 /MaxReadThrough="0.814549999999999" /MaxDrop="3.89525" /score="14.5338714" /energy="-6.9" /TU="NA" /idTUdmin="U3082" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(3368597..3368887) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391783.2" /db_xref="EnsemblGenomes-Gn:BSU39040" /db_xref="EnsemblGenomes-Tr:CAB15930" /db_xref="SubtiList:BG11148" /db_xref="UniProtKB/Swiss-Prot:P42310" /translation="MNEKQLTEAYERDENMMILVFAQWCVNHDLDPMELYAKAYPQQK LNESLKKTMDDLVVPKHEAEHIPDQTVIAVLEMFGNTDLAQALHEAISGRKQ*" /label="yxiS CDS" gene complement(3368597..3368887) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /label="yxiS gene" downshifts complement(3368603) /Source="Nicolas_upshifts" /id="D2032" /incds=0 /nref=168 /ntot=241 /MaxReadThrough="3.10756" /MaxDrop="6.10709" /score="16.5130207" /energy="-6.9" /TU="NA" /idTUdmin="U3086" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3368912..3368931) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3368929) /Source="Nicolas_upshifts" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3368937..3370997) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7559348, 8931328, 16151211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559348, 8931328, 16151211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catalase 2" /protein_id="NP_391784.2" /db_xref="EnsemblGenomes-Gn:BSU39050" /db_xref="EnsemblGenomes-Tr:CAB15931" /db_xref="GOA:P42234" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024712" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11102" /db_xref="UniProtKB/Swiss-Prot:P42234" /translation="MSDDQNKRVNEHSKDEQLEQYRTDNSGKKMTTNQGLRVSEDEHS LKAGVRGPTLMEDFHFREKMTHFDHERIPERVVHARGFGVHGFFQVYEPMTEYTRAKF LQDPSVKTPVFVRFSTVAGSKGSADTVRDARGFATKFYTEEGNYDLVGNNIPVFFIQD AIKFPDLVHAFKPEPHNEMPQAATAHDTFWDFVANNPESAHMVMWTMSDRGIPRSYRM MEGFGVHTFRFVNEQGKARFVKFHWKPVLGVHSLVWDEAQKIAGKDPDFHRRDLWETI ENGGKVEYELGVQMIDEEDEFKFDFDILDPTKLWPEELVPVKIIGKMTLNRNQDNVFA ETEQVAFHPGNVVPGIDFTNDPLLQGRLFSYTDTQLIRLGGPNFHEIPINRPVCPFHN NQYDGYHRMTINKGPVAYHKNSLQNNDPSPATAEEGGYVHYQEKVEGKKIRQRSDSFN DYYSQAKLFWNSMSPVEKQHIISAFCFEVGKVKSKDVQRQVVDVFSNVDADLAEEIAK GVGVAAPAKRKASKEILTSPALSQARTVKTASTRKVAVLAGNGFHEKELQTVLEALKQ EGITVDIISQNLGYMTSGSGQQLEASGTFLTVDSVLYDAVYAAGGLELKDNKQAMAFI REAYNHYKAIGAANEGIDLLQSSVGTTEGLGIVTAKDEPDYTAFSKAFIDAVAAHRHW DRRI*" /label="katE CDS" gene complement(3368937..3370997) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /label="katE gene" promotor_-35 complement(3368945..3368952) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3371026..3371044) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3371030) /Source="Nicolas_upshifts" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3371059..3371065) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3371090..3371095 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3371109 /Source="Nicolas_upshifts" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3371111..3371129 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3371123..3371197 /Source="Nicolas_S_feature" /locus_tag="new_4010329_4010403" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, LoTm, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1505" CDS 3371198..3372478 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8892821, 11053381, 15849754, 16850406, 18556792" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8892821, 11053381, 15849754, 16850406, 18556792; Product type t : transporter" /codon_start=1 /transl_table=11 /product="secondary transporter of divalent metal ions/citrate complexes" /protein_id="NP_391785.2" /db_xref="EnsemblGenomes-Gn:BSU39060" /db_xref="EnsemblGenomes-Tr:CAB15932" /db_xref="GOA:P42308" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11146" /db_xref="UniProtKB/Swiss-Prot:P42308" /translation="MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKD LGEMMIQGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPLKIAVGTA VLTMTISLDGDGTTTYMITIAAMLPLYKRLGMNRLVLAGIAMLGSGVMNIIPWGGPTA RVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEA APLKRPALQWFNLLLTVALMAALITSLLPLPVLFMTAFAVALMVNYPNVKEQQKRISA HAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSLVSLIPDAMGPHLPLITAIVSMPF TFFMSNDAFYFGVLPIIAEAASAYGIDAAEIGRASLLGQPVHLLSPLVPSTYLLVGMA GVSFGDHQKFTIKWAVGTTIVMTIAALLIGIISF*" /label="citH CDS" gene 3371198..3372478 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /label="citH gene" S_feature 3372479..3372618 /Source="Nicolas_S_feature" /locus_tag="new_4011685_4011824" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, BT, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.382965" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1506" downshifts 3372575 /Source="Nicolas_upshifts" /id="D2033" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.69139" /MaxDrop="3.50434" /score="10.8797157" /energy="-9" /TU="NA" /idTUdmin="U3088" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3372636..3373364) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /EC_number="3.2.1.73" /EC_number="3.2.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1369198, 3106158, 7704256, 20600285, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1369198, 3106158, 7704256, 20600285, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,3-1,4 glucanase" /protein_id="NP_391786.1" /db_xref="EnsemblGenomes-Gn:BSU39070" /db_xref="EnsemblGenomes-Tr:CAB15943" /db_xref="GOA:P04957" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR008264" /db_xref="InterPro:IPR013320" /db_xref="PDB:3O5S" /db_xref="SubtiList:BG10476" /db_xref="UniProtKB/Swiss-Prot:P04957" /translation="MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSG FWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGL YEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEK IVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVD EWLGSYNGVNPLYAHYDWVRYTKK*" /label="bglS CDS" gene complement(3372636..3373364) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /label="bglS gene" downshifts complement(3372653) /Source="Nicolas_upshifts" /id="D2034" /incds=0 /nref=64 /ntot=139 /MaxReadThrough="1.52649" /MaxDrop="6.38109" /score="-8.35070051" /energy="-16.3" /TU="NA" /idTUdmin="U3089" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3373395..3373414) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3373406) /Source="Nicolas_upshifts" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3373428..3373435) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3373552..3373659) /Source="Nicolas_S_feature" /locus_tag="new_4012758_4012865_c" /HighExp="Sw, LPhT, T0.30H, M0t90, M9-stat, M40t90, Lbtran, Lbstat, S2, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1507" downshifts complement(3373595) /Source="Nicolas_upshifts" /id="D2035" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="3.35114" /MaxDrop="4.38508" /score="-8.35070051" /energy="-16.3" /TU="U3090,U3091" /idTUdmin="U3091" /TUdmin="-174" /isTUend="FALSE" /label="downshifts" CDS complement(3373660..3374493) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_391787.2" /db_xref="EnsemblGenomes-Gn:BSU39080" /db_xref="EnsemblGenomes-Tr:CAB15944" /db_xref="GOA:P39805" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1H99" /db_xref="PDB:1L1C" /db_xref="PDB:1TLV" /db_xref="SubtiList:BG10474" /db_xref="UniProtKB/Swiss-Prot:P39805" /translation="MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARI EKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHIN FAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHI VNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNG THMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQ A*" /label="licT CDS" gene complement(3373660..3374493) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /label="licT gene" promotor_-10 complement(3374524..3374543) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3374543) /Source="Nicolas_upshifts" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3374557..3374564) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3374589..3375269) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391788.1" /db_xref="EnsemblGenomes-Gn:BSU39090" /db_xref="EnsemblGenomes-Tr:CAB15945" /db_xref="SubtiList:BG11145" /db_xref="UniProtKB/Swiss-Prot:P42307" /translation="MRRIGLCISLLVTVLVMSACESEGEAQMFADCDQKTVKQTAAKP MSSKKKQDFQALASDRQLAIVFSSMIQVSEAFDYGIGNPEYFVRISMTEEEADIAKEN LESIKLENKSLKKQNSEAVALLQKTRNQDMSRIEIQQLTENRAGFFETADSMIKLINQ VTPKNAKKTRQQLDQLKKQYTQYSAESIKIMNSIVKKQKADKASFERHLEALLQKQPG QQVRSELY*" /label="yxiP CDS" gene complement(3374589..3375269) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /label="yxiP gene" promotor_-10 complement(3375316..3375335) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-10" upshifts complement(3375325) /Source="Nicolas_upshifts" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="upshifts" promotor_-35 complement(3375349..3375356) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-35" promotor_-35 3375417..3375420 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3375435..3375454 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3375435 /Source="Nicolas_upshifts" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="upshifts" CDS 3375476..3376762 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12583894, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391789.1" /db_xref="EnsemblGenomes-Gn:BSU39100" /db_xref="EnsemblGenomes-Tr:CAB15946" /db_xref="GOA:P42306" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11144" /db_xref="UniProtKB/Swiss-Prot:P42306" /translation="MMKRFTKQENSWVLYDWANSAYSIVVTTAVFPLFYKSAAAESGV SAAQSTAYLGYTIAISTFILAMLGPILGTIADYEGCKKKFFGFFVSAGVASTAMLAFI PSEHWLLLLLFYTVSAIGFSGANVFYDAFLVDVTPEKRMNLVSARGFGLGYIGSTIPF IISIAVILLAQAETIPVSVSAASQLSFFITAAWWGLFTIPMIKHVHQRYYIKKEPHIV INSFKRLGQTMKRIRQYRALFLFLLAYFFYIDGVGTIITMSTSYGSDLGIGSSSLLII LFVTQVVAAPFSIIYGKLAERFTGKTMLYVGIVIYMIVCVYAYFMETTLDFWILAMLV ATSQGGIQALSRSYFAKLVPKRHANEFFGFYNIFGKFASIMGPLLIAVTAQLTGKSST AVFSLIILFVIGIVILAFVPEETSTDVSQQQNDLPL*" /label="yxiO CDS" gene 3375476..3376762 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /label="yxiO gene" promotor_-10 complement(3376207..3376225) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3376215) /Source="Nicolas_upshifts" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3376239..3376246) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3376733 /Source="Nicolas_upshifts" /id="D2036" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="2.50578" /MaxDrop="3.06646" /score="-7.45683354" /energy="-16.7" /TU="NA" /idTUdmin="U3092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3376781..3378220) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase for 23S ribosomal RNAmaturation" /protein_id="NP_391790.2" /db_xref="EnsemblGenomes-Gn:BSU39110" /db_xref="EnsemblGenomes-Tr:CAB15947" /db_xref="GOA:P42305" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005580" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028619" /db_xref="PDB:2G0C" /db_xref="PDB:2HJV" /db_xref="PDB:3MOJ" /db_xref="SubtiList:BG11143" /db_xref="UniProtKB/Swiss-Prot:P42305" /translation="MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVV KSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKAT AVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMG FIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHA VIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQ EDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRA GNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESK KDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEI LNGKGPHVLKVMKNTTVKGKQLKVNKANK*" /label="deaD CDS" gene complement(3376781..3378220) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /label="deaD gene" downshifts complement(3376804) /Source="Nicolas_upshifts" /id="D2037" /incds=0 /nref=200 /ntot=269 /MaxReadThrough="1.50578" /MaxDrop="5.83238" /score="3.28924902" /energy="-18.2" /TU="NA" /idTUdmin="U3095" /TUdmin=5 /isTUend="TRUE" /label="downshifts" misc_feature complement(3378244..3378263) /Source="Nicolas_upshift_promotors" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3378261) /Source="Nicolas_upshifts" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3378302..3379450) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10746760, 25394512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="esterase (lipoprotein)" /protein_id="NP_391791.2" /db_xref="EnsemblGenomes-Gn:BSU39120" /db_xref="EnsemblGenomes-Tr:CAB15948" /db_xref="GOA:P42304" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="PDB:2O14" /db_xref="SubtiList:BG11142" /db_xref="UniProtKB/Swiss-Prot:P42304" /translation="MKKWMAAVFVMMLMLCFGGIENVKAAEPKVYQFDFGSGSMEPGY IGVRASDRYDRSKGYGFQTPENMRDVAASGAGVKSDAVQFLAYGTKSNNTFNVDLPNG LYEVKVTLGNTARASVAAEGVFQVINMTGDGAEDTFQIPVTDGQLNLLVTEGKAGTAF TLSALKIKKLSDQPVTNRTIYVGGDSTVCNYYPLNSSKQAGWGQMLPHYIDKHTFQVR NMASGGQIARGFRNDGQLEAILKYIKPGDYFMLQLGINDTNPKHKESEAEFKEVMRDM IRQVKAKGADVILSTPQGRATDFTSEGIHSSVNRWYRASILALAEEEKTYLIDLNVLS SAYFTSIGPERTLGLYMDGDTLHPNRAGADALARLAVQELKRQGIAGF*" /label="yxiM CDS" gene complement(3378302..3379450) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /label="yxiM gene" promotor_-10 complement(3379477..3379493) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3379493) /Source="Nicolas_upshifts" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3379495..3379579) /Source="Nicolas_S_feature" /locus_tag="new_4018701_4018785_c" /HighExp="T3.30H, T4.0H, T2.30H, T3.0H, T2.0H, T-3.40H, T5.0H, T-2.40H, Lbexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1508" promotor_-35 complement(3379508..3379513) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3379580..3379768) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52710.1" /translation="MRFENISASKLDDLESIDSVALEIVPTDDQWERLRYYVYDEENQ ISFYCGGWDVIKCDKKSH*" /label="yxzI CDS" gene complement(3379580..3379768) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /pseudo /label="yxzI gene" CDS complement(3379799..3379930) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097796.1" /db_xref="EnsemblGenomes-Gn:BSU39139" /db_xref="EnsemblGenomes-Tr:CAX52711" /db_xref="UniProtKB/Swiss-Prot:C0H3T5" /translation="MNITQYEKLKQHLSDEDTGPFTLNEFSFYMKEDDRYIHIPVFE* " /label="yxzJ CDS" gene complement(3379799..3379930) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /label="yxzJ gene" CDS complement(3379942..3380403) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391793.1" /db_xref="EnsemblGenomes-Gn:BSU39140" /db_xref="EnsemblGenomes-Tr:CAB15950" /db_xref="SubtiList:BG11140" /db_xref="UniProtKB/Swiss-Prot:P42302" /translation="MEITSISSIGNLDMIELKPDQTVMACELEDAESFYRFWAGLAYD RIMIQVITTGSFIEDLSEYFEGHAYKVTKLAKREFHFQSILQEADRDIADFLFLLASI NDDVFLITDPQPDKSYFSEGKLQCLTDSGERIIWFEYDAVDIYMIGGESYK*" /label="yxiK CDS" gene complement(3379942..3380403) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /label="yxiK gene" CDS complement(3380419..3380715) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391794.1" /db_xref="EnsemblGenomes-Gn:BSU39150" /db_xref="EnsemblGenomes-Tr:CAB15951" /db_xref="InterPro:IPR025551" /db_xref="SubtiList:BG11139" /db_xref="UniProtKB/Swiss-Prot:P42320" /translation="MLQKLRKRQRELEEKQYPDELYGFEAEIYEFFMLVAGSLDYVLA NKRIPRHQRRSLEKSFFELYPDILPDMIKNDKDLYHHILLYEQVRQEICVALSN*" /label="yxiJ CDS" gene complement(3380419..3380715) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /label="yxiJ gene" CDS complement(3380743..3381231) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391795.1" /db_xref="EnsemblGenomes-Gn:BSU39160" /db_xref="EnsemblGenomes-Tr:CAB15952" /db_xref="InterPro:IPR020323" /db_xref="SubtiList:BG11138" /db_xref="UniProtKB/Swiss-Prot:P42301" /translation="MMNWRALSQTKQDRIWSEVNKIIKWKPGSRCHHIIPPDPYRVFD ISSAMSSKAGHNDVSGVLSDLETSILKAFQLGTGKNDVMYALDWQHDGYTFSPHQAMP KDEFGEWPVPVFPNGDYYFFFHQDFSWGLLGDPWKCAITVFGEELLEAIDNDPPILFR NK*" /label="yxiI CDS" gene complement(3380743..3381231) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /label="yxiI gene" CDS complement(3381249..3381701) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391796.1" /db_xref="EnsemblGenomes-Gn:BSU39170" /db_xref="EnsemblGenomes-Tr:CAB15953" /db_xref="SubtiList:BG14170" /db_xref="UniProtKB/Swiss-Prot:O32285" /translation="MWCFTLDGQQKEIHIDRKLEEMDAPAVDDCYGLAEKNGLIYMLY YGDAVIAAFDETVVRRVWILSDKEPDSEAFDQLAISEEGFLVGTFNCYSADLKSSLYL ISADVSQEMEEITCCDSNGEGLDVQQLKLTSYAVYAVASSGVYKQDIQ*" /label="yxzG CDS" gene complement(3381249..3381701) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /label="yxzG gene" S_feature complement(3381702..3381770) /Source="Nicolas_S_feature" /locus_tag="new_4020908_4020976_c" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, T2.0H, T-3.40H, T5.0H, T-2.40H, T-4.40H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19384199999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1509" CDS complement(3381771..3382100) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391797.1" /db_xref="EnsemblGenomes-Gn:BSU39180" /db_xref="EnsemblGenomes-Tr:CAB15954" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11137" /db_xref="UniProtKB/Swiss-Prot:P42300" /translation="MKKLKLNKIINENTQDCFFHADPQGRVYIGKGLKGGITITIYDP SGDVRDFRVKEQISYSDILLFQQCADGYVFVYYESYEPKVKVFSEEGRVKSVFHLPSG VSCCLLD*" /label="yxiH CDS" gene complement(3381771..3382100) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /label="yxiH gene" S_feature complement(3382101..3382222) /Source="Nicolas_S_feature" /locus_tag="new_4021307_4021428_c" /HighExp="T3.30H, T4.0H, T3.0H, T2.30H, T-4.40H, T-3.40H, LBGexp, T-2.40H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1510" CDS complement(3382223..3382639) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391798.1" /db_xref="EnsemblGenomes-Gn:BSU39190" /db_xref="EnsemblGenomes-Tr:CAB15955" /db_xref="SubtiList:BG11136" /db_xref="UniProtKB/Swiss-Prot:P42299" /translation="MTMYQTINEWVDYIDKGCSVLHLDFNVFKKELSLDIKVFEDEGE YTHKISFQNVASAYYSADVGDMRLEKIDPEEYNWQVFEMSYHPEGIGNLSNSIIPEYQ SNANFLIDMNRMLIAIEAETVRFDDQSFYAYQLNTK*" /label="yxiG CDS" gene complement(3382223..3382639) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /label="yxiG gene" CDS complement(3382690..3383058) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391799.1" /db_xref="EnsemblGenomes-Gn:BSU39200" /db_xref="EnsemblGenomes-Tr:CAB15956" /db_xref="SubtiList:BG14167" /db_xref="UniProtKB/Swiss-Prot:O32286" /translation="MVDWKPFGTYLLRKKLQYLNISTVLCILIKNHLVLEYVVIKLSE TNLIECINKIKSVLNGQTTREEVSDWAGTYVYADDPEVEDDRVWDMLILLSGIDLKDS SETYLHSTDDLNDWIKQYTE*" /label="yxzC CDS" gene complement(3382690..3383058) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /label="yxzC gene" CDS complement(3383052..3383522) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391800.1" /db_xref="EnsemblGenomes-Gn:BSU39210" /db_xref="EnsemblGenomes-Tr:CAB15957" /db_xref="SubtiList:BG11135" /db_xref="UniProtKB/Swiss-Prot:P42298" /translation="MQKRLIEKLAENKRRLLMSEIKEKLVPCAERGFTYRFADLAQSR QLLELVLSNSIPANTREVDALEKTEAKQLIWKISQSYVAYDDRDVLLFHQYSSEIGAL VCSFGKCLEHLDCLLECIEFDEGILNHSFILVEPKCQFGLCILHTEYGCELVYW*" /label="yxiF CDS" gene complement(3383052..3383522) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /label="yxiF gene" S_feature complement(3383523..3383847) /Source="Nicolas_S_feature" /locus_tag="new_4022729_4023053_c" /HighExp="T3.30H, T-2.40H, T2.30H, T3.0H, T4.0H, SMMPr, MG 120, C90, T2.0H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1511" CDS complement(3383848..3384276) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /experiment="publication(s) with functional evidences, PMID:1529529, 16306698, 19763274, 23572593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1529529, 16306698, 19763274, 23572593; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin of WapA tRNase" /protein_id="NP_391801.1" /db_xref="EnsemblGenomes-Gn:BSU39220" /db_xref="EnsemblGenomes-Tr:CAB15958" /db_xref="SubtiList:BG10798" /db_xref="UniProtKB/Swiss-Prot:Q07836" /translation="MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDF SAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDY KESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP*" /label="wapI CDS" gene complement(3383848..3384276) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /label="wapI gene" CDS complement(3384338..3391342) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor" /protein_id="NP_391802.2" /db_xref="EnsemblGenomes-Gn:BSU39230" /db_xref="EnsemblGenomes-Tr:CAB15959" /db_xref="GOA:Q07833" /db_xref="InterPro:IPR006530" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR022385" /db_xref="InterPro:IPR031325" /db_xref="SubtiList:BG10797" /db_xref="UniProtKB/Swiss-Prot:Q07833" /translation="MKKRKRRNFKRFIAAFLVLALMISLVPADVLAKSTEEENGNRIA ADDPEETLQKEQTEEAVPFDPKDINKEGEITSERTENTKLYYEGDGVYKQEVYLDPIH TKETPDADWEDISPELKESTSKQVETENAILNSDFQKQMKNGLYATFEHNDHKVTYSL AEAKGPNKTSLTPKDTSADYKTDSNEIVYPDVFPNIDLQTFTFNENIKEDLVLHQYNG YNTFTFQLKTDLQAKEQEDGSIDFSDEKGKVVFSVPKPFMTDSKLDELSGEVERSDKV SYKLEKNEEGYLLHLTADENWLKDPERVYPVSIDPSTSLSVSSDTFVMSAYPTTNYSA SSQKWDANLKAYVLKTGYYDKTTGTNYAFMKFNNLKPIQNMTVTKATLKTYVAHSYYG TKATGLWLDTVNSNYDNAKVTWNTKPASKNIGKADVHKGQWASYDVTAAVKSWNSGGA NYGFKLHTNGNGKEYWKKLISSANSANKPYIEVTYTIPKGNTPTIKAYHNGDSTGYFD ISWKKVEGAKGYKVWIYNGKEYQAISAGNVTSWSTKGKKIWPTSAEIASKRYKLHLDG KDGAELALDPSPVYKNSGGSYATSKNYWIGVSAIFDQGEGAMSAPAKPVIPNVGKAQA PSAKGYNNGNATGYFDLSWKAVSGATGYKVQVFNGKGFETLDLGNQTSWTTKGKKIWP TSAEIKAGKYALHLKDGSGAELPINPGPTYKNAGGDGAKRNYSFKIIAYNKDGEAIAS PAATPALPDIARPKNVTGYLYTNTKSSQTGYVNLIWEKVQNAKGYKVNIYNGKEYQSF DVGDADHWTTQNKNIWPTSEEIKAGSYKLHTDGKGGELALDPSPVYNNANGNYKGKKN YSFTLVAYDANGETIPTAPFNPTFHEGAEFLGTEEYWSIIDIPSGQLNGATGNVIVNE EDLSIDGRGPGLGLSRTYNSLDSSDHLFGQGWYADAETSVISTDGGAMYIDEDATTHR FTKKADGTYQPPTGVYLELTETADQFILKTKDQTNAYFNKKGGKLQKVVDGHNNATVY TYNDKNQLTAITDASGRKLTFTYDENGHVTSITGPKNKKVTYSYENDLLKKVTDTDGT VTSYDYDSEGRLVKQYSANSTEAKPVFTEYQYSGHRLEKAINAKKETYVYSYDADKKT LLMTQPNGRKVQYGYNEAGNPIQVIDDAEGLKITTNTKYEGNNVVEDVDPNDVGTGKA TESYQYDKDGNVTSVKDAYGTETYEYNKNNDVTKMKDTEGNVTDIAYDGLDAVSETDQ SGKSSSAAVYDKYGNQIQSSKDLSASTNILKDGSFEAQKSGWNLTASKDSGKISVIAD KSGVLSGSKALEVLSQSTSAGTDHGYSSATQTVELEPNTTYTLSGKIKTDLAKSRAYF NIDLRDKDQKRIQWIHNEYSALAGKNDWTKRQITFTTPANAGKAVVYMEVDHKDKDGK GKAWFDEVQLEKGEVSSSYNPVQNSSFTSATENWNVSGASVDSEEGFNDDVSLKAART SASQAGSVTKQTVVLGQSANDKPVYLTLTGMSKASSVKFTDEKDYSLQANVTYADGST GIYNAKFPSGTQEWNRAAVVIPKTKPINKVDISILFQKSATGTVWFDDIRLIEGSLLT KSTYDSNGNYVTKEEDELGYATSTDYDETGKKTSETDAKGEKTTYTYDQADQLTNMTL SNGTSILHSYDKEGNEVSKTIRAGADQTYKFEYDVMGKLVKTTDPLGNVLASEYDANS NLTKTISPNGNEVSLSYDGTDRVKSKSYNGTEKYIFTYDKNGNETSVVNKEQNTTKKR TFDNKNRLTELTDRGGSQTWTYPSDSDKLKTFSWIHGDQKGTNQFTYNKLDQMIEMKD STSSYSFDYDENGNVQTFITGNGGGTSFSYDERNLVSSLHIGDKNGGDILTESYEYDA NGNRTTINSSASGKVQYEYGKLNQLVKETHEDGTVIEYTYDGFGNRKTVTTIKDGSSK TVNASFNIMNQLTKVNDESISYDKNGNRTSDGKFTYTWDAEDNLTAVTKKGEDKPFAT YKYDEKGNRIQKTVNGKVTNYFYDGDSLNVLYETDADNNVTKSYTYGDSGQLLSYTEN GKKYFYHYNAHGDIIAISDSTGKTVAKYQYDAWGNPTKTEASDEVKDNRYRYAGYQYD EETGLYYLMARYYEPRNGVFLSLDPDPGSDGDSLDQNGYAYGNNNPVMNVDPDGHWVW LVVNAGFAAYDGYKAYKSGKGWKGAAWAAASNFGPGKIFKGASRAYKFTKKAVKITGH TRHGLNQSIGRNGGRGVNLRAKLNAVRSPKKVIKQPNGATKYVGKKATVVLNKRGKVI TAYGSSRAKGSKHVFHTHGKGNKSKRRR*" /label="wapA CDS" gene complement(3384338..3391342) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /label="wapA gene" misc_feature 3391349..3391363 /Source="Nicolas_upshift_promotors" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3391363 /Source="Nicolas_upshifts" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3391373..3391392) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3391388) /Source="Nicolas_upshifts" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3391407..3391414) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3391504..3392439) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391803.1" /db_xref="EnsemblGenomes-Gn:BSU39240" /db_xref="EnsemblGenomes-Tr:CAB15960" /db_xref="GOA:Q07835" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10796" /db_xref="UniProtKB/Swiss-Prot:Q07835" /translation="MQQDPSISSKQKSTAVIKMVISMVIFGSIGFFSEHTNLPSFELV FVRCLCATLFLGFCWLASGQYKTEKWSKRDVLQTLACGFFLVFNWVFLFKSFEETSVT IAISVYHLAPVLVLLLGSFFYREKLNVISVSSIIICFLGTALISGINGSTSLTQLMGS GIIWAVLAALFYAFTTLLGKGIHNLSPYTTTFLQTGLGVIILIPFIHFGAFADLSQGN WIMVVSTGIIHTGIVYLLFFDSLRFLSTKFISIIVFLDPAVAIVLDTVFTGFRPDLYQ TLGIVMIFAGMALTLVRRQGKANVTAEGTDIEQIQ*" /label="yxxF CDS" gene complement(3391504..3392439) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /label="yxxF gene" downshifts complement(3391725) /Source="Nicolas_upshifts" /id="D2038" /incds=1 /nref=1 /ntot=153 /MaxReadThrough="1.33481" /MaxDrop="2.42407" /score="29.0290332" /energy="-5.9" /TU="NA" /idTUdmin="U3098" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(3392440..3392560) /Source="Nicolas_S_feature" /locus_tag="new_4031646_4031766_c" /HighExp="T3.0H, T1.0H, T3.30H, LBGstat, T1.30H, T0.30H, T4.0H, M9-stat, T2.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="Sig-" /TUlongPSig="0.196" /label="S1512" CDS complement(3392591..3393037) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10913081, 12644671, 17210127" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 12644671, 17210127; Product type f: factor" /codon_start=1 /transl_table=11 /product="phosphate starvation protein (universal stress protein A family)" /protein_id="NP_391804.1" /db_xref="EnsemblGenomes-Gn:BSU39250" /db_xref="EnsemblGenomes-Tr:CAB15961" /db_xref="GOA:P42297" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11134" /db_xref="UniProtKB/Swiss-Prot:P42297" /translation="MFNKMLVAIDGSDMSAKALDAAVHLAKEQQAELSILHVGREAVV TTSSLTGIVYVPEHFIDEIRNEVKKEGLKILENAKEKAAEKGVQAETIYANGEPAHEI LNHAKEKGVSLIVVGSRGISGLKEMMLGSVSHKVSQLSTCPVLIVR*" /label="yxiE CDS" gene complement(3392591..3393037) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /label="yxiE gene" downshifts complement(3392605) /Source="Nicolas_upshifts" /id="D2039" /incds=0 /nref=22 /ntot=144 /MaxReadThrough="4.33955" /MaxDrop="6.75522" /score="45.6082379" /energy="-8.4" /TU="U3098" /idTUdmin="U3099" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3393074..3393093) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3393081) /Source="Nicolas_upshifts" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3393107..3393114) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3393140..3394549) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_391805.2" /db_xref="EnsemblGenomes-Gn:BSU39260" /db_xref="EnsemblGenomes-Tr:CAB15962" /db_xref="GOA:P40740" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG10935" /db_xref="UniProtKB/Swiss-Prot:P40740" /translation="MSSNEKRFPEGFLWGGAVAANQVEGAYNEGGKGLSTADVSPNGI MSPFDESMTSLNLYHNGIDFYHRYKEDIALFAEMGFKAFRTSIAWTRIFPNGDEEEPN EEGLRFYDDLFDELLKHHIEPVVTISHYEMPLGLVKNYGGWKNRKVIEFYERYAKTVF KRYQHKVKYWMTFNEINVVLHAPFTGGGLVFEEGENKLNAMYQAAHHQFVASALAVKA GHDIIPDSKIGCMIAATTTYPMTSKPEDVFAAMENERKTLFFSDVQARGAYPGYMKRY LAENNIEIEMAEGDEELLKEHTVDYIGFSYYMSMAASTDPEELAKSGGNLLGGVKNPY LKSSEWGWQIDPKGLRITLNTLYDRYQKPLFIVENGLGAVDKVEEDGTIQDDYRINYL RDHLIEAREAIADGVELIGYTSWGPIDLVSASTAEMKKRYGFIYVDRDNEGNGTFNRI KKKSFNWYQQVIATNGESL*" /label="bglH CDS" gene complement(3393140..3394549) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /label="bglH gene" CDS complement(3394572..3396401) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /EC_number="2.7.1.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17074746, 8626332" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17074746, 8626332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) beta-glucoside-specific enzyme IIBCA component" /protein_id="NP_391806.2" /db_xref="EnsemblGenomes-Gn:BSU39270" /db_xref="EnsemblGenomes-Tr:CAB15963" /db_xref="GOA:P40739" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011297" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10934" /db_xref="UniProtKB/Swiss-Prot:P40739" /translation="MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQ LEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVF DVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLL AMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILL SIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNY LFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAG ASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAF YGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDG SQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGS VTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDL EQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS*" /label="bglP CDS" gene complement(3394572..3396401) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /label="bglP gene" promotor_no_box complement(3396393..3396493) /Source="Nicolas_upshift_promotors" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="promotor_no_box" upshifts complement(3396433) /Source="Nicolas_upshifts" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="upshifts" S_feature complement(3396435..3396627) /Source="Nicolas_S_feature" /locus_tag="new_4035641_4035833_c" /HighExp="Diami, T0.30H, B60, T0.0H, G150, M9-stat, T1.0H, T1.30H, Gly, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29980099999999998" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.998, 0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1513" promotor_-10 complement(3396608..3396627) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3396627) /Source="Nicolas_upshifts" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3396629..3396762) /Source="Nicolas_S_feature" /locus_tag="new_4035835_4035968_c" /HighExp="S2, HiTm, Sw, S8, M9-stat, Lbstat, S0, T2.0H, Mal, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1514" promotor_-35 complement(3396640..3396647) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3396784..3397092) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391807.1" /db_xref="EnsemblGenomes-Gn:BSU39280" /db_xref="EnsemblGenomes-Tr:CAB15964" /db_xref="SubtiList:BG11071" /db_xref="UniProtKB/Swiss-Prot:P40738" /translation="MLLINKQKDPVFQFLAGTFHQDIETPDDAIQELLIEESKEYLED AIVFLTDFIESEHSDNKKNDYIQSCADGVYLPAFNLEPIDWLKNVIVQIKKSLKKFKR *" /label="yxxE CDS" gene complement(3396784..3397092) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /label="yxxE gene" downshifts complement(3396807) /Source="Nicolas_upshifts" /id="D2040" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.99098" /MaxDrop="5.76651" /score="24.0715465" /energy="-21.3" /TU="U3101,U3102" /idTUdmin="U3101" /TUdmin="-3718" /isTUend="FALSE" /label="downshifts" CDS complement(3397138..3397581) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin factor of the RttD-RttE toxin-antitoxin system" /protein_id="NP_391808.1" /db_xref="EnsemblGenomes-Gn:BSU39290" /db_xref="EnsemblGenomes-Tr:CAB15965" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG11070" /db_xref="UniProtKB/Swiss-Prot:P40737" /translation="MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEV GYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPDIEIYDEFENDKLIFFEGSESAL MSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE*" /label="rtbE CDS" gene complement(3397138..3397581) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /label="rtbE gene" CDS complement(3397578..3399287) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease toxin of the RtbD-RtbE toxin-antitoxin system" /protein_id="NP_391809.2" /db_xref="EnsemblGenomes-Gn:BSU39300" /db_xref="EnsemblGenomes-Tr:CAB15966" /db_xref="GOA:P42296" /db_xref="InterPro:IPR003615" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG11133" /db_xref="UniProtKB/Swiss-Prot:P42296" /translation="MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDAL KGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLS HDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENI NQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVY NTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKI LETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKL INNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQ IDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEK TGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGG KKK*" /label="rtbD CDS" gene complement(3397578..3399287) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /label="rtbD gene" misc_feature complement(3398449..3398468) /Source="Nicolas_upshift_promotors" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3398457) /Source="Nicolas_upshifts" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="upshifts" CDS complement(3399307..3399576) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391810.1" /db_xref="EnsemblGenomes-Gn:BSU39310" /db_xref="EnsemblGenomes-Tr:CAB15967" /db_xref="InterPro:IPR020315" /db_xref="SubtiList:BG11132" /db_xref="UniProtKB/Swiss-Prot:P42295" /translation="MAQEIKMVYDTVKQGLSQLKNSAELKSSLPGHLSGRNHLNVVKS IEQLNKDIKELTEAYASVLAKHIAQTESAVNAMKETDENISSSMK*" /label="yxiC CDS" gene complement(3399307..3399576) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /label="yxiC gene" CDS complement(3399588..3399953) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391811.1" /db_xref="EnsemblGenomes-Gn:BSU39320" /db_xref="EnsemblGenomes-Tr:CAB15968" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG11131" /db_xref="UniProtKB/Swiss-Prot:P42294" /translation="MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHL IHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYS IRRQITRIEHEIEKEKHKK*" /label="yxiB CDS" gene complement(3399588..3399953) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /label="yxiB gene" S_feature complement(3399954..3400019) /Source="Nicolas_S_feature" /locus_tag="new_4039160_4039225_c" /HighExp="T-1.40H, T-3.40H, T2.30H, T-2.40H, T-0.40H, T1.0H, T-1.10H, T-5.40H, T3.30H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1515" promotor_-10 complement(3400006..3400025) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3400019) /Source="Nicolas_upshifts" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3400040..3400043) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3400260..3401669) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 18408032, 18607095, 20883454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 18408032, 18607095, 20883454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan endo-1,5-alpha-L-arabinosidase ([Ca(2+)-dependent]" /protein_id="NP_391812.2" /db_xref="EnsemblGenomes-Gn:BSU39330" /db_xref="EnsemblGenomes-Tr:CAB15969" /db_xref="GOA:P42293" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="InterPro:IPR032291" /db_xref="PDB:2X8F" /db_xref="PDB:2X8S" /db_xref="PDB:2X8T" /db_xref="PDB:4COT" /db_xref="SubtiList:BG11130" /db_xref="UniProtKB/Swiss-Prot:P42293" /translation="MFNRLFRVCFLAALIMAFTLPNSVYAQKPIFKEVSVHDPSIIET NGTFYVFGSHLASAKSNDLMQWQQLTTSVSNDNPLIPNVYEELKETFEWAQSDTLWAA DVTQLADGKYYMYYNACRGDSPRSAMGVAVADNIEGPYKNKGIFLKSGMEGTSSDGTP YDATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLPGQGYGKKLLGG NHSRIEGPYVLYNPDTQYYYLYLSYGGLDATGGYNIRVARSKKPDGPYYDAEGNPMLD VRGKGGTFFDDRSIEPYGVKLMGSYTFETENEKGTGYVSPGHNSAYYDEKTGRSYLIF HTRFPGRGEEHEVRVHQLFMNKDGWPVAAPYRYAGETLKEVKQKDITGTYKLIQHGKD ISADIKQTINIQLNKNHTISGEMTGTWRKTGKNTADITLAGKKYNGVFLRQWDSVREK NVMTFSVLNTSGEAVWGSK*" /label="abnB CDS" gene complement(3400260..3401669) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /label="abnB gene" downshifts complement(3400283) /Source="Nicolas_upshifts" /id="D2041" /incds=0 /nref=2 /ntot=38 /MaxReadThrough="0.825980000000001" /MaxDrop="3.49689" /score="16.962389" /energy="-7.9" /TU="NA" /idTUdmin="U3101" /TUdmin="-7194" /isTUend="FALSE" /label="downshifts" S_feature complement(3401670..3401779) /Source="Nicolas_S_feature" /locus_tag="new_4040876_4040985_c" /HighExp="S2, T2.30H, BC, T2.0H, M9-stat, T3.0H, T3.30H, T4.0H, S1, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1516" CDS complement(3401803..3401967) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097797.1" /db_xref="EnsemblGenomes-Gn:BSU39339" /db_xref="EnsemblGenomes-Tr:CAX52712" /db_xref="UniProtKB/Swiss-Prot:C0H3T6" /translation="MAVSQLMQNLTKQLLHVRERKTDVMQEGETAKELNYEGEDMQAT SSAQNRQTSV*" /label="yxzL CDS" gene complement(3401803..3401967) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /label="yxzL gene" promotor_-10 complement(3401852..3401870) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3401867) /Source="Nicolas_upshifts" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3401881..3401889) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3402159..3402178) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3402175) /Source="Nicolas_upshifts" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3402191..3402198) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3402207..3402214 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3402229..3402248 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3402232 /Source="Nicolas_upshifts" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="upshifts" CDS 3402286..3402732 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391813.2" /db_xref="EnsemblGenomes-Gn:BSU39340" /db_xref="EnsemblGenomes-Tr:CAB15970" /db_xref="GOA:P10943" /db_xref="InterPro:IPR015111" /db_xref="InterPro:IPR023552" /db_xref="InterPro:IPR036482" /db_xref="PDB:1VEA" /db_xref="PDB:1WMQ" /db_xref="PDB:1WPS" /db_xref="PDB:1WPT" /db_xref="PDB:1WPU" /db_xref="PDB:1WPV" /db_xref="PDB:1WRN" /db_xref="PDB:1WRO" /db_xref="PDB:1WRQ" /db_xref="PDB:3BOY" /db_xref="PDB:4H4L" /db_xref="SubtiList:BG10666" /db_xref="UniProtKB/Swiss-Prot:P10943" /translation="MTLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGS MDAHKVVAAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVGL RFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI*" /label="hutP CDS" gene 3402286..3402732 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /label="hutP gene" downshifts 3402737 /Source="Nicolas_upshifts" /id="D2042" /incds=0 /nref=157 /ntot=226 /MaxReadThrough="6.10706" /MaxDrop="5.43744" /score="3.19376411" /energy="-17.8" /TU="U3105" /idTUdmin="U3105" /TUdmin="-7018" /isTUend="FALSE" /label="downshifts" CDS 3402845..3404371 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /EC_number="4.3.1.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9535092, 10220322, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine ammonia-lyase (histidase)" /protein_id="NP_391814.1" /db_xref="EnsemblGenomes-Gn:BSU39350" /db_xref="EnsemblGenomes-Tr:CAB15971" /db_xref="GOA:P10944" /db_xref="InterPro:IPR001106" /db_xref="InterPro:IPR005921" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR022313" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10667" /db_xref="UniProtKB/Swiss-Prot:P10944" /translation="MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERI VRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLR ANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTE RIASLTIEGLQGIIDAFDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDA YSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFA MDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSEN KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRG IEHAASYTKQLFQEMRKVVPSIQQDRVFSYDIERLTDWLKKESLIPDHQNKELRGMNI *" /label="hutH CDS" gene 3402845..3404371 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /label="hutH gene" CDS 3404368..3406026 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /EC_number="4.2.1.49" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15313616, 17395359, 22933560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urocanase" /protein_id="NP_391815.1" /db_xref="EnsemblGenomes-Gn:BSU39360" /db_xref="EnsemblGenomes-Tr:CAB15972" /db_xref="GOA:P25503" /db_xref="InterPro:IPR023636" /db_xref="InterPro:IPR023637" /db_xref="InterPro:IPR035085" /db_xref="InterPro:IPR035400" /db_xref="InterPro:IPR035401" /db_xref="InterPro:IPR036190" /db_xref="PDB:2FKN" /db_xref="SubtiList:BG10668" /db_xref="UniProtKB/Swiss-Prot:P25503" /translation="MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPED LIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANS VLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGS LKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEA LAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYS LDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLEN AFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDM AQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPN RETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSE LADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK*" /label="hutU CDS" gene 3404368..3406026 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /label="hutU gene" CDS 3406039..3407304 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /EC_number="3.5.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16990261, 17395359, 18296777" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16990261, 17395359, 18296777; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazolone-5-propionate hydrolase" /protein_id="NP_391816.1" /db_xref="EnsemblGenomes-Gn:BSU39370" /db_xref="EnsemblGenomes-Tr:CAB15973" /db_xref="GOA:P42084" /db_xref="InterPro:IPR005920" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2BB0" /db_xref="PDB:2G3F" /db_xref="SubtiList:BG11100" /db_xref="UniProtKB/Swiss-Prot:P42084" /translation="MPKQIDTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHE QKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISY LDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETEL KQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFA DIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSADHLVGT SDEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAMIDEGVCVSLATDFNPGSSPTEN IQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMY IPYHYGVNHVHQVMKNGTIVVNREGAILG*" /label="hutI CDS" gene 3406039..3407304 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /label="hutI gene" CDS 3407297..3408256 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /EC_number="3.5.3.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931887, 15355972, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formiminoglutamate hydrolase" /protein_id="NP_391817.1" /db_xref="EnsemblGenomes-Gn:BSU39380" /db_xref="EnsemblGenomes-Tr:CAB15974" /db_xref="GOA:P42068" /db_xref="InterPro:IPR005923" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="PDB:3M1R" /db_xref="SubtiList:BG11099" /db_xref="UniProtKB/Swiss-Prot:P42068" /translation="MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPL SKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHH HIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTED GGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKG LIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQ QPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK*" /label="hutG CDS" gene 3407297..3408256 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /label="hutG gene" S_feature 3408257..3408331 /Source="Nicolas_S_feature" /locus_tag="new_4047463_4047537" /HighExp="Sw, BC, T3.30H, T4.0H, T5.0H, T3.0H, T2.30H, S8, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1517" CDS 3408332..3409759 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="histidine degradation metabolites permease" /protein_id="NP_391818.2" /db_xref="EnsemblGenomes-Gn:BSU39390" /db_xref="EnsemblGenomes-Tr:CAB15975" /db_xref="GOA:P42087" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11101" /db_xref="UniProtKB/Swiss-Prot:P42087" /translation="MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQA GPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWI NWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFA FSGTELIGVTAGESANPQKDIPRSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESP FVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLANENMISSRFKKVTS KGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKR FLKKGGDVKDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYL IYHFKRNVTKAKKISQEEYPADHIL*" /label="hutM CDS" gene 3408332..3409759 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /label="hutM gene" downshifts 3409755 /Source="Nicolas_upshifts" /id="D2043" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="0.7432" /MaxDrop="6.18816" /score="8.21347356" /energy="-11.7" /TU="NA" /idTUdmin="U3105" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3409803..3411104) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /EC_number="2.4.2.2" /EC_number="2.4.2.3" /EC_number="2.4.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 15530033, 16469506, 21707079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 15530033, 16469506, 21707079; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside phosphorylase" /protein_id="NP_391819.2" /db_xref="EnsemblGenomes-Gn:BSU39400" /db_xref="EnsemblGenomes-Tr:CAB15976" /db_xref="GOA:P39142" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR013102" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR017872" /db_xref="InterPro:IPR018090" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="InterPro:IPR036566" /db_xref="PDB:5EP8" /db_xref="SubtiList:BG10985" /db_xref="UniProtKB/Swiss-Prot:P39142" /translation="MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMA IFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAL DVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELA KAMVRIGNNVGRQTMAVISDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLG SQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAY QIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGE PLVTLYANRENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE*" /label="pdp CDS" gene complement(3409803..3411104) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /label="pdp gene" downshifts complement(3409820) /Source="Nicolas_upshifts" /id="D2044" /incds=0 /nref=122 /ntot=224 /MaxReadThrough="1.27022" /MaxDrop="5.60021" /score="14.0361257" /energy="-13.1" /TU="NA" /idTUdmin="U3107" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3411134..3412315) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8550462, 11065368, 12591866, 15849754, 16850406, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 11065368, 12591866, 15849754, 16850406, 25890046; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside Na+(H+) cotransporter" /protein_id="NP_391820.2" /db_xref="EnsemblGenomes-Gn:BSU39410" /db_xref="EnsemblGenomes-Tr:CAB15977" /db_xref="GOA:P39141" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG10984" /db_xref="UniProtKB/Swiss-Prot:P39141" /translation="MKYLIGIIGLIVFLGLAWIASSGKKRIKIRPIVVMLILQFILGY ILLNTGIGNFLVGGFAKGFGYLLEYAAEGINFVFGGLVNADQTTFFMNVLLPIVFISA LIGILQKWKVLPFIIRYIGLALSKVNGMGRLESYNAVASAILGQSEVFISLKKELGLL NQQRLYTLCASAMSTVSMSIVGAYMTMLKPEYVVTALVLNLFGGFIIASIINPYEVAK EEDMLRVEEEEKQSFFEVLGEYILDGFKVAVVVAAMLIGFVAIIALINGIFNAVFGIS FQGILGYVFAPFAFLVGIPWNEAVNAGSIMATKMVSNEFVAMTSLTQNGFHFSGRTTA IVSVFLVSFANFSSIGIIAGAVKGLNEKQGNVVARFGLKLLYGATLVSFLSAAIVGLI Y*" /label="nupC CDS" gene complement(3411134..3412315) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /label="nupC gene" S_feature complement(3412316..3412395) /Source="Nicolas_S_feature" /locus_tag="new_4051522_4051601_c" /HighExp="G150, G135, Oxctl, G180, Mt0, M40t45, Lbtran, M0t90, M40t90, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1518" CDS complement(3412396..3413067) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /EC_number="4.1.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 27033207" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 27033207; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyribose-phosphate aldolase" /protein_id="NP_391821.2" /db_xref="EnsemblGenomes-Gn:BSU39420" /db_xref="EnsemblGenomes-Tr:CAB15978" /db_xref="GOA:P39121" /db_xref="InterPro:IPR002915" /db_xref="InterPro:IPR011343" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR028581" /db_xref="SubtiList:BG10983" /db_xref="UniProtKB/Swiss-Prot:P39121" /translation="MSLANIIDHTALKPHTQKADILKLIEEAKTYKFASVCVNPTWVE LAAKELKGTGVDVCTVIGFPLGANTTETKAFETKDAISKGATEVDMVINIAALKDKED DVVEADIRGVVEAVAGKALVKVIIETCLLTDEEKERACRLAVSAGADFVKTSTGFSTG GATKEDIALMRKTVGPDIGVKASGGVRTKEDVDTMVEAGASRIGASAGVSIVKGENAS GGDNY*" /label="deoC CDS" gene complement(3412396..3413067) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /label="deoC gene" promotor_-35 3413016..3413019 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3413034 /Source="Nicolas_upshifts" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3413035..3413054 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3413095..3413114) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3413110) /Source="Nicolas_upshifts" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3413128..3413135) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3413173..3414114) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 10714997, 24863636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 10714997, 24863636; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of pyrmidine deoxyribonucleosides degradation (DeoR-dR5P)" /protein_id="NP_391822.1" /db_xref="EnsemblGenomes-Gn:BSU39430" /db_xref="EnsemblGenomes-Tr:CAB15979" /db_xref="GOA:P39140" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR013324" /db_xref="PDB:4OQP" /db_xref="PDB:4OQQ" /db_xref="SubtiList:BG10982" /db_xref="UniProtKB/Swiss-Prot:P39140" /translation="MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYA KEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYM HETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLF AEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALL FRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSIL VAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL*" /label="deoR CDS" gene complement(3413173..3414114) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /label="deoR gene" promotor_-10 complement(3414159..3414178) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3414165) /Source="Nicolas_upshifts" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3414167..3414247) /Source="Nicolas_S_feature" /locus_tag="new_4053373_4053453_c" /HighExp="Etha, Diami, Salt, MG 10, Gly, MG 60, G180, GM 60, G135, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.55204399999999998" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1519" promotor_-35 complement(3414194..3414197) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 3414263..3414264 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_018" promotor_-35 3414360..3414366 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3414382..3414400 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3414392 /Source="Nicolas_upshifts" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="upshifts" CDS 3414454..3415839 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391860.1" /db_xref="EnsemblGenomes-Gn:BSU39810" /db_xref="EnsemblGenomes-Tr:CAB16017" /db_xref="GOA:P46333" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11360" /db_xref="UniProtKB/Swiss-Prot:P46333" /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTL TEGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIA SRVILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFE AWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAE MKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGT SASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLS ASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVS LVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKS TQNQVLNERTL*" /label="csbC CDS" gene 3414454..3415839 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /label="csbC gene" downshifts 3415825 /Source="Nicolas_upshifts" /id="D2056" /incds=0 /nref=69 /ntot=115 /MaxReadThrough="4.59405" /MaxDrop="7.32264" /score="22.9943012" /energy="-16.4" /TU="NA" /idTUdmin="U3131" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 3415870..3416420 /Source="Nicolas_S_feature" /locus_tag="new_4089418_4089968" /HighExp="Etha, C30, C90, Gly, Sw, G135, Fru, HiTm, M/G, Mal" /AntisenseName="htpG" /AntisenseCor="7.4766600377621104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1530" CDS complement(3415881..3417761) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III heat-shock protein (ATP-dependent molecular chaperone HSP90)" /protein_id="NP_391861.1" /db_xref="EnsemblGenomes-Gn:BSU39820" /db_xref="EnsemblGenomes-Tr:CAB16018" /db_xref="GOA:P46208" /db_xref="InterPro:IPR001404" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR019805" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020575" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037196" /db_xref="SubtiList:BG11359" /db_xref="UniProtKB/Swiss-Prot:P46208" /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIY YKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAF KKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEG SENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGA VRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSED LSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVY NDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQT EMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESK YKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAE KVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKV MV*" /label="htpG CDS" gene complement(3415881..3417761) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /label="htpG gene" downshifts complement(3415887) /Source="Nicolas_upshifts" /id="D2057" /incds=0 /nref=169 /ntot=288 /MaxReadThrough="0.81611" /MaxDrop="6.49379" /score="34.0973015" /energy="-16.4" /TU="NA" /idTUdmin="U3132" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" S_feature complement(3417762..3417859) /Source="Nicolas_S_feature" /locus_tag="new_4091310_4091407_c" /HighExp="Lbtran, S1, LBGtran, C90, M40t45, M9-tran, GM 150, dia0, T-2.40H, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="SigA" /TUlongPSig="0.995" /label="S1531" promotor_-10 complement(3417850..3417869) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3417859) /Source="Nicolas_upshifts" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3417884..3417891) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3417929..3418180) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391862.1" /db_xref="EnsemblGenomes-Gn:BSU39830" /db_xref="EnsemblGenomes-Tr:CAB16019" /db_xref="GOA:P46332" /db_xref="SubtiList:BG11358" /db_xref="UniProtKB/Swiss-Prot:P46332" /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFL NASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG*" /label="yxcA CDS" gene complement(3417929..3418180) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /label="yxcA gene" downshifts complement(3417947) /Source="Nicolas_upshifts" /id="D2058" /incds=0 /nref=11 /ntot=62 /MaxReadThrough="3.50049" /MaxDrop="5.56962" /score="-3.89567108" /energy="-6.7" /TU="U3133" /idTUdmin="U3133" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" misc_feature complement(3418202..3418221) /Source="Nicolas_upshift_promotors" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3418211) /Source="Nicolas_upshifts" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="upshifts" promotor_-35 3418244..3418250 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3418264..3418282 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3418265 /Source="Nicolas_upshifts" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="upshifts" CDS 3418297..3419118 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391863.2" /db_xref="EnsemblGenomes-Gn:BSU39840" /db_xref="EnsemblGenomes-Tr:CAB16020" /db_xref="GOA:P46331" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11357" /db_xref="UniProtKB/Swiss-Prot:P46331" /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQME ETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHE YPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG GITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPL GRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK*" /label="yxbG CDS" gene 3418297..3419118 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /label="yxbG gene" downshifts 3419102 /Source="Nicolas_upshifts" /id="D2059" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="2.87575" /MaxDrop="5.67438" /score="22.9485028" /energy="-10.5" /TU="U3134" /idTUdmin="U3134" /TUdmin="-221" /isTUend="FALSE" /label="downshifts" CDS complement(3419147..3420289) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11160890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391864.1" /db_xref="EnsemblGenomes-Gn:BSU39850" /db_xref="EnsemblGenomes-Tr:CAB16021" /db_xref="GOA:P46330" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG11356" /db_xref="UniProtKB/Swiss-Prot:P46330" /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLY YEDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSV MMNRGHFHRFFKDVFQQDVLLAPIHVNLTPIERDIYGHYRALYTYAIILYWLNEDAAA SPEAISQKVWELVSQKRFYWLFGKAVPGEREKEKQIDRRVVRTREALQKAFLDVLAEK QDYAGITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNEFS LKEAEKALAILLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKL YAHYVSAMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL*" /label="yxbF CDS" gene complement(3419147..3420289) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /label="yxbF gene" downshifts complement(3419157) /Source="Nicolas_upshifts" /id="D2060" /incds=0 /nref=10 /ntot=163 /MaxReadThrough="1.63217" /MaxDrop="3.79969" /score="-0.564494299" /energy="-10.5" /TU="NA" /idTUdmin="U3135" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3420290..3420389) /Source="Nicolas_S_feature" /locus_tag="new_4093838_4093937_c" /HighExp="H2O2, Diami, dia15, Paraq, G180, G135, G150, dia5, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1532" promotor_-10 complement(3420377..3420396) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3420388) /Source="Nicolas_upshifts" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3420410..3420417) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3420432..3421769 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /EC_number="1.2.1.3" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391865.2" /db_xref="EnsemblGenomes-Gn:BSU39860" /db_xref="EnsemblGenomes-Tr:CAB16022" /db_xref="GOA:P46329" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11355" /db_xref="UniProtKB/Swiss-Prot:P46329" /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIA HEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANG ILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRD AFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGK SPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGF MEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKN VTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHT TSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE*" /label="aldX CDS" gene 3420432..3421769 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /label="aldX gene" S_feature complement(3421174..3421774) /Source="Nicolas_S_feature" /locus_tag="new_4094722_4095322_c" /HighExp="T1.30H, T2.30H, T2.0H, T1.0H, T-2.40H, T3.0H, T3.30H, T0.0H, T-0.40H, T-3.40H" /AntisenseName="aldX" /AntisenseCor="-0.39894728806999702" /AntisenseRegPval="-11" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1533" CDS complement(3421808..3422287) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391866.2" /db_xref="EnsemblGenomes-Gn:BSU39870" /db_xref="EnsemblGenomes-Tr:CAB16023" /db_xref="GOA:P46328" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11354" /db_xref="UniProtKB/Swiss-Prot:P46328" /translation="MNIIPTCQVPKDLVSAFFQKHWGSPQMVISSGIYNCDELDGYGM LNDDNQIVGLITYIFEEDACEIISLDSVIENKGIGTALLEKAEEACRERNIKQIKLIT TNDNIHALAFYQKRGYRLDRLFVNAVETARKMKPEIPLLADNKIPIRDELLLVKELQ* " /label="yxbD CDS" gene complement(3421808..3422287) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /label="yxbD gene" downshifts complement(3421819) /Source="Nicolas_upshifts" /id="D2061" /incds=0 /nref=1 /ntot=39 /MaxReadThrough="3.82941" /MaxDrop="2.52984" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3422367..3423359) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391867.1" /db_xref="EnsemblGenomes-Gn:BSU39880" /db_xref="EnsemblGenomes-Tr:CAB16024" /db_xref="GOA:P46327" /db_xref="InterPro:IPR003347" /db_xref="PDB:1VRB" /db_xref="SubtiList:BG11353" /db_xref="UniProtKB/Swiss-Prot:P46327" /translation="MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIP GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDF TDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEK TWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYL PRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESS KSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF*" /label="yxbC CDS" gene complement(3422367..3423359) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /label="yxbC gene" downshifts complement(3422391) /Source="Nicolas_upshifts" /id="D2062" /incds=0 /nref=5 /ntot=98 /MaxReadThrough="5.86537" /MaxDrop="5.28716" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-1188" /isTUend="FALSE" /label="downshifts" downshifts 3423349 /Source="Nicolas_upshifts" /id="D2063" /incds=0 /nref=2 /ntot=56 /MaxReadThrough="1.15059" /MaxDrop="3.74519" /score="9.93493822" /energy="-12.4" /TU="NA" /idTUdmin="U3134" /TUdmin=4026 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3423382..3423401) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3423400) /Source="Nicolas_upshifts" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3423416..3423423) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3423422..3423429 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3423443..3423867 /Source="Nicolas_S_feature" /locus_tag="new_4096991_4097415" /HighExp="T2.0H, T5.0H, M9-stat, T3.0H, T1.30H, T1.0H, T3.30H, T2.30H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998942" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1534" upshifts 3423443 /Source="Nicolas_upshifts" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3423444..3423463 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 3423449..3423861 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /product="putative small RNA or mRNA leader sequence" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="srlX RNA" gene 3423449..3423861 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /label="srlX gene" upshifts complement(3423469) /Source="Nicolas_upshifts" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3423479..3423493) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3423501..3423505) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3423833 /Source="Nicolas_upshifts" /id="D2064" /incds=0 /nref=2 /ntot=9 /MaxReadThrough="8.39077" /MaxDrop="5.02548" /score="9.93493822" /energy="-12.4" /TU="U3137" /idTUdmin="U3134" /TUdmin=4510 /isTUend="FALSE" /label="downshifts" CDS 3423868..3424602 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /EC_number="2.1.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941984, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_391868.1" /db_xref="EnsemblGenomes-Gn:BSU39890" /db_xref="EnsemblGenomes-Tr:CAB16025" /db_xref="GOA:P46326" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11352" /db_xref="UniProtKB/Swiss-Prot:P46326" /translation="MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMG TGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQEEAKKSGVSSLISFDLEDVHHLSYAD QYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEIMRKQIKEP EYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQ NDQSTDHEIESVTWMLTIEKEKEGAL*" /label="yxbB CDS" gene 3423868..3424602 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /label="yxbB gene" CDS 3424602..3424871 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17083466" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391869.1" /db_xref="EnsemblGenomes-Gn:BSU39900" /db_xref="EnsemblGenomes-Tr:CAB16026" /db_xref="InterPro:IPR008792" /db_xref="SubtiList:BG11351" /db_xref="UniProtKB/Swiss-Prot:P46325" /translation="MINESTVLSKNPEMPSRKYLKSIIIEPGITLNEMASDIYNHIDG KVSIHDICSKIVNEYDVDYQTCLEDCMELFELLIDHEAIKVKQGA*" /label="yxbA CDS" gene 3424602..3424871 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /label="yxbA gene" CDS 3424875..3425357 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20185509" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391870.1" /db_xref="EnsemblGenomes-Gn:BSU39910" /db_xref="EnsemblGenomes-Tr:CAB16027" /db_xref="SubtiList:BG14166" /db_xref="UniProtKB/Swiss-Prot:O34704" /translation="MEKQKVLALPDDVHELSTHRSKSIVNYIITLLAFAKKQGLTHQD IVSWIHEQYEERGYYDEWRHINSQQPVGSFVELFIKGRRLLYDKIELFETEDKYVVNT HTWYEKEPSEAFFYFEIDPEEFSAYASILAIENAKRLGIKIDIVKETDVETAYIYKHQ *" /label="yxnB CDS" gene 3424875..3425357 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /label="yxnB gene" CDS 3425378..3427621 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /EC_number="6.3.5.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 17083466, 20185509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 17083466, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (glutamine-hydrolyzing)" /protein_id="NP_391871.2" /db_xref="EnsemblGenomes-Gn:BSU39920" /db_xref="EnsemblGenomes-Tr:CAB16028" /db_xref="GOA:P42113" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11116" /db_xref="UniProtKB/Swiss-Prot:P42113" /translation="MCGLAGIINLAAPRSQECTFHILKGMADAISYRGPDDEQYHIDS KVGFAFRRLSILDLVNGQQPFLNEDGSIVVMVNGEIYNYKELKASLHNHMFKTTSDCE VIVHLYEEKGIGFVDDIIGMFSIAIWDKNKNKVFLVRDRFGIKPLFYTELKHELIFAS EIKSLFSHPHCPRQFNWKEALSDIWLSGEAASNHKETTSFFVNIQNLDAGHYLEINLT TNERKTASYWSLQDILLRQGYRENLHPDDLIEGYRELLADSVHRCLQSDVEVGLFLSG GIDSAAVAHFAAEKQDLHTFTVLSQSTFTNEDAKYAHWLAKDLHLPNHQVLYQLGNDE LLQPESYKHLLWICETPFCGPEQLYKFHLHKYAKAIRPNLKVMLTGQGSDEFNGGYST TLSPAENPSWEGFIESVNTMEMNRLHRLQGNIFRVWEEHFGLSPINLSYLKSNDSSQA DPWQSYVLTKYRDLQMYNCWHEDRIAAANHIENRVPFLDHRLVEWVCGIPDGLRKDLL WDKSVLRKSLTNELHTSYTHRPKVPFFYGKDVRYTHKMMFHLLKKNNYQLIEEAFSHS DASSIIQVEHIHAIMTYLEDDPEFTNFEFLLRLVNMGLLSKMTKETPSVQLDITSHLE SITIKDWHSQEGDIASRLNISANKCEGQDILALNPGVTLLRPESDSEHCIYIAEEGFI QFIVSEEDVGAWLHILCDINGKDTLHTILDRHGVSLEEVAKYIQEAIEHNIILIKQKN LPEGAYR*" /label="asnH CDS" gene 3425378..3427621 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /label="asnH gene" CDS 3427618..3428817 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989, 15849754, 16850406, 20185509; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391872.2" /db_xref="EnsemblGenomes-Gn:BSU39930" /db_xref="EnsemblGenomes-Tr:CAB16029" /db_xref="GOA:P42112" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11115" /db_xref="UniProtKB/Swiss-Prot:P42112" /translation="MSIFYSFSALRGLAMGIFSPIWILYLISKDYDFLQIGLMGAVLE IAKLIFEVPSGVFADRYGIKISIASSFFFSILTWAFFPFIDSAAICILAMIIWALSDS LISGSFETWMSRVAGEDRFGKEMMKNTQLLITFLIIGSIASGYLYSLNIYFPFLLVMV IYLLLFIWMSVFIKVPSVSETNHGDQNQHDSIKIIKESLKIIFNKKRVLLIVIAGFFT ATAYDTISRYWQPFLSDLGFSEKSLGYIFALGGFTALVLLTLTIRFEKKIEKNPYLAL TSLDSMGMVMTFLLSRAFRPLGIPCTAFLLAIEDIHHPIVTSYLNKFFPDSYKNTLFS LNSGVGAIGEILSGVIFGIISAAFGLSAMFVVVAVFLLIPIILYTIVPKIKDNDMKVQ IEKSQQV*" /label="yxaM CDS" gene 3427618..3428817 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /label="yxaM gene" promotor_-10 complement(3428573..3428591) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3428595) /Source="Nicolas_upshifts" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3428606..3428612) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3428808 /Source="Nicolas_upshifts" /id="D2065" /incds=0 /nref=71 /ntot=174 /MaxReadThrough="3.22879" /MaxDrop="5.42242" /score="-6.94914943" /energy="-8.5" /TU="U3137" /idTUdmin="U3137" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts complement(3428881) /Source="Nicolas_upshifts" /id="D2066" /incds=0 /nref=156 /ntot=227 /MaxReadThrough="3.53794" /MaxDrop="6.77896" /score="7.32872401" /energy="-16.9" /TU="U3140" /idTUdmin="U3141" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3428881..3430113) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 15743949, 17060472, 18165306, 22720735, 26060272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane associated protein kinase with beta-propeller domain" /protein_id="NP_391873.2" /db_xref="EnsemblGenomes-Gn:BSU39940" /db_xref="EnsemblGenomes-Tr:CAB16030" /db_xref="GOA:P42111" /db_xref="InterPro:IPR002372" /db_xref="InterPro:IPR011047" /db_xref="InterPro:IPR018391" /db_xref="SubtiList:BG11114" /db_xref="UniProtKB/Swiss-Prot:P42111" /translation="MVKSFRMKALIAGAAVAAAVSAGAVSDVPAAKVLQPTAAYAAET VFSQNNGASGFLPGRYDVQAMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGA VIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLGKTYTQSPVLGTNGVIYLASYDKKI YFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKSTWTERWKL KTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGN IYAGNQDGQLYAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGD MNWSFYTDGPVRTAPLIDAKGTVYFGSDDMKVYAADANGNELWSYQTDSNVVSSPQLA EDGTLYIGSYTKLMAFGK*" /label="yxaL CDS" gene complement(3428881..3430113) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /label="yxaL gene" promotor_-10 complement(3430145..3430164) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3430157) /Source="Nicolas_upshifts" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3430178..3430183) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3430214..3430639) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949, 15849754, 16850406, 27902860; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391875.2" /db_xref="EnsemblGenomes-Gn:BSU39950" /db_xref="EnsemblGenomes-Tr:CAB16032" /db_xref="GOA:P42109" /db_xref="InterPro:IPR020204" /db_xref="SubtiList:BG11112" /db_xref="UniProtKB/Swiss-Prot:P42109" /translation="MSKKNSVAIMTTISAFLFCAVIVAASLSPLAGTGAAANQFNSAG MWSAVGMILVLYFIPFLVYMLGVDAMRYVMAVLCGFGLLIHLSSAGFILMFSFFSDHL LSEVIFVLGVSLAAAAVNVIWFVAAFRSGAEKTSVNTLT*" /label="yxaJ CDS" gene complement(3430214..3430639) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /label="yxaJ gene" promotor_-10 complement(3430667..3430686) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3430681) /Source="Nicolas_upshifts" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3430699..3430705) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3430831..3430838 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3430848 /Source="Nicolas_upshifts" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3430853..3430872 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3430896..3431351 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391876.1" /db_xref="EnsemblGenomes-Gn:BSU39960" /db_xref="EnsemblGenomes-Tr:CAB16033" /db_xref="GOA:P42108" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11111" /db_xref="UniProtKB/Swiss-Prot:P42108" /translation="MEKPAGFWIRFLAYFIDGIIVSVPSYIILFIINSVFVAGAVATN PYMTEEEYLVKYMTLAFLPTMLIMIVISVLYYGLLTASKMQGTLGKKILGLKVVNEQG ERVSVGQGIGRYFAYILSGIIFYIGFIMIAFGEKKGLHDIICKTRVVYK*" /label="yxaI CDS" gene 3430896..3431351 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /label="yxaI gene" downshifts 3431289 /Source="Nicolas_upshifts" /id="D2067" /incds=1 /nref=58 /ntot=234 /MaxReadThrough="3.24719" /MaxDrop="5.4441" /score="18.1083522" /energy="-13.4" /TU="U3142" /idTUdmin="U3142" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" S_feature 3431352..3431965 /Source="Nicolas_S_feature" /locus_tag="new_4104900_4105513" /HighExp="LPh, HPh, MG 60, BMM, MG t5, G180, MG 45, G150, MG-0.2, MG 10" /AntisenseName="yxaH" /AntisenseCor="0.37646026982403002" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1535" CDS complement(3431381..3432589) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein involved in response to flavonoids" /protein_id="NP_391877.2" /db_xref="EnsemblGenomes-Gn:BSU39970" /db_xref="EnsemblGenomes-Tr:CAB16034" /db_xref="GOA:P42107" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11110" /db_xref="UniProtKB/Swiss-Prot:P42107" /translation="MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSM LGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVP LYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLF SIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGML TYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLY SVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVC TWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLS WQPIAKKTKV*" /label="yxaH CDS" gene complement(3431381..3432589) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /label="yxaH gene" downshifts complement(3431408) /Source="Nicolas_upshifts" /id="D2068" /incds=0 /nref=14 /ntot=66 /MaxReadThrough="0.30987" /MaxDrop="3.782" /score="34.1593124" /energy="-16.2" /TU="NA" /idTUdmin="U3143" /TUdmin=286 /isTUend="FALSE" /label="downshifts" S_feature complement(3432590..3432696) /Source="Nicolas_S_feature" /locus_tag="new_4106138_4106244_c" /HighExp="T-5.40H, T-4.40H, SMMPr, T-2.40H, T-3.40H, T-1.40H, Sw, T0.0H, Pyr, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1536" CDS complement(3432697..3433710) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /EC_number="1.13.11.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quercetin dioxygenase" /protein_id="NP_391878.2" /db_xref="EnsemblGenomes-Gn:BSU39980" /db_xref="EnsemblGenomes-Tr:CAB16035" /db_xref="GOA:P42106" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:1Y3T" /db_xref="PDB:2H0V" /db_xref="SubtiList:BG11109" /db_xref="UniProtKB/Swiss-Prot:P42106" /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGD LFEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTP HSYRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVAD IVFLDEAKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQF IVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQEIQLNPGDFLHVPANTVHS YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALRFDRILQNIEALDLKV MKP*" /label="qdoI CDS" gene complement(3432697..3433710) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /label="qdoI gene" S_feature complement(3433711..3433784) /Source="Nicolas_S_feature" /locus_tag="new_4107259_4107332_c" /HighExp="T-3.40H, T-5.40H, T-1.40H, T-2.40H, T-4.40H, T-0.40H, T0.0H, Pyr, SMMPr, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1537" promotor_-10 complement(3433769..3433788) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3433784) /Source="Nicolas_upshifts" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3433801..3433808) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3433804..3434379) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17483215, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483215, 21737930; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of qdoI" /protein_id="NP_391879.2" /db_xref="EnsemblGenomes-Gn:BSU39990" /db_xref="EnsemblGenomes-Tr:CAB16036" /db_xref="GOA:P42105" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1SGM" /db_xref="SubtiList:BG11108" /db_xref="UniProtKB/Swiss-Prot:P42105" /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLY HFFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPVEAIQLFIKKTASQFDNTESIK GIPVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMI EGGIMLSLTNKDKTPLLLIAEQIPVLVRKKG*" /label="qdoR CDS" gene complement(3433804..3434379) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /label="qdoR gene" downshifts complement(3433828) /Source="Nicolas_upshifts" /id="D2069" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="1.66581" /MaxDrop="2.62803" /score="-2.51956315" /energy="-8.8" /TU="NA" /idTUdmin="U3144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3434408..3434427) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3434422) /Source="Nicolas_upshifts" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3434442..3434449) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3434450..3434456 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3434471..3434489 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3434478 /Source="Nicolas_upshifts" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="upshifts" CDS 3434510..3435580 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391880.2" /db_xref="EnsemblGenomes-Gn:BSU40000" /db_xref="EnsemblGenomes-Tr:CAB16037" /db_xref="GOA:O32291" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14165" /db_xref="UniProtKB/Swiss-Prot:O32291" /translation="MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIG LVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETA ISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVP GALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDT PYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALF PRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATK RPIVSAAVVAGLVAWAAAKRCR*" /label="yxnA CDS" gene 3434510..3435580 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /label="yxnA gene" downshifts 3435578 /Source="Nicolas_upshifts" /id="D2070" /incds=0 /nref=7 /ntot=44 /MaxReadThrough="2.68466" /MaxDrop="3.96227" /score="-3.48213422" /energy="-11.2" /TU="NA" /idTUdmin="U3145" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3435637..3436068) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391881.1" /db_xref="EnsemblGenomes-Gn:BSU40010" /db_xref="EnsemblGenomes-Tr:CAB16038" /db_xref="GOA:P42103" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11106" /db_xref="UniProtKB/Swiss-Prot:P42103" /translation="MQNQNPVELIEYELTTFIRRAVYLDQSEKRTGNLERSSYLLLRQ LDEFGPARVKELAESFKLDISTLSRQAAALEAKELIYRFSDPSDGRVSLFTITKLGKQ LLKADQQKRLERYEQMLKEWSTQEKEMFGELLQRMNKAFID*" /label="yxaD CDS" gene complement(3435637..3436068) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /label="yxaD gene" promotor_-35 3436098..3436105 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3436119..3436138 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3436128..3436294 /Source="Nicolas_S_feature" /locus_tag="new_4109676_4109842" /HighExp="LBGstat, Cold, Heat, Salt, Etha, H2O2, G180, LBGtran, GM 150, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1538" upshifts 3436128 /Source="Nicolas_upshifts" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3436180..3436199) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3436200) /Source="Nicolas_upshifts" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3436214..3436221) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3436295..3436699 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein involved in export murein hydrolases" /protein_id="YP_003097798.1" /db_xref="EnsemblGenomes-Gn:BSU40021" /db_xref="EnsemblGenomes-Tr:CAX52713" /db_xref="GOA:C0H3T7" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/Swiss-Prot:C0H3T7" /translation="MKVIRIILQVLILYVFFMIGEAIQHLFHLPVSGSIVGLVLLLIC LGLRIVPVSIIEDGAGFLLSFLPLLFIPAMTGVINYPSLISFNGLMLLITVVLSTIVT IIAAGFASQLLEKKAKKREEKEKCSKHVSRSL*" /label="yxzK CDS" gene 3436295..3436699 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /label="yxzK gene" S_feature complement(3436316..3437368) /Source="Nicolas_S_feature" /locus_tag="new_4109864_4110916_c" /HighExp="Etha, C30, H2O2, Salt, Paraq, GM 120, Diami, Oxctl, G180, Sw" /AntisenseName="yxaC" /AntisenseCor="0.145103505386703" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1539" CDS 3436669..3437361 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative murein hydrolase export regulator" /protein_id="NP_391882.3" /db_xref="EnsemblGenomes-Gn:BSU40022" /db_xref="EnsemblGenomes-Tr:CAB16039" /db_xref="GOA:P42102" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG11105" /db_xref="UniProtKB/Swiss-Prot:P42102" /translation="MQQACIAIIIILLTVAAYLAMVKLYKRFPLPFLIPVLTTTILIV AALMMFHVSYEGYMIGGKWINSLLGPAVVALAYPLYKQWHIIVKHCVPILGGVLVGLC MGMISGLIFAEAFGIDHDLLLSILPKSITTPVAIQIAAGLGGVPSMTVVFVMIAGFSG VILGPLFLKWLRIRSSLGQGIALGSASHALGTSKALEYGELAVSMSSVSMTLCAVLGS FFGPLVVWLFHI*" /label="yxaC CDS" gene 3436669..3437361 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /label="yxaC gene" CDS complement(3437401..3438432) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /EC_number="2.-.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9298659, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exopolysaccharide pyruvyl transferase (biofilm formation)" /protein_id="NP_391883.3" /db_xref="EnsemblGenomes-Gn:BSU40030" /db_xref="EnsemblGenomes-Tr:CAB16040" /db_xref="GOA:P42101" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11104" /db_xref="UniProtKB/Swiss-Prot:P42101" /translation="MTVQEIKGKKLVKGIAPNVEPEALLNDKRKVFLFGSPSYTNIGD QAIAYAEEKFIKNHFPYYEYIEIMDYATDEGIELVKEIIREDDIVCFTGGGNLGNLYL DIEEDRRKVFSAFKDYKSISLPQSVYFEDTEEGQKEKKKTQDAYHQNTNLTIAARETQ TLDVVKETFNSNVIFTPDMVLSLDIVPRELERDGVLFILRADKEKVTDEDFISQMKQW AEKTTYTERTDTVLDTVDTIDYADREKHFMEMLDRIGSSKLVITDRLHAMIFSIITKT PCLVFGNSYGKAKHSYRDWLESLNFIEYTDKNDVEELERMIDRLLQAEPNDVDLSKDF QPLIDFFAS*" /label="yxaB CDS" gene complement(3437401..3438432) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /label="yxaB gene" downshifts complement(3437413) /Source="Nicolas_upshifts" /id="D2071" /incds=0 /nref=5 /ntot=94 /MaxReadThrough="6.52386" /MaxDrop="4.6522" /score="17.8326496" /energy="-15.3" /TU="U3149" /idTUdmin="U3150" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-35 3438399..3438402 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3438415 /Source="Nicolas_upshifts" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3438419..3438438 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3438469..3438487) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3438487) /Source="Nicolas_upshifts" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3438502..3438508) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3438525..3439673) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /EC_number="2.7.1.31" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15771780, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-glycerate kinase" /protein_id="NP_391884.2" /db_xref="EnsemblGenomes-Gn:BSU40040" /db_xref="EnsemblGenomes-Tr:CAB16041" /db_xref="GOA:P42100" /db_xref="InterPro:IPR004381" /db_xref="InterPro:IPR018193" /db_xref="InterPro:IPR036129" /db_xref="SubtiList:BG11103" /db_xref="UniProtKB/Swiss-Prot:P42100" /translation="MKIIIAPDSFKESLSALEAAEAIERGFKSVFPGADYRKLPVADG GEGTVQSLVDATNGRIIEQVVTGPLGEPVRAFFGMMGDGRTAVIEMAAASGLHLVPVD KRNPLITTTRGTGELIGAALDAGAERLIIGIGGSATNDGGAGMIQALGGRLLDNSGSE IGPGGGALSQLASIDVSGLDSRLRNVKLEVACDVDNPLTGPKGATAVFGPQKGATADM LDVLDQNVSHFADMAEKALGSTFRDTEGAGAAGGLGWSLLTYLQADLKRGIDIVLEAV DFESIVQDADLVITGEGRIDSQTVHGKTPIGVAKAAKSYDVPVIGIAGSISRDSNAVY QHGIDALFSIVPGAVPLEDAFEHAAEYMERTARDIAASIKLAKTMFLI*" /label="glxK CDS" gene complement(3438525..3439673) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /label="glxK gene" promotor_-10 complement(3439712..3439731) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3439723) /Source="Nicolas_upshifts" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3439742..3439749) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3439795..3439802 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3439816..3439835 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3439823 /Source="Nicolas_upshifts" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3439869..3440600 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7476858, 7642511, 8655507, 9106211, 26151451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7476858, 7642511, 8655507, 9106211, 26151451; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR-gluconate)" /protein_id="NP_391885.1" /db_xref="EnsemblGenomes-Gn:BSU40050" /db_xref="EnsemblGenomes-Tr:CAB16042" /db_xref="GOA:P10585" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10648" /db_xref="UniProtKB/Swiss-Prot:P10585" /translation="MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSE NTIAAEFSVSRSPVREALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFV FERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFD DVQDKVEDLWLSQQMLAKGAEYNND*" /label="gntR CDS" gene 3439869..3440600 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /label="gntR gene" CDS 3440593..3442134 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /EC_number="2.7.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1659648, 2537826, 3020045, 11468405" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1659648, 2537826, 3020045, 11468405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-gluconate kinase" /protein_id="NP_391886.1" /db_xref="EnsemblGenomes-Gn:BSU40060" /db_xref="EnsemblGenomes-Tr:CAB16043" /db_xref="GOA:P12011" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006002" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10649" /db_xref="UniProtKB/Swiss-Prot:P12011" /translation="MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTA EQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADN RSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEY IFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCS PEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDE KGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQ RVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTV FLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLY ATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRG LITHK*" /label="gntK CDS" gene 3440593..3442134 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /label="gntK gene" CDS 3442163..3443509 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3020045, 15849754, 1659648, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3020045, 15849754, 1659648, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gluconate/proton permease" /protein_id="NP_391887.1" /db_xref="EnsemblGenomes-Gn:BSU40070" /db_xref="EnsemblGenomes-Tr:CAB16044" /db_xref="GOA:P12012" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG10650" /db_xref="UniProtKB/Swiss-Prot:P12012" /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFD KVVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVV IASFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGP TAIAGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQK TFNLEETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAM IISLLVAVYTMGIKRNIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDY VADLFKGTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLA TGAGSVIASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV*" /label="gntP CDS" gene 3442163..3443509 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /label="gntP gene" promotor_-35 3442962..3442966 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3442982..3443001 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3442991 /Source="Nicolas_upshifts" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3443532..3444938 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /EC_number="1.1.1.343" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 9535092, 9931298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 9535092, 9931298; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase (NAD+-dependent)" /protein_id="NP_391888.1" /db_xref="EnsemblGenomes-Gn:BSU40080" /db_xref="EnsemblGenomes-Tr:CAB16045" /db_xref="GOA:P12013" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10651" /db_xref="UniProtKB/Swiss-Prot:P12013" /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQK LDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNS HYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFE TWNQGELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPS TIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYA QGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPY FTDKLHAYQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGA HTYERTDMDGVFHTNWSE*" /label="gntZ CDS" gene 3443532..3444938 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /label="gntZ gene" downshifts 3444927 /Source="Nicolas_upshifts" /id="D2072" /incds=0 /nref=128 /ntot=228 /MaxReadThrough="3.81668" /MaxDrop="5.52642" /score="20.2280166" /energy="-10.2" /TU="NA" /idTUdmin="U3151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3445035..3445054 /Source="Nicolas_upshift_promotors" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3445037..3445328 /Source="Nicolas_S_feature" /locus_tag="new_4118585_4118876" /HighExp="S8, Etha, Sw, T0.30H, Cold, H2O2, B60, S5, S4, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1540" upshifts 3445037 /Source="Nicolas_upshifts" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="upshifts" promotor_-35 3445301..3445308 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3445323..3445342 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3445330 /Source="Nicolas_upshifts" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3445352..3445359 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3445374..3445393 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3445377) /Source="Nicolas_upshifts" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3445380..3445394) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3445389 /Source="Nicolas_upshifts" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3445402..3445406) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3445402..3445965 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /EC_number="1.11.1.5" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932315, 14766928, 26322180" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932315, 14766928, 26322180; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (small subunit)" /protein_id="NP_391889.1" /db_xref="EnsemblGenomes-Gn:BSU40090" /db_xref="EnsemblGenomes-Tr:CAB16046" /db_xref="GOA:P80239" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017559" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11385" /db_xref="UniProtKB/Swiss-Prot:P80239" /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFS FVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQ TISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ NPGEVCPAKWEEGGETLTPSLDLVGKI*" /label="ahpC CDS" gene 3445402..3445965 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /label="ahpC gene" CDS 3445979..3447508 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /EC_number="1.6.99.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932314, 14766928, 16232966, 23899494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932314, 14766928, 16232966, 23899494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (large subunit)" /protein_id="NP_391890.1" /db_xref="EnsemblGenomes-Gn:BSU40100" /db_xref="EnsemblGenomes-Tr:CAB16047" /db_xref="GOA:P42974" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR012081" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11204" /db_xref="UniProtKB/Swiss-Prot:P42974" /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDEL ASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPK VDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKA EVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGP AGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEY DIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGV AYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRL YSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLE GTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIR N*" /label="ahpF CDS" gene 3445979..3447508 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /label="ahpF gene" downshifts complement(3447335) /Source="Nicolas_upshifts" /id="D2073" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="3.25325" /MaxDrop="3.69049" /score="1.76901559" /energy="-18" /TU="NA" /idTUdmin="U3157" /TUdmin=198 /isTUend="FALSE" /label="downshifts" downshifts 3447501 /Source="Nicolas_upshifts" /id="D2074" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="3.92009" /MaxDrop="8.88048" /score="33.1934883" /energy="-19.6" /TU="U3154" /idTUdmin="U3156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3447534..3447617) /Source="Nicolas_S_feature" /locus_tag="new_4121082_4121165_c" /HighExp="G150, C30, LPhT, G135, S8, LBGstat, T0.30H, G180, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1541" downshifts complement(3447577) /Source="Nicolas_upshifts" /id="D2075" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.37922" /MaxDrop="4.44094" /score="1.76901559" /energy="-18" /TU="U3157" /idTUdmin="U3157" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3447618..3449057) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8125345, 14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8125345, 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-6-phospho-beta-glucosidase" /protein_id="NP_391891.1" /db_xref="EnsemblGenomes-Gn:BSU40110" /db_xref="EnsemblGenomes-Tr:CAB16048" /db_xref="GOA:P42973" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11203" /db_xref="UniProtKB/Swiss-Prot:P42973" /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVP RKITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEP NEAGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEAC FTRYKDKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVAS ALAVAKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYP SYALKEFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGG LPNGVENPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKV HDPERIQYLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRD NEGNGSMKRYKKDSFEWYKNVIQTNGEEL*" /label="bglA CDS" gene complement(3447618..3449057) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /label="bglA gene" CDS complement(3449071..3449301) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /EC_number="2.7.1.-" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867744, 28731580" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867744, 28731580; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucose phosphotransferase system enzyme IIA component" /protein_id="NP_391892.1" /db_xref="EnsemblGenomes-Gn:BSU40120" /db_xref="EnsemblGenomes-Tr:CAB16049" /db_xref="GOA:O32292" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG14172" /db_xref="UniProtKB/Swiss-Prot:O32292" /translation="MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT VKKGEVLVEFDKAFIEDIEESALHQKIFTVVS*" /label="ptsJ CDS" gene complement(3449071..3449301) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /label="ptsJ gene" S_feature complement(3449302..3449513) /Source="Nicolas_S_feature" /locus_tag="new_4122850_4123061_c" /HighExp="G150, LPhT, T0.30H, Diami, G135, LBGstat, G180, Oxctl, Lbexp, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1542" promotor_-10 complement(3449510..3449529) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3449515) /Source="Nicolas_upshifts" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3449544..3449551) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3449577..3449584 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3449595..3449614 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3449610 /Source="Nicolas_upshifts" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="upshifts" CDS 3449645..3450355 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_391893.1" /db_xref="EnsemblGenomes-Gn:BSU40130" /db_xref="EnsemblGenomes-Tr:CAB16050" /db_xref="GOA:Q45591" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3BWG" /db_xref="SubtiList:BG11484" /db_xref="UniProtKB/Swiss-Prot:Q45591" /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTIT KSLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVR KPTPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSIFH YIREGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKI SYNYEQSQFVVQANSFLL*" /label="yydK CDS" gene 3449645..3450355 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /label="yydK gene" CDS 3450383..3450541 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097799.1" /db_xref="EnsemblGenomes-Gn:BSU40139" /db_xref="EnsemblGenomes-Tr:CAX52714" /db_xref="GOA:C0H3T8" /db_xref="UniProtKB/Swiss-Prot:C0H3T8" /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFIIFFLF VKMVKEKQ*" /label="yyzN CDS" gene 3450383..3450541 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /label="yyzN gene" downshifts 3450618 /Source="Nicolas_upshifts" /id="D2076" /incds=0 /nref=16 /ntot=177 /MaxReadThrough="0.96913" /MaxDrop="4.2349" /score="-9.95345673" /energy="-14.7" /TU="NA" /idTUdmin="U3158" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3450672..3451394) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /function="16.1: Circulate" /function="16.3: Control" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="permease for export of regulatory peptide LiaD*" /protein_id="NP_391894.1" /db_xref="EnsemblGenomes-Gn:BSU40140" /db_xref="EnsemblGenomes-Tr:CAB16051" /db_xref="GOA:Q45592" /db_xref="SubtiList:BG11483" /db_xref="UniProtKB/Swiss-Prot:Q45592" /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPE MFFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFL ECFAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISVLCPNILISIGVS IVYWMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLV SIIIINAIVLRFSKTRWIKMGL*" /label="liaM CDS" gene complement(3450672..3451394) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /label="liaM gene" downshifts complement(3450684) /Source="Nicolas_upshifts" /id="D2077" /incds=0 /nref=225 /ntot=267 /MaxReadThrough="2.70741" /MaxDrop="6.21099" /score="7.49162587" /energy="-10.5" /TU="NA" /idTUdmin="U3160" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-35 3451295..3451298 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3451314..3451318 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3451329 /Source="Nicolas_upshifts" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3451415..3452044) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter for regulatory peptide LiaD* (ATP-binding protein)" /protein_id="NP_391895.1" /db_xref="EnsemblGenomes-Gn:BSU40150" /db_xref="EnsemblGenomes-Tr:CAB16052" /db_xref="GOA:Q45593" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11482" /db_xref="UniProtKB/Swiss-Prot:Q45593" /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAK DFLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAKMIDKIAYLLNL DNIDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYI QENPEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE*" /label="liaL CDS" gene complement(3451415..3452044) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /label="liaL gene" S_feature complement(3452045..3452193) /Source="Nicolas_S_feature" /locus_tag="new_4125593_4125741_c" /HighExp="T-0.40H, LoTm, T-2.40H, T0.0H, M9-tran, SMMPr, T-1.40H, GM 150, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1543" CDS complement(3452194..3452952) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease acting on modified factor LiaD" /protein_id="NP_391896.2" /db_xref="EnsemblGenomes-Gn:BSU40160" /db_xref="EnsemblGenomes-Tr:CAB16053" /db_xref="GOA:Q45594" /db_xref="SubtiList:BG11481" /db_xref="UniProtKB/Swiss-Prot:Q45594" /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLR FKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMN IVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLF INYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEY SRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN*" /label="liaK CDS" gene complement(3452194..3452952) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /label="liaK gene" promotor_-10 complement(3452642..3452661) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3452658) /Source="Nicolas_upshifts" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3452674..3452681) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3452933..3453892) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /EC_number="5.1.1.-" /experiment="publication(s) with functional evidences, PMID:17921301, 18307109, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17921301, 18307109, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="AdoMet radical amino acid epimerase modifying factor LiaD" /protein_id="NP_391897.1" /db_xref="EnsemblGenomes-Gn:BSU40170" /db_xref="EnsemblGenomes-Tr:CAB16054" /db_xref="GOA:Q45595" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR023904" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG11480" /db_xref="UniProtKB/Swiss-Prot:Q45595" /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTE FAKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFH DMNSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHIL EELGDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGE IYPCCSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKI EEFDIPYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV*" /label="liaE CDS" gene complement(3452933..3453892) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /label="liaE gene" downshifts 3453881 /Source="Nicolas_upshifts" /id="D2078" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.40583" /MaxDrop="2.5017" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3453928..3453931 /Source="Nicolas_upshift_promotors" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3453936 /Source="Nicolas_upshifts" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3453950..3454099) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 17921301, 28644475; Product type r: regulator" /codon_start=1 /transl_table=11 /product="precursor of exported modified peptide (epipeptide) controlling LiaRS activity" /protein_id="NP_391898.1" /db_xref="EnsemblGenomes-Gn:BSU40180" /db_xref="EnsemblGenomes-Tr:CAB16055" /db_xref="InterPro:IPR023898" /db_xref="SubtiList:BG11479" /db_xref="UniProtKB/Swiss-Prot:Q45596" /translation="MKKEITNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWI LGSGH*" /label="liaD CDS" gene complement(3453950..3454099) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /label="liaD gene" downshifts complement(3453957) /Source="Nicolas_upshifts" /id="D2079" /incds=0 /nref=99 /ntot=172 /MaxReadThrough="7.62324" /MaxDrop="6.01674" /score="7.49162587" /energy="-10.5" /TU="U3163" /idTUdmin="U3167" /TUdmin=2794 /isTUend="FALSE" /label="downshifts" misc_feature 3454008..3454025 /Source="Nicolas_upshift_promotors" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3454013 /Source="Nicolas_upshifts" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3454094 /Source="Nicolas_upshifts" /id="D2080" /incds=0 /nref=99 /ntot=170 /MaxReadThrough="2.55247" /MaxDrop="5.95806" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3454120..3454139) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3454141) /Source="Nicolas_upshifts" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3454154..3454161) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3454434..3454441 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3454456..3454475 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3454460 /Source="Nicolas_upshifts" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="upshifts" CDS 3454571..3456496 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /EC_number="3.1.3.11" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:221467, 9696785, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 221467, 9696785, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphatase" /protein_id="NP_391899.2" /db_xref="EnsemblGenomes-Gn:BSU40190" /db_xref="EnsemblGenomes-Tr:CAB16056" /db_xref="GOA:Q45597" /db_xref="InterPro:IPR009164" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11478" /db_xref="UniProtKB/Swiss-Prot:Q45597" /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLH GEYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAK EALNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQY YSEIIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHS VDIQWGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYY DDNPAFRPKADENRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKI DYDKNEITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMN FMMKKGSLYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFA HPEETDDLATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDE ATCRNILAEFGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGI AGYTLLYNSYGMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEEL LQEVAILESLREYRYMK*" /label="fbp CDS" gene 3454571..3456496 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /label="fbp gene" S_feature 3456497..>3456526 /Source="Nicolas_S_feature" /locus_tag="new_4130045_4131409" /HighExp="Lbstat, dia5, C30, Gly, Etha, dia15, C90, Fru, G135, Mal" /AntisenseName="yydD" /AntisenseCor="0.44422072328838003" /AntisenseRegPval="-13.7" /CDS_PredictionProba="0.22050400000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1544" SCAR 3456526..3456527 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs27_025" downshifts 3456536 /Source="Nicolas_upshifts" /id="D2085" /incds=0 /nref=39 /ntot=249 /MaxReadThrough="4.8963" /MaxDrop="7.30713" /score="31.0184314" /energy="-13.7" /TU="U3173,U3176" /idTUdmin="U3173" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3456784..3457674) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /EC_number="3.5.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginase" /protein_id="NP_391912.1" /db_xref="EnsemblGenomes-Gn:BSU40320" /db_xref="EnsemblGenomes-Tr:CAB16069" /db_xref="GOA:P39138" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR014033" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG10932" /db_xref="UniProtKB/Swiss-Prot:P39138" /translation="MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTV EDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIG TLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGV HLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHK NKTGKTAVELVESLLGKKLL*" /label="argI CDS" gene complement(3456784..3457674) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /label="argI gene" downshifts complement(3456790) /Source="Nicolas_upshifts" /id="D2086" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.33097" /MaxDrop="3.38667" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" downshifts complement(3456852) /Source="Nicolas_upshifts" /id="D2087" /incds=1 /nref=28 /ntot=201 /MaxReadThrough="5.16507" /MaxDrop="5.79932" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-151" /isTUend="FALSE" /label="downshifts" CDS complement(3457748..3459151) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7540694, 10648515, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 10648515, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arginine/ornithine/gamma-aminobutyrate permease" /protein_id="NP_391913.1" /db_xref="EnsemblGenomes-Gn:BSU40330" /db_xref="EnsemblGenomes-Tr:CAB16070" /db_xref="GOA:P39137" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10933" /db_xref="UniProtKB/Swiss-Prot:P39137" /translation="MNTNQDNGNQLQRTMKSRHLFMISLGGVIGTGFFLGTGFTINQA GPLGAVLSYLVGGFIMFLTMLCLGELAVAFPVSGSFQTYATKFISPAFGFAFGWLYWL GWAVTCAIEFLSAGQLMQRWFPHIDVWIWCLVFAALMFILNAITTKAFAESEFWFSGI KILIILLFIILGGAAMFGLIDLKGGEQAPFLTHFYEDGLFPNGIKAMLITMITVNFAF QGTELIGVAAGESEDPEKTIPRSIKQTVWRTLVFFVLSIIVIAGMIPWKQAGVVESPF VAVFEQIGIPYAADIMNFVILIALLSVANSGLYASTRILYAMANEGQAFKALGKTNQR GVPMYSLIVTMAVACLSLLTKFAQAETVYMVLLSLAGMSAQVGWITISLSQIMFRRKY IREGGKIEDLKFKTPLYPVLPLIGLTLNTVVLISLAFDPEQRIALYCGVPFMIICYII YHVVIKKRQQANRQLEL*" /label="rocE CDS" gene complement(3457748..3459151) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /label="rocE gene" S_feature complement(3459152..3459373) /Source="Nicolas_S_feature" /locus_tag="new_4144079_4144300_c" /HighExp="Lbstat, S0, LPh, T1.30H, HPh, T2.0H, LPhT, BI, M0t90, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.884" /TUlongSig="NA" /TUlongPSig="NA" /label="S1551" CDS complement(3459374..3460579) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /EC_number="2.6.1.13" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7540694, 9383188, 22720735, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 9383188, 22720735, 23869754; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine aminotransferase" /protein_id="NP_391914.1" /db_xref="EnsemblGenomes-Gn:BSU40340" /db_xref="EnsemblGenomes-Tr:CAB16071" /db_xref="GOA:P38021" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR010164" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR034757" /db_xref="SubtiList:BG10722" /db_xref="UniProtKB/Swiss-Prot:P38021" /translation="MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNE YMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEM ILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAI CKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREI LGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVI KEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIE KIKHVLRNA*" /label="rocD CDS" gene complement(3459374..3460579) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /label="rocD gene" misc_feature complement(3460636..3460654) /Source="Nicolas_upshift_promotors" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3460639) /Source="Nicolas_upshifts" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3460749..3460754 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3460769..3460788 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3460784 /Source="Nicolas_upshifts" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="upshifts" CDS 3460820..3462205 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9194709, 12533460, 12634342, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9194709, 12533460, 12634342, 23869754; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NtrC/NifA family)" /protein_id="NP_391915.1" /db_xref="EnsemblGenomes-Gn:BSU40350" /db_xref="EnsemblGenomes-Tr:CAB16072" /db_xref="GOA:P38022" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG10723" /db_xref="UniProtKB/Swiss-Prot:P38022" /translation="MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIED MEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYP IVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRA TRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKG AFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDV RIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHL FQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKI KPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQY RLKKFSHSSNE*" /label="rocR CDS" gene 3460820..3462205 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /label="rocR gene" CDS complement(3462187..3462375) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17198402; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative sensor protein" /db_xref="PSEUDO:CAX52717.1" /translation="MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIG RGTVFLIRLPAPDYSLDE*" /label="yyzO CDS" gene complement(3462187..3462375) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /pseudo /label="yyzO gene" CDS complement(3462492..3462620) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514013.1" /translation="MPGCFDMQKKLNRGHARSVEKGYIEYEEKYKMDVTRETANGS*" /label="hypothetical protein CDS" gene complement(3462492..3462620) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /label="gene" downshifts 3462544 /Source="Nicolas_upshifts" /id="D2088" /incds=0 /nref=1 /ntot=146 /MaxReadThrough="0.86899" /MaxDrop="2.90385" /score="20.2816165" /energy="-10.8" /TU="NA" /idTUdmin="U3178" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS complement(3462640..3463842) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /EC_number="3.4.21.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 16030236, 25384476" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 16030236, 25384476; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation membrane serine protease" /protein_id="NP_391916.1" /db_xref="EnsemblGenomes-Gn:BSU40360" /db_xref="EnsemblGenomes-Tr:CAB16073" /db_xref="GOA:P39668" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG11054" /db_xref="UniProtKB/Swiss-Prot:P39668" /translation="MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPY LSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWG ESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVD SNGDGQPDWNAEVLQTDAAINPGNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPS KLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAF SPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKL SSADQLGS*" /label="htrC CDS" gene complement(3462640..3463842) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /label="htrC gene" downshifts complement(3462664) /Source="Nicolas_upshifts" /id="D2089" /incds=0 /nref=134 /ntot=253 /MaxReadThrough="2.3073" /MaxDrop="5.06813" /score="5.6507537" /energy="-15" /TU="NA" /idTUdmin="U3179" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3463874..3463885) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3463874) /Source="Nicolas_upshifts" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3463900..3463906) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3463924..3464718) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9829949, 16030236, 21169496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391917.2" /db_xref="EnsemblGenomes-Gn:BSU40370" /db_xref="EnsemblGenomes-Tr:CAB16074" /db_xref="GOA:C0SP91" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11464" /db_xref="UniProtKB/Swiss-Prot:C0SP91" /translation="MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQI GRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFV FPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSA NVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAH LSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV*" /label="walJ CDS" gene complement(3463924..3464718) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /label="walJ gene" CDS complement(3464740..3465582) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 17307848, 17307850, 18408157, 21219466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 17307848, 17307850, 18408157, 21219466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK" /protein_id="NP_391918.1" /db_xref="EnsemblGenomes-Gn:BSU40380" /db_xref="EnsemblGenomes-Tr:CAB16075" /db_xref="GOA:Q45612" /db_xref="InterPro:IPR018604" /db_xref="PDB:2O3O" /db_xref="SubtiList:BG11463" /db_xref="UniProtKB/Swiss-Prot:Q45612" /translation="MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVE HDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLK MKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQK TDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKE YSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTIL DTDQ*" /label="walI CDS" gene complement(3464740..3465582) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /label="walI gene" CDS complement(3465569..3466936) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 16600972, 17307850, 26999783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 16600972, 17307850, 26999783; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK(YycFG)" /protein_id="NP_391919.1" /db_xref="EnsemblGenomes-Gn:BSU40390" /db_xref="EnsemblGenomes-Tr:CAB16076" /db_xref="GOA:Q794W0" /db_xref="InterPro:IPR009996" /db_xref="PDB:2FGT" /db_xref="SubtiList:BG11462" /db_xref="UniProtKB/Swiss-Prot:Q794W0" /modified_by="User" /translation="MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVR VKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISD QYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFN ETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLL PNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYTNRNVLTDGISRLDVNLSQ RQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQ IPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLL SKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGA NSGVE*" /label="Delta6_BSU_40390_SNPvariant" gene complement(3465569..3466936) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /modified_by="User" /label="Delta6_BSU_40390_SNPvariant" Polymorphism join(3466163,3466165) /Source="geneious" /ID="SNP_BsDelta6_4151091_4151091" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="N -> T" /CDS_Position=773 /Change="T -> G" /Codon_Change="AAC -> ACC" /Coverage=184 /locus_tag="BSU_40390" /Protein_Effect="Substitution" /Reference_Frequency="0.5%" /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="Delta6_BSU_40390_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(3466926..3468761) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YycG]" /protein_id="NP_391920.1" /db_xref="EnsemblGenomes-Gn:BSU40400" /db_xref="EnsemblGenomes-Tr:CAB16077" /db_xref="GOA:Q45614" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3SL2" /db_xref="SubtiList:BG11461" /db_xref="UniProtKB/Swiss-Prot:Q45614" /translation="MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISS YEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEV VGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV VGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAM ELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGV IATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEI ERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPL TTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE WIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYS PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGL GLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA*" /label="walK CDS" gene complement(3466926..3468761) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /label="walK gene" CDS complement(3468769..3469476) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YycF]" /protein_id="NP_391921.1" /db_xref="EnsemblGenomes-Gn:BSU40410" /db_xref="EnsemblGenomes-Tr:CAB16078" /db_xref="GOA:P37478" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2D1V" /db_xref="PDB:2ZWM" /db_xref="PDB:3F6P" /db_xref="SubtiList:BG10001" /db_xref="UniProtKB/Swiss-Prot:P37478" /translation="MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEE LQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTK PFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTH REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNW IVTRRGVGYYLRNPEQD*" /label="walR CDS" gene complement(3468769..3469476) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /label="walR gene" S_feature complement(3469477..3469573) /Source="Nicolas_S_feature" /locus_tag="new_4154404_4154500_c" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, dia0, LBGstat, dia5, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="1, 1, 0.11" /TUlongSig="SigA" /TUlongPSig="0.986" /label="S1552" promotor_-10 complement(3469561..3469580) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3469573) /Source="Nicolas_upshifts" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3469575..3469767) /Source="Nicolas_S_feature" /locus_tag="new_4154502_4154694_c" /HighExp="G180, Paraq, Oxctl, G135, G150, H2O2, T0.30H, BMM, Cold, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="0.986, 1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1553" promotor_-35 complement(3469596..3469599) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3469767) /Source="Nicolas_upshifts" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="upshifts" misc_feature complement(3469777..3469796) /Source="Nicolas_upshift_promotors" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3469859) /Source="Nicolas_upshifts" /id="D2090" /incds=0 /nref=8 /ntot=83 /MaxReadThrough="5.21091" /MaxDrop="5.81799" /score="24.1725164" /energy="-10.6" /TU="U3183,U3184" /idTUdmin="U3181" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" tRNA complement(3469860..3469932) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Phe tRNA" gene complement(3469860..3469932) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /label="trnY-Phe gene" tRNA complement(3469968..3470044) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Asp tRNA" gene complement(3469968..3470044) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /label="trnY-Asp gene" S_feature complement(3470045..3470125) /Source="Nicolas_S_feature" /locus_tag="new_4154972_4155052_c" /HighExp="Oxctl, Heat, BMM, Paraq, UNK1, H2O2, C30, MG 45, G180, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1554" tRNA complement(3470126..3470197) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Glu tRNA" gene complement(3470126..3470197) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /label="trnY-Glu gene" tRNA complement(3470207..3470282) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Lys tRNA" gene complement(3470207..3470282) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /label="trnY-Lys gene" misc_feature 3470254..3470270 /Source="Nicolas_upshift_promotors" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3470267 /Source="Nicolas_upshifts" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3470283..3470379) /Source="Nicolas_S_feature" /locus_tag="new_4155210_4155306_c" /HighExp="LBGstat, C30, UNK1, Oxctl, HPh, Heat, MG 150, BMM, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1555" promotor_-10 complement(3470363..3470382) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3470379) /Source="Nicolas_upshifts" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3470396..3470403) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(3470413..3470514) /Source="Nicolas_upshift_promotors" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3470453) /Source="Nicolas_upshifts" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3470507..3471799) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /EC_number="6.3.4.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1312531, 10368157, 16163456, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate synthetase" /protein_id="NP_391922.1" /db_xref="EnsemblGenomes-Gn:BSU40420" /db_xref="EnsemblGenomes-Tr:CAB16079" /db_xref="GOA:P29726" /db_xref="InterPro:IPR001114" /db_xref="InterPro:IPR018220" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033128" /db_xref="SubtiList:BG10002" /db_xref="UniProtKB/Swiss-Prot:P29726" /translation="MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIK FDGITYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRA HVILPYHLKLDEVEEERKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKL ERNLEEKNRLLEKMYETEGFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVL FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGP FPTELKDEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVL AGIETLKICVAYRYKGEIIEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSELPEN ARHYLERVSQLTGIPLSIFSVGPDRSQTNVLRSVYRAN*" /label="purA CDS" gene complement(3470507..3471799) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /label="purA gene" downshifts complement(3470518) /Source="Nicolas_upshifts" /id="D2091" /incds=0 /nref=200 /ntot=241 /MaxReadThrough="2.03104" /MaxDrop="6.53551" /score="13.9967927" /energy="-10.5" /TU="NA" /idTUdmin="U3185" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3471839..3471858) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3471859) /Source="Nicolas_upshifts" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3471873..3471880) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3472005..3472424) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16731985" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391923.1" /db_xref="EnsemblGenomes-Gn:BSU40430" /db_xref="EnsemblGenomes-Tr:CAB16080" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:1TWU" /db_xref="SubtiList:BG10003" /db_xref="UniProtKB/Swiss-Prot:P37479" /translation="MGKRFSSFQAAQIRIARPTGQLDEIIRFYEEGLCLKRIGEFSQH NGYDGVMFGLPHADYHLEFTQYEGGSTAPVPHPDSLLVFYVPNAVELAAITSKLKHMG YQEVESENPYWSNGGVTIEDPDGWRIVFMNSKGISGK*" /label="yycE CDS" gene complement(3472005..3472424) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /label="yycE gene" promotor_-10 complement(3472422..3472433) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3472433) /Source="Nicolas_upshifts" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3472448..3472454) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3472545..3473909) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /EC_number="3.6.4.12" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="NP_391924.2" /db_xref="EnsemblGenomes-Gn:BSU40440" /db_xref="EnsemblGenomes-Tr:CAB16081" /db_xref="GOA:P37469" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036185" /db_xref="SubtiList:BG10004" /db_xref="UniProtKB/Swiss-Prot:P37469" /translation="MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFY RMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANI EYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTA FALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKL TMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDN RQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADI VAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGV PPGA*" /label="dnaC CDS" gene complement(3472545..3473909) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /label="dnaC gene" downshifts complement(3472565) /Source="Nicolas_upshifts" /id="D2092" /incds=0 /nref=3 /ntot=107 /MaxReadThrough="1.37092" /MaxDrop="3.96365" /score="31.6981667" /energy="-12.6" /TU="NA" /idTUdmin="U3187" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3472609) /Source="Nicolas_upshifts" /id="D2093" /incds=1 /nref=9 /ntot=190 /MaxReadThrough="3.89737" /MaxDrop="3.21735" /score="31.6981667" /energy="-12.6" /TU="U3187" /idTUdmin="U3190" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3473940..3473959) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3473954) /Source="Nicolas_upshifts" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3473974..3473976) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3474021..3474027 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-35" promotor_-10 3474042..3474060 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-10" upshifts 3474044 /Source="Nicolas_upshifts" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="upshifts" CDS 3474079..3474279 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391925.1" /db_xref="EnsemblGenomes-Gn:BSU40450" /db_xref="EnsemblGenomes-Tr:CAB16082" /db_xref="InterPro:IPR018691" /db_xref="InterPro:IPR020086" /db_xref="SubtiList:BG10005" /db_xref="UniProtKB/Swiss-Prot:P37480" /translation="MIKKYAITPNVDADGWFIEVENVAPTALYTSKDAAIEKAKQVAK ENSPSKLVIYDQFKNVEEEHSF*" /label="yycD CDS" gene 3474079..3474279 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /label="yycD gene" downshifts 3474249 /Source="Nicolas_upshifts" /id="D2094" /incds=0 /nref=15 /ntot=43 /MaxReadThrough="4.45045" /MaxDrop="5.68737" /score="12.3008592" /energy="-9.5" /TU="U3188" /idTUdmin="U3188" /TUdmin="-352" /isTUend="FALSE" /label="downshifts" S_feature 3474294..3474615 /Source="Nicolas_S_feature" /locus_tag="new_4159220_4159541" /HighExp="Etha, C30, Salt, S6, S8, M9-stat, S7, Oxctl, Paraq, Heat" /AntisenseName="yyzB" /AntisenseCor="0.309580857935493" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1556" CDS complement(3474327..3474530) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391926.1" /db_xref="EnsemblGenomes-Gn:BSU40460" /db_xref="EnsemblGenomes-Tr:CAB16083" /db_xref="SubtiList:BG14171" /db_xref="UniProtKB/Swiss-Prot:O32296" /translation="MHAPLSLLKQMLKEHQIDTEKAVTFEEYIAMRLKLQELMGKFAS IGEWDLYQKAADLMMHIGIQWMK*" /label="yyzB CDS" gene complement(3474327..3474530) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /label="yyzB gene" S_feature complement(3474531..3474831) /Source="Nicolas_S_feature" /locus_tag="new_4159457_4159757_c" /HighExp="S6, S8, S7, S5, S4, BT, B36, T5.0H, S3, C30" /AntisenseName="yycC" /AntisenseCor="-0.77379453158709499" /AntisenseRegPval="-54.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.049" /TUlongSig="NA" /TUlongPSig="NA" /label="S1557" promotor_-35 3474596..3474599 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3474614..3474633 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3474617 /Source="Nicolas_upshifts" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="upshifts" CDS 3474651..3474791 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28546427" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391927.1" /db_xref="EnsemblGenomes-Gn:BSU40470" /db_xref="EnsemblGenomes-Tr:CAB16084" /db_xref="InterPro:IPR025550" /db_xref="SubtiList:BG10006" /db_xref="UniProtKB/Swiss-Prot:P37481" /translation="MRPLQISAETAQKLAESLNLPLEQIMHMPQHILLAKMAELQKED KS*" /label="yycC CDS" gene 3474651..3474791 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /label="yycC gene" S_feature 3474792..3474863 /Source="Nicolas_S_feature" /locus_tag="new_4159718_4159789" /HighExp="Sw, LoTm, Gly, BC, HiOs, B60, S0, T-5.40H, LBGstat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig=1 /label="S1558" upshifts complement(3474839) /Source="Nicolas_upshifts" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3474842..3474856) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3474864..3474868) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3474864..3476072 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25790494; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion ABC transporter (permease)" /protein_id="NP_391928.1" /db_xref="EnsemblGenomes-Gn:BSU40480" /db_xref="EnsemblGenomes-Tr:CAB16085" /db_xref="GOA:P37482" /db_xref="InterPro:IPR004747" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10007" /db_xref="UniProtKB/Swiss-Prot:P37482" /translation="MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELH MSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAA LFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLAT QMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFM GLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRG IVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAA ALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYI FQSEKQRNSA*" /label="yycB CDS" gene 3474864..3476072 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /label="yycB gene" downshifts 3476053 /Source="Nicolas_upshifts" /id="D2095" /incds=0 /nref=148 /ntot=242 /MaxReadThrough="3.65611" /MaxDrop="4.91246" /score="26.443484" /energy="-10.1" /TU="U3189" /idTUdmin="U3189" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 3476177..3478234 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase" /protein_id="NP_391929.2" /db_xref="EnsemblGenomes-Gn:BSU40490" /db_xref="EnsemblGenomes-Tr:CAB16086" /db_xref="GOA:P37483" /db_xref="SubtiList:BG10008" /db_xref="UniProtKB/Swiss-Prot:P37483" /translation="MKTKRFDAALILILLAAAFLNTYHIWQDDTANQYYLAAVKSMTQ SFHNFFYASFDPSGFVTVDKPPVVLWIQTIFALIFGVHTWSVIIPQALAGVGSVFLLY RMVKPTFGVGAARIAALVMALTPIAVAVSRTNNIDSMLVFTLLLGSTCLLRAVKQGKL VWLLTAFALIGLAFNMKMMQAFMVLPAFVLFYLIASRVSLKKKIGSLLLSLVLLTGLS LSWAIAVDSASSSSRPYVGSSQTNSVLELAFGYNGTERLFGQTTGLAKGDMNAAGGGN MQNQDNMQAPNGNGSSFSQNGNQSFGNHSQAPQPPNGQTGALNGGGGTPPTGGNGPGN GGPGGGGGKSVNMFGTGDPGPLRLFQSALSGQISWMLPFSLIGLLGAIISWYRDRRGH AAKMKETLFWAAWLVPVAGFFSIAGFFHQYYLIMLAPPIAALSGIGWYTMHRLYKNNK DWSSYLLPAAVLITAVFQVYILSAYTSQIGSVWMYVLGLLGLGITLALLMLKRSHPFS KLLTIISLCVLLLTPVYWSATPLLYGGNSVLPESGPQLKGSANGGNMFSSEVDSGLLS YLRKHNTGEEYLFATLTTVTAAPYIIYENESVMAMGGFNGTDPILTVSELKKLIKEGK VKYFLLSENNSGNSELVSWIKKNGKEITSDEYSGSSSSTNSVQGMRRGPGGESQQTLY LVE*" /label="yycA CDS" gene 3476177..3478234 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /label="yycA gene" downshifts 3478099 /Source="Nicolas_upshifts" /id="D2096" /incds=1 /nref=43 /ntot=203 /MaxReadThrough="1.96363" /MaxDrop="3.65354" /score="19.8733078" /energy="-16.6" /TU="NA" /idTUdmin="U3189" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(3478271..3478720) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 23002217; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="NP_391930.1" /db_xref="EnsemblGenomes-Gn:BSU40500" /db_xref="EnsemblGenomes-Tr:CAB16087" /db_xref="GOA:P37437" /db_xref="InterPro:IPR000244" /db_xref="InterPro:IPR009027" /db_xref="InterPro:IPR020069" /db_xref="InterPro:IPR020070" /db_xref="InterPro:IPR020594" /db_xref="InterPro:IPR036791" /db_xref="InterPro:IPR036935" /db_xref="SubtiList:BG10009" /db_xref="UniProtKB/Swiss-Prot:P37437" /translation="MKVIFLQDVKGKGKKGEVKNVADGYAHNFLIKKGLAVEANASNI SALNGQKQKEKKEAIAELEQAKSLKETLEKLTVELSAKSGEGGRLFGSVTSKQITEQL QKDHNIKVDKRKLELPDGIRALGYTNVPVKLHPEVQAVLKVHVKEEA*" /label="rplI CDS" gene complement(3478271..3478720) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /label="rplI gene" downshifts complement(3478285) /Source="Nicolas_upshifts" /id="D2097" /incds=0 /nref=231 /ntot=266 /MaxReadThrough="2.69721" /MaxDrop="6.57383" /score="44.1169256" /energy="-16.6" /TU="NA" /idTUdmin="U3191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3478717..3480696) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /EC_number="3.1.4.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphodiesterase acting on cyclic dinucleotides" /protein_id="NP_391931.1" /db_xref="EnsemblGenomes-Gn:BSU40510" /db_xref="EnsemblGenomes-Tr:CAB16088" /db_xref="GOA:P37484" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR014528" /db_xref="SubtiList:BG10010" /db_xref="UniProtKB/Swiss-Prot:P37484" /translation="MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLA VILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPF LSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDV TEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIF LKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKE LGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIV TESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKK YEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEE FIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTG SRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEE EYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGG HLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR*" /label="gdpP CDS" gene complement(3478717..3480696) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /label="gdpP gene" misc_feature complement(3479198..3479217) /Source="Nicolas_upshift_promotors" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3479201) /Source="Nicolas_upshifts" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3479614..3479621 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3479635..3479653 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3479639..3480305 /Source="Nicolas_S_feature" /locus_tag="new_4164565_4165231" /HighExp="LBGstat, C30, Cold, GM 10, GM 25, GM 15, GM-0.1, GM 45, GM 120, GM 90" /AntisenseName="yybT" /AntisenseCor="0.145393098609886" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1559" upshifts 3479639 /Source="Nicolas_upshifts" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3480733..3481662) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22956758; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391932.1" /db_xref="EnsemblGenomes-Gn:BSU40520" /db_xref="EnsemblGenomes-Tr:CAB16089" /db_xref="InterPro:IPR018710" /db_xref="SubtiList:BG10011" /db_xref="UniProtKB/Swiss-Prot:P37485" /translation="MKQTRALMEGAILISLFAIITLLVVYVPVIGTILLFALPLPMIL YTIRHGLKLGIWMGAVSLPVVFIVGSFNGLIVAFMSACAGIAMGHFFKRKEPGHAIIS GALIYMLSIVFYFVISIQFLGINIIDEAMTQYRQSLDIVETVAKQSGNAGQFEKQLKL MEEQLGIVQYLFPTAIVMVGVIFSFLSYLIAKPLLRRFSPDIPNLKPFRELKFPQSVV VLYLIIVMLSFLPLEKGQMLYSIALNGEFILGFLIFIQGLSFIFFYCHKKQYPKAAAV IAVILGFVHPVFMAAIRILGVLDMGFHIRNKVK*" /label="yybS CDS" gene complement(3480733..3481662) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /label="yybS gene" S_feature complement(3481663..3481799) /Source="Nicolas_S_feature" /locus_tag="new_4166589_4166725_c" /HighExp="H2O2, G150, G180, Cold, Paraq, G135, Oxctl, Salt, Etha, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1560" promotor_-10 complement(3481781..3481800) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3481799) /Source="Nicolas_upshifts" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3481815..3481820) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3481889..3482038) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097802.1" /db_xref="EnsemblGenomes-Gn:BSU40529" /db_xref="EnsemblGenomes-Tr:CAX52718" /db_xref="GOA:C0H3U2" /db_xref="UniProtKB/Swiss-Prot:C0H3U2" /translation="MWDMIKNFFLFSSGVLQATTLLLVILIFMYVRKTKKKNKESSGF MDDKH*" /label="yyzH CDS" gene complement(3481889..3482038) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /label="yyzH gene" downshifts complement(3481915) /Source="Nicolas_upshifts" /id="D2098" /incds=0 /nref=1 /ntot=44 /MaxReadThrough="6.98636" /MaxDrop="3.23568" /score="-6.7107279" /energy="-8.4" /TU="U3194" /idTUdmin="U3197" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3482077..3482096) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-10" upshifts complement(3482094) /Source="Nicolas_upshifts" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="upshifts" promotor_-35 complement(3482110..3482116) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-35" promotor_-35 3482117..3482126 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3482139..3482158 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3482145 /Source="Nicolas_upshifts" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3482157) /Source="Nicolas_upshifts" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3482159..3482672) /Source="Nicolas_S_feature" /locus_tag="new_4167085_4167598_c" /HighExp="dia5, Diami, H2O2, Salt, dia15, Etha, Paraq, LPhT, G180, C30" /AntisenseName="cotF" /AntisenseCor="-0.33406696665100499" /AntisenseRegPval="-7.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1561" promotor_-10 complement(3482161..3482175) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3482184..3482188) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3482184..3482666 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1708381, 19933362, 23335421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1708381, 19933362, 23335421; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_391933.1" /db_xref="EnsemblGenomes-Gn:BSU40530" /db_xref="EnsemblGenomes-Tr:CAB16090" /db_xref="GOA:P23261" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="InterPro:IPR016493" /db_xref="SubtiList:BG10012" /db_xref="UniProtKB/Swiss-Prot:P23261" /translation="MDERRTLAWHETLEMHELVAFQSNGLIKLKKMIREVKDPQLRQL YNVSIQGVEQNLRELLPFFPQAPHREDEEEERADNPFYSGDLLGFAKTSVRSYAIAIT ETATPQLRNVLVKQLNAAIQLHAQVYRYMYQHGYYPSYNLSELLKNDVRNANRAISMK *" /label="cotF CDS" gene 3482184..3482666 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /label="cotF gene" downshifts 3482653 /Source="Nicolas_upshifts" /id="D2099" /incds=0 /nref=20 /ntot=52 /MaxReadThrough="5.45774" /MaxDrop="4.1869" /score="-3.60126456" /energy="-16.9" /TU="U3195" /idTUdmin="U3195" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3482696..3483073) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22238377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22238377; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Cys-activated by oxidative stress)" /protein_id="NP_391934.1" /db_xref="EnsemblGenomes-Gn:BSU40540" /db_xref="EnsemblGenomes-Tr:CAB16091" /db_xref="GOA:P37486" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4A5M" /db_xref="PDB:4A5N" /db_xref="SubtiList:BG10013" /db_xref="UniProtKB/Swiss-Prot:P37486" /translation="MSEKKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNE FRRICPSITQRMLTLQLRELEADGIVHREVYHQVPPKVEYSLTEFGRTLEPIVLQMKE WGESNRDVLESYRSNGLVKDQQK*" /label="hypR CDS" gene complement(3482696..3483073) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /label="hypR gene" S_feature 3482698..3483227 /Source="Nicolas_S_feature" /locus_tag="new_4167624_4168153" /HighExp="S8, S6, S7, BT, S5, B36, C30, B60, G/S, Pyr" /AntisenseName="yybR" /AntisenseCor="-0.26586375565089998" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1562" downshifts complement(3482717) /Source="Nicolas_upshifts" /id="D2100" /incds=0 /nref=124 /ntot=240 /MaxReadThrough="4.32896" /MaxDrop="5.38963" /score="10.6464065" /energy="-15.3" /TU="U3197" /idTUdmin="U3197" /TUdmin="-802" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3483128..3483147) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3483140) /Source="Nicolas_upshifts" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3483161..3483168) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3483209..3483213 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3483227..3483246 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3483229 /Source="Nicolas_upshifts" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3483254..3483268) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3483257) /Source="Nicolas_upshifts" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3483278..3484207 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /EC_number="3.6.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic pyrophosphatase (Mn2+-dependent)" /protein_id="NP_391935.1" /db_xref="EnsemblGenomes-Gn:BSU40550" /db_xref="EnsemblGenomes-Tr:CAB16092" /db_xref="GOA:P37487" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR004097" /db_xref="InterPro:IPR022934" /db_xref="PDB:1K23" /db_xref="PDB:1WPM" /db_xref="PDB:1WPN" /db_xref="PDB:2HAW" /db_xref="PDB:2IW4" /db_xref="SubtiList:BG10014" /db_xref="UniProtKB/Swiss-Prot:P37487" /translation="MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNG ETQYALDYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIAN FETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTD QDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQ VNTVDIEDVKKRQAELEAVISKVVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEK AFNVTLENNTALLKGVVSRKKQVVPVLTDAMAE*" /label="ppaC CDS" gene 3483278..3484207 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /label="ppaC gene" downshifts 3484193 /Source="Nicolas_upshifts" /id="D2101" /incds=0 /nref=235 /ntot=270 /MaxReadThrough="2.06965" /MaxDrop="8.02492" /score="25.8885382" /energy="-11.7" /TU="NA" /idTUdmin="U3195" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 3484209..3484210 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_014" CDS complement(3484212..3484766) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /EC_number="2.3.1.79" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12731863, 12793527, 19087206, 22226636, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose O-acetyltransferase" /protein_id="NP_391965.1" /db_xref="EnsemblGenomes-Gn:BSU40850" /db_xref="EnsemblGenomes-Tr:CAB16122" /db_xref="GOA:P37515" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR024688" /db_xref="SubtiList:BG10043" /db_xref="UniProtKB/Swiss-Prot:P37515" /translation="MLRTEKEKMAAGELYNSEDQQLLLERKHARQLIRQYNETPEDDA VRTKLLKELLGSVGDQVTILPTFRCDYGYHIHIGDHTFVNFDCVILDVCEVRIGCHCL IAPGVHIYTAGHPLDPIERKSGKEFGKPVTIGDQVWIGGRAVINPGVTIGDNAVIASG SVVTKDVPANTVVGGNPARILKQL*" /label="maa CDS" gene complement(3484212..3484766) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /label="maa gene" CDS complement(3484784..3485164) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19087206; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_391966.1" /db_xref="EnsemblGenomes-Gn:BSU40860" /db_xref="EnsemblGenomes-Tr:CAB16123" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10044" /db_xref="UniProtKB/Swiss-Prot:P37516" /translation="MQIEHTAVWVNDLERMKSFYESYFNGEANDLYHNEKKDFKSYFI TFDSGARLEIMKKGNVTDPPSQTMTGWAHIAFSVGSREKVDELTDRLKADGFAVVNGP RTTGDGYYESVIEDDEGNLIEITI*" /label="yyaH CDS" gene complement(3484784..3485164) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /label="yyaH gene" CDS complement(3485220..3486155) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9457849, 9642180, 16267306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457849, 9642180, 16267306; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of carbon supply (LacIfamily)" /protein_id="NP_391967.1" /db_xref="EnsemblGenomes-Gn:BSU40870" /db_xref="EnsemblGenomes-Tr:CAB16124" /db_xref="GOA:P37517" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10045" /db_xref="UniProtKB/Swiss-Prot:P37517" /translation="MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELD YTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPD IEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKT AYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMN DGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFP SLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA*" /label="ccpB CDS" gene complement(3485220..3486155) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /label="ccpB gene" promotor_-35 3486145..3486154 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3486168..3486187 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3486175 /Source="Nicolas_upshifts" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3486199..3486218) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3486213) /Source="Nicolas_upshifts" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3486214..3486972) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /EC_number="3.1.11.2" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10540738, 16237020, 18203828, 21441501, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10540738, 16237020, 18203828, 21441501, 24244006, 24914186; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="apurinic/apyrimidinic endonuclease" /protein_id="NP_391968.1" /db_xref="EnsemblGenomes-Gn:BSU40880" /db_xref="EnsemblGenomes-Tr:CAB16125" /db_xref="GOA:P37454" /db_xref="InterPro:IPR004808" /db_xref="InterPro:IPR005135" /db_xref="InterPro:IPR020847" /db_xref="InterPro:IPR020848" /db_xref="InterPro:IPR036691" /db_xref="PDB:5CFE" /db_xref="SubtiList:BG10046" /db_xref="UniProtKB/Swiss-Prot:P37454" /translation="MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQV DLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFV MTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKA NRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDY FVVSESLKEQIEDASISADVMGSDHCPVELIINI*" /label="exoA CDS" gene complement(3486214..3486972) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /label="exoA gene" promotor_-35 complement(3486231..3486238) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3486505..3487008 /Source="Nicolas_S_feature" /locus_tag="new_4198071_4198574" /HighExp="C30, S8, S7, S6, BT, S5, M/G, Glucon, C90, T1.0H" /AntisenseName="exoAA" /AntisenseCor="-0.177921457862244" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1574" downshifts 3486967 /Source="Nicolas_upshifts" /id="D2118" /incds=0 /nref=2 /ntot=12 /MaxReadThrough="2.65789" /MaxDrop="4.11352" /score="16.4680636" /energy="-6.8" /TU="NA" /idTUdmin="U3224" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS complement(3487037..3487276) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 22720735, 24310371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 22720735, 24310371; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S18" /protein_id="NP_391969.2" /db_xref="EnsemblGenomes-Gn:BSU40890" /db_xref="EnsemblGenomes-Tr:CAB16126" /db_xref="GOA:P21475" /db_xref="InterPro:IPR001648" /db_xref="InterPro:IPR018275" /db_xref="InterPro:IPR036870" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10047" /db_xref="UniProtKB/Swiss-Prot:P21475" /translation="MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKI LPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE*" /label="rpsR CDS" gene complement(3487037..3487276) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /label="rpsR gene" downshifts complement(3487043) /Source="Nicolas_upshifts" /id="D2119" /incds=0 /nref=217 /ntot=268 /MaxReadThrough="4.97781" /MaxDrop="7.46952" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227" /idTUdmin="U3229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3487111) /Source="Nicolas_upshifts" /id="D2120" /incds=1 /nref=13 /ntot=142 /MaxReadThrough="8.89363" /MaxDrop="3.9797" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227,U3229" /idTUdmin="U3229" /TUdmin="-68" /isTUend="FALSE" /label="downshifts" CDS complement(3487320..3487838) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391970.1" /db_xref="EnsemblGenomes-Gn:BSU40900" /db_xref="EnsemblGenomes-Tr:CAB16127" /db_xref="GOA:P37455" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10048" /db_xref="UniProtKB/Swiss-Prot:P37455" /translation="MLNRVVLVGRLTKDPELRYTPNGAAVATFTLAVNRTFTNQSGER EADFINCVTWRRQAENVANFLKKGSLAGVDGRLQTRNYENQQGQRVFVTEVQAESVQF LEPKNGGGSGSGGYNEGNSGGGQYFGGGQNDNPFGGNQNNQRRNQGNSFNDDPFANDG KPIDISDDDLPF*" /label="ssbA CDS" gene complement(3487320..3487838) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /label="ssbA gene" CDS complement(3487879..3488166) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 19653700, 26447183" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 19653700, 26447183; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S6 (BS9)" /protein_id="NP_391971.1" /db_xref="EnsemblGenomes-Gn:BSU40910" /db_xref="EnsemblGenomes-Tr:CAB16128" /db_xref="GOA:P21468" /db_xref="InterPro:IPR000529" /db_xref="InterPro:IPR014717" /db_xref="InterPro:IPR020814" /db_xref="InterPro:IPR020815" /db_xref="InterPro:IPR035980" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10049" /db_xref="UniProtKB/Swiss-Prot:P21468" /translation="MRKYEVMYIIRPNIDEESKKAVIERFNNVLTSNGAEITGTKDWG KRRLAYEINDFRDGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEE*" /label="rpsF CDS" gene complement(3487879..3488166) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /label="rpsF gene" S_feature complement(3488167..3488233) /Source="Nicolas_S_feature" /locus_tag="new_4199733_4199799_c" /HighExp="MG t5, LPhT, GM 90, SMM, T-5.40H, GM-0.2, MG 150, GM 45, Gly, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.993, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1575" promotor_-10 complement(3488232..3488251) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3488233) /Source="Nicolas_upshifts" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3488265..3488270) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3488277..3489377) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12837776, 16014871, 18713637, 21527254, 22995830, 26018081, 26160547, 26912459; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent informational ATPase interacting with 70S ribosome; ROS stress regulator" /protein_id="NP_391972.1" /db_xref="EnsemblGenomes-Gn:BSU40920" /db_xref="EnsemblGenomes-Tr:CAB16129" /db_xref="GOA:P37518" /db_xref="InterPro:IPR004396" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR013029" /db_xref="InterPro:IPR023192" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="SubtiList:BG10050" /db_xref="UniProtKB/Swiss-Prot:P37518" /translation="MALTAGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGIV EVPDDRLQKLTELVNPKKTVPTAFEFTDIAGIVKGASKGEGLGNKFLSHIRQVDAICH VVRAFSDDNITHVSGKVDPIDDIETINLELILADMETVEKRITRVSKLAKQKDKDAVF EFEILSKLKEAFESEKPARSVEFTEEQQKLVKQLHLLTSKPILYVANVSEDEVADPSG NENVAKIREYAAGENAEVIVVCAKIESEIAELEGEEKQMFLEELGIQESGLDQLIKAS YSLLGLATYFTAGEQEVRAWTFKKGMKAPECAGIIHSDFERGFIRAETVAYEDLLAGG GMAGAKEAGKVRLEGKEYVVQDGDVIHFRFNV*" /label="engD CDS" gene complement(3488277..3489377) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /label="engD gene" promotor_-10 complement(3489425..3489444) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-10" upshifts complement(3489440) /Source="Nicolas_upshifts" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="upshifts" promotor_-35 complement(3489459..3489466) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-35" CDS complement(3489504..3491507) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /EC_number="1.-.-.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17114254, 20817769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (molybdoenzyme)" /protein_id="NP_391973.1" /db_xref="EnsemblGenomes-Gn:BSU40930" /db_xref="EnsemblGenomes-Tr:CAB16130" /db_xref="GOA:P37519" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG10051" /db_xref="UniProtKB/Swiss-Prot:P37519" /translation="MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKI CGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLH SHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNS KHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGW LAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAG LYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAK TKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEK VPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKS DSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPW DDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQR SNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAK TINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA*" /label="yyaE CDS" gene complement(3489504..3491507) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /label="yyaE gene" CDS complement(3491558..3491764) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21348639, 22333191, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="YP_003097803.1" /db_xref="EnsemblGenomes-Gn:BSU40939" /db_xref="EnsemblGenomes-Tr:CAX52723" /db_xref="InterPro:IPR009296" /db_xref="UniProtKB/Swiss-Prot:C0H3V8" /translation="MADKDFGLNDIVEMKKPHPCGANSWKIIRMGMDIRIKCEGCSHS VMIPRREFERKLKKVLVKHEEPTS*" /label="yyzM CDS" gene complement(3491558..3491764) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /label="yyzM gene" promotor_-10 complement(3491726..3491745) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3491751) /Source="Nicolas_upshifts" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3491760..3491766) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3491790..3491809) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-10" upshifts complement(3491801) /Source="Nicolas_upshifts" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="upshifts" promotor_-35 complement(3491826..3491830) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-35" CDS complement(3491858..3492874) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16847258, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391974.1" /db_xref="EnsemblGenomes-Gn:BSU40940" /db_xref="EnsemblGenomes-Tr:CAB16131" /db_xref="SubtiList:BG10052" /db_xref="UniProtKB/Swiss-Prot:P37520" /translation="MLWRAGMKWMLLILGSLIGAGYASGQEIWQFFGAESGLAIVLFT IMFIFSSYIVMKISFKVQSTHFLPVLEHLMGPWLAKIYDVLIIFYLFSTTMVMIAGGG VTLQMYKLPFWWGITLICIVTVCLFLWDVKGILSINSILIPVLVAGLLYALISFQSTH HHTWTIDLSQQYNWPASITFTSLNILSVVAILSSVGKEMKGLGEAKIASVASGLIFGV ISFVYNETLVELAGSLSQFEIPLFAVLEGAPYFLFLCMTAVLCLAIYTTTVAGLLGLS SRLMAFIHMPRWMIVLILLVLMVPFTSFGFSDLIAFLYPIYGMLNLYLLVCLLLYPIL SKWK*" /label="yyaD CDS" gene complement(3491858..3492874) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /label="yyaD gene" promotor_-10 complement(3492907..3492925) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3492919) /Source="Nicolas_upshifts" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3492941..3492946) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3493050) /Source="Nicolas_upshifts" /id="D2121" /incds=0 /nref=32 /ntot=184 /MaxReadThrough="1.8976" /MaxDrop="3.72136" /score="9.09987016" /energy="-7.4" /TU="NA" /idTUdmin="U3230" /TUdmin="-397" /isTUend="FALSE" /label="downshifts" promotor_-35 3493234..3493239 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3493252..3493333 /Source="Nicolas_S_feature" /locus_tag="new_4204818_4204899" /HighExp="S4, S5, S3, S6, LoTm, S7, T5.0H, BT, M9-stat, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1576" upshifts 3493252 /Source="Nicolas_upshifts" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3493255..3493273 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3493334..3493951 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 26362088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore-specific protease" /protein_id="NP_391975.1" /db_xref="EnsemblGenomes-Gn:BSU40950" /db_xref="EnsemblGenomes-Tr:CAB16132" /db_xref="InterPro:IPR009665" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10053" /db_xref="UniProtKB/Swiss-Prot:P37521" /translation="MNRKGGLFSSQERVKQYVSHTDAAAAKQIQTILSSSLRKAAGKP IVVVCIGTDRSTGDSLGPLVGMKLKQMQLTRFHVYGTLSDPVHAVNMKDKINDIHKLH KNPFVIAVDACLGRVKSVGSFQIGDGPLKPGAGVQKDLPEVGDLHINGIVNVSGFMEY FVLQNTRLNLVMNMANVLAEGLSLTDRTEWRQERLNPLQRLTGRI*" /label="sprC CDS" gene 3493334..3493951 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /label="sprC gene" promotor_-35 3493922..3493930 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3493941 /Source="Nicolas_upshifts" /id="D2122" /incds=0 /nref=11 /ntot=30 /MaxReadThrough="2.64888" /MaxDrop="3.74502" /score="0.352922387" /energy="-6.6" /TU="NA" /idTUdmin="U3231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 3493944..3493962 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3493963 /Source="Nicolas_upshifts" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3493990..3494838) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103; Product type f: factor" /codon_start=1 /transl_table=11 /product="site-specific DNA-binding protein" /protein_id="NP_391976.1" /db_xref="EnsemblGenomes-Gn:BSU40960" /db_xref="EnsemblGenomes-Tr:CAB16133" /db_xref="GOA:P26497" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10054" /db_xref="UniProtKB/Swiss-Prot:P26497" /translation="MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDD EALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEA LMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLT LPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQN VPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILEL LSERES*" /label="parB CDS" gene complement(3493990..3494838) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /label="parB gene" downshifts complement(3494010) /Source="Nicolas_upshifts" /id="D2123" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="3.01094" /MaxDrop="5.3801" /score="9.82080496" /energy="-7.9" /TU="U3233" /idTUdmin="U3233" /TUdmin="-257" /isTUend="FALSE" /label="downshifts" CDS complement(3494831..3495592) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome partitioning protein; transcriptionalregulator" /protein_id="NP_391977.1" /db_xref="EnsemblGenomes-Gn:BSU40970" /db_xref="EnsemblGenomes-Tr:CAB16134" /db_xref="GOA:P37522" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10055" /db_xref="UniProtKB/Swiss-Prot:P37522" /translation="MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGN ATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTI SREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQ LLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVR LSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG*" /label="parA CDS" gene complement(3494831..3495592) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /label="parA gene" misc_feature complement(3495626..3495645) /Source="Nicolas_upshift_promotors" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3495644) /Source="Nicolas_upshifts" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3495736) /Source="Nicolas_upshifts" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="upshifts" promotor_-10 complement(3495739..3495747) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-10" promotor_-35 complement(3495761..3495769) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-35" promotor_-35 3495773..3495781 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3495789 /Source="Nicolas_upshifts" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3495793..3495811 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3495840..3496280 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25651892; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative antibiotic immunity protein" /protein_id="NP_391978.2" /db_xref="EnsemblGenomes-Gn:BSU40980" /db_xref="EnsemblGenomes-Tr:CAB16135" /db_xref="GOA:P37523" /db_xref="InterPro:IPR009589" /db_xref="SubtiList:BG10056" /db_xref="UniProtKB/Swiss-Prot:P37523" /translation="MVYQTKRDVPVTLMIVFLILLIQADAIVPFVLGNMRVSGWIIFI LLTLLNGLIIWSFIDLKYVLKEHHLIIKAGLIKHQIPYENIDKVVQKKKLWSGFRLIG SRHAITIYYQGGWGHAVISPQKSEEFIHKLKEKNSNIIIFTKSK*" /label="yyaB CDS" gene 3495840..3496280 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /label="yyaB gene" downshifts 3496229 /Source="Nicolas_upshifts" /id="D2124" /incds=0 /nref=3 /ntot=144 /MaxReadThrough="2.25356" /MaxDrop="3.41185" /score="-0.6683508" /energy="-14.5" /TU="NA" /idTUdmin="U3235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3496331..3497182) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /function="16.13: Shape" /function="16.8: Protect" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11807071, 15210112, 16549676, 25568309, 28500529" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807071, 15210112, 16549676, 25568309, 28500529; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-binding protein Spo0J-like" /protein_id="NP_391979.1" /db_xref="EnsemblGenomes-Gn:BSU40990" /db_xref="EnsemblGenomes-Tr:CAB16136" /db_xref="GOA:P37524" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR023705" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10057" /db_xref="UniProtKB/Swiss-Prot:P37524" /translation="MKHSFSRFFGLGEKEQEPEIAEHDTNKEEILEIPVNAIVPNRFQ PRTIFSDEKIKELAMTIHTHGIIQPIVVRHTEEEGQYELIAGERRWRAVQSLEWEKIP AIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQST IANKLRLLKLPQPVQEAIMEKKITERHARALIPLKQPELQVTLLTEIIEKSLNVKQTE DRVVKMLEQGQRKPKPRRKAFSRDTRIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQ LTIRIPK*" /label="nocA CDS" gene complement(3496331..3497182) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /label="nocA gene" downshifts complement(3496350) /Source="Nicolas_upshifts" /id="D2125" /incds=0 /nref=245 /ntot=265 /MaxReadThrough="2.30868" /MaxDrop="6.68899" /score="29.5496038" /energy="-14.5" /TU="NA" /idTUdmin="U3236" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(3497183..3497303) /Source="Nicolas_S_feature" /locus_tag="new_4208749_4208869_c" /HighExp="LBGstat, G135, G180, H2O2, dia15, G150, Paraq, T0.30H, Oxctl, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1577" CDS complement(3497304..3498023) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /EC_number="2.1.1.170" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12001236, 17238915, 17573471, 19622680, 24509311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12001236, 17238915, 17573471, 19622680, 24509311; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-methylguanosine methyltransferase (16S rRNA, nucleotide G527)" /protein_id="NP_391980.1" /db_xref="EnsemblGenomes-Gn:BSU41000" /db_xref="EnsemblGenomes-Tr:CAB16137" /db_xref="GOA:P25813" /db_xref="InterPro:IPR003682" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XDZ" /db_xref="SubtiList:BG10058" /db_xref="UniProtKB/Swiss-Prot:P25813" /translation="MNIEEFTSGLAEKGISLSPRQLEQFELYYDMLVEWNEKINLTSI TEKKEVYLKHFYDSITAAFYVDFNQVNTICDVGAGAGFPSLPIKICFPHLHVTIVDSL NKRITFLEKLSEALQLENTTFCHDRAETFGQRKDVRESYDIVTARAVARLSVLSELCL PLVKKNGLFVALKAASAEEELNAGKKAITTLGGELENIHSFKLPIEESDRNIMVIRKI KNTPKKYPRKPGTPNKSPIEG*" /label="rsmG CDS" gene complement(3497304..3498023) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /label="rsmG gene" CDS complement(3498037..3499923) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11914360, 14993678, 17062623, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA uridine 5-carboxymethylaminomethyl modification enzyme" /protein_id="NP_391981.1" /db_xref="EnsemblGenomes-Gn:BSU41010" /db_xref="EnsemblGenomes-Tr:CAB16138" /db_xref="GOA:P25812" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004416" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR026904" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10059" /db_xref="UniProtKB/Swiss-Prot:P25812" /translation="MGYEAGQYDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVA FMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADK FQYQHEMKNTLEKEPNLTLLQGIVERLIVEDGECRGVITQTGAHYRAKAVVMTTGTYL RGRIILGDLSYSSGPNNQQPSIKLSEHLEELGFDLVRFKTGTPPRVKSDTIDYSKTEI QPGDDVPRAFSYETVEYITDQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGTGPRY CPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQQRMLATIPGLENV QMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAG RKALGKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTE IGHRIGLISDERYAAFEKKKAAIEAEKKRLHSVIIKPSPENQEYIRSLGGSELKDGVR GTDLMKRPEMNYETVTKLAPPEVPVPQDVAEQVEIQVKYEGYIEKSLQQVEKLKKMEN KKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGRIA KIAE*" /label="trmF CDS" gene complement(3498037..3499923) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /label="trmF gene" CDS complement(3499944..3501323) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /EC_number="3.6.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15522079, 15616586, 19052377, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA modification GTPase and tRNA-U34 5-formylation enzyme" /protein_id="NP_391982.1" /db_xref="EnsemblGenomes-Gn:BSU41020" /db_xref="EnsemblGenomes-Tr:CAB16139" /db_xref="GOA:P25811" /db_xref="InterPro:IPR004520" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR018948" /db_xref="InterPro:IPR025867" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031168" /db_xref="SubtiList:BG10060" /db_xref="UniProtKB/Swiss-Prot:P25811" /translation="MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSS VESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLA LREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALV RRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKIL REGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDT AGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVIL NKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYV SNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQ LFSQFCLGK*" /label="mnmE CDS" gene complement(3499944..3501323) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /label="mnmE gene" S_feature complement(3501324..3501454) /Source="Nicolas_S_feature" /locus_tag="new_4212890_4213020_c" /HighExp="dia15, Diami, LBGstat, H2O2, Paraq, dia5, G180, T0.30H, LBGexp, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1578" promotor_-10 complement(3501446..3501465) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3501454) /Source="Nicolas_upshifts" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3501481..3501485) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3501509..3501528) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-10" upshifts complement(3501519) /Source="Nicolas_upshifts" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="upshifts" promotor_-35 complement(3501542..3501549) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-35" promotor_-35 3501609..3501615 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3501620..3503905 /Source="Nicolas_S_feature" /locus_tag="new_4213186_4215471" /HighExp="T0.30H, C30, T1.0H, T1.30H, S2, T0.0H, T-1.10H, T-0.40H, T-1.40H, C90" /AntisenseName="oxaAA" /AntisenseCor="-0.20593684080740801" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.685" /TUlongSig="NA" /TUlongPSig="NA" /label="S1579" upshifts 3501620 /Source="Nicolas_upshifts" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3501630..3501649 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3501634..3502260) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1487728, 12813085, 26883633, 27776484; Product type f: factor" /codon_start=1 /transl_table=11 /product="SpoIIIJ-associated RNA/ssDNA-binding protein" /protein_id="NP_391983.1" /db_xref="EnsemblGenomes-Gn:BSU41030" /db_xref="EnsemblGenomes-Tr:CAB16140" /db_xref="GOA:Q01620" /db_xref="InterPro:IPR001374" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR032782" /db_xref="InterPro:IPR034079" /db_xref="InterPro:IPR036867" /db_xref="SubtiList:BG10061" /db_xref="UniProtKB/Swiss-Prot:Q01620" /translation="MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGI FGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALL IGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKT KKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR*" /label="jag CDS" gene complement(3501634..3502260) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /label="jag gene" downshifts complement(3501651) /Source="Nicolas_upshifts" /id="D2126" /incds=0 /nref=229 /ntot=258 /MaxReadThrough="2.29192" /MaxDrop="6.32351" /score="24.2602773" /energy="-14.1" /TU="NA" /idTUdmin="U3239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3502257..3503042) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_391984.1" /db_xref="EnsemblGenomes-Gn:BSU41040" /db_xref="EnsemblGenomes-Tr:CAB16141" /db_xref="GOA:Q01625" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG10062" /db_xref="UniProtKB/Swiss-Prot:Q01625" /translation="MLLKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVY PLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKE KYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEH SFLWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAI NFPAALSLYWVVGNLFMIAQTFLIKGPDIKKNPEPQKAGGKKK*" /label="oxaAA CDS" gene complement(3502257..3503042) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /label="oxaAA gene" promotor_-10 complement(3503087..3503106) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3503099) /Source="Nicolas_upshifts" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3503101..3503186) /Source="Nicolas_S_feature" /locus_tag="new_4214667_4214752_c" /HighExp="G135, G180, H2O2, Oxctl, Paraq, G150, Cold, LPh, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1580" promotor_-35 complement(3503118..3503124) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3503187..3503537) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /EC_number="3.1.26.5" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein component of ribonuclease P (RNase P) (substrate specificity)" /protein_id="NP_391985.1" /db_xref="EnsemblGenomes-Gn:BSU41050" /db_xref="EnsemblGenomes-Tr:CAB16142" /db_xref="GOA:P25814" /db_xref="InterPro:IPR000100" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020539" /db_xref="InterPro:IPR020568" /db_xref="PDB:1A6F" /db_xref="PDB:4JG4" /db_xref="SubtiList:BG10063" /db_xref="UniProtKB/Swiss-Prot:P25814" /translation="MKKRNRLKKNEDFQKVFKHGTSVANRQFVLYTLDQPENDELRVG LSVSKKIGNAVMRNRIKRLIRQAFLEEKERLKEKDYIIIARKPASQLTYEETKKSLQH LFRKSSLYKKSSSK*" /label="rnpA CDS" gene complement(3503187..3503537) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /label="rnpA gene" S_feature complement(3503538..3503688) /Source="Nicolas_S_feature" /locus_tag="new_4215104_4215254_c" /HighExp="G135, G180, Oxctl, H2O2, Paraq, Cold, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1581" CDS complement(3503689..3503823) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7539334, 9371771, 12682299, 23002217, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7539334, 9371771, 12682299, 23002217, 25182490; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L34" /protein_id="NP_391986.1" /db_xref="EnsemblGenomes-Gn:BSU41060" /db_xref="EnsemblGenomes-Tr:CAB16143" /db_xref="GOA:P05647" /db_xref="InterPro:IPR000271" /db_xref="InterPro:IPR020939" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10064" /db_xref="UniProtKB/Swiss-Prot:P05647" /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA *" /label="rpmH CDS" gene complement(3503689..3503823) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /label="rpmH gene" promotor_no_box 3503847..3503947 /Source="Nicolas_upshift_promotors" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(3503859..3503878) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3503869) /Source="Nicolas_upshifts" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3503871..3503939) /Source="Nicolas_S_feature" /locus_tag="new_4215437_4215505_c" /HighExp="Oxctl, G180, Paraq, H2O2, LBGstat, GM 120, MG-0.2, HPh, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1582" promotor_-35 complement(3503894..3503901) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3503907..>3504040 /Source="Nicolas_S_feature" /locus_tag="new_4215473_4215670" /HighExp="T0.30H, C30, T1.0H, T1.30H, T0.0H, T-0.40H, S2, T-1.10H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.048" /TUlongSig="NA" /TUlongPSig="NA" /label="S1583" upshifts 3503907 /Source="Nicolas_upshifts" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3503925..3503944) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3503939) /Source="Nicolas_upshifts" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3503960..3503964) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3504041..3504188 /locus_tag="new_1_148" /created_by="stephanmichalik" /label="S1" S_feature complement(3504064..3504337) /locus_tag="new_24_297_c" /created_by="stephanmichalik" /label="S2" S_feature 3504190..3504449 /locus_tag="new_150_409" /created_by="stephanmichalik" /label="S3" ORIGIN 1 atggaaaata tattagacct gtggaaccaa gcccttgctc aaatcgaaaa aaagttgagc 61 aaaccgagtt ttgagacttg gatgaagtca accaaagccc actcactgca aggcgataca 121 ttaacaatca cggctcccaa tgaatttgcc agagactggc tggagtccag atacttgcat 181 ctgattgcag atactatata tgaattaacc ggggaagaat tgagcattaa gtttgtcatt 241 cctcaaaatc aagatgttga ggactttatg ccgaaaccgc aagtcaaaaa agcggtcaaa 301 gaagatacat ctgattttcc tcaaaatatg ctcaatccaa aatatacttt tgatactttt 361 gtcatcggat ctggaaaccg atttgcacat gctgcttccc tcgcagtagc ggaagcgccc 421 gcgaaagctt acaacccttt atttatctat gggggcgtcg gcttagggaa aacacactta 481 atgcatgcga tcggccatta tgtaatagat cataatcctt ctgccaaagt ggtttatctg 541 tcttctgaga aatttacaaa cgaattcatc aactctatcc gagataataa agccgtcgac 601 ttccgcaatc gctatcgaaa tgttgatgtg cttttgatag atgatattca atttttagcg 661 gggaaagaac aaacccagga agaatttttc catacattta acacattaca cgaagaaagc 721 aaacaaatcg tcatttcaag tgaccggccg ccaaaggaaa ttccgacact tgaagacaga 781 ttgcgctcac gttttgaatg gggacttatt acagatatca caccgcctga tctagaaacg 841 agaattgcaa ttttaagaaa aaaggccaaa gcagagggcc tcgatattcc gaacgaggtt 901 atgctttaca tcgcgaatca aatcgacagc aatattcggg aactcgaagg agcattaatc 961 agagttgtcg cttattcatc tttaattaat aaagatatta atgctgatct ggccgctgag 1021 gcgttgaaag atattattcc ttcctcaaaa ccgaaagtca ttacgataaa agaaattcag 1081 agggtagtag gccagcaatt taatattaaa ctcgaggatt tcaaagcaaa aaaacggaca 1141 aagtcagtag cttttccgcg tcaaatcgcc atgtacttat caagggaaat gactgattcc 1201 tctcttccta aaatcggtga agagtttgga ggacgtgatc atacgaccgt tattcatgcg 1261 catgaaaaaa tttcaaaact gctggcagat gatgaacagc ttcagcagca tgtaaaagaa 1321 attaaagaac agcttaaata gcaggaccgg ggatcaatcg gggaaagtgt gaataacttt 1381 tcggaagtca tacacagtct gtccacatgt ggataggctg tgtttcctgt ctttttcaca 1441 acttatccac aaatccacag gccctactat tacttctact attttttata aatatatata 1501 ttaatacatt atccgttagg aggataaaaa tgaaattcac gattcaaaaa gatcgtcttg 1561 ttgaaagtgt ccaagatgta ttaaaagcag tttcatccag aaccacgatt cccattctga 1621 ctggtattaa aattgttgca tcagatgatg gagtatcctt tacagggagt gactcagata 1681 tttctattga atccttcatt ccaaaagaag aaggagataa agaaatcgtc actattgaac 1741 agcccggaag catcgtttta caggctcgct tttttagtga aattgtaaaa aaattgccga 1801 tggcaactgt agaaattgaa gtccaaaatc agtatttgac gattatccgt tctggtaaag 1861 ctgaatttaa tctaaacgga ctggatgctg atgaatatcc gcacttgccg cagattgaag 1921 agcatcatgc gattcagatc ccaactgatt tgttaaaaaa tctaatcaga caaacagtat 1981 ttgcagtgtc cacctcagaa acacgcccta tcttgacagg tgtaaactgg aaagtggagc 2041 aaagtgaatt attatgcact gcaacggata gccaccgtct tgcattaaga aaggcgaaac 2101 ttgatattcc agaagacaga tcttataacg tcgtgattcc gggaaaaagt ttaactgaac 2161 tcagcaagat tttagatgac aaccaggaac ttgtagatat cgtcatcaca gaaacccaag 2221 ttctgtttaa agcgaaaaac gtcttgttct tctcacggct tctggacggg aattatccag 2281 acacaaccag cctgattccg caagacagca aaacagaaat cattgtgaac acaaaagaat 2341 tccttcaggc cattgatcgt gcatctcttt tagctagaga gggacgcaac aacgttgtaa 2401 aactgtccgc aaaaccggct gaatccattg aaatttcttc caattcgcca gaaatcggta 2461 aagttgtgga agcaattgtt gcggatcaaa ttgaaggtga ggaattaaat atctctttta 2521 gtccaaaata tatgctggat gcactaaagg tgcttgaagg agcagaaata cgcgtaagct 2581 ttacaggcgc aatgagacct ttcttaattc gcacgccgaa tgatgaaacg attgtacagc 2641 ttatccttcc tgtcagaacc tattaatccg atacactgct gccgacccgt cggcagcttt 2701 tctattcggt atctgctccg acaagttttc cctttcccta attcgttttt ttttagtaca 2761 attagatatt agtgatattt gaaagaggtc gatataatgg caaatccgat ttcaattgat 2821 acagagatga ttacactcgg acaattctta aaattagccg atgtgattca gtctggcggt 2881 atggcgaagt ggtttttaag cgagcatgaa gtgcttgtga acgatgagcc ggacaaccgc 2941 cggggcagaa agctgtatgt tggagatgtg gtagagattg aaggatttgg ttcatttcaa 3001 gtcgtcaatt aaagcgggtg acactgattg tatatccaga acttagaact gacatcttac 3061 cgcaactacg accatgctga acttcaattt gaaaataaag taaatgtgat catcggagaa 3121 aacgcccagg ggaagacaaa cctcatggag gcgatctatg tcttgtccat ggcgaaatcg 3181 caccggacat caaatgacaa agaacttata cggtgggaca aagactatgc taaaatagag 3241 ggaagagtga tgaagcaaaa cggggcgatc ccgatgcagc tcgtcatctc caaaaagggt 3301 aaaaagggca aggtcaatca tattgaacag caaaagctca gccagtatgt cggggccctc 3361 aacaccatta tgttcgcgcc ggaagattta aatcttgtaa agggaagccc tcaagtgaga 3421 aggcggtttc ttgacatgga aatcggacag gtttctcccg tctaccttca tgatctttct 3481 ctttaccaga aaatcctttc ccagcggaat cattttttga aacagctgca aacaagaaaa 3541 caaactgacc ggacgatgct cgatgttctg accgatcagc ttgtagaagt tgcagcaaaa 3601 gtcgtcgtaa aacgcctgca gtttacagca cagctcgaga aatgggcgca gcccatccat 3661 gcaggcatct caagagggct tgaagaactg accctgaaat accatacagc tcttgatgta 3721 tcagatcccc tagatttgtc gaaaatagga gatagctatc aagaagcgtt ttctaaatta 3781 agagaaaaag aaattgagcg tggtgtgacg ctgtcagggc ctcatcgcga tgatgttctt 3841 ttctatgtga acggacgcga tgtgcagacg tatggttctc aaggacagca gcgaacgacg 3901 gcgttgtccc ttaagctggc ggagattgac ctgatccatg aagaaatcgg agaatatccc 3961 attttactat tggatgatgt actgagtgaa ctggatgatt atcgccagtc acacttgctt 4021 catacgatcc aaggccgtgt acaaacgttt gtcacaacga caagcgttga tggcattgat 4081 cacgaaacct tacgtcaagc aggaatgttc cgtgtgcaaa atggtgcgtt agtgaagtga 4141 agaaatgagg tgagcaattg tatattcatt taggtgatga ctttgtggtt tcaacacgag 4201 atattgtcgg catttttgac tttaaagcca acatgtcgcc tattgttgaa gaatttctga 4261 aaaaacagaa acacaaggtg gtgccttccg taaacggcac gcccaaatct atcgtagtca 4321 cggttcagaa tatatattac tctcccttat cttccagcac attaaaaaaa cgtgcgcaat 4381 ttatgtttga aatagattct tagaaatttt ttatcacgaa tatatcgttt agaaaagtgt 4441 aggtgaatga cgtggctatg gaacagcagc aaaacagtta tgatgaaaat cagatacagg 4501 tactagaagg attggaagct gttcgtaaaa gaccggggat gtatatcggt tcgacaaaca 4561 gcaaaggcct tcaccacttg gtatgggaaa ttgtcgacaa tagtattgac gaagccctcg 4621 ccggttattg tacggatatc aatatccaaa tcgaaaaaga caacagtatc acggttgtag 4681 ataatggccg cggtattcca gtcggtattc atgaaaaaat gggccgtcct gcggtagaag 4741 tcattatgac ggtgcttcat gccggaggaa aatttgacgg aagcggctat aaagtatccg 4801 gaggattaca cggtgtaggt gcgtcggtcg taaacgcact atcaacagag cttgatgtga 4861 cggttcaccg tgacggtaaa attcaccgcc aaacctataa acgcggagtt ccggttacag 4921 accttgaaat cattggcgaa acggatcata caggaacgac gacacatttt gtcccggacc 4981 ctgaaatttt ctcagaaaca accgagtatg attacgatct gcttgccaac cgcgtgcgtg 5041 aattagcctt tttaacaaag ggcgtaaaca tcacgattga agataaacgt gaaggacaag 5101 agcgcaaaaa tgaataccat tacgaaggcg gaattaaaag ttatgtagag tatttaaacc 5161 gctctaaaga ggttgtccat gaagagccga tttacattga aggcgaaaag gacggcatta 5221 cggttgaagt ggctttgcaa tacaatgaca gctacacaag caacatttac tcgtttacaa 5281 acaacattaa cacgtacgaa ggcggtaccc atgaagctgg cttcaaaacg ggcctgactc 5341 gtgttatcaa cgattacgcc agaaaaaaag ggcttattaa agaaaatgat ccaaacctaa 5401 gcggagatga cgtaagggaa gggctgacag cgattatttc aatcaaacac cctgatccgc 5461 agtttgaggg ccaaacaaaa acaaagctgg gcaactcaga agcacggacg atcaccgata 5521 cgttattttc tacggcgatg gaaacattta tgctggaaaa tccagatgca gccaaaaaaa 5581 ttgtcgataa aggtttaatg gcggcaagag caagaatggc tgcgaaaaaa gcgcgtgaac 5641 taacacgccg taagagtgct ttggaaattt caaacctgcc cggtaagtta gcggactgct 5701 cttcaaaaga tccgagcatc tccgagttat atatcgtaga gggtgactct gccggaggat 5761 ctgctaaaca aggacgcgac agacatttcc aagccatttt gccgcttaga ggtaaaatcc 5821 taaacgttga aaaggccaga ctggataaaa tcctttctaa caacgaagtt cgctctatga 5881 tcacagcgct cggcacaggt atcggagaag acttcaacct tgagaaagcc cgttaccaca 5941 aagttgtcat tatgacagat gccgatgttg acggcgcgca catcagaaca ctgctgttaa 6001 cgttctttta cagatatatg cgccaaatta tcgaaaatgg ctacgtgtac attgcgcagc 6061 cgccgctcta caaggttcaa caggggaaac gcgttgaata tgcatacaat gacaaggagc 6121 ttgaagagct gttaaaaact cttcctcaaa cgcctaagcc tggactgcag cgttacaaag 6181 gtcttggtga aatgaatgcc acccagctat gggagacaac catggatcct agctccagaa 6241 cacttcttca ggtaactctt gaagatgcaa tggatgcgga tgagactttt gaaatgctta 6301 tgggcgacaa ggtagaaccg cgccgaaact tcatagaagc gaatgcgaga tacgttaaaa 6361 atcttgacat ctaatcataa aaagccttat ttccaataag aaataaggct tttttctgaa 6421 caagatcaga tgcagcgatg cctgcaatac ctatatattc tagcaattta atgtgtataa 6481 tcataagttt attgatataa tggagaatag tgaaatcgta ttgaaggtca taatggacaa 6541 tctactccca catatttcat gtgatacttc agggaggttt tttaatgagt gaacaaaaca 6601 caccacaagt tcgtgaaata aatatcagtc aggaaatgcg tacgtccttc ttggattatg 6661 caatgagcgt tatcgtgtcc cgtgctcttc cggatgttcg tgacggttta aaaccggttc 6721 atagacggat tttgtatgca atgaatgatt taggcatgac aagtgacaag ccttataaaa 6781 aatccgcgcg tatcgttgga gaagttatcg ggaaatacca cccgcacggt gattcagcgg 6841 tatatgaatc catggtcaga atggctcagg atttcaacta ccgttatatg ctcgttgacg 6901 gtcacggaaa cttcggttct gttgacggag actcagcggc ggccatgcgt tatacagaag 6961 cacgaatgtc taaaatctca atggagattc ttcgcgacat cacaaaagac acaatcgatt 7021 accaggataa ctatgacggg tcagaaagag aacctgtcgt tatgccttca aggttcccga 7081 atctgctcgt gaacggtgct gccggcattg cggtaggtat ggcaacaaac attcctccgc 7141 accagctggg agaaatcatt gacggtgtac ttgctgttag tgagaatccg gacattacaa 7201 ttccagagct tatggaagtc attccagggc ctgatttccc gaccgcgggt caaatcttgg 7261 gacgcagcgg tatccggaaa gcatacgaat caggccgagg ctctatcacg atccgggcaa 7321 aagctgagat cgaacaaaca tcttcgggta aagaaagaat tatcgttaca gagttacctt 7381 accaagtaaa taaggcgaaa ttaattgaga aaattgctga tctcgtaagg gacaaaaaga 7441 tagagggtat cacagatctg cgtgatgagt cagatcgtac aggtatgaga attgtcattg 7501 aaatcagacg cgatgccaat gcgaatgtta tcttaaacaa tctgtacaaa caaactgctc 7561 tacaaacatc ttttggcatc aacctgcttg cgcttgttga tggccagccg aaagttttaa 7621 ctcttaagca atgcctggag cattaccttg accatcaaaa agttgtcatt agacgccgta 7681 ctgcttatga attgcgtaaa gcagaagcga gagctcatat cttggaagga ttgagagttg 7741 cactggatca tctcgatgca gttatctccc ttatccgtaa ttctcaaacg gctgaaattg 7801 cgagaacagg tttaattgaa caattctcac tgacagagaa gcaagcacaa gcgatccttg 7861 acatgaggct ccagcgttta acgggactgg aacgtgaaaa gatcgaagaa gaataccagt 7921 ctcttgttaa attaattgca gagctaaaag acatcttggc aaatgaatat aaagtgcttg 7981 agatcattcg tgaagaactc acggaaatca aagagcgttt taacgatgaa agacgtactg 8041 agatcgtcac ttctggactg gagacaattg aagatgaaga tctcatcgag agagaaaata 8101 tcgtagttac tctgacgcac aacggatacg tcaaacgtct tcctgcatca acttaccgca 8161 gtcaaaaacg gggcggaaaa ggtgtacaag gtatgggaac aaacgaagat gatttcgttg 8221 aacatttgat ctctacgtca actcatgaca cgattctctt cttctcgaac aaggggaaag 8281 tgtatcgtgc aaaagggtat gaaatccctg aatacggcag aacggcaaaa ggaatcccga 8341 ttattaacct gctggaggta gaaaagggtg agtggatcaa cgcgattatt ccagtcacgg 8401 aattcaatgc ggagctttac ctcttcttca ctacaaagca tggggtttca aaacgaacat 8461 cgctatctca attcgctaat atccgcaaca atggtctaat tgctctgagt cttcgtgaag 8521 atgatgaact gatgggtgta cgtctgactg acggcacaaa acaaatcatc attggaacga 8581 aaaacggttt actgattcgt ttccctgaaa cagatgtccg agagatggga agaactgcgg 8641 cgggcgtaaa aggcatcacc ctgacggatg acgacgttgt tgtcggcatg gagattttag 8701 aggaagaatc acacgtcctt atcgtaactg aaaaagggta cggaaaacga actcctgctg 8761 aagagtacag aacccaaagc cggggcggaa aaggactcaa aacagcgaaa atcaccgaga 8821 acaacggcca actagtagca gtgaaagcta ctaaaggtga agaggatcta atgattatta 8881 cagctagcgg cgtactcatc agaatggaca tcaatgatat ctccatcacc ggacgtgtca 8941 ctcaaggtgt gcgtctcatc agaatggcag aagaagagca tgttgctaca gtagctttag 9001 ttgagaaaaa cgaagaagat gagaatgaag aagaacaaga agaagtgtga aaaaaagcgc 9061 agctgaaata gctgcgcttt tttgtgtcat aaccctttac agtcataaaa attatggtat 9121 aatcatttct gttgtctttt taaagacaca agcatgacca ttatgactag taaaaacttt 9181 ttcaaaaaag tattgaccta gttaactaaa aatgttacta ttaagtagtc gctttgagag 9241 aagcacacaa agttctttga aaactaaaca agacaaaacg tacctgttaa ttcattttta 9301 taaatcgcac agcgatgtgc gtagtcagtc aaactagggc ctgcacgacg caggtcacac 9361 aggtgtcgcc gcaggatgcg gtgaacttaa cctgtgatcc atttatcgga gagtttgatc 9421 ctggctcagg acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg gacagatggg 9481 agcttgctcc ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa 9541 gactgggata actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt 9601 caaacataaa aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt 9661 tggtgaggta acggctcacc aaggcgacga tgcgtagccg acctgagagg gtgatcggcc 9721 acactgggac tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc 9781 aatggacgaa agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa 9841 gctctgttgt tagggaagaa caagtgccgt tcgaataggg cggtaccttg acggtaccta 9901 accagaaagc cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt 9961 tgtccggaat tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc 10021 ccccggctca accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag 10081 tggaattcca cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg 10141 cgactctctg gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag 10201 ataccctggt agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct 10261 tagtgctgca gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac 10321 tcaaaggaat tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac 10381 gcgaagaacc ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt 10441 cgggggcaga gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt 10501 taagtcccgc aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta 10561 aggtgactgc cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct 10621 tatgacctgg gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg 10681 ttaagccaat cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg 10741 aagctggaat cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt 10801 gtacacaccg cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt 10861 ttaggagcca gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc 10921 gtatcggaag gtgcggctgg atcacctcct ttctaaggat attttacgga atataagacc 10981 ttgggtctta taaacagaac gttccctgtc ttgtttagtt ttgaaggaac tttgttcctt 11041 gaataagtta agatgggcct gtagctcagc tggttagagc gcacgcctga taagcgtgag 11101 gtcggtggtt cgagtccact caggcccacc atcttatata acggggcctt agctcagctg 11161 ggagagcgcc tgctttgcac gcaggaggtc agcggttcga tcccgctagg ctccaccaac 11221 gtgttctttg aaaactagat aacagtagac atcacattca attagtaaca caagatatca 11281 catagtgatt ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta 11341 ggagccgatg aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg 11401 atccggagat ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga 11461 attcatagga tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag 11521 agaaagcaaa tgcgattccc tgagtagcgg cgagcgaaac gggatcagcc caaaccaaga 11581 ggcttgcctc ttggggttgt aggacactct gtacggagtt acaaaggaac gaggtagatg 11641 aagaggtctg gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc 11701 tcctgagtgg atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc 11761 atctcccaag gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg 11821 tgaaaagcac cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc 11881 agagcccgtt aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatctc 11941 gtgcaaggtt aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg 12001 agtacgtggt cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt 12061 aacactgaat ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta 12121 ggggtgaaat gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct 12181 agcctcaagg taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt 12241 taccgaattc agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt 12301 gataagatcc gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata 12361 cgttaagtgg aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc 12421 caccatttaa agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc 12481 ggggctaaac gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc 12541 taagggctgt gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt 12601 atgagtagcg aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa 12661 ggctcgtccg ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga 12721 caacaggttg atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag 12781 gatagggtaa gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa 12841 atccgtttcc cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga 12901 ttccacactg ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca 12961 caggtaggcg aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca 13021 aaatgacccc gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc 13081 gcagtgaata ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg 13141 cgaagtatag gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa 13201 gcgaaggtgc gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta 13261 gcgaaattcc ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg 13321 tctcaacgag agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag 13381 gacggaaaga ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta 13441 caggataggt aggagccttg gaaaccggag cgccagcttc ggtggaggca tcggtgggat 13501 actaccctgg ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc 13561 aggtgggcag tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt 13621 ccctcagaat ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga 13681 gacctacaag tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa 13741 gggccatcgc tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag 13801 tccacatcga cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag 13861 tcggtcccaa gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg 13921 tcgtgagaca gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct 13981 tagtacgaga ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat 14041 cgctgggtag ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc 14101 tcaagatgag atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat 14161 aggtctgagg tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgaggact 14221 taaccatatt tttgaatgat gtcacacctg ttatctagtt ttgagagaac actctcaatt 14281 tgtttggtgg cgatagcgaa gaggtcacac ccgttcccat accgaacacg gaagttaagc 14341 tcttcagcgc cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcaa 14401 gcttaaaccc agctcaatga gctgggtttt ttgtttgtta aaaatgaaga agaaactgtg 14461 aagcgtattt agggaatttc ttttctgata ctaataaaaa ctgctgaatt aacacgtagt 14521 catcacttat atgctgtgtt aataactcat accaccattc tgtttcatac cttgcaatca 14581 tcccaacgtt gtacaaaatc aaataatgaa ttgtcatttc gggaagcctc agaaattgct 14641 ccctttgaga agggatataa tattggttct tttccatgtc aaacaataag ctggtcgatg 14701 tccatggctc cttgtcttgt ggtgaaattt cgaacagcag cccgtgttca tttttttttg 14761 taaaagacca ttgataatga tgggacatgt attcagcaaa ccttgaatca gacattttgt 14821 aattgattac tacttcctcc ggtacaaaaa tttcgttctt atccttctca acttttgtca 14881 taaatcgttc tttctgctga aagtagaaaa tatcgctaag ttctggaatg gccattaata 14941 attttttcat ggtataccgt tcatctacta tatccgattg tccgaataaa tgtttcataa 15001 aatgtacgca taggccattc cgttgtattt tcacttcatc gtcgctaaaa caataatttt 15061 gtttctttcg ttttcttgtt gttacgccat gtgccagtac tgatgtatgg cttggataat 15121 gaggatcacg tgtaattaag catgctttga taagctgtgc cattccataa aataaaagaa 15181 tcggtttgat ttctaaggga gaatatgcgg cttgtttata aaacgattcg gcatgcttta 15241 agaaataaat aaaccgttca ctgtttttaa aagagttttt tttcgcatcg ttaataccgt 15301 ttaagatata aaccttttct agaaatttct gggttgattc aacggagtaa aatagcgcta 15361 agtctttcca ctcatgatat gtcatgtata tttcttaatc ctttccgtta tctaaatatt 15421 tcaactcttt cccgcttcct tgacatgctc ttggctagtt gataatctac atataatatt 15481 ttgccgaaaa gagggggatt tactaatgtg ggaaagtaaa ttttcaaaag aaggcttaac 15541 gttcgacgat gtgctgcttg taccagcaaa gtctgaggta cttccgcgtg atgtggattt 15601 atctgtagaa cttacaaaaa cgttaaagct aaatattcct gtcatcagcg caggtatgga 15661 cactgtaaca gaatcagcaa tggcaattgc aatggcaaga cagggcggct tgggcatcat 15721 tcacaaaaat atgtccattg aacagcaggc tgaacaagtt gataaagtaa agcgttctga 15781 gcgcggcgtt atcacaaatc ccttcttttt aactcctgat caccaagtat ttgatgcgga 15841 gcatttgatg gggaaataca gaatttccgg tgttccgatt gtaaataacg aagaagacca 15901 gaagcttgtt ggaattatta caaaccgtga ccttcgtttt atttctgact actcaatgaa 15961 aatcagcgac gtcatgacga aagaagagct agttactgca tctgtaggaa ctactctgga 16021 tgaagctgaa aagattttgc agaaacataa aattgaaaag cttcctctcg tagatgacca 16081 gaataaatta aaaggtctta tcacaattaa agacattgaa aaagtcattg agttcccgaa 16141 ctcatctaaa gacattcacg gccgcctgat cgttggcgcg gcagttggtg taactggcga 16201 tacaatgact cgcgtcaaaa agcttgttga agccaatgtt gatgtgattg ttatcgatac 16261 agctcacgga cactctcaag gcgttttaaa cacagtcaca aaaatccgtg aaacgtatcc 16321 cgaattaaac attattgctg gaaacgtggc aacagctgaa gcgacaagag cgcttatcga 16381 agctggagca gacgttgtca aagttggaat agggcctggt tcaatttgta ctacacgtgt 16441 tgtagccggc gtgggtgttc cgcaaattac agcaatttat gattgtgcga ctgaagcaag 16501 aaaacacggc aaaacaatca tcgccgacgg tgggattaaa ttctctggcg atatcactaa 16561 agcattggca gccggcggac atgctgttat gctcggaagc ttgcttgcag gcacatcaga 16621 aagccctggt gaaactgaaa tctaccaagg cagaagattt aaggtatacc gcggcatggg 16681 atcagttgct gcaatggaaa aaggaagtaa agaccgttac ttccaagaag aaaacaaaaa 16741 atttgttcct gaaggaattg aaggacgcac accttacaaa gggccagttg aagaaaccgt 16801 ttatcagcta gtcggaggcc ttcgttctgg tatggggtat tgcgggtcca aagatctgcg 16861 tgcgctaaga gaagaagctc agttcattcg catgactggc gcaggacttc gcgaaagcca 16921 tccgcatgac gtacagatta caaaagaatc acctaactat acaatttcat aataaattgt 16981 tacaaattaa aaacatttga cagggtctct gactctgtct atttttttta tactgattat 17041 gataaaattt atactgttgt gcattgaaaa tgtccttaac ggcttaatta tagatgaaga 17101 aaatgaaata cggaggtcgt acgattgaac atcaagaaat gtaaacagct actgatgtca 17161 ttggttgtgt taactctagc tgtcacgtgt ctggctccaa tgtcaaaagc gaaagcagcc 17221 agcgatccaa ttgatatcaa tgcatctgct gctattatga tcgaagcttc ttcaggtaaa 17281 attctttaca gtaaaaatgc agataagaga ctgccaattg cgagtatgac aaaaatgatg 17341 acagagtatc tgttattgga agcaattgat caaggtaaag tgaaatggga ccaaacctat 17401 acgcctgatg actatgtgta tgaaatttcc caagataaca gcttatcaaa cgttcctctt 17461 cggaaagacg ggaaatacac agtaaaagaa ttatatcaag ctacagcaat ttattctgca 17521 aatgctgctg ctattgcgat tgcagaaatc gttgccggtt ctgaaactaa gtttgttgaa 17581 aaaatgaatg caaaagcaaa agaactaggc ttaacagatt acaaatttgt taacgcaaca 17641 ggtcttgaaa acaaagatct tcacgggcat cagcctgagg ggacaagcgt aaatgaagaa 17701 agtgaagttt ctgcaaagga tatggcggtt cttgcggatc acttgattac tgactaccct 17761 gagatactgg agacttccag tatcgccaaa acgaaattca gagaaggcac cgatgatgaa 17821 atggacatgc cgaactggaa ttttatgctg aaggggcttg tcagcgagta taaaaaagcg 17881 actgtagacg gactgaaaac aggttctact gactctgcgg gttcatgctt tacaggaaca 17941 gctgaacgca acggtatgcg tgtcatcact gttgttttaa acgcaaaggg caaccttcat 18001 acaggccgtt tcgatgaaac gaaaaaaatg tttgattatg ctttcgacaa tttctccatg 18061 aaagaaattt atgctgaagg cgatcaagta aaaggccata aaacaatttc agttgataag 18121 ggtaaagaga aagaagtagg cattgtgaca aacaaggcgt tctctcttcc tgtcaaaaat 18181 ggtgaagaaa agaattacaa agcgaaggtc acactgaata aagacaactt aactgctcct 18241 gtgaaaaaag gaaccaaggt tgggaagctg actgcggaat acacaggtga tgaaaaggat 18301 tacggattcc ttaacagcga tctggctggc gtagaccttg ttacaaaaga aaatgtagaa 18361 aaagcaaact ggtttgtttt gacaatgcgc agtatcggcg gattttttgc cggaatttgg 18421 ggaagcattg ttgatacggt aaccggctgg ttttaatcaa ttgaaagagc tctgatggat 18481 gttagggctc tttcgcgtaa tatactgaaa aaacccaatt tttaataaaa aatgattttc 18541 aaagcgctaa aaaccgaata aaatagtata tatgcatatg aattattgga tttctaggat 18601 acaataagga ttagaaatca tataactata ccttgattag ggggaccaag aaatggctca 18661 aacaggtact gaacgtgtaa aacgcggaat ggcagaaatg caaaaaggcg gcgtcatcat 18721 ggacgtcatc aatgcggaac aagcgaaaat cgctgaagaa gctggagctg tcgctgtaat 18781 ggcgctagaa cgtgtgccag cagatattcg cgcggctgga ggagttgccc gtatggctga 18841 ccctacaatc gtggaagaag taatgaatgc agtatctatc ccggtaatgg caaaagcgcg 18901 tatcggacat attgttgaag cgcgtgtgct tgaagctatg ggtgttgact atattgatga 18961 aagtgaagtt ctgacgccgg ctgacgaaga atttcattta aataaaaatg aatacacagt 19021 tccttttgtc tgtggctgcc gtgatcttgg tgaagcaaca cgccgtattg cggaaggtgc 19081 ttctatgctt cgcacaaaag gtgagcctgg aacaggtaat attgttgagg ctgttcgcca 19141 tatgcgtaaa gttaacgctc aagtgcgcaa agtagttgcg atgagtgagg atgagctaat 19201 gacagaagcg aaaaacctag gtgctcctta cgagcttctt cttcaaatta aaaaagacgg 19261 caagcttcct gtcgttaact ttgccgctgg cggcgtagca actccagctg atgctgctct 19321 catgatgcag cttggtgctg acggagtatt tgttggttct ggtattttta aatcagacaa 19381 ccctgctaaa tttgcgaaag caattgtgga agcaacaact cactttactg attacaaatt 19441 aatcgctgag ttgtcaaaag agcttggtac tgcaatgaaa gggattgaaa tctcaaactt 19501 acttccagaa cagcgtatgc aagaacgcgg ctggtaagaa cataggagcg ctgctgacat 19561 gttaacaata ggtgtactag gacttcaagg agcagttaga gagcacatcc atgcgattga 19621 agcatgcggc gcggctggtc ttgtcgtaaa acgtccggag cagctgaacg aagttgacgg 19681 gttgattttg ccgggcggtg agagcacgac gatgcgccgt ttgatcgata cgtatcaatt 19741 catggagccg cttcgtgaat tcgctgctca gggcaaaccg atgtttggaa catgtgccgg 19801 attaattata ttagcaaaag aaattgccgg ttcagataat cctcatttag gtcttctgaa 19861 tgtggttgta gaacgtaatt catttggccg gcaggttgac agctttgaag ctgatttaac 19921 aattaaaggc ttggacgagc cttttactgg ggtattcatc cgtgctccgc atattttaga 19981 agctggtgaa aatgttgaag ttctatcgga gcataatggt cgtattgtag ccgcgaaaca 20041 ggggcaattc cttggctgct cattccatcc ggagctgaca gaagatcacc gagtgacgca 20101 gctgtttgtt gaaatggttg aggaatataa gcaaaaggca cttgtataaa acagttgaaa 20161 gctgtggaaa cttatagtac attataagca caaataaaga tcgaaaagcg ttgataggaa 20221 ctagtaggga gcctctcttt ctaagagagc cgatggttgg tgcgaatcgg tgaaagatgc 20281 tgtctgaatc catccttgag cgaaatgctg aagcgagtag gcatttacgg gataaccgtt 20341 atgtttgaaa gtggaaaacg agtctttgat ttgttttcaa tcagggtggc aacgcgagag 20401 ctctcgtccc tttatgggga tgagggctct ttttattttc gataaatcaa taaaaaaagg 20461 agtgtttcgc atgcttgata cgaaaatgct gagagcaaat tttcaagaaa ttaaagcaaa 20521 gcttgtacac aaaggcgaag acttaactga ttttgataag tttgaggcgc tggatgatag 20581 acgaagagag cttatcggca aggttgaaga gttaaaagga aaacgaaatg aagtttctca 20641 gcaggttgct gtgctgaagc gtgagaaaaa agacgcggat cacattatta aagaaatgcg 20701 tgaagtcggc gaggaaatta aaaagctcga tgaagaatta cggacagtgg aagctgagct 20761 tgatacaatc ctgctctcaa tcccgaatat tccgcatgag tctgtacctg tcggtgaaac 20821 agaagacgac aacgtagaag tgcgtaaatg gggtgaaaag ccttcatttg cttatgagcc 20881 gaagccgcac tgggatattg cggatgagct gggtattctg gattttgaac gtgctgccaa 20941 agtaacagga agccgtttcg tgttctataa aggcttaggt gctcgtctgg agcgtgcgct 21001 ttataacttt atgcttgatc tgcatgtgga tgagtataac tacactgaag tgatcccgcc 21061 atatatggta aaccgcgcaa gcatgacggg aacggggcag cttcctaaat ttgaagagga 21121 tgcatttaaa atcagagaag aagattattt cttaattcca acggcggaag tgccgattac 21181 aaacatgcat cgcgatgaaa tcctttcagg tgacagcctg ccgatcaact atgcggcatt 21241 cagtgcttgc ttccgttctg aagctggttc agcaggacgt gacacacgcg gattaattcg 21301 tcagcaccaa tttaataaag ttgagcttgt aaagtttgtg aagcctgaag attcttatga 21361 agaattagag aaacttacaa accaagcaga acgggttctt cagctgcttg agcttccata 21421 ccgtgtcatg agcatgtgta cgggtgactt aggctttacg gctgcgaaaa aatacgatat 21481 cgaagtttgg attccaagcc aagacacata tcgagaaatc tcttcttgca gcaacttcga 21541 agcgttccag gcgagacgtg cgaatattcg tttcagacgt gaagcgaaag gcaagcctga 21601 gcatgtacac acactgaacg gctcaggact ggcggttgga agaacagttg ctgctatctt 21661 agaaaattat cagcaggaag acggaagcgt tgtgattccg aaagtgcttc gtccttatat 21721 ggggaataga gaagtaatga aaccgtaaat tatggaaagg cgtgcctgac aaggtgcgcc 21781 tttttgctta tgtaaacacg gcattttcat aaaaacaaaa aaagttttta aaaatgcttg 21841 accacacgag aacatacgtg atatagttag tcttgtcgat acggaggaat acccaagtcc 21901 ggctgaaggg atcggtcttg aaaaccgaca ggggtgtcaa agcccgcggg ggttcgaatc 21961 cctcttcctc cgccatattg attttaattc taatgaaaca caagcatata ttggagattg 22021 ttttgtccgt tgcattcggt gcggcggatt ttttatttta aagaaaaagt gaatctcgac 22081 tgagattcac tttttttgat tatcatgaat aactgaagca atttgatcta caatattttc 22141 aatcgagttt tcgtcgttca gaagatcata atcttcaatg cgaagtttta aaacagggca 22201 ggcattaaaa ccgcttatcc agttctcgta gcgtgtatgc atttcttccc aataagaccg 22261 gcttgtctga agctccatct cacggccgcg ttgttcaatc cggtttaaaa tgttctccag 22321 atctccttct aaatagatca acacatctgg atgtgggaaa tacggtgtca ttaccattgc 22381 ttcgaaaagg cttgtgtaag tcttataatc aacctttgac attgtccctt tatcagcatg 22441 catttttgcg aaaattcctg tatcttcata aatcgaacga tcctgtacaa aacctccgcc 22501 ggcttcaaaa attgttttct gttctttgaa gcgttcagct aagaagtaaa tttgaaggtg 22561 aaagctccaa cgttcaaaat catgatagaa cttttccaaa tatggattat gatcgacttc 22621 ctccaacgat gttttaaatc caagccgttt agctaaagtt tttgttaaag tcgattttcc 22681 gacacctact gttcctgcta ctgtaataat tgaattctta gggatatgat gttccttcat 22741 acgataagct cctttacatg ggcggcaatg cgttcaaagt cgctcttatt caaaacgaaa 22801 tcctttgaat caccatctac ggttaacact gtaagttcag ggtctgcttc ctgcagctgc 22861 ttgatggcga cttcataatc tgaaatcagc tgctccaaat agctagtttc aatttttttc 22921 tcaaaggggc gcccgcgttt ttcaatgcgg tgtagcaatg taggcagact ggcctttatg 22981 taaatgatga aattcggctt tggcagatca tccgttagca ggtgatatat ctttttgtat 23041 ttttccagct gatgtggaga caaggttcgt tccgcaaaaa tcacattttt ataaatatga 23101 taatcagcta ttacaggctg tccctttttt aaaaagtgat cactggtgtc ttcaagctgt 23161 ttgtatctgt gacaaagaaa aaacatctcg agctggaagc tccattcctt tatattgtca 23221 taaaacttat caaggtacgg gttatcctct acaatctcat tgatcatagg gaatccgaat 23281 ttttgtgaga gcatcgttgc gagagttgtt tttcctgccc cgataggacc ttctattgca 23341 ataaaagggg ctgtattcat cggaatcctc cttatatctg aaaaacgtgc gtcagttacc 23401 gaccttcata ttgtatcaca acccttgggt gcccccatga aaaaaagacg tttccaaatt 23461 atcgaaacgt ctttttgaca acattaaatt gatcagacag cagcagccag ttttgtggaa 23521 aggaaagacc cagcttccaa tagctgatgc ctcttaaatt cagctcttta atcagattga 23581 attttgcttg aatcgagcgg gcatcctcga accatacctc gtgccttctg ttttctgcat 23641 cagtatagcg gaagaaagga gcttgagcgg tttggtcata ctgaatggaa gcattgttct 23701 gatcagctat gacaatggct tgctgagggc ttactgctct tgctggagtt ccccctgctg 23761 tatatggcag cgtccagtca tatccatata aattctggcc catgacaatt ttgttcgcag 23821 gcatttcagt caaagcatat tctatgacat cacggacagg tccaattgga gaaaccgctt 23881 gaggcggtcc gccgctatag ccccattcat atgtcatgag aacaacaaag tcgacaattt 23941 cgccatgtgc cctgtaatca tgagcttcat accacctgcc ctgctgtgtt gcacttgttt 24001 taggagcaag agccgtagaa atttctaagc cctctcgatg gaaaagatcc cttgcttcgc 24061 ggaggaattg attataggcc tctctatcct ggggccgcaa atattcaaag tcgaaatgaa 24121 tgtcacggaa gccatatctt ctggcattct cgactatttc atttagaagc cgtcttttta 24181 cagtttcgtc gttcaaaagg atccggccaa gttcatcgct gaatgcctgg ttttctaggt 24241 tcgttataat catcatcaat gttgtatttt gactttctgt aatgctcctt aaattcgtta 24301 aaggcggtgc gactaaggtt ccgttccgct gtgcctggaa gctgaatgcg ccaaggtaag 24361 ttaagtaggg cgacgcttct ctggccgcct gctggagatt ttcgctgact tgatttcctc 24421 ggggctccaa ataagcattt gattcgatgt ctcgtttagg agctggaggg atgtataaac 24481 ggaaaccaat ctgaagcacg gtatttaact ggatgcggtt aacccttgcg agctcggctg 24541 ctgttgtatt gaactgccgg gcgatggatg tcagggtatc acctcgcttc acatcataga 24601 actggccagc tattggaatg acaatggttt gtccgacaac aaggctgtcg ggattcggta 24661 tttcattcgt ttcagtgatg tcatttgtgg ttgttctgta ttgtgaagcg atagcagaaa 24721 gagtgtcgcc ttgttttacc acataaattt gaatgaaaaa cgcctccttt catatcgcta 24781 tcaatgtatg aaagaaaagc gctgatcatg tttatttttc tataatttgt tcttccgtcg 24841 taatttctgc gaaaagaaca ttctccatca tggttaaggc gaattcgtta tcttcgtcac 24901 tgtttgacgc gatacagtcc ttaggaatcg tgatgctgta ttccctcata taagcgtcat 24961 tagcggtaaa cagcacgcat atattgccgg ctatacctgt tatgataata tgtctcacct 25021 gcaactcagt aagaagggtg tgaagtgctg tttcgtagaa agcggaatgt ttcggtttga 25081 ttaaaaaata atcagcatct accggagcta tctttgtgat gatatccttg cttctttcat 25141 ttgtgcattc ttgctgtatg tttttaatgt cagcttgcca aagtccataa tgatcattga 25201 tgtaaataat cggccattca ttttgtctcg cgtgctcctt taatgataaa atatgaggaa 25261 cgattttttc tgttttttta gcgagggttt cccccatatc gaattcaaaa ttattgatca 25321 tgtctacaat gagaagggct ttatctgctt tggacaatcg acagtctcct ttccgtttca 25381 gttatagtta atatgtagcc tttttaggca atgaaaaaac tttgaaaaga gagcttatcc 25441 ttatgacaca agatgaactt tatatgaaag aagcaattaa agaagcgaaa aaggctgaag 25501 agaaaggtga agtgccaata ggtgcggtgc ttgtcattaa tggtgaaatt atagcgcgtg 25561 cgcataattt aagagagact gaacagcgat ctattgccca tgcagaaatg cttgtaattg 25621 atgaagcgtg taaggcactc ggaacatggc ggctggaagg tgcgactctt tatgtgacgc 25681 ttgagccttg tccaatgtgt gctggtgcag tcgtactttc tcgagtggaa aaagtggttt 25741 ttggcgcatt tgatccgaaa ggcggctgtt caggcacgct aatgaacctt cttcaggagg 25801 aacgctttaa tcatcaggct gaagtggtga gcggtgtgct tgaggaagaa tgcggcggaa 25861 tgctcagtgc gtttttcaga gaactaagaa aaaagaagaa agccgccagg aaaaacttgt 25921 ctgaatagta cggttgcaat ttttagggga aacagatata cttaagtgtg catcgtaata 25981 gatgcaacat aaaatttgat atttattttg ccgtgctaag cggggaggta gcggtgccct 26041 gtacctgcaa tccgctctag cagggccgaa tcccttctcg aggttcgttt actttaaggc 26101 ctgccttaag taagtggtgt tgacgtttgg gtcctgcgca atgggaattc atgaaccatg 26161 tcaggtccgg aaggaagcag cattaagtga aacctctcat gtgccgcagg gttgcctggg 26221 ccgagctaac tgcttaagta acgcttaggg tagcgaatcg acagaaggtg cacggtaaat 26281 caatcatcaa attttcagac tcacctaata ttaggtgagt tttttgttat gtaaaaagag 26341 cttttggaat cgaaacaagg ttcatgtata atgggaatga tgaataacgg aggagggcaa 26401 acccgtgagt taccaagctt tatatcgagt attcaggcct cagcgctttg aagatgtggt 26461 cggacaagaa cacattacaa aaacgctgca aaatgccctt ttgcaaaaaa agttttctca 26521 cgcctatctg ttttccgggc ctagaggaac cggaaaaacc agtgcagcca aaatatttgc 26581 taaggctgtc aactgtgaac atgctcctgt tgatgagcca tgcaacgaat gtgcggcctg 26641 taaagggata acaaacgggt caatatccga tgtcatagaa attgacgccg cttctaataa 26701 cggtgttgat gagattcgtg acattcgcga taaagtgaag tttgccccat cggccgtcac 26761 atataaggta tatatcatag atgaggtgca tatgctttct atcggcgctt ttaatgcatt 26821 actaaaaaca ttagaagagc cgcctgagca ttgtattttc atattagcaa caactgaacc 26881 gcacaaaatt cctttaacca ttatctctag atgtcagcgt tttgacttta aacgaattac 26941 ctcccaagcg attgtaggcc gcatgaataa aattgttgat gctgaacagc tgcaagtgga 27001 ggaaggatcg ctggaaatca tcgcgagtgc tgcagacgga gggatgaggg atgccctgag 27061 ccttcttgat caggccatat cattcagcgg cgatatcctg aaagtcgaag atgcgctttt 27121 aattacgggt gctgtttctc aattatatat cgggaagctt gcaaaatccc tgcatgataa 27181 aaacgtttct gacgcactgg aaacattaaa tgaattgctt cagcaaggaa aagatccagc 27241 taagctgata gaagatatga ttttctattt cagggacatg ctgctgtaca aaacagcccc 27301 tggcttagag ggagtgcttg agaaagtaaa agtcgatgaa acgttccggg aactaagtga 27361 acaaattccg gctcaggccc tatatgaaat gattgatatt ctgaacaaga gccatcagga 27421 aatgaaatgg acaaatcatc cgcgtatctt tttcgaagtg gccgttgtga agatttgcca 27481 aacctcacat caatctgctg ctgatctccc ggaagtggat atgctgatga aaaaaatcca 27541 gcagctcgaa caggaagtag agcggctcaa aacaacgggc ataaaagcag ctgcggaaag 27601 cccgaaaaaa gaagcgccgc gtgtgccaaa gggcgggaaa tccaattaca aagcgccagt 27661 aggcagaatt catgagattt tgaaggaagc cacaagaccg gatcttgatc tgctcagaaa 27721 cagttggggc aagcttcttg ctcatctcaa acagcaaaac aaagtatcac atgccgcttt 27781 gctgaatgac agtgaacctg tggctgccgg atcggcggca tttgttctga aattcaaata 27841 tgaaattcat tgtaaaatgg tcgctgagga taacaacgga gtccggacta atcttgagca 27901 gattttagaa tcgatgctcg gaaaaagaat ggatttgatt ggcgttccag aagcacaatg 27961 gggtaaaata agagaagaat ttttagaaga tcatcagcag gaaaatgaag gatcaaatga 28021 accggctgaa gaagacccgc ttattgccga agcgaaaaag cttgttggag cggatttaat 28081 tgaaataaaa gactaacaaa atgaaagaga gtgaatgcta tgcgtggcgg aatgggtaat 28141 atgcaaaaaa tgatgaaaca aatgcaaaaa atgcaaaagg acatggcgaa ggctcaagaa 28201 gagcttgcag aaaaggttgt tgaaggaact gcaggcggcg gtatggtaac agtaaaagca 28261 aacggccaaa aagaaatcct ggatgttatc atcaaagaag aagtcgttga tcctgaagat 28321 attgatatgc ttcaagattt agtgcttgct gcaacgaatg aagctttgaa aaaagttgac 28381 gaaatcacaa acgaaacaat gggtcaattt acaaagggaa tgaacatgcc aggtttattc 28441 tagggggata aaagaacatg caatatcctg aaccaatatc aaagctgatt gacagcttta 28501 tgaaattgcc agggatcgga ccgaaaacag cggttcgtct ggcttttttt gttctaggta 28561 tgaaagaaga tgtagtatta gattttgcga aagcattagt aaatgcgaaa cgcaacctga 28621 catattgttc agtttgcggg catattacag atcaggaccc ttgctatata tgtgaagata 28681 cgcgcaggga taagtctgtt atctgtgttg tgcaagaccc taaagacgtt atcgctatgg 28741 agaaaatgaa ggaatacaac ggacagtatc acgttcttca cggcgctatt tctccaatgg 28801 acggcatcgg accggaggat attaaaatac cagaattgtt aaaacgatta caggatgatc 28861 aagtgacaga agtgatcctc gcgacaaacc ctaatataga aggggaagca acagcgatgt 28921 atatatcaag gctcctcaag ccgtctggta ttaagctctc ccgtattgcc cacggactgc 28981 ccgtcggcgg tgatttggaa tatgctgatg aggtcactct ttctaaagca cttgaaggaa 29041 gacgtgaatt gtaaggagga aaaagcgatc catgggtttt cttcgcaaga aaacattaag 29101 aagagagttt gatgaaaaac taaccgagca gctttttaag caaaaggaag agtggaacag 29161 gcaaaaaaag ctggttgaaa aaagcttaga accgtctgct gaagtgttat acgaactgaa 29221 agtagctgaa gcgaagtatt ttttttactt aagggaagcg aagcagcgaa atttaaaaat 29281 cagccggtgg aagtaagtgg tctaaactcc tggatcttct cataagcttg tactagaaca 29341 agcgaaggag atgagaagat tcatggagcc tatttttatt attgggatta ttttaggact 29401 ggttattctt ctttttttat caggttcagc agcgaagcct ttaaagtgga ttggcatcac 29461 agctgttaaa tttgtggcag gtgctttgct gctggtttgt gtaaatatgt ttggcggcag 29521 tcttggcatt catgtgccga ttaatctggt tacaacagct atcagcggaa ttttaggaat 29581 acccggaata gctgcgttag tcgtcattaa gcaatttatc atttaattga tattatgtat 29641 tgacttagac aactgaaggt gttattctaa tatacgtcgc tgatgacgaa cagctttttt 29701 gaaaagaaaa tgctaaaaag ttgttgacag tagcggcggt aaatgttatg ataataaagt 29761 cgcttaaacg agcggtaaac aaagttcttt gaaaactaaa caagacaaaa cgtacctgtt 29821 aattcatttt tataaatcgc acagcaatgt gcgtagtcag tcaaactact ttatcggaga 29881 gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa gtcgagcgga 29941 cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg tgggtaacct 30001 gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt tgtttgaacc 30061 gcatggttca aacataaaag gtggcttcgg ctaccactta cagatggacc cgcggcgcat 30121 tagctagttg gtgaggtaac ggctcaccaa ggcgacgatg cgtagccgac ctgagagggt 30181 gatcggccac actgggactg agacacggcc cagactccta cgggaggcag cagtagggaa 30241 tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga aggttttcgg 30301 atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg gtaccttgac 30361 ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 30421 gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct taagtctgat 30481 gtgaaagccc ccggctcaac cggggagggt cattggaaac tggggaactt gagtgcagaa 30541 gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag gaacaccagt 30601 ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg gggagcgaac 30661 aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt tagggggttt 30721 ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta cggtcgcaag 30781 actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt ggtttaattc 30841 gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta gagataggac 30901 gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg tgtcgtgaga 30961 tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc attcagttgg 31021 gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg tcaaatcatc 31081 atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag ggcagcgaaa 31141 ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt ctgcaactcg 31201 actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg aatacgttcc 31261 cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga agtcggtgag 31321 gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga agtcgtaaca 31381 aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat tttacggaat 31441 ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt gaaggaactt 31501 tgttccttga ataagttaag atgggcctgt agctcagctg gttagagcgc acgcctgata 31561 agcgtgaggt cggtggttcg agtccactca ggcccaccat cttatataac ggggccttag 31621 ctcagctggg agagcgcctg ctttgcacgc aggaggtcag cggttcgatc ccgctaggct 31681 ccaccaacgt gttctttgaa aactagataa cagtagacat cacattcaat tagtaacaca 31741 agatatcaca tagtgattct ttttaacggt taagttagaa agggcgcacg gtggatgcct 31801 tggcactagg agccgatgaa ggacgggacg aacaccgata tgcttcgggg agctgtaagc 31861 aagctttgat ccggagattt ccgaatgggg aaacccacca ctcgtaatgg agtggtatcc 31921 atatctgaat tcataggata tgagaaggca gacccgggga actgaaacat ctaagtaccc 31981 ggaggaagag aaagcaaatg cgattccctg agtagcggcg agcgaaacgg gattagccca 32041 aaccaagagg cttgcctctt ggggttgtag gacactctgt acggagttac aaaggaacga 32101 ggtagatgaa gaggtctgga aaggcccgcc ataggaggta acagccctgt agtcaaaact 32161 tcgttctctc ctgagtggat cctgagtacg gcggaacacg tgaaattccg tcggaatccg 32221 ggaggaccat ctcccaaggc taaatactcc ctagtgaccg atagtgaacc agtaccgtga 32281 gggaaaggtg aaaagcaccc cggaagggga gtgaaagaga tcctgaaacc gtgtgcctac 32341 aagtagtcag agcccgttaa cgggtgatgg cgtgcctttt gtagaatgaa ccggcgagtt 32401 acgatcccgt gcaaggttaa gcagaagatg cggagccgca gcgaaagcga gtctgaatag 32461 ggcgcatgag tacgtggtcg tagacccgaa accaggtgat ctacccatgt ccagggtgaa 32521 gttcaggtaa cactgaatgg aggcccgaac ccacgcacgt tgaaaagtgc ggggatgagg 32581 tgtgggtagg ggtgaaatgc caatcgaacc tggagatagc tggttctctc cgaaatagct 32641 ttagggctag cctcaaggta agagtcttgg aggtagagca ctgattggac taggggcccc 32701 taccgggtta ccgaattcag tcaaactccg aatgccaatg acttatcctt gggagtcaga 32761 ctgcgagtga taagatccgt agtcgaaagg gaaacagccc agaccgccag ctaaggtccc 32821 aaagtatacg ttaagtggaa aaggatgtgg agttgcttag acaaccagga tgttggctta 32881 gaagcagcca ccatttaaag agtgcgtaat agctcactgg tcgagtgact ctgcgccgaa 32941 aatgtaccgg ggctaaacgt atcaccgaag ctgcggactg ttcttcgaac agtggtagga 33001 gagcgttcta agggctgtga agccagaccg gaaggactgg tggagcgctt agaagtgaga 33061 atgccggtat gagtagcgaa agaggggtga gaatcccctc caccgaatgc ctaaggtttc 33121 ctgaggaagg ctcgtccgct cagggttagt cgggacctaa gccgaggccg aaaggcgtag 33181 gcgatggaca acaggttgat attcctgtac cacctcctca ccatttgagc aatgggggga 33241 cgcaggagga tagggtaagc gcggtattgg atatccgcgt ccaagcagtt aggctgggaa 33301 ataggcaaat ccgtttccca taaggctgag ctgtgatggc gagcgaaata tagtagcgaa 33361 gttcctgatt ccacactgcc aagaaaagcc tctagcgagg tgagaggtgc ccgtaccgca 33421 aaccgacaca ggtaggcgag gagagaatcc taaggtgatc gagagaactc tcgttaagga 33481 actcggcaaa atgaccccgt aacttcggga gaaggggtgc tctgttaggg tgcaagcccg 33541 agagagccgc agtgaatagg cccaggcgac tgtttagcaa aaacacaggt ctctgcgaag 33601 ccgtaaggcg aagtataggg gctgacgcct gcccggtgct ggaaggttaa gaggagcgct 33661 tagcgtaagc gaaggtgcga attgaagccc cagtaaacgg cggccgtaac tataacggtc 33721 ctaaggtagc gaaattcctt gtcgggtaag ttccgacccg cacgaaaggc gcaacgatct 33781 gggcactgtc tcaacgagag actcggtgaa attatagtac ctgtgaagat gcaggttacc 33841 cgcgacagga cggaaagacc ccgtggagct ttactgcagc ctgatattga atgttggtac 33901 agcttgtaca ggataggtag gagccttgga aaccggagcg ccagcttcgg tggaggcatc 33961 ggtgggatac taccctggct gtattgacct tctaacccgc cgcccttatc gggcggggag 34021 acagtgtcag gtgggcagtt tgactggggc ggtcgcctcc taaaaggtaa cggaggcgcc 34081 caaaggttcc ctcagaatgg ttggaaatca ttcgcagagt gtaaaggcac aagggagctt 34141 gactgcgaga cctacaagtc gagcagggac gaaagtcggg cttagtgatc cggtggttcc 34201 gcatggaagg gccatcgctc aacggataaa agctaccccg gggataacag gcttatctcc 34261 cccaagagtc cacatcgacg gggaggtttg gcacctcgat gtcggctcat cgcatcctgg 34321 ggctgtagtc agtcccaagg gttgggctgt tcgcccatta aagcggtacg cgagctgggt 34381 tcagaacgtc gtgagacagt tcggtcccta tccgtcgcgg gcgcaggaaa tttgagagga 34441 gctgtcctta gtacgagagg accgggatgg acgcaccgct ggtgtaccag ttgttctgcc 34501 aagggcatcg ctgggtagct atgtgcggac gggataagtg ctgaaagcat ctaagcatga 34561 agcccccctc aagatgagat ttcccattcc gcaaggaagt aagatccctg aaagatgatc 34621 aggttgatag gtctgaggtg gaagtgtggc gacacatgga gctgacagat actaatcgat 34681 cgaggactta accacatttt gaatgatgtc acacctgtta tctagttttg agagaacacc 34741 tctctaaagg cggaaggtaa ggaaactccg ctaagggctc tcacatcctg tgagaaacgc 34801 ccagtacctt catcctgaag gcatttgttt ggtggcgata gcgaagaggt cacacccgtt 34861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 34921 gtgagagtag gacgccgcca agcaagctta aacccagctt aatgagctgg gttttttgtt 34981 tactcaagat cgagaaaatc aaacaaatac aaacaccgag ggcttatata gcccatatac 35041 tgatttaaag tttcaaaaag gtctaaatag tgtatacaat atccgtttta aggggaggct 35101 aactgtacgg aggtggagaa gatggacgaa acagttaaac ttaatcatac atgtgtgatt 35161 tgtgatcaag agaagaatag aggcattcat ctttatacga aattcatatg cttagattgt 35221 gagagaaaag taatttctac atcaacttct gatcctgact atgcgtttta cgtaaaaaaa 35281 ctaaagagca ttcatacacc gccattatat tcatagacct gaaaaggtct ttttttgtac 35341 tcttaataat aaaaagaaga tgaaacttgt ttaaggattg aacgtagtag ataataatat 35401 taaaactgag tatagacaca ggagtcgatt atctcatgca gagatttttt cactttttgg 35461 tgtggagttt aactagcagt gcgacttttg ttttcattgg aatattgagc ttttttggtt 35521 taaaccagtc gattttttta tctattgttt atgggcttgc ttctggagca gccgtatata 35581 tagctggcat ctggaatgca agacggttat ttcttaaaaa gcatgaattg acaggaagag 35641 agtatgctta cattaagaaa aacttagagg aagcaaggca gaaaatggtc cgtcttagga 35701 aagccttgtt tcaggctaaa agcattcaaa tgtttaagca aaatgcagaa atgctaagga 35761 ttgtgagaag gatttatctc ctcaccaaaa aagagccaaa gcggttttat caggcagaac 35821 gattttttta tcaaactctc gattcggttg ttgaattgac agagaagtat gcttttctat 35881 catctcaccc aaaaaaaagc aaagaactgt cgatgtcgtt aagtgagaca cgcatcactc 35941 ttactgaatt gaccaagcgt ttagaggaag atttaactca agcaatgggt gatgaaattg 36001 acgagttgca gtttgaatta gacgcagcaa aacattcatt aaagaaataa gggaagaggg 36061 taagagcgat gaaccgagac caaagcgacc ttcatataga tgaattattg gcagatcctt 36121 ttggtggtaa catagagata ccaggttcgg aggctgtaaa agcagagaaa gagcaagtac 36181 ggcttgttga tgttcttcct gaggaaaaca aggaaaaagc aattcagctt gctggacaga 36241 ttgatcataa aaatatgcaa agcattgtct tatacggttc acaagctcaa tctaaactgc 36301 tgaacttttc tcatgatatg attaatcatg ttcaaaagaa ggatgtcggg gagattggcg 36361 aaatacttgg agagctgatg aaaaagctgg agcaagtaaa tcctgatgat ctccaatcta 36421 agaaaaaggg ttttttggca cgcatgtttg gaagagtatc aagttctctt caagaggtgc 36481 tgtctaaata ccaaaagacc agtgtgcaga tagacagaat cagcttgaag ctggagcact 36541 ctaaaaatgc tttaatcagt gacaacaagc tgttagagca gttatatgaa aaaaataaag 36601 aatatttcgc agcgctgaat gtttatattg ctgcaggaga actgaagctg gaggaattaa 36661 aaacaaaaac gattcctgaa ctgaagcaac aggctgaatc gagtgatcat aaccaaatgg 36721 ccgttcaaga ggtgaatgat ttaattcaat ttgctgaccg gttagataaa agggtgcatg 36781 atttgctgct gagcaggcaa attacaatcc aaagtgcacc gcaaatcagg ctgattcaaa 36841 atacaaacca agcgttagct gaaaagattc agtcatccat tgtgacagcg attccgttat 36901 ggaaaaatca agttgccatt gcactgacgc ttttaaggca gcgcaatgca gtggatgcac 36961 agcagaaagt atctgataca accaatgagc ttttgctgaa aaatgcggag cttttaaaaa 37021 ccaatacaat tgaaactgca cgggcaaatg aaagaggcct tgttgatata gataccttga 37081 agaaggtgca ggaaagctta ataagcacgc ttgaagaaac actgactata caagaagaag 37141 gacgaatcaa acgccgtcag gcagaagaag agctcatgat gatggaaggc gacctgaagc 37201 aaaagctgat tacaataaag gaaagatgat taccagtaag tctggcttta agttctgtca 37261 gaggcacgat ataataaggt gtaagaagac acattcaaag gattgttttc atgaacacac 37321 ctttatataa agcattaatt caacatgcga gaagaaattc tcattcattt catgttccgg 37381 gacatcacaa tggagatgtc ttttttgatg acgctaagtc aatattcgat ccgcttctca 37441 ccattgatgt aactgaactg gcaggactgg atgatctcca tcatccttct ggggtgatta 37501 aggaagctca ggagcttgcc agtcaattat atggatcggc ggaaagtttt tttctggtaa 37561 atggtacgac tgtcggaaac ttagcgatga ttttatctgt ttgtgaacct ggtgatacaa 37621 ttctggttca aagaaactgt cataaatctg tatttcatgc tgttgatttg tccggtgctg 37681 agccggttta tcttgcacct gacgttgatt cagcgatgca tgtgcctacg catgttccgc 37741 ttggaacaat taaagaggcc ctggaagcat atccagatgc gaaaggcttg gtactgacca 37801 atccgacata ttacggacat agtgctgatt tgactgagat cattactgaa gcccatcatt 37861 acgggattcc tgttttggtc gatgaagcgc atggcgcaca ttttatttta ggtgagcctt 37921 ttccggtctc agctttaaaa atgggggcag atattgttgt tcagtcggcc cacaaaacgt 37981 tgccagccat gacgatgggt tcttatttgc atctcaacag cagctgcagg attaacaggg 38041 atcgggtggc agagtattta aaccgattac aaagcagcag cccgtcttat ccgattatgg 38101 cttcgttaga tattgcccgc gcttatgtac agcatattat agaagaacaa aagctttctg 38161 acattctgca gcggatagaa acacttaaac aaacgtttga ttcacttaca aatgcagaag 38221 ctgttaaccc tgctaatcca ctgatcatca cggatccgct aaagctcaca attcgttcaa 38281 aacgcgggca ttctggctat acgctgcaaa gcattttaga gcgtgccaac atattcactg 38341 agcttgctga tgaaaatcaa gttctgctcg ttctcccatt gggaggaaaa cggagaataa 38401 acgctgaaat cattagaagc atcgatgaag agattgagaa aacgcctccg gatcagacgt 38461 ttgtttctgc agaatggggt gtgcagcctg ttactgtctt gccttatcca aaaaaggtct 38521 tacattcgtt taagaaagaa tatgtgagct ttgaggaagc agctggccgg cttaatgcag 38581 aagatatcat cccttatcct ccgggtatcc cgatgattat ggcgggagaa agaataacaa 38641 aagaaagtgt gcaaaagctc agccgcttga tcagcatgaa aacgcatgtt caagggaata 38701 tgaaaatcaa agagaaacaa ctacttgttt atatagaaga ggagaaatca tgagcggttt 38761 atttattaca ttcgaaggtc ctgaaggtgc agggaaaacg actgttctgc aggagatcaa 38821 aaacatactg acagcagaag gccttcaggt tatggcaact cgagagccag gcggaataga 38881 tattgcagaa caaattagag aggttattct gaatgagaac aatatattaa tggacccaaa 38941 aacagaagct ctcttatatg cggctgcaag acgccagcat ttagttgaaa aagtaaaacc 39001 tgctttagaa caggggttta tcgttctttg cgacagattc atagacagtt ctcttgcgta 39061 tcaaggatat gcaagagggc ttggaattga tgaggttctg tccattaatg aatttgccat 39121 tggagatatg atgccccatg taacggttta tttttcaatt gatccggaag aaggactgaa 39181 gcgtatttac gcaaacggct cacgggagaa aaacaggctc gatttagaaa aactggactt 39241 tcatacaaaa gtacaagaag gttatcaaga gctgatgaag cgatttccgg aaagatttca 39301 ttcagttgat gccgggcaat ccaaagacct cgtcgttcag gatgttctaa aggtgatcga 39361 tgaagcgttg aaaaaaattc aattgtgacc tgtttcccaa tagttgatat aataatgtaa 39421 acgagatcac gttgtttcca atctaaagga ggccttcaca gatgaaattg atagtggcag 39481 ttgtacaaga tcaggacagc aacagacttt tgaaaacctt aacggatcac aacttcagag 39541 tcacaaagct tgcaacgaca ggaggatttc ttaaatcagg caatacaacg tttatgatcg 39601 gtgtcgagga tatacgcgtc aataaagcgt tgagtctcat taaagaaaac gggcagaaac 39661 gtgatcagat gattgcccct gtatctccaa tgggtggaaa tgctgattcc tatgtccctt 39721 atccagtcga agttgaagtt ggcggagcga cagtatttgt ccttccagtc gatgaatttc 39781 atcaatttta aggatctgaa actgtgaaaa ttaataaaga tatacgtaca tttatagata 39841 ataagcagat tccctctgtg aaaacatctg agatcacagc atcgtttaaa acatcaatgg 39901 aaaaccaaag cagcaaaatg aagcttgatc agcttaccag gctgttatct gatatagaag 39961 catttggaaa aaggctaacg aaatctcgga attttaaaga cttagcgaga tttaaaggac 40021 ttgtgaaacg ttttgtcaaa gaagctgtgg acagcggtct ttcacatgaa acatcgaaaa 40081 gctttgacct ttacgggaac agcagaacgc tgggacttgt gaaagaaata gatgacaaat 40141 tgatacagct tacggaagag atgatggatc aggaaaaacc ggcaattgat ttgctggagc 40201 gtattggcga aataaaaggt ttattaatta acctttacac atagagagtg atacaatggc 40261 aatatcctgg aaggaaatga acgagcttca gcccagagtg atgaagcttt tatataatag 40321 tattgagaag gacagactat cacacgctta tttgtttgag gggaaaaaag gaacaggcaa 40381 gcttgatgcc gcgctgcttc ttgcaaaaag cttcttttgt ctggagggtg gcgcggagcc 40441 ttgtgagagc tgccgaaact gtaaacggat agagtcaggg aaccatcctg atctccatct 40501 tgttcagcct gatggcttat caatcaaaaa ggcgcaaatt caagcgctcc aagaagagtt 40561 ttctaagaca ggacttgaat cgcataaaaa gctgtatatt atttcgcacg cagatcaaat 40621 gacagcaaat gcggcgaaca gcctgctgaa atttttagaa gaaccgaaca aagacacaat 40681 ggccgtcctc atcactgagc agccccaaag gttattggat accatcattt caagatgcca 40741 aacccttcct tttcagcctt tgcagccgaa agcaattgaa gacagactga tcgaacagga 40801 cgtctcgcct catatggcaa ggcttctggc caacatgact aataatgtag cagaagcagt 40861 cgaattaagt cgaaatgatg agtttgcaga gtctagagcg aaagtgataa aattgtatga 40921 agtcctacac cagcggaaag gacatgcttt tttctttatt caagatcaat ggatgccctt 40981 tttcaaagaa aaaacccatc aagaaatggg tcttgatatg ctcttattga tatatcgtga 41041 tgtgttgtcc atccaaatag gaaatgaaga taaattgatt tatcaagact tattccaatc 41101 aataaaacag catgcgctac aatcaacaca acaaagcgtt acgaatcaga tacttgctgt 41161 tttagaagca aagaaacggc ttcattccaa tgtgaatgta caaggattaa tggagcactt 41221 ggtgttaatg ttgcaggagg gataagcttg tacaatgtaa ttggtgtccg ctttaagaaa 41281 gcgggtaaaa tatattattt tgatccgaat ggatttcata tagaacatga cagctgcgta 41341 attgtagaaa ctgtcagagg cgttgagtac ggccaggtcg taattgcaaa taaacaggtg 41401 gatgagcatg atgtggtgct tccccttcga aaagtgatac gtgtggcaga cgatcgcgat 41461 cttctcattg tagaagaaaa taaacaggaa gcactatcag catttgatat ctgccaaaag 41521 aaagtgattg agcatggctt ggatatgaag ctggtcgatg ttgaattcac gtttgatcgc 41581 aataaagtca ttttttactt cactgctgac ggccgagtcg actttagaga gcttgtaaag 41641 gatttggctt ctatctttaa gacaagaatt gagctgcgcc aaatcggagt gagggatgag 41701 gcaaaaatgc tcggaggaat cggtccttgc ggaagaatgc tttgctgttc aacgtttctt 41761 ggagattttg aacccgtttc cattaaaatg gccaaggatc agaacttgtc tttaaatcct 41821 acgaagattt cgggtctttg cggacgattg atgtgctgtc taaaatatga gaacgatgag 41881 tatgagacgg caaaagaaca gcttccggat ataggagaaa tgattacgac agcaaacggt 41941 cccgcgaagg tcgtcggact aaatattctg gaacgggtgc ttcaggtgga actgataaac 42001 cgtgaaaaag tgatagaata tacttgggaa gagctcttgg aagagggcgt cgtatccgca 42061 caaaccacag attaacgagg tgtggaacct tggataaaaa agagttattt gatacagtca 42121 ttaacttaga agaacaaatt ggctcactgt accggcagct gggggatttg aagcagcata 42181 tcggtgagat gattgaggaa aatcatcatt tacagcttga aaacaagcat ttgcgcaaac 42241 ggctggacga tacgacgcag cagattgaaa agttcaaagc tgataaaaaa gaatcaaaaa 42301 cacagaagac agagcaaact gatatagggg aaggatatga taatctggca cgtctgtatc 42361 aagaaggatt tcatatctgc aatgtccact atggaagtgt tcgaaaagag gattgtcttt 42421 tctgtctgtc attcttaaat aaaaaatagg gaaaaggctt ccgcataaga cgggagcctt 42481 tttcaaaggt actgaaagga taagaagatg gtttcattac atgatgatga aagattagat 42541 tatttgctgg cagaggacat gaaaatcata caaagcccaa cagtgtttgc tttttcgttg 42601 gacgctgtgc ttctgtccaa atttgcgtac gttccgattc aaaaagggaa aattgttgat 42661 ttatgcaccg gcaatggtat tgtgccgctg ctgctcagta caagatcaaa agcagacatt 42721 ctgggagtcg aaattcaaga aagactgcat gatatggctg ttcgcagcgt ggagtataat 42781 aagttggacg atcagatcca gatcatacat gatgacctga aaaacatgcc ggagaaactt 42841 ggacataatc gatatgatgt tgtcacctgc aatccgccgt attttaaaac gccgaaacaa 42901 actgaacaaa acatgaacga gcatctccga atcgcaagac atgaaatcca ctgcacgctg 42961 gaggatgtca tttcagtcag cagcaagctg ctcaagcaag ggggaaaagc agctcttgtt 43021 caccggccgg gaaggcttct ggagattttt gaactgatga aggcttatca aatcgagccg 43081 aaacgtgtac aatttgtcta tccgaagcaa gggaaagaag ccaataccat tttggttgaa 43141 ggtatcaaag gcgggcgccc ggatttgaaa attcttcctc ccttattcgt atatgatgaa 43201 caaaatgaat atacaaaaga aatcaggacc attttatatg gagacaaata accatttctt 43261 ctacgtcgtg aaatgtaagg acaatagctg gtatgccggg tataccaacg atctgcataa 43321 acgagtgaaa acgcacaatg atggaaaggg cgcaaagtac acaaaagtaa gacgtccggt 43381 tgaattaatt tttgccgaga gcttttcaac aaagcgggaa gctatgcagg cggaatatta 43441 tttcaaaaaa ctaactcgga agaaaaaaga gctttatata gaagaaaagc ggaacagcaa 43501 ggaggctgta tatgttaagg cgccaaatga gctttaatgg aaagtcggac atggggattc 43561 tttacttggt cccaacccca atcggaaatt tagaggatat gacattccgg gcgatcgaca 43621 cgctgaaatc agtggatgcg attgctgcgg aagatacgag gcaaacgaaa aagctttgtc 43681 atgtatatga aattgaaaca ccgctcgtca gctatcacga acacaataaa gaaagcagtg 43741 ggcacaaaat tattgaatgg ctgaaatcgg gaaaaaacat tgctcttgtc agtgatgccg 43801 gtctgccgac gatttctgat cccggagcgg aaattgtaaa ggattttacg gatataggcg 43861 gttatgttgt tccgttgccg ggagcaaatg ctgcattaac agctcttatt gcttcaggta 43921 ttgtaccgca gccttttttc ttttacggtt ttctcaacag acagaaaaaa gaaaagaaga 43981 aggagcttga agcccttaaa aaacggcagg aaacgatcat tttttatgaa gcgccccaca 44041 gattgaagga aaccttgtca gcgatggcag agatattagg agatcgggaa attgctgtaa 44101 cacgtgaact cactaagaaa tatgaagagt ttatccgagg aaccatatct gaggtcattg 44161 gatgggcaaa cgaggatcag atacgcggcg agttttgtct tgtcgtagaa ggaagtaata 44221 atgaagaggt agatgaggaa gaacaatggt gggaaaccct cactgcgaaa gaacatgtcg 44281 agcattacat ttcgaaaggc gctacgtcta aagaagctat taaaaaagca gcagtcgatc 44341 gcaatgtacc aaagcgtgaa gtgtacgatg cttaccatat taagcaataa aaaaacgttc 44401 ttgtgtcata acaagaacgt tttttgtaca agaaatgatt atttaaggtt ttgaagctgg 44461 ttttggattt cgctgatgat ttgctcagcg ccttctttac taagaaccaa tttaccgcct 44521 gcaagtttaa ggttatcatc agaaacttca ccagttactt ggcaagtcat gtttggttta 44581 tattttttaa ggatgatttt ttcatcatca acatagattt caagagcatc tttttctgcg 44641 attccaagag tacgacgcag ttcgatagga ataactacac gtcctaattc atcaacttta 44701 cgtacaatac cagtagattt cataaacatt ctcctcccaa gagatactta tttgtttaaa 44761 ttatattttt cttcgtcatt attcgacaaa atccttacct tcatagcata acaaggtttc 44821 caataatcgt caatcatttt gtttactatt gattgtaaga attagttctt atagtcagta 44881 atgtcttgga aactaccgaa ataacagcat tttataaata tttaataaag ctattatcct 44941 actaaaaatc cttttaaatc aagactttcg aaccaaagtt ttttatttca tttgattata 45001 tacgacaaaa ttcgacacga acagactttt tttattttca ttaaagattt ttaattttaa 45061 ttattctttt tcagggcgta tgtatatatt cttgatctta aaggctaaga tggtatcata 45121 gataaaggat aaatataaat aatattcata tatgatttgc acttatcgcc gctctcgtcc 45181 tttgggcggg agctttttga cattctgatt aggaggtttc aagatgccgc aagaaaacaa 45241 tacattttac attacaacac cgatttatta tccgagcgga aaattacata tcggccatgc 45301 atatacgaca gtcgcaggag atgcaatggc acgttacaaa agattaaaag ggttcgatgt 45361 tcgctattta acgggaacgg acgagcatgg acaaaagatc cagcaaaaag ctgaacagga 45421 aaacattaca cctcaggagt atgtggatcg cgcagcggca gatattcaaa aactgtggaa 45481 gcagcttgaa atctcaaacg acgactttat ccgcacgaca gaaaaacggc ataaagttgt 45541 cattgaaaaa gtgtttcaaa agcttcttga taacggggac atctatcttg atgagtatga 45601 aggctggtac agcatccctg atgaaacgtt ctacacggaa actcagctcg ttgatattga 45661 gcggaatgaa aagggagagg tcatcggcgg aaaaagccct gacagcggtc acccagttga 45721 attgatcaaa gaggaatctt atttcttccg catggggaaa tacgcggatc gtcttctgaa 45781 atactatgaa gaaaacccga cattcattca gccagaatca cgcaaaaacg aaatgattaa 45841 taactttatc aaacctggac ttgaggattt ggcagtatca cgtaccactt ttgattgggg 45901 cgtgaaggtg ccggaaaatc caaagcatgt tgtatatgtt tggattgacg cactatttaa 45961 ctatttaacg gcactcggtt atgatacaga aaatgatgag ctttatcaaa aatattggcc 46021 tgccgatgtt catttagtcg gtaaggagat tgtacgattc catactattt actggccaat 46081 tatgctgatg gcgctggatc ttccgctgcc aaagcaagta ttcgcgcatg gctggctttt 46141 gatgaaagac ggaaaaatgt cgaaatcaaa aggaaacgtt gtagatccgg ttacattaat 46201 tgaacgctat ggtttagacg aacttcgcta ttacttgctt cgcgaagtgc cgttcggatc 46261 agacggtgtt ttcacgccgg aaggatttgt tgagcgaatc aactatgatt tagcgaatga 46321 tttaggaaat ctattgaatc gtactgttgc gatgattaat aagtattttg acggacaaat 46381 cggttcttac aaaggtgctg ttacggaatt tgaccatacg ctcacttctg ttgctgaaga 46441 aacagtgaaa gcttatgaga aagcaatgga aaatatggag ttctcggtag cactttcgac 46501 tttatggcag ctcatcagcc gcacaaacaa atacattgat gagacagctc catgggtgct 46561 tgcgaaagat ccggcaaaag aagaagaatt gcgatcagtt atgtatcatc tcgctgaatc 46621 attgcgtatt tcagcggtac tgcttcagcc attcttaaca aaaacacctg aaaaaatgtt 46681 cgagcagctg ggcattactg atgaatcttt aaaagcttgg gacagcatta cagctttcgg 46741 ccagctgaaa gatacaaaag tacaaaaagg cgagccattg ttccctcgtt tagaggcaga 46801 agaagaaatt gcttacatca aagggaaaat gcaaggttca gcaccagcga aagaagaaac 46861 aaaagaagaa gagcctcaag aggtcgatcg tttacctgaa attacgattg atcaatttat 46921 ggatgtagag cttcgcgtag ctgaggtcat tgaggcagag ccagtgaaaa aagcagaccg 46981 tttattgaag ctgcagcttg atcttggttt tgaaaagcgc caagtggtat ccggcattgc 47041 gaagcattat acgcctgaag agcttgttgg aaaaaaactc gtttgtgtaa caaatctaaa 47101 accggttaaa ctcagaggag agctttctca aggtatgatc cttgcaggag aagcagacgg 47161 cgttttaaag gtcgtatcta tcgatcagtc gttaccaaaa ggcacaagaa ttaaataatg 47221 ataaacaaaa ggtgtttcac gtgtaacaat tcgtcgaaca ccttttgtgt ttcgacaaga 47281 aaggagtttt tcacttatgt tgtttgacac tcacgcgcat ttaaatgcag aacaatatga 47341 tactgatctt gaagaggtta ttgaacgggc aaaagctgaa aaagttgaac gaattgtcgt 47401 agttggtttt gaccgtccga cgattacccg tgcgatggaa atgattgagg aatatgattt 47461 tatttatgca gccattggct ggcaccctgt tgacgctatt gacatgacag aggaagactt 47521 agcgtggatt aaagagcttt ctgctcatga gaaagtggta gcgatagggg aaatgggact 47581 ggattatcat tgggataaat cacctaaaga tattcaaaaa gaggtgttta gaaatcaaat 47641 cgccttagcg aaagaggtca atttgcctat tatcattcat aaccgtgatg caacggagga 47701 tgtcgtgacc attttgaaag aggaaggcgc agaagctgtg ggcggaatca tgcactgctt 47761 tacaggaagt gcggaagtgg caagagaatg catgaaaatg aatttttatt tatcatttgg 47821 gggaccggtg acatttaaaa atgcgaagaa accgaaggaa gtagtgaagg aaattcccaa 47881 tgaccggctg ctgattgaaa cggactgccc gtttctcaca ccgcaccctt tccgcgggaa 47941 aagaaatgag ccaagctatg tgaaatatgt ggcagaacaa atcgccgaat taaaagaaat 48001 gacctttgaa gagattgctt ccatcacgac tgaaaatgcg aaaagacttt tccgtataaa 48061 ctgacaaaaa acgctagcgg gttttgtaag agcttgtccc ttacagcgtt tttctataaa 48121 agttctacat gctttcttct cctcatagga taggtttgtc gacaagtctt tcttccgttt 48181 ctcagtgtat ttcaggataa tgaagaggac actgagcttt tgggagaaag agaagggagg 48241 gttgacagcc ttttagatac tctatataat ctctccgagg agaaggaggc gtttttcatc 48301 acacaaaaaa tgaaaaagct gttttccgta aagcttagca aaagcaaagt cattctggtt 48361 gctgcttgtt tgcttttggc aggaagcggg actgcgtacg cggctcatga gctgacgaaa 48421 caatcagtct cagtttctat caatggcaaa aagaaacata tacgcacaca tgcaaataca 48481 gtcggtgatc ttttggagac gcttgatata aagacaagag acgaagacaa gatcacacct 48541 gctaaacaga caaagataac agcagacatg gacgttgtgt atgaggctgc aaaacctgtg 48601 aagcttacaa taaacgggga agaaaagacg ttatggtcaa cagcaaaaac ggtcggtgca 48661 ttactggacg aacaagatgt tgatgtgaaa gaacaagatc aaattgatcc cgcaatagat 48721 acagatattt cgaaagacat gaagattaac atagagcccg catttcaggt tactgtgaat 48781 gatgcaggga aacaaaagaa gatctggacg acttcgacta cggtcgctga ctttttaaaa 48841 cagcaaaaga tgaacataaa agacgaagat aaaatcaagc ctgcgttaga tgcaaagctg 48901 acgaaaggaa aggctgatat tacaattact cgtatcgaaa aggtcaccga tgtagttgaa 48961 gagaagattg cgttcgatgt gaaaaagcaa gaagacgctt ctcttgaaaa agggaaagaa 49021 aaggtcgtcc aaaaaggaaa agaaggcaag ctaaaaaaac atttcgaagt cgttaaagaa 49081 aacggtaaag aagtgtccag agagcttgta aaagaagaaa cagctgaaca aagcaaagat 49141 aaagtgattg ctgtcggcac aaagcaaagc agtccaaaat ttgaaacggt cagtgcttca 49201 ggtgattcaa aaacagttgt gtcccgcagc aatgaatcaa caggcaaagt catgactgta 49261 tcatctacgg cttatacggc aagctgcagc ggttgttcag gacatacagc gacaggcgtc 49321 aatttaaaaa ataatccgaa tgccaaagtc atcgctgtgg atccaaatgt cattccgcta 49381 ggctccaaag tccacgtgga aggctatgga tatgccattg ctgcagatac cggttcagcg 49441 attaaaggga acaagataga cgtctttttc ccagagaaat catcggcgta ccgatgggga 49501 aataaaacag tcaaaattaa aatcttaaat tagtatatac ttatgtattc agagggtttt 49561 gcgccctctg tttttttcgt tataatagac aaagtgcatt ttctgcttat tagacgctcg 49621 atataagaaa aagtttcatg aatatacaaa agtttttatt ttgtcttgga ggaaataatg 49681 aaaattaaag agatcattgt ggtcgagggg cgtgacgata cggcccgcat caaattggct 49741 gttgatgcag acacaattga aacaaatggt tcagccatcg atgatcatgt gattgaccaa 49801 atccgtttgg cccagaagac gagaggcgtc attattttaa cggatccgga ctttccggga 49861 gagaagattc gcaaaaccat ctcagaggct gtacccggct gtaagcatgc atttttgcca 49921 aaacatcttg ccaaacctaa aaacaagcgg ggaattggtg tggagcatgc atcggttgaa 49981 agcattaggg catgtttaga aaatgtgcat gaggagatgg aagcgcagcc gagtgacatt 50041 tcagctgagg atttgattca tgccggacta ataggcgggc ctgcggccaa atgccgccgg 50101 gaacgactgg gtgatctgtt gaaaatcggc tatacaaatg gcaaacagct tcaaaaacgg 50161 ctgcaaatgt ttcaaattaa aaaaagtgat tttatgagtg cgctcgatac cgttatgcgg 50221 gaggaacaga atgaataaag atattgcgac accgattaga acgaaagaga tactgaagaa 50281 atacggtttt tcttttaaaa agagcttagg acagaatttc ttaattgata cgaacatttt 50341 aaacagaatt gttgatcacg cggaagtgac ggagaaaaca ggtgtcattg aaatcggccc 50401 gggaatcggg gctttaaccg aacagcttgc caagcgggcg aaaaaggtcg tggcatttga 50461 gattgaccag cgattattgc cgattctgaa ggatacactg tcaccttacg aaaatgtcac 50521 tgtcattcat caggacgtgt taaaggctga tgtcaaatca gtcattgaag aacaatttca 50581 agattgtgat gagatcatgg tagttgccaa ccttccttat tacgtaacaa caccgattat 50641 catgaaactg cttgaagaac atcttccgct gaaagggatt gtggttatgc tgcaaaaaga 50701 agtggctgag cgcatggcgg ctgatccttc atctaaggaa tacggctcgc tttcaatcgc 50761 ggtgcagttt tatacagaag ccaaaacggt gatgatcgtc ccgaaaaccg tatttgttcc 50821 tcagcctaat gtcgattccg cagtcattcg tctgattctc cgagacggcc cggcagtgga 50881 cgtggaaaac gaatcctttt tctttcagct catcaaggca agctttgcac agcgccgtaa 50941 aacgctgctc aataacttag ttaacaatct gcctgaagga aaagcacaaa aatcaacgat 51001 tgaacaagtg ctcgaagaaa caaatattga cggtaagcgc cgaggtgaat ccctgtctat 51061 tgaggaattc gcagcgctgt ctaacggatt gtataaagcc cttttctaaa agggcttttt 51121 gttttgcgca ccacatggac tgccgctaca taggctagag aaggaccttt cattcaatga 51181 taagaaaaaa cttggactca gcgaaaaaag gcgctttctc aaggctcttt ctttcatgat 51241 gaggcttagt ctatgtgtgg agtgaggaac gtgcaatttc aaatagggga tatggtagcc 51301 agaaaatcct atcagatgga tgttttgttt cgaattatag gaatagagca aacaagcaaa 51361 ggaaattcaa ttgccatttt gcatggagat gaagtcaggc tgattgctga ttcggatttt 51421 tctgatctgg tggcagtgaa aaaggatgag cagatgatgc ggaaaaagaa agatgagagc 51481 agaatgaatg agtcgctcga attgctccgc caagattata agctgctcag agaaaagcag 51541 gagtactatg cgacaagcca atatcagcat caggagcatt atttccatat gccgggcaaa 51601 gtgcttcatc tggatggtga cgaagcatat ttgaaaaaat gcctgaatgt ctataaaaaa 51661 attggagtgc cggtctatgg catccattgc catgaaaaga aaatgtctgc ttctattgaa 51721 gtattgctcg acaaatatcg acctgacatc ctggtgatca cagggcatga tgcgtactcg 51781 aagcaaaagg gcggtattga tgatttgaat gcgtacagac attctaagca ctttgttgaa 51841 acagttcaaa cagcccgaaa aaagatccct cacttagatc agcttgttat ttttgcgggg 51901 gcctgccaat cccattttga atcactcatc agagcgggtg cgaattttgc aagttcaccg 51961 tcaagagtca atattcatgc gcttgatccg gtatatatcg tcgcgaagat cagctttacg 52021 ccgtttatgg aacggattaa tgtatgggaa gtgctccgta atacgctgac aagagagaaa 52081 gggcttggag gtattgaaac aagaggagtt ctgagaattg gtatgcctta taagtccaat 52141 taacagttga aaacctgcat aggagagcta tgcgggtttt ttattttaca taatgataca 52201 taatttaccg aaacttgcgg aacataattg aggaatcata gaattttgtc aaaataattt 52261 tattgacaac gtcttattaa cgttgatata atttaaattt tatttgacaa aaatgggctc 52321 gtgttgtaca ataaatgtag tgaggtggat gcaatggcga agacgttgtc cgatattaaa 52381 agatcgcttg atgggaattt aggtaaaagg ctgacgttaa aagcaaacgg tggccgccga 52441 aaaacgattg agcgttcggg cattttagct gagacgtacc cttctgtttt tgtgatacaa 52501 ctagatcaag acgagaactc gtttgaaaga gtttcataca gttatgctga tattttgact 52561 gagactgttg agctgacatt taatgatgac gccgcaagct cagtggcatt ttaacgggca 52621 gtgaaccttt tgtttactgc tttttgtttt gccctttttt ggtttccaat aattttaacg 52681 aaagttccat ctgatttaac aaaagataaa acagtcacat attatcgtga cgtgcacgaa 52741 tggctatcac ttctaaaaaa ggagttgttt cgtttgggca gacgtcgtgg agttatgtca 52801 gatgagttta aatatgagct ggctaaagac cttggttttt atgacacagt aaaaaatgga 52861 ggctggggtg aaattcgggc ccgcgatgcc ggtaacatgg tgaagcgtgc tattgaaatc 52921 gccgaacagc aaatggctca gaatcagaat aaccgataag gatgtgaccc gggggacgtg 52981 ctgttccctg gtttttttat tttggatata aatacataat gggctgaata tggatatgtt 53041 catcctgtac ttcaaatgtg atacaatgtt catacttatg tttagatgga gaagtaggtg 53101 aaagctatgc gtattttaga aaaagcgcca gctaagatca atctgtcact tgacgtcacc 53161 cgaaaacgcc cggatggcta tcatgaagtc gaaatgatca tgacgacaat tgatttagct 53221 gatcgaattg aattgacgga gcttgcagag gatgaagtga gggtttcctc ccacaaccga 53281 tttgtgcctg atgaccaaag aaacttagct tatcaggctg ccaagctgat caaggacaga 53341 tacaacgtga aaaagggagt ttccatcatg attacgaagg taattccggt ggctgccggt 53401 cttgccggcg gaagcagtga tgcggcggcg acactcagag ggctgaacag actgtggaat 53461 ttaaatctgt ccgcggaaac gcttgctgag cttggagcgg aaattggctc tgacgtttca 53521 ttttgtgtct atggcggaac tgcattagca acagggcgcg gcgagaaaat taaacatatc 53581 agcacgcctc cgcactgctg ggtcatttta gcgaagccga caatcggtgt ttcaactgct 53641 gaagtgtaca gagcgctgaa actggatggt atagagcatc ccgatgtaca aggcatgatc 53701 gaggcgatag aagaaaagag ttttcagaag atgtgcagcc ggttaggcaa tgtgcttgaa 53761 tctgttacac tcgatatgca tcctgaagtt gcgatgatca aaaaccagat gaaacgcttt 53821 ggtgcagatg ccgtgttaat gagcgggagc ggcccgacag tgtttggact ggttcagtat 53881 gagtcgaagg tgcagagaat ttataacggg ttaagaggct tctgcgatca agtttatgcg 53941 gtgagaatga tcggcgaaca gaacgctctt gattaaatcc gtatgttaag ttatattgat 54001 cttaaaatat tcggattttg ggggtgagtt catgaagttt cgtcgcagcg gcagattggt 54061 ggacttaaca aattatttgt taacccatcc gcacgagtta ataccgctaa cctttttctc 54121 tgagcggtat gaatctgcaa aatcatcgat cagtgaagat ttaacaatta ttaaacaaac 54181 ctttgaacag caggggattg gtactttgct tactgttccc ggagctgccg gaggcgttaa 54241 atatattccg aaaatgaagc aggctgaagc tgaagagttt gtgcagacac ttggacagtc 54301 gctggcaaat cctgagcgta tccttccggg cggttatgta tatttaacgg atatcttagg 54361 aaagccatct gtactctcca aggtagggaa gctgtttgct tccgtgtttg cagagcgcga 54421 aattgatgtt gtcatgaccg ttgccacgaa aggcatccct cttgcgtacg cagctgcaag 54481 ctatttgaat gtgcctgttg tgatcgttcg taaagacaat aaggtaacag agggctccac 54541 agtcagcatt aattacgttt caggctcctc aaaccgcatt caaacaatgt cacttgcgaa 54601 aagaagcatg aaaacgggtt caaacgtact cattattgat gactttatga aagcaggcgg 54661 caccattaat ggtatgatta acctgttgga tgagtttaac gcaaatgtgg cgggaatcgg 54721 cgtcttagtt gaagccgaag gagtagatga acgtcttgtt gacgaatata tgtcacttct 54781 tactctttca accatcaaca tgaaagagaa gtccattgaa attcagaatg gcaattttct 54841 gcgttttttt aaagacaatc ttttaaagaa tggagagaca gaatcatgac aaaagcagtc 54901 cacacaaaac atgccccagc ggcaatcggg ccttattcac aagggattat cgtcaacaat 54961 atgttttaca gctcaggcca aatccctttg actccttcag gcgaaatggt gaatggcgat 55021 attaaggagc agactcatca agtattcagc aatttaaagg cggttctgga agaagcgggt 55081 gcttcttttg aaacagttgt aaaagcaact gtatttatcg cggatatgga acagtttgcg 55141 gaagtaaacg aagtgtacgg acaatatttt gacactcaca aaccggcgag atcttgtgtt 55201 gaagtcgcga gactcccgaa ggatgcgtta gtcgagatcg aagttattgc actggtgaaa 55261 taataagaaa agtgattctg ggagagccgg gatcactttt ttatttacct tatgcccgaa 55321 atgaaagctt tatgacctaa ttgtgtaact atatcctatt ttttcaaaaa atattttaaa 55381 aacgagcagg atttcagaaa aaatcgtgga attgatacac taatgctttt atatagggaa 55441 aaggtggtga actactgtgg aagttactga cgtaagatta cgccgcgtga ataccgatgg 55501 tcgcatgaga gcgattgcat ccatcacgct ggatcacgaa tttgttgtac atgatattcg 55561 tgtgattgat ggaaacaatg gtcttttcgt tgcgatgccg agtaaacgca cccctgatgg 55621 agagttccgc gatattactc atcctattaa ttcaagcacg cgaggaaaga ttcaagatgc 55681 cgtgttaaat gagtatcatc gtctgggtga cactgaagca ttagaattcg aagaagctgg 55741 agcttcttaa aaaataacca aaaagcaagg actgctgaaa gggctgacat aagccttttg 55801 ccggcggtcc ttttttaatt ctgatttttc aaacttagtt gcactcaata gaaaattctt 55861 gcacttcatg aagtctcctt gaaatcagaa gatatttagg atatattttt ctatggataa 55921 aagggatatt ggaggccaat aaatggataa gcggtttgca gttgttttag cggctggaca 55981 aggaacgaga atgaaatcga agctttataa agtccttcat ccagtttgcg gtaagcctat 56041 ggtagagcac gtcgtggacg aagccttaaa attatcttta tcaaagcttg tcacgattgt 56101 cggacatggt gcggaagaag tgaaaaagca gcttggtgat aaaagcgagt acgcgcttca 56161 agcaaaacag cttggcactg ctcatgctgt aaaacaggca cagccatttc ttgctgacga 56221 aaaaggcgtc acaattgtca tttgcggaga tacgccgctt ttgacagcag agacgatgga 56281 acagatgctg aaagaacata cacaaagaga agcgaaagct acgattttaa ctgcggttgc 56341 agaagatcca actggatacg gccgcattat tcgcagcgaa aacggagcgg ttcaaaaaat 56401 agttgagcat aaggacgcct ctgaagaaga acgtcttgta actgagatca acaccggtac 56461 gtattgtttt gacaatgaag cgctatttcg ggctattgat caggtgtcta atgataatgc 56521 acaaggcgag tattatttgc cggatgtcat agagattctt aaaaatgaag gcgaaactgt 56581 tgccgcttac cagactggta atttccaaga aacgctcgga gttaatgata gagttgctct 56641 ttctcaggca gaacaattta tgaaagagcg cattaataaa cggcatatgc aaaatggcgt 56701 gacgttgatt gacccgatga atacgtatat ttctcctgac gctgttatcg gaagcgatac 56761 tgtgatttac cctggaactg tgattaaagg tgaggtgcaa atcggagaag atacgattat 56821 tggccctcat acggagatta tgaatagtgc cattggcagc cgtacggtta ttaaacaatc 56881 ggtagtcaat cacagtaaag tggggaatga tgtaaacata ggaccttttg ctcacatcag 56941 acctgattct gtcatcggga atgaagtgaa gatcgggaat tttgtagaaa ttaaaaagac 57001 tcaattcgga gaccgaagca aggcatctca tctaagctat gtcggcgatg ctgaggtagg 57061 cactgatgta aacctgggct gcggttcaat tactgtcaat tatgatggaa agaataagta 57121 tttgacaaaa attgaagatg gcgcgtttat cggctgcaat tccaacttgg ttgcccctgt 57181 cacagtcgga gaaggcgctt atgtggcggc aggttcaact gttacggaag atgtacctgg 57241 aaaagcactt gctattgcca gagcgagaca agtaaataaa gacgattatg tgaaaaatat 57301 tcataaaaaa taatcctaaa ttcggaggtt tatccatgtc taatcaatac ggagataaga 57361 atttaaagat tttttctttg aattcgaatc cagagcttgc aaaagaaatc gcagatatag 57421 ttggagttca attagggaaa tgttctgtca caagatttag tgacggggaa gtccaaatta 57481 atatcgaaga aagtattcgc ggatgtgatt gttacatcat ccagtctaca agtgaccccg 57541 ttaacgagca tattatggaa ctgctgatta tggtagatgc gttaaaacgc gcttctgcaa 57601 aaacgattaa cattgttatt ccttattacg gttatgcgcg tcaagacaga aaagcaagat 57661 cccgtgagcc aatcacagct aaacttttcg ctaacctgct tgaaacagcc ggtgcgactc 57721 gtgtgattgc acttgacctg catgcgccgc aaattcaagg attctttgat ataccgattg 57781 accacttaat gggtgttccg attttaggag aatattttga aggcaaaaat cttgaagata 57841 tcgtcattgt ttcaccagac catggcggtg tgacacgtgc ccgcaaactg gctgaccgac 57901 taaaagcgcc aattgcgatt atcgataaac gccgtccgcg tccaaacgtg gcggaagtca 57961 tgaatattgt aggtaacatc gaagggaaga ctgctatcct catcgatgac attattgata 58021 ctgcaggtac gattacactt gctgctaatg cgctcgttga aaacggagcg aaagaagtat 58081 atgcatgctg tacacaccct gtactatcag gccctgcggt tgaacggatt aataattcaa 58141 caattaaaga gcttgttgtg acaaacagca tcaagcttcc tgaagaaaag aaaattgaac 58201 gctttaagca gctttcagtc ggaccgcttc tggccgaagc gattattcgc gttcatgagc 58261 agcaatcagt cagctatctg ttcagctaaa ccatttttcg aggtttaaat ccttatcgtt 58321 atgggtattg tttgtaatag gacaactaaa acgacaagag gatggtgctg aatatggcaa 58381 ctttaacggc aaaagaaaga acggacttta ctcgttcgtc tcttcggaat atccgtactt 58441 caggacatgt tccaggtatc atatatggga aggatacggg taacaaacct gtgtcattag 58501 acagtgtgga gctcatcaaa acgctgaggg acgaaggcaa aaatgcagtc attacgcttg 58561 aggtcagcgg agaaaaacac tcagtcatgg taacagacct gcagacggac ccgctgaaaa 58621 atgaaatcac tcatgctgat tttcaagtag ttaatatgag tgaggacatt gaagtggaag 58681 ttccgattca tctgaccgga gaagccattg gagtgaaaaa cggaggcgta ctgcagcagc 58741 cgttatatgc acttactgta aaggccaagc caaaagccat tccgcaaacg attgaggctg 58801 atatttcaag cctcgatgta aatgaagtac tgacgattgc ggatttgcct gctggcggtg 58861 actactcctt taatcatgaa tcagatgagg ttgtggcttc aatccttcct ccgcagcagc 58921 aggaagcagc tgaggtcgat gaagaggaat ctgccgatgc tcagcctgaa ggtgaaaacg 58981 aacaataata gcttaaggcg taaccctccc gcggttacgt cttttgtgct agaatgagaa 59041 gaattatagc ccgtttatga agacgggagt tatgtgacta agggaggatt cgccatgctt 59101 gtgattgccg gtctcggaaa cccggggaag aactatgaaa atacacggca taatgtcgga 59161 tttatggtga tagatcagct tgcaaaggaa tggaatatag agctgaatca aaataaattt 59221 aacggattat acggaaccgg atttgtttcc ggcaaaaagg ttctacttgt taaaccgctt 59281 acatatatga atttatcagg agaatgtttg cggcctttaa tggactacta tgatgtcgat 59341 aacgaagatt tgacagtcat ttacgacgac cttgaccttc cgactggcaa gatccgttta 59401 agaacgaaag gaagcgccgg agggcacaat ggcatcaaat cactgatcca gcatcttgga 59461 acgtccgagt ttgaccgtat ccgcatcgga atcggccggc ctgtaaacgg catgaaggtc 59521 gttgattatg tgttaggctc ctttaccaag gaggaggcac ctgagatcga agaagcggtt 59581 gataaatctg tgaaggcttg tgaggcttct ttgagtaaac cgtttttaga agtcatgaac 59641 gaatttaacg caaaggtata aaatgtaaca acaaagtcca tactacacca aaatgacttt 59701 ttcatcagga ggacccttgt atggctttgc attattattg tcgtcattgc ggagtgaaag 59761 taggcagtct cgaatcttca atggtatcga cagactcact tggatttcag cacttaacaa 59821 atgaggaaag aaacgatatg atttcttata aagaaaatgg agatgtccat gttttgacga 59881 tatgtgaaga ctgccaagag gcgcttgacc gaaatccgca ttaccacgaa tatcacacat 59941 ttattcaata aaaagctttg gtgtagacac tagaccaaag cgtttttctg ttctcgcagg 60001 aaacagagag gaggggccat atggacaaca ttcaaacctt tataaaagaa agcgatgact 60061 ttaaatccat catcaacggt ttacacgagg gcctgaagga acagctgctc gcgggtctgt 60121 cgggttccgc gcgttctgtt tttacttctg ctctggctaa tgaaacgaat aagcctatct 60181 ttctcatcac ccataactta tatcaagccc agaaagtaac agatgatctg acttcacttc 60241 tagaggatcg gtctgtcctt ttgtaccccg tcaatgaact catttcatca gaaatcgcag 60301 ttgcaagccc tgaattgcgg gcgcagcgat tagatgtcat taatagacta acgaatggag 60361 aagcgccaat tgtcgttgct ccggtagctg caatcagaag aatgctgccg cctgttgagg 60421 tgtggaaaag cagccagatg ctcattcaag taggccatga tattgaacct gaccagcttg 60481 cctcacggct ggtagaggta gggtatgagc ggtctgatat ggtttctgcg cccggggaat 60541 tcagtattcg cgggggaatc attgacattt atccgctgac ttcagagaat ccggtgagaa 60601 ttgaactttt tgacaccgag gtggattcaa tccgcagctt taattcagat gatcagcggt 60661 caattgagac ccttacctcg atcaatatcg gtcccgcgaa ggaattaatt atcagaccgg 60721 aagaaaaagc gcgggcgatg gagaaaatcg atagtggtct tgccgcgagc ttgaaaaaat 60781 taaaggctga caaacaaaaa gaaatacttc atgcgaatat ttctcacgat aaagaacgct 60841 tgtctgaagg ccagacagat caggagctcg tgaagtatct ctcatatttc tatgaaaagc 60901 ctgctagttt actagattat acacctgata atacacttct gattttggat gaagtcagtc 60961 ggattcatga gatggaagaa cagcttcaaa aagaagaagc ggagtttata acaaatcttc 61021 ttgaggaagg gaagattttg catgacattc gtttgtcatt cagcttccaa aaaatagtgg 61081 ctgagcaaaa acggcctctg ctgtactact ctttattttt gcggcatgta caccatacga 61141 gcccgcaaaa tatcgtcaat gtgtcaggcc ggcaaatgca gagtttccat ggccaaatga 61201 acgtgcttgc gggcgaaatg gagcgtttta aaaaatcaaa tttcactgtt gtgttcttag 61261 gagcaaacaa ggaacgtacg cagaaattgt catctgtttt ggctgattat gatatcgagg 61321 ccgccatgac agacagcaaa aaagcgcttg ttcagggaca ggtctatatc atggaaggcg 61381 agctccaatc gggatttgag ctgccgttaa tgaagcttgc cgttatcacg gaagaagaac 61441 tgttcaaaaa ccgtgtaaag aagaagccgc gaaaacagaa gcttaccaat gcagagcgca 61501 tcaaaagcta ttctgagctt caaattggag attatgtcgt tcatattaat cacgggatcg 61561 gaaaatacct ggggattgaa actcttgaaa tcaacggcat tcataaagac tatttaaata 61621 tacattatca gggcagtgac aagctttacg tccctgtaga acaaattgat caggtccaaa 61681 aatatgttgg ctccgaagga aaagagccaa agctgtataa attaggcgga agtgaatgga 61741 agcgggtcaa gaaaaaagta gagacatccg ttcaggatat tgctgatgac ttaattaagc 61801 tgtatgccga aagagaagcg agcaagggct atgcgttttc tcctgaccat gagatgcagc 61861 gtgaattcga atcggctttc ccttatcaag agactgagga tcagctccgt tctattcacg 61921 aaatcaaaaa agacatggaa agagaacgtc cgatggaccg cttgctgtgc ggagatgtgg 61981 gctacggtaa aacagaggtt gccatacgtg ccgcgtttaa ggcgatcggt gacggaaagc 62041 aggtagctct gctcgttccg acaaccattt tggcacagca gcactatgaa accataaaag 62101 agcgcttcca ggactatccg attaatatcg gccttctcag caggttcaga acgagaaaag 62161 aagcaaacga aacaatcaaa gggctgaaaa atggaacggt tgatatcgtc atcgggacgc 62221 atcggctgct atcaaaggat gtcgtgtata aagacttagg gctcctcatc attgatgaag 62281 agcagcgttt cggtgtaacc cataaagaaa agatcaagca aataaaagcc aatgttgatg 62341 tattaacgtt aacagcaacg ccgattccgc gtacgctgca tatgtctatg cttggcgtaa 62401 gggacctttc agtcatcgag actccgccgg aaaatcgctt ccccgtacag acgtatgttg 62461 tggaatataa cggcgctctt gtcagagagg cgattgaacg tgagcttgca cgcggaggcc 62521 aggtctattt cttgtacaac cgggtagagg acattgagcg gaaagcggat gaaatttcaa 62581 tgctagtccc tgacgcgaag gtagcatatg cgcatgggaa aatgacagaa aatgaattag 62641 aaaccgttat gctaagcttc cttgaaggag aatcagacgt tctcgtcagc acaaccatta 62701 tcgaaactgg cgtggacatc ccaaacgtca atacgctgat cgtatttgac gccgacaaga 62761 tgggactttc tcagctttac cagctgcggg ggcgtgtcgg ccgttctaac cgtgtggcgt 62821 atgcgtactt cacgtatcgc cgggataaag tgctgacaga agtggctgaa aaaaggctgc 62881 aggctattaa agaattcaca gagttaggtt ccggttttaa aatcgcaatg cgtgacttaa 62941 cgattcgcgg agccgggaat cttcttggtg cccagcagca tggcttcatc gattcggtcg 63001 gatttgacct ctattcacaa atgctgaagg aggccattga ggagcgtaaa ggagacacag 63061 cgaagacaga gcagtttgaa acagaaattg atgtcgagct tgatgcgtat attccggaaa 63121 cttatattca agacggcaaa cagaaaattg atatgtataa acgcttcagg tctgtggcga 63181 caatcgaaga gaagaatgag cttcaagatg aaatgatcga ccgctttgga aactatccaa 63241 aagaagtcga atacttgttt actgttgcag aaatgaaagt ctatgcgaga caggaacgtg 63301 tcgagctgat taagcaggat aaagatgctg tcagattgac gatttctgaa gaagcaagtg 63361 ctgaaattga cgggcagaag ctgtttgagc ttggcaatca atatggcaga caaatcggac 63421 tgggaatgga agggaaaaaa ctcaaaatct ccatacagac gaaaggccgt agtgctgatg 63481 aatggctcga caccgtgctg ggcatgctga agggcttaaa agatgtgaaa aagcaaacca 63541 tttcatcaac gtaaattttg ttactctctg gtgtatatta catttgatgt gacggatact 63601 aatttcaagc gaggcggaag gtacataaag taactgcttt aggtctttcc cacatgtata 63661 taccatcaaa tgaaagagag gcaccagaga tgaaagcaac cggtatcgta cgtcgtattg 63721 atgacttagg tcgggtcgtg attcctaaag aaattcgaag aactctgaga atcagggaag 63781 gcgatccgct tgagattttt gtagatcgtg acggagaagt gattttgaaa aagtactctc 63841 cgatcagtga gcttggagac tttgcaaagg agtatgcaga cgcgctttac gacagcctcg 63901 gccattcagt gctgatttgt gatcgtgatg tatatattgc cgtgtccggc agctccaaaa 63961 aagattactt aaacaagtca atcagcgaaa tgctggaaag aacaatggat cagcgcagct 64021 ccgtgcttga gagtgatgcg aaatcagtac agcttgtgaa tggaattgat gaggacatga 64081 attcttatac tgtaggccca attgtggcga acggtgatcc gataggtgct gtggtgatct 64141 tttcaaaaga tcagacaatg ggcgaagtag agcataaagc cgttgaaaca gcagctggat 64201 ttttggctcg tcaaatggaa cagtaggtct tattcctttc ttcgaaaata ggtatgtaaa 64261 gaacagctct ccttgggacg ctgttctttt tcatgcgtgc cgaaaaagga atccaagggt 64321 tgggatgtgg tataataacc tcgtttttat ttgtgccgcg gtaatacgtg aaccgtattg 64381 cccctgacgt tgggaaggag cttttggatg gacgattcaa taggcgttaa acggcattgg 64441 atttggcagg gggcttttgt tttaattctg gcaggcgtca tcacaaaaat tttaagcgct 64501 gtttacagag tcccgtttca aaacattgtc ggcgatgttg gattttatat atatcagcag 64561 gtatacccct ttcttggtat tgcggtcatg ctgtccacat caggatttcc agtcattatt 64621 tcaaagctga tgaatgatta tagtgaaaaa aatcatcaca ccatattaaa aatatcagcg 64681 ttgtttttgt ctttaatcgg tattttatta tttctttgtt tatatctggg tgctgttcct 64741 attgcactct ttatgggaga ttcgcatcta gccgtgttaa ttcaagtggc cgcatacgcg 64801 tttctgcttt tcccatttgt cgcgttgcta agaggcggtt ttcaggggcg gcacgaaatg 64861 ctcccttcag ccttatcaca gatgacagag cagtttctgc gtgttgcggt gctcttgggt 64921 ttatcatttt ggctcgtgaa aaagggagcc tcgctttata ctgcgggagc ggcagccgct 64981 tcaggctctc ttgccggaag tttggttgca ttgataatac tggggttttt ttggttcaaa 65041 acgaaaagag acaaccaaac ggataggcaa aacgaaaatg tcatcacaac aaaagaattg 65101 acgaaaaaac tgcttttata ttcggtcaca atttgtgtaa gcagtttgct gcttttgttt 65161 atccagcttg ttgatgcttt gaatttatat gcattgcttt cgggtggtga ggcaagcgaa 65221 gaagcaaaat gcctaaaggg gatctatgat cggggacaac ccttgttgca gctcggttca 65281 gtttttgccg taagcattgc gacgtcactc gttccgtata tttctatggc tgtaaaaaac 65341 aaagagctga agatcatgaa agaaaaaatc acgtcatctt tgaaactatg ccttgtgctc 65401 ggtacaggcg catcggctgg gttgatttgc attctaaagc cggtaaatat catgctgttt 65461 caaaatggag aagggacagg tgcgttacaa gtatttagct gctccatttt gtttgcatcc 65521 ttggcggtaa cggcagcggc agtcttacag ggagcgggat acacagtttt tcctgcgata 65581 gcggtgggcg cgggtgttgc ggtgaaatgg gtgttaaaca cacttttggt tccgcgctat 65641 gggattgaag gcgcatcgct tgcgacagcg gcttcctttg cggctgtcgc cggccttaac 65701 ttgtatcagc ttcggcaaaa ggaatggctc gataagctta gaggcgtttt gattccgatt 65761 attggatctg ctcttttgat gtcagctgtt ttgcttgcgt atacgcgtct ctggactttc 65821 ttgtttcctg caacaggaag aggagcggct gtgattgaga gtctttctgc tgttgccatt 65881 ggtggcgcgg tgtttattta ttgtatgatg agattgggaa tatttacaga tgaagagctg 65941 aacagtgtgc cattcggcag caagttaagc aaattcatga gaaggagaga acaaaatggc 66001 gggtaaaatt acagtcgtcg gacttggtgc cggagacatg gaccaattga caattggtat 66061 acacaagctg ctgacgaagg cagatacgct gtatgtcaga accaaggatc atcctttaat 66121 tgaggagctt gaaaaagaaa cgaagaacat ccgtttcttt gatgatatat atgagaaaca 66181 tgatcagttc gaggcggtat atgaagaaat tgcagatatc ctctttgaag cggcgcggcg 66241 tgaggacgtg gtttacgctg tgccgggaca cccttttgtc gcagaaaaaa cagttcagct 66301 gctgacggag cggcaggaaa aggaaaacgt tcaagtgaaa gtcgcggggg gacaaagttt 66361 ccttgatgcc acattcaatg tcttgcaaat tgacccgatt gaaggttttc aatttgtgga 66421 tgccggcaca ttgtccgcgg atgagcttga gctcagacat catctgatca tatgtcaggt 66481 ttacgaccaa atgacggctt ctgaagtcaa gctgacattg atggagaagc tgcctgatga 66541 ttatgaggtc gtcattgtga ctgcagcagg cagccgtggc gaggagatca ggacagtgcc 66601 attatttgag ctggaccgca atgtcgcttt gaacaactta acaagtgtgt atattccgcc 66661 gattaaagaa gagaagctgc tttatcacga attctccacg ttccgaagca tcatcagaga 66721 gcttcgcgga cctaatggat gtccgtggga taaaaagcag acgcatcagt cattaaagca 66781 gtacatgatt gaagaatgtt atgagcttct cgaagctatt gacgaagaag acacagacca 66841 tatgatcgaa gagcttggcg acgttttgct tcaggtcttg cttcacgcgc aaattggtga 66901 agatgaaggt tatttcacaa ttgatgatgt cataaaagga atcagtgaaa aaatggtccg 66961 aagacatccc catgtgttta aagatgttaa ggttcaggat gaaaacgatg ttttagccaa 67021 ttgggaagat ataaaaaagg ccgaaaaaaa tacatctgaa tcatcattac tagacagcgt 67081 accgaaaacc cttccagctc tttcgaaagc agctaaattg cagaaaaaag cagcgaaggt 67141 cggttttgac tgggaagacg tcagcgatat ttgggaaaag gtaagtgagg aaatgaagga 67201 attttcttct gaggtttctg aagctcctca cgaacacaat cttaaagctg agtttggcga 67261 cattttgttc gcgctggtga atgtagcccg cttctacaaa atagagccag aggaagcgct 67321 gaccatgact aatgacaaat tccggagacg gttctcgtac attgaggaaa cagcgaagga 67381 agagggagtc gagttggctg atatgtccct tgaggacatg gacaaactgt ggaatgaagc 67441 aaaagaaact gagaggagat catagatatg agattagata aatttttgaa agtatcacgg 67501 ctgatcaaac ggcgtacact agcgaaggaa gtagctgacc aaggacgaat ctctattaac 67561 ggaaaccaag ctaaagctag ctctgacgta aaaccgggag atgaactaac ggtccgcttc 67621 ggccaaaagc ttgtaacggt tcaagttaat gaattgaaag acacgacgaa aaaagaagaa 67681 gctgcaaaca tgtacacgat tctaaaagaa gaaaaactcg gcgaataggc ttgttctaaa 67741 aaaacccccc acctcataca atgcagtaat aatgctaaaa gtatcgagga tatgggggct 67801 gaatagatga attcatatta tgatcaaaaa ggttcttcgt ctgttccgga acagcatgat 67861 gtgacaatga aaggccggaa gcatttagat atttctgggg ttaagcatgt ggagagtttt 67921 gataacgaag aattcctgct ggaaacggtg atgggaatgc tctccgtcag aggccaaaac 67981 ctgcagatga aaaatcttga tgtggaaaaa gggattgttt cgattaaagg cagggtattt 68041 gatttagtgt acttagacga acaacaaggg gataaagcta aagggttttt tagcaagttg 68101 tttaaatgac gctgacgaca caattctata caatgctagc gatgtccggt atgggtctct 68161 ggcttggtgc ttcgcttgat acataccggc tctttgtcat tcgtgccaaa acagccagat 68221 ggctattatt tattcatgat attcttttct ggattatgca agggctgctt ttcttttatg 68281 tcttgcttca tgtaaatgag ggagaattca ggatttacat ctttttagcg gttctgctgg 68341 gcgttgcgac gtatcagagc ctttgcaaac gaatctatat aaaaatactg aaattcgtca 68401 tttaccttgt tgtttctgtt tatcaattct tcaaaaaact cattcagcac gtgttatttc 68461 gtcctattgt gtggacatgc ggagcgatca tctggctggc ggcattttta ttcaagaaaa 68521 catacagcct gataggtttt ctcctgctgt gtctatataa aatagtcatg gttctgtgtt 68581 ttccgatccg ttttatcgcg aaacaatgtt tgaaacttct tcctgtgaaa atgcgtctaa 68641 cttttagacg ttattttgaa aaaggtgcag gatttctcaa aaagaagaag aaactattga 68701 taaccataag aacgaccatc acacggtttt tgaagagatg aaaggaggac cgtctggttt 68761 gaatttttcc agggaacgaa cgataactga aatacaaaac gactataaag aacaagtaga 68821 acggcaaaat cagctgaaga aacgaagacg caaagggctg tacagacggt taactgtatt 68881 cggcgcccta gtattcctga cggcaattgt gctggcaagc tctgtatggt cccaaacatc 68941 ttcccttagt gcaaaagaag aaaagaaaga acagcttgaa aaagaactga aaagtttaaa 69001 gacaaaacaa acggatttaa aagaagaaat atccaaattg aaggatgagg attacgtcac 69061 agagcttgcc agaagggact tattcatgtc tggagacgga gaaattatct tcaatgtgga 69121 gaagaagagc aagtagcctt gttgacactt aaatttttat ttaggtataa ttaagcaaac 69181 gatcttttta taagcctaag gaggagcact ttttttatgt cgattgaagt tggcagcaag 69241 ttgcaaggga aaattacagg tattacaaat tttggagcat ttgttgaatt gcctggaggc 69301 tcaaccggtc tcgttcacat tagtgaggta gctgataatt atgtcaaaga cattaacgac 69361 cacttaaaag tcggcgacca agttgaagtg aaagtcatca acgttgaaaa agacgggaaa 69421 attggtttat ctattaaaaa agctaaagac cgtccgcaag ccagacctag aaatgatttc 69481 cgtccgaaag aatcttttga acagaaaatg aataagtttt taaaagacag cgaagatcgc 69541 ttgtcatctt taaaacgcaa tacggaatca aaacgtggag ggcgcggagc aagaagagga 69601 taacttgctg ctttctataa aataaatgaa gcatccgttc atcccgacgg atgctttttt 69661 attatcctca ttctctttaa gagtcagaaa attacaacat taaagtttct gttgacgaaa 69721 gagacaaacc tttgtattat ataacttgtg cttagaagca caaaacaata tggcggtgta 69781 gctcagctgg ctagagcgta cggttcatac ccgtgaggtc gggggttcga tcccctccgc 69841 cgctaccata tttgtttggc ccgttggtca agcggttaag acaccgccct ttcacggcgg 69901 taacacgggt tcgaatcccg tacgggtcat cctaacaaat cggtttctct tgcagaagcc 69961 gatttttttc atttttagac aacattccgg aaattctttt cataaacgaa tatcaaggca 70021 gaaaccgtcg aagatttctt tggtattgtt accttctttt gacaaaatcc tatctgtgct 70081 ttcgctataa tgacaggcaa cgaatataac aggtgggaga tgagaggaat ggaaaaagca 70141 gaaagaagag tgaacgggcc aatggcggga caagctttgg aaaaactcca atcgtttttt 70201 aacaggggca cgaagctggt gactcatcat ttgcattcac tgtttttcta taaaggattc 70261 atttatgttg tcatcggatt tttgcttgga cgggctttca tattatccga ggtgcttcct 70321 ttcgcacttc ctttctttgg agcgatgctt cttatcagaa gagacaaagc gttttatgcg 70381 gttttggctg tgcttgcagg tgcgctgacc atatctccaa agcactcatt gctcatactg 70441 gcggcattgc tggcattctt cgtattttct aaagtggctg ccttcattac cgacgatcgt 70501 gttaaagcgc tcccgattgt cgtgttcttc tccatggctg cagcaagagc cgggtttgtt 70561 tatgcccaaa atggcgtatt tacaacctat gattatgtaa tggctatcgt tgaggctgga 70621 ctatcgttta tcttaacact gattttcctt cagagccttc cgatttttac tgtgaaaaaa 70681 gtgaaacaat cattaaaaat agaggaaatc atttgcttta tgattcttat tgcctctgtt 70741 ttaacggggc tggctggctt gtcctaccaa gggatgcagg cagaacatat attggctcgt 70801 tatgttgtgt tgagtttttc ctttattggc ggagcaagca tcggctgtac ggttggggtt 70861 gtgaccggcc tgattcttgg cttggcgaat atcggaaacc tatatcaaat gagtctgctt 70921 gctttttccg gtttattggg cggtttgctg aaggaaggga aaaaagcggg tgcagcaatt 70981 ggtttgatcg ttggatcact tcttatatct ttatatggtg aaggctctgc cggtctgatg 71041 acaacgctct atgagtcatt aatcgcagtc tgcctgtttt tgctcacacc tcaatctatt 71101 acgaggaaag tggcgagata tattccggga actgtcgagc atcttcaaga gcaacagcaa 71161 tacgctagaa aaatccgtga tgtcactgct cagaaggtag accaattctc caatgtattt 71221 cacgcgctgt ctgaaagctt tgcaaccttt tatcaagcat cagacgaaca gacagatgac 71281 agcgaagttg atctgttctt aagcaaaatc acggagcatt cctgccagac gtgctacaag 71341 aaaaacaggt gctgggtaca gaactttgat aaaacatatg acttaatgaa acaagttatg 71401 cttgaaacag aggaaaaaga atatgcatca aaccgaaggc tgaaaaaaga gtttcaacag 71461 tattgttcta aatccaagca ggttgaagag ctgattgagg atgagctcgc acatcatcat 71521 gcccatttga cactcaagaa aaaagtccaa gacagcaggc gccttgttgc tgaacagctt 71581 ttaggcgttt ctgaggttat ggccgacttt tctcgggaaa taaaaagaga gcgagaacaa 71641 cactttctgc aggaagagca aatcatagaa gcgcttcagc atttcggaat tgagattcag 71701 catgtcgaga tctatagtct tgaacaagga aatatcgata ttgaaatgac cattccgttc 71761 agcggacatg gagaaagtga aaaaatcatt gctcctatgc tttctgacat tctggaggaa 71821 caaattcttg tgaaagccga acagcactct ccgcatccga atggatacag ccatgtcgcc 71881 tttggatcaa caaaatcata cagggtgtcc acgggagctg ctcacgctgc gaagggcggc 71941 ggccttgtct ccggtgacag ctacagcatg atggagcttg gagccagaaa atatgctgca 72001 gcaatcagtg acggaatggg caatggcgca agagcgcact ttgaaagcaa tgaaacgatc 72061 aagcttcttg aaaaaatcct tgaatcgggc attgatgaaa aaatagcaat taaaacgatc 72121 aacagcatac tgtctctaag gacaactgac gaaatatatt ccacgcttga cctatctatt 72181 atcgatcttc aagatgccag ctgtaaattt ttgaaggttg gatcgacgcc cagctttatc 72241 aaacggggtg accaggtcat gaaagttcaa gcgagcaatc tgccaatcgg tattattaat 72301 gaattcgatg tggaggttgt gagtgaacag ctgaaagcgg gtgacctctt aattatgatg 72361 agtgatggca tttttgaggg gcctaagcat gtggaaaatc acgacttatg gatgaagcgt 72421 aaaatgaaag ggttgaaaac aaatgacccg caggagattg ccgatttgct tatggaagaa 72481 gtcatccgca caagatccgg ccaaattgag gacgatatga ctgttgttgt cgtccggatt 72541 gatcacaata caccgaagtg ggcatccatt cctgttccgg caatctttca aaacaaacaa 72601 gaaatttcat aacgcttccg tataaatcaa atttcttctg gcgaagatgg gaatatatga 72661 atctgagaat cctcgtattc tccaggagga atgaatgtga acaacggaca tttaaatcaa 72721 attttgctga taacggatgg ctgctcaaac catggggaag acccgcttgc aatggctgct 72781 tttgctaaag agcaggggat tacggtaaat gtcattggta taatggaaga aaatcaaatt 72841 gaccctgagg caatgaagga agtcgaaggg attgcacttg ccggaggagg cgtgcaccaa 72901 gtcgtttatg catctcagct ttcacaaact gttcaaatgg taacaaagaa agcgatgacg 72961 caaaccttac aaggtgtagt caatcaagaa ctgaaacaga ttctcggaaa gaatgtggaa 73021 atggaagagc tttctccgga aaaacgcggc gaagtcatgg aagtggtaga cgagcttgga 73081 gaaacggtgc atcttcaggt tttggttctt gttgatacaa gtgcaagtat ggcgccaaag 73141 cttccaacag taaaagaggc gctgattgat ttgtctgtaa gcctcaattc ccgaattggg 73201 aataacgaat ttgcgatgtg tatatttccc gggaaaaaac aagaggtcga gcttgtgctg 73261 aactggacac cgaagctgca atctctttcc acactctttg caaagctttc gacaggcggc 73321 atcacgccga caggtccggc gattcgtgaa gcgacactgc agtttgaaaa aatacgctca 73381 agaaggggca tgctggcaga tgatgaacga cgctttgacg agtttggcat gtagcctcaa 73441 gccgggtacg acaatcaaag gcaagtggaa tggaaacact tatacattgc gtaaacagct 73501 tggtaaaggg gccaatggaa ttgtgtattt ggcagaaaca tcagatggac atgttgcctt 73561 aaaggtgagt gatgacagcc tgtctattac ttctgaagtg aatgtcttga aatctttctc 73621 aaaggcccag tccgttacga tggggccttc tttttttgat acggatgatg cctatattcc 73681 cagtgccaat acgaaagttt cattttatgc aatggaatac ataaaagggc cgctgctttt 73741 gaagtatgtc agtgataaag gagcagagtg gataccggta ttaatgattc agctgttatc 73801 cagcttatcg gtgcttcacc agcaaggatg gatattcggc gatcttaaac ctgataatct 73861 gatcgtaact ggtccgcccg caaggatccg ctgcattgat gtgggcggca cgacaaagga 73921 aggccgggcg ataaaagagt atacggagtt ttatgacaga ggctattggg ggtatggaac 73981 aagaaaggca gagccatcct atgatctgtt cgcagttgcc atgattatga tcaacagtgt 74041 gcataaaaaa gaatttaaga aaacgaacca gcccaaagaa cagcttaggt ctctcatcga 74101 aggaaacccg ctgcttcaaa agtataaaaa agcgcttttt tcagccttga acggagatta 74161 tcaatccgca gatgaaatga aaaaggatat gctagacgcg gggcaaaaag cagcacaaag 74221 aaaacagcct ataaaagcat caccgcagcc tgccacacga caaagacagc aaaaaccgcg 74281 ccaaggaaaa ataacgaaga cgcgatatac cccaaaacag aaaccggcta agtcgggggg 74341 gttatttgaa acaacgctta tcgtgatcag tgttttagcg ctttatttcg cctatattat 74401 ctttttctta atctgaatgg tgcaaactgc agagcctatg cttcttcttt gcttggaggg 74461 gttgaaagtg ttaggatatg aatatcttta aaatacctgc tcattgtgag gaggacattg 74521 tgaaaagtgt caaagatttt ttaaacaaac acaatcttac gttaaaaggg gcgacaatca 74581 ttgtaggcgt ttccggcggt ccggactcaa tggctcttct tcacgcgttg catacgttat 74641 gcggccgttc agcgaatgtt attgcagctc acgttgacca tcggttcaga ggtgcggaat 74701 ccgaggagga catgcgtttt gtccaagctt attgtaaagc tgaacagctc gtgtgcgaaa 74761 cggctcaaat caatgtaacc gcatatgcac aggaaaaagg actcaataag caggctgcag 74821 cacgcgattg ccgctaccag ttttttgagg aaatcatgtc gaagcaccaa gcggactatc 74881 tggctcttgc gcatcatggt gatgaccagg ttgaaacaat gcttatgaaa ctggctaagg 74941 gtacgcttgg aacgggactt gcgggaatgc agccggttag acgttttggg acagggcgga 75001 tcatcaggcc gttcttaacc attacaaagg aagagatcct tcactattgc catgaaaacg 75061 gcttgagcta ccggacggat gaaagcaacg ccaaagatga ctacacaaga aacagattca 75121 gaaaaacagt gctcccgttt ttgaagcagg aatctccgga tgtgcataaa aggtttcaga 75181 aagtgagtga agcactgacg gaagatgagc aattcttaca gtcattaacg aaagatgaaa 75241 tgaataaagt aatcacaagc cagtctaata catcagttga aatcaattcc tctcaattgc 75301 ttgccctccc gatgccttta caaagaagag gagttcaact aatattaaac tatctttatg 75361 aaaacgttcc atcatccttt tcagcccatc acattcagca gtttctcgat tgggcggaaa 75421 atggcggtcc ttcaggagta ctggactttc cgaaagggct gaaggtggtc aaatcatatc 75481 agacatgttt gtttacattt gaacaatggc agtgcaaaaa tgttcccttt gaataccaaa 75541 ttagcggagc tgctgatgaa acggcagtgc tccctaatgg atatctgata gaggcaaggc 75601 attatgcgga ctcgcctgaa gaacatggga atgctgtttt tatcacaagt gaaaaaaagg 75661 tgcgatttcc cttaacaatc cggacgagaa aagctggaga ccggatcaaa ctaaaaggga 75721 tgaacggctc aaaaaaggta aaggatatat ttattgataa gaaattgcct ctccaagaaa 75781 gagacaactg gccgattgtg acggacgcaa gcggtgaaat tatctggata cctggcttga 75841 aaaaatcaat ttttgaagat cttgtgattc caaacagcga ccgcattgta ttacaatata 75901 gacagcatga aaagtgtagg gggcaagcaa aatcatgatg aaacatgata tcgagaaagt 75961 actgatctca gaggaagaga tacaaaagaa agtaaaagag ttaggtgcag aattaacgag 76021 cgagtatcaa gatacatttc cgttggcaat cggtgtgtta aaaggagcac ttccttttat 76081 ggcggatctt atcaagcata ttgatacata tttggaaatg gatttcatgg atgtatcaag 76141 ctacggaaat tctacggttt cttctggaga agtaaaaatc attaaagatt tggatacatc 76201 tgtagagggc cgggacatct taattattga agatatcatc gacagtgggt taaccttaag 76261 ttatctcgta gagctcttcc gataccgtaa agcaaaatca attaagattg ttaccctttt 76321 ggataaaccg agcggaagaa aagcggacat caaagcagac tttgtcggtt ttgaagttcc 76381 tgacgcgttt gtagtgggtt acggacttga ttatgctgag cgctatcgca atctgcctta 76441 tatcggagtg ttaaaaccgg cagtttatga aagctgatcg gcagcctgct tccgagatgg 76501 ttattgtttg tattggaatg attttctatg gtactattga acatagttgt gcttactgtg 76561 ggaggaggta aggaatgaat cgggtcttcc gtaataccat tttttattta cttattttat 76621 tagtagtaat cggggttgtg agctacttcc agacctcaaa tccgaaaaca gaaaatatgt 76681 cgtacagtac gttcatcaaa aacctggatg acgggaaagt tgatagcgta tcggttcagc 76741 ctgtcagagg tgtttatgag gtaaaagggc agctgaaaaa ctacgacaaa gatcaatact 76801 ttttgactca tgttcctgaa ggaaagggag cagaccagat atttaacgct ttgaaaaaga 76861 cagacgtaaa ggttgagccc gcgcaagaaa caagcggatg ggtgacgttc ctgacgacca 76921 tcatcccatt tgtcattatc tttattctgt ttttcttcct gctcaatcag gctcaaggcg 76981 gcggcagccg tgtcatgaac tttggcaaga gtaaagcgaa gctgtataca gaggaaaaga 77041 aacgcgtcaa atttaaagac gttgcagggg ctgacgaaga aaagcaagaa cttgttgaag 77101 ttgttgagtt tctgaaagat ccccgcaagt ttgccgagct cggcgccaga ataccgaaag 77161 gcgtgctttt agtcggacct ccgggtaccg gtaaaacatt gcttgccaag gcttgtgcag 77221 gagaagccgg cgtacctttc ttcagcatca gcggatctga tttcgttgaa atgtttgtag 77281 gggtcggtgc ttcccgtgtg cgtgacttgt ttgaaaatgc gaaaaagaat gcgccttgtt 77341 tgatcttcat tgatgaaatt gacgcagtcg gacgccagcg tggcgctggt ctcggcggtg 77401 gacacgatga acgtgaacag acgctaaacc aattgcttgt tgaaatggac ggattcagcg 77461 ctaatgaagg aattatcatc attgctgcga cgaaccgtgc ggacatcttg gacccagcct 77521 tacttcgtcc gggacgtttt gaccgtcaaa tcacagtgga ccgcccagat gtcattggcc 77581 gtgaagctgt attgaaagtc catgcgagaa acaaaccgct ggatgaaacg gttaacctaa 77641 aatcaattgc catgagaaca ccaggcttct caggcgctga cttagaaaac ctcttgaatg 77701 aagctgcgct tgtagcggct cgtcaaaaca agaaaaaaat cgatgcgcgt gatattgacg 77761 aagcgacgga ccgtgtaatt gccggacccg ctaagaagag ccgcgttatc tccaagaaag 77821 aacgcaatat cgtggcttat cacgaaggcg gacacaccgt tatcggtctc gttttagatg 77881 aggcagatat ggttcataaa gtaacgattg ttcctcgggg ccaggctggc ggttatgctg 77941 ttatgctgcc aagagaagac cgttatttcc aaacaaagcc ggagctgctt gataaaattg 78001 tcggcctctt gggcggacgt gttgctgaag agattatctt cggtgaagtc agcacagggg 78061 cgcacaatga cttccagcgt gcgacgaata ttgcaagacg aatggttaca gaattcggta 78121 tgtcagaaaa actgggaccg ttgcaatttg gacagtctca gggcggtcag gtattcttag 78181 gccgtgattt caacaacgaa cagaactaca gtgatcaaat cgcttacgaa attgatcagg 78241 aaattcagcg catcatcaaa gaatgttatg agcgtgcgaa acaaatcctg actgaaaatc 78301 gtgacaagct tgaattgatt gcccaaacgc ttctgaaagt tgaaacgctt gacgctgaac 78361 aaatcaaaca ccttatcgat catggaacat tacctgagcg taatttctca gatgatgaaa 78421 agaacgatga tgtgaaagta aacattctga caaaaacaga agaaaagaaa gacgatacga 78481 aagagtaatt cgctttcttt ctaaaaaaac tgccggctga cgctggcagt ttttttatgt 78541 aaatgattgg ctcagctgcg gcttttacaa tcatccaatt ctggtatcga tttgtttaca 78601 aatgagccgc tgatcgtgta tggtattgta gaatgtttgt aaaaagtaaa gtagagaaac 78661 tattcaaaag tggtgataga ggttgttact ggttatcgat gtggggaaca ccaatactgt 78721 acttggtgta tatcatgatg gaaaattaga atatcactgg cgtatagaaa caagcaggca 78781 taaaacagaa gatgagtttg ggatgatttt gcgctcctta tttgatcact ccgggcttat 78841 gtttgaacag atagatggca ttattatttc gtcagtagtg ccgccaatca tgtttgcgtt 78901 agaaagaatg tgcacaaaat actttcatat cgagcctcaa attgttggtc caggtatgaa 78961 aaccggttta aatataaaat atgacaatcc gaaagaagta ggggcagaca gaatcgtaaa 79021 tgctgtcgct gcgatacact tgtacggcaa tccattaatt gttgtcgatt tcggaaccgc 79081 cacaacgtac tgctatattg atgaaaacaa acaatacatg ggcggggcga ttgcccctgg 79141 gattacaatt tcgacagagg cgctttactc gcgtgcagca aagcttcctc gtatcgaaat 79201 cacccggccc gacaatatta tcggaaaaaa cactgttagc gcgatgcaat ctggaatttt 79261 atttggctat gtcggccaag tggaaggaat cgttaagcga atgaaatggc aggcaaaaca 79321 ggaaccaaag gtcattgcga caggaggcct ggcgccgctc attgcgaacg aatcagattg 79381 tatagacatc gttgatccat tcttaaccct aaaagggctg gaattgattt atgaaagaaa 79441 ccgcgtagga agtgtatagg aggtttagta atggattatt tagtaaaagc acttgcgtat 79501 gacggaaaag ttcgggctta tgcagcgaga acgactgata tggtaaatga ggggcagaga 79561 cgccatggta cgtggccgac agcatccgct gcactaggcc gtacaatgac agcttcactt 79621 atgctcggcg ctatgctgaa gggcgatgat aagctgaccg tgaaaatcga gggcggaggt 79681 ccgatcggag ctattgtagc tgatgccaat gccaaaggag aagtcagagc ctatgtctct 79741 aacccgcaag ttcattttga tttaaatgaa caaggtaagc ttgatgtcag acgtgcggtt 79801 ggaacaaacg gaacgttaag tgtcgtaaaa gatttaggtt tgcgcgagtt cttcacagga 79861 caagtagaaa tcgtttcagg agaattagga gatgatttta cttactatct tgtgtcatct 79921 gagcaggttc cttcatcagt gggcgtaggt gtgctcgtaa atcctgacaa taccattctt 79981 gcggcagggg gctttattat tcagctgatg ccgggaacag atgatgaaac aatcacaaaa 80041 attgaacagc gtctatctca agtagagccg atttctaagc tcatccaaaa agggctgaca 80101 ccagaagaaa ttttagaaga agtcctaggc gagaaacctg agattttgga aacgatgcct 80161 gtcagattcc attgcccttg ttcaaaagaa cggttcgaaa cagccatttt aggactaggc 80221 aaaaaagaaa ttcaagatat gatagaagaa gatggacaag ccgaagcagt atgccatttt 80281 tgtaatgaaa agtacttatt tacaaaagaa gagctggaag ggcttcgtga ccaaactacc 80341 cgctaagctc tttagcgggt ttttaatttg agaaaagggg ctgaaagcag gtttgaaatc 80401 aagaacaatc tggaccatta ttttaggggc gctgttggtt tgctgtattg ctgttgcata 80461 tacgctgacg aaatcccaag ccggcgcatc gtcatccggt gagtctattg cgactatcgg 80521 aggcaagagt gtgacaagag aagaatggct gaaagaaatg gaagatcagt atggtaagtc 80581 aacgcttgaa gatatgatca atgtccgagt tgttgagcag ctggctaaaa agaacaaact 80641 taaaatatcc aaaagcgaag ttgatcgtga gtttttgctg attaaagcgg tcaataattc 80701 cttttacgaa gatgaacata cgacggagaa agagtggaaa gaccaaattc gttataatat 80761 cctccttgag gatttgttaa caagggatat cgatatctca aacaaagaat tggaatcatt 80821 ctataataaa aataaggaac tatatcagtt tgatgattcg tatcgaattc ggcacattgt 80881 tgtaaaagat gaagaagaag caagagaagt cctgaaagaa ctgaaaggcg gatcaagctt 80941 tgaagctgtc gctgccgaaa gatctacaga cagatataca tcaccatacg gcggagattt 81001 aggttttgtc acagaggcat cagacaacat tccatcagca tacattgaag aggcgaaaac 81061 actcaaagag gatgaatggt ctcaggaacc aataaaggtc agcaacggat atgccattat 81121 ccagctgaaa gaaaaactaa aggcaagaac gttctcattt gatgaagtaa aggaccagat 81181 cagacggcaa atcgcaatgg atcagctagg cgataaagcg acagttaaga cactttggaa 81241 agaagccgat gtatcttggt tttatgggga aaaaagtact aagtgattga caaaaaattt 81301 tgaaattgat agattatata cataatacca atacaaatag tcggaaattg aggtgtcgag 81361 aatggtacgt gtagcaaact ccattactga attaattggg aatacgccaa tcgttaaatt 81421 aaatcgcctt gcagatgaaa acagtgcgga tgtatatcta aaacttgaat acatgaaccc 81481 tggaagcagt gtaaaagacc gtatcggttt agctatgatt gaagcggctg aaaaagaagg 81541 aaaattaaaa gccggtaata caatcattga accgacaagc ggaaatactg gaatcgggct 81601 tgcaatggtt gctgctgcta aaggattaaa agccattttg gttatgcctg atacaatgag 81661 catggagcgc cgcaaccttc ttcgcgcata tggtgctgag cttgtgctga ctcctggtgc 81721 ggaaggcatg aaaggtgcta ttaagaaagc tgaagagctt gctgaaaagc acggatactt 81781 tgtgccgcag cagtttaaca acccttctaa ccccgaaatt caccgccaaa caacgggtaa 81841 agaaatcgtt gagcaattcg gtgatgatca gcttgacgca tttgtagccg gaatcggaac 81901 gggcggaacg attacgggag cgggcgaagt gctgaaggaa gcataccctt ccatcaagat 81961 ttatgctgtt gaaccgtcag attccccagt gctttcagga ggaaaaccag gcccccacaa 82021 aattcaggga atcggagcag gattcgtgcc ggacatctta aacactgaag tatatgatga 82081 aatcttccct gtgaagaatg aagaagcatt cgaatatgcc cgcagagctg cacgtgaaga 82141 aggaattctc ggaggcatct catcaggtgc ggcaatttat gctgctcttc aagtagcaaa 82201 aaaactcgga aaaggcaaaa aagtattggc catcattcca agtaacggcg aacgttatct 82261 aagcacgccg ctgtaccaat tcgattaaaa aaagccaaaa ctcccggttc gccgggagtt 82321 tttttatatt tcgtgcatca aatatgccat gtctgcgacg aatgttattc ttggaagaga 82381 aattcacttt tttcactaac aacattgctt tacaattaaa aacaagtaaa aaagaaaata 82441 gaggaatgat acaaatggca caacgcagac cggcaggcaa aaaaatacct tttcaaaaag 82501 actcattctt acaacaattt gagaaacttg cgcaatcccg gaaacatcat gtacttctcg 82561 aaagtgcaag aggcggcaga tatagtatag ccggtcttga tccaattgcg actgtgaaag 82621 gaaaagacgg aataactaca attaagcatg gtgatgagat gctgtttaaa gaaggtgatc 82681 cattacgggc cttccacagc tggtttaaaa cactggaaac agaaacgaat catgagttcc 82741 ctgactttca aggcggggca atcgggtttc tcagctatga ttacgcacgg tacattgaaa 82801 attttaaaat gctctcatta gatgatttag aaacaccaga tatttatttt cttgtttttg 82861 atgatatagc agtttatgac catcaagaag agtctctatg gctgattact catgttaatg 82921 gttctgatca ggaaacagcg gatgtgaagc tatctgagtt agagcagatg tggttgactg 82981 agcttcccgc tgtcacttcg cgagagatga agcctgaaac agctggttct ttcgcggcgc 83041 catttaccga ggatgggttc tcacaagctg tagagaaaat caaacaatac attgccagcg 83101 gagatgtgtt tcaagtcaat ctatcaataa ggcagtcaca gtcactgtct gtccacccat 83161 atcaaattta caaaaccttg agagaagtaa atccttctcc ttatatggcg tatttagaaa 83221 cacctgattt ccaaatcatt tgcggatcgc ctgaactgct tgtcagcaaa aagggcaagc 83281 tattagagac gagaccgatt gcgggcaccc gttccagagg gaaaacaaat gaagaagacg 83341 aggcgcttgc aaacgaattg atacacaatg aaaaagaacg cgcggaacat gtcatgctgg 83401 ttgatcttga gcgaaatgat ctgggaagag tatcacgtta cgggtctgtg cgcgtaaatg 83461 aattcatggc aattgaaaaa tactcgcatg tgatgcacat tgtgtctaat gtccaaggtg 83521 aactgcagga tgggtatgat gctgtagata ttattcatgc tgtgtttccc ggaggaacca 83581 ttactggtgc accgaaagta agaacgatgg aaattataga agaacttgag ccgacacgcc 83641 gagggcttta tactggatct ataggatggt ttggatataa tcacgatctg cagtttaata 83701 tcgtcattcg aaccatttat gcaaccggag ggcaggcatt tatgcagtcc ggtgcaggag 83761 ttgtgattga ttctgttccg aagcacgaat acaaggaatc attcaaaaaa gcttttgcga 83821 tgcaaagagc attagagctg agcgaagaag agacaaaaat tagatgaggt gagcggagaa 83881 atgattttaa tgattgataa ctacgattca ttcacgtaca acttggtaca gtatttgggc 83941 gagcttgggg aagagctggt tgtgaaacgc aatgacagca tcacaatcga tgaaattgaa 84001 gaactgtctc cggactttct gatgatatct cccggaccgt gcagccctga tgaggcggga 84061 atcagcctcg aagcaattaa acatttcgca gggaaaattc ctattttcgg tgtatgtctc 84121 ggacatcagt ccatcgcaca agtgttcggt ggtgatgttg ttagggcaga acggcttatg 84181 cacgggaaaa cctcggatat cgagcatgac ggcaaaacca tttttgaagg gttgaaaaat 84241 ccccttgttg cgacgcgata ccactcgctg atcgtaaaac ctgagacgct gccaagctgt 84301 tttacagtaa cagcacaaac gaaagaagga gaaatcatgg ctattcgcca caatgacctc 84361 ccgatagagg gtgtgcaatt tcacccagag tctattatga cctcctttgg gaaagaaatg 84421 ctcagaaatt ttattgagac atatcgcaag gaagttattg cgtgatgata tatgtgaacg 84481 gccggtatat ggaggagaaa gatgcagttc tttctccttt tgaccatggg tttttatatg 84541 ggatcggtgt tttcgaaacc ttcaggctct acgaaggctg cccgtttttg cttgattggc 84601 atatagagag gcttgaacgc gcgcttaagg atctgcaaat cgaatatact gtttcaaagc 84661 atgagatcct tgagatgctg gacaagctgc ttaagctaaa tgatatcaag gatggcaatg 84721 cccgcgtcag actgaacata tcagcgggaa tcagcgataa aggctttgtc gcccagacgt 84781 acgataagcc caccgtttta tgctttgtga atcagctgaa accagaaagt cttcctttgc 84841 aaaaagaagg aaaggtttta tcgatacgga gaaacactcc agagggatcg ttccggttaa 84901 aatctcatca ttatctaaat aatatgtatg cgaaacggga aattggaaat gatccgcgtg 84961 tcgagggaat tttcttaacg gaggatggag ctgttgcaga gggtatcata tctaatgtct 85021 tctggagaaa aggtcgctgt atctatacgc catcgcttga taccggtatt ctggacggcg 85081 tcacgagacg ttttatcata gaaaatgcaa aggatatcgg cctggagctc aaaacgggcc 85141 gatatgagct agaagctctc ttgacagctg acgaagcgtg gatgacgaac tcggttcttg 85201 aaatcatccc gtttactaaa atagaagaag taaactatgg aagccaaagc ggagaagcaa 85261 cctccgctct tcaattgtta tacaaaaaag aaataaagaa catgattcat gaaaagggag 85321 gaagagcatg gcgcagcaca caatagatca aacacaagta atccacacta agcccagcgc 85381 tttatcatat aaagagaaga cgctggtgat gggaatttta aacgtaacgc ctgactcttt 85441 ctcggacggc ggaaaatatg acagcttgga caaggcgctg ctgcacgcga aagagatgat 85501 cgatgatggt gcccatatca ttgatattgg aggggaatcg acaaggcctg gcgctgagtg 85561 cgtatctgag gatgaggaga tgtccagagt cattccggtg attgagcgga ttacgaaaga 85621 gcttggtgtt cctatttctg tagacacgta caaggcttct gtcgcagatg aagcagtgaa 85681 agccggtgca tccattatca atgatatttg gggagccaaa catgatccga agatggcttc 85741 cgttgcagct gaacataatg ttccaattgt actcatgcat aaccgccctg aaagaaacta 85801 caatgactta ttgccggata tgctgtcgga cttaatggag agtgtaaaaa ttgctgttga 85861 ggccggagta gacgagaaga acattattct tgatcctggt atcggtttcg cgaaaaccta 85921 tcacgataac ttggcagtga tgaacaaact agagattttc agcggattgg gatatccggt 85981 tcttctggca acctcccgaa aaagattcat cggacgtgtt ctggatcttc cgcctgagga 86041 gcgggctgag ggcacaggcg cgactgtgtg tctcggcatt caaaaaggct gtgacattgt 86101 cagggtccat gatgtaaagc aaattgccag aatggcgaaa atgatggacg cgatgctgaa 86161 taagggaggg gtgcaccatg gataaagttt atgtagaagg tatggagttt tacggatatc 86221 acggtgtgtt cacagaagaa aacaaacttg gccagcggtt taaagtcgat ttaaccgctg 86281 agctggattt aagcaaagct ggacagacag acgaccttga gcaaacgatc aactatgctg 86341 agctctatca cgtatgtaaa gatatcgtgg aaggggagcc tgtgaaattg gtggaaacgc 86401 tggcggaacg tattgctggc actgttctcg gaaaatttca gcctgttcag caatgtacgg 86461 tgaaagtgat taagccagac ccgccaattc ccggacacta taaatcagta gcaattgaaa 86521 ttacgagaaa aaagtcatga acaacatagc ttatattgca cttggatcta atattggaga 86581 tagagaaacg tatttaaggc aagcagtggc tttactgcat cagcatgctg cggtgacagt 86641 cactaaagtg tcgtctattt acgaaactga cccggtcgga tacgaagatc aagctcaatt 86701 tttgaatatg gctgttgaaa tcaagacatc attgaaccct tttgaactcc ttgaactgac 86761 gcagcagata gaaaatgaat taggcagaac aagggaagta agatgggggc cgcggacggc 86821 agaccttgac attttgttat ttaatcgtga aaatattgaa acagagcaac taattgttcc 86881 gcatccgaga atgtatgagc gtttgtttgt ccttgcgccg cttgcggaaa tttgccagca 86941 ggttgaaaaa gaggctacaa gcgccgaaac agaccaagaa ggtgtaagag tatggaagca 87001 gaaatctggg gtagacgaat tcgtgcattc agaaagctga aaggttatac tcaagaagga 87061 tttgcaaaag cattaggtat atcagtttct attctcggcg aaattgaacg cggaaaccga 87121 ttgccgtctg ctgccatcat tcaagatgca gcagatgttt taaatataag tgcggacgaa 87181 ttggcgccgc cagaaaaata gaacaaatga aaggaggaga aaaattgttc aaaatcggag 87241 atattcaatt gaaaaaccgg gttgtgctcg cacctatggc tggtgtctgc aactctgcgt 87301 tcagattgac tgtaaaggaa ttcggagccg gattggtatg cgctgaaatg gtcagtgaca 87361 aagcgatcct ttacaacaat gcaagaacaa tgggtatgct ttatattgat gaacgtgaga 87421 aaccactgag ccttcaaatt ttcggaggaa aaaaggaaac ccttgtggaa gcggcgaagt 87481 ttgtagacca aaacacaact gctgatatca ttgatattaa catgggatgt cccgtgccga 87541 agattacaaa atgcgatgcg ggagccaaat ggcttctcga tcctgataag atttacgaaa 87601 tggtttctgc agtagtggat gctgttaata agccagttac agtgaaaatg agaatgggct 87661 gggatgaaga ccacattttc gcagtgaaaa atgcacaggc tgtagaacgt gcgggcggta 87721 aagcagtggc gcttcacggc cgtacgagag tgcagatgta cgaaggaacg gcaaactggg 87781 atatcatcaa agaagtaaaa caatcagtat cgattccggt tatcggaaac ggcgatgtta 87841 agacaccgca ggatgctaag cgtatgctcg atgagacagg agtagacggg gtcatgatcg 87901 gacgcgctgc attgggtaac ccgtggatga tttaccgtac ggttcagtat cttgaaacag 87961 gtaaattaaa agaagagccg caagtacgcg aaaaaatggc cgtatgcaaa ctgcatcttg 88021 accgcctgat tgacttaaaa ggtgaaaacg tagcggtaag agaaatgaga aagcacgctg 88081 catggtatct gaaaggcgtg aaaggcaatg cgaacgttcg taatgaaatc aatcattgcg 88141 agacgagaga agagtttgta cagcttttag atgcatttac ggttgaagtt gaggcaaaag 88201 agcttcaaaa tgcaaaagta ggataatact cacctctatt tgctgctcac tgctagtttt 88261 acgctggcag tttttctgct tttttcatga aacaatatct gtaatggagt gataacaatg 88321 agtcaagaag agcataacca tgaagaattg aatgatcagc tgcaagtcag acgcgataaa 88381 atgaatcagc tgagagataa cggcatcgat ccattcggcg cacgttttga aagaactcat 88441 cagtctcaag aagttatttc ggcatatcaa gatctaacca aagaagagtt agaagaaaaa 88501 gcgattgaag ttacaatcgc aggccgcatg atgacaaaac gcggcaaagg aaaagccggc 88561 tttgcccatc ttcaggattt agaaggccaa atccaaatct acgtaagaaa agacagtgtc 88621 ggtgacgacc aatatgaaat cttcaagtct tctgacctcg gtgatcttat cggcgtaacc 88681 ggaaaagtct tcaaaacaaa tgtaggcgaa ttgtctgtta aagcaacttc ctttgaattg 88741 ctgacaaaag cgcttcgtcc gcttcctgac aaataccatg gtttaaaaga cgttgagcag 88801 cgctaccgtc agcgctatct ggatcttatc gtaaacccag acagcaaaca tacgttcatt 88861 acacgaagca agatcattca agctatgaga aggtaccttg atgatcatgg atacttagaa 88921 gtagaaacac ctacaatgca cagcattcct gggggagctt ctgcacgtcc gtttatcact 88981 caccacaacg cgttagacat tccactctat atgcgtattg ctatcgaact gcacctaaaa 89041 cgtctaattg tcggcggttt agaaaaagta tatgaaatcg gccgtgtttt ccgtaacgaa 89101 ggtgtctcta cacgccataa ccctgaattt acaatgattg agttatatga agcatatgcg 89161 gactataaag atatcatgag cttaactgaa aaccttgtcg ctcatatcgc ccaagaagtg 89221 cttggcacaa ctacgattca atacggggaa gagcaaatcg accttaaacc ggagtggaaa 89281 agaatccata tggttgacgc agtcaaagaa gcgaccggcg ttgatttctg ggaagaggtt 89341 actgttgagc aggcgcgtga atatgcaaaa gaacatgaag tagaaattaa agactctatg 89401 acagtaggcc atatcatcaa cgaattcttc gaacaaaaaa ttgaagaaac gcttattcag 89461 ccaacgttta tttacgggca tcctgtagaa atttctcctc ttgctaagaa aaaccctgag 89521 gacccgcgtt ttacagaccg ttttgagctg tttatcgttg gccgtgaaca tgccaacgcg 89581 tttacagagc tgaatgatcc tattgatcaa agagaacgct ttgaagcgca attaaaagag 89641 cgtgaagccg gtaatgatga agctcattta atggatgaag actttgttga agctctggaa 89701 tacggtatgc cgccaacagg aggtttaggc atcggtatcg accgtctggt tatgctgctg 89761 acgaatgccc cttctattcg cgatgtgctg ttattcccgc aaatgagaca acgctaataa 89821 aaaagagcgg tatcctccat agggaaagga tgccgctctt tttaaatccc ttagtatttc 89881 ttcaaaaaaa ctattgcact attatttact aggtggtata ttattattcg ttgccgctaa 89941 acaaggcgat aacgaaaaaa agaacttcaa aaaaagttat tgacttcact gagtcaacga 90001 gttataataa taaagtcgct tgaacgaagt gaacaaaatg atctttgaaa actaaacaag 90061 acaaaacgta cctgttaatt cagtttttaa aaatcgcaca gcgatgtgcg tagtcagtca 90121 aactacttta tcggagagtt tgatcctggc tcaggacgaa cgctggcggc gtgcctaata 90181 catgcaagtc gagcggacag atgggagctt gctccctgat gttagcggcg gacgggtgag 90241 taacacgtgg gtaacctgcc tgtaagactg ggataactcc gggaaaccgg ggctaatacc 90301 ggatggttgt ttgaaccgca tggttcaaac ataaaaggtg gcttcggcta ccacttgcag 90361 atggacccgc ggcgcattag ctagttggtg aggtaatggc tcaccaaggc aacgatgcgt 90421 agccgacctg agagggtgat cggccacact gggactgaga cacggcccag actcctacgg 90481 gaggcagcag tagggaatct tccgcaatgg acgaaagtct gacggagcaa cgccgcgtga 90541 gtgatgaagg ttttcggatc gtaaagctct gttgttaggg aagaacaagt gccgttcgaa 90601 tagggcggta ccttgacggt acctaaccag aaagccacgg ctaactacgt gccagcagcc 90661 gcggtaatac gtaggtggca agcgttgtcc ggaattattg ggcgtaaagg gctcgcaggc 90721 ggtttcttaa gtctgatgtg aaagcccccg gctcaaccgg ggagggtcat tggaaactgg 90781 ggaacttgag tgcagaagag gagagtggaa ttccacgtgt agcggtgaaa tgcgtagaga 90841 tgtggaggaa caccagtggc gaaggcgact ctctggtctg taactgacgc tgaggagcga 90901 aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa cgatgagtgc 90961 taagtgttag ggggtttccg ccccttagtg ctgcagctaa cgcattaagc actccgcctg 91021 gggagtacgg tcgcaagact gaaactcaaa ggaattgacg ggggcccgca caagcggtgg 91081 agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac atcctctgac 91141 aatcctagag ataggacgtc cccttcgggg gcagagtgac aggtggtgca tggttgtcgt 91201 cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgatcttagt 91261 tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga ggaaggtggg 91321 gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta caatggacag 91381 aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc tcagttcgga 91441 tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg atcagcatgc 91501 cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga gagtttgtaa 91561 cacccgaagt cggtgaggta accttttagg agccagccgc cgaaggtggg acagatgatt 91621 ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac ctcctttcta 91681 aggatatttt acggaatata agaccttggg tcttataaac agaacgttcc ctgtcttgtt 91741 tagttttgaa ggatcattcc ttcgaaacgt gttctttgaa aactagataa cagtagacat 91801 cacattcaag taatacaaga tatcacatag tgattctttt taacggttaa gttagaaagg 91861 gcgcacggtg gatgccttgg cactaggagc cgatgaagga cgggacgaac accgatatgc 91921 ttcggggagc tgtaagcaag ctttgatccg gagatttccg aatggggaaa cccaccactc 91981 gtaatggagt ggtatccata tctgaattca taggatatga gaaggcagac ccggggaact 92041 gaaacatcta agtacccgga ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc 92101 gaaacgggat tagcccaaac caagaggctt gcctcttggg gttgtaggac actctgtacg 92161 gagttacaaa ggaacgaggt agatgaagag gtctggaaag gcccgccata ggaggtaaca 92221 gccctgtagt caaaacttcg ttctctcctg agtggatcct gagtacggcg gaacacgtga 92281 aattccgtcg gaatccggga ggaccatctc ccaaggctaa atactcccta gtgaccgata 92341 gtgaaccagt accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc 92401 tgaaaccgtg tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt gccttttgta 92461 gaatgaaccg gcgagttacg atcccgtgca aggttaagca gaagatgcgg agccgcagcg 92521 aaagcgagtc tgaatagggc gcatgagtac gtggtcgtag acccgaaacc aggtgatcta 92581 cccatgtcca gggtgaagtt caggtaacac tgaatggagg cccgaaccca cgcacgttga 92641 aaagtgcggg gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg agatagctgg 92701 ttctctccga aatagcttta gggctagcct caaggtaaga gtcttggagg tagagcactg 92761 attggactag gggcccctac cgggttaccg aattcagtca aactccgaat gccaatgact 92821 tatccttggg agtcagactg cgagtgataa gatccgtagt cgaaagggaa acagcccaga 92881 ccgccagcta aggtcccaaa gtatacgtta agtggaaaag gatgtggagt tgcttagaca 92941 accaggatgt tggcttagaa gcagccacca tttaaagagt gcgtaatagc tcactggtcg 93001 agtgactctg cgccgaaaat gtaccggggc taaacgtatc accgaagctg cggactgttc 93061 ttcgaacagt ggtaggagag cgttctaagg gctgtgaagc cagaccggaa ggactggtgg 93121 agcgcttaga agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa tcccctccac 93181 cgaatgccta aggtttcctg aggaaggctc gtccgctcag ggttagtcgg gacctaagcc 93241 gaggccgaaa ggcgtaggcg atggacaaca ggttgatatt cctgtaccac ctcctcacca 93301 tttgagcaat ggggggacgc aggaggatag ggtaagcgcg gtattggata tccgcgtcca 93361 agcagttagg ctgggaaata ggcaaatccg tttcccataa ggctgagctg tgatggcgag 93421 cgaaatatag tagcgaagtt cctgattcca cactgccaag aaaagcctct agcgaggtga 93481 gaggtgcccg taccgcaaac cgacacaggt aggcgaggag agaatcctaa ggtgatcgag 93541 agaactctcg ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctct 93601 gttagggtgc aagcccgaga gagccgcagt gaataggccc aggcgactgt ttagcaaaaa 93661 cacaggtctc tgcgaagccg taaggcgaag tataggggct gacgcctgcc cggtgctgga 93721 aggttaagag gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg 93781 ccgtaactat aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac 93841 gaaaggcgca acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg 93901 tgaagatgca ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg 93961 atattgaatg ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca 94021 gcttcggtgg aggcatcggt gggatactac cctggctgta ttgaccttct aacccgccgc 94081 ccttatcggg cggggagaca gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa 94141 aaggtaacgg aggcgcccaa aggttccctc agaatggttg gaaatcattc gcagagtgta 94201 aaggcacaag ggagcttgac tgcgagacct acaagtcgag cagggacgaa agtcgggctt 94261 agtgatccgg tggttccgca tggaagggcc atcgctcaac ggataaaagc taccccgggg 94321 ataacaggct tatctccccc aagagtccac atcgacgggg aggtttggca cctcgatgtc 94381 ggctcatcgc atcctggggc tgtagtcggt cccaagggtt gggctgttcg cccattaaag 94441 cggtacgcga gctgggttca gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg 94501 caggaaattt gagaggagct gtccttagta cgagaggacc gggatggacg caccgctggt 94561 gtaccagttg ttctgccaag ggcatcgctg ggtagctatg tgcggacggg ataagtgctg 94621 aaagcatcta agcatgaagc ccccctcaag atgagatttc ccattccgca aggaagtaag 94681 atccctgaaa gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac acatggagct 94741 gacagatact aatcgatcga ggacttaacc atatttttga atgatgtcac atctgttatc 94801 tagttttgag agaacactct caatttgttt ggtggcgata gcgaagaggt cacacccgtt 94861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 94921 gtgagagtag gacgccgcca agcaattgca cgttagtgca attatggagg attagctcag 94981 ctgggagagc atctgcctta caagcagagg gtcggcggtt cgagcccgtc atcctccacc 95041 attatgccgg tgtagctcaa ttggtagagc aactgacttg taatcagtag gttgggggtt 95101 caagtcctct tgccggcacc acttttatat gatataatac tcaagtctct tgtagaagag 95161 ccattagctc agttggtaga gcatctgact tttaatcaga gggtcgaagg ttcgagtcct 95221 tcatggctca ccattttacg cgggtgtggc ggaattggca gacgcgctag acttaggatc 95281 tagtgtcttt atgacgtggg ggttcaagtc ccttcacccg cattatatag gataacagtt 95341 agaaaaactg gacatcctgt ctgcggaagt agttcagtgg tagaacacca ccttgccaag 95401 gtgggggtcg cgggttcgaa tcccgtcttc cgctccaact ataccatcca cgccggggtg 95461 gtggaattgg cagacacaca ggacttaaaa tcctgcggta ggtgactacc gtgccggttc 95521 aagtccggcc ctcggcatta tgttttgcgc ccgtagctca attggataga gcgtttgact 95581 acggatcaaa aggttagggg ttcgactcct ctcgggcgcg ccatatcttt taatagaata 95641 gataggaaat cgggaagtag ctcagcttgg tagagcacat ggtttgggac catggggtcg 95701 caggttcgaa tcctgtcttc ccgaccattt ttttatgggg ccttagctca gctgggagag 95761 cgcctgcttt gcacgcagga ggtcagcggt tcgatcccgc taggctccac caaaagtttt 95821 taaaaaagtt gttgactttg aagaagtgac gttgtatact aataaagttg ctttaacaaa 95881 gcggacaaac aaaatgatct ttgaaaacta aacaagacaa aacgtacctg ttaattcagt 95941 ttttaaaaat cgcacagcga tgtgcgtagt cagtcaaact actttatcgg agagtttgat 96001 cctggctcag gacgaacgct ggcggcgtgc ctaatacatg caagtcgagc ggacagatgg 96061 gagcttgctc cctgatgtta gcggcggacg ggtgagtaac acgtgggtaa cctgcctgta 96121 agactgggat aactccggga aaccggggct aataccggat ggttgtttga accgcatggt 96181 tcaaacataa aaggtggctt cggctaccac ttacagatgg acccgcggcg cattagctag 96241 ttggtgaggt aacggctcac caaggcaacg atgcgtagcc gacctgagag ggtgatcggc 96301 cacactggga ctgagacacg gcccagactc ctacgggagg cagcagtagg gaatcttccg 96361 caatggacga aagtctgacg gagcaacgcc gcgtgagtga tgaaggtttt cggatcgtaa 96421 agctctgttg ttagggaaga acaagtaccg ttcgaatagg gcggtacctt gacggtacct 96481 aaccagaaag ccacggctaa ctacgtgcca gcagccgcgg taatacgtag gtggcaagcg 96541 ttgtccggaa ttattgggcg taaagggctc gcaggcggtt tcttaagtct gatgtgaaag 96601 cccccggctc aaccggggag ggtcattgga aactggggaa cttgagtgca gaagaggaga 96661 gtggaattcc acgtgtagcg gtgaaatgcg tagagatgtg gaggaacacc agtggcgaag 96721 gcgactctct ggtctgtaac tgacgctgag gagcgaaagc gtggggagcg aacaggatta 96781 gataccctgg tagtccacgc cgtaaacgat gagtgctaag tgttaggggg tttccgcccc 96841 ttagtgctgc agctaacgca ttaagcactc cgcctgggga gtacggtcgc aagactgaaa 96901 ctcaaaggaa ttgacggggg cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa 96961 cgcgaagaac cttaccaggt cttgacatcc tctgacaatc ctagagatag gacgtcccct 97021 tcgggggcag agtgacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg 97081 ttaagtcccg caacgagcgc aacccttgat cttagttgcc agcattcagt tgggcactct 97141 aaggtgactg ccggtgacaa accggaggaa ggtggggatg acgtcaaatc atcatgcccc 97201 ttatgacctg ggctacacac gtgctacaat ggacagaaca aagggcagcg aaaccgcgag 97261 gttaagccaa tcccacaaat ctgttctcag ttcggatcgc agtctgcaac tcgactgcgt 97321 gaagctggaa tcgctagtaa tcgcggatca gcatgccgcg gtgaatacgt tcccgggcct 97381 tgtacacacc gcccgtcaca ccacgagagt ttgtaacacc cgaagtcggt gaggtaacct 97441 tttaggagcc agccgccgaa ggtgggacag atgattgggg tgaagtcgta acaaggtagc 97501 cgtatcggaa ggtgcggctg gatcacctcc tttctaagga tattttacgg aatataagac 97561 cttgggtctt ataaacagaa cgttccctgt cttgtttagt tttgaaggat cattccttcg 97621 aaacgtgttc tttgaaaact agataacagt agacatcaca ttcaagtaat acaagatatc 97681 acatagtgat tctttttaac ggttaagtta gaaagggcgc acggtggatg ccttggcact 97741 aggagccgat gaaggacggg acgaacaccg atatgcttcg gggagctgta agcaagcttt 97801 gatccggaga tttccgaatg gggaaaccca ccactcgtaa tggagtggta tccatatctg 97861 aattcatagg atatgagaag gcagacccgg ggaactgaaa catctaagta cccggaggaa 97921 gagaaagcaa atgcgattcc ctgagtagcg gcgagcgaaa cgggatcagc ccaaaccaag 97981 aggcttgcct cttggggttg taggacactc tgtacggagt tacaaaggaa cgaggtagat 98041 gaagaggtct ggaaaggccc gccataggag gtaacagccc tgtagtcaaa acttcgttct 98101 ctcctgagtg gatcctgagt acggcggaac acgtgaaatt ccgtcggaat ccgggaggac 98161 catctcccaa ggctaaatac tccctagtga ccgatagtga accagtaccg tgagggaaag 98221 gtgaaaagca ccccggaagg ggagtgaaag agatcctgaa accgtgtgcc tacaagtagt 98281 cagagcccgt taacgggtga tggcgtgcct tttgtagaat gaaccggcga gttacgatcc 98341 cgtgcaaggt taagcagaag atgcggagcc gcagcgaaag cgagtctgaa tagggcgcat 98401 gagtacgtgg tcgtagaccc gaaaccaggt gatctaccca tgtccagggt gaagttcagg 98461 taacactgaa tggaggcccg aacccacgca cgttgaaaag tgcggggatg aggtgtgggt 98521 aggggtgaaa tgccaatcga acctggagat agctggttct ctccgaaata gctttagggc 98581 tagcctcaag gtaagagtct tggaggtaga gcactgattg gactaggggc ccctaccggg 98641 ttaccgaatt cagtcaaact ccgaatgcca atgacttatc cttgggagtc agactgcgag 98701 tgataagatc cgtagtcgaa agggaaacag cccagaccgc cagctaaggt cccaaagtat 98761 acgttaagtg gaaaaggatg tggagttgct tagacaacca ggatgttggc ttagaagcag 98821 ccaccattta aagagtgcgt aatagctcac tggtcgagtg actctgcgcc gaaaatgtac 98881 cggggctaaa cgtatcaccg aagctgcgga ctgttcttcg aacagtggta ggagagcgtt 98941 ctaagggctg tgaagccaga ccggaaggac tggtggagcg cttagaagtg agaatgccgg 99001 tatgagtagc gaaagagggg tgagaatccc ctccaccgaa tgcctaaggt ttcctgagga 99061 aggctcgtcc gctcagggtt agtcgggacc taagccgagg ccgaaaggcg taggcgatgg 99121 acaacaggtt gatattcctg taccacctcc tcaccatttg agcaatgggg ggacgcagga 99181 ggatagggta agcgcggtat tggatatccg cgtccaagca gttaggctgg gaaataggca 99241 aatccgtttc ccataaggct gagctgtgat ggcgagcgaa atatagtagc gaagttcctg 99301 attccacact gccaagaaaa gcctctagcg aggtgagagg tgcccgtacc gcaaaccgac 99361 acaggtaggc gaggagagaa tcctaaggtg atcgagagaa ctctcgttaa ggaactcggc 99421 aaaatgaccc cgtaacttcg ggagaagggg tgctctgtta gggtgcaagc ccgagagagc 99481 cgcagtgaat aggcccaggc gactgtttag caaaaacaca ggtctctgcg aagccgtaag 99541 gcgaagtata ggggctgacg cctgcccggt gctggaaggt taagaggagc gcttagcgta 99601 agcgaaggtg cgaattgaag ccccagtaaa cggcggccgt aactataacg gtcctaaggt 99661 agcgaaattc cttgtcgggt aagttccgac ccgcacgaaa ggcgcaacga tctgggcact 99721 gtctcaacga gagactcggt gaaattatag tacctgtgaa gatgcaggtt acccgcgaca 99781 ggacggaaag accccgtgga gctttactgc agcctgatat tgaatgttgg tacagcttgt 99841 acaggatagg taggagcctt ggaaaccgga gcgccagctt tggtggaggc atcggtggga 99901 tactaccctg gctgtattga ccttctaacc cgccgccctt atcgggcggg gagacagtgt 99961 caggtgggca gtttgactgg ggcggtcgcc tcctaaaagg taacggaggc gcccaaaggt 100021 tccctcagaa tggttggaaa tcattcgcag agtgtaaagg cacaagggag cttgactgcg 100081 agacctacaa gtcgagcagg gacgaaagtc gggcttagtg atccggtggt tccgcatgga 100141 agggccatcg ctcaacggat aaaagctacc ccggggataa caggcttatc tcccccaaga 100201 gtccacatcg acggggaggt ttggcacctc gatgtcggct catcgcatcc tggggctgta 100261 gtcggtccca agggttgggc tgttcgccca ttaaagcggt acgcgagctg ggttcagaac 100321 gtcgtgagac agttcggtcc ctatccgtcg cgggcgcagg aaatttgaga ggagctgtcc 100381 ttagtacgag aggaccggga tggacgcacc gctggtgtac cagttgttct gccaagggca 100441 tcgctgggta gctatgtgcg gacgggataa gtgctgaaag catctaagca tgaagccccc 100501 ctcaagatga gatttcccat tccgcaagga agtaagatcc ctgaaagatg atcaggttga 100561 taggtctgag gtggaagtgt ggcgacacat ggagctgaca gatactaatc gatcgaggac 100621 ttaaccatat ttttgaatga tgtcacatct gttatctagt tttgagagaa cactctcaat 100681 ttgtttggtg gcgatagcga agaggtcaca cccgttccca taccgaacac ggaagttaag 100741 ctcttcagcg ccgatggtag tcgggggttt ccccctgtga gagtaggacg ccgccaagca 100801 agcttaaacc cagctcaatg agctgggttt tttgtatttt ggtttattgg tatcataaaa 100861 ttccacttaa ctgtataata taataacttt ataccgaatt ttaaatcagc aatcaggttt 100921 tgtggaccgg gaaaatggaa ataatgaagg atagagcgag aaagttgaaa attctcgaga 100981 aacggcttat agtaagatta aagtcaaata tagtcaaagt cagtaaagga gggggttgag 101041 tgggacataa tatttctgac atcattgaac aatatttaaa acgagtgtta gatcaaaatg 101101 gcaaggaaat tttagagatt aaacgaagtg aaattgcaga taaatttcaa tgcgttcctt 101161 cccaaataaa ttatgtcatc aacaccagat ttacaagcga aagaggatat attgttgaga 101221 gcaaacgcgg gggcggcggt tacatcagaa tcattaaaat taaaatgaac aatgaagttg 101281 tcctgatcaa taatataatt tctcaaatta atacccattt gtctcaagca gcctctgatg 101341 acattatttt aaggctatta gaagacaagg taatttcaga aagagaagca aaaatgatgg 101401 tcagcgtaat ggaccgctca gttttacaca ttgacttacc tgaacgtgat gaattaagag 101461 cgagaatgat gaaggcaatg ctgacttctt taaaattaaa ataagcgggt gaaaagattg 101521 atttgtcaag agtgccacga gagaccagcc acttttcact ttacaaaggt tgttaacgga 101581 gaaaaaatag aagttcatat ttgtgaacaa tgtgccaaag aaaatagtga ttcatatggt 101641 ataagtgcaa atcagggttt ctctattcat aatttacttt cgggtttact gaacatggat 101701 tcttcatttc aaaatgcagg aactcaaatg ttcagtcact cggagcaaat atctgcttgt 101761 ccgaaatgcg gaatgacttt tcagcaattc agaaaaattg gccgttttgg atgttctgaa 101821 tgttacaaaa catttcatag caacattaca ccaatcctac gtaaagtgca cagcggaaac 101881 actgtgcatg caggtaagat accgaaacga ataggcggca atcttcatgt cagacggcag 101941 attgatatgc taaaaaagga attagaatcc ttaatccatc aagaagaatt tgaaaatgca 102001 gctcatgtaa gagatcaaat tcgtttatta gaacaatcac tcaaaagtac agatagtgag 102061 gaggaacagg agtaatgtcg ctaaagcatt ttattcagga cgcactaagc agttggatga 102121 agcagaaagg acctgaaagt gacattgtac tcagcagccg catacgttta gcaagaaact 102181 ttgagcatat tcggttccct acgcggtatt ccaatgaaga agcctcatcc atcatacagc 102241 aatttgaaga tcagttttca gagcaagaaa ttcccggaat cggcaaattt gttttgatta 102301 gaatgaatga tgcacagcct ttagaaaagc gtgtacttgt tgaaaaacat ctaatcagcc 102361 cgaatttgac agagtctcct tttggcggct gtttgctttc tgaaaatgag gaagtaagcg 102421 tcatgctaaa tgaagaggac catattagaa ttcagtgtct tttccctgga tttcagcttt 102481 tagaagcaat gaaagccgca aaccaggtcg acgactggat tgaagaaaaa gttgattatg 102541 cattcaatga gcaaagagga tacttaacca gctgtcctac aaacgtaggt actggtttaa 102601 gggcttcggt catgatgcat ctgccggcgc tggttttaac taggcaaata aatcgaatta 102661 taccggcaat taatcaatta ggcttagttg ttagaggaat ttatggggaa ggcagcgaag 102721 cagtagggaa tatctttcaa atttcaaatc agatcacgct tggtaagtca gagcaggata 102781 ttgtagagga tcttaacagt gttgctgctc agttgattga acaagaacga tctgcccgag 102841 aagcgattta tcaaacttct aaaatcgaac ttgaggatcg ggtatatcgg tcatatgggg 102901 tcttgtctaa ttgccggatg atagaatcga aagaaactgc aaagtgcctt tcagatgttc 102961 ggttaggcat agacttaggc ataataaaag gactttcaag caacatactt aacgaactta 103021 tgattttgac gcagccaggg tttttacagc aatactcggg aggcgctttg cgaccgaacg 103081 aaagggacat tcgaagagcg gctctcatca gagaacggct tcacttagaa atgaatggga 103141 aaagacagga ggatgaatcg atatgatgtt tggaagattt acagaacgag ctcaaaaagt 103201 actggcgcta gcacaggaag aagcacttcg gttaggtcat aataacattg gcactgagca 103261 tattttatta ggactggtaa gagaaggaga gggcattgct gctaaagctc ttcaagcgct 103321 tggactcggt tcagaaaaaa ttcagaaaga agtagaaagt ttgatcgggc gcgggcagga 103381 aatgtctcaa acgattcatt atactcctag agctaaaaaa gtcattgagc tttcaatgga 103441 tgaggcaaga aaactcggtc attcttatgt gggaacagaa catattcttc ttggtctgat 103501 tcgtgaagga gaaggtgttg ctgcgagagt tctgaataat ctcggtgtca gcttaaataa 103561 agcaagacag caggtgctcc agcttctagg aagtaatgaa acaggatcat cagcggcagg 103621 aacaaacagc aatgcgaata cgcctacgct tgacagcttg gcaagagact taactgctat 103681 tgcgaaggaa gacagccttg accctgtaat cggcagaagc aaggagatcc agcgtgtcat 103741 tgaagtgtta agccgcagaa cgaaaaacaa ccctgttctc attggggaac caggtgtagg 103801 taaaacggct atcgcagaag gtttggcaca gcaaattatc aataatgaag tacccgaaat 103861 tttgcgtgat aaacgtgtga tgacattaga catgggaaca gttgttgccg gcacaaaata 103921 ccgcggagaa tttgaggatc gcctgaagaa ggtcatggat gaaattcgcc aggcaggaaa 103981 tatcattcta ttcatcgatg agctccatac attaatcggg gcaggcggag cagaaggtgc 104041 tattgatgca tctaatattt taaaaccttc acttgctcgt ggcgaactcc aatgtattgg 104101 tgcaacgact cttgatgagt accgtaaata tattgaaaaa gatgcagcac tggaacgccg 104161 ttttcagccg attcaggttg atcagccatc tgtagatgaa agtattcaaa ttttacaagg 104221 tctgcgtgac agatacgaag cccaccaccg cgtttctatc actgatgatg ccattgaagc 104281 tgcggttaag ctttctgaca gatatatttc tgaccgcttc cttccggata aagcaattga 104341 cttgatcgat gaagcgggtt caaaggtgag actgcgctca tttacaacgc ctcctaactt 104401 aaaagagctt gagcagaagc ttgatgaggt tcgtaaagag aaggatgcgg cagtgcaaag 104461 ccaagagttt gaaaaagctg cttccttgcg tgatactgaa caacgcctgc gcgagcaagt 104521 agaggatacg aagaaatcat ggaaagagaa gcaagggcag gaaaactcag aggttactgt 104581 ggatgatatt gcgatggttg tatccagctg gaccggtgtg cctgtatcta aaatcgccca 104641 aactgaaact gataagcttc tcaatatgga aaacattctt cactcccgtg tcatcggcca 104701 ggatgaagca gttgtagcgg ttgcaaaagc cgtcagacgt gcaagagcag gattgaaaga 104761 tcctaaacgc ccaatcggct cattcatttt cttaggccct acaggtgtag gtaaaacaga 104821 acttgcacga gcacttgctg aatccatttt tggcgatgaa gaatccatga tcagaattga 104881 tatgtctgaa tacatggaaa aacattcaac ttcaagactt gttggttcac ctccgggtta 104941 tgtgggatat gatgaaggcg gtcaattgac agagaaagtc agaagaaaac cttactctgt 105001 cgtgcttctt gatgagatcg agaaagcgca ccctgatgtc ttcaatatcc ttctgcaagt 105061 tcttgaagac ggacgattga ctgattctaa aggacgcaca gtcgatttcc gcaataccat 105121 tctgatcatg acatcaaacg tcggagcaag tgagctaaaa cgcaataaat atgtcggctt 105181 taacgttcag gatgaaactc aaaatcataa agacatgaaa gataaagtga tgggtgaatt 105241 aaaacgagcg ttcagacctg agttcatcaa ccgtattgat gaaatcattg tcttccattc 105301 acttgagaaa aaacatctca ctgagattgt gtcattaatg tctgatcaat taacgaaacg 105361 cctgaaagaa caagatcttt ctatcgaatt gacagatgct gcaaaagcga aagtcgcgga 105421 agagggcgtt gacctggaat acggtgcccg tccgttaaga agagcgatcc aaaaacatgt 105481 cgaggatcgt ttatctgaag aactcctcag aggaaatatt cataaaggac agcatattgt 105541 tcttgatgta gaagatggcg aatttgtcgt aaaaacgact gctaaaacga attaatatag 105601 aagacggaaa tgaggcatac agcatgtaag tgtatgcctc actttcatat caagaaatag 105661 aacaagggag aggtcttaca ctatatatgg ctaaaacaaa atcgaagttc atctgccaat 105721 cctgcggcta cgagtctcca aaatggatgg ggaaatgtcc gggctgtggt gcttggaata 105781 caatggtgga agaaatgatt aaaaaagcac cggccaatcg gagagcggct ttttctcatt 105841 ctgttcaaac tgtacagaaa ccttcaccta ttacatcaat cgaaacatca gaagaacccc 105901 gcgtcaaaac ccagcttggc gagtttaaca gagtactcgg cggaggtgtc gttaaaggct 105961 ccctcgtttt aattggcggt gatcctggta tcggaaagtc aacgctatta ctgcaggttt 106021 ccgctcaatt atcaggctca tcaaacagtg tcctgtatat ttcgggagaa gaatctgtaa 106081 agcaaacgaa gctgcgagca gaccgtctcg gcattaataa tccgtcactg catgttttat 106141 ctgaaaccga tatggagtat atttcgtctg ctatacaaga gatgaatcca tcgtttgtcg 106201 ttgttgactc tattcaaacg gtttaccaaa gcgatattac atctgctcca ggcagtgtgt 106261 cacaggtcag agaatgtacc gctgagctga tgaaaattgc aaaaacaaaa ggtattccga 106321 tttttatcgt agggcacgtg acgaaagaag ggtctattgc aggtccgaga ctgttggagc 106381 atatggttga cactgtttta tattttgaag gagaacgcca ccatactttc cgtattttgc 106441 gggctgtaaa aaaccgtttc ggatctacaa acgaaatggg cattttcgaa atgcgggaag 106501 aggggctcac tgaggttttg aatccttcgg aaattttctt agaagaacgc tctgctggtt 106561 ccgcaggctc gagtatcact gcctctatgg agggcactag accgattctc gttgaaattc 106621 aggcactcat ctcgccaaca agttttggca acccaaggcg tatggcaacg ggaatagacc 106681 ataacagggt ttctctgtta atggctgtgt tagaaaaaag agttggactg ctgctgcaaa 106741 atcaggatgc ttatttgaaa gtggctggcg gcgttaagct tgatgaaccg gcaattgatc 106801 ttgcgattgt gattagtatt gcatcaagct ttagagacac acctccaaat cctgcagatt 106861 gttttattgg agaagtggga ttaaccggag aagtccggcg ggtttcaaga attgaacagc 106921 gtgtgaaaga agcggcaaag cttggtttta aacgcatgat catacccgcg gcaaatctgg 106981 atggatggac aaaaccaaaa gggattgagg ttatcggagt agcaaatgtt gcagaagcgc 107041 ttcgtacttc attaggagga taatagatgg aaaaagagaa aaaaggggcg aaacacgagt 107101 tagacctgtc atctatattg cagtttgttg ctccgggtac accgctcaga gcggggatgg 107161 aaaacgtctt gagagcaaat acaggcggtc tgattgttgt tggatataat gataaagtaa 107221 aagaagtggt ggacggcggc tttcacataa acacggcttt ttctccggcg catttatatg 107281 agctggctaa aatggatgga gcgatcattt taagtgattc tggtcaaaag atcctatacg 107341 cgaatactca gctgatgccg gatgccacaa tttcttcatc agaaacagga atgcggcaca 107401 gaactgccga aagagtagct aagcaaactg gctgtcttgt aatcgccatt tctgaaagaa 107461 gaaatgtcat aacgttatat caggaaaaca tgaagtatac actaaaagac ataggattta 107521 ttttaaccaa ggcgaaccaa gccattcaaa cacttgaaaa atataagaca atcctcgata 107581 aaacgattaa tgcactgaac gcgttagagt ttgaggaact tgttaccttc agtgatgtct 107641 tgtctgtcat gcatcgttat gaaatggtac tgagaatcaa aaacgaaatt aatatgtata 107701 tcaaagagct ggggacagaa gggcatctga tcaaactgca agtcattgaa ttgattacgg 107761 atatggaaga agaggccgct ttatttatta aggactatgt aaaagaaaag attaaagatc 107821 cgtttgttct cttgaaggag ctgcaggata tgtccagtta tgatctgctg gatgattcca 107881 ttgtgtataa gcttctcggt taccctgctt ctactaatct tgatgattat gtattgccga 107941 gaggatacag gctgttaaat aagataccgc gtcttccgat gccgattgtt gaaaatgttg 108001 tagaagcatt tggagtcctg ccaaggatta ttgaggcgag tgcagaagaa ttagatgaag 108061 tagagggaat cggtgaagta cgagcccaaa aaatcaaaaa aggattaaaa cgcctgcaag 108121 agaagcatta tttagacaga caactgtgat ttcggttaaa accttatgaa tacgggtata 108181 ttaatgttgg tttttgttta ttctgatatt cgtaggatgc ataagacttt gtgaaattaa 108241 aatgttaaaa aaggaggtgg gggtatgtta aaacgaatag ttcaggcgtt cttcattatt 108301 tttggcggcg ttgttggtat atttttgata cctgaattgt ttgtactgtt aaatatacag 108361 gacatacctt taataacaaa cgcatatacg tctgcggcaa taggagcaat tatctttttt 108421 ctcatcagta tatggggtac agaatacgtt gtgaactggg tgaagtggat agaggattca 108481 ttgttaaaag cgccggttcc agatttgtta tttggaagtc ttggcttagt ttttggactt 108541 ataattgctt atcttatcgt aaatgttatt cctttagaca atatacctta ccgcatattc 108601 agcacaataa ttcctgtatt tttggctttc ttcctcggtt atctcggctt ccaggtgggc 108661 tttaagaaaa aggatgaatt gatcagcctg ttttccattt ccgccagaat gcaaaagaaa 108721 aaaggaacag ctgatgaaga acatgaggtt caagacaaga agctgaaaat tttggacact 108781 agtgttatta ttgatgggag aatagcagat atttgtcaga ctggtttttt agagggagtt 108841 atcgtgattc cgcagtttgt ccttgaggaa ttgcagcata ttgcagactc ttcagatgtt 108901 ttaaaacgaa acagaggacg ccgcggtctt gatatcctga accgcattca gaaagaatta 108961 gacattgaag ttgaaattta cgaaggcgac tttgaagata ttcaggaggt tgacagcaag 109021 ctcgtcaaac ttgctaagct gacatccggg gtcgttgtga cgaatgattt taatttaaat 109081 aaagtgtgcg agcttcagaa ggtagcagta ttaaacatta atgaccttgc caatgcggtt 109141 aagcctgttg tgcttcctgg cgaggaaatg aatgttcagg tcattaagga cgggaaagag 109201 cataatcagg gagttgccta cttggatgac ggtacgatga ttgtcgttga agaaggacgg 109261 aattatatcg gcaagcatat tgatgtactc gtcacaagtg tgctgcagac agcagcggga 109321 cgaatgattt ttgcgaagcc taagctgttg gagaaggcgc tgtaaaggga gaagaaacaa 109381 tgagttatga tgtggtgatt cctgcagccg gacagggaaa gcggatgaag gcagggagaa 109441 ataaactgtt cattgagctg aagggagacc cggtgatcat acacacgtta agagtgtttg 109501 acagccaccg gcagtgcgat aaaatcattt tggtgattaa cgagcaggag cgggagcact 109561 ttcagcaatt gctgtccgat tacccgtttc aaacttcaat tgagcttgtt gcaggcggag 109621 atgagcgaca gcacagtgtg tataaggggc tgaaagccgt aaagcaggaa aagattgtcc 109681 ttgtacatga cggtgcccgt ccatttataa aacatgaaca aattgacgaa ctgatcgcag 109741 aggcggaaca gacaggagcg gccatccttg ctgttccggt aaaagatacg attaaacgcg 109801 ttcaagattt acaagtcagt gagacgattg aacgttcaag cttgtgggct gtccaaacgc 109861 cacaagcttt tcgtctttct ttattgatga aggctcacgc tgaggccgag cgcaagggat 109921 ttttagggac ggatgacgcc agcctcgttg aacagatgga gggcggttcg gtccgtgttg 109981 tagaaggcag ctatacaaat attaagctga cgacgccaga cgatttgacg tcagctgaag 110041 ctatcatgga atcagaaagt gggaataaac atgtttagaa ttggacaagg atttgatgtg 110101 catcaattag tggagggccg tcctctcatt attggcggaa ttgaaatccc gtacgaaaaa 110161 gggctgcttg gccattctga tgcagacgta ttgttgcata ccgtcgctga cgcctgcctg 110221 ggagctgtgg gtgaaggaga cataggcaag cattttcctg acacagatcc cgagttcaag 110281 gacgcagatt ctttcaaatt acttcagcat gtctggggaa tcgtgaaaca gaaggggtat 110341 gtccttggga acattgattg caccatcata gcgcaaaagc cgaagatgct gccgtacata 110401 gaagatatga gaaaaagaat tgctgaaggc cttgaggcag atgtttctca agtaaatgta 110461 aaagcaacaa cgacagaaaa gcttggattt acaggccggg cggaaggaat agcggctcag 110521 gcgacagtac tgatacaaaa aggctaactt gttttgatgc cgggtctatt tggtggtaga 110581 atagattcat acatttttgc ctgaggccat acatgacatg aaaggaagta tttgaaaatg 110641 ggaaacgaag tacgcgtccg ttatgcaccg agtccaaccg gacatttgca tattggaaat 110701 gccagaacgg cgctttttaa ttatttattt gcccgcaatc aaggcggtaa gtttatcatt 110761 cgagttgagg atactgataa aaagcgcaat attgagggcg gagaacaaag ccagctgaat 110821 tatctgaagt ggctaggtat tgactgggat gagagtgtgg atgtcggagg agagtacggt 110881 ccataccgtc agtcagagcg taacgatatc tataaagtgt actatgaaga gcttcttgaa 110941 aaagggcttg cttataaatg ttactgtacg gaagaagagc ttgaaaaaga gcgtgaagaa 111001 cagattgccc gcggagaaat gcctcgttat tccggaaaac acagagacct gactcaggaa 111061 gaacaggaga aatttatcgc cgaaggcaga aaaccaagta ttcgtttccg tgtgccggaa 111121 ggaaaagtca tcgccttcaa cgacatcgta aaaggcgaaa tttcttttga atcagatggc 111181 atcggcgact tcgttattgt gaaaaaggac ggaacgccta cttataactt cgcggtagct 111241 attgatgact acttaatgaa aatgacacac gtgctgcgcg gtgaggatca tatttctaac 111301 acaccgaaac agattatgat ctatcaagca ttcgggtggg atattcctca gttcggacac 111361 atgacgctga ttgtaaacga aagccgtaaa aagctcagca aacgtgatga atccattatt 111421 caattcatcg agcagtacaa agagcttggc tacctgccag aagcgctgtt caactttatc 111481 ggcttgttag gctggtcacc ggttggagaa gaagagcttt tcacaaaaga gcagtttatt 111541 gaaatttttg atgtaaatcg tttatctaaa tcaccagctt tgtttgatat gcataagcta 111601 aaatgggtta acaaccaata tgtgaagaag ctggatcttg atcaggttgt tgaactgacg 111661 cttccgcatt tgcaaaaagc cggcaaagtt ggcactgagc tttctgctga agaacaagaa 111721 tgggttcgta aactgatttc cctgtatcat gagcaattaa gctacggtgc ggaaattgtt 111781 gagctgactg atttgttctt tacggatgag atcgagtata atcaagaagc gaaagctgtt 111841 ctggaagaag aacaggttcc tgaagtgctc agcacattcg cagcgaagct tgaagagctt 111901 gaggagttca ctccggataa tatcaaagca tcgatcaaag cagtgcagaa agaaactggc 111961 cataaaggga aaaaactgtt tatgccgatt cgtgttgctg taacagggca aactcacggt 112021 ccggaactgc cgcaatcaat tgaattgatc ggtaaagaga ctgcaattca gcgtttaaag 112081 aatatctaaa taaatgattg ttgacaggga agagtataaa gctttaggcc attacagaaa 112141 ggatcttcat tggctgagag agatccatga gccgggtttt agaagtgcgc ccttaagacc 112201 tttgaagaac gttttttgaa atcagtattc aaaggcggcc gccgccgtta caggctgaag 112261 ttgggagagc agaagtctgc ttttcaaaca gagtggaacc gcgcggttaa agcgtctctg 112321 tcatgtttac atgcagagac gcttttttta ttgggtagag gaaatcagat agagaaacgg 112381 ggggaagcat gtgtttttta gaatgctcaa agaagacatt gatactgtgt tcgatcaaga 112441 tcccgcagca agaagctatt ttgaagtgat tttaacttat tccggtttac atgctatatg 112501 ggcgcatcgg attgcacatg ctttatataa acgaaaattt tatttccttg cacgccttat 112561 atctcaagta agccgatttt ttaccgggat agaaatccac cccggcgcta caatcgggag 112621 aagatttttc atagaccacg gcatgggggt tgtcattggg gagacatgtg aaatcggcaa 112681 taacgtaacc gtttttcagg gggttaccct cgggggaacg ggaaaagaaa agggaaaaag 112741 gcacccaacg attaaagatg acgcattgat agccacaggt gctaaagtgc tcggttctat 112801 tacggtcggt gaaggctcaa agattggcgc tggttcagta gtgctgcatg atgttcctga 112861 tttttcaaca gttgtcggta tccctggacg ggtcgttgta caaaatggca agaaagtaag 112921 acgcgattta aaccatcagg atttgcccga tccagttgct gaccgcttta agtctttgga 112981 acagcagatt ttagagctga aggcagaact tgaagacaga aaagaaagga tcaatcaaaa 113041 atgacaatca cactttataa tacattgact agacagaagg aaacattcgt tcctcttgaa 113101 gagggaaaag tgaaaatgta tgtatgcgga cccacggttt acaattacat tcatatcggg 113161 aacgcgcgtc cggcaatcgt ttacgatacg gttcgaaact atttagagta taaaggctat 113221 gatgtgcagt atgtctctaa cttcacagac gtagacgata aattaattaa agcggcaaat 113281 gaactcggtg aggatgtacc caccatttca gagcgtttta ttaaagcata ctttgaagac 113341 gtaggtgcgc tcggctgccg aaaagccgac cttcatccgc gagtaatgga gaacatggat 113401 gccattatcg aattcgtaga tcagctcgtg aaaaagggct acgcatatga atcagaaggt 113461 gacgtatatt tcaaaaccag agcatttgaa gggtacggaa agctttctca gcaatcaatc 113521 gatgaactaa gatcaggtgc acgcatccgg gtcggcgaga aaaaagaaga tgctcttgat 113581 ttcgcactgt ggaaagcggc aaaagaagga gaaatctctt gggatagccc ttgggggaaa 113641 gggcgtccgg gctggcacat tgaatgctca gcaatggtga aaaagtatct cggtgaccag 113701 attgatatcc atgcgggcgg acaggattta acattccctc accatgaaaa cgaaattgcg 113761 caatctgagg cgctgacagg caaaacgttt gcgaagtact ggcttcataa tggttatatc 113821 aatattgata atgaaaaaat gtcaaaatca ctaggcaact ttgtgcttgt gcatgacatc 113881 attaaacagc atgatccgca gcttttgaga ttctttatgc tatctgttca ttatcgccat 113941 ccgattaact attcagaaga gcttctggag aatacgaaaa gcgcgttcag ccgtttaaaa 114001 acagcgtaca gcaatcttca gcaccgtctg aacagcagta cgaatttaac cgaagatgac 114061 gatcaatggc ttgaaaaggt tgaagaacac cgcaaagcat tcgaagaaga gatggacgat 114121 gattttaata cggcgaatgc catttcagtc ttgtttgact tagcgaaaca cgccaattat 114181 tatcttcaga aagatcatac ggctgatcat gtgattacgg cgtttattga gatgtttgac 114241 cgcattgttt ctgtcctcgg tttttcgttg ggtgagcagg aacttctcga tcaagagatt 114301 gaagacttaa tcgaaaagcg aaatgaagcg cgccggaatc gcgattttgc attgtcagac 114361 cagatccgcg accagctgaa aagcatgaat atcattcttg aagatacggc tcaaggcact 114421 cgctggaaac ggggagaata acagatgctt gaatttgata cgataaaaga ttctaagcag 114481 cttaacggtc ttgcgcttgc ttatataggt gatgccattt ttgaagtgta tgtcaggcat 114541 cacctgctta agcagggctt taccaaacca aatgatcttc ataagaaatc aagccggatt 114601 gtttcagcaa agtcacaggc tgagatccta ttttttctgc agaatcaatc attttttacg 114661 gaagaagagg aagcggtgct gaaaagaggc agaaatgcca agtcagggac aacacctaaa 114721 aatacagatg ttcagacgta ccgctacagt acagcatttg aagcgcttct gggctacctt 114781 tttctagaga aaaaagagga acgacttagt cagctcgtag ccgaagctat acaattcggg 114841 acgtcaggga ggaaaacaaa tgagtcagca acatgattac gtcataggga aaaatgcagt 114901 gatcgagacg ttaaaatctg atcggaagct gtataagctg tggatggcgg aaaacaccgt 114961 aaagggacaa gcacagcaag tgattgagct tgccaaaaag cagggaatca cgattcaata 115021 cgtcccgaga aaaaaactcg atcaaatggt gacaggacag catcagggcg tagtggcaca 115081 ggttgcagcg tatgaatatg cagaactgga cgatttatat aaagcagccg aagaaaaaaa 115141 tgaacagcct ttcttcctca ttctggacga gcttgaagac cctcataatc ttggttccat 115201 tatgaggaca gcagatgcgg tcggcgctca tggcatcgtc attccaaaac ggagagctgt 115261 cgggctgaca acaacagtgg caaaagcttc aacaggagca attgagcaca ttcctgtagc 115321 aagagtcacc aatttggcac ggacgttaga agagatgaaa gagcggggaa tctgggttgt 115381 cggaacggat gcgtccgcgc gtgaggattt ccgtaatatg gacggcaata tgcctttggc 115441 tctagtcatc ggaagtgaag gaaaagggat gggccgcctt gtgaaggaaa agtgcgattt 115501 tctcattaaa ctcccgatgg ccggaaaggt aacttcacta aatgcatctg tcgcggctgg 115561 tcttttgatg tatgaagtct accggaaacg aaaccctgtg ggagaataaa gacccatgga 115621 tatcctgtta gtagacgggt acaacatgat tggagcctgg ccgcagctga aggatttaaa 115681 agcgaacagt tttgaagagg cgagagacgt actgattcag aaaatggcgg aatatcaatc 115741 gtatacagga aacagggtta ttgttgtttt tgacgcgcat ctcgtaaaag ggcttgagaa 115801 aaaacagacc aaccatagag ttgaagtaat ttttacaaaa gaaaatgaga cggctgatga 115861 gcggatagaa aagctcgctc aggctttgaa taatattgcg actcaaattc acgttgcgac 115921 ctctgactat actgagcagt gggcgatttt cggacagggg gcattgcgga aatcggcccg 115981 ggagcttctg agagaggtag aaacgattga aaggcgaata gagagacggg taagaaaaat 116041 cacttccgaa aagccggcgg gtaaaattgc tttatcggaa gaggttttga aaacgtttga 116101 aaagtggagg cggggagact tagattaagt tgacgctttt ttgcccaata ctgtataata 116161 tttctatcta cgtgcgccgg ggggatcgga gtgaatctac agaacaacaa gggaaaattc 116221 aacaaagagc agttttgcca gttggaggac gagcaggtca ttgaaaaggt tcatgttggg 116281 gacagtgatg cgttagatta cttgattacg aagtaccgaa actttgttcg ggcaaaagca 116341 agatcctatt tcttaatagg ggcggacaga gaggatattg ttcaggaagg catgataggc 116401 ctctataagt ctattcgtga cttcaaagag gacaagctta cctcattcaa agcttttgca 116461 gaattatgta ttacccgcca aattattacc gcaataaaga cagctactcg ccagaaacac 116521 attcctttga attcctacgc ctcattagat aaaccgatct ttgatgaaga atcagaccga 116581 acgctgctgg atgtcatttc aggagcgaaa accttaaatc ctgaggaaat gatcattaat 116641 caggaagaat ttgatgatat tgaaatgaaa atgggagaac tattaagtga tttagagaga 116701 aaagtactcg tcttatatct cgacgggaga agttaccaag agatttctga tgaactgaac 116761 cgacatgtga aatcgatcga caatgccctt cagcgtgtga aacgcaagct ggagaagtac 116821 ttggaaattc gcgaaatcag tttgtaatag gaatttatgc tatattgaca gtatttttct 116881 gactatgata tgttactaaa gataagaact aatgtctatt tagaaaaagg tgtaatgaca 116941 tgagaaaaaa gattacgtta gcatgcaaga catgcggaaa ccgtaattat acgacaatga 117001 agagctctgc atcagcggct gagcgattag aagtaaagaa atactgcagt acttgcaatt 117061 cacatacagc tcatcttgaa acaaaatagt ttttgcgctt ttaaattgtg gaggtctttt 117121 acatgcgtat tatgaaattc tttaaagatg ttgggaaaga aatgaaaaag gtaagctggc 117181 ctaaaggaaa agagttaacg cgttatacca ttacggtaat ttcaacagtt atcttttttg 117241 ttatcttttt tgccctcctt gacacaggaa tttctcaatt aattcgttta atagttgaat 117301 aatgatcagc aatacgtgct ataatagatc ataatattac ttgccaaaac ccgttcagcg 117361 ggttttttat tgtggcttaa aatgaaagtt atcataggct tgccgcctat tttttgaagc 117421 gttatggtaa ttcactaaaa ccaaatgcgg ggagggaagg actggacagt cctgaataga 117481 atggaaaaga attggtatgt tgttcacacg tactctggtt atgagaataa agtaaaagcc 117541 aacttggaaa agcgtgttga atcaatgggg atgcaggata aaattttccg tgtagtcgta 117601 cccgaagaag aagaaacgga tatcaaaaac ggcaagaaaa aagtcgtgaa aaagaaagta 117661 ttccctggtt atgtgcttgt tgaaattgta atgacagacg actcttggta tgtcgtccgc 117721 aacacgccgg gcgttactgg attcgtagga tctgccgggt caggttcaaa accgacgccg 117781 cttcttccgg gggaagcaga aaccattctg aagagaatgg gcatggatga acgaaaaact 117841 gatattgact ttgaactgaa agagacagtg aaagtaatag acggaccttt tgctaacttt 117901 acaggatcaa ttgaagagat tgattatgat aaaagcaagg tcaaagtttt cgttaatatg 117961 tttggccgtg aaacgccggt tgagctggaa tttacccaaa tcgataaatt gtaatgtgaa 118021 aaaacttgaa attgctatat ataaatgata atatagcaaa ggtacgtctt ggacttatcc 118081 aaggcaacta gcatgatatt tcgtcattca tataaagaat gaaaccttga gtgggagggt 118141 ttaccctatt accacatcac ggacttaagg aggtgtgtct cgtggctaaa aaagtagtta 118201 aagttgtaaa attgcaaatt cctgctggaa aagctaaccc agcaccacca gttggacctg 118261 cacttggtca agccggtgtt aacatcatgg gattctgtaa ggagtttaac gctcgtacag 118321 ctgaccaagc tggtttaatc attcctgttg aaatttcggt ttacgaagac cgttcattta 118381 catttattac aaaaactcca cctgctgcag tattgcttaa aaaagcagct ggaattgagt 118441 ctggttctgg tgaaccaaac cgtaataaag tggcaaccgt taagcgcgat aaagtacgcg 118501 aaatcgctga aacgaaaatg cctgacttaa acgcagcaga cgttgaagcg gcaatgcgca 118561 tggttgaagg tactgcccgc agtatgggta ttgtaatcga ggattaattt gtttcttgtc 118621 gggttgcgag ttttaacaag ttcgcaaccc ttattcgtgg gaggttattc cgctataacc 118681 acataaggag gaaattttaa aatggctaaa aaaggtaaaa agtacgttga agctgctaag 118741 cttgtagacc gttctaaagc ttacgacgtc tctgaagcag tagctctcgt taaaaaaaca 118801 aacacagcta aattcgacgc tacagttgaa gtggctttcc gtttaggggt tgaccctcgt 118861 aaaaacgacc agcaaatccg tggagcagtt gtgcttccaa acggaactgg taaaactcag 118921 cgcgttctcg ttttcgcaaa aggcgaaaaa gcgaaagaag ctgaagctgc tggtgcagat 118981 ttcgtaggcg atactgacta catcaacaaa attcaacaag gctggttcga tttcgatgtt 119041 atcgtagcta cacctgacat gatgggtgaa gttggtaaaa tcggtcgtgt acttggacca 119101 aaaggtttaa tgccgaaccc taaaactggt acagttactt tcgaagttga aaaagctatc 119161 ggcgaaatca aagctggtaa agttgaatac cgcgttgata aagctggaaa cattcatgtt 119221 cctatcggta aagtttcttt cgaggatgaa aaacttgttg agaacttcac aacaatgtac 119281 gatacaatcc ttaaagctaa acctgctgca gctaaaggcg tttacgtgaa aaacgttgct 119341 gtaacttcta ctatgggacc tggtgtcaaa gtagactctt caacttttaa cgtaaaataa 119401 tattgacatg acatcaacat tctgatatta ttcaaaatgt tgtaaaatag aatatcattt 119461 ataccgtaga cagtaggggc ctaaccgctt aattatccta ccgaggtgta tattatcaca 119521 gctattacgt tacgtatgct tgtatataca gcctccatgt ctcatggagg ctttttatat 119581 ggaatccgtc gtctcagtcg tgatcaccta acggtataag tgttacacaa gaatctacag 119641 gaggtgtaac catgagcagc gcaattgaaa caaaaaaagt tgttgttgaa gaaattgctt 119701 ctaaactgaa agaaagtaaa tcaacgatca tcgttgacta tcgcggactt aacgtttctg 119761 aagtaactga acttcgtaaa cagcttcgcg aagctaacgt tgagttcaaa gtttacaaaa 119821 atacgatgac tcgccgtgcg gttgaacaag ctgagcttaa tggtttgaat gatttcttaa 119881 ctggaccgaa cgcgatcgca ttcagcactg aagatgttgt cgctccggct aaagttctta 119941 atgacttcgc taaaaatcac gaagctcttg aaatcaaagc tggcgttatc gaaggtaaag 120001 tttctactgt tgaagaagtg aaagctcttg ctgaacttcc atcacgcgaa ggcttgcttt 120061 ctatgttgct tagcgtactt caagctccag ttcgcaacct tgctcttgct gcaaaagctg 120121 tggcagaaca aaaggaagaa caaggcgctt aatctaatca gtttttcata aattaaaaca 120181 aaatggagga attacaaatg gctttaaata tcgaagaaat cattgcttcc gttaaagaag 120241 caactgtact tgaattgaac gacctagtaa aagcaatcga agaagaattt ggcgtaactg 120301 ctgctgctcc tgtagctgta gctggcggag ctgctgctgg cggagctgct gaagagcaaa 120361 gcgaattcga tcttatcctt gctggtgcag gatctcaaaa aatcaaagtt atcaaagttg 120421 tacgtgaaat cactggtctt ggcttgaaag aagctaaaga gcttgttgac aacactccaa 120481 aaccacttaa agaaggtatt gctaaagaag aagctgaaga gcttaaagct aaacttgaag 120541 aagttggcgc ttctgtagaa gttaagtaat cttcacttac ctgtagggga agctcgcttt 120601 tatgaggcga gctttttctt tgccattctt taagccatga aaaaaggagg ttctaataat 120661 gagtgagcac tattattcag aaaaaccttc agtaaaaagc aacaagcaaa cctggtcttt 120721 taggcttcgg aataaagatt tcacgtttac cagcgacagc ggggtttttt ctaaaaaaga 120781 agttgatttc ggctcccgcc tgctgattga ttcttttgaa gagcctgagg ttgagggcgg 120841 cattttagat gtaggctgcg gatacggccc gattggttta tcgctcgcca gcgactttaa 120901 agaccggacc atccacatga ttgacgttaa tgagagagcc gtagaactat caaatgaaaa 120961 tgcggaacag aacggaataa caaacgttaa gatttatcaa agcgatttgt tttcaaacgt 121021 tgattctgct caaacatttg cttctattct tacaaatccc ccaatccgag ccggaaaaaa 121081 agttgtccat gctatctttg agaaaagcgc tgaacactta aaagcttcag gtgaattgtg 121141 gatcgtcata cagaaaaagc aaggcgcgcc ttctgccatt gaaaagctcg aggaactgtt 121201 cgatgaagtt tccgtcgttc aaaaaaagaa aggctattat atcataaaag caaaaaaagt 121261 ttgactcggt attttaacta tgttaatatt gtaaaatgcc aatgtatata ttttgcttga 121321 tatgatgaat tgtcaatatc tatgtataaa ttatacaagt atggaaatgc taataaaatc 121381 ggtatttgtt tttggatgtg gttttcttaa ttagaaaccc ttttttcttt tgtcttgtaa 121441 aagtattttc tttctttgga agaaatgctt attacacata taatacgcat gatttgaggg 121501 gtgaatcagt tgacaggtca actagttcag tatggacgac accgccagcg cagaagctat 121561 gctcgcatta gcgaagtgtt agaattacca aatctcattg aaattcaaac ctcttcttat 121621 cagtggtttc ttgatgaggg tcttagagag atgtttcaag acatatcacc aattgaggat 121681 ttcactggta acctctctct tgagttcatt gattatagtt taggtgagcc taaatatcct 121741 gtagaggaat caaaagaacg tgatgtgact tactcagctc cgctaagagt gaaggttcgt 121801 ttaattaaca aagaaactgg agaggtaaaa gaccaagatg tcttcatggg tgatttccct 121861 attatgacag atacaggtac ttttatcatt aacggtgcgg aacgtgttat cgtttcccag 121921 cttgttcggt ctccaagtgt atatttcagt ggtaaagtag acaaaaacgg taaaaaaggt 121981 tttaccgcaa ctgtcattcc aaaccgtggc gcatggttag aatacgaaac tgatgcgaaa 122041 gatgttgttt atgtccgcat tgatcgcaca cgtaagttgc cggttacggt tcttttgcgt 122101 gctctcggct tcggctccga tcaagagatt cttgatctca taggagaaaa cgaatacctg 122161 cgaaatacgc ttgataaaga taacacagaa aacagcgaca aagcgttgct ggaaatttac 122221 gagcgtctcc gtcctggaga gccgcctaca gtagaaaatg cgaaaagctt gcttgattct 122281 cgtttctttg atccgaaacg atacgatctt gccaatgtag gacgctataa aattaataaa 122341 aaacttcata ttaagaatcg cctcttcaat cagagacttg ctgaaacgct tgttgatcct 122401 gaaacaggag aaatccttgc tgaaaaaggc cagattcttg atagaagaac gcttgataaa 122461 gtactgccat acttagaaaa cggaatcggt tttagaaagc tgtatccgaa tggcggcgtt 122521 gttgaagatg aagtgactct tcaatcaatt aaaatctttg ctccgactga tcaagaagga 122581 gaacaggtta tcaatgtaat cggcaatgct tacatcgaag aagagattaa aaacatcacg 122641 cctgctgata ttatttcttc aatcagctac ttcttcaacc tgctgcacgg agtaggcgac 122701 acagatgata tcgatcatct tggaaaccgc cgtttacgtt ctgtaggcga gcttctccag 122761 aaccaattcc gtatcggttt aagccgtatg gagcgtgtgg ttcgtgagag aatgtcaatt 122821 caagatacga atacaattac gcctcagcag ctgatcaata ttcgtcctgt tattgcgtcc 122881 attaaagagt tctttggaag ctcacagctt tctcaattca tggatcagac gaacccgctt 122941 gctgaattaa cgcacaagcg tcgtctgtca gcattaggac cgggcggatt gacacgtgag 123001 cgtgccggaa tggaagtgcg tgacgttcac tactcccact atggccgtat gtgtccgatt 123061 gaaacgcctg agggcccgaa catcggtttg atcaactcac tatcatctta tgcaaaagta 123121 aaccgttttg gctttattga aacgccatat cgccgcgttg accctgaaac agggaaggta 123181 acgggcagaa tcgattactt aactgctgat gaagaggata actatgttgt cgctcaagcg 123241 aatgctcgtc ttgatgacga aggcgccttt attgatgaca gcatcgtagc tcgtttccgc 123301 ggggagaaca ccgttgtttc cagaaatcgt gtagactaca tggatgtatc gcctaagcag 123361 gttgtatctg ctgcgacagc atgtatcccg ttcttagaaa acgatgactc caaccgtgcc 123421 ctcatgggag cgaacatgca gcgtcaggct gtgcctttga tgcagccgga agcgccattt 123481 gttggaactg gtatggaata cgtatcagga aaagactctg gtgccgctgt tatttgtaaa 123541 caccctggta tcgttgaacg cgtagaagcc aaaaacgttt gggttcgccg ttatgaagaa 123601 gtagacggtc aaaaagtaaa aggaaacctg gataaataca gcctgctgaa atttgtccgc 123661 tctaaccaag gtacgtgcta caaccagcgt ccgatcgtaa gtgtcggcga tgaagtggta 123721 aaaggagaaa tccttgctga cggtccttct atggagcttg gtgaacttgc acttggccgt 123781 aacgtaatgg tcggcttcat gacgtgggat ggctacaact atgaggatgc catcatcatg 123841 agtgaacgcc tagtgaagga tgatgtttat acatctatcc acattgaaga atacgaatca 123901 gaagcacgtg atacgaaact tggacctgaa gaaatcactc gcgatattcc aaacgtcggt 123961 gaagatgcgc ttcgcaatct tgatgaccgc ggaatcatcc gtattggggc agaagtaaaa 124021 gacggagatc ttcttgttgg taaagtaacg cctaaaggcg taactgaact gactgccgaa 124081 gaacgccttc ttcacgccat ctttggcgag aaagcccgcg aggttcgtga tacttctctt 124141 cgtgtgcctc atggcggcgg cggaattatc catgacgtta aagtcttcaa ccgtgaagac 124201 ggagacgaac ttcctccagg tgttaaccag ttagtacgcg tatatatcgt tcagaaacgt 124261 aagatttctg aaggggataa aatggccggt cgtcacggta acaaaggtgt tatctctaag 124321 attcttcctg aagaggatat gccttacctt cctgacggca caccaattga tatcatgctt 124381 aacccgctgg gcgtaccatc acgtatgaac atcgggcagg tattggaact tcacatgggt 124441 atggccgctc gttaccttgg cattcacatt gcatctcctg tatttgacgg agcgcgagaa 124501 gaggatgtct gggaaacact tgaagaagcc ggcatgtctc gtgacgccaa aacagtgctt 124561 tacgacggac gtactggaga gccgtttgat aaccgtgtat ctgtcggtat catgtacatg 124621 atcaaactgg ctcacatggt tgacgataaa cttcatgcac gctctacagg cccttactca 124681 cttgttacgc agcagcctct tggcggtaaa gcgcaatttg gcggacagcg ttttggtgag 124741 atggaggttt gggcacttga agcttacggt gcggcttaca ctcttcaaga aattctgact 124801 gttaagtctg atgacgtggt tggacgtgtg aaaacatacg aagccatcgt taaaggcgac 124861 aatgttcctg aaccaggtgt tccggaatca ttcaaagtat taatcaaaga acttcaaagc 124921 ttaggtatgg atgtcaaaat cctttctggt gatgaagaag aaatagaaat gagagattta 124981 gaagacgaag aagatgcgaa acaagctgac ggcctggcat tatcaggtga tgaagagccg 125041 gaagaaacag catctgcaga cgttgaacgc gatgtagtaa caaaagaata atctctagtt 125101 ataaaggcaa gtgacatcgg ttaatccgaa gataaaaagg gaggtaggcc ccttgctaga 125161 tgtgaacaat tttgagtata tgaacatcgg tcttgcttca ccagataaaa tccgttcatg 125221 gtcttttggt gaagtgaaaa agcctgaaac gataaactat cgtacgttaa aacctgaaaa 125281 ggacggtcta ttctgcgaac gcattttcgg accgactaag gactgggaat gtcattgcgg 125341 gaagtacaag cgagttcgtt ataaaggcgt agtttgtgac cgctgcggag tcgaagtaac 125401 acgggctaaa gtccgtcgtg agagaatggg gcacattgaa ctggctgccc cagtttccca 125461 catttggtat ttcaaaggta ttccaagccg tatgggtctt gtgctggata tgtcacctcg 125521 tgctttagaa gaagtcattt actttgcttc ttacgttgta actgatccgg cgaatacacc 125581 gcttgaaaag aaacagcttc tgtctgagaa agaataccgt gcttatcttg ataaatacgg 125641 taataaattc caagcatcta tgggtgctga agcaattcat aaacttcttc aagatatcga 125701 tcttgtaaaa gaagttgata tgttaaaaga agagctgaaa acttcacaag gacaacgccg 125761 tactcgtgcg atcaaacgtc ttgaagtttt agaagccttc cgtaactcag gaaacaagcc 125821 ttcttggatg atccttgatg tgcttcctgt tattcctccg gagcttagac cgatggttca 125881 gctagatggc ggacgttttg cgacttctga tttgaatgac ctttatcgtc gtgtcatcaa 125941 ccgtaacaat cgtttgaaac gccttttgga ccttggtgcg cctagcatca tcgttcaaaa 126001 cgaaaagcgt atgcttcaag aggctgtcga tgccctaatt gacaacggcc gccgcggacg 126061 ccctgtaaca ggtcctggaa acagaccgtt aaaatctctt tctcacatgc tgaaagggaa 126121 gcaaggccgt ttccgtcaaa accttcttgg taaacgtgtc gattactccg gacgttctgt 126181 aatcgttgtt ggtcctcatt tgaaaatgta ccaatgcgga ttaccgaagg aaatggcact 126241 tgaacttttc aaacctttcg ttatgaaaga acttgttgaa aaaggtcttg ctcacaacat 126301 taagagtgcg aaacgcaaaa ttgagcgcgt acagcctgaa gtttgggatg tactagaatc 126361 agttattaag gagcatccgg tactgctgaa ccgtgcccct acacttcaca gattaggtat 126421 ccaggcgttt gaaccaacgc ttgttgaagg acgcgcaatc cgtcttcacc cgctcgtatg 126481 tacagcttac aacgctgact ttgacggtga ccaaatggcg gttcacgtac cattatctgc 126541 tgaagcacaa gctgaagcac gcatcttgat gcttgctgct caaaacatct tgaaccctaa 126601 agatggtaaa ccggttgtaa caccgtctca ggatatggta ctaggtaact attacctgac 126661 acttgagcgt gccggtgctg tcggtgaagg tatggtcttc aagaatacag acgaagcgct 126721 tcttgcttat caaaacggat atgttcacct tcatacgaga gtagctgttg cagctaactc 126781 acttaagaat gtgacattta ccgaagaaca gcgctcaaaa ttgttaatta caactgtcgg 126841 taagcttgtc ttcaatgaaa ttcttccgga atcattccct tacatgaatg aaccaacgaa 126901 gagcaacatt gaagagaaaa cacctgaccg tttcttctta gaaaaaggtg ctgatgttaa 126961 agctgttatc gcacagcagc caatcaatgc gccgtttaaa aaaggcattc tgggtaaaat 127021 catcgcggaa atctttaaac gattccatat tacggaaacg tctaaaatgc ttgaccgcat 127081 gaaaaaccta ggtttcaaat attcaactaa agctggtatt acagttgggg tttctgacat 127141 cgtcgtactc gatgataaac aagaaattct tgaggaagcg caaagcaaag ttgacaacgt 127201 tatgaagcaa ttccgccgcg gtcttatcac tgaagaagaa cgctatgaga gagtcatctc 127261 tatctggagt gctgcaaaag acgttatcca aggcaaactg atgaaatcac ttgatgaact 127321 caacccgatc tacatgatga gtgactctgg tgcccgtggt aacgcatcta actttacgca 127381 gcttgccgga atgcgcggcc tgatggccaa cccggctgga cgtatcattg agttgccgat 127441 caaatcaagt ttccgtgaag gtctgacagt attggagtac tttatctcca cacacggtgc 127501 gcgtaaaggt cttgccgata ccgctcttaa aactgctgac tcaggttacc ttacacgccg 127561 tctcgttgac gttgctcagg atgttatcat ccgtgaaact gattgcggaa ctgaccgagg 127621 cattcttgct aagcctctta aagaaggaac tgaaacaatt gagcgcttag aagaacgctt 127681 aatcggacgt tttgcaagaa aacaagtgaa gcaccctgaa acaggtgaag tgcttgtgaa 127741 tgaaaacgaa ctgatcgatg aagataaagc actggagatt gtcgaagccg gcattgaaga 127801 agtgtggatc cgttctgcct tcacatgtaa tacgcctcat ggtgtatgta aacgatgcta 127861 tggccgaaat cttgcaactg gctccgatgt tgaagtcggt gaagctgtcg gaatcattgc 127921 tgcccaatca atcggtgagc ctggtacaca gttaacaatg cgtacattcc atacaggcgg 127981 ggttgccgga gacgatatca cacagggtct tccgcgtatc caagagcttt tcgaagcgcg 128041 taatccgaaa ggtcaggcaa caattacaga aatcgacggt acagtcgttg agatcaatga 128101 agttcgtgat aagcaacagg aaattgtggt tcaaggcgca gtggaaacac gttcttatac 128161 ggcaccttac aactcccgcc tgaaagtagc ggaaggagat aaaattactc gaggccaagt 128221 actgacagaa ggttcaatcg atccgaaaga acttcttaaa gtgactgacc tgacgactgt 128281 tcaagagtat cttctccatg aggttcaaaa ggtttaccgt atgcagggtg ttgaaatcgg 128341 tgataaacac gtagaagtaa tggttcgcca gatgcttcgc aaagtacgcg tgattgatgc 128401 cggtgacact gatgtgcttc caggtacatt gcttgatatt caccaattta ctgaagcgaa 128461 caaaaaggta ttgcttgaag gcaaccgacc agctacaggc cgtcctgtct tactcggtat 128521 tacaaaagca tctcttgaaa ctgattcatt cttatctgct gcttccttcc aggaaacaac 128581 acgtgtcctt acagatgcag cgatcaaagg taagcgtgac gagcttctcg gcttgaaaga 128641 gaatgttatc atcggtaagc ttgttccagc aggtacagga atgatgaaat accgtaaagt 128701 aaaaccagta tcaaatgttc agccgactga cgatatggtc ccggttgaat aactgattta 128761 actctgctga aagactgcaa aaacagtctt tcagcagata tatttatgaa aaagtcactc 128821 tatgagaaga acgaatctaa aaaatgtcat accttgttga cattcgtctc ctagaatgat 128881 aatataacca aggtgctcga aataaacctg ttactttgga ggatatgttt atgtcttatg 128941 ataaagtatc acaggccaaa tcaattatta ttggtacgaa gcaaacagtg aaagctctaa 129001 agcgaggttc agtaaaggaa gtagtcgttg caaaagacgc agatccgata ctcacgtcaa 129061 gtgttgtttc acttgctgaa gatcaaggta tctctgtctc aatggttgaa tccatgaaaa 129121 agctcggcaa agcctgcgga attgaggtag gagcagccgc tgttgccatt attttataac 129181 gtacttttgt ttttgcgtaa gattccatct tgtgtaaaga cattgttttt tgccttttga 129241 tgaaccacct gggtatgtgg gttataaaac gtaatgaagg gaggaaaaat tcatgcctac 129301 aattaatcag ctaattcgca aaggacgcgt gagtaaagta gaaaactcaa agtctcctgc 129361 acttaacaaa ggatacaaca gctttaaaaa agagcacact aacgtatctt ctccacaaaa 129421 acgcggggta tgtactcgtg ttggtacaat gacaccgaaa aaaccgaact cagcacttcg 129481 taaatatgct cgtgttcgtt tgactaacgg aatcgaggtt actgcttaca ttcctggtat 129541 cggtcacaac ctgcaagagc acagtgttgt acttatccgc ggcggacgtg taaaagactt 129601 accaggggta cgttaccaca tcgttcgtgg tgcgcttgat actgctggag ttgaaaaccg 129661 tgcacaaggc cgttctaaat acggtacgaa aaaacctaaa gcaaaataat atacgaaaat 129721 acgcataatt gatgaaggga ggatattcag atgccacgta aaggtcctgt agcaaaaaga 129781 gatgttttac ctgatccgat ttacaactct aagcttgtat ctcgtttaat caacaaaatg 129841 atgatcgatg gtaaaaaagg taagtctcaa acgatcctat acaagtcatt cgatatcatt 129901 aaagaacgta ctggcaatga tgcaatggag gttttcgaac aagcattgaa aaacatcatg 129961 cctgtacttg aagtaaaagc acgccgtgta ggtggtgcga actaccaagt tcctgtagaa 130021 gttcgtcctg aacgtcgtac gactcttgga cttcgctggt tagttaacta cgctcgtctt 130081 cgtggagaaa aaacgatgga agagcgttta gctaacgaaa tccttgacgc agctaacaac 130141 actggtgctg ctgttaagaa acgtgaagac actcataaga tggctgaagc aaacaaagca 130201 tttgctcact atcgctggta ggatttatag attaacaaaa cacaatttcc taataaggaa 130261 ggagaaatta cccaatggca agagagttct ccttagaaaa aactcgtaat atcggtatca 130321 tggctcacat cgatgccggt aaaacgacta ctacagaacg tatcttgttc tatactggtc 130381 gtatccacaa aattggtgaa actcatgaag gagcttcaca aatggactgg atggagcagg 130441 aacaagaacg tggtatcaca atcacttccg ctgcgactac tgcacagtgg aaaggatacc 130501 gcgtaaacat catcgatact ccaggacacg tagacttcac agttgaagtt gaacgttctc 130561 ttcgtgtact tgatggtgct gttgctgtac ttgacgcgca atcaggcgtt gagcctcaaa 130621 cagaaactgt ttggcgtcag gcaacaactt atggagtacc gcgtatcgtt tttgttaaca 130681 aaatggacaa aatcggtgca gacttccttt actctgtagg aactttaaga gaccgtcttc 130741 aagcaaacgc tcatgcaatt caattgccga tcggtgctga agataacttc gaaggtatca 130801 ttgaccttgt agaaaacgtt gcgtatttct acgaagatga cctcggaact cgttctgatg 130861 caaaagaaat ccctgaagag tacaaagagc aagctgaaga gcttcgcaac agccttattg 130921 aagctgtatg tgagcttgat gaagagctta tggataagta ccttgagggt gaagaaatca 130981 caattgacga gttaaaagca ggaattcgta aaggtacatt aaatgttgaa ttctaccctg 131041 ttcttgttgg ttctgccttc aaaaacaaag gtgttcaact agtacttgat gctgttcttg 131101 actaccttcc tgcaccaact gacgttgctg caatcaaagg tacacgtcct gatacaaatg 131161 aagagattga gcgtcattct tctgacgaag agccattctc tgcattagca tttaaagtta 131221 tgactgaccc ttacgttggt aagttgacgt tcttccgtgt gtactctgga acacttgatt 131281 ctggttcata cgtgaaaaac tctactaaag gcaaacgtga gcgtgttgga cgtattcttc 131341 aaatgcacgc taacagccgt gaagaaatct ctactgtata cgcaggggat atcgcagctg 131401 ctgtaggtct aaaagataca actactggag atactctatg tgatgagaag gatcttgtta 131461 tccttgagtc aatggaattc ccagaaccag ttatcgacgt tgctattgag cctaaatcaa 131521 aagctgacca agataaaatg ggtatcgctt tagcgaaact tgctgaagaa gatcctacat 131581 tccgtactca aacaaaccca gaaactggcc aaacgatcat ctctggtatg ggtgaacttc 131641 accttgatat cattgttgac cgtatgaaac gcgaatttaa agtagaagcc aatgttggtg 131701 ctcctcaagt tgcgtaccgt gaaacattcc gtaccggtgc aaaagttgaa ggtaaattcg 131761 tacgtcagtc tggtggacgc ggtcagttcg gacacgtttg gatcgaattc gaaccaaacg 131821 aagaaggcgc tggctttgaa tttgaaaatg cgattgtcgg tggggtcgtt cctcgtgaat 131881 acatcccagc tgttcaagca ggtctggaag atgcactcga aaatggtgta ctagcaggct 131941 tcccgcttat cgacattaaa gctaaacttt tcgacggttc ttaccatgat gttgactcaa 132001 acgaaatggc atttaaagtc gctgcttcta tggcattgaa aaatgcagtc agcaaatgta 132061 acccagttct tcttgaacca atcatgaaag tggaagtggt tattccagaa gaatatatgg 132121 gagatatcat gggtgatatc acttcacgtc gcggacgcgt agaaggtatg gaagcacgcg 132181 gtaacgctca agttgttcgt gctatggttc ctcttgctga aatgttcggt tacgctactg 132241 cacttcgttc taatacgcaa ggtcgcggta cgttcactat gcacatggat cactacgaag 132301 aagtgccgaa gagcgtcgca gaagaaatta tcaaaaaaaa taaaggcgaa taattgattt 132361 tgccgcttaa ctcaagtata actactattg taagatgagg aagtgaaagc tttctttcac 132421 ttcctatcac tctatacatt actaattaaa agctcttaag gaggatttta gaatggctaa 132481 agaaaaattc gaccgttcca aatcacatgc caatattggt acaattggac acgttgacca 132541 tggtaaaaca actttaactg ctgctatcac aacagtactt cataagaaat ctggtaaagg 132601 tacagctatg gcgtacgatc aaattgatgg tgctccagaa gaacgcgagc gcggtatcac 132661 aatctctact gcacacgttg agtacgaaac tgaaactcgt cactatgcac acgttgactg 132721 cccaggacac gctgactatg ttaaaaacat gatcactggt gctgcgcaaa tggacggagc 132781 tatccttgta gtatctgctg ctgatggccc aatgccacaa actcgtgagc acatccttct 132841 ttctaaaaac gttggtgtac catacatcgt tgtattctta aacaaatgcg acatggtaga 132901 cgacgaagag cttcttgaac tagttgaaat ggaagttcgc gatcttctta gcgaatacga 132961 cttccctggt gatgatgtac cagttgttaa aggttctgct cttaaagctc ttgaaggaga 133021 cgctgagtgg gaagctaaaa tcttcgaact tatggatgcg gttgatgagt acatcccaac 133081 tccagaacgc gacactgaaa aaccattcat gatgccagtt gaggacgtat tctcaatcac 133141 tggtcgtggt acagttgcta ctggccgtgt agaacgcgga caagttaaag tcggtgacga 133201 agttgaaatc atcggtcttc aagaagagaa caagaaaaca actgttacag gtgttgaaat 133261 gttccgtaag cttcttgatt acgctgaagc tggtgacaac attggtgccc ttcttcgcgg 133321 tgtatctcgt gaagaaatcc aacgtggtca agtacttgct aaaccaggta caatcactcc 133381 acacagcaaa ttcaaagctg aagtttacgt tctttctaaa gaagagggtg gacgtcatac 133441 tccattcttc tctaactacc gtcctcagtt ctacttccgt acaactgacg taactggtat 133501 catccatctt ccagaaggcg tagaaatggt tatgcctgga gataacactg aaatgaacgt 133561 tgaacttatt tctacaatcg ctatcgaaga aggaactcgt ttctctattc gtgaaggcgg 133621 acgtactgtt ggttcaggcg ttgtttctac aatcactgag taatagtatg gttttaaacg 133681 agacccctgt gggtctcgtt ttttgtttgc ttatcttttt cttgtataat aggatctatc 133741 atattcgagg ggttaatatt tatgattcct gaaaagaaat caatcgcaat catgaaagaa 133801 ctaagcattg gaaatacaaa gcaaatgctg atgattaatg gagttgacgt gaaaaatcca 133861 ttgctgcttt ttttacatgg cgggccggga acgccgcaaa tcggatatgt tagacattat 133921 caaaaagagc tggaacagta ttttacagta gttcattggg atcagagagg atcggggctt 133981 tcttattcta agcgaatttc gcatcactct atgacaataa atcacttcat taaagataca 134041 atccaagtca ctcaatggct tttagctcat ttttcaaaat caaaacttta cctagccggt 134101 cattcttggg gatcaatact ggcgcttcat gtgctgcagc agcgtcctga tttattttac 134161 acgtattatg gaatcagcca ggttgttaac ccgcaagatg aagaatcaac tgcttatcaa 134221 catattcgtg aaatttccga atcaaaaaaa gccagcatat tatctttcct tacacgtttc 134281 attggtgctc cgccttggaa gcaggatatc cagcacctta tctatcggtt ttgtgttgag 134341 ctaaccaggg gaggattcac tcaccgtcat cgtcaatctc tcgctgtatt atttcaaatg 134401 cttactggca atgagtatgg agtgcggaac atgcacagct tccttaatgg attgcgcttc 134461 agtaaaaaac atttaactga tgagttgtac cggtttaatg cttttacatc agttccttct 134521 attaaagtac cgtgtgtttt catttcaggg aaacatgact taattgttcc tgcagaaata 134581 tcgaaacagt attatcaaga acttgaggca cctgaaaagc gctggtttca atttgagaat 134641 tcagctcaca ccccgcatat tgaggagcca tcattattcg cgaacacatt aagtcggcat 134701 gcacgacacc atttatgata gatccttgat aaataagaaa aacccctgta taataaaaaa 134761 agtgtgcaaa tcatgcatat tttaaataag tcttgcaaca tgcgcctatt ttctgtataa 134821 tggtgtatgt tggtctttga ctgcgatgaa gtgagaggtt gctgacacac ccggccgctt 134881 tgccatggca aggtgttcag gtttttctca cggagaactg tctaacgtga tgtaggcgaa 134941 aaggagggaa aataatggca aaacaaaaaa ttcgtattcg tttgaaagca tatgatcata 135001 gaatccttga tcaatctgca gagaagattg ttgaaacggc aaaacgttct ggtgccagcg 135061 tatctggtcc gattccgttg ccaactgaaa aatcagttta cacaatcctt cgtgcggtgc 135121 acaaatacaa agattctcgt gagcaatttg aaatgcgtac acataaacgt ttaatcgaca 135181 ttgtgaaccc aacaccacaa actgttgatg ctcttatgcg attagactta ccatctggtg 135241 tcgatatcga aattaaactt taattctaaa atatagaatg atcttaatag gaggtgtgac 135301 gaatgaccaa aggaatctta ggaagaaaaa ttggtatgac gcaagtattc gctgagaatg 135361 gtgatcttat tccggtaact gttatcgagg ctgctccaaa cgttgttctt caaaagaaaa 135421 cagctgaaaa cgacggttac gaagcaatcc agcttggttt tgacgacaag cgtgaaaagc 135481 tttctaacaa acctgaaaaa gggcacgttg caaaagcgga aactgctcct aagcgcttcg 135541 ttaaagaatt acgcggagtg gaaatggatg cgtatgaagt tggtcaggaa gtcaaggttg 135601 aaattttctc tgctggagaa atcgtagatg taacaggagt atctaaaggt aaaggtttcc 135661 aaggtgcgat caagcgccac ggacaatctc gcggacctat gtctcacggt tcacgctacc 135721 accgtcgtcc tggttcaatg ggacctgtag atcctaaccg tgtattcaaa ggtaaattat 135781 tacctggacg tatgggcgga gagcaaatca ctgttcaaaa ccttgaaatc gtaaaagttg 135841 atgcagaacg caatcttctt ttgatcaaag gtaacgtacc tggtgcgaag aaatctttaa 135901 tcactgttaa aagtgctgtt aaatctaaat aattctctta ggaaaggagg aaattgatta 135961 tgccaaaagt agcattatac aaccaaaacg gttctactgc tggtgacatc gaattaaacg 136021 cttctgtatt tggtatcgaa ccaaatgaga gtgttgtatt cgacgctatt cttatgcaaa 136081 gagcttcctt acgtcaagga actcacaaag taaaaaatcg ttctgaagta cgcggcggag 136141 gtcgtaaacc atggcgtcaa aaaggtactg gacgtgcccg tcaaggttca atccgttcac 136201 cgcaatggcg cggaggtggt gtcgtattcg gcccaacacc acgcagctat tcttataaat 136261 tacctaaaaa agttcgccgc ttggcaatca aatcagtatt gtcttctaaa gtgatcgaca 136321 acaacatcat cgttcttgaa gatcttactc ttgatacggc taaaacaaaa gaaatggcag 136381 ctatccttaa aggattatct gttgagaaaa aagctttaat cgtaactgcg gatgcaaacg 136441 aagcagtagc attatctgct cgtaacattc ctggagttac tgttgttgaa gctaacggaa 136501 tcaacgtttt agacgttgtc aaccacgaga agcttctgat tacaaaagca gcggttgaaa 136561 aagtagagga ggtgcttgca taatgaaaga tcctcgtgat gttctaaagc gccccgtcat 136621 tactgaacgt tctgccgatt taatgactga aaaaaaatat acttttgaag ttgatgtaag 136681 agctaacaaa acagaagtga aagacgcggt tgaaagcatc tttggagtga aagttgacaa 136741 agtcaacatc atgaactaca aaggcaaatc aaaacgtgtt ggacgctaca ctggtatgac 136801 tagccgtcgc agaaaagcga tcgtaaaact tactgcagac agcaaagaaa tcgaaatttt 136861 tgaagcttaa ttatctgtaa aaagaaggag ggaaattcaa aatggcgatt aaaaagtata 136921 aaccgacctc taatggacgt cgtggcatga caacttcaga ttttgctgaa atcacgactg 136981 acaagccgga aaaatccttg cttgctcccc ttcacaaaaa aggcggacgt aacaaccaag 137041 gtaaattgac tgtacgtcac caaggtggcg gacataaacg ccaataccgt gttatcgact 137101 tcaaacgcga taaagatggt atacctggac gcgttgctac agttgaatac gatccaaacc 137161 gttcagctaa catcgctcta atcaactatg cagacggaga aaaacgttac attcttgctc 137221 ctaaaggaat tcaagtaggt actgaaatca tgtcaggtcc tgaagctgac attaaagtag 137281 gtaatgcact tccacttatc aacatccctg ttggtacagt tgtgcataac attgaattaa 137341 aacctggtaa aggcggacag cttgtacgtt cagctggtac atctgctcag gttcttggta 137401 aagaaggtaa atacgttctt gtacgtctta actctggtga agttcgcatg atcctttctg 137461 cttgccgtgc ttctatcggt caagtaggta acgaacagca cgaacttatc aacattggta 137521 aagctggacg ttctcgctgg aaaggcatcc gtcctacagt tcgtggttct gtaatgaacc 137581 ctaacgatca cccacacggt ggtggtgaag gacgtgcgcc aatcggacgt aaatcaccaa 137641 tgtctccatg gggcaaacca actcttggat tcaagactcg taagaaaaag aacaaatccg 137701 ataaatttat cgtacgtcgt cgtaaaaata aataacgggg ttgtctacgg ttcttttcgg 137761 accgtagtgc aatcacgaag ggaggttcca aaatggctcg cagcttaaaa aaaggaccat 137821 ttgtcgatgg acacttgatg actaaaatcg agaaattaaa tgaaacagac aagaaacaag 137881 tcgtaaaaac ttggtctcgt cgttctacta ttttcccaca gtttattggt cacacaatcg 137941 cagtctatga cggacgtaaa cacgtgcctg tattcatctc tgaagatatg gtagggcaca 138001 agttgggtga attcgctcca actcgtacgt acaaaggtca tgctagtgat gacaaaaaaa 138061 caagacgcta agagaggagg cttttaaatg caagctaaag ctgttgcaag aacagtccgt 138121 attgctcctc gtaaagcacg tctagtaatg gacctgattc gaggcaagca agtaggtgag 138181 gcagtatcaa tcttgaacct tacaccaaga gctgcttctc caattatcga gaaagtatta 138241 aaatccgcta ttgcaaatgc tgagcataac tatgaaatgg acgctaacaa cctggttatt 138301 tctcaagcat tcgttgacga aggccctacg ttaaaaagat tccgcccacg tgctatggga 138361 cgtgcgagcc aaatcaacaa acgtacgagc cacattacaa tcgttgtatc agaaaagaag 138421 gagggataag tagtgggtca aaaggtaaat ccagtcggtc ttcgtatcgg agtcattcgt 138481 gattgggaat ctaagtggta cgctggtaaa gattacgctg acttcctgca cgaagattta 138541 aaaattcgtg aatacattag caaacgcctt tctgacgctt ctgtttctaa agtagaaatt 138601 gagcgtgcag caaaccgcgt taacattacg atccacacag ctaagcctgg tatggttatc 138661 ggtaaaggcg gttctgaagt cgaagcactt cgcaaagccc ttaacagcct tactggcaag 138721 cgtgtacaca ttaacattct tgaaatcaaa agagcagatc ttgatgcaca gctagttgct 138781 gacaacatcg ctcgtcaatt agaaaaccgt gtttctttcc gccgtgcgca gaaacaacaa 138841 atccaacgta ctatgcgtgc tggagcacaa ggtgtgaaaa caatggtttc tggtcgtctt 138901 ggcggtgcag atatcgctcg ttctgaatac tacagtgaag gaactgttcc attgcacaca 138961 ttacgtgcgg acattgacta tgcaacatct gaagctgata ctacttacgg taagcttggt 139021 gtaaaagtct ggatctatcg tggagaggtt cttcctacta agaagaaaaa tgaggaagga 139081 ggaaaataat atgttattac caaaacgcgt taaatatcgc agagagcatc gcggaaaaat 139141 gcgtggccgt gcgaaaggcg gtactgaagt acatttcgga gaattcggta tccaagctct 139201 agaagcttct tggattacta accgtcaaat cgaagctgca cgtattgcga tgactcgtta 139261 catgaaacgt ggcggtaaag tttggatcaa aattttccct tctaaacctt acactgctaa 139321 accacttgag gtacgtatgg gatccggtaa aggggctcca gaaggttggg tagctgttgt 139381 aaaaccgggc aaagttttat ttgaaatttc tggtgtgtct gaagaggttg ctcgtgaagc 139441 gcttcgcctt gcatctcaca aattgccaat taaaacgaag ttcgtaaaac gtgaagaaat 139501 tggtggtgaa tcaaatgaaa gctaatgaaa ttcgtgacct taccactgct gaaattgaac 139561 aaaaagtaaa gtctcttaaa gaagaacttt tcaatcttcg ctttcaatta gcgacaggac 139621 aacttgaaaa tactgctcgc attcgtgaag tgcgcaaagc tatcgcgcgc atgaaaactg 139681 tgattcgtga aagagaaatt gctgctaata aataatcact gaggggaggt cgtgagcatg 139741 agcgaacgta accaacgcaa agtttaccaa ggccgtgttg tttctgacaa aatggataaa 139801 accattactg ttgttgttga gacatacaaa aaacatacac tttacggtaa acgcgtaaaa 139861 tactcaaaaa aattcaaagc acatgatgaa aataatcaag ctaaaatcgg tgacatcgtt 139921 aagatcatgg aaactcgtcc attgtctgca actaagcgtt tccgtctagt tgaagttgtc 139981 gaagaagctg ttattatcta ataaagttcg gaattctttt tccgaaggga ggtaacaaat 140041 aatgattcaa caagagactc gtttaaaagt agctgacaac tctggcgcac gtgaagtact 140101 tactattaaa gttcttggtg gttctggacg taaaacagct aacattggtg atgtaattgt 140161 ttgcacggtt aaacaagcaa caccaggagg cgttgtcaaa aaaggtgaag tcgtaaaagc 140221 tgttatcgtt cgcactaaaa gcggagcgcg cagaagtgac ggttcataca tcagcttcga 140281 tgagaatgca tgtgttatca tccgtgacga caagagccca cgcggaactc gtatcttcgg 140341 accagttgct cgtgaattgc gtgaaaacaa ctttatgaaa attgtttctc tagctccaga 140401 agttatctaa ttgaaataaa tgccttactc aaggaggtgc gatcaggatg catgtaaaaa 140461 aaggcgataa agttatggtt atctctggta aagataaagg caaacaagga acaatccttg 140521 ctgctttccc taaaaaggac cgcgttttag ttgaaggtgt taacatggta aagaaacact 140581 ctaaaccaac tcaagctaac cctcaaggcg gtatttctaa tcaagaggcg ccaattcatg 140641 tatcaaacgt tatgccgctc gatcctaaaa caggtgaagt gactcgcgta ggatacaaag 140701 tggaagatgg caaaaaagtt cgtgtagcaa aaaaatctgg gcaagttcta gataaatagt 140761 attaaaagga agggaggtct atctcatgaa ccgccttaaa gaaaagtaca ataaagaaat 140821 tgcacctgct ttaatgacta agttcaacta tgattcagtc atgcaagtgc ctaaaatcga 140881 aaaaatcgta atcaacatgg gtgttggtga cgctgttcaa aacgccaaag caatcgacag 140941 tgctgttgag gaattaacgt ttatcgcagg tcaaaaacct gtcgttactc gtgcgaagaa 141001 atcaattgct ggattccgtc ttcgtgaggg aatgcctatc ggtgcgaaag taactcttcg 141061 cggagagcgc atgtatgatt tccttgataa acttatttct gtatctttac cgcgtgtacg 141121 tgacttccgc ggggtttcta aaaaatcttt cgacggtcgc ggtaactaca cacttggtat 141181 caaagaacag ttaatcttcc ctgaaattga ctacgataaa gtaacaaagg ttcgcggaat 141241 ggacatcgtt atcgtaacaa ctgctaatac tgacgaagaa gctcgtgagc tattaactca 141301 agtaggtatg ccgttccaga aataatcaat gaaagggagg cgaaatcgtg gctaaaaagt 141361 ctatgattgc gaaacaacaa cgtacaccaa agtttaaagt acaagagtac acacgctgtg 141421 aacgctgcgg acgtccgcat tcagtcattc gtaaatttaa actttgccgt atttgtttcc 141481 gtgagcttgc atataaagga caaattcctg gcgtgaaaaa agccagctgg taatccccaa 141541 gaaagggaag gaggtaatta tataatggtt atgacagatc caattgcaga tatgctaact 141601 cgtattcgca atgcaaacat ggtacgtcat gagaagcttg aaattcctgc ttctaaattg 141661 aaaagagaaa ttgctgaaat tttaaagcgt gaaggtttca ttcgtgacgt tgagttcgta 141721 gaagacagca aacaaggtat tatccgcgtt ttcttgaaat acggacaaaa caacgagcgc 141781 gttatcactg gtcttaaaag aatcagcaag cctggtttgc gtgtttatgc taaatctaat 141841 gaagtacccc gcgtacttaa cggtcttgga atcgcgatta tttctacatc acaaggtgtt 141901 ttaacggaca aagaagcccg tgcaaaacaa gctggtggag aagttctagc atacgtttgg 141961 taagaagttt aacatgaatg gaggtgtttg gtatgtctcg tgtaggtaag aagctacttg 142021 agattccttc tgatgttaca gtaacgttaa atgataacaa cactgtagct gtgaaaggac 142081 caaaaggaga attaactcgt acgtttcacc ctgatatgga gattaaagta gaggacaatg 142141 tgcttacagt cgctcgtcct tctgatcaaa aagagcaccg tgccctgcat ggtacgactc 142201 gcagtctgct tggcaacatg gttgaaggtg tatctaaagg atttgaaaga ggtttggaat 142261 tagtcggtgt cggttaccgt gcttctaaat ccggaaataa acttgtttta aacgttggat 142321 actctcatcc tgttgagatc gttcctgaag aaggcatcga aatcgaagtt ccttctcaaa 142381 caaaagtagt tgtaaaaggt acagacaaag aacgcgtagg agctattgct gctaacatcc 142441 gcgctgtacg ttctccagag ccttacaaag gtaaaggaat ccgctacgaa ggtgaagttg 142501 ttcgccgtaa agaaggtaaa tctgctaagt aagatcgctt aaagtgaaga aaggagtgac 142561 ctagatgatt acgaaaacta gcaaaaatgc tgctcgtctt aaaagacacg ctcgtgttcg 142621 cgctaaactt tccggtactg ctgaaagacc gcgcctgaac gttttccgtt ctaacaagca 142681 catttacgct caaatcatcg atgatgtaaa tggtgtaaca cttgctagtg catctactct 142741 cgataaagac ttgaacgttg aaagcactgg agatacttct gctgctacta aagttggaga 142801 attagttgca aaacgcgctg ctgaaaaagg catttctgac gtagtatttg accgtggcgg 142861 atacttatac catggacgtg taaaagcttt ggctgatgcc gctcgtgaag ctggacttaa 142921 attttaataa aagaaggagg gacacatgat tatgcgtcgt attgacccaa gcaaattaga 142981 gttagaagaa cgcttagtta cggttaaccg cgtagcgaaa gttgttaaag gtggtcgtcg 143041 tttccgcttc gcagctctag tcgttgtcgg tgacaaaaac ggacacgtag gattcggtac 143101 tggtaaagca caagaagtac cagaagcgat tcgcaaagct gttgaagatg cgaaaaagaa 143161 tttgattgaa gtaccaatgg ttggaactac aattccacac gaaatcatcg gacgtttcgg 143221 tgcaggtaac atcttgttaa aacctgcttc tgaaggtact ggagttatcg ctggaggccc 143281 tgtacgtgcg gtacttgagc tagctggtgt agctgatatc ctttctaagt ctttaggttc 143341 taacacaccg atcaacatga ttcgtgcaac acttcaaggt ttaagtgaac ttaaacgtgc 143401 tgaagacgtt gcgaagcttc gtggaaaatc tgtagaagaa ctgttaggat aaggagggaa 143461 cattaatggc taaattagaa attaccctca aacgaagtgt aatcggtcgc ccggaagacc 143521 aacgcgttac tgtaagaaca cttggtttaa agaaaacaaa ccaaactgtt gttcatgaag 143581 acaacgctgc gatccgtggt atgattaata aagtatctca tttagtttct gttaaagaac 143641 aataaaaata tttgatcgga taaggaggtg tcctaatgaa acttcatgaa ttaaaacctt 143701 cagaaggttc acgcaaaacg cgtaatcgcg taggtcgtgg tattggttct ggcaacggta 143761 aaacagctgg taaaggtcac aaaggtcaaa acgctcgttc tggcggcggt gtacgccctg 143821 gattcgaggg gggacaaatg cctttattcc aacgtcttcc taaacgtggt ttcactaaca 143881 tcaaccgcaa ggaatacgct gtagtcaacc tagacaaatt gaacggtttt gcagaaggaa 143941 cggaagtcac tcctgaactt cttctagaga ctggtgttat tagcaaactt aatgcaggag 144001 taaagattct tggcaacggt aaattagaga aaaaattaac tgtaaaagcc aataaattct 144061 ctgcttctgc gaaagaagct gttgaagctg ctggcggtac agctgaggtg atctaacttg 144121 tttaaaacaa tctccaactt tatgcgtgtg agtgatatca ggaataaaat catattcact 144181 ttactcatgc ttatcgtctt tcgcataggt gcgtttattc ctgtgcctta cgttaacgct 144241 gaagcgttac aggcacagtc tcaaatgggt gtttttgatc tccttaatac atttggcggc 144301 ggtgcgcttt accaattttc cattttcgca atgggaatta ctccttatat cacggcttcg 144361 atcatcattc agctgcttca gatggatgtg gtaccgaagt ttaccgagtg gtctaagcaa 144421 ggtgaagttg gccgccgtaa attagctcag ttcacaaggt actttacgat tgtgcttggt 144481 ttcatccaag cgttaggtat gtcatatgga ttcaacaatc tggcaaacgg tatgctgatc 144541 gaaaaatccg gtgtatcgac atatcttatc attgctttag tgctcactgg cggaactgcc 144601 tttttaatgt ggcttgggga acaaattact tctcatggag taggcaacgg aatatcgatc 144661 attatcttcg cggggattgt gtctagtatt ccaaaaacaa ttgggcaaat atatgagact 144721 caatttgtcg gcagcaacga tcagttgttt attcatattg tgaaagtcgc acttcttgtg 144781 attgcgattt tagcagttat tgttggagtt attttcattc agcaagccgt acggaaaatt 144841 gcgattcaat atgctaaagg cacaggtcgt tcacctgctg gcggaggtca gtctacacac 144901 cttccattga aagtgaatcc tgcaggggtt attccggtaa tctttgcggt tgcgtttttg 144961 ataacgccgc ggacgatcgc gtcattcttt ggaacaaacg atgtgacaaa gtggattcaa 145021 aacaactttg ataatacgca tccggtgggt atggcgatat atgttgcgtt gattattgcc 145081 tttacgtact tttatgcttt tgtacaggta aaccctgaac aaatggctga taaccttaaa 145141 aaacagggtg gctatatccc gggggttcgt ccagggaaaa tgactcaaga tagaattacg 145201 agcattttgt atcgacttac gtttgtgggt tctatattct tagccgtgat ttccattctt 145261 cctatctttt tcattcaatt cgctggattg cctcaaagtg cacaaattgg cggaacatct 145321 ttgttaattg ttgtcggggt agccttggag acaatgaaac aactagaaag ccagttggtg 145381 aaacgaaact accgtggatt tatgaaaaac tagaggaaat ggatttatcc attccctctt 145441 aataaagaga ggacggggga aatccgaatg aacttagtct taatggggct tcctggtgcc 145501 ggtaaaggca cacagggcga acgaattgtt gaggattatg ggattcctca tatctcaaca 145561 ggagatatgt tccgtgctgc tatgaaagaa gaaacaccac tcggactcga agcaaaatct 145621 tatattgata agggagagct cgtacctgac gaagtcacaa tcggaattgt aaaagagaga 145681 cttggcaaag atgattgtga aagaggtttt cttctggacg gatttccgcg aacagtcgct 145741 caagccgaag ctcttgaaga aattcttgag gaatacggca agccgattga ttatgtcatt 145801 aacattgaag tcgacaaaga tgttctgatg gaacgtctga ctggacgcag aatttgcagt 145861 gtttgcggca caacctatca tttagtcttt aatccgccga aaacgccggg tatttgtgat 145921 aaagacggag gcgaactcta tcaacgggca gatgataatg aggaaacagt ctctaaacgg 145981 cttgaggtaa acatgaagca aactcagcct ttactcgatt tctattcaga gaaaggttat 146041 cttgcaaacg tgaatggcca gcaggacatt caagacgttt atgcagatgt gaaggatctt 146101 cttggaggat taaaaaaatg attatctgta aaaccccacg tgaacttggt atcatgcggg 146161 aagcagggcg aatcgtggct ttaactcatg aagagttaaa aaagcacatt aaaccaggaa 146221 tctcgacaaa agaattggat caaattgccg aacgttttat taagaagcag ggtgcaatcc 146281 catcttttaa ggggtataat gggtttcgcg ggagcatttg cgtatcagtt aatgaagaac 146341 tcgttcacgg catacctggc agcagggtgc tgaaggacgg tgacatcatc agtattgata 146401 tcggtgctaa attaaatggt tatcatggtg actctgcatg gacatatccg gtaggaaaca 146461 tcagcgatga tgacaaaaaa cttctggaag tgacagagga gtctttatat aaaggcttgc 146521 aggaagcaaa accaggtgaa cgtttgtcga atatttccca cgcaatacaa acgtatgtcg 146581 aaaatgagca gttttcagtt gttagggagt atgtcggaca tggtgttggt caagacttgc 146641 atgaggaccc gcaaattcct cattacggtc cgcccaacaa aggaccacgg cttaaacctg 146701 gcatggttct cgctattgaa cctatggtga acgctggcag ccgctacgtg aaaacattgg 146761 ctgataactg gacggttgta acggtagatg ggaaaaagtg tgctcatttt gaacatacga 146821 ttgcgattac ggaaacgggt tttgatatac tgacgagagt ctagatgatg aaaataattc 146881 cgaagacaga tgtttttcaa gcttgatagg gcagaaagct tgggtgaaca ttggcaagac 146941 cgaattcatc ttgcttcttg tcgttggaat tttaaccatc atcaatgtac taacagcaga 147001 cggagaaaag cgtacatttc attctcctaa gaaaaagaat atcaatcatt taacccttta 147061 tgattgcgta tctccggaag ttcagaacag tataaacgaa acagggcgtg tgacaaactt 147121 cttttgaaat ttgtcagaaa gcaagttact gatttgaaga agggagaaca cttgaatggc 147181 gaaagacgat gtaattgaag tggaaggtac tatagtcgaa acactgccaa acgcgatgtt 147241 caaagttgaa cttgaaaatg gccacactgt tttggctcat gtatctggta aaatccgcat 147301 gcacttcatt cgcattttac ctggagacaa agttacggta gaattatctc catatgactt 147361 aactcgtggc aggattacgt accgttacaa ataaagcact ccggaaactg aaggaggttg 147421 gaaacacatg aaagtgagac catcagttaa accaatctgc gaaaaatgta aagttattcg 147481 cagaaaagga aaagtaatgg tgatctgtga aaatccaaag cataaacaaa aacaaggata 147541 atttataagg aggtgcccag agaatggctc gtattgctgg tgtagatatc ccacgtgaca 147601 aacgtgttgt tatttcttta acatacatct tcggaattgg ccgcacaacg gctcagcaag 147661 ttttaaaaga agctggagtt tcagaagata ctcgtgtgcg cgatcttact gaagaagaac 147721 ttggtaaaat ccgtgatatt attgacaaac tgaaagtaga aggtgacctt cgccgtgaag 147781 tttctcttaa tatcaaacgt ctgatcgaaa tcggaagcta ccgcggaatc cgtcatcgca 147841 gaggattacc tgttcgcgga caaaactcta aaaacaacgc gcgtactcgt aaaggtccgc 147901 gtcgtactgt agctaacaag aaaaaataag taagggaggt tcttaaacaa tggctgctgc 147961 tcgtaaatct aacacgcgta aacgtcgcgt gaaaaagaat attgagtctg gaattgctca 148021 tattcgttca actttcaata acacgatcgt tacgatcact gacactcatg gtaatgctat 148081 ttcttggtct agtgccggag ctttaggatt cagaggttct cgtaaatcta ctccttttgc 148141 tgcgcaaatg gctgcagaaa cagctgctaa aggttcaatc gaacatggtc ttaaaactct 148201 agaggttact gttaaaggac ctggttcagg ccgtgaagct gcaatccgtg cacttcaagc 148261 tgctggacta gaagtcactg ctatcagaga cgtaactcct gttcctcata acggatgccg 148321 tccaccaaaa cgtcgccgcg tgtaatttgt ttgtatagat tttgtgtccc tgtcaataat 148381 gggttatgat acagttattt atgaaacgaa tgcaccgact cgttgcctga gcacatacgg 148441 gactaaacaa tggggaattt cggatggaat ctcatatgat tctattcgag gtttcgacgt 148501 tttgaaggag ggttttaagt aatgatcgag attgaaaaac caaaaatcga aacggttgaa 148561 atcagcgacg atgccaaatt tggtaagttt gtcgtagagc cacttgagcg tggatatggt 148621 acaactctgg gtaactcctt acgtcgtatc ctcttatcct cactccctgg tgccgctgta 148681 acatcaatcc agatagatgg tgtactgcac gaattctcga caattgaagg cgttgtggaa 148741 gatgttacaa cgattatctt acacattaaa aagcttgcat tgaaaatcta ctctgatgaa 148801 gagaagacgc tagaaattga tgtacagggt gaaggaactg taacggcagc tgatattaca 148861 cacgatagtg atgtagagat cttaaatcct gatcttcata tcgcgactct tggtgagaat 148921 gcgagtttcc gagttcgcct tactgctcaa agaggacgtg ggtatacgcc tgctgacgca 148981 aacaagagag acgatcagcc aatcggcgtg attccgatcg attctatcta tacgccagtt 149041 tctcgtgtat cttatcaggt agagaacact cgtgtaggcc aagttgcaaa ctatgataaa 149101 cttacacttg atgtttggac tgatggaagc actggaccga aagaagcaat tgcgcttggt 149161 tcaaagattt taactgaaca ccttaatata ttcgttggtt taactgacga agctcaacat 149221 gctgaaatca tggttgaaaa agaagaagat caaaaagaga aagttcttga aatgacaatt 149281 gaagaattgg atctttctgt tcgttcttac aactgcttaa agcgtgcggg tattaacacg 149341 gttcaagagc ttgcgaacaa gacggaagaa gatatgatga aagttcgaaa tctaggacgc 149401 aaatcacttg aagaagtgaa agcgaaacta gaagaacttg gactcggact tcgcaaagac 149461 gattgactag tttcccttgt gaactaggat tttcgtgtgt ttattattca gaaacagcat 149521 tccaataaag gaggggacat cacatgtcat acagaaaact aggacgtacg agtgcacagc 149581 gtaaagctat gcttcgtgat cttacaactg atttgatcat caacgaaaga atcgaaacaa 149641 ctgaaacacg tgcgaaagaa cttcgctctg tagttgaaaa aatgatcacg cttggcaaac 149701 gcggtgatct tcacgctcgc cgtcaagctg ctgcatacat ccgcaacgag gttgcaaacg 149761 aagaaaataa tcaagatgca cttcaaaaat tattctctga cattgcaact cgttacgagg 149821 agcgccaagg tggatacaca cgtattatga agcttggtcc tcgccgtggt gacggagcac 149881 caatggcaat tatcgaattg gtttaatcac atatttttgt gtatctaaag aagggcggga 149941 cagtttctaa ctggatctat gccctttttt tagatactgc aacttttaat agagagaaaa 150001 gcagagcatt agctgagagg aggccggttt tccatgaatc aaaatcagtt gatatcggta 150061 gaggatatcg tatttcgata tcggaaggac gcagaaagac gagcactaga cggcgtctcc 150121 ctgcaggtgt atgagggtga atggcttgca atcgtaggtc ataacggttc agggaaatca 150181 acactggccc gggcattgaa tggtttaatt cttcctgaat caggcgacat tgaggttgcc 150241 gggattcaat tgacagagga atctgtttgg gaagtgcgta agaagatagg tatggtcttt 150301 caaaatccgg ataaccaatt tgtcggaacg actgttcgcg atgatgtggc ttttggttta 150361 gaaaacaatg gtgtaccgcg ggaagaaatg attgagagag tagactgggc agtaaaacag 150421 gtgaatatgc aagattttct cgatcaagag ccgcaccatc tctccggagg ccaaaagcag 150481 agagttgcga ttgcgggggt tattgccgca cgtcctgata ttattatctt agatgaagca 150541 acatccatgc ttgatccgat cgggcgagaa gaagtgcttg aaacggtaag acatttaaaa 150601 gagcagggca tggcgactgt catatccatt acacatgacc tgaatgaggc agcaaaagca 150661 gacaggatca ttgtcatgaa tggcggtaaa aaatatgctg aagggccgcc tgaagagatt 150721 tttaaattga ataaagaact tgttcgaatt gggcttgatt tacccttctc attccagctt 150781 agccagcttt taagagaaaa tggactggct ttggaagaaa accatttgac tcaggaaggg 150841 ctggtgaaag agctgtggac attacaatca aagatgtaga gcatcgctat cagatgaaga 150901 ccccgtttga gcgcctagca ctgtatgata tcaatgcatc gattaaagaa ggaagctacg 150961 tagccgttat cgggcataca ggctctggca agtccactct tctacagcac ctaaatggtc 151021 tcctgaagcc gacgaaggga cagatatcac taggcagcac tgtcattcag gcagggaaaa 151081 agaataaaga tctgaaaaaa cttcgtaaaa aagtcggaat cgttttccaa tttcctgagc 151141 atcaattatt cgaagaaaca gttcttaaag atatttcatt cggaccgatg aactttggtg 151201 ttaaaaaaga agatgctgaa caaaaagcga gagagatgct gcagcttgta ggtttatcag 151261 aagagctttt ggacaggtca ccctttgaat taagcggggg acaaatgcgc agagttgcaa 151321 ttgccggcgt acttgcaatg gaccctgaag tgcttgttct ggatgaaccg actgcaggat 151381 tggacccaag agggcgaaaa gagattatgg acatgtttta tgagcttcat caacgtggga 151441 acttgacgac gatccttgtg acacacagca tggaggatgc agctgcatac gctgatgaaa 151501 tgattgttat gcataaagga acgatacaag catcaggcag tccgcgtgat ctgtttttaa 151561 agggtgaaga gatggccggc tgggggctgg atcttcctga aacaataaaa ttccaaagac 151621 accttgaagc tgcactgggt gtgagattta atgagcctat gctcacaatc gaagatgccg 151681 ctgccgaaat ccgtgctctt tttcagggag agaagacttt atgatggaca gcatgattat 151741 cggcaagtat gtaccgggga cttcacttgt gcaccggctt gaccccagaa caaaactgat 151801 cacgatcttt ttatttgtct gcattgtatt cttagccaat aatgttcaga catatgcgtt 151861 gcttggttta tttacaattg gcgtcgtttc tttaacaaga gttcctttct cttttttaat 151921 gaaagggctg aagccaatca tctggattgt cctttttacg ttccttcttc acattcttat 151981 gacacatgaa ggaccgatta tctttcaaat aggttttttc aaagtctatg agggcggtct 152041 ggttcagggg atattcattt ctcttagatt cgtctatttg attttaatca caaccttatt 152101 aacgcttacg actacaccga ttgagattac cgatggaatg gagcagctgc tgaacccatt 152161 gaaaaaatta aagcttcctg ttcatgagct ggctcttatg atgtcaattt ctttacggtt 152221 tattccgaca ctgatggagg agacagataa gatcatgaag gctcagatgg cgcgaggcgt 152281 tgattttaca agcgggcctg tcaaagaaag agtgaaggct attgtcccgc ttcttgtccc 152341 gctcttcgtc agcgcattta aacgcgccga agagcttgcg gtggcaatgg aagcaagagg 152401 ctatcaaggc ggagaaggac gtacgaaata tagaaagctt gtatggacag gaaaagacac 152461 ttctgtcatt gtcagcttaa ttgtattagc tgctttgtta tttttcttaa gggcttagag 152521 gtgctgtatg agactgaaat gcacgatttc ttatgacgga catttgttta acggttatca 152581 ggttcagccg ggcaaaagaa cggttcagga tgaactggag aaggctttgg ctgtcctgca 152641 taagtcaaaa gacagaattc cggtcgtttc gtctggaaga acagacagcg gggttcacgc 152701 agccggacag gtgattcatt ttgacactcc gctgtctatc ccggctgaga gatggccata 152761 tgccttaaat gcactgcttc cggacgatat cgcagtcaaa caggcagaaa ttgcggatga 152821 tgggttccat gcacgattta gcgcagtcaa aaaagaatat cgctactttg tatacacgga 152881 gaaacacccg gacgtattta aacggcatta cgcttaccat ttttcatatc gccttaatgt 152941 gcaggacatg agagaagcgg caaagcatct tatagggaca catgatttta cgagcttttg 153001 cgcggctaaa acagaagtgc aggacaaggt aagaacgata tacgaacttg attggactga 153061 gacggctgac ggcctgcaaa tgcggatcac aggcagcggt ttcttatata atatggtcag 153121 aattattgcg ggtactttgc ttgatgcagg tattggaaaa atttctcccg atgaggtgaa 153181 atccatgctg gaagcgaagg atcgcgaagc ggcagggcgc acagcgccgg ggcacgggct 153241 atatttatgg aacgtttact atgacaacta aaccaggtgt ataatatttt cttgacagag 153301 tctgcataaa gttataagat atcatatggt atgtatttca accccacgat aagccccgga 153361 acttattgtg ttgtgaaata gaacgtaatc gaagtttatt gaaaatgaca gatcatttag 153421 gagggaaatt caatgcgtac aacacctatg gctaacgcaa gtactattga acgcaagtgg 153481 ttagttgttg atgctgctgg caagacttta ggtcgtcttt cttcagaagt tgcagctatc 153541 cttcgcggaa aacacaaacc aacttacaca ccacacgttg atactggaga tcatgtgatc 153601 atcatcaacg ctgaaaaaat cgagttaact ggtaaaaagt taactgacaa aatctactac 153661 cgtcacactc aacatccagg cggattaaaa tcaagaactg ctcttgaaat gcgtacaaac 153721 taccctgaga aaatgcttga gcttgctatc aaaggcatgc ttccaaaagg ttctctaggt 153781 cgtcaaatgt tcaaaaaatt gaacgtatac cgtggttctg agcatccaca cgaagcacaa 153841 aaacctgaag tttacgaact tcgcggttaa ttaaaaagga ggttaccaat ttggcacagg 153901 ttcaatatta cggtactggc cgtcgtaaaa gctctgtagc gcgtgtgcgt ttagttccag 153961 gagaaggccg tatcgtcgtt aataatcgtg aaatcagcga acatatccca tctgcagctt 154021 taatcgaaga tatcaaacaa ccattaactt tgactgaaac agctggcact tatgatgttt 154081 tagtaaacgt acatggaggc ggcctatctg gtcaagctgg agcaatccgt cacggtatcg 154141 ctcgtgcttt gcttgaagca gatccagaat accgtacaac tcttaaacgt gcaggtcttc 154201 tgactcgtga cgctcgtatg aaagaacgta aaaaatacgg tcttaaaggc gctcgtcgtg 154261 cacctcagtt ctcaaaacgt taattttacg ttttcaaaaa gctctcgacc ttgggttggg 154321 agcttttttc tttcaataaa acgtggcagt cccgcataaa aataacaact gaatggacgc 154381 ttgacggggt taagcaaatt gtttgtttat aaacggtctc tttgtaataa tcatggtaga 154441 tttcattctt attcaattgg aagttcggtc aatgtttatt atcgttatgt gatcagccca 154501 gctccatcta accactgtat ctcatccgtt aaagttcact gctgattctt aacccggaga 154561 aacaatagct ctcattgcta atggctttat gtaacgaagt aaaagtaaat ctgatgatat 154621 aaatcacata tctcctttgt gatttttttg cgtttttatg aacttttttc taaatatgca 154681 aagggaaagc gatatcaatc tagaaatatt tgttatactc tatacattaa agtaaggaga 154741 agattcatga atgcgttagt agctcataat agcaaagcct gggataaaaa agtagaaaca 154801 ggcaatgaat ggactgttgc tgttgaacag caggttatcg aacaagcaaa aaaaggcaat 154861 tgggatataa gggtaacacc aatgaaagat gtaccgaagg attggtttcc gcctatcaaa 154921 ggtctgaaag tactctgttt agcatcaggc ggcggccagc agggtccagt tttggcagcc 154981 gcaggcgcgg atgtcactgt attagataac tcagaaaaac agctgaatca ggatagaatg 155041 attgctgagc gagatggtct gacgatacac actgtcaaag gaagcatgga cgatttaagt 155101 gtatttaatg atgaatcatt tgatgtcatt gtacatcctg ttgccaatgt ttttgttgag 155161 aatgtcctcc cggtatggaa ggaagcgtac cgtgtgttga aaaggaacgg cattctaatc 155221 tcgggttttg tcaatcctgt tgtatttctg tttgatacag aattagaaca gcaaggtgtt 155281 ttaaaagtaa aacactctat tccatacgct gacccagaag atcttccgaa acataaagtg 155341 aaaaaactga tcgaaaataa tgaggctctg gaattcggcc attccttaga agaccaaatc 155401 aaaggccaaa ttgatgccgg ttttatcgtt actggttttt atgaagataa aggcggtttt 155461 gtattagacc aatatatcca tacatattct gcaacaagaa gcgtgaaagt atgaaaagca 155521 gcgacctgtt agaggggctg cttttttcat aaccaattac agaacatttg ttcctcaccc 155581 tgcagaaagc tgatttttta tcaatgttac accttcattt gggcgaattt ccaaccgaat 155641 tcgggcattg tttcatcatc caaacctcaa aataatcggt aaaaggagag tgaatttata 155701 tggcagaagt actgtctttt atggatgtga aacgccaaaa ggattttgaa ttagaaaaga 155761 acttgctcaa agaactctct ctgagacaaa ttatccagtc tgttaaggat tgtttggaac 155821 cattatttcc atttttacat gatgaacgag atattattac cgaaggctgt attgattttg 155881 cgattgaagc ttatttgtta ggcgggcgtt ttgggatatt cggctattac ggagaatcaa 155941 tgcagagtat cagtgcccgc tctgcaagag aagaagaaga gctgcgtatg gagttttttg 156001 attatctcta taattggata cacgagcaat acgcaacatt tgataaaaac actgtttatg 156061 aagcggcacg caagttcatt aaagattggt ggacagcagg gtttgttcaa agagaaaaac 156121 agtgtaagct tcgcatgcgg taatcatatt tcccgaccct gtcccatagt tatgtaataa 156181 cggacaagcg ggaggggaag ggatgaggaa aaagcttaaa tggctcagtt ttttgctagg 156241 cttcatcata ttactatttc tgttcaagta tcagttcagc aataacgact cttggaagcc 156301 gtggagcctg cccttgagcg gtaaaatcat ttatctagat ccaggtcatg gcgggcctga 156361 cggcggagca gtcggcggaa agctgttaga gaaggatgtt accctggaag tggcctttag 156421 agtcagggat tatcttcaag aacaaggagc gcttgttatc atgaccagag aaagtgatac 156481 tgatctcgct ccagaaggaa caaaaggcta tagccgacga aaagctgagg atctaagaca 156541 acgagtcaaa ttaataaacc attcagaggc ggagctctat atcagcattc atcttaatgc 156601 gattccgtca caaaaatgga gcggagccca aagcttttat tacgggaaat atgcggaaaa 156661 tgagaaagtc gcaaaataca ttcaggatga gctgagaaga aatctggaaa acacaacccg 156721 gaaagcaaag cggattcatg gtatctactt aatgcaaaac gtcaccaaac cgggggcgct 156781 tatagaagtc ggatttttat ccaatccaag tgaagcaacg ttgctcggta aaccgaaata 156841 tcaagacaag gtggcatctt ccatatataa aggcattttg cgatatttca cagaaaaagg 156901 agaccctccg gagtaatgga gggttttctt gtggttctaa gcataagaca cccgccattt 156961 atgtatgata taataataat tgtaaacgaa tacacaaaag ggtgaggttc gatgataaga 157021 gaagatgaag taagaaaact agtcggagaa atgcgcgaac cttttcttca aagacctctg 157081 ggagaattgg atgccgttaa ggaaattaaa ataaagcctg aaaaacggca tatcagtgta 157141 aaagtcgctc ttgcaaaaac aggaactgca gaacaaatgc agattcagca agagatcgta 157201 aacgtattaa aaggggcagg agctgagaca gtcggccttc gatttgaaga gctgcctgaa 157261 gaaacggttg ctaaattccg ggcgccgtca gctgagaaaa aaacattatt aaatatggat 157321 aacccgccag tctttcttgc tgtagcaagt ggaaaaggcg gcgtaggcaa gtcaactgtg 157381 tcagtaaacc tagctatttc tctggctcgt ctagggaaaa aggttggttt aattgatgcg 157441 gatatttatg ggttcagtgt gccggacatg atgggtatca ctgtgcgtcc aacaattgaa 157501 ggagagaaac ttcttcctgt tgaacgcttt ggagtaaagg tcatgtcaat gggctttttc 157561 gtagaagaaa atgccccggt cgtatggaga gggccgatgc tcggcaaaat gctgaataat 157621 tttttccatg aagtagagtg gggagaagta gactatatcg ttcttgatct tccgcctggt 157681 acaggggacg ttgctctcga tgtacataca atgcttccga gctgcaaaga aattatcgta 157741 tctacgccac atccgacagc tgcttttgtc gcggccagag cgggctctat ggcgattaaa 157801 accgatcatg aggtcgtggg tgtcatagag aacatggctt attatgaaag tgcaaagaca 157861 ggggaaagag aatatgtgtt tggaaaaggc ggaggagata aactggctga ggaactaaac 157921 gtgcctttgc tcggcagaat cccattgaaa cagcccgatt gggataagga ccaatttgct 157981 ccgtctgttt atgacgaaaa tcatccaatc ggagaaatat atcaggacat cgcaaaaaaa 158041 atagatgcaa aaatgtcagt gcaggtataa aaggtgaacc gggattccag atcccggctt 158101 tccctttatt cactttcttt tgctgtgtct tttgctgctt ttttcagctc atcttcgaac 158161 tgctttttgt aaagcggact agaaagtgtt tcgttaataa cctcttctaa ataactgcgg 158221 aattcttggc tttttgccag ctggctgtac tttttatcca tgccgggatc ctgcataacg 158281 ctcatcagca tcttctggta atctggatcc ttcatcagct ttttaatcac tttttcatgc 158341 tctgtctgaa gagttttggc aaagccctca gcaaaatcag tgtcttcaaa gatgtttttc 158401 caaaattctt cacctttttt agatgtgagt gttttttcta ttgttccttt aattgcatct 158461 tggtcaatca ccagcgcttc attcatggca tcatcattta ataattcctt aatagctttc 158521 tttccatcat cagtttttaa tatatcaaca accatttttt tggtctgatc atagtccata 158581 tccgctgctt ggtcttttgg agcgcaagct gttacagata ataacaaaaa acagctcatc 158641 aatagcgttt tggcttttga catgcttaag ctcctttcac atacttgtct tacctttaat 158701 atgattcatc tgtttggaat tatacataac aaaatatcgc tgttcgcgat ttttgagggg 158761 atgaataaag aaatgaaaag ccgtggttta gttcgttttt tcttttctat tttagctgtc 158821 ggggcgctta tcacgagtat tgtgggtttt gctttaaagt ggggagaata tagagggctg 158881 tttctaacat ttgaagcggg acagattttc tctgttttat tttggtttat cggtgtaggc 158941 atgattttca gtgtgatcag ccaaatgggt tttttcgtgt ttttaacagt tcatcggttt 159001 gcgcttgaga tattaaggtc ctcctctttg tggaatttgc tgcagttgtt tttcatcctg 159061 tttgttgctt ttgatttaat gtacgtgcgt tttttatttt ttggagagag cggagaatcg 159121 ctggctggct atgcgtggtt accggtgttt ttattgatct ttggagtgat tacagcttat 159181 ataaagcaaa agcagtcctc taagaaaaca tttgtgtcat cgttattttt gatggttgtg 159241 attaccgcat tagaatggtt ccctgcatta agagtaaatg atgaggactg gctttattta 159301 atgctttttc cgttaatggc atgtaatgcc ttccaattgc tgatgctgcc gaagtttgca 159361 gcaaagtaat tactttacct ctgcggattt ggcatcagaa tttgcgatga gatcacccac 159421 ggttacattt tttaatcctt tttctttcag ctgatggatg atatcaggca atgcttcttc 159481 tgtttgtttt gcagaatcgg aggcatgtaa aagaataatg tctccaccgg aaacttgctt 159541 ggtcacattg tcgatgattt tttcaactcc gggatttgtc cagtcttgag agttcacact 159601 gtaatgaacg actgtataat tgtattgctt tgcgaccttt agaacattct tattgaattg 159661 gccggtaggg ggtcttaata gctgtatgtc tttgacccct aacttttcaa aggctgtttg 159721 cgcacggttc atgtcctttt ttatttcgct gctctctaaa ttggcatagt ttttataagc 159781 gtagcccatg ctcccgattt gatggccgtc ctttacgata cgggccactg tgtcgggatg 159841 gcgttctgcc caagaagcgg acaggaaaaa cgttgcgttt ttaatcccgt ttgctttcag 159901 agtattaagt atcggttctg ctctctcatc accccagctg atatcgaaag taagtgaaat 159961 atctttagag tctgtttctc ctttataaat ggctttaggt ccggtgtcag ttgaaaacac 160021 gggaagcggg acagctcttt ggatataaaa aaagctggca gctgcaaatg cggcgataag 160081 tataataatt aattgtttta cccgtttaat gtgccacaca tagaagtgat tcactgatga 160141 tgcctcctta tcttgtccat cattcttgtt ttacatctta tgagcatgga caattgaata 160201 taaccgataa aatgtctctt cacatacagc ctaaattggg tgttgacctt ttgataatat 160261 ccgtgatata ttattattcg tcgctgataa acagctgaca tcaactaaaa gcttcattaa 160321 atactttgaa aaaagttgtt gacttaaaag aagctaaatg ttatagtaat aaagctgctt 160381 cgttaagcgg cagtaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca 160441 tttttataaa tcgcacagcg atgtgcgtag tcagtcaaac tactttatcg gagagtttga 160501 tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cggacagatg 160561 ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt 160621 aagactggga taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg 160681 ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta 160741 gttggtgagg taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg 160801 ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc 160861 gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta 160921 aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc 160981 taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc 161041 gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa 161101 gcccccggct caaccgggga gggtcattgg aaactgggga acttgagtgc agaagaggag 161161 agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa 161221 ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt 161281 agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc 161341 cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa 161401 actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca 161461 acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc 161521 ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 161581 gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc 161641 taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc 161701 cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga 161761 ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg 161821 tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc 161881 ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc 161941 ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag 162001 ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga 162061 ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc 162121 gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaagtaa tacaagatat 162181 cacatagtga ttctttttaa cggttaagtt agaaagggcg cacggtggat gccttggcac 162241 taggagccga tgaaggacgg gacgaacacc gatatgcttc ggggagctgt aagcaagctt 162301 tgatccggag atttccgaat ggggaaaccc accactcgta atggagtggt atccatatct 162361 gaattcatag gatatgagaa ggcagacccg gggaactgaa acatctaagt acccggagga 162421 agagaaagca aatgcgattc cctgagtagc ggcgagcgaa acgggattag cccaaaccaa 162481 gaggcttgcc tcttggggtt gtaggacact ctgtacggag ttacaaagga acgaggtaga 162541 tgaagaggtc tggaaaggcc cgccatagga ggtaacagcc ctgtagtcaa aacttcgttc 162601 tctcctgagt ggatcctgag tacggcggaa cacgtgaaat tccgtcggaa tccgggagga 162661 ccatctccca aggctaaata ctccctagtg accgatagtg aaccagtacc gtgagggaaa 162721 ggtgaaaagc accccggaag gggagtgaaa gagatcctga aaccgtgtgc ctacaagtag 162781 tcagagcccg ttaacgggtg atggcgtgcc ttttgtagaa tgaaccggcg agttacgatc 162841 tcgtgcaagg ttaagcagaa gatgcggagc cgcagcgaaa gcgagtctga atagggcgca 162901 tgagtacgtg gtcgtagacc cgaaaccagg tgatctaccc atgtccaggg tgaagttcag 162961 gtaacactga atggaggccc gaacccacgc acgttgaaaa gtgcggggat gaggtgtggg 163021 taggggtgaa atgccaatcg aacctggaga tagctggttc tctccgaaat agctttaggg 163081 ctagcctcaa ggtaagagtc ttggaggtag agcactgatt ggactagggg cccctaccgg 163141 gttaccgaat tcagtcaaac tccgaatgcc aatgacttat ccttgggagt cagactgcga 163201 gtgataagat ccgtagtcga aagggaaaca gcccagaccg ccagctaagg tcccaaagta 163261 tacgttaagt ggaaaaggat gtggagttgc ttagacaacc aggatgttgg cttagaagca 163321 gccaccattt aaagagtgcg taatagctca ctggtcgagt gactctgcgc cgaaaatgta 163381 ccggggctaa acgtatcacc gaagctgcgg actgttcttc gaacagtggt aggagagcgt 163441 tctaagggct gtgaagccag accggaagga ctggtggagc gcttagaagt gagaatgccg 163501 gtatgagtag cgaaagaggg gtgagaatcc cctccaccga atgcctaagg tttcctgagg 163561 aaggctcgtc cgctcagggt tagtcgggac ctaagccgag gccgaaaggc gtaggcgatg 163621 gacaacaggt tgatattcct gtaccacctc ctcaccattt gagcaatggg gggacgcagg 163681 aggatagggt aagcgcggta ttggatatcc gcgtccaagc agttaggctg ggaaataggc 163741 aaatccgttt cccataaggc tgagctgtga tggcgagcga aatatagtag cgaagttcct 163801 gattccacac tgccaagaaa agcctctagc gaggtgagag gtgcccgtac cgcaaaccga 163861 cacaggtagg cgaggagaga atcctaaggt gatcgagaga actctcgtta aggaactcgg 163921 caaaatgacc ccgtaacttc gggagaaggg gtgctctgtt agggtgcaag cccgagagag 163981 ccgcagtgaa taggcccagg cgactgttta gcaaaaacac aggtctctgc gaagccgtaa 164041 ggcgaagtat aggggctgac gcctgcccgg tgctggaagg ttaagaggag cgcttagcgt 164101 aagcgaaggt gcgaattgaa gccccagtaa acggcggccg taactataac ggtcctaagg 164161 tagcgaaatt ccttgtcggg taagttccga cccgcacgaa aggcgcaacg atctgggcac 164221 tgtctcaacg agagactcgg tgaaattata gtacctgtga agatgcaggt tacccgcgac 164281 aggacggaaa gaccccgtgg agctttactg cagcctgata ttgaatgttg gtacagcttg 164341 tacaggatag gtaggagcct tggaaaccgg agcgccagct tcggtggagg catcggtggg 164401 atactaccct ggctgtattg accttctaac ccgccgccct tatcgggcgg ggagacagtg 164461 tcaggtgggc agtttgactg gggcggtcgc ctcctaaaag gtaacggagg cgcccaaagg 164521 ttccctcaga atggttggaa atcattcgca gagtgtaaag gcacaaggga gcttgactgc 164581 gagacctaca agtcgagcag ggacgaaagt cgggcttagt gatccggtgg ttccgcatgg 164641 aagggccatc gctcaacgga taaaagctac cccggggata acaggcttat ctcccccaag 164701 agtccacatc gacggggagg tttggcacct cgatgtcggc tcatcgcatc ctggggctgt 164761 agtcggtccc aagggttggg ctgttcgccc attaaagcgg tacgcgagct gggttcagaa 164821 cgtcgtgaga cagttcggtc cctatccgtc gcgggcgcag gaaatttgag aggagctgtc 164881 cttagtacga gaggaccggg atggacgcac cgctggtgta ccagttgttc tgccaagggc 164941 atcgctgggt agctatgtgc ggacgggata agtgctgaaa gcatctaagc atgaagcccc 165001 cctcaagatg agatttccca ttccgcaagg aagtaagatc cctgaaagat gatcaggttg 165061 ataggtctga ggtggaagtg tggcgacaca tggagctgac agatactaat cgatcgagga 165121 cttaaccata tttttgaatg atgtcacatc tgttatctag ttttgagaga acactctcaa 165181 tttgtttggt ggcgatagcg aagaggtcac acccgttccc ataccgaaca cggaagttaa 165241 gctcttcagc gccgatggta gtcgggggtt tccccctgtg agagtaggac gccgccaagc 165301 agatttatta attctaccat gtttgtttat gaagctttat attattccgc agtagctcag 165361 tggtagagct atcggctgtt aaccgatcgg tcgtaggttc gaatcctacc tgcggagcca 165421 ttgcttccat agctcagcag gtagagcact tccatggtaa ggaagaggtc agcggttcga 165481 gcccgcttgg aagcttaaat gtattattac caaggtttct cataaggaga aagctttttt 165541 tattgcgata tgcggaagta gttcagtggt agaacaccac cttgccaagg tgggggtcgc 165601 gggttcgaat cccgtcttcc gctccattta tcctaacggg atattgtaaa ttgaattgcg 165661 cccgtagctc aattggatag agcgtttgac tacggatcaa aaggttaggg gttcgactcc 165721 tctcgggcgc gccatatctt ttaatagaat agataggaaa tcgggaagta gctcagcttg 165781 gtagagcaca tggtttggga ccatggggtc gcaggttcga atcctgtctt cccgaccatt 165841 ttttatgggg ccttagctca gctgggagag cgcctgcttt gcacgcagga ggtcagcggt 165901 tcgatcccgc taggctccac caaaagtttt taaaaaagtt attgactttg aagaagtgac 165961 attgtatact aataaagttg ctttaacaaa gcggacaaac aaaatgatct ttgaaaacta 166021 aacaagacaa aacgtacctg ttaattcagt ttttaaaaat cgcacagcga tgtgcgtagt 166081 cagtcaaact actttatcgg agagtttgat cctggctcag gacgaacgct ggcggcgtgc 166141 ctaatacatg caagtcgagc ggacagatgg gagcttgctc cctgatgtta gcggcggacg 166201 ggtgagtaac acgtgggtaa cctgcctgta agactgggat aactccggga aaccggggct 166261 aataccggat ggttgtttga accgcatggt tcaaacataa aaggtggctt cggctaccac 166321 ttacagatgg acccgcggcg cattagctag ttggtgaggt aacggctcac caaggcaacg 166381 atgcgtagcc gacctgagag ggtgatcggc cacactggga ctgagacacg gcccagactc 166441 ctacgggagg cagcagtagg gaatcttccg caatggacga aagtctgacg gagcaacgcc 166501 gcgtgagtga tgaaggtttt cggatcgtaa agctctgttg ttagggaaga acaagtaccg 166561 ttcgaatagg gcggtacctt gacggtacct aaccagaaag ccacggctaa ctacgtgcca 166621 gcagccgcgg taatacgtag gtggcaagcg ttgtccggaa ttattgggcg taaagggctc 166681 gcaggcggtt tcttaagtct gatgtgaaag cccccggctc aaccggggag ggtcattgga 166741 aactggggaa cttgagtgca gaagaggaga gtggaattcc acgtgtagcg gtgaaatgcg 166801 tagagatgtg gaggaacacc agtggcgaag gcgactctct ggtctgtaac tgacgctgag 166861 gagcgaaagc gtggggagcg aacaggatta gataccctgg tagtccacgc cgtaaacgat 166921 gagtgctaag tgttaggggg tttccgcccc ttagtgctgc agctaacgca ttaagcactc 166981 cgcctgggga gtacggtcgc aagactgaaa ctcaaaggaa ttgacggggg cccgcacaag 167041 cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac cttaccaggt cttgacatcc 167101 tctgacaatc ctagagatag gacgtcccct tcgggggcag agtgacaggt ggtgcatggt 167161 tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc aacccttgat 167221 cttagttgcc agcattcagt tgggcactct aaggtgactg ccggtgacaa accggaggaa 167281 ggtggggatg acgtcaaatc atcatgcccc ttatgacctg ggctacacac gtgctacaat 167341 ggacagaaca aagggcagcg aaaccgcgag gttaagccaa tcccacaaat ctgttctcag 167401 ttcggatcgc agtctgcaac tcgactgcgt gaagctggaa tcgctagtaa tcgcggatca 167461 gcatgccgcg gtgaatacgt tcccgggcct tgtacacacc gcccgtcaca ccacgagagt 167521 ttgtaacacc cgaagtcggt gaggtaacct tttaggagcc agccgccgaa ggtgggacag 167581 atgattgggg tgaagtcgta acaaggtagc cgtatcggaa ggtgcggctg gatcacctcc 167641 tttctaagga tattatacgg aatataagac cttgggtctt ataaacagaa cgttccctgt 167701 cttgtttagt tttgaaggat cattccttcg aaacgtgttc tttgaaaact agataacagt 167761 agacatcaca ttcaagtaat acaagatatc acatagtgat tctttttaac ggttaagtta 167821 gaaagggcgc acggtggatg ccttggcact aggagccgat gaaggacggg acgaacaccg 167881 atatgcttcg gggagctgta agcaagcttt gatccggaga tttccgaatg gggaaaccca 167941 ccactcgtaa tggagtggta tccatatctg aattcatagg atatgagaag gcagacccgg 168001 ggaactgaaa catctaagta cccggaggaa gagaaagcaa atgcgattcc ctgagtagcg 168061 gcgagcgaaa cgggattagc ccaaaccaag aggcttgcct cttggggttg taggacactc 168121 tgtacggagt tacaaaggaa cgaggtagat gaagaggtct ggaaaggccc gccataggag 168181 gtaacagccc tgtagtcaaa acttcgttct ctcctgagtg gatcctgagt acggcggaac 168241 acgtgaaatt ccgtcggaat ccgggaggac catctcccaa ggctaaatac tccctagtga 168301 ccgatagtga accagtaccg tgagggaaag gtgaaaagca ccccggaagg ggagtgaaag 168361 agatcctgaa accgtgtgcc tacaagtagt cagagcccgt taacgggtga tggcgtgcct 168421 tttgtagaat gaaccggcga gttacgatct cgtgcaaggt taagcagaag atgcggagcc 168481 gcagcgaaag cgagtctgaa tagggcgcat gagtacgtgg tcgtagaccc gaaaccaggt 168541 gatctaccca tgtccagggt gaagttcagg taacactgaa tggaggcccg aacccacgca 168601 cgttgaaaag tgcggggatg aggtgtgggt aggggtgaaa tgccaatcga acctggagat 168661 agctggttct ctccgaaata gctttagggc tagcctcaag gtaagagtct tggaggtaga 168721 gcactgattg gactaggggc ccctaccggg ttaccgaatt cagtcaaact ccgaatgcca 168781 atgacttatc cttgggagtc agactgcgag tgataagatc cgtagtcgaa agggaaacag 168841 cccagaccgc cagctaaggt cccaaagtat acgttaagtg gaaaaggatg tggagttgct 168901 tagacaacca ggatgttggc ttagaagcag ccaccattta aagagtgcgt aatagctcac 168961 tggtcgagtg actctgcgcc gaaaatgtac cggggctaaa cgtatcaccg aagctgcgga 169021 ctgttcttcg aacagtggta ggagagcgtt ctaagggctg tgaagccaga ccggaaggac 169081 tggtggagcg cttagaagtg agaatgccgg tatgagtagc gaaagagggg tgagaatccc 169141 ctccaccgaa tgcctaaggt ttcctgagga aggctcgtcc gctcagggtt agtcgggacc 169201 taagccgagg ccgaaaggcg taggcgatgg acaacaggtt gatattcctg taccacctcc 169261 tcaccatttg agcaatgggg ggacgcagga ggatagggta agcgcggtat tggatatccg 169321 cgtccaagca gttaggctgg gaaataggca aatccgtttc ccataaggct gagctgtgat 169381 ggcgagcgaa atatagtagc gaagttcctg attccacact gccaagaaaa gcctctagcg 169441 aggtgagagg tgcccgtacc gcaaaccgac acaggtaggc gaggagagaa tcctaaggtg 169501 atcgagagaa ctctcgttaa ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg 169561 tgctctgtta gggtgcaagc ccgagagagc cgcagtgaat aggcccaggc gactgtttag 169621 caaaaacaca ggtctctgcg aagccgtaag gcgaagtata ggggctgacg cctgcccggt 169681 gctggaaggt taagaggagc gcttagcgta agcgaaggtg cgaattgaag ccccagtaaa 169741 cggcggccgt aactataacg gtcctaaggt agcgaaattc cttgtcgggt aagttccgac 169801 ccgcacgaaa ggcgcaacga tctgggcact gtctcaacga gagactcggt gaaattatag 169861 tacctgtgaa gatgcaggtt acccgcgaca ggacggaaag accccgtgga gctttactgc 169921 agcctgatat tgaatgttgg tacagcttgt acaggatagg taggagcctt ggaaaccgga 169981 gcgccagctt cggtggaggc atcggtggga tactaccctg gctgtattga ccttctaacc 170041 cgccgccctt atcgggcggg gagacagtgt caggtgggca gtttgactgg ggcggtcgcc 170101 tcctaaaagg taacggaggc gcccaaaggt tccctcagaa tggttggaaa tcattcgcag 170161 agtgtaaagg cacaagggag cttgactgcg agacctacaa gtcgagcagg gacgaaagtc 170221 gggcttagtg atccggtggt tccgcatgga agggccatcg ctcaacggat aaaagctacc 170281 ccggggataa caggcttatc tcccccaaga gtccacatcg acggggaggt ttggcacctc 170341 gatgtcggct catcgcatcc tggggctgta gtcggtccca agggttgggc tgttcgccca 170401 ttaaagcggt acgcgagctg ggttcagaac gtcgtgagac agttcggtcc ctatccgtcg 170461 cgggcgcagg aaatttgaga ggagctgtcc ttagtacgag aggaccggga tggacgcacc 170521 gctggtgtac cagttgttct gccaagggca tcgctgggta gctatgtgcg gacgggataa 170581 gtgctgaaag catctaagca tgaagccccc ctcaagatga gatttcccat tccgcaagga 170641 agtaagatcc ctgaaagatg atcaggttga taggtctgag gtggaagtgt ggcgacacat 170701 ggagctgaca gatactaatc gatcgaggac ttaaccatat ttttgaatga tgtcacacct 170761 gttatctagt tttgagagaa cactctcaat ttgtttggtg gcgatagcga agaggtcaca 170821 cccgttccca taccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt 170881 ccccctgtga gagtaggacg ccgccaagca attgcacatt agtgtaattt tttaaaaaag 170941 ttattgactt tgaagaagtg acattgtata ctaataaagt tgctttaaca aagcggacaa 171001 acaaaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca gtttttaaaa 171061 atcgcacagc gatgtgcgta gtcagtcaaa ctactttatc ggagagtttg atcctggctc 171121 aggacgaacg ctggcggcgt gcctaataca tgcaagtcga gcggacagat gggagcttgc 171181 tccctgatgt tagcggcgga cgggtgagta acacgtgggt aacctgcctg taagactggg 171241 ataactccgg gaaaccgggg ctaataccgg atggttgttt gaaccgcatg gttcaaacat 171301 aaaaggtggc ttcggctacc acttacagat ggacccgcgg cgcattagct agttggtgag 171361 gtaacggctc accaaggcaa cgatgcgtag ccgacctgag agggtgatcg gccacactgg 171421 gactgagaca cggcccagac tcctacggga ggcagcagta gggaatcttc cgcaatggac 171481 gaaagtctga cggagcaacg ccgcgtgagt gatgaaggtt ttcggatcgt aaagctctgt 171541 tgttagggaa gaacaagtac cgttcgaata gggcggtacc ttgacggtac ctaaccagaa 171601 agccacggct aactacgtgc cagcagccgc ggtaatacgt aggtggcaag cgttgtccgg 171661 aattattggg cgtaaagggc tcgcaggcgg tttcttaagt ctgatgtgaa agcccccggc 171721 tcaaccgggg agggtcattg gaaactgggg aacttgagtg cagaagagga gagtggaatt 171781 ccacgtgtag cggtgaaatg cgtagagatg tggaggaaca ccagtggcga aggcgactct 171841 ctggtctgta actgacgctg aggagcgaaa gcgtggggag cgaacaggat tagataccct 171901 ggtagtccac gccgtaaacg atgagtgcta agtgttaggg ggtttccgcc ccttagtgct 171961 gcagctaacg cattaagcac tccgcctggg gagtacggtc gcaagactga aactcaaagg 172021 aattgacggg ggcccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 172081 accttaccag gtcttgacat cctctgacaa tcctagagat aggacgtccc cttcgggggc 172141 agagtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 172201 cgcaacgagc gcaacccttg atcttagttg ccagcattca gttgggcact ctaaggtgac 172261 tgccggtgac aaaccggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgacc 172321 tgggctacac acgtgctaca atggacagaa caaagggcag cgaaaccgcg aggttaagcc 172381 aatcccacaa atctgttctc agttcggatc gcagtctgca actcgactgc gtgaagctgg 172441 aatcgctagt aatcgcggat cagcatgccg cggtgaatac gttcccgggc cttgtacaca 172501 ccgcccgtca caccacgaga gtttgtaaca cccgaagtcg gtgaggtaac cttttaggag 172561 ccagccgccg aaggtgggac agatgattgg ggtgaagtcg taacaaggta gccgtatcgg 172621 aaggtgcggc tggatcacct cctttctaag gatattatac ggaatataag accttgggtc 172681 ttataaacag aacgttccct gtcttgttta gttttgaagg atcattcctt cgaaacgtgt 172741 tctttgaaaa ctagataaca gtagacatca cattcaagta atacaagata tcacatagtg 172801 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg 172861 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga 172921 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata 172981 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc 173041 aaatgcgatt ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc 173101 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt 173161 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag 173221 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc 173281 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag 173341 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc 173401 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat ctcgtgcaag 173461 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt 173521 ggtcgtagac ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg 173581 aatggaggcc cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga 173641 aatgccaatc gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca 173701 aggtaagagt cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa 173761 ttcagtcaaa ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga 173821 tccgtagtcg aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag 173881 tggaaaagga tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt 173941 taaagagtgc gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta 174001 aacgtatcac cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc 174061 tgtgaagcca gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta 174121 gcgaaagagg ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt 174181 ccgctcaggg ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg 174241 ttgatattcc tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg 174301 taagcgcggt attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt 174361 tcccataagg ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca 174421 ctgccaagaa aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag 174481 gcgaggagag aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac 174541 cccgtaactt cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga 174601 ataggcccag gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta 174661 taggggctga cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg 174721 tgcgaattga agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat 174781 tccttgtcgg gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac 174841 gagagactcg gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa 174901 agaccccgtg gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata 174961 ggtaggagcc ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc 175021 tggctgtatt gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg 175081 cagtttgact ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag 175141 aatggttgga aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac 175201 aagtcgagca gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat 175261 cgctcaacgg ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat 175321 cgacggggag gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc 175381 caagggttgg gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag 175441 acagttcggt ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg 175501 agaggaccgg gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg 175561 tagctatgtg cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat 175621 gagatttccc attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg 175681 aggtggaagt gtggcgacac atggagctga cagatactaa tcgatcgagg acttaaccat 175741 atttttgaat gatgtcacac ctgttatcta gttttgagag aacactctca atttgtttgg 175801 tggcgatagc gaagaggtca cacccgttcc cataccgaac acggaagtta agctcttcag 175861 cgccgatggt agtcgggggt ttccccctgt gagagtagga cgccgccaag caagcttaaa 175921 cccagctcat tgagctgggt tttttgtttt atatctgtgc cgatttgctt tcgtcagtat 175981 ccattttatc aagcttctgc tttttaaagt tttctaatac ttttgaattc caatacaatc 176041 cctagcatga tcaacatgag agtcataaat aatcaaaatg cagtttgtac gggagactca 176101 tccagactcc atccgactgc gattggcagg atagagccgc caatccattg gcagcgaaca 176161 gcatgcttgt cgtttgttct gtttttccat gataaaattg attggtgaca ataaaataat 176221 ggcgaacatg ccggccataa ataagtccta agaaaaaact aagaataatc cctgcaaaag 176281 ctgttttatt gattgccaaa atacagagtt aaatgaggcc gctcatattt atcagcctga 176341 gataatgatg ataggttatt ttttcggaaa ccagctcggg ttgccaaatg agagaaaaga 176401 tattactgtc attaaaacga ttcttggttt catccggata tgataaaatg tctcagacta 176461 tatttgagcc atttttttct tcagcaatca tcttgcgtaa ttgataaaaa tttattatga 176521 tactctttgt atgacaactc cttgcctcaa tacaatatac tcaacgtttc cccgttttct 176581 ccggtcgttt ttcttttcat tttctcccgt aaaataaaaa aagctcccaa tacaatagat 176641 atggtgcgga tttatttttt actaaaaagg agtcgttata tttgaataat agttttacat 176701 taaaacagca atggttcggg aatatccgaa aagacattct tgctggcatt ttagttgcgt 176761 tagcgttaat acctgaagcg attggctttt ctattatagc cggtgtggat ccgatggtcg 176821 gtctttatgc gtcattttgc atagccatta ttatttctat ttttggtggc agacctggca 176881 tgatttcagc tgcgacaggc tcaatggcag tcgttatggt gtcgctggtt gctgatcatg 176941 ggcttcagta tttatttgcg gctacgattt tgacaggcat tattcaggtg attttaggta 177001 tcagtaaaat tgcaagatta atgaaattca tcccgcgttc tgtgatgatc gggtttgtga 177061 atgcgctggc gatccttatc ttctctgcgc agcttcccca gtttgaaggt gcttcttgga 177121 gcatgtatgc gatgcttgcc gggtcgttgg ttattattta tgtgctgcca aggtttacga 177181 ctgctgttcc gtctccgctt gtggcgatta ttgtgatgac aattattgcg gtcactttcc 177241 atgtggatgt gcggacggtt ggtgatatgg gcaatatttc tagttcattg cctcatttct 177301 taatccctga tgttccgttt acctttgaaa cactgcaaat tatttttcct tattcaattg 177361 ctttagcgtt tgtcgggttg cttgaatctt tgctgacagc acagattatt gatgaaatga 177421 cggatacgga tagtgataaa aataaagaga gccgcggaca gggaattgcg aatatcgtga 177481 ctggattctt tggcggaatg gcaggctgcg ctatgatcgg acaatctgtc attaatacaa 177541 aagcgggcgg tcgcggacgt ttgtcagcat ttgttgccgg tgcttttctg atgtttttaa 177601 ttgcggtgtt aagtcatgtc gtggtgaaaa tcccaatggc ggcgttagta gctgtaatgg 177661 ttatggtgtc tgtcggcact tttgattggt cttctttaaa aggtctcaaa aaagcgccgc 177721 tcacggactc gattgtcatg gttgtgactg tggttacggt tgttgtgacg gatgacttat 177781 ctaagggtgt atttgtcggt gttcttttaa gtgccgtgtt ctttgtagca aaaatctcga 177841 agctgaaaat cgtttctcat gcagaggatc aaaagcttag aacgtatcaa gtgaaggggc 177901 aaatcttttt tgcgtcagtg actgatctta cgaatgcgtt tatatatcaa gaggatattg 177961 agcgggttgt gattgactta actgaagctc acgtatggga cgattctggt gcggccgcac 178021 ttgataagat tgttgcgaag tttaaggaac aaggcattga agctgagtta aaaggtttga 178081 ataaagcgag taaatctcta atgaaacaga tggcataaaa tagagaagcc cagatgaatg 178141 agatctgggc ttttttatat aacatacact taagcagcat tgatataata gagagaagag 178201 aaattttaaa taggggactt gcatatgatg cttcagaagc tgaaccgtgt attggggaga 178261 gtgatgccgc tgttaacgcc gactagtgtg gtgctgggcg tgctgctgtc tcagttttta 178321 aatgggtatg aatgggctgt gccttggatc tttgctttta ttacgtttgc aggcagtttg 178381 agcgcgaact ttcaatcttt gagacatgca ttgtctcatc ctctccctat gattcttgca 178441 ctattcgttc ttcatatttt catgccgctt tttgcttggg gcagcggcca tcttatattt 178501 aaaggtgatc ctttgacgat taccggttta acattggctg ttgtgattcc tacggggatt 178561 acaagcttga tttgggcagc gatgtacaaa gggaatgtcg gtttgacact ttcgattatt 178621 ttagttgata ctgtgctgtc accgctaatc gtaccgctga gtctttcatt gctggccggc 178681 gctcaggttc acatggatgt gtggggaatg atgaaaggtc tgattgtaat ggtcgtgatt 178741 ccttcttttt tgggcatgct gtttaatcag atgtcatctc cagaaagaac tgcgtttgtg 178801 agcagtgcgc tgtcgccttt ttcaaagctt tgcttgatgg cagtgattgc gattaacagt 178861 tcagcgattg ctccttattt caaatccatt gatttgagat ttgcaggaat agctgtaacg 178921 gtattcttta tcgcgttaac aggttatgcc gctgcttggc tgatcggaaa aatgatgaaa 178981 aggcggcaag aggaaatagt ctctcttata tttacgggag gcatgaggaa tattagtgcc 179041 ggcgcagttc ttgccgttac gttcttcccg tctcaggttg ccgttcctgt tgtgatcggc 179101 atgctgtttc agcagatatt ggctgctttg tttggctata tgctgaatcg ttttgaatta 179161 aaaccaatgt tgcagaaggc ataaaaaaac cgctcatagg gttgagcggt tttttccgta 179221 tagccattcg agcgcgttga tgaactgttt gcagaaatac ttgtggtggt gcaccgctcc 179281 tttttcaatt gaaagacaca actggtcttc agtgaagcct ttttctttta gactttgatg 179341 aacttgcttt gtttttttca gcatatgtcg ctgaatggat tgtttttcac ggccttcttc 179401 actcccgata gacatgaaaa cacgtgcagt gccgggcttt aaagaagata tatgaatggt 179461 ttccgctgcg ttctcgtacc agtatgaacc tgatatagag cctattttcc cgaacattga 179521 cggatatttt aatatggcga acattgagat gaggccgcct aatgaggcac cgatcattcc 179581 tcttgactgc ggttccctgg tgacgttcca gttttcttcg attagcggaa tgaactggtt 179641 cgttatatca gacagatagt gatatcccat tccgccgaag tccgtgaacc gatcactgag 179701 tgatgcagcc ggccatgggg tgtattcatc aagccggttt tcgggttcga taccgatcag 179761 cacgagttca gggagccttt gctgttgaaa ggcgctttct agtaattcga tttggttttg 179821 gaacaaagaa ctgccatcct gcacgtaaac agcaggaaat cccccgctgt ctgtgctgta 179881 ggaaggaggg aggtacagcg tgaacctcct gttgccggct ttgtgttctg aaagagatcc 179941 tttcaagcat tctccccctt tttttgcttg aaaagcagat ataagaaata aggaactccg 180001 aggatcgcca aaatgatgcc tgcgggcact tctgcgggct gaaaaaacag ttttccggca 180061 aagtctgcgc ttatcacaag aagcatcccg attaaaccgc tcagtggcag gatatagcga 180121 tgttcgacgc cagccagtct ccgtgagata tggggagcaa ttaagccgac aaacgccata 180181 cttcccgcta cggagacaca ggcgctgatg attgctacac aggcaacgag aaggatggtt 180241 ttttctttat ttgatgaaat accgaggctt ctgactgtgt cttcatcaaa acgaatggtg 180301 tcgagcaggc gggatttgcc gataagaatc ggtataaaca gcagcatcca tgggagtaca 180361 gctgtaatat acgtccagtt ggcagaccag atgcttccgt ttttccacac catggccatt 180421 tgatagtctt gcgggtccat ttttaaagat aaaaacaaag acagggcgct gaatcctgaa 180481 ttgatcgcaa tccctaccaa aataattctt cctgaatcta aattgcctct gtgccatgca 180541 aatatgtaaa tcaggatcgc cgcgatgagc ccgcctatca atccaaagag cggcattccc 180601 atcgctgcag ctatggatgt cacttccttc tggccttgga ataagagcat aaacgctaca 180661 atgccagctc ctgcccctgc gttgattccg agaattccag ggtcagcaag cccgtttctc 180721 gtgatggcct ggataacagc gcctgcaatg ccaagaccga gtccaataat agcagccatg 180781 acaacccgcg gcagtcttaa atcgaacagc aaaatttcat actgcggatt cgggtcgatt 180841 tgaaaaagag tggagagcag ctcagcagga cgaacagaaa atgatccgct cgttaagctg 180901 aaatagctga caacaagaat caaagcgatg aacaatgcat attttttagc cattttgctc 180961 ccctcctttt cgtttaatta aataaaggaa gaaaggtacg ccgataatgg atgttacgac 181021 ctcaatcggt gtttcaaacg gatagttgat aaatctgctt gcgagatcac acagggttaa 181081 aaagattccg cccaaaatac aggaacacgg aatcagcctg ctgtaatcag agccgacgag 181141 aaatctcgtg atatgcggaa caaccaaccc gacaaacgca atttttccgg ccagcgctac 181201 ggcactgccg gttagaatga tgacggaaag catcgccatg attttaatgg tttttttctt 181261 ttgccccagg cttttagaaa tgtcgtcccc taatgataca gcggttacct ttttgctgag 181321 agaaatggcc attataatgc caatcaggaa aaacggagcg gcaagcttca ggaaatctgg 181381 actcatttga tgaagtctgg cactgtacca gaaactgaga tcctgagaaa tttgaaaata 181441 aatcgacatg gccgctgata agctgctgag cagcatgctt gtgactgtgc cgatgatggc 181501 gagctgcacg ggggtaaatc cgtttggcat catggcggca aggccgaata ctaacaccgc 181561 tcctaacgct gagccgataa aagagtatat catcatttca atcgaagatg attgcgggag 181621 cagaaccatg caaagcgtaa tgataaacgc tgaaccatct gaaacaccca taatggatgg 181681 cgaagctaaa taattgcgcg taatgccctg cataagcgct ccagaaacag caagggctgc 181741 ccctatgagc agagcgccgg cagcccttgg aatccgggaa tgccatataa tttgatggtc 181801 tgtgtttccc ggatcgaaat gaataagaga tgtaaaaaca atatctgtgc tgagatgctt 181861 tgccccataa aggattgaaa gcaaaagtga cagcgctata gcaaatggag aagtaatcaa 181921 tatgatacgt gtccactgtt ttgaatacat acaaaaacct actctgaatt agttttgtgt 181981 caatttttca gcagccgctt tcaggaaacg gactttgctc caagctgtgc cgccttgtgc 182041 gagagggtcc actgagttga catacacatg gtcttctttg actgctttaa ggcttttcca 182101 gattggattt ttctctaaat cttttaaggc atcaggtttg tctgcatttt catcatcaga 182161 aaattggacg aaaatatggt ccgggttcat ttcacttaat ttttctaatg aactcagctc 182221 ttgcgctttt gcagccttta cttcgttcgg cgccttaagg cctaaatcac cgtatagtgt 182281 ggagttgaaa tacacctgtt cagggtaaat gtaaatgttg ccttgtctga ttctgatgac 182341 aagcgctttt gaatctttcg ctttatcgtt gatttttgtt tttatttctt ttagatcctg 182401 ttcatagtct gcaataattt tctttgcttt tttctctttt ccagtcagct gggcaagaag 182461 catcatgttt tccttccagt ttgaagagat atgagaaact gggatcgtcg tgcctgctgt 182521 gctgattttt tgcagcgttt tttccggaaa ctttgttgaa gcaaggataa catctggctt 182581 catttcaaga atcttttcaa tatttggctc cattttttct ccggttggtt cggctttatc 182641 agtgatgtct ttgaacatat cagggaattt gccggagaat gaaattgcgc cttgcggatg 182701 aacgtcaagc aatttcgcgt cttccattga ttcaacgctt cccgtaatgg caattttgtc 182761 tgtcggtaca gttacttcat atgttttatc aaggtattca attttcttct tctcagatgc 182821 tgtgccgctt gccttgctgg cagttgattc atttttgctg ccgcaagctg ccgccgtcag 182881 cgcgagaagt aagattaata aggtaagaga tatctttttc atctatagag cctcctgttc 182941 aattgataac tattatcaat tggaattata gagaatgaac agatataaca ccatggacaa 183001 attcctgatt tatcatggac aatctccgga tagtaaagaa acagtttgct gaacgatgcg 183061 ttcgtgcccg caagctgagt attcattcca cgggtcaagg gatagaagat aaacacggtt 183121 atctcgtacc gcgcttaggt tttgccatgc ttctgtctgc tgtaattgct ggtagtaagc 183181 tatggtctcc ggctctttaa aaagaaaaag catcatacag tcagcttggt aatttgcgat 183241 attttctaac gaaatcgctt gttctgaagg tgtgtcagcc gttgttgccg agctgaatcc 183301 taaatcccca aagaaaactt cgcggacact tcggttatga gccagataga agttttgctt 183361 atgcagcctc aaaaagagaa aacgcagccc ttgaacgtgc tgaagtgttt ttttggcggc 183421 cgttgtctgc tggtcataat ccgctagcca cttttctgct tcggactcct cctttaaaaa 183481 tgaggcagtt tgcagaaagt gggttctcca gctttcttct gaaggaaggt acatgacttc 183541 tgcgatgcga ttcaggcgat cttgttcttc tggagaaata gaatccatgc tgacaatcac 183601 atctggttct gcctgtgata acgtgtacag gttttcttcc cacttttcat taaaccggta 183661 tgcactgagc tggacgggta tatctgtcga ataatgctga tagtagtaag acgtccattt 183721 cggatgcaga gcggccgcaa aaggtatgtg gtgaagaggg atgagatggc ccattgtgcc 183781 ccttccgtat gcggcgattt tctttcggcg ttttttcata tagcttgtag gtgaacagcc 183841 tgtatatttt ttaaagattc tgctgaaata aaattcatct tgataaccgg tttggtgtgc 183901 gatttctttc aatttgcagt ttgattttgc catgagccgt tttgcctttg tgattcgtgt 183961 tttcgtaata aattctgtta cgctctgtcc tgtccatttt ttaaagcttt cactgtagtg 184021 tttggcactg attcctgcca tttgcgacag ctgggcaagc gtgatttttg tatcggcatg 184081 ggtttcgata tagtgttttg ttttttcgat tgctgaatgt gtatccgttt gatcagataa 184141 actggcagta aaaagatcat aaatcaggct ttgtacttca atcacacatt ttagctgaga 184201 aagctgagac gattcattcc atagtgcggc aagctcttga agccggactg caagattttc 184261 gatatgtgaa acattcataa gcttcagttt ggctaattcc gattctgtgc acggtgtgaa 184321 aatatcttgc ccggtttcct tgatatagct tagaagcctg attatacagg catctatatg 184381 tccatcggct gctggcgtaa agccaaaggt ctcgttaggc ggacaaacat aaagtgtctt 184441 tttttgcaga ggattggtgt ttgttccgat cgaaatatag ccgtttcctt ttaaatgaaa 184501 aatcagcacg aatgaatcgg ctaattgctg ttctgagaag agatcacttg tcttttttag 184561 atattcaatt tgtactggtt gataaatcac tgcattttgc acgagtagac caccttttca 184621 gaagctttca attgataatc attttcaata aaaattgtac caaataaatg aaagttttcc 184681 tatataaagc gggtgggttt ttagcatgaa aaaaaccctt acttatgtgt aaaagtaagg 184741 gtctttcgtt caataagaat atgttacacg tgtaacatac gatgcttatg ttctaataaa 184801 tgagatactt ttttcttgtt ttgctgaatt gttggagtgt tttttcatag ctgtttatga 184861 tgttctcaac cgaagttcca ttttcaattt ttgtcctgat ccagccgttg cctgccagtt 184921 tatcgaatga acctgttgac aggaactcaa aatcctcagg atagagatcg tgtatggttt 184981 taatgactga aagacccgtt ttaacggctt caaacttatc tctgtctgtc acatagagct 185041 gcacaccgtg gcaaagcgtt ccttgatgtt tagaaaacgt cggtgtgaag gatgctgccc 185101 taaatgtaac gcccggcaaa tggaggctgt ttaatgtttc ttcaagttct gtgcttttga 185161 taaagggagc tccgatcaat tcgaatggct ttgttgtccc tcgcccttcg gatatatttg 185221 ttccttcaat cagcccggtt gcaggataaa caaatgtgct ttccaccgtc ggcatgttag 185281 gcgaagggag gacgaaaggc aatcgggtat cgtcaaaatc catttttcgt ttccagtgtt 185341 tcatttttac cactgtaaga tcggcatcaa tactaaattc tttgttgaac agtgaagcca 185401 attcgcctat cgtcatccca tgcttcaatg gaatgggata caatccgaca aatgaggcgt 185461 attcaggttc taagattggt ccttcaatat gattcccgcc ttgaggattc ggacggtcca 185521 gcaccataaa tggaatgccg ttttctttag cggcttccat tgcgtatgcc attgtataaa 185581 tgtacgtgta gaaacgggtc ccgacatcct gaatgtcaaa cattagaata tcgacatttt 185641 taagcatttc tggagtcggt tttttcgttt ttccgtagag gctgtatacg ggaaccccgg 185701 ttttttcgtc aatgtaagag cctacttcgt ctccagcctg ggcgtcaccg cggacgccgt 185761 gttcagggcc gaataaagct gtcagtttga tatccgggtt ctcgtaaagg atatcgacac 185821 tgctttttag agatgtgttt actccggctg gattggtgat cagtccgatg cgttttccct 185881 tgagctgttt tttatagtct ggcaagagcg tgtctatccc agtctggact ttaggttttt 185941 tagctgtttg attctttgaa tcgggtgaag cagaggcagc ggttatcgtt ccgaacatca 186001 tgagccctgt cagaaaagcg aatattgttt ttctcatgtg tccctcctta ttaaagcggt 186061 cttcccgttt tgatatttaa tccgtagcca agtgggtaaa gggtgttccc tggtttcgtg 186121 actgacggaa tgtcaactgg aagtgtgcct ttaggttttg cctggccgaa tatcgccatc 186181 actccggccg gaatattagg ttgaagataa cggccatttg cgtatccttt aaagccatag 186241 actgcaatca gtgcttttgc ttcttcgaaa ttggctgcgt cataggggtt gcgcaggctc 186301 attaagacaa atggtttgtt gtgctgcagt gcggctttca tgacagctct cggaaacacg 186361 gtggcccatt tgcttgaatc tgatattgtg tcgtcgatga caccgtcgtt gacgacaggg 186421 tcatttttga cgacatagga gccggtaatg atataatcag cctcttttac ttgtttttca 186481 tgctcggtct taaatacttg gctggcaaag ttcattttgc tgagggatac gggtttgatt 186541 ttctttcgct tgatgagatc gtgaatggtt tgttcgattg aagcagtttg ttcttcgtaa 186601 ggtgccacaa ttaagattcg gctgcctttt ttaggcttga acggcaaagt gtgctgttca 186661 ttttttaata cagttactgc tttttcagct aattttttct ctgctttcag gtgctgcttg 186721 cttcctacga tttttttggc tttggctatt ttttcttttg tactgtcgct gtttcgcgct 186781 ggatacatgc cgcgttttat tttcagggaa atgattcttt caactgaatt gttgatttgt 186841 tgttcaggaa tatccccgtt tttcacggct tctttcaaag cttgaataac acgtgcgaat 186901 ttctgttctt ctttcaatga agtgactgag gctggcatta atgcaatatc gacaccagct 186961 tttacggcca tgaccacagc ctcttcctgt ccgaaatgat ctgcgattgc cttcatattg 187021 agcgcatcgg taacgatgac cccattaaag cccatttcct gacgaagaag acctgtcatc 187081 actttttttg aaagtgtagc tggaaccaga atgtccgatc catcgagttt gcttttgtaa 187141 gtggtgtcat caaaggcggg aaactgaaca tgggctgtca tcaccatatc agcaccagca 187201 tcaattgctt tttgaaaagg ataaagctcg acctcacgaa gccgttcttg gccatgggaa 187261 acgagcggca gtccataatg gctgtcaacg tccgtgtctc catgtcccgg gaaatgtttg 187321 agggcagacg cgatatcctg ccgctgcaac cctttcatcg tatataaacc gaggcgtgat 187381 gtcagttctc gattggagct gaatgaccgt acgccgatta caggattatc aggattattg 187441 ttaatgtcca cgacagggct gaaatctgta ttgatgccta aggcagagag ctcttttccg 187501 atgatgctgc cggtctgata cgcattgatt ctgcttctgg ctgcgcccag cgccatattc 187561 cctgggaaat tagtgccctc ccctaacctc gttacaatgc cgccttcctg atcaatactc 187621 agcatgagcg ggatttttgg acttgccttt tggtaatcgt ctgtcagttg gacagtttgt 187681 tttgttgttt ttacattttc tgcaaaaagg atgatgcctc cgaattgata tttcttgacg 187741 aggctggcga cttcatcatt catttttgta agggcttgcg gagaggactc gccttccttt 187801 tgccaatttc taaaatcagg catcagcatc tggccgagtt tttcatctaa cgacatacga 187861 ttgacaatct gattggcatc gattgcacgt ttggatgcag aggcttctgt ctgtctggcc 187921 ccgaaaaagc atgaaagaaa gagaacggct gaaaggataa gcggaaagac aggtctcata 187981 gaaacttcct cctatcgtct aatcattcac tccatcgctt cataaatcgc ggttatgaca 188041 cttccataac tgcctgttgg aaattggtca ccttcaaaga cgttcggatt ttcttccgga 188101 tcaataactg gtgtatgctt tttatttgtt aacaatgcga tgcctaaatt gtatgctgga 188161 tcaataattg taactgtccc cgtccagccg gtatgcccgt aagcattttc gctggcatga 188221 gggccaaaca tccattccat gcttttactt ccgttccgcc tccagccaag agcgaatgtc 188281 ggatctgttg ctgaaggtgc tgtaaacagg tcggctgttt tctgatcaaa taaagaaatg 188341 tttcggtatg aacctttgtt taacatgact tgcagcagta tggccatatc atctgcattt 188401 gagaacaatc cggcatgccc agacacgccg tccattgagt aaaacgcttt ttcgtcatgc 188461 acctctcctt gcagcgtgtt tgtgcggatg ttagggaatt gaataacgcc gtcacgtgta 188521 ttgcccatgc gttcagtagc tgcgaactgt ttcggtttaa agcccttttg cagcggattg 188581 tacaaggtat gcttcagcct gagcggtttg tagagctctt gctccgtgta gacatcaagc 188641 ggtttgccgg tgagtttttc gacaatacat ccgagtagca tatatccaat gtcactgtat 188701 acgtgttttg tcccggtttg ataatcgagc ggaattttcg tcaaatattc aatcgttttg 188761 tcccgttctt gggaatagta cttgccggct ttttccggcg tgtaaaagta aaagcttgat 188821 gggagccctg attggtgctg gaggacatca atgacacgta tcttgtcttt tccttttatg 188881 aggtcacccg gctgatcctt gaaacccggc aaatatgcag aaactttttc atagacgtca 188941 agttttcctt ggctgactaa gcgctgcaat gcaaaatttg ttgcgtacat ttttgtattt 189001 gaggctaagt caaacatcgt gcgggttttc attttggccg gacggcgcag cagttctgat 189061 ccttcgtact ttttactgta gccgtatgct gcttttttta tgatgcgtcc atccttcacc 189121 accacaagaa cggcgcctgg aaatcctgct gcaatatccc gttctatcat ctgatctacc 189181 ttccttagct tcttcgtcga gaattgtgca gtttctgcat ttatgatttt cggctcaatc 189241 aagttgcctg ctgtttgtgc gaaggtttca tttggcgcaa atatcgatag ggttaaaatg 189301 gcactgaata tgaacagtgt ctttgttttc acaggctagc ccctttctgt gcttctatcc 189361 cgtttactat ccctaaaaca gaaacaattt aatcgaactg agaagccatt tcatctttat 189421 atccgaatgc ataggtcaat aaaaaaccgg ccgcgtagga aataaagagc ccaacgatat 189481 acaggatgat ttgcgaaggc aggactagaa aagatagcgg cagtccggag acaccaatcg 189541 caatggtggc tacttgaaaa taagcttgaa aggcgccgcc gattccagct cctaaacatg 189601 ctgttaaaaa cggacggcca agcggcagcg tgactccgaa aataagcggt tcaccaatgc 189661 cgagcagtcc cgatggaagc ccgccggcga ttgctttcct cagtgttgtt tttttcgtct 189721 tcacgaaaac ggcaaaggcc gcgcctacct gtcctgcacc tcccatagcc aaaataggga 189781 gcagaggatc attgccaatt gaattgatca gttccatgtg cacaggcgtc aagccttgat 189841 gcagtccggt tacgacgaga ggaaggaagg ttgcgcccag aataaagccc gcagcgatgc 189901 cgccgatgtc caggatggac agtaggccgg atgtaatagc atcagaaatg aatccgccta 189961 aaggcataaa tacgacatac gttacgattc cggtgattaa cagtgaaacg gtgggtgtga 190021 caatgatatc aagtgattga ggaataaaac ggcgaataaa ttgttcggtg taagcaatga 190081 atatggctgc gaaaaggacg ccgatcagac ctcccctgcc cgggagaagc tcttctccaa 190141 ataaactgat ttttgcgatc tccggattga taatcaagat cccggccaaa gccccaagtg 190201 cgggtgtccc gccaaattct ttcgaagcgt taataccgac gagaatgccg agataagtga 190261 acagccctga tccgatgact gtcaggataa tcgcaatttg tgagtctgca gagagccagc 190321 ctgcttgaat aattgctttg gtaatcccag taattaaacc ggaagcgact agagcgggaa 190381 taagagggat aaaaatgctg gcaattttac gtaagaaaag tttaaaagga gtggcatttt 190441 tccgattgat atcggctttc tttttggccg ctgcttcttt gacatcggca ccttcttctg 190501 ctgacacgag ctttgagaaa gcagctgtaa catgattgac aactcctgtg ccgaggataa 190561 tttgtaaggt ttcagcttca acgaccccca atacgccgtc aagctttctt aaagcctgag 190621 catccgcttt gctttcatcg taaggcgtaa tgcgcaggcg tgtcatgcaa tgcgtatatg 190681 aagaaatatt ggattttcct ccgcatagct caaggatttt ctgtgcgaga tgatggtagt 190741 tattttcttt gctcattaaa acccctcccc ttcaagatgc cttattttat tctcatagat 190801 tgtatggctg ctctcgtttt atctatataa ccggttgtcg tttcatactg ctcagccgcc 190861 atgcctaaaa acaaaacatc aattataaaa agctgggcga ggcgggaaga agtggctgca 190921 cttcgaatca aggcttcatt ggaatgggct gtatacaaag ggacatcagc cagtgcggag 190981 acggatgtct gactgaattg tgtgaggctg atcgttgtga tgcctttttc cttagccatg 191041 gcgaacagtt caacgatttc ctgtgtctct cctgaaaacg aaatggcgaa tacgatgtcg 191101 tctttatctg catttgcgat taaagatgcc acaagatgag tgtctgtaaa cgcggttgct 191161 tgtttatgaa tgcgaagcca cttttgctgg gcgtccttgg cgacaatgcc ggaagccccg 191221 aggccgataa aatgcacggt atgagctttg agaagcagag aaaccgctcg ttcaagctct 191281 ttgtagtcca tcaggtctga agtatcctga atggcttgaa tggcattgcc ggccgttttt 191341 tcggaaatgg agggcagcgg ctcgtgggga acaatatccc ggtagccctg aaacgtaggc 191401 tttgccagat cgcctgctac tctcattttt aaatcttgaa atccttttaa accgagtgat 191461 ttgcagagcc tgatgacggc agcgtcactt gaattggcta aggcgctgat ttcgttgacc 191521 gtgctttcga ttgctttgtg gggatgggct aggatataat ctgcaagttt gcgctcggat 191581 ggagggagct tatgcttcat tgattggatg atcgctaaac cgcctgtggc cattctagtt 191641 ctctccttat catggatggt aatgttcgat tgctttgtca atgaaaccgt ttgcttcatc 191701 gagtaatgtc tgtgcttgtt tctgatctgt gcttgttttg agcatgacga ttgctgtttt 191761 gacgtgatga tcggcttgtt ccagagtgta tctggctgtg tcgtatgaag cgtttgtaag 191821 gctttggatg atgctgatgg cgcgttcttt tagttttttg ttgctgacgt tgacgtctac 191881 catcaagttt tcgtaaacct tgccgatttt gaccattaca gcggtagata tcatgtttag 191941 aatcatttta tgagcggttg cggctttcat acgtgttgat cctgtaatgg cctcaggtcc 192001 gacgacaacc tcaatgctgt gatccgcatc cttgctgatg gcggaatttt cattgcaagt 192061 aagggcgatg gtgtgtgctc cgactttacg ggcgtatctt agggcgcctg cggcgtaggg 192121 tgtgcggccg cttgctgcga tggcaatgac ggtgtcattt gaagtgagct gtatgtttct 192181 taaatcttca gctcctgctt cttcactgtc ttcaatgccc tctgctgcct gtaaaaaggc 192241 ttcggggcct ccagccatga ttccgatgac ctgatctggg cttacgctgt aggtgggagg 192301 acattcaaca gcatccatga cgccgagtct gccgcttgtg ccggcgcctg tatatatgag 192361 ccggcctcca ttttgaaacg attcatatgc gcagtctaca gctgttttga tgtcggggag 192421 aacctcctga acggctgcag cgactttcat atcttcgttg ttgatcattt taaggatgcc 192481 gagagtgttt gctttgtgga tttcaactgt ttgactattg cgtgattccg ttgtaagacg 192541 gtgaaggttt aatggttctg acatgaggat gccccctgtt ttaaaatgat atatctcaat 192601 attcagtata ttcatttctg ttatgatatt tcaactatgt ttttaaattt ttgaaatttt 192661 atttcactta agactataag aaatgatgaa ggatcaactg ttctccaagc ggcccgattc 192721 ttcgccgtcc tttatcaagg aacccgcttt tcatataaag gtgttttgcg cgtatgttca 192781 gatgattgac ggccaagatg atttcgtcgc accatggaaa atatccgctc acaaaagcgg 192841 gaagcaaaag catggctttt ttcgcatagc cttttccgtg atgcacagcg gttaaagaca 192901 gggagctgag cagtaaagca aatggattgt tagaatagga agcaagcgtt tcttttgatg 192961 catgtaaaat gaaaaaaccg actggaaggt cgtcttttaa gatgacaacc gggtatcggt 193021 cctgtatgcc cagagcctga gacagcacct ctttcgggag ggaggtaaag cgtttgtcat 193081 cgttggtgag cgtgaatgat tggagctcgg gcaagtgttc aggcttatag aaggataaag 193141 aaatgtcttg agtcatgggg tggcctcctt acaatatgtc gttaagctcg ttttccgaaa 193201 tgacgcggta gcccgcttgt tttaacagtg cggcggttac tccgctgccg gtgatttttt 193261 tgccagagaa tgtgccgtta tagataaaac cgcttccgca agatggactg ttttctttta 193321 atatgacggc agaagcgttg atttcttttg cgtaagccaa tgttttcgcg gcgccttcca 193381 tatatagttc tgtgacgtct tctcctgaag ctgtcacgat tttcgctgtt ccattgagga 193441 catcctcgcc agtgcctcct atgatttctg cgggttcgcg tggggtagag aagccgccga 193501 gaagttcagg gcaagccatg actgctttct tttcatcgac tagttttctg attttctccg 193561 acgctgcgtg agagccgtta tatctgcatt caatgcctcc aaggcaagaa ctgactagaa 193621 tcatattggt ttctcctctc ttgctttgct tgtctctatc ataaaataaa tggctttagt 193681 tgggaggctt tttcagttaa aaaaggagtt aaaaagtttg aaaataaaaa atttaatttt 193741 cctctttaca aacagggggt gacctgtata taataacttt tgtcagctcg acgagaacac 193801 aacggcccgt tggtcaagcg gttaagacac cgccctttca cggcggtaac acgggttcga 193861 atcccgtacg ggtcaccatt tggaggatta gctcagctgg gagagcatct gccttacaag 193921 cagagggtcg gcggttcgag cccgtcatcc tccaccatct tgccggtgta gctcaattgg 193981 tagagcaact gacttgtaat cagtaggttg ggggttcaag tcctcttgcc ggcactgttt 194041 tttcaaaatt ttatgtggag gggtagcgaa gtggctaaac gcggcggact gtaaatccgc 194101 tccctcaggg ttcggcagtt cgaatctgcc cccctccacc attattgggc tatagccaag 194161 cggtaaggca acggactttg actccgtcat gcgttggttc gaatccagct agcccagtca 194221 cagacacctt tgatcaaaag gtgtcttttt tcttttcgga aaaatcattc caacttctaa 194281 ctgttcagtc tgtataataa ttttaaaaat atgttaaggt agtttattca cgaattacca 194341 tctacaccct gccaaaaatt tgataaactt attttataaa aaaattgaaa ccttttgaaa 194401 cgaagctcgt atacatacag accggtgaag gcagaggtta gataaatatg gaaatgatga 194461 ttaaaaaaag aattaaacaa gtcaaaaaag gcgaccagga tgcatttgcg gacatcgtag 194521 atatttacaa agataaaatt tatcagcttt gctaccgtat gcttggcaat gtgcatgagg 194581 cggaggatat tgcacaggaa gctttcatca gagcgtacgt taatatcgac agttttgata 194641 ttaaccggaa attttcaact tggctttatc gaatcgcgac caatttgacc attgaccgca 194701 ttcgcaaaaa gaagccggat tattacctcg acgcagaggt ggctggtacg gaaggcttga 194761 ccatgtattc tcaaatcgtc gcagatggtg ttttgcctga agatgcagtt gtatcgctgg 194821 agctctcaaa cacgatacag cagaaaattt taaagcttcc tgacaaatac agaacagtca 194881 tcgtattaaa gtatattgac gaactctcat taattgaaat cggggagatt ctaaacattc 194941 ctgtggggac tgtgaaaacg cggattcaca gaggcagaga ggctcttaga aaacaattaa 195001 gggatcttta agtggggtga tgaaatgagc tgtcctgaac aaattgtgca gcttatgcat 195061 atgcatcttg atggagatat ccttccaaaa gatgaacacg tattaaatga acatctggag 195121 acatgcgaga aatgcagaaa gcatttttac gagatggaga aatccatagc gctcgtacgg 195181 agcacatcgc atgtcgaagc ccccgcggat tttaccgcta atgtcatggc aaaattgcct 195241 aaggagaaga aaagagcttc tgtaaaaaga tggttcagaa cccatcccgt tatcgcagct 195301 gctgcggtat tcatcatttt gatgggcggg ggttttttta acagctggca taatgaccac 195361 aatttcagcg tgtccaagca gccgaatctt gtggttcata accatactgt gaccgtgcca 195421 gaaggtgaga cggtcaaagg tgatgtcact gtcaaaaacg gcaagctgat tattaaaggc 195481 aaaatagacg gggatgtaac cgtcgtaaac ggcgaaaagt atatggcctc tgctggacaa 195541 gtcaccggtc agattgaaga aatcaatcag ttattcgact ggacatggta caagatgaag 195601 tctgcgggga aaagtgtact cgatgcattc aatccgaacg gagaagagta aagcgcgtta 195661 gccgctttgc tctttttttg cgggctgaga gggctggcac atttcacttg ctaaatcgaa 195721 atgtggtata atgggctcgc tatgtaaagt acatatgcgt aacacgtaaa acacaaaata 195781 cgaaatgact gaaatcttgg aggacgagga aatggctttt gaggatatcc cttttttgca 195841 gtacctcggc aatgccgttg atattctcct tgtttggtat gtgatatata aattgattat 195901 ggtgatacgc ggcacgaaag cggttcagct gttaaaagga attgtagtca tcgtgcttgt 195961 tcgtatggcc agccaatatt tgggcctcag cacacttcaa tggctgatgg accaagcgat 196021 aacatgggga tttttagcaa ttattattat ttttcagcct gagctgagaa gagcgcttga 196081 acagctaggc cgcggccgct ttttttcgag gagcggcacg cctgttgaag aagcgcagca 196141 gaaaacgatt gaggccatta caaaagcaat caattatatg gcgaaacgcc gtataggcgc 196201 cctgctgacc attgagcggg atactggaat gggcgattat attgagaccg gcataccact 196261 aaatgccaaa gtcagctctg agctgctgat caatattttt attccaaaca ccccgcttca 196321 tgacggtgcg gtaattatga aaaataatga aattgccgcg gccgcctgtt atctgccgct 196381 ttctgagagc ccgtttattt caaaagaact gggcacgcgg cacagagcag ctgtcggtat 196441 cagtgaagta acagacagtt tgacgattat tgtgtctgaa gagaccggcg gcgtcagtgt 196501 ggcaaagaac ggcgaccttc acagagagct tacagaagaa gcgctgaaag aaatgcttga 196561 agccgagttt aagaaaaaca ccagagacac ttcttctaac cgctggtatt ggaggggcaa 196621 gaaaaatgga taaattctta aacaaccgct gggctgtgaa aattattgct ctgcttttcg 196681 cgctcttgct ttatgtggcg gttaacagca accaagcacc gactccaaaa aaaccgggtg 196741 aatctttctt tccgacatca acaactgatg aagcaactct gactgatatt ccggttaaag 196801 cgtattatga tgatgaaaat tacgtcgtga cgggtgttcc gcaaacggtt aatgtcacga 196861 taaaaggctc gacaagcgcc gtgaaaaagg ctcggcagac caaaaacttt gaaatatatg 196921 ccgatatgga acatttgaaa accggcacac ataaggttga gcttaaggcc aaaaacgtgt 196981 cggatgggct gacaatctca attaatccgt ctgttacgac agtgaccatt caggaacgga 197041 cgaccaaaag ttttcccgta gaagtggagt actacaacaa aagcaagatg aaaaaaggct 197101 attctccgga gcagccgatt gtcagtccga aaaatgtgca gattaccgga tcgaaaaatg 197161 tgatcgataa tatttctctt gtaaaagctt cagtgaattt ggaaaacgca gatgaaacga 197221 ttgaaaagga agcgaaagtg actgtctatg ataaagacgg aaacgcgctt cctgtcgacg 197281 tggagccctc ggtcatcaag attaccgttc cggtgacaag cccgagtaaa aaagtgccct 197341 ttaaaattga acggacagga agccttcctg acggtgtcag catagcgaat attgaatcca 197401 gccccagtga ggtaacggtt tacggctcac aggatgtgtt ggattctctt gaatttattg 197461 acggcgtcag cctagattta agtaaaatta acaaggattc cgatatcgag gcagatattc 197521 cgcttcctga cggtgtcaaa aaaatctcac cgtcaaaggt gactttgcat atagaagtcg 197581 atagtgaagc ggatcagaag ttcgagaatg tccctatcaa gactgtaggg ctgagcagct 197641 cacaaaacat tgaatttctt gatcctgaat cacaagcgat agatgtaacg gctaaaggct 197701 ctcccacgaa tataaataaa ctgaaaaaat cagatattga attgtatgtg aatgtttcag 197761 atttagagga cggggagcat agcgtgaagc ttgaagtgaa cgggccacag aatgtaactt 197821 ggtccttggg gcggaaaaac gccaaaatca agctgacgtc taagaaaagc aatacatcaa 197881 cgaatgataa cagcagcaat acatcaggga accaggacac agataaacaa acaaatgatc 197941 aaaagaacaa tcagcaagaa gatacaaaga acactgataa aaacaacaac gatcaaaacc 198001 aagacggaaa taaagatcaa aaccaagatc aggatgagga tgaatccact gcgaattcac 198061 aatcctcatc ggaataaaaa aggagcgatt ataaaatggg caagtatttt ggaacagacg 198121 gtgtaagagg tgtcgccaat agtgagctta cacctgagct ggcctttaaa gtcggacgtt 198181 tcggcggtta tgtgctgaca aaagacaaac aacgtccaaa agtgctgata ggccgcgata 198241 cacgcatctc cggccatatg ctggagggag cccttgtcgc cggactttta tccattggcg 198301 cagaagtcat gcgcctgggt gtcatttcta caccaggtgt atcttatttg acaaaagcga 198361 tggatgcaga ggcgggcgtc atgatttccg cttctcataa cccagtgcag gataacggca 198421 tcaaattctt tgggggagat ggatttaagc tttctgatga acaggaggct gaaattgagc 198481 gcctgatgga cgaacctgag gataagctgc caagacctgt cggagcagac cttggacttg 198541 taaacgatta ttttgaaggc ggacaaaaat atctgcaatt cttaaaacag acagctgatg 198601 aagatttcac aggcattcat gtggcattgg actgtgccaa tggcgcaacg tcatccttgg 198661 cgacacacct gtttgctgat ttagatgcag atgtttctac aatggggact tccccgaacg 198721 gattaaacat taatgacggc gtcggttcga ctcatcccga agcgctcagc gcgtttgtca 198781 aagagaaaaa cgcggatctc ggtcttgcgt tcgacggtga cggcgaccgc ctgattgctg 198841 tcgatgaaaa aggaaatatt gtagacggcg accaaatcat gtacatatgc tcaaaacatc 198901 tgaaatcaga gggccgttta aaggatgata cagtggtttc aaccgtgatg agcaacctcg 198961 gcttctataa ggcgctcgaa aaagaaggca tcaaaagcgt gcagacagct gtcggcgacc 199021 gctacgtagt agaagcaatg aaaaaagacg gctacaacgt cggcggagag cagtcaggac 199081 atcttatttt ccttgattac aacacgacag gggacggatt attgtctgct attatgctga 199141 tgaacacttt aaaagcaaca ggcaagccgc tgtcagagct tgcagctgaa atgcagaagt 199201 tcccgcagct gttagtcaat gtgagagtga ctgataaata taaagttgaa gaaaatgaaa 199261 aagtaaaagc agttatttct gaagttgaaa aagaaatgaa cggcgacggc cggattttgg 199321 tgcgcccttc aggaactgaa ccgctcgtcc gtgtcatggc tgaagcgaag acgaaagagc 199381 tgtgcgatga gtatgtcaat cgcattgttg aagtcgtccg gtcagaaatg ggattagagt 199441 aacgaagtct attatcagag agtgaacaag acaagcgagg tttacataag ataattgtga 199501 gacatacggc aaagttgctt aaaaaacaat tgaccgttta tgccacatgt tgtaaaatca 199561 agcttgtctt gttcttattt tctcaatagg aaaagaagac gggattattg ctttacctat 199621 aattatagcg cccgaactaa gcgcccggaa aaaggcttag ttgacgagga tggaggttat 199681 cgaattttcg gcggatgcct cccggctgag tgtgcagatc acagccgtaa ggatttcttc 199741 aaaccaaggg ggtgactcct tgaacaaaga gaaatcacat gatcttccaa aaaacatgta 199801 ggaggggacg attgaaagtc cccttgaaat ttgactttct tcgtctcctt ttacaatctt 199861 aggaggaaga aaaatatgtg tggaatcgta ggttatatcg gtcagcttga tgcgaaggaa 199921 attttattaa aagggttaga gaagcttgag tatcgcggtt atgactctgc tggtattgct 199981 gttgccaacg aacagggaat ccatgtgttc aaagaaaaag gacgcattgc agatcttcgt 200041 gaagttgtgg atgccaatgt agaagcgaaa gccggaattg ggcatactcg ctgggcgaca 200101 cacggcgaac caagctatct gaacgctcac ccgcatcaaa gcgcactggg ccgctttaca 200161 cttgttcaca acggcgtgat cgagaactat gttcagctga agcaagagta tttgcaagat 200221 gtagagctca aaagtgacac cgatacagaa gtagtcgttc aagtaatcga gcaattcgtc 200281 aatggaggac ttgagacaga agaagcgttc cgcaaaacac ttacactgtt aaaaggctct 200341 tatgcaattg ctttattcga taacgacaac agagaaacga tttttgtagc gaaaaacaaa 200401 agccctctat tagtaggtct tggagataca ttcaacgtcg tagcatctga tgcgatggcg 200461 atgcttcaag taaccaacga atacgtagag ctgatggata aagaaatggt tatcgtcact 200521 gatgaccaag ttgtcatcaa aaaccttgat ggtgacgtga ttacacgtgc gtcttatatt 200581 gctgagcttg atgccagtga tatcgaaaaa ggcacgtacc ctcactacat gttgaaagaa 200641 acggatgagc agcctgttgt tatgcgcaaa atcatccaaa cgtatcaaga tgaaaacggc 200701 aagctgtctg tgcctggcga tatcgctgcc gctgtagcgg aagcggaccg catctatatc 200761 attggctgcg gaacaagcta ccatgcagga cttgtcggta aacaatatat tgaaatgtgg 200821 gcaaacgtgc cggttgaagt gcatgtagcg agtgaattct cctacaacat gccgcttctg 200881 tctaagaaac cgctcttcat tttcctttct caaagcggag aaacagcaga cagccgcgcg 200941 gtactcgttc aagtcaaagc gctcggacac aaagccctga caatcacaaa cgtacctgga 201001 tcaacgcttt ctcgtgaagc tgactataca ttgctgcttc atgcaggccc tgagatcgct 201061 gttgcgtcaa cgaaagcata cactgcacaa atcgcagttc tggcggttct tgcttctgtg 201121 gctgctgaca aaaatggcat caatatcgga tttgacctcg tcaaagaact cggtatcgct 201181 gcaaacgcaa tggaagctct atgcgaccag aaagacgaaa tggaaatgat cgctcgtgaa 201241 tacctgactg tatccagaaa tgctttcttc atcggacgcg gccttgacta cttcgtatgt 201301 gtcgaaggcg cactgaagct gaaagagatt tcttacatcc aggcagaagg ttttgccggc 201361 ggtgagctaa agcacggaac gattgccttg atcgaacaag gaacaccagt attcgcactg 201421 gcaactcaag agcatgtaaa cctaagcatc cgcggaaacg tcaaagaagt tgctgctcgc 201481 ggagcaaaca catgcatcat ctcactgaaa ggcctagacg atgcggatga cagattcgta 201541 ttgccggaag taaacccagc gcttgctccg ttggtatctg ttgttccatt gcagctgatc 201601 gcttactatg ctgcactgca tcgcggctgt gatgtggata aacctcgtaa ccttgcgaag 201661 agtgttactg tggagtaata attaattaac ccctttggat aagaaggtct tcacatgtgc 201721 tgctaggctc caaatgtaca cctttccgta agggcaaagt caaatgtgaa aaaaaactgt 201781 tccaaagtta atcagaaatt tattttcata ttgtatcctt cggtatcaag tgaaaggagc 201841 atcatatgaa aacattatgg aaagtcctca aaattgtttt tgtcagcttg gctgctttgg 201901 ttttgcttgt atccgtctcg gtatttattt atcaccattt ccagctaaat aaggaggcgg 201961 cactgctgaa aggtaaaggc acagtagtcg atgttgacgg taaaaagatg aatgtgtatc 202021 aagagggaag cgggaaggat acgtttgtgt ttatgtccgg ttcgggtatt gctgcgcctg 202081 cttatgaaat gaaggggctg tacagcaagt tttcaaaaga aaataagatt gctgttgtag 202141 atcgggcagg ttatggatac agtgaagtgt ctcacgatga cagagatatt gatacggtat 202201 tggaacagac gaggaaagcg cttatgaaaa gcggaaataa gcctccttat attttaatgc 202261 ctcattcgat atccgggatt gaagcgatgt attgggcaca gaaatatcct aaggaaatca 202321 aggccattat tgcgatggat attggattgc cccagcagta cgtcacgtat aaattgagcg 202381 gagttgaccg attgaaagtg agagggttcc acctgttaac ctcgattggt tttcatcggt 202441 ttataccttc cgctgtatat aatcctgagg tgattcgaca gtcgttttta actgatgaag 202501 aaaaagaaat ctataaagcc attaacttta agcaattttt taatgcagat atggagcatg 202561 agcttttaca gtcttaccaa aacggcagca aatctgtgaa tctgcctgcg ccaaaggaaa 202621 ctcccgtctt gattttagat gcagtctctg accaaaatag acattcaaag tatgctatac 202681 aaaaccgaaa agactatgaa gcgtttgcgg ctcaattcaa tactgccgat ataaaggaac 202741 tgaggggaac acacagtatt tatttatatc agcctgatca aatatataaa ctgtccatgg 202801 agtttatgag aaaggttcgc taggatgaag ggttatcgta ttttaatcgt tgaggacgat 202861 gtgatgattg gtgatttgct gcaaaagatt ttgcagcgcg agggatatcg tgtgatatgg 202921 aaaacagatg gagcggatgt gctttcggtg attcagaagg tggatttggt cattatggat 202981 gtgatgctgc cgggtgaaga cgggtatcaa atgtctgcaa aaatcaaaaa gctggggctg 203041 ggcattccgg ttatttttct ctcagcccgc aatgacatgg acagcaagct tcaaggtttg 203101 cagatcggcg aggattatat ggtaaagccc tttgatccga gagagctgct attaagaatg 203161 cggaatatgc ttgagcatca ttatgggacc tttacgcaaa tcaaacattt gtatattgat 203221 gcggtaacga aaaaagtgtt caatgaaagc ctgcatgatg aggtattatt tactgcgatt 203281 gagcggaaaa ttttctttta tttatatgaa aatagagaca gtatcctgac aaaggaacat 203341 ttctttgaat atctatggca gctcgaagat agaaacccga atattgtcaa tgtgcatatt 203401 aaaaaaatta gagctaaaat caatgatcaa gcgggtgaga tgattgaaaa tatatatgga 203461 gaagggtatc ggctgaatac cgttgtgaag aaatgaagct caagacaaaa tatcagttgt 203521 tattgtttac ggccgtcatt agtgttccga tgctattgct ggcggtcagt gttttgatgt 203581 cggtgattta tgacagcatg tttaaaccga tgaatcatgg tatgcccttt cacaggtcgt 203641 ttgcataccc ggcaatgatc gttgtatttt tgatatcact cttattgtta gcttttttat 203701 tttcaaagtc gattcattct ctgttgcata aaatcaatct attaaatcaa accattcggc 203761 atttggcgag tgatcaaagg gtgcccgata aaattgaagt gaagcgtgct gatgaaatcg 203821 gggaactgat caagtcggtc aatttgttaa ttgaacggac gacatatcgt gaactggagc 203881 tgagacagca ggaggaaatc aaaaaggagc ttttgcaaaa actgcggcat gacattaata 203941 cacctttaac ggctctcagg ctgcagttat tttatttgga agaccaatgt catggtcagg 204001 ctgtattcga atcattgtat cagcaaatcg aatatatctc ggaattaact aatgaattca 204061 atctatattc cgctgagacg ctggaaagct cttatattgt aaatgaagaa gtgcgtctaa 204121 acgagctatt agaaacagcg gtgaaaaagt gggattattt atacagtatg agtgggattg 204181 agctgcacta taagccggca gatcaagatg tgatatggat gagcaacacg ttatggatgg 204241 aaaggctgtt tgataatatt tttcaaaata cgttaaggca ttcaaaagct aaaaagatgg 204301 aagtcacgat tgaacatggc gatgttttta ttcgtgatga cggtattgga tttgatcgga 204361 atgagagcag tgagggactt gggttaaaga ttattgagga tacatgcagg ctgcttgcga 204421 ttacttatga gctgcataca aatgataacg gaacggggtt cttgttttca aaagagtgac 204481 cccgctgatg tttttctttc tcctataaaa tttatataat agggagaaag aaatggggtg 204541 aacatcatat gtttaaaaaa atcatcaaaa cgattaagta cctctcaagc agttctagtg 204601 accgatatcg cagacaccgg cattacagca gcagccggcg cagacattat cgcagctaca 204661 gcagcagttc gggcaaaaga agacactacg accgttatgg cggcagtcat cgttacaaac 204721 gccggagcta cagcagcagt taatccaaaa aaagttcttg ttccgctttt gggacaaggg 204781 tttttttatg tgaccgattg aatggcccgg tttagatcct cgcgaatgga agcggtgtgc 204841 tgatactctt cctcaatgcc caataatctt ttcagcagca aggttacttc ctttgtcagt 204901 gttaattcct ccagccaagt gccgtttttc ttcttttttc ctttatattg agagtacagc 204961 aagaataaca gcgtttctcc gagatcgaag aagtcatcct gttttcgtac ctttatttcc 205021 tccatttctt caggagtcaa ttgtttggca aggccgaaat cgatgaggca gagcctgcca 205081 tcattgatga tgatattagg cgttctgatg tcgctgtgga agataaggcg atcatgcagg 205141 tattctataa tctcaagcag ctgcgaaatc agttgtaacg ccataagctc tgtgaacggc 205201 tgttttcgaa aaaataataa ttcttctata ttctctccct caatgaactg catgacataa 205261 taagcctgtc cgtctatgat gaattcatct atgaagcccg gaatttgcgg gtggtgaatg 205321 tttttgagca gttttatttc ctgctggaat cggactttct ctttttcctt tttggctttt 205381 gtcggccgaa gctgttttaa gacataaggt gtttgagcta ggatatcggt gcacaaataa 205441 accaaaccgt agcctcccat accgaggcac tcttcgattt tgtattgatg atttaagata 205501 acgccgttct ttagagggcg gtcaaatagc agttttttta gaagttttaa tgccatgtct 205561 gcacttccct tggttgtact gactatagtt taccttctag acggagaata aaaaagagcc 205621 ggataaccgg ctcggtataa gttaaaactg ctttgtcacg tcgtattcat aatctatttt 205681 tgcttttacg ttgctcatcg tcgatctggc tgtcgctaat gtattatatt taaaactcca 205741 tacctttgcc acactgagtt gatccgacaa agagatatca taagaccctg aagtcgagct 205801 gtttacaagg gcacggctcc attcgttatt ttcgcttgtc atgatcagat ggcgtgtatt 205861 tccctggctt ggtgtttgag tggcggttgt ttgaactctg gttacaatgg catcacgcgg 205921 tatcccagat tggtttgtta aatcaacctt gatcacgctg gagtcagaac ctgaggggct 205981 aaggcttgta tttcctttat tttcagcaac gccgctgaat tggaacgttc cgctgcctga 206041 tttgattcgg tcttcaattg aaagcgtaaa gtacatgttt ccagtatagg tgcctcgtga 206101 cactttcaca tagaaggtat ccgtcgtgtt ttgggcgtct gcatttgcat aaataaaaga 206161 agaaaacgta ttagggttaa taacttctgt cccttgagaa acaggtattc tgttcttgtc 206221 ataaatttca attttcatcc ctgtatacgc gctctggtat gtactcctca tgtatacttt 206281 ttctccctta ttagccgtaa aagtgaaata ggcttcatct tgaccagctt ccagtattgt 206341 tgtatcgata tttttatatt tccaataacc gatcggcatt gcggtatcaa atgaattgtt 206401 tcctgtgata gcagtgactc cgacagctga tgccgaatac gtaaaggtag ataagacaga 206461 aagcataaca gcgaattgaa taagccattt tttcaccatg caaacaacct ccttttattt 206521 ccatcataca taataacgat ttaggtgtaa ataaatgttt tttgaggtta atatatacat 206581 tatattcgcc gataaaaaag aataagagag aatactcggg agggaattca atgcgtctga 206641 atcggcaatt tatccgcact cagctgattg cacagaacat attgagcaag aatgcgcctg 206701 ccaaacggga gaatgcgact gaaaatccag cggcagttct ggaaaaggca tatagcaggc 206761 ttaagtcaca atcttcaact gggggaatca atcagttcaa ttattctaaa accagcgtgt 206821 cgggaaacag cgggacgttc agcaaagtgt atcaatcagc gaatgatcga acagtgacag 206881 acacagggga agaaacagtg attcaatccc aaaaccccta tgaatctgag agtgatatca 206941 gaatcaaaat actagatgaa aaatacagca ggatgaatgc gattaataaa acaaagtctg 207001 atccattagg ctatattaag gataagtacc aaaattcaaa gtctccttat ttcagaagtg 207061 atctgtcagc tgcagaaaga caggccgctt acgataatga aacagaatgg ttattcaaag 207121 ggaaggcgca aaactataac cttcaggatg ctgtgtttcg gaatgtcaca tttcatgggg 207181 aagtggaagc tgagaatgaa aaggtgtatc agcggggaca ggttaaccag cagctgcaag 207241 tactgttgaa tcgaaaccat attcatattc cagaggggac agagctgacg tttacaatca 207301 caccgattga ctatcaggtg cgggtaagcg ggacagacga tcaggatctg atcaagcaaa 207361 ttgagcaagt gctgcaatct ggagacaaca gcaaagaact atttttacac atcatgaaaa 207421 gtcaaagcag tgattcagca caattttccg aagaggccta taaaaagtat caggcagctc 207481 gtgagatgta tgaagttaca ggctaccatt tgaaggattt agaagtgatt gatgggcggt 207541 acgtcacgcc tgagggacgt gacttaatgg atgtatataa ggaagagctt gaaaaagatc 207601 cagtgcagaa acaaacggct tcttatgcta tatcttacta tcgttcagag ctcagtaaaa 207661 tcgcggaagc cgggtataat gccattccgg atttcatcct atcaattgat tacagcaatg 207721 gatctctgag agatgtggga caaagcaaga gctatgggac cggagatacc gggtggcttg 207781 aagcattaaa gcgtcaaacg ggtgtgaatt attaggtaag ctgttcatgt aggacagctt 207841 attttttatg agaatctaag gggtgaatta atcccaatat tcaaataatt ttattatttt 207901 tatataaaag attttaaaag aagtgaacga ttcaaaactc tgaacaaagg tgtttacctg 207961 aaaaaaacaa ttgtattttc cagagaaatt tattatgatg aaataagtaa tttaggagat 208021 tatataacaa ttttaagttt gaattttctg attgttatca ctgattcatg tgaaggcaag 208081 caggtctgct gttttctcat ttatgagtat tttgttagga ggaggaagag gagtggcaaa 208141 taaagaatta aagaggggcc tgggcgcgcg ccatattcag atgatcgcct tgggcggtac 208201 aatcggtgtt ggcttgttta tgggttctgc cagcacgatt tcatggactg gcccatctgt 208261 ccttctggct tatgcaatat gcggaatttt tatctttttt attatgcgtg cgatgggtga 208321 aatgctgtat gtcgagccga gcacaggttc ttttgcgacg ttcggccatc aatatattca 208381 tccgatggca ggttatataa cagcatggag caactggttc cagtggatta tcgtcggcat 208441 gtcagaaatt atcgctgtcg gttcttatac gaagtattgg ttcccggatt tgcctgcttg 208501 gatacctggt atcgtggcaa tggtgattct tggtgcggcg aatttaattt ctgttaagtc 208561 gtttggggaa tttgagtttt ggtttgcgat gattaaaatc gtgacgatta tcttgatgat 208621 tattgcggga atcggaatta ttttcttcgg ttttggcaat ggcggagatg cgatcggttt 208681 gtcgaacctg tggtctcacg ggggcttctt tgcaggaggt ttctcaggtt tcttctttgc 208741 actgtctctt gtcattgcag cctatcaagg agttgagctg atcgggatta cagcgggtga 208801 agcgaaggac ccgcaaaaca cgctaagaaa tgcgattcaa agtattatct ggcgtatttt 208861 gattttctac attggcgcta tttttgtgat cgtgacggtg tatccttggg atgagctcaa 208921 ctcactcgga agtccgtttg tgtctacgtt ctcgaaaatt ggaattacgg cagcggccgg 208981 cattattaac tttgtcgtga ttactgcggc aatgtccggc tgtaacagcg gtattttcag 209041 cgcgggccgc atgctgtata cactgggtgt caatggacaa gcaccgaaat tctttaagaa 209101 gatttcacgc aatggtgtgc cgctgtatgg cacaattgcg gtgctgatcg gtttggctgt 209161 cggcgttgta ctgaactata tcgcgccgcc gaagatcttt gtctatgtat acagcgcaag 209221 cgtgctccca gggatgattc cttggtttat cattttgatc agccatatcg gattcagaaa 209281 agcgaagggt gctgcattag ataaacatcc attcaaaatg ccgtttgctc cttttacaaa 209341 ctatttgacg attgctttct tgctgatggt tctggttggc atgtggttta acgatgatac 209401 tcgtatctcc ctgattgtag gcgtgatttt cttagcgctt gtggtcatta gttattatgt 209461 gtttgggatt ggcaaacgca cgcaggccaa tttgacaaaa agcgaacaag cagctgaata 209521 acgataaaaa agagacattc acggatgtct ctttttttat ttttcgcgta tggattttcc 209581 ctattttagc aagctatagg gtaaagatag cagaaggaaa ggtgttcata aaatggatgt 209641 tacactcggt tatttgcgcg aatcactttc gaatcatcta gaaaatgaag tctgccagcg 209701 tatttgcaag aagatgctgg cgaagcgtta tgcaaatgaa gaggaatttg taaaagactt 209761 agatgataat gaaatgtctt ttttgaacca tgtattagaa aaagaaatta agtatgccca 209821 gaatgaacag gatcaaaaac gggccaagga attaaacgag gtgtatgaat tactgctttg 209881 agaaaggcgg gtaagaaatg ggagcaattg aacgaagcgg atatacattt cagccggagt 209941 ttagcgttgt ccgtcaaaac ggagccatcc atgtgtacca tcaaggagaa tttgtggaag 210001 aaatcgaatt tgaatttaac ggggaatatc ccgatcatga tttgattgaa gagcttgtga 210061 atcattattg ttttgagcat gagatttaga gccctgccgt gcagggctct tttatttagg 210121 atgtaatcag gccatacttt ttcaggatat ccacggtgat gtttttggct tttgtgccgg 210181 aatcatcgac attggtgaca aagacataag agccatgctc tgttttgatg aatccgacaa 210241 accatcctaa tcccatatca gtcaggcggg ttccggtttt cccgtagagc gtgtaatgat 210301 cgccttcctc ttgaatcatc atgcgcttga cgattttcat caccggcttg tcaaatggaa 210361 gctcctcttt agccagtttc tccaaaaaag tttcttgttc cagcggagat attgtgagcg 210421 agctttgcag ccaaaactgg tcgattcccc cgctgatatc ctcgttgccg taagatagag 210481 tatgaagcca tgttttcatt ctttcctcgc cgatatctct cgctaatgcc tgataatacc 210541 agattgcgga ttcgcgcatg gccgagccaa gcgtatggtc gcggttccat gattcgaatt 210601 cacgcttgac cccgtcccat cgtttaacat cgtattcatc tcttacagct ttgacctgca 210661 aaccgattaa agcgttcacg actttaaagg tggattgcgg agtttgtctt tgatttgccc 210721 gttttctgtt atagacaaat gtctgatcct tttgtaaatc gtgaagaatg aaggttccat 210781 ccgtatcctt gaattcatca tcgacattca ttttgctgac attcaagtgt ttttcatgag 210841 cagatgatgc tgcgtggacg gagaagccgc cgatccctgc aatactcagc acaagcacaa 210901 catatatcca ttttttcatt ttgttctccc cttcgttttg attaactacc ttttctctct 210961 ttcgtttgtt cttcctttaa aaaataatca aaaagcgctt aaatttggtt ttgcaaacaa 211021 atactgttac tgggtttata gtcggaagat aacgtgaaaa tagagggtaa aaaggaaggc 211081 agggtaagcg gatgaatgag cagattccac atgacaaaag tctcgataac agtctgacac 211141 tgctgaagga agggtattta tttattaaaa acagaacaga gcgctacaat tcagatctgt 211201 ttcaggcccg tttgttggga aaaaacttta tttgcatgac tggcgctgag gcggcgaagg 211261 tgttttatga tacggatcga ttccagcggc agaacgcttt gcctaagcgg gtgcagaaat 211321 cgctgtttgg tgttaatgcg attcagggaa tggatggcag cgcgcatatc catcggaaga 211381 tgctttttct gtcattgatg acaccgccgc atcaaaaacg tttggctgag ttgatgacag 211441 aggagtggaa agcagcagtc acaagatggg agaaggcaga tgaggttgtg ttatttgaag 211501 aagcaaaaga aatcctgtgc cgggtagcgt gctattgggc aggtgttccg ttgaaggaaa 211561 cggaagtcaa agagagagcg gatgacttca ttgacatggt cgacgcgttc ggtgctgtgg 211621 gaccgcggca ttggaaagga agaagagcaa ggccgcgtgc ggaagagtgg attgaagtca 211681 tgattgaaga tgctcgtgcc ggcttgctga aaacgacttc cggaacagcg ctgcatgaaa 211741 tggcttttca cacacaagaa gatggaagcc agctggattc ccgcatggca gccattgagc 211801 tgattaatgt actgcggcct attgtcgcca tttcttactt tctggtgttt tcagctttgg 211861 cgcttcatga gcatccgaag tataaggaat ggctgcggtc tggaaacagc cgggaaagag 211921 aaatgtttgt gcaggaggtc cgcagatatt atccgttcgg cccgttttta ggggcgcttg 211981 tcaaaaaaga ttttgtatgg aataactgtg agtttaagaa gggcacatcg gtgctgcttg 212041 atttatatgg aacgaaccac gaccctcgtc tatgggatca tcccgatgaa ttccggccgg 212101 aacgatttgc ggagcgggaa gaaaatctgt ttgatatgat tcctcaaggc ggggggcacg 212161 ccgagaaagg ccaccgctgt ccaggggaag gcattacaat tgaagtcatg aaagcgagcc 212221 tggatttcct cgtccatcag attgaatacg atgttccgga acaatcactg cattacagtc 212281 tcgccagaat gccatcattg cctgaaagcg gcttcgtaat gagcggaatc agacgaaaaa 212341 gttaaattaa aaagctctct tcctttatcg aagagagctt tttgattact tctttttttc 212401 atcgtagtat tggacgggat acatggagcc ttctgatacc attttgttgt cctcgatatc 212461 ttgcgggtcc gggtggccgg ctttatcaac tgggaacgtt tccatgtctg gctgttttgt 212521 tattttcatc ttcatgctgt gaatgaattc tcttgccttt tggcgatttg acgggtcttt 212581 taatagataa gaagtgatgc cgacagttga aacagcgaga cctgaaagta acagcttttg 212641 tttcatggtg atactccttt ctattttaag aatagtgttt cctgtatcat tcccgttttg 212701 gaaattgcta aacctgttgt gtttttatca ttggaattaa cagtaaattc catttaagaa 212761 gaaactagtg acttcattcc tgtattggaa ggtaatatac attgacttat tatagatttc 212821 agtcaaaatt cgataaatat tgacaaagta aagtaatcag aataataata taattagcaa 212881 gagaatgtca tcatacatga aaggtgttta cgatatgaat caattgcatc gaagaatggg 212941 aacgttttcc ctcatgatgg tcgggctcgg gtcgatgatc ggttcaggct ggctgttcgg 213001 ggcttggcgt gcggctcaaa tagcaggacc agctgctatt atttcatggg ttattggaat 213061 ggtcgtcatt ttatttattg ctctttctta tagtgaacta ggttctatgt tccctgaagc 213121 ggggggaatg gtcaaataca cgcaatattc acacggttcg tttatcggtt ttattgcggg 213181 ctgggccaac tggattgcga ttgtgtccgt cattccggtt gaagcggtgg cctccgttca 213241 atatatgagt tcttggcctt gggaatgggc gaaatggaca agcggtttgg tgaagaatgg 213301 aacgctgact ggggaaggac tagcgtttgc ctctgtattg cttctcattt attttctgct 213361 gaactactgg acagtcaatc tattttcgaa agcgaattca ttaattacga tttttaaaat 213421 tattattccg ggtcttacga ttggagcttt gctgtttgtc ggattccacg gagaaaactt 213481 tactggcggt caaagcattg cgccgaatgg ctgggcaagt gtgctgacgg cggttgccac 213541 ttccggtatc gtttttgcgt ttaatggttt ccaaagcccg attaatatgg cgggtgaagc 213601 aaaaaatccg gggaaatcaa tcccgattgc ggttgttggc tctctttttg ttgcgacagt 213661 gatttatgtc ctgctgcaga tcgccttcat tggagctgtg aatccttctg atattgctca 213721 cggctggagc catctgaatt ttaattctcc ttttgctgat ctggcgattg cgctgaatat 213781 taactggctt gttattgtgt tatatgcaga tgcatttgta tcaccgtctg gaacggggat 213841 tacgtatacg gcgacaacgt cccgaatgat ttacggaatg gaaaaaaaca aatacatgcc 213901 gagtatattc gggaagcttc atccgattta cggcgttccg cgacaagcaa tgttctttaa 213961 cttgattgtt tcgttcatct ttttgttcct gttcagagga tggggcgtat tagcggaaat 214021 tatttctgtt gctacgttaa tttcttatat caccggcccg atcacagtga tgacattgag 214081 acggacgggg aaagacctgt acaggcctct tcgtttaaaa ggcttaaatg tgattgctcc 214141 gcttggattt atctttgcgt cactggtgct gtattgggcg cgctggccgt taacaggaca 214201 ggttctgttt attatcctga tcggtcttcc gatttatttc tattatcagg cgaaggcgaa 214261 atggaaaggg tttggccgga actttaaagc cggcgtctgg atggtgtttt atctgctggc 214321 catgatggtt atttcttatt tgggcagtga taaattcggc ggcctgaatg tcattcatta 214381 tggctgggat atggttctga ttgcgatggt atcccttgta ttctatgtgt gggcgctgaa 214441 gagcggctac cagacagaat acttaaagga tgcgaaagag ataaattctc agctgcttaa 214501 tggacagtca gaagctgctg ccggaaaaga ataaaatata gaagaaaacc ttgcgatagt 214561 tgtcgcaagg ttttttgctt ttaataaccc ttttttactt tgtggaaaag atcaggatag 214621 ttggtgaaca ctcctgttac gccccaatca agcaggcgat gcatatcagc ttcattattg 214681 actgtgtaag gatgaagcag gaggccgtgg ctgcggatca tacggacgtt ttcttgattt 214741 aaagctttat aatccgggcc cgcaccgaca gcgtatgttt tgatttcttc cagggcagca 214801 tctgtcattg acgccatttg tttggcttcc agcaattgaa cggtcggcag gtttggctgt 214861 aattgatgga cttttaccag gctttctttg ctgaacgatt gaatgatcac ctggcctggc 214921 ttagaatgct ttcccagtaa tttatgtttc tgcaaagaag cgatcagttt ttcttccata 214981 cctgggtagg tgtcaggcga ttttgtttca atgtagtagt tcgcgtgctt tccgaaacgg 215041 tctaatacct cttctaatgt aggaacttta aggccgacgt actgcggctt tgctttttcc 215101 ggataggctt cattaaacca agaaccggcg tcaagcttct taatgtctgc gagcgtatgg 215161 tctttcaccc aacccattcc gtttgtggtg cggtccagtt tttcgtcatg catgacaatc 215221 aattttccgt cttttgtcat ttgcagatcc aattcaataa aatcagcttt cattttctga 215281 gcggtttcgt aagacagaat cgtgtgctca ggcacatatc cagaagcccc tctgtgcgcg 215341 acggtcagga tacggtcagg tgacagcagg tttccttttg acgctgccga cactggcgtt 215401 accataaatg agagtaagcc cagcgacaga acaaacaagg ccagtattct attttttctc 215461 atgatttctc ctccttatag ataagcacta cctgtctttc ataataaaaa acggatgtaa 215521 acggcgtgtt ggaaaactat taatctttta tgtgtctttc ttaaacatgc tctgcccgtt 215581 ttcctgtatt ccacgtcaaa gccaagaaga cgatggcaag aatgcaggat gagatcagca 215641 tgataaagcc gccgttccag ttaaaacggt ccacgacaaa gcccataatg gcgtttgcga 215701 aggcggatcc gccgatgtat ccgaaaaatc cggtcaaacc ggctgcagtt ccggctgctt 215761 ttttcggtgc taggtcaatt gcttgaaggc cgatcagcat aacaggtccg tagattaaga 215821 agccaatgct gatcagggcg atattgtcca cgagcggatt gccggccgga ttcagccagt 215881 acaccaatac ggcaatgaaa acacccgcca taaacaaaac gcctgccggt gcccggcggc 215941 ttttgaagaa tcggtcactg atccagccgc acaagatcgt tcccggtatg cctgcgtatt 216001 cgtaaagaaa atacgaccag cgtgagtctt caggagaaaa gcctttggct tctgttaagt 216061 aagtaggcgc ccagtcaacc acgccgtatc gcacgaaata aacaaataca ttggcaaaag 216121 cgatgtacca aagaaatttg ttgttcagca catattgaaa aagaatttct tttgttgtta 216181 attctttttc ctgattttta aaagcgtgtt ttggatagtc attccgatac tcttcaattg 216241 gcgggagtcc gcaggattga ggcgtatcac gaaccaataa aacaattaaa aatgaaatga 216301 taatggcgat gatggcaggg aagaaaaaca cgcttttcca agtgacgaac atcgcgatcc 216361 caagagtgac aagcggagca agaataccgc cgcctatgtt atgggcgaca ttccagatcg 216421 acatttttgt gccgcgttca cttatggaga accaatgggc catcgtcctg ccgcatggcg 216481 gccagcccat tccttgaaac catccgttga taaacataaa aataaacatg atggtgacgc 216541 tcgaagtcac ccaaggcatt gaaacgaata gaatattaac gattgctgat aaaaataggc 216601 ctgtcgccag aaaatatctc ggattacagc ggtcagacac cattcccatg atgaatttgc 216661 tgaagccgta cgcaatggac acagcggcca gcaccaaacc cagttctgtt ttcgaaaatc 216721 cctgttcctg cagataagga atggcaaagg caaagttttt ccgcagcagg tagtagcctg 216781 cgtagccaat gaaaatacca atgaatactt gcagtctgag ccgtttgtat gccgcatcca 216841 tctttgaatc atccagtctc tcaatatgag gagccggttt aaatatatta agcattaata 216901 attatccccc tttgctgttt gtgctggatg tgtggcgtgc ctcctttccc gaaaaacaaa 216961 aagagccaga aaacacccct tgtcaaaagg ggttggattc ctggctctcc tcatctccat 217021 ccaagctatt aacttatcat gatagcgctt tcttaaatta tcatagtccg gagcgaatgt 217081 aaacgggtaa ttttcaaatt gggccttagg gaagtgaata ttatcctttt actaaatgca 217141 attatatttt tttactagta acataaaaat ctggagggag gctgtttaaa gatggatgaa 217201 ttagatatcg cattctttat tttaccgtta ggaattatgc tgctatcgat tgtcgggacc 217261 tgtatttgta aaaacccgta tctgatgcca atgcttagtt tggtgatttc tcttgtgctc 217321 acctttacca tttttaatca atcatttttg ggatgggctg ttgtctatag cttggtttct 217381 ctggctttat cctatatcac attgattgtg gtaaggaaaa ggaaggaatc aggaaattaa 217441 aaagacctca ctttctaaca tatcgttgac taaagcaact atatgtgatt ataattgctt 217501 tagtcaacga tattagaaag tgggaattga tttgaaaaca agagaatcat ctgtcgggtt 217561 aaaattcaga aagttcaatc gattttatac aaacgtcctt ggtttcctta atgagcacat 217621 ttacgacagc ccgttttcct taacagaaac acggatttta tttgagattt ataatacgcc 217681 taattgtacg gcaaaagctc ttcaggataa gctggggctt gaccggggat atgtcagcag 217741 gattgtgaag cagtttgaaa aagaagattt gatttataaa cagaggagca aagatgacgc 217801 ccgccaccat tacatttttg tcacagaaac aggaaaaacg atttataaaa agctggagga 217861 gaaagccaac gaacaagtag aactgatgct gaaggtaatc aaccaaaagg agcagcacaa 217921 gcttgccgag gcgatggcag agattgaagc gatcctttca cagtcgcttt ctgccagagc 217981 atcagagata tcgattagag attattttct ttcggaggat cttcaactcc ttattgagaa 218041 acaaagacaa ttttacgcgg aggctcacgg ttgggatgac acgtttttag cttatcttca 218101 ggagacattt gacgctgaca tcgaaaaaat atggattgcg gaaagcggcg ggaaatttgc 218161 cggctctgtc gggttggtca agcacgatga aaagacagtc cagctcagat ggtttctggt 218221 tgatgcggat tttcggggca gggggcttgg cacgcaattg ctggagcatc tggttgcata 218281 ctgccaagac atgaagtttg accgcatttt cctttggacg gtgagcacga tggctgaggc 218341 tcgtccgctc tataaaaaat ttggattcag gataagtgaa gtaaaacaag aagcgccatt 218401 atggggacag cagctgacag aagaacggtg ggatttggag ctgtcatgaa aagactgcat 218461 tatgcgtgga tcatcgtctc cgtcaccttt ttgatcttat tggcggttca gggggtgcgg 218521 ctgtcgtttg gtgcgtttgt ggagccgtgg gaacggcagt tttcaatcga tagaagcacc 218581 atctcgctga tttcgacggt gagttttatt gtttatggca tatcacagcc tgtgatcggt 218641 cggcttgtgg acaaatgggg tgcccgggct gttttggcat ggagtgcgtt actgacagga 218701 gtcagcattt tcttaacata ccttgtgact tcgccttggc agctgttttt gctttacggg 218761 ctgggtgtct cgcttggagt gggcggagca tcgaatgtgg cggcaagtgt attggtcgtc 218821 aattggttca gcaaaaagcg gggactagcc tttgggatca tggaagcagg ctttggcgcg 218881 gggcaaatgc ttctcgttcc cggctcactc atgttgatcc attggtttag ctggaagctg 218941 acggttgtgg tgttgggact gctgttaatc gtgattgtct ttccggctgc gctgctgatg 219001 ctgcggaaca atccttcaga aaagaataca gagccgatag gcggactggc tgcatcagaa 219061 aaagaaacag cacccaaaac aacagctctt tcagtggccg ggatgtttcg tatgaggcaa 219121 ttctggttct tgatttttcc gtttttgatc tgtggattta cgaccgtggg gctgatggat 219181 acccatttga ttccgttttc tcatgatcat ggcttttcaa cgacagtcac gagtgctgct 219241 gtcagtctgc tagcaggctt taatattgct gggatcttgc tgtccggaat tgtagcggac 219301 cggtggagca gccggaaaat cctgtgcatt ttatatgcgg tgcgggcgct gtcgatcgtg 219361 attcttattt acagccacga gccctacttg cttttagcct ttgcgattct gtttggatta 219421 gtggactttg caacggtagc accgactcaa atgctcgcca cccagtactt tcaaaactac 219481 tcgatcggcc tcatgattgg ctggctgtca ctcgcccatc agatcggatc ggcactaggt 219541 gcgtatgtgc ccggcgtcat ctacacggta acgggtgagt atacactggc tttttatttg 219601 tcgattggaa tgctcgtgct tgcgagcgta atgaatgtga tgctgaggga gccagctgcg 219661 gttacgcgtg acagtgcggc tgtggtagac aagtgatgag gacaaaggga aagcatctct 219721 gatttcgaga ttattcagag atgctttttt tgtatttttg ttctaatacg aagtcgatca 219781 taccgactat gcgggcgttt tcggattttt gtttgaagcg ttcagaaatt tgaacttttc 219841 ttgaaaatgg ggaaacaata aaaacccaaa aaaggccgat caaggcaaaa aacatttgta 219901 cagctaattc tattaattca ttaaaacgag tgctgaaaaa atagaagtat aacgttatta 219961 atgtcacagt acatacgatt ttggcaagtg tgtttgaatg taagcaatgg ttcactaaag 220021 aataccttta attgattcag catgattgaa tcatatttgt ttaggaaaat aagaagttct 220081 ttatcatctt ttttatgttc taaaataaag ttgctgtttc tgtttcttta tatgtatggt 220141 ggtctacatt caatatatac atctcttaaa gtataaaaat tgagtatttc ttagtaagga 220201 tgaaacaaaa ttacatgatt tttttgttat atctttcagt tagaataaaa tctataactc 220261 ctctcattcg caaatattcg gctctctgtg caaagtgcag aacagtatgt aattgtcctt 220321 ttctagatat atttaaaagc tttatcaaat caataaggat tttcaagaaa ataattaata 220381 atagaaagat aaaaatgtgt ggtatgtcaa tgtaattgat ttgtcctgaa aataaagaag 220441 ttgcatagac aacaataata cttccgcaaa acatcaaact catataatgt ggaagggaaa 220501 atggacgagt tgaaaaatat gcttttaatt ggcttagcat agcattatct cttgtatcta 220561 agtagcccaa aagctcttta tcatttttac taattgtaag aacatgattc aatacagcac 220621 taaaattcat tgaatcttca ttatcagagg cagtatgttt attagcctgt atgttttgtt 220681 gatccatttt atatttttta taaagtattg tattaattaa cttgtttttc tcatagaatt 220741 cagatcgttg attaagggat gcttttcctt tgtttttatt tccttttttt atgattttag 220801 tataagtcat aaaaatacaa atgactgtaa aaatagaaaa cactgcaggt gaaatatctg 220861 aaagaatagt attggtgaag acttcttttg cttggatgaa aaggaaagaa gctaaagtca 220921 tagatataaa catgcataaa actgctactt tcacaagaaa ctgaagcgga agagaaggtt 220981 ccgaataata gtgcttcaac tggttgagtg tcagagaatc ttggcgaaaa agataatcta 221041 ttatctcctg ctgattttgc atctgattga tatcatgagc gatgtttttt gttttttcaa 221101 aaactatttg atcatttttc atttttgata aacctccaaa agacgataga taaactaaaa 221161 aaactgcatg agcatatttt aacttatgtt catgcagttt tgtattaaag ttagctagta 221221 taataagcaa aaatggccag taacatagca gataatgcgg tagcgacttt gactccttta 221281 ttgttcgtta aatcactgcc catattccca attagtaaaa gtgcagcaac acctacaaca 221341 gggaataaat attgatcata agacggccaa tctaacgcta attcactctc gggagacgta 221401 actggtactc ccttgtacgt ctttatttta aacgtaatcg tagtcgttag tccagttgtg 221461 acattgtcac cgactggaat atcaggtgta tagattttaa tttgaatgtt taaagattca 221521 gctgttggat ttacataaac ctccaaataa ccgttgcgta ctgataagct cagactattt 221581 aaaaggtttt gataagagtc gatttgtgac gcagtgagag acgtttgagt gtcgcccaat 221641 aaacccgtga tataggcacc tggtttacca tttgtaatgg taattgtgtt tggtgaacct 221701 tcacttggta tggttgccag aagtgaagtt gatagaataa tatccaactc aggtgatgtg 221761 aaaatggttt ctgtcgtatc aaattcaaac atcgcgtttg ccagacttgt tagattttct 221821 aaagctggaa tggtagataa aatgtctgtc agtgtacgca gtcttgcatc atataccgga 221881 tcagacggcg gatttacatt gcttgcacct gagtctcttc ctgaataccc gtctttatca 221941 atcccgatgc ttccagagcc gcttccgatg gttccttcat aaaattgatc aaaggcccag 222001 ttgtttggca tcggatagcc gagattgccg ctaaatcctg ttgacatatt tgccacaaaa 222061 ctatactttg tcagtcctgc ttcagatgta cggatacaaa tgtttcttgg tccgtaaacc 222121 cctatttcat acttaggtgc ggttgaaaat gtctgcattt ttgtaaatgc tgacttaatc 222181 tcttggaaat aaggaatgat tttatcggtc acttcataat cgtatgcatc aaaatcgaca 222241 gcgaaataaa tggtcgtgcc tgacggaaaa cctaatcttc tagcagcaga agcggcacta 222301 tatgcatctc ttgtgccttg gtctttgaca aaataagaag attcatagcc gccgtcttga 222361 taaattggga aaaccttcaa tccggcatca agaataactg caagctcttt agatgtcagg 222421 gctttagatg tgaggccgct gcttgtccgc acatttccgg tcaaatatct gccaaccgtt 222481 ttataaccgt tattccgcag tgtttgagct ttttctgcgg ttataattgt agcagtgtca 222541 caagcagaag cggtgcgagt tgtgtctcct gagcttgata ataaagcttt aatggttggc 222601 atatctgcat aacctgtttg cggcaggcac atgaactctt gaaatgcttt aacagctgaa 222661 acaacaccca caccatattt gccgtcaaac tcaccaggat cgaacgattt tccgttacaa 222721 tagagggcgt actgaacaat taagacaaat cctgttcttg aatcgccggg agttaaagta 222781 gggcacaaac ttgtggtgcc gtttccgaaa aatccattgg caacacttgt gctcatgcct 222841 tcttcttttt gcagggcata aataagagct ttatttgtat cgcggccata cagtccgtca 222901 caaggcatta acccgatata gtcattgtag tctcgattta agttttgttg aatctggcga 222961 attcttgaat cacccccaga caccagctta aaagcgctca tgtctaataa ggctttcata 223021 attaacgtgg tgacaatccc atcctgtgtt gtcagtccgg cagctttttg aaattctttt 223081 accgcatttt ctgttttttc gtaaaagacg cctgtaaaac cgccgggatt aaagccttta 223141 caccataaag ccccttgtaa aataaaattc atgttgcttg gttttgaatc tggagcttgg 223201 cgtttaagag gcttaaataa gcgctgtgtt gtcggcccga agttatcggc tggctctgag 223261 atacccaatt caatttgaag cgcccgagtc agaccgtaga tcgtatccca cccagttttc 223321 ccgctttctt caactgggtt atacccatgt ttgccgctgt acgtatcgtt cagccattgc 223381 tgtgtgatta agaccatttc atcaaccatt tcgattcctc ctttgttaga ttgcgttcat 223441 ttataggtgg caaacgtagg acaaaataaa aaaatggatg ccgttaagca tccattttac 223501 atccgttctc caacagcttc gctttcggtt tcagctctga aatgtagagg cctaaaagtg 223561 taagcgcgcc tcctagaaga gcgatccatg tcatgttttc gtgcagaatc aggacagaag 223621 cggcgatcgt gataaccggg accatgtaaa tatacgcact ggatttgacg gctccgagca 223681 ctccaactga ataattccaa gtggcgaagc acagggcaga agcgccaatc cctaagaaaa 223741 gcatgttgag tatatttgaa gcagatgaaa atcggcttag gtcaaaatgg aagtcgaaca 223801 aaaataaagc gggaaccata aacaataaac catacaaaaa tactctctgt gtcagctcga 223861 tgatgtggta ttcgtaggcg cttaattttt tcatgaatat cgagtatccg ccaaacacga 223921 gagcagcccc ggctgccatg atgtctccga gcggatttag acgcagtacc acattgccgt 223981 taaacgtaat caataaaagc ccgatcagtg ccgagataaa tccaatcaaa aaagtcagac 224041 gcaatttttc gccttcgagc agaaaatggg ccaaaaccgc agtgatcatc ggtataatgg 224101 acacgatcat gccgacattg gaggcgtatg tataggtgag agctatattt tctaatagaa 224161 agtataaggt tacgccaaat aaaccagctc cggcaaacaa cagctcctgc cgccaatttc 224221 tgaacggaat catgttggga cggacgagga taagagcgat aaagcccatc aaaaaccgat 224281 aaaataatat ttccattgga gagaagtcag ccagcagaac ttttgtcgaa ataaaggtcg 224341 tcccccaaat cagaatggtc acaatggctg cgatatgccc cgaagtttct ctttgtatgt 224401 tcatctgtga agctcctttt caaaaatctt catgtattgc ttcggcgtca gccccacctg 224461 ccgtttaaaa aacttcgtca tatgactctg atcgctgaat cctgtctgaa atgccgcatc 224521 aatcggcctt accccttgtt caaggagttt tttggcttga ttaatccgga ttgtttccat 224581 gtagctatta ggggtaatgc ctttttgttt tgtaaatgaa cgcaataaat gatacttgct 224641 ccagcctgtt aattcactca aatcattgag tgtaacattt tcggcataat gctcttctaa 224701 aaattcacaa accattttga cttcgtctga tggttctgga acgctgctaa ggaacgtgac 224761 atctgaataa tggcggatca gctcctctaa tagatgaaga aacagctcct ccttacgcaa 224821 agcttgtttt tcctcggata tcaaaatatg caattcctgc aggctggctg tcagctcatg 224881 gcggaataac acatgctggg agaaataagg gagatgcccg gagccagtaa tctctttcac 224941 cgccttctcc atgatatccg gcatgacatt gatacaccga taatcaagcg tccggccgtc 225001 aatctgttca cagctatgcg tgtcacgggg gttaaagagg agaagatcac ctggattgat 225061 gatatattct tgatcctgac aggccagata ccgttgccct ttttcaataa atccaatcac 225121 ataataatcg tgaaagtggt tcgggaactt ctgcataatt cccttgaagc ggtaggcttc 225181 tatatgaagg tgtgggtcaa gctgcagtgt gcgggtttcg ttttgcatgg gatgcctcct 225241 gtcggtgtgg tggtcttgga ttaagtgtag catgattttg ggggatttct tgtatgatgt 225301 tgctgtttag gaatagagaa agcagaccgt tatttgtctg ctttcgttta agaatttaaa 225361 agattttaac cctcaataat aattttatct tttttaataa aaatttattt ttcaaatatt 225421 tcagttataa tggtttggaa cagataggag gggcaaagat gtatcaatca aagaaggttt 225481 tattgttagg ttcaggtgaa ttaggtaaag aggtagtgat tgaagcccag cgtcttgggg 225541 tacagacggt ggcagttgac agttacgagc atgctccggc gatgcaggtc gcgcataaca 225601 gttatgtcgt tgatatgctg gacccagagc agatcagaac catcattgag aaagaaaatc 225661 cggatttgat tgtgcctgag gttgaggcga ttgcgacgga tgaattgctg aagcttgaag 225721 aggaaggatt tcacgttatc ccgaatgccc gtgcggccaa gctgacgatg gatcgggaag 225781 gcatcagacg acttgcggcg gaaacgcttg gacttgcgac agctggctat gaatttgcga 225841 atacatatga tgaatttata caagcggcag ctcagatcgg ttttccttgt gtcgttaaac 225901 cattgatgag ttcttctgga aaaggccaaa gtgtgtgccg ctctgaagcg gatttagaga 225961 gctgctggga gacggcgatg gaaggcggac gggtgaaaaa cggccgcgtg atcgttgagg 226021 agtttatccc tttcgaatca gaaatcacac tcttaaccgt acgtgcggtt aacggtacgg 226081 cattttgtga gccgatcggt catgtgcaaa aggacgggga ttatatcgaa tcgtggcagc 226141 cgcatgatat gacagagcag caaatagaag aagcgaagca tattgcgaaa acgatcacgg 226201 atgagcttgg cggatacggc ctgtttggtg ttgagctgtt ccttgcgaaa gatagggtat 226261 atttcagtga ggtatctcct cgtccgcatg atacgggtct tgtcacgctg gtgacgcaaa 226321 atttgtcaga atttgcgctg catgtccggg cgattctcgg ctttccgatt acagaaatca 226381 cacagctttc tcctggcgcc agcaggcccc tcaaagcgcc ggaagaatta gcggattaca 226441 ctgttgaagg attggaaaac gcactggcag tcccaaagac tcaagtgcgc gtctttggaa 226501 agccgataac aaaagccgga cgtcgtatgg cagttgcgct ttctgctgct gattcagttg 226561 aaacggcaag agagaatgca aagaaagcgt tggaccagct aattttaaaa tagagtttga 226621 acaggtcttg tcagatacaa gattcaatgc agtttgccgc ggttgaaagt ggtctgcgct 226681 tttaccaggc atatgatcaa agcctttctt tgtggccgat tgagtcggaa gcattctatg 226741 tttctactcg ttttggaaaa acacatatca ttgcaagtgg gccaaaggac gcaccttcgc 226801 tcattttgct tcacggaggc cttttcagct ctgcgatgtg gtatccgaat atcgcagcgt 226861 ggagcagtca atttcgtaca tatgcggtcg atataatagg agacaaaaat aaaagtatac 226921 catcagcagc catggaaacg agagctgatt ttgcagaatg gatgaaagat gtctttgatt 226981 ctcttggact tgagacggca catctggccg gcctttcgct tggcgggtcc catatcgtga 227041 atttcttact ccgcgcgcct gaaagagtag agcgggcggt tgttatcagt cccgctgaag 227101 cgtttatttc atttcatccg gatgtctata aatacgctgc agagcttaca ggggcaagag 227161 gagctgaatc atatatcaag tggatcacag gcgacagtta tgatctgcat cctttactgc 227221 aaagacaaat tgtggcgggc gtggaatggc aggatgagca aaggagcctg aagccgacag 227281 aaaacggctt tccgtacgtg ttcacagacc aggaattgaa atcaatacaa gtcccggtac 227341 ttctgatgtt cggtgagcac gaggctatgt accatcagca aatggccttt gagcgggctt 227401 cggtattggt gccgggaatt caggctgaaa tcgtaaagaa cgccggacat ctgttatctc 227461 tggagcagcc agagtacgtc aatcaacgcg tcttgtcctt tttatgcggg gggataaaat 227521 agtaaggaac atgaaaagat tggcattcat ttttcaaaag gtaacaaatg ttgtataata 227581 atagaatttg aatgctgctt tttttgggag cattctatgt tatcatgctt attggagaaa 227641 aatttttcct gtaacgctat tcgatcacta tcgtcaaata atatagatgg ttttacaatt 227701 ggaggtttgg ttacactgtg aattacatcc cctgtatgat tacgatagga aacttcattt 227761 gcggattgct ggcgattcat tccttgctat atcacaacat tcattcagca gtgcttttta 227821 tttttacagg catgttcctt gatttctttg acgggatggc tgctcgtaag ctgaatgccg 227881 tttctgatat ggggagagaa ctggattcgt ttgccgatct ggttacgttt ggggtggctc 227941 cttctatgct tgcttacagt gtcgcgttgt ataccctgcc atttatcggg atcttatgcg 228001 cattgacgta cagcatttgc ggaatgcttc gcctctctaa atttaacatt gaacaaagca 228061 agctcccgac gtttatcggt atgccgattc cgtttgcggg catgtgtctc gttattctaa 228121 gcttcaccta taacccgatc cttctggcaa tcggcacttg cggactctca tatttgatgg 228181 tgagtaaaat aaaattccct cattttaaaa aacatgcggc agaaaacctg gagtctggga 228241 gatggaatta gttcagcagc tcatagcgga ttacggttat ctcgctattt ttttgatgct 228301 ggtattagga attgtaggat tgccgattcc agatgaagtg atgatgaccg ttgttggcta 228361 tttcacgcat accgatgtat tgaattatga gctttcgata ttgattagtt ttgtcggggc 228421 tttgttaggt atgctgatca gctacatgat tggcagaaaa gccggacgcc cgtttatcga 228481 caagtacggc aagtgggtcg gcttaaaaga aaaaagaatg atgaaagtgg aaaaatggat 228541 gaagaaatac ggtccatatt ctcttatttt aggttatttt attcccggcg tcagacatgt 228601 gacgtgctac ttttcgggga tcggcaaaat ggatctgaaa acgtatgttg cgtttgctgc 228661 aatcggcgcc tttttatggt gctttgtttt tattacaatc ggaagggtta tagggattat 228721 tcatgtttaa tacggctgta aagattctgt atcgatcatt gatagagctg acgaatcatc 228781 gtctgtcatc ctatctgatt aaaggatttt gcgagtcgaa aatcagcaaa ccggtcattc 228841 cgcttttctc aaaacatttt cggctgaatt gggatgatgt ggacggtacg gctgctgatt 228901 acggatcgct gtccgaattg ttcattcgac aaataaatct ggagcggcgc cctgtgtcaa 228961 aagaggcgca tgcggtggtc agccctgttg acggtgtggt tcagacggta ggaatcatca 229021 acccgaatca aacctttacg gtgaagggaa aagattactc attcgctgag ctgaccggct 229081 gtaaaagcgc agaccatcaa tacaacggcg gatatttcgt cgtgctgtat ttaagcccga 229141 ggcattatca ccgtttccat tctccgatca gctgcaggta tcaaaagctg gccgagctcg 229201 gaaatcgctc atacccggta aatcaactag gcttaaaata cgggaaagat gtgctgtcga 229261 aaaattatcg gtttgtgtac gagctgaata gcggcagccg aaatgtcctg atgattcctg 229321 tcggcgcgat gaatattaat tctatcgtgc agacgaatac ccgtactgaa ttggagatcg 229381 gcgaggagct gggatacttt tcatttggct caaccgtcat tttggttttt gaaaaagacg 229441 cgttccagcc gtccgcccat ttagcagaag gccaagaagt ccaagtcgga gaactgatag 229501 gttacgaaga ataaaaagag gagcttgcat aaacgcagcg cctctttttt tgaagaaagg 229561 tgagattcat ggagaaacaa atcatcagct ggattacaga ttatcagaac accggagatg 229621 aagccgtcct gcggcaagtg cgagaagtgt gctggccgat cgttgaagcg gttttgcaag 229681 agaaagtaat ggatgatgaa caagcgaaca atttgcgcga aaaaggaatc gagcggtttc 229741 cattcatcat cagcaaatac caagcggatg tgcagcttcc ggttgagaca tttttacaaa 229801 atacgtatcg gttttacttt catcaggtga tgagagaatc cagctaaagc ttctttcaac 229861 agagaagctt ttttttgttg gcaggaaaag gaaacttttt ctatatctat ctcgtaatga 229921 ctagagaacc tagcagaaaa ggagagatag aattgaaacg aatgatagtg agaatgaccc 229981 tgccgctgct gatcgtttgt ctggcgtttt cttctttttc agcctcagcc cgtgctgctt 230041 ctgaagaaaa atattgggat cactggattg aacgacatgc acagcctctg gatgcttcca 230101 atgcttcaaa caaagacctt cgatttctaa aaaaggtgct gaagggaaaa cgaatcgttc 230161 agttaggaga aaccacacac ggtgctggcg aaatcaatgc cacaaaggtc agaatgatca 230221 aatacctcca cgaagagctg ggatacgatg tattggcctt tgaatccggc tttcctgata 230281 caaatgcatc ctaccttaat atggaccaat taacccctaa aagcacgatg aaaaactcca 230341 tttacgctgt atggcacaca gaagatgtcg tcgaattgtt tgattacatg aaagagcaaa 230401 aagagaaagg cgatccgctg atccttaccg gttttgatat tcaaagcatg aagaattcat 230461 tcaatgtagc tgcgactcaa tgggtaaaag cggtggaccc tgagaaagca gagttgctct 230521 cccaatcaga aaatgatttt tcaacattag tgacagacag caatacgttt gatgaatttt 230581 cgcaaaagaa ggaaaagctt gtgaaaaact atcagaagct gatcaagttc actaaaacac 230641 atgcttcaga gctaaaagaa aaccttccaa aagagccgaa agcttatgag atgtttatgc 230701 attctcttca gctgagaatt gacgtaatgg aaacatatat gctggaagaa atgaaagaaa 230761 aactagagga gtatccggag aatattgagg atttttcatt ctttatgaga gaccgcatga 230821 tggctgaaca atttcagtgg gtagccgaca ccctttatcc gaaaaagaaa atcattgtct 230881 ggggccacaa ttaccatcta cgcaaacaga atacgaagat gataaaggac tgggtacagc 230941 taaacggccc taacatgggt gattatttgc cggagcggct gaaaaaacaa acatatacga 231001 ttggcattta tgcttactca ggtgcgagtc ttgatagctc cgataataag actgttaagc 231061 cggttacaag cccgccgccg tctgggagcc ttgaagcttt gctgaaagcg gcggaccgac 231121 cggctgtttt tgttgatttt ctccatacaa aaaacaagaa aggcacttcg tggatgtata 231181 ccccgcggac tgcgctctat tgggggtaca tggaagagca gatgatcctg aaggaacaat 231241 atgacggtgt catttggctg gagcatatca cgccctctgt cattatcaag tgagcggtgt 231301 cccctgtggt aaacagggga tttttacata tcgcaaaaat aatcaaaaca tataatccgt 231361 gatccattat tctaaaacag aaaggagatt ggagcgtgca atgtattatg aaaaagctgt 231421 ccagaaaaca atcaattgga ttgaatcaca tttacatgag caaatatcaa acgaggatat 231481 tgttaacgtt tcaagctttt caaaattcca ttttcatcgg atttttcaaa aagaagtcgg 231541 catgtcggtt gcttcttata ttcggttaag acgtcttgcg aatgcggcgg cagctttgct 231601 ttatacagat catcgtatta tcgatattgc tttgtattat cagtttgaat ctcaagaagc 231661 atttacgagg acgttcaaaa agatgtatca catgccgcca ggagcatacc gaacatttat 231721 gaaacgcttt acttcaaaaa aggaggaatc ttacatggag aaaaaaatga aaggctgggt 231781 attgagcggg agccatccgt tccaattcga aatggggatt gaccgggaaa atgtacatca 231841 gggaaaagct tcagggtatt taaagtcaac gatggttcag gatatcggtg aatttgcgac 231901 gatgatgcag caattcaaag cagatcgcta tctaggaaaa aggcttcgtc tatcaagttt 231961 tatcaaaaca aagggggtgc agcattttgc ctcactttgg atgcgggttg acagtgctgc 232021 tgatgatgtt ctccaatttg ataatatgag caacagacct attaccggaa caaccaattg 232081 gaatcattat gctatcgttt tagatgtccc agaaaatagc gctgtgatat cttttggcgt 232141 tcaattatct gggccgggtc aggtgtggat ggatcatgtt gtttttgaag aggtagatga 232201 gagcgttcct tcaacaaacc ttgaaatgcc gggagaactt ttagatgaac cggtaaattt 232261 atcttttgaa gaggaactac aaaaatagtt ttcagacaac tacttttatt agtgagttaa 232321 tggaaaatac tatttgttat taataaaccc ttgtgctgct taggtttgta agagcttgga 232381 tatttttatc agtctgggcg gatctgttca tctttgcggc attttcctgt atgatatagt 232441 aagagtgtgc atagcaacta actataattg aacagggtgt ttaaaacatg gaaaaacaat 232501 acagagtatt actttactat aaatatgttc cgattgaaga tccagaggcg tttagagagc 232561 agcatctggc tttttgtaag gagcttggtt tgttaggccg tatccttgtt tcttctgaag 232621 gaattaacgg tacggtatca ggtacggttg aacagactga aaaatatatg gaaacaatga 232681 aagctgatcc tcgctttgcg gacatggtat ttaaaattga tgaagcagaa ggccatgcct 232741 tcaaaaaaat cttcgtccgc cataaaaaag agcttgtaac gcttcgtctt gaagatgatg 232801 tcgatccgaa cgaaacaaca ggccagcatt tgaagcctgc agaattttat gagaagatgc 232861 aggatccaaa cacaattgtc atcgacgcgc gtaacgatta cgagtatgac cttggccatt 232921 tcagaggtgc ggtccgtcct gacatcgaag ccttccgtga attacctgaa tggattgaag 232981 agcacaaaga tatgcttgaa ggcaaaaaga ttttaacgta ctgtacaggc ggcgtgcgct 233041 gtgaaaagtt ctcaggatgg ctggtgaagc aaggctttga agatgtagct cagcttgatg 233101 gcggaatcgt gacatacgga aaagatccag aggtgcaagg caagctttgg gacggccagt 233161 gctacgtatt tgatgaaaga atcagcgtgc ctgtcaaccg tgtcgagcat gtgattgtcg 233221 gcaaggacta ctttacagga gaaccgtgtg agcgttatgt gaactgcgca aatccatctt 233281 gcaataaaaa aatgatatgc acaccggaaa atgagtataa atatatgcgc agctgcagcc 233341 acgaatgccg cacgaaccca agaaacctgt atgtgaaaga gcataatatg acagaagaag 233401 aagtaaacgc aagactggca gcgattgaaa cagaagatca cgctgctgct gaataaaaaa 233461 agaacacctc gtattgaggt gttctttttt tctatatgct ttcagtttgg ctgtttgcgg 233521 aaacccattc tttttggcgg aaggcctttt cccattttga taccacgata caggcgatcg 233581 catgtcccgg tacgttcacg cctgttctcg ccatgtccat gacgcggtca acacccgcga 233641 taatggcaac gccttcagcc ggcagtccta cagcattggc agtcgccaga agaactacaa 233701 gcgatcctga gggtacagct gcaatgcctt tactggtcat cacaagcaca agcatcatga 233761 gcagctgctg ggacaatgtc atgtctactt gaaaggcctg tgcgagaaag atacaagaaa 233821 ccgataaata taagctggag ccgtcacagt tcaatgacaa gccggaggga acgacaaatg 233881 ataccactcg tttgggacag ccgtatttct ccattctatc catcagctga gggagaatgg 233941 tttcagtgct tgtggtggaa aatgcaatta aaaacagatc ccatatcatt ttcaatactt 234001 cgaaatactt aatctgaaag atgagaccga caagcggaaa gaggacaaag aggatcagga 234061 acaggccaag gaatacggtg ccaaccagct taaacatagg gaggaggagt tcaatgccat 234121 attggcctac agaagcagcc atcagggcta acacgccgat aggagcagtg accatgacga 234181 tttgcgtgag cttgaacata atctgagctg tagattcaaa aaacttcatt actggttcag 234241 aagctttgcc gataccagct gcggcgacac caaataaaat ggcgaagaaa ataacggcaa 234301 gcaaatcatt tctggccatg acatcaataa tgtttgtagg gataatatcc aggatcattt 234361 gcttgaaatc aacaactttg tctgtgtagc cggaaagttc atgaatatct ttttttgcca 234421 aatgggagag gtcaagcccg acacctggtt ttaagacatt cgctaataaa agtccaagcc 234481 ctaataccaa cgttgtaatc acttcgaacc aaatgatcgt cttgatgccg agactgccca 234541 tttttttcat gcttccgctt cctgcggctc caatgacaat ggtagaaaat acaatcggca 234601 caacaatcat tttaatcagg cggataaatc catctccgac aggcctcagt gccatcccga 234661 aatcaggaaa aaagtggccg atcaccgcgc cgacagccaa agcgattaaa atttgaaacg 234721 cgattaattt tttcaaatga atcccccttt agaacgatag aatgtaggca tattcatatc 234781 attcgtgatt caaatgcaaa cacctttttt caagttattt tattttgaca gcgctttcat 234841 tatgttggcg aaaaagtccc ccgcagcagg ggggactttt ttacttcatt tgaatgtgct 234901 ttagatcttc ttcagaggta tttgtgaaaa taaccggtgt tatggctgaa gcggcatgct 234961 gcttgatgta attgagatca aaggtgagaa gcagttcgcc ttgtttgacg gcttgtccgc 235021 ttgtgacatg tgcttcaaag ccttccccat tcagtttgac ggtatcgatg ccgacatgaa 235081 tcaggatttc agtgccgccg gcgctcataa agccgatggc gtgttttgtc ggaaaaatcg 235141 agacgatctc gccgtccgca ggtgcaacga cttttccttc tgatggtata atcgcaaatc 235201 cctcgcccat cattttttct gaaaagacct gatcaggcac atcccctaaa gagactgttt 235261 ctcctttaat cggataaata aaggtctcat cggaatcggg cttcagcggt ttgtcagtta 235321 ccgtgtccag cgcggcggcg gtggcaggga cgcctccggc catgattgtt ttgatgtcgt 235381 cttttaaggc atcggacttg gttccgaata ttgcctggaa gttgttgttg acctccagca 235441 cacctactgc accaagccgt tttaattcat ccttgcagac ttggcttggc tgatgaacgg 235501 tcacacgaag ccttgtgata catgcatcca ggttagcgat attttgctgt ccgcccaagg 235561 cctgcagcac gtgaaaggca agctggtctt ttgcaactgg agctttctcc tcattctgac 235621 cgtcttcatc tgtctcacgg ccgggcgttt tcaaattcca tttcagaatc gcaaatcgga 235681 acaaataata ataaatgaaa gcaaacacga tcccgacagg aatgacaacc cagccgtttg 235741 tagacagtcc gtagttcaag acgtagtcaa ttcctccgcc tgagaacgta tagccgtggc 235801 ggacatggaa taaatcacaa acgacaaaga tgacgccggc aagaatagag ttaatcaaat 235861 agagcacggg cgcaacgaac aagaaagaaa actcaaccgg ttctgtaatt ccggtcagca 235921 tagatgtgag cgccgcagaa atcatcacgc cggagatcat ttttttcttt tccggacgcg 235981 cggtatggat aatggcaaga gcaacggccg gcagacagaa aatcatgtaa gggaaatccc 236041 ccatcataaa gcgcccggct gtcgggtctc ccgcgaaaaa ccttgtcagg tcgccggtta 236101 cggtgttgcc tgttgatggg tctgtgtatt ctcccatcat aaaatagaaa ggcgtataaa 236161 aaatatgatg caggccaaaa ggaatcagca aacgatagat cgttgcataa aagaacaggc 236221 cgactgttga atcggcaatt aaactgctgg ctgcgttaat tccgttttgg atcagcggcc 236281 aaacgaatga gaaaatgacg ccgatcacca atgaactgac ggaagtaatg atcgggacaa 236341 agcgttttcc agagaaaaat ccaaggaccg gatgcagctc gattgatgaa aatcgcttat 236401 ataaataggc ggcgagaagc ccgataatga ttcctccgaa aacccccata tcaatcaggt 236461 gctcggctcc ttcatacgga ggctgaaggc cgagtaattt tcccatattg tcgagggtga 236521 cggttaaaat taagtatccg atgacagcgg caagtccggc tacaccttct ccgccggcta 236581 atccgatcgc gacccccacg gcgaaaatca gcggaaggtt atcgaataca acgccgcccg 236641 catcctttat aatagggatg ttcagtaaat ccttgtctcc gaaacggagc aaaagacctg 236701 ctgccggcag gacggcaacc ggagtcatca acgcgcggcc aagctgctgc agaatttgaa 236761 atgccttttt aaacatgaca gtctcctttt attgtgttat gagaatgatg cactctttaa 236821 tttttgagct gctttataat cggcgataac ggttacatga ttgtgttttt gaagaatgga 236881 ggctggtaca tctgtcgtga caggaccttc agccatcttt tgaatggcgt ctgctttttc 236941 ctcgccgctt gctaaaagca caatatgttt gctgaattcc atgatggttt taatgcccat 237001 tgaaatcgcg agtctcggaa ccagcaccgg atcgccgccg aagaatctgg catttgcctg 237061 tatcgtgctt tccgagagct tcacaacacg tgtccggtct tcaaaatcag atcccggttc 237121 attaaaaccg atatggccat tggcgccgat gccgagaatt tggacatcaa tgcctcccgc 237181 ctggcggatg agatcctcgt atactttgca tgccgcctca agctgcggat tgtctccttg 237241 cgggatatga atatgatcag gctgcatatt gatatgctga aaaagatgct catgcataaa 237301 atggttataa ctttgcggat gagatggaga gagaccagca tattcatcca aattaaatgt 237361 agtaaccttt gaaaaatcaa tttcgcctgc ctgatagtct gaaatcaact gcttatacaa 237421 gccgaccggt gtgcttcctg ttgccaggcc gagaacggca tctttcttag cttgtatttg 237481 ttctttaata atggcagcgc ttaacttaca gagttcttcg tagtgctcgg cgatcagaat 237541 cttcatgtga caccccctca aagagataga caagcaccat atttgttatg accaatttat 237601 gatacttgtc attacgaatt tagcaccgcc cttatcaaac tgtcaatatt aatttctgaa 237661 aatttgttat aaaagaagga tacaaatctt tcatattggg agggcaaatg gtattatggt 237721 ctcaatgaaa aagaacggat tgcatacaga atggggagaa tgaaatgaca gctttatatt 237781 ctgttatcaa gtttaaaatc attgagttaa ttaaatcggg caaatatcag gcgaatgatc 237841 agctgccgac ggagagtgag ttttgcgaac aatatgatgt cagcagaaca actgtgagac 237901 tggctctgca gcagctagag cttgagggat atattaaaag aattcaagga aaagggacat 237961 ttgtatcggc ggccaaaata caaacgccga ttccgcataa gattacgagc tttgcagaac 238021 aaatgagagg acttcgttct gaatcaaaag tgcttgagct tgtggtgatt cctgccgatc 238081 attccatcgc cgagcttttg aaaatgaaag agaatgaacc tgtcaacaag cttgtcagag 238141 tcagatacgc cgagggggaa cctttgcagt atcatacctc atatattccc tggaaggcgg 238201 caccggggct ggcgcaggag gaatgcaccg gctcgctgtt tgaattgtta aggacaaaat 238261 acaatattga aatcagcagg ggcacggaat cgatcgaacc gattttaacg gatgaaacga 238321 tcagcggaca cttattaacc aatgtcggag cgcctgcgtt tttatcagaa tcccttacct 238381 atgataaaaa tgaagaagtg gtggaatatg cgcaaattat tacacgggga gaccgaacga 238441 aattcaccgt agaacagtca tatcattcat aaagcaatgt gttttaagaa gggaatggtg 238501 gttctatgtt tttatttacg aatggaaaag tgctgtgggg agcagtgatt gctgcattca 238561 tcctttcaat tgtattttac ccttttctgc cgacgcagat gccgattcat tatgatgttg 238621 cgaacagtcc ggatctgacg gttaacaagc tggcggggac tgtgatgctg cctgttttga 238681 tggtggtgtt tgcatgggcg cggaagatca attggcaatt tgtattcgca gtgtatattt 238741 tgctgatttg ccacattgtc gtcctttgtt tagcgctcta aatcaaacag ccagaataaa 238801 actggctgtt ttctttaatt tcagcttcat ctgacaatga atgtggtgta taatagctga 238861 tgatcctaaa gaatattctg aaatttatag gtgtgaagcg gcgtattatt aaaggaaagg 238921 ctgtatactt tttgcagctt taaaaagact gaatatttaa acaattatgt gaaaggtgtg 238981 ctgattagat tgaataagct tattgaacga gaaaaaactg tatattataa ggaaaagccc 239041 gacccgtctt ccttggggtt tggacaatat tttacagatt atatgtttgt gatggactac 239101 gaagagggga ttggatggca tcatccgaga attgcgccgt acgcaccgct tacgcttgat 239161 ccgtcttcat ctgtttttca ttacggccag gctgtttttg aaggattaaa agcatacaga 239221 acagacgacg gcagggtgct gctgttccgt ccggatcaaa atatcaaacg gctgaacaga 239281 tcgtgtgagc gcatgagcat gcccccttta gacgaagagc tggtgcttga ggcattgacg 239341 caattagttg agctggagaa agattgggtt ccaaaggaaa aaggaacgtc actgtatatt 239401 cgtccttttg tcattgccac agaaccgagt ctcggtgtga aggcatccag gagctataca 239461 tttatgatcg tgctttcgcc tgtcggctcc tattatggcg acgatcagct gaagccggtt 239521 agaatctatg tcgaagatga gtatgtgagg gcggtcaacg gaggagtcgg gtttgcaaaa 239581 acggctggaa actatgccgc cagtcttcag gcacagcgga aagcgaatga actgggctat 239641 gaccaggtac tgtggctgga cgccatcgaa aagaaatatg tggaagaagt agggagcatg 239701 aacatctttt tcgtcataaa cggggaagct gtcacacctg ctttaagcgg aagcatttta 239761 agcggggtta cacgtgcgtc tgcgattgaa ttgattcgaa gctggggcat tccggttcgt 239821 gaagagagaa tatcgattga tgaggtgtat gcggcctctg cacgcggaga attgacagag 239881 gtctttggca caggcacggc agcagtcgtt acgcctgtcg gtgaactcaa catccatgga 239941 aaaacggtga ttgtaggcga cgggcaaatc ggggacctct cgaaaaagct gtatgaaacg 240001 ataacagata ttcagcttgg caaggtaaaa ggcccgttta actggacagt ggaagtgtga 240061 aaatcgaaaa agaacctgcc cggaggcagg ttctttttat tttgaatgag tcatatcagc 240121 agccggctgg cttttgcggt tttttacata atatattgca tagcaaatgg ccataaatgg 240181 aacgccgcaa tagagtgcga ttctttgatt cggatcaaag gcaatgccaa cgacggaagc 240241 caggcataac aggaacgcag caatcggcac gaacggatac aaaggggttc tgtatttcaa 240301 atcagtaacc ttgtttcccg cttcgatata acgttttctg aacatgaatt gagaagcagc 240361 gattcccatc cacacgacaa cgacggcaaa accggaaatc gacacgagca caacgtatac 240421 agtgtctggc gcaaatacgc tggacagcaa cgacagaatg ccgccgatca tgctgaacac 240481 cagcgcgtta aaaggggttc cttttgacgt cagctttgca aatgtcggat gaagcgtttt 240541 ttcttttgat aaagaccaca gcatccggga agaagcgtag agtccggaat tagccgctga 240601 caggatcgct gtcaggataa caaagttcat gatatcggct gcgtatggta caccgactct 240661 gtcaaagaca gcgacaaacg ggcttttgat gacacctgca tcttgaatcg gaatcagccc 240721 tgacagcaca aaaattgttc cgacaaagaa gagcgagaga cgccagaccg ttgtttttat 240781 cgcttttggt atcgtcttgt caggatcaac gctttcaccg gctgcgattc cgattagttc 240841 cgttcccgaa aaggcaaaat tgacggacag catcgtcatc aaaatcggga caaatccatt 240901 gggaaaaagc ccgccttccg ccgtgaagtt ggacagcatc ggagcggctt ctccgccttt 240961 gatcgggatg atgccgaaca tggcagagcc gcctaaaaga ataaataata caatggctaa 241021 tactttgatg ctggaaaacc aaaattctga ttcagcgaaa aacttgaccg aaaatgcgtt 241081 aagcaagaag atgaacagcg caaagacggc actccacatc caaaccgatg tatgggggaa 241141 ccagcgctgc attaacaggc cggctgctgt gaattctgat cccaatgcca cggtccatgt 241201 cagccaatac agccaagcga ccgtaaatcc ggtgcccggc cctatgtatt tggctgcata 241261 ggtgtgaaag gcgccggtca caggcatggc gactgacagc tcaccgaggc atagcatgac 241321 cagatagacg atgccggccc cgactaagta ggcgagtatc gttccggccg ggcctgcttg 241381 ctgaatggta taacctgagc ttaaaaacag cccggttccg atgacacctc ccaaggaaag 241441 cataaagagg tgccggcttt tcatacttct ctgaaaggtt gtctcattct tgttgtgggc 241501 agagttcatc tttttccaac tttctatcag cgatttattt ccttcctaat aaaaaatctc 241561 atgtcagaaa gtgacacgag actccggcga accggcttta agttagaata tacaaactat 241621 tccgataagt caagttgttt ttaaagagcg ggcccaagcc gcaatttctt gaatattttc 241681 gggttttgtc cggcagcagc cgccaatcag cctcgctcct ttttcatgcc aggtgcgggc 241741 gctcgccccg taagattctg cgcatgctgc gccgttccac gtttttgttt ccggatcata 241801 ttgctcacct gaattcgggt agacaatgat cggttttgac gtgttctttt ttaactcctc 241861 tatcaaggaa gggatatgct gaagcggcgt gcagttgatg ccgagtgctg caatttggcg 241921 gtgttcatca agccacgatg cgcagtcagc tgcaggtgtt ccgtcactga tatgcaagcc 241981 gtctttagca ctgaagctga tccatgcata cgtttcagga aattccttca acagccgaac 242041 aatcgctttg gcttcagtca gacacggaat cgtttcgcat gccaatacat cagctccggc 242101 ttcaatcagc gccttcatcc gggggcgatg aaattcaatc agttcatctt ctgatattgc 242161 gtagttgccg cgatactcag acccgtctgc aagataagcg ccataagggc ctatagaagc 242221 cgcaatgatc ggttttggcc gattcaaacg gttctcttca agcgaccaaa attcatcacg 242281 tgcttcagct gcgatgctga cggacaactc gatgagccgg cgtgcttccg cttcgctcag 242341 cccgcgtgcg gcaaagcctt caaatgtaga ctgatagctg gcggtgattg cacaatcggc 242401 gcctgccgca aaataatcag tatgaacttg tttaatcagc tccggctctt ccatcaggat 242461 ttttgccgac cacagactgt cattcaaatt acagcccttg cgttcaagct cggtcgccat 242521 ggcgccgtct agcacaataa gcgggtatgt atctaatatg tgttggatag gattcataga 242581 atgtaccgat gccttctttc agattttttt gaaaaagata tgaaaatcgt aatggaggct 242641 tacgtgtttg tcaataaacg caaaaagaga aaggtgttca gcccatatgt ctgaacaccc 242701 ttttcttatg atatttgttt gttgtgcgtg tcagtctttg tgtctgaaac cggccagcac 242761 tcaatgccat tatggttttt gagcacatct ttataaaaga ccggatcctt gcctgctttt 242821 ttctggcgtg tatagtcttt cagcgccgta aaaacgacct ttgatagtaa gaaaatcgcg 242881 attaaattca cgatgaccat caaacccatg aacaaatcag caagatccca gacgagctgg 242941 actttggcaa cacagccaaa cacgatcatt gccagcacgc cgatacggta gacaaaaatc 243001 agttttttgc ttttgttcaa aaagccgata ttggtttcgc cataataata gtttccaatt 243061 agagcacaga atccgaataa caaaatcaga atcgcgagaa agcctgatgc ccatgatccg 243121 acatgggagc tgagggaggc ttgtgtcaag gcgattccgc tcagacccgg agtatgatag 243181 gcatccgaaa acagaatgat aaaagcggtg cttgtacaaa tgaccagtgt atctgtcagt 243241 acaccaaaag cttggatcag cccctgtttg acgggatggc ttgttgtggc ggtggcagcg 243301 gcatttggtg cgcttcccat tcccgcttcg tttgaaaaga ttccccgtct gacgccttgc 243361 atgagtgccg cgcccaaagc cccgccggcg gcctggtcaa aaccaaacgc atttttcacg 243421 attagcgcaa gcacacctgg cagctgcgta atgttggaga aaatgacgaa aaacgcaact 243481 ccgatataca ggacagccaa tacgacgaca atggattcag ccagctttgc aatgcgcttg 243541 actccgccaa aaataatcgt gccgaataca gcaattaaaa tgagtcccaa tgtcaggcgg 243601 tttgtgccaa acgcgttttc aaaggcaagg ctgactgtat tggattgaac cgagttgaag 243661 acgataccga acgataaggt gattaacaca gcgaacagcg cgcccatcca ccttttgttc 243721 agcccttttt ccatgtaata cgccggcccg ccgcggaagc cgtttacatc ttttacttta 243781 taaatctgag ccagtgtgct ttccacaaag ctggatgctg atccgataat ggcgataatc 243841 cacatccaga agattgcacc gggcccgccg agtgcaatgg cgatagcaat gcccgtaata 243901 tttcccgttc cgacacgggc cgccatgctg atgcaaaagg cttgaaacgg agaaatgctg 243961 ttttttgacc gggaagcagc accttctctt aataccctga ccatttcttt cagcatgcga 244021 acctgtaaaa acttaagcct gaacgtaaaa tagattccaa aagaaaggag caaaacaatt 244081 aatagctttg accacaaaag atcatttgca ataccgacga tatgttctag gatttgctgc 244141 atagaatcac ctcttttttc atgtttaaaa aatgctgagc tcccattcct gcgccatatg 244201 cttcagcagc ataccgccag tgaggctgtt gccgtattca tcaatggcag gcccgtaaat 244261 gccgatgccg catccggatt gaaaaggctg ttctcttctg gcgcttggag gcaccagcgc 244321 catgatgccg ccggagacgc cgcttttggc cggcacgccg acaaacgccg catatttgcc 244381 tgaagcgttg tacatgccgc acgtcagcat taatgccttg gccaattttg ccacatcttt 244441 tggaatcacc tgctcgtgtc gaatcggatg atacccgtca tgagcaagga tcaggccgat 244501 caacgcaata tcttctgtag tgctctccat agcgcattgc ttcaagtaca cctcaagtgt 244561 ttcttctact tcagcttcta aaaagtttgt ttcttttaaa tagtaggcca gcgctctgtt 244621 gcggtgggcg gtttcccatt cagaacggaa tacttcttca tgaattcttg gccgttttcc 244681 tatcaaagtt tccatcaccg agtaaagaaa ctcgagcttt tcgtatgcag attctccggg 244741 aaggatcgaa gcgatggtga gggcacccgc gttgatcatg ggattgaagg gctttcccgg 244801 cttgttgatt tcgagccgaa tgattgaatt aaaggcgtca cctgtcggct cgacatctac 244861 gcggtcaagc acatagggaa tgccgcggct catgcaggcg gcaataaagc taatcacttt 244921 tgaaatgctt tgcatggtaa aagagacgtt ccagtcgccg gcgtgtatca tcgttccatc 244981 aggctccaat acacagatgc cgagctgtga atcattgact tttcctaaag cggggatata 245041 gtttgcgctt tgtccattgg cggcaaaagg gcgatagtat tcaacccaat catgaagctg 245101 taacgccggg tttatgtctt tctggtgctc ttttatcaat tctttcatcg aattcctcct 245161 cactgatttt tttcttaaag gactgaggtg tatcaaaacg aaggctaagg gggcgttaaa 245221 cgctttcata atagcggaag gtataattac tgtataatgg agactacaga atcatacaaa 245281 atacgacaaa aacattttga aaataagcag taagatttat aaaaacctca tgttctgggt 245341 caaaagcaat ttgcaggttt tctcccgatt ccccaaaata aaaagcgagg atgtgatcaa 245401 cataaaactg gaacggttta ttgaaaaaga cggatatata ctggccctca tgctgattac 245461 ggtgccgctg gccggtgaac tgaaatttta tcccctcaat gaagaattcc gggtcagctt 245521 tggggcaccg gtttttttct tctttttatc attgttgcgg catgtgcccg ctgtgctgcc 245581 gggttttctg actggagcgg ctgttttcat ctttcgcgtc tttctggaat tatggggcgg 245641 aggacacaat gggctgactc cgattctgta tgatcaagcg tctggctttt tcttttatat 245701 gacttacgcc tgtctgtttt ccatattaaa ggccaatcgt ttccgtgaac ggccgattat 245761 gctcggtttc attgggttta tgattgaagt tgtgtcagat tgtgtcgagc taactgtgca 245821 atttctcatt tttcatacgg ttgtcacgcc tgagaaaatc actgacattg cggtgattgc 245881 gatttctcac acatttattg tgatgagctt ttatagtgtg ctgaagctgt atgaaacaca 245941 atcgagagaa aaacagacaa ggcagcagca cgagcacatg ctgatgatcg tttccaattt 246001 atatgaagaa acggtgcacc taaaaaagac attgaaaacg acagagaaag tgacaaacga 246061 ttcgtatcag ctctatcggg aaatgaaggg caaggatgtt cagctgagcg gcagaatcct 246121 gagactggcc ggagagattc atgaagtgaa aaaggacaac cagcggatat tcgcagggct 246181 ttcaaaactg atttcgaatg agagtttgag agattatatg agggcttctg atttgctgca 246241 gctcgtgatt cgaatgaatg aaaagtacgc tgaagcacta gggaagcaga ttgattttta 246301 ctgctcgatc gagggagagc atgacgaata tcacgtattt atcgtgcttt cgatcattaa 246361 taatctaaca gcaaatgcgg tagaggctat ggatgaagag ggaatggtca gcctgaggct 246421 ccgtaagcca aatgagagta tggtagaatt ccaggtggaa gacaatggcc ccgggatttc 246481 cgagaaaatc ggagacattg tgtttgaccc gggctttact tcaaaatatg acgaatttgg 246541 cacgccttct acgggtatcg gactttccta cgtaaaggaa atcgtgacag agctagaagg 246601 ggatatcacg tttgataatc agcagcgggg agtggtgttt gccatcaggc tgcctgtccg 246661 gcatttgatt cagaaagggt gaaccaaaag ctatgcgttt ttttattgca gatgatgacc 246721 gtgcggtgcg gtcaatttta aggcagatca ttgaggacga agatctcggg gaagctgctg 246781 gtgaagcaga cgacggaagc caagtggaag ggcatatgct gcaatttaag cagattgata 246841 ttttattaat cgatctgtta atgcccggaa gagacggcat tgagacgatt cgtcagatcc 246901 agaatacgta ctccggcaaa atcgtaatga tctctcaagt ggaggcgaag gaaatggtcg 246961 gggaagcgta ctcgctcggc atcgaatatt ttatccataa gccgattaac cgcattgaaa 247021 ttgtcacggt tctccaaaag gtgaaggagc ggatcgagct tgaacactcg attggagcca 247081 ttcagcattc tctaagccgg cttgtcaatc ggactgaacg gaaagcgcgt ccccagcaga 247141 agagtgacag cggtttaaaa gaggcaggaa cattcctgtt gtccgagctg ggcatgatgg 247201 gagaaggcgg cgcacatgat ctcatggcgg tcctgcagta tttagcagaa cacgagcaat 247261 ccgagccgca cgaaaaacaa agcccttcgc taaaacaaat attcacccaa gtagcggtac 247321 ggaagctggg gacaggagcc tcacagacgg aagtcaatcg cgaaatgaaa gcctcggagc 247381 agcgtatccg cagagcgatt attcattcgc tgcaccattt tgcttcactg ggcacaactg 247441 atttttcgaa tccaaaattt gaaacctatg catcgaaatt ctttgatttt ccggttgtca 247501 gccagaaaat gaaagaactc caatccaagg atgcaaaacc ccttgcacct gctagaataa 247561 atatgaaaaa attcatccac gtgttttttt tggaagcaaa gcttttgcat gagacgatga 247621 aacaaagaag gatataaacc aaacagccgg ctgaccaggc tgtttttttg ctgcgcagaa 247681 tcccggccgg acagtgattt accgcttttt tataaaatat cagaaaataa agatattgac 247741 ttattgttta tttgtcttac aattaaacaa aaggatatat gggaaggagc ggatgtgaaa 247801 gaaaaattaa taaaagcgct tacagataga ggccgtatac acaaataaca ggaggttatg 247861 ttgatgagcc gtatcagaaa agcacccgct ggaattttag gttttccggt tgctcctttt 247921 aacacacaag gaaaactgga ggaagaagct ctttttcaaa acattgagtt tttgctgaat 247981 gagggcttgg aagcgatatt tatcgcttgc gggtctggtg aattccaatc tctcagccag 248041 aaggaatatg agcaaatggt ggaagtcgca gtctcggcag ccggaggaaa ggtgccggtc 248101 tacacggggg tgggcggcaa cctcagcaca gcgcttgatt gggcgcagct gtcggagaaa 248161 aaaggcgccg acggctactt gattctgcct ccgtatttgg tgcatggcga acaggagggg 248221 ctgtaccagt atgcgaaaac gattattgaa agcactgact tgaacgcgat tctttatcag 248281 cgcgataacg cagttctctc tgttgaacag atcaaacgtc tgaccgaatg tgaacagctt 248341 gtcggtgtca aagacggggt aggaaatatg gatttgaata tcaatctcgt ctatacgatc 248401 ggcgaccgct tgggatggct caacggaatg ccgatggctg aagtgacgat gccggcttat 248461 ctgccgatcg ggttccactc ttactcttca gcgatttcaa attatatccc gcatatttcg 248521 cgaatgttct atgatgcatt gaaaaacgga aatgacgagc ttgtgaagga actctatcgg 248581 catgtgattc tgccgatcaa cgacattcgc aaacaacgaa aaggctacgc cgtatccttg 248641 attaaagccg gtatggaaat catgggtttg aatgtaagga atacagccag accgcctgtc 248701 ggcccggttg aaaaagatca ttatcagcaa ttggaagcaa ttttgaagca ggcggctgac 248761 cgttttccga aaaaagccgc gacggtttga ccagaaaaaa cacgaaaggg gcaatgggca 248821 tgtctgtgat cacggaacaa aacacgtacc tcaactttat taacggagag tgggttaagt 248881 ctcaatcagg cgatatggtc aaagtcgaaa accctgccga tgtgaatgat attgtcggat 248941 atgtacagaa ttcaacggct gaagatgtgg aacgtgccgt caccgccgcc aatgaagcca 249001 aaacggcttg gagaaagctg acgggtgccg agcgcggcca atacttatac aaaacagcgg 249061 atatcatgga gcagcgcttg gaggaaatcg ccgcctgtgc aacgcgtgaa atgggtaaaa 249121 cattgccgga agcgaaggga gaaacagccc gggggattgc cattctgcgc tattacgccg 249181 gagagggcat gcgaaaaacg ggtgacgtca ttccgtctac tgacaaagac gcgctcatgt 249241 ttaccacccg tgttccgctc ggtgtggtcg gtgtgatttc tccgtggaac ttcccagtgg 249301 cgattccgat ttggaaaatg gcgccggcat tggtatacgg caataccgtt gtcatcaaac 249361 cggcgacaga aacagctgtg acatgcgcga agatcattgc ctgctttgag gaagcggggc 249421 tcccggcagg ggtcatcaat ttggtgacag gcccgggttc tgttgtcggg caggggcttg 249481 ctgagcatga cggtgtaaac gccgttacgt ttaccggttc aaatcaagtc ggaaaaatca 249541 tcgggcaagc cgctttagcg aggggagcca aatatcagct tgagatgggc ggcaaaaacc 249601 ctgtcatcgt agctgatgac gctgaccttg aagctgcggc agaagctgtc ataacggggg 249661 ccttccgttc aaccggccag aaatgcaccg cgacaagccg tgtcatcgta caaagcggaa 249721 tttacgagcg ctttaaagaa aaactgctcc agcgcacaaa agatattaca atcggagaca 249781 gcttaaaaga ggatgtctgg atgggaccga tagccagcaa gaatcagctt gataactgcc 249841 tgtcatacat tgagaaaggc aaacaggagg gcgcttccct tttaatagga ggagaaaagc 249901 tggagaacgg aaagtatcaa aacggctatt atgttcagcc tgccatcttt gacaatgtga 249961 catctgagat gacaattgcc caggaggaaa ttttcggtcc ggtgatcgcc ttgatcaagg 250021 tggactcgat agaggaggcg ctgaacatcg ccaatgatgt gaagttcggt ttaagtgcat 250081 ccatcttcac ggaaaacatc ggccgaatgc tttctttcat tgatgaaatc gatgccgggc 250141 tggttcggat caatgcagaa agcgcaggtg ttgagctgca ggcgcctttt ggcggcatga 250201 agcagtcgag ctcccactcc cgagaacagg gtgaggcagc gaaggacttt ttcacagcga 250261 tcaaaactgt ttttgtgaag ccgtaatggt gctggaaaga ggcgtgcgtc tctttcccgg 250321 tttatcacaa ccagcatatg attctctact ttgaaaagga gaagatacta tgaaaaaaga 250381 ctttgcgagt gttactccgg cgggcaaaaa aacgtccgtg cgctggttca tcgtgtttat 250441 gctgtttctt gtgacctcta ttaactacgc ggatcgagcg acgctttcca tcaccggaga 250501 ttccgtccag cacgatttgg gattggactc ggtcgccatg ggatatgtct tttctgcctt 250561 tggctgggcc tatgtcatcg gacagcttcc gggcggctgg ctgctggacc gttttggttc 250621 aaagactatc attgcgttaa gcatcttttt ctggtcgttt tttacgttgc tgcaaggggc 250681 gattggcttt ttctccgccg gcacagcgat tatcctgctg tttgcactgc gttttctggt 250741 tggtttatca gaagcgcctt catttcccgg aaacggcaga gttgttgcct catggtttcc 250801 aagctccgag cgcgggacag cttcagcctt ttttaattca gcacaatact tcgcaatcgt 250861 cattttttct cctttaatgg gctggcttac ccactctttc ggctggcatt ccgttttcgt 250921 tgtcatgggt attgcaggca ttcttctggc tgtcatctgg ctaaaaacgg tgtatgaacc 250981 gaaaaaacat ccgaaggtta atgaagctga gcttgcgtac atcgaacagg gcggcgggct 251041 gatttccatg gatgacagta aaagcaaaca agaaacagaa tcgaaatggc cgtatatcaa 251101 acagctgtta acgaaccgca tgctgattgg cgtgtacatc gcgcaatact gtattacgac 251161 tctcacctat ttctttctca catggtttcc ggtatatttg gttcaggccc gcggcatgtc 251221 tattcttgaa gctgggtttg tcgcttccct gccggcgctg tgcggatttg ccggcggcgt 251281 gcttgggggc attgtgtcag acatcttact caaaaaaggc cgttcactga cctttgcaag 251341 aaaagtgcca atcattgccg gcatgctgct gtcttgcagt atgattgtct gtaactacac 251401 agattcagca tggctcgtcg ttgtcattat gtcgctcgcg tttttcggaa aaggcttcgg 251461 cgcattgggt tgggctgtcg tgtcggacac gtctccgaaa gaatgtgcag gattaagcgg 251521 cggtttgttc aacactttcg ggaatattgc ctcaattaca acaccgatta ttatcggata 251581 cattgtcaat gccactggat ctttcaatgg cgcgcttgtg tttgtcggcg ctaacgcgat 251641 tgcggcgatc ctcagctatt tgctgctggt cgggccgatc aaacgggtcg tgttaaagaa 251701 acaagaacaa gaccccgatc aatcgttgcc tgtctaatat ttatgaaagc gctttataaa 251761 gggaggaaaa tgcatgagtt caccgataca agagcaggtt caaaaagaaa aaagatcgaa 251821 tattccctca atttctgaaa tgaaggtgat tcctgttgcg ggacatgaca gcatgctgct 251881 gaatctaagc ggagcacaca gcccgttttt tacccggaat atcgtaatct taacagacag 251941 cagcggaaat cagggagtcg gcgaggtgcc tggcggagag catattcgcc gcacactgga 252001 gctgtcagag ccgcttgttg tcggaaaatc tatcggtgcg taccaggcga tattgcaaac 252061 ggtcagaaag cagtttggcg atcaggacag gggagggcga ggaaaccaga cgtttgattt 252121 gcgcaccact gtgcacgccg tcaccgcact ggaagcggct ttgttggatt tgcttggaaa 252181 gtttcttcag gaaccggtcg cggctttgct gggcgaaggg aagcagcgtg atgaagtaaa 252241 aatgctcggt tacctctttt acatcggcga ccgaaatcgg acgaccttgc cgtatcaaag 252301 cgatgagcag tcagattgtg cgtggttccg tctgcgccat gaggaagcgc tgacgccgga 252361 ggccattgtg cgtcttgccg aatccgcaca ggagcgctat ggctttcagg atttcaaatt 252421 gaaaggcggg gtgctgcggg gagaagagga aatcgaagct gttaccgcat tatcgaaacg 252481 ttttccagag gcaaggatca ctcttgatcc gaacggggca tggtcattag aggaagctat 252541 tgcattatgc aaaggaaagc aagatgtgct cgcgtatgcg gaagatccat gcggggatga 252601 gaatggctac tccgctcgtg aagtaatggc tgaattccgc cgcgcgacag ggcttccgac 252661 tgcgacaaat atgattgcga ctgactggcg ggaaatgggt cacgcgattc agctccacgc 252721 ggtcgatata ccgctggctg atccgcattt ttggacgatg caagggtcgg tgcgggttgc 252781 gcaaatgtgc catgattggg gtttgacatg gggctcgcac tccaacaacc actttgatat 252841 ttcccttgcg atgtttaccc atgtggcagc agcggctccg gggcggatca cggcgattga 252901 tacccattgg atctggcagg acgggcagcg attaacgaaa cagccttttg agatttcttc 252961 tggctgtgtc aaggtgccgg ataagcctgg actaggcgtc gatattgata tggaacaagt 253021 ggaaaaagcg catgagatct atcggaaaat gaatttaggc gcacggaatg atgcgatccc 253081 aatgcagttc ctgatcagca actgggaatt tgaccggaag cgcccgtgtc ttgtgcgata 253141 agtttgattg taaatattgt catatccgct attttgtctt acaattgaac aactgaaggg 253201 agagttgttc gtgtacgaag gtttagagga tttgaaagtc gatacagtca atcggaaaac 253261 attagccaag caggtcatcg aacggattgt ccatttatta tcgagcggac agttgagggc 253321 cggagacaaa ttgccgacag aaatggaact gatggacatt ttgcatgtca gcaggccggt 253381 gctacgggaa gcactcagtt cacttgaaac gctgggcgtc attacgagaa aaacacgagg 253441 gggcacatat ttcaacgata aaatcggcat gcagccattt tccgtcatgc ttgctttggc 253501 cactgataat cttccggcta tcattgaagc gcggatggcg ctagaactcg ggctcgtgac 253561 aattgccgcg gaaaaaatca atgaggaaga gcttcagcgt ttgcagaaga cgatcgacga 253621 tattgccaac agcactgaca atcattatgg tgaagcggat aaagagttcc atcgaattat 253681 tgcgttaagc gccaataacc ccgtcgttga agggatgatt cagtccctgc tgatcaccca 253741 tgcgaaaatt gacagccaaa ttccgtacag ggagagagat gtaacggtcg aatatcacaa 253801 aaaaatctac gacgcccttg ccaaaagaga tccgtacaaa gcacattacc acatgtatga 253861 gcatctgaaa tttgtccgtg acaaaattct aaaaggaatg gatgaaaaat aatggtgagc 253921 aaccgcagtt gaaacgtaag agctgcggtt tttttaaacc aatttagaaa acgcttacta 253981 aaatatgagg agtgattttc atatggcgat gaacctcagg aagaaccaag ccccccttta 254041 catcaaagtg catgaaatag ataacaccgc gattattgta aatgatggag ggctgccaaa 254101 gggcactgtt ttctcatgcg ggctcgtact tgaagaggat gttcctcaag gccataaggt 254161 ggccctcacc gatctcaatc aaggggacga gatcgtgcgt tacggagagg tgatcggatt 254221 tgctgatgag acgatcaaac gcgggagctg gatacgggaa gccctcgtga gaatgcccgc 254281 tcctccggcg ttagacgatc ttcctctcgc aaacagggtg ccgcagccgc ggcccccact 254341 tgaaggatat acatttgaag gataccgaaa tgcggatggc agtgcgggga caaaaaatat 254401 cctcggcatc acgacaagtg ttcaatgtgt tgttggcgtt ttggattatg cagtcaaacg 254461 aataaaagaa gagctgctgc cgaaataccc aaatgtcgat gacgttgtgc cgctgcatca 254521 tcaatacgga tgcggcgtgg cgatcaatgc gcccgacgct gtcattccga tccgcacgat 254581 tcaaaatctt gcgaagcatc cgaacttcgg cggtgaagta atggtaatcg gattgggatg 254641 tgaaaagctc ctcccggaaa gaattgcctc cgaaaatgat gatgacattc tatcgctcca 254701 ggatcaccga ggttttgcgg cgatgatcca atccattttg gaaatggcgg aggaacggtt 254761 aatcaggctg aacagcagaa cccgggtgtc atgccctgtt tcggatctgg ttatcggcct 254821 gcaatgcggc ggcagtgatg cgttttccgg cgtgacggcg aaccctgccg tggggtatgc 254881 ggctgattta ttggttcgcg caggtgcaac ggttttgttt tctgaagtga cagaggtgcg 254941 ggatgccatt catttattaa cgccgcgggc tgtcagtgaa gaggtcggac aatcgctgat 255001 caaagagatg aagtggtatg acagctatct tcggcgggga gacgcagacc gtagcgcaaa 255061 cccgtcacca ggcaataaaa aaggcggatt atccaatgtg gtggaaaaag cgttaggttc 255121 ggtagcgaaa tcaggcacaa gccccatctc cggcgtgctc ggccctggtg aaagagcaaa 255181 gcaaaaaggc ctgctgttcg cggcgacacc ggcaagcgat tttgtgtgcg gcaccctgca 255241 gctggctgcg ggcatgaatt tgcaggtgtt tacgacaggg agaggaacac catatggcct 255301 ggctgctgcg ccggttctga aagtatcgac gcggcattcc ttatcagagc attgggctga 255361 tttaatcgat atcaatgccg gccgaatcgc gacaggagag gccagtatcg aagacgtagg 255421 ctgggaaatc ttcaggacga ttttggatgt ggcaagcggc cgcaaacaaa cgtgggcaga 255481 ccgttggggt cttcataatg atttgtgctt gtttaatcct gctccagtga cttgattcat 255541 gtttttatag cggaaagatg gaatatgctg taaaatgaaa atcagcgtat aggaaacgga 255601 ggggttacag catggcattc attagattcc gagtgacacg aattcaatag tgaacaactc 255661 tcgcctgaat gcgagagaat cgggatgaat ccgcctatgt atgagccctt atatggttat 255721 caaaaaagag ggtggcgtgc ctgccctttt ttgtgccttc aagcatccct tctctctact 255781 gcaggccgga gcatgagaaa ggggaaatgg gatgacaaac cttaacgaaa aacagcttat 255841 cactgagatt gtcgggcttg cacgcagcca aggtttgacg gttcattctg agaacgcgca 255901 attgaatgaa accggaatgg actttcaagt tgtatttgcc aaggacgaca caggtatgcc 255961 atgggtgctg cgaaaaccgc ggcgaagtga tgttgtggaa agagcatctg cagaaggcat 256021 aacgcttgcc tttctccgcg cgaatctgac tgctgatgtg ccggattgga gaattcatac 256081 accggaattg atcgcttacc ccatgttaaa aggaacgccg gctgctggaa ttgacttgga 256141 acaaaagcaa tatgtatgga atatggatca tcagccgccg tcagacgact ttgtccgcac 256201 acttgccgac atactggctg aattacatgg cacggatcaa atatctgctg ggcaatccgg 256261 aatagaagtg ataaggccag aagatttcag gcaaatgaca gcagactcta tggttgatgt 256321 gaagaataag cttggcgtat ctacgacgct ttgggaaaga tggcaaaagt gggtagatga 256381 tgatgcatac tggccgggtt tctcttcttt gatacacggc gatctccacc cgccgcatat 256441 ccttatcgat caaaatggac gtgtcacagg acttctggat tggacagaag cgaaggttgc 256501 tgacccagcc aaggattttg ttctttatca aaccattttc ggagaaaaag aaactgcccg 256561 tttgcttgaa tactatgatc aagcaggcgg ccgaatatgg gcaaaaatgc aggaacacat 256621 ctcagagatg caggcggcgt atccggtgga aatcgccaag ctagctctgc aaacacagca 256681 ggaggaacac atcaatatgg cgctggaagc acttggtgta acatcggatt aagaattgac 256741 ttcgtttcat gaaccgagta ttataaactc tacaaataat agaacggatt aacaatcgtg 256801 aggaagagca agtacgcatc agaatggagg ttcagagagt cggtggcagg tgtgaaccga 256861 tcctcccctg atgccgaatg ggcttctgaa ttgctttgct gaacggatag taggcgatgc 256921 cgggtttctc tccccgttac caagagagga gtatcgaaac ataggttttc tgtacttaga 256981 gtgaacggct gtatagctgt taataaaggt ggtaccgcga gaccctcgtc ctttgcatag 257041 gacgggggtt ttttgtgttt cttaaaggag gtgacggcca atgtacgatg gctggtggtg 257101 gcatagcaga tgagttagaa aggaggatat caaatggtca ttgcaactga tgatcttgag 257161 gtcgcatgtc ctaaatgtga aagagcggga gaaatcgaag gaacaccttg cccggcctgc 257221 agcggaaaag gtgttattct gactgctcaa ggatatacgc ttctcgattt tatccaaaag 257281 catttgaata agtaaaggag aaaagctgag ctgagatgag agcagaagag cagagtaaga 257341 ttcgtgaggc cgcagcaggt acgatttttt tgctgatcgg aacagtttgt tttgcgtcta 257401 aatcgatttg gataaaatgg gcataccaaa tgggtgctga gccagatgcc gtgctgctat 257461 acaggcagct gctggctgtt ccgctgtttt ggctgatttt tttaatatac cgtcctccaa 257521 tgccagacgg taagaaaaaa ggagacctat ggaaggcttg tggcgcggga gtgttttgtt 257581 tttttctgtc tcccttgctt gattttatcg ggctgaacca tgtatccgca atggttgaac 257641 gtatattgct gatgagctat ccgttgtttg tgtttggatt caccgcgtgt cgtgaccgga 257701 aaatgtcctc aattcaggac cttttcgcag ttctggcggt catgtttggg cttttcttgg 257761 cgctgggcgg ctggaatgct gagcttttcc aggcgaatat gattggagct gtattcattt 257821 tgttatcttc ggccgtctat gctggttatc ttgtcctttc cgggcatctc gtccatcaaa 257881 tcggagggat ccgtctcaat gcatacggga tgacagctgc tggagctgcc atgatgcttt 257941 acacagggat aaaatcggcg gctggcatga atacgccaat ggcagcatat ccgctttcta 258001 tgtatggttt gttcgcagta attgcagtcg ttaccacagt gattccattt gtgctaatgc 258061 ttgagggcat aaaacgaatc ggggcacagc gagccgccgc catttcaatg gcagggccta 258121 tcctgacgat tttctatgga gctttatttc tcggtgaacg gctcgggctc attcaagtca 258181 ttggatgcgg tggcgtattt tttgtcatta cgggcatgga atacaggaag ctgaaaacag 258241 gaaaaaaaga ataattttta taaaacacac acgtttttca attacaataa gtgtaattac 258301 gtgtgtgttt tttgattttg taaaggttag gtgaggagat gcagcgcata ttgcttgtag 258361 aagacgacca ctcaatcagt gaaatggtgg atcattattt aacaaaagaa ggctttggaa 258421 ttgtgcatgc tttcgacgga gaagagggca tccggctgtt tcagcagggt tcatacgatt 258481 tggtcctcct tgatatcatg ctcccgaagc tgaacggcat ggattttctg aaaatcatcc 258541 gggaaaaaag caatataccg gtcttaatga tttcggcaaa agatggagat gtggacaagg 258601 cattgggact gggctttggg gcggatgatt atatcgccaa accgttttcg atgattgagc 258661 tgacagcccg agtaaaagcc gcgatacggc gggcgacgca atattcggca gaggagccgg 258721 ctgtgaataa ggtgatccgg attcaccagc ttgcgataga tatagacaat gtttccgttt 258781 tgaaaaacgg agagccgctc cagctgacgt caacagaatg gcagctgctg tgcttatttg 258841 catcaaatcc taaaaaagtg tttacgaaag aacaaatcta ccgttccgtt tggaatgaag 258901 agtactttga tgatcagaac atcattaacg tacatatgcg gcggctcaga gaaaagattg 258961 aggatgaccc ctcctcccct caatatatta aaacgttatg gggcatcggt tataaattag 259021 gagagtttta gaatgacagt gctatgggtg gccgctgtca tcgctctggc gtgtctgaat 259081 gtgattcaat tcataatgaa aaagaagcgg gacgggaatc tggcttacac ggctgaccag 259141 cttagctaca tgctcagccg ggattcggca ggacaaattt tgcttcctac agacgatcat 259201 gcgctcaaag acttgcttgt taacatcaat cttatcgttg agaatcgtca gcagatcagc 259261 gcccaatttg ccaaaacaga gcaatccatg aagcggatgc tgaccaatat gtcgcacgac 259321 ctgaaaacgc cgttaacggt cattctcggt tatattgaag ccattcaaag tgacccgaac 259381 atgccggacg aagagcggga aagattgctg gggaagctcc gccagaaaac aaatgaactt 259441 attcagatga tcaattcctt ttttgattta gcgaaattag aatctgaaga taaagagatc 259501 ccgatcacca aagtacatat gaacgacata tgcaaacgaa atatcctgca ctattatgac 259561 gctgttcagt caaaaggctt tcaagcagcc atcgatatcc ccgatacgcc ggtgtatgcg 259621 caggcgaatg aagaggctct ggacagaatc ctgcaaaacc tattgtccaa tgcgattcaa 259681 tatggcgcgg ccggcaagtt aatcgggctg acgctgtctt atgatgagag gaacatcgcc 259741 atcaccgtat gggatcgcgg aaaagggatt agtgaaaccg atcagcagcg ggtgtttgag 259801 aggctgtaca cactggaaga atccagaaat aaagcatttc aaggaagcgg cttgggttta 259861 accatcacaa aacggcttac agaaaaaatg ggaggcatca tatccgtcca aagcaagccg 259921 tacgaacgga ctgcatttac gatcacattg aaacgcatga catattaatc gtaagaattt 259981 cttaaggttt gagaaataaa aatgacaggg ctcgccgcta caatagaaaa caggaaaaga 260041 gagggaagga gaaacaaagt tgacttatat cgtacaaaca aacgggctga ccaaaacata 260101 tcagggcaaa gaggtcgtat ccaatgtcag catgcatatt aaaaaaggtg aaatctatgg 260161 ctttctcggc ccgaacggcg cggggaaaac aaccattatg aaaatgctga cgagccttgt 260221 caaaccgaca agcggtgaaa tcatcatcct tgggaacaag ttcacccaca cgtcatatga 260281 ggtgctgggg aacatcggca gcatgattga atatccgatt ttttatgaaa acctgacagc 260341 tgaagaaaat ttagatctgc attgtgaata tatgggatac cacaataaaa aagccataca 260401 agaagtgctg gatatggtga atttaaaaca aatcgacaaa aaacccgtca aaaccttttc 260461 cctcgggatg aagcagcgcc ttggaattgc gcgtgccatc ctcacgaagc cggacctgct 260521 tattctggat gagccggtga atggtcttga ccctctcggc attaaaaaga tcaggcaatt 260581 gtttcaagtg ctgagcaaag agtacgggat gacgctgctg atctcaagcc acctgctggg 260641 tgaaatcgaa caaatcgcgg acacaatcgg cgtcattcgg gacggcaggc tgcttgaaga 260701 ggtatcaatg gaggatgtca ggggccagaa cactgaatac atcgagcttg tcacgccgaa 260761 tcagacaagg gcctgctttg tgctggagaa agagctgcaa ttaaccaact ttaaaatatt 260821 aaatgagaaa acgattcgaa tttacgaggc tgaagcctct caggctgcca tatccaaagc 260881 attgatttta aatgatgtag acattgaatc aatgaacaaa aagtatacgt cgctggagga 260941 ttattttatc aaattgatca acggcaatag catcagtgcg taaaggagga gagacacgtt 261001 gatgaatttg atcagaatcg aattaagaaa aatgaaaatg ggctggtata tcagaggtgc 261061 cctcattgcc aacgtgatca ttatgggttt tatgtggctg atcagttatt ccgaaaaagc 261121 cgatggcggg gtttcgttcc aaagtacgga tgaagcattc ctcatcatcg gcaccttcgt 261181 cagagcggta tttatcgtat ttggcgctgt gctgatcgta aaattggtga tttcggaata 261241 taaaaacaaa accattcttg tgatgttcac gtacccgatc agccgtaaaa agctgctcac 261301 cgctaagctc atgatcgcgg gcggactgac gtttatcacg attttacttt caaatatact 261361 catagccgcc ggtttctttt ggctgaactc gatctgccat ttcataccgg gagagcttac 261421 ttccgagatc atttctcaac aggcggtcaa aatggcggtt ttcgcttttg gcgccgctgg 261481 aaccagttta gttcccatct tttttgggat gcgtagacac tcggttccgg cgaccatcat 261541 ttcatctgta gtaattgtga tgctcatcag ctcaacaagt ccgggcttct cgatttcatc 261601 tgttgtgtat atcccgttat cgttagcggc attcggtttg ttcttttcct acatggcgat 261661 caggaatgcg gacaagcagg atgcgtaaac aaaggcgccc aatatgtata aaaggccgat 261721 gctgtcagca ccggcctttc cattatgagt ctgttcttgt ttcaagataa tgcttcttgc 261781 caatctcttt gctcatcata tagaaatgga agcaatattc accgattgcc atgacgatcg 261841 cgccgaataa agccgccaat gcaacttcac cgccagtcat ccccatagaa agcggcatgc 261901 ccatcagcca gatcacgaga aaggccaaac caaaatcagc caaagttgca atcatattat 261961 tccatttcgg caatacataa agatcgccca gcaaataaga aataacccct aacacaatcg 262021 tcattagcag cgtatcacca aacgtgaaac caaagcccag accaagcacc agatacaaca 262081 caataatcgt cataatacct ttaatagcga gcgctttcac atgtgtcatt acaattcctc 262141 cttttgtcat ttgatttgtt atgtataatt cctcaaatgt aaaaagttaa accttatttc 262201 ttttcggagg cgggtgcaaa tctgctgggg agaggtcaat gatgtgaatc caggaattga 262261 ggctgcggcg cttcgacagc ggaaacgtga agcttgtact gcaccggacg ctgctttgat 262321 gcccaacagc ccattatgtt tgctgttttt agatgaataa atttaaaaac ttctcctgtc 262381 cctccgtcat cacttctgaa gtaatgaaat atgatgaaaa gagatcaagg ggaggtgacg 262441 tgatggcggt cgtgagagca acgagtgcgg atgtcgattt gatggcaagg ctgctcagag 262501 cggaagcgga aggcgaaggc aagcagggga tgctgcttgt cggcaacgtt ggaattaatc 262561 ggctgcgggc gaattgctca gattttaaag gcctccgcac catcaggcag atgatttatc 262621 agccacacgc gtttgaggct gtgactcatg gatattttta tcaaagggcg cgagatagcg 262681 agcgtgccct tgcacgccgg tcgattaatg gtgaaaggcg ctggcctgca aaatttagtt 262741 tatggtactt caggccgcag ggggactgtc cagcccagtg gtataaccag ccgtttgtgg 262801 ccagatttaa gtcacactgc ttttatcagc cgacggcgga gacgtgtgaa aatgtatata 262861 acacatttta gagacaggac accgttcaaa ttgaacggtg tttttctttg aaaagatgca 262921 atgcaaaata ttcctgtgag ataatcaaag aaaaaagagc tgacggagat gacagaatgg 262981 caacaattga cctgcaaaag aaaagtgtaa agatcgtact ggagaaaaag cagttaacga 263041 aggtgacggc tcgtgttgga ctggttcttg atattacggg atcgatgaga ccgctctaca 263101 aaaacgggac ggttcaaaat gtggtggagc ggattttggc agtggctgat cagtttgatg 263161 ataacggttt gctggatgta tgggtgtatg ataatgaatt ttcccgatta aagccagttt 263221 cagaaaagga tttttcgggc tatgtcgatc gtgaaatttt aaataatgac cgcttgcata 263281 aattcggcag aaatgatgag ccgccagtca tgaaggacgt gctgcgcaaa tatgttacgg 263341 aggaaccgag ctcgtatcct gctttcattg tttttatcaa tgacgggggc tgtaaaaagt 263401 caatcaaacc gataattgaa gcttcttctg ataaaccggt gttctggcag tttgtcggca 263461 tcggaaacgg aaactttgat tttctcaata aactggatac gttagaaggg cgtgtcattg 263521 ataacacgaa cttcctgcat atcgaagaga ttgaccgcat ttctgatgat gagctttatg 263581 atgctctgct tgctgaattt ccattttggc tgaaagaagc gaaggaaaaa gggattgtaa 263641 gagaacaaga gcctcctgct gaaaagccga aaaagaaggg ctttttcagc agattgtttt 263701 cgaaataact gataaagagc actgagtcat tctgcgaaat ggctcggtgt ttttgttttt 263761 ttaagatcat gtgaagaaaa ataggccgaa tgggcggctt gcaaacgaca ggatatgcag 263821 aaaacgcgtc attcagccag ctttcggcat gtttcagcag caggcttgtg agggaagacc 263881 tgtttttaat gttcagcgct tacaatcagt tcacacttct tcacagtcgt ttaacaatga 263941 tttcctataa tggagacgat caatgaggag agaggggatc ttgaatggca tacgacagtc 264001 gttttgatga atgggtacag aaactgaaag aggaaagctt tcaaaacaat acgtttgacc 264061 gccgcaaatt tattcaagga gcggggaaga ttgcaggact ttctcttgga ttaacgattg 264121 cccagtcggt tggggccttt gaagtaaatg ctgcgcctaa cttctcaagc tatccgttta 264181 cattaggggt agcgtcaggt gatccgcttt ctgacagtgt cgtgctttgg acacgtctgg 264241 caccagatcc gctgaatggc gggggaatgc cgaagcaagc agtgcctgtc aaatgggagg 264301 tcgcaaagga tgagcatttc cgcaaaatcg taagaaaagg cactgaaatg gctaaaccaa 264361 gtcttgccca ttccgttcat gtggaagcgg acgggcttga gccaaacaaa gtgtactatt 264421 accgtttcaa aaccggccat gaactaagcc ctgtcggaaa aacaaaaaca ctgcctgccc 264481 ctggcgccaa tgtgccgcaa atgacctttg catttgcttc ctgccagcaa tatgagcacg 264541 gatattatac ggcctacaag catatggcaa aggaaaagct tgatcttgtc ttccatctcg 264601 gtgattacat atatgaatac ggcccaaatg aatatgtatc aaaaacaggc aatgtccgca 264661 cgcacaacag cgcggaaatc attacgctgc aagactatcg gaaccgtcac gctcaatacc 264721 gttctgacgc caatcttaaa gctgcacatg cggcattccc ttgggttgta acttgggatg 264781 accatgaagt tgaaaacaac tatgccaata aaatacctga aaaaggacag tcggttgaag 264841 cattcgtgct ccgccgcgcg gcagcatacc aggcatacta tgaacatatg ccgctccgca 264901 tttcctcttt gccgaatggc ccagatatgc agctgtaccg gcactttacg tacggaaacc 264961 tggcgtcctt caatgtgctt gatacccgcc agtacaggga cgaccaagcc aataacgacg 265021 gcaataagcc gccttctgat gaatcgcgca atccgaatcg gactctgctt ggaaaagaac 265081 aggagcagtg gctcttcaac aatttgggca gctcgacagc ccactggaat gtgctggcgc 265141 agcagatttt ctttgccaag tggaatttcg ggacaagcgc aagcccgatc tacagcatgg 265201 attcgtggga cggctacccg gctcagcgcg aacgggttat caatttcatt aaaagcaaaa 265261 atctgaataa tgttgtcgta ctgacaggtg atgtacacgc aagctgggca tcgaatttgc 265321 atgtcgattt cgagaagaca agttcaaaaa tattcggagc cgaatttgtt ggaacctcga 265381 tcacttccgg agggaacgga gcggataagc gagcggatac ggaccaaatt ttaaaagaaa 265441 atccgcacat ccagttcttt aacgactatc gcggatatgt ccgctgtaca gtgacgcctc 265501 accagtggaa agccgattat cgggtgatgc catttgtgac cgagccgggc gcagccattt 265561 ccacgcgggc ttcattcgtt taccagaaag accaaaccgg gttgagaaag gtatcatcca 265621 caacaatcca aggcggggtg aagcaatccg atgaggtcga agaggatcgt ttcttttcgc 265681 acaacaaagc ccacgaaaaa caaatgatta agaagcgtgc aaaaatcacg aattaaggag 265741 tggaaattat gttttcaaac attggaatac cgggcttgat tctcatcttc gtcatcgccc 265801 tcattatttt tggcccttcc aagctgccgg aaatcgggcg tgccgccgga cggacactgc 265861 tggaatttaa aagcgccaca aaatcacttg tgtctggtga tgaaaaagaa gagaaatcag 265921 ctgagctgac agcggtaaag caggacaaaa acgcgggctg aatgctgatg aggcagacac 265981 cgggtctgcc tcttttttta tgaaagggag ggcttttttg aatggataaa aaagaaaccc 266041 atctgatcgg gcatttagaa gagcttcgcc gccggattat cgtcaccctt gcggcatttt 266101 ttctatttct catcacggct tttttgttcg tacaggacat ttatgactgg ctgatcaggg 266161 atttggatgg aaagctggct gtgctaggac cgagtgaaat cctctgggtg tatatgatgc 266221 tttccggcat ttgtgccatt gcggcttcta tccctgttgc cgcgtaccag ctgtggcgtt 266281 tcgttgcacc ggcgctgact aaaacggagc gcaaggtgac gctcatgtac ataccaggtt 266341 tatttgcgtt gtttttggcg ggcatctcct tcggatactt tgtcttgttt ccgatcgtgc 266401 tcagcttttt gactcattta tcctccggcc actttgaaac gatgtttacg gctgaccgct 266461 actttaggtt tatggtgaat ttgagcctgc cgttcggctt cttgtttgag atgcccttgg 266521 tggtgatgtt tttaacaagg ctgggcatct taaatcctta cagactggcc aaagcgagaa 266581 agctttccta ttttctgctg attgtcgtgt ccatattgat tacaccgcct gattttattt 266641 ctgattttct cgtgatgatc ccgcttcttg tcctgtttga agtgagtgtc accctatcgg 266701 cgtttgtcta caaaaagagg atgagggaag aaacagcggc ggccgcttag tgcagcgtac 266761 cacccggtga cttcacatcc tcatcatatt gtgcggccgt aacagcggcg attctcaatg 266821 cccggacaat cgtgtccagg ctgaggctcg gcgctgtttt gtcgattgtt tgctgcggaa 266881 tgtaaggaat atgaataaaa ccgccgcgaa tgtgtgggga tgtccggcta atgtgatcca 266941 ttaacccgta gaacaaatag ttgcatacaa aggtccccgc tgtgtaggaa accgcagctg 267001 gaatgccgtg ttccttcatc ttagcagtca ttcgtttcac gggaagcctt gtccagtaag 267061 cggcgggccc atctggagaa atctcttcat caatcggctg atgtccttcg ttatcgggga 267121 ttcgcgcatc tgcaaggttg attgccactc gttccggtgt aatctgcatc cgtcctcctg 267181 cttggccgac acaaattacg atatctggct gatgtttttg aatggcttgg cgcagagtgt 267241 ccagagcgga tctaaagacg gttggaattt gttccgctgt aataatggct tcttctgtct 267301 cgaagccatt aagccgtttc gccgcttccc atgatggatt gacggtttct ttgtcaaaag 267361 ggtcaaagcc tgtgatcagc actttttttc tcattctccc atctcctttt tcttttattc 267421 tattgtttat ttatgggttt ttcatcaaaa taatgtaaag gagtgaatca taatggagca 267481 tttgccggag cagtatcgcc agttattccc aaccttgcag acgcatacga tgcttgccag 267541 ctgttctcag agcgcattgg cagagcctgt atcaagggcg atccaggatt attatgatag 267601 cctgctgtat aaagggacga actggaaaga agcgattgaa aaaacagagt ttgcgagaaa 267661 cgagtttgca aagctgatcg gggctgaacc ggatgaagtg gcgattgtgc cgtcagtttc 267721 tgatgcactg gtttctgtag catcgtcctt aactgcattt ggaaagaagc acgttgtata 267781 tacagatatg gattttccgg cggtgcctca tgtttggcag gcacactccg attataccgt 267841 atccgtcatt ccatcaatag acggcgtgct gccgcttgaa caatatgaaa cgcatatttc 267901 ggatgaaaca gtactgacgt gtgttcctca cgttcattat cgtgacggct atgttcagga 267961 tataaaagcg attgccgaga tttctcagag aaagggctct ttattgtttg tagatgctta 268021 tcaatcagcc gggcatattc ccattgatgt gaaggaatgg ggcgtagata tgctggcagc 268081 aggcacccgg aagtatttgc tcggcatacc gggtgtggcg tttctttatg tgagaaagga 268141 gctggctgac gcactgaagc cgaaagcatc agcttggttc ggaagagaga gcggatttga 268201 tggggcttat gcaaaagtcg cgcgccgttt tcaaacgggc accccagctt ttatcagcgt 268261 atacgcagct gcagcggctt tatcgctgct gaatcatatt ggggtttctc atatcaggga 268321 tcatgtgaaa acgatctgtg ccgatgcagt tcaatatgcc gctgaaaaag gcctgcagct 268381 ggcggcggca caaggtggga ttcagccggg catggttgcg atccgggatg agcgggcatc 268441 ggaaacggcg gggttgctga agaagaaaaa agtgatttgc gcgccgcggg aaaatgttat 268501 ccgtctcgct ccccattttt ataatacgaa ggaggaaatg cggcacgcga ttgatgaaat 268561 cgcggcgaaa acgatccaca agtaaacatg aaaaagcccc tgaacactag tcaggggctt 268621 ttcatattaa tgatctactt taacgcgttt cataaagaaa gcgccaatta aaccgataat 268681 ggcaacaatc attgcaaaca caaatgcgtg ctgtacgcct gctgtcaaag cttgcgggat 268741 gactgccgga tcggcagggt ttttaactgt actcatataa tcatgctggc ctgcagccat 268801 aatgctgacc gcaaccgctg ttccgatagc gccggccatt tgctgcagcg tgttcataat 268861 ggcggtgccg tctggataaa attcacgcgg cagttggttt aaaccgtttg tctgtgcagg 268921 catcatgatc atagaaatcc cgatcatcaa gcaggtgtgc aggatgataa tcagcacagc 268981 tgttgaagtg gtcgtgacat ttgagaagaa ccatagtaca acggtgacaa tcacaaatcc 269041 cggaatgaca agccatttcg gcccgtattt atcgaacaag cggcctgtaa caggggacat 269101 aaatccattt aaaataccgc ccggcaagag aacaagacca gatgcaaatg cagtgaggac 269161 taagccgcct tgcagataca tcggcagaag cagcatagat gacagaatga ccatcataca 269221 aatgaacacc atgatcacac ccaaaataaa catcgggtat ttgaacgcac ggaggttcat 269281 cataggctgc ttcattgtca gctggcggat tgaaaataag ataaggccga caacgccgac 269341 aatcagcgac acgataacag tcgggctgga ccatcccccg gagccttcac ccgcgttgct 269401 gaatccgaat acaatgccgc cgaagccaat cgtcgacagg atgatagaca atacatcgat 269461 tttcggcttt gtcgtttcag atacattttg catatatgcg ataccgaaaa caagcgccag 269521 cacaaggaat ggaagagaga tccagaaaat ccagtgccag ttgagatgct ccagaaccaa 269581 tcctgagaaa gttgggccga tggcgggcgc gaacataatg acaagcccga tcgttcccat 269641 tgcggcaccc cgtttatgag gcgggaaaat caccaagatt gtgttaaaca tcagcggcag 269701 taaaagaccg gttccaagtg cctgaacgat ccttgccgct aataaaaacg agaagctcgg 269761 cgcaagcgcc gcaatgaatg tacctaaaat tgaaaagata agtgacacgg taaaaagctg 269821 tcttgttgtg aaccactgca acagcagtcc tgaaacagga acaaggatac cgagtacaag 269881 caggtagccc gtcgttaacc attggacggt tgccgctgta atgttcaatt ccttcataag 269941 gtcggttaac gcaatattca gcgctgtttc actgaacatg ccgataaaac cggccaacag 270001 caaggaaatc ataatcggca tcactttgta ttgctgagat gctttagctg ttgtttccaa 270061 aatcatttcc cctctctatc aactgcatgt agtatgtcgt tttttttatc tcttcagcag 270121 gtcaggaatg cagctggaga tatgaaggag cggcgtactg ttttttgccg tcaaagataa 270181 aaggatgccg ccttcaatca tcgcgttaac cacagtgctg gcttcttttg cacggctctc 270241 gctgcagcca gtctgccgca gtttttcctc atacacagag gcccattctt tgtaggcttc 270301 atgacaggct tcgcgcaacg gttcgctttt caatgacgtc tcagccgcta gcaagcccac 270361 aggcaagcct tcaatgtctt ccgtacatga aaactggcag gagagctcct tcaaaaaggc 270421 ttgaatgcct tccgctggat cggtgcaggc ttccatgcag tccgcgattt tctgacggat 270481 atactccttc atctcattca cggcttcgat cgcaagctgt tctttacccc cgggaaagtg 270541 gtagtaaaga gagcctttag gcgcgccgct ttcctttata atctggttca gccccgtgcc 270601 gtaataccct tgcagctgaa aaagccgggt agctgccgaa aggattttct cacgggaatc 270661 tccataactc ataacattcc caccttactg aattgcaatc aaaaatatag tgactggtct 270721 attatcttga ttcaatcatc aattgtcaag aaaaattcat tgtatgaaaa gacaaaaaaa 270781 gaaggatatg acaacaaaaa atactgagag aaaagctgac tgatcttttg actgaataga 270841 taaaatgtac aatgattaat catcatatgg atgtaaggag agaaatagat gaaaaaacaa 270901 cgaatgctcg tactttttac cgcactattg tttgttttta ccggatgttc acattctcct 270961 gaaacaaaag aatccccgaa agaaaaagct cagacacaaa aagtctcttc ggcttctgcc 271021 tctgaaaaaa aggatctgcc aaacattaga attttagcga caggaggcac gatagctggt 271081 gccgatcaat cgaaaacctc aacaactgaa tataaagcag gtgttgtcgg cgttgaatca 271141 ctgatcgagg cagttccaga aatgaaggac attgcaaacg tcagcggcga gcagattgtt 271201 aacgtcggca gcacaaatat tgataataaa atattgctga agctggcgaa acgcatcaac 271261 cacttgctcg cttcagatga tgtagacgga atcgtcgtga ctcatggaac agatacattg 271321 gaggaaaccg cttatttttt gaatcttacc gtgaaaagtg ataaaccggt tgttattgtc 271381 ggttcgatga gaccttccac agccatcagc gctgatgggc cttctaacct gtacaatgca 271441 gtgaaagtgg caggtgcccc tgaggcaaaa gggaaaggga cgcttgttgt tcttaacgac 271501 cggattgcct cagcccgata tgtcaccaaa acaaacacaa ctacaacaga tacatttaaa 271561 tcagaagaaa tgggcttcgt cggaacaatt gcagatgata tctattttaa taatgagatt 271621 acccgtaagc atacgaagga cacggatttc tcggtttcta atcttgatga gctgccgcag 271681 gttgacatta tctatggata ccaaaatgac ggaagctacc tgtttgacgc tgctgtaaaa 271741 gccggagcaa aggggattgt atttgccggt tctgggaacg ggtctttatc tgatgcagcc 271801 gaaaaagggg cggacagcgc agtcaaaaaa ggcgttacag tggtgcgctc tacccgcacg 271861 ggaaatggtg tcgtcacacc aaaccaagac tatgcggaaa aggacttgct ggcatcgaac 271921 tctttaaacc cccaaaaagc acggatgttg ctgatgcttg cgcttaccaa aacaaatgat 271981 cctcaaaaaa tccaagctta tttcaatgag tattgaagaa aagaaggcga ataagccttc 272041 ttttttttgg ctttttagga ccaataatga cctctgaatc ttaaaatttc tttaaaaata 272101 agccaaaatt accctttact taattaattt ggtaacgtaa tataattgga gaatttgtta 272161 caaaaaaagg aggatattat gaaatttgta aaaagaagga tcattgcact tgtaacaatt 272221 ttgatgctgt ctgttacatc gctgtttgcg ttgcagccgt cagcaaaagc cgctgaacac 272281 aatccagtcg ttatggttca cggtattgga ggggcatcat tcaattttgc gggaattaag 272341 agctatctcg tatctcaggg ctggtcgcgg gacaagctgt atgcagttga tttttgggac 272401 aagacaggca caaattataa caatggaccg gtattatcac gatttgtgca aaaggtttta 272461 gatgaaacgg gtgcgaaaaa agtggatatt gtcgctcaca gcatgggggg cgcgaacaca 272521 ctttactaca taaaaaatct ggacggcgga aataaagttg caaacgtcgt gacgcttggc 272581 ggcgcgaacc gtttgacgac aggcaaggcg cttccgggaa cagatccaaa tcaaaagatt 272641 ttatacacat ccatttacag cagtgccgat atgattgtca tgaattactt atcaagatta 272701 gatggtgcta gaaacgttca aatccatggc gttggacaca tcggccttct gtacagcagc 272761 caagtcaaca gcctgattaa agaagggctg aacggcgggg gccagaatac gaattaatga 272821 aaaacaaaac cttgaagaat gctattcttc aaggttattc tgctttcagc acaatggttt 272881 tcgcagccat atcatgaacg gtttgttttt tcttcgtaaa tgcggcagtc aaatagatca 272941 ggcgggagaa cacatgcacc cacgctatca ggtaacggac aatggcttgc gggaaggata 273001 tttttttata tgtttcgtcc ctcacgattt gcagcccgat gatttttttg cctagtgtgc 273061 ccttccaatt tgtcagcggc atcagcaaag ggtacacaat cagcatcaat atggcgacaa 273121 taatgacacc ggcggaccca tcgccaaacg taaatccggc tgccaaaatc actgctgcgg 273181 caatgattac atcaagtaaa agagcgcagg cgcgcagcat gaaaccagct agttccaata 273241 gaaacactcc ttaaaatgtt aaataaacac ctaatgattg taaaaaagaa gggcctaaag 273301 tgggaatagg tgataagcct taaatcacaa aagttggtga aaatgtcata ggtaaattgg 273361 cataatcagc cagcttatca cattaccaaa ttctttttta gcccgaaacc aagccctcag 273421 aagttatttt tgttaaaata gaaaagttac aacagaattc ggagggttta ttgtgggaaa 273481 agtgaaacga aatgcccctt gcccatgcgg cagcggcaag aaatataaaa aatgctgcgg 273541 aagtaaagtt gtcgacttcc cggcggaact agcggcaaaa gaagcgaaac aaattcagga 273601 agacttagtg gagtatgcct tcacagtaca tagagaaagc atttcaggct ttatcaacca 273661 gcatgatttt ctttctgcta tggacagaca gacgaaagac atcagcgtat ttaacttagg 273721 aatctgggga atcttcttcc acccgcttgc tggtgagaag acaatcttcg aagagtacct 273781 tcagaaaaaa ggcgattcga tcactcgtcc gaaaacgcgt gagatcgtag aatcatggca 273841 gagcatgacg cctgctttat tgctgctgaa ggacctgaag gaaggcatca ttcactttga 273901 agatgtcatt acggcaaaac aattcgaagt ggaaatggac gccagcaatc aagaccttcc 273961 tccagtggga agcctgattc ttggataccc aatccacgaa gcggaaaaag cagaattctt 274021 catgcagttc acgatcttcc cggtgaagag aacagaagcg ctgatcagca aggtgaagaa 274081 atatgcggat gccgctgtga aggacggcaa aacgccggag gacttcatga agcaggaatt 274141 caacaacgtt ctgttcgcgt tgttagctga gaaagatgaa gagccacaag cagagaaagc 274201 ggaagtaagc actgttgagt gggcaaacga cttggagaaa gaaaccgctg cggctattga 274261 agaaggcatg agcggggaag agtatccgac tgaattgatc ccagctgtta ttgacatctg 274321 gaaaacattc tgcgagaaaa aatcacctgt catcagaaag ccggaagctt ttgcggcggc 274381 agttgaatat tatgtaaacg caatttctct taacggcgcg tccgtttccc aggctaaact 274441 ggcgaaaaaa tacggcgtta gcgcatcaac gatttccagc cgttacaaag aaattgaaag 274501 cacgctgcaa gatgaagcag atcgttttgc acaagcgtta tcctcataat ggaaaaaacc 274561 ttgaaaagcc aggcttttca aggttttttt atttctgaaa cggaattttg atttctaacc 274621 ggaagatggg gtggcggtag gtaaaatcca gcctgccaaa agcgcccttc accagttttt 274681 gaatgatata tgtgcccatg ccttcatgag cgccgttttt cgttgagcgg ccaaacgatt 274741 gataaattgt atcgagcact tttgggtcca tcccgggagt gctgttttca caagtcagta 274801 cataaagccc gctgcgcagt gaagtctcca gtttaatctc tgctttttct cgggcctccg 274861 ccgcgctgtc gagcgcattt tctaatatgt tgccgaccaa gctgacctga tcagcaggcg 274921 aaaacggaag ggaagaaagc ggtgtatgca tatgcagcga aacactcaca ttcgaggcgc 274981 gggctttttc taaaaaatca taaagcaccc ctgcaacgta cgcgttctct cctttcaaaa 275041 aacggtcata ttggctgtat tgatccgccc agttttgaat atatgcttgt gtatctgcct 275101 tgggctgagc tgatttgatt gcagtgatat gtttcattgt gtcatgattc cggcttctga 275161 catcaatcag catttgattg gcgtgctgtt cagcttgagt cagcttatca atttgatcag 275221 aaagccttgc ctgcaaagca gactgtccga tacggagccc ttcacaccct gcaaatatcg 275281 cgattacaca taataccggc atgatgtctg tgccaatcaa caccactccc accgacatca 275341 cttgaatcac cgcaatccac gcacaaagcc ctgaggaaca gtgtttccac acccgcttcg 275401 tattccaaat gtacaatcct gcagcagctg cgcctaaagc agcggcgagc caagaggcgg 275461 ctgtgctgtg tgaaaaagca gcagctccct gataacatat gaaactaaat aaaatcagat 275521 aaagacattg aaaaagggta atcacgtact aaactcctca aaaatagtag ttttgaaaat 275581 aatcaagctg ctgcttagtg atcatcgctt ttttagacgt tccctcaaag gaaactgtga 275641 atgaatgctt ggtataagcg gaaaaatgct ttatgtaatg aatgttgata ataaaggaac 275701 gatgcgaacg aagaaaatct ttttcgggca ggtcgccttt aatatcattt aatgtttgat 275761 acgtttgcac ctcttcggcg gttgtcacaa tcgtcgtcga acgtcccgtc cgttctgcga 275821 aaataatatc cttcttttgc aggacgtgca tttcagactt ttgctttatc aatatacgcc 275881 cattcaaact cgtttccgtt ttctttttca agtaccggtc gaaggaagcg gccagacggt 275941 cggcatagta cggcttcata atataatcat ggacgttcag gtcaaaggcg tgaaccgcat 276001 aaccgccgtg gccggtaaca aaaatcacat ccacatcaag tgaatgggat ttgatcaaat 276061 cagcaagctc gtagccagac atatggggca tctcgatatc ggcaagcagc agatcaatgt 276121 ctccgttctt tacccgcctg taggcttcct tcgctgaatc ggtggaaaag acaatttcga 276181 cgtcctgcat tctggacacg atcgcttcta acttctctaa atctactcga taatcatcta 276241 caagtccgac ttttaccatt atcattcccc tagttacata gaatcatctt tattctatcc 276301 catttcacga cataaaaaga actcttcgcg acaactttat ccaactaatc cagcttttcg 276361 tatatagtca ttactagaaa taaagataag ggagattgtg acatgattac actgaccgat 276421 tgcagccgca ggtttcagga taagaaaaaa gtagtcaaag cggtgcgaga tgtaagctta 276481 acaattgaaa aaggagaagt cgtcggcatt ctcggagaaa acggtgccgg caaaacgacg 276541 atgctgagaa tgattgcttc cttgcttgaa ccatcacagg gtgtaatcac agtagacggc 276601 tttgacacgg tcaagcagcc ggctgaggtc aaacaaagaa tcggtgtctt attcggagga 276661 gaaaccgggc tttacgacag gatgaccgct aaagaaaatc tccaatactt cggcaggctg 276721 tatgggctga accgccacga gatcaaagca agaatagaag atttatcgaa acggttcggc 276781 atgcgcgatt atatgaaccg gagagtgggc gggttttcga aaggcatgag gcagaaagtc 276841 gccattgcca gagcgctgat tcacgatccg gacatcattt tatttgatga gccgacaact 276901 gggcttgata ttacgtcaag caacatcttc cgcgaattta tacagcagct gaaaagagaa 276961 caaaaaacga ttcttttctc cagccacatt atggaggaag tgcaggcgct ctgtgacagt 277021 gtcatcatga ttcacagcgg agaggtgatt taccgagggg cgcttgaatc actatacgag 277081 agcgagcgca gtgaggattt gaattacatc tttatgtcta agcttgtcag ggggatttct 277141 taaatgctga gccatattta taaaaaagaa atgatcgacg ctttacgcga cagaaaaacg 277201 atattactca caatcttagt gccgatgatt atgatgcttg gacttgtctt tttttatgaa 277261 agcatgctgt ccgacaaagg ggagcagtac acgctggctg tcggccattc gcttccgccc 277321 gcactggaaa gcaagcttaa tgagattgac gaaatcagcg taaaaacatt tgcaaagcct 277381 gaagaggcag ttgatgaagg aaaagcagat gcctatctga acgtcccgaa agagttcgac 277441 tcatatgtca acagcatgac accttttaag gttgatgttt acggcaattc aatcgatcaa 277501 gggtcgtcaa atgccatgca gcttgtgcag tctgccttag atcagtacaa aaatgaaatt 277561 gtgcagcaac gtttaacaaa taagcatatt gatcaatcgg tgatccagcc gtttacaatt 277621 cagcaaaagg aagcggatga ggagaaaggg acttccgcta ttatgctttc cgccattctg 277681 cccatgctga ttctgacttc cattgtttcc ggcgcaatgc cgatcgctct tgatatcatg 277741 gccggtgaaa aggaccgaaa gtcaatcgag gcgctgctat taacgccagt cagcagaaac 277801 aaagtgctgg tcggcaagtg gcttgcggtt tccacttttg gcgtggcttc aggtgtattt 277861 gctttggtgt ttttgatttt gtccaccgtg ttatttaccg aaaatttaaa aacggccttc 277921 cagctgggag atcatatgtg gagtgtaatc ggcgcttcag ccttaatcat tgtgctctct 277981 gcattgctga tatctgcgat ggagcttttc atcagcatca tgtccagctc ggtaaaagaa 278041 gcgcaaagtt atatgtctct cgtcgtcttt ctgcctgtgt tcccgatgtt tttcatcttc 278101 agcaaggcac cgaaccaatt tgacttatca tactttctca tcccgtttct gaacctgcat 278161 gcgttattta aacagctttt attcgggatg gttgacccgg ctaccatttt gtctacgtca 278221 ggaaccatcg ccgtgctcat cgccatcttc tttttactag ccagagcctg cttcctgaaa 278281 gacaaatggg ttcttccaaa ataaacttgc gaaaggagaa atacactttc tcctttttgt 278341 atatcctgaa aaaagaagga aaatagaaaa aggatatcta atacaaaaag tgaccctgca 278401 ctatttttca tcaaaattgg tttcaaagga gaaggaacaa tggatcaaac acgtacactc 278461 ggcaaaacga agctgaaggt gaagcggatc ggattcggcg cgaatgcggt cggcgggcat 278521 aatctatttc caaatctaaa tgatgaaaca gggaaggatt tagtgcgcac ggcattggat 278581 ggcggcgtca attttatcga taccgccttt atatatggat tggggcgatc tgaagaatta 278641 atcggcgaag tcgtacagga acgcggcgtg cggaatgagc tcatcatcgc caccaaagga 278701 gctcataaag aagtggacgg cagcattgaa ttagacaata gccgggagtt tcttcgcagc 278761 gaggtggaga agagcctgaa gcggctgaaa acagattaca ttgatttgta ttatgttcac 278821 tttccggatg gaaaaacacc tctcgctgaa gtggcgggca ctttgaaaga gctgaaggat 278881 gaggggaaaa tcaaagcgat cggcgcttcg aacctcgatt atcagcaatt gcaggatttt 278941 aatgctgacg gctatttgga ggtcttccag gccgaatatt ctctcataca gcgtgatgcc 279001 gagaaagagc ttcttccata ctgtgaaaaa caaggcatct cctttattcc ttactttccg 279061 cttgcgtccg gactgctgac aggaaaattc acgcaagaca cagtctttga tgatttcaga 279121 aaggataaac ctcaatttca gggtgaaacg tttatccaca atctcaaaaa agtagataag 279181 ctgaaagcag tagcggagga aaaacaagcg gatacggcac atgtcgcctt ggcgtggctg 279241 ttaacgagac cggcgattga tgccattatt ccaggagcta aacgaccgga gcaattacag 279301 gataacctga aaaccttgaa cattgaactg accgaagatg aagtgaattt catcagcgac 279361 attttcaaat aaaaaaggaa atagccgtca tggctatttc cttttggtgt tttattcttt 279421 gatgaatgct tcgactaatt ctgctgctct gtaatcatcc atatcaagct gccattggtc 279481 gatgtcattt ttcttcattt tcacttcaac tgttttttca gatgaagcag gtccaagctt 279541 tttgaattcc tcaggataga cttgaagcgc gtatttcact gcctcttcat agctggcact 279601 agagttttta ctgtagtagt ctttcacttt gtcttcgatg cggtctgaaa gagaagatgc 279661 atctacaggt ttaactgtgg cttcaacaat tgcttcgtct ttagagattg aagtcgtttt 279721 tgcttgaatg gaagagtttt tgcttaatcc ctctttaatg ccgttcacga tattatcaag 279781 cgctttgctg tccgcatatg tgctggaaag gccggaagct gagagataac cgtctttggc 279841 tgattcatta aaatcattta caatttcatt tttgttagcg ccggtgattt tttcgaaatc 279901 ggcgttatct ttgccgaaaa gaaggacatc aacataagct gataacgctt ttgcagaatc 279961 ttggagctta tctgccgtcg ccaggatttt tttgtctttt ccgtcaattt taaaagtaac 280021 tgattttggc tttttatcac cgtaagattc cggcgtatag ttaagctcgt attgcttgcc 280081 tttatctaca acgaagaaaa gatttccttc aacggatttg tcagcgttaa tcgtgctgcc 280141 ctgaagcttt tcgctatagt cttcagggtc tgtgtcagac attttggtat caccttgata 280201 caatgtgaaa tccatactgt ctacattcag cgggtctttt cctgtgtttt tcaccgcgac 280261 attgactttt aacacaagct ggtcatctga agtggactta tcatatttag acggaagtgt 280321 gtaagagaca tccttgattt tgacttgagc tatatctgag cttttttctg tttctgattc 280381 tttcttctcc gcgcttgttt tgctgccgga acaagcagct gtaaacatca tcagcagaag 280441 aattaggaaa acagcgtacg tttttttctg aaacattcat ttttcctcct caaatggttt 280501 aggaaagggg agtcttttgt ctttgagaaa tggatctttt tgaatggatt agcatcatat 280561 aaccaaaaaa atcagttctt ttctcacggt tttcaccgga ttttctggaa actccgccct 280621 cctttgtcat gaatggacct ataaaaagtt acaacggaat taattttaag attattagct 280681 tttatattga ataggttcat catcctattt ttggtgaaaa atgttctggt aaaactggta 280741 aactcagaaa actgtgtatt ttagactatt actttttgat tagttggagg gaacttaaga 280801 aggatgaaag gggccgcctt tgtgaagaaa gagggactga aacaaaaagc actggaaatc 280861 ggccgggtgc cgacacactt aaaactggaa attgaagatt atggcggtga tgataaaaga 280921 gctcattttt gttgggcaga tcctcaggat gagaataccg gcattatcgt ggagcttgga 280981 ccggacggag agctggaatc cctttcccgt gatattgagc ctgaaagcgg agaaaggctg 281041 tctgaggaga aactagagga tatcatgcgc caatttgtcg agactcatca tccgggggca 281101 ctctctgcct ttgttcgtga agaaaatgac cgtgcatacg gcgataaagt gagattttca 281161 tatgttcaaa tggaggctgg gcttcctctc cccatgagcg gatttatggc tgatgtttcc 281221 ttatcaggtg agattgttta cttccgttat tacggcgaag cgggcagcat catcaagcca 281281 aagcgggtcg cggatgttga agaggcactt gcctttatca agaaggacgt ggagttcgac 281341 cttttgtttg aggttctcca tcgttctgtt tacaaaaacg gagatgatca gccgcatttg 281401 gtgtacgagc ctgaaggtag ggcgattacc gtacctgcgg atttggttca agaagaacaa 281461 gcagttgatg atgacgatga ttacagggag ccggagagct ttcctctccc tttattcgag 281521 ggcatccgcg aaaaggccga tcctgacagc atgattggta ttgaaaatgg gtttgtcaaa 281581 gagcgggaag cggatttggg agatgggaga attggaatcg tttggcggaa tccggatgac 281641 cctgtgtatc agccggcgga taaaagcatg gacagctggt ttaagggacg gactcatcaa 281701 gtgctgaaaa ccatctataa caaagaaacc ggaaaactcg aaggcgtcat gtcatttatg 281761 gagaaaaaag ggccgctgac agtaaccttg gcagagtgtg aaaaaatcgc gcttcgcttt 281821 ctatttgctt tatttccgaa tgccgatcaa tattttagga tcagatacga cgaaaaagat 281881 gaagaagaaa acgcagtcgc tggttttacg tttgaagcgc attgtcacgg agttccgctc 281941 cgatttgggc agatcagaat ttgtgtcagc cgccagacag ggtatatcac cgtttatatg 282001 ggaccggata ttgacccaaa taagctggca accattgatc ctgtgccggc tatttcagtt 282061 gaacaagcca agtctatctt ttggcagcat tttaaagttg agcttggctg ggaaagagag 282121 tacggggatg atgaagaaca cagctaccgg ctcgtctata agccggtgta tccgcatttt 282181 atcgatgcac atacagggga gcctgtcttc agcatatggt gaaacagcca aaagtcacgc 282241 aattgcctca gatatagaag agagtatgtg atgaaagtaa cagaaagaat ctcaaaaaac 282301 aatgacaata atagaaaagg acctttcttc actttaaatg aagaaaggtc tttttatata 282361 ataaacagga ttctctttgt cgtagactct ttgaaaggga tgacttcatt ggttaataaa 282421 cagctgaaaa agaaggcgca ggagatcgga aatgtaccga cgcattatga gcttgagata 282481 gaagattacg accaaaagca aaagaagtac gggcaggcat attttatctg gaaggaccct 282541 aaagatccgg aaaagcacat tacagttgaa cttagaaatg acggcgcctt gctcaccttt 282601 tcaacaactg tccactccga gacagacaaa aaacttccag atgccgagct gaagctgacg 282661 gctcttcagt ttgccgctgc caatcatccc ggcacattta tgaattttca ttttcaaggc 282721 aaggaagaaa gggggcagca catccggttt gtctatacca aaatggagct ggggcttccg 282781 attcccaatt caggcttttt aattgatatg acacgaagcg gtcagattgt ccactttcta 282841 tattacgggg aagggcataa agccgaagtt ccgacggaat ttgtagcaaa agagaaggtt 282901 gtatcccatt acttaaacac aatgtctttt gagctgatgt acgatgtcat tgatggcgaa 282961 caggaaccaa ggcttgtata tgaaccgatt ctaccgggat acagctatcc cgcagatgta 283021 gacgaaattg tgcccgacca gcatatcgca gatgaaagaa tagaaaacac ggcgccactg 283081 ccgccgcttc agaacaagga agaagttgat atatttgcct tgctgggttt tacctctgat 283141 atgcagaaag tcagtgaaag agactttgga gaacaaattg gaagcacgtg gcgcaggggc 283201 gctgcgccgg agcgtaagga tttaagcata ggaagctatt ttgaaacgag aaataaaaat 283261 acaatcaaaa tgaagacgga taaaagaacc ggaaaattaa aagcagcgct ttcttttatg 283321 gactggcgga acaacctcca atgctccacg gaagaatgcc aagagatagc gcttcaattt 283381 ttgtatgccc tctatccgag agcggctgag tttttcaggg tgaatcccgt ccgaattgat 283441 gaaagaggga gagtccgcaa ccatttttct gtctggtata aaggagtgcc gctgcggttc 283501 ggcgctgccc gcatcattgt caatccggaa actgggttga ttgacgcttt tatggcgcct 283561 gatattgaac ctgaacaatt ggaagcgata aatcacaggc cggatgtttc cgctgaagaa 283621 gcgaaagaag catttttagc cgcttttgat gtgaaactgg aatggcagcc tgattttaca 283681 gcaggcagtg accagcactg caaacttgtc tataagccgg tttacccttc ctatattgat 283741 gcgcacataa ggaaaaagaa aaggctgtga ggggtgtcta gttaggaatc atctccaagt 283801 gggggtagtc cttgaatcgt ttccaatccc cgccccattc gaaaccgagt gtcttagcga 283861 tctcgacaac ctccagccaa tctgattttc cgttttgatt gccgtcatat tccatatccc 283921 atatgatgct gccatccttt ttttgaaggg cgaaatcaat cgctaaacca tagttatgat 283981 acgattcccc tcctcttgca taggtgacaa tattcccttt ttttgtacgt ccctgtttat 284041 ataattcatc ttgttcctta aaggacctga atccttcagt aatgacgacg tcaatgcctt 284101 tattcgctgc agcggctttg agtgcatcgg cattctgctt cacaatcgga tgaagatccg 284161 aggggacagg catgtcctgc aaggcgtttt gagaatgcca ttcatgccga atataactaa 284221 aacaaagatc tagaagaaat agaatacata agataacaaa tgtttttgcg ggtaagttca 284281 tatcggtctc actttctcaa gatgtgctga atgttaacgc ttttaagtga ttgactctct 284341 ctaaaagcga acagctatga taaaatataa cataaatagt agcaggagga aggaggcaga 284401 ccgatgagag caaagattcc atcagaagaa gtagcagtaa agctgaatga atggtacaag 284461 ctcattcgcg catttgaagc agatcaagca gaagcgttaa agcaggagat tgaatatgat 284521 ttagaagata tggaagagaa tcaggacttg cttttatatt tttctttgat ggaattccgg 284581 catcgaatca tgcttgataa gctgatgccg gtgaaagaca gcgataccaa gcctccgttc 284641 tctgatatgc tgaacgaaat tgaaagcaat cagcaaaaac tcacgggctt actggaatac 284701 tacttttatt atttcagagg aatgtacgaa ttcaagcaga aaaatttcat attagcgatt 284761 gaccattata aacatgccga ggaaaagctc gagtatgtcg aggatgagat cgaaaaagct 284821 gagtttcttt ttaaagtcgc agaagtgtat tatcacatca aacaaacgta tttttccatg 284881 aattatgcga gccaggcgct tgatatctat acgaaatatg aactgtacgg tcgccgccgg 284941 gttcagtgtg aatttatcat cgccggaaat ttgaccgatg tgtatcatca tgaaaaagca 285001 ctgacccact tgtgcagcgc tttagaacat gccaggcagc ttgaagaagc gtacatgatc 285061 gctgctgcct attataatgt cggacactgt aagtacagtc tgggtgatta caaagaagcg 285121 gagggctatt tcaaaacagc cgccgccatt tttgaggagc acaactttca gcaagctgtt 285181 caagctgtat tttcactgac ccatatctac tgtaaagagg gaaaatacga caaggcagta 285241 gaggcttatg accgcgggat aaagagcgcg gctgaatggg aggatgacat gtacttgacg 285301 aaattccgcc tcattcatga gctgtatctt ggaagcggcg acctgaacgt gcttacagaa 285361 tgctttgacc tgctggaatc caggcagctt cttgctgacg ccgaagatct gctgcatgat 285421 acagcggaac gtttcaatca gttggaacat tacgagtccg ccgctttctt ttaccgcagg 285481 ctgatgaata ttaaaaagaa gcttgccgag cagcgttttc aataggaaat ggcagagaac 285541 tacaggttct ctgctttttt tgtgctgttt tcaactcgga aaaacagggt attttccact 285601 gcatagtgag aaacagagga ggatatcaag tatgtacaaa gatttaaccg gaaaaacagc 285661 gattgtgaca gggtcttcaa aaggaatcgg gaaagccatt gcggaacggt tcggaaagga 285721 gaaaatgaat gttgttgtaa attaccacag cgacccgtct ggagcagatg aaactctgga 285781 aatcattaag cagaacggag ggaaagccgt ctcagttgag gcggacgtgt caaaagaaga 285841 ggggattcag gcgctcttgg acacagcttt agagcatttc ggcacgctcg atgtgatggt 285901 aaacaactcc ggttttaacg gcgttgaggc gatgccgcat gagatgagtc ttgaagattg 285961 gcagagagtg attgatgtca atgttaccgg aacctttctg ggagcgaaag cagcacttaa 286021 ccacatgatg aaaaacaata tcaagggcaa tgtgctgaat atctcaagtg ttcatcagca 286081 gattccgcgc cctgtaaacg ttcagtattc cacatccaaa ggcggcatca agatgatgac 286141 ggaaacgctg gcgctcaatt atgcggataa gggaatccgc gtcaatgcga tagcgcccgg 286201 caccattgcc acagaatcaa atgttgatac gaaaaaggaa gagagcaggc aaaaacaatt 286261 gaaaaaaatc ccgatgaaag ccttcggaaa gcctgaagaa gtggcggcag cagcagcttg 286321 gctcgtatct gaggaagcaa gctatgtgac cggcgcaaca cttttcgtcg acggcggaat 286381 gacactttat ccatctcagc ttgaatagaa gacaaaacag ggggattgcg ggatgaaaac 286441 agactggtgg aaggatgcag tggtgtacca aatttacccg agaagctttc aggacagcaa 286501 tggagacgga attggggact tgcgggggat tatttcccgt cttgactaca taaaggagct 286561 cggggcagat gtgatttgga tttgcccgat ctatccttct ccgaatgttg attacggcta 286621 tgatgtgaca aaccataagg cgattatgga ttcttacgga acaatggacg attttcacga 286681 gctgctggac caggtgcatc agcggggatt aaagctggtg atggactttg tgttaaatca 286741 cacctcggtc gagcatccgt ggtttaaaga agcggagctg gacaaaaaca gcaaataccg 286801 tagctattat tattggcgtc ccggcacaaa gaacggcccg ccgacggact ggctctcaaa 286861 ctatggatgc ccggtctggc aatacgaaga gcacaccgga gaatactatc tccatatgaa 286921 tgccgtcaaa caagctgatt taaactggga aaatcccgaa gttcgccagg cggtgtatga 286981 catgatgaaa ttttggctcg ataaaggggt cgacggtttg cgaattgatc agctccatct 287041 catttctaag aaagaatatc ttccttcgta tgaggactat atcaatcagc aggcagagcc 287101 gaagcccttt cagccaaatg gcgaacgaat ccatgactat ttaaaagaaa tcacagatga 287161 agtgttttct cattatgatg tcatgtctgt cggagaggtc ggcagtgtca caccggaaga 287221 aggcctgaaa tatacgggaa cagataagca tgagctgaat atgatttttc actttcagca 287281 tatggagctt gatcagcagc ccggaaaaga acattgggat ttgaagcccc ttgagctttc 287341 tgatttaaaa tcggttttga caaaatggca aaagaagctt gaacatcaag gctggaatac 287401 attgttttgg tgcaaccacg accagccccg gattgtgtcc agattcggag acgatgggga 287461 ataccgcaaa gcatcagcga aaatgctggc agccgtaatt tattttatga agggcacgcc 287521 gtatatttat cagggagaag aaatcgggat gacaaacgcg ccgttcaccc ggattgaaga 287581 ctacaaagat atccaaacga tcaatatgta tcataaacgg gtgtttgaaa aaggctatga 287641 tccaaatgat gtgatgagat cgatcttagc caaaagccgg gatcacgccc ggaccccgat 287701 gcagtggaac agcggcaaaa atgccggatt tactgacggc acgccttggc tgaaggtcaa 287761 tccgaacttc accgcaatca atgtggagga agcgcaggga gatcctgatt ctgtcttaaa 287821 ctattacaaa aagctgatca gcctgagaaa gcagtacgct gacctcatga aagggagctt 287881 tgatcttttg cttccggacg atccgcagtt gtttgtatac atgagagaaa acagtaaaca 287941 acagcttttg tcggtcaata atttttcaaa agagcaggct gtttttcagt ggcctaagaa 288001 ctgcggcaaa gctcaggcct cactgcttct cagcaattat aacaacgatg atcttgatga 288061 cgaaatggtg ttccggcctt atgagagcag ggtctatctt ctggacaaaa caaactaatg 288121 attgaagtag cccggcattt ttagccgggt ttttttagta catatattcg ctctgcaggc 288181 gggaagaata aatgaaaatg aaatttattc ttgcaaaacg taatgacttc ggtttattat 288241 gatataggat tacaaaatcg ttatcatttt gatttaaagt tactgaaaaa gaggggatat 288301 acgatatgtt taaaaaatgg agcggtttgt ttgtgattgc agcgtgcttt ttattagttg 288361 cagcatgcgg caactcatca acaaaagggt cggcggattc aaagggtgat aaactgcacg 288421 ttgtcacaac gttctacccg atgtatgaat tcacaaaaca aattgtaaaa gacaaaggcg 288481 atgtggatct gttaatccca tcttccgttg aaccgcatga ttgggaaccg acgccgaaag 288541 acattgccaa cattcaggat gctgatttgt tcgtttataa tagtgaatac atggagacat 288601 gggttccgtc agctgaaaaa agcatgggcc aaggccatgc cgttttcgtt aatgcaagca 288661 aaggcattga tttaatggaa ggctctgaag aagaacacga agagcatgat catggggagc 288721 atgagcacag tcatgcaatg gaccctcacg tatggcttag ccctgttctg gcacagaagg 288781 aagttaaaaa tattacggct caaatcgtga agcaggaccc ggataacaaa gaatactatg 288841 agaaaaatag taaagaatat attgcaaaac tgcaggatct tgataaacta tatcgtacaa 288901 ccgcaaaaaa agcggagaaa aaagaattta tcacgcagca tacagctttt ggctatctgg 288961 caaaagaata cggcttgaag caggttccga ttgcagggct ttcacctgac caagaaccga 289021 gcgcagccag cttggcaaag ctgaaaacat atgccaaaga acataatgta aaagttattt 289081 actttgaaga aattgcatcc tcaaaggtcg cagatacgct cgccagtgaa atcggcgcga 289141 agacagaagt gctgaataca ctggaaggct tgagcaaaga agaacaggat aaaggtttag 289201 ggtatatcga cattatgaaa caaaacctcg atgccctgaa agattcacta ttggttaaat 289261 cataagatag tgtgcgccgg aggggtgcac actatttctt tgtgagaaag gaagattaac 289321 atgaatctcg tctcattgaa agatatcgtt ttcggctatt cccatacgcc tgttttagat 289381 aaagtatcac ttgatattga aagcggtgag ttcgtcggca tcactggacc aaacggcgcc 289441 tctaaatcga cgctcataaa ggtaatgctc ggcatgctga aaccgtggga aggcacagtg 289501 acgatcagta aaaggaatac agaagggaaa cgcctgacca tagggtacgt cccgcagcaa 289561 atttcttcat ttaatgccgg atttccgagc acggtgctgg agcttgttca gtcaggccgc 289621 tatacaaaag ggaaatggtt taaacgttta aatgaagaag atcatcttga agtagaaaaa 289681 gcattgaaaa tggtggaaat gtgggacctc cgccatcgta aaatcggtga tttatcaggc 289741 ggacagaaac agaaaatctg tatcgccaga atgctcgcca gcaacccgga tctgctgatg 289801 ctggacgaac cgacgacagc tgttgattac gacagcagaa aaggatttta cgaatttatg 289861 catcatctcg tgaaaaatca caaccgcaca gttgtgatgg ttactcacga acaaaacgaa 289921 gtacagcaat ttttagataa agtgattcga ttagagagag gagaaaaagg cggatggaaa 289981 tgtttgactt ggaattcatg cgacgagctt ttctagcagg cggcatgatc gccgtcatgg 290041 ctccgatact aggagtgtat ctcgttctca gaagacaggc cttaatggct gacacacttt 290101 cacatatctc attgtcaggt gttgccatcg gcttttttct cagcaccaat ataaccgcag 290161 caagcatagt cgtcgtgacc atcggcgcga tcggaattga atacatgcgg cgggcgtatc 290221 ggacttattc agaagtgtcc attgccatct taatggcagc tggtttgtcc ttcgcgatgt 290281 ttttaatcag cctttccaaa ggcacagcca atatgagcat cgatcaatac ctatttggat 290341 cgcttgtgac agtaaaccag cagcaggtct atattatcag tattatcaca ctgctgatcc 290401 tgctttattt tattgtactg agaaggccgc tctacctgct gacgtttgat gaagctacag 290461 ccaaaacatc gggaatcaat acaaacgttc tctcgttgtc attcagtatt gtcacaggcc 290521 ttgcgatttc agtcattatt ccgatcatcg gggtccttct tgtatcggcc ctgctcgtat 290581 tgccggcagc cttcgccatc agaattgcaa aaggctttaa catggttttc attacagcca 290641 tactcatttc attattcagc gtatttacgg gactgacatc atcctatcag ctcgggacgc 290701 cgccaggtcc gtctattacc ctgctattga tcgttttgct attaatcgga tttgcagttc 290761 agggagtttg gacgtttatc aaaaaagaag ctcagcgcaa aaaaagaagc cgataacatg 290821 aaaagcagtt ttccctaggg aaaactgctt tttttataga aacaattcgg caaggcgctc 290881 ataagattct tttttcgcct caaaatcaaa cacattgcac agaaccatga tttcatttgt 290941 ttcgtagcag cctgtgaggt ctaacagctg ttgtttgaca gtggtgggag aaccgatcac 291001 catccgcttt ctgttttctt ctatgagttt tttatcggac gctgtatagg gatgagcttt 291061 cgcttcctcg atgcttggca cgcggctgtc caagcctttt ccgacgcgaa gaagccacag 291121 atcctggctt aatgcgagtt cttctgcctc ttcatctgtt tttgcgcaaa tgacaaaaat 291181 cgtaaacagt gcggatggat tcgaaaaatg ggctgagggc cgaaagcttt cccggtagat 291241 gcggaatgca ttttctcctc gctcgggatt aatgaaatgc ccaaatacat atccaatccc 291301 ctggtgcgcc gcgcgtcttg cgctgttttc accaagaccg agcacccata gctcgggtgc 291361 cgtaccaata aggggcgccg ctttgattcc ggcatacgga tggtcgggag gaagggaatc 291421 tgttagaaaa taagagacat cctgcagctg tctgttaaat tcggttaagc tttttttcac 291481 cccgtccgtt aatgcaagtc tggtttttgt cgtgccgccg ggggagcgac cgacgccgag 291541 gtcaatccgg tttggataca gggcctcaag ctggcgaaag gtttcagcca ctttaaatgg 291601 gctgtattgg ggcagaagca cgccgcctga tccgacacga atggtgtttg tctgtgctgc 291661 gatgcgggcg atcatgattt caggcgctgt gcttgccagt cctttcgtgc tgtgatgctc 291721 ggcaaaccaa taacgcttat agccccactg ttcgcttaat tgggcaagct caaccgaatg 291781 ctggagagtt gtcacagggc tttctccttt agaaacaggt gcctgatcaa gtatgcttaa 291841 atgaatcaaa aggccgcttc ctttctgtct gtttttagat ggtgacacca gaataggcaa 291901 aatgacttgc ccgcgtcaaa tggtttgttt aagaagcgca ctttatagca tttgcaaatc 291961 atatatcaaa tatggaagtt ttttttcgag gtttttcgtc aattattctt aacttttacg 292021 aaactttgat ataataacaa acgtatatat tagtaattta cggcttattt tccttgtgag 292081 cgtaaaaata aatgtgacta tcttcacatt ttgatgagta ggagtgaatc gtgtggcaat 292141 ttctttagaa aaaggtcaac gaattgattt aacaaaagga aaagccggtc tgtcaaaatt 292201 gatggtcggt ctcggctggg acccagtgtc ctcaggcgga ggattcttca gcaaactgct 292261 tggcggaggc ggtccgaata tcgactgtga cgcttcagtg ctgatgctgg aaaacggaaa 292321 attcaccgat aagaaaaacc tgatttattt cggcaacctg aaaagccgct gcggcggtgt 292381 acagcataca ggcgacaacc tgacgggtga cggtgcgggc gatgacgagc aaattatgat 292441 agatttagat aaagtgcctg gaaacatcga taagcttgta tttgtagtga acatttacga 292501 ttgtgtcaga agaaaacaag atttcggcat gattcaaaat gcgtttatcc gcgtagttga 292561 tcaatctaat cacgaggaaa tgctcaagta caatttgaga gacaattacg ccggcagaac 292621 aagcctgatt acagcagaaa tctaccgcag cggcagtgag tggaagtttg cggcggtcgg 292681 tgaaggcaca aacgatacga gattagaaga tattatcagt cgatacgtat aaaagaaaag 292741 gagtggatga aacatgacaa tttcattggc aaaaggacaa aaagtagatt taacaaaaac 292801 aaatccgggt ctttcaaagg ttgttgtcgg tttaggctgg gatacgaaca agtatgacgg 292861 cgggcacgac tttgatcttg actcaagtgt gtttctgtta gacgccgcgg gcaaatgcgc 292921 gtcaccaaac gactttattt tctacaacca gcttgaaggc ggcaacggtt cagtcgttca 292981 ttcaggcgac aacctgactg gtgctggcga aggcgacgat gagaatgtaa aagtaaatct 293041 cagcgctgta ccggcaaaca ttgataaaat ctcatttgtt attaccattc acgatgcaga 293101 agcgcgcagc caaaactttg gacaagtatc aaacgcgttt gtccgcatcg taaatgaaga 293161 aacaaatgaa gagctcatcc gttacgatct tgcagaagat ttctctattg aaacggcaat 293221 cattgcaggg gagctttaca gacataacgg cgagtggaaa ttctcagcaa tcggctcagg 293281 ctaccaaggc ggccttgccc gcattgcaac agactacggt ttgcaagtcg gttaagacaa 293341 atacgaagag cagaaaggag agaggcagta tggccattca attatcaaaa ggacagcgca 293401 ttgatttaac aaaaacaaat ccgggactga ctaaagcggt gatcggctta ggctgggata 293461 caaacaagta ctccggcgga cacgattttg acctggatgc ttcggccttt ttagttgatg 293521 cgcatgataa ctgcgtaaat gatctcgatt tcgtcttcta taataacctt gaacatccga 293581 gcggcggtgt catccatacg ggtgacaacc gcacgggtga gggcgacgga gatgatgagc 293641 agattatcgt tgatttctca aaaatccctg ctcacattga gaaaatcggc atcacagtga 293701 ccattcacga cgctgaagca cgcagccaaa actttggaca agtttccaat gcatttgtcc 293761 gcgttgtgga tgaagaaacg cagaatgagc ttcttcgctt cgatttggga gaagacttct 293821 ccattgaaac agctgttgtc gtttgtgagc tttacagaca cggcggcgag tggaaattca 293881 atgcaatcgg cagcggattt tccggcgggc tggctgcatt gtgccggaat tacggtttgc 293941 aagtgtaagc gagtgacaaa tagagaagtc accgtttcaa attataggag gaaaaaactt 294001 ggacttttta catcatattt tgtctacgta tgcttcattt ttcgattgga aaatgtgggg 294061 ggaagttctg actgatcctg tttcctgggg tttgatcggt tcccttgttg ttctggaagg 294121 ccttttatcg gccgataacg cgcttgttct tgcggtcatg gttaaacacc tgccggaaaa 294181 acagcggaaa aaagcgttaa cgtatggttt gtttggagct tatattttca ggtttatttt 294241 catcgggctc ggtatgcttc tcattaaatt ctggtggatc aaggtgcttg gcgcgcttta 294301 cctggcttgg ctcgtcatta agcacttctg gataggcgaa aaagaagagg aagcggacgg 294361 catgaagaaa aactcttgga tggtccgcac gttcgggatc ttctgggcga ctgtcatttc 294421 agtagaatta atggatcttg ccttctctgt ggacagcatc ctggccgcgt ttgcagtatc 294481 tgaaaaagta tgggtgcttc tgattggcgg tatgcttggt attttaatga tgcgtacagt 294541 ggcaaaagtg ttccttgtgc tgattgataa aattcctgag ctggaaaaca cagcattcgt 294601 cttaatcggc attatcgcgc tgaaaatggc ggggagcgct ttccattacg aaatgccgca 294661 ctctgtattc ttcattatca ttatcgctgc atttgcggta acattgatca ttcactacat 294721 caataaacaa aagcaggtgc gcgaacaaac agccgcttca aaagaagaat aaaacaaaac 294781 aaggagggag gttcaatgtc cttccttttt tgttaccgaa atatcgtttc aatgacaaac 294841 cggaaaggag gatatgatga gacaagaaga actaaccatt cataaagcac ttccggctga 294901 tggcgattgg aaaagcctgc tgtttcagcc attgccggag cgggatcact atgaaactgc 294961 acaaggcctt tctttttctc gtcttgccgg tcagatattg ggcacgccta ttgatgagac 295021 ggactactat aacgagctgt atgagctgtc tgtaaacgac cgcataacga ttttgagtga 295081 aacgcttgat aaaacaatcg aaccggaaac atttcaaaag cttcagcata ttcattccat 295141 caatcagaaa gaaaaagggc tgtcagtcag ccgctttgtt gcctttctgg acggggaaaa 295201 gctgattgcg aagcactcaa atcccttgat gcaccgccat ttaagaaaag cgttgatgac 295261 gcttttacat acctttgcgg acagtcatga aaaggggctg aatcatcctg attttcgcag 295321 agtgctgctt gatgtctcga agttttcctt aaaccatctg aacccttggc tggaaaaaac 295381 cgatatagag cgggagatgc cgaaggttgt ttggtatgga gatgcgacga aaagccagct 295441 ctatttctta tattatctga tgctggtcgg ctgtgatgta ctgctgttcc atccggcggg 295501 aacggatcag ctggcgcttg tcgacccgaa gcaggagctc ggttttacgg aaaagctccc 295561 ggatgtttcg gagcttcagc cgtttccgaa agaaaaacca gaccggaaat caacagtggc 295621 ttaccgctca acaaaggaaa ttgaacatgt gctgaatcac gaggaatcca tgctatataa 295681 gccgtggcag ttcagagatc acacaccggt gtccgttacg ctgaaaacga cctatgatga 295741 attgttttta atcacgaaag aacgcgcctt tattcggccg aatttcaaag ctgataaaca 295801 ttccattgag attccgaatg tattcgccaa aattatgggc gtgtcgaaag acaataagga 295861 atattggaac aggcttcata ctctagcgga ttatcaggaa acagaaatgg tcagaagctt 295921 tccatttaca gaagaaataa agtcgaacta tcaatttcac tacagccacg cacttgatca 295981 agaagggaac attgatccgg acaagctgat ggcaagcaat gtgtggcagt acaaacagct 296041 gccggcgggc gttcagactg ccattgccaa aacgatttcg agaatgtgca ggtacccgcg 296101 gcttaaagcc ttgcatcagg aacaagtcaa ggatgttcaa atctatttgt ttaaacaaac 296161 aacaaacctg cctgctaatc tgctgaaatt gattcaaatg ttcgactatg cgcaaaccgt 296221 tccgaaactc gttttatatc atacggaaat gagcggcgga ctcacgcgtt cggatgctgc 296281 cgccctgctg ttcctgaatg aaatcggaat cgatatcatc atttataatc cgcccggaca 296341 ccaagatatt gagcagttta ttgaagagga tcagtatgat atccactggc tggatgacat 296401 ggtgtttcag caggactaca aagagccttc gcttgtgaaa aggctcttca gaaccattac 296461 ccaaaaataa ggagagaaga aaagcatgac aacagaaaat caaaatccgc ttgttctcga 296521 taaaaatgaa gagatttccc agcaaaaagc tgacgatatc cgtcttcagc tccgtcagga 296581 accagaagtg aagcggcttg ctcaacaaat tgacgtcaaa aaccaaatgg agctgcttga 296641 gtacggcaag gagccggccg ttgaaatatc caagttctct gaccgcatct tggggatgat 296701 gaaaacaaca agcgtgacag actccggcac aatgctgact cagcttggga aaatcatgga 296761 ccgcttcgac aaaaatgatt ttgatgagcc aaagggatta atggcgaaaa ttttcaaacg 296821 cggcggcagc atgattgaaa aaatctttaa aaagtatcag acgcttggcg gagagattga 296881 aaaaatccac gttgagattt caaaatacaa agatgagatg acgaagacga actacacgct 296941 cgatgaaatg tatgaaaaca atatcaaata ctatatggag cttgaaaaat acgtcgttgc 297001 cgggcagatg aaactggaag agatgcagtc gatccttcct tcatatgagg aaaaagcggc 297061 aagcgggaac cagctggcgc aaatgcagct cgatacgttg cgcaacggca ttcaggcgct 297121 tgaggaacgg gtgtatgatc ttgacatggc acggatggtg gcgcttcaaa ccgcacctca 297181 aatccgtctc ctgcagcgag gaaatgcaaa gctgatcggg aaaatcaact ccgcgtttat 297241 cattaccatt ccgattttca aaaacggcat tattcaggct gttacggtaa agcggcaaaa 297301 gcttgtggct gattccatga gcgagcttga ccgccggaca aacgagatgc tgaaacgaaa 297361 tgctgaaaac atctcgagcc aaagtgttga aattgcgaga atggccggca gaccgagcat 297421 agatattgaa acgattgaat cgtcttggaa cacgattgtc agcggcatgc aggaaacaaa 297481 acaaatcgaa gaagaaaaca agcgcctccg cgaagacggc gcgagacgaa ttgcccagct 297541 tcaggataat attaaaaaag cagcattgca gcaataataa aaaccccgct tgtggaacat 297601 aagcggggta tttcaattac atcatttagt taatgacaat gtgtaaagac aggtgtaaac 297661 ttaaacggta atcattttgc atatcagagg tgttggcaat gggaaaacaa cagcctatat 297721 cccagcgtaa actgctgggc gtcgccggtt tggggtggct gtttgatgca atggatgtcg 297781 gaatattatc gtttattatc gccgcgctcc atgtagagtg gaatctgtcg cccgaagaaa 297841 tgaaatggat cggaagcgtc aattccatcg gcatggctgc gggtgcgttt ttgtttggtt 297901 tgcttgctga tcgaatcggc cgcaaaaaag tgttcatcat caccctttta tgcttttcca 297961 tcggaagcgg catttccgct tttgtgacga gcttatcggc atttctaatc cttcgtttcg 298021 tgattggtat gggacttggc ggcgagcttc cagtcgcttc aacactcgtt tcggaagcgg 298081 ttgtgcctga aaagcggggc agagtgattg tgcttttgga aagcttttgg gccgtgggct 298141 ggctcgcagc ggccttgatt tcttactttg tgataccaag cttcggctgg caggctgccc 298201 ttctgttaac tgcgctgact gctttttatg cgctgtacct gcggacgagt ctacctgatt 298261 cgccgaaata tgaatcgctt tctgccaaaa agaggtcgat gtgggagaat gtaaaaagcg 298321 tctgggcaag acagtatata cggccgacgg tgatgctgtc gatcgtttgg ttctgtgtgg 298381 tgttttctta ttacggcatg ttcctatggc tcccgagtgt catgctgctg aaaggcttca 298441 gcatgattca aagctttgaa tatgtcctgc tgatgacgct tgctcagcta cctggctatt 298501 tctctgccgc atggctgatt gaaaaagcgg gccggaagtg gatactcgtc gtttacttga 298561 ttggcacagc aggaagcgcc tatttcttcg gaacggcgga ttccttaagt cttctgctta 298621 cggctggagt gctgttatcg tttttcaatc tcggtgcgtg gggcgtgctg tatgcttata 298681 ccccggagca atacccgact gcgattcgag caacaggttc aggaacgaca gcagcgtttg 298741 gaagaatcgg cggcatcttc gggcctttgc tcgtcggaac cctggcagcc cgtcatattt 298801 cgttttcggt catcttttca atcttttgca ttgcaatctt acttgcggtt gcttgtattt 298861 tgattatggg gaaagaaacg aaacaaactg agctagaata ggaaaagcac ctcttaaaag 298921 aggtgctttc agcgtgtcga caaaccctcg cattcgttgt caggactgcg cttcggtgct 298981 caatgcgaag tggatcaacg gctaaattct caggcgtcct gcctaaacgc cgtcgtcatc 299041 acatcctgtg aatgtccgct cctatgctcg tccttcctag acttcaaggg ttttcaatca 299101 cgctgaaaag attttgtcaa caatctgagg cacctcttga atgaggtgct tttttacaat 299161 tgcgcccggg ctgtggattg gcgtttcccg gttttactga ttgtctggta gagcgtcata 299221 gaaagtatga acagaatggc agtaaatcct gtgacagctc cgaaatgctg tgtgctttga 299281 tataaaaaac ctgcaatact tgtaccgaca gtggttccgg catacatagc ggcattggaa 299341 agggaagcga tggttcctcg cgcatttggt gcaatggatt gaaagacacc catcattaac 299401 ggaaagatga tgccagctgt aaagaacgtg agaaaaaagc cggcttctac taaaaacaag 299461 tttggaaaga acggaagagc gaaatagaga gcgcccatta gcagcatccc gctgatcagt 299521 gttttaaaca tgcccagctt ttctgaaacc cggctgccga taaggctccc gagcatattt 299581 cccagtccga gtacaagcat agctgcgcca atttgtgaca cggttaaatg ataatccgcg 299641 gaaagccaag tacccagaaa gctgaacgat gcgaagtttc cggtttgaaa cagaaaatag 299701 gcaagcagaa tgaccgatgt tttcggcaat gaaaaaagct cccgataggg gttgacaatt 299761 gatgggcgcg ccaatggttc agaaggccgg atgccaggca tgaccgccgc caggatcaat 299821 agaagaataa gcgagcacgc tgacaaaacg aaaaatggcg tatgccatgt aaaggaagcg 299881 agaaaccctc caataggaag tccgagcatt tgtgaagcgg ccaaacctgc tgtcgcaatc 299941 cccatgcctt ttatgatctg agaaggctgg acaatgactg ggatggacgc ccaaatttga 300001 ggcgtcacaa acgcagcgct aacgcctgcg gcaaaacgga acaggcacat ggcggcaaaa 300061 gagggagcga tgccgcataa aaatgtggat acgataaagc ctgcaagtcc ccacagcatg 300121 actgttttcc tgttcagccg gtctgagatt gggcctgcaa tgaaagcgaa gagtgcataa 300181 ccgagtgcat aagcactgac catccagcct gacaaatcag tagagacatg aaactgatcc 300241 tgtaaaaggg ggagaagcgg cgaaagcaaa aaggtatccg tgccaatgac aaacatgaca 300301 ctgaagaaaa gccaaatgcg attcaaattt tatcactcct attgttttat aactttaaaa 300361 ctatgaaaca gatatgtata gagaaaaccc tttgttagag ggtttccaaa aagccaggca 300421 ggtatgtttg aaatgtgtct tcacgcagac tgacgtattt tgtccgcgaa tctttccggg 300481 ttgccgtcaa tcccgcttca cgcagcgttt taaaatgata agatgccgtg gttttgacaa 300541 tattgcactt ttcacctact tcaccgcagc tgagttcttt tccgctgaca taaagcgtac 300601 gaataatggc aagccttgat tcatcagaca gtgctttaaa aatttgcgct ctgatttgat 300661 catctgattg tttcatagtc atgaaactat aatacataat gggtgttgaa aaagcaactt 300721 atttttccag taaaggagca ggaagtcata agaggaagga ggaattcaat tccaataaaa 300781 gcgttttcaa ctaaaggtag gagaaaaatc acccgtaaaa tacaatcata taggaggatt 300841 acagagcatt tagaagcata aataagatca tgtggtcaca tggatgttta taaagaaatg 300901 gtacagaata aaagagaata tgctgtttgt gtgggaagtt acataaatgt tacggtaata 300961 aagattgctt aatatggagg gaaaatatga gtgtagatga gaaaccaatt aagataaaag 301021 tcgagaaagt ctctaagatt tttgggaaac aaacaaagaa ggcagttcaa atgcttgcca 301081 acggaaagac aaaaaaagag atcctgaaag caaccggatc aaccgttggg gttaatcagg 301141 cagattttga agtatatgat ggtgagatat ttgtcatcat gggtctatca gggagcggta 301201 aatcaacttt agtacggatg ttaaaccggc ttattgaacc gactgccgga aatatttaca 301261 ttgatggtga catgataaca aatatgtcaa aagaccagct ccgggaagtc cgccggaaaa 301321 aaatcagcat ggtcttccaa aagttcgctc tgtttccgca cagaacgata cttgaaaaca 301381 cagaatacgg actggagctt caaggtgtag acaaacaaga gcggcagcaa aaagcgcttg 301441 agtctcttaa gctcgttgga ctggaaggat ttgaacacca atatcccgac cagctttccg 301501 gcgggatgca gcagcgtgtc ggccttgccc gcgcgttgac gaatgacccg gacatccttc 301561 tgatggacga agcgttcagt gcgctcgatc cactgattcg taaagatatg caggatgagc 301621 ttcttgatct tcacgataat gtcggaaaaa caattatctt tattacgcat gacttggacg 301681 aagcgttgcg gatcggcgac agaattgtcc taatgaagga cggcaacatc gttcaaatcg 301741 gcacgcctga agaaatcctg atgaatccat ctaacgaata tgttgagaaa ttcgtcgaag 301801 atgttgattt gtctaaagtc ctcacagcag gccacattat gaaacgcgct gaaacagtgc 301861 ggattgataa agggcctcgc gtagcattga cactgatgaa aaaccttgga atttcttcaa 301921 tttatgcagt ggataaacaa aagaaattat taggtgttat ctatgcgtct gatgcgaaaa 301981 aagcggctga gtctgatttg tcacttcaag acatcttgaa tacagaattt acgactgtac 302041 cagagaatac gtatctgact gagatttttg acgttgtgtc cgatgcgaat attccaattg 302101 cggttgtgga tgagaagcaa agaatgaaag gaattgtcgt aagaggcgcg ctgattggcg 302161 cacttgccgg caataacgag tatatcaatg ctgaaggcac taacgaacaa acacaagatc 302221 cttctgcaca ggaggtgaaa taagatggat agactgccta gaataccttt agcagatatt 302281 attgaccgtt ttgttgactg gattacgatg acgtttggcg gattcttcga cggaatcgct 302341 aacggattgg ccgcttttgt aaatggaatt gtcaccggtc ttggatttat tccatctatt 302401 ttgttaacga ttattttcgc cgcacttgcg tggtggatca gtacaagggg aattgcgtta 302461 tttacgttga ttggattcct cctgatcgat tatttaggat attgggaccc aatgctgcaa 302521 acattggcgc ttgttttgac atctgtgatt atttcgattg tggtcggggt tccgatcgga 302581 atttgggcgt ctcagaaaga aacggttcgc cgtattgtaa cgccaattct tgatttaatg 302641 cagacaatgc ctgctttcgt atatctattg ccggcgattt tcttctttaa catcggtgtt 302701 gtgccgggtg ttgttgcatc tgttatcttc gcgatgccgc cgacaatccg catgactgtt 302761 ctcggtatta aacaagtgcc ggcggatttg attgaagcga ctgaggcatt cggttctaca 302821 acagctcagc gtttgtttaa agttcagctc ccgcttgcga caaaaacgat tttggccggg 302881 atcaaccaga gcatcatgct tgcgttatca atggttgtta tcgccgcaat ggtcggtgca 302941 ccgggacttg gttctgaagt atacagtgcc gttacacagc tgaaaaccgg ggtcggagta 303001 gaggccggta tcgccatcgt tatcgttgcc attaccctgg accgtattac tcaaaatatt 303061 aaagtgaaga agaaaagcag ggggaatgcc tgatgcttaa aaaaatcata ggcatcggcg 303121 tttccgccat gctggcgctc tcacttgcgg cttgcggttc agaaaacgat gaaaatgcat 303181 ccgcagcaga acaagtgaat aagaccatca tcgggattga ccccggttca gggattatgt 303241 ccctgactga caaagcgatg aaggattatg acctgaatga ctggacattg atttcagcgt 303301 caagtgctgc gatgaccgct acgcttaaaa agtcatacga ccgtaagaaa ccgattatca 303361 ttacaggatg gacaccgcac tggatgttct ccagatataa gctgaaatat ctcgatgatc 303421 cgaaacaatc ttatggcagc gcagaggaaa tccatacgat cacacgcaaa ggcttcagca 303481 aagagcagcc gaatgccgca aagcttctga gccagtttaa atggacgcag gacgaaatgg 303541 gcgaaatcat gatcaaggtg gaagaaggcg agaaacctgc caaagttgct gctgagtacg 303601 tcaataaaca caaggatcag attgccgaat ggacaaaagg cgttcaaaag gtgaagggag 303661 acaaaatcaa ccttgcctat gtggcgtggg acagtgagat tgcaagtaca aacgtcatag 303721 gcaaagtctt agaagacttg ggctatgagg taacacttac tcaggtagag gctgggccga 303781 tgtggactgc aattgcgacg ggaagtgcgg atgcatccct ttccgcatgg ctgccgaata 303841 cccataaagc atacgccgct aaatataaag gcaaatatga tgatattggc accagtatga 303901 ctggtgtgaa gatggggctt gttgttcctc aatatatgaa aaatgtcaac tcaattgaag 303961 atttgaagaa gtaatcaaaa aagcagcctg tgtcaggctg ctttttttgc gttaagaagc 304021 gttagcggca gcaagtgatt ccgccttctg aaatgttttg agcacggcgt tcgccaaaat 304081 atgaatgccg gtaaacatcg catttctgtc aaaggtcatg tgcggatgat ggagccccgg 304141 ctggagcccg cagcctagtc cgagcatcgt tgttttcaga ttcggcacct tcacggcgta 304201 aaaatggaaa tcctcgccgc cggtggtgac aagcgggtca tcaagccgct cagccccgat 304261 gatttccgta atggcttctg ccatgatcgc ttcagcttct ttattttgtg ttgccgcagg 304321 aaggctgtgt tctttgtgca gctcgatctt tgcgccaaat gcagcggcgg ccgcttcaca 304381 ggctctttct gtttcggcga ttaatgcctc catggcttca ttggtctgtg cgcgcaaatc 304441 aaggctgaac gatgcttttc ctggaatgat gttagagctt tcaccgccgg cttgcagttt 304501 tgtcattttg acggtatgcg ggatttgcgg gtcaatatga atgagtccga gcttgtgtac 304561 aagaaatgcc gcaatttcaa tgctgttttt cccgaggtgc ggacgggcgc catgagcctc 304621 ttccccgatg atcgttccct caatgtgctg gcttgatccg tgcagaatag aaggagcgca 304681 gcggccgttc tgtgtttcct ggatcggacg gacgtgaacg ccatacaaat agtcgatatc 304741 atcaagcacg ccttcttcta tcattttcaa ggcgccgccg cctttttctt ctgccggctg 304801 aaagataaaa cggattgtgc ccttcggaag ctcaggttgt ttttttagca gcattaacgt 304861 gcccaatgcc attgtcatat gtgaatcgtg tccgcaggaa tggttggcgc gaaatgtgcc 304921 gttaacctcc tgccacagcg cgtcaatatc agcgcgtacc gctacaacag gtgagcctga 304981 gccgatttcg ccgacaaccc cggtgcagtc tgaaaacgtg cgcgtccggc accctaaatc 305041 ctcaagcttt tgtttcaaaa atgaagttgt ctcatattcc ttccagctga cttcagggtt 305101 cgcgtgcaga tgctcgaaga tgtccataat ggtttgtttc atttcttctg aaagcttttg 305161 catggtaaga aatacctcct tctatcagaa tgaattttta ccttctttac tttatttata 305221 ttgaaacagg aagataggct gtatataata tagcacatat tgctactatt cagaataatt 305281 aatattttca aacagagggg atggatcgaa atatgagtat gccagcagcc gaaacacagc 305341 ctaagaaaaa acgtatgaca tttaaaatgc ctgacgccta tgtcctctta tttatgattg 305401 ctttcatttg cgcaatcgct tcatatattg tgccggcagg tgaatttgac cgcgtgacaa 305461 agggggatgt cacgaccgct gttccgggaa gctatcattc aattgaacag tctccggtca 305521 gattgatcag cttttttact tctctacagg atggaatggt tggatcagca cccatcatct 305581 ttctgatttt attcacaggc ggcaccattg ctattctaga aaaaacgggt gccatcaatg 305641 gcctgattta caatgtcatc agcaaattcc gcacaaagca attattattt atttgtattg 305701 tcggcgcatt gttctccatt ctcggaacaa ccgggattgt cgtgaattca gttatcggtt 305761 ttatccccat cggcctcatt gtggcacgat ccttaaaatg ggacgcagtc gcgggagccg 305821 ctgttatata catcggctgc tacgctggat ttaactccac catattatca ccgtcaccgc 305881 tcggtttatc acaatcaatc gcggagctcc ctcttttctc aggaatcggc ctgcgagttg 305941 tgatatacat atgctttttg ctgtcttcta ttatttatat ctatttgtat acgagaaaat 306001 taaaaaaatc aaaagatgcc agtgtgttag gaacagattg gttccctgcg gcaggaatgg 306061 gcgaagccgg taaagaagaa gatcagtcag tgccgtttac cgttcgccat aagctgattt 306121 tggctgtggc gggactctca cttgtcggat ttttatacgg cgctttgaag cttggctggt 306181 cagattccca aatggctgcg acatttattt ttatttctgt ccttgccggt ttaataggcg 306241 ggcttgcggc gaacgatatt gccaaaacct tcattacggg ctgccaaagt cttgtatacg 306301 gggcgctgat tgtcgggatg gcacgaagca tttccgttat ccttgaaaat ggaaagcttc 306361 tcgatactgt cgtcaatgct ttggcttcac ttttggatgg attcagcccg attgctgggg 306421 caatcggcat gtatatcgcc agtgcgctgc ttcattttct catctcttca ggttctggcg 306481 aagccgttgt atttattcca atcctggcgc cgctcgctga tttgatggga atcacgagac 306541 aggttgcggt tgaagcggtt atgcttggag aaggggtcgt caactgtgtg aacccgacat 306601 ccggcgttct catggcggtg cttgccgcca gcggtattcc gtatgtcaag tggctgcggt 306661 ttatggtgcc gcttgctctg atttggttct tgatcgggct tgtctttatc gtgatcggag 306721 tcatgatcaa ttgggggccg ttttaacgat tgctgcccgc cggcttgtac ggcgggcttt 306781 tgagttattc attgcagaag cgcaggctgt tattgtaaca tgtaagccat aagccattcg 306841 taaaagtgcg ggaggaaggt catgaataat ctgcgtaata gactttcagg cgtgaatggg 306901 aaaaataaga gagtaaaaga aaaagaacaa aaaatctggt cggagattgg gatgatagcg 306961 ggagcatttg cgctgcttga tgtgatcatc cgcggcatta tgtttgaatt tccgtttaaa 307021 gaatgggctg caagccttgt gtttttgttc atcattatct tatattactg catcagggct 307081 gcggcatccg gaatgctcat gccgagaata gacaccaaag aagaactgca aaaacgggtg 307141 aagcagcagc gaatagaatc aattgcggtc gcctttgcgg tagtggtgct tacgatgtac 307201 gacaggggga ttccccatac attcttcgct tggctgaaaa tgattcttct ttttatcgtc 307261 tgcggcggcg ttctgtttct gcttcggtat gtgattgtga agctggctta cagaagagcg 307321 gtaaaagaag aaataaaaaa gaaatcatct tttttgtttg gaaagcgagg gaagcgttca 307381 cagtttcggg cagctttttt tataggaaca ttgatttgta ttcactctgc caagttgttt 307441 tgatagagtg attgtgataa ttttaaatgt aagcgttaac aaaattctcc agtcttcaca 307501 tcggtttgaa aggaggaagc ggaagaatga agtaagaggg atttttgact ccgaagtaag 307561 tcttcaaaaa atcaaataag gagtgtcaag aatgtttgca aaacgattca aaacctcttt 307621 actgccgtta ttcgctggat ttttattgct gtttcatttg gttctggcag gaccggcggc 307681 tgcgagtgct gaaacggcga acaaatcgaa tgagcttaca gcaccgtcga tcaaaagcgg 307741 aaccattctt catgcatgga attggtcgtt caatacgtta aaacacaata tgaaggatat 307801 tcatgatgca ggatatacag ccattcagac atctccgatt aaccaagtaa aggaagggaa 307861 tcaaggagat aaaagcatgt cgaactggta ctggctgtat cagccgacat cgtatcaaat 307921 tggcaaccgt tacttaggta ctgaacaaga atttaaagaa atgtgtgcag ccgctgaaga 307981 atatggcata aaggtcattg ttgacgcggt catcaatcat accaccagtg attatgccgc 308041 gatttccaat gaggttaaga gtattccaaa ctggacacat ggaaacacac aaattaaaaa 308101 ctggtctgat cgatgggatg tcacgcagaa ttcattgctc gggctgtatg actggaatac 308161 acaaaataca caagtacagt cctatctgaa acggttctta gacagggcat tgaatgacgg 308221 ggcagacggt tttcgatttg atgccgccaa acatatagag cttccagatg atggcagtta 308281 cggcagtcaa ttttggccga atatcacaaa tacatctgca gagttccaat acggagaaat 308341 cctgcaggat agtgcctcca gagatgctgc atatgcgaat tatatggatg tgacagcgtc 308401 taactatggg cattccataa ggtccgcttt aaagaatcgt aatctgggcg tgtcgaatat 308461 ctcccactat gcatctgatg tgtctgcgga caagctagtg acatgggtag agtcgcatga 308521 tacgtatgcc aatgatgatg aagagtcgac atggatgagc gatgatgata tccgtttagg 308581 ctgggcggtg atagcttctc gttcaggcag tacgcctctt ttcttttcca gacctgaggg 308641 aggcggaaat ggtgtgaggt tcccggggaa aagccaaata ggcgatcgcg ggagtgcttt 308701 atttgaagat caggctatca ctgcggtcaa tagatttcac aatgtgatgg ctggacagcc 308761 tgaggaactc tcgaacccga atggaaacaa ccagatattt atgaatcagc gcggctcaca 308821 tggcgttgtg ctggcaaatg caggttcatc ctctgtctct atcaatacgg caacaaaatt 308881 gcctgatggc aggtatgaca ataaagctgg agcgggttca tttcaagtga acgatggtaa 308941 actgacaggc acgatcaatg ccaggtctgt agctgtgctt tatcctgatg atattgcaaa 309001 agcgcctcat gttttccttg agaattacaa aacaggtgta acacattctt tcaatgatca 309061 actgacgatt accttgcgtg cagatgcgaa tacaacaaaa gccgtttatc aaatcaataa 309121 tggaccagag acggcgttta aggatggaga tcaattcaca atcggaaaag gagatccatt 309181 tggcaaaaca tacaccatca tgttaaaagg aacgaacagt gatggtgtaa cgaggaccga 309241 gaaatacagt tttgttaaaa gagatccagc gtcggccaaa accatcggct atcaaaatcc 309301 gaatcattgg agccaggtaa atgcttatat ctataaacat gatgggagcc gagtaattga 309361 attgaccgga tcttggcctg gaaaaccaat gactaaaaat gcagacggaa tttacacgct 309421 gacgctgcct gcggacacgg atacaaccaa cgcaaaagtg atttttaata atggcagcgc 309481 ccaagtgccc ggtcagaatc agcctggctt tgattacgtg ctaaatggtt tatataatga 309541 ctcgggctta agcggttctc ttccccattg agggcaaggc tagacgggac ttaccgaaag 309601 aaaccatcaa tgatggtttc ttttttgttc ataaatcaga caaaactttt ctcttgcaaa 309661 agtttgtgaa gtgttgcaca atataaatgt gaaatacttc acaaacaaaa agacatcaaa 309721 gagaaacata ccctggaagg atgattaatg atgaacaaac atgtaaataa agtagcttta 309781 atcggagcgg gttttgttgg aagcagttat gcatttgcgt taattaacca aggaatcaca 309841 gatgagcttg tggtcattga tgtaaataaa gaaaaagcaa tgggcgatgt gatggattta 309901 aaccacggaa aggcgtttgc gccacaaccg gtcaaaacat cttacggaac atatgaagac 309961 tgcaaggatg ctgatattgt ctgcatttgc gccggagcaa accaaaaacc tggtgagaca 310021 cgccttgaat tagtagaaaa gaacttgaag attttcaaag gcatcgttag tgaagtcatg 310081 gcgagcggat ttgacggcat tttcttagtc gcgacaaatc cggttgatat cctgacttac 310141 gcaacatgga aattcagcgg cctgccaaaa gagcgggtga ttggaagcgg cacaacactt 310201 gattctgcga gattccgttt catgctgagc gaatactttg gcgcagcgcc tcaaaacgta 310261 cacgcgcata ttatcggaga gcacggcgac acagagcttc ctgtttggag ccacgcgaat 310321 gtcggcggtg tgccggtcag tgaactcgtt gagaaaaacg atgcgtacaa acaagaggag 310381 ctggaccaaa ttgtagatga tgtgaaaaac gcagcttacc atatcattga gaaaaaaggc 310441 gcgacttatt atggggttgc gatgagtctt gctcgcatta caaaagccat tcttcataat 310501 gaaaacagca tattaactgt cagcacatat ttggacgggc aatacggtgc agatgacgtg 310561 tacatcggtg tgccggctgt cgtgaatcgc ggagggatcg caggtatcac tgagctgaac 310621 ttaaatgaga aagaaaaaga acagttcctt cacagcgccg gcgtccttaa aaacatttta 310681 aaacctcatt ttgcagaaca aaaagtcaac taaccgcaac tttagagtaa agggctgatt 310741 gtcaatgtgg gagcagttgt atgatccgtt tggaaacgag tatgtgagcg cacttgtggc 310801 gctcactccg attctctttt ttcttttggc tttaactgtt ttgaaaatga aaggcattct 310861 tgcggcattt cttaccctag ccgtcagttt cttcgtctcc gtttgggcat ttcatatgcc 310921 ggttgaaaaa gcgatttctt ctgttttgtt aggaatcggg agcgggctgt ggcccattgg 310981 ctacatcgtc ctgatggcgg tgtggctgta taaaatcgcc gtgaaaaccg ggaaatttac 311041 cattattcgg tccagcattg ccggcatttc gcctgaccaa cgattacagc tattattaat 311101 tggtttttgt tttaacgcgt ttttagaagg cgcggccggt tttggtgttc cgattgcgat 311161 tagtgcggcg ctgctcgtcg aacttggttt taaaccgtta aaagcggcgg cgctctgctt 311221 gattgcaaac gctgcctccg gagcctttgg ggcgattggg attcctgtca tcacaggggc 311281 gcagattggt gatttgtctg ctcttgagct gtctcggaca ttaatgtgga cactgccgat 311341 gatctcattt ttaataccat tcctgcttgt attcttatta gaccgaatga aaggaatcaa 311401 acagacatgg cccgctcttc tggttgtgag cggtgggtat acagcggttc agacactgac 311461 aatggcggtg ctcgggccgg aattagcaaa cattttggcg gccttattca gcatgggcgg 311521 gcttgccctc ttcctccgca aatggcagcc gaaagagatt taccgcgagg aaggggccgg 311581 cgatgctggt gagaaaaagg cataccgtgc cgctgacatt gcgaaagcgt ggtctccttt 311641 ctacatttta actgcggcga tcaccatctg gagccttcct gccttcaaag cgcttttcca 311701 agaaggcggg ctgttatatc aatcaacgct cctgttcaaa atgccttttc tgcatcagca 311761 aattatgaaa atgccgccga ttgcgccatc tgccatgccg ttagatgcag tctttaaagt 311821 tgatctgctg tcagcgactg gtacagcgat tttagcggcg gtcatcgtga cagggctgtt 311881 cagcaaaaag ttctcctctc gggatgcctt tgcttccttg aaggagacgg gaaaagagct 311941 gtgggtgccg attatgacga tctgcttcgt gatggggttt gccaatctgg ccaacttcgc 312001 agggctcagc tcttcaattg ggttagcatt ggcgaaaaca ggagacctgt tcccgtttgt 312061 cagtcctgtt ctcggctgga ttggcgtgtt catcaccggt tctgttgtca gcaataatgc 312121 tttgttcggc catttgcagg ttgtcacggg agcgcagatc ggtgcgggtt cagatttgct 312181 gttagccgca aatacggcgg gcggtgtcat ggcgaaactt gtttctcctc aatctatcgc 312241 catcgctgcc gcagcggtcg gccaaacagg caaggaatct aaactgttta aaaggacagt 312301 ggcgtacagc ctgattctgt tattgatcat ttgtatatgg acgtttattc ttgcaagatt 312361 aggagtgtaa tagaaaaaag cagtacatgc ccagcatgta ctgctttttt tatgttaatt 312421 tgctttcttt gtcatttcgg ctgttgtttt cactctggct tttcccataa ataaaatggt 312481 aaccgccgcg aggacaattg gaatcaaagc gagcaaaaag acatacgtga tacttgatga 312541 catcgcgtca ataatgcgat tcaggatcgc atcaggaatc tgggaacgtg ttcccgcttg 312601 gaatatctcc tgcgggtcgc caatattttg cgcagcgcct gatcccgctg agcctttcat 312661 accgctgaag gcgtcattca gcttgtttgt gaatacgttt gtttgcaccg ttccgaaaat 312721 ggtgacacct aaggtcatgc caaatgatcg caaaaatgaa tttgtagagt ttgccgttcc 312781 ccgaaagcga ggttcaagat cattcatcga tgccgccggc agcagggaga agttaaagcc 312841 tacaccaaag cctgaaatca tcataaagac tgtcagccat acccgtgctg tgtcaggcgt 312901 catattggaa agaagcagca tgccgataaa gaaagctata acagatatca gcatcaaatt 312961 gcggaagctt gccttcgttt ggaagatccc gccgatcatg cttccgatga ctgatccaat 313021 catcatcggc gtcagaatga agcccgcgct tgtcgccgag ctgccgtaga ccgcctgaac 313081 gaaaatcgga ataaataccg ctaaaataat aaatgttccg ccatacagga aagcgagaat 313141 ctgtgctgtg gcaaacaagc ggttcttaaa catccagaaa gaaataatcg gctcttctgc 313201 ttttctctcc acaataaaaa aggcaatgaa gaaaacggcg aatacaataa acagcccgat 313261 gatctgaatg gagttccaat cgtatgtttt gccgccaagc tcaagggcga acatcaggca 313321 tacaatggat acgactaagg taatcgcgcc gccccagtct attttctgct ttctgtgctc 313381 cagagattct ttgtagtagc gaataatgaa aaacaatgac aatgcgccga tcggcacatt 313441 gatgtaaaac acccagtgcc agctgatcga atctgtaatg atcgcgccta agagcggacc 313501 aagaacactg gataatccaa atacagcacc gaacatgccg gacatttttc cgcgtttttc 313561 cggcggaaac aaatcaaaga taatggtaaa ggcaatcggc aggagcgcgc cgcctccgat 313621 cccttgaatg gcccggaaga tgatcagctg attcatcgtc tgggcaatcc cgcataaagc 313681 agaaccgatt aagaaaaaaa taagtccaaa caggaaaaaa cgttttcggc cgtacatatc 313741 ggaaagcttg ccgtaaatcg gcatgccagc cataaccgcc accatatagg atgccgtcac 313801 ccaggcaaat ttatcgaagc ttccaagatc ggctacgata ttgcccatcg cggtggcaac 313861 aatcgtattg tccattgcag acatcaagat gcccagcagg agaccgagga ccacaaattt 313921 ggtggaagcc tgttttgctg ttgttgtgtc catttgttct acctcctctt acttttctat 313981 gtaagttctg atatcatgat aatagtttga ttgttgaata tctcgattat caagataaac 314041 tcgattttat agggaggact gtcagttgtc aacaagaaat tccagaagtg agttggaaaa 314101 gactgctgtt cagctttttc gaaaactggg cacaagaacg gttctgtttc atcaggcagc 314161 cgctcaagct ctcggtctgt ttcccaccga tttgaaatca gctgacattt taaatgaagc 314221 agggccgatg acggccggag agctggggaa aaaaaccggc ctcagcacgg gttccgtcac 314281 ggcgcttgtt gaccggctgg aaaaagcggg gtatgtggct cgtgaaaagg acccgaacga 314341 tcgcaggaga gtcgtaatcg tccctttgac tgcttcgaaa aaacatataa aggatttgtt 314401 ccgtcctctg tctgagtcaa cgatggattt gtgccgcgaa tatacggaag aggagctgga 314461 actcattttc agttttgtag gcaaagctgc cgatattatg gaggaagagc ttgaacgtct 314521 gaaacagtaa gtgaatttgt gcatagcttg gcccgttccc gaataaattg tacaagttac 314581 ataagagaag ggagtacggg ccggtgaaca tttttttgag ctatattgtg ctgggactgt 314641 ccttgtctgc gcctgtgggg ccagtgaatg cggcgcaaat agacaaagga attaaaaacg 314701 gtttttggca tgcatggatt ttcggtttag gcgccatgac agcggatggg ctgtacatgc 314761 tttttatcta tttcgggctg tcgcagttct tgaccgctcc atttgtgaaa acgtttttgt 314821 ggctgttcgg cttttttgtc ctgacctata ccggaattga aacgctgaaa aacgtcagag 314881 aaccgatgga tgtgcgaagc tcgcggggga aaccgtcata caggaaaaca ttcgcatcgg 314941 gttttctcat ttcattgtca aacccattga gcatcctttt ttggcttgga atttacggaa 315001 gcattcttgc gaaaacagca gaggcctaca atatgaatca gcttctaatc tatagctccg 315061 gcatcatgat cggcatttta atctgggatt tctgcatggc tatcacagcc agtacgttca 315121 gaaacctgct tcatgaaaag ctattgagag gattgaccgg aatcgccggt gtatccctcc 315181 ttgtgtttgg cttttacttt ggttatcagg gcatcaaaca gttattgggc tgattcatga 315241 aggacagtca cctgccgctt ccagttttaa tatagtatcc agatgatact ggaggtggat 315301 caatggtgaa tgggatttac accaaaagtt ttctggaacg tattcaggaa gagcttcctg 315361 aatggcaaag aatcgctttt gagctgctgg cagaaactct gggggacgac gcggatacat 315421 ttccgtgcat tcccggacgc caggcgtttc tgactgatca gcttcggatt gcttttgccg 315481 gagatccgcg ggaaaaccgc acagcggagg aactggctcc gttgcttgcg gagtacggca 315541 agatatcgcg ggacacggga aaatacgcat ccctcgttgt gttgtttgat acaccggaag 315601 atttggcgga gcattattcg attgaagcgt atgaagagct gttttggcgc tttttaaata 315661 gactgagtca tcaagacgaa aaagaatggc cggaagacat tccggccgat cctgagcatt 315721 ataaatggga gttttgtttt gacggcgagc cgtatttcat tctgtgcgct acaccggggc 315781 acgaggcaag aagaagccgg agctttcctt tttttatggt cacgtttcag ccaaggtggg 315841 tgtttgatga cctaaatgga tcaactgcat ttggccgtaa catgagcagg ctgatccgat 315901 ctcgtttaga ggcctatgat caggctccga ttcacccgca attaggctgg tacggaggaa 315961 aagataatcg tgaatggaag cagtatttcc tccgtgatga cgaaaaacag gtatcgaagt 316021 gcccgttttc ttatttaaag aacatgttca acaaaatgaa ataaatcaag gactggcagg 316081 gcgatcttta tgaccctgct ttttttgata gatcatggta acgatggcga taatcacgag 316141 aaaacctatg ctgacgaaaa aaccgggccg gcttgatttt tcaaacaatg taccggacac 316201 agctgcagca atcagaacca tcgctaaata aatttgcgtt tttcccatgc cctcgggatc 316261 agtcagcttt ttgctggaga acaggataaa cagccaagtg tataaaagca taagccccgc 316321 agctgttgtc atatgctcat aaatgttttt aggcagcact aacgacaaaa taatggagag 316381 gacaagcccc gcaaacgtca gcccaagtgc cggccagcat atttttttgc cttcctttag 316441 agtaaagcat ttcggcgcgt cgccgtcatc agccattgta caaagcaatg tcgtaaccgc 316501 aaatagcgaa gcgacaaggg tcgagaaccc tgcgatgatg aaaatcccgt taaatatatc 316561 aaggatgatc tcaaggttat atccttttaa tgacgtaatg aacggactgt cctgttcagt 316621 aaacgtgtgt aacggaacca aaagcagagc aagcccgatt gaaatgatat aaataatcgc 316681 cagcgtcgcc agcatcagtt tccctgattt agacgcttcc tcaggttttt ttaagtgaac 316741 cgccatcagc cccatgacct caattccgcc aaaagcgtaa aacgcgtaga ttaaacctgt 316801 ccacagcccc atggcgccgt atgggaaaaa ctcactcgtc ttatttggaa catgtatgcc 316861 atgatttccg ccggacagga taccgcataa agccaggatg gcaatgacaa taaacataaa 316921 aatagcagct gttttaatga ctgccagcac gttttctgtt ttttcaaaga cggacaggcc 316981 ggtgaaaata ataaggagcc caagtactgc gtagattgag gcaaacaccc atagcggcac 317041 ttgaggaaac caatgcttcg taaagagcga aatggctgtc agctggcttc cggtaatcag 317101 catttctgat gtccagtaca cccagccgtt gctgaagcct gcccatttgc cgaatgcttt 317161 tcgggcatac gcacaaaacg agcccttttc cggctgcttc gccgatagct tggcgagctg 317221 ttcaaagaca aaatacgtac cgatccctgc gatcagaaat gaaaggagaa cggaaaaacc 317281 gctttttaca attgcgatgc tggaaccgag aaagaagcct gttccaatcg tgcagccgac 317341 tccgatcagt gacagctgcc accaagccag attccctttt ggctggtctt tttttgtttg 317401 gctcattatt tattcaaccc cttttatcta aggttagatt gtgatctgtc caaagcttat 317461 atacatcgga tttttgcctc tttttacatg gagaaggaag cagacgctca tactaatgaa 317521 aaaaggagca aaccaatgac acagcaatat attgtggagc cgaaaaaagg gcttgggctg 317581 aagctgaaaa aggggcagat tttaaaggtg gttgatgtag aagggcagca ggtggctgat 317641 tttgtcgcat accatgccaa ggatttttat gaacaccttg atcagggagc gacgatagac 317701 gccaatcact ccattcatgt gaaggtcaac gaccatctct actccaacct gtataagccg 317761 atgttaaccc tgattgaaga tacggtcggc aagcatgatc tgctgttgcc cgcctgccgt 317821 cctgatatga acaggctctt atatgggaag caaaaggatg agtttcagga tacgtgctat 317881 gacaatatga accgtgcgct tgagcagttt ggcgtaccga agccccacat gcattaccca 317941 tttgcgattt ttatgaatac tgtccttgat gagaaaggga atctgtctgt ggaaacgccg 318001 ctttcgaatg ccggagatta tgtaaggctc agggcggaga tggatttaat tgtcgcgttt 318061 tcttcctgcc cgattgaaaa agggaaatgc aatggcgaca gtgtgacatc catacgggtt 318121 gaagtcagct gatctctctt gttcacagtg aatgaagacc tgtgctatat ttaataggga 318181 tacataacag tcatgattca ttttcattga tttagggaaa tgatcagtaa taagggaaaa 318241 tgtacaggag gaatgattgg gatgagcatg caggaaaaga ttatgcgtga gttacatgtg 318301 aagccctcaa ttgatccaaa gcaagaaatt gaggaccgag tcaatttttt aaaacaatat 318361 gtaaagaaaa ccggtgctaa aggctttgta ttgggaatca gcgggggcca ggattcaaca 318421 cttgcgggaa gactcgctca gcttgcggtg gagagcattc gcgaggaggg cggagacgct 318481 caatttatcg cggtccgtct tccgcatggc acacagcagg atgaagacga tgcccagctt 318541 gctttgaagt ttattaagcc ggataaatca tggaagtttg atattaaatc gacagtcagc 318601 gctttttctg atcagtatca gcaggaaaca ggcgatcagc tgacggactt taataaagga 318661 aacgtaaaag caagaacaag aatgatcgcg caatacgcga tcggcggcca ggaaggtctt 318721 cttgtgttag gaacagacca tgctgctgaa gcagtgactg gtttctttac gaagtacggt 318781 gacggcggag cagacctcct gccgctgaca ggcttgacga agcgccaggg aagaaccttg 318841 ctgaaagagc tgggtgcacc ggaacgctta tacttaaaag aaccgactgc cgatctgctc 318901 gacgaaaaac cgcagcagtc ggatgaaaca gagcttggca tttcctacga cgagattgac 318961 gattatctcg aaggaaaaga agtatcagcg aaagtatcag aagcgctgga aaaacgctac 319021 agcatgactg aacataaacg ccaggttccg gcgtctatgt ttgatgactg gtggaaataa 319081 gttgaagaaa gcccgctctc ggagcgggct tttgtcgtgt acagaagctt tatttgatgc 319141 ggatatgatt cagctttacc attaatctgt cggcgaacct tcggaggctg cctcttgtat 319201 caggatctaa tgggagttcg gctctcgcgg caatgttctc tgccacatcc tgaatcgaca 319261 ggttgtctgt ttgaatgtgg tcctcaaaaa tgggtgatga taatccttca acacagcggt 319321 caatttgttt ggcggcccat gagttttttc cttctgctct ggtgcgcagc ctttttaaca 319381 aggtttcctt tgaagccatt agtgtaaagt ggtgaacgat cctgccttcc tgtctgagcc 319441 tgccgatgat ctcattgaag tattcagggt gtacaatcgt cataggcaca ataaggatgc 319501 cgcggtatgt atctgtcaga gaagctagca aactgtaatt gaacgcccgc cataaaggat 319561 agctttgaaa atcgtccttt gcgatctcct gcggcaccat ggagcgcagc gcaaaaccca 319621 ttttctcggg atcatacacg taagatgggt tcagccttct gtgcagttcg aaggctgttt 319681 gtgtttttcc cgaaccgaat gccccgttta tccaaatgat catcgccatt tctcccttcc 319741 tatttatcat acagaaaaag acccttccat cgaagagtca gctggaaaaa caataaaggc 319801 ggaaggtttt aacgcttttt tgcgtcgaag tattaaaata cctgcagaaa tgttgtacaa 319861 tgaatgtcat tcaggcaaaa atggctacaa caaagcgcac tataagcttg accggtaaag 319921 ccggtatcta tataaatatt cgctaaataa gcatataatg aatatataat ttcattcctt 319981 aggaggattt cgccgaagat gaacgctaaa cgagccatcc cagtaagaga aagaaatatc 320041 gtcctgatcg gattcatggg tgtaggaaaa acaacaatcg gccaattggt cgctaaaaaa 320101 ttatatagag attttattga tattgaccag cagatcgaaa aggatttcaa tatgtcaatt 320161 cctgagatat ttgagaaaaa gggagaagac tttttccgga aaacggagaa ggaatatatt 320221 ttagacatct gccatcataa acgattcaaa atcgtatctc tgggcggggg atcttttaaa 320281 caagaagaaa tcagaaattg ctgtctggaa aactgtctcg tgcttcatct ggacctgtca 320341 tgggagaact ggaagcagcg cgcggattta ttgatcgaaa gccgccctgt actgcataac 320401 cgttcaatgg atgaaatgga acagctgttt aacgaaagaa aagtcattta tgacaagcac 320461 aattcaaaag tggcaacaga caacctttcc ccggaagagg ttgccgatta cattgttgag 320521 acattaaaaa ttggctggga tctttatcag ccgatgtaaa aagccgtgcg cagcgcacgg 320581 ctttttttat cgttttatcc cttgtatcaa aatcgctttt aaacaaaagg agatgggctg 320641 tccgttttgg ttcaatgtaa tacagaacgt gtcgcgtgct tcgtctgatg cgtgattcaa 320701 gtgggtaatg atttgttttt ctcggtcagc gggggttccg cctcgtttga tccagctatc 320761 gtattgaatc ggcaagttcc acttttggat gtcttgatag gccagttgat tggcgctgaa 320821 catcgcctgc cattctgata atgagctttc acgaacatgg gaagggtctc gaagccggtt 320881 caaatgattg acaaactcat caagaacggg atcttcaggc gcgtaatgat caactaagag 320941 aaaacgtccg tcctgtttta gtacgcgtgc aacctctctg acagctttgc ggacatctga 321001 aaaatggtgg gctgcgtatc ggcaggtgat gatgtcaaat gaatcgtcgg ggaaggggag 321061 tgactctgcc gttccttgct gaaagcgtac gttttcaact cctttttctt gcgcgaagga 321121 ggacgcaacc tcaaccatct ctttcgttgc atcaacaccg atgcactcct gtacataagg 321181 agaaaatgcc agcgccgtat ggccggcgcc cgctcctata tccagcactc gatgctctgc 321241 ccggcattcc gctgttttga tcatcaaccc caaatcttcc ccctcggcaa ataccttttc 321301 atcccgatac atctcggcgt ttttagaaaa cggtgtttca tttgtcattt gaaccagctc 321361 cttcttttcg taaatgatga tatggattat gttagcaatt tctgttatga ttcgtccaag 321421 atataaaaat gatgaaaatg ataggttcaa cctatggagg ctgaaatgga tattaaagtg 321481 atggaatatg cagcggaaat tgcccggcgc caaagcttta caaaggcggc ggaacatctt 321541 catatcgcac agccgtctct cagccagcaa atcaaaaagc ttgaggctga gctggggctt 321601 accctttttc acagatccca tggctctgtt acactgacac ctcacggcag gcgtttcatt 321661 gaaaaagccg aggacatcat tcgttccaga gatgatttgc ttcgggaaat gcaggagcga 321721 tcacagggaa tcggtcataa attatccatc gggattcctg ctgtaacagg gagatatctc 321781 tttcctccgc tgctgaagca gtttttggcg cgctatcctc atgtggaggt tcagcttgtt 321841 gaaaaagatc cggtttcatt agagaagatg acggcaaagg gagaagttga cctttctgtt 321901 ttatccttgc ccatcgagga tgaacggctc tccattacac ccttgctcac ggaaccggtt 321961 gttctcgcgg tgccgaagga aaaacaaagg tggatgccgc cggaattggt cgcgctgatt 322021 gagaaagcgc tggaagaaga tgagggacgc cagccgtgtg tgccgattga catggtaagg 322081 aacgtgccct ttattctgtt aaaagaaggc ttcggctttc gcaggacagt tctcgatctc 322141 tgtgcggaaa gcggctttaa gccgaatgct gcctttaaga cgagccatat tgaaaccgcc 322201 caatctcttg tggctaacgg attaggtgtg acaatggcac cgaatatggt cagaagggat 322261 aaagatccgg gtgtgatcta tttatcgatt caatccgcgc catcacgaac cctcgtcttt 322321 gtctttttaa agaaccgcta tgtcagtctg acggcccagg cctttatgga actaagccgg 322381 gaaagtctta aacaaacgtt tgatgaaggc tgtctgggaa acaaagatga aaatatttag 322441 aaaacaaaga cgaaacgtgg tagtatagga atacaaacta aatcttataa aacaaagggg 322501 aataatcgga aatgcaacta ttcgatctgc cgctcgacca attgcaaaca tataagcctg 322561 aaaaaacagc accgaaagat ttttctgagt tttggaaatt gtctttggag gaacttgcaa 322621 aagtccaagc agaacctgat ttacagccgg ttgactatcc tgctgacgga gtaaaagtgt 322681 accgtctcac atataaaagc ttcggaaacg cccgcattac cggatggtac gcggtgcctg 322741 acaaggaagg cccgcatccg gcgatcgtga aatatcatgg ctacaatgca agctatgatg 322801 gtgagattca tgaaatggta aactgggcac tccatggcta cgccacattc ggcatgcttg 322861 tccgcggcca gcagagcagc gaggatacga gtatttcacc gcacggtcac gctttgggct 322921 ggatgacgaa aggaattctt gataaagata catactatta ccgcggtgtt tatttggacg 322981 ccgtccgcgc gcttgaggtc atcagcagct tcgacgaggt tgacgaaaca aggatcggtg 323041 tgacaggagg aagccaaggc ggaggtttaa ccattgccgc agcagcgctg tcagacattc 323101 caaaagccgc ggttgccgat tatccttatt taagcaactt cgaacgggcc attgatgtgg 323161 cgcttgaaca gccgtacctt gaaatcaatt ccttcttcag aagaaatggc agcccggaaa 323221 cagaagtgca ggcgatgaag acactttcat atttcgatat tatgaatctc gctgaccgag 323281 tgaaggtgcc tgtcctgatg tcaatcggcc tgattgacaa ggtcacgccg ccgtccaccg 323341 tgtttgccgc ctacaatcat ttggaaacaa agaaagagct gaaggtgtac cgctacttcg 323401 gacatgagta tatccctgct tttcaaactg aaaaacttgc tttctttaag cagcatctta 323461 aaggctgata aatgtgaaaa gccgccgcat atcatcaggc ggtttttttc tgcaaactgc 323521 cggaatgaga acagactgga gacgaataga tatgaaacaa agaatcattg atgaattaaa 323581 acggatcgag cagtcatacg gagtcaaaat cgtgtatgcc gtcgagtcag gaagccgcgc 323641 atggggattt ccctcgcagg atagtgatta cgacgtccgc tttatttatg ttccgaaaaa 323701 ggagtggtac ttttcaattg agcaggagcg tgatgtcatt gaggaaccga ttcacgattt 323761 gctggatatc agcggctggg agctgagaaa aacgcttcgg cttttcaaaa agtcaaaccc 323821 tccgctactc gaatggctgt cctcagacat tgtgtattat gaagcattta cgaccgcaga 323881 gcagttaaga aaactccgca cggaggcatt taagcctgaa gcaagcgtgt atcactatat 323941 caatatggcg agaaggaacg tcaaggatta tctacaagga caagaggtca aaattaaaaa 324001 gtacttctac gttcttcggc ctattttggc ctgccaatgg attgaaaagc acggaaccat 324061 accgccaatg gactttactg ttttgatgaa tgaacttgtt gctgaacccg agctgaaggc 324121 tgaaatggaa accttgcttg aacggaaaag aagaggggaa gagcttgacc tcgaagcaag 324181 aatcgatgtt attcaccaat tcattgaaac ggaaatcgaa agaatcatgg aagcggcaaa 324241 agaactgaag gcagagaaaa aagatatgac atctgaattg aaccgtttgc ttttgaatac 324301 ggttgaagaa gtgtggaagg atggaggaag ctgatgtttt ttgtcgcttc cttttctcct 324361 ttattcgaca gaatcccccc ccgactttct aactatctga ttgtggcaaa cccacaaaaa 324421 taatcagaat ctttgtattt tgagaatatt gtgaacgctg gttttgtcca tttacaataa 324481 actcatacaa atacttctta gattgcgggg tgttgaggtt ggaagtgatc acaagagatt 324541 ttttcttatt tttatccaaa agcggctttc tcaataaaat ggcgaggaac tggggaagtc 324601 gggtagcagc gggtaaaatt atcggcggga atgactttaa cagttcaatc ccgaccattc 324661 gacagcttaa cagccaaggc ttgtcagtta ctgtcgatca tttaggcgag tttgtgaaca 324721 gcgccgaggt cgcacgggag cgtacggaag agtgcattca aaccattgcg accatcgcgg 324781 atcaggagct gaactcacac gtttctttaa aaatgacgtc tttaggtttg gatatagata 324841 tggatttggt gtatgaaaat atgacaaaaa tccttcagac ggccgagaaa cataaaatca 324901 tggtcaccat tgacatggag gacgaagtca gatgccagaa aacgcttgat attttcaaag 324961 atttcagaaa gaaatacgag catgtgagca cagtgctgca agcctatctg taccggacgg 325021 aaaaagacat tgacgatttg gattctttaa acccgttcct tcgccttgta aaaggagctt 325081 ataaagaatc agaaaaagta gctttcccgg agaaaagcga tgtcgatgaa aattacaaaa 325141 aaatcatccg aaagcagctc ttaaacggtc actatacagc gattgccaca catgacgaca 325201 aaatgatcga ctttacaaag cagcttgcca aggaacatgg cattgccaat gacaagtttg 325261 aatttcagat gctgtacggc atgcggtcgc aaacccagct cagcctcgta aaagaaggtt 325321 ataacatgag agtctacctg ccatacggcg aggattggta cggctacttt atgagacgcc 325381 ttgcagaacg tccgtcaaac attgcatttg ctttcaaagg aatgacaaag aagtaaaaaa 325441 ggagagatta tcatgacaac accttacaaa cacgagccat tcacaaattt ccaagatcaa 325501 aacaacgtgg aagcgtttaa aaaagcgctt gcgacagtaa gcgaatattt aggaaaagac 325561 tatccgcttg tcattaacgg cgagagagtg gaaacggaag cgaaaatcgt ttcaatcaac 325621 ccagctgata aagaagaagt cgtcggccga gtgtcaaaag cgtctcaaga gcacgctgag 325681 caagcgattc aagcggctgc aaaagcattt gaagagtgga gatacacgtc tcctgaagag 325741 agagcggctg tcctgttccg cgctgctgcc aaagtccgca gaagaaaaca tgaattctca 325801 gctttgcttg tgaaagaagc aggaaagcct tggaacgagg cggatgccga tacggctgaa 325861 gcgattgact tcatggagta ttatgcacgc caaatgatcg aactggcaaa aggcaaaccg 325921 gtcaacagcc gtgaaggcga gaaaaaccaa tatgtataca cgccgactgg agtgacagtc 325981 gttatcccgc cttggaactt cttgtttgcg atcatggcag gcacaacagt ggcgccgatc 326041 gttactggaa acacagtggt tctgaaacct gcgagtgcta cacctgttat tgcagcaaaa 326101 tttgttgagg tgcttgaaga gtccggattg ccaaaaggcg tagtcaactt tgttccggga 326161 agcggagcgg aagtaggcga ctatcttgtt gaccatccga aaacaagcct tatcacattt 326221 acgggatcaa gagaagttgg tacgagaatt ttcgaacgcg cggcgaaggt tcagccgggc 326281 cagcagcatt taaagcgtgt catcgctgaa atgggcggta aagatacggt tgttgttgat 326341 gaggatgcgg acattgaatt agcggctcaa tcgatcttta cttcagcatt cggctttgcg 326401 ggacaaaaat gctctgcagg ttcacgtgca gtagttcatg aaaaagtgta tgatcaagta 326461 ttagagcgtg tcattgaaat tacggaatca aaagtaacag ctaaacctga cagtgcagat 326521 gtttatatgg gacctgtcat tgaccaaggt tcttatgata aaattatgag ctatattgag 326581 atcggaaaac aggaagggcg tttagtaagc ggcggtactg gtgatgattc gaaaggatac 326641 ttcatcaaac cgacgatctt cgctgacctt gatccgaaag caagactcat gcaggaagaa 326701 attttcggac ctgtcgttgc attttgtaaa gtgtcagact ttgatgaagc tttagaagtg 326761 gcaaacaata ctgaatatgg tttgacaggc gcggttatca caaacaaccg caagcacatc 326821 gagcgtgcga aacaggaatt ccatgtcgga aacctatact tcaaccgcaa ctgtacaggt 326881 gctatcgtcg gctaccatcc gtttggcggc ttcaaaatgt cgggaacgga ttcaaaagca 326941 ggcgggccgg attacttggc tctgcatatg caagcaaaaa caatcagtga aatgttctaa 327001 gcgggactaa atgggcatcc tccctgcggg ggtgtccatt tcatccatat actataaaaa 327061 agaggaggaa gtgccataga aaacacacag ctgattattt cgatttgtat ttatatggcg 327121 ggaatgctgc taatcggcta ctttgcttac aagcgtacgt cgaatctgac ggattatatg 327181 ctgggaggac gctctttggg tccggcagta accgctctca gtgccggcgc tgccgatatg 327241 agcggctggc tgctaatggg gcttccgggc gccatgtttt ctactggtct gagcggcgct 327301 tggatcgtca tcggactttg ccttggagcg tgggcgaact ggctttacgt cgcaccacgg 327361 ctgagaacct atactgaaaa agcggggaat tctattacaa ttcccggatt cctggaaaat 327421 cgcttcggag atcaaacaaa gcttctcaga ctgttttcgg gaattgtcat tttagtcttt 327481 ttcacgtttt atgtatcgtc cggaatggtg tccggcggcg tcttattcaa cagcatcttg 327541 gggatggatt atcacaccgg cctgtggatt gtgacgggtg ttgttgtggc atataccctg 327601 tttggcggct ttttggcagt cagctggaca gattttgttc aggggattat tatgtttgcc 327661 gcactcattc ttgtgccgat cgttacgttt ttccacacgg gaggagcagg tgatacagtt 327721 gctgaaatcc gctctgtaga tcctgatatg tttaatattt tcaaaggaac gagcgtcctt 327781 ggcattattt ctttgtttgc ctgggggctg ggatactttg gccagccgca tattattgtg 327841 cgttttatgg cgataacgtc tgtcaaagag atcaaaagag cgcgcagaat tgggatgggc 327901 tggatgattt tgtctgcagt aggcgcagtg ctgaccggtt tgggcggaat cgcttattac 327961 catcagcgcg gcatgacact gaaggaccca gagacgattt ttattcaatt agggaatatc 328021 ttgttccatc cgattatcac gggttttctg atttcagcga ttttggccgc gattatgagt 328081 acaatttctt cccagctgct tgtgacatca agctctctgg tagaagattt gtataagtcg 328141 atgttcagac gctcagcttc agataaagaa ctggtgtttt taggccgact ggctgttctg 328201 gctgtttcaa ttgtcgcgtt ggttctggct tgggagaaaa ataacaccat ccttggattg 328261 gtcagctacg cgtgggcggg cttcggtgca tcattcgggc cagttgtact gctcagtctg 328321 ttttggaaac gaatgaccaa atggggggca ctcgccggca tgattgtggg agcagcgact 328381 gtaatcattt gggcgaatgc cggtctttcg gactttctgt atgaaatgat acctggtttt 328441 gctgcgagtc tattatctgt cttttttgtc agcatattga cgcaggctcc gtcacaagct 328501 gtcacagacc agttcaacga ctaccaagat acaatgtcgc aataaagatc gaaaggagga 328561 ggaaggggct gtcccttttt cctcttttct ccttttaagc ggccattttt ttcttttgga 328621 aacaaacgta tttttttcta tacaaaaaga ccccgtatgg atatgattaa agtaaaaaaa 328681 gtataggaga aaaaggtatg gaagagcttt tagagagagt tttttcattt tcagatgttg 328741 ataagctaat tgattttatt agctatgaac tgcaaaagcc agtgatactg gaaagcgcgg 328801 atttcttttt gttagcctat aattcttact atattaacca ttttgattct gccaaccagc 328861 agactatttt ttcgaaaaag tgtccggtcc agatttttga gaggtttctg aaggacggaa 328921 ttattgaaaa attgaaaaca gagcctgagc cttttcgcgt caataaaatt gaaagcattg 328981 ggttaaacca gagggtggtc gtgagtgcaa agcacaaagg ggaagtcatg ggctacatct 329041 ggattcagga gctggaccaa aatctgacgg atgaagagct cgactttttg tacgagacct 329101 ccttccatgt cgggaaaatc atttataaaa cgaataaatt gaaacaggaa aaggaagaaa 329161 aagcagagga tctcatcaaa cgggcgatct atcagcaatt tacctctgag aaggaactca 329221 gacgggaagc tgaaaggatc aacaccgtgc tgccttccat gttttcagtt gttatcctgc 329281 acgccgcaaa tggggatggg gaagcggttg aggatttaaa ggaaaatatc aggtcgtacc 329341 tgaatttacg ggataaggtc agtcatgtct taacgatcga atcaaacatt gtcatcgtcg 329401 tagcgagttt ttcccaaaaa agctccgtct cctcagcagc ttctgagttt attaacaagc 329461 tgttaacaca ttttcacttt caaaaaatac ctacccctat ttatatcggt atcggaaacg 329521 aatataatca cctattaaaa cttggcaaga gctacacaga agcacttgaa gtcatcaaag 329581 ccgcagaaat caccggcaat caggaaaaca ttccatatga atatgccaaa ctcggcattt 329641 accgctattt agaaagcatc gaacagaaaa atgaattttt agaatacgag aataaagatt 329701 tagctttatt aaaagcaaaa gacgaagaaa gcagcactga gctgctcaaa accttggaaa 329761 tctatctcct caacaactgc aaaacaaaac cagcggcaga acagctgttt attcaccaaa 329821 atacattgaa ttaccgcatc aaacagatta ctgagatgac gtcgatcgat ttaagcgatt 329881 tcagaacgcg gtgccagctc tatctcgatt tgatgctgat gaaaaagaaa taaaaaagaa 329941 accagtactt gtactggttt cgtcttcact taaaatcctc tgtaaacata cggatcatca 330001 ggttttttaa tggtattcca gtcagttact ttgacgacag ggagagttga cttgaatggc 330061 tggtaatatt ctgaggccag agtgccctta atgtgaatcc attcatcatc cttgatgtcc 330121 atgtccttcg gaaattccac aagcatcccg tacacgccgg aatcagcgat acagtgaatg 330181 atgccaaacc ttaatacgaa cagctgattt ttgttaattg cgtttccttt gtaagcaaat 330241 ccatgaaatt ctatcgtccg tccgagaaat tcacccggat agttatagat ggtttccatt 330301 ccttttagga aatcgtcatc ggtcagagaa atctcttttt tgctggaata cttattaaac 330361 agctgtttca tttgtttgtc atagctgtct tgcgcgtaat aaaggctggc atcaggccgc 330421 aaatactgtg tttgggagta gtgatctccg ctctccatcg ccttaaacga gaaccctttt 330481 gttttgacta tggatgagtc aagcgttgca atcgggaaga agatgcctga caccaaagga 330541 aaaagaaaaa caacataaat caaataacgc tgataaaatg gcttgttttg ttcatggtca 330601 tgctcgtgat catggccgca cccgcaatca tggtcatggt gatgtccgct tttttcaggc 330661 gacttgataa atagatatgc ttggacggcg gtcagaatgg ccagcaggaa gatcgcaata 330721 aaggaaagat aggcatattt catattgata tattttgtta gatttcctga ggcatgcaga 330781 tgataaaaga aaaacgtaaa tcccatcagc accaataaac gaaacatcca atcacccctt 330841 taccagtagt gatcccgcta aaacaatcac gacaatgtat gtaatcagca ggaaaacaaa 330901 tcgttttttg aaggccgcaa gcatcatcaa tagattctta atatccacca ttgcaccaaa 330961 gacgagaaag gcgattaacg atcctaatga aaacgtgctg ctgaaggaag acgcgatgaa 331021 cgcatcaact tctgaacaaa gcgacaggac aaacgccaga cccatcatca cgagggaaga 331081 ggatacatca ttctgcccga tcgcaagcag agtggatgtt ttgacatacg tctgcatagc 331141 ggctgcgata aaggcgccga tgattaaata tttccccacg gagaaaaatt catcaatggc 331201 atgccgcaag gtcccgccca gtttttggag caaggtgccg tgatgatgat ggtggtgccc 331261 gggttcatca ggctttaaaa gctggttatc cttaaattga taggataaga tgaccccgat 331321 gatcagcgaa acggcgagag ccagtccgcc tctgtaaaag accacgctcc atctattccc 331381 gaacgcaata taagtagaaa ataaaacgat aggattaatg ataggcgcgg tcagcatgaa 331441 agcaacgccc gcatgcagag gaactccctt taacagaagc cgcctcgtaa tcgggatgat 331501 gccgcattcg caggcgggaa ataaaacgcc ggccagcgca ccgaataaaa cggcgagaaa 331561 acggtttttc ggcatgattc ttgcaatcat ttcttcagaa acaaacattt gaatgattcc 331621 ggaaagtatg acgccaatca gaataaacgg aatggcttct attaaaatgc tgataaaaat 331681 agaattcagc tgaagaaaag atgattgtgc tgtcacaata aaacctccgc tcatgttaag 331741 ctgcctttct tatgatacca gaaaaaaagg cactgcttgt ttgacggagg aggggaaagg 331801 atcgtttcac tttggttagg attccaaaaa gccgagtagg atactgcctg tttctgcagc 331861 ttcttttccg agccaaatca ggtgtcccca tgagtgaagc aaacagagaa cagcgccacg 331921 aatgtgctct tttgcatgat gtgcatgtga caagtcaacc aatccgtcat aaacactttg 331981 cataatcagc acgggacata tgatggcttg caggtctttt aaagagacag cggcggtttg 332041 tgacaagtca atcagaaatc cttcacccga gcgctgccgg ctgttcattt tccgaaatgc 332101 ttctatgtct ttttcattca tcaaggactt gattcgctga aacggaagcg tgctgaattg 332161 ggggctcata gctcgaaaca tcaaacgcgg gaaagcgtta ttcaaggaag aaatcagctt 332221 ccatatccac ttttccaccg gcgggcggaa gagaatttcc cccaatttat attcagtgtc 332281 ttttggggtg agccactctt tggtgactgc ggattgcagg gtcaatgtat ttactctttc 332341 cggataatgt gaggcaaagc atatgccgct cggccctcct gctgagatgg cgatcacatg 332401 gacactctcg atttgtagat gatctaataa tttcacatag aaacggcagg cattggcaag 332461 actttttcca atttcttttg acgtccgtcc atagccaggc cttgaaggcg taatgatgga 332521 atacccttgt tcaatcaacg ctgtgtatcc gaattcctcg taacaatttg aatgcccgcc 332581 atgcatgaca aggatcggag ttcccttgcc tgtcacagaa tattctagtg taccgccatc 332641 gaaggtgatc gtttcaactc gtcttttcat ctgtttcacc caattggttt ttgcctatta 332701 tagagttttc agcaattgac cacaaggtag aagaaatgaa taaacaaagg cccttgaaat 332761 atgatatact ttgtattgat attcattctc aattaaaact ttgatataga tgtgaacggg 332821 aggcaggacg gatggctgag aatcaagagg tatatgacgt tacgattata ggcggggggc 332881 cgatcgggct gtttactgct ttttactgcg ggatgcggga gctgaaaaca aaggtaatcg 332941 aatttttgcc gaagctcgga gggaaggtgt ctttattctt tcctgagaaa atcattcgcg 333001 atatcggcgg cataccgggg attgcgggaa agcagctgat cgagcagctg aaggagcagg 333061 cggcaacgtt tgatcctgat atcgtattga atcagcgtgt gaccgggttt gaacgcctag 333121 atgacggcac cattgttctg acgggttctg aagggaaaaa gcactataca agaactgtga 333181 ttttggcttg cggcatgggt acacttgagg tcaatgagtt tgacagcgag gatgcggccc 333241 gatatgcggg caaaaatctt cattatggag tggagaagct cgatgcgttt aaagggaaac 333301 gcgtggtgat atcaggcggc ggagatactg cggtcgattg ggctaatgag cttgaaccga 333361 ttgcggcgtc tgtgactgtc gttcatcggc gtgaggaatt cggcggaatg gaaagcagcg 333421 tgacgaaaat gaagcaatca tcggtgcggg tgcttacgcc ttatcggctg gagcagttga 333481 acggagatga agagggcatc aaaagcgtga ccgtttgtca tactgagtct ggccagagga 333541 aagacataga aattgatgag ctgatcatta atcatgggtt caaaattgat ctcgggccga 333601 tgatggagtg ggggctggag attgaagaag gaagggtgaa agctgacaga catatgcgaa 333661 cgaatcttcc gggcgtgttt gtggcgggcg acgcggcttt ttatgaaagc aagctgagat 333721 tgattgccgg cggatttacg gaaggcccga cagcggtcaa cagtgccaag gcttatctgg 333781 accctaaggc cgagaatatg gcgatgtatt ccacccatca taaaaaattg gtgcataaat 333841 aaaacagccc ttgaggaaaa gggctgcttg ccatcaggtg tgaaggagtt ttttctctgc 333901 atgttgattg tggatgaaag ctagcaattc atcctgttct tgtacggctg tgaatccata 333961 aatgccggca gctgagtcat cgcctatgca gacgatagga gggcggcttg ctgacggttc 334021 cggcaaaatg ccaatttgtt cgccaccatt gatcaattgc tgaacggaca gcttgtttgg 334081 gcaaatgacc atgtgcagcg gggattcact gatggtacgc tgaatcatgt gggtgaaccg 334141 gtcatctatg acgttttcat gagtgatata aaacgaacag gattcatgct tttgcatgtt 334201 ttccactgca tggcggctcc cgacaacaag acgtttctct gaatcaggct gaatggcggt 334261 gacaagaaag ccccgtttct caagctctgt ctttgcttgc tcagatgctg cactcagttt 334321 ggctgtcagc tggcggatgt cgattttctg agaagccagt gctctgaaaa attcacaaac 334381 cgcccggcgc gatgtgaaaa aaacgtcttc aaaggtgcca atctttcgaa gaatttcttc 334441 attgacaggc atgttttcgg tccgccattt cggccactcg atgagatcgg cgccggaatc 334501 gcgcagcttg tctgcaagcg ggtcttcatc ttcgccatga gtcacaacca tcaaatgccg 334561 tccgatgagc ggtttgcttt caaaccagct gtgtgtttga aagttgacga tgtctccgat 334621 gacgataatc gcagggtttg taatctggtg ttcctgcact ttttgctgaa tgttctcaag 334681 tgttcctttc acactccgct ggcggcccca cgttccccat tggatgacaa tgacagggac 334741 agaaggcgat ttcccgtatg aaataagctg ctggcaaata taagacaagt tcttgacacc 334801 catgtaaaaa acaagggttt gaacgcttcg ggccagccct tcccagtcaa ggttcggcgt 334861 gccttttaat gatttatcat gcgctgtaat catggcaaaa gacgatgcaa aatcccgatg 334921 cgtgacgggg atgcccgcat atagcggcgc tgcaattcca gaggtgattc ccggcaccat 334981 ttcatagcga atgccgtgct catgaagagc atctgcttcc tcgccgactc tgccgaatac 335041 gctcggatct ccgcccttca agcgaacgac ggttaaccca tttaatgctt tttcaaccag 335101 cagggcgtta atttcttttt gtttcataaa atggcggttt ggcagttttc cgcaataaat 335161 aaactggcag tccggtgatg caaattcgag cagcttcggg ttggcgagcc ggtcatataa 335221 aatcacatct gcttccttga gcgcctgttt tcctttgatg gtgagcaggc ctgggtcgcc 335281 gggtccggct cccacgaaat atacgattcc gttcttcatg atcatgtcat ccttccgtca 335341 ctgtaaaaaa tgaaggacca ctagaaaagt gatccggtct tttgatcaat atacgagata 335401 aacatgttct ccttcgatca gcgtttcata tgttttgacg catccgtggt caggttcttg 335461 gacgattccg tcttctaagg aaattttcca gtcgtgcatc gggcagaaaa catattgacc 335521 gctgacgatg ccttctgcca ggacgccgcc cttatgcgga cagcggtttt caatggcgcg 335581 gatgcttccg tctgaaagct tgaaaaccgc gagctcctta tcttcaatat acactgtttt 335641 gcctaattgt tcaggcaatt cttcaatttt tccgatacat acttttgtta cgtctttgtt 335701 taccatgtcc attcctcctc aatgatagtt tttgtcatta tgatgtggtc acgacatttt 335761 caaataattc tttagaggtt tgtttatcct ctaaaaagtc tttccacgga tccttgtgga 335821 cagagagtgt ttcattcatt cggccgttca gctcctgccg cttttccgga tcgtttaaca 335881 cggattggac atgggataaa ccgacgcgct caagccatgc ggacgtacgc tccagatagt 335941 ttgcggtttc cctgtaatat tgcaggtaag cgcccgcgta ttctaagact tcttcatttg 336001 ttttcacctt catcagcaaa tcgccggcac gcaaatgggt tccgccgttt ccgccgacat 336061 aaagctccca gcctccgtcg atgccgacaa cgccaaggtc cttaatgccg gattccgcac 336121 agtttcgcgg gcaggcagac acggccattt tgactttgtg aggcgtgttc agcccttcga 336181 attttttctc aagcgcaatg cccagtgcca tggagtcttg tgtgccgaag cggcagaatt 336241 gctcgcctac acatgttttc actgtgcgga gcgtttttcc gtacgcgtag cccgatggca 336301 tatcaagatc ttcccatacc ttcggaaggt cttctttttt cacgccgata agatcaattc 336361 gctggccgcc tgtcattttc acgagcggga tctcatattt gtcaacgaca tcggcgatct 336421 tgcgcaaatc tgtggagttg gtcacgccgc cgtacatccg aggaacgact gagtatgttc 336481 cgtctttttg aatattggcg tgcattcgtt cattaacaaa gcgggatgtc cggtcatcct 336541 cgtatttggt tggattgatc atgcctaagt agtagttcag agcgggtcgg catttagaac 336601 agccttctgg cgttttccag ccgagcacat tcatgacttc tcttgtatgt gacagccctt 336661 tggctttgat ttcttctacg acttcatctc tcgacaatgt ggtgcagccg caaatggctt 336721 ctttttgcgc tgacgcatca aagtctgatc cgagcgtatg ctggaggatt tcttctacga 336781 gcggcttaca gcctccgcat gagcgggatg cgccggtgca tgctttgatt tcgtccgttg 336841 acgagcagcc cttttcctgt atggcttgaa taatcgcacc ttttgacacg ccgttacagc 336901 cgcagatgat ttcatcgtcg ctcatcgctg cggttatgct tgtgcctgct tcctggctga 336961 ggggctgtaa gattgatatt ttagaggttt cagagatatc ggcttctttt tgaatcatag 337021 aaaacaggcg attgccttcg ctgctgtcgc cgaataaaac agcaccgaca atttgattgc 337081 ctctcaggac aattttttta tagatgccgt cctgctcatc gaagacttta atcgcttttt 337141 tctcctctga ttcgttaaag tcaccggcag agaagacctc gacgcctgat acctttaact 337201 gtgtggagag aacggagccc tcatacggtt ttgtttcgat gccgcacata tgctttgcca 337261 gcacttttgc ctgttcatac agcggcgcca caagcccgta ggcgattcct cggtgctcgg 337321 cacattcgcc gaccgcgtaa atgtgcggga tttcagtctg catataatcg ttgacgatga 337381 tgccgcggtt aaccggaatg ccgctctcgg ccccgagcgt tgtatttggg cggatgccga 337441 cagccatgac gactaaatca gcttcaatgc ttgtgccatc cttgaatcgg aggccttcga 337501 cacggtcgtc accgacaatt tcttctgttt gcttttcaag taaaaaggtc ataccttgtt 337561 tttctaactc gttttgcagc aggcgtcctg ccgttgcatc aagctggcgc tccatcagga 337621 atggggcaag gtggatgacg gacacgtcca tgccgagatt cagcagtccg cgagctgctt 337681 ccaaaccaag tagtcctccg ccgatgacgg cagctttttt atattgtttt gacgcggcga 337741 gcattgtgtc tgtatctttt atgtcccgga aagctgtgac gccttttttg tctgcgcccg 337801 gaatcggaag gataaaaggg accgatcctg tcgccaggat caattcatcg taaggctgga 337861 ttctgtctgc atctgtgatg actgttttgt tttccgtgtc cactttgatg actgtttcat 337921 ttgtatacaa ttgaatgttg ttttcttcgt accagtccca atcgtttaac gtaatatctt 337981 taatatctgt atcgccttga agcacttttg acaaaaggat tcggttgtaa ttgggatgcg 338041 gttcggcacc gaaaattgtg atctgaaact cgtctttagc aacactcagt atctcttcaa 338101 tggcccttac cccggccatt ccattaccaa caagaactag ctgttttttt cccatcagat 338161 gatccgctcc ttatcaaatg ttttttccag cgtagcacag caaaaaggaa tatttaagat 338221 acatgttata aaatgtaaca aaatatacga aaagttctaa aaattttatg aaaaatttaa 338281 ataggtatga ttcggacggc gcatacctta aaaccgggca ttttacaggc tggatctaag 338341 gcttccccga ttaaatcatt cacattttga gcgtctgccc aatggatggg aacaaaaacg 338401 gtatcttttc tgatttgttc tgataatttg ctgcggacgg tgatgcttcc ccgcggcgat 338461 tctattttta ccagtacacg gtcctcgata ttgtaggtcg ctgctgtttg cggatggatc 338521 tccataaacg attcaaaatg tctcgcggca agggcggcgc tttttcttgt ttggacgcct 338581 gttaagtagt gagacatgac tctgcctgtc gttaaataaa gcggataatc ggctgtcggc 338641 ttctcttttg gaacaggtgg ttcgtttgga atcacactta atgccgcttt ttgatccgga 338701 tgagcaaatg attctgtaaa caagcgccca gttccgggat gatcagattc cggacacggc 338761 caatgaatgc cgccttcacg tctgagcctg ccgtatgaga tgcctgaata atcggcaatc 338821 ccgcctcggc tcgcttctct caattcattg aaaatatcct ccgctgacgt ataagaaaag 338881 tagcggccct tgccgagagc ggatgcgaga tcacaaatga tctgccaatc atgctttgct 338941 tcgccggggc atggccggct tgcttctctt aatgtcacgc gtccttctac atttgtcatg 339001 gtgccttcat cttctaagta agaggaggca ggtaaaatca catctgcgta tttcgcagtc 339061 tcagaaataa acaaatcgat tgcgacaaag aatgtcagtc ttcttaaagc ctttttcacg 339121 agatttgcat ttggactgga aacagcaggg ttggagcaca tgaggaacag tcctttgatg 339181 tcgccgtcat tgattttttc catcatttca taggctgaga caccttttcg cgggagttca 339241 tcctgatgga ttccccacac tttcgcaata tgcgcccggt gttcttcgtt ttcgatagaa 339301 cggtagcctg gaagctgatc ggctttttgg ccatgctctc tggcgccttg cccgttgcct 339361 tgtccggtga tcgccccgta gcccgagtaa ggtttgccga tttttcctgt gatcagcacc 339421 atgtttaaga agcctttcac agccgctgtt ccatcggttt gctgttcaat cccgcgggct 339481 gtaaacagca tgccggacgt ttccttggca aacttcacag cagcttttct tatatccacc 339541 agcgagacac tcgtctgttc ggcgatgtca ttcaggtcca acgagtcagt atgctgcttc 339601 agctcttcga atccatttgt tcgtgattga atgaaatcct cgtttataag ctgttcgtca 339661 atgatgattt tgacgagacc gttggcaagg gcggcgtctg tgccgggttt gattttcaga 339721 tgaagatcgg cgattttcgt tgtcgctgtt tcacgaggat caatggcaat gaagtaagct 339781 ccgttttctt tcgctttttc aaaatacggc ataatcgtag gctggcattc cgcaatattg 339841 gtgccggcca gaatgatcac acgggtgtgg gggatgtctg ataaaggatt cgttaagcct 339901 ctgtccgcgc cgaatgtttg gttggctgcg gtggctgctg cggacataca aagtctcccg 339961 ttgtagtcga tgtattttgt ctgtaagcct actcgtgcga acttccctaa caaatacgcc 340021 tcttcatttg taatcgaggc gcttccgtat accgccatgg cgtcatgtcc gtgttcagtt 340081 tggatcattg tcacttggtc tttgatatga ttcagtgctt cttcccagga aacaggcata 340141 aactcgccgt ttttcttcag cagcggccgg gtgatgcggg aggagttcaa ggcatgctgg 340201 tgagcattca tgcccttgat gcatagccga ccctgtgtcg taggattatc aatcccgatc 340261 gcagtgtact ttttgcgcgt gacgatggtt tgttccacga gctgcatttt gcactgcatg 340321 ctgcaaaacg ggcattgagt gtcatatgtt ttttctgatt ggacgtcttg ctgtttatca 340381 cggaaatatc taagcagtcg ttcagtcaaa atgcctcatc ctttcttata tgcgcccgtc 340441 tctacagtcg ggttttgaat cagtgacaga tctgtttgga ggctttccag cagctgtgcc 340501 cttaggtctt cttcgaatag cacttctctg atatgaacga tcccgagacg gtctatccac 340561 tgatgaacac cttctaagta atgagccgtt tcccgataat actggatcag tcctttgatc 340621 atgccggcag tgctgtcttc gttctcagtc acgcaaaaca aagctcctga acgggcatga 340681 gttccccgga cgccgccgat gtgaatgtcc cagccagctt gtgtccgaat tgcgccgaca 340741 tcttgcaggg cggcctcggt gcagtctgtt tcacatgata agctgataga aatgggagcg 340801 ggtaagggaa gcatctcaag ttgtctttcg atttgggctg ccagctgctg aatcgatcga 340861 ttttgcccgc atgtacatgc tttgatgctt tgcagcgcgt gtcggtgttc attagtgtaa 340921 acgggcattt tcaggtcttt tttcatgttc gggagatccg caggcttgat cccggaaagc 340981 ttcagccttt ggccgtgagt gatggatacg tcgggaatgc tgtatgcctc aatgatgttg 341041 gcgatggttc ttagctgctc cgcgtttgtc cgcccgccgt acatttgcgg aatcaggatg 341101 catgtctctt cagtggctgg ctcaggctgg acaaacccag ggtacagcat ttccagatag 341161 tattgaatcg caggaacaca agtactgcat ccgttttttg ttttccagtc aagctggttc 341221 atcacttctg ccggattagt gaatggcctg cgctgaagct cagcgatgat gtcgtcttct 341281 gtaaaatcag tacagctgca aaacgaaggt gtgctggcgg gcttcgtata ttcgctgttg 341341 gtcatgtatc tcaaaaggtc ttcaacgagc ggtttgcatc ctccgcagga cccagtggct 341401 ttggtgcagt gcttgacttc ctcaacagtt gttaagctat tcgtgtgcac cgcgtcttca 341461 atcgcgcctt tcgtcactgt gttgcattgg caaatcgttt cactggaagg catggattca 341521 aataaagggc cgcttgtctc cggttcgatg atctgttttt tggcaatgga gatgtctcgt 341581 tgtttaagca ggctgtcgag aagccgctgc ttgtcacggg tgtctccgaa taaaataacg 341641 ccggccagtt tgtcatctac aaaaagcgct tttttataaa cgcctgcttg ttcgtcgtag 341701 attttgatgc tcgtcgtgcg ttcatcctct tggatctttc ctgctgacca cacatcgatt 341761 ccagctattt ttaacgccgc agatggtgct gagccttgat attcctcaca tggaacgccg 341821 caaatatgac tggcgagcgc ttttccctgc tcataaagcg gagccaccaa tccgtacacc 341881 gttccgttat gctcagcgca ttcaccaacg gcgtagatat tcggttcgct tgtctgcatg 341941 aagtcattca cgatgatccc gcggttcact ttgattccag cggatacagc caattcaata 342001 ttcggtttga cgccggccgc catcacaatc aagtctgctt ttaatgaaga gccatcttta 342061 aaatggattc ggtctgcctt cgtggcgccg gaaatggaga cggtgtcttt ctccaaaaga 342121 aaggttaggc ctttttgttc cagctctgtt tgcagcagcc gcgccgctgt ttgatcgagc 342181 tgtttttgca taatgccggc ggagtggtga atgacgctga catccatacc gagatgctgt 342241 aaacctactg cagcttccag tcctaataag ccggctccga ttaccgcagc cttttgaaag 342301 tgctgggcca tgttcatcag cgcttggcag tcttctattg tccgaaatcc atagacacct 342361 tttttgtctg ccccggggat agggagaata tgaggggagg agcctgttgc cactattaat 342421 ttgtcatacg acagagtgcg tttccgatct gtgatgacct gctgctgatc tgtatcaatc 342481 tgaataaccg tttcgcctgt gtaaagcgtg atcccgtgct tgtcgtacca atccttgctg 342541 ttcagtgtaa tatcatcgag tgacgcttca ccctgcaata cagaggataa gagaatgcga 342601 ttgtaattgg gatgcggctc gcttccgaaa atgacaatct caaacatgtg gcgattcagc 342661 tttaatactt cttcaataca gcggattccg gccatgccgt ttcccgctaa cactaatctt 342721 tgtttcttca tgtatcagac ctcctttggc gaagctcgta agttttctcc tattaaaaat 342781 tatgtcacaa tgcattgtta acgcattaaa cgtgtcacaa aaacttacac atgtcttttc 342841 cagaaaataa tggtcctata tccttgattc agaaaatgta aaataatgag ggtctagaaa 342901 ggggaatctt atgaagctgt cggaactgaa aactagcggt catccactca ctttgctctg 342961 ttccttttta tactttgatg tcagttttat gatatgggtt atgcttgggg cgctgggtgt 343021 ttatatttct caggattttg gcctgtctcc ttttgagaaa gggcttgtcg tagctgtgcc 343081 gattttatct ggatctgtgt ttcgtatcat tcttggtatt ttaacggaca gaatcggacc 343141 gaaaaaaacg gcagtgatcg ggatgctggt gacgatgatt ccgctgcttt gggggacatt 343201 cggcggccgt tccctgactg agctgtatgc catcgggatt ctgcttggcg tggcgggagc 343261 aagctttgct gtagcgctgc ctatggccag ccgctggtat ccgcctcatt tgcagggact 343321 tgcgatgggg attgccggag cggggaacag cggcacgttg tttgcaaccc tgtttggccc 343381 tcgtctggca gagcagttcg gctggcacat tgtcatggga attgcgctaa ttccattatt 343441 gatcgtcttt attctttttg tatccatggc aaaggattcc cctgcacagc cgtctcccca 343501 gccgctcaaa agctatctgc atgtgtttgg gcaaaaggaa acatggtttt tctgcctgct 343561 gtacagcgtc acatttggcg gatttgtcgg gctctcaagc tttttatcta ttttctttgt 343621 tgatcaatac cagctgtcaa aaattcacgc aggggacttc gttacattat gtgtggcggc 343681 ggggagcttt ttccggcctg tcgggggctt gatttcagat cgtgtcggcg gcacgaaagt 343741 tctttctgta ttgtttgtca tcgtggcact gtgtatggcc ggagtcagta gcctgccatc 343801 tctctcaatg gttattgttc tattgtttgt cggaatgatg gggctcggaa tgggaaacgg 343861 cgcagtattc cagctcgtgc cgcagcgctt ccgcaaagaa atcggcatgg tgacgggaat 343921 cgtcggtgcg gccggaggaa tcggagggtt tttcttgccg aacatcttag gatctctcaa 343981 acagatgaca ggcacatatg ctatcggttt tatcacgttt tcctgtatcg cgctgctggc 344041 gtttgcactt gtgcttgccg caggctatta ctggcggaaa agctggagcg cggaaagcag 344101 cccggcggat gtttaggatt ttgacggaca cgcgtttgtg cgtgtctttt ttattttctc 344161 ttgattttca acagtgaacc gatcaaaata aatagtaatt attacgattt gttagtgaga 344221 ggagttttct gaatgaatca acatacgctg ctcccgaaaa aaacggagcg tcttcaatac 344281 tttggatcgg tcagtccgat caaaggcgag aaaccagtgg aaaaagagaa aatgaaggac 344341 ctgcaaaata tcaggaagga ttattttttt gacattcagc atgtaggtgt agctaatgtg 344401 tcccatccag tcacaatcac ttctgccatg atgcctgccg agcaaacaac ggctgcgaac 344461 tttacaatga cttgtaattt gccgagaaat cagaagggga ttaacatgag ccggttaaca 344521 gagctgctgc aagtctatca tcaaaatggc tggattctct cattttcctc tcttcagcaa 344581 tttacgaaag agcttgcaga aaacatggac acatcatctg ccacagttga agtgaggttt 344641 ccgtggtttt tcgaacggaa aagcccgaag cttgagaaag cgggtttgat gcatgctgat 344701 atattcatgt ctgtcaccta tcgcaaagat cagccgttta aacagcgtgc cggcatctca 344761 gcaaaagtaa cgactctgtg cccttgctcc aaggaaatca gcgaatacag tgcccataat 344821 cagaggggaa cggtcagcat ttgggcggat attcacccgg ccgcatcgct gccaagtgat 344881 gttaaagctg atttgcttca cgccgcagaa tcaaatgctt ctgcgagact gcatccggta 344941 ttgaagcggc ctgatgaaaa agccgtgaca gaaacggcct atgaaaaccc gagatttgtt 345001 gaggatctcg cccggctgat tgctgcagat ttgtttgagc ttgaatgggt gtcagccttt 345061 gagattgaat gccgaaatga agaatcgatc catcttcacg atgcctatgc gaagctgtgt 345121 ttttcgaagg aagtggataa aatatgaaac tctcattatt cattattgca gttcttatgc 345181 cagtcatcct gctgtcagcc tgctccgatc atgcagaaga acacgcaagt atcaatacaa 345241 agaaaacggt cgaaaacata acggacgttc gaaaaacagc aaaaacaagc attgattgga 345301 caaagccttc gggcggagaa tacccggata ttaaacagaa gcatgtctgg attgatgtga 345361 atgtgaagga gcagaaggct tacatcaagg aaggaagcaa caccatctat acaatgatga 345421 tttcttctgg tcttgatcaa acaaaagatg atgctacgcc aaagggcacc ttttatgtag 345481 agcctgaacg gggagaatgg tttttctccg aaggatacca ggaaggcgca gaatactggg 345541 tatcatggaa aaatcacggt gaatttttat ttcatagtgt gccaatgact aaggatcaaa 345601 aagtcatcaa aacggaagca gaaaaactag gaacgaaagc atctcacgga tgtatcaggc 345661 tgaccattcc agatgcgaaa tgggtatatg aaaatatccc tgaacataca aaagtggtga 345721 tcagctgaat tgaaaaccgt tgacaaaaag gaaaaaagac catacaattt aaatcgtaac 345781 aattacgttt tatgataaat ggcttatcat tgtctgtgca tctgtgaaaa gcggaaaggc 345841 atcgattaag gatcttgctg tcggcaaagg caaggatttg cgatggggaa aaggattaaa 345901 cgcggttgga gtctttactg atttagaaat cgggcggcag cgagaaatga gcgcgaaaag 345961 ctgctctaca ccattgtaca tacggcgaag tattcaattt aaatcgtaat cattctattt 346021 taatggaggc actattatga aaaaaattcc ggttaccgta ctgagcggtt atctcggtgc 346081 gggaaaaaca acattgctga acagcatttt gcaaaatcgc gaaggcttga aaatagcggt 346141 tatcgtaaac gatatgagcg aggtgaacat tgacgcgggc ttggttaagc aggaaggtgg 346201 cctttccaga acagatgaaa agcttgtgga aatgtcaaat ggctgcattt gctgcacgct 346261 tcgcgaagac ttattaattg aagttgagaa gctggcaaaa gacggacggt ttgattatat 346321 cgtcatcgaa tcgacaggaa tcagcgaacc gatcccggtg gcccagactt tctcttatat 346381 cgatgaagag atgggaatcg atcttacaaa attctgtcag ctggatacga tggtgacggt 346441 tgttgatgcc aaccgttttt ggcatgatta tcagtcaggc gaaagccttc tggaccgcaa 346501 agaagcattg ggggaaaagg atgaaagaga aatcgccgac ctcttgatcg atcaaattga 346561 gttttgcgat gtactgatct taaataaatg tgatttggtc agcgagcaag agctcgaaca 346621 gcttgaaaac gttcttcgta aactgcagcc aagagccagg ttcattcgtt ccgtcaaagg 346681 aaatgtaaaa ccgcaggaga ttttgcatac agggttattt aacttcgagg aagcgagcgg 346741 atcggccggc tggattcaag agctgacggc aggccatgcg gaacacaccc cggaaacaga 346801 agaatacggt atctcttcat ttgtatataa gagacgtttg ccgtttcatt ctacacgatt 346861 ttaccgttgg ttggatcaaa tgccaaagaa cgtggtacgt gccaaaggaa tcgtctggtg 346921 cgcatctcat aacaacctcg ctttgctgat gtcgcaagca ggtccgtcgg ttacgattga 346981 gcctgtatct tattgggtgg cggcgttgcc gaagcttgag caggagcaag tcaaacagca 347041 ggagccggaa atcctggagg agtgggaccc ggagttcggc gaccgcctaa cgcagctagt 347101 ttttatcgga actgacctgg atgaagaaac gatcacgaaa gagcttgatc aatgcctgtt 347161 gactgagtat gaatttgatt ccgactggtc gctgtttgag gacccgttta aatggaagct 347221 gaatcaatag aaaaaaagcc gtcccatggg gaacggcttt ttttaatgaa acgtttgttt 347281 aaacataatg agcgtatttt ttctcaagga tattctgaaa gaccgcggca atggagcaga 347341 tggcccaata aatgagagcg gtcagaatat acatggtcat ataatcaaac tctctgcccc 347401 cgatgatttt cgcatgctgg agcaattccg gcactgtaat catcgcagcg agagaggacg 347461 ccttgatcaa gtcgagcaat acattggcaa gcggaggcag cgcaatacgt atcgattgcg 347521 gcaaaatgat gcccctcatc gtctgccaat aggaaagacc cagcgaggat gcggcttccc 347581 actgtccttt ttcgacggat gaaatggctg aacggttaat ttccgcaatg taggcggcgc 347641 tgtttaggct aaagccgatt aaagcagccg tgacagcgga aaattcaatg ccgatataag 347701 gaaacccgaa ataaaggata aacaaaatca ccaaaatcgg aacgcctcgc ataaatgaga 347761 tatagagctt cgccggccat cttaacaaag caagtttaga cattctggcg agtgatatga 347821 acaggccgat cacagttccc gcaaacatgc ttacaaaaga gatgagcagt gtataaccaa 347881 tgccttttat gacataaggg aacgattcaa tggccagctt cgtgttgaaa atatattccc 347941 actgaatgct attgatcatg gcgtccgatt acaaatcaac gtcctgaacg tcggcatcaa 348001 ttttttttga tacatctgct ttattgaaga attgtttcga cagtttagtc aaagagccat 348061 ccttgctcat ctctttcaat gcttcgttca tctttttctg aagtgccgca ttgctttttt 348121 tcatgacaag ggcctgtttg ttcggcatgt acttgatgtc aggatgaatt gtaatgttga 348181 gatccgggaa tgccgcgagc gcaagtgtct gcaggtaata gtcgtttaaa atgacgtcag 348241 tgcgtccgtt ggcaacatct tttaaatatt gctcattcgt cgcattatca taaatcactt 348301 ctttggcgcc gtattttctc gcgacctcca tgtagacggt tgtagccgcg ccagccgctt 348361 tcttcccttt taaatccttg agcgttttaa tccctgataa atcgtctttt cggacaattg 348421 ccgtgccgta tgaatattta tatggagtgg aaaatgcgaa cttctcctca cggtccttcg 348481 tcacatcgat gtcattcgcg gctgcgtcaa cctgtccgct gttcaccgct gtcagcatcc 348541 cgtcaatgcc catctccttg aactcaacct tcagccccaa gcgttttgcc gcttcacgaa 348601 caacttcaac ctcgtagccc gtcagcttat cagagccaga gtcagtatcg tgataagaag 348661 tgggatagag cgtacctgat gtagcgacta cgattttccc tttatcctta atctgctccc 348721 agcctgtatc cttggaatcg gcttcatttt tgccggaaca ggctgccaat ataagaaaga 348781 aagccattgt gaaactgaat ataacggctt tggaatgcat gaatgatttc acctatagtt 348841 cccccaatct gttaatcaac taaaaagata gcattgaaca taaggggttg caatatgttg 348901 atcgcgtttt caaaaagttc gaattgtgta tacaaaaagc atgggtgggt gtttaaaagc 348961 gtctatgaag ggaagaggtg atgaaaaaag gaattgtcca aggatgaatg ccagacgtac 349021 caaggaaacg catgtgaaag tgaaggatgc agcagacccg tcactcatct atgccaatac 349081 cggaagaaat ggtcaagagg catgaaaccg atcttcagaa taaatttaag tcttgctgat 349141 gcccctaagg catatgatat attcgatgag aaagaaaatg gaaacattta aaccataatg 349201 gggagtcaaa tgaatattta caaaccagcc ggattttgga tcagacttgg agctgcattg 349261 ttagactaca ttatagtctc cgtgccgctt ttgctgatct attggctgat tacaggaaaa 349321 gacccaaacg acagcatgtt catcagtttg gttgttctgc tgtattctat tttgctgccg 349381 atgttttggc gcggttatct tatcggaaaa aggatctgcg gaatcagaat cgtaaaaaaa 349441 gacggatcac aggtcagtct gttaacaatg tttttacggg ttattgtagc cggcctggtt 349501 tactgtataa ccttcggact cggcttgatc gccagcctga ttctgattgc cgtacgagaa 349561 gacaaacgga ccctgcatga tttaatcgcg ggaacatatg tcacttatgc gacaccaggt 349621 gaagaggaac ttaatgctga cgaagagatt agaaagagcg aataatggtt cgctcttttt 349681 atttttatgc ataaaaaata caaggcagca aaacatatga aaaataggat tggaggaata 349741 aaatggatga aacgaataac catcaacatt atcacaatgt tcattgcagc ggctgtcatt 349801 tctctgaccg gtacagctga ggccgctgaa aaacagcagc agtctcccgc aaatgttaca 349861 ctgacagatc agcaaaagaa agagattgaa caactggaag cagagattct taaaaagcgc 349921 aaagacgtga tctcaaagta tgtacaatac ggtatcctgc ctaaagaaag aggagaacac 349981 atcaaaaatc acttggacaa acactttgaa atgatgaaac aaaacggctt tgttccaaag 350041 caccatcctc atccgcataa atttgaaaaa agacattaag attttaagca tccaatggga 350101 attgggtgct tttgcgttat ttacaggtag gcaatattag ctgagctgtt ccgcgactaa 350161 catcgagttg atatgaaacg cgtttcatag cctatgatag gtttatcaaa taattcagga 350221 gtgataaaca ctatgatcca ccagcatcca gaatcttttc cgaaacattt tttgtggggc 350281 tctgcttctg cagcgtacca gattgaaggc gcttggaatg aagatggcaa aggcccttct 350341 gtttgggatg tgtttacgaa aataccgggc aaaacgttta aaggaaccaa tggcgagatt 350401 gcggttgacc attatcaccg atttaaagaa gatgtcgctc tgatggctga gatggggtta 350461 aaagcatatc gattttccgt cagctggcca cgggtttttc caaaaggaaa aggagagatc 350521 aatgaagcag gtctagcgtt ttacgatagt ctgattgatg aattgctttc tcatcacatc 350581 gagccggttc tgactttata tcactgggat ttgcctcaag cgcttatgga cgaatacggc 350641 gggtttgaat ccagaaacat catagaggat tttaatcact actgtattac tctttataaa 350701 cgttttggag acagggtgaa atattgggtt acgttaaacg aacagaacta caattttaat 350761 cacggattta ttacagccat gcatccgcct ggagtgaaag acagaaaacg attttacgaa 350821 gcaaaccata ttgcgtttct ggctaatgca aaagccatcg aatcatttag agaatatgtg 350881 cctgaaggca aaataggtcc tagctttgct tattctccgg cttacccttt atcaagtcat 350941 ccagaggata tactggcatt tgaaaacgcc gaagaattta cgaacaattg gtggcttgac 351001 atgtattgct ggggaaccta cccgcaaatt ccattccgct gcttggaaaa acagggatgg 351061 gcgccgacaa ttgaagcagg agatatggac ctgctcgcca aagggaagcc tgattttgta 351121 ggtgtcaatt attatcagac gatcacctat gaacgaaatc cgcttgatgg tgtgtcagaa 351181 gggaaaatga atacgacagg ccaaaaggga accaatcagg agacggggat acccggagtg 351241 ttcaaaacga aaaaaaatcc gcatctgaca acgagcaact gggattggac aattgaccca 351301 attgggctgc gtatcggtct tcgccgaatt acaagccgct atcagcttcc agtgtttata 351361 acagagaacg gtttgggtga atttgataaa gttgaggacg gcactgtaca ggatgattat 351421 cgaattgatt atttgcgttc gcatcttgag caatgcagac aagccatcag tgacggtgtc 351481 gatttaatcg gctattgcag ctggtcgttt actgatctgt taagctggct gaacggctac 351541 caaaaaagat acggatttgt atatgtcaat cgtgatgaag aaagcacatc cgatttaaaa 351601 cgcttgaaga aaaaaagctt ttattggtat caagatgtca tcaagacaaa cggagaaagt 351661 ttataaagag tccctgagag ttattctctc aggggttttt cattacacag aaacagcatc 351721 aataatataa gtgtcggcgt gcaaatctga catttcagcc ggcacagtcc agcatgtcaa 351781 ttgatagtct cctttaggca gatcaaagga cagtctttta gacatgatgc tttcaatatg 351841 aattccgttt tctgtgacat gaaaaggaac agtcactttt ttttcgtagg agtttactgt 351901 ttctgaactg ttcaggcgaa aaagaataaa ggcctttgta tttcgctgtg cctcaaagga 351961 aatggctccg tctgccgcag catatccttt ttcaatcgct tcgtcagtcc aatccattac 352021 aggaggtgta gaatcctttt gaaatacagt aaattgatga tatgaaatcg aaagttcttg 352081 cggcttccat gatttgatca atgtgctgtt cctcctctat gtactgttta ctgaattgtg 352141 aataaaacct ttgtgccgtc tgggtaatcg gtaagccgat gcccgaccca agagcctgct 352201 ccgcggttgt cagcgggaga aatgtattct acagaagctc cctcaccgcc ttctttgcac 352261 atggccattg gccattcatc tctgtcatac ccctttttgg aaggtacgtc ctttaatgat 352321 tgctcgcggc gttcttcagc tccgtctctg tcaatagtgc acacctctga gtgcccctca 352381 tttatcgcat ccttaatatg cttggcagtt tcgggatacc ggtcagatgg gaaggccatt 352441 gtttcatcat attctttcgt ttgagacgtt ttttgatcag ctgagaaaaa gtctcctttt 352501 atcaggccga cagctgcagc tgctatgatg acgatgacga gaagtatcgt ttttatgatg 352561 tccgtcgtga tgttcacctc ccgcttttaa aactgacaca agagtaatcc agaaagcatt 352621 tggtgtaaag gtttaaattt tatgttttac gatcagttta ttgcagaaat cgtaatttta 352681 gcagatcgaa atatttgttt tcagcaaaat acgattgcca atttacaata atgatagtaa 352741 gtcatcagcc gttttcggct tgattaatca ttttaaattg gcttatgata ccggtaagct 352801 cctcagctaa ttgagaaagt gtttcagaag ctgcggtaat ctcctccatt gcagcaaatt 352861 gctcctctgt taatgcagcc gcttgccggg tatttttagt agattcttta atgtcggccg 352921 tattggctgc aaaggaatca tttatttgat gtgcactggc tgaaatgttt gttacagatg 352981 ctgataaatc actaatctcg gcgctgattt cacctgttgc agctgcaatt tccttaaatg 353041 catctctggt gcgctggatc atggtgactc cttctgcagc ttctgttttc acatgctcaa 353101 cagatcttgc agaccggttc atatcctttt gtatttctat gatcagtttt gaaatctgcc 353161 ccgcagactg ttgagactct tctgctaatt tccgtacttc atcagcaaca acagcaaagc 353221 cttttccttg ttcaccggct ctggcagctt caatcgctgc attcagcgca agcaggtttg 353281 tctgatcagc aatttgggtg atgaccgata aaatttgctc aatttgttta gagcggccgt 353341 ctaactggtg tatgatttct ccgcttttct gaattgactg gtgaatcgca tccatttgcg 353401 cctgtacatt tgcaatttcc ttttgtccaa tgtctgcttt tgattgagcg agctgccctt 353461 tgtcagcgat agcggcagta tttgcagaaa tatcccggat gtctgctgaa gcttgtttta 353521 atgagctttc actattttca attcgggtga tctgatcttg ggctccattt gcaatctgct 353581 gtacagcttc tgtgattttt tctgaagctt gatttgtttc ctctgctccg gctgagagct 353641 gctgagaggc tgacgcaagc tgaagggctg attgttgtac ggtttgtatg gtatcgttca 353701 gcttcattct catcttatta taatagacgc ttagttctga aagctcgtca ccggttttgt 353761 ctgacacctc tattgtcata tctccgtttc cggcactttc aaaggcgctt tttaaagcgt 353821 tcagccgctt gttgattttt ctggtgaaaa ccaagacaag gatgactgat accataatga 353881 cgataacaag aacgatagcg aattgagtga aaagtgattg tgtaagtgat gctaaaatac 353941 tttgattagc tccggtatac agcatgccga tgatgttccc attttgatct tttaacggca 354001 tgtatgcagt ctgataagaa gaacctgcta catctgcttg tccgtaaaaa cgctttcctt 354061 tctttaaaac agcggcaata acttcagaag aagcctgggt gccgacggct ctttcgccat 354121 ttttcatgac attggttgca acacgagtat cgccttggaa aatggtaatg gtatcacctg 354181 tcttttcacc aagcagatca acaatatctt catttccatt gatttgtgtt tgccctttat 354241 agagcttatt gtttttcacc tgccagtcgc ctgacatgac atcatcaata taagtgctgc 354301 ttaaagcgag atcacctttc gctttttcag ttgccatttg tttcatgctt tctgtaattt 354361 ccttaagcat cacagtgcca actgatgccg aaaacaaaag aatcaccacg aaaacgaggc 354421 aaagaatttt agttcctagc ttcatcttaa atcgttttat caacataatt cctcccttta 354481 cgatttgcag gtcatattac ttatcgggtt tttgggttta aagttttatt ttagaaaaaa 354541 taaaaccggc ctgatcttca ggccggttgt gtgatgctat tcaaggtttg cgtggtgagt 354601 gaacatagtt tcagaatcga gacctttttt ctccatgagt tttaaaatca ctgcatcata 354661 gaagagcagc aaagtttgtt caaataatga tcccattggc tgaatggttt tatagcttcc 354721 gttagactgg tctttagggg aaccaggcat tctgatgatg aggtccgctt gttttccgat 354781 gcttgattcc ggattgatgg ttaaagcggc aacaattccg tgtaagcttt ttgcttttgc 354841 tgcggtatga atcaagctct ttgtctcgcc tgatcctgag ccgataataa ctagatctcc 354901 ttcggcgagc ggcggagtga gaatctcacc tactatatgg gcgttgaagc ccatgtgcat 354961 cagtctcatc gcgaaggatt ttgccatcag gccagaccgc cccgcacccg cggtgaaaat 355021 ttggtgggat gaaagaatgt gatcggcaag ctggtcagct tcttcattag aaatataagc 355081 tgctgaattg tgtaactcat tgagaatttc cgctacgtat tcagtcgttt tcatcggagt 355141 tatccttgga caatcagctg cttcattttt gaagctgttt ccgccttatc agctgcgctt 355201 gtaattccgc ccccgacaat gacaaggtca ggcttttgct ggatcacttc tggcagtgta 355261 tcaagtttga tgccgcccgc gattgcggtt tttgcgtttt ttacggtatt tttgattgtc 355321 gttaattctt cgaaagagtt tttgccctct gcttgaagat catagccagt gtggacgcag 355381 atgtagtcaa caccgagtgc gtcaatttct ttcgcacggg attcgatatc tttcacgtta 355441 atcatgtcca ctaagatttt cttcttttgt tttttggctt cttctactgc gcctttaatc 355501 gttgcatcgt ctgtagcccc taaaacggtg atgatgtcag cgcctgcttc cgacgctttc 355561 ataatttcgt agcctccggc atccatgatt ttcaggtctg caagaacctt caattgagga 355621 aatgcttctt ttatttcttt aacggctctt aggccttcat tgatgacgac cggtgttccg 355681 atttcaacta cgtcgatgta ttgttctacc tctttgacaa gctcaatggc ttccgggatg 355741 ttgacgaggt ctaatgcaag ctgtaattcc attgttgatc cactcccttt ttcgaattat 355801 tgttcattct ataggttcct tcttttgttg agaagtaggc actttgaagt caacaagtta 355861 cttggaggat actgtgagga gagacaatca gatttctttc gcttgatttt atgagtgagt 355921 ataatgaaaa aagagtctgc aaaaaagtaa gtaagtgatg atacgtatct aacatacaaa 355981 aaggttacta agggggggga ttctattgag ccggatggac gacaaaaggt ttaattgtga 356041 gaaggaatta acgcttgcag tgattggcgg taaatggaaa atgctcattt tatggcattt 356101 aggaaaagaa ggcacaaaac ggttcaatga attaaaaaca ttgattcctg atattacgca 356161 gaagatcctc gtgaatcagc tgagagagct tgagcaggat atgattgttc acagggaagt 356221 gtatccagtt gtcccgccga aggttgaata ttctctgacc ccgcacggag aaagcctcat 356281 gcctattctt gaagccatgt atgagtgggg gaaaggctat atggaattga ttgatatcga 356341 caaaaatgtc atgaaagaat cgttgtaaga cgctcttcgc aagggtgtct ttttttgcct 356401 ttttttcggt ttttgcgcgg tacacatagt catgtaaaga ttgtaaattg cattcagcaa 356461 taaaaaaaga ttgaacgcag cagtttggtt taaaaatttt tatttttctg taaataatgt 356521 ttagtggaaa tgattgcggc atcccgcaaa aaatattgct gtaaataaac tggaatcttt 356581 cggcatcccg catgaaactt ttcacccatt tttcggtgat aaaaacattt ttttcattta 356641 aactgaacgg tagaaagata aaaaatattg aaaacaatga ataaatagcc aaaattggtt 356701 tcttattagg gtggggtctt gcggtcttta tccgcttatg ttaaacgccg caatgctgac 356761 tgacggcagc ctgctttaat agcggccatc tgttttttga ttggaagcac tgctttttaa 356821 gtgtagtact ttgggctatt tcggctgtta gttcataaga attaaaagct gatatggata 356881 agaaagagaa aatgcgttgc acatgttcac tgcttataaa gattagggga ggtatgacaa 356941 tatggaaata actttttacc ctttaacgga tgcacaaaaa cgaatttggt acacagaaaa 357001 attttatcct cacacgagca tttcaaatct tgcggggatt ggtaagctgg tttcagctga 357061 tgcgattgat tatgtgcttg ttgagcaggc gattcaagag tttattcgca gaaatgacgc 357121 catgcgcctt cggttgcggc tagatgaaaa cggggagcct gttcaatata ttagcgagta 357181 tcggcctgtt gatataaaac atactgacac tactgaagat ccgaatgcga tagagtttat 357241 ttcacaatgg agccgggagg aaacgaagaa acctttgccg ctatacgatt gtgatttgtt 357301 ccgtttttcc ttgttcacca taaaggaaaa tgaagtgtgg ttttacgcaa atgttcatca 357361 cgtgatttct gatggtatct ccatgaatat tctcgggaat gcgatcatgc acatttattt 357421 agaattagcc agcggctcag agacaaaaga aggaatctcg cattcattta tcgatcatgt 357481 tttatctgaa caggaatatg ctcaatcgaa gcggtttgaa aaggacaagg cgttttggaa 357541 caaacaattt gaatcggtgc ctgaacttgt ttccttgaaa cggaatgcat ccgcaggggg 357601 aagtttagat gctgagaggt tctctaaaga tgtgcctgaa gcgcttcatc agcagattct 357661 gtcgttttgt gaggcgaata aagtcagtgt tctttcggta tttcaatcgc tgctcgccgc 357721 ctatttgtac agggtcagcg gccagaatga tgttgtgacg ggaacattta tgggcaaccg 357781 gacaaatgcg aaagagaagc agatgcttgg catgtttgtt tctacggttc cgcttcggac 357841 aaacattgac ggcgggcagg cgttttcaga atttgtcaaa gaccggatga aggatctgat 357901 gaagacactt cgccaccaaa agtatccgta taatctccta atcaacgatt tgcgtgaaac 357961 aaagagctct ctgaccaagc tgttcacggt ttctcttgaa tatcaagtga tgcagtggca 358021 gaaagaagag gatcttgcct ttttgactga gccgattttc agcggcagcg gattaaatga 358081 tgtctcaatt catgtaaagg atcgatggga tactgggaaa ctcaccatag attttgatta 358141 ccgcactgat ttattttcac gtgaagaaat caacatgatt tgtgagcgca tgattaccat 358201 gctggagaac gcgttaacgc atccagaaca tacaattgat gaattaacac tgatttctga 358261 tgcggagaaa gagaagctgc ttgcgagggc cggcggtaaa tctgtgagct accgtaagga 358321 catgacgata ccagagctgt tccaagaaaa ggctgaactg ctttctgatc atccagcggt 358381 tgtatttgaa gatcgcacat tgtcctatcg aacgttacat gagcaatctg cacgcatcgc 358441 caatgtgctg aaacagaaag gggttggccc ggacagtcct gtcgcggttt tgattgaacg 358501 ctctgaacgg atgattacag ctatcatggg aattttaaaa gccggcggag cctatgtgcc 358561 gattgatccg ggttttcctg ctgagcgcat tcaatatatt ttggaggact gcggggcgga 358621 tttcatcctg actgaatcga aggttgcggc gcctgaagcc gatgctgagc tgattgactt 358681 agatcaggcg attgaggaag gtgcagaaga aagcctgaat gcagatgtga acgctcggaa 358741 ccttgcctac attatttaca catcgggaac aaccggacgc ccgaaaggcg ttatgatcga 358801 gcatcgccag gttcatcatt tggttgaatc tctgcagcag acgatttatc aaagcggcag 358861 ccaaaccctg cggatggcat tgcttgcgcc gttccacttt gatgcgtcag tgaagcagat 358921 cttcgcgtcg cttcttttgg gccaaaccct ttatatcgta ccgaagaaaa cagtgacgaa 358981 cggggccgcc cttactgcat attatcggaa gaacagcatt gaggcgacgg acggaacacc 359041 ggctcatttg caaatgctgg cagcagcagg cgattttgaa ggcctaaaac tgaagcacat 359101 gctgatcgga ggagaaggcc tgtcatctgt tgttgcggac aagctgctga agctgtttaa 359161 agaagccggc acagcgccgc gtttgactaa tgtgtacggg ccgactgaaa cgtgcgttga 359221 cgcgtctgtt catccggtta tccctgagaa tgcagttcaa tcagcgtatg tgccgatcgg 359281 gaaagcgctg gggaataacc gcttatatat tttggatcaa aaaggccggc tgcagcctga 359341 aggcgtggcg ggtgagcttt atatcgcggg agacggtgtg ggccgaggct atttacattt 359401 gcctgaatta acggaagaga agtttttaca agatccattc gtgccgggcg atcgcatgta 359461 ccggaccggg gacgtggtgc gctggcttcc agatggaaca atcgaatatt taggcagaga 359521 ggatgaccag gtcaaagtcc gcggataccg gattgagctt ggggaaattg aagccgtgat 359581 tcagcaggcg ccagacgttg caaaagccgt tgttttggca cgccctgacg aacagggaaa 359641 tcttgaggtt tgcgcatatg ttgtgcagaa gcctggaagc gaatttgcgc cagccggttt 359701 gagggagcat gcggccagac agcttcctga ctatatggtg ccggcttact ttacagaagt 359761 gacagaaatt ccgcttacac caagcggcaa agtcgaccgc cgcaagctgt ttgcactaga 359821 ggtgaaggct gtcagcggca ctgcctatac agcgccgcga aatgagactg aaaaagcaat 359881 cgcagccatt tggcaggacg tgctgaacgt tgagaaggcg gggatctttg acaatttctt 359941 tgaaactggc ggacattcat taaaagccat gaccctttta acaaagattc ataaggaaac 360001 aggcattgag attccgcttc aatttttgtt tgagcatccg acgattacgg ctcttgcaga 360061 ggaagctgat cacagagaaa gcaaagcttt tgcggtgatt gaacctgctg aaaaacagga 360121 gcattacccg ctttcattgg cacagcagcg aacatatatc gtcagccagt tcgaggatgc 360181 gggagtcggc tataacatgc cagcagcagc aattctggaa gggcctttag atattcaaaa 360241 gctggagcgc gcatttcagg gattaatccg acgccacgag tcattgagaa catcatttgt 360301 tcttgaaaac agcacgccga gacagaaaat tcacgatagc gttgatttca acatcgaaat 360361 gattgaaaga ggcggccgct cagatgaggc aattatggct tcattcgttc ggacatttga 360421 tttggcgaaa gctccgctgt tcagaatcgg tttgctgggg cttgaagaga accgtcatat 360481 gctgctgttt gacatgcacc atttgatttc tgacggtgta tccattggca ttatgctgga 360541 ggagttagca cgcatttata aaggcgaaca gcttcctgat cttcgtctcc agtataagga 360601 ctacgctgta tggcaaagca gacaggctgc tgaagggtac aagaaggacc aggcttattg 360661 gaaggaagtc tttgcaggcg agctcccggt gcttcagctt ctgtccgatt acccaagacc 360721 acctgttcaa agctttgaag gggatcgggt gtcaatcaag ctggatgcgg gggtaaagga 360781 tcgcctcaat cgtttggctg aacaaaacgg cgccacttta tatatggtga tgctttccgc 360841 ttactatacg cttttgtcaa agtatacggg gcaggatgac atcattgtcg ggacaccgtc 360901 agcgggcaga aatcactccg atacagaggg cattatcggg atgttcgtca atacgcttgc 360961 gattcgcagt gaggtgaagc agaatgagac gtttacccaa ttgatctcgc gtgtccgcaa 361021 acgggtgctg gatgcctttt ctcatcagga ctatccgttt gagtggcttg ttgaagattt 361081 gaacatcccg cgtgatgtta gcaggcatcc gctgtttgac acgatgttca gccttcaaaa 361141 cgcgacagag ggcattccgg ctgtcggcga tctttccttg tctgttcaag agaccaattt 361201 caagattgcc aaatttgatt tgacggtgca ggcgagagaa accgatgaag gcattgagat 361261 tgatgtggat tacagcacaa agctgtttaa acaaagcacg gcagacaggc tgcttacgca 361321 ttttgcgcgt ttgcttgaag atgctgcggc tgatccagag aagccgattt ctgagtataa 361381 gcttctttct gaagaggagg ctgcttcgca aattcagcag tttaacccgg gcagaacacc 361441 ttatccgaaa gataaaacaa ttgttcagct gtttgaggag caagcggcga atacgccaga 361501 ccacactgcg cttcaatatg aaggcgaatc actcacttat cgtgaactga atgaacgggc 361561 caatcgttta gcccgcggca ttctttctct tggagctggc gaaggcagaa ctgcggctgt 361621 cttatgcgag cggtcaatgg atatgattgt gtcgatcttg gcagtattaa aatcaggttc 361681 ggcttatgtt ccgatcgatc cggaacatcc gattcagcgg atgcagcatt tcttccgtga 361741 cagcggagca aaggtgcttc tcactcagag gaaattaaag gctttggcgg aagaagcgga 361801 atttaagggc gttatcgtgc tagccgatga ggaagaaagc tatcatgccg atgcgcgaaa 361861 tctcgcactg cctcttgatt ctgcagcaat ggccaacctg acgtatactt ccggaacgac 361921 tggaacacct aaggggaata tcgtgacaca tgccaatatt ctccgcacgg tgaaggaaac 361981 gaattatctc agcattacag aacaggatac gattctcggt ctttccaatt acgtgtttga 362041 cgcgtttatg ttcgatatgt tcggctcttt gttaaacgga gccaagctgg tgctgatacc 362101 gaaggaaacc gttttggaca tggctcgcct gtcccgcgtc attgaacggg agaacatcag 362161 cattctcatg attacaaccg ctttgttcca cttgcttgtg gacttgaatc cggcatgctt 362221 gtcaacgctt cgcaagatta tgtttggcgg ggaacgggct tcggttgagc atgtcagaaa 362281 agctttgcaa acggttggaa agggcaagct ccttcatatg tatggaccgt ctgaaagcac 362341 ggttttcgcg acgtatcatc cggttgatga attggaggag cacacgctgt ctgttccgat 362401 tggaaaaccg gtcagcaata cggaagtata cattcttgac cgtacgggac acgtgcagcc 362461 tgccgggatt gccggagagc tttgcgtcag cggcgaagga ctcgtgaaag gctattacaa 362521 ccgtccagaa ctgactgagg agaaatttgt tccccatccg tttacatccg gcgaacgcat 362581 gtataaaacg ggagaccttg cgagatggct gccgaatggc gacatcgaat ttatcgggcg 362641 aatcgaccat caggtgaaga ttcgcggaca gcgcatcgag cttggagaaa tcgaacatca 362701 gctgcaaacc catgatcgtg ttcaggaaag tgttgtgctt gccgttgatc aaggagcggg 362761 agataaactg ttgtgtgctt actatgtcgg agaaggagac atctcatcac aagagatgag 362821 agagcatgct gcgaaggact tgccggcata tatggttcct gcggtgttta tccaaatgga 362881 cgagctgccg ctgacaggga acggaaaaat tgaccggaga gcgctgccga ttcctgatgc 362941 caacgtttca agaggtgttt catatgttgc gccacgcaat ggaacggaac aaaaagtcgc 363001 ggacatttgg gcacaggtac ttcaggcaga acaagtcggc gcttatgacc acttctttga 363061 cattggcgga cattcattag caggcatgaa gatgcttgcc ttggttcatc aggaactggg 363121 cgttgagctg tcactcaagg atctcttcca gtcaccgacg gttgagggct tggcacaggt 363181 gattgcctct gctgaaaaag ggacagccgc aagtatcagc ccggcagaga aacaagatac 363241 gtatcctgtt tcttcaccgc aaaaacggat gtacgtgctt cagcagcttg aggatgcgca 363301 aacgagctat aacatgccgg cggttctgcg cctgacaggt gagcttgatg ttgaaaggct 363361 taacagcgtc atgcagcagt taatgcagcg tcatgaagcc ttgagaacca cgtttgaaat 363421 aaaagatgga gaaacggtgc agcggatctg ggaagaggct gagtgcgaga tagcctattt 363481 cgaagccccg gaagaagaga cagagcggat cgtttctgag tttattaagc ctttcaaaat 363541 cgaccaactt ccactgttca gaatagggct tatcaagcat tcagacactg agcatgtgct 363601 gctgttcgat atgcatcata ttatttctga tggtgcatct gtcggtgtgc tgattgagga 363661 gctttcaaag ctgtacgacg gagaaaccct tgagccgctc cgtattcaat ataaggatta 363721 tgccgtgtgg cagcagcagt tcattcagtc tgagctttac aagaagcaag aagagcattg 363781 gctgaaggag ctggacggag agctgccggt gctgacgctt ccgactgatt acagtcggcc 363841 tgccgttcaa acatttgagg gagaccgcat tgcattttca ttagaagcag gcaaagctga 363901 tgctctgcgc aggcttgcaa aagaaacgga ttccacgctt tacatggtgc ttctggcttc 363961 atacagtgcg tttttatcaa aaattagcgg gcaagacgat atcatcgtcg gttcacctgt 364021 ggccggacga tctcaagcgg acgtcagccg cgtcatcgga atgttcgtca atacattggc 364081 gctgcgcacg tatccgaagg gtgaaaagac gtttgctgac tatcttaacg aagtgaaaga 364141 aacggcactc agcgcttttg atgcgcagga ttacccactt gaggatttga tcggaaatgt 364201 tcaggttcag cgtgacacaa gcagaaatcc gttattcgat gcagtttttt caatgcaaaa 364261 tgcgaatata aaggatttaa caatgaaagg gattcagctt gagccgcatc cgtttgaacg 364321 gaaaacagcc aagtttgacc tcacgctgac ggctgacgaa accgacggag ggcttacatt 364381 cgtactcgaa tacaatacag ctctgtttaa gcaggaaacg attgaacgat ggaagcaata 364441 ttggatggag cttttagatg cagttactgg gaacccgaac cagccgcttt ccagcctgtc 364501 actggtcacc gagacagaaa agcaagcgct tcttgaggca tggaagggca aagcgctgcc 364561 tgtgccgaca gacaaaacgg ttcatcagct attcgaagag actgcccagc gccacaaaga 364621 ccgcccggct gtcacataca acggccagtc ttggacgtac ggcgagctga atgcgaaggc 364681 aaaccgtctc gcgcggattc tgatggactg cggcatcagc ccggatgacc gcgtcggcgt 364741 tctcacgaag ccgtcgcttg aaatgtccgc cgcggtgctc ggcgtcttga aagccggagc 364801 ggcgtttgtg ccgattgatc ctgactatcc ggatcagcgg attgagtata ttttacagga 364861 cagcggcgcg aagcttctct tgaaacagga aggcatttca gtgccggaca gctatacggg 364921 agatgtcatt cttctcgacg gaagccgcac gattctaagc ctgccgcttg atgaaaacga 364981 cgaggaaaat ccagaaaccg ctgtaaccgc ggagaacttg gcgtacatga tttacacgtc 365041 tggaacgacc ggacagccga agggtgtcat ggtcgagcac catgcgcttg tgaacctgtg 365101 cttctggcac cacgacgcgt tcagcatgac agcggaggac cgcagtgcga agtacgcggg 365161 ctttgggttc gacgcttcca tttgggagat gttcccgacc tggacgatcg gtgccgaact 365221 tcacgtcatt gaggaagcga tccgcctcga tatcgtccgc ctgaacgatt attttgaaac 365281 gaacggcgta acgatcacgt tcctgccgac acagcttgcg gaacagttca tggagcttga 365341 gaacacatca cttcgcgtat tgcttactgg aggagacaag ctgaagcgcg cagtgaaaaa 365401 gccgtacaca ctcgtcaata actacgggcc gacagagaat acggtcgttg ccacaagcgc 365461 agaaatccat ccggaggaag gctcgctttc catcggaagg gccattgcca atacgagagt 365521 atacattctc ggcgagggca atcaggtgca gccggaaggc gtagccggag agctttgcgt 365581 ggcggggcgc ggactggcac gcggctatct gaatcgagaa gacgaaaccg cgaagcggtt 365641 tgtcgctgat ccgtttgtgc cgggtgagcg catgtaccgc accggcgatt tggtgaaatg 365701 gacgggcggc ggcatcgaat acatcggccg gatcgaccag caggtcaagg tccgcggcta 365761 ccggatcgag ctctcagaaa ttgaagtcca gctcgcccag ctttctgagg tgcaggatgc 365821 ggcggtgaca gctgtcaaag ataaaggcgg caacacagcg atcgcggcgt atgtcacacc 365881 ggaatcagct gacatagaag cactgaaatc agcactgaag gaaaccctgc cggattacat 365941 gatcccggcg ttctgggtga cgctgaacga gcttccggtt acggcaaacg gcaaagtgga 366001 ccgcaaagcc ttgcctgagc cggacatcga agcgggaagc ggagaataca aagcgccgac 366061 gaccgacatg gaagagctgc ttgccggcat ctggcaggac gtgcttggaa tgtctgaagt 366121 cggtgtcacc gacaatttct tctcgcttgg cggagattcc atcaaaggaa ttcaaatggc 366181 gagccgcttg aaccagcacg gctggaagct ggaaatgaaa gatctcttcc agcacccgac 366241 gatcgaagag ctcacccagt acgtagagcg tgccgaaggc aaacaggcag accaaggccc 366301 ggtggagggc gaagtcatcc tgacgccgat ccagcgctgg ttctttgaaa agaacttcac 366361 gaacaagcac cactggaacc aatctgtgat gcttcacgcc aagaagggct ttgatcctga 366421 acgggtggag aaaacattgc aggcgctgat cgagcatcat gacgcgctcc gcatggtcta 366481 tcgtgaggga caggaagacg tcattcaata caacagaggt cttgaagctg cttcagctca 366541 attggaggtc atccagattg agggccaagc tgcagattac gaagaccgaa tagagagaga 366601 agcggagcgt ttgcaaagca gcatcgactt gcaggaaggc ggcttgttaa aagcaggctt 366661 gttccaagcg gaagacggag atcacttgct tcttgccatt caccacttag tggttgacgg 366721 cgtgtcgtgg cggattttac tggaggattt cgccgcggta tatacacagc ttgagcaagg 366781 caatgaaccg gttctcccgc agaaaacaca ttcatttgca gagtatgcag agagattgca 366841 agacttcgcg aactccaaag cctttttgaa agaaaaagag tattggagac agcttgaaga 366901 acaagctgtt gcggcaaagc ttccgaaaga ccgcgaatct ggtgatcagc gaatgaaaca 366961 tacaaagaca attgaattct cgctgactgc tgaagagaca gaacagctca ccacaaaggt 367021 gcatgaggca tatcacacag aaatgaatga tattttgctg acggcattcg gattggcaat 367081 gaaggagtgg acgggtcaag atcgagtaag tgttcattta gaggggcatg gacgtgaaga 367141 aatcatagaa gacctgacca tttctcgcac agtcggctgg tttacaagta tgtacccaat 367201 ggtgctcgat atgaagcatg cggatgatct gggctaccag ctgaagcaaa tgaaagaaga 367261 tatcagacat gtgccgaata agggagtcgg atacggcatt ctgcgctatc tgacggcacc 367321 ggaacataaa gaagatgtgg cgttctcgat tcagccggat gtcagcttca actatttagg 367381 tcagtttgac gaaatgtcgg atgcaggttt gtttacgaga tcagagctgc catcaggaca 367441 gtcattaagc cctgaaacag aaaaaccgaa tgcgctggat gttgtcggat atatcgaaaa 367501 cggaaaactg acgatgtcac tggcctatca ttctcttgaa tttcatgaaa aaacagtaca 367561 aacattcagt gacagcttta aagcgcatct tctcagaatc attgaacatt gcctatctca 367621 agatggtacg gaactgaccc cgagtgatct tggtgacgac gatttgacgc tggatgagct 367681 ggataaatta atggaaattt tctaatagag gtggcatatg agcaaaaaat cgattcaaaa 367741 ggtgtacgca ctgacaccaa tgcaggaggg aatgctgtat catgcgatgc ttgatccgca 367801 ttcttcctcg tacttcacac aattagagct tgggattcac ggcgcttttg atcttgaaat 367861 ctttgagaaa agcgtcaatg aactgattcg gtcatacgat attctccgta cggtatttgt 367921 gcatcagcag ctgcaaaaac cgcgtcaggt cgtgttagcg gaacgcaaaa caaaagtgca 367981 ttatgaggat atcagtcatg cagacgaaaa ccgccagaaa gagcacattg agcgttacaa 368041 acaagacgtt cagcgccaag gctttaacct ggcaaaagac atattgttca aggtagcggt 368101 tttccgcctt gctgcagatc agctgtatct tgtctggagc aatcatcata ttatgatgga 368161 cggctggagc atgggcgtcc tcatgaaaag cctgttccaa aactatgaag cgctcagagc 368221 aggcaggaca ccggcaaacg gtcagggcaa gccttattcc gattacatca agtggcttgg 368281 aaaacaggac aatgaagaag cggagagcta ctggagcgag cgcttggcgg gttttgaaca 368341 gccaagcgtg ctcccgggcc gcctgcctgt gaaaaaagac gaatacgtca ataaagaata 368401 ttcatttaca tgggacgaaa cactggttgc ccgtattcag caaaccgcaa atctccatca 368461 agtgacaggg cctaacctat ttcaggccgt ttggggcatt gttctcagca aatacaactt 368521 tacggatgat gtgatcttcg gaacggtcgt ctcgggacga ccgtctgaaa tcaacggaat 368581 cgaaacgatg gcggggctgt ttatcaacac cattccagtg cgggtgaaag ttgaacgaga 368641 tgctgcattc gctgatattt tcacagctgt tcagcagcat gcagtagagg cagagcgtta 368701 cgattacgtg ccgctctatg agattcaaaa acgctcagct cttgatggca atctcttaaa 368761 ccatctggtc gcgtttgaaa attatccgct tgatcaagag cttgaaaacg gcagcatgga 368821 agaccgcctc gggttttcga ttaaggtaga aagcgcattt gaacaaacga gcttcgattt 368881 caacctgatt gtgtatccgg gcaaaacgtg gaccgtcaaa attaaatata acggagccgc 368941 ctttgattcc gcttttatcg aacggacagc ggagcacctt acccgcatga tggaagcagc 369001 tgtcgatcag ccggccgctt ttgtgcgtga gtacgggctt gtgggagacg aagagcagcg 369061 gcaaattgtc gaggtgttta acagcacgaa agccgaactc cctgaaggaa tggctgttca 369121 ccaagtgttt gaagagcaag cgaaacggac gccggcgagc accgccgtcg tatatgaagg 369181 aaccaagctg acgtaccgcg agctgaatgc agcggctaac cgtctggcga gaaagcttgt 369241 cgaacatggg cttcaaaaag gggaaacagc agcgattatg aacgaccgct cagtagaaac 369301 cgttgtcggc atgctggctg ttttaaaagc aggcgccgca tatgtgccgc ttgatccagc 369361 gcttcctggg gatcgtcttc gtttcatggc agaggacagc tccgttcgaa tggttttgat 369421 cggaaattct tatacagggc aggcacatca gctgcaagtg ccggttctta cactggacat 369481 aggctttgaa gagagtgaag cggctgacaa tctcaacctg ccatccgccc cgtctgattt 369541 ggcgtacatc atgtacacat ccggttcaac gggcaaaccg aaaggcgtca tgatcgaaca 369601 taaaagcatt ctgcgcctcg tcaaaaatgc cgggtacgtt cctgttactg aagaagaccg 369661 catggcgcaa acgggagctg tcagctttga tgccggaacg tttgaggtat tcggcgcact 369721 gctgaatggc gcagcacttt atccggtcaa aaaagagaca ctgcttgatg cgaaacaatt 369781 tgctgcattc ctgcgtgagc aaagcatcac aactatgtgg ctgacatcac ctttattcaa 369841 ccagcttgct gcaaaggatg cgggtatgtt cggcacactg cgccatttaa tcatcggcgg 369901 agatgccctt gtcccgcata ttgtcagcaa agtaaaacag gcatcgccgt cgctttcatt 369961 gtggaacgga tacggcccga cagaaaacac gacgttttca accagttttc tgatcgaccg 370021 cgagtatggc ggctctatcc caatcgggaa gccgatcgga aattccactg cctatattat 370081 ggatgagcag caatgcctgc agccaatcgg cgcgcctggt gagctttgcg taggcggaat 370141 cggtgtagcg cgtgggtatg tcaatctccc tgagctgacg gagaagcaat ttctggaaga 370201 cccgttcaga ccgggtgaga gaatttaccg cactggtgac ttggcaagat ggctgccgga 370261 cggcaatatc gaatttttag gcagaatcga caaccaagtg aaggtgcgcg gcttccgaat 370321 tgagcttggc gaaattgaaa caaaactgaa catggctgag catgtgacag aagccgcggt 370381 gatcatacgc aagaacaaag cagacgaaaa tgaaatttgc gcgtacttca cggcggatcg 370441 tgaagtggct gtgagtgagc tgagaaaaac actgtctcag tctttgcctg actatatggt 370501 ccctgcccac ctgattcaaa tggacagcct gccgctcacg ccaaacggga aaatcaacaa 370561 aaaggaactg cctgcaccgc aatcagaagc cgtgcagccg gaatacgcag caccaaaaac 370621 agagagtgaa aagaaattag cggagatctg ggaaggaata ctcggcgtca aagcaggcgt 370681 taccgataac ttctttatga tcggcggcca ttctttgaaa gcgatgatga tgacggcgaa 370741 aattcaagag cattttcata aggaagttcc gataaaagtg ctttttgaaa agccgactat 370801 tcaagaactg gcactgtatt tggaagagaa cgaaagcaag gaggagcaga cgtttgaacc 370861 gatcaggcaa gcatcttatc agcagcatta tcctgtatcc ccggcccagc ggagaatgta 370921 tatcctcaat cagcttggac aagcaaacac aagctacaac gtccccgctg tacttctgct 370981 ggagggagaa gtagataaag accggcttga aaacgcgatt cagcaattaa tcaaccggca 371041 cgaaatcctc cgtacatcgt ttgacatgat cgacggagag gttgtgcaaa ccgttcataa 371101 aaacatatcg ttccagctgg aggctgccaa gggacgggaa gaagacgcgg aagagataat 371161 caaagcattt gttcagccgt ttgaattaaa ccgcgcgccg ctcgtccgtt cgaagcttgt 371221 ccagctggaa gaaaaacgcc acctgctgct cattgatatg catcatatta ttactgacgg 371281 aagttcaaca ggcattctaa tcggtgatct tgccaaaata tatcaaggcg cagatctgga 371341 actgccacaa attcactata aagattacgc agtttggcac aaagaacaaa ctaattatca 371401 aaaagatgag gaatactggc tcgatgtctt taaaggcgaa ctgccaatac tggatcttcc 371461 cgcggatttc gagcggccag ctgaacggag ctttgcggga gagcgcgtga tgtttgggct 371521 tgataagcaa atcacggctc aaatcaaatc gctcatggca gaaacagata cgacaatgta 371581 catgtttttg ctggcggcgt tcaatgtact cctttccaag tacgcgtcac aggatgatat 371641 cattgtcggc tcgccgacag ctggcagaac acatcctgat ctgcaaggtg tgccgggtat 371701 gtttgtcaac acggtggcac tcagaacggc accagcggga gataaaacct tcgcgcaatt 371761 ccttgaagag gtcaaaacag ccagccttca agcattcgag caccagagct atccgcttga 371821 ggagctgatt gaaaagcttc cgcttacaag ggatacaagc agaagtccgc tgttcagcgt 371881 gatgttcaac atgcagaata tggagattcc ttcattaaga ttaggagatt tgaagatttc 371941 ctcgtattcc atgcttcatc atgttgcgaa atttgatctt tccttggaag cggtcgagcg 372001 tgaagaggat atcggcctaa gctttgacta tgcgactgcc ttgtttaagg acgagacgat 372061 ccgccgctgg agccgccact ttgtcaatat catcaaagcg gccgcggcta atccgaacgt 372121 tcggctgtct gatgtagatc tgctttcatc tgcagaaacg gctgctttgc tagaagaaag 372181 acatatgact caaattaccg aagcaacctt tgcagcactt tttgaaaaac aggcccagca 372241 aacacctgac cattctgcgg tgaaggctgg cggaaatctg ttgacctatc gcgagcttga 372301 tgaacaggcg aaccagctgg cgcatcatct tcgtgcccaa ggggcaggaa atgaagacat 372361 cgtcgcgatt gttatggacc ggtcagctga agtcatggta tccattctcg gtgtcatgaa 372421 ggcgggggca gctttccttc cgattgatcc tgatacacct gaagaacgaa tccgttattc 372481 attagaggac agcggagcaa aatttgcggt cgtgaatgaa agaaacatga cggctattgg 372541 gcaatatgaa gggataattg tcagccttga tgacggtaaa tggagaaatg aaagcaagga 372601 gcgcccatca tccatttccg ggtctcgcaa tcttgcatac gtcatttata cgtccggtac 372661 gaccggaaag ccaaagggcg tgcagattga gcatcgtaat ctgacaaact atgtctcttg 372721 gtttagtgaa gaggcgggcc tgacggaaaa tgataagact gtattgcttt catcttacgc 372781 atttgacctt ggctatacga gcatgttccc tgtacttctg ggcgggggcg agctccatat 372841 cgtccagaag gaaacctata cggcgccgga tgaaatagcg cactatatca aggagcatgg 372901 gatcacttat atcaagctga caccgtctct gttccataca atagtgaaca ccgccagttt 372961 tgcaaaagat gcgaactttg aatccttgcg cttgatcgtc ttgggaggag aaaaaatcat 373021 cccgactgat gttatcgcct tccgtaagat gtatggacat accgaattta tcaatcacta 373081 cggcccgaca gaagcaacga tcggcgccat cgccgggcgg gttgatctgt atgagccgga 373141 tgcatttgcg aaacgcccga caatcggacg cccgattgcg aatgccggtg cgcttgtctt 373201 aaatgaagca ttgaagcttg tgccgcctgg agcgagcgga cagctctata tcacgggaca 373261 ggggctcgcg agagggtatc tcaacaggcc tcagctgaca gccgagagat ttgtagaaaa 373321 tccatattcg ccgggaagcc tcatgtacaa aaccggagat gtcgtacgaa gactttctga 373381 cggtacgctt gcatttatcg gccgggctga tgatcaggtg aaaatccgag gctaccgcat 373441 tgagccgaaa gaaattgaaa cggtcatgct cagcctcagc ggaattcaag aagcggttgt 373501 actagcggtt tccgagggcg gtcttcaaga gctttgcgcg tattatacgt cggatcaaga 373561 tattgaaaaa gcagagctcc ggtaccagct ttccctaaca ctgccgtctc atatgattcc 373621 tgctttcttt gtgcaggttg acgcgattcc gctgacggca aacggaaaaa ccgacagaaa 373681 cgctctgccg aagcctaacg cggcacaatc cggaggcaag gccttggccg caccggagac 373741 agcgcttgaa gaaagtttat gccgcatttg gcagaaaacg cttggcatag aagccatcgg 373801 cattgatgac aattttttcg atttaggcgg ccattcatta aaagggatga tgctgattgc 373861 caacattcag gcggaattgg agaaaagcgt accgcttaaa gcactgttcg agcagccgac 373921 agttcgccag ctggcggctt atatggaggc gtctgctgtt tcaggcggcc atcaagtact 373981 caaaccggct gacaagcagg atatgtatcc attgtcatcc gcacagaaac gaatgtacgt 374041 gctcaatcag cttgaccgcc agacgataag ctacaacatg ccatctgttc ttctaatgga 374101 aggagagctt gatatttcgc gcctgcgcga ctcactcaat cagcttgtga accgtcacga 374161 atcattgcgg acgtcattta tggaagctaa tggtgagcct gttcagcgca tcattgagaa 374221 ggcggaggtt gatcttcatg tgtttgaagc caaagaagac gaagcggacc aaaagattaa 374281 ggaatttatc cggccattcg acttaaacga cgcaccgctc attcgcgcag ctttgcttcg 374341 aatagaagcg aaaaaacatt tgctgctttt agatatgcat catatcatcg cagacggcgt 374401 ctcaagaggc atctttgtaa aagaattggc gctgctttac aaaggagagc agcttccgga 374461 gccgacgctt cattataaag atttcgccgt ttggcaaaat gaagctgagc aaaaagaacg 374521 gatgaaggag catgaggcgt actggatgtc agttctttca ggcgagctgc cagagcttga 374581 tctcccgctc gattatgccc gtccgcctgt gcaaagcttt aaaggagata cgatccgttt 374641 ccgtacggga agtgagacgg caaaggcggt agaaaaactg cttgccgaaa ccggaacgac 374701 cttgcacatg gtgctccatg ctgttttcca cgtcttttta agcaaaattt ccggacagcg 374761 ggatatcgtc atcggctccg ttactgccgg ccggacgaat gctgatgttc aggacatgcc 374821 gggaatgttc gtcaatacac ttgccctgag aatggaagcg aaagaacagc aaacatttgc 374881 ggagcttttg gagctagcaa agcagacgaa cctgtcagcc cttgagcatc aggagtatcc 374941 gtttgaagat ctggttaatc agcttgatct ccctcgggat atgagccgaa acccattgtt 375001 taatgtgatg gtgacgacag aaaaccctga taaagaacag cttacattgc aaaatctgag 375061 catttcacct tatgaggctc atcagggaac ttctaagttt gatctgacac tgggcggatt 375121 tactgatgaa aatggcattg gcttgcagct cgaatatgcg acagatctgt tcgcaaaaga 375181 aacagctgaa aaatggagcg aatacgttct gcggctacta aaggctgttg cggataaccc 375241 gaaccagccg ctttccagtc tgttactggt caccgagaca gaaaagcaag cgcttcttga 375301 ggcatggaag ggcaaagcgc tgcctgtgcc gacagacaaa acggttcatc agctattcga 375361 agagactgtc cagcgccaca aagaccgccc ggctgtcaca tacaacggcc aatcttggac 375421 gtacggcgag ctgaacgcga aggcaaaccg cctcgcccgg attctgatgg actgcggcat 375481 cagcccggat gaccgcgtcg gcgttctcac gaagccgtcg cttgaaatgt ccgccgcggt 375541 gctcggcgtc ttgaaagccg gagcggcgtt tgtgccgatt gatcctgact acccggatca 375601 gcggattgag tatattttac aggacagcgg cgcgaagctt ctcttgaaac aggaaggcat 375661 ttcagtgccg gacagctata cgggagatgt cattcttctc gacggaagcc gcacgattct 375721 aagcctgccg cttgatgaaa acgacgaggg aaatccagaa accgctgtaa ccgcggagaa 375781 cttggcgtac atgatttaca cgtctggaac gaccggacag ccgaagggtg tcatggtcga 375841 gcaccatgcg cttgtgaacc tgtgcttctg gcaccacgac gcgttcagca tgacagcgga 375901 ggaccgcagt gcgaagtacg cgggcttcgg gttcgacgct tccatttggg agatgttccc 375961 gacctggacg atcggcgctg aacttcacgt cattgatgaa gcgatccgcc tcgatatcgt 376021 ccgcctgaac gattattttg aaacgaacgg cgtaacgatc acgttcctgc cgacacagct 376081 tgcggaacag ttcatggagc ttgagaacac atcacttcgc gtcctcttga ccggaggaga 376141 caagctgaag cgggcagtga aaaagccgta cacactcgtc aacaactacg ggccgacaga 376201 aaatacggtc gttgccacaa gcgcagaaat ccatccggag gaaggctcgc tttccatcgg 376261 acgggccatt gccaatacga gagtatacat tctcggcgag ggcaatcagg tgcagccgga 376321 aggcgtagcc ggagagcttt gcgtggcggg gcgcggactg gcacgaggct atctgaatcg 376381 agaagacgaa accgcgaagc ggtttgtcgc tgatccgttt gtgccgggtg aacgcatgta 376441 ccgcaccggc gacttggtga agtgggtgaa cggcggcatc gaatacatcg gccggatcga 376501 ccagcaggtc aaggtccgcg gctaccggat cgagctctca gaaattgaag tccagctcgc 376561 ccagctttct gaggtgcagg atgcggcggt gacagctgtc aaagataaag gcggcaatac 376621 agcgatcgcg gcgtatgtca caccggaaac agctgacata gaagcactaa aatcaacact 376681 aaaggaaacc ctgccggatt acatgatccc ggcgttctgg gtgacgctga acgagcttcc 376741 ggttacggca aacggcaaag tcgaccgcaa agccttgcct gagccggaca tcgaagcggg 376801 aagcggagaa tacaaagcgc cgacgaccga catggaagag ctgcttgccg gcatctggca 376861 ggacgtgctt ggaatgtctg aagtcggtgt caccgacaat ttcttctcgc ttggcggaga 376921 ttccatcaaa ggaattcaaa tggcgagccg cttgaatcag cacggctgga agctggaaat 376981 gaaagatctc ttccagcatc cgacgatcga agagctcacc cagtacgtag agcgtgccga 377041 aggcaaacag gcagaccaag gcccggtgga gggcgaagtc atcctgacgc cgatccagcg 377101 ctggttcttt gaaaagaact tcacgaacaa gcaccactgg aaccaatcgg tgatgcttca 377161 cgccaaaaag ggctttgatc ctgaacgggt ggagaaaaca ttgcaggcgc tgatcgagca 377221 tcatgacgcg ctccgcatgg tctaccgcga ggaaaacggg gacatcgttc aggtgtataa 377281 accgatcggt gagagcaagg tcagcttcga aatcgtggat ctgtacggct ccgatgaaga 377341 gatgctgaga agccagatta agcttctcgc gaacaagctg caaagcagtc tcgatctgcg 377401 aaacgggccg cttttaaagg cggagcaata tcgcacagaa gctggggatc acctgctcat 377461 tgctgtacac catctcgtgg tcgacggtgt gtcatggcgg attttgcttg aagactttgc 377521 ttcaggctac atgcaggctg agaaagaaga gagccttgtc ttcccgcaaa aaacaaactc 377581 cttcaaggat tgggcggaag aactggcggc attcagccaa tcagcgcatc ttttacagca 377641 ggctgaatac tggtcgcaaa ttgccgctga acaggtttct cctttaccta aggattgtga 377701 aacagagcag cggatcgtca aggatacatc atctgtccta tgtgaattaa cggcagaaga 377761 cactaagcat cttttaacag atgttcatca gccatatgga actgaaatca acgatattct 377821 tctcagcgcg ctcggtttga caatgaaaga atggacaaag ggggccaaaa ttggcattaa 377881 ccttgaggga cacggccggg aggacattat cccgaatgtg aatatctcca gaacggtcgg 377941 ctggtttacg gcacaatacc ctgttgtgct cgacatatct gacgcagatg cctcagctgt 378001 gatcaaaaca gtcaaagaaa acctgcgccg cattccggac aaaggtgttg gctacggcat 378061 tcttcgttat ttcacagaaa cagcggaaac aaagggcttc acaccggaga tcagcttcaa 378121 ctatttgggc caattcgaca gtgaagtcaa aaccgatttc tttgaaccgt ccgctttcga 378181 tatggggcgc caagtaagcg gagaatcaga ggcgctgtac gcattaagct tcagcggcat 378241 gatcagaaac ggccggtttg tgctttcctg ctcctacaat gagaaggagt ttgaaagagc 378301 tacagtcgag gagcaaatgg aacggtttaa agaaaacctc ctgatgctaa tccgccattg 378361 cacggaaaaa gaagacaagg aattcacacc aagcgacttc agcgccgaag accttgaaat 378421 ggacgagatg ggagatatct ttgacatgct tgaggagaat ttaaaataaa acgcaaggga 378481 attacagaag gcgggagcga aacatatgag tcaatttagc aaggatcagg ttcaagatat 378541 gtattaccta tcgccgatgc aggaagggat gctttttcat gccatcctga atcccggcca 378601 aagcttttac cttgaacaaa tcacgatgaa agtaaaaggc agcttgaata tcaaatgtct 378661 tgaagaaagc atgaatgtga tcatggaccg gtacgatgta tttcgtaccg tgttcattca 378721 cgaaaaagta aaaaggcctg tccaagtcgt attgaaaaaa cggcagttcc atatagaaga 378781 aatcgatctg acacacttaa cgggcagcga gcaaacagcc aaaatcaatg agtacaaaga 378841 acaggataag atcaggggtt ttgatttgac gcgggatatt ccgatgcggg cagccatttt 378901 caagaaagct gaagaaagct ttgaatgggt gtggagctac caccacatta ttttggacgg 378961 atggtgcttc ggcatcgtcg tacaggatct atttaaggta tacaatgctc tgcgcgaaca 379021 aaagccgtac agcctgccgc ccgtcaaacc gtataaagac tacatcaagt ggcttgaaaa 379081 gcaggataaa caagcatcac tgcgttactg gcgcgaatat ttagagggct ttgaaggaca 379141 aacgacgttt gcggagcaaa gaaagaaaca aaaggacggc tatgagccga aagagctgct 379201 cttttcactg tcggaggcgg aaacaaaggc ctttaccgag cttgcaaaat cgcagcatac 379261 cactttgagt acggcgctgc aggcagtctg gagcgtattg atcagccgct atcagcagtc 379321 tggcgatttg gccttcggta cagttgtttc agggcgtccc gcggaaatca aaggcgttga 379381 acatatggtc gggctgttta tcaacgttgt cccgagacgt gtgaagctgt ctgagggtat 379441 cacatttaac ggcttgctca agcggctgca ggagcaatcg ctgcagtccg agccgcatca 379501 atatgtgccg ctttatgaca tccaaagcca ggccgatcag ccgaaactga ttgaccacat 379561 cattgttttt gagaactatc cgcttcagga tgcgaaaaat gaagaaagca gtgaaaacgg 379621 ctttgatatg gtggatgttc atgtttttga gaagtcgaat tatgatctca acctgatggc 379681 ttccccggga gatgagatgc tgattaagct tgcctataat gagaatgtgt ttgatgaggc 379741 gtttatcctg cgcttgaaat ctcagcttct tacagcaatt cagcagctca tccagaatcc 379801 tgatcagcct gtcagcacga tcaacctcgt tgacgacagg gagagagaat ttttgctaac 379861 cggcttaaac ccgccggctc aagctcatga aacaaagcct ctgacgtatt ggttcaagga 379921 agcagtgaac gccaatccgg atgcaccggc gcttacgtat tccggccaga ccctgtctta 379981 tcgcgaatta gatgaggaag cgaaccgcat tgcacgccgg ctgcaaaaac acggtgcggg 380041 caaaggctct gttgtagcgc tgtacacgaa gcgctcactt gaactggtga tcggcattct 380101 cggtgtatta aaggcgggag cagcctatct gccggttgat ccgaagctgc cagaggaccg 380161 aatctcgtat atgctggctg acagtgcggc agcctgtctt ctgacgcatc aggagatgaa 380221 agaacaagcg gctgagctgc cgtatacagg cacaacgctc ttcattgatg atcaaacacg 380281 gtttgaagaa caggcaagcg atcctgcaac cgcgattgat cctaatgatc cggcatatat 380341 catgtacacg tccggcacaa ccggaaagcc aaagggcaat atcaccactc atgccaatat 380401 tcaaggattg gtcaagcatg tagactacat ggcattttct gatcaggata cgttcttgtc 380461 tgtttcgaat tacgcctttg atgcatttac ctttgatttc tatgcttcta tgctgaatgc 380521 ggcacggctc attatcgcag atgaacatac gctgcttgat acagaacggc tcacagatct 380581 gatcctgcaa gagaatgtca atgtcatgtt tgcgacaacc gcactattta atcttctcac 380641 agatgcggga gaggattgga tgaaggggct tcgctgtata ttattcggcg gagagcgcgc 380701 gtcagtgcct catgtcagaa aagcgctgcg gatcatgggg ccgggcaagc tgattaactg 380761 ctacgggccg actgagggaa cagtgtttgc gacagctcac gtcgtgcatg atctgccgga 380821 ttccatctcc tcattgccga tcggaaagcc gatcagcaat gccagtgttt atattctgaa 380881 tgagcaaagc cagctccagc cattcggggc ggtcggtgaa ctgtgcatca gcggaatggg 380941 cgtgtcaaaa gggtatgtaa atcgtgctga cctcacgaag gaaaagttta tcgagaaccc 381001 gttcaagccg ggagaaacgc tttaccgtac aggggattta gcgcgctggc tgccggatgg 381061 aacgattgaa tacgccggcc gtattgacga ccaggtcaaa atacgcggac accggattga 381121 gcttgaagaa atcgaaaagc agctgcagga atacccaggt gtgaaagatg cggtcgttgt 381181 ggcggaccgc catgagtctg gcgatgcatc aatcaatgcc taccttgtga accgaacgca 381241 gctttcagct gaagacgtga aggcgcacct gaaaaaacag cttcctgctt acatggtgcc 381301 gcaaaccttt accttcttgg atgagcttcc tttaacgacg aacgggaaag tcaataaacg 381361 gctgctccca aaacctgatc aggatcagct ggcggaagaa tggattggac cgcggaacga 381421 gatggaagaa acaatcgcac aaatatggtc tgaggttctc ggcagaaagc aaattggcat 381481 tcatgacgat ttctttgcgc tcggagggca ttccttgaag gccatgaccg ccgcgtcccg 381541 catcaagaaa gagctcggga ttgatcttcc agtgaagctt ttgtttgaag cgccgacgat 381601 cgccggcatt tcagcgtatt tgaaaaacgg gggctctgat ggcttgcagg atgtaacgat 381661 aatgaatcag gatcaggagc agatcatttt cgcatttccg ccggttctgg gctatggcct 381721 tatgtaccaa aatctgtcca gccgcttgcc gtcatacaag ctatgcgcct ttgattttat 381781 tgaggaggaa gaccggcttg accgctatgc ggatttgatc cagaagctgc agccggaagg 381841 gcctttaaca ttgtttggat attcagcggg atgcagcctg gcgtttgaag ctgcgaaaaa 381901 gcttgaggaa caaggccgta ttgttcagcg gatcatcatg gtggattcct ataaaaaaca 381961 aggtgtcagt gatctggacg gacgcacggt tgaaagtgat gtcgaagcgt tgatgaatgt 382021 caatcgggac aatgaagcgc tcaacagcga agccgtcaaa cacggcctca agcaaaaaac 382081 acatgccttt tactcatact acgtcaacct gatcagcaca ggccaggtga aagcagatat 382141 tgatctgttg acttccggcg ctgattttga catgccggaa tggcttgcat catgggaaga 382201 agctacaaca ggtgtttacc gtgtgaaaag aggcttcgga acacacgcag aaatgctgca 382261 gggcgaaacg ctagatagga atgcggagat tttgctcgaa tttcttaata cacaaaccgt 382321 aacggtttca taaatgaagt gatgaaagga ggagacagcc aatgagccaa ctcttcaaat 382381 catttgatgc gtcggaaaaa acacagctca tctgttttcc gtttgccggc ggctattcgg 382441 cgtcgtttcg ccctctccat gcttttttgc agggggagtg cgagatgctc gctgccgagc 382501 cgccgggaca cggcacgaat caaacgtcag ccattgagga tctcgaagag ctgacggatt 382561 tgtacaagca agaactgaac cttcgccctg atcggccgtt tgtgctgttc ggacacagta 382621 tgggcggaat gatcaccttc aggctggcgc aaaagcttga gcgtgaaggc atctttccgc 382681 aggcggttat catttctgca atccagccgc ctcatattca gcggaagaaa gtgtcccacc 382741 tgcctgatga tcagtttctc gatcatatta tccaattagg cggaatgccc gcagagcttg 382801 ttgaaaataa ggaggtcatg tcctttttcc tgccttcttt ccgatcagat taccgggctc 382861 ttgaacaatt tgagctttac gatctggccc agatccagtc gcctgttcat gtctttaacg 382921 ggcttgatga taaaaaatgc atacgagatg cggaagggtg gaagaagtgg gcaaaagaca 382981 tcacattcca tcaatttgac ggcgggcaca tgttcctgct gtcacaaacg gaagaagtcg 383041 cagaacggat ttttgcgatc ttgaatcagc atccgatcat tcaaccgtga tcaaaagcgg 383101 acagcttcgg ctgttccgct ttttttgtgt tgaatgccaa tttctgcatg gtataatagt 383161 cgaaatactc aaataaaggc aggtcgaaac atgcgcacgt ctcccaggat gaaatggttt 383221 gtattgctgt ttacgtttgt tttcgccatc ggaatgaact cattcagaaa ttcctttcaa 383281 ttttttatgc tgccaatggc agacgccttc catgccgaca ggtcgctgat ttcggtttct 383341 gtcagcattt ttatgatcac aaccggcatc gtccagtttt ttgtcggttt ttttatcgac 383401 cgtttcagtg tcagaaaaat tatggcgctg ggagctgttt gcatcagcgc aagctttttg 383461 gtgcttcctt attcaccgaa tgttcatgtg ttttccgcca tttacggtgt gcttggcgga 383521 atcgggtatt cctgcgcggt cggcgtgacg acccagtatt tcatcagctg ttggtttgac 383581 acacacaaag gtctggcgct tgctattttg accaatgcca actctgcggg cctgctgctt 383641 ctctcgccca tttgggctgc ggctccgtat catgccggct ggcagagcac ctataccatt 383701 ttgggaatcg tcatggcggc tgttctgctg ccgctcctcg tctttgggat gaagcacccg 383761 ccacatgcgc aagcggaaac tgtgaaaaaa tcttatgatt ggcgagggtt ttggaacgtg 383821 atgaagcaat cccgcctcat tcatatcctg tacttcggcg tgtttacttg cggatttaca 383881 atgggaatta ttgatgctca cctcgtcccg atactgaagg atgcgcatgt ctctcatgtc 383941 aacggaatga tggccgcgtt cggggcattt atcatcattg gcggattatt ggcgggctgg 384001 ctgtcagatc tcctcggcag cagaagcgtc atgctatcca tcttattttt cattcggctg 384061 ctcagcctca tttgcctgct cattcccatt ctcggaattc atcacagcga cctttggtac 384121 ttcgggttta tcctgttatt cgggctcagt tacacaggcg tgatcccgct gaccgcggcg 384181 tcaatttcgg aaagctatca aacaggattg atcggatcgc tgttaggcat caatttcttt 384241 atccatcagg ttgccggagc tctcagcgtg tatgcgggcg gtttgttttt tgacatgact 384301 catggttatt tactgattgt cgctgtgtgc atcgtgtttg tgggtttatc ggctgtaata 384361 gagctggtgc cgtttttaga taaacagaag gcaaaagaaa cccaccattc aatataaaag 384421 gatcagcact gtcaatgctg atccttttta aatttgagtt tttttgtttc ggtattttta 384481 aggataatct ccttgaatct gttcatctcc tcttcggagt gaaaaaaatg tttggggatc 384541 gcaatatatt ggccacttga tgtattgacc ctgaagatat ttttatattc gaaaacagct 384601 gtaatttcat cccaattgaa aatgaggtca tattttttag aacatatacg aattccttct 384661 tggttcagag tatatgttct tttggatttc atccgttcgt tcttcttgta tgctctggaa 384721 aacttcacat atagaagaag gaggagcagc agtgtaaaca gaacggacat cacgataatc 384781 aacatactgt tcataaacaa gttaagcgcg tcacttccat aaacgatacg gggccatccg 384841 ttaatgaagt taactgcagc aaatatggcg caaaacaata gaaagtaaaa gcatgatatt 384901 tttgcgattt gataaaaaaa gatttctctt acatccttaa aagtgatttc tcctggaaga 384961 ttgatacttt cactagcata ttgaatcata cggtaaacct acacctctaa ccatgttttt 385021 ccttttagtc tagcataatt tctcattttt ttgcaggcat accagggcgc tttgtttttt 385081 tctccagatt gatattgctc cccaccacgc caatcataat acaaacagcc ccggcaagat 385141 gataccaggc caggctttcg ttgagaatca caaatcctgc aatcatcgtc acaatggtag 385201 atacatgatt aaaagcgctc attttaaacg cctcaattcg cgacagcgta tagttagaca 385261 gaaatgaagt gacaagtgaa gacagcacgc ccaaatacac aatggcgaga acgaagccgg 385321 gctcccggaa cggcagaaaa taagtgccga ctgttcccgc cgctccgtga cgcacaaggg 385381 cgatggcgtt gaagacgaca aagccgatgg ctgacatgat gtaggtgagc tcggtcagct 385441 tgaaccgctg cgtcattttt ctggcagcag tattgtacat cgctgaagac aaagcggaca 385501 ataggatcag caaagaccct tttaagctgg ctgattccac gtcaacgcct ttcatcacaa 385561 aaataaacat gacgccggca acggataaaa ccgtgaaccc cttttgcgtc cacgttgggc 385621 gttcctttaa aacataagcg gcaaagacca tcgtgaaaat cggaatggct gcctgaataa 385681 ttcccgcttc agaggaggac gagtacacaa ggccgaatgc ctgaaagctg aaaaataacg 385741 cgggatacag cagggcgagc ggcaaaatgt caatgacgtc ctttacgcgg attgatagct 385801 ttacccagcc gaataagatc ggtacagtgg ccgcagcaaa cgcaatggtg aaccgatgcg 385861 ccaaaatatc aaacggctct gctgtttgca gtgcgatttt tacgaataga aaggataaac 385921 cgataatgaa cgaatataaa atagccgcta tataagcggg ggtttgctga tgtttaacca 385981 taatgggaag ggctccttta cctgaattgc agcgccggtc gctcccttta ttgtatggcc 386041 gcggtcagaa cggtacaatg agaaaaacaa tgaactgtac cggtacaaaa cagggggaga 386101 aggcatggag aaatatatga gtctattaac gaggatagag gagatgatgc aaagcacctc 386161 atatcaagaa ggagacaggc ttccatctat ccgtcagctg tccgcccgct accaagtcag 386221 caaaagcaca gtgatccgcg cgctgcagga gctggaaaag cgccacctta tctattctgt 386281 tccgaaaagc ggctattata ttgtgaaaaa gtcagggaaa tcaaaaagcg ggcagcctgg 386341 ccccatcgac tttgccacat ctgcgccgga tcccgatgtg tttccgtatc ttgattttca 386401 gcactgcatc aacaaagcga ttgatacata caaaaacgat ttgtttattt atgggacgcc 386461 aaaggggctt ccatcactca tccgcgtact ccgaaagctc ttggccactc aacaggtatt 386521 tgcggatgaa cggcatattt tcattacatc aggtgtccag caggcgttat ccttgctttg 386581 tgccatgccg ttcccaaatg ggaaagagaa gatcgccatt gaacagccgg gctaccattt 386641 gatggtcgaa cagcttgaga cacttgggat tcccgccatc ggggtgaaac gaacggaaga 386701 agggcttgat atagccaagg ttgagcggtt atttcaaaca gaatcgatta aattttttta 386761 tacgatgccg cgcttccata acccgcttgg gtgctcattg tcagagcgtg ataaacagga 386821 gcttgtgaga ctggcagaag cgtatgatgt ctatctcgtt gaggatgatt acctcggtga 386881 tctggaggaa aataaaaagg cagatccgct gtacgcatat gatctgtcct cacatgtcat 386941 ctatttgaaa agcttctcga aaatgatgtt ccccggcctc cgcgtggggg cggctgtttt 387001 gcccgaagcg ctgactgaca cgttctatgc gtacaaaaag ctgaacgaca tcgactgttc 387061 gatgatttct caagcggcat tggagattta cctgaaaagc ggtatgtacg gcaggcataa 387121 ggagaaaatc agagattctt ataaagagcg gtcgctgagg ctacatcaag ccattcgaac 387181 tcacaggcag ctgggaagcg gacgctttac gttctccagc gggcaggcac cctgtatgca 387241 cacccatctg gtgcttcctc aggatctgcc cgcctcaaga gtgattcata gactggaaaa 387301 acaaggggtt ctccttgagg cgatagaccg tcattattta tcagattatc cgaaagaaaa 387361 tctattaaaa atcaatattt ccaatgtgaa aacggaagat attgagcgcg gtgtcaagct 387421 gttgatgagc catttataaa agctcttcgt acgagaccat tgtgatatcc tcggggaaat 387481 cagggtgtac ggcgcataca gccattttgt agccgggatc gacctcatac gttttgatat 387541 agcatgggga atggctgtcc ggaagctcaa tggatacttg tccgtcctgg tgcaggcgca 387601 ctgaaaagga atcaagcgga agcgataagc ctttgccttc cttgtttgat aaagctttct 387661 ttcattgacc atagatgata aaaatagtct gtctgctcgt ccttgtcttt tgctaaaagg 387721 tcgctgtact ctgtttttga aaagaagcgc ttggcgatct caaggctgat cggtttcgtt 387781 ttttcgatat ctatgccgat cggctgtgaa tcaaacgcgc aaatgaccca gcgtccggag 387841 tgagaaatgt tgaaatgagc gtcgggaaga tcagggatgc acggcttccc gtattcctgc 387901 gtgctaaagc ggatatcgga tttgtccaac tgatactgcc tgcttatgac tgagcgaacg 387961 agcacatctc ccagcagggt gcggtgagca tcttctttat gataaaatct ccggcatttc 388021 tcccgttttt caggtgatat gaaagacatg aaccgttcat tttcttcctg tgaaagcggg 388081 cggtccatat aaattccgta aatcttcatt ctagatcctc cgtctgcaaa agattgtcaa 388141 aaccatccta tcatacttcc acaagactca tatagaggag aaaataaaaa aacaaagcca 388201 aggcggcttt gttttagtgt acaggcggag atgctttcac tgcggctgtc cgccttgcca 388261 cagcataatt cagcaactgg attgactggg gcaatgaaaa acgcaaaata agtccggtga 388321 ggatggcggt caaaatggtg ccaaaaccga tcggtccgcc catgccccat gccgcaaaca 388381 aaatggttaa ttccatgccg ttccgcaccc attgcacatt ccagccggtt ttttctgtaa 388441 tcagcatcat cagtgaatca cgcggccccg cgccaaggcc tgctgataca taaacaccga 388501 cgccgtaacc aatcagcacc acgcctagag agaagacgat gatcgagcct gtgtaggtcg 388561 agagggcagg cagaatgaaa ttgaaaaaat ctataaatac accaatgagc accatattca 388621 ggagggcacc aattttcggc caagctctcg taaacaatga cgtgaatccg acgatgagcg 388681 ctccaataat gatggaccac tggccgacgg taagcccgaa gtgctgaaac aggctgtaat 388741 gaaatgcatc ccacggacta atgccgagtg cttttccttc tatcgtcagg gatacaccaa 388801 aagccaaaat gatcaaaccg gcaaaataaa atgtccagcg cagaacaagt tcttgcttca 388861 cgtgaggtcc cttctttcgt aaaaatcagt cgattgtcat tgtagcacat ctgacagaag 388921 ggcggaatag gcgaaagggg ctcaacaaaa aaacagggcc gccggaggcg ccctgtttca 388981 gcgtgttggc aaacccttgc attcgttgtc aggcctgtgc ttcggtgctc acgaatttaa 389041 cattagctgt gctccaatgc tcgcccttcc tagacttcaa aggttttcaa tcacgctgaa 389101 aatcacaaaa tcctaaaacg aatatcgttt taggattttg tcaataatct gaaacagggc 389161 gctgacgctc tgtttttctt attacagcgg gttcaaaatc cggtttaaga accgctgtgt 389221 ccgttcttct tttggtgcgg agaaaatttg ctccggcggt ccctgctcca cgataacgcc 389281 gccgtcgatg aagatgactt catccgcaac ctcctgcgcg aacttgattt cgtgggtcac 389341 gacgaccatg gtccagcctt cattggccaa gtccttgata accttcagca cctctccgac 389401 aagctcggga tcaagcgctg aggtcggttc gtcaaacagc atgagctcag gctgtatcgc 389461 cagtgcgcgg gcgatgccga cgcgctgctg ctggccgccg gaaagctgga acggatataa 389521 atccattttg tccttcaatc cgactttatc aagaagctga atcgcttctt ttctgacttc 389581 ctctttgttc cgtttttgca cctgaacagg gccctccatc acgttttcga gggctgtgcg 389641 gtgcgggaac aggtgatacg cctgaaacac cattccggat tttcggcgaa gctttaggat 389701 atccgcctgt ttcacctttt tggagaaatc gatggagaaa tcatcaaatg caagctctcc 389761 gcgattcggg atctccagag cgttcaggca gcggagcagc gtcgttttcc ctgaacctga 389821 aggcccaagt atggcgatga cttttccttt ttcaatcttc atatctatct tttttaaaat 389881 ttcattttca ccgaatgatt tgtttaatcc tttaacggta agcatactcg gaacctcctt 389941 atttggccac gtagcggtca agacgccgtt cgatgacatg ctggacgagt gagagcagga 390001 agcagataat ccaataaata aaggctgctt caatatagat cactaaaatt tgatcaagat 390061 tccgcgcgcc gatttcctgg gcttttctga acagctcagc gaccagaatt tgagaggcga 390121 gggatgtatc tttaatcagg ctgataaagg tattggataa tggcgggatc gacacacgaa 390181 acgcctgcgg caaaatgacg cggaacagcg ttttttgatg tgtcatgcca attgtgtagc 390241 cggcttccca ttgccctttc ggcacggata aaatagatgc ccgaatgatt tcagatgcat 390301 aggcgccgac gtttaatgaa aaggcgataa ctgcgcttgg aaatggatct aatgtgacgt 390361 taaaggccgg gaacagatag aaaatgatga acaattgaac gagaagagga gtgccgcgta 390421 ttgcggatac gtatacgctg aacacccatc tcaaaggtct cactttcgac attctggcaa 390481 gcgccgtaat cagcgccagg atcattccga atataaagga aagaatcgta aggggaatcg 390541 tatagtagat tccccctgaa agtatcggcc agaatgactg ctgcaccaga tcccacggga 390601 tcgccgtgcc aagcgtcaat gccggcagat tatttagaaa catcttcgcc gaaccatttt 390661 ttagaaattt tagaaagagt cccgtcctct ttcatttctt ttaatgcttt gttgacttga 390721 tcaacaacct cgccgcttcc tttacggaac gtgaaatatg ttgactgagg ctcacctgtt 390781 tcaaacgcga ttttcacgtt tttattgcca gatgttttta agtagttcaa tacggcaagc 390841 ttatcgttgt atgtcatatc gacgcggcct tgctggatca tttgaagggc ctgcgccatg 390901 ccttcaacgc cttctacttt agcgccggca tttgtagcta atttgttgta gttgcttgtc 390961 agtgattgag ctgacgtttt tccttttaca tctgcttcag acttaatatc gttgttgtct 391021 tttttcgtta cgacaacggc tcttgatgtt gtgtatttat ctgagaaatc atatttgtct 391081 tcacgatctg tttttccgac ttggttggca acaacgtcaa accgtttgga attcaggccg 391141 gcaaacatac tgtcccattg tgtttcctta aagtcgactt taagcccgag gcgttttgcg 391201 acttctgtga taacttcgac atcatagcca gtcagtttat cagtgtcttt gtcgtggtaa 391261 gtgaacggct catatgttcc ttccgttccg actgtgagca cacctttttt cttaattgaa 391321 gcccaaagat cgccatcttt ggcattatct tttgactgat tgtcatttcc tgctccgcaa 391381 gctgcaagag ctgcaatact tacgaccatg aataaagcca ataatgcttt tttcatctta 391441 ttccccactt ttctggttga ttttattgaa ataaaaaatt agcttacaaa tctaaaggat 391501 aacttttttt tagtatgagt caagtatttg gttttcataa gacaaaatct tttaaaataa 391561 atccaaaaat tgctgtgccg gtttaggcaa ataactgtcc gttctccaca tgacagccgg 391621 tgtcataatg aagggattat tttcgatatg gacggtgtga acgtgatttc tcatatgaac 391681 gggaatcatt gtgacaggca aaatagacgc gccgaatccg gatgacacga ggctgagcaa 391741 agttgcagag tcgtggcatt cacaaacaat gcgcggctcc aggttcaaac gatgaaattc 391801 attcatgacc tgattataga cgccttttcc gttgacaggc cgcagcagga tcagcggaaa 391861 tgaaggaatg tccaccatct taatggtgtc tccgcacgga tatccggctt catctgaaag 391921 cacgagcaca catggaatgt catcaagctg cttgaattgt actgtgtcac ttttgatcag 391981 tgttgtcgtg accgccgcat cgatttgccg gctttccagc agttccaaca gtgtcgcggg 392041 ttcattttcc caaatattaa aggtgagatg ggggtatctc tctttgatct gtgttacttt 392101 ttcaagcatc agagccgcgc aataaatcgt tgatcccacg gcaagtgtac cggctacttc 392161 ctccttcagc tcctgtacct caatgactgc atcttcaaac ctatgcagaa tctcttttgc 392221 tctttttaga aaaacagctc cttcatatgt aagagtcatt tgttttttct tgttacggtc 392281 aaacagaaca acaccaagtt cgtcctccag ctgtttgagc tgcctgctta aaggcggctg 392341 cgccatgtga agctttttgg ctgcggacgt aattttctgt tcttgggcaa tggtaatgaa 392401 gtatcgaagc tggcgaatat ccaaaagaaa gcgcctcctt atcatacctt ttaggtatta 392461 attatagatt taatagatat ttttcatatg gatatatcag gagtatgatt gaaatgaaag 392521 cagaattcaa gcgtaaagga gggggcaaag tgaaactcgt tgtcggaatg acaggggcaa 392581 caggggccat tttcggggtc aggctgctgc agtggctgaa ggccgccgga gtggaaaccc 392641 atctcgttgt gtctccttgg gcaaacgtca cgatcaaaca cgaaacaggc tatacgttac 392701 aagaagtaga acaactggcc acatacactt actcacataa ggatcaggcg gcagccattt 392761 caagcgggtc gtttgatacc gatggaatga ttgttgcgcc gtgcagcatg aaatctctcg 392821 caagcattcg cacaggaatg gcggataatc tgctgacacg tgcggcggat gtcatgctca 392881 aggagagaaa aaaactcgtc ctcttaacga gagagacgcc tttgaaccaa attcatctcg 392941 aaaatatgct agcgcttacg aaaatgggca ccatcattct tcctccgatg ccggcatttt 393001 ataatcggcc gagaagctta gaggaaatgg ttgaccatat tgtttttaga acgttggacc 393061 aattcggcat tcggcttcct gaagcgaagc gctggaatgg gattgaaaaa caaaaaggag 393121 gagcttgatc atggcttatc aagatttcag agaatttctc gctgcccttg aaaaagaagg 393181 acagctgctt acagtgaatg aagaggtaaa gccggaaccg gatttagggg cctccgcacg 393241 ggcagccagc aatcttggcg ataaaagccc tgcgctctta tttaacaaca tttacggcta 393301 tcataacgcg cgaattgcga tgaatgtcat cggctcttgg ccaaaccatg ccatgatgct 393361 gggcatgccg aaagacacac cggtaaaaga acagtttttt gaattcgcaa agcgttatga 393421 ccagtttccg atgccggtca aacgtgagga aacagcgcca tttcatgaaa atgaaatcac 393481 agaagatatc aatttgttcg atatactgcc tcttttcaga attaaccagg gtgatggagg 393541 ctactattta gacaaagcat gtgtcatttc ccgtgatctt gaggaccctg acaacttcgg 393601 caaacaaaat gtcggcattt acagaatgca agtcaaagga aaagaccgcc ttggcattca 393661 gcctgtcccg cagcacgata ttgcaatcca tctgcgccaa gctgaagaac gcggcatcaa 393721 ccttccggtc actattgcgc tcggctgtga gccggtcatt acaacggcgg catcgactcc 393781 gcttctctat gatcaatcag aatacgaaat ggcaggtgcg attcaaggcg aaccatatcg 393841 catcgtcaaa tcaaagctgt ctgatcttga tgttccgtgg ggcgctgaag tggtgcttga 393901 aggtgagatt attgccggag agcgcgaata tgaagggccg ttcggtgaat tcacaggcca 393961 ttattccggc ggacgcagca tgccgattat caaaattaaa cgcgtctatc acagaaacaa 394021 tccgatcttt gaacatttat acttaggcat gccttggaca gaatgcgatt acatgatcgg 394081 cattaacaca tgcgtgccgc tttatcagca gttaaaagaa gcgtatccga acgaaattgt 394141 ggcagtgaac gccatgtaca cacacggttt aatcgcgatt gtttccacaa aaacccgcta 394201 tggcggattt gcgaaagcgg tcggcatgcg cgcactcaca acgccgcacg gactcggcta 394261 ctgcaaaatg gtcatagtcg ttgatgagga tgtcgatcca ttcaaccttc cgcaggtcat 394321 gtgggcgctt tcgaccaaaa tgcatccgaa acatgatgcg gtcatcattc cggacttatc 394381 tgtcctgccg cttgatccgg gatccaatcc atcaggaatc actcacaaaa tgattctcga 394441 cgccactaca ccggttgcgc cggaaacaag aggccattat tcacagccgc ttgattctcc 394501 gctaacaacg aaagaatggg aacaaaaact aatggactta atgaataaat aaggaaagga 394561 tgttcgaaat gcatacatgt cctcgatgcg actcaaaaaa gggagaagtc atgagcaaat 394621 cgcctgtaga aggcgcatgg gaagtttatc agtgccaaac atgctttttt acatggagat 394681 cctgtgaacc ggaaagcatt acaaatcccg aaaaatacaa tccagcgttt aaaattgatc 394741 caaaggaaac agaaacagca attgaagttc cggcggtgcc ggaacgaaag gcttgatccg 394801 cgtgaactgt atgtcagacc gtctctttga gctgcttgac gggagctgcc tgaatgagaa 394861 gcagcatgag gccttcgttc tgcaaacagt atcagaggat ggctggccgc atgccgctat 394921 gatcagtgca ggtgaaatca tcgcgctgag ccgaactgat atccgaatcg ctctgtggaa 394981 aaacacaatg acttcggcca acatccttcg cacaggaaaa gcacagttca cggcgtggtg 395041 gaagggagcg gcctattatg taaagcttga atgcgcgcct ttaccgcctt tgaaagatgc 395101 cgaatatgaa agagaccgtt tttcctgccg catcgtttca gtgaaagagg acgttgcgaa 395161 atacgctgat ttgacttcag gtgtccgtat acagcttcac agccctgaag aggtgctgag 395221 cagatggaaa aagaccctgg aagatttaaa acggtaatat cgatagcctg acgccatgcg 395281 tcaggctttt tttatataat gaaaacaaaa gggggcgtga gaaatggaac gtgcggggat 395341 ctgtcactcg gacggctttg atttagctta tcgaattgag ggcgagggcg cacccatcct 395401 tgtgatcggg agtgcggttt actatccgcg ccttttttcc tcagatatca aacagaaata 395461 tcaatgggtc tttgtcgacc ataggggatt tgctaagcct aagcgggagc ttcgtgcgga 395521 ggattcgagg cttgatgctg tcttggctga tatcgaaagg atgagaacat ttcttcagct 395581 tgaggatgtt actatcctgg gacattccgg gcacgctttt atggctttag agtatgccag 395641 gacatatccc aaacaagttc ggaaggtggc gctctttaat actgcgcctg ataacagtga 395701 agaaagacag cgaaaaagcg aatcattttt catggaaaca gccagtcttg agagaaagaa 395761 acgctttgaa aaagacatcg agaatttgcc gcaggacatc gacaaagatc ctgaaaggcg 395821 ctttgtgcac atgtgtattc gcgctgaagc gaaaagcttt tatcaagagc ggccgcatgc 395881 tgctgcctta tgggacggtg tattcacgaa tatgccgatc attgatgaat tatggggcaa 395941 tacatttgcc cggattgatc ttcttcagcg gttagctgat gttcgtatgc cggtgtatat 396001 cggattaggg agatatgatt atttggttgc gcccgtttcg ctatgggatg ctgttgacgg 396061 tttatatccc catgttgata aggttatttt tgaaaagagc ggccatcagc cgatgctgga 396121 agaaccggaa gcctttgatc aaagcttcag gaaatggctt gatcaataaa aaacagcccg 396181 cagatcaaca tccgcgggct gtttctgatt ataagacccc tttcatcgcg cgtttgatca 396241 ccggcgagag cagcaggaga atgccgccaa gaacgataga aatcaaaccg atggtgccga 396301 agtacattgt ttcaggaatt ttatcaaaca atccggctac ttgggcattg atcgcttggg 396361 ctgctgcgtt cgtcagaaac cacatactca ttgtctgtgc agagaaggca gctggtgcca 396421 gtttcgttgt cacggataaa ccgactggag acaggcacag ctctccaagc acgacaagca 396481 ggaagctgag aacgagccaa agcgggctta cgagtgcttc ttttccttgc atagcaggga 396541 ataccataat gataaatgac aatccggcta aaataattcc gattgagaat ttaactggtg 396601 tagacggctg acgtttgcca agcttcatcc agagccatgc gaatattggc gcaaaaatga 396661 caacaaacaa tggatttaat gattggaacc atgatgactg aagttcgaat ccgcccaatg 396721 aaagtcttat gcgttcatca gcgtataccg caagaatggt cgctccctgt tcctgaatgg 396781 cccagaacat gacagcaccg ataaacaaag gaacgtaagc ggcaagacgg gatttttctg 396841 ttttgtccgc ttttttgctt gtaaacatga tgatgaaata aatcacagga atcaaaatac 396901 cgagaatact tacaaggtca atgaaacgtt tgatcgtcag cacgcctgtt tgtacagaga 396961 taatcactgc gatcgccaca atgataacac cgattccggt gccaattgca gattttttag 397021 acagcggatt cggcacattg gaacctgcaa gcccgaggtt tttctttctt gtcaaagcaa 397081 atacgataag tccgagaagc attccgaccg cggcagctcc gaatccgaga tgatagttgt 397141 acttctgtcc gagtgttccg acaattaacg gcgcgagtaa accaccgagg ttaatcccca 397201 tgtagaaaat actgaaacct gagtcgcggc gcgggtcttc tttcgtgtaa agatccccaa 397261 ctacgcttga aacgtttggt tttaataagc ctgttccgac aatgataagc accatactga 397321 tatagaatgc tatcgaactg cccggatagg cgagtgcaat gtggccgaac ataatgaata 397381 tgccgccgta aaacacggtg tttgcggtac cgaatacccg gtcagcgagc catccgccaa 397441 taatggtgga catgtatacg agtgatccgt aaatcgacat aatggcaacc gcagtgccct 397501 tgtcaaagcc gagccctccg tttaccgtct ctgtatacaa atagtaaagt aagattgctc 397561 tcattccata gtaagagaaa cgctcccaaa attcggtgaa aaatagtgta aatagtcctc 397621 gcgggtgacc aaagaaccct ttttgcggga cgcttttaat gatactttcg ttatcaatcg 397681 aagccatgtc agccaaaccc tttctaaaaa aagtgtatta taaaaatcat attcttatat 397741 aatacttgtg tcaatataat ttatactcat ttcaaatagt tccatattgg aaaaattata 397801 aatacctaaa aatagtgatt tcctcctaat ttttaaactt tttatcgtga gattttctta 397861 cacaactatt cctttatatt tttttaataa aattttagag aaatgtacaa gcagatcggg 397921 aggaccgctg gtgaatcaat cccctgtaac ggggattttt ttatgtccgt aaaccgcttt 397981 gaaaagccgc tgcacaccct cctgaatatc ttcttccttc agccgtgcaa agccgataat 398041 gagagcaggc ctgcccgttt gccgcttgtt ttccttcaag ttaaatcggc tcattccgaa 398101 tatttcaagc tgcagcccgg cagcatgtga caggatgtct tgttcggtgc gcctggtatc 398161 aaattcggta acaaaatgca gccccgcatt tgcccctttt acggtaacct ctccgctgaa 398221 ctctgcttct aaagcggtga tcaggcgttc tctcttttct ttataatgct gcttcatttt 398281 ttttatatgc ttctgatatt caccagactc gataaattcc tgcagggtga gctgtgtgag 398341 tgatgagcaa gtctgcagat catagccccg ctgtttgtat gccctcaaca gctcaggcgg 398401 caacaccata tagctgatcc gtaagccggg gagaagggac tttgaaaagg ttcccatata 398461 gatgacattt tgaaaacggt cgaggctttg cagcgccgga atactgtcta catcatatgt 398521 gaattcacta tcataatcgt cctcaatgat atatcggcgc ggctcctcgg ctgcccagtt 398581 cagcagctga attcttctgg atacaggcat aatcgttccg gacggaaact gatgcgacgg 398641 ggtggtcacc agcacatctg gctgctgtct ggtgatttca gcaatcgaca tgcctttttc 398701 atccagcatg atcgtcttta cttgttttcc ggcattcttc aaaagctgat acatgcgcct 398761 gtagccaggc tcctccatcg catacacggc ttccttgggt aaaagctcag tcaacagctg 398821 catgagcacc tgtgtgcctg cccctatgat catttgttcc ggcctgcatt ttacacccct 398881 cgtcagggaa atgagcctcg taatggccgc tctcacttca tatatccctt gcggatgtga 398941 catatcgccg agcgtgcggt atgagcggga ggccgctttt tgctcgcagc ggaaccagct 399001 tttgatcgga aaatggtctg tatcggaact catgtgtgaa aacgatatcc aatcgctctg 399061 gtcgatgtga atctctttta ggtcatccgg cagtgcaaat ggagggtgct cctcggcgga 399121 aaacatgtct agttcctcca cgaagaaacc ctttcgttca atggcgtaca aatacccctc 399181 agccagcagc tgctgatagg ctgaattcac tgaatttacg ctgaccttga gattttcagc 399241 cagctcccgc ttggagggaa ccttcgagtg cggcagcaga ttgcggctga ggatttcttt 399301 tttcagcttt tgataaattt gctgatagat ataatcggct tgttctgaac gatcgagtgt 399361 aatcgtgata tccattttgt agtttctcct tctgatacca tcaaaaagtt ataattggta 399421 cttttcatca taccaaagag aagtcagaat gataagaaaa taccgacagg gggatattca 399481 catgagtcaa acaacagcaa gcatcacaac tgcacaatgg cagcaaaaac gggatcaatt 399541 tgtgtcaaaa ggtgtgagca acggcaaccg cagtctggcg gtcaaaggag aaggggccga 399601 gctgtacgat ctggatggcc ggagatttat tgattttgca ggcgccatcg gcacgttaaa 399661 tgtcggacac tcgcatccga aggtggttga ggctgtgaag cggcaggcgg aggagctgat 399721 tcatcctggt tttaatgtca tgatgtaccc gacttatatc gaattagcag aaaaactgtg 399781 cggcatcgcg ccgggcagcc atgagaaaaa agcgattttt cttaactcag gggcagaagc 399841 ggtcgaaaac gctgtgaaaa tcgccagaaa gtatacaaag cgccaaggcg ttgtctcgtt 399901 tacacgcggg tttcacgggc gcacgaatat gacgatgagc atgacaagca aggtaaaacc 399961 ttataaattc ggtttcgggc cttttgcgcc agaggtttat caagcgccgt tcccttatta 400021 ttatcagaag ccggccggca tgagtgatga aagctatgac gatatggtca ttcaagcatt 400081 caatgatttc tttatcgctt cagtggcgcc tgaaacggtg gcgtgtgtcg tgatggagcc 400141 agtgcaggga gaaggcggat ttattattcc ttcgaaacgg ttcgtacagc acgtcgcttc 400201 attctgcaaa gaacacggca ttgtttttgt tgctgatgaa atccaaaccg gctttgccag 400261 aactggcact tatttcgcaa ttgagcactt tgatgtagtg cccgatctga tcacggtttc 400321 taaatcgctt gcggcaggcc tgccattaag cggtgtgatc gggcgtgcgg aaatgcttga 400381 tgcggcagcg ccaggggagc tgggcggcac gtatgccggc agcccgctcg gctgcgcggc 400441 ggctttggca gtcttggata ttatcgaaga agaaggactg aatgagcgat ctgaagaaat 400501 tggcaaaatc attgaagaca aggcgtatga gtggaaacaa gaattcccgt tcatcggtga 400561 catccgcaga ctcggggcga tggccgcaat cgaaatcgtc aaggatcctg acacgcgtga 400621 gcctgataag acaaaagcag cagcgatcgc ggcctatgcg aatcaaaacg gattactttt 400681 gctgacagcg ggaattaacg gtaatatcat ccgctttttg acaccgctcg tcatctcaga 400741 cagcctatta aatgaagggc tcagcatctt ggaggcgggc ctgcgagctt aatcattgga 400801 aagaaaatgg ccgggtctgc tatcatttta agtaatcatg aaaagaaagg aatgttcaat 400861 atgccagatc aattaacggt ctacaacccg gctacgggcg aggagatcaa aacgattcct 400921 cagcaatcag ccacagaggt agaagaagcc attgaacgtt cacatcaagc gtttaaaacg 400981 tggtctaaaa catcagcgaa cgaaagaacg tctcttttga aaaaatggta tgagctgatt 401041 gttgaacata aagaagagct tgcagattta attacaaagg aaaacggaaa accataccag 401101 gaagcagtcg gcgaggtact ttacggcgca ggctatatcg aatggttcgc agaggaagcg 401161 aagcgtgtgt acggaagaac ggtcccggcc ccgacaactg gtaaacgaat tgttgtcaca 401221 cgccagccgg tcggccccgt tgctgctatc acgccctgga atttcccgaa tgcgatgatt 401281 acacgcaaag cggcgcctgc tcttgccgcc ggctgtacat ttatcatcaa gccggcgccg 401341 gacacaccgc tgtctgctta tgaactagcg cgcctcgcat atgaagcggg cattccgaag 401401 gatgttcttc aggttgtgat cggcgatgga gaagaaatcg gaaatgtgtt cacaagcagt 401461 ccgaaaatcc gcaaaatcac gttcacaggc tcaacacctg tagggaaaat ccttatgaaa 401521 aacagcgctg acaccgtaaa gcacgtctca atggagctcg gcggacacgc cccgctgatc 401581 gtagatgaag atgcggacat tgaccttgcc gttgaacagg cgatggcgtc caaataccga 401641 aacgccggcc aaacctgcgt atgtgccaac cgcctgatcg ttcatgaatc cattaaagat 401701 gaatttgctg cgaaactgag cgagcaagtg tctaagctga aagtcggaaa tggacttgag 401761 gaaggcgtca atgtcggccc gattatcaac aaacgaggct tcgaaaaaat cgtcagccaa 401821 atagatgatg cggttgaaaa aggcgcgaaa gtgattgctg ggggcacata tgaccgaaac 401881 gatgacaaag ggtgctactt tgtgaatccg acagtgctca ccgatgtcga tacgtccatg 401941 aacatcatgc atgaggaaac attcggcccg gtcgccccga tcgtcacgtt ttctgatatt 402001 gatgaagcga ttcagcttgc caacgataca ccgtatggct tggctgctta cttcttcaca 402061 gaaaactacc gccgcggcat ctatatttcc gagaatctag agtatggcat tatcggctgg 402121 aatgacggcg gaccgtcagc ggttcaagcg ccattcggcg gaatgaaaga aagcggcatc 402181 ggccgtgaag gcggttcaga aggtatcgag ccgtaccttg aaacaaaata tttgtccatc 402241 ggtttataaa agaatgcacg ctcctgagag ctgccggatt ttccggcagc tctttttgtg 402301 ttccggcgaa taatcacaac aattccagcc aaaataacag caaatacatt ttgaaagaag 402361 gttccccaac aatggattta ttattggctc ttctcccggc tttgttttgg gggagcattg 402421 ttctcttcaa tgtgaaatta ggcggcgggc cgtacagcca gacactggga acgacgatcg 402481 gggcactcat tgtttctatc gttatttact tttttgttca gcccgttctg tcccttcgca 402541 tttttattgt tggaatcgta tccggcttat tttggtcact tggacaggcc aaccagttga 402601 aaagcattca attgatgggc gtgtcgaaaa caatgccgat ttccacagga atgcagctcg 402661 tttccacctc gctgttcggt gtgatcgtgt tccgcgaatg gtcaacaccg attgcgatta 402721 cgcttggcgt tctcgctttg atctttatca ttgtgggaat cattctcacg tccttggaag 402781 ataagaatga taaaaaagag ggcgagccaa gcaatttgaa aaagggcatt ttgattctcc 402841 ttgtttcgac tcttggttat ttggtttatg tagtcgtggc tagattattc aatgtgtccg 402901 gctggtccgc gctgctgcca caggcaattg gcatggtggt cggggggtta gttttaacct 402961 atagacacaa accctttaac aagtatgcga tcagaaatat tctcccaggg ttaatctggg 403021 caggcggaaa tatgtttttg tttatttctc agccgcgagt cggcgttgca acgagctttt 403081 ccctttcaca aatgggaatt gtcatttcta cgctcggcgg tattttcatc ctgcgtgaaa 403141 agaaaacgaa acgccagcta atagcaattg cgatcgggat tatcctgatt attgccgccg 403201 ccgtattctt aggaatcgcc aaaacaaatt cataacaaat ggaggaggat gtatatgtat 403261 ccggatttaa aaggaaaagt cgtcgctatt acaggagctg cttcagggct cggaaaggcg 403321 atggccattc gcttcggcaa ggagcaggca aaagtggtta tcaactatta tagtaataaa 403381 caagatccga acgaggtaaa agaagaggtc atcaaggcgg gcggtgaagc tgttgtcgtc 403441 caaggagatg tcacgaaaga ggaagatgta aaaaatatcg tgcaaacggc aattaaggag 403501 ttcggcacac tcgatattat gattaataat gccggtcttg aaaatcctgt gccatctcac 403561 gaaatgccgc tcaaggattg ggataaagtc atcggcacga acttaacggg tgccttttta 403621 ggaagccgtg aagcgattaa atatttcgta gaaaacgata tcaagggaaa tgtcattaac 403681 atgtccagtg tgcacgaagt gattccttgg ccgttatttg tccactatgc ggcaagtaaa 403741 ggcgggataa agctgatgac agaaacatta gcgttggaat acgcgccgaa gggcattcgc 403801 gtcaataata ttgggccagg tgcgatcaac acgccaatca atgctgaaaa attcgctgac 403861 cctaaacaga aagctgatgt agaaagcatg attccaatgg gatatatcgg cgaaccggag 403921 gagatcgccg cagtagcagc ctggcttgct tcgaaggaag ccagctacgt cacaggcatc 403981 acgttattcg cggacggcgg tatgacacaa tatccttcat tccaggcagg ccgcggttaa 404041 acataaaaag cgacccagac atgacatctg gatcgctttc tttattaggc acgctttttc 404101 tttacaagtg ctgctacaga taaaataatg gcagccgcag acagcaccat cgctgtaatg 404161 tctagagctg aagaacctga gttttcggaa tcgtcttctg ttttcgtggc gccgtgctca 404221 tctgtcactt gctttgcaga cgtgatgttt gtaatggaat gaggtgtatc ggcatcctcg 404281 tcacctgtcc actcaacaat gctgccgtct ttgtaatatt ggtatgcgtc ccaagcagct 404341 tcctccgctt tgtcagggtt tttggcaaca aaggtaaact gctggaactg gccttcctga 404401 atgcctccgt cagtcgcctc ccatgtcacg gatactgatt tgtcatcatg tttttgagtg 404461 gaaaccttcc agcccggaat tggctcatat tgctggaatt caacatcctt cggcattttg 404521 aggacaacct tcgttgtcgg cagatttttc tcagaaggaa ccttcattgt atacgtttcc 404581 caagagcctg cagcagactc agccggtttt acagaaacat gcgcgctggc aggggccgta 404641 aagaataaga gggagccgac aatagccgga catagtgtca atgcgatttt tttcaacaac 404701 gtaaacactc cttaattggt ctttgtaaac atgatattga tttcgttaaa gtcgccggtc 404761 aggccgtgga ctttgatctt ccagtttcct ttttcattaa tcgacaggtt ttgatcttgg 404821 aagacgcctt ttgttttttc ttttaatgta aaggtgcttt tgttttcgct gcctgacagg 404881 cctgttttat aaacggttaa cgtgatttgc tggatgtttt tcacgggatc accgttatgg 404941 tcggtgaccc gcagctcaaa aacatttttt ccaggctggt ttgggctgat gctgagagaa 405001 acgctttgtc cgttctctat cgctttggtt tggtagaacg gttccggcgc tggctcaggc 405061 gggcttggca ggcttgtaaa cacggccgct gtgatcaata cagcgatgcc gattgcccac 405121 tccgctttca acgttcggct gattcctgtg cggcgctgct ttctggtaag cagaaaatga 405181 attgcgccta agaccagcat gaaaacaaac agcccgcttt tcactaaaag agcttgtccg 405241 tacgctgtat ggaacagtga atccattgaa cgaatgatga aaaatccatt gagcaagcct 405301 gaaaacaaaa tgacgccgac tgcagtgagc gcccatgggg agaaccgtct gaccgtctcc 405361 cacgcgagcg ttttgtcagg ctgcctccat tcttttgaga gcagcaaaac gagtgccgct 405421 attccgccga cccagatgga agcggaagtt aaatgaagga aatccatcaa aatgccgacc 405481 gttttttctt caacgacagc agcatgcccg gtaaacgcct tggcaagcag gagaccgaaa 405541 aagaaaatga gcggcgctgt ccaatagcca aaggatgaaa agcggttttt ccgtatcgca 405601 gggatgacag acagtgcgag cagcacgaac agcgcagcct gtatgatcca aatggagccg 405661 cctgctgtct caaacagtgt ttctctgatg tagcccggct ggaatgcgct gccccagccg 405721 ccgcctgcgt tcgcttttgt ctgaatcgga agctgaagca aaagcgccag ccccaatgct 405781 gcgatcgagc cggtcaggat acgtctcgtc cgtttgacga gctgttctga tttcccttta 405841 taccagaaaa gatggaagaa aaccgttccg ataaacagag ataaggctgt atacagaatc 405901 gcgcgatctg ctgctgttcc cggattcagc gctgaatcgg ctgctttttg gctgctgaat 405961 ccgccatccg ctttcccgat actgaacgga atgacgccgg aaacaggatg tccatccgcg 406021 gatacggcat tccattccgc tctgtacaca tctttaggca gattcttctt cagcttcact 406081 gtcatgatgt gatgattatc ttttttgatt tcagtcttgt ccgtatccac acggtcgccg 406141 tttgaattat agactttaat gtaatgaaac ccttcttcaa ccggttcatt aaattcgatt 406201 tccacctgcg caggggcgct ttttaattcg ctgttttccc caggtgaaga tttgacaata 406261 taggcgtgag caaagcttgt tttcggcagg aaaacaagaa aaagcagaag gatgatccac 406321 catctgtttc gcttcatcac tcagacacca ccttccgctg tatgtgttgt gttatttctt 406381 ggtgcaggtg cagcgtttct ttcggtcttg aagcatgtct tccagcgctt ggtcgaaagt 406441 gcagacggct ccgccgaatc ctttttgaaa tcgttcggca tggtcaagtg tcgcaaacgg 406501 aatggcctgc ggctggcagc agtgcaggtt taattcagca tttacgacga aataagccga 406561 accggcactg acggttgtct gtaacagaaa atctctgcaa atcaagtgtg aaacctcttc 406621 cgttttatcc gcgtaacgca aaaacgcgca atgtgcgcag catagctgtt caatgtcttg 406681 gtttaccgta atcagctgaa ccgaatgagc ttgattgacg ggcttcaagc aatagctgca 406741 catatgatct gtttgaggtg ttcggacggg gagcgtgatg ccgccggccg ttttaatgac 406801 ctgatttgac tgaaccagct gattgacatc tctatatacc gtcatttccg aaacgccgaa 406861 ccttgcgctg atgtcagaaa ttctaagcga gccttcttct ttcagccact tcagtatgtg 406921 ttgctgtcta ttaatcggaa gcattcatac accctcttca ttaagatcta tttaagcgta 406981 gaggatttta gagacggaga caagtaagtg gatgataaaa aatgtgaaaa tgtgttgaac 407041 agcaacaaaa cgaaacagaa gggactctgg tataatagac agatggaata gaaagtgagg 407101 aataccctat gaaagaaaca ccatgcccga actgcggcaa acctttgaca ggcgatatgg 407161 tcagatcatc aaatgtgcct tgtcaatttc gctgcggcca ctgccgggaa cggctttatg 407221 aatataaagt ttcagctccg attatgctgg tatcattagc ggccatcgtg ctgcttattt 407281 atcttttgat gctcctccgc aatgcggcag gctcagtgct gccagctgta cagcacgtgc 407341 cgatggctgt atttgcgctt gtgtgcgcgt atcccgtttt tattgtgagt gagcggatga 407401 ttgcaaagta cgtgattcaa aatggcaaca tcatttatag aggaaagaga aaaggctcct 407461 gaaaccagga gcctttttat ttttaaaaaa ttgtcacagt catgtgccaa agtcctcttt 407521 actttcaatt gtatagggac tgtaagcgtt ttaacataga gtcaaaggga agcatcattc 407581 tctgaacata tttttgtatc ttacagcgac aaacaaaaca gggagggttt atatatgcag 407641 cagcaagaac agcagcaagg cggcatgaaa gtgaaagtgc aacgctttgg gagttatttg 407701 agcggaatga tcatgccgaa tatcggcgcg tttatcgcgt ggggtatcat taccgcgctg 407761 tttattccgg caggatggtt tccgaatgaa cagctgaaca cgctggtcag cccgatgatt 407821 acgtatttat tgccgctttt gatagcgtat acaggcggaa aaatgatcta cgaccaccgc 407881 ggcggagttg tcggagcgac agcggcaatt ggggtgattg taggatcgga tattccaatg 407941 tttttaggcg caatgattat gggtccgctt ggcggatacc tcattaaaca gactgataaa 408001 ttattcaagg ataaagtcaa gcaaggcttt gaaatgctga tcaacaactt tacggcaggg 408061 attgtcggcg cggctttaac gattctcgcg ttttacgcca tcggcccggt tgtcttgacg 408121 ctaaataaat tgctggcggc tggtgtggaa gtcattgtac acgctaattt actgccggta 408181 gccagtgttt ttgtagaacc ggcgaaagtg ttgttcctta acaacgccat aaaccatgga 408241 atcttaagcc cgatcggaat cgagcaagca tctcaaacag gaaaatcaat tctgttttta 408301 gtagaagcaa accctggacc ggggctcggc attttgctgg cctacatgtt ctttggcaaa 408361 ggatcttcaa aatcaacggc tcccggtgcg gcgatcatcc atttcttcgg agggattcac 408421 gagatttact tcccgtacat tctgatgaaa ccggccctga ttctcgcagc cattgccggc 408481 ggagcaagcg gactcttaac atttacgatc tttaatgccg gacttgtcgc ggcagcgtca 408541 ccgggaagca ttatcgcatt gatggcaatg acgccaagag gaggctattt cggcgtattg 408601 gcgggtgtat tggtcgctgc agctgtatcg ttcatcgttt cagcagtgat cctgaaatcc 408661 tctaaagcta gtgaagaaga cctggctgcc gcaacagaaa aaatgcagtc catgaagggg 408721 aagaaaagcc aagcagcagc tgctttagag gcggaacaag ccaaagcaga agaagcgtct 408781 gagctgtctc ctgaaagcgt gaacaaaatt atctttgcgt gtgatgcggg aatgggatca 408841 agtgccatgg gggcatccat cttaagaaac aaagtgaaaa aagcggagct tgacatcagt 408901 gtgaccaaca cggccattaa caatctgcca agcgatgcgg atattgtcat cacccacaaa 408961 gatttaacag accgcgcgaa agcaaagctg ccgaacgcga cgcacatatc agtggataac 409021 ttcttaaaca gcccgaaata cgacgagctg attgaaaagc tgaaaaagta atcttataga 409081 aagagagtga ttgtcatgca agtactcgca aaggaaaaca ttaaactcaa tcaaacggta 409141 tcatcaaaag aagaggctat caaattggca ggccagacgc tgattgacaa cggctacgtg 409201 acagaggatt acattagcaa aatgtttgaa cgtgaagaaa cgtcttctac gtttatgggg 409261 aatttcattg ccattccaca cggcacagaa gaagcgaaaa gcgaggtgct tcactcagga 409321 atttcaatca tacagattcc agagggcgtt gagtacggag aaggcaacac ggcaaaagtg 409381 gtattcggca ttgcgggtaa aaataatgag catttagaca ttttgtctaa catcgccatt 409441 atctgttcag aagaagaaaa cattgaacgc ctgatctccg ctaaaagcga agaagatttg 409501 atcgccattt tcaacgaggt gaactgacat gatcgcctta catttcggtg cgggaaatat 409561 cgggagagga tttatcggcg cgctgcttca ccactccggc tatgatgtgg tgtttgcgga 409621 tgtgaacgaa acgatggtca gcctcctcaa tgaaaaaaaa gaatacacag tggaactggc 409681 ggaagaggga cgttcatcgg agatcattgg cccggtgagc gctattaaca gcggcagtca 409741 gaccgaggag ctgtaccggc tgatgaatga ggcggcgctc atcacaacag ctgtcggccc 409801 gaatgtgctg aagctgattg ccccgtctat cgcagaaggt ttaagacgaa gaaatactgc 409861 aaacacactg aatatcattg cctgcgaaaa tatgattggc ggaagcagct tcttaaagaa 409921 agaaatatac agccatttaa cggaagcaga gcagaaatcc gtcagtgaaa cggtaggttt 409981 tccgaattct gccgttgacc ggatcgtccc gattcagcat catgaagacc cgctgaaagt 410041 atcggttgaa ccatttttcg aatgggtcat tgatgaatca ggctttaaag ggaaaacacc 410101 agtcataaac ggcgcactgt ttgttgatga tttaacgccg tacatcgaac ggaagctgtt 410161 tacggtcaat accggacacg cggtcacagc gtatgtcggc tatcagcgcg gactcaaaac 410221 ggtcaaagaa gcaattgatc atccggaaat ccgccgtgtt gttcattcgg cgctgcttga 410281 aactggtgac tatctcgtca aatcgtatgg ctttaagcaa actgaacacg aacaatatat 410341 caaaaaaatc atcggtcgct ttgaaaatcc tttcatttcg gacgatgtga cccgcgtagc 410401 gaggtcacct ctcagaaaac tgggagaaaa tgatagactt gtaggcccgg caaagaaaat 410461 aaaagaaccg aatgcactgg ctgaaggaat tgccgcagca ctgcgcttcg atttcaccgg 410521 tgaccctgaa gcggttgaac tgcaagcgct gatcgaagaa aaaggataca gcggcgtact 410581 tcaagaggtg tgcggcattc agtcccatga accgttgcac gccatcattt taaagaaact 410641 taatcaataa ccgaccaccc gtgacacaat gtcacgggct ttttttacta tctcgcaatc 410701 tagtataata gaaagcgctt acgataacag gggaaggaga atgacgatga aacaatttga 410761 gattgcggca ataccgggag acggagtagg aaaagaggtt gtagcggctg ctgagaaagt 410821 gcttcataca gcggctgagg tacacggagg tttgtcattc tcattcacag cttttccatg 410881 gagctgtgat tattacttgg agcacggcaa aatgatgccc gaagatggaa tacatacgct 410941 tactcaattt gaagcagttt ttttgggagc tgtcggaaat ccgaagctgg ttcccgatca 411001 tatatcgtta tgggggctgc tgctgaaaat ccggagggag cttgagcttt ccattaatat 411061 gagacccgcc aaacaaatgg caggcattac gtcgccgctt ctgcatccaa atgattttga 411121 cttcgtggtg attcgcgaga acagtgaagg tgaatacagt gaagttggcg ggcgcattca 411181 cagaggcgat gatgaaatcg ccatccagaa tgccgtgttt acgagaaaag cgacagaacg 411241 tgtcatgcgc tttgccttcg aattggcgaa aaaacggcgc agccatgtga caagcgccac 411301 aaagtctaac ggcatttatc acgcgatgcc gttttgggat gaagtctttc agcagacagc 411361 cgctgattat agcggaatcg aaacatcatc tcagcatatt gatgcgctgg ccgctttttt 411421 tgtgacgcgt ccggaaacgt ttgatgtcat tgtggcgagc aacttgttcg gtgatatttt 411481 aaccgacatc agctcaagcc tgatgggaag catcggcatt gcgccttctg cgaacatcaa 411541 tccatccggc aaatatccgt ccatgtttga accggttcac ggctcagctc ctgacattgc 411601 cggacagggc cttgccaatc cgatcggcca gatttggaca gcgaagctga tgctcgacca 411661 cttcggagag gaagaattgg gggcgaaaat tctggatgta atggagcaag tgactgccga 411721 cggcatcaaa acacgcgaca ttgggggaca aagcacaacg gctgaggtca ctgatgaaat 411781 ctgttcgcgc ttaagaaagc tctgatgaat caggccggtg gcagatggct gccccggcct 411841 gtccatttcc ttacgaaaat ttccacgaaa gtctaaccaa gcagatccaa atgctgtata 411901 ataatttgga attcttagga aagcatcggg tgaaggaagt tgaatgcaaa aacaatcacg 411961 ttaaagaaaa aaagaaaaat caaaacgatc gttgtactca gtatcattat gatcgcagct 412021 ctcattttta cgatcagatt ggtgttttac aagccttttc ttattgaagg atcatcaatg 412081 gccccaacgc ttaaagactc agaaagaatt ctggttgata aagcagtcaa atggactggc 412141 gggtttcaca gaggagacat catagtcatt catgacaaaa agagcggccg ctcatttgtc 412201 aaacgtttaa tcggtttgcc tggtgacagc attaaaatga aaaatgatca gctatacata 412261 aatgataaaa aggtggaaga accatactta aaggaatata aacaggaggt caaagagtcg 412321 ggtgtaacct taacaggtga cttcgaagtt gaggttcctt ccggtaaata ttttgtgatg 412381 ggagataacc gtctcaattc actggatagc agaaacggaa tgggcatgcc ttctgaggac 412441 gatatcatcg gtactgaatc tctcgtcttt tatccattcg gtgagatgag acaggcaaaa 412501 taaaatgcaa tgcaaaaaga acatggaaca tgacggcacc gataataaag cgccgtgcac 412561 gtttaaaaaa atgatgatga aacggtgcgg agccggcttt ccgccccgtt ttttatgata 412621 gaaagcgttt tgaagaaaag ggccctgttg aaataaacag aatcaggatt ggcgaagccg 412681 tgaagcgcat cgaattggta aatctcaaga tgggtatgct gtttttcccg cagttttttg 412741 ataagaagcg ctacgtcaaa cgacggctca taattaggga aaaacaatag gaccgggcag 412801 gctggcatgt gatgaagaga gtcgcgtatc cgggaaccgt aataacaaac cgatccgctc 412861 acctcaggca tactgctgca tttccatgcg atagtagccc ccacgctgaa tccaatcaca 412921 aagatgtgcc gtccggcgtt ttgcctgatc acattctgga tgatggtttc tcccgttttc 412981 agcctttcgt gttttgtaaa ttgttcgtat gccgtttttt cttctttcag tgtgtagact 413041 tcatcctcgc cgagcaggtt gggcgtcaac acatcatatc cagccatttt gatcagccgg 413101 cccatctttt tcatatggct gtttacacca tatatttcgt gtgcgagaat gacaagcggt 413161 tttgggaaca taacggcctc cttttgtgtt ttttccatta tatcctatcg tttcacttta 413221 ggctgagata taatggtcaa aaaaaggaga tataaaatga actcattatc tttgcctcac 413281 cgctatccat ttttgtttat tgatggcgtg acggatagcg agcccggcaa acatgcggca 413341 gcttataagc tgattagtga gaacgactgg tttatcactg atacgcaaac agaaatgccg 413401 ttttcacttg tgattgaagc gcttgcgcaa accgcggctt ttacaggaat tacagatgag 413461 aacagcttgg gattattgtc ttcggtgaag aaagcggaaa agctgggaga agctgtgcct 413521 ggtgaccggc ttgatcttac gtttgaagtc acgcgcaatc ggcgcgggtt tgtgttcgga 413581 catgccaagg catcagttgg agagcagcct gttgctgaag ctgaaatcgg catctatatt 413641 gaaaaatgaa aaaaaccctt cacaacattt tgtgaggggt tctattttgt gtcgtaatcc 413701 cgttcgcttt gagagttatc tctttgctgg cgtttgtgtt tttcatcatt catattttcc 413761 ttcagctctt cattaggaat cggatcggtt aagtcgttgt gctcggggtt ttcatttggt 413821 ttgttttgct gttttttttc tgtcatgttt gatcacctca ccgtttgttt tcctcttatt 413881 cattctcctc aaacatagga aatcgctttt ttgtcccgct gggtataatg tattagaata 413941 gagagaagca caacaaaaag ataaagagag gtacatatat gtctgttcaa agagaagatg 414001 tagatatcaa gctgatcgca attgatatgg atggtacact gctgaacgac gagcagctga 414061 tctcggatga aaaccgcaaa gccattcgtg aagcggagga taaaggtgtg tatgtggtga 414121 tcagcacggg ccggacgctg atgacgtgca gggagctggc ggaatcgcta aagctgtcat 414181 cctttctaat cacggcaaac ggcagtgaaa tttgggattc gaattttaat ttggtggaac 414241 ggaagctgct tcatacggac catattcaaa tgatgtggga tttgcggaat aagcacaaca 414301 ctaatttctg ggcttctacg gtgaataaag tatggagagg cgagtttccg gaaaacatta 414361 cggatcatga atggctcaaa ttcggctttg acatcgagga tgacgatatc cgaaacgaag 414421 tgcttgagga gctgagaaaa aacaaagagc tcgaaatcac aaattcaagt ccgacaaaca 414481 ttgaagtcaa cgcgcttggc atcaacaaag ctgcagccct tgccaaggtt acggaaaaac 414541 tcggctttac aatggagaat gtgatggcga tgggcgacag ccttaatgac attgcgatga 414601 tcaaagaagc gggtcttggc gtcgcaatgg gcaatgcgca agacatcgta aaagaaacgg 414661 ctgattatat cacggataca aatattgagg atggtgtcgc taaagcgatt cgccattggg 414721 tactataaaa aaagagagtc ctaagatgga ctctcttttt tagtttggca ggttttattc 414781 tgggaccatg gtaggttttc tgacaaaagt atttcacaaa ctgatatgat tcacttataa 414841 tgaaataaag ttcaaaaatt cggaatagtc gttccgaatt tcgggacaat aaatgacata 414901 aagcatatcg tttgctttgg caggagggat tctgtgtttc agattgattt aaactgtgat 414961 ttaggagaaa gcttcggagc ctacaagata ggccttgacc aagatatttt agagtatgtg 415021 acatcagcga atatcgcatg cggatttcat gcaggagatc ctagtgttat gcgaaaaacc 415081 gtcgcgcttg cagcagaaag aggcgtgaaa atgggtgcgc atccgggctt gccggattta 415141 ctcggttttg ggcgccgcaa tatggcgatt tctcctgagg aagcgtatga tcttgtcgtt 415201 tatcaaattg gcgcgctctc tggctttcta aaagcagagg gacttcacat gcagcacgtc 415261 aagccgcatg gcgctttata caatatggcg gcagtcgatc aaaaactgtc ggatgctatc 415321 gcgaaagctg tctataaggt tgatcccggc ctgattcttt tcggtcttgc tgagagcgag 415381 cttgtaaaag cgggagaacg gatcggactt cagaccgcaa atgaagtgtt cgccgacaga 415441 acataccaat cggacggcac gctgacaccg cgctcccagc cggacgcact cattgaaagt 415501 gatgatgccg ccgtcaccca ggtcatcaaa atggtgaaag aaggggcggt caaatctcag 415561 caaggacatg atgtgtcatt aaaagcagat acagtctgca ttcatggaga tggagcccat 415621 gcgctgacat ttgcgcaaaa aatcagaaaa cagctcaaag cggctggaat tgaagtgaca 415681 gctatttcag aacagaggtc aacataaagg aggaacaata gatggagcag cagaaaaaga 415741 cagcaggaaa aaaagcgggc agctggtcat tgctgatggg cgccgccttt ttaatggcga 415801 catcagcaat cggaccgggt ttcctcaccc aaaccgcaac attcacaaac acactcgcag 415861 caagcttcgg ttttgtcatc ttaatctcta ttattttaga tattttcgcc caaaccaatg 415921 tgtggcgcat catcgcagtt tctggaaaac gaggtcagga aattgcgaat atggtgcttc 415981 ccggactggg gtatttcatc gccattctcg tcgtgcttgg cggactagct tttaatattg 416041 ggaatatcgg aggggccggg ctgggacttc aggtgctgtt cggcattaca cctgaaacag 416101 gcgctttaat cagtgccgtt atcgccattt tgatttttgt catcaaggaa gcaggaaaag 416161 cgatggaccg ttttacgcaa atcgcggggt tcgtgatgat tattttaacg gtctacgttg 416221 cggcgacgac agctcctccg gtcggacagg cagtcgcaaa tacattcgtc ccggaacaca 416281 tcagcatatt tgccattgtc accctagtgg gcggaaccgt cggcggttat atcacatttg 416341 ccggaggaca ccgtttgctt gatgccggaa ttaaaggaaa ggaatccatt ccgcaggtga 416401 caaagagctc ggttgtcggc attttaatta catctgtcat gcgtatcgct ctttttcttg 416461 cggttctagg cgttgtatcg aaaggcctgc acatcgatga aagcaacccg gcggcttctg 416521 tcttcaagct ggctgctgga aatgtcggtt ataaaatttt cggattgatc atgtggtctg 416581 cggcgattac gtctgttatt ggagcagcct atacatctgt ttcatttttt aaaacctttt 416641 ctccaaaaat tgaaaagaat tcacgcggta ttattatcgg atttattgtg gtttctacgt 416701 tagcttttgt cacaatcggc cagcctgcga agatcctcgt ccttgtcggt tcactgaacg 416761 gcttaattct gccgattgcg ctcggaacgc tgcttgttgc cgcctacaag aaaaacattg 416821 tcggtgatta taagcatccg ctttggctga caagcacagg cgcgcttgta gtgattgtaa 416881 tggcagttat gggaatctac acgttatgta cacaacttcc tcaattgtgg agctgatata 416941 agtggagcaa ttaaacaaaa tggcgccaaa ggatgtacgc gccctgatac gagaggggaa 417001 aataaacggg ccgaccgcag gcatgtccgg cggctacgcc caagcgaatc ttgtggtttt 417061 gaaaaaggac cttgcgtttg attttctgct gttttgccag cgaaatcaaa agccctgccc 417121 cgtgctggat gtgactgaag caggttcgcc tgtgccgtct ctggctgcgc cggatgctga 417181 tatcagaacg gactttccga aataccgtat ttacaggcac ggtatcctaa cggaagaagt 417241 atctgatatt acgccatact gggaggacga ttttgtcggc tttctgatcg gatgcagttt 417301 ctcctttgaa caggcactga tcaataatgg gatagctgtc cggcatattg atgaggggac 417361 aaacgtctca atgtataaaa cgaatatcga ttgtgttccg gcgggggcgt ttcacggaca 417421 gatggttgtc agcatgaggc cggttcctga acggctggct gtacgtgctg cacaagtgac 417481 ctcgcgtttt ccggctgtgc acggagggcc gatccatatt ggcaatccgg gagcaatcgg 417541 gattcgcgat ctcgggaaac cggatttcgg agatgccgtt tccattcgtg acggcgaggt 417601 tcctgttttt tgggcatgcg gagtgacccc gcaagccgtg gctatgaatg taaagcctga 417661 aatggtcatc acacatgcgc cggggcatat gctcatcaca gatattcgag acgagtcgct 417721 tgcggtgctg tagcctctcg tcatcctgat gaacgagaat taaaagaggt gagaaagatg 417781 actgtacgat atcaaatcga acagctcggt gattctgcaa tgatgatccg attcggagaa 417841 gaaatcaatg aacaggtcaa cggcattgtc catgcagcgg ccgcttatat agaagaacag 417901 ccatttccgg gattcattga atgtatcccg gcttttacaa gtctaaccgt attttatgat 417961 atgtatgaag tgtacaagca tttgcctcaa ggcataagct caccttttga gagtgtcaag 418021 cgcgatgtcg aagagcggct ggcagaaata gccgaagact atgaggtcaa ccgccgtatt 418081 gtagaaattc ccgtttgcta tggcggtgaa ttcggtccgg atttagaaga ggtggcgaag 418141 atcaatcaac tgtcaccgga ggaagtaatc gacattcata caaacggtga atatgtggtg 418201 tatatgcttg gcttcgcgcc cggttttcct tttctaggcg ggatgtcaaa acgcattgca 418261 gctccgagaa aatcatcgcc aagaccgtcg attcccgcag gttcggtcgg tattgcggga 418321 ttgcagacag gcgtttatcc gatttcaacg ccgggcggct ggcagctgat cggcaaaacg 418381 ccgctggctc ttttccggcc gcaggaaaac ccgccgacat tgctgcgggc gggagatatt 418441 gtgaaattcg ttcgcatctc agaaaaagac tatcacgcct ataaggagga gtccaattga 418501 gcatgaaagt attaaagccc ggactgctca caacggttca ggatataggc agaacgggtt 418561 accaaaaata cggcgttctg gccagcggcg ctatggacac ggtttcactg cgcattgcca 418621 atctgttgat aggaaacggc gaaaatgaag caggtctcga aataacgatg atggggcccg 418681 gtccgtcgtt tcatttttca aaacagacac tgattgctgt gacaggggcg gacttcacgc 418741 tgcgtattaa tgacgaggaa gcgcctttat ggaagcctgt gctcatcaag gaaaacagca 418801 cggtcagctt tggcccctgc aaactcggca gccgtgctta tttggcggca gctggcggca 418861 ttgaggtgcc tgccgtcatg gaaagtaaaa gcacatacgt cagaggaagc attggcggac 418921 ttcatggcag agcgcttcaa aaagaagatg aactgaacat tggagagatg tcagctcttt 418981 cgcaaaccat cctttctcgc ttaagttcgc agcttggaaa acagggattt gcagcaccga 419041 agtggtcagt cagccgcggc agatttctgc cattgaagaa gaatcccgtc attcgggtgc 419101 tggaaggaaa gcaatttgcc tttttcacag aagaatcaaa aacgcgtttt tatgaagaag 419161 catttcgtgt cacgccgcag tccgaccgta tgggctacag gctcaaagga gaaccgctcg 419221 aactgaaggc cccgcttgag atggtgtcgg aagcggtttc attcggaaca gttcaggtgc 419281 cgcctgacgg caacccgatt atcctgcttg cagaccggca gacgactggc ggctatccga 419341 ggatcgcgca catcatatcc gctgatcttc cgattgtttc ccaaatcatg ccgggcgagc 419401 acgttcagtt tgagcctgtg tccctccagg aggcagaagc gcttgcggta gaacgggaac 419461 agcatataaa agaactgaaa acgagaatga agatggaatg gctgacatag caaaggggat 419521 gaatgatgca gaataaaaat aaaaccgtag tcaaatctat ggcgctgctt aatttgtttt 419581 tgcataaacc aagcctaacc ttaagtgaac tggtgtcgct gacgggaatg ccgaagacct 419641 ctgttcaccg gatggtcagc tccttggagg aaatggggtt cctcagtcgg gatgcgtccg 419701 gcgcttattc gctgggattg gtgtttttgg aattcggaca gcttgtcgct gacaggctgg 419761 atatcagaaa aatagcgaaa ccggtgatgg aagagctgtg ccgggaagtg gatgaggccg 419821 tgcagttgat catgagggac ggcaatgaag cgatatacgt tgagaaaata gaagggacac 419881 agactgtgcg gctgtatacg gcgatcggca ggcgttcccc cctatacgcg ggagcgtgcg 419941 ccagaagcat tctgtccttt cttccccgtg aagaaatcga agcatacatc aaacaaaccg 420001 agctcatttc gattggctcc ggaacgatta ccgatcccga aaaactgctt caggagattg 420061 atgcctctgt gcaaaatggc tatactgtca gctattcaga gctcgaaaac tatacggcgg 420121 cgatcggcgc cccgatcttt aaccatgagc gccaggtggc agccggcatt agcattgcag 420181 gctttgaagc gagatttaca gaagacaggc tgccctattt aacagaaaag gtgaaggacg 420241 ccgctttaca gatttcaaga aaaataggat atacataagt agccaatctt ttctctgctg 420301 cgtacattaa cgtatcgacg ttcaagagtg gaggaaagaa catggtgctt cgatatacag 420361 ctctgggcga ttccttgacg acagggagag gctccgggct gttttcaccc ggcttcgtcc 420421 agcgttttgg ggacatgatg gaagctgact tgaaaacaag aacggcaata aacatatttg 420481 ccagatcagg tctgaataca gaagagattt tgggactcct gtcatatccc tatgtgcaaa 420541 aatgtattcg agatgctgat atgataacga tcacagggtg cggaaacgat ctcatcgatt 420601 cggtcttagc ctaccaaacc tctaaggatg aaacgatttt cagccgtgta tccgcccatt 420661 gccatgagaa ttttgaaaag atgattgcca aagtcgccga gattaaagga gaaaatcctt 420721 ccccgtacgc cattcgtgtg ttcaacttat acaatccgtt tcccgaaatt gatatcgccg 420781 gcaaatggat cacttcgttt aattcacatt tagaaacact tgcatcagca ccccatgtca 420841 aaatcgcgga tgcctatagc atcttcaaag gcaaagaaca ggaatatctg tcctttgacg 420901 gtgtccatcc gaacagcaaa ggctatcaag cgatggctga agccgttcac aagctaggct 420961 ataaagaatt atcagtttca tagaaaacgc gcctcatgac aggcgcgttt tttatgtgtg 421021 atcgaaatat taaaagaaac ttaaaattct ctgtcttctg ttctacagac aaacaaagtg 421081 cgctagaata atggagggcg taggcaaata tagccataac gttcaatatt tcgtatataa 421141 ggaaggatgg tccttttgtt tcggattttt aaaatgtctt ttgcggttat cattattata 421201 ctggcgctta ttgcttttaa ctatacggaa cacacctctg taatccaatc ggtcatgctc 421261 gtctttcttg gtgcggtcat gtttatgcag gggcttgaag agcgcaaaaa agaaaatgac 421321 ggctcaggcg cttttaatat ttataccgcc gtttttgtat ggtctgtctc ccttatcggt 421381 tttacacttc atattatata aatctattac acatcctgaa aatgctcgac cgtcgggaac 421441 ggggtataga accgatgaag caaggctttc cactcttgat actctgaaga accgcgaaag 421501 ccttccgtat ggtcctcaag tgtttcccac tccacaagaa gcagatattt atgcgtttcc 421561 tccatgcatt ttgataacga gtgagtgata tagcccttca tgccggaaat aatcggcgca 421621 gcttgccgga atgcatcctc aaactcttgt tcaaggcctt ctttaatgtg aagcattgct 421681 gcctctctga ccatgctatc ccttctttct gtcttttcaa atagtctaca gcaaacgata 421741 ggagatttct gcaaaatcgg tgaacttttc cttcattttc aaaaaaatct tgcacgcacc 421801 aattcaatta agagaaaata acaagtggaa ggcaggggaa agtcatgtta aaaaagtgta 421861 ttctactagt atttctatgc gtcggattga ttgggttaat cggatgctcc aaaacagatt 421921 caccagagga tcgcatggaa gcattcgtga aacagtggaa cgatcagcaa ttcgatgaca 421981 tgtatcaaag cctgactaaa gatgtcaaaa aagaaatctc caaaaaagat ttcgtcaaca 422041 ggtataaagc catctatgag caggccggcg taaaaaattt gaaagtcact gcgggagaag 422101 tagataagga cgatcaagac aacaagacga tgaaacatat cccgtataaa gtcagcatga 422161 acacaaatgc cggcaaagtc agcttcaaga atactgctgt gctgaaatta gaaaaaacag 422221 atgacgagga gtcatggaat atagattggg acccatcgtt tattttcaag cagctggctg 422281 acgacaaaac cgtgcaaatt atgagcattg aaccgaaacg aggccaaatt tacgataaaa 422341 atggaaaagg cttagccgtc aatacagatg ttccggaaat tggaattgtt cccggagagc 422401 ttggcgataa aaaagagaaa gtcataaaag aactcgccaa aaaacttgat ttgactgaag 422461 acgacatcaa gaaaaagctg gatcaaggct gggtaaaaga cgattcgttt gtgccgctca 422521 aaaaggtcaa gcctgaccag gagaaattag tttctgaagc gacgtcatta caaggcgtaa 422581 caagaacgaa tgtcagctcc cgctactatc cgtatggcga aaagacagcc catttgacag 422641 gctatgtccg cgccattaca gcggaagaac tgaagaaaaa gaaagaagga acgtacagcg 422701 atacgtctaa catcggtatc gccggacttg aaaatgtgta tgaagacaag ctaagaggca 422761 caactggctg gaaaatctac gtgccgcaaa ccggggaagt catcgctgaa aagaaagcaa 422821 aggacggcga ggatcttcac ctcacaattg atatcaaaac gcaaatgaag ctgtatgatg 422881 aactgaagga tgacagcggg gcggcagtcg cgctgcagcc gaagacaggc gaaacactcg 422941 cccttgtcag cgcgccttcc tacgatccaa acggatttat tttcggctgg agcgataagg 423001 aatggaaaaa gctaaacaaa gataaaaaca atccgttttc agcgaaattc aataagacat 423061 acgcgccagg ttctaccatt aaaccgattg cggctgctat tggaatcaaa aacggcaccc 423121 ttaaagccga tgagaagaaa acaatcaaag gcaaggagtg gcaaaaagat tcaagctggg 423181 gcggctattc agtgacacgt gtgtctgaga gacttcaaca agtcgatttg gaaaacgccc 423241 ttattacgtc agacaatatt tattttgccc agaatgcgct tgatatggga gcggacacct 423301 ttacaaaagg cttgaagaca ttcggttttt cagaggacgt tccgtacgaa ttcccgatcc 423361 agaaatcgtc tattgcaaat gacaagcttg attcagacat tttgcttgcg gatacaggct 423421 acggacaagg gcaaatgcaa atgtctccgc ttcacttggc aactgcttac acgccatttg 423481 ttgacaatgg agaccttgtc aaaccgacgc tgatcaaaaa agattcacaa acagctgatg 423541 tttggcacaa gcaagtggtc acgaaggaag gagcggcaga cattacaaaa ggtctgaaag 423601 gcgttgtgga agatgagcgc ggatcagcgt atcagcctgt cgtgaaagga atcacagtgg 423661 ctggaaaaac aggaacagcc gagctgaaaa catcaaaaga tgataaagac ggcacggaaa 423721 atggctggtt tgtcggctac gattacgaaa acaaagacct gcttgtcgcc atgatgatcc 423781 aaaatgtgca ggaccgcggc ggcagccact atgtcgttga gaaagcgaaa aagcaatttc 423841 aatcgaatta aaatgtcttt ttaaaaggag cgaaaggaaa aaggggatct gaggccgaat 423901 gaactagtaa gggggcaaaa cccggtttat acaaagaaaa gagggatttt gcatgcagcg 423961 tattcaattg gcggaggatc ttcaattttc aagagtcata cacgggcttt ggcggctgaa 424021 tgaatggaac tattcagatg ctgaacttct aagcctcatt gaatggtgta tcgatcacgg 424081 catcacgacc tttgatcatg cggatattta tggaggctat acgtgcgaaa agctgtttgg 424141 aaacgccctt gccctttcgc ctggattaag agaaaacata gagttggtca caaaatgcgg 424201 tatcgttctt gaatcgcctg aacggcccgc tcacagatcg catcattata acacaagcaa 424261 atcgcatatt ttggcatccg ttgagcaatc gcttatgaac cttaggacgg attatatcga 424321 tatgcttttg attcacagac cggacccgct catggatccg gagggggtag cagaggcgtt 424381 tcaggccttg aaatgctctg gcaaggtcag gtactttggc gtttcaaatt ttaaagatca 424441 ccagtatcgg atgctggaat catatttgcc tgagaagctc gtaaccaacc agattgagct 424501 ttccgcatac gaattagaaa atatgctcga cggcactttg aacctgtgcc aggaaaaacg 424561 gattccgccg atggcttggt cgcctctggc aggcggcaaa gtattcactg aaaacacgga 424621 taaagaccga cgtgtccgta cggcgcttga atccgtccaa ggggaaatcg gcgccgcttc 424681 attggacgag gtgatgtacg catggctgta tacgcatccg gccggcatca tgccgattgt 424741 cggaagcgga aagcgcgagc ggatttccgc cgcgataaat gcgttgtcat acaagcttga 424801 ccaggatcaa tggttccgca tttttacagc cgtacagggt tacgatattc cataaaaagc 424861 atcagtttac cagctgatgc tttttcaata ttgtcacacc gcttagtgcc aaattaccat 424921 ttataagtga ttgattcttt cttgaaagcg ttttatatta aaaggaaacc tctctatatc 424981 ctctactgca tctccttgcg acttcatccg cacatcaaga ttggctagga ggtctttttt 425041 atgtatatga ctgccagaga acaaaagctg ttaaagcact tattattaca aaacagatat 425101 ataaccgtaa ctgagcttgc tgagctgatg caagtcagca cgagaaccat tcacagggaa 425161 ctcaaatcaa ttaaaccgct gatggaaacc gtggggctta cgttagataa acagcccggt 425221 aaagggttga aagcagtggg aagtcccgag ggtaaacaaa agctgcttac tgatttatca 425281 tatgaacagc atgaatacag cgccgacgaa cggaaactgc tcattctttg ttcgttatta 425341 gagtctcagg agcccgtcaa actgtacacg cttgctcatg atctccaggt gacgaatgcc 425401 acggtcagct atgacttaga tgagctcgag aagtggattt ctccctttgg actgacactg 425461 atccgcaaaa gaggttttgg catccagctc atagggccgg agaatgcgaa acggaaaatt 425521 gtcggcaact tgattgtgaa ccgtctcgac atccaaatgt ttttggaagc ggttgaatta 425581 aacatcaaag gaaaaaccga ttcttcagag aaaatgttcg gggttgtcag caaaggtgag 425641 ctgttaaaaa tggagcgcat cttatttcag ctcaaagaaa aaatcgcttt ttcattgtcc 425701 gacagctcct atatagcgct cgtcgtccat ctgacgtatg cgatcgaacg aattaagctt 425761 ggggaaacta tcaccatgga gcaaaatgag cttgaggaac tgatgaatgc gaaggaatac 425821 agctccgctc ttgaaatcgc gggcgagctt gaacgtgcct tcggcgtgac gattccagag 425881 gcggaggtcg gctatattac aatccatctt cgaagcgcca atcgaaaata caaaacagaa 425941 tacaaagcgc aggaaattga gctggaaaca gccctgcaaa caaagcggct cattgctttt 426001 atttcagaca aaatcagaat ggatctgacg aaaaactact ctttatatga aggcttgatt 426061 gcccatttgg agccggccgt cagccgcata aaagaaaata ttgagatata caatccgatg 426121 aaggaacaga tcaagcgcga ttattttctg ctttatatgg cgatcgaaga aggtgtcgaa 426181 aagtattttc cgggcatgtc cttttctgat gatgaaatcg cttttatcgt tcttcacttt 426241 ggctcggctc ttgaaatcaa aaaagaagaa gcaaaagtga aagcgcttgt cgtctgctca 426301 agcgggatcg gctcctcgaa aatgcttgcc tccagactga aaaaagagct gccggaaatt 426361 gaatcgtttg atatgtcatc tctgatcgag ctaaagggga aggatgttca agcctatgat 426421 atgattgtgt ccactgtacc gattccttat gaaaacattg attacatcat ggtcagccca 426481 ctattaaatg aggaagacgc aaaccaggtc aagcagtata tcaagcggaa gattcccctt 426541 attcttaaca aaaaaagaag ctcgaaggaa gaggcgcagc aagctgatgt acctgacatg 426601 ctggaggcgg cggaaagcat agggcggtat atggaagtta tccaagatgt tctgcgccat 426661 tttacgctag ctcaactcaa aacaaacccg gaccatagca tgcttctgct agagcttttt 426721 caacagctga agaaggatgg cctgatccgt gatccggaaa aagccgcggt ttgcctggct 426781 gagcgggaga aacaaggggg attgggaatc cccggaacaa acatggcgct ttatcatctc 426841 aaaaatgatg aaatcgtcct gccttttttc aaaatgtttg atctcagcac cccctatgaa 426901 gtggatggca tggacggaaa taccctcagg atgacacgca ttctcgtcat gatggcgcct 426961 ggctcattat ctgctgaagg ctcggagatt ttaagcgcga tcagctcggc aattatcgag 427021 agcggagaaa gcatggcggg gtttcaggaa gaaggaggac aagaattgta tcagcggtta 427081 aaccgcatat ttttcacatg gatgaaagaa aaaaacatac tgtaaacctg catggcacac 427141 gtcaaaaatt tggcgtgtgt ttttctgtgg atggggaaca aaataagaaa atgtgggact 427201 attttatcat tcagtattgg aataattcca aaatgaaata gttttacaag ttatcttttt 427261 tgggttaaaa tgggtgaggt aaggaagaaa atctaacaaa ttattgaaga ttcaagagaa 427321 tataggagat gacgatatgg aaacattaca gcatctgatt ctgcatgaca tgccgaatag 427381 cgaagaaata gaggctgtaa aaagcggaga ccatacactg acatataaag gttaccgtaa 427441 acggattaat cagctggcga atgccatgct tcaaaaagga attcaaaagg gcgaccgtgt 427501 tgcattgctt tgcaaaaacg gccatcccgc ctcaactgtt atgttcgccg cacttgaaat 427561 aggtgctgtt gtcgtacctg tcagctggca gctgaaacca tatgaaatga caggcatttt 427621 aaaagcaagt gaaccaaaag cgatgtttta cggagcggag tttaaagaga tactggatga 427681 agttcttcct gaattgtcct cactgtgtgt aacaatggaa acaggaacag cttacgaaac 427741 atctgctgaa tttgaagcgc tgtttgcagg tcctgatcat ttgccagaga cggaaatggt 427801 ttcacctgat gatacagcac ttctgatgtt tacatctgga acaacgggaa acccgaaaag 427861 atgcatgatt acacatggcg gcatatacag atacgttaaa aaatccaaca gctcaatagc 427921 acgtatgaag ggccttcgtt ttctcgcgtg ccatccgatt tatcatacga gtgcgctcat 427981 ttgcatcatg cttggaacgt ttgcagaaac aacatttgtg tttacaaagg atcaagatcc 428041 tgttcacatg ctgaaggtca ttgaagaaga gaagattcag accgtgatgg ctcttcctgt 428101 gttctacacg tatttgcttg aggcgtggga aaagcaccaa actgacttat cttcgcttgt 428161 tattttaatg acaggcggaa caaaagtgcc gagcagccta ataagccgct atcttgatat 428221 tggcattccg cttgcgcatg gctatggaag tactgaggct tggggcatca gcacatggac 428281 gcctgatatg ggaatggata aagcggcatc tgcaggaaaa cctgtggcag gtgttaaagt 428341 caaagtggaa gatcctctga ccggagaaga acttcctcaa ggagaaatcg gcgaaatcgt 428401 tgttcatact ccattcttat ttaaaggcta tgaagacaat cctgaagcaa cagcgaaagt 428461 gctgcaaaat ggatggttta gaaccggaga ttcaggatat gtagatgaag atggctttat 428521 tttcatcacg ggacgctaca aggatgtcat tatttacgga ggcgataacg tctatcctga 428581 tcaggttgaa gaagttatcc agcagatccc gggaatcctt gaaacggctg tggtcggtat 428641 tcctgacccg ctttacggtg aaaaaccgaa agcttttatc gtgaaaaatg gcggccagcg 428701 catcacggaa gaggatgtca tcgcattttg taaagaacgc ctgtccgctt acaaaatacc 428761 tgaagttgaa tttgttaacg aactgccgaa aaacaacctt ggcaaggtga aaaaagacgt 428821 cctgcgcaat caggctgtac attcataaaa gaagaagccc gtccacttta tgtggcgggc 428881 ttctttgcag ttgcacagac ggaaagctca ggcttaatgt tcttaaattg tatatcaatg 428941 tcttcgaagc cggctgcttt aaagtcagca atcatctgtc ttccaaatga tttggttttc 429001 tcaggactgg catccgcttc ccgcggctgc atcgtaatgg ctgctttgcc gcctggcttt 429061 aatgcccgat aaatctgttt tatgcctttt gtttggtcat tccaaatggt gtagttgtta 429121 acggaaatca ctttatcata aaacgaggcg gggagaggaa atgtctcgat gcttccttgt 429181 atcaggcgta cgccctttgg tttcactctg cgggcggcca gcttcagcat ggcctctgat 429241 acatcaatcc catgaagatg aacatccttc tcgcgtttca gcatctgctg catgcagtat 429301 cccgggccaa acccgacttc taaaatgctg tccccgcgcg tgatacccag ctgattgatt 429361 gtccactgat tcagtgtttg attttcagca gccatgatgt acccggcaat catgccgatg 429421 acgccctttg gcctgctgaa tcttctagaa agcatgttaa tcattcagca accaaccccc 429481 tttttgagtt aatttcctct cagcgttcca tgtgaaacat ttttctgata aagcaatgcg 429541 aaggtgccaa gccatgttta tccaaagagt gtgtgaggta cacaacaaat agacatgaaa 429601 acaaaggagg agaatcatca tggcaaatta tccaaaagaa ctgccggcac aaactcaaag 429661 tcgccagccg ggaattgaaa gcgaaatgaa tccaagtccg gtgtatgagt acgaggatta 429721 taaaggagca gacaaattaa aaggaaaagt agctcttatt acaggcggcg acagcgggat 429781 cggacgcgcg gtttccgtcg cttacgcaaa ggaaggcgca gacatcgcca ttgtgtataa 429841 ggatgagcat gaagacgctg aggagacgaa gaaacgtgtt gaacaagaag gcgtaaaatg 429901 cctgctgatt gctggtgacg taggtgaaga ggaattctgc aatgaagcgg ttgaaaaaac 429961 ggtcaaggaa ctaggcggcc ttgacatcct tgtcaacaat gcaggtgaac agcacccgaa 430021 ggaaagcatc aaagatatta cgagcgaaca gcttcaccgc acattcaaaa caaattttta 430081 ttctcaattt tatttgacta aaaaagcaat tgattacctg aaaccgggca gcgccatcat 430141 caatacgaca tccatcaacc cgtacgtagg gaacccgaca ctgattgatt atacagcgac 430201 aaaaggggcg atcaatgcct ttacaagaac aatggcgcag gcgcttgtca aagacggcat 430261 ccgtgtaaat gcagtcgcgc cgggtccaat ttggacgcca ctaatcccag ctacgttccc 430321 tgaagaaaca gttgctcaat ttgggcaaga tacgccgatg ggccgtcctg gacagcctgt 430381 tgagcacgtc ggctgttatg tgcttctggc atcagatgag tcctcttaca tgacaggtca 430441 gaccctgcat gtcaacggcg gaaactttgt gacgacataa gagggagtga gacatatggg 430501 catcacgaaa gaagaagtga acagctacta tcaaaaagca gggattgtat taacggacga 430561 ggaagtagac caaatccagc tgatggatta cggcttagga aaagaaagaa aagtcgggct 430621 ccagctcttc gtctacgtca atacagaccg ttattgttca aaggaattgg tgctgtttcc 430681 gggacagact tgcccggaac accgccatcc accggtcgac ggccaggaag gcaagcagga 430741 gaccttccgc tgccgctacg gaaaagtgta tctttacgta gaaggagaaa aaacgccgct 430801 tccaaaagtt ctccctcctc aggaagacag agaacactat acggtctggc acgaaattga 430861 gctagaaccg ggcgggcaat acacgattcc accaaacaca aagcattggt tccaggccgg 430921 ggaagaaggt gccgtcgtga cggaaatgtc atcgacgagc acggataaac atgatatctt 430981 taccgatcca agaatataag gatgggctta acagcccatc ctttttgtat tgaaaaaaac 431041 agaatcatcg ctataatggg taaaaaagga aagagggcga ggcaatgttc acttgcaagg 431101 taaatgagca catcaccatc cgattattgg agccgaagga tgcggagcgg ctggccgaac 431161 tcattatcca aaatcagcag cggcttggca agtggctgtt ttttgcggaa aatccaagca 431221 gcgctgacac gtaccgagaa acaatcattc cagattggcg gcgccagtat gccgacctga 431281 acggcattga ggcgggtctc ctttatgacg gcagcctatg cggcatgatc agcctgcata 431341 accttgatca agtgaatcgt aaggcggaaa tcggatattg gattgccaaa gaatttgaag 431401 ggaaaggcat tattacagct gcctgccgaa aactcattac gtatgctttt gaagagcttg 431461 agctgaatcg tgtggcgatc tgtgcggctg tcggaaacga aaaaagcaga gcggttccgg 431521 agcggatcgg gtttctagag gaaggaaagg cacgggatgg cttatacgta aacggcatgc 431581 atcacgacct cgtctactac agtctgttaa agcgtgaatg ggaaggcgaa aaataaagag 431641 cacactttct tgtttaaatc ttccccggat gtggaaaagt aacagcggag acgttaaaaa 431701 ggagtgattc gagatgaatc agcaagacat taaacaaaaa gtgcttgatg ttctagatca 431761 ccataaagta ggttcgctcg caacagttca aaagggcaaa ccgcattccc gctacatgac 431821 ttttttccat gacgggctga cgatttacac accgacaagc aaggaaactc ataaagcgga 431881 agaaattgag aacaacccca atgtccacat tttattaggc tatgattgtg aaggttttgg 431941 cgacgcatat gtcgaagttg ccggaaaagc aaagatcaac aattcggcag aactcaagga 432001 caaaatatgg agttccaaat tagagcgctg gtttgacggc aaggatgatc cgaatctggt 432061 gattcttgaa attgaaccgg aggatatcag attaatgaat gccggggaga aaacaccggt 432121 ctcactcgaa ctataaaaaa tttgtgtttt caggggcgat atgttattat gaatagctag 432181 taagaaaaat aagcaaataa aaaagaaagt aaacttcttt tttctgtttt gagagagaag 432241 cttaccgctt cccaagcagc ataaccagct gcccttattc ttttccttca taacaaatcg 432301 cccctaacga tgagatggaa aaaagacttt tttgttttac aattcacacc ggcgcggctt 432361 cggagccgca gtgacgattg agaggtaggg ctttcgttgt cttgtgttca agaaatttcc 432421 atggtgttta ctttccagaa tgattcttcg gaacaatgct ttatgaatct aacccgcctg 432481 acttggcgga tgatataatc tttatttgcg tatagaaaag aataagacaa accgcccggc 432541 gtacgccgga cggttttttt attgcaaaaa acacatcgta ctgaaacctc cttgtcttct 432601 ttccagtctt atctctagga tgaaattgga ggaagaataa cgtgcatgtc attacaacac 432661 aagtactttt tattttttgt tttttattgc tgattcactc gatagaaacc ttagcctatg 432721 cgacaaggct ttccggagct cgcgttggat ttattgcgtc cgcgctttct ctgtttaatg 432781 tcatggtcat cgtatccaga atgtcgaata tggtgcagca gccctttact gggcatttaa 432841 ttgatgatgc tggaaaaaac gcactggcga ttgtagggga gcagttccgc tttttaattt 432901 tcggatcgac agtcggcacc attttgggca ttatcctgct cccgtctttt gtcgctcttt 432961 tttcacgggc gattattcac ttggcgggcg gcggcggctc cgtttttcaa gtattccgaa 433021 agggattctc gaaacaagga ttcaaaaatg ccctttccta tttgcgtctg ccgtccattt 433081 catatgtaaa aggatttcat atgcgcttga ttccgaagcg tttgtttgtc atcaacatgc 433141 tgatcacatc gatttatacg attggtgtgc tttcggcttt atacgcaggc cttttggcgc 433201 cggagcgcag cacgacagcc gtcatggctt cgggtttgat caacggaatt gcaacgatgc 433261 tgctggctat ttttgttgat cctaaggtat ccgttcttgc tgatgatgtg gcaaaaggaa 433321 aacgaagcta tatctattta aaatggacct ctgtcacaat ggtcacatca agggtggcgg 433381 gcacactcct cgcccagctc atgtttattc ccggggccta ctatatcgcg tggctgacaa 433441 agtggtttta ataagaaagg ctggatcata aagatccagc ctttttgcgc ttccttattt 433501 atagttcctt aatccgcggt cgtacaaaaa atttccgaat gggacgaaag cggcgatgaa 433561 gccggcagct gaccatttca gcggccattt gacagagaag gttgcataag ccaagacaag 433621 caaatacaaa atgaacaacc cgccgtgaac cgaaccgaca attgtcaccg caagcggaag 433681 gcctgcccaa tatttaagcg gcatagcgat gaacaacagg attaagagtg acattccttc 433741 aataaaaccc atcgtgcgaa gtcttccgat cggcgtgtgc agcataaatc gccctccttg 433801 tggacacgtt ttcattttat actataaaca atccgggggg gcatatgaca gctttcaaaa 433861 aatgttcgga aaacattcat ttttacatgc cttttctagg gaactgtact tgtcatttac 433921 aaaaataccc gagataatgt gtacaaaatc aaaaaagaag gatgttgaaa tgaaacttga 433981 ccagattgat ctgaatatca ttgaggagct gaagaaggac agccgtttgt cgatgaggga 434041 attaggcaga aaaattaagc tgtcgcctcc atctgtaaca gaacgggtaa gacagcttga 434101 atcgtttggc atcatcaagc aatacacgct ggaggtcgac cagaaaaaac tggggcttcc 434161 cgtttcctgc attgtggaag caaccgttaa aaacgcggat tatgagcggt tcaaaagcta 434221 tattcaaaca ttgccgaata ttgaattttg ctaccggatt gcgggtgcag cctgctatat 434281 gctgaaaatc aatgccgaaa gcctcgaagc ggtagaagat ttcattaaca aaacatcgcc 434341 ctacgcgcaa accgtcactc acgtcatttt ctcagaaatt gacacgaaaa acgggcgcgg 434401 ttagagagtg ccgcgcgaag tctgttataa taacaggatg agcgtgaaag aaagagaagt 434461 gatcaagcat gtcaaaaaca gttgtattag ctgaaaaacc ttcagtcggc cgggatttag 434521 cccgggtact gaagtgccat aaaaaaggaa acggttatct cgaaggcgat caatatattg 434581 tgacttgggc tttaggccat ttggtgacgc ttgctgatcc ggaaggctac ggaaaagaat 434641 ttcaatcatg gcgcctagag gatctgccga ttatcccaga acccttgaag cttgtggtga 434701 taaaaaaaac cggaaagcag ttcaatgcag tcaaatccca gcttacccgt aaagacgtca 434761 atcagattgt catcgcgact gacgcaggcc gggaaggtga gcttgttgcg cgctggatca 434821 ttgagaaagc gaatgtccga aaaccaatca agcggctgtg gatttcatct gtgacggata 434881 aagcgatcaa ggaaggtttt caaaagctgc gcagcggcaa agaatatgaa aacctgtacc 434941 attctgccgt cgccagagcg gaagcggatt ggattgtggg gatcaacgcc acccgtgcac 435001 ttaccacaaa attcaatgcc cagctctcat gcgggcgtgt gcagactccg acgcttgcca 435061 tgattgcaaa gcgcgaggca gacattcagg cgtttacgcc cgttccgtat tacggcatac 435121 gtgctgcagt cgacggcatg acgctgacgt ggcaggataa gaaatcaaag cagacgagaa 435181 cgttcaatca agatgtaaca agccgtttgc taaaaaatct ccaaggaaag caagcggtcg 435241 tagctgagct gaaaaaaaca gcgaaaaaaa gctttgcgcc tgcgctttat gatttaacgg 435301 agctccagcg tgacgcccac aagcgcttcg gtttttctgc caaagaaacg ctttctgtcc 435361 tgcagaagct atatgagcag cataagctcg tcacatatcc gcggacggac tctagatttt 435421 tatccagtga catcgtcccg acgttaaaag accgtctgga aggcatggaa gtaaaaccgt 435481 atgcccaata tgtcagccaa attaaaaaac gcggcattaa atctcataaa ggatatgtca 435541 atgacgcgaa ggtgtcagac caccacgcga ttatcccgac cgaagagccg ctcgttctca 435601 gcagtctgag tgataaagaa cgaaagctgt atgacctgat tgcgaaacgt ttcctggctg 435661 tattaatgcc tgcattcgaa tatgaggaaa caaaggtcat cgcagaaatc ggcggagaaa 435721 cctttacggc gaaaggcaaa accgtgcagt cgcaagggtg gaaagccgtt tatgatatgg 435781 cggaagagga tgatgagcag gaggatgaca gagatcagac acttcctgcg cttcaaaaag 435841 gcgacacact tgccgtccgc acgttaacgg aaacaagcgg ccaaacgaag ccgcctgccc 435901 gctttaatga agggaccttg ctgtcagcga tggaaaaccc aagcgcgttt atgcagggag 435961 aagaaaaagg cctcgtcaaa acgcttggag aaacaggcgg cctcggcacg gtggcaacgc 436021 gtgccgacat tattgaaaaa ctgttcaaca gctttttaat cgagaaaaaa ggccaagata 436081 tttttatcac atctaaagga aaacagctcc tgcagcttgt tccggaggat ctgaaatcac 436141 cggccttaac agcagaatgg gagcaaaagc tgtctgcgat cgcggccggc aaattgaaat 436201 cggctgtttt tattaaagat atgaaggctt acgctcacca aacggtaaaa gaaatcaaaa 436261 acagcagcca aaccttccga catgacaaca ttacgggaac ggcatgtccg gaatgcggca 436321 aaatgatgct gaaagtaaac ggcaaacgcg ggacgatgct cgtgtgccaa gatcgtgaat 436381 gcggaagcag aaaaacgatt gcccgaaaaa caaacgcacg ctgcccaaat tgccataaaa 436441 gaatggagct tcgcggccaa ggcgagggcc aaacctttgc gtgtgtgtgc ggtcaccgtg 436501 aaaagctctc tgtatttgaa aaacgaaaaa acaaagacaa agcgcgtgct accaaacggg 436561 acgtatcctc ttatatgaaa aaacaaaata aagatgagcc gattaacaac gcgctggcag 436621 aacagctgaa aaaactcggt ttggataaat aataaaaaaa cctgtgccta tcgcacaggt 436681 tttttattgg acttaggtcc tgttttctta atgttcaaaa agggaaaaaa aagctagcaa 436741 tctgcatttt ttttctttta tagtaaatgt actttgtaac atggcagtca tattttcgtc 436801 tataactatt tgtgagcgtc tgatttgctt caggcgacaa agggggattt gcctgtgagg 436861 catgtactaa ttgctgtcat cttattcttc ttatctatcg gactttccgc agggtgtgct 436921 gaagctggaa acaagaccca aaatcagtcg gcgacagaag tgaatgccag cccgctccag 436981 ccggcggaat atttcatcta tcacaattta atgaatgaca aagggctgat caaaaccgat 437041 ttttcagacc agccttctta cttgtcggaa tctctcggac tgtggatgga gtttctgctc 437101 agcaaaaatg acgcaccaca tttccaggat caatatcagc atctgactga ttcatttctg 437161 atgagcaatc acttggtgac gtggaagatt caaaatggcc aagcgagcgg gacgaatgcg 437221 ctgatagatg atatgagaat tatgctgtct cttgaccaag ccgccgcaaa atggggccgc 437281 agcgactacg cgcaaacggc tagggatatc ggcacgtctt tgaagacata caatatgaac 437341 aacgggtttt ttacagactt ttacgactca caggccgctt caaaggatgt gacgctttca 437401 tacgtcatgc ctgatgcctt agctgtctta aagaagaatg gaatcataga cgaagaaaca 437461 gaacagcgga atgccaatgt tctctattca gctcctttaa aaaatggctt tctgccgaag 437521 acatacagct cggagacgaa ggaatacaca tatgatagtg aaatcaacct gattgatcag 437581 ctttacgctg cttggcattt gccggaaggg gatgaaaaag catctgtttt agcggactgg 437641 atcaagcagg aatttcagaa aaacggaaag ctgtacgggc ggtattcggc atatacgaag 437701 gagcctgccg tccaatatga gtctccatcc gtatatgcct tagccgtatt gtttttgaca 437761 aaacagcatg aaaacagttc tgtcatcaaa gccatatatg atagaatgaa tgactttgaa 437821 attcatgatc cggtgaaatc gtattatgga ggctatatga gcggcactca gacgcattca 437881 tttgacaatc tgctgccgct gttagccgaa aggaagcttt ttaatgaaaa tatcattcag 437941 tgaatcacaa aaattatttg cttatttttc agggctcatc gcggccctgt ctttgtttat 438001 ttattatgtg tcagcccagc aatcagaagg tgctctgatc ctttgcatca catttggcgt 438061 catcgccgca ggcatctggt tcggcccgat ttacgcgctg gcagtgacct taatcgtact 438121 ctttgttctc ggcaccttaa tgatgttttt ccagactgga cagacatcgc tctttccggc 438181 tgaggaaggg ctgcgaatgc ttgtcgtgtg gggaatcgcg cttttgctgt tttcttttat 438241 ttctggaaga atccacgata ttacagcaga gcttcggcgc tcaatgacac ggcttcaatc 438301 cgaaattaaa agctatgttg ctgttgacag agtgactggt tttgataaca agcaaaggat 438361 gaagctggaa ctttcagaag aaatcaagcg ggcggagcgc tacggcaatt cttttgtgtt 438421 tttgctgctc catatgcatt atttcaaaga gtttaagtct ttgtacggtg aaaaagaaac 438481 ggaccgcctc ttccaatatg tcggtcagca aatcaggaca agcgttcggg aaacggataa 438541 gaaattccgt ccctctgacg agcgtatcgg gatcgtgctg acgcacacgc ctgctgaaca 438601 tatgccggcc gttctgacta agctgaagaa acaattggat acatatcagc tggaaaatgg 438661 aaagtatgtg tcgcttacgt tccacgtttg ctatttgccc taccgcaacg atatccaaac 438721 agctgatcaa tttttagaag aactggaaaa cgagatgatg atgaatgaac tataaaggaa 438781 tcacattgct atgcgtcatg atgcttctat tttcagctat tgcgtctttt cccgtttctg 438841 cgcaagcgaa agatcaggat gccggcattc tcatcatcta ctcaaccttg gacggcaaag 438901 agtcgtcaca agtcaaaatg ctcgatttgc ttgcgggcca ctttacatcc catgtgacag 438961 tcaaaaaaga ttcagacgtt gaagcgtcgg atttcaaagg gaaagaccat gtgatttatt 439021 acggccaaac gaaaagaaag ctcagccaaa aattgctgtc tcttatcagc ggcgtgaaaa 439081 aaccggttgt cgccattggc tataacgcag gccaaatcag ccaattttct gggctttcat 439141 tagcccgcaa agaaaatgtg tttcaggttc acagcaggtc agaaaaggcc gatgtgtctc 439201 tggaaagcgg gcttaacgtg ctgagtgtat caggcctgaa aggaacggcg ctttacacct 439261 tcaaagcgga tgaaggcaca acgcattctt ttatatggaa aacaaaaaaa gggaatgtgt 439321 acattggatt aacaaatttg ttaaatgaca atttgatcgt ggcgaaacag ctcagagaag 439381 ctttcggaga gaaggcgggg acgacgttat tgtatttgcg tctcgaggat atcagcccga 439441 tgtctgatga aaaactgctg cttcaagccg gtacatacct gcataagcgg catattcctt 439501 ttatcctggc ggtcattccg gtttacttga atccggaaac aggcgacaaa gtgtatttgt 439561 ctaatcaacc gaagatggtc aaggtgctga agaagctgca aagcatgggc ggcagtatca 439621 tagttcacgg ctatactcac gcttatcgct acagtgaaac aggagaggga tttgaatttt 439681 gggatgcaaa ggcggatcag ccgattacat ccggaaatgc cgaagacccc ccgtccattt 439741 tggagaaaga acaggacttc ccgaacgaac aagcctatca cagctatctt gaaccatttc 439801 gggaaaagga agaaacgtat acaaaacaaa aactgacgcg tgccattgag gatttgacat 439861 catcgggtct ttacccgctg gcgtttgaag cgccgcatta cacgatgtcc gaatatggct 439921 atcaaatcgc ctcgcagtat tttacaagca ttttcggcca ggtccagctc agcagcacaa 439981 catggaaaac atccggtgca cctccgtttg tgactgctcc ttcgatgctg cacggaatga 440041 cgctttatcc ggaaacgatc ggctttgtcg acacatcgaa gcaaaacccg ctcggtgaga 440101 tggaggagca tatctcccag atgattgatt ttgaaggcgg agtagccgga ggattttatc 440161 acccgtacct tgggatgaaa tatctgcctg agctggttga tcagatggaa cgcattccag 440221 acagtgaatg gcttgattta aagaaaacga aacaaaccgt caaaacagac aaagtggaaa 440281 ttcatacaag cggtgacgga acgattcagg tgaaaaacgg cgtaagcccc atttacgagt 440341 ttttcgatca tcaccggcaa acccctctgg aaaaggcgtt atggattctc tccgctgttg 440401 tgctcttatt tgtcatcatg tttgtcagtt atacgtttta cttgagagcc acattgaaaa 440461 aacgaatttt taaggagaga agaagccttg ggtaatacgc tgttctttat ctcgctaagt 440521 ttaatatggg ttatgcttct ctaccacatg ttcctcatgc agggcgggtt tcgccactat 440581 atgaccttcg aacggaatat cccgaagtgg agagaaaata tgaaggaact gccgaaggtc 440641 agcgtcctca tcccggcgca taacgaagag gttgtgattc ggcagacgct gaaggccatg 440701 gtcaaccttt attatccgaa ggaccggctg gagattatcg tcgttaatga taattcatca 440761 gaccggacgg gtgatatcgt caatgaattt tccgagaaat acgatttcat caaaatggtg 440821 attacgaagc cgccaaatgc aggaaaagga aaatcctctg cacttaactc gggttttgcc 440881 gaatcgaacg gcgatgtgat ctgtgtgtat gacgccgaca acacgcctga gaaaatggcc 440941 gtgtattacc tcgtgctcgg cctgatgaat gacgaaaagg caggcgccgt ggtagggaaa 441001 ttccgcgtca tcaatgcggc aaagacgctg ctgacgaggt ttattaatat cgaaacgatc 441061 tgttttcagt ggatggccca gggaggcaga tggaagtggt tcaaaatcgc cacgatccca 441121 ggcaccaact tcgcgatccg cagaagcatt atcgaaaagc tcggaggctg ggatgacaaa 441181 gcgctcgctg aggatactga gctgaccatc cgggtatata atctcggcta tcacatccgc 441241 tttttccctg ccgccatcac gtgggagcag gaaccggaaa catggaaggt atggtggcgc 441301 cagcgcaccc gatgggcgcg cggcaatcaa tatgtcgtgc tcaaattttt ggcgcagttt 441361 tttaagctga aacgaaaacg gattatcttt gatttgtttt attttttctt tacgtacttc 441421 ctgtttttct ttggcgtgat catgtcaaat gcgatttttg tagtgaattt gttttatgat 441481 ttgcatttgt ctgttggatt tttggcaatg attctctgga ttttggcgtt tttcttattt 441541 atgacagagg tcatgattac gttgagcatt gaaaaaacag aaatgaacaa gcaaaacttt 441601 tttatcgtat ttctcatgta cttcacatac tcgcaggcat ggattgtgct tgttatctac 441661 tctttattcg tagaaatcaa gcaccgttta ttcaagcaag aggtcaaatg gtacaagaca 441721 gaacgataca atcaacataa aagcgggtga cctttttgaa acaaataatg atttttctca 441781 caagcttcat gctgctggcg atgactggac aaacggctct tgccaaagac gtacaggtca 441841 gcggttcgct ccttgggaaa agcagccaag aacaagccaa acagcaggtg ctgacaagcg 441901 agctgattac actgtatgga tcaaaagaca gcgcagagct gacgtatcag atcccggcag 441961 gcgcctcttc gggcaatcag caattggtaa tcgaatacga ggcatcaaat cttttaattt 442021 ctccatcatc gttaacggtt gtcattgatg atgaaccggt caagacgtta aagcttgatg 442081 gtgattccaa acggaaaaca gtgaagctga atctgaataa aagccagtct gcgcaaggct 442141 atcacaacgt atcgctgaaa ttctacggcg taatgaaaga gggcgtgtgc gtcagacagg 442201 atacatcagg caactggatc aaaatttatc cggacagccg gctgacactt gctgacagca 442261 gtgaagcgaa gggaacgtcg ctggaccatt atccgtatcc tttcgcccaa tctggaaata 442321 cagcggaaga aacagctatc gtcattccgg ataacccaag ttcagcagaa atagaagctg 442381 ctgttaaaac agaaggctat ttgaaaacgg tggacagcag tgtcagtatt gcgtatgtca 442441 cggaatctga actgaaaaaa atcgataagc cgacgattgt tatcggcgtg gacaagcatt 442501 ggaacggcaa agtgaaaaaa ctgttgaaac aagccgggct acaggcaaaa ggagaaaacc 442561 ttctgcttgc ggagcgggtg ctgaaagcag agggcaaaca gcagccggtt ctgtttgcgc 442621 aagcggcgtc cgaggacgcg ctcacaaaaa aaatcagcgt gatgacagat cagacatata 442681 caggccagct cagcggcgat acactttcaa tcagcaagct tcagcagact gaaaaaaaag 442741 aaagcgataa gctgaccctt gagaattttg gagcgggtga tatcacaatt ggagccgaca 442801 aaacatcttc agcacattat ttttatccgg cttcggctgt tttagatgaa aaccaatcgg 442861 cgaagctgtc gcttaaactg aaaaagtctg aaacgattca agcctcaacg gctgaaaacg 442921 agtcagcctc tcaggctgca gaactgaaag tgatgatcaa cggccagccg cactcggtcc 442981 ggcttgatga attaggaaaa gaagataaaa acggattcta tcatgtcaca gtgaaagtgg 443041 accctaagct gctgcaaaaa aaccgctaca ttgatattca gttcgtcacg accggtttaa 443101 aggaaaacaa cccttgtaac accactgatg aagaaaagtg ggtttttatc gataaaaaca 443161 gtacattatc atacgccatc aaaggcatgt ccccgtcagc ggattttcaa gagtggccgc 443221 tgccttacgc cggaaaccag gatcaaacaa cgttaatcgt gcttcctgac accgtaagcc 443281 aatcgaagct agaggagctt tctctcgtaa cagaatcctt tggcaacgaa gcacagcatt 443341 catatacggt aaagaaatca tctgacgtta cagcaaatga tgcgaaagga cgaaacctca 443401 ttttcatagg agggatcaat caattttctc ttctgaagga gaaatcatca gatctgcttg 443461 tgccgcagga aaagaacggc tcgtttgatg tatctagttt cgagatgctg aatgagacga 443521 caaaacaagt ggtatttacc caagcatcgg tttgggattc acgctataca atggctgtct 443581 ttgcaccgtc aaaaggagat ggcacggctg tcacaaaaga gatcatcagt tatctgaaca 443641 gcaacgatga gtcggcaacc gtccttaatg aaacaaacag ccagcaggtg tttacaaacc 443701 accagcagct caaatcggaa acaaacagtt ccgatgcaga acaaccaaca caggatcata 443761 gccagaaatg gatgtatatt ggtgtgctgg cactcattat ggtggttgcg gcagtgttca 443821 tttggattgc cgtaagacgc aaaaaaagaa agacagatac agaataaaac agaggcgatt 443881 ttagcctctg tttttttatt tttggtaagt aaattccatt tgtggaacct gtcattttat 443941 ttttttctct cagccaataa gcctctttac aacgtgcggg aacgggagta tgatctcttt 444001 tagaaaacaa atcgcttaat ctgaaatcag agcgggggac ccaatagaac ggctttttgc 444061 cgttggggtg aatccttttt aggtagggct aactctcata tgcccgaatc cgtcagctaa 444121 cctcgtaagc gttcgtgaga ggagatgaat gaaacctgtg ttcgatgtta tggcacaggg 444181 gcatccgttt gcctctgtgt tttttgttgt tcatttttga atgcaaatcg catacagaga 444241 catcatagca gaaaggacta tcatcaacat gtgagagcaa gacactgatg gatgttttat 444301 tgttttaatt gaaaaatgag aaattaaaag gggaagacat cgatgtatca ttcaatcaaa 444361 cgttttttga ttgggaaacc actaaaatcc caagcagctg gagagcaaaa actgacgaaa 444421 ttaaaagcct tggctatgct ttcctcagat gcgctgtcat ctgtcgcata tgggacagaa 444481 caaattctaa tcattttggc aacaatcagt gcagccgcat tttggtactc cattccgatt 444541 gcggttggcg ttctcatctt gctgctcgca ctgattcttt catacaggca aattatttac 444601 gcttatccgc agggcggcgg ggcgtatatc gtttctaaag aaaatctcgg tgaaaaaccg 444661 ggattgattg cgggcggttc attgcttgtt gattatattt taacagtagc ggtaagtatt 444721 tccgcaggca cggatgccat cacgtcagcc tttcctgcat tgcatgatta tcatgtgccg 444781 atcgctattt ttctcgtgtt agtgattatg attttgaacc tgcgcgggct ttcggaatca 444841 gcatccatac ttgcctaccc ggtttatctg tttgtggtgg cgcttttggt tctcattgca 444901 gtcgggttgt ttaaacttat gacaggacaa atagaccagc cagcccatca tacatcgctc 444961 ggcacacctg tagccggcat tacgctattt ttgctgctta aggctttttc ctccggatgc 445021 tcagcgttga ccggggttga ggccatttct aatgcgattc ctgcattcaa aaacccgcct 445081 gcgcgaaacg cggcaagaac gcttgcgatg atggggattt tgctggcgat tctgttttcc 445141 ggcatcacgg ttctcgcgta cgggtatggt acggcgccga aacctgatga aacagtggtt 445201 tcacaaattg cgtccgaaac ctttgggcgg aatgtgttct actatgtcat ccaaggtgtc 445261 acatcgctta ttttggttct tgcggcaaat acgggattct cagccttccc gcagcttgcc 445321 ttcaacctgg cgagagacca gtatatgccg cgaatgttta cagtcagggg cgaccgctta 445381 ggcttctcaa atgggattat ctttttaggc tttgcctcca ttgttctcat tatcttattc 445441 gggggacaga cggagcactt aatcccgtta tatgctgtgg gcgtatttat tccatttacg 445501 ctttcacaaa ccggcatgtg catgaaatgg atcaagcaaa aaccaaaagg ctggatcgga 445561 aaaatgctga tcaactcctg cggcgctctg atatcattta tggttctatc cattctgttt 445621 gtgacgaagt ttaatgtcgt atggcctgtg ttaatcttta tgcctatcgt cgttttgctg 445681 ttttttgcga ttaaaaatca ctatactgcg gttggtgaac agcttcgcat cgtagacaaa 445741 gagccggaag aaatcaaagg caccgttgtg attgtgcctg tggccggtgt caccaccgtc 445801 gtgcaaaaat cgattcacta tgcgaaatca ctgtccgatc aggtgatcgc cgttcacgtg 445861 tcatttgaca gagaacagga aaagaaattc gaaaaacgtt gggaagagct taataacgga 445921 gtgcgtctcg tgacgcttca ctcctcttac agaagccttg tccatccgtt tgataagttt 445981 ttggaaacag ttgaggcaaa agcgaagaag gagcagtttt ccgttatggt gctgtttccg 446041 caatttataa cgaaaaaacg ctggcacacc atccttcaca accaatcggc cttcctcctc 446101 agagtccggc tgttctggaa aaaggacata atggttgcca cactgccgta tcattttaaa 446161 aagtaaagct ctaggaccaa gggaatcacc ttggtccttt ttagcgggaa aaggaggtat 446221 gggggtgtat acacaaggtg cttttgtgat cgtattgaac gaaagtcagc aaattctgct 446281 ggtgaaacga aaagatgtcc ctctatggga tttgccgggc ggcagggttg atcccgggga 446341 atcggctgag gaagcggcag tgcgggagat attggaagaa acgggataca atgcagcgct 446401 ttctgcgaaa ataggtgttt accaaaggcc aaagtttcaa gatgaacagc atctgttttt 446461 cggaagcatt acaggcggac aagcaatggc tgacggcaca gagacagcgg gattaaagtg 446521 ggtttccccg gggcgtttgc cgctttttat ggtgccgaat cgaaaaaggc agatcaatga 446581 tttcaagaac ggcgctcaag atgtaaatgt caccgtcaag gatagcgggt tgctcgcggc 446641 gatcgacctg ttgaaaagaa gactgggcaa gtgattcagg tctccgggtt ttaaagcctt 446701 tctcctgtgg tattgaaaaa aggaaaaagg aggatacgtt atggcacaca aaactgcagg 446761 acaagcaatg acagagctgc ttgagcaatg gggagttgat catgtatacg gcatccccgg 446821 agacagtata aatgagttta tcgaagaatt aagacacgaa agaaatcaac tgaagttcat 446881 tcaaacccgc cacgaagagg tagcggcact ggcagccgcg gctgaagcaa aactcaccgg 446941 caagatcgga gtctgtctgt caatcgcagg gccgggagcg gtgcacttat taaatggttt 447001 atatgatgct aaagccgacg gcgcccctgt gctggcgatt gcaggacagg tttcttctgg 447061 cgaagtcgga cgggactatt tccaggagat taagctggag caaatgtttg aggacgtggc 447121 cgtgttcaac agagaggtac atagcgcgga atcacttccg gatctcttaa atcaggcgat 447181 caggaccgcc tacagcaaaa aaggcgttgc ggtattgagc gtgtcagatg atttgtttgc 447241 ggagaaaatc aaacgggagc ccgtgtatac ttcaccggtg tatattgaag ggaacctaga 447301 accgaaaaaa gaacagctcg tcacctgcgc ccaatatatt aataacgcta agaaaccgat 447361 tatcctggca gggcagggaa tgaaaaaggc gaaacgggag ctcttagaat ttgcggacaa 447421 agccgccgct ccgatcgttg ttacactccc ggcaaagggt gttgttcccg ataagcaccc 447481 acattttctc ggcaacctcg gtcagatcgg aacaaagccg gcttacgagg caatggagga 447541 atgtgattta ttaatcatgc tcggaacgtc attcccgtac cgtgattatt tgcctgatga 447601 cacgccggcg atacagctcg attcagaccc ggcaaaaatc ggaaaacggt atccggtgac 447661 agcgggcctt gtctgtgatt cggctctcgg tttgcgcgaa ttgacagagt atattgaacg 447721 caaggaagac agaagattcc tgaatgcctg cacagaacat atgcagcatt ggtggaacga 447781 aattgaaaaa gatgagacag aggcaacaac accgcttaaa cctcagcagg tcgtggcccg 447841 tcttcaggaa gcggcagccg atgatgcggt gctctctgta gatgtcggca ctgtgacagt 447901 ctggatggcg cgtcatttca aaatgaacgc gaatcaggat ttcatcgttt ccagctggct 447961 tgcgacaatg ggctgcggcc tgccgggagc gattgcagcg agcttgtccg aaccggaacg 448021 ccaggcgatc gccgtctgcg gtgacggggg attttccatg gtcatgcagg accttccgac 448081 cgccgttaaa tataagctcc cgatcacagt cgttatttta aacaacgaaa atctcggcat 448141 gattgagtac gagcagcagg tcaaaggcaa tatcgactat gtcacaaaac ttcaaaatgt 448201 cgactatgcc gcatttgcag aaagctgcgg agcaaagggc atcaaagtga ccaaagcgga 448261 agagcttgcg ccggcttttc atgaggcgct gcactctgac caaccggtcg tagtggatgt 448321 catgattgga aacgaaccgc cgcttcctgg caaaatcacc tacgggcagg cgaaaggctt 448381 tagcaagtac atgctgaaaa acttcttcga aaaccaaaaa tttgaaatgc cgtcactgaa 448441 gaaaagtttg aaacggttat tttaaaaaaa caggggccct aagagccctt gttttttttt 448501 ttttttttgg aaacaaatgt attttcagca tgtttgaatt cataaaatga tcggtatatg 448561 tattaggaac tgatttcgcc atactcgaaa cagacaaaag gacaaatgca tcttgtttca 448621 aaggaagatg catttgtcct tgcatgctta ttcttatcaa atcttacaga actcttctca 448681 taataggtta tttttctttt ttcttcagcc cgaagaagaa aggaaaagca gaaccgacca 448741 agaaggtgcc gaataaaaac atgccgccga taaacacgtg gaaatttgtg tgtccggccg 448801 taaacgccgt gattagggaa atgatactga gcacgatcat ggcaatgccg ggcgcgactc 448861 tcatttttcc cttggattta tgggcagcaa cagaacataa aatgccgata acaataggaa 448921 caatccacaa ataaaacaga ataaatactg acatcatcaa aactccgatt tttcttctat 448981 cataacaaat ttctgtcaaa aagggtatca atgagctttt gcggaaaaat aaaaaccggc 449041 tttagaagcc ggttttttta tcgaaacgta tctacaatta aaaacacatt caaagcaacg 449101 atcaatacag caatcagcca agacaccact gtgatccatt tggcgttgat cagagatccc 449161 atgatccgtt tattgcttgt aaacataata agcggaatga gggcaaaggc gatcccgaag 449221 gacagcacga cctggctcag tacgagagcg gtcgtcggat taacacctga cgcgatgatc 449281 aagatcggcg gaatgatcgt gataaaacgc cgtacataca gcggaatgcg gtagttgata 449341 aatccttgca taatcacgtc gcctgaaagt gtgccgacag acgaactgga tagaccggca 449401 acgagcagcc cgatcccgaa caaagccgca gacatagggc tgacaagatg tccgaattgc 449461 tgaaatgcga cgtcgagatc ctcaacaaac aggccgtttt tgaagaataa tgcggcagcc 449521 acaatcagca tacttgcatt aatagcccct gcaatcagca tcgctattaa aatatcaata 449581 aattcaaacc taaagatttt tttccgttct gcatcagttt tgccaaccac ccgccgctgt 449641 gtaagggcag agtgtaaata aatggcgtgc ggcataacag ttgcgccaag aatacccgct 449701 gcaagaagca cactgtcggt gccatgaaac gccgggacaa aaaggccctt catcactgac 449761 acggcatcag gctttgcgaa aaaggtctgc aacgcaaagg cgatcacgac cacaaacagc 449821 ataccggcaa tacctgcttc aagtgagcga taaccacggc gctgaagctc caatatcgcg 449881 aaagaaccga tcgccgcaat aatagacgct tcaagcatcg gaatgccgaa cagcaaatac 449941 agtcccagag ccgctccgat aaattccgcc agatcagttg cgataatgac caactcgccc 450001 tgaatccata atccgatcga gacaggcttc gggaattctt cacgggcaac ctcaggcaga 450061 tttttgcctg tcgcaatacc gagtttggcg gatagggatt gaattaaaag cgccatgata 450121 ttggaaaata agatcaccca taagagcata tatccgtatt tagaacccgc cgaaatattc 450181 gttgcgaagt tgccgggatc aatataggca atggctgcta taaatgcagg gccgagaaaa 450241 gggagcagcc ctctgaatcc tctgattttc ccgtcaagcg catcttggac ggctttggaa 450301 cggggagatt gtgctgtgat gtccttgttc atcatgtctc acctgaattc tgtttgtttt 450361 tgccgtacaa caaagagttt ccttaaggca aattatttta tctacatcat atgaccatcc 450421 cggtttcttg tcaaccgaaa atgttcaaaa tacacttctg aatttttccc tgttatgtaa 450481 catgatatgt agggattcgt gataaggtcc catataaaaa gacatcgttt catttcgaaa 450541 cgatgcctcc tgtatctaat gagtctaggc ttccttccgc agcccgcgga atataaggcc 450601 cagcaagaac acgaagatgg ctgccccgat gatggccggg aaaatagcaa agccggcgag 450661 gctcggtccc catgtgccaa gaagtccgtg cccaatccaa gcgccgatca gcccggcaat 450721 catagagccg aaaattcctc ccggcagccg gtttcctaca atggcgctcc caattaatcc 450781 gataacaatt gcaacaacta atgaaaccaa aaagctaagc atcatgatca cctctcataa 450841 atgatttacc aatcaataac cgctcctgat catttcgaaa cacttgaaag catattcctt 450901 tatgatcctg ttttaatctt tctctgcaca ctgccgtcag ctaaatgaac aatgacctca 450961 gtgcctttat gcgccgcgat ttcctttgcc cgttcaatcg cttctttctt tgtatccttg 451021 atttcagaca cacgtttggc gccctcggct ttgactgccc agcctttttt atgcttaata 451081 acatgctctg ctttattcat gagctcgggg ccgctgccgc tgcttggatc agcatcgcgt 451141 tctgtctcat catcatgcgt caggaaatca tcaatttcat ctgtagaggc gttttccgcc 451201 cattccttcg ctttgcttgt cgcaattgga atcgcgcgcc cttcctcata gccttcatca 451261 atcatcgcat tcgcaatgtc tatcgccttt tttctcaccg gcttctcaag attttttaat 451321 gaagcaggat aatccttcat cgaccaaggc atgtctatca ctccttttcc ttttataaaa 451381 atggtacccg caggtgaaaa ataaaaacgc atccgaaaaa atgaaggtat actatatagt 451441 agaaaaaacg gaagggaagt gcgggttggg tgccaacaga acgaaaagaa gacttacatc 451501 agcaattaaa agagatagag aaatgggaaa aagatcagca aaaagtctgg ttttgggaaa 451561 agctcagccg tctcccgttt caactcctgg acaagctgac accagaattc atccagaaaa 451621 agatcggcaa gctcttggat gaggtcggca gctttgttca aacaggcgga cagtacctga 451681 catctgaaaa acagattatc aggatgtttc aaaagaaact gccggaggag atctttgaat 451741 cgctggagga catccggaaa gcgcctcttc ctgtcatgga tgaaattgcg gaaggaatgg 451801 gcaaaaacag aaccaacgca gcaaccgttc aaggcgcgac aaccggtgtg ggcggcgtgt 451861 ttacgctggc ggcagacatt ccggcagtgc ttggcttatc actaaaaaca ttacaggata 451921 tcgcagtcgc atacggctat gacccaaagg agaaaaaaga acgagtcttc attgtgaaat 451981 gcctgcagct tacgtcggct gatgttgtcg gcaaaagatc gattttgcag gaattaaaac 452041 actacgatca agaccgtaca tataagaatg tcgcttctca aatccaaggc tggcgagaag 452101 tcgttttggg ctatcgagac acgtttggct ggaaaaaact tttccagata gtgccggttg 452161 ccggaatggt ttttggcgcc gctgccaatc gctcaacatt aaacgacatt accgagacag 452221 gcatgatgct gtacaaaaag aggcgcattc ttgaacgact gaaagaaaca gaacgagaga 452281 tggaatagca gaaagcagac ggacaccgcg atccgcctgc tttttttagt ggaaacatac 452341 ccaatgtgtt ttgtttgttt aaaagaattg tgagcgggaa tacaacaacc aacaccaatt 452401 aaaggaggaa ttcaaaatgg cagacaataa caaaatgagc agagaagaag caggtagaaa 452461 aggcggagaa acaacaagca agaaccatga caaagaattc tatcaagaga ttggtcaaaa 452521 aggcggagaa gccactagca aaaaccatga caaagaattc tatcaggaaa tcggcgaaaa 452581 aggcggagaa gccactagca agaaccatga caaagagttc tatcaagaaa tcggtgaaaa 452641 aggcggagaa gccactagcg aaaatcatga caaagaattc tatcaagaaa tcggccgaaa 452701 aggcggagag gcaacaagca aaaatcatga taaagaattc taccaagaaa ttggctcaaa 452761 aggcggaaac gcccgcaaca acgactaatc aaaagcataa aggcagacaa cctgtaaata 452821 aaaaagcgat ccggcacatc agctggatcg cttttttttg gaatcttctc aatttatgcc 452881 gctattgaga tacaataagt gaaaaagggg ttttcgctaa tgtccaagat gcaaaacttg 452941 ctcgccatcg caaatgaagt caaagaaaag cacgccaatt tttcaatctc agaggtcaac 453001 gaccactgcg tgcgccttgc ggtgtttacg ggagaatatg actggcacca tcaccctgac 453061 tcagacgaat tgtttattgt tcttgaaggg gagctgctga tcgattttaa ggacaaagaa 453121 accgcggtgc tcaaagcaaa tgacagcctg ctgatcccta aaggcacggt tcaccgcaca 453181 cgctcttacg tcagaacggt aaatctctgt gtggagcata aacaagccga aaccgtcatc 453241 atagaggagc agccatgcta atcaaaaaga tgatatgtga agtagatgct gcaaacgctg 453301 aagcatttgc aaaagcgcag tcacagtggg aagcgttatc gcatataagc ggctttatca 453361 aacaggccgg cggctggcga aaaacgatag acgagccgct caccgcagaa atcatcagtg 453421 tatgggaaaa cagagaagcc tatgatcatt ttatggagaa cgaacatgac agcatatacg 453481 aggaaaacga tcagaaggct gtaattcttt cgatagaggt gacggtgtac gaagaggata 453541 aaccgttcgt tcacgatctg ttacataacc ccgatatccg gtacgaacca aactggacgg 453601 ttctgaaggc ataatcaaag cccaaaacat catgttttgg gcttgtctct ttactcgcgt 453661 cccggaagtg tattatgaac aaaaggcggt gctggtttta actccggttt ttctccaaac 453721 gtttttgctt ctttcacata ttcaaaggct tctccgtccg gcgctttttc attcagccag 453781 ttttgctcgg cgcttacttc gccttcagag aaattgataa gctgatgtga gaactcttgt 453841 ttttcgagcg ctttcgggaa tgtacccggc acaaccggac cttcctgtgc ttctaattct 453901 ttaatggcgg cgagccattg gttctggtgc atcgtgtcac gcgccagcag gaagctgagc 453961 atatctttga cgcctttgtc atccgtcatt tcaaacaggc gtgcgacctg cagacggccc 454021 tgagattccg cattcaggtt ggcgcggaag tctgccagca ggtttccgct tgctacgata 454081 taaccgccgc tccaaggtac gcctgtactg ctttccggca tggcgccaag tcctgataca 454141 atcgcatggt gagggttcat gccgcctagg atggagccga tgaccggatc ttcagcagct 454201 ttttcctgct gatcaagagg ggcatcctca agaagtctgg caatcatcgt tgcgatcatt 454261 tcaacatgcc cgagctcctc agttgccgta tccatcagca agtccttgta tttttcattt 454321 cctcttgtgt tccagccttg aaataagtac tgcatggcaa ctgaaatttc tccgaattgc 454381 ccgcctaaaa tttcttgcat ttttttagcg aataatggat ctggacgatc tggtttagca 454441 ggatgctgca gcatttttgt gtgcttaaac atgtacccat ctcctttttc gtttatctct 454501 ttttatattt ccgatcgata gaaagataaa cgaaaaacag cgtatcgaga tgggaactat 454561 gaatcttttc gcagctccaa cagttcccgg atcagctccc ggccaaagat gggctcatac 454621 tgccggtaaa cagggtcaag acgcttcatc cattcttgtt tctctttatc tgacagctca 454681 taaatatgta tagcagaatt ctttttgatt tcttccagct gctccttgtt catttgttcg 454741 gcatacgttt cattccactc cgttgtctcc ttcatcgctt cagtcaaaat gcgtcttgtt 454801 tctggtgttt gcgccttcca gaagtgttca tcagtcatga cagcgtagcc gagataaccg 454861 tggctgctta ttgtcaaata gtcctgaaca ttataaaatt ttttagaata gatgtttgaa 454921 attgtatttt cttcgccatc gactacattg ttttctaaca gctgaaaggt agaattgaag 454981 gattcctgat gaggtgttgc gccaagcagc ttgaactgat cctcaatcac atcgctttgc 455041 ataatgcgca gatcctgccc ttttaagtca tccggtgttt tgaccggccc ttgatttgtt 455101 gtgatttgct taaagccgtt cgtccaatag gccaatcctt tcaattggtt tttctttaga 455161 gaatcaaaca gctgtgtgcc gatgcttccg ttcagccctt ttttgacggc gttgtaatct 455221 gtaaatgcat acggcagatc cagcactccc cattcaggcg agagcatgcc gagcttcgat 455281 gtggaggggg cgataaattg aacatcgccg ttttgcaatg cttcaatttc ttcaatgtcc 455341 gagtacaggc ttccattcgg aaatacttct atttttattt ttccgcctga tttttcgttc 455401 accagatcag cgaatttatt ggcggccagc ccttttggcg tattttcagc aaccacgtgg 455461 ctgaatttaa acacgatttg atcctgcagg ccttcctggt cgtcatcata aacaatcttt 455521 ttattgccgg tatgatcatg gaatccgata aataaagcgg ttgcaattcc agcgatcatc 455581 agtgcgagac atgcaagcaa actcttcatg aaaagccctc ccctatgtta aggataatgg 455641 gggctatgac attcgtaaag acctgaaagg agaagctgat gaacaaaaag aagctctcaa 455701 tccgttggaa aatcacgatc ttatcctata tactcgtcat tttctccttt ttgatcggcg 455761 gcattgtgct catcggcaac attcagcata cagaggagcg ggagctgaaa aagcggctga 455821 tgaatacggc ccggacggtg tcagagatga cagaagtgaa agaagccttg gcgcgaaaaa 455881 aacaaacaga agcggttcgc catgcggttg aagaaatcag gatgattaat gaagcagact 455941 atattgtcgt catggatatg aatcacatcc gatatacgca tcctgtcagc acaagcattg 456001 gcaagaaatc agaaggtgca gacgaggagg cagcttttgc ggagcacatt tatttctctg 456061 aagcaaaggg cgagatcggc acggcggttc gcgcttttta tccggtaaag gatcaagacc 456121 tgaaccaaat aggcgtggtg cttgtcggaa aaacgctgcc ggggatcgct gacatcctgc 456181 ttcatttaaa gcgtgatatc gccttcatcg ttgtgctgac actcggcttt ggccttgctg 456241 gttccttttt gctggcccgc catatcaaaa aacaaatgtt tcagcttgaa ccccatgaga 456301 ttgtccgaat gtatgaagaa cggacagcga cgtttcactc gatgaatgaa ggggtgatcg 456361 ctattgacaa tcgtctcgtc attacgatct tcaatgaaaa agcgaaacag atctttgaag 456421 tgcaggggga tctaatcggc aaggtgattt gggaggttct caaggattcg cgcctgcccg 456481 aaatcgtgga gcggaacaaa gcggtttata atgaagaaat tcgtgtcagc ggtaaggtga 456541 tcatgagcag cagaattccg atcgtcatga agaaaaaagt gatcggcgcc gttgcgattt 456601 ttcaggacag aacggaagcg gccaagatgg cagaggaatt gactggtgtc agaaactttg 456661 tggaggcgct ccgtgtccaa aaccatgagc atatgaataa gctgcacacg atcgccggtc 456721 tcatccagct ggggaaatct gaaaaagcct tgcagcttgc attccaggcg tcaactgagc 456781 aggaaaatgt gactgaattt ctgcaccgct cgattcaaaa tgacgctgcg gcaggccttc 456841 tattaagtaa aatcagaagg ggaagagagc tcggcattgc tgttcatata gatgaaaaca 456901 gcagtcttca gcaatttccc gagcatgttg atcagcatga tattgtcgtg cttttgggga 456961 atctgattga aaatgccttc ggctcatttg aaaccgttca atctgaagac aaacgaattg 457021 acattagtat cgaacaaaca gatgatatcc ttgctatttt aatagaagat aacggctgcg 457081 gaattgaacc gacacatatg cctcgccttt atgacaaagg ttttacggtc aataaaactg 457141 gcggcacagg ctatggcctg tatctagtga aacaaatcat agacaaagga tcgggcacga 457201 tagaagttga ttcacatgcg gggcagggga catctttttc tatcgttttt ccaatgaagg 457261 gggaggaagc acagcatggc tcgtaaagaa tggaaggttc tgctcattga agacgatccg 457321 atggttcaag aggtcaataa ggatttcatt acaactgtta aaggcgttac tgtctgtgca 457381 acggcaggaa acggagagga aggcatgaag ctgattaaag aagaacagcc agatctcgtc 457441 attctcgatg tgtacatgcc gaaaaaagac ggcatcaaga ccttgcagga gatcagaaag 457501 caaaagcttg aagtggatgt cattgtcgtc tccgctgcaa aagacaagga aacgatctca 457561 ctcatgctgc aaaacggggc ggttgactat atcttaaagc cgtttaagct tgagcgaatg 457621 agacaggcac tcgaaaagta caagcaatat aaacaaaaaa tcgaagcgaa tgatacgctg 457681 tcccaggaac agctcgatgc gatcctgaat attccgcagc aggccgtaca ggatctgccg 457741 aaagggttga atcacttcac gatgaatgaa gtcactgctt ttttgaaaca gcaaaccgca 457801 tccctttctg ctgaagaggt tgccaaggcg ctcggcatcg ccagagtgac agccagacga 457861 tatcttgatt acttagaaaa aaccgggatc atcaaattgg acgttcaata cggcggagtc 457921 ggccggccgg tcaaccgcta cgtgttaaaa ggataaacct gagaccaaaa agaccaaaat 457981 gtccgttatg atcataaact tccccagact gtatgaaaac gctatcattc tagtaagaaa 458041 gacacaaaag gcgaatagga cagggggatg aaggatatga aactgtttaa aaatttaaca 458101 gttcaggtca taaccgcggt catcatcggg gtcattgtcg ggctggtctg gccggatgtc 458161 ggcaaagaaa tgaaaccgct tggtgataca tttatcaacg ctgttaaaat ggtgatcgca 458221 ccaatcattt tcttcacaat cgttctcggg attgcaaaaa tgggcgatat gaagaaggtt 458281 ggaaaagtag ggggaaaagc gtttatctat ttcgaggttg tcaccaccct cgcactcatt 458341 atcggtttat ttgtcgtcaa tattatgaag ccgggtgcgg gtcttgatta cagcaagctt 458401 gaaaaaggag atgtatcaca atacacgcaa aatggcggtc agggaatcga ctggattgaa 458461 tttattacac acattgttcc gtccaacatg gttgatgcct tcgcaaaagg ggacattttg 458521 caggtcttat tcttttctat tcttttcgga gtgggtcttg cggcattagg cgaaaaagga 458581 aaaagcgtca ttgatttctt cgacaaggtt tctcacgttt ttttcaaaat tatcggctac 458641 attatgcgtg ccgcgccaat cggggcattc ggggcgatgg cgtatacaat cggacacttc 458701 gggctcgatt ccatcaaacc gctggcaagc ttaatgatgt ctgtttatat tacgatgttc 458761 ctgttcgtat ttgttgcttt aaatatcatc tgcaagcttt acggattcag cctgtggaat 458821 taccttcgct tcattaagga tgagcttttg atcgtgcttg gcacaagctc ttccgaatcg 458881 gtgcttccgc gtatgatgga taaaatggag cgctacggct gttccaaatc cgttgtcggg 458941 cttgttattc cgacgggcta ttcgtttaac ctcgacggca catccatcta tttatcaatg 459001 gcgactgtct ttttggcaca ggtgtttgga gtagacctca gcatcggcca gcaaattacg 459061 attatcctcg ttctgatgct gacatcgaag ggagcggcag gtgtgacggg aagcggattt 459121 atcgtccttg cctcaacgct gtcagcgctg caggtcattc cgctggaggg gcttgcactc 459181 ctgctcgggg tcgaccgttt catgagtgaa ggaagagcca ttgtgaacct gatcggaaac 459241 ggaatcgcca cgatcattgt tgccaaaagc gaaaatgaat ttgatgaagc aaaaagcata 459301 gaggctgttg aaggcatgaa aaaaatgaaa acagcagtct gaaaaaagaa cggcccatcc 459361 atgggccgtt tttttaattg tttaagaatt attaaggtaa ggacagagac ctcagcattt 459421 ttttgttata taatttacaa atggatacta tattgaatga aggacgtttg tcctaacagg 459481 agtgtataaa tggccgcttt agttaaattt tttcagcacc cgggagtaag gcgtttctcc 459541 atctttgtcg tgttaactgg tgtgttatat ctatttaaga gcatgatcaa cttaatattg 459601 cttaccttca ttttcacatt tctaatggat cgtttggagc ttgtcgtgcg gcagtttgta 459661 agccagttct tccgcgtgag ccagcgggtt gtcattacgt ttctttacat gttgctggct 459721 gtgctgctta cagtcggggg ctttgtgttt tatccggtcg tcgcggcgca gatccagcag 459781 ctggtaaagc agattaaaca tattgcgtat catcctgaca gcatcccttt ctttgatgag 459841 atcaccagtg tcttcggaga tattaacatc agttcatatg tcaaagaggg cttcaatgta 459901 gtgtatacgt atctggccga tatcagcaca ttcggcttgc aggtcgtgat ggcgctcatt 459961 cttagcatgt ttttcttatt tgagaaaaaa cggctttctg aattcatggc gaaatttaaa 460021 acgagcaaac ttagggtctt ttatgaggag attgcttttt tcggaagcaa atttgcaaga 460081 acgttcggca aggtgctcga ggctcaattt atcattgcgc tcgtcaactg tattctgacg 460141 tttatcgcgc tttggattat gcattttccg cagctgtttg ggctttcgat tatggtgttc 460201 ttccttggat tgatccctgt agcaggcgtc gtcatttccc tgattccgct cagcattatc 460261 gcctacagca ctggcggtgg aatgtatgtg ctctacattg tccttgtcat attcgccatt 460321 catgcgatcg aaacctattt cttaaatccg aagctgatgt cggcgaaaac agagctgcca 460381 atctttttca ccttcacagt actcattttc tctgaacact tcttcggcat ttggggttta 460441 attatcggga ttccgatctt tgtgtttctc cttgatattc tggatgtcac caacaaggaa 460501 gataggtcta aaggaccccg agagaatagc gataaaaagt agtttaaaat cgaataatga 460561 gtgtgcctcg atctgccggc ctgcctgttc agggcatgga attaagactc ggaatcggag 460621 cttggcattg ccttgcacag tggtgaacac aacaggtgac aatgcttgtc atcagtacgg 460681 aaactgaaaa gaacaaacag tcggagcaaa cgctcatcat cggtttaacc aaacatttgg 460741 aagcaacaaa tgctataata caaacagtgc ctaatgttgg gcactgttta ttttttgtcg 460801 aaaaaggagg aaggctttat ggctgagccg attttacata ttgaaggcct cgataaaaaa 460861 attgggtcta aacagatttt aaaacagatc agcatggacg tcatggaggg tgaaatcatc 460921 ggccttctcg gtccgaatgg ttccggaaaa acaacactca tccgtatcat cgtcgggctg 460981 ttgaaacaaa acagcggaag cgtgacaatc agcggattcc agcatgatac agagtttgaa 461041 aaagcgatgg aagcggttgg agcgattgtt gagaaccctg agttctatcc gtacctgaca 461101 ggctgggaaa acctcaagca ctttgcgaat atgcacaaaa aaatagcgga tgaacggctt 461161 gatgaagtgg tggaacgtgt cgggctgacg tcagcgattc atgataaggt gaaaacctat 461221 tcccttggga tgcgccagcg tctgggaatc gcccaggcaa ttcttcaccg gccgaagctt 461281 ctcattctag atgaaccgac aaacggcctc gatcctgcgg ggatgaagga ttttcgggat 461341 catattaagg aactcgcaga aatggaagga acagctgtcc tgttcgccac tcatttattg 461401 cgcgaggttg aagacttgtg cgaccgtgtc atcatcattc aaaaaggtga gatcaaagcg 461461 gaagtcagct tacaaggaac cgatcaaacc acagaaaaag cgattataga agtgcagccg 461521 caagaaaaag cgctcaattg gctgacaggc aatcaatatc aagctgagag ccaagacggg 461581 acgattgtag ttgaggtggc aaaagaaaac ataccggagc tgaaccgatc acttgtcgga 461641 caagatctga atgtattttc cattacgcct tacacgcagt cactggaaga cgaatttata 461701 aaagcgacaa cagctcatca agaggaggga gaagagcttg tctaaattaa tttggaatga 461761 acatatgaaa ctttttaatc ggaaggtcac tttggtttct cttatcctga tggctgtctt 461821 tcaattcttc atggcattga tcattaaacg gattgtcatc agtgccggaa cagatgaaaa 461881 cttcatcggc tatttatcgt atacaccgag cctgaacatt ttgctgcagg ctttaacgat 461941 cgtaattgca gcaacaattg tttcgatgga atttgataaa aagacgatca aatttttgct 462001 cattcgtccg gttaaacgcc aaaaggtctt ttggtcaaaa ttaatcacag tcgtgatggt 462061 cagcttctat ttgtatttgg catactacat tctggcatta ttattcggtc tcttgttttt 462121 tggcacatcg gtgactgcgg aatcaaagac attgctggtc aacaccttgg cgctgatcgg 462181 gtcaaactgg cttgaagctg taatgatggg attattcggg ctgctttgtt cttcgctgtt 462241 ccgcaatagc gcggtagcag ttgttgtttc ttttgtcgtt ttatacggag cgagtacact 462301 tgttcagctc atgaagttgt ttgaaaacaa gtggggcagc tttttgcttt ttgcgaacac 462361 tgactttacg caatacagaa gcggagagac agcgttgttt tcaggcatga cgccattgtt 462421 ttcaattgga attctcatca tacatgccat attcttcatc gttgttggct ggtggtgctt 462481 ctgtaaacgg gatgttcggg tctaaaggca aggaatgaca tttttgtgaa aaagctcacg 462541 taaatcaata tcatttgata ttttggttta tactaaaggt actgacggag gtgtctcgat 462601 tgaggaactt tattaccgct ttaccgatcg tattgctgct tggattctca tttgtgtcat 462661 tcatgtttca gtttgaacat cttgtttatt tcaggctcgc gcttgggttg ttttctctcg 462721 tgggactgta catgatatat aaaatgaaga cgggcatccg ctattttatc atctatctgt 462781 atgccagctg gattgtgttg gccgcagtga ccgcttttga agagccgatt ttctcaagct 462841 ttttctttgg cggcctggtg atgacgatgg gttacctgac atatatgctg atttatctcg 462901 gcatgaaaca agaccgggat gcaaatcctg tgtaatcgcg ctgttccctt ggggaacggc 462961 gtgtttttct atactgggca aaaggttaac agttgcggaa aaatggcagg aaatctataa 463021 tacatattaa atttatcgga attaaaactg gggggctgcc ggatgtcatt atttatacaa 463081 aacgatcaac agcggcaatg gatggagaaa atcggacgga ttgcggatga atttcagcaa 463141 acagctgctg aagatgacga acagggacgt tttcctgcag agaaaataca aaaactgcgt 463201 gatgctgggt atacagcatt aacattgccg gcatctcatg gcggaggggg catttctgtt 463261 tacgatatgc tcttgtttca agaacggctt gcacggggag atgctccgac ggctcttagc 463321 atcggctggc atttgagcgt gatcggggag cttggagaag gcaacagctg ggatgaagac 463381 gtatttgcat ttgttgccaa ggaagtccaa aacggagccg tcattaacag ggcggcgact 463441 gaagcgaaaa ccggaagccc gacaagagga gggcgtcccg gtacacacgc cgtcaaaaag 463501 gatggcaaat gggcagtgaa cgggagaaaa acctttacga cgatgtcaca agctctggat 463561 tattttttag taaccgcatg gattgaggac aaacaaacaa caggcgtgtt tctcattcat 463621 aaagatgatc ccggcttgtc gattgaagaa acgtgggata tgatggcgat gcgggcgact 463681 gggagccatg accttgtact gaacgaagta atgcttgatg agaataagct ggtggaactg 463741 cttcaagggc ctcgtggagc taagccgaat ggctggctgc ttcacattcc tgcgatttat 463801 cttggtgtgg ctcaagctgc tcgtgactat gcagtgcaat ttgcatctga gtattctcca 463861 aacagcttga atggaccgat caagaatgtc ccggccgtac agcaaagaac aggcgaaatg 463921 gagcttgaac tgctcaatgc cagacacttt cttttccata tcgctcaatt gtatgacgat 463981 ccggtgcggc gtccacactt gaccagcgag ctcggtgcgg cgaaacatat cgtcacaaac 464041 gctgcgctgt ctgttgttga taaagcgatg agaattgtcg gggccaaaag cctggaacga 464101 accaacccgc ttcagcgcta ttaccgtgat gtgcgcgccg gtcttcacaa cccgccgatg 464161 gatgacgccg tgatacacaa gctggcagct gaagcgtttg agtcataaaa aaaagagcct 464221 taccggctct ttttatgtat tgttttgctc ttgcagattt ttttgatgct tgcggtcgat 464281 cctgtcataa ataacgttca tcagctttgg attgcccata atcgcctctt tgttttcctg 464341 gatcagctgt tggtaagttt tcactttacg cttcggcatg ctccggcgcc ctcctgacat 464401 gtttgtattc actttctaac tccgtcagcg acaattcata cagatgacgc tttgactttt 464461 tgtatatacc attctgtatt aacagatgaa tgagctgttt ttttctgatt tctgcagact 464521 gaggtgtcat tgtgtcacca acctccaatc aaacgatatt gataatcatt atcaattaac 464581 ttcagtatac aatgtccgca atagcctgta aagatgaaaa gagtcctatt cttggccaat 464641 ttacaaacat tcaacaaatc gacaaaaagt ttcccgggca ataatttgct gtcgaaatat 464701 tccgcttcat tgaacgcacc ctgctatttt tcatgttttg aaccatacta tgtaatagaa 464761 tggaggctgg tattcaatgg agcggacaga aaatctgaaa aagggagaaa aaggggcgct 464821 cctcaatatt tttgcatatg tcatccttgc tgttgtaaag ctagttatcg ggattctata 464881 tcattctgaa gcgctgagag cagacgggtt aaataatgga acagatattg ttgcgtcagt 464941 agcagtgctg ataggattgc ggatttctca aagaccggct gacagcgatc atccatacgg 465001 ccattatcgg gctgaaacaa tttcgtctct tgttgcgtct tttattatga tggcagtcgg 465061 cattgaagtg ttaatcggcg gaggaaaagc gattgcgggc ggcacaacgg aaacgccaaa 465121 tcttatcgcg gcatggacgg cgttaggcag tgctgtgttt atgtatggca tctatttata 465181 taacaaaagg ctggcagcgt ccattaaaag ctctgccctg atggcagcgg caaaggacag 465241 caggtcagac gcttttgtaa gtgccggcgc gtttatcggt gttttttcgt cccagctgaa 465301 gctgccgtgg gttgatccgg taacggcttt tatcatcggc atcatcattt gcaaaactgc 465361 gtgggatatc tttaaagacg cttcacattc cttaacagac ggcttccatt taaaagatct 465421 tgagccttac aaacagaccg tcggcaggat cgaaaatgtg catcgcctaa aggatgtgaa 465481 agcgaggtat ttaggcagta cagttcatat cgagatggtg attacggttg atccgaagct 465541 tacagtagaa gaaggccatg gagtggcgga tgaagtagaa gacaaaataa aacatgaaca 465601 cgatgtcact catgttcatg ttcatgtaga gcctgacgac ataaaataag gctgtttaac 465661 gaattagctt atatgttcag ataaaaattc agtcacttct tcaggcgttt tggcattggc 465721 gctgtgaagg tgagctgttt tttcaccgtt cttgaaaata agcaggctgg gaatgcccat 465781 tacttggtat ttttcagcca ggtcaggaag ctcgtcctta ttcagctcat accagtcgtt 465841 ttggttgtat tcttccaaaa tatcgccgat gaacatattc atgcgtgtgc agtctgggca 465901 ccaatcagca taaaacttta caatgatttc tttatcagat tgaatcagtt cattaaattg 465961 ttcgtttgtt gtgatttttt tcatatgtca catctccttt tcaatgccat tttaatataa 466021 aataaaaagg aattacatac aaatgcattc aacatcagca tgcccaaaaa taattagatc 466081 attttccggt gaaaatgata agatagtaaa gatgaattgt agtgggggga gtatccattg 466141 aaaacaagtc taggattagt gtacggagga aagtcggcag aacataatgt ttccctgcag 466201 acagctctgg ctgtaatcaa agcgctaaat actgagaagt ttgatataca tccgatttat 466261 ataacagaaa aaggcgaatg ggttagaggc gcccgtttaa ctgaacctgt ttcaaacgtg 466321 aaaatgcttc aatttgagca aggaggcagt gctttttctc cagctgccct gaaccaggag 466381 atgtttccgc aggaagcgtc acagcaaaat gaagccatcg acgtcgtatt cccgctcctc 466441 cacggaccga acggagaaga cggtacgatc cagggaatgc tcgagctgtt gaacattcct 466501 tatgtcggca acggagtgct tgcttcctca gctggcatgg ataaagttgt catgaaacat 466561 ttatttgcgc aggttggcct tgctcaggct aaatacgcag ctttccttaa gaaagactgg 466621 actcgttctc cgaaagaaag ctgtgaggag gttgaacagg aattaggcta cccttgcttc 466681 gtaaaaccgg cgaacctcgg ctcaagtgtc ggaatcagca aatgccgaaa ccgtgaagaa 466741 ctgcaaaaag cgtttgagct tgctttccaa tatgaccgca aagtcgtcgt tgaagaagga 466801 attaacggcc gcgagatcga aatcggcgtt cttggaaatg atgatcctaa atgctctgtt 466861 gtgggagaaa tcgcaccgaa gacagatttc tacgattaca aagcgaaata tgaggatgga 466921 gatactgatc tgatgattcc ggcgattgtg actgatgagg aatacgcaac aatcagtgat 466981 atggcgatca aagcgtttaa agcgatcgac ggttcaggac tcgtcagagc ggactttttc 467041 ctgacagctg acggcgaagt tctgatcaat gaagtcaaca caatgcctgg ctttacacct 467101 ttcagcatgt tcccgttgct ctggaaagaa gccggagtgg aatatgctga cctgattgaa 467161 cagcttgtgg agcttgcaaa agaacgccac gctgaaaaac aattgattaa gcatacattc 467221 taatgaagaa ggacactgcc ggtaaaaggg cagtgttttt tcccgtatat acaaaagaaa 467281 gagagggacc ttacttgatt aagcgaacag taaaaaacat tgccgaaatg gttaaaggca 467341 cactagcaaa tccgcaatat gaacaaacag tcattcatgg agtggcaacc gatacaagaa 467401 aactggaaca acatcagctc tttattccgc tgaaagggga acgttttgac ggccactctt 467461 ttgtggagca ggcctttgaa gctggtgtag cggctgttct ttgggatcgg tcagtaccaa 467521 atccgcccga gaatcacgcc gtcattttag tggacgatac ccttactgca cttcagcagc 467581 ttgcaaaagc ttatttgcag gagcttggca cgcgtgtcat cggagtaacc ggaagcaatg 467641 gcaaaacgac aacaaaagat atgattcacg ccgtattggg gacccagtac cgtgtccaca 467701 aaactggagg aaacttcaat aatcatatcg gtttgccgct gacggtttta gcgatgcctg 467761 aaaatacgga gatcgccgta ttggagatgg gaatgagcgc caaaggagaa attgacctct 467821 tgagccgact ggcaaacccg gatgcggcag tgattacgaa tatcggcgaa tcgcatatgc 467881 aagacctcgg ctctagagag ggcatcgcgg aggcgaagct tgaaatcata aacgggctta 467941 aagaagacgg agtgctgatt tatatcgggg acgaaccgct tcttcaaaat gcatacagct 468001 gccagacgaa aacgtacggt acgggaacgc ataatgatta tcagcttcag gatgtcagcc 468061 agagtgagga aggaacccat tttacaatca aagggataga aaacacgttt tttattccaa 468121 tactcggcaa gcacaatgtg atgaacgcca tggctgcaat tgctgcaggg gcttattttg 468181 gcatcgcgcc tgaggatgcg gcaaaaggac tgagcggcct aaaggtaacc gggatgaggc 468241 ttgaactcat caaaacagac agcggccttt cgataatcaa tgacgcttat aatgcgagcc 468301 cgacttccat gaaagctgca attcaattga cagaaagcct tgaaggctac ggcaaaaaaa 468361 tgctcgtgct cggtgatatg cttgaactcg gcgatcttga agaaacgttc cataaagagt 468421 gcggcgctgt gatcagccct gataaaattg accgcgtctt tacgtacgga aaactgggag 468481 cttttatcgc ggaaggcgcc ctgaaacact ttgagaaaga ccgcgtcagc cattacactg 468541 agaaaaaaga tctccttcaa gctgtgaagg aaaacgcatc aaaaggcgat ttgattttat 468601 tcaaagcgtc cagaggtatg aagcttgaag aaatcgttaa agatttaata gagagcccgc 468661 tttcataaga aaatattttg cgaaaaaacg catattgcat cataaaataa cctgatatgc 468721 aaacactaat gtatgccggc cgaaaattat gtatatctgg ccggctgcgg ctatgataca 468781 atatatatag gttatttcgc gatacgaaca tattcgtccg gacttttcat cgtgacccga 468841 agttctccgc tggattcttg ggagcggatg gagcagcagc cggcatattc gagatgccga 468901 tctgcttctc atcttattga aaaacaaata gtgtaatggt aagataaaac ttaaagtaat 468961 tcgggctttg tatacggatg gatcctgtcc ttcttgtcta aagggcagtt ttataagtgg 469021 taaatcacga cattactgaa acagcaatta gaaggagttt gaataatttg actataacgt 469081 ttcaagattt taatttaagt tctgatctca tgaaagcaat taatcgtatg ggatttgaag 469141 aagcaacacc gattcaggca caaacgatac cgctcggact ttcaaataaa gacgtcattg 469201 gacaagcgca aacaggtaca ggtaaaacag ctgcgtttgg tatacccctt gttgaaaaaa 469261 ttaaccccga gtctcctaat attcaagcaa tcgtaatcgc gccaacccgt gaattagcca 469321 ttcaagtatc tgaagaattg tataaaatcg gacaagataa acgtgcgaag gttcttccta 469381 tttacggcgg acaggatatt ggacggcaaa tccgggcgtt aaagaagaat ccgaatatta 469441 ttgtcggaac acctggacgt cttcttgacc acatcaaccg ccgcaccatt cgtttaaaca 469501 atgtaaatac cgttgtaatg gatgaagcgg atgaaatgct gaacatggga ttcattgacg 469561 atattgaatc tatcctttca aacgtgccaa gcgagcatca gacacttctg ttctctgcca 469621 caatgcctgc gccgatcaaa cgcattgcag agcgcttcat gactgagccg gaacacgtaa 469681 aagtaaaagc gaaagaaatg acggtttcta acattcagca gttctatttg gaagtgcaag 469741 aacgtaaaaa attcgataca ctgactcgcc ttcttgatat tcagtctcct gagcttgcga 469801 tcgtattcgg acgtacaaaa cgccgtgtcg atgagctggc tgaagctctg aaccttcgcg 469861 gatatgcagc tgaaggtatt cacggtgact taacgcaggc gaaacgtatg gttgcgcttc 469921 gtaaatttaa agaaggcgca atcgaagttc tagtcgcaac tgatgttgcc gctcgcggac 469981 ttgatatctc aggtgttaca cacgtataca acttcgacgt gcctcaagat cctgaaagct 470041 acgttcaccg tatcggaaga acgggccgtg caggaaaaac aggtatggcg atgacgttca 470101 ttacaccgcg tgagaaaagc atgcttcgcg caattgaaca aacaacaaaa cgcaaaatgg 470161 accgcatgaa ggagcctaca cttgatgaag cgttagaagg tcagcaacag gttactgttg 470221 aacgtcttcg cacaacaatc agtgaaaaca acctgaactt ctacatgaca gcggcagctg 470281 agctgcttga agatcatgat gcagtaacag tggttgcggc ggctatcaaa atggctacaa 470341 aagagccaga cgacacaccg gttcgcttaa cagacgaagc gccgatggtc agcaaacgct 470401 acaagaacca gcgctcttct aaacgcagag acggtcaagg cggcggctac cgcggcggaa 470461 aagggaaaag caacaaccgt tcttcctatg acaaaaagcg ttcaaacgat cgccgttctt 470521 caggtgacag acgccagaaa aaatcttact aatttgatcg attcagagcc caaaacatga 470581 tgttttgggc ttttttatgt tcgtgatttg ttattcagca aactttcagc tgacggaagc 470641 catttttctc tgtatgctta agaatgaaac ctttctgtaa aagagacgta taaataacga 470701 cgaaaaaaag ggaggtaggt atttttgaga gagcagccaa aaaaccaaat cagtccagac 470761 ggattaaagg tttggcgact tcaagagatc atcatatccg ctgtttgctt gcttattgtc 470821 attgcagttg cagtgttaag ctattatttt cattggccgt actggatcag cggcgtgctc 470881 ggcgctgttt ggctgctggg atcgattgtg acggtcttta tcattccgaa ggtccgtcat 470941 aaggtgtggc gatatgaagt ccatgaacat gaaatagata ttcagtcagg tatttttgtg 471001 gtgacacgtg tgattgttcc gatggtcaga gttcagcacg tcgatacgtc acaagggcca 471061 ttattaaaaa aatacaacct ggcaacggtg aaaatttcca cagccgcgac cgttcattcg 471121 atccccgctt tagagatgga ggaagcggat cggctaagag actccatttc ccgtctggcg 471181 agggtgactg acgatgatgt ctgaaccgaa acgcctgcac ccggtggcag tcattttgaa 471241 tttatgccat accattattc aaacgataaa aaatatcatt ctgccattct tttttgtgta 471301 tattgtcaat tcaaaccata ctgtccgttt ttacggagcc attgcgctcg gtgtgctgtt 471361 catctggctt gtagcggcaa gcattatcaa atggagaagg tttacctatc gaattgaaga 471421 tgatgaattt agaattgaag aaggcttatt tgttacgaaa aaacgataca tatcgattga 471481 tcggattcaa acaatgaata cgagcgcggg ccttgtccag caaatcttta agcttgtgaa 471541 gctgcaaatt gaaacagcag gcggaggcaa ggaggcagaa gccgttcttt ctgctatttc 471601 tgttgaagaa gcggaacgca tcaaagaagc tgtctttaag aaaaaagcgc aaagacgaga 471661 aaatgaactt gatgaagaac ggcttgaagc tgaagaggag ttggatccgt ccgttgaggt 471721 gcaagagcac tatcgcatga acgcgaaaga attgctcatg gccgcttcta cctccggcgg 471781 aatcggagtc attatctccg ctgtatttgc acttatttcc cagcttgatg aagtgctgcc 471841 gatggattgg ttattcgata aattttcctt ccttcagcac gccagcatcg gtatttatgc 471901 ggtactcatt tttatcggtt tatttatcgc ctggattttc agcatcgcgg gcatgatgtt 471961 tagatacgcg aactttcaaa tcataaaaaa agagcaggaa ctggtgattt caaggggaat 472021 tattgaaaaa catcaagtca cgattccgct gcgaaaaata caagccatta aaatcaaaga 472081 aaatatcatt cgccagcttt tcggctttgt aacggtgtcc atcgtcagcg caggaggcgg 472141 cgaccgggaa aaagaagaag gcgctttgac cattctcttt ccaatgattc ataaaaaaaa 472201 gcttccgcac atgctccgaa catttacgcc ggaatacacg ctggaagaaa actgccgccg 472261 cctgccgcgg cgcgcgttga aacgctattt gttccgttct gtcatttttt cactcttttt 472321 gatcatcccg ttatgtatct tctttcagcc atggggctat ctgtcagtga tcctgctgcc 472381 gatagaattg ctcttcggct atctcgcgta taaagaggct gcatggacga tcaacgggga 472441 ccgtcttcag ctgacgtcta gatttatagg cagaacaacc gccattgtac tgaaaaaacg 472501 aatgcaggtc tgcaagttca gccaatccta tttccaaaag aaaggccgct tgtataccat 472561 ttctacttcg gtgaaatcat cgagccatat ggaagagtta acggtgaggg acgtaggtga 472621 agaggatgca gccttcattt taaagtggta ctcatatgaa aaagcggacg gttaataccg 472681 ccgctccagc gtgtcggcaa accctcgcat tcgttgtcag gactgcgctt cggtgctcaa 472741 tgcgaagtgg atcaacggct aaattctcag gcgtcctgcc taaacgccgt cgtcatcaca 472801 tcctgtgaaa gtccgctcct atgctcgtcc ttcctagact tcatgggttt tcaatcacgc 472861 tgaaaagatg acaaaatcct aaaatgaaaa ccattttagg attttgtcaa caatctgaag 472921 cggcggttaa taccgccgct cttttttttg cacgcataaa aacgaaagaa gaaacccgcc 472981 gcatagtcca aacaaatggg ccatcatgtt aatattggag ttgataaacg acatgagaac 473041 ggcaaatgcg agcagtgtga tgatcatttt ggaatgctcc tgcccaatta actcattgcg 473101 aaaaagaacc ataaacaggt atacgccaaa tagcccgaaa atggcgcctg aagccccgac 473161 atgcacgtaa tcaagcggct ctgtaacata agtgccgata ttgccgatga tgccggagcc 473221 ggcgtataca agaaggaaac gcgcttttcc cagcatgcgt tccaaagccg gggcaaataa 473281 aaagatggac atggaattaa acagcagatg tgtgaaaccg gcgtgcagca aaatcggtgt 473341 gataagccgc caccattcac cgtttgcgac acctagatta tagcctgtga cggtatccct 473401 ccataacacg actgaatggg caggaagtga aaaaaacagc cagagaacag cttgcaaagc 473461 caatataaag gtgacaacgg ggtaaagcct gataaatgtt tgaaaatttt cagtccgtat 473521 aaacattccg agcccctttt cttcattttg gtatatctat agtaacacgt ttatgagaca 473581 aaccatttaa atagtacgta cgcaaaggag gttatcatac atgatttacg gcattgggct 473641 ggacattacc gagcttaaac ggatcgcctc tatggctggg cgccagaaaa ggtttgccga 473701 gcggattttg acgcgaagcg agcttgacca atactatgag ctttcagaga aaagaaaaaa 473761 cgaatttctc gcgggcagat tcgcggcaaa agaagcgttc tcgaaagcat ttggcaccgg 473821 cattgggagg cagctcagct ttcaggacat tgaaattagg aaagaccaaa atggcaagcc 473881 ctatatcatt tgtacgaaac tgagccaggc cgccgttcac gtatcgatca ctcatacaaa 473941 agaatacgct gccgcgcagg ttgtgattga aaggttgtca agctagtctg catattaggg 474001 aaaccccact catatatttg atagtgcatt aagggagaca agttgtttga ggcttttatg 474061 gtacgcatct gttctgccta aacgtgtacc gagcgtaccg ttaaagtcaa acaagcgatt 474121 tcttcctttt acatcaattg agaaaaaggg gttgaaaaag gtgagaaaaa gctttgtttt 474181 gcttttaacg ggactgcttg ctgttcttat tctttctgcc tgcgggcaaa aaacacagca 474241 agatattgtg gccgggttag atgaaaaggc gaaagaatac acctcgtaca aagcaaaagc 474301 gaaaatgacc atcgagacag ggagtgagcc tcaagtatac aatgtggaaa tctggcacaa 474361 aaagccgtct ctgtacaggg tttatttaga aaatccgaaa aaggaccaaa accaagtcat 474421 tttacgaaat gaaaacggag tattcgttct cacgccgtct ttaaataaga gcttcagatt 474481 tcaaagcgat tggccgaaca acagcagcca ggtttatctg tttgaatcgc tcgtaaagga 474541 tgttcaaaac gattcggatg cagttttcac agcgaaagaa aagaaatacg tatttgaaac 474601 aaaaacaaac tatcagcata acaaaatgct gcccacgcaa gaaatcacat ttaacaaaaa 474661 agatatgagc ccgtcatctg tcaaagtgat ggatactgac cggaaagtga tggtcaaagt 474721 agaattcagc agctttgaat ttaataaaca atttgataaa gaatcatttg atgaaaagaa 474781 aaatatgacc ctttctcaaa tggatgtcgc cacaagcgca aagccttccg atacatttgc 474841 ggtcaaaacg ccgctggaac tgccgcttgg cgtcaagctg cttgaagaaa aagatatatc 474901 tactgaagac gggaagcgca tcatcatgac gtacggagga gaaaaatcat ttacgttaat 474961 tcaggaaaaa gcccagattg ccaaggcttc ctcctccgtt acgctgaacg gcgaaccggt 475021 aaatctcggc tacaccatcg gcgccctgtc ggatgcatca ttatcatgga catatgacgg 475081 cgtagattac cttctctctt ctaaagatct ttctaaagag gaaatggtga cagtagcgaa 475141 aagcatgcag ggacaatcat cgaaataacc gccaaaggcc aaacatgatt tggccttttt 475201 ttcgttagac atcgtttccc tttagccttt aattttagta tgatatgtaa atgatattga 475261 ataaaagcta ggaagtgtcg taatgagcac aaaacctttt tacagagata cgtgggcgga 475321 aattgacttg tccgcgataa aggaaaatgt cagcaatatg aaaaaacata tcggtgaaca 475381 tgtccacttg atggcagttg tgaaagcaaa cgcctacggg catggtgatg cagaaacagc 475441 aaaggctgct cttgacgcag gtgcttcatg cttggccgtg gccattttgg atgaagcgat 475501 ttcactgcgc aaaaagggat tgaaggcgcc tatattggtg cttggcgcgg ttcccccgga 475561 gtatgtggca atcgctgctg agtatgacgt gaccttaaca ggttattctg ttgaatggct 475621 tcaggaggca gcccgccaca cgaaaaaagg ttctcttcat tttcatctga aggtcgatac 475681 ggggatgaac agacttggtg taaaaacaga ggaagaagtt cagaacgtga tggcaattct 475741 tgaccgcaac cctcgtttaa agtgcaaagg ggtatttacc cattttgcga cagcggatga 475801 aaaagaaaga ggctatttct taatgcagtt tgagcgcttt aaagagctga ttgctccgct 475861 gccgttaaag aatctaatgg tccactgcgc gaacagcgcc gctggactcc ggctgaaaaa 475921 aggctttttt aatgcagtca gattcggcat cggcatgtat ggccttcgcc cgtctgctga 475981 catgtcggac gagataccgt ttcagctgcg tccggcattt accctgcatt cgacactgtc 476041 acatgtcaaa ctgatcagaa aaggcgagag cgtcagctac ggagccgagt acacagcgga 476101 aaaagacaca tggatcggga cggtgcctgt aggctatgcg gacggctggc tccgaaaatt 476161 gaaagggacc gacatccttg tgaagggaaa acgcctgaaa attgccggcc gaatttgcat 476221 ggaccaattt atggtggagc tggatcagga atatccgccg ggcacaaaag tcacattaat 476281 aggccggcag ggggatgaat atatttccat ggatgagatt gcaggaaggc tcgaaaccat 476341 taactatgag gtggcctgta caataagttc ccgtgttccc cgtatgtttt tggaaaatgg 476401 gagtataatg gaagtaagaa atcctttatt gcaggtaaat ataagcaatt aacttaccta 476461 aatggagaat tcataaaaca gctttgcttg aagagtgaat aatggtatca ttatcactgg 476521 atggataaaa gagtcgtatc cgtaagtttg gtggaggtgt atgttttttg tctgaatcca 476581 gcgcaagaac cgaaatgaaa atcagcttgc ccgaaaacct agtagctgaa ttggatggtg 476641 tagcgatgcg ggagaaacga agcagaaacg aactgatatc acaagcagtg agagcgtatg 476701 tcagcgaacg aacaactcgt cacaaccgtg atttgatgag acgcggctat atggaaatgg 476761 cgaaaatcaa cctgaatatt tcttctgagg ctcactttgc ggagtgcgag gctgaaacga 476821 cagttgagcg cttagtcagc ggaggataat catttgattg tgaaacgcgg cgatgtttat 476881 tttgctgatt tatctcctgt tgttggctca gagcaaggcg gggtgcgccc ggttttagtg 476941 atccaaaatg acatcggaaa tcgcttcagc ccaactgcta ttgttgcagc cataacagca 477001 caaatacaga aagcgaaatt accaacccac gtcgaaatcg atgcaaaacg ctacggtttt 477061 gaaagagatt ccgttatttt gctggagcaa attcggacga ttgacaagca aaggttaacg 477121 gataagatta ctcatctgga tgatgaaatg atggataagg ttgatgaagc cttacaaatc 477181 agtttggcac tcattgattt ttagacatat ttgcaggttg ctcaaataga gcaacttttt 477241 ttgttttcaa aaaacataaa cgatataata gtgaaataac gaaaaaatat gttgtttttt 477301 attgggaggt aagcgaattt gatgtcgaac cagactgtat accagttcat tgccgaaaat 477361 caaaatgaac tgctccaact gtggactgac acactaaaag aattaagcga gcaagaatcc 477421 tatcagctga ctgaccaagt gtatgaaaat atatctaaag aatatatcga cattctgctg 477481 ctgtctgtta aggacgaaaa tgctgctgaa agccaaatca gcgaactggc gcttcgagcg 477541 gtccaaatcg gactgtctat gaagtttttg gctactgcac ttgccgaatt ctggaagcgt 477601 ctctacacga aaatgaatga taagagattg ccagatcaag agagcacgga attaatctgg 477661 cagattgatc gctttttcag cccgattaac acagaaattt ttaatcaata ctcaatctca 477721 tgggaaaaaa cagtatccct gcaaaaaatc gcgctgcaag agctgtctgc gccgcttatc 477781 ccggtgtttg aaaatatcac tgtgatgcct cttgtcggaa caattgatac cgaacgcgcg 477841 aaacgaatta tggaaaacct tcttaatggc gtcgtcaaac accgttccca agtcgtgctg 477901 attgacatta caggtgtccc tgtcgtcgat acgatggttg cccatcatat tattcaggca 477961 tcagaagctg taaggcttgt cggagcaaaa tgcctgctgg ccggaatccg tccggaaatt 478021 gctcaaacaa tcgtcaacct ggggattgat ttatcccaag ttataactaa gaataccctg 478081 caaaaaggaa ttcaaacagc attggaaatg acggatcgaa aaatcgtttc attgggggaa 478141 taacattttg agacatccga aaatcccgat cttgaaactg tataattgct tattagtgtc 478201 cattcagtgg gaacttgatg accagacagc attaactttt caagaagact tattaaataa 478261 aatatacgaa acaggtgcta acggagtcgt cattgacctg acatctgtgg atatgattga 478321 ttcatttatc gcgaaagtgc tgggggacgt cattacaatg tctaagttaa tgggggctaa 478381 agtcgtcttg accggcattc agcccgctgt ggcagtgacg ctgattgaac ttggaatcgc 478441 gcttgaggaa atcgaaactg cgctcgactt agagcagggg cttgagacat tgaagcggga 478501 attgggggaa tagcgaatga acgaccaatc ctgtgtaaga atcatgacag aatgggatat 478561 tgtggccgcc agacagctgg gacgaaacgt tgcgaaagaa ctgggtttcg gcacggtaga 478621 ccaggctaga attacaacgg ctatttcaga attagccagg aatatttatt tatatgccgg 478681 caaagggcag attggaattg aacaggtcgc agacagagga aaaaaaggcc tgaaaatcat 478741 agcggaagac caagggccgg gaattcctga tatccgaaaa gtcatggaag acgggttttc 478801 aacgtctgga ggacttggtg cgggacttcc cggggtcaaa aggctgatgg atgaattcag 478861 cttaaattcc gtagcggggg aaggaacaga gatacaagcc atcaaatggc ttcggtagga 478921 ggtaagaacg tggattttag ggaggttatt gagcagcggt atcatcagct gcttagtcga 478981 tatatagccg aattaacaga aacatcttta tatcaagccc aaaaattcag ccgaaaaaca 479041 atcgagcacc aaattcctcc ggaagaaatc atcagcattc acagaaaagt gctgaaggag 479101 ctgtatccaa gtctcccgga agatgtgttt cattcgctgg attttttaat agaagtcatg 479161 attggctatg gaatggctta tcaggagcat caaaccctta gagggataca gcaggaaatc 479221 aaatcagaaa ttgaaatcgc ggcaaatgtc cagcagacgc ttctcggaac taaagttcct 479281 caggaggaag cgctggatat cggcgccatc agtgttcccg ctaaacagat gagcggtgat 479341 tactaccact ttgtcaaaga caaggaatcc atcaatatcg caatcgcgga cgtgatcgga 479401 aaaggcattc cagcggcttt atgcatgtcc atgattaaat acgcaatgga ctctttgccg 479461 gaaacgggca tacacccttc tcaagtgctg aaaaatttga atcgtgttgt tgaacaaaac 479521 gttgatgcca gtatgtttat tacgatgttt tatgcgaatt acaatatgga caagcatcaa 479581 tttacatatg cttcagcggg acatgaaccg ggattctatt attctcaaaa agacaacacg 479641 ttttacgatt tagaggccaa aggactcgtt ctcggcatct cgcaggacta tgactacaaa 479701 caattcgatc agcatctgga aaagggcgat atgattgttt tattttctga cggcgtcaca 479761 gaatgcagaa cggaaaacgg tttcttggag cgtcctgatc tgcagaagct cattgaggaa 479821 catatgtgtt cctctgcgca ggaaatggtc aaaaacattt atgacagcct cctcaaattg 479881 caggattttc agcttcacga tgattttacg ttaattgttt tgcggagaaa ggtttaacgt 479941 ctgtcagacg agggtataaa gcaactagtg atttgaagga aaatttgagg tgatacgaat 480001 gaatataaat gttgatgtga agcaaaacga gaatgatata caagtaaaca ttgcaggaga 480061 aattgatgta tactcagccc cggtgcttag agagaagctc gttcctctgg cagaacaagg 480121 agctgactta agaatttgcc tgaaagatgt cagctacatg gacagtaccg gattgggcgt 480181 ttttgtaggg acctttaaaa tggtgaaaaa acaaggtggt tcgctgaaac ttgaaaatct 480241 ttctgaacgg ctgatccgac tgtttgacat tacaggcttg aaggacatca ttgatatttc 480301 tgcaaagtca gaaggtggag tgcaatgaag aataatgctg attacatcga aatgaaagtg 480361 ccggcccaac ctgaatatgt gggaattata agactgacgc tgtcaggggt cgcaagcaga 480421 atgggctata cgtacgatga aattgaagac ttgaaaatcg cagtcagtga ggcgtgcaca 480481 aatgcggttc agcacgctta caaagaagat aaaaatgggg aagtgtcaat acgattcggt 480541 gtgtttgaag accgtttaga ggttattgtg gcggatgaag gagacagctt tgactttgat 480601 caaaagcagc aggatctagg gccgtacaca ccttcgcaca cagttgatca attatcagaa 480661 ggagggctcg gtctatattt aatggaaacg ctcatggatg aagtcagagt gcaaaaccac 480721 tccggcgtca ccgtagcgat gacaaagtat ttaaatgggg agcgagttga tcatgacaca 480781 accatcaaaa actacgaaac taactaaaga tgaagtcgat cggctcataa gcgattacca 480841 aacaaagcaa gatgaacaag cgcaggaaac gcttgtgcgg gtgtatacaa atctggttga 480901 catgcttgcg aaaaaatact caaaaggcaa aagcttccac gaggatctcc gccaggtcgg 480961 catgatcggg ctgctaggcg cgattaagcg atacgatcct gttgtcggca aatcgtttga 481021 agcttttgca atcccgacaa tcatcggtga aattaaacgt ttcctcagag ataaaacatg 481081 gagcgttcat gtgccgagac gaattaaaga actcggtcca agaatcaaaa tggcggttga 481141 tcagctgacc actgaaacac aaagatcgcc gaaagtcgaa gagattgccg aattcctcga 481201 tgtttctgaa gaagaggttc ttgaaacgat ggaaatgggc aaaagctatc aagccttatc 481261 cgttgaccac agcattgaag cggattcgga cggaagcact gtcacgattc ttgatatcgt 481321 cggatcacag gaggacggat atgagcgggt caaccagcaa ttgatgctgc aaagcgtgct 481381 tcatgtcctt tcagaccgtg agaaacaaat catagacctt acgtatattc aaaacaaaag 481441 ccaaaaagaa actggggaca ttctcggtat atctcaaatg cacgtctcgc gcttgcaacg 481501 caaagctgtg aagaagctca gagaggcctt gattgaagat ccctcgatgg agttaatgta 481561 atgatccagg ttgaagaaaa cgagcatatt caaactctag tatatcaact gaataaagaa 481621 gggaaatcga tttgcggtga cagttttttt atgaaagctg atgataagga gttaatttgc 481681 gcggttgctg acggactggg aagtggatca cttgctaacg aatcctctgc agccatcaaa 481741 gacttagtgg aaaactatgc gagtgaagac gtagaaagca ttatcgaacg ctgtaatcag 481801 gcgatgaaaa acaaaagagg cgctacagca tctatcctga aaatcaattt tgagcaaagg 481861 cagtttacgt actgctctgt cggaaatgta cggtttattc tgcattcccc gtctggtgaa 481921 agcttttatc ctctgccgat ttcgggctat ttatcaggca agccgcaaaa atacaaaacg 481981 cacaccgcca cctatgaaaa gggttcaaag ttcattatac atacagatgg actcaacgta 482041 cctgatatcc gctcccattt gaaaaaaggc caatcggtag aagaaatatc gaattcgctg 482101 aaaatgtata cgacatcgag aaaagatgac ctgacctata ttctcggaca gctgtcctaa 482161 aaaaccagaa aaagaagctg gacatccggc ttcttttttt tgcggttgac tattaataag 482221 tgcgcttatt atacttaata agtgaactta tcattctggg agcttatggg atgtggaatt 482281 atgaatacac agcgatagct gatgtggatg tgggaaaacc tggaactgtt atcaggaaac 482341 agaaacaatg gatcaatggg agacgggtat tgcatcagat tctttgaaag gacaatttca 482401 aaatggaacg gaaggaacat tgcttctgca aggaaaaaca attctcttat ggcttgagca 482461 tgtggagaaa catcgggcgt tttctgtcat ggtcaacatg cccgcatagc aatgtaataa 482521 tggagttttt tcacgtgctt caaaagcaaa aagaagattt gtgtatcaca tatggaattg 482581 tattagaagg cgctgaagca aaaaagtggg gagaaatcat tgggactgaa ctgtctaaag 482641 acatgccgac ggctgtcagc aggcttgtcc atctttacgg aggagtgata aaatgaacac 482701 aaattactgg atcggcgttg tgtcagagca acatgtatta aaaggcgctg ccggcggttt 482761 tgcacagctg tgccatggaa aaaaagcccc gctcgccaaa atgaaagagg gagattggct 482821 gatttattat tctccgagag acgcatatcc agacggcaaa ctgctgcgaa gctttactgc 482881 gatcggcaaa gtaaaaagcg gaaacatcta tccgtatcaa atggctccga attttattcc 482941 ataccgatta gatatagact attatccatg ccataaaatc ggtttttacg acattaaatc 483001 aaagcttgaa tttgttcagg aaaccaagca tcttggcttt ttatttcgca gaggacactt 483061 tgaaataagc aaaaaagatt ttttgacaat agcacaagcg atgggagtta acataagtgg 483121 aatggcactc taaatttagc ggtccgaaca caagcccggg ctttttatta tggcaggcca 483181 cgcaaagttg gcagcggaaa gtaggaaaag cattggctga gtttgacctg acccacgttc 483241 aatttgttct gctgacctcg tgcaagtata tgattgctca cggagaaacc gtcacgcaaa 483301 aaaaacttgc aagcttcagc cagaccaata tcatgatggt ttcggaggtt gtgcggacgc 483361 ttgagaaaaa aggatttatc gaaagaagca aaaatcccca ggataaaaga gaggtcctcc 483421 tgtctcttac agaaatagga ggagaaaaag taacagcggc tttgccaatt gttgagaaga 483481 ttgatcaagc cttctttgca gctgcgatga aaaaagagaa ttttctgagc ggcttacagg 483541 aactattgaa acatgagtaa agatacgggc agcgccagct gtcttttttt atgtgttttt 483601 ttcggttttt gatacactag agaaagaacg acaaaattgg aggctttggt tacatggaaa 483661 cgtcagccct tttaaaacag caaattgcga aagaaatagg tttatcacaa aaacacgttg 483721 aaagtgtcat ccgcctgctt gaggacggca atacagtccc gtttattgcc cggtatcgaa 483781 aagagcagac gggttcaatg gatgaggttc agattcagac gatttctgaa cgctggcaat 483841 acatacaaaa cctgaatcag cgaaaagaag aagtcatcag gctgattgca gagcaggata 483901 aactgacaga taatctaaaa cgtaaaatcg agcaatcggt gaagcttcag gaagtggaag 483961 acctttaccg cccttataaa caaaaacgta aaacaaaggc gacagtcgcc aaaagcaaag 484021 gccttgagcc gcttgccgac tatatcctga cacttcccca agatgatcat ctggcagcaa 484081 ctgcagacca atacatcagc gaagaaaaag aagtgttcac acgagaagaa gcgattgaag 484141 gcgccaagca cattattgcg gaacaaatct cagacgagcc gaccttcaga aagtggattc 484201 gccaggaaac cttcaaaaga ggaaccatta agtctgcagc cggaaagtcg gcagacaccg 484261 atgagaaaaa tgtgtatgaa atgtattacg agtatgaaga gccaattgca aaagttgttc 484321 cgcatagggt gctggcaatg aaccgcggcg aaaaagaaga cattttaaag gtagcgatcg 484381 aaccgcctgc ggatcacatt aaggcgtatt tagaaaaaca aatcatcaaa aatcgctcaa 484441 catccgtaag agagattttg caggagacaa ttgaagacag ctataaaagg ctgatccagc 484501 cggcaatcga gcgtgaaatc aggaaagagc tctcagaaaa agctgatgaa caggcgattc 484561 atattttctc agagaacttg agaaagcttc ttttgcagcc gccgatgaaa ggcaaaaccg 484621 ttctcggtgt tgacccagcc tttcgaactg gctgtaagct cgctgtgtca gatgagaccg 484681 gaaaagtctt gaaaattgat gtgatctatc cgcatgcgcc agtcaacaaa acaaaagaag 484741 cccatgaaaa agtgaaaaag attcttgagc agtatcaagt cgagatggtg gcgatcggaa 484801 acggcacagc atccagagaa acagagcaat tcatcgtcaa tgtactcaga gacatgccgc 484861 gcaaaattta ttatgtgatc gtcaatgaag cgggagcaag cgtctattcg gcttcagagc 484921 ttgccagaga agaattccct gaccttaagg ttgaagagcg cagtgccgta tctattgctc 484981 ggagacttca agacccgctc gcggagctcg ttaagatcga tccgaagtct gttggtgtcg 485041 gacagtatca gcatgacgtc agccaaaaac gcttaaatga atctctgcgg tttgtcgtcg 485101 aaactgtcgt aaaccaggtt ggagtaaacg tcaacacagc ctccgccgcg ctgcttcaat 485161 atgtagctgg attatcgaag tctgtagcag gcaacgttgt caaaaaacgt gaggaaatcg 485221 gaaagttttc aaatcgaaaa gaactgaagg acatcccaag gttaggtgcg aaaacctatg 485281 agcaatgtat cggtttctta agagtgcagg aagggacaga gcctttggat agaacaggca 485341 tccacccgga aagctataaa gaaacaaaag cacttttgaa aaaactcgga ctttcaacag 485401 aacatatcgg cacggcggaa ttgaaggaca aaatcaatca gctggcgctc tctgaaacgg 485461 caaaagagct gggaatcggc gaaatcactc tgaaagacat ttgtgaacag ctgacaaggc 485521 cggaacgcga tccacgcgat aaggtgccta agcctttgct gaaaacagac gtccttcagc 485581 tggaagattt gaaagaggga atggaactgc agggcaccgt gcgcaatgta gtggacttcg 485641 gagcgtttgt tgatatcgga gtcaaacaag acgggcttgt gcatatctca aaattgagca 485701 atcaattcgt caagcatcct cttgatgtcg tatctgtcgg cgatattgtg acagtttggg 485761 ttgacggcgt agatgtacaa aaaggcagag tatcgctgtc tatggtaaaa taaaagcact 485821 gcttacgagc agtgtttttt cctatagaaa taccagcatt gattcagcag tttaatttgg 485881 taattatctt tttcaaggaa cgctttttgc atctgctttt taagccaatt tggcataggc 485941 tcattcctcc tcagctttta tcataagagg gacagtgatt accatattgt atgcgaacgg 486001 tgaattgtcc cgttcaatgt tttttaagtg aggtgcacca tggataacaa agagcttcaa 486061 aagctgacag aggatatttc tgaaacatat tttaaaaagc cgttccgcca tcaggcgctt 486121 tttaatgacc ggcttaaaac cactggcggc aggtacctgt taacctccca taacattgaa 486181 ttgaacagaa aatatttgat tgaacacggc agggaggaac tgattggcat catcaagcac 486241 gagctctgcc attatcatct tcatcttgaa ggaaaagggt acaagcacag agacagagat 486301 tttagaatgc tattgcagca ggtcaacgcg ccgaggttct gtacacccct taagaaaaaa 486361 gcggaaaaca aaaaaactta tatgtatatc tgtacgacct gcggccaaca gtatataaag 486421 aagcgcgcca tgaaccctga cagatacaga tgcggaaaat gccgcggaaa aataaaaaga 486481 attttttcgt gaaaaaggtt gacgaatatg gcaagcctat gttacattat aaaagtcgtc 486541 acgagagata aataaaaaca tttacctctt gacactgcaa atcaaggctg atataataag 486601 tcttgtctca ttattccaca gtagctcagt ggtagagcta tcggctgtta accgatcggt 486661 cgcaggttcg aatcctgcct gtggagccat attggagaag tactcaagtg gctgaagagg 486721 cgcccctgct aagggtgtag gtcgcgtaag cggcgcgagg gttcaaatcc ctccttctcc 486781 gccataagat ttcgatataa gttctcaacc atcggcccgt tggtcaagcg gttaagacac 486841 cgccctttca cggcggtaac acgggttcga atcccgtacg ggtcattcca tttcgttggg 486901 ctatagccaa gcggtaaggc aacggacttt gactccgtca tgcgttggtt cgaatccagc 486961 tagcccagcc atttttattt ttgaaatcta atagtaagag ccattagctc agttggtaga 487021 gcatctgact tttaatcaga gggtcgaagg ttcgagtcct tcatggctca ccatttgtct 487081 ttttgcgggt gtggcggaat tggcagacgc gctagactta ggatctagtg tcttacgacg 487141 tgggggttcg agtcccttca cccgcacttt atttacaaag tgcacgcaaa tctgttttac 487201 taggttaaga gcctactaaa ccagcacaac acaatttaat gatcacgcgg tcgtggcgga 487261 atggcagacg cgctaggttg agggcctagt gggtgaataa cccgtggagg ttcaagtcct 487321 ctcggccgca tctcaataat accaagggtt taaccacctt tggtattatt tttttgtgtg 487381 gaaaatacgg ctatgggaga agacttgctc accaaaactc accagttact taaagtaagt 487441 catccaaacg gtcggcggtt ccttctgttt attaggaaaa agatatccgt tcattgtaaa 487501 agaaacgaac catgtcctat tcgttcaaaa aaactaaagg gtgatacata ttatacatga 487561 ttaatatgta tcaccctttt ctttcttgtt caacaatcgc gcttgaggag aacataagct 487621 aatacaactg actcgatttc taaagttgct ccattctttt tttaaacaac tcatccacaa 487681 cctgttttaa aatctcgtac gactgaattt ccttgctcaa ttcgtaaata ttagataaca 487741 caattaattc atctgcgtga tacatttgtt ggaaatcaat tagttcgcga cgaattgttt 487801 ctcgatcacc catgattgta taccccagtc gactgtggag aatttctaat tcaaactgtg 487861 ataacgattc taggaagttt tcagtgggtg gaataagctt acttaaatta tttgtataaa 487921 tatcaatata cacctgcaaa tgacttgcag aaataaaaga tgcctcgtct atagattctg 487981 ctgcaatcac attaatgcaa gcgatcacat aaggttcttg taaataagaa gacggttgga 488041 aattttctcg ataaatagag agcgcttctt ccatcgaatg gggtgaaaat tgagcgccaa 488101 atgcataggg taaaccaagc tttgcagcaa tttccgctga atccgttgag gatcctaaca 488161 caaaaacagg cacatgcgtt ccaatacccg gataagcgcg aacctcaccc tgtacactct 488221 tatccccgac aaaacgcaaa atatcattta cttctctttc aaagaaaaac actccattat 488281 ggttggaacg acgaatcaca tcggccgttt tttgatccgt tccgggtgcg cgtcctaatg 488341 ccaaatctac acgatttgga tataatgttt caagtgttcc aaattgctcc gctacgatta 488401 atggggaatg atttggcaac ataatacccc ctgaacctac gcgaatgtct tttgtatttg 488461 ctaatatatg ttgtacaatt gatacggttg ctgcacttgc ataagcgtcg tgattatgat 488521 gctctgcaaa ccaaatccgt ttatagccca tattatctac agctttagct aatgacactg 488581 cagaatcaat cccttgtttc attgtttctc cttgtcttaa tggagcaact gataaaacag 488641 atatatcaaa ttttttcata atttcacctc taaaataatg aacttataca agatcaatgg 488701 aaaaaacatt ttgaaaaatt gtttcatatt aaatggtgtc cattcctctt tgatttgcat 488761 gcaaataaat atatactttc tcaaacgatc aatacatagg caaaataaag ttatttcaca 488821 atttcacttt acttttaaag ttttaagcaa acataaaaaa atgttcagtg aacaaaatat 488881 gtaaaataca tcttattttt cagaaaggat acaagaaaat gattgatgaa atagataaaa 488941 aaatacttga tgagctgtct aaaaatagtc gccttacaat gaaaaaatta ggggaaaaag 489001 tacatctcac tgcaccagca accgcatcaa gagtagtaaa gttaatagac aatggcataa 489061 taaaaggatg tagtatcgaa gtgaatcaag tgaaattagg cttctctata catgcttttc 489121 ttaatattta tatcgaaaaa atccatcatc aaccctattt agcttttata gaaacacaag 489181 ataactatgt aataaacaat tataaagtta gtggagacgg ttgctatttg cttgaatgta 489241 aatttccttc aaacgaggta ttagatcaat ttttaaatga cttaaataaa catgcaaact 489301 ataaagtgtc gattgttatt ggtaaatagt taactttata aaacggagat gtgcggtcat 489361 ataacatgat atatatgctc taaaaaagcc ctaggttgga tatggaattt accaagctgg 489421 ggccttttta tacattataa taacaagcgc attattcatc agacattaat gaagtattat 489481 aatgcttttt tacttcctta atagacaaat aaagctgata gtttccatac ttcaataaat 489541 cattcagaag gtgatttaaa acttcttgtg aatgaaccgt taccttcaga agataacatg 489601 catctcccga aacacgatga gcttcgctaa tttcattacg agtagcaata aatttcaata 489661 aatcatcatg catatatgca ttcatgaaaa agaagacaaa ggctgtaaaa gaaaacccca 489721 tcttcaattc atcaaccaca atcgaatatg ctttaatgat accgttatcc tccatttttt 489781 tgatgcgatt gcctaccgct tgtcctgtca tatgaatttt ttcaccgatt tctttccatt 489841 gtatccgagc atttttattt aataattgga gaatttgaaa atcaattgaa tcaatttgca 489901 tagtaactcc tttcacagtg aaaaagtttt acaaaatagt atttcatgag accatcgaaa 489961 attcaatgga aattatatat ccttatacag tataaaaatt ttaagaggtg aaaaaatgac 490021 aacagcttta ttagtgattg atattcaaaa tgattacttt ccaaatggga agatggcttt 490081 aacaaaccca gagaaagcag cacaaaatgc ggctaaacta ctttcacact ttagaaacac 490141 aggcgcacct gtctttcatg tacagcatat cacagaaggt aacatcgctc attttttcca 490201 tccaaataca gaaggtgtcg aaattcatga gtcagtacgt ccattagaga aagagacagt 490261 cattgtaaaa catatgccga atagcttttt caatacagat ttaaatggaa agctacaaga 490321 agaaggggtt aaagaattag ttgtttgcgg tatgatgtcc catatgtgta ttgatgcaac 490381 agttcgttct gcagttgaac atggttatgt atgccaagtg gtagaagatg cttgcgcaac 490441 aacaacattg caaattgaag ataaaatcgt tcctgctgag catgtccatt acgcatttat 490501 ggccgcatta aatggtgtct atgcaacagt aaaaaccaca gaggcatttt taaaataaaa 490561 gaatttcctg cgcgaacata acgtctttct tttcacaaga aagatgattc aacaacttaa 490621 aaaaggatgt tcagaaaaat acttctggac atcctttatt cattatcttt tattgttttt 490681 cagtatcatt attcccatct gataaaagat caagatgtcc tgtttttgat ccatagtaag 490741 accatataca gggattgttt ttgccataaa tatagatatt gatgaaggtt tacataaagc 490801 acctaattgc ttgatttact ttaatgttag atccctcaat aactccattc tcttctaatt 490861 tctctactct agctgtagct gctgggcatg ttaaatgtac tctctcccag atctttcatt 490921 gaattcggct attatacata atttctctat aattttttat ctgtttgatc tatttgaacg 490981 ttaattcctt tcgaaaataa agtcaaagag ttaaaacact tttttttatc tatgtattcg 491041 aacactgctg atattataca cttaactctg tcgatctaag acaaataaaa aaagaaagtg 491101 agttgtaaat atgaatatta cacaaattcg aaatgcaaca attgttgtaa aatacgcaaa 491161 taaaaaattt ttgatagatc ctatgttagc agagaaaggt acgtacgcta ctttccctga 491221 aacgatcaga caagatttat ttaatccttt ggtgagtttg ccaacatcaa ttgataacat 491281 tctggatggc gtagatgcgg taattgttac tcatctacac ctagatcact ttgatgatgt 491341 ggcaaaaaac gtattgccaa aaaacatcaa aatgtttgtt caaaatgaag cagatgcaaa 491401 agaagtaaaa gcaagtggtt tcaaaaatgt agaagtgcta catcaagaca ctgtttttga 491461 agggatccaa ttagtaaaaa caaaaggtga acatggcaga ggggaagagt tattaaactt 491521 aatgggtgat gtttgtggat tagtattcaa gcacccaagt gaaaaagttt tatatgtagc 491581 tggggataca gtttggtatg atgctatcga agacgagatt catacacatc aaccagaaat 491641 cattgtggtt aatggtggag acaatcaaag attagattta ggttcactca tcatgggaaa 491701 agaagacatc tatgaagttc acaaggctgc tcctcatgct aagattatat ctgttcatat 491761 ggaagctgtt aaccattgga cactatctag agaagaatta aaaaacttta gtaaagaaaa 491821 aggattctca agtaatattt tagtgccaga agatggcgag tcttacacat tttaatatga 491881 acaccgacaa ataaatagaa gaagctcata attataaaaa ctaatcatga gcttcttcta 491941 ataatgaata ttttaaattt taaatatatc gaaaatccta aatatacgga ataacaaaaa 492001 tggaatgttc caatgatgac aaaaaaactt gaaaagcaac aaagatgtgt cgttaggagg 492061 tagaattcat ggtaatgaca aaaaaagata caaatatatc aacacagcag cctctttggt 492121 tacaaggtta tattgattca ccagaaaaac aaaaccaact ttataaaaaa acattaaaaa 492181 tcttgatttt ttcacaaata tttgggggag caggacttgg agctgggata acagttgggg 492241 cgcttcttgc acaagatatg ataggatcgg aaaatgtagc aggaattcca actgccctct 492301 ttacttttgg atctgccgta gctgccctgc ttataggagc atcctcacaa cgttttggtc 492361 gcagagctgg acttgcaggt ggtttcctta taggcggatt aggtgctata ggtgtgataa 492421 tcgcggcttt aattaacagc gttgccctat tatttgtttc tcttcttatt tatggagcag 492481 gtatggcttc taatcttcaa gttcggtatg ctgggacaga ccttgcaaat gagaaacaac 492541 gggcaactgc tgcaagtatg gccttagttt ctactacttt aggagctgta gtaggtccta 492601 acttagttaa tacaatgggg gaatttgcag attcaattgg tgttcccaat ttagctggtc 492661 cgtttattat gtcaggagca gcttttataa ttgctggaat tattctctta atttttcttc 492721 gtccagatcc gctgtttgta tcaacagcta ttgcgaatgc tgagaaaaaa gacgataaag 492781 tacaaatagg aggaagtcta aaaaatcctg ctatagacaa aaaaggaata atggtaggag 492841 ctgtcattat gattttagct caactaatca tgacagctat tatgacaatg acaccggttc 492901 acatgggtca tcacggtcat ggtttaagcg aagtgggatt agttatagga ctccatattg 492961 cagcgatgta tcttccttca ccattgactg gtttattagt agataagttt ggtcgcacaa 493021 ctatggctat tgcttcaggt gccacacttc ttgccgctgg gttggtggca gctattgcac 493081 cggcagactc attatcattg ctaatcctag cactagtatt actaggggta ggttggaact 493141 ttggtttact aacgggaact gcccttatta tagattcaac acatccatct ctacgtgcaa 493201 aaacacaggg aacattcgat gttttattag cactatcagg agcagcaggt ggagccttgt 493261 caggaatggt tgttgcacat tctagttata caatactatc aatttctgga gccgttttat 493321 cattgttact cattccagta gttatttggt attttagaag gattcaggaa aaagcataag 493381 cttatataac tgtctttgaa gaacctaagt agacattact ttaccggaac ctcctttttc 493441 tatttattat agtaaggagt tgacatggca ttagtggcat gtgtataact acacaattat 493501 ttgggattca gagagcatgt aatgaacgga agagataatt atttatcact tttattattg 493561 tacggtgttc ttgtggcatt aagttcagtc aattttggtc taactgtttt ctttttgttt 493621 tcatcacctc tccatattat taacaaacac gaaaaggatt ttaatgaaaa taaaatgatt 493681 agcgtatgta tctctaattt tcaaaatgaa tgaatagtcc tttttaagat ttacacactt 493741 attctccaag gaaaaatgac tcaatttttc gattttttat gtaaatcaaa aaagaatcat 493801 gttagagtag gtgtgctgaa aataattcaa aaaattattt tgcgatatga ttaaagtaat 493861 attgccagag agtttcaatt ggacaaaatt gtaagtgttt aatacactgg ggctgcaatc 493921 aaatatgcac ctggaatcaa ttgctaaacg ggggagttta tatgaacaac aagaaaaata 493981 tctttgatat tgttatgtac attattttcg gtgtgttaag tctttttcta gttgcaaaaa 494041 ctgattatgg cactggagtt ttagtgtttg ttgcaatttt atacctcgct gttattgctt 494101 ataaaattaa gcaagtattt agtaattcag attcttaagg tgtaacacaa ggaggatttc 494161 aattgagaaa gaaaagagtt attacttgtg ttatggctgc atcattgact ttaggctcac 494221 ttttacctgc aggttacgct tctgcaaagg aggactctaa gacaacccct tcttacgaag 494281 aactagctct acattacaaa atgaaaagtg aaaagatttc atcgaacggg aaattagttg 494341 aaattgagta tgtgagtgga aatgaaactc acaaagttca gatgaacgga aataatcata 494401 ctgtaaaagt cgatggcata gaacaaaaag gtttaaactt tgagtatgat gaaaatgttg 494461 ctaaaagaac aaattatgaa aacaataatt tgaaatcaaa tgaattcaca acacaggctg 494521 caaaacctaa aaagggatac cattatgtgg ggactttatc tgggcataca aaagcagcta 494581 aaaatgcgtt atcagttaca atgtcattag tcggtattgt ccctggcttg ggatggggga 494641 gtaaggctgc cactatttta ttctcttatt gggcaaaaga acaaatccct gatgcgtatt 494701 ataaatatga tttatacgaa aaaggagcaa tgactgatag ttggtatcag tatgctacag 494761 ttcaattttt tgaagataaa gctcataaaa agaaaatggg caaaccttgg acaagtactc 494821 ctgcaaaagt agatttacct aatagctaat tttaaaatca ctttgtcttt ataaaggaca 494881 aagtgatttt ttgttataca gaagtaaaat ccctcgtctg aggaatcttg gaaaaaactt 494941 ggttcaattt tgatataaca tgtttttttc ttgctaattt agtttttcta tgtatcgcta 495001 cacattctaa ataataagat attagccgga cggttgatgc caagctcaaa agtttatatg 495061 gaagtcaaag cataaaaaag ggtgttacaa cgtgtagtct tctttttatt ttgccaacgt 495121 aacaagtgtg aaagtaatga tttgtaggat cagttaagaa aggtttaaga ttagatattg 495181 aaaaatttta tatattttca ataaaatact ggtactataa taaatgtata cagattgtat 495241 ggagatgtaa ttaattaaaa aggagttttt taattgcgtt ggagtaaatg gttcaatgtt 495301 ttttgtatag tagcattggg atcaatatat ggttataaat tatttactaa ccaagaagtc 495361 agtactactc gtttaataat agcttctgta attgtgttgt ggaatattgt tggacttttt 495421 agcaaagaat cagtaaaaca agcacagcaa gcaaattaaa agtcataaag ttgggaaaga 495481 aggatgttac ttatgtagta tccttcttta ttattccttg aaaaatgaaa caaattggag 495541 attacagctt atataatcaa ttgaagtcgt tgattatttt catgaacagg agatttaatg 495601 ctttctgatg aaatattatc gtatgaatgt tgcaagagga aacgttactc aaagattaca 495661 gggatgtgat gaacactcct ctttatcgca ctcacctgac cccaaattgt tggggaaggg 495721 caggtacgga agatagagta ttttttcttc gtaacaaatc gaaaaggttg gataataaaa 495781 aacttataat ctaaggcggt atatagttgt gaaaaaggcg ttatttctta tattagacca 495841 gtatgcagat tgggaaggtg tttacttagc atctgcatta aatcaaagag aagattggtc 495901 ggttcacact gtttctttag accctattgt aagctcaata ggtggtttta aaacatctgt 495961 cgattacata atagggttag aacctgcaaa ttttaatttg ctagttatga ttggcgggga 496021 ttcctggagt aatgacaata aaaaactatt acattttgta aaaactgcat ttcaaaaaaa 496081 cattccaata gcagcgatat gcggtgcagt ggattttttg gcgaagaatg gtttgctgaa 496141 taatcatagc catacaggta attttgttta cttatggaaa gattacaaac aatataaacc 496201 gattagcagt tttgtagaga aacaagcagt aagagataaa aatttggtta ctgctaatgg 496261 aactgcccct attgaattta ctaatttaat tttagagatg attgattttg atactcctga 496321 gaacatagag aaaatgatgt atatgaatcg ttatggtttt tatcattttt gtgataaata 496381 tggaaatcca tttgttgatt aatttgctgg aaatgatttt cccgaatagg gggctttgcg 496441 attgagttga atttcctaat aaagcaaaga aagatgattt gaggtcaagt ttaacaaata 496501 atgccatcaa tattaatttg cagttatttc cgattcctga tataataaag aagaattatt 496561 tttgttcggt gtaaaggata gtatgaagat tgacttttcg tcttgatgat actttgggca 496621 aggatagtat atactgtgtg gttacacact aggaggcaac aaaaatggaa caaggtacag 496681 ttaaatggtt taatgcagaa aaaggttttg gctttatcga acgcgaaaat ggagacgatg 496741 tattcgtaca cttttctgca atccaaagtg acggattcaa atctttagac gaaggtcaaa 496801 aagtatcgtt tgacgttgag caaggtgctc gtggagctca agctgctaac gttcaaaaag 496861 cttaatcttc aatcgtttat acaaacaggc tctttatata gggcctgttt ttttatgtct 496921 atatcatact caataaaaaa ccctactcaa cgttcgagta gggagatgct acaaggtaat 496981 agaaaaagat ttaaaacttc aaaggtttgt ttacagtata acatactgga ttgacaatat 497041 gcggaatgta tataaattat ttaatgtttt gttcaaatat agataactga ctcttttttt 497101 cactaacctg ttcgttcatt taagtaagat tagatgaatt ataaaaatgg tttcatctaa 497161 atgttatcaa ctcgcatatc tcttttatga gaagaagata aacaattatt attcaatgtt 497221 gcagtggata taagaaattc ttaaaaataa tgaggagatc gattgttttt ttctcctgga 497281 aataatcact tagagatacc taaaacaatg aaagccctac ctctcttcca tccttacggc 497341 tccttgtccg tgccagtgtg aatcaggata ctaaaaaaag tgactatttt attgagtttt 497401 ttggtaaaac ttcaatcttc gcagaagaaa tgtaaataat aaaaatggat tagaatgtag 497461 gaataacaaa agaggtcgtt aatgttctaa acataagttg gagaagattt gcttttcatc 497521 ataatattcc gaaatatctt ttgggatgta tctaaccaaa actttttatt tgtttttcag 497581 tgattccttt aattacttcc agttcactaa tcaaaaattc atatgcatta tccagcattt 497641 ttttttcgct tgcattaagt gctttttctt tcttcatacg cattaaatca cgtacaactt 497701 cagcaccttc ttgtatttca cctgttttta ttttgtccgt gtttattttg tacctttgct 497761 tccatggcag taacctatcg gattctccat gctgaaaaat gtgcataatg tgttttaatg 497821 caagtatatc ggtaactggt cgtatattcg aactcaatat tttactcgtt ggaatcataa 497881 ctgtcatatt actgattgac attcttatga cataatactg ttgtttttcc tctaagaatt 497941 ctttttcttc tatggcttca attatacctg ctccgtgcat tggataaaca atgttatcgc 498001 caatttgaaa catatcatcc acctccatat atggtatcct tcttaagatt accatatatg 498061 gaggtgtaat atcaaaattt taataataac atgatcgaat ttttgatgtc aataactttt 498121 ttgaaaaaac agatcaagca aaaacaatag ggaacgtgtc ggatttccaa tcaggaaaag 498181 gtcaattgat ccgtgtgagc agtttttcat tggctcaatg acattacaga aatgatttga 498241 gtagataaga aagaacgata ttcgtgaaat gtcagctaaa aatatttaaa gcacatgatt 498301 aagttctaat ttctttaccg atttgatatg gataacggcc gacttactta atgatgcatt 498361 ttcacttatc ttgcaagcag aaaaaggttt gttgataaac atttagccac caaattggca 498421 ttattatcag ggaaattgac aaccttcaaa tgggtattga ggcgagaaga aaaataaaga 498481 aaggagagat tataaatgaa gaccagaaca taaagaagta aaggggaaag aacaaggtta 498541 attgaaaagc aaactatata aaatagtttg cttttttttg ttatgacttc acttcttttt 498601 ctttctcttt aatgactaat aaaacaccgc tcagaattaa aaacgaacct atccaaaatg 498661 tcccgcctat ttgttctcca agcagaatcc atccgagtaa ggttccaacc agaggctgaa 498721 aaaagaaaaa gaggcctcca cttgaggcat ttaataattg taagccgtgg ttccacaata 498781 aaaatgcaca agctgttgaa acaattccca aatacaaaag gccacctaga attttagggt 498841 caagcagtag tggcgtaaaa atcgtgctag gggagtacca ttaacaggga ctccatttat 498901 taatagaata aactttatga attcattttt ttgtatgata atggcgtcat attcatcgct 498961 tgttgaaatt tacttatgaa ataactggta ctgttaaatc caacttgata agacacttct 499021 gtcacattgg attcagggtg ttgcagtaat aataagcttt tttgaattct ataatccatt 499081 acataacgta atggcgtctt attcagcatt cgtttaaaat aacggcagca ttcagaacgg 499141 ctcagttggc cagcttttgc aatgtcctct aatgtgattt tttcaacata atggagatgg 499201 atccagttta acatttgttt cattcgatga ctttttatca tttcagattg atcgtactct 499261 aattgaaaac cattaacgac caggtttttc cacattaacg ttaattgcat cgtaatgtca 499321 atctcataga gcgatgtctt ttgttgaatc aattgattta tttttttaac agcatctaga 499381 atattttttg cccactgttg atttccagcc aaaaataaat agggcaaatt ggttgaaaac 499441 atatagggct gaacatagct tgaatacagt tcctgagata aaacgaaatg gggtgacaca 499501 ttcaagcaaa tatacgtaca atccgagcct tccttttctt cggccatgtg caggtagccg 499561 ctattgataa ataatccatc cccttcgtga acctctattt tttcttcatt tatttgaaag 499621 agagctatcc cttttagtat caaaacaaat tggatttcat catgccaatg aagcggaata 499681 tagccattta tattttgatt gatcgttgtc ttgtagcagg caactggcaa ttctaccgtt 499741 cggtgctctg ttaattcttt taaattttga tcgatcacaa aattcttcat tctgacttca 499801 cacctcaata tatttatatt ttttcattca atttgagtat tttttatcat gttttgcatt 499861 tattataaca ctattattat atttattagt gaggagtcat gtatgaatac ttccaataga 499921 agaatgggat tgttctatgt tatcacaggg gcgacatgtt gggggattgg aggcacagta 499981 gccaaaaaac tttttcaaga atatcaaatt gatgtcaatt ggcttgtaac gacacgcttg 500041 cttacggctg gaatgttact tttaatgctg caactgttca gaaaggatcg ttcccaggtt 500101 attgaggtgt ggaaacacaa agcgtcggct ggccagcttc taatttttgg cctattggga 500161 atgctagctg tgcagtacac atatatggca tccattcaac atgggaatgc tgccgttgct 500221 acgttattgc aatatttatc cccagtaatc gtcattatct acacgctgtt gcgaaaacaa 500281 acggttctta ccaaacaaga tatcataact gttgtacttg ctttagtggg ttgctttttt 500341 ttgttaacaa atggttcaat gtctcaactt tcagtgccgg cagctgcagt agtatgggga 500401 gttttatcag gattcgcggc agctttttat actttgtatg ccgttggttt attaaataaa 500461 tttgattctc ttgtcgttgt aggttgggct atgattattg gcggttttgc attgggtttt 500521 atccatccgc catggcaact ggattttcaa cgattaactg ctgaggcgta tgcatatatc 500581 ttattcgtga tattatttgg aacaatgatt gcgttctggt tcttcataaa aagcttggaa 500641 agcctctctc caaaagaaac aagcctacta ggcagtctag agcctctatc agctgttgta 500701 acaactgtcg tttggttaaa agcgccattt ggttcttttc aatggattgg tgctatttgt 500761 attataggga taactttaat attggcttta cataaagagc cttctatgga gagtgaaaaa 500821 tcgatattaa agattaggaa tcatgcaaat cgggatatat aggggctttt tttgcttaca 500881 tgaccggtcc ggcaatgaaa aacactggtg gagtttgagc cctctcggca gtatcaaaaa 500941 taccaagggt tttgacgccc taggtatttt ttcttcaaga accttcaatt tttcttctct 501001 gattgaaaaa cgtattactt ttttgtgatt ggtatccaaa tttcactttt aaaagatggt 501061 gatgttacat ccttatgctc gttccacaat atttctggac cttctatttg ttcgtaattt 501121 gacgatggaa accattcgga ataaatgcgt ccccatactt cttgcagtgt atccggaaat 501181 ggcccgattg attcgaatac agcccatgtt gaggcaggaa cttcaagccg tgagaagtta 501241 tctggacacc gtttcgttgt ggctgcgcca atatagtgat cgagctctcc gttttcctct 501301 gtccgacctt cagaaaaatt cgtggatgca ctaatgaggc ctgatggtgc tacattagat 501361 agctctttta gtttatttat tgctttttca tctaaacttt cccacataga tgcaatttcc 501421 ggattaattc ctttgaaaat aataggaact ctttttttaa tgccaacgat gcgaaatgcc 501481 tctttttctt caatacggta gttcatttca tttcctcctt taattgttag ctggaaggtc 501541 attcgtggat aagctttaag ggaatggcca ttaaatctgg cttttgatgg gtttatgcca 501601 tgtaaatttt ggaatgcccg tgcaaaagaa tctggtgagt tataaccgta ctttattgca 501661 atatcaatca cttttacatt gctgtctttc agttcaaaag ctgcaagagt aagacgtctg 501721 cgacgaatat attccgataa tgaaatacct gcaaggaagg aaaacatcct tttaaaatga 501781 tattcagagc agaaagcaag ctttgctgcc tcttgaaaat caatatcatt agtgaggttt 501841 tcttcaatat actttaacgc cctattcata cttttaagca aatccattta tttggcctcc 501901 tttaaccaaa gaataacagg agtgaaatgt atttatccga cattctgtgc acagttttgc 501961 aggatgactt atatgaaata aagtaagtga ttcacttgta tttgtacagg ttttattgaa 502021 gcatgctgtt cataaaaagg catcaataaa agaaagttat aattgtctta taaacggcac 502081 attcatataa ttgagtgaaa aaggatgcgt atcatgccta tcaattcttt tgaaaattat 502141 ccgatgagct ggaagccatc gattgataaa gctgaaaagc ctatttataa agcacttgca 502201 gggcaattgg aacaggatat tttaaacgga gttttattac ctggaacaaa acttcctcca 502261 cagcgagaat tggccgatta tctagattta aatgtgagta cgatttcaaa agcatttaaa 502321 gtgtgtgagt taaaagggct gctgagtgcg actgtaggga gcggcacatt tgtatcgtat 502381 gatgcgttgt cgaatgcgta tttacttgag gatactaagc cgacacattt aattgaaatg 502441 ggagcaatac ttccagatca cgcttcatat gagcccttgt tataccaact gaaaaacatg 502501 gttcatgagg aggattatga aaaatggttt agctatggcc gggcaggtga aagcctttgg 502561 caaaaagatg cagctgtaaa gctcatccaa agaggcggat ttgaaacatc cgttgatcac 502621 attttatttg caaatggagg gcaaaatgcg attgcagcga cattggcgag tctttgtaag 502681 cctggagatc gcatcggagt tgaccatcat acgtaccctg gattaaaaac tgttgcatca 502741 ttgcttagtg tgcaaatcgt accgataaaa tcagaaaacg atgaaatgag tccggagtca 502801 cttgaatatg cgtgtaaaaa cgaaaatatt aaaggtttgt atttaatccc ggattatcat 502861 aatccgacga cttcctttat gtctgttgag aatcgaagaa tggttgcaga cattgtaaag 502921 aaatataatc tgtttgttat tgaggatgca tcgtaccatc ttctcaacaa aaatccgctt 502981 ccggcactcg cctcattcgc accgcaacag gttattcata ttgcaagttt atcaaaatcg 503041 ttagcgccag gcctgcgttt ggcttatgta gcagtgccga gacaatataa ggagccaata 503101 tcaaaggcgc tttataattt aaatataact gtttccccgc tattagctga acttactgct 503161 cgcacgattg tatcaaatca atttgaagtc ttaattgaga gtcatcgtga acaaaccatt 503221 cgcagaaatc aactcgtaaa ccgatatgtt gcgggatata catgtttagg tgttgaaaca 503281 ggcatttttc gttggttgtt gttaccgggt aaaatgtctg gtgccgaatt tgaagaattg 503341 gctgctcgac ttggcgtgca agtgtatgcg gctgaacgct ttgtagtggg aaatagttgt 503401 cctgaaaggg ctgtaagggt ttctgtctgt gcaccaaaaa cacttgaaga gcttgaacaa 503461 ggattaatga tcctgagacg tttgctagac gatcttacct aatattgttt gccatacaat 503521 tatgacattg tatggctttt ttgtgcgtgt tatgatgatc cacatctaga gggaggttta 503581 tacaaaattg gcttttagaa aggaaggtca gatgatgtta gacaaggaca gcgtaaaagc 503641 aatagatgtt caaactgctt cattacagag ctacatcagt tcaccagaaa aacaaaaatc 503701 gttatacaag cgtacactat tcgttgtgag tatctcacaa atttttggcg gtgcggggct 503761 ggcggcagga gtgactgtcg gtgcgcttat tgcacagcaa atgcttggca ctgatgcgtt 503821 tgctggtttg ccttctgctt tatttacttt agggtcagca ggatctgcat taattgttgg 503881 aagactttct caacgttatg gccgtcgaac aggtctttca gctggcttta tgattggcgg 503941 acttggagca ataggcgtta ttatggcagc aatcataaat agtattttct tgttatttat 504001 ttcgttgctt atttacggtg caggtacagc cactaattta caggcccgtt atgcaggtac 504061 agacttagca aatcataagc agcgagcgac tgctgttagt ataaccatgg tttttactac 504121 atttggcgca gtggcaggtc caagcttagt gaatgtgatg ggggatttcg ctctttctat 504181 tggtgttcca tcacttgctg gccctttcat tttagccgca gcagcatata tgttagcagg 504241 tgtggtcctt ttcattatgc ttcgtccaga tccattagtt atagcaagaa caatagaagc 504301 ggcaaatgaa gagcctggtg ataaaggaca tttggcggca actgagcata cagaaaacaa 504361 aaaagggata atcgttgggg caacggttat ggttcttacc caaatagtaa tggtagctat 504421 tatgacaatg acaccggttc atatgagaca tcatgggcat gacttgggtg cagtcggtct 504481 tgttattggt tttcatatag gtgctatgta tctcccttca cttgttacag gtgttcttgt 504541 agataggttg ggacgtaccg caatggctat ttcctctgga acaacgttgc ttttggcagg 504601 tgtaatagca gcatttgctc cgggagaatc tatgattctt ctcgtcattg ctctttcttt 504661 actgggatta gggtggaatt ttggtttgat aagcgggact gcccttattg tagattcaac 504721 tgatactgcc acacgagcta aaacgcaggg gacagtggat gttctgattg cgttgtcagg 504781 agctgctggc ggagcattat ctggaatgat tgtggcaggt tcaagttacc tcgcattatc 504841 acttattgga gggattttgt ccttattact cattccggtg gtggtatggt ctaggggccg 504901 ctaaagggta ggattgttta atttacatta atttgttata ttgttagata aagtatattg 504961 cagcatctaa tattctaacg aactatagtt gctccattaa atctattata aagatttgac 505021 caggattcct tatagctgtg tcactcactg catattcttt aattgaatca cataaaatgg 505081 ttatcggatt tgaaaaaggc aggattactc gctttaggta aaggagtcat aacgttgtta 505141 aaaaggtttt ctcttgttat tgttacacta atgatgtcta tcgttgttgt tttagcggct 505201 gctaaagagt cgcctggaga tcatgtcatc tcatttgatg aacctattat cttgatgatc 505261 tcaattggaa tcgttgtatt tttattgatc cctccattag tcatgtcctt ttttggcaat 505321 ttggttgtaa gaataatatc tggtgtatac caatgtttta tcgttttcac ttttctgggg 505381 ctcattccaa ttggatttct tattcccaat ggctttttga caattctagt ttctattgca 505441 ggaactttag tcagtatagc tagtgttgcc gtaaccttat gcattggcaa gaataaaaaa 505501 gatatataat catcgaattg ttattttttc agattgtcag tgaaataatt atacaaaaag 505561 agaaggcttg tgggccttct ttttttgttg ttgcatcatc cccactttga gcttaatcta 505621 ttgaataata agagaaggaa cctatagaag aataaaataa ataccgagat gtcaaaaata 505681 aaactggact tcattattgt gaattcacgt aaatgtaaaa agattggaaa gaggggaatt 505741 ccttcatgac aaatagcaga acaaatccga aggttgatga atttttaagt aaagcgaaaa 505801 agtggaagga agaatttgag aagttgagaa ccatcattct tgactgtgag ctgactgaag 505861 attttaagtg gatgcatcct tgttacacat atcataataa aaatattgtt ttaatacatg 505921 ggtttaaaga atattgcgcg cttctgttcc acaaaggcgt cttattacag gatacagatg 505981 gaattctcat tcaacaaacg gagaatgtac aggcggcgcg ccagattcgg tttacaaatg 506041 ttcaggaaat aaatgagcta gaaaacattt tgaaagccta tattcacgaa gccattgaag 506101 ttgaaaaagc cggtttgaaa gtggatgtta acaaaaatat tgaattgaac attcctgaag 506161 aacttcaaaa taaattcgat gaaatccctg cattgaaaat tgcttttgaa gctttgaccc 506221 cgggacggca aagagcgtac actctttatt tttctcaagc caaacaatcc aaaacccgag 506281 aatcgagagt cgaaaaatat gtgcaaaaaa ttctcgatgg aaagggatta aaggattagg 506341 cacgccaagg ttcaggctaa aggaatagca tcatagcgta ataagatcat ttctatagaa 506401 gaaaaacaag catagtaaga tgcttgtttt ttcttaggac aacattcact tactgctgaa 506461 atgcttctaa cattgtatgc cactagacag cgttataaaa tattaatgca acacctagaa 506521 atctatccaa tgaaatagct caatggtatg gctcattaca tttagaatgc ctaggagaac 506581 taatagaacc ggaagatttt tagcaagtta ctacactcca aactttgttt ttgtattaat 506641 ataccttatt aaccattgtt tttagtcagg tgcagacaaa cgaatactga ttaatgaatc 506701 atcatgatat caatgagccg cttgattttt tcatcgtcgc ctgtatcaac gtacactgtt 506761 tttctgtttt ttatgatact ctcagtcact tcccgcatga cgcctttttc tatatcatca 506821 gcggaatccc agcgtaaagg cacattatat acatgaattg tgccatcccc attgccatga 506881 taagtgactg atccatccac taaacgagaa cctgccaact gggtcacatt ttctggatag 506941 ctggcacttg tatcatcatt aggattaatt ggctcgccag ccgcaatatg tcgaacattt 507001 aattcatcta tctcttgatt aggtccaagt tgaagccaaa ctctggcata ttcaattttt 507061 tccgaagagt atgctgccaa tacattgtct tctttgcttt tctcttctgc tgaagaggta 507121 tcatttgcag cttttgttgc ggattcttct gattctgtta ttggctccgc ttcatccttg 507181 cgtattttgg tgctctcttc aggctcagtg tgtttttcgt cagtttgcac agcagaagct 507241 tgatttgaag gttgttgtgc ttctccatcc ttactgtccg tacatccagc aagcaaaatc 507301 ataagcagca gggcagtatt gcaataacat atctttctgc gtttcttcat tttttcattc 507361 ctctctatta attcaggtca gcttcatata taagtttatg tatctaaata ttaccatgga 507421 atagatagga tgatattgaa aactgtttaa gaagaggaaa cgatcttgaa tagcatcgcg 507481 aaaacctaag aatcttaaga agttttgccc ctttttcttc aggtattgaa tgtaaagtgg 507541 gatataaatg caaacaaaaa cgaaatgcct tatccacctc gtgtcatggc agaaaaagtg 507601 ggggatttat tagagcggat ttgataatgg cggcaggtaa atgggtgttg acttatatgt 507661 ctaagcggga gactcaagtc tgctcgatcg catacaaaat accaagggcc agcaaccctt 507721 ggtattttta taccttcatg catttttgaa gtttatgctt aaaggtctgc cttactttgc 507781 aaatcgccga gctgctgcaa cgcacatgat aacggcgata ttcactgcta cgagtgccca 507841 gcccactttc tcgtgcagaa tcactgaggc aagcagcagt ccaaaaaaag gctggagaag 507901 ctggagctgc ccaaccgctg caattccccc ttgggcaaga cctcgatacc agaacacgaa 507961 gccaatcagc atgctgaata aggatacata tgcaagactg agcagtgcgg gaacgccgat 508021 cgccgaccat gagtccggcg taaaaaagaa cgacaatggc agcataagag gaagcgacag 508081 aacgagtgcc catgagatca cctgccaatt ccccagacgc cgtgaaagtt tggccccttc 508141 tgcataacca agaccgcata cgacaataga agccagcatg tacgcgtcgc caagcgggga 508201 tgaacctccc ccctgaatga gggcgaaacc tgctactaac aagctgccgg cagctgagaa 508261 aatccagaag acggggcgag ggcgttcacc cccgcgcagt acgccgaaga ctgccgttgc 508321 gagtggaaga agtccaatga agacaatggc gtgtgcggat gtgacatgct gaagcgctaa 508381 agctgtcagc aacgggaaac caatcactac gccgaacgct accactaaca atgaaatgag 508441 atctcttttg gcaggatgct gctgccggaa gatgagaagg agacctcccg ccagtacacc 508501 agctatcgca gcacggcaaa ctgtgagaaa taacggatcg aagtctgaca cagccaaacg 508561 ggtcgcaggc agcgagccgc tgaaaatgag tacgcctata aaaccattta tccagccatt 508621 tgttgttttg ttcattataa tcactccaca tatctttctt gttcattgtc tgtattttct 508681 taacaaaacc agcagctaag gattacaatg actataaact ggaattggcc ttttataaac 508741 agccagtttt cataaaaaaa tgcataccag ttaggagaac aacgcgcaaa tggatatcac 508801 gccttttttg aatagaactc tggatattcc gctttatcag cagctttatc ggtattttaa 508861 agaaaatatg catcggggcc gtattcaaaa aggaatgaag cttccttcaa aaagactcct 508921 ggcgaatcag ctttccatca gccaaacgac tgtagaacgt gcctatgaac agctcgctgc 508981 tgaaggttat attgtgagca agccaagaag cgggtggttt gctgattatc atgattctga 509041 ttttgcttat gatagaatgc caagcacaac acccattcaa caagaagcag aagaaaataa 509101 acaatggatt gattttcatt atgggaatgt agattcttct tacttccctt tttccgcatg 509161 gcgaaaaagc atggtcaata gcttagacca atatggacac gagctttatc ggccgggaca 509221 tgttttagga gagtttgagc tgagaacact cattgcagag tacctgtatc aatctcgggg 509281 ggttcattgc ggccctgaac aagtgattat aggtgccggg aaccctattc tgctgcaaat 509341 cttgtgccaa gtttttgagc cgaatatttc tatagggtat gaggatcctg gttatccaag 509401 agcacgcaag atttttgaag ccaaccgcat gaatattgtt cctataccag tcgatgatga 509461 gggaatctgt atacagaaga tcaaagaaca gcagccaaac cttgtatatg tcacaccttc 509521 ccatcaattt acgctgggaa ccataatgac aataaacaga agaattcagc tgctcaaatg 509581 ggcggccgaa aatcaatcct ttatcataga ggatgattat gacggggaat ttaggtacac 509641 aggacagccg gttccttctc tgcaagggct tgatcagcat aaccgtgtca tttatatggg 509701 cactttttct aagtctcttt tgccctcgct gcgtatcagc tatatgattc ttccttcgcc 509761 tcttttaaaa aagggtcatg aaatcacgtc cttatataag cagacagtgt cctgccacag 509821 tcagctaacc ctagctgaat ttataaaaaa tggagagtgg caaaaacaca tcaacagaat 509881 gagaaaactt taccgcaaaa aaagagccat tgtattagag gcagtgcaaa gggaattagg 509941 agagcatgtc agaatccgcg gagaaaactc tgggcttcgt atcttacttg acgtttattt 510001 gccatttggt gaaaaagagt taattgagaa ggcgaaaaaa catggagtaa aaatttatcc 510061 tgtttctctt tcttatcaac atcatcctcc tacaaaaacg gtctcgctcg ggtttgcagg 510121 ggtttctgaa tccgacataa gagaaggcat aaaaaaactg aaggctgcct ggaagatatg 510181 agggagcttt cagtttagca aaacggccaa gtgacgacta agtgttgaga gctgttcaat 510241 attttttaag tatatgatga gtgcctgcag tccaggccac gatacgtctg tttagcgaaa 510301 aacagaattt tttatttgct cctcacagtg ctaaaataaa caaaatagac aattgaaaaa 510361 atagaggtgt aagaatgaag ttagatgagt ttacaattgg ccaggtcttc aaaacgaaat 510421 cattaaaagt atcaaaagat gatattatgc ggtttgcggg tgaatttgac cctcagtata 510481 tgcatgtaga tgaagaaaaa gcgagtaaag gcagatttaa tggaattatc gcttccggca 510541 tacaaacact ggccatatct tttaaacttt ggattgaaga aggtttctat ggagacgata 510601 ttatagccgg aacagagatg aatcatatga cattcataaa acccgtatat ccggatgatg 510661 aattgtttac aattgttgag gttcttgata agcagccaaa gagaaatgaa ttgggaatac 510721 tcacagtatt gctatctact tataatcaaa aagaagtaaa agtgtttgaa ggtgagttat 510781 ctgtattgat caaacgataa ctcagaaagc ccgcttttcg cgggctcgat tgaagcagat 510841 gggtgaaaga tgttagcggg tttcctttga aaaataagag gttaaaacat cataaacaat 510901 aggcaaagaa gtaaatccct catcttctag aaaatgacct ccgtgctgaa cttcatataa 510961 cgcagcatca atttgttgtg ccagatcctt gctgaatgaa aaaggcacaa tttggtcgtc 511021 cttagaagca atgacagcac ggtgcttcgc ggactcgatg attttttgat gatcaaacga 511081 tccctgtgta aattcatcta acatctgtaa agtgggcaat gatttggcaa agccggaaac 511141 aagtatgatt ccgccaagct gttttcgtaa ttgaagatgt tccaaaaatc tcaaaatggc 511201 ggggcaacct aagctgtgcg caaccaaata cgtattttca tgtaaagtgt gctgatataa 511261 agagagtgta tccagccaat cctcaagtct tggctggagc ggattaggca tgtttaaaat 511321 gtctgcttgg accccatctg cgagcagacg ttttttcagc caagggaacc aatgatttgt 511381 tgaggaggct ctgtagccat gaatgatata gacttgtttt gtcattattt cctcctaaga 511441 aatattttca ttcagtataa aattcctctc attgggaaac aagtacgcac ttttttgtaa 511501 gtagctttac atatgaggcc ctccttgtgc cattccccac ttacacatct catctatgag 511561 gggatacaaa gatcgccctc tgtcagataa cgaatactct actttcagtg gggtgtgaga 511621 aacctcagac cgatgaataa ggccgtcagt ttgcaattcc ttaagctgtg cgcttaacat 511681 tttatgggtg atgaagggca tagccctttt cagctcgccg tatctcatcg ttttttcaca 511741 ccctaactca tagagaattc tcattttcca tttgccccct ataagagata aggtgtattc 511801 aaatggggct tgtttactgc ggcacaggct attcattgta atcaaacctc cttttttaag 511861 tatcatatca gaataaatta ggattttcgg tgttgaagtt tgagggcgat tcacgatctg 511921 aagtgaaagg ggccgcttgc tcaacaggcg gcacggtaca tgaatgttct aagtcaaaga 511981 gggttacctt actgttagtt actttattta aaaaaacgca tgtttttagc tgaaaatatc 512041 tattatggta tatttaaata taaagaaata tttgagaaat gaggaatggt atgaatacac 512101 ccaaaaaaca taagaaattt aaagcgaaaa tgattctcca aatcatcatg gttatcattg 512161 gaggaatcat agcggcatat ggactagaaa cagtgctcat tccaaacagt gtatctgatg 512221 gaggggtgac gggtcttagc atcgttggtt cacagctatt caacttgccg ctggggattt 512281 tgattgctgt gatcaacatt ccatttgtct ggttaggata taagcaaatt gggaaaagct 512341 ttgcattatt atcaattatc ggaatcgtat cgcttgccgc ggggacaagc tttttccacc 512401 acacacccgc tatcatagaa ggagataccc tgttaattac cgttgtcggc gggattatcc 512461 ttggattcgg aatggggctg gcgctgcgta atggcggcgc attagatgga attgacatgc 512521 ttgctgtgct gctatcccga aaactgccat tcggaacgag cgatctcatt ctattcttaa 512581 acctatttgt gtttattttt gtttccacag tatttggctt acaaggggca ttgctttcag 512641 tcattgctta ctacattgca tccaaagtga ttcatgttgt ggaggaaggc ttaagcggct 512701 ctaaaacctt tcaaattatt acaacccaac ctgaattaat ggtagagaca atacgtgatc 512761 aattaggccg aagcgccaca tataaagaag cttacggggg tttttcccac gagaaattta 512821 aagaaatcac atgtgtcatc aaccgtttag aagaaaccaa actaaaggaa attattaatg 512881 atattgataa aactgccttt gttaccgtgt atgatgtagc tgaagtgaag ggcagcaatt 512941 ttagaaatct taatcatcac taaaaaatag aatgaccttt ttaaccgtaa ctgacatgcc 513001 gcgggtaatt taatcaaaaa cacttttttg aggcttgtgg gtgaataacc ggtgaaggtc 513061 tgaatcacag aaataccaag ggcgtcaaaa cccttggtat tttttctggt tattagattt 513121 tatcttcagc tttacgtgct gcttcgagct tatcaatcct gtctttatat ttttctcccc 513181 agtccttcat gtgcaggata acaggttcta atgttcttcc aaactcagtt aaagagtatt 513241 cgacttttgg agggacctgt ttataaacct cgcggtgaat cacgccatcc cgttccaatt 513301 ctcttaattg tagcgtgagc atacgctggg taatttttgg gtatagtttt cgaaactcat 513361 taaacctctt tttaccgtca atgagatgat aaagaagaat gcctttccac ttacctccga 513421 tgatatctaa tgttgtctcc accggacatc cttcaaagtc atcagaagaa taatcaatgc 513481 cgagtttacg atttctcaag ctgttcactc ctaatagtat actttttgat actatataca 513541 ttcaatgtgc gtacttttta tattttaata tacatcatat aatgatgtca catctaagga 513601 atgaaaggaa tggatcatat gaaaacactc gtactcgttg tacatccgaa tatagaatcc 513661 tctcgtatca ataaaaagtg gaaagaagcc gttttaagtg aaccagatgt aactgtccat 513721 gatctttatg aaaaatatcg cgatcaacca attgatgtgg aatttgaaca acagcagctc 513781 ctggcccatg accgtatcgt ttttcagttt ccattatact ggtacagcag cccaccgctt 513841 ttaaaacagt ggtttgatga agtgtttacg tttggctggg ctcatggtcc cggcggaaat 513901 aaattgaagg ggaaagagtg ggtaactgcc atgtccatcg gttcacctga acactcttat 513961 caagccggcg gatataactt gttttcgata agcgagctga caaaaccgtt ccaagcatct 514021 gcccatttag taggcatgac ctatctgcct tcctttgccg aatatcgcgc caatacaatc 514081 agtgaccaag aaattgccga aagtgcgaat cggtatgtaa agcatattac aaatatagaa 514141 ttaaacccga aggttcgcct gcaaaggtat ttgaaacagc tggagagtgt cgatttaaca 514201 taaagattga tttttgaaaa tcctgtactc accaagcagg attttttctt gttcagcaga 514261 gggattttaa catatagcaa aaaaagaaga agccaccaaa aataagctat ttgcttggtc 514321 ctgactgctt atttttggtg aaatacttat ttctctgtga tgaaataaag caaagcgatg 514381 accggaaaag cgattccaat ccataatgct gtactccatc cgcctgaggc atatgcccat 514441 cctccaattg atgaccctat cgcaccgcct agaaagaaga tcgccatgaa taatccgttt 514501 aatcgactgc gaatttcagg cgccaacgaa aaaatagcac gttgactgag cacaaggttt 514561 gcagatacac ccatatctaa cagaatagca gcggccacta gaactgttat accgacgggg 514621 gagctgctct gaatcatgag cggcagtaat aaagagacaa cgacaacacc gagagcgatt 514681 ccagtggcaa gcctggttaa gcctcgatca gccaggcggc cgcctattgg tgcagtgact 514741 gcacccgcaa tgcccaccaa tgcgtagagt gctattgcct tctgagaaaa atgaaaatca 514801 ggaccggaca ataataaagg aacagttgtc cagaacaagc tgaaagctcc aaatacaaac 514861 gcatgataga tggcacggcg gcgtaagact ggagtcgtgc gcagcagctt ccacattgaa 514921 ccgagtaagg cagtatagtt tgtatttgct gttggttttc tggcaggaag cacttttgat 514981 aatacgatgg ccaggataac acttaccacg gcggacaaag cgaatattgc attccacccc 515041 cagatatcag cgactagact agatatcgga cgggaaagca taataccgag taataagccg 515101 ctcatgacat tgccaacaac ccggccgcgt gcagcgtctg atgcaaggta tgatgcaaat 515161 ggaacaagca cttgggctgc gattgatccc aatccgacga aaaacgcagc tgctaaaaac 515221 agtgttccat gcttcacaaa tgctgttagt gtcaaagccg ctgcgcttag aaggagcgat 515281 acaacaataa gttttttgtt ttcgataata tctcctaaag ggacaaggaa tagtaagccg 515341 gcaacgtatc cgatttgggt gagtgtgaca atcaatccag caccgcttgg agaaagtcca 515401 attgccttac taattaatcc gaccaagggt tgtgcatagt aaagattagc aacaatgata 515461 ccgcatgcag ttgcgagaag aagggttaaa ctgggtgaaa tcctctgacc tgcttgtttg 515521 tttccattag ccatatgaat gaactccttt ttaagtggtt ttttgagtgt aatcatgact 515581 tctcacaagt gattttataa actgaacgtt cagtttcgtc gattaataaa aataatatac 515641 taaacgttca gttttgtaaa tggatttctg ttttcttttt ttattcaatt taagtatact 515701 gaacgtatag tttatattgc gggaaggaat gatttatgtg cagagtaaac gagggcggcc 515761 gcgtgatgaa ggaacgcata aggcgattct ctctgcagcc tatgacctat tgctggaaaa 515821 aggcttcgat gcggtgacag tcgataaaat tgccgagcgt gcgaaagtga gtaaagcaac 515881 gatttataaa tggtggtcta acaaggctgc cgttatcatg gacagctttc tttcgaccgc 515941 gacggacagg ctgcctgtgc ctgatacagg gtcgtcagta caagatatag taacccacgc 516001 cacgaattta gctaggtttt tgacaagccg ggaaggaacc gttattaagg aattaatagg 516061 tgcagggcag ttggatgaaa aattggcaga agaatatcgc acgcgatttt tccagcctcg 516121 ccgcctccaa gcgaaaggcc ttctagaaaa gggaattcag aaaggtgaat tgagagagaa 516181 tcttgatatt gaagtaagca tagatctcat ttacggacca attttctatc gtctgcttat 516241 aacaggggat gaggtgaatg attcctatgt gcgtgatttg gtgatgaatg cgtttaaggg 516301 agttcaagct acctctgcta cagagagtat gtagctgata agaactgcaa aagctgcgga 516361 ttatatgaca aattggttcc atcgtacagt gaaatataag atttttgttg ctgagcggaa 516421 tcatcgaggg aaaagttctc ttatcggatg tcgaaaaaga agtcattcaa tcgtgaatac 516481 ataacatcat attattacat tccttttcat cgattggaac aagggttcta tacttcaatg 516541 gaataccgca aagttggagt atttaaacaa caggggaaaa tcgatggcca ttatgtaggt 516601 gtcatggcaa tggaaaaaat acttgcaatg taaacaggcc tctaaagaga cctgtttttt 516661 aatatccaga tgattgtcta gtttcagctt gggctctatg accactccca taactgaaat 516721 agtctaatat ttataccaga agggattgtt tatataaata aaagtttata taatgacggg 516781 ggcgctaagg aaacgcgggg agcgactcag gttttcgttt caaagttttg atccttaaga 516841 tatacggagc gctacatatg gaaacgtaaa ggggaatgta taatcatttg gcgtgtatat 516901 aacgatttgc ttatatattg atttgggaag gaggagctca tatgacgatt gatgttgcgg 516961 cgatgactcg ttgtttgaaa acacttagtg atcaaactag gcttatcatg atgagattat 517021 ttcttgaaca agaatattgt gtctgtcaat tggttgatat gttcgaaatg agccagcccg 517081 ccataagcca gcatttgcgg aaattaaaaa acgcaggttt tgtgaatgag gacagaagag 517141 gccaatggcg ttattattca ataaatggtt cctgtcctga gtttgataca ttgcaattga 517201 tcttacatca aattgatcaa gaggatgaat tgttaaacca tatcaaacaa aagaaaactc 517261 aagcgtgttg ccagtaagga ggcattagat tgacatcaat gattttggca gtattcatct 517321 ttttattaac tctagtattg gtcatatggc agccgaaaaa tttatctata gggtggtcag 517381 cctgtggagg cgcagtttta gctctaatag caggtgttgt caattttcat gatgtgttaa 517441 ctgtgacagg gattgtttgg aatgcgacct tggcttttgt ggccatcata ctgatatcgt 517501 taattcttga taatatcggt ttctttgaat gggcagcgct tcatatggct aaggctgcaa 517561 aaggatacgg tgtgcggatg ttcgtttatg tatctctatt aggagctatc gtcgccgcgt 517621 tatttgcaaa tgacggtgca gctcttatat tgacaccaat cgtattagcg atggtcagag 517681 cattacattt taatgaaaaa ttagtttttc cttttatcat tgccagcgga tttattgcgg 517741 ataccacttc gcttcctttt gtagtaagca atttggtcaa cattgtttca gcggactatt 517801 ttcatattac gtttattgat tatgcatcca gaatggttgt cccgtacctg ttttcgctgc 517861 tggcgagcat cattgtactt taccttttct ttagaaaaag cataccaaaa cgctatgatc 517921 tgactgaggt taaaaaacct gttgaagcaa ttaaagatca aaacatgttc agactgtcat 517981 ggtatatctt agggctgctg ttaattggat attttgcaag tgaatttttt tctatccctg 518041 tatcagtggt agcgggcagc attgcaatca ttttcttaat cgctgcgcaa aagagtccgg 518101 ccgtccatac aaagaaagtg gtgaaagagg cgccatgggc tatcgtattc ttttcaattg 518161 gcatgtacgt tgttgtgtat ggtgtccgaa atgccggatt aacggatgtc ctttcagatg 518221 tgattcaagc cgcagctgat caaggattgt ttgctgggac aattggaatg ggctttattg 518281 cggcgattct ttcttccatt atgaataact tgccgactgt tatgattgac gcattggcca 518341 ttgccggtac agatacacat gggatgatga gagaagcgct tatttatgca aatgtgatcg 518401 gttcagattt agggcctaaa ataacaccga ttggttcctt agcgacatta ttatggcttc 518461 atgttctttc gcacaaaggt atgaagattt cctggggcac gtattttaaa acaggaatta 518521 tcctcacgat acccacttta ttgatcacac ttgtcggcct gtatatttgg ctgctgataa 518581 tccattcttg tttctaaaag gacaaggtca ctatatcaag gaaaacaatg cactggtaac 518641 tcttgccgca gccaaatggc tgaagggtgg gggagaaaat accttggggc taagtggaat 518701 gtgtacagcg caggaatcga agctcaagga tgacatcgag tgctgtcaaa gcaatgaaag 518761 aagcagggat tgatatttca aatcaaacat cggagaaatt tgatgatccg gcaaaagcac 518821 acggaacaga agaagtgttt ccaaagggtc cgtgatgaaa ttggtgaccg tttaaaacag 518881 tttgctgtaa ctggggaata aagaatcgat atattcagcg ttttcttggg ttatataata 518941 caatgtgttg ttcaacaggt gtctgcgagc tgagtgcaga cacctgtttt tgtttttatt 519001 tgtctgagat tcgtaacagg gaagttattt agctggtgac agaggaaaat tgatttgtga 519061 acagaatcat gaaggagacg gtgttttaaa ggagttgtct gttttgcagg aattaacaaa 519121 aaaaaaatac agtagcttaa aaacaatgtt tgatgacaaa tattgtccca catttgtcta 519181 ttcaatatta gaccaaacca ttccgggagc tgtttatgca gatgatcaaa cctttcctaa 519241 atcgtttttt ataggaactg aatcaggcat ttattttatt gcgggagacc aagggaatcg 519301 ggattttcat gatttcattg caggatatta tgaagaacaa gtgaaatcat caaaacgatt 519361 taccttgttt tcttccagtg atacatggga tagcgtactg aaacccatac tgaaagatga 519421 cttaaaccaa atgagaagag ctgcattttc ttatcaacca aaatctttca aaaagacttt 519481 gcaactgcca aaggggcttg tattgaaaag aattgacgaa gacatcattt cacatagcac 519541 agcgtttaac agcgcgtatt atgaggagta ttggaattct gtctcacagt ttgcttcaaa 519601 aggttttgga tttgccgtat tacatggcaa tcacgtagta agtgagtgta cctctatatt 519661 tttagggcat aatcgagcgg aaatggatat ctatacactt gaagaatata gaggactggg 519721 gttagcttat tgcgtagcaa ataggtttat agcgttttgt atggaaaatg ggattgttcc 519781 tagctgggat tgtgatattt gcaacaattc gtccattgca ttagcagcta aactagggtt 519841 taagacggta acggaataca ctatttacta ctctggctaa ccttaatgaa agaaccttaa 519901 aaggagatac caaccgatgt tggtatcttt tttgttttag agttttttta cccttttagc 519961 agaaaaatgg gtgatgaaaa tcttattcat tttatttact tttaggtagg taaaacatac 520021 cccgccaact gtaaccactc cgcctagcag agagagcagt gtgggtatct cgccgatcca 520081 gagccaagat atgatcaagg ctaaagccgg tgtaacataa agtgaaaggg ttgcttctga 520141 agcaccgacg aatgaagtga catatgctag tgcgaagtaa ggaataaccg tcggcaataa 520201 tcctaagtaa acgatagaca aagttgcgct tattgaagcg ttcatcatct cttcgcctaa 520261 gcctggcaga aacacaagca taggtattgt tccgccccaa atggtgaatg taacgaatgg 520321 aataaaacca tattttttta tatagcgggc ttgaaaaacg aaataaatac tctccgaaaa 520381 tgctgccagc aggatgacca agataccgct cattgaatat gtaaagtctc ccgccccaaa 520441 tgcaatcaat aatacaccca ataaactgat catagagcca agccatttcg taaatccaaa 520501 atgctcttta taaaacaggc gggatagcat ggctgagaag atcggtgccg tagtaacgag 520561 taagcttgca actccggcac taactgtttt ttcaccgatg ttcagcaaaa tgtgatagaa 520621 tgcaaatcct aaaaacccta aaagaaaaat ggcaggaatg tctttcaagt cgggtaggcg 520681 catctgagtc aaaacagcaa aaagcaataa tgccatagag ccgattaaca aacgaaataa 520741 agcaaggtgt tctggcgtgt acccttcaag tcctgcgcga attcccggaa aagcagatgc 520801 ccataaacca atcatgagac tatgagatat cattatttga actgttttct ttcgcattcc 520861 tctcactcct ctttacaaaa accaaccagt tatttaatgt gtttctatac taataaagat 520921 ttgatgatat ggcttcaacc agttcaatag attttgaccc aaccaattta ttttaaggag 520981 accgattcta tgagctttcc agaagaaaaa aagatgaaaa agctccctaa gtacagacaa 521041 atcgttcatt ttattaaaga gaaaatagga aatggagagt ggccgattgg aagcaagatt 521101 ccaagccagc gcacgcttgc aaaagatttt caggtaaatc ggagcacagt gattacagcg 521161 ttagaggaat tgatggccga tgggctaata gaaggcacaa tggggaaagg cacagttgtt 521221 atcaacaaca catggacact gatggctaag aattctgctc ccgattggga tcaatatgtc 521281 acctctggca ttcagatgcc aagccgaaaa atcgttcaag agataaatca atcagaatca 521341 aatacagacc ttatacagct cagtaaaggt gaactttcag ctgagatttt tcctttggct 521401 gttatgaaag agatgatggg gaaggtatct caacacatgg aggcattcgg atatgaagaa 521461 ccaaaaggtt acttaccttt gagggaggca ttaagcaact atttaaaaac cattggaatc 521521 aacgtctcat cttcttccat tctgattgtc tcaggagcgt tgcaagcctt gcagctgata 521581 tcaatggggc tgttacaaag aggatcaacc gtttatcttg atcagccctc ctacctttat 521641 tcattacacg tatttcaatc agctggtatg aagctgactg gacttcctat ggataatgaa 521701 ggacttttgc ctgaaaatgt tcatttaaca agaggagagc ggggaagggc tatcttatat 521761 acaaatccat gttttcacaa tccgactggt attcttatgt ctaaaaagcg acgggaagaa 521821 atcctagcag taagtgagaa tacacagctt cctattattg aagatgacat ttatcgtgag 521881 ttatggatcg atgaaattcc gccatatcct attaaaacaa ttgataaaaa tggacacgta 521941 ctgtacatag gaagtttatc gaaaacatta agcccaggtt tgaggattgg atggatcgtc 522001 ggaccggaac cggtgattga acgtttatct gacattaaaa tgcaaacaga ttacggatcc 522061 agttcgctat cccagagagt agcggcagag tggtttactt ccggccacta ccagcagcat 522121 gtagaaaagg ttaggcagca attaaaggtg agaagagaat tggccttgag tgctttagaa 522181 actcatttga aagaagtggc gacatggaat atcccaaaag gagggttttt tgtctggata 522241 aaaatattgc cttccatatc aatgaaatta ctttatacta aagccttatc aaaagggatt 522301 ctgatcaatc tcggcagtat ctatgctcag gaaaaaggga attatattcg cttatcatat 522361 gcttatgcat ctcttgaaga ccttcaaaag gggatttatg agttgggttt aatgattaaa 522421 gaattggcaa gcaggtaact tttatatcct taaatggatg tttcactaaa aaagagatca 522481 agcctaatga tcgcttgatc tgataataac aagggttact agaatagacc aaatcatggt 522541 tcggtcttaa aataatcatg tctctgaacg aaaagtcttt ccgacttctc ttcctaaacc 522601 aaagtagtgt ctgaaattat agataagcgg gctccatttg gaagggttga tatggttttc 522661 gtccagaatg atactttcct cggcatgaaa atgtagtgcc tgcgtctcta caattgcgaa 522721 tgacgattca tattctggaa gccgaatgtg tttcacttcg gcttcgattt ggatagggca 522781 ttctttaatt cgtgttggtg atactgtttt tgattgtaaa ggcgttaacc ctgctgcctc 522841 gtatttttct tttttatatg taaatccgat ctgcttcttt aaaggcggta tactcttttt 522901 tccgctataa gatgaaattc tttcaacgtt ttcccataaa tccgggccag gcaagtttat 522961 gacacactct ttgtgtcttt ccaaattgtc gatggctttt cctcccagtc ctactccaag 523021 gattatataa tgtccaagag cccaagaaga agacatagga ctaatattag tggttccatc 523081 ctcattcaat gtggttagaa gaaatgtcga ggtaccataa tacatgatct tgggtttgat 523141 ttccttaaat cgacgagtgt cttgtttttt gatgtccaac gttttttcct ccttgtcacg 523201 cttacattta tattgtaaag gattaacatt tcaactatca tcgaaatatg aatgtaagga 523261 ggaaaatcat gaatcctaat attgcaaaaa tctcttcgtt gctatcagat ccctcgcgtt 523321 cttccattct tctcagtctg atggatggaa ggatacaccc tgcgggagag cttgcatatc 523381 tcgctaacat taaacctcaa actgcaagtt ttcacctgaa taaattgctt gaagcaaagc 523441 tgattagcgt agagaagcat gggagacatc ggtattacag attggctgac tcagatgctg 523501 caaatgtgat cgaacaattg cttcatattg cgcctaaagc aaaagtcaaa tctttaaaag 523561 agtcaaaaga gaaaaaggac ttgcatttcg cccggacctg ttatgatcat ttggcaggtt 523621 atgtgggcgt gcaaatggca cattcactag ttgagcaggg gatgttaaaa aaagttgatt 523681 taaactttga ggtgacttca gagggtgctt tattcttttc gaagttaggc atcaatgaag 523741 agcaacaacg gaataagagg agagcctttg cccgctgctg tttggattgg agtgaacggc 523801 agcatcatat tgcaggagca ttaggaaacg ccctattggt gcgcatgtta gaagaagaat 523861 ggatcgttcg tatgcctaaa acgagagcga ttaggattac acaaagcggg aaaatcgcgt 523921 ttgaaaagca cctaaacgtg aagatttagg attttgaagc ggaaacatca gatgatgagg 523981 cacgatatct aggaggagta agatttgttc taatcttact ccttcttctt attttgaagc 524041 agctcgattc cccattgcaa tagagatgcg gttccaactg tttatttgat taatgatcag 524101 aacaaggtca acatattgtt cctcatcata atgttcccgc acccgatgat atagctcatc 524161 aggaaccctt ttagatggaa tgagcgtgat gtgttcagat agttcgagag ccgctttctc 524221 ttcaggtgag taaaaatcac attcattcca agcatgtaaa cagtaaattc gctgttcagt 524281 ttctcccatt ttgcgggcat cggacgtatg catatctatg cagaaggcac agccgttcat 524341 ttgagagact ctgattttga ttagttctct cgtcgttcgg ttaattgagg attgtttcgt 524401 gtatttctcc atatccatca tgattttcat accttcaggt gcaatctcat agtaggacac 524461 tctttgactc ataaagcaag actcctttcc atagaatacc tagattgtat cccggtattg 524521 atcattttac caatgtgcgg tttgaatgac agctgtttca gcgtcttttg gaaagaagct 524581 tctttgaata aaaataaggg tagccagcaa tgatgagtgg agctgctaat gcaagcagta 524641 tccatgagcc tgattggctg tctctagtga ctctaatgaa tatataagta ccgatcagaa 524701 aatataataa agcacctaga aaccaataca tgttcattcc tctttttcct tgctttttgg 524761 ttgcgcattt ttgtctgtca tatggcttaa tcgatcaggg ttctgatttt ttaatacctt 524821 ttcggtccgg attccttttc tctttaatga taaaattgtg agatcaatcg atttcaatga 524881 tgatcattcc ttcaatgaat agtaagttcc ttatgatttt aaaggtaaat ttgaaaagat 524941 aaaacgtaca tagaggcaga acgttcatgt acgtttgggc aatgatcact tgttggaaac 525001 tctaatgttt ccctgcacct gatattgttg tgttccttct cttcctataa aatgattgga 525061 tacatgtatg tttgcacgtt gaaatatggg ttcgattttc atgaatctct attcggtgaa 525121 acaggtaaag gaagtggata aggtttgctt ataaggaatc cttttaaaga taaatattac 525181 tcacatgata ggcgggcatt aaacatgctt gcactcagag tgccgggcct ggcttttatt 525241 ctcatgatct atatagcctc tatcgtgctg caatttgttt ctgggggctg gtccatttta 525301 ttgctttatg cgtttaccat attaatcgcc atttttgctt tgcttcattg gcactcatat 525361 cgctgggtta agaaaagagt gattctgtat ttcgcggtac aaggtttgat cacctttgca 525421 cttgctaatc tcatgactgg cttctttata cttgtgatta tcggccttta tgcattttta 525481 attggacaaa ttataggaat ggcagacaga agaaggactt ttctcattct ttatctattg 525541 ctgctgctgg tcataaattc ggcgtatcac cttcataaag gtgaagtttt gcattttatt 525601 gttattgctg cgccgatcat gattgtcatc atcacttatg ccgcaacatt ttttgcccaa 525661 gtcgatgaaa aaataaaagc tcaattgact cttgaaaggc tggagctggc tcatcagcag 525721 gtagaacagc tgacgctgca gaacgaaaga cagcggatgg cccgagactt acacgatacg 525781 cttgctcaag gtcttgtcag tttaaatatg cagctggatg cgattcatgt tcatctcgcc 525841 aaaggcaaca cagagagagc gaaggaaatc atacaacaat cgatgaaaag agtgaaaagc 525901 acaatagctg atgcacgttc agctattgac gatctccgca gcaaatcaga agaaatcggt 525961 gttttaaaag aaagaattac ctcgctaatg gatcatttta tagagtcgac aggcatggct 526021 tgtttattag attacagatt gcatcaggtg ctggatgtgc gtacagctga aaactgttat 526081 tacatcattg gagaatgcat gacgaatgcg gcaaagcatg ctgaggcgaa aacaatctgg 526141 atatccattt gggatgatga aaagggaagg ctccatttaa cagttaagga taacggcaag 526201 ggatttgatg ttgaaaaagg aaagaaaaag agaggacatt atgggcttct tggcatacaa 526261 gaacgcgtca gggcaataaa tggccaattc aatatcaaga gtacaaaatt gaaaggaaca 526321 caaattgaga tcactgtacc aattcaggga gagatgcaag atgaataagg ttttaatcgt 526381 tgatgaccat cttgtcgtga gggaaggtct gaagctttta attgaaacga atgatcaata 526441 caccattata ggagaggcgg aaaatggaaa agtagcagtc cgtcttgcag atgaattaga 526501 accggatatc attctgatgg atttgtatat gccggagatg agcgggttag aggccattaa 526561 acaaataaaa gaaaaacacg atacccccat cattattttg actacatata atgaagatca 526621 cttaatgatc gaagggattg aattaggagc gaaaggatat ctgttaaaag atacgagttc 526681 agaaaccctt tttcacacaa tggatgcagc catcagagga aatgtgctat tgcagcctga 526741 tatccttaaa cgtctgcaag aaatccaatt tgagcggatg aaaaagcagc gcaatgagac 526801 gcagctgaca gaaaaggaag tcattgttct aaaagcaatt gctaaaggtc ttaaaagcaa 526861 agcgattgcc tttgatttgg gcgtctctga gcgaacagta aagtccagat taacgtccat 526921 ttacaataaa ttaggcgcga attcaagaac tgaggcagta acgattgcca tgcaaaaagg 526981 tattctgaca atagacaact aaactgcata tttgaaaatt gcccaaacgt acatgcccga 527041 atgtacgttt ttttcatttc attgtcaact acaatgagaa agaatgtgat caagcaatgt 527101 gttgaaagga gattatcatg tcaaaaatgt tatatacatt aggaggatgg gttgctcgca 527161 atcgcataaa agcaatatgt gcgtggatcg ttgtgttagt tgctgcgata ggccttgcag 527221 tgaccttgaa accaagtttt tctgaggata tgtccatacc tgacacacct tcggaaaaag 527281 cgatggatgt gattcaaaaa gaatttcctc atggtcctga taaagggagc atacgggtta 527341 ttttcggtgc tggtgatggg gagaaactta ctgggaagcc agcaaaaaaa gcaatagaag 527401 atacgttcaa agaaatcagt aaagatgatt ctgttgactc gattgcaagt ccttttgtga 527461 cagggacaat cgcgaaagat ggcacagttg cctatgctga tatccagtat aaatcatcag 527521 cagatgatat aaaggattac tctatcaaac acttaaaaga cagtttgaaa atggctgatg 527581 atgaaggatt gcaaactgag ctaagcggag atgtaccggg agcggagatg gagataggcg 527641 gtgtctctga aattgtcggc attatcttgg cttttgtcgt tttagccatt acattcggtt 527701 ctttattaat agcaggtttg ccgattttaa ctgcactgat tggtttaggt gtaagtattg 527761 gactggtttt gattgggaca caagtatttg atattgcttc tgtcagtctt tcattagccg 527821 gaatgattgg ccttgctgtt ggtattgatt atgctttatt tatttttacg aaacaccgcc 527881 agtttttagg cgaaggcata caaaagaatg aatcaattgc gagagccgtg ggaacagcgg 527941 gaagtgcagt ggtttttgcc ggacttactg ttatcgttgc actttgcgga ttaactgtcg 528001 ttaacattcc ttttatgtct gcgatggggc tgacagcagg gcttagtgta ctgatggctg 528061 ttttggcttc catcacactt gtgcctgcgg tcttatcgat tgcagggaag cggatgattc 528121 cgaaatcaaa caagaaaata gaaaaacaaa gcactgaaac aaatgtctgg ggacgctttg 528181 tcaccaaaaa tcctatcatg ctaagtgtat gcagcattct gattttgatc gtcattagta 528241 tcccatctat gcatttggaa ctgggcttgc ctgatgctgg gatgaaagct aaggataatc 528301 cggatcgccg ggcatatgac ttgcttgccg aaggctttgg agaaggattt aatggccaat 528361 taacaatcgt agcggatgcc acaaatgcta cagaaaataa ggcggaggct ttcgcagatg 528421 cagtgaaaga aataaagggc ttagaccatg tagcaagtgt cactcctgca atgcctaata 528481 aagaagggaa ctttgccatc attacggtcg ttcctgaaac aggtccaaat gatgtcacaa 528541 cgaaagattt ggtacatgat gtacgcagtt tatcagataa aaacggagta gatttgcttg 528601 ttactggatc aactgcagtg aatattgaca tttcagatcg cctgaatgat gcgataccgg 528661 tgtttgctgt acttattgtt ggctttgcgt ttgtattgct gaccatcgtt ttccgttcgc 528721 tgcttgtgcc gcttgttgct gttgcaggtt tcatgttgac gatgacagcc actcttggaa 528781 tctgtgtatt tgtcttgcaa gacgggaatc tcatcgactt tttcaaaata cctgaaaaag 528841 ggccgatact cgcgttcctg ccgattttat cgattgggat tctgttcggg ttagccatgg 528901 attatcaagt attccttgtc agcagaatgc gtgaagaata tgtaaaaaca aacaatccag 528961 tacaagccat tcaggctgga ttaaaacaca gtggtcctgt tgttacagca gccggcttga 529021 tcatgatctt cgtttttgca ggatttatct ttgcaggcga agcttctatt aaagccaatg 529081 ggctggctct ttcctttggt gtactctttg atgcctttat tgtaagaatg acactgattc 529141 caagtgtcat gaagctgatg gggaatgcag cctggtattt gccgaaatgg ttagacaaga 529201 ttattccgaa tgtggatata gaagggcatc aactgacaaa ggaaatacag ccggaaatag 529261 atcatgaaca aaagaaacaa atcagtgtgt aatagaaaaa gcagatcttt tatgatctgc 529321 tcttttgctt atggtagtat ttagaagatg aagtcggcag ttaaaaggag acgcttatgg 529381 cgccatcact cattttcgat atggatggaa ctttgtttca tattggcaga agctgcatca 529441 tactagcagg catcccagga gaagtgacat gattttttga ctttgcattc actacttgat 529501 gccaaggatc ttgagaatcc ttcttgaaaa taaaggattt tacaactgat catataagaa 529561 acctaaagaa acaagcacac aaaaccagct gcgggttttg tccaagaaaa atagagtcca 529621 taagagggac tctatttttt gaagtgcccg gctagaagca tattgcagga ctttatgaat 529681 gcaaatcact atcttataag cccttaccgt gaaatgcctg tttctgcatt gaaaaaacgc 529741 attacacgtt catttacgta agtgggttgt tccatcgata aaacatgtcc ggcattttta 529801 atgacttccg cctcaatatc tggaacgaat gaagaggctc ggtgcagggc tgagtgggga 529861 tcatagatga cttcatgttc accaagtaat aataggatag gaactcttgc tgaacgtaat 529921 tcctcatcgg taaaaacata cggaaatccg tcggcattag gatttggatt tcttgatcca 529981 tcctgccaca ttacccctgc cttaaactgc ttcacaaaaa tcgggtgcag cacattctga 530041 tcattcatca tccaatttaa gaatgtttca actccatttg acgctgtaag gccaagagcg 530101 tatttgtaga aatcgtgatg aaatggcaaa aacgtttctg ccggactcag tatagctgcg 530161 ctttttactc tctcaggcat acgtaaaagg aaattcatcg tatggagacc gccaagcgaa 530221 agtccgatca tgtgggactt ttcgatcccc agattgtcaa acacatcaag aagccaattg 530281 gcgtaatccg ttcttgtacc gcttacattc tcaggaatac tcttgttttt atcacctatg 530341 atatcaactg cataagttct gtatttactg ctccaatcgg cgatgttggg ataccacatc 530401 gtcgagctga ataatgctcc gtggagtaat acaagcggcg gggcatcctc tgggccgctt 530461 gcaatcacat gtgtttgacc aaaacgagta gatatataga atgatttaca acggaccggc 530521 caaagactaa ggctttcatt ataagtttga taatagcgga taccgttgtc acttaattcg 530581 ggaatactag atgaatggtt tgacatacaa atgcccctcc caattttgtt taaatgaatg 530641 tgccgtttcg tgatggggaa tctgattttg atataacaga ctttatttac aatataatac 530701 agttgttatt agacgtcaaa tccaagatga aaaggaaaaa aacgattgaa acagattatt 530761 gaaaatcaat ataacagaat attaacctcc tttgtggagc cgcttcatta aaaccgcaat 530821 ccaaatgcat gaatcacaaa aatcacaaca ggagggatca ggagggaagg cagcagattc 530881 agtgttttga acttcttgat tccaagaatg cttagacctg aactgaggat gagtatgcct 530941 cccacaattg tgatttcatt aataaggtct gtattgattg cgctctccat tacttgtgca 531001 aataaataga tggagccctg ccaggaaaat aatacaagtg cggcagccgc tattccaaaa 531061 ccaaaagttg aagcgagcac aatggaggtg atcccatcta acatcccgtt tgtcagaagg 531121 tatgtataat ctccatgcaa agcggcttca acagggccta atattgacag cgaacctata 531181 caaaataata agaccgcagt tgataagccc tctgctaaat tgcttttaga aaatttgttc 531241 accagcttgt tgaatcgtaa ttctaaattg atgatctggc ctagcaaacc tccaatggct 531301 aaactcacga tgaatagaat ggggtattta ctatcaggca aatgctgtgt aatggcgttg 531361 atccccagtg cgaccgcagc gaatcccatt gcctgcatca aaatatcctg gtattcatct 531421 ttaatgcctt ttttgaatat ccccccgatt atgcttcctg caatgatcat cactgtgtta 531481 aaaatcgttc caaacataag ctttctcctc caaaaatcat tcctgcataa aaaataaacc 531541 ctctagttag tagagagtca agggagatca aaacatattc atgagattat ttgatgggca 531601 gcaggatttc agtcacgtaa ttatctaggt tattcgtaat gccataatca atgagtgtga 531661 tttcgattga gtcccctgct acctcataat gatgttcttt catatatgcc agtaattttt 531721 tgtagtatgg ttcggcttct ggatgtgacc ctttaaacct aatttgcaga tattctcttg 531781 aaggaaagat gatttctgaa gaagtttttt cattttcatc ttcaagaatc ataaatatac 531841 tggaatattt gtcaaactgt tttgctttca catttgctgc agaaatggat aaaccaatct 531901 tgcctatgaa tatatcttcg tttacattca ggtgggttct caattcagct aacgaatgtt 531961 cgatatcatg gccgagaaca tattcatgct gcaaataggc cacacgcatt gcgggaagtt 532021 tgatttttga aatttgatgt aacggcatgt taacggcatc ttctatatgt gtgatgcgtc 532081 gggagatctt tcgttcaatg cgttccaatt ctttcttctt gcgatcaatt tcaacctgct 532141 ggctttttag taaatgaaga agagtgtttg tattttgaga gttataaaaa tcaagaagct 532201 tattgattgg caggcctagg gccctcaaat acttgatggt atccagccgc tcaaactgtt 532261 gggtagaata atatctatag ttcgtttgct catctttata ttccggtttc aaaaggccga 532321 tttcatcata ataccgaaga gcagagattt tcacattgaa taactttgac acttctccaa 532381 tcgaaaaaaa ttccttcatt ctaacaacct ttctgtccta tgattgatat acacacatta 532441 tatagtacgg cgagtactaa aggtaaagtt tgcagcataa agaaaaaact ccttctaaaa 532501 aggagctttt cattcttcga aataaggatt tacatggatg agcacttctt ctacatctga 532561 aaactgtctt ttgatttcat ttcgaatttc gcgggcaatg tcgtgtccct gcttaattgt 532621 caaatcatga tccaaagata aacggacatc aagcaattta tagtggccat gttctcgcgc 532681 gcggattcta tcaattcgtt ttacctgatc acattgaaaa ataacagctt tatattcctc 532741 tatcagctcg ggatcaacac tcttttccat gagcacatca acagacggcc tgattaattc 532801 cattgaaatc ttaaaaatga ggtaagcaac gattgcactg gcaatggcat cggcgtacaa 532861 cagataggac catccacggc tgtttccgat gatagccaac aggacgccga taaaagcggc 532921 aagagaggca acgatatcgc ctttatgatc gtacgcaatc gctataatcg ctttgctgtt 532981 ccattttttc ccttgcttta tagaataacg atataagatt tccttagcca cgtacgaaat 533041 cagagccgca aacaatgcgc tgtattgggg aacgcttggc cctttaacaa aggacagaat 533101 cgcttctatg aggatataaa cggatacgat cactaagata attcctacaa tcgcctcact 533161 aatgacttca gcttttccgt gaccaaaagg atggtcttga tcgggcggtt tattggaaat 533221 tccgatcact gccaagactg caatcgaagc aacgacatct gccgcggaat gtattccgtc 533281 tgcaaacacg gcttcactat cgcctaccag cccaaaaaag acctttcctg ccattaagat 533341 cagattggcg atcaatgcaa tcaaagcaac ttttctgctt atttgttctc tttcacttgc 533401 cattttttcc tcctataaaa ctgcacaaaa aaataggagt gctctatata cgctctccgt 533461 atcctttcct gtgtaatcac tttgtttatc ataccaattc aatttcgagt gggtctatag 533521 caacgttgtt tcctgtttac taataaataa ggtgacagaa aaaaagttgg agctatgcta 533581 aaaaggtcat acagcaaaca aatgagttct tatgtaacaa cagtgatgat tcgctattaa 533641 aatgctgccg tcagtgaaaa atttccacct aattttcaaa aacctattga catgagaaga 533701 tctgtatttt actattatct catattcaag atattttaat ttgagatatt tggtcggaaa 533761 gatcagcgat caagcgcaac tctaagtgtt caatcgttgt cagttctttt acacaatatt 533821 caatatgatt ttttataaca taatatctcg aattcgagat aaaagggagt gtagcgtaat 533881 ggctgaattt actcatttag tcaatgaaag acgatctgca agcaattttc tttcaggtca 533941 tccaatcaca aaagaagatc tcaatgagat gtttgaattg gttgcattgg caccatcggc 534001 ttttaatttg cagcatacaa aatatgtgac ggttcttgac caggacgtaa aggaaaagct 534061 gaagcaggcc gcaaacggac aatataaagt ggttagctct tctgcggttc tcttggtatt 534121 aggggataag caggcatatc aacaagcggc cgatatctat gaaggtttaa aggtattggg 534181 gatattaaat aagcaagagt atgaccacat ggtgcaagac accgtttcgt tttatgaaaa 534241 caggggagaa caatttaaga gagatgaggc gataaggaat gcttcacttt ctgcgatgat 534301 gtttatgctg agtgctaagg aaaaaggctg ggatacctgc ccgatgatcg gctttgatgc 534361 ggaagccgta aaacggattt tgaacataga cgaccaattt gaggttgtca tgatgattac 534421 gattggaaaa gaaaaaacag agagcagaag accgcgcggc taccggaagc ctgtgaatga 534481 gtttgttgag tatatgtaaa aggagcggat aaaaatggct aaaaaaacga tgggaattca 534541 tcatattaca gcgattgtcg gtcaccctca agagaacaca gatttttacg caggagtgct 534601 tgggcttcgt ttggtcaagc aaactgtcaa ttttgatgac ccaggtacgt atcatcttta 534661 ttttgggaat gaaggcggga agccgggaac aatcattacc ttctttccgt gggccggagc 534721 ccgccaaggc gtcattggag acggtcaagt tggcgtgact tcgtatgtcg tgccgaaagg 534781 ggctatggca ttttgggaaa agagactaga aaagttcaac gttccctaca ccaaaatcga 534841 gcgctttggg gaacaatatg tagaatttga tgatcctcat ggactgcact tagaaatcgt 534901 ggaaagagaa gaaggagagg ctaatacgtg gactttcgga gaagtaacgc ccgatgttgc 534961 cattaaaggt tttgggggtg caaccctatt atcagagcag cctgacaaaa ccgctgacct 535021 tttagaaaac atcatggggc tggagcgagt cggcaaagaa ggagacttcg ttcgttatcg 535081 ttccgccggt gatatcggaa atgtgattga ccttaagtta acgcctattg gccgcgggca 535141 aatgggggcc ggaacggtgc atcacatcgc ttggcgggct aacgatgatg aagatcagtt 535201 agattggcaa agatatattg cttcccacgg atatggtgta actcctgttc gggatagaaa 535261 ctactttaat gccatttact tcagggaaca cggggaaatc ctgtttgaaa tcgcaactga 535321 tcccccaggc tttgcacatg atgaaacaca ggaaacaatg ggcgaaaaac tgatgctgcc 535381 tgtgcaatat gaaccgcatc gcacacaaat tgaacaaggg ctgctgccgt ttgaagtaag 535441 agagttagat tgatttgaca cataaaaaat aaagaaacat atattcaatt gatgattgct 535501 ggatggtact gtcagcaaag aatcagataa aatcaaagat gaggagagat acaaatggaa 535561 gatgcaggac tgttgcttat tcgtataatg attggtgtgg tgtttttgtt ttatggcaca 535621 caaaaattat tcggctggtt tggcggatac gggattaaag gaaccggaca atggttcgaa 535681 tcaattgggg tgaaaccagg aaacgttgcg gccgctctat caggtcttgg ggagttagta 535741 agcggaattc tatttatttt aggcgtattc ctcccgcttg gagctgctat cataacaatc 535801 atcatgttag gtgctatcgt aaaagtccat ggagcgaaag gttttgcgaa tggcgccgga 535861 ggttttgaat ataacctggt gctcattgca gtttccatag gggttgcact catcggttca 535921 ggagcttacg ctttgcattt ttaatacgaa agtatgtaag aacagttgct gcttgtcagt 535981 aactgttctt ttattttcac attttcggca agcttgcagg tactctgcaa agcaaaaaag 536041 cggatatcat aaatataaat ctgtatagtg aatgatacgt attgatgagc ttggtcatga 536101 aaaacagacc tatttgaagg agtaaatgga tgaaagagat gacaggatta cattcattag 536161 tttctataga aaactttatc aaacagcaca aattcagttt tatttatata tcaaggcctg 536221 gctgtacagt atgtcacgca gttctgcccc agctcagaat agtattggat cagtttccaa 536281 acatcaaatt ggggcatatc aatgctgacg atgtagcaga ggtcgccggc agattttcag 536341 ttttcaccgt tcctgtgctt cttttgttca ttgatgggac tgagtttcta agagaagccc 536401 gttttgttca ttttgaacag cttgaacaaa agctgaaaag ggtttatcga ttatatgaag 536461 gcgaataaag gaataaggca aaaaaagaac tcaaatgagt tcttttttta ttcttcacta 536521 ggcgaagaag ggttatcaac ctgcccttga tcacttgtat cattatcaca acttgctgaa 536581 ataataattg aatgagaagg agagtaatct cctaatgtga aattcactcc gtaatttttg 536641 ctgttcgcag tatggctgtt ttgcaagttt tgtccgatat ctgtattggc gttttgtgtc 536701 attccattta tcgtgagatt tgagatgttg atttgagatc gcatgcttca aaaactcctt 536761 tcactcagaa gtagctgtca taaaggacgc tggcagtcta tttacttcta tgatattgcg 536821 tttttatatc attgcatcaa cataatggta aaaataatag cgagtgaatg atcatctttt 536881 gaagatgatc aacctatcag cagaaataaa gccgcctgat aaagaggcgg cagatcgtta 536941 tatgtcatct atgaatttga tgtatcgttt ttcgtttgcc tgaaggataa gatagtcgtt 537001 tttaatgatg agtaggagcc tatagcagcg tagccataaa accagcccat aaatacgcca 537061 gaaaagaggc tgtgtcgatg gcttatgaaa acagaaatga caaggcctgt tattaaggca 537121 actgacggta caaaagtttt ggggattttc aataatattt tgaggatttg ggttatcaat 537181 atgatgattg gaacagctat cacagcatcc caaaagttcg tgtgaataat tggaaaagcc 537241 atacggcacc tcatgaagtg tttatttctt aatttttacg ctaaaagctt ggaaagcagc 537301 tcttggatcg catatgttac attttgggct tgattggcgg agcttgtttg gcttaaagca 537361 ttggattcaa aaaccaaacc tgtattactc ccaccggaac cctctgttgt tttagacaca 537421 gagaacgggc tgatggaaac tgcaaatccg ttattaaaaa cgctgttccc ggatatcgaa 537481 tgaatataaa ctgggaattt catcattcat ctctcctctc tgttatgact gtttatacaa 537541 tatggtgtgt gagcagcagt tgcttaaaca aaacggcaaa aactttcagt aagagacaaa 537601 aacctgcaaa atgccacaag cgccttttgt taatgcagct ttttagggac gtttttttta 537661 ttttttttgc caacttcatc aaaaatattc tgattgccag actgggcttg tccgtcctta 537721 tttatgaaat cggggtgaat gagttttttc agatccctga ctgttaaagg cttggcgtca 537781 tcagttaatt ctattcctaa ttgcccgttt gcctctaatg tcgcaatttt gacatcttgt 537841 atagccgtaa cgccgtgaag ccttagctgc atttcaagct ggtcagctgt aagtctcatc 537901 ttctttaagt tttcgatatg aagctgtccg ttttcaatga cgatttttgc ttttccggtt 537961 aacatctttt caatggtgtt cgatttcatt tggatccatt ccataacgat gagtgtgctt 538021 gtgaaaattg ccgctgcaat taatgttttg aagaggctgt actcgatgat tggctgaacg 538081 ataatagttc cgatcgaaat catgacaacc gtttgagtcg acgtcatttg tgcgattgat 538141 ttccttcctg aaattctcag caaaatgacc ccggctacaa tgagaacaag agattcccaa 538201 gtgaaattca tgctaccacc tgaccaatga tgaattagat ttgtcatggg attggctttt 538261 cttccggcca atcgcaattt aatatatccg aaaggcagtc ggttcattct gtcctgaacc 538321 gaacaatatt tttggtatag atggatatat taagccaaac aatgatagca acaggagttt 538381 tttggccgaa acaatctggg aagcggggag cgccataaca tgattgaact tgaagttgtc 538441 attagaacgg ttgccagctt tggcttgctg ttaatcgcag aacgaatttt aggcaaacag 538501 acaatctctc aaatgacgat ttttgatttt attgcggcga tcacactagg ggcgattgct 538561 gccggattag cttacaatac ttcaataaaa ccgcacaata tggccatttc gtttagtatt 538621 tttgtgctaa ccatttttct aatttcgttt ctgtcgataa agaacaggaa gctgaggaaa 538681 ttttttgccg gagatccaac agtgctgatt caaaacggga agatacttga atcaaatatg 538741 aggaaaatgc gttacacact tgattattta aatcagcaat tacgggaaaa agaaatattt 538801 aatatcgaag aagttctttt tgccattctt gaaacgaatg gtcagctgac tgtgttaaga 538861 aaaccgcaat tccggcatgt gaccaaacag gatttaatga ttgcggtaaa ccaagaacaa 538921 aggcttccga tagaacttat tatggacgga gaaatcattg agaataattt aaagcagaat 538981 cgtttgacgg aatcctggct tttggaagaa ttgcgaaaaa gagacataaa ggtgaaagag 539041 accgtgtacg cagtgctgct gggtaatggg gatatttatg tggatcaata taaagaccat 539101 atatcagtcc ctatggataa ggaatgaagg aacaatcaat cttaaagccc cttattgaac 539161 gcaacggttt caacttgtct tgggtacgaa atatgcagaa gcccgtttaa cagctgaatc 539221 tgtaacaaat gagtttcagc ggcttcggga agctgaatga ttcgctcaat ttctccgtaa 539281 taccgttcac gcagcacttc catttcggct ggaaaaacag gcgtgatcgt tcctttgatc 539341 agcagctggg ttttagacag taaacggatc gttaattctt cctcatacac accgggcatt 539401 tccacaatga taaaattata ttcctcatct tgataaaagt cgtaaacaaa cgtagaagct 539461 tcggaatcaa aaaaatgttc cggggcttta tatttgagca catttgtcca aaagtcactt 539521 tgtttatatt cattcgtaat ctcaagccac tttcgaattt tttcgaaatc catatgagat 539581 tctccttaaa tttgatttga aatcggcgca gaagggtttc cgatttggtc ttggtcacta 539641 acgtctgaat caatatttcc agtgtttaaa agtgaagacg taggcgaaag atcccctaag 539701 gaaaagtttg ctccaaaata tttgctgttc gcagtatggc tgttgtgcac agtcggaccg 539761 acatctatat ttccgttttg cgtgacgccg ttgatcttaa tatttgcgat attaatttga 539821 tatggcatag acgaaacccc tttaatctaa aattggcggt ggtgcaatcg gaggagcatt 539881 aacgttggat gtatcagagt tgccgataga tgtctggtca tttacatcag gatcgtttaa 539941 gaagttttcc attacggatt ctgtaggtga tgtatcaccg aaagaagagt tggtcccttg 540001 agatttttga ttgttggtag ggctgttata agcagcttcg cctattgtaa ttgaaccatt 540061 gcccgaaata ctgttgatct tcaaataata taggttgatt actgtagacg gcatcccatc 540121 acacccttcc atctttctgt acagtacatt atgcgccgct gcacccaatt gttccttgca 540181 tttacgggca aaactctatc tggccccgga gtgatgctca attatcagtg aatgaaaagc 540241 cattgatata ggaatcaatg aattgattca gttattcgaa atgcatgaga ccttttaata 540301 aaggaagctg gcaaacagga tcagtttgaa ataattgaca atgaagctaa tgccatgaaa 540361 taatactcgt gagtaacatt actcgtgggt attatttttg gggtggtcct agttgaaaag 540421 taaaggagta gaaagccgaa aacgattact taaagctgcc gctaatgaat tttcggttcg 540481 gggattccat gacgcgaagg taagtgaaat tgtgaaaaaa gctgggttca cgcagccttc 540541 attttacctg tactttcaaa gcaaagaagc catctttgcc gagttaataa ccgattttca 540601 ctctcgagtc agaaagctga cagagtcact tcttctggaa aacggattaa acacggagga 540661 tgtgtcaaaa cgggtactgc tagctgtaga gactgttttt caatttttgg atgaggacaa 540721 ggatttaacc aagatcggct tttttctcaa cccggaagca aaacaaatga aaaaagactt 540781 ggcgatggtt ttgaaagaga acttagaagc agaacagcgg cttggctatt ttcactctga 540841 actggatatg gaaactgtcg ctgagtgttt ggtcggcatg attgaacatt taaccgaatc 540901 atttttgtta accggaatca aagatccggc aagcctcgca gcagaggttg tgaatctttt 540961 aatttacggg atgcttccga aagggaatga tgtaagatga tatctattat gatgaaagtc 541021 agtttggcag tttttatgct tgcgggaggc atcataaagg taagccgcgt tccctttcaa 541081 gttgagcatt ggcggcatta tcaatatcca ttatggtttc tgactgttac tggcattctt 541141 gaaatagccg gggcacttgc tatgacagcg ggaatttgga atcggtatgc agcaattgga 541201 gcaggtgttc tgtttgtcgt tctcatggcg ggagcaattc atgcgcatat gtttcgagca 541261 agacaatctg tcatcatggc gatacaagcg atgatttgtt tgattgtttc aatcatgatc 541321 atcatgggga gttacacgta agcttttcac taatgtttaa gaacaagccc atttgcagga 541381 aatctccttt tcttatcgaa taatagaaag tccaggaatt aactgaatca gtaaaataga 541441 gctccatttc tgtgttattc gtccggcatc agctgggctt tttttataaa ggaggaatac 541501 aggatggcat tcactttgga agacatgact gaggaagagt tcgaagcctt tcgcgggatg 541561 tccgtgcaaa attttgcgaa acaaaacata acgtcaggaa cttggacgga aaaagaggca 541621 tttgagaaat cggagcaggc atatgagaac atgattccga atgggcgaga cagcagcaat 541681 cattattttt ggaacatcac aaatgaccaa ggagaaagaa tgggctggct ctggctgtat 541741 gctgatccat tacatccgca aaaggaagcg tttatctatt cctttggatt gtatgaagcc 541801 tttcgcggaa aaggacttgc tcaattggcg cttcaaacgc ttgatgaaag agcaagagag 541861 cttggtgcgg aaaggctggc tctacatgta tttgcacaca acgagacagc cgtctatctt 541921 tatcagaaga tgggctatgc catgaccaat atacgtatgc ggaaacagct atgctgaaaa 541981 gccgcttacg ttacccaaat acaacatgcc tatctggaag cggtggcagg gtactataag 542041 tcatcattag aaagattaag gtcatgggag gcttgaacat ataaagaaaa aggacaacag 542101 ctgttgtcct tttcaatgcc gcttgaactt tctccctcag tcttttttgt cttgatgatc 542161 cagctctttt attcgtttcg taagctcatt gaaagcctga tcaagctcct tatacccttt 542221 atcatttggc gtcataaaac tgagctttcc cagcacttct tgtctttctg tctcaagctt 542281 taaccgaagc tcctcccgct catttctttc tgaaggaacg tcgtttaact gcttttcgat 542341 gccgttgttt gagatgacga gtttactgtt tgttgttttt tcgagaaagt atcggtcatg 542401 tgaaaccgcc agcaatgtgc cgctgtattg tgacagtgtt tcttccagct gttcgcgtga 542461 cggcaggtcg agatggtttg tcggctcatc taaaatcagc acgtcttttt cctccagaat 542521 atatgccatc agcttgatct ttacacgctc acccatactc atatgcttga tcggttcagt 542581 ccattgggcg gctgtaaaac ctaagtgcct catcagattt tgaacgtgcc cccttgcttt 542641 gaatgtttca ttctcaaata actcttccgg tgtttgttct aaaggcaaat caaacacctc 542701 ctgcgttaaa tagccgatgt ttgcggacgg cgacacccat acacttcctt ctgctgtttc 542761 ctgtcccaga atgatgttca gtaatgtcgt ttttccgctg ccattggggc ctatgatcgc 542821 aaccttttcg ccgtgctgaa ttgtaaagtt tgcgttttta aagagagtcc tttctccaaa 542881 cgcttttgtt acattctgaa cttctaaaaa acgttttcct gttttgtggg ttgtatcgat 542941 tgaaaagcgg actgtatatt ctggggtaac gggttccgcc tttgcttttt caagctcttt 543001 ttcaagccgc ttctgcttgg attttatctg ggcatccgta cgcttcgctt ttacccggtg 543061 atattcttta aacccttcct ttttcgtcga ttgagcatgg gctttttccg accaagaagc 543121 gagcccattc atttgtgctt caatccgttc aaccattttt tgctgctttt catattcacg 543181 ctgctgggtg agtcttttct tctcccggaa cttcatatac ccggagtaat tccctttgaa 543241 ttcaatcagc gtctgatcct caagcgacca tatttttgtt gcggcttcgt ctaaaaaata 543301 tcgatcgtga gaaacgagaa tcacagtgcc gttataatgt ttcagctgtt ggatgagaaa 543361 ttgcaagctt ttttcatcaa ggtggtttgt cggttcatct aacagcagca gatctgcatc 543421 ctctgatagt cctttcgcca gccgcgcttt cagtttttca ccgccgctta actgatgaaa 543481 atcacgaaga ggcacatgcc atttctccag taacttcttt tcggcaggtg tctgatccgc 543541 aaaggaatac gccgcggttt cctgttcaac caaagccagt tttatatcct tccgaaggat 543601 ttgaccctgt gcaggggcta agtcattgtg aatgaggtgc agcaacgtag atttcccagc 543661 gccgtttttg ccgataatcc caatgatatc tccttgctga acactggcgt ttacatgttt 543721 aaaaacagtt tgatccttta cttcatagct aacgtttgtt aatgttacga tctctttcat 543781 ccatatccct cgctttaaag ggagaataaa aaaatcctcc caaatgtgtt ggaaggatta 543841 gccgtgcctg tgcatgatca aataagctat tttttataaa tagcagtgtc gtatatatag 543901 aaaatgggca gactaatcct attttttgat ttgaaatatt gatttcaaac ggtaaaaata 543961 agattagtta atcattgtcc acccatcatc ccttcttgtt ttgattacaa acactatagc 544021 atacctttaa attcaaaagc aaaggtcatt ttcatcaaaa aaactcctgc tctcattttt 544081 gaggcaggag ttttgagtct tattgatgct tcgcttttct cactttataa atcacaatca 544141 gcaaaataaa ccaaaccggt gtgacaaata aggaaacacg agtatcctgt gccagtgcca 544201 gcacaaccag aacaaacgcc aggaacgcaa gaatcaggta atttgtaaac ggataaagcg 544261 gaagcttaaa cttgtttgtt ttcgctaatt caggtcttgt tttgcggtat ttcatatggc 544321 agatgaccgt aatcccccaa atgtagataa agcatacggt tgaaatactt gtgatcaggg 544381 tgaatacgcc ttctggcatg atgtagttta acgtaacacc gattaaaatc acgatagctg 544441 aaaagaataa agcatttcta ggcactttac gctgagtcag tttcgccatt gactcaggcg 544501 cattgtgatc tttcgccagg gaatagacca tacggcttgt actgaataca gcgctgttgc 544561 atgctgaagc agcggatgtc aacacaacaa agttgataat acttgcagcc ccgacgatgc 544621 caacagcgac aaatacttgt acgaatgggc tttcgctggg attgatgata tcccaaggat 544681 agatgctcat aatcacgaga agagccccga tataaaaaag cagcacacgg acaggaatat 544741 tgttgatcgc cttagggatt actttttcag ggttttctgt ttcaccggcc gtaagcccga 544801 caagctcaat gccgacaaaa gcaaacacaa ccatctggaa cgagaggata aacccgtgca 544861 tgccattcgg gaacaggcct ccgtggctcc agaggtttgt gaagctggac actcctgagc 544921 ttgtggaaaa gcctttgaaa atcatcacaa ggccaatgac gattaacgcc aaaatggcaa 544981 tgactttaat caaagcgaac caaaattcta attctccaaa aagcttgact gtcgccagat 545041 tcataatcag taaaataata agagcgatta agccaggcac ccattgcggc acacccggga 545101 gccaatattg agtgtagagc ccgactgctg tcagatcagc catcgcaatg gaaatccagc 545161 agaaccaata tgtccagccg gtgataaaag ctgccatatc gcctaggtag tcttgtacaa 545221 aatccacaaa agagtgatag ttcaagtttg ataacagcag ttcacccagc gatctcataa 545281 ttaaaaagca aatgatccct gtgatcatat aagcaaataa aatcgaaggt ccggcaaaat 545341 gaatcgattt gcccgagccg agaaataagc ctgtcccaat ggctccgccg atggcgatga 545401 gctggatatg cctgtttttc aagcctctct gcaacgtttg ctgatttata ttgtctttcg 545461 tcatgtcgtc tgtcacttta tgtgttcctc cattgaaaat tgtttattga gtcagcaatc 545521 tatttttaat gattattata acactaaaat ttctatcttt tttactaaaa aaggattgat 545581 gaaaagaatt ttaatgtgat ttggactatt tcccgaaaaa agcggctcca tttagggagc 545641 cgctttttta tgctttttca gtttttgtca taaacaggta gagcccgtaa tctgtcggtg 545701 cggatgcgta gcctgcctgc cgcagcattg ctgtgatatt gccgcggtgg tatgtcccgt 545761 gattgacaac gtggggaagc agttcggaaa cagttgtttt catgattccg cttgagggat 545821 tttgaatctg gagtggctta ttgagctgtt ctttttgctg taaaaatagt atatagcgct 545881 cggataacct cagaaaaagg tcttccattt cctctatttc tttagcctct gtctgttctt 545941 taagctgttc agctaaagcc aacgcatcgc tcaaggtttt gccggaaaac acttcaatcc 546001 agccgagatc agaaagataa acatgagaca atacatggga tattgacgga aacacgcttt 546061 gaatttcttg atggtatatc tcttttggaa gctcttttaa tcggttgaat atttgttgat 546121 tggcccagac gttatattca tacaatttga atgcaaaatc tgacatgtta aaattccccc 546181 tttcgtgtgt atagctttca ttatacacga acatgagttc ttatgtagag tgctcgaaaa 546241 taaaatttgt tgacatatat agtttagagg aataaactaa ttgacattga acataaagtt 546301 tagcggggta aactataatg cgtctgatta gagctcattt cataaattct tgttttttgc 546361 agcacacctg tcgactcaag aagcaggtta tccagcaggt cagtaattaa gtttccgtgg 546421 ttatacaccc acgacccgtt ccacggattg ccccctgcat caacaggaag ggaactttgc 546481 gctccaataa tataatgatg aggattagca tgtttaaccg cttcatcaag tggcgcttga 546541 tctgtacctt gactgccgac accttcaccg cctgattcat ctaataaagc attgattgtg 546601 ttttgaacca gttcaacgtg ggcaatctcc tctaaaaaaa tgccgcgaag cagatcgcgg 546661 tactgtttct gctttcctct gaaattagag ctttggaaaa aaactgcatc attgtacgca 546721 tttctccgta atgaccgcct aatatctcct gcaggacctt agcagctgcc gggtctggct 546781 tgtccggttt aatgatatta atcagttcct ctttgtagta atacataaca cgcctcattt 546841 cttcttaaga gattttctta tattatttgt aagatgagat aaaatatata catgataagc 546901 atgggaaggc gtgaaagaag aaaataaaaa aatacaggaa aagtgttgac caaataaaac 546961 aggcatggta tattattaaa cgtcgctgat gaacagcgtg aaacaaaaca gaaaaacaaa 547021 aaagttttcc taaggtgttt acaagatttt aaaaatgtgt ataataagaa aagtcgaatt 547081 gaaaaagatt cgaaaaaaca ttaaaaaact tcttgacttc aacatcaaat gatagtatga 547141 tagttaagtc gctcaataag cgcccgtagc tcaattggat agagcgtttg actacggatc 547201 aaaaggttag gggttcgact cctctcgggc gcgccatata agataccacg cgggtgtagt 547261 ttagtggtaa aacctcagcc ttccaagctg atgtcgtgag ttcgattctc atcacccgct 547321 ccattattga atgatctttg aaaactaaac aagacaaaac gtacctgtta attcagtttt 547381 tgaaaatcgc acagcgatgt gcgtagtcag tcaaactagg gcctgcacga tgcaggtcac 547441 acaggtgtca ccgcgggatg cggtggactt aacctgtgat ccatttatcg gagagtttga 547501 tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cgaacagatg 547561 ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt 547621 aagactggga taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg 547681 ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta 547741 gttggtgagg taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg 547801 ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc 547861 gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta 547921 aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc 547981 taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc 548041 gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa 548101 gcccccggct caaccgggga gggtcattgg aaactgggaa acttgagtgc agaagaggag 548161 agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa 548221 ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt 548281 agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc 548341 cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa 548401 actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca 548461 acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc 548521 ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 548581 gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc 548641 taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc 548701 cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga 548761 ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg 548821 tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc 548881 ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc 548941 ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag 549001 ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga 549061 ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc 549121 gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaattag taatacaaga 549181 tatcacatag tgattctttt taacggttaa gttagaaagg gcgcacggtg gatgccttgg 549241 cactaggagc cgatgaagga cgggacgaac accgatatgc ttcggggagc tgtaagcaag 549301 ctttgatccg gagatttccg aatggggaaa cccaccactc gtaatggagt ggtatccata 549361 tctgaattca taggatatga gaaggcagac ccggggaact gaaacatcta agtacccgga 549421 ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc gaaacgggat tagcccaaac 549481 caagaggctt gcctcttggg gttgtaggac actctgtacg gagttacaaa ggaacgaggt 549541 agatgaagag gtctggaaag gcccgccata ggaggtaaca gccctgtagt caaaacttcg 549601 ttctctcctg agtggatcct gagtacggcg gaacacgtga aattccgtcg gaatccggga 549661 ggaccatctc ccaaggctaa atactcccta gtgaccgata gtgaaccagt accgtgaggg 549721 aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc tgaaaccgtg tgcctacaag 549781 tagtcagagc ccgttaacgg gtgatggcgt gccttttgta gaatgaaccg gcgagttacg 549841 atcccgtgca aggttaagca gaagatgcgg agccgcagcg aaagcgagtc tgaatagggc 549901 gcatgagtac gtggtcgtag acccgaaacc aggtgatcta cccatgtcca gggtgaagtt 549961 caggtaacac tgaatggagg cccgaaccca cgcacgttga aaagtgcggg gatgaggtgt 550021 gggtaggggt gaaatgccaa tcgaacctgg agatagctgg ttctctccga aatagcttta 550081 gggctagcct caaggtaaga gtcttggagg tagagcactg attggactag gggcccctac 550141 cgggttaccg aattcagtca aactccgaat gccaatgact tatccttggg agtcagactg 550201 cgagtgataa gatccgtagt cgaaagggaa acagcccaga ccgccagcta aggtcccaaa 550261 gtatacgtta agtggaaaag gatgtggagt tgcttagaca accaggatgt tggcttagaa 550321 gcagccacca tttaaagagt gcgtaatagc tcactggtcg agtgactctg cgccgaaaat 550381 gtaccggggc taaacgtatc accgaagctg cggactgttc ttcgaacagt ggtaggagag 550441 cgttctaagg gctgtgaagc cagaccggaa ggactggtgg agcgcttaga agtgagaatg 550501 ccggtatgag tagcgaaaga ggggtgagaa tcccctccac cgaatgccta aggtttcctg 550561 aggaaggctc gtccgctcag ggttagtcgg gacctaagcc gaggccgaaa ggcgtaggcg 550621 atggacaaca ggttgatatt cctgtaccac ctcctcacca tttgagcaat ggggggacgc 550681 aggaggatag ggtaagcgcg gtattggata tccgcgtcca agcagttagg ctgggaaata 550741 ggcaaatccg tttcccataa ggctgagctg tgatggcgag cgaaatatag tagcgaagtt 550801 cctgattcca cactgccaag aaaagcctct agcgaggtga gaggtgcccg taccgcaaac 550861 cgacacaggt aggcgaggag agaatcctaa ggtgatcgag agaactctcg ttaaggaact 550921 cggcaaaatg accccgtaac ttcgggagaa ggggtgctct gttagggtgc aagcccgaga 550981 gagccgcagt gaataggccc aggcgactgt ttagcaaaaa cacaggtctc tgcgaagccg 551041 taaggcgaag tataggggct gacgcctgcc cggtgctgga aggttaagag gagcgcttag 551101 cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg ccgtaactat aacggtccta 551161 aggtagcgaa attccttgtc gggtaagttc cgacccgcac gaaaggcgca acgatctggg 551221 cactgtctca acgagagact cggtgaaatt atagtacctg tgaagatgca ggttacccgc 551281 gacaggacgg aaagaccccg tggagcttta ctgcagcctg atattgaatg ttggtacagc 551341 ttgtacagga taggtaggag ccttggaaac cggagcgcca gcttcggtgg aggcatcggt 551401 gggatactac cctggctgta ttgaccttct aacccgccgc ccttatcggg cggggagaca 551461 gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa aaggtaacgg aggcgcccaa 551521 aggttccctc agaatggttg gaaatcattc gcagagtgta aaggcacaag ggagcttgac 551581 tgcgagacct acaagtcgag cagggacgaa agtcgggctt agtgatccgg tggttccgca 551641 tggaagggcc atcgctcaac ggataaaagc taccccgggg ataacaggct tatctccccc 551701 aagagtccac atcgacgggg aggtttggca cctcgatgtc ggctcatcgc atcctggggc 551761 tgtagtcggt cccaagggtt gggctgttcg cccattaaag cggtacgcga gctgggttca 551821 gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg caggaaattt gagaggagct 551881 gtccttagta cgagaggacc gggatggacg caccgctggt gtaccagttg ttctgccaag 551941 ggcatcgctg ggtagctatg tgcggacggg ataagtgctg aaagcatcta agcatgaagc 552001 ccccctcaag atgagatttc ccattccgca aggaagtaag atccctgaaa gatgatcagg 552061 ttgataggtc tgaggtggaa gtgtggcgac acatggagct gacagatact aatcgatcga 552121 ggacttaacc atatttttga atgatgtcac acctgttatc tagttttgag agaacactct 552181 caatttgttt ggtggcgata gcgaagaggt cacacccgtt cccataccga acacggaagt 552241 taagctcttc agcgccgatg gtagtcgggg gtttccccct gtgagagtag gacgccgcca 552301 agcattactt ttatcatcgc ggggtggagc agttcggtag ctcgtcgggc tcataacccg 552361 aaggtcgcag gttcaaatcc tgcccccgca accaaatata tggttaaata aggagtgccc 552421 taagggtgca accaaaataa tcctatacaa atatggtccg gtagttcagt tggttagaat 552481 gcctgcctgt cacgcaggag gtcgcgggtt cgagtcccgt ccggaccgcc attaatgtaa 552541 acgaaacgat catgttttcg ttttttttgt gttttctttt actgtatctt ctgcttggtg 552601 tcatagccaa gctttcttta tatcgggaac atcttggata ttccagcaaa attcgataaa 552661 ctaggaagag cacaaatagg cataagcagg gttgaaagga ggttttggtt catggatgaa 552721 tttgatttga tacatagcat tactccgcgg accattcacc attcttccgt tgatgtagga 552781 ataggtgatg atgcagcgct ctacactgcg aaacacggcg ttcaggaaat tgtttgtgtt 552841 gatactatgg tagaagacgt gcacttcaaa ttacactatt cctcacctga agatatcggg 552901 tacaaggcgt tagccgttaa tataagtgat attgccgcga tgggaggcat tcctaagttt 552961 tatctggtat cacttgcggt accttcaaaa tggactgaat ctgaaatcaa ggcgatgtat 553021 gaaggaatga atgaactggc gaaactatat catatggatc tgattggcgg cgatacagtt 553081 tctaccgctg acaaattagt cgttacagtc actgtaatcg gtgaaattga aaagggacag 553141 gcctgtttgc gcagcttggc aaaaccgaat gatattgtgt ttgtaaccgg tgaaatcggt 553201 tcttctgcag cagggctttc tttattgctg gaagagacta atcctcaaaa ctcatctgtg 553261 gaaacggatt actttatcca caggcataaa cggcctgagc caagagtaag cgtcggcaga 553321 ttatgctcga tttttaaacg ggcagcttta aatgatgtta gtgacggatt ggctagtgaa 553381 ctgaacgaga ttgcagaagc cagctgtgtt tcaattgaaa ttgttgaaag catgcttcca 553441 attcattctg atttgcctaa gcttcatcct aactggaaag aatgggcttt gtttggcggt 553501 gaggattttg agctgacagg gacggtttca aatgaggagt gggaagtgtt gaagcaggag 553561 tgcgcagcgc ttcatcttcc cattacaaag attggctatg tcagggaaaa aacaaaatct 553621 aaagtgatcc taaaaacaga tcaaacatca atgatcttag agaaaaaggg atataatcat 553681 tttaaataag acgggtgact cgtgtgaagc aattaaaatg gagaactgta aatccagaag 553741 aaacaaaagc aattgccaag ctgacggcag cgtttgctaa accgggagac gtcctgacat 553801 tagagggcga tttaggtgca ggaaaaacga cttttacgaa aggttttgca gaagggctgg 553861 gaattacacg tattgtaaac agtccgactt ttacaattat aaaagaatat aacgatggcg 553921 tacttcctct ttatcacatg gatgtgtata gaatggaaga tgaaagtgaa gatttgggac 553981 ttgatgaata ttttcacgga caaggtgtct gtctcgttga atgggctcat ttaattgaag 554041 aacagctgcc acaggagcga ctgcaaattg tcatcaaaag agctggtgat gatgagcggg 554101 aaattacctt tactgctgtc gggaatcggt atgaaatgct ttgtgaggag ttaagtagac 554161 atgacaatat tagcaattga tacatcaaat tatacattgg gcattgcgct gcttcgagaa 554221 gacactgtta tagcagaata cattacatat ttgaaaaaga accactctgt aagagcgatg 554281 cctgctgttc attcattgct gaatgattgt gatatggcac cgcaggacct ttctaaaatt 554341 gtcgttgcaa aaggccctgg ttcatacaca ggagtaagaa taggtgtgac gttggccaaa 554401 acacttgcct ggtctttaga cattccaata agtgctgtat caagtcttga gacgcttgcg 554461 gcaaatggcc ggcattttga cggtctgatc agcccaatct ttgatgctag acggggacag 554521 gtgtacacag gtctgtatca atataaaaat gggcttttag agcaagttgt tccagatcaa 554581 aatgtgatgc tggcagattg gctggagatg ctaaaagaaa aggaccgccc tgttttgttt 554641 ttaggccatg atacttctct tcacaagcag atgatcgagg atgtgcttgg aacaaaagga 554701 ttcattggaa ctgccgccca gcataacccg cgcccttcag aattggcttt tctcgggaag 554761 gaaaaggaag cagctgatgt tcatgggctt gtcccggatt acttgcggct ggcagaagct 554821 gaagcgaaat ggattgaaag tcaaaagtag ggtgatagga tgaaaacaaa agcagcggtc 554881 agaaatatgc ggcttgaaga tatagatcac gtatacgaaa tcgaagcatc ctcctttacg 554941 tctccttgga cgaaggattc gttttatcat gagctgctgg aaaatccgta tgctcattat 555001 ctcgtgattg aaaaggacgg ccatcttgct gggtattgcg ggatttggat tgtgatggac 555061 gatgcccaga ttacaaatat agcgataaaa ccagagtatc gcggccagtc tttaggagaa 555121 acgctttttc gctcagctgt tgaactgtgc aaagaaaaag acgcaaggcg gctttcgctt 555181 gaagtgaggg tttcgaatca tcctgctcaa ggcttatata agaaattcgg gatgcagccc 555241 ggcggaataa gaaagaacta ttatactgat aacggggaag atgcgttaat tatgtgggtg 555301 acgataaatg agtgagcaaa aagacatgta cgtattagga attgaaacaa gctgtgatga 555361 gactgctgca gctattgtga aaaacgggaa agagatcatt tcaaacgtag tagcctctca 555421 aattgaaagc cataagcgct tcggaggcgt tgttccggaa attgcttcaa gacatcatgt 555481 tgaacaaatc actttggtta tagaagaggc gtttcgcaaa gctggcatga cgtatagtga 555541 tattgatgcg attgcagtaa cagaaggtcc gggactggtg ggagcgcttc ttatcggagt 555601 gaatgccgct aaagcattga gctttgcata taacattccg ttagtaggcg ttcatcatat 555661 agccggtcat atatacgcga accgtcttgt agaagacatc gtgttcccgg cactggcatt 555721 ggtcgtttca ggaggccata cagaactggt ttatatgaag gaacatggat catttgaagt 555781 cattggggaa acccttgatg atgcggcagg agaagcctac gacaaagtgg cgcggacgat 555841 gggattgcca tatccgggtg gaccgcaaat tgacaagcta gctgaaaaag ggaatgacaa 555901 tattccgctt cctcgcgcat ggcttgaaga aggctcttac aacttcagct ttagcggatt 555961 gaagtctgcg gtgatcaata cgcttcataa tgcatcccaa aaagggcaag agattgctcc 556021 ggaagatttg tctgccagtt tccaaaatag tgtgatcgat gtcttggtaa ccaaaacggc 556081 gcgcgcggca aaggaatatg atgtcaaaca ggtcctttta gccggaggag tagctgcaaa 556141 cagaggcctc agagctgcat tagaaaagga atttgcccag catgaaggga ttacgcttgt 556201 cattcctcca ttagctttat gcacggataa tgctgcgatg attgctgctg ctggtacaat 556261 tgcttttgaa aaaggaattc gcggtgcata tgatatgaat ggccagcccg gccttgaatt 556321 gacttcttat caaagtctca cgagataata gcgtgagact ttttatctgt ttgttattaa 556381 cagacaattc acaatttatc cacatatctg tgagtaatta tagagatatt gatggataaa 556441 gggctgaggt cactgttaat aaagtggata aattcagaat attttgtgga tagtgtgtat 556501 aaagcgctta ctttgtttat ttattagggg atgttctgtg gataaaaagc acctctaaaa 556561 agaggtgctt gactttttta atcttcttct gtggatagtt cttcccattc ggacaaaaga 556621 gattccagct cctgattaag cttctcattg tctgcatgga tagcttgtac tttttcatga 556681 tcctgataga cttcagggtc acatagcaat tcatcattgc ggctgatgtt ctcctcaatg 556741 gtttgaacgg tggtttcaat ttcttcaatc cgacggagtc gttggcgctc tttctttttc 556801 cattcttttt cttcctcgta ggaacgtttg gagtcagact tcactgtagc tggcgtttta 556861 tcagtttcct cttgctgatt cattttctcc aattcaagct gctctgtttt tttctctgta 556921 taataatcgt aatctcccag atactcctct atatggcttg aagaaagctc caatactctt 556981 gtggcgattc tgttaataaa atatctgtca tgtgagacaa ataacagtgt gcctggataa 557041 tcaatcagcg cgttttcgag aacttctttg ctgtctaaat ccagatggtt cgtcggttca 557101 tcaaggatga gaaagttggc tttttgaagc atcagcttag ctagagccaa tcttgctttt 557161 tcgcctccgc tcagtgaatg aactggtttc agcacatcat ctccggagaa taagaaattt 557221 ccgagacacg ttctgatttc tttttctggg agcccggggt actcgtccca cagctcatca 557281 aggacacgtt tagaggaagt caactcagcc tgttcctggt cataatagcc gacactgaca 557341 tttgagccgt aagaaattgt tccctgatct ggttttaggg tgtctattaa tgttttcagc 557401 aatgtcgatt tacctattcc gttagggccg acaagcgcag cgctttctcc tcttgtgagc 557461 atgaatgaca cttctgttaa aagcggcggc tggttttcat agctgattgt gagatcctga 557521 acacgaagga cttcatttcc gctctgtttt gtaatatcaa aatgaaagtt tgcggatttt 557581 tcatcgccaa gcggttttga catgacatcc attcgctcaa gctgctttct gcggctttgc 557641 gcccttttgg tggtagaggc tctcgccaga tttcgatcta cgaagtcctg cagctttgca 557701 atctcgtcct gctgcttttc atacattttc agatcttttt catactgcgc ggctttttgg 557761 tcgagataag cgctgtagtt gccgtgatac tttttgcttt ctgctcttga tacctcgtat 557821 acctggttta ctactttgtc caaaaagtag cggtcatgcg aaacgatgag aatggcgcct 557881 gaatagcctt gtaaataatg ctcaagccag gtaagcgtat caatatccag atggtttgtc 557941 ggctcatcaa gaatgagcaa atcaggctgt gttaatagaa gcttacctaa agccagtctt 558001 gttttctggc ctccgctgag gctttgaacc tgtgtagaat cgtcaaaatg gctgaagccg 558061 agaccatgca gcacagatct aacatccgct tcatattgat aaccgccttt atctttgaat 558121 tcctgctgaa gacggtcgta ggttttcatg atgctttcta attcacccgg gtcagctgcc 558181 gccatttttt cttccatagc ccgcatttcc ttttccattg cttttaagtg gtcaaaaaca 558241 gtcagcagct cttcttttat ggtaagctta gaatccaagc cagtatgctg ggcgagatat 558301 cccattgtaa tatctttcgg tttaataatt tcgccctttt catacgaaag ctggcctgcg 558361 ataattttaa ggagcgtgga ttttccggcg ccatttcttc ctacaatggc gatgcgatca 558421 cgatttctga cttccagctt tatattgttt aaaatagtat cagcaccaaa tgatttggac 558481 agctgattaa cttgtaagat catcatatta tttcacctct gctataataa gttaagtgta 558541 gcttatgaac cagaagtcag caaacaatac attggccata taagacatag agaagaaaat 558601 agtgtatgat ctgtttaagg agcgttttaa tatgaatgga ttttctcatt ttaatgaaca 558661 gggcagagcc cagatggtgg atattagcga aaaatcttcg actgtccgta ctgcggcggc 558721 tgtttcaagc gtacacatga agaatgaagt gtacgagaaa atacaaagtc acgatatcgg 558781 caaaggagat gtactggctg tcgcacaggt ggcaggcatt atggccgcaa agcaaacgtc 558841 gaatatcatt ccgatgtgcc atccgctttc attgagcggg gtagatatat cgtttgactg 558901 gaaaataaaa gaagcagaag ttatacttca tataaaagca caggtcaaaa cgaaagggag 558961 tacaggtgtg gaaatggaag cgctcacttc tgcatcggtg tgcgctctta ccgtttacga 559021 tatgtgcaag gcccttgata agggaatggt catcggccct actttcttgc tggagaagac 559081 aggcgggaaa aacggtgact ttaaaagaga actatccgag tataatttgg aggaccaaaa 559141 atgaataagg atcaatcaaa aattccgcag gcgacggcga aacggctgcc gctttactat 559201 cgctttttaa agaatctgca tgcgtcagga aaacagcgtg tatcatccgc tgaactcagt 559261 gatgccgtaa aggttgattc tgccacgatt cggagggatt tttcctattt tggagctctt 559321 ggcaaaaaag gatacggata taatgtggat tatttgctgt cttttttccg gaaaacgctt 559381 gatcaggatg agatgacaga cgtcatcttg attggtgtcg ggaacttggg aacggcattt 559441 cttcactata atttcacaaa aaacaataac acaaaaattt ctatggcttt tgatataaat 559501 gagagtaaaa taggaactga ggtaggcggc gtgcccgtct ataaccttga tgaccttgaa 559561 caacacgtaa aagatgaatc agttgccatt cttacagtgc cagcagttgc cgctcaatcc 559621 attacagaca gattggtcgc attaggaatc aagggaatcc ttaattttac gccggcccgt 559681 ttgaatgtgc cggaacacat tcgaattcat catatagatt tagcagttga gcttcagtca 559741 ctggtttatt ttttgaagca ttattcagtt ttagaggaaa tcgaatagag ggaaaggagg 559801 agcccaaata tgccgatcgg tcctggaagc cttgctgtta tcgcaatcgt tgctctgatt 559861 atcttcggtc ccaaaaagct gcctgaattg gggaaagcag cgggagacac acttcgtgaa 559921 tttaaaaacg ctactaaagg attaacgagt gatgaagagg aaaaaaagaa agaagatcag 559981 taagttagga tgacacgaat gaaagtgaat caaatgtcgc tgctggagca tattgctgag 560041 cttcgaaaac ggttgctgat tgtagcgctg gcgtttgtcg ttttctttat tgctggattt 560101 tttttagcaa agccgattat tgtgtatctg caagaaacag atgaagcgaa gcagcttacg 560161 cttaacgcgt ttaacctgac agacccgctt tatgtgttta tgcaatttgc gtttatcatc 560221 ggcatagtct tgacctcgcc ggttattctt tatcagcttt gggcttttgt gagcccgggc 560281 ctctatgaga aagagcgcaa agtaacgctc agctacattc cggtctctat tttgctgttt 560341 ttagcgggct tatctttttc atattatatt ttatttcctt ttgttgttga ttttatgaag 560401 cggatttctc aggacttgaa tgtcaatcag gtgatcggaa ttaatgaata ttttcatttt 560461 cttctgcagc tgacgattcc gtttggactg ctgttccaaa tgccggtcat cctcatgttt 560521 ttgacaaggc tcggaattgt gacaccgatg ttcttggcga aaatcagaaa gtatgcgtat 560581 tttacgctgc tggtgatcgc agccctgatt acaccgcctg agcttctgtc ccatatgatg 560641 gtcacagtcc cgcttttgat tttatatgaa atcagtatcc ttatatcgaa ggccgcttat 560701 cggaaagcac agaaaagcag tgctgccgat cgggacgtgt cttctgggca ataataaaaa 560761 atccatttct catgcgagaa atggattttc tttatttttg gttctttttg attttaaatg 560821 aaaaggcgaa catcttaaaa gaaatgctga tgttgtaagc ggcgaacacc atcagcagga 560881 tggagtaaaa tgaccacatg ctgcctggcg agcttgcggc aagataagta aagatgcacc 560941 ctacggcaaa gtagatcatt ccccaaacta ccgggtttct cataaaaata atcctccaat 561001 aatcaattgc atttgtgtgc tctgctgttc aaggtaatta cgaacaggct caagctgcat 561061 gatgacgacg aatgtattca tcattaaatg ggcgaaaatc ggcacccata tccgttttgt 561121 tctcgcatat aaaaaggcaa aggtaaagcc cattgctgta tatagaagga gatgcttcaa 561181 atcagcgtga acaataccga agataaccga gctgatcagt cctgcgaaaa agaaattcgt 561241 tttttcgtac agcgcgccga aaatgatttt tctgaagatg atttcttcta atataggccc 561301 gacgatggaa gaaacgataa tcatgagcgg gactgcctga atgacatcca gaatcgcttg 561361 tgtattttct gattctcttc cgatgccaaa aacataatat tcaatagagc ctgctattcc 561421 ttgagagaaa agggcaatga aaaaaccggc tatcgcccaa aggatagaaa gtccgattga 561481 gtccttctgt ccgtttcgca gcgtttcttt cggaacggtt ctcagaatga gcagaacaac 561541 aacgagacag gcgataaagc tgataacgga ccataatcct tgtgcatgca gcatattttc 561601 atctgtaggc tgtcctccgg cataaccgaa tttaaataac aagggaatcg cgattaatgc 561661 ggaaaactgc atgatgatat atgtcaaaat aataaaccaa tactgttttc tcaaatggta 561721 tgtactcctt tgttaagtgg gtttcgttca tctacagcta ttgtaacata atcggtacgg 561781 gggtgaaaaa gctaacggaa aagggagcgg aaaagaatga tgtaagcgtg aaaaattttt 561841 tatcttatca cttgaaattg gaagggagat tctttattat aagaattgtg ttagcactct 561901 ttagtgctga gtgctaaaat tacatattca tactattgag gaggttattt cattgttaaa 561961 gccattaggt gatcgcgttg tcattgaact cgtagaatct gaagaaaaaa ctgccagcgg 562021 aattgtgttg ccggattctg caaaagaaaa accgcaagaa ggcaaaatcg tggcagctgg 562081 ttcaggtcgc gtgttagaaa gcggagagcg cgttgcttta gaagtaaaag agggcgaccg 562141 cattatcttc tcaaaatacg caggtactga agtgaaatac gaaggtactg aatacttaat 562201 cttacgtgaa agcgacattt tagctgttat cggctaattc ttaaataaac aatacttaaa 562261 acatttgagg aggtcttgta aacatggcaa aagaaattaa gtttagtgaa gaagctcgcc 562321 gcgcaatgct tcgcggtgtc gatgcacttg ctgatgctgt taaagtaact ttaggaccaa 562381 aaggacgcaa cgtggttcta gagaaaaaat tcggttctcc gttaatcaca aatgacggtg 562441 taacaatcgc taaagaaatc gagctagaag acgcgtttga aaacatgggt gctaagcttg 562501 ttgctgaagt agccagcaaa acaaacgacg ttgccggtga cggtacaaca actgcaacag 562561 ttcttgcgca agcaatgatc cgtgaaggcc ttaaaaacgt aacagcaggc gctaaccctg 562621 taggcgtgcg taaagggatg gaacaagctg tagcggttgc gatcgaaaac ttaaaagaaa 562681 tttctaagcc aatcgaaggc aaagagtcta tcgctcaggt tgctgcgatc tctgctgctg 562741 atgaggaagt cggaagcctt atcgctgaag caatggagcg cgtaggaaac gacggcgtta 562801 tcacaatcga agagtctaaa ggcttcacaa ctgagcttga agttgttgaa ggtatgcaat 562861 tcgaccgcgg atatgcgtct ccttacatgg taactgactc tgataagatg gaagcggttc 562921 ttgacaatcc ttacatctta atcacagaca aaaaaatcac aaacattcaa gaaatccttc 562981 ctgtgcttga gcaggttgtt cagcaaggca aaccattgct tctgatcgct gaggatgttg 563041 aaggcgaagc acttgctaca cttgttgtga acaaacttcg cggcacattc aacgcagtgg 563101 ctgttaaagc tcctggtttc ggtgatcgcc gtaaagcaat gcttgaagac atcgctgtcc 563161 ttactggcgg agaagtcatc acagaagatc ttggccttga cctgaaatct actcaaatcg 563221 ctcaattggg acgcgcttct aaagttgtcg ttactaaaga aaacacaaca atcgttgaag 563281 gcgctggcga aacagacaaa atttctgccc gtgtgactca aatccgcgct caagtggaag 563341 aaacaacttc tgaattcgac agagaaaaat tacaagagcg tcttgctaaa cttgctggcg 563401 gcgtagctgt catcaaagtc ggcgctgcga ctgaaactga gctgaaagag cgtaaacttc 563461 gcatcgaaga cgccttgaac tcaactcgcg cagctgttga agaaggcatc gtatccggtg 563521 gtggtacagc gcttgtaaac gtatataaca aagtcgctgc agttgaagct gaaggcgatg 563581 ctcaaacagg tatcaacatc gtgcttcgcg cgcttgaaga gccaatccgt caaatcgcac 563641 acaacgctgg ccttgaagga tctgtcatcg ttgagcgcct caaaaacgaa gaaatcggcg 563701 taggcttcaa cgctgcaact ggcgaatggg taaacatgat cgaaaaaggt atcgttgacc 563761 caacaaaagt tacacgctca gctcttcaaa acgctgcgtc tgtagctgca atgttcttaa 563821 caacagaagc tgttgtcgct gacaagccag aagaaaacgg tggcggcgca ggaatgcctg 563881 atatgggcgg catgggcggt atgggtggaa tgatgtaata aagggatatt aacccttata 563941 catcaatgtt ttaaccgtct taaaaaacta gacaaagcgt gaataaaaaa agagaaggtc 564001 tttcatcagt ttactaaact gttgggagac cttttctcca tattagcggt catatgagca 564061 taaatgtcca tcgtcgtatt tatgtccgaa tgaccaaatt gttgctggat ttctttaatg 564121 cctactcctg cctcaattag taaggaggta tgggtatgcc taaaagagtg gggggtgaca 564181 ttctttttat cccagctttt ttgagcagcc gtttaagtct agtctcaata acctttctta 564241 attgcggatg accatcctcc cgctcaaaaa taaatgatga gtcttgataa atcaatctat 564301 ttttaagctt aatttcattt tgataaattt tatttttttt tagtagattg acatcgtttc 564361 atcaattcga acgatatcaa cagatcctgt tgttttaggt gttagcaatt ggtatttttc 564421 aatttgattg ttaggggtgt atagggtctt tgtgacctgg cttatcattg aaatctgtcc 564481 attttaaagc aagaagttca ccaattctta ggtcggtcta ggcaagtacg gtaaagacca 564541 aatggtccat ttctagcccg tcagattgag cgagctttag aaaatgtgtc agcacctctt 564601 tttccaatgc tttgttgctt cttgggtaat tgaaaatccc cagttgggtt cattttaata 564661 atcccttgag ttttagcttt tcggaaaatc atacggccgc aggcatgaat acctcccaaa 564721 caattgtgac tgtattgctc gttcagttct aacgtgcggt cttcatacat ttttttgtgt 564781 tttgctaatc gggtattgac ccaatactgc gataaaatgc atcattttct tttcactggc 564841 ccgtacactg cttattttta ccccactccg gttgtaaatc ttaagccaac cttttgcaaa 564901 tgttttgaag ggcatatctg actccttaat aaaagtcccg ttgtcgtttt ggagttctac 564961 gtgacgggct gctactgggg cttctttctt tgttttaaat cttcctttgg atatttctag 565021 acgttttttg gttaaagggt caatgcctag tagatatgat aactccacgt cttaccgcat 565081 tgcttgagtt ttgccattta tttgtcccta actaattttt tttcatcaaa ttggtcttta 565141 agtgagttta ataatttttg tttctctcga ctggtcaata attgcccttc atatttcaaa 565201 agattggata aatttgagat ggaatcaatc ctgatggatg gtaccgtaga ctttaataag 565261 aaacgaaagg ccaactgcga cttcagttgg cctttcctat ttataataaa gaaattgagt 565321 gagattgctg acagaactac gtactactcg ttttctttag ttgcccttgc taatcgttca 565381 acctctcccc gaatcccaat cgcaggctcc cacgaatcaa tcaaacgaat cgccttctga 565441 ttagattcca ccgctttcgt tttctctcct ttacgataca acagctgcgc cattccgtag 565501 tgatagtaga tcagttcaac ttgattggcg ttatgtttgt catagagcat ttgctcaaag 565561 gcttcttccg ctttttcaaa ctgatcacat ttcacgtaag cgacacccag attgaaatag 565621 gcttctatcg ttttttcgcc gccgtatgtg gagctgattt catttgccgc ttcgtataat 565681 tgaatggctt ctacatgata acctctcgca aagcttaagt caccgcgaac caatagaact 565741 ctgtgttgaa tggtagggga aatcggttga ttttcgattt cgtttaaaat tgtctctgct 565801 ttttcctgtt gcccgtcttt taaaaacagc cttgctttga gtgcatgtcc ccaaaccttt 565861 agatcatagg catcgtgagc gtctgattgt tcaagaatct tcagcccggc ttctatttgc 565921 tgaagcgctc cgtctaaatc attgacttcc atcaatgccc agcctgaggt gtcgattcgg 565981 aagtacgctt ctcgtgtgtg ttggcctaag tgatgggcgg cgtcggccgc tttgcgtccg 566041 tattcgattc gcaggggcag gttgattctg cttagaaaat ggctaatgcg ggtgatgagt 566101 tcgattagga tttctttttg ttcagtttca cttgcccatt ggatgacctt taagatgttt 566161 ggccattctt gtttcatttg atctaagttc cgtcccagca ggtagctcca atagatagag 566221 ttgggctgtt cccgctttaa atgggtttcg gcataatcaa tataatagtg cgcccagcga 566281 ttgcgggctt ctttttcata ttcgtgctgt tcggacaagt gctgttctcc gtaagcgaca 566341 acggtttggt gcgctaagta ttgtgtcctg ccttggcttc gttccggctg aatcagcgca 566401 tatgaccgca tttgttccat agcgtaatga aaacggcggg cgtctaatcc ggctgctgcc 566461 gccaggcttt tttcatcagg cggcttgctg aaaaagcaaa gcgtctgcca gagctttcgc 566521 gtatcttcat tgcatctatc ccaggtgcgg ccaaagagga attcaaacaa ttccagcagt 566581 gagtagcctg cttttccaag ctcatgaatc agctgctgag cggggatgtc atcgtctgac 566641 atataggcaa tgctgagtgc catggctttc gggtttccgg cagtcgctga aatgaattcg 566701 tttttcaggt cagatgatag atgtaacagc tgctccagct tttcccgttt acgtgggagg 566761 ttgcatgttt gtaagcagtg atgcacttct tgttgaaaaa attcgtgggc atctgtttgg 566821 tcaagaccgc ttagctgaat ggctgtcatt tctccgaagc tttcccgata agtttgcttt 566881 acgttttccc gcgctgtaag gagaactttt acgccttgcg gaaggctggt gataaattca 566941 tgaatgtcac gttctgcagt atcaatgctg tcaacgatca gcaggatcgg tttttctcta 567001 gtgtaattgg ctaacgcatt gcggacgaca aaccgtttta cattgattga tttatcgatt 567061 tgttctttgc gtccgagctg ataggcgatc gtatttaaaa aatcgctaaa gcttaatcct 567121 ttccaatcag cgctgaccca gatgatgctg ttgaatgccg gccaaactga agtatcgtcg 567181 acacaggaat aggcggcttc aagagcaatt gtggtttttc ccatgccggc ccagccggtg 567241 attaaacaga ctggtgatgg agaaagcatc cattgccgta tcgcttccat atcaaagctg 567301 cgtccgataa agcgtccgga ccagcgtgag ggtaaattat gcgtgatggg ctgttctgta 567361 agcgcattcg tttcttggcc gggtctgtca tgaaacagcc gttttactac attttcaatt 567421 tcgccttcac tcggagcccc gaataatccg tcttttcgca gtattttcgc ttttttcaaa 567481 caggatgctg cccatacagg caatgcgggt ttgatgactg ggatagtggt ggcttccagc 567541 aagtcggtca accactcgat atccaagtcg gtcttttcga gaatgatcca gatcattccg 567601 aacagttttc cgtcgtcgat tcttccggga atgtagtttg cccccatctg tccgatccag 567661 cttttgatcg tgtttgggga gactcccagc tggagtgcga ttttatctat gtaagactgt 567721 cctgtttttt cattcttttt ccttctgact ttataatcag gatgaagttt tagcgttttg 567781 acgccaggtg ccagcatttg tgcaaattgt tttcggtttt caagttcagc cataagcctg 567841 cacctcctat tagtactatt ttatcaatcc agcgtttttt gtatatgaaa aaataaaagt 567901 acagtgccgc tgtcctttta tacagcagga aaggctgttg aacgtgttaa aaagcagata 567961 aaatgggggc agtaacagag aaaacaaaaa tgtatgcact tacattttat tttctaaaga 568021 aaggaacttg ccaaatgact cacacagtac ctcaaaacat gaaagcggct gttatgcaca 568081 acacaagaga gatcaaaatt gaaacattgc ctgtgcctga tatcaatcat gatgaagtgt 568141 tgattaaggt gatggctgtc ggaatttgcg gatctgatct gcattactat acaaatggcc 568201 gaataggcaa ctatgttgtg gaaaaaccat ttatccttgg gcatgaatgt gcgggtgaaa 568261 ttgccgctgt cggatcatct gtcgatcaat tcaaggtggg agaccgcgtc gctgtagagc 568321 cgggtgttac gtgcggacgc tgtgaggcgt gcaaagaagg acgctataat ctttgcccgg 568381 atgtacagtt tttggctaca ccgccggtag acggtgcgtt tgtccaatat attaaaatgc 568441 gtcaggactt tgttttttta atcccagact cactttctta tgaagaagct gctttgatcg 568501 agccgttttc tgtcggtatc catgcggcgg ccagaacgaa gctacagccc ggatcaacga 568561 ttgcgattat ggggatgggc cctgttgggt taatggctgt tgccgcagct aaagcatttg 568621 gggcaggcac aatcattgtc accgacttag agccgctgcg gttagaagct gcgaaaaaaa 568681 tgggagcgac tcacattatt aatatacgtg aacaggatgc acttgaagag attaaaacga 568741 tcacgaatga tagaggcgtt gatgttgctt gggaaacagc agggaatcca gcggcattgc 568801 aatccgcact ggcttctgtg cgccggggcg gaaaattggc gattgtcggt ttgccttcac 568861 agaacgagat tccgctcaac gtgccgttta ttgcggataa tgagattgat atttacggga 568921 tcttccgtta tgccaatacg tatccaaagg gaatcgaatt tcttgcttca ggcattgtgg 568981 acacgaagca tctagtaacg gaccaatatt cgctggagca gacgcaagat gcgatggagc 569041 gggcgcttca atttaagaat gaatgtttaa aagtgatggt gtatccaaat cgctgagtga 569101 acagggagga tcttcgtatt ctccctcttg tttactggaa atgaaaacgg attcttgggg 569161 tgggaaatga tgattggaac agaaaaagta acggcattga aggcgaagca tcagtcaaaa 569221 tccagcaccg gcctgtcctg gtttgaacga atcggttatg gattcggcga tatgtcgtat 569281 aatattatct ttcagtttgt aaacgcatac ttattatttt attatacaga cgtcggcggc 569341 attcagcctg cggtaatcgc aactttgttt cttgttgtgc gtgtgctgga tgctattttt 569401 gacccgatca tgggattgat tttagataaa acgaatacaa ggtggggaaa agcaaggcca 569461 tatttgctgt gggtggcatt tccttttgcg ctattcacat tcttatgttt cacgacgcct 569521 catttcggtg agaccggaaa tatggtatat gcgtatgtca cttatattct gcttgggatg 569581 tcctttagta tgcaaacgat cccggtgaac agcttaacgg ggcggatgac gaattcggtg 569641 gaggaacgaa cggttctgac cacaacccgg atgattttgg tgtatatcgg cattctttta 569701 tccatttcct gtgcgacacc gcttgcaact gctatcggag gagaggatca ggcgtttgga 569761 tttcagatga cggcgctcat ctatgcggct gtcagcatcg ttttgaatct atttagtttc 569821 tttactgtac gggagcggat tcagcctaaa aagagaaaaa aacaagggat caaaaagacg 569881 ttatccgttt tattcaaaaa caaacccttg ctcatgttaa tttcatcatt tttggctttt 569941 gcgatcgggt ttaatattaa gctcagcacg atggtgtatt attttacgta taacgtaaac 570001 cataaagagt tcgtgtttat gggcaccgtt ttatttttcg gggcagcgct gatcagcaat 570061 ttgtttattc ctttcttttc tgagaagtgg ggcagaaaac aagtcatgat tatcacggca 570121 gctctatcgc ttatttctta tgccggcctg cattttacgc cgtattcttc aattccactc 570181 attttcattt ggcttttcgc ttcgggattt ttcacaacgc ctttaaatac gcttgcttgg 570241 ggaatggttg cggattgcgt cgattatgcg gaatggaaaa ccggaattcg cgcggatggt 570301 gttgtgattt cgagcatgag ctttattaat aagctgggtg ttgcgttagc cgggtcattt 570361 tcggccattt atttaggaat cgccgggtat gtggcgaata cagaccagac agttgcgtcg 570421 ttgaatgcga ttaaaaatat gaatgctttg attccgggat ttttcatttt gctttctatt 570481 attcttatcg ccttctatcc tttaacggaa aaaagatata aacacatcat ctctgagctg 570541 gagcaaaggt ctgcgagata aatagatgta aaatttttaa tattcaatgt tgtatttatg 570601 gcaaaaagta atatactgag actgtaatct agactttata aatgagtgtg ataatatgcg 570661 tagtcattct gtagtttgta ttggggaatt gttgattgat ttcttttgta ccgatgttga 570721 cgttgattta atggaagggc gccaattcct gaaaagtgcc ggcggggcac cggcgaatgt 570781 gtcggcagcg attgccaagc tgggcggaga cgccgctttc agcggaaaag taggaaagga 570841 tccgtttggg tattttctga agcgaacatt ggacgctgta catgtcgata cctctatgct 570901 ggtgatggat gagaaagcgc ctacaacgct tgcttttgtt tcattaaaac aaaatggaga 570961 gcgtgacttt gtttttaata gaggcgcgga cgctttgttt acgctggagg acattgacca 571021 ggaaaaacta aacgaagcga aaatccttca tttcggctct gcgacggcac tgttatcgga 571081 tccgttttgc tcagcctatt tacggttgat gtcgattgcg aaagacaatg gacagtttat 571141 ttcgtttgac cctaactacc gtgaagattt atggagggga agagtctcag agtttgtaag 571201 tgttgcgaaa aaagcgatcg ctgtaagtga ttttgtgaaa gtcagtgacg aggaacttga 571261 gattatcagc ggtgtgaagg atcatgaaaa gggagttgcg atccttcatg agatcggagc 571321 caacattgtc gctgtgacac ttgggaaaag cggaacgctt ctttccaatg gaaaagaccg 571381 tgaaatcatt ccaagcattc cggtgacatc aattgactca acaggggcgg gagatgcttt 571441 tgtcggtgcg gctttatatc aattggcaaa cacggatcag attcaatctg tagatgctga 571501 ttttgtgaaa ctgcgtgaga ttgtggcgtt tgccaataag gtcggagctc ttgtgtgcac 571561 taaaattgga gcgattgatg cactgccgag tttggatgag attggagttt ctttgtaaat 571621 cattgaagat gtttcttgaa agtctttgga cttttggggg catctttttt tattgcttac 571681 atttttgttc aggtaaaaag ttgtatattt tttgtttgaa atgtcatttt ttattaaaaa 571741 agtgaaactt ttaacgataa taaatagtat atgtaacaag ggttaccgaa ttagctttag 571801 gaggaacgat ataatgagta taattggaag atttaaagat attatgtctg cgaatatcaa 571861 tgctttattg gacaaggctg aaaatccgga gaaaatggta gatcaatatt taagaaatat 571921 gaatagcgat ttggctaagg ttaaggcaga aacagcagct gttatggctg aggagcagag 571981 agcaaaaaga gaatatcacg aatgccaggc ggatatggaa aagatggaaa gctatgcaat 572041 gaaggcgctg caagccggga atgagagcga tgcgagaaaa tttcttgaaa gaaaaacatc 572101 tttggagtca aagctttctg agctgcaggc ggcgaatcaa attgctgcaa ccaatgccgc 572161 acagatgaga aagatgcatg acaaattggt atctgacatt ggagagctgg aagcacgcaa 572221 aaatatgatc aaggcgaagt gggcagtagc gaaaacgcaa gaaagaatga acaaactggg 572281 cgcttctgtt tcaagtacaa gccaatcaat gtctgcattc ggccgaatgg aggacaaagt 572341 aaataaggca cttgatcagg ccaatgcaat ggctgaactg aacagcgctc cgcaggatga 572401 tatggctgat ctgtctgcaa agtatgacac tggcggttca agccaggttg atgatgaact 572461 tgcggcgtta aaagcgaaaa tgatgctcga taagtaatac ataggaggcc gcagctttcg 572521 gctgcggcgt cattttatca taaaatgtga gagggaacgg taatgataat atcttataag 572581 tgtccgaact gcggcagtga tatggcattt gacagtgaaa ccggctcgtt atcctgcagc 572641 agctgcggaa gacaggacaa tattgaaagc cttccgaaag aaaacattgc ggcacggttt 572701 tctgatgatg aagcaaaaga atatcaatgt aaaaactgcg gtgccgtttt gatcacggaa 572761 gctgaaacga cagcaacgac gtgcagcttc tgcggaggtg ctgcaatact tgccgatcgt 572821 ttatcaggac atttggcgcc ggcgaaggtc attccattta caatcagcaa gcaagaagcg 572881 gagcaggcat ttcgaaagtg gtgcaaaaaa ggccttctga caccaagagg tttcatgtct 572941 gctgatcgta tcaaaagcat caccggcatg tatattccat tttggatgtt tgatttaaat 573001 agtgaagtac aggtgagagc aaactgtacc agagtccatc aatatgaaga aggggattat 573061 atttgcacgg aaacagagca ctttgaagcg tttcgtgata tcaatctcga ttatttgaaa 573121 atccctgtcg atgcctctga aaaaatgaaa gacgaattaa tggacaaatt ggagccttat 573181 tcatacgaag agctgaagga ctttcaaacg gcatatttgg ccggttatat tgcggaaaag 573241 tacaattata ccgatgagga gctttttccg agggcaaaag agaaaatcag cagttatata 573301 gattcataca tccattctac tttttccgga tatacgtcag tcaatgtgag ggacaaacat 573361 attcacacga aaaacgtgaa cagcttttac gttttgcttc ctgtttggat ggtcagttac 573421 gattatgaaa gagcggagca tatctttgcg atgaacgggc aaacaggaaa ggtcgttgga 573481 aagccgccga tcagtcgagg aaaagtggct gcatggttta gcggaatagc aggcgggaca 573541 tttcttgcgt tgaagctcgt ctcattgatg atgggaggcg gattttgatg cgtggatttt 573601 ttgggaaagc gatctttgtt gtgctggctg ttttcatcat gatgccttta ctgggtatcg 573661 aagcggtaag agcctctgaa ttgcagcagc atgtgtacga tcgcgctcat ctattgtcaa 573721 aagcggagat cggaaaactt gaatctctct cggcaaagct gggtgcaaag agggacactg 573781 atttcatcat tattacgacc aaaagcacaa acggtgaaga tattgcagac tataccggcg 573841 atttttatga tcgttacgga aaaggcagta cagccattct gacgattgat atgacaaaca 573901 gagaagtgtt tatcgcaggc tttaaaaaag ccgaacagta tttggacaac agcaggctca 573961 atagcatcag aaatacgatt tcatctgatt tatccaatga aaattatttt gaagcttttg 574021 agacatatat tcagctttcc tataaagata tgggcataaa accgggagta aaccctgaca 574081 acatattctt tacatggtgg tttcagctga ttgctgccat cgcagtcggg ggaattgcgg 574141 tttcaatcat gctttatcat gcaggcggca aagtaacggt taatggaagt acatatatgg 574201 atcagcgtac gtctgatgtg attgatcaat acgacactta tattagaacg actgtaacaa 574261 gagaaagaaa accatcagat aaagacagcg gcagcgatgg cggtgttacg aaaggcggca 574321 cgtcatacag tgggagccgg ggcagttttt aaatgtaaga aatagagaaa gggagaggcg 574381 taatgtcgtt tttcagaaat caattagcga atgtagtaga gtgggaagaa tttagagatg 574441 atatgatttt ttataaatgg aacaatcgtg aaatcaaaaa agggagccgt ttaatcattc 574501 gtcccggaca ggatgctgtc tttttgaaca atgggcgggt tgaaggagtc tttcaagatg 574561 atggcgatta tgatattgaa tcagaaatta ttccattcct ttcaacgtta aagggcttta 574621 agtttggctt taacagcggc atgcgagctg aggtgctgtt tgtcaatacg aaggaattta 574681 ccgtaagatg gggaacaaaa caggcgataa atattccggc agcgggaatg ccaggcggga 574741 tgcccattcg cgcaaacggc acatttaatt tcaaggtgca ggactatatc agcctgattg 574801 ataaaatcgc tggcgtgaaa gatcaatatt ttgtagagga tattaaaacc cgtatcattt 574861 ctattctgga tcagcttctc atgaagtgga tcacaagaga agggaaagat atgtttaatc 574921 ttcaagcaaa cgcttttgat attgccaagg gaattcaaga ggacttagat atgcaattaa 574981 taagcgacgg gatgacggtc actggttttc aaatcatgag ctttaattat cctcaagagg 575041 ttcaagatat gattacaaag aacgcttcct acggtatggt tggggatgtg aacagatacc 575101 agcaaatatc aatgacggat ggaatggcat ccggaaagat gagcggaagc ggagcggctt 575161 cggatatggc tggaatgatg atgggaatga atatggccaa tcagatgatg aaccaaatga 575221 atcagaatca gcaggcacag tcatcaggcc cacagtcaac tggcagcgga agcaaaccga 575281 atttctgtcc aaactgcgga acaaaaacgg gcgaagccaa tttttgtccg aattgcggcc 575341 agaagcttgt ataagaatca tacagtgaaa agtccggagt gatcagcact cgggactttt 575401 ttatttagga gaataagcat tacctattgc ttgctcctga acaggccatt ttcgagcccc 575461 cgcttggata attcccagca gcaattgacg acgttccttt attgaattga cggcaatttg 575521 aaatgtttgc tttgataaag ccggtatgcc tgattgttga agctttgaga tgtctggttc 575581 tggcggcgct tgttctgcag gatggatata ggcagtatga acggtatcca gatagttttt 575641 gatacttgag cgcgcttctt tgatatgaag ctgattcggc tgatattgtt caggaattcc 575701 gtatttgaaa atggttagag cctcatccaa tacagcaaca gctataatgg atgattcctg 575761 atgctgcgtg ctgtggtaaa aatgaaggat ggggaaggcg ttatgctgag cggtcagctt 575821 tcccagttct gatgaggcag cgacaagaag aaaatcaatg tcgtgaaaat ctttgccatt 575881 ccatgcatta tggacgattt cagttccgtc atgccctaga cttaatacac tttgggcaaa 575941 ggagcgtttt tgattaaccg cactcaagac ggaaatcaaa tacgtgacag aaaatgtgat 576001 ggtaagcagt ccttgagctg tttcaataat cgtgacaagc ttccataggc ctccgttcgg 576061 agcgaggtcg ccatttccta atgtaaacat gacatagccg gaaaaataaa ttcggtctga 576121 ccaggaagcc ggttcttttg attgagtttc cataagtgag tgagggtcac tcgagtaaat 576181 caaaacccac ccgctccaaa atagactgat ccatatcact aacgtcaggc ataacagcag 576241 aggaccagcc atacttagaa cctttgcgtg gtcaccgctg attttgcggc agcccttcca 576301 cagccaggca gacaggcatc ttgtgatcgg gccggcaccg ctctctaacc ataacgtggt 576361 ccataaaaaa tcaatcatcc ccgctgtcaa taataaaagg cctgcaatga tataaccctc 576421 attcattttg gttgcctccc ttaagtcagc cttcttttat tttcttctct atttcctttt 576481 atcctgagtc tgaaacaatt gaacgaatgt ttgattttac agagaaaaat aggtgggagt 576541 tacccaacac ttactcattt ttcaatatga acagaaaatc acaagatttt tgacttgatt 576601 cacacatttt catgaagaaa aacgttcatt ttccccttga attggtgatt ttccttttat 576661 agagtaaaaa attttcagaa atttatattg actgaaagcg tttttataat tatgataata 576721 tcagatataa caaaaatgtc actataacat cactacaatt gaactattaa gtgactaata 576781 aataccaaat gaacgaggtt atgcacaaag aaatgaccat tgttctttta acgagaaatg 576841 aaatcgcttc catagggatt gacatgctaa gaagaaggga aggttatgag gttattggat 576901 aaaaacatga acaactattt tctgaagcct gcttacgaaa tgtgaggaag gcagcagccc 576961 tggaataagt ttttgacata cgcattttga aaaagactgg gggaaacagt atgaataaac 577021 aaggaaatca aatgtcattt ttacgtacaa ttattttagt ctccactttc ggcgggcttc 577081 tttttggcta tgataccggt gtgctcaatg gagctttgcc gtatatggga gagccggatc 577141 agcttaatct caatgccttc acagaaggcc ttgtcaccag ttcacttctt tttggagcgg 577201 cactgggtgc tgtgtttggc ggcaggatgt ctgattttaa cggccgccgc aaaaatattt 577261 tgttcctcgc tgttatattt tttatttcaa cgattgggtg tacgtttgca ccaaatgtta 577321 cggtcatgat tatttcccgt tttgtgctcg gtattgcggt tgggggtgca tccgtaacgg 577381 tgcctgccta tttagcagag atgtctcctg tggaaagcag gggacggatg gtgacgcaga 577441 acgaattgat gattgtatca ggacagcttt tggcctttgt ttttaatgcg atccttggaa 577501 caacaatggg agacaactcc catgtgtgga ggtttatgct ggtcattgcg tcacttccag 577561 ccttgttcct gtttttcggc atgatcagaa tgcccgagag tccccgttgg cttgtttcta 577621 aaggaagaaa agaagatgct ttgcgtgtat tgaaaaaaat cagggacgaa aaacgggcag 577681 cagctgagct gcaagaaatt gaattcgctt tcaaaaaaga agaccagctt gaaaaagcga 577741 catttaaaga tctttcagtc ccatgggtgc gccgtattgt gtttattgga ttagggattg 577801 cgattgtaca gcaaattaca ggtgtgaatt cgattatgta ttatgggact gaaattctaa 577861 gaaattccgg tttccaaacg gaagccgctt taatcggaaa tattgcgaat ggcgtgattt 577921 cggtattggc aacattcgtc ggaatctggc tgctgggaag agtggggcgc cggccgatgc 577981 tgatgacagg cttgatcggt acgacaacag cattattgct aatcgggata ttctcacttg 578041 tacttgaagg atcaccggca cttccgtatg tagtcctgtc attaacggtc acatttcttg 578101 cttttcagca gggcgccatt tcaccagtga cttggctgat gctatctgaa attttcccgc 578161 ttcgccttcg cggactggga atgggtgtta cggtattctg tctgtggatg gtgaattttg 578221 cagtcagttt cacgtttccg atattgctgg cagctatcgg gctgtccaca acgttcttta 578281 tcttcgttgg attaggaatt tgctctgtct tgtttgtgaa gaggtttttg ccggaaacga 578341 aagggctttc gcttgagcag ctggaggaaa acttccgcgc ttatgatcac agcggggcaa 578401 agaaggattc tggggctgaa gtgattggat aatttaaaaa agaatccgca cccgagtgcg 578461 gattcttttt ggtttcaaat tagttaggtc taacaaggat tttgacttgg cttttctctt 578521 taataagagc cccgaagcct tcctcgatca aatcatctag tacgattttt ttcgttacga 578581 gtttgtcggc tgagaaatag ccttctttca ttaatgacaa tacagccggg aagatgtcgc 578641 ggtatccgat aattcctttt actgtacgtt ctttgattac gatatcgttc ggatggattt 578701 cagcaccttt ttcccaaatg ctgacgatga cggtttcacc ggcaattgta gtggactgga 578761 tggcttgtcg taacaccact gggacaccag tgacttcgaa tgctacgtca acaccgcctc 578821 ctgtacgttc tgcaatctca gcgactacat cgtctgtttt agacggatca acgatgatcg 578881 cgccaagctc ctcagctttt tgctggcgtt caggagaaag ctcaacagcg taaatatcag 578941 ttgcaccggc agccttcagc gcttcaatga caagaagtcc gatcgggccg cagccgaata 579001 cagccgcttt gtcgcctgct ttgagtttgc ttgagcggac agcgtataga gcaactgcag 579061 aaggttcaac gagcgcgcct tgttcatatg ataattcatc aggaagtttg aacaaaagct 579121 cttcatccac agagacgtat tcagagaaac cgccgcctcc gccggctaag ccgaggaatc 579181 ccatttgttc atcaaggttg taggcgcctt ggtggccgtg tgtagcaaaa atcggctcga 579241 ctacaacgcg gtctccaact ttataatttt caacgccttc tccgacttcg acaacttcac 579301 cggagaattc atgccccatt gtgacaggtg ccgtttcatt tgttaatggg tgcggtttgt 579361 caaccggaat aaagatcggg ccgcccagat attcgtgtaa atcacttccg cagatgccgc 579421 accatttgac tttgatcttt acttttcccg gctccgtttt tggctcttcg atatgttcaa 579481 tacggatatc cttttggtta tgccatcttg ctgccttcat ggattaccac tcctataact 579541 tttgatgtga gtaattccgc accggtcaat atgaactgtt cacaaaatcg ccatttttaa 579601 aaccaaaaaa gaaatgaaat ttttatataa tataatctac gtttttttga aaaaaagaaa 579661 ctttaaagaa aaaagggtct cgcacactct tttttcttta tatgagagta tcaatcgttt 579721 acatagctat gaatttggtt tgaacaatac ggtaatggtt cgttcatatt gaatgcgaca 579781 actactctat caataattat aactctaata ctgctattat aataggataa tcttccatgg 579841 tttattttag cagaggtaac ttttttgact ttgtaacatt actgtaagga tattgaaata 579901 aaaaatagct ggttgatcgt gtataatctt cctagatgtt aacaaacagg gggacgaaat 579961 gttgaagaaa gtcattttag ccgcttttat cttagtagga agtactttgg gagcttttag 580021 tttttcatca gatgccagtg cgaaacatgt gaacggaaat attacttggt ataatggagt 580081 cgggaaaaaa ggctcttcag gtaagaaact tggacattgg gattgtgcga ccaaaatcgg 580141 atttgatgtt cctagaaacg ggacaaaaat cagagcttat gcaaaagcga agcctaaaaa 580201 ggtgattacg gtttataaaa atgatgttgg cagaatgcct aatgcagtgc tggatgttag 580261 ccctaaagcg tttaaagcgc ttggataccc attaagcaaa ggtaaagtag cggggcatta 580321 cagctattaa tgtacatata taatctggaa agcaagaagt cacattcttg ctttttctat 580381 tggtggagat aaaagatgaa aaaaagaatc atattattat tagcagtgat aatagcggca 580441 gctgccgcgg gggttgcgtt ttatgttgca aaggataaag gccatgagaa ggctgctgat 580501 gtttcagtca ataccgaaag cggtgatgag ctgctggttt caattacaga tacggatctg 580561 ctgacaaagt attatgaaaa tgacaaggtg atccatgagg agaagctgac cagctatccg 580621 gcatttgcct tggatcaaaa acagcaggtg ctctattata cgggcaataa tgaacagaat 580681 gaaatgaggc tttttaaatt ggatctgaag tctcataaaa aaacgatgct ttataaaggc 580741 gcggagagtg cggacagttt atttttatca aaggaccgtt caaccatcta tttccgctta 580801 ggaaaagcgg acgaaagcaa ttttcgaatc gccgcttttg atctgaagac gaaaaagtat 580861 aaaaatcttt atcctgccgc taatgatcag gatgacaccg tcagcagctt cttttataac 580921 caaaaaaacg attcatttgc attgcttcat tattctgtag aagaagacta caagaaaaca 580981 gatgaagcaa acgaaaaggg catcgaccct gaaccgacaa cgattcattt tgcggaaggc 581041 cgccaaaata aatttaatga gctgaaaagc ctgaaccaat ttatcagcga tattgctgtt 581101 tctgatgatg ataaacgtat tttattcaca tcatatacgc aaaaaggaac ggagcaaacc 581161 gcttctattc aaatgctcaa tgcggatacg aaaaaatatg aaagcatcat ctcaaatcaa 581221 aaatcattta agctgttaat tgacgcacag cctcagtttt ctaaggatgg gaagaacatt 581281 tattttcttg ccgaagccaa gggggctaaa aagctgaagg acgaaacagg gcgtgaagct 581341 aaggtgcgga cgatttattc ctatagcctt gagaataaga ccttcaaaaa agtatgggaa 581401 aatccgaacg gcatcatcaa cagctttttt gtgattaact aataaaaacc actcggcatg 581461 agctgagtgg cttttttaat ggatgaggtg cagggctaat gatccgagcc atttaaagat 581521 atgaatcaga ggtaccgaca aaaacagaag ttcaacatat gagttcattg caacattcag 581581 ctttttgaac gcagctcttt ttttcaagtc tttttgctgc tggtttgaga tcacgttatc 581641 actcctctta tatccatatt ataccattaa aacagacaaa aaagccctaa acgtttacag 581701 ttttgggctt ctttcttcgt atttggcctc ttgcaatgag aggcttttat tctgaaatat 581761 agaattttgt ctccgttcgg ggtttgtttg cttgcgggag actgcatttg ttatagggaa 581821 gaactagctt gttttcgttt ggctgttgtt ttggagattc actaatgaac ggatgccgtc 581881 gaccatttta cttccgcaca aagggcacaa tggcgtatca ctgctggcga agttttttcg 581941 ggtccagcca ttacagtctt cttttgtgca ttcccaagta ctcacatctt cctttggcag 582001 cggttcttga tttcgtttgt tatagtaaga cataaagtca cttcttccct catgtatttt 582061 actgcacatt tcctattgtc tcatactttt ccctaatctc ctaattcctt tttctttatg 582121 actttccaat aaccccatct aaaaaggaga ggagtgtgct gttaaaagca tctggctctt 582181 ctaaaaacgg gcaatggctg cttttaggaa aggtaacgag tgtcgcgttt ggaatattgc 582241 tgcgcaagtg ttccccagct gctgtagaga aaaatttctt gtcttccccg aagcacagca 582301 atgccggcac attgatgttt tggagggtgc cccggtaatc agcggccgtt tggttaaata 582361 aaatcgtgct agaaatggca gccggctgtt tgaggatttc tgccagcatc cattctgttt 582421 cggtctcggc aggcggttct gcgaacatat tctggatgaa gctttcgtag aaaggcagcg 582481 ggtcagtttg aatggcgtgc atcgctgttt ttaagccgtc aaaatcaaat ggaccatgtt 582541 cccagccctc ccattgatag tccgaagcgg attgatcgat gatcacagcg gcttgaatgt 582601 tatcattccc aaactgattg agataatccc atacgacaaa agcacccatt gaccagccgg 582661 caagaacgac atgatcaagc tccattgcat ttagaaattc ccttatgtca cgggcatatt 582721 gggaaatggt gtggccgtga agcactttgt cagattcgcc gtgtcctcta agatcaagac 582781 gaatacattg ataattggca gaaagcaccg aaaattgttt gtggaaaaat tgtccgctca 582841 tcagcacccc atgtataaac aggatcggcg tcccgctccc gtgtgtttca tagtaaaggc 582901 gtgtctgatc ttctaatatg atgtatggca tgtttctcct cctttagttt ccatcatgag 582961 tatggctggc tgctgttgag ctgatgatgg cagctgtcgc ggctgcctgc tgcgcttgaa 583021 tgactgtttc gatagcggtg tatagtcctg attccatcag cagatttttc tccatatgct 583081 cactgagata gaggctgaca gcaattttaa agttcatttc cttttgccat ttaaaagctt 583141 tttcctggtt taattcgtca gtgatgcaca aaacggtttt gatatctggc tcttccagaa 583201 atgtgaggag agcaaggtct ggataatgat aatcctttgt ttttttgaca gattcagtga 583261 tcgattgata tatctgtttg caagcggaaa caagcatttc gggctctttt tcactttgca 583321 aggccagaat atggctgacc tgatgtaagt actgtccttt tttaaagccg ttggctgcca 583381 gcagttgata gcatgtttcc gccttctgta gcgcctgcaa accttttccg ttttctccaa 583441 gcagtacggc aagcggaaca ttctgagttg aagtgaggaa ataatgattt ttcttcatct 583501 gctgataaac agctagcccc atgttcatct gttctttttg gtttgtcgtt tcagatttgc 583561 cggtgagcaa gatcagagcg gaaaggtatg tgaacatatc ccgcttatac cctagcttca 583621 ccatttcatt gtatacatcg atgaaagtct gaaatgtttg ttttgcctca tgctgaaaat 583681 gaatgtccag aatagatgca acagtaaagc ggtggtgtga attgagtgtt gagaagctgc 583741 cgatgtttga tttgatatag ctgctcaaat cataaaagcg ctgaaaatca aactctcttt 583801 tattcacaat atatgcagaa gaaatgagca ttaatatctg atcgtgtgaa actttccatt 583861 ttaattttgt ttttaattca gcataaatgg aaatgtaatg ctttgttttt tcatgtagat 583921 cgtgtgtgag cataaaaagc agctcctttt gttgttttta cgtaatacga taaatagggc 583981 caaaggtttc ataaagaaaa aacttgcctg ctagaggcaa gtttgtcggg ttatttatgg 584041 ggatcagtta tatccatcgg tctcatcatg tcatagtctt catgctctag aatatggcaa 584101 tgccatacgt atcgtccgct gtacggaccg aatgtcgccg cgattctcag gacttcacct 584161 gcatgcgctt gaatggtgtc tttccagccc ttttcacttg gcggcggcgg gacagccgga 584221 ccggtatagg acaattcccc gctttcttga taacgggcga tatcaaacgg ccgccggtct 584281 aatacacgga aggagactag atgcaggtgg atcggatgtg ttccgcgtgt cgggttgata 584341 atggaccata tttcagttgt gccgactttt ggtgtttctg tgacgggatc gtgccagcgt 584401 ttgttattaa gcagaaggac gggtctgccg tattcgtcct gggtgcctgc cagttttaac 584461 gttctgatgt tttgtattct ttcatgctgt accgaagggt atgaggcgag gtacttcggc 584521 tttctgcttt cgtctttttg tgccaatggt tttgtgactc tgaattgcat gatattcgca 584581 tctgtttcag gattgacgtc accgccgcag cccgcgctgt ttgccaaaat gatcgattct 584641 ccttcatatg ctgtgaagtc aatgatgata tcgtaacgtt cagcaggcgc aaggctgaaa 584701 gaattcagtt taacagatcg cggcaggagc cctccatctg aaccaatctg aataaaatct 584761 ccgccattat cgagtgacag gttataggtt cttgtattgg aggcgttgat gacacggaat 584821 cggtatttcc ttggctcgac ttccaagtat ggccatacct tcccgttgac gagtatggtt 584881 tctccgcaaa aagccggaac gattgaagga ttaggcagtg acggagaagg gttttccggt 584941 gcgctcggat aaaacaaaga accatcctca ttgatcgtgc ggtctgtgat aagaagcggc 585001 acatcgtatt cgtctgaagg cagttttaag cgtttttcct ttgggtcatg aatgatatat 585061 gcaccgacaa gtccggcata gacatttagc ctggtgagcg ccatggcgtg atcgtgatac 585121 cacaatatag ccccgcgctg ctggtttgga taatgataaa cctctctttt gaaataaggt 585181 cctgtttgtt caaagtcttt ggaaaaccaa gcctccggat acccgtcact atcatctggc 585241 gtgacgccgc cgtgtaaatg aacaacagtc tttacctcgg gctcttcatg ctggctgtca 585301 ctgtgatgaa tggtgtgatc aatcggaagg aaatgcgtgg aaggaaggtt attcatccat 585361 tttacatata cgttttcatt tcttttaacc tcaatggtcg gtcccggaaa taagccgttg 585421 tagccccaca ggcgggttgg agggagatcg cgatggagct gatgagtgca ttcctccatg 585481 gtgacttcgt agtatgtttt ttcttttgat tgctgtactg gctttagtgt atctgggatt 585541 gggagagcat ccacaaattt ttcaagtgtc attttcatct gtccttatct aaattttcca 585601 aattggtact atagttaatg acaataagga cgtgatggtt acaaaaaatc ttcgtgctgc 585661 agcccgcccg aagaagaaaa taacaaaatc ctaaacggca ggccgtttag gatttgatca 585721 gcattaaggc aggatatcgg gttgctgctg tgtgactggg ttggcagccg ctttctcgct 585781 caccttgcgt tttctgaaca caaggtaaga aatcagaacg attcccgtga tgacgcctgt 585841 cagcagcagc tcgtctctca tggaatcaat aaacgccatg gacactaaaa ttccgcaaat 585901 ggcgatgatg gtcaagtagg ttaggaaagg gaagagccac attttgatct tcaatgcttc 585961 tgggtttgtt ttttcgagtt ttttccgcat tttcagctgg gaaacggcga tgacaagata 586021 gacgagtaaa gcgattgcgc ctgatgagtt gactaagaat aaaaagacgg tatccggtga 586081 aaaatagttc attacgaccg cgatataaga gaaaaatgtc ccggccacaa tggcttgtac 586141 gggaacgcct tttttgctca atttcataaa acggcgcggc gcttcatttc tttctgcaag 586201 tgaatacagc attctggatg tggtatacaa acctgaattc aggcaagaga gtacggctgt 586261 gaggacgata aagttcataa tctgtgcggc tgcgggcact cctatatgct caagtacagc 586321 gacgaaaggg ctttctaaaa tatttgctga attccatggc aacagcgcca cgacaatggc 586381 gattgagccc acgtaaaaga cgatgatgcg ccatacaacg gatctggtgg cttttgtcac 586441 agattcgatc gggttggatg tttcccctgc tgcaatggca acgatttcag ttcccataaa 586501 agagaagatg acaacgacaa tgccgagcaa tacggagctg atgccctccg ggaaaaatcc 586561 gcctttgcct gtaagattcg aaaaaccgac tggctcactg cccggtgcaa agccaaaaat 586621 aaaggcaaaa ccaacgatta gaaaagcaat gatagtcaca actttaatga gggagaacca 586681 atattcaaac tcaccgaaag acttaacgga gtagacgttt gtcagggtga gcacaatggt 586741 caagatcaaa cttgtcagcc acagcggaat atcatggaac cagtattgaa taatgccagc 586801 accggcaatg gcttcgatcg ctatgacgat cacccagaaa aaccagtaca gccagccgat 586861 tgtaaatcct gcccacggtc cgatggcgtc gtgagcgtat tgagaaaacg atccgctcgt 586921 cgggtttacg gcagacatct caccgagcat tctcataata aaaatcacca ataatccggc 586981 taacgcgtaa gaaacaacgg cacccggacc ggtcgagtga atcactgaac cgctgcctac 587041 aaataggccg gctccgatta caccggcaat cgaaatcatt gtcatatggc gggtctttaa 587101 ttcctttttt aatcctgatt gagactggtt cataagttac ctccttttaa aatgcaatca 587161 ttactgaata ttatgataat tgaaactcta tcataaatat acagtttgtc gaaaattcgt 587221 gtaagaaaat ataccagctt atttcaaatt tgtagtgttt tgtttgcgct ttcagcgaat 587281 gtgtggaaaa aatgtttcgt tttttattcg ctgtgtgatt ttgcgtaata tttacaattc 587341 gatagaatgc gagaagcact ggtgtccttg ggtttgatgg gatttttggc ggagcaaata 587401 aattggatga gagaaaaagt gttccttcgt cactattttt ctgtggcggg tgaatcatgt 587461 ttctgtagac ccactgcgga tcagctttgt aagataataa taggaaaatg tgagcgagag 587521 gaggttttgt atggagagat atgatgaact gaaaaaggga gaatccggag cgctggtcag 587581 cattgccgcg tatctagttc tttccgcaat taaactgatc atcggttatc tttttcactc 587641 ggaagcactt acggcagacg ggttaaataa cacaactgac attattgctt ctgttgctgt 587701 gctgattggc ctgcgcatct ctcaaaagcc tcctgacgaa gatcatccat acggccactt 587761 tcgagcggaa acgattgcat cgcttatcgc atcgtttatt atgatggttg tcggactgca 587821 agtgctgttc agcgccggag aatctatttt ttctgctaaa caagagacgc cagatatgat 587881 tgcggcttgg acggcagcgg gcggggcagt cctgatgctg atcgtttacc ggtacaataa 587941 aaggctggcc aaaaaggtga agagccaggc gctccttgct gcggctgctg ataataaatc 588001 agacgcattc gtcagtatcg gcacatttat cggcattgtg gctgctcaat tccatcttgc 588061 ttggattgat acggtcactg cgtttgtgat cggtctgctt atttgcaaga ccgcatggga 588121 tatctttaaa gagtcatctc actctttgac agatggattc gacataaagg acatttccgc 588181 ttataaacag acaatcgaaa aaatctccgg tgtgagccgt ttaaaagaca taaaagcaag 588241 atacttgggc agtacggttc atgttgatgt ggtggttgag gtatcggcag atttaaatat 588301 tacggaaagc cacgatatag ccaatgaaat tgagcggaga atgaaggagg agcatgcgat 588361 tgattattcg catgttcata tggagccttt agaacaaaaa taatggagct tcctgtcaca 588421 ggaagcttca gcgtgtcgac aaaccctcgc attcgttgtc aggtctgcgc ttcggtgctc 588481 acgaattaga acattcgctc cgctcctatg ctcgtccttc ctagacttca agggttttca 588541 atcacgctga aaagatgaca aaaccctaaa atgaaagcca ttttaggatt ttgtcaacaa 588601 tctggagctt cctgccacag gaagcttttt tgtgtgtttt ggccagcttt attggtaaca 588661 atttgctaga atcgtttttt tatacagatt gctttttgtg gtaaagttag gttacattat 588721 gatgaatttt gtagatgact aggaggaaaa taatggcata tcaagaagac ctgcatcctt 588781 tgctggggaa agcagttgaa catattaata gagtaatggt tggaaaacga gacatcgcca 588841 tactcagctt agcagccctt cttgccaaag ggcatgtgct gcttgaggat gtacccggag 588901 tcggaaaaac gatgatggtc cgcgcgctgg caaagtcaat cggcgccgat ttcaaaagaa 588961 tccaattcac tccggatttg ctgccatctg atgtaacagg ggtatctatc tataatgcga 589021 aaacgatgga atttgaatat cgtcccggcc caattatggg aaatatcgtg ctggcagatg 589081 aaatcaaccg tacctctccg aagacacagt cggctttgct cgaagcgatg gaagagggga 589141 gcgtcacggt agatggccat acgatgcagc ttgccgatcc gttttttgtg atggcaacgc 589201 aaaacccggt cgaatatgaa gggacctatc ctttgccgga agctcagctt gaccgttttt 589261 tattcaaact tcggatgggt tatccgtcct ttaatgaaga gcttgacgtc ttatctcttc 589321 aggaaaaaag ccatccgatt gagacgcttg agccggttat tgcaaaagaa gacttcatct 589381 ttttacagag ggaagtgcaa aatgtccgtg ctgatgacag cattaaggaa tatatcgttg 589441 aaattgtgca gaaaacgaga cagcatcctt ctgttcaatt aggcgtcagt ccgcgcggct 589501 caatcgccct catgaaagcg gcacaggcat acgcgctgct gcatcatcgc gactatgtca 589561 taccggatga tattcaatat ttagctcctt tcacgctgcc gcaccggatg atgcttcatc 589621 ctgaggcaaa atttgaaggg attcaggcag aagcgatcgt aagggagatc atgtcagctg 589681 tgaaggtgcc ggttcaaagg tcggcggtcc gctgatgaat aagaaatggc aatggctcgt 589741 atatggttgg aagctgatta tattaacttt attgacggct gctgtttttt cttatgcgat 589801 gtttcagggc ggctttgtca gctggttttt gttttacgcg tttctccctt ttgtcttgta 589861 tgccgggctg ttggccttgt atccgctccg ttcttttcag gcttcaaggc aaatggataa 589921 aacacaattg catgcggggg acaggctggg cgtaacggtt acgctgagaa gaaagctgcc 589981 atttccgctg atgtatatgg tgattgaaga ttgcctgcca gaaggtatcg agtcattaaa 590041 tcgagacgga gccgcggcca aacggctcgt ttttccttgg tttaaacgga gcatgacgat 590101 gtcgtatgaa ttagctcggg taccgcgcgg agagcatcac tttcattctg tcagggtgcg 590161 aaccggggat gttcttggct tgattgaaaa aacagcattt tttgagctgg atgatacctt 590221 gtttgtttat ccattctatc agcgtttttc ctatcaggtg aatgagaggc atcaggaaga 590281 cggtgtaagc ggttcttctc ctattcatca gcaccattcc tcagtcgcag caagtgtgcg 590341 gaattatcag ccgggagacc ggtttgctgc gttagattgg aagacatctg cacggcggag 590401 ccagctgatg acgaaggaat ttgagccttc tcgcagcaaa aatctgtttc tgctgatgga 590461 ccgtttttcc tcagacgcat tcgaagaggt cgtttcagtg acagcttcga ttcttcattc 590521 tgttttaaaa aacggcgcgg gtgctggtct ggcttccatc gggaaggaaa aaaacatttt 590581 ccctattcag gaaggggatc agcattttaa gcacatgctt cggcatttag ccatcgctca 590641 ttgtgatgcg gcagacccga taagccgata tgcacgggaa gagctgggaa agccatctgt 590701 tcgccaagct gatcaagttg ttgtcacggg acagttaacg gaagatatgc tgcacctcgc 590761 agaaatagga ggcggccggg ttacggtgat actggcaaaa gagaaagatg ctgagctctc 590821 tcaagctgaa aatgtcatga ttgaacgcat gatgaaacgc caaatcagag ttcggatcat 590881 gaggggcggg cgagtttcgc gtgttgttta gaaagagagg tgactggttc acatgccgca 590941 cgatgatcac aagggaagcc gtttgagctt gctgttattt tattttctgg cttttttatt 591001 gctgtgggag tggcttaggc cgcttgacag ttttactgaa acgaaacata caggcttttt 591061 tagtgtcttt atcggcttga cgtttctgct gacttttttc aggatgaggt ggtttgtcac 591121 cgttcctttt tgtgtcatat ttacattgat ctcgatacac atcctgtttt atcaaggatc 591181 tatattcgac ttgagctggg tcagctcttt tttgcaggat gtctatctga atatcacgct 591241 gattcaatca gggcaatgga atgacatgat tccttcattt cggaccctgc tgttttttgt 591301 gctgctgtgg ctgctggtct atctcctgca ttattgggtg atttaccaga gaagaatttt 591361 gtttttcttt ttgatgacag tagcgtatat tacgattctt gataccttta cgccatatga 591421 tgccactttt gccgtaatcc gtatcgtgct gatcggcttc tttatgctgg gccttttata 591481 cttggaacgc attaagctga tggaaagaat cacactgcca aaaacatctg tcctgaaatg 591541 gtttcttcct ttatctgtat tggttttggc tgcaacggga ttcggactcg ccgctccaaa 591601 atcagagccg gcttggcctg atccggtgcc ttttcttaaa aaaatcactc atcaagaccg 591661 cgtgtctgca ggggaaagca aaatcggata cgggaatcat gatgaatcac tcggcggccc 591721 gttccagcag gatgctacac ctgtttttac atggcaggga aaagagcgta cgtatttccg 591781 tgtggaaacg aaggacacgt ataccggaaa aggctggatt gaaacagaca caggcatgtc 591841 gtatcagctt agcaatggaa aagttgaaaa tctgtggttt gaccataagg ttgcgacaga 591901 gcgccgcacc gtccgtgtaa aagtcgataa gcactacggg tataaccatc tgatgtatcc 591961 gattggtgcg gaaaccattc agccaaagca ggctgtctca cttgaaatga acggcaacac 592021 ggagcaaatt tctccgatca gtgaacaagc cggtgaaatc agaaatatgg ggaattatac 592081 agtaacgtac aattccccgg tctataagct ggatgaactg agaaaggtaa aagtgagaaa 592141 aaacagtgag gagtacacat tcagcgatcg ctacatgcag cttccagatt cactgccaga 592201 gcgggtgaga acccttgcga tcaaactgac tcaggatcac gacaatatgt ttgataaggt 592261 gaaagcggtt gaggactatt tagggtcaaa tgcgttcaca tatgaaacag aaaacgtgac 592321 cattccgaag aatgatgaag attatgtcga tcaatttctc tttgaaacga aaatgggtta 592381 ttgtgataac ttttcttccg ccatggtggt gctcttgcgc tcggccggca ttccggcccg 592441 ctgggtaaag ggttatacgt ccggcgaata caaagaagca gggaacaaaa atggcagcat 592501 ttacgaagtg acaaataaca atgcccattc ctgggtagag gtgtatttcc cggaacaggg 592561 ctgggttaca tttgagccga ctaaagggtt tacaaatccg gctcaattta catcttctga 592621 cacaaaagac tctggcagcg atagcagcag ctcgccgaag aaagcaaaag agaaacagaa 592681 agaagagaaa aaacagccgc aaaaagagga aaaacaaaag gaaaagcggg agccagctgt 592741 ttctaaaaag ccgtccgctt cgcatactaa tgccggtgcg ggcttgtatg cagcgcttgc 592801 ggttcttgca gtcctcctgg tggcagctgt attgctgtat gttttccgct cgttatggat 592861 tcctgttttc gccgtgagga aattgaagcg gcgcagtgat cagcacgcgt tttttgaggc 592921 atatggcgcg ctgctgaaac aactgaagag aaaaggactg ccgaaacgag acagtgaaac 592981 gctgcgtgat tatgcaaaac gaattgatga aaaatacgac atagaagaca tgtcaaagct 593041 gacattaagc tatgaaaggg cgctttacag aaatgaagat tcttcggcgc tatggaatga 593101 ttcgagagag ttatgggaaa atttaattaa aagaagatgg tcttgaccgc ttatcgacgt 593161 gttgttagaa ttagtgaata ttatcggagt ctgggagcga gttggcctga ctccggcaaa 593221 cggccttgcc aaagagggcg gagcgagctt catatctgtc ctcgtttttt tctgtgtcaa 593281 aaaacttaga ggagattagg tgacaaccat gacaaagtta gtgaatgaaa tgattcttgt 593341 ccttgatttc ggcagtcagt ataaccagct gattacacgc cgtatccgtg aattcggtgt 593401 ttacagcgag ctgcatccac atacattgac ggctgaagaa attaaaaaaa tgaatccaaa 593461 aggaattatt ttatccggcg gtccaaacag tgtgtatgat gaaaactctt tccgctgtga 593521 cgagaaaatc ttcgagcttg atattcctgt tttgggaatt tgctacggca tgcagctgat 593581 gactcattac cttggcggta aagttgaagc ggcaagccag cgtgaatacg gaaaagcaaa 593641 catccgcatc gaaggcacac ctgatttgtt cagagatctt ccgaatgaac aagtggtttg 593701 gatgagccac ggcgatttgg ttgtagaagt tcctgaaggc ttcactgttg acgcgacaag 593761 ccatcactgc ccgaactcag caatgagcaa agcggacaaa aaatggtatg gcgttcagtt 593821 ccacccggaa gtgcgccact ctgaatacgg caatgatctt ctgaaaaact ttgtattcgg 593881 tgtttgcgaa tgcgaaggcg aatggtcaat ggagaacttt atcgaaatcg aaatgcaaaa 593941 aatccgtgaa acggtcggag acaaacaggt tctttgcgcg ctaagcggcg gcgttgattc 594001 ctctgttgtt gctgttttga ttcataaagc gatcggcgac cagctgactt gtatctttgt 594061 agaccatggt cttctccgta aaggcgaagc tgagggtgtt atgaaaacat tcagcgaagg 594121 ctttaacatg aatgtgatta aagtagacgc aaaagatcga ttcttaaaca aactaaaagg 594181 cgtttctgat cctgagcaaa aacgcaaaat catcggtaat gaattcattt acgtgtttga 594241 tgatgaagcg gacaagctca aaggcatcga ctaccttgca caaggtacgc tttacacaga 594301 tatcatcgag agcggtacag caacggcgca aacgatcaaa tctcaccaca atgtcggcgg 594361 acttcctgaa gacatgcagt ttgagctgat cgagccgtta aatacgctct tcaaagacga 594421 agtgcgcgcg cttggcacag agctcggcat tccggatgaa atcgtatggc gtcagccgtt 594481 cccaggaccg ggactcggaa tccgcgttct tggcgaagta acagaagaaa aacttgaaat 594541 cgttcgtgaa tcagatgcaa tcttgcgtga agaaattgca aatcacggct tagagcgtga 594601 tatctggcaa tacttcactg ttcttcctga catccgcagc gttggtgtta tgggtgacgc 594661 aagaacatat gattacacaa tcggaatccg cgccgttaca tcaatcgacg gcatgacatc 594721 tgactgggcg cgtatcccgt gggatgtgct tgaagtcatt tcgacacgta tcgtaaacga 594781 agtgaagcac attaaccgcg tggtgtatga tattacaagt aagccgcctg cgacgattga 594841 gtgggaataa gaatcaatta atggaaacca tctttttggc aattttgccg ggaagatggt 594901 tttatttgtt tattacgaac aaaatccgat tttgcgcgac tattgttcgc tttttgtatt 594961 gttttttcaa aatgaacttg gtacaataga cacagaaatc aaataagatg aattcgtata 595021 atcgcgggaa tatggctcgc aagtctctac caagctaccg taaatggctt gactacgtaa 595081 acatttcttt cgtttgatat aaataaaaca cggttattta ttcaaactga aatccgtctg 595141 tagtcaagcg tcccaaaatg tattgggacg ttttttattt ggcgttttca ggacagaata 595201 aatagcaaag agtgaaggga gtcaaatagc ttgaaaacgt tttttcagtt tgatgagctg 595261 ggcaccagct atcgcaatga aatcattggc ggattaacga cttttttatc tatggcatat 595321 attttgttcg tcaatccgat tacgcttgct ttggagagcg tgaaagattt tccggaggcg 595381 ctgagaattg accagggtgc ggtctttacg gcgacagcgc tggcgtctgc agcaggctgt 595441 atcttaatgg gattaatagc gagatatccg attgccatcg cgccgggtat ggggctgaac 595501 gcgttttttg cgttttctgt tgtccttggt atgggtattt catggcaggc agctttgtcc 595561 ggtgttttta tttcaggtct tattttcgtt gctctttctt taacaggttt tcgtgaaaaa 595621 atcatcaacg ccattccgcc tgagctgaaa ttggcagtcg gtgcggggat cggcctgttt 595681 attacatttg ttggattaca aggttcagga atcattacag cgaatccttc tacgctcgtc 595741 acgatcggaa acattcacag cggtcctgtg ctgttaacga ttttcggtgt gattgtcacg 595801 gttattttaa tggtgcttcg cgtgaacgca ggcgtgttta tcgggatgct attaacagcg 595861 gtagccggca tgattttcgg tttggttccg gttccgactc aaattatcgg cagtgtgcca 595921 agccttgcgc cgactttcgg acaagcgtgg attcacctcc cggatatttt ctctgtacaa 595981 atgctgatcg ttattttaac attcttgttt gtcggatttt ttgatacagc tggtacactt 596041 gttgctgtgg caacacaagc tggtttaatg aaggaaaaca aattgccgcg tgcgggccgt 596101 gcgcttttag ctgattcatc ttctattgtg atcggtgccg tgcttggtac gtctacaaca 596161 acttcttacg tggaatcaag ctcaggtgtc gctgcgggtg cccggtcagg atttgccgca 596221 attgtaacag ggattctctt tttactggct acgtttttct cgccgctcct atcagtcgtt 596281 acgtcaaatg taacagcgcc ggcgcttatt attgttggtg cattgatggt ggcgccgctt 596341 ggcaaaatcg cttgggataa gttcgaagtg gccgttcctg ctttccttac catgatcatg 596401 atgccgttaa cgtacagcat cgcgactggt attgccatcg gatttatttt ctatccgatt 596461 acaatggtgt gcaaaggaaa agcaaaagag gttcatccaa tcatgtacgg gctgtttgtc 596521 gtatttatcc tgtactttat cttcttaaaa taaggaatga aaaaccagct gcactggcag 596581 ctggtttttt tgttgcaaaa gataaaacca tttcatacga tataccgtca tgtagatgtg 596641 ccgccatgct ttacttaaat ggaaatgact tgactgttca ggaaggcttc ggtaccttat 596701 ataagtgttt tattttcttg ctgaatggta ttccgccgta tttttttgat aggagttgct 596761 gacatgacgg aagaaagaaa agaaacgttt gaagaagaaa ttaaccagag tgaaagaata 596821 gatgcagatg aagaaccgct atcgagaatg tccagaaagg cgagccggca aagcaagcag 596881 aagcaaaaac aaaagcagaa accgcgccag gaacgcggtg aatcaactgt taaagacaag 596941 cttgcgtctg tttgggcagc catcaacaga tattgcggtt ttgcgttctc gattttaaaa 597001 tctccggcga aaactgtcgt aacggatggt ttttctcatt ataagtacgg tctgatttca 597061 atgcttatat tcagtatcat tttttcaatt gggaattggt ttcagttaaa ggcaagctgg 597121 aatcggccgc tcggtttcgg agaacgccat catgctttct atgacgggtt tttagttgtt 597181 cttgtgtatt tgctgatctt tttcgcggta atggtctttg ctatatgggc tgtctcccgc 597241 tatatgatga agcagaaggt gacgttcaga gaagcggctg ccgtattggg ttcattgctt 597301 gtacccgtaa ttgctgtttc aatcctttgg ctgatctttg cgatcgtaaa tatcccaatg 597361 ctgacagtac tgtttacggt gctgatcttg ttttccatct tttttatcat cgcgctgtat 597421 gtacagcgtg tgtaccaggc ggcacaagat gcaccaattg attatatcta ttgtgtattt 597481 gcagtagttg cgatagcgct gctgtttacg gcagtgactt ggccgtttat ttctgaatat 597541 attacggcgt cgttgattcc gctttaatga aaaaaccggc taatcctagc cggttttttt 597601 atgtcacact ttttacaaat atatctaaaa aacatagttg atttgtagga ttaacccgtg 597661 tatgatgggg aaaatgctga aaacgtccag cgcaaaaacc tttatgttta aggaggatga 597721 tggacatggc tgatgtactt cgccgagcaa ttaaccaaaa gaagcaattt ttaaaaacca 597781 aattactgct ctcggaattt tatcaaggaa gaggggaaca gcttgctgac tacacgctga 597841 gtgagcttga gaaagaatac aagtcccttc agaaaatgaa aaaagagatc tgacaataga 597901 tataaagagg tgagtctgct gaaaagcggg cttttttgtt ttgattttga aaaggcgaga 597961 aagagggtaa actactactg ttcaacacat aaaagcgtgt cgaaatattt tgcttaagct 598021 tacgggcgaa gctgattgta aacggctcat ttctctagta gaatatgaat gctttgtgca 598081 agctgaagag tagggggatg aataaaatga tgcaaaccat cttatcaaat gggatagcca 598141 tggttctcat aattctcatt attaatattg tctatgtgtc attttttacg ataagaatga 598201 ttttaacgct gaaaggacag cgttatttag cggccggcat cagtacgatt gaaatactgg 598261 tttatgtgac aggactgagt ctggtgctcg ataacttaga ccagattcaa aatgtgatcg 598321 cgtacgcgct cggttacggt cttggcgtaa ttgtcggcat gaaaatagaa gaaaaattgg 598381 cgcttggcta tattatggtc aatgtgatta cgaaggagct cgatcttgat cttccgaagc 598441 agctccgtga aaaaggctac ggcgtgacaa actgggtggc aggcgggctt gaaggcgacc 598501 gcacagccct tcagatcctg acgccgagaa gatatgaact ccagctatat gatacgatta 598561 aaacacttga ttcaaaagcc tttattattg cgtacgaacc aaaaacaatc cacggcggct 598621 tctgggtcaa agcggtgaag aagaggagaa ttaaagaata atggcaaagc cgaagaagaa 598681 aaagtttgaa gtgacagagc agcaaacgat tgatgcggtg cttcagcaaa tgaaagaaga 598741 aggatatctg cctgtaaggc gaatggaaga gcctattttt atggaaaaaa aggaaaatgg 598801 gtcaattcag atcgttccgt gcgggaaaaa aatcgtattt gaagggaaat tgatctaaaa 598861 cacgaacatt agtagaatga atttttgtat cgttcgataa tatcgttgac attatccatg 598921 tccgttgtta agataaacat gaaatcaaaa cacgacctca tataatcttg ggaatatggc 598981 ccataagttt ctacccggca accgtaaatt gccggactat gcaggaaagt gatcgataaa 599041 actgacatgg atatatcgca gaagcgaacg actgacgata catgtaccat gcccggtttg 599101 tattgcttcc tcataagtgc aatgcagagc gggtattttt tattttctga aaacaaaagc 599161 attagaaggt ggggaacaga atgcagccgc tagtaggaat catcatggga agcacttccg 599221 attgggagac aatgaaacac gcatgcgaca tacttgacga actcaatgtt ccgtacgaaa 599281 aaaaggtcgt ttccgctcac cggacgcctg atttcatgtt tgaatatgct gaaactgcta 599341 gagaaagagg catcaaggtg attattgccg gtgccggagg agcggcgcat ctgccaggga 599401 tgacggctgc gaaaacaaca ctgccagtca ttggagttcc ggttcagtcc aaggcgctga 599461 acggaatgga ttcacttctt tccatcgtcc aaatgcctgg aggcgtgcct gttgcgacaa 599521 catccatcgg caaagcgggt gctgtgaacg caggcctgtt agcggcgcaa attttgtcag 599581 catttgacga agaccttgcc cgtaagctgg atgagagaag agaaaataca aaacagacag 599641 tgttagaaag cagtgatcag cttgtctaaa caaatcatct atccgggagc tgtaatcggc 599701 attatcggcg gcggccagct tgggaaaatg atggctgtgt ccgccaaaca aatggggtat 599761 aaagtcgcgg tcgttgatcc ggtgaaagat tcgccgtgcg ggcaggttgc ggatgtcgaa 599821 attaccgctc attataatga ccgtgaagcg attcgaaaat tggctgaaat cagcgatatc 599881 atcacatatg agtttgaaaa catcgactat gatgcgctgc attggctaaa agatcatgcg 599941 tatctcccgc aaggaagtga gctgctgctt attacccaaa accgtgaaac agagaaaaaa 600001 gcaattcaat ccgcgggctg tgaagtcgca ccgtacagca tcgtcaaaac aaagaatgaa 600061 ttgaaacagg cagtacagga gctcaggctt ccggcagtgc tgaaaacatg ccgcggcggg 600121 tacgacggca aaggccaatt tgtgataaaa gaagaggcgc aaatggagca ggcagccgct 600181 ctgttagaac acggaacttg cattcttgaa agctgggttt cttttaaaat ggaactgtcg 600241 gtgatcgtcg ttagatcggt aaacggtgaa atttcaacat ttccgacagc tgaaaacatt 600301 caccacaaca atattctttt ccaaagcatc gtgcccgcac gggtagagaa agggattcag 600361 cagaaggctg ctgatctcgc agttaagctt gcagatgagc ttaaccttgt cggaccgctt 600421 gctgttgaga tgttcctgac agaggacgga gagcttttgg tcaatgaact ggcgccaaga 600481 ccgcacaatt cagggcatta tacgctggac ctttgcgaga cgagccagtt tgagcagcat 600541 atcagagcgg tatgcgggct tccgcttggg aagacagatt tgctgaagcc gggcatgatg 600601 gtgaatcttc tcggcgatga agtgaagctt gttgaggaag acccggagct tttaaaagag 600661 gcaaagctat atatatacgg aaaacatgaa atcaaaaaag gccgcaaaat ggggcatatt 600721 acatttatga agcagcctga agacgaatgg attcaggaga tcacaaataa atggatgaat 600781 agagacggag gacaagcaga atgatcgaac gttattcaag acctgaaatg tccgcgattt 600841 ggacggatga aaacagattt caagcatggt tagaggttga aattcttgcc tgtgaagcgt 600901 gggcggagct tggcgtcatt ccgaaagaag atgtaaaggt tatgcgcgaa aacgcgtcat 600961 ttgacatcaa ccgcatttta gaaatcgaaa aggacacgcg ccatgacgtt gtcgctttta 601021 cgcgcgctgt atccgaatca ctgggcgaag aaagaaaatg ggtgcattac ggcttaacgt 601081 caactgacgt tgttgatacg gctctttcct acttattaaa acaggcaaac gatattttgc 601141 tcaaggatct tgagagattt gttgacatta taaaagaaaa agcgaaagaa cataaataca 601201 cagtcatgat ggggcgcaca cacggcgtac acgctgagcc tacaacattc ggcttaaaac 601261 ttgcgctttg gcatgaagaa atgaaacgta atcttgagcg cttcaaacaa gcgaaagcag 601321 gcatcgaggt tggaaagatt tccggtgctg tcggcacata tgcgaacatt gatccatttg 601381 ttgaacaata tgtctgtgag aagctcggat tgaaagcagc accgatttcc actcaaaccc 601441 ttcagcgtga ccgccatgct gactatatgg caacacttgc tttgatcgcg acaagcatcg 601501 agaaattcgc tgtggaaatc cgcggactgc aaaagagtga aacacgtgaa gtagaggaat 601561 ttttcgcgaa agggcaaaag ggttcatctg caatgccgca taaacgaaat ccgattggct 601621 ctgaaaacat gacaggcatg gcgcgcgtga tccgcggcta catgatgaca gcttacgaaa 601681 atgttccatt atggcatgag cgcgatattt ctcattcttc agcagaacga attattcttc 601741 cggatgcgac aattgcgctg aactacatgc tgaaccgctt ctccaacatc gtgaagaact 601801 taacggtctt cccggaaaac atgaagcgca acatggaccg cactctcggc cttatctatt 601861 ctcagcgtgt gctccttgct ttgattgaca caggcctgac tcgtgaagaa gcctatgata 601921 cagttcagcc gaaagcaatg gaagcgtggg aaaaacaagt gccgttccgc gagcttgtgg 601981 aagcggaaga gaaaatcacg tcacgtcttt ctccagaaaa aattgctgac tgctttgatt 602041 acaattacca tctgaaaaat gttgatctga tctttgaacg tttaggttta gcatagaaga 602101 agcttttagc ggcttcttct aagccgccgc agtttgaaaa ttcccaacat tcgggttagg 602161 aggccttccg tgaatattgt gaagaatgaa cttttatacg aaggaaaagc aaaaaagatc 602221 tacaaaaccg atgacgaaaa cacgctgtat gtcgtgtata aagactccgc cactgccttt 602281 aacggcgaga aaaaagcaga aatcagcgga aaagggcgct taaataatga aatttcaagc 602341 ctcattttca aacaccttca tgctaagggc attaacaatc attttatcga gcgcatttcg 602401 gaaacggagc agctcattaa aaaggtaacg attgtgccgc ttgaagtcgt ggtaagaaat 602461 gttgtggcag gaagcatgtc caaacgtctc ggcattccag aaggcacgga gcttgagcag 602521 ccgattatcg agttttacta caaggatgac gcgctgggtg atccgctcat cacagaagat 602581 catatttggc ttttgaaggc ggcgactcct gagcaggtag aaaccattaa gtccattaca 602641 acaatagtaa atgaagagct tcaaagcatc ttcgacgatt gtcatgtcag attaatagat 602701 ttcaagcttg aattcggttt agatgcagaa gggcaagtgc ttttggcgga tgaaatatct 602761 cctgacacat gccgcttgtg ggataaagaa acgaacgaaa agctggacaa agatttattc 602821 agacgcaatc tgggaagctt aaccgacgca tacgaagaga ttttcaatag actgggaggc 602881 attcatcatg tataaagtaa aagtttatgt cagcttaaaa gaaagtgtac tagatccaca 602941 agggagcgct gtccagcatg ccttgcacag tatgacttac aacgaagttc aagatgtgcg 603001 catcgggaaa tacatggagc ttaccattga aaaatctgac cgtgatcttg acgtgctagt 603061 gaaagaaatg tgcgaaaaac ttcttgcgaa cacagtgatt gaagattata gatatgaggt 603121 tgaggaggta gtcgcacagt gaaatttgcg gtgattgtgt tacccggctc caactgtgat 603181 atcgatatgt atcatgctgt aaaggatgag ctcggccatg aagtggaata cgtctggcat 603241 gaggaaacaa gccttgacgg cttcgacggc gtgttaattc cgggaggatt ttcttacggc 603301 gattacttaa gatgcggcgc catcgcccga tttgcgaata ttatgccagc tgtcaaacaa 603361 gcagcggctg aaggaaaacc tgttcttggc gtctgtaacg gattccagat tttacaggag 603421 cttgggctgc tgccaggcgc aatgagacgc aacaaagatc tgaagttcat ttgccgtccg 603481 gttgaattga ttgttcagaa cgacgaaacc ttattcacag cttcctacga aaagggagaa 603541 tcgattacaa tcccggttgc ccatggtgaa gggaatttct actgtgatga cgagacgctt 603601 gctacattaa aggaaaacaa tcaaattgct ttcacatacg gctctaatat taatggaagt 603661 gtcagcgaca ttgccggtgt cgtgaatgag aaaggcaatg tattaggcat gatgcctcac 603721 cctgagcgcg cggtcgatga actgcttgga agcgccgacg gtcttaaatt gttccagtct 603781 atcgtgaaaa attggaggga aactcatgtc actactgctt gaaccaagta aagaacaaat 603841 aaaagaagag aaactgtatc agcaaatggg tgtcagtgat gatgagtttg cattgataga 603901 atccattctt ggaagattgc cgaactacac agaaatcgga attttttctg tcatgtggtc 603961 tgagcattgc agctataaaa actcaaagcc gattctgcgt aaattcccga caagcggcga 604021 gcgtgtgctg caggggccgg gggaaggcgc cggaatcgtt gatatcggtg ataaccaagc 604081 ggttgtgttc aaaattgaat cacataacca cccatcagct ctcgagcctt accaaggcgc 604141 tgcgactggc gtaggcggaa ttatccgtga tgtattctca atgggtgcac gcccaatcgc 604201 tgtattgaac tctcttcgat ttggtgaact gacttcaccc cgcgtgaagt acttgtttga 604261 agaagtagta gcgggtatcg ccggatacgg caactgtatc ggcatcccga cagtcggcgg 604321 agaagtgcag tttgacagca gctatgaagg aaatccgctc gtcaacgcaa tgtgcgtcgg 604381 tttaatcaac catgaagaca tcaaaaaagg ccaggcaaag ggtgtcggca acacagtaat 604441 gtacgtagga gcgaaaacag ggcgtgacgg catccacggc gctacgtttg cttctgaaga 604501 aatgtcagac tcgtctgaag aaaagcgttc tgctgtccaa gtcggcgatc cgtttatgga 604561 gaagcttttg cttgaagcat gtctggaagt catccaatgc gacgccttag tcggcattca 604621 ggatatggga gctgccggtt taacaagctc aagtgcagaa atggcaagta aagccggttc 604681 tggcattgaa atgaatcttg acctgattcc tcagcgcgaa acaggcatga ccgcgtatga 604741 aatgatgctt tctgaatcac aagaacggat gcttttggtt attgagcgcg gacgtgagca 604801 ggaaatcatc gatatttttg acaagtatga tcttgaagcg gtttctgtcg gacatgtgac 604861 agatgataaa atgcttcgcc tgacacataa aggagaggtt gtgtgcgagc tgcctgttga 604921 tgccttggca gaagaagcac cggtttacca taagccttct caagagcctg cttactatcg 604981 cgagtttttg gaaacagacg ttccggctcc gcaaattgaa gatgcgaatg aaatgctgaa 605041 ggcccttctt cagcagccga cgattgcgag taaagagtgg gtttatgatc agtatgacta 605101 catggtgcgc acgaatacag ttgtcgctcc tgggtctgat gctggtgttc tcagaatccg 605161 cggaacgaaa aaggcgctgg cgatgacgac agactgtaac gcgcgttatc tctatcttga 605221 tcctgaagtc ggagggaaaa ttgctgtcgc tgaagcagcg cgcaacatca tttgctcagg 605281 cgcagaaccg cttgcggtga cagataacct taacttcgga aaccctgaga agccggaaat 605341 cttctggcag atcgaaaaag cggcagacgg cataagcgaa gcgtgcaatg ttctcagcac 605401 tccggttatc ggcggtaacg tatcgcttta taacgaatca aacggcacgg cgatctatcc 605461 gacaccagtt atcggcatgg tcggcctaat tgaagataca gcgcacatta caacacagca 605521 tttcaaacaa gcaggagatc tcgtatacgt gatcggcgaa acaaaaccag agtttgccgg 605581 aagcgagctg caaaaaatga cagaaggccg tatttacggc aaagcgccgc aaatcgatct 605641 tgatgtagag ctgtctcgtc aaaaagcact gcttgacgcg attaaaaaag gcttcgttca 605701 atctgcgcat gatgtgtctg aaggcggctt aggcgtagcg attgcggaaa gtgtcatgac 605761 gacggaaaac cttggcgcta atgtgactgt agaaggggaa gcggcgttat tattctctga 605821 atctcaatct cgcttcgtcg tttcagtgaa aaaagaacat caagctgcgt ttgaagcaac 605881 tgtcaaagat gcagttcata ttggtgaggt aacagctgac ggaattctgg cgattcaaaa 605941 ccaagacgga caacaaatga ttcatgcgca aacgaaagag cttgaacgcg tatggaaagg 606001 agctatccca tgcttgctga aatcaaaggc ttaaatgaag aatgcggcgt ttttgggatt 606061 tggggacatg aagaagcccc gcaaatcacg tattacggtc tccacagcct tcagcaccga 606121 ggacaggagg gtgctggcat cgtagcgact gacggtgaaa agctgacggc tcacaaaggc 606181 caaggtctga tcactgaagt atttcaaaac ggcgaactca gcaaagtaaa gggaaaaggc 606241 gctatcgggc acgttcggta cgcaacggct ggaggcggcg gatacgaaaa tgttcagccg 606301 ctcctcttcc gttcccaaaa caacggcagc ctggcgcttg ctcataacgg aaatcttgtc 606361 aacgccactc agctgaagca gcagctcgaa aatcaaggga gcatctttca aacctcttcg 606421 gatacagagg ttttggctca cctgatcaaa agaagcggac acttcacgct gaaggatcaa 606481 attaaaaact cgctttctat gctgaaaggc gcctacgcgt tcctgatcat gaccgaaaca 606541 gaaatgattg tcgcacttga tccaaacggg ctgagaccgc tatccatcgg catgatgggc 606601 gacgcttatg tggtcgcatc agaaacatgc gcatttgacg tcgtcggcgc aacgtacctt 606661 cgcgaggtag agccgggaga aatgctgatc attaatgatg aaggcatgaa atcagagcgt 606721 ttttccatga atatcaatcg ttccatttgc agcatggagt acatttattt ctccagacca 606781 gacagcaata ttgacggtat taatgtgcac agtgcccgta aaaaccttgg gaaaatgctg 606841 gctcaggaat ccgcagttga agctgacgtc gtaaccgggg ttccggattc cagtatttca 606901 gcggcgatcg gctatgcaga ggcaacaggc attccgtatg agcttggctt aatcaaaaac 606961 cgttatgttg gcagaacgtt tattcagccg tcccaggctc tgcgtgagca aggcgtcaga 607021 atgaagctgt ctgcggtgcg cggggttgta gaaggcaaac gcgtcgtgat ggtggatgac 607081 tctatcgtgc gaggaacaac tagccgccgg attgtcacga tgctaagaga agcgggtgcg 607141 acagaggtgc atgtgaaaat cagttcaccg ccgatcgctc atccgtgctt ttacggcatt 607201 gacacttcca cacatgaaga actgatcgcg tcttcgcatt ctgttgaaga aatccgtcag 607261 gaaatcggag ccgataccct ctcatttttg agtgtggaag ggctgctgaa aggcatcggc 607321 agaaaatacg atgactcgaa ttgcggacag tgtctcgctt gctttacagg aaaatatccg 607381 actgaaattt accaggatac agtgcttcct cacgtaaaag aagcagtatt aaccaaataa 607441 aacttgaaaa atgacataaa ggcagcgcag ttcggctgcc tttctctttc tgccctcgtt 607501 cggggagata ttttgaaaag cgccttaaag gagtgaatag gatgtctgaa gcatataaaa 607561 acgcaggagt tgacatcgaa gccggatatg aagctgtaaa acgaatgaaa aaacacgtgg 607621 agcgcacgaa acggcttggc gttatgggca gccttggcgg ttttggcggc atgtttgacc 607681 tgtctgagct ttcttatcaa aaaccagttc tcatttcggg aacggacggt gtcggcacaa 607741 aattaaagct cgctttttcc atggataagc atgacacgat tggcgtggat gctgttgcaa 607801 tgtgtgtcaa tgacgtgctg gcacaaggtg cagagccgct gtttttcctc gattatttag 607861 cggttggcaa agcggaccca gtgaaaattg aacagattgt acaaggtgtt gcggaaggct 607921 gtgagcagtc aggttcagcc ttagtcggcg gtgaaacggc tgaaatgccg gggctctata 607981 cagctgatga atacgatatt gccggtttct cagtcggagt ggcagaaaag gacgaaatcg 608041 tgactggaga aaaaattgaa gagggccatc tgttgatcgg cctcagctcc agcggccttc 608101 acagcaacgg cttttccctt gtcagaaaag tgcttctgga tgatgcggag ctggacctcg 608161 atacaacata tgagccgttt gaacgcccgc ttggcgagga attgcttgaa ccgacaagga 608221 tttacgtgaa gcctgtgctt gccgcggtca aaagcggaaa aatcgacggc atggcgcacg 608281 tgacaggcgg aggatttatt gaaaatattc cgcgtatgct tccggaaggc ttaagtgcgg 608341 aaattgatca tggctcatgg ccgatcccgc cgattttttc tttcttgcaa gagtacggca 608401 agctaaagga agaagacatg ttcaacgtct ttaatatggg tatcggtttt gttttggcag 608461 tcaaagaaga gcatctgaca gatgtgatcg gaacgcttga aagccatggc gaaaaagcct 608521 atttaatcgg gcgtgtgaaa aaaggtgaag gcgtcacatt cggcggtgcg gcactttcat 608581 gaaaaagttt gcggtatttg catcaggaaa cggttcaaac ttcgaagcca tcgtcacgcg 608641 tttgaaggag gagaactggg atgcgtcagc agcgctcctc gtttgcgaca aaccgcaggc 608701 gaaagtcatc gaacgggcgg aagcattcca cattccatcc ttcgcatttg agccgaagtc 608761 ttatgaaaac aaggctgcat ttgaacaagc catcattgaa cagcttcgtc ttcacgaggt 608821 tgaattgatt gctcttgccg gctatatgag gctgatcggt gatacgctcc ttcaagcata 608881 tgggggaaaa atcattaaca ttcacccatc gcttcttccg gcgtttcctg gaatcgacgc 608941 agtcggacag gcgttccggg cgggtgtgaa ggtggccgga atcaccgtgc attatgtcga 609001 tgaaggaatg gatacaggtc cgatcatcgc tcaaaaggca atcgaaattg atgaacatga 609061 tacattggaa acaatcgaac agcgaattca caagcttgag cataaatggt atccgagtgt 609121 gattaaacag ctattaggat taaataacag aggtgaaaag gcatgaccat taaacgtgca 609181 ttaatcagtg tttcagataa aacaaatctc gttcctttcg taaaagaact gacagagctt 609241 ggcgttgaag tcatctccac aggcggaacg aaaaagcttc ttcaagaaaa cggtgtggat 609301 gtgatcggaa tttctgaagt gacaggcttt cctgaaatta tggacggccg gttaaaaacc 609361 ctacacccga atattcacgg cggccttctg gcggttcgcg gcaatgaaga gcatatggcg 609421 cagatcaatg aacacgggat tcagccgatt gacctcgttg tcgtcaacct ctatccattt 609481 aaagaaacga tttctaaaga agacgtcacg tatgaagaag cgatcgaaaa tatcgacatc 609541 ggcggacctg gcatgctgcg cgcggcatca aagaaccatc aggatgtcac ggttatcgtc 609601 gatccggccg attacagccc agtgctaaat caaatcaaag aagaaggcag cgtatctctt 609661 cagaaaaaac gcgagctcgc ggcaaaagta ttccgtcata ctgcggcata tgatgcactg 609721 atcgctgact atctgacaaa tgttgtcggt gaaaaagaac cagagcaatt cactgtgaca 609781 tttgagaaaa aacaatcgct tcgctatgga gaaaacccgc atcaggaagc aactttctat 609841 caaacagctc ttcctgtcaa aggctccatt gcgcaagcag aacagcttca cggaaaagag 609901 ctttcttaca acaacattaa agacgcggat gctgcagttc aaatcgttcg tgaattcact 609961 gaaccggctg ctgttgctgt gaagcatatg aacccgtgcg gcgtgggaac aggaaaaacg 610021 atcgcagaag cgtttgacag agcgtttgaa gcggataaaa catctatctt cggcggcatt 610081 atcgcgctga accgtgaagt ggacaaggca actgccgaag cgcttcacaa cattttctta 610141 gaaatcatca ttgcgccttc attcagccaa gaagcgctcg acgtcctgac tgcgaagaaa 610201 aatctccgtc tgctgacgct tgacgtatcc gccgctgttc aaaaggaaaa acagctgaca 610261 tccgttcaag gcgggctgct gattcaagat ttagatatgc acggcttcga tgatgctgag 610321 attagcattc cgacaaaaag agagccgaac gagcaagagt gggaagactt gaagcttgct 610381 tggaaagtcg tgaagcatgt gaaatcaaat gcgattgttc tcgcgaagga caacatgaca 610441 gtcggcgtgg gagcaggcca aatgaaccgc gtcggatcgg caaaaatcgc aatcgagcaa 610501 gcaggggaaa aagcgaaggg cagcgcgctc ggttcggatg catatttccc aatgccagat 610561 actgtcgaag aagcggcaaa agcgggcgtt acagccatca ttcagccagg cggatcgatc 610621 cgagatgagg attccatcaa aaaagcggat gaatacggca ttgccatggt attcaccggc 610681 atcagacact tcaaacatta aggggatgaa aacgacgtga atgtattaat tatcggtaaa 610741 ggcggaagag aacatacgct ggcgtggaag gcagcgcaaa gcagcctcgt cgagaatgta 610801 tttgccgctc ccggaaatga cggcatggca gcttccgctc agcttgtaaa cattgaggaa 610861 agcgaccacg cagggcttgt ctcatttgca aaacaaaatc aggtcggcct gaccattgtc 610921 ggccctgagg ttcctttaat tgaaggtctg gtggatgaat tcgaaaaagc gggcttacat 610981 gtgttcggtc cgtcaaaagc tgcggcgatc atcgaaggaa gcaaacagtt cgctaaggat 611041 ttaatgaaga aatacgacat tccgaccgca gaatacgaga cgtttacatc ctttgatgag 611101 gcgaaggcat atgtgcagga aaaaggtgct ccgattgtga taaaagcaga tggacttgca 611161 gctggaaaag gcgttactgt ggctatgaca gaggaagaag caattgcgtg cttgcatgac 611221 tttcttgaag atgaaaagtt cggtgatgcg agcgcgtccg ttgtcattga agaatatctt 611281 tctggtgaag aattttctct aatggccttt gtcaaagggg aaaaggtgta tccgatggtg 611341 attgcccagg atcacaagcg ggcgtttgac ggagacaaag gcccgaatac aggcggcatg 611401 ggcgcctact cgccagttcc gcaaatttcg gaagaaacgg tccgccatgc tgtagaaacg 611461 atcgttaagc cggctgcaaa agcaatggta caagaaggcc gttccttcac tggcgttttg 611521 tacgctggat tgatgcttac tgaaaacggc tcgaaggtca ttgaatttaa tgcccgtttc 611581 ggcgatccgg aaacacaggt cgtgcttccg cgcatggaat ctgatctggt acaggtgctt 611641 cttgatcttt tagatgataa ggaagttgac ttaagatgga aggataccgc ggcagtgagt 611701 gttgtgcttg catcagaagg gtatccggaa agctatgcaa aaggcacgcc gatcggcagc 611761 cttgcagcag aaactgagca ggtcgtggtc ttccatgccg gaacgaaagc agaaggtgga 611821 gagttcgtta caaacggggg gcgcgtcgcc aatgtgacgg cttttgatga aacgtttgaa 611881 gcggctagag accgagtgta caaagcggtt gatgaaattt tcaaaccggg actctttttc 611941 agaaaagaca ttggggcacg cgctttaaag gctgcccaaa aataagtgag gaaaacccgc 612001 agaatagctg cgggtttttt gttatcaaaa agcgggatgg cagctagaag aagaaagcac 612061 aacgagcgtg gttggttttc catgggccat cgaggtgtca ataaaatcct caagcgtatg 612121 taccgattca gtcacgacct ttgtcacata gctgtacatc cccgtgatgc ggtggttttc 612181 tgctacatca ggatgcgatg ttgcaaaggc ggcgtagtgc ttgcagcttt tcggctccat 612241 gagaataaaa gcggtgacat gcttgtttag tttttcgtaa cagatattcg cgctgtagcc 612301 ggtaatcact cctttgtctt ccagcttcct gacacgctcc gccgcgcttg gcgagctgag 612361 tccgacaagc tttcccagct caaccatcgt taatctgccg tttcgctgca aatgcgagag 612421 aatctgaagg tctgtatcgt ccatttgtct ggctccttta catatttagg cgaatgaatg 612481 aaaattcctt tgatcgtaag gtaatgctgt tgatttaact tcattgtagc atatggatgc 612541 cgtcttattt tttctataat aaagccatca atcagagagg gggcatcatg ttgccagaat 612601 tgcagcgctc tattacttgg atacaaggga cggcgttaac gattggggcg gttttaggat 612661 gcgggatatt aatcctgccg tctgtcaccg cggacacggc cggccccgct tctttatttg 612721 tttgggtgtt catgtccttc ttatcctttt ttcttgtcgg cacgctggcc cggcttgtga 612781 aaatagcgcc tagcgcggga ggaatcacgg cttatgtgca gctggccttt cagaaaaaag 612841 ccggggctat tttgggctgg atcatgttag ggtccgttcc gatcggcgtt cccatcatcg 612901 ctttgactgg cgcgcattac gtcagttaca tcacagaggc ggccgattgg cagattacat 612961 tgattgctgg ttgcatgctg gctatatcta ttttgcttca tatgagaggg attcaactat 613021 cagcaaacat tagtacactc gttatatgtg tcatcgtatt tctgcttgtc acttctattg 613081 ctgtgtcatt gccacacgtc acgatagcag aattcaagcc gtttcttccg catggctggt 613141 ctgccgctgg atctgtttct gttatgattt ttttctcttt tgtaggctgg gaaatgatta 613201 ccccgttggc tgaggaattt catcgtcctg aaaaagatgt cccgctcagc ttgtttttgg 613261 cagcgtcttg tgtggcgggg ctgtatatca tgctgtcatt tgtgaccgtg ggtactcatt 613321 catatggaga gaatggagaa attgcatcgc ttgccatgct catttcaaaa ggagcaggag 613381 aaagcggtgt atatgtcacg gtatgtttag cgctgtttat tacattcgcc accatccatg 613441 ccaatattgc cggtttttca agaatggtgt acgcattggc gagagagggg cacatacccg 613501 tattttttgg aaaactcagt gcgacaaaac gtacgcctat tcgcgttttg acagcgatgg 613561 ccgcagtgtt tggcttagtg cttgcagcgc atggtctgtt tcaaatcgat ttgacgactc 613621 tgttgaaagg gccgagcgcg gcttttatcg catcttacat atgtacaatg gcggcagcac 613681 tgaaactgct gggcaggaga gatataggct ggtggatggc gctcggggca tttgtggcgt 613741 gcgcggtgat ttattcattc agcggctggg cactgcttta tccggcagtg ctggcagctg 613801 caggatattt ctatatgaaa acaaagggtg ggcataaaaa aaagcttgat cacgttttgt 613861 gatcaagctt ttccatttat ccgttttgat gctcgttatt tccagaatcg ctgtgttgaa 613921 acatgtaggt cacaggacag aagcgcaaga ttcccgaacc cgctttcatg gcccccataa 613981 agatgtaaaa gagatgcatt ctgcaccaag gttttttcgt aaactttgca ctggcggctg 614041 acataatcgt caatccgcag gcgattctga acacggcatt gatgagactg atgtttggct 614101 tcaaggaaat ccgctccttt tacttaaaaa agttttttaa tcgaaccttc aaaaatttgt 614161 aacgttttta tcgtgcgtga tgaggaagga tgtgatacca tgagtctaat acatgtaaag 614221 gagagtatgt gaatgtccga acgcaccttt aactggaaaa acaaagacat cagggcacag 614281 gttgatgttg tagactcaaa gctgcttcca acgctccttt tacggaatgc tctcgtctta 614341 aatccatatg taaaacaatg gctgaaaaaa aacatttgga tttatcagga ccgcattgtt 614401 tatgtgggtc atgaacttcc gaatagagcc gaagaaattc atacgattga ttgtgaagga 614461 aaatacattg tgccaggtta tattgaaccg cacgcacatc cttttcaaat atataatccc 614521 caaacactgg cggaatatgt gtctcaatac ggaacaacga cattcgtgaa tgataactta 614581 tttttgcttt tgcaaagcgg aaaaaagaaa gcgcttacga ttttgaatga actcaaaaag 614641 cagcctgtcc agtatttttg gtggtcacgc tatgacctcc agaccgaggt tctgaacgag 614701 gaccacgtcc ttccatttga cgtcagaaaa cagtggattg aacatccgga tgtgattcaa 614761 ggcggagaaa tgaccggatg gcctcgcctg gtagatggtg atgatttaat gctccactgt 614821 atgcaagcta caaagaaaca gagaaaacgt attgaagggc attttcccgg cgcttctgat 614881 aaaacgctta caaaaatgaa gctgttcggt gcggattgtg atcatgaagc gatgacaggt 614941 gatgaagtga tgagaaggct ggaactgggc tattatgttt cccttcggaa ctcttccatt 615001 cgccccgatg taagaaaaat cttgcaagag ctgcatgaga agggcttccg ctattatgac 615061 cacttctttt acacgacaga tggcgcaacc ccgaatttct ataaaggcgg catgacaaac 615121 gagctgattc gcattgcgtt agaagaaggc gtacctgcaa tcgacgccta caatatggca 615181 tcatttaata tcgcaaagta ttaccaaatg gatgattatt taggagttgt cggaccgggc 615241 agactggcat cgctaaacat actggaagat ccgttaaatc cgaatccagt gactgttctg 615301 tcaaaaggga ccattctgcg tgaaaacggc tgtgatttga aggcgtttac aaagacggac 615361 tggcacaaag gcggtcttgt cccgcttgag ctttcatatg atatgacgat ggatgacttg 615421 cagttttcta tgccgatggg cgtgaaaatg cggaatgcgg ttattatgga gccatatatg 615481 attgagatcg acaattcgat ggaacagctc tcgtttgacc atgatgaaag ttatttgacg 615541 atgctcgaca gacacgggaa atggcgcgtc aatacgatga taaaagggtt tgcctcaagc 615601 gtgcagggat ttgtaagctc ctttacgacg acgggcgaca ttgtcgcgat tggaaaaaat 615661 aaagcggata tgctgctcgc tttcgcccgc atgaaagaaa tcggaggagg aattgtttta 615721 gcggagaacg gaaacattct gcatgaaatc ccgcttgcgc tgtgcggctg cgcctcttcg 615781 gaagcgtatg aagacgtgct tgagaaggaa caaaagctga gagatctttt gactgaaaga 615841 ggctatgagt tttgcgatcc tatctatacg ctgctctttt tgcaaagtac gcaccttccg 615901 tatatacgca ttacgccaag aggaatattc gacgtcatga aaaaaactgt actctttcca 615961 tcgataatgc gttaaaatat aaaagagcag ggagccgaca tatgaaaaaa tggatgacag 616021 tttgcgcgct gtgtttcgtg ttttttctgc tggtatcctg ccagcagaag gatgctgtcc 616081 cggatactgc aaagaagctg aaagctcctt taacggggct aaagactgaa cagaaagtga 616141 ctgaacgccg ccctgttgct gttgtggtga acaatcaccc gaaggcgagg ccgcagtcgg 616201 gtctgtctaa agccgacatt gtcatagaag cgctagccga agggcaaatc acaagatttc 616261 tggccatttt ccaaagccag atgcctgaaa ctgtcggacc tgtgcggagc gcgcgggaat 616321 atttcgtcac tctcagcaat ggctttgaca gcatatttgt ccatcacggc tggagtcccg 616381 gcgccaaaaa gcagctggaa tccggagctg ccgattatat gaacggattg gattttgacg 616441 gaagcttatt ttggagagct gatttcagca aaccgcccca caattcctat acgtcttatg 616501 attacataaa aaaggcggca gaacaaaagg gttataagct gaagcaggaa acaaatccgc 616561 tgctgtttca aacatcagat gcaaaacctg caaatgaatc ttacaatgtt cgggtagatt 616621 atggaacaaa taacgttaca aatcttgtcg aatacaacta tgataaaaaa gctgaatttt 616681 atacaagaag ctctgatggt gtcataacga cagaccggga aaccggaaag ccggttgcaa 616741 tgcaaaatat tttcattgtt gaagccagcc atcatattat tgatcaagat ggaaggcggg 616801 acatcgactt ggaatcagga ggaaaaggtc tgttgtttca gcacggaaac gtcattgaaa 616861 cagactggaa acaagtgaat ggcagaattg tgccggtaaa agacggcaag tggcttccgt 616921 ttgtgccagg aaagacttgg atcaatatcg tacctgatct tgatgcggct tccattagta 616981 aaggagaagg tgtgtaacga tgcaaatcga taaattacgc ggcaaagagc tggaccagtt 617041 atttaactcg atcttatcgc tgaaagacct ggaggaatgt taccgattct tcgatgatct 617101 atgcacaatt aacgaaattc aatcgctggc tcagcgcctt gaagtggcgc gcatgcttcg 617161 cgaaggaaac acgtatcata agattgaaac agaaacaggc gcttccacgg ctacgatttc 617221 ccgtgtgaaa cgctgcttaa attacggaaa tgacgcttat gaaatggcgc ttgaccgtgt 617281 gaaggagacg gaaacagagt cttcttccaa ataaaaaacc gccctgccgt ctggcaaggg 617341 cggtttcttt atgaaacaaa ttgatggatc aggttgtcga tattgatgat actgccatcc 617401 tctttccgat agacaacatg ctccttggaa aaatgaatcg gcgaattaat ccctgctgcg 617461 gctgcaaggt taaatagtcc ctcgcgcaat gaaataacgt agttgcagac acgatgctgt 617521 ttttcctcaa cgctcagtgc tttttgcaat ttcggatctg tcgtcgccac acctgccgga 617581 caggtgttgg tgtggcagac gagagcgcgg atgcagccaa cggaaaacat catgccgcgt 617641 gcgatgttaa caaagtcagc gccgagggct aaggcgaccg cgattttatc aggagtcagg 617701 agctttccgg aagcaaagat tttcagctgg ctgcgcaagc cgtactgttt aagaagcgtg 617761 tccacaatag gcagcgctgt cataatcgga aggccgactg tatccgcgag ctcgtaaaag 617821 gaagctccgg taccgccttc acttccgtcg atcgtgataa aatccggatg ctttccgctt 617881 ttctgcatat gagagaaaag ctcatgcaat tcttcaggat gccctgcgac cagtttgatg 617941 ccgactggct tttgtccgac atctctaagt ttttcaataa agtcgagcat ttcaggaggg 618001 tttgagaatt cataaaagcg gttcgggctg tcaatcgact ttccaggttc gacattccga 618061 atgtctgcca cttcctctga tactttggcg ccgtccacat ggccgccgcg ggttttcgct 618121 ccttgtgcca gctttagctc aaacgcttta atctggtcaa tcctgctttt tcttttaaat 618181 tcctcccacg aaaattcccc gtttcttttg cgcacgccga ataggcccgg tccgatttgg 618241 caaatgatat cggcgccgcc ctttaagtga tattcagaca atcccccttc acctgtattc 618301 atccaggtgc cgcctgccag atggagccct tttgagagcg ccgtaacagc ccgttctcca 618361 agagaaccgt agctcatggc agactggccg actaagccct tcacataaaa tggcttctcg 618421 catgtatgct cgccaatcac ctgtacatca tcaggatgga gaaaatacgg gtctgccttg 618481 atatgttcgg catgctcctt gcgtttgaac agattgtcag catccatttt atagatttgg 618541 gtttcaattt ttggcgtttg atttacatgc atttcttccc tttgttttgg aaacatagcg 618601 ttacggatat aatagccagg tttatcaaaa tctcttacag atccaaagcc catcattctg 618661 cttttgtatt tgccggagat gacggtttgc tcatattcct ttcgtgaaaa tggctgctct 618721 tcattgtcat tgctgtataa atactgtctg agctccggcc cgattttttc aaggatatac 618781 cgaaaccttc cgatgacggg atagttgcga agaattgagt gctcctgctg tttttcatcc 618841 tttatgtaga tccaggcaaa caagacgatc gggatagcga tgatcccaat gataaatgcg 618901 atgagtgcta ttatgatggt ttccatctct cagcctccct ttttatgtaa ccatttccac 618961 agtagaacac tttccaaaca atagcagaag gaatctggtg aaaaatgtgt gctcctgccg 619021 atacaggact caccatgcag gtactgccat atgctctctt tttttatgaa aaaagaatca 619081 aaacaccttt ttcagtgaat aacgagatta acggcttttt ccgtttttcc gcgctatgtg 619141 aatttgttat aatgtttaaa tggtaacaaa cgaatggagg aacgtatgac gtgtacgatg 619201 taacggagtg gaagcatgtc tttaaactcg atccaaataa agatttgcct gacgaacagc 619261 tggagattct ttgcgaatca ggaacggatg cggtcattat cggaggaagc gatggtgtga 619321 cagaggataa tgtcctgcgg atgatgtcta aggtaagacg gtttttggtg ccgtgtgtcc 619381 tagaggtatc agcgattgaa gcgattgttc ccggctttga cttatatttt attccgagtg 619441 tattaaacag caaaaacgcg gattggattg tcggaatgca ccagaaagcc atgaaggaat 619501 acggagaact gatgtctatg gaagaaatcg tggcggaggg ctactgcatc gcaaatccag 619561 attgcaaagc cgcggcactg actgaagcgg acgccgatct gaatatggat gatattgtcg 619621 cctatgcgcg tgtgtcggag ctgctgcaac tgccgatttt ttatttagaa tacagcggcg 619681 tgcttggaga catagaagct gtcaagaaaa cgaaggctgt attggaaacg tccaccttgt 619741 tttacggcgg cggcatcaag gatgcggaaa cggccaagca gtacgcagag catgcggacg 619801 tgatcgttgt aggcaatgcg gtgtatgaag attttgacag ggctttgaaa acagtagcgg 619861 ctgtgaaagg cgagtagtaa attgtacgga tttggtttat gatagaacgt atgttttgta 619921 taggcgggtg aacaaatttt gaattatatt agcaatcaat tactaagcgg tttaaacccc 619981 gttcagcagg aagcagtcaa aacaacggac gggcctcttt tgctgatggc gggagcgggt 620041 agcggaaaga cgcgtgtcct gacccataga attgcttatt taatggcaga aaagcatgtg 620101 gcgccgtgga acattctggc gatcacattt acaaataaag cggcacgcga aatgaaagaa 620161 cgtgtggaaa gcatcctcgg acccggcgcg gacgatatct ggatctccac attccacagc 620221 atgtgcgtgc ggatcttgcg cagagatatc gaccggattg ggatcaaccg aaatttctcc 620281 atccttgata cggctgacca gctttcagtg atcaagggga ttttgaagga gcgcaatctt 620341 gatccgaaga agtttgaccc gagaagcatc ctcggcacga tcagcagtgc aaaaaacgaa 620401 ttgaccgaac cggaggaatt ctctaaagtt gctggcggct actacgatca ggtggtcagc 620461 gatgtatatg ctgattatca gaagaagcta ttgaaaaacc agtcgctcga tttcgacgat 620521 ttaattatga cgacgattaa actgtttgac agagtgcctg aagtgcttga attttatcag 620581 cgcaaattcc agtacatcca cgttgatgag tatcaggata cgaacagggc acaatacatg 620641 ctcgttaagc agcttgccga gcgtttccag aacctttgcg ttgtggggga ttctgatcag 620701 tcaatctaca gatggcgcgg cgcggatatc accaacattc tttcatttga aaaagattat 620761 ccgaatgcaa gcgtgatttt gctagaacaa aactatcgtt caacgaaacg gattttgcgc 620821 gcggctaacg aggtcattaa aaacaactct aaccgcaaac cgaaaaattt gtggacggaa 620881 aatgatgaag gcatcaagat ttcctattat cgcggtgata atgagttcgg tgaaggacag 620941 tttgtggccg gcaaaattca tcagcttcac agcacaggca agcggaagct gtcggatatc 621001 gccatattat accggacaaa cgcgcagtcc cgtgtgattg aggaaacgct tctcaaagcg 621061 ggcttgaact ataacattgt cggcggcaca aagttctatg acagaaaaga aattaaagac 621121 attcttgcgt acctgcgcct cgtatccaat ccggatgacg atatcagttt cacgcgcatt 621181 gtcaatgtgc cgaagcgcgg agtcggcgcg acatcacttg aaaaaatcgc ttcgtatgcg 621241 gccataaacg gcttgtcctt tttccaagcg attcagcagg ttgattttat cggcgtcagt 621301 gccaaagcgg caaacgcgct tgacagcttt agacagatga ttgaaaacct gaccaatatg 621361 caggattact tatccattac agagctgaca gaagaaattc ttgataagac ggaatacaga 621421 gaaatgctga aggctgagaa atcgatcgaa gcccaaagcc gtttagaaaa tatcgacgag 621481 ttcctgtctg ttacgaaaaa ctttgaacag aaaagtgaag acaagacact cgttgcgttc 621541 ctgacagact tggcattgat cgcagatatt gatcagctcg atcagaagga ggaagagtca 621601 ggcggcaagg atgcgatcac cctgatgaca ctgcacgccg cgaaaggact ggagtttccg 621661 gttgttttct tgatggggct tgaagaaggc gtcttcccgc atagccgttc actcatggag 621721 gaagcggaaa tggaagaaga acgccgcctt gcgtacgttg ggattacaag ggcggaacag 621781 gagctttatc tgaccaatgc taaaatgcgc accttgtttg gccggacaaa tatgaacccg 621841 gaatctcgct tcattgctga aataccggat gatttattgg aaaacctaaa tgagaaaaaa 621901 gaaacaagag cgacgtctgc gagaaaaatg cagccgagac gcggccctgt ttcacgcccg 621961 gtatcctacg ccagcaaaac aggcggcgac accttgaact gggcagtcgg agataaggcg 622021 ggccataaaa aatggggaac aggaactgtc gtcagcgtga aaggcgaagg agaagggaca 622081 gagcttgata ttgccttccc gagccctgtc ggcgtgaaac gcctgttagc agcatttgct 622141 cctattgaaa agcagtaatt gaagaggaaa ggaagaagca gatggacaaa gaaacagcga 622201 agcagcgggc agaagaactg cgccgcacca tcaacaagta tagctatgaa tattacacct 622261 tagatgaacc gagcgtccca gatgccgaat acgacagatt gatgcaggag ctgatcgcga 622321 tcgaggagga gcacccagac ctcagaacgc ctgactctcc tacgcagcgc gtcggcggag 622381 ccgtgcttga agcgtttcag aaagtcaccc acggcacacc gatgctcagt ctgggcaacg 622441 cctttaatgc tgatgatctt cgtgatttcg accgccgtgt gcgccagtcc gtcggcgacg 622501 atgtggcgta taatgtggag ctgaaaatag acggtcttgc tgtttctctc cgttatgaag 622561 acggctattt tgtcagaggg gccacaagag gtgacgggac gacgggagag gatatcacgg 622621 agaatctgaa gacgatccgc aatatccccc ttaaaatgaa ccgtgagctg tcgatcgaag 622681 tgcgcggcga ggcgtatatg ccgaagcgtt cgtttgaagc actcaatgag gaacggatta 622741 aaaatgagga agaaccgttc gccaatccgc gaaatgccgc ggcgggatct ctcagacagc 622801 tcgatccgaa aattgcagcg aaacgaaacc tcgatatctt cgtctacagt atagcggagc 622861 ttgacgagat gggtgtagag acgcaaagcc aagggcttga ttttctcgac gaactcggat 622921 ttaaaacgaa tcaggaacga aaaaaatgcg gcagcataga agaagtcatt acgctgatcg 622981 atgagcttca ggcgaagcgc gcggacctgc cgtacgaaat agacggcatt gtcattaaag 623041 tcgattctct cgatcaacag gaggagctcg gttttacggc gaaaagcccg cgctgggcca 623101 tcgcgtataa gtttcctgct gaagaggtcg tgacgaagct tctcgatatc gaattaaatg 623161 tcggcagaac gggtgtgatt acgccgactg cgattcttga gccggtaaaa gttgccggca 623221 caacggtctc aagagcatcc cttcataacg aagatttaat taaagagaag gacattcgga 623281 ttttggataa ggttgtcgtc aaaaaagcgg gcgatatcat cccggaagtt gtgaatgtcc 623341 tcgttgacca gcgcacagga gaagaaaagg aattcagcat gccgacggaa tgtcctgaat 623401 gcggcagtga actcgtccgg atcgaaggag aagtggcgct tcgctgcatt aaccctgaat 623461 gtccggcgca aatccgggaa gggcttatcc atttcgtttc ccggaatgcc atgaacattg 623521 atgggctcgg cgaacgagtg atcacacagc tgtttgagga aaaccttgtc cgcaatgtgg 623581 cagatttata taagctgacg aaggaacgag tcatccagct cgagcgcatg ggcgaaaagt 623641 ccactgaaaa cctgatcagc tccatccaaa aatcaaaaga aaattcgtta gagcgcctgc 623701 tgtttgggct tggcatccgt tttatcggat caaaggccgc aaagacgctt gccatgcatt 623761 ttgaaagctt ggagaacctg aaaaaagcct ctaaagagga acttctcgcg gtagatgaaa 623821 tcggtgaaaa aatggctgat gctgtgatca cctattttca taaagaagaa atgcttgaac 623881 tcttgaatga acttcaggag ctgggcgtaa acacgctcta caaaggcccg aaaaaagtaa 623941 aagcagagga cagcgactct tactttgctg gtaaaacaat tgttctgaca ggaaagctgg 624001 aagagctgtc aagaaacgaa gccaaagcgc aaatcgaagc gctgggcgga aagctgactg 624061 gaagcgtcag caaaaacaca gacttagtca tcgccggaga agcggcggga agcaagctga 624121 caaaagcaca agagctgaac attgaagtgt ggaatgaaga acagttaatg ggagagctaa 624181 agaaataaga ggagtgtttt ctattgaaaa agacgttggc attggcggca acggcggcag 624241 tattaatgct gtctgcctgc tcgtcaggtt tcggggggga gaaggaggaa gagattacgc 624301 aaaagacggc gaaatcgtca gaaaaagcga ttgtcccgaa atataatatc tctgactcct 624361 attacaaaat ggtgctgccg tttaaggcag gcaaagcgcg cggcttaaca acggaacagc 624421 tgaatacaag gctggacatt gacgaatttg aaacagggct gatgcgcctt gcccaagatt 624481 ctttctcaac tgacgattat ctgttccaag aaggacaata tttagatgag gatacagtat 624541 taagctggct ggcacggaaa aaaacgggct ctgatttgaa aaaagccgaa aaagaagata 624601 agaacttcaa aaatgaaggc ttgaacccgg cgctcccgag ttctggttca acagaagaaa 624661 agaacgaaag cagcccaatt tatttagcat ccatgcttga gcacgattat ttagtcagaa 624721 aagacaagaa ttctatccag cttggcggcg tcatgatcgg actggcgtta aactcagtgt 624781 attactatcg tgaaaaaact ggcgacccgc aaaaagaagt ggagattaaa gacagcacgc 624841 ttcgccagca gggagaaaaa attgcacagg aggttattaa ccgcctccgc aaaaaagata 624901 acttgaagaa tgtgccgatt accgtggcgc tctacaagca ggcgtcaaaa acatcgattg 624961 tgccggggaa cttcatcgcc aaaacagagg tcaaagcagg ctctactgat atctcaaatt 625021 gggatgacat caatgaaaaa tatgtattct atccggcgga tacaaccaca gcagaaaagt 625081 acccggatga caccgaggtc tttaagcggt tcaaaaactc aattgaagaa tatttcccga 625141 actatacagg cgttgtcggt acagcgctgt atgaaaatga tgaaatgaag aaaatgaaga 625201 ttgacatacc aatgcaattc tacggaaaaa gtgaagttgt cgcgtttacc cagttcttaa 625261 cgggtgaagt gatggactac tactctaaga gctcagttga tgtcgaagtc aatatcacgt 625321 cctcagacgg acaggaagcg gtcattatcc gcaatgccgg agataaagag ccgactgttc 625381 acatttatga ctgatagaaa acccttgtgc catattggca caagggtttt tatgttacaa 625441 ttaacaggaa aagggaaaat attttcactt ctgccgaaac acaaatcaag gggaggtatg 625501 ttgatgctgg aaatcgtgtg aaaacaatca ttatcaaatc tatagcaatg aaaggatgtt 625561 agacgtgcat aaagatatca aaaaaatatt tcatgaagag caggttttgg cagaagctgc 625621 agcgagatac ggtttctcaa aagatcaggt gcgttttctg gctgatgcgg aaaactatgt 625681 atatgaatgt atgaaagaca atcaacctta tattttaaag attacccata cgattcggag 625741 atcttctgat tatatgatgg gagagatgga atggctccgt caccttgcaa tagggggaat 625801 ttcagtagcc aaaccgctcc cgtcgctgaa cggaaaagac gtagaagcag tgccggacgg 625861 aaacggcggg tcatttttat tgagagtgta tgagaaagcg ccggggcaaa aagtggatga 625921 atcggactgg aatgaaacgc tattttatga gcttggcaga tacacaggca gcatgcacag 625981 cctgacaaaa agctacaaat tgagcaatcc cgctttcaaa agacaggaat gggatgaaga 626041 ggagcaatta aagctgagaa aatatgtgcc tgaagatcag ataaaggtgt ttcagcaagc 626101 cgattctttg atgaatgaac tgcggaggct cccgaaaagc caggacaact acggcttggt 626161 gcatgcggat ctgcaccatg gcaattttaa ctgggatcat ggcaaaatca cggcatttga 626221 ttttgatgat atcggctaca actggtttgt taacgatatt agcattcttc tctacaatgt 626281 cctgtggtat cctgttgtgc catatgatga taaagctgcg tttacagaag aatttatgac 626341 gcattttatg aaagggtact gggaggaaaa tgagcttgac cctgcatggc tgatgataat 626401 acctgatttc ctccgccttc gccatatgct gatttacgga ttgctgcatc agatgtttga 626461 ccttaacaca ataggagaag aggaaaaaga aatgctggcc ggtttcagaa gagatataga 626521 gaatggcacg ccgattacag catttgattt ttcagcactg gtgtagatag aaaaagccaa 626581 tgggattcca gtcccattgg cttttataat gtatcacact tcacgccgac tacgccttca 626641 atggctttaa tgtcatagta gacatcggtc gtgtatctgt ttttatggac gcggaccttc 626701 acttccataa ttggaaaatc cttttcgcct aggtcgtcga tccgaacgga gtgtgctttg 626761 atatctcttc ttttcatttc ttttaaaatc tctgtcattt tgtctttatc agaaagtgac 626821 attctgatgc ggatgtcttt ttcctgcagg cggtcggggc cgatttttct gaccacccat 626881 gggagaaatt ccacactgat caggatgaac agaagactgg caaacgcttc tttataaaaa 626941 ccggctcccg tagcaagccc gagccccgct gccccccaga tcatggccga tgtcgtcagg 627001 ccggaaatga catcattgct ttttcgcagg atgacaccgg cgccgataaa cccgacgccg 627061 gagatgattt gtgccggcag acgaagcgga tccatcatga tgcggtagta tttagggaaa 627121 tgatatgccg cattaatact gacgatcgtc agcatgcatg agctgactgc gatgacaata 627181 caggttttta atccgagcgg cttatttttt aattcgcgtt caagcccgat gaccatgcca 627241 atcaatgtgg caatgcccaa tttcaataaa atatcaggat caatatacca gctcaacagc 627301 aaacttcccc cttctctatg gtgtttttaa ataaatatga ttttctcaca gtatttatag 627361 caaaacaaga gcacaaaagc caccaagctg cgcttgatgg cttattgctt actttttgcg 627421 ttttaacagc ttttccatga caccgaataa tcggtaagag gcttttgcag gacgttttgt 627481 gatcatgctg acaatgatgc cggcaatcat actgagaata aacccaggga tgatttcgta 627541 cacaccggtt gattttgcca ggccggttgt aatccagatc aacacggtcg cagccccgac 627601 aatcatggca gcaagcgcgc cccattcgtt cattcgtttc caatacagac tgagcagaat 627661 cgcaggcccg aaagctgaac cgaagccggc ccaagcgtat ccgaccaaat caagaatggt 627721 gctgttcggg ttcaatgaca agagtaccgc gataacggca atgactaaga cggacaatcg 627781 cccgatcatg accaattctt tatcagaagc ttttcgtctg aaaaatgacc ggtataaatc 627841 ctctgttaca gcacttgctg tgaccaagag ctgtgaggaa atcgaactca tgatggcagc 627901 caaaatagct gacaataaga accctgtaat taatgggtgg aacaagattt tagagaagat 627961 aatgaaaatc atctccggat cttttacagc aactccgaat ttatgggcgt atgcaacacc 628021 gattaaaccc gtcagcacgg aacctagaac tgtaatgatc atccagctca tgccgattcg 628081 gcgtgcaggt tttaaatctt taatgtcttt aatggccata aatcggacga tgatatgagg 628141 ctggccgtag tagcccaacc cccaggctaa ataggaaata atgctaatga cgctcgcgcc 628201 tttaaaaata tccaataaat gtggattaac agcgtcgatt tcatggaaag tcggagcaac 628261 gccgcccaca tgggtaaaag caacgatcgg cacaagcact agtgctgcaa acatgatcgc 628321 accctgcacg aagtcagtca gactgacagc aaggaaaccg ccaaacagtg tgtataacac 628381 gacaactgcg gtggtcagaa acaggcctaa tttgtaatcc gcaccaaaag cagattcaaa 628441 cagccgtccg ccagatacca taccggaaga ggtatacaat gtgaaaaaga tcatgatgat 628501 caatgcagat acgattttca gcagtgatga agaatgctgg aatcgtttat caaagaaatc 628561 aggaattgta atcgcatcat ctgccgcttc tgtataagca cgcagccttg gagccagcag 628621 caagtaattt gagtacgccc cgattgtaag acctaaagca agccataagg tggacagccc 628681 tgtcgcaaac atcgcgccgg gaacacccat cagcatccat ccgctcatat cggccgcgcc 628741 ggcagacaaa gcagtaacga atggtccgag gcctcttcct ccaagcatgt aatcattgat 628801 gtcagtggtt ttcttgaatg cataccagcc gattaacagc atggcaataa agtaaattcc 628861 taaagatata ataatttcaa tactcacgtt ttaccctctc ttcatttcta ataatgttgc 628921 atcacctctc aaattgatgg tgccagttaa gcagcctggc gtaagtgcaa aacaaaagaa 628981 attcttttgc gggtgcactt ggtaacttaa cctaacaaag tattcccggc cattcaagcg 629041 atgaaacatt gatcataagc tggaaatacc gttgcaaacc tagaagggaa taaagaataa 629101 aacgctttca aaaaataatt aaagtaaaaa tattcagaaa aatatttcgt ttctccttct 629161 cctcatttta gtataaaata tatagggtat tgtttcgaaa acacaggcct gtctcaaggc 629221 gttttgttgc tttaaagggc ttgtttttga tatgatcagt attatatgac ttaacggaga 629281 aatatgtgga ggtggatcat atgtcacgaa tttcaataga agaagtaaag cacgttgcgc 629341 accttgcaag acttgcgatt actgaagaag aagcaaaaat gttcactgaa cagctcgaca 629401 gtatcatttc atttgccgag gagcttaatg aggttaacac agacaatgtg gagcctacaa 629461 ctcacgtgct gaaaatgaaa aatgtcatga gagaagatga agcgggtaaa ggtcttccgg 629521 ttgaggatgt catgaaaaat gcgcctgacc ataaagacgg ctatattcgt gtgccatcaa 629581 ttctggacta aaggagggac acaagaatgt cattatttga tcataaaatc acagaattaa 629641 aacagctcat acataaaaaa gagattaaga tttctgatct ggttgatgaa tcttataaac 629701 gcatccaagc ggttgatgat aaggtacaag cctttttggc attagatgaa gaaagagcgc 629761 gcgcatacgc gaaggagctt gatgaggcgg ttgacggccg ttctgagcac ggtcttcttt 629821 tcggtatgcc gatcggcgta aaagataata tcgtaacaaa agggctgcgc acaacatgct 629881 ccagcaaaat tctcgaaaac tttgatccga tttacgatgc tactgtcgtt cagcgccttc 629941 aagacgctga agcggtcaca atcggaaaac tgaacatgga cgaattcgcc atggggtcat 630001 ctacagaaaa ctcagcttac aagctgacga aaaacccttg gaacctggat acagttcccg 630061 gcggttcaag cggcggatct gcagctgcgg ttgctgcggg agaagttccg ttttctcttg 630121 gatctgacac aggcggctcc atccgtcagc cggcatcttt ctgcggcgtt gtcggattaa 630181 aacctacata cggacgtgta tctcgttacg gcctggtcgc atttgcgtct tcattggacc 630241 aaatcggacc gattacacgt acggttgagg ataacgcgtt tttacttcaa gcgatttccg 630301 gcgtagacaa aatggactct acgagtgcaa atgtggacgt gcctgatttt ctttcttcat 630361 taactggcga catcaaagga ctgaaaatcg ccgttccgaa agaatacctt ggtgaaggtg 630421 tcggcaaaga agcgagagaa tctgtcttgg cagcgctgaa agtccttgaa ggtctcggcg 630481 ctacatggga agaagtgtct cttccgcaca gtaaatacgc gcttgcgaca tattacctgc 630541 tgtcatcttc tgaagcgtca gcgaaccttg cacgctttga cggcatccgc tacggctacc 630601 gcacagacaa cgcggataac ctgatcgacc tttacaagca aacgcgcgct gaaggtttcg 630661 gaaatgaagt caaacgccgc atcatgctcg gaacgtttgc tttaagctca ggctactacg 630721 atgcgtacta caaaaaagcg caaaaagtgc gtacgttgat taagaaggat ttcgaggacg 630781 tatttgaaaa atatgatgtt attgttggac cgactacacc gacacctgcg tttaaaatcg 630841 gtgaaaacac gaaggatccg ctcacaatgt acgcaaacga tatcttaacg attccggtca 630901 accttgccgg cgtaccggga atcagtgtgc catgcggatt agcagacgga cttccgctcg 630961 gcctgcaaat catcggaaaa cactttgatg aaagcactgt ataccgcgtt gctcatgcat 631021 ttgaacaagc aacagaccat cataaagcaa aacctgaact gtaaggggtg aaaagaattg 631081 aactttgaaa cggtaatcgg acttgaagtc cacgttgagt taaaaacaaa atcaaaaatt 631141 ttctcaagct ctccaacgcc attcggcgcg gaggcgaata cgcagacaag cgttattgac 631201 ctcggatatc cgggcgtcct gcctgttctg aacaaagaag ccgttgaatt cgcaatgaaa 631261 gccgctatgg cgctcaactg tgagatcgca acggatacga agtttgaccg caaaaactat 631321 ttctatcctg acaacccgaa agcgtatcag atttctcaat ttgataagcc aatcggcgaa 631381 aacggctgga tcgaaattga agtcggcggc aaaacaaaac gcatcggcat cacgcgcctt 631441 catcttgaag aggatgccgg aaaactgacg catacgggcg acggctattc tcttgttgac 631501 ttcaaccgtc aaggaacgcc gcttgttgag atcgtatcag agccggacat ccgcacgccg 631561 gaagaagcgt acgcatatct tgaaaagctg aaatccatca tccaatatac aggcgtttct 631621 gactgtaaaa tggaagaagg ctcacttcgc tgtgacgcca atatctctct tcgtccgatc 631681 ggccaagagg aattcggcac aaaaacagaa ttgaaaaact tgaactcctt tgcgtttgtt 631741 caaaaaggcc ttgagcatga agaaaaacgc caggagcagg ttcttctttc cggcggcgtc 631801 atccagcaag aaactcgccg ttatgatgaa gcaacgaaga aaaccattct tatgcgtgtc 631861 aaagagggat ctgacgacta ccgttacttc ccagagccag atctagtcga gctctacatt 631921 gatgatgaat ggaaggaacg cgtaaaagca agcattcctg agcttccgga tgagcgccgc 631981 aagcgttata tcgaagagct tggcttgcct gcatatgacg caatggttct gacgctgaca 632041 aaagaaatgg ctgatttctt cgaagaaacc gttcaaaaag gcgctgaagc taaacaagcg 632101 tctaactggc tgatgggtga agtgtcagct tacctaaacg cagaacaaaa agagcttgcc 632161 gatgttgccc tgacacctga aggccttgcc ggcatgatca aattgattga aaaaggaacc 632221 atttcttcta agatcgcgaa gaaagtgttt aaagaattga ttgaaaaagg cggcgacgct 632281 gagaagattg tgaaagagaa aggccttgtt cagatttctg acgaaggcgt gcttctgaag 632341 cttgtcactg aggcgcttga caacaatcct caatcaatcg aagactttaa aaacggaaaa 632401 gaccgcgcga tcggcttcct agtcggacag attatgaaag cgtccaaagg acaagccaac 632461 ccgccgatgg tcaacaaaat tctgcttgaa gaaattaaaa aacgctaata aaaaagcagc 632521 ccttagaggc tgcttttttt atggtcaaat tgagataaag acaagatgag ggcccgaagc 632581 ctttcaactt ctttgtcgtt ggttccggcc aaattggaca gcatgccttt aataatcggc 632641 ttgcgcggtt tatcctgagt caattcttcc tcgataacat caagtgacac ggtgatatcc 632701 tcgggcagcg tgctgttttc tttcactttc tgaatgtcct caagcagctg gtcttttccc 632761 gcaggcatcg ggttaaaaat gtcttttgat acaatcggat tgagtgcaga acggctcagc 632821 ccctgtacaa gatcatccag tctctcaata ataaaggctg agatttcttc tgcatcgata 632881 ttaagctcac cgttaaatac catcacgttc atataggaat gcacaatgcc tcttgccatg 632941 atggacagat ctgcgacata ccgctcgatt ccttcgccat aggataccag caaggcgttc 633001 cggtacagct tatccgtctc catggttact ttgtaaaagt attgcttgat ttcttgattt 633061 tccggaatga tattttcggt aagcaaaaga acgataaaat ctttatgatc gcgaaaatcc 633121 tcaaattgag cgccaatttg cttttttaac acttccttag gcggctttcc ggcgagatct 633181 tcttctatat ttttcatttt gttcatagac ataccgatat aatattcaca ggcagataac 633241 agcagcgctt ctttcgattt gaagtgcaaa taaaaagcgc ccttcgaaat gccgcattca 633301 ctggcgattt cttggatcgt cgtagctgcg aatccttttt tcgcaaataa acgaatgctg 633361 gtttttatga ttctctcttt tttttcattc atgacgtgct tccccttaat ccttgaaaaa 633421 tttagtaaaa ttttctggta tatgagttga cgttgttgcg ttataacgtt tagtattata 633481 tagaatgacc agtcagtcaa taaaaaatgt aatggaggat atgatgaacc acgttattaa 633541 tttcgttctg aaaaacaaat tcgccgtatg gctgatgacg attattgtaa cggcagccgg 633601 cttgtatgcg ggtatgaata tgaagcaaga gtctattcct gacgtgaaca tgccttactt 633661 gacgatcagc acgacatatc cgggtgcaac accaagccaa gtggctgatg aagtgaccaa 633721 accggttgaa caagccgtac agaacttgga cggtgtcagc gttgtgacgt cgacgtccta 633781 tgaaaacgca tcgtcggtca tgattgaata tgattatgag aaagatatgg acaaagcgaa 633841 aacagaagca gctgaagcgt tagaaaacgt caacctgcct gatgacgcga aggatccgga 633901 gatttcacgc tacagcttga actcattccc gattctgacg ctgagcgtgt ccagtgataa 633961 agataatctg caagagctga cgaaacaagt ggaggacagc ctcgtttcta agcttgaagg 634021 catagaaggc gttgcgtccg tccaagtatc aggccagcag gtggaagagg ttgaattctc 634081 tttcaaagaa gacaaactga aggaatacgg ccttgatgaa gatacagtca agcaagtgat 634141 tcaaggttca gatgtgacaa ctccgcttgg attgtacaca ttcggaaatg aagaaaaatc 634201 tgtcgtcgtc agcggcgata ttgaaacaat taaagatttg aagaatatga gaatcccgac 634261 ggcatctgct tcaagtgcag gcagcagcgc agcatctcaa gcaggtgcgc agagtgctca 634321 agcagcccaa agcgcgcaag cggcagcaca ggtgcagcaa agcgcaagca cagcagtgcc 634381 gacggtcaag ctttctgaca ttgctacaat taaagatgtg aaaaaagctg aatccgtttc 634441 acgcacaaat ggcaaagaca gcatcggcat caacatcgtc aaagcaaacg atgcgaatac 634501 ggtagaggtt gccgacgatg tcaaagctga gctgaaaaag ttcaaagaag accataaagg 634561 cttcaattac agcgcaactc tcgacatggc ggagccgatc acacagtcag ttgacacgat 634621 gttaagcaaa gccatcttcg gtgctatttt tgcgattgtg attattctct tattcttaag 634681 agatatcaaa tcaacattaa tttctgttgt ttcaattcca ttatcattgc tgatcgcact 634741 ccttgtgctg cagcagcttg atatcacatt gaatattatg acgctcggcg caatgaccgt 634801 tgccatcgga cgtgtagtcg atgactccat cgttgtgatc gagaacattt accgccgcat 634861 gagactcaaa gatgagccgc tccgcggaaa agccttggtt cgtgaagcga cgaaggaaat 634921 gtttaaaccg atcatgtcat caacgattgt gacaatcgcg gtattcctgc cgctcgcact 634981 tgtaggcgga caaatcggtg aattgtttat tccatttgcc ttaacgattg tttttgcgct 635041 tgccgcatcc ctagtgattt caatcacgct tgtgccgatg ctcgcacaca gcctgttcaa 635101 aaaatcatta accggtgcgc cgattaaagc gaaagaacac aaacctggca gacttgcaaa 635161 catctataaa aaagtattga actgggcgct gagccacaaa tggatcacgt ctatcatcgc 635221 ggttctgatg ctccttggaa gcttgttcct cgtaccgtta atcggtgcca gctacctgcc 635281 gtccgaggaa gaaaaaacga tgcagctcac atacagccca gaaccgggtg aaacgaaaaa 635341 agaagccgaa aatgaagctg aaaaagcgga aaaaatcctg cttgaccgca agcatgtcga 635401 tacggttcag tattcattag gctctggcag cccgcttgcc ggaggagatt ctaacggtgc 635461 gttattctat atcaaatatg aaagcgacac acctgacttt gataaagaaa aagataacgt 635521 tctgaaggaa atccaaaagc aatctgaccg cggagaatgg aagtcacagg acttcagctc 635581 ttcaggcaat aataacgaat taacatacta tgtgtatggc gattctgaaa acgatattaa 635641 agacacggtc aaagacattg aaaaaatcat gaaagatgaa aaggatctga aaaacgtaaa 635701 ttcaggcctt tccagcacat atgatgagta cacatttgtc gctgaccaag aaaaactaag 635761 caagctcggt ttaaccgcgt ctcaaatttc tcaggcctta atgtcacaaa catcgcaaga 635821 accgctcacc actgtgaaaa aagacggcaa agagcttgat gtgaacatta agacagaaaa 635881 agacgagtat aagagtgtga aagatttaga gaataaaaag atcacttccg cgactggcca 635941 ggaagtcaaa atcggcgatg tggcaaaagt gaaagaagga tcaacatcag ataccgtgtc 636001 aaaacgtgac ggaaaagtct atgcagatgt cacaggtgag gttacctctg acaacgtcac 636061 agccgtatca gctgctatcc agaagaaaat cgataagctt gaccaccctg ataacgtatc 636121 gattgacaca ggcggcgtat cagcggatat cgctgattcc ttcacgaagc tcggtttagc 636181 gatgctggca gcaatagcga tcgtttacct tgtgctcgtg attaccttcg gcggagcact 636241 agcgccattt gcgattctgt tctcattgcc gttcacagtc atcggtgccc tggtcggact 636301 ttacgtatca ggtgaaacga tcagtctgaa cgccatgatc ggtatgctca tgctgatcgg 636361 tatcgttgtc acgaatgcca ttgtcttaat tgaccgcgtg attcataagg aagcggaagg 636421 cctgtctacg agagaagcgc tcctggaagc cggctctaca cgactccgtc cgatcctgat 636481 gacagccatt gcgacaatcg gcgccttgat tccattagcc ctcggcttcg aaggcggaag 636541 ccaggtcatt tcaaaaggac tcggcgtaac ggttatcggc ggtttaatca gttcaacgct 636601 tctgacgctc ctgatcgtgc caatcgtata tgaagtattg gcgaagttcc gcaagaaaaa 636661 accgggaacg gaagaagagt aaaaaacaaa aagcctcagc tctgctgagg ctttcagctt 636721 gttgaaaaac cctcgcattc gttgtcaggt ctgcgcgtcg gtgctcacga attctacatt 636781 cgctccgctc caatgctccc ccttcctaga ctacaagggt tttcaatcaa gctgaaagaa 636841 tgttaaggat gacaaaagct caaaacaaga atcagttttg agcttttgtg cgttttcacc 636901 tgtaagatta tgtacatttt gttgcgattt ttttaactca tagtataatt aaaggttgtt 636961 agtgtaaaaa tggatcggat actcttaagt aggatgatga gataatgaaa cgtgcacgca 637021 taatatacaa tccgacttca ggacgggaga tctttaaaaa gcatcttgcc caggtcctgc 637081 aaaaatttga acaagccggc tatgaaacct ccacccatgc gacgacatgc gcaggagacg 637141 ctacacacgc tgccaaggaa gcggcattgc gtgagtttga cctgatcatt gcggcaggcg 637201 gagacggaac gatcaacgag gtcgtcaacg ggcttgcgcc tttagacaat cgtccgacac 637261 tcggtgtgat tcctgtcggc acaacgaacg acttcgccag agcgctcgga atcccacgcg 637321 aggatatttt aaaagcggca gatacggtca ttaacggcgt tgcccgcccg attgatatcg 637381 gacaggtcaa cggccagtat tttatcaata tcgccggcgg aggccgtctg acggagctga 637441 cgtacgacgt gccaagcaaa ctgaaaacaa tgctcggcca gcttgcttat tatttaaaag 637501 gaatggaaat gctgccttca cttcgtccga cagaagtcga gattgaatat gacggcaagc 637561 tgtttcaagg tgaaatcatg ctgtttttgg tcacgctgac aaactccgtc ggcgggttcg 637621 aaaagctcgc gccggattcc agcctgaatg acggcatgtt tgatttgatg atactaaaga 637681 aagcaaacct tgctgaattt atcagggtcg ccacgatggc gcttcgcgga gaacacatca 637741 acgaccagca cattatttat acaaaagcga accgcgtgaa agtcaatgta tcagaaaaga 637801 tgcagctgaa cctggacggc gagtacggcg gcatgctgcc gggcgaattc gtgaatctgt 637861 accggcacat tcacgtcgtc atgccgaagg agaaagcgga acagttggat gactaaaact 637921 tggcttggta agccaagctc agaatgttga caaaatccta aaacagtttt cgttttagga 637981 ttttgtcatc ttttcagcgt gattgaaaac ctttgaagtc taggaagggc gagcatcgga 638041 gcacagcgaa tgttgaattc gtgagcaccg aagcacaggc ctgacaacga atgcgaaggt 638101 ttgcctacac gctgaaactt ggcttgaata ggccaagttt ttctttcgct taaaactaga 638161 ggtgattata gatgaaaatg aaacccccag tagaaaaaaa tgaatactac gatgtgacat 638221 ttgaggattt gacacatgaa ggagcgggcg tcgcaaaggt ccaaggcttc ccgatctttg 638281 tgccgaatgc cctacccgag gaaaaagccc aaatcaaagt gacacgcgtc aaaaaagggt 638341 tcgccttcgg ccgcctgatt gagctgaagg aagaaagccc gcatagaacg gacgccccat 638401 gcccgattta caaacaatgc ggaggctgcc agcttcagca catgacctac gaaggccagc 638461 tcctgtttaa acagaaacaa gtcaaagacg tcttagaacg catcggcaag ctggaccttt 638521 caaaagtcac cgtgcacccg acactcggca tggaagaccc gtggaactac agaaacaaag 638581 cacaggtgcc ggtaggagaa cgggaaggcg gactcgtcgc gggattctat cagcaaagaa 638641 gccatgacat catcgacatg agcgcctgcc tgatccagca atccaaaaac gacgaagccg 638701 ttcaagctgt caaagacatt tgcgcaaact acggtgtcaa agcctacaac gaagaacgcc 638761 acaaaggctg gctccgccac atcatggtca gatacggcgt tgttacgggc gaaatgatga 638821 tcgtcttcat cacaagaaca agcgacttcc cgcacaaagc gaagatcatc gaagacatca 638881 cagcgcaatt cccgcacgtc aaatccatcg tgcaaaacat caacccaaac aaaacaaacg 638941 tcatttttgg caacgaaaca aacgtcatct ggggcgaaga atacatctac gacctcatcg 639001 gagacgtcaa attcgccatc tccgccagat cgttttatca ggtcaaccca gagcaaacaa 639061 aagtgctcta cgacaaagcg cttgagtacg ctgagcttca aggggaagaa accgtcatcg 639121 acgcttactg cggcatcgga acgatttctc tcttcctggc aaagcaggcg aaaaaagtgt 639181 acggtgtaga gattgtgccg gaagcaattg aggacgcgaa gcgaaacgcc gaattaaacg 639241 gcaacacaaa cgcagagttt gctgttggag aagcggaaac cgtgattcca aagtggtacg 639301 aagaaggcat tacagctgat acgctggtcg tcgacccgcc aagaaaaggc tgcgacgaag 639361 ccctcctgcg gacaattgtg gagatgaagc cgaagcgggt agtgtatgtg tcctgtaatc 639421 ctggcacgct tgcgagagat ttgcgggtgc ttgaggatgg cgggtacgtg acgcgcgaag 639481 tgcagcctgt ggatatgttt ccgcatacga atcatgtgga gtgctgtgtg ttgataaaat 639541 taaaagaata aatagtcaaa aatctatgct gatggaactg ttggttctct aaaacgataa 639601 ttgatttcaa tggttccatt tgcatgtact tctatttcat ctactaacaa atgaagcatt 639661 tcgggggtaa gtgtaccttc cttcatgaat ttatctaagc tctttttaaa atcaattatt 639721 tctttttcaa tcttttgaaa ttctaggtcc ttagatagtt ggtgaagggt agtttcaaaa 639781 tttgaaatat cttcattggt gatatttatg gctaattggt aatcttcttt agatataaca 639841 ccattagcaa gagagataac taaattggat ttatctctct ttttatcgtt taatttttca 639901 ttaatttcga ttatcttaga ttcgattttt tctttgtact ttaacgcttt ttcacttaat 639961 tctttaaaat aattttcctt actgaatttc aaatatatct tatttaggtt ggttattact 640021 ttatcagtta aatctatttc acttacgtaa tgatcactac atgcttttaa accatgttta 640081 ttataacttc cacaaacata accttttcga ttctttttaa aatgcattga cctcctgcaa 640141 tctttgcaaa ccgcagtatt tgtaaagaga tgtacttcag cttgaggtct ccttcttttt 640201 ctagttatta aaatctcttg tacaataaga aagtcttcta aaggtatgat tggttcgtgg 640261 cttttttcaa taattatttg gttttctagg ttaactgacc ttcttctttt actggtaaca 640321 ctcggtctat attctctaca ttgttgtagt gtcccagtat agtgaggatt ttcgagaatt 640381 tttcttattg aagatccgtg ccatttgtca gtagcgttct ttttgcgggc aagctgcgag 640441 ggactagtga ccccttcgtt atacaatccc cttgctattg catcaaagcc ttttccagca 640501 atatattctg aaaagattct aatatttact attttctctg cgtttgctga atttgagaga 640561 gatatgattg tagaacgaac tcaagaaggt aaaatgttgg ccaagcagaa tccggatttc 640621 cgagaaggaa gacccaaaaa gttcacaaag cagcaaatca atcatgcatt aacattacta 640681 gaaaatcatt cgtataaaca agttgaagat atgactggga tatcagtttc tacacttgta 640741 agagctaaaa agaagaaagc tgctgaagct ataaatggat aaatattgtg aattaattat 640801 tcaatatctt gagaaatttt tataaaagta atcaaaagtt taatggggga aacgaaatgg 640861 cgctcattga tttagaagat aaaattgctg aaatagtgaa tcgagaagat cattcagatt 640921 tcttgtatga attactcggt gtatatgatg ttccacgagc tacaattacg cgcttgaaaa 640981 aaggaaatca aaaccttaca aaacgggttg gtgaagtaca cttaaagaat aaggtgtggt 641041 ttaaggaggc taagaaagga aagctctttg acgcccttat tgatatagaa caacaagttg 641101 aatatctttc agctaagcca cgatatttat tagttactga ctatgatgga gtattagcga 641161 aagatacaaa aacattagag gctcttgatg ttaaatttga agaacttcct cagtatttcg 641221 atttcttcct tgcttggaaa ggtattgaga aagtagagtt tgaaaaggaa aaccccgctg 641281 atattaaagc agccgaacgt tttgcacgga tatatgatgt acttcgtaaa gaaaacaata 641341 ttattgagac taatagaggg ttagatttat ttcttattcg tttactgttt tgttttttcg 641401 cagaagatac tgacatcttc aaacgaaata gttttacgaa tttaattaag actttgactg 641461 aagaagatgg ttcaaatcta aataaattat ttgctgattt atttatcgtg ttagataaaa 641521 atgaacgaga cgatgttcca tcttatttaa aagagtttcc gtatgtaaat ggccagttgt 641581 ttactgaacc acatacagag ttggaatttt ctgccaaatc cagaaagtta attattgagt 641641 gcggtgaatt attaaactgg gctaaaatca atcctgatat ctttggttca atgattcaag 641701 ctgttgcttc tgaagaaagc cgtagttatt taggtatgca ctacacaagt gtccccaata 641761 taatgaaggt tattaaaccg cttttcctag ataaacttaa tcagtctttt ttagatgcat 641821 acgatgatta tacaaaactt gaaaatcttc taacacgaat cggcaaaatt aaattctttg 641881 atcctgcatg tggttcaggg aactttttga ttattaccta caaagaatta cggcgtatgg 641941 aaatcaatat tataaaacga cttcaagaac tcttgggaga gtatctttat gtaccttcag 642001 taactttatc tcaattttac ggaatagaga ttgaagattt tgcacatgac gttgcaaaat 642061 tatcactttg gattgctgaa catcaaatga atgaagaatt aaaaaatgaa gttcataatg 642121 cagtacgccc aacgttacca cttcatacag caggggatat tcgttgtgca aatgctatta 642181 gggttgagtg gactgaggtt tgtcccgcac aaggatctga agaagtatat gtttttggta 642241 atccaccgta tcttggttca aaaaaacaaa acaaagaaca taaatctgat atgttatcaa 642301 tttttggaaa agtcaagaat ggtaaaatgc ttgattatat ttctgcttgg ttttactttg 642361 gtgctaaata cgcttcaact acaaatgcaa aagttgcctt tgtatcaaca aattcagtta 642421 ctcaagggga acaggtttct atcttatgga atgagttatt caagtttgga attcaaatca 642481 attttgccta taaatctttt aaatgggcga ataatgctaa aaataatgct gcggtaattg 642541 ttgtgattgt aggttttggc ccgttagata ccaaagtaaa caagtattta tttgttgatg 642601 aaacgaaaaa gctagtttct aacattagtc cctatttaac tgatggtgaa aatattcttg 642661 tttcttctag gacgaagcca atttcagact tacccaaact gcattttggg aacatgccta 642721 atgatggcgg aggattactc tttaccatta cggaatatac agacgcaatc aataagtatc 642781 ctgaattagt tccctatttt aaaaagttta taggttcagt agagtttatt aatggtggtt 642841 tacggtattg tttatggctt aatgaagcaa aatatgaaaa aataaagtct aatcctctaa 642901 tacaagaaag aatctcaatt tcaaaaaatc acagggaaaa atcaacagat aaaggaacga 642961 ataaacttgc attaactccg tggaagttta gagatactca tgaaacaact aattattcca 643021 ttgttgttcc atctgtgtct tctgaaaata gattttatat tccaatggga ttagcaggtg 643081 cagatacaat tttgtcaaat ctaatttatg taatttacga tgcagaaatt taccttctag 643141 gcattttgat gtcacggatg catatgactt gggtaaaagc tgtagccgga agattaaaaa 643201 ctgactatag gtactctgca ggtttatgtt ataacacttt ccctattcct gaattatcaa 643261 caagaaggaa gaatgaaatt gaagaagcaa ttcttgaaat tcttgatctt cgtgaagagc 643321 agggtggtac attagcagag ctttataacc cttcaacaat gccaattgaa ttaaaagtag 643381 cacatgaaaa gttggatgga attgtagaaa gagcgtatcg tcaaaaacaa tttgaatctg 643441 atgaagaacg cttagaagta ttgcttaaat tgtatcaaga aatgacagaa cggtaggtgt 643501 aaggtgtatg gaaaatataa ttgaaattaa ttataaccaa actggtaaaa gtaagaaaac 643561 aaatgaatac ggtatgcgtg aaatgcaggc aagagctttt gaaaaacgta actcacaata 643621 tctcttagtt aaagcaccgc cagcttctgg gaaatctaga gctttaatgt ttatcggttt 643681 ggataagctc ataaatcaag gtttgaggaa agtgattgtt gctgtacctg aacgctctat 643741 aggttcttca tttaaaaata cggatttaaa aagttatggt ttctttgaaa attggaaagt 643801 tgatcctaga aataatttaa ctgttggcgg agataactct aaggttaaat cttttgttcg 643861 ttttatggaa tcggacgatc aggtgttaat atgtacgcac tctactttgc gatttgcgtt 643921 tgaaaaaatt gatgataaag catttgataa ttgtttactt gcaatagatg aatttcacca 643981 tgtatcggca gatgtcaatt ctcgattagg tgaattgtta agaagtatta ttcataattc 644041 atcagcacat attgtagcga tgactgggtc gtatttccgt ggagattctg taccaatttt 644101 attaccagaa gatgaggaat tatttgacaa ggtaacttat tcctattatg aacaacttga 644161 tggatatgaa tatctaaagg gatttggtat aggatatcac ttctatcaag gccagtacac 644221 atcagctatt aatgaagtat tggatacaaa taagaaaaca atcgttcata ttccaaatgt 644281 aaactcaggg gaatcgacaa aggataagta cgatgaagtt ggtaagatac ttgatatgat 644341 tggtgaagtt gaatatcaag atgatgatac tggaattatt tatgttaagc gacattctga 644401 cggtaaaaca ttgaaaattg cagatttagt agatgaccaa gttggaagag aaaatgtcgt 644461 tgcgtatttg cgtaatattg aagccctaga cgatttagat ataattattg ctcttggtat 644521 ggcgaaagag ggctttgact ggccgttttg tgaacatact ttgacagttg gttatcgtgg 644581 ctcacttaca gaaatagtac aaataattgg gcgctgtaca cgtgatagtt acaataaaac 644641 ctatgctcaa tttaccaacc taatcgcaat gcctgatgca aaggatgaag tagtgactta 644701 tacagtgaat acaatgctta aagctatttc tgcctcactt ttgatggagc aggtccttac 644761 acctgacttt aaatttaaac gtagaagaaa tgaaagtgaa aaatcttcta ctacaggaga 644821 attattcgtt aagggattga aagaaccatc aacagaaaat gtcaaaaaga ttattgaaaa 644881 tgatattaat gatttaaaag caaaaatcat gcaagattca caagtccaaa aaacatttag 644941 tggagaagta gatcccaaag tattgaacaa agtgttgatt ccgaaagtta ttcaaaaagt 645001 atatccaaat ttatcagatg aggaaattga ggaagttaga cagcacgttg ttctagatac 645061 agttatgaaa ggtgctaagt ctgaagttgt aggaagtaaa gaatttataa gaatggcaga 645121 taagtttata aacattgagg atttagatat caatctgatt gattccatca atccgttcca 645181 aaaagcattt gaggttctat cgaaagaatt gaactcacca gtgctaaaac tgattcagga 645241 aactattgat gcaaaacgta ttaattttga tgaagatgaa ctagtattca tatggccaaa 645301 ggtttaggaa ttttatcgtt caactggtag aagacctgat tcaaaatctg aagacccact 645361 tgaaaggcgt atgggtgaag ctgtattata catgcaagag cttaggagga aacgtgaaaa 645421 tggcaagtaa tagataccat tctattaatg aaatcatgga aagtcagctg ttttaccaaa 645481 tcacaacacc acctaagaaa acacaaaaag cccagtatga tcctgaagtt gaaaagtttt 645541 tggagattat tgaattcgtc aaagaaaatg ggcgagaacc ccaaaaagtc cctactgatt 645601 taactgaaag aagtttagca agtcgattaa ttgggattcg gaaagatcct gatcgtatgg 645661 aatatttgaa agagtatgat gaaattggat tacttgaagt aagatcgaag gaactaacaa 645721 ttcctaaaat ttcttcaatt gatgatattc taaaaagtgg cttatctgca ttattaggtg 645781 ataatttaaa taatgatata actaggtcaa tttttgatac aagttcactt caaaaggtta 645841 cgacaatgcc tgaatacgtt gcaaagcgta aaaaaataaa agattttgga aagtttgaag 645901 agctattcaa gaagtgccac aaggaaatta cagagggtaa acgaaaaatt ttaactttca 645961 aaaatgaaca agacatacag tcaaatagtt tttatatatt aaaaggagtt cttctttatg 646021 ttgaagatgt gggagaacgt aaaaaagcaa agggaaaaac caatgctaga cttcgatgta 646081 tatttgaaaa tggaacggaa tcagatatgt tactacgttc cttatcagcg gagttatata 646141 aacatggtag acgtgtgacc gacaatgaag atacattgtt ggataatgtt agagaagatg 646201 atgtttcgac tggctttatt tacgtactaa aatctttgag tacagatccg caaattagtt 646261 ccattaagaa tttatataag atcggtttta caactggttc agtagaaaat agaatcagga 646321 atgcagaaaa tcaatcaact tatctttatg ctccagtaga aattgtaacc acatatcaag 646381 tgttcaatat gaatgctagc aaatttgaga cggcaatcca tcatgcgcta gcaaataata 646441 atttggatgt ttctattttg ggggcaaatg gaaagatgtt agttcctaaa gagtggttcg 646501 ttgtcacact tgaagattta caagctgtaa tagatgagat tgtgatgatg gttcatcttt 646561 atgactaaat tagtatatta ggattttagt attaataata attttatagt agactatgaa 646621 aaaatttgat gccataacaa taacttgttc cgctttggag tttgtcacaa ttgtagaatt 646681 atgtgttgcg agtattaata ggaaggggtt gagcgaccgc aaaaaaaatt ttcggtgctg 646741 tccgcaaaag ggagtttggg tgttttgcgt tatatttggt tgtgtgaagg ttagcggaaa 646801 ctcaattcgt gaagttagga ttgcggttat tacgactgag tagtttcgtc atactctttt 646861 agcagttttt ctgtcttatg catttctttg agcatcggat tcatgtagtc gttagctgat 646921 tctagatatg ctctcgtcag agtgtctagt ttatttctaa ctttagagag gtcttcttcg 646981 aattttccat ccgatgattg aaggataaat tcttttgcct cttcatatct ttttaatatg 647041 tttttcacca ttggagttgg attcttttga tttattgttt ttattacagt gattgttaaa 647101 tttatttgtt ttattaattc ttttcttact gtcaaggtga tgctcctttt aaatctctat 647161 tctatttgag agttgctata tctgtttaat ggtttgatag actactcatc tttataattt 647221 agagcaattt ttacaacttg ttccgctgtg taatcttcat tgctccagaa aattaaatca 647281 cttggtgccg gataaggaac atttttctct aataaatcga gatattcact gactttctca 647341 tcatctaatg ttgggttcat taattccttt acaagaaaga tcaactcttc ttttgtcagt 647401 ttatccattg tttgccctcc aatagattgt atctccattg attttacaaa tgactttatt 647461 tcttctgata atgttatagg ttgtttgcat aatgatagat aattgtcttg agaaaagtta 647521 gtctcattat agagtttatt aattgtattt ataacaatat attcatatgg aaaacctcta 647581 aaatatcttt attttagatt ggtttataaa aaatagctca gcagagtagg gctgagccat 647641 tttttaatta tagaccgagg taactaatta caaattcttt atcatcctca tcttcaggca 647701 aaataccaag gtttttatat tcccatattg cgattctttc atatccatct aattctgagg 647761 ctaaaatatc atcataatta taatctaatt ggaattctcc gctacgatcc aatgttagtg 647821 taaggttagt ccaaacatca tcgttattat ttctgtgttc agttcttaat tcttcaaaaa 647881 gttctcttag ttctcttaac aacgtcttga aaatatcctt gcttacgttg taatggctag 647941 gtatatcttg tgaataaata atttgattat tttctggtgt tctgaaatga aaaagaacca 648001 ttgtggaatc atctaatact tctgcataaa gatatatctt tgtccattca ccaggtatga 648061 tgtcattgag tttttctcca ataagttgat acaaatcttg catcttccta gtttccattc 648121 ttctaacccc caggctgatt tttaatagag acgcttattt cttttctgct cccaattttg 648181 taggttacat cgaaatatga tggtctaagt gaatccccag aatagactgg ttctatttga 648241 actgctactt ttttaggtgg ttttttgctt agggcttttg cccactcctg ctccatctca 648301 taccatttcc caccgctcct attaatctga gaattcatcg gcacgatatt gtcaaactgg 648361 cctgagcctt tgaattgggt ggcgattaaa tggccgccgt catcgtcagg ctttcggtcc 648421 tggggctttc cagcattcgt ttgtgcatat tggtttcgtt tcgcttctcc cagctgcaag 648481 tctgctttga cacttgtaat tctaccatag ttgtcagtcg tgtacgtgta gccttctttt 648541 gttttgtaga tgatattagg cttcagcact ttctttctgc tccatcttgc gaaatgctcg 648601 ccgtatttga cggttaccgg cggtacatgt ggcgctggag ttcgtcttcc gcttgatgac 648661 gttccgtatg gtttcggcag gatgaccttg gcgaattttt gcagtccttc tttaagcgtg 648721 accccgttga ctgcgttgta aggaacgcct gccggcacta aatcatgacg gggatgatac 648781 gggagaatat ccgcaagtgt gagatctccg atttgattta acttggtttt gacgtgtttt 648841 tttgatactt caatgcctgt gtttactttt tgtttgatgt gatcaacggt ttgttttgag 648901 actgttatgg ctttttgggc tgttgctgat ttgcttgctg ctgttttgac tttggtcgtc 648961 actttggcgg ctgtgccagt ttttgagacg gctcctacgc cttttgtgcc gacaattgat 649021 gtgacaacag tgccaaccgc atatgacacc catcttgctc ttgagtaggt gtcaccattc 649081 accatgtctt tttgatacga ttcttcgatt gccgctgaaa tggcttcata cgttttgatc 649141 gggtgagcca tcgctccggt aatcgcttca acggttcctc ccggatctgt gaccatatcc 649201 cacaggccta cgaccgcgtc tttcccggaa tcataaaggc cgacggcaac ccctttgaag 649261 cctgcttcaa gctcacgcgt gttttcaatt tgggtgaagt atctctgttg ttcagctgtc 649321 agattttcat agccgatcgt ttttgccatt tcgtagaatt catcggcatc tgcataatcg 649381 tagtttttca gtctttcttt cagtttctca atctcgcgtt ccttcgcttc ctctttctta 649441 atcttcaagt aagcctcagt ccgcttttca atgtcgcctt ttttcttatg tatgtcactc 649501 tcacggtacg ccttggcgtt gtagtggatg ggtgtggcgt ttttgccttt acccgttgct 649561 tcttggagct tttggaagtc ggatttgatg aattgttcgt ttggttcaga cagggcgtat 649621 tctgttttca ggtcttcgtc caaggcgtcc aatttttcca gtgttttttt gcgtttgtcg 649681 ttggcatcgg ccagctcgtc tttgaaggtt tctgttgaaa acaggtcgag cgggaggatg 649741 tcgtcgatat cgtttaggat gtctttcatc gcttttttct gttcggacat gatggattta 649801 gattttttat tggcatttgc cagttcgtgc tccaggaagg attcttcgat gtatgcgtct 649861 gagaggcctt tgtcttcggc ggctccggcg atgctgttga aaaatgcgat tttcatgtcg 649921 atgtagtcga tccactggtc ggcgacgccg acgtggtcgt gatagaatgc cttgatgttg 649981 ctggcgcctt ttcctgagaa ttcactgtca ctgagatcag cgactccttt taacgctttt 650041 ctcaagttga ccatttgcgt tcttagttct ttgtactctt ttgcacggtc tgtcgcttcc 650101 gaaagcagtg ttttcgcttc aaatactttc atgaccattt cccttctttt gttcgctcaa 650161 tatcaaaatt ttaccacggg tcgggataag gtgggggtga gaacgtgttt tggtggaaaa 650221 atgagtcatt tggcatgtgt ctttattcgt ggagggattg gaggaaacat ggtcgaaatg 650281 atattgattg ctacacattt tttggaagtt tgtattctat attgtttttt aaggagcatg 650341 ttgatgacga aaaaacggat tacatttggt ttattagttt taatggtatg tgtcatcctg 650401 tttgttctgt atgttcagtt acgcaataaa gatagtattc ctgtccaatc ttccgccatt 650461 caccccgaag aagaccgcat cttttttatt tactccaatc ctttcataaa agaaagcgtg 650521 ctgctttcaa cctctacagg cgaacggttt aacaggcgta cgtttaaggt ggcggatgtg 650581 ccttatattc aaacgaaatc ttatgcatca acagaccttg tattattggc ggaacacgag 650641 cctttttact acacgctgga gaaggatgtg atcaaagagc atccgctgtc agatccattt 650701 gcgttttggt atgaggggaa ggatgtcact attgaggcct ataatgttga tacgacggga 650761 aatgagatcc acataaacga cagaaaaacg aaaaaggaat atacccttac cttgcctccg 650821 cttgtcacaa tgggggccag tgatgagaac tttatttata tcattcaaag catgtctatt 650881 tacgtgattg acagaaaaac agaggaaatg attgagaccc tgagcttagc ctcatacgct 650941 gatcaattcg cagactcgga ggaatttatc gtcgcgagct cggatcataa attgactgtg 651001 attgaaaaag ggacatggaa gacgacatat attgcgtatc ctgaagatct tgaatatgca 651061 gatactgtgt actatgacaa agaaagcggc agtttttacg tggcgtacga ggacaaagag 651121 ggtggagcga acttgctgga atatggggag gatttttcta ttcacacata cagcttgaaa 651181 ttcccttata tggaggcgaa gtttaagggg aatctattgt atatagttgc ccaggaagag 651241 cataaaaagg gcatcggcgg atacgtgggt gtgtttgata tccattctaa ggagatgctt 651301 tatcagtttg atttgcctga ggaacaggtg aaggttcagg attttgttgt ggttgacaat 651361 aagtgaatac tatatgaaat agaatgacaa agacccttgc ataaagggtt cttttttatg 651421 aaaaaaacaa attgacagga tgaaaaaaca atttcttcct tctatattgt tttcaaaatt 651481 tgggattgat agaatatgac atatctcata gagaaggagg gaagccgttg agtcaagcca 651541 taccgtcttc gcgtgttggt gttaagatta atgaatggta taaaatgatt cgccagttca 651601 gtgttccgga tgctgagatt ctgaaagcgg aggttgagca ggacattcag cagatggaag 651661 aagatcagga tttactgatc tattattctc tgatgtgttt tcggcaccag ctgatgcttg 651721 attatttgga gccgggaaaa acatacggga atcgccctac agtgacagag cttcttgaaa 651781 cgatcgagac ccctcagaaa aaactcacag gtcttttgaa atactactct ttgtttttcc 651841 gcggcatgta tgaatttgac caaaaagaat atgtggaagc gatcggatat tatcgcgagg 651901 cggagaaaga actgccgttt gtgtcagatg atattgagaa agcggaattc cattttaaag 651961 tggcagaagc gtattatcac atgaagcaaa cccatgtgtc gatgtatcat attcttcaag 652021 ccttggacat ttatcaaaac catcctctat acagcattag aacgatacaa agcttgtttg 652081 tgatcgccgg caactatgat gatttcaaac attatgataa agcgctcccg catttagagg 652141 cggcgctgga attggcaatg gacattcaaa atgacaggtt tatcgccatt tctctattga 652201 acattgcaaa cagctatgac agatcaggag acgatcagat ggctgtagaa catttccaaa 652261 aagcggcgaa agtaagcaga gagaaagtgc ctgatctgct tccgaaagtc ttgtttggat 652321 taagctggac attatgtaaa gcgggccaaa cacagaaggc gtttcagttc atagaggaag 652381 gattagacca tatcacagca cgttctcaca aattttataa agaattgttt ctgttcttgc 652441 aggccgtgta caaggagact gttgatgaac gaaaaattca tgatctttta agctatttcg 652501 aaaaaaagaa cctgcacgct tacattgaag catgtgcccg gagtgctgcc gctgtttttg 652561 aaagcagctg tcactttgaa caagcagctg cgttttatcg gaaagtgctg aaagcccaag 652621 aagatattct aaaaggagag tgtttatatg cctattaaga aaaaagtgat gatgtgtctg 652681 gctgttactc tagttttcgg aagcatgtcg tttccaaccc tgacaaactc cggtggattt 652741 aaggaatcga cagatcgaaa tacgacgtat atcgatcatt ccccttacaa acttagtgat 652801 cagaagaaag cccttagcta gggctttttc ttgctttacg gaagacgttc cattttccac 652861 atcgcggcat tccttctatt tctaacgcaa gacactcgaa acaaccaaac catttgaggt 652921 ataatggata aagtgaataa cagtatttag attgatatat atgaaagaga gtggaacatc 652981 atgggccgta agtggaacaa tattaaagag aagaaggcgt ctaaggacgc aaatacgagt 653041 cggatttatg cgaagtttgg ccgtgagatt tatgtggcgg cgaaacaggg cgagcctgat 653101 ccggaatcca accaggcgct gaaggttgtg cttgaacgtg cgaagactta cagcgtgccg 653161 aaaaacatca ttgaacgtgc gatcgagaag gcgaagggcg gagcggaaga gaattacgat 653221 gagcttcgtt atgagggctt cgggccgaac ggatcaatga ttatcgttga tgcgctgacg 653281 aataatgtaa accgtacggc gccggaagtg cgtgcggcgt tcgggaaaaa cggcggaaac 653341 atgggtgtga gcggatctgt tgcttacatg tttgacgcga cggctgtaat cggtgtggaa 653401 ggcaaaacgg ctgacgaagc gcttgaaatc ctgatggaag cggatgttga tgtacgtgac 653461 attttagaag aggatgacag cgcgatcgtg tatgccgagc ctgatcaatt ccatgcggtg 653521 caagaggcgt ttaaaaacgc gggtgtcgag gaatttacag tagcggagct gacaatgctt 653581 gcgcaaagtg aagtaacgct tccggatgat gcaaaggaac agtttgaaaa attgattgat 653641 gcattagaag atttggaaga tgttcagcag gtatatcata acgttgattt aggtgagtaa 653701 ggagtgagca ggctgttatg gcctgctttt tttgtcccgg aaattgtttt agctgtatgt 653761 aggcggccgc ctatacgatc tataagatat tctcatactc tggactgtaa cctatgtgaa 653821 ggagagagta aatatgactg atacaagaca tatgtatggc ggacctggtt ttggtcatta 653881 tcagggcttt ggtattggcc acccgggcta tggcatgcaa agcacaggct atccgggcta 653941 tggcatgtat ggaggccacc cgggctatgg catgcaaggc tacccagatc acggcataca 654001 tggaggagtc ggcggctatc cgggatatgg tgggtacggc ggttacccaa gcggcggcta 654061 tggaggctct ccgggaactg gaagctatcc gagcatgcac catgaaaatg atggccatca 654121 ccactattat caccatcatc atgatggaaa agataatctt catcaccatc atcaccatgt 654181 tggaaaggat aatcatcacc accatcatga tggtcattat ggccaccatc atcaccatat 654241 gggccactgg ggaaaagacg gttataaata aagaagatga tgataaaaag aggacactct 654301 tgcagatcaa gagtgttttt ttagcttttt tcttgactgt tcagtctgga aaatggtaac 654361 atttgtttca ggaggtgatc attttttggg gaggaataaa gaatttgata cggcgcttgt 654421 tcttcacagg gcgatagagg tttttggaga gtatggctac gaaggaacgt ctcttcagga 654481 tctgctctct catttaggca ttgcgcgcca aagtttgtat gatacgtatg gaacgaagcg 654541 tgatttgttt ttgtccgctg tgaaatcgta tcttgaaggg aaaaacgctg ccgttatgga 654601 aaggcttgaa gcgccaggat ctgtaaagga agccattcgt gatatttttc aggagggtgt 654661 caatgccctg agggatccgg aacgggcgaa ggcgtgctac attattaaca gcgcgattga 654721 acagatcccg catgaccctg agcttgcccg gtattttgaa agacaatcca agcagcttga 654781 ggacgctttt tatcacgggc ttttaagagc gaaggatcaa ggagaattga atggcgaaga 654841 tactgatata tctgcgcttg ctcggtacct gaatcagagc aggctgtcac tgacatttat 654901 tgcaaaagtg acggcagata tggatcggct tcaggaccat gttgacgtga gtttatcagt 654961 gcttgattaa catgtggtaa aggattcttt gcccatgtat gtactttttg gactgaatag 655021 tctagaaata aaaatgaggt gatgatgaat gttgatgaat gagtttgaaa aagcatgtga 655081 aacattgaga aagtttatgg cttatatgct tgagaaggac atgaagagct ggacggagct 655141 ttgggatgag aatgctgtat ttgagtttcc ttatgcgccg gagggatcac caaaaagaat 655201 agaaggaaaa gcggccattt acgattatat taaagattat cctaagcaga ttcatctttc 655261 ttcatttacc gctccgacag tgtaccgttc agcagactcg aatacggtga ttgcggagtt 655321 tcaatgtgac ggccatgtga ttgagactgg actgccttat cgccaaagct atatcagtgt 655381 catcgaaacg agagacggcc gcattgtgcg ttatagggat tattggaatc cgcttgttgt 655441 aaaagaggcc tttggaggat catttttgca aacagaggag agtgggaaat gatgaaacag 655501 aatccgattt taatcacggg cgggaccggc acagtcggca gccgaatcgc cagccgttta 655561 ataaagctgg gatacagagt gcgtattgca agccggaaaa agggcgcgct tgctgatgct 655621 gagtatgtgt attttaattg gaagtacgcc tccagtttta cgcctgctct ggaacaggta 655681 aaacagatct atcttgttgc tccggtcggt gtatttgatc cggctcccta tgtgcttccc 655741 tttttaaagg aagcaaagcg tctcggcgca aagcgggtag tgatgcaaag tgcgtctgtt 655801 gtctccgaga acggtcccgt gtttggcgcg cttcaccagg cagtgcgcga gtttccagaa 655861 tggacggtgc tgcggccctc atactttatg caaaatttca tcaatgtcca gcaccgcatg 655921 tctattcaaa cggaggggcg catcacaacg gcttcgggtg aaggaaaact tgggtttatt 655981 gacgctgatg acatcgcaga aacagccgtc agggctttga ttgatgatgt tcctcatcaa 656041 acacatcata ttctgacagg tcccgaggcg ctgagctatg ccgaagcggc ggagatcatt 656101 ggagctgcgg cgggacgccg ggtggagcat gtcagcattt ctcgttccga gctgcagcat 656161 aaaatggagg caggaggttt gcccgcggat tatgcccatt ttatggcgaa gcttgatgag 656221 gcaattagcc atggtgcgga acatcgggta acggatacag tgaagcgtgt gacgggaaaa 656281 gaacctcgtt cgctgtcaga gtttgcggct gctcatgctg catattggac ctcattttgg 656341 actgaatagt ctagaaagac cttcggcgct tccgaaggtc ttcttattga aaaagctaag 656401 tcgtgtttta gtcataatca tgcctcctgc ctcataccta ttaaggtcat tgtttttgag 656461 aaaggaggag ccggaatgaa ggatatgcag ccgtttacgc ctgtcaaatc atatacgccc 656521 tttcacagcc gttttgatcc ctgtccgccc atagggaaga aatattacag aacgccccct 656581 aacctttata tgacctttca gcctgagcac atggagcagt tttcgccgat ggaggctttg 656641 aggaaaggca ccctttggaa ggatctctat gatttttatg aaaaccctta tcgaggggga 656701 gacgcacatg gcaaaaaagg ttgacgccga atattatcgt cagctagagc aaatacaggc 656761 tgctgatttt gtgcttgttg agctgagtct ttatttaaat acacatcctc atgatgaaga 656821 tgcgttgaag caattcaatc aatattccgg ctattcaagg cacttaaaaa gacagttcga 656881 atcctcttac ggaccgcttc tgcagttcgg caacagcccc gcgggcaagg attgggattg 656941 gggaaaaggg ccatggccgt ggcaagtata aggaggaatg cctgaatgtg ggtgtatgaa 657001 aagaagctgc aataccctgt caaggtcagt acgtgcaacc cgacgctggc gaagtatttg 657061 attgagcagt atggcggagc ggacggcgag ctggccgcgg ctctccggta tttgaaccag 657121 cgttatacga ttcctgataa ggtcatcggc cttttaacag atatcggcac ggaggagttt 657181 gcccatttgg aaatgattgc gaccatggtc tataagttaa cgaaagacgc cacaccggag 657241 cagctgcgtg aagctgggct tggcgatcat tacgtcaatc acgacagcgc gcttttttat 657301 cataatgcgg cgggcgtgcc gtttaccgcg agctatatcc aagcgaaggg cgatccgatt 657361 gccgatttat acgaagatat tgccgcagaa gaaaaggcgc gggcgacgta tcaatggctg 657421 attgatattt cggatgatcc tgatttaaac gattccctgc gttttttgcg tgagcgtgaa 657481 atcgtacact ctatgcgctt cagagaagcg gttgaaattt taaaagaaga acgggataaa 657541 aagaagattt tctaataggc agattggcct ctctttcata caccctttta catacagaga 657601 aaatggtctg tttttgcagt ttggtctgca ttataatcaa ggtgtgtgtg caagcttact 657661 ttttgattgg gaggccttta tgacagcttt taagattgag aacgaaacga ttgcagatgg 657721 attttacgcg tgtccggccg tctatgagga tgcagaatcg attaccgggt tgctcgtccg 657781 aacagctgaa tggctccggg atcggggttc taaccaatgg agcggacttc tcaaagggca 657841 agatatacat gatatcacgg ggtcaattga aaagggacat gtgtttgtgt ttaaaaaaga 657901 tgaagagctt gcggctgtcg tgatgctgct gcctgcaccg agcgagtggg accggacgct 657961 ttggggagac gatgggcatg aggagtccat ttatttacac cgcctcgcag taagccgccg 658021 gtttgcggga caggggcttg gagcccgcgt ccttcagtgg gcggagacgg gcatacactt 658081 tccggaaaaa acgcggatcc ggcttgactg tgtcgctgat agtgacgccc tgcattcctt 658141 ttatcggcgt atgggatatg aattcatggg tgctgatgcg tccggatatc atttgtttga 658201 gaaagagatt acggcagaat aagcgtcctt tgcagggggc ttttttgtct ttttctaaaa 658261 gggaggcagg cgatgtgtgg tcaatattat ttgtgacagg gattgtgacg gcttgtctgt 658321 ttgctggcgt atccgtattg atgcggatga gatttcctga caaaagtcgg ccggaatgga 658381 tgttggccgg gctgatcgtc cttggtgtgt ttgcgatctg gtacagcctc gtgtatgtac 658441 gcggctggga aggggctgcg ctcggaatgc ttggattcaa tgtcattttc ggagccattg 658501 ccggatattt gatcgataag gccatccggc gttacaggaa aagataaggc tgctgccgtc 658561 tctcaacagg tcgaaatttt cacagaccgg caggaatttt ctttcgaaag gagaaataca 658621 tattacttta aaatgaaagc gttttccaaa gcaggaaggt gatgttgatg atacacagtg 658681 tggcaaatgg gctgaatcat ttttgtacgt gggtgatgag actggcctat ttgaatgtgc 658741 tttggatttt gttttctctt gcaggcctgg ttgtatttgg gctgatgccc gctactgccg 658801 cgatgtttac agtggcgaga gaatgggcga aggggaatac agatgccccg gtgttttctg 658861 tcttttttcg gacgtttaaa aaggaatggc gggcatcaca gatcctcggg cttatcgttg 658921 tgacggctgc cctgtttctg tttgcggata tgcggatagc ggctcagatg gaccagcctg 658981 tgctcgtcaa tgtattcgtg agcattagtt tgattttcgc gtttgttgtg ctgtatgtgt 659041 tcccggtatt ttctcatttt gacgtaaaaa tcagagaggt gctgagcatc agctttttca 659101 ttgccttcag tcgtccggcg gtgacgcttt tgatggcagc gggcgctgtc ggtgtgcttt 659161 gtctcgttct gtttcatgtc acgtttctat tgtttttcag cgggagttta ctcagcctga 659221 tcttaacgaa gctgtccttt aaagcgtttc ggtcaatgga tcagcggcag gagaaagaaa 659281 aggcggcatg aagaaaagag ttgctggctg gtacaggcgg atgaagatta aggataagct 659341 gtttgtgttt ctatcgttga ttatggccgt atcctttctg tttgtataca gcggggtcca 659401 gtatgccttt catgtgtatg atgagcagat ttaccgcaag tcctcggagg tgcttcggat 659461 gtcttctgaa aggatcgaag acgagctgaa gaagatagag gatgtgtcat atgaaatcat 659521 tacagacgaa cagattcagc gcatcctgag catgcaaaat cgggatgata cgtatgatca 659581 atatcaaatg aagcaggagc tgtgggatca gcttgcggga tatgccagcg atgaaaagta 659641 catcgattcc attcatgtga ttgatgcccg cggctcagag tattcagccg gaagcagttc 659701 ttcagatctt ttgcagcagg agcaggaaga ggtatttaag cgagcgaaag cgaaaagtgg 659761 aagaaatctt tggatgacgc tcggcgggtc agaccccgtc ctgatttcag cacggcagat 659821 caggtcctat caccagctga gtctgaacgg cttgggcatg gtactgatcc aggtcaatgt 659881 aaaacagatg attcgtgatg tgccgaagga ttggggcgat tcagtcggag acattatgat 659941 tgctgaccaa ggcggtaatt tggtgtatac ggcacatgca tcagcgcatg ttcctgaggc 660001 agcaaaagag acgttgaagc accccggtta tgacttgata aaaaagaatg gcaaacgtta 660061 ctttatttct tatcttcaat catcctacca aaattggagc tactataacg ttatcccctt 660121 tgatcagatg ttcgcaaaaa tttcctttat gaaaacagtg atcggcacat gctttcttct 660181 ctttttctgt gtggttttgc ttttcggaag gaaaatcgcc aacagcatca cggagccgat 660241 tgaacagctt gtgaccgcga tgaaatcggt acagcacagc ggcattgaag caggtgtgtc 660301 gctttctctg ccggaacata cacaggatga ggccggcatg ctgaaccgcc attttactgt 660361 catgatgaaa cggattaatg agctgatgga agaaaatgtg gaaaaacagc tcatcattaa 660421 agaaaccgaa ttgaaagcac tgcaagccca gatcaatccg cattttttat ataacacgct 660481 cgagtccatc aattggctgg ccaaggcgaa tcagcaaaag caaatctcaa aaatggtgga 660541 atcgctcggt tttcttctgc gaaacagcat acatatgaag aaggatatcg tgaccattca 660601 ggaggaggcg gacattgtac gtcactatat gaccattcag cgatttcgat ttgaagagcg 660661 cctgaaattc acgttggata ttgacgatga ggtgaagcat tgcctcattc cgaaactgac 660721 gctccagccg cttgcggaaa atgcgattca atacgcgctt gaacccttta caaggccatg 660781 cgccatccgg attcaggcga aaaaggcgaa gggctgtgtc tgtattacgg tcgaagataa 660841 cggccctggc atggatggac ggattcttga atcaacgggt ggaagaggaa tcggactttg 660901 gaatattcgc gagcgcatca gcctgacatt cggagagcca tacggattgc ggattcatag 660961 tgagcatgaa aaggggacga ggattgtgat cacaataccg tgccgaaatg aggtggtgtg 661021 atgtataaaa tactgctggc tgatgatgag aggattatcc ttgatggaat ggcgggaatc 661081 attgagtggg agtcgcttgg cgcctcattg atcggaaaag cgcagaacgg acatgaagca 661141 tatgaaaaga ttgtacataa gcagccgcat atcgtcatca cagacgtcaa aatgcccggc 661201 atggacgggc ttgagctgat caaaaaggtg tcagccgtca gcccgtcggt gcaatttatc 661261 gtcctgtccg ggtttggaga gtttgagtac gcaaaggaag ccatgaaata tggggtgaag 661321 cattatttgc tgaaaccctg caatgaacag cagattatca gctcgctgga ggaaatcatt 661381 gctgagctga agcggcaaga tgtgcacaaa aagaaaacag cccatctgaa acacgagctg 661441 gaccatatcc gttcctttgc agccgatcaa tacttggaag gcttgatcgc cggtgtggcc 661501 cagctttctc cgccgccttc acttgccgga aaaaagatcc gcctcttgat cttaaaaggg 661561 gaacaatcta ttgatgctgc agccagagag gcactcggat cggcactgac agcggtttgc 661621 agcagcggtg aatggaccgt gctcgccgta gaggagaacg ccgctgaaaa ggtggcggag 661681 gtttttgcgg accgcaagat ggccatcagt caggcgggag aactccggca cgcggggcag 661741 ctgtttcgtg acacagctga agcgtctggt gacctgcatg ggagcgcagt gatttcaaaa 661801 atgatcaggc ttattgccga cgagctcgga aatccgaatc tgtccttaaa atgggcggcg 661861 aaggatatgc tgtttatgaa tcctgattat ctcgggaagt tatttaagca ggaaacaggc 661921 gagaaatttt cccaatatgt tacacgggtg cgtcttgagc atgcgatgaa gcagatgaaa 661981 ataaggaggg acgtgagcgt ttcagaaatt gctgaagaaa tcgggtttgg cgataatccg 662041 aagtatttca gtcttgtttt taaaaaatat accggtctga caccgtcaga attcagaaga 662101 aaacagggag gcgcttccgc aggatagcca tctctgtttt tttgactttc gccactgttt 662161 tttgagtgtt tcgccctatc cgaacgcttt aaaataaaat gtaagcactt acattaaagg 662221 ggggattggt ttgaagaaga tttgttacgt gctgttatcc cttgtctgcg tctttttgtt 662281 cagcggatgt tcagcgggtg aagaggcctc gggaaaaaaa gaagatgtta cactcagaat 662341 cgcgtggtgg ggcgggcagc caaggcatga ttatacaact aaggtaattg aactatacga 662401 gaaaaagaat ccgcacgtcc atattgaagc ggaatttgcg aactgggatg actactggaa 662461 aaagcttgcg cccatgtctg ccgccggcca gcttcctgat gtcattcaaa tggataccgc 662521 ttacttagcc caatacggaa agaagaacca gctggaagat ttaacgccgt atacaaagga 662581 tggaacgatt gacgtcagtt caatcgacga gaatatgctg tcgggcggaa aaatcgacaa 662641 taagctttat ggatttacgc taggtgtcaa cgtgctgtct gtgattgcca atgaagattt 662701 gctgaaaaaa gccggtgtgt ctatcaatca ggaaaactgg acgtgggagg attacgagaa 662761 gctggcgtat gatcttcagg aaaaagccgg tgtctacggt tccaacggaa tgcatccgcc 662821 tgatattttc ttcccttatt atttgcgcac aaagggtgag cgcttttata aagaagacgg 662881 cactggcctc gcgtatcaag atgatcagct gtttgtcgat tactttgaac ggcagctgag 662941 gctagtgaaa gcgaaaacgt ccccaacacc tgatgaaagc gcacagatta aagggatgga 663001 agacgatttt atcgtcaaag gcaaatcagc gattacatgg aactactcca atcaatattt 663061 gggctttgcc cggctgacag actcgccgct gtctctctat ctgccgccgg agcaaatgca 663121 ggaaaaggcg ctgacactga agcccagtat gctgttttcc attccgaaaa gctctgagca 663181 taaaaaagag gcagcgaaat ttattaattt cttcgtgaat aatgaggaag cgaaccagct 663241 gattaaaggc gagcgaggcg ttccagtctc cgacaaggtg gcggatgcga ttaaaccgaa 663301 gctgaatgag gaagaaacca acatcgtgga gtatgtagaa accgcgtcaa aaaacatcag 663361 caaagccgat ccgccagagc ctgtgggaag cgcggaggtc atcaagctgc tgaaagatac 663421 gtcagatcag attctgtatc agaaggtatc gccggaaaaa gccgccaaaa cgttccggaa 663481 aaaggccaat gagatattag agaggaataa ttgacgggaa atggggctga cgcaatgaaa 663541 aaaagccgga gtataagaaa agacaatctg gcgggatatg cttttatttc tccgtttatc 663601 atcgggttcc tatgctttac ggtgattccg atgggggcgt ccctgtttct gtccttcacg 663661 agctatgact tgtttacggc gccgaaatgg atcgggctcg acaactttaa ggaaatgttt 663721 acgggtgacg aaaagtattg gcagtctctg aaggtgacgt ttacgtatgt gcttgccggg 663781 gttccgctcc gcctcggctt cgcgcttttt atcgctgtca ttttaaacaa tgcagcaaaa 663841 ggaacggcca tttacagaac gctcttttat ctgccttcga tcatcggcgg gagcgtcgcc 663901 gtggcgatta tgtggcgcaa tatttttggc aatgacgggg tcatcaatgc gctgctgttt 663961 tttgtcggga ttgatcaaaa aattctttgg taccagaatc cgacaagtgc gctgtggaca 664021 ttgattctgc tgtccgtctg gcagttcggg tcgtcaatgc tgattttttt ggccgggctg 664081 aaaaacattc cgtcttcgta tttggaagcg gcaagtgtgg atggggcaaa tcgggtgcag 664141 cgtttcttca agatcacgct tccgatcctt acaccgatta ttttctttaa cctagtgatg 664201 cagacgattt ctgcttttat gacatttaca cctgcctata tcatttcgaa gggcgagggc 664261 gggccgcttg acgggacact tctctattcg ctctatttgt tccagcgtgc gtttaactat 664321 tttcaaatgg gctacgcatc ggcgatggcg tgggtcatgc ttgtcattgt cgggctgatt 664381 acgctcatat tgtttaaaac atcgtcatat tgggttcatt acgagtcaaa ggaggaatga 664441 cggatggagc cggtcaacca gcctgtcaga gaagccccgg tttttgagag aaaaaaagcc 664501 gggcgcgtca gtcccaaacg catactgttc catgttttta cggcaacgct ggcggtgttg 664561 ctgctgtacc cggttatttg gctgtttgtc agctcgttta aagaaagcgc cagtattttt 664621 acaacctcac attctctcat tccagaccct tttattctca gtaactatgc tgaagggtgg 664681 aagggcattg cgggacagcc gtttctgacg tttattaaaa actcggcgat tattgtcggg 664741 ctgtcaacaa tcggtgccgt catgtcatcg gctgtcattg cgtacggatt tgcgcgtata 664801 ccgtttaagg gaaaaaaatt ttggtttgcg tgcatgatgg ggacgttaat gctgcctcat 664861 gaagtgttga tgattccgca gtatattatg tttgcgaaat tagactggct gaattccttt 664921 aaaccaattg tcgttccgca atttttcggg catgcgtttt ttatctttct gatgatccag 664981 tttatccgga cgattcccga ggagctggat gaagccgcgc gaatcgacgg atgcggacgc 665041 tttgcctgct tttggcggat cattctcccg ctgattgccc ccgcgcttgc gacgtctgcg 665101 attttctcct tctattggaa gtgggaggag ctgattcagc cgctcttgta tttgaataag 665161 ccggagcttt accctgtttc acttgcgctg aagctttttc tcgatacaga gtcggcttcg 665221 aactggggcg cgatgtttgc catgtcagcc gtctcgttat tgcctgtgat tcttgttttc 665281 tttttgtttc agaaatatat cgttcagggc atcagtacga ccggattaaa ataaaaagga 665341 gtgttgcaga tggcacagct tatctttgat gaagaaaagg tgacgtcggt tattgaccgg 665401 atcgtgaaac ggacatttca gatggatttt gcgtgggatt ggccgggcgg cgttgcgttt 665461 tacggtgtgg cggaggccta tgaagcgacg gaaaacgagg aatatatcaa tctgttaaaa 665521 acgtgggtgg atgaacagct ggaggatggg ctgccgccgc tttcgatcaa cggagtttcc 665581 attgggcata cgcttttgtt cctccacaag gtgacaggtg atgacgtgta tttggaaaca 665641 gcggccgaga tggcggaata tgtgctgcat aaggcgccgc gctttggcga gggtatcctt 665701 cagcatacgg tgaatgcggc agaatacgta ttccctgaac aggcatgggc ggatacgctg 665761 atgatggctg ggctgtttat gctgagaatc gggcgggtca tggagcgtga ggattatttt 665821 gaagacggcc tgcgccagtt tcacggacat gaggatgtgc ttcaggaccc tgtcacgaat 665881 ttgtactacc acgcctggga caacaaagcg caaaatcatc tgtcggggat ttattggggc 665941 agggcgaacg gctgggcggc actcacgatg gcaaaggcgc tcccgcttat tgaggtgaca 666001 catccttcct ttatgatcat cgacggatcg ctcagagacc agctgagcgc gcttgtccgg 666061 cttcaggatg aatcagggct gtggcataca attttggatg atccggattc ttatctggag 666121 gtttcggcat cagcgggtat tgcttctgct ctgatgtcga gcggaaagct gtatacaaaa 666181 tatgtgcaga aatcgcttgc cgccattttg gatgcagtgg aagaggacgg acgggtcagc 666241 agggtatcgg ccgggacagc cgtcatgaaa aatgccgaag gatacaaaca ggtgccttac 666301 aaacgaatac aaggatgggg gcagggactt gcgctgacgt ttcttgctga tgttttgaaa 666361 acgaaaaaac gcttgtatca gtaaagatag cggcgggggg agagggatga aaaaacagcc 666421 tcaacagaag gaacgggttt ctcgctggaa gggaacgtat ttcaaaagaa actttgtctt 666481 cattttgctg attgcctgta ttcccggatt gctgactggc ggcgcaatct actttctttc 666541 gatcgacaag gtggagaaag agctgcagag atcgcatgaa acacaggtgg cgcgtgaggt 666601 cagccgaatg gatgagaagc tgggagtgct tgaactggca ctcacccaga tggcctacga 666661 ttcttcactg atgaacggat tggccgagag ggatttggag aaagacttta cgttctccta 666721 tcaattaacg aaaaagctgt ttcttttgcg ggatcagcag ccgctgatcg agcaggcttc 666781 catctttctg aacagccccc ggccacttgt gctgagccct gaatacagcg ctttgacaga 666841 acaggaggcg cttcgcaagt atcgctcgct gcttgcctca gaccacagca tttattggaa 666901 acggtcggga aaccaagcga tgctgatcca gctcattccg ggcgcggcgg agaaaccgtt 666961 cggcgcgatc atgctggcgg ttgatccgaa agaaatggaa tcaatcctgc aaagcttgtc 667021 cccctatcct gatggcagtg cgttgctttt agatcaaaat cgagaggtgc tgtttcatga 667081 gggggaaaaa gattttgaaa agactttact tcatgagata aaaaaacagc ctgctgagaa 667141 cggccatttt cagatggaat ggaaaggcaa ggtgtattct gtctcctttg gagaaatgaa 667201 ccggatgcat cagcaatgga cctttgtgtc agcggcgcct ctttcagcta ttacagcgcc 667261 gatggtgttt ttatcaaaag tgatcatcgt gatgctggtc atttgcatcg gtttggcggt 667321 gtgcatgaca tggtatgcat caaaaaaaat ctatcgtccc atccagcatt tgcttggctt 667381 gtttaccgga ggagagaaga aaacatggca ggcgtccggg caggatgaat tcaaatggat 667441 tgaaaagaga tggcaggatc tatcccttga aagccggaag ctccaacagc agctcctgcg 667501 gcagacgccc catatgaaaa agagtttttt gcagcatctc ttacagagcg atttttacta 667561 tgacaacgag gaaagcctca gatttcggat ggaggaggct ggctggaaca tcggcggaaa 667621 cgtgtttcat gtgcttgatc tacaggtgac agggctccgc tgtgaaaaaa gcatcttccg 667681 tgaaggtgat gaacagcttg ccgtgtttac actgactaat atcgctgagg aattggcggc 667741 taaacgcgtt tttcagctct ccatacttga tatcggccgg ctttctgtca ccgttcttgt 667801 gatgaaaaca aacagctctg atctgaaggc gtatataacg gagctggcac gccaatttgg 667861 agatgtaacc ggactatgcc tgacctcgac attgagcagc aagacggagc gtgtcacgga 667921 aattccttct ttatttcagg atgtgaaatg cggcaaatcc cgcaggaagt ttgctaaccg 667981 ggatcaggtc attgatttgc aggccgactt ccctcgggat gagcagttcg ctccttatta 668041 cccttttgag ctggaaaaac aaattgttca gaccatccgg ctggaaagaa aacaggaagc 668101 caaggaactg atagatggat gtatgaagga actgtcggaa aaagcggcca tagacaggca 668161 tgtgcattcc gccctgattc agctgttttc ccgcattcag gaggatattt tgcattccgg 668221 gctcaatccc agcgaactgt ttcagcaccg gaatccgttt cttgatattt cagaattgcg 668281 cgaacctaac gaagcggcgg cctggctgat ggatgtagtg gtgacgcctt acctttccaa 668341 gcttgagggc agaaaaaaca gacagcaaaa gcagctggca gaacgtgtga ttgcgatgat 668401 tcacgaacag tatatggcgg acatttcatt ggaaagctgt gccgatgcgc ttggcatgaa 668461 ttcctatacg ttaagcaagg catttaagca agtgaccggc attaatttta tcgattatgt 668521 gacccagatc agaatcgaaa aggcgaaaga actgctggtc aatacgaata aaaaaattca 668581 tgatgtgtct gaagaagtcg gctatcgcca caattatttc aatcggattt ttaaaaaaca 668641 ggtcggcatg ccgccgggtg tcttcaggca aatgtatcag gaaacgccgt gaaaggagag 668701 aacatgtgat gaagaaaccg attcaagtat ttttagcggg ggattccact gtgagtgact 668761 gcccgcctca tgaagcgccg atggcggggt gggggcaggt attcgggcaa ttgttttctg 668821 aaggtgtgct ggtccgcaat catgccaaag gaggagcgag caccaattct tttgtggagg 668881 aaggaaggct tcaagcaatt gccgagcaca tcacacaagg cgattatttg ttgattcaat 668941 tcggccacaa tgaccaaaaa ccgcggggga cgaagccgta ctccacattt cagcagtttc 669001 ttaccttgtt tgcagatacg gcacgcgaaa agggcgcgca tcctgtgttc gtcacatcgg 669061 tgcagcgccg ccgctttgat gaaaacggac ggatcgagca tacgctcggt gagtatcccg 669121 atgcgatgaa agcactggcg aaggagctcg atgtacctgt gattgatctg cttgcgaaaa 669181 caaaggtgct gtatgaagca tacgggccgg aggagtcgaa gcgattgttc gtttggtttc 669241 agccgaatga acatccgaat tacccggacg gcattgagga caatacgcat ttttcggaaa 669301 aaggtgcaat ggaggttgcg aagcttgtgg cagaaggcat tgaagagctc ggacttccgc 669361 ttaaggacca ccttgtgagc cgggagggaa aagaacatgt ataaggaagg cgcttgcttg 669421 taccgcaatc cgctccggtc taaaagcgat gtgaaggatt ggcggatgga gggaggcgga 669481 cagatctcat ttgacgatca cagcttgcac ctgtcacatg tccaggatga agcgcacttt 669541 gtcttttggt gtccggaaac ctttccagac ggcatcattg tgacatggga cttctctccg 669601 atcgagcagc ctggactgtg tatgctgttt tttgccgctg cgggtattcg cggcgaggat 669661 ttgtttgacc caagtctcag gaaaagaaca ggaacatacc ctgagtatca ttcaggagat 669721 atcaatgccc tccacctgtc gtatttccgc agaaaatacg cggaggaaag agcgttccgc 669781 acctgcaatt taagaaaaag ccgcggtttc catctcgccg caatgggggc cgatccgctg 669841 ccttctccag acgacgctga ttctccgtat cgtatgaagc tgatcaaaga caaaggctat 669901 gtgcactttt caatcaatgg tctgcccatt cttgagtgga tggacgacgg cagcacatat 669961 gggcctgtgt taacaaaagg aaaaatcggg ttccggcaga tggcccccat gaaagccgtt 670021 tacagggatt ttgccgtgca tcaagcggtg agaagatgaa gacgactgta acggatgcgc 670081 tttatgcagg ctgcgaagcg gtggtgaaaa tagcatggct caacgggctg tggctgttgt 670141 ttacactttt gggcggcgtt cttttcggat gggcgccgag cacagctgcg atgtgtgccg 670201 ttataaggaa atggctgatg gggcaaaagg atgtcccgat attttcgtta tttctcgata 670261 cctataaaaa agagtttctc aaggttaatg cgatcggatt ggcgttttcg gctcttttgc 670321 tcatattgtc tgccaactat cattattttt ctgccagtac gaattggctg tcctttgccg 670381 taacaagctg cacgctgctt gcagggcttt tgtatatcat cgcgctgatg tatgtgtttc 670441 ccctttatgt gcattaccag ctcccgcttc gcaaatatat tccgcaggca ctgctgtttg 670501 gcgccatgag accgctgaca actggctgta tgctgatcgg gtgcggattt gtcctttatt 670561 tgctgtatac gcttcctggc ctgatcccat tttacggccc gtgtttattt gggcttgtgt 670621 tgatgttttt tgctcttagg ggatttcaaa agacggaggc ccagcaccat caagccgggt 670681 aacaaaaaaa tgacaaataa gcaaaaaagt gcagtgtccg aaataggcag atgcaaaaaa 670741 gtgaaattga agacagctca caaagcgcat aaaatccaat ttaagtaagc gcttacagat 670801 aaatgagaag gagctgtctg atgattagac gaaggaaacg catgtttacc gctgttacgt 670861 tgctggtctt gttggtgatg ggaacctctg tatgtcctgt gaaagctgaa ggggcagcgc 670921 ggcagatgga agcgctgaac cgggggcttg tagcggtcaa gacggacggg ggcatttttg 670981 tcagctggcg gtttcttgga accgaaaacg catctgtttt gttcaatgtg tacagagacg 671041 ggcaaaaact gaatgctgcg cctgtcaaaa caacgaacta tgtggataaa aacggttcgg 671101 cgggctcaac gtatacggtt cgggctgttg taaacggtac cgaacagccg gcttctgaaa 671161 aagcctccgt atgggcgcag ccgtatcatt ccgtcccgct ggataaaccg gctggcggca 671221 cgacgccaaa gggtgaatct tacacgtaca gcgctaatga cgcaagtgtt ggcgatgtgg 671281 atggtgacgg gcaatacgag ctgatcctga aatgggaccc gtccaactca aaagacaatt 671341 cacaggatgg ctatacgggt gacgtgctga ttgacgcgta taaactggac ggcacaaagt 671401 tatggcggat caatctcggc aaaaacatca gagcgggcgc gcactacacc cagtttatgg 671461 tgtatgacct tgatggtgac ggaaaagcag aagtggcaat gaaaacggca gacgggacaa 671521 aagacggcac gggcaaagta attggaaatg ccaatgcaga ttacagaaat gaacaggggc 671581 gtgtgctttc aggccctgaa tatctcactg tgtttcaagg ttcaaccggg aaagagcttg 671641 tcaccgcaaa ttttgaaccg gcgcgcggca atgtgtcgga ttggggagac agctacggca 671701 accgtgttga ccgttttctc gccggcattg cctaccttga tggacagcgg ccgagcctga 671761 tcatgaccag agggtattac gctaaaacca tgctagttgc ctataacttc agggacggaa 671821 agctgtcaaa gctttggacg ctggactcct caaagtcagg aaatgaagcg tttgccggac 671881 aggggaatca caacctgagc atcgcggacg ttgacgggga tggaaaagat gagattattt 671941 tcggctcaat ggctgttgat catgacggga aaggcatgta ctcgaccggc ttaggccatg 672001 gggatgccct ccatacagga gatcttgatc cgggccggcc ggggcttgag gtgtttcaag 672061 ttcatgagga caaaaatgca aaatacggct tatctttccg ggatgctgca actggaaaaa 672121 tcctttgggg cgtttatgcc ggcaaggatg taggccgggg aatggctgct gatattgacc 672181 cgcgttatcc gggacaggag gtgtgggcaa acggttctct ctactcagcg aaaggggtca 672241 aaatcggaag cggggttccg tcctcgacca acttcggcat ctggtgggac ggcgatctgc 672301 tccgggaaca gctggacagc aaccgaattg ataagtggga ttatcaaaac ggcgtatcga 672361 aaaatatgct gactgcatca ggcgcagcgg ctaacaacgg cacaaaagca acaccaacgc 672421 ttcaggctga tctgctcggt gactggcgcg aggaagtggt gtggagaacg gaggacagca 672481 gtgctctgcg catttacacg acgaccattc cgactgagca caggctgtat acgctgatgc 672541 acgatccggt gtaccggctt ggcatcgcct ggcaaaatat cgcctataac cagccgccgc 672601 acacaagctt ctttttagga gacggcatgg cggaacagcc aaaaccaaat atgtatacgc 672661 cttaactgaa agggggaagg aacgggctgc gcgcagcccg ttcccatcaa atgaaaccaa 672721 aaaagaggca aatggaatac ctgaccagag gtttgattgc ggtacagaca gaacagggcg 672781 tgtttgtcag ctggcgtttt ctcggcacgg atcatgagac gacggctttt cacctttatc 672841 gggatggaaa gcggatcacc cgcgatccaa tcgctgaaag cactaatttt ctcgatcaaa 672901 acggaacggc tgactctgtt tatcaagtgg cggctgtcaa taaaggacgg gaagaaaagc 672961 tttccaagaa agctcgtgtt tggcaggaaa atgtcctgga ggttcctctt gccaaaccgg 673021 aaggcggtgt gacgccggac ggaaagccgt acacttacag cgccaatgat gccagtgtcg 673081 gggatataga cggggatgga gaatatgaaa tgatcctgaa gtgggacccg tccaattcaa 673141 aagacaacgc tcatgacggt tataccgggg aggtgctcat agatgcctat aaactggacg 673201 gcaccttttt gtggcgcatc aacctcggca gaaacatcag agcgggtgct cattacacgc 673261 aatttatggt gtatgacctt gacggtgacg gaaaagcaga aatcgccatg aaaacagctg 673321 acggcacaac agacgggaaa ggacatatca tcggtgatga gcaggccgat tttagaaacg 673381 aacagggcag aattttgtcc ggtccggaat atttgaccgt gtttaaagga gaaaccggtg 673441 aggcgctcac gaccgtggaa tatgaaccgc cccgcggcaa gctggaggat tggggagacg 673501 gctatggaaa ccggatggac cgttttctcg ccgggaccgc ttatttggat ggggagcggc 673561 cgagccttgt tatggcgcgc ggctactata cgagaaccgt gctcgtggca tacgatttca 673621 gaaacggaag gctcaaaaaa cgatgggtat ttgactccaa ccagccggga catgaagcat 673681 acgcaggaca ggggaaccac agcttgagcg tggcggacgt cgacggagac ggaaaggatg 673741 aaatcatata cggcgcaatg gctgtcgatc atgacggaac cggcctgtac tcaacgggcc 673801 tcgggcacgg agacgcgatg catgtagggg atctggaccc gtcacgaaaa gggcttgaag 673861 tgttccaggt gcatgaggac gccacgaagc cgtacggact gtcgctgcga gatgccggaa 673921 ccggtgagat attatggggc gtccatgctg gaactgacgt tggccggggc atggcggctc 673981 atattgatcc aagctacaaa ggatcgctcg tctggggaat tgatccgccg ggcaatgatg 674041 gcatgtcgta cgggcttttc acgagcaaag gcgaaaaaat cagcgacaaa gcgccctctt 674101 cagccaattt cgccatctgg tgggacggtg atttggtcag agaactgctt gatcatgact 674161 gggacggaac gatcggcagg ccaaagattg aaaaatggga tgctgaaaac ggctgtctga 674221 agacgatatt tcagccggcc ggcgtgttgt ccaacaacgg cacgaaagga aacccggttc 674281 ttcaggccaa cctgttcgga gactggcggg aagaagtgat atggagaacg gaagacagca 674341 gcgcgctccg tatctataca acaacacatc tcacccgcca ctgcttttac acgctgatgc 674401 atgatccggt ttacaggctc ggcatcgcct ggcagaatac cgcctacaac cagccgccgc 674461 acacgagctt ttacctcgga acgggaatga aaaaaccgcc gaagcccgcc ctgtacatag 674521 cgggaagcaa agcggaggcg ccgctgtagg aggactaagg gataagacgc aaaggctgaa 674581 cgctacgcca agatgattag agaactggca ggacgaacca atgctcaagc gctgtacgca 674641 ccggtttttt caagggaaga gctatccgtg atggaagctg tataaaaaac gaggaggaat 674701 gaaaaaatgg caaatcatat ttatcttgcc ggcgattcga ctgttcaaac gtatggagac 674761 agcacaaatc aagggggctg ggggcagttt ctcggctcgc atctgccgga gcatattcaa 674821 gtgatcaaca gagcgatcgg gggaagaagc tcgaaaacat ttgtggaaga gggcaggctt 674881 caggcaatcc tcgatgtgat tgagccggat gattggctgt tcgtgcagat gggccataat 674941 gacgcgtcaa aaaataagcc ggagcgctac accgagccct atactactta taaacaatat 675001 ttaaagcagt atatcgcagg cgcgcgggaa aaaggcgccc atccgcttct cattaccccc 675061 gtagcccgct ttcattacga aaacggcgtg tttttgaacg attttcctga ttactgcatt 675121 gccatgaagc agacggccgc tgaggagaat gtccagctca ttgatctgat ggagaaaagt 675181 ctcgctttct ttactgagaa gggcgaggaa aaagtgtaca cctattttat gatttcagaa 675241 gggattaacg attacacgca ttttacaaaa aaaggcgcaa atgaaatggc gaaacttgtg 675301 gcaaaaggca taaaggagct cggcctgcca ttgacagaat cgatcatcaa agaaaggtga 675361 aaatgtgatg agaaaactgt atcatggcgc ttgctattat ccggaattat gggatgaaga 675421 gacgattcag caggacattg acatcatgcg tgaagttggc gtaaatgttg tgcggatcgg 675481 cgaatttgcc tggtcagtca tggaacctga agaaggaaaa attgacgtcg gttttttcaa 675541 agaaatcatc gcccggctgt atgatagcgg gatcgaaacg attatgtgca cgccgacgcc 675601 taccccgccg atttggttct cacatggccg gcccgaacgc atgcatgcca atgaaaaaag 675661 agagatcatg gggcatggct cccgtcagca tgcctgtacg aacaacccgt atttccgaaa 675721 aaaagccgcc atcatcacca cagccatcgc caaggagctt ggccggctcc cggggctgat 675781 cggatggcag ctagacaatg agtttaaatg ccatgttgca gaatgcatgt gtgagacatg 675841 cttgcgccta tggcatgact ggctcaaaaa tcgctacggg gtaattgagc gcttgaatga 675901 agcttgggga accgatgtgt ggagcgagac ctatcagacg tttgagcaag tcccgcagcc 675961 gggaccggcc ccgtttctgc atcatgcctc tctacgcact atgtatcagc tgttttcgat 676021 ggagatgatc gcttcgtttg cggatgaaca ggccaaaatc atccgctgct attcagatgc 676081 gccgatcacg cataacggat cagtcatgtt cagcgtggac aatgagcgaa tgtttcagaa 676141 tctcgatttt gcctcctatg acacgtacgc ttcgcaggaa aacgcctctg cctttttatt 676201 gaactgtgat ttatggagaa atctgaaaca agggcgcccg ttttggattt tggaaacgag 676261 tccgtcgtat gccgcctcgc ttgaaagctc cgcttacccg cacgcagacg ggtatttgca 676321 ggccgaagcc gtatcgtcct acgccttagg gagccagggg ttttgctact ggctatggcg 676381 acagcagcgt tcaggcagcg agatttccca cggttcggtt ctcagtgcct ggggcgaacc 676441 caccatcggc tatcaaaatg tgctggcggt tgagcgggca agaaaggaaa tcgagcctat 676501 tattctatcg actgaacccg ttcaagccga ggcggcgatg acttactctg acagagcaaa 676561 agcatttatt aaaactgagc ctcaccgggg actccggcat cgttcgcttg tgacgcattt 676621 ttatgaacgt attctcaaca cggggattca ccgtgacctt attccggaag gcgctccact 676681 ggacggctat cgcttgctgt ttacgccatt tgtgccgtat ttgtcttctg aatttatcaa 676741 aaaagcttcg gcattcgctg aagcgggcgg catctggatc accgggccgc tgacaggagg 676801 acgcacatgc gagcatacca ttcataccga ttgcggactt ggcgaacttg agaaaacgtc 676861 agggatcaaa acacttttta cctttccgat gaatgagaac gtgaatacag gaaaagcgtt 676921 tggcatcacg gcgccgctcg gactgtggag cgcggtgttt gacacagaga gcggaaacac 676981 ccttggcacg gttgaagcag gaccgggggc gggccatgct tttctgacgg aacggaatta 677041 cggcgagggg aaaattgtca tgctgggctc gcttccatcc gggaaagaag gggatgcgat 677101 gctggaagcg ctcgtcaggc attatgcgga ggaagctgtt atttccagcc ggtcggatgt 677161 gacacccggc acgatcgttg ccccgcgtat aggcgaaaac ggccttgtgt ggatcgttgt 677221 gaatatggat ggaaaaggcg ggagcgtgac attgccggaa tcgggaacgg atttgttgac 677281 gcaccgcttg gaaaaggcgg ggagactggc ggtcggaccg catgaatacc gtgtgattca 677341 atttgacaat cacagctgat tctttgtatc gaatcagctt ttttctatgg agggagagac 677401 agatgaaaaa gatcaaatgg ttatcaggac agccaaaggt gacaagcggc gtgacgtggg 677461 gcatgccatg gaaaaaagga gaattaaaaa aaggagaccg tctggcgctt atgaatgaaa 677521 acgcggaaac gcgatatgtg caaagcgaac cgtcggccta ttggccggac gggagcatca 677581 agtggacgaa gcacgcggcg gtgtttggcg gtcaggaaaa ccaaagcttt acagtgcaca 677641 aaagagaagt gccgcagcca actgaatcgc tcagcattct tgagacagag catgatatcc 677701 aagtggatac aggagcactc gtttgtacca ttcataaaac aggatctgat ttcattcaat 677761 cattgcagat caatggaaag ccgatcgccg caggcgggag gctcgttgcg ataagagaaa 677821 cgagaaaaga gtcagcggcg aaaatggttc ttttgcatga aaggtctgtc agctttatca 677881 aacgggcggc gattgagcag agtggtcctg tcaaagcagt agtcaaaatc gagggagtgc 677941 atgtgcttca taaaacgtat gaggaatggc tgccgtttgt catccgatta acgttttatg 678001 ccgggctgtc tgagatcggc cttgtgcaca cgcagctgat tgacaggagc ggtaaactag 678061 aattcgttaa ggggctcggc atcgaattcg accttttttt ggagggagag ccgtacaacc 678121 gccatttccg ctttgcggga gagaaaggga tgtataaaga acccgcccag ctgtttggca 678181 cacgtaaatt caatgaacga tatccgcttt atgaaaaaca aatcaatggc gaaatgctgt 678241 ctccagatga agagcataag gaatggtttg cacatggcac acagaatgcg gtttgggacg 678301 atgtcaagat cgtgcaagat tccagcgatc attacagcct gtcaaaacgg accggaaaag 678361 attatgcgtg ggttggaatg ctgcatggca gccgggcgaa ggggctctgc tatgcgggcg 678421 gaaaaaatgg cggtgtggct ctcggcctgc ggtatttctt tgagaaatat ccttcagcac 678481 tggaaatcac aggtcttgcc ggcagccgcc ccaaaatgac tatctggctt tggcctccgg 678541 acggcgaagc gatggatttg cggcattata caggaaacac tcacgtggcc agcgcgtatg 678601 aaggctttga tgaaatgcgc tctgatccga caggcattgc gaacacaaat gaaataagcc 678661 tggcgtgctt ttcgcacatg ccgtctgacg aagtcctcaa tgcgctggct gacaaatggc 678721 aggcgccccc gctcattgta tgcgagccgg acgtctatta cgaatcaaaa gcactcgggg 678781 tatggagcat cattgacaca tcccatccgc tcaaaaaaga gctggaagaa cagcttgatg 678841 cggcctttct gttttataaa aaggaagtag agcaacgcag atggtacggt ttttggcatt 678901 atggcgatgt catgcatacg tatgacccga tccggcatat gtggcggtac gatctcggcg 678961 gatacgcatg gcaaaacaat gagctcgttc cgaccctatg gctgtggcag gcgtttttcc 679021 gctcaggcag agaggatatc ttccgaatgg cagaagccat gacccgccat acgagtgaaa 679081 cggacagctt tcacctcggt gaatatgccg ggcttggctc acggcataat gttgtgcact 679141 ggggatgcgg ctgcaaggaa gcgagaatca gcatggccgg gcttcataaa ttctattatt 679201 atctgacggg tgatgaccgg acgggagatc ttttgacaga agtgaaggat gccgattatg 679261 cccttgtcaa aaccgatccg atgcgcgctt tttacgagaa aggcaagcac ccgactcacg 679321 ccagaacggg accggactgg gcggcgtttt gctcgaactg gctggcggaa tgggagcgga 679381 ccgaaaattc ggaatatctc aaaaaaatcg aaacgggaat caactgtctg aagcggctgc 679441 cgctccgctt attatctggc ccgacatttg aatatgatcc ggcgacctcg atgcttcatc 679501 atatgggaga cggcattgcg ggcggatatc atatgatcat tgccttcggc gcgccgcaag 679561 tgtggatgga gctggctgag cttcttgatg actgggaatg ggaggatatg ctgagtgaat 679621 tcggcgaatt ttacacactc agtgatgagg aaaaacgaaa aaaaagcgga ggcgctcttc 679681 atgacgggca ttttcactgg ccgatgttcg ccgccggtat gacagcctac gccgcaagaa 679741 aaaagcaaga tcctcatctc gccgccaaag cgtggaatct tttgctagaa gataagctca 679801 gccatacgcc gcttccgatc aaaccggagc gcatcgagac atggacgcag ctagaggagc 679861 ttccatgggt gacaacgaac actgtctctc aatggtgttt aaatgtcata gcggcgctgg 679921 aactgatcgg agattccctt ccggcaaaaa aagaaacatc gggcaaaaaa ggataacagc 679981 cggaatttca taggagaaat ggtgcaaaaa atgaagattg caagaattta tgtaagcgct 680041 ttatattgag aggggcaaag gggaaatgca aattgaaaaa agggggactt acgcaacatg 680101 aaaataagaa tgcgaaaaaa atggatggcc ttgccgcttg ctgccatgat gatcgccgga 680161 tgcagccatt cggaaacatc caattcagca agcggttcga aagatacgat caaaattatg 680221 gcgccgctct tatcgccgga aagcccaagt gataagagcc cttcattaaa agcgctcgaa 680281 aaatacacag gcaaagagat taaggtcaca tgggtgcctg attcatccta caacgacaaa 680341 ttcaacatcg tcatggcttc aggagagatg cctcacgcga ttgtcattaa agataagtca 680401 gccggcttta tcaaatctgt caaagcaggg gcgttttggg agctgtctcc ttatttaaaa 680461 gactacaaga atttaagcca ggcagatgaa aagattttga agaacagctc ggtgaacggc 680521 gaggtgtacg gaatctacag aacgagggat ctgatcaggg cgtgtatgat catcagaacc 680581 gactggctga aaaatgtcgg tctggatatg ccggaaacgc ttgatgattt ctatgaagtg 680641 ctgaaagcct ttaaggaaaa agatcctgac ggaaacggca aggatgatac gtacggcatg 680701 gtcgtgccga aatggatggg actcggcaac ggaagcccat gggatgttct gcaaatctgg 680761 ttcggcgctc cgaaccgcta cggtgttgaa aacggaaagc tgattccaga ttttacaacg 680821 aaggaataca tggatgcgct cacgtttttt aaaaagctct atgatgaggg cttgatcaat 680881 aaggactttg ctgtcatgga ttctgcgaag tggaatgatc cggttgtaaa aggaaaagcg 680941 ggtgtcatcg ttgatacagg ctcaagagcg tctcaaatcc aaagcgcgat ggaggaggcg 681001 gatgagtcga acaaggatat cattgatatc gtcggctcgc ttgagggacc gaatggcaag 681061 cgcaccttcc cgacatctgg ttattcaggc atgatcacga taccaaaatc aagcgtcaaa 681121 accgaaaaag agctgaaaga ggtgctgtcc ttcctcgata agatgaatga taaggaagcg 681181 cagattctca cgaacaacgg agtgaagggc cgcaattacg agctcaagga cggcgtattc 681241 acctcacttg aaaaaaacaa taaatctctc ctgtatgagc atgaaggctt ggcacagttc 681301 agcatgtcga ttccgaaaag cgagtattac atcgaagacc agaaaaccaa gctcttccag 681361 catcgcaagg acatcataac cgaaggagaa aaaatagccg tctttaaccc tgctgagtcg 681421 cttgtatctg atgtctatac ccaaaaagga gcccagcttg acaacatcat cctcgacgcg 681481 agaacacaat ttatcattgg agaaattgat gaaaaagggt tcgatgatgc ggtggagctt 681541 tggaaaaaaa gcggcggcaa tgaactgatg aaggacttga acaaattgta ccaatcgtca 681601 aaataaaccg atgcgcctgc ctttcggcgg gcgccccggt atcacgaaag gagaacagat 681661 atggaaacag tgccgaagaa gagagatgca cctgttctca ccgctggaaa aggcatcagc 681721 tggatggctg cgctcaaacg ggacaaatgg ctttatcttc ttcttattcc cggtctgctt 681781 tatttcttga ttttcaaata cttgccgatg tggggtgtgc tgatcgcttt taaagactat 681841 tcgccatatc tcggcttctg gaaaagcgaa tgggtcggct ttgattattt caaagacttt 681901 tttatgaatc cggatttttt ccggctgctg cgcaacaccc tcatgctggc gagtctggat 681961 cttttgtttg cctttcccgc gcctctcatt ttggctctgc ttttgaatga ggtaagaaag 682021 gccgtgtata aaagatgtat ccaaaccttt atttacgtac cccattttgt atcatggaca 682081 attgtggtca gcatcacctt cgttttcttt actgtcgata caggtgtgat caacaaattg 682141 attatgagcc tgacaggtga gcagatttct ttcttgtcgg atgcagactg gttccggcca 682201 atgattgtga tgcaaagcat ttggaaggag acaggctggg gaacgattct atttttggca 682261 gcgcttgcta cggttgatca agagcagtat gaagcggcca tcatggacgg agcggggcgg 682321 ttcaggagaa tgtggcatat tacgctgccg gcgattagaa gcaccattat cgttttgttg 682381 attttaagaa tcggcagctt tttgaatctt ggctttgaac aggtgtattt gatgacgaac 682441 tcactcaacc gcagtgtggc tgacatcttc gacacgtatg tgtacatgat ggggattacc 682501 caaggggcgt atagctacag cacggcggtc ggtttgttta aatcagttgt cgggattatc 682561 ttgatttttg gcgccaatta cattgcgaaa aagtttgatc aggaaggatt gttttagagg 682621 agggagaggt atggctgaaa ttcacacgat gcacaacacc aaagccggac gggtgtttga 682681 cgtctgcaac attctgtttc tcggcggtgt cggcgcgatt accattttgc cgtttttata 682741 tattatcgcc ggttcctttg cgacagaagc ggaactcgcc cagcggagct tctttatttt 682801 cccgaaaacc tttacacttg atgcttacaa gtatgtgttt tcgacaccga cgttccttcg 682861 aagcatgggc gtgtccatct tcatcacggt ggttgggacg gctgtacagc tgttttttac 682921 cttcacgatg gcgtatccgc tggcgaaacg gcatgtgaag ggacggaatc tgctgttgaa 682981 tctggtgatt ttctccatgc tgttttcagg cggcatgatt ccgacgtacc ttgtcgtaaa 683041 atcacttggc cttttggata cgtattgggc attgattctg ccgatggcga ttaatccgtt 683101 caaccttatt attatcaaaa acttctttca gcagctgccg cgcgagctgg aggaatcagc 683161 aaaaattgac ggctgttccg aaatcggcgt cttctggcgg atcgccctgc ctctgtcaaa 683221 gccagttatt gcgacctttg cgctgtttta tgcggtcggg atttggaatg atttcttcca 683281 cgctctctta tatatcaatg acagtgcaaa atggccgctg caaatggtgc ttcgccaagt 683341 cacaatttta tcggatttaa cggcgaccaa tggtgatacg atgcaaaatg cagttccgcc 683401 ggagcaggga attaaactcg ctgtcattgt cattgcgacg ctgccgattt tggcggtcta 683461 tccattttta caaaaacact ttgcaaaagg aatgctgatc ggttcggtga aaggctgaga 683521 aagggagtgt ttcatatcag tacattagat cagattaaga ttgcctatat cggcgggggg 683581 tcccaaggct gggccagaag cctgatgagt gatttgtcga ttgatgaacg gatgtcaggc 683641 acggtggcgc tctatgatct tgattttgaa gccgctcaga aaaatgaagt gatcggcaat 683701 cacagcggga acggcagatg gagatatgag gctgtttcta ctttgaaaaa ggcgttatca 683761 gccgcggata tcgtcattat ttccattttg ccgggatcac tggatgatat ggaagtcgat 683821 gtgcacttgc ctgagcgctg cggtatttat cagtctgtag gtgatactgt cgggcctgga 683881 gggatcatca ggggcttgcg tgctgtgccg atatttgcgg aaattgcccg ggcaataaga 683941 gactacgcac ctgaatcatg ggtcattaat tatacaaacc cgatgtctgt ctgtacaaga 684001 gtgctgtata aagtgtttcc cggcatcaaa gcgattggct gctgccacga ggtattcggg 684061 acgcaaaagc tattggcgga aatggtcacg gaaaggctgg ggattgaggt gccgcggcgt 684121 gaggatatcc gcgttaatgt gctcggcatt aaccatttta catggatcac aaaagcctct 684181 taccgccata ttgacctgtt gcctatattc cgtgaattca gcgcgcacta tggggaatca 684241 ggatatgagc tggaggggga atgctggagg gacagcgtct tttgttcggc acaccgtgtt 684301 gcgtttgatt tatttgaaac gtatggcgcc atccctgctg cgggtgacag gcatctggca 684361 gagtttcttc ccggcccata cctcaaacag cctgaagtat ggaaatttca tctcacacct 684421 atatcattca gaaaacaaga cagagctgag aaacgacaag aaacagaacg gttgatcgtg 684481 caacaacggg gcgttgctga gaaagcttcg ggagaagaag gcgtgaacat catagcggct 684541 cttctcggat tgggtgaact cgtcacaaat gtaaatatgc cgaatcaagg ccaggtctta 684601 aaccttccta tacaagccat tgtcgaaaca aacgcattca tcacaaggaa ccgtgtccag 684661 ccgattttgt ccggagcgct tccgaaaggt gtggaaatgc tggcggctag gcatatatcc 684721 aatcaggagg cagtggcgga cgcaggttta acaaaggata ctggcctcgc gtttcaagcc 684781 ttcctcaatg acccgcttgt ccagattgac cgcagtgatg cagagcagct tttcaatgac 684841 atgctccaat gcatcatgca aagctgagct tgccgattag ctctttccgg tttagaaagg 684901 aaagcattga ccatactgat agtataatca agaagtaggt gctatcaata tgggaaatta 684961 tttaagtgtt gcggtagaac tggtctgcgg tttaggcatt ttatttatca tcttaaagct 685021 tctcgggaaa acccaatttt ctcaaattac gccgtttgac tttatttctg ctttaatttt 685081 aggtgaattg gtcggaaatg ccgtctacga tcatgaaatc aaaatcaaag aaattatttt 685141 tgcttcgcta ttgtggggcg tgctgattta tattattgaa tttatcacgc aaaaaatgaa 685201 atcatcgcga aagttcttgg agggcgagcc gaatatcgtc atccgcaaag gggagcttca 685261 atataaagta atgaagaaaa ataagataga cattaaccag ctgcaaagcc tattgaggca 685321 agctgggagc ttttcgatcc aagaagtaga atatgcgatt cttgaaacaa acgggatggt 685381 cagcgtgctt ccaaaatcag actttgacaa accgacaaat aaggatttgc agattccttc 685441 gaagtccgtt tctctgccga tcacgttaat catagatgga gagattgtgc gggataattt 685501 gaaggaagca ggtgtggatg aacagtggct gaaacaagaa ttgaaaaaga agaacattga 685561 taagacagag gacgtgttat ttgcagaatg gcataaaaat aagccgctgt atactgtaac 685621 gtacgaacaa agcagatcaa catgactctt agaaaaaagc ttgcagcaag gcgcaagctt 685681 tttattgatt gtatgtccct tgtttgacag cacgtacatg gtacatgctc acttcagtgc 685741 tgatcagata gtcaggcttt ggtttgcctt tgtttgcttt atggccggcg atatgcgcat 685801 cgcttttttc ccattgcttc cagtgatcct ctgattccca gcgaatcatg acaacaactt 685861 cttcatcacc gcggcgcaca tttttctcaa gcactgtcac atcaattaaa ccttcttgtt 685921 tttcaatgat tccttcagcg ctgaaacgtt ctatgacttt atctgcaaag ccttctttaa 685981 ccgtcatttt tctcaactgt acaaacattt gtctcactcc aatcattctc acatatgaat 686041 aattgtaaat gaaattcatt ctcaatgtca aagaaagcgc agggcggaat cgaaccgccg 686101 tgcgcaacag tttattcttt taataaaaac acatttccgt cttcgtcctt aaattgaacg 686161 aaggtgcccc actccatttg attgggctca ccgagaaatt ctacaccgtt tgtcttcatt 686221 ttctcgtatg taccaaagat gtcttcgcat tcaaacacaa tagaagcctt catttgctct 686281 gagcctttca tcatggcttt cgggtaaatg actaaacgag tctcggctcc ttttggcgca 686341 acctccagcc agcttgcttc aggtcccatt gggtgatccg ctgcaatatc aaagcctacc 686401 ttctctgtcc aaaattgctt cgctttctgc tggtcctcga catatacagc aacagtgcca 686461 atttgtttga tcatagggaa acctccaagt tgaaaagata ataatactat aacctgttta 686521 cggccgaagt aacataaaaa aatcagccgg gaaaccggct gattattaaa atgagcagct 686581 tacaacatcg atgtgatttg tgtctaaggc gaaataaacc cagcggcgcc gtgaggaatc 686641 ccaataaaag ccgccgacgg atcttctgcc aaggatgatc gggtaaaacc aaaatgagcg 686701 gccattggtt aaccagacat aggtaaatcg gaaaaggcaa ggacgaatgg tgattggttc 686761 aactaacaaa acggctcctt gagaaccctg cggttttggg ggtttcgctg gtatttggga 686821 aggaggaggt ccctgcggcg caccgccgaa gcctgggctg gcaccgctgc caataccagg 686881 gccggagccg ccgccaaagc ctggaacagc accaccgcca atgccaggac cggagccgcc 686941 gccagagccc ggaacagcgc cgctgccaat gccaggccat ggatatcggt attcatattc 687001 aaaagcaggc caaggctcat aaaaatgccc cgcaaacata taaggatcaa cataatacat 687061 gtgataacgt cctttctcat tgtaaactgt acattgcagt ttatgcgggc ggactcttat 687121 tggtgcattc gcctaaggat atgaagctgg aatgctctca gagagcagaa tcatttgatt 687181 tttctctagt cttattcaca attccgattt atcattttat aatgaaagtg cttctattac 687241 gaaaaaggag acagaccgtg aatatcgatc aattattata tcaatatatc atagacaaca 687301 ctgcggatat tactgagaaa tggttcagtt tgcgttgcca gctaaaaggc gagctatatt 687361 ccgccagcca tttaagtgaa gaaacgaaaa cacttttaac cgagcagcat acatttacca 687421 atataacaat cgcaagcgca tttctggagg atcaaaccga ttttcaagaa aacatgacaa 687481 aatgggcgca aaacgttgcg aaaaacaggg tagagcagga tgttcaagtg catgaggtcg 687541 tagaagccat atccaattca agaatctcat tctgggacgc agtcgccaca tttataaaag 687601 agaatcagga gattgtgaca aatgaggatg cagaccgatg gaaccgcatt gtgaatcagt 687661 cgttcgataa gctgattatt gaattctccg agcagtacca aaaattcatg ctgatgaggc 687721 ttacatctca gcaggaactg atctcagagc ttggctgccc ggtcatttcc attgccgatg 687781 gaatcgggat attgccgctt atcggctcca ttgatacaaa acggcacagg tcattttaga 687841 aacagtgccg gtccgctgtg tcgagagaaa aatcacaagc ctcgtcgttg atctttcggg 687901 tgttccgatt gtggatacca tggtggctca gcaattgtac aacctgtcta aaacactttt 687961 cttattaggc gtcaaagccg tattttcagg aattcgcccg gatgtggccc aaacatcgat 688021 tcaattgggg cttgatttta gtgaatatga aacgtacggc acgctgaagc aggcattaga 688081 aaacatgggt gtccgctgta ttgttgagga attggaagaa aacaaatagg aagtttccag 688141 gcatatgatt gtccgtcacc gggtgatcat atgccttttt gatttgaaca gaaatcacca 688201 ttgatttatc gaaaaaaaca taatattata attcttataa gaatactgtg aattaaaacc 688261 tattcaacag gggggaaggt cttttggttt ctaaatcaac gattgatccg gaagtgattg 688321 aaaaaatcat cagctcgctg gaaacactcg atttcggcac ggttcagatt acggttcatg 688381 attctcagat tacccaaatt gagaaaatag aaaagcaccg tttttcgctg aaaaggaaag 688441 aatcaaaatg ataatgtaaa gggcgtttgt tttcattaaa ttctccttaa aacatataca 688501 tatttcatcc aatttttata taatagacct ttaagatcat tttttaggag gatttttgac 688561 atgcaagcta cggttcacga gagtaagcaa tcgatcatgc aacgcatttt gacagtcttt 688621 gtcttcacat tgctgatcgc gactgtcggc ctttttatcg gccaatttgt tcctgtcgct 688681 ttgatgctgc cgctttctat tcttgaagtg gcgatgatta ttctggcctt ctggatgcgc 688741 agaagaaaag cggtcgggta tgcgtttgta tatacattcg cgttcgtttc cggcattacc 688801 ttatttccga tcgtcagcca ttacgcttcc atcgccggcg cctatgtcgt gctcgaagcc 688861 tttggctcta catttgtcat ttttgccgtc ttgggcacaa tcggcgcaaa aatgaagaag 688921 gatttatcct tcctgtggtc gtttctgctg gttgcggtgc tcgcactcgc agtggtaggg 688981 attttcaaca ttttcagccc gttaaactca gcggcgatga tggcgtattc cgtgatcgga 689041 accatcgtct tttcccttta cattttgtat gatttgaacc aaatcaagca ccgccacatt 689101 acggaagact tgattccggt tatggcgtta tcgctgtacc tagactttat caacttgttc 689161 atcaacctgc tccgcttctt cggcattttg agcagtgatg attaatgaaa aagcgtctgt 689221 cattggatag gcgctttttg ccatacatca aaaaggcagg tggagtattg gtgaaaaaac 689281 aaatgggcgc atatgtatct ctggcagcag ctatggcgat cgtcggcagt tctgtcgttg 689341 tcggcaagct gatggtcgaa cggattccgg tctttctttc ctcaggattg cgttttttga 689401 tcgcttctgt cgtattgctc atgctgctgt tttgcattga aaaagggttt ccggctttga 689461 cgaaaaaaga tgtgttcgta ttactggtgc aatcattcac aggcgtgttt ttgttcagta 689521 tttgcctgct gtatggggtt caatatacga cgggaacgga aagcggcatt ttgacaagca 689581 caacccccat gttgatcggt attttatcct ttttcctgct gagagaaaaa attgagaaaa 689641 agacgctgat cggcattttg ctggcggttt gcggcgtaat ggcgattaat ttgtttggag 689701 ccgggagcca agacgggacg ccgcacgcct tattcgggaa catgctgatc attgctgcag 689761 tcattggcga agcgttgttt acattgatgg ccaagctgct atccccgcat atttcggcac 689821 tggcgatttc gaccttcgta tcgctcttcg gcttcctgtt ttttctcccg tttgctttgt 689881 ttgaggcctc ttcatttgat tacagcgtgc cgactgtttt ggattggtcg tatgtgctgt 689941 attacgcgct ttttgtcact gttttggcgt tttacttatg gtatagcggg gtgacgaagg 690001 tgccggcggg tgtatcgggc attttcacat ccgttcttcc ggtctcagct gtcattttgt 690061 caggcgtgat attgaaggag ccatttgagt ttgtgcattt catcggcatt gcatgtgtca 690121 tcggcggcat atttgttacg gtcataaaga aaaaacagcc ggatgcgtat ccggctgcag 690181 aagaaaagac gctatagcct gtccggatcg gacgggtttt ttagtcttta aacacgctca 690241 gcctttcaaa aagatcacca agcatcttca cgaacatgtc tttttcctcg tcgctgtagt 690301 tttccatgac agcggatatt ttgctgaaat ggccgggcag aaattgctcc aggcgtgctt 690361 tgccttctgt tgtcagttca atgctgattt ttcgtttatc ctctgtgtga tgcctgcggc 690421 tgacaaaacc gtctctcgcc agcccgtcta gcaggcctgt aattgttgct ttcgtgacat 690481 ttgaccgctt ggcaagctct gtcggactta acctatgatc cttggcatca aagagcagca 690541 tcaggatttt gaattttcct tctgaaagcc ctcggccagc aaagtaatgc tccatcacat 690601 gattcatttt ttttgaaata tcaaaaagag ataaaaacaa ttcaagagag ccggcgtcaa 690661 tattggcata cgtttcggcg tgctctgtta tatgcttata tttcggtaaa tgttttaatt 690721 ccatcgcaat tagctcccgt acattcgttg tgacacgatt ataaaggagg gaaaaccata 690781 acgcaacttg gcttggagat gattgacagc ttttcttggg acatagtaag gtaatatagt 690841 taggcgccta actaatacat atagagctga aaaggtggtt attgatatga aacatatgtt 690901 aatagcagga ggcggaatcg gcggcttgtc agcggccatt tctctccgta aggcagggtt 690961 ttccgtcacc ttatgtgaag cggcttcaga aaatcgaaaa acaggtgcgg ggattcttca 691021 gccgcaaaac gcactggcgg tgttgaaaga actgggcgta ttcgaagatt gctgtaagca 691081 cggctttcaa acagaatggt ttaaaacgtt tgatgaacag gggaatttgc tgtttcaagt 691141 cagtgaatcc tttttagacg attcacttcc gggacgcaat aatatcctgc gcaaaacgtt 691201 aaatgacatt ctcatgaagc atgccgaggc agtgggtgta gacatcaagt gggggaaaaa 691261 ggttgtcgcc tatgaagaaa ctgctgaatc ggtcactgcc ttatgtgaag atggagaaaa 691321 gatgcaggct gacattctgg cgggctttga cggcattcac tccgttgttc gtgataagat 691381 gctgcaaaag gaaacggaaa aagagcatct cggcatggga gcgtggcgct tttatatcga 691441 acttcctgat tacacattcg aggacgcaac attcatgtat agaagcggag acacacaaat 691501 cggggtggtg ccattggcac aacacgctgg ctatgtcttc gtcctccagc cttgcacgag 691561 cgattactgg gatgaggaag atacccggtt tgatagagta aaagagattc tttctggttt 691621 tcgggggctg gattttgtca caaagcacat gtcaaaacag catcctgtca tctttaacaa 691681 actggagcag gtcgccgtgc aggagccatg gcataaaggc cgcgtcatca tcggaggaga 691741 cgccgcccac gccggtgcgc caaccctggc acaaggagcg gcaatggcga tcgaggatgc 691801 catcgtcctc gccgaagaac tccaaaacca cgccgaccac gaaacagcat tacaggcgta 691861 ctataaaaga agagccccac gagcgctcaa agtccagaac ctatcatctg aaatcgtccg 691921 ccgcaggctg aaaggagagc cgggagcgga agaactgatt ggggagtgct atgcggtgtt 691981 gagggaaggg tattaaatag gaaaagtcca gaaagtgatt tctggacttt ttagtcttgc 692041 tctgttttat tccttatccg ctcaatcacc tcatgcagcc cctcaggctt ataaaactcc 692101 accggtgaac tgcctttctc aaacgaaatc gtctcggctt caatcagcgc gacatagcgc 692161 ccgtttactt ttgcgagatg aatagaatcg ccaaaatccg ctagcaatcc cttaatctct 692221 gtttctccga ctttcatttt cagctgggcc tctggcgtgt gctcgatgat ttgggcggag 692281 gcttcgatga cttgatgggt gtcgaggcgc tcttggattt cccgtttttc gcttgcttcc 692341 caaatctcaa tgtcgtgctc gaactgcttg agttcttcgc tgttgtcttc aaatgtctcg 692401 tagacgtgct cttgtaccat gttcatgacc tgatttttca tgatttctgg catcgattct 692461 ccgtactcga cgaatttcag aaagtcctca aaatagcggg cgtgcgaggc ctggtggatt 692521 ttcagttcac cttcctcgac cattccttcc tctggcatgt acgggtattg gatgcttttc 692581 atgttttttg tcgtgatcgc catttcgact tttttaatga gagaagacgc gtcagagatg 692641 cgggcgacct tcggctcaaa atcacatttc ataatgaaga caaatgactc atcaaagtat 692701 tttctcggca cggccgaagc gacgagaaac acgccgccgc gaaccgcgct tgtgtcaagg 692761 tacgtgcgga cgaactgctc gctcagctca ttgaagtctt cttttgtttc cgccagacgc 692821 gcgcggttga acatgttgta gtttgggttg gaatcgagct cgtggccggg ctcgacgata 692881 aaatggccga ttttcgtcgg cacctgctcg gactgcggat ggcggtcggc tttccgttta 692941 acgatttttt tcagttcccc gtcgagaaag tccttcagct cgctttcttc aaattctccc 693001 gtatcaaggg tctggaagtg cttgaactgc ttgttcgcct gctcatcttt gccttccacc 693061 tgtatgacat aaaaggataa aaaccgaatt tcaaaatcca tatataaact caccttattc 693121 gcgtattgta cagcttctca agtatagaaa aaacagcgat catgcgtcaa ttgggagaac 693181 ggaataatca tgaccatgaa agggaaatgt agtcaaatag aaggcatttc atacggaaag 693241 gaatggttcg atgaaggaaa caagcccgat tcctcagccg aagacgtttg ggccgctcgg 693301 caatttgcct ttaattgata aagacaaacc gacgctttcg ctgatcaaac tggcggaaga 693361 acagggcccg atttttcaaa tccatacacc cgcgggcacg accattgtag tgtccggcca 693421 tgaattggtg aaagaggttt gtgatgaaga acggtttgat aaaagcattg aaggcgcctt 693481 ggaaaaggtt cgcgcatttt ccggtgacgg attgtttacg agctggacgc atgagcctaa 693541 ctggagaaaa gcgcacaaca ttctgatgcc gacgttcagc cagcgggcca tgaaggacta 693601 tcatgagaaa atggtcgata tcgctgttca gctcattcaa aaatgggcaa ggctcaaccc 693661 gaatgaagca gtcgatgtcc cgggagatat gacccggctg acgctcgaca ccattgggct 693721 atgcgggttt aactaccgct ttaacagtta ctacagagaa acgccccacc cgtttatcaa 693781 cagcatggtg cgggcgcttg atgaagcgat gcatcaaatg cagcggcttg atgttcaaga 693841 taagcttatg gtcagaacaa agcggcaatt ccgctatgat attcaaacga tgttttcgtt 693901 agtcgacagc attattgcag agcgcagggc gaatggagac caggatgaaa aagatttgct 693961 cgcccgcatg ctgaatgtgg aagatccgga aactggtgaa aagctcgacg acgaaaatat 694021 ccgctttcag atcatcacgt ttttgattgc cggccatgaa acaacgagcg gcctgctttc 694081 ctttgcgact tactttttat tgaagcatcc tgacaaactg aaaaaggcgt atgaagaggt 694141 cgatcgggtg ctgacggatg cagcgccgac ctataaacaa gtgctggagc ttacatacat 694201 acggatgatt ttaaatgaat cactgcgctt atggccgaca gctccggctt tcagccttta 694261 tccaaaagaa gacacagtca ttggcggaaa atttccgatc acgacgaatg acagaatttc 694321 tgtgctgatt ccgcagcttc atcgtgatcg agacgcttgg ggaaaggacg cagaagaatt 694381 ccggccggaa cggtttgagc atcaggacca agtgcctcat catgcgtaca aaccattcgg 694441 aaatggacaa cgggcctgta tcggcatgca gtttgccctt catgaagcca cacttgtgtt 694501 aggcatgatt ctaaaatatt tcacattgat tgatcatgag aattatgagc ttgatatcaa 694561 acaaacctta acacttaagc cgggcgattt tcacatcagt gttcaaagcc gtcatcagga 694621 agccattcat gcagacgtcc aggcagctga aaaagccgcg cctgatgagc aaaaggagaa 694681 aacggaagca aagggtgcat cggtcatcgg tcttaacaac cgcccgcttc tcgtgctgta 694741 cggctcagat accggcaccg cagaaggcgt cgcccgggag cttgctgata ctgccagtct 694801 tcacggcgta aggacaaaga cagcacctct gaacgaccgg attggaaagc tgccgaaaga 694861 gggagcggtt gtcattgtga cctcgtctta taatggaaag ccgccaagca atgccggaca 694921 attcgtgcag tggcttcaag aaatcaaacc gggtgagctt gagggcgtcc attacgcggt 694981 atttggctgc ggcgaccaca actgggcgag cacgtatcaa tacgtgccga gattcattga 695041 tgagcagctt gcggagaaag gcgcgactcg gttttctgcg cgcggggaag gggatgtgag 695101 cggtgatttt gaagggcagc ttgacgagtg gaaaaaaagc atgtgggcgg atgccatcaa 695161 agcattcgga cttgagctta atgaaaacgc tgataaggaa cgaagcacgc tgagccttca 695221 gtttgtcaga gggctgggcg agtctccgct cgctagatcg tacgaagcct ctcacgcatc 695281 cattgccgaa aatcgtgaac tccagtccgc agacagcgat cgaagcactc gccatatcga 695341 aattgcattg ccgccggatg ttgaatatca agagggcgac catcttggcg tattgccaaa 695401 aaacagccaa accaatgtca gccggattct tcacagattc ggtctgaagg gaaccgacca 695461 agtgacattg tcggcaagcg gccgcagtgc ggggcatctg ccattgggcc gtcctgtcag 695521 cctgcatgat cttctcagct acagcgtcga ggtgcaggaa gcagccacaa gagcgcaaat 695581 acgtgaactg gcgtcattta cagtgtgtcc gccgcatagg cgcgaattag aagaactgtc 695641 agcagagggt gtttatcagg agcaaatatt gaaaaaacga atttccatgc tggatctgct 695701 tgaaaagtat gaagcgtgtg acatgccgtt tgaacgattt ttagagcttt tacggccgtt 695761 aaaaccgaga tactattcga tttcaagctc tccaagagtg aatccgcggc aagcatcgat 695821 cacagtcggt gtcgtgcgcg gcccggcgtg gagcggccgt ggcgaataca ggggtgtggc 695881 atcaaatgat ttagctgagc gtcaagccgg tgatgatgtc gtgatgttta tccgcacacc 695941 ggaatcccgg tttcagcttc cgaaagaccc tgaaacgcca attattatgg tcgggccagg 696001 cacgggagtc gcgccatttc gcggtttcct tcaagcccgc gatgttttaa agcgggaggg 696061 caaaacgctc ggtgaggctc atctctattt tggatgcagg aacgatcggg attttattta 696121 ccgagatgag cttgagcggt ttgaaaaaga cggaatcgtc actgtccaca cagccttttc 696181 ccgaaaagag ggcatgccga aaacatatgt ccagcatctc atggctgacc aagcagatac 696241 attaatatca atccttgacc gcggtggcag gctttatgta tgcggtgatg gcagcaaaat 696301 ggccccggat gtggaggcgg cacttcaaaa agcgtatcag gctgtccatg gaaccgggga 696361 acaagaagcg caaaactggc tgagacatct gcaggatacc ggtatgtacg ctaaggatgt 696421 ctgggcaggg atatagataa agaagactgg agacatccag tctttttagt cctttcgaaa 696481 aaatggtgat cgcgctaaac attgatgcat acaataactt cagtccgccg gaagggcggg 696541 ctgtctgcaa aacctatttt tcgtttttgc tagtttatgt tattcttata ctcggtatct 696601 atttcttttt tcaaaggcac acatgacaaa agaaatcctt tttttatttc cgagaaaaaa 696661 atgtgaaacg aaatgaaggt ttctttcgtc cagtgattgg tttccaaatg gttgtaataa 696721 aaatgatatg gtgcgaaaca taaatattcc ggcttgccgc ggtgtattta ttgttgtgtg 696781 atgccttgat tttgtttgga aagaaggaat tggaaggcag gatataaaga gcaggtaaat 696841 atgaatgaag aacttaaagt gtttaagaaa gtagaggttg ccatgaagaa acttttttct 696901 tacaaactta gcttttttgt gctggctgtt atactgtttt gggcaaaaac gtatttatcc 696961 tacaagactg agtttaatct tggggtaaaa ggcacaactc aggagatcct cctgatattt 697021 aacccattct caagcgccgt cttcttttta ggactggctt tgctggcgaa agggcgtaaa 697081 tcagccatta ttatgctgat tatcgatttc ttgatgacat ttgtgttata tgcaaatatt 697141 ttattctatc gtttctttga cgatttcttg acgttcccga acattaaaca gtccggaaac 697201 gttggaaaca tgggagacgg gattttcagt atcatggccg gtcatgatat tttctatttc 697261 ttagatatta tcattttgat tgcggtattg atctggagac ctgaattaaa agaatacaaa 697321 atgaaaaaac gctttgcatc tttagtgatc ctttctggga tcgcactgtt tttcatcaac 697381 ctgcactatg cggaaaaaga ccgtccgcaa ctgctgacaa gaacgtttga ccgcaattat 697441 attgtgaaat atttaggttt atacaactac accatttatg acggtgtaca gacggctcaa 697501 acagagacgc aaagagccta tgcaagcagc gatgatttaa caagtgtcga gaattacacg 697561 acgtctcatt atgcgaaacc aaacgccgag tacttcggct ctgccaaagg caaaaatatc 697621 attaaaattc acctcgaaag cttccagtca ttcctgattg actacaagct aaacggtgaa 697681 gaggtgacgc ctttcttaaa taaacttgcg cacggcgggg aagatgtgac gtattttgat 697741 aacttcttcc atcagacagg ccagggaaaa acatctgatg ccgagctgac aatggataac 697801 tcgatcttcg gtcttcctga aggctccgcg tttgtgacga aaggcgaaaa cacctaccag 697861 tcgcttcctg cgattttaga ccagaaggaa ggctatacaa gcgccgtcct gcatggtgat 697921 tacaaatcgt tctggaaccg tgaccagatt tacaaacata tcggatatga caagttcttc 697981 gacgcaagca cgtatgatat gtcagatgaa aatgtgatta atatggggct taaggataag 698041 ccgttcttta cagaatcgat tccaaagctt gaatctctta aacagccatt ttatgcgcat 698101 ttgattacat tgacaaacca ttatccgttt aaccttgatg aaaaagacgc gtctcttaaa 698161 aaagcgacaa caggcgataa cacagttgac agctacttcc agacagcgcg ttaccttgac 698221 gaagcgcttg agcaattctt caaggagctg aaggaagccg gcctgtatga caactcagtc 698281 atcatgattt acggtgacca taacggtatt tctgaaaacc ataaccgagc gatgaaagag 698341 attcttggaa aagagatcac agattatcaa aacgcacaga accagcgtgt gccgctgatg 698401 atccgcgttc ctggcaaaaa aggcggagtg aaccatacgt atggcggcga aattgacgtc 698461 atgccgacac ttctgcactt agaaggaatt gattctcaga aatatatcaa ctttggtact 698521 gatttattct ctaaagacca cgacgatacg gtggcattca gaaacggaga cttcgtaacg 698581 ccgaagtaca catcagtcga caatatcatt tacgatacga agacaggtga aaaactgaaa 698641 gcgaatgaag aaacgaagaa tctgaaaaca agagtgaacc agcagctgag cctttcagac 698701 agtgtcctgt acaaagactt gctgaggttc cataaactaa atgatttcaa agccgttgat 698761 ccgtcagact atcattacgg caaggagaaa gaaatcaaat aagatgaaaa agagccttga 698821 gcgggcgcat tgccttcgct caaggctctt tttttggtta tacaaccaac ttgaaaaaat 698881 agattccatt tggtcaccaa ggctggcttt ctctcatatc attacagtag attttgaaac 698941 cggattgaaa tcggacaaat tatcggggaa atgccttgat agattgtgaa gatgtaccag 699001 gtttcgaact caatattcat agagatgagg ggtagagatg aaagcggtca ttctctgcgg 699061 cggaaaagga acgagaatga gtgaagtcac gaatgacatt cctaaaccgc tcgccatgat 699121 aggcggcaaa ccgattctat ggcatattat gaaaatttat cagtactacg gagtaaacga 699181 gtttattctg cttttgggct ataaaggaga aaaaatcaag gaatactttc tcgactatga 699241 atggaagcac aacagcctga cactcgacag ctctacggga gaggtacaga tgctggggca 699301 gcctgaaacg tggaaaatta cgtttttgga gactggggta gatacgctga cagccggaag 699361 aatcttgcag gcgaaagact atatcggtga tgaaacattt ctgctcacct atggagacgg 699421 gctggccaat atcaatcttt tccatctcat cagctatcat cagacaaaag gtgctgccgc 699481 gactgtcacc ggcattgaca aagtctcgca gtttggcacc ttgacagttg aggatggcat 699541 ggcgaaaaca ttttctgaga agacatcaag tgatggaatc atcaacggcg gattcttcgt 699601 tcttagtcca aaggttttcg attatttgcc gaaggacggg aacacgatgt tcgaagatga 699661 accgctgaag aaccttgcca aagatgggga gcttgctgtg taccgccatt acggattttg 699721 gacggccatc gatacgtata aaaatctctt agaagtcaac aaaatgtgga atcaaggaca 699781 acaagtatgg aaggtatggt gaattgattt gagtttctgg aaaaataaaa acgtatttgt 699841 cacgggatgc acaggtcttt taggaagcta tttggtgaaa gagctgatcg aacagggcgc 699901 aaacgttacg gggctagtca gggatcatgt gcctcaatcc aatctttatc agggagaaca 699961 tatcaagaaa atgaacatcg tgcggggctc tcttgaggac ttggctgtga ttgaacgcgc 700021 gcttggcgag tatgagatcg acacagtctt tcatcttgct gcacaagcga ttgtcggcgt 700081 ggcaaaccgc aacccgattt ctacctttga agcgaatatc ctcggcacct ggaatattct 700141 cgaagcctgc cgcaagcatc cgttaattaa gcgggtcatt gtcgcttcaa gtgataaagc 700201 ttacggcgat caagaaaacc ttccatacga tgaaaacatg ccgctgcaag gcaagcaccc 700261 gtacgacgtc tcaaaaagct gcgcagatct gatcagccac acctattttc acacgtacgg 700321 gcttccggtc tgcattacgc gctgcggaaa cttatacggc ggcggagatt tgaacttcaa 700381 ccgcatcatt cctcagacga ttcagcttgt gctgaacggg gaagcgccgg aaatccgaag 700441 cgacggcaca tttgtacggg actacttcta tattgaagac gccgttcagg cttatctgct 700501 tcttgcagaa aaaatggaag aaaacaatct tgccggagag gcctttaact tcagcaatga 700561 gatccagctg accgtacttg aactggtaga gaaaatatta aagaaaatga acagtaatct 700621 gaaacctaag gtgctgaatc agggaagcaa tgaaatcaaa catcaatatt tatccgcgga 700681 aaaagcaaga aagctgctga attggacacc ggcctacact attgatgagg gacttgaaaa 700741 aacgattgag tggtatacgg aattcttcaa aaagtaatgt gaaacgaggt gaacaagact 700801 gtgaccagcg cgtattgcac cgttttatca aaaggaagat tatatcaggc agtcgctttg 700861 tttaagtcgt tagagcaagt tgatcaagac agtcccattt ttatactttg catggatgaa 700921 gatacgcacc gcgtgttaca gaagctgaag atgaagcagc tgaaccttgt gccggtggcc 700981 gctcttgaaa atgaattgct gctgaagctg aaggaaacta gagatcaaag tgagtattgc 701041 tggacgatga agccgatctt tctgcaagct gtgctgaaca gcaatcctga gctggagcgt 701101 gtgacgtata ttgacgggga tctctttttc tatgcagatc catcgccgat ttttgaaaac 701161 cagccggact gctcggtgtt gctttcacga ggggatattg taatcccttc ttttgagaaa 701221 gagcagattg acatgctgca gcgtctttta ggcagatata attccgggtt tatcagcttc 701281 aagcatgatg atgcaggcac ggattgcttg gagtggtgga aggaacgctg tcttgaggaa 701341 tgcaaaaatg caccgggtga agggaaattc ggtgatcagg gctatttgga ttatatgtct 701401 gagctgtttc cgaatgtgtg tgacattaca acacccggcg tgaacatcgg ccattggaat 701461 tatggacagc atacgttttc ctggaaagat ggccggatcg tgctggagga tggcagtccg 701521 ctgatctttt atcatttcag cggataccga atcgtcagca tcaatgaaat caaacagatt 701581 catgaaacaa cccgcacaga tctgccgttt gtgcatgaac tgtatcaaga gacactgccg 701641 catatcattc agcacatgca aacgttagac cctgaattta acggttttgc ttcaaaagat 701701 gacaacaaat aaatgagtaa atacaggaag tgaaaatgaa gtgaaagcaa gcgttattat 701761 tcctgcatat aattcgaagg agcgtcttta caacagcctt ctgtcattaa accagcagga 701821 gtgcgatgaa gaatttgaag tcattgtagc ggacaatggc tctgaggacg ggacgctctc 701881 gatgcttgag tcatttcaag ctgattttcc gctgatcttt acacggatta aagaaaacag 701941 gggcattgcg tacggacgaa atcaggcgct tcgcaatgcc agaggagaca tcctgatttt 702001 ccatgacagc gatatgcttg cggcaaagga ccttgtggca aaacatatta aagcccatga 702061 gaacgaagag aatctcgtcg tgtgcgggtt gttttggaaa cggatctaca gtttttacta 702121 tgaacgattt gaagaagaac ataaggaaca gctcgcaaag ctcacaggtg aaatgccgaa 702181 gaaagacaaa caaaagctgc tggaggaagc ggacatcaaa aacggaagct ttcttgataa 702241 aagctttgac ctcgataccg actttataga cgtgctcaag aagattttag atgagtacgg 702301 cgatgacttg aaaggctatc atatgccatg gcgctttttt atcacgaata attcctctgt 702361 gaaacgcaag catgtggttg acctcggttt atttgacgaa ggcattgtgc ggtacgggtt 702421 tgaggattat gacctcggga tcaggcttca tcaggccgga ttgaccttca ggcttcgccg 702481 tgatattgtc agtgttcatc aggaacatcc aagcaattgt aagtctgtag acgatattcg 702541 ggcaaacatt gcctatatgt gcgataaata caataacatc cgctccttag acgttcatct 702601 cgcttttaat gggccgttcc cgcctgacat gacgaacaga atcatggctg atattcaaaa 702661 gctgctggaa tcacagaaat atgatatgct gctgaatctg tttcttgagc ttctgcatgt 702721 tgttaaagag cgcaacattg atccggattg gcgaaagaaa tccccaaggg tgacggcgaa 702781 aagctttgat ttgcaaactg tccgcaagct tctgcctaag gcgaagaaaa agctaggcgt 702841 gaacgatttt gccaacgcac tgtatgcgct tgtcaacgat ttgctgcacg tggatcttag 702901 atcattggat gtggtataag tgagtacatt tcatttttca acgatagtgt caaggacaca 702961 tatctttaag ctcatgccta tgattcattc tctccatgag cattgcgatg attttcattt 703021 atatgtgctg tgtgtcgacc agaaagcgta tgaattgctt cagcacgttc catgggagca 703081 tgtaaccttt gtgcagctgc atgaaatgga agacccggag ctgttgaaag cgaaaagcaa 703141 cagaacgttt catgaatatt gctggacgtt aaagcccgcc tttttgtttc atgtgatgag 703201 caagtgggat gacgctgaat actttgccca tatggatacg gatctatttt tcttttctga 703261 tccggcacgt atttttgcag aaaacccaac ggcgtctctg tatttgactg atcatcgtaa 703321 ttcgccgcgc ttcatgtcct actacgaccg aaccggacgc tttaatacag gctttgtcgg 703381 cgccggtaat acaaaggaag catatgaagc ggtgtggcag tggagacagg actgtattga 703441 attttgcacg gtcgaaatgg atacggaacg aaagacatat ggtgatcaaa gatatgtgga 703501 gaaatggccg gagcagttta aaggtgttca tgttgtcaaa tccataggag ccaatacagc 703561 gctttggaat atcgaaaact ataaggtcgg gcaaaaggac ggccgcgtgt atatagatga 703621 aacgccgctg attttctatc atttctctgg gtttacgctg gtgacagaaa aagagtttaa 703681 tctttgctgg tactaccgga ttgaagacga agcgacaatt aagatgattt atatgcccta 703741 tatattaaat ctgaaaagat ggattgatga aatacagtcg gcgtttccgg actttgcgga 703801 tggctttatc ccgaagcacg cagtgcctga cactcatttt atccagctgg attaaaaaac 703861 cccctgccgc ctggcagggg ttttttcagc tatgccattc tctcagcttc tggtcacttg 703921 gcaataggaa ggcaaggatg ccgaggacag ggagaaaggc aatggcgatc atcgtcgggg 703981 tcagtcccgc ggcatcaatc agagcgccca gcgccacagc gccgattgcg cccatcccga 704041 aggcaagccc gacggttaaa ccggacattg tgccgatttt tccaggaact agctcctgtg 704101 cgtagacgac cgttacagaa aagctcgaca tcagaaccaa gccaatcaat gcgagcacgc 704161 cgtaggcgag aaccgggccg gcaaatggca gcacaatcgc cagcggcgcc gagcataaca 704221 gcgaaccgag gataacgaag cgttttccaa aacggtctgc aagcgggccg ccgagaaacg 704281 tgccgatcgc gccgaacagc aagaagacaa aaatatagct ttgtgcctgc tgaatgctta 704341 cgtgataggt atccatcgcg taaaacgtgt aaaagttacc gatcgcactc gtataccaag 704401 aacgagcaaa aatgagaaat ataataataa taagagcaga tacaacagat ttggtgatgg 704461 ccgtgttttc agccgttttc ttttgcttgc ctgatttctg ggcaaggctg ccgagacgtg 704521 aggcgtacca tttcgcaata tacatgagaa acataacagc aagcgcggcg acaagcgtga 704581 accaaacagc gccgaattgc ccgagcggca caaggatcag cgcggtgatc agcggtgcca 704641 tcgcctggcc tgagtttccg cccacctgat aaatcgattg ggcgagcccg cgttttgtgc 704701 cggcggccat atacgccaca cgggagccct ccggatggaa aatggccgag cctaatccaa 704761 tgaaaaacac acagcataag atcgttatga atgacggggc aaatgcaagg cccaaaatgc 704821 caagcatgct ggcggtcaaa ccgactggca gcgcatacgg ccgcggccgt ttatcggtat 704881 accagccgac aacaggctgc atgacggatg acaccatgtt taatgtgaaa gcaatgatgc 704941 cgagctgtgt aaacgtcagg ctcatggagc gttccaaaat agggaacatg gccggaatca 705001 cagcctgaag cgaatcgttg agcatatggc aaattccgat aataatcaaa atcggataca 705061 ccgtggtgcc tggtttttga actgtttttt cttttaacgg ggcggcgata gccattgagt 705121 ctcctcctta catatataac caaagcatac caccatatta ttcataaggt gaagaattta 705181 tcaagaggaa aaaagattct tatgaaagaa ataccgtcag cctgattagc agctgacggt 705241 attttcgata ttcaaaatgt gatatagctc ttcaagctta cgaatctcat aggttggtat 705301 gatctctggc acattcggct tcatgtcagg gttcatccag caagtatcaa gcccggcgag 705361 ctgtccgcct ttgatatcag cagttagtga atccccgatg attaatgtgt gctctgctga 705421 aaattgagga atccgttcaa acacgtaatt gaaatattcc ttcatcggct tttggaagcc 705481 ggtgtcttca gaaacgaaaa tgtccttgaa gaatggaaat aatcctgaat cacggagacg 705541 cttatattgt gtgtgagaca cgccgtttgt cacgatgtac aaatcaaact gttgctgcag 705601 atttgagatg agatcaaatg caccgtcaat aagctgatgt ccttcttcaa gaaagcggcg 705661 gtatttttgc tcaagcaaag cgccgtccgc ttcgtaaccg tactccttga gcaaagcgga 705721 aaaacgtgtg tttacgactt catcccgtgt catcttacct tcttcaaagg ctctccagag 705781 accttgattg atggttttat actgcgcctt catgtcattt gttaaaggaa tgttctgatc 705841 ttcaaacagc aaacgcaggg ctaaagcttc tgccgcttga aaatcaagga tggtatcatc 705901 tacatcaaat aataaagtgc ggtatcgctt catctgtgtg tctccctttc tcatatgtat 705961 tcaaagtata gcacataaaa aaaggaaaaa gccggcgggt gaggcaccgc cggctgaaaa 706021 gagattattt gtttaataag ctgtgttttc tcgaatatag gaagtaaacc agcgttccga 706081 cagcgatcca gatgacaaat gaaagccatg tgacgccggg aaggctgtac atgaaccaaa 706141 ggcagatgcc tgcgctgata atcggcacaa ccggaacgaa tggcactctg aaggacgctt 706201 tgatttcagg atgtttcttt cttaacacaa tgacagcaat ggaaatgacc gtaaacgcgg 706261 caagtgttcc catgttcacc agatgggcca gcgttccgag gttaataaag ccggcgattc 706321 ccgctgcaac gatccctgtc agccatgtgt tgcggaacgg ggttttaaat gacggatgaa 706381 cctttgcgaa caatccaggc agaaggccgt ctctgctcat ggcaaatgtc aagcggacct 706441 gtgcgtacag caaagcgagc atcaccgtcg taatcccgat aatcgcaccg acagaaataa 706501 ttccggcaac agcgtcctgt ccgacgaatt tcagcgcaaa ggatacagga tctccgacat 706561 tcaatttggc ataaggcatc atgcctgtca gcacaagcga taccgcgatg tacagaaccg 706621 tacagacggc tagagctgaa ataatgccga cgggcatgtt tttttgcgga tttttcactt 706681 cctctgatgc gttagaaacc gcgtcaaacc caaggtacgc gaagaataca gtggcagcgc 706741 taagtatgac gcctttcatc ccgaatggca taaaaggaga ccagttatcc ggtttcacat 706801 agccgatgcc gacaataatg aacaataata tgatcgcgat tttcatcagt acgatgacgt 706861 tgttaaagcg tgtgctttcc ttgacgcctc tgctgacaat cgcagtgatg aggagaatga 706921 tcaccgcagc cggaaggtta aatacggcgc ccgccatgct tcccggcgct cctgtcagtg 706981 cagccggaat atgaagattg aagccggcaa gcagtgattg aaagtatgaa gaccagccgg 707041 tggcaaccgc cgacagtgca atgacatatt caagcatgag atcccatccg atcaaaaagg 707101 cgagcagctc tccaagtgtc acgtatgagt atgagtacac gcttcccgaa atcggaatgg 707161 aagacgaaaa ctcagcataa cagaaagcag ccagcgcaca ggcgagcccc gctaaaataa 707221 acgatatgat gagggcggga cctgcaccgg tcgctgccac tgttcctgta atgacaaaaa 707281 tccctgtacc gatgacacaa ccgataccga gcaaggttaa atcaaatgcg cttaacgtac 707341 gggcaaggct ttttgacttg ctctgcgcac tcaatgtttc aagcggtttt tttctaaata 707401 atgaactcat caaaagttcc tcctagaaat attcaaaata ttctaatcat tatatgcagt 707461 tcttgttgta ttatattgtc gaaatttgac gtagtcaata aaatattttt ctgctttaaa 707521 tgatagaagc gaaacagcgt tgtcgtatca taggatagta atttttacta atcgtatatt 707581 caattttatg caagatgaac cgatagaaaa aatagattcg cccatatttt gatttgcggt 707641 tataaaggag atgctgacca tgtttcaata tgaagagttg aataaacagt ttatcggcgg 707701 gaaatggcag gagggcagca gcccaaatgt attggaaaac aaaaatcctt atactcaaaa 707761 aacattcaca acattccgta aagcgactgc tgacgatgta gatgaagcgt atcgggcagc 707821 ggcgctggca aagaaaaaat gggatgcggt caacccgttc gagaaaagaa ccattttaga 707881 aaaagccgtc acgtatattg aagaaaatga agaagccatt atttatttga ttatggagga 707941 gctaggcggt acaaggctca aagcagcttt tgaaatcggt cttgtcaaaa acatcataaa 708001 agaagcggca acgttcccaa tccgcatgga ggggaaaatt cttccgtcaa caatagatgg 708061 caaggaaaac agattatatc gcgtgccggc aggcgttgtc ggtgtcatca gtccgtttaa 708121 cttcccattc tttttatcta tgaaatcagt ggcgcctgca ctcggagccg gcaatggcgt 708181 tgtgctaaag ccgcatgagg aaacgccgat ttgcggcgga acgctgattg cgaaaatttt 708241 tgagaacgcg ggaattccag cggggctgct gaatgttgtt gtcacagaca ttgctgaaat 708301 cggcgacagc ttcgttgagc atccagtgcc gcggatcatc tcatttaccg gttctacgaa 708361 agtcggcagc tacatcggac agcttgcgat gaagcatttt aaaaagccgc ttcttgagct 708421 tggcgggaac agcgccttca tcgtacttga ggatgcagat atagaatatg cggtcaatgc 708481 ggcggtgttc agccgattta cacatcaagg gcagatttgc atgtcagcca accgcgtgct 708541 tgttcattct tctatttatg acaagttcct tgagctgtac caggcaaaag tggaatcgct 708601 gaaagtcggc gacccaatgg accctgatac gattatcggg ccattaatca acagcagaca 708661 gacggacggg ctgatgaaga ctgtagagca agcaattgaa gaaggcgctg taccagtgaa 708721 gcttggcgga tttaacggga cgatcgtgga accgacgatc ttaaaagacg tcaaaccgtt 708781 catgagcatt gccaaggaag agctgttcgg accagtcgtc tcctttatga agtttgattc 708841 agaagacgaa gcggtggata tcgcaaacga aaccccgttt ggcttgagcg gtgccgtaca 708901 tacgtcaaat cttgagcgcg gcgtggcttt tgcgaaacgc attgaaacag gcatgattca 708961 cgtcaatgac acgaccatca atgatgaacc gaatgtagcc ttcggcggtg aaaagcaatc 709021 aggcctcggc cgtttaaacg gtgagtggag cctcgaagaa tttacaacgc tgaaatggat 709081 ctcggtccag cacgaaaaac gcagcttccc ttattaatga aaaggagtga atggaattga 709141 ccataaatac ggaaaaagaa accgcagata ttctggacgc atttatcaaa gtagcccctt 709201 atttaaacag cctggttcag gatgatatta caatcggcat ttatgatacg gaaaaactgc 709261 tcgtgaatat accggccaaa accttttcgc tgaacgtaaa agccggcgat ccgctgcagg 709321 aaggggatat catcacagat gccatccgca gcaatcagaa gaagacgagc atggttccga 709381 aagaattgtt cggcttccca ttgatcgcgc gtgccatccc gctgcacgac gagaatggaa 709441 gagtcattgg aggcgtcggc ctcggaacga gccttgagga gtcgtcaaag ctgcatgatg 709501 tcgcggaaag cttatcagct gttgttgaac aaacagccgc ggctatttcc gacatttctg 709561 aatcaattaa cgggttttca actcaaatgt cgggcatttc ctctcaggcg aaaaaagtaa 709621 gcgaaagcgc cggtgaaatc gccgatattt cagtaactgt taaaggcatc tcggaccaaa 709681 gcaatctgct cggcttgaac gccgcgatcg aagcggcaag agcaggggag tccggaaaag 709741 gattctctgt cgtcgcagat gagatcagaa agctagcgac gcattcaaaa gaaaatgtcg 709801 gccaaattga ccagattacg aaaaaaatcc acagcctgct gaaagggctg gaggaatcca 709861 ttgagtcgat taaccagcat acagacggac aagccgctgc tgttgaacaa atttccgcca 709921 cgatgcagga gatttcagga agcgcgcagc atcttgcgaa aatggccgaa aaagcgcttg 709981 aggaagagta agagaccggg gacaaacatc cccggtcttt ttcttatcct gcatttccat 710041 gaaattcgtc tgacgtttta ctagttttat tccagcggct gatttaaaat gtacacatga 710101 acttacgtga ggattgatag gaaccatgag catattaaaa gcggaaaatc tttataaaac 710161 atacggagat aaaacattat ttgaccatat ctcctttcat attgaagaga atgagagaat 710221 cggattaatc gggccgaacg gaacaggaaa atcaacgctg ttgaaagtga ttgccggctt 710281 ggaatctatc gaagaaggag aaatcacgaa atccggaagc gtgcaggtcg aatttcttca 710341 tcaagacccg gagctgcctg cggggcaaac agtgctggag catatctatt ccggtgaatc 710401 ggctgtgatg aaaaccttgc gtgaatatga aaaagcgctg tatgaactgg ggaaagatcc 710461 cgaaaatgaa cagcgccaga aacacctgct ggcagcacaa gcgaaaatgg acgcgaacaa 710521 tgcatgggat gcaaacacct tggcaaaaac cgtattgtct aagctgggcg tcaacgacgt 710581 aacaaaaccg gtcaatgagc tctcaggcgg ccagaaaaaa cgggtggcca ttgccaaaaa 710641 cttaattcag cccgctgatt tgctcatttt ggacgagccg acaaaccatt tggataatga 710701 aacgattgag tggcttgaag ggtatttaag ccaatatccc ggcgccgtca tgctggtgac 710761 gcacgataga tatttcttaa accgtgtcac caaccgcatt tatgagcttg aaagaggcag 710821 cctctacact tacaaaggca actatgaagt gtttttagaa aaacgcgcgg aacgggaagc 710881 gcaggctgag caaaaggaaa cgaagcggca aaacctgctg cgccgcgaac tggcttggct 710941 cagacgagga gcgaaagccc gctccacaaa acaaaaagcg agaattgacc gggtagagac 711001 gcttaaagag cagacaggcc ctcagtcatc aggttcactc gattttgcca ttggctcgca 711061 ccgtctcgga aaacaggtta ttgaagcgga gaacgtcatg atcgcttatg acggccgcat 711121 gctcgtcgac cgttttaatg aacttgtcat accaggtgaa cggatcggga tcatcgggcc 711181 gaacggcatc gggaaaacaa cgctgttaaa tgcccttgcc ggccgtcata cgccggacgg 711241 aggcgatatt acgatcggac agacggtcag aatcggctac tatactcagg atcatagtga 711301 aatgaacggt gagttaaaag tcattgacta tataaaagaa acggcggagg tcgtaaaaac 711361 ggcagatggc gatatgatta cagctgaaca aatgctcgag cgtttcctct tcccgcgttc 711421 gatgcagcag acgtatatcc gcaagctgtc cggcggggaa aaacgccgtt tatacttgct 711481 tcaggttctc atgcaggagc cgaatgtcct gtttctcgat gagccgacga acgatttgga 711541 tactgaaaca ttaagcgttc ttgaggatta tattgaccag ttcccaggcg tcgtcatcac 711601 cgtatcccat gaccgctatt tccttgaccg cgtcgtcgac cgtttgattg tatttgaagg 711661 aaatggtgtc atttcccgct ttcaaggctc ctatagcgac tatatggagg agtcaaaagc 711721 gaaaaaagcg gccccaaaac cggcagctga ggaaaaaacg gctgaagccg agccgaagaa 711781 aaaacggaaa aagctttctt acaaagacca gttggaatgg gacggcatcg aagataaaat 711841 tgcccagctg gaagaaaagc atgaacagct tgaagctgac atcgccgcag caggcagtga 711901 ttttggcaaa atccaagagc tgatggccga gcaggcgaaa acggcggaag agcttgaggc 711961 tgcgatggac cgctggacag aattgtccct catgatcgaa gaactggaaa gctaaaaagc 712021 gtggccgcag caggccgcgc tttttttcac ataatggaca aaaacgaacc ggcctgctta 712081 tgttaggata aagttgtgtg tcagcggcac atggaaaact aacggagatg atgaagtatg 712141 acatgggcga tcgtgatgtt aattctcatg agtctggtga aaatcgtatt aacctgtctt 712201 cctacaggcg tcatagaatg gctgctcggc aaatttgaag tgcacgccaa gctgagtgac 712261 gaaaatgcga gtctctctct agatggaaaa cgcctcgagg gtgcagagaa gcagaaagtg 712321 attgatcaat ttaacgaagc tatcttcctg gaaaaatatt atatctatcc aggtgatgaa 712381 gagcgttatt tacatccgga aaacggcggc acgcctctgg tgatagatac aaaaaaagga 712441 aaaaaagacg tgaagctgtt cgtgtaccgc tacgacgacc atatcgacgt cgtgaaacag 712501 tacaagaaga aagtgatcgc gtatcgagtg ctttctgaaa gccttcaaaa agagtctctg 712561 tcagtggcgg gaagtttagc ttaaacagga aagtgaaaga cgggtgctgt atgctgctcg 712621 tcttttttat tgttttttaa aacttaacgt ttacgttaag gttcaaaagg tgtataatgg 712681 taacagaaac ggcgaagggg gatttacctt ggaatggatg aagattgatc aagtggccaa 712741 aagaagcggg ctgacaaagc ggaccatccg gttttatgaa gaaatcggct tgattccggc 712801 gccgaaacgg acagacggcg gtgtaaggct ttattcagag gatgatatgg aggagcttga 712861 gaaagtcatc agcacaaaag aggtgctcgg tttttccctt caggagcttc agcatttcat 712921 ggaaaccagc cgccagctag agttaaacaa agaggggtat ttgttgtcac tggatcctaa 712981 ggaacggaaa gaaaaactgg aggaaattca ggaaaccctg aatcaccagc tggatttgat 713041 tgatgagaaa atccgcacat tccaaagctt taaagaacgc ctgcagggca tgaaaggcaa 713101 agcggaacgc gccattcaat caatcgaatg aaaagtttgt taaacgctat ttttgtagcg 713161 tttcttttaa tggaataaag atggaggtta ggtcaaatgg ataagacaac acaagtgaat 713221 cagaaaacgg gtttgctcag ccagccaaaa gcggtatggg ctgtcgcgtt tgcctgtgtg 713281 atttctttta tgggaatcgg gctggtcgat ccaattcttc cggccattgc cgcacaattg 713341 catgcttcac ctagtgaagt atcactcttg tttacaagtt atttgcttgt aaccggattt 713401 atgatgtttt tctcaggagc catttccagc cgcatcggcg cgaaatggac attaattctc 713461 ggacttattt ttattattgt gtttgcgggg cttggcggca gctcaagctc aatcgctcag 713521 ttagtcggct atcgcggcgg ctggggatta gggaatgctt tgtttatttc aacagcgctt 713581 gcggtcatcg ttggcgtgtc agtcggcggc agcgcccaag cgattatttt gtatgaggcc 713641 gcgctcggtc tcgggatttc tgtcgggccg cttgcaggcg gagagctcgg aagcatttca 713701 tggcgcgcac cgttttttgg agtatctgtc ctgatgttta ttgcgttaat cgcgatttct 713761 ttcatgcttc cgaagctgcc gaaaccggcg aaacgcgtcg gtgtgtttga tgcgatgaag 713821 gcactcaaat ataaaggcct gctgacaatg gcggtatcgg cattcctata caactttgga 713881 ttttttattt tgctagctta ttctccgttc gtactggatt tagatgaaca cggtcttgga 713941 tatgtcttct tcggctgggg ccttctgctg gcgattacgt cagtctttac ggcgccgctc 714001 gtgcacaaag cgctgggcac agtgcgttcg ctagtcgttc tctttatcgc ctttgcggcc 714061 attctcgtta ttatggggat ctggacagac catcagactt tgattattac atgtatcgtt 714121 gtcgctggtg ctgtcctcgg tatggtgaat acgatcatga caaccgctgt gatgggttct 714181 gcgccggttg aacgttcaat cgcgtcttca gcctacagct cagtccgctt catcggcggc 714241 gcgctcgccc cgtggattgc aggaatgctg tcagaacact ttactgcaag cacaccatat 714301 acagtaggcg gaatcgtcgt ttttgtcggc atgcttgtcc ttctcatggg acgtaaacat 714361 cttgctggaa ttaaggcggg gcattaataa cgaaagacac tgcgcatatg cagtgtcttt 714421 ttattcgtta taatgcatca taatcgaatt ggtgcaggaa aggacaacct ttatgacaca 714481 attttactat tttccggctg aaaactccct ttagaaaccg gttttttcgg tcagcaagaa 714541 cggcgttcgc ggaaagggca tccgcttcgg tcaggcattg atgcggctgg gatttatctt 714601 gcagaagctg agaatgtgtc cgttcattta cgattgccat ttcagtgatg gttcatgctg 714661 tagaggggac gtttgccatg gataaggcaa aacctgacga atatgatcag aaatgtttag 714721 aaacgctcta tcaatacata cacagcgtca tgaaaaacag cttttctcgg tcgagtggtt 714781 taccgcttgg gaagatgagg aggattttga gctgtctgcc aaaagagagc tgacacttga 714841 tgaattcaca tctccattgc agctcatttt aaaagacaga gagcttttga gaatcgttca 714901 gaaaaaatgg cagtaaaaaa cccgcccttt agcaggcggg tttttttata aattaaagca 714961 ctttcgtcgt ccaagactcg cagttccacg tttctgtcgc aatatccata taaaagtctg 715021 gctcgtggga aatgagcaga atggagcctt tatattcttt cagggcgcgc ttgagctctt 715081 ccttggcatc ggcatccaag tggtttgtcg gctcatcgag caccagcagg tttgtttctg 715141 agttgattag cttgcacaat ctgactttcg ctttttcgcc tccgcttaat acggagacgc 715201 ggctttcgat atgctttgtc gtcagcccgc attttgccag agcggcacgg atttcatact 715261 gcgtataaga agggaattcg ctccatactt cttcgatgca cgtattgttg tttgtttcct 715321 tgacctcttg ctcgaaatag ccggtataga tgtgctcacc gcgttcaaca gagccttcga 715381 gcggctggat ttcaccaagc aaacttttca gcaatgtcgt ttttccgatc ccattcgcgc 715441 cgtaaagggc gattttttgg ccgcgctcca tgcggaggtt gagcggacgg gacagcgggg 715501 aatcgtaacc gatcacgaga tccttcgttt caaaaatcag cttgcctgac gttctcgccg 715561 gcttaaagtg gaattccggc tttggctttt ctgccgcaag ctcgatcata tccatcttat 715621 cgagtttctt ttggcgggac atcgccatgt ttctcgtgct gacacgcgct ttgttgcggg 715681 cgacgaaatc cttcagctcc gcgacttcct gctgctgctt tttgtaggcc gcttcaagct 715741 gctgtttttt cacctcgtag acttccataa actgatggta gtcgccgaca taacgtgtca 715801 gctcttgatt ttcaacgtga taaatcaggt tgatgacact attcaagaac ggaatatcgt 715861 gggaaatcag gatgaacgcg ttctcgtatt cctgcaggta gcgtttcagc cattcaatat 715921 gctgttcatc aagatagttg gtcggctcat cgagaagcag aatttccggc ttttcaagga 715981 gaagcttagc gagaaggacc tttgtgcgct gtccgccgct caaatcggtg acatctcgct 716041 ctaaaccgat atcgctcaaa ccgagaccgc gggcgatttc ttccaccttg gaatcaatga 716101 cataaaaatc attgtttgtc agcgcgtctt gaatgacgcc gacttcttca agcagcttct 716161 cgagctcgtc gggatcagcc tcgcccattt tgttgtaaat ctcgttcatt tcctcttcca 716221 tcgcaaataa ataatggaat gcgtctttca ggacgtcgcg aatggatttt cctttttcca 716281 gcacggtatg ctgatcaagg tatccgacac ggacattttt tgaccattcg acttttccct 716341 catcaggttc aagctttccg gtaataatat tcatgaaggt tgattttcct tcaccgtttg 716401 cgccgatcaa gccgacgtgc tcgcctttta acaggcggaa ggaaacgtta ttaaaaatgg 716461 cccggtcccc gaaaccgtgg cttaaatcct ttacagataa aatactcatg tttacacctc 716521 tatcgttatc aaacacgcac aatcggcgtg taatattcac ccttttgatt ataaaggagg 716581 attcggaatg ttgaaaggta taggaaagaa aaagaaaaat tgcgttccgg gcgaggtttt 716641 gagatactat ggaatagatt tcaggaattg aggagaacaa aatgacgcaa acttggccat 716701 ttttacataa tgcacaatca tttatacaag agaattggaa tgcttccggc tttcaaaagc 716761 caacccctgt tcaggagcag gcagcccagc tgatcatgga cggaaaggat gtcattgcag 716821 aatcgccgac aggcacaggg aagacgctgg cgtatgcgct gccggtcttg gagcggatca 716881 aaccagagca aaagcatccg caggcggtga ttttagcgcc ttcccgtgag ctggtcatgc 716941 agatttttca ggtgattcag gattggaaag cgggctcaga gctgcgcgcg gcttccttaa 717001 tcggcggggc gaatgtgaag aaacaggtcg aaaagctgaa gaaacatccg catatcatcg 717061 tcggcacgcc aggcagggtg tttgaactga ttaaagcgaa gaaactcaaa atgcatgaag 717121 tgaaaacgat cgtgcttgat gaaacggatc agctcgtcct gccggagcat cgcgaaacga 717181 tgaagcaaat cattaaaaca acattaagag accgccagct tctatgtttt tctgccacgc 717241 tcaaaaagga aacagaggac gtgctccgcg aattggcgca agagcctgag gtgttgaagg 717301 tgcagcgaag caaggcggag gcagggaaag tgaagcatca atacctgatt tgcgaccagc 717361 gcgacaaagt gaagctgctg caaaagctgt caaggcttga aggcatgcag gcactcgtat 717421 ttgtgagaga cattggcaac ctgagtgtat atgcggaaaa actggcatat caccacgttg 717481 aactcggcgt tttgcacagt gaagcgaaaa aaatggagcg agcgaaaatc attgccacat 717541 tcgaagacgg agagtttcct cttttattgg cgactgacat tgccgcacgc ggtttagata 717601 ttgaaaacct gccatacgtg attcatgctg atattccaga tgaagatggc tatgtccaca 717661 gatcaggacg aacaggccgg gccggaaaag aaggcaacgt gctgagcctt gtgacaaaat 717721 tggaggaatc taagctgaaa aaaatggcga agaagcttgg tgttgagctg agtgaagctg 717781 tgtatgcagg cggaaaactg aagacgaaat aaaaagaagg gcgaagagcc ctttttttgt 717841 tgtaaaataa tagaaaagat tttgcgcgga ggtgggaaaa tggcttcaat agacaggttt 717901 caagtaatgc aggagccaga gctgaaaatc cttgaacact ggtttgagaa tgaggatacc 717961 agacggagaa tggatgggat gctgctatta gatgagtggt atgcacgagt aaataaagat 718021 aaacacgata ctgtcatcat ggcgtatgat ggacagctgc cggcagggat ggtcgttatt 718081 gagttcggag aggagcggac atatattgga ttgatcgtca atcctttgta ccggcttaaa 718141 gggtatggaa aacagatact gcaaaagctg atgaccgaac ctgattttac tagcgtgcga 718201 gaatgggtgg catgcattga agaagacaat cgaatcagtt tagcttgctt tcaagcagca 718261 ggattcactt tagaagacac ggaacctgat gaagatggtt ttcttacgct gattcttcgc 718321 aactgatctc atcgaaacac aaaaggaggg caaaaagccc tcccgttttc atcttcattc 718381 agctcggatc actgaccttg atcagctgtt tccctttatt ttctccctta aataaaccga 718441 gaaacgcgtc aggaatgttt tcgaagcctt ctgtgatggt ttcctcgtaa tggagtttac 718501 cagccttcag ccattctgcc agctgttttg ctccctcaga aaaacgatcg gagtagtcgc 718561 ttacgataaa gccttgcatc agcgacttcg ttttaatgag ttttgattgg acacgagggc 718621 ccatgtcatc tgcttcgctt tctgcgttat aggaagaaat ggcgccgcac accggaatgc 718681 gggcaaattc attgagcaga ttcatcaccg cgtctgaaat cggtccgccg acattgtcaa 718741 aatacacatc gacaccgtca ggacaagcgt tttgaagcgc tttttggata tcatccgctg 718801 ttttgtaatt gatggcttcg tcaaactgaa gctcctgttt taaatagtcg attttttcat 718861 cagagcccgc gatgccgacg actcgcgcgc ctttgatttt ggcaatttgc ccgactgttg 718921 aaccgacggc tccggcagct cctgagacaa ccacggtttc gccttccttc gggcgtccga 718981 tgtccagcaa tccgaagtat gctgttaagc cggtcattcc caaaatgccg agataggccg 719041 aagcgggagc aaggcttgta tcaatttttc gcaaggcaga ctcgctcaca gcggaaaatt 719101 cctgccagct gagatttccg atgacgatat cgcctttttt cagatgattc ccgtctgaca 719161 caacttcagc gataacccct ccagaaagcg ctttatccaa ggcgaacggc tcaacatatg 719221 acttcgtatc ctgcatacgg ccgcgcatat aagggtcaac cgatacataa agcgttttga 719281 caagcacttc cccttgcttg ggttcaggaa ccggaatggt ttcaaagcga aagtcttcat 719341 gaacaggaat accttgtgga cgtcttgcta attgaatttg ctgctgagat gctgtcattt 719401 tcatcctcct atcacttggt tgacaccact gtaacatgga caggagagga aatacaaaag 719461 gtaagctggc atacaaaaaa ggttatagat gagcttatgc tttctacaag ctcttttgtt 719521 ttaaaagttc tctttagtca tttatcatta ttagaaaaca gaacagaaaa agagctcctg 719581 tacacctagc taagattggc tagtgtgtat gtcgattctt tttcatattc ttgcaagcat 719641 ctgcgagggg gagcttagtc gttcacattt tgctttcgca tcaatctgca atagcaaagt 719701 ctatgcgatt tttttacatc agcaaagatt tgttcaattt tttcctttta tgccgagttt 719761 ttctgaaaca gataattgat ggtactcaac cattttcttt tggtcaataa agtaatgttt 719821 acttattaat taaacacgcg aaaaagcaaa cgaaaacata attaaatttt atatatttat 719881 taaaagctta tatgtttatt tacctttttt ttgaattgta attgagaaaa tccatatatt 719941 gcggacacta ataaaagaat acctgctgaa acataaacta aacgaactcc aaggaaatct 720001 gaaatagccc ctatagccag aattgaaaac ataaaaatga actgtactaa agaagacctt 720061 gcagacatta tattaattcg agtttgctcg gttgttatgt tctgaataag tgtttcttgt 720121 gtaagatctc ttaatatata agccggcccc ataaagagaa ccaaaattag agctaagtat 720181 gaattactta taaaaccata tattaaagtt aaacttccat atgagacagc gccaattaac 720241 ataaaattaa ttaacttatt ttgaaatctc tccgacagct tatatattat aaatccccct 720301 atcatcgaac ctaaataata tgctccatta ataaatcccc accatgattc tcctttatgc 720361 aagacttcgt taacgaaagc taaagagaca gatcctatcc aaatcattcc tgcccatgac 720421 tcaattaaat ccataataat aattgttcta agtttctttt ggctaaataa ataccgccaa 720481 ccacttacta tactcttatt gggagaattt ttttcacgta tgacagaatt agcgtggcca 720541 tgtggtagac aaaataaaag agaaagaaga gatgtaaaca acaaaaagat agtaagtata 720601 atggtatatc cctcacctaa aaatgcaatt atgagaccac ctaaagacca gcctacaaat 720661 tgaaaagttt ggtccactgt agataataat ccatttgctt ttactcttct atcaggagag 720721 attatttccc ctataattgc actttttaaa ggtgagaacc atccattaaa aaaggaaata 720781 cagctaataa taataaagac taaaatgaga gtttgattag agtaagttct taataaagca 720841 tagaacaaac atattaataa cagcatttgt atcaattgag aaataattat tgtaagaggc 720901 agttttaatc gaattgttat taacggtaat atagcacttc caaaaatacg aaaaataata 720961 cttattaatg tcaccataga ggcgatggtt gtcgaattgg tcattttaaa caaaaacgaa 721021 atcactacca tagtatatag agaaaaacct aaatttgtag tggtctggct aaataaaata 721081 gaataataac ctttactcat atgtatcctc ccttggaata atttttctcg gtaaagagct 721141 taaacatatt taaacacctt aaaacaacaa aagtaaagaa aaaatttcct tgtaaactat 721201 ttacttttat tctatttatt gttattgttt atttaagttc tctgactatt ctatcaatat 721261 tcagggaacc acatatctta ttaaaggggg gaaaaccatg agaaaattaa gaaaaaactg 721321 gagaaaatcg attgttagcc cggttcttta tactaatgaa aaatggtaaa cacttaggga 721381 atagcattta atgctattcc ttatttcaac aaacaaatcg ggaggttatc gtaatttgac 721441 tctattaatg caagatcata aatcaattta caataaagat atagaaatat taattgaagt 721501 tgaagaactt attacttctg ttccagaaaa taaaaaaaat gattttaaga gtttaatcga 721561 taatagaatt atgactctac taaataaaat tcaacaccct gtagcagcgg aaaatgtgtt 721621 tgggatgtgt attgcttatc cgaatactta cataaggtat agattaattg atttcgttga 721681 aaaatgggta ccttatttct ctgctgtaga aactataatc aatctaaccc aggatccgga 721741 tgatttagtt tcttttaaag ctatggatgt ctgtgcaaat cataaaattg aagaatctgt 721801 agcatatttg tcttcgatta ttgatgatgt ccgggagagt ataagctacc ctaaaaaacc 721861 tgtgggatta ggggcccaaa aagtattaag tacattatta gatatattcg gtgttgaaaa 721921 acatgaagag ctagtaatgc taaaaaatta ttttgatcaa aatggtatac ttcctaataa 721981 ctttgacttt gaagaaaaaa ttcctcaaag tctaatagag gaattcgaaa aaacagaaga 722041 agatgggatg attttaattc cgggtggctt ttttgaattc ggtttaaatg aaaatgaaat 722101 tcctgacaaa acatttaatt ggaaagatgc tgttcctaga caaaaagtat ggttacctcc 722161 attttttatc gataagtatc ctgttacaaa taaagattat gatatcttta ccgagttcat 722221 agaggaaaat gggcatatat tctgtcatcc taatgaaccg cagaataaac aacatagaag 722281 aaatacatat tgggatgata ggtatttaga taatcatccc gttacaggta tagattttta 722341 tgatgcattt gcttacgcaa gatataaggg gaaagaattg ccaaccgagt ttcaatggga 722401 aaaagctgct cgaggcgaaa agggtaatgt ctggccttgg ggagataaat ttgatcctgc 722461 aaaggttcaa tatgctggaa gtctttataa tgaacccatt acttctttaa agtcctggag 722521 agaaaattta ttaaaagctc atgctgataa agaattaaat catttaacaa gtgatatttt 722581 tgaacaaaat ggtgaaagtc cctatggagt atgcggtatg atcggcggaa catgggagtg 722641 gactagaagt gagcttaaaa caaagagagc tttccaccct atttttgaga atgtaccatt 722701 taatagtgtt aactcatttg ccgttcttaa aggaggatca ttcttctctc atccaggctt 722761 aatgttccct tcttttagag caaaagatat tcctttctgt cgacacaatg aaatggggat 722821 tagatgcgta aagaatattc cagtatataa aattagagaa tcaattaatg ggccaattac 722881 taataaagca atttattaat cattctaggt tagagacttg ataaaagtat actaacattg 722941 tgtagtaatg ttcagcttgt agaaaaaaca atgttttttc tacaagattt tattttaaat 723001 gcttttcaaa attatcaggg attgagaatc agaaaaagag ccattaagct cgatcttagc 723061 taggtattac gatcttctgt atattattgt gagaaatata gaagattcag ttagttagca 723121 tttcgatttt aagctgagcc tgcaatagca aagcatctgt tttgattatt ctttttctga 723181 tacataagct aattttgtcg cttttctttt ttgtcttttc acgcatttcg aggatgactt 723241 actataattc tttcagcttt tctatgtgtt aagattcgaa tagatgaaat aactttaaca 723301 agttggtcaa taagaacaga tttaacttta tgttaaaaga gtatctcgta tagaacataa 723361 gaagaatgac gagtttttta agattatcat caattatgtg agaataaaat attataaggg 723421 aaaatgaagg ctgtcacgtt tctcgacagc cctagggaat tcctctcctt ttcatttcgc 723481 ccgtaatttc gggcacagtc ccgtcggcag gcacattggc ttctggtcga tcgggcttct 723541 catgatgcag cattccaagc cgaagacttc acggaaaaat ggctgggtga acacatcttc 723601 cggtgttccg gcgttgtata tttttccgtc cagcacactg atcagatagt cagcatattg 723661 agcggcttgg tttaaatcat ggagcaccat gacaacggtg cggccatggt cgcggttcag 723721 ctttttcagc agttcaagca cttcaatctg atgtgagatg tctaaatacg tggtcggctc 723781 atcaagcaaa agcaaatcag tgccttgcgc aagtgccatg gaaatccagg ctctttgtct 723841 ttggccgcct gagagggcat caagtgtccg atccttcagt tcaatcatgc ccgttgcttc 723901 cagcgcccac tctaccatgt catgatcctc ttgggtatgc ttggataaca gctttttgtg 723961 aggatgtctg ccaaaatagc ataattcctc taccgtcaat ccttcaggag cctgaggaga 724021 ttgtggaaga atggccagtt tttttgcgac ttcttttgat ggctggcggt ggatgtcttt 724081 tccttctagt agcactgtac cgctttttgg ggccatcagc ctggcgagcg atttgaggat 724141 tgttgattta ccgcagccat tagcgccgat gagcgcagtg atttttcctt cttctatctt 724201 taagtcgact ccgtcaataa tcactgtact gtcatatgaa agagtgagct ggtctgcagc 724261 cagttttccc atggtatcct ctccctactg tttcctcgct tcgaatttca ataaatataa 724321 gaaataaggc gcgccgatca cggctgtcag tattccggca ggtatttcaa ccggaggcat 724381 gatgccgcgc cctaacgtat ctgcaattaa taatataata gcaccaatca atgccgatgc 724441 aggcagtaaa tatttagctt tttctccggt aagccgtctg gcgatatgcg gagcaagcaa 724501 gccgataaaa ccgattgagc cgacgacggc tacacagctt cccgccagcg ccaccgcggt 724561 gaaaatcagg atgaatctca gccggtttgc gttttctccg agaccctgtg caagctcatc 724621 cccgagtgac ataagatcca gcttcggtat gagtatgcag acgatcggaa aaagaatcaa 724681 aagccatggc gcaagcagct tgacttcttc ccagtttctt ccccagaggc ttcctgtcag 724741 ccaaatgagt gcagcattca cgtcgcctgg aaacttgacc atcatatatt gcattccggc 724801 gtggcagacc gcgcctaaag caatgcctga taaagccagt gaagagggct gaatgctctt 724861 ttttcgggct atcattaata atagtacagc aataatggcg gctccggcaa atgcggagaa 724921 cggaagcacg tataccggcg actcaggaaa gatgagaatc acagccatcg ccgcaagtcc 724981 ggagcctttt gaaatgccga caacgtccgg ggaagcgagc ggatttcgga tcacaccctg 725041 taaaatcgct ccggcagcgg caagtccagc acctgccaaa atcgctaata taatgcgggg 725101 aaggcgatat tgctggatga taaattcaaa ggaatgatcc agtcccagca gattcgtcac 725161 taccgcatca ggtgaaatgt ataatgcacc gattccaatg ctgatgacgg acagaacgat 725221 taaaatcacg gccaatatga gtatcgccag taaggggcgt ttttgttttc tggttgtttt 725281 cttcatttca ggtttcgccc tttccttgcc aaatataaga aaaacggcgt tccgataatc 725341 gcggtgacaa tgccgaccgg tgattcataa ggaaatgcaa tccatctggc cagaacatct 725401 gcgtacacca gcaaaatggc accgaacagt gccgaaaacg gaagcacgta ttgataatgt 725461 tctccgatca gcttgcggac aatatgcggg acgagcagcc cgacaaagcc aatcggcccg 725521 gcgacggcta cggaagcgcc ggaaagaatt aaaataatca aactgatcag aatcctgatg 725581 ccgttcatat tttgtccaag cccttttgct gtttcgtctc cgagaccgag aacagaaaca 725641 gaaccggaaa atacgagggc aagcccgatg ccaatgacag aaaaaggagc gatggttatg 725701 acgtcctgcc agttgctgcc gtcgattgcg cctgtcatcc agtacagaac atcctcacct 725761 gactcattta aaataatgat ggcctgtgtc atagaggaga ggaacaagtg cacggccatt 725821 cctgacagcg ccagcttgac aggcgtcatt ccgccggatg aggcaatcat atacacaatc 725881 gcgccgcctg ctgccgcacc cgcaaaagcg aatataacag atgaataggg cgatgccggc 725941 agaatgacga gagaagcaac aacaaaaagc gatgcacccg cattcacacc gaaaatttgg 726001 ggtgaagcca gaggatttct ggtcatagcc tgcatcagcg cccctgctac agctaggctg 726061 gcgccgacaa aaacgccgat taatgtgcgg ggaaggcgaa gagtagagat gatgagctgt 726121 tcctttgaac cgtcccatac aaaaagatat ttcaatgaat ctatgatgct gatgtctgag 726181 gctcctactg aaagattcag cccaagccca aatataaaaa taatcagtgc aatgataaac 726241 atcatcagtc ttgatgatga gcgccgtttg gctgaatgat acaacagtct cacttcctta 726301 ctgcgtctgg ttgcaaaaac gaagaagcaa ggattcccct cgcttctcat ttgtcctatt 726361 tattatacac ttttttaagc acatctttgg cgcttgtttc actagacttg atgcctctga 726421 atcttgtcca agtgtcacgg tccgcatcat agacttgtcc atttttcacc gctttgagat 726481 ttttccagag cgggttcgtt ttccactcat ctacaatggt tttgccttcg ttggctgaga 726541 tgaacaaaat atcaggatcg attttgctca attgctcaag gctgacctct tgataggcgt 726601 tatctgactt cacagcgtgt gtaaagccta gcattttaaa gatttctccg tcataggatg 726661 atgatgtatg aagctggaag gaatccgctc ttgcaacgcc gagaacgatg ttgcggtttt 726721 catctttcgg aagttcggct tttagatcgt tgatgacttt tttgtgctcg gcaagctttt 726781 cttttccttc atcttcttta tttaatgctt tagcaatggt cgtaaagctg tcgatcgttt 726841 cgtcatatgt cgcttcacgg ctttttaatt caatcgtcgg ggcgattttt ttcagctgtt 726901 tataaatgtt tttatggcgc tcagcgtcag cgatgattaa atcaggcttc aaggaactga 726961 tgacctcaag attgggttcg ctgcgtgtgc ctacagatgt gtaatcaatg gagctgccga 727021 caagcttttt aatcatatct tttttgttgt catctgcgat gcccaccggc gtaatgccga 727081 gattgtgaac ggcatccaag aatgaaagct caagcacaac cacccgctta ggtgtgccgc 727141 ttactgtcgt ttttccttct tcgtcatgga tcactctgga atccttagac tcgcttttgc 727201 cgcttccgtt gttattctgg cttgatgaac agccggatac aatgaggcag gcgagcaata 727261 aaacactcat gatggcaatc aacttgttag aataggtgcg catgtcattc ttcctttttt 727321 cagatttagt aatgagaatc attatcacat gtaacactat aatagcatgg cttatcatgt 727381 caatattttt ttagtaaaga aagctgcgtt tttactgctt tctcatgaaa gcatcatcag 727441 acacaaataa gtggtatgca gcgttaccgt gtcttcgaga caaaaacgca tgggcgttgg 727501 ctttagaggt ttcgaacata tcagcagtga cataaggaag gagagtgctg agataaccgg 727561 acaatttctt ttctatttca tctgttagtg caaattcaat gtcgccgata ttcatgataa 727621 tcgagaaaac aaagtcgata tcgatatgaa aatgttcctc ggcaaaaacc gcaagctcgt 727681 gaattcctgg tgaacatccg gcacgcttat ggaaaatctg tttgactaaa tcactcacaa 727741 tccaagcatt gtattgctgt tctggtgaaa agtattgcat tagacatacc tcctgctcgt 727801 acggataaag gcagcgtttc atggtcgtgt gctccgtgca gcggcttctc cttaattttg 727861 atttttctga aaataggtcc cgttcctatc actttaccat ggacggaaaa caaatagcta 727921 ctaccattcc tcctgttttt ctcttcaatg ttctggaatc tgtttcaggt acagacgatc 727981 gggtatgaaa gaaatataga aaacatgaag gaggaatatc gacatgaaac cagttgtaaa 728041 agagtataca aatgacgaac agctcatgaa agatgtagag gaattgcaga aaatgggtgt 728101 tgcgaaagag gatgtatacg tcttagctca cgacgatgac agaacggaac gcctggctga 728161 caacacgaac gccaacacga tcggagccaa agaaacaggt ttcaagcacg cggtgggaaa 728221 tatcttcaat aaaaaaggag acgagctccg caataaaatt cacgaaatcg gtttttctga 728281 agatgaagcc gctcaatttg aaaaacgctt agatgaagga aaagtgcttc tctttgtgac 728341 agataacgaa aaagtgaaag cttgggcata aagcaaggaa aaaaccaaaa ggccaatgtc 728401 ggccttttgg tttttttgcg gtctttgcgg tgggattttg cagaatgccg caataggata 728461 gcggaacatt ttcggttctg aatgtccctc aatttgctat tatatttttg tgataaattg 728521 gaataaaatc tcacaaaata gaaaatgggg gtacatagtg gatgaaaaaa gtgatgttag 728581 ctacggcttt gtttttagga ttgactccag ctggcgcgaa cgcagctgat ttaggccacc 728641 agacgttggg atccaatgat ggctggggcg cgtactcgac cggcacgaca ggcggatcaa 728701 aagcatcctc ctcaaatgtg tataccgtca gcaacagaaa ccagcttgtc tcggcattag 728761 ggaaggaaac gaacacaacg ccaaaaatca tttatatcaa gggaacgatt gacatgaacg 728821 tggatgacaa tctgaagccg cttggcctaa atgactataa agatccggag tatgatttgg 728881 acaaatattt gaaagcctat gatcctagca catggggcaa aaaagagccg tcgggaacac 728941 aagaagaagc gagagcacgc tctcagaaaa accaaaaagc acgggtcatg gtggatatcc 729001 ctgcaaacac gacgatcgtc ggttcaggga ctaacgctaa agtcgtggga ggaaacttcc 729061 aaatcaagag tgataacgtc attattcgca acattgaatt ccaggatgcc tatgactatt 729121 ttccgcaatg ggatccgact gacggaagct cagggaactg gaactcacaa tacgacaaca 729181 tcacgataaa cggcggcaca cacatctgga ttgatcactg tacatttaat gacggttcgc 729241 gtccggacag cacatcaccg aaatattatg gaagaaaata tcagcaccat gacggccaaa 729301 cggatgcttc caacggtgct aactatatca cgatgtccta caactattat cacgatcatg 729361 ataaaagctc cattttcgga tcaagtgaca gcaaaacctc cgatgacggc aaattaaaaa 729421 ttacgctgca tcataaccgc tataaaaata ttgtccagcg cgcgccgaga gtccgcttcg 729481 ggcaagtgca cgtatacaac aactattatg aaggaagcac aagctcttca agttatcctt 729541 ttagctatgc atggggaatc ggaaagtcat ctaaaatcta tgcccaaaac aatgtcattg 729601 acgtaccggg actgtcagct gctaaaacga tcagcgtatt cagcggggga acggctttat 729661 atgactccgg cacgttgctg aacggcacac agatcaacgc atcggctgca aacgggctga 729721 gctcttctgt cggctggacg ccgtctctgc atggatcgat tgatgcttct gctaatgtga 729781 aatcaaatgt tataaatcaa gcgggtgcgg gtaaattaaa ttaagaaagt gaaaaacaca 729841 aagggtgcta acctttgtgt tttttaatta attaaaatgt ttattaactt agttaaggag 729901 tagaatggaa aaggggatcg gaaaacaagt atataggagg agacctattt atggcttcag 729961 aaaaagacgc aggaaaacag tcagcagtaa agcttgttcc attgcttatt actgtcgctg 730021 tgggactaat catctggttt attcccgctc cgtccggact tgaacctaaa gcttggcatt 730081 tgtttgcgat ttttgtcgca acaattatcg gctttatctc caagcccttg ccaatgggtg 730141 caattgcaat ttttgcattg gcggttactg cactaactgg aacactatca attgaggata 730201 cattaagcgg attcgggaat aagaccattt ggcttatcgt tatcgcattc tttatttccc 730261 ggggatttat caaaaccggt ctcggtgcga gaatttcgta tgtattcgtt cagaaattcg 730321 gaaaaaaaac ccttggactt tcttattcac tgctattcag tgatttaata ctttcacctg 730381 ctattccaag taatacggcg cgtgcaggag gcattatatt tcctattatc agatcattat 730441 ccgaaacatt cggatcaagc ccggcaaatg gaacagagag aaaaatcggt gcattcttat 730501 taaaaaccgg ttttcagggg aatctgatca catctgctat gttcctgaca gcgatggcgg 730561 cgaacccgct gattgccaag ctggcccatg atgtcgcagg ggtggactta acatggacaa 730621 gctgggcaat tgccgcgatt gtaccgggac ttgtaagctt aatcatcacg ccgcttgtga 730681 tttacaaact gtatccgccg gaaatcaaag aaacaccgga tgcggcgaaa atcgcaacag 730741 aaaaactgaa agaaatggga ccgttcaaaa aatcggagct ttccatggtt atcgtgtttc 730801 ttttggtgct tgtgctgtgg atttttggcg gcagcttcaa catcgacgct accacaaccg 730861 cattgatcgg tttggccgtt ctcttattat cacaagttct gacttgggat gatatcaaga 730921 aagaacaggg cgcttgggat acgctcactt ggtttgcggc gcttgtcatg ctcgccaact 730981 tcttgaatga attaggcatg gtgtcttggt tcagtaatgc catgaaatca tccgtatcag 731041 ggttctcttg gattgtggca ttcatcattt taattgttgt gtattattac tctcactatt 731101 tctttgcaag tgcgacagcc cacatcagtg cgatgtattc agcatttttg gctgtcgtcg 731161 tggcagcggg cgcaccgccg cttttagcag cgctgagcct cgcgttcatc agcaacctgt 731221 tcgggtcaac gactcactac ggttctggag cggctccggt cttcttcgga gcaggctaca 731281 tcccgcaagg caaatggtgg tccatcggat ttatcctgtc gattgttcat atcatcgtat 731341 ggcttgtgat cggcggatta tggtggaaag tactaggaat atggtagaaa gaaaaaggca 731401 gacgcggtct gccttttttt attttcactc cttcgtaaga aaatggattt tgaaaaatga 731461 gaaaattccc tgtgaaaaat ggtatgatct aggtagaaag gacggctggt gctgtggtga 731521 aaaagcggtt ccatttttcc ctgcaaacaa aaataatggg gctgattgcg gctctgctgg 731581 tctttgtcat tggtgtgctg accattacgt tagccgttca gcatacacag ggagaacgga 731641 gacaggcaga gcagctggcg gttcaaacgg cgagaaccat ttcctatatg ccgccggtta 731701 aagagctcat tgagagaaaa gacggacatg cggctcagac gcaagaggtc attgaacaaa 731761 tgaaagaaca gactggtgcg tttgccattt atgttttgaa cgaaaaagga gacattcgca 731821 gcgcctctgg aaaaagcgga ttaaagaaac tggagcgcag cagagaaatt ttgtttggcg 731881 gttcgcatgt ttctgaaaca aaagcggatg gacgaagagt gatcagaggg agcgcgccga 731941 ttataaaaga acagaaggga tacagccaag tgatcggcag cgtgtctgtt gattttctgc 732001 aaacggagac agagcaaagc atcaaaaagc atttgagaaa tttgagtgtg attgctgtgc 732061 ttgtactgct gctcggattt attggcgccg ccgtgctggc gaaaagcatc agaaaggata 732121 cgctcgggct tgaaccgcat gagatcgcgg ctctatatcg tgagaggaac gcaatgcttt 732181 tcgcgattcg agaagggatt attgccacca atcgtgaagg cgtcgtcacc atgatgaacg 732241 tatcggcggc cgagatgctg aagctgcccg agcctgtgat ccatcttcct atagatgacg 732301 tcatgccggg agcagggctg atgtctgtgc ttgaaaaagg agaaatgctg ccgaaccagg 732361 aagtaagcgt caacgatcaa gtgtttatta tcaatacgaa agtgatgaat caaggcgggc 732421 aggcgtatgg gattgtcgtc agcttcaggg agaaaacaga gctgaagaag ctgatcgaca 732481 cattgacaga ggttcgcaaa tattcagagg atctcagggc gcagactcat gaattttcaa 732541 ataagcttta tgcgatttta gggctgcttg agcttgggga gtatgatgaa gccattgatc 732601 tgattaaaga ggaatatgcg atacaaaatg aacagcatga tcttttattc cataacatcc 732661 attcgcagca ggtgcaggcc attttgttag ggaaaataag caaggcatcg gaaaagaagg 732721 tcaagctggt gattgatgag aacagctcac tcgcgcctct tcctgcgcat atcggcttgt 732781 cccatcttat tacgattatt ggcaatttaa ttgataacgc tttcgaagct gtagcggagc 732841 aaagcgtgaa ggaagttttg ttttttatca cggatatggg ccatgacatt gtcattgaag 732901 tatcagacac agggcccggt gtgccgccag agaaaataga agctgtgttt gagagaggct 732961 attcttcaaa ggggatgagg agaggctacg gtctggccaa tgtgaaagac tcagtgcgtg 733021 aactgggcgg ctggatcgaa ctggcgaatc aaaaaactgg cggggcggta ttcactgtat 733081 ttataccgaa ggagaaacaa agggggaatc catttgattc acatcgcgat tgcggaggat 733141 gattttcgag ttgcgcaaat ccatgagaga ttgattaaac agcttgatgg attcaagatt 733201 atcggcaagg cggctaacgc aaaagagaca ttggcgcttt tgaaggaaca caaggctgat 733261 ttgcttctgc tggatattta tatgccggac gagcttggga ccgcgttgat tcctgatata 733321 cgaagccgat ttcctgaagt ggacattatg attatcacag cggcaacaga aacccgtcat 733381 ttgcaggaag cgctaagggc gggaattgcc cactatttga tcaaacccgt aacagctgac 733441 aagttcaggc aggtgctgct tcagtataaa gaaaaaagga agctgctcat gtctcagccg 733501 gaggtcagcc aatccatgat cgaccatatt tttgggaacg gtgtgaagac agctttgccg 733561 gcagaggatt tgccgactgg cattaattcg attacactgc gaaaaattaa ggaagcgctt 733621 cagactgcgt cagaaggatt gacagcggag gaacttgggg aaaaaatggg ggcgtcacga 733681 acaactgccc gccgttatgc cgagtacctt gtgtcaaagg aagaagcaag agccgagctt 733741 gaatacggga ttatcggcag gccggagaga aaatattatt tggcggcgga ttagatatga 733801 aaaaatctat aatcctattg aatattctat tgatctttat gcagggtgat atcaggcagg 733861 cggctgcgcc gcgcctgccg gacgggccga tagaaattgt cgtccctgcc gaaccttctg 733921 gcggctggga tgtcacagcg caggcgatcc aatcagtttt gaggcagaag cagatcgtga 733981 aggatgatgt tcatatcgtc tataaatccg gcggcggggg agagaaaggc tggaaatatg 734041 tcaacaaaag cagcaaacaa accatcagca tgacgtccag cctaatattg agcaatgatc 734101 ttctcgggca aagcaaatta aaaatgtccg attttacgcc gctcgccatt ctctccaagg 734161 aatggcagac ggttgcattg ccaaaaggat cagcgttaac aaatggcaag gatgtgctga 734221 atgagatcaa catgcatccc ggcaaggtga gaatcggctt tgccccgggg tttggcaatg 734281 atgatcagct ctcgttcgtc agagcggcag atatgtacgg cattgacccg tttgacattc 734341 aattctcaca gtatgacagc agcgaacagc tcattcaggc gctgatcaga catgagatag 734401 aagcggcttc catgacactt tctgaagcga aaccatatga acgaaacggc gatatcacgt 734461 tagccgctgt aacgtctgat aaaagacttc ccggttttcc aaatgtaccg acgtggaagg 734521 agcagggaat cccgtttgtt ttttctcatt ggagagggat tttgggcccg aaaaatatgt 734581 ctgaggaaga gatttcttac tgggatcaag cgctaaagaa ggtcacctcc tcacctgaat 734641 ggaagcggaa aataaacgaa caggactggg aaagctttta tttaaacagc agggaaacga 734701 aacggttttt agaagagcaa tctgcttttt atcaaagcat catgacagga aattaaaatc 734761 ccgacatccc gggatttttt tcatgccgaa aattgatcaa aaagaacaaa acggttttaa 734821 aaaattaaaa atacaaaaaa accaaattat ttacttgcgg ttggttttcc catacgatgg 734881 caaaaaggca agacaaaaag gggagtaagg gagaaaaaaa tgtaagcgga ttcatttaag 734941 ggggaatgga tgtgttagca atcttaggct ttctcatgat gcttgtgttt atggcattga 735001 tcatgacaaa acggctttct gttttaacag cattagtttt gacgccgatt gtgtttgcgc 735061 ttatcgccgg atttggattt actgaagttg gggacatgat gatttcgggg attcagcaag 735121 tcgcgccgac tgcggtcatg attatgtttg cgatcttata ttttggaatt atgattgata 735181 caggcctgtt tgatccaatg gttggcaaaa ttttaagcat ggtcaaagga gaccctttaa 735241 aaattgttgt cgggacagcg gttcttacaa tgctcgtcgc cttggacgga gatggctcga 735301 caacgtacat gattacgaca agcgccatgc ttccgctcta tttgctgcta ggcatccggc 735361 caattatctt ggcaggaatc gcgggagtcg gcatgggaat catgaacacg attccatggg 735421 gaggtgcgac gccgagggcg gcgagtgcgc tgggggttga tccagctgag cttacagggc 735481 cgatgattcc tgtcattgca agcgggatgc tttgtatggt ggcagttgcg tatgtgcttg 735541 gaaaagcgga acgaaagcgc cttggtgtga ttgaactgaa acagccagcc aatgccaatg 735601 aaccggctgc tgcggttgaa gatgagtgga agcggccgaa gctttggtgg ttcaatttat 735661 tgttaacgct ttctttaata ggatgtttag tatcgggtaa agtcagttta accgtactgt 735721 ttgtcattgc gttttgtatt gcgctgattg tgaattatcc caatctcgag catcagagac 735781 agcgcatcgc ggcgcattcc agcaacgtgc tggctatcgg ttcaatgatt tttgctgcgg 735841 gggtgttcac ggggattttg acaggcacga aaatggttga tgaaatggcg atctcgctcg 735901 tgtccatgat accggaacaa atgggcggat tgatcccggc gattgttgcc ttaacaagcg 735961 gcattttcac atttttgatg ccgaatgacg cgtatttcta cggggtgctg ccgattttat 736021 cagaaacagc tgtcgcatac ggtgtggata aagtggaaat tgccagagcc tctattatcg 736081 gccagccgat tcatatgctg agtccgcttg tgccatccac tcatttgctt gtcggactcg 736141 tcggagtttc tattgatgac catcaaaaat tcgcattgaa atgggcggtt ctcgcagtga 736201 tcgtcatgac ggctatcgct ctattgatcg gtgcgatctc tatttccgta tgataattca 736261 ggcgtaatga cacacactaa cggcatacaa cattccggag gtgtcattat gagtgatcct 736321 tatatgccgc tgacttcagt cagaagcgga gcggggttcg aagcggcaaa aggggtgcac 736381 ggcctgactg tgcaaattgc gaatgtctat tttattcagc tgccttctga acctcactca 736441 tttgttttaa ttgatgccgg catgccccaa tcagccggcg tgattgtcaa tgaagccaaa 736501 caaagattcg gtgaagggtt tcagctgaag gcgattatcc tcacacacgg gcactttgac 736561 catattgggg caatcgaaga gatccttgag cattgggatg tgcctgttta tatccattct 736621 cgggaaatgc cttatgtaac aggtaaagag gattatcctc cggctcgtcc tgacagcaag 736681 agcgggctgg tcgctaagct gtcgccgctg tttccgcggc actctatcga tatttcctca 736741 catgtccagg cactgccgga agacggttca gttccttttc ttgacgagtg gatgtggatc 736801 gcgacaccag gacacacgcc gggccatatt tcgttattcc gcgatgacgg ccgcgtgctt 736861 gtggcaggtg atgctgttat tacagtggaa caggagaaaa tggctgacgt cttgatacaa 736921 aaacaggagc ttcacgggcc gccggcttat ttcacgcctg acacagagac ggccgctgag 736981 tccattctaa agctggccgg tcttgaaccg gaagcgttat tgaccgggca cggcataccg 737041 atgaccggca aaaactttcg aagtgactta actgaattgg caaatcggtt atcgtctatt 737101 tgacacccgc accacgcggg tgttttttat tgttttccag gaagttgcag aaaaatcatt 737161 tgtcttgccg cttaaaaacg atacaatgaa aagcatgaag tgatgtgaag gggagagttt 737221 gttggaagaa aaagaaatac tctggaacga agcgaaagcg tttattgccg catgctatca 737281 ggaattggga aaggaggagg aagtgaaaga ccgtctcgcg gacattaaaa gtgaaattga 737341 cctgaccgga agctatgtac atacgaagga agagctggag cacggagcga aaatggcttg 737401 gagaaacagc aaccgctgca tcggcagatt gttctggaat tcgctgaatg ttatcgacag 737461 acgagacgtc cggacgaagg aggaagtgcg tgatgccctc tttcaccata ttgaaaccgc 737521 caccaataac gggaaaatca gaccgaccat tacgattttc cctccggaag agaagggtga 737581 aaagcaagtc gagatctgga atcatcagct gatccggtac gctggatatg agtcagacgg 737641 agaaagaatc ggcgacccgg cttcctgttc cctgacagca gcctgcgaag agctcggctg 737701 gcgcggagag cgaacggatt ttgacctgct gccgctcatt tttcgcatga aaggggacga 737761 gcagcctgtc tggtatgagc tgccgcgttc acttgtgatt gaggttccaa tcacacatcc 737821 ggacatcgag gcgttttctg atttggagct gaagtggtac ggcgtgccta ttatttctga 737881 tatgaagctt gaggtcgggg gcattcatta taatgccgcg ccatttaacg gctggtatat 737941 gggcacggag atcggagcga gaaacctcgc agatgaaaag cggtacgaca agctcaaaaa 738001 agtagcgtcc gtgatcggca tcgccgctga ttacaatacg gatttatgga aggatcaagc 738061 gctagttgaa ttgaataaag ctgtgctgca ctcgtataaa aagcagggtg tcagcatcgt 738121 tgaccatcat acagcggcaa gccagtttaa acggtttgaa gaacaggagg aagaagcggg 738181 cagaaagctg acgggggact ggacgtggct gattccgcca atttcacccg ctgccactca 738241 tatcttccac cgctcctatg ataactcaat cgttaagccg aactattttt atcaagataa 738301 gccttatgag taaacaatag aaaatcgatg atggccttca aggctgcggg attcagtcac 738361 agagatgtcg gtaacctttg agaaagggct tccgttcttt acagcctcaa caaacgattg 738421 cagggcgttt tccggaccct ctgccaaaat ctcgacacgc ccgtcatcac ggtttttgac 738481 ccagccggcc agttttcgct tatcagcttc catttgaaca aaatagcgaa agcccacacc 738541 ttgaacccgg ccgtctacaa tgattcggta ttgaagcatg taaaaaccac cttttctttt 738601 tatgataatc aatcatttta caacctgtaa aggggatgtg tttgtatgaa acaagagcgc 738661 tattcagttc tttctcttaa tctgggaaaa ccgcagacgc ttgaatatga cggaaagaaa 738721 atcgaaaccg gcatcatgaa gcggccggct aaatcagccg tcatgctgta tcgggagaat 738781 tttgaaggag acggacaggc ggacctcgtc aaccacggcg gacctgataa ggctgtctgt 738841 gtctacccgg cggagcatta tccgttttgg gaagagttcc tctcaagacc gctgtcaaat 738901 gccgcatttg gagaaaatct gacggtcgcg ggcctgactg aggagaatgt ttgcatcggg 738961 gatgtgttca gacttgatga agctgttgtt caggtcagcc agccgcgcca gccgtgtgta 739021 aagctggcga aaaagtttgg tgtaaaagaa atggtgctga aggtccagca aaccggctat 739081 acagggtttt attttcgcgt gctggaggag ggcagggtgt ctcccggcgc gaaccttgaa 739141 ttgctgtcca gaggagagaa aggcatatcc gtccagttcg cgaaccgcat caactaccat 739201 gatgcaaaaa atctcaccgc cattgaacgg attttaagtg aggctgcact atcggaaagc 739261 tggagagcgt cctttatgaa aaaaaaggac aggctgctgc cggttgaata gaaaaaagcc 739321 gcgcatatca acgtgcgcgg ctttgccata tttaagattg ttttttcttt gattcaagca 739381 ggttggcaag aaaataggtt ttatagcttt gaagctttct tccttcatgg tgcgtgatcc 739441 cctgcttttt tagttctgcc acataccagc ctttactgcc gtaatgcatg tcagaaaact 739501 cctttcccta tctgatttcg aaacgattgg cattgtaaca tctataaaaa gatgctgaaa 739561 agagatgcgg ggaaaactga gcctttcgca ctagatgtac gaatgttctt ctgaatgtat 739621 atgcggagca aaagccgaat atgatttaat ggccggttag tttgatcatg acaacgccaa 739681 atgtcataat ggcgaaaaca atgccgatat atgtgagcat cccgtttttt ttcttaacgc 739741 cgtaaacggt cataatgatg ccttcaatga aaaaaatgat gccgaaaata ataaaccaca 739801 tgcagataaa ggctcctttc acagacataa tagtagtgta gcatatctga aagagccggg 739861 ctgtgacaat atcaagaaag ccgggcgcat atcgcccggc tcatgtttta ttgtttatca 739921 accaatttga ccagaagctg tgccaaatgt tctttctcat cttcgtctgc aacgctccaa 739981 agctcttgca gcagcatttc ttcaccgttt tgcggctctt catgctttgc gaggtagtct 740041 cccaggatcg cagcgctttt tacaagcttg ccgtcatcca atcccagctt tttgcctcgg 740101 ttgacttgtt ttttcaggta gcctttaaat tcctcaaagt cttttaaaat gtcttctttt 740161 attgtgccat gcatcgcgtt catttcgttt tcaatttgga ttttttcttg atctctgttc 740221 attgcaagac ctcctcgtac agaataatga tgctttacct gcaattggag gaggttaaac 740281 ctgccggaag cccggaatgt gttttacagt ttcgtcagga taatcggttc atcttttgtg 740341 atgacgatcg tgtgttcaac ttgggcaacc atgcttttat ccggcgtctt gaacgtccag 740401 ccgtctccag cttcaacaat cgtttctgct ttcgttgaaa taaacggttc aagcgcgatg 740461 actgtgccat ttttgaacag cgcattatca aacggatcat aatagttcat gatgtggttc 740521 ggcgcttcat gcaggcttcg gccgattccg tggccggtca gggttttgat gacggtaaag 740581 ccttgagagc gtgcttcatg ataaacggct cttccgatct ggttttggcg cttgcccgct 740641 tttgcctgct gaagcccctt ttgaaaagcg ttttccgcgc attggcaaag cttatgaagg 740701 cgttcttctc cttcaccgag cacaaatgag atgcctgtgt cggaatagaa gccgccaaat 740761 tcagcggaga tgtcgatgtt gacaaggtcc cctgctttta aaattttgga tgtgcttggt 740821 atgccgtgag ccacttcatc atttacgctg atacatgtca cacctggaaa atcgtattcc 740881 ttctcaggag ctgaaacggc gccgtgctca tcaagcacag cttttccgat aaggtcaagg 740941 tcttttgtgc tcatgccggg ctctgccttc cgcttcattt cttcacgcgc aagcgcgacg 741001 attcttccga tttttttcag gccttctaat tcttgatcgt ttgttacaat catctgtcat 741061 tcccgctttc tttttaaata atctagatta agcttaccac aactgtctta aaaataggaa 741121 acacacggac ctgggaaaaa agaaataccc ccgggaaaat tggtatagat cactagatat 741181 cttatatggt atatttgaaa aaaaagggta tgagggggat gggtatgctt tcatttttac 741241 aaaaactcgg gaagtcattt atgctcccga ttgcggttct gcctgcggtt ggaattatcc 741301 ttgcgcttgg cagagaggat gtatttaata tcccgtttgt ctatcaggcg gggacggcgg 741361 tttttgatca tctgccgctt atttttgcga tcggtattgc catcggcatt tcaaaagaca 741421 gcaatggggc agcgggttta tcaggggcga tatcgtatct gatgcttgac gcggcaacaa 741481 agacaattga taaaacaaat aacatggcgg tgtttggggg aattattgcc ggtttaattg 741541 ccggttacac ctataaccgc ttcaaggata ccaagctgcc tgaatatctc gggttcttca 741601 gtggcagacg gcttgtgccg attttaacag ccattattac gatcatttta gcgggcatat 741661 tcggagtggt ctggccgccg attcaatcgt gtatcaactc gtttggagag tggatgctcg 741721 ggctcggcgg catcggggca ggcatattcg gcctattcaa caggctgtta attccgcttg 741781 gccttcacca tgtgctgaac aatattttct ggttccaatt cggagaatat aacggagtga 741841 caggggattt ggcgcgcttt ttcgcgaaag atccgactgc gggcacatat atgaccggat 741901 ttttcccaat catgatgttc ggtcttccgg cggcgtgtct ggctatggtt gtgactgcga 741961 agccgtctaa acggaaagcg acggctggaa tgatgattgg atttgcttta acggcgttta 742021 tcacagggat tacggagccg attgagtttg catttatgtt tttatctccg cttttatacg 742081 ctgttcacgc ggtcttaacc gggttatctt tatttatcgt caactggctc ggcatccgct 742141 caggcttctc tttttcagcc ggagctatcg attatgtgct cagctatgga atcgcggaaa 742201 aaccgctgct tctgcttttg gtaggtatat gctatgcggc agtatacttt atcgtgtttt 742261 atgtactgat taaggctttg aatttaaaaa cgcctggacg ggaagacgat gatgtggatg 742321 aagtgctgga tgaaaatact gttcaggatg taaatgaaaa catcatgctg aaagggctcg 742381 gcggaaaaga aaaccttcaa accattgatc attgcgccac aaggctgcga ctgactgtga 742441 aggataccgc tttggtggat gaagcactgc taaagaaagc aggcgcaaaa ggggttgtca 742501 aatcgggcgg gcaatcggtt caagtcatta ttggcccgaa tgtggaattt gcagctgagg 742561 aattgagggc tgctgtcaaa taaaaaagcg gagagggcaa cctctccgct ttttcttatt 742621 tatcttcgtt atcctttgac gtttcggaag aatcttcgtc atgttttgtg taatcataat 742681 cagaaggatt caccttctta aaacctttcg gctcgtagaa ccgcagcagg tctccgttta 742741 tgattttatc ggacatttca agttccttct tgacgagtga gtcttctgac ttgtcgactt 742801 cggattcatc gagttctttt ccggttttcg tgtcgtaata cttaccggat attttcgtgt 742861 acttcggtga aataaagtct ccgtttcgga acggaatcac ttcacggtgt tctttcgata 742921 aaatatcaga accggacatc agatagtcct tcgtatccac tccgagcaga tgcagaatgg 742981 taggagccac atcaacgtct ccggcatatt tatgaacttt ctcgcccttc acgccggcag 743041 cgtggataaa gagcggcacc cgttgaagct gggcgttgtc gtaatcagtg atttcatcct 743101 tgccaagcac tttcgccatc gctttattgt ggttttcaga gatgccgtag tggtctccgt 743161 acatcacaat aatcgattta tcatataacc cgtctttttt cagatcattg aagaattgtt 743221 caatggactg atcaaggtaa tgggctgact ggaaatagtt atcgacgaca gagtcaccaa 743281 agtctccagc cgggaagtct gtatccccct catccattcc gaatgggaag tggttggaaa 743341 gggtaatgaa cttcgtatag aacggctgcg gcaggctttc cagcagcggc attgattctt 743401 tgaagaacgg tttgtctttc atgccgtagt ttttcgtgtt ttcttcgttc atgtcatagt 743461 aagcagaatc aaagaattta tcaatgcctt ccgccttgta catttcgtta cggttccaga 743521 acgtctgcgt gttcccgtgg aaagtagcag atgtgtaatt cttagacttc agaatcgccg 743581 gaacggattg cagcgtgttt tgcgctttgt ttacgaaaac tgaaccttga gccagcgggt 743641 acagagagtt ttccatcata aattcagcat cagatgtttt accttgtccc gtttggtgga 743701 aaaagttatc aaagtagaac gtttcgttat catgtgccag tttatttaag aatggtgtca 743761 cttctttgcc gtcaatttta tagtcgatga taaatgactg caaagattca agtgaaacgt 743821 aaatgacgtt ttttccttcc gctttgccga aatacacgtt attcggcaca tcgtaattgg 743881 ctttcatgta gttttctact tccgttacgt cgctggaatc ggcaagcgcg cgctggctgt 743941 tggacttgat attctgtaca gcgtcataaa tcgtgaaatt gtatgttccc aagtatttca 744001 caagatagtt ccggtcgaat gatcttgtca gcaattcagg acggtctgat tccgcaactg 744061 ccaggttgat caagaacaca agaattgaag acgcaaaaat aattcggaac gattttttgc 744121 ttgacgtttc ggcaggcttg tttactttga tcgccaagat gatcaggatg atcgtatcga 744181 taaagtaaaa ggcgtcagtc ggtctcatca gcgaaaatgc gctgtcaccg agttggccgc 744241 cgtttgtttt agcctgcata atgaccggaa ttgtaataaa atcattgaaa aatctgtagt 744301 acacaatgtt ggcgtacagt aaaaaagaca ttaaaaaatg aatcactata atggctgtct 744361 gctgtaattt tttcttgaac aagagtccaa agccaagaaa gaacaagctt gagctaagag 744421 gattcacaaa aagcaatatt ttttgtatcg tgttgtctat tcctaagttg aaattcagga 744481 cataaccgac atacgttttg atccataaca ggacgaccgc aattaagaag aaggccagtc 744541 ctctttcttt tataaatgtt ttcattgtta cactcctttt ttccgatcca gttcgagcga 744601 aacgatagaa aaaacgaacg tatccaatat aacacgaatc agcagattag aaaagtgaaa 744661 atcgtatgag ggagaaagtg gcgaaaaacg ccgtcgaatc aacgtttcgc tttgatatta 744721 ccaaatgtaa aacaaggtat ctttctagaa ataaaggaat aaaatggtac attgagaatt 744781 gtatgataaa atataaggta tagataaaaa gaggtgaaat gatggatttt tcccatattg 744841 tgtctgaaga taaaattaag cgcgccatca aagacgggga ctttcaaaac ctcccgggaa 744901 tggggaagcc gctgccgaag gatgacgcgg cacacttgcc ggaatcgctg cgcatgggct 744961 atcgtatttt gaaaaacgcg ggaatggcag aggacgaggg cgcgctcaaa aaagagctta 745021 tgaccatcga ccatttaatc gaaaagtgct atgacgaaaa agaacgcgag caattaatca 745081 gaaaaaaatc tgaaaagcaa ttgctgcttg ataagcttgt cgacaaaaaa ggcatgtttt 745141 caaagccagc atccgctttt tataagaata aagtatatga ccggcttgga cgaaacagac 745201 cttcttccag ctgatttgtc ttgtctgcag gatggcgatt gataaaagcc atccttttta 745261 tgttccaagt tctatgtcaa aaggtttatg tttttccatc tatgggaaat gattcataaa 745321 cgaaaaaagg gtgatgggat ggaacgacta ttagtatgga tagagcatat atctgattgg 745381 ctgtggggtc cgccgctaat catcctgctg acggggacgg gcttgtattt cactattttg 745441 ctgaaaggtt ttcaatttcg ctatccttta tacattttca aacagacaat cggcagtgta 745501 ggaaaaaagc cgaagggaga aggcacagtc acaccgcttc aggcattgac ctcagccctc 745561 agttcaacga tcggtgcagc gaacattgtc ggtgtgcccg ccgctattat gtttggggga 745621 ccaggagcgg ttttttggat gtggcttatt gccttatttg ccatggcgat taagttttct 745681 gaaagtgttc ttgctgttca ttacagagaa aaaaatgagc agggtgaata cgtcggggga 745741 ccgatgtatt acataacaaa agggctgcgc atgaaatggc tcggcgtatt cttctctgtt 745801 gcgctgattg tggagctgat tcccagcatt atggttcagg gaaattcggt ttcagtctcg 745861 cttgccgaga cgttttcttt caataaaata tacgcaggaa tcggaattgc atttttgatt 745921 gggttagtgg tgataggagg ggtaaagcgg atcggaaaag taacagagtt tgtcgtgcct 745981 cttatggcag gggcatacgc aggtgccggt ctcctgattg ttctcatgaa tctatcatca 746041 gtgccggcgt ttttctctct cgttttttca aatgcgttta cctcttcttc agcagttgga 746101 gggttcgcag gtgctgcgtt ggcggaaacc gttcgctggg gatttgcccg cgggctgtat 746161 tctaatgaag ccgggatggg aacagccccg attgcacatg cggcagcaat gactgatcat 746221 cctgtgcggc aagggttttg gtctgtgatc ggcattgtca ttgacacctt aatcatctgt 746281 acgactaccg cttttatcgt ccttgcatcc ggtgtatgga cagggaagaa cgcctcaaat 746341 gacccggcag cactgacaac ggccgcattt cagcactatt tcggttctgg aggaggatac 746401 ttcgtttcgg tttccctggt cttctttgtc gtatcaacca ttatggttgt cattttttac 746461 ggcgtaaagc aagctgaatt tctgttcggg cggctggcag gacatgtgat taaattcgtt 746521 tatttagcgg ctattatcat aggtgccgca ggcggagcaa aagccatttg gggcgtattg 746581 gacttagcat tggtttttat tgttgtcccg aatgtgattg cgctcttgtt attgagcaga 746641 aaggtaaaag cgctgtacac cgaattcttt acatctgaac agtactacct gaaagatata 746701 agaaaaacga aacaaaagcc tgtttatcca acaaaagaag ctaaaaattc ctagtgtttt 746761 gcttttgcgc cgaacaatgc tttgcttttt atgatcaaat aaatgagtaa aggcagcaaa 746821 agagaaatca ctacattaat gattggtttg attctgttaa agtcgattag ctgatttgta 746881 tttaaaaaaa accaaaagcc gcatacgact gagaacatgc cggttggtgt atacatggct 746941 ttcgggtcga tttttgagtg taaaaacgaa aggccgtata ccacgatata tagggaacct 747001 gctatcttca ccataatgac cggaatccaa aaagccgcga tgatcaggtc tgagcgatcc 747061 agaaaatccg taatgcggat ctgcctgatg accatataag caggatcaaa gaaagtagat 747121 gtcaggttgg gaccaaagac agaaattgaa gaaaataaca tcacggccag caataaagcg 747181 cccagcagta tcgcgaaaat ggtgtatttt agcgggacgc tccggtttga gaagagaagc 747241 ggaaggataa tcaattcccc cattgtccca aacgcgtaat agcctgattg aaggtatggg 747301 attagacctt caaaaacagg tgtcaagttt tgaagctcaa tttgtgtggc cagcgtaaat 747361 ggaaggaaca agaccaggat gccgaatgga aataggaata tctgcgccat tctggtcaat 747421 gtttcttttc cctctctggc aatacagatc gccacaaaga taataacacc gccaagaaca 747481 gccattggtg ttctcgggag aaataaaatg ttaatcaaat tgatgaaaaa acgtatatca 747541 tgagcattga ttaacaggaa atacaaagaa aacagtaaaa tgataatccg gcctgcgatt 747601 ggtgaggaat cgctcagcag ctcatagata tttttatcct gatgcttttt catcagccta 747661 tgcatgagcc agagtgccgg aatcacgatg acaacgccga ggatgtagct gtgccaggca 747721 ttttgttttg ctgattcgat catgagaatc ggagcatgct ttaatccgac tgctaacgta 747781 tacagagctc cgaaaaataa tccttggtat gcagaggtct tgtccataaa gcacatcctt 747841 tctgtcatgt tcaaaacgga atatatttaa acaggtgccc cagccgcgga agcaggggat 747901 tcactctcat ataaatccat agaaaagcac ttcctgcaat tagcaggctg aaggcccatt 747961 ttgttagatt gttagcggaa cgaaaattct tccattcata tgcgtatatg gcaatgcaca 748021 caatcaatgt ctgtacgata tagctgatca tgctgacgca cctccattaa tggctgatcg 748081 ttttgtatag gacaccgccc tgctcaatcg tcacaattgg gacgacgtga acctccatat 748141 ccttatatac ctcttcccat tcctttttca gcagattctt cgtggttgcc gtgcttctga 748201 tggtcctgtc ttgaaagccg gccgggtccg cctttagctt ttgcaaacga tgaacggtgc 748261 tgatcacgtc cttctttatg gttctgttta atgctttttg aatgatgtaa tactggtcat 748321 tttctctcgt ctcataggtt gattggtttt ccataataat tcctttggct ctgatctcga 748381 ttgtcattga cagctttccg tttttttcag cggcatgaaa ggatgcattg gacttttgaa 748441 gctgaatgga tgcttgcccc atttgattcg gcaggtctac tatgaattct ggctggcggg 748501 cttgattcag caacatcagg gctgctgtca tgtgttcatc tttgaaaata tccatcaatc 748561 tgtccttttt aaagatcgca agcccgtcaa ttttcaaatt agatttgcct ttccctccag 748621 gttttgtttt agatgcagag atgaccggtg catacggatc actgcctatt tctactagat 748681 cagacatgaa tctgcttaag aaaacggggc ggctcgttgc gataatggcc agctcccgaa 748741 tcatttccgc cggaaactgt tcaagctgaa catcggtatt taaaatgtcc cgcgcttctc 748801 cccggctgac taaaatgagc gccgttaatc tgttctgcgg atttcgcgtt aaaatatcaa 748861 agactggggc aacgccgtct ctcgccatat cctctccaat aatgactgta cgtctgtggg 748921 acgtattgat tgtccgtgac aaggaggttt gcagcttgtt gttcgcttct ctgatcgtag 748981 tgccggaagc tgaatcaaca taccatgttt ttgaaccggc agttccgccg ccgccccctg 749041 tttgtccgcc taattggccg accaagggaa tctgcatggc cactcgatac tgatcttttt 749101 tcttatcaat ggctgagctg acaacaaatg caatgtcatt gatttctgtc cggtcccagc 749161 accccgttag aaggatacaa atgagaagcg gcaaaacaca cttatatatt gttttcttca 749221 tcttttgggt cctctctttt cgctcccttc tgtccgttgc cgcgcgaata cgtgcccggc 749281 cttctggtca tcgtccacca aggcgccctg acaaaaatat cttttacttc atctcgttta 749341 aacggagaaa tcccggataa ataaggaatg ccgaaagatt gcagcttgca taaatgaagc 749401 actaagataa tcgtgccgag cataatgccg aatatcccaa aaatactcgc caaaaacata 749461 agcgggaaac gaagcatcct gatggagata gctaagttaa accgcggaat tgtaaatgac 749521 gcgatccctg ttaacgatac gatgatcacc atgggggcag acacaattcc cgcttcaaca 749581 gcggctgtcc caatgactag ggccccgaga atactgacgg tctggccgat ggttttcggc 749641 aggcgcactc ccgcctcacg gagagcctca aaagaaattt ccataatcaa tgcttctatg 749701 atggcgggga aaggaatcgg ttcacgcgca gaggccacac tgaacattaa gtttgtcggc 749761 attaagtcct ggtggtatgt aataacggca acataaatag ccggcaaata taaagcaacg 749821 aataaaaaca tatagcgaag ccagcggatt aagttagaca tcaaataacg ctcatagtaa 749881 tcttcactgg cctgcataag ctgccaaaac gtaatcgggc ctgttaagac aaagggcgta 749941 ttatctgtga aaatggcaaa tcggccttcg agaagctggg cggcgacggt gtccggcctt 750001 tctgtgtatt gcagctgggg gaatggcgag tacgtgtcgt cttcgataaa ttcttcaata 750061 tatccgcttt ctaagacagc atcaatcttt atctttttga ttcttttttt tgctttgtca 750121 ataacctttg gatcggcaag cccgtcaata taggccaaga caacatcggt tttggttttc 750181 gtgccgattt taaaagagat cattttaagc tgaaacgttt tgacgcgaaa gcgcacaaga 750241 gcggtattga ccctgaggct ttcagtgaag ccctctcttg accctctgat ggtcgattct 750301 gttatcggct cttcaatgct tcttctttgt ccgcctttta tatttaagat caggcctttt 750361 gagtgcccgt cggcaaataa aaccgcgttc ccctcaatga tggatgcagc cactttgctc 750421 atactcgttt ctaatgcaac acttgaaatt gatagagtat tttgcagcgc ctcttcatgt 750481 tcatctattt gatccgtcaa atgcattaag aaagggcgga gggcgtgatc ctgaatatgt 750541 tcagatttta caattccttc gatataaaca ataaatccgc acagcccgtt tccaaagtca 750601 aattgtctaa atacgatgtc tgagcagcct tctgttaata aggtcagatt ttcgaggttt 750661 tccttcaaat tgggagagat cggtctgtcc tgattgtctt caagctcttt gatgagctga 750721 agcgctttgt cgcgtttatt catagaggct caccctgctt tttaatgtca tattcaataa 750781 gtgcttgtga cttttagggt aaccttgtct gtttcatata ttccagacta ggatgaaagc 750841 gctataaaaa agtgttgact acctgtatat acaggaatac aatatgatta taagttgtat 750901 atacaagtta taaaaacgga tacggagggg ttggcatggg ggaactgaac aaatcggcac 750961 gtcagattgt cgaagcagtc ggcggtgctg aaaatattgc agcggcaact cattgtgtta 751021 cacgtttgcg ttttgcttta atagatgaaa gcaaggttga ccaagagatg cttgatcaaa 751081 ttgatgtggt aaagggatca ttctcgacaa acggacagtt tcaggtcgta atcggccagg 751141 gaactgtcaa taaagtatat gctgaactgg ttaaggaaac ggggattggc gagtcaacaa 751201 aggatgaagt gaagaaggcc tcagaaaaaa atatgaatcc tttgcagcgt gctgtgaaaa 751261 cgcttgcaga tatttttatt ccaatattgc ctgcgattgt cacggcgggt cttttaatgg 751321 ggatcaataa cattttaacg gcggaaggca ttttcttcag cacaaaatcg attgtgcagg 751381 tttatccgca gtgggcggat cttgctaata tgattaacct gattgcaggc acggccttta 751441 cgtttttgcc tgcgttaatc ggatggtctg ccgtcaagcg gttcggcggc aatccgcttc 751501 tcggcattgt gctcggggtt atgctcgtgc atcctgattt gctgaatgcg tggggatatg 751561 gcgcggcaga acaaagcgga gagatcccgg tatggaatct attcggccta gaggtgcaga 751621 aagtcggcta tcagggccag gtgctcccaa ttttgcttgc ttcttatatg ctggcgaaga 751681 ttgaggtatt tttaacaaaa cgcacacctg agggcataca gctgctcgtt gtcgcaccaa 751741 ttacgcttct cttaacagga tttgcctctt ttatcattat cggcccgatt acatttgcga 751801 tcggtaatgt actgacttca gggcttatct cggtgtttgg ttcttttgcc gcactgggcg 751861 gtctgttata tggcggtttc tactcagcgc tcgtgattac cggtatgcat cacacgtttc 751921 ttgcagtcga cctgcagctc atcggttcaa agctcggcgg caccttttta tggccgatgc 751981 tggcgctttc taatatcgca caaggttcgg cggctctggc catgatgttt atcgtgaagg 752041 atgagaaaca aaaaggcctc tccctcacat cagggatttc tgcttatctt ggcattacag 752101 agcctgccat ctttggggtg aatctgcgat acagattccc gtttatcatt gcaatggtca 752161 gctctggcct ggccggaatg tatatttctt ctcaaggtgt gctggcaagc tccgtcggtg 752221 tcggcggcgt gccggggatt ttctcaatca tgagccagta ctggggcgcg tttgcaatcg 752281 ggatggctat tgtattgatc gtgccgtttg ccggaacata cgcgtatgcg agattcaaac 752341 ataaataaca agtggggagc gggacgtgtt gaacgttccc ttttcccgtt ttcaatttaa 752401 atatggtggt ggaaacagat gaaaacagaa caaacgccat ggtggaaaaa agctgtggtt 752461 tatcaaattt atccgaaaag ctttaacgat acgacaggaa atggtgttgg cgatctgaac 752521 ggcattattg aaaagctgga ttacttaaaa acgctacagg tggatgtgct ttggctgacg 752581 ccgatttatg attctcccca gcatgataat gggtacgata ttcgtgatta ttactcgatt 752641 tatcctgaat acggaacgat ggaggatttt gagcggctag tgtccgaagc acataaaaga 752701 gacctgaaag tcgtcatgga tcttgttgtc aatcatacgt caacagagca caaatggttt 752761 cgcgaggcga tctcttcaat agacagcccg taccgtgatt tttatatatg gaaaaaaccg 752821 caggaaaacg gttctgttcc gacgaactgg gaatcgaaat tcggcggctc ggcatgggag 752881 cttgacgaag catcgggcca atactatttg catctgtttg atgtgacgca ggctgatttg 752941 aattgggaaa atgaagaggt cagaaagcat gtctatgaca tgatgcattt ttggtttgaa 753001 aagggaatag acggctttag gcttgatgtc atcaacctga tttctaaaga tcagcgcttt 753061 ccgaatgcgg aggaaggcga cggccgctct ttttacactg acgggccgcg ggtgcacgaa 753121 tttctgcatg aaatgaacga aaaggtgttt tcacattacg acagcatgac ggtcggtgag 753181 atgtcttcaa caaccgtaga ccactgcatc cggtatacga atcctgacaa taaagaactt 753241 gatatgacat tcagcttcca tcatctcaag gttgactatc ctaacggcga aaaatgggcc 753301 ttggcgccgt ttgatttttt gaagctgaag gagatcctat ctgactggca aacggggatg 753361 cacgcaggag ggggatggaa cgctctgttc tggtgcaatc atgatcagcc gcgcgtcgta 753421 tcaagatatg gagatgatgg cgcatatagg gtgaaatcgg cgaaaatgct tgctacggcc 753481 attcatatga tgcagggcac gccttatatt tatcagggcg aggagctggg gatgacgaat 753541 ccgaagttca ctgacataag ctcctatcgg gatgtcgaat cgctgaacat gtatcacgcc 753601 tttaaggaaa aaggaatggc tgatcaagat attacagcca ttttacaggc gaaatcccgt 753661 gacaattcca gaacccccgt tcagtgggat gctacggaaa atggtggttt tacaacgggc 753721 acaccatgga taccggttgc aggaaattac cgggaaatca atgctgaagc ggcgctgagg 753781 gatcagaatt cggtgtttta ccattatcaa aaattgattc agattcgcaa aatgtatgac 753841 attgtgacag agggtacgta tgagataatt gcaaaggatg acccgaacat ttttgcgtat 753901 ctcagacacg gcagcaatga aaagctgctc gtgatcaata atttttacgg gacagaggcg 753961 gcctttacac tgccggactc tttagcgcct gacgaatgga aggcagaggt gctgttgacg 754021 aacgatgaag caagggaagg gcttcagaac atgacgcttc gcccatatga gtccattgtt 754081 tatcgtttaa cgaaaccgtg ttaaactaag ctgggtggtc cataatgaag gtgaataaat 754141 tcatcacaat ttataaagac atcgcacagc aaattgaagg cggccgatgg aaagcggagg 754201 agattcttcc gtctgaacat gagttgaccg cacagtacgg tacatcaaga gaaacggtcc 754261 gaaaggcgct tcatatgctc gcgcaaaacg gttatatcca gaaaatcagg ggaaaaggct 754321 ccgtcgtgct caatcgtgaa aaaatgcagt ttcccgtttc gggccttgtc agcttcaagg 754381 agctcgcgca aacgcttggc aaagaaacga aaacaactgt acacaaattc gggctggagc 754441 ctccgtcaga gctgatccaa aaacagctcc gggccaatct ggatgacgac atctgggaag 754501 tcatcaggtc tagaaagatt gacggggaac atgtgatttt ggacaaggat tactttttca 754561 gaaagcatgt ccctcacctg acgaaagaaa tttgtgaaaa ctccatatat gaatatatag 754621 aaggagagct cggtctttcg atcagttacg cccaaaaaga aattgtagcc gagccgtgta 754681 cggacgagga cagagagctg ctcgatttac gcggctatga ccatatggtc gtggtgagaa 754741 actacgtctt tttggaggat accagtttgt ttcaatatac ggaaagcaga caccgtctcg 754801 acaaattccg atttgttgat tttgcgcggc gggggaaatg agagaggcgc ctgcctgcgg 754861 cagcgcgctt ttttgtttgg tatcaaaatt gatactatcc aacaaaaatg tgcgtacttt 754921 tactttttat cataatggct acaatagaga tgagagtaat ctaaaggaga ggtgttttac 754981 atggcagatc taaagacaca aattctggat gcatacaatt tcaggcatgc gactaaggaa 755041 tttgacccga ataaaaaagt gtcagacagc gattttgaat ttattttaga aacaggaaga 755101 ctgtctccga gctcactcgg ccttgagcct tggaaatttg tcgtcgtcca aaatccggaa 755161 ttccgcgaga agcttcgtga atacacatgg ggcgcgcaaa agcagctgcc gaccgcaagc 755221 catttcgtcc tgattcttgc gcgtacagcg aaggatatca aatataatgc ggactacatc 755281 aaacgtcatt taaaagaagt aaaacaaatg cctcaagacg tgtacgaagg ctatttaagc 755341 aaaacagaag aattccagaa aaacgatttg catttgcttg aaagtgacag aacattgttt 755401 gactgggcat caaaacaaac ctatatcgcg cttggcaaca tgatgactgc cgctgcgcaa 755461 atcggtgttg attcctgccc gatcgaaggc ttccagtacg atcacattca ccgtattctt 755521 gaagaagaag gccttctgga aaacggaagc ttcgatattt ctgtgatggt ggcattcggc 755581 taccgagtga gagaccctcg tccgaaaaca agatctgctg ttgaagatgt tgtgaagtgg 755641 gtttaaaaga agaaagctgc tcgcatagcg agcagctctt ttttatgcct gattcgctct 755701 attctgtttt ctcctctgat gtaagtacat tgccgttccg agtgcgctga tcagaaatcc 755761 ggccaacagg atcgagtaca tggatgtggc tgtgtccgga agcaggccgc cagccggacc 755821 gtctgttcct gatccgcccg aaccgtttcc accagagccg ttagtcggtt gagtgccggg 755881 aggcgtatca tttcctccgt ttccgtcagt tggctgtttt ccgcctggtt tgtcggagcc 755941 tccgccatga ttgccgtcat caccgcctgt cggttgatct gacgggaatg ccggcggttt 756001 gttgtttgaa ccggaattta agatcgtgta ttcgctgaag tggtttgtat atcctgtcac 756061 catatcatca tcgactgatc cgtgacctgt ctttgtgaaa gctttctttt ttctatcgac 756121 gtgataaatg gcagggttat gggcttcttc aatatcaaac atgcgaagcg aaagctgtac 756181 gggctccttg aatgatttta tttcttttcc tttttgcttc actgtaaagt catatacatc 756241 tgacagtgac acatccaatt ctcccgtaga cttgattccg attgcagtgt ctgcggtttt 756301 aaggttcgcc attggcatct tcatgctgta ccagtagttg aacatcgtca atgaaggatc 756361 tgactctctt tctttcaaaa gtttgacctg atcttttttc actttaagat tgataggctt 756421 ctcttgagat ccttcatgta ttccataata gacaaatggc gtgttggcat ttttagcata 756481 aatcgcaaat ttgtcttcat caagtgtcca gctgccgtcc ttctgctttg tcggcaggaa 756541 tacttctttg attcgtcctt caactttagg agagaccttg tttcctagtt ttttcagctg 756601 ttcggtgaaa atctcataat caacgtagcc aaggtcttca ccatgggagg cttctgtaaa 756661 gacagaatat ccgtctcctc cggcaccgac aaaattattt gttgccacgc ggtaggtatc 756721 atccgtattt atagcaactt tgtctccgtt aggcgattca attttcactt ctaacacacg 756781 gtgtccaggt ttgttgttta atgtaaaggt atattcgatt ccggccacct gagggaaagc 756841 gccgccgcca ttttccacat tgcttaggcc ttgttcaagg gcttctttaa tttgttttcc 756901 ggttaaatcg gccacgtaaa gcgtattgcc gaacggcatc acgttgagca cctcgccgag 756961 tgtgatatca cctttgtcaa tgcctgctct gatgccgccg ccatttgtta tcgctattct 757021 ggcgccggct gcttctttcg cttttgccag cataccgtcc gcgatgaagt ttccgagatt 757081 cgtttctttc gtgcgcacat gctcacgctg gccgtcaagc gccacatccg tgtagccgac 757141 tttttcattt ttcacgtcct ctaattcatt tttgaactga tcgagctctt gttttgcttc 757201 tgggttttct tctgtatgtt catcaattgg cagcacgctc agatttgatt tatctgtttg 757261 cacaacgcct ttttcatcaa acgcgacatc aacgcgcccc aagaattggc cgtattcttt 757321 tgcctgcgcc acgatcgtcg gttcttcgtt gttcacgacc tccattttgt ctacgagggt 757381 gtgagtgtgt ccgccgatga tcaaatcaat gccttttact tttttggcta gctcaagatc 757441 ccggttatgt ccgatgtggg ttaaagcaat aattttattt accttttctt cttcttgaat 757501 cgctttgacg gtgttttgtg ctgtttcaaa ggcatcattg aatacgatgc ttttgcccgg 757561 gcttgatgtg gtggctgtat cttctgttgt caggccgaat acggcgactt tctccccgtc 757621 aacgtctaac agaatgtaag ggtgaatgcc ggcctctttc ttttcacctg ccgtaaaggt 757681 ttgcggcttt ttgacaaatg atttcagctt gggctcattt gacacatcta cgtttgcact 757741 gacaatcgga aattccggcg cttcaaagtg atagcggttc gccggatcaa cggttgcgct 757801 gtttccgctt agaaaatcag aaagcaccgt cgggcctttg tcaaattcat ggtttccgaa 757861 ggtcatggcg tcatagccca tcatgttcat cattttcaga tcggccaaac cgttccattt 757921 agtaaaatac agatcgccgg aaaacacatc tcccgcatca aggagaatat tgtgatttgt 757981 ttcgctgcgt acttcgttga ttttcgtcat tcgtctcgct gcatcatcga gatgggcgtg 758041 cgtatcattg gtgtgcatga cggtcagatc ccacagtccg tctttaggag gatctggatt 758101 tgaatcatca tcgaattgca gcttatacac accatagcct tcattcgcag acttgcctac 758161 ataagcgaca tcgtctgctt tatcggcaaa tggcttggcc aaaagcgagg attcaaacgt 758221 cagattcgtg ccggaaacag gcgcgattga ccagttgttg tctgcttttg gattgactgt 758281 tttttgttca ataatgtaat ccatcagcac ctgcctattt tcaactgcag agccgtggac 758341 aattttatcg ctcgtcagat gagggaaccc gccgcctccg gacgcacgat agttattggt 758401 gactacgaga aattcctggc ttgggctgat cggcttgcct tcataggaaa gattgatgat 758461 acgggatgaa tccgcattga tcacttttcc gttctcattg tatttagccg gttttgtcac 758521 atcgacctga tatgtgacac cgtcaatcac gtcaaaatta taggagcgga aattctcgtt 758581 cagcaaggcc tggtcgccgc ctttagctgg atcaatttga ttgaattggc ctgctgacat 758641 ctccagccag tccttgacct cgctgcctgt cagcttgacg atttgaacag tattatcgta 758701 aagatacaag tcaccgacat ttttaatcgc aagatctccg gctggaatgt ttgtatagta 758761 attggctccg tttctgccgc ctgctttaaa cggcgctcca gcggataaaa tcggcaggtt 758821 cttgtactcg gtatccttca tttctttttc agcgtaccac ttttgcgcgt cagtcacgat 758881 ctgaatggaa ggatcatctt tgacctgtgc aaagaagctg ttaatatctg cttcggtttt 758941 gccgactggc tttcggacat actccagtgt gttttggtgt gtttgctgaa tggtgtttgt 759001 aacggtttcg tttcttgatg tgacgttgcc agcaatagat tcaatacttc ctttggaatc 759061 tgctaccttc catgagccgt ccgccttttc aagcttgagg tcaatcacgc ctaaatattt 759121 gccccagctg cttggcatga cgacaggaat gccgttaatt gttccctttt ccacattgaa 759181 ctgagcaaca cccgcatact cggcggaagg aaagagtccg tgctgatggc ccgagataat 759241 cgcgtcaatg cctttcgttt tggtggcaag gtcaaacacg gcgttttctg cgcctgatga 759301 ttgcgcctgc ttttcaatgc cggtgtgggc gagggcaata atgacatctg cgccttccgc 759361 cttcattttc gggatcgttt cattggcgga ttctacgata tcctgcacct gaacttgccc 759421 ctcgagattc tttttgtccc atgtcatgat ttgcggcggg acaaagccta tgtagccgac 759481 ttttactttc tgctcattac cgttttcatc aatgagggtt ttttcattaa tcacatacgg 759541 cgtataacgg ttttcgccgc tagttgtttt gacgttggca tttacaatcg ggaaatcggc 759601 tcctttgatt gtgccgtcga gaaagtcgag cccgtagttg aattcatgat tgccaagcgt 759661 tccggcgtcg tatttcagcg cattcatgac gctgataatc ggatgggttt tcgtgccgga 759721 gataatgtcg tctttttgat atttcaccgc gtattcaccc agcggattcc cttgaatcaa 759781 gtcgccgtta tccacaagca gggtgttagg gttttgctcg cggtgctttt ggatcaattg 759841 cgctgttctc gccagaccga aatccgccgt ttctttgtcg ctgtagtaat cgtaatccat 759901 catgttggca tgaatatcag tcgtagccaa aatactcaga tgcacctgag gagccgcgct 759961 ttcttctgca tgaatgggtg gtgttgggag gattaggcta agtatcataa ttgggggcaa 760021 aagaatacgg agaatgtttt cgacgtgtgt tcgtcttttc tgtattctca ccagttctcc 760081 acctttcaac gaaatttgtg ttacagctcc tattgtaaga atattttgta actatttgta 760141 ggtgtttctt tatgattatt gtaaaaggga gaaaaatgag tattatgtag cagtatcaaa 760201 cgacaaatac tgggcattta tgcttatcgt ttgtcacaat cgcggaatgt ttattttagt 760261 gtggctgggg tagagtgttt tatgtagaca tataaagcgg gaggttatga atcatgggga 760321 aaaaaattgc agttgtttta acatattatt ttgaggacag cgagtacact gagcctgcga 760381 aagcctttaa agaagcggga catgaactga ctgtcatcga aaaagaaaaa ggaaaaacag 760441 taaaaggcaa gcagggaaca gcggaagtga cggttgacgc gtccattgac gacgtaaatt 760501 cttcagactt tgatgcgctt ttgattcctg gaggattttc accagaccag cttcgcgctg 760561 acgatcgttt cgtccaattt acaaaagcgt ttatgactga caaaaagccg gtatttgcca 760621 tttgccacgg cccgcagctt ttaatcaatg cgaaagcgct cgacggccga aaagcgacgg 760681 gctatacgtc cattcgtgtt gacatggaaa acgccggtgc cgacgttgtg gacaaggaag 760741 tggttgtttg ccaggatcaa ttggtcacta gccgcacacc ggacgatata ccggcattta 760801 accgcgagtc attggcattg cttgagaaat aagaaaaaac ggacgctctt gggcgtccgt 760861 ttttttgttg cttaggcttg agcacctgtc agtttcttgt acctgtaata caagaaagca 760921 gctgcagccg ttccgatgac cgcaatgccg aagtcgaata tgaaaatatg ggcgatgccc 760981 cccgcttttg cgataagccc tgttgcaatc ggcagcagaa tcgatgcaag acttgaagca 761041 gtcgctacaa ttccggtaac ggttcctttt cgcttccaga aaagctctgt cattaacgta 761101 atggtaattt gaaacacacc cgcagttgaa aagcctaaga aaaaggcagt gatgtccagc 761161 acaactggga tatgaacggt cagcatgact gcgagcgtac ataaagtaat aataggatat 761221 aagagcgtta tgaagacagg tttgacccat ctattcagca aaacggctaa taataaaaca 761281 gatgccagag atcctatact ataatagctc agcaattgta cagatgctga ttcagctaaa 761341 ccggctgcct tttgcgcgta gctcgggagc cagatttgag aaaccgtaaa taaagccgtg 761401 gatgtaaaac cgatgataat cagtgcggtg ccttccttct gaaaaacggg ttcagacaag 761461 aaaacgggag attcctgttg gccgctatta gttggtttct tatgtttttt aggaaacgaa 761521 agcgttgata aataaataat attcaggaga tagaccgctg ccggcagata aaaagcaaat 761581 ccgtaaaaca tgctgtggtc tgctaaaaat gtgatcaaaa gcggcaaaag tgcggccccc 761641 acagacataa aggctttaac caagacattt gccgaaccgg aagcagacgg aaagagctcg 761701 gttagggccg gatatgttcc ggcatccatg gctgaattag cgactccggc taataaagcg 761761 aacacaaacg ccagctcata gctcggtgat aaaggaatac cgactaaaaa gacggccata 761821 attcccgcag aagcgacaac aagcggcttt ctgccgattt tatctgatag aacgccggaa 761881 atgccgtatg tcagcagttt gccaaacccg atagcggcaa tgacataact gatgccggtc 761941 ggatcggtat tccactgttt tgttaatgaa gacatattgg atgcgagaat gatgttgacc 762001 atccccagaa agaagtagtt gatatacatt ccggatgctg ttttgataga tgtcgtttgc 762061 atgcttgtac tccttcaaat cttattcgaa cactttgctg ttttggtttg gggaaatgat 762121 aaaaaagact cgccgagttt ccggccagtc tccattattt acgaagcgag gctaattctt 762181 gagcaatcgc ctgcatttca cttgggctga atgattcttt tttcatcacc attctgtgaa 762241 ggtacgtgag gtcttcaatc ttctcatcac tgaaatcctc cgctttgatt acgccgacgt 762301 tcagcatgtt cagcttttgg gaaatctctt caatcatttg agttaatgtt tctgtatttg 762361 ggctggacaa agggttccat cctttctatg cgcaatatag gtatgtttta ttctaacaga 762421 attccatcag aaaaaaaccc tattctaaaa gcaggctgtt cattccaaaa aagtgaagac 762481 atcagttgaa aagaaaatga acatcctact aagatattca tgaaggtttc tttttagaga 762541 aataggggca aagaataggg aggttgcaca tcatgataag cgtgttattt gtttgtttag 762601 gtaacatttg ccggtctccg atggcggaag cgatttttag ggacctggca gccaaaaaag 762661 gattagaggg gaaaatcaag gcggactcag ccggtattgg cggctggcac atcggcaacc 762721 ccccgcatga gggaacgcag gagatattgc gcagagaagg aatcagcttt gatggcatgc 762781 tggcgcgtca agtcagcgaa caggatctgg acgattttga ttacatcatt gcaatggatg 762841 cagaaaatat cggaagtctc agaagcatgg cgggttttaa aaacacctcg catatcaaaa 762901 ggctcttgga ctatgttgaa gattcagatc tggctgacgt acccgatcct tactacacag 762961 ggaactttga agaggtctgc caattaatca aaacgggctg tgagcagttg cttgcatcca 763021 ttcaaaaaga aaaacaattg tgagtgaaag gagaatttgc atgaacaacg aacgtttaat 763081 gctgaaaggg atatttctcg gagctgcggc aggcgcggcg ttatcactgc tccataagcc 763141 gacaagacag gcgtgcggga tgagatggct gacatgcaag cataaacttt cactgtacaa 763201 aagcaaccca gagctgttaa aaaacactgt catcacaaaa gtggatgagg ccaaaaagct 763261 cgcccgaacg ctttcaaagg aagtcgactt tgtgaaccag caggtgaaag agctgaagaa 763321 aacaacgccg caagtgatgg aactcgtgca agaaacgaaa gagcattttt caaaaaaatg 763381 atcaaacatg cgaggtgaga cgacatgagt tttttgaaag agcttttcag cagatacacc 763441 cttcatgaag gacaaagtaa atcagcggag ctggcgtatt tttttctatt gtcactgttt 763501 ccgtttttga tttttatgct gacgctcacc gcgtatcttc cgctttctac cgatgatgtt 763561 ttaggagtca tagaacaata tgctcccgcc agtgcgatgt cactcgttga atccattacc 763621 catcaaacct taaataatcg aaatggcggt ttgctgtcat tcgggattat cgccgcatta 763681 tggtctgcgt ctaatggaat gaatgcgatc gtccggtcgc tgaaccacgc gtatgatgtg 763741 gaagaaaacc gctcttttat cattgttcgt ctaacctcga tttttttgac gattgccatg 763801 gtatttacga ttttagtggc tttgcttctg ccggtatttg gccgggagat tggaaggctc 763861 gcttctgact ttgtcggcgc gtcggatctg tttttatccg tctgggccgc cattcgctgg 763921 ggtgtcagcc cgcttgtgct tttgattgtt ttttccgcgc tgtatgtgat tgcgccgaac 763981 aaaaagctgt ctctccggtt tgtcatgccg ggtgcggtct ttgcgactat cggctggatc 764041 attgtcagca cattgttttc attttacgtc agcacgtttg cgaactatag cgccacttac 764101 gggagcatcg ggggaatcat cgttctgatg atttggtttt acttgagcgg cattttaatt 764161 atcctaggcg gagaaatcaa cgctctttta cataaacgta aaaagcttcc tgatgaaaat 764221 ccctaccatt agcgcaccct ataaacgaac ttcggttcaa aaagaagtcg gggggatatc 764281 gtgatgacca agcatacgaa aaaaggcgga agccataaca aacaaaactc gaaaagcaaa 764341 tcgagccata aaacaagcgg aagcgccaac ggacaaaacg gctaccatta gcataaaagc 764401 ctcctgacat gatgtcggga ggctttttga ttaagaagat gaagaatagg tttcagccgg 764461 tgaccagctt ttcggtttgc ccagcacaag ggccagccac acagagctaa gcgtgagagt 764521 aatgaagtag aacaagtttg cgctttcaaa tgtctgcata taccagccgc cggcaactgg 764581 gccgaggatg ctaccgagac tgaatgtaat gccgcaaagc aggtttcccg ccggcaggag 764641 gtgaggcgga agaaggtctg tcatatagct gatgccaagt gtaaaggttg atccgactgc 764701 cattcctgca ataaaaaagc agccgccgat cacgtagggc gaaggaaata caccggcgat 764761 gaaaaagcaa agagccccag tcagtaaaat caccagcagc acattccgcc tgccgtattt 764821 atcgctgagg atgccgagcg gaaactgaaa gataatgctt ccaatcgcaa atgcgggaag 764881 gatgatcgct actgcgtcta ctgatatccc caaacggagc gcgtacaccg gaaagcttcc 764941 gttcagcgcc gtttccagaa agccatagcc aaatgtaggc ataaaggcaa cccacccaaa 765001 cagcatggcc tgataaaatc gcctgaaact attgtctgat ttggtttcat gaggactggt 765061 ttccgggtat gcattttgta gaaagaaaac aaaaagccac gcaaacagac tgatgcagcc 765121 ggacacgata aaaggaagcg acggactcag cttgacaagc ggcaccatga acgggcctgc 765181 ggcaaagcca aggccaaagg aaagcccata aatagacagg tttcttccgc gattttgttt 765241 tgatgacatg gaggtcaccc acgtttgcgt agaaaagtga agcatgtggt cgccgattcc 765301 aatgaacagg cgaagcagga accagaccca aactgactga agccaaataa atccgaataa 765361 gcttaaaatg acaatgcttc cgcccatgac gatcagcggc ttgaacccga gctttctgag 765421 cggtgcttcc ataaacggcg aagccaaaag cacaccgata tacagcccgg tcgcgtgcag 765481 gccgttgata gcagcggatt ctccatttgt ttcaaaaatg attgaaatga caggcagcag 765541 catgccttgt gaaaacccgg aaatggaaac gagcaagaca aggataaaga aatgaaatcg 765601 tgacatcgtg tcagttctcc ttatatggaa tctatgttga tcgtacaacg ttttccaaaa 765661 gcaggcaacc tgaaaaaagc ctatatcacg ctatacattt gccctcgtgt aatcatgaag 765721 gtttttgtga agaataaaaa taaaacaagt cataaaaaag gagctatttc accatgaatc 765781 gtatcttttt tattttagtg gcggccggtg ttccgctttc tgtgattggc agtttgatgc 765841 attggccttc cgcggttcta tttgcagttt attgcgtgac gattatcgcg cttgcaagct 765901 atatggggag ggcgacagaa tcactgtcca tcattgcagg accgcgtatc ggcggtttgt 765961 tgaatgcaac cttcgggaat gcggtggagc tgattatttc cctttttgca ttaaaagaag 766021 gcctgacagg aatcgtgctt gcctctttaa ccggttcagt gctggggaac ctgttgctgg 766081 tagcgggcct atcgtttttt gtcggcggtt taaaatataa gcggcaggaa tttaatatcc 766141 atgatgcccg ccataactcc gggcttctga tttttgccat cattgtcgcc tttgtgattc 766201 cggaggtatt ctctgttggt atgggaaacg ccagcaagct caatttaagc atcggcatca 766261 gcatcattat gattctgtta tatgtggcgg cgctgtactt taaacttgtc acgcatcggg 766321 gcgtttatca gccgaataat gccgctcaga ctgaagaaga ggaagagcca gaatggtcag 766381 ggaaggttgc gacgattgtc ttgtttgcgg caacgattgt ggttgcatac atatccgaaa 766441 acctggtcca tacctttcac tcggtggctg aacagttcgg gtggagcgag ctgtttattg 766501 gggtcatcat cgtggcgatt gtaggaaatg cggcggagca tgcgtcagcg attattatgg 766561 ccttcaaaaa taaaatggac attgctgttg aaattgcagt aggctctacg ctgcagatcg 766621 ctatgtttgt cgcaccggtt ctcgtcatct gttctatctt ttttccgaca agcatgccgc 766681 ttgtatttac attgcctgag ctcgtcgcga tggtatcagc ggttctcttg atgatcgcga 766741 tttcgaatga cggggattcc aactggtttg aaggggcgac actgcttgct gcatatgtca 766801 ttatggcgat cggctttttc cttctttaac ctgaaaaaat gatggataac aacaaagcgg 766861 gatgaaaaga ctaagggaaa atgccataga aagagtgata tgatgaaaaa gctatttcat 766921 tccacactta ttgtgttgtt attctttagt tttttcggcg ttcagcccat ccacgcgaaa 766981 aagcagttta aggttcctaa ttctgtcgca agcatttcaa aggaaaacac gtatccgaat 767041 gcttcacagg atcagccaat gcttcagccg agcaagctgg caaaggaatt gctcgatcat 767101 tctgaggtaa agattgaaaa tccgcatctc atcaaaatgc tgaatgaatc caacatatcc 767161 ggcacaccgc ttgcagtagg gtaccgggcg acaatatttc tcgggaaatg ggcgctcggc 767221 tatgaatcaa atgaaacagt cgcaaactgg gaatataaaa aaatcaatac aaaccgtgcg 767281 gataaccgcg gcgggaaaga aacggctgaa atgcattatg cccaggaaca gcagtacaga 767341 gtgaagggcg gcttgacagc taaagttcca aatgctgaag atgtcaaaag catgatgatg 767401 caaaaagcaa tgaagaaaac gaacctcccg cttgcatttg agacggtcat cggggctggc 767461 acaaaacggg atcagattta taaagtcgct cctaaaaaaa tcggttatct acatgcatat 767521 gcaccggctg tgaatgaaaa aggaaaagtg acttacggag aagtgtactt agtgctgaaa 767581 ggaaataaac gaaaactcgt cgtgaaaaat gtcacgtcac agggaatcgg cgcgtggatt 767641 ccggttcaag atcatgtcac gtttggcttt cagctttcct cactgccaag ataaataaaa 767701 aactgattcc aactcggaat cagttttttt gtttattggg ttctctcgat tcggaccgct 767761 tcctcaagca tttgcacatt gttttggtag agctggcgaa cgagaacccg tcttactgca 767821 aggctggcac tgaaataatc atcatctttc accatgcctt taaccgtaaa ttcgacgccg 767881 cgattgattt tattcaatgc ggtgatgccg tggatttgaa acggttctgt cggattgccg 767941 aattcatccc gcttcaatga atcacgaagc tcttcattca gcatgtcaca tgcctcttcc 768001 aacacgctgt acacgcggtc cggatcttct ttaaagctga taagaaagga ttcggtaatc 768061 cgcataaaat caatattata gttctctatt tgtctgacct cgccgttgct gatggtgagc 768121 agcttcccgc tccattcccg gatttgcagc gagcggaggc cgatttcctc cactgtcccg 768181 ttgaacaagt tgttgacggt gacataatcg cctttgtgca gctggcgttc atatattaag 768241 aatacaccag ccagcacatc tttgatcagc gattgggcgc caaaaccgat cacgatacct 768301 gctacgcccg ccccggccaa tatcttgccg aaatcatgca caaataaaga aataacgtaa 768361 aagataaaac caattgttgc cgtatactgg gtgacagaac ggacaaggct ttcaatcgtt 768421 ttttcctttt tttcttcaat aaagtccgtc cgtttaaaaa atagctgtac cagccggttg 768481 atgataaaga caccgatcca aaggataacg gcaacgagga gaatatcgac gattttattt 768541 tgaaaaatct ccgtaagtgt ttctttcatc cgcatctaac tcctggcttg acgttttgtg 768601 aagtctgtat cctgataata actgtttttg acaagaacat tcggtccgag gcaccggaca 768661 ttcgggcagt ggcaactcag ttctttcgca agcttggtct ctctccactt ttcataggcg 768721 gaagggaggc tgtccgtctg aatgttgcca agcggcgggg tatcaccgaa atcggtcacg 768781 ataatgtttc cgtcgaaaat gttcacattc aggcgggatc ggccgtcagg gtcatttcgc 768841 actgtgacgt ttttcgccgc gcgaagccgg cgaagcagct tttggtcgtc ttcgtccgga 768901 ctgcaggcat aaaacggcag cgttccgaac agcatccacg tattttcatc acgaatatcc 768961 agcaagcggt gaatggcctg tctcatctct ttcaggctga gggattcaag agcgcttgcg 769021 aaatcgcttg gatacattgg gtggacctcg tgacgctgac atttcatatc ttctgtgatt 769081 tggcggtgaa tatgctcaat atgcggaagt gttcgtttgt tcagcatcgt ttccgcagat 769141 accattactc cggcatccac gagcgtgcgg ctgttttcga tcattttttc aaaatagcgc 769201 gcgcgctgtt cgaaggtcgg ttttctgtcc atcatggcaa agccgatttc agcaaaatct 769261 tcaactgttc cccagttatg tgaaatatgt agcacatcga gatacggaat gatccattcg 769321 taccgctcga tgtcgagggt cagatttgaa ttaatttgtg tccgcacacc ccgttcatgg 769381 gcatatttca ataaaggaac aacatattct tttactgatt tcaacgaaag catcggctct 769441 ccgcctgtga tgctgatgga tctgaggcgc gggatttcct ccagccgttt taacagaaga 769501 tctattggca gagcattcgg gtctttaggc tgcaatgtat agcctacagc acaatgctcg 769561 catctcatat tgcacagtgt cgttgttgtg aattcaacgt ttgtcagctg catgtctccg 769621 tattggtcaa catccatata ggcttcccaa gggtcaaact cgggcgtaat cggacgcagc 769681 ttcgtgtttt gtgtcatgac tatctaactc ctttataaat gggcatacta acgctgccaa 769741 cagttaattt tagacctgat ttgccaagat cgcaagtagc gcggcgattg aaaaacggca 769801 aaaaatgagc taccataata aaaaatgaat ggaggaacag aatggggaac gccgtaaaca 769861 ataaagatca gcagattgat tatttaaaga acagacttga catgtttatg aacgtcatcg 769921 attcattaga ccctgaagca accgacgttg aagatataga caggcttatc agcatgcttg 769981 atgacctgga agccaaatac gaacgtttta aaaaagattg ggaataaaac cgcgtgcccg 770041 ccgcggtttt tttattggca taaagcaaca gtataaaaca aagtctctat ctgtaaaata 770101 agaaaaaatg cagaaggagc gctggccatg aagtggatgt gttcaatatg ctgcgccgcc 770161 gtattgcttg ccggaggtgc agcacaggcg gaagcggtgc cgaatgagcc gattaattgg 770221 ggctttaaac gaagtgtcaa tcatcagccg ccagatgccg ggaagcagct gaacagttta 770281 attgaaaaat atgacgcgtt ttatttaggg aatacaaagg aaaaaacgat ttacttaacg 770341 tttgataacg gatatgaaaa tggctatacg ccaaaagtgc ttgatgtctt aaaaaaacat 770401 cgcgtaacag gaacgttttt tgtcaccggg catttcgtaa aggaccagcc tcagctgatc 770461 aaacgaatgt cagatgaggg ccatattatc ggcaatcatt cctttcacca tccggattta 770521 acgacaaaaa cagctgatca gattcaggat gaacttgatt cagtcaacga agaggtttat 770581 aaaattacgg gaaagcagga caacctgtat ttgcgtccgc cgcgcggcgt gttcagtgag 770641 tacgtactga aagaaacgaa acgcctcggc tatcaaaccg ttttctggtc ggtcgctttt 770701 gttgattgga aaatcaacaa ccaaaaggga aagaaatatg cctacgatca tatgatcaag 770761 caggcgcacc cgggagccat ttacctgctt cacaccgtat cgagggacaa tgcagaagcg 770821 ctggatgacg cgattacaga tctgaaaaaa cagggctaca cttttaaaag cattgatgat 770881 ctgatgtttg agaaagaaat gaggctgccg tctttgtaaa agagaaagac ctctccttaa 770941 acggagaggc ttttctttat tttatacatt taatcagtgc ggcccagtcc agatccccga 771001 agcctttctc aatcccgctt tcaaaatggc tcttggccag ctcggcaaga ggaagatttg 771061 cagaaacccg ttttgcggcg gcgagtgcca ggttggtatc cttcagccct aaagacattt 771121 tgaagccggc cggctcaaat ttctgctcgg ccataatggt tccgtaattt tgatagactg 771181 gagaaccaaa gagcgcgctg gcgatttcta aaaattgttt ttgttctaag ccgtatttct 771241 ccatcattaa aaaggattca gataacgcct ccagcatgga cacaagcaag aaattaatgc 771301 tgattttggc tgcatttgcc gtcttgcttt cttcgccgac gtcaaatatc tgctggctca 771361 ggctgtcgag cagaggcttg gcagcttgct ttgcttccgc cggtccggct gttatgatac 771421 ggagcgcggc tttggctgcg gcatccggtc tgccaaggac aggagcggcg agaaaaaatt 771481 gtcctttctc tgcatgagcc gctgcgagct tttctgagaa ctcaacactg attgtgctca 771541 tcgagatgtg tatgccgttc tctgctaatc cttcaagcag cccgtcttct ccgaatgtca 771601 cggtgctgac agaatcatca tctgcaagca ttgtgatgac aatatcagcg gactttgccg 771661 ccagccgcgg cgtatcagct gcctgtgcgc cttctgtgac aaggtcttct gtcttttgtt 771721 tcgtccggtt atagacagtc aattcgtagc ctgcttgaag aacatttcgg gcaatgggct 771781 gtcccatatt gccgagtccg atgacagcaa ttttcaatct aatcactccc tgaatatttt 771841 ttccattata aacaatatga acagaatatg catagcgatc ggcttacaac aaaaaagaac 771901 agctgctcgc tgtcctcatt taaaaatatt gaaccatcct ttatgtacaa accaaatcag 771961 cattccaatc acaagcgcgg ccatcaggcc aagtacagcg aaatatccgt atttccaatg 772021 cagctccggc ataaagtcga agttcatacc gtatacaccg gcaataaagg tgagcgggat 772081 gaaaatggtt gatacgatcg tcagtgtcat cataatcgca ttcatccggt ttgagtttag 772141 cgtcacgtag ctgtcacgca agtcggacgt catgtcacgg ttggattcca caatttcaga 772201 caactttaac aaatgatcat atatgtcgct gaaataggct ttcgtttccc gctgctcttt 772261 cacatggtca aggcttaaaa tccggtagag caaatcacgc atcgggataa tcgtccgtct 772321 caaatgcaat aggtctgttc tgagatcaaa cacctcgttc atcagcgttc catacgtttt 772381 gtggggacgg ctttcttcaa tttcattcag ccggtcttca attttataca cgagaggaaa 772441 atattcatca acaagctgat ccatgatcat ataagaaata tgcccgggcc cttttttcaa 772501 tatgtccggt gaagcataca aacgctcccg gactttagcg ataccgggcg tttcgtgtaa 772561 atgaaaggtg acgacaaatt tttcgccttg aaagatatcg acttcctccg tctcaagtgt 772621 ttccttattc agcgcatgaa tcacgtaaaa acgatagccg tcataatggt caagctttgg 772681 ccgctgcata tgctggaagc aatcctcaat ggcaagcggg tgaaaatgaa aaaaatctct 772741 caataacgcc gtttccgtat cctccgggcc gtaaaaatca acccagtacc atgcaatatc 772801 aggctgttcc actcgttcga tcggtatatt tttcagcagc tgatgctctg ttgtgattgc 772861 ggtaatgttg atcataaaca accctccacc tgccattata tcatgcggtc tttatgagaa 772921 aagtatacgg tactctctgc ctaattccag cggcatgtta tactgaacaa aaacggaaaa 772981 aagggtggat ctcatgtgga aggaaaaagt atctgtcacg cctccgtatc attttgaccg 773041 cgtgctggac aggctgtctt tagaccccct caatgctgtt gatcgagagg cgagggaagt 773101 ccgtgtgcca atcagaaatc aagcggggga cgtatgtatt gtaaaggtac aggcgttagg 773161 ccatgcgggc gagcctgagt tcctcgtcag cggggaaacg gatcagggag aaatgatgaa 773221 ggaaatcaag cggatttttc aatgggaaaa tcatttgcag cacgttctgg atcatttttc 773281 aaaaacgagc ctgtccgcca tttttgaaga gcatgccggg acgccgcttg ttctggacta 773341 cagcgtgtac aactgcatga tgaaatgcat tatccaccag cagcttaatc tttccttcgc 773401 ttacacgcta acagaacggt ttgttcatgc gtttggcgag cagaaggatg gcgtgtggtg 773461 ctatccaaag ccggaaacga ttgcggaact cgattatcag gatctgcgtg atctgcaatt 773521 cagcatgaga aaagcggaat acaccattga tacatcaagg atgatcgcag aaggcacact 773581 cagcttgtca gagctgccgc atatggcgga tgaagacatt atgaagaaac tgatcaaaat 773641 caggggtatc ggcccgtgga ccgtgcaaaa cgtcctcatg ttcggacttg gccgtcccaa 773701 tttattcccg cttgccgata tcggcctcca gaatgccatc aaacgccact ttcagctgga 773761 cgataagccg gcaaaggatg tcatgctggc gatgagcaag gagtgggagc cttatttaag 773821 ctatgcgtct ttgtatttgt ggaggagtat agaataattc gtctgacaat gaaggaaatc 773881 ctgcaaacgt gttatactag aaagatgtga aaaaaccatt tcactttctg ccatccgcag 773941 aaagcttcat atagaaacgg agagaacaac gtgaaccaac aaaagaaaca ggcgcccgtc 774001 gaactgaagg tcggacaaac ttttccgctg acgattaagc gtctcggcat taacggagaa 774061 ggtgttggct attttaagaa aaaagtcgtc ttcgtgcccg gcgcgcttcc tggcgaagaa 774121 gttgttgtgc aggccacaaa ggtccagccg aagttttcgg agggccgcat taagaaaatc 774181 cgcaaggcat ctgagcaccg ggtggcaccg ccttgccctg tttatgaaca atgcggcggc 774241 tgtcagcttc agcaccttgc atacagccag cagcttcggg aaaaacgtga tatcgtcatt 774301 cagtctcttg aacgccatac gaagtttaaa gttgaaaaca tggaaatcaa agaaacgatt 774361 ggcatggaca acccgtggaa ttaccgcaat aaaagccaat tccagatcgg gcgctcgcaa 774421 agcggcagca tcatcgccgg cttatacggc cttgattctc atgatatcgt gccgattaaa 774481 gactgtatcg ttcagcatcc ggcaacgaac aaaacaacag gcatcgtccg ccgcatttta 774541 gaggacttca atgtgtctgt ttataatgaa agaaaacgaa aaggcgacgt tcgcacgatc 774601 gtgacgagag tcggctttga aacaggcgaa gtgcaggtcg tgcttgtaac cgcaaaagaa 774661 acgcttccgc acaaggaaga aatcgtcaaa gcgattcaaa agcgattgcc agaggtcaaa 774721 tccattattc agaatgtaaa cggggcgaaa acctcagtga tttttggtga gaaaacaaaa 774781 cagctcgccg gaaaaacagt gattcaagaa gtgctcggcg acgtatcttt tgaattgagc 774841 gcccgcgctt tcttccagct caatccggaa cagaccgtca agctgtatga tgaagtgaaa 774901 aaagcggcgc agctgaccgg aaaagaaaaa gtcgttgatg cgtattgcgg cgtcggcact 774961 atcggcatgt gggttgcgga cggagcgaag gaagtccgcg gcatggacgt catcaaggaa 775021 tcaattgacg atgctaagaa aaacgccaaa aaacacggca tggcaaatgc cacatacgta 775081 acaggaacag ccgagcactg gctcccgaaa tggacgaaag aaggcttccg cccggacgtc 775141 gtcattgtag acccgccaag aacgggctgt gacagcacgt tcttggacac gatcaaaaaa 775201 gtcaaaccga aacgctttgt ctacgtttcc tgcaatccat ccacgcttgc gaaagatttg 775261 cagacgctgt cgaaggacta tcgcgtggac tatattcagc ctgtcgatat gtttccgcag 775321 acggcgcatg ttgaagcagt ggcgaggctt gtattaaaat cgtctaacta aaaagaacat 775381 ttcccagtca taaaatagtt ttcctaataa gacctggatt tcggtaaaat aaacaattcc 775441 gatttccggg tctttttcgt gcgcagctct tgtcctaacg gtctgttctc aattttatct 775501 tccttctttt cgcggagatc tttattttaa ctggcgaaaa gaattgaaaa aacgtgttga 775561 aaagcaggtg aaaaaaagcg ttatttaacc ggaaaaatat cctcccagta tgtttaaaat 775621 acatgagtag aatgatgtaa aatcatagat gtattttcat aatttgtaaa attatatatt 775681 gacttgcagt tattacgtgt gaaatattga tgataggaat ataaggaaag tatggcgtat 775741 atcatttcaa gagtcattcg atgtaaaaag ttgaaacatt gtaataaatg aaagaggtga 775801 aaatgatggc caaccccatt ttaaaatgca taacgtatga gcactacaac aattaaataa 775861 tagtgccgag acgataacaa ctattacagt aatacctaca atggttatat ccttgcgaca 775921 atcatgcttc ataatataat gattttagat tgacacttgg ctaaaaagta ttgcagagaa 775981 ggaaatggat aattaaatgg ataaagtata taaaagaagt tggtttcaaa catttttggc 776041 atttttagta tctcagcttt attttaattt tgtagaatta acgggatggg gtcctaagta 776101 tagagaaatg aatggattcc cagcaaacat agttgaacta gatttctttc aaacatatct 776161 ttcattctat gataatccat ggtttaatat tattactgtt ttcttgggag ttttcactat 776221 tatacaaata attacaggga taacaaagga tattcgaaat taaagcaata acttctgatg 776281 ccttatttaa tgatgaaaga aaatgtacac tttcttaatt atcttatgag tgaagactgc 776341 gacacttagt cagcagtcta ttttatggtt ctggatcagg attaccgaat tataacccta 776401 tacaaatata tagtaggttg ccacttgctg cgttggttat tttctaaatc atgagcaaat 776461 cccaaatgat tcagattgaa gttcttgaat tcttttaaat aagggtttat tttctcttct 776521 catcctcttt actccatgtg attcacaagt ggtagcagct taagtaggtt ttttcattct 776581 cttgagtact cagttatacc acccccaact caatttgctt tatctctatt agtttttccg 776641 caaatatgat atagagatac ggatatggtg tagtgttaaa tatcttatct tcaataacag 776701 ggcaattatt ttgcgttggt aatatggaga actcatatga tattctattt aggttggaat 776761 cctttttatc caaaaagttc aaaagcaagg ccactaagaa agacgaaggt cagcgccagt 776821 taaccagaat ataaaaaata gggtagataa tcatcccacg tgaaatcttc aaaatttact 776881 atagattgat aagaaatgct ttcgcatgcg ataagtgtaa aagaagcatg gtcagttttt 776941 aatttgggat aaaggttcag ccgtatccca taatgaaagg atttgatttt tgttatgaca 777001 gaaaatttct ggcgtgaatt accacggccg ttttttgtac tggcaccaat ggaagatgtg 777061 acagatgttg ttttccggca tgtagtaagt gaagcaggca gaccggatgt gttttttaca 777121 gagttcacaa actcagagag ctattgccac ccggatggga aggatagcgt gcgcggccgt 777181 ttgactttta cagaggatga acagccaatt gtggcccata tatggggaga taagcctgaa 777241 aacttccgta aaatgagtat tggcatggca gagttaggat ttaaaggact agatatcaat 777301 atgggctgcc ctgtgcctaa tgtggcgggg aatggaaagg gaagcggcct tatttgccgt 777361 cctgcagttg cggcagaatt aatacaagct gcaaaagcag ggggattgcc tgtaagcgtg 777421 aagacaagac ttggatacac ggatgtggat gaatggcgcg agtggctgac acacattttg 777481 aaacaggata ttgcgaatct ttctattcat ctgcgtacaa gggcagaaat gagcaaagta 777541 gatgcgcatt gggagctcat cccagagatt aagaaacttc gtgacgaggt ggcaccagat 777601 acattgctaa caataaacgg ggatattcct gaccgtcaaa ctggcttgaa acttgctgaa 777661 caatacggcg tcgatggaat tatgataggg cgcggtattt ttacaaatcc tttcgctttt 777721 gaaaaggagc cgaaagagca tagcagcaag gaattgcttg atctcttaag gctgcatctg 777781 gatctccatg atgaatattc aaaagaagaa gcccgtccat acaagcctct tcctcgcttt 777841 ttcaagattt atctccgcgg attccgaggg gcaagtgaat taagaaatca atgcatgaac 777901 acaaagtcaa cagatgaagt gcgtgcattg ctcgacgact ttgagagaaa gtatcttgat 777961 gggatagagt aacagcagtg cttgattcaa aaaaggctaa caaaataaag ggatttttac 778021 acaattcttg actaaaataa acctggattt tcggtaaatc cgggtctttt ttgtacgcag 778081 cttttactca gcctgtcttt tctctaattt attgtaagaa aataatggta tatttagtgg 778141 agatatcata taaaggggga gaggaaaatg aaacggctat gcatcatccc ctgcggcaag 778201 aaaaaaatct gggatgtcca gcctgatgcc gggccggtaa gagcagagga cgcttatctc 778261 agcccgtttc atcaggcgtg cgagcggtat gcaaaaacat ttttcgatga gtgggtgatt 778321 ttgtcggcga agcacgggtt cctccgccct gatgatctcg tttcgggaaa ttacgatgtc 778381 acttttggca ccggtcatcc ggaaatcatg acagcggacg agctgcgccg tcaatttcac 778441 gaaaaaggct tttctgatat cgaagagcta gtcatgcttg gcggaaaaaa atatcgaagc 778501 gttctaaacg ccgtcatcgg agaacaccag catatcagct ggccgctatc atcatacaaa 778561 ggcataggct atatgctcca agcgctgaac cgggctgttg aagaaaagca tgaactgtag 778621 cacgtacata tgaggaaaag agtgggaaca tgaaaaaact tgtgtttggc ttgcttgcca 778681 ttgtgttatt cggatgcgga ctatatatct atcatgtatg gttcggtgat ccattttcga 778741 aaaatgctgc agaacagaag ctagtgtctt atgtgaaaca aacctatcct aagaaagaaa 778801 tcaagatcac gaatggggta tataacgcta aaacgtctga atatgtattt gaagcaacct 778861 cccaatctca tcgctaccca atgtgtacga agggatttct gcatcctaaa gtaacgtgcg 778921 atggaattga agaagcgtat accgaatcag tagcaaaaca tgtaaatgaa gaagcaacga 778981 aggcaatcga agcagatctg aaaaaagcgg ttcctcgatt tataaaagct gatgctgctt 779041 tgagtatcga aaacggacag ttcacgttag atacaaaatg gaacaaaaag ctggctgaaa 779101 aagcgcctat gagcatgacg attcagttag acgccagcgg gttatcaaaa acagatgccg 779161 caaagatggc ggaaacggtc agaaaaacgc ttaatgaaaa gggatataca tactcaaacg 779221 gcacgataga ctgtatgcag aaggacgggg acggcggtat tggatatgtc aaatattcaa 779281 ttgattttct ttcaaaagca gctattcagt caaacgatgc agaggaacta ggaagttaaa 779341 aagatttcca aggaaataaa tacgtcgatc attgtcaaag gccgggtgat atccggtctt 779401 ttttttgcat gctgtaaaac gagacaaatg aatcagtttg agacaaaacg agacacacgt 779461 ctcaaactgt ctccaaagtg aagatgagaa gactgatttt acgggctcaa aagactggca 779521 cacttcttgc atttataatg gtgaacccta aatagaagga ggcgcacaaa atgaaattgt 779581 taaaacgaga aggcttgtca ttaactgagg aaaaagcgct gtggatgtac caaaagatgc 779641 tggagatcag gggctttgaa gacaaagtgc atgaactgtt cgcccaggga gtgcttcccg 779701 gattcgttca tttatatgcc ggtgaggaag ccgtggctgt aggggtgtgc gctcatttac 779761 atgatggcga cagcattaca agcacccaca ggggacatgg acattgtatc gccaaaggct 779821 gtgacctgga cggcatgatg gcggaaattt tcgggaaagc gaccggattg tgcaaaggca 779881 agggcggttc tatgcacatt gcggatcttg ataaaggcat gttaggcgca aatggaatcg 779941 tcgggggcgg ctttacgctc gcatgcggat cagcgctcac ggctaaatat aaacagacta 780001 aaaatgtaag cgtttgcttt ttcggggacg gggcaaataa ccaaggtacc ttccacgaag 780061 ggctgaattt agcggctgta tggaaccttc ctgtcgtatt tgttgctgaa aacaacggct 780121 atggcgaagc taccccattt gagtacgcat cagcctgtga ttcaatcgcc gatcgggcgg 780181 ctgcttataa catgccgggg gttacagttg acggcaaaga tattttagca gtttaccagg 780241 cagccgagga agcgatagaa agagcaagaa acggcggcgg cccgtctttg attgaatgta 780301 tgacctacag aaactacggc catttcgaag gagatgccca aacctataaa acgaaggatg 780361 aaagagttga gcaccttgaa gaaaaagatg ccattcaagg ttttaaaaac taccttttaa 780421 aagaaacaga tgctaataag ctgtcagaca ttgaacagcg tgtcagcgaa tcgattgaaa 780481 aagccgtctc gttcagcgaa gacagcccat atccaaaaga ttcggagctg ctgacagatg 780541 tgtatgtgtc atatgaaaaa ggaggaatgt aagagatggc gagagtcata agcatgtcag 780601 acgcgatcaa tgaagcaatg aagcttgcga tgagaaaaga cgaaaatgtg cttttgatcg 780661 gtgaggatgt cgccggggga gcggcggtcg atcatttgca ggatgatgaa gcatggggcg 780721 gtgtattagg ggtcacaaag ggactcgtac aggaattcgg gcgtacaaga gtgctggaca 780781 ctccgatttc tgaggcaggc tatatgggag cggctatggc tgcggcatca accggtttga 780841 gaccgattgc cgagctgatg tttaacgatt ttatcggcac gtgctttgat caggtgatca 780901 accaaggggc gaaattccgt tatatgttcg gcggaaaagc gcaagtgccg attaccgtcc 780961 gcaccacata cggagcaggg ttccgggccg ctgcccagca ttcacaatcg ctgtatggcc 781021 ttttcacgag catccctgga ctgaagacag ttgttccatc caatccgtat gatgccaaag 781081 gtcttttgct tgcagcaata gaagataatg atccggtgtt tttctttgaa gacaaaacgt 781141 cctacaacat gaagggcgag gtgccggaag attattatac aattcccctc ggaaaagcgg 781201 atatcaaacg cgaaggcaat gatgttacgc tctttgcagt cggcaagcag gtcaatactg 781261 cgcttgaagc ggctgcacag ctttcagaga ggggcatcga agccgaggtc cttgatcccc 781321 gcagtctgtc tcctctggat gaggatgcga ttttcacatc gttagaaaaa acaaaccggc 781381 tgatcatcat tgatgaagcc aatccgcgat gcagcattgc cacggatatt gctgcgcttg 781441 tcgctgacaa gggctttgat ttgcttgatg cgccgattaa acggattaca gcgccgcata 781501 caccggttcc gttttcacca gtgcttgaag atcaatattt gccgacacca gataaaattg 781561 tcagcgtcac gcttgaattg cttggcgagc cggcattgaa ttaaaggggg gacacaaatg 781621 gcggtaaaag tagtgatgcc aaaattggga atggccatga aacaagggga agtatcgata 781681 tggaataaaa aagtaggcga cccggttgaa aagggagaaa gcattgccag cattcaatcg 781741 gagaaaattg aaatggagat cgaagcgcct gaaaaaggaa cgctgatcga tatcaaagtg 781801 aaagagggag aagaggttcc gcccggcaca gctatctgct atatcgggga cgccaatgag 781861 tcggtgcagg aagaggcggg ggcgcctgtt gctgaagaca atatgccgca agccgtccag 781921 cccgtcaaac aagaaaacaa acccgcagcc tccaaaaaag atcgaatgaa aatatctcca 781981 gtcgccagga aaatagcaga aaaagcagga ttagacctaa aacaactgaa aggaactgga 782041 ccaggcggac gaatcgtgaa ggatgacgta acaaaggctc ttgctgaaca gaaaaaagat 782101 caagcaaagc ctgtttcgga gcagaaagcg caggaaatcc cggtgacagg catgagaaag 782161 gtcatcgctg cccgaatgca ggaaagcctg gcaaacagcg cgcagctgac gatcacgatg 782221 aaagctgata tcaccaagct tgccactctt caaaaacagc tttcaccaac tgcggaagag 782281 agatacggca caaaactgac gatcactcat tttgtctcaa gagccgccgt tctcgctctg 782341 caagctcacc ctgtgctgaa cagcttttat caaaatgagc gcatcatcac acatccccat 782401 gtgcaccttg gtatggctgt agccttggaa aatggcttag tggtgcctgt catccgccat 782461 gctgaaaagc tatcgctgat tgaactggct caatccatct cagaaaatgc caaaaaagca 782521 cgcgagggac gtgcgggaag cgaagaactg caaggatcta ctttctccat tacaaacctt 782581 ggcgcgtttg gagttgagca tttcacaccg atactaaatc cgccggaaac aggcattctc 782641 ggcatcggag caagctatga cacaccggtg tatcaagggg aggagatcgt cagaagcacg 782701 atcctgccac tcagcctgac atttgatcac agagcgtgtg acggcgcccc tgccgctgca 782761 ttcctgaagg cgatgaaaac atatttggaa gaacccgcag cattaatttt ataggaaaag 782821 caggtgaaaa cgacatgaca ttagccatta tcggcggcgg acctgcaggc tatgcggctg 782881 cggtttccgc ggcacagcag ggcagaaacg tgctgctcat tgacaaaggc aagcttgggg 782941 ggacctgcct gaatgaaggc tgcatcccga caaagtcttt gttagaaagc gcaaacgttc 783001 ttgataaaat caagcatgcc gacagctttg gaatcgaact tccggcaggt gcgatatcag 783061 tcgattggag taaaatgcaa agccgaaaac aacaggttgt cagtcagctt gtccaaggcg 783121 ttcagtacct aatgaagaaa aatcaaatac aggttgtaaa gggaacagcc tcctttcttt 783181 ctgaaagaaa gctcttgatc gaaggagaaa acggaaaaga aatcagagag gcggaccaag 783241 tattgattgc ctccgggtca gagccaatcg agctgccttt tgccccattt gacggcgaat 783301 ggatcctcga cagcaaagac gcgctttctc tttccgagat tccgtcttca ctagtcattg 783361 tcggcggcgg tgtcatcggg tgtgagtatg cagggctgtt cgccagattg ggatcgcagg 783421 tgaccatcat tgaaacagcg gaccggctga tcccggctga agatgaagat attgcccgtc 783481 tctttcagga gaaacttgag gaagacggtg tcgaagtgca tacttcatcc agattagggc 783541 gggtggatca aacggccaaa acggcaatat ggaaaagcgg tcagcgagag tttaaaacga 783601 aggccgatta tgtgctggtg gcgatcggca gaaaaccccg tcttgacgga ttgcagctgg 783661 aacaggccgg agttgatttt tctccaaagg gcattccggt gaatgggcac atgcagacga 783721 acgtgcctca tatttacgcg tgcggagatg ctataggggg cattcagctc gcgcatgccg 783781 ctttccatga gggcatcatc gctgcttctc atgcttccgg aagggatgtc aaaatcaatg 783841 agaaacatgt gccgcgctgc atctatacgt ccccggaaat cgcgtgtatc ggaatgacag 783901 aacgacaggc aagaagcata tacggggatg tgaagatcgg cgaattttca ttttccgcaa 783961 acggcaaggc gctcattaaa cagcaagcgg aaggaaaggt caaaatcatg gctgaaccgg 784021 aattcggcga aatcgtgggt gtctcgatga ttggcccgga tgtaaccgag ctcatcggcc 784081 aagcggcagc gatcatgaat ggtgagatga cggcagatat ggcggagcat tttatcgccg 784141 cccatccgac tttatcggaa acattgcatg aggcgctgtt aagcacgatc ggccttgcgg 784201 tacatgcata ataaaggaaa aagcaggcgc atggatataa ggcgcctgct tttttattgt 784261 tgaaagcgct ttatttttcc cctacaatag atgaaaacgg cgtgtaaggg aggagcgatc 784321 aaggaaatga attcggtccc aaacgatttg caaacctgga aacgttttgt gaaagacggt 784381 gtgcttgacg aagcccgatt aagaaaacgg attgcagagt catggcatcg ctgcaaaaaa 784441 gctgaggtca atccttattt agaaaaaggc ccgaaggttt tacagcaaac ggagctggat 784501 cagcagtcaa aaaaacattc attcttcttg acgaccgcaa agccttacct cgaaaaactg 784561 ctgcctgcca taaaagaaat ggaaatgatg gcgctgttaa ttgattcaga cggtgttgtt 784621 ctggcattgg acggccatcc gcgcgcgctc tatgaagcca aacgcatcaa tttcgtcgaa 784681 ggggcatgct ggacagaaac ggctgtcgga acaaatgcga ttggcacggc gctccacatc 784741 agcgagccgg ttgcaataca aggatcagag cattactcta tcgcttccca tctttggaac 784801 tgttcagctg ctccgattca ccatgaggat ggcagccttg cgggtgtaat tgacatatca 784861 tgcccggcgg caggcgcgca tcctcatatg cttggtattg ccacggcgat tgcctatgcc 784921 gctgaacggg aactcgcagc taaaagccgt gagaaagagc tggagctgat cagccgtttt 784981 ggggagagag ctgcatccag tgtgccgatg gtgctctgta ataccaagca gcacatcatc 785041 agtgcgagca tgccgattcg aacctcaatg ccggattggc agggccggca cctgtacgag 785101 ttgaaggaac ggggctattc aatcgaaaat gctgtcacca taggagatgg cggcacttgt 785161 ttttatcttt cggaacaaaa gaaaaagaag gcgtttcgat tcaatggagt gatcgggcaa 785221 agcggccgat cgcaagcgat gctgatgcac cttgaacgag cagctgcgac ggatgcatcg 785281 gtctgtttgt cgggtgaaac gggtacgggg aaggaggtcg cggctcgcgc gcttcatgag 785341 aacagtgaga gacggcacgg tccgtttgtt gctgtcaatt gcggagcgat tccgtctgat 785401 ttgattgaaa gcgaactgtt cggatatgca gagggcgctt ttacgggagc gaaacgaaat 785461 ggctataaag gcgcctttca aaaagcgaat caaggcacat tatttttaga tgaaatcgga 785521 gaaatttccc actcgatgca ggttgcactt ttacgggtgc ttcaggaacg caagataacg 785581 ccaatcggcg ggacgaaaga aattccggtt gatatcagag ttattgccgc cacacattgt 785641 gatttacgcg agcttgccga aaacggaaaa atcagagagg acttgtttta ccgtcttcat 785701 gtctatccaa ttgaactccc tccattacgc gatcgcaccg aggatatccc ggatctcttt 785761 gagtactaca aacagaagaa tcattggcca ggcgatcttc cttctgattt ttgtaatgtg 785821 ctgaagcaat ggaagtggcc ggggaatatc cgcgagctgt ttaatgtgtt tgaacgtctt 785881 tctatcagat ttccggacgg ccggctgaga gatgaatcgc ttcccgcttt actggaagcc 785941 gctggattgc cggccagctc tgcagaaaaa aagccggctg ctgccggcgt gcttactttt 786001 cgtgagcaaa tccaaaagga tatgatgatc aaagcgcttg aatctgcaaa aggaaacgtc 786061 tctcaagccg caaaaatcag cgggatcccc cgaagcactt tctacaaacg cctgaaaaaa 786121 ttcaacttgt ccgctgaatc ataaagcata cttccttcag gaaatggaaa cgttatgtat 786181 tgaaggaggg tgttacgatg aatattcaaa gggcgaaaga aattgtagaa tctcccgaca 786241 tgaagaaagt aacatataac ggcgttccta tttacattca gcacgtaaat gaagaaactg 786301 gaacagcaag aatttatccg cttgacgaac cgcaagagga gcatgaagtg cagctgaaca 786361 gcttaaaaga ggattaaaca aaaatggccc gcttcataag caggccattt tgttatccgc 786421 gcggcgcaaa taaaataaca cagacaccga tgagacaaat gaatgcgccg atccagtcat 786481 acagatcagg tgttttccgg tcaacaagcc atccccacag gaccgcaagc acgatgaata 786541 ctccgccata agcggcgtat acacggccga aagatgggaa ggactgaaac gtcggaagaa 786601 tgccgtatac aatgaggatc agcgccccgg cgattccgta gccagctggc tttgcctctc 786661 tcagccatag ccaaaccaga tatccgccgc caatttcagc aagccctgcc gcgagaaata 786721 aaagaatggt aatcagcatc atgagcactc ctcaatttgc atttatcttt cattatagag 786781 gaggagagct tttaaagctt cggatgattc tcaaattcct tcaaatacgc ttttcgctga 786841 acctctgtaa attggctgat ccaattgttt tgagcctctt cattcaaatg gggaaggata 786901 tagcgttcaa ccgcttcgaa aaacagcgga ttcgtgatga tgttccaggt cgggattcga 786961 acgattttgc cgtctgtttt ctcgatgata atatcctcaa aaaagatccc tttcaaactg 787021 tattgatggc gtcccatata aagccgcttc acctcggaaa acagcacgct gcgctttctc 787081 aagaagattt cgccactagg tccggtcttt atggtgaaaa tgacatttcc acggcttgtg 787141 aacgcaggaa aagccataaa gaatgtgatc aatccataaa tcatcgccag taatccgccg 787201 cccaaataaa gcagggcata tttagattca aacgtgaggg cttcagacac cagccagact 787261 cccacaataa aggcgccccc tgtagcgagg aacagccaag cccttagaaa catcatgctt 787321 tttacttcaa tcatgtgctg cccctaaagc ttcggatgat tctcaaattc cttcaaatac 787381 gcactgcgtt ggatgtctgt aaactgtccg atccaattgc ttttcgcctc ttcattcaga 787441 tgtggaagga tatagcgttc aaccgcttcg aaaaacaacg gattcggaat gatgttccaa 787501 gtgggaatgc gaatggtctt ctgatccacg gtttggatca atatatcttc ttggaagatt 787561 ccttttagac taaatttatg gcggctcatc tcaattttct tgatatcagt aaacgtaaca 787621 gacactttgt cagtgaacac ttctccattt tttcctgtct tgatgcggaa aatggtattt 787681 ccccgcgggg tgaaagccgg aaagaagatg ataaataaat ataaacaaaa caaggtgaac 787741 agaaagccag caggaatggc taataggtaa tatttcgttt gaaacgtaat acccatataa 787801 aagagccaca aacatgctaa tcccataccg gcagatccga caaaagccca tattctcagg 787861 aacattttgc ttttgacttc aatgatttct tggtttttca atgcttttct ccttttgtta 787921 attcaattct tatcattttg aaatgatttg atttacaaca tccttatgag cagggaggat 787981 agaaaattca ttctgggtga tgcctgtgac aagccaagta tggtgggccc ccggcaggac 788041 gaatgccatg tcagccactt caggagtgtt atcttttcca tatgccagac gcataagtgt 788101 atccattttc cctttccgca aagccagatc atttgcaaat cgggtaacgt cctcttggtg 788161 gtcatgtttt tcaaggaact cttttagata tgaagggttg tctgaagcgc cctccaagag 788221 tttttcaaat tcatttgatg tcaatgttac aatcgattct cttttatcct ctgtatctat 788281 tatatgtaaa aactcatctg tcttagcaag taacccttca cttgattcca tttttgtaat 788341 gcgatggact tgttcatcaa aaaggagttc gtgagagtag gtgccgaatt ttgatacatg 788401 gcatgacaca ttctgttcgg caccttgccc gttaaattta gaaagcttca ctgtatagtc 788461 agcgtcgttt aatacatgga taaacggaca gtactcgtcc tttaaccgat attgatggtt 788521 ccgatattcc gctgcatcct tggctaagag tgagcggcac gcggcttcaa ataaggcgcc 788581 gagctgttca tcttctattt ccggaaaata ggcctgcttc aaggccattc cctgttcaaa 788641 aaacccttcg ctgtaaaagc aaaacaagag ttcttctatg ctaattgtaa actgcttcat 788701 tgtttattct cctatccaaa tgaaaatttc cctttaagga aatgggttgc gccgtgtata 788761 agcgaatccg ctgttttctt tgctttttcc attccttttt tcgcgctgtc tatcccttta 788821 tgtatcgatt tattcgccgc atctatgccg tcattcactg atttgacgac tttgccggct 788881 gattccagcc cttttttggc tgtatcaaca acagcatgga tcggttcttt cagctttaag 788941 gctgcttttt cagcaaaacc ggctgtatat ttggcgattt gttctccgac gactccgcca 789001 atgtatgaac ctgctgcccc aagaaggaca gtacccacag gtcctgcaaa gcttccgatt 789061 gcaccgccga tgacagcacc agctgtggca ccgccggcaa caaaaatcgt attattcaca 789121 gcattcccga cggccttggc gttttcacgc ttgagaactt ccggtttatc ctggtatttt 789181 gcataatttt cagcaatttt cacgcctgct ccgaatgttt cggtcgctcc ggtaatcagt 789241 gtggcggtaa tggcatttcc tttcgcgaat ctcaagcccg tttttcccac atccttcaaa 789301 gtggagcgta cgccggcttc attaagaaat ccttttgtgt agcttctgac gctgtttgaa 789361 aaatccaccg tgtcctgagg aaagtatttt gtaaactttt tatgtaccaa atctgaaaat 789421 ggacggtttg tctttttcaa caaatattta ggattcaaaa gcactcttgc cgctttttga 789481 taacgtgagc tgtcaacggc cctggaaata tccaagagca gttttgagtg ctgggctgta 789541 tgcaagccgc ttggttgttt cacaaatttc gtaagcccta atccgtaata ttttccctgc 789601 gtcagcataa gagcggttaa gcttgtcatc gtaccgtatt tgtcgtaggc attgtagagc 789661 tttcgcaaaa tatcatcttg ttccacaaat ttatcgcctg tttttctgat gaaaatctca 789721 ttgtcactca gcttagtgac gagcgccttt cctgagctcc acgcatcgcc cactccagaa 789781 aaacagctgc tgtagcgggg atcgcattgc aaaatcatct gccccagctc cacatgcagg 789841 tccttatatt tgttttccat atcagttaat tcagtgacta catcatttgc aagctgttcg 789901 agcttatccg gatcaactgc aatgtttcct gacacaccgt tcacctcccg agtttatgtc 789961 tttcctctct tgctttacgc tccagttctt ccattctggc aatttcagct tttcgttctt 790021 ctattttgac agcggcagcc ttcagctctt ggcttgtttc aagcagctcc tgttcgaatt 790081 gatcgtaggc ggctttcgtt tcctcgaaat cctggtcaaa cgaatctctt gctttgccct 790141 gccaagcatc tcccaatgca gataaccggg attcaagcag cattttggag cttctgacct 790201 cttctgcggc cgcactatac ttgtttgcca gctcaatgac tttatatgag tccaactttt 790261 gtcccctgcc ttttctaaat tcacgcacaa ttggatgttt tatataaatg attataaata 790321 attcggcatg tatccgaatc gtacaaaaga accttttcat aagaattgga agggcgtata 790381 ttcacttaaa attcacagtt ggtgagactt taagattaca aaaaaggtaa aaaaaccaaa 790441 tctctcagac ataaggcaaa tgagaaattt cccgctctat gggaaaaaac actaaagttg 790501 atcaaatgac ctaagtgcgc caaacgtgtt acgggacgag ctatctcatg gtataaatgg 790561 aattgtaaac gttatcaagg aggtcgtcat atgaagaaaa aatcattctc aatcgtaata 790621 gcgggcggag ggagcacttt cactccaggg atcgtactca tgctcttgga ccatttggag 790681 gagtttccga tcagaaagct gaagctgtat gataatgata aggagagaca ggatcgaatt 790741 gcaggcgcct gtgacgtttt tatcagagaa aaagcgccgg atattgaatt tgcagcgacg 790801 actgacccgg aagaagcttt tacagatgtc gattttgtta tggcgcacat cagagtaggg 790861 aaatacgcga tgcgcgcgct tgatgagcaa attccgttaa agtacggagt tgtcggccag 790921 gagacgtgcg ggccgggcgg gatcgcatac ggtatgcgtt cgatcggcgg tgtgcttgaa 790981 atattagatt acatggaaaa atactcgcct gatgcgtgga tgctcaatta ttccaatccg 791041 gcggcaattg tggctgaagc tacgagacgc cttagaccga attctaaaat tctcaatatc 791101 tgtgatatgc cggttgggat cgaagaccgg atggcgcaaa ttcttggctt atcctcaaga 791161 aaagaaatga aggtccgcta ttacggattg aatcatttcg gctggtggac atcgattcag 791221 gatcaagagg gcaacgattt aatgccgaag ctgaaggaac atgtatccca atacggttat 791281 attccgaaaa cagaggctga agctgtggag gcaagctgga atgacacgtt cgccaaagcg 791341 cgtgacgtgc aggctgcaga tcctgacaca ctgccgaata cgtatttgca atattatttg 791401 ttcccagatg atatggtgaa aaaatcaaat ccgaatcata cgcgggcgaa tgaagtcatg 791461 gaagggcgcg aagcttttat tttcagccaa tgtgacatga tcacacgtga acagtcctcg 791521 gaaaacagcg aaattaaaat cgatgaccac gcatcgtata tcgttgatct tgcccgggcg 791581 attgcctaca acacaggtga aagaatgctg ttgattgttg aaaataacgg tgcaattgcg 791641 aactttgacc cgactgcgat ggttgaggtg ccatgcatcg tcggctcaaa tggacctgaa 791701 ccgattaccg ttggcaccat tccgcaattc cagaaagggc tcatggagca gcaggtatcc 791761 gttgagaagc tgactgttga agcgtgggca gagaaatcgt tccaaaagct gtggcaggcg 791821 ctgatcctgt caaaaacagt gccgaacgcg cgtgtggcaa gactcattct tgaggattta 791881 gtggaggcca acaaagactt ctggcctgag cttgatcaaa gcccaacccg catatcataa 791941 atgaaattcc cccattttcg aatctgtaat tgtatataat agaaagaaaa tggggggatc 792001 tgatatgcag ctcgaagaac tgatcaatca gcactacagc aaattgaatg acaacgattt 792061 tcatatttta aaatatatat tgaatcataa gcacacatgc tatcaccttg gaatcgacgc 792121 gctggccaaa gcttgcagtg tatcgcgttc ctcaatttta cggcttgccc aaaagctcgg 792181 tttcagcggt tacagtgaat ttcgcgtctt tttaaagtgg gaagatcagc cggaagaagg 792241 cgagagtatg agttttgaaa agctgcttga tgatattgaa gcaaatttga agtttttacg 792301 gacaaaggac atgacggaca tgtgccagct gattgatgca gctgaccgca ttttcgtcta 792361 cggttctgga aatgcgcaaa agatatgcgc ccgcgacctg caaagaatgt ttattccgcg 792421 ccatcgctat cttattttga ttgaagacac aaatgaattt aatttgatgc gcgatgattt 792481 taaagtgaac gatctgttta tcatcatttc tctttccgga gaaacaccgg agctgattcc 792541 tcaggcaaga atgctttctg caaagggtat tccctttatt tccattacga atttaaaaaa 792601 caatgtcctc gcccagctga ctccgcataa tctttatgcg acaagcaaac ctgtgacatt 792661 aagcgataga acggaaattg tcgcttttgc accgtttttt ctcgttggcg aagcattgtt 792721 ccgcgcatat gttgattaca aagaggcaga aaaaaatgac aatgagtagc agggggttct 792781 ggtatgatgc aaaaaattca gcgctttgga agcgcgatgt ttgtgcctgt tttattattc 792841 gcgttcgccg gcattatcgt cggtatcagc acgctcttta aaaataaaac cctcatggga 792901 ccgctcgccg atcctgacgg tttttggtat cagtgctggt atatcattga gcagggcggc 792961 tggactgttt ttaaccaaat gccgctctta ttcgccattg gcatcccggt tgctttggcg 793021 aagaaagctc aggcacgcgc ctgtttggaa gcgcttactg tctacctgac attcaactat 793081 tttgtcagcg cgatattgac ggtatgggga ggagcatttg gcgtcgacat gaatcaagag 793141 gtcggcggaa cgagcgggtt aacgatgatt gcgggcataa aaacgctcga taccaacatc 793201 atcggagcca tctttatttc ttcgattgtc gtctttttgc ataatcgcta ttttgataaa 793261 aaactgcccg attttctcgg catctttcaa ggctcaacat atatcgtgat gatttccttc 793321 tttattatga tcccaattgc gttggctgtg tcttatattt ggccgatggt tcaatcggga 793381 atcggctcgc ttcaaagctt cctggttgct tctggggcgg tgggcgtttg gatatacacg 793441 tttttggaac ggattttaat tccgaccggc cttcatcact ttatttacac gccgtttatt 793501 tatggcccgg ctgtagcgga aggcgggatc gtcacgtatt gggcacagca tctcggcgaa 793561 tattcgcaaa gcgccaaacc gctgaaggag ctctttccgc aaggcggatt cgcgcttcac 793621 ggcaactcga aaatcttcgg tattccgggt atcgccctgg ctttttatgt gacagccaaa 793681 aaggaaaaga aaaaactcgt cgcagggctg ctgattcctg tcacactgac agcgattgtc 793741 gccggtatta cagagccgat tgagtttacg ttcttattca tttcaccttt cttatttgcg 793801 gttcacgccg tgcttgccgc cacaatgtcg acagttatgt atatggccgg cgtcgtcgga 793861 aatatgggag gcggactgat tgaggcggta accttgaact ggattccgct ctttggcagc 793921 cacggtatga catatgtgta tcaaattttg atcgggctct cgtttacagc aatttatttt 793981 ttcgtcttca gatttttaat cctcaaattc aatatcgcta caccaggacg ggaaaaggat 794041 gaacagcagg aaacaaagct atattcgaaa aaggaataca gagaacgaaa aaacaaggat 794101 gaaacggcct ccgctgctga aacggctgat gacaccgctt ttctgtatat tgaagcgctg 794161 ggcggaaaag acaacatcac tgaagtcaca aactgcgcca cccgcctcag agtcagtgtc 794221 aaggatgaaa caaaggttga acccgacagc gtattccgcg cgcttggcgc acacggcgtt 794281 gtcaggaacg ggaaggcgtt tcaggtaatt atcggattaa gcgtgccgca gatgcgggag 794341 cgtgtggaaa aaatattgaa tcaataaaga ctgccctcct tttcgggagg gttttcgttt 794401 gccgtcaaaa agaccgccat agtaaagtaa agaaagagac aatcgagtaa aaaggggttt 794461 ggaggctttt acatgcaaaa ggctttgtcg tttttaaaac catattcatt gctggcggga 794521 attgctctga ttcttatgct gacggagctt gcagttgaac tgatgcagcc tttattgatt 794581 gcaaaaatca tcgacgatgg gatattgaag caagatctgc ggcatgtatg gatatggggc 794641 acggtcatga tcgggctgac cgtgttatcc tttgcggcgg ggatgctgaa ttccttttat 794701 gccgcccatg tcagccaaag cttttcctat gatacgagaa aagggctttt tcaaaaaatc 794761 cagtccttct cctattccac atttggacag ttttcgtcct cttcttatat tacaaggctg 794821 acaaacgacg tcacacaggt tcaaaatatg atttttatga gtttgcggtt tatgctgcgg 794881 gctcccttaa tgattgcagg cggcattgtg ctgtcgcttg ccgttaatgt gaaactcggg 794941 ttttttctgc ttgtgaccat tccgatcctg atcttgtttt tgctatgggt attaaggaaa 795001 ggcggggcac tgttccgctc agtgcagaaa aggctggatc aagtgaacac catcatgcag 795061 gaaaatttaa ttgcaatcaa gctgatcaaa gcgctgcttc gcggcagcca cgaagtcaaa 795121 cgatttatca aagccaacac aaggctgatg gaaaaaacgg tttcggcctt tcagcttgtg 795181 gaattcacga tgcctgtact gatgctgctg atgaatctct gcatcctttt gattttgtgg 795241 gcggggtcct acagtattac gagcggaagc actcaggttg gcgatgttgt tgcgataatt 795301 aactacgcaa cacgaattac aggcgcgctt tcgatgtttc cgtttttgat tatgattttc 795361 acccgggcga aggcttcagg ggatagaatc ggtgaggtgc ttgaaacaga aggcgacgag 795421 cgggaggaag gcaccatatc tgatcgtttg tcaggacgga ttgagtttca gcatgtatcc 795481 tttcgctatc ctgaaatgga cagagaagcg ctcaggaatg tctcattttc cgcaaagcca 795541 agagaaacga tcgcgattct cggtgcgacg ggctcgggca agtccacgct ttttcagctc 795601 attccgcggc tttatcagcc ggattcaggc cgcatttaca tagatgaaaa gccggttcaa 795661 gatattccgg ctgaagggct gcgcaggcaa attggatatg taccgcagga agtcctcttg 795721 ttttccggca caatcaaaga aaacatcgct tggggcaaag aaaatgcttc actagatgaa 795781 ataatggatg cggcaaaact tgcgcaaatt catgaaacga ttttaaagct cccaaatgga 795841 tatgacactg ttttggggca aagaggcgtc aacctgtccg gcggccaaaa gcagcggatt 795901 tccattgcgc gggcgctgat tcgaaaaccg gctatccttc tattagatga cagcacaagc 795961 gcgcttgatc tgcaaacgga ggcgaagctg cttgaagcaa tcagcacata ccattgcaca 796021 actttgatca ttacacaaaa aataaccacg gcgatgaaag ctgatcagat tttgctgctt 796081 gaggacggcg aactgattga aaaaggcact cacagtgagc tgctttctga atctcagtta 796141 tacaagcgca tttacgagtc acaattcgga agggagggga gcgagtcatg ctaaaagaca 796201 tccgcaagcc tttccaatat cccaaactgc caattgacaa aaaagaaggc gcgaaaaagc 796261 gggcgaaagc aaaggataca aagggcacac tgagacgaat ctggtcttac ttggctgaaa 796321 gaaaaggact gctcatactt gtcatgctaa tggttgtcat cagcgccata ttcggactcc 796381 ttggtccctt tgtgatcgga aaggccatcg accattttat cgtcgggaaa acggtcagcg 796441 gcttgattcc tgttttgctt cttctgctcg ctatctatat cattcagtcc ctgtcgcttt 796501 ggtttcaaaa ctattggatg attacgatct cgcagggcac ggttttcaga atgagaagcg 796561 aattgttcac ccatctgcat gagctgccga ttccattttt tgataaacag cggcacggcg 796621 agctgatgag ccgggtgacg aatgacatcg aaaatgtcag ttctacctta aacacgtcag 796681 tcattcaaat tttgtcaagt gtgatcacct ttgtcgggac gattgcggtg atgctgtaca 796741 tgagcccgct ccttactttg attacgctga ccattattcc ggtgatggca gcgagcctga 796801 aatggatcac caaccgaacg ggaaagctgt ttaaagaaca gcagaaaaac cttggtgatc 796861 tgaatgggta tattgaggaa tctgtttcag gcgcaaaggt catcaaagca tattcacgtg 796921 agaagcagat tactgctgaa ttcctcgaaa aaaacgctgc actcaagacg tcgggctttt 796981 gggcgcagac gatttccggg tttattccga aggtcatgaa ctctttgaat aacttaagct 797041 ttacaatgat tgcggcaatc ggcggtttgt ttgcgctgaa aggctggatc tcgatcggct 797101 ccatcgttgt ctttgccgag tattcaagac aatttacacg ccctttaaac gatctggcca 797161 accagtttaa tacgatgctg tccgcaatcg ccggcgctga acgggtgttt gacgtgcttg 797221 atgaaaaaga agagcgcgag gatgaaaaga acgccgtgca tcagcccatc caaacaggca 797281 gcattgaatt ccgggatgtg tccttcggtt acgataaagg gcagcagaca ctgaagcatt 797341 tacagtttac cgtgcctgcg gggcagtcca tcgcgtttgt aggaccgacg ggggcgggga 797401 agacaaccgt cactaacctt ctcgcccgtt tttacgagcc taacgatgga aaaattttaa 797461 tcgatggtac agatattaaa acccttacta gagcaagcct aagaaaaaac atggggtttg 797521 ttcttcagga ttctttctta tttcagggaa cgatcagaga aaacattcgc tacggcaggc 797581 ttgatgcttc tgatcaggaa gtcgaagccg ctgcaaaaac agcgaatgcc catagtttta 797641 ttgaaaggct gccaaaaggg tatgacaccg tactgacgca aaacggttcg ggcatcagtc 797701 aagggcagaa gcagttgatt tctatagcga gggcggtgct tgccgatccg gttcttctca 797761 ttttggatga agcgacaagc aacattgata ccgttacaga agtcaacatt caagaagcgc 797821 tcgcccgttt aatggaagga agaacaagcg tcatcattgc ccacaggctg aacaccattc 797881 aaagagcgga ccagattgtg gtgctaaaaa acggtgaaat gattgaaaaa ggcagccatg 797941 acgagctgat tcggcaaaaa ggattttaca gtgacttata tgaaagccaa tttgagaaat 798001 agacctttgt cctgcacaga ggtctttttt tgttacagtt ttatagtact tttatttcat 798061 tttcgtaaaa tgtaacaaaa ttacttgacg taaacaagtt atgtatatat actagcttac 798121 attaagtaag tgataacatt tatcaaggag gataaaatga ataaatcatt tgaaattggc 798181 acattacttt taagagttat tacaggtatt atcttttttg ttcacggttt atcaaagttt 798241 cagggaatgg agggcaccat ccaatttttc ggcagcatag gccttccaag ctttatggcg 798301 tatgtcatcg cagcgattga actgattggc ggagtgcttg tcttcttcgg attggctaca 798361 cgtattgtcg gtgtactgtt cgctcttaca ctgatcggcg ccatcatcac tgttaagctg 798421 aaagcgccat tcatgggcaa tgcagaattt gattaccttc tgcttttgac atccattcac 798481 ctggcgctta ctggaagtcg attcctggcg ctggacccat ttgtgtttaa aggaaaaaag 798541 aacggaaacg tttcagcata agaaaagagg catgcagcat gaccagcatt catgaggata 798601 cacacattgg ctatgccaaa ctcacaattc gcagtctgga gcgttcgctt cagttctact 798661 gtaacgtcat cggttttcaa gtcttaaaaa agacggaccg ccaagcggaa ttaacggctg 798721 acgggaaacg cgtactgctt attcttgaag aaaatccgag cgctgtcgtc ttgcctgaac 798781 ggtctgtgac aggcctttat cactttgcga ttcttcttcc ggacaggaaa gaacttggga 798841 tcgcgctcgc ccgcctgatt gaacacggca ttgctatcgg acatggagac catgctgtca 798901 gcgaagcgct ctacctgtct gatcctgacg gaaacggcat tgaaatgtac gctgaccgcc 798961 cccgcagcac gtggcagcgt gatcgggaag gaaactacgt catgacgaca accgctgttg 799021 acattgaggg ccttctggaa gaggcaggag atgagcggaa aacatcgctt ccgaacgata 799081 caatcatcgg acacattcat ctgcatgtca gtgatttgaa agaagcaaag gcgttttata 799141 cagatgtact gggctttgac attgtcggaa actatgcggg catgtccgcc ctcttcgttt 799201 cagccggggg gtaccaccat catatcggct taaacatttg ggcgggaaga aatgcgccgc 799261 ctaaaccgac aaatgccagc ggactagatt attatactgt tgtcctgccc caccaagagg 799321 agctggattt ggtggcaaac cgagtcaaac atgccgggta ttcgattgaa gagacggaaa 799381 acagctttcg tgtgaaagac cctgtttccg gcgcctatat tacatttgtg atttaactgc 799441 aatccccttg ccgaaataac ggcaggggga ttttttattt ttgtccgcct tgttatgatg 799501 agagaaccaa cttgttagga ggcgtttaca tggaactcaa ccaccttgtg acgggcaaaa 799561 tagcattaaa tcaatatgtg catcgcttag agcaaaagga tgtttcattt tacgtccact 799621 actggggagc gatgacgaac cactataaca cactgcttca taagcattcc ttttatgaaa 799681 tttgttacgt ggtaagaggt gaaggatatt accttgaagg cgatcgtaca tatccgcttc 799741 gtgaacagac gatttttttg tcaaagccgg agcatttgca ccaaatcaaa agtgaaacag 799801 ggctgttcct tttttacgtc gctttcgagc tgagcgagga tcagtcaagc gccgaatgga 799861 tcaaagtgat ggaagaagtg aaacaaagcc cctttatcac aatgcaattg aaagatggcg 799921 aaccgccggg cctgctttgg aaaacgttaa tgctgcaagc agcgcaacct gtcaatgctt 799981 ttgacaaaga gatcctatct catttgtcgc atgcattgat cctgtcatta atccaaacct 800041 ttctcccgta cgcccaacgc ccgaaacaaa agcagcccat tcacacatct tctgctttgc 800101 tgacagaggt gaaactgcac ataaaagaca atctgtcaca gccgttaaag ctgacggatg 800161 tcgctagcca ctttcatatc tcagggaggc atttatcacg tttatttgca gcagaactgg 800221 gcgtcagcta ctcagaattt gtccaaaatg aaaaaataaa caaagctgcc gaactgctga 800281 aatcaacgaa tttgtcgatt aaagaaatag cggaagaaat cggtttctca gtacattatt 800341 tcactcgcgt cttttccgct aaaatcggca gctctccagg gcttttccgc tccctttata 800401 aagactcaaa aatgaccgca tttcaaatca ataaaccttt tcaaaaaatc gaacaggcca 800461 agccgcacga ataagatgtc ctgaaatgac aaaacaatgt cttcatatga taaagacgcg 800521 agaaatctcg ttgtcttata atctttttag aaagcggtta caacaagggg tattgctgaa 800581 ggagggatgc attggcttat gcttggtgtc gggtgctctg ccattcttga aagaagggga 800641 agaaagccgt gagtacaaaa aagaaagagg ctgtaatagg aaaagaaagc ttagctcata 800701 aagggctttt acgaacgatt acattggtat ctacattcgg cggcctgttg ttcggttatg 800761 atacgggtgt cattaatggg gcacttcctt ttatggcaac tgcaggtcag ctgaatctta 800821 cacctgttac agaaggactg gttgcgagtt ccctgcttct cggggcagcc ttcggggcga 800881 tgtttggagg acgtctgtcc gatcggcacg gccgccgaaa aacgatcctt tatttagcct 800941 tactcttcat cgcagccaca cttggctgta ccttttcacc aaacgcgtcc gtgatgattg 801001 cctttcgttt tctgcttgga ctggcggttg gctgcgcttc tgtaacggtt ccaacctttt 801061 tagcggaaat ttcgccggca gaacgcaggg gacgaatcgt gacacaaaat gaactgatga 801121 tcgtaattgg ccagcttctg gcatacacct ttaacgccat tattggcagc acaatggggg 801181 agagcgcaaa tgtatggcgg tatatgctgg tcatcgcgac acttccggct gttgtgttat 801241 ggttcggaat gctcatcgtg cctgaaagcc cgcgctggct ggcagctaaa ggcagaatgg 801301 gtgacgccct gcgggtgctt cggcaaatcc gtgaagacag tcaggcacag caggaaataa 801361 aagaaatcaa acatgcgatt gagggcacag caaaaaaggc cggctttcat gattttcaag 801421 agccgtggat aaggcgcatt ctattcattg ggattggaat cgccatcgta cagcaaatta 801481 ccggtgtcaa ttcgattatg tactatggga cagaaattct gagagaagcc ggttttcaaa 801541 cagaagctgc attaatcggc aatattgcaa acggtgttat ttcagttatt gcggtcattt 801601 ttgggatatg gcttctcggc aaagtccgtc gccggcccat gctgatcatc ggacagattg 801661 gcacgatgac agcccttctg ctgatcggga ttttatccat tgtccttgaa ggaacacccg 801721 ccctgccgta tgttgtgctg agtttgacca ttttgtttct tgcgtttcag cagactgcca 801781 tttctacggt gacgtggctg atgctctcgg aaatctttcc tatgcatgtg cgggggcttg 801841 gcatggggat cagcaccttc tgcttgtgga cagctaactt tctcattgga ttcacctttc 801901 ccattttgct caatcatatt gggatgtcgg cgacattttt tatctttgtc gctatgaata 801961 tcctagcgat tctatttgtg aaaaaatatg tgcctgagac aaaagggcgg tcacttgaac 802021 agcttgagca ttcctttcgc cagtatggcc gccgcgctga tcaggaaatc caaaatcaaa 802081 caactcactt atcgtaacct gagataccag gaggaatcta tcaatgaaac tatcttatgt 802141 aacagacagc ctagggcatt tgccttttga agacatgctc aattttgccg caaagcttgg 802201 gatcgataca cttgaaatga caaccggggg ctggtcgccg gcacctcact tgaatcttga 802261 tgaattgctg caaagcagcg aaaaaagaaa agaattttca caagcgctgg aaaagcggaa 802321 catgacactt tgcgcattaa actgctcggg gaacccttta gatccgggtg aattgggcaa 802381 atcgcacaga gacataactg acaaaacgat ggagctggct ggattattag gcgtcaaaaa 802441 agtgatcatg atgagcggtt tgccagccgg cggcccggac gacaaagtgc cgaactggat 802501 cacatacaca gtaagctggc ctcccgtttt aaaagatatc ctcaactatc aatgggaaga 802561 cgttgcgatc ccatattgga agaagcttgt caaaaaagcg gaggcctgcg gcgtggggaa 802621 aatagcgctt gagaacttca gctctcaatt agtctataat cctgagactc tctttcggct 802681 cagaaatgca gtcggcccga tggtcggttt gaatcttgac ccgagccatt tgttatggat 802741 gggcgcagac ccgatcatcg cagcaaggga gctcggctca gccattcacc atgtccatgg 802801 gaaagatgtc agaattgaaa gatatttatc ggcggtcaac ggacttttag aaacaaaaga 802861 agtgacagat cctgcaaacc gggcgtggaa ttacgtagct gtcggctgtg gacaggattt 802921 acagtggtgg aaggaatttt tttcagttgt aaaaatgatg ggatatgaag gtgaggtttc 802981 tttagaaatg gaggatctga cgatgtcacc tgaagcgggc atccgtactt ctgtagaagc 803041 tttaaaacaa accatcagcc aataggaggt tttcatgatg ctaaatggag aaagaatcat 803101 ctctaagccg cttcgctggg caatggtagg cggcgggcgg ctcagccagg ttggatataa 803161 acatcgtatt ggagcgctga gagacaatac tgcttttcaa ttaactgctg gcgcttttga 803221 tatcgatgcc gaaagaggaa aagatttcgg ggtgaacctt ggagtggatg cggaacgctg 803281 ttatcccaac tatcaaacca tgtttgccga ggaagcgaaa agacaggatg gcatagaggt 803341 agtatcgatt gccactccga acggcactca ttatgagatt tgtaaggcgg cgcttgaagc 803401 aggagtgcat gtcatctgtg aaaaaccgct gttcttcact tcagcagagg ggcaggaaat 803461 caaagcgctc gcagagaaaa aagggaaaat tgtcggcgtg acgtacggtt tttcaggcaa 803521 tcaaatgctt cttcaaatgc gtgcgatgat tgaacaagga atgatcggcg atattcgcgt 803581 ggttgacttg cagtacacac acggtttttg tgcaacagat gaaggtgaaa agataagcgc 803641 tgcacagaaa tggcgtgtcg accctgcgat cgccgggcca agctttgtgc tgggcgattt 803701 atctacccac acgtattata tgtcacagct tattatgcca aagatgaaaa ttaaggagct 803761 gctgtgtgac cgacagagct tcgtcggcag ccgcgcaccg ctagaggata atgcccatgt 803821 gctgatgcat tatgaaaatg gagcggtcgg aacgatgtgg acatcgtcaa tcaatgccgg 803881 atgtatggat ggccatagaa tccggattgt cggctcaaag gcaagcattg agtggtggga 803941 cagcaagcca aatgaactga cgtatgaagt gcagggagag ccgggccaga cactcgttcg 804001 cggcatgccg tatttagatg atgtttgcaa cgccgatgaa cgactgggcg ccttacacag 804061 cgaagggctg tccgaagcat gggccaatat ttatcttaaa tttgccattg cgatagacgc 804121 caaaaaccgt gaagatgaag aaatcttgaa caacttggtt tatcctgaca ttgatgcagg 804181 gatcgagggc attcgctgga ttgagaactg cgtgcgctcg gcaaaccaag ggtcagtttg 804241 ggttgaattt aaataaatga gggaatgcgc cgcatatgac ataaagttca tatgcggttt 804301 ttattttcca gaaactcctg tcaaaaatgc cctgaggcag gtatgataag aagggaattg 804361 ggtatcggga gtgatgagcg tgaaagctct tttttttacg agaatgttca ccttgatggt 804421 gagctgttta atgtatctgt ccattgtgaa agaggataac tggtttggat atgtatttat 804481 agcagcaggt gctgccatgt atgcagccaa tcatgttttg ctgacaaaag agacaaatgc 804541 catctggttc tgcctgattg atattgcaat cggcttttcg ttcggattta tctttcccgg 804601 cacaggtttg ttcattatta tgctttgtcc ggttgcggtc gccttttttc tgcgggggtt 804661 tcctaaaaga acagcatggt ctgtcttatg tctttcctct attttatttt tgaccgtcct 804721 catccgtaca tatgcgatgt tcggcaatga atttgtcatt gatcatttga ctagcatgac 804781 attcgttgtc ttctgcggtg tcgtgggcaa attaatccgc aagctgttgg atgcgcagga 804841 tacggcaaaa cagcagtttc aggaactgac ggagtcccat ctggcgctgt ctgctgcaca 804901 tcaggagctc catttatatg cgaagcaggt tgaagagctg actgccattt acgagcggaa 804961 cagaatggcg cgtgaaatcc atgatacagt ggggcataaa atgacggccc ttctcgtcca 805021 gctgcagctt ttgcgtgaat ggcaaaaaag agacagccaa aaagcggatg agacagtagg 805081 tgtctgtgaa acacttgccc gtgaagcgct tgatgatgtc cgcttatcag tacgcactct 805141 gcaaactgaa aacgatcctt cgctaatcga atcgctgaaa cagctgacag aggacttttg 805201 caaaaatgca ggagtcacaa cagaatttgc ggtcagcggt gatcctgcaa tcatcccgct 805261 gtctctccat ccgaccctga tcagaacggt gcaggaagca ctgaccaatg ccaaacggca 805321 cggcggcgcc gcagcctgtt cgatacagct tgcctgcaca acggacagca tcagccttgt 805381 cattaaggat gacggcaaag gcaatcctga ggcagcactt ggttttggtc tcttgaatat 805441 gaaaaagcgg gcagcggagc atggcggaat gatccgcttt gaaagcgaac gggatcaagg 805501 atttactgta aatgcagaat tttcacttgc caataaaaaa tggagcttcg ggcccgtgca 805561 gcaaaaggag agtttatcat gattaagatc atcattaccg acgatcagga tatcgtcaga 805621 gaagggctgg catccctgct ccagctccga gaagagctcg atgtgatcgc aacggcgcga 805681 aacggacagg aagccttcga aaaggcgaaa gagctggagc cggatatcgt gttaatggac 805741 atccgcatgc cggtttccaa cggggtggag ggaacaaaat taatcacaag ctcgctgcca 805801 agcgtaaagg ttttgatgct gacaaccttt aaggattcag cgctgattgc tgaagcgctt 805861 gaagagggag caagcgggta tctgctgaag gatatgtctg cagatacgat tgtaaaagca 805921 gtgatgactg ttcattctgg cggaatggtg cttccgccgg aattgactgc ccaaatgctg 805981 aatgaatgga agcgtgaaaa acagctgaaa ggaataaatg agatagaaaa acctaacgag 806041 ctgctcgacc tgaccgagcg cgaaatcgaa gttctggctg agctgggata cgggctgaat 806101 aacaaagaaa ttgccgaaaa gctttacatt acagaaggca cagtcaaaaa ccacgtttca 806161 aatattatca gcaagctggc tgtcagggac agaacccaag ccgccattta ctcggtcaga 806221 tatggtgtat ctgtcttttg acatatgacg ttttgcatat acgcttctct gaaaaggcct 806281 tttacaggcc tttttttcat gccctatgtt ctatctgccg ctacatgccg cacgcctttc 806341 tttcttctac aatggcaatg gatcaaaaaa aggagtgaga cgacgtgctg caagcagaaa 806401 acatcaaaaa ggcatacgga aaaaaaacaa tcgtgaaagg catttctttt tccctcaaaa 806461 agggggagtc gttcggtctg ctcgggccta acggtgcggg gaaatccaca accatctcga 806521 tgatttccgg ccttgtgccg catgacagcg ggaacatcac ggtgggcggc tatgttatcg 806581 gaaaagaaac ggccaaagcg aaacaaaaaa tcggcattgt tccgcaggaa attgcattat 806641 atccgacgct gacggctcat gagaatctta tgttttgggg gaaaatgtac ggacttacgc 806701 acggtgaggc caaaaaaaga gcggctgagg tccttgaata tgtcggtctg actgagcggg 806761 ctaaagataa gattgaaaca ttttccgggg ggatgaaacg aagaatcaac atcggtgcgg 806821 ctttaatgca taagcccgag ctgctgatta tggatgaacc gactgtcggt attgaccctc 806881 aatcgagaaa tcacatttta gaaacggtca aacagctcaa cgaaacgggc atgacggtga 806941 tctatacgag tcattacatg gaagaagttg agtttttatg cgaccggatc gggataattg 807001 atcaggggga aatgattgcg attggcacaa aaactgattt gtgcagccgc cttgggggcg 807061 ataccatcat tcagctcacg gtcagcggga tcaatgaagc gtttcttgtg gcgatccgat 807121 ctctggccca tgtgaatgat gtaacagtac atgaattaga gctcaaaatt gacatttctg 807181 cggctcatca tgagaaagtc gtcacaagcc tgcttgctga agccactgct catcatataa 807241 acctgctgtc tcttcaggtg caggaaccga atctggagcg cctgtttctg aatctgaccg 807301 gccgcacgtt gcgggattga ggagggacgg caatgaaaaa aagcatatgg atcgcatgga 807361 aagatgtgaa aatcagaatc acggacagaa aagggtttat gatgcttatc ctaatgccgc 807421 tcatcctaac ctgtatttta ggcgcagcgc tcggatcagt tgttgacgga ggcagccgga 807481 ttgatgatat caaagtcggc tacattcaat cagaccagtc agatacagca aacatgttta 807541 caaaagatgt tctcaaaaaa atgaagtcga taaaggtcac aaaagtcggc agcaaagaca 807601 agatgaaaaa actgattgat gaaaagaaaa tcgatgtagg catcgttatc ccgaaccatt 807661 gggaagccgg caaaacctca gctgttgtta atgccgctcc tgatcaaaca ttgaaaagtt 807721 ccatcattga aacagctgca agctcattta tagagcaata taaagcggta aaggaagccg 807781 cgtcaggctc aatggactac atcagtaaaa cggaagctgt aaagcaagga aaacttgacc 807841 ctgcacagtt tgcagaaaag ctggcaaaga cgctagaaaa agaaacaggt gacaagctta 807901 ctattgcgga aaaatctgtc ggcagcaaag ccgttaccag ttttcaatac tattcggcgg 807961 caatgctttg catgtttatg ctgtttcata tcacagtcgg ggcgaaatca tttttacagg 808021 aaaaggatac ggagacgctt gccagaatgc tgatgacgcc tgcgcaaaaa tccgtcattc 808081 tcttcggaaa atggcttggg acgtatctgt ttgccatcat acaatttttc atatttctga 808141 tcgtcacaat caacgtattt ggtgtggact ggggcggtaa tctgctgtta gtgagtgtac 808201 tcgggctttc ttacgccgca gctgtatctg gtatttcaat gctgcttgcg tcgtgcatca 808261 gcgatatgaa aactgcagat gcgataggcg gcttcggcat tcaattgctt gcggttctcg 808321 gcgggtccat gctgccgctg taccaatttc cggacgtctt gcagtctgta tccaaagcgg 808381 tgccaaatcg ctgggcgctt gacggctttc tttctttaat ggaaggggga ggctgggctg 808441 accttcaaaa gcctgtgctt ctttttgcgg cgatcggctt ttgttcactt gtaattggta 808501 tcagacggct tcatacaaga taaggaggta caaaaggtga aaaaaattct agccatttgc 808561 ggcattgagc tttctctcat ttttaagaag ccacagaact atttgatcat gtttgctgcc 808621 ccgcttttgc ttacctttgt atttgggagt atgctcagcg gcaatgatga taaggtgcgg 808681 cttgcaatcg ttgatcagga cgatacgatt ctctcacagc attatattcg gcagctgaag 808741 gcacacgatg atatgtatgt attcgaaaac atgtctgaaa gcaaagcgtc agaaaagctg 808801 aaacaaaaga aaattgccgg gatcatcgtc atttcccgct cgttccagac acagctggaa 808861 aaaggcaaac atcctgagct gattttccgt cacggccctg agctgtcgga agcgccgatg 808921 gtcaaacaat atgcagaaag cgcattggca acgctcaata ttcaggtgac cgcggcaaaa 808981 acggcatctc agacagcggg agagaactgg aaggcggcgt ataaaacggt tttcgccaaa 809041 aaacatgaag atatagttcc ggctgtaaca cgacagacgc tcagtgataa aaaagagggt 809101 gcggaagcaa gtgacacagc ctccagagca gcagggtttt ccatcctgtt tgtcatgctg 809161 accatgatgg gagcggctgg aaccatttta gaagcaagaa aaaacggcgt atggtccaga 809221 ttgcttacag cctctgtcag ccgagccgaa atcggtgctg ggtatgtgct gtccttcttt 809281 gtcattggct ggattcaatt tggaatattg cttctttcca cccattggct gtttggcatc 809341 aactggggga atccggctgc agttattgta ttagtgtcac tttttctatt gaccgttgtc 809401 ggcattggat tgatgattgc ggccaacgtc agaacgccag aacagcagct tgcgttcggc 809461 aacttgtttg tcatcgcaac atgtatggtg agcgggatgt attggccgat cgacattgaa 809521 ccgaaattta tgcaatccat cgctgaattt cttccgcaaa agtgggcgat gagcgggttg 809581 acagagatta tcgctaacgg tgcccgcgtc acagatattc tcggaatctg cggcattttg 809641 cttgcatttg ctgcgatcac tttcgcagcg gggctgaaag cgctccgagc ctaaaaaaca 809701 tctgccgttt aggcagatgt ttttttgcat gtgggtacat tcgtatgggt gcagcctgaa 809761 ctgcggttaa tccttatcta tcatagctaa aattgattcc agccaagaaa cgtaattttt 809821 ctcccgctcc agcgctttcg ttagcacaag atagtggccg aagtccggtg aagaaaatga 809881 catcggctct gctgaagcca taagcttttc atagcttccc tgtaagtcag aaagcttggc 809941 ctggcgtttt tgcagctggt ctttgaacaa atcagaagcc tcctggcgcg atagacaaga 810001 aatgaaataa gccttcagca taaattcatc cttcaccgtc tcgggtatcg gctggtggcg 810061 gatcagccag tcatgcagct cctgctttcc gctgtctgtc agggtgtaca tctttttctc 810121 cagctttgtg ccctgaatcg ttgtccggaa cgtgataaat ccttcatccg tcagcttttt 810181 gagctcaggg taaatctggc tgtgcttggc gctccaaaac tggccgagct cctctttaaa 810241 ataactcgta atatcgtatc cactcaattc gccttttcgc aaaagcccta atatggcgta 810301 ttttaatact ctcatgctat cctccgtgtc tggctgtttc gcaaaacaga tgagccggtg 810361 ctcaactgtg attctaactg cctattcccc ttattataga aaagggagga agggaacaca 810421 accgggctct ttggaaatga agataaaagg tttgtcagaa ggtatccgat ttatctccgt 810481 caatataaaa gagatttaaa tttaattttc agaaaaaata gtaacgatat tgatttttta 810541 tatataatag gaaattggtg gtatgaaaat tttttggggg aataaacgtg aaaaaagtac 810601 ttatggcatt cattatttgt ttatcgctga ttctatctgt tttagccgct ccgccgtctg 810661 gcgcaaaagc tgagtcagta cataatcctg tcgttcttgt tcatggaata agtggtgcat 810721 catacaactt tttcgctatt aaaaactact taatttctca aggctggcaa agcaacaaac 810781 tgtacgcaat tgatttttat gataaaacag gaaacaacct aaataacggc ccgcagcttg 810841 cttcatatgt tgaccgtgtt ttaaaagaga ctggggcaaa aaaagtagat attgtggctc 810901 atagtatggg aggcgccaat acgctgtact atattaaata tttaggcggg ggcaataaga 810961 ttcaaaatgt cgtaacgctt ggaggggcta atggtttagt gtcatcaacc gcgctgccgg 811021 gcacagaccc taatcaaaag atcctctata catctattta cagtctcaat gatcaaattg 811081 tcatcaatag cttgtctcgg ttacaaggag cgcgaaacat ccagctttat ggcatcggtc 811141 atattggctt gctttctaat agccaagtga acggctatat caaagaaggg ctgaatggcg 811201 gaggcctcaa tacaaattaa tatcttcaaa aaacaacctg ctgtctccgt tacagtgggt 811261 tttttcgtct gagaaagcca tagggtctta tgaccttagt ctatcatgca tacgtcaatt 811321 tatgacatca ggcacttttt caaatagagc ggacatgtta aggtacaacc atcgatttct 811381 atcaatttga aataaaagga gcgctgttat gcaaattaaa gaaattttta tgatccgctg 811441 catttcgtgc ttaagtgtcg tcttgctcca tatcatttca atggtcctga tgcttcaggc 811501 agaagctctt gcagatattt ctcacactgt tgattctttc cgcacactcc tgatgttcag 811561 cacgcccgct tttattttca tctctgaatt tttactggcc cgttcttatc ctgatggggt 811621 gcctgacggt tttttaaaga agcggggaaa agtgattttt gttccttttt tatttatcgc 811681 agccatcgat gcgctgctga tgaccagtgc gatgggggga gaggtaacct ttctcgcgtt 811741 tgtgcaaaaa tatctggcga acgtattctt aggaaacttt atcggatact tcattctcgt 811801 catctttcaa ttttacatgc tgcatatgat gtttcatgag tatttgaaaa aagcatcgcc 811861 gaaatgggtg ctgtctatct catttgtggt gacagccgct tatttaggct atttctccgc 811921 agccagcccg gctcctgctt ctgaagaggg aggggcattt ccgttcttct gggttccgtt 811981 cgcaggctgg cttttctact tttgtctagc ctactattgc ggaaaagaat acaagcgttt 812041 tttagcgctg ctgaaccaat accgctgggt ggtgtacggc gccgcaattg cttctggggc 812101 gctggttgtc actgtttctt atgtcggtga aatcggcatg atcagctcga agcggcctga 812161 tatcatgctg tattcaacaa gcatgatttt cctgtgtttt catttgtttt ccaaaatgaa 812221 gcatgtgccg aaaatcatga tgtttatcag caactattcc ttttcgattt atctgcttca 812281 tgcctatttt atgattatag gctacgtgtt gcttttgaat atgcccgaaa ttcctgccgt 812341 accggctgtt ctcctgttgt ttgccgtgtg cacagccggc ccgattatga cctcatgggc 812401 gctgaataag ttcaaatacg ggtatttatt tgtggggaaa atttatcagc caaaacagaa 812461 gaaggtaaca gtcgaagtgc gtgatcacgc agggtgaaaa acaagcggca ggagggctcc 812521 tgccgcgttt ctttacttct catccgcttg cagaactgtt tttaaatata gttttgcaga 812581 ctcagcaagt ccagatacat cagccttttc ttcatcgaaa tacagggcgt tttgaatgat 812641 gccgtcattc atattgagga aaaacttggc gatagtcgca agaggctgaa ccggctgaaa 812701 ctctccctga tcgatccctt tttgcaatag ccttgaaaac ctttccacaa aaagatcata 812761 ccttttctcc aaatactgcc gccgttcttc attgcgccaa gctgtcacta aatattcaaa 812821 ttgcaccggc gccagcgtat ctgctacatc tcgcaggccc tcagtcagtt catccaaata 812881 gctggaaatg gaggcccaaa cactttggtg ttcagctgat ttatcaagct ttcggagtcc 812941 ttcatccagc cctgtttcaa taatgcggcg aaacatctcc tcagtgcttg aaaaataaag 813001 atagacaccg ccccggctga aacctgactc ttctacaaca tccttcatcg tcgttaattc 813061 gaatcctttt cgtttaaaaa ccgttttggc agcctctaaa atctctgcct gccgtttatc 813121 cttgtgctcc tttgttactt ttggtgacaa gatatcgcct gctttctgca attttcttac 813181 ctataagtgt aatcaaccca atcatgatca gcaagcagcc acagacaaga aaagcaagtg 813241 atacaccgat ccattccgcc agcacgcccc cgcccgccat gccgaggata gaggcgaggg 813301 ttgtcgcact ctgaatagcg ccgaacaccc taccgctgta atcgacaggc actgttgttt 813361 gcacgagaat ctgaaatgga atatggacga ggccgaaagc cgcccccatg atgaaaaaag 813421 caaatataaa gagagtgatg ccggcaattc ccataccgct taggaatggc gcacctccag 813481 ttgctagtcc aagaagaagg gttccagctg agaaataaag caaataagaa gtgattcgcc 813541 gtctgccggt aatggccgct gtaaggagca tcccggctcc gcttacggcc atgcaccagc 813601 ctgccagctc gggcggagct cctgaaaagg agcggataag aataatcgct tgggaatcac 813661 caatctgcaa aacaaagaga acgacacaag ctgttagtaa gcctgttaat agaagcggca 813721 tccgtttcaa aaactgaagg ccttccttga tagaagtaag tgctgctgtt ttttcttgag 813781 gtgtattggc tttttgtaaa aaagcatctc tgggaaggaa aaacaaaatg acagcggaaa 813841 gaaagaaggc gccggcgttt atataaaaaa cagagtgtat cgagaaagca gcgatcagcg 813901 tgccgccaag ggcagggccg aagatttttg agctgttatc aatgatgctg ctgacggaaa 813961 cggcctgctg aatgtgtgct tccggagcca attccttaag ctttccgttt ttagcaggta 814021 aaaaaagtga agaaaaacag ctctgaacgg atagcaatac gtaaagctgc caaagctcac 814081 tgacataaac gcagctgata acagtgaggg cacggccgat ttcagataga aacatgatcg 814141 tttttctgtc aaaacggtcg gcaagcagac ccgatacagg tccgagtaca atgacaggca 814201 aagcaaacga catcattaaa agcgacatat ctaatggaga agcatgaagc tgaaaagcgg 814261 ctaatgttag cacggccaaa atgtgaagcc agtctccaag tgaagaaatg gtttgcgagg 814321 ctaacagtgt catcagtcct ttttgattgc gaaacaacgg tttttccatg attcatcctc 814381 ctgattatta aaatgacact agtgtcgttt ttaattgtat gggaaaaaga cacaatatac 814441 aatctttttc ttgtaaaata aaggagaaga ttgaatagaa gggagaacat tcatgacatc 814501 agtcaatcta agctacccaa taggagaata caagccgagg gaatccatat cgaaggagca 814561 aaaagataaa tggattcaag tacttgaaga agtgccggca aaattgaagc aagctgtaga 814621 ggtcatgacg gacagccagc ttgacacacc gtaccgggac ggtggatgga ccgttcggca 814681 agttgttcat catctggctg acagtcatat gaacagctat attcgtttta aattgagctt 814741 gacggaagag acaccggcta tccgtccgta tgatgaaaaa gcatggtcgg agctaaaaga 814801 ctcgaaaacg gcagatccga gcggctcact cgcgcttttg caggagcttc acggaagatg 814861 gacggctctg ctccgcaccc tgacggatca gcaatttaag cgcggatttt atcaccctga 814921 tacaaaggag atcattaccc tggagaacgc gctcggcctg tatgtctggc actcacatca 814981 ccatatcgct catattacgg agctttccag acggatgggg tggtcttaac gcttttgccg 815041 gcggaaagcc ggaatactga tagcagcaat caccagaagt gagaccacag cagccgctgc 815101 atataaatga tcatagccgc tggcgacact cgcatgaatg gcgtcgctta tcgcggtttt 815161 gacttcagga acgggaatgc gttcgatttg ttcttgtaaa gaagaaactt cagaactgtc 815221 gatctccgga atcatctgca tcgccttttc tgaatatccg ctgtccgata agcggctgtt 815281 gatctcatca cctatttggt caaacccggc tgtgataaaa cctgcataaa gagtaggcgc 815341 caaggtcagt ccaatttgcc ttactaatga aagcgtgcca agagctgtac ccttatttgt 815401 ttttgccgct tctgatacaa ggacgttcag cggagcgcct aacagaaagc caaaaccgat 815461 cccagctgcc acacttgcga tcacaaactc ccatttttcc gtgacccaga gcggaaataa 815521 agcaaacccc gcacatgaga tgattcccga aagaataacg gtttttacag gacctttttt 815581 gtcggtaagt gctccgccaa gccaagcgcc gattccggaa gccaacgcaa gcggtgtcat 815641 ccaatagcct gcttttgcgg cagggacacc caaatactgt tcgacatatg acgggataaa 815701 aatgactgcc gccaagagcc ccccggataa caaaccgatg ataagcgtgc gctgaaacat 815761 atggtttcgc agcagagaat acgccaaaat gggatcgcct cctcgcattt caactctctt 815821 ttcatacgag ataagcgctg caaaacagag tatgccaaaa ataatacatc cataaacctc 815881 cggattcccc aagctgtgta agagatttgc cccgtcaaga ttggtcatgc cgtacatcac 815941 agctaaaatc gacagggaca aaaggaagat tccggccgca tcgaggcgct tagcctcagg 816001 tgcttttgtt tccgcgataa aacatgcgcc gaaaacaacc aatagcacgg caatcggcaa 816061 attaatcaaa aatagccaat gccaagaccc ggtccaatca agcagaaagc ttccgatatt 816121 tggcccgagc acagcggcca tcccgttcat tgcgccaagc agcccaagcg ccttcccctg 816181 tttttccttt ggaagggtcg cgagaatgtg agagctgccg atgatgaaaa tcccgccgcc 816241 tccaagcgcc tgaatcagcc gcgatatcag aaagagcggg aagctttggc tcaaagcaac 816301 aagcaaagaa ccaagtccga acaggcaaac ctcaatgaga aagagttttt ttctgccgta 816361 gcggtcggaa agttttccga cgattggcac actgacgcta agaccgagcg tataaagggt 816421 aatgccccat gatccccagg aaggggaaac ggaaaacgac tcgtttatcg ttgttaaagc 816481 agccgaaata attccgttat ctaaagcagc cataaacacg ccaatcgtaa acaggctgat 816541 tgcccacttt tggcttttct gctctgttaa tgcttcagac attttcgtca actcctttta 816601 gttcacttga aatatattat tcattttaaa tgaactaaat gtcaaataaa aaaagcctgc 816661 tcccgcagtt tgcggatgac agacttactg atttattctt ttttcgcatt ctctaatgct 816721 cttgaaagga tagacagccc ttcgtaaaca gcctgctttt cttcagggga cagcagctct 816781 aatgaacgct tcaatttcag gtggcccttt tcatacaaac cccggaaaat ctttttcgca 816841 ttctctgtca actgaacaac tacagagcgg cggtcctctt cagaatgtga gcgtttgaca 816901 aatcctgatt tttcaagccg gtcaagcagc ccagttgtat tggacaggga agcccccatt 816961 ttttcagcaa tgtcgctcac tttcaatgtt ccatggttgt ttaatagcat cagcaccttc 817021 atttgcggca tgctcatatc cagtttcatc cactcggaca catcaccgag cccggcggac 817081 gttaagactt tcatatagag cacccatatt tcccgttcct ccgatgaaag aatgttttcg 817141 tttaagactg ttgtatcgtg taaattatat tccatttcat cacttcctca tcattcactc 817201 ctcttaccat attactcgat tttcactcct gaaagaaagt gagcagaaac cgcatgcggg 817261 actttgtccg aaaaataacg gtagtgtata atgagttgga gattattggg ggagaggatc 817321 gaactagaat atgattggag agaccattgc tgattaaaaa gaatgcttta tcaatattaa 817381 aaatcgtttt tcctattgct gttttgctat ttgttattta tcaatcgaaa aaagaactga 817441 caaatctgtc attcaaacgt acgctcatgg tcatcaacgg actggaacga acggatttat 817501 tcatgcttgt gttgatcggc ttgctggctg ttgcggctat gtcgctgtat gattacgtcc 817561 tgaagtactc actgcgccta tcgatcacaa acggaaaagt tttcagggtt tcctggatcg 817621 ccaattcatt taataatgtg ttgggattcg gcggtttagc cggagtcggg ttaagaatga 817681 tgttctataa ggagcatacg aaagaccata aggcactcgt gaaaggaatc gcctggctca 817741 catcatctat gctgctcgga ttatctgttt tcagcatttt cgttgctgcg agagtgctgc 817801 cagttgatga agtgattcat gagaagcctt ggctgtgggc ggtcgttatc ggttttgcac 817861 tgatattgcc gttatcttta gcggtgtcca aaataaaaga ccgcaaagct ggggacgaag 817921 agaatgcgga taaagtgaaa aatccgattt tcgcatatat tggagcttca gttgttgaat 817981 ggctcatggc cgggaccgtc atctattttg ctttgttcgc tatgggcatt catgcagata 818041 tcaggtatgt gttcggggtg ttcgtcattg cggcgatcgg aggaatgatc agcctcgtgc 818101 cgggcggctt cggctcgttt gaccttttat ttttgctggg gatggagcag cttggctatc 818161 atcaagaggc catcgttact tctattgtgt tgtacaggct cgcctactca tttatcccat 818221 ttatcttggg actgttcttt gccgccggcg acctgacgga aaatacaatg aagcggctcg 818281 aaacgaaccc gcgcatcgca ccggcaattg agacgacaaa cgttctgctt gttgttcagc 818341 gtgcggtatt agtgagaatt ttgcaaggct cgctttccct tattgtgttc gtagcaggtc 818401 tgattgtctt ggcctcagtt tccttgccga ttgacaggct gacggttata ccgcacattc 818461 cgcgcccggc gcttttgctg ttcaacggcc tgtccttaag ctcagcgctc attctgctca 818521 ttttgccgat cgagctttat aaacggacaa aacgttccta cacgatggcc attacagcgc 818581 ttgtcggcgg ctttgtgttc agctttttaa aagggcttaa catcagcgcg atattcgtac 818641 tgccgatgat tatcgtattg cttgtgctat tgaaaaaaca atttgtccgc gaacaggcat 818701 cctatacact gggacaattg atattcgctg tggcgctgtt tactgtggcg ctctttaact 818761 acaatctgat cgcgggcttt atttgggacc ggatgaagaa ggtgctgcgt cacgaatatt 818821 tcgtccacag cacctcgcat attacacatg caaccatcat ggcgatcatc attgtgccgc 818881 tgttcttctt gatatttaca gtggtctatc ataagagaac gaaaccgatc ggagagaaag 818941 ctgaccctga gcgtcttgct gcgtttctca atgaaaaagg cggcaacgcg ctgagccatc 819001 ttggttttct tggagataag cggttttatt tttctagcga tggaaatgca ctgcttctgt 819061 ttgggaaaat cgccagaagg ctggtcgtgc tcggcgatcc atctggccaa agagaatcat 819121 tcccgctcgt gctggaagaa tttctgaacg aagcgcatca gaagggattc agtgttttgt 819181 tctatcaaat tgaacgagag gacatggcgc tgtatcacga ttttggctac aacttcttta 819241 aattgggtga ggaagcatat gtagatttaa atacatttac cttgactggg aagaaaaaag 819301 ccggccttcg ggcaatcaat aaccgctttg agcgggagga gtatactttc catgtggatc 819361 atcccccatt ttctgatgcg tttttggagg agctgaagca aatctcagac gaatggctcg 819421 gctcgaaaaa agagaaggga ttctcgctcg gattttttga tccttcctat ttacagaaag 819481 cgccgatcgc ctatatgaaa aatgcagaag gagagatcgt tgcattcgca aatgtcatgc 819541 cgatgtacca ggaaggagag atatcggtcg atctgatgcg ctatcgcggc gacgctccaa 819601 atggcattat ggacgcattg tttatccgta tgtttttatg ggcaaaggaa gagggctgta 819661 cgtcatttaa tatggggatg gcacccttgg ccaatgtcgg cactgccttt acatccttct 819721 ggtccgaaag gtttgccgct gtcattttta ataatgtcag atacatgtac agtttcagcg 819781 gcctaagagc ctttaaagaa aaatataaac cggagtggcg agggaaatac ttagcgtatc 819841 ggaaaaacag atctctttct gtcaccatgt tcctcgttac acgtctgatt ggcaaaagca 819901 aaaaagactc cgtctaataa gacggagtct ttttttattt cgtttttaag aagtaggttt 819961 caatatcatc aagcaggtag tttgcggctt taattccgcc tgcggttgtc catacgacgt 820021 catcgacttc atgtgcatta cctgacttca cggccttcag gtttttccat agtgaactgc 820081 ttgtccactg attggcccat ttttcatttt cttttgcatt atcggcttta taagtgaaat 820141 aaaacagcac atcagcatcc atatcaggaa tagattcttt actgtcggtt gagaacgtaa 820201 attggtcctt ttgtttctta aacagttcca cttgtttttc agggcgtttg aagccaagct 820261 ggtctaaaat aatcccagga aatgaatcgg tataatagat tcttgattca ccggataaaa 820321 agcgtacgac tgaaacggtt ttgtttgtct ggtcgcccag cttgtttttt aaatcagaaa 820381 cacgtttatc aaaatcggca atgacttcct tgcctttgtc cgccttattc accgcgttgg 820441 cgtatagagt caggttatcc ttccagttcc cggccaaaga ttcagcaaaa acagtcggcg 820501 caatcgcatt taactgatca taaatttttt cctggcgcac tttgtttcca ataatcaaat 820561 caggctttaa ttctgcgatg gcttccacat tcggttccgt ttcaagaccg acgtttttaa 820621 cacctttcat gtcatctttc agatagtcat accacgggtc gcccttccat gactttacgg 820681 ctccgaccgg cttaatgcca agcgctaaga gcgcctctgt tccttcatta gttaaaacaa 820741 caatccgttt tggattggcg gggatgttgt ctgatgtccc cattgcatgt ttgaccgttc 820801 ttgttttgct gcttgacacc tcgctgttgc ttgaactttc tgaactatta caggcagaaa 820861 gtaccataac ggccattaaa aatacgaata gcatgctgat atgctttttc atctttttcc 820921 tcccaatatt gaaattcatt atcatttaga tcataataag cagtgttaag agtgtcaatc 820981 cctaattgag gattattctc aaaaacaaac attacatagt aaataactag gagaattaga 821041 tcatgatctg caaaaaggca tcttcaaaat ggattgtgtt agtatgtctg attttcattt 821101 tactgacggc tgtctgcgca agcgtcgtgt atggctatac aggtacgtca tggagacagg 821161 tctatcaggc gtttacttcc ttcaatggaa caaatgagca tgtcatcatc aaggatgtca 821221 ggcttccgcg cgctttggtt gcgacagtcg tcggcgcctc gcttgcagcc gcgggcgctc 821281 tcatgcaggc gctcacaaaa aatccgcttg cgtcaccggg gattttcggg attaacgccg 821341 gtgcaggttt ttttattgtt gccggatcgt tttttctgca tattcagtca cctcaggcat 821401 tagtatggag ctcgtttctg ggggcagcat ttaccgctgc gatcgtctat gcagcaggct 821461 cgcttgggag ggaagggctg acgccaatca aactgacgct ggcgggagct gccatggcag 821521 ccatgttttc ttctctgaca cagggcttgc tgtctgtcaa cgaactcgag cttgcccagg 821581 tgcttttttg gctgactggc tctgtgcagg gccggagtct ggatctgttg atgacgatgt 821641 ttccatatgc agcggcagcg ctggtaatct gcttctttct cggccaaaaa attaatctcc 821701 tcgttatggg agaagatgtg gcaaaaggac tcggccaaaa aacaggcctg ctgaaatttg 821761 tgatggcgct ttgtgttgtc atgcttgcag ggtccgctgt cgccattgcc gggccgattt 821821 cttttatcgg catcattatt ccgcattttg cccgctttgt cgttggtaat gattatcgct 821881 gggttctgcc attttccgct gttttgggtg ccattttgct tgtttgcgcg gatatcggtg 821941 cgcgatatat cattatgcct caggaagttc ctgtcggggt catgaccgcc atcatcggaa 822001 tgcctgtgtt tgtgtacatc gcaagaaggg gggcgaagct atgaaacttc gttttggcgt 822061 tactgcggct gaaaagaaag catggatcgt ctttttggtt ttactggggt taacagctgc 822121 tgtactcatc ataagcgctg gtctcggaca aaggtttatt cctccctggg atgtagcaaa 822181 aacattcttt ggtgcaggtt ccaagctgga tgaactgatg atcatgtcgt tccgcatgcc 822241 aagaattttg acggctttat gcgccggtgt ctgcttggca gcggcaggcg cgatattgca 822301 ggggctcgtc agaaaccctc tcgcatctcc ggatattatc ggaataacag gaggagcggc 822361 ggtagcggtc gtgcttttaa tgatgttctt ctcagaccgc agcagttcac ttacgatcag 822421 tctgtcatgg cttccagcag ccgcatttat cggcgcatcg gctgtcgggc tcatcgtcta 822481 tttactggca tacaaaaatg gcgcctccac atttcggctg gtgcttatcg gaatcggatt 822541 ttcaatgtcg gcgcaggcga tgactaccct gttgatgatc aaaggcccga tttaccgagc 822601 atcacaagcc aatgtgtata tcactgggtc agtttatggg tcaaactggc agcatgtaaa 822661 aatagctatt atcttatctg tcattctctt attcatttgt tttgtcgcgc taaaaaatat 822721 gaatatacag gtgctgggtg aagatattgc ggcgggtgca ggaagcgctg tgcagcgaaa 822781 tcgttttttc ttgctccttt tgagtacggc tcttactggt tgtgcagttt cagttgccgg 822841 cacaatcggt tttgtcgggc tgatggcgcc ccatattgca agacggcttg tcggctcatc 822901 ttatggcgcg ctgctcccag cgtcggcact tattggagct ctgctcgttt taacagctga 822961 tatcgtcggc agaaccttat ttgctccggt ggaagtgccg gccggcgtct ttacagcggc 823021 tatcggcgca ccttatttta tttatttgct ctataaaaca agaaattctt aatcgttaca 823081 cccattttct taaaaaagaa aatgggtttt tttgataatg actgaagatt cgtaattatt 823141 tttgctatac tgacagagac attgataaag aaagggcggc agatgaatga aagaagcaga 823201 ggtattaaaa tatgaagcat ttacaagcag tcccggcaaa ggaaaccccg caggcgtcgt 823261 tttgcaggga gacgattata cggaagacga gatgcagatc atagctgaac gtgccgggta 823321 ttcagaaacc tcctttatcc gaaaaagcga gtcggccgat cttgaactcc gttactttac 823381 ccctggacac gaaatgaatt tgtgcggtca tgcgacagtt gcttctcttt acgcattatg 823441 tgagaaagga atgctggaga gcggtaaaac gtacagcatc caaacgaaag cgggtatcct 823501 gcctgtgaag atttctgaaa aagatggccg cattcatatc acgcttgaac aggcctctcc 823561 gcaattcaaa ccatttacag gcgatcggaa aaaacttgcg gacgcactgg gtatcaccga 823621 tgaagatttt catgaagacc ttccgattgt gtttggcagc actgggatat ggacagccat 823681 cgttccgctt aaatcattgg aggcttccaa aaaaatggtg ccagataaca aacaatttcc 823741 ggaagtgtta gttgatctgc caaaagcttc agtccatccg tttacctttg aaaccgtcca 823801 tcccgacagc gacctgcacg ggcgccactt ttcatccccg tattcgggaa cgattgaaga 823861 ccccgtgacc ggcacagcat ccggcgtgat gggggcttat atgaaacatt atggcaatgc 823921 cgagcagcat aaatttatca ttgaacaagg gcaggaaatt ggaaaagacg gaaaagtgga 823981 gatcgaaatg aacgaagccg gcggccatgt gaaagtgaac atgacaggaa cagccgttta 824041 ctcagaaacc cgtattctta aaatctaata cggatgatgg tttacaaaaa gatgcacttt 824101 ccgttatcat tatgaaatga taatcatttt caattgcata ggaaggtgag acggtatgcc 824161 tcaaaccgaa caaatacatc agcattcagt actgagggac atcatacgca gcagaagatc 824221 gattcgaaag tttaaacaag agccagtacc ttcagcagtc attcttgaca tgcttgaaac 824281 ggcaaaatat gcgccaaatc acagagtgac agagccatgg agatttattt acgtttccag 824341 tgagacaggt aaagcgaacc tcattaatac atttgcagcg ttctctaaga aatccaagcc 824401 ggatatgaca gaggaaaagc ttcaaaattt caaaaacaca cttgggcgcg ttccgggatt 824461 tctcctcgtc gtgtttcagg aagatgaaaa cgaaagagcg cgggacgacg attttgcggc 824521 aacaagctcg ttgattcaaa atcttcagct tctcgcttgg gaaaaaggaa tcggcatggt 824581 ttggaaaagc ggaaaaatcc tttatgacaa agaagtccat caggcctttg gtttacagga 824641 taatgagcgt ttcgccgcca tcatacaaac aggttatcct gacgaggcgc cggaagtgaa 824701 aaaacgcaca ccgatccgcg accgattcac tgaaatgtaa aaaacccctt gtctcaaacg 824761 gagacaaggg gtttttcatt aacgagattt ctttttcgct ctgttgtcgg ctgctttcgc 824821 acgctcttgc gcttcgcggt catctgcatc agcaagctcg gttgaatatt cttcgtaaac 824881 gccgtcagtt tcccttttta aggcatcggg aacttgtgga agcttttgtt tgtttttatc 824941 acggtttttg tggatatgat ttctgcccat atcaaattcc ccctaaaaag tgatatcaaa 825001 caaatatagt atttggtttt aaggggctat gtattcctac ttccgcttag cagctttttc 825061 cgctttttta aattcgcctg aataaagaac ttcctgcatt tttttcaggt tggcgccttg 825121 ctggtgcttc tccctctttt tttccataaa aaggacctcc ttcaaccatg ttattcttaa 825181 ggttgacgct tcctgctgtt tttatacagt ctttcggtcc gctatcagct gtgagagtgc 825241 aaattcaaga tccgaatatg taaaacgaaa tccagaggtt atcgcttttt tcggaagagc 825301 gcgctgtcct ttcacaatca aaagactcat ttcacccaat gcttttgata aaaagaattc 825361 cgggacgggg agccagtgcg ggcggtgctt cacccgtgca atcgtttttc cgaattgctt 825421 catgtccaca ggattgggcg cggtgacatt cattgggcct gagatgccgg cgttttccac 825481 cgcatatcgg atcatctggg ccgcatcctc gacatgaatc catgacagcc actgccttcc 825541 cgttccgatc gttccgccgg ccagaaactt ataggggaga atcatgagcg ggagagcgcc 825601 tttttctcca agcatcacgc caaatctcgc ataaactgtc cggatgccca tcgcttcaat 825661 atgctgtcct tccttttccc acaggtgtgc agtatggctg agaaaatcct catctgacgt 825721 tgcagaatcc tctgtgaaag ttttctcaag gcttgtgccg taaatgccca cggcactggc 825781 ttggatcaat gtcttcggct tctccttctg tttctgaata agccgctgca cttcacgcgt 825841 cgcattgata cggctggaga gaatgtgctg cttcgttttt tctgtccagc ggccaaaaat 825901 cgattttccc gcaagattta tccagacatc aatatgagga agttcctgct ccggtgcggc 825961 tccttccgac agccattgga catatgtcat atttttttgt tcagtttccc ttgcgtttct 826021 tgataaaata taaacatggt gtccctggcg ggtaagaacg cctgtcagat gctggccgag 826081 aaaaccggtt ccgcccgtca ttgcgatatt catgaacatc tctcctcatc gttctaataa 826141 atatacttta cctcattgta ataaaagaaa acgcgtttca ggcctgagaa gggagattaa 826201 gatgccgttt attacaaaaa tatcaacgca aaaaaagaat acggaacgct tcaatatttt 826261 tctggatgat aaatacgcct tcagcgtgga cgcggatgtg ctcgtgaaat ttgagctcaa 826321 gaagggaaaa gaactcgatg atcttgacat cattgagatt caatacggcg atgaagtgaa 826381 gaaaggcttc aaccgtgcgc ttgacttttt atcctatcga atgcggtcga cgaaagaggt 826441 cgaggatcac ttaaagaaaa aagaaacctc gccccccgtc attgcggaag tcatccatag 826501 gcttaacgat tacaagtact taaacgacca ggaatttgcc gcagcctatg tcagcactca 826561 caaaaaaaca aacggaaaag gccctgatgt tttgttcaga gagctaagag cgaagggaat 826621 tgatgacgat acaattaagg aggcgctaag ttccttttcc tttgaagatc agacaagaga 826681 agcggtcaag catgttgaaa agcttctcaa aaaagataaa aagctttcga cgaaagaact 826741 caaacagcgc gcccagctgc agcttcagcg caagggcttc tcatttgatg ttatcagcgc 826801 ggcgatggat cagattgaat atgaaaatga tgaagacaca gagaaagaag cgctgcgcct 826861 tcacgcggaa aaagcgttta gaaaataccg ctatgacggc tcatatgaaa gcgccatgaa 826921 ggtcaaacaa tttttattcc gcaaaggatt ctcactcgat ttaatcgagc aattactgca 826981 ggaagaggag tactgaaatg gagaaacgat acagtcaaat gacaccgcat gaactcaata 827041 ccgaaatcgc attactttct gaaaaagcaa gaaaagccga acagcatgga atcataaacg 827101 aactggcagt gctcgaacgg aaaattacga tggcaaaagc atatttgctg aacccggaag 827161 attactcacc gggagaaaca tatcgtgtgg aaaacactga ggacgagttt accatcagtt 827221 atttaaatgg cgttttcgca tggggataca ggacctcttc ccctcagcaa gaggaagcgc 827281 tgccaatctc agtattgcaa gaaaaagaat aaagcgtaac aggaggctga tgatcagcct 827341 ctttttgttt gcagcacatt tacacgaatt cttaaagaaa aaatcattga attcacttga 827401 aaaatctttt aagatgaaac tcgttgtttt ttaaaatcaa aggaggcgat gacgttgagt 827461 atcaaaaacc catctgtaaa atttattata tttgttctta tgatttgtac attttcaatc 827521 ggctatacag aatacgcggt gatgggtatt ttgacgtcga ttgccaatga ctttcatata 827581 caggtttcat ccgcagggct tcttgtcacg gcttatgcgg caagcgtttg tttgacaggg 827641 ccgctcgtca ccatcatttc cgtcaagctt ccgagaaagc ctgtgcttct tgggctgatg 827701 gcgatattta tcctttccaa cctgatgagc gcactggcgc cgaattttgc ggtattggcc 827761 atttcaagaa ttttatctgc gtccattcac ggcgctttct tcgcgattgc catggtattc 827821 gcaagtgaaa tggttccgcc ggaaaagcgt gctgcagctg ctgcttcaat gaacggcgga 827881 ctgacagtgg ctctaatgct tggtgttcca ttcggctctt atctcggaga tgtcctgaat 827941 tggagagcgg tgttttccat cattacggca cttggtgtca tcggattttt aggccttatg 828001 gctgccgtgc cgaacagaaa accaaaagtg atcccaatgc ttatgaatga gtggggtgtt 828061 tttaaacaca aacaagtgct gttttccttc gcgattacca ttttaggcta ttccggtgtc 828121 tttatcgcct acacctttat cgaacccatt ttgaggcatt cagccggatt cagcacggtt 828181 ggcattacag gtgctctctt tgcgtatgga ttgggaggcg ttgccgggaa tttctttgct 828241 ggaaaggtac cgctgccttt gctgactcgg acgatgatcg gcgtaatgat cggtttaatc 828301 ggtgttctgg ctgtatttcc ttacatcgcc atttacccgg ctgcagccat tgtggcaacg 828361 ttcctattcg gggcatgcgc attcggcacg ccgcctcttc tgcaaacaaa ggtcatttcc 828421 tcatctgagg gcggcacaac cattgccgca gctgtcagcg tatcagcatt taaccttgcc 828481 aatgcccttg gtgcatggat cggcggaatg attttaaacg gaacaggctc ttattcctgg 828541 ctgtttgcag gaggtgcgct tatgaccgca tgcggacttg tgctttctac cttcgcacac 828601 ttatcagaaa agaagagcgt ctacgaatat caagtcaata aagggtaaaa aacagctgca 828661 gtgtatgcag ctgttcttct ttaccgtttg cctgaggctc tcattctttc ttgaggatgc 828721 tgattgatag atccgtcagc acgctttgaa gcatagtcgt cctttgctct cggttcaccc 828781 tgaaatttgt tttcgttttc gtaaggaaat cctttttctt tatttcggac catgtcatat 828841 ccccctaggt tcgagatcaa aaagttgcgt cttttcagat gaagacgtaa ggttagtata 828901 tggagaacac cacgtaataa agcgttattt ttttcctgaa gaaaggagac tgcacacatg 828961 aatatgtaca ttgagaaact gactaatctg cttctggaaa agaacgagat gatcagctat 829021 atacaggcaa aaacgtgggt ggaattgtta tggagcgatt tcgaagcaac ctacgcaaaa 829081 gccggacacg cctatcaagg tgaaaaaatg actgaaaaaa tcgtcacaca atggattgaa 829141 aactatggcg gccagctcca cctttttcaa agctcccgta acgacgtgaa tgattactta 829201 aatcaaagca gaggcctttt gcattaaaaa cctgccgtta acgaccggca ggttttttca 829261 ttttcttaaa attaccttaa caggaagaaa tcataaacaa aacatgtttc accagcctgt 829321 caatcaggga ataccactta tatcttgtca aaatgcgagg aggagcttta tatgaaaaag 829381 aaacaagtaa tgctcgcttt aacagctgcc gcaggactgg gtttgacagc acttcattcc 829441 gctcccgcag caaaagctgc gccccttcac gacatatctg tcagcatgcc atcatccgat 829501 acttacatca taaaagcagg aaagctgaat gtccggactg agccaaatca tgaaggtgat 829561 attctcggca ctgtatcatc agaacaaaag gtaaaagtcg ataggttcgt aaatgccgat 829621 tgggctcaaa ttcatttcaa aggaaagaaa gcatatattt caactcactt tttaatgaaa 829681 accgcaagcc aagcgaaaac aacgaaacag acagccttct atacaccgac gcccgaaaac 829741 ggaaaagcta agcagctctc atctggaaca gaggtgacaa tacttgggtg gggattcagt 829801 gaaaacggcg gatttgactt cacttgggcg ttcgtggatt atggcggagt taaaggctat 829861 attcacacaa aggatttaca aatgcgataa aaaggcaggc cgaggcttgt ctttttgcct 829921 atgcatgaaa catttcttct ttctgcacgt aacaatgaga aaggagatga tgatatgacg 829981 ggtttagtcg gcggagggct tatgatcatt gcgggcatac tgatcaaact gtttcctccc 830041 aaatcgatca acagtgtgta cggatacaga acgagacgct caatgtcaga tcaaagatta 830101 tggaatgaag cgaaccgtta cagtgcatca ttaatgatcc tgtcaggctt ggtgattgcg 830161 ggaatgggtt tgctgctggg atcaaacttg tttattcttc agcttatcct gctgattgcc 830221 gcctgtgtca taacatttat gctaacggag aaaaggctga aaatcatgac gcacagtcaa 830281 ggaggagata gaagtggacg gagttaaatg ccagtttgtc aatacgaacg gaatcacgct 830341 tcacgttgca gccgcaggac gggaagatgg cccgttaatt gtcctgctcc atggatttcc 830401 tgagttttgg tacggctgga aaaatcaaat caaaccgctt gttgatgcgg gttaccgggt 830461 cattgctcct gatcagcggg gctacaatct cagtgacaaa ccggaaggaa ttgattcgta 830521 tcggattgat acattaagag atgatatcat cgggcttatt acgcaattca ctgatgaaaa 830581 agcaattgtc atcggtcatg actggggagg agctgtcgca tggcatttgg cttccacacg 830641 cccggaatat cttgaaaaac tgatcgcgat caatatcccg cacccgcacg tcatgaaaac 830701 cgtaacgccg ctttatccgc cgcaatggct gaaaagctcg tatatcgcat acttccagct 830761 gcccgatata ccggaggcat cactaaggga aaatgattat gatacattag acaaagcgat 830821 tggattatcc gaccgtcccg cgctttttac atccgaggat gtcagcaggt acaaagaagc 830881 gtggaagcag ccgggcgcgc tgacagctat gctgaactgg tacagagccc tcagaaaagg 830941 aagcttggca gagaaaccct cttacgaaac agtaccttac cgaatgatct ggggaatgga 831001 agaccgcttt ttgagcagaa agcttgcgaa agagacggaa aggcattgcc cgaatggaca 831061 tctcatcttt gttgatgaag cttcccattg gattaaccac gaaaagccag ccatcgtcaa 831121 tcagctgatt ttggaatatc ttaagaacca ataagctaaa atttctctcc atccgtctgt 831181 cataatggca gactttttct gtgcgttttt tttcatagtc tgttttaaac atgacaaaat 831241 aacattaaaa atcatgaatg tcaccataaa attgtaacaa aaaacaggtt taaacgactt 831301 taaaaaaagg aatagcctta ctgaagattt gtgtaaaact cccctaaggc aatacttaaa 831361 aagaataata aaaagaaggt gccttaatga agcaaggatt aatctcgatt attatcccgt 831421 cttacaatga agggtataat gttaaactca ttcatgaatc tttaaaaaag gaatttaaaa 831481 acattcatta tgactatgaa atattcttca taaacgacgg aagtgttgat gacacgcttc 831541 agcagatcaa agacttggca gcgacgtgca gccgggtaaa atatatatct ttttctcgaa 831601 actttggaaa agaagccgca attttggcgg gctttgagca tgttcagggc gaggcggtta 831661 ttgtcatgga tgccgatctg cagcatccga catatttgct gaaggaattt atcaaaggct 831721 acgaagaagg gtatgaccaa gtcattgccc aaaggaacag aaaaggggac agctttgtcc 831781 gctcactctt atcatctatg tattacaagt tcattaataa agcggtggaa gtcgatttgc 831841 gtgacggtgt cggtgacttc agattgttaa gccgccaagc tgtgaatgca cttttgaagc 831901 tgagcgaagg aaaccgcttc tcaaaaggcc ttttttgctg gattggcttt gatcagaaaa 831961 ttgtatttta tgaaaatgtc gaacgaaaaa acggcacctc caaatggtcg ttcagcagtc 832021 tgtttaacta cggaatggac ggcgtcgttt catttaatca taagccgctg agattatgtt 832081 tttatacagg cattttcatc ctgctgcttt ccatcattta tatcattgcc acattcgtta 832141 aaattctgac taacggtatt tctgtgcctg ggtatttcac cattatctca gcagtgttat 832201 ttctcggcgg agtacagctg ttaagtcttg gaataatagg tgaatatatc ggccgaatct 832261 attatgaaac aaaaaaacgc ccgcattatt tgatcaaaga ggcgaatatc ccgaacaaag 832321 acctgcctga aacgaacgaa ttaaaaagca tgcggcgtct gacaaaaatg cactgaaaat 832381 accaagcgcc attggcagtg ctttttttgc gtgtctatta tcttaaaagc aagactggag 832441 aattcatatg aaaagaaaac atatcatgat ctatgcggcc agtttgctgg tgtccgttct 832501 ggcacacgct ttttttgtga aagaatgggc ggaaggcagg tatatgacag gtccgggtga 832561 cgggcttgcg caaatgatcg tatttaaaaa attattattt gaccaatata cacacgggaa 832621 ttttttctac aattattcat tcggacttgg cggcggcaca ttcagtcagc tcggctatta 832681 tttttctgcg tcttttcttt ttcttgctgt gtctgccgct gtttggctgc ttcaagccgt 832741 ccagctgatc ggagaaacgg atacgctttt ttgggcagag tcagctgttt ttatcagtat 832801 tttcaaattg agcttgatca tctttacgtc cgcttctgtt tttcattatc ttcttaagca 832861 cagggcggca tcgttcacgg gagccgtgtt atacggcgtc tcaattattt atttccgtca 832921 cgaagcgtat tgggaatttt tcaccgatac aatggtttgg cttccgctgc ttgtgcttgg 832981 cgcagaaaaa attattagag agcggcgtcc ggcgtggttt atcgttgcgt gttcgctgac 833041 gttaatcaac aatttttact ttgcatacat aaaccttata ttcatcggaa tctatgtgct 833101 gttcagatgg ctgatccgtt tggaaccaca tgaagagaaa agatggattc aaatcagatt 833161 atttctcgtt tcaggcttca tttcttttgg catcagtgcg gcggcgtttg tgccggtagt 833221 atacggtttt ttaaacaacc tgcgccctcc atacagccag aaaatagagt ggctcaattt 833281 cgatgataat atcttatttt cgagccggat catcattgtg ccggccgctt ttctgctgtt 833341 tttgtttatt atttcttttt acaaaaaccg tgtgtttcgt ctctttgccg ggttgagcct 833401 gctgtttatt ctgtttcatt tcagtccgta tgcggcaagc gtctttaacg gtttttccgc 833461 cccgcaaaac cggtttgaat atgttctggc ctttaccatt gcgggagcag ctgcggctgg 833521 tttgtcacag ctgtctgaat tgaaacggaa agaactgctc ccggccgcag ctgtcgtcct 833581 gcttctttac ttgtatcata tccaaaggta taagctcgat atatggaagc ctgcgaatga 833641 aagtattcta ttgctcttac tcatgacaat cgcagccttg tttgctgcag cttttgcgaa 833701 aaaacgggca aaaatggctg tgtacggtat aatcattctt tcttcgctgt ttgtcgccaa 833761 ctcctatcaa aaatacgcgc tctcagaagg cggcgatttg gacagtgtga caaaagaata 833821 tcttacaagt gaggaataca gagggcggga atcatctgag ctcatcagac gtttacagaa 833881 ggaagacgat gacccgctca tgagaatcga ctggatgaac ggggtccgca ataatacgcc 833941 aatcatttac ggatttaatg gcttcagcgc gtattccagc attttaaaca aagatctgct 834001 ggccttctat tggaatgatt taagcatcga tatgggcagg gaaagcgtca gccgttacgc 834061 gtcattggga gacagggcga atttatacag cctgctttac ggcaaatatt atatgaccga 834121 aaaaacaaac gaagccagcg tcccgtacgg cttcaaaaag catttagaaa cagagcatta 834181 tgcagtttat gagaatcagt acatgcttcc attcgttaaa acagcggatg ccatatacag 834241 cgaaagtgag ctggaccgat tgcccgctct tgcgaaagaa caggcgatgc tgaaaggaat 834301 tatattaaaa gatccatcag gaaaaacgga gcagacacca aaaccgtcca atttgatcac 834361 caagtcggac atcaccgcaa aacaagccca gtatcaaaac gggctgctaa ccgtaactgg 834421 agaaaacgga ggagagctga tcatcacccc gaaacagcca tcatccgctc cgggagacta 834481 ctatgtcagc ttttatttga aaagcaaagc aaaagacaaa ggatttacat taaaggtaaa 834541 tgattatgtc acaacaagga aatcgaacaa atcgatctat aaaaccggag taaataatat 834601 aacggtaaga gtgcctaaat caggccatat ctcaatcaat cttccgaaag gaacctatga 834661 gctgagaaac atagcgctct atgaagaaaa ttaccaaacg ctgaaaaacg ctgtaatgca 834721 aaataaaaca gagaaagcag acaaactgaa ttggaacaaa aatcgactga ccttttccta 834781 tcatctgtca aaagaccagt acatcatgct tccgatccca tatgaaaaag gctgggagct 834841 gaagatcaac ggaaaaacac agaagatcga aaaagcggat tatgctttta taggcttcaa 834901 ggcgcaaaag ggagacaatc acattgagct gacttactat ccgccatact tcaaaatatc 834961 ggcgatcata tctctcgtca gtctgctgct tgctgttttt tatataagac gtaaaaagcc 835021 cggctctata tagagccgag ctttaatttt ttctgaagtt tttcttcgct gaatatccat 835081 cccgtatagg atgaacgaat cgtgagatca tggccgatat gaacaattgc gacaaacgga 835141 taatggcctt tgctccgata acgcaggtcg ataaatctca cctcataatg atctttaaac 835201 gtatccactt cccaccggta taccggagaa aaggacagaa acgccgcgat gttatcatcc 835261 tgctttgccg catgcattac atcggtttca ggaacaggca cccgattaaa tgtatccaga 835321 atcacgacat gtccttccat gcttcttcct acatagaaag catgtgctgt cgtcactgcg 835381 attcgccatt gcctgaattt catcgttgga gaaataataa tgctttcgat ctcatcatga 835441 atcatctcat gaagcttccg tttaattctc agctgcatga tcaggcgcac caagtagtag 835501 cctaccaata tgatatataa gctgagaaac gtgatgccgg gactcccgcc tgcataccaa 835561 atcgcgatag ctgccagatg gctgataaaa ataaacggat caaacgtatt aatcagcccg 835621 agcgcaaccc attttttcga aaacggacga atggcttgtg ttccataggc gttgaatata 835681 tcaacaaaga catgcagaac gactgccagc agtgtccaca gccacaggtg cagaaaatcg 835741 gcctgaggat aaaataaata cagaatcgcc gggatgatga cagaccaaaa caaaacggcg 835801 ggaattgaat gggtaaatcc tctgtgattc cttatataaa cagcattgtt tttaagcttt 835861 aacacagtat caatatccgg agcctgagag cccgcaagcg ttgcgatcat aacagcgtga 835921 gccattgccg gatctgatcc gacaacagga tcaagcgtcg caataccgcc cagtgcgatg 835981 cccataacga catgtgtgcc cgtatccata ggtgacctcc ttgcagggtg atcctgcaca 836041 ttcactttgt aagaaattcc ccattttcat atacccaatt tttaaactga ttcaatcgtt 836101 ctcatatgtt tccgcttttt ctttattact atttaatgta acatattatc gtactgtgcc 836161 cttagtgtac aacaaaaaac agtctaaaga aaagcggggc gcgaaagact ggggagaaac 836221 acatatgaac gtacttgaag acaaattaaa acaaaaagac atacagcaat ttcgcgatga 836281 tttaatctca tggtttgaac gagagcagcg cgttttgccg tggagagagg accaagatcc 836341 atataaggtg tgggtatctg aagtgatgct gcagcaaacg agagtagaga cagtgattcc 836401 ttactttctc cggtttgtag aacaattccc gacagtggaa gcgctcgctg atgctgatga 836461 agaaaaggtg ctgaaagcat gggaagggct cggctattat tcgcgagtca gaaacctgca 836521 aagcgcggta aaagaagtga aacaggaata cggcggcatt gttcctccag acgagaaaga 836581 ttttggcggg ttaaaaggcg tcggccctta tacaaaggga gcggtgctca gcattgccta 836641 caataaaccc attcccgcgg ttgacggaaa tgtgatgcgt gtcatgtcca ggattctatc 836701 tatttgggat gatattgcca aaccaaaaac aagaacgatc tttgaagacg ccatacgagc 836761 ttttatttcc aaagaaaaac catctgaatt taatcagggc ttgatggagc ttggagcctt 836821 gatctgtacg ccaaaatcac cctcatgcct gctttgcccg gttcagcagc attgctcagc 836881 atttgaagaa ggcactgaac gggagcttcc ggtaaaaagc aaaaagaaaa agcccgggat 836941 caaaaccatg gccgcgatcg tactgactga tgaagacgga caagtgtata tccacaaacg 837001 gccgtctaaa ggtttgctcg ccaacctgtg ggaattcccg aatcttgaaa cacaaaaagg 837061 gatcaaaact gagcgtgaac agctcattgc tttcttagaa aacgaatatg gcatacaagc 837121 tgatatcagt gatctgcaag gtgtagtcga gcatgttttc acccacctgg tatggaatat 837181 ttcagtgttt ttcggtaaag taaaacaagt gtcggatacc agcaagctga aaaaagtaac 837241 gaaagaagag ctcgaacaat ttgcgttccc ggtgtcacat caaaaaatct ggaagatggc 837301 aggagaagca gccgccatct cggctgctcc gtaaaccatt cttaatcgta agagacgcgc 837361 gtgccgtggc tgtagtccgc ttcattgcgc ttcattccgc cgcgcgcttc aatttcttgc 837421 gttaattccc ggtattttga ttggccttct tcgttcaaat aaggcataat ttgctgaaag 837481 gcatgatgaa aataagcgag ttcactgttc ttccaatctt ttttggaaac catgttcaat 837541 tcgctcatat cacgtccgac atacataaca gaagaccccc tttaaagttc ttgccattat 837601 tgtttgtgga aataaaagaa ctatacgcta caaggagatg aggaaaaatg gaacaaaata 837661 aatgtgcact cgtaacagga agcagccgcg gtgtcggaaa agcggccgcg atcagacttg 837721 ctgagaacgg ctataacatc gtcattaact atgcacgcag caaaaaagca gcattagaaa 837781 cagcggaaga aatcgaaaag cttggcgtta aagtgcttgt cgtaaaagca aacgtaggac 837841 agcctgcaaa aatcaaagaa atgtttcagc aaattgatga aacgttcggc agacttgatg 837901 tttttgtcaa taatgccgct tcaggagtac taagacctgt catggaatta gaagaaacac 837961 actgggactg gacgatgaac attaatgcga aagcattgct tttctgcgct caggaagctg 838021 ccaagctaat ggagaagaac ggtggcgggc atattgtcag cattagttca ttaggctcta 838081 tccgctatct tgaaaactac accacggtcg gtgtatcaaa agcagcgtta gaggctttaa 838141 cccgttatct tgccgttgag ctttcaccaa aacaaattat cgtcaatgct gtttcaggcg 838201 gagcgatcga cacagatgcg ctgaagcact tcccgaatag agaagatctg cttgaggatg 838261 cgcgccaaaa tacgccggcg ggacgcatgg tcgaaattaa agacatggtt gatactgtgg 838321 agtttctagt gtcttccaag gctgacatga tccgcggaca gacaattatc gttgacggcg 838381 gacgctcact gctcgtttaa aaatttttaa aaaagaggaa tagctatacg atcacctgca 838441 cattctaatg accgtggagg tgataacaat ggctaactca aataacttca gcaaaacaaa 838501 cgctcaacaa gttagaaaac aaaaccaaca atcagctgct ggtcaaggtc aatttggcac 838561 tgaatttgct agcgaaacaa acgctcagca agtcagaaaa caaaaccagc aatcagctgg 838621 acaacaaggt caattcggca ctgaattcgc tagtgaaact gacgcacagc aggtaagaca 838681 gcaaaaccaa tctgctgaac aaaacaaaca acaaaacagc taatcactga aacagaaaaa 838741 agcacttcat cttcgggtgg aagtgctttt ttctgtttga aaaacgacaa aacttgtgga 838801 aggtctacag aatgagtcaa agggtttgct ttatggagat cgaaatgatt aaaggaggaa 838861 atgtttatac tttcatcagg ctgaaggagg aaccgatgac cgaatttgaa aagctggtaa 838921 gtgaacagat gaaaacgatg gataagcttc tcgatctcca atcagagctc gaccgctgca 838981 aacaaattga ggcggaactc cggcatttgg aaagggatgc aaggctgcgt gggattcagg 839041 ctgaaattgc ggtaaaacgg aaacaccttg ccgatataca ggatatgttt caaaagcaga 839101 cagagcaggt cattcgttca tatcgcagct cagaaaagcc gtcttccttt gtgtagtgca 839161 ggaatgtgcc attccccggc cggaatggct cttttatttt catttttcaa tttgtaacgt 839221 tataataggt aaaagacgtt gtcggtaagc aaatttggac atactaactg tagggcttta 839281 tagaaagtag gggagaaata tgggctatcc caaggaagga gaaaccattc aaattcacag 839341 ctataagcac aacgggctga ttcatagaat ttggaatgag acaacaatct taaaaagtac 839401 agaaatgtgt gtcatcggag ccaatgaccg gacgatggta accgaatcag acggccggac 839461 atggataacc agagagcccg caatctgtta ttttcacgca agacaatggt ttaatgtcat 839521 cgggatgctg agggaagacg gggttcatta ttattgcaac atcagttctc cgtttgccta 839581 tgatggcgaa gcaattaaat atattgatta tgacttagat gttaaggttt ttcctgacat 839641 gacctacaat attctcgatg aagacgaata tgatgatcat cggaaagcca tgaattatcc 839701 aaaagaaatc gacagtattt taagagacta cttaaatacg ctgctccatt ggattcacca 839761 gcgtcaggga ccgtttgcgc ccgagtttgt cgatatgtgg tatgaacggt atttgcgcta 839821 tacaaaataa tggttacgta aaaacctgtt gcggggtaca acaggttttt cacatgggct 839881 cacacacatc atgataaaga gagaggggga atcaaccgtg ggggttatga aacgctacat 839941 gcaattcgtc aaaccttata agaagcaaat tttcgttaca gtgttaatcg ggatcgtaaa 840001 attctccatt ccgcttgctc tcccattgct tctgaagtac gtagttgacg acattattca 840061 aggaggcggc acggccagtg acaaaaccac gtcattgttc acgattatgg cgatcatgtt 840121 cgccttattt ttaattttgc gcccgcctgt tgaatattac cggcaatatt ttgcccagtg 840181 gactgccagc aaggtgcttt atgatataag agctaagctg tttgaccata tacaaaaact 840241 gagccttcgt ttttacgcga atacaagaac aggggaagtc atttcccgag tgattaatga 840301 tgtagaacaa acaaaggatt tcgtcatcac agggctgatg aatatatggc tcgatatgct 840361 gacgattttg attgtaatct ctatcatgct cacactggac gttaaattaa cgctgatctc 840421 tatcgtttta ttcccattat acggaatatc agtgaagtat ttttacggcc gtttacgaaa 840481 gctgacaagg gagcgctcac aggctcttgc tcaagtgcag gggcatttgc atgaacgcat 840541 tcaaggcatg cctgtcatca gaagctttgc gatagaagat catgaacagg ctcaatttaa 840601 tgagaaaaac ggtcatttct tagataaagc catccgccac acgaattgga acgcgaaaac 840661 ctttgcggtc gttaatacca ttacagattt ggcgccgctc atcgtcatag cgtgcgccgg 840721 gtattttgtc attaatggac cgctgacagt cggaacaatg gtcgcgtttg tcggatatat 840781 tgacagaatg tacaaccctg ttagaaggct gatcaattcc tctacaactt tgacacagtc 840841 aatcgcatca atggacaggg tgtttgaatt tattgacgag ccctatgaac tcactgacaa 840901 accaaatgcg ataaaggccg atcagattcg cggaggagtg gagtttcaaa acgtttcgtt 840961 tcaatatgag aaggacaaag aaaatattct tcatgatgta tccttaaaag taaatagagg 841021 agaaactgta gctctcgtcg gcatgagcgg aggaggaaaa tcaacgctcg tcagcctgat 841081 cccaagattt tatgatgtaa caagcggcag actgctgatt gatgggacgg atattcgcga 841141 ttatgaagca agaagccttc gcaaccaggt tggtatggtg cttcaagata cctttttatt 841201 tagtgaaacg attcgggaaa atatcgcgat cggcaagcct gatgccacac ttgaagagat 841261 aatcgaagcc gccaaagctg caaatgccca tgaatttatc atgagttttc cagaaggata 841321 tgagacccgg gtgggggaac gaggcgttaa gctttcaggc ggacaaaagc agcggatctc 841381 aattgcgcgg gtattcctga aaaatccgcc gctcctcatt ttagatgaag ctacatcagc 841441 tctggatttg gaaagtgagc attacattca agaagcgatg gacaaactgg cgaaggatag 841501 aacaactttt gttgtcgccc accgtttatc gacaatcacc catgcggata agattgttgt 841561 catggaaaac gggacaatca ttgaaatcgg aacccatgat gaactcatgg actatgagag 841621 ccaatacaag cacttattta ccattcaaaa tttgaactaa aacatcaatc ttatatcctt 841681 ttaacgaagg atataagatt tttttgtata taaaaaaacc cggctgttta accgggttac 841741 tcttctgttt ctatttcgca gtctttcgga tgatacgttt gaaaacttgt gataagtgtt 841801 tctaaatgtt caagctgctc gcgatattcc acggcgcttg ccataatatt gagcatgttg 841861 taatcaataa gctcctcatc cgtattctgc tgatttttta aaaatgactt tgttaaaagc 841921 tgcttatacc ggatgccttc ttcaaccgcg tcatcatgcg gcttgatttt tccgacaaac 841981 ctcatcaaaa tccgctcgtg ccagtaaagc aggtaatcaa gttcttcagt caatgtttcc 842041 tgaaactctt ccggcatatg atagatctcg ttttccagac gatgcagctt cttcaatgta 842101 tcaagcgccc gatttgcagt aataatggcc tgtctgaaca ggacaagctt tcttgatttc 842161 acataagtcg ttttcttaaa gtaacttctt tcttctttat atagaagata tgtctgatca 842221 agcttgatca ttttttcttt cagtttttca atatcctctt tcaaaatcga atgctctgtc 842281 gactgccgca tggacaatct gatccacttc ataatttctt cggtgttttc gacggtatta 842341 tgaatcagct ttgtttcgta cttaggaggc aaaaacacaa ggttgacgat aaaggaagaa 842401 agcaccccta agatgactgt gcttgttctg atcagcgcga acattaaaaa gtcgtcaccg 842461 gcagattcta atatcgcaat gactgttaca agagcaattg aaattgtatg ttcaatttta 842521 agtttcagca tgattgtaat gacaataact gctgttaacc cgatcataat cgggctgggt 842581 ccgaaaataa ggccgaacac tgtggcaatc acagctccga tgatatttgc ttgaacctgg 842641 tcaataataa tgagaaaaga gcggtaaatc gacggctgga tcgcaaatat cgctgcaatt 842701 ccagcgaaaa tcggcgcggg aagcccgatc cacgaagcca aataaagggc aagtgtaatc 842761 gcaatcccgg ttttgaaaat gcgggcacca agtttcattg gtttgtgcgt gcattccttt 842821 ctatagtaaa ttgtgtgaca tagcaaatgg gctaatcctt aaaattcccg gttagtttat 842881 ttgctaaaca attaagtaat atacagggat cgatacaaat attcaagcta tttttctaga 842941 aaaagaccaa aatcttacac gctgtttgat tccataaaaa aacaggagct caaagctcct 843001 gttcaaggta tttgattcta gttttttaga tgtttaaatg catcctcgac cgctgtaagc 843061 gtgtctttaa tatcctgctc tgtatgtgct gtggtaataa accaagcttc atacttagaa 843121 ggtgctaaat taattccgcg ttccagcatc agcttgaaaa acgtagagaa tgtttctccg 843181 tcactccgtt cagcctgctc gtaattttcc actttctcat cagagaagta taccgtgagc 843241 gcacctttta accggttgac cgtaatggtg atgccgtgtg tttctgcgtg cttcaaaatg 843301 ccttcctcaa gcatagcgcc aaggtgatca agcttttcat acacgccttt ttctttgagc 843361 acttccagac aagcgatgcc tgataggatg gaagcggggt tccctgccat tgttcctgcc 843421 tgataagcag gccctagcgg agctacctgc tccatgattt cttgtttgcc gccataggcc 843481 ccaatcggaa gtccgccgcc gataattttc ccgagtgctg ttaaatctgg tttcacctgt 843541 aagagatcct gcgcgccgcc atacataaag cggaaagccg taatgacttc atcgtaaata 843601 acgagagccc ctgcattatg tgttaattca tttacttgtt ctaagaagcc ctctttcggc 843661 tccacgatac cgaagttgcc gacaatcggt tcaacgagaa ccgccgcgat ttcactgccc 843721 catttttcaa gagctgcttt atagctatcg atatcattaa atggtactgt gatcacttcg 843781 tttgcaatgc ttttcggtac accggctgag tctggtgtgc cgagagtaga cgggccggag 843841 cctgcggcga caagcacaag gtccgaatgc ccgtgatagc agcccgcaaa tttaatgatt 843901 tttgtccggc ctgtatatgc gcgagccacg cggatggtcg tcataacggc ttctgtaccc 843961 gaattgacga atcttacttt gtccatagcg ggaatggctt ctttgagcat ttttgcaaat 844021 gtaacctcgt gtttcgttgg tgttccatac aatacaccgt tctctgctgc ttttttaatc 844081 gcttctgtaa tatgcggatg ggcatgtcct gtaataatcg gaccgtacgc cgctaaataa 844141 tcgatgtatt tgttgccgtc cacatcccaa aaataagcgc cgcttgcttt ctccattgca 844201 acaggagaac cgccgccgac tgctttatat gatctagacg ggctgtttac accgccgaca 844261 atgtgctgta atgcctcatt gtgaagttca attgattttg tatgcaagaa taaaaacctc 844321 ctatatctcc atgcgtcctt tctattgtag catgcttccg aacaagaaca atggcttcgg 844381 gcttcagatt cagctgagat ggttgtaatc tggacaagaa ttggatacgc ttaataaaaa 844441 aacatccgga ggtaacgtaa tgactataga aatcggacaa aaagcgcctg atcttgagtt 844501 aaaaggtgat catggggaaa cagtaaaatt atcggattat aaaggaaagt acatcgtgct 844561 ttatttttat ccaaaggaca tgacaccggg atgtacaact gaagcatgcg attttcggga 844621 cagtcacgaa agcttcgccg aactggatgc cgtcattatc ggcgtcagcc cggacagcca 844681 ggaaaaacac ggaaaattta aagagaagca taaccttcca tttctgcttc ttgttgatga 844741 cgagcataag ctggcggaag catttgatgt gtggaagctg aagaaaaact tcggaaaaga 844801 gtatatggga atcgagcgtt ccactttttt aattgataaa gaaggccggc tcattaaaga 844861 atggagaaaa gtaaaagtaa aggaccatgt agccgaagcg cttcaaaccc tcaaagatat 844921 gtctgaaaag taaatctcta tgagcctatg cttactttta ccctgatatc aattgacaaa 844981 ttatcgtaga aagagttaca ctaattataa acattacaat gtaagaattt tttttagaag 845041 agaggtgcat gacggatggc tgcacatgaa ctaaaagaag ccttagaaac gttgaaggaa 845101 accggagttc gcattactcc tcaacgtcat gcgattctgg aatatctcgt taactctatg 845161 gctcatccaa cagcggacga tatatataaa gctctggaag ggaaatttcc taacatgagc 845221 gtagcgacgg tatataacaa tttgcgtgtg ttccgggaat caggtttggt aaaagagctc 845281 acatacggtg atgcttccag cagattcgat tttgtcacat ccgatcacta tcacgcgatt 845341 tgcgaaaact gcggtaaaat tgtggacttc cactacccgg gccttgatga agtggagcag 845401 ctcgctgccc acgtcacggg cttcaaggta agccaccacc gtttagaaat ttacggcgtc 845461 tgccaagagt gttcgaaaaa agaaaatcat taaaaataag ctgaccgcac gaaacggtca 845521 gcttatttta tttcgacatt ttctttttat tataagactc atcaaattct tttccttcta 845581 atcccttatc taaagtcagc ggctctcggc aatgcatgca catatcgact actcctaaaa 845641 cctttgtctc tttatcacag cctggacaaa tgacgcgaac cgctttagtc gaaagcattc 845701 cgatccaaaa gtaaactacc gtgctgagac cgatggataa aagcccaagt atcataaaca 845761 aactagaaag caaaactgac tctttgaaaa agatcccgat gtacataatg ataaacccaa 845821 cgaaaaccaa acttaacgca aatgttctga ttttattaat tttgctggag tatttcgcca 845881 tgtccatccc cctctgtttt aactatagca caaacccgat gggattttct tcatgttttc 845941 ggttgaactg gaatttacat atggagagtt actgtgaaat tgtttataat agttcaatgt 846001 gtttagaaaa aaggaatttc gttttaacca tagaattgaa tcaaatagag aataaaaaaa 846061 tttgaacaat tgcattggag gaatagtgat ggaaaatctt ctccgtccaa tttaccaaga 846121 aagagcaagt caccccaata cattggctgt cattatgatt gagagaagaa acaaaacatc 846181 ttccttaaca gataactttg atgcagcttt gctggtgatt gtaaaggatg ctgatgagcc 846241 agtttttata aagcattatg aatttgatca tcaaacagct tctttgcatg tggtaacaga 846301 ttctcagatt caagaatgga ttttgcttgg aacaaataga agaatcatag attggattgt 846361 aaatggcaga gtcttgtttg accgtaatga atacgtagtt gaactgattg acaggctgaa 846421 tacatttccg tttgccgaac gtaaactgaa gatcggactc gaatacggca aattaatcag 846481 aaggtatgtt gaagggaaag ctttttttga agccaatcaa tttttagatg cctacaatgc 846541 cgttgttcat gcgctgcatc atttagcacg tattgaagta atcgacagag gattccatcc 846601 cgaaaccacg gtgtggagcc aagtgcgcca gatggagccc caagtgtaca aattatattc 846661 cgagctgatt gaaagtcatg agagcctgga aaaaagactt gaattattat tcttagcaaa 846721 tgattttctc atccattcca aagccgagat cggttcggcg catcttttcg aagtaatgaa 846781 agaaaaagac atttggcaat tcggtgagct tcttcaacat catgacctaa agcactttac 846841 ccaagatctt ggcgttatgc ttgattactt gacggaaaag ggacttatca acgtctgcca 846901 gatagaaacg aaaggacagg ctgtctatca ccgaggatat tcttttaaaa aaggtgttga 846961 ctctgattct tgaccgtgtt atattattaa acgtcgctga tgcgcttctg agaaaacaag 847021 ctcacagcgg cgggaaaata aatcaaaaaa acatttgaca aaagaaagtc aaaatgttat 847081 attaataaag tcgcttcaac aagaagtgaa aatgatcttt gaaaactaaa caagacaaaa 847141 cgtacctgtt aattcagttt ttaaaaaatc gcacagcgat gtgcgtagtc agtcaaacta 847201 gggcctgcac gacgcaggtc acacaggtgt cgccgcagga tgcggtgaac ttaacctgtg 847261 atccatttat cggagagttt gatcctggct caggacgaac gctggcggcg tgcctaatac 847321 atgcaagtcg agcggacaga tgggagcttg ctccctgatg ttagcggcgg acgggtgagt 847381 aacacgtggg taacctgcct gtaagactgg gataactccg ggaaaccggg gctaataccg 847441 gatggttgtt tgaaccgcat ggttcaaaca taaaaggtgg cttcggctac cacttacaga 847501 tggacccgcg gcgcattagc tagttggtga ggtaacggct caccaaggca acgatgcgta 847561 gccgacctga gagggtgatc ggccacactg ggactgagac acggcccaga ctcctacggg 847621 aggcagcagt agggaatctt ccgcaatgga cgaaagtctg acggagcaac gccgcgtgag 847681 tgatgaaggt tttcggatcg taaagctctg ttgttaggga agaacaagta ccgttcgaat 847741 agggcggtac cttgacggta cctaaccaga aagccacggc taactacgtg ccagcagccg 847801 cggtaatacg taggtggcaa gcgttgtccg gaattattgg gcgtaaaggg ctcgcaggcg 847861 gtttcttaag tctgatgtga aagcccccgg ctcaaccggg gagggtcatt ggaaactggg 847921 gaacttgagt gcagaagagg agagtggaat tccacgtgta gcggtgaaat gcgtagagat 847981 gtggaggaac accagtggcg aaggcgactc tctggtctgt aactgacgct gaggagcgaa 848041 agcgtgggga gcgaacagga ttagataccc tggtagtcca cgccgtaaac gatgagtgct 848101 aagtgttagg gggtttccgc cccttagtgc tgcagctaac gcattaagca ctccgcctgg 848161 ggagtacggt cgcaagactg aaactcaaag gaattgacgg gggcccgcac aagcggtgga 848221 gcatgtggtt taattcgaag caacgcgaag aaccttacca ggtcttgaca tcctctgaca 848281 atcctagaga taggacgtcc ccttcggggg cagagtgaca ggtggtgcat ggttgtcgtc 848341 agctcgtgtc gtgagatgtt gggttaagtc ccgcaacgag cgcaaccctt gatcttagtt 848401 gccagcattc agttgggcac tctaaggtga ctgccggtga caaaccggag gaaggtgggg 848461 atgacgtcaa atcatcatgc cccttatgac ctgggctaca cacgtgctac aatggacaga 848521 acaaagggca gcgaaaccgc gaggttaagc caatcccaca aatctgttct cagttcggat 848581 cgcagtctgc aactcgactg cgtgaagctg gaatcgctag taatcgcgga tcagcatgcc 848641 gcggtgaata cgttcccggg ccttgtacac accgcccgtc acaccacgag agtttgtaac 848701 acccgaagtc ggtgaggtaa ccttttagga gccagccgcc gaaggtggga cagatgattg 848761 gggtgaagtc gtaacaaggt agccgtatcg gaaggtgcgg ctggatcacc tcctttctaa 848821 ggatattata cggaatataa gaccttgggt cttataaaca gaacgttccc tgtcttgttt 848881 agttttgaag gatcattcct tcgaaacgtg ttctttgaaa actagataac agtagacatc 848941 acattcaatt agtaatacaa gatatcacat agtgattctt tttaacggtt aagttagaaa 849001 gggcgcacgg tggatgcctt ggcactagga gccgatgaag gacgggacga acaccgatat 849061 gcttcgggga gctgtaagca agctttgatc cggagatttc cgaatgggga aacccaccac 849121 tcgtaatgga gtggtatcca tatctgaatt cataggatat gagaaggcag acccggggaa 849181 ctgaaacatc taagtacccg gaggaagaga aagcaaatgc gattccctga gtagcggcga 849241 gcgaaacggg attagcccaa accaagaggc ttgcctcttg gggttgtagg acactctgta 849301 cggagttaca aaagaacgag gtagatgaag aggtctggaa aggcccgcca taggaggtaa 849361 cagccctgta gtcaaaactt cgttctctcc tgagtggatc ctgagtacgg cggaacacgt 849421 gaaattccgt cggaatccgg gaggaccatc tcccaaggct aaatactccc tagtgaccga 849481 tagtgaacca gtaccgtgag ggaaaggtga aaagcacccc ggaaggggag tgaaagagat 849541 cctgaaaccg tgtgcctaca agtagtcaga gcccgttaac gggtgatggc gtgccttttg 849601 tagaatgaac cggcgagtta cgatcccgtg caaggttaag cagaagatgc ggagccgcag 849661 cgaaagcgag tctgaatagg gcgcatgagt acgtggtcgt agacccgaaa ccaggtgatc 849721 tacccatgtc cagggtgaag ttcaggtaac actgaatgga ggcccgaacc cacgcacgtt 849781 gaaaagtgcg gggatgaggt gtgggtaggg gtgaaatgcc aatcgaacct ggagatagct 849841 ggttctctcc gaaatagctt tagggctagc ctcaaggtaa gagtcttgga ggtagagcac 849901 tgattggact aggggcccct accgggttac cgaattcagt caaactccga atgccaatga 849961 cttatccttg ggagtcagac tgcgagtgat aagatccgta gtcgaaaggg aaacagccca 850021 gaccgccagc taaggtccca aagtatacgt taagtggaaa aggatgtgga gttgcttaga 850081 caaccaggat gttggcttag aagcagccac catttaaaga gtgcgtaata gctcactggt 850141 cgagtgactc tgcgccgaaa atgtaccggg gctaaacgta tcaccgaagc tgcggactgt 850201 tcttcgaaca gtggtaggag agcgttctaa gggctgtgaa gccagaccgg aaggactggt 850261 ggagcgctta gaagtgagaa tgccggtatg agtagcgaaa gaggggtgag aatcccctcc 850321 accgaatgcc taaggtttcc tgaggaaggc tcgtccgctc agggttagtc gggacctaag 850381 ccgaggccga aaggcgtagg cgatggacaa caggttgata ttcctgtacc acctcctcac 850441 catttgagca atggggggac gcaggaggat agggtaagcg cggtattgga tatccgcgtc 850501 caagcagtta ggctgggaaa taggcaaatc cgtttcccat aaggctgagc tgtgatggcg 850561 agcgaaatat agtagcgaag ttcctgattc cacactgcca agaaaagcct ctagcgaggt 850621 gagaggtgcc cgtaccgcaa accgacacag gtaggcgagg agagaatcct aaggtgatcg 850681 agagaactct cgttaaggaa ctcggcaaaa tgaccccgta acttcgggag aaggggtgct 850741 ctgttagggt gcaagcccga gagagccgca gtgaataggc ccaggcgact gtttagcaaa 850801 aacacaggtc tctgcgaagc cgtaaggcga agtatagggg ctgacgcctg cccggtgctg 850861 gaaggttaag aggagcgctt agcgtaagcg aaggtgcgaa ttgaagcccc agtaaacggc 850921 ggccgtaact ataacggtcc taaggtagcg aaattccttg tcgggtaagt tccgacccgc 850981 acgaaaggcg caacgatctg ggcactgtct caacgagaga ctcggtgaaa ttatagtacc 851041 tgtgaagatg caggttaccc gcgacaggac ggaaagaccc cgtggagctt tactgcagcc 851101 tgatattgaa tgttggtaca gcttgtacag gataggtagg agccttggaa accggagcgc 851161 cagcttcggt ggaggcatcg gtgggatact accctggctg tattgacctt ctaacccgcc 851221 gcccttatcg ggcggggaga cagtgtcagg tgggcagttt gactggggcg gtcgcctcct 851281 aaaaggtaac ggaggcgccc aaaggttccc tcagaatggt tggaaatcat tcgcagagtg 851341 taaaggcaca agggagcttg actgcgagac ctacaagtcg agcagggacg aaagtcgggc 851401 ttagtgatcc ggtggttccg catggaaggg ccatcgctca acggataaaa gctaccccgg 851461 ggataacagg cttatctccc ccaagagtcc acatcgacgg ggaggtttgg cacctcgatg 851521 tcggctcatc gcatcctggg gctgtagtcg gtcccaaggg ttgggctgtt cgcccattaa 851581 agcggtacgc gagctgggtt cagaacgtcg tgagacagtt cggtccctat ccgtcgcggg 851641 cgcaggaaat ttgagaggag ctgtccttag tacgagagga ccgggatgga cgcaccgctg 851701 gtgtaccagt tgttctgcca agggcatcgc tgggtagcta tgtgcggacg ggataagtgc 851761 tgaaagcatc taagcatgaa gcccccctca agatgagatt tcccattccg caaggaagta 851821 agatccctga aagatgatca ggttgatagg tctgaggtgg aagtgtggcg acacatggag 851881 ctgacagata ctaatcgatc gagggcttaa ccatattttt gaatgatgtc acacctgtta 851941 tctagttttg agagaataag tttttcaaaa aaacacttga ttttctcaag aatacatagt 852001 ataatgttaa atgtcactga aattgtctgg tgatgatggc gaagaggtca cacccgttcc 852061 catgccgaac acggaagtta agctcttcag cgccgatggt agtcgggggt ttccccctgt 852121 gagagtagga catcgccagg cagacttcat tccgcagtag ctcagtggta gagctatcgg 852181 ctgttaaccg atcggtcgta ggttcgaatc ctacctgcgg agccattatt ggagagctgt 852241 ccgagtggtc gaaggagcac gattggaaat cgtgtaggcg gtcaactccg tctcaagggt 852301 tcgaatccct tgctctccgc cactgatact tatacataat tacaattgaa agtctgggcc 852361 cgttggtcaa gcggttaaga caccgccctt tcacggcggt aacacgggtt cgaatcccgt 852421 acgggtcatt atatgatgga ggattagctc agctgggaga gcatctgcct tacaagcaga 852481 gggtcggcgg ttcgagcccg tcatcctcca ccattatatc atcgcggggt ggagcagttc 852541 ggtagctcgt cgggctcata acccgaaggt cgcaggttca aatcctgccc ccgcaaccaa 852601 attttaaaat ggtccggtag ttcagttggt tagaatgcct gcctgtcacg caggaggtcg 852661 cgggttcgag tcccgtccgg accgccattt gaatacttag gctcggtagc tcagttggta 852721 gagcaacgga ctgaaaatcc gtgtgtcggc ggttcgattc cgtcccgagc caccacctat 852781 gccggtgtag ctcaattggt agagcaactg acttgtaatc agtaggttgg gggttcaagt 852841 cctcttgccg gcactgtttt ttcaaaattt aatgtggagg ggtagcgaag tggctaaacg 852901 cggcggactg taaatccgct ccctcagggt tcggcagttc gaatctgccc ccctccacca 852961 tttatagggg catagtttaa cggtagaaca gaggtctcca aaacctccgg tgtgggttcg 853021 attcctactg cccctgccaa atttatgaca tcttgagatt atggcggttg tggcgaagtg 853081 gttaacgcac cagattgtgg ctctggcact cgtgggttcg attcccatca atcgccccat 853141 attatcattg ggctatagcc aagcggtaag gcaacggact ttgactccgt catgcgttgg 853201 ttcgaatcca gctagcccag tctcactttt tatatcaact gcatataatg tattaagtcc 853261 attaaaaatg cggaagtagt tcagtggtag aacaccacct tgccaaggtg ggggtcgcgg 853321 gttcgaatcc cgtcttccgc tccaattacg gcggcatagc caagtggtaa ggcagaggtc 853381 tgcaaaacct ttatccccgg ttcgaatccg ggtgtcgcct tcttattgcc ggggtggtgg 853441 aattggcaga cacacaggac ttaaaatcct gcggtaggtg actaccgtgc cggttcaagt 853501 ccggccctcg gcaccaattt tacttacatg gtaagttgaa ttggtgtttg tgttttatca 853561 ttataactaa tcatattaat gatctacata agtagatcat ttttttaatg ctttgattta 853621 tcataacaag ttaagttccg aggcctatta taaagcggct gtatagctag tctttcaaca 853681 cttttatttt atatttccat aaaaactttt ttgaaatacg ttgacacttt atgagatcca 853741 tgatatattt atattcgtcg gttagatacg acgtaaaact tgccggtgtg gcggaattgg 853801 cagacgcgca cgactcaaaa tcgtgttcct tctggagtgt cggttcgacc ccgaccaccg 853861 gtatactgaa aaacccgttt cttaacagaa acgggttttt attttttatt aaagaaaagg 853921 agcctcggct cctttttata cttactcagc gtattggtct aggatctctt ctagcacctc 853981 ttctagctct tctgtatctt caagctctga ttggctgaaa cggacgcgta caagctgttc 854041 tccgtcatta tacatctctt ccaaccaccc tcggagtcct cttgctctgc ggtcgacttc 854101 gaaaatgatt tccaaaccgt cttcgtctaa aaggaaaatg agctctaatt catcaagcat 854161 ctgacgataa tatccggaag tcggaacgaa ttcgaattct tgaacgaacg gaagacgacg 854221 ctggaagtag ggcgcttgtt cgcagtctgc ttcgttaaga cggaagccca ggttttcgat 854281 tgcttcaagc acattttcaa tccaagggtg cgcttcaacg aaaatgcggt catgatcgga 854341 tttatcgata ccgccttgaa tgtcaaggtc tgtcaccacg gcaacctcta ctttccctac 854401 agtgatcggc gtatctagag gcagagtgaa tgtgaacgga aattgatgct cttcaccagg 854461 ctgtatggta aatgaaccag tgacccggaa agaatgaatt gtagcgtatt tccggtgctc 854521 ttcatcgtct tttacaatga cataccgtgt gctaagctgt aaatcgatat aacggatgtc 854581 ctgagcgatt tttccgcctt tgacatgtac cgttccctgt acttcttctc ctggaaaata 854641 tgcgtctttt tctaaaattg tatctacttt tgcagctcca attccggcac ttgccgcaag 854701 cttcttaaaa aatgacatgt tagatcttcc cctttttctt ttttctcaac agatatacgt 854761 aagaaggagg aaaaaagatt cgtttgattc atactttttt cctattattc gtctcggcct 854821 agggacagac taagaataat attgaaaata aaggagtcga tggaagtgaa taaagaaagt 854881 ttggttgcag atgaattaca cagaatgttt ttggctggtg agctgcaaat cacagtagag 854941 gaggatataa acaatatttc cgaaaggctg agaaacggcg atctcagttt agaccgatta 855001 agcggtgaag acgtgtttat aaaagaaacg gtaaatgagg ctttaagaag agtggagcaa 855061 taaaaaagag acggcatctc atctttgaga tcccgtctct ttttgtggtc tttgctgtaa 855121 gataaaagcg aatcgatttg gaattgctca cccgagccac cccttttcta acagaagatc 855181 tgacagttca tcatggagat aaacagctgt atctaattga tcatgcaatg ctcttctgat 855241 gtggggattt tcggttgctg ttgttgcgac agtgtatttg ttaatgctgg tttttattgt 855301 tgttaacaaa tcaagaatat ctttgggaca aagactttgt tcaatgggaa accacctcct 855361 ttgttttttt agcagctcct gataagaaag tatttgactt tgtttcttgc ttctatacaa 855421 aatgctataa taagcaacaa attttgttgg ggggtgtgat gatgaagcag attattgcga 855481 tggggggcgg gggtttttcg atggagccgg ataatttgtc cctcgatcaa tatatcctca 855541 atcaatcaaa acgagagcag cctcgtattt gttttttgcc gacggcgagc ggagattccc 855601 aaaactatat tcagcggttt tatcatgcat ttcaaacatt ggattgcgtg ccgtctcatt 855661 tatctttgtt taagccacca tcatcagatt tagtttcttt tgttatggaa atggacgtga 855721 tttatgttgg cgggggaaat acgcggaatt tacttgtgtt atggaaagag tgggggctgg 855781 accatattct cagggaagca tggaagaacg gtgtggttgt agctggaata agtgccggtg 855841 cgatctgctg gtttgaagaa ggggtgacag attcagccgg accgctgaca agtttgaaaa 855901 gtttaggttt tttgcaaggg agcttttgtc cccattatga cggggaaaag gatcggagac 855961 cggcatacca ccagctgata tctaacaagt tcttatgcag tggctatgca gcggatgatg 856021 gggctgctct ccatttcata aatgatcagc tgtttcagac tgtgagttca aggtcgggtg 856081 caaaggcata tcgggtgatg atggctgaac atgaaatagc tgaaatcccg ttgccggtca 856141 aatatttagg gtgaaattgg ctgaatatta tctatattcc tctttttttc agattgattt 856201 tatgataaga tgagtgcgaa atcaatagtt actgggggtg cccgctttcg ggctgagaga 856261 gaaggcaagc ttcttaaccc tttggacctg atctggttcg taccagcgtg gggaagtaga 856321 ggaattgttt ttgttattgt cttgctgggc aataatatgt ttctttctga ctgtaaccgg 856381 gttcatttat atgaatccgg ttttttgtgc tggttatggg cttgattttg tcctttcaaa 856441 cgtagaaagg ggaaggaaaa gtaatgcaaa acaattcagt gcagcaagcc aacatttcca 856501 ttatgtcaag tttttcaggc agcaagaagg tatacgtgga gggttcttct tcggacatcc 856561 aagtgccgat gagggagatt gcattgagtc cgacgacggg atcgttcggc gaagaggaaa 856621 acgcgcctgt gcgtgtctat gatacaagcg gaccgtatac ggaccctgaa gtaaccatta 856681 atattcaaga aggattaaag ccgctccgcc aaaaatggat cacagagcgc ggtgacgtgg 856741 aagagtatga aggtcgggct ataaaaccag aagataacgg ttataaaaaa gcaaaaccaa 856801 acgtaagcta tccaggatta aagcggaaac cgctgagggc gaaggcaggt caaaatgtca 856861 cacaaatgca ctatgcaaaa aaggggatca ttacacctga gatggaattt atcgccattc 856921 gtgagcatgt gtctcctgaa ttcgtcagag acgaggtagc cagcggccgg gcgattattc 856981 cttcaaacat taatcaccct gaaagtgagc caatgattat cggccggaat tttcatgtga 857041 agattaatgc aaatatcggg aattcagcgg ttacgtcatc cattgaagaa gaagtggaaa 857101 aaatgacgtg ggccatccgc tggggagcgg atacgatgat ggatctctct accggaaaag 857161 atattcatac gacgcgtgaa tggattatcc gcaattgccc cgtgcctgtg ggaactgttc 857221 cgatttatca ggcgcttgaa aaagtaaacg gcgtagctga ggatttaacg tgggagattt 857281 atcgtgatac gctaatcgag caggcagagc agggagtgga ttattttacg attcacgcgg 857341 gtgttttgct taggtatgta ccgctgactg ccaaacggac aactggtatc gtgtcacgcg 857401 ggggagcgat tatggcgcag tggtgtctgg ctcatcatca agaaagcttt ttatacacac 857461 attttgaaga aatatgtgag attatgaaaa tgtatgatat tgctttctct cttggggatg 857521 gtttgcgtcc cggatcaatt gctgatgcca atgacgaagc gcagtttgct gaattagaga 857581 cgcttggaga gctgacgcaa attgcctgga agcatgatgt tcaggtgatg attgagggtc 857641 ctggacatgt tccgatgcat aaaatcaaag agaacgtcga taaacaaatg gacatttgta 857701 aagaagcgcc tttttacaca ttggggccgt tgacaacgga tattgctccg ggatatgacc 857761 atattacttc agcgatcgga gcggcgatga tcggttggta cgggacagca atgctttgtt 857821 atgtaacgcc gaaggagcat ttggggctgc caaaccgtga tgatgttcgt gaaggagtca 857881 ttacatataa gatcgctgcg cacgctgcgg accttgcaaa agggcatccc ggagcgcaaa 857941 tccgggatga tgcgttatcg aaagcccgtt ttgaattccg ctggcgggat cagtttaatt 858001 tatctcttga tccggagaga gcccttgaat accatgatga aaccctgcct gctgaaggag 858061 caaaaaccgc tcacttttgt tccatgtgcg gtccgaaatt ttgcagcatg agaatttcac 858121 aggatattcg ggattatgcg aagaaaaacg atctcagtga agcagaagcc ataaataaag 858181 gattaaaaga aaaagcaaaa gagtttgtcg atacgggaag caatttatat caataaaaaa 858241 aatgaagatg gagaatgctc catcttcatt tttttagaaa aacagagagc gtcgaagcgg 858301 aggaatactc tgttcaaagc ggaaaacatt ttctggatca tatgtcgttt tgacacggcg 858361 gagtcgttca acgttttcgc cgtaatatgt tcttggccag tttctgattt cgatatctgg 858421 ccaatttacg tagtctccca tcgtttcttt cgaaagggac gttctcagcc cctcaatcca 858481 gcggacattt tgtctttttt ctccagggga tgtccagttt gttaagtatt cctgggcgat 858541 gattgcgtca cgataataaa atgccgtttg gtcgggagcg acccgtccgg ctgccccgcc 858601 gagtgcttgc tgccagacac tggcgttttg attcggagcg tgctctaaaa agtgttttat 858661 tgttgagatc gcacgttctg ataatggctt ttcaatgaaa gagccggagc gtttcatttt 858721 ttgaggctga ttgcctcccg ggctgttaaa aaaggttacc gcttcaatga atggcgttgt 858781 ttttaccatt ccgcttgtcg gacttcctgc tttcaataaa ggctttaaca gtttttttaa 858841 ctctgttttt ggcccgacaa attggccgag ggcttctatg cggtttactt ctttaggcca 858901 aaactctatt gatgatgtaa gccggtcatc tgtatacggg gcccagttct gccacgtgtt 858961 atatacttcc tcaaaatcat cccatcccca tgtaatagaa aaaatcgaca cttgagagat 859021 gggcactgct ttaaatgtca tggaggtgac tatgccgaaa ttgcctcctc cgcctccctg 859081 agacgcccaa aataagtctg gatgatttga acagctgact gtaatcagat cagcgccctc 859141 tttttcgtct gctacgatca tctcaagctg cacgaggctg tcgcaagtaa gaccggcagc 859201 ccttgttaaa agtccaattc cccctccgag agttaaacct gtgagcccta cattagcaat 859261 ggtgcctgcg ggaagcgtca ggccgtattg ccagagtgtc cgatagactt ctcccaattc 859321 agcccccgct tcaatatagg ccagcttttt atcctgattc acagttattt ttttcatctc 859381 gcttaaatca ataacaagac cgttatttaa aagggaaaag ttctcatagc tgtgtctgcc 859441 gcctctaata cggaaaggca cacggttttc acgcgcccat ttcagcgcat tgagtgcatc 859501 ctgtttgttt tggcaaaaca caatgatgtc aggatacctt tctaagctta ggttaatatt 859561 ggttcttgct tcgttatagt ccggatcatc ccgtgtcacg atacgtccgg tcaattttgt 859621 cttttccaca ctcccacatc tctttctctc gtattctagt ttctctagct tatgcgtcag 859681 gggaaaagag tgtataagga aaaagcgggg atgcaatctg atacagtgtc aacaccctca 859741 aaaaatagtt gacaggtcgg tattgtatga attaacatgg tcagtacaaa tttttcaaat 859801 ttatcgcgct gatcggaaca ccgaaggctc ttatcgttta gataagggcc ttttttgtat 859861 gaaaaagggg ggattattga tgggagtcaa aaaagaaaag gggagaaaac gattcaggaa 859921 gcgaaaaacc tacgggaatc agattttgcc gcttgagctg ctgattgaaa aaaacaaacg 859981 agagattata aacagcgcgg aactcatgga agaaatttat atgaagattg atgagaagca 860041 tacgcaatgt gtaactaaat ataaaaaaac ccgctgacta caacgggttt ttgcatttct 860101 ccattaagaa tcttttttaa tcggcaatcc aaggccttct gccacgcgtt ttccgtattc 860161 aggatccgct ttgtagaagt gctcgatttg gcgcagcttg atttcttctt tttctaccgg 860221 cttcatggca ttaacgatat tttcaacaag gcgggtacgt tcatcttcac tcattaaacg 860281 atacagatcg ccggcttgag tgtagtgatc gtagtgatcg tagcttacgc tgtcagcgat 860341 accttgtacc ggatatgctg cttgcttatc ctcaggtgac tcttttggac cgccgaagct 860401 gttaggctcg taatacacag atccgccgcc gttatcatca aaacgcattt gcccatcacg 860461 ctgataattg tttactttgt tgcgtgcgcg gttgattggc agcgcttgat ggtttgcacc 860521 gacacggtag cggtgtgcat catgataagc aaaaagtcga ccttgaagca ttttatccgg 860581 tgaaacatca ataccaggca cgagggttcc aggtgaaaat gtcgcttgtt ctacctctgc 860641 aaagtagttt tccggatttc tgtctagaac catgcgtccg acctcgatta acgggtagtc 860701 tttttgagac caaacttttg tgacatcaaa cggatcgaaa cggtacgtat ttgcatcttc 860761 taaaggcatg atttgcacat atagtttcca tgcaggataa tcaccgtttt cgattgcgtt 860821 gaaaaggtct tctgtatggt aatcagggtt ttcaccggca atttttgctg ccgtattgac 860881 atcaaggttt ttcacgcctt gttctgtttt aaagtgatat ttaatccata cgccttcgcc 860941 ttcggcattt gtccatttga atgtatggct tccgaagccg tgcatgtggc gaagtgtcgc 861001 aggaattccg cggtcagaca tcaggattgt cacttggtgc agtgactctg gtgaaagtga 861061 ccagaaatcc catacagccg tagggttttt caggtgtgtt tttggatctc ttttttgtgt 861121 atggatgaaa tcagggaact taatcgcatc gcggataaag aatacaggcg tattgttgcc 861181 gacgatgtcg tagtttcctt cttcagtata aaatttaaca gcaaatccgc gcgggtcgcg 861241 aactgtgtca gcagagccaa gttcaccggc aactgttgag aaacggatga acaacggtgt 861301 gcgtttgccg acttcagaaa ggaaagcggc tttcgtgtat tttgttacgt cgtttgtcac 861361 ttcaaaatat ccgtgtgcgc ctgctccttt ggcgtgaaca acacgttcag gaacacgttc 861421 tcggttgaaa tgggccaatt tttcgagtaa atgtacatct tgaattaaag ttggtccgcg 861481 agaaccggca gtcattgagt tttgattatc tccaaccgga gcgccccagc tagttgtcag 861541 tttatttgaa ctcatgttat cacctcttgg aatttataag aacataatat catctctaag 861601 taaaaagtca atattatttt ataattatta taaaatagtt atctctatta atcgatatat 861661 agtatcgaaa ttgttgaaaa accttgttgt aacagctttt tatgacactt aataattttt 861721 ggagaaataa tttttccttc tctatttgcg aaacaagcag agtaagtgat aaacaaggat 861781 atcaaaaatc gtatttaaaa aagagttgac atatcggaat aatttgaatt aacatgttat 861841 tcaaacaaaa aaacaattgg gcagctgatc ggaccgccga aggctctcat ctctacaaga 861901 acagagatgg gggccttttt gttttttttg aaggcggggt tggcagaaag agagggataa 861961 aagtggctgt gaccatcagc atcaaagaaa aggcatttgt tcaagaaggc cgcaaaaaca 862021 cggtcttaga aaacatagaa ttatcaatcg caccaggcga atttctaacg cttatcggac 862081 cgagcgggtg cggaaaaagc accctgttaa agattattgc agggcttgat tctgaatatg 862141 acgggagtgt ggaaattaac ggccgcagcg taacagctcc gggtattcag caaggattta 862201 tttttcagga acaccgcctc tttccttggc tgactgttga gcagaatatt gcagccgact 862261 tgaatttgaa ggacccaaaa gtcaaacaaa aggtggatga actgatcgag attgtcagat 862321 tgaaaggatc ggaaaaagca tatccgcgcg agctgtcagg cggcatgtca caaagagtag 862381 ccatcgcccg ggccctgctg cgggagcctg aggtgctgct tttagatgaa ccgtttggtg 862441 cactcgacgc ttttacaaga aaacacctgc aggacgtgct gctggatata tggaggaaga 862501 aaaaaacaac gatgattctc gtgactcatg atatagatga atctgtttat ttaggaaatg 862561 agcttgcgat ccttaaggcc aaaccgggga aaatccataa gctgatgccc attcacctgg 862621 cgtatccgcg aaaccggacg actccggatt tccaagcgat cagacagaga gtgctgtcgg 862681 aattcgagaa aacagaagat ttggagtacg cagaaggatc agggatatag aaagggcgga 862741 agcggaaatg aaaaaaggac tcattgtatt ggttgccgtt atttttctgc tcgcaggctg 862801 tggagcaaat ggagccagcg gtgaccacaa acaattgaag gaaattcgta ttggtattca 862861 gcaaagctta agcccccttt tgattgcaaa agaaaaaggc tggttcgaag atgcatttga 862921 aaaagaaggc atcaaagtga aatgggtgga gtttcaaagc ggtccgcccc aatttgaagg 862981 ccttgcggca gacaaacttg atttttctca agtcggtaat tcgcctgtga tcgctggaca 863041 ggcggcaggc attgacttta aagaaatcgg tttgtctcag gacggcttga aagcaaacgg 863101 catccttgtc aatcaaaaca gcggcattca agacgttaag ggcttaaagg ggaagaaaat 863161 tgcagtcgcc aaaggcagca gcgggtttga ttttttgtat aaagcgcttg atcaagtggg 863221 gttgtcagct aacgatgtga caattattca gcttcagcct gatgaagcag cttccgcatt 863281 tgaaaacgga tctgttgatg cctggtccat ttgggagccg tacttgtcct tagaaacaat 863341 gaaacacgga gcaaaaatcc ttgtgaacgg agaaagcaca gatttatatt caccgggttt 863401 tactttagta agaacaaagt tttcagaaga gcatccagac gaagtggtcc gttttctgaa 863461 ggtgtttaat aaagccgttg tatggcaaaa ggaacatctg gatgaagcag cggacttata 863521 ttctgacatt aaagatctcg ataaaaaggt cgtcgaaaat gtgctgaaaa atactgagcc 863581 acttaatgag atcatcagtg acgacattgt gaaagcacag caggaaacag cagattttca 863641 atttcgaaca aaggcgatag ataagaagat tgatgtgaag gatgttgtcg ataacacttt 863701 tatcaaaaaa gcattagagg agcattcctc aggaggtgat caatgatgaa agcagaggct 863761 gcgggctcgc tgcccaaaac gaatgcggaa gcggtgcgaa aaaagcccgg aaggaagaga 863821 tacggctgga tgaaggggct tttactgccc gctgtcatca ttgccatctg gcaggtcatc 863881 ggcgggctgg gggttgtgtc cgctacagtg ctgcctacac ctgttacgat tgttctgacc 863941 tttaaggagc ttattttgtc cggcgaactg ttcggccatc tgcaaatcag catttatcgg 864001 gcggcacttg gttttttgct tggcgcgggg cttggattga tgatcgggat tttggccgga 864061 ttttccaaac ggacggagct gtatcttgat ccgtcgttgc aaatgcttag aaccgtacct 864121 catctggccg tcacgccgct gtttatttta tggttcggat ttgacgaagt atctaaaatt 864181 ttgctgattg cgctcggtgc cttctttcct gtctatatca atacgtttaa cggcatccgc 864241 ggggttgacg cgaagctgtt tgaagtcgcc cgggtgcttg aatttaaatg gcatcagcag 864301 atatccaaag tgatattgcc ggcagccctg cccaatatat tgctaggcat tcgcttatcg 864361 ctcggcattg catggctcgg gctcgttgtg gcagagctga tgggctcaag ctcgggagtc 864421 ggctatatga tcatggatgc gagacagttt tcacaaacga ataaagtctt tgcagggatt 864481 atcatttttg cagtggttgg aaagctgacg gattccttcg tcaggctgct tgaacgaaag 864541 ctgttaaagt ggagaaacag ctacgaagga taaaagatat aaaggggaga tgaatatgga 864601 aattctttgg tttataccga ctcatggaga cgcgagatat ttaggatctg aaagtgatgg 864661 acggactgcg gatcatcttt actttaaaca agtcgcgcag gcggcagaca ggctgggata 864721 tacaggagtt cttctgccaa cgggaagatc gtgcgaggac ccgtggctta cagcgtcggc 864781 actggcagga gaaacaaagg acttaaagtt tttagtcgcg gtaagacctg gtttaatgca 864841 gccttctctg gcagccagaa tgacatccac cctagaccgc atttcagacg gccggctgct 864901 gatcaacgtt gtggcagggg gcgatccgta tgagctggca ggcgatggcc tgtttatcag 864961 ccatgatgag cgctacgagg caacagacga atttttaacc gtttggcgga gacttttgca 865021 gggagaaacg gtttcctatg aaggaaagca tataaaagtg gaaaacagca atctgctttt 865081 cccgccgcag caagagccgc atccgcccat ctatttcggt ggttcgtcac aggctggaat 865141 tgaagctgcc gcaaagcata cagacgtgta cttgacatgg ggtgagccgc ctgaacaagt 865201 aaaagaaaag atagaaagag tcaaaaagca agcggcaaaa gaagggagat ccgttcgatt 865261 tggcattagg ctgcatgtca ttgcccgtga aactgaacaa gaggcatggg aagcggcaga 865321 gcgcttgatc agccacttgg atgatgacac cattgccaaa gcgcaggcag ctttgagccg 865381 ttacgactct tcaggccagc agcggatggc cgtccttcat caaggcgatc ggacgaagct 865441 tgaaatcagc ccgaatctgt gggcggggat cggcctggtc agaggagggg caggaacagc 865501 tcttgtcggt gatccgcaga cgattgccga ccggatagcg gagtaccagg cactcggcat 865561 agaatcgttt atattctccg gctatccgca tttagaagaa gcgtattatt ttgcagagct 865621 tgtatttccg cttttgccgt ttgaaaatga tcggacgaga aagcttcaga acaaaagggg 865681 agaagcggta ggaaacactt attttgtcaa agagaaaaat gcatgagttt aactaaaata 865741 cagccccccg aacatggtat gatattcaaa aaaagggggc tttttttctg aaaacattga 865801 gaagcgcggc agtcatttgc ctcatagcta tgctgtcagc atgcggacat tcaaaacaga 865861 tggaaatcaa agcggcggac atatcagatc ttgaaaaaaa cagaatggat gtcgcagctt 865921 cacaggcatt cactgccgaa gccgtcaata tcggtgaagg tatttcttca gctgacatgt 865981 acatcgaaca ttatcaaaag ggaaagcttg ttgagaggtt tggaccggtt cgtgcagatt 866041 attcagagga aaaaactgat accatacaat ttgtttattt tgagaatgaa gagggggaag 866101 gaaagaataa acataccacc attcattttg gcattgtgga taaacaggga actatagcgg 866161 ctgattcatc ggtgaaacgc gacgatagca caacacagga aatgactcag aatatttcat 866221 cgccggaacc gattactttc gagaagcctg ctttgatcgg cagcagtatt agagggactg 866281 acgagacaat gcacacctct gaacataaaa aagagctcat taagcatcaa gatgcgttac 866341 tgtattatgt ggaattgcat cattagaatg ggcggcttca ggccgtctgt tttacaaagc 866401 ggtatgcttg cttttttgaa tggtgaatga tacattttaa atcgtaacaa tttcgattta 866461 aagggaggct atgtgacttg gctaaaaaat caaaagtggc aaaagagtta aaacgccaac 866521 agcttgttga gcaatacgct ggtattagac gcgagttgaa ggaaaaagga gattacgagg 866581 cactcagcaa gctgccaaga gattcagcac cgggaaggct tcacaaccgc tgcatggtaa 866641 cggggcgccc gagagcatat atgaggaagt ttaaaatgtc cagaatcgct ttcagggagc 866701 tggcccataa aggccagatt cccggtgtga aaaaagcaag ctggtaagaa aaaactccgg 866761 ccgattacag cgcgccggag tttttttcgt ttttcttgaa agagatgacg taggaaaggt 866821 gctggatgat catgatgata aacacaataa taatagggaa aaacggaatg cgcgattgaa 866881 atagcggata aaaaatgaga agaaccgctg cggcaggcag cgagaagtag acagcgatat 866941 atgacgcgcg acatgctttt gccgtcatca tctgctctct ttcatcctgc tcttcaaact 867001 catcaggcag aagtagctgc tttctggcag ggcggctttt tttctgtaag tacaaataaa 867061 ccgcagacgc cgcaacaaac agaataaagg gagtgaggtt taaatcaaat accatcccgc 867121 cgctctttgt gccgaaaaaa gatgctatgc cttctgaggc ttcaaagtat gaaatcagcg 867181 cccagcatgc aaggccaaat aaaacaaggt gaaaagctgc ttttgttttc atgctcatct 867241 tagttttcct cctctaacca aaagacatcc tccattttca tggagaaggc tttgcagatt 867301 ttcagtgcta acagcagtga gggaacataa tcgccttttt caatcgctgc cacagtctgt 867361 cttgtgacgc cgaccgtttc tccgagtttt tcctgagaat agccgaagcg tgccctcagc 867421 tcttttactt tatttttcat catgacgtct gtccccttca caatctcgat tgattatatt 867481 gtatagtata cttaacatta tgtaaatgga acttaacaac tttacaaaaa gataactttt 867541 tttcgacaaa atttttatat tcccttgacg aaaaataaat aaacatgtaa tataaaaaaa 867601 gtcagagcgg tactgttgct gacaatcaca aatgcgggtg tagtttagtg gtaaaacctc 867661 agccttccaa gctgatgtcg tgagttcgat tctcatcacc cgctccatac atacgttatt 867721 aacgcagtgt ttcgtttctc agataaacga agtattgcgt ttttttatgt gaaaaagaac 867781 acggtattcg tgttctttta cgtaagccaa tgtactgtat gggtgccgcc gtgaatttgt 867841 tcaaacattt tcgttaatga tgataagagg ttaacagcgc tgcttttctc aatcgatggc 867901 gggaaaaaaa tgatttgcag catattctta gtctcgtttg aaacgggata gtggttgacg 867961 ctgtttttga aatcgccaaa aatgccgttt tcatcagaga aaagcagtat gttttctttt 868021 tctcccaatg agatccggac cggctcatga agctttccgg catcataaat cataataggc 868081 agagaatatt ttaatgcgaa aaaatcgatt gtgtcatggg ccgagtcttt actttccatg 868141 aattgttcct tggatatcgg gaccagcatg tcctccattg gggttgtttc tccctcaaat 868201 gaagggttaa gctgtttaaa gagtttctgc cattccttga cgaaggattc atcggatata 868261 ccgccgtccg catagtcgaa aaacaaggat tcttgaaaca ggcggagtct gcctttcagc 868321 atttgcggtg aggagccgac ttcgatattc tcataaatga cagcagctgc atgtaagccg 868381 gccgcacgtt cagtaataac agaatcaagt ttgatattca ctagcattca ctccagttac 868441 gtgatatcaa cctattataa acgctgtgtc gttttatcac aaagaaagga ggctgtgcaa 868501 aacatgaacg tttatcagct caaagaagaa ttaattgaat acgcgaaaag cattggcgta 868561 gacaagattg gttttacgac cgctgatact tttgacagtt taaaagaccg tttgattctt 868621 caagaatcac tcggctatct ctccggcttt gaagagccag atatcgaaaa aagggtgacg 868681 ccgaagcttc ttttgccgaa agcgaaatca atagtggcaa ttgctctcgc atatccttcc 868741 agaatgaagg atgcgccgag aagcacgaga actgagcgca ggggcatttt ttgcagagct 868801 tcctggggaa aagactatca tgatgtgctg agggaaaagc ttgatctgct ggaggatttt 868861 ctaaaaagca agcatgagga tatcagaacg aagtcaatgg ttgatacagg tgaattgtct 868921 gatcgcgccg ttgcggaacg tgccggaatc ggattcagtg cgaaaaactg tatgatcaca 868981 acacccgagt atggctctta tgtgtatttg gcggaaatga tcacaaatat cccttttgag 869041 cctgatgtgc cgattgaaga tatgtgcggg tcctgcacga aatgcttgga cgcctgccca 869101 acgggagcac tggttaatcc cgggcagctt aatgcgcagc gctgcatctc ttttctgacc 869161 cagacaaaag gatttttgcc tgatgaattc cggacaaaaa tcggaaaccg cctgtacggg 869221 tgcgatacgt gccaaacggt atgccctctc aataaaggga aggattttca tcttcatccg 869281 gaaatggagc ctgatcctga gattgccaaa ccgttattga agccgctttt ggccatcagc 869341 aatcgggaat ttaaggagaa attcgggcat gtctcaggtt cttggcgcgg aaaaaaaccg 869401 attcagcgaa acgccattct cgcgcttgcc cattttaagg atgcttccgc actgcctgaa 869461 ttgacggaac tgatgcacaa ggatccgcgt cctgtcatca gggggacagc cgcatgggca 869521 atcggaaaaa tcggagaccc cgcctacgcg gaagagcttg aaaaagcgct ggaaaaagag 869581 aaggatgaag aggcaaagct ggaaattgaa aaaggaattg agttgctaaa agcttcaggc 869641 atgactaaac aaggcctgtc ctgacatacg tatagagcag aaggaaaaaa cacttgagat 869701 catccaagtg ttttttctct ataaaaaagt atggcgggtg gggtgagctt gaagtacatt 869761 ttagaacaat tagcggagga gcggctgggc tttctggtta acgggcatgc tatgagacag 869821 gagtctcaag tcggagacct taaagtcatg gagcgtaaga aaaagcttct ggaaaaacgt 869881 aaagttgaca tcataaaagc gaaagcaaag gccgtgatta atcatgtgcg ggttgaggat 869941 gacggaacga cctgcctttc gtataccatc cattacgaat acgtgtgtaa ggaacaagat 870001 gacagcttgt atatagaaga gcacatagag gagcgaatgg ctttcctgta tgatcacatt 870061 ttgattagtg atcaggaaat tgcgaaaaag ccggctggat ttcatgaagg gaccagtatt 870121 attgactatt ctgaagctga agaggaaaga gaagcgtttg gcagggcttt tcaatacgat 870181 cgtctcggcg ctgtccaata tgccgagaaa ttttggaaca agcgcaatcc tgcttataaa 870241 aatttcagcg ataactgtac aaattttatt tctcagtgtc ttcatgcagg aggcgcgccg 870301 atgcgcggtc atccgaacag gggatcaggc tggtggatga aacaaagctc atggagctac 870361 agctggacgg tggctcactc tatgaaaatg tatttgtcga attcaaaggc cggactgcgt 870421 gcggtgcggg tgaaatcagc ggaagaactg atgccgggcg atgtgatttg ctatgacttc 870481 gaaggagacg gccggtttaa tcatacaacg attgtcgtgg caaaggacaa aggcaatatg 870541 ccgcttgtca acgcccagac ttatgacagc aggatgaggt attggtcata tgaggattct 870601 acggcataca cgccgtcaat acgatatgcc ttttttcata tcgttgatga tacgacaaaa 870661 gagtaattaa tgttataatg atgggcggat aagaaaaaca gaggtgaaca ttgtggcatt 870721 acatgtcgtt ttatatcaac cagaaattcc cgctaacaca gggaatattg cacgtacttg 870781 tgcagcaacc aatacaacgc tacacctgat tcgtccgctc ggcttttcaa cggatgataa 870841 aatgctgaag cgtgccggac tcgattattg ggagtttgtt aacgttgtgt atcatgattc 870901 gttagaagaa ttgtttgagg catataaaaa aggcaagttt ttctttatta caaaatttgg 870961 ccagcagcct catacatcat ttgattacac tgatcttgac gaggattatt tcttcgtgtt 871021 cggaagagaa acaagcggtt tgccaaagga tttaattcaa aataatatgg accgctgcct 871081 gcgtcttccg atgacagagc atgtcagatc gttaaatctg tccaatactg ccgcgattct 871141 tgtttatgaa gcgctgcgcc agcaaaatta ccgtgattta aaatagtgaa aaacccgctc 871201 atcgatgatg ggcgggtttt tttgcggatg ttgaaatgct ttgtttcgtt tttgggctta 871261 acaacgtaac agtgttatgt tacaatgtac ccatcaaagg agctggactt atggaagaac 871321 aattaatctc taaaaaagaa ttacttgaaa gaacatcgat ttcatacggt cagctgtatc 871381 gatggaagcg gaaaaactta atacctgagg aatggtttat tcgtaaatcc acatttacag 871441 ggcaagagac gttttttccg agagaggaga ttttaaaacg tatatcaatg attcaaaaga 871501 tgaaagaaaa tttgtctttg gatgaaatga gggaaatgct gtcgccgaaa atgaaggatg 871561 tcagcatgac cgctgatgaa ttgcttcata aaggtttggt ttcaaggcct gctcttgaag 871621 cctattcaga agacggagga agtccggttt tttcatccag cgatttgctt tcgctgtttg 871681 tgcttgaggg cctgctgcag tctggaaatg tcagccttgc agaagcaaaa atggctgcag 871741 aggtattaaa gaagcatgat actgaagaga ttgaaaaaca gacggagctg attgtgctcc 871801 gcaagctcgg tgtcacaact tgttttatag cggctgcggc ggacagcatt ttgtttgaat 871861 catccgtaaa ggttgtggaa cgggtagatt tattaaaagc ttcagaggaa ttaaaaacaa 871921 catttatgca ggagggccat caatggatgt agtggaaaag ctggtgataa atggatcagg 871981 aagttctaag ggaggaacat ttcaatcagt tgagattaat ggcagcggga cagtggccgg 872041 ggacgtggag tgtgacactt tttcttttaa tggaaacgga aaagcggacg gcagcgtcaa 872101 agcgaaagcg gtaactatca gcggttcagg aaagatacat ggagacgttg aagcagaatc 872161 tatccggatg aatggcactg gttttattca aggagaggta tctgcaaaac aattgaaaat 872221 cgctggatca tcaacatttg gcggcactgt caaggctgat ggaattgaca ttagcggaaa 872281 agctgtcatg gaagcagatt gtgaaacaga aacctttcaa tcagaaggga aatgcaaaat 872341 cagcgggctt ttaaatgcag accaggtgat cattaagctt tctgcagggg aaagctatgc 872401 gcgggagatc ggctgccgcc atcttcaagt gacctgcaga aaaggaatgc tgacattgct 872461 cagattgatg ccgcagcctg ttctaacagc agagctgatc gaaggtgacg tgattgaatt 872521 gacaaataca aaggcgaaaa ccgtgcgcgg taataaagtg atcatcggcc cggattgcca 872581 gattgaaacc gtcgaataca gcggggacta tacctgtgat ccaagcgcgt cggttgaaac 872641 atccacaaag ttgtaaggag gatcgtaatg gagacaacaa aactgggaaa tttaaaatta 872701 tatggcgctg ggcatgccgc aggaggcgcg tatcacaatg tcagcatcaa aggagaaggt 872761 atagttggag aagggctgtc tgctgtaggc tgccgcatat acggaacggg cctttttctc 872821 ggaaaagcag agactgagcg gctgcgtgtg ctcggagaaa gtgaatgtaa aggcgatctg 872881 acagccggca aaatcaatat atatgggaca atgaaagtca gcggctcact tcaatttgat 872941 cgattcaatc tgaaaggcca gactgaaatt ggcgggaata tgactggaga atcctgcgat 873001 gtgaaaggga agcttagcgt aataggtgat tgtgaaacag aaatgttcca tgtcacaggc 873061 tgtgttgatg tatcggggtt attaaattcg ggtgagatca agctgggatt gagccatgat 873121 ataagccatg tgcaggaaat cggcggaaca acaattacag tgaaaagacg cgcgagtttt 873181 tttagccgga agaaagggaa gctgatcgcc gatgtcatag aaggagatcg ggtttatttg 873241 gagaataccg aagcggcagt tgtcagggga aaagaagtga tcatcgggcc gggatgcagc 873301 atcggaacga ttgagtacga atacaaatgt gaatgcgatc cgcattcaca gattaaagaa 873361 aaaacaaaac tgtaaaacat tgttctgtta tacaaaaagg gtgctctttc aggagcaccc 873421 ttttttattc ttttccaggc ttgctttcgt atcctgcggt aaaaattgat actaaaaaag 873481 tgacaatgac acccatcatg atgattgttt tcaccgtctc tccccctctt caatttttcc 873541 gtgctgtccg agtctggatg attctgtatt tttctttatt atgaacggtc gcagtctgcc 873601 ttgtcaacga tgtatgagta tctttatttt taagaaacca aagcatgtat cacgagatgg 873661 cggcatagat tgtatcaaag taccttattt gcatagtgta tcaaacatga tagaggaggt 873721 ccttatggat atattaaaga aaattgaaaa gtacagagag gaagagcagc ggctgaaatg 873781 ggaaggaact ttcgccgatt atttggagat tattaaagaa aatccgatgg tcgcgcaatc 873841 tgctcattct cgagttttta atatgataaa agacagcggg atagaggaga ttgacggacg 873901 caagaagtac agtttttttg accgcgagct gttcgggctt gaagaatctc tggagcgtct 873961 tgtggaagag tattttcatc cggctgccaa acgtctagat gtcagaaagc ggattctatt 874021 gctgatgggg cctgtgagcg gcggtaaatc cacgctggtc acaatgctta aaaaaggtct 874081 cgaagcgtac acgctgacag ataatggcgc tgtatatgcg attaaaggct gcccgatgca 874141 cgaggaccct ctacatttaa tcccccatca tttacgcgat gacttttaca gagaatacgg 874201 cattagaata gaaggaagtc tttctccttt aaatgtcatg aggctggagg aagagtacgg 874261 aggaagaatt gaggatgtga aggtggagcg catcttcttt tcagaagata agcgtacggg 874321 aattggaaca ttcagtccct ctgatccgaa atctcaggat attgccgatt tgacggggag 874381 tattgatttc tcaacaatcg ccgagtacgg ttcagaatca gatccgcgcg cttatcgatt 874441 tgacggagag ctgaataaag cgaaccgcgg gatgatggag tttcaggaga tgctgaaatg 874501 tgatgagaaa tttctctggc atttgctttc cttgacacag gaagggaatt ttaaagctgg 874561 gcggtttgcg ttaatttctg ctgatgagct gatcgtggct cacacgaatg aaacggagta 874621 tcgctcattt atttctaata agaagaatga agccctgcac tcaagaatca tcgtgatgcc 874681 ggttccttat aatttaaaag tgtctgagga agagagaatt tatgaaaaaa tgattgcaga 874741 aagcgatgtg gcggatgttc atattgcccc gcatacgttg aaggtcgccg cgatgttctc 874801 aatccttacc cggttaaaag agccgaagcg gtcggatatt gatctggtca agaaaatgag 874861 actgtatgat ggggaaagtg tggaaggata taactctgtc gacgttgagg atatgaaaaa 874921 agaatataat gatgaaggca tgagcggaat tgatccgcgg tacgtgatca accggatttc 874981 ttcaacgatt atcagaaaaa atatggaatc gattaattct ctcgatgtcc ttcgctcctt 875041 aaaagaaggt cttgatcagc acccatcaat ttcaagcgag gacagggagc ggtatttgaa 875101 ttttatctct gccgcccgca aggaatatga cgatattgcg aaaaaggaag ttcaaaaagc 875161 gtttgtttat tcatatgaag aatcagcaaa aacacttatg gacaattacc tcgataacgt 875221 agaggcctat tgcaataaaa acaagcttcg tgatcctttg acaggagagg aaatgaaccc 875281 tgacgaaaag ctgatgagat ccatcgaaga gcagatcggc atttcggaaa acgccaaaaa 875341 agcgttccgc gaagaaattt taatccgcat ctcggcctat gcgagaaaag gcaagcggtt 875401 tgattacaat tcccatgaaa gactgcgtga agctattcag aaaaagctgt ttgctgatct 875461 gaaggatgtc gttaaaatta cgacctcaac aaaaacgccg gatgagcagc agctgaaaaa 875521 ggtaaatgaa gtcgtggccc gtttaattga tgagcacggc tacaactcga cgagcgccaa 875581 tgagctgctg aaatatgtcg gcagcctgct gaaccgataa gcaacgtgac ccgtccgaat 875641 agggcgggtt attttgtccc attttctaaa tagtttgtca attaaacgtg catatgtgca 875701 tatgatgaat ataaatcttt tcaaaagact tgtttcataa tctggcacaa gccggaatac 875761 gtatgtatca cgaccacaaa tggttaagga ggggaattca tgtcccaaaa tgacagcggc 875821 cattttttga tttctgagga aaactggtcc ctccatcgca aaggcttcga tgaccagcag 875881 cgccaccaga aaaaagtgca ggaagcgatc aaaaacaatc ttccggacct cgtaactgag 875941 gaaagcatta ttatgtctaa tggaaaagat gtagtgaaga tcccaatccg ttcacttgat 876001 gagtataaaa tccgttataa ctatgataaa aataaacatg tagggcaagg agacggcgag 876061 agccaggttg gagatgttgt ggcccgggat ggatcagaca aaaaacaagg gcctggaaaa 876121 gggcagggtg ccggtgatca ggcaggcgag gattattatg aagcggaagt ttcattaatg 876181 gatttagaag aagcgctttt taaagaatta gagcttccga atctccagca aaaagagcgg 876241 gacaatatca ttcatacaga tatcgagttt aatgatatcc gtaaaacagg gttaaccggt 876301 aatattgata agaaaagaac gatgatgtca gcctttaaac gaaacgcaat gtcaggaaaa 876361 ccgtcgttct acccaattta tccggaggac ctgaaatata agacgtggaa tgacatcaca 876421 aagcccgaat caaaagccgt cgttttagcc atgatggata caagcggcag tatgggggtt 876481 tgggaaaaat acatggccag aagcttcttt ttctggatga cccgtttttt gcggacaaaa 876541 tacgagactg tggaaattga atttattgcc catcatacag aagcaagagt ggtctcggag 876601 gaggattttt tctcaaaggg agaaagcggc ggaacaattt gttcttccgt atatcggaag 876661 tcgcttgagc ttattgatga aaagtacaat cccgcccgct ataacattta cccgtttcat 876721 ttttctgacg gtgacaacct gacatctgat aacgcgcgct gtgtgaagct ggtcaatgat 876781 attatgaaga aggccaatct gttttgctac ggcgaggtca atcagtacaa caggcattca 876841 acgttaatgt ctgcatataa aaatgtaaaa gatgagaaat ttaagtacta tattttaaaa 876901 cagaaatctg atgtttttca ggctctaaag aactttttca gaaatgaaga gtctggtgta 876961 agccatcaat tttcgtaatg aaaagcccat ttcagggctt ttttttattt aataaaagca 877021 agaaaacgct tgcgaaaaaa atacgggaga aaaagaaatt tttcctttga caaatcttct 877081 ttcatttatt aatattttat cttgtgaact attattgagg aatgaggtga aaaggagttg 877141 actgaatcag aacgtgcttt gctcactttt gaacagctct tcgatacgtc tcgggcgata 877201 tataaaaaac agaagaagat attggagatt gtgcttgagc cttttgatat tacagtcctt 877261 caatatttgc tgatgtttaa aattcatcaa agcggaagca ccccgctaag caagctggca 877321 atgtcgcttg atcttaagcc tgcttctgtg acgcggatga cagatattct gtataagcgc 877381 caattgatga atcgatatga cagtccggat gaccgccgta tcgtcatgat tcagttaacc 877441 gaagaggggg aagaactgat agaaaaagcc gctgtgcaat atgcaaaaat gggtgctggc 877501 ttgtaccaaa agcttgatac ctcccagctg cagtatttgc gcaaactagc cggaagttta 877561 acgaagcttg ctgaaggctg ttcagaaaaa agcggtaatt aaaaacttct cacatatttt 877621 caccagcttt ccgcaaaatg atagaggatg aaacgaaagg agaaaacaaa atgaacagag 877681 gacgtttaat tctgaccaac attatcggtt tgattgttgt tcttgcaatt atagctggag 877741 gtgcttacta ctattatcaa agcacaaact acgtaaaaac agatgaagca aaagtagcgg 877801 gcgatatggc tgctattact gctccagcag caggtaaagt atctgactgg gatctggacg 877861 aaggaaaaac agtgaaaaaa ggcgacacag ttgcaaaaat caaaggtgaa caaactgttg 877921 acgtaaaatc cattatggat ggcacaattg tgaaaaacga agtgaaaaac ggacaaaccg 877981 tacaagctgg tacaacaatt gcacaaacga ttgacatgga caacctatac atcacagcaa 878041 atattaaaga aacagatatt gcggatattg aagtaggaaa tagtgtagac gtagtagttg 878101 acggagaccc tgatactaca tttgacggta ctgtagaaga aattggttat gcgactaact 878161 caacttttga tatgcttcct tctacaaatt caagcggaaa ctacacaaaa gtaacacaaa 878221 aagttcctgt gaaaatttca atcaaaaacc catctgataa ggtgcttcct ggaatgaatg 878281 catctgttaa aatttctgag taaaacagat cagtcatcaa accatgaaag gaggttgtct 878341 tagatggcta caggcaaaga aaaaaatgca aaaaacccta tgtcattgct gattgtgcta 878401 atggcgggtt tatttttggc aattctaaac caaacactgc ttaatgttgc aatgccgcac 878461 ttaatgactg aatttggcgt aagtgcaacg acgattcagt ggctgacaac aggttacatg 878521 cttgttaacg gtgtattgat tccgttatct gctttcctga ttacacgatt tggccagcgg 878581 agtctctttc tcgtcgcgat gttttgtttt acgctcggta cgttagtctg cggtatcgca 878641 cctaacttct ctacaatgct gatcggccgt ttgattcagg ccgtgggcgg aggtatcttg 878701 cagccgctcg ttatgacaac cattctgtta attttcccgc ctgaaagcag ggggaaagga 878761 atggggattt tcgggctagc gatgatgttt gctccagcgg tcggcccgac tctttccggg 878821 tggattattg agcattatac atggcgcatt atgttttacg gacttgtgcc gatcggcgca 878881 attgttatca ttgtggcttt cttcatcttt aaaaatatgg tggagccgca aaaaatcaaa 878941 ctcgatactc ttggcgcaat cctctcgatt gtcggattcg cctccttatt atacggagtc 879001 agtgaagccg gatctgacgg ctggaccgac ccgattgtat tgtctacagt tattatcgga 879061 gccattgcaa ttgttgcttt tgttgttcag caattgcgtc atgatgatcc gatgcttgat 879121 ttcagagtgt ttaaatatga cattttctca ctctcgagtg tcattaatat cattattaca 879181 gtggcacttt acactggtat gttcctttta ccgatttatc tgcaaaacct ggtcggcttt 879241 acggcgcttc aatccggtct gcttctgctt ccgggtgcga tcgttatgct gattatgtca 879301 ccgatctcag gtattttgtt cgataaattc ggaccgagac cgcttgcgat tatcgggctt 879361 ctcgtgacag tggtaacaac gtatcaatac acgcaattga caattgatac accatataca 879421 cacatcatgc tgatctattc aattcgtgca tttggtatgt ctctcttaat gatgccagtc 879481 atgacagccg ggatgaacca gcttcctgcc cgtctgaaca gccacggaac ggcgatgagt 879541 aacacgcttc gccaaatcag cggatcaatc ggaacaagtt taattacgac gatttataca 879601 aaccggacga cattccatta ttcacaaatt gcagataaaa caagcacggc ggacccgaac 879661 ttcctccatg cgttccaaaa tgcagtttcg aatttaatgg tgaatatgaa tgtgtcttat 879721 gatacggcga aaacatatgt gtactcacat atttataaac acgcatcact cgattccaat 879781 gtcatgggga taaatgatgc ctttatgtgg gcaaccttat tctgtgtagc aggtttgatt 879841 ttaagtatct tcctgcgtga cgtcagaaaa gataaattgc gtaagaagaa aaaagaggag 879901 ctttcattac ttcctgctcc aaaagaagct aaggaatctt aatctgtaca gggaggtttc 879961 ctgaatgaaa atttatgtag tgtatgatag tgaaggcgaa catactaaag tgcttgcaga 880021 agcgattgct gaaggcgcga gagaaaacga cgcggctgaa gtgttcatcg accatgtaga 880081 tcaggctgat atccgcaagc ttaaagatat ggatgcgatt atttggggat gcccagggca 880141 tttcggaaca atcagctccg gtcttaaaac ttggatcgac agacttggct acttgtgggc 880201 tgaaggcgag ctgatcaaca aagtcggtgc tgtcttctgc acaacggcaa caacacacgg 880261 cggcttggaa atgacaatgc acaatttaat cacgccgatg ttccaccaag gcatgattgt 880321 tgtcggactg cctggcaacg tgcctgaaaa cgcactttat ggctcttatt acggagcagg 880381 tgtcacttgt ccggtagaca gtgatgagtt aatgtctgag gaaggtattc agcttggacg 880441 cgcgttggga agacgtgtca gccaagtcac aggaaaccta acagcaggac agtaaggaga 880501 ggttgaaatg gccattatta tagcaataat tgctgctgtc attgtcattg cggcccttat 880561 tacatttaac gtccgcaacg cctcacctgg acctgagaag caagaagcaa ccgatagaat 880621 cgcacctcca gaagaggaaa aaaacgaagc gcattaccct gctgaagcaa gggctgccga 880681 gcatacgcca tccgttgtca aaaacgattc tccaaaagag aagcgtgaca caatgggtga 880741 tgatatttac aggcaggcgc tgcaaaagtt taagcattct gatgaagttc atgcagaaga 880801 agaggtcact gaggaaagtg acaaaatgca ggaccgcagc tatcgtgatg cgctgctctc 880861 tatgaaaaat aagaaaaagt aatgaaaaag gcaaatccgt ttactcatgc gggtttgcct 880921 tttttgctgt ttccatcaat tatgttttta tcaaataaat ccatggaata tgttgtattc 880981 caccttgatc tagtgtacta tgttactcat acaccgagga ttttttccgg gaggtaaaga 881041 catgaattct tttttaggtt tattaaagaa agatatcaag ctttcaagaa tgtggctgct 881101 agtatggata tgcggaatca ttttcttatt gggaacaggc catattatag cttctcgcac 881161 gaaagaacct ctagtcattt ttggtttttt tgttgcagtt gctttttttc tgcttttctt 881221 atctcctgtt tttgtttttt atcaccttcg caaggaaggg aaatcacagc tttggctgta 881281 caatccaaat ggcggcttat ggctgttttc ttctaaattg gcagcatctt tgctctatca 881341 atttgtgatt cagttggcat taacagccta tggcatatgg atgtatcata tgctctctgt 881401 aaaaaatctg ctggagcatc aagttgatat aacgagtaca gtggctttgc tgaatatgta 881461 tgggcttatt tcttcgttag atatgtcagt aacagtcatt gtgttttgga ctgtttttca 881521 ctctctcaga aattggcgcg gaatgcggtg ggctgcgatg gttctgttgg tcgcaatgtg 881581 gttattcttc gatgaataca tcataagccc tttggttgaa tctcaaaagc atttctggcc 881641 tgtaacagtc tattgcaatt ttgatttcca cttccacaat gtttggagat tggaactaaa 881701 acctatccat ctgtctgtgc tagggtttcc tattgctata gtcatcacat tcttgctgct 881761 catcatggct tcaaaactgc ttgatcgtaa agtagaggtg taaatatgga caatcaattc 881821 caatcctcga aaccgattta tctgcagatc gctgatcaga tcttttatag gctggtcagg 881881 aaggagctgc tcccaggaga caagcttcct tcagtaagag aaatggcgat tcaaactaaa 881941 gtaaatccca atacaattca aagaacttac agtgagatgg aaaggctggg tattgtggag 882001 acaagaagag gtcaagggac gtttattgcg gaaaaagcag aaatcgtaga cgagctgaaa 882061 gacaagctga cacgagaggt gctggaaggc tttgtcaagc aaatgaaaga gctggggcta 882121 acgaaagaag aaatgttaga agggattaaa acattcacag agggaggcta aaatggaaat 882181 caagctagaa catgtatcaa aaaaatacgg ccgccatacg gccgtcaatg atgtgtcaat 882241 caccctatca tccggacgga tttatggcct gattggaccg aacggcagcg gcaagtcaac 882301 gaccctgaaa atgatggctg gccttctgtt tccgacttca ggatttgtaa aagttgatga 882361 agagcaggtt acgagagaaa tggtgcgtca aacggcttat cttactgagc ttgatatgtt 882421 ttatccgcat ttcactgtta aagatatggt gaatttttat cagtcgcagt ttcctgattt 882481 tcatacagaa caggtttata agctattgaa tgagatgcag ctgaatccgg aaaaaaagat 882541 caaaaagcta tcaaaaggaa atcggggcag gctgaaaatc gttcttgctt tagcgagacg 882601 ggcagacgtc atcttgcttg atgaaccttt ttccgggctt gatccgatgg tcagggattc 882661 catcgtaaac agccttgtgt cgtacattga ttttgagcag cagattgtcg tgatcgcgac 882721 acatgaaatt gatgaaattg agactttgtt agatgaagta atcatcctcg ccaatggaga 882781 aaaagttgcg cagcgtgaag tagaagatat tcgtgaacag gaaggcatgt ctgttttgca 882841 atggtttaaa tcaaaaatgg aagtttgcta gaaagaggag gaatatgatg aaaacagtgt 882901 tggaattgaa aaacgtgact aaaaacatca gaggccgaac gatcattgat gatctcagtt 882961 ttacgattcg tgaaggcgag gtattcggtt ttttaggacc aaacggagcg gggaaaacga 883021 caaccatccg gatgatggtg gggttaatga agctgtcgaa aggtgatgtc ctcatttgcg 883081 gccaatcaat tacgaaagaa tatgccaagg cgattaagca tatcggagcg atcgttgaga 883141 atcccgagct gtataaattt ttgagcggat ataaaaatct ccagcaattc gcaaggatgg 883201 tcaagggtgt cacgaaggaa aaaattgatg aagttgttga actggtcggt ttaacagaca 883261 gaatccacga caaggtgaaa acatattctc tggggatgag acagcgtctt ggcttggcac 883321 aatgccttct gcacgatccg aaagtgctga ttttggatga accgacaaac ggccttgatc 883381 cggcggggat cagagaaatc agagatcatt taaagaagct gacccgagaa agaggaatgg 883441 ctgtcatcgt ttcaagccac ctgctgtcag aaatggaact gatgtgtgat cgaattgcga 883501 ttctgcaaaa aggaaagctg atcgatattc aaaatgtaaa agatgaaaac attgatgaga 883561 atgatacata tttcttccag gttgagcagc cgagtgaagc cgctactgtt ttaaatcagt 883621 acgatttgct gagtaagaca aatggtgtag aaatcaaact ggctaaagag gaagtccctg 883681 cggttattga attgctggtg atgcagcaaa tccgtattta tgaggtcaag gtcataacaa 883741 aatcattaga ggaccgtttc ttagaaatga caggtgaaac aaaagaggag gttcagcatg 883801 cttaatttga tttataatga gtggctcaaa attttcagcc gtgccggaac atgggtgatg 883861 atcggaattc tggggctgac aatggttgga tttgcatttt tggcgaatca tttttctgcc 883921 ggtgaatcaa attcccattg gaaacaagag cttcaagcac aaaacgccga attaaagaaa 883981 gaaatcaaag aagatccttc actgaaagat gggtataaag aaacaatcac actcaatgac 884041 tatcgcatcg agcataatat ccctagtgac acgggctata cggtatggtc ttatgtaacg 884101 gattcagcaa actttaccat ccttaccggt ctgtttacta ttatcatcgc ggccggaatt 884161 gtcgcgaacg aatttaattg gggaacgatt aagctattaa tgattcggcc gctcagtcgt 884221 tttcaaattt tgatgtccaa atatattaca gttctcctgt ttgggctcct gttgctgttg 884281 attttattta tcggttctac tttattaggg ttgatcttct tcggaacggg tggtgaaacc 884341 gccgcgaata ttcatttaat ctataaggat ggccatgtca ttgagcaaaa catgatgggg 884401 catttggcta caacgtatct ttctgaatcc gtctcggctt taatggtggc gacgatggcg 884461 tttatgctgt ctgcggtatt cagaaacagc tctcttgcgg ttggtttttc catcttcttg 884521 ttggttgccg gtacgactgc aactgcattt attgcagcga aatttgactg ggcaaagtat 884581 atattgtttg ctaatgtcga cttgactcag tatgtggatg gcacaccgtt aataaaaggg 884641 atgactatga cgttttctct cgtcatgctg gcgatctact ttatcatctt cctgttgctt 884701 gctttcggaa tcttcatgaa gcgggatatt gcaaactaat aaaaaaagct gttttgctta 884761 tgcaaaacag cttttttgtc aaaataaaaa ctgcaggttt gcacctgcag tttttcatat 884821 caatttatgc ttacgcttct ttagtaacgt tagcagcttg tggtccgcgg tttccttcaa 884881 cgatttcaaa agaaacagct tggccttctt ctaaagtttt gaagccttcg ccttgaatag 884941 cagagaaatg aacgaataca tcgtcttgac cttctacttc gatgaatccg aaaccttttt 885001 cagagttgaa ccattttact ttaccttcta acatgaaatt tcctcctaaa gcgatcataa 885061 cgcttaaatt cactattctt gctcttaaca aactttcaag acgaaaactc ttacaaaact 885121 ttcttcttaa agatagttcg aacaaaaata attaccttta ctctaccagt aatcttcaga 885181 aaaaacaact gcttattgaa atttttttcg gaaaatacca tatttatttt tcaatttgat 885241 atttatttac ggaaattcat ctgttttctc gatatgtgat catacgtttg ccttagtatt 885301 ccttcatttt gggaagataa gtaataggaa ttgacaacct tattggatat gagtaaggta 885361 aaagttaatc aatattacaa atgacaacgt ttatcaacta agagagcgta tgatttttat 885421 gtctgatatt gcttgcatgc tctaatacat agataggagt atggtcacaa tgaaaaagtg 885481 gcttatatgc agtttcgtcc ttgttcttct cgtttcattt actgcatgtt caccgtctgc 885541 agaacatgaa tcgataaaaa tcgggattgc tgagtctgac ggggcaatat ggaactatat 885601 tgctcaaaag gctgaagagg cagggctgga tattcagctg atcccttttt ctgattatgc 885661 ggagtctgat atcgcacttg ctaacaaaga aattgatgcc aacgcctttc aaaccatttc 885721 atattttcag tcgttcactg aaaaatacaa acttaatttg gcaccgctcg ggacgacata 885781 cataacgccc atgggcattt attcaaaacg atatgaacga atccgagata tatcgcgggg 885841 agctgtcgtt tctgttccgg ataaagcgtt cgattttggc agggcgctta cggtgctcca 885901 ggaagcgggt ttgctaacgc tgaaaaacgg atttaacgga acaggttcag ttgatatgat 885961 taaagataat ccgagacacc tgaaattaaa agctgtccgg caacaggatg cagtgagcgg 886021 tgccgacgtg tttgtcatga aaccatcaga agcaaaaaaa gcgggcttga acccgaaaaa 886081 gcatacgcta aagagcggcg gactcatgtc tgaggaagag atgaatttga ttgttgtcag 886141 agcggaggat caagatcggg aagcgctgca aaccattctt gagctttatc aagctgatga 886201 tacagcggca tttatagaaa aagaatatca gggagatctt gtcccggctt ttctgccttt 886261 gaaacgtctt tcagattgga agaatgaatt cgaacattga attcattctt ttttttctga 886321 aaaacacact ctgttccgtc ccgtttcttt cgctttgtaa agcatttgat cggcaagaat 886381 gggcaaggat cctggctgtt ccgtattatt ggggtaatga gcggccccta gtgatatcgt 886441 aactgaaagc tcgtcgccgt ttgttaatac aatcggtgca tcacttacag tgctcctgat 886501 ccgttcagcg atccgggctg ctttatcaag agaacagttc ggcaggagca cggcaaattc 886561 ttcaccgccg atccgagcgg caggatcagt atttcggatg gtctgcttca gacgtaaccc 886621 tagctctttg agcacctgat ctccttcatg atggccatat tggtcattga tggtcttaaa 886681 atgatcgata tccatataaa tcagtgcaaa ttgaaaatgc ggggtatcgg ccgcctgctg 886741 atacagagct tttgtggttt cttcaaattt tcttcggtta tacacgcctg ttaaaaagtc 886801 aaagtgcgcc tgaaacttat attgtttaaa aagaagatgt gcatttgttt catgatcaat 886861 aatatataaa ctgagcatgc cgcccgctat tgatatgatc caaaaataca aatgaagttc 886921 gtatgaatgt aaatctataa gaaaataaaa ggaaaaggag atcaagctat ttgtgattat 886981 taaaagatag aaagcatgtt ttagttgaac tttttttctt ctagaaacaa tgagtgacgg 887041 aatggcagcg atacaaatga taataaccga gtatagtgca gatgtgttca tcgtaatcag 887101 caagcggcct gcagtgatca tggccagggc cgttgccgtt gaaacccagc ctccataaag 887161 agcggcaatc ataataggga tatttcgaag atcaataatt gaatgctgat aggtaaatcc 887221 aaaaaccatc agaataaccc cgagcaaacc gcaggccagt cctttaacag cttgaaagga 887281 tatgctgtct tttttatgta ctagcctttc tttaaacagg tgggtgaaga gataattaaa 887341 tgtgattaaa atggtcaaat ttacaaacag ttctttcagc aaatattatc acccttatat 887401 aaggtactaa agatggaagg gaaagaaaag aacaaaaaag gcattatata aggttttttt 887461 acttgaattg ataagttaaa ataattcgca cttgacccat cggaattagt gtaatatagt 887521 aaatgagaaa atttgaaggg agagtttacc tgctttggag actttactgg ttgtattaca 887581 tgtatttatt ttatttttac ttatcttagg gctctttgtt atgcagaaaa aacatgtttc 887641 cttctctaaa cgtgtattta ctgcgctggg gctggggatt gtattcggat ttgcgcttca 887701 gctgatttac ggcccgactt caaatatagt cattcaaaca gccgactggt ttaatattgc 887761 cgggggcgga tatgtcaaat tgcttcagat ggttgtcatg ccgctcgtct ttatttcgat 887821 tctcggcgcc tttacaaagc tgaagctgac aaaaaatctt gggaaaatca gcggtttgat 887881 tatcgggatt ttagtagcaa caacagcagt tgctgcagct gtcggtatcg cgtccgcgct 887941 ttcatttgat ctgcaggcga ttcaggttga ccaaggaagt acagagcttt cacggggaca 888001 ggagcttcag cagaaatcag aggatatgac agcgaaaacg ctgccgcagc agattgttga 888061 actgctgcct ggaaacccgt ttttagattt tacgggagct agaccgactt caacgatcgc 888121 tgtcgttatt tttgccgctt tccttggagt ggcattcctc ggcgtaaaac acaaacagcc 888181 ggaacaggca gaaacattta aaaaactggt tgatgccgtt tatgccattg tcatgcgtgt 888241 tgtcacactc attttgagac tgacgcctta tggggtgctg gccatcatga caaaaacaat 888301 tgcaacgagt gatcttgaca gcattctaaa actgggcatg ttcgtgattg catcatatgc 888361 cgcgttaatc actatgttta tcattcattt gctgctgctg acgttcagcg gcttgaatcc 888421 ggtgatttat ttgaaaaaag cggtgcctgt acttgtattt gcatttacgt caaggtctag 888481 cgcaggtgct ttaccgctga atattaaaac acagagaagc atgggtgtac cggagggaat 888541 cgcaaacttt gccggttcgt tcggtctttc gatcggccaa aatggatgtg ccggcattta 888601 tcctgcgatg ctggcgatga tgattgctcc gactgtcggc caaaatccat ttgacccggt 888661 gtttattatc actgttatcg cagtcgttgc catcagctcc ttcggggttg ccggagtcgg 888721 cggcggagcg acattcgcgg cgcttcttgt tttatcatca ttaaacatgc ctgtcgcgct 888781 cgccggtttg ttaatctcaa ttgaaccgtt aatcgacatg gggcgtactg ctttgaatgt 888841 cagcggaagc atgacatccg gtcttattac aagtaaggtc acaaaagaaa ttgatcaagg 888901 ggcatttcat gatcaatcca gagtgattga agctgaagaa gcgtaacata tgaaaacgtg 888961 taatccaaga ggattacacg tttttttaac ggccaggctc taagtcctcc agcatttcca 889021 tcatcgtgtt gtcgtccatg acattcattg cgttttgttc aaaatgaatg ggttcagcat 889081 aatgcggctg tctttttttc gcggctgtct cagtttgcct agtttgagac tgtgtatgct 889141 gatgctgtgg ttgctgctgt ccagcgtgct ggtgctgacg gccattttgc cgctggcttt 889201 gatgctgcga acggtcctgg ttatcaccgc tgcttccgct gcttccgcta aatgcttgtt 889261 tgaccatgtt tcctacatta gaagcatcaa acgtgttatt ttctgaattt cgtctgttca 889321 tttgtcctgt gataaacccg ctgattcttt ggcggatctg aggtgataat gcagtaataa 889381 gcatagttga tcctatgatc aatgctgcgg ggctgattcc tcttcgctgg ttgaacaaca 889441 tgatccctcc tttgcagtgt attcatattt tccccctcgt tagacaaatt aaccgttata 889501 tttcccggga aagcatttcc tccagatttg catgcataat taaagccagt tagaaaaacc 889561 tataagtaaa gtgataaagg aggaattcac atgtttggaa aaaaacaagt ccttgcgtct 889621 gtgcttctta tccctttgct tatgactggc tgcggtgtag ccgaccaagg tgagggcaga 889681 cgtgataata atgatgtaag aaacgtaaat tatcgaaatc cggccaatga cgatatgcgg 889741 aatgtaaaca atcgggataa cgttgacaac aatgttaatg ataatgtcaa taacaatcgt 889801 gtaaatgacg ataataacaa cgaccgaaaa cttgaggttg ctgatgaagc agctgataaa 889861 gtaacagacc taaaagaagt aaagcatgcc gatatcattg tggctggaaa tcaagcctac 889921 gttgcagtcg ttttaaccaa tggaaataaa ggtgcagtag aaaacaatct gaagaaaaaa 889981 atagccaaaa aggtaagatc tactgacaaa aacattgata atgtttacgt ttcagctaac 890041 cctgattttg tagagcgtat gcaaggatat ggaaagcgta ttcaaaatgg tgacccaatc 890101 gccggattat ttgatgaatt tacacaaact gtacagcgtg tattccctaa cgctgaataa 890161 atgaaagaag ccgcacaatt tgtgcggctt tttctttgcg ttaatgacac actgcgaact 890221 caggctgcat agagtaaaaa taaaaaggta caagacggac cggctcaggg agggagacgt 890281 ttgcgggatg gcataggaaa gcgtgcggca tccgctctat tcctgtgcgg agtccttgtg 890341 atgctggctg taagctcagc catcgtatca agcgcgatgt atatcctgtc ttttccaggt 890401 caggcatctg gaataacaaa agaacaagtg acgaagcaca tgaagaaaga gtcattcaaa 890461 caggccgata tttattacac ttctaaggaa aagtccttac tgccattgac gaaagaaacg 890521 cttgaatatg cggtcagtat taatcagatt atgattggat attcgaatca aaagcctatt 890581 gacattattt tttttcctaa tgaaaaacag atggaggctt actccggttt attggatgta 890641 gttggttttt attctgaacg ggagcagctg atcggattgt tgcctgaaga gaaaaagaaa 890701 ctgttagaag gggacgaggt agcggtttat ttgtaccaga gattgttgat tcatgaatac 890761 tcgcaccatg cgtttcacca gaaattgaag gagcttgaga cggatcccga tgagtttccg 890821 ttatggtttc atgaagggtt aagcgagtgg attgcgaact atgaattgct catagatccg 890881 atcacgtttt ctgtcgtgcc ctttgaccgt ttgcagactg atcgagactg gcaggaagct 890941 agagccgaat atgacactga tgtctatttg caaagctttt atatgatcga tgagctgacg 891001 gacaaatacg ggaaagacat tatttcagaa atgattaagg aaacggcaaa aaaaggggac 891061 tttgaaaaag ggtttaaatc agcaacaaag gaaagtcttg atcaatttga aaaagatttt 891121 aagaaaaaat ttgaaaaaaa cagtgcggca ttggatagta tctatccaat gcctttgtta 891181 ttagtgaagt ccttgctgac ccattccgcc ttgtgtcgga ggcatttgtc cttgggcagg 891241 ggcgaatgaa tttcgcagct gttccatatc ctgcgcatca agctgaggaa cctggtaata 891301 gccgtgtttg ttttggtata ggaaaatttc aaatgccatt tcaacatact cctgaatttg 891361 cgcagacagt acgcgtctta cggccggatt tgtcatttcc agagaagcca tcgtcagcat 891421 agaagcttgt gctttaatcg cgcaaagcat ttgtcggctg atgatgctgt catcaatatc 891481 attcatggat tgaacaggtt ttttaggctg tgacggctgc atgccgtaaa cagtctggtt 891541 gtcttccttc atcatataag ttgctgtttt ttgtgaaggt tcgcttcctg ttttgaagca 891601 ttctgcagtt atattgtatt gagatgtgat gaattgatgt tgacgatcaa ggatgtttag 891661 taattcttga tccttacaga attgtctcag catcataaac tgatcaagca cagtaagtgt 891721 tccggaaagc acctcatgca tatcaaacat ttcatgtccg ccgtggtttt tatgcggttt 891781 gccaggaata cctttgttca tttgggattg ctgctgctga ttgaactgat ccaaaccgaa 891841 ttcctccttt tttttcagat cagctgtatt ttgtgtcagt ctgccgtgta ttatgcagaa 891901 gcctgaaagg aattatatgc tgtctgtcga aatgataagc agacaaaatc gttgtcatta 891961 tgtgtataag ggaggaaata tgatgaggcg tattctgcat attgtgttga tcacggcatt 892021 aatgttctta aatgtaatgt acacgttcga agctgtaaag gcagctgaac cgcaacagcc 892081 tatatcgatt gagaaggcaa tacagcaaaa agaaggacag gcacttgtcg aaggatatgc 892141 agtcggccag gctgtttccc cgcagcatta taaactgaca agcccttttt caaatgatta 892201 taatgttgcg ctggcagacc gtaaaaacaa aacatcgccc gaacacatcc ttcctgtgca 892261 aatcccctcc gccttcagaa gccaatttgg gctgcaaacc aatccgcttc ttcttgggaa 892321 aaagataacg gttcaaggaa agcttgaaaa ttactttaac acgacaggac ttaaaaacgt 892381 tcagtcgatg aacgtaaccg atgacacaaa aactccgccg gctgaacagc aagtgaccat 892441 aaatgaagca cggggaaggc tgaatgaaga agtaacgata aaagggatca ttacagctga 892501 tcaaaacgca atcggaggcg ggaagctgtc gacctttttg caagatgaaa ccggaggcat 892561 taacatttat tcgccatccc ctgaacaatt tcccgaatta aaagagggta tggatgtcac 892621 ggtgacaggg aaaatcacgt cttaccaggg gctgaaagaa atcgttccaa actcatcagg 892681 catcaaaatc aaccagtcaa atcaatccct ccccgccccc aaacacttaa caatcaatga 892741 acttattaac ggcagcctag gtgatcagta tgaaggacgc cttgtgaaac taaccgcttt 892801 tgtttcctca attccaagtt ctcctgccgg cggcggttac aatgtaacaa tgattgatga 892861 cgaccatcat gcaatgacgc tccgggttat gaatgaaaca ggggtgataa acgagcttga 892921 tgagggcaaa tggtatgaat ttaccggtgt gttaagcaga taccaaacct ttcagctgct 892981 tccgcgaaaa tcggctgacc tgaagctgct tgaagagcag cccgcacctc cgtctgcaga 893041 gggagaatat gaagggattg ttgaccgggt agttgacggc gataccattc atcttaaatc 893101 tccggtgctt ggaacgacaa aaatccggtt tgtaaatgta gatgcacccg aaacatatca 893161 cacaccaaaa aatgacgcag atgaaaatca attaagattt ggcaaaaaag catctgacta 893221 tctaaaaacg gttctgtccc cgggtgataa aattactgtc aaggtcggga gtgaagccaa 893281 ggacagctat ggcagattgc tcggacaagt cataaccgaa tcaggttcaa acgtgaactt 893341 agagcttgta aaaaacggct atgctccgac gtattttatt tggccggttg acaatgaaga 893401 ggattatcag caatttcagg ccgcagtagc cgctgcaaaa aaagatcaaa aaggaatttg 893461 gaatgaaaac gatcccctca tggaaatgcc gtttgaattc agagccagag agcaagggaa 893521 aggcctgaca agatatgtgg gggactcgtc gaataaaaca tatgtgcagc cagctgactg 893581 gaagaagata gctgtggaaa acagaatttt cttcgcctca gcaagtgaag cggagagcgc 893641 gggatataaa aaaaggcaaa cggcacctca agaacatgtg ccgcttagaa ttctcagcat 893701 gaatgatttg catggcaaaa tcgatcagca atatgagctt gatcttgatg gaaatggaac 893761 tgtagacggc acgtttggac gcatggatta tgccgccgca tatttaaaag aaaaaaaggc 893821 tgaaaagaaa aactcgctga ttgtgcacgc gggagatatg atcggcggaa gctctccagt 893881 ttcctctctt cttcaggatg aaccgactgt agaactgatg gaggacatcg gatttgatgt 893941 cggaaccgtg ggaaaccacg aatttgatga aggcacggat gaacttctga ggatcttaaa 894001 tggcggtgat catccgaaag gcacaagcgg atatgatgga cagaactttc cccttgtatg 894061 tgccaattgt aaaatgaaat caactggaga gccctttttg ccggcttacg acatcattaa 894121 tgtggagggc gtacccgttg cttttatcgg agttgtcaca cagtcggcag ctggcatggt 894181 tatgcctgaa ggaataaaaa atatcgagtt tacagatgaa gcaacagcgg tgaataaggc 894241 ggccgaagag ctcaagaaaa aaggcgtgaa ggccatcgcg gttctcgcac atatgtcagc 894301 tgaacaaaac ggcaacgcca ttaccggtga gtctgctgat cttgcaaaca aaacagattc 894361 tgaaattgac gtgatttttg ccgcgcataa tcatcaggtt gttaacggtg aagtgaatgg 894421 aaaactgatt gttcaagcgt ttgaatatgg aaaagcgata ggtgtcgttg atgtagagat 894481 cgataaaacg acaaaagaca ttgtcaaaaa gtccgcggaa atcgtatatg ttgatcaaag 894541 taaaatcgaa ccggatgtca gcgcgtcagc cattttaaag aaatacgaaa caattgcgga 894601 accgattatc agcgaggtag tcggcgaagc cgctgttgat atggaagggg ggtattcaaa 894661 tgacggcgat acacctcttg gaaacctgat tgcggatggt atgagagctg ccatgaaaac 894721 ggattttgcc cttatgaatg gcggcggcat acgtgaagcg ctgaagaagg gtccaattac 894781 gtggggagat ctttacaata ttcagccgtt tggaaatgtg ttaacgaagc ttgagattaa 894841 aggaaaagat ttaagagaga ttatcaatgc gcaaatctcg ccggtttttg ggcctgacta 894901 cagcatcagc gggtttacgt atacgtggga taaagaaacc ggaaaagcag ttgatatgaa 894961 aatggcagat ggcaccgaga tccagcccga tgccacatat acattgaccg tcaacaactt 895021 tatggcgacg gcgacaggag ccaaatatca gccaatcgga ctgctgggaa aaaatccggt 895081 gacagggcct gaggatttgg aagcgacagt tgagtacgtg aagagttttg atgagccaat 895141 tgcgtataca aaagagggaa gaattaagct tgctgaagcc agtgatattg aagaccctgt 895201 aacagaagac ccgataacgg aagagcctgg agatgatccg gggacggagg atccgattaa 895261 agaggatcca aggccaggtg aagatttgcc tgatataaaa gaaactccgg gaacagcacc 895321 ggttcatcag cttccgcctt cagccatttc gagattcaat gaaataccaa tcaacaacac 895381 aaaaaccgct gatactgcta atagcatcag cacattgccg ttacaaaccg agactgcgga 895441 aagcgggtct gatcatcagc ttccggatac gtcagcgggc tactataact ttatggtaat 895501 cggtgcggcg gtgacattgt caggaactta tctatatgtc agaagaaaaa ggagcgcctc 895561 cagaacgtga aaaaagttat tccactattc atcattgctg ccggcctagt gatcgcaggc 895621 tatggaggct ttaaattgat cgatacgaat acgaaaacgg aacagacatt aaaagaagca 895681 aagctggcgg ctaaaaagcc gcaggaagct tcggggacga aaaatagcac agatcaagca 895741 aagaacaaag catcatttaa gcctgagacc ggccaagcga gcggcatttt agaaataccg 895801 aaaatcaatg cagagcttcc gatcgtggag ggcaccgatg ctgatgattt agaaaaaggt 895861 gtcgggcatt acaaggacag ctattatcct gatgaaaacg gacaaattgt gctgtcaggg 895921 catcgggata ccgtgtttcg ccggacggga gagctggaaa agggggatca gctccgtctt 895981 ctcctgtcat atggagaatt cacatatgaa attgtaaaaa caaaaattgt cgataaggat 896041 gacacatcta ttatcacgct ccagcatgaa aaggaagagc tgattctgac gacctgctat 896101 ccgttttcat acgtcggaaa tgccccgaag cgctatatta tatatggaaa acgagtgact 896161 taaaaagccg aggcagtgcc tgcggctttt cttcatgaaa aatatgtgcg gcaaaggttt 896221 ttcatatcag cagggaaagg ggcttcagca actatgagct cgtctgttat cgggtgaacc 896281 gcttgtactt tattggcgtg cagtgcctgc ctgtttagca gcttgctccc gcctccgtaa 896341 agcgagtctc ctgtcaacgg atggccgagg ctcgccagat gaacacggat ttggtgtgtt 896401 ctgcctgttt ccagctctaa ttcaacgagc gacagccgtt ctttcgcatt gctggccatt 896461 accttgaaat gagtgacggc tgtttgcccg cctggtgaaa cccggcgtct tgtcgggtgt 896521 gagcggtctc tgccgatcgg tgaattaatt gtcccttttt tcgtccgtag cttaccttca 896581 gcgatagcgg tatacgtacg cttcagcgtc tttttctcta actgctggtc taagatggcg 896641 tgtgccaaac gatgcttggc aaaaacgata gcgccagatg tatcctgatc aagacgatgg 896701 acgtggcgca ccttacatgt ttcgccattt atctgataat gatacgcgat caaattagcc 896761 agtgtgccgg tttgcccatc ctcattcgga tgcgtcgcga tgccagcggg tttattgatg 896821 atgagcatat gattgtcctc aaataaaata tcaagctcgc catactccgg aatgaccgaa 896881 gatgcttcac tttcctgaag atcaatgaac acgcggtctc ccttttttac aatcatattg 896941 tttaagacgg attcgtgatt gacctttatc tgttgatggg acatccagtc ttgtatcact 897001 ggtttagaag ctttgagcgc tgttttgagt acggaaaaca gccattggcc gtcctgtttt 897061 tcattgatga ggatctcaag ccctctgcct ttttggttca tgttaaatgg ctccttttcg 897121 aagcggaagg ctgctgtttc tcataggaaa cacttacctt agctttcgcg tttttttctg 897181 tgctattctt gagtaagact taggatattc gatggcaaga aaggtgattg acgtgagaat 897241 tgtgaacgca gcaactgcag aacaggagag ctttatcaag gagctgtcta tggagctgat 897301 ccatgatgta tttcctcttt atttctccga actggacatt cagcgcttta aaaagaaagg 897361 cgttctgtct ttaaataacc attattacca aggaacatta aaagaagcat ttcaaattat 897421 ggcttgtctg caaatgatac atattatcct gaccaagcct tcgccgcact ctgatttgag 897481 tgatcaggcg atttttgaaa aaaacagcaa gatgctgaat gattttggga tttattttcc 897541 gtttgctttt tctgactttc aaaagaagac taacaaagcc tttttcggtc aaagaaggct 897601 gatataatca tgcggcaagg gcttttctat ttttagaaaa gctctttttg tatcagagaa 897661 atcatatcat aaaacctttc ctctaactcc ctttttaaac ggctcgtgtc tgaacatact 897721 aatgattgaa aggggtgctg acaatgagtt cagttaaaga tacaatgaca acgcaggtgg 897781 caaccgtttc tccgaatcaa acgattcagg aagcggcttc tctaatgaaa cagcataacg 897841 tcggggcgat ccccgttgta gagcaaggtg ttttaaaagg aatgctgact gaccgtgaca 897901 ttgcattaag aactacagct cagggccgtg atggccagac acccgtttca gaagtgatgt 897961 caacagaact cgtatcagga aaccctaata tgagtctgga agacgcgtcg cagctgatgg 898021 cccagcacca aatccgccgc cttcctattg tagatcaaaa caatctagtc gggatcgttg 898081 cgcttggaga cctggcagtc aatcagatgt cgaacgagtc tgcgggatca gcgctgacaa 898141 acatttctca ccaaaacatt cattaataag aaagagcttg cagtgtgcag gctctttctt 898201 cacataaaac cttacttttt gaaagcagac ttgtttcggg gtatagtgag tgtatacata 898261 tgtctcaatt cgtactaaag gagttgtacc cagtgattaa agcgttaatt tttgattttg 898321 acgggcttat tctagataca gaaacacacg aatatgaggt tcttcaggaa atatttgaag 898381 agcacggctc agtgctgccg ctatctgtct ggggaaaggt catcggaact gctgcgggtt 898441 tccggccttt tgaatattta gaagagcaga tcgggaaaaa gctgaaccat gaagagctca 898501 cacaattgag aagagagcgg tttgccaaac gcatggaatc agaaaaagcg agacctggtg 898561 tcgaagcgta tttgaatgcg gcaaaggatt taggcttaaa aataggcctt gcctccagct 898621 ctgattataa atgggtgtcc ggccatttga agcaaatcgg cctgtttgat gattttgaag 898681 ttattcaaac ggcggatgat gtggaagagg tgaagccgaa tcctgaactc tatttattgg 898741 cggcaaagaa cctgggggta tcgccagcgg aatgtctcgc gtttgaggat tctgtcaatg 898801 gttcgattgc tgcgaaacgt gcaggcatga agtgtgtcat tgtcccgaat aaagtaacgg 898861 gtaccttgat gtttgaagac tatgatcaca ggcttgaatc aatggcggag atggagctcg 898921 ccctattgct tgatcatctg aactcacaaa actagaaagg agcgagtagg ttgtctgaga 898981 aattagattt gacccggttt gaaaagaaaa tggttatccg caatatcgaa gagaaagaca 899041 tcgacaagat tatcgatctt caaaaggact gctttccagg aatggagcct tggaagcggg 899101 agcatttaat cagccatttg gagcattttc cggaaggaca gttttgtgca gaattcgaag 899161 gtgaaattat cggttcgtgc tcaagtctcc tgattaactt tgatgaatat gatgaccgcc 899221 atacgtggca ggacattaca gatgacggtt atatcaccaa ccataatcct gacggcttga 899281 atatgtacgg aattgaagtc atggtgcacc cgaaatacag acgaatgaag atcggccacc 899341 gtttgtacga ggcgagaaag gacttagcca gacgcttaaa cctgaaaagc atcatcatag 899401 gcggacggat tccaaactat cacaaatatg cagaggaaat gacagcgaga gagtatgttg 899461 aacaggtgac acgccaccaa atttacgatc cggttctttc ttttcagctg atgaacggct 899521 ttacccttat gcgaattaac ccgaactatc tcccggatga tacagcttcg atcaagtatg 899581 cgacgctgat ggaatggaat aatgtcgatt atctaccgca gcagacaaaa cgctattata 899641 aatcggcgtt ccctgttaga atttgtgtga tccaatacga aatgaagaaa atttattcct 899701 ttgaggaatt tgcgaatcaa gtagaatact atgtcgatgt tgcttccgac gcaagatctg 899761 attttgcggt gttcccggaa attttcacaa cccagctgat gtccttcctt gaggaacggt 899821 caccgagctt ggcggtgcag agaattaccg agtatacaga agattacatc agcctgttta 899881 ctgacttggc tgtgaagtat aacgtcaaca ttatcggcgg atctcatttc gtcgaagagg 899941 aaggcaagat ctataatatc gcttacctgt tcagacggga cggaacgatc gagaagcaat 900001 acaaactcca tattacgccg aatgaacgca aatggtgggg gatcagcgca ggagaccaag 900061 ttcgcgtgtt tgatacggac tgcgggaaaa tcgcgatcca gatctgttat gacattgaat 900121 ttcctgagct tgcccggatt gcggctgata aaggagccaa aatcatcttt acgccatttt 900181 gtacagaaga ccgtcaaggc tatctgcgtg tcagatactg ttcgcaggct agagcggttg 900241 aaaatcaaat ttatacggtt atctctggaa cggtcggaaa ccttccgcaa acggaaaaca 900301 tggatatcca atacgcccag tcaggcatct ttgccccgtc tgattttgaa ttcgcccgag 900361 acggcattgt cggcgaaaca aacccgaata ttgaaatggt cgtcatcggc gatgttgacc 900421 tggaaattct cagaagacag cgccaaaacg gtacagtgcg ccagctaaaa gacagacgac 900481 gtgatattta tcatattcaa tataaaaaat aattcccaaa aaacccgcct gaattggcgg 900541 gtttttttaa acaaaagcgg aattgtttag gtgctttctt taaaataaaa gtaaattgta 900601 tagtggatgt gccttatgga gtttctgtat tttcgccatt tcctatatca tacagaaaac 900661 ggctaggctt cacattgcta ttgcaatggc tgtccaagtt gtttcgagtg cgacctttat 900721 cagtacgatg ctgagcattg tcactttgcc tgttttgctt tggaagctgc atcctctttc 900781 ttcttgagaa aggggatgtt ttattattta cgcggtttat tgactctgac ccggtctggc 900841 tttatattga aggcagggaa atcatcacca agacatcaca taaagagaag gtctgtttca 900901 attgaattgg cattataggg aacgctaatg aaatggagat gatggggatg gaaaacattc 900961 agcaaaatca gggattaaag caaaaagatg agcaatttgt gtggcatgcc atgaagggag 901021 cgcatcaagc ggacagcctg atagcccaga aggccgaagg ggcctgggta accgacacag 901081 acggacgccg ctatttggat gcgatgtccg gtttgtggtg cgtcaacatt ggttacggca 901141 gaaaggagct tgcggaggct gcctatgagc aactaaagga gctgccttac tacccgttaa 901201 cgcaaagtca cgcacccgca attcaactgg cggaaaagct gaatgaatgg cttggcggcg 901261 attatgttat ttttttttcc aacagcggat cggaagcaaa cgaaactgct tttaaaattg 901321 cccgccagta ccatctgcaa aacggcgacc acagccgtta taaattcatc tcaagatatc 901381 gggcatacca cggcaataca ttgggagcgc tctcagctac cggacaggcg cagcggaaat 901441 ataaatacga gcctttgagc caagggttcc tgcatgcagc tccgccagat atataccgga 901501 atcctgatga tgcagacacg cttgaaagcg caaatgaaat cgaccgcatc atgacatggg 901561 aattaagcga aacgattgcc ggggtcatta tggagcccat cattacaggc ggaggcatcc 901621 taatgccgcc ggacggatat atgaagaagg tggaggacat ttgccggcgc cacggagccc 901681 ttttgatttg cgatgaagtg atctgcgggt ttggacggac aggtgagccg ttcgggttta 901741 tgcactacgg tgtgaagcct gatatcatta cgatggcaaa gggaatcaca agcgcgtatc 901801 tgccattgtc agcgactgct gtgaaacggg acattttcga agcgtatcag ggggaagctc 901861 cttatgaccg tttccgccac gtgaacacgt tcggcggaag cccggctgcc tgtgctttgg 901921 cgttgaaaaa cctgcaaatt atggaggacg aacagctgat tcagcgatcc cgtgatcttg 901981 gagcaaagct tttaggtgag cttcaagctc tgagagaaca cccggcagtc ggggatgtta 902041 gaggaaaagg gctgctgatc ggaatcgaac tcgtcaaaga caaattgact aaagagccgg 902101 ctgatgccgc caaagtaaac caagtggttg cggcgtgcaa agaaaaaggg ctgatcatcg 902161 gcaaaaacgg cgatacagtc gccggctaca acaatgtcat ccagcttgcg ccgccatttt 902221 gcctgacaga agaggacctt tcctttatcg tgaaaacggt gaaagaaagc tttcaaacga 902281 tataatataa aagtgaatta ttaaaggagc acatgatgag ttttcacaac cagccgatct 902341 taccggctat tcgcaatatg aagcaatttg atgagttttt gaacagttca ttctcttacg 902401 gtgttattct tgatattcat ctcggccagc tgaagggcgt gatcaaagaa gcgcaaaagc 902461 acggaaagaa catgatggtg cacgtcgatc tcattcaagg gattaagcat gacgaatacg 902521 gtgcggaatt tatatgtcag gatatcaagc ccgctgggat tatttccaca agatcgaatg 902581 tgattgccaa agcgaagcag aagaaaattt atgccattca gcgcctgttt ttgcttgata 902641 caagcgcgat ggagaaaagc atggagttta tcggcaagca taagcctgac ttcatcgaag 902701 tgcttcccgg catcgttccg tcactcattc aggaaataaa agagaaaaca gggattccca 902761 tctttgccgg gggtttcatc cgtacggaag aggatgtaga gcaggcattg aaagcggggg 902821 ctgtagctgt cacaacatct aataccaaat tgtggaaaaa atatgaaaac tttttgacgg 902881 aaagtgattg acaccgcttt catgcactga tacaattgca ctaggttaat acattgtgat 902941 ggagaactcg gagaccacag cagctcttta cggcaaatgt ttatgcaccc gtaaagcggt 903001 ttgttgtggt ttttttattc tcttcttctc tatcatgctt tttaatcgtg actttaggag 903061 gaatgtgcta tgacagcatt ttggggagaa gtcatcggta cgatgctgct tatcattttt 903121 ggtgcaggtg tttgtgcagg tgtcaattta aagaaatcgc tttcattcca gtctggctgg 903181 attgttgttg tatttggatg gggattgggt gttgccatgg cggcatacgc ggttggcggc 903241 atcagcggtg cccatttgaa tccggcgcta acgatagcgc ttgcatttgt aggagatttt 903301 ccttggaaag aggttccggt ttatattgcg gcgcaaatga tcggagcgat catcggtgcg 903361 gtgattattt atctgcatta cctcccgcac tggaagtcaa cggatgatcc cgctgccaag 903421 ctgggtgttt tctcaacagg gcccagcatt ccgcatacat ttgcaaacgt tttaagcgaa 903481 gtgattggga catttgtcct tgtacttgga atcttggcca taggtgcaaa tcaatttaca 903541 gaaggactta atcctttaat cgtcggtttc ctcattgtag caatcggtat ttctctggga 903601 ggcaccaccg gctatgctat caatcctgca cgtgacttag gtccgcggat cgcccacgct 903661 tttcttccga ttccggggaa gggctcatca aactggaaat acgcatgggt tccggtagtc 903721 ggcccgattt taggcggatc attcggcggt gtattttaca acgctgcatt taaagggcac 903781 atcacaagca gcttctggat tgtaagcgtt atattggttg tggtattgtt aggactctat 903841 gtttatacga aatcacattc tgctaaaaca ttatcaaatt ctaaatatat ttaatcaaag 903901 gggagacatc ttatggaaac gtacatttta tccttagatc aggggacgac aagttcaaga 903961 gcgattctgt ttaataaaga aggcaaaatt gtccactctg ctcaaaagga atttacacaa 904021 tacttcccgc atcctggctg ggttgagcat aatgccaatg aaatttgggg ctctgtcctc 904081 gcggttatcg cctcagtcat ctctgaatca ggaatcagcg cttctcaaat tgccggcatc 904141 ggcatcacga accagcgcga gacgacggtt gtgtgggata aagatacagg aagtcctgtc 904201 tataatgcaa tcgtttggca gtccagacag acgtccggca tttgtgagga acttcgtgaa 904261 aaaggatata atgataaatt cagagaaaaa acagggcttt taatcgatcc ttacttctcc 904321 ggcacgaagg tgaagtggat tttagacaat gtggaaggcg caagagaaaa agcggaaaaa 904381 ggcgagctgc tgtttggaac gattgatacg tggctcattt ggaaaatgtc aggcggaaaa 904441 gcgcatgtga ccgattactc caatgcctca agaacactga tgtttaatat ttacgattta 904501 aaatgggacg atgaactgct cgacattcta ggcgtaccga aatccatgct ccctgaagtg 904561 aagccgtcct ctcatgtgta tgcggagact gttgattatc acttcttcgg aaaaaatatc 904621 ccgattgctg gagcggcagg cgaccagcag tccgcattgt tcggccaggc atgctttgaa 904681 gaaggcatgg ggaaaaacac ttacggcaca ggatgtttca tgctgatgaa taccggggaa 904741 aaagcaatta agtccgaaca tgggcttttg acaacaatcg cttggggcat tgacggaaaa 904801 gtgaactatg cgttagaagg gagcattttt gtcgcaggct ctgccatcca gtggcttaga 904861 gacggtttga gaatgttcca ggattcatcg ctaagcgaat cttatgcaga aaaagtggat 904921 tcaactgacg gcgtgtatgt tgttccagca tttgtcggac tgggaacgcc ttactgggac 904981 agcgatgtgc gcggttcggt tttcggcctg acaagaggga caacaaaaga gcactttatc 905041 cgtgcgacac tggagtcatt ggcttatcag accaaagatg tgcttgacgc aatggaagca 905101 gattcaaaca tttcattaaa gacgctccgt gtagacggag gagctgtaaa aaacaatttc 905161 ctaatgcagt tccaaggaga cctgttgaat gttcctgtgg agcgcccgga aattaatgaa 905221 acgactgcac ttggcgcggc ttatttggcg ggtatcgctg tgggattctg gaaggaccgt 905281 tctgaaatcg cgaaccagtg gaatctggat aaacggtttg agcctgaatt ggaagaagaa 905341 aaacgaaatg agctgtataa aggctggcaa aaagccgtga aagcagctat ggcttttaaa 905401 taaagtaata ctatggtata atggttacaa gttaataaga acggtcctga gatgaggaga 905461 gaccacagca ccaaagtgta agcatgcact ttggctgttg tggtctcttt ttctatttac 905521 cgtgacaaca aggaggaaac gtaatgatga atcatcaatt ttcaagtctt gaaagagatc 905581 gcatgctgac agacatgacg aaaaaaacat atgacctatt tattatcgga ggaggaatta 905641 caggagccgg aacagctctt gacgcggcat caaggggaat gaaggtcgca ctaagcgaaa 905701 tgcaggactt tgcggcggga acatcaagcc gatcaacgaa gctggtacat ggcggcttgc 905761 gctatttaaa acaatttgaa gtgaaaatgg tcgctgaggt aggaaaagag cgggcgattg 905821 tgtatgaaaa cggcccgcat gtcactacac cggaatggat gctgcttccg tttcataaag 905881 gcggcacatt cggttcattt acaacatcta ttgggttaag ggtttatgac ttccttgcag 905941 gtgtgaaaaa gtcagaacga agaagcatgc tttcagcaaa agaaacgctg caaaaagagc 906001 ctttggtgaa aaaagacggc ttaaaaggcg gcgggtacta tgtggaatac cgcactgacg 906061 atgcgagact gaccatcgaa gtcatgaagg aagcggttaa attcggggca gagcctgtga 906121 attactccaa agtgaaggag cttctttacg aaaaaggcaa agccgtcggc gtattaattg 906181 aagatgtgct gacaaagaaa gaatataaag tgtatgcgaa aaaaattgtc aatgctacag 906241 gcccttgggt cgatcagctc agagaaaaag accattcgaa aaacggaaag catttgcagc 906301 atacaaaagg cattcacctt gtatttgacc agtctgtctt tccgctgaaa caggctgtat 906361 atttcgatac acctgatggc cggatggtat ttgcgattcc tcgtgaaggc aaaacatacg 906421 tgggaacaac agacactgtt tacaaagagg cgctggagca tccgcggatg acaacggagg 906481 atcgtgatta tgtcatcaaa tcaatcaatt acatgttccc ggaactgaat atcactgcga 906541 atgacatcga atccagctgg gcggggctgc gtccgctgat tcatgaagaa ggcaaagatc 906601 cttctgaaat ttcacggaaa gacgagattt ggacatctga ctcaggcctg atcaccattg 906661 ccggcggaaa actgactgga tacagaaaaa tggcggagca catcgttgat cttgtccgtg 906721 atcgcttaaa agaagagggc gaaaaggatt ttggaccatg taaaacgaaa aacatgccaa 906781 tctctggcgg gcacgtcggc ggttcgaaaa atcttatgtc cttcgttacc gcgaaaacaa 906841 aagaaggaat tgcagccggt ttatcagaaa aagacgcaaa acagcttgcg atcagatacg 906901 gctctaacgt agatcgcgtc tttgaccggg tagaagcgct gaaagatgag gccgcgaaac 906961 gcaacattcc ggttcatatt cttgctgagg cagaatacag tatagaagaa gagatgactg 907021 caacccctgc tgacttcttt gtccgcagaa cgggacgttt attttttgat atcaattggg 907081 taagaacata taaagatgcc gttattgatt ttatgagcga gcgattccaa tgggatgagc 907141 aggcgaaaaa caaacataca gaaaacctca acaagctttt acacgatgcg gtcgtaccgc 907201 ttgagcaata aatcataacg ggctgtctgc agcccgttat ttctttttac gtgccgaaag 907261 ggggagatct caggttatca agtgacagag gcacccgctt catataaaat aatggcataa 907321 gctgatacat aggaggacga atatgacttg gagaaagagc tatgaacgct ggaaacagac 907381 agaacattta gatctggaat taaaagagcg ccttattgaa ttagagggag atgaacaggc 907441 ccttgaggac tgtttctata aagaccttga attcggtacc ggcggaatgc gcggggaaat 907501 cggcgccggg acaaatcgga tgaatattta cactgtgcgc aaagcatcgg ccgggtttgc 907561 ggcatacatc tcgaagcaag gtgaggaagc gaaaaaacgg ggcgttgtca ttgcttatga 907621 ttcccgccat aagtctccgg agttcgcgat ggaagcggca aaaacacttg cgacacaagg 907681 catccaaaca tacgtgtttg atgagcttcg cccgacgcca gagctgtcat tcgctgttag 907741 acagctgaac gcttatggtg gaattgtggt aacggcaagc cataacccgc ctgaatataa 907801 cggctacaaa gtatacgggg atgatggcgg ccagctgcct ccaaaggaag cggacatcgt 907861 cattgagcag gtaaacgcga ttgaaaatga gctgacgatc acagtggacg aagaaaataa 907921 gttaaaagaa aaaggcttaa tcaaaatcat cggtgaagat attgataaag tttatacaga 907981 aaaactgacg tccatttctg tacatcctga attatcggaa gaagtagatg taaaggttgt 908041 tttcacaccg ctgcatggaa ctgcaaataa accggtcaga cgcggtcttg aagcactcgg 908101 ctacaaaaat gtaacggttg tcaaagaaca ggaactgccg gattcaaact tctccactgt 908161 tacatcgccg aacccggaag agcatgcggc attcgaatat gccattaagc ttggggagga 908221 gcagaatgca gatattctca tcgcgacaga tcctgatgct gaccgcctcg gcatcgcggt 908281 gaaaaacgat caaggcaaat atacagtgct gacaggaaac caaaccggag cgttgctgct 908341 tcattacctg ctttctgaaa agaaaaaaca aggcatcctg cctgataacg gtgttgttct 908401 caaaacgatc gtcacaagcg aaatcggccg tgctgtagct tcttcattcg gccttgatac 908461 gattgatacg ctgacaggct ttaagtttat cggtgaaaag attaaggaat acgaagcatc 908521 aggccagtat accttccaat tcggttatga agagagctac ggttatttaa tcggggattt 908581 tgcccgcgat aaggacgcca ttcaggctgc gcttttggca gttgaagttt gcgcgttcta 908641 taaaaaacag ggaatgtcat tgtatgaggc gctcatcaat ctctttaacg aatatggttt 908701 ttatcgtgaa gggctgaaat ccctgacgct gaaaggcaaa caaggagcag agcaaattga 908761 agcgattctt gcttccttca gacaaaatcc gccgcagaaa atggcgggca aacaggttgt 908821 cacagcagaa gattacgctg taagcaaacg gacgcttctg actgaaagca aagaagaagc 908881 catcgacttg ccaaaatcaa atgtattgaa atacttcctg gaagacgggt cttggttctg 908941 tctccgtcct tctggaactg agccgaaggt taaattttat ttcgccgtaa aagggtcatc 909001 tttggaagac agtgaaaagc gacttgccgt cctttctgaa gatgtaatga agacggtgga 909061 tgaaattgtt gagtcaacag caaaataatt caagtatgag ctgggtcatt gtaaatgatc 909121 cggctttttc tttttctcat ccaaaagtct gaaagaaaat catcctacaa gtgaagcaat 909181 gaaatacaaa aaactggtat aatcttaaat acaagatcaa tgccggagtg agaaacgtga 909241 gcaaaacgag gatggaaaaa ttaaaaacgc tgaaaacgat tgcggaaacc ttaaatcaag 909301 ggcacgatat caaagcaaca ctggatgagg ttttaaaaga gttgctgagt ctgacaaacc 909361 ttcaatccgg atggattttt ctgatcgaag aagatgggtc ttatacgtta gcggccgacg 909421 cttatctgcc cccggcttta agccgcaagg aaaaagtgct gatgtgcgaa ggggagtgtt 909481 actgcctgac gaaattcaat aacggagggc ttagaaaagc tgcaaatatc atgaactgca 909541 aacgcatcga atcagcagaa aacctgcatt gttttgacac agaagggatt acgcatcatg 909601 caactgtgcc tttagaagac ggggacagaa gattcggatt gttaaatgta gcggcggccg 909661 gaaaaaccat gtttgatgag gaagagctgc atttactcga gtctgtcgcc tttcagatcg 909721 gaacggcaat ccagcgtatg aggctttctg aatatcaaca aaaaaatgct cttttaatgg 909781 agcgtaaccg cctcgctcag gagcttcacg attcagtcaa tcaaatgctg ttttccgtca 909841 gtttaactgc caaagctgcg aagacactaa caaaagatga aaatttacag cagatgattg 909901 atttcatcca aaacctatca caggacgcgc tcgcagaaat gaaagcgtta atttggcagc 909961 ttcgccccgg aggattggaa aaagggctgg ctgaagccat taaaagctat ggtgcgctca 910021 ttggattgaa gatcattttt acacaaaaag gctgtcctgt tctgactgat gagcaggagc 910081 atatgctatg gcgtgtcgta caggaagctt taaataactg caaaaagcat gccggaacgg 910141 atacggcgta tgttagtctg actgcttctt tgtgccatgc ggagctggat atcatcgatc 910201 atggggcagg atttcgctat gaagcgcatg ccggtctgcc ttcacttggc ataaaaggta 910261 tgaaagagcg agcggaaaaa gccggagcta agttttggat tgagtcagcg cttggaactg 910321 gaacaaagct gtccatcagg cttccgctaa aaagccgaaa aggaggggcg gtatgaaaat 910381 tgtcattgct gatgatcatc atgttgtcag aaagggtctg cgttttttct ttgccaccca 910441 ggatgatatt gaagtcgtcg gagaagctgc aactggatta gaagccctcc gtgtcatcga 910501 agagacaaag ccggatcttg tgctaatgga tttgtctatg cccgagatgg acggcattca 910561 agccattaaa aaagcaatac agcaatttcc ggatacgaat atcattgtgc tgacgagcta 910621 ctctgatcag gagcacgtca tccccgcgct tcaggcaggc gcgaaggcgt atcaattaaa 910681 ggatacggag cccgaggaat tggtgaaaac acgacaagtg catggtggcg aatacaagct 910741 ttctacagct attatgcccc atgtgctgac acatatgaaa aatcagcacg acccggaaaa 910801 agaaaaatac tatcaattaa ctagaaggga aaaagacgtt ctgactgaaa tagcgaacgg 910861 gaaaagcaat aaagaaatcg cagcagcctt gtttatttca gaaaaaacag taaaaaccca 910921 tgtatcgaat cttttagcaa aacttgaagt ggccgatcgc acgcaagcag cgcttttcgc 910981 agtgaaatat aacctgaatg gagagatctc aaaatgaaca tgttagtcat aaatggcacg 911041 ccaagaaaac atggcagaac aagaattgca gcatcctata ttgcagctct gtatcacacg 911101 gatttgattg atctaagcga gtttgtattg cccgttttta acggtgaagc ggaacaatct 911161 gaactgttga aagtacagga gcttaagcaa cgcgttacga aagcggatgc gattgtatta 911221 ttatcgcctg aatatcacag cggcatgagc ggcgctttaa aaaatgcctt ggattttcta 911281 agcagcgaac aattcaaata taagcccgtt gcattattgg cagtagcggg aggcggaaaa 911341 ggcggcatca atgcgctgaa caatatgaga actgtgatgc ggggtgtcta cgccaatgtc 911401 attccgaagc agctggtgct tgatccggtg catattgatg ttgaaaatgc tacagtggct 911461 gaaaacatta aggaaagcat aaaagagctt gtcgaagaac tcagcatgtt cgcaaaagca 911521 ggaaatcccg gcgtctaaac gccgggattt gtttatgtga gaagggctat ttgatcttca 911581 taagtcagct ctgtggcatg atcaatatat cggagaaggg aatacagcat cttttctaaa 911641 acggcgtaat cctgttcaaa atgatacgca tgcagaaaat gctcaattcg ttttgataac 911701 aaatcgtcct ctgtacgcac cattaaaatt aataaattat cccattgaga acgatgggtg 911761 taataaagcg ctttatcgta atcggcataa tccatgaatc gcttctcctt tcttgggtga 911821 gaagttcatg attagtttat gccgcatcct ctgttattga cggggcaaaa cttgccgtct 911881 gcgtcagtaa aggggtagca atatgaggga gacataaaat caaaatgcct gaatgaagat 911941 atcgcttttg gtaaacctat gagggaatat attctgggta caggagactg aaaaaatgaa 912001 atccctgccg tataccatcg cacttctttt ttgcggattg attatcgtgt caatggctgc 912061 aaaaggtcat tcaacggaca cagacgagtc cgttcaaaag tgggaacagc ttgcctggag 912121 caaaattcag gatgaatata agggcgcttc attttctgat tatgcttata tggggcgtac 912181 agaggtgaat gatcagcaga ctaaagatgt ctttcgggtg acagtcagac agaaagatga 912241 cactttttct gttcgggccg aagtctattt tcatccggtg acaaatcata tgatcagcat 912301 caacgtcttt aggctctaat aaaaaactgt acagccgtta aggccgcaca gtttctgttt 912361 ttagaaatat cgttttgcac cgagatagcg ctgtttccag taagagttgt tcatattgga 912421 aatgacaact ccggaatcgt tggcatttat gaattccccg ttgcctaggt aaattccgac 912481 gtgggaaggg ccggctttat atgttgaaaa gaaaacgaaa tctccgacag caggctggct 912541 aactgatttc attgtgttcc aatatcccgc tgccgttaat ctagatacgg atgtgacttt 912601 gttcagtaca tagtaaatga atccgctgca gtcaaacccg gacggtgtcg tgcctcccca 912661 gcgatacgga accccaagct gcgctttagc ggccgaaatc attgtgttaa tcttcgcact 912721 cgttgagctg gtggtgtttg aagaaccgga tgaagacgat gatgaagctt ttccggaaat 912781 gaccagcttt tggccaacct gcaagacatc cgtttttaaa ttgtttttct cacgaatctg 912841 ctgagctgtt acattaaatt tttgagcaat cacccataag gaatcaccgc ttttcaccgt 912901 gtatgtagtc gtcgtgccgg agcttgcatt tgacgaagaa gacgacgatg atgaagagcc 912961 tgaagatgct ttacctgtca gcttcaatac ttgtccaacg taaagcacat ctgatttcag 913021 attgttgata tttcggattt gctgtacagt caggttatag ttgtttgcga ttttccaaag 913081 tgaatcaccg cttttaacgg tatatttagt tgttgctgaa gtttggttcg atttggatga 913141 attgtcttta gaagacgtat cagagccgct tgattttgtt ttcaacacct gattcacgta 913201 aatggtgtct gattttaagt tgttcaagac cttcaattca gcgatggaca tattgacttt 913261 gtttgcaatt ttccaaagtg aatctccaag ctgcacctta tatgttcccg tagaagatga 913321 agaacttgaa ctcttattag aactgctttt tgaactggag cttgaactct tattagagtt 913381 gcttttttta ctggaactag agcttgaaga aacagtaccg gacaccttta atttctgccc 913441 agcacgaatt aaatcgctgc ttagtccgtt taattttttc agttcctgca ccgtcatttt 913501 aaactcattt gcgatcagcc aaagtgaatc tccgcttttc actgtgtaaa cagaacttcc 913561 gctcttcttg gttgttgagc ttgaagtaga tgaagaagtg ctggatttgc tgcctggaat 913621 agtaagcgtc tggccgatcg acagaacagt agtcgaaaga tgattggcgg atgtgagggc 913681 cgccacactt gtgttatagg tttgggccag tttccataaa gaatctccgc ttttgacctt 913741 aatcgttgct gcttcagctg gtgtcactac taaagttgtg ccgacaatcg cagatgctgt 913801 cagccctgct gctaatttct ttttcatctt agctctcctt tttcccccaa tgattttgca 913861 tttgctgttt cttttttata tcggcacatt tgtctcatcg ttttgccttt ttataaaaat 913921 agccaaatta tcttaacaat aagggggaaa aagggcataa aaaaagaagg aatcttaatc 913981 tattccttca tttttaaaag cttcatgata tcttctttgt ttttgacgag gtcgcgcagt 914041 gtgtatttgt ctaaaactgc gaggtaggct aaaagcgctt cattcagcac atgttttaag 914101 ccgcaaaccg gggaaataac acagagattc ttgttcgcat caaaacattc aacaatatta 914161 aaatcgtcct ccgtttttct gacaacctca ccgatgttga tgtcttcagg gtccatgcct 914221 aatcgtatgc cgccgccccg tccgcgtatc gtttctacgt agccgagctg gccgagcctg 914281 tatatgactt tcatgagatg attttttgaa atagaatacg tttcggcaat ctgttttata 914341 tttgaaagtt ctccgggacg ctctgcagcc agaaaaatca acactcttaa tgaataatct 914401 gtataattgg ttaacttcat aataagacct cagaataaga cattttctat atcttatcat 914461 aatcgattga aaaatgaaaa aaaaggaatt aaaaaacatg cacccagctg ggtgcatgtt 914521 ttttgcttac atgtcattcg gcggattttg gtttttacgg tttttttcga tttctgtgtt 914581 ttgcattttg cgttcaaatg tagacagata acgtgatgca aaatccttac cgccaaggcc 914641 gaaggataaa ccaaaagcaa gtgcgaagcc gctaagaacg atgatgaacg cggaattgac 914701 gattgtcgca gcgacaccca gctgatccag ggccataaag aaagcaagtg cgataatcgt 914761 atatttagca ataggcgcta aagacttgaa ttcctgacct tttatcatgc ttgcgagcac 914821 ttttctcacc aattctcctg cgtaaaggcc gagtccgaga atgaatactg cgacaaggac 914881 attcggcaga tacgcgatga tgccggtggc aatttctacg aggaagtgca gccgaacaat 914941 ttgaagcgcc tcagctgtaa agagcagaat gacaatgatt tgcgcaatca taccgacaac 915001 ttgagacaag gacagctttg caggcgttcc ggcttccatg cccattttcc ctaagacaga 915061 atcaaagcct gcgcgatgga gcagtccgga caccatggat ttcacccatt ttcctgccca 915121 gatacccgct aatacaagca cgatggcaat catgatgttc ggaagcatgt ttaaaatcgt 915181 attcagcata gagacagctg gttttgaaat gccggcgaca tccagctgat caagcgctga 915241 aatgaccacc ggaatcataa tgagcacata agcgattgtt ccgatgactg ctgaaaggct 915301 tgtgtctttt aagtaaattg ataaacccat acgtgccgcg aatctttcgg tgccgatgct 915361 tgcaaggaaa ttcgtaatga tatcacggac aaggcgggca acaagccatc cgattaatac 915421 gataagcgcc gctgcaaata atttcggcag aaaagcgagc acgctttcca tcatatttgt 915481 aaaaggacct gaaatgccgc tgattttcaa agaagataag acccctggca gaaaaacaag 915541 cagcacgaga taaaagacaa tttgtgaagc ggtattgaca gcctggtgaa tatcttttcc 915601 ttcagacacc aaattccact tgcgcagttt gtcactcgtg ttcagcttca tcccgatttt 915661 tttgacaagg aagctcaaaa cagaagctgc agcccatcct aacagcagaa tgagtccggc 915721 tttcagcacg cttgggatcg cagctgcaat cgccgaaagc atactgacaa acggcgatgc 915781 cactgttgtc aggtgcaaaa tgttaaagaa taaaataaag acgatgatca gtgcgataaa 915841 ataaacgacc ttgcttatga ctttttccga ggaatagcgt gaaggctttt tcccagcaaa 915901 gagcttgtcg tcgatttttg ttttgctgag tcctttgtat accgcttttt caatgatttt 915961 agcaatagcc cagccgatta ataagacgag taaagcaatg attacgtttg gcagcttact 916021 gagataagaa gaaaacacgt ctgctacatt caattggtat cgctcctttt tcgtagtatg 916081 gtgtgtgttt acccacttat ccaataagca aacagatgaa tgtgccgggg gaattttttc 916141 ttgcccgagt gagactatca tcttttgtct ggcgggctca tacattatag ataagtccaa 916201 gtagggggga ttcggttgaa cgcggaggag aagaagggat tacagcgggc aattgaggaa 916261 attaccgaaa ttgcaaaagg attcggcctt gatttctacc cgatgagata tgaaatctgc 916321 ccggctgaaa ttatttatac atttggcgcg tacgggatgc cgacaagatt cagccactgg 916381 agcttcggca agcagtttca caagatgaag ctgcactatg atctagggtt aagtaagatc 916441 tatgagctgg tcattaactc agatccatgc tacgcttttt tgctggacag caactcactg 916501 atccaaaata aattgattgt cgcacacgtt cttgctcatt gcgatttctt caaaaacaac 916561 tgccgtttcc aaaacacgaa gcgcgatatg gtggaaagca tggcggcaac agctgaacgg 916621 ataaaacact atgaacaggt tcacgggata aaagaagtcg aatctttttt agatgcaatc 916681 ctttcgattc aggagcatat cgatccgtcg ttggtccgac caaagctcca atggagtgtg 916741 gatgatgagg aagaggagat tgaagaggca gccacgcctt acgatgatct atggtcttta 916801 gatgaaaaga aaccgaaaaa acaagtgaaa aaatcgaaaa aaccgttccc gccgcggcct 916861 gaaaaagata tcctgctttt tatcgaggag cattcccggg agctggagcc atggcagcgt 916921 gatatattaa cgatgatgag agaggaaatg ctttatttct ggcctcagct ggaaaccaag 916981 attatgaatg agggctgggc ttcctattgg caccagagaa ttatacgtga gcttgattta 917041 acctctgatg aagcgatcga gttcgccaag ctgaatgcag gtgtcgttca gccgtccaaa 917101 acaggcatta atccttatta tttagggctg aaaatatttg aagacattga aaagaggtac 917161 aacaacccga cggaggaaat gaagaaaatg ggcgtgcagc ctgactccgg ccgggagaaa 917221 atgtttgagg tcagggagat tgaatccgat atctctttca tccgcaatta tttaaccaaa 917281 gaattagtca tgcgcgagga tctttatttg tttcaaaaac agggccgaga ttataaaatc 917341 atcgataaac agtggaagtc ggtgcgcgac cagctcgtaa gcatgcgggt aaatggcggt 917401 tttccatatt tgacagtaaa cgacggcgat tatatgaaaa ataacgaact ctatattaag 917461 cattggtatg agggcataga gttggatttg aaatatttgg agaaagtgct tccttattta 917521 ttccagcttt ggggaagaag cgtgcacatt gagtctgtgc ttgaggataa ggaagtcatg 917581 ttttcgtacg acggaaaagg tgttcaccgc agatatttat aaaaaagagg atgcagcgtt 917641 ctgcatcctt tttattttcc agtttttaaa atcttaaata tgatgtttgc ctggtccgta 917701 ttgttaatca atccgcggaa tttttctttt ccggggccgt acgcgtatac cggtacttct 917761 tcgccggtat gatcggtact cgtccatccg ctgttggagc gggtattaaa aatcttgatg 917821 atggctttgg aggccccttt gcttttgtca gcctgtgcag ctgcttcaac gcttttgatt 917881 tcttcagatg tgactttcag attggcatag cgggcgagca catctttaac cggcttgcct 917941 tcactgattt ttttggccat gaattcaggt gttttcttag cggagagaat cggttctgcg 918001 tgccaattct tttccccgtt tgcgccaatg gtaaagccgc cggttgtatg gtcagcagtt 918061 gcaatcacaa gtgtatgttt gtcttttttc gcaaattcaa tcgcggcttt ataggcctgt 918121 tcaaaatctt taacctcgct catggctcct actgtatcat tgtcatgggc cgcccagtca 918181 atctggctcc cttcgaccat caagaaaaat ccttttttat tttggttcag gcgatcaatt 918241 gctgaaaccg tcatgtcttt gagagacggt gttttactgt cacggtcgag cgctttagca 918301 agccctccat ctgcgaaaag cccgagcacc tgctgatctt tatttttttt caatgcttgt 918361 ttagttgtca catagctgta gccggcttgt ttgaattcct ttgtcaagtt tctgtccttg 918421 cggttaaaat aagattttcc gccgccgagc agcacgtcta ttttatgttt gccttttatc 918481 ttgtcatcca tatagctgtt ggcgatttgg tccatgtttt tccgtgattc attgtgggcg 918541 ccatatgcgg ctggagtggc gtggttaatt tcagacgtgg cgacaagccc tgttgacttg 918601 ccttgctgtt tggcctcttc aagtacagat ttcacttttt ttccgttttt atcgacgcca 918661 attgcattgt tatatgtctt aacgcctgtc gctaatgctg ttccggctgc tgctgaatct 918721 gtaatattat agtcagggtc atccggatgc gtcatcatca tgcctgtcag gttccggtca 918781 aattctgtta acttcgggtt attcggtgtg tcaccgttat ttttcatgga acggtaggct 918841 cttatgtaag gcgtccccat gccgtcgcct atcatcacaa tgacatttct gatctcagct 918901 ttgtcttgtt ttttggcgct ggccttttct gtttgctgaa gctcagctcc ggcaaagatt 918961 ccagctgtaa ggacagaaac agcggcgatt ggcagaagtt ttgatttcat attttgaaac 919021 aaactcattt ttttcatgcc tcctttaatg tattccgttt atcatgttag ggaaactttg 919081 ttaaatgcgg ctgttgatca tgtaaacaat aagtaaagcc ttgtaaggaa atgaaaaaac 919141 gcttttcgtt atcttgcctt atttgatgta aagcattcat ttttcagaaa aatctttacc 919201 tctctgtctt tgcatgatat gtttgtttaa ataaaaaaac tgcggataac cacagctctc 919261 ctcgaatata ctttatcact catttttccg atatatgagc cgaccccgaa agtttttcat 919321 ttatttcctt tatgttgaaa aacatcccat aaaacatgac aaaagcactc gttttttgtc 919381 acctttgcaa tgaaaatgaa atatttaata cccttaaaaa ctttttttta gaacgaataa 919441 ttaagaaatt tgtcacatga agtcaagact atttctgatg ggaatctatc cttataatag 919501 aaatcaataa gattaattta aaaaaagaga tacatatata tagagttaac atttggggag 919561 gaaaatatga aaaagcaaat cattacagct acgacagcag ttgttttagg atcgacgtta 919621 tttgcaggag cggcatctgc acaaagcatt aaggtgaaaa aaggcgacac gttatgggat 919681 ctttcaagaa aatacgacac aacgatcagt aaaattaaat cagagaacca ccttcgttca 919741 gacattattt atgtgggaca aactttatcg attaacggca aatctacaag ttcaaaaagc 919801 agcagttctt cttcctcttc ttctacatac aaagtaaaga gcggggacag cctttggaaa 919861 atttcaaaaa aatacggcat gacaatcaat gaactgaaga agctgaatgg cttaaaatca 919921 gatttgcttc gtgttggaca agtcctgaaa ctgaaaggtt caactagttc aagcagctcc 919981 agctcatcaa aagtgtcatc gtcttcaact tctacttata aagtgaagag cggagacagc 920041 ctttctaaaa ttgcgagcaa atacggcact acggttagca aattaaaaag cttaaacggc 920101 ttaaaatcag atgtaatcta tgtcaaccaa gtattgaagg tgaaaggaac aagcacaagc 920161 agctcaaaac ctgcttcatc ttcatcgtct tcaagcagca aaacgtcatc tacatcactt 920221 aatgtgagca agctggtttc tgatgcaaaa gcgttagtcg gaacgccata taaatggggc 920281 ggaacgacaa cttcaggctt tgactgcagc ggattcattt ggtacgtact gaataaacaa 920341 acaagtgtgg gcagaacaag cactgcagga tactggagtt ctatgaagag cattgccagc 920401 ccgtctgttg gtgatttcgt cttcttcaca acatataaat ccggcccttc tcacatgggg 920461 atttacattg gaaacaacag tttcattcat gcaggatctg acggcgtaca aatcagcagc 920521 ctgaacaaca gctactggaa gcctcgttac ctcggtgcga aaagattcta atttttagag 920581 aaaacccgtt cattggaacg ggtttttttc attagacgga gcacaggcgt tttggttgct 920641 cctaaaaatg aaaatgtgat aaaaaatcca agaacttttt ttctttctta ttttcataaa 920701 gggcaatcgc gtaagcgccg gcatagggca gctgtacaga ctgataagga attctgatca 920761 tctgtttctc tgctaactca cgctttactg tagataaagg cagaaatgaa actccgagtc 920821 cttccttgat aaaccgtttc gttatatgtg tttgagtgac cttcattgtt ctcacaaatg 920881 gaaatgtcat tctgacttga cggagcaagt cgtcccagta atcaggatga ttgtgggtca 920941 aaagcaggta ttgttcgagc acctctttgg catcaatttc gttgtcttct atgaaacgct 921001 tatcgggcgg ggcaacaagg acgacagggt ctttgtataa gcagtggcag cttaaagaag 921061 aagactgtac ctttaaacag cttagtccga tatctgcttc cccggcttta atcagtgacg 921121 cgatttccgc tgattcgaaa atcgtaaccg ccatttctgt ttccgtattc attgctgtgt 921181 accgcttcat gacagaagga agcactgtat ctgcaataag cggagaaacc gcgagctgta 921241 aggtttgaga gtagccttgt ctcactctgt gaagctctgc catgctgttt tcataatcat 921301 caagaagcct gagcgcatac ggcaaatacg ccctgccttc atcagtcagc tggatttgcc 921361 tgcctttacg ctcgaacagc ttgcagctga tttctttttc taattgcttg atatgtacgg 921421 tcacagtagg ctgagataag aaaagcgttt ccgccgtttt tcggaagttc tcatattttg 921481 cagcggtcac aaaggtgtga agccatttga aatccatttc tattctccct ctgattaata 921541 tttttaatta attcccttta aaatattgat tattttttaa atattatatt tactataata 921601 acagaaaagg atagggggaa tacaaatggt acattacgga ttaaagggaa ttacatgtgt 921661 agaaacatcc atcagccata ttgatggtga aaaagggcgt ctgatttaca gaggacatca 921721 tgcaaaagac atcgcactga atcacagctt tgaagaagcg gcttatttga ttttatttgg 921781 aaaactgcct tcaactgaag aattgcaggt atttaaagat aagctggctg cggaacggaa 921841 tcttccggaa catattgagc gcttgattca atcactgcca aacaacatgg acgatatgtc 921901 ggtgctgaga acggttgttt cagcattggg ggaaaatacg tacacattcc atccgaaaac 921961 agaggaagca atccggctga ttgcaatcac gccttctatc attgcataca gaaaaagatg 922021 gacgcgcggt gaacaagcaa ttgcaccttc ttcccagtac ggacatgtcg aaaactacta 922081 ttatatgctc acaggtgaac agccttcaga ggcaaaaaag aaagcgcttg aaacctatat 922141 gattctggcc acggagcacg gcatgaacgc atcgactttt tcggcacgag tcacgttatc 922201 tacagagagt gatttagtgt cagccgtcac ggctgctctc ggtacgatga aaggtccgct 922261 gcacggaggt gctccttctg cggtgacaaa aatgcttgaa gacattggag aaaaggaaca 922321 tgctgaagca tatctgaaag aaaaactcga aaaaggagag cgcttgatgg gattcggcca 922381 cagggtgtac aaaacaaaag acccgcgggc agaagctttg agacagaaag cagaagaggt 922441 ggccggcaat gaccgtgatc ttgatcttgc gctgcatgta gaagcagaag cgattcgttt 922501 gctagaaatc tacaaaccgg gacgaaagct gtacacaaat gttgaatttt acgcagctgc 922561 agtgatgagg gccatcgatt ttgacgatga attgtttact ccgacctttt cagcaagccg 922621 aatggtaggg tggtgcgccc atgtactgga acaggcagaa aacaacatga ttttccgccc 922681 gtcagcgcaa tataccggtg ccattcccga ggaagttctt tcataacata ttttggcgtt 922741 tattcatttc tgtcgtgtgg taacgttcag tatcaaccac atgtctagga gtgatgaatg 922801 tgaacccaat ggacagacaa acagaaggac aagaaccgca gcatcaggac agacagccgg 922861 gcattgagtc aaaaatgaat ccgctgccgc tgtcagagga cgaggattat cgaggaagcg 922921 gaaaactgaa aggaaaagtt gcgatcatta ctggaggcga cagcggaata gggagagcag 922981 cagctattgc ctttgctaaa gagggggctg atatctccat tctatactta gacgagcatt 923041 cggacgcaga ggaaacacgc aaacggatcg aaaaggagaa tgtccgctgc ctgcttatcc 923101 cgggagatgt tggggacgag aaccattgtg aacaagctgt gcagcaaaca gtggaccatt 923161 ttggtaaact cgatatctta gtgaacaacg ccgctgaaca gcatccccag gacagcattc 923221 tcaatatttc aacagaacag ctggaaaaaa cctttcgcac aaatattttt tccatgtttc 923281 atatgacgaa gaaagctttg cctcacctgc aagaggggtg tgccattatt aatacgacat 923341 cgattaccgc ttatgaaggg gatacggcgt taattgatta ttccagcaca aagggtgcga 923401 ttgtttcctt tacgcgttcc atggcgaagt cgcttgcaga taaaggcatc agagtgaatg 923461 cggtggcgcc cggtccgatt tggacaccgc ttattccggc gacattccct gaggaaaaag 923521 tgaaacagca cggcttggat accccaatgg gaagaccggg acagccggtt gagcatgcag 923581 gcgcctatgt tctgctggcg tctgacgaat cttcctatat gacagggcag accattcatg 923641 tgaatggcgg ccgttttatt tcaacgtaat caacgaaaaa ccagctcaag agctggtttt 923701 ttgtgtggtg aaaaatttca aaataaaaaa tttgtcgatt tttctaacaa ttttgttttc 923761 atttttgcaa ttttatatat aatattgagt aggagaaagg aatgattcgc gaccagtaca 923821 aatatagtag aaaaaaaaga ataatgacca ttgttactca tgaattcaga aaattcaaat 923881 aaaatatata aaaatagatg atcgggagtt gaaggggaat gaaagggagc gtttttagga 923941 agaaaagcat tcaggattta atcgctgcga cgagcgggga aaagtcttta aaaagagaat 924001 taggggcatt tgatttaacg ttgcttggaa tcggcgccat tattggcaca gggatttttg 924061 ttctgacggg aacaggcgca gtcacggccg gtcccgggct gacgatttca tttgttgtgg 924121 cggcgttggc ttgtttattc gccgccctgt cttacgcgga atttgcgtca agtgtgcctg 924181 tttcaggttc ggtgtataca ttcacttatg cgacattggg agagcttatg gcctttatta 924241 tcgggtggga tttaatttta gaatacatgc tggcggtaag tgcagtgtcg gtcggctggt 924301 ctggttattt ccaatcgttt ttatcagggc ttggcattca tcttccggtt gctttaacag 924361 cggcaccggg cgcagtgaaa ggcaccttta ccctgtttaa tcttcctgca ttcgtcattg 924421 taatggcgat cacatatttg ctttatttag gcatcaaaga atcaaaaaga gtcaacaata 924481 tcatggttat cttgaagata ctggttgttc tgctgtttat cgcggtggca gccgtttacg 924541 tgaagccgca caactggcag ccgtttatgc caatgggctt tggcggcgtg ttcagtgcag 924601 cggcgctcgt attctttgct tttatcggat ttgacgctgt atcctctgct gcggaagaaa 924661 cgaaaaatcc cgcgaaggat ctgcctaaag gcattatttt ctctttactg gtctgcacga 924721 ttttatatgt caccgtatca gccatcatga ctggggttat cccgtttgct caatttgcgg 924781 gtgtggatca tccggtttct cttgttcttc aaagcgcagg gcaaaattgg gtggcaggca 924841 tcattgatat tggcgccgtg ttgggaatga caacagttat gctcgtgatg ctttacgggc 924901 agacccgcgt catgtttgcc atgtcgcgtg acggacttgt gccgggttca ctttctaaag 924961 tgcatccaaa gcacaaaaca ccttatgtag ccacttggtt tttcggaacg atgtcggcgc 925021 ttctcggctc acttgttccg ctggatgaac ttgcaaagct ggtgaacatc gggacgttgt 925081 cggcatttgt cctgatttct gtggcagtta tcgttttgag aaagaaacag cctgatcttc 925141 cgagagcttt taaatgcccg ggagttcccg tgatcccagg cctggcgatt ctgttctgcc 925201 tgttcttgat tttaaatctg ggatgggtga cgattgtccg cttcctagtg tggctgttaa 925261 tcggcttggt aatctatttc ctgtattcaa gaaagcattc aaaattaaat caataacctt 925321 ttgataaaga gagcggccat acaggccgcc tcttttctgt tcttggcaaa tgaatctata 925381 gaaatgaaga caaaaataag agataatata ggctggaaag gaagtgacgt ttattgtctg 925441 agcaaaaacc agtccaatgg gcttcgaaaa ttggtttcgt catggcagcg gccggctcgg 925501 ctatcggctt gggcgcgatt tggaagttcc cttacgtagc ggggaccaat gggggaggag 925561 ccttttttct tatcttcgtg ttatttacca tcctcttagg ctatccgctt ttggtggggg 925621 aatttatttt tggaagacgg aaccagacga atgccattga tgcatataaa aaagaagcgc 925681 cgcgatcagc ttggtttctt acggggtgga tcggcgtagc ggcgtgtttc ttagtgctgt 925741 cgttttacag tgtaatcggg ggatggattt tgctgtatat cgtgaaaaca gcgtcaggat 925801 cactgtccgg gctttctcaa gcacagtatg gcgctctttt tgcttctatt atccaaaatc 925861 cggtgcagac gctcgcggct cagcttgtct ttatggcact gactgtactc gttgtcgcaa 925921 gaggggttca aaaagggatt gaacgggtaa gcgcggtgat gatgccgatt ttgtttttat 925981 tgtttattct gctcgttctt cggtctctta cgcttaatgg tgcaatggaa ggcgtaaagt 926041 ttctgcttgt gcctcatttc ggcgatctga ctccggaatc catattattc gcgctgggac 926101 aggccttctt tacgttaaca ctgggggttt cggtgatggt gacctacagc tcctatttgc 926161 cgaaaacaca aaatatccct cgttcggcag cctccattgt cttgatgaat atcattgtga 926221 cactcttggc aggtttggct atttttccgg cggttttctc attcggtttt cagccaaatg 926281 aaggaccgac attgctgttt acagtgcttc cggccgtttt tgaacagctt ccgttcggca 926341 cattgttttt tatcggcttt ctcgttgcat ttttatttgc agccttaacc tcagcatttt 926401 cgatggttga aattatcgtt gccacaatcg gaaaagggga cgaaaagaag agaaaaaaac 926461 tgtcatggac gagcgggctt ttgatctttt tggtcggaat cccatgctgc ttgtcttatg 926521 gcgttttgag tgatgtgcac ctatttggca aaacgttttt tgatattgcc gattttaccg 926581 tcagcaatgt tttgatgcct tcaggcgctc tgttaatttc tctatttatc ccgctgaaaa 926641 tttcgaaaag cgaactcttg gctgaaatgc gaaatggatc aaatgcaggt aaagcattct 926701 tttacacatg gttttatttg cttcgtttta tcgtgccgct tgccattatt atcgtgttct 926761 taaatttaat cggaatttta tcattttaaa aaacaggctc cgtttccggg gcctgttttt 926821 tatttaataa gatgatatca acggtgccca tgccgttttc agtttttgga tgccgagcct 926881 gatgtcctct tctgacaaac cgccataacc gattaagaca gaagtaaaag gcgtctgttc 926941 tatatatgag ggagacacgg gatagagggt tacaccgtgg tcagcggctg cttgtattgc 927001 ttcttcctca cttgctggaa acaaaaggcg cagcagaatg tgaagccccg agttcttacc 927061 gagaatctca acggtgtttc ccagttcaga gcgaatggct tctaacagga cagcgtgttt 927121 ttttcggtat aagcttctca ttctatttat gtgtttttgc cactctccgg tttcgatgaa 927181 gtctgccagt gccaattgcg agtgggcaga aacggtctgc ttcattaact gaacattgtt 927241 ttggatcggt tccatgagtt cagggggcac aatcatgaag ctgagccgca aggaaggcag 927301 aagtgacttt gaaaaagtgc ccagatatat gactctgcca ttcggatcaa gaccctgtaa 927361 agacggaatg ggatggccgc tgtagcgaaa ttctccatcg taatcatctt ctataatgaa 927421 tgaatttgtt tctgccgccc atgccagcag ctcctgtctg cgggtaatcg tcataatggt 927481 cccaatcgga aactgatgcg aaggagtcgt atacatgaga taaggattct gacggtagag 927541 ctcatccggc aggacgcctt ctgcatcaga acaaatcgga gtgacatcca tgtgatttgc 927601 ttcaaacatc cttcttgaac ggtgaaagcc cggttcttca aagccgattt ttgtacctgg 927661 ctttagcgaa aggcaaagat tttgcagaag cacggtggtt cctgcgccga tgataatctg 927721 gccgggttca caatttactc cccgagacag cctgacgaat cgggcaatca tgtgcctgag 927781 ttcgtattct ccttgagggt cgccagaggt gtgaaacgat ccggaatagc gatcaagact 927841 ttttactatg ctttttctcc atgcgttaaa gggaaagagg gtcggatcaa cgctgccctg 927901 atggaagtca atagcaggtg cgtttttttg atgtaatccc ggctgtacag actgctgaaa 927961 atggtcagga gctgtcggga atcctggttc tacttccgcc gcgaaccagc cgattttcgg 928021 cttgcttttg acatagccct cagcagttaa ttgctcataa gctcgttcta tagttgccgt 928081 gctgacatcg agcaagctgg agagcctgcg ttttgacgga agtcttgttc cctttgtgat 928141 tcgcgcatgt gaaatttctt gtttaaaaaa ggtataaagc tgttcataca gcggtgtttt 928201 gctcttttta tcaagaaacg gcgtaatatc catctcatgt ctcctttgta gctggcatgg 928261 tcattttttc tgatattggc tatttggcaa atgccattta ttagctatga tcattgtaac 928321 gaaaggaaag gggattgaga agatgatcca tatgaaacaa ttaacctcga aagaagaatg 928381 ggctgagtcg tatccgatta tgagtgaatt gagaacagaa ctggatatag agacgtattt 928441 acaaaggctt gaagcctgtg tgcagaaaga atcgtatatg ctgtttgcct tatatgaaaa 928501 tacagcaatc agagcgctgt gcggggctct gccgagagtt tccattcata aaggagagca 928561 cttgtggatt gcggatcttg ttacaacggc accttgccga tcaaagggat acggcaaaat 928621 gcttttggat tatgcctcag actgggcgag aaaagccgga ctcggttttg tcagtctttc 928681 atctggcctt cagcgtaaag acgcacatcg attttataca gataaaatgg gttttactat 928741 agaaagttat ttgttccgaa aaccggtata acgaaaaaag acgcctgaaa aggcgtcttt 928801 tttaaaagcc aaactgtaaa ttcgtatcta cagatacaat ggtatacaca caaataatca 928861 caaagagatt aaggatgacg ccgagcaggc ctggacctgt gcgccctctc ttgatgaaga 928921 gttcaacaac gccgaacgga acggcagcca tggcgaacgg aagcatttga taggaataaa 928981 acgtgacgtt gctgataatg gccaaattca gcaacagcag ggacagaacc gctgtcccga 929041 cagagatcca gccgaataca ttgtgttctt taaaaattct taccagttcc ataattccac 929101 ctcgccgaca ttcgctgatt ttacagattt atttttcagc atgcgctgga tttccttggt 929161 tggccctgta acgaccgaac cgtatacatt gacaccgttt ttctctacat aatctaatcg 929221 gttatctaca ttcaggtctt tccgttttga aatgacctga gcccattttt cgtgtttgga 929281 catgaatttc agggcgttga taaactgatc gccattcgac ttgccttttg tattaagggc 929341 ggccaagaac tttgaatcct ttccaggata gccaagaggt tctgtggaag ctgtcttatt 929401 tgtgtttttc tctgtttcga ttgcgttcca caaaaagctc acatcatagc ctttgaattt 929461 gttatacacg tcttttgtcg gatatgcacg gtcatatgaa aggtagacct ctgataccgt 929521 tccttcaggc aatgtgctta acgttttttc tgcttttgcg gtcgtttgtt cagacttgtt 929581 tgaaggatgt gtaaagtaat ggccggtttt attcacttct aagtcatagt agtttactgc 929641 cggcgctttt actttgttat aaaacatttc aacccgttca ttccctacgg cagccgtctt 929701 cgtgccaatc tgcttttgca gcgggaattc cgtattcatt ccaaatagct tcacttggct 929761 tttcagtccg gaagtatcaa caagaacatt cggcatggtc agggctacag tgactgcggc 929821 agtttccata aactcattgc cggtgctgtg ttttccaccc attccgtaat agaggtagct 929881 tcccagcgta caaagcggca aaatcatcaa tgtcgaaatg acggcaagca cagaaattcg 929941 caaataagac ttgcgtttgc cgtaggctaa aatcgctttt tgtttttcag gactgatgct 930001 gagatcccaa tcgttatcgt cctctagttc gctgtcaatc agttcctgat atacttcaag 930061 cttctcgagt tcttcctcaa atgcagtcat ttcctggtcg ctcatttccc catttttata 930121 ttgatcaaaa cgctttttaa attcttcatt catcattaac acctctatta taaagtgctt 930181 tcagccgctg tctggcacga aataaaacac ttttaaaatt cgcctctgaa atattcataa 930241 tatgggatgc ttctttgtag tttaactctt ttaaataata tagcgttaag gcctcccgat 930301 aattatcggg gagctcggac atataaccag tcagcacttc ctttatctct acctgatggg 930361 caggactttg aacagcattt tgaaagaggc ttccgattaa gtcatcagaa atggttactt 930421 ctttcttatg ctttctgacg taatcaatga aggcgtttcg cgccacttga aaaagccagg 930481 gctttacttt gctgtgatca taggagtgaa tgtgtatgta tgcccgcata aaggtttcct 930541 gcagtaagtc ttcagcaaga tgcttgtctt ttgtcatgga gagcaggaac ctgtaaacat 930601 cattcatgta catttggtaa atttcatcga tcgtcactgc cttttctccc ctctatgtta 930661 tacacgcata agaaaggttt aaagttgcac attacatgca aacggctttt ttatacctaa 930721 tcaaacacca ttactatata gtacccaaaa atggccgcaa aagatagtgc ggagaaaggt 930781 ttaacatttt ttccagaggg gaaaagatag tgaaaaagtg aaggagtggc acaatggaat 930841 ataccagtat agcagataca ggaatagaag cctccagaat cggcctcggc acatgggcca 930901 ttggcggaac gatgtgggga ggcactgacg aaaaaacatc gattgaaaca atccgcgccg 930961 ctcttgatca ggggattaca ctgattgaca ccgcaccggc ttacggcttc gggcagtccg 931021 aggaaattgt cggaaaggca atcaaagagt acggcaaaag agaccaggtg attctcgcaa 931081 cgaaaacggc tctggactgg aagaacaacc agctgttccg ccatgcgaac agagcgagaa 931141 ttgtagagga agttgagaat tctttgaagc ggcttcaaac agactatatt gatctttatc 931201 aggtgcattg gcccgatccg cttgtgccaa ttgaagaaac ggctgaagtc atgaaggaat 931261 tatatgatgc gggaaaaatc cgggcgattg gcgtcagcaa tttttcaatt gagcaaatgg 931321 atacatttcg cgccgtcgca cctctccata cgattcagcc tccatataat ctgtttgaaa 931381 gagagatgga agagagtgtc cttccttatg cgaaagataa caagataaca acattattat 931441 acggcagttt atgcagaggg ctgttaacag gcaaaatgac tgaagaatat acatttgagg 931501 gcgatgatct gcgtaatcac gatccaaaat tccagaagcc ccgctttaaa gagtatcttt 931561 ctgctgtgaa tcaattggat aagctggcga agacacgtta tggaaaatca gtgattcact 931621 tggctgtcag atggatctta gatcagccgg gagcggatat cgctctttgg ggagcaagaa 931681 agcctgggca gcttgaggcc ctatctgaga ttacaggctg gacgctgaac agtgaagatc 931741 agaaagatat caatactata ttggaaaata cgatatcaga ccctgtcgga ccggagttta 931801 tggccccgcc gaccagagag gaaatataac aaaagctgag ggcgaatcct cagctttttg 931861 gcgtttaaac gagagaaatc ttaaaaatta gtaccaggta ataaaaaata ttgttataat 931921 agatgacaga aagaatcatt gattacgaca aaggaagtgc gatatgtata agttttgtgc 931981 aaatgcttta aaagttattc tttctcttcg cggaggagtg aaggtgtata acaaagaaaa 932041 ccttccggcc gattcaggtt ttgtcatcgc gtgtacacat tccggctggg ttgatgtgat 932101 tacactcgga gtcgggattc ttccttatca aatacactac atggcgaaaa aagagctttt 932161 tcaaaataaa tggatcggtt cgtttctgaa gaaaattcat gcctttccgg tagatcggga 932221 aaatcccggg ccaagcagta ttaaaacgcc gattaagctg ctgaaagaag gagagatcgt 932281 cggtatcttc ccaagcggaa caagaacctc tgaggatgtg cctttgaaaa gaggtgcggt 932341 gacgattgcg caaatgggga aagcgccgct tgtccccgct gcatatcagg gcccttcaag 932401 cggaaaagaa ttattcaaaa aaggaaaaat gaagctgatt atcggtgagc ctcttcacca 932461 ggctgatttt gcccacctgc cttcaaagga aagacttgca gcaatgacag aggctttgaa 932521 tcagcggatt aaagaactag agaataaact tgatcagcta taaggcgttc tgagagattg 932581 tcctgaaact gtgaaaataa gaaaagcacc ctatacaagg tgcttttctt attatgcttc 932641 ctgctggtta gctgtctcca gaagttcttc ttcttgaagc tttttcactt caatatatgc 932701 gacgtggtgg ccgtcaattt cattaatgat gaattcgcag ccctcttcga tgatggaatc 932761 atctttttca acatcgtatt tttgagtaag gaaccagccg ccgattgtat cgacttcttc 932821 gttctctaaa tggatgccta gcaggtcgtt tacttggtca attaacactt ttccgtcaag 932881 aatataatgg ccttcgccga ttttgcggat ttcgctaatt tcatcaatat caaattcgtc 932941 gcggatttca ccgacaattt cctcaatgat gtcctcaacc gtcacaagcc cggcagtacc 933001 gccgtattca tcagacaaaa tggccatgtg gaccctctct ttttgcattt tgacaagcag 933061 gtcttggatc ggcgcagatt caatgacatg aatgataggg ttgacgaatt gagaaatggt 933121 ggaatcaaca gatacctcac cgctgatgca ggcggtcagc acttctttaa tgttaataac 933181 cccgataatg ttatctttat cgccctcttc cacagggtag cgggtatatt tttcaatctg 933241 aatgatgtcc atcatttcag aaatcttgat atcatgcgga aggctgacaa tttcggtccg 933301 cggaatcata atttctttcg cgagcctgtc gtcaaattca aagattttat tcacatattt 933361 aaactctgat tggttgattt caccgctttt atagctttca gacaaaatga ttcgcagctc 933421 ttcttctgag tgagccagtt cgttttctga aacggtctcc aggccaaatg ctttggtcaa 933481 taaccgtgcg gaattgttca aaagccaaat gaatgggaac gcgatgcggt aaaaccaaat 933541 cagcggtttc gcaaacagca tagacactgc ttccgccttt tggatagcga ctgttttagg 933601 tgcaagttct ccgacaacaa cgtgtaagaa cgtgataatg gcatacgcaa aaataaacga 933661 tatgacatgt gaaagggaac ctggaacgtt catttggacg aaaagcgggt gaagcagcct 933721 ttcgatcgtt gattcaccta aaacccctaa tccgatggaa gtcaatgtaa ttccgagctg 933781 acacgcagat aaatattcat caagatgcgt ggtcactttt tttacggcta ttgctgcttt 933841 atttccttcc gcgatcagct gatcgatccg tgagcctctg attctgataa tggcaaactc 933901 agatgccacg aaaaatgccg tcagggcgat taaaacagca actaaaatca aattcactat 933961 gtccaattag aaccttcact ctagcaatga gaatgaaggt aacacctcct gttagataaa 934021 atggttttaa cttaacagca gcataaatga ttggaacacg gcgagctttt caggcgggag 934081 tttgcttttc agcttgtcac gatcctcggg cttcagccgt tcaaaccgat gcaagattcc 934141 ggagatgttt tgattcatat gatcaatttc taatgccaga tttccaattt catcatcaag 934201 tttagctgaa gagggaaact ggttctccag tcgatcttta atatcggaca gggccaatcg 934261 ctgcttcttg caatctacaa taaatataag tcgtttgagt gcattttcgt cgtagtaacg 934321 gtaatttgaa caggatctgg ccggcgtaag cagaccgaga ttcgtataat aatcaactgt 934381 ccgtttcgtt actccggcga gtgccgctag ttcactgatg cgataagtct cagccccatc 934441 tatatccctc ccaaccatca cgttatagtt atgagaatag tttaatatat gaacggtgtc 934501 ttgcacaagt ttattgtttt ttttagaccg gaattggaag ttgtggaatt catcatctga 934561 ttgaagtaac ataggaagat agaattttca aatttttata tgcggaaggg acagatgaaa 934621 ttggctgggt tatcccggga agttgaagaa aacttaaata aaggatcatg gattcgcaag 934681 ctgtttgatg aaggtgcaag gctgaagaag gagttcgggg aagaccaggt atttgatttt 934741 tcactcggca acccgattgt tgaaccgcct gaagctttta agagagcgtt aatagaggaa 934801 gctgaaaaag gcagccacgg atacatacaa aaccaagggc ttcttgcagc gagagaaaaa 934861 gtcgcgcaat ttctgggctc gcgttttgaa gctgatttct cagcggagcg catcgtcatg 934921 acggtgggcg cgggaggcgc tttgaatgtt gcgttaaaaa gcatcgtaaa ccctggggaa 934981 gaggtcatta ttcttgcacc ttattttgcc gaatataagt tgtatattga gaactacggg 935041 ggaaaagccg tcagctgccc gttgacaagc cggtttgaga tcgacattga agcggtaagg 935101 caatcgatca ctccacagac gaaagggctg attctcaata caccgcataa ccccacaggc 935161 actgttctca gccagaaaaa tatagacgat ttaggcgctt tattaaaaga aatagaagag 935221 aagagcggcc agacgattta tgtgctgttt gatgaaccgt acagtcaatt aatctatgat 935281 gaagagctgg caaatccgtt tcaatcgtac catcgtgtga tattggccag ctcattcagt 935341 aaagatctcg gcatagccgg agagcggctc gggtatatcg gattggacag ccgaatgccg 935401 gatgcggacc ttttgatcaa cgcttttgtg tattgtaatc gaacgcttgg atttgtgaat 935461 gcccctgtca tgatgcagcg ggctgtggca cgaatggatg atttaagagt agacgcgagc 935521 gcttataaag agcgccggga tttaatggta gacattttaa aagaagccgg ttttgaattt 935581 gaaatgccaa agggaggttt ctttgttttt ccgaaatcgc cgattgaaga tgaagttgca 935641 ttttgcgtgc atgccgccca aaaatacaaa ttattaattg tgccgagcag cggttttgga 935701 atgagcgggc atttccgatt atccttcagt gtgccgatcg agcagattaa aaactcacgg 935761 gacattttca tttctttata taaagatttt gcttaagaag gcaaagaaaa gaaaacagtt 935821 ttcaaggctg ttttcttttt atatccgcaa aatccttcct cttccaatcc agacaggcgc 935881 agaattgaca agcaggcatg cagttaaggc tttcttcatg ataaaagtct aaaaattaaa 935941 aatcattttt ggaatgagtt gtgttacaat aaaatataca atttataatc aaactttgac 936001 ttttggaggt ggtatgatgg ggccctctgc ttaggcaaca atacaccgcg tacctcaatg 936061 ttaaggaaaa atgattatat caggaggtga ctccttatcc tttgttgaga ggatagggtt 936121 aaatggacga tattgacagt ctgattttaa ttggcgtgct cattgcttta accgcgtttt 936181 tcgttgcaag cgagtttgcg attgttagag tgaggagatc cagaatagat cagcttatca 936241 cagaaggaaa caaacgggcg atactcgcaa ggcgtgtcat tacagatttg gatgaatatt 936301 tatccgcatc ccagctaggc attacattga catcaatcgg gcttggcgta ctgggtgagc 936361 cggcctttga acggctgctg catccactgt ttgaaccgct cggcttgccg gactcggttt 936421 cacatgcagt ctcttttgca gtcgcgtacg gcttgatcac gttcctgcac gttgttgtag 936481 gtgaactggc cccgaaaacg gtcgcgattc aaaaggcaga acagctgact ttactgatag 936541 cgggcccttt gcgtttattc tatttgctcc tgtttccgtt tatttggatc ctcaatggat 936601 cggcgcggct tttatgcggg atgttcggtt tgaagcctgc gtcagaacat gatggttccc 936661 attctgagga agaactcagg atgctgttat ctgagagttt aaaaaacgga gagattaatc 936721 cgtctgaata taaatatgtg aataagattt ttgaatttga taatcggatc gccaaagaaa 936781 ttatgatacc gcggaaggaa atggctgctg tgtcaactga gatgacgatg gccgagatgc 936841 ttgaagtcat gctgaaggaa aaatacacgc gctggccagt cacagatgga gacaaagaca 936901 gtgtgctcgg tttggtcaat acgaagcatt tgttttctga tttgctgttt atgacagaag 936961 aagaacgaat gaagatgacg atccatccgt atgtgaggcc ggtcatcgaa gtgattgaaa 937021 cgatcccggt tcatgacttg ctgattaaaa tgcagcgcga gcgcattcat atggctatat 937081 tgtcggatga atacggagga acctcgggac ttgtgacgac agaggatatt cttgaggaaa 937141 ttgtcggaga gatccgagat gaatttgatg aagatgaaca gccgctgatc caaaagcttg 937201 gcgacggcca ttatgtgatg gatggaaagg ttcggatcga tcaggtgaac agccttcttg 937261 gcgcatcgat tcaagaagac gtcgatacga tcggcgggct gatattaaaa gaaaacatcg 937321 atattgaggc tggtgaatcc attcgcatcg gttcatatac gataaaggtg ctgaagatgg 937381 acggccgatt aatcaagcaa atcgatataa aagaagaagc cggcaacaca accgggatta 937441 cggcgcacca caagctgccg ctgcccgagc ctgtgatgct gaacagtgca accttgagcg 937501 agaaataagc tcaaggtttt tttatattgt gattgtccag ccgcaccaaa atgcaaaaag 937561 cgacccgcaa agtgtcagga cgatgtacaa gatgctttct tttacacgtt tggccataag 937621 gagttgaata gtttcaacgc tgaatgtgga aaaggtcgta aaggcgccaa aaaaccccgt 937681 gccaatgata agcgagaccg aagcatttgc aacgtgaagt cctgtaaata ttccgagccc 937741 gagagctccg agaatattga ctgtcagtat gccaatgggc aggctgagac ctttggtttt 937801 ggcggttatg acattgccaa gccagaagcg aagcattgcg ccaagtccgc cccctatgaa 937861 aatacccgct agtgtcattt ttcctgcagc ccctttcttt gctgaatgcc tgctatgcgc 937921 cgtcccacaa aaacaccaat cagtgcaaat atgatccctg atatcaatga ggctgccaca 937981 tataaaagag ccaatgaggg ttgtccttgc aaaagcatca ctgtttcctt agaaaacgtg 938041 gacattgttg tgaagcctcc gcaaaagccg gtgcctaaaa aagccgacag cagaggccgt 938101 tttgccccga tcataaaaaa tccggtcaaa atgcctaata gaaggctgcc tgccgcattt 938161 tccagccagg ttgccgccgg gaactgaccg gtgtgtatcc ataagtttaa tccgtatcgg 938221 aggcaggcgc caagcgcgcc tccgataaaa accgcgctat atattttcat gtttgccatc 938281 ctttatgatg aaatccgggt aatctgtaac gatgccgtcc acgcccatgg cttgtaattt 938341 tgccgctgtc ttttgattgt tgacagtcca tgcaaatatg tttaagccat ttttattgat 938401 ggagccgatc atcagacggt taagccgtgt gtgttttata ttgacatagt ttgcaaaaga 938461 gcggaaggcc ttcatctgat ttctggacag catgccaaag ttgggccttg taatgaccgc 938521 tgtcggaatc gaaggataaa gctcgcggaa cctttggacg gagcggaact gaaaggattg 938581 aacaatatta ttgatagaaa aagaaaattg ccctaatagc tgtcccacct cttcttcaat 938641 tccgacttga gacggatggc cttttagttc aattaaaagg ccgatttttt tgtggtagcg 938701 cttgagcacc gcttccaggg ttggaatacg ctctccttga aaagcgggac cgtaccagct 938761 tcctgcatcg agtttttgca attcctccaa ggtaaaatcc ttaacaaagc ccgatccgtt 938821 tgttgttcgg tcaaccctgt catcgtgtat cacaacaatc tgcctgtctt ttgtaagctg 938881 gacatccagt tcgatcatat ctgcattcat tttcaccgca aggtcaaatg cggcaatcgt 938941 attttccgga gcgtagccgg atgctccgcg atgggcaatg atgtacaagc taagtcagct 939001 cctcgtatgg gcatttctgt tattgtatca aatccatata tgcaccgcga tacaaactgg 939061 tgaatttttt ctgccatatc ggaatggtcc gggctgagga atgcgtataa ctaaaaaaag 939121 acactcagcg tatcagaaca catttcgtca gaaaattagg tctttcgaca tgttcacaac 939181 aaaatatgat cctttataat agcaaaaaag gaggcgagat catgggaaaa gggagaatca 939241 gagtggagga aagaattaaa gccgaaacgg atgctgaaat gcaaaaagca actctccttg 939301 atcagacaca aacgaaaaaa ggtaagtgac tgtccctatt gaatctggct gatagatgaa 939361 ttgagaaatg accccggcgt ttcgccgggg ttttgtgctg cataagacat ttaaatgaac 939421 atccttacga atattttagt ataataaaca attgattggg atagagggga gacagtcatg 939481 ccggattatc tgcagcagta ttttacgctt gataacatca tacaaatcgg catcagcttg 939541 gcgattttgc tggtgtttct tatacttaga aaattattca caagatattt ttttaacctg 939601 ctttttaatt tgacaaaccg gccgaaaaca gaaattttta aacaggtggt tctggcgttt 939661 gataagccgg ccagatggtt ttttgttgcc cttgggctgt ttttagcgat ccggtattca 939721 ccgtttttag atgagcaaat gccggtcatc agcaaaatat accgctcact gattgtggcg 939781 ctcttgtgtt ggggtctttg taatttgacc gcaacatcgt cgtttatctt ccataaggtg 939841 aaccagcgct tcgagcttga catggatgac attctggccc cgtttttatc caaattgctc 939901 cgttttgtga tcattgcgct cagtgtcagt gtgatcgctc aggaattcaa ttatgatgtc 939961 aacggatttg tagcgggcct tggtcttggc ggactggctt ttgcgcttgc cgcgaaggat 940021 accatcagca acttcttcgg cggtattatc attattactg aaaagccgtt tacaattggt 940081 gactgggtgg agacgtcgac agtaacagga tcagtcgagg atattacctt taggagcacg 940141 agattcagaa cagcacaggg ggcgcttgta acggtgccga actctacgct gtcgatggaa 940201 gcgatcacga actggacaag aatgaccaaa cgccagatta cgttttccat ccatgtgtcc 940261 tacgctacgc cgattgagaa ccttgaacgc tccattcatt ctctcagaac aatgctctta 940321 gagcatgagg gcgttgataa tgaaataatc atggtcaact ttgatacgtt tgccgacagc 940381 tactacaatt tattttttaa cttctataca aaaacgacgg tttgggctga aaaccttaat 940441 attagagagg atatcaacta taaaattatt gagattttag gtgcagaagg cgttcagttt 940501 gcatatcccg gccaaatggt tgttgtcaag caaaagcacg aaagcgacca attccaggtg 940561 aatctaaata aagaggaaaa ggaacgggct taaaagagag acttcgtctg acagaggcgg 940621 agtctttttc atggtaaaat aagagaaaaa ggcggtgttg agttggaaac attcaaaagt 940681 attctacatg aagcacagag aattgttgtg ctgaccggag cgggaatgag cacagaatca 940741 gggatccccg actttcgttc agcagggggc atttggacgg aggatgcctc aagaatggaa 940801 gcgatgagcc ttgattattt tttaagttat ccgcgtctgt tttggcccaa attcaaagaa 940861 ttgttccaga tgaaaatgag cggcagcttt gaaccgaatg aaggccattt gcttttagct 940921 gagctggaga agcaagggaa gcaggtcgat attttcacgc aaaacattga cggtcttcat 940981 aaaaaagcgg ggagcaggca tgtgtacgaa ctgcatggtt ctatccagac agcagcttgt 941041 ccggcatgcg gcgcccgata tgatcttccc catttgctgg agcgggaggt gccggagtgc 941101 acggcggccg gaaacaatgg ggacatttgc ggaacggtat taaaaaccga tgttgttctc 941161 tttggcgatg ccgtcatgca ctttgacacc ctttatgaaa agctggatca agcagatctt 941221 ttattggtta tcggcacgtc tctcgaagtg gctccggcta gatttgtgcc tgaggatgca 941281 agcctgattc ccggcatgaa gaaagtcatc ataaaccttg aaccaacgta ttgcgacagc 941341 ttgtttgaca tggtcatcca tcaaaaaatc ggcgagtttg cccgaagttt gggcatgaaa 941401 aagtgagccg ctttatgcgc ctcacttttt tattcatgaa caggaaccat tgtgtcctct 941461 aacactccga aggaatagcc tttttctttt aatttattga ttagtaccgg cagcgcattt 941521 acagtagcag gaagatcatg catgagaatt acatttgggc ggcttgaaga gctgtgttcc 941581 atattctcaa gctgctgtaa tacggcggtc acatactgtg aattccggta tttccagtcc 941641 atgctgtcga tcgtccaatc ccagtacaca aacccatctt tctccagatt gcgaatttgt 941701 gaggcggtta gtgacggctt gcttccgtat ggcgttctga caagatcggt tttatatcct 941761 gtaatgtcct gcagcgtgtc acgcgcctcc tgcatttctt ttagcggaga tgtcggtgtt 941821 tgatagaaca atctgttatt gtgggtaacg ccatgtaaac cgagtgcgtg gccttccttt 941881 tctgctcttt tcacagcctg cttgaattcg ttcatccgcg gtgacagcat aaaaaacgtc 941941 gcttttacat cagcgctttt cagtacgtcg agcaagcggg ttgtaacggc tgaagggccg 942001 tcgtcgaagg ttaagtaaac cgttttatct cccatgttct gctttgtctg cagatgtttt 942061 atcaggagat cgggggagtc gtttttcagc ttaaggcttt ccttctcatc tcgaagctgg 942121 ccgtttgttg tgacagtgac ttcctttgct ttcgttgaac tgttggaata acccaaaatc 942181 accataagca aaagcagcac acataaaact gctaaacttg caaatttaaa agcaagcgaa 942241 actgcagaag gagaagcctc tcctctcgtt tgtcgcataa caatctctcc attggcataa 942301 aatctctaca taatgctgta cagcaggcag cttatgaaga tgccttatgt ttacaaccta 942361 tgtattacca gtcaagtata caggaataaa actggaaagc acatagaaaa tttgtcgaaa 942421 tgtcagattt taaggaaaaa ataaactcct ttccgctata gatctcttga tctttctgtt 942481 tttcagcttg tccaatatgg tagaattagt gataatgaca gcttgaatga catcagggac 942541 atctcgaaaa gggagggctt ttatgaaggt tttagtcaat ggccggctga ttgggcgcag 942601 tgaagcatca atcgatttgg aagatcgcgg ttatcagttt ggtgacggca tctatgaagt 942661 gatcagggtg tacaaaggag tattgttcgg cttacgtgag catgcagagc gttttttcag 942721 aagtgctgct gaaatcggaa tttcactgcc attcagtata gaagatctcg agtgggacct 942781 gcaaaagctt gtacaggaaa atgcggtcag tgagggagcg gtatacattc agacaacaag 942841 aggtgtggcc ccgcgaaaac accagtatga agccggcctc gagccgcaga ctactgccta 942901 tacgtttacg gtgaaaaaac cggagcaaga gcaggcatac ggagtggcgg ccattacaga 942961 tgaggatctt cgctggttaa gatgtgatat caaaagtctg aatttactgt ataatgtcat 943021 gacgaagcaa agggcctatg aagccggagc atttgaagcc attttactta gggacggcgt 943081 tgttacggag ggtacatcct ctaacgttta tgccgttatc aacggcacag tgcgaacaca 943141 tccggctaat cggctcattc tcaatggaat tacacggatg aatattttag gactgattga 943201 gaagaatggg atcaaactgg atgagactcc tgtcagtgaa gaagagttga aacaggcgga 943261 agagatcttt atttcgtcaa cgacggcaga aattattccg gtcgtgacgc tcgatggaca 943321 atcgatcgga agcgggaaac ccggaccggt gaccaaacag cttcaggctg cttttcaaga 943381 aagcattcaa caggctgcta gcatttcata aatgaacgaa gaaaagagcc cgctttttac 943441 agcggggctc tttttatttt ttaacaaatc caatcaaaat ggagatcatt ggcgatatat 943501 agaggaagaa cgtaaatggg atgtagtcta tgactggaac accaagtgcg ctcgccataa 943561 atgcgccgct gacgccccaa ggaatcaatg ggttaattaa tgttccgccg tcctctaatg 943621 atcttgtcag aaattttcgc tggatgtttc gtttgtcata taaagattta aatgattgtc 943681 ccggtattaa tatcgataaa tactgttcgc ccgttgccaa gttgacgccg atgcttgagc 943741 agacagttgc tgcaacaaga cggccttttg agcggatgcc tttcatgacg ccttccaata 943801 gtgcagaaat caatccgatt ttctccatca atccgccgag tgcaaaagca atcataatga 943861 gagagacaga gcccatcatg gattgcagtc cgcctctgtt aataatttta gcggctgcct 943921 cattgtcagt ttcgaaagtt gtgccatttt gtaaagctgt cataaacgcc tgcaggctgc 943981 tgtagggtac aaaaatagca gtcaaaattc ccgaggaaat aattccggca gtcagaacgg 944041 ggattactga tacccgtttc attgccagca aaacgactaa gagcggagaa agaagggccc 944101 acggtgtcac gtttgcagca tcttttattc cggttatgac ctgctgaata ttatcggttg 944161 aagcagcgtc cgctgacact gatgaaccga gaaagtaaaa cagaacgaca gtgatgagca 944221 aagctggaat ggttgtgccc atcatatggc gaatgtgttc aaagattggt atttcgccta 944281 ttccggctgc aaagttggtt gtgtccgaca tcggcgacat tttatcccca aaacaagcgc 944341 cgcatatgac tgcgcctgct gtccattcaa gcggaacgcc agccgcgctc gccacgccga 944401 tcagcgctac tccgattgtg cttacagttg tcagacttga gccaacaagt gtgctgatga 944461 tcatacatga aaacaaagca gtcaacagaa ggtggcttgg ttcaataaag gatagggcat 944521 aaactgtcat agtcggtatt gcgccgctgt acatccaggc gccgattaag atgccgatca 944581 gcgctagaac aataatcggc tgtacgccgt ttttgatccc gtctacaatc cctttttcaa 944641 tgctcttcca gggaaatcca aaccataaag ctgctgctga aagcatgaca acacttaaaa 944701 acagcgggat atgaggttct acatgaagca agaataagca agaaataata atgcacaaca 944761 tgaatataaa taaaccgacg gctaacggaa acgtcagctt tttttgagaa tccaaaataa 944821 caccccatat ttatctttaa tgcttttgtg cttttgggca cgaaagcatt ataacagaaa 944881 aaaacgaaaa tctatgtttt ttcacaatta tgaatataaa agaagtgagc acagggcgtg 944941 ctcactttac aatcaggacg ggtatatccg atttcgctga aagcttttca cttacacttc 945001 cgaatattag ctttttcagc ctgttttggt ctctgcttcc ggttacgatc atatcggcag 945061 aaatgcggtt tgcatgctcg ataattgatt cagccggatc gccttctaat atatcgatat 945121 ctccatctgc ctgctgttca ttcagcatca ttctggcttc ggcgatgact tcttccgtac 945181 ggtcttcata gatcattggc tcaggtgatg ttacatccga tatcagcgga tcaggaacac 945241 ttgtcatgcc tccgctgata tagcttgcct cagctgcggg tctgggcggg tcgatgacgg 945301 tctgattgtc tttcatatca tgtgaatggg cgacggtaat agcggcattt acggttttag 945361 caagatcaat ggctgtcaga agcgctttct tactattttc acttccgtca aacgcaacaa 945421 tgatacggtc agcatggaac atccttctca ccctttcaaa gcgtcttaca acactactac 945481 ccgaatttga gcacaattaa ccttttccta ttcaagtaat gattgacaat aaaaggtttt 945541 gtttatatga tgataaaaag atgaaatcag aatggaagga gggtttgcta tgccaaggaa 945601 tttgcgtgtt tatcaaacag tttcatattg gcgcggcaaa ccttttgttc tgttttcgtg 945661 aacggttttt taggtcggac cgcgcgctga aaagcgctgt gcgtaacata tcggttaaaa 945721 aaggcatgga gctgacgctt catgcctttt ttatatacaa aatctaagga aagacaggtg 945781 tatgggatgt gaagacaaat acagaggcga gggcagttcg tgccaaactg gatgaaaaaa 945841 gctgcaagga aaaaatagaa ggcggctgat gaggagatgg ggatagatgt tttcagtttt 945901 gaaaaagctt ggctggtttt ttaaggcgta ctggctgcgc tatacgattg cgattgtcct 945961 tttattagca gtcaatgtca ttgaaatgtt tccgcctaag ctcttgggga acgccataga 946021 tgatatgaaa gcaggggcat ttactgcgga agggctgctg ttttatatcg gtatcttttt 946081 tgtgctgacg gcggccgtgt atatcatgtc ttatttttgg atgcatcagc tgtttggcgg 946141 agcgaatctg atggagaaaa ttcttcgtac gaagctgatg gggcatttgc tgactatgtc 946201 gccgccgttt tatgaaaaaa accgaacagg cgatttaatg gcacgaggga caaatgatct 946261 tcaggccgtc agtttaacca cagggtttgg catcttgacg ttagttgatt ctacgatgtt 946321 tatgatgacg atctttttga caatggggtt tttgatcagc tggaagctga cctttgccgc 946381 cattatcccg cttccagtca tggcgattgc aatcagtcta tatggaagta aaattcatga 946441 gcggtttact gaggcccaaa acgcgttcgg ggcgctgaat gacagagtgc tggaatctgt 946501 ttcaggcgtg cgggtgattc gcgcgtatgt tcaggaaaca aacgatgttc gccggtttaa 946561 tgaaatgacc gctgatgttt atcagaaaaa tatgaaagtg gcttttattg attcactgtt 946621 tgagccgacg gtaaaactgc ttgtcggcgc aagctatctg attgggctcg gctacggagc 946681 gtttcttgta ttccggaacg agctgacgct tggagagtta gtgtccttta acgtttatct 946741 cggcatgatg atttggccga tgtttgcaat cggtgaactc attaatgtga tgcagcgcgg 946801 caatgcgtca ttagatcggg taaatgaaac tctttcttat gaaacggatg tgacagatcc 946861 aaaacagccc gctgatctta aagagcctgg agatatcgtt ttcagtcatg tcagctttac 946921 atatccaagc tcaacaagtg acaatcttca ggatatttca tttacggtgc gaaaagggca 946981 gactgtcggg attgcaggta aaaccgggag cggaaaaacg acaattatta agcagctttt 947041 gcgccagtat cctccaggtg aagggagcat tacattttca ggtgtaccga ttcagcaaat 947101 ccctcttgac cgtctccgcg gatggatcgg atatgtgcct caggatcatt tactgttttc 947161 acggactgta aaagaaaata ttttatacgg aaaacaggat gcaactgata aagaggttca 947221 gcaagccatt gccgaagcac attttgaaaa agatttgcac atgcttccgt ccggtctgga 947281 gacaatggtc ggtgaaaaag gcgtggcact gtcaggcggg cagaaacaaa gaatttcgat 947341 cgcgagagca ctcatggcga atccggaaat cttgattctg gatgattcac tttccgctgt 947401 agatgccaaa acagaggctg caattatcaa gaacatcaga gaaaaccgca aaggaaaaac 947461 gacatttatt ttgacacacc gattatccgc ggtagagcac gctgacctga tccttgtgat 947521 ggacggcggc gtcattgctg agagaggcac gcatcaagaa ctgctggcca ataatgggtg 947581 gtaccgggaa caatatgaaa gacagcagct gttcactgcg gaagaagggg gagcaggggc 947641 atgaaaatag gaaaaacgtt atggagatac gcacttcttt atcgaaaatt gctgatcaca 947701 gccgtccttt tgctaactgt tgccgtcggt gcagaactga ctgggccctt tattggcaaa 947761 aaaatgatag acgaccatat cctcggcatt gagaaaacat ggtatgaagc tgcggaaaaa 947821 gataaaaatg ccgttcagtt tcacggcgtc tcatatgtca gagaggaccg attgcaggag 947881 cctgtttcaa aagcaaaaga agcgcatatt tatcaagtgg gaatggcgtt ctattttgtt 947941 gatcaggctg tcagcttcga cgggaataga acggtttctg acgggaagct gacgatcaca 948001 aacggagaca agagccgggc atatgctgcc gaaaagctga ctaagcagga acttttccag 948061 ttctatcagc cggaaataaa gggaatggtg ttactgatct gcctgtatgg gggcttgctt 948121 gtgttttcgg tattctttca atacggacag cattatctgc tgcagatgag cgccaatcgg 948181 attattcaaa agatgaggca ggacgtgttt tcgcacatac agaaaatgcc gattcgctat 948241 tttgacaacc ttccggccgg aaaagtcgtt gcgcggatta ccaatgatac ggaggctatt 948301 agggatttat atgtcacagt gctttcaaca tttgtgacaa gcggaatcta tatgttcggg 948361 atattcacgg ctttgtttct gcttgatgtg aagcttgcgt ttgtatgtct ggcaattgtg 948421 ccgattatct ggctgtggtc ggtcatatac cggagatatg cgtcatatta caaccaaaaa 948481 atccgctcga tcaacagtga cattaacgca aaaatgaatg agtcaattca aggcatgacc 948541 attattcagg ctttccgcca tcaaaaggaa acaatgagag aatttgagga attaaatgaa 948601 tcacattttt atttccaaaa caggatgctg aatttaaact ccttaatgtc ccataatctg 948661 gtcaatgtca tccgcaatct tgcgttcgtc tgtctgatct ggcattttgg cggtgcgagc 948721 ctgaatgcgg cggggattgt ttctatcggt gtgctgtacg cgtttgtcga ttatttgaac 948781 cggttatttc agccgatcac aggcatcgtc aatcagtttt caaagctgga gcttgcaagg 948841 gtctccgccg ggcgtgtttt tgaactgctt gaagaaaaga atacggaaga agcgggtgaa 948901 ccggcgaagg agcgcgcgct ggggcgggtt gaatttcgtg atgtgtcatt tgcgtatcaa 948961 gaaggtgaag aggtattaaa gcatatttcc tttactgcgc aaaaaggcga aaccgtagcg 949021 ctcgtcggcc ataccggatc aggaaaaagc tcgattttga atcttctgtt tcgtttttat 949081 gatgcgcaaa aaggtgatgt cttaattgat ggaaaaagca tttacaacat gtcaagacag 949141 gaactcagat cccatatggg tattgtgctt caggacccgt acttattctc gggcacaatc 949201 ggatctaacg taagtctgga tgacgaaaga atgactgaag aagaaataaa aaatgcactg 949261 cggcaagtcg gtgctgagcc tcttcttaag aagcttccga agggcattaa tgagcccgtg 949321 attgaaaaag gcagcacgct atcctctgga gagcggcagt taatttcttt cgctagagct 949381 ttggcgtttg atcccgcgat cttgatttta gatgaggcaa cggcgcatat tgatacagag 949441 acagaggccg tgatccagaa ggcgcttgat gtcgtcaaac aaggacgcac caccttcgtc 949501 atcgctcacc ggctttcaac aatcagaaat gctgatcaga ttttggttct tgataaagga 949561 gaaattgttg agagagggaa ccacgaggaa ctgatggcat tagaaggcca atattatcaa 949621 atgtatgaac tgcaaaaggg acagaaacat tccattgcat aacgctcaaa aacccaaaac 949681 aatcgtgttt tgggtttttg gtttatgtag tcaataagcc agtccgacac ggtttccgac 949741 atactcacct gtaacgagct cacgatataa aaagtccgca gtatcgccga ccgaaatgct 949801 tgtgccgccc tcaggcaaaa cgttacgctc cgtacgataa acgccggttg ctgttccgtc 949861 cgggaggtaa gtggggcaga tgattgtcca gtctaatgat gattctttaa gcatttcgta 949921 tacttttgca tgctccttgg ctgcgcgggt ctgctttcgt ttcgattcat ttgtttcaaa 949981 ccggtatttt cccggttcat atcgggaatc taggatccct gcggtgccga tcgtaataag 950041 ccgtttgata tgctgttcct ccataacgga gagaatgtgt gccatagcag ttgacaaggt 950101 atcatcacca tctgtgccta gacagctgat cacgatttca gcattctcca ttattttttt 950161 cacatcttct aagcggcggg cgttccccat gacagttctg tcttttgaaa ggggaagatc 950221 agcatgttga gatctgatca gagcgaaaat atcaaatctt tcatctgctg cagcttgtgt 950281 taaaaaggct tgtccgacgc ggccgctggc tcctaataaa gcgattttca ttaaaaaacc 950341 tcctcgcctt tcattataaa aggatgttct cagtttgaac agcgcgggaa agaatacctg 950401 tacaaataaa cagaacgatg ggaaacatat tcatgaatca tggatacact tacgaattga 950461 accagctccc aattcacaat ggtgatgaat gacaccccga ttccctccct ttttttctag 950521 gatatgtgga gcaggaaaaa agggtgacaa aataaagaga gcgcggaaac cgcgccctct 950581 atagccatat attgaattgt tattgaactc tgccgcccat ttgctgctga gcgaaagata 950641 ctaaacgttt tgtgatttct cctccgacag aaccgttagc gcgagaagtt gtgtccgctc 950701 caaggttaac gccgaattca gaagcgattt caagtttcat ttgatcgata gcctgagctg 950761 cgccaggaac tagtaagtca tttgaagagt tttggttagc catgtgtaaa atctcctttt 950821 tatttagtat ggttgggtta actggagttg caccaatctg tgaacccttc tcgggtgtca 950881 ctgccgcctc ggcgtaaccc aatgctttgc cggcttgtta ctacgtatta tgttaaaatg 950941 gccggaaaat catgcggaga attgtgtggt aaatcttgag aaataaaaaa agcttagccg 951001 tttaggctaa gctagtcata aatatgaaaa agcatcagtt catgtatctc gtttgtaaga 951061 gcaggctcgt cagcgcgggc gggaaacaag tctccccatt caatctcacc gctcttatga 951121 tagatgcctt cataatgggt ccctttataa taaaatgaaa ttttccatcc gggcagcttt 951181 tcttttggga acaaaggttt ccagctgaaa tgagaaatca ttacggccac gctccttaca 951241 tttggtatca attgacctaa ataaaaacgg cttatgttca ttgtatcatt gtttcagaac 951301 atcattgaag aggcctaaat atgcagtttg tcccagcttt ggataaagat aagcccgctt 951361 tattaaaaaa gcggacaggt tacgaaggcc acaatgcttc cggagatgtg attgccttct 951421 cagataaata tgacgcgtat tcaaaacttc ttcgttttgt aagagaatca acatgatgca 951481 aatttggatg agaaaaaatg cttcggcccg ggcgcgaatt cgcttcaaac atccatactt 951541 taccgttctg atcaatgcca aaatcgaaac caatctcccc gataaatccc tcgatatgat 951601 catgaaggac atggcttgca gtcagtgccg ctgcagaaag ctttttaatg acctcaactc 951661 tttcagcggg atcatcgtat acttccgcaa gtgtctttac agtgccgccg ttagaaagat 951721 gtgttgtaat gctgttcttt ccggaaattt ttacggcgat tgctgtcact gtccattttc 951781 cttttctgtt tttattggta tggacacgga aatccgctgg tttgccttga aattcgatga 951841 gatcaacacc ttgctgaatg agaaagtcgg acgggttgtg atgtttttga aattctgcaa 951901 ggaatgaggc ggcatcggaa taatcaattg atgtaaaagt tttggcgtca ttcgtatgct 951961 ttaccgtcag gccgccatct gttcttgtca gctgataaat gccggtgccg agtgctccat 952021 ttgccggttt gatatagact tttttgtatg cgccacagag ctcatctatc agctccacag 952081 acggtgtcag ctcggatcta ggcaaaaagg gtgccgttct tggatctttt tcgagcaatt 952141 gatgaacgtt ccatttattg aaaaacgttt tattaaacca tgggatctga tattcatcga 952201 tcagcctctt ttttgtatgt tgcaagagaa gtgaatcttc aatttttcgg ttcggcaaac 952261 ggtcataaac gacgttcggc aatggaacga tttttttctc ccagccgttt tccctgtaaa 952321 ggaggccttc aatcgtgcct tcctcccaat tgatttggtg cgcgccaaaa acgaagcagt 952381 agcccccggc ttgctcgtgt aacgtgacaa gtttagaaaa aaagagggaa cgatccttaa 952441 atgggcgttc aagagataca gtaaaccctg ccgtaaagat gccgactaac ggcccgatat 952501 gcactgtatg atcatgaatc agtatatctg ccctgcttcg gtggggaagc aaaagctcat 952561 gaaacagatt ttcagagaga agcacggttt gttccagatg ccgtctgtaa gcaacgtggc 952621 atctgacaac cttcgttccg aatgcggcat gcaaaagtcc gtcttgcttc agcgaagagg 952681 gcagaaacag ggtgttttca ctggttttgt ctatgccgat caaaaaccgt ttaggattca 952741 cgcggaagaa ctcctttctg gctttgctca gaaaacagat attggcagcg ttttagggga 952801 caagtgtaca gctgttcttt ttgctcggga gagacacgca ggattgactt cctgcctggt 952861 ttggaattga tatctaaaat ccaaattctc ccgtcctttg caagacatat atcaagaccg 952921 agttcaaaca acggcccata gcgctcgtca agataatacg gaaccgattg ggtaattgaa 952981 aacacatcat ctagtaaaac cacttgctgt tttttcggta tatcttcaaa ccaggagtca 953041 aatgtcagcg catcagatcc gcctgacaaa ttggccagca gcccgtgttt gtatccgcgt 953101 cttactgcct ttccgactgt attccattca cctgcttcgt ttttttccat aaacagacga 953161 atatcacaag ggtattgttc cttatcttga atgtttaagt aaggctgaag caaatattga 953221 tgctgaagca cttttttgca ccatgtttta aaagaagtct ggttggaaaa cgtttttgtc 953281 tgcttatcct ttccgatgtg ataagtagca gtgatgtttt tcttgcccag cttcaaaaga 953341 atcacgcctc tgcctcccgc gccgaatgcc ggtttaagga tgcaggcttt ttctttggat 953401 aaaaaggagt gaatttgttc gtagcggctc acctttatcg tttcgggaat atagggattg 953461 attacagagt gctgctgcaa atcgtgaagg acggtccact tatcgggaag accccgcccg 953521 ataaattccg ttttcggata ttttttgagc cactcaacga ttggttttgc tttttgggaa 953581 tgtgaatcct tgccgtaaaa acagcgatca taaatataat ctggaatcgc catttcagtt 953641 tcgttccatg tgctgctggc cgaatgatag accgatgctt tgacacgcaa agtgtcaggt 953701 gaaatatcaa atggtgtaaa ccggatgaaa cgtatgccga attcgggtgc tcttttggcc 953761 agttctgcgg aataatccgc ttcatgctgg cgggataagg acataaaacc gagtgttatc 953821 atggtgagac tccccctttt attcaaaagc tgccggcggg tgtccgcagc tttacactaa 953881 atacatgtaa gacgaacgca gctgacggta ttctacttta cagaatacga ttctccacct 953941 tgccctattc caaaagaaca agctgatttt ctaagaacag gaatttgtct cctcgtttgc 954001 taagtgattg catgagcctc tataatacgt ataggtacat aatctatatg aaaaaagctg 954061 aagcacagat ggaggaagat gaataggaat gggtattgca ggaaccttta tttttatgat 954121 cgtgatcggc gctgccattg gagcggtgac caatcattta gcaattcaaa tgctgtttag 954181 gccgtataaa gcgtactatt tgtttgggaa acgagttcct tttacgcccg ggctgattcc 954241 aagacggcga gatgaacttg caaaacaaat gggactgatg gtagtcaatc atctcttaac 954301 ccctgaaggc attaaaaagc ggctcgtctc tgatgcagcc aaaacgcagg ctcttcgagt 954361 gggggaacag ctgattcaaa agctgtcact ttctgaagtg acagtaaaag aagcgcttga 954421 aaaagccggg atgaagcgcc ccgaaaaagc tgctgatgca tggatcagca gctggaccga 954481 tgataagctg catgagcttt tccgccaata cggggaccaa tcgttaaaag agctggtgcc 954541 tatagaggtg caggaaaagc ttgaggaaaa aattccgatg atttcaggat atatattgtc 954601 acggagtgtc cgttattttg aaagtgatga aggaaaaatc cgtcttggca atatgattga 954661 tgacttttta aaagagcgcg gcatgcttgg aagcatggtg caattgtttc ttggcaattc 954721 aagccttgcg gatcgcgtgc tgccggagct gctgaaattc ttgcgcaatg aggaaacaaa 954781 taaattgctt tctgatctct taaaaaacga atggggcaag ctgagggagt atacgtttaa 954841 tgaagcagat gaaaaatgga atgcaaaggc gctcattttc agtttgaaac gaagagtgct 954901 gcaagcattt tcgactgccc ctttcttcaa caatacgatt ggcacgctta ccgtccgcta 954961 tgaatctgag ctgacccagc aaatgctgcc ggcactatta gacaaattgc ttgaaggtat 955021 ttcgtccaac cttgaaagtg tcttaaaacg gttgcgtctt gaggaaatcg tcaaggagca 955081 ggtggatcag ttcccggtgg agcgtcttga agaaatggtg ctgtccattt caaaaaaaga 955141 atttaaaatg attacctatt tggggggcct tctcggcgga attataggcg cgattcaagc 955201 attgtttgtc atcctttttt aagaagaaat ggtttttgat taatgaaagg agctccatag 955261 tctgttatag tggagtggta tgtcaaacgg caatgatgaa aggagctatt tacaatggct 955321 gttaattttt atgatgtagc gtatgatctg gaaaatgcat tacgcgggag cgaagaattc 955381 acccgtttaa aaaaccttta cgacgaagtt aacgcagatg aatcagcgaa gcgcatgttc 955441 gaaaacttcc gtgatgtaca gcttagactc cagcaaaaac aaatggcagg agaagagatt 955501 acacaagaag aagtgacgca ggctcaaaaa acagttgcgc ttgtacagca gcacgaaaaa 955561 atttctcagc tgatggaagc ggagcagcgc atgagcatgc tgattggtga attgaacaaa 955621 atcattatga agcctttaga agagctttac ggcagtgttg aaggctaata agcaaaatcc 955681 cttcttggat aagaagggat tttttattca ctcagcaaac ttggaaatcc aatgaatctt 955741 ttacctctcc attgatgatg actgataatg tatgaattcc tttgtaatgc tttctggtgg 955801 ttaaatcctt aaaggattgg attcttgtgt atgacttcgt ttcgtttttt cgtatatttg 955861 tttctgttat tttaaatact ttctgatgac gctggcctct tgcttttaca aaatcaattg 955921 cgtactcaat tcttactttt tgatccctgt ctgaatgaat atagaaagaa aattcaaggc 955981 tttcgccaat aactatacgt ttgggctggc atgttaaatc atgtagttgt atcgaatcag 956041 cattttcata accaaaaagc gctaaggcct gtttatcacc cttttttaat aaggtccgat 956101 aggcgtgttt gataatccag tctgtatggg gatgtgttcc gtaccattga tctgcgactt 956161 ttctcagtaa atgaggatgc gtttttgata tatcattaag gttgttggcc acgctttttc 956221 ttacatataa agactcgtcc tgcatcagct tctcaaggat cggcaatacg ggggaagggt 956281 ccgatttcaa agccggtatc gattttcccc atggcaggcg gggcctgctg ccttcgctcg 956341 caagtcttct cacgtgttca tttttatgct cagaccatgc aagcaattgt gcaatcatct 956401 tttcttgatc taacagcaaa aaaggcctta cagcaaattc tgaggtcgaa tattgcgtaa 956461 aggattccaa tgcctttatt gattcttccc aatgcgctaa cccgtactgt tccacataat 956521 ctggaaataa aattccgctg agtcctttaa aatgaggggc tgtatcccgt aaaattgtga 956581 gcgcttcaac gtattgtttt ggcaaagttt cgtataaaga aactgtcacg cggcgcatcc 956641 gctcttttaa agtgagttca ggccagtcct ccagccgtaa tgtatccaag aatctgtttt 956701 tgttaaaatc aggataggat gaccttacat gatggatcaa ctgagatatc agttcttcat 956761 tatatatttc ttttaaatca gccatataaa caccgctttt tcgtttatta tttatattgt 956821 atgggaatgt acgttctgga tcaagtgtat agtcctaaaa attaacaact gatcctacca 956881 cggatataca aaagttggtt acttttttta gttaaaaaaa cccttgtcat cggaaaggaa 956941 aactgagata ataacattga aagcgcctac acttacctat ttcaaatgga tacggtcgca 957001 tatcatgccg ttatatagag gggataagca acagagagta agtgttcgga gcgcatcatt 957061 ggtcaaacaa ggggttcctg atacatgatt tttcgtaaat cgaaataacg atattaggga 957121 gaatggctgc ttcgatcgta tcctatcaac aagccataca taaagtctgc tgagccaggc 957181 tttttttgct ttaagaaaag gttgttctaa acacagagac agggtcatat cctatacaca 957241 agtacagtca tcaaggaggg ggacatctct gtgtcaaaac aattgcttgc cttaaatata 957301 gatggagcgc tgcttcggtc gaacgggaag attcatcagg caacgaaaga cgcgattgaa 957361 tatgtaaaga aaaaagggat ttacgtcaca cttgtgacca accgtcattt tcgctcagca 957421 cagaaaatag cgaaatcgct aaagcttgat gccaagctga tcacccatag cggggcatat 957481 atcgctgaga aaattgacgc cccgtttttt gaaaaaagaa tttctgatga tcataccttt 957541 aacattgttc aagtgctgga gagctatcaa tgcaatattc ggcttcttca cgaaaagtat 957601 tccatcggaa acaagaaaaa ggtgaattcg aatttattag ggaaagcact cattcatccg 957661 tctgacccga tcttttatcc agtccagttc gttgaatcat taagcgatct cctcatggat 957721 gagccggtga gtgcacccgt catcgaggtg tacacggagc acgacattca gcatgacatt 957781 acagaaacga ttacaaaagc cttccctgcg gtggacgtga ttcgcgtaaa cgatgagaaa 957841 ctgaatatcg tcccgaaggg tgtctcgaag gaagcgggtt tggccctcgt cgcttcagag 957901 ctgggcctga gtatggatga tgtcgtggcc attgggcatc agtatgacga tctgccgatg 957961 atcgaacttg ccggtcttgg ggtagcgatg gggaatgccg ttccggaaat taagagaaag 958021 gcagattggg ttacaaggtc caatgacgag caaggtgtcg cttatatgat gaaggaatat 958081 ttccgaatgc agcagcgaaa aggatttctt gataagttcc acatgaaacg tgtgtaaaaa 958141 agccgctcgc gccctgacag gtgcggcggc ttttttgccg gattgatttt agcagtttat 958201 ttctgtacac taaagaaagt tttgaatctg ataaattagg tgatgaagtt gcaaattaaa 958261 atagaaggca tacatgatga ccgcctgcat cggcctctgc aaaatattgc aaatttgttt 958321 tatgaagagt gcgagcttgc gtatggcgga gaggagcccg cagattttgt catttcttta 958381 gcgttgtcac aaacggatga gcatgtgacg gtttctggag aagtgaaggg tactggcata 958441 aaggaacagc atacaaaatt cttttctcca gacatgactg aaaaagaagc ttttaagcaa 958501 gtgaaaaaca caatttctta tgtgtatctc aatcttcttc aggcgcatac gggcattacg 958561 cagaagtggg gaatcctcac aggaatccgg cccacaaagc tgcttcataa aaaactgcaa 958621 agcggaatgt ccaaggagca agcgcatgct gagttgaaaa aagactattt aattcatgat 958681 gaaaaaatca tgctaatgca ggaaattgtt gaccgtcagc tggcggcagt gccggatttg 958741 taccgagtaa aggatgaagt cagcatttat atcggcattc cgttctgccc gacaaaatgc 958801 gcgtattgca cattccctgc gtacgctatc caaggacagg cgggcagagt cggctcattc 958861 ctatggggac tgcattacga aatgcagaaa atcggtgaat ggctgaagga gcatgatgtt 958921 aaggttacaa ccatttactt tggcggcggg acgccgacaa gcattacagc ggaggagatg 958981 gatctgctgt atgaagaaat ggtccgctcc ttcccggatg tgaaaaacat tcgtgagatt 959041 acggtggagg ccggtcgtcc tgacacgatt acagaagaaa aactcgccgt tttaaacaaa 959101 tatgacattg atcggatcag catcaatccg caatcctacg aaaacgaaac gctaaaggcg 959161 atcgggcggc accatacggt tgaagagacc attgagaaat atcatctgtc acgccagcac 959221 ggcatgaata atattaacat ggacttgatt attggtttgc ctggggaagg cgtgaaggag 959281 ttcaggcaca gtctttcaga aacagaaaaa ctgatgccgg aatcccttac cgttcatact 959341 ctttcattta aacgggcgtc agaaatgacg agaaacaagc ataagtacaa agttgccggc 959401 agggaagagg tttctcaaat gatggaagac gcggtagcct ggacgaaaga gcatgggtac 959461 gtgccttatt atttataccg ccagaaaaac attcttggaa accttgaaaa cgtcggatac 959521 tctttgccgg gacaagaaag catctacaac attatgatta tggaagaggt gcagacgatt 959581 attggcatcg gctgcggcgc tgctagtaaa tttattgatc gggatacagg gaaaattacg 959641 cattttgcga atccgaaaga tccgaaatcg tacaatgagc gcttcgagca ctacacggac 959701 gaaaaaatca aatatttaga gcagattttt gaaaaaacga caaagcagca ctgattacag 959761 tgctgctttt tttatccctg tttttttgcg ggctgaacct caggcttcca tttaaatacc 959821 ttgttcagca agcggtaaat tcgttttgat tcctttgtga caagcggtcc caaaatcgcc 959881 agaatgagga catataatgc ggcaaacggc tttaatgtgg ccgacagtcc gccggctatc 959941 ccgagattcg caacgataat cgaaaattct ccccgcgata cgatcgtcag cccgatattc 960001 gatgaagcct tatgagaaag ccctgcgcgt cgtcctgcca ccattccggc gataaaattt 960061 cccagaatgg tcaaaatcac tgcacccaac gcaagccaaa ccgcttcacc aagcgaaaac 960121 ggatcgatgc tgaggccgaa gctgaaaaag aacatcgcac cgaagaagtc gcgaaacgga 960181 acaacgaggt gttcaatcct atcggaatgc tctgtttctg aaaagaccaa accgagcagc 960241 agcgcgccga ttgcttctgc tacatgaatc gtctctgaaa aaccggcgat aaaaaagagt 960301 gctgcgaaaa tgacgataat aaacacttcg tttgagcgaa tgtccaacag tttgttcaac 960361 agcggcggga gttttcttgc tgcgataaaa aacagcagca tataaccgaa ggcgatcaaa 960421 atggacaaga gtgcactccc tacggatgtc gcatcaccta gtataaggcc ggaaacaacg 960481 gacagatata cggcaaggaa aatatcttca aacatgatga tgccgagaat caattcggtt 960541 tccgggttgg cggttctttt taaatcaacg agcacttttg cgacaatcgc acttgacgag 960601 attgtgatga cgcctgcgag gatgaggact tccagaaagg aaaatccggt gataaacccg 960661 taaagcagtc cgaggctgaa gttaatcaaa atataaatcg tcccgccgac cgcgattgat 960721 tttcctgatt tgattaactt cccgacagag aattcgagtc cgagatagaa gaggaggaac 960781 agtacgccca ttcgcccgaa aaactcgatg atttcactgc tttgaataaa tgttagatca 960841 ataatcccca ttttcggcgc gtgcggtcca acaagcattc ccagcacaat cagaaacgga 960901 ataatcgaaa atttaatttt attggcgatc acactggcga ttgccacaag cacaagtgca 960961 gttccgactt caaatacaag atggtccatc ggggctcaca cgccctctcc agaaagaaaa 961021 tcgtgaatca gtttcttcag atgctttctc tcacctgaga ggacaagggt gtcattttct 961081 tcaataatcg aatccgctcc gggatttagg agcttttcct ggttgtgttt gataatcgca 961141 ataacagtga catcgtaatt ctggcgaaca tcaagctcac cgagtgtgcg tccgatcgat 961201 ttggcgcctt tttcgacctt aaaccattca ataataagat cgctgaaggc catttcgatg 961261 gactccagag cttgcggttt atagaccatg cccccgagaa tagctgcaat ttgccttgct 961321 tcagaatcat ccaatgaaat atttgaaaga agctcatccg ggtcccggtc attaaaccgg 961381 taaatttccc ttcttccgtc atcatgaatg ataatcgtca ttttttcgtg gcttcttgtt 961441 tcgatttcaa actttttgcc gatgcccggc agatcgtttt ctttaatatt caatgaaaat 961501 ccctccgaat gtagtgttgg cagtatgggg tgagttacaa ataaaacttg agcaaattat 961561 attcggaggt aattagactg gtatttgaca gggacggcca aagccttttc cagcctgttt 961621 atcagcggtt cgtcaagtgg tttgacagag agctgcctga cagactgcgc cagcgggctg 961681 tactctttga tcagctcagc cgggtgcatg ctgcccggcg atggcgtttt tgccgattgt 961741 gtttcctgcg gatatgaaga cataggcaca tagctgtcag tgcttgcttc aaactgggaa 961801 ggcagaacca cgtccgaagg gggaaagtac accataaata aacttaacag aaaactgatc 961861 agcaatttat ccatgttcct ttcctccctt ctcatcaaga tatcccttct ttttcactat 961921 ataaaacttt atgtttccat tcaaacaata tgcatttttc agtatctatt gaccttgaaa 961981 aataaaaagg tttatttggg gatggcgggg aatgtatagg agaaagaaaa aagtaagcgc 962041 atacatggag gtgcttttaa tggagtttgt tcaatatgca tgtaatgggg ccgttgcaga 962101 gattatcctg aatcggcctg atgcccatca cgccctgaat gaacagatgc tgtctgaatt 962161 gaaggaggca gtcgaaatgg cggctgcaag cgaggcgctc atcgttctcc tgagaggaag 962221 cgggaaaggc ttttcggccg gcggtgatat caggatgatg acgtcagagc atgaccctga 962281 ccaatttaaa cggctgatgg atacgattga ggctgtcacc ctgaatttat atcagatgaa 962341 gaaagtgaca attgcagcca ttcatggtgc tgctgcggga ctgggcctga gtttggcgct 962401 ttgtgcggac attgtgctcg ctgaaaaaaa cgccgttctc gcgatgaatt ttatcggcat 962461 tgggcttgtt ccggacggcg gaggacatta tttgctgaag aaaagaatcg gtgaagcaaa 962521 agcgaaaaaa ctgatttgga gcggaaaaaa actatctgcc tcggaagctg ccgatatggg 962581 gcttcttgat gggacatttg ccggagaccc tgccgaaggc gcaagaccca ttatcgaaac 962641 cctgttggcc tcccctcttt tggcgatgat cgaaacgaaa ggtatttttc aaagcctcca 962701 aattgaagaa ctgaaaaaag tgctatccct tgagcgcagc gcccaagaga gaatgagaag 962761 gaccaaggat caccaagaag gaatccgtgc ctttttagaa aaacgggagc cgaagtttca 962821 agcgtaacag atcagccgga aagctgatca tctgtgaaac aaaatcagct ttccggctgc 962881 attgactaaa cgatgagtat gactatgaag ctctttttct tttaagaggg cttcaccatg 962941 cgtttttgcc gcttcttcat gttctgcctc gaattgctcg tttaccagcg tgttccccga 963001 aggatcaaat acggtaagga aataatcagc catcaggttt ctcctccatt ttaaggttta 963061 tcagtctttc ttcatttata ttctaaaaag gaaatcaaaa tcctttatta tgctttatcc 963121 aaaattagta tataatgggt cagggaagga ggagattcag tgcttacaat tgatcacgta 963181 acgaagacat ttggagatta taaagccgtt gacggattgg acttagatat tccggaacag 963241 caaatgttcg gtctattagg cgcaaacgga gcgggaaaaa caacaacgtt tcgcatgatc 963301 ctaggattat taagcattac ggagggctca atcagctgga agggccgtcc tgtgaattat 963361 catatcagca acaaaatcgg ttatttgccg gaagagcggg gcctttatcc gaaaatgaag 963421 gtaagggatc agctcgtcta tcttgccaga ttaaaaggga tggagaagcg agaggctgta 963481 aaagagctcg ggacatggct tgaacgcttc aatattacag attacgagaa taagaaggtg 963541 gaagagcttt cgaaggggaa tcagcagaaa atccaattca tttcggcagt tttgcataag 963601 ccggagctcc tgattcttga tgaaccattc agcggcttgg accctgtcaa tgttgagctg 963661 ctaaaagagg ccgtgatctc gctgaaaaac agcggtgttt ctattttatt ttcaagccat 963721 cggatggaac atgtggagga gctttgtgag aacctttgca tattgcagaa aggaaaaccg 963781 gttgtacaag gcaagctgaa ggagatcaag cgttctttcg gtaaaaagaa tgttaccatt 963841 cactccgatg acgatctgcg ctttttgcag tcccatgaag gcattcttca atggaaggaa 963901 acggcagacg gcgtcaagct gcagattgcc aatgaagaca tttctcaaga gatttttgcg 963961 atgctccaag gaaaagggtt tatcagaaag tttgagcttg aagagccgtc actgcatgat 964021 atttttatag aaaaggtggg ggccgtctat gaataaattt tggatcatgc tttctcatac 964081 atacaaaaat aagattatgg caaaatcctt tattatttcg actgtcatca cggtgctgct 964141 tgttttagtt gtaacgaatc tggagtcgat catttctttg tttcaaggtg acgatgcgaa 964201 agaaaaaatc gccgttgttg atgaaacaaa cgaattatat ccggtttttt ctaagcagct 964261 gaaagcggtg gatacagacg gcgatcttga tgtgaagctg tcgaagcaat cggaggatga 964321 ggtcacaaag caagtcaaag atgaatcact cgatggcatg ctcatcatca aacgagatga 964381 aaaagggacc atttcaggaa catataaagc gttaacgatt tctgatgaaa gcacgtatca 964441 aacactgcag caggcgctga cgcaaaccaa aacagctgtc ggaacagcgg agctcggcgt 964501 gtcgcaggaa acgattagca gcctttatgc gcctgttact gtggggcaga aggcgctgaa 964561 agaaggggca aagtctgagg aagagcttgg ccagacggta gggcttgttt acattatgct 964621 gttcgtcatt tatttctcgg tgattatgta tgccagcatg atagcgatgg aggtcgcaac 964681 cgaaaaatct tcgcgagtta tggaaatcct gatctcaagt atgccgccga tccagcaaat 964741 gtttgcaaag ctgcttggta tcgggcttgt cgggatcaca cagcttgcta ttattatagg 964801 agccggctct ctgtcgctta agctgaacca aaagagcgaa acggcttcat ctgtcggcgg 964861 attccttaat ttgaccgacg tatctgcaac cactgtcatc tatgctgtca ttttcttttt 964921 gctcggatac tttttgtacg cgacacttgc cgcgtttctc ggcagtgtcg tcagcagaat 964981 agaggacgtg cagcaaacga tcacgccgat gacgcttttg gttgtcgccg gttttatgat 965041 cgcgatgttc ggtttgaatg cgcctgacgc aggatttatt acggtaactt cgtttattcc 965101 gttctttacg ccaatgatta tgttcctgcg cgtcggcatg cttgatattc cgttctggca 965161 ggcggctgtc ggaatcggaa tcacactgct caccattgtc atactggccg ttatcggcgc 965221 cagaatttat aaaggcggtg tattaattta cggcaattca agcgcgttca aagcgatcaa 965281 acaagcgcta cgtttagcga aaaactgatt ggaaaacagc ctggggattc tcaggctgtt 965341 tctttattga cagaacgtgc attcgcaaga attcggtgct aaaataaggg tacttcatcc 965401 tggaaaggag cagaatgttg actgatctaa cctttattca tgcggcagat cttcatcttg 965461 acagcccgtt ttacgggata tcgcatctgc cggagccgat ttttgcccgg attaaagaaa 965521 gcacgtttgc aagcgtgaga catatgatag acgccgcagt gagagagcac gttgatttca 965581 ttttgcttgc gggagatctg tttgatgaag ccaatcgaag cttaaaggct cagctctttt 965641 tgaaaaaaca gtttgaaaga ctcagagagt gcggaatttc ggtatacgtc atctttggga 965701 atcacgatca tcttggcggg gagtggacgc cgattgaatg gcctgagaat gtccatattt 965761 tttcgtccgc tgttccagaa gaaaaatcgt tttttaaaga aggcaggcgc atagcaagca 965821 tttacggctt cagctatcaa gccagagcat tgatggaaaa ccaagccgcc cgctatcgga 965881 gatcaactga cgcaccgttt catatcggca tgctccacgg cacgctgtca ggatctgaag 965941 gacacgatcc gtattgcccg tttacacatg acgacctcgt gaaaagcggg atggattatt 966001 gggcgcttgg ccatatacat aaacgccagg ttctatctgc cgagcatccg gcagtcattt 966061 acccgggaaa cacgcaagca cgccatataa aggagacggg agataaaggc tattatctcg 966121 ttcatgtgac aaacggagat atatcttatg aatttcagag agcgcatgat gtcctgtggg 966181 aaaaagcggc ggttgatgtg acggaggcaa agaatatgac agccctcttc caaatggtgg 966241 aggacacgtt ttcgaagctg cggaaaaagg ggagccctgt ttgtgtaagg cttgttttac 966301 aagggacggc gccggaatgg ctgctggagg cgccaaaagg caccttggat gagtttcttg 966361 aagctcttca ggaacaagaa gcggaagagg aacgtttcgt ttggcctctt agattggacg 966421 atgagacaga aaacgaagca aacctaacaa accttgatcc tttttttggc ggtttatttg 966481 aagacattga tcgcagcgat ctgtcagacg tgctggaagg gcttgagcgg catccagtgt 966541 atagaaggca cgcggaccgg tttagccaag aggaggtaaa ggaaataaaa gagcaggcac 966601 agataatatt gaaaagacag cttaaggtgc ttgatacatg aggcggtgac agctttgcga 966661 attatatctt tacatatcta ccaatacgga aaattttcca atcggacctt tgacttttcc 966721 gcctctcctg tccaagtcat ctacggatta aatgaggcag gaaaaacgac gatgatgtca 966781 ttcattgaaa gcatgctgtt cggttttccg aaaacgaaaa agtatgaacc gaaaacaggc 966841 ggtgtctacg gcggtgttct tgaagctgaa catcctgagt atggggtgct gaagatcgaa 966901 cggacgaaag ggactgccga aaaactaagc gtgtacacag aaaagggcga agtaaagcag 966961 ggagatgttt taaagcagct gttccagggc acagacaggt cgttgtacaa agccatatat 967021 tcgttcgacg tattcgggct gcaggaaatt cacgccttta atcgggacaa gataggggaa 967081 tttttgctct tttccagctt gtttggtgct gaagccgtat caaagcttga ttcaaggctg 967141 acgaaggaaa gcgaaaggct ctataaacca aatgggcgaa accctcaatt gaatcaggag 967201 ctggaaacgc ttaagcagct ggcagttaag ctaaaacagg ctgaagcaga ggaagcgggc 967261 tatcatcagc ttctcgagga aaaacgaacg cttgaagccc gccttgcagc cgcggaaacc 967321 gaattgaaag agacggcggg acatatccga atgattgagg gagcgattga gcgaaagccg 967381 ctgctaaatg aaaaagcgac actcgaacag gtgattgcag aatttccgga acacgcagga 967441 caatttcctg ctgacggact gcatcagctg gaaaaatatg aatcccatct tcacccgaaa 967501 tcagcacagc ttgaggcgct tcgggtgaag atggcggagt tggacaaaca gaggcaaaag 967561 cttatccccg ataaagaact attggcgaaa gaaacgctga tacaagagct ttcggcagcg 967621 tttcatatgt accaatcctg gggagaacag ctggcagcca ttcaggcaca gctgcgccag 967681 acgtctgcgc agacagcggc agggctggaa cagctcaata aaacggatga aaatgagctc 967741 ctgaatatga acacctcata tgattatgaa tggcagcttc agcaagcggt gcagcaatat 967801 gtacaggcaa gagacagaaa acggcagctt gacgagacgt ttgaacttgc ccggcaagag 967861 ctggaagacg cggaaaaggc cgttcgtgcc gcttcgtccg cgattcttga aaacagccaa 967921 agaaaagata aagaagcagc tcttagagca tatgatgaaa cacaggggca gcaccaagag 967981 caagcgaagc tcagagaaca gctaacgttt tttgaaagac agcaggctaa acagaaaaag 968041 actgtcattg cagctggtat gttgttcatc gttctctttt ctctgctgca gcaatggatt 968101 cccgccataa gtttcggcgc tgcacttatt gtgtattggc ttgtttcagg aaagtcgtct 968161 tctcgaaaca gccgagagac aagacagccc atgacggata tttcaccagc agaagctgaa 968221 atgcttagag aagcgttatg ggaggatgac cgcaataagc agcaccttct cacacagcgt 968281 gcagcgctcc agcaaaaaga ggcggcgtat gaaagggtca tccagcagtt tgaacagtgg 968341 gaagccgaaa tggcgccgtc ctttacacag gttgagcgtt ttatgaatga gctcggattt 968401 aaggaagatc catcattttt gcttgatgca tacagcttaa tgaaggatgt taaaaaagaa 968461 gtgaagaaaa agcatgagct gaccatagaa gcaggcaggc tgaaaaagca ccggagaaca 968521 ttcgaagaac gcgtcagtat gcttcttccc gtgaatcaga gtcaggatat ctccatttcg 968581 gacgcccttc acacattgcg gaaaaacatt gaacgtgaaa aagaaattga gaagcaaaaa 968641 aaggaaattg aaacagatat tcattataca aaggaacaga tgcttgaact tgagcaagaa 968701 atacagtatt tccacgcaca gattgaacag ttatttgccg cggctgctgc aaaagacaga 968761 gatgcgtttt ttgccatagc cgccatcagc aggcaattga aggatacgga gaacaagctt 968821 catcacgtaa acgcacagct tcaaggcggg tacccggagg aacttgaact ggcggattcc 968881 aatacgcttt ctgaattgaa agataagcaa tttgttgaga atgaaagaaa agagcggctg 968941 actgaggaga tcgagcagct ccgcagccaa atcgcactgc tctcagtcaa acaggaacaa 969001 ttagaggctt cgggaatggt ctcagacctc aagcttcaaa ccgaaatgca aaaagaacgt 969061 gtgaaagaaa cggctaaaaa atgggcctcc atacaaatgg tcaaacaggt gatcagaaac 969121 aaattggagc ggcataaaaa aatcgagctt ccgcgccttc tggagacggc aggagaattt 969181 ttccgtcctc tgactgacgg aaactaccaa accatttatt tttccgaaac ggatgattcg 969241 atcatggtta tgcatcgcga tggcactgtc tatcatgcgg aagagctgtc acaagggacg 969301 tgtgaacagc tgtatacagc gatccgcttt gctttggccg ttacgcgcca gggtgagtca 969361 aagcttccgt tccagcttga cgacagtttt gttcattttg atcaggaaag gctgaaacgt 969421 gtattacatg ttctgtatga tttatctgaa ggcggtaggc agattttgta ttttacatgc 969481 catgagcacg taaaagatgc atttcatagc agccaaatca tccatttggt gtcataaaag 969541 aggttctata gctgaaaatc ggtatgtgat atactggtat tatgtaagat acggagggag 969601 ctttaataga atggctaaag ggattatgct acatgaggtt ggcgaacagg tggaccagta 969661 tctattgatt aaatcctcga cgaaagggat tgcaagcaat ggaaaaccgt ttctgacgct 969721 gatgctgcaa gaccagtcag gcgatattga agcgaagctg tgggatgcca agcaaagtga 969781 tgaagtgacc tatgcgccgc agacgattgt caaggtcgtc ggcgatgttc accattatcg 969841 cggacgcacc cagctgaagc taagaaatat cagaccggta agcgagcaag aaaacgtcaa 969901 tattgatgat tttttagaaa ccgcgccgat tccgaaaaat gaaatgatgg ataccatcac 969961 tcaatatata tttgaaatga aaaatccgaa tatccagcga atcacaaggt ttttggttaa 970021 aaaacacgaa gctgagttta tggattatcc ggcggctacg aaaaaccacc atgagtttgt 970081 ctcaggtttg gcgtatcatg ttgtctctat gctgaacctg gcgaaagcaa tagcagattt 970141 atatccttct cttgatcgtg atctgcttta cgccggtgtt atcctgcatg atcttggaaa 970201 agtgaaggag ctgtccggcc ctgtttccac ttcatatacg gttgaaggca atttgctcgg 970261 ccatatttcc atcatggtga cagagctttc aaaagcggct gaggagcttc aaatcgattc 970321 tgaagaggtg ttaattcttc agcatttgat tttgagtcac cacggcaaag cagaatgggg 970381 cagcccgaaa ccgcctatgg tgaaagaagc ggaaattctt cactatatag acaatctgga 970441 tgcaaaaatg aatatgatgg acagagcgct tgagcgcgtg aagccgggcg agtatactga 970501 acgtgtattt gcactggaaa accgttcctt ttataaaccg acatttcata aataacttaa 970561 aaaggactga tgctgacata ttcagctcag tcctttttga tgcgtctttc ccgcacataa 970621 ctcgtctcat tcccgcatat ggttaagaat aaagaatcta tgcaaagggg gaggagcccg 970681 tgttattttt tccgtggtgg gtgtatcttt gtattgtagg catcattttc agcgcatata 970741 aacttgtggc ggcagccaaa gaggaagaaa aagtagacca ggcttttatt gaaaaagaag 970801 gacagattta tatggagagg atggaaaagg agcgagaacg ccgcagttct cagcagcatg 970861 aagaagaaaa tcaaaaccat tccatcgcat aaaaaaagct gtgcggctca atgagccgca 970921 cagctttttt tattatttag aattgcttga agatgaagaa gtgctgttgc ttgttgaaga 970981 tgtattaaat gtgtctttca gatctttatc ttttacttcg atgtcagcct tcttcatgac 971041 tttttgaaca gcttcctgaa cagctgcgtt gtcatttaat ttttgttcaa gcacttcaga 971101 tttcagttct tttttcatat catcatattt gccgcgttct tctgtctttt taatgatatg 971161 gtagccgtat tgcgttttga caggatcact gacttcacct gtttttaatt tgaatgcagc 971221 tttgctgaat gtttcgtcca tttggccttc ttttgcgaac cagccaagat ccccgccttt 971281 tgaagcagag ctgtctgttg agtattcttt cgcaaggtct tcaaacttct cgcctttttt 971341 cagctttttc tctacttctt cagctgtctt tttatcagca acaaggatgt ggcttgcacg 971401 gattttgcct tttaagcctt cccagtactc tttgatatcg gcgtctgtta ctttgatgtt 971461 atctttagcc gctttttgtg tcagcaattc atattttact tgttctttca ggtaatcttt 971521 gccatattgc ttttcgaggg cagtatattg atcgccaagc tgcgttttgt attctttcag 971581 cttgttgtca atttctttat ccgaaacttt atacttcttg tccaatactt tttcttgcac 971641 tagctgtgtc agtacgcttg cgccagctgt tttcttcatg tttgtgtaaa gctcgccttt 971701 tgtgacatcg cctgcgtctg tttttgcgat aacttctttg tcgccgctgc tgcaagcact 971761 gagagcgagg atgcttgtag cagtgatagc tgctattgcg attttcttca ttgttttcaa 971821 acactcctaa tcattccaaa ttaaattacc tatgcgtatc ataacatatt gtggctttct 971881 gtaaaaagat tttaaataaa gggcattcgt ctagtcaaac ttttgctgat gacatactta 971941 tatattgatc aagaaaagga ggtatgtaac atgagcggag gatactctaa cggattcgcg 972001 ttgctcgtag tactgttcat tttgcttatc atcgtaggtg cagcttacat ctactaagca 972061 gcccgaggat cgcttgcaac ataagcgatc ctttattttc actagcgcct aatcgtttca 972121 aacatgaatt gcataacatg taattggtaa ataaagctta ttacaggagg tgctatttaa 972181 gatgggtgaa gtatttgcag gcggattcgc tttattggtt gtgttattta ttttattgat 972241 tatcatcggc gcttcttggc tgtactaatc aacataaaaa agcatagctg cttaatcagc 972301 agctatgctt tctttcgtat ttacactgta aaggagatct ccacaaacga agagatcagt 972361 aaaattaata tagatacatt aataaatcgg aataccttat cttgccgctc ttcaggaatc 972421 tctctgacaa ggcataatgt attggtgagc ctgtttatga aatataaaat aaacacggca 972481 gccacgataa aatagaataa aatgatggga gattccccct ctctctgaac tgtcccatat 972541 tacattacca aatatttatt aaaaaagata gaatgcaaat tgaaaaatcg ccaccagcac 972601 cagggtttga ctacttttca acaagaatat ccaagccgtc agcttcctga tcaataaaag 972661 cggttttcgg tgcttttatc agcttgagag ccagcaggaa atcaggcaga cagtagccgg 972721 cgtgaatgcc cgagatcatg caaaaataat gagcgtgatt cggaaatgcc agtgctgcgt 972781 aaaacaatac cggtgtaatc agcaagaacg ggctgacgag tgaaatcagc attgttgttt 972841 ttggtatacg tttccatgtg cgcatgcgca atatgtaaaa ctttttttct atttttcttt 972901 ttttgcagat gattggcagg acatggatga ctttatgtac aaataaaata acgacgagca 972961 aaccgccgaa taaagataca tattcatcgc ttaagcttgt gccaggccgc agcagctcaa 973021 aagctaaaaa ggtagatata aaaaccaaaa tcataaaaca tacagcagtt aatattatgc 973081 gaacggcgcc ataatccttc atgagattta tggtcttcca gcaattcatc aaagtcatcc 973141 ttccatacat cttgaataga atctcaaaat aatttactcc tcccaagaga aaaaatcaat 973201 gcttttttaa gaaaaaatat catccggcag gtattttttt gaaacaagca aacaaactgc 973261 gaaatatggg gttagaactt tcttctcagt gaattatcag ctaaaataag attaaagata 973321 gaaagaagtg gtgtggatgg attcgatgga tcatcgcatt gagcgattag aatattacat 973381 acaattatta gtgaaaacag tagatatgga caggtacccc ttctatgcgc ttctcattga 973441 taaagggctg agcaaggaag aaggggaagc ggttatgagg atatgcgacg aattgtcgga 973501 agagctggca acacaaaaag cgcaaggatt tgtaaccttt gataagctcc ttgcgctttt 973561 tgccggacag ctgaatgaaa aattagatgt tcatgaaaca atttttgccc tgtatgagca 973621 ggggctttat caagagctga tggaagtctt tatcgacatc atgaagcatt ttgattaact 973681 gtttacaggt tcgagctctt cagccggttc atccgccgca ctgtcctttg cttttttctt 973741 caattttccg tttacgcttt caaagtcatt gtcaatattg gtgagtgacg tttcgaaaat 973801 ttccataaaa tcatcgccgt agatatggcg tatcatacac atcatttctg ccacttcagg 973861 aaattttccg aataaatgat ataaaggctg tgacccttta aaaacagcgt tgcgtgtcgg 973921 atcaaattcc tcaagcaagc tccagaatac ctcggtacct tcctcagtca attggacata 973981 tgtgttccgt ttatcattca gccgtttgga gaaccttaaa tatccccgtt cttccagctt 974041 ttttgaaaag ttgaatgcgg ttgatacgtg catgaccccg aatttcgcga tttcagaaat 974101 ggaagctcca ttcaattgat acgcaatcca taaaatatga tgctcattaa tattcaggtc 974161 atacggtttg agccattgct gccaatcctt ctcgatcgat ttccaaagag ccttgctaag 974221 ctgagccatt ttctgggtga aaaccagagc ttctttcaca tcatagggcg gttccactcg 974281 attcattacg tcacctgctt ctctttttct ttttctctat tatgccaata aaataaagat 974341 taataaagat gaaaatgtaa gaatttttta ataaattcac aaaccattgc gacgaaaggg 974401 tttttcggcc aaaaaaaata cgggtccaat tttggcccgc atttttttct tttgaatagg 974461 atattagttt tgtaaggttt tctccagctg tctgattttc tcttcgatat cggcaatttc 974521 tttttgcaga tcctgctggt gaggcttgat ctcttcctgc cattttttaa ttgatgtttg 974581 gagctcgccg cccacgtctt taataacatc cgtgctttct tttgccgctt tgatcagctg 974641 gtcttttaat gcaagcccgt ctgactttaa gcgtttgatt gtttcttcaa aagaatcata 974701 attggttttc attttttcac gcagctgctt tcctgaggaa ggtgcagtaa gaagaaccgc 974761 tgctcctccg atgatgccgc ctacgaatag tcctgttaat agagaacgtc cgctcgccat 974821 tacaatcacc ccgtcttttt cttcaaaata ggattcattc agcatttttc atttttgttg 974881 aaagcctgaa cttctataca tagcttgctt tattttagca tattttttaa gtgaaaagga 974941 gggagaaggt tgtctgtctt tttgattgta ttatcctgca tcacccttgc cttcgcttca 975001 ggcgctgttt actatatcaa acttctcagc caggctgctt cttatccgcc caagagggtt 975061 atccggcaga aagcgcttgt ttgttcaacc ggaaccgcct ttacactatg tcttatcttt 975121 ttcacaaaac tcctcgctta aaacatgctg acatgctgcg ggcgctctgt tcaaaaaaac 975181 ctctcccgga agcggaagag gttttgtgtg acaattattt agcagcttcc ataaagcttg 975241 aacgccttaa aatggtttgc acaatcggat aaataatgat cattgagatt gtattcagca 975301 cagcggccgg cagaacaaca gccgcgaaca atgcggcgaa accgcccggt aaaccgacga 975361 tcaataaagc tgacgataga aacacaattc ctgataagat ggtcccgatc actgtcagca 975421 cagcggctgc acctgttttc cggctctttc tgaacaagag aaacagggag aagaacagaa 975481 acgctgatac gggtttatca atgatgttag ggatctgtcc ggctggaaac gcggttgtaa 975541 gcgcggaaat gattccggtc acgatcccga tgacgagtac attttgcacc cgcgggaaca 975601 gcagaatgcc catgaacatc atgatcagca tcatatctgg tttcatgccg cctaaaaagg 975661 gcggaataat ggaatgaagc gctgcgccga ttgcggcaaa cagagccata atgactaact 975721 cttttgtttt cataactatg ctctcctctg ctaagctttt tgccctccaa taatatgctc 975781 atcatttatt gcgaaggctt tacagaatgt gttatgcaaa cagtatacca aacggacggt 975841 ttgcatagcc agacttttta ctcattttcc tgctggaatt tcttcatgaa cgcagctaat 975901 ttttcacagt cttcgagaga gaccgcgtta taaatagaag cgcggcagcc tcccaccgaa 975961 cggtgtccgc caaggccgat catcttcgca tcttttgctt tctgaacgaa tgttttcgtt 976021 aattcgtcat cccgaagcgt gaatgtgaca ttcatgcgtg agcggctgtc ttttctggca 976081 tgtcctttat agaagccgtt gctttcatca atacagctgt agagaacctg cgctttttgt 976141 tcattgcgct gttcaacagc ttccacaccg ccgttttcct tgagccattc cagaacgagg 976201 ctcagcatat aaatcgcaaa tgtcggcgga gtgttgtaga gtgaatccgc tttgacatgc 976261 gtggaatatt tcaagatttt tgggacgttc gcattttcat tttgcagcca gctttttttc 976321 atgatgacta cagtcacgcc ggaagggccg aggttctttt gggcgcctcc gtagatcaca 976381 tcaaatttgg acacatcgat ttttctgctt aaaatatcgc tggacatgtc ggctacgagc 976441 ggaattggag aattcggaaa ctcctgccac tgagtgccga aaattgtatt gttggatgtg 976501 atatgtaaat atgcgccgtc ttttacatcc gtaaggtcaa cctctggaat ataactgtaa 976561 ttgtctgttt cacttgtagc ggtgatagac gtgttcccga acagtttcgt ttctgccagt 976621 gctttttcag accaagcgcc ggtcatcaca aaatgtgcgg ttttttcagg tgttaaaaag 976681 ttcatcggaa gcattgagaa ttgaaggctt gccccgcctt gaagaaacaa gatatcgtaa 976741 tcttccggaa tgcccatcag ttcgattaag aggcttttcg ctttttggtg caccgcttca 976801 tactctttgc tgcggtggga aagctccata acagacatgc cggattcgtt aaaatcaata 976861 aattctttct gtgctttttg cagaacttcc agtggcagcg ctgcaggacc tgcgttaaaa 976921 ttcgttgtac gttccattat gatctctccc tgttttccac gttaatgtat aaaataatac 976981 aattatccta tcacaaaaat tcagtttttt gataaaaaat tagaattatc aaaagaaatt 977041 gacggatgtt tgcgaaatgt tcacaaaata aaataacctc atcttatgat gaggccaggc 977101 gttttgcgat agaggaagag atgttctgca gatcctccgg tttataatca tcagcatgcg 977161 ttttccaaac cgctccgaat ccatctcctt ttccgtagcg agggataata tgcatatggt 977221 agtggaacac agattgtcca gctttttcgc cgttattgtt cagcgtattt aagccgatcg 977281 gttcaaattc atcccggata gcgcgggcga tttttggaac agcatggaaa tattgttttg 977341 ctaattcatc tgtaaattca tatacattct caatatgtgt tttcggaatg acaagcgtat 977401 ggccttttgt cacttggctg atatcaagaa aggcaagtac atgttcatct tcatacacct 977461 tcgctgatgg aatgtcgccg gcaataattt tacaaaagat acaattctct gcacaatgca 977521 tgagggttcc tccttatgaa attgtttagt atgtatacat tcatcgtacc acagaaatgc 977581 agaaaataga aaacaggatg aacggcgagc gttcaccctg aatgcagagg aagagcttat 977641 atgaagaaaa tgtgttatgc ctttggtaag cacctcattt gtcaataaaa tgaagacttg 977701 tttaatgcct aacgattcct gcgataaaca cctcatttga caatttgctt catacatgaa 977761 gaattcatca attcagtgaa gagaaatggt ttgagcattg gacatgttta ttttctatcc 977821 aactgtttct aagacgtctt tgacaaacac ctcatttttc agttgatatg cttttcctct 977881 acaactttta tgatgtccag aaccctgtct ctttatgaca gcaaattcat catttgttaa 977941 aagggaattg tttcaaatca ggccttgttt ttggtactat gaagaaaaac actataaggg 978001 gagaaactat gtctctgcta tcggtaaaag acttgaccgg cggatataca aggaatccgg 978061 ttttaaaaaa cgtatcattc acccttgaac cgaatcaaat tgtcggctta atcgggctga 978121 atggtgctgg taaaagtaca acaatcagac acatcatcgg gctgatggac ccgcataaag 978181 gttcaatcga attaaacggt aaaacgtttg ctgaggatcc ggaaggctac cgttcacaat 978241 ttacctatat acctgaaaca cctgttttat acgaagaatt gacgctgatg gagcatcttg 978301 aactaacagc catggcatat ggactgtcaa aagaaacgat ggagaaaagg ctgcctccgc 978361 tactaaagga attccgaatg gaaaagaggc tgaagtggtt cccggcccat ttttctaaag 978421 gaatgaagca gaaggttatg attatgtgcg catttttggc agagcctgcg ctctacatta 978481 ttgatgagcc ttttctaggg cttgatccgc ttgccattaa cgcgctgctt gaacggatga 978541 atgaagcgaa aaaaggcggg gcgagcgtgc tgatgtcaac acacattttg gcaacggcag 978601 aacgctattg cgattcgttt attattttac ataacggcga ggtgcgggcg cgcggcacgc 978661 tgtcagagct cagagagcag tttggaatga aggacgcggc gctggacgat ttgtatcttg 978721 agcttacaaa ggaagacgct ggccatgaat aatatgcttg atatttggca gtcgcggctg 978781 caggagcata tcaaagaaac aagaacatac atgaaatata tgctcaacga tcacctcgtc 978841 attgttttga ttttttttct agcgggcgct gcaagctggt acagcaaatg gatacgggac 978901 attcccgctc actttccgtc cttttgggtg atggccgtgc tgttttcgct cgtattgaca 978961 agctcttatg tgcgaacgct tttgaaggag gctgaccttg ttttcttatt gcctcttgaa 979021 gcaaaaatgg agccttactt gaagcaggcg tttgtctaca gctatgtgtc tcagctgttt 979081 ccgctgattg cgctgagcat cgttgcgatg ccgctttatt tcgcagtcac tccgggagct 979141 tcgctcgtat cgtatgccgc ggtctttgtc caactgttgc tgctgaaagc gtggaatcag 979201 gtaatggaat ggcgaacgac tttccaaaac gaccgcagca tgaaacggat ggacgtcatc 979261 attcgctttg cggcgaatac actcgttctt tattttgttt tccaatctgt ttatatgtat 979321 gcgcttctcg tctatgtcat tatggctgtt ctttatctgt atatgtcttc cgcagcaaaa 979381 cggaaaacat ttaaatggga gagccatatt gagtccgaat tgagacgaaa gcagcgtttc 979441 tatcggattg ccaacctgtt tactgatgtg ccgcatttgc gaaagcaagc caaacgcaga 979501 gcttatctcg actttttgct gcggcttgtg ccgtttgaac agcgcaaaac atttgcctat 979561 atgttcaccc gcgccttttt gcgttcgagc gattatttgg gcattcttgt cagattaacg 979621 atcgttttcg cgctgatcat tatgtatgtc tcagccagcc cgctgattgc cgcggttttg 979681 actgtgtttg ccattttcat tacgggcatt cagcttctgc cgctcttcgg tcactttgac 979741 catctggcgc ttcaagagct gtaccctgtg caaaaagaaa caaagctgaa aagctatttc 979801 tctctattaa aaactgcact tagtattcaa gcgctgctga tgtctgttgc atctgcctat 979861 gcagccggct tgaccggttt tctgtacgcg ctgatcggtt ctgccgttct gatttttgtt 979921 gttttgcctg cttatatgac gaccaggctg aaaaagcacg gaaagctgtg aactgaaaag 979981 aggtaatcaa atgacagata atcagctgct gatgcaggaa gctttggaat ggaaaatgca 980041 ttttttgcga aaggattcca tgtttgaacg cttttcgaag cgtgtccaga cgaaggtgaa 980101 tgaacggatt cctgaaaaaa tccatacggt cgtcaccgag agtgtgaaaa aaatggtaga 980161 agcgacaatg gccggctcta atatcatcac ctataaaaag gatacaagtg cactgtcgct 980221 cagtgaaaaa aacgaattgg cgaaaaaaac gattgtttct tatcaaaaag tggcagctgc 980281 tgagggagtc ggcaccggag cgggcggcat ttttttaagc attgctgatt ttccgctgct 980341 gctttcaatt aagatgaagt gtttatttac cttgtcttcc atttacggct ttgatgtcaa 980401 ggatgcacaa gaaaggatat ttttgctgct cgtgtttcag cttgcgtttt cgagtgatga 980461 tggccgtaag tcgctttttt ctgtcatcga aaattgggag acggagaaaa agagcatcga 980521 ctggagagtg ttccagcagg aatatcgcga ttatatcgac gtcgtgaagc tttttcagct 980581 tttgccgggc gtaggagcgg cagtcggcgg aattgccaat tataagctgc ttgctcagct 980641 tggagaaacg gcaagacatg tttttcatct gaggatatta aaggaaacag ccggagaata 980701 aacactccgg ctgttttttt atagctgatg ataggtgatc gcagcgccgg caaggacctt 980761 ggccgctgtc agcatggctt tttcgttgat atcaaatttc ggatggtggt gggaatagac 980821 tcgctctggc tgttcgggag cggcgcctgt aaagaaaaaa gtgcccttca cgttttgtaa 980881 gtaataagca aaatcctcgc cgcccatttg tggttcaccg tcaatgacct gctgaacgcc 980941 ctcggtattc tttgcggtgc tcaccaagtg gttcgtttct gcaggatggt tcacaaccgc 981001 tggataaccc tgttcatagg tgtactcata ggacgcgccg tgcatgctgc atattccttt 981061 tacaaccgct tcaatttctt tctccagaat gtcccggaca ttttcatcaa aagaacgcgc 981121 tgtgccgatg agtactgctt ggtctgcgat gacattaaac ggattgtcgg cgatgaagga 981181 gcctgtcgaa atgacggcgg attgaatcgg attgactttg cggctgacaa tgtgctgcaa 981241 agaggaaacg atttgcgaac cgattaggac ggcgtcttta gtatcatgcg gatgagcgcc 981301 gtggccgccc tttccgaaga ctttaatcgt aaatcggtct gccgccgcca ttacggcgcc 981361 ggggcggcag agaatagttc cgagcggctc agttgcccaa agatgagtgc cgaatatcac 981421 atccgtgttt tcgagacatc cgtcatcaat cattggcttt gcgcctccag gataatattc 981481 ttctgcatgc tggtggatca tcacaaatgt tcccttcagt tcatgtctgt tttggtgaag 981541 gaccttggcc actgcgagaa gagctgcggt gtggccgtcg tggccgcatg catgcatgac 981601 accaggcact ttggaggcgt aagggacatc tttttcatct tgaatgggga gagcgtcaaa 981661 gtcggccctc aaagcgactg tagggccggg ttcgcttcct tctatatttg ctaaaacccc 981721 tctaccgcca acgtttgtgc ggattgggac tcctaacgat tcataatagg aagcaataaa 981781 tgcggcggtt ttttcttctt gaaatgagag ctcaggatac atatgaaaat ggcgcctgat 981841 ctcaaccatt tcttcaaaac agccgtcgag ctgtttgttt atctctttct gcagtgtgga 981901 tatggacaaa gccgcttccc ccttttctat gcttttccat gattgtatag aaaaagtctg 981961 aatatttcaa ctcatgctgt tttaaagcat catcacagct gcgagggttg tcaccaaaag 982021 gccaatcgcg acgggaatga agttttttct ggcaagctca aaaggatcaa ctttgcaaat 982081 ggccgcggcg ggaatcaaag cccatgggac cagtgttcct ccgcccaccc agatggcaga 982141 gatttgtccg agcgcggtca gaatagcggg atcggcatgg agagcggacg aaaagagctt 982201 tgcgatggag ccggcgagag aaatgccaga aaatcctgag ccgtcaaggc ctgttatggc 982261 tccagcggca gttaatgcag tggcggcaag ctcctttgac ataggcatca tatgggataa 982321 agcaatgcca agatcgttga caatgccgtg ggaaccttta gggagtgaag tgcccagtat 982381 gctttcatag cctgagtcgc caagataaaa gaaagcggca atcgggatga cggggccgaa 982441 aaccttaaaa ccgaacttaa atccgtcaat aaaatagccg gtgatttttt caagcccttt 982501 atgcttatac acgaaaaaat gaacggtaaa gaggatacaa attgcagacc cgccaattaa 982561 cgcggttgca tcatttcctt gtaggttaaa caagagcatg caggcgatat ctgcaagaaa 982621 ggcaagcgga atcaaaaaag ccagtatgga ccgcaggcgt tttggcaagt acagcgagtt 982681 gtcttgttcg ccggaaagaa cgggggaaaa agaagtggga tgctcctgtt ttttgcgttc 982741 gcgctgaatc atgataaagg cagcagttgt tgttgtcaca cccataatca gcacaagcgg 982801 aatactggcc gagacgacat caccgactgg aatgcctgct gcatccgcag tcagctttgg 982861 cgccgcctga atgacaaagt ctcctgacag ggcaaaaccg tgtccgaata agttcatggc 982921 catggccgcg gcaagaggcg tcaaaccggc acgtgcggct gcggggagca ggacggcgcc 982981 gatcaaagcg acacccggag aaggccagaa gaatagagaa atggcgaaca tcaggcctcc 983041 aatcagccaa taggcagtca caggccctct cacaaggctt gcaaagggag aaatcatcgc 983101 ttcatttatc cctgtttttg ttaacaaatc actcattgaa acgataaagc aaatgatgaa 983161 aatcgtgggc agcagttcgc cggccgcata gataaagctg tggaataaac tgctgacaga 983221 agctgaaagt gaatggctgg cccatagcga tatgataaaa atgccgaata gagaaataaa 983281 tgtcgtgtct tttctcagca gcataaatag gataattgca ccgataaaaa acacatacag 983341 aacatggaca ggcaaaatcc cgacttccat catcgatcac tccttccgct tacagattat 983401 tcataggcgg gcggaaggtg ccgggacaga ggggagggtt atgatggaag atgaacattg 983461 atctgtttca gctgctcaat cagatgatgc cttaatcctc tattcgcttt ttgcagatgt 983521 tttgggaagc attcaggaga aaaaatgacg cacccttcag caagccagtt ttttctatag 983581 gcgatgatgc tttccgatgg ctctatatga gttatcctcg tgctgcatct cgtactcatc 983641 aaatccgaac tgaaaaccgc agcacgggca gatttcatga gaatgattgc cttcatgatc 983701 atatggcggt tcagccaatc cttaaacccg cagactgggc aagtatgctt cattttgctt 983761 tcctcccaat aaaataagct gccggacatg ccggcagcta ttcgacagcg aaatatgtgg 983821 tgacatagga aggccgggag aagatcgacg ttgtgtcaat tccggcagat gtatcgcgtt 983881 ttttgtgggc ttctttgtaa gaaccggact gctgccagtc ttgaaaggcg ctttccgttt 983941 cccacaaggt cagaatgaca taggtgtcac tgtcaagcgg acggagcact cgaattgctt 984001 caaagccagg ctcgttttcg acttttcccg ctctgttttt aaatctgttt tcaaacagcg 984061 gacgcccttc ctgagtaacg gcaatattgt tcaatactgc aaaaccggga tgtttgatct 984121 ctccgacttg gtcaatgact tcataagcgt gtggtgcctg gaaaacggta tctccgtttg 984181 tttcatgaat taaaatggcg ttttcctgcc cctgcatcaa aaggatattt tctgagggat 984241 gcttctgtac gatcgttttt aaaaaatcgg ctgtcccata tgtaatataa accttcatat 984301 cagccacctc ctgcttgcta gtatatcaaa acaatggtat aagtttctat tggcgagtgc 984361 ttcgaacata attccaaaca atttttccca tactaccttt agaaaggcga ggtgagttca 984421 tgtttaagat aaagaaaaag aaacttttta tacctatcat tattttagtg ttaactgctt 984481 ttctcgcttt aataggatat atttcaatta tttttctcgg ccattatgtc atagatgaaa 984541 aaaagcttat tcttcatgct tcttcaaaaa ttgttgatca aaacggagat gaggttgcaa 984601 gcctgtatac agaaaatcgc gagccggtct cgatcaatga gattcctaag caggtcagag 984661 aagcgtttat cgctgttgag gataaaaggt tctatgagca tcacggcatt gatgcaaaat 984721 ccgtcggaag ggcagtgtac cgcgatatat tagcaggcgg aaaggtggaa ggcggaagca 984781 cgatcaccca gcagcttgcc aaaaatattt ttctgacaca tgacaaaaca tttctaagaa 984841 aaacaaaaga agtgatcatt gcgattaatc ttgaacggga ttacagcaag gacaagctgc 984901 ttgaaatgta tttaaaccag ctttacttcg gacacggggt ttacggcata caagcggcgt 984961 cccactatta ttttaataaa gaagtaaaag atttgactgt atctgaaggc gctgttttgg 985021 ccgctattcc gaaggcgcct tctacgtact ctccaatttt gcaccctgat aaaaataagg 985081 agcggcgtga tacaattcta ggtatgatga atgaccaagg ctatatcagt gcgaaagagg 985141 ctgtcaccgc acagggccgg acgcttggac tgcatgtgaa gaaacagtcg gaaacacctt 985201 ggtttgacag ctacattgac cttgtgatca aagaggcgga agacaagtat tccatttccg 985261 gagagcagct tcttcaaggc ggatacacga tcaaggtgcc gctcgattcg aagctgcaga 985321 agacggctta ccaggtgatg aaagagggaa gctattatcc cggaacagat cagaatgccg 985381 agggaagcgc ggtctttatt aataacaaga caggcggtgt agaagcggcc atcggcggaa 985441 gggattacac atccaaagga tataaccgtg tcacagctgt ccgccagccg ggttccacat 985501 ttaagccgct tgctgtatac ggaccggcga tgcaggaaaa gaaatttaag ccatattctc 985561 tattgaagga tgagttgcag tcctacggag attatacgcc gaaaaactac gacagccggt 985621 atgagggcga agtcactatg tctgacgcca ttacgtacag caaaaacgcg ccggctgtct 985681 ggacgctgaa tgagatcggc gtcgaaacag ggaaatctta tttgaaagca aacggcattg 985741 atatccctga tgaaggcctt gctcttgctc taggcggctt ggaaaaaggc gtttcaccgc 985801 tccagcttgc cggcgcgttt catacatttg ccgcgaatgg aacgtatact gaacccttct 985861 ttatctcgag cataatagat gaagacggag aaacaatagc cgatcataaa gaagaaggaa 985921 agcgggtatt cagcaagcag acgtcttgga atatgacgag aatgctgcag caggtagtca 985981 aaaagggaac ggccacgtcc ggcacctatc acggcgacct ggcgggaaaa acaggttcaa 986041 catcttatac aggcgtctcc ggcgcgacaa aggacgcctg gtttgcaggc tatacgccga 986101 aaataaccgg ggcagtctgg atgggctatg acaaaacgga tcaaaaccat tatttgaaag 986161 ccgggagctc atacccgacg cggctgttta aggatatttt gacacaggca ggagaaaccg 986221 gtcatgtgtt cacaaagcct aaaaacgtta aagaactgga aagcccgatt gagctgaagc 986281 cggtcaaaac actcacagcc gattacacat ttaaagcagc ggggctcttt actattgaat 986341 taaagtggga cgctcaagag gatgatcggg ccgtatacag aatttatgta aacaaggacg 986401 gcgaggagac gcttcttgat tcggttgaag ggaagggaag ctatgaaatt ccttatgcca 986461 acttattttc gggcgcgtct tataaaattg tgccttataa tacacagaca aaaagagaag 986521 gggaaggaac cgattacgtt cagccaaaat tgttttcctc ttaatggaat tcggcgattt 986581 tttgaacttt gagctacatt tctataccat ttgcctaaaa caaggtatag tgtaataagt 986641 caagaaatac gaacgtatgg ttgccgtatg aaaggtggaa atcagatgag taaacgagaa 986701 acgtttaacg agacgttttt aaaagctgcg cggggagaaa aagcggatca cacgcctgtg 986761 tggtatatga ggcaagcagg gcgctcacag ccggaatacc gcaagctgaa ggaaaagtac 986821 ggattgtttg agatcacaca tcagcccgaa ctttgtgcgt atgtcacaag actgccggtt 986881 gagcaatacg gagtcgatgc tgcaatcctt tataaagata tcatgacgcc gctgccgtca 986941 atcggtgtgg atgttgaaat caaaaacggg atcggtcctg tgattgatca gccaatccgg 987001 tctctggcgg acattgaaaa actcggccag attgatccgg aacaggacgt gccgtacgtg 987061 cttgagacga ttaaactgct tgtcaatgag cagctgaacg tcccgctcat cggtttctca 987121 ggtgcgcctt ttacgcttgc aagctatatg atcgaaggcg gcccgtcgaa aaactacaat 987181 aaaacaaaag ccttcatgta cagcatgcca gatgcatgga atctgctgat gtccaagctt 987241 gccgacatga tcatcgtgta cgtgaaagcg cagattgagg caggcgcaaa agcgattcaa 987301 atctttgatt cgtgggtcgg cgcattgaat caggcagatt acagaacata catcaaaccc 987361 gtgatgaacc ggatcttttc agagctcgca aaggagaatg tgccgctgat catgtttggc 987421 gttggcgcaa gccatcttgc aggtgattgg catgaccttc ctctcgatgt tgtcgggctt 987481 gactggagac tcggcattga tgaagccaga tcaaaaggaa ttactaaaac agtgcagggc 987541 aacctggacc cgtccatttt gcttgcgcca tgggaagtca ttgagcagaa aacgaaggaa 987601 atacttgatc agggtatgga gtcagacggc ttcattttca atcttggcca tggggtattt 987661 cctgatgtca gtcccgaggt tttgaaaaaa ctgacagcat ttgtccatga atattcacaa 987721 aacaaaaaaa tgggtcaata ttcctaagca tatcttttgg tatcttaatg atatcctgtc 987781 aaaatgtttg tatcagatca ttaaagaggg tgtaaacagt gagtagaaag aaaatggggc 987841 ttctcgtgat ggcgtacggc acgccttata aggaagaaga tattgaacgt tattatacac 987901 atatcagaag aggcagaaag cctgaacctg aaatgcttca agatttgaaa gacagatacg 987961 aagcgattgg cggcatttca ccgcttgccc aaatcacaga acagcaggcg cataatctgg 988021 aacagcactt gaatgaaatt caggatgaga ttacgtttaa agcgtatatc ggactgaagc 988081 atatcgagcc gtttattgaa gacgccgtag cagagatgca taaggatggc attacagaag 988141 cagtcagcat cgtgctggcg ccgcatttct ccacgttcag cgttcagtcc tacaacaaac 988201 gcgccaaaga agaggctgaa aaactcggcg gcttaacgat tacgtcagtt gaaagctggt 988261 acgatgaacc gaagttcgtg acatattggg ttgaccgagt gaaggaaaca tatgcgtcaa 988321 tgcctgagga tgaaagagaa aacgcaatgc tcatcgtatc cgcacacagc ctgccggaaa 988381 aaatcaaaga atttggagac ccgtacccgg accagcttca tgaatcggcg aaattaattg 988441 ctgaaggcgc aggcgtttcc gaatatgctg tcggctggca aagtgaaggg aacacgcctg 988501 atccttggct cggacccgat gttcaggatt taacacgtga tttattcgaa caaaaaggct 988561 atcaagcatt tgtatatgtt cctgttgggt ttgtcgcgga tcacttagaa gtgctttatg 988621 ataatgatta tgaatgcaaa gtggttactg acgatatcgg cgcaagctat taccggccgg 988681 aaatgccaaa tgccaagcct gaatttattg atgctttggc aacagtcgta ttaaaaaaat 988741 taggacgtta aagaaggcga tgaacatgag tgacggcaaa aaacatgtag tcatcatcgg 988801 cggcggcatt accggtttag ccgccgcctt ctatatggaa aaagaaatca aagaaaagaa 988861 tctgccgctt gagctgacac ttgttgaggc aagtccgaga gtcggcggga aaatccagac 988921 tgtcaagaaa gacggctata tcatcgaaag agggccagac tcatttctgg aacgaaagaa 988981 aagcgccccg cagcttgtta aagacttagg tcttgagcat ttgcttgtca acaatgcgac 989041 cgggcaatcc tatgtgcttg taaaccgcac cctgcatcca atgccgaagg gcgctgtaat 989101 ggggataccg acaaaaattg cgccgtttgt ttctacgggt ctgttttcct tgtccgggaa 989161 ggcgagagct gctatggatt tcatcctgcc tgcaagcaaa acaaaggatg atcagtcatt 989221 gggagaattc ttccgcagac gtgtcggaga tgaagtggtc gagaacttaa tcgagccgct 989281 actatcaggg atctacgcag gcgacattga caagctcagc ctgatgtcga catttccgca 989341 attttatcag acggaacaaa agcatagaag cctgattctc ggcatgaaaa aaacaaggcc 989401 tcaaggctca ggccagcagc tgacggcaaa aaaacaaggg cagttccaaa ctctgtcaac 989461 cggtttgcag acccttgtag aagagatcga aaagcagtta aagctgacga aggtgtataa 989521 aggcacaaaa gtgaccaaac ttagccatag cggctcttgc tattcgctcg aactggataa 989581 cggcgtcaca cttgatgctg attcagtaat tgtgactgct ccgcataaag cggctgcggg 989641 aatgctttct gagcttcctg ccatttctca tttgaaaaat atgcactcca catccgtggc 989701 aaacgtcgct ttaggtttcc ctgaaggctc cgtccaaatg gagcatgagg gcacgggttt 989761 tgtcatttca agaaacagtg actttgcgat cacagcctgt acgtggacga ataaaaaatg 989821 gccgcacgca gcgccggaag gcaaaacgct gcttcgggca tatgtcggaa aagccggaga 989881 cgaatccatt gtcgatctat cagataatga cattatcaac attgtgttag aagacttaaa 989941 gaaagtcatg aacataaacg gcgagccgga aatgacatgt gtaacccgat ggcatgaaag 990001 catgccgcag taccatgtcg gccataagca gcgtatcaag gagctgcgtg aagcacttgc 990061 atctgcgtat ccgggtgttt atatgacagg cgcttctttc gaaggtgtcg gcattcccga 990121 ctgcattgat caaggaaaag ctgccgtgtc tgacgcgctt acctatttat tcagctaaaa 990181 cctccgcttt atcgcggagg tttttttgat gtgcaatggc aatattgtgt aaaaaatgat 990241 tgaattgaac agcaggttat gatacatttg catatgtact taatgactaa aatgttcaaa 990301 cggtcagttt cgaggtgaat acaatgtcaa tagatcgaaa aaagctcatt ttggaggcgg 990361 ctacaaagtc tttcacgcag ttcgggtata aagcgacgac aatggatctt gtcgcaaaac 990421 ttgcgaacgt ggggaaggga accatttata cttttttcaa aaacaaagaa gagctgtttg 990481 acgagatttt cactacttta ttaaaggaaa tgaagcaaaa agcggatgaa gcgatggagc 990541 cgagccttcc gttccatgaa aatgtgcaca gagcgctgtt tgccattctg gagttcagga 990601 aaacacatca gctgacgatt aaaattttcc aagagaatgc cgagattggt acaatggcag 990661 ttcaggaagt gatccagaaa atggagcgat ccatcctgtc ttatatcaaa agcaagattg 990721 aagacgggat caaaagcggc gcaatcaagc cgtgcgaccc tgagctgaca gcctttgtga 990781 tgctgaagct ttatatcgcg ctcatttttg actgggaaaa acaacacccc ccgcttgata 990841 aagagacaat tgcgggactg cttgaattgt atgttgtcaa aggattgtca gcgaactaga 990901 taatcctttc tctttgcaag aaaatgacca ttttttatga tgagtcagtt ttagaatgga 990961 ggcatcagga tgaacacaat acgaagtcag tggaaagaca tcgtaacaag taaaaaatta 991021 ttgattccca tcatcgccat tttgtttgtc ccgcttattt acagcggcgt attcttaaag 991081 gcttattggg acccgtacgg cacagttgac cagctgcctg tcgttgtcgt caaccaagac 991141 aagggagcaa cgtatgaagg agaaaaactt caaatcggtg atgatctggt caaagaatta 991201 aaggataata acaactttga ttggcatttt tccaatgatc tcgaccaatc gttaaaggac 991261 ttattgaatc aaaaatatta tttagttgtc gagattcctg aggatttttc taagaatgcc 991321 agcactgtat tagacaaaaa tccgaaaaaa ttggatctga aataccatac aaatgcaggt 991381 tctaactatg taggggcaac gatcggcgaa aaagcgattg ataaactgaa agcctctgtt 991441 tcaaaagaag tgaccgagca atatacgaaa gttatttttg ataactttaa agatatcgca 991501 aaaggtttga gcgacgcgag cagcggcgcg aaaaaaattg atgacggcac aaaggatgcg 991561 aaaaacggaa gcgcccagct gaaagaaaat ctggcgaagc tgaaggaaag caccgctacc 991621 atcagtgaca aaacagcgca gcttgcagat ggagcggctc aggtgacgag cggcatccaa 991681 tcacttgaca gctcgctcgg taaattccag gacagcagca accagattta tgataaatct 991741 agtcagcttg cagcaggatc aggcgagctg acaagcaaga tgaatgaact tcttgccgga 991801 cttcaaaatg tgcagaaggg tacgcctaat cttactaacg ggttggatca gctcaacagt 991861 aaagtccaag aaggttctga gaaagcggca aaagcggaaa agatcattaa tgcgctcgat 991921 ttaacgaagc ttgaaactgc tgtaaacaat ctggaaaagt cagaaactgc gatgaaggaa 991981 ttcaaaaaac agctgactga ctttgaaaac agtttgaaaa accgtgatca ggcatttaaa 992041 aatgtcatca attcgagtga cttcttaaca gcggagcaaa aaagccagct gattaattct 992101 gttgagaaaa agcttccgca agttgatgcg cctgattttg atcaaatatt aagccagcta 992161 cctacagctg atcagctgcc tgacatcgca acgataaaaa gctctcttga agacgtgaaa 992221 gcgcaggtgg cgcaggtgaa agccatgccg gaagctacat ctaagcttta taacggcgca 992281 aaaacaatcc aagatgcgat tgacagatta actgagggag ctgataagat atacaacggt 992341 tctcagaagc tgacagatgg ccaaactaaa ctgacagcgg gcatcggtga atataataag 992401 cagttcgcaa aagcaaaagc gggctcagag caattggtga caggaagcag ccaagtatcc 992461 ggcggattgt ttaagctgtt agacgggtct aaacaggtcc aaagcggatc atcaaaactt 992521 gcagacggat ctgcatcact tgatacaggt ttaggcaagc tattggacgg cacaggagag 992581 ctgtctagta agctgaagga tgcggctgac caaacaggag atatcgatgc tgatgatcaa 992641 acatacggca tgtttgcgga tccggttaaa accaaagatg atgccattca ttccgttcct 992701 aactatggaa cagggctgac accttatatc ctgtcaatgg gcttgtatgt cggcggcatc 992761 atgctgacgg ttgtcttccc gctgaaggaa gcgtcaggac gtccgagaaa cggttttgag 992821 tggttcttca gcaaattcaa tgtcatgatg cttgtaggaa tcattcaatc attgattgtg 992881 gcgacggttc ttctattggg aattggtctt gaggtagaga gcacgtggag attttacgtg 992941 tttacgatca ttacgagtct cgctttcctg gcgataattc aatttttggc tacaacgatg 993001 ggcaacccgg ggcgatttat cgcagtcatt attttagtgc tgcagctggg agcgagcgga 993061 ggaaccttcc cgctggaatt gcttccgaat ttctatcagg tcatccacgg cgcattgccg 993121 atgacctaca gcattaacgg attcagagca gtcatttcaa acggtgactt tggctacatg 993181 tggcagatgg ccggcgtctt aatcggcatt gccctcgtca tgattgcact aagcattact 993241 tactttacaa tgttaagccg gaaggaagaa acatcagaag aacagccggc ttcataaaga 993301 aaaagaactt gtttccttgg aaacaagttc tttttttgtt acatccccca tttaataagc 993361 aatcctgtat aggttaatcc gccgccaaac ccgaaaagca aaacgatttg atcttttttc 993421 agcttcccgg ctttcactgc gagatcgagc gccaaaacaa ttgaaaccga agacgtgttt 993481 ccgtagtgct caacactagt gagcgttttt tcaatcggga acggtgtttt ttcacaaatt 993541 gactcgatca tgcgcaagtt ggcgctgtga ggaacaaacc aatcgagatc atcggagctg 993601 agtcctgctt tatgtaaaag ccgttcaaat tcgccaggga cggttcttgc ggcccattta 993661 tatacctcgc gtccgttttg caccattttt ccggaaccga caagctgcac accgtttatt 993721 tcatttcgca gtccggcacg atacaaaata tcgccgccgt tcccgcttgt tccttgtaca 993781 gacgcaagaa atcccggcgt ctcttcatct cgttctacta acagcgcacc cgcggcatcg 993841 ccgaacagta cgcatgtcgt tcgatcggta taatcggtta cctttgataa cgtctctccg 993901 gcgatgacga gaattttttg atgaaggcca gatgtgatca atccatttgc caaatggagg 993961 ccgtatgtca gcccggcgca tgtcgcatta atatccagcg cgccggtgct ttcccagccg 994021 aaatattcct gtacgcggca tgccgtactc ggaaaggcgt aatcggatgt ggttgtggca 994081 acgaggatca tatcgacatc atcaagcgtt cctttataac ggctcttgag attcttcacc 994141 gcttctatgc ataaatcaga ggtaaattga tgttcatccg caatccggcg ttctctcatt 994201 cctgtgcgct gaacgatcca ttcatcagag gtatcaacga tcttttctaa atctgcattg 994261 gttaaacgtc tgctcggcgc ataggtgccg atagctgtaa tttttgcttt tgacatatga 994321 atcactcctt atggtcagat tataacacta gatattagta tctggtacta aaaagaaggt 994381 ttttttacaa aaaaagagaa gtgtagatag gaatctatga aaaagaaaaa ggaggctgaa 994441 aaatggtcag tcaagaagca gtagtctttt tggcattatc cggggctatt gcgtttctgt 994501 tgccaatcgg gctgattgta tggtttaagc gaaagtatgg tgcctcgctt aaagtgtttt 994561 ttattggcgc tctcacgttt tttgtcttcg ctcagctgct ggaaggcggc gttcatgttt 994621 atgtactgca agtgaatgaa atgacgaaag aagcgatgca gcatccatta tggtatggca 994681 tttacggctg cttgatggcc ggcatttttg aggagtgcgg aaggtatttg atgatgcgat 994741 tttttatgaa gcgccatcat acttgggcag atggtctggc tttcggggca ggccatggcg 994801 ggcttgaagc catcctgatt acaggcttgt cctctatctc acttattgta tacgcatttg 994861 caatcaatag cgggacgttt gaacagcttt tggtcaatgg cgacgtcaaa caggcgcttt 994921 tgccgataca ggagcagctg ctgcatactc cttcgtatga atggatgctg ggcggaatag 994981 aaagaatcag tgccattgcc gtccagattg gtctgtctct gcttgttttg tacgcggtta 995041 aaaaccgccg gccgctgttt ttgctgtatt ctattctttt acatgcactg tttaatgtcc 995101 cggcggtttt atatcaaaga ggaatcatag agcatgctgc agctgttgaa atcattgttg 995161 ctcttatagc ggctttatca gtttattgga ttgtaaaagc aaaaagggtg tttcaataaa 995221 aggtccaagc agcagcaatg cccgcttgga aaaatgtgaa tggaaatatt cattaagcat 995281 gggtcatcag aatatttctg attcagtctt tagcaatgac agcaagaatg tctgtgtttt 995341 ttacaagaga aacaatggtg tttctttttc ttcttctcgc aagggtcatg gcattctttc 995401 tttttcttgc aatggtcgtg gaaatcttta tcgaaccact cgtcaaagaa ccaaaaatca 995461 tcgaaccaat cgtgacaacg acatttctgt tcatgtgaat gacgacagca catagaaatc 995521 cctcctcttc ccatgctctc tacagcatat gagagattga taggaaaaga ttggacgggt 995581 ccctcgggaa aagagtatat tttaagtaga aaataaaagg aggaatgccc tatgacgtcc 995641 gtacgtaaaa cgatggagct cattaaagaa cttgtatcga tcccaagccc gacaggaaat 995701 acatatgagg tgatcaatta tattgaaagc cttttaaaag aatggaaggt agaaacggtt 995761 cggaaccaca agggcggctt aattgcaacg cttccaggac gcgacacatc ccggcatcgc 995821 atgctgacag cgcacgttga caccctcggc gctatggtga aggaaattaa agcggacggc 995881 cggctgaaaa tcgacttaat cggcgggttc cgctacaact cgattgaggg ggagtattgc 995941 caaattgaaa ccgcctcggg aaaaatgtac acaggcacaa tcttaatgca tcaaacgtct 996001 gtgcacgtat acaaagacgc gggaaaggct gagcggaatc aagagaatat ggagatccgc 996061 ctagatgaac ctgttcactg ccggaaagat acggaggagc ttggcattgg cgtcggagac 996121 tttgtgtcgt ttgatccacg tgtcgagatc acatcaagcg gatttattaa atcgcgccat 996181 ttggatgaca aagcaagcgt cgccttattg ctccgcttaa ttcatgaaat tcaaacagaa 996241 gacattgagc tgccgtatac aacccatttt cttatttcca ataatgaaga aatcggttac 996301 ggcgggaatt cgaatattcc tcctgaaaca gttgaatatt tggcggttga tatgggcgct 996361 atcggtgacg ggcaggcgac ggatgaatat tcagtatcaa tctgtgtgaa ggatgcgagc 996421 gggccgtatc attatcagct cagaaagcat ttagttcaat tagccgagaa gcatcatatt 996481 gactataagc ttgatatata tccgtactac gggtctgatg cgtcagcagc gatcaaatcc 996541 gggcatgata ttgtgcatgg cctcataggg ccgggaattg acgcttccca tgcatttgaa 996601 cgcacccata aatcatctct tcgccatacc gctaagcttc tgtattacta tgtacagtca 996661 ccaatggtat aagggggagg accaatgaag atttataagc tgaaaagcac attcggttgg 996721 gaaggtgatg acgggttggg agaacagctg attcagcaga tccttgccgg agaaaaaagc 996781 gccacgtgcg cgccgaaatc attgtattca aaagatgaat tgagggacgt ttatcaaaca 996841 gcgggtcagc ttgttaccgt ttatgataaa catgacaatc caagatgcaa tataaaagta 996901 acagatgtct ttgaaaccac ctttggtgcg cctgatatga ggttagtcaa aggagagggc 996961 aatggagacc gaattgagga gtttcaagag gatcatcgga tggcatgggc ggaactgatc 997021 aaaagcggtg aactggagct gaatgaggat actgttttga ttacagagtt gtttgtgctt 997081 gttaaagatt aaaaaagcct gcggggcaag aaccccgcag gcttttcatt aaccagaaat 997141 ggttgcgttt tgttctgttt tcgattggga cataacagtt tctgctttcg caggattaaa 997201 catgccttcc catttagaca tcacaacggc agcaagcgcg ttaccagtca ggttgacaac 997261 tgtacgtgcc atatccatga tgcggtctac gccggcaata aaggcaagtc cttcagccgg 997321 aacgccgatg gtgccaagcg ttgcaagcaa gacaacaaaa gaagtaccag gtacggcagc 997381 catccctttg gatgtcacca ttaagacgag cacaagcgta atttggtgcc aaatcgtcaa 997441 atcaatgcca tatacctgtg ctaaaaagag tgcggcaata gattgataga gaacggaacc 997501 gtctaagtta aacgtgtaac cgatcggaat gacaaatgaa acaatgcctt ttggacatcc 997561 gattttctcc attttttcca tgatacgcgg aagaaccgtt tcagagctgg acgtactgaa 997621 cgccagtaag atttcgtcct tcatgtaagc aaggaacttg aagatgctga tgccggcaat 997681 ttttgcgaca atcccgaaaa taacaattaa gaagaaagca agcgcgacat aaaccaatcc 997741 gacgagcttt ccgagagaga taagagaacc gagtccgaat ttagacacag tcactccgat 997801 aagagcgaaa acgccgaatg gcgccacttt catcacaagg tttacaacgt ggaacatggc 997861 atgggataca ccttcaaaaa aggctaatac aggcttgcct ctttcaccga tcgcggaaat 997921 acccaatgca aatagtactg taaagcagat gatggctaga agatcccctt cgaccaatga 997981 ctggaagaag tttgtcggca caatatggag gaacgtttcc gccactgatt tattactttg 998041 ttctttttca gtttcaacat attgactgat gtccgatttt tgagcttcgt gtatattaac 998101 tcctgtaccc ggatggaaga tgtttgcaag ggctagtccg agaataatgg caaaagtcgt 998161 gatgatctcg aagtacagaa tcgttctgaa gcctaattta ccgacttgct ttccatttcc 998221 tgcaccggct acaccgatga ttaagctgga gacaacaata ggaatcacta tcattttgat 998281 taagcgtaaa aagagatccc cgattggctg caggtaagta ggcaatgctg ggttgccata 998341 ccaaatgacg ccaacaatga cacctagaat aagtccaacg aatatttgtg tggctaatcc 998401 aaacttaatt cttttcatag attacctccc aaaaaacaaa gtatcaacat atatcatgaa 998461 tagacatata tttaatctca ctattagatc aaattataat agataagaaa tcaattcgtc 998521 tatagtaaat tatatttcga aaataaagaa tattcaatga cattatgata atcaccagaa 998581 ttatctaaaa acaggtgagc tttgacctaa cctgactatt atttcaaaat taagagatat 998641 gtgaaaaaat aagaaaatcc cacgcgtaag gcgcgggatt ttcgctcatt acaaatcgtt 998701 tacttttata cagtcattgc agatattacc ataacactca tgctgctctt ctatcttttt 998761 tccgcattcc gcacactttt tcgaaggcag gtttctaaaa aattctgtga ttttccccag 998821 cataaccaat ccctctttcc cctttgtagt gatttcattg taatataaca gattacaaaa 998881 atcaataact gttttgatac aatgtttaaa acatgctttt ttcaagaaaa atgggtatat 998941 tgaaggagga ccaatttttt tgaaaagata ggaggacatt atgaaagtta cagttatcgg 999001 atgctatggc ggttttccgg ccgcaaatga agcgacgtca ggctatttgt ttcagtcagg 999061 tgattactct ctgcttgttg attgcggcag tgccgtattg tctaagctgt tcggatatgt 999121 gccggcggaa aagctggatg cggtcgttct gtctcattat caccatgacc atatcgctga 999181 tatcggaccg ctgcaatttg ccaagcaagt cggttcgttt ctcggcaaag gagagcatac 999241 gcttccgatt tacggacatg atgctgatat agaacagttt caaaagctta catataaaac 999301 acatacaaaa gggatcgcct atcagccgga tcagccgctg actgccggtc cgtttacgat 999361 caccttttta aaaacgattc acccggtgac gtgctatgcc atgcggatta ctgacggcag 999421 ccacactgtc gtttatactg ctgattccag ctatcaggat tcatttatac cgttttcgaa 999481 agatgctgat ttattgatct cagaatgcaa tttttatgcc gatcaagacg gaacaagtgc 999541 aggccatatg aacagcctgg aagctgggcg cattgcaaaa gaagccggag cgggagaact 999601 gctgctgaca catttgccgc attttggcgt gcatgacaac cttcgcaaag aagcgaaaac 999661 cgtttttaac ggagaagtga atattgcgaa atcaggtttt gtgtgggaag gataaaggag 999721 gagcaccatg ttatttatag acaatcaaaa tatcaatgat ccgcggatca atcttgctat 999781 cgaggagtac tgtgtaaagc atttagaccc tgaacagcaa tatttgctct tttatgtgaa 999841 tcaaccgtct attatcattg ggaaaaacca aaatacaata gaagaaatca atacaaaata 999901 tgttgaggaa aacgggatta tcgtcgtccg ccgtttatca ggcgggggcg ctgtgtacca 999961 tgatctgggg aacttgaact tcagctttat taccaaggat gacggggaca gctttcataa 1000021 ctttaaaaaa ttcactgagc cagtgattca ggcgttacat cagcttgggg ttgaagccga 1000081 attaagcggc cggaacgaca ttgtagtaga tggccggaaa atatccggaa acgctcagtt 1000141 tgcaacgaaa ggccgtattt tcagccacgg caccctcatg tttgattcag ccattgatca 1000201 tgttgtatca gcattaaagg tgaaaaagga taaaattgaa tcaaaaggca tcaaatcgat 1000261 cagaagccga gtggcaaaca tcagtgagtt tctcgatgat aaaatgacca ccgaagaatt 1000321 ccgcagccat ttgcttcgcc atatttttaa cacaaacgac gttggaaacg tgccggagta 1000381 taagctgacg gaaaaagatt gggagaccat tcatcaaatt tcgaaagagc gctatcagaa 1000441 ttgggattgg aactacggcc gctcaccaaa atttaacctt aatcattcga agcgttatcc 1000501 ggttggatcg atcgatttgc acctggaagt caagaaaggc aaaatcgagg actgcaaaat 1000561 cttcggagat ttcttcggtg tcggtgatgt atctgaaatt gaaaacctgc tggtcggaaa 1000621 acaatacgaa cgcagcgtca tcgctgatgt gctcgaaggt gtgaatctca agcattactt 1000681 tgggaacatt acgaaagagg atttccttga tctgatttac taaggcaaaa cacatcgttt 1000741 gaaagagcgg ttgtgttttt gaaataatgg aggcaggagg gattcacatg aaagtgtttt 1000801 taatcggagc gaacggacaa atcgggcaaa gactcgtctc tttattccaa gataatcctg 1000861 atcattccat cagagcgatg gtcagaaaag aagaacagaa agcgtctctt gaagctgccg 1000921 gtgcagaagc tgtgcttgcg aatctggagg gcagcccgga agaaatcgcc gctgcggcaa 1000981 aaggttgtga cgcgatcatt ttcacagccg gttccggcgg cagcacaggc tatgataaaa 1001041 cgctgctggt ggatcttgat ggagcggcaa aagccattga agctgcggcc attgccggaa 1001101 tcaaacggtt tattatggtc agcgccctgc aagcccataa ccgtgaaaat tggaatgagg 1001161 cactcaagcc ttattatgtg gccaagcatt atgctgataa aattctggaa gcgagcggtt 1001221 taacctatac gattatccgt ccgggaggcc ttcgcaatga gcctggaacg ggaactgttt 1001281 cagcagcgaa ggatctggag cggggattta tttcccgtga tgacgttgca aaaacggtca 1001341 ttgcctcttt agatgagaag aatacggaaa atcgggcctt tgatctgaca gaaggagata 1001401 cgccgattgc cgaagcattg aagaaactat gacagtactg acactcaggg ctttttgctc 1001461 ttgagtgttt ttttctgttt ctctataatg gagaagaaag cttggcttca ataatgaatg 1001521 actattcatt cacttaaggg gtgggagaat gaatcttgtt tcaaaattgg aagaaacagc 1001581 atctgagaag cccgacagca tcgcatgcag gtttaaagat cacatgatga cgtatcaaga 1001641 gctgaatgaa tatattcagc gatttgcgga cggccttcag gaagccggta tggagaaagg 1001701 ggaccattta gctttgctgc ttggcaattc gcctgatttt atcatcgcgt tttttggcgc 1001761 tttaaaagct gggatcgtag ttgttcccat caatccgttg tacacgccga cagaaattgg 1001821 ttatatgctg acaaatggcg atgtaaaggc aatcgtgggc gttagccagc ttttgccgct 1001881 ttatgagagc atgcatgaat cgctgccaaa ggttgagctc gtcattttat gccagacggg 1001941 ggaggccgag ccggaagctg cggacccaga ggtcaggatg aaaatgacaa cgtttgcaaa 1002001 aatattgcgg ccgacatctg ccgctaaaca aaaccaagaa cctgtacctg atgataccgc 1002061 ggttatttta tatacgtcag gaacgactgg aaaaccgaaa ggcgcgatgc tgacacatca 1002121 gaatttgtac agcaatgcca acgatgtcgc aggctatttg ggaatggatg agagggacaa 1002181 tgtggtctgc gctcttccca tgtttcacgt gttttgttta accgtctgta tgaatgcacc 1002241 gctgatgagc ggcgcaactg tattgattga gcctcaattc agtccggcat ctgtttttaa 1002301 gcttgttaag cagcagcagg cgaccatttt tgccggtgtg cctacaatgt ataactactt 1002361 gtttcagcat gaaaacggaa agaaagatga tttttcttcg atccggctgt gcatttcggg 1002421 aggcgcgtcc atgccagtcg cgttgctgac ggcgtttgaa gaaaaattcg gtgttaccat 1002481 tttggaaggc tacgggctct cggaagcatc acccgtcacg tgctttaacc cgtttgacag 1002541 gggcagaaag ccgggctcca tcgggacaag tatcttacat gtcgaaaaca aggtcgtaga 1002601 tccgctcgga cgcgagctgc ccgctcacca ggtcggcgaa ttgatcgtga aaggccccaa 1002661 tgtgatgaag ggctattata aaatgccgat ggaaacagag catgcattaa aagacgggtg 1002721 gctttatacg ggggacttgg caagacggga tgaggacggc tatttttaca ttgttgaccg 1002781 gaaaaaagac atgatcattg taggaggata caatgtgtat ccgcgggagg tggaggaggt 1002841 gctgtacagc catccggacg tcaaggaggc ggttgtcatc ggcgtgccgg acccccaaag 1002901 cggggaagcg gtaaagggat atgtggtgcc gaaacgctct ggggtaacag aggaggacat 1002961 catgcagcac tgcgaaaagc atctggcaaa atacaagcgg cctgccgcca ttacgtttct 1003021 tgacgatatt ccgaaaaatg cgacggggaa aatgctcaga cgggcactga gagatatttt 1003081 gccccaataa aatgaaaaag cgaagcggtt agcttcgctt tttcattttc aatcctttgc 1003141 ttctttttta ataatattta gcagcgcctt tgtatcattt ttgcttaatt tgtagtatgt 1003201 gccatccttc aaaaaaacgg cttgctggct gccgtcaatc catagtctga atgagtcata 1003261 ccggtcttta tgaaacttga ttgtcccttc gtaatcaggg gctgatgttt tttctgtctt 1003321 cacctgtttt ccctgattca taatatccag catatctttg acgtgctgtc ttttttcaat 1003381 ctcgatatct tcctggccgc ttgaagacag tgtgatcaaa tccgcgtcta ccgattgata 1003441 cacatcgcct gatcggctgt aaagataaaa aaatgcgata aacacaagac cgattaccac 1003501 gatggctgcc actatttttt tcatttgcat cactccaaac attgttagtt ttcccagcga 1003561 tcggggtttc catgcttaaa agggtggaaa agtgcggaac acagcttggt tctaagaatt 1003621 tgaatttatg attacaatag aagtaacggg ttgatgtgag gagtgaggcg ttatgcgcaa 1003681 gtggattgcg gcagcaggac ttgcttacgt gctgtacggg ctgttttttt attggtattt 1003741 tttcctgtcg ggtgattccg caataccgga agccgtgaaa gggacgcagg ctgatccggc 1003801 ttctttcatg aagccgtctg agttggcagt ggccgagcag tattcgaatg tcaagaattt 1003861 tttatttttt atcggggtac cacttgattg gtttctgttt tttgttctgc ttgtcagcgg 1003921 tgtttcaaag aaaatcaaga aatggatcga agcggccgtg ccttttcggt ttttgcagac 1003981 cgttggtttt gtgtttgtgc tttcgctgat tacaacattg gtgacgctgc ctttagattg 1004041 gataggctat caagtatcgc ttgactataa catttccaca cagacaacgg ccagctgggc 1004101 taaggatcag gttatcagct tttggatcag ctttccaatc tttacgcttt gcgttctcgt 1004161 tttttattgg ctgatcaaaa ggcatgaaaa aaaatggtgg ttatacgcct ggctgttaac 1004221 agtgccgttt tcgctgtttc tgttttttat tcagccggtc attatcgatc ctttatacaa 1004281 tgatttttat ccgctgaaaa acaaagagct tgaaagcaaa attttagagc tggcagatga 1004341 agccaatatt ccggctgacc atgtatatga agtgaacatg tcagaaaaaa caaatgcgct 1004401 gaatgcctat gttacaggaa ttggggccaa taaacggatt gtattgtggg atacgacgct 1004461 gaacaaactt gacgattcag aaattctgtt tattatgggc cacgaaatgg gccattatgt 1004521 catgaagcac gtttacatcg gtctggctgg ctatttgctc gtgtcgctcg ccggatttta 1004581 tgtcattgat aagctttaca agcggacggt tcgcctaacc cgcagcatgt ttcatttaga 1004641 agggcggcat gatcttgcgg cacttccgct gttattgctt ttgttttctg ttttgagctt 1004701 tgcggttacg cctttttcta atgctgtctc gcgttatcag gagaataagg ctgaccagta 1004761 tgggatcgag ttgacagaga acagagaagc cgctgttaaa acgtttcagg atttggccgt 1004821 gacggggctg agccaggttg atcctccggt gcttgtgaag attttcagag gcagccatcc 1004881 gtcgatcatg gaacggattc aacatgcgga gaaagaagag aatgcgccgg aacatcagga 1004941 tgctgacaaa taaaaagaag caggtatgga ggaacctgct tctttttact attattgtgc 1005001 agctgcttgt acgttgatta acccttttcc atagtagaaa gagtttccaa gatatgttgc 1005061 agtgctttct aaacgatcac ggacttgcgc gtttgtccaa gtcgggtgct tagaaagaat 1005121 taacgctgct gctccggcaa cgtgaggagt cgccatggac gttccgttat aagcgccgta 1005181 agtgcctcca ggaagtgtgc tttggatgga cacgccagga gccatcacat caagctcaga 1005241 acctgcgctg gagaatgaag ctctttggtt gctgctgttt accgcaccta ctgcaatagt 1005301 agaaggatat tttgcagggt agccgactgt gcttgtgctt ccggatgaac cttcgtttcc 1005361 ggctgcggca gcaacgacga taccgctgga aacggctttg tcaacgactg ttttcagcgc 1005421 tgtagaacca gtaggtccgc caaggctcat gttgataaca tccatattgt tggaaatggc 1005481 ccactcaatg ccgttaataa tccagctata ttggccgctt cctgttgaat caagcacttt 1005541 tactgcatat aatgatgcgc ttggcgctac gcccagaaca ccgattgagt tattaagagc 1005601 ggcaatcgta ccggctacat gcgtaccgtg agaactgccg tcctggtatg ggtttgtttc 1005661 agaaggtacg aagcttgctc cgcctctgac gtttaagtca ggatgagaag agtcaattcc 1005721 gctgtcgata acagctactt ttacgttaga gcctgtgtag ccttgagagt gaagagccgg 1005781 cgctttaatt tgagaaatgc cataaggaac agattgcgca tattcatgtg caatatgatc 1005841 ttcttccaca tatgcaacgc tcggatcttt tttcaattct tttacagctt tttcatccaa 1005901 tgttgctgcg gccgcgttaa catacttaaa ttgcttttga acctttccgc ctttttcaga 1005961 aataacatcc tttttcttgg cggaactcat ggcactcatt gtctgtttaa atccgacaat 1006021 gtatttcttt tctgtactgc tttttccggc agcctgcgca gacatgttgc tgaacgccat 1006081 cgtaaagatt aacgttaacg caaacaacaa gctgatccac aattttttgc ttctcactct 1006141 ttaccctctc cttttaaaaa aattcagagt agacttactt aaaagactat tctgtgaatt 1006201 tattgtaata gatggaataa tattttagta gacccatttt tttgagatga ttttatctct 1006261 atttaggtat atcatctctc gctatttccg tagagactcg aaataactat tttcatacag 1006321 aaaagaacga aaatagacat gagtaaatgt tcattatgct gaaatgtcat gcttttttag 1006381 gttaaatgct cctgagtccc ggcaaattcc tgtcgaaaaa attcgttcaa atgacctgcg 1006441 tgtgcttccg tgagaacaat ggatattatc gtgatatttt ttcaaagcat gatgataaaa 1006501 gtattctgaa aaataaactt tacagaaaag ggatagaatg aaaaaattat tgagagggag 1006561 gaagaaataa gatgaacatt cgccaagcaa agacatcaga tgcggccgcc attgcgccgc 1006621 tgtttaacca atatcgggaa ttttatagac aggcatccga tttgcaaggg gcagaggctt 1006681 ttttgaaagc tcgtttggaa aatcacgagt ctgttatttt gatagcagaa gaaaatggag 1006741 aattcatagg ctttacccag ctctatccaa cgttttcttc tgtgtcaatg aaaaggatat 1006801 acatattaaa tgacttattt gtcgttcctc atgcgcgtac aaagggagcc ggcggccggc 1006861 tgctttctgc cgcaaaggat tatgcagggc aaaacggggc aaaatgttta acacttcaga 1006921 ctgagcacca caaccggaag gcaagaagct tgtatgagca aaacggctat gaagaggata 1006981 ccggatttgt ccattattgt ctcaatgtgc cggcgaagtg aaaatggcgg cttgatgatt 1007041 tggttttttg aacgttcttc ggttacgata taaatgaaaa ggagtgtgcc gaatgtcaac 1007101 gttatttcaa gccttgcagg cagaaaaaaa tgccgatgat gtttcagtcc atgtgaaaac 1007161 catatcaaca gaggatttgc cgaaggatgg tgtcctgatt aaagttgctt attccggcat 1007221 taattacaaa gatggtctgg ccggaaaagc aggaggcaat atcgtcagag agtatccgct 1007281 tattttaggc attgatgctg cgggtacggt cgtctcttcc aatgatccgc gttttgcgga 1007341 gggggatgag gtgatcgcga caagctatga gctcggtgtc tcacgtgatg gcggattaag 1007401 tgaatacgct tcggtgcctg gtgactggct ggtgcctttg ccacagaatc tttcgttaaa 1007461 agaagcgatg gtgtacggaa cggcgggatt tactgcggcg ttatcagtgc atcggcttga 1007521 acagaacggt ctgtctccgg aaaaaggcag cgtgctagtc acaggagcaa ccggcggtgt 1007581 cggcggaatt gcggtatcga tgctgaacaa gcggggttat gatgtggtgg caagtaccgg 1007641 aaaccgggag gcggctgatt atttgaaaca gcttggtgca agcgaagtaa tcagcaggga 1007701 agatgtctat gacggaacgc ttaaggcgct gtccaagcag caatggcagg gagcggttga 1007761 tccagtcggc ggaaaacagc ttgcctcgct tttaagcaaa attcaatacg gcggatctgt 1007821 cgcagtgagc ggcttaaccg gcggaggaga agttccggca accgtgtatc cttttattct 1007881 tcgcggagta agcctgctcg gaatcgattc agtatattgt ccgatggacg tcagagccgc 1007941 tgtttgggag cgcatgtctt ctgatctcaa gcctgatcag ctgctgacca tcgtggacag 1008001 ggaagtatca ttggaagaaa cgccgggtgc gttaaaagat attttgcaaa atcgcattca 1008061 aggaagagtg attgtgaagc tttaacagga tcagcttgca gagaatgtta tttttctgca 1008121 agcttttttg tggacaggat gatcagctgc tgaactgctg tgtcgcgaaa caagattttc 1008181 ctgtaagccg aactttctct tctcatttta aaaataattg gtgataatga ttctcattcc 1008241 gtgttatact actcttggac atcttaacca tagaaactac caacaggaga gactggaaca 1008301 tatgaaaaaa acactgatta ttcttacagt tttacttctt tctgtcttaa cggctgcttg 1008361 ctcgtcttca agcggcaatc aaaacagtaa agaacataaa gtggcggtaa cacatgattt 1008421 agggaagaca aatgtgcctg agcatccgaa gcgggttgtt gttcttgagc taggttttat 1008481 tgatacactg cttgatctcg gcattacgcc tgtcggggtt gccgatgaca acaaagcgaa 1008541 gcagctgatc aacaaggatg tgctgaagaa aattgacggc tacacatctg tcggcactcg 1008601 ctcacagcca agcatggaaa aaatcgcttc attaaaaccc gatttaatta ttgctgacac 1008661 gacccggcat aagaaggtgt acgatcagct gaaaaaaata gcgccgacga ttgcacttaa 1008721 taatttaaat gctgattatc aggatacaat tgacgcttcg cttacgattg caaaagcagt 1008781 cggcaaggag aaggaaatgg agaaaaagct gacggcgcat gaagaaaagc ttagcgagac 1008841 aaagcagaaa atcagcgcga acagccagtc cgtgcttttg atcggaaata caaatgatac 1008901 cattatggcc agggatgaaa acttctttac atcgagactt ttaacacagg tcggctaccg 1008961 atatgcaatc agtacgtcag gcaatagcga ttcaagcaat ggcggcgact ctgtgaatat 1009021 gaaaatgaca ctggagcagc tgctgaaaac agatccggat gtgatcatcc tgatgacagg 1009081 aaaaacagat gacctcgacg ccgacggtaa acgcccgatc gaaaagaatg tcctttggaa 1009141 aaaactgaag gcagtgaaaa acgggcatgt ataccacgtg gatcgtgcgg tgtggtctct 1009201 gcgccgcagt gtagacgggg cgaatgccat tttggacgag cttcaaaaag agatgccggc 1009261 tgctaagaaa taaaagaaaa gacaggcaaa cgcctgtctt tttcttattt gataaagccg 1009321 gataagtggc tgttgatatt atagtctttt atccgccatt tttcttctgc aaattcaatg 1009381 ttgctgaggc aggcgttgac gagacgggtg ctttgaagct ccgggtcacc gccggatatt 1009441 tctgtcagca gggcgtgaat tgccgcaccg tgcgccacga tcagcacctt cttgtttgga 1009501 tacgcctgat tcacttttgc caaaccgccc atcagcctgt cagtgagttc ttctaaggtt 1009561 tccatattcg gatagatgtt atctggatag cgctttgtcc gttcctccag cggcatgccc 1009621 tccgcgtcgc cgtaatcgcg ttccttaaaa tcatccatct cgactatcgg aagatgcaga 1009681 tattcattaa taatttccgc ggttcttttc gctcttttca gcgggctcgt cacaataata 1009741 tcccaagaaa agtcctttac atattctccg gtttctcttg cttggcgttc acctgttgcg 1009801 tttagcggga tatcggtttt gccttggcat ttttgctgca ggttccaatc ggtttctcca 1009861 tgtcttacta aacaaacggc tgtcataaaa tccccttcct gactttattc atatcgctat 1009921 tatactaaat cgaaagcgtg tgtcctatga aaaagcctat gcaagaactt caaataataa 1009981 agccagtccg attccgccgc cgcttccgat ggctgcaaca gcatattgac agtctggccg 1010041 tcttttcgct tcataaaaca atctggttac cagagctgca cctgatgcac cgtacggatg 1010101 gccaagagct aaggcgccgc cgcgcacatt gatttttgaa aagggaatgc cgagttcttg 1010161 cgagcagaca caaattttga cggcaaaggc ttcattgatt tcaaataaat cgatatcatc 1010221 aggtgttaca tcgtgtgtat gtaagagctg acgaatcgcg acaaccggtg ccgcgggcgg 1010281 aaagttgggg tgaatgccgc tgacagcgct gccgataaac cgaagcacag gcttaagtcc 1010341 cagggctgct gctttttctt cttccattac caaaagagcg gctgctccgt ctgctatgcc 1010401 actgctgttg gctgctgtga ctgttccgga gctggtgtcg aaaaccggct ttgcacgggg 1010461 aataatcgct tctattggcc gcgttttcaa aaatgcttcg tccgtctcca attccccgag 1010521 agcaacaact tcttcacggt aaaatccttc atcatgcgcg ttcctgctgc gttgatggct 1010581 gagaagcgcg tactcatcct gcatgcttct gctgatggaa tagcgtgcag ccgtatattc 1010641 tgccgcaatg cccatgtctg gatcgccgat cgcatctgga gaaaagcgag cccgttctga 1010701 aaaaggggat tggctgctgc tttctgagcc gcccgcgata tacatcgtgc cggctcccgc 1010761 ttgaataagg ctgcaggcat agcgcacagc ttcaaggccg gagccgcact gtctgtcaat 1010821 tgtcattccg ggaaccgata aaggcagtcc ggcttgaagg gctgacagtc tggccaggtt 1010881 gccgcctctg ccagtagcgt ttccgagaat gacctcgtca acttgatcct ctagctttcg 1010941 gctgagacag cggatgatgg gagccgccaa atcctccggc aggaagggct tcagcagtcc 1011001 gttttgattt ccaaagatcg ttcgttttgc atcaacaata accgcattca tttatactgt 1011061 acactctctt ccagccattt tttcactctg gaacgggcaa tttttccgct gctcgtttcc 1011121 ggcaagctgt ctgcaaacac ccattttttc ggaattttat aggaggctaa tttctgttta 1011181 caccaggctt tcagtgttct ggcattagcg tttccaagaa tgacagctac agcgatttct 1011241 ccccaatact cgtcgggaat gccaacgaca gccgcgcttt caacctctgg gcaggcgaga 1011301 agcacacgtt caatttcttc tgggaaaata tttaatcctc cgtacacgat catcccgttt 1011361 tctcttcctg atatgtatag aaagccctct tcatcaacgt agcccatatc atctactgtc 1011421 atccattcat ctggtgtgct gccgttcaca tagccggaaa acctcatcgg gcttttgaca 1011481 aatatttttc cgatttctcc tggctggcag cgttctcctc cagcgttgcg gatttcgatc 1011541 cggacattat gaaaagggcg gcccgctgaa tgcggcttcc gtttgctgtc ttccggtgaa 1011601 gaaaacgtca caaaactaag ctctgatgtg ccgtaaaaat cgtacagctt gagatgaggc 1011661 catgcagcgg caagcttctt cttggattct gccggccagt ctgcgccgga tgaaatgatt 1011721 ttgacgggac tgtcgggaaa accctcaatc cttgcgaggg cgtctgtcat cgtcggtacg 1011781 gtatagagaa cactgatgga ttcacggcac agccattcct tcgctttggc aggagaaaac 1011841 tttttcagca aacaaacggt tcctccgaga aacaaagtgc tgacagcccc atataggaag 1011901 tgagaggaca ttaacgctcc gggaatcaga accttatcat ctgatgaaat cgaaaaatct 1011961 gtttctgtac aggtaaagct ctccatccat gagcggtgag atcgcgtaaa ggccttcggt 1012021 tttcctgtcg agcccgacgt aaatcccata taaaaagggt gctccggatc aatggtaggc 1012081 aagggatcag cggctgcctc agaaatatct gccatacagt tatccagcaa tacaacaggt 1012141 gtctggctat ctgtcagttt gtttttgaaa aaggctaaag taaccacaag atccgcattg 1012201 cttatggaca gccgctcctt acattcagcc gggctccagc gtgtgtcgat gggaatggcc 1012261 gtacatccag ccgctgcggc tccggcaaac agctgtaaaa acgcgagact atttgggagc 1012321 aggatcgcca cacgattcgg catgctcggc tgtgaccgca gccaatttgc ggtttgagag 1012381 acaagccgat cccaatcatg gtacgtgatt tgctccgatt cagtctggat cgctacacgg 1012441 ccgggcgatg tttcggcagt agatgaatag gtatgagtaa ttgtcatgta ttgtcatcct 1012501 ccttttgtaa acatcgtatc agaaagagac aaggcttgag tgatttttat cgccagaaat 1012561 gcagatacag ccgcttttat caaatcacca ggcacatatg caaggctcat gaaggcggcc 1012621 tgtgacaaat caatatgcat gataaaagct tgtaccggta taccaagcag ataaataaag 1012681 atgatgccga atacgatatg agtgaaaaag agacgcaata ctgtcacctt ccgcagcctg 1012741 ttagcggcta aactgatcag ccatgaagcg aggggataag caatcaaaaa gcctgcgctc 1012801 ggtccgaaaa acacaccaaa accgcctcgt ccgccgggca acagcggcgc tccgaaggcg 1012861 acgagcagca aaaagacaag ctggcttaag aaagcagact ttggcctgag aatgctgcct 1012921 gccaacatga caccaagcgt ttgcaatgta atcggaacgg gtgtaaagga taagaagaga 1012981 gggggcataa agccgagcac tgccatcagc gcggtgaaaa tcgcaatatg catcatgtcg 1013041 attaatttca gcatgtgaaa tcctccaaaa agtaatcaaa tatggttata caataaatgc 1013101 aggtaattat tatgtcaact gatttttaat ttaagtttac ataatgaacg caaaaaaacc 1013161 ggccgtatgg cagaccggtt tttgatggtt attcttctgt caggatgaca agcgaatcaa 1013221 cggaagcggc cacatgggaa acggcgcggc tgacttcctg aagccctcca agaaaggctt 1013281 gcagatcgac gtcgattttg cctgattgct ctttgctgat tttcatgctg tggacgattt 1013341 catcgaataa gcggttaatt tgcgtcattt tttctttact ttcgctgact agctcattca 1013401 cgtctttgat atgcttggat acaatgttga tttgtgtatt cgtattgttc acaagctcag 1013461 aaacagtaga gacggttttt ttcgtatcct cagaaagctt ccgcacttca tttgccacga 1013521 cagcaaagcc tttgccgtgt tctccggcgc gggcggattc aatagatgca ttgagcgaga 1013581 gaaggtttgt ttgttcagct atgcctgtga cgatgccgaa gattttttca atttgctgcg 1013641 cgatttcatc cagcttgacc atttcttttt cgatttggac aaggcttgtg tcaattttgt 1013701 tcatctgttt ttgctggact tctagctctt tttttccgcc gatcgacttt tcttcaacag 1013761 tgctggatgt tacagtgccg gctttggatg cttgagaaat gccttcagat ttgtccacaa 1013821 gctcttgaac tgatctgctt gtttctgaaa acagattggc aatcgatcca gaggtttctt 1013881 gaattttctg atgaagaagg tttttctttt cttcttgttc atcacgggtc tggttgtact 1013941 cgctttgaaa cgcttcaagg acaagctgct gttctaagtt caagattttt gttgttgctt 1014001 taatggcttt tagcagttct tgctgatttg taatggacgc ttcataaatg tcaatcattg 1014061 acaaaaggag ctcttgaaac gcacccatat accattttgg caaaaggccg attcttaaat 1014121 ggatggaggc gattcggtta cgcttttcaa taaattcatc atcgataacg cctgcaaaca 1014181 tttcctgaat atgccgtttt aacgtttgtt ttaagcggtc aactgagctg tgatcattaa 1014241 tgatatccat caatgagctt tcatggtcaa ggtttttata aaacgcatcg acgatattta 1014301 cgatattttc ttgaatgagt ggctgaagct gctctaacac ataaagctca gcatctccca 1014361 acctgaccat tttgagctgt tttttgacat ctgcatgttt gtttgtgagc tgaatgcggt 1014421 ttttttgttg tccgtttgaa tctgaaaagt aagctgtttc ttgttttctg tcttttttaa 1014481 ataacaatac aatgatcccc cttgggaaaa atataatttt tactttttgg ctttttaagc 1014541 ctttttcttt tttatcggcc aagggaaaca tgaatgaagc tgcagatgaa aaatatttga 1014601 aaaaacgttc attaaaatga acggtttaat cgagatctat ttgttttaat ggtttaatgg 1014661 ccggaccctc tacaacttcg ccagatggct taaagcgtga tccgtggcac ggacaatccc 1014721 acgtatgctc actgtcgttc cactcgacct cgcagcctaa atgggtacaa gtcgtatcaa 1014781 cgagatggag gcagcctgtc tcatcacgaa atgctcccgc tcgcctgccg tttatggtga 1014841 cggctttccc ttctcctggc gaaatgtctt caaattggac atcaggcttt tcaagctttc 1014901 cttttatcaa atgcttggcg acatctgcat tgtaggaaat cactttctgc aacccgggat 1014961 tcagatggaa acgggacggc gtgaaaatgc tttcgtatgg gttttctttt ttctccacaa 1015021 ggtctgacaa taaagtggct gcgactgctg aggacgtcat gccccatttt ttgaacccgg 1015081 tcgctactag aatattgtcc tcattttccg acatcggccc gataaacggg attttgtcga 1015141 tcgtcactag atcttgggtg gaccaataat atggaatgct ttcgatgccg atggtgcttt 1015201 cggccagttg tctcagtgtt tcataatgtg tagacatggc ttttccctgg cctgttttat 1015261 ggcttactcc gctgaagaga atcagctttt caccgtttac aaccgtatag cggagcgcca 1015321 ctgacggctg atcgatactc aaatacatgc cctcgggata ctcgatcttc ggcttgatgg 1015381 caaggacata agatctgtcg gagtacattc tcgcagcata taatccgcct ccgtcataaa 1015441 aagggaagtg ggaacagcat atgataaagc ggctcttaat ggcgtgccgg ctttttgtta 1015501 ccacttcggg cctttcgcct tttttgatat caagcgcaac ggtctcttca taaattcggc 1015561 cgcctttttg aacaatttgc tccagaagcg cttttaagta ttgaagcgga tgaaattgag 1015621 cttgattctt catgacaagc gccagcttag aacctaaggg aattggaaga tccttgataa 1015681 ggtctctttc aattccgagc tttgtgtatg cctcatgctc ggtgtggatt ttttgaacag 1015741 cgttttcatt tgccgtataa agatatgcgt cttgctcgat ccattcacaa tcaatttgat 1015801 gttcatccac aatgcctttt atgtaatcaa ttgcgttttg gtttgcttca taataaagcc 1015861 tcgcatggtt taatccgaaa tggcggataa attcgtcgta tatcatgtca tgctgtgcgg 1015921 taactttagc agttgtatgc gcagtggttc cgttaagaac ctgatttgct tcaatcaaaa 1015981 cgacacggaa gcctctcttc gtaagttcat atgccgttgt gattcccgta atcccgcctc 1016041 cgataatggt gacgtcacat tcagtgtcct cttgaagcgc aggaaaagaa ggcaggtcag 1016101 ttgatgtttt ccagtatgtt tcaggtgctt cctttgcaaa atgttgatta gccaagccgt 1016161 tatacctcca atcagattta ttcttaattt ttccatattc tatcttttca tacataggaa 1016221 gcaggcattg ttcataacat aataaggttg aaaaggagtg atttcattgg cgaatcaaaa 1016281 aaagaaaaca ttaccgcctc agcaccagaa ccagcagcct ggttttgaat atctgatgga 1016341 cccgcgtccg gtttttgata agccgaagaa agcgaaaaaa ttagagggca aaaccgctat 1016401 tattactgga ggagacagcg ggattggacg cgctgtctcg gtgttattcg caaaagaagg 1016461 ggctaatgtg gtcattgtgt atttgaatga acatcaggac gccgaggaaa caaagcagta 1016521 tgtagaaaag gaaggggtaa aatgcctgct gattgcagga gatgtcgggg atgaagcgtt 1016581 ttgcaatgat gtggtcgggc aggcaagcca agtgtttcca tccattgata tattggttaa 1016641 caatgcagct gagcagcatg tccagcccag cattgaaaaa atcaccagcc accagctgat 1016701 cagaaccttc caaacaaaca ttttttccat gttttactta acaaaggcag tgctgcctca 1016761 tttaaaaaaa gggagctcta ttattaatac cgcttcaatt accgcctata aaggcaataa 1016821 aacgctgatc gattattcag cgacaaaagg cgcgatcgtt acgtttacaa ggtccctttc 1016881 ccagtcgctt gttcagcagg gcatacgggt caatgcagtg gcaccgggtc ccatttggac 1016941 accgcttatc ccggccagct ttgccgcaaa agacgtggaa gtgtttggtt cagacgtgcc 1017001 gatggaacgc ccggggcagc cggtcgaagt ggcgccaagc tatctatacc ttgccagcga 1017061 cgattccaca tacgtcacag ggcagacgat tcacgtcaat ggcggaacaa ttgtgaacgg 1017121 ataataaaaa gccaatcctt gaaggattgg cttattcgct ctgcttgagc gctgcatatt 1017181 ctttagagag cgtaagaaac gcatctttat ctttttcgtc caaggctttg ttaatttggt 1017241 ccgtcagcat ggcaagccga cggttataca aggattcatc gagcaccatt tgaatgtaaa 1017301 tatccgtcat tgtgacatcg aattcttttg ttttttgcgt gttgcgggac ttcatgagct 1017361 cagtgtacga ttttttctct ttcataaaga atccccccaa tgcctttttt atagtatatg 1017421 gataacggtc gaaaaaatca ataaattttt ataattttta gacaactaat acttggcaat 1017481 ctatcgacat atcctgcaaa atgccgtaaa ccggcaagtc ttatgaaagt aaaatcggtt 1017541 tattactagt catttagtac cattaaatat cattaaaaga tgattttatc ttaaatgtta 1017601 aaaaaacctg tcgttttaca aaaacagatg atagattatt agtataaatt ttgcagaaaa 1017661 aggatggagg ccataatatg agtcagaaaa cagacgcacc tttagaatcg tatgaagtga 1017721 acggcgcaac aattgccgtg ctgccagaag aaatagacgg caaaatctgt tccaaaatta 1017781 ttgaaaaaga ttgcgtgttt tatgtaaaca tgaagccgct gcaaattgtc gacagaagct 1017841 gccgattttt tggatcaagc tatgcgggaa gaaaagcagg aacttatgaa gtgacaaaaa 1017901 tttcacacaa gccgccgatc atggtggacc cttcgaacca aatcttttta ttccctacac 1017961 tttcttcgac aagaccccaa tgcggctgga tttcccatgt gcatgtaaaa gaattcaaag 1018021 cgactgaatt cgacgatacg gaagtgacgt tttccaatgg gaaaacgatg gagctgccga 1018081 tctcttataa ttcgttcgag aaccaggtat accgaacagc gtggctcaga accaaattcc 1018141 aagacagaat cgaccaccgc gtgccgaaaa gacaggaatt tatgctgtac ccgaaagaag 1018201 agcggacgaa gatgatttat gattttattt tgcgtgagct cggggaacgg tattagaaaa 1018261 ataggaagga gctgaccgaa cagggcagct cctttcataa agctatgccg tcggaattcc 1018321 tccggtgatg ccatatacct gagatgtcac atagcttgaa ttctctgaag ctagaaatac 1018381 ataaacatcg gccaattcca ctggctgccc agcgcgattt aatggagctg gcggcgtgcc 1018441 ttgtccgaat ttcgggatgt tttccgtcgg ctgtccgccg gaaatttgca gcggtgtcca 1018501 aattggtccg ggcgcaactg aatttactct gatgcctttg gaagcaagct gttttcccag 1018561 tccgacggta aagccgataa tggcgttttt cgttgctgcg taatctaaca gcatcgggct 1018621 tggattatag ccttcaactg aggtagttgt gataattgaa gctccctccg gcaaatacgg 1018681 aagcgccgct tttacaaccc agtaaaggga aaagacgttc acttcaaatg ttttatagat 1018741 ttgttcagta ggcagatctt cgatgttttc gaccgcttgc tgtttgcctg caacgagcgc 1018801 tagcacatca agtccgccga gttcgtgatg cgactgtttg actagatctt ggcaaaagga 1018861 ttcgtcgctc aagtctccgg ggatcagcac tgcttttcgg ccttctgctt caatcagctc 1018921 ttttacctct tcagcatctg gctgttcctc gggcaagtag ttaatagcca catcggcacc 1018981 ttctctggcg taagcaattg cggcagcgcg gccgataccg gaatcgccgc ccgtgacaag 1019041 cgcttttcga cccgttagtt tacctgatcc tttgtagctt ttttctccgc aatcagggac 1019101 aggcttcatg ttcttttgca ggcctggcgg ttcttgatat tgttcgggaa attcatcatg 1019161 aaaaaatgct tttataggat tcgtaagatt tgaatcagac atcagcaacg ctccttttct 1019221 gtttggtgta cattcgtatg tgtacccctg agcataagca gaaaaacatg ttttggcagt 1019281 ttgaatagtg aaggaaaaag aaaacaagaa aaaacaaagc cttcttccat atttatcttg 1019341 tcaaataaga ctatatgaat tatgataaat tcgagctata aatcaactaa atattgggtg 1019401 ttgggagagt gaatcgtcat gaaaaaagcg gcggcggttt tgctgtcact cggtctcgtt 1019461 ttcggttttt catacggagc tggccatgtg gcggaagcca aaacaaaggt gaaggtctat 1019521 aagaactgca aggagctaaa caaagtatac aaaggcggag tggcccgcac atcgaaggtg 1019581 aaaaacaaag gcggaaaaac gaagtacaag ccttacgttt ctaaggcact ttacgatgcc 1019641 aataaaaaca aagaccgcga taaagatctt atcgcctgtg aacggtaaat aagaaaaagc 1019701 aatctggtgt ccagattgct ttttttatgc ttaggccgcc tgatcggccg cagcgctttt 1019761 cgccttcctt gtcataaggc tgactgccat catgaccgtg atattcaaaa gcagggcgac 1019821 gatgccgaca ttcaagtctt ttgcggcttg cggcagagcc ggaaataaag tgccgatcgt 1019881 cgtttccgtc attgtaatat aagtaactgc tccgacacct gcaataatgc cggcgaaagc 1019941 tccttgcttt gtcaccatat tatgcttgag caggctgaac aaaagggcgg ggaatagctg 1020001 tgtgacaagg ctgtagccca tcaaaagcag cgtaacgatg gtattcccgc ctttgaaggt 1020061 aaaatacacc gaaatcagcg caatcaccgg cactaaaaac ttagcaagcg ccgatacttg 1020121 ctgttctgtc gtgcggggcg cgattacctt gtacacattt tttgcaaaca gtgtggaggc 1020181 ggacattaag atcatagacc ctggcacaag tgctgtcagc agtccggcag caccgataat 1020241 tccgacaaac caagggtcaa atgcttgcag agacagtctc aaaagcgaca aatccccgtc 1020301 tgcgccattc agatctggaa cttgcaggat agccgcaaag ccgacgaaaa ggacgaagag 1020361 caggaccagc tggtacaaag gcatgatgat ggcgttttta cgaaacactt ttgggttttc 1020421 ggctgaatac gaagcggaaa acgtgtgagg ccacatgtaa aaaccaagcg ctgtcaagag 1020481 tacggttgaa ctgaaccagg ccacactttg tcccgattcg gggagcgtaa gaaagccagg 1020541 ctttgccgtt tcaatctgct gaaacatgtc ttgaaatccg ccgtagtaat gaattggcaa 1020601 atacacacct aaaaacagaa cgacaaccag aatcatgatg tccttcacaa ccgatatcca 1020661 ggcagacccg tgaatgcctg aaaccataac ataaaccgtg atggaaacag cgccgatcca 1020721 gatggcagcg gtcggggtga ttttgccgta cgaggtttcc gatacaatca gcccgaggcc 1020781 tttcagctgc agtacaagat agggaatgag tgcggcgatg ccgaccagtg aaacgagaat 1020841 gccaagcagc ggactgttgt atttttttgt gaaaaaatca gactgcgaca tcagtttatg 1020901 ctgtttcgcg tacgtccaaa ctgctggaag aagccagtaa gaaaggatgt aggccagaca 1020961 tccgtaggcg atgatataaa aggctggacc gccttttccg taggcccagc cgctgccgcc 1021021 gagaaacgta aaagtagtat aaatttcgcc tgccatcaaa aggaagacga aaacagttcc 1021081 gaagccgcgc cctccgaccg tccactgctc caggttcatg tcttttcctt tttgggcgcg 1021141 tataccgaga aaaatactca agagcaggac accgaagatg atgatgagag ctgcattcat 1021201 tctgcttcct cctttttatt ttccttgtcg aggacataca caatcgccat cagcgcagag 1021261 gtcaaaagag cccacatcac aatataggca agaataaacg gcatgccgaa cacatagggg 1021321 gtcaccttat ttgcaaaagg gatgccgagt aagattccga taaagggtaa agcggcaaga 1021381 acgtgaatca gtttcataga atcctccttc tatttaggat tgaggtgtac aagcctaagc 1021441 gtactgaaaa tgatgtcgca gatatcgcag cacatgtcat tttttggagt gaaaggctgt 1021501 ggttcgaatt ataaataaat ttattttgtt tgtatagtgt gaattgtctg aaattaatgc 1021561 tctgaatcgc ccgaagaggg aacgggcagt atgattcaaa aggctcagag tctgtctggg 1021621 gcaaatagat agtatgttaa taattcgctg acctgctcac ggattcgcgg attaaaatag 1021681 cgatggtttt cttcataacc gtcgatgaca aatgtataga gtgtaaaggc ctcatcgcgt 1021741 tccgtctcgc ggattgcaat ttttcttttc ctcagttctt ttctgacctc catcaaatcc 1021801 ttttgtgcta tttttaatga ttcgctgata agctgtttat aaggatgctt caattttaat 1021861 gtgctttctt caattccggc gagatcacgg ttaaaaatcg taatggccat gggcaaaaag 1021921 agagcccgtt caattaaatc gtatatttcc tcctgcagat ttggcatatt gactccttct 1021981 ttctaaggga acgtttgttc tatttgtatt ctatatcggc tggtgaaatg tttcaagaca 1022041 gaaaaaatca ccaaaacttt ttagttttct gctgataatg tgtagaataa ggatagacaa 1022101 acccggtaag gagtataaat gttggagcat tttttatcct atttgacaca agaacattta 1022161 actgaattat ttcaaagcta tagggctttc ggtccgctca ttgctgtgct gctgccttta 1022221 attgaagcat ttctcccgtt tttgccgctg atcgtgtttg tggtggcgaa tacgaactcg 1022281 tttggcttgt gggaaggatt catcctatcc tgggcgggat caactgctgg ttccattctc 1022341 gtctttttga ttgtccgtca atacggacag agaaaattgc ttggatttat ccgcagtcat 1022401 ccgtctgtca gaaagctgat gttatgggtg gaaagacacg gcttcggtcc catgtttctt 1022461 ctgctttgtt ttccatttac accgtcagcc gcggtgaatg ttgttgccgg tttgtcaagg 1022521 atcggaacgc ggccgtttat tttggcggca gcctcgggga agcttgtcat gatttttatg 1022581 atcagcttca tcggatatga tctgcacgcg ctgattacac agccgattcg aacggtcatc 1022641 gccgtattgg tgatcactgt cttatggtat gtcggcaaaa aggtggagcg gtatctgcat 1022701 gtaagagcca gtcagcgtga gcatgatgga gggagacagt aacatgaaaa aacggttttg 1022761 gtttcttgcc ggtgtagtgt ccgttgttct cgccattcag gttaaaaatg ctgtctttat 1022821 tgattacaag gtagaaggcg tcagtatgaa cccgaccttc caggaaggaa acgaattgtt 1022881 ggtcaataaa ttttcgcatc gatttaaaac catccatcgt tttgacatcg tcctttttaa 1022941 aggccctgat cataaagtgc tgattaaacg ggtaatcggc ttgcccggtg aaacgatcaa 1023001 atataaagat gatcagctgt atgtgaacgg aaagcaggtt gctgagccat ttttgaagca 1023061 tttgaaatct gtttctgccg gcagccatgt aacgggtgat ttttctttga aagatgtgac 1023121 gggaacaagc aaggtgccga aaggaaaata ttttgtcgtt ggagataatc gcatatacag 1023181 cttcgacagc cggcattttg gtccgataag agaaaaaaat attgtcggtg tgatttctga 1023241 tgccgaataa aaagacgcta attgaagagg cgtctttttg tatgccgttt ggaaaaatgt 1023301 gttgaagaaa aatttgtaag gagctataat caaaattgtt acctgtgtaa caaaatttat 1023361 atattttttt gactggaggg ccgtttttat tggtttttgt tcgtttttca tgaaacaaaa 1023421 ggagtggtga atgatgatga aatatgaagc agtgattata ggaggagggc cggttggatt 1023481 tatgctggct tctgagcttg caatagccgg agtgggaaca tgtgtgattg aacggcttga 1023541 aaaacctgtt ccgcattcca aggcgttgac gctgcacccc cgaacgctgg agcttcttga 1023601 gatgagaggg attttagagc ggttcgtatc caagggaagc aagataccta ccggacattt 1023661 ttcaatgctg gatacccgtc tggatttttc aggcttggat acgagctgtc cttacacgct 1023721 tttgctcccg cagtccaaaa cagaaaagct tcttgaagat catgcacgaa gcctgggaac 1023781 agaggtgttt cggggtgccg aggcgctggc ggttacgcaa aacggggaag cggtccaaac 1023841 aatttttaag gatcgggacg gcagtgtacg gacgatcaca agcaagtttg ccgttggggc 1023901 agatggcgcc gggagtaccg tccggaaaca ggcgaaaatt gagtttccgg gaacagacag 1023961 cactgtcacc gctgcgcttg gggatgtggt gctcctttct ccgccgccgt caggtgtgct 1024021 gtccctttgc acaaaagagg gcggtgttat gattgttccg ttatctccag accgataccg 1024081 tgtcgttgtg atcagccctt atcgcacaca aacgccgaaa gatgtgcctg tgactgagga 1024141 agagctgaaa gctgacctcc tgcgaatttg cggaactgac ttcggtttaa ccgacccttc 1024201 gtggatgtcg cggtttggga acgccgcgcg ccaagcgaaa cggtatcggg acggcagaat 1024261 ctttcttgcg ggtgatgccg cgcatattca ttttccggcg ggcgggcaag gactgaatgt 1024321 cggccttcag gatgcaatga acctcgggtg gaaactggcg gcggccatca aaggctctgc 1024381 gccttcttgg cttttggaca gctaccatga tgagcggcat ccggcagcgg aagggctcct 1024441 cagaaacacg gaggcacaga caaagctgat cgatttcact caagcaggcc tccatttgcg 1024501 aagcatgatg tcggagctgc tggccttccc tgatgtgaat cgatatgtag cggggcaaat 1024561 ttctgcgctc gatgtcagat atgaagctga tcgtaccatg ccgccgaatc gtttgaacgg 1024621 ggcaaggctc cctgacatga agctgattct ttccgacggc aattcggaac ggctgtacag 1024681 ctttctccaa aacgggacat tcgttttgct gtcattgagg caggaagctg atgatcatat 1024741 cgaagtaaaa ggcttacgta cggtaaccgc ctcgcttgca gaaccgaatg aaaagttgcg 1024801 gaatgtgcat accatattga ttcgtcccga tggacatgta gcctgggcgg tggatgcatc 1024861 agcgcccgat tgttccgagg tgattcaaaa agggatcagc cgctggtttt ccgtcaccag 1024921 ccgagtataa ttcaattcga ttgtttcatc tgtaacaaaa cggtatgata gaagaaacaa 1024981 tcgaatgaaa aaggatggaa aacccgatga acacagatca tacgaaacgc aatctttttg 1025041 aattgtatgc ggagctcatt catcagcagg agaaatggga ggggcttatt aaagcctttt 1025101 tatctgacga attgaggaag ctggatgtag agcacgggag taaatctcaa ttgacgatga 1025161 cagaaattca tgttctatcc tgtgtcgggg acaatgaacc aattaatgtc acgtcgatag 1025221 cagaaaaaat gaatacgaca aaagcgactg tatcacgcat cagcacaaaa ttgctcggcg 1025281 caggcttcct tcacagaaca cagctcagcg ataataaaaa ggaggtctac ttccgattga 1025341 cgcctgctgg aaaaaagctg cacagtttgc acaaatatta tcatcagaag gctgaacagc 1025401 gttttctgtc attttttgac cgctataccg aggaagagat tctttttgcg gaacggctgt 1025461 ttcgggatct ggtgacaaaa tggtatccgt cgtcagaaga aattgaaggg gggcttccta 1025521 gcatttttaa ataaaaaaca cgcactgcgg tgcgtgtttt tcgctttgcg gccgcctcga 1025581 gaattctttc atttcaccct ctggcagcac tcacttcaaa tctgatccat taacaacgaa 1025641 atatccgctt atatttcctc atctcgatgg tttgcgaatt aaaagttctt gaaccctttt 1025701 ttcaactagg cactactgcc gctgattgag ctctttttgt cttttttttc accatgaaga 1025761 tggtgaagca ggcgataaaa cggcggcagc agggcaataa ccagaatgac gcgaatgacc 1025821 tgaaccgcaa cgacaaaggt ggaatcagca tgtaaggtaa ctgacgtcgt cgccatctct 1025881 gcaatcccgc cgggcgcaaa tgccagaaca gaagtgatga gcgaaattcc tgtcagctcg 1025941 gaaacgatca cggcgctcaa aaacattgct gcgattaaac cgacggacga gacaaacccg 1026001 acgatgataa tacgggtgac gccggcaaac atgcttttgt acatcttaga gccgatcgtt 1026061 gccccgagaa atacttgtga tacatggtta gcttgtgaca accaccatgc cgtcatgtcg 1026121 tgccctgtca ccgcagctcc gccaacatgt acaattgcta caccgagcat gctgccgagc 1026181 agccatggag ctggaaattt taaaaatttc gcagctttgc aagctcccca ggcagcgaga 1026241 ataagaatga cggtccacaa aacgggagcg agcctaaaat ctgtcgttgc agaagaaatc 1026301 gtctctgctg cggcacttgc ggtacgatct tgttttgtat agatcagaat gactaaaaac 1026361 ggaatggaaa gcaccacgag cagcacacgc atcatttgaa cgaggctgac tatagcggta 1026421 ttggcgccta cttcctgtgc gatgctcggc atggcggaaa gtccgccggg agcggtgccg 1026481 acaaagctag tcatcatatc cgttttgctg aaacgccaaa gcacatatcc tgacagcatg 1026541 gccagcagga tagacaatat cagcataacg ccgactgaaa accaatggtc tttgagaaca 1026601 gagagaacgg ataaattcag cttttggccc aattcgatgc cgaggatcat ctgcccgagg 1026661 gcgagccatc gtcggttaat tcctttttgg tctggtgcca tcatcagcca tgccggccgt 1026721 atcatggcga ggcagcaggc gacaatcagt gttccgatca tccatccaat tgatattccg 1026781 gttaatgaaa gaataaaccc cccggctgca ctgattgcga taaaccatag atctttgagg 1026841 agattttcgt ctttcttcaa tgtaaaaccc ttcttccttt ttcacgtaac actccaattg 1026901 ttcacgtagt gaatgtattt attactatag tatatttttg ttgataaaga aattatgaat 1026961 tattttctat aagcgattca cttttcttat gaccttgtgt tcgagctttt ctattgtgta 1027021 agtcagagat aaacccgctg tcagcagaca cacggcaaga gcgtaaaaaa tcacttctcc 1027081 gccaaatgat gtcaggatca gcccgcctgc cagcggtccg attgagcggg atatatccca 1027141 atgcagacca tagacagcat aaaaccggcc cagcaaatga ggcggcgcca atttcgatat 1027201 gaaggtctgg atgtgggtta gcccgatgct ttcaccaacc gtcatcaccg ctgccgtcac 1027261 taaaagcatt gtcagagagg ttgagcatgc aaagccggct gccgcaaggg agtagcaaat 1027321 ataagtaatg aagaggatcg ttttcattga aagcttttcg gtccctttga caagaggtac 1027381 ttggagaaca cagctgaata aagcttttgc tgctgaatag atggtcagca tggacagata 1027441 atcagaaaac atgtttttgc tgaacagcct gtatgttgtt tctgtttgtg catataacat 1027501 gctgatgggg agagaaagca gcaaaagaag caggacaggc ctgtatattg taaagctcgc 1027561 ggacattttc ggggtaacag ctgggtgtag cggctttgtc tcaggcagtt tcagtgcagc 1027621 gatcagaaag tagataaaca atgctgcagc atctaatgcg aatatccaca cggggttatg 1027681 attgtacagc agcatcccca ctagcggtcc tgccgtcaga cccgtcgaat agatcgcatt 1027741 gatgaccgca aacacttccg aacgtctgct ttccggcgtg ctttcagcga tttgggcgcg 1027801 ggaagcggga atgtacaacg atcttccgat gccattcatg acatagagaa tagcgaaaac 1027861 atacgcatgc tcagcaaata caaaccctgt cattgccgct gattgaagaa gcaatgcggt 1027921 caaaatcgct gtgcgccgcc caagccgatc cgtcacccgt cctgcagcga gcgtcaggaa 1027981 aatatcagca aatggctgaa ggctgatgat cagcattggc atcatgatac tgccgtttaa 1028041 ttgttcatgc agatacagca ccataaaagg tcccatcatt gcacctgtca ggcttgtcag 1028101 caattcgccg aaaaagcgga gccgaacggg agcggtatat ctcgatttta tagagtgaaa 1028161 actggtcaac atgtgatcgc cgcctttcgc tgtttgatat agtagtagtg tatagaaggg 1028221 gcggcggccc aaaaagtgaa gaaaagaaga gataaaagtt ccccttttgt cgggaggtgc 1028281 ggggattgaa gctgatagag cactacgtgg cgcttgtaaa aacaggctgc gccgagtatg 1028341 ggcaaatgaa cgaaatgacg ctcactgaga ttgccgactg tttattttgt acagaaagaa 1028401 atgcaaagct cattttacat aagctggaga acagcaattg gattatccgg gaaagcgggg 1028461 cggggcgcgg ccgcaaatct aaaatcgcgt ttcttcggag gcctgaggaa ctgcttcttc 1028521 aaactgcaaa ggaatatacc atgtcaggaa agcttaaaaa ggcaaaggag ctgcttcagc 1028581 agtatcagtc cgcgtttcca gggcttcaaa acgaatataa catgtggcta tcagaggtat 1028641 tcggatttgt gacggagaca ggcgagaatg gggcgaagga tgtcctgcgg ctgttcatca 1028701 cgcctgaatc tgtcagcagt ttggatccat gccaaatatt tttgcggtct gagggccatt 1028761 tcgtcaaaca gatatttgat acactcttca cgtttgattc ggatatgcag gagccgaagc 1028821 ctcatttggt tcatggatgg gaagaggtcg gaaaaaaaca atggagattt tttcttcgaa 1028881 aaggtgtgtt atttcataat ggacagccgc tgacatcgcg ggacgttgcg tttacatttc 1028941 agcgcttttt ggaactggct gacaacccgt ataaatggct tctgcacgga gtgaaacaag 1029001 tcttagaaaa gggcccttat tgtgtggagc tcatactcga taagccgaat gcgcttttgc 1029061 cgtatgctct ttgtgatgaa cggctgtcca tactgccggc agaacagggc ggcgggaaaa 1029121 atggaacagg gccttttcag atgaatcagc aacatagcgg gatgcttgtg cttgaagcca 1029181 atgagcgcta cttcaaggga cgcccctatt tggatcgcgt tgagtttgtg ttttctgagc 1029241 aagccggaga gatgaacggt tttaccattc aagaaaaaca aacatgtcct gagcagcaaa 1029301 ctgtctttga tgagcggcat gttcagtatt tgtcgcttaa tctgaaaaag aaggggcctc 1029361 ttcagcaccg aagctttaga aaagcgctcc ggctgctgat ttcctctgaa cggctcgttc 1029421 gtgaagcggg agggcaccga agaattccgg ttacgtcctt tttgcatccg agtccttttg 1029481 agtgggaggg cgtttcgcca tctgaattgt tgaaaaaaag cggatacgag ggcgaaacaa 1029541 tcgtgcttta taccttttcg gaaacggatc atcgtgagga cgccgaatgg attcaaaata 1029601 tttgcgccca gcacggtatc aggcttacac ttcaattctg tgatgctgct gatctgcgac 1029661 ggccggaaat cgtgcagatg gcggatatca ttcatgacag tgcgacgttt tatcaagaca 1029721 gcgagtttgg ttttctgcat ttgctgctgt cggagaacag tttcttgtat cagcatctat 1029781 ctgaaaagct gacacagatt tgctcaggaa tgacagagcg gatgttttcc atgcctgacc 1029841 gctgttcgag aatcaacatc ctgcgtgaca ttgaccggca gatgatacag gagctgaacg 1029901 cgatcccgct gtatcaaaat gtgctccagg tgacatcaag taaaaatgta aaaggcctgg 1029961 tgcttgatga agagggatgg attgatttgt actccgtatg gctgtccaaa taaaaagagg 1030021 gttctttttt gaaccctctt ttttacgctg ccatgctgcg gcattgttca gcacaggtga 1030081 agcaggcttt cgcacatgct tggcaatgat catgatcgtg ctttccgcat tcagtgccgc 1030141 atgcttcaca aatatcggcg caaagtgcac aaatttcttt cataaacggg ctgtccgttt 1030201 gcatggcttt gaccgccagc gcgcaaatat ccgcgcattc cctgtcaagc cggatgcatc 1030261 cgctgagatg atgctgcacg ctttcttcca agcatttagt gaaacaatga ttgcaagcct 1030321 tcatgcaatc gatgcaagcc tcaatacaag cctcagaata ttgctccatg gttgattccc 1030381 cctgtatgac agtatatggt tttatgtttc acggctgcat ttgaaaaaaa caggggagtg 1030441 tgtttttagc taaggggata tgtacatata ccctgaatgg gtatatctaa cgttccatca 1030501 gatagtatag gaaccagaca gcgtgatttt gttcatcacg tgctgcgcgc gtaaagacgc 1030561 ctttcgcttt taagtttgac gtttcctcgg ccgcacgcaa gtaaaagtcg acggtttctt 1030621 gttcatcttt aaaagcggcg tccagtcctc ttgtgaaatt gtccgggcat tcttccgttt 1030681 gtttcggcat gatgtgtttg ccggtaattg aaccatacag tgtggaaaat tcacggaggt 1030741 ggcgaatctc gtcacgcctg atttcttcaa tctgttttct gacctcatcg ctgtgggcga 1030801 gttcggcaag cttgcggtag cattgaatag cactgaattc tccgttgatg gccttctgca 1030861 aattccgaat caaaacagga tcttcccggt atggcaccgg atagggatag tagctgtaat 1030921 gcaaggggat tcaactccat tcttaggaat tgggcttctg taaaagtata tgttgggcag 1030981 ggagagatgt gcggagataa tcagcttttt atatgtgaaa aggccgtttt taccaataga 1031041 tcagattggt cattttcgtc aacattcgat aaaatataga gagataaaaa gagaggggtc 1031101 ttctaatttg ggagcagagt ttttagtagg caggtccggg agtggaaaaa cgaagctgat 1031161 catcaacagc attcaggatg aattgcgccg ggctccattc gggaagccga tcatttttct 1031221 agtcccggat caaatgacgt ttttaatgga atacgagctt gctaaaacgc cagatatggg 1031281 cgggatgata cgcgctcaag tgttcagttt ttcacgattg gcctggcgcg tcctccagca 1031341 tacgggagga atgagcaggc cgtttctgac gagcaccggc gtacaaatgc tcctgcggaa 1031401 gctcattgag gagcataaac aggagttcaa agtctatcaa aaagcgagtg acaaaagcgg 1031461 gtttaccgca caggttgagc ggatgctgac agagtttaag cgctattgtc tggaaccgga 1031521 ggatatccgc cggatggcgg aaagcggaac ggcttccgag tatcgcggag aacgtgtttt 1031581 atctgaaaag ctccatgact tatcaattct gtatcagcaa atggaaaaaa gcctcgcaga 1031641 tcaatatctt cactctgagg attatttgac attgctggca gagcatatcc cgcttgcgga 1031701 agatataaaa ggcgcccata tctatgtgga tggcttttat cagtttaccc cgcaggaatt 1031761 cagggtgttg gagcagctta tggttcatgc ggagcatatc acgttttcgc tcacagcgga 1031821 caagccgtca tatgagcggg agccgcatga actggaattg ttcagaatga cggggaaaac 1031881 ctattaccgc ctgcatcaga aggcgaagga actgaatttg gacattacgt ataaagagct 1031941 gagcgggact gagcggcata caaagacgcc ggaattggcg catctagagg cacagtatga 1032001 agcgcgtccg gccattccat acgcagaaaa acaagaagcc cttactgtga tgcaggccgc 1032061 aaacagacga gctgagctgg aaggcattgc tcgggaaatt cacgccctag tcagagagaa 1032121 gggatatcgc tataaggatg tagcaattct tgcgcgccag ccggaagact acaaggatat 1032181 ggtgaaggaa gttttcgcag attacgagat tccttatttc attgacggaa aagcatctat 1032241 gctgaaccat ccgttaattg aatttatccg gtcgagcctt gatgttctga aagggaattg 1032301 gcgttatgaa gcggtgtttc gctgcgtgaa aaccgaactg ctattcccgc tcaatgaacc 1032361 gaaggccaaa gtgagagaac aggtcgatca gctcgaaaat tactgtatcg cctatggtat 1032421 taaaggcgac cgctggacaa agggcgatcg gttccaatac aggcgttttg tgtcattgga 1032481 tgatgatttt gcgcagactg atcaggaaat cgaaatggaa aacatgttga atgacacccg 1032541 cgattggatt gttccgccgc tttttcagct tcaaaaacgc atgaaaaaag cgaagacggt 1032601 tcaagagaag gcggaggcgc tctatcgtta tttagaagag acggatgtgc cgctgaagct 1032661 ggatcaggaa aggcagcgtg ctgaggatga cggcagaatc attgaagcgc agcagcatca 1032721 gcaggcgtgg gacgcagtca ttcagctgct tgaggagttt gttgaaatga tgggagatga 1032781 tgagatttct cttgatttgt ttcagcaaat gatagaagcc ggcgcggagt cgcttacatt 1032841 ttctctaatt ccgcctgcgc ttgaccaggt gtttgtcggc aatatggatt tgtccagaat 1032901 gtatggcacc tcctgcacct ttgtgctcgg ggcaaacgac ggcgttctgc cggcacgccc 1032961 tgatgaaaac ggggtcctgt cggatgatga ccgggaatgg ctgaaaacga ttggggttga 1033021 gctatcctca ggcggacgag agcgtttgct tgatgagcac ttcctcatct acatggcgtt 1033081 ttcaagtccg tctgaccggc tttacgtatc gtatccgatt gctgatgcgg aaggaaaaac 1033141 gcttttgccg tcgatgatcg ttaagcggct ggaagaactg tttccgcatc ataaggagcg 1033201 cctgttaaca aatgaacctg aacaggtcag cgatgaggaa cagctgatgt atgttgtgaa 1033261 taaaagcgtg gcacagtcct ttaccgcgag ccagctcagg ttatggactc gggaatacga 1033321 catcagcgac gtctggtgga gcacgtacaa tgtgctgatg agtgagcagg acaggctgca 1033381 atcgaaaaag ctgttctcaa gcctgttttt ccggaatgaa gtgaagcagc ttgaacgcag 1033441 cgtgtcgaga cagctctatg gtgaacgtat tcagggcagt gtatcgagaa tggaaacctt 1033501 taacgcatgc ccgttttccc attttgcgtc acacgggctg catttgaagg aacggcaatt 1033561 cttcaagctt gaagcaccgg atatcggcca gctgtttcat tccagcttaa agctgatttc 1033621 ggacaggctg cgtgagcaaa agctggattg gcgcgattta acgaaggagc agtgcgagct 1033681 gttttcctat gatgcggtag agcggctggc accgaaactg caaaaggaaa ttctgctcag 1033741 ctcaaaccgg cattattatg tgaaggaaaa actgcaaaaa attgtgacac gtgtgtccgg 1033801 cattttaagc gagcatgcga aagcgagcgg attcgtaccg atcgggcttg aactgggctt 1033861 tggaggaaaa gggccgcttc cgccgctgac ctttcaactg aaaaacggct gtacgatgga 1033921 actcgtcggg cgaattgacc gtgttgataa ggctgaaagc tcaaaaggcc tgctcctcag 1033981 gattgtcgat tataaatcaa gcgacaaagg ccttgactta gcggaagtat attacggatt 1034041 ggcactgcaa atgctgacgt accttgattt atcgattaca cattcagctg actggctcgg 1034101 gatgagggcg acgcctgccg gagtgctgta tttccatatt catgacccga tgattcaatc 1034161 taatctcccg cttgggcttg acgagattga acaggagatc tttaagaaat ttaaaatgaa 1034221 gggcttgctc ctcggtgatc aggaagtggt tcgcctcatg gatacaaccc ttcaagaggg 1034281 acgttcaaat atcataaacg ccggcttgaa aaaagacggc tctctcagat cagactcagc 1034341 agcagtcggt gaaaaggaat ttgatctttt gacaaagcat gtgcgccgca ccttccaaga 1034401 agcgggcgaa caaatcaccg acgggcgcgt atccattgag ccgtacaaaa tgaagaacaa 1034461 gacgccgtgc acatactgtg cgttcaaatc agtatgccaa tttgatgaat cactggaaga 1034521 aaacgagtat cgcccattaa aggctgaaaa ggacaagaca atacttgagt ggataaaaaa 1034581 ggaggcggat ggcaatgaac attcctaaac cggcagacag cacatggaca gatgaccaat 1034641 ggaatgccat tgtttcaacc ggccaggata ttcttgtggc agcggctgcg ggctctggta 1034701 aaaccgctgt gctcgttgaa cgaatgattc ggaaaatcac cgcggaggaa aacccaatag 1034761 atgtagaccg tcttctcgtt gtgacattta caaacgcctc agcggcagag atgaagcacc 1034821 gaatcgcaga agccttggaa aaagagcttg tacagcgccc cggctcgctg catattagac 1034881 gccagctgtc tcttttaaac cgggccagca tttcgacgct ccattccttt tgcctgcaag 1034941 tgctgaagaa atattactac ttgatcgatc ttgatccggg ctttcggata gctgatcaga 1035001 cggaaggcga gctgatcggg gatgaagtgc ttgacgagct gtttgaagac gaatacgcaa 1035061 agggcgaaaa ggcgtttttt gagcttgttg accgctatac gacagaccgg catgatctgg 1035121 atctgcaatt tctcgttaaa caggtgtacg agtattcccg atcccatccc aacccggagg 1035181 cgtggctgga aagctttgtt catttgtatg atgtatcaga aaagagcgcc atcgaggagc 1035241 tgccgtttta tcaatatgtc aaagaagata ttgcaatggt gcttaacggg gcgaaggaaa 1035301 agctcttgcg cgcgcttgag ctgacgaaag cgccgggcgg cccggcgccg cgtgctgaca 1035361 attttcttga tgatcttgct cagattgatg aactgattca gcatcaggac gatttcagtg 1035421 aactatataa gcgggtgccc gccgtctctt ttaagcgtgc caaagcagta aaaggggatg 1035481 agttcgatcc agcgctcctt gatgaggcga cagatttgag gaacggcgca aaaaaactgc 1035541 ttgaaaagct caaaaccgac tacttcacgc gaagtcctga acagcacttg aaaagcctag 1035601 ccgagatgaa gcctgtcatt gaaacgctcg tacagcttgt catcagctat ggaaaacgat 1035661 tcgaagctgc gaaacaggaa aaatcaatca tcgatttttc ggatttggag cattactgtt 1035721 tagcgatttt gacagctgag aatgacaaag gtgaacgtga gccgagcgag gctgcaaggt 1035781 tttatcagga acagtttcat gaggtgctcg ttgacgaata tcaggatacc aacctcgtgc 1035841 aggaatcgat tctgcagctc gtcacaagcg gtccggagga gactggtaac ctgtttatgg 1035901 taggagatgt caaacagtcg atttatcgat tcaggcttgc ggagccgctt cttttcctct 1035961 ctaaatacaa acggtttaca gagagcggag aaggcacggg gcggaaaatc gatttaaata 1036021 aaaatttccg aagccgggct gatattttag acagcacaaa ctttttattt aaacagctga 1036081 tgggcggcaa aatcggtgag gtcgattatg acgagcaggc tgagctgaag cttggtgcag 1036141 cgtatccgga caatgacgag acggaaacag agctgctgct gatcgacaac gcagaagata 1036201 cggatgcaag cgaggaagca gaagagcttg aaacggtgca gtttgaggca aaagccatcg 1036261 ctaaggaaat tcgtaagctg atttcatcgc cgtttaaggt gtatgacgga aaaaagaaaa 1036321 cacatcgcaa tattcaatac cgagatatcg tgattttgct ccgttcgatg ccgtgggctc 1036381 cgcaaatcat ggaggagctg agagcacagg gcataccggt ttacgccaat ttaacgtcag 1036441 gctattttga agcggtcgaa gtcgccgtcg cgctttctgt gctgaaggtg attgataatc 1036501 cgtatcagga tataccgctt gcctctgtgc tgcgctcacc gattgtcgga gcagatgaaa 1036561 acgagctgtc tttgatccgg cttgaaaata aaaaagcgcc gtactatgag gcgatgaaag 1036621 actacctggc tgctggtgac cggagcgatg agctttatca aaagttaaat acgttttacg 1036681 gacatctgca aaaatggcgc gcgttttcga aaaaccactc agtatctgag ctgatttggg 1036741 aagtgtaccg cgacaccaaa tatatggatt atgtcggcgg catgccgggc ggaaaacagc 1036801 gccaggccaa tttgcgtgtt ctttatgaca gggcgcgtca atatgaatca acggcatttc 1036861 gcggcttgtt ccgtttcctg cggtttatcg aacgcatgca ggagcggggc gatgatcttg 1036921 gtacggcgag agcgctcagc gagcaggagg atgttgtccg cttaatgacg atccacagca 1036981 gcaaagggct cgaatttcca gtcgtgtttg tagcaggtct cggccggaat ttcaacatga 1037041 tggatttgaa caaatcgtac ctgctggata aggagctcgg atttggcacg aagtatattc 1037101 atccgcaatt acgcatcagc tatccgacac ttccgctcat tgcgatgaag aaaaaaatgc 1037161 gcagggagct gctgtcagag gaattgcgtg tgctctatgt tgcattaacg agagcgaagg 1037221 aaaagctgtt tctgattggc tcatgtaagg atcatcagaa acagcttgca aaatggcagg 1037281 catccgcgtc ccaaactgat tggcttctgc cggaatttga ccgctatcag gcgagaacgt 1037341 atctagattt cattgggccg gctcttgcca ggcacagaga cttgggggat ttggctggtg 1037401 tgccagcaca cgctgacatc tcaggtcacc cggctcgttt tgccgttcaa atgatccatt 1037461 cctatgattt gcttgatgat gatctggaag aaagaatgga agaaaaaagc gagcgcctag 1037521 aagcgatccg ccgaggtgaa ccagttcccg gctcgtttgc gtttgatgaa aaagcccgcg 1037581 agcagctgag ctggacctac ccgcatcaag aagtgacgca aattcggaca aagcaatcag 1037641 tttctgagat caagagaaaa agagagtacg aggatgaata cagcggcagg gcccctgtaa 1037701 aaccggctga tggaagcatt ctgtacagac gtcccgcttt tatgatgaaa aaaggcctga 1037761 cagcggcaga gaaagggact gccatgcata cggttatgca gcatatcccg ctgtcacatg 1037821 tgccgtcgat agaagaagct gagcagacgg ttcacaggct ttatgaaaaa gagcttctca 1037881 ctgaagaaca aaaagacgct attgatatag aagaaatcgt gcaatttttc catacagaaa 1037941 tcggcggaca gctgatcggt gctaagtgga aggaccggga aataccattc agcttagcgc 1038001 ttccggccaa ggagatctat cctgatgcac acgaggcaga tgagccgctt ttagtgcagg 1038061 gtattattga ctgtctctat gaaactgagg acggattata tctattggat tataagtcgg 1038121 accggattga gggcaaattc cagcatggat ttgaaggagc ggccccgatc ttgaagaaac 1038181 gatatgaaac gcaaattcag ctgtacacga aggcagtgga gcaaattgca aaaacaaagg 1038241 taaagggatg tgcgctttat ttctttgacg gagggcacat tctgacatta tagcgagatc 1038301 cataagctcc ggaatttcag gcggagcggg tctcgttttc tatataaaag agaggtgaaa 1038361 gcatttgcgg attttacata cggctgactg gcatcttgga aaaacgcttg aaggaagaag 1038421 caggctgagt gaacaggccg atgtgctgga tgaactgaat acgattgtaa aggatgagca 1038481 gatcgatgcc attgtaatgg cgggggatgc atttgacacc gtaaacccgc cagctttagc 1038541 cgagcagctg ttttatgaaa gcctgtctgc gcttagcgac agaggaaagc gcccgatcgt 1038601 cgtcattgcc ggaaatcacg ataatcctga ccgtttgtcc gccgcttcac cgctgacaca 1038661 tgaaaacggc attcatttaa tcggttatcc gacaacagag ccgattcata ttgaagtgcc 1038721 ttcagcagga gagcttttgg cggttggagc gctggcgtac ccatctgaag cgcggttaaa 1038781 tgaagtgcta tccgatacgt ttgatgaaaa gctgctccgt gatcactatg atgtgaaaat 1038841 caggcaggcg tttgagcata tgacaagccg gttccggacc gatgcagtga agattgccgc 1038901 cagccatatt tatgtggcag gcggaaacca aaccgattca gagcggccga ttgaagtcgg 1038961 cggtgcatac acggtggctg ctgaaagcct gccggcagat gccgcttacg ttgcgctcgg 1039021 ccatttgcat cgcccgcaaa cgatcaagcg ggcgcggacg cttgcgcgtt attcaggatc 1039081 tccgctcgcc tacagctttt ctgaagcggg ctacgctaaa tcagtgacga ttgtggacgc 1039141 aaagcctggg gaagaggcca cttggcaaga ggtgttatta tcaagcggca agccacttgt 1039201 gaagtggaaa gcggcaaatg gattaagtga ggtgtacagc tggctggatg aaggcagaga 1039261 tcagaatgct tggattgact tggaaatccg tgtcgcggac cagctgtcac ttgaagagat 1039321 tcacaggctg cggaaggcgc acccgggctt tatccatatc aggccggttt ttgaagaaca 1039381 gaacaaagac cgggaacgga tcgaggttaa acatgtctca atcgaggacc gctttaagaa 1039441 attttatgaa aaacaaactg gcggtgcggt gccggatgaa gaaatggtga agctgttttt 1039501 agagcttgca tcaggcgttg aagaggagga tgcgaaatga agccgatcgc cttaagcatt 1039561 aaggggctcc acagctttag agaggagcag acgatagatt ttgaaggcct ttccggtgcc 1039621 ggtgttttcg gcattttcgg cccgacagga agcggtaaat cctctatact cgacgcaatg 1039681 acgcttgctt tatacggaaa ggtggaacgg gcggcgaata atacgcacgg aatcttaaat 1039741 cacgccgaag atacgctgtc tgtgtccttt acctttgcgc ttcagacgaa tcaccaaatc 1039801 tcatacaaag tcgagcgtgt gtttaagaga acggatgaaa tgaaggtaaa aacggcactt 1039861 tgccgcttca tcgaaatcaa ggacgagcat acggtgctgg ctgataaagc cagcgaagtg 1039921 aataaaagag tggaggagct cttagggctg acgatcgacg attttacgag agcggtggtg 1039981 ctgccccaag ggaaatttgc tgaatttctg tctttaaaag gggcagagcg caggcatatg 1040041 cttcagcgtt tatttaattt ggagcaatat ggagacaggc ttgtgaaaaa gctgagacgg 1040101 caggcgcagg aagccaatgc gagaaaaaat gaaatgcttg ctgaacagtc cggtctcggt 1040161 gaggcgagct cagaggcagt ggagcaggct gaaaaggttc tcgaacaagc tgaagcccgg 1040221 ctggaagcga tgaggaagaa ccgtgatcag gcgaaggagc ggtttacaga gcatcaggag 1040281 atatggaatg tccaaaagga aaaatccact tatgaagaag aggaaaaacg tctcgcagaa 1040341 gaacagccgc atatagacag catgcaaaaa cgcctgctgg aagcagaaac agcagcagcc 1040401 cttaagccct atgcggaccg gtacgcagaa gcgatccagc atgaggagca agctgaaaag 1040461 gaacaaacgc tagcccaaaa ggatttagca gaccggacag ctttctttca gcaaaaacat 1040521 gaagagtatg aagcgtggcg ccagcataaa agcgagaaag agcctgagct tttagccaaa 1040581 caggaacagc tttcacgctt gcaggaaatc gaaatcaaac tgagtgaggc caagcaagag 1040641 gaagagcgca aaaaggctga cctccggcag aaagaagagg ctcttcaatc tgtcatgaat 1040701 gaattagaga ccgtaacaga ccgcctgaca cgagggcaaa acagacagac agaattgaag 1040761 cagcagctca aatccctgca ggtgacatcc gatgagcgaa aaagctgcca gcaggccgca 1040821 gagatggcat tgcgcatcag acaaaccgag gaacaaatca aaaaagagaa aaaacgaagt 1040881 gaagaattga acctcgtgct gcagaagatg aatgaagaga agaatacact cgttcaaaag 1040941 acggaagcgg aagaaaacaa catcattcag gcatatgagg cagttcaaac tgtgtaccat 1041001 ttggtgtgcg aaacggaacg ctcattaaca cgtatgacgg aagaggctag aaagagtcaa 1041061 cacacgcttc acttacagcg tgaaaaagca agggtggcac tgctgacaaa agagttagcc 1041121 caaaagctga ctgccggaaa gccttgcccg gtatgcggtt caaccgatca tgatccatct 1041181 gcctcggtac atgaaacgta tgaagccgac agccatcttg aagaggacat caaacggaca 1041241 gatgtgttat tgacggaagc tgcagctctc agccaggaga ttctttcagc caaaattatg 1041301 cttgaagaac agtccgcgcg ctttattgaa cagtgtccgt ttttgcagac aattcaagca 1041361 cagaaccttg aagcggcagc ttccttcgaa catcagccgg tgtatgaagc atttgaaact 1041421 gccaaatttg aatggaaacg aatcaagcag gacattcttt ctgttaagac acgaatggca 1041481 caaatgattg gcgcctatca ggagtcttta aaaaaggccg agcagcttaa tgaaaaaatc 1041541 ggttttgaaa aaagagaagc cgaccgtatt gaaagcatca tcagtgagct tcaatcctca 1041601 atggacagca gtctgaacat gtttaaagaa gcatttcaga atcaatctgt ggacgaagca 1041661 gaaaaatggc agcaagccat tgaagaaaag gaccgggctg cagaagaatg tgaaaaacga 1041721 attgagaaga gtatcgcgtt tcttgctgag catgaagcac aaaaggaaaa actgcgggaa 1041781 tcgggacacc ggcttgagcg ggaaaagctg gagcttcatt atgcggctga acgcatcaag 1041841 agcgtgatag ctgattatga gcacgaactc ggagattatg caaaaggaga ttcgattcaa 1041901 atcaaactcc gctctgtcca gcaggatcta aagctgttaa aggaaaaaga acaatcttta 1041961 tatgaagaac tgcaaagcgc ccaaatgaag ctcaaccaag cgaaaagccg cgcttctgca 1042021 agcgagctca ctcttcaaga ggcgaagggc agattggaaa aagcaaaagc tgcttggctt 1042081 gagcatacaa aaaacacctc cattacccgg actgaggagg ttgaacaaag tctcatccca 1042141 gctgatgaac ttgaaaagat gaaaaccggc atagaccagt ttatggataa actgaagcaa 1042201 aatgctgcaa acttaaaacg agtagcagag atacttgccg gcagagcatt atcagagagc 1042261 gaatggaacg aaaccgttgc agcattacaa gaagctgagg acgcatttgg cgctgctata 1042321 gaggaaaaag gcgcggccgc aaaagcactg gctgtcattc gcgaccatca taaacggttt 1042381 aatgaaattg aagctgaact gaaaaaatgg cagatgcata tcgacaggct ggacaagctg 1042441 caagctgtgt ttaaaggcaa taccttcgtc gaatttttag ctgaggagca gcttgaaagc 1042501 gttgcgaggg acgcctcagc aagactcagt atgctgacaa gacagcgcta tgccatcgaa 1042561 gtagattctg agggcggctt cgtgatgcgg gatgacgcga atggaggcgt acgacgcccg 1042621 gtttccagtt tgtctggagg agagaccttc ctcacctcgc tttcacttgc tcttgcgctg 1042681 tctgcgcaga ttcagcttcg gggggaatac ccgctgcagt tctttttctt agatgaaggc 1042741 ttcggcacac tggatcaaga tctgcttgat acggttgtaa cggccttgga aaaacttcag 1042801 tcagacaacc tggctgtcgg tgtcatcagc catgtgcagg aactgcgtgc acggcttccg 1042861 aaaaagctga tcgtccatcc ggctgaaccg agcggccgcg gtacgcgggt atcacttgag 1042921 ttgatgtaag ggaggagcgg atatggcaaa gcagattgcc ggaatatgtg agctgtgcgg 1042981 ccggagcgat gtccagctga cagagcatca tcttacaccg aaagaggaag gcggaacgtt 1043041 tttgccgaca gcgatgctct gtattccttg tcataaacag attcatgcct tatataccaa 1043101 tcaagagctc gctgtacgtt taaatggaat ggctgaactc agaagcgatc cagagcttgc 1043161 ccggtttgtc aaatggatca gaaaacagcc gcctgagaag ctgatcaaaa ctaagaaatc 1043221 aaatgaacga aaaaagaaaa aatgactaaa aagcagccct ctctttgcag agcggctgct 1043281 tttatccgtt tccaaccata tccggaagca aaagttgttg ttgaaaagta accaaaaagc 1043341 ggtgctcgat gcaccgcttt tttatttgcg cccccgttgg actgctgtgt acataatgga 1043401 tcgctttccg tttgaagccg tccattcaaa acggtctcct gtcccttcgc tgctgtagtt 1043461 gtagtgatgc tgcatcgcgc attgtgcggt gtcatttgaa aagtgataaa aggacacacc 1043521 ctgccccgcc gaagtattcg aaaagactcc tttattataa gaaaagacgc aatcgaatac 1043581 cgataagccg aagctgtgca agtgctgcag aaatgcgaga aaggtttcgt cgtcaagcga 1043641 atccaaaagc gccatgagcg gccgcttgac tgatttctca tagcggatgc gttctccgcc 1043701 ggaaagggag atgttttctg caccgcatgc caaaaccaac ttgtcctgaa agccggcttg 1043761 ctcccacttt cctttatgat ggatccagat tgggctgtgt tggagactgt ccgccagcag 1043821 tatatcgcct tcaccgtttt cgattaagca gatgccgtct tcaatgagga tggtgccgta 1043881 ttcccacttt cgttcctctg tatataacaa ttgtttccgt ttcatccatg ctgtctcctt 1043941 tttcttcatt cctctctttt ctttccaatt caagcctgtc ccatacaact cttttatgga 1044001 caaatcaact atctgcctat agatgcataa acttactaag gtgctgaaag aaacgaaatt 1044061 gttacgaaag aaacgggatt ggagctgatg tcacatgtgt ggaattacgg gttgggtcga 1044121 ttttaaaaag cagctcgtcc aggaaaaaca aacgatggac agaatgacag acactctttc 1044181 caaacgaggg cctgatgatt caaacgtttg gggggagcac catgttttat tcggacataa 1044241 aagacttgcg gttgttgata ttgaaggcgg acgccagccg atggcgtgta cctataaagg 1044301 cgatacgtac accattattt acaatggcga gctttataac acggaagatt tgcgcaaaga 1044361 attgcgggcg cggggccatc aattcgagcg tacgtcagat accgaggtgc ttctgcacag 1044421 ctacatcgag tggcaggaag actgtgtcga ccatctcaat ggcatattcg ctttcgctgt 1044481 gtgggatgaa aagcgtaatc tgttgtttgc cgcgagagac cgtctcggtg taaagccgtt 1044541 tttttacacg aaggaaggct cttcatttct cttcgggtcg gaaatcaaag caatcctcgc 1044601 gcaccctgat ataaaagcgc gagtggacag aacgggactt tctgaaattt tcggtcttgg 1044661 accgtccaga accccgggca ctggcatatt taaaggcata aaagaaatcc gcccggctca 1044721 cgcgctgaca ttttccaaag acggacttaa tatttggcgt tattggaatg ttgaaagcga 1044781 aaaacatacg gacagttttg atgacacggt tgccaatgtc agatcgttat ttcaggacgc 1044841 ggtgacgcgg cagcttgtgt cggatgtgcc tgtttgcaca ttcctatcag gcggtctgga 1044901 ctcaagcgcg attacagcga ttgcggcggg ccattttgaa aaggaaggaa aagcaccgct 1044961 tcatacttat tcgattgatt acgaagagaa cgataaatat tttcaagcaa gcgcttttca 1045021 gccgaatgat gacggaccat ggattgaaaa aatgacagag gctttcggca caacgcacca 1045081 caaatgcgtc atcagccaaa aagacctcgt tgatcatttg gaggaagctg tactggtcaa 1045141 agacttgccg ggaatggcag atgtcgactc atccctgctg tggttttgcc gggaaatcaa 1045201 aaaggacttt gtcgtcagcc tatcgggaga atgcgcggat gagattttcg gcgggtaccc 1045261 gtggttccat acggcagatg ttgagtctgg ctttccatgg atgagatcaa cggaggagcg 1045321 gatcaagctg ctttctgact catggcagaa aaaattgaat ctgaaagaat acgtaaatgc 1045381 caaatatgaa gaaaccttgg cagaaacgcc attattagac ggagaaacgg gtgtggataa 1045441 agcaagaaga cagctgttct atttaaatat gctttggttt atgacgaacc ttttggatcg 1045501 gaaggatcgc atgagcatgg gggcgagcct ggaagtgcgg gtgccgttcg ccgatcaccg 1045561 gcttgtggaa tatgtttgga atattccgtg ggaaatgaaa atgcatgata atcgggaaaa 1045621 aggcattttg cgcaaagcgc ttgagggcat tttgcctgat gacattttgt atcgcaaaaa 1045681 aagcccatat ccgaaaacac atcatccgga atatacaaaa ggcgtcagcg agtggctgaa 1045741 aacgatcaga agccaaaagg actccgtgct ccatacctta ctggacagaa aacaattaga 1045801 tcagctttta gaaacggaag gctcctcctt caaggtcccg tggttcgggc agctcatgaa 1045861 ggggcctcag ctgatcgccc atcttgctca aattcataca tggtttgaag cgtatcgcat 1045921 tgatattgac gagaggtagg ttcaatacaa atgtgattaa aagccagaga tgtatagatt 1045981 taaataagaa ggatagatga gcagggaaat atatgctcta tctatccttt tttgtacaac 1046041 agcactatcg aattgccccc gcattccttc aataagaatg aataggtttt aatgttctgc 1046101 cgataaaact agctgatacc gggcttaact ttaattccct agcccataca gaaagttgac 1046161 caatatggtg aatttcgtga gcgatgatat ggtgtaatat ttcatctcgc gtatataaaa 1046221 cacctgtctc ccaaggaacg cttacaagtt catcttttat ttgatctgaa tgtgtttgta 1046281 aaacatcaat tatttcagtt cggaatgtat ttgagagaga tttcacttta ttgagtgttt 1046341 gataatcagc gaactgaaca gcgatatctt cttttccttg gatagcacga atccaactat 1046401 attccacatc aataatatga aaaagggtat ataaaatatt ctctactccg ccaagacgat 1046461 ttttaagtaa ttcttcagtg gttagttgat gacaccaagt aaaccattga tctctaacct 1046521 gccagttata ttcaaaaaat ttcatcacta aactcactcc aatactatca tgtatcataa 1046581 caattagccc ttttttccgt gattcctcta ttaatgaagt gatgattgag aaatgtttac 1046641 attctacctg ttgtatggca ttaaaaataa taatgcatat ctcgtcgatg atgctgtgcg 1046701 tcttgttact tttacaaagt aagaatcggc attttcttca tatacaatta ggaaaaaaca 1046761 tactagactt gaagaagcag tgatacatag gagtgagaaa atgaaagaga taaaagaagc 1046821 ttaccagcaa tgcggacaga ttgttggcga atacgcgcca gcctgtttca aagcattatc 1046881 atatctcccg ctaaagcaaa gacaagcctc ttgggcagta ttgtcgtttt gccacacggc 1046941 ggccagtgca gacgaaaagg tattgcccgc atttgaagct aaagctgatc atgtttacca 1047001 aaggacaaat aacggtaaac aacatctatg gaaggctttt gatcatgcgt atcggacctt 1047061 tacattggaa agcgaacctt ttcgggagtt tattgccgca caaaaagaag acgccaagcc 1047121 gtatgatgac cttgatgaac tgctcatgta cgcatatcgg acgggcggtg ctgccggatt 1047181 gatgctgctg ccgatactga cacgccgaaa acaagatcag ctcaaacaag cagccgtctc 1047241 tctcggcttg gccatacagc tggttcgctt cttaagtgat cttggcacag atcagcaaaa 1047301 aaaccgcatt ccccgtcagg taatgcagca attcggctat acagaggctg atctccaaaa 1047361 aggcaccgta aataaagcgt tcacaatgac gtgggagtat atcgcttttg aagcagaagc 1047421 ctaccttgaa gagtgtcagg atgccttgcc gctatttccg cagtattctc aaaaaacggt 1047481 gaaagccgct cttcatttgc accgggctgt tttagaaaaa atccgggcga agcagcacga 1047541 tgtatttcaa tatcacttcg ctctcacaga gaccgaagtg aagcagattc tgtctgatat 1047601 ctaaaaaaca cccggccttg attgagccgg gtgttacgcc ataccttttt gaatccagat 1047661 acgtgagcgc catcttctgt acattaagat tccccggacc cattcatccg cgataaaaga 1047721 aatccaaatg ccggcaagac cgaaaccgag gtggatgccg aaaagataag caagcgggag 1047781 gccaatgccc cacattgaaa tcattgccat gtaaaccggg aatttcgcat cccccgcggc 1047841 ccgcagagag ttaatgataa tgacattaaa cgagcggcct ggttcaagga taatggtcat 1047901 ggcaatcaat aggcttgcag ttgctataat gtcagggctt tgtgtgaaga gtccgatcag 1047961 gtcttttgaa aagatcgtca tcaaaacaga ggtagccgca gcaattccga gtgcccaata 1048021 taagctcttc atgcagcgct cataagcggc atcaaattgt ttgccgccga tataacggcc 1048081 gattaagatt tgtgtaccct ggctgatcgc agtgccgaac agcaaaataa acatcgtaat 1048141 attttgcgta tacacttttg ttgtcaacgc ctgcgcgccc atgatggcga taaaatacgt 1048201 gactatcatt tgcgacaggt tgtatgaaag ctgctctccc gcagaaggaa tgccgatttt 1048261 cagcagcttg cgcaaatgct ctttatgcat atgaaagact tttttcagcg acatcttcag 1048321 ctggatgcgt ttgttgacaa tcacaatcat cgcgattaat ccgatgacgc gggcgataga 1048381 tgtggacatg gccacaccgg caacaccgag aacaggaaag ccgaacaaac cgaaaatcac 1048441 aacaaagttt ccggcaatgt ttaaaatgtt catgccgata gtgacaaaca ttgtatcttt 1048501 tgtgtagccg tagcttttta agatcgcgct gaatgtcatg attaaagcct gaataaagga 1048561 cagacctccg acaacttgta aaaagacttt cgcatcaggc atcagtgcgt ctgataatcc 1048621 catcatatga agcagaggga cagccgcgaa aaagacgacg gcgctgatgg ccaggctgat 1048681 gaagaagttg gcgccgattg acacataagc gacttccatg gcttctttct tttgccgtga 1048741 gcctagaaat tgtgaaatga taacggtcgt tcctgttgcg ataaagctga acatcacgat 1048801 aattaaattt aaaatctggt tgctgacgcc gactgctgcc acgctgttat ccgagtattg 1048861 gctgagcatc agtgtatcgg cattacccat aaacatatat aatgagacct caataaagat 1048921 cggccaagta agcgaaaata atgagaacgt tttgtcagcg ggttttttca aagcagttga 1048981 tttgaagaca gcttgtttca tcgtgtctaa cccctttcgt aaataaaatc aacgttttaa 1049041 agtgtacctc catttcctta taataaaaag ggatagaaac gatacttctt gtaaaaatcc 1049101 gacttaaaaa ggaggatgat tcaaatgcct cgcatcctgt ttacagtccc gccttttccg 1049161 gtatttatcg cagctgggga aggggttttt aaaaaaggag aaacccatgt gaaacgtgta 1049221 ttctccgtgt ttgatctgat atatgtcaaa cagggaacgt tatatataac ggaaaatgaa 1049281 acatcgtttt ctgttgaagg cggcgagtac atcttgcttt ctcccggtct tgaacactac 1049341 gggacgaagg gcagtgatga agcaacctcc tactattggc ttcacttcga tgaacatcga 1049401 tatgaattta cggcaaaggg aggcagcaac tggtctgagc ttcagcagga aaaagggagc 1049461 ttcgaagagc tggcccgcta cggattggcc ttgccgagaa aaggcaaggt gcagcgcccg 1049521 cagtttatgg cgcagcagtt tgaaaagctg atcgattact ccgcggaaaa ctctgatttg 1049581 ccgctcagaa agcaaatttt atttgaggag ctgatgctgc atcttcaaaa agaagcgttc 1049641 caaataccgt ctgcgaaaga gcgggtagcc tgggaggcgg cccggtattt acaggagcac 1049701 tataaggaaa agacgacaat caaggatctg tcgctcgccc ttcactatca tcaggattat 1049761 gtgagccgct gcatgcagca ggtgctcggc gtaactccgg cacaatacac gaaccgggtg 1049821 agaatgacgg aagcgaagcg tcttttatcc tctacaaatg ataaaatggg cgttattgcg 1049881 gaaacggtcg gaatggaaga tccgacatac ttttcaaaac tctttaagca gatagaaggc 1049941 atttcaccaa ttgaataccg gaaaattgtc agccggaaag ttcaataacc agacgaggga 1050001 tgaacatgaa aacaacaatt tacgatgtgg caaaggcggc gggtgtttcg atcacaactg 1050061 tgtcccgtgt gataaacaat acggggagaa tcagcgataa aacacggcag aaggtcatga 1050121 atgtcatgaa tgaaatggca tacacgccca atgtccacgc cgcggcgtta acgggaaaac 1050181 gaacgaatat gatcgctctc gtggcgcctg atatttcaaa tccgttttac ggcgaactgg 1050241 ccaaaagcat tgaggaaaga gcggatgagc tcggttttca aatgttgatt tgcagcaccg 1050301 attacgatcc gaaaaaagaa acaaagtatt tttctgtgct gaaacagaaa aaggtggatg 1050361 gcattatttt tgcaacaggg attgaaagcc atgacagtat gtctgctttg gaggaaatcg 1050421 ccagtgaaca aattccgatt gccatgattt ctcaggataa gccgcttctt ccgatggata 1050481 ttgttgtgat agacgacgtt cgtggcggat atgaggctgc caagcatctt ctgtcactcg 1050541 gccacacgaa catcgcctgc attatcggag acgggtcaac gacaggcgaa aaaaatagaa 1050601 tcaaaggctt ccgtcaggcg atggaggaag cgggcgtgcc cattgatgaa tcacttatca 1050661 tccagacgcg gttttccttg gaaagcggca aggaagaagc gggaaaattg ctcgacagaa 1050721 atgctccgac tgctattttt gccttcaacg acgtattggc ttgtgccgcc atacaagctg 1050781 cgagaataag aggcataaaa gtgccggatg atctttctat cattggtttt gataatacga 1050841 tactcgcaga aatggcggct ccgcccctga caaccgtagc ccagccgata aaagagatgg 1050901 ggcggagcgt catcgaactg ctggcagaag caatagaggg aaaacgaaag gcgaaacaaa 1050961 aaatagtgct cccgcctgag cttgtagtca gacattctac atcaccgctc aacacatgag 1051021 cccgctaatg agcgggtttt ttcattatga cagttgaagc caaaaaaaca tattgcgtgt 1051081 aaaccaaagg cggtgtaaaa tataaccatc ttttgagaaa gcgcttgcgc aaaatggcag 1051141 agcggataga accgctgttt ttttagctgt taagagaaaa cgctttctca aagcgagccc 1051201 gaaatgagat aaaggagagg atgggacgtg gaacatcaag taagatgtgc agtattggga 1051261 ttaggaaggc tcggttatta tcatgcgaaa aatctcgtca ccagtgtgcc gggggcaaag 1051321 ctggtttgtg tcggtgatcc gttaaaaggg agagcggagc aggttgccag agaactcggt 1051381 atcgaaaaat ggtcagagga cccgtatgaa gtgttagaag atcccggcat tgatgctgtc 1051441 attatcgtaa cgccgacaag cacacatggt gatatgatca tcaaagcagc cgagaacggc 1051501 aaacagatct ttgttgaaaa accgctgaca ttaagccttg aggaatcaaa agcagcttct 1051561 gaaaaagtta aggagacagg tgtcatctgc caagtcggct ttatgagacg gttcgatccc 1051621 gcatacgcag atgccaaacg gcggatcgac gctggagaaa tcggcaaacc tatctattat 1051681 aaaggcttta cgcgcgacca aggcgcgcct cccgcagaat ttatcaaaca cagcggtgga 1051741 atttttatcg actgttccat ccatgactat gatattgccc gttatttgct aggggcggaa 1051801 atcacttctg tttcaggaca cggcaggatt ctgaacaatc cgtttatgga gcagtatggc 1051861 gatgtggatc aggcgctgac gtatattgaa tttgactcgg gcgcagcggg ggacgtcgag 1051921 gcaagcagaa cctctccata cggacatgac atccgggcgg aggtgatcgg gacagagggc 1051981 agtattttca tagggacatt gagacatcaa catgtgacca tcctatcggc taaagggagc 1052041 agttttgata tcattccaga ctttcaaact cgttttcatg aagcctactg cttggagctt 1052101 cagcatttcg ccgagtgtgt ccggaatgga aaaacaccga ttgtgactga tattgatgcg 1052161 acgatcaatt tagaagtggg tatcgccgca accaattcct ttcgaaacgg catgccggta 1052221 cagctagatg tgaagcgcgc ttatacaggt atgtaaaagc taagtatgtt gcatttgagg 1052281 ctttccgcaa aaaaagcaag ggcattttag cccttgcttt ctcttttctc atataaatag 1052341 tacatataat cagtaggtac gcctgaatgg tccagctgtc tcagcatggc ggttacgttc 1052401 cctctgtggt aagtgccgtg attgacgaca tgcaggatgg tgtctgcata ggttgattcc 1052461 agtgtaccta gtttcggatg ctgcattgtg aaggtctgtt ctaagtccgt ctggcggctg 1052521 aagaaatcat gatactgtga ctccagctcg gcagcgtgct gtttaatcgc tgccatatta 1052581 ccttgcgcgg actgtaattt gcctgcgctg tctataatct cttggtaggc cactcccgaa 1052641 agaacattca gccaaatgta gtcagccctg cacatatgaa gcagcacgtc gctgacagaa 1052701 ggaaatacgc tctttacttc ttgataggca gtttcctccg gcaggttttc gatatgggta 1052761 aatattttct tgtttgccca agaatgatag tcataaaact gttttgcatc agtcatcagc 1052821 atgccccctt ttctaagaaa ttcgtttttt tcatctgttt ctccttcaat tgcaaaagag 1052881 tgacacccca aaatatcctg ccgctgccca cattaccgct gcagagcatt tgtttacgat 1052941 cagcataagc ctgccgctcg tatctatcgt ctgaaacaac cggcccgcta ttgcaaggct 1053001 gatgaaccaa atccaagaca cagcgatgca ggcggccata aagagccatt tctcaagccc 1053061 cgaatattga agagagctcg tgccgatgac gccgatcgtg tccagaatgg catgcgggtt 1053121 taaaagagaa acagcggccg caaacgcagc ttgctttttt ggtgtgaacg tatgtttctc 1053181 attttggctt gtgttcggac ggatgttcca agtcacccag cccatataaa gcaaaaataa 1053241 aaatccgccg gccatcatga ctgtctcaaa cacaggcagc tcctgcacaa tgacagacac 1053301 gcccgcaacg gctaatacaa ttaacaaggt atcgcagact gaagcactga tgacagctgg 1053361 gagagcccgc caaatatgct tttgcaacgc gccttgctga aaaataaaca cattctgcac 1053421 tcccagcggc aaaattaagc caaacgcgag cacaattccg tgaatgattg cattcatgct 1053481 gaaaaagctc ctttcacatt ttttttcaat cataagagag attgtcacta aagtctccag 1053541 ccatttggtt gggttaggaa ccagccaaat gtataatgtg taaaaaaggg gggcatgacc 1053601 ttgtcgcaat ggcagccaag ccgaaagtcg gatgttccgc tgcatcggca gatcgaacaa 1053661 tatatgaaag acaagattct tcacggagag tgggctgtag ggacgaaaat cccctcacag 1053721 agaacgctgg ccgacatgtt tcaagtcaac cgcagcacag tcacagcagc catagatgaa 1053781 ctcacgtctc aaggcttgtt agagggaaga aaaggcggcg gtacgaaggt tgtaaacagt 1053841 acttggagcg tgctgacggc tgagcctccg cttgattgga gcgattacgt ccgttcgggc 1053901 attcatcgcg ccaattcttc catcattcaa gctattaatc agaacgaacc aagagcggat 1053961 atcatcagat taggaactgg agaactttca ccggatcttg tgcctgctga cacaattgga 1054021 cggatgtttc agcaaatcaa tccgggcgtc ctgtctttag gatatgagca gccgaaagga 1054081 aaccgtcagc tgcgggaggc agtggccgac catttaaaag gaaagaagat ccatgtgtca 1054141 ccgtctgcaa ttttaattgt gtccggtgca cttcaggcac ttcagctcat ctcaattgga 1054201 cttttaaaac gagattctgt cattttgacg gagaagccgt cctaccttca atccttgcat 1054261 gtatttcaat cagctgggat gcggcttcgc ggcttgccga tggatgatga aggggtcaaa 1054321 gcggggcttg tttcttctaa tcgaaaacaa tatggaggac agctgcttta cacgattccg 1054381 tcgtttcata atccgacagg cacagtcatg tcagagcagc gaaggaaaga gatcatcagc 1054441 ctgtcaaaaa aagagcagat gcccatcatt gaggatgatg cgtacggtga tttatggttt 1054501 gaagaaaaac cgccgcagcc gttgaaagca atggatcatg agggcaatat tctgtatctg 1054561 ggcgcgtttt caaaaacggt tagccccggt ctgcgaatcg gctggcttgc cggtccggag 1054621 ccggttattg aaaggctggc ggacattaaa atgcagacag actacggatc aagcggcctg 1054681 tcccagtggg cggctgccga gtggctgtca cagggatatt atgaagagca tctgacttgg 1054741 gtacgcagga agcttaaaga aaggagagac gccgccgttc attttctcga gcggtatgcc 1054801 ggggacattg ccacgtggcg gattcccgca ggcggctttt atatttgggt gacatttcac 1054861 aaaaacctgc ctgtcagccg tttcttttat gaattgctga aacggcaggt gcttgtgaat 1054921 cccggctata tttatgacgg tgaagaccga aacagcatca ggctgtcata ttcctatgca 1054981 tctcttggag atttggaaac tggcattaaa gcggcagctg aaacagcacg ccgcctgatg 1055041 atgtcctagg ctttggttat acgatgacag ctcccagtgc cctggcgaag gcaatcgcgt 1055101 gctcaggtgc gattttgcag cctttcaatt tgtcgaggga gacatgaagc tgttcaaaac 1055161 ggcacgtgct gatgtccatg ttttgaaggg acgtgccggt aaagctggcg ccttccaatt 1055221 cgcatccgtc aaagtgtgtc tgctggagca ccgtatcgct gcattcactt tgcataagag 1055281 cacagtgatc aaatcgaact tgtttcatat ttgagtacga aaatgagctg aaatgtccgt 1055341 ggcattcctc gaatgaaaca ttccgcagcg ttgcttccgc cacattcatt ccaaccattt 1055401 ttgactgctt aactgaagtt ctgtgaatga cagccccgct gaaatcggcg tttgataaat 1055461 cgcatttttc aaagatcaca tcggtcagtt caatatgccg aaaagacaca tcgataaaga 1055521 cgacatttct gaataccgtt ttttcaacac atagtctttc gatatcttcg ccgcagatgg 1055581 tgcaatcttc aaacaaatgc atgctgatta catcatcctg tgtcacggca tcatgaaaat 1055641 ctgcggtttg caggttttcc ggtatgttcg gtttttgaat tgcgatttta ttcatgtgat 1055701 gacatccttt gctgcccgaa aaacagaggc ttccgggttc aatttaatag atcgttaagg 1055761 aaattgatac atatagtaaa tcgtgaagag ccttttcttg gtacagcagc ccgcttgttt 1055821 tgtaagcata aatggaaagc ttcctatacg tcaaggcgtt tacaggccga aaaagccaaa 1055881 gggaacagga ggaatgcgga atggggcatt acatcaaaac cgaggagcat gtgacactgt 1055941 ttgtagagga tatcggacat ggaaggccga tcatcttttt gcacgggtgg ccgttgaatc 1056001 ataagatgtt tgaatatcaa atgaatgagc ttccgaaaag gggatttcgt tttatcggcg 1056061 ttgatttgcg gggatatggg caatctgacc gcccttggga aggctacgat tatgacacga 1056121 tggccgatga tgtgaaagca gtcatttata cgctgcagct tgagaatgcg attcttgccg 1056181 gtttttcaat gggcggcgca attgcaatcc gttatatggc aaggcatgaa ggagccgatg 1056241 ttgataagct gattttactg tctgcggcgg cccccgcgtt tacaaaacgc ccgggttatc 1056301 cgtacgggat gaggaagcag gatattgacg atatgattga attgttcaaa gctgatcggc 1056361 ccaaaacact ggctgattta gggaaacagt tttttgagaa aaaagtgtct ccagagctta 1056421 ggcagtggtt tctcaatctg atgctggagg cttcctccta cgggacgatc cactcgggca 1056481 tcgcattaag agacgaagat ctcagaaagg aacttgctgc aatcaaggtg ccgacgctga 1056541 tcctgcacgg gagaaaggat agaattgcgc cgtttgattt tgcgaaagaa ttgaagcgcg 1056601 gcatcaaaca gtcggaattg gttccgtttg caaacagcgg gcacggagca ttttatgagg 1056661 aaaaagagaa gatcaacagt ttgattgcgc agttctccaa ctcataagaa aaaacccgac 1056721 attgatcggg ttttttatat aattcctctg ttttgcagtg cgttaatgat gagatcagct 1056781 ccatcggaaa tagaggtctg gtcagactca atgatgaaat cgggtgaaag cggcgcttca 1056841 tacggagaat cgatcccggt gaaatgtttg atctctccgt ttcgcgcttt tttataaagc 1056901 ccttttggat cgcgctgttc acaaacatgc agcgggcact tcacataaat ttcgaagaac 1056961 tcacctttag gaaagagcgc tctaaccatg tcccgatcct ctctgaatgg agaaataaaa 1057021 gccgttaaaa tcatttgccc gctgtcgaca aacagcttcg ccacttctcc gatccggcgg 1057081 atgttttcaa tcctgtcacc agtctgaaat ccaagatctt tgtttaagcc gtggcggata 1057141 ttatcaccgt caagcacgta gctctgaatg cccttgcggt aaagcttttc atcgacagca 1057201 ttggccagca ccgattttcc ggagccggac aaacctgtaa accaaaggac gcagcttttg 1057261 tgtccgttta aggactgtct gtcagacttt gagatggcag cgggatgcca aatgatgttc 1057321 ggattgtgtg tcattgcaat tccccgctgt tttgcttgat ggcaacaggc tgttggtgaa 1057381 gtcccttgat cagcacggct gcgacctcag gccggctgaa ttctttaggc ggctttttgc 1057441 cttggcggag aagctctctc acttttgtgc ctgataagtg gatgtggtct ctcgggctgt 1057501 gcggacatgt tttggaggtg cccatgtttc cgcattttcg gcaataaaag ctgtgctcaa 1057561 aaaacagcgg cttgatgccc agctcttcct ctgtgaatga ttgaaaaata ttttgggcgt 1057621 cgtatgttcc atagtagctg ccgacacccg cgtgatcacg gcctacaata aaatgggtac 1057681 agccgtaatt ttttcggacg agcgcatgga aaatcgcttc ccgcggacct gcataacgca 1057741 tggcggcagg gaaaaccgat aacatgacac gatcctttgg ataatagtga ttaagcaaag 1057801 cctggtagct ctccattctg atatcgctgg ggatatcgtc tgactttgtt tctccgacaa 1057861 gtgggtgaag cagcagaccg tcgaccgttt ctaacgctgt tttttgaatg tattcatgcg 1057921 ctctgtgaac agggttcctg gtttgaaagc cgacaatcgt cttccagccg agtttttgaa 1057981 aggccgctct tgtttcagcg ggcgttgcat aaaactgttc gaaagatttg tcaggcaggc 1058041 tgctgaccgt gataggccct ccgatatagt aatccgggcg cgccagcaat ttttttacgc 1058101 ctgggtgggc aggatcgttt gttttaaaaa cagacagtgc ttcttgtgtt ttatcaggct 1058161 ggtatatatc ggtgactgtg atcatgccgt aggtaacacc gtctttcaca agcttgacgt 1058221 gatctccggc agacagctgt cttgctgttt tttctccgac aggcagcgta atcggcaggc 1058281 tccacggcaa gccgtttgcc agcctcatct ctttcacaac ggaatgataa tctttttctc 1058341 ccaaaaaacc tgttaacggg ctgtagccgc cgatcgcaat aagctccaga tcactcagtg 1058401 caagctgatc cagctctgct tggcacgcgc acccttcaaa atggcatgcg ggatcacagc 1058461 ggttgattaa tacccctccg tggggttcgt ttccattcaa cgtgttcaac ctccatttat 1058521 acgtttcctt gttttctttt ctgcacttaa tgaaagtttg acatcagcgc cttaacatca 1058581 tttcgattct cacatcaaga acctgccatc cgctattctt gatgcaggcc gcattctgtt 1058641 ttctcccgtc cggcccatct tccagccctc tcatcgttcg ggtccgggga aggcagtgta 1058701 cacatttcac agcctatgct cggataatgt tgatcgtgca gtttgttata aggcaaattg 1058761 tgcaggcgga tgtacgtcca aacgtcatcc catgtccagt ggataagcgg gcaaattttg 1058821 atgagctcaa acttctggtc caggtttacg tattgaatat gctttctcgt tggtgactga 1058881 tcccggcgca gtcctgaaat ccaagctgtc atgccggaca ggtgcttttt gagcggttcg 1058941 attttccgca attggcagca gaggttcggg ttatgcttcc acagctctcc gccgtacttc 1059001 gtcccctgtt ctgttaagct cagctcgggt tcgagcatct ggattgcaaa tcccggatat 1059061 cgttctttga cggtctcgat cagctcatat gtttcctgaa aatgaagccc ggtatccaaa 1059121 aagatgatgt gtgcgttttt gttgattttt gatattaagt cgagaagcac cattccttct 1059181 gcgccaaagc tgcaggcgta cacaatcttt tctccgtacg ttcggtaagc ccatttcaac 1059241 acatcgagct catcgatcaa ttgatccgtt atctgtttgg acagcatgtc gttccaagtg 1059301 tcatatgtga tggtttcgtt caatgttttc cccccgtttg catctgcttt ttttatctat 1059361 tgatcgagtt ataggcagac tattcatttt ttgcataaag gttcaggttt taggtgccgc 1059421 gcccgcctaa aatgaggtgc ggaaccatta agagcccggc tgaatatgct ttttagcaaa 1059481 atggttttat gcccaaggag aggtagtatg ccgattgcca tttatcaggg gcatcatcat 1059541 tcgcttgccc cggcggacat taacatcgtc attgatgtca tcagagcctt tacggtcgcc 1059601 cattatgcgt ttatcggcgg ggcgaaagag attttgttgg tccggacagc tgatgaagcc 1059661 tttgcgctga aagacaccta tccggattat gttttgacgg gagaggaaaa gggggtcggt 1059721 atcagcggat ttgatttaga taattctcca aaacgtatgg ctgggcagaa tatgacggat 1059781 aaaagcctga tccagaaaac aacaaacggc gtcacagcag cattgggggc gctgaacgca 1059841 aagcatctgt tcgtaactgg attttccaat gccaaaacaa cggcacagca tgtgaaaaag 1059901 ctcgtcgcaa acgattgtgt cataaacata gtggcttccc atccatccgg tgatgacgat 1059961 atggcatgtg cggagtatat caaaggcatc attgaaggga caaatgtggt aacggctgcg 1060021 gaggcgattg aaagaataaa aggctcttct gttgcggaga agttttttga ctgccgccag 1060081 ccattgtttg attcggaaga catcgtttac tgtacaaaag aactgacggg cgatttcgtg 1060141 atgaaagtga aacaagatgg agaagttcca acgatagaga gggtcataat atgaatgatt 1060201 tttcactaga attgccagtg agaacaaaca agccgagaga aaccgggcag tccattttaa 1060261 ttgataacgg ctatcccttg caatttttca aagatgcgat agccggagcg tccgactata 1060321 ttgattttgt gaaattcggc tggggcacat cattacttac gaaagatctt gaagaaaaaa 1060381 tcagcacact gaaagaacat gacattacat ttttctttgg cggcacactg tttgaaaagt 1060441 acgtaagcca gaaaaaagtg aatgaatttc atcggtactg cacctatttc ggctgtgaat 1060501 atattgagat ttcaaacggt acgctcccga tgacaaataa agagaaagcg gcttacattg 1060561 ccgatttttc tgatgaattt cttgtgctca gtgaggtggg cagcaaggat gcggaattag 1060621 caagccggca aagctctgag gaatggcttg aatatatcgt tgaggatatg gaagcgggcg 1060681 cggaaaaagt gattacagaa gccagagaaa gcggaacggg agggatctgt tccagcagcg 1060741 gcgatgtcag gtttcaaatt gttgacgaca tcatttcctc ggatattgat atcaacaggc 1060801 tgatttttga agcgcctaac aaaacgcttc agcaagggtt tattcaaaaa atcgggccga 1060861 atgtgaatct tgccaatatt ccatttcatg atgccatcgc gttggaaacg ctgcgtttag 1060921 ggctaagatc cgataccttt tttctgtaaa atagcggctg cggggctctc gtcgtgaaga 1060981 gagcctctgc ctattatttt ttatggcggt acataggcgt gagataggga agtgaggtca 1061041 ggcggatgtt gtagatgaag tcgatgactc ttgtcgatat cacctggcat atgagggctt 1061101 gaatgacgat gccccagtca ataatagacg cggtgaccat aaaaatgatg caattcatga 1061161 tgagcaggat cgttccagga ttcccgccgc ggtagataga aatcatcaga gcaagggctc 1061221 cgaatcctcc gttcgaaatt ttatatttgt ataaaagtcc gattccgagt cccaataaca 1061281 ctgcgccgct tgccagatca agccacaggt tagatgtgat atcaggaaaa actgcatcaa 1061341 agatcaatac cgagacagag gtgacggtga tagaagcgag ggtgccggtg aatgttctca 1061401 tctccagcca ttttaaagcg gtaaaaagca ttgatacatt cacagcccac actgaaaatc 1061461 cgtgggggat ttgaaacaga taatgcaata gcaccgcaat acctgctgca ccgcctgtcg 1061521 gaatatcatg cggaaataaa aacaaggaca tgccgagtcc ttgtagtacg ccgcctacga 1061581 caatcataaa cgtaagtttt gctttcatca gcagttcagc cattaagtca tttgctcctt 1061641 tatgaaaaga cttgtccgct gttttcattt tatgaggctg tccattattt atgtctcaaa 1061701 ataaagaaat ggcccagctt aataggctga gccatcccac ttgtagcgat tgacgatctc 1061761 catattgatc tctgtgccaa tgccttttcc tttcgggatg tggaccattc cttttgaagg 1061821 ctgcaggctg acgagatctg taaaaggatt ctccatgacg tcccactcga tcggttcaat 1061881 gtgatcgttc ttcattttag accatggggg cagacaggct tgtgcaaata aagcatagag 1061941 ccgtgagagc gatccgtcat atgcatgggc ggatgctctg acgccgaaat aacgcgcgag 1062001 ctggaggcag tcccgaaact catcaattcc gttgacatgc atgacatcgg gctgaatgat 1062061 atccaaacag cgctgtgaaa ggagaggcac atattgcgcc gggcctttca tgttttctcc 1062121 gccggcaaca ggaacagaca aacggcttcg aagcatagcg taatcctgcg gctgatcaaa 1062181 gggcaaaggc tcctcaagcc agccaatgtt cgtccattcg gagaaatagc gctcccattt 1062241 aaaagccgca gcggcatcgt agctttggtt tgcgtccaga atcatcgtaa tggagctgcc 1062301 tgctgtatgc tgcagcgcat tgatgtgccg gacatcctcc ttgaatgaag tcccgccaat 1062361 tttgactttg atttgctcaa aacctttttt caactgggct tcaacattgg agactgagcg 1062421 gctgatccat tgcggggagt ctgagtacga ttgaaaagac gcgtacacag gaatctcctc 1062481 tctgtatcgc ccgccccata attcgcaaac cgaacaatcc gcagctttgg ctgcaatctc 1062541 tgtcagcgcc atgcttacag cggaggccgc ccgctggtgc catttttgaa tcgtgcgcac 1062601 taatgacagg cggctgccag cctgttttcc taatagaaat gggatgatcc gcttcgtaaa 1062661 accgacatgg agagcaggga gccaatcaac gcattctccc cagccgtcta tcccgctttc 1062721 ggtgataatc ctgatgagat aacaagtccg atatcgttta aacccattgg catctccgta 1062781 tggcttttct aatcgatgaa atagcggaaa ggtttcaatc cgtacaattt tcacactggg 1062841 tgctaccttt cctcagcggg ctggagccga ttgccagcca ttttagggtc ttctttttct 1062901 tttgtttctt cattgttttg cttcacatgg atgagcatca tcacaagaat cccgacaacg 1062961 agagtcaatc ccgcgatgct taaaaacatg ccgggtctgg accattgcat caggcggccg 1063021 aaaatcggag gaccgatcgc tacccctaag aaacgtacag agccgtacag cgaggtgaca 1063081 aatccccgtc tttctttgcc gacagccccg gtaatgaaac tgttcacaca aggaaggaca 1063141 agacctgagc ctatactgct cagtacaaga acactgataa aaaggacaag attttcaatg 1063201 aatgacagtg ccgcgtagga tacggtcatg aacgccaatc caagtacgat cagctttttc 1063261 attaacgatt gcttttgccc gattttgctt cctgttgtat aggacgtcac acacataacc 1063321 aaaagcggga tcgctaaaat taagcctttt ttcacgccgt cggtgtcgta tgttttttca 1063381 agaacatctg agagataaaa caggatgccg aataaagtaa acaaacaggt cgcaccggct 1063441 aaataagcgg taaacagcca tctgccttca tgtttaaaga cacttaacag cccttttgca 1063501 tattgtccga ttggtggcgg ttctttttcc tttttctttt ctttaataaa aatccaagtc 1063561 agtacgatcg aaatgataca aaacacagga aaggcaaaaa acgcgccata ccagacaagc 1063621 agggcgatca gcgagccaat gatcggcgat agcactttcc ccatgccgtt tgaagcttca 1063681 acaaggccga gcaccttgct ctcctgggcg cctttaaaca gatctcccgt cagtgccatg 1063741 gcaattgggc cggttccggc tgccccgatt ccctgtaacg ctcgtcctgc catgacccaa 1063801 ggataggcat tgtcaaaaaa acctgccgca aacccggcta acaaaccgcc ggcaccatac 1063861 aaaattaagc agggaataat gatgactttc cttgagaatc ggtctgcgag ataaccgaca 1063921 atcggaatcg caaatgctgc aatcaaggaa aatactgtga tcacgagact gacttgaaat 1063981 tgtgataaat gaagttcaga tttcattttt ggcaaaatcg gaataagcat cgagtttcct 1064041 agggttaata ttaaagggat tgaaccgatt gccacaatcg tcattccgtt attttgtttt 1064101 gatgattcca tctcagagca cactcctttt cttctgctta gaatgtccct gatggcttcg 1064161 tttattcagc gatcagacag caaaaaaccg aacagaagat acctgttcgg gaaaaaagag 1064221 ggttaaccga gagcctgtga aatcaaagca tataagtgtc cattttgaat aggcgctttt 1064281 ttctgataga acaaaatcgg aggttcatca tctttatgaa atcccatttc tatcaggctg 1064341 tcatgcagag acgtgtgttc actcggtata tcgattcgca tcggcccttg tttgccggcc 1064401 gccagccttg taattatctg tgctgcaaca tctgatgatg gagcgatgat agggccgaat 1064461 ttcaaattgg ccggtgtctg tacagaaagt ccgtagccaa tgagctgtcc gtcctgattt 1064521 ctggcgatga tacattcgca tgaagcagaa ataagctgct gcaaaaggtt tgatcgatct 1064581 ccgccaaagg cagccagatc cgccgcggtt aagtcgtgaa agtcttgttc tctaaaggat 1064641 gtcagttcag catcaagctt ttttgtataa ggttgaaaac tgtgacagct gtactttcgc 1064701 actgaacctg ccgtatgaaa acctgctttt tcataaagcg gcaaaccttc ttttgtggcg 1064761 caaagcctga tggcggtgtt ttcatccgtt tgggtaatac aggcgtttac catacgccgg 1064821 ccaagaccga gccgttgata ttccttgtca acgataacaa ggccgataga agtaagacgg 1064881 ccaaacaaaa acaagccgat gcaggaaata atatcaccgc tgacattttg ataaccgaaa 1064941 aagcgtccct gctgaacaag cagtttcagc tcttgttcgc cataatccgg ccacccggct 1065001 tgcccgcaaa gccgcaataa gccggaaacg tgttcttcat gaagcttaat cagttcatct 1065061 actacgtcca taagatcacc tgcttgttct aagtgttttg tacatgacaa tatgattgcc 1065121 aatgccggga atgtcaaatg gttcgccaag ttccttccag ccaagcttgg catagtagcc 1065181 cttgacatgg tgtcttgcgt tgcaccatac cgcctgaacg ccgctctccg ccagtttgtg 1065241 ctccgcgtgt ttgatcagcg tgcttccagc tttttgatcg cgatatccct cgagcgttgc 1065301 catgcctctc agccgatacg cagaggcttc cgttaataaa ggctgacttt gcggggaaaa 1065361 agaagcgatg ctgatcagcg ttccatcata aaacacgccg agatgaaagg agccttctgc 1065421 gtgatcctct ttatatttgc attgttcgat ggattgatgg ggacgcagaa tgcgatgccg 1065481 gatttcatat gtatcttcca cggaaatggt tttgacttcg agcataatgt tcctcctcat 1065541 gattgttttt ctatatcgta acacgaatct cgttgaaaaa gactgcccga ttcgatcagg 1065601 cagtcttttg gaaattaatg caaaaagata ttttggcgct gctcatcttt ttgctgaata 1065661 tatgatgtga gctcagcggt taagtcagat ctgaggaaag gcgttatcaa gtagatgccg 1065721 ttaaacagct cgcatgccgt atccagcagg gagcgtgcaa ttgcaaggcc ttccgccttt 1065781 tgcttttctt tatcttcacc ggcatgggcc attttttcgc gaatcgtatc agacagctta 1065841 atgccgggaa tttcattatg gatgaattcg gcattccggc tgcttgtcag cggcatgatg 1065901 ccgatataga tcggcgtctt cagatgtttt gtttcgttat ggatatcgac aagctgctgc 1065961 tcggaataga caggctgaga aacaaaataa tctgcgccgc aatctatttt tttctcaagc 1066021 cgttttaccg ctttatccag atggcggacg ttaggattaa atgcggcggc aactgagaaa 1066081 ttcgttttct tgccgagcgg ttttccagac agagacagac cttcattgaa ttgtttgatc 1066141 agcctgatta aatcaaaaga tgttaaatca tatacagacg tcgccccagg aaaatccccg 1066201 attttagaag ggtcacctgt aatagcaagc acgtcattca gccctaacgt atcaaggccc 1066261 attaaatgtg actgtaagcc gataatgtta cggtcacggc acgtaatatg gacaagggaa 1066321 cgcatatcga gctgctgctt gacaagggcg ccgcaggcaa cattgctgat ccgcggggtc 1066381 gccaaagaat tgtcggcgag tgtcagggca tcgattcccg cttcttttaa ttcagcagca 1066441 gcggacagaa atttgtcaaa gcttagtttt ttcggcgggt ccagctctac gataatagag 1066501 cgttttttcg ctgcgatctc atccaggccg ggctcggttc gctcgtgatg aacagaaatg 1066561 aattctttcg cccgggtttt gacttctttt tccgtaatcg gagccagccc gccaaccgct 1066621 tccgccatcg ccctgatgtg attcggcgtt gtgccgcagc agccgccgat aatccgcgca 1066681 ccttgcttac ggaattctga cgcgctgttt tgaaaatacg tgtcgtctgt ttcatagacg 1066741 agccgtccct cttcaagcga aggaagactg ctgttcggat aaacggataa gaatacgtca 1066801 tcaaaaatcg gcacttcgct tagcgcttca atcatgtgat aagggccgag gcggcagtta 1066861 atgccgacaa tatcagctcc gagatccgca atcgagcgca atgcgtcaga aagcggcgtt 1066921 ccgtcctgca atacgccttg ctcgtgcatg gagacattga gcataatcgg aagatcagtc 1066981 tctttgcgcg cgattttcag cacttcacgg gcttcttcca aatcataata tgtttctaac 1067041 agcaagccat ccggctcttc atgcagcagc agatacagct gctcgcggaa gctgcgctta 1067101 atttcgtcaa gactgtatgc gtttttatta aatgtgcgta tgccgcccat cgttccaagc 1067161 acgtatgcat cgcctgctga agcccgcgcg atctttacgg cctcctgatt catttttttg 1067221 atgtcatcct caagcccgtg tctggataat ttaatatagt tggctccgta cgtattcgtt 1067281 tgaataatgt tggctcccgc ttcaacgtac gctttatgta tgcgctgaat ttcctccggc 1067341 tttgaaatat tgagctcctc aaaacacctg tcaatgccat aggagtagag gagcgtcccc 1067401 atggcgccgt caccgattaa cacctgtctt tgcaaatctt ctaaaagtcc cattgtctgc 1067461 ctcctttatt cacatcagca aggaaaaaag agaaataaaa aaagtcctct taagaagaag 1067521 actttgtcag tgattttgtc tcttcttatc ttccaagctg ttcgagcttg ctggatttag 1067581 caccttggtc atggctgatc gccattacac cggttgctga agcttcgtcg ggccagtccc 1067641 tctgcttctc ttgataagaa cggatatgaa attttcgtgt caggaagtgc caaaagatat 1067701 ctggcgtttt tccctttctc caaatttacc gaaaataaag acaataatca ataggaatca 1067761 gaaaatttat ctgaaattta taaattgaac gtcaattggc agatctgctc cccgtacagc 1067821 tgagataatc tgctgcaggt catctttgtt ttttccggtg acacgcactt gatcatcctg 1067881 cacctgagac tttactttca gtccggagtt tttgatgatc gtattgattt tttttgcgtt 1067941 gtccttgtca atgccttgaa caagctttgc acgctggcgc accgttccgc ctgacgcgtt 1068001 ttcaaccttg ccgtaatcaa tgttttttgt cggtacgttt cgtttaatca atttgctgac 1068061 cagcacatct ttcagctggc ttaatttgaa ttcgtcatcg gaaacgagga ccagctcctc 1068121 tttatctaaa gaaatgtcgc ttttgctgcc tttaaagtca tatcgggtac tgatttcctt 1068181 cagtgcgatt tggattgcgt tttgcacttc aggcaattcc accttggata caatatcaaa 1068241 tgaactttct tttgccatat gaaaacctcc ataacattta acttatgtgt tgattatagt 1068301 agaataaaga gaaacttcca acagaacaaa gaatcaattt gtgatgattg gaaaaaatgt 1068361 taacaaaatc cgcagagaat aagcggaaca ggaaggacga tagcatgaga ccagggcagc 1068421 aattaacctt gagtatagat caccaaaccg acttcggtta ctttttaacc gatggggaag 1068481 atacgattct cttacataac agtgaaatga ctgaggatat cgaggacaga gacgaagtag 1068541 aagtctttat atacgtagac cagcaggaaa ggcttgcggc cacgatgaaa attccgatca 1068601 tcagcgcgga tgaatatggc tgggttgaag tggtggataa agtggaagat atgggcgttt 1068661 tcgttgatgt cggtttatcg aaggacgcac tagtcgcaac tgagcatttg ccgccgtacg 1068721 aagatgtctg gccgcaaaaa ggggacaaac tttactgtat gctgaaggtg acgaaccggg 1068781 ggcgcatgtt tgcgaaacca gcgccggaag atatcatcag cgaactgttt accgacgctt 1068841 cagaagatct gatgaataaa gagctgacag gtacggtgta caggctgatc gcatcgggtt 1068901 cattcgtgat cacggatgac ggtatccgct gttttattca cccgtcagaa agaaaagagg 1068961 agccaagact gggttcaaga gtcacaggcc gggtgattca agtgaaagaa gacggttcag 1069021 tcaacttgtc gctgcttccg agaaaacagg atgcaatgtc agttgatgct gagtgcattc 1069081 taacgtatat gagaatgaga aacggtgcca tgccgtacag tgacaaaagc cagcctgacg 1069141 atatcagaga acgttttaat atgagcaaag ccgcctttaa acgcgcgctg ggccatttga 1069201 tgaaaaacgg aaaagtgtat caggaaaatg gatggacata cgagaaaaaa tagcatgaaa 1069261 acggctcgcc tgcagcagac tgcggagcga gccgtttttt tatgtctagt ttaattcatc 1069321 aaccagcggc caactatatc atattaattt gccaaaatcg tgttcaaata tttgttttaa 1069381 gggaaaacat aataaagaag aaagagcgga ggaacatgcc atggtactag atcaaacaaa 1069441 aaaattactc atcgtcatca tcggcgcttt actcaatgct gccgggctga acttattttt 1069501 gatacctgca gatgtatatg ccagcggatt tacaggtgtt gcccagcttt tatcaagcgt 1069561 cgttgatcaa tatgccccct tttacatatc gacgggaacg ctcttgttcc tcttaaacat 1069621 tccggtcggt attttaggat ggctgaaggt cggcaaatcg tttacagtgt acagcatttt 1069681 aagtgtcgca ctcactactc tgtttatggg gatcctgccg gaaacaagcc tgtcacatga 1069741 cattttgctg aacgcggtgt tcggcggcgt catttccgca gtcggtatcg gcttaacatt 1069801 aaaatacgga gcttcgacag gcgggcttga tatcgtcgcc atggtacttg caaagtggaa 1069861 ggataaaccc gtcggcacgt atttcttcat tctgaacggg attatcatct tgacggcagg 1069921 attattgcaa ggttgggaga aagcattata taccctggtt acactatatg tgacaacgag 1069981 ggtgatcgac gccattcaca ctcgccacat gaagcttacg gcaatgattg tgacgaaaaa 1070041 agcggacgaa atcaaggaag ccatttacgg aaaaatggtg cgcggcatca caactgttcc 1070101 ggcaaaagga gcatttacga acgaacagaa agaaatgatg attatcgtca tcacgaggta 1070161 tgaactgtac gatttagaaa agatcgtcaa agaagttgat ccaaaagcat ttacgaacat 1070221 cgttcaaacg acagggattt ttggtttctt tagaaaagac tgacgaaagc aggtggaagt 1070281 cgtgaaacgg ctgcttgtga tgctcctccc cgtgctgctt ttgataggct gcgggaaaga 1070341 tgagcagaca gaacccgata aggaggtatc aggcggaatg gagaatcaag aggttgtttt 1070401 atctattgac gcaattcagg agcctgaaca aatcaagttt aacatgtcgc tgaagaacca 1070461 aagcgaacgt gctattgagt ttcaattcag cacagggcaa aaatttgaac ttgtcgtgta 1070521 tgattctgag cacaaagaaa gataccgtta ttcgaaagaa aaaatgttta cgcaggcttt 1070581 tcaaaacctg acgcttgaat ctggagaaac atatgatttc tctgatgtgt ggaaggaagt 1070641 ccctgagccc ggaacctatg aggtaaaggt gacatttaag ggcagggcgg aaaatctcaa 1070701 gcaggttcag gctgttcagc agtttgaagt caaataagag gctatggcga gtcgccatag 1070761 ccttttttta ttgcagtttg tccagctgat tttgaaattg atgcaactgt tgacgttccg 1070821 catctgtcga attggcatac gcagaagata cagcattttt ggctctcaga atcgcttgct 1070881 cctgatcgcc ttcctcaaag ccgtttgtca ccatgaccgc ctgttgaaca aatgattttg 1070941 cctgctgaaa cagttcattt ctcatttaat attcatactg cctttcagcc gagtctcgtg 1071001 ccgcggcatg ctggtgagct tcttctaaag tagaccgata tggaaatctt gcggcgtgta 1071061 gcccgatgga gtctttaccc tgctgaataa accttctgga tttgcttcgt ttacccattt 1071121 tgagactgcc cccttccata ctttgacgag atgagtcgtc ttcaatagta tggtggggta 1071181 aagtaaggtt tatgagtggg aaaaattaat acggaccttc tttaaagtga gaaatattct 1071241 ttcaaaaacc ttgccacgcc gtcctcttca tttgtggccg tagttcggtt ggcaatctgc 1071301 ttgaccgcgt caattccatt tcccattgca acgccgcagc ctgcaaattc aagcatttcc 1071361 aaatcgttat cctcatctcc aaaagcaatg atccgctccc tcggcacgcc gtaataatcg 1071421 ctgattttct gcaggccgac cgctttattc atgccgcttt tgataatttc aatgacatgc 1071481 caaggagcgg cccatcttct atggtcgatc acctcggcat gcacatccga taaatatgag 1071541 cgtattgccg gcacatcctc ttcctttgca tgtatgagta cggacgtcac atcttcaccg 1071601 agattttccc gcaagtctcc gaccgttaca tttgttgtgt tcatgttaaa ggcatctatc 1071661 aggtgctcat catggtaatg aaagtatacg tcgtcaatca cttcagcaag cacgttatgt 1071721 acgttgtagc tctcgctgat atccacgagc tgtttgacaa catcaagcgg cagtgacgta 1071781 tgataccgtc cccagctgtc gtcttgcgga tgatggacaa atgctccgtt aaaattgaca 1071841 attggcgttg tcagctccat ctgctggtag tacatggaac ttgaacgata cggacggcct 1071901 gttgagatgc agacataatg cccgtcatct tttaggcgct gtatcgtatg aagggtgttt 1071961 tcagatatgg ttttatcatc ctttaataat gttccatcta aatctaatgc gattaaatag 1072021 ggttttgtct ccatgaaaag ctcctttaac cttagatttt gcttgttttg ccttacttac 1072081 agtgtagctt tttaccatct ttattgtcta catgttacac ttatgattat ggttatccta 1072141 aggaggggca cattgtgata caaattgaga atcaaaccgt ttccggtatt ccgtttttac 1072201 atattgtaaa ggaagagaac aggcaccgcg ctgttcctct cgtgatcttt atacatggtt 1072261 ttacaagcgc gaaggaacac aaccttcata ttgcttatct gcttgcggag aagggtttta 1072321 gagccgttct gccggaggct ttgcaccatg gggaacgggg agaagaaatg gctgttgaag 1072381 agctggcggg gcatttttgg gatatcgtcc tcaacgagat tgaagagatc ggcgtactta 1072441 aaaaccattt tgaaaaagag ggcctgatag acggcggccg catcggtctc gcaggcacgt 1072501 caatgggcgg catcacaacg cttggcgctt tgactgcata tgattggata aaagccggcg 1072561 tcagcctgat gggaagcccg aattacgtgg agctgtttca gcagcagatt gaccatattc 1072621 aatctcaggg cattgaaatc gatgtgccgg aagagaaggt acagcagctg atgaaacgtc 1072681 tcgagttgcg ggatctcagc cttcagccgg agaaactgca acagcgcccg cttttatttt 1072741 ggcacggcgc aaaagataaa gttgtgcctt acgcgccgac ccggaaattt tatgacacga 1072801 ttaaatccca ttacagcgag cagccggaac gcctgcaatt tatcggagat gaaaacgctg 1072861 accataaagt cccgcgggca gctgtgttaa aaacgattga atggtttgaa acgtacttat 1072921 aaagcactaa gttattaaca agagctgaat ttacgttata ctgtagaaaa aaggagtgag 1072981 ggaacgtgga agaagcatta aaagaaaaca tcatgggcgc cctggaacag gttgtcgatc 1073041 ctgagcttgg cgttgatatc gtgaacctcg gcttggtata tgacgttgat atggatgaag 1073101 atggcttgac gcacatcacc atgacgctaa catcaatggg atgcccttta gcgccgatta 1073161 tcgtggatga ggtgaaaaaa gcattagcgg accttcctga agtgaaagac acagaggttc 1073221 acattgtatg gaatccgcct tggactaggg ataaaatgtc cagatacgca aaaattgcgc 1073281 ttggcattca ataaaacaaa aaaggacagc ctgacatgtg aggctgtcct tttttacagc 1073341 tgaaaggagt gaaaggaaat gatgtacctg ctggcagttt tatgcccgcc gcttgctgtt 1073401 ttgttttcgg gaaaaccgtt tcaggccttg ctgaatctca tattgacctg tatcttttgg 1073461 ctgccgggcg cgattcacgc ctgctttatc gtcgccgacc gccgtgccga aaaacgggca 1073521 agaagataat ttggaaaaat gaggacgcag tcatggtata atggtcataa aaacagcagg 1073581 gagagcacta tgaaaaagaa attgcttgca ttcgcgcttt gtactggcgc gtatgcggcc 1073641 ctgtttgcgt actctgtgaa ctcagagcaa aaaacagcca caagcgagat gacggatgtc 1073701 agccgcctga tgcctgtaaa aataaagcag acagtgaaag ggcaggaaga ggaaatgctc 1073761 attgacacag tcaaagaggc aaatcgaaaa aacataaaaa tttcaatcgc cggggcccag 1073821 cactccatgg gcggccatac atattatgag gacggcatcg ttctcgacat gacgggctac 1073881 aacaaaatcc tgtcactcga tcaagagaag aaaaccatca gggtgcaaag cggtgcaacg 1073941 tggaatgata tccagaaata cgtgaatcca tacggactcg cggtaaaagt catgcagtca 1074001 caaaacattt ttacaatcgg cggatctctc agcgcaaatg cacacggacg tgatattcgc 1074061 tacggctcgc taattgatac agtcaaatca ttccggcttt taaaagctga cgggatgatt 1074121 atcactgtca ctccaaaaga tgatttgttt acggcggtca tcggagggta cggccttttt 1074181 ggcgtgattc ttgatgtaac gcttgagctg acagatgatg agctgtatgt catgaagaca 1074241 gaaaaaatga attacagcac atactcagac tatttttcaa agcatgtaaa aggaaatcca 1074301 gatgtccgaa tgcatctggc gcgaatttca acagcgaaaa aaggatttct gaaagacatg 1074361 tatgtcacga attacgtatt ggctaatcat caggatcagc tgtcctcata cagcgaactt 1074421 aaagaagacg agtatacggg agccacaaag tttgcactcg gcttgtcaag acggtatgaa 1074481 tgggggagga attggctgtg ggacacacag caatcctatt tcctgagcca gaacggcaca 1074541 gagatttcac gcaataacgt catgcggtcc gaatcaaagt ttcttgagta tgaaaacaat 1074601 gacaacacag atgttttgca agaatacttt gtgcccgtga aggagtatgg gtcctatatt 1074661 gatgacctga gacaaacgct gtcggacgaa gatctgaacc tgctgaacat tacgatccgc 1074721 tacgtgcaga aaaatgaaaa ggccgacctt tcctatgcga aggacgatat gttttcgctc 1074781 gtactattaa taaacgaggg cttttcaaaa gaagaccagg cagataccgc ccgaatcatc 1074841 aggcgcatga cagacgttgc catcaagcac ggcggcagct attatctgcc ttatatgacc 1074901 taccagacaa aagcgcaaat gagacaggca tatccgaaaa gtgaagcgtt ttttcagaaa 1074961 aaacgaacct atgacccgga tgagcgcttt atgaattact tttatcagag gtataaataa 1075021 tggggaaaaa caaattaaaa tggctgacat tatcacaaag cagcgtgttt ttcgcaagca 1075081 gcttaatctt tccgttttat attctgtttg tgaaaaatat cggctcaagc tacacacagt 1075141 tcggtttttc ctacggattg ttcgggttga gcggagcgct tatttacccg ctcctcggac 1075201 ggctgtctga aaggtttgac agccgttatt ttctgcttct gaactcgtgg gggatggctg 1075261 ttctgctttt atatgtcccg catatcggaa gcgtcgttca agtgtatatc gtccaagtgc 1075321 tgttagggct ctttggagcg atgcaaaagc atggagaaaa agtgctgatc gctaatttta 1075381 cagacagtgg agagcgtgga aagaagatcg ggaattacca tttttggaca gctgtctttt 1075441 cagcagcagc cattatgctc gggggctttc tcgctgactt tttcacagtg caaatgattt 1075501 tttatgcaag ctctattcta tattttttga gtggattgat gatgatgaaa acaggctgac 1075561 gcggtcagcc tgttttttta tgcggctgaa atgcggcacc gcatcaacgt ttttgtgctg 1075621 gagtcgtgct gatttttttt gagcggaatt cccattgaac agaaaattta taaatgaata 1075681 aaaatattaa atatacgatt gaattaattt ttattcatgt tataatgtta aataatttca 1075741 caaagaccaa gagggtgaac ttgttttgaa aataggaatt gtaggtgcta caggatatgg 1075801 aggcaccgaa cttgtcagga ttctttcgca tcatcctcat gcagaggaat gcatacttta 1075861 ttcatccagc ggagaaggga atgtctatag cgagggttat cctcatctta ccggcttagc 1075921 ggatcagcag ctgaagccga ttgatatgaa tacgatcaaa cacgaaatag atatcatgtt 1075981 tctcgctgcg ccgcccggag tatcaagtga attgactcca aagctggcag acgcgggaat 1076041 tacggttatt gatctgtcag gtgatctgag gataaaagaa ccggctgaat atgaaaaatg 1076101 gtataaacgg acagcggcac cgaaggcggt gattcaagag gcggtatacg gtctggcaga 1076161 actgaatcaa ctgcaaattc aacaggcgaa actcattgcc aatccaggct gttttccaac 1076221 agctgttttg cttggcctcg cgccattggc tcaaaagaaa ctgctcgatg aatctttcgt 1076281 tatcgttgac gcgaagaccg gtgtttccgg agcgggaaga aaagcatcca tgggaactca 1076341 tttttctgag ctgaacgaca attttaaaat ttataaagtc aatgaacatc agcacacgcc 1076401 ggaaattgag caggcgctga atgaatggca gccaggtctc gggcccatta cattttcggc 1076461 tcacttggtt ccgatgacaa ggggcatcat ggcgacgatg tataccagat taacctgtga 1076521 cctaaccgca gatgacctgc atgatttata ttcggaattt taccaagatt catattttgt 1076581 gagagtgagg ccaaaaggtc agtacccgca aacgaaagaa gtgtacggca gcaatttctg 1076641 tgatatcgcc gtgaccctcg atgagagaac gaacagagtc acgatcgtct cggtaatcga 1076701 taatttaatg aagggtgccg ccggtcaggc agtgcaaaac tttaatttga tgaatggctg 1076761 gaatgaagaa actggactca ccatcacgcc aatttatcca tagaacggga gagaatcgaa 1076821 ccatgattca gttaagtgaa gatcaaattg taaaagtaac aggtgatgta tcctcgccaa 1076881 aagggtttca ggcaaagggt gtgcattgcg gactgcgcta ctcgaaaaaa gacctcggcg 1076941 tcattatcag cgagacaccg gccgtgagtg cagcagttta tacccaaagc cactttcagg 1077001 ctgctccgat caaagtgaca caagacagct taaagcacgg accgacactg aaagccgtca 1077061 tcgtcaacag cgccattgcc aacgcctgca cgggagaaca gggcttaaag gacgcataca 1077121 caatgcggga gagctttgct tcacagcttg gcattgagcc ggagcttgtc gctgtttcat 1077181 caacgggtgt catcggcgag catttagaca tggaaaaaat ccacgcgggg atcgaactgc 1077241 tgaaagaaac acctgcggga tcaggcgatt ttgaggaagc gattttaaca actgatacgg 1077301 tgatcaagca gacgtgctat gaactggcaa tcggcggcaa aacagtcacg atcggcggag 1077361 cggccaaagg ctctgggatg atacacccga acatggccac gatgctggga tttgtgacaa 1077421 ctgacgcggc aatcgaagaa aaagcgctgc aaaaggcgct tcgggaaatc actgacgttt 1077481 catttaacca aatcacagtt gacggagaaa catccacgaa cgacatggta ttagttatgg 1077541 cgaatggctg cgccgaaaac gagtgcctga cagaagacca tccagactgg ccggtcttta 1077601 aaaaagcgct cttgctcact tgtgaggatc tagctaaaga gattgccaga gacggagaag 1077661 gcgcgacaaa actaattgaa gcccaagtac agggagcgaa aaacaatctt gatgcaaacg 1077721 tcattgccaa aaagattgtc ggctcaaatc ttgtaaaaac ggcagtatac ggaacagatg 1077781 ccaactgggg gcggatcatc ggagccatcg gacactccgc agcacaggtg acggcagaag 1077841 aagtagaggt ttatcttggc ggccaatgcc tgtttaagaa taacgaacct cagccattct 1077901 ctgaatctat cgccaaggaa taccttgaag gagatgaaat caccattgtc atcaagatgg 1077961 ctgaagggga cggaaacggg agagcgtggg gctgtgacct gacctatgac tatatcaaaa 1078021 ttaacgcgag ctatcgcacg taataaaggg gagcgaaatg aagaaaacaa tcgtttttaa 1078081 atgcggggga agcgtcatcc gtgagctgtc ggaggaattt tatcaaaatc tgaaagagct 1078141 gagggcgtca ggctggaagc tggcaatcgt acatggcggg ggaccggaaa tcacaaatat 1078201 gctgaaacgg ttaaatatca agacagagtt ttcgggcgga cagaggaaaa caacgaagcc 1078261 ggtgctggaa gtggcggaaa tggttttatc cggttctgtc aataaatttt tcgttgctga 1078321 gcttgccaaa cacggactgc gagccgcggg catttctggt aaggatggcg gtcttttgga 1078381 ggctgattat ctagatccgg aaacatacgg agaagtggga gaaatcaaaa aagtcgatgc 1078441 gtccatggtg aacgcgctga tggaaaatgg catcatcccc gttattgcgc cgctgtctat 1078501 gacaagcgac tgcaaaacgc tgaatgtaaa tgctgatctg gctgcttcag cagtcgccgg 1078561 agcgcttgaa gccgataagc tgatgttcgt cacggatgtc gatggaatca tgaaggaaaa 1078621 gcagcgtctg gacgtcctga cccctaagga gattcagatg ctgatcaagc aggaagtgat 1078681 cacaggaggg atgatcccga aggtcaattc agccttgtca gctttatcag atcaggtgtc 1078741 tgaagtcatg atcgtaaacg gtaaaggatc attcttcgca gaacaaacct ttcaagggac 1078801 aaaaattgtc aaagcaaagg aggctgtttc atgagcagct tgtttcaaac ctacggccgt 1078861 tgggatattg acatcaaaaa agcaaaggga acgtacgttg aggatcaaaa cggcaaaacg 1078921 taccttgatt tcattcaggg gattgcggta tcaaatctag gacactgcca tgaagcggtg 1078981 acagaggcag tcaaaaaaca gcttgacagc gtatggcacg tatccaacct gtttcaaaac 1079041 agtctccaag agcaagcggc gcagaagctg gcagcgcata gtgcgggaga tcttgtcttt 1079101 ttctgcaaca gcggcgcgga ggcgaatgaa ggtgcgataa agcttgccag aaaagcaact 1079161 ggaaaaacaa aaatcatcac ttttcttcag tcgttccatg gccgcacgta tgcagggatg 1079221 gctgcgaccg gacaggataa aatcaaaaca ggcttcggcc cgatgcttgg aggctttcac 1079281 tacctgccat acaatgatcc ttctgctttt aaagctcttg gggaggaagg cgatattgcc 1079341 gcggtgatgc ttgaaacagt gcagggagaa ggaggagtca atccggcgag tgctgaattt 1079401 ttatcagccg tacagtcgtt ttgcaaggaa aagcaagccc ttctcattat tgatgaaatc 1079461 cagaccggca tcggacggac gggaaaaggc ttcgcatatg agcacttcgg actctcaccg 1079521 gatatcatca cagtcgccaa aggattggga aacggctttc cggtcggcgc tgtcatcgga 1079581 aagaaacagc ttggagaagc gtttacccct ggttctcacg gaacgacttt cggaggaaac 1079641 atgctggcga tggctgctgt gaatgccaca ttgcaaattg tattccagcc tgactttttg 1079701 caagaggctg ctgacaaagg ggcgttttta aaagaacagc ttgaggcaga gctaaagagc 1079761 ccttttgtta aacaaatccg aggtaaagga ttaatgcttg gaattgagtg tgatggcccg 1079821 gttgctgaca ttattgctga attgcagaca ttaggcttgc ttgtattgcc ggccggcccg 1079881 aacgtgattc ggctgctgcc gccgctcacc gtgactaagg atgaaatagc agaagccgtc 1079941 agcaagctga aacaggcaat cgctcatcat tccgctgtaa accagtgatt ttttttcgat 1080001 ataaaggcat aaaaattcat ttttataatt aattattcat caagaggtgg gctgttagat 1080061 ggaaggttat ttagtgttag aagatgggac atcgttcagc ggcgagctgg acggtcatga 1080121 aaactgcacg ggagaagctg tttttttcac aggaatgaca ggctaccagg aagtgctgac 1080181 agatccatca tataagggac agattattgt atttacctac ccgctgattg gcaactacgg 1080241 cataaatgaa aaggattttg aaagcaagaa accgcaagta aaagccgcgg ttgtctatga 1080301 ggcgtgtgat cacttttctc attatgaagc ggtatacagc ctcaaggagt atctacagaa 1080361 atggaatatt ccgctgttaa cccatgttga tacgagggct gtcgtgaaga aaatccgggc 1080421 aaacgggacg atgggtgcga cagtcacagc ctctaaagaa ggagctgaga ttgcccttca 1080481 accagagaat gtggcagagc aggcttccgc ccaggaaatc agcacattcg gcgacgggaa 1080541 taaacatatc gctctcattg attttggcta taaaaagtca atcgcatcat cacttgtcaa 1080601 acgaggctgc aaggttaccg tggtgccata ccagcaaatg gaggccgtat acaacatcaa 1080661 acccgatggg ctatcgaacg gacctggaga tccgaaagcc attcagccat atttaggaaa 1080721 gatcaaaagc atcatcagcc gctttccgac tctaggcatt tgtctcggac atcagctgat 1080781 cgcgctcgcg tttggaggga atacttttaa gctgccattc gggcacaggg gagctaatca 1080841 tccggtcatc gaccgtaaga cgaaacgggt ctttatgaca agccaaaacc acagctatgt 1080901 ggttgatgaa cagtcgatta atgaagaaga gctcaccatc aggtttcatc atgtcaatga 1080961 tacgtcagtt gaagggcttg cccataaaaa actgcctgtc atgagtgttc aattccaccc 1081021 ggaagcccat cccggacctg cggaaagcga atggattttt gatgattatc taaagaatgt 1081081 gataccagca aggagagaaa tcgcgcatgc ctaaagacac cagtatttca agcatattag 1081141 taattggctc aggcccgatc atcatcgggc aggcggcaga atttgattat tcaggcactc 1081201 aagggtgcat cgcgctgaag gaggagggct accgggtaat tctcgtcaac agcaatccgg 1081261 cgacaattat gactgatgaa gccttcgctg atgaaattta ttttgagcct ctgacagcag 1081321 aaagcctgac agccatcatt aagaaagaac ggcctgatgg gcttcttgcc aatttaggcg 1081381 gtcagaccgc gttgaattta gcggtggagc ttgaagaaac gggtgtttta aaagagcacg 1081441 gcgtcaaact cctcggcaca tccgttgaaa cgatacaaaa aggagaggac cgggaaaaat 1081501 tccgttcgtt aatgaatgaa ttaaaacagc ctgtgccgga gagtgaaatt gttgataacg 1081561 aggccgatgc cctccatttt gcggaatcca tcggttttcc tgttattatc agaccagctt 1081621 acacattagg cggaaagggc ggaggaatcg cccctgataa agaagccttt acagctatga 1081681 ttaagcaggc gctattagca agcccgatca atcaatgcct tgtcgaaaaa agcattgccg 1081741 gctttaaaga aattgaatat gaagtcatgc gtgacagcaa taacacatgc attaccgtct 1081801 gcaatatgga aaatatcgat ccggtcggcg tgcatacagg tgactctatc gttgtggcgc 1081861 cgtcacaaac attgacagac gaagactatc aaatgctgcg gacagcaagt ctgacgatca 1081921 tctcagcact tgatgttgta ggcggctgca acattcaatt cgcgcttgat ccattcagca 1081981 agcaatatta cgtcattgaa gtgaatccgc gtgtaagccg gtcatcggct ctcgcatcta 1082041 aagcgaccgg ttatccgatt gcgaagatgg ccgcgaaact ggcagtcgga tacactcttg 1082101 acgagctgaa aaatccgctc acaggctcga cttacgcaag ctttgaaccg gcactggatt 1082161 atgtgatcgt caaatttccg cgctggccgt ttgataaatt caaaaacgca gaccgcaagc 1082221 ttggcacaaa aatgaaagcc accggtgaag tgatggcgat tgaacggaat ttagaagcgg 1082281 cgatacaaaa ggcagccgcg tcgcttgaat taaaaaatat cgggacacac cttccagagc 1082341 tcagcgggtt gtcaattgat acgctatggg atttggcaat cactccggat gaccgcagat 1082401 ttttcgttgt catggagctg ttgagccgca gcgtctcgat tgatgacatc catgaaaaaa 1082461 caaaaattga tccgtttttc cttcatacct ttgacaacat catcaaattg gaaaaccgcc 1082521 tgatggaagc agggagcgat ctctcttttg aattattgaa gaaagcaaag gaaaagggat 1082581 tctcagacgc aacgattgcc tcgctgatca gcaaaacaga agaagaggtg cgcgcgcttc 1082641 gcaaggagat gggcattacg ccttccttta aaatcgtaga tacatgcgcg gcagagtttg 1082701 atgcgaaaac aaactatttt tactccacat atttcggaga gaccgatgga gacatcagcc 1082761 gcaaagagaa aaaacgcgcg ctcattatcg gatcaggccc gattcggatc ggccaaggcg 1082821 ttgaatttga ttacagtgct gttcacggtg tgctgacact gcaagagctt gggttcgaaa 1082881 ccatcatgat taacaataac ccggaaactg tcagcaccga ttatgaaatt gcggaccgcc 1082941 tgtattttga accgatgaca acggagcata ttgtaaacgt ggcggagcag gaaaatattg 1083001 attttgcaat tgtgcaattt ggcggtcaaa ctgcaatcaa tgctgctgaa gcgctcgaaa 1083061 aagccggcat tactcttctt ggcacatcat ttcaaacgct cgacgtgtta gaggatcggg 1083121 atcaatttta tcagcttctt gacgagctgg gattgaagca cgcaaaagga gaaattgctt 1083181 atacaaaaga agaagccgct tcaaaagcga gtgagatcgg ctatccggtg ttaatccgcc 1083241 catcttacgt tatcggcgga atgggcatga tcattgttga ctcgcaagcc cagctttctc 1083301 agctgctgaa tgatgaggac agcatgccat acccgatttt aattgatcag tatgtgtctg 1083361 gaaaggaagt cgaaattgat ttgatttccg acggcgagga agtctttatc ccgacatata 1083421 ccgagcatat tgaacgggca ggtgtccatt caggggacag ttttgccatt cttcccggac 1083481 cgtccatcac gagcgggctg cagcagggca tgaaagatgc ggcacaaaaa attgcccgaa 1083541 aactttcatt taaaggcatc atgaacattc aatttgtgat cgacaatgga aacatactcg 1083601 ttcttgaagt gaatccgaga gcgagccgca cggttcctgt cgtcagcaaa gtaatgggcg 1083661 ttccgatgat tccgctcgcc acacgtctgc tggcgggagc gtccttaaaa gatctaaatc 1083721 cggcagttca aaatcatcat ggagttgccg tgaagttccc tgttttttct tctcatgcga 1083781 tccaggatgt ggatgtcaag cttggaccgg aaatgaaatc aacgggagaa ggcatgtgtg 1083841 tcgcatatga ttctaacagc gccttgaaaa aaatctatac aagagtctgg agtcaaaaag 1083901 gaagcattta tttgcaaaac gttccggaag atgtgaagga gttagcagaa aacgcaggtt 1083961 ttacaataca tgaaggaaca tttgcctcat ggatggaaca ggaaggaaac tcgctccaca 1084021 ttaatctgag cggttctgaa gaagcacgca aagaacgttt ggaagccatg acgcacggca 1084081 tccccgtctt tacagaagaa gaaactgtgc gggcgttttt acaaagcggt tcaggccatc 1084141 cgcagcctgt atctctcaaa gacctctata aaaaggaagt ggcatcatgc acacagtgac 1084201 gcaaaccagt ttatacggaa aagatttatt aacgttaaag gaccttagtg aagaagatat 1084261 aaacgccttg ctcgcagaag ccggtgagct gaaacaaaac aaaattcagc ctatattcca 1084321 tggcaaaacc ttggcgatga tttttgaaaa atcatcaacg cggacccgtg tttcatttga 1084381 agcgggcatg gcgcagctgg gcgggagcgc cctctttcta agccagaaag atctgcagct 1084441 ggggcgcggt gagactgtcg ctgatacggc aaaagtgctg tcaggctatg tggatgccat 1084501 catgatccgg acctttgaac atgaaaaggt ggaggaactt gccaaagaag ctgacattcc 1084561 ggtgatcaat ggacttaccg ataaatacca cccatgccag gcgctggcgg atctcttgac 1084621 gattaaggag ataaaaggga agcttaaagg cgtaaaagtc gcgtacatcg gtgacggaaa 1084681 taacgtggcg cactccttga tgatcggctg cgcgaaaatg ggctgtgata tctcgatcgc 1084741 ttcaccaaag ggatatgaag tgttagatga agcagctgaa gcggcaaaga catatgcact 1084801 tcaatccggc tcttctgtca cgctgacaga tgatccgatt gaagctgtaa aagacgcgga 1084861 cgtgatttat tctgatgtgt ttacaagcat ggggcaggaa gcggaagagc aagaacgtct 1084921 tgctgtcttt gcgccttatc aggtgaatgc ggcgctggtc agccatgcca agcctgacta 1084981 tacattttta cattgtctcc ctgcgcatcg cgaggaagaa gtgactgcgg agattattga 1085041 cgggccgaac tctgcagtgt tccagcaggc ggaaaaccgt cttcatgtgc aaaaagcact 1085101 gctgaaggcc attttatata aaggggaatc atcaaaaaac tgctgagcca aactcagcag 1085161 tttttttgat ggcaacatat tcacagccgc ttaggcgcat actacagcaa aaaggaaaag 1085221 gaggaaaaac agtgggacag cagcaccaat tccggcccgg acagaaagcg cctaataacg 1085281 gtgtctacgt agaaatcggc gagacaggga gcatggttaa aaaccctcaa aaggtccatc 1085341 tgtcagcagg ggaaatgttc cccgaaacat caaaccacaa ccggctgtgg acctacaaaa 1085401 gaaagccgtg accactaaaa aacccaaaac aataaatgtt ttgggttttt ggctttttaa 1085461 tgctggcttg catttttgtt cataggcatg atttctgcta aaaccatgat taagacatac 1085521 agtacaacag caatgacaga tgatgttttg aaattatacg taacgctgtt catgcttgca 1085581 accaagtagc atgccatatg tgataaaagg aacgtccaaa taaaggcaat aatatatcgc 1085641 acgtttccac ctcgtccttc tcattctatt ctaaaagtta tcataccata caaaaagcga 1085701 agggggaatc caattttagc agaaagtgag gtgacaaaag agtctgattc gtcacacttt 1085761 aatggtaaaa tataaaacgt caatcagtat aatagccaaa aatgtaaaag gctaggactt 1085821 taccttattc gtttcttttc tatttacata agatagcgtg agatgaagtg tgaaaggagg 1085881 cgggcaagcg atgggaataa cggaaagata ctttcaactg ggaacggagc ataatgtcat 1085941 tcatctgccc tatcgcccga acggcttcgg catctttatc ttgggggaca gaacccactt 1086001 tgtcggacat gattcaagct tttggcagca gcattatggc agaaatcagc ttctgagcat 1086061 gttgatgaat gaaggataca ctctttttaa cagcaatctg ttcggaaggc attggggggc 1086121 ggaaaaagca gtcacctatg ccaaacagct gatacattct gtgctgaagc aggaaatcct 1086181 caatccgaag attcatattt tagcagaagg catgggtgct ctcgtggccg atgaactgct 1086241 tcgtttttcc ccggatcata tccgctcagc cgcaatgttg aatccttgtc tcgatcttca 1086301 ggcacattat gaatcggaaa aagaaaataa atttttctat aagcaatttt tgaaagaagt 1086361 atcgaaaagc tacggaattt ctgaaaaaga agcggaagcg attcgttata aaacaattca 1086421 aagctacccg agcggcgtac cggttcatat atggcagcgt atgaccggag ctccatatcc 1086481 ctacagcgta catgcggaag ttttcaagga aaaacagcaa aagcaaggct caccggtcga 1086541 catgacattt catttatttg agcatccaag cagaatttat gcatcaattt gcaaattctt 1086601 tcatagtcat gaaaaagaat tatagagaat ataatgacaa cagccttctc ttttgcggag 1086661 gctgttttgt tttgggaaat gaaaaaccgg aagggcggca gatgcaatgg aatcaacgct 1086721 gattgtaggt gcggacgaat ttttcggcct ttcattatgt gagcgaatga tggatgaagg 1086781 catacatgtt gacgttgttc tggcggaaac agaagataaa atgagacaaa tgtacttaga 1086841 agaaagactc atgtggcttg ggagaaatga actctttcgc cagcttgaac acattggaga 1086901 ccaaaattat gatacaattt gtatccagtt cggaagtttt ttgcctttag accaatatga 1086961 ttctccttat attttagtat atgaagaaga ccgaaaagaa tgggataaac gtgaaaaaac 1087021 aggctcggaa aaaaccgtga tcctgccgaa aatgtacggg ccatggaaag aagaaacaga 1087081 ggaagacggc tattacacaa acgacgtggc tgacgagttg ctgagattcc tgttagaacc 1087141 aagccgtcat agcaaagatc agctttttga attgcaagtc acagagaaaa cctcaaaaga 1087201 agaagcaaaa acaaaaatta tcgagtggaa aagacaattt tcatcaattt tcgacaaata 1087261 ttaagaaaaa ccttccatgt ttcgagtttt ctagatacaa taaacgtata aaaataatac 1087321 atgttatagc ttgtcaaaag gagttgaaca tgacttgatc acaaggcttg tcatgatctt 1087381 ttctgtcctc cttttattga gtggatgtgg acaaactccg ttcaaaggaa aaattgagaa 1087441 ggtcggcatg ctctttcctg atacgattaa tgacctcgta tggggcacaa aagggtataa 1087501 aggattactg aatatacaat ccaaatacaa tgtggacgtc tattataaag aaggcgttaa 1087561 aacagaagaa gatatcataa atgcgattga ggattttcat aagaggggcg tcaatctgct 1087621 ctacggccat gggagtgaat atgctgaggt gtttaacttg gtcggcgaag attatccaga 1087681 tatggaattc gtcatttcca atgcgaaagc gaaagctgat aatgtaacaa gtgtccattt 1087741 tagcggggaa gcaatgggct tttttggagg aatgactgct gcccatatgt cgaaaacgaa 1087801 tcaggtcggt gtaattgctt cctttacgtg gcagcctgag gttgacggtt ttatcaaagg 1087861 ggccaagtat gaaaatccgg atatagaggt aaatacgaaa tatacggatc attgggatga 1087921 tgatacaaca gcagtaaagc tttatcagaa aatgaagaac gaaggcgcgg atgttgtgta 1087981 tcccgccgga gacgggtata atgttcctgt tattcagcaa atcaaaaaag acggtcttta 1088041 tgccataggc tacgtcacag atcaatcgga tctgggcgag aataccgtat taaccagcac 1088101 ggtgcaaaat gtggacaagg cctatgaaat cattgctgaa caatttaata aaggcaccct 1088161 tgagggcggc gatcattact acgacctgaa cacgggagtc gttgagatgg gaacattcag 1088221 cccgctcgtc gatcaagact ttcagcaaag aatcgccaag ctgatcaaaa catacaacaa 1088281 aacaggcgag ctgccaaaaa acgagtaatg gagtgacgtc acatgcagca cgaaaaatca 1088341 cttgaattct tgcaaattgc catgaaatat ctccctgaag cgaaagaaca gcttgagaaa 1088401 tcaggcattg agctctcaat ggaggccatc cagccgttta tgaatctatt tacaacggta 1088461 atggcggaag cttatgagct tggcaagtct gacgctaaat ctgaaacaga ataagaagaa 1088521 gccacttttt tgaaagtggc ttttcacatg attttctttt taatagcgga gagcatgggc 1088581 gcaagctcct ttaaagcggg cttgatttga tcaagagagt tcataattga accgatttgg 1088641 tccataatat gcatgtaatt aatcgtctct tcgtcgtttg tctgagaaac ctgagaaact 1088701 tcctcttgct gttcctcctc cttctcttct gttggttttg ctgcatcgcc gaacatcatt 1088761 cttgaaaaca catccaactg catacgcctc ctttccatat accatactct atgagtaaga 1088821 tgaactgata gtttagacga atatattgcc atgtgaaaaa aaataggata gaattagtac 1088881 ctgatactaa taattgatca caacctgatt gatcttctaa atttaagata taaaggagtc 1088941 ttccctaatg aaagctggaa tacttggtgt tggacgttac attcctgaga aggttttaac 1089001 aaatcatgat cttgaaaaaa tggttgaaac ttctgacgag tggattcgta caagaacagg 1089061 aatagaagaa agaagaatcg cagcagatga tgtgttttca tcacatatgg ctgttgcagc 1089121 agcgaaaaat gcgctggaac aagctgaagt ggctgctgag gatctggata tgatcttggt 1089181 tgcaactgtt acacctgatc agtcattccc tacggtctct tgtatgattc aagaacaact 1089241 cggcgcgaag aaagcgtgtg ctatggatat cagcgcggct tgtgcgggct tcatgtacgg 1089301 ggttgtaacc ggtaaacaat ttattgaatc cggaacctac aagcatgttc tagttgttgg 1089361 tgtagagaag ctctcaagca ttaccgactg ggaagaccgc aatacagccg ttctgtttgg 1089421 agacggagca ggcgctgcgg tagtcgggcc agtcagtgat gacagaggaa tcctttcatt 1089481 tgaactagga gccgacggca caggcggtca gcacttgtat ctgaatgaaa aacgacatac 1089541 aatcatgaat ggacgagaag ttttcaaatt tgcagtccgc caaatgggag aatcatgcgt 1089601 aaatgtcatt gaaaaagccg gactttcaaa agaggatgtc gactttttga ttccgcatca 1089661 ggcgaacatc cgtatcatgg aagctgctcg cgagcgttta gagcttcctg tcgaaaagat 1089721 gtctaaaact gttcataaat atggaaatac ttctgccgca tccattccga tctctcttgt 1089781 agaagaattg gaagccggta aaatcaaaga cggcgatgtg gtcgttatgg tagggttcgg 1089841 cggaggacta acatggggcg ccattgcaat ccgctggggc cgataaaaaa aggtgaggtg 1089901 cacacaagat gactaaaaaa agagtagttg ttacaggact tggagcatta tctccacttg 1089961 gcaacgacgt cgatacaagt tggaataacg caatcaacgg tgtgtccgga atcggtccga 1090021 tcactcgtgt tgacgctgaa gaatatccgg caaaagttgc cgctgaatta aaagatttta 1090081 atgttgaaga ttatatggat aaaaaagaag ccagaaaaat ggaccgcttt acacaatatg 1090141 cggttgtggc tgcgaaaatg gcggttgaag atgcagatct taacattacc gatgagatcg 1090201 cgccgagagt cggtgtttgg gtaggctccg gtatcggagg acttgaaaca ctagagtctc 1090261 aatttgaaat cttcttaaca aaaggcccaa gacgggtaag cccgtttttc gtgccaatga 1090321 tgattcctga catggcgaca ggccagattt ctattgcatt aggagcaaaa ggggtgaact 1090381 cttgtacggt tacagcatgt gctacaggaa cgaactccat cggtgacgcg tttaaggtta 1090441 ttcagcgcgg tgatgcagac gtgatggtca caggcggaac agaagcgccg ctgacaagaa 1090501 tgtcattcgc cggctttagt gccaacaaag cgctgtctac taatccagat ccgaaaacag 1090561 cgagccgccc gtttgataaa aaccgtgatg gctttgtcat gggggaaggt gcagggatta 1090621 tcgttcttga agaacttgag catgccctgg cccgcggcgc taaaatttac ggagaaattg 1090681 tcggctacgg ctcaaccgga gacgcttatc atatcacagc gccggcccaa gacggtgaag 1090741 gcggagcgag agcgatgcaa gaagccatta aagatgcagg cattgcacct gaagaaattg 1090801 attacatcaa tgctcacggg acaagcacgt attacaacga caaatacgaa acaatggcga 1090861 ttaagaccgt ttttggcgag catgcgcata aacttgcggt aagctctaca aaatcgatga 1090921 caggccacct cttaggagca gccggcggta ttgaagccat tttctctatc ctggccatta 1090981 aagaaggcgt gattccgccg acaatcaata ttcaaacacc tgacgaagaa tgtgatttgg 1091041 attatgtgcc tgatgaagcc cgcagacagg aacttaatta tgttctcagc aactcattag 1091101 gattcggcgg acacaacgca acattaatct ttaaaaaata tcaatcataa tcaagccaaa 1091161 ccggctgccc ttaaagggta gccggttttt tttgtgtgca taggattaaa agaggaggcg 1091221 atcacatgag tgtagaacaa acatatagct ggctcaggaa ggccggttca atagatgatt 1091281 tggcgcatta cattatcccg cttttttcag gtgcggagaa aaagaactgg aagggcattc 1091341 tggggcatct tcagcatcat gggatgttta aaaacataaa agagggtatt cagacggttt 1091401 ccaagctgaa ggaaaaaggt ttttacggac atatccaaaa ggaagaacag tacctcaaaa 1091461 acaaatggca aggtcctgat gtaccaattg ttacgctgcc ggttgatgaa cgaaacagga 1091521 gaatccgttt agaattcgga tcaaaatcag gactcgcctt tcaagacaaa atgttccttt 1091581 ttctttcgtc agatttagat tttgggtcgg tatctgccct tatgacgcat gagtatcatc 1091641 acgtttgccg gttaggtcat ctgacaaaag aggaaaagga tgtcacatta cttgatacaa 1091701 tcatcatgga agggctggcg gaatatgctg tttatgagag gttcggccga agtcaaacgg 1091761 ctgaatggac gacttggtat acaccggaac agcttcaggc tttatatgaa aaaaagattg 1091821 cgccccatcg ggatatcaaa cgggataatc gattatttcc ccagctgtta ttcggcaaag 1091881 gatatcagcc aaaaatgctt ggatacgcag ttggattcaa tattgtaaaa aaatatttaa 1091941 ccgccagcaa ggcaagcacc gcagacgggc tgtccattcc tgctgagacc tttttggatg 1092001 caatgcttta aaaggataaa ataatggaat ttcattaata atattacatt tatcctaaaa 1092061 aattcttgat tttgcaaaat gattgtaata atatacaact ataaaatttt tcgataattc 1092121 aatattattt attatttctg aataaaggga ttgctttctc ttgaaaacgt ttgacaacaa 1092181 gaggggggaa aggggagcta gcatgagcac acttttagaa gtgaataatt taaagactta 1092241 ttttttcagg aaaaaggagc cgatccctgc ggttgacgga gtcgattttc acatcagcaa 1092301 aggcgaaacc gtcgcgcttg taggtgaatc gggctccgga aaaagcatta cttctttatc 1092361 aattatgggc ctcgtccaaa gctcaggcgg aaaaatcatg gacggctcta ttaaactcga 1092421 agacaaagac ctcacctcat tcactgaaaa cgattattgc aaaatccgcg gtaacgaagt 1092481 atccatgatc tttcaggaac caatgacctc ccttaatccg gtgttaacaa tcggagaaca 1092541 aattaccgaa gtgctgattt accataaaaa catgaagaaa aaagaagccc gtcaacgagc 1092601 tgttgaactc ttgcagatgg tcggtttctc ccgggcggag caaattatga aggagtaccc 1092661 gcatcggctg tccggcggta tgagacagag ggtgatgatt gccatcgcac tgagctgtaa 1092721 tcctaaactg ctcattgctg atgaaccaac gacagcgctg gacgtgacaa tacaagccca 1092781 ggtgctggag ctcatgaaag atctctgtca gaagttcaat acatcgattc ttctcatcac 1092841 acacgactta ggtgtcgtgt ctgaagctgc cgatagagtg attgtcatgt actgcggaca 1092901 agtcgtagaa aacgccactg ttgatgactt atttttagaa ccgcttcatc cgtatacaga 1092961 aggcctgctt acgtcaattc ctgttataga tggagagatt gataaattaa atgcgattaa 1093021 aggcagtgtg cctacaccgg ataatctgcc gccggggtgc cgttttgccc caaggtgccc 1093081 gaaagctatg gataagtgct ggacaaatca gccttcgctt ttgacacaca aaagcggaag 1093141 aacggtgaga tgctttttat atgaggaaga gggtgccgaa caatcatgac agcagctaat 1093201 caagaaacaa tcttagagct tcgtgacgta aaaaaatact ttccgatccg gtcaggcctt 1093261 tttcaaagaa aagtcggtga tgtaaaagcg gtggatggtg tttcattttc gttaaaaaaa 1093321 ggagaaacac tcggaatcgt tggagagtcg ggctgcggaa aatcgactgc cggcagaacg 1093381 atgatcagac tgtacaaacc gacagagggc caaattcttt ttaaagggca ggatatttcc 1093441 aatctgtcag aggagaagct gcggaagagt gtccgcaaaa atattcaaat ggttttccaa 1093501 gatccatttg cttcgttaaa cccgagaaag accctgcgtt ccatcataaa ggagccgttt 1093561 aatacgcaca acatgtatac catgcgtgaa cgaaacgaaa aagttgaaga gctgcttgca 1093621 agagtagggc ttcacccgtc gtttgccggc cgttatcccc atgagttttc aggcggccag 1093681 cgtcagcgga tcggcattgc cagagcactc actttgaatc cagagctgat cattgcagat 1093741 gagccggttt ccgcacttga tgtatccatt caggcccaag tgattaactt gatggaggaa 1093801 ttacaggaag aatttaatct tacgtatcta tttatctctc atgatctgag tgtcgtccgc 1093861 catatcagcg acagagtcgg agtaatgtat cttggcaaaa tgatggaact gaccggcaag 1093921 catgagcttt atgacaaccc gcttcaccca tatacccaag cgcttttatc ctccgttccg 1093981 gttacaagaa aaagaggttc tgtcaaacgt gaacgcattg tcctgaaggg agaactgcct 1094041 agtccggcca acccgccaaa aggctgcgta ttccacacaa gatgtcctgt tgcaaaaccg 1094101 atatgcaagg aacaaatacc agaatttaaa gaagctgctc ccagccactt tgtggcttgt 1094161 cacctttata gctaatgttg cccgcacagc tttgagaggg ggtatgcaca ctacataaac 1094221 aacagcctag aagaacgaac atttcaagag ggggaatatc taatgaaaag acggaaaacc 1094281 gcactgatga tgctaagtgt attgatggtt ctggccatct ttttatcagc ctgctcggga 1094341 tcaaaatcaa gcaacagcag cgcgaaaaaa tcagcaggca aaccgcagca aggcggggat 1094401 ttggttgttg gttcaatcgg agaacccaca ctttttaact ctctgtattc taccgatgac 1094461 gcaagtacgg atattgaaaa tatgctgtac agctttttaa cgaaaacgga tgaaaaacta 1094521 aatgtgaaat tgtcactcgc tgaaagcatt aaagaattag acggcggcct tgcatatgat 1094581 gtgaaaatta aaaaaggcgt taagtttcat gacggaaaag aactgactgc agacgacgtc 1094641 gtatttacgt acagtgtccc tttaagcaaa gattacaagg gagaacgcgg ttcaacatat 1094701 gaaatgctga aatccgtaga aaaaaaggcg attacgaagt cttgtttaag ctgaaatata 1094761 aagacggtaa tttctacaac aatgcgttag acagcacagc tattctgccg aaacatattc 1094821 tcggtaatgt tccgattgct gatttagaag aaaatgagtt taacagaaag aaaccaatcg 1094881 gttcaggacc atttaagttt aaggaatgga agcagggcca atatattaag ctcgaagcga 1094941 atgatgatta ctttgaagga agaccgtatt tagatactgt gacgtataaa gtcattcctg 1095001 acgcaaatgc tgccgttgct cagctgcagg caggcgatat taatttcttt aatgtgcccg 1095061 ccactgacta caaaacggct gaaaaattca acaacctaaa aatcgttact gatttggcat 1095121 taagttatgt gtacatcggg tggaatgaaa aaaatgaatt attcaaggat aaaaaggttc 1095181 gtcaagcgct aacaaccgct cttgaccgcg agtcaatcgt cagccaagta ttagatggag 1095241 acggcgaggt agcttacatt ccggaaagcc ctttatcttg gaactatcct aaagatatag 1095301 atgttccgaa atttgagtac aacgagaaaa aagcgaaaca gatgcttgca gaagccggct 1095361 ggaaagatac gaacggtgac ggcattctgg ataaagacgg aaagaaattc tcgtttaccc 1095421 ttaaaacgaa ccaaggaaac aaagtccgtg aagacatcgc tgtcgtcgtt caggaacagc 1095481 tgaaaaaaat cggcattgaa gtgaaaaccc agatcgttga atggagcgct ctcgttgaac 1095541 aaatgaatcc tccgaattgg gattttgatg caatggtcat gggatggagt ttatccacat 1095601 tcccggatca atatgatatt ttccattcaa gccagattaa aaagggtttg aactacgttt 1095661 ggtataaaaa tgccgaagcg gataaactca tgaaagatgc aaaatcaatc agtgacagaa 1095721 agcagtattc aaaagaatat gagcaaatct atcaaaaaat tgcggaagat cagccgtata 1095781 cgttcttgta ttatcctaac aaccatatgg caatgccgga aaatcttgaa ggatacaaat 1095841 atcatccgaa acgtgatttg tataatattg aaaaatggtg gcttgcaaaa taaatttccc 1095901 ttaaagggga gggagagcgt tttctccctc ttctgttttt aataaggaaa gtaaaggggg 1095961 acaagtatat ggctgcatat attatcagaa gaaccttaat gtctatcccg attttattgg 1096021 gaattacgat tttatcattt gttatcatga aagccgcgcc cggagatccg atgacattaa 1096081 tgatggaccc gaaaatcagc caggctgaca gagagcagtt tattgaaaaa tacggtctga 1096141 atgatcctca gtacgttcaa tatttaaagt ggctaggcaa catggtgcag ggtgatttcg 1096201 gaacgtctat tgtcagaaaa ggaacgcctg tttcagaatt gattatggca agactaccca 1096261 atacgctcct gctgatgctg gtttcaacga ttttggctct tatgatttct attccgttcg 1096321 gtgtcctgtc ggcaaagcgg ccgtattcaa aaatcgacta tggcattaca tttacctcgt 1096381 ttataggcct ggctattcca aacttttggt ttggattaat tttgattatg gtgttatcgg 1096441 taaatctcgg ctggtttcca actgggggtg tcgagacact gaataccgaa ttcaatatat 1096501 ttgaccggat tcatcattta attctgcctg cattcgttct agctacagct gacatggccg 1096561 gactgacgag atacacgaga tccaatatgc ttgatgtatt aaatcaagat tatattcgca 1096621 cagcgagagc aaaaggattt aaagagaaca gagtgctatt taaacatgga ttgaggaatg 1096681 cattattacc cgtcattaca attttcggtt tgatgattcc ttcatttatc ggcggatctg 1096741 tcgttgtcga acaaattttc acttggccgg gattaggaaa gctgtttgtc gattcagcat 1096801 tccagcgcga ttatccggtt atcatggcaa tgactgtgat ctcggcggtt cttgtcgttg 1096861 tcggaaacct cattgcagac atcctttacg cgattgttga tccgcggatc gaatattaaa 1096921 aggagggaaa cagagatgtc agagctgcaa acaactccct cgccggagat caggctgaaa 1096981 gaaaatattt cgaaaaagcc agaaacaatg acaaagattt tctgggaaaa attctcgaaa 1097041 aacaaactgg ccattttagg tgccgttatt ctttttatca ttattatgtc tgctgttttc 1097101 gcccctttaa ttgcacctta tccccaagag cagcaaagcc tgcttgataa atataaggcg 1097161 ccgggccttg aacatctgat gggaacggat aaatttggac gtgatatttt cagccggatc 1097221 ctatatggag cgcgtgtctc tttattggtt ggatttgcgt ccgtagtcgg ttcgattttg 1097281 atcggaacgg ttttaggagc attagccgga tatttcagag gaatagtgga tgctgtcatt 1097341 atgcgtgtag ttgacattgt gttatccatt cctgatattt tcttgttgat cacgctggtc 1097401 accatcttca agccgggtgt ggacaaattg attttaattt tctgtctcac aggatggacc 1097461 acaacagcac gattagtaag gggagaattc ttgtcgctcc gttcaaggga atatgttctt 1097521 gctgctaaaa caattggaac aaaaacgcac aaaattattt tttctcatat cctgcccaat 1097581 gcgttagggc cgattatcgt gtcagctacg ctgaaagttg ggtctgttat tctagctgaa 1097641 tcggcgctaa gctacttggg ctttggaatc cagccgccaa tcgctagctg ggggaacatg 1097701 cttcaagacg cacagaattt cacagtaatg attcaagcat ggtggtaccc gttatttccc 1097761 gggctattta ttttaatgac cgttttatgc ttcaactttg tcggtgatgg cctgcgggat 1097821 gcgcttgacc cgaaaaatat taaataaaaa tgaatatcat atctgttata aaatatcacc 1097881 aaatcagaaa aaagcaggtc tcctttagtc agaaaatata caaagagatc tgctttttat 1097941 gattcttaca taaacccagt gattccagat ttcctcaatc tctttggaat aatttctcta 1098001 tcccttgcct atactgtgga caacagtttt tataaaagtg aggggttaga gatgttattt 1098061 cttcatgatg tgtgggtcaa ttggtttgaa ggggaagaaa atggctacaa tgtatgccac 1098121 tttcacgaat ggcgcaagga agatacggtt gagcttttgg atcaggtgcc gctgttaagg 1098181 gtgccgtcag tactgtttca ttacatagaa aacgatttgt cagagcttcc gaaaggtttg 1098241 cttgaagacg tacatcagaa atcgtacatt cgaaaaaatc atgagcggac aaagcttgag 1098301 tattgttttg tcgtaacaga cggaatcggc attttagctg ttgacacgat cggctacacg 1098361 atccctgtca gaaaaagccg tctaatccca agacaggagc agctcgttta tgaaatggta 1098421 aaagatgtag agcctgaaac atatgaattt gagccaaaga agctggaatc ctccaaggaa 1098481 tatcacatct tatcattagc accagaacat gtcagaggac tgacaagaaa agaacggcaa 1098541 attaagcagc tgatgtttat ggcgcttgac caattaaaag ggctgaaaaa ccgagcggaa 1098601 attggctact ggtacacaga gtggaatccg catatgtatg aacaaatcaa aaggatgagc 1098661 tttgaagaga tttgggacat gctgtataac gaaacaattg aaggctggtc ggacaaacac 1098721 ctagcttttt gcgaaaacct aataaaagga cagccttttt tcgaaaagct ttgggaaatg 1098781 gaaaacgaat caaaggtcaa ctgaaaaaaa ccgctctttg caaagagcgg ttttttgatt 1098841 agcgtctttt tcttccaaga cccatggcat tctccatttt tttcagcatt ttgtttgctg 1098901 tccgattcgc tcgttccgcg ccttcatcaa gaatccggtc taattcttca gattctatca 1098961 gctcgtaata gcggtcctgg atcggtttta atgcgttcac tacgacttct gccaaatcac 1099021 ctttaaactc gccgtagcct tttccttcgt actttgcttc aagctcttca attgtcgtat 1099081 tgccgaggat tgaataaatt gtaagaaggt tggaaacgcc cggtttgttt tccttatcaa 1099141 atttgacaat gccttcagaa tccgttactg cgcttttgat tttcttttca agctgcttcg 1099201 gctcatccag caatgtaata taagctttct gattcggatc agatttgctc attttcttca 1099261 gcggatcatt cagagacatg atacgtgcac cgacttttgg aattttcact tccggaatcg 1099321 taaagatgtc gttgtatttt ttgttgaagc gttctgcaag attccgcgtc agctcaaggt 1099381 gctgcttttg atcctcgccg acaggtacaa gatccgttcc gtacagcaga atatcagcgg 1099441 ccatcagcgg cggatatgtt aacaggccgg agacgacagc ttcattgcct ttggatttgt 1099501 ccttaaattg agtcatccgc tcaagctcgc cgatataggc gacacactgc atcatccatc 1099561 cggcctgcgc atgtgcgggg acctctgact gaataaacaa tgttgctttt tctggatcaa 1099621 gtccgacagc taagtaaagc gccgcgagat tgcggatatt ctttctaagc tcaagccggt 1099681 cttgaggaac agttatcgca tgctgatcga cgatgcaaaa atagctgtta taatcatgct 1099741 gcagttcgac aaactgcttc attgcaccga tatagttgcc gagcgtcact gagccgcttg 1099801 gctgaatgcc tgaaaaaatc gtttgtttca tgaaaacatc aacctcattt cttaaaacat 1099861 aataaaaaag gctcattctt cccctgtaaa aaagggacga atgaaccgtg gtaccaccct 1099921 gattattcca ttaaaatgga atcactctga cgtttgtaac ggagactgct ccggctgagc 1099981 ctactttttt ccagttcggt cagctgctcc aaagtccatt ccacattgcc cgttatctgc 1100041 tcccagcacc gcagactctc ttcaaacagg tgaaacgtgt actactcttt ttcatagcaa 1100101 gcttttcttt tgattgcttc attataaatc aattataacc aattgtcatc atgaaaaaac 1100161 attctttttt ccagtaaaat tgtaataata taaataacac gagtgctgta aaatccttaa 1100221 atgataactg ctatcagcgt aaaaacaggc agatattata tgtaaaaagc aatatgggca 1100281 gaaaacacat gaaaaagttt ttaatcaatt tatgctttaa atggtagaag gatattatgt 1100341 tcatggaaga aaaactaacg aagtttaaat attttaaatt gataaaataa tattgcaata 1100401 aattatttgt ttcattataa tgaacttgtt cactctattg ttacagcttt tttacaaaaa 1100461 taatcagaaa agacggaaca gaataaaagt tgtggaaact caggttcatt tgtctgatat 1100521 ttctgaggat ttagccgtaa ggagctgaaa attattatta gggggtttgc gaatatgaaa 1100581 aaacgttggt cgattgtcac gttgatgctc attttcactc tcgtgctgag cgcgtgcggc 1100641 tttggcggca gcggatcaaa cggtgaaggg aaaaaggaca gtaaaggaaa gacgacactt 1100701 aacattaata ttaaaactga gccgttctcc ttacatccgg gattggcaaa tgattcagta 1100761 tcaggcggtg ttatccgtca gacttttgaa ggattgacac gtatcaatgc agatggtgag 1100821 cctgaagaag gcatggcttc taaaattgaa acgagcaagg acggaaagac atatacattt 1100881 accattcgtg atggtgtgaa atggtctaat ggagaccctg taactgcaca agattttgaa 1100941 tatgcttgga aatgggcgct tgaccctaat aatgaatcac aatacgctta ccagctctac 1101001 tacataaaag gtgctgaagc ggcgaatacc ggaaaaggca gcctagacga tgtggcagta 1101061 aaagctgtga atgacaaaac gctgaaggtt gaattaaata acccgactcc atatttcact 1101121 gaattaactg cgttctatac gtatatgccg atcaataaga aaattgcaga gaaaaataaa 1101181 aagtggaata caaatgccgg agatgattat gtatcaaacg ggccgttcaa aatgacggca 1101241 tggaaacaca gcggctctat tactctcgaa aaaaatgacc agtattggga taaagacaaa 1101301 gtcaaactga agaaaatcga tatggttatg atcaacaata acaatacgga actaaaaaaa 1101361 ttccaagctg gcgaacttga ttgggccggt atgccgctcg gacagcttcc gacagaatcc 1101421 ctgccgaccc tgaaaaaaga cggttcttta catgttgagc cgattgcagg agtgtattgg 1101481 tacaaattca acactgaagc taagccatta gacaacgtca atatccgtaa agctttaaca 1101541 tattcgcttg accgtcagtc gattgttaaa aacgttacgc aaggagagca aatcccggca 1101601 atggctgcag tgccgcctac aatgaaggga tttgaggata acaaagaagg atacttcaaa 1101661 gacaatgatg tcaaaacagc aaaagaatac cttgaaaaag gcctaaaaga aatgggctta 1101721 agcaaggcat ctgatttgcc aaaaatcaaa ttgtcttaca acactgatga cgcacacgcg 1101781 aaaatcgctc aagcagtaca agaaatgtgg aagaaaaatt taggcgttga tgttgagctt 1101841 gataactcag agtggaatgt ctatattgat aagctccaca gccaagatta tcaaatcggc 1101901 cgtatgggct ggctcggcga cttcaatgat cctatcaact tccttgaatt gttccgcgac 1101961 aaaaacggag gaaataacga tacaggctgg gaaaatccag aattcaaaaa gcttctgaat 1102021 cagtcacaaa ctgaaacaga taaaacaaaa cgtgcagagc tgctgaaaaa agcagaaggt 1102081 attttcattg atgaaatgcc ggttgcccca atctatttct atactgatac ttgggtacag 1102141 gatgaaaacc taaaaggtgt tatcatgcca ggtactggtg aggtttattt cagaaacgca 1102201 tattttaaat aaggctacgt ctgaaaataa aagacctcaa ggtatatggg gagaaaagcc 1102261 ccatatacct ttcttactga tggagtataa aaatgtaaaa accatggagg tgttccccct 1102321 tgctaaaata tatcggaaga cgcttagtct atatgattat cacactattt gtgattgtaa 1102381 ctgtgacatt cttcttaatg caagcagcac cgggcgggcc attttcaggt gagaaaaagc 1102441 ttccgcctga aattgaagca aatttaaatg cgcattatgg cttggacaag ccgctgtttg 1102501 tacaatatgt cagttatttg aaatcagttg caatgtggga tttcggaccg tcatttaaat 1102561 ataaaggtca gagtgttaac gacctgatca gttcaggttt ccccgtttca tttactcttg 1102621 gagcagaagc tattctcctc gctttagcgt taggtgtatt gtttggggtc attgcagccc 1102681 tttaccataa taagtggcag gattataccg tcgcgatttt aacgatattt ggtatttcgg 1102741 ttccgagctt tatcatggcg gctgttctgc aatatgtgtt ctccatgaag cttgggctgt 1102801 ttccggtcgc ggggtgggat tcctgggcat acaccttttt gccttccatc gcacttgctt 1102861 ccatgccgat ggcgtttatt gccagacttt cccgttcaag catgatcgaa gtgttaaaca 1102921 gtgattatat ccgcacagcg aaagcgaaag ggctttcccg cccagcggtt acagtgcggc 1102981 acgccattcg aaacgcactt ttgccggttg ttacatatat gggcccgatg gccgcacagg 1103041 tcttaacggg gagcttcatt attgaaacca tttttgggat tccggggctt ggtgcacact 1103101 tcgtcaacag tattacaaac cgtgattata cggtcattat gggtgtaacg gtgttcttca 1103161 gtgtcatctt gctattgtgt gtattaatcg tagatgtgtt atacggcatt attgatccaa 1103221 gaatcaagct ttccaaagca aagaaaggag cctaggccat gcagaacatt ccaaaaaaca 1103281 tgtttgaacc agccgcagcg aatgccggcg atgcagaaaa aataagtaaa aagagccttt 1103341 ccctctggaa agatgcgatg cttcgcttcc gcagcaataa gcttgcaatg gtcgggctta 1103401 tcattatcgt acttattatc cttatggcaa tttttgcgcc gatgttctca aggtatgatt 1103461 attcaactac taatctctta aatgcggata agccgccttc aaaagatcac tggttcggaa 1103521 cagatgatct tggacgggac attttcgtcc gtacatgggt aggggcgcga atctcaatct 1103581 ttatcggtgt tgcagctgct gttctcgatt tgctgatcgg cgtcatttgg gggagcattt 1103641 caggcttccg cggaggaaga acagatgaaa tcatgatgcg tatcgctgat atcctttggg 1103701 cagttccttc attattaatg gttatcttac tgatggttgt tcttccgaaa ggtctattta 1103761 cgattattat tgccatgacg attacaggct ggattaatat ggccagaatc gtgcgcggac 1103821 aagtgctgca gctgaagaat caggagtatg tgcttgcttc acagacactg ggtgcaaaaa 1103881 catcccgtct tctatttaaa catatcgtgc caaacgcaat gggttctatt ttggtcacga 1103941 tgacactgac agttcctact gcgattttta cagaagcctt tttaagctat ttgggacttg 1104001 gtgttccggc tccgctggca agctggggaa cgatggcttc tgacggattg cctgcattga 1104061 cctattatcc gtggcgttta ttcttccctg ccggatttat ctgcattaca atgtttggtt 1104121 ttaacgttgt cggcgacgga ttaagagacg cattggatcc taagttacgt aaataaggga 1104181 gtgatacggg tgacacgcct attagaagta aaagatttag caatttcatt taaaacatat 1104241 ggcggagagg tccaggcgat ccgcggagtg aatttccatc tggataaagg ggagacgctg 1104301 gccattgttg gagaatcagg ttccggaaaa agtgtaacct ctcaagcgat tatgaagctg 1104361 attccaatgc ctccgggtta tttcaaacgc ggtgagatcc tgtttgaagg aaaggatctg 1104421 gtgccgctgt ccgaaaaaga aatgcaaaat gtccggggaa aagagatcgg catgatattc 1104481 caagatccga tgacctcttt aaatccaacg atgaaggtcg gtaaacaaat tacggaagtg 1104541 ctttttaaac acgaaaagat ctcgaaggaa gcggctaaaa aacgcgcggt tgaactgctg 1104601 gaattagtcg gtatcccaat gccggaaaag cgggtgaacc aatttccgca tgaattttca 1104661 ggcgggatga gacagagggt tgtcattgcc atggcgcttg cagcgaatcc gaaacttctg 1104721 atcgccgatg agccgacaac tgctcttgat gtaacgattc aagcgcaaat tttggaatta 1104781 atgaaggatt tgcaaaagaa aattgacacg tccatcatct ttatcacaca cgatcttggt 1104841 gttgtggcta acgttgctga ccgggtcgct gtcatgtacg cgggacagat tgtagaaact 1104901 ggtacggtag acgaaatctt ctacgacccg agacatccgt acacttgggg gcttcttgca 1104961 tccatgccga cactggaaag ttcaggagag gaagagctga ctgcaattcc gggcacgccg 1105021 cctgatttga caaacccgcc aaaaggagat gcttttgccc tgcggagctc ttacgcgatg 1105081 aaaatcgatt ttgaacagga gccgccaatg tttaaggtat ccgatactca ttatgtaaaa 1105141 tcgtggctgc ttcatcctga cgcgccaaag gtagagccgc ctgaagcggt aaaagcgaaa 1105201 atgcgtaaac tggcaaacac gtttgaaaaa cctgtcttag tgagagaagt tgaatgaatt 1105261 gactgaaaaa ctattagaaa tcaaacattt aaaacagcac tttgtcacgc cgaggggaac 1105321 ggttaaggct gtagatgatt tatcatttga tatctataaa ggtgaaacat tagggctggt 1105381 tggtgaatct ggctgcggta aatcgacaac aggccgaagc attatcaggc tgtacgaagc 1105441 aaccgatggt gaggtgctgt tcaacggcga aaatgtgcac gggagaaaat cgcggaaaaa 1105501 gctgctggaa ttcaaccgca aaatgcagat gattttccaa gacccctatg catccctgaa 1105561 tccgagaatg acagttgctg atattattgc tgaaggcctt gatattcata agctggcaaa 1105621 aacgaaaaaa gagcggatgc agcgagttca tgaactattg gaaacagtgg gattgaacaa 1105681 ggaacacgcg aaccgctatc ctcatgaatt ttccggcggc cagcgccaaa gaatcgggat 1105741 tgccagagcg cttgctgttg atccggaatt cattatcgcg gatgagccga tttccgcttt 1105801 ggatgtatcc attcaagcgc aggtcgtgaa tttaatgaaa gaactgcaaa aagaaaaagg 1105861 gctcacatac ctgtttattg cccacgattt atcgatggtc aaatacatca gtgaccgcat 1105921 tggcgtcatg tatttcggga aactggttga gcttgcgccg gcagatgagc tttatgaaaa 1105981 tccgcttcac ccatatacaa aatcattgct ttctgcgatt ccgcttcctg atccggacta 1106041 tgagagaaat cgcgttcgcc agaaatatga tccgtctgtc catcaattaa aggatgggga 1106101 aacgatggaa ttccgtgaag tcaaaccggg acattttgtg atgtgcacgg aagccgaatt 1106161 taaagctttt tcatgattca tcaatccttc aagagatttc tcttgaagga tttttttgcg 1106221 tcttcataga aagtgagaat gataacattt acaattagag gaaaaagcgg aggcgaaata 1106281 cgattcaatt tctgcataac aaaaatgttt ttgcgctatt gctgtctcaa tcttttcaat 1106341 ctttagcagg agtcctcgtc acaatcgttt taatggtccg gatctatcaa atgactgact 1106401 ccgttttttt ggcgggcctt attttatcgt tcatgtcgtt tgcgagtata gcagcaagct 1106461 tttgcgtctc tccggtgctt cgcattctcg gttttaaaaa ggtgcttgcg ggagcgaatc 1106521 tgctgagagc ggtctttatt atactgatgg catacagcgt cactcatcac ggacaggcat 1106581 tcttttggat tacgctgctg tttgtgtttt gtttttcctt cgcgggcgct ttttttcagc 1106641 cggcaagatt tgcgctgctg ccgattattg ttccaaagaa gcaatatgta aaagcgaatg 1106701 gtgtgatctc cctctcgaat caattgttct taacagcagg ctggggcctt ggaggccttc 1106761 tgacgtacgc cgtccctttt gaactcgttg tcggcgctgc catttgcctg tttgttctat 1106821 cgggagcttc catcagtgtg ctgcatgtaa atgaagaaga ggctgcagga actgctgaaa 1106881 cagcatctgt cagaagtata tggaaggatt taatgatcat ccctattgta agagacatta 1106941 ctgtaatgga catgttagaa gctttggcgg gttccgtatg gtcatctgct attctcctcg 1107001 catttactgc ggctgttttg catgaaacag aggtgtggtg ggggatgttt aacgcttcct 1107061 attttatagg cgcaattgtc ggcagtgtga ttgctattcg tttttcttct ttttttgagc 1107121 ggaatatggg ctatgccatt atgttcagct cgcttgtaat gtcggcgctg acccttttgt 1107181 tttcattttc tccagtccca tttttatgcg ctctggcttg tgctgcaatg gggccttttt 1107241 atcaggtgcg tgatatttgc caggaaacca tgctgcagga agttattccc gagcagaaac 1107301 gaatcggaat catggctgca aaaaatgcga ttttgactcc ttggtcaggc gtcacctact 1107361 ccattatggg gctagtggct gatgctgctg gtgcgaaaat agcttttatc gcggctgctg 1107421 cattatatat catgacattt ctgattgcac tggcgcagcc ccgtctggtt cattacaggc 1107481 gagaaaatcg agttcaatga gaaacacttc aaaatgaacg gagcagctgg ctccgttttg 1107541 ctgaaaaaaa aatgaaacca tggcggaagt tcgcacgtct ttatagatgt aaggctgttt 1107601 aaacaagaag aaatggggta tatctaaaag tatgaagaca acgaactcat aaggagcaaa 1107661 tcaatgaact ggtatgaaaa gcttagcgag tactttccaa ttgaagaaat gaaatcaaaa 1107721 gcgcatatgg aagctcttct gaaagagcga agcgatattt atcataaaga tgaaggcaaa 1107781 catcatattt taatgtttgc ggaattcgat tcttttatct tcgttgatta tctgtatgtg 1107841 tctaaggatg caagagggca ggggcttggc ggcaaattga tcgcgaagct gaaaaagaaa 1107901 aataagccca tattgctcga ggtggaacct gtggatgaag atgatactga tacagaaaaa 1107961 cgcctgaggt tttatcaaag agagcatttc aagcatgctc agtcaattgg gtaccggcgc 1108021 cggtcattgg ctacgaatga agtaaacaag atggagattc tgtactggtc accaaaaaca 1108081 gaatcagaag aagaaattct tgaagccatg aaacagacat atgaaaacat tcatacttat 1108141 aaagatgaga aatggtacgg agaatcgtac gaaaaaacgg atgaggtctt ggaaatcatc 1108201 gatgaagaaa aacaaaaaaa tattttcgat cagttaagct aattgagaat aagaacatat 1108261 catgaacatt aaaaatttgc tggattgaca catttttttc ttaggatact gttcacactt 1108321 acttttttat agtataatac ctgtaaagat tcctttttta gagtaatttc aatttaagaa 1108381 taaaatagat gttcatccta ctaattagag gagtgaagat gaatggttac actatacaca 1108441 tcaccaagct gtacttcatg cagaaaggcg agagcgtggc tcgaggagca cgagattcca 1108501 tttgtagaaa gaaacatttt ctctgaacct ttatcaattg atgaaataaa acaaattctt 1108561 cgaatgactg aggacggaac agatgaaatc atctcaaccc gttcaaaagt attccaaaaa 1108621 ctgaatgtga acgttgaatc tatgccgctg caagatttgt accgcttgat caacgagcat 1108681 ccaggtttgc ttcgccgtcc gatcatcatt gacgaaaaac gtttgcaggt cggatataac 1108741 gaagacgaaa tcagacgttt cctgccaaga aaagttcgct ctttccaatt aagagaagca 1108801 cagcgtttgg caaactaata gatcgtatca tcaaaagaag gctgagtcat cagccttctt 1108861 ttatttttca acctgctggt aataaatgct cgcaaggatg acaaacgcaa ccgtcaaaat 1108921 ggggaggagc gtttcgactg tgccgtgctg cgccataaaa agcgacagct ttttgtctct 1108981 gacaatcatt tctccgccag tataagcaag cagcccgctt cccgcgtaaa tcagaagcgg 1109041 tattttctct agtgcaatat ggatgagttt gctgccccaa ataataaccg gaaccgatac 1109101 acacaatcct ataacaacga gagaaaactc accgtgtgaa gctcccgcaa ctgcgatgac 1109161 gttgtccagc gacataaaga gatctgcaag cacaatcgtt cgtatcgctc tccacaggga 1109221 ggtgctgctt ttaatgtgtt tcgtgtcttt tttttcaatc agcagctgat atcctaaata 1109281 cagcaggaaa attccgccgg cgcactgcaa gaacggaatg ttcaaaagat atactgctgc 1109341 acttgttaat ccgattctca tggcaacggc aataaatgtt ccgagaataa tggcttgctg 1109401 tctttgcttg tccggcaaat gtctgctggc catggcaata acaaccgcgt tatctccgcc 1109461 gaggatcagg tcaatcccaa caatgacgag cagagaaatc agatagtcat gctccatgaa 1109521 gcggcacctc gctttcagtc cttcgcttgt actactacta tatgagacag gtcatatttt 1109581 atgatatcag ccgcctgatc tgccgttttt taggcaaagg tgcattttta tttcttttgt 1109641 gactgtttta tcataaaata gaaatacaaa ggaattcaca ctggccttgg ttaaggttaa 1109701 gatgtggacg gaatgggtaa agtgtagtaa agtacaatta atcgggagct tagatgtccc 1109761 ttcaacatct tatatagaag ggaaggttgg caaatggaaa ttgaaagaat taacgagcat 1109821 acagtaaaat tttatatgtc ttacggagat attgaagatc gcggttttga cagagaagaa 1109881 atttggtata accgtgagcg cagtgaagaa cttttctggg aagtcatgga tgaagttcat 1109941 gaagaagagg aattcgctgt ggaaggccca ctttggattc aagttcaggc actggacaaa 1110001 ggattagaaa tcatcgtcac aaaagcccag ctttccaaag acggacaaaa gctcgaactg 1110061 ccgattcctg aggataaaaa gcaagaacca gcatctgagg atcttgacgc cttgctggat 1110121 gatttccaga aagaagagca agccgtcaat caggaagaga aggagcaaaa gcttcaattt 1110181 gtcttgcgat ttggcgattt tgaggatgtt atttctctat ctaaattgaa cgttaacgga 1110241 agcaaaacga ctttatattc gtttgagaac cgatattatt tatatgtaga tttttgcaat 1110301 atgactgatg aagaggttga aaatcagcta agcatcctgc tggagtacgc aactgaatcc 1110361 tcaatcagca tacaccgtct tgaagagtac ggcaagctga ttatttcaga gcatgctcta 1110421 gaaacgataa aaaaacactt tgcatcatag caaaccgatt tccttccgga aatcggtttt 1110481 ttttatgcac gaaaatgcca ttttagagat gtgaaaaatc aaaaacatat agacaagcag 1110541 aaaatacagc gaacaggagt tgatcatctt ttccagaaag tatacttcat ctggaaagga 1110601 gagatgacaa ttgtttagtg ctgtgactga agacggccaa atgtttcacc ttctaggcgc 1110661 tcagcaaaac cagaaattaa agcggagacg gttcttctgt ccggtatgcg ggggagagct 1110721 agctgtgaag ctcggacttc aaaaagcgcc gcattttgcc cataaacaga acaagtcctg 1110781 cgccatagac atcgagccgg aaagcgccta ccacttagaa ggaaaaagac agctgtatgt 1110841 atggctgaaa acgcaacggg cttcaccaat attggagccg tatataagga caatcaacca 1110901 aagaccggac gtcatggcaa gaatcaagga gcatatgctt gctgttgaat atcaatgcgc 1110961 cactatcgct ccagatgtct ttcaaaagcg gacagagggc ttcaaacaag aaggaatcat 1111021 cccgcagtgg attatgggat acagccgctt aaaacggact gcttcgtcct tttatcagct 1111081 ttcaactttt cattggcagt ttatcaatgc aagtccatac agagaactga tatgttattg 1111141 tcctgaaagg cgttcttttc tccggctcag ccacatcatt ccattctaca caaaccattc 1111201 ttattcctca gtccaaacga tccctatcca tcgggcaggt gcaggcgatc tttttttcac 1111261 tgaaccgaaa ccctcaattc aatattcagg ctggacgaaa gcgattcacc gttttcgcca 1111321 taaaccccat cggtttaact caaaggaaac aaatcgcctt aggctgctgt tttatgagaa 1111381 acgacagacg cctttttctt ttctgccgac tgaagtgttt gttcctgtta gaaaaggggc 1111441 agtttttaag agtccggttt ttgtgtggca ggggtttctt tatttgttta tgacggatct 1111501 tggaggtaaa cgtgcgccaa ttcgtttttc agccgttttg cagcagtgca aactgcacat 1111561 tcataataag aacattgcac tcaggtccga atgcagcgaa gagtgtcttt cagaagcggt 1111621 taaacagtat attgattttt tgtgcaagaa gggattttta agggagactc agaaagaagt 1111681 atatgtgctg aatcagcctg caggaggcat acactccatg caggatctca tagaaagaga 1111741 ccgcagctgt tttatagaat gagtttgtct tatttggctc accctaagac aaaggtggtg 1111801 ggcaggctgt gaaaggcaca aaaggaaagg tttttcgtgt ttttactgct tttttggcat 1111861 tcgttctctt cattactgca tatgatttga caaaaggcag tgaaaaaccg gaagatattc 1111921 acaacacaag tttattgaga aacagctgtt ttttcaattg gcttgaatca aagaagacga 1111981 gggggatcac catggctgag gaaaaaaaag caaaccaact gcctgacaga agtgaggtaa 1112041 aggcagaaga cacatggaga cttgaggata tttttcctag tgatgaggcc tggaataaag 1112101 aatttcaagc tgtaaaagaa ttaattccga atttatctaa gtataaagga aagctggcag 1112161 attcagctga tcatttatac gaggctctta cgtatcaaga taaagtgatg gagcggctag 1112221 gtaggctgta cacatatgcg catatgcgct ctgaccagga tactgggaac tccttttacc 1112281 aggggctgaa tgacaaggcg ggaaacctgt atacacaggc cgcaagcgcg acagcttatt 1112341 tggttccgga gattttatcc atagaagaag acaaactgca gcagttcatt cttgaaaaag 1112401 aagaattgaa gctgtactct catgcgattg aggagattac aaaggaacgt ccgcatgtgc 1112461 tgagcgagaa ggaagaggcg ctgcttgctg aagcctccga ggtactgggg tcatcttcaa 1112521 atacattcag cgtgttaaat aacgcagata taacgtttcc atccattaaa gacgaagatg 1112581 ggaatgaaaa acagatcact cacggcaact ttattaattt cttggaaagt gaaaaccgtg 1112641 aagtccgcaa aaatgcgttt gacgcagtgt ataaaacgta cggacaatat aaaaacacaa 1112701 tggccacgac gctaagcggc actgtgaaaa aggacaactt ctacgcgaga gtgaaaaagt 1112761 acaagtccgc gcgtgaggct gcgctttcta acaacagtat tcctgaggaa gtatacgata 1112821 accttgttaa gacgattaat aagcatttgc cgctcctgca ccgctatatt gcgctaagaa 1112881 agaaagtgct tgagcttgat gaagtgcata tctatgacct gtatacaccg cttgtgaaag 1112941 atgctgggat gaaggtgaca tacgaggaag ccaaagatta catgctgaaa ggcctcgcac 1113001 ctttagggga agaatatgcc tctatcctaa aagaaggact ggaaaaccgc tgggtggacg 1113061 tttacgaaaa taaaggcaaa cgcaatgggg cttattcatc aggagcttac ggcacgaatc 1113121 cgtatatttt gatgaactgg cataataacg tcaataatct ctttacgctc gtgcacgagt 1113181 ttggacattc cgtacacagc tactatacga gaaagcacca gccttatcca tacggcaatt 1113241 acagcatctt tgtcgcggaa gttgcctcta cgacaaatga agcgctcctt ggcgaatatt 1113301 tgctgaacaa tttagaggat gaaaaacagc gcttatatat tctcaaccat atgcttgagg 1113361 gcttcagggg aacggtcttc agacaaacga tgttcgctga atttgaacat ctgattcata 1113421 caaaggcgca agaaggcgag ccgcttacac ctgagcttct gacaaatgtc tattacgacc 1113481 tgaataaaaa gtattttgga gacggcatgg tgattgataa ggaaatcggc cttgaatggt 1113541 cgcgtattcc gcacttctat tacaattact atgtgtatca gtatgcgaca ggttacagcg 1113601 ctgcccaagc attaagcagc cagattttga aggaaggaaa gccggcggtt gaccgttata 1113661 ttgacttcct gaaagcggga agctcacaat acccgattga tgtcctgaaa aaagcgggtg 1113721 ttgatatgac gtctccagag ccaatcgaag ccgcgtgcaa aatgtttgaa gaaaaacttg 1113781 atgaaatgga agagctgctg atgaaagtca agcagtctta aaaaagtaag cctgtgcgga 1113841 aatgacgcac aggctttttt aaaacccttt aaaggttttc cggtgattca agcggtagag 1113901 ggtaaacaaa atagacagaa acagcagagg agaggtaata taaagcggca gcatatgcat 1113961 catgcctaag atattcaagc agaaaaaaac agcaatgcac acaattgaga tcaaagtaga 1114021 catcatggcg gtcctcctcg tcctttttcc ttataaggat atgagtgaat gcacttcgtt 1114081 atgttttgtg acaaaaatat gaacattaag catagaggtt gtcaaaagtc gacatctttt 1114141 gttatcataa ggatgtgaaa ttgatcacaa acaaacatta cccctttgtt tgaccgtgaa 1114201 aaatttctcc catccccttt gttgtcgtta agacatatga aaccgcgctt atcccggcgc 1114261 ggtttcttta gtgctaaaaa tggaacgtac gtttggttat ggcataaaaa aacagcctca 1114321 agcatatgca cgcctgcggc tatttttcac atgattgata ttcatcagaa taagtgctga 1114381 gagacttcca aaacattccg tgtttggctt ccactttggc aaccttttta gcaaacgcca 1114441 gttttttcat ttctttttct acctcttcaa ggctcaggtc atatacaaga gcaatttcct 1114501 tcgaggcaac gaagcggaaa tattcaataa aacattctaa aggcggtgtt tccgacggct 1114561 tcggctcgtc gccaagcatc tcaaataaaa tttcttcata tacatcatat gagtagctgc 1114621 caggaacttt aagcccttca tcctcatgct gcgtattaaa aaacgtcagt gtcggattaa 1114681 cagaaacatc catctcggca gcaattttca tgtcacattg aagcgccttg accgcgcttt 1114741 gagaatgcag atcttttttg aattcttcaa gatcgagact tgtattttca gcaatctcca 1114801 aaagcacgtt ttcatccgta atatttttct ttgaaacaaa taggctctcc tgcatatttc 1114861 tgagaaattg catgccggct tttcgtcctt gcagttcggc tgctttaaaa gcgagagcag 1114921 ccatataagg cgatgaaagc ggctgatcct gttcgaacca gacattgccg tcacatgaca 1114981 tgccagagcg gctcgcgatc ttttcccatg cttctgcgag aagatgcttt tttcgctttt 1115041 tatttaaagc ggtaaggctt gcggaagcga taatgcgtaa ggtgaaaaaa cgtccgtatc 1115101 tgattttcag ctttttgatg acgggctcta aggaccagca ttcaggacat aaagggtcta 1115161 caaacatata aatttcaagc ggtttttttg gatgaccgtg gcaatgggcg aagtatagct 1115221 catgctgata gtttgtcaag atgatcgatc ctccgcttcc gtttgattca ccatatgcct 1115281 tgctgtcaac tccagccggc caaacaaaaa ctcacgaatt tcgccctcca gccctacatg 1115341 gtccattgcg tccttcatac agctgagcca cgcatcagct ctctcgtttg taattggaaa 1115401 gggaagatgc cttgctctga gcataggatg gccgtgttcc tcagtataaa gaggaggccc 1115461 gcctaaatac tgagttaaga attgcttctg tttcctggcg gtttctgtca aatcgcttgg 1115521 aaaaatcggc ttcagcaaag gatgagacgc gacacgctca taaaaagtat caacaagttg 1115581 cgatagaagt tcctctccaa tcgcttcata aggtgcgtta aacgattgtc ccatgttgac 1115641 tactccttta aatatggcta ataggaatca taaatcctat tgcaaaaagt aattttctgt 1115701 atttcattgt ttcatctaga tttattttag caacaaggca tcatttctac aaacaaactg 1115761 ccttttatgc gtttgatgac tcatttcggc tgacagccgg ggtttgtatt tcatatcata 1115821 tcacataaaa atcaggaatg cgtaagattt cacttcgcaa aaaaaccaga gggaaagagc 1115881 acctctggtt acgcgtaata aactgaagtt atttttttta catagttttg cgtttcttgg 1115941 aaaggaggaa tgcctccgta tcggtcaaca ttccccggtc cggcgttgta agccgctaat 1116001 gccatagaca cattgccgtc gtatttatcc agcatttgtt ttaaatattt cgttccgccc 1116061 tccacatttt gctgcggatc aagcggattg gaaacgccaa gtgagcttgc tgttgacggc 1116121 atcagctgca tgaggcccat cgcacctgct ccgctgaccg cttttgcatt aaagcctgat 1116181 tcctgtttga tgacggcgcg gatcagtttt tcatcaacgc catatttatc agcggctttt 1116241 ttaatcgcac tgtcaataga gaagtctccc gaacggatct gatttgcttc atgtttgttt 1116301 gaagctgaat ctgcaacagc tgtttcagtg ctttctgccg cttttgtgac tgaacctgaa 1116361 ttgctgctcg tatatgagtt aagcccatac gctgaaagca gtgacggcgc tgttgtattc 1116421 gcgctgttca gcatgctgag cgggcttggc gatgaagaag gtgctgattg ctgagatgtc 1116481 agaccgtttg tatattggct gagcaaagaa ctgaaacttg aaagcgggct ttccgtattc 1116541 tgagtgtccg agctgctgcg tgcattagat atggactgta atgcctgaag ctgaagtaat 1116601 gctgcccaat tcgttacatt cacgatgtca ttccacctta tatagacttt cgtttttctt 1116661 cataaaaacg cagaatttta tttttggttt cgcgctgagg aatgctgaat tgctgaagca 1116721 gcttttcgaa ggcttgtctg ccctcatgcc aatccgccgc ctcaaattca atttcatagt 1116781 cctctttatt taaatatcgg ctgtggtcta aaactattaa gcctttttct gtttcttttt 1116841 ccgcacggtt tgttgctaaa gatccaaagt attgtatggc atccgtatcg atctgaagct 1116901 tgtgcagctg gtccttcaca gggccctcgg gaactgaaaa tccagcgaga tctgatacct 1116961 ctgaaagctg ctggtgcgtt tccagaagcc ccacatcagc cggctccttt aatgtaagga 1117021 catactttcc gttttttctg cggatacgaa gcgcagcatg tttttgtttc agcgcgaagc 1117081 tgtctgtatc aaaataatga ttcttttgat ctgtaaaatc tttttctgtc agctggagtg 1117141 ccgatgctat gtttttgaat tcttgtttgg tcagcatgtt tttaaattcg atttcaatct 1117201 cttggctcat gatgctcttc ctttccgccc tgtaaatctt atttttacta ttatctcttt 1117261 agatgttagg tttatcaata tcgagctcga tatgataaaa tgaatctgta ctttgtttaa 1117321 aaaaggagag cattatgcaa aacagaatcg aaattttgaa tgcaacatta tcggatgatc 1117381 agcttcgcct tgcctgtcag acagaaggaa acgaagcgga acgcaagccg tcaggtcaaa 1117441 tgcttgttga ttctgaccac tttgcttttg tatacatact tgaattagct gattcttttg 1117501 aatatgtcat tataaaggaa catgtatggc cggaactgaa gcaggcccat gcacaaaaaa 1117561 taccggttgt tttagaggca ggagaccaaa caattgaact ggcaggcctg catgaggagc 1117621 tggaatatct tttagaaaat ataaaagata atgcaaacta tggagaagaa atggaagaaa 1117681 aagtgaaacg cgtgttttta tagaaactgg ttcggaattg ggggatgtat gatggatgac 1117741 aaacaatggg agcgtttttt agtgccgtac cgccaggctg tcgaagagtt gaaagtgaag 1117801 ctcaagggga tccgcacact atatgaatac gaggacgacc attcaccgat cgaatttgtg 1117861 accggacgcg tcaagcctgt ggcgagcata cttgaaaaag cgagacggaa aagcataccg 1117921 ctgcatgaaa ttgaaaccat gcaggacatt gctggcctta gaatcatgtg ccaatttgtc 1117981 gatgacatcc aaatcgtaaa agagatgctt tttgccagaa aagatttcac cgttgtggat 1118041 cagagggatt atattgcgga acataaagag agcggatacc gatcatacca tcttgttgtg 1118101 ctgtaccctt tgcagacggt atccggagaa aagcatgttc tcgtagaaat acagatccgt 1118161 acactggcga tgaatttttg ggcgaccatt gaacattcat tgaattataa atacagcgga 1118221 aacattcctg aaaaagtaaa actaaggctt cagcgcgctt ctgaagcggc ttcccggctt 1118281 gatgaagaga tgtcggagat caggggtgaa gtacaggaag ctcaagctgc cttttcaaga 1118341 aagaaaaaag gaagcgagca acaataggta aaggggaaga agagcatgaa atttgccgta 1118401 tcatcaaaag gagatcaagt ttctgatacg ctgaaaagca aaatacaggc gtatttattg 1118461 gattttgata tggaactgga tgaaaatgaa ccggaaatcg ttatttcagt cggaggcgac 1118521 ggaacgcttt tgtatgcttt tcacagatac agcgaccgtt tggacaaaac agcatttgtc 1118581 ggcgttcaca caggtcatct gggtttttat gccgactggg ttcctcatga aattgaaaaa 1118641 cttgttcttg ccatcgcgaa aacgccgtat catacagtcg aatatccgct tctcgaagtc 1118701 attgtgacct atcacgaaaa cgagcgggaa gaaagatact tagctttgaa tgaatgtacg 1118761 attaaaagca tcgaaggaag ccttgttgct gatgtggaaa tcaaagggca gctctttgaa 1118821 accttccggg gcgacggcct ctgcctgtca actccatcag gcagcacagc ctacaataag 1118881 gcgctgggcg gagcgattat ccatccgtct atcagggcga tccagcttgc ggaaatggct 1118941 tcaattaata accgcgtgtt ccgtacggtc gggtcacctc tgcttctccc atcccatcat 1119001 gattgcatga ttaagccgag aaacgaagtt gactttcaag tgacgattga ccatttaacc 1119061 cttctccata aggatgtaaa gtcgatccgc tgccaagttg catccgaaaa agtgcggttt 1119121 gcgagattcc gtccgtttcc attttggaaa agagtccagg attcgtttat tggaaaaggt 1119181 gaatagaaag aggacatatc gtggagcatt tttttatcag aaagaacatt acttccgctg 1119241 aggacgggat gactgtaaaa gaatatgccg gtgaactggg aatttcgaaa cgtctgctga 1119301 ccgatattaa gtttggcggg ggagacctgc agattaacgg tgagcatgtg acggtcaaat 1119361 acgttttgaa agagggagat cttcttatcg tgaagtttcc tgaggagcag gtgagcgaga 1119421 cgctgttggc agagcctgtt ccgctcgata tcctttatga ggatgaacat gtgcttgtga 1119481 taaacaagca gccgtatgtg tcatcaatcc cttcgagaga gcacccctcc ggcagcattg 1119541 ccaatggaat tattgatcat tatcaaacaa ccggagtgag ggcgacagtt catcttgtca 1119601 cccggttaga ccgggataca tcaggtatca tgcttgttgc caagcatcga tttgcccact 1119661 ccattttatc gtctgcgcaa aaaaacggcc ttgtgaaacg ccggtatgcg gcagtggttc 1119721 acgggcggat ggcacagatg gagggaacag tcgatgctcc gattggcaga catcctgaca 1119781 gtattattga acggacggta acgccagacg gccagaaggc tgttactcat ttttacgtca 1119841 catgtgcaaa tgatgacatg acctcggtgg cattgcagct tgagactgga cgaacccatc 1119901 aaattcgtgt tcatatgagc tatctcgggc acccgttgtg cggcgataca ctgtacggcg 1119961 gaacgagaca ggaaattggc cggcaggctc tgcacagcga gcatctttcg tttatccatc 1120021 cgctgacaca ggagaacatg aggtttcatg ctccactgcc tcaggacatg agcaaactga 1120081 taaaaggaga gaatcattga ttctctcctt ttttatatgg ggcgaaatct tgattcgtcg 1120141 taaggcaggg agcttggaac agagacggtt tctatttctg gaaagcgaaa gcctgtcagt 1120201 tgatttccga acacgcagcc tgtatcaatg ttgatggtgc gattgacctt ccgaggctct 1120261 ttcacaggtg tatgaccgta taccacccaa gcctttccgt tataggctgc cgcccaatca 1120321 cgcctgatgg gtctgccgtc cggatatgtt tcacccgtca cgtcaccgta aagcacaaag 1120381 tccttcactc tgcgggtata tttgccgata tcgtcagctc ttatgccagc atgggcgaca 1120441 actaattctc cattatgtaa gatgtcgtaa agcggcgctg tttcgtacag cttcataaac 1120501 tgttcgctga ctgatttttt ctcatctttg gaaagttcct caagctctgc cgctgttgtt 1120561 tcgagaccat gcatcacttt taccggattt ccttttaagt aacgatataa tttattgcaa 1120621 tggtttcccg ggacataacg cacagcgcct ttttcgtaag cgccggctac aaatcggatg 1120681 acctctatcg atttgggccc tctgtcagtt aaatctccgg caaaaacaag caccctgcct 1120741 tcttcatgga caggtactcc atttttgatt gtatagccaa gcttttggat taatgcagtc 1120801 atttcgtcat agcagccatg aatatcgctg atgatatcgt aagccatgcg gtctcctcct 1120861 taccgattgt tttatttatt atgaagcaaa gtgttgtgag tcatcacaag cttttatgtg 1120921 caaattatag aagaagaatc attttctaaa caggattaag accttatcac tttatttttc 1120981 atcatcaccc ttgttaaaat cgcgttatgt tttttaaaaa tgaggttttg ttctctgagt 1121041 gagaactagc ataaccctga cttaaaaagg aggttctgat tatggcgcat acatctgtcg 1121101 catctttagt tgttgtactt atcgttgcat ttttgacacc catccttttg catcggttta 1121161 aactcagcat cccggttgtt gttgctgaaa tcattatggg gctgataatt gggaaaagcg 1121221 gccttaattt agttgtggag ggtgacacct ggctccagac actctctatg ctcggattta 1121281 tctttttaat gtttttaagc gggcttgaaa ttgatttttc gtcgtttgag aaaggaaaga 1121341 aaaagcagtt cctgccgaat ggcaaggaag cgccgaatac gtttgctgcg gcatctgtta 1121401 ttttcgtcgg tatttttatt ttatcattgc tcttgtccta tgggttcgtc ttggccggat 1121461 ttatccaaaa tgcatttttg atgaccctga ttatttcaac gatttcatta ggcgttgtcg 1121521 ttccaacatt aaaagaagaa cggatcatga attcgaatat cgggcagatt attttgcttg 1121581 ttgctgttat tgctgatttg gccacgatga ttcttcttgc tgttttttct tctttatacg 1121641 gagaggacag cggaaacatg tggctcctga tgattctgtt tgcggccgga gtggtgcttt 1121701 actttttcgg ccgggtcttc aaacatcgct cttttgttca atccatgtca aaagggacga 1121761 tccagatcgg gacgcgtgcc atttttacgt taatcattgt actcgttgcc ctgtctgaat 1121821 cacttggggc ggaaaatatt ctcggcgctt tcttagcggg ggttcttgtt tccctgcttt 1121881 cgccaaacaa agaacttgtt cagcagctgg actcattcgg ttatgggttc ttaataccga 1121941 ttttcttcgt gatggtcggt gtgaagcttg atatttggac tcttttccag gataaaacaa 1122001 ttttaatcat gattccgctc ctgctgcttg cgctgttagt cagcaaaatc attcctgtca 1122061 tgtacttaaa gaagtggtat gataaccgaa ccattttcgc gtctggtttc ctgctgacat 1122121 caacgctttc gctcgtgatt gctgctgcaa caatcggcca gcagcttcac gtgatcagta 1122181 caaatatgtc aggagcgcta attttagtag ccgtcattgc aagtattttt acgccgatct 1122241 gttttaaaaa attatacaaa cgggaagagc agccggagga gaaaaagacg attacgttca 1122301 ttggcgccaa tcaaatgact ttgcctgtca cactcgaatt gccagaggaa gagtatgacg 1122361 tgcgtgttgt acacgtctac caagagaatg cggaggaaaa gctgtcagaa tcagtgtttg 1122421 ctgttgaaac aatttctgac tatgaacacg agacgcttga atcactcggc atttttgaaa 1122481 cggatatcct cgttgtggcg acaggaaatg aagatatgaa tgcagacatt gcattacttg 1122541 caaaagataa aggcacagaa agagtcattg caagcgtagg atcaccggag catgaagcag 1122601 ctctgaagga gcagggaatc agcatctttt ctattctgct gtcgacaaaa acgctgcttc 1122661 gcgcactgat tgaagcgcct ggcgtcatga agctgctcac gaaccaagag tcttcgctgt 1122721 atcaaattaa tatggagaac agtaaatatg atggtgtcat tttacgggaa ttccctttaa 1122781 caggtgacgt catctttgtc aggatcttca gaggtgtgga cagcatcgtt cctcatgggg 1122841 atacgaggct gaaacttgga gaccgtttaa ttgtcaccgg atctcggggg tacgtaacgg 1122901 atcttaagaa aacattggaa ggataaatct tgaccaaata aggattcgtg ttaatataga 1122961 ggtgcagaac aattcaatat gtattcgttt aaccactagg ggtgtccttc ataagggctg 1123021 agataaaagt gtgactttta gaccctcata acttgaacag gttcagacct gcgtagggaa 1123081 gtggagcggt atttgtgtta ttttactatg ccaattccaa accacttttc cttgcgggaa 1123141 agtggttttt ttattttcag agggggaatg atttgtgaag ttttcagaag aatgccgcag 1123201 tgcagccgca gaatggtggg aggggagctt tgtccatccg ttcgttcaag gaatcggtga 1123261 cggaacgctt ccgattgacc gttttaaata ctacgtactt caggattcct attatttaac 1123321 gcattttgca aaggtgcagt catttggtgc cgcttatgcg aaggatcttt atacaacggg 1123381 gcggatggca agccatgccc aaggtacata tgaggcggaa atggcgcttc atcgcgagtt 1123441 tgccgagctg ttggaaatca gcgaggaaga gcgtaaggcg tttaagccgt ctcctacggc 1123501 gtactcttat acatcccata tgtaccgttc ggttttgagc gggaatttcg cagaaatctt 1123561 agcggccctg ctgccatgct attggctcta ttacgaggtt ggtgagaaat tgctgcattg 1123621 tgatccgggg catccaattt atcagaagtg gattggcaca tatggcggtg attggtttag 1123681 acaacaggtc gaggagcaaa tcaaccgctt tgatgagctg gcggaaaaca gcacggagga 1123741 agtgcgtgcc aagatgaaag agaattttgt catctccagc tactatgaat atcaattttg 1123801 gggaatggcc tatcgaaaag aaggctggtc tgacagcgcc ataaaagagg tggaggaatg 1123861 tggagcttca cgccataacg gatgacagca agccggtaga agagctagcg agaatcatca 1123921 ttacgattca gaatgaagtt gattttattc acattcggga acgctcaaaa tcggcggcgg 1123981 atattttgaa actgctcgat cttatttttg aaggcggtat agataaacga aaattggtga 1124041 tgaacgggcg cgtggatatt gcacttttct ctactattca ccgcgtgcag ctgccaagcg 1124101 gcagcttttc accgaagcag atcagagcca gatttccaca ccttcatatc gggaggtcgg 1124161 tgcattcact ggaggaagcg gttcaagcag aaaaggaaga cgcggactac gtgctgttcg 1124221 gccatgtgtt tgaaacggat tgcaaaaagg gtcttgaagg cagaggagta tctttgctgt 1124281 cagatatcaa acagcggatt tccatcccgg ttatagccat cggggggatg acgccggaca 1124341 ggttaagaga cgtaaaacaa gcaggggcag acggcattgc tgttatgtca ggaattttct 1124401 cttccgctga acctttggaa gcagccagac gatattcccg caagctaaag gagatgcgct 1124461 atgaaaaggc attatgaagc agtggtgatt ggaggcggaa ttatcggttc cgcaattgct 1124521 tattatttgg caaaggaaaa caaaaacacc gcattgtttg aaagcggaac aatgggcggc 1124581 agaacgacaa gtgccgctgc cggaatgctg ggcgcccatg ccgaatgcga ggaacgtgac 1124641 gcgttttttg atttcgctat gcacagtcag cgtctgtaca aaggtcttgg agaagagctt 1124701 tatgcattat ccggtgtgga tatcaggcag cataacggcg gtatgtttaa gcttgcattt 1124761 tctgaagaag atgtgctgca gctgagacag atggacgatt tggactctgt cagctggtat 1124821 tcaaaagaag aggtgttaga aaaagagccg tatgcgtctg gtgacatctt tggtgcatct 1124881 tttattcagg atgatgtgca tgtggagcct tattttgttt gcaaggcata tgtgaaagca 1124941 gcaaaaatgc ttggggcgga gatttttgag catacgcccg tcctgcatgt cgaacgtgac 1125001 ggtgaagccc tgttcatcaa gacccctagc ggagacgtat gggctaatca tgttgtcgtt 1125061 gccagcgggg tgtggagcgg aatgtttttt aaacagcttg gactgaacaa tgcttttctc 1125121 cctgtaaaag gggagtgcct gtccgtttgg aatgatgata tcccgctgac aaaaacgctt 1125181 taccatgatc actgctatat cgtaccgaga aaaagcggaa gactggttgt cggcgcgaca 1125241 atgaagccgg gggactggag tgaaacaccg gatcttggcg gattggaatc tgttatgaaa 1125301 aaagcaaaaa cgatgctgcc ggctatacag aatatgaagg tggatcgttt ttgggcggga 1125361 ctccgtccgg gaacaaagga tggaaaaccg tacatcggca gacatcctga ggacagccgt 1125421 attttatttg cggctggcca tttcagaaac gggatcctgc ttgctcccgc aacgggcgct 1125481 ttgatcagtg atctcatcat gaataaagag gtcaaccaag actggctgca cgcattccga 1125541 attgatcgca aggaggcggt tcagatatga tgctacagct gaacggtaaa gacgtgaagt 1125601 ggaaaaaaga cacaggtaca attcaagacc tgctggcgtc gtatcagctt gaaaataaaa 1125661 tcgttatcgt ggaaagaaat aaagaaataa tcgggaaaga acgctatcac gaggttgagc 1125721 tttgtgatcg tgatgtcatt gaaattgtcc attttgtagg aggcggatga gcatgttaac 1125781 aattggcgga aaatcatttc aatcaagatt gctgctgggc acggggaaat acccatcgtt 1125841 tgacattcaa aaggaagcag tagctgtttc tgagtctgat attttaacat ttgctgtaag 1125901 gagaatgaac atttttgaag catctcagcc gaattttctg gaacagcttg atttatccaa 1125961 atatacgctt ttgccgaata cagcgggcgc cagtactgct gaagaagcgg ttcggattgc 1126021 aaggctggcg aaagcttcag gcctttgtga catgattaaa gttgaagtca tcggatgcag 1126081 ccgttccttg ctgcctgacc ctgttgagac attaaaagcg tctgaacagc ttcttgaaga 1126141 aggctttatt gtgctcccgt acacgtcgga tgacgttgtg ctggcgagaa agctggaaga 1126201 gctcggcgtt catgccatca tgccgggtgc atctccgatt ggatcaggac aaggaatctt 1126261 aaatcctttg aatctgtcgt ttattattga acaggcgaaa gtaccggtca tcgtggatgc 1126321 gggaatcggc tcgcctaaag atgcggcata cgcaatggag cttggagcgg atggcgtact 1126381 gctcaatacg gctgtatctg gcgctgacga tcccgtgaaa atggctcgtg ccatgaagct 1126441 cgcagtggaa gcagggcgcc tttcttatga ggcgggccga atcccgctta agcaatacgg 1126501 aacggcaagc agtccgggag aaggtcttcc tgtatgacag gcaggtattc aaggcaggag 1126561 ctgtttgctc cgatcggccc atccggccag aaaaaattga aagaagcgcg cgccgtgatt 1126621 atcggcgccg gcgcgctcgg aacagccagt gcagaaatgc tggtgagagc gggagtcggc 1126681 tctgtgaaaa ttgccgacag agattatgtt gaatggagca acctccagcg ccagcagctt 1126741 tatacagaag atgatgtcaa aaaagaaatg ccgaaagcag ccgctgcgga gcgccgtctc 1126801 cgttcgatta acagcgatgt tgatgtgacc ggccttgtca tggatgtgac agcagaaaat 1126861 atcttcgagc tgattaggga tgcatcgatt attgtggatg cggctgataa ttttgaaacc 1126921 cgcctgatcg taaatgatgc tgcggtaaag gaagggattc cttttcttta cggtgcctgt 1126981 gtagggagct acggtcttac ctttaccgtg gtgccgggtt ctactccttg cctgcattgc 1127041 ttgctcgatg cacttccgat tggcggagca acatgtgaca cagctggcat catcagtccg 1127101 gctgttttgc aggtagcagt ctttcaggta acagatgcac tgaaactgct gacgggagag 1127161 gagtgcgagc cggtgctgcg ctcctttgat ttgtggaaaa acgagcggtc agaagtgaga 1127221 gcggccagtc tcaaacatga cgcatgccca agctgcggca caaaggattt tccgtttttg 1127281 tcttatgaaa atcaaacaaa agcggctgta ttgtgcggca ggaacacggt gcagatcaga 1127341 tcatctatta cgaaagaagc ggatcttgaa gcgcttgccg gtcagctgag gcaggccggg 1127401 cttgaagtag ctgcgaaccc gtatttaatt tcctgccgct cggatgatat gaaaatggtg 1127461 ctgttccggg acggcagagc tttgatccat ggaacaaatg atattgcccg ggcaaaatcc 1127521 atttatcata aatggattgg gtaataaaag gagtgtagtg taatgagtat atataaagca 1127581 ttgacaatcg ccggatcaga ttcaggcggc ggcgcaggga tacaggctga tattaaaacc 1127641 tttcaagagc ttgatgtatt cggaatgtct gcgattacgg cggtaaccgc tcaaaatacg 1127701 cttggcgttc acggggtgca tccgctgact gtagagacgt tgagacagca aattgacgct 1127761 gttgctgagg atttgagacc ggatgcagtt aagacgggaa tgctctggaa tgccgacatg 1127821 attgaagaag tggcaagaaa aattgacgag tacggattca atcgtgtaat tgttgatccg 1127881 gttatgatcg caaagggcgg ggcatccttg ctgcgtgatg agtcagttgc caccttaaag 1127941 gagttgctca ttccaagaag ctacgcgatt acgccgaatg tcccggaagc agaaacgctg 1128001 acaggaatga caatcagctc gctggatgac cggaaaaaag cagcggagca gctcgtcaag 1128061 atgggtgcgc agcatgtcat tatcaaaggc gggcaccagc ctgaggacaa tcacattact 1128121 gaccttcttt ttgatggcag catgtttatg caaatcaccc atccttatat caatacgaag 1128181 catacgcatg gcacaggctg cacctttgct gcggctttaa cggcccaaac ggctaaagga 1128241 gacagcatcc atcaggcatt tgaggttgcg gccaactttg tccgtgaagc ggtggaaaat 1128301 acgctcggca tcggatcggg acacgggccg acaaaccatt tcgcttttaa acgaaacagc 1128361 ttaaatacaa gccgatgaga tcaccagctg atggtgatct cttttgcgtt tgctacggta 1128421 tgcgcttttc atctggacaa ggttatgata tgataggaat taagatcagg tactaatact 1128481 atgtctttat taaatatagg aggctttata catatgaatt tttcacttga aggccgtaac 1128541 attgttgtga tgggggtagc caacaaacgc agcatcgcct ggggcattgc gcgttcttta 1128601 catgaagcgg gtgcacgttt gattttcaca tacgctggtg aacgcctgga gaaatccgtt 1128661 cacgagcttg ccggaacatt agaccgcaac gattccatca tcctcccttg cgatgttaca 1128721 aacgacgcag aaatcgaaac ttgcttcgca agcattaagg agcaggtcgg tgtaatccac 1128781 ggtatcgcgc attgtatcgc gtttgccaac aaagaagagc ttgtcggcga gtacttaaac 1128841 acaaatcgtg acggcttcct tttggctcat aacatcagct catattctct gactgctgtt 1128901 gtcaaagcgg cacgtccgat gatgactgaa ggcggaagca ttgtcacttt gacgtacctt 1128961 ggcggagagc ttgtgatgcc aaactacaac gtcatgggtg tagcaaaagc ttctcttgat 1129021 gcaagtgtga aatatttagc tgctgactta ggaaaagaaa atatccgcgt caacagcatt 1129081 tctgccggcc cgatcagaac attatctgct aaaggcatca gcgatttcaa ctctatctta 1129141 aaagacatcg aagagcgtgc accgcttcgc cgcacgacaa cacctgaaga agtgggcgat 1129201 acagctgcgt tcttgttcag cgatatgtcc cgcgggatta caggtgaaaa tcttcacgtt 1129261 gattctggtt tccatatcac tgcccgctaa gcaggctgtt aatgatgcaa gggctgtctt 1129321 gctttctgta gcaggggata caaaaatctt gagcggttgg ctgttttgcc gcgcctgtta 1129381 gcagggcaag acaaatataa atgctgtttc gcccgggtca tggctacata taaaaggcgt 1129441 ctttcctcct caagagcggc ctcgtctcct tttcttgccg tttctaatga gaaatcgtgc 1129501 ggaatcgagc catctacagt gcctaacacg tagactgttt tgaattcaag gccttttgac 1129561 cggtgaatgg tcatcagctg aacgccatgt tcatccgttc tgtttttctc agcggccctc 1129621 atatggtcta cgtgggcaag aaagtcagga atcgttttga acttcttggc gacaaccttg 1129681 atgtcgcgca ggtcatcaga gcctttttcc agcttgttgc cctcattgcc ccgctttttt 1129741 aaatactcgg agaagcccat ttttccttct gcaaaggtga tggcttctac gggtttcatt 1129801 gtgcggaggc ttgcaaaaaa cggtacgatt ttcttgattt tgtccagctg gaatggcttc 1129861 agatcaggca atttggccag cgctttgatc atggtacagt cctctgtaat cgagagcgcc 1129921 ttcagcgtat tcaaagcgga ctgttttaaa aacaaggcgg gaagcaagtg tttaatcgcc 1129981 tcggtgtcat cctcattttg gctggcgtac aagtaggcga gaatctggcg gacgatccgt 1130041 ctgctgtaaa acgattggac gccgcggtca gctgtatacg gaattgacga ttgatgaagc 1130101 ctttcatata tagcacggcc tccgctgttt gtgcggtaaa gaaccgcaaa gtcttctgga 1130161 ctggctccat tttgaatttt ttctttgata tcggaaacga ccattgtggc ttcttcctct 1130221 tcatcataag gataaaacag cacagggacc tgaatgtcat cgcgggccgc ttcaagcgtt 1130281 ttggcatatc tgtttttgtt ctttttcaca acgatatcag cactagagac gatcgggtgc 1130341 gtagacctgt agttcgcagt taaatagatc gtcttcgctc ccggataatc cttttgaaaa 1130401 tcaagaatga aagacggatt gcttccgcga aacgcgtaga tggactggtc atcgtctccg 1130461 acacagcaca ggttttgctc cgggctggcg agcatttgca tgattttgta ttgaaccgga 1130521 ttaatgtcct gaaactcatc aattaagata tacgtaaacc gagattgata ttgttccaga 1130581 aggtcaggcc gctcgataaa caattcatag caggctgaag ccatgtcatc aaaatcaaat 1130641 tggctgtgtt cttttttctg gcgttcataa tgttcatata aacgataaac ttgtttttcc 1130701 cactcatctt ttagagggat gcgttcattt gggacataag tgtttttcca aaaaccgatc 1130761 tgctgcaggg cttggtcaac tggggattct ttctcatcga tgccttcttc atagagtgct 1130821 tttttgatat attgttcccg ctgccactcc attttcagca gatgctcacc gttccattta 1130881 gcagaattag agtgatacaa gatcttataa aacagactgt ggaatgttcc tgtcacaatt 1130941 cttctgactt ttgccggctg taatccgtac tggttcgcca tacgctcttt catttcagcg 1131001 acagcttttg ttgtaaaggt gacaagcagc atattttcag gcggtatgcc taagtgttcg 1131061 atcatgtggg cggcacgggc tgtcagtacc cgtgtttttc cgctccccgc acctgcaagc 1131121 acgaggagcg ggccctctgt ttccgtgaca gctttcagct gatccgtgtt taaaccgaca 1131181 gacggaaaaa ggctcgtatc gggttctatt gtttttggca caaatggtgt tcctggttta 1131241 atgcttctag gacggtgcca ttctgtaaca gctggggacg ggtcagcggc gatcgctttt 1131301 cccttgggta aacgaatgac accagattcc tgatcatctt cttttttccc ctctttagag 1131361 ggcttcggtt cgcacgcctc ctcacatgcc ggaaaatcgc ctggctggcg atggataaac 1131421 tctggcggat cggcgatgtt aagccgtaac aaaacgggct ttccgcaatg agaacaaaat 1131481 aaatgtcctt ttattccctc ttcaaagagg aattgataat gttctctcga atatgtatgt 1131541 aaatgtatga ttctatcatt cagtcgggcg catttcaaaa aggggtcctc ccaatcaaaa 1131601 ggtgttcatt acagacaatg actatcatat caaaagaaat gtgtttcaaa aagtaagttt 1131661 aagggaaaag agacagcaga ggggtgggta ttgtatgata tatgcaggtc aaattcagaa 1131721 ccagcaatac gctcaatatg ctaatagaac gattggacat aagcaggatt atgccggaac 1131781 cgaaaaaatc agctatgtcc cgtttcagcg ggtatacaaa gaactggaaa agcagcagga 1131841 gaatcaaacg gcagctgaaa gaaaagtaaa cgagatgaaa cgtaagcgct ctctttataa 1131901 gagattgcga gaaaaaggaa tggggacata tattaatcga tatgtataaa aaaccgttca 1131961 taccagagaa cggttttttt atatgcagta aaaatccgga tctcaaaaga tccggatgcg 1132021 ttcagtcctt catcatttgt aagtgcggaa tgccggcatc gaggaattct ttttcagaaa 1132081 gcacgcgata cccgtgtttc ttgtaaaacg gcacagcctg tgtttgcgcg tttaaaatga 1132141 aaccggaagc gcctccgtct gccgcggctt tttcgagcgc tttcataatg atgccgccga 1132201 caccggctga gcggtggctt ttcagtacgc aaatccgctc taacttgccg tagccgtcct 1132261 tcatgcgcca tcttccggca ccgacaggct tttcaccgtc atacacgacg atatgctctg 1132321 actcattttc aagttcgtca atttcttctt cagcaggcac gttttgttct ttgacaaaga 1132381 cttcttctct tacatagaat gcatctttca gttgttcttc attttttgcg ataactgctt 1132441 tcaaacatta ttctcctctg cctagcaaga aggtttcata tactgtccac gatccgtttt 1132501 ccaactggta gagcaagtgg aaacggtcaa cgatttcttc atgcgacact tcctgcattt 1132561 ttaattgtcc cagcacatct gaatgctcat cgtcggaaag attttggccg accgtcacat 1132621 gcggaacgaa attatattcc tgttctcctg ccaacacacc ggtgtatagc ttttcattga 1132681 gtgtttttaa ctcttccgtc ggttctgctt tgatgtaaat gacattattg acaggcgcaa 1132741 atgagctgta ttttgtcatt ttgagaacga gtgggtggga ctcttttgcg atgtttctta 1132801 aatgtgatac gagctgatcc gctttctcct ccgcgcattc aaaggatgct ctcagcgtca 1132861 aatgaggcgg gattagagag tagcttgggt catagcgctt tctgtaagag tttgcaaggt 1132921 cttggagctt ttttgatgga aataaaacga ttccgtattt catattatgt ccctcctgga 1132981 aataaagtat gatagagtgt taaagcattt ttttcagcgc cggggtgatg agcggctgcc 1133041 agtatgtcca tttgtggtct ccgtcaaatg gctcgaaatc ataatcggaa agctttttct 1133101 ccagcagctg tttcagctcc cggttcggtt ctgtaaagtc cagaatgttc ccgtctgtcg 1133161 tgtggacgtc agtttctttt gttccgattt ggtgataaat agagaggtgt ttgatatcgt 1133221 ctgactgttt tacggcttct agtacgtgtt tgtcaacata gggagactgc atgatgatgt 1133281 tgccaaacat attcggataa tcaagcgctg tcataagtga cacggttgct ccgagcgaat 1133341 caccgatcag cgttcggccg taaccgatct gataggttgg atactcatca tctgcaaaag 1133401 gaacgagctc atgggcgatg aaccgtttat aagccgaaaa ttttgaaccc tccggatgat 1133461 aagtgtttct gcgctctttt acatccttat agggaacacc gataataatg ctccggtcta 1133521 tttcgcgttt cgacagcaat tcctcaacct gtctgccgat tctccccagc ctgaaataat 1133581 cgtggccgtc ctgcgcgata atgacatggt atttataaag cggggagtag ttggacggca 1133641 gataaacaag caaggtcatt tcctcgttaa gctcttttga aaagaatttc ttttcttgca 1133701 ctgtgccgtt tttcggtgcc ataaaaacat tcctccagga catcactata ctttcttgca 1133761 ttttcaatta ttgtaccatg aattattaga aatttctctc tttaaacggt tcggcacacg 1133821 aagaaaaaag tgttgaaata aactgtgaat tgcgctaata taaaacaatc agaaaattga 1133881 aatcgatatt tcttatcgtg agaggtggag ggactggccc ttagaaacct cagcaaccgg 1133941 cttgttttgc atttgcaaag cgccaaggtg ctaaatccag caagcgtttt ttatgcttgg 1134001 aagataagaa gaagcgttaa accccttctt cttatgaaga aggggttttt attttgaaaa 1134061 gggaaggtgt cagctatatg tcacagcacg ttgaaacgaa attagctcaa attgggaacc 1134121 gtagcgatga agtcacggga acagtgagtg ctcctatcta tttatcaaca gcataccgcc 1134181 acagagggat cggagaatct accggatttg attatgtccg cacaaaaaat ccgacacgcc 1134241 agcttgttga ggacgcgatc gctaacttag aaaacggcgc gagagggctt gcctttagtt 1134301 cgggaatggc tgctatccaa acgattatgg cgctgtttaa aagcggagat gaactgatcg 1134361 tttcatcgga cctatatggc ggcacgtacc gtttatttga aaatgaatgg aaaaaatacg 1134421 gattgacttt tcattatgat gatttcagcg atgaggactg tttacgctct aagattacgc 1134481 cgaatacaaa agcggtgttt gtggaaacgc cgacaaaccc cctcatgcag gaggcggaca 1134541 ttgaacatat tgcccggatt acaaaggagc acggtcttct gctgatcgta gataatacat 1134601 tttatacacc ggtcttgcag cggccgcttg agctgggagc tgacattgtc attcacagcg 1134661 caaccaagta tttaggcggg cataacgatc tgcttgctgg acttgtcgtg gtgaaggatg 1134721 agcggctcgg agaggaaatg tttcagcatc aaaatgcaat cggcgccgtc ctgccgccat 1134781 ttgattcgtg gcttctgatg agaggaatga agacgctgag cctcagaatg cgccagcatc 1134841 aggcaaacgc gcaggagctt gcggcgtttt tagaagagca ggaagaaatt tcggatgtgc 1134901 tgtatcccgg aaaaggcggc atgctgtcct tccgtctgca aaaagaagaa tgggtcaatc 1134961 cgtttttaaa agcactgaag accatttgtt ttgcagaaag cctcggcggg gtggaaagct 1135021 ttattacata ccctgcgacc cagacgcaca tggatattcc tgaagagatc cgcatcgcaa 1135081 acggggtgtg caatcggttg ctgcgctttt ctgtcggtat tgaacatgcg gaagatttaa 1135141 aagaggatct aaaacaggca ttatgtcagg tcaaagaggg agctgtttca tttgagtaaa 1135201 cacaattgga cgctggaaac ccagctcgtg cacaatccat ttaaaacaga cggcggaacc 1135261 ggggcagtca gtgtaccgat tcagcacgcc tcgacttttc accaatcttc atttgaagag 1135321 ttcggggcat atgattacag ccgctctggc acgccgacaa gaacagctct cgaagaaaca 1135381 attgccgcac tggaaggcgg aacaagagga tttgctttca gttcaggcat ggctgccatc 1135441 tcaacagcat ttttactgct gtcacagggt gatcacgttc ttgtgacaga agatgtatac 1135501 ggcggaacct tccgtatggt gacagaggtg ctgacccggt ttggcattga gcatacgttt 1135561 gtcgacatga cggatcgtaa tgaagtggcg cggagcatca agccgaacac aaaggtcatt 1135621 tatatggaga cgccatcaaa tccgacactt gggattacgg atattaaagc agttgttcag 1135681 cttgcaaaag aaaacggctg cctgaccttt ctggacaata cattcatgac gccggcactg 1135741 cagcgtccgc ttgatctcgg cgtggatatt gtacttcaca gcgcgacaaa attcttaagc 1135801 ggacacagcg atgtgctctc aggtttggct gctgtcaaag atgaagagct tgggaagcag 1135861 ctgtataagc tacaaaacgc gttcggcgcc gtccttggcg tgcaagattg ctggcttgtc 1135921 ctgcgcggat taaaaacatt gcaggtccgt ttagagaaag cgagtcaaac agctcagcgg 1135981 cttgcggaat ttttccagaa gcacccggcg gtcaagcgcg tgtattatcc gggactggct 1136041 gatcatcccg gcgctgaaac ccataaaagc cagtcaacgg gagcgggcgc cgtgctatct 1136101 tttgagcttg aaagcaaaga ggccgttaag aagttagtcg agaatgtgtc actcccagtc 1136161 ttcgctgtca gccttggcgc cgtggaatcg attttgtcct atccggcaac gatgtctcat 1136221 gcggcaatgc ctaaggaaga gcgtgaaaaa cgcggtatca ctgatggcct gctccgtctg 1136281 agtgtcggcg tcgaacatgc agacgattta gaacacgatt tcgaacaagc gctgaaagaa 1136341 attgctccag tttcggttcg ttaaaaaaga agccggggat agtccggctt cttttattat 1136401 tgttcgtcat caggattcag aatcgcgagg acttgatgat cctcccaaac gccattaatt 1136461 tttacatttt ttcgggcgat gccttcttta tgaaatcccg ctttttctaa aacacgcatg 1136521 gacccgagat tacggggcat cacaccggct tcaatccgat gcagtttcaa ttcgtggaac 1136581 gcataatcaa caaccaatct gactgcctct gtcataatgc cctttccatt atgggctttg 1136641 tctaaaaaat acccgatgaa cgcagtttgc agcgcgccac ggatgatttg aaagagcgaa 1136701 accgtcccga ttaatctatc gtctgacgct gtaaagatgc caaaatgata ttcttcatct 1136761 ttctcaagtc tttcctgata ctcggttatt cgttttcttt gcccctcaac cgtatagtaa 1136821 tcgtctgcgc gtatcataga aaactgttcg aaaaaatctc gattttcgct ttgcagcccc 1136881 agattttctt cggcatccgt tacttctaaa ggtctaacat aaatggtttt tccttttaac 1136941 atatagtgat ctctccgttc tcatgtcagc attcctctta cattattctc agggaaatgc 1137001 aaatatcctt tttataagaa ggaagaaaac caatttccca taaaagtgcc aacatagttg 1137061 ccgattaagt agccgagcgt accgacaagc atgatcgggg cgacaagctc ccgccatccc 1137121 ttggcaattg ccatcgcagc cgcagtcgtc ggtcccccga cagtagcgtt gacggcgagc 1137181 agaatttctt caagccgcac acggaacaat tttccggcag ctaaggaaac cgctaaattg 1137241 ctaatcgcaa tgataaacac gaataataga ataagaggcg cattcgtgac gattaagcgg 1137301 agatctgcag gaatgccgat caccacaaaa aacaaataaa tcaaaaaggt tccaagctcc 1137361 tgagatccat tgagcctttc aaaaaaacgc gggaaaagaa aaatgataag aacagttaaa 1137421 gacgtaagaa ccaggtactg atcgccaagc gtaccggtca gcaggggatg agaaaaaatg 1137481 cttttaaaat aaccggaaac cttcatacta accgcaacaa gcgcgaaagc ggcaccggca 1137541 ttaaaagcga tatcctttaa ggaaatatcc ttccgtttcc aatagctttc agcactgttt 1137601 ccgctgtttc catcggcttt taccttctct tcaaacggca tggcataatg ccgctgaaac 1137661 catttgagtg caggaatgct gattaaaata aaaaacaaaa gcgccatcat aaaattatca 1137721 gccacaacgg tagccgacac atattcacca ggcgtctcaa attttgccgc catcgccgca 1137781 aagttgaccc cgccgccgat ataagaggcg ctgatcatcc caccgatttt atctaagtaa 1137841 ggaatatgct gtttgagtag aaaaaaagcc aggatactgc caagcactgt tccaacggag 1137901 ctaatcagaa aaataaacag caaacgcctg ctttccttaa aaatttgcct aacattgatc 1137961 tgaaacaata aaagtggtat cgccagcggt accacataag accacacagt gtcatacacg 1138021 ggcgactcaa caggaagcac tcctacattt gtaaacacca tagcacctgc aagggcgata 1138081 atagcgcccg acacagcaga cgcccactta aagcgctgct ccagcccgat gctcactgcc 1138141 gcccacaccg caataaaccc ccataatacc catacatcat cagaagaaat caaagaatgc 1138201 aaaaccccat cacctctatt gttagaaaat taagacatat tataatagcc ggggaacgga 1138261 acagcaagtc caaaaaaagt ttttctaaaa aagcagttga cgaatagaag gtaaggttat 1138321 ataatagaac ttgtcagaaa gataacaaca tacccagcaa cacatacata tcatgattcc 1138381 gtagctcagc tgggagagcg ctaccttgac agggtagagg tcgctggttc gagcccagtc 1138441 ggaatcatag cttaaaccct tgcgcagcaa gggtttttta ctttgcgtta ataaagccgg 1138501 ttcgtcaaat tcgtgagttg ttggcgaact gttggcgaaa ttcattgacc gcagtccaaa 1138561 aactacctcc aaacttactt gattagttca atagtaacaa acggaagatc ggatttctgt 1138621 taaatcttca ttgagaatag ccagtccaag accgtcactt cagccatgca tcttttaaat 1138681 gaaattttgt actgaaaaca tcaattgtat ttttaaattc tgctctagaa tcagcccctt 1138741 tataataatc ttgataaatt gcttggggtg atactgattc gtgatttgtg ctatggtttg 1138801 caaggcttgt agcaaaagca ggagcaacag taacgagtaa agcaagggat aatgcaaaac 1138861 cagttaaagc tttttcaatt tcattttaag cacttctttt tttaaaatac aactttatta 1138921 ttaaatggaa tacaaaaaca tccaaggtgt ttttttgtta gtaagttgag ttagggggat 1138981 tggatggcac ttagaatatt gtttctgctg atgggatgtt gattctggat atatttccaa 1139041 cacgattaca ggccggacat gaaagcgaac cttgctttga tcggggcaat catttcattt 1139101 acggctgcgg tttactttaa agatattgat gtattgagag aagagggaaa acaaatgaac 1139161 ggaatttctg agcgttggaa cacgtttaaa ttacaaaaat cccctgaacc actctagatc 1139221 aggggattgc tttcccaaca gcttattaag tagcggaagg catgatcaac gatttagtat 1139281 caatttatta attgcgaata ctagaaacat accgttttcc gccttcctta gaagtaacat 1139341 attctcgagg aacattaagt ctattggtag aatgataact tacataaagt ttcatatttg 1139401 ctcggctcgt tacgatagcc gtatgatcca tccaaccatc agcatagcga agacctattt 1139461 tattatggta atcatagtga tatacatctc caagctttac atttgaatat gtatcagaaa 1139521 cagtcttcat ttttattccg ccagctttta aaatgtatga tctaaaggct cctgcattaa 1139581 cccaagcatc tgtatagggt ttccattctt taaagtacgg cattcttcca gctcttaatg 1139641 cttgggaaac aaagttagta caatctttgt ctttataata tttatagttt ttatttggtt 1139701 ttaaggcata tttttctgca tatttcattg cagcgtaacc actatatcct ttaacagatg 1139761 ttgcagtcac agttagttga ttagagttag cagcattgaa gttcatactt actggtttat 1139821 cttcactttt cacttcttct ttatcatcat ttttcacttc ttgcttatat ttttttaaaa 1139881 attcatctaa tttaacatcc gaagaatatt cttcatcatt ttcatattgt agagttgaag 1139941 aagaattatt taattgtgtt acatttagtt gcttagaaga attactcaat ggtattacat 1140001 ttagttgatt agaagaattt ttaacttgag agaaacttag attagaagta tttgttgatt 1140061 gagaactttg tttattagaa gttgttttgg gaatttcaag tttaatatta tcgcccagag 1140121 atgttgttac tttttcaaca ccaaaaacaa agtttcgagt aatataagct tcaacaatta 1140181 gcttattgtt tttttcagaa gtcttaacat cgtctatatc gtatgtaaac tcgtggaatt 1140241 tttgtttgtc cactttactt aacgcagaat acagtaagac tccttcgtcg gaatcagtca 1140301 atttagactc tttaggatgc gctaaaggag tgttgtgttc aaaatcatat ttttgttgtt 1140361 ctaacatatc cttaactttt tcgtaaccaa tctcgttggt aattgaaaca ttttctttag 1140421 tctctttatt agtagtggct gcaaaaactt catttgttga cactaatggt gacaatgata 1140481 gacataaaac tagtgaagca agtaattctt ttttcatacg aaacctccaa taaaatctaa 1140541 atataagtaa tatttatcat ttacaccaat tgaaatatgg cataaaatac atgtaataat 1140601 ataacataaa aataaataca taaaaaggta tcggaggaaa aaatgaaaaa gaaaactaaa 1140661 attatacttt ctctcttggc agcacttatt gttatattga tagtacttcc agttctatct 1140721 cctgttgtct ttacagcttc ttcggaaaaa ggagcaatca gacacgaaat ttataaaaga 1140781 ggatatccct accaaagcta ctttgcagtt ctccagaaaa gagaaggaga caatgaatct 1140841 gggaatcttt attatgtaaa ttggctagat tggaaagatg aaacagggca aactcctcac 1140901 ttatgctatt cgaaaaaatc atcagatggt gaatacgaag taagttgtgg cacagggccg 1140961 taaaaataaa ttttaaaatt gaataagtcc aagacggaaa gcctgcggac actgatcgtt 1141021 ttacagagaa atttgtgctt cgatcggtgt ccgttttttt tcgcaactaa ccagatgtct 1141081 atcgcgatta ctagctatga aaggagtaat tagacatgaa acagtccaaa aagaaaccat 1141141 cacagaagca acatgagcgc ttagatcgtt tctggcaaca aatgatgaac actaacatgc 1141201 aaacactcag acgtggcaaa ggcggcgctt ataaacgcag aaagtaaaaa gggagtttga 1141261 ggatgatgaa aaacggattc gcttataaaa acggaaagct tgtgaatatc ttttgcggca 1141321 aagaagagct ctataacgag ttgaaagcct tcttggtcaa aaccttcagt atcaacgtga 1141381 aagaggtatc gaggccctca atatatcgca gaacaaaaag caaacaactg gaatgacact 1141441 tactctattt aactatcagg agggaaagca ctatgacaga tcaaatgatt gcatgggaga 1141501 ttgaggaatg gattcgtgat tataaattca tgctgcggga gatcaaaagg ctcaaccgtg 1141561 tattaaacaa agtggatttt attagcacaa agctcactgc aacatacggg gaggaagcgg 1141621 gcatgccaag gggatcagca ggcgtcagtc aggcagaatt gcggcagatg gaccgaagag 1141681 aaaggcggct tcacaaatat gaatctattg tgcattacct ggacaatgca atggaacaca 1141741 ttgaagaaga aaagcaccga atcgtttacg attgcatgat ggaaggcatg agctacactg 1141801 ctattgcaaa ccaccttgat tgctcccggg ataccatcag aaagatcaaa acagccataa 1141861 tcggcaacat cgtcaataaa gtcaaagaag ccaactttct gcaatatttg aattcgttta 1141921 aatcggcggt gtaaaatggg gggcaggatc ggcgcggcgg attattcctg cgtcaccacc 1141981 aatttcatac aatgagtaaa acctcccagt ggtaagcgag gatcaactca actgggaggt 1142041 cttacatagt gaatcggtga taaaacagca gcagtattgc gtacatgtta atatccccga 1142101 caaaatatgt ttttttcaac agattcgttc gacaaatttt gcaaattgtt aatcgataac 1142161 ttttcattcc cgatattaaa aatgggagtg aattgtaaaa tgaaaaaaca gaaaaataat 1142221 aaaaagaaga atattgaaaa gcgaaatatt gaaaagcgaa atattgaaga gaagaataat 1142281 gaggacttag aagaactgga aaatgcgatt tatacttatc acaaaaagga gctacttgct 1142341 ttctttcttg aaaaaactcg aattggtcat gataaggaag aatacaaaag gttccaatct 1142401 cttctttata agttggatat tgaatgttta gaatttgcta tatcgagatt ttctcatata 1142461 gatattatcc atgatcattc aaaatatgtt ccagccttta tccctttatt tgcagcatat 1142521 ctcaccatgt tctttaattt ttatgaaaaa cattggggag ctttatcttt tgctgctggt 1142581 acaattgctg ctattgtttg gataattgca gtagaaagaa aacatagaaa tcaagcaatt 1142641 tctattatga aaatatttga acaagtcaaa gagagaaaag tgaaagacag atctaaagac 1142701 tgaaaggaga aaatatgaat aaggataaat taaggtatgc aatcttaaaa gaaatttttg 1142761 aaggtaatac ccctttgtca gaaaacgata ttggagttac tgaagatcaa tttgatgatg 1142821 ctgtgaactt tttaaaacgc gaagggtata tcattggggt ccattattca gatgatagac 1142881 ctcatttata caaattagga cctgaactga cagagaaagg tgaaaactac ttgaaagaga 1142941 atggaacatg gtctaaggcc tataagacca ttaaagagat taaagattgg attaaataat 1143001 aagagcatcc tgcggggtgc tttttttgtt ccctgtaaac tgcttccggt aagtctcagg 1143061 atagacaatt ggcggttaac ggcttgagca cggtggtggt ttagagggaa tatcttttcc 1143121 aaaacaacac gaatcagaag ggggcggcgg tgaatgtaga tggccgaaaa gcacattcag 1143181 gcgtataagg attacgtcaa aggcatgaaa tacaaggacc ttgccgagaa atacggggtg 1143241 tcagtgaaca ccattaaatc gtggaagcag cggcatggtt gggaaaggaa aaagggtgca 1143301 cccattgaaa aaagtgtgca cacaaaaaaa ggcgggcaac cgggcaacaa aaatgcatta 1143361 gggaacaatg gcggcgcacc acagaagaat caaaatgctg tgactcacgg ctttttctct 1143421 aaattcttgc cagaagagac gcttgaaatc atggaagaga ttcaggagcg ttcgccagct 1143481 gatatgatat gggatcagat acagattcaa tatgcggcca ttcttcgggc gcaaaagatc 1143541 atgttcgttt ctgataagga agaaatgatc aaagagctga aaaagaaaag gtccctcata 1143601 tctgaggtca gcgaaattga agatgggctt gtcattagtt ttagtacgtg gtttcgctac 1143661 agactttaca gtgaaacaaa cacctaacac atttcacatt gcttcagatt gccttcaaac 1143721 ttgataatat aacttctaaa ccttcctata aaatgaaggt tttttatttg atttcaattt 1143781 ttaaatcctt tacatacagc gattgattaa ctcgagcaat caatgtcgca gttatattta 1143841 tttttcaaga aaatgttata atgaaaagcc ataaaatgat gggaggggga atttcgatgc 1143901 attacataac ggcatgttta aaaatcatca gtgataaaga ccttaatgag ataatgaagg 1143961 aattcaaaaa acttgaggaa gaaacgaaca aagaagaggg ttgtattaca ttccatgctt 1144021 atccgcttga gccatcagaa cgtaaaataa tgctttggga gatttgggaa aacgaagaag 1144081 ctgtgaaaat ccatttcaca aaaaaacaca caatagacgt tcaaaaacaa gaattaacgg 1144141 aagtagaatg gttaatgaaa agcaatgtga atgattgaaa ggctctttaa aaagagacat 1144201 tcaatgactt agtatcagcc acttgtgact aagtagtaaa ttgttgtcca actcttattt 1144261 tttctattta atattttttg agacgaaaat gtttttttaa gctgatttta aaatgtattc 1144321 aaagtcagct ctgtttgatt taatggatta tattatttgg atagcttgtt accatcataa 1144381 tggagatact ccttataaat tggaggttaa aataatgagt cattctcaag aaaaaattgc 1144441 actaattaca ggagcaagca gtcaagggga tattggtacg gctatttgtc gtaagttagc 1144501 ctcacagggt atacatatct tctttactca ctggaattct gatacggcct ggatagaaga 1144561 atttcaacaa gaaattttac gtatgggtgt ccgctgtgag gcaatgaaaa ttgatttatc 1144621 agatgcacat gctgcattca caatacatga aaaaatttca gataaattag gatatccttc 1144681 catccttatt aataatgcag ctcattccgc aagtgataat tatgtatcgt tagatgctaa 1144741 atcacttgat gagcattatg cggttaatat gagatcgaat tttcttcttt gtgttgaatt 1144801 cgcccgtcgg tttaaaaaat ctaatttaat atcaggaaga atcatcaata tgacatcagg 1144861 gcaggattta ggtcctttgc ctggggagtt agcgtatgca gcaactaaag gagctatttc 1144921 tgcatttact aggtcgttat cacaagaact tgcaccattg ggcatcactg ttaacgccgt 1144981 aaacccaggt ccaacagatt ctacatggat gacagatgaa ataagaaatt ttctttcacc 1145041 taaatttcca atggggcgta ttggcacacc agatgatgca gcacgaatga ttgcctttct 1145101 tgcaagtgat gaggctgaat ggataactgg acaaattatt cattcagaag gtggatttat 1145161 tcggggctaa gctaatgaaa cacggtatac accaatgtat gatgtattcc caaaactaaa 1145221 tctaaacttg aagcgaaaat aaggtccctt ctctttttag agggggacct tattttattc 1145281 atgcatgttt tgcatccaga aaatctggcg gataaagatt aataaaccgt tacatatact 1145341 tttccgaata ctgcagtacc tttaaacaaa gtaatcgtgg ctttcccttt tgatttagcc 1145401 gtcactaaac cattttgatc gacttcagca actttttggt tatcagtcca ataacgagta 1145461 gctgaattat ttttaacaga ataggtttct ccaactttta gaggtaaatt atagtcttga 1145521 atcttgataa catgtgtagg tgaaatagaa atgttcttta cttcagtagg tgtggagttt 1145581 atttcatgag ctgaagctac cccgctgacc gacagagcta acgcagaaat cgataaagca 1145641 gaaacaaccg tttttttgaa attcattttg aaacactcct ttaaagtttt ttgtcttgca 1145701 ctataacaat tcaataaaag taattatttt ccttgtaaat aaatgttaat aatatgtgaa 1145761 cgatcaattg atttgagcta agaatattgt gtgccctgca cagagtttgt atttatgatg 1145821 gaaaattgct gagagagaat ggccatcctt aaaatgttaa tagcacacat ttgatgggta 1145881 ttagtttgtt gagcgtgtgg aaattttgtt acctgcactt tatccccgaa gataccaaat 1145941 cacttttctt catcatgttc ttactttcgt actcatacat tagaaaatct tcgttctaaa 1146001 taggtgaaga attggagtat ttttatgaat ttctgctgaa tatacattac atagcaaact 1146061 caaagagtat aaaaatcgct tttttccgga agcttcggta aaaaacgaaa cttttgtctc 1146121 tatgattttg ttttataatg taaacggttt cttatatagt atacttatac tatcaatttg 1146181 ctcaagtaga tactgacagg aaggatagaa aaacagatgg aatacataaa tacaagacaa 1146241 aaagagattt tgtatctgtt gttatctgaa cctgatgact atttagttgt gcaagatttc 1146301 gcagataggg tacagtgttc tgaaaaaaca atccggaatg atttgaaagt gatcgaggat 1146361 tatctcaatg agcattctca tgcacagctt attcgaaaac cagggttggg cgtttattta 1146421 catatagaag aacaggaaag gacctggcta agccaacaat tacatactga acatttttct 1146481 tctaggcagc ggagcgataa ggaaagaatg ctgcacattg cttatgactt attaatgaat 1146541 ccgaagcctg tttccgcaaa agacattgcc gctcggcatt ttgtcaatcg atcttccatt 1146601 aaaaaggatt tatacgcagt agaagagtgg ctgaagcgtt ttgatctcac actggtttct 1146661 aggcagcggc ttggattaaa ggttgaaggg aacgaaagaa ataaaagaaa ggcattggca 1146721 agaatatctg atttgattca caatacagcg tttaccagcc aatttattaa aagtaagttt 1146781 ttacattatg aagtagactt tgtgacgaaa gaaatcaaat cactacaaaa aaagcattcc 1146841 ctctatttca cagacgaaac gtttgaaagt ttgttgctgc atacattgtt aatggtccgc 1146901 cgcatcaaaa tgaagcagcc gatttcattg tccccaaaag aaatggcggc agtaaaaaag 1146961 aagaaagaat atcaatggac atttgcttgt ttacagcggc ttgaaccggt ttttgcaatt 1147021 cgcttccctg aagaagaagc cgtgtactta acattacata tattgggcgg taaggttcgt 1147081 tatccattgc agacagaaga gaaccttgaa aatgctgtgc ttcctaaggt tgtagggcat 1147141 ttaatcaatc gtgtttcaga gctgaaaatg atggattttc acaaggatca ggatttgatc 1147201 aatggtttga acattcatct caatactgtg ctacaacggc tgagctacga tctttctgta 1147261 gcaaatccta tgctcaatga catcaaaaag atgtaccctt atttgttcca cctcatcatt 1147321 gatgttttgg aagacatcaa tcaaactttt gatcttcata ttcctgagga agaggcagca 1147381 tatttgacat tgcattttca ggcagcgatc gaacggatgc agggcagcag cgagacacat 1147441 aaaaaggcgg ttatcgtctg ccacatgggg attgggatgt cacaattgct gcggacaaaa 1147501 attgaacgga aatatcacca aatcgctgta atggcttgta ttgcaaaggc cgatttaaag 1147561 gattatatca aaaagcatga ggatattgat cttgtcatat ccaccattgc gctggagaat 1147621 ataacggttc cccatattgt tgtgtctccg cttttagagc ctggcgaaga gaagaaatta 1147681 agtgcgttta tacgtcagct gggcgaatca caccgccaaa aacaaaaaac gtttcagatg 1147741 ctgaacaata cgactccttt tttggttttt ttgcagcagg aggcggagca tcgctacaag 1147801 ttaatcgaac agctggcgac agctttgttt gagaaaggct atgttgataa ggactatgcg 1147861 gttcatgcgg tgatgaggga aaaaatgtcg gctacaaata ttgggtcagg cattgccatt 1147921 cctcatgcaa acgctaaatt tattaaacaa tcagcaatcg cgattgccac attaaaggag 1147981 ccgcttgaat ggggaaatga aaaagtttcg ctcgttttta tgctggctgt caaacacgag 1148041 gatcaaacta tgacaaagca gctgtttagc gagctttcat atcttagcga gcagccggcc 1148101 ttcgtccaga agctgacgaa agaaaccaat gtcatgacat ttttatctca tttggattat 1148161 taaaagcagg gattattcct tgcttttttt gttcatggca gggcttgaga aataaatttg 1148221 cgagtgaaga cgcctattct ccagcaatga tctaaataaa ataagagttt aatagttgga 1148281 gaagaaatgt tacactcttt tctgtatatg gtaaagaatg aaaaaacacg attcggttgg 1148341 tagtccggat gcatgattga gaatgtcagt aaccttcccc tcctcgggat gtccatcatt 1148401 ctttaatatc ttttatgagg agggaatcgt tatgaaatta acgatttact acgatggtca 1148461 gttttgggta ggcgttgttg aagttgtgga caatggaaag ctaagagcct ttcgtcatct 1148521 ttttggcaaa gagccgaggg attctgaagt attagagttt gttcataacc aacttttgaa 1148581 tatgatggcc caagctgagc aggaaggagt gcgtttacaa ggcaggcgtc aaaaaaagat 1148641 caatccaaaa agattgcagc gccaggtttc aaaagagttg aaaaacgccg gagtaacttc 1148701 taaagctcaa gaggcgataa agctagagct tgaagcaaga aagcaaaaga aaaaacaaat 1148761 aatgaaagaa caacgagaac atgtaaaaga gcaaaggtat atgctcaaaa agcaaaaagc 1148821 gaaaaagaag cacagaggta aataatccaa acaaaagcag gcgcagtgcc tgcttttgta 1148881 attaaggact ctactttgta acatatatcc aatgtttata ctccgctgat ttatgattca 1148941 atataaaccc taacttctcc aaggtttttt gtgagcctag attatcatgt tcgcatcttg 1149001 cggtgatccg ggatactgtt tctcggctta atgcccagtt tattagtttt tgggcggctt 1149061 ccacacaata acctttgcgg cgatgacttt tatttgttgc aaaaccgatt tcaatcatgc 1149121 cattttcgtc tgggtcacct aaaaatccag ttcccccaac aatttcataa ttgtccttct 1149181 ttacaataat ccatgaatca aatccttttg ttccattgtt tttgactaaa atctcgcgga 1149241 aataaggtat cgcttcaaaa aaatcagaat ttggccattc accatttgtt tcatagccta 1149301 attctttgat agcctgatga tcttgtttag acgcggcgtc aagaagggga atatcaatcg 1149361 tttgtaatcg taatcgattc gtttcaagga gaaccatata tttaatcctc ttttcttttt 1149421 actgggaata atgataacat ataacaattt tctctggtac cttggcagta gagaaagatg 1149481 aaaaaattga gggggattga aagagtgaca ggtgagagtt tgcccagacc aaaaacgggt 1149541 aggaaaatgc tgatgttaat gtgtccctac ccgtttttct gttcctgaat gcagggtttc 1149601 tgataacatg ttgtgctacc ttttcgcaat caaataaagc gatatggctc tttgggtttg 1149661 cacaggatta tgaatgataa tgacccattg gtttcttcgt cttggaaagc ttgctaccgc 1149721 atacaatgga gcagtatcgc gcggagtgaa cccaccattt atcacgttga tatctcttcc 1149781 ttcaagatga caaactaagt attcacctgg attgatgacc tgttggttcg tccatgcgta 1149841 agaataaaag ccgtctccaa gatcttcggt ggaagatggg gggacaaagc catctacagt 1149901 caatgtgatt tctcttcttc gctgtctttc tgaaaagtct ggacttcttt gagggttatg 1149961 agtatgtgaa aagtaaggaa ttaacgcagg gccataaaag taatgataca aagcaaccac 1150021 tcctttattt tccattcata caaattgtat gtgggagtta tttgttcatt cctgttttgt 1150081 tccatgtaga ctaataatgg gctataggcg tccaaggaaa tcaatttgtc cttccgttga 1150141 ttcaatgcta gtaaccttga aaatgcaggt taggatgata gaatttacat attactgcaa 1150201 gaagttagac atacatcatt ttgatagtgg gtgaaaacaa tggcgaaaaa aatggcaaaa 1150261 acaaatgcgg ttcgtctgat agaacagcag aacatctctt atgaggtatt agggtataaa 1150321 acagacggcc agccggtaga tggcatctct gttgcggaaa aaatcggtta ttctttgaaa 1150381 tatgtatata aaacgttggt tgcagcagca ggaacaaatc attattatgt ctttgttgta 1150441 cccgttgcag aagagttaga tgtaaaaaag gcagcaaagg tgacagggga aaagaaaata 1150501 gaaatgattg caatgaagga gctgttagcg gtaactggct atcttcgcgg cggctgctcg 1150561 ccaattggca tgaaaaaatt gttcccgacc tatattgatg catctgcaga aacgcttgat 1150621 tttattattg tcagtgcagg gaaaatcggt atgcagctaa agttggcgcc acaagattta 1150681 gccagatcat gtgatgccgc atttgcagaa attgtataga tgcagatata ggggaacgaa 1150741 aaagcttagt catatcgatt aagctttttc cgcatccctt tcaaatatga tttcaaaata 1150801 agcagctgcc ccatacccat ctatactggg agcgaaaatc tgaacgaatc tccagcctct 1150861 tttcgcataa tcatggatga tttgctggta gtcttcttta ggccttcttc tcatcgtact 1150921 cagctcaact cttacgaatt catattcttt catcgtttga tccctcctat taaggtatac 1150981 gtaaaatgga gcgagaagtt ccgaaaacct aggttaaggt cggaaagtat atttcactca 1151041 ctaaacaaat ccatttatgc ctgatgcctg catgcatctg ggaagagtta aggggctata 1151101 aaaacgaatt ttaccgggtc agcagtccaa atgaatctct tgcttattgc atttgactga 1151161 gtatataagt aaaaaaagag cggccagaac atataagaag gagatgatca ttaacgcact 1151221 cataacaggg tagtgtttag cggagtagat gaaaaaatca agctgtgaaa tttgtttggg 1151281 gctgctgacg gcatcaattc cattaagcag ttttgagagt ttagcagtat agttccaatc 1151341 aaatcgatct gaaacaagct cgcttccttg ataccaatta acagcagcta aaaacagaaa 1151401 taccataata gaaaatccaa gctgaacaac taaaaatatt cccttcactt ttgtatgacc 1151461 tccaaatcta tgaatatggg aaaatcaaac aatatattac caccgtatgg gttattcttg 1151521 caatttcact tccatacaac tcaaacgcaa gtctattttt ttgtttgttt ttggcttata 1151581 atacctgatg atggaaaaag agtgcgggtt tatagattag agaaacaaat gtatttctta 1151641 gcatttttta tttgtggaga gagtatagaa gcattcgatt agatctgctt tttcacagaa 1151701 acggttttca tctgtttgcc tgagctttac aattggctgg caaaaaaaca atgatttctt 1151761 tcaatcaaaa catgcaacga tgcgacacat tttatatctt gatgacttat ttcattgcct 1151821 ttaagtcatc ctatcgagaa agcgatggta ttttatgaac aaagaaaccc taaaaaacat 1151881 actcatgatt ttttcaatat gcgcaacact ccgagaaacc gatggtatgc gcatagctga 1151941 tagctggatt ttgagtgaga ttatacgatt tttgatttgc atggttgtgt tttttgccat 1152001 gacatttcta ttagatgctg tttttccaaa caaaaaagag tcacattaat gtgtggctct 1152061 ttttgcatca tctgatcaga aacatcataa atgaatcgat catcatgatg aagaacagca 1152121 agcaaaaata aataagcgag tagacaaaca tatcctttgc ccacttcacg tcatcgtctg 1152181 ttttgaatcc tttgatgctt tttttgatcc atatgcctcc gagaaccaag gcggctaaga 1152241 aataaaatgg gcttatatgg ccggtgccga gagagaaagg aaataatagc gtgaccggca 1152301 ccaggacggc aatatattgc atcattttta tttttgttac atgattgcct ttgactactg 1152361 gcaagagcgg aacgccagca gcgcgatatt cctctttgcg tcttatccca atcgcccaaa 1152421 aatgcggcgg ctgccacaga aacataatcg tgtacaacag cactgctgtc atactgaagt 1152481 caccggttac ggcacaatac cccatcaatg gcggcgcagc tcctgggaag ctcccgacaa 1152541 atgtgctcca cacagacgtt cgtttcaccc ataccgtata gatgatcgca taaaaaataa 1152601 aggcggccag tccgagaaag gccgttaatg gattgaggga ataaagcatg gcaagacctg 1152661 cgattcctaa aacagagcca tatgttaaga tcatggctgg cggcattttc cctgtgaccg 1152721 aggccctgct gcgagttcgt gccatttttg cgtccatatg ccgatcaaaa tagttgttat 1152781 agacagtgcc ggaagccatc acaaacgcgg ttcccaacat tgctgttacc attgtcatca 1152841 aaaaagccaa gccggttaac gttttttctg cgcttgcaaa cgcgatccaa aacccgccga 1152901 aggctgctat cgagtttgat atgataatgc ccggctttgc aagtttgata aaatcgtaaa 1152961 tggttacccg gttcgaagct tttatgtatt ttgtttcaga tatggctgca gaatctcttg 1153021 tattctccaa aaatagacgc ctcccccaaa actgcatgct tttgttatcg taacaagagg 1153081 gggacagaat cacaattatt tcccatattt gtcatgatat tgtcattttt aaaacaaaaa 1153141 aatggggagc tggactgccc ccattttgat atgtggcgac tagtaaccgt aacctccccc 1153201 atatcctccg ccataacctc cgccgtaacc gtaccaaggg tagtaaggcg gtcgcgggcg 1153261 cgggtagtaa taaggcgggc gcggataaaa cgggtagaac ggataatacg gtcttggata 1153321 ataataaggc ggataaaatg gcggtctcgg acgcggataa taataaggct gtctttcatc 1153381 ataaggggta atttgttcaa atgactgttc attcaaaggg taatccaaga ggaaaacctc 1153441 cctagctttt tttattcctt ttaccatatt cctgatgctt aagttgggtg tatgtacatt 1153501 catgaaattc ggtttttttt atgatgaaat tccttaaaaa ggattgacat gaacttctaa 1153561 atctcatagt attacaaatg tgaaataaat gttactacaa tgttacaaaa acatttctaa 1153621 atagatacag ttccaactga tgaagagtaa atcgaaatgg ctacgaaaga aggagttttt 1153681 gttgttggca aaaagaatca aatggtttca tgtattaata gcagttgtat gtgtggtggg 1153741 ccttatcggc tttttccata atcattcatt gaaaaaagaa acggtcatga ataaagtaag 1153801 aactgattct caatatggga atgttgagat cgcaacgctt gtgaatgacg ggaaaacttt 1153861 taattacgcg gtaaactatc ctgttttcaa aaatgaaaaa atggattcgg cattaaaaag 1153921 attcgcagaa aaagaggttc gtcaatttca aaaggaaaca aaggacgttg accaagagca 1153981 tacgacaaaa cgcaacgaat taaatgttga ttataaaatt gtccattatg ccaaacagac 1154041 agtggcgatt gtatttaatg aatataaata catcggcggg gcacacgggc aaaccgtgaa 1154101 aaaaacgttt aactatgatt ttagtaaaca agcgtttctt tccattgatg atattttcaa 1154161 agaggacgct gactacttac ataagctttc gttaatcgct tatcacgagc tgaaaaagaa 1154221 taaggacatt gccgcggacg atgcactgtt aaaggaaggg acggctccga aaaaagaaaa 1154281 tttcagccgc tttgccatca aggaggatta tatcgaactt tactttgaca catatcaggt 1154341 tgcagcaggc tatcttggag agcaatcgat tgccattaag aaaagtcttt tgaaagacat 1154401 tctgaaagaa caatatattg ataaagcaaa aaataaaaat aaaatcaaag aacaaaagcc 1154461 gaagcatgaa gtgatttctt tacccaaaga ggaaacagtt gatccaaatc aaaaagtcat 1154521 tgcgcttact ttcgacgacg gcccgaatcc tgcgacaaca aatcagattc tagactcctt 1154581 gaagaaatat aagggtcatg ccacgttttt tgttttgggg agcagagttc aatattatcc 1154641 ggaaacgcta ataagaatgc tgaaagaagg aaatgaggtt gggaaccatt catggagcca 1154701 tccgcttctc acaaggcttt cagtgaaaga agcgttaaag cagatcaatg atacgcaaga 1154761 catcattgaa aaaataagcg gatatcgtcc gacgcttgta agacccccat acggcggcat 1154821 taatgatgaa ctgcggagtc aaatgaaaat ggatgttgcg ttatgggatg ttgacccgga 1154881 agattggaaa gaccgtaaca aaaaaacaat tgttgaccgt gtcatgaatc aggcgggaga 1154941 tggaagaacc attttgattc acgatattta ccgcacctct gctgatgcgg ccgatgaaat 1155001 tataaaaaag ctcaccgatc aaggctatca attggtgaca gtttctcagc ttgaagaggt 1155061 taaaaaacaa agagaagcga aataaattag aaaaggctgt ccgtacggac agcctttttt 1155121 ctatttaata agagcctgtg gtggcccaaa catttaagtt tggtcctgaa tacttgccga 1155181 aagcgtaaga agtccttgga tctaaatcat ataccatcgg tgtatagcaa gacttttggc 1155241 cggccaccgc ttttccattg ccgcctgcag aatcacaatt atatcttttt ccgtctgtgt 1155301 tccgggtaat ctccgcattt gcttcatagc cagacgtcaa tgtattattc atcgtgattt 1155361 ttgcccaagc cgttttacat gtactgctga atttaagctc gactactccg atgacttgat 1155421 tgctggcatt cactaagttt gaggattttt ttgtagagcc gctggacgca caatcattgt 1155481 aataagggct ttttccatcg taggcatggg tttccgcctt ggcgggtgca cctttgacgg 1155541 caaaaacaaa tactactgcg aataacacca atgaagcctt cataaacagt cttttcaatt 1155601 tatgacctcc ttaatatggc aaacaataaa tcatatggag gaacaatcaa aacatgcatg 1155661 cttttttgtg aacaataaag gcggccggga ggatggagtt cttggccgcc tctggtatga 1155721 ggttatgctt ttacatcaat ggtttgtccg agagttggat gttgaatcat ctttaaggtt 1155781 tgatcggcat tttgctgggc ggtgtccagc ctttttttcg ttaaagcaat atttacattc 1155841 tgggcaaggg atgcttgatg catcgcaacc gataaagcag gaatatccat ggttccacct 1155901 cctatgcctt acctatcggc gggtttgtat gattttacag tgaaaaatgg cttaatttct 1155961 cttgttgacc cttacgctgc ggcatatcgt atgtttttga caaggaggga atcaggatga 1156021 atctagtaat ggaaaagacc tttgagcaat acgaaaagct gttttcaatg gaagaacaga 1156081 aaagagaaga tgtatttcgg tatacgatga tgaggccgtt tgaaaagatg tggaccgcca 1156141 tccaagttcc gctgaaagcg aaggagccaa acggctatga tgtgatcatg gctgcgaaaa 1156201 tgctgggcta tttggatgtc cgtgatgctg aaagcggcca gaaagcacta caaatactga 1156261 aagaatcaca tgtttcagag acagctgaat ctgcacttcg gcaatgcata ttttttgctg 1156321 agcgcgaaca gctgcgggtg aatgcaaagg agatcaaatt cggcctttat atcgctgatc 1156381 caaataagct tcagctgcaa aaaggctact gcgggtttgg cgggataccg ggctttattc 1156441 atgtatggat taatccgaac agttataacc tgccaaggat tccttccatt attgctcatg 1156501 agtttcatca taatgtgcgg ttttcgtata tagattttca tcatggctct gtaagtgtcg 1156561 gggattatct tgtgattgaa ggattggcgg aatcattcgc cagagagctg tttggtacgg 1156621 aacgattggg cccttgggta actcgttttg atcatgaaga cttgcaatat tccattgatg 1156681 tgattaatga ggtgctggat gtgaaaggat tttcggaagt cagccgttat atgtttggtg 1156741 atccaattgc taacgaccaa ggctttaagc ctgcaggttt atcggctttt gcgggttatg 1156801 cagttggcta tcatgccgtt cagtcattta tgaatcaaca tcatatcacg ataagcgagg 1156861 ccacacgttt ggatgcgaag accattattt ctcaatgcgg tctgttttct acatgaaaaa 1156921 agcgtcacat acagcggcgc tttttgattc ccaaaaccag cagttctatg gcggcacagg 1156981 cggcaattcc gattgtatat gcttcgatat cgctccataa aaaaccgtac cctagtacaa 1157041 gcccgccaag agaagtatct ctaatctggt cgatccattc ggcatgatag agctggctga 1157101 attcaatgac aaaacagaaa gaaagactga taatgcccgt tatcattgtc ttcagcttcc 1157161 gaaatagaaa tccgcatccc gtgaagatca tggcggccca caacgagtct cccagataag 1157221 tattgagggt atcaggaaga acactggaga atgctctgga tccaagcccc agcccaatga 1157281 tcagtatggt gaaaactgca tatatccaac gatttcgctt cattgcgaat tgataccccg 1157341 tctctgcttc atctccctgt attgtaagga atatagcttt tatttgtcca ctaaaaaagc 1157401 ggctgaatag ccgcgtaggg tgtttatttt gcttttaggt ttacatggtc ggctgtctga 1157461 tccgtgccta ttacaaaatg gagttcatag cggcctgtat catatacata atcgatttca 1157521 tcggtaaacg ggacggttaa cacccgattt actggtccta attgcttctg cagcacttcc 1157581 ggcgtaactc cgcctaaatt cagctgccgt tccacaccgg ttccaaagta gcggatttct 1157641 gaaattgtca tgtctttatg ataggaaaat ccgtagcccg gctgtcccat attccagtga 1157701 tataaatcaa atcgattgtc tcccccgact ggtctttccg gttccccaaa cgcagcgtgg 1157761 acatcccctt ttgtgctttt gttaatggta aggccttgcg cctgctgagg catttcccct 1157821 ttataggcgg tgttatagag gtttttgaca agctcagcgg ctgattgatt cgtgttttct 1157881 gagagtgtgt ttgtttgagc tgcggccttt gccggtgctg aaaaggacgc agccccaaag 1157941 ccggtaaaac agcttgttac tgctgctgcc gcggttatag cagacattgt ctttttcatg 1158001 ttaatccctc ctaattgatc taccattccg tttccccgtg tttttgcaac gaaacatgtg 1158061 agtgcgcttt gtatgtttta ttgagttgtt gtaagggaac tgaaataggt aattcggtat 1158121 ataaagcaag aaaggggaat ggagatggct ggcaagaaaa caatcacaat aaacggcgtt 1158181 gaaatggaag cgtccgagga acagacggtg ctgcagcttt tgaataacag ctcgattgaa 1158241 gtgccgcaag tttgctatca tccaagctta gggccgattg agacatgtga tacgtgcatc 1158301 gtcagcatca atggtgagct gaagaggtcg tgctccgctg aattaaagga tggggatgtc 1158361 attgatacgc tctcacctga cgtgaaaaaa gcgcaggtca tcgggatgga caagatttta 1158421 tataatcatg agctttattg tacagtttgc gattacaaca atgggggatg cgaaatacat 1158481 aatacggtga aggaaatgaa aatcaatcac caaagcattc cgtttgatca caagccatac 1158541 cataaggatg aatcccatcc gttttatcgg tatgatccag atcaatgtat attgtgcgga 1158601 cgctgtgttg aggcatgcca agacgttcag gtaactgaaa cgctgaccat tgactgggag 1158661 cggaaacgcc cgcgcgtcat ttgggataac gacgtgccga tcaatgagtc gtcatgtgtg 1158721 tcatgcggcc attgttcaac ggtctgtccg tgcaacgcga tgatggaaaa aggaatggaa 1158781 ggggaagccg gatatttaac aggcatcaat aacgaaacgc tgcgaccgat gatcgagatc 1158841 acgaaaggcg tagagacagg ctacggctcg attctcgcga tttctgatat ggaatcggcc 1158901 atgcgtgatg aacgaatcaa aaaaacgaaa accgtctgca cgtattgcgg cgtcggctgc 1158961 agctttgatg tctggacaaa gggcagagac attctgaaag tagagccgca ggaggaagcg 1159021 cctgccaacg gcatttctac ttgtgtgaaa ggcaagttcg gctgggattt cgttaacagc 1159081 gaagaacgcc tgacaaagcc gctgatccgt gaaggcgatc atttccgtga agcagagtgg 1159141 gaggaggcgt tattgctgat cgccagcaag ttcactgaat taaaagaggc gtttggcccg 1159201 gattctctcg cttttattac atcttctaaa tgtacaaatg aagaatccta tcttatgcaa 1159261 aagctggcca gaggggtcat tggcacaaat aatgtggaca actgctctcg ctattgccaa 1159321 tctcctgcga ctgccggcct gttccggaca gtcggctatg gcggtgattc aggatcaatt 1159381 acagatatcg cgcaagcgga ccttgttttg attatcggtt cgaacacgtc tgagtcgcat 1159441 ccagtcttat ccactcggat taaacgggct cataagctga gagggcagaa agtgatcgtc 1159501 gcggatatca gaaagcacga aatggcagag cgctcagatt tatttgtcca gccgcgtgcc 1159561 ggatcggata tcgtctggct gaatgcgatc gccaaatatt taatagaaaa cggcaaggcc 1159621 gatgaacgat ttttgagaga aagagtgaac ggacgggatg aatatgtaaa aagcctcgcg 1159681 ccgtacacac ttgaatatgc tgaggagaaa accgggattg atcaagaaac ccttatccaa 1159741 atggcagaga tgatcgggca agctgacagt gtgtgcgcat tgtgggcgat gggcgtgaca 1159801 cagcatattg gaggaagcga cacgagcacg gcgatctcta atctgctgct tgtgacagga 1159861 aactacggaa aaccgggagc aggttcttac ccattgcgcg gccataacaa cgtgcaggga 1159921 gcaagtgact ttgggagtat gcctgacaga ctaccgggct atgaaaaagt gacggacgaa 1159981 caagtccgcc aaaaatacga gcgtgtgtgg ggtgtgccgc tgccgaagga gccgggtatg 1160041 accaaccacg aaatgattga aaaaatccat tccggacagt tgaaagcgat gtatgtaaaa 1160101 ggtgaagaaa tgggccttgt cgactccaat atcaatcatg tacacgctgc atatgaaaag 1160161 cttgatttct ttgtggtgca ggacattttc ctttcacgta cagcggagtt tgctgatgtg 1160221 gttcttcctg cgagcccgag ccttgaaaaa gaaggaacgt ttacaaacac agaacgccgg 1160281 attcagcgtt tgtatcaggt atttgaaccg ctgggtgaat caaagccgga ttggcagatt 1160341 attatggagg ttgccaataa gcttggcgcc ggctggctct atgagcatcc tgcagacatt 1160401 atggaggaag cagccaagct gtcgccgatt tatgccggtg tcacctatga acgtcttgag 1160461 ggctataatt ccctgcaatg gcctgtaaac gctgatggaa aggattcgcc tttactcttt 1160521 acagagcgct tccctttccc agacggcaag gccattctct accctgtcca gtggacagag 1160581 cctaaggaat tcggtgagga atatgatatc catgtcaaca atgggcggct cttggagcac 1160641 ttccacgaag ggaacctgac ttacaaatca aaagggattt cggagaaaac accggaagtg 1160701 ttcttagaaa tttctcctga gcttgcggca gaacgaggga ttcaggacgg aaccctcgtc 1160761 agactcacat cgcctttcgg aaatgtcaaa gtgaagtgcc tgattactga tcgagtcaaa 1160821 gggaaggaag tatatctgcc aatgaacgat tcaggggaag cggcgatcaa cctgttaaca 1160881 ggcagccatg ccgataagga taccgatacg cctgcttaca aagaaacatc ggccaagatg 1160941 gaaattttga agcacgacgg aatcagcccg ctgcctaaga tcaaccaccg caacggcaat 1161001 ccgcagccgc aaatcggtgt gcaggttcat aagaaatggg cgcggaagga ttatattttc 1161061 cctggtgacg ctgtgaaaag ggggatgggc cataatggct aaagcgatta aacgaatcca 1161121 aaaaatcgag gtaacagaag aggatcagcg aaagcgtgat ttgcgggaaa ttgaagatgc 1161181 tctaattgac cacaaagaag cgattctcga aacattgcat atgctgggcc atatgaacga 1161241 gcgcggggtc ctgccgttgc tccgcggcct ttttggtcaa ggggataaag ttcttgatat 1161301 cctggtgaaa aaggcagata cagaggaaac agccaatacg ctgaaaaatc tgcttcttct 1161361 gtttggaaca ctcggcatgc tggacgtgaa gcagctggag cctctcattt tgaaagtgaa 1161421 tgcgggtgtg gcaagcgctg tagagcagaa aaacagtgaa gaaaagacag gttattttga 1161481 tattatccgc tcgctaaaag acccggaaat caacaaatca attacactgc tcttttcctt 1161541 tttaaaagga atgggacaag atacaaagga gctggaacgc acgacgcagc ctccggaaca 1161601 ccaaaaacat catcaggaac cccgagagaa aagaggaatg aataagcgag attgacctcc 1161661 cacccgagcg gcttcagcca gctcgggttt tttgatgaaa aggtctaatg gactagtaaa 1161721 aaatattcaa atactaggaa gaagtaagat tgtgatgaat gagatagaaa taatcgttac 1161781 tttcttacct gttaagaaaa gggaaaatct gattataata gaaatcgatt actttagatg 1161841 ggggaacaat catgaaaaaa gtcttattac tattatttgt cttgacgatc gggttagcgc 1161901 tttctgcgtg cagccaatcg agcgatgcgt cagagaagga aaaaccgaaa gagaaaaaat 1161961 cgcaagaaga gcttgaaaag gaacttgata aggaattgaa aaaaggcggt gagccgaaga 1162021 ccaaaaaaga tgatcaaata cataaaatag gagaaacatt taaagcagga catacgaatt 1162081 ttacagtgaa taaagttgat agagtgcaaa aaggtgaata tatgaatgtt ggcggagctg 1162141 taaatgagga gacaaaaaca ataaaagatg atgaggaacg gcttattata gaagttacga 1162201 tggaaaatat aggggaagat tcaataagct acaattttat cgggtttgat ttaagagata 1162261 agaatgatca atcagtgcgg cctgtttttt ctatagaaga gaagggcaga atccttatgg 1162321 gaggaacact agtatcgggg aaaaaggtta caggtgtact cagttatgtc atccctaaag 1162381 gagaacagaa acattacaca ctggtatata atccgttttt agctgataca aatagcagta 1162441 atacagaaga gagagtaaag gacgatattg attacttggt gaagttagat tagatgctaa 1162501 tttacagttg cacgtttttc atctgtggaa aacgtgcatt ttttatagcg aaacttgact 1162561 tgaaaggatg agtgataaaa gtgcaaacca aatggctgga acgggcacag cggattcggg 1162621 cgatcgccca agcggggctt gctttttcca aggatgtgta cgacagggag aggtacgaag 1162681 agctaatgaa gcttagcgcg gaaatgatgg cggattactc ggagaaggac attgaagtta 1162741 tcactgattt atggcaaggc gagaagggct atccaacacc gaaagcggat gttcgcggcg 1162801 ctgtattcag agagaatcag attttgcttg tccgggagaa gcatgatgag ctgtggtcgc 1162861 tgccgggcgg attttgcgag attggtttat cgccggctga aaacgttgtc aaggaaatca 1162921 aagaagagtc ggggtacgat acagagccgt ctcgattgct ggccgtgcta gacagccata 1162981 aacactctca tccccctcag ccttatcact attataaaat cttcatcgca tgcagcatga 1163041 cggacgggca gggggaaaca gggatcgaga cgaatcatgc cgcttttttt ccggaagaca 1163101 gactcccgcc gctttctcct aaacgaaaca caccctcaca gcttagcatg ctgtttgact 1163161 ttttgcgcca tccggacaag aaaacgatat ttgactaaaa aagaaagagc ctgtgggctc 1163221 tttctttttt ataatgtaat gtgtttttcg ttggcgagtt tcagaagggt caaaatagaa 1163281 tcggcttgtt tatggccgag tttttgcttt aatttgtttt cttcaactaa tcggctgcca 1163341 taaattttga cggaggcttt gtcgacgaca gtatgccagt tttcctgttt ttttccctca 1163401 acaagcggtt tttcatgtct ctcagaaaaa gagaacacaa agagtacgaa tgcaagtgaa 1163461 agtaggattc cgacaacttg ttttttgtaa tcagtctgtg ctgccacgtt gttctctcct 1163521 tcacctttta ccttctattt aatcatagaa ccaaattatt ttacataatg ggaaagtcat 1163581 ttttggagtt agtgcatttg gttgaaaaca gagacgtttt ttgagcggag cggtgcaatt 1163641 gaatccatat tggatttgcg tgcttatgcc taaggtcacg ttgtgagcca aaacagcagt 1163701 gcagaataga aaaaaattga aagattatgg taagatgaac gaaattcgag ggggaatata 1163761 tgatgcctgc atcgaacatc gtgatcgcct gcctgctgtt atcaatttaa ttatttgtgg 1163821 tagtccctct ctttttcgaa agcgggaggt gaagtggaac attaattgct gaattctttc 1163881 aaggggagtg accgtacatg aatgtgttaa accgccggca agccttgcag cgagcgctgc 1163941 tcaatgggaa aaacaaacag gatgcgtatc atccgtttcc atggtatgaa tcgatgagaa 1164001 aggatgcgcc tgtttccttt gatgaagaaa accaagtgtg gagcgttttt ctttatgatg 1164061 atgtcaaaaa agttgttggg gataaagagt tgttttccag ttgcatgccg cagcagacaa 1164121 gctctattgg aaattccatc attaacatgg acccgccgaa gcatacaaaa atccgttcag 1164181 tcgtgaacaa agcctttact ccgcgcgtga tgaagcaatg ggaaccgaga attcaagaaa 1164241 tcacagatga actgattcaa aaatttcagg ggcgcagtga gtttgacctt gttcacgatt 1164301 tttcataccc gcttccggtt attgtgatat ctgagctgct gggagtgcct tcagcgcata 1164361 tggaacagtt taaagcatgg tctgatcttc tggtcagtac accgaaggat aaaagtgaag 1164421 aagctgaaaa agcctttttg gaagaacgag ataagtgtga ggaagaactg gccgcgtttt 1164481 ttgccggcat catagaagaa aagcgaaaca aaccggaaca ggatattatt tctattttag 1164541 tggaagcgga agaaacaggc gagaagctgt ccggtgaaga gctgattccg ttttgcacgc 1164601 tgctgctggt ggccggaaat gaaaccacta caaacctgat ttcaaatgcg atgtacagca 1164661 tattagaaac gccaggcgtt tacgaggaac tgcgcagcca tcctgaactg atgcctcagg 1164721 cagtggagga agccttgcgt ttcagagcgc cggccccggt tttgaggcgc attgccaagc 1164781 gggatacgga gatcgggggg cacctgatta aagaaggtga tatggttttg gcgtttgtgg 1164841 catcggcaaa tcgtgatgaa gcaaagtttg acagaccgca catgtttgat atccgccgcc 1164901 atcccaatcc gcatattgcg tttggccacg gcatccattt ttgccttggg gccccgcttg 1164961 cccgtcttga agcaaatatc gcgttaacgt ctttgatttc tgcttttcct catatggagt 1165021 gcgtcagtat cactccgatt gaaaacagtg tgatatacgg attaaagagc ttccgtgtga 1165081 aaatgtaata gataaggaga ctggagattc atgaaaaagt accatatttc gatgatcaat 1165141 atcccggcgt acggacatgt caatcctacg cttgctttag tagagaagct ttgtgagaaa 1165201 gggcaccgtg tcacgtacgc gacgactgag gagtttgcgc ccgctgttca gcaagccggt 1165261 ggagaagcat tgatctatca tacatccttg aatattgatc ctaagcaaat cagggagatg 1165321 atggaaaaga atgacgcgcc cctcagcctt ttgaaagaat cactcagcat tctgccgcag 1165381 cttgaggagt tatataagga tgatcagcct gatctgatca tctatgactt tgttgcgctg 1165441 gctggtaaat tgtttgctga aaagcttaat gttccggtca ttaagctctg ttcgtcatat 1165501 gcccaaaatg aatcctttca gttaggaaat gaagacatgc tgaaaaaaat aagagaagca 1165561 gaggctgaat ttaaagccta cttggagcaa gagaagttgc cggctgtttc atttgaacag 1165621 ttagctgtgc cggaagcatt aaatattgtc tttatgccga agtcttttca gattcagcat 1165681 gagacgttcg atgaccgttt ctgttttgtc ggcccctctc tcggagaacg gaaggaaaaa 1165741 gaaagcctgt tgattgacaa ggatgatcgc ccgcttatgc tgatttcttt gggtacggcg 1165801 tttaacgcat ggccggaatt ttacaagatg tgcatcaagg catttcggga ttcttcatgg 1165861 caagtgatca tgtcggttgg gaaaacgatt gatccagaaa gcttggagga tattcctgct 1165921 aactttacca ttcgccaaag tgtgccgcag cttgaggtgt tagagaaagc tgatttgttc 1165981 atctctcatg gcgggatgaa cagtacgatg gaagcgatga acgcaggtgt gccgcttgtc 1166041 gtcattccgc aaatgtatga gcaggagctc actgcaaatc gggttgatga attaggcctt 1166101 ggcgtttatt tgccgaaaga ggaagtgact gtttccagcc tgcaggaagc ggttcaggct 1166161 gtatccagtg atcaagagct gctcagccgc gtcaagaata tgcaaaagga tgtaaaagaa 1166221 gctggcggag cggagcgtgc ggcagctgag attgaagcgt ttatgaaaaa atccgctgtc 1166281 ccgcagtaaa aacataaaaa ccgaaatcaa tttgatttcg gttttctgtt taaatatttt 1166341 ttttcatccc gcatctccgg cattctctaa gaaattttcc gccttttaca gagcttttga 1166401 acagtgtgta atcacagttg tcgcagcgcc cgctgcgggc atccggatat tcattgaatt 1166461 cgtaaacaat cgatgtatcg tagccttttg tttcatattc ttcttttttg gtttccatgt 1166521 cgatcctccg ttacaagacg tgtctgctgt ttatcttaca gcaagcttcc ggcgtattca 1166581 atggatttta ggaggttggg tttatcttga tttctccctt ggtttgcgcc aaaatagctt 1166641 tattaagctt atatacataa aaagcctatg caaagaggag aggaaacggg tatgggaaaa 1166701 gggttacttg gaaaacgcgt ggcaatcggt ggctcacgaa aaacggaaga aattagtaca 1166761 atcattgaaa aacagggcgg aatacctgtc atccggcctc tccaaggtac agtttactta 1166821 gcagagaagc aggtggagcc ggatttgcgg acgtttgcgg aagaaaaagc tgactgggtc 1166881 attttcacga caggcatcgg gttggagact cttgtcgata tggcagagaa aattggactg 1166941 aaagatgagt ttctgcaggc cattcgccaa gcgaaagcgg catgccgggg atacaaaacg 1167001 ctgtctgcgc tgaaaaagct tggaatcaca ccggaagctt cggatgaaga cgggacaaca 1167061 agaggcttaa tccgttcctt ggagcctcac gacttttcag gaaaaacagt catggtgcag 1167121 cttcatggcg aaaaagcgcc ggctctcatg gcatttcttg aagaaaaagg cgcgtctgtc 1167181 ctgccgattc tgccttatca gcacatcccg ccggaggagg aaacggtgga gcggttatgc 1167241 cgagagctga tgaacgatga ggtcgatgcc gtttgtttta caacggccat tcaggttcgt 1167301 tccctgtttg attttgccaa ggggcgaggt tatatcaatg aagtgaagaa ggtattcgaa 1167361 gaacgcgcca tcgcagctgc tgtcggaaaa gtgactgctg aagcactgcg ggaagagggc 1167421 attacgagac tgcttgcgcc agagattgag cggatgggtg cgatgattgt tgagctggcc 1167481 aagtattatg aagaaaagga ataacaagta caaaaagccg cttttccctc ggaaagcggc 1167541 ttttgtctgt cattcatttt gcttcagctg ctgatgaacg gtgaataatg atgggtatgt 1167601 cagcacgctt aagattacac aagtcagcgc ggctgaggcc atcgttgtaa acacgattaa 1167661 gagttgaaag cgtactgcct gaatcgggtc cgcgccggct agaatctggc cagtcatcat 1167721 gccgggaagc tggacaagac ccagtgtttt ctggctttcg agcgtcggga tcatactcat 1167781 tttcatcgct gaggtaagaa tgcgctgtat ggattgcttc ggtgtgccgc caagtgacaa 1167841 tattaattga atttcttctt tgcgaacgcc gacttctgag ttaagccggt ttagaaacaa 1167901 acttgagagc accatcgaat ttccgatgac catcccgctg atcggaatga catatcgtgc 1167961 cgtaagcgga atgatatgaa gagacagcag aattccctgc gtcacaattt ctacgattgc 1168021 taacgcggca aacaccctcc aaaacgaacc gatagtattt ttctttcgct tgatgacatt 1168081 ttgcgccgcc accgcgagca ttaacagcac catcagcagg ataaaaacag ggtggtctcc 1168141 gcgaaaaatc agcgacaaaa cataaccgat gataagcagc tgcaccgcgg cccggatggt 1168201 ggcgatgatc atgtcttttt ctacaccggc tttaaaggat tttgataaaa acaaggcgat 1168261 caaaacaaag atcatcgtta aagagagaga aaggtaatcc attaccgagt gcctcccttc 1168321 aaaaattctt tcgctgcttc atgctgcgga gcggagaaaa atgtgtcggt ttcagcgatt 1168381 tcaagcagcc ggccatctgc cataaaccaa atggtatcgg ctattcgttt tgcctgctcc 1168441 atattatgag tgacccacat gactgtccat tttttctctt gatgctgacg tttgatcagt 1168501 tcttcaatct caagagcaga gaccgggtcc aaggccgatg tgatttcgtc caacaataga 1168561 atggaggaag gatttgagag cgttctggcc agtgacagtc tttgccgctg cccgcccgat 1168621 aagtctctgg cgcttctgtc taacaactct ggcggcagcc ctgcaagcga agccagcttt 1168681 tcaggagagt acagctggga ttgatgcagc ctttgtacaa gacttaaatt gtcacgcact 1168741 gtcccgtcga gcacgggagc cgattgaaac gcgagggctg ccgttcgcct cagctcattg 1168801 acattccatt ctctgacttc ctttccgtat atgttgactt cgccgctgtc aggcgttctc 1168861 attaaattac acatagaaag gagggtgctt ttgcctgagc cggaagggcc taaaacggct 1168921 acgattgcac cctgttgaat gtctccggtg acatcctgca gcacatcata ggtttgtcca 1168981 tcttgtttat agctttttct gactgatctg aaggagatgg ctggtatgtt ttgtgtttga 1169041 tcgtttgctt ccattacaat aatcaccttt caatataagt aggctgacat tatatttaac 1169101 tataacgtga aacagattcc ttttggtagc acaaataaag gagaacaggc tttcacccat 1169161 tctcctgcag atgctacgca gtcagatttg actgtgcttt ctttttcggt tttctcggct 1169221 gtgaagcgaa ggtatgtaac atcatccccg ctattataat gaacaaaccg gcaaatgata 1169281 atagagatgg gaaaacgcct gacagcagaa caatttcacc aagcagcgcg aaaatcactt 1169341 caccggattg agtggcttca acagctgcga gtttttgcgg attgtctctt accatatcag 1169401 tggcccagaa aaataaaacc gtcgcaatga tgcctgagct gacggcaacg ataaaggatt 1169461 gaacggtttg acttgctgtt ggaaggccat ctgaccacca gccgtaagct gctaatataa 1169521 gccagaatgg aaggcttgcc aatgtcattc caagcacgcg ctgaaatgta tcaagccggc 1169581 ctccgtattc ttcgagcatt cttcggtttc ctaacggata ggcaaaagcc gcaatgacaa 1169641 ccggcagcac actgaaaagc agcatcctcc cagaaagcga ttctgcatgc tgaagctgaa 1169701 tcagagccgc tccaatcagg atgatcacag aagtgccaag tgaaaccagg ggaatctttt 1169761 ggcgaatgag ctgcggaccg cccggcatat cttgtttgac ataaaacaaa ggagataaga 1169821 gcaccccggc tacaattgta atttgccagg ttccagctat gagccacccc ggaccgtatg 1169881 cagccgcaaa tgtaatcggt gcgtaaaaaa gcacgaaacc gacgaagctc catttgatcc 1169941 aataaaacgg ctttttcctc atttctagta agagaggcgt gaatgtccct ctcatgatga 1170001 caatcaaaca taaaaatggc accataaaaa taaagcgcag cgaagagctc caaagccagc 1170061 tgcctcctga taactccatc gctctgttta atataaaggt aacggcgaaa aagagtgaag 1170121 ccaatattcc gataacgata gctttcatga tatccctcat tctggcatta tttttttata 1170181 ctatactatt cggtatcatg cagatcaatg gaatcatgag aaaaacatca tgtttggcga 1170241 accgctatat gtggaagaca aaaaagggag gtgaaattga tggaaagaga gacacagaca 1170301 tacttctttc cggatgacgg caggattccg aatcaccctg attttccgct cgtggtgtat 1170361 caaaacgcgc ttaaggacac cggactggca gagcggatcg tcacccggca tggctggtca 1170421 aacagctggt cagggagtgt ttttccatac catcattatc acagcaatac gcatgaagtc 1170481 ctgattgccc ttaggagaga ggctgtgatt cagtttgggg gagaaaaagg ggctgccatc 1170541 cctttcaaat caggcgacgc agtcgtgatt ccagccggag tcggacataa aaagctcagc 1170601 tcaagccccg attttactgt ccttggcgcc tatcccggtg gcgttcagta cgatatgaag 1170661 acggggaagc cgaatgagcg ggaggaagcg gtcaaacaga ttaagcaggc ggcgttgccg 1170721 gcgaatgatc cgatcacagg aaaaagagag cctctattgg aaatatgggt aaagtgaagg 1170781 ggagaaattg ctggattgtc aataactagt gccgcagaaa cgatatgaca tgagctccat 1170841 ataaattaat ttcataatcg aagcaattca cgttcaaatt ttgttcaaaa agtgttatca 1170901 tatagaaggt aatcgaattg gagttttttg tgtttgctat tttcagagag agtaaaggat 1170961 tttgacttat tcaattgttt atttttagat aaaaataata ctgaatatgg caagatgaaa 1171021 aactgggtag taaacattta tttttgtaaa tgattgtgca tgaattcaca atccttattc 1171081 ttatgcctta aaagcgtgag acagggagag gcactaccct ttccaaaaaa atcagcaaac 1171141 tgcttatagt aaaggagaat tggatatgcc agaaacaatc gatcaaacaa atgcgtctgt 1171201 cagccaaagc cagcaagatc ttattgatca gctattaaag ccagaagttc aagaatcatt 1171261 gactgtttta gttgaccagc ttccgaagct gactgagtta gtgaatattt taacgaagtc 1171321 ttatgatttc gctcagtctg tagcgactga cgaagtgtta aagagcgaca cagtcggtgc 1171381 gatcactgaa attctcgagc ctgtaaaaga aacagcgaaa gaagtagctg cgactgcgat 1171441 cgaagcaaaa gaccgcgcgg aagcaagcaa cgaaacaatt ggacttttcg gccttcttcg 1171501 catgctgaaa gatcctcaag ctcaaaagct gttccgtttt gctaacagct accttgaagt 1171561 catgaacgaa cgcgaaaacc aaaaataatc tcagattcaa attgatataa aggacggagg 1171621 atatacgatg tcaaaacata ttgtcattct aggcgctggt tatggcggag ttctttctgc 1171681 tctaacagtt cgcaaacatt acacaaaaga acaagcacgc gtgacagtgg taaacaaata 1171741 cccaactcac caaatcatta cggaattaca ccgccttgct gcaggcaacg tgtctgaaaa 1171801 agcggttgca atgccattag aaaaactttt caaaggcaaa gacattgatc ttaaaattgc 1171861 ggaagtaagc tctttctctg ttgataaaaa agaagttgcg cttgctgacg gttctacatt 1171921 aacttacgat gcgcttgttg taggtcttgg ttctgtaacg gcttacttcg gcatcccagg 1171981 tcttgaagaa aacagcatgg tattgaaatc tgctgccgat gcgaacaaag tcttccaaca 1172041 tgttgaagat cgtgtgcgcg agtactctaa aacgaaaaac gaagcagatg caacaatcct 1172101 tatcggcgga ggcggcttaa caggtgttga gcttgttggt gagcttgctg acatcatgcc 1172161 gaaccttgcg aaaaaatacg gcgtagacca taaagaaatc aaattgaaac ttgttgaagc 1172221 aggtccgaag atccttcctg ttcttccgga tgatcttatc gagcgtgcga ctgcaagcct 1172281 tgaaaaacgc ggcgttgagt tcttaacagg tcttcctgtt acaaatgtag aaggaaacgt 1172341 aatcgatctg aaagacggat ctaaagttgt tgccaacaca tttgtttgga ctggcggcgt 1172401 acaaggtaac ccattagtcg gtgaatcagg cctagaagtg aaccgcggac gcgcgactgt 1172461 aaatgacttc ctgcaatcta catctcatga agatgtattc gttgctggag acagcgcagt 1172521 ttacttcggt ccagacggcc gtccataccc gccaactgca caaatcgcat ggcaaatggg 1172581 tgagctgatc ggttacaacc tattcgctta cctagaaggc aaaacgcttg aaacattcaa 1172641 gccagtaaac tctggtacac ttgcaagcct tggacgcaaa gacgcggttg ccatcattgg 1172701 tgctaattct acaccgctta aaggtcttcc tgcttccttg atgaaagaag caagtaatgt 1172761 acgatatttg acacatatta aaggactttt cagcctggct tactaatcct tttaatgaat 1172821 ctggcattgc caaaagcatt cctttccgag tgctttctgg caatgtcttt ttttatgttt 1172881 atgacagcgt taacatttca ttttcaaaaa agagattgat cccaaaggaa tataaaggta 1172941 aaataaaaac aaatcaaaat gttaacgtta acattttgaa atagaatgaa agacggtgag 1173001 gacatggaac ccttcatggg caaaaacttt ttattgaaaa atgaaaccgc tgtcagcctc 1173061 tatcacaatt atgcgaaaga catgccaatt attgattacc actgccactt aagtccgaaa 1173121 gaaatctatg aaaataagac atttcaaaac atcacggaag cctggctgta tggtgaccat 1173181 tataaatggc gcatcatgag agccaatgga attgaggaga catacattac cggagatgcg 1173241 cctgatgagg agaaatttat ggcttgggcg aaaaccgtgc cgatggcgat tggcaacccg 1173301 ctctacaact ggactcactt agaattgcag cgtttttttg gcatttacga gattttaaac 1173361 gagaagtccg ggtcggctat atggaaacag acaaataaac tgctcaaagg ggaaggcttc 1173421 ggggcaaggg atttaatcgt gaaatcaaat gtaaaggtcg tgtgcaccac agatgaccct 1173481 gttgattctc ttgaatacca tttattgtta aaagaagaca aagactttcc tgtcagtgtg 1173541 ctgcctggat ttcggccgga taaaggactt gagatcaatc gtgaaggctt tcctgagtgg 1173601 gtgcaggcgc ttgaagatgc cgctgccata tcgattacaa cctatgatga gtttttaaag 1173661 gcgttggaaa aacgagtgcg attcttccac tcagccggcg gcagagtttc tgatcacgcg 1173721 atagatacaa tggtatttgc cgaaacaaca aaagaagaag ctggacggat tttttctgac 1173781 agattacaag gaacagaggt ttcttgtgaa gatgagaaga aatttaagac atatacgctt 1173841 cagtttcttt gcggtttgta tgcggagctc gattgggcga tgcagtttca tatcaacgct 1173901 ttaagaaaca cgaatacaaa aatgatgaaa aggctcggac ctgatacagg gtatgattca 1173961 atgaacgatg aagaaattgc taagccttta tacaagctgc tgaactcagt tgagatgaag 1174021 aaccagctgc cgaaaacgat tttatattca ctgaatccaa atgataacta tgtcatcgcc 1174081 agcatgatca acagttttca ggacggtatt accccgggaa aaatacaatt cggcacagcc 1174141 tggtggttta acgatactaa agacggaatg ctcgaccaaa tgaaagcgtt atcaaatgtt 1174201 ggccttttca gccgttttat cggcatgctc accgattcca gaagctttct ttcgtatacg 1174261 cgccacgaat atttcaggcg gatcgtctgc aatttgattg gagaatgggt ggaaaacggc 1174321 gaagtgccgc gcgatatgga gcttctggga agcatcgttc aggggatttg ctatgacaat 1174381 gcgaaacact actttcaatt tcaagaagag aaagcaaacg tgtaacaaag tgtccgctca 1174441 gtatcgctga gcggatcact atccgaaaat tcttaagaca cagaggtgga acatgcgaac 1174501 tgaactggca aataaggttg tgtcggtcga aacggaaaaa aggctttcat tgaaagagaa 1174561 aatgtcctat ggctttggtg attttggcaa cggttttatg tttgatctcg gccagattta 1174621 tttattgaag tatttcactg atgtagcggg aatccccgct gcgatggccg gcggcatttt 1174681 tttagtcagt aagctgtttg cagcgataac agatccaatt gtcggctcat caatcgatta 1174741 tcgcaaaaac atcggcaaac gggggaaatt caggccttat ctattaatcg gcagcatcgt 1174801 gcttgcggtg cttactgttc ttatttttct gtctcccaat gtatcaacga ccggaaaact 1174861 gatatatgca tatgcatcct atatgatttg gggcatcggc tattcgtttg tgaatattcc 1174921 gtacggctca ttaggggcag cgatgactca aaattctgag gaccggacct ccatttcgac 1174981 gttccgccaa atcggatcac ttggcgcctt gtttatcaca agtgtggccg tgatgccgct 1175041 gctcgtcaag tttgataatc cgaaggtcgg ctacccggtg gtcatgggct tgttcgccgc 1175101 gctcggtgtg ttttggtttt atatttgcta ccgcaactgc aaagagcgca ttatcatatc 1175161 ggaagcaccc aaagaaaaat taacactctc atctgtcgtc aaaacattta ttacaaataa 1175221 accgctgtta acccttgtcc tgatgacgat tttttcaatt tccgcataca acattaaatc 1175281 cgccatgctc gtctatttcg cacaatataa cttgggcaat gttgaattaa tggcttatat 1175341 gaacttcatc attattggtt cttccttttt gggcgtcgta ttccttccaa agctcgtcaa 1175401 gatgtttgga aagaaacgaa cggcaatgat cggctttggc atcagtgtgg ccgcggatct 1175461 gatcaacttt atgcttccat ctaacgttta tgtgtttaca attctcgcca gtatcgcctt 1175521 tatcggaatc agtatcccaa atggcatcac gtgggctctt gtctccgata ttatcgacta 1175581 tggcgaatgg aaatccggtg aacggaagga agcaacgaca tattcacttt tcaatttctc 1175641 aagaaagctt gctcaatctt tgtctggctt tctctcgggg atcggtttgg ggattatcgg 1175701 ctatgtgccg aatgcagtcc agacagcaca ggcgctgatt ggcatcaaag cgctgcttct 1175761 tctgtatccg gccattgctt tggcattagc gatgttcatt atcggctttc tttataaact 1175821 cacagaccag cagcatgctc agatcgttca ggatcttcat caaaagagct gacaatataa 1175881 tataaagaat atttaaaata atttgtaaat aaaatgtgtt tgtaggggtt tcgcttggag 1175941 agtgcccaaa aaactgaaaa ggaaggaggc acttgcttga aaacgataac aattgcagct 1176001 gaagaagcaa aggaactcgt ttggcaaaag ctggacggtg ccggtttgaa tgaacgagat 1176061 gctgaaaaag tggcagatgt tctcgtgcac gctgatttgc gcaatgtaca ttcgcatggc 1176121 gtgctgcaca cagaacacta tgtgaacagg cttttagcgg gagggatcaa tcctggggca 1176181 cagcctgttt ttaaagagac ggggcctgtg accggggtgc ttgacggaga cgatggtttc 1176241 ggtcatgtga attgcgacat ggcgatggac catgcaattg acatggcgaa gaaaaaagga 1176301 gtcggcatgg tcacggccgt aaacagcagc cattgcggag cgctaagcta ttttgtgcaa 1176361 aaagcggctg acgaaaagct gatcggaatg gcaatgacgc atacagacag tatcgttgtc 1176421 ccatttgggg ggaggactcc tattttaggg acaaatccga ttgcttacgg agttccggct 1176481 aagcataaaa aaccgtttat cctagatatg gcgacatcca aagtggcttt tgggaagatt 1176541 ctgcaggccc gtgaagaggg caaagaaatt cctgaaggat ggggagtcga tgaaaacgga 1176601 gaagcagtaa ctgatcctga caaggtcgtc tcactttcaa cattcggggg cccgaaaggc 1176661 tatggactat cgattgtagt ggatgtgttt tccggattgc tggcgggcgc ggcttttggc 1176721 cctcatattg ccaaaatgta caacggcctt gatcaaaaaa gaaagctggg gcattacgtt 1176781 tgcgcgatca atccatcctt ttttactgac tgggatacgt ttttagagca gatggatgcc 1176841 atgattgatg aactgcagca atcaccgccg gctgttggat tcgaaagagt gtatgtgccc 1176901 ggcgagatcg agcagctgca tgaagaaaga aataagaaaa acggaatttc tatcgcccgg 1176961 agcgtgtatg aattcttaaa aagcaggtga gtaaaatgaa agcggttcaa gtgcgaaaag 1177021 cgtatgatct ggtgacagcg gaggtgaaga agccagttct ttcaaaggat gatgaagtgc 1177081 tcgtgaaagt caagcgagtc ggcatttgcg gttcagacat gcacatttat catggaacga 1177141 atccgctcgc taccctcccg agagtcatcg gacacgaggt aacgggacaa gtggaggcag 1177201 ttggtgcgaa tgtacagagc ctaaaacccg gtgatcatgt ggtgattgag ccgatttctt 1177261 attgcggatc gtgctatgcc tgccgcaaag ggcggccgaa tgtttgcgcc aagctttctg 1177321 tatttggcgt acatgaggac ggaggcatgc gggaatatat tgtgcttccg gaaagacagc 1177381 ttcacgcggt ctcaaaggac ttgccttggg aggaagcagt catggccgag ccttatacga 1177441 taggcgccca ggcagtgtgg agaggccagg tggaaaaagg tgataccgtc ctgatccagg 1177501 gagcggggcc catcgggatc tgtgtgttaa aaatggcaaa actggcgggc gctgctgtca 1177561 tgatgactga cttgaacaac gagcggctgg catttgcgaa agaaaacggc gccgatgctg 1177621 ttgtaaatgt ccaagcagaa catgttgccg agcgggtcct tgaatggact gggaatgaag 1177681 gagcaaacgt ggtcattgat gctgtttgcc tgccggagac ttttgcactt tcaattgagg 1177741 ctgtgtcacc ggcgggacat gtggttgtgc ttggatttga tgaaagagcg gctcagattt 1177801 ctcagctgcc aattacaaaa aaagaagtca cgataaccgg atcccgattg cagaccaatc 1177861 agtttccaaa agtggtagag cttttgaatg gaggccggtt aatgcataac gggctggtga 1177921 cccatacatt ttcagttgat gacgttcatc atgcatttca gtttattaag gagcatccag 1177981 atcaggtgcg gaaagccgtc atcacgtttg attaaatgac tgaatccgga ggtgcgagca 1178041 tgaatatgac attccgatgg tatggacgag gcaacgatac agtcacactt gaatacgtga 1178101 agcaaattcc cggtgtcaaa ggcatcgttt gggctctcca tcaaaagccc gtcggcgacg 1178161 tgtgggaaaa agaagaaatc agagccgaaa ctgaatatat tcaatcctat ggttttcatg 1178221 ctgaagttgt agaaagcgtg aatgttcacg aagcgattaa acttgggaac gaagaacgcg 1178281 gccggtatat tgaaaactac aagcaaacga tccgcaacct tgccggattt ggcgtgaaag 1178341 tgatctgcta taattttatg ccggtttttg attggacacg cacggacatg ttccggccgc 1178401 tagaagatgg atcgaccgct ctgttttttg aaaaggccaa ggtggaaagc cttgatcctc 1178461 aagagctgat tcggacggtg gaggaagcat ccgacatgac actgccgggg tgggagcccg 1178521 aaaaattggc tcggatcaaa gagctttttg ctgcctacag aacggtcgat gaagaaaagc 1178581 tatgggacaa tttatcattc tttttgcagg aaattcttcc tgttgctgag gcctatggtg 1178641 ttcaaatggc cattcatccg gatgacccgc cgtggccgat tttcggactg ccgcgcatta 1178701 tcacaggaga ggcaagctat aagaaactgc gggcgatatc agattcaccg tctaattgta 1178761 tcaccctttg tacaggttca atgggagcca atcccgctaa cgacatggtg gagatcgcta 1178821 aaacgtatgc cggcatcgct ccattttcac atattcgcaa tgtgaaaatt tatgagaatg 1178881 gcgattttat tgaaacatct catttaacaa aggatggttc gatcaacatt caaggcgtga 1178941 tggaagaact gcataagcag gattacgaag gatatgtcag accggatcat gggcgccatc 1179001 tttggggcga gcaatgccgc ccgggatatg gcttatacga tcgggcactt ggcatcatgt 1179061 atttgaacgg gctgtgggac gcttatgaag caatggcaaa aaaagaggtg ggcatatgat 1179121 cccgctgcat gagaacctgg ctggtaaaac ggctgtcatc actggcggca gcggcgtgct 1179181 ttgctctgcg atggcccggg agctagcccg tcatggcatg aaggtggcga ttttgaatcg 1179241 gacggctgaa aaaggccaag cggtcgtgaa ggagataacg gcggctggcg gcacagcgtg 1179301 cgctgttgct gcggatgtgc tggacaggat gtcactggag cgggcaaagg aagacatcct 1179361 tggccaattt ggcgctgttg atctgttaat taacggggct ggcggcaatc atcctgacgc 1179421 gataaccgat gtggagacat atgaagaagc gggagaaggc caatcctttt ttgatatgga 1179481 tgagaggggc tttctaactg tattctccac caacttcacc ggtgcgtttc tggcctcgca 1179541 agtgtttggt aaagaactgc tgaaggcgga ttcacccgcg atcatcaacc tttcttccat 1179601 gagtgcttat tcacctatga cgaaggttcc ggcatacagt gctgcgaaag catccatcaa 1179661 taattttacg atgtggatgg ctgttcattt tgccgaaacc gggctgcggg tcaatgcgat 1179721 tgccccaggc ttctttctga caaaacaaaa tcatgatctg ctgatcaacc aagacggaac 1179781 gttcaccagc cgatctcaca aaattattgc gggaacaccg atgaagcgct tcggaaaacc 1179841 ggaggatttg ctcggtacgc tcctttggct ggcggatgaa tcctattccg gttttgtcac 1179901 tgggatcacc gttcctgtcg atggaggatt tatggcttat tcaggtgtgt aacgaaagcg 1179961 gtgcaacaga aactgaacca acataggggt gaggttgaga tgttttcaaa agataagctt 1180021 cccgttatcc tttttttgtt cctggcaggg gtgattaatt acctggatcg ctcggcgctt 1180081 tccattgcag ctccttttat tcaggatgat ctcacattgt ctgccacaca aatgggcttg 1180141 attttcagca gtttttcgat aggttatgcc atttttaatt ttcttggggg cgtggcatcc 1180201 gaccgctatg gggcaaagct gaccttgttt gtcgcgatgg ttgtttggtc gctgtttagc 1180261 ggagcagtcg ccctcgcttt tggctttgtc agcctgctga ttatacgcat tctcttcgga 1180321 atgggagaag gcccgctttc ggcgaccatc aacaagatgg tgaacaactg gttcccgccg 1180381 acccagcggg cgtccgttat cggtgtaacc aacagcggca cgcccctcgg gggagccatt 1180441 tccggcccga tagtcggcat gatcgcagtg gcgttcagct ggaaggtatc cttcgttctc 1180501 attatgatta ttggattgat atgggcagtg ctctggttca agtttgtcaa agaaaagccg 1180561 caagagacga tcaaggaagc accggcaata aaagcagaaa cgtctcccgg agaaaaaatt 1180621 ccgctcacct tttacctgaa gcaaaaaaca gtcctgttca cggcgttcgc ttttttcgct 1180681 tacaactaca tcctcttctt ctttttgaca tggtttccga gctatcttgt cgacgagcgg 1180741 ggattaagtg ttgaatcgat gagtgtcatc acggtcatac cgtggatttt aggatttatc 1180801 gggctggctg cggggggatt tgtttctgac tatgtgtaca aaaaaacggc ccgaaaaggt 1180861 gtgctgttct cgcgcaaggt tgtgcttgtc acgtgtttgt tttcatcagc tgtcctgatt 1180921 ggttttgccg ggcttgtggc aacgactgcg ggggctgtca ctcttgtcgc tctgtcagtg 1180981 ttctttcttt atttgaccgg tgctatctat tgggctgtca ttcaagatgt ggttgatcaa 1181041 aacaatgtcg gttctgttgg cggcttcatg catttcctcg ccaacacggc aggaattatc 1181101 ggcccggctt taaccggatt tattgttgac caaacaggca cgttttctgg agcatttttg 1181161 cttgccggtg ggctggctgt cttcgcttca cttgctgtga ttcgttttgt ccgtccaatc 1181221 attggtaagc cagcgggaac agaagctgag aatcctgtgt cttattaatc tggaaatata 1181281 gtgggagagg cggtatgttt gatgatacaa tatacagtaa ataatcgcag ccggtatgat 1181341 aaggaaggga attagatggt aaccataaaa gatatcgcaa aactcgcaaa cgtatcccac 1181401 actactgttt ccagagcact caacaacagc ccttacatca aagaacatac gaagaaaaaa 1181461 atattagagc tagcagagca gctcaactat acaccaaatg taaatgcgaa aagtctggcg 1181521 atgcaaaagt cgcatacgat cgggctattc tttacaagca ttacaaacgg aacctcacac 1181581 agcttctttg cagacactat caaaggcgtc aatcaagcca taagtgagga ttacaatctg 1181641 tatgtgcgcg gcattgatga tctgaaaaac tatgactccg ttacaccgat gagatatgac 1181701 ggcatcattt taatgagcca aagtgacatt gataattctt ttatttacca tattcgcgaa 1181761 aaaaacattc cgcttgtcgt gctgaatcgt gatattgatg atcgtaccat cacgaatatt 1181821 ttgtccaatg acaaggaagg ctctcaagaa gctgtagaat acttcattca gtccggacat 1181881 caagacatcg ccatcatcga ggggatcgaa ggctttaaat cctcccagca gcgaaaggaa 1181941 gggtacttat ccgcactgat tcaacatcat attccgatca agcatgaata cagtgtcaaa 1182001 ggacagtacg atatggaaag cggctttcaa gcgatggagc ggctgctggc actgccgaat 1182061 cctccaaccg ctgttttttg ttcgaatgat gacatggcaa tcggagcgat gaatgcgata 1182121 ttcgcaaagg gcctgcgcgt tcctgatgat atttcggtga tcgggtttga tgatattggg 1182181 ttttcacagt acatcacgcc aaggctttca acagtaaagc gcccagtgga gaaaataagc 1182241 gtgctcggtg cgcaaaaact cttgtcgctg atcagcgagc ccgaaacaaa agcagaaaaa 1182301 atcttggaaa acacagaatt tatggtgcgt gattcagtca gacgattgac gacgtgatgt 1182361 cccgtttttc agcgggcatt ctttatacag aaaaatgtta acgtgtgcat aaagtgagag 1182421 ggaggcaata agggtgcaga agctgaataa aaatgtgtac gatcactata ctcagtatcc 1182481 agaaaaaatt ctccaattcg gagaaggaaa ctttcttcgg ggatttatcg attggcagat 1182541 tgatcaattg aatcaacaca ctgattttaa tgggagcgtg gcagttgtcc agccaagagg 1182601 ctcagaaaaa atcaaacgat taaatgagca agatggatta tatacacttt ttttacaagg 1182661 aatgaaagac ggagaagcgg taaacgagca tatgattatc aactcaatca gccggggaat 1182721 tgacctgttt tctgattatg aagcatacaa agaattggca tcaagcgaaa ggcttcggtt 1182781 tattatctcc aacaccactg aggctgggat tgtatgtgat gaaaaagatc gtttagagga 1182841 taggccgcaa aaaacattcc ctgggaaatt aactgcattt ctttactttc gctatcaggc 1182901 ttttaaagga gatcagacaa aagggtgtgt cctgatccca tgtgaactga tcgagaataa 1182961 cggtgaaaag ctgagggaaa cggttcttca ttatgcacat ctgtggaagc tggaggaagg 1183021 atttacacag tggattcatg aggccaatac attttgtaat agtttagtag accggattgt 1183081 tccgggtttt cccgtcgaca gcattgatga gatcacggca gatcttggct atcaggatga 1183141 tttgatagtt gtgggagagc aatattattt gtgggttatc gaggggcctg attggattgg 1183201 aaaagaactt ccctttgcgg ctgcagggct gcatacaaag atcgtcagcg acctcacccc 1183261 ataccggact aaaaaagtaa gaattttaaa tggcgctcat acagcaatga cgccagtggc 1183321 tttattatac ggcttgaaga ctgttaggga tgcagtcgag catccggaag tggggcgatt 1183381 tataagagag ctgattgatg acgaaattct tcctgtttta aaaatggaag gtctttctca 1183441 gtatgctgac gatgtgctga accgttttaa aaacccgtat attaagcatt acctggaaag 1183501 cattgcattg aacgccattt ccaaattcaa aacgagaaac ctgccgactc ttaaggaata 1183561 tgctgaacaa aagggacagc ttcctgaacg cttggtgttt tctttcagcg ctcttctgta 1183621 tttttatcat gataacgaga cattgcagga tgatccggca gttcttcaat ttttcaaaga 1183681 ggtttggtgt caggaggatg gcgacatgct tcggattgca tcaagagtgt taggcgaaca 1183741 gcggctgtgg ggggcagatc tcaatgagat accgaagctg actgatagag tcgctgttta 1183801 cttgaatcat attcatgagc tgggcatgca gagggctctt gaacaatact gcatacaagg 1183861 gggagaggta cgttgaagtc gtttataaag attcataagc aagataatgt ccttcttgct 1183921 ctgcgggata ttcaaaaggg agagaggctg catgcttacg gcgtgtcgat tgaagtaaag 1183981 gatgatataa aaagaggcca taagattgca ttgcagtcta tcaaagaaaa cgacagcatc 1184041 gtcaagtacg ggtttccaat cggtcatgca tcacaagata tctcgatcgg agagcatatt 1184101 catgtccata atacgaaaac aaacctgtct gatatccaat tatacagcta tacaccgaga 1184161 tttgatgaaa atccgtattc taatgagaac cggacgttta aaggttttag aagagaaaac 1184221 ggagatgcgg gtgtacggaa tgaattgtgg attgtcccaa ctgtcggctg tgtcaatgga 1184281 atagcagaaa aaatgctgca gcgttttgtc agagaaacag gggatatcgc tccatttgat 1184341 aacgtactgg tgttaaagca tcaatacgga tgctcgcagc ttggcgacga tcatgaaaat 1184401 acgaagcaga tcctgctgaa tgccattcgc catccaaatg ccggcggcgt cttggtgtta 1184461 gggcttggct gtgaaaacaa tgagctggca agaatgaagg aagcactgca agatgtgaac 1184521 ttgaagcggg tgaagtttct ggaatcccag tcggtgaccg acgaaatgga ggcaggcgtt 1184581 gctttgctga aggaaattca tgaagcggcc aaaggagata agagagaaga cattccgctg 1184641 tctgaactga agatcgggct gaaatgcgga ggttcggacg gtttttccgg cataaccgca 1184701 aacccgctgc ttggacgttt ttcagattat ctcattgcac agggagggag tactgtgctg 1184761 acggaagtac cggaaatgtt cggcgcagaa accatcctga tgcagcgggc tgccaatgaa 1184821 gaagtgtttc ataagatagt cgatttaatc aatgatttca aacaatactt tattaaacat 1184881 gatcagccgg tgtacgaaaa tccttcaccg ggcaacaaag cgggcggcat ttctacactt 1184941 gaggataaat cgctgggctg tacgcaaaaa gcggggattt ctcctgtcac ggatgtcttg 1185001 aaatacggtg aagtactcaa gacaaaaggg ctgactcttt tgagcgcacc gggcaatgat 1185061 ttgatcgcct cctccgcatt ggcggctgcc ggctgccaaa ttgtcctctt tacaacggga 1185121 agaggcacgc cgtttggcac ctttgtcccg acggtgaaag tagcgacaaa caccgagctg 1185181 tatgaggcga agccgcattg gattgatttt aacgcaggcc ttttagcaga ggatgatgtt 1185241 catgaggaat atgtgctgcg tgagtttatc cactatatga ttgaggtggc aagcggccag 1185301 cttgtgaacc atgaaaaaaa tgatttcaaa gaactcgcca tttttaaatc gggtgtgacg 1185361 ttataataag aaaaggctat ccttcaagcg gatagccttc ttcattaaat caattttaaa 1185421 ccgctgacta aaataatgga agccataata aattgcagtg gacgcgggga gaatcgaggc 1185481 gaaagatggc tcccgatcag tacgccggga attgaaccga ggagcagatt agctgccagc 1185541 atgtaatcca cgcttccgaa gcttgcgttc aaaatgcctg ctgccgtaac aagaagaaaa 1185601 gcatgcgcga tatcggttcc gacaatctgt gacgctttca tgttaaataa gtaaatcatg 1185661 gcgattgcaa ataatgagcc ggacccgatt gatgttaatc cgacgataaa cccaaacaca 1185721 acaccaataa gaattgtcag cgccctctta ttttcaagcg gcatcagctg ccagcggttg 1185781 gggcgaagtt ttctatccaa aaacaaacga acgatgattg aaatggcaac cagcgttaac 1185841 acatatccta gagcgtgctt aataatttct tcctgatgct ggtgaaaggc ggggaacaaa 1185901 tgcaatatgc caatggctag cgaagcactc ggaataccgc cgatggctaa gtattttacc 1185961 aatttaaagt taatcgtttt ctgccgccaa tgggaggcaa cgccaaacag ctttgtgatc 1186021 gagttatata caagatccgt accgaccgcg atggaaggat taattccaag cacaattaaa 1186081 aggggagtta ataaggccgc tccacccact cccgtcaatc cgactaaggc tccgacaaac 1186141 aaacccatca atatgatgct tacactcatg ataaaggcct cctgaaaacc cgactagaat 1186201 tcacccgaat cttattcgcg ttggtcaagt attaattgta agtgctccat cggctgctga 1186261 aaaacccgag ctctatccgc tccctgatgg tatcattcaa ttgacaacac cttatacatc 1186321 aggagaacac gtctttcagg tgcaacgagc acttgcggct ctgtattttt accctgataa 1186381 aggcgctgtt aacaacggaa ttgacggcgt ttacggaccg aaaacagctg acgcagttgc 1186441 ccgttttcag tctgttaacg gtctaactgc tgacggtatc tacgggcctg cgacgaaaga 1186501 gaagatcgca gcgcaattaa gctgatcaaa gaccataaaa atcccggagc cgctccggga 1186561 tttatttttt cttcttcaac ttttttataa ttccagcact gcgctccctc acccgaagcg 1186621 agtacccgga aagcccaaac cttccgtaat caacaaactt cacacgcctc accaattttt 1186681 tcactgtatc acctgacatt atcctctgtt tgtatttatt atatgtcacc ctttaagaaa 1186741 aggaataagg acaagagctg ttttcccttg tccttttagt gtgatcatgc tttttttcgt 1186801 ttatactcgt caatcagccg ttcgttttct ttgaagattc ttgctgtatg cggactgact 1186861 tgatagcttg cgacactggt ggttgaacgt tttttcagga ttttaaacgg cttcgccgct 1186921 ctgggctcgc atctgttttg aaacgcacgt tccattatcc ttcaccttcc tcctcaattg 1186981 gcagcaccaa atcatatatg ctcgttaatg acgtaaatag caaataatca aattccgtga 1187041 caatgctgtc agacgtcagc ttgatgacat agttctgtgt ctcgatggta aaagggatga 1187101 gaaccacttt tccgtattgg tcgtaataaa catcctttcg atcgagccgt gtttgtacat 1187161 ctgccggatc atccatatgc tcggttaacc ggtctttatc agcctgtgtc gaatagtggc 1187221 aaagagaagc cgttaagttc attttatcag cataggtttt cagcagctta tcaatacctt 1187281 cagcataagc atctatactt ccataataaa catggatcgg ttcgtttttc aataggtatt 1187341 ggtatgtttt cagccgattg agatacatgt ggagcatttc gttgttttct tcaagaattt 1187401 ctcttgtgtc tgtttcaagc tcgctgccgg ccagtttttt gacatatgca cttaagaaga 1187461 taaaagcatc aatcaaagca aaactgactg cgacaatgag ataccgttcc cagtgggtaa 1187521 atagggaagt gggctcatat gtccagtata ccatagcgcc cagaacaaac agcaaatacc 1187581 aagttttccg aatggcggac attttttctt tgaccttcgc ttcgaaacgc cacgtggcat 1187641 acacgtataa ccccagtccg gccacgatgc accagaccat gatctgaaag aataaaacca 1187701 tattcgaatc cctcacatct gaaataggtt ctgcttattg tattcgagag atccggatgg 1187761 ttttcctgtt ccatcaaaaa aaccgctcct ttgacagaag cggtgtgaca ttaaaatatc 1187821 atatttaaaa taaagtaggc gatggcacca agtgtcgctg aaatcggaag cgtgatgacc 1187881 catgtaatga gcattcgctt ggccgtaccc cagtttacgc cttttacgcg gtgggacgca 1187941 ccgacgccaa gaattgatga agaaatgacg tgggttgtac tgaccggcaa atgaataaac 1188001 gtggcgccga aaataatggc tgctccggtt aagtcagcgg aaacaccgtt taccggacgg 1188061 attttcatga tctttccgcc aacggttttg atgattttcc agccgccgat tgatgttccg 1188121 agacccatgg ctgtcgcgca ggcgaattgc acccaggtag gaatatcatt agcagaagta 1188181 tgtaaattcg ctgtgatgag agccattgtg ataattccca ttgctttttg cgcatcgttt 1188241 gttccgtgtg tatacgattg cagggcagct gttacaatct gcactctgcg gaattgctta 1188301 ttcgttttcg ccaagttgct gtctttgaaa atcagcttaa cgatgctata aagaataaaa 1188361 ccaaggacaa aggcaataat tggtgataga atcagtgctt caatgatttt aatgaagccc 1188421 ttatagttta acgctgcaaa tccggctgcc gcaatggctg caccggcaat agcgccgatg 1188481 atggcatggg atgagctgct tgggataccg tagtaccatg tgataaggtt ccaggcaatt 1188541 gcagcgagta gcgcagccaa aatgacaaca gagccatttt ccagcgtata aggatctacg 1188601 atgtctttcg taatggtttt ggcaacacct gtaaacgtca ttgctccgac aaagttcatc 1188661 acagcagcca atataatggc atggcgcggt tttaacgctt ttgttgatac cgaagtcgca 1188721 attgcgtttg ccgtatcatg aaacccgttg atgaaatcaa acgccagagc acaaatgact 1188781 attagtatcg ttaatattaa tagaatatcc atttttaccc ctcgttacgc gtttttcata 1188841 atgatggttt caagattatt ggcaacactt tgacaagagt cggcgatttc ttcaagcgtt 1188901 tcgtatattt cacgatattg aatgactttg attggatctg tttcatttcc gaaaagattc 1188961 tttaatgatt ttctgtgcaa gttgtcacaa ctgtgctcat actctttaat tttgattgcg 1189021 tgaggctgaa tatcctttaa gcgattttct gccagcagct cgatcgtaat caaaatctct 1189081 ttcgcacatt ctctgatata tccgctgaat ttatcaatat gctcgtctga tgaagtaatt 1189141 gagaaaatct ccatcatggc agagaaatgt tcgattccgt caagcacatc atccaagctg 1189201 tttgtcagct gaaggatatc ttcgcgctca ataggagtga tgaacgcttt gttaagctct 1189261 ttaatcatga catgaacatg attgtcacct tttgtttcat attcctttaa cgtatctgca 1189321 aattctttaa gagtcgtttg gttagtgacc ttaaaattca caaaatattc tgcagtttcg 1189381 tctatgttct ttgcaatttc tgttaaaagg agtgagaact tatctttttt tcttcttatc 1189441 attaaaaacc ctccatagtt tgaatgaaca atgcacacat caaattatta tatagccttt 1189501 tgtcgaaaaa aaacaggtaa agtcgaaaaa aacgtatctt gacttttttg ataaatcgtg 1189561 tctccttatt ttgacctact tcgctttaaa aaaacgaccc aagtttgcaa aaactttctg 1189621 cttaacgtaa aaagtatatc aaaagttgtg tttttcctgt caacttttat cttctgtttc 1189681 accaaaaaac ggttccctaa acaagggaac cgttttatca gcttgctttt cgttttttca 1189741 tcccgtaata aacaggcagt ccggcaaggc cgatgaggat ggataatccg cagctcattg 1189801 tatctgtaat gagtgtgctg cctaacacaa agaaggagcc cgcgattgcc agaattggca 1189861 taaatggata aagcggaaca ctgtaggcgc gcttttctcc ctttgctcgc ttgcggagaa 1189921 taaacactgc aaaaaaggcc atcacataaa aaatgtagat catgaaaatg gagatttctg 1189981 agagcttatc agggttgctg atcagcatca taatcaaagc caaagcaatt tgaaaagaaa 1190041 tcgcaatcca tggtgtgcgg aacgacgggt gtacatgtga cagtttttca gcaaatggaa 1190101 gctgtttgcg ttccgccatt gcaaatgaaa cacgcgggaa agaaagcacc tttccattta 1190161 agcacccaaa gatgctgacg ataatcccta cactgatcag ctttccgcca attgaaccga 1190221 acagcatggt tgcagcggtg cttgtcgcat tttcaccaag cgtgacaatt tcgttcgctg 1190281 acaggatgtg aagcaatgca aaattaatga aaatatagat cgccgttaca attaataatc 1190341 cgcccgtcat agcgcgtggc agcagctttt cgggattttt catttctccg ccgagagcgg 1190401 caaggagaat ccatccgtca taagcaaaca acgtagctaa aatagccgcc ccgaagttca 1190461 tatcagaaat gctttcgttt actgctgtga agatgtgctg atcgcctttc caaaggccaa 1190521 agacgatgat gcaggcaatc ggaatcagtt ttccgatcgt tgtcagcgtt tggacaaaac 1190581 cgccgtattt tgtaccgata atattaatga cgcataaaaa gagaactgct ataattccaa 1190641 tgacttttga tagtccagat ccccagccga aaagattcgc cattaaagat ccaaaatata 1190701 aacccagcgc gccaataatc gccgggccgt aaatgataat ctgcacccag ccgcacaaaa 1190761 atccccaaaa ctcgccgtac acttcttcaa ggtacgtata aagcccgccg gtttttggaa 1190821 tctgcgttcc gatttccgcg attgtcaaac cgcccgccag tgttaaaata ccgcctaaca 1190881 gccaggcgaa aagcgccatt tttgaatcac ctgaataagc aagcacagcg ccgggcttca 1190941 taaaaacacc agaaccgata atggttccga tgacaagagt aagggcaaac aagaggccta 1191001 tctctttttt caaaccgttg tcttcagtat gcatgtcctt aacctcctat gatgttgaag 1191061 cttcatgttg aagaatctat tttttcatat tgtaaaccct attttagaaa agtgaaataa 1191121 aataaatttt ctgattttcg aaatttgctt tgtgtacagc agataaaact gtagaaatac 1191181 ctgttttaat ggtctataaa cgaataaaat tcataatttt tatttacaaa gttcgtgttt 1191241 tatgtattag gattttagcc ggtacagagg ggagatgaga attcagaaaa tgaacgaacc 1191301 ttcggtgaag ctgatatgtt gactttctca tgcgaataaa atactttgtt attagaacaa 1191361 taaatataca attatgatat gatatctcga aatcgagata aaataacctg gagggacagc 1191421 atatgaaagt taacggcatt caccacgtat cggcattaac ggccgacgca caaaaaaact 1191481 tggatttcta taagaaagta ttaggattaa agctcgtcaa aaaatccgtc aatcaggatg 1191541 aaccgacaat gtaccatctg ttctacggag atgaagtggc aaacccggga actgagctga 1191601 cgtttttcga gattccccgc attgcaccgt ttcatgcggg aacaaacagt atttcttcta 1191661 ttggattgcg cgttccaggc acagaagccc tgcattactg gaaagaacgt tttgaagagc 1191721 agcaagtaac gcacagcggc atctccaaaa gagccggacg tgacatattg gcatttcaag 1191781 atcatgaggg gcagcgactt gtgctgactg ctgatgagga aggaaaagga tatggcctgc 1191841 ctgttaaaca gagcggcatt ccggaagaat tttcgtttcg cgggttaggg ccggttgaac 1191901 tgactgtgcc atatgctgaa ccaactttac acgtattgac gaatattctt ggatttacag 1191961 aaatcagccg tgaaccagtc gaagggcaag gaaccgccgt tattctggaa tcaggagaag 1192021 gcggtgctgc aacggaaatc catttaatag aaagaaacga tcttccgcga gagcgtcaag 1192081 gcaaagggag tgttcaccac gtcgcatttc gggtaagaga tgaagaagaa cttgccgggt 1192141 ggcaccggat catcagccgc gaaggcttta gcaattcagg catagttgag cgctactatt 1192201 tcaaggcgct gtatttcaga gaaccgaacg gcattttgtt cgagttatca acagacggac 1192261 cgggctttat ggtagatgaa aatcttgatg agcttggcca aacgattgct cttccgccat 1192321 atctagagca tcgaagagca gaaattgaag caaaattgaa accgatccaa taaattgtga 1192381 ttcttttgcc ttccggcgcc gccggagggc tttttttatt accataatta attttgacct 1192441 aaacagcatg ccttattagg gaggaaatat cagatgctga ttgggagaaa tggcttaaaa 1192501 ccctttgcaa atatgggtga ttggtatgga atggcctcgg caaaaatatt gtctttgttt 1192561 attaatagtt tattcatatt tgcttgttac actatttcaa agttagacaa aaaggagtga 1192621 aaaataagtg gaaaagaaaa aacgcgagct ggatatcgtc ctcctcctca ttttgctcgc 1192681 atctgcattc ttaaatatct ataacatttg gaaggacgac acggtgaatc cttattacac 1192741 cgcggcagtt acaagtatga tgcaaagctt tcataatttc ttttatgctt cgttcgatgc 1192801 tgccggcttt ataacagtag ataaaccgcc tgttacatac caaatccaaa cgatcagcgc 1192861 actgatattc ggtatgcacg gctggagcgt catcctgcct caggcacttg ctggtgtagg 1192921 ttctgtcctt cttatgtact tgctgataaa gccgacattt ggaaaaacgg cggcgcgtat 1192981 tgcctcattt gttatggcat gtacgccgat agctgtagct gtagcacgta caaacaatgt 1193041 tgatgcatta ctggtatttt tcttattgct tgctacatgg cttctcttta aagcgatcag 1193101 aaaaggaaag ctgatctggc tgttagcagc atttttcgtt gttggagtag gttttaatac 1193161 aaaaatgctg caggcttaca tgattttacc ggctttctta ttgttctatc tgattgcggc 1193221 aaacgccaca atcaagaaaa aaatcgtttc attggtaagt gcgttagccg tattagcagc 1193281 cgtttcgtta tcgtggccgc tcattgttga caatatccct gcaagcaagc ggccttatat 1193341 cggaagcagc caaaccaact ctgttttgga attggctttc ggctataacg gaatccagcg 1193401 gctgacaggc caaaattcag gcggcggcca gggtgcgcca aacaaagacg cttcaaaaga 1193461 aatgtcttct tctgataaca ctcaagcacc gcctaatcag tcatcaagca acagctcatc 1193521 aagcgatggt aaatcctcaa atggcaatat ggcggcgcct ccatccaatg gccaaatgcc 1193581 aagcggcggt caaggaggcc ctccaagcgg cggagatggc ggccaaggcg gacccggcgg 1193641 agacggaggg aaaggcggta caggaaccgg ttcgaaaatg caatcaggtt cagggatgtt 1193701 tggaacggga acacctggtc cactgcggct tttccaacaa gagttatctg atcaaatcag 1193761 ctggcttctg ccatttgcga tatttggaat cgcaggctta ctgatcgctg gcgcaagaga 1193821 aagaagaaga ttatctgtag agcagaagga aacggtgttc tgggttgcgt ggcttgtacc 1193881 gattgccgga ttcttcagtg tcgcagaatt tttccatcat tattatctca tcatgctggc 1193941 accgccgatt gcggctcttg tcggtgcggg gtgggtcgct cttgttcatc tgtaccgcaa 1194001 tcagacaggc tggaaagcat ggcttttgcc gggagcaatt attgcgacaa ctggatttga 1194061 attgtttatt ctcagaaact acaacgatca aatcggtgtt ggatggagta tcggggtagg 1194121 tgttatcggc gtgttgtcag cgattgcttt gctgctgttt aaacagcgcc aaaaaccgtt 1194181 cagttattat gtttcacttg cagctctcct cgcattgctg gtgatgccga tgtattgggc 1194241 aagtacaccg cttctgtacg gaggcaacag ctcactgcct gaaacaggcc ctcaactcgc 1194301 atcaatgagc ggaaaaggca tgggaatgtc tgatgcgact gtaaatgaaa aactgatcaa 1194361 atatctagag gagaataact ccggagctga atacctattc gccacaaccg attcgaacac 1194421 agcggcacca tatatcatta aaacgaaaaa agctgtcatg gctattggtg gatacagcgg 1194481 ttctgacccg gcaatcacac tgactcaatt caaaaaactt gtaaaagaag gaaaagtgaa 1194541 atacttcttg gcttctggaa tgggaagagg cggaaacaat gacattgttg aatgggttga 1194601 gaaaaatgga aaagaagtag catcagaaaa atggcaatca agttctgatc aaaaaacaga 1194661 aaatactgat tcagctgata catcaagcag caaggcttca ggtgaaaacg gcaaaatggg 1194721 cggacctggc ggaatgaatc agtcagcaac attatacgaa ctacatgctg atgaatagga 1194781 ggcaaaaaca tgagcagaca tattcaatat tcaattgttg tacctgtgta taatgaagag 1194841 cttgtcattc atgaaaccta tcagcgctta aaagaggtca tggatcaaac gaaggaaaac 1194901 tacgagctgc tttttgtcaa cgatggcagc aaagaccgca gtattgagat tttaagagag 1194961 cacagcctga tcgatccgag agtgaaaatt attgattttt caaggaattt tggacatcag 1195021 atcgccatta cggcaggtat ggattatgca caggggaatg caatcgtcgt cattgacgcc 1195081 gatttgcagg accctcctga actgatttta gaaatgattg aaaagtggaa ggaaggctat 1195141 gaagtcgtgt acgccgtacg gactaaacga aaaggggaaa cctttttcaa aaaacaaacc 1195201 gcggctatgt tttaccggct tctcagcggt atgacagata ttgatatccc gattgatacg 1195261 ggggattttc gcctcatgga cagaaaagtc tgtgatgaaa tgaagagatt aaaagaaaaa 1195321 aatccatttg taagagggct agtcagctgg gtgggtttca aacagacagc ggtcgagtat 1195381 gtacgtgatg aaaggctcgc cggagaaaca aagtacccgc tcaagaaaat gctgaagctg 1195441 tcaatggacg gcatcacgac attttcacat aaaccgctga agctggcaag ctatgcgggg 1195501 attttaatgt caggtactgg atttctgtat atgtttatcg tgctgtatct gaagctattc 1195561 acagacagca cgattaccgg ctggtcatca cttattgtga tccagctcct gttcagcggc 1195621 attgtccttc tgattttggg cgtgattggc gaatatatcg gcagaatcta cgatgaagcc 1195681 aaagacaggc cgctttacat cgtccaaaaa tcgtatggaa ttgaaaataa aagactctat 1195741 agagaccagc atatgtcata acctcaaacc ccctgtccgt aatggacagg gggtttttat 1195801 gctctgagca cgatctaaag caaaagatgc tgatagatat atggaaattg ggtaaagaag 1195861 agattgtgag cttgtactgc ggttcagtca tgctgaaata aaaacagcaa aacttaaaga 1195921 tttcgtcctc ggctttgctg catgtcagct gttatattgg ggggctttta agaaacgcat 1195981 gattagagcc gtaccagtta tgtttaatag aatactcgta cccaatacaa ttccccacgt 1196041 caacgtcgat tcagagagaa gaaagctcag caaaagaaaa gccaatcctg cgcagatcat 1196101 acccagtccc acggttttca tgttcatgcc tcctagcaaa cgatgtttct agcatctgat 1196161 gtgaatgatg tcaatctgta tgatatacgg atatctcgtc agaaagtttc atagaacaat 1196221 taggtctttt atctaataaa aagcctcaga ccgcttttac ggcctgaggc attatgtctt 1196281 acgaagtttt ctcttctttt tgatccagtt taattttttt cgtcatttct ttgccgtttc 1196341 ggagaatttt cacttcaacg gtatcaccga tctttgcgtc tttatataag atattgcgca 1196401 attcactgcc tgtatcaatt tctttacctt ttaggccgat gataatatcc tccgctttta 1196461 atccggcctt ttcagcagga gagcctgaag cgacctcacg gatgtaaacg cctttattca 1196521 gctggctgcc gaacaggccg agtgtgcctt cttggtaatt ttgcggcact tgctctagat 1196581 caagcatgct gacaccgata tatggacgtt caatttgtcc tttagacagc aattcttcag 1196641 caatcggttt tacgtcattg cttggaatgg cgaatccgat accctcaaca tcatcctcac 1196701 tgattttcat actgttaatg ccgacaattt tgccgtctgt atttaacaaa ggaccgccgc 1196761 tgttacctgg attaattgct gcgtctgtct gaatgacgtt aatgctcgtt tcgccggctg 1196821 atgtagacat tgaaaccgtt ctgtccacgc cgcttacaat tccttgtgtt actgtgcggg 1196881 acaggtcttt tccaagcgga tccccaatcg caataacggt ctcgcctgtt ctaagatcag 1196941 atgaatcacc gaagtttgcc acttttgtga cgtggtcatc actgatttgg aggacggcta 1197001 aatcagttaa cgagtcactg cctaccagct ttgcagtaac ctcagtgccg tcatataaag 1197061 ataccttcag tgatgatgcc ccttctacga cgtggttatt tgtaatgata taagccttgc 1197121 cattctcttt tttgaaaatg acacctgacc ctgaaccgct ttctgtatct tcgctggaat 1197181 cagaagaact agagccgaac aaagagctgt ttgattgtgc ctgaagattt gtaataccga 1197241 caatcgctgg tgaaaggtct tctaccatat ctgagatttt agaagagtcc tcgctcttga 1197301 atgcagatga gctgcttgag ctttttttag attcagagga ggtgcttgtt gctgtaacag 1197361 attgcgtttg ctgctggctg gatgattgtt ttgcagtgtc ctgagaatca tggtcaccaa 1197421 gcggtgtaaa cgtgtaaatg ccaagagcaa gactgccgcc gatcactccg ccaagcaacg 1197481 gtctgaacca tccgaatcct cgttttttct tctcctgatc atgaatgaca ttgcgggccg 1197541 agtaggaggc gctctgatcg ttctctttcg ttaaaaagac ctcattctca ttacctttcg 1197601 ttctgttttc atcacgatag ttatccatca tgttcactcc gtttctctat tttcacatgt 1197661 ctatttatat tgataggttt atgacttgag tttatcataa acaaaaactg tgggataaaa 1197721 atgaaaagat tatgggaaat tgtgaaaaag tgcggaaaac ggtacacttc atattgtata 1197781 tgaaaggact gagtcgatgg aacagattgg attgattgga tatggcagca tggcggatat 1197841 gatcgctaga cagctgttga aacatgaaca aataaaagag aatgagctat ttattgagac 1197901 gagaacgaag ggggagcggc tgcgggcact catgtcagat tatccaaacg tatcggctga 1197961 tccgttggag aattgggcaa atacgtgcca attgattttg atatgcgtcc cgccactcca 1198021 tgtcatcgaa acaatgcgcc gtctgtaccc gtatgtgaac agaaatactc acatcgtatc 1198081 catagctgcc ggtgtgccgc tgcgtctttt ggaggcagaa acagaagccg gtatctcacg 1198141 tgttattcct gccattacgt ccgaagcaga agccggcatc tcacttgtcg ttcacagtga 1198201 agcactggct gcagagaaaa aagaacgtct gaatgaattg ttatcggttt tcagccgtgt 1198261 acgggaaatc aaagaatcga atttagatgt ggccagcaat ttaacgagct cggcaccggg 1198321 attcatagct gcaatctttg aagaactggc actgtctgcc gtcagaaaca gcagcctgtc 1198381 caaagaagaa gcctttgatt ttctgattca ttcgctatac ggaactggca agatgctgat 1198441 cgaaaaaaat atgtctttcg aggagacgct ggaacgtgtt gcaaccaaag gcggaataac 1198501 gggagaggga gctgaggtga tacacgcctc tgtgccggac gtttttgatg aggtatttga 1198561 aagaaccctg agaaaatatg aactgcttac agaacaggtt ggtaaacaaa catgaatcct 1198621 tgaaagagga ttcttttttt atcactgaat gattgagatt tttcccagtt atattgcatt 1198681 tttcctcttt ttttaatata atttgttaga atattcataa tttagtaaaa aaggaggagc 1198741 gttatgaaat tgtacatgtc agtagatatg gaaggtattt cgggtcttcc ggacgatacc 1198801 tttgtggatt ccggcaagcg gaattatgaa cgcggacggc ttatcatgac tgaagaagca 1198861 aactactgta ttgctgaagc gtttaacagc gggtgtaccg aggtgctggt caatgacagt 1198921 cattcgaaga tgaataatct gatggttgaa aagcttcacc ctgaagcaga cttgatttct 1198981 ggtgacgtca aaccattttc aatggtggag ggactggatg atacgtttag aggcgctttg 1199041 tttctcggtt atcatgcgag agcctcgact cctggtgtca tgtcacacag catgattttc 1199101 ggcgtccgtc atttttacat aaacgatcgg cctgtcggtg agcttggatt aaatgcatac 1199161 gttgccggtt attatgatgt cccggtatta atggtagccg gggatgaccg ggcggcgaag 1199221 gaagcagaag agcttatccc gaacgtgacg acagccgcag tcaaacaaac catttcaaga 1199281 tccgcagtga agtgcttgtc gcctgcgaaa gccggacggc tgttgacaga aaaaaccgca 1199341 tttgccctgc aaaacaagga caaagtcaag ccgctcacac cgcctgacag gccagttctg 1199401 agcattgaat tcgccaatta tggccaagca gaatgggcga atctgatgcc gggaacggaa 1199461 atcaagacgg gaactacaac cgttcaattt caggcgaagg acatgcttga agcctatcag 1199521 gcgatgcttg tcatgactga gcttgcgatg cggacatcat tctgctaaag gggtgtttta 1199581 ggctttggcg cgatacatga taaagcgttt ttgggcaatg gcagctacga ttttggtgat 1199641 taccaccctg acttttgttc tcatgaaggt cattcccgga tctcctttta acgaggagag 1199701 aggcacaaat gaagccgttc aaaaaaatct cgaagcctac tatcacttag acgatcctct 1199761 cattttccaa tacattttct acttaaaatc catcattaca ttcgatttcg gaccttcaat 1199821 taaaaaaccg tcggacagcg taaatgatat gctggaacgc ggatttcccg tttcctttga 1199881 gcttgggatg acagcgattg tcattgctgt gatttctggg ctggtgctgg gcgtaatcgc 1199941 tgcactccgc cgcaatggct ttttggacta cgccgcgatg agtcttgcag tactcggcat 1200001 ctccatcccg aattttattc tggcaacatt gctcattcag caatttgctg tcaatctcaa 1200061 actatttccc gctgcgacat ggacgagccc gattcatatg gtgcttccga ccgcagcgct 1200121 tgctgtaggg ccaatggcga tcattgccag gctgacacgg tcgagcatgg tcgaagttct 1200181 gacacaggat tatatccgca cagcaaaagc aaaagggctt tctccgttca aaattatcgt 1200241 aaaacacgca ctcagaaatg cactcatgcc cgtcattacc gtcctgggca cactcgtcgc 1200301 cagcatctta acaggaagct ttgtcattga aaaaatcttt gccattccgg gaatgggaaa 1200361 atattttgtt gaaagcatta atcagcggga ctaccccgtg attatgggaa cgaccgtttt 1200421 ttacagcgtc attctgatta tcatgctgtt tttggtcgat ttggcctacg gtctcttaga 1200481 cccgcgcatt aaactgcata agaaagggtg aagcgtgtga atctccctgt acaaacggat 1200541 gaacgccagc cagaacagca caatcaggtg cctgatgagt ggtttgtctt gaatcaggaa 1200601 aaaaatcggg aagccgattc ggtcaagcgg ccgagtttgt catacacgca ggatgcctgg 1200661 aggaggctga aaaaaaataa attagcgatg gccggactct ttattctttt atttcttttt 1200721 gtcatggcag ttatcgggcc ctttttatcg ccccatagtg tcgtacgcca atcgctgaca 1200781 gaacaaaatc ttccgccctc agccgatcat tggttcggca ccgatgaact cggccgggat 1200841 gtgtttaccc gaacatggta tggcgcgaga atctcgttgt ttgtcggcgt gatggcagca 1200901 ctgattgatt ttttgatcgg tgtcatttac ggaggcgttg ccggctataa aggcggcagg 1200961 attgacagca ttatgatgcg gattatcgaa gtgctgtacg gactgccgta tctgcttgtt 1201021 gtcattttgc tgatggtgct catgggaccg ggactgggca cgattattgt ggcgctgact 1201081 gtgaccgggt gggtcggcat ggcgagaatt gtaagaggcc aggtgcttca gattaaaaat 1201141 tatgaatatg tactcgcctc gaaaaccttt ggcgcgaaaa cctttcgcat catccggaag 1201201 aatttgctgc cgaatactat gggagcgatc atcgtacaaa tgacattaac cgtacctgcc 1201261 gccatattcg cagaatcatt tttaagcttt ctcggcctgg gcatacaggc tccgtttgca 1201321 agttggggcg tgatggcgaa tgacggcctg cctacgattt tatctgggca ttggtggcgc 1201381 ctgttttttc cggccttttt catatctctg acgatgtacg cgtttaatgt gctgggggac 1201441 ggattgcagg atgcgcttga ccctaagctg aggaggtagc tgtatggaaa aagttctgtc 1201501 agtccaaaat ctgcacgtgt cttttacgac ttacggcggg acggttcagg cggtcagagg 1201561 ggtgagcttt gatttgtata aaggagaaac ctttgcgatc gtcggcgaat ccggctgcgg 1201621 caaaagcgtt acctcccaaa gcatcatggg cctgcttccg ccttattcgg cgaaggtgac 1201681 agacggcagg attctattta aaaacaaaga cctttgccgt ctctctgaca aagaaatgag 1201741 aggtataagg ggagccgaca tttctatgat ttttcaagac ccgatgacgg cgttaaaccc 1201801 tacgctgact gtcggcgacc agctggggga agcgctattg cgccacaaaa aaatgagcaa 1201861 aaaagcggca cggaaagagg tgctttccat gctgtcattg gttggtattc cagatcccgg 1201921 agagcgccta aagcaatatc cccaccaatt cagcggcggt atgagacagc ggattgtcat 1201981 tgcgatggcg ctgatttgcg agcctgatat cttaattgcg gatgaaccga ccaccgccct 1202041 ggatgtaacc attcaggcac agattttaga gctgtttaaa gagattcaga gaaaaacgga 1202101 tgtgtctgtc attctgatta cgcacgattt aggggttgtt gcccaggtag ctgacagagt 1202161 cgcagtcatg tatgccggga aaatggcgga aatcggcaca agaaaagata ttttttatca 1202221 gccgcagcac ccatatacaa aaggcctgct gggctctgtc ccgcggctgg atttaaatgg 1202281 cgctgagctg accccgattg acggaacgcc gccggattta ttttcgcctc cgccgggctg 1202341 cccgtttgcc gcccgctgtc cgaacaggat ggttgtgtgt gacagggtgt acccgggcca 1202401 gacgatcaga tctgactcgc acaccgtcaa ctgctggctg caggatcaac gagcagagca 1202461 tgcggtgctg tcaggagatg cgaaggattg aacatgaaaa gggggaagag gatgaaacga 1202521 gtgaaaaagc tatggggcat gggtcttgca ttaggacttt cgtttgcgct gatggggtgc 1202581 acagcaaatg aacaggccgg aaaagaaggc agtcatgata aggcaaaaac cagcggagaa 1202641 aaggtgctgt atgtaaataa tgaaaatgaa ccgacttcat tcgatccgcc gatcggcttt 1202701 aataatgtgt catggcagcc gttaaataac atcatggagg ggctgacgcg tcttggcaaa 1202761 gatcatgagc ccgagccggc aatggcggag aaatggtctg tttcgaaaga taataaaact 1202821 tacacattta cgattcggga aaatgcgaaa tggacaaacg gagatcctgt aacagccgga 1202881 gacttcgaat acgcgtggaa gcggatgctt gatccgaaaa aaggcgcttc atcggcattc 1202941 ctaggttatt ttattgaagg cggcgaagca tataacagcg ggaaagggaa aaaagacgat 1203001 gtgaaggtga cggcaaagga tgatcgaacc cttgaagtta cactggaagc accgcaaaaa 1203061 tatttcctga gcgttgtgtc caatcccgcg tatttcccgg taaatgaaaa ggtcgataaa 1203121 gacaatccaa agtggtttgc tgagtcggat acatttgtcg gaaacggccc gtttaagctg 1203181 acggaatgga agcatgatga cagcatcaca atggagaaaa gcgacacgta ttgggataag 1203241 gatacagtga agcttgataa ggtgaaatgg gcgatggtca gtgacagaaa tacagattac 1203301 cagatgtttc aatcagggga acttgatacc gcttatgtcc ctgctgagct gagtgatcag 1203361 ctgcttgatc aggataacgt caatattgtt gaccaggcgg gtctctattt ctatcgattt 1203421 aatgtcaaca tggagccgtt ccaaaatgaa aacatcagaa aagcctttgc gatggctgtg 1203481 gatcaagagg aaattgtaaa gtacgtcacg aaaaataatg aaaaaccggc gcacgccttt 1203541 gtatcgcctg ggtttacgca gcctgacggc aaagatttcc gtgaagcagg cggagacctg 1203601 atcaagccta acgaaagcaa agcgaagcag ctgctcgaaa agggcatgaa ggaagaaaac 1203661 tataataagc ttcctgcgat cacgcttact tacagcacaa agccggagca taaaaagatt 1203721 gccgaagcta ttcagcaaaa attgaaaaat agccttggag tcgatgtgaa gctggccaat 1203781 atggaatgga acgtattttt agaggatcaa aaagcgctga aattccaatt ctctcaaagc 1203841 tcatttttgc ctgattatgc agaccctatc agttttctgg aagcctttca aacgggaaat 1203901 tcgatgaacc gcacaggctg ggccaataaa gaatacgatc agctgatcaa acaggcgaaa 1203961 aacgaagccg atgaaaaaac acggttctct cttatgcatc aagctgaaga gctgctcatc 1204021 aatgaagcgc cgatcattcc ggtttatttt tataatcagg ttcacctgca aaatgaacaa 1204081 gtaaaaggaa ttgtccgtca ccctgtcggc tatatcgatt taaaatgggc agataaaaac 1204141 tgatggaggc gattgaggaa atactgcttc tttatgcgaa ggagcggtat tttttctctt 1204201 tcttgcacgt atacgtaggg tgcagagcaa atgaaaggag tgttttcgtt gaattacaag 1204261 ccgaaagcgt tgaacaaggg tgatacagtc ggagtgatcg cgcccgcaag tccgccggat 1204321 ccaaaaaagc ttgacaccgc gcttttattt ttagaagagc tcggtcttca ggtgaagttg 1204381 ggcaaggcgc tgaaaaacca gcacggctat ttagcgggac aggatgatga gcggctggcg 1204441 gatctccatg agatgttcag agacgatgag gtaaaagcag tgttgtgcgc atgcgggggt 1204501 tttgggacag gacgtatcgc cgcgggcatt gatttcagct tgatccgcaa acaccctaaa 1204561 atcttttggg gatacagcga tattacgttt ttacatactg ccattcatca aaacacaggt 1204621 cttgtcactt tccatggccc gatgctcagc acggatattg gccttgacga cgttcacccg 1204681 ctgacaaaag cgtcatataa gcagctcttc caggagacgg aattcaccta tacagaagag 1204741 ctttctccgc tgaccgagct tgttcctgga aaagcggaag gcgagcttgt cgggggaaat 1204801 ctgtctttgc tgacgtctac actgggcacg ccatttgaaa ttgatacgag aggaaagctt 1204861 ctgtttattg aagatattga cgaggagcct tatcaaatcg accggatgct gaatcagctg 1204921 aaaatggggg ggaagctgac ggacgcggcg ggaattctag tttgtgattt tcacaattgt 1204981 gtcccggtga agcgagagaa gtctctctcg cttgagcagg tgctggaaga ctatattatt 1205041 tctgcgggca ggcctgctct gagaggattt aaaatcggcc actgctcgcc aagtattgcc 1205101 gttccgatcg gtgcgaaagc tgctatgaat acagcagaaa aaacagccgt aatagaggcg 1205161 ggcgtttcag aaggggcgct gaagacatga aaatcattcg aatcgaaaca agccgaatcg 1205221 ctgtcccgct gacaaagccg tttaaaaccg cacttcgcac tgtgtatacg gctgaatcag 1205281 tcatagtaag gattacttat gacagcggtg cagtcggatg gggagaagca cccccgacgt 1205341 tagtgattac aggagacagc atggatagca ttgaaagtgc catccaccat gtgttgaagc 1205401 cggcattgct tggaaaaagc ctggcgggct atgaggccat tctgcacgac atccagcatc 1205461 ttcttacagg aaatatgagc gcgaaggctg ctgtagaaat ggctctatac gacggctggg 1205521 cgcagatgtg cgggctgccg ctttatcaaa tgcttggcgg atatcgagat acgctggaaa 1205581 cagattatac tgtcagtgtc aactcacctg aagagatggc agctgatgcc gagaattatc 1205641 tcaaacaagg ctttcaaacg ctgaaaataa aggtcggaaa agatgatatt gcaacagata 1205701 tcgcccgtat ccaggaaatc agaaaacgtg tcggatcagc tgtgaaactg cgtttagacg 1205761 ctaatcaggg gtggaggccg aaggaagcgg taactgccat tcggaaaatg gaggatgcgg 1205821 gcctaggcat tgagcttgtc gagcagcctg tccataaaga tgatctcgct gggcttaaaa 1205881 aggtgacaga tgcaacagat acgccgatta tggctgatga aagtgttttt acaccgcgcc 1205941 aggcgttcga agttctgcaa acccggagcg cagacttgat caatattaaa ttgatgaaag 1206001 cgggcggcat cagcggagca gagaaaatta atgccatggc ggaggcctgc ggggtggagt 1206061 gtatggtcgg cagcatgatc gaaacgaagc tgggcattac ggccgcggcg cattttgcgg 1206121 caagcaagag aaacatcaca cgctttgatt ttgacgcgcc gctgatgctg aaaacagatg 1206181 tattcaatgg cggcataaca tatagcggca gcacgatttc gatgcctggc aaaccgggcc 1206241 tcggaatcat cggggctgcg cttttgaaag gggaaaaaga gcaatgatgc acactgtcat 1206301 atcagcagtg gccaacatct ggacagcgcc tgattcacct cgtccgtctg atcaattcat 1206361 gcttcaaccg actgtaatga tcagagactg gctggagcgc atgacgtatg atgaacggct 1206421 tggattatgt acagacaatg taatccaaac tcaggttctc tttggcgaaa aggtacttgt 1206481 gacggcggaa cagggggaat gggtttctgt gatcgtgcct agccagccat cccgaaagga 1206541 tccgcgcgga tacccgggct ggatgaaaaa gtaccagctg gaaaaaacaa agcccatcca 1206601 tacacaacac gatgtgatga tcagcaaacc tgctgccttt ttgtacagaa gcaatgggga 1206661 aaaggagatc gaattaagct ttttgacagt tctgcccctt attgcaaaag aaaacggata 1206721 ttttaaggtt tcgaccgttt ttggggaaag gtttgtgagg caaagtgatg cagtgcctgt 1206781 cagccaacag aaagggactg ctgaagacat cattcaaacg ggtgcgtttt ttcttggcct 1206841 tccctacctg tggggaggga tcagcgggtt tgggtttgat tgctccggat ttatgtacag 1206901 tatatttaag gcgaatggat acagcatccc ccgtgatgcg ggagatcagg ctaaggcagg 1206961 gaagggtgtc ccgcttgatg atatgaaagc cggtgatctg ctgttttttg cttatgagga 1207021 aggaaaagga gcgattcatc acgtcggtct gtatgtaggc ggcgggaaaa tgcttcattc 1207081 tccaaagaca gggaagtcaa tcgaaatcct cacattaaca gagacaatct atgaaaaaga 1207141 attatgtgcg gtgcgccgct gtttttcaga ataaggaggg agacaaatga ggcgactgcc 1207201 tttgttagag gtcagccagc tgaaaatgca ttttgacgca gggaaaaagc ggacagtcaa 1207261 agctgtcgac ggggtcacct ttcagattcg tgaaggagaa acgttcgggc tagtcgggga 1207321 atcagggtgc gggaaatcaa ccttggggag agtgctgatg cgcctttatc agccgacaga 1207381 aggaagcgtg acataccgcg gcacaaatct tcatgcacta agtgaaaaag agcagtttgc 1207441 cttcaaccgc aaactgcaga tgatttttca ggacccttat gcttcactta acccgcgcat 1207501 gaccgttcga gaaattattt tggagccgat ggagattcat aatctctaca atacccataa 1207561 agcacggctt ctcgtcgtgg acgagctgct tgaggcagtt gggcttcacc ccgattttgg 1207621 cagccgttat ccgcatgaat tcagcggcgg gcaaaggcag agaatcggga ttgcgagagc 1207681 actgtcgctg aatcctgaat ttatcgtggc ggacgaaccg atttctgcac ttgatgtctc 1207741 tgttcaagcg caggtggtca acctgctgaa gcggcttcaa aaagagaaag ggcttacgtt 1207801 tttattcatt gcccatgatc tttcgatggt gaagcatatc agtgacagga tcggtgttat 1207861 gtacttagga cacatgatgg aaattacaga gagcggcacc ttgtatcgtg aaccgctcca 1207921 tccctataca aaggcgcttt tgtcctcgat tccgattcca gatcctgaat tggaggacaa 1207981 gcgtgagcgt attctcttga aaggggagct gccgagcccg gtcaatccgc caagcggctg 1208041 cgtgtttcgt acccgctgtc cggaggcgat gcctgaatgt ggagaatctc gtccccagct 1208101 tcaagaaatc gaacccggcc gttttgtcgc ttgccatttg tatcgaaatg ctgaaacgaa 1208161 ggaaaaagta agataaataa aaagagtggc tcctttttac tagagccact ccatttgttt 1208221 atacttgatg taaaaacttt acacaaaccg ggtaagggac agaaaccgtt gatgggagga 1208281 gtgtcaatcg gccggtttct ttgtctcttt caaacaagac aaggttgcct gtttcttcat 1208341 ttgaagcaac gaggaaccct tccgttgggt caaatacaaa gtcacgaggc cagtttcctt 1208401 ctgtcgacac tctttctacg aaagccagct ctcctgaata ttgattcact tcaaatacgg 1208461 cgatactgtc atggccgcgg tttgcgacat aaacaaaacg tccgtcctgc gtgacatgta 1208521 ttgcgcttcc ctggctgtta tctgtaaaat catcagggat ggcagaaacg acttggattt 1208581 ctctaaattc gccggctgtc gggttgtatt caagcgcaat cacttcattg cttaattctg 1208641 tcatgacata agcgtatttt tctttcggat gaaaagcgat atggcgaggt cctgcaccgg 1208701 gagcgaagga atggcttccg gattcagtca acacaccgtc tttaagctta taggtgtaga 1208761 gcttatctat acctaaatca accgctacca cataattgtg ttcaggtgtg aaccccgcgt 1208821 agtgtgtatg cggtttttct tgtctttcgt gcggcccttt tcctgtgtga gcggcctctg 1208881 aaacaggtga ttgcaagctg ccgtcttcct gaaccggaaa aacgtgtacc ttcccgctgt 1208941 gataattggc agtcagtacg aattgatttt gatcatcaac gcttacgtgg catggcgaag 1209001 ggccatcaat taactgatga ttcagaaatg tcaattcgcc gctgttttta tcgatttgat 1209061 aggcagcaac tccgccttgg ccgtctgctt tttcgatgga ataaaggatg gtgttgtttt 1209121 tattcgtcgc cacatatgtc gggttgccca gcttagcggc cagctttggc tcgctgagtg 1209181 cttttttctc agtatcaagc tcaaatgaat aaattccttc gcttccgcct tttgtatatg 1209241 ttcccacata tcctatgtat tttgtcatgc gatttccccc ttaaaaatga tgtcacctct 1209301 atattaacgt atcttgataa aataagctgt tcaaaacatg aaaaagggga agattcttca 1209361 ttcgcctcga atcagcggca ttgtgcagca cctgaaggag ccgcctgatt taataatttc 1209421 tgacaggtca atttcgataa tgtgatagcc tcttttcgat agctgttgat tgacatggcg 1209481 gttgccaggg agactgatga tcgttttttt tccgattgaa aggacgttgg tgccaagcgt 1209541 aaattgttcg tcctcgggca cctcaataag atcataacgt tttgccagca tatcggctgc 1209601 atctggctca atggcctgtg aataaattaa cgcttcgctt tcagatataa tgttaaatac 1209661 gcagtccaaa tgcaaaaatt tttcatgaag cttcactgga acgatcgtat attcaggaag 1209721 tgcctcttct agctggccga tagctgaaat gtcggtgcgc tggctgattc cgacatagac 1209781 aatgtcatca tcgataatga cgtctccgcc ttcaatactc gtatcaagca tgcgggtgta 1209841 agagatacct tggctgtgaa aaaaatcttt tataacggct tcttctcctt ggcgaatcgg 1209901 ttcagtcatg cttgacagaa aggctttttc tccgatgaca aatcctatgt ccctagtaaa 1209961 aacctgttct gggagtccgt cgcgaacggg caaaaggacg acctcaacgt tgtgtgacct 1210021 aagtgcctcc actaagcggc tgtgctggtc gttagcggtt tttacatgaa tattgtcatc 1210081 ttcaaaatgt ttttgtgttt cgtttataac atcttttatg gtcatgtgct caggtttgca 1210141 taagatcact ttttgaagtg tgccgtattc cgttcggcat accgttttgt gctgagattt 1210201 cgggatggat acgtccattt gtttttcctc ctaaagtgtg aagaatacat ttattattcc 1210261 ctcatcatga aaatcattaa accattttaa attttagaca aatggaagag aatattgttt 1210321 aataggagaa tataagtgca tttagctaaa agatcagaca tcaaagggga gaaaggtatg 1210381 gaaacaccgg aaacaagatt ttgtaaagag tcaaaggttg tgaaaaccag cagggtgttc 1210441 ccgcttgaca cgaacaacca taatacgctg tttggcggaa aattaatgag ctacatagac 1210501 gacattgcct ctatttcagc ggcgcgccat tgcagacgtg aaacggtaac agcttcaatg 1210561 gattctgtag attttttaaa gccgatcggg caaaaggatt ctgtctgcct agagtcatat 1210621 gtgacatggg tcggcacatc ttccatggaa gtatttgtga aagttattaa ggagcatttg 1210681 atgactggcg aacgggaact cgctgccaca tcctttttga catttgtcgc attagattca 1210741 aatggcaagc cggtgcctgt accgagggtt gtaccggaaa cagaagaaga aatcatgctg 1210801 cataatacag ctgtacagcg tgctaatgaa cgtaagaacc gcaagagaca cagccaggcg 1210861 cttgcaaatg cgctcggaac tgataagcct tggtgaacgt taaacccaaa acataagttg 1210921 ttttgggttt ttttgtactt ttcaatggtg attattacaa tggttagtcc gtttttgcta 1210981 ggggattcta taaaaaagca acaaatgtca tgttaaattg ataattttgt gacaacttta 1211041 ttaaagattc attttagata tatcttttat tcgtaagatc atgtatttta aagatatatt 1211101 ttaaatacat cttttcgaaa ggattgttta taaaatgtta gataacaaaa caatcgaaat 1211161 tattaaaagc actgtacccg tattgcaaca gcatggagaa acaatcactg gccgttttta 1211221 cgatcggatg tttcaagacc atccagagct tttgaacatt tttaatcaaa caaaccaaaa 1211281 gaaaaaaaca cagcgaactg cactggcaaa tgccgttatt gcagctgcgg caaacattga 1211341 ccaattagga aacatcattc cggttgtcaa acaaatcggc cacaagcacc gcagtatcgg 1211401 aattaagcct gagcactacc caatcgtcgg taaatatttg ctgattgcga ttaaagatgt 1211461 attgggagac gctgcaactc ctgacattat gcaggcatgg gaaaaagcgt acggagtcat 1211521 tgctgacgcg ttcatcggaa ttgaaaaaga catgtatgaa caggctgaag agcaagccgg 1211581 cggctggaag gagtataagc cattcgttat cgcaaaaaaa gagcgggaaa gcaaagaaat 1211641 tacatccttc tatttgaaac cggaagacag caagccgtta cctgaattcc aagcagggca 1211701 atatatcagc atcaaagtgc ggattcctga ttctgaatat acgcatatcc gccagtacag 1211761 cctgtctgat atgccgggaa aagactatta tcgaatttca gtgaagaaag atggtgtcgt 1211821 gtcttcctac ttacacgatg ggctgcagga gggagattca atagagatca gcgcaccggc 1211881 aggggacttt gttttagatc atgcatcaca aaaagatctc gttttgatca gtgccggagt 1211941 tggcattaca ccaatgatca gcatgctgaa aacatctgtt tccaaacagc ctgaacggca 1212001 aattctgttc attcatgcgg cgaaaaacag tgaatatcat gcattgcgcc atgaagtaga 1212061 agaagcagca aaacattctg ctgttaaaac agcatttgtg tatcgcgagc cgacagagga 1212121 agaccgtgca ggtgatctgc attttcatga aggacagatt gatcagcaat tcctcaaaga 1212181 actgattgcc aacacagatg cggattacta tatttgcggt tcaccgtcgt ttattacggc 1212241 aatgcataag cttgtatcag agctcggatc agcgccggag tctatccatt acgagctatt 1212301 cggcccgcaa ttaagtttgg cgcagtccgt ttgaacacat acatgaaact cttctccttt 1212361 cagagaagag ttttttattg agatataaga aggcagacaa gcgccggttt ctacatccgg 1212421 acaatcacag acccgctgcc atttgtgcat acacggtttt gctgttcttg cattgttctc 1212481 agcaattcat tgtttacctc aatcgctcta attagttgct tcattcttag ctccaaaccg 1212541 gccagcctgt cgattgtttg ctgctggtag ccctcgggtt ggggagccaa tggcagatca 1212601 aagggccaaa gggtattcga cttctgattt ttcatattgc gtattgcgcc tccaatcggt 1212661 gtcactttct attatgttat gttcaggcga tatgcacgtt cgcctagaca ctgatgcata 1212721 gagggcctgc cacggggcac aataggctca atatgaccag cggatggagg taaagatcgg 1212781 tgttatggat ggtatgggta tttttactga agccagttat cgtattttcg attgcatata 1212841 ttttgtttcg gcttgccggt aaaaaagctg tgtcacaaat gaacaatttt gacctgcttt 1212901 tgaccttcgc aatcggaacc attatcagtg agccgatcct tacatccaag ctgccgatgt 1212961 caatttatta tgcgggtgct tttttggtgc tttatcttat catgagcaag ctctctttat 1213021 ctaataaatg gcgatggctc ctagtcgtga gcccgactgt cctaatccga aacggggata 1213081 ttgatgaacg cggccttcgt aaagaaaggc tgactgttaa tgagctgctc ggaaagctga 1213141 gggaaaaggg ctatgccgac ccggctgaca ttgatcttgc tatcattgaa gaaacgggag 1213201 aagtaagcgt catcccgaaa gaggaagcga gagcggtgca ggtgcgggat ttgaatatgg 1213261 aagctgaacg gaattttatc ccgattccgc tcatactgga tggcgaaatc cttgatcata 1213321 atttgaaata tctccaaaaa aaccgatcct ggctgtttga gaagcttgag gaaaaagggt 1213381 acagccccaa actgctgtct tcgattatcc ttggcacgat gaatgcacgc ggtgatatat 1213441 cccttgattt aaataccgct aatgaaccgc agcatgatcc ttacttatat aaaccgggaa 1213501 ataacaatta agatggctct ctcttgtaat gagagctttt ttctttttta aagggaattt 1213561 ttgtttggtg tcaaatgtac ctagttagga ggggaactga acatgaagga cttatccata 1213621 agaaacgaca tggcgccaac ggtcagtttg ctgtattccg cagtggaaga aaacagtctc 1213681 cgtctggctt ccatcgtaag ccatatgaca cacagtgaac tttactataa ggggcgctgc 1213741 caaacaaaaa acagcacggc tcagcttttg caccatatca caaatgttga tatcagatgg 1213801 gtctggcgta tcaaggaaaa tcggatcccg gaccatattg aacaggcata cggcccgatg 1213861 acagatgaaa gcggacggct gcctgaaccg gtgaatcagc cagacttaga tgaactcctg 1213921 aaaagacatc agcatgtagt agagaagctg aaatcggtat gcttcacttt aactgaaaat 1213981 gctttgaacc agccgctttc cttcgaaggt gacaccgcga cgatacgatg gggaatttgg 1214041 catatggcag atcataaccg ctatcatcag gcacatattg aagctctcaa aaaagaatgg 1214101 aagcaggatg tggcgaagta tgaacgctaa aacgaagctt gtgactgatc gaattcgttt 1214161 gcgctgtatg gaagatcggg atcaagccac tttgtttggg ctgcttttta atgatcctga 1214221 cgtcatgaca tattattccg gtttaaaaga taagaggcaa acccgcgagt gggtcaattg 1214281 gaaccaacga aatgaaaaag ggtacggcgt tagtctgtgg atcgccgaag ataagcggac 1214341 aggggagttt ttggggcaat gcggcatcgt tccccagcag atcgaaaatc aaaccgtaat 1214401 ggaaattggc tatatgtttg cccgccgcca ctgggggaac ggctatgcgc aagaagcggc 1214461 tcgggcctgt ctggactatg gctttaacga gcggcagttc ggcaaaatgg cggctttgat 1214521 tgatccgggt aacaaagcgt ccatacgggt agcggagaaa atcggcatgc attacagcaa 1214581 aacgatcaga aaatggaata aaccgatcgc ggtatatgaa agaaaatctt acaattgaaa 1214641 gatagagctg agtttagtat catgatatca tgtaaagttt tctagggttc cgcatgtcaa 1214701 ttgacatgga ctggtccgag agaaaacaca tacgcgtaaa tagaagcgcg tatgcacacg 1214761 gagggaaaaa agcccgggag agtcaatctc atgtgagacg actgtccggg gtttttttgt 1214821 tttcggagaa tcttaataga tagaaaggaa tgactcaaaa tgaaatgggg attggtcgtg 1214881 cttgccgctg ttttcgaggt tgtttgggtg ataggcttaa agcacgctga ctcagcctta 1214941 acatggagcg gcactgccat cggcatcata ttcagctttt accttctaat gaaggcgact 1215001 cacagtctgc ctgttggtac cgtgtatgcc gtctttaccg ggctcggcac agcgggaaca 1215061 gtacttagtg aaatcgttct ttttcatgaa ccggttggat ggccgaagct attgttaatt 1215121 ggcgtgctct taatcggtgt aatcgggttg aagcttgtga cacaggatga gacagaggaa 1215181 aaaggaggcg aggcataatg ctgcactgga tcagtttatt gtgcgcgggc tgtttagaaa 1215241 tggccggcgt ggcccttatg aatcaatatg cgaaagaaaa aagcgtgaaa tgggtgctgt 1215301 tgatcattgt tggttttgcc gcttcatttt ccttgctgtc gtacgcaatg gaaaccactc 1215361 cgatgggaac ggcttacgcg gtctggacag gaattggcac cgccggcggg gcgcttatcg 1215421 gcatcctctt ttacaaggag cagaaagacg ccaaacggat cttctttatc gcgttgattt 1215481 tatgctcagc agttggttta aaaattctgt cataaattga tttttatcaa atcttcagta 1215541 taatggataa atagtttaga cttacaaaga taagagggat tattcatgaa atcatatatg 1215601 actcagcggt tggacgaata ccgtgacgga aatgaggata aaggtcggct cttggtcagc 1215661 tgccccgatc agccgggtat cgtctctgca gtttccgcgt ttttatttga acacggtgcc 1215721 aatattatag aatcaaatca atatacgaca gaccctgaag gcggccggtt cttcctgaga 1215781 atcgaattcg actgcgcagg cattcgtgaa aaaaaatcat cacttcaggc agcgtttgcc 1215841 tctgttgcgg aaaaattcga catgacatgg agcttaactt tggcgagcga actgaagcgt 1215901 gtcgccattt tcgtttcaaa ggagctccac tgcctgcatg agctgatttg ggaatggcaa 1215961 accggcaacc tgatggcgga gatcgctgtt gtcatcagta accatgagga agcgagagag 1216021 ctggttgagc gcctgaacat tccattccac tatatgaaag cgaacaaaga catcagagcg 1216081 gaagtcgaaa agaagcagct tgaactgctg gagcagtacg atgttgatgt gatcgtgctc 1216141 gcacgctata tgcagattct aactcctgat tttgtttcgg ctcatccgaa tcgcatcatc 1216201 aatatccacc attcattcct gccagctttt atcggtgcga atccgtacaa acgggcctac 1216261 gagcgcggcg tgaaactgat cggtgcgaca tctcattatg tgacaaacga tcttgatgaa 1216321 gggccgatca ttgaacagga tattgagcgt gtggaccacc gcgataatgc ggaagcgctg 1216381 aaaaacatcg gaagaacaat tgagcgcagc gtgcttgccc gtgctgtgaa atggcatttg 1216441 gaagaccgtg tcatcgttca tgaaaataaa acaatcgtct ttaactagac tgcaagaggc 1216501 ccgcgcaatg cgggctattt ttgatgacaa aaaaccttga caagtgtctt ttttctttgc 1216561 ataatataaa aaaatcattg agcgttgaag aggattagta agcagacctt tctgtgacag 1216621 agagcaaaat gaatcgctga aacattttgc cgcatgaaac ctgccgaacc tgccttggag 1216681 tcctaggggg aaaacctagg cgcataacct ggcgttacag gagagcggag cgtgcacaag 1216741 cgcgttcaat caaggtggta ccacggaaac ccatttcgtc cttatgaatc aggatgaaat 1216801 gggttttttt attgtagaag agccgcggag gagaataaat gaaaaaacaa agaatagtag 1216861 tgaaaatagg aagcagttcg ctcacgaata gcaaaggaag cattgatgag gcaaaaatca 1216921 gagagcatgt tcaggcgatt tccgtgttaa aaaaagcggg gcatgaaatg attctgatta 1216981 cctcgggtgc cgtagcggcg gggttttcca gcctcggtta tccatcccgt cccgttacca 1217041 tcaaaggaaa acaggcggcg gccgcggtcg gacaaacact gttaatgcag caatatatga 1217101 atcaatttaa acaatactca ctgactccgg gacaaatcct tttaacgaga aatgattttt 1217161 cgaaaagaga acggtatcga aacgcgtatg ctacgataat ggaattatta gagcggggcg 1217221 tcattccgat tatcaacgag aacgattcta catctgttga agaattgaca ttcggagata 1217281 atgatatgct ttctgcgtta gtcagcggat tgattcacgc ggaccagctc atgattctca 1217341 ctgacattaa cggactgtat gatgccaatc caaatgaaaa tcctgaggcg aaacgatttg 1217401 attatttgcc agagatcacg cctgaattgc ttggatatgc aggttcagct ggatcaaagg 1217461 tcggcaccgg cggaatgaaa tcaaagctgt tagccacaca aaccgcgctg tctctgggag 1217521 tgaaagtatt cattggaact ggcagcggag agcaaaaact tgcggacatt ttggacggca 1217581 ggggagacgg cacttatatc ggagacaaag aactatcttc ggttaacaac acaaggcagt 1217641 ggattcagtt ccactcgccg atatcgggag aaattatcat tgatgcgggt gccgaagagg 1217701 cgatgatcca taatggaagc agccttttgc ccgctggagt tgtgggcgtg aacggaagct 1217761 ttccgaaagg ggcggttgtg gaagtcaggg gaccgggcgg cgtgatcggc aaaggccaaa 1217821 ctcattactc ctccgaggag attatggagg ctaaaggcaa acgcagtgac gaacttgatt 1217881 ttgagaaaac gtttgaggtt attcatagga atgactgggt caatgtaaaa gactaggagg 1217941 cggaaaaatg agtgaagttt ctgtaaaagc gaagctggcg aaagaagcag cagccgaaat 1218001 gatcatgaaa acaacagccg agaaggatga ggcgctcagc ctcattgcaa acggactccg 1218061 caaagaactg gattttctct tggcggagaa tgcaaaagac attgtgaacg gaaaagagaa 1218121 tggtttaaca ccggacatca ttgaccgtct ctcattggat gagaaacgga tacgcgatat 1218181 cgcggacgcg gtggagctct taatcgactt agcggaccca atcggcgact ctcttgaaac 1218241 gattgaaaaa gaaaacggcc tgtttattga aaaaatccgt gtgccgctcg gtgtcgtagg 1218301 aatgatttat gaggcgaggc caaacgtcac agttgatgcg gctacccttt gcctgaagac 1218361 agggaacgcg gttgtgctgc ggggaagctc ctcagccatc cacagcaaca aagcgctcgt 1218421 cagtgtcatt tacagagcac ttgagcaatc agcgcttccg attcacgctg tgcagctgat 1218481 tgaggatacg agcagagaga cagcaaaaga gctctttacg ttaaatgatg gcttagacgt 1218541 attgattccg cgcggaggca agaaactgat tgatctcgtt gtgagagaat caacagttcc 1218601 tgtattagaa acgggagcag gaaactgcca catattcatt gacgaaacag ccaaaccgca 1218661 aatggcagaa aaggttgttg taaatgccaa aacgcagcgc ccttctgtat gcaacgcgat 1218721 tgaatcattg ctgattcaca aggcttgggc aagacagcac ggaaaagaat tgctggacca 1218781 gctggaaaac gcgggagttg aaattcgcgg tgatgaattg gtatgtgaac ttcatccttc 1218841 aagcaaacaa gcatcaaaag aagattggga aaccgaattt ttagcgcctg tcctcagcgt 1218901 aaagacggtt gaaaacgtcc aagaagctgt aaagcatatc caacaatacg gcaccaatca 1218961 ttctgaagcg attttaactg aaaatgacaa aaatgcggta tattttcaaa cggctgtcga 1219021 tgctgccgct gtctatcata acgcgtcaac ccgctttacc gacggctttg aattcggcta 1219081 cggagccgaa atcggcatca gcacgcaaaa gcttcatgca agaggaccga tggggcttcc 1219141 tgcactgact tctacaaaat acatcattaa aggaactggg caaatccgtg aatagcgggg 1219201 taatgttcaa tgaaaaagct tatctcatta cgagataagc ttttttatac gcgaaaaatt 1219261 gacatttcaa atttaattgt gtacaattta attgtataaa atatattggg ggaatgaaaa 1219321 atgagtcagc cattatttac cgcaactgtt tcagcggtag gaggaagaga aggaaaggtc 1219381 atttcatcag accgcgttct tgagcttgat gtcgcaatgc cggggacacc gagagccaag 1219441 aaattagaaa aagcgacaaa tccagagcag ctgtttgcag caggttatgc agcttgcttt 1219501 gacagcgccc tgcagcttgt cgcaagaaca gaacgggtaa aagtagagac agaggttaca 1219561 gcaaatgtta gcctgttaaa ggatgaagcg gaccagggct ataagctggg tgtgacgctg 1219621 caagtaaaag gagaaggagt cagtgcatca gaattggagg cgcttgtgaa aaaagcgcac 1219681 ggcgtctgcc cgtactcaaa agcaacctcc ggaaatattg atgtgacact tgaagttgct 1219741 gaataaataa aaagaggatg cctgtacaag gcatcctcaa tttttttgat gaagtgtttc 1219801 cagtaatgta tatagagcgg actttaactg tttgagatcc tccccagact gctttgagag 1219861 ccccagaatt gtccctggaa tgtcaaccgc tttttctttt aataacgctc cgtcctctgt 1219921 caggctgatc aacacggacc gctcatcctc ttcagatctt tttctcgtaa tcaaaccctg 1219981 ttgttccatt cgtttaagca tcggagtgag cgttcctgaa tctaaataca gctgttcgcc 1220041 catttttttg acagtaagcg tttcatgttc ccataacaaa agcaaagcca aatattgagg 1220101 gtatgttata ttcagcttat caagcagcgg cttgtattgc tttgtcatct cccgcgaact 1220161 cgcatatagc aaaaaacaaa gctgattctc caatttcata tgatcaaatt tattttccat 1220221 tttgttcacc aactcttttt tgtcattcga ttctattgta tctgaaaaac ctcacttttc 1220281 ctattctcgg caaacatagc atgtttaaaa agatcagaaa gggaaatata acaactagat 1220341 acaaataagg aggttgggaa atatggcact atttacagca aaagtaaccg cgcgaggcgg 1220401 acgagcagga catattacat cagatgacgg tgttcttgat tttgatattg tcatgccaaa 1220461 tgccaaaaaa gaaggacaaa ccggcacaaa tccggaacag ctctttgcgg cagggtatgc 1220521 tgcatgcttc ggcggcgcgc tcgaacacgt agccaaagag cagaatatcg aaattgattc 1220581 ggagattgaa gggcaggtca gcctcatgaa ggatgagagc gacggcgggt ttaaaatcgg 1220641 tgtcacactt gttgtgaaca cgaaagattt agatcgggaa aaggcacaag agcttgtcaa 1220701 cgccgctcat gaattctgtc cttactcaaa ggcaaccaga ggaaatgttg atgtaaaact 1220761 agaattaaaa taatgaccgg catcctgagg attctcagga tgttttttgg tgtcggacat 1220821 gcggggcggg cacagattta tgataaaact tcagagaagc gtttgaagca tgcctttaaa 1220881 ccaaaagtta cagatgaagc gggtggctgg cacggtgtct gccgtgctga attgcgcgta 1220941 tatgctgttt tgtatttgca cagggcatag cggctacttg gagaaataac aaggaccagg 1221001 ccgcgcatgc ctgatccttt taatattctt tcttattggc gaagttccgc catgcttgaa 1221061 acggggataa atgctctgtt agtgtcactt gataaaaggg gatcgttctt tcttcagcag 1221121 gtttatcaat ttctttataa atgaatgaat catcaaaccc ggcttcggca gcgtctgtgt 1221181 gctcagctgc atagaaaacg gctttaggcc gggcccagta gatggcgccc aagcacattg 1221241 ggcatggttc acagctcgta tacaaaatgc agtcatcaag ctggtaggct cctagcacct 1221301 tacaggcttt ccgaatagct gtgacttccg cgtgggcagt cggatcattg cttgttgtga 1221361 cgttgttctg tccctctgca ataatggctc cgtctttcac gataacggct ccaaaaggcc 1221421 cgccgattcc tgcattcact ccttcacatg cgagagtgac agcccgtttt aagaacgttt 1221481 catgattcat cccaatccct cctgtcaata gagtgttatt agtatagccg aaaagaatgc 1221541 aaagaacatt cttaaaaaag tgcaaaataa acaaagtatt tgggggattt gctaaataag 1221601 aaaccgattg tggctgtatt atagaaaaaa accatctgcc aaatgcagat ggttttttca 1221661 aattatacta gctgtgtctg ctgtgctctt gcctgttttg cggcttcaac catatttttc 1221721 aatgctgcaa ccgtttcttc ctgctgtctt gttttcaatc cgcagtctgg atttacccag 1221781 aagcggtcag tcggacagac ggcaagcgca tcaacgataa tattgtacat ttcttcagtt 1221841 gacggcacac gagggctgtg aatgtcatat acaccaaggc caagcccttt caaatacggg 1221901 tggtttttta agtaatctaa aaatcctccg tggcttctgc tatgttcgat tgtaatcaca 1221961 tcggcatcaa gatcattgat tgtatcaacg atatcttcga agttgctgta gcacatatgt 1222021 gtatgaattt gtgtctcgtt tttcacggaa gaagtggtta atctgaaagc ttctgccgcc 1222081 caagtcaaat actcatccca atcgcgggtt ttcaatggaa ggccttcacg cagcgctggt 1222141 tcatcgactt gaatgatttg aatgcctgcg tcttcaagcg ctttaacttc tttgcgaagg 1222201 gcaagcccga tttggaaggc gatttctttc ctcgagatgt cgtttcgagg gaaagaccag 1222261 tttaagattg taaccgggcc cgtcagcatt cctttcacat gcttggaagt caatgactgt 1222321 gcgtagactg tgtctttcac tgtcatcggt tcaataaatt caacatctcc gtaaatgact 1222381 ggcgggcgga cacagcgtga gccgtatgat tgaacccagg catatttagt gaaggcgaaa 1222441 ccggccagct tttcaccgaa gtattcgacc atgtctgtcc gttcaaattc gccgtgaaca 1222501 aggacatcaa gctccaattc ttcctgaata tcaatccatc tttttgtttc cgcattgata 1222561 aagttttgat actgttcatc ggaccactca gctttccgcc atttttggcg tgcgctccgc 1222621 acttcagcag actgcgggaa gctgccgatc gttgtcgtcg gcaaaagcgg aaggccgaga 1222681 gattcatttt gtagggctaa acgttcttca aacggaatcg ggcgcttgaa gtctttatca 1222741 gttaattgct caagctcttt cttttgttca gaattggcgc ctgttgcaaa ctgtttaagc 1222801 gcctggatat cagccttagc ctgctgaatc tcttcgctga tcgccgcttt tcctgatact 1222861 aagccttctt tcaaagctgt cagctcggcc agcttttctt ttgcgtagga taatccgttc 1222921 aataggtctt tttccaaatg ctcatcaggg tgtttcgcta ctggaacatg cagcaggctg 1222981 ctggaaggct gaatccacag ttcatcaact tttgcaatgc tgagaatatc aagaacggca 1223041 tcgagacgct cttcaaggtc cgctttccaa atgttgcgtc cgtcgataac gccggctgcc 1223101 agcactttat ctgtcgggaa gccatgtgtt ttaagctgtt ccaggtttct gcctttgtcg 1223161 tgaacgaaat caaggccaat tccctgaacc gggtaagaga tcagctcttc ataagcatca 1223221 acagaatcaa aatacgtctg caaaagcaca ttcaaggatg aaagctcact tgtaatgctt 1223281 tcaaataatt cttttgcgcc gcgtacatct tcactagagg cggtaacgag cgccggctca 1223341 tcgatttgaa cccattttac gccttcttct tcaagctctt tcaaaagctg tacatataat 1223401 ggcacaaggc gtttttggat cgcttttgct tcagacggtt catagccttt agcaagcgta 1223461 acgaacgtat aagggccgac aatcacaggc tttgtttcca caccgtattc ctgtttgatc 1223521 cggcgataat cttcgagttg tttgtttctt gtcagacgga actcaatgct ctcgtcatat 1223581 tccggaacga tgtaatggta atttgtatta aaccattttg tcatttcact agatacagcg 1223641 tctttgattc cgcgggcgat agcgaagtat gtatcggtag cgtcagtcaa atgtctgaac 1223701 cgtttcggga tccagttgaa gctgactgct gtgtcgagta catggtcata ctgtgtgaaa 1223761 tcagaaacag gcacaacatc aatctgctgg tcaatttgtg tttttactgc ggataaaaat 1223821 agttcgtcga tttgcttcaa aaacgtatct ttatcagtac tgcctttcca atacgcttca 1223881 agtgcttttt tccattcccg gttcagtccg attctcggaa atcctaaatt cgatgttttg 1223941 atggttgtca ttgtttctcc tcctttatat gtaaaacact ctctttcacc cgcggataca 1224001 ggctgctaag aggttttctc acaacaaaaa gcctctttcc catgagagaa agaggctttt 1224061 ctacgtaaaa cactgcctct ctcatctctc agacacaatc tgatggaatt agcaccgtgc 1224121 cttatgagac atcagtctcg gcgcgaaaag cagtgcgccc catttcacaa tggtattacg 1224181 gtcggttgct gttggggtca aaaggccaat ccctcgccca actctcgata agagaaaatg 1224241 ttattaattt tttgaaaagt tgaatcattt gttggtaatc ttaacagtaa ttcaaattca 1224301 ttgtcaacat agaatttgaa atttttattt acatgatgtg gtgtatatta tataagaaaa 1224361 ataatcttat agggtcaaca aatgtgattg ctctgctttt tctgcgagct catcaggagc 1224421 tgttaaatac aggaatccat tgcctgccag cgtttttgca atatcaagag gaagtgtcct 1224481 gcggattagc tgtgcgaaaa cctcagattc agaaagcttt ctttgaaatg attcttcttc 1224541 atagcttttg attaaagcaa gcgcaccgct gacatgaggg gcagccattg aagtgccggt 1224601 cagcttaccg tacttcttgt tgggaagggt ggataagatg ttttctcctg gtgccacaag 1224661 gtcaatctct ttattcgcgt tagaaaattc tgataattct cgcgctacag aaacagatcc 1224721 aactgcaatc acttcattat aagctgcggg gtaggaaagc tcttctgtgc gttcgtcgcc 1224781 gtcaccttca tttcccgctg cacaaacgac aagcactccg tttttcactg cgtttttcac 1224841 tgcttctttt agctctggca catcgcttgg ccctccaagg gacattgaga tgatgtcgac 1224901 tttctgttcc accgcgtagt tgatgccgtt aattatccat tcgtattgtc cgctgccgtt 1224961 ctcgccgcca agaaccttca caatcaatag gcttgcctca ggcgcgactc cggcaatgcc 1225021 tccgtttgaa tcattagctg caattgttcc ggcgacgtgt gtgccgtgtc cgttgtagtc 1225081 ggaaatcgca tcttccttgc cgccgtcgtc atccgtgaag ttctttccgc cgatgatttg 1225141 attttttaaa tcagggtggc ttgtgtcgca gcctgtgtct aatacagcaa ctttaatatt 1225201 tttgcctttt accccttttg cccacatttc tggcgcctta atcactttaa tgccctcagg 1225261 aagctcgttt acatccatga tctgctcatt cgtcacatac gggatcaagc ggatttcacc 1225321 attcataaaa aagccctcct tttttatgct tgcaagtgga ttcaagggtg ttgcctcata 1225381 ttatatgaaa aaagcaagcg ctcggacaga gccatttgaa gcattttgaa aaaataggat 1225441 acacaccaaa gaattagtaa tcttcaaaat attggatggc ttcaacatgt atgactggga 1225501 ttcaactgta agtcaagtta taatagtgtt ggggaaagga gcagtgtcat gaaactgaat 1225561 gaaaaattat atgcattttt ttcagagcat gtggaacaaa tggccgagga atggattgaa 1225621 acgatggagg aaagtgatcc gaattcgctt tacgccctac ataatgcaac agtaacggaa 1225681 gaattgaaag agcaggacag agaattttac cggcatctga attacatgta tgttttaccg 1225741 gaaaaacaat ttctcgaaga gtttcaagag tgggtcattg agctgaccaa cgatcaaaaa 1225801 catctcgaca caccggttca gtatgtcatt cgggagttta tgagaaacag gagattatat 1225861 acgaagtatt ttgagaagtt cgcagaagaa aatgaatcag cgtttgaacc gggagagaag 1225921 caaaaatggg cagatttgat tgtaaaagta tttgatttca ccatttatac attcgttgat 1225981 cacgctgaaa tgaatgccaa gcagcaatta aacgcccaaa gagaaatgat attggaatta 1226041 agctcacctg tcattaccct gagcaaatca acagctctgc tgccgcttgt cggtgacatt 1226101 gataccgaac gggcgaagtt tattctggaa aacacgcttc aagcttgtgc gaaaagacgt 1226161 gtggagcatc tgttaatcga tctgtcaggt gttgttgtgg tggatacgat ggtggcgcac 1226221 cagatcttta aattgattga ggcgcttaat ctgatcggtg tccggtcaac cctgtcagga 1226281 atcaggcctg aaattgcgca aactgctgta cagctgggga ttgacttttc gaatattact 1226341 attaaaacca accttgccca agcattaaac tatcatcaat aaaaaaatcc gctatctgtg 1226401 atagcggatt ttttatgatg cgaaacataa agatacgaga aaggatcccg cgaataataa 1226461 gaggacgagg caaaagaaca cccagtcgcg ccggttcacg ctcaatgtcc tgtagtatgt 1226521 ccggtttctg cttcctgtaa atcctttcga ttccatcgca agcgctgtcc gttccgcttt 1226581 tctgatggcg cttgccaata gcggtatggt atatcgtttt aacgcactga ttttattaat 1226641 gatgccgctc tccgccgctc ctcctctgat tttatgagcc tgctgaatca gctggacctc 1226701 atcctttaac agcggaagaa agcgaaagcc tgcaatgaca ccgtacgcga gctttggtga 1226761 gagcctgcac tgctggacaa ggctcagcat aaatagaatc ggatcggttg taaaaacaaa 1226821 catcatcgat aaggcggaaa agcataaaat acgaaacccg agagagatgc cgacagacac 1226881 attatcgctg ttaatggaga tagggcctgc ttgaaacaaa aaattatccg gtgttgtcgg 1226941 cacttttcca aaaactgcgg ctgtccacac gcatccgaat gctaaaatca aaaacggaat 1227001 cgtaaacaac aaccattttt tcaatgggat tccggccgcc agtaaaacgc ccgcaacgat 1227061 gatgatataa aaacatgccg gagtgtaagg gttgtaaata aacgacagca tgacgacaca 1227121 acaaaaaacc gccgccgctt tcacagtcgg attaatgaga tgtaacggtt gcttcatcac 1227181 gcacctcctc ttgaaatgcc atccattcat atagaagggg aagggtgagc tttgcttttt 1227241 gaacaagccc tgtttcttga gaaaacaact gcgctggaga tccgtcaaag gccaggcctg 1227301 tatcgtgaag cacaagcacg ctgtcagcat acgaagagac tagctccata tcgtgtgtaa 1227361 tcataaggac agcagttccc tctgccttga tacgttgaat catttccatg cattcagccg 1227421 ccgtgcgggc atcctggcca aaggttggtt cgtctaataa taaaaccttt acgtcatgca 1227481 tgagcatagt agctacgctc agtcgccgtt tttgcccttg gctgatcgca aacggatgat 1227541 gatcagccaa atgcgcaaga ccaaaacgct gcagcaggtg ttgcgctttt ttctcagttt 1227601 cagcatttgc tttctggccg aacagaagct cgtcatacac cgtatcggtg acgaattgat 1227661 gctcagggtt ttgaaaaaca aatcccatcc gtttacgcaa ttctttttct ttatatttct 1227721 gcagcggctg atcatagaga aggattttgc cgctttgcgg tttcatgaga ctggccagaa 1227781 ctgataggag cgtcgatttt ccagttccgt tcggaccgac aagcgccgtt aaagagcctt 1227841 cgcgcaacga aaagctgatg tctttgaaaa tcgcctgctg tcctctcgcg aacgaaaggc 1227901 tgctgacttc aagcacactc tccccagaag gggctttctt ctttttgaca tgcccggcag 1227961 gaataggctc tttgaacagc atctcttttg ataaagtaaa cggcatactc agcttttcct 1228021 gcagatgaca gacctttgga atggcgatgc ccaatttctt tagtgtctcc gcttcatgct 1228081 gaaatagatt tttcgtcagg ccatccagtg cctttttgcc tgatttgtcg agtacgatcg 1228141 ttctctcaat ccaaggcgcc cattcatcaa gctggtgctc aatgacgagg aggctgaaac 1228201 ctttttcccg ctgaagatcc ttcatcagat gaacgaactc ccgagctgag aaagggtcta 1228261 aaagagaggt cggctcatct aaaataataa gctcaggctc catcgccaaa atacaggcga 1228321 gagccacttt ctgcttttgt cctcctgaaa gggttgagat cattttttct tttaaatggg 1228381 taatgcgtaa tttttctaat acggcgttga ttttctctgt catttcttct tttggaattt 1228441 gcagattttc cagcccgaac gctatttcgt cctccaccgt cagcatgcag aactgctgat 1228501 caggatcctg aaaaacgacc ccggcatgct gagtaatcgt ttcggaggtt tcagcatctg 1228561 tgaccggctt ttgaaataga aatacatgtc cggactgaat gccgtcgcaa gcctccggat 1228621 atagaccgtt taaacaaagg gcgagcgagc ttttaccgca tccgctcggt cctaataata 1228681 aaacacattc tcctttttga agctcaaacg aaatgtcttg aaaaaccggt ttctcgtctt 1228741 cttcataaga gaagctgagc tgctcaaccg tcagaagctc atcaaaggct tgcatgttct 1228801 gacgcccgct tccgtttctt tttcagttcc tttccgagtg ccattccgtt taacacacct 1228861 gtataagcga gagagtcgct gacagctttt ccgagaagcc ccgccaaaag cgcgccggaa 1228921 atgaggcgga tcacaagcat aatgagcaga taacctggtg aataggctgc atagccagaa 1228981 acaaagagat catagataaa gctggctact gaagacccca taccggccag cataaggaca 1229041 gggagagagt atgctttcca gcgtgttgca agaaatacag cctcagcccc gagcccttga 1229101 acaatgccaa tgacgatgac catcgggcca gacggatttc ccagcaggca ctcaacgaga 1229161 gcggcaatga tttcagaaac gagcgccgca cccggttttc gaatcatgta cgcggcgatc 1229221 acagaaacga taaaccaaat gccgtaaatt ggttcatagg cgattggccc aaacatacct 1229281 gcaagtacgt ttccgaaatg tgtaaataat aaataaacaa cggcaaatac gatactgata 1229341 acggacatga tgacaatttc ttttactttc cagcttttca tgttatccct gctttctgtt 1229401 ttttcttgat ggactgttag ccgaaagatt cacagtcatg gtgatgtggt ttgtttgctg 1229461 ctcagccatg cggaaaacgg cctccaatgt gctgaatacg tcatgcgcat ccccgtcaag 1229521 ctcgctcgcg taatggacac cctgtacgaa agtgccttgg gcttttgcaa tgtcgacagc 1229581 ctccataatc aatcccatat aatccggctc attcattgga taaagggcaa attggcacgg 1229641 cgcttccgcc ttcaagcctc ggacagcatc ttcattgaca cgcttatcac ctttggaaag 1229701 atatgtatcc ccctgtgtgt cacccgggca tccaatggaa aacgtgccgt tcatgacgat 1229761 gtgttgttcg ctgtttgctg catgaaggta aatggctttt gcagcatcga atacatgatc 1229821 aatcgatccg cgtaacaccg tgctgatatg gtcggttttc gtccaaacct tggatgtatc 1229881 tgtttttttc agcgcagact tgatcacact gataaaatca tccgtcatcg gatataaaga 1229941 gaagcgaaaa ccggcgattc tgcttgtacc gcaaatatgc tccatttctc cgacctcctg 1230001 tttttttggt aaaataaaaa actgcatatc ctaagggaat atgcagtcat agatcgatta 1230061 agcgcacaaa aaaatacacc attcggtcaa cctgcacttc cccacgctgg tattatccag 1230121 atcgggtcat aagggatcaa agcgcgtttc ttccgcgctt tatctcagcc aaaacagcac 1230181 ccctagtgct ttccgtatac aattttttat tttgacatca taatagatga taagaatcat 1230241 tttgtaaaca acgaaatcat ttttttcata tagggacggg agaggatggt caaatttgga 1230301 aaaaggacac atattaattg tggaagatga agaaaaaatc gccagggttc ttcagcttga 1230361 attggaatat gaaggataca gcgtcacgat caaacacaat ggcacagaag gtcttgatgc 1230421 ggcagcggaa ggcgggtatt ccttggtgct tcttgatgtc atgcttccgg ggcttagcgg 1230481 actggaagtg ctgcgccgct tgagaaaaac ggattcgcag acaccggtca tattattaac 1230541 ggcgcgagac agtattcctg ataaggtaac aggtctggac atcggtgcaa atgactatgt 1230601 caccaagccg tttgaaatcg aggaattgct tgcgagaatc agggcggcgc tgcggcaaaa 1230661 tggaacaaaa actgaagata tcggcacctt tcttacatat gacgatttgc gggtgaacga 1230721 aaaaacccgt gaagtgagac gcggagacaa agaggtggaa ttaacgccgc gggaatttga 1230781 tctgctcgtc tatatgctaa agcatccgca gcaagtgctg acacgggagc aaattctaag 1230841 ctcagtatgg ggatttgatt atatcggtga tacaaatgtc gtggacgtct acataagata 1230901 catcagaaaa aaactggact atccttacga aaaacagctg atccatacga ttcgcggggt 1230961 cggctatgcc attaaggggt aaacgatgaa gctgaagacc aagattcatc tatacacttc 1231021 gatatcactg ttgattttat taattttggt tcataccgca gtatatctca ttttttcgtc 1231081 tgcgctgaca tcaaaggatg cggcccggct tgctgatgag acggataaca ttgccgaagc 1231141 gctgcgtgcc gctgaaacag aaggagtggc tttgcaggat atgctgcagg cctatcttcc 1231201 ggcaaatggc atggtgcgtg tagtgaatgg tgatcaaaaa gccgttatga cgatcacaaa 1231261 agaaaaagcc tataaagatt ttcctctctc ttttcatagc ggcgaaacgg cagatgtgag 1231321 gaaacctgac ggcaagctgt ttgccgaggc tgctgttccg gtgatttgga ccgatggaca 1231381 agtcgtgtct cttcagctgg ttgaaagact ggagaacaca gaagagagtc tgtttctgct 1231441 gaaaatcatc ttaatcgctg caagtgctgc tgtctgcatt gcttcttttt ttgcaggcag 1231501 cttgctagcc cgccgaatca tcaatccgat cagacgatta atgatcacaa tgaaagacat 1231561 acagcgagac aaagaattta aaacgatttc tttagaagga cagtccaacg atgaattgta 1231621 tcaaatgggg ctgacattta atgaaatggc aatgatgctg aaggagcact atgataaaca 1231681 gcagcaattt gttcaagatg cttcacacga attgaaaacc ccgctcacta ttatagaaag 1231741 ctacagcagc ctgatgaagc ggtggggtgc aaaaaagccg gaggtgcttg aggagtcgat 1231801 agaagccatt cactcagaag cggtgcatat gaaaaaactg accaatcagc ttttggcgct 1231861 ggccaaaagc catcaaggac tcgaggttga tctgaaaaca atcgatctga ttaaagcggc 1231921 gcgcgcggtt atgcaaacgc tccagtccgt ttatcagcgt gacatattgc ttgaaacaga 1231981 taaagagagc ctgcttgtaa aggcagatga agaacgcatc aagcagctgt tgaccatttt 1232041 gcttgataat gcaataaagt atagtgaaaa gcctattgag atgtcagccg gaacgaggaa 1232101 tggacggcca tttctatcag tgagggatga aggcatcgga atacctgagg agcatatccc 1232161 gcatttgttc gaacggttct accgggcaga tgaggcacga aacagaaaaa caggcggaac 1232221 aggtttaggc ctttccattg ccaagcaaat cgctgatgag catggcattg agctgtctgt 1232281 caaaagcaag ccgggacaag gaacagctgt caccatgcaa ttcagcgaac agaatggggg 1232341 aggccgatga ctaaaacaat aaaaacagta tcttttgctg cagcagccat tttagttgtc 1232401 atcatctgta cgtttctcat cattcggcaa acccatgaga acgtattgtc aaaggagact 1232461 gtcgtaaaaa aagtcgaagc ctcttatgaa ggcaaggtca cgaaagcaac acaatcaaag 1232521 gataaaaaaa catatgatat aacccttgaa aatccaaagg gaacttactt tgtaaaagca 1232581 gacgcaatat cggctgacat tctttcaatg aatagagtaa aagcagtgaa tccatctgcc 1232641 atgacagaaa aagaagccga gcatctcgcg cttgagcggg tgccgggaac ggtcaaaaaa 1232701 caaacacggc aaagtcaagt tgccacttat accatacaaa aagaagacgg gaaaacatac 1232761 gaagtgaagg tagacatgca ggcaaaaaca gtcttgtctg ccgatcaaat cagcagcaaa 1232821 gatcaacaaa aaacgccgat tacgaaaaaa gaagccaaaa caattgcaga gcgaaaaacg 1232881 ggcggaacag cggatgacgc agatctcgaa gaaagtgagg gcactctcat ctttgaagta 1232941 gacgttgatc ttcctgataa taaggaagcg acagtgaaaa tcaatgccta cacaggaaag 1233001 gtagctaaca ttgtgtatga agactgacgg tttctcatca aattctcatc ttgctctcgt 1233061 tttcctttca tgttgagtat gtaaactgta ctcatacaaa acaaaggagg gctcacaaat 1233121 gctcaagaaa aaatggatgg tcggtctttt agcagggtgc ctagcggccg gaggattcag 1233181 ctacaacgcg tttgccacag aaaacaatga aaacagacag gcttcttcta agacggatgc 1233241 actcactgaa caagaagcag aagcaattgc taaaacagtt gttgacggca cagtagaaga 1233301 cattgacaga gacctttaca acggcaaaga agtctatgaa gtggagattg aaaaagaagg 1233361 tgaagactac gacgtttatg tagatattca tacaaaacaa gcgcttaatg acccgttaaa 1233421 ggagaaagca gaacaagtcg ccataaccaa agaagaagct gaagaaattg ctttaaagca 1233481 aacaggtgga accgtaacag aaagtaagct tgacgaagat gacggtgctt acatctatga 1233541 aatggaaatc caaacgaagc aaggaactga gacagaattt gaaatttccg caaaagatgg 1233601 acgcattatc aaacaggaga tagatgacta atcaaaaccc ccgctgcagc gggggttttt 1233661 catgataaga aaccttcttt tggacaatct aagtagaaaa ggaggcgaaa cgcatggaaa 1233721 agaaagagga gcaatacatc aatcaggctg aatatgtccc tcatccgacg aaggaaggag 1233781 agtatgcctt atttcttcat gaaacgtatc atttgctttc tgaagatgac gagacacaaa 1233841 caacagaata agggcttagg cccttgtttt gttccgtaat tgtgatgtaa gcgcatttat 1233901 tacttttttg agttgacata gcttgttttt ttctgtaatc tcagtgtgtc aattcaatta 1233961 ggaacttcgt taggtgaggc tcctgtatgg agatacgctg ctgcccaaaa atgtccaaag 1234021 acgccaatgg gtcaacagaa atcatcgaca taaggtgatt tttaatgcag ctggatgctt 1234081 gtcctatgcc atacagtgct aaagctctac gattgaaggc gcccgcacgc tttttttgcc 1234141 gtgcttcttt caccttcaat cccgaaggct ttttttatgc ctttaaaacg aaaccaatca 1234201 aaggaggtgc ggagtatgga ttctccccat tcgagtcaat ctgaagaagt acccatatac 1234261 tatgacagca agacaattga ttacacgatg aggagacgaa ctgccgcacc ttctggcgag 1234321 gccggcacgt ctccgtagag gaggtacgag tcccgatggt tcaaaacatg acctatgacg 1234381 aactcatttt acgcatcatt attttactgc gagacgggaa aatcagggat tttagaagtg 1234441 ttattgatga gcttcagccc tatgacatgg catttatttt taaagaaatg ccggaaaaac 1234501 atcgcgcccg ctatttatct tatttaactg tagacgatat cactgatatg atcggggagc 1234561 tggaacgcga atttcagctt gtcgtcttaa ataaagtcgg aaaaacaaaa gcaacactgg 1234621 cgatgaacaa aatggacaac gatgacctcg ctcaattgct tgaagaaatg gacgaagaac 1234681 tgaaggaaca gcttttatcc agcatggaag cgtcagaatc aaaagctgta cagctcttga 1234741 tgaattaccc ggctgattca gcgggacgca tgatgacaaa ccggtatgtg tggatccctc 1234801 agcattacac ggtaaaagac gcggtcgtca aactgaaaag cttcgctgaa atagctgaat 1234861 cgatcaacta cttatatgtt attaatgaaa gcaaacagct ggttggggtt ctttcctacc 1234921 gcgatttgat tctgggtgaa cctgaagaaa aggtgcagga tttaatgttt acccgcgtca 1234981 tatcagcaga tgctcttcag gaccaggaag aagttgcccg cctgatagaa cgttacgatt 1235041 ttttggcaat accggttgta gaagaaaaca acgtgcttgt cggcattgtg acggttgatg 1235101 atattatcga cgttgttatt cgggaagctg atgaggatta cgaaaaattt gccgcttccg 1235161 gtaaagacat cacctttgac acaaaagctt acgtggcggc ataccggcgt ctgccatggc 1235221 tgattttact cttatttatc ggactgattt caggaagcat tatcagctat tttgaagacg 1235281 cgctgaagca ggttgtcgcg cttgcgtttt tcatgccgat ggtgtcaggg atgacaggaa 1235341 atacgggaac acaatctctt gcggttgtca tcagaggttt gtctaaagaa gaaatgaaca 1235401 aaaaaacgat tgtgcgcctg atcttccggg agttcagaac aagcattttt atcggagcgg 1235461 tttgttctgt gctgattgcg attgtttcta tcatatggca ggggaatgcg cttttgggat 1235521 ttgttgtcgc ctcttcactg ttcttaacct taatcatcgg cacgatgtca ggaacgatta 1235581 tccctattat tttgcacaaa ctgaaagtag acccggcgat tgcttctgga ccgctgatta 1235641 caacgttaaa cgatatttta tctttattaa tctactttgg cattgccact gcattcattc 1235701 actcattata aacgtaaaaa gtccgtctca actgcgagcc ggacttttat tatttaacgg 1235761 tttttgtacc gaaagtgagc attaagctgc ccctccagca tttttttccg cacttgcgga 1235821 tcgtttttta acatctgttc ttttttgcgc atatccttta aaatctctgc cgtctgtacg 1235881 ccgtcttcac gcttattggc gatatccatc agccgctcca catcggcaaa ggagtatttt 1235941 cttgtccccc ttgaagaacg ctgcgggtaa atgagctttc gttcctcata atacctgatc 1236001 tgtcttacgg acaatcctgt caattcactc acaattccga ttgaaatcac ttttttgtct 1236061 ttataagaat gatcttctgt ggtcattttt ccacccctgg atgtcttttg ataatagtat 1236121 ataaaaaaca aagagaaaaa acctgacgct tgtcatattt tctaacatca aatagaagat 1236181 ttttgaaaaa atacggaaga aaaattaaca agaataatgc gtaacaccca agcgcgtttt 1236241 atcctttatg taacgaatca aacgaggagg aaggataatc atggaggaag aaaaagcagt 1236301 ctcactggca aaagaaatta tagagttgga tatcaagcgt gatgaaatgc tggagacgtt 1236361 tatgcagctt gccggagaac aggcttttca attattaaga tcggttcaaa acggacaata 1236421 ccgaaaatct tcgtaaacat aaattcttta cattagattc ataccacgtt catttaaaaa 1236481 gagtatcttt tgtataggat acctcaaaat gaaggaggac gctatgagta atttattgaa 1236541 atccgcttta gaaaaagaac gacgccatta ttctgaaaaa ctctatcaga taggggttta 1236601 taataaagag gtcatgaaca aaatgacgat ttctgagctt cggaaagaat acgcttattt 1236661 ctttcgaagc attacaaatc ataaaaatta tccttataca agataatgta taaggatttt 1236721 tttgctttta gaaggaattt ctcgaattat agcgaatacg tatagtaagg gactgaactc 1236781 ttattatatg taagggtttt cattattttt ttataaaaat cctatatacg aggtagatat 1236841 gatgagatta tcgtttaacg aagaagaagt tgagcgtgcg atgaatttgt acagagtttt 1236901 tgcaagggct ttcaaaagtg tgtccgaaca tagtatccgt gatagcaaag agcacggttt 1236961 taatcccact gaatttgctg tactggaact cctgtacaca agaggcccgc aaaaattaca 1237021 gcaaattggg tcgagacttc tgcttgtaag cggaaacgtc acatatgtta ttgacaaact 1237081 agaaagaaac gggtttttag taagggagca ggacccgaaa gataaacgct ctgtttacgc 1237141 acatttaact gacaagggaa atgagtattt ggataaaatt tatccgattc atgcactgcg 1237201 tattgcgaga gcgttttcag gtctttcgcc tgatgaacag gaccagctga tcgtcctgct 1237261 caagaaagca ggcatacaca gccagcattt gctgtttcgt taactattct acactctcta 1237321 tttcaggaga gtgttttttt gtttccatat gattcttttt aaaacatctt taatcttcct 1237381 atcagacatt tcgccaaggt atccattgac gtgtttttta tactccttca tctgttcgtt 1237441 cgattgaaaa aatgccgcga tatactcttc tgctttctgc atgtcccagt ttctcatatc 1237501 tgtgacgagt ttcctttcat gtagaaggtt taaattcatt tcctcctgtc ccggcagtgc 1237561 atgataaata aataccggaa gccgtttctg taagcattca ctgatggtca cgcctccggg 1237621 tttagtcatg atgcctgtcg cctgttcgta caaacggttc atctctgctt tgctgtgaag 1237681 gtaaggaatc gcctcaatca aggggtggtg taaacttttg acataggagt agagcttttc 1237741 gtttctgccg cataatattt tgtataagat ctttccgcct ggcgacagtt cctgcaccca 1237801 ttttaaaatc ccaccgaccc ccatactgcc ccctgtgatg atgatggtat atggcgggtg 1237861 gtgctgcaag gtatctgctg attccatttc aaaattttgg tgaactggaa tgccggtcaa 1237921 gtatatgttg ttctgatcga taccctctga tattagctgc ttctttactt ccgtgctcgg 1237981 aacaaaatgg taatcaatgt tcttccgtcc ccataattga ttcacgaaaa aatcagtgta 1238041 tacattcaca accgtcagat tcggatattc aggctttagt cggttcagca gataagaagg 1238101 cagcgcatgt gtgcagaagg cgatatcagg ctgtttttct tggaggatgt gcctcatttg 1238161 ctgtgtgaac agccattcgt acatgaaata gcgtttgtca tgctgaaatt ctccgcaggc 1238221 gaggagcctg taaatgccgc tgtacgtttt cgggaaatat tgaatccatt ttaaataagc 1238281 cacggaggac aatttttcta accgcctata cgaatgtgaa aagatatcaa tcttttcagc 1238341 tgccagccct tgagactcta attcagcctg caatgcatca gccacatgat gatggccggt 1238401 ggaaatgctt aaaaaaggaa aaatgagaat gtttttcatg acagtcctcc taaaaaaata 1238461 tggcaactat attttgagga gaacgttcac aaaatataag ggtgtttttg atcataagga 1238521 aggtgaaaag atgaaaactt gtttcctttc catatggaga gtggttgatc cgatttattt 1238581 ctttttttca aggctaagct tgattgacaa cgatcaaaaa agcgtttttc gagtcaggct 1238641 gacgaagtac aaaggacatc atgtcgtgct tagcgacgga acgcatataa gaaaaaatga 1238701 tgtgctcgtt aaaatccacc tgcataacat aaagctgatc agggagctgc aaagcattga 1238761 gagcgcagtc agaaagggaa tcattattta tcagaaagta tatcaatcga tgccgcttct 1238821 tcttgactat atcaacaatc ataaaaaaag cgagaaaatc aaaggaatca ttgggattac 1238881 aatgcttgac aaaggtgtgg aaaggctcgg ctttgatgtg atcaccccgg tgaacccttt 1238941 ttacagatgc tttaaaaaag tgtctcatgt gccgatttta tatttgactt caaagcctgt 1239001 gagcttgcgg catttaccga attcatccta tttgtttatc tcaaaagaaa agctgcagaa 1239061 aacctatcaa aaaaaagact gatgcctcgg tcagcacagt cttttttgat taaatctgat 1239121 gaaatgtcac ttcagggcgg cttccgacac ggatatttac gccggtttgt cccaagccct 1239181 cgctgatata aaatggttta tcgtgatgat aatgaaggcc tttaatcatg ttcattcgca 1239241 cgagctttcc cattttcacc aaatgatacg gttttggcca gtgaatttgc ccgccgtgaa 1239301 aatgccctga cagcaggtaa tcataatgaa catctttcat atccagaata atatttgggt 1239361 catgtgttaa gacaagatga tagccatttt ccagactttg ataagagccg gtgatattac 1239421 tccgattcgt actgtaatca tcaatgccga taatattgac tggtcctgca gccgtctcga 1239481 ttcgaacatg ttcattttgc agcgtgatac agccgttttc ctctaaaact cgcttcaatc 1239541 tctgaaagtc ctcttctttc aatacataat cgtggttacc gaacaccgcg tacattccat 1239601 atgcaggctt tagcttttgc aaggcgttca agtaacctgc cagtttcgga atattacgtt 1239661 tccgatcaag aaaatccccg gtaagagcaa tgatgtccac aggctgatct tttgttaaat 1239721 gatacagctc ctcaggtgag actgaaatgt tttccaagtg aagatcagat aaatgaagga 1239781 tatttaattt ttttctggct ggaaggccgt ctttttggtc gattgaaatg gtgttgactt 1239841 tcacatcttt tgtattgcgg ttcgctttat atagaaatgg cacaaatacg agtatggcca 1239901 atgaaagtaa gattgtaaac aaaatatatc ccctcccttc tatcagtata gtaagtgatc 1239961 aagccctatg gatagcggga attaatgggt agagacaggt tgaaaaacgg attgtcatat 1240021 gatgaatgat ttggaaggga aaagggataa taaattttga cacatgaggc agaacatgcc 1240081 gacggagtca gaataacaaa tggatgtgta agcaatgtta cgattgatga gacaacaaaa 1240141 aaaagaaaca tattatctct ggatcgcatt atttcttctt ttattgtatg tatccccgct 1240201 ttttatttta aaggaagatg cccatatccg ggtccacgat aatttagatt ccaacatcgc 1240261 ttggtacaag gttctggccg atagcggaga aatcgtcggc aaggttgacg ctgccattcc 1240321 gcaaatcatt aacgggctgc cccgggatgc ctttggcacc gagtggagcg gaattgtttg 1240381 gctccatgct ttcttttctt ccatgaccgc ctatgcaata agccagacgg ttacaagagt 1240441 tgtcgctttt tttggaatgt atgtgctgct gaagaaacat ataatcccgg aaccaaaagc 1240501 ggctttcatc cgaattggcg tatcgcttgc atttgcctta acaccgttct ggccttcggg 1240561 aatgctgagt acgcttgggt accctttggc actgtgggct tttttaaata tccgaaaagg 1240621 ggatatctca tggagagagt ggctgacgct gggcttgctc cctctatact caagctttgt 1240681 tctaggcttc ttctttttcc tggcagggat ggcgtgtttt tggctgtatg atgccattac 1240741 aaaaagaaga tggaatttga tgttcttagg cagtattgca tttatgacga gtatctatct 1240801 tttcgttgaa tatcggcttg tctattcgat gctgtttgag cacgcaccga tgcatcgtat 1240861 cgaatttatc tcatctaggc atgacgtttg gcattctctt cgactatcca taaaaaactt 1240921 tgtctatggc cataatcatg tgatgaccgt tcataccgtt gtcatccttc cgatcctgat 1240981 ggtcgtattt gctgctctgc tgttcaaacg aaatcggaca aagccagaaa atgtttatct 1241041 gtttttatgt gtgcttaatt acgggttgtc attatggtat gcgttttggt tcaacaaaat 1241101 ttgggctgtt ccaaagcaga aatttgcttt tttagcagaa tttaattttg cccgttttca 1241161 ttttcttcgg ccgcttgtta tatacgtgag ctttgcgctt gctttatatc tcatttggcg 1241221 gatggggaaa ggatggaaat ggcttgtgta cgccgcagtc gctgcacagc tgatggtgtt 1241281 ggcgcctttt aatgaagaat atacgtatgg tgttcattac aacgcgccga cattcaggga 1241341 gttttatgca tcagagcaat tcaaagagat taaggaatat atcggacgtc cgcaagattc 1241401 gtatagggtg gcgagcatcg gactgcatcc gtctatcgcc caatataacg ggttttatac 1241461 gttagatacg tataacaatc tgtatccgct ctcatataaa tatgaattta gaaaaatcat 1241521 cgaaaaagag ctggaaaaaa attctcggct gaaacaatac tttgatgaat ggggcagccg 1241581 ctgctacctt tttgtcgatg aactcggtaa acgatatgat ttcaaaaaga actcgaagaa 1241641 aacgatcaac aaccttcaat taaatacaga tgtatttaaa aaaatgggtg gacggtacat 1241701 tttttcttca gttccgatca tgaatgctga acaaaaccat ctcgcgctcg taaagacgtt 1241761 tgaccataaa gattccgcct ggcgcattta tttatatgaa acaagataag gaggatatcg 1241821 attgaaacag tcacagccag tattaaccat cgtcgtcccg tgtttcaatg aagaggaagt 1241881 gtttcaagaa acaagccatc agctgacaga ggttgtagat gatttaattg aagaaaaatt 1241941 aattgctgaa gacagtaaaa ttctgtttgt cgatgatggc agcaaagacc gcacttgggc 1242001 tttgattgct atggagagca taagaaacaa gaaggttacc ggcttaaaat tagcctgcaa 1242061 tgtcggccac caaaaagcgc ttttagccgg attgcataaa gcgaagaata ggtcagactg 1242121 cgtcatttcg atcgatgctg atcttcagga cgacatctct gtgatccggg attttatgct 1242181 gaaatatcat gagggctgcg agatcgttta cggtgtacgc cggagcagaa aaaccgatac 1242241 ctttttcaag cgcacgaccg cgttagggtt ttatcgtctc atgaataaac ttgggattaa 1242301 attaatttat aatcatgctg attttcgttt aatgaataaa aggtcccttg aagagcttga 1242361 gcgttatccg gaagcgaatc tgtttttaag aggtattgtc cccatgatcg gctttaaatc 1242421 ggccgaagtt ttgtatgacc gcaaggaacg ctttgccggc aaaacgaaat atccgctgaa 1242481 aaagatgcta tccttcgctt ttaacgggat tacttcattc agtgtcgcac caattcgatt 1242541 ctttacgctt ttagggtttg ttttgttttt cctcagcgct gtggcaggga ttggcgcgtt 1242601 tattcaaaag ctgctcggcc atacgaatgc aggctgggcg tctcttatca tatccatttg 1242661 gtttttgggc gggctgcaat tgatgggaat tggaatcatc ggagagtata ttggaacgat 1242721 tttttctgaa gtgaaaagac ggccgaaata cgcgattgat attgatttgt ataatgaaca 1242781 gctgagcccg cttcagcgcc aggaaaaaga gcggttagaa aaaaagtaca gttaaacacg 1242841 gaaagagctg acttcattag tcagctcttt ttcttcaact gatgcaatat agcgctaagc 1242901 ggttcgtctt gcgggttgcg gtaaaaatca aaaaatgggc agccctgctt cttaattcga 1242961 tcgatgaccg tatcaattgt aaacagagcg ggtgttaaag atgattgcac ctcatgccag 1243021 tagagcgggg ctgcaacagt cccaagctca tttcctctcg ttgaataggg acagataatc 1243081 gtttttcctt ctgcatgctg caaataatca agatacaatt tgcagtgtct gtttttaatc 1243141 aagcgttcag tggtaaagag ctcgggaaat gcattggtgc agtactctgc gatcagctgc 1243201 gtaaattggc gtgtttcttc atacgtaaat gcctcgggag acaagggaat ataaagctgg 1243261 atgcctttgt tgccggacag cttcgggtac gatgtgatgc caaaggaatc caacagccgc 1243321 ttcagttcat ttgcggcctg cacggccata agaaagtcat ctcgcgaagg cgggtctaaa 1243381 tcaatgacaa tctcagccgg acgcctgctt ttaatggttt gaaaaggaac gtgaaactcc 1243441 aaagcaagct ggttgcaaag ccatagcaat gtagacatat cctcacagac aatatgttca 1243501 tggcttccat catagaaaga ctgaacaaaa tccggcgcat agtccggctt gtttttttgg 1243561 aaaaatgatt cgctcctaga tccatgcgga tagcggatga cggtgacagc ccggtttttc 1243621 agaaatggga gcaggtagtc actgacttca atcatatact gaataaaatc ttcttttgtt 1243681 tttttattct tttcaaatat gattttatcc aggcttgtga actggagctt tgggtgaacc 1243741 ggtttggagt gtcgtatgac ttgcgcatac gtgcattcgg tccagtccat ttggaattcg 1243801 aaaccgataa acgatacctc tcttaatgtg ccttggagaa ttgttaagta ttgaacagct 1243861 gcacaaatcg aaggttcaag cgtaaattcg cctgagggtg tttgatgtcc gtgctgttcc 1243921 ataatctcgc gtatagcgct tttttcctca tcacgcattc cgtgcgagac agaggcaatc 1243981 ggtgtcatta ttccgttttt taacaccgat accgtcagaa acccgttgtt agggttgaac 1244041 cctgttatgc aaacataagc ttgtttaaag tttttatatt tgagccaatc ggacgaccgc 1244101 ttcttttcaa gccatttgct gtttgttttc ttcgctacaa ttccttctcc gtcatatttt 1244161 attaccatct cccagagttg atcaaaatga tcataacagg gaatggattg aatggtttct 1244221 tttgcgtaag gatctggaga tgcaggaagc tttgctgcgg atatgagttc acgcagcgat 1244281 tttttgcggt ccaaatacga aagaagcgtt acatcttctc cgcttcgctc taacaaatca 1244341 aaggcgagaa agcagcacgg ccgcgcgttt gccgattcct gaatcttgtc tggccttttc 1244401 aaacgccccc gcacttgaag gtgttcaaaa tctgcacgac agggattcac caaacatacg 1244461 atttcaccgt caagtgtcag cggaagctct ttttctaggt gctgaaaggc agttttggcg 1244521 aattgtgtga tttcagggaa ggtgctgctg agctccacac catttctgct ggttaaggtc 1244581 acacctgaag aatggatgcg gagaatacag cggtacccat catattttac ttcgtaacgc 1244641 cattctgctc cgattggcgg tgacgaagtt aagaccggct gcatggtaaa cgccatgcgc 1244701 tatgatgtgc cggaggcttt ttttctagtt gttttttgtt ttttatctcc ggctcctttc 1244761 ggttcagcgg cttgtgcagg tgcggcagcc ggtgtctccc ggttcggcct tctggttctg 1244821 tcgatgctgg cttgcagagc gcttaccagg tcaatgacat cttcacgagg tggcgcttta 1244881 tcaggagtga cagccgtttc tttattttct agcttgtcgt tgactctttg cagcagcgcc 1244941 tgtcggtacg tgtcttcata tttctcaggc tcaaacttag cagtcagttc atctattaat 1245001 gtgatagcag tttgcagttc cttatcgttt acattcgatt gatcaggtac acctgggact 1245061 tgagcggcgc ttctgacctc atcgggataa tggatagact ccatgacgat acaattttca 1245121 taaacgcgga gaatcgccag ctgctgcttt gacctgattg tcatattggc gataccgatc 1245181 tttccggttg agcgcagcgc ctcacgcagc agggtatagg ccttcgtccc attatccccg 1245241 gggccgacaa agtaggagcg gttaaaataa atcggatcaa tttcctgaag ctgaacaaag 1245301 tcaacaatct caactgcttt ctcctcatgc tcctgtttta agctttttaa atcttcgtct 1245361 gtcagcacta catattttcc ttttacatat tcatatccct tcacaatttc atcaggacta 1245421 agagtttttt cgcaatttgt gcaaactttc tcgtatttga ttggtgcgtg atcctcttta 1245481 tggaggctgc gcagtttaat atctttatct tctgtggccg catatagctt gatggggatg 1245541 tttactaatc cgaagctgat cgatcccttc cacattgtat gcatatcgat aaaccccttt 1245601 ttttctttag tgtgaagaga aggagtacga ttcatgtgta gtaacttatg ggtgaaaaaa 1245661 agccggcgct gttattgcga cggctgttca ataatgaatt gttcgaattg ttccggaggt 1245721 attggcctgc tgaaaaagaa gccctgcaaa tggtcgcagc ctttttcaaa aagaagctgc 1245781 ttttgagctg cattttccac accttcggca atcacctgca aagacagctg atgccccatg 1245841 gcaataatag ctccggtaat ttgctctgat ttaggatggg tctgaatatc gtcaataaat 1245901 gatttgtcaa tcttcagcct gtgaatcggg aagtccttca aatagctaag agagctgtga 1245961 ccagtaccga aatcgtcaat actgattctg attcctaatt ctgttaggga tgacaaaacc 1246021 tttttggagt gattgagatt gtccattgtc atgctttccg tcacctccac ttcaagaagc 1246081 tgcggaggaa gctggtactt attaagcgta tccttgatga ggggaatcag atctttagat 1246141 tgaaactgtc tggcggaaat attaatggcg acagaaagat catagccttt gtcatgccaa 1246201 atccttgcct gcttgcatgc ttcatctata atccactttc cgatatcaat aataagtccc 1246261 gtttcttctg caacaccgat gaattctccg ggcggacgca gttgcccgtc tggtgtcaca 1246321 aggcgtatca gtgcttctgc tcctgtcatt ttttgttttt tcacactgaa ttgcggctga 1246381 taatgcaaga caaatctatc gttttcgatt gcttctctga gtaccatctc ttggttaagc 1246441 ttaacggttt ctttgttgcc gattgaaaaa gaatagtatc tgtatttgct tttgtttcgt 1246501 tctttagccg catacatcgc catatcagcc tttttcatca attcaaggcc atccgtcccg 1246561 tcttttggag atatcgcaat cccgatactg acagatgtga caagggtgtg atcttgaatt 1246621 ttgaaaggtt ttttgaattt ttggataatt tttcttgcta aaacatctgc ttcgcctgtt 1246681 cctgtattgg cgtctgttaa tataataata aattcatcac cgccaagacg ggcgataaat 1246741 ccgttatcag ggactacaga tgacaggcgt ttagctgcaa actgaagcaa ttgatcaccg 1246801 acattatgcc ctaatgcatc gttaatcact ttaaaccggt ttaagtcaag aaagaataca 1246861 acagtgttat aatgcaagga atgctcgcga ttcagcacct ttgttagatg agagatggca 1246921 tgccttctgt taggtaagtc tgtaagcgaa tcataatgag ccattctatg gatttctttt 1246981 tctgctttgt actgcttcgt catgtcttta caaatgacat aaatgctgtc tagttcctga 1247041 ttgacctcaa caggtataag cgtaatattt aagtgaaact ggcctttttc agtgataaga 1247101 tcgctatcgc tgttcatcgc ttgtttatct tttttaactt gctcaaaaag gcgcttaacc 1247161 ttcagtgatg tgtaattcct ccagtcatgc atgctgaagc caaatttgct gatcatttcc 1247221 tcaccagcgt gattggaaga tattatgtct ccttctaatg ataaaataaa aattgcatca 1247281 atattgtgga cgattaaaga ctgaaatcgc tgttcgttat cctttatgcg ttcgctctgt 1247341 ttaataaact ttcgatctgc atgggaactg aataacaata acgtttggat acaaaaaata 1247401 attaaagtaa caaaaattga ccaatgaaac gtttgcacct ccatatggct tccgggcgga 1247461 gccatgtcct tatggaaagt tgccgcaagc atccctgtgt agtgcatgcc cgaaatccca 1247521 atgcccatta caattgaact gacgccttta tagaatataa gatgctcaga atgttttttt 1247581 acggccaagt caaagaatat ttttaacgag acgaaagagg ctgcaatcgc aatgataatt 1247641 gaaactgtaa ataaaatagg ttcgtaaata atcattaccc gggaaatggc agacattccg 1247701 atatagtgca tagaagcaat agatgcgcca agcacaactg atccggtaag cagtctgtaa 1247761 tatgtaagaa tgtgccggct gacaaaatat aatgacacaa atgatcccga aacagatgcg 1247821 ccaatggctg ccattaaagg catgaattca tattccatcg gcatttccat atggacggcc 1247881 atcatcccta caaaatgcat tgaccaaata ccgaatccca taataagtga gccgccgatc 1247941 agccaaattt tactttttaa gcctgtattg atggtgactt tccttgaaag ttcaagggaa 1248001 atatacgagg cggtacaggc aattagaata gataaacata tgagagtcgt attatatgta 1248061 acgtgtattt ccaaatggag attccccccg tatcgtgtgt tccagtcttg ttgactctct 1248121 ttattatcgg ctgcttaacc gcagagtttc agccttcaaa acgatagaaa tacgagggag 1248181 atctattttt agttcaactg accgtgaaaa atgtgttaaa atcatcttga tgttttccga 1248241 aaagagaaaa atgtatgata cataaacatg aaacaaggga gttggtggct atcgaagagc 1248301 tggttatgtc atggattgaa gcatttaaaa gcttatctta ttttggaata tttctagcgc 1248361 tcagcattga gtttattccg gccgaagtcg tcttgccgct tgcgggctat tgggtatcta 1248421 aaggcgatat gacacttgct ggcgttgttt tggcaggatc gcttggagga gtggccggtc 1248481 cgcttacgct gtattggata ggccggtacg gaggaaggcc gtttcttgaa cgttttggga 1248541 agtatctctt tattaaacct gaagcgcttg ataagtcaga taattttttc aaaaaacatg 1248601 ggggctttgt cgccttcagc ggccgtttct tgcctggtat caggacattg atttccatac 1248661 cgtgcggaat tgcaaaaatg aatgtttggg tgttttcgct ttatacattc attgctatgc 1248721 ttccgattac atttgtatat gtttatctcg gtgtgaagct cggtgaaaat tggaaggcag 1248781 tcggctctat tcttgatcaa tatatgcttc cgatcgggat agcgattttg gcgctgttcc 1248841 tgctctactt actgatgaaa aagaggaaga aacgcacgca ctccgaacaa ttatctgtat 1248901 ttttgaaaaa taaacgttga caaatcactg cgctgcgcat attattgacg tataaaatca 1248961 tatttcttga aatcccaaag gggagtagcg tccggaatgt attccggaaa caaagtcgtc 1249021 atttcatgga ttgtatccat cggctttgtt ggcatgcctg aattcatgtc tagcaagacc 1249081 tttgccttat gtcggcaaag gtcttttttg catggtccgg ccggcataag atcggatgaa 1249141 gagaaagaaa acaacttttt tgggagggta tcatttatgg atgcagcatt attattagag 1249201 tatggttggg ttcttctcgt cttgatcggg ctggaaggga ttttagccgc cgataacgcg 1249261 ctggttatgg cggtaatggt aaaacatttg ccggaggaaa aaagaaaaaa agcgttattt 1249321 tatggattgg caggggcttt tgttctgcga tttggctctt tatttgcaat ttctttcttg 1249381 gtcaacgtat ggcaggttca agcgattggc gcgatctatt tgctgtatat ctcagcaagc 1249441 cacttattga aaagatatgt atttaagaaa gaagacacac ataaagagac gaagcaaagc 1249501 ggtttttggc cgactgtttt aaaagttgaa ctggcagata tcgcgtttgc tgttgattcc 1249561 atcttagcag cagtagcgct ggcggttaca cttcctggga catcactccc gaagatcggc 1249621 ggacttgacg gaggacaatt tctcgtcatt ttggccggcg gtatcatcgg actggtgatc 1249681 atgcggtttg cggcttccat gtttgtgaag ttattaaagg aacgtccaag cctagaaaca 1249741 gcagcctttg tgattgtcgg ctgggtcgga gtgaagcttg ctttatatac gcttgcccat 1249801 cgcgacatag cggttgtttc tgagcacttt atccattctg gaacatggaa gctgatattc 1249861 tggggtgtct tagcagcaat cgcggtttgc ggctggttta tgtcaggtgg gaaaaaacag 1249921 ccggagggtg cacaaaacga acaaaaaaac agcacccgtg aacgggcgta atctgaaaga 1249981 ctctgcttaa aagcagagtc tttttgtgtt tgaagcgttt tcataagcga aataaaataa 1250041 catttttata acatctttgt tacaaaaaac acgcataaaa cccccttaat tctttagaaa 1250101 ggcacgaaat catgtataga acgtcagaat ggtttgtcat aattgagaca ttggaaatca 1250161 atatttcttt ttctcctttg cgaatcccta tcaaattagc tatcattaat gagtagttat 1250221 agggaggaac tgaggtgaaa ccagtgctta gccttttgtt taaattggga aaaaagaagc 1250281 aaacacttga aaaagctgtt gagagtatac aaaaaggcaa taaagatctg caaaatgaat 1250341 taatacagca atataagcca tttatcgcaa agacggtttc atccgtttgt aaacgatata 1250401 tagatgaaaa agacgatgag ttcagtattg gactgatcgc gtttaatgaa gctatagaaa 1250461 aatattcacc tgaaaaagga aattctctgc tcgcatttgc tgagcttatt ataaaaagaa 1250521 aagtcattga ttacattaga aaagaagcca gaagcgcaca aaatataaat atcgatttac 1250581 aggaaggaga cgatcaggag tcatcacaaa gcctgattga agccgagctt tccattgatg 1250641 aataccgccg tcagattgaa caggagcaga ggcgggagga aatcctctat tttcaaaagc 1250701 agctcaagga ttatggttta tcgtttaaag aactgcttga aaattctcca aaacacacgg 1250761 atgcaaggca aaacgccata aaggtggcaa tgacgcttgt tgaacatgaa gaattggccg 1250821 ctatcctgta tacaaagaag cagcttccgg tcaaacagct tgaacagctt gtctctgtaa 1250881 gccgaaaaac gattgagaga aacagaaaat atattattgc gatgtgtatt atcattacgg 1250941 gtgattatat ttatttaaaa gattatctta aaggggtgct gcactcatga gaagagggat 1251001 tatagtagag aaaaataaaa aattcgtcac gttgctgacc cctgacggac aatttttaaa 1251061 agccaaaaat gatcgacaca gctatgaaat cggagaagaa atcatgcttc cgagtgaaac 1251121 acgcatgggc agaagggcca gcttttttga tttttttaaa ctgcgccctt tcaaaatggg 1251181 gatttttacg atgactgcta ttatgctctt tatttttata gttctccccg ttttttctaa 1251241 taataaggcc tatgcgtata tgacaatcga tatcaatcca agcgtcgaaa tggcgttaaa 1251301 cagcgattat gaagtgattg aactgacgcc tctaaacgat gagggacaga aagtcgtgaa 1251361 tgatatagat gattgggaga agactgattt taaaaaggtg attgacgata ttataaccga 1251421 ctgcagtgaa cacgggtatg taaaaaaatc gaaagaaata ttgatttcca ctgtttatga 1251481 aaacacagaa gacaatacat ataaaaaggc tgtgaaaaaa cagctgaatg atgtgactga 1251541 aaaatataaa acgacatacc gcatggaatc tctcgagtca gatatgcaaa cgagggaaaa 1251601 agcgaagaaa gaaggcgtct caacaggcag ctacatcaaa tcaaatgaaa agaatgacaa 1251661 taaagatata aaagatgact ccagcaaacc atccggggaa gaggatcaaa agagtgatga 1251721 aaatgaggat gaaaacaccg atcaaactga cacccaggac agcaagcaag gagataatga 1251781 acagctgaat gatgcggatt ccggagacca gaaagaagag aaagcggatg accagattga 1251841 tgatagtgac aaagataaaa aaataaagga atcagatgaa aacacaaata ccgaaaaaga 1251901 tggggaccat gagcaaaccc caatacaaga tcctcaagat aaaggaaatg aaaataacgg 1251961 cgctgacaag ggccaaagcc aatatcacag ggactggaac aatggtgaac aaggcaagaa 1252021 ccgttcttcg tccagaaggg ataacgcttc agaccgacgt aatccaaacg gctacagcag 1252081 tgataatcat tcagctaaaa atgaagattc gccgagtgcc cccggcgaat aaagacctga 1252141 atttatttag ttgtgccatt taattgtgat tgtgcttgct gtaccagccg ctttgtcatt 1252201 tctccgccta cagagccgtt agcgcgtgcg actgtatcag aaccaaggtt cacaccgaat 1252261 tcttgagcca cttcgagttt aaattggtct agtgcctgct ccacccctgg aacaacgagt 1252321 ttatttctgc tcgccatctt tttcatctcc tttttcgata aagaaattct taacgcgtat 1252381 ttagtttgaa atatacgggg tttatttatg ctggcaattg ttgtggagaa aaataaaacc 1252441 ccggcctctg agccggggtg gcgcagacta tagaatgtct gctgtcattt tatgtgcggt 1252501 tgcctgaata tggaatgtca aaatggagag gactgtaatg gcgataatct gtctgatttt 1252561 aagccattgg ctgtcattca gttcttcaaa acggtgacgg agacgctctg tctcctgttc 1252621 ggcgatctcc tgcagatttg attctttcat agaaggagta tcttggtgat ggatggcatc 1252681 aagcacatat gcgcagcttt cataataagc aatcgggctg atgacatcat cagatctgtc 1252741 tgagattgtg ttaaaggcca cttttaaaat agcccgtatg tgttcaaagt cataaatgga 1252801 ttttaaatca cgtacaatta aaagaataac tgcctgttca attgagtatt ttttgcccag 1252861 ctcagggtgt ccgatcagat ctttgatatc acgctttacc cagttttgaa tcgcggttga 1252921 ctttaacgaa gtcagctcgc ataagttgcc aagctctacg atttcatttg tagacagacc 1252981 gtattctttt ttctgttttt ttcgttcgta tcttgtaaga aattcaggaa tttctagatg 1253041 attggctgct ttttctgctg acatgttcgc tgattggacg agaatgtcga gcgggctatg 1253101 ttctccttgt ccttttaggg aatagagcag ccgcaccata tcggttcgag agagtttaaa 1253161 aatgttcatt gttcacctct ttaaacaatt tgacgcggat ataggtctat gtataagttc 1253221 aaaattcaag cgtcagcaaa ttacattaac atcatacgtc gaattccttg cattttcaaa 1253281 tggatgtttt ataatttaaa tatacgggtt cttttgaact taaaataacg gaggttgtta 1253341 tggcgaaaag aatttttctg tttattctaa cgaatatttt ggtgcttaca acaatcggga 1253401 tcgttttgtc tgttttaagc tctgttacag gagtcgggac gtactttaca gctgatggcg 1253461 gtatcgatcc aatggcgctt cttgtgttca gtttagtcgt tggatttgtc ggttccttta 1253521 cgtctcttgc gatatccaga tggatggcaa agacgatgat gggcgtcaga gtgctgaatc 1253581 cgaaaaaaca ctcgctcagc tatgaggaac agcaattggt tgatcgtgtt cacagattaa 1253641 gccgctctgc cggtttaacg aaaatgccgg aagtcgggat ttaccgttca cctgaagtaa 1253701 acgcgtttgc gactggaccg tcaaaacgcc gttcacttgt cgcagtatcg tcagggctgc 1253761 tggagcagat ggatgacgca gcagttgaag gtgtgcttgc ccacgaggtc gcgcatatca 1253821 caaatggtga tatggtaaca atgacgcttt tacaaggtat cgttaatacc tttgtcgtct 1253881 ttttatcgcg tatcgccgct tggatagcaa gccgttttgt caaagaagat ctagcgccga 1253941 tcgttcattt tattgcaatg attatttttc agattgtctt ttcgatactt ggcagcctgg 1254001 ttgtgtttgc gtattcacgc catcgtgaat tccatgctga caggggagga gcggatcttg 1254061 ccggcaagga caagatgatt catgcgctgc ggacgcttaa aagctattct tcccggattt 1254121 tggaagacga tcagacagct gtccaaacgt taaagattaa tggcaagaag cgctcttcac 1254181 ttttctctac tcatcctgat ttagatgagc gaatcagacg gctggaagct aaataataca 1254241 aacacattgt tcctctgaga gaattctcag aggtttttta ttttatccat tgactaaaat 1254301 cataaaaaaa taagcaagtt aagaaaatgt ttcgtaaaag cctttaaaaa tggacctaat 1254361 atctttagaa taattaccgt acttaaaaag agaggcagaa ggattttaca tgagattaaa 1254421 gtttggaaaa ttgatacagg ccttgtcacc ggcccagctg atcgcattat attattttct 1254481 tgcagttact gtggccgtta tattgctgag tttgccggcg gcccataaac cgggggcgga 1254541 ttggacgttt attgatgcgc tttttacagc tgtcagttca gtcagtgtaa cggggctgac 1254601 agttgttgat acagctgata cattcagcac aatagggatt tttatattag catttgttct 1254661 gcaatttggc ggaatcggaa ttatgacgct cggaacgttc atttggctga tcatgggaaa 1254721 acgaatcggg ctgaaagaac ggaagctgat tatggttgat caaaaccaat cccagttttc 1254781 aggaattgtc aatctgatga agcaggtact gtttctgatc ttgtggattg aattttttgg 1254841 cgggctgata ctcggcacat atttcttaac ctactatgac tcctatcagg aagcctattt 1254901 acacggattt tttgccagta tcagtgcaac gacaaacggc ggatttgata ttaccggtaa 1254961 ttcgatgatt ccatttcgcc acgattactt tgtgcagttt attacaatgc ttttaattat 1255021 atttggagcg attggatttc ccgtgcttgt tgaagtaaag gatttcctgt tttcaaagca 1255081 tcggcgttat ccatttacgc tttttacaaa gatcacgacg attacgttcg gctcacttgt 1255141 cttgtttgga gccattggca tctttgccct ggaagcaaac catgcgttcg caggaaaatc 1255201 atggcatgat attttgtttt tgtccctgtt tcaatcaacg gcaacccgaa gcggggggct 1255261 ggcaacaatc gatatcagcc aattatcaga ttccacactc ttttttattt gtgcgctgat 1255321 gtttattgga gcgtcgccaa gctcagtcgg gggaggcata aggacaacga cttttgcttt 1255381 gaaccttctt gcgctgtttc attttgcccg cggcaataag gccgtaaagg tattcaaacg 1255441 ggagcttcac cctgctgact tgatgaagtc gcttgttgtc acgatgatgg cgatcctgct 1255501 cgtttttggc gcgacactca ttctgaccat tacagaaaaa cattccctgc tggagctttt 1255561 gtttgaagtg tgctcggcat tcggtacaac cggcctatcg cttggaatta cggcagattt 1255621 gagcagtgtt ggaaaatgcg tcattatgat tgtcatgttt atcgggcgaa tcggcatctt 1255681 gaccttcctg tatctgatcg gaagaaagga aattgaagcg aattatcact atccgaagga 1255741 aagagtgatt atcggatagg caaaacaccg catattttgc ggtgtttttt gattaccaaa 1255801 aaaaagatgt gtgcctcctg ttcagttgga gaacctaact ccgacaggtg caatttacgc 1255861 tcctgcatct taaaatgtct gaaaattggc gaggaggatt cgtatgaagc gtaaagctga 1255921 agtgaatgaa gccattaaaa ataacaatac acctaccgag agcatggacc ccaattcata 1255981 taagacacaa tatcatgacg accccaattt tagaggggca aaccgcaatt ccaaacaggg 1256041 ccagcaggga ggcatgtaat tgtgaagaaa aaccgtcata gcagagacat gcaaaatcat 1256101 aaaaagccta tgaataaaaa ggtgctggag gaagaattct caagtgaact cggggattac 1256161 aatgccggaa agatcatcga aacgctggaa gtcaccaagc ctgaaaagaa aaaagaaaaa 1256221 aacaaaaaac aacaataaaa aagacctctt aggcggcgtc ccgcttaaga ggtgcttttt 1256281 ctattttaaa taagcatttt tgcccgttcc tctgacaaat tgcaataagc ttgtcatcct 1256341 cagctcaatg aatggctgag cgactgtctt aacaaagttg ctggagagga ctgatgtcag 1256401 ggctgctgtt aaaagcaaga ggatcactaa gctttgatag tcagtaagcc aatcctcaag 1256461 cccgacctgc cgtaatgtct taataataaa cccgtgaagc agatacacgt aaaatgtccg 1256521 ggttccccat ttggtaaaga aataccgttt ttgcggaacg agcgctaaaa agctgaaggt 1256581 tgccccaaag gcgagtacat accagccgat tcgggatagt ccgcttacca gggtaacgtc 1256641 tccaaatgaa gaatacggtt ttgaaccaaa cagaaaagaa tagtcaaaat cgatgcccca 1256701 gcagatgacg aatactgcgg caagcactcc gagcgcaatt tgtttgccgc gttttgatct 1256761 caataaatca aaatgatgtt tatttaaata aaaaccgaca aggaacatcg gtaagaatac 1256821 gaatgtccgt gacaagctca gcgtgctgct gacaaagtcc agataaccga tcagcacggc 1256881 gattccgcag ctgacaaaca gcgcccactg ctttgaaagc tttgaaaaag gatataggag 1256941 caggttccaa aagaataagc ttacaagaaa ccataacgac cattgcggat caatcgggtt 1257001 cacatttgcc atgctttcat cttgcataat gtaataaaag acggaataaa taatttggaa 1257061 aatcaaatac ggaataatca gcttgaccgc cagctttttt acatatcccg cccgtttaaa 1257121 gcctttcgcg aaataaccgg atacaagaat aaatgcaggc atatggaatg tgtaaatgaa 1257181 cttgtagagg tagagcataa aatgattatc attaataaag gaacgaagga tatgaccgaa 1257241 tacaacaagg aatatcaata aaaattttgc gttatcgaaa taactgtccc gcgatttact 1257301 catagcatca ccttctcttt catcagtcac taagagatta ttccctgctg gtacatattt 1257361 taaaataaaa gatgaaaaag gaatctaaaa aaatgctgat tgttaggtcg atgtaaagtg 1257421 acggtaagga tcgtagaaaa tgtcttcgta atgtaatgac gctgaaattt tctgaaattt 1257481 atagggcaaa tgaaggaagt tcccgcattt tgtagaaata ttgagggata ggttttgaag 1257541 aaggagtgta catgcatgga aactcttggt gtccagacaa actcggagct gcgagaggaa 1257601 ctgaatcgcc tcaaagaaga aaacgcgcga ctgaaaaagg aattgaatca gcatcaagtg 1257661 attgtcaaca atacgctcga tgctattttt atttgtgata acgaaatgcg gattgttcag 1257721 gcaaatgaag caacagaaag gatgcttcaa gttgactcgg aagatttgaa aaagcgttct 1257781 gttttggatt ttttgttttc aatcccaaag gatgaactga atctttccgt aaagaagttt 1257841 tttaaaaaag gctttctgtg gaaggaggtt ccgatcaggc ttgattgcgg ggcaacaaaa 1257901 tacatagagt ttctggccaa aagaggtatt ggtgaggatt tcttttttgt tgtcatgagg 1257961 gacatatctt ctaagaagat tctggagcgg gaattctcta tgaatgaaca gctttttaag 1258021 gacttgtttg acagagcagt tgacggaatc gtcctgtttg ataaagatgg cggttttatt 1258081 gatgcaaatt tgtccttttg taaaagcttt gaaatcaatc ataatgagct gtctcattta 1258141 tctttgtatg agttcataga cagcggctca cgaaaagatt tcgacaatat ctggaaggcg 1258201 ctcaaccgca agggaaaagc gaagggggag ctgcctgtca agcttcgttc aggagttcaa 1258261 aaactatttg aattcacgat tacatcaaac atcatcagcg gtttttatat gtccattatg 1258321 agggatatca cagagaagcg gtctatggag ctgcagctct ttaaaagtga ggagcgcttc 1258381 agagaaatct ttgaaaatgc aatggacgcc atcatcatct ggtcgaatga cggaagaatc 1258441 gtaaaagcga atcaatcagc ctgtaaaatt tttgagctgc cgatgaattt gctgttgaaa 1258501 agaaagctgt gtgattttct cgttgactcg cagcagaaat acagcataac gaagaggaaa 1258561 tacgcaaaat acggagagat cagagaagag ctgctgtttc aaatggggaa cggccaattc 1258621 aaagagcttg aatttacttc aaaacggaca atccttgaaa atcagcattt gacgatctta 1258681 agaaatgtaa gcgacagaaa gcggatggaa aaggagcttc gggaaagcga gctgaaattc 1258741 agaaaagtgt tcaacggatc aatggacggc aatgtattgt tcgacaatca atacaggatc 1258801 atcgacgcca acccgttagc aagccatatt ttgggcctgt cacatgaaga gatcaaacag 1258861 cacagcctgt tagatattat ttctgcttat gaaatagaaa atttggcatc accggcaagg 1258921 cagattaatt ttgatgaaat ggacaacgaa attccatttt tgctgagcag cggtgataac 1258981 agaaaactcg aattctcatt taaacggaat attattcaaa atatgaactt ggctatcttt 1259041 aaagacgtaa cagagcgaaa agaattggag gagcgcctgc gcaaatcaga tacccttcat 1259101 gttgtcggcg aactcgcagc cggtattgct catgaaatca gaaatccgat gactgctctt 1259161 aaaggcttca ttcagcttct gaaagggagt gtcgagggag actacgccct ttacttcaac 1259221 gtgatcacct cagaactaaa gcgcatcgaa tccatcatca ccgaattctt gattttagcc 1259281 aagccccagg ccattatgta tgaggaaaaa catgttaccc aaattatgag ggacacgata 1259341 gaccttctaa atgcgcaagc caatctcagc aatgtacaaa tgcaacttga tttaattgac 1259401 gacattcccc cgatttactg tgaaccgaat cagctgaaac aggtttttat caatatatta 1259461 aaaaacgcca tcgaagtgat gcctgacggc ggaaatattt ttgtaacgat aaaggcattg 1259521 gatcaagatc atgttctaat ctccttaaaa gacgagggaa tcggaatgac agaagataaa 1259581 ttaaagcgac ttggtgaacc gttttatacg acaaaggaac ggggaactgg acttgggctt 1259641 atggtaagct ataaaattat tgaagaacat caaggcgaga ttatggtaga aagtgaagaa 1259701 gggaagggca ccgttttcca tattacgctt cctgtcagac agaatgctga agaaagaagg 1259761 aatgatgaat gaactactat acgacagccg aaacgccgct cggtgaactt atcattgccg 1259821 aagaggagga ccggatcact cgtctatttc tcagtcagga agattgggtg gattggaaag 1259881 aaacggttca gaatactgag cataaggaaa cacctaatct tgcagaagcg aaacaacagc 1259941 ttcaagaata tttcgcaggc gaaaggaaga cattctccct gccgctcagc caaaagggca 1260001 ctccttttca gcaaaaagtg tggcaagcgc tggagaggat tccatatggc gaatcccgaa 1260061 gctatgcgga tattgccgct gctgtcggca gtccgaaagc ggtgcgcgct gtcgggcagg 1260121 ctaataaacg taacgacctg ccgatttttg tcccgtgcca cagagtgatc ggcaaaaaca 1260181 gtgcgttaac aggatacgcc ggaagcaaaa cggagatcaa agcatttttg ctaaacatcg 1260241 agcgaatctc ctataaagaa aaataaaaca tatggcacgt tccctttttt cacggccgac 1260301 atatcatttt attaagttaa aaaagttggt ctgatgaaaa aggaggacaa agcaattgaa 1260361 gccgagccgc tctgagaaac ttgccgtttt tgccgaactg tttgtgaaac tgcatatctt 1260421 atcaagcgct caaaaagatg aaatcatcaa tgttaacaaa aagaaacaaa aaaaccgctg 1260481 actcggctcc aaatgagcaa agtccagcgg ttttttaatg caccttttct cctttaaaca 1260541 gctgttcaat ctcttcttca tagtttccgg tcataatccc tttttctgtg atgattcctg 1260601 aaatgagatc atgaggtgta atgtcgaaag cgggattaaa gacaggcaca ttggatggag 1260661 cggtccgaac tccggaaatc tgcctgactt cctcgggatc tcgttcctct atcgggatat 1260721 cagcgccgca tttgaccttt gtatcaaatg tagataaagg tgcggcgaca aaaaacggaa 1260781 tatcaaaggc gtttgctaaa atagcaagac cgtatgtgcc gattttattt gccgtatcac 1260841 cgttctttgc aattcggtcg gctccgacga taacagcgga aatttgtttt tccttcatcg 1260901 tatgggcggc catgctgtct gtgatcagag tgacatcaat gcccccctgc atcagctccc 1260961 aagcagtaag gcgtgaacct tgcaggacag gccttgtttc acaggcataa atgtgtaatc 1261021 ccaaatcttt ttgtttggcc aagtaaaacg gagctagcgc cgttccatag cggcttgtcg 1261081 cgattgagcc ggcattgcag atcgtcatga tcctgtcgcc ttttttgaaa agctgcaggg 1261141 cgttttggcc gatcaaccgg cacgtttcct catcctcgac ctgaatctga atggcttcat 1261201 ggacaaggtt tgtttttgct tcatttacgg aaatcgcgtt ttcgaccgaa tgactcagtc 1261261 tctcaagcgc ccatgacaaa ttaatggcgg taggccgtga gctgtttaaa tattgtttga 1261321 tgtcttccag tctgcggcgg aattccgtga cattgtctgt ttcaatgtct ttggcagcaa 1261381 gcgccagtcc gaaggcagct gtaatgccga tcgccggagc gccccttact ttgagcgtga 1261441 caatcgcatc aaatacatcc tctttcgtcg tcagctccaa atattccgtc tcatcaggaa 1261501 gcttttgctg atttaaaatg gtaatagctg tttctttcca ttcaacagaa cgtggaacag 1261561 caaatgaatg ggtcatgaat agatcattcc tttacaagta acttaaataa ttcaataaca 1261621 tctgttatcg ttttgaattc cgaacgtttt tcgataaagg ctgtgccggt ttcgagcgcc 1261681 aagcgttttc tgccgattcg tttatcaaac ggcacgatcg tatccaggtc agctacatgg 1261741 gcaaggccga tcgtgcgtcg tatcagctca cagcccgcaa atccgattgc ttcttcaaaa 1261801 atatggctga gcgtatcagt gaggtaaccg tcgatgttgg cgtaaacatc cagactgtcc 1261861 ttctgccagg cttcactaaa cgtctcttca aacgtttccc agacctggtt gacatgttca 1261921 tataacggct ctctgtcagc cccgtcacgg ctgagtgcgt tcaaaaataa gttggcgata 1261981 aattgcccta catcaaagcc gatcggtccg taaaaagcaa actcaggatc aatcaccttt 1262041 gtttcgtgct cacttgcgaa aatgcttcct gtatgcaaat caccatgaat caacgtttct 1262101 gcagacgtta aaaatgactt tttcagctta gcggcttcga ttttaacgct gtcattattc 1262161 caaagctttt cgacaaaagg acgaagctct tcttcaaaat catttgtgtc atggtcgaag 1262221 aaaggatctg taaaaacaag tctttccgta atgtcgcata gctctggatt tgtaaactgt 1262281 ttaacaagct gttttttcac cttaggttca agcgcgtaat ctgatgagta gaaaagtgtt 1262341 tttcctaaaa attcaccgat gtgctgcgac agatgaggat agttttcacc ctcaatgagt 1262401 ccttttcttg cgatcttgag gtgagagaga tcctccatga cggtaaccgc catttccgta 1262461 tcagaataaa acactcttgg aaccaggtga ggcacatgct cgccctgacg gatgagagcg 1262521 ctgctttcga ttcttgcacg gtcgattgtc agcggccagc tttctcccac cacttttgca 1262581 tacggaaccg cctgtttaat gatcaatgct ctgtcatgtt cttgatcata aatatgaaaa 1262641 acgtaattta agttgccgtc tccgatctcc tggcatgtca gcgtgctttt gcttggaaat 1262701 aggccaagct tcaccgccaa cgccacagcg gagctttcat ttaacgtttc gtataaaggt 1262761 gtttttgtga ctcccatcat cataacctcc aattatgtaa ttaattaata tgtggccgta 1262821 aaaaagcctc cttctcagag agaaggaggc ttaacatcta tgtccgcctc tcttatctct 1262881 cagatcagat ctgaatggaa ttagcaccgt gccttaagag accagcgtct cggcgcgaaa 1262941 aaaatgcgcc ccatttcaca atggaattac ggtcggttgc ttttggggtc aaaaggccaa 1263001 atccctcgcc caactctcga taagagaata tattcacttg tttgacaatt ctaatttatc 1263061 agttgatgaa catggtaaca ggtaatttag ttagttgtca atatattttt taatataaat 1263121 cttttctgat atcatcgaaa acaggaatgc tctcccgaac ttctgcgctt tcttgaaggt 1263181 cgatttccgc tcggactatg ccttcttccc ggccgccttc agcaagtaca cgtccccatg 1263241 gatcaataat caggctatgt cctgcaaatt cattatccgg atttgaaccg gtacaattgc 1263301 aggctgcgac aaagcattgg ttttcaatgg cccgcgcaat aagcaggctt ttccaatgat 1263361 caaggcgggg aagaggccat tccgcagaaa taaacagcac gttggcgcct tttgtcgtat 1263421 gttttctgat ccattccgga aaacggatat cgtaacagat caatccagag cttttgacgc 1263481 cgtcaagctc aaagtatccg tcttcggaac cggctgataa atacagatgc tcatccatca 1263541 gctgaaaaag atgggctttt ctgtactctt taatgatttg cccttcctta tccgcgatgt 1263601 acattgtatt ataaacatca gaattcttcc tgacagcgac cgatccggcg acaatatgaa 1263661 caccatgttt ttttgccgtt ttcttcagcc agctctgagc ggagcggccg tcttcgtcag 1263721 cgagttcatc aagattggcc agatcatatc cggtcgtcca taattcaggc agaacaagaa 1263781 catcagcatg tttgctttct ttttcgatga aaaattcagc cttttttata ttttccgaag 1263841 gttttccgta tgaaatatca aattgaagac aagatatcgt ccatttcatc tttttaacac 1263901 cccaaatttt tctttacttt tttcatttaa ccatatatga tgatggacta tcatttcaag 1263961 atttttttag aaggtgagaa tagatgaaat ttgaacagtc tcatgtattg aaggaattgc 1264021 ctaaacaatt cttcgcttct ctggtgcaga aagtgaaccg aaagcttgca gaaggacatg 1264081 acgttatcaa tctgggacag ggaaatccag atcagccgac tcctgagcat attgttgagg 1264141 agatgaaacg agctgtcgct gatcctgaga atcataaata ttcgtctttt cgcggctcat 1264201 accgtctgaa gtcagcggct gctgcatttt acaaaagaga atacggcatt gatctggatc 1264261 cggaaaccga agtcgctgta ttattcggcg gaaaagccgg tctagtcgag ctcccgcaat 1264321 gcttgttgaa tcccggtgat acgattttag ttcccgatcc gggttatcct gattactggt 1264381 cgggtgtcac acttgcaaaa gcaaagatgg aaatgatgcc gctcgtaaag gacagagcgt 1264441 ttctccctga ttacagcagc ataaccgctg aaataaggga acaggcgaaa ttgatgtatt 1264501 tgaattatcc gaataatccg actggagctg ttgctacttc cgagttcttt gaagataccg 1264561 tgcgttttgc ggctgaaaac ggaatctgcg tcgttcacga ttttgcttac ggcgctgtag 1264621 gatttgacgg ctgcaagcct ttaagctttt tgcagactga aggtgcgaag gatatcggaa 1264681 ttgaaattta cacgctgtca aaaacgtata atatggcagg atggcgggtt ggctttgccg 1264741 tcggaaacgc ttcggtcatt gaagcgatca atctttatca agaccatatg tttgtcagtc 1264801 ttttcagagc gactcaggag gctgcagcag aggcactgtt agccgatcag acgtgtgtgg 1264861 cagagcaaaa tgccaggtat gagagcagga gaaacgcttg gatcacggca tgccgggaaa 1264921 tcggctggga tgtaacagct cccgcaggtt ctttttttgc atggctgcct gtgcctgaag 1264981 gctatacttc tgagcagttc tcagatcttt tgctggaaaa agcgaatgtg gcagttgcgg 1265041 ctggaaacgg cttcggtgaa tatggcgagg gctacgtcag agtcggactt ttaacaagtg 1265101 aagaaagact taaggaagcc gcttatcgaa ttggcaaact gaacctgttt acccaaaaaa 1265161 gcattgacaa gaccttataa cgatgggata attcaaaata atttataaaa tctatatttt 1265221 cttatcaaga gcaggcagag ggacgagccc gatgaagccc ggcaaccgac ttataaagca 1265281 cggtgctaat tcttgcagct agcggctgag agataagatt cggacgagaa acgaaacctc 1265341 tttagacgcg attgcagttt gaagaggttt tttgatatgg atgaaaatga aaggagctct 1265401 ggcatgagtg agttattagc gacatatctc ctgaccgaac cgggagccga tacagagaag 1265461 aaagcagaac aaatcgcaac aggattgaca gtaggctcct ggactgatct gccccttgta 1265521 aaacaggagc aaatgcaaaa gcacaagggg cgggtgataa aagttgagga gagagaggga 1265581 actgctgcat cagaaaaaca agcggtcatc acaattgcct atcctgaaat caatttctct 1265641 caggatattc cggctttgct gacaacagtg tttggcaagc tgtccctgga cggaaaaatc 1265701 aaattaatcg atcttcactt ctctgaagca tttaagcgtg cactgccggg accgaagttt 1265761 ggcgtatacg gcatccggaa gctgctggga gagtttgaga gaccgctgtt aatgagcata 1265821 tttaaaggcg taatcggaag ggacctgagt gatattaaag aacagctccg gcagcaggcg 1265881 cttggcggag ttgacttgat taaagacgat gaaattttct ttgagactgg tctagcgcct 1265941 tttgaaacaa gaattgcaga aggaaagcaa atattgaaag aaacgtatga acaaaccgga 1266001 cataaaacgc tgtatgcggt gaatttgacc ggacgtacgg ctgatctgaa agacaaagcg 1266061 agacgcgccg ccgaattggg agcggatgcg cttttgttta atgtcttcgc ttacggcttg 1266121 gacgttatgc aaggccttgc agaagatcct gaaatcccag ttccgattat ggcgcatcca 1266181 gcagtgagcg gagcgtttac gtcttctccg ttttacggtt tttctcacgc tcttttactc 1266241 ggaaaattaa accgatattg cggtgctgac ttcagcctct ttccgtctcc atatggttcg 1266301 gttgcgcttc caagagcaga tgcactggcg attcatgaag aatgtgtgag agaggatgct 1266361 tttaaccaaa catttgctgt tccgtcagca ggcattcatc ccggcatggt tccgctatta 1266421 atgcgtgatt tcggcataga ccacattatt aacgccggag gaggcgtaca tggacatccg 1266481 aacggtgccc aaggcggggg gcgagcgttc agagctatta ttgatgcggt cctagaggcc 1266541 cagccgattg atgaaaaagc cgaacaatgc aaggatctta agcttgcgct agataaatgg 1266601 ggaaaggctg aagccgtatg acgactcgaa aaccttttat tatttgtgat tttgacggaa 1266661 caatcacgat gaacgacaac attataaata tcatgaaaac atttgctccc ccagagtgga 1266721 tggcattaaa agacggcgta ctttccaaaa cgctgtcaat caaggaaggt gtcgggcgga 1266781 tgttcggcct tctgcccagc agtttaaaag aagagattac aagttttgta ttggaagatg 1266841 caaaaatcag ggaaggcttt cgggaatttg tagcatttat caatgagcac gagattccgt 1266901 tttatgtcat aagcggtgga atggactttt ttgtatatcc tttgcttgaa ggcattgtgg 1266961 agaaagaccg catttattgc aaccatgctt catttgacaa tgactatatc catattgact 1267021 ggcctcattc ctgcaagggc acatgcagca atcaatgcgg gtgctgtaag ccgtcggtca 1267081 tccatgaact ttctgaaccg aaccaatata tcatcatgat cggtgattcg gttacagatg 1267141 tggaggcagc aaagctgtct gacctatgct ttgcaaggga ttatttatta aacgaatgcc 1267201 gggagcaaaa cctcaatcat cttccgtatc aagattttta tgagatcaga aaggaaattg 1267261 agaatgtaaa ggaggtacag gaatggctgc aaaacaagaa cgctggcgag agctcgctga 1267321 agtaaaacgg gaattggcag agagagattg gtttccggcg actagcggca atctgtcaat 1267381 taaggttaca gatgagcctt taacatttct cgtcactgca agcggaaaag ataaacgcaa 1267441 agagacggtt gaagattttc tgctggtcga tcaaaacgga gagcctgctg aaagcgggca 1267501 ttctctgaaa ccgtcagcag aaacgctttt gcatacacat ttgtacaata aaaccaatgc 1267561 cggatgctgc ctgcatgtcc atacggtaaa caataatgtg atttcagagt tatacggaga 1267621 ccaaaagaaa atcacattca aaggccagga aattataaaa gcactcggct tgtgggaaga 1267681 gaacgcagaa gtgaccgttc cgattataga aaatccggca catatcccga cgctagcggc 1267741 actgtttgcg gaagagattt cagaagattc aggagctgtt ctgatccgaa atcatggtat 1267801 tacggcttgg gggaaaacag catttgaggc aaaaagagtg cttgaagcgt atgaattttt 1267861 gttcagctac catttgaaat tgaaaacact cgagcatcag ctggttaaat aaaaggagga 1267921 attgaaatgg ctacaattcg aattcatgat gaggcaaata caacgattga aaatcaagag 1267981 gaagtggcaa gctttctgga cagtcaagag gttatttatg agcaatggga tatcacgagg 1268041 cttccggaac atctctcaga gaaatatgac ctgacagaag aagaaaaaca gcaaattctt 1268101 gataccttcg aaactgaaat taaagatatc tcaacccgcc gcggctataa agcacaggat 1268161 gttatttcat tgtcagacag caatccgaaa cttgatgaac tgcttgaaaa ctttaaaaga 1268221 gagcatcacc atacagacga tgaggttcgt tttattgtaa gcggacacgg tatttttgtc 1268281 attcaaggcc aggacggcac gttttttgat gtccgtttaa accctggaga tttaatctcc 1268341 gtgcctgaga atatccgcca ttacttcacg cttcaggagg accgcaaagt tgtcgcggtg 1268401 agaatttttg tcacaactga aggctgggtt cctatttatg aaaaagacag cgtgaatcaa 1268461 taagcgtgag atagccccgt tcatcgaacg gggcttttta tatttattgc aaacgccact 1268521 tttcatattg tgacagttct tttttaatca gtgtccaaat caaacctaaa acagctgcat 1268581 cgtcaatgaa tccaagaccg aggattacgt ctggaatgat atcgagcggc atgacgatat 1268641 acaggattgc ggcagttaac agcaaaagtg ttttaacctg tgaacgaggg tagtcgccat 1268701 ttcgccaatc gcgaagcatc tgaaaaaaag tagtgatgtg ctggatacat ttttttcggt 1268761 ttttcctctt taaaatcgct tttccgcctg ccgctccgag cattattgct ttctttttct 1268821 tcattgggca tacctcctgc ctggcggcgt gtttaagata ttcttcacct gggtattgtt 1268881 cttctaatcc tatcaatata tctattatac ctgaaaaatt aacttattta atgaaaatat 1268941 gtttacaaat aaagtataat ctgtaataat gcacaataac ccaatcaaac ttgtttccta 1269001 tttcttagcg gcgaggggtg aagtgaatgg gcggttcttc tgaacaagaa agattgttgg 1269061 tgtctattga tgaaaaaaga aagttaatga tagatgccgc tagaaagcag ggatttacag 1269121 ggcatgacac gatcaggcac agtcaggagc tggattgttt aataaatgaa tatcatcagc 1269181 ttatgcaaga aaacgaacat tcccaaggga ttcaaggcct tgtaaagaaa ttaggcttgt 1269241 ggccccgcag agatgttatg ccagcatatg atgcaaataa atagcggcct atcagatgca 1269301 tatataaaga gagagctttt cggaagcgct ctttttttct ggaaaaaatt catatgaaag 1269361 agggaactaa tgaaggaact ggcgattctc attaccgaaa tggtcaatca atttcatgat 1269421 gcttttattt ccttatgcgg aatatttggc attcatttaa ctgacaaaga aatgcatttt 1269481 tgggtgatcg gcatttttgg catattcttt ttcggcgtca ctcacgctgt gtttacatgg 1269541 ctttctaaat ggagtatgac agccttgtcc tttatctata ccgttacagt catcattgtc 1269601 atcgtatttg cgattgagat tcagcaaaag gtgacgggga gagggaatat ggagttttta 1269661 gatgccacgg aaggtataaa gggtttttta gtatttttta tgtttttttt gcttttgaaa 1269721 atgctgttgc gtttcatcaa aatccttttt tctggaagac cagcaagcaa atcgaatggc 1269781 aatgcccgat cacgaagata aaaaaccctc ctgacatggt caggggggct atgatgcgga 1269841 tacggggagg gtgatcgtca cctctgtgcc tcttcgcact tcactttcaa tatgaataga 1269901 gcctccgtac atcagcacga tccgtttaca aacaacaagg ccgagaccgg ttcctttttc 1269961 tttagaagta acaaagggaa ggaagatgtg atccagcatt tcctgagaaa tcccttcacc 1270021 gttatccaca actttgatta tggctttttt atctaaagct cctagggaga tcgtcagttt 1270081 gcctccttca ggcattgact cgaggccatt ttttgctaca tttaaaatca cttgtttaat 1270141 atgatctttt gtacatttta cgagtaaggg ctgctcggtt agatactgta attcgacttc 1270201 aacattgtat agattgccct cagaataaat gatcggcata atttctccga taatgtcctg 1270261 aagtgagttc agctcccatt tttcagctgt cggcttgccg agaacgagaa actcactcac 1270321 tatttgattg atgcgcttta tctcctgttc gataatggag aagtaaagct gatcttcctc 1270381 acctttatat ttcttttgca acagctgaat aaagccgctt atcccggtga gggggttacg 1270441 gatttcatgg gctgtgctgg cagcaagcgt cccgatcagc tctaattttt gcgcctcgtt 1270501 ttctgagcgc tccagctggg tctgccgctt cagcaaataa tacagcacga gaataaaaag 1270561 gatattcagc agaacaataa tacatgaaag cggaagcaca aggcttttcg acagttcttc 1270621 tattgtgacc gggttcggat agactttcat attccagctg atatcatcca gatatccgct 1270681 gacaggtttc tgatcctctg catgagaggc ttgtccgctc gcaaaaatca ttttcccgtc 1270741 ttggttcaca acttcaatat aaacatcagg gcttagtaag ttaatgagat ttttcaaata 1270801 atcaatttga atagctgcga caagataatc tgtcacatta cgttttgagt ccaaaacagg 1270861 cacacaaatt gtgaaaattg gctgaccagt aattctgctc gaataactat ctgaaatgac 1270921 tgtcttttta gtttcctttg cttttataaa aaaagatctg tcggccaggt ttactttcgt 1270981 ttttaattcg gttgtgcttg cggtgacgtc tcctttggca ttgagaaaat agagaccgga 1271041 aaatctcggc tctgaatcaa aggtcttttc caaaattgat tgcattttct ttatatcaac 1271101 cggtctgtcg atggcgatgg acaaggaggt cattctcgcc attgtttctc cgattaaata 1271161 attgattttg ttgcggtgaa ggtttagcag gacacttgct tcttgtttat gttctgcagc 1271221 tattgtatct ttttcttttt catatacgaa aaagctgatg acgattgccg gaatcacgac 1271281 cagtatgata taaagtttga ctctcccgca ggcgcctttt agtattttca atttgcatcg 1271341 ctccaacata cacctgatta gaggtattat atcattgttt cttcttcttt aataagaaaa 1271401 aataaccaaa aaaattagaa aaagatgttg gcaagcttac attttaaaaa agaagagaaa 1271461 tattggaaag atttttattg acattttggt ctttgtttat taatgtttct ctgtaacggt 1271521 ttctaaaagg atgattgaga catgacagaa aaatcactga agttatttat cgtgctgtcg 1271581 cgcgcgtatc ggtctattaa cgatcatatg aataagcata ttcataagca tgggctgaat 1271641 ccgactgaat ttgctgtgct agagcttttg taccataaag gcgatcagcc gctgcagcag 1271701 ataggagata aaattctctt ggctagcggg agcatcacat acgttgtaga taagctggag 1271761 caaaaagaac ttctcattcg gaaagcgtct cctacagaca gacgagtgac atttgcgcaa 1271821 attactgaaa aaggcatcgg tcttttgaac gatattttcc ctgatcacgc tgctgaaatt 1271881 gatgaaatga tcagcgtatt aagcgaagaa gaggtagaga tgtgcaccga aatgttaaaa 1271941 agagtaggat taaacgcaaa acagtttcat aataagtaaa aaaaggaagc ctgatatgtc 1272001 acaaggcttc cttttttgct atttttcatt tgtttccgct gcgcctctcg gcaaaatgag 1272061 aacttcaacc cgccggtttt tgcttcggcc ttccgcagtt ttattggaag ccaccggttt 1272121 atactcgcca taacccttgg cgctgaacac ttttgcatcg agcttggggt tttcaatcag 1272181 gagccccata aagtttaccg ctctcatgac gcttaaatgc cagtttgatt ggaattcaga 1272241 atttttaatt ggcatattat cagtatgtcc gctgataatg atatttcttg gcgggttaat 1272301 cacaagaaga tttgaaatct cttttgcaag cggcacatct tccttacgga tggtcgcttt 1272361 tccagaatcg aagaagatgc tgtctttaat cgtaatcaga aggccttcac tagtcatctt 1272421 cgtctccagc tgatgttcca gctttttatc tttgatgaac ttttccacct ggctcttcac 1272481 attttcaagt tcttcttgat cagctgcttt ttctttttct ttcttgtttt tctctttctc 1272541 ttctttttcc tttttcactt catcgatgcc gtctgactcg ttttcaggag gagtgacact 1272601 ggagtagtcc agtacaccgg ttccgcctgt aaaaacttca ttaaatgatt ttgagagcat 1272661 ttgaaactta gctgcgtcaa tcgagctgct cgcgtacagc acaataaaca atgccaggag 1272721 aagagtaagg atgtcggcgt aaggaacgag ccatgattca tcaacgtgct cgtcctcatg 1272781 cttcttcttc ttttttctcg ccattttgcg cctctccttg ttctgcaaat ttcaagcggt 1272841 ccttcgcagg aagatacatt aaaagctttt gttcgatgac tttcggtgct tgtccttcta 1272901 aaacggataa aacaccttca atcatgacct cacgcagttt tacttcctgt tttgattttc 1272961 gttttaattt atttgcgaaa ggatgccata acacataccc tgtaaagata ccgagaagtg 1273021 tggcaacaaa ggcagcactg atggcgtgtc caagctcatc tgtgttatcc atatgagaga 1273081 gagcggcaat cagcccgatt acagcgccga gtactccaag tgtcggagcg tacgttcctg 1273141 cttgtgtaaa aatagcggct cctgcttggt gcctgtcctc cattgcttcg acttcctctg 1273201 tcataatatc tcttataaat tccgcgcttt gcccgtcaac agccatgctg agcccgtttt 1273261 tcaagaaagc atcatctaca tcctcaatgc ttgcttctaa agcaagcaga ccttcgcggc 1273321 gtgcaagctg agcccattca gagaacatag gaatgagttc ctctattgtg agctgtttat 1273381 tttccttaaa taacactcga aacagcgtag gcactttttt aatttctttt gttgggaacg 1273441 caataacgac tgctgagatt gtcccggcga taataattaa aatggcagcg gggtttgcaa 1273501 gggcgctgaa actgacgcct ttcagaacca tcccgacgct caatgccaca aaagcaagaa 1273561 taataccgat taacgaagtt ttatccatag ttttcaccaa atcctttttt actagcttgt 1273621 ctatggttaa tatcggtttt ggtgcccgga actttaggga cattgtgaat ttgttcatga 1273681 aatattcaag gaagaggcat agaagggaga aataaacaaa aacgggctct ccaaaattga 1273741 aaagcccggg ggtctactga aattagcagc ttgcttgcaa gctgtccttc agatggtatt 1273801 catataatag tagaaataca tattcactgt atataaacat gttccatccc tccttaaaaa 1273861 agtgtaaagg atgaagggaa gtagcgcttc aggagaaggg acggtaattt ctaagtcaag 1273921 agtatgaaag tataaaaaaa agcggcttcc taaaaggaaa ccgctgattg ttattttgct 1273981 cgcactttga ttttatcatc ttctaaaatc acgtgaaaac ttgtgatctc gccattatca 1274041 agcagcagat cggtcatttc atcctcaacc cattcttgga tggttcttct aagcggacgt 1274101 gcaccgaatg aagggtggta gcccagctca gcgatttttt ctttcgcttc atctgtcaca 1274161 ttcaagctaa tgccccgttc cgccaatgtt tcttcaagtt ctccaagaag aaggctgacg 1274221 attttgacaa gatgttcttt ttccaatgag cggaactcaa taatgctgtc aaaacggttg 1274281 aggaactcag gtttaaagaa catgctcagt gaatcaatta atgtttgttc ttcgatgaca 1274341 ctgtcatctg attggaaacc gactttcgtt tgtttctcac cagcacccgc attacttgtc 1274401 atgatgatca cagtgtcttt gaagcttaca gttctgcctt ggctgtctgt cagacggcca 1274461 tcttccataa tttgcaggaa catatgctga acgtctgggt gtgctttttc aatctcatcc 1274521 agcaacacaa tgctgtaagg attgcggcgc accttctcag ttaattgtcc agcttcctca 1274581 tggccgacat atccaggcgg tgaaccgata attttagata cggcgtgttt ctccatgtat 1274641 tcgctcatat cgagtcggat aatagcgtct tttgtgccga ataattcatc tgccagtgtt 1274701 ttagaaagct ctgttttccc tacgccggta ggaccgacga agaggaagga gccgactggt 1274761 ctgtttttgg attttaatcc ggcgcggctt cgtcttaccg cttttgccac tttttgaaca 1274821 gcggcttctt gtccgatcac gcgttcatga agttttgctt cgagttcttt cattttcgtt 1274881 tgttcgtctg cctgcagttt gccgacaggg atgcctgttt tttgttcaac aatttcctga 1274941 atgtgctcag cttccacagt gacagcggta tgagcggagg agctgttcag ttttttctcc 1275001 aatgcgagtt cttcatcacg gagttttgcc gccagttcgt aattttcttc ttccagggct 1275061 tttgtttttt cggcttcaat tgcagttaag cgttcagcgg catcctcatc attcagttca 1275121 tcaattaaca ggttggcttt tgaacctgct tcatctaata aatcaattgc tttatccggc 1275181 aggtgtctgt cctgaatgta gcgggatgat aaagtgacac atgctttgat tgcttcatca 1275241 ctgaatgtta cgccatggta cgcctcgtat ttgtctttaa tcccttgcag aatgaggata 1275301 gcctgttcaa ttgaaggctc ctgcaccatg acaggctgaa aacgtctttc cagcgcggca 1275361 tctttttcga tttgacgata ttctttcagt gttgtcgcgc caatgacttg cagttcgcct 1275421 ctggctaggg ccggtttgag aatgttgccg gcgtccattg atccttctgc agagcctgcg 1275481 ccgacgagaa ggtgaatttc atcaatgaac agaatgacat tttttcgttc cttcagctca 1275541 gtgatcagct gtttcattct ctcctcaaat tggcctctga tccctgtgtt tgcaacaaga 1275601 gatgcaacat caagcaagta tagctctttg ttttttagtt tgtttggaac atcaccttca 1275661 gcaattttta aagcgagccc ttcagcgatg gcagttttcc ctacacccgg ctcaccaata 1275721 agaaccggat tgtttttgtt tcggcggttt agaatttcga tcactcgcgc cacttcatca 1275781 tcacggccga tgacgggatc aatgagaccg gcttttgcac cgtttgtaat attttgagcc 1275841 agctcatcaa gcaacccttt tttttcgctt tgttttgctg cgctctgttc tttcggctgg 1275901 aatgcctgtt caaacggaaa tccgaaagat tgaggaccca tactcattga aggtttacgg 1275961 gtcagttcgt tatagcaagt ttcacaaaga accatctgtt tatgaacgga atttatttgc 1276021 atgttaaggc gaatcgtcgc ctcgttttga tgacaatgtt gacaacgcat ttgccaaaac 1276081 ctccttaata atttgatcat ctttgaccaa tgaaagtgaa taaaaaggtc tattgggttt 1276141 gaccttcttt gactattagt atacggcaaa cttaacggca ttcaaaccaa tatgctcaaa 1276201 gcagactgaa tatttgacta tctttgacca attgattttt aaaaaaggcc ggtttgtttg 1276261 accaactttg attaatagta tactctgact atctttgact ttcaagtctt atgcacaaaa 1276321 atttttgatt tgttacaaag taaaacatgt tttcttcgtc ttttcaagga acttgtctca 1276381 taggttataa aaaggcatat atggacaaaa ctgcggttcg ttcggaggga agaaatggaa 1276441 caatcaaaag ggtctgcaag tcagcttgct tttgtgtatg tcggcacagt agtcggagct 1276501 ggatttgcga ctgggaggga aattgttgag ttttttctga agttcggctg gttcggtttt 1276561 ttcggcattc tcgtcagcgg cggaatgttt acgttactgg gggccaagct gatgatcatt 1276621 tcaaagcgaa tcaatgccaa gtcatatcaa gaaatgaaca tatttttgtt cggggcgacg 1276681 gctgggcgga ttatcaatgt atttatgctg tttgttctcc ttggagttac atctgttatg 1276741 ctttcagggg caggggcgct ttttgaggaa cagctgggga tgtccgctca gattgggatg 1276801 ctcattacaa tcggtctgag tttaattgtg atgactagag gagtaaaagg cattttcggt 1276861 gtcaatgtgt ttgttgttcc tcttttaatc atcttttcaa tgattgtggt ggccgactct 1276921 tttatattca gcgaatcacg aaacgcagct cagtgggtct ggccgcatcg ctgggattgg 1276981 ctgttatcag cagtttctta cggggcttta aatttatcgc ttgcccaagc tgttttggtt 1277041 ccgctggcga atgaaatgtc atcggagaaa gtgataaaaa aaggcgcttt aatcggaggc 1277101 acgatgctga cgattgtgct gtccgcgagt tttctgtctt tgtcgactct tccggatgta 1277161 tttttgtatg atataccgat ggcgcaagtg gtttatctct ttgcacgatc tgtccatttg 1277221 atttatttac tcattatttt cggagaagtg ttcacatcag ttatcggtaa tctatatgga 1277281 ttagaaaaac aagtgcaaag ctttcttcca gtgaaaagca aatatatctt tgcagccatt 1277341 atgatcacgg cttatattac gagccaaata gggtacggca ggcttatttc aacgatttat 1277401 cccttgtttg gctatgtgag cctggccttc ataggcgctt tgctttgcaa aaaagctcct 1277461 cggcggcgca gtttataaat atatataatg aaacgaaccg tcactataga gcgataattg 1277521 atctaggaac cggggactga cttttttatt gtcaagaaaa acatcattat ggtaagatag 1277581 cagaagtgaa aaaattgaag aaaatccgtg cgatatgcgg gagaggttct agctacaccc 1277641 tctataaaaa actaaggacg agctgtatcc ttggatacgg ccttttttat gtttttctag 1277701 agcaccttcc gaaaaaaggt gtttttttgc gtgaattagc tgtagcgatg tctctcgccg 1277761 gcgtttttat tgcggagaag gagaggaatc atgaaaaaag aaaaagcaat tgtcgtattt 1277821 agcggcggtc aagacagcac aacatgctta ctgtgggcct taaaagaatt cgaagaagtc 1277881 gaaacggtga cttttcatta taatcagcga cattcgcagg aagttgaagt ggcaaaatcc 1277941 attgcggaaa agcttggtgt gaaaaatcat ttgcttgata tgtcactttt aaatcagctt 1278001 gcaccgaatg ccctgactag aaatgatatt gagatagaag taaaagacgg cgaactgcca 1278061 tccacattcg ttccaggccg caatttggta ttcttatcct ttgcgtctat cctggcttac 1278121 caaattggcg cgcgccacat tattacagga gtttgcgaga cagacttcag tggttatcct 1278181 gactgccgtg acgaattcgt gaaatcttgc aatgtcacgg taaatctggc aatggagaag 1278241 ccgtttgtga tccacacgcc tctcatgtgg ctcaataagg cggaaacgtg gaagcttgca 1278301 gatgagcttg gcgcgctgga ttttgtgaaa aacaacacgc tgacatgcta taacggcatc 1278361 atcgcagacg gctgcggcga atgtccggca tgtcaccttc gttcaaaagg ttatgaagaa 1278421 tatatggtga tgaaaggaga gcgtgcataa attgttatct caaatttatc cgcaggccca 1278481 gcatccttat tcgtttgaac tgaataagga catgcatatc tcagccgctc attttatccc 1278541 tcgggaaagt gcgggagcgt gcagcagggt tcacgggcat acgtataccg taaatataac 1278601 cgttgccggc gacgaacttg acgattcagg ctttcttgtc aatttcagcg tactcaaaaa 1278661 actggtgcac ggaaactatg atcacacgct attaaatgat catgaagatt tttctcagga 1278721 cgaccggtat tcgctgccga caactgaagt cgtggcgaaa acgatttatg acaacgtaca 1278781 ggcttattta gacactttgg agaataagcc gacctgtgta caggtgtttg tccgtgaaac 1278841 accgacaagc tactgtgtct accgtccgaa aaagggtggt ttgaatggct aaaggaattc 1278901 ctgtattaga aattttcggc ccgacgattc aaggagaagg catggtgatc ggacagaaaa 1278961 cgatgttcgt ccggacagcc ggctgcgatt attcctgcag ctggtgtgac tccgctttca 1279021 cttgggacgg gtctgctaaa aaagatattc gctggatgac ggcggaggag atttttgcgg 1279081 agcttaagga cattggggga gatgcgtttt ctcatgtgac gatctcaggc ggcaacccgg 1279141 ctctgttaaa acagctggat gcttttattg aactgctgaa ggaaaataac atccgtgcag 1279201 cgcttgaaac tcaagggacc gtttatcagg attggtttac gctgattgat gacctgacaa 1279261 tttctccaaa accgccaagc tcaaaaatgg taacgaactt tcaaaagctt gaccacattt 1279321 taacttcact tcaagagaat gatagacagc atgctgtcag cttgaaggtt gtcatcttta 1279381 atgatgaaga tctggaattt gccaaaactg tgcacaagcg gtatccggga atcccgtttt 1279441 atttacaagt cggaaatgat gacgtgcata cgacagatga tcagtcactg attgcacatt 1279501 tgcttggaaa atatgaagcg cttgttgata aggtagctgt cgatgcggag ctgaatctcg 1279561 tcagagtgct cccgcagctg cacaccctgt tatggggcaa caaacgcgga gtataataga 1279621 aaggaagatg aacatgacga caagaaaaga atcagaatta gaaggtgtaa cattgctagg 1279681 caatcaaggt acaaattatt tgttcgaata tgcaccggac gtgctggaat ccttccctaa 1279741 taaacatgta aaccgtgatt actttgtaaa attcaattgc ccggaattca catctttatg 1279801 tcctaaaaca ggccagcctg actttgcgac aatctacatc agctacattc ctgatgaaaa 1279861 aatggttgaa agcaaatcat taaagctgta tctattcagc ttcagaaacc atggtgactt 1279921 ccacgaggac tgcatgaata tcatcatgaa cgacttgatt gaattaatgg acccgcgcta 1279981 cattgaagta tggggcaaat tcacgccaag aggcggaatt tccattgatc cgtacacaaa 1280041 ctacggaaag cctggcacga agtatgagaa aatggccgaa taccgtatga tgaaccatga 1280101 tttgtatccg gagacaattg ataatcgtta attattccgt tgtgtgatac ggagtgtaaa 1280161 aggaagtgga gtcacagtaa aatccgaaca ttcagcgtta attttcagcg gaaatgtgac 1280221 ctggtcacag cgaagtgtga cccgcactaa gctcaataaa agtgggaaaa gtcacacctg 1280281 aaaatggctc tactcatggg aattgtatta aaaagtgtga cctgaggtgc aacctgaact 1280341 gtgactttta tgcagtgaaa aattgatagt acagaagcag attaaggcgt acaatttgta 1280401 cgtcttttct tttttatccg aaagaaaaaa tgcctatcta gagatcatag gcattaaata 1280461 ttattatcaa tatcttcatt tattttttgg ctaagtttct gaaccttctc tttaacattt 1280521 gaaacagctc ttttttgaat ttcatcaatt ctcctgaata tagtcgatga cacttcttat 1280581 tagaacttca ctttcaaaat tgaatatctc atttatttct gactgttctt catctgttag 1280641 gtgatggtat tgaagttgtt tagcatttac ttcagcagct acatcaatcc taacttagtt 1280701 gttctggttg tacaatttca tattcacctt ctgcatactc ttgctccgca taatagcctc 1280761 cccattgaca gagctcctgc aagataggtt taagagattc tccaagttca gtggatgaat 1280821 attcaacctt cggcggtact tgattataca tctttctgct cacaagtcca ctggcttcaa 1280881 gctctctaag tgtttgaatc agcattttct gagttatatt tgggataatg cgctttaatt 1280941 cactcgttct ctttggtcca ttcattaaaa agtataatac aaggcctttc cattttccgc 1281001 caataacttc ctttgtcact tcaaacccac agctaaattt tttcatgtct aaagctctcc 1281061 attccacatt tattactttt tagttactat atcacaaaaa agtgggtact tccgataatg 1281121 tgcttactga aggatactat atcttgtaag ttgttcttca agtacttaaa ggtactagac 1281181 ataaaataaa attaattcta aaggagtgtt aagtatgggt aaatttgaag gtaaaatagc 1281241 gcttgtaacg ggtggaacaa gtgggattgg tcttgctaca gcacaaaaat ttgtaaacga 1281301 aggtgcatat gtttatatta cgggacgtag acaaaacgaa cttgataaag ctgttaacca 1281361 aattggcaag aacgtaaccg gtgttcaagg tgatatttct aagcttgaag acttagacaa 1281421 actatatgac attataaagc aggaaaaagg taagttggac attctttttg ctaatgcagg 1281481 catcggcaac ttccttccat taggtgaaat tactgaagag caggttgata gaacgttcga 1281541 cattaacgtt aaaggaacca tctttactgt tcaaaaagcg ttatcactat tcccggacaa 1281601 agtaggttct attattgtaa cgggctctac tgctggatca attggcaacc cagcgtttag 1281661 tgtatatgga gcatctaaag cagcattaag agcactagtt cgcaactgga ttcttgacct 1281721 aaaaggtact gaaatccgtg taaatgtggt tagtccagga ggtattctta cacctgccta 1281781 cgatgagctt tttggtgatg cacttgaaga ggtactggaa aatagcagaa atactgttcc 1281841 agctggaaaa gttgggacac ctgaagaagt agcaaacgct gtatctttcc ttgcttcaga 1281901 cgaaagcagt tacttgacgg gtgttgaatt gttcgtagat ggcgggctag cacaggtata 1281961 atttcactgc gcagagatta caaatagtcc ccaaaaaagg ttaatgggga tttacttgaa 1282021 gaagtcgtat aaaaaagtcg ttttccttaa aggacaggga attcgacttt tttatatttg 1282081 aatttgatta acgttgtaaa ttcgcatttt cctggggcta ctactaaatg acctgtaaaa 1282141 aagattacac tgtgaataaa tgtacttaaa gtaacggggg ctcttgactt ttaataaaaa 1282201 ataatatccc tgtccttgta ttctaatact tttaaaaata tttaaaggaa tccttatgtc 1282261 ctgaataacc acataggaaa atatgttgta ggttgctttc tttttttgtg gggcatccca 1282321 cacaagctat ctcgtgatct cacacctgaa cgttttttat agactagtac cgcgacaagt 1282381 tatattacat atacatacca ataaagtaga cattaaaaag tgaaagagag gatggaaatg 1282441 tgtgaaaatt cttttccttg agagtcatcc catgtggctc tatggtttac cgaatgggtt 1282501 tagggaagca ggacataccg taatgatttc cggtcctgta agtcgggaaa atataactga 1282561 aatgatagac gaatttaaac cagatttaat agtatctatg ggatggacac cagagcattc 1282621 aagggaaaag caggcctgga ttcgcaacgc tactaaaaag gtgaatatcc ctctcgttta 1282681 ttgggcaact gaagacccgc tgcacactca aaactttact atcccgttaa ttaaaaagat 1282741 gaaaccggat tttgttttca cggtcacgcc ttctctgtgt aaaacttatg aaagcatggg 1282801 gattaaagca gctcacttag actttgcatt tcacgaaagt atacatcacc agattaaacc 1282861 attagcgaaa tacagttgtg atatagcagt ggtggctaat gcttacccta attttcttga 1282921 agaacatccg gaagtgttcc gttcgtcctc tttaaaaacg cttattcgtc ctcttatacg 1282981 gaagggtatt cgcattgatt tttgggggag aaactgggaa aaaatgagta aatatatagg 1283041 aagagaaatt ccccgcaatt ggatccatgg ataccttgat tatactgaag catataaagt 1283101 ttacagttca gcaaaaatca ttatcggttt gcaaaactgt gaaagccaac ttacacaacg 1283161 cacctatgag attcttggtt ccggggggtt tttattgaca tcggatacac cagcagttcg 1283221 aggtaaattc aaacctggcc gcgatctcat cgtttcttcc tccccaaaag aaacattgga 1283281 aaaggttaaa tactatttaa atcatgatag cgagagaaaa aagattcaga taaacggtaa 1283341 aaaggctgta aagaatgatt cctatcggca tagagccgag agaatgcttg aggtgctaaa 1283401 aagcagagga atcataagaa acttagggga aaccattcat tatgtagatg ttctcaaaga 1283461 aaaatacgtg atccatcatg ttactcccgg tgaaacatta tcaataattg ccagtaagta 1283521 taatgtttcc ctgcagcaac tcatggagct taatcatttc aaatcagatc aaatatatgc 1283581 tggacaaatc attaagatta gagagaaact gtttagaaat attaataaca aattattcta 1283641 aaggagagta atatgaatga aggggaaaat acctaaaata agaaatcaag cgaataaagt 1283701 aaaaagaacg cctcgttata tggaatttcc cgtgacatac gaagtatatc atgtggaatc 1283761 cggcgataca ttatggacga ttgccaaatc ctttgaaatt ccggtacaac aacttatgaa 1283821 tcttaataag ctttcttcag atagaattta tcctggacaa attataaaga taagagaaag 1283881 ataatctttg aggtttcgga agcgaatcaa attgaaatga caatcctcat ttttttattt 1283941 gtggggaact tgatattttt ggggatgaag gggttatgag atgtttcaaa tgagctatta 1284001 ctattctgga ttaggatggg actttattca acacgttgat caaacgaacg gagtattaaa 1284061 tgttgtgtct cctgattttt tctatatcag aaaagatgga tcattacttc tccgttcagc 1284121 taatcccgat gtgattaaag ctcttcatag aagaaaatta aaagtagttc cttttctaag 1284181 caatcattgg gatcaggatt tgggacgatt tgcattaatg aaccgagttc ttttagctaa 1284241 acaaatttct catgcaatag aagaactgga tttggatgga gttaatatcg atatagaaaa 1284301 ccttacagaa aaagatcgga atctatttac agattttatt agattagtaa ggaaaagtat 1284361 tcctagacat aaagaagtat cagttgcagt ggcggcaaat ccttttggct ggacgaaggg 1284421 ctggcacgga tcatatgatt acgagtattt agctaaatat gcagattatc ttatggttat 1284481 ggcctatgat gaaagccgcc ttgctgggcc tactgcaagt gtaggatggg tggaaaagtc 1284541 cattcaatat gttctgaccc aaaaaatctc tcctcaaaaa ctagttttag gattgccatt 1284601 ctatggccgc tgctggatgg aaggccaatc tgcctctcaa gccattcccc tttaccttgt 1284661 tgttagtaaa aaggcatagc gggacaatta tttttgacac caagagtcaa tctccaaaag 1284721 ctatttttac tgtcaatcac gataaaaagg ggccgttgcc ttcgggaaca tatacattat 1284781 ggtttgaaaa tgaacagtca ctcagagcaa aaataaaact cgctcaaaaa tataatctga 1284841 aaggtcttgg cagctggagt cttggacaag aagatgcgtc agtctggaat acagtgttta 1284901 aaaatatata atgatttata gttcagaaca aaattcgaag ataattgcaa tgaatctcta 1284961 aatggacata ctgaaaggag tttattacga gtgcgggtaa aacagtgagg gcattccata 1285021 ggcccttctc ccaaaatgtt ctacacgagg cattacattg ggcttgaaat acacattcaa 1285081 acttatgtta tagtacgcat tttacggatg tgttgaattt attctgcttc catgatttaa 1285141 tcatacacat gctacttgat agcagggtta tcgcatttca ttcagaattg ttcaggatcg 1285201 atatggaagc gcacgactaa ctagaacttt aaaagcatac actcatatac ttcctgaatg 1285261 gatgctggtt tatctaaaaa acatgatgag aattgattgt acgcatggtg aagcatgact 1285321 tgttgataat cgaccatatg gtttctcctt agaaatgagg gggtttttac ataaaaaaga 1285381 cgagcgaatc cggggggaat tccactcgcc gctttctaat gaaaagacgg gatgctggat 1285441 ggcagctcgt ctgttttatt ataatttaac gaacgtatgt ttgtaaaggt gtcttttcga 1285501 atgaattggt tcatataacc gttaagaaca gattcattgt aaacattcgc taaggtatgc 1285561 taagatgcat ggactataaa ggagtgatat gaagtgaaga cattgcggtt aaacaatgta 1285621 acgttagaaa tggctgcata tcaagaggag agcgagccga agcgaaaaat tgcatttacc 1285681 ttaaacgtta cgagtgagac ttaccatgat atcgctgtcc tgttgtatga aaaaacgttt 1285741 aatgtcgagg ttccggaacg cgatcttgcc ttccgggggg aaatgacaaa ttattcaaca 1285801 tcattgacca acctgtacga accaggggcc gtcagcgagt tctatataga aataacggaa 1285861 atagacaaaa acgccgattc atgatcggtg ttttttatgt aaaaaagctg ccggccggca 1285921 gcttttgaga aagcgaattt catatgtaag gtgttaaatt gtccgtcttg cagttttttg 1285981 aataaatgtg gaaataagga ggttttaata ggagtctctg atgatcttat aatttttatg 1286041 attaacaact gtcaatgaat ctaactcaag atcccgatag ttatccatga tcgtcacatc 1286101 aacgataaca gaattctcat ttactttttc aacaacaccg gttaatccgt ttttaaattc 1286161 aatgacattc ccaaccttag cgattttcac aagcttcctc tcctttaaac ataataatgc 1286221 cttttgaaag tattttgcag tattttcatt gagaagtaaa gcgataagga gttttatctc 1286281 ccttatgaat tgttctgtcg ctataaagat gatatattga ttttcgtcaa tagaaagaaa 1286341 aggggggaat ttttgttgcg tcccgaagaa ataacagaaa tgattgaaca gctgcgcacc 1286401 ggcgccataa acgaactgag agtccagaaa gagcattttc ttgatttcag ggccgtgtta 1286461 tctaaacaag atgattttaa acatttccga ggaattgccc agcaaggcgg agatgttatc 1286521 tttcaatact tagaacagcc aagaagctga aggtttctca tacgtgagaa gcctttttat 1286581 catatatgac agaacacaag ccttttatta cagctgtctg taacaggtgt aaataaaatg 1286641 taaagtacca aagatggata aacatgtttt aatttaacaa tatttataga atttcagact 1286701 gtttttttgc cattaagcag tgagtcatcc tctttattcc atcctgatac ctccttggga 1286761 gagttggaaa atctttttcc gtgaaaatga atggatctct tgttaaggtt atgaagtgtt 1286821 ttttggagca ctttaaggag gaaactgtat gacaacgaaa ttcactgctc tggctgtttt 1286881 tcttctttgt ttcatgcctg cagccaaaat tgagcataca caagcttcac tactgagcgc 1286941 aaagaagaca aaacatgaag aagcgaaatg gcttacacat atagatcgaa atacgaatga 1287001 atctttccct tcactgtctg ctgataaaga caagaaaata aaaccgatta agctatcagc 1287061 acacactgaa aagaaagaga aagataaacc ggacaaaaca aatgatgaga aagaaacata 1287121 tacacagtct gaaaaagagt tgctgtcccg tctcgttcac gcagaggcca aaggagaatc 1287181 atataaaggc aaggtcgctg tagcaagcgt tgtactgaac aggacggaga aaaaaggttt 1287241 tcctgatacg ataagaggag ttatttatca gaaaaacgcc tttgaaccgg tcgcaaacgg 1287301 gagcattaac caaaagcctg ataaagaatc gattgaagct gccgaagaag cgctgtcctc 1287361 aaaaaataga gaaacagatg ccatattctt ttataatccg aaaacagcgt cagataattg 1287421 gattcgttca agaaaaatcg tagaaaaaat cggcagacac gtttttgccg tctaagcata 1287481 gaagagacaa tttgtctcag ctgtgctttt tttcatataa agagtaaaaa taaaataatt 1287541 tttgaacttg tctcatatga tgttggtagt acaagagaca aggagagaca tcatgaatcg 1287601 atttgtgaaa gggatcattc ttttatccat tgccgccttt ttcgctgaat gccttgaatt 1287661 tgtcgtcaat atgattttgg cgcgggagct tggcgagcat gggatggggc tttacatgag 1287721 tattttgccc acgatctttt taattattgt catcgcgagc ctggaactgc cgatatccat 1287781 ttctaaattc attgccgagt caaatcctaa gcttcatgaa agcatgctga ggcacgcttt 1287841 cagaatgaca gccattttta ctgctttttc tactgccgcc gctagtattg cgcttccgtt 1287901 tattccggta tttgatacat accacccgtt tattaaaggg attgtcatcg gcttaattcc 1287961 tgttgtcgcc tttacttcaa tcgccagggg ctactttatg ggtgtgcaga aaatggggaa 1288021 gatcgcaatt gccaatgtgc tgaaaaaaat catccagctc ttgtgcttat tcctcttttt 1288081 tcaatggtac tcatttgaat tggacatggc tgtgctgatt tccttgtttg ttctagtcgt 1288141 gagtgatgtg gtcgtgcttg tttatttata ttcacaattt atcatggcaa ggcgggcgtt 1288201 atccggccag cagcacattc atttgcgcgg aaaggatgta aggaaaagac tgcttgctgt 1288261 ttcaattcct acaacaggac tgcgtatttt tcatgcggtt gtcaatgcaa ttgaaccctt 1288321 tttagtaaaa ggagctcttt tggctgcggg cgttgccggg acagcggcga tcgatcaata 1288381 cggaatgctg gcaggagtgg ctgtgacgat agggtcgttc cctgctttta ttgcccattc 1288441 gttaatggtc gtcatgatac cgagtatttc ggaagcttat gcactttctc agtatgacat 1288501 cgtgttaaaa aggctgaagc agtcgatttt cattacatta ggttacggta tacctgccgt 1288561 ctgggtcatg ttccagtttg cgggacctct cacgcatttg ttttttcact ctcctgaagc 1288621 gcagtattac ttgcagctgt tgtggcctta ctttctcttt catctgtttg tcatgccgct 1288681 gcaggcgtgc ttaatcggga tgggttttgt gaaagaggct ttttatcaca atgtatggag 1288741 ccatatcgtt gcgctaagta tgatgtatgt actgggatca atggagaatc tgcaaatgct 1288801 cgggattatc cttggaatga acactggcat gattcttttg acgagcctgc actatgccac 1288861 gatctgcaaa gcattgaagg tatctgtatt tcttacggga gggaccagaa cgccgcgaat 1288921 tgaaggatga taaaggaaca gcaggggcaa gctaattgaa aagcatgaaa ggaagattcc 1288981 atgttgacga agcgcttgct tactatatac attatgttat tagggttgat tgcatggttt 1289041 ccaggtgcgg cacaagctga ggaaaaacag cctgctgttc ccgctgtttt tcttatgaaa 1289101 acgatagaag gggaggacat ctcgattccg aataaagggc aaaaaacaat tctccatttt 1289161 tggacgtcat ggtgcccgcc ctgcaaaaag gagcttccac agtttcaatc gttttatgat 1289221 gcccatccat ccgacagtgt aaagctggta acggtgaatt tagtgaattc ggaacaaaat 1289281 cagcaagtcg ttgaagactt tattaaagca aacaagctga cgtttccgat tgtccttgac 1289341 tcaaaagggg aattgatgaa ggagtatcat atcatcacga tcccaacatc atttttgctg 1289401 aatgaaaagg gagaaattga aaaaacaaaa attggcccga tgacagcgga acaactgaag 1289461 gaatggacgg aagaatagct gagagcatag actctcagct tttttcatat agagaagaag 1289521 tgaataaaca ttaatgataa ttattatcaa aaagaaatta aaataattat aattgaaatt 1289581 ctcttcgtgc gtgctataat aaaggaagac atcaagaaat aactgacgat aaagctgcct 1289641 tttgggcagc gattttgttt ttataagaga aatgaagatg atttacgttc tcaattagag 1289701 aggagaattc gatatgaatg aacaagttat cgttcaacgc gacccgcatg agccattgaa 1289761 aacagacaag agggaaaaaa actgggcaca gcacgcggag cttattgcag cacttgtatc 1289821 aggcgctctt attttggcag gctggctctt atccggatat caggtattat ccataatact 1289881 tttcttgctg gcttttgtga tcggcggatt tgctaaagcg aaggaaggaa tcgaagaaac 1289941 actcgaatcc aaaacgctga atgtagaact tttaatgatt ttcgctgcca ttggttccgc 1290001 cttgatcgga tactgggcag agggtgctat tttaatattt attttttcct taagcggagc 1290061 tttagaaaca tacacgatga ataaaagcag cagagattta acgtctttaa tgcagcttga 1290121 gcctgaagaa gcgacattga tggtcaatgg tgaaaccaaa agagttccgg tttcagactt 1290181 gcaggccggt gatatgattg tgatcaaacc tggagaacgc gtagcggcag acggtatcat 1290241 tgaatcgggc tcgacaagtc ttgacgagtc ggctttaaca ggtgaatcaa tgcctgtaga 1290301 aaaaaacaca ggcgacactg tattcacagg aacggtgaat cgcaatggct ccttgacagt 1290361 ccgtgtcacg aaagcaaatg aagattcgtt attcagaaaa attatcaaac tggttgaatc 1290421 agcgcaaaat agtgtttcac ccgcgcaggc tttcatcgaa cgatttgaaa atgcttatgt 1290481 gaaaggtgtg ctaattgcgg tggcgctcct tttattcgtc ccgcactttg cgctgggctg 1290541 gagctggagt gaaaccttct accgcgcaat ggtgtttatg gttgtcgcgt caccttgtgc 1290601 gcttgtcgcc tctattatgc cggcggcgct gtccctgatt tcaaatggcg cccgcaacgg 1290661 tatgcttgtg aaaggaagcg tctttcttga acagctgggc tcagtgcaaa tgatcgcctt 1290721 tgataaaacc ggaactgtaa caaaaggcca gcctgccgta gagacgatca gaatagcaga 1290781 aggattcagt gaagcggaag ttcttgaggc tgtctatgcc atcgaaacgc aatcaagcca 1290841 tccgctcgcc caagccataa cggcgtacgc tgaaagccgc ggcgtgaatc agtccggcta 1290901 catatctata gaagaaacct cagggtttgg cgttatggca gaagtgtcgg gtgcgaaatg 1290961 gaaggtcggt aaagcaggtt ttatcggcga ggaaatggca gcacaattta tgaaacaaac 1291021 agcatcagat gtcattcaaa gcggtcatac aattgtattt gtgaaaaagg atgatcaaat 1291081 agcaggctgt atcgcactga aggaccaaat caggcctgaa gcaaaagagg tcatggaaga 1291141 actgaaccga cttgggatta aaacggccat gctgacagga gatcacgaag acacggctca 1291201 agcgattgcc aaggaagccg gcatgacaac tgtcgtggca gaatgcctgc ctgaccaaaa 1291261 agtgaatgaa atcaaacggt taaaagaaga attcggaacg attgcaatgg tgggtgacgg 1291321 aatcaatgat gcgccggcac tcaaagcagc ggatgtcggc attgcgatgg gcggcggaac 1291381 agatgtagca cttgagaccg ctgatatggt cctcatgaaa aacgatttga aaaagctcgt 1291441 aaacatgtgc cgcttgtctc ggaaaatgaa caggatcatc aaacaaaata tcgtgttttc 1291501 tctagctgta atctgcctgc tgatttgtgc aaactttttg caggcgatgg aattgccatt 1291561 tggcgtgatt ggtcatgagg gcagcacgat tttagtcata ctaaacggtt taagactcct 1291621 aaaataaaac cagcagccta atcaggctgc tggcttttta tgtatcaagc tttcccttca 1291681 tttttgtctt tatcagatct tttcataact aggatgagag cgagggtgca gcaaaggaaa 1291741 cccgctgcac agcctatgat agagctgtaa taataaaagc ccaccatctt catcccgata 1291801 aaaggagcgg aaattcccaa aaccgttaag agcataactg cttttcgtct gaaaaaattc 1291861 atcagcaaac ggaacaaccc ccctgcgatt gaacgttact gtcagtatac aggaagagga 1291921 gcaggaaata aaatgcatta gaaaatgaag gcgtcgtgaa aggcaaacac cggtaaaacc 1291981 tgttacaatg gaagacagaa caatgcattg caaatggcag ggaggaacaa gaagtgaata 1292041 gaatacaacg cgtctcttca tggctgaagg aagcggggca tactgccgca tttattcata 1292101 cgaaagaaaa tgttttttac ttaaccggtt tttacacaga gccgcatgaa agattaatgg 1292161 ggttatttat ttttcaagaa gaggagcctt tctttgtttg tccaggaatg gaagcaggac 1292221 aggcccgcaa cgcaggctgg aatcatgaaa tcattggcta tgcggatcac gaaaatccgt 1292281 gggagctgat agagaaggct ttgaaaaagc gaaatatcag catacatatg cttgcggtag 1292341 aaaaggattc aatctcgctg tcacgtgcag aacagctgaa gcatgcgacg ggcggggctc 1292401 aatttgtttc agcagaagaa acactcaatc aatttcgcct gattaaagat gacaatgaga 1292461 ttcgtttgct gaaagaggcg gcaaagcttg cagattacgg tgttgaagtc ggcacagccg 1292521 ctttgcgtga aggcatcagt gaagtggaag tgctcgctca aattgagtat gagctgaaga 1292581 aaaaaggaat tcagggcatg tctttctcta caatggtttt attcggagaa aaatctggcc 1292641 agcctcatgg aaatcctggt acagccacgt tgaagaaagg tgattttgtt ttatttgatc 1292701 tcggtgttat tcttgatggc tattgctctg atattacaag aacgtttgca tacaaaacca 1292761 tcaatccgaa gcaggaggcc atttacgaga ctgtgcttca agcggaaaaa gccgcgattg 1292821 aggcaagcaa acccggtgtg agaatcggag atctggattt aactgcccgc ggaatcattg 1292881 aaaaagcggg atatggtgat tattttcctc accggcttgg gcatggactc ggaatttcag 1292941 tccatgagta tccatcaatg agccaggcca acgatacact gctgcaggaa ggcatggtct 1293001 acacgatcga accggggatt tatgtgccag agatcggcgg cgtacgcatt gaggatgacg 1293061 ttcacgtaac aaaggacgga gcagttgctc tgacccaata tccaaaggat ttgatcatac 1293121 tgtaatagaa ataaaaaagg actttgttct cgacatcgtc cttttttatc tgcattaaat 1293181 aaaaaaatca tcaaatgttc gaaagggttt aatttcatgt ttttggttga gaggttttac 1293241 agcaagacag ctgccaccga gaacagtgag acataaccca attaaaatga agaaacccat 1293301 gtgatcttct cctttcagct aaaaacacaa aaagatatct ggtacgtcca tatcatattg 1293361 tatgaaacgc attccagatc aaggggattt agaaagaagg gaatctatgg ctaatattaa 1293421 agacattgca gagaaagccg gtgtctctgt tacaacggtt tcccgagtca taaacaatca 1293481 tccatacgtc agtgaagaca aacgaaaaag agtgtttgag gcaatggaat cattggagta 1293541 cacgagaaat attcacgctg tacatttgtc gaaaggattt tcaaacatga ttggtgttgt 1293601 cttgccgacg gttaatctgc catattttgc agagctgatt gcaggaatag ccgacgcagc 1293661 cgcggaatcc ggggttcacc tctctttatt ccaaacaaac tatgaagtac aaaaagaaat 1293721 ctttgcgctg tcccaattaa agcagcgcca ggttgacggc ctgatttttt gctcaaaggc 1293781 gcttgctgat gagaaactca tggaatggga gggcccgatt ttgctttgcc agaattcaga 1293841 taatgcccgc ttcccaacca tcagcattcc tcaccaagaa gcatttcgga acggcttgga 1293901 ctatttaatt gccaaagggc acaaaaaaat agccatctgt ttggcaagaa aaaaaggcat 1293961 gaacagccat tttcgaatca aagcctacaa agaggcattg gaagagatcg gcgaggcatt 1294021 tcgtgaagac tgggtaattg agaaagcgat tacaatcaat gatgggaagg cgctttttca 1294081 taaatggaat acgtggaagg aaaagccgac ggctattttt gttgccaatg accaagtctc 1294141 agcagggctt tttcttgaag caaagaacca gcgggtgtca gtaccggatg agcttgcaat 1294201 cttaagcgtt gataaccacg aaatcagcca agcgcttgga atcacaacga tcgatattca 1294261 gacaagggaa atgggaaagc aggcatttgc catattggaa aaaagaattc aaggacagcc 1294321 gattgaaagg aaagttctgg attaccgtct catcgaaaga tcgactgttt agtgaatgca 1294381 ttgaaaaaag gtttgacgtg cattctgttc gttatgtacg atatgaggta ttgaatgaca 1294441 aaggagctga ggatcgtgaa tgggtccttc acagtgaaaa aggtactgaa taataacgta 1294501 ttaattgctt ctcatcataa atacagcgaa gtcgttttaa tcggaaaagg tattggtttc 1294561 ggaaaaaaac aagatgatgt cattgaagat aaaggctacg ataaaatgtt cattttaaaa 1294621 gacgagaagg aacaaaagca gtttaaaaag ctccttgact atgttgatga aaagctcgtt 1294681 gatatttcaa acgatgtcat ctatcacata agcaatagga cgaatcactc attaaatgaa 1294741 catattcaca ttgcgttgac agaccatatc gcatttgcga tcaaaaggca gcagcaggga 1294801 tttgatatga aaaatccatt tctaatggag actcagtcac tatatcctga ggagtaccaa 1294861 attgccaaag aagtcataga tatgatcaat gaaaaagcgg gactctgcct tccggaaggg 1294921 gagattggtt ttatcgctct gcatatccat tcagcgttga caaaccgtcc gctgtccgag 1294981 gtcaatcagc actctcagct catggcgcag cttgtcgagg tgattgaaga ctcatttcaa 1295041 atgaaagtaa ataaggaaag tgtcaactat ttgcggctga tcaggcatat cagatttaca 1295101 atagaaagaa ttaaaaaaga agaaccgact aaagaaccag aaaaattaat gttgttattg 1295161 aaaaatgaat atccgctatg ctacaataca gcttggaaat tgattaaaat cttgcagcaa 1295221 acattgaaga aaccagttca tgaggcggaa gcggtttatc tgacgcttca tctgtaccga 1295281 ttaaccaata aaatttcata aattcagttt atccttataa cgtgttactg attcgatcag 1295341 gcatgagtga ttgagggaaa aaaacgggaa gttcattctc gttcttttgc gcacccaatt 1295401 ttgctcatgc ctttttgttg tgtaaaaggg caaatgtaaa cggttaaact ggaagactta 1295461 cgcctgtgaa ttcgttgtca tgatttttag ctgtaaggtc agactagtaa aaagaggagg 1295521 tcaattctta tgtttaaagc attattcggc gttcttcaaa aaattgggcg tgcgcttatg 1295581 cttccagttg cgatccttcc ggctgcgggt attttgcttg cgatcgggaa tgcgatgcaa 1295641 aataaggaca tgattcaggt cctgcatttc ttgagcaatg acaatgttca gcttgtagca 1295701 ggtgtgatgg aaagtgctgg gcagattgtt ttcgataacc ttccgcttct tttcgcagta 1295761 ggtgtagcca tcgggcttgc caatggtgat ggagttgcag ggattgcagc aattatcggt 1295821 tatcttgtaa tgaatgtatc catgagtgcg gttcttcttg caaacggaac cattccttcg 1295881 gattcagttg aaagagccaa gttctttacg gaaaaccatc ctgcatatgt aaacatgctt 1295941 ggtataccta ccttggcgac aggggtgttc ggcggtatta tcgtcggtgt gttagctgca 1296001 ttattgttta acagatttta cacaattgaa ctgccgcaat accttggttt ctttgcgggt 1296061 aaacgtttcg ttccaattgt tacgtcaatt tctgcactga ttctgggtct tattatgtta 1296121 gtgatctggc ctccaatcca gcatggattg aatgcctttt caacaggatt agtggaagcg 1296181 aatccaaccc ttgctgcatt tatcttcggg gtgattgaac gttcgcttat cccattcgga 1296241 ttgcaccata ttttctattc accgttctgg tatgaattct tcagctataa gagtgcagca 1296301 ggagaaatca tccgcgggga tcagcgtatc tttatggcgc agattaaaga cggcgtacag 1296361 ttaacggcag gtacgttcat gacaggtaaa tatccattta tgatgttcgg tctgcctgct 1296421 gcggcgcttg ccatttatca tgaagcaaaa ccgcaaaaca aaaaactcgt tgcaggtatt 1296481 atgggttcag cggccttgac atctttctta acggggatca cagagccatt ggaattttct 1296541 ttcttattcg ttgctccagt cctgtttgcg attcactgtt tgtttgcggg actttcattc 1296601 atggtcatgc agctgttgaa tgttaagatt ggtatgacat tctccggcgg tttaattgac 1296661 tacttcctat tcggtatttt accaaaccgg acggcatggt ggcttgtcat ccctgtcggc 1296721 ttagggttag cggtcattta ctactttgga ttccgatttg ccatccgcaa atttaatctg 1296781 aaaacacctg gacgcgagga tgctgcggaa gaaacagcag cacctgggaa aacaggtgaa 1296841 gcaggagatc ttccttatga gattctgcag gcaatgggtg accaggaaaa catcaaacac 1296901 cttgatgctt gtatcactcg tctgcgtgtg actgtaaacg atcagaaaaa ggttgataaa 1296961 gaccgtctga aacagcttgg cgcttccgga gtgctggaag tcggcaacaa cattcaggct 1297021 attttcggac cgcgttctga cgggttaaaa acacaaatgc aagacattat tgcgggacgc 1297081 aagcctagac ctgagccgaa aacatctgct caagaggaag taggccagca ggttgaggaa 1297141 gtgattgcag aaccgctgca aaatgaaatc ggcgaggaag ttttcgtttc tccgattacc 1297201 ggggaaattc acccaattac ggatgttcct gaccaagtct tctcagggaa aatgatgggt 1297261 gacggttttg cgattctccc ttctgaagga attgtcgtat caccggttcg cggaaaaatt 1297321 ctcaatgtgt tcccgacaaa acatgcgatc ggcctgcaat ccgacggcgg aagagaaatt 1297381 ttaatccact ttggtattga taccgtcagc ctgaagggcg aaggatttac gtctttcgta 1297441 tcagaaggag accgcgttga gcctggacaa aaacttcttg aagttgatct ggatgcagtc 1297501 aaaccgaatg taccatctct catgacaccg attgtattta caaaccttgc tgaaggagaa 1297561 acagtcagca ttaaagcaag cggttcagtc aacagagaac aagaagatat tgtgaagatt 1297621 gaaaaataag ggtgttagta cgccgtgctt gtcagatgac aagtacggtt gtatgatata 1297681 atattgtgaa gtaataaagc tttaagttaa aaggagaatg ataaaaatgg cacaaaaaac 1297741 atttaaagta actgcagatt ctggaatcca tgctcgtcct gcgacagttc ttgtacaaac 1297801 tgctagcaaa tacgacgctg acgttaattt agaatataac ggcaaaacag ttaaccttaa 1297861 atctattatg ggtgttatgt ctttaggtat cgctaaaggc gctgagatca caatctctgc 1297921 ttccggagct gacgaaaacg atgctcttaa cgctttagaa gaaacaatga aaagcgaagg 1297981 actcggcgag taatgcaaga attaaaaggg attggtgctt cagccggcat cgcgattgca 1298041 aaagcgtacc ggcttgaaga gccagattta acggttgaaa agaaaaacat ctctgattct 1298101 gaagcggaag taagccgttt tgatgaagcg attgcacgtt caaaagaaga gctcgaaaaa 1298161 atcaaagagc acgctttgaa agaactgggt caggataaag ctgatatttt ttctgctcac 1298221 cttttagttc tcagtgaccc tgagcttctg aaccctgtga aagaaaaaat cagcactgat 1298281 tcagtgaacg ctgaattcgc tttaaaagaa acgtcttcta tgttcgttac tatgtttgaa 1298341 tctatggaca acgaatatat gaaagagcgt gcggcagata tccgcgatgt aacaaaacgc 1298401 gtaaccggcc acctgcttgg cgtcgaaatt ccaaacccaa gcatgatctc agaagaggtt 1298461 attattgtag ctgaagactt aacaccgtct gacacagctc aattaaaccg tgagttcgta 1298521 aaaggattca ctactgatat cggcggacgc acatctcact ctgccatcat ggcacgttct 1298581 cttgagattc cagcagttgt tggaacgaaa gctgctacag gcacgatcca aaacggcgtg 1298641 actgttatcg ttgacggtat caatggcgat gtcattattg acccatctgc ggaaactgta 1298701 aaagagtatg aagaaaaaca taatgcttat ttggctcaaa aagctgagtg ggcgaagctt 1298761 gtcaatgaac cgactgtctc aaaagacgga catcatgtag agcttgcagc gaacatcggt 1298821 actcctgatg atgtaaaagg tgttcttgaa aacggcggag aagcagttgg cctttaccgt 1298881 acagaattcc tttacatggg aagagatcag ctgcctacag aagatgagca gtttgatgct 1298941 tacaaaacgg ttcttgagcg tatggaagga aaatcagtcg tcgtgcggac acttgatatc 1299001 ggcggagaca aagagcttcc ttacctgcag cttcctaaag aaatgaaccc gttcctggga 1299061 tatagagcga ttcgtctttg ccttgaagag caagaaatct tcagaacaca gcttcgcgcg 1299121 ctgcttcgtg caagtacata cggaaacttg aaaatcatgt tccctatgat tgcgacagtt 1299181 aacgaattca aagaagcaaa agcgatcctt cttgaagaga aagaaaagct cgtaaaagcg 1299241 ggacaggctg tatctgacga tattgaagtc ggaatgatgg ttgagattcc gtcaactgca 1299301 gtcatcgctg atcagtttgc taaagaggtt gatttcttca gtatcggaac aaacgatttg 1299361 attcaataca caatggcagc tgaccgtatg aatgaacgtg tatcttacct gtatcagcca 1299421 tacaacccgg caatccttcg cttaattaca ctggtaattg aagcagcaca caaagaagga 1299481 aaatgggttg gcatgtgcgg agaaatggca ggagacgaga ttgcgattcc gatccttctc 1299541 ggcttaggct tagatgagtt ctcaatgagc gcaacgtcta tccttccggc aagaacacaa 1299601 atcagcaaat tgtctaaaca agaagctgag tcattcaaag agaaaatctt atctatgagc 1299661 acgacagaag aagttgtcgc gttcgtaaaa gaaacattca agtaatgtac aaaaaccaga 1299721 cggcctccgg cctgtctggt ttttttcata agtaagggta tagaaggaca caataacatg 1299781 gctaggaggg atagtatgtc aaaccaattt aacgcaggag atactgttta tgtgatctac 1299841 agaaatccgc acgccgccaa tgtagcccac ataaaggaag ccgaaattgt gcaccatcca 1299901 taccatgaag gcgagctttc cctgtttatt tatgaaacct atcatccatt cgcagaggac 1299961 gatgctgtgt ttgcaagcta tgaagaagct aaatcgcttt acaaagaact gtttgatatt 1300021 gatccgtatg agtaacaagg aaatcattac aactcatatc ctttccgcct agtgagaaaa 1300081 gtaacgttag taaaggaaaa ggatgtggca tcatgcagaa cccatttgtt ccgcagcttg 1300141 tgtatataga accgagggcg ctggaatatc cgctgggcca agaattacaa gataaatttg 1300201 agaatatggg tattgaaatc agagaaacga catcccacaa tcaggtgcgt aatatccctg 1300261 ggaaaaatca tcttcagcaa tatcgcaatg cgaaatcaac tttagttatc ggtgtccgga 1300321 aaacattaaa gtttgattca tccaaaccct cggccgaata tgccattccg tttgcaacag 1300381 gctgcatggg gcattgtcat tactgctacc tgcaaacaac catgggatca aagccgtata 1300441 tcagaactta tgtaaacgtc gaagagattt tagatcaggc agataagtat atgaaggagc 1300501 gcgcaccaga gttcacaagg ttcgaagcat catgtacgtc agacattgta ggaattgatc 1300561 atctgacaca cacgctgaag cgcgccattg aacattttgg ccaaagtgat ctcggaaagc 1300621 tccgatttgt aacgaaattt catcatgtcg atcacctatt agacgcaaag cataacggga 1300681 aaacgagatt cagattcagt attaatgccg actatgtgat taaaaacttt gagccgggaa 1300741 cttcacctct tgataagcgg atagaagcgg cagtaaaagt tgcaaaagca ggctacccgc 1300801 taggctttat tgttgctccg atttatattc atgaaggctg ggaagaagga tacagacatc 1300861 tgtttgaaaa gctagatgct gctttgccgc aggacgttag acatgacatt acgtttgaat 1300921 taattcaaca ccgttttaca aaaccggcca aacgagtgat agagaaaaat tatccgaaga 1300981 cgaagctcga attagatgaa gaaaagcgcc gttataaatg gggccgttac gggatcggaa 1301041 aatatattta tcagaaagat gaagagcatg cacttcgaga ggcacttgaa tcctatattg 1301101 ataccttttt ccctaacgca aaaattgaat atttcactta aacgggctgt tgtgatcaac 1301161 agctcgcttt tttataaaaa acatttttcc attccatcaa aacgccgtaa ttcaatgatt 1301221 ctttatcctc caaataattg ctgactacac gaataggtga acgcccgcaa cggaggagaa 1301281 aggacagcac agggtcgttt ttcctgcctt ccatcacatc ttcaacgtac tgaacagcgc 1301341 tgatctcgtg tgcgtattta taatacaaag gaatgcggcc gccgccgaga aggcgttcca 1301401 gtcttttatc aacagtcagc tcatacatcg tattcatcag ccattttccg attccaagct 1301461 ttcgataatg aggagaaaca gaaatatcca ctacatataa agtatttcca tgaggttcat 1301521 gatttttaat cgatccgttg tcagttgctt gtgcccatgt atgatcagga gaatcaggct 1301581 caaattgtac aataagagca gtcatggaac cgataattct gccattgatg agcgcgcata 1301641 aagcgccttc cggaaaggtt ttgatatggc tggcaagctg gtcctctgac cacagcaatt 1301701 cctggggaaa cggaggaggg aaacattctt cttgaagaga aatcagcctc tcgatgtcag 1301761 tctcagtgta gtttctaatg gtcagagcct caaattttct gccgtcatgc acatacattt 1301821 gttttagtat gatcatcact ctccttatgt tgtttcatta taacgaagat tgaattttca 1301881 gtaaatatat tccgattttc ttataattta ttttttgatt attcattttt caaacgaaag 1301941 ggccgatata gaaattagga ggggattggt ttgtttaaaa aacttcacat gaagattgct 1302001 gtttttgttt cgattatgtt aatcatcaca gttgttctct taatgctgtc ttcttatttg 1302061 acgctaaaac cgatgattac agaggatggg aaaaatacaa ctcaaaacgt gacgcagtca 1302121 cttgaacaaa atattgaatt gcaattaaag agttatgcca tttcgttatc aagattggct 1302181 aatggggaat taacgcatac atttgtaacg aaaccaagta aagaagcttc tcggctgttt 1302241 cacgatgaca ttaagcaaat caaagacaac gatgattatg ttgcgatggc ttacataggc 1302301 accgcaaaaa aagaaatgtt tacatatcca aaagcggatt tcgctgagga ttacgatcca 1302361 acatcaagac catggtataa gcttgcagct gaaaccccgg atcaagttgt ttggacggaa 1302421 ccttataaag atgtcgtgac aggagacatg attgttactg catcgaaagc gatcttagac 1302481 aggcaaaaag tgataggggt tgccagctat gacttgaaac tctctgctat ccagagtatg 1302541 gtcaataaac aaaaggtgcc ttacaaagga tttgcctttt tagctgatgc gagcggcaat 1302601 cttttagccc atccgtcaaa tcaaggaaaa aatatatcaa aggatcaaac actgcaaacc 1302661 atcgcatccg agaaaaaagg gatacaagat gtgaatggga aaatggttgt gtaccaaacg 1302721 attggcgaga caggctggaa ggtcggaacg caatttgata ccgatcaatt aatgtggatt 1302781 tcagataaaa tgaatcgggc caatctttgg atatcattga ttgcgcttat cataacaatt 1302841 attctcagct acttcctggc caaaacgata accggtccga tacagcagct gatcgtaaaa 1302901 acgaaagctg tttccgcagg cgatttaaca gtgcgcgcgg aatcaaaatc taaggatgaa 1302961 gtcggtattt taacaagaga tttcaatctg atggttgaaa atatgaagga aatggttgag 1303021 caagtgagac tctcttcagg gaaagtatct gacacctctg aacaactaac ggctgtggct 1303081 gccgaaacta atgaaacaag cggacaaatt gcaaaagcga ttgaagaagt agccgcaggg 1303141 gcatcggaac aggcttctga agttgaaacc attaatgaaa aatcggaaag cctgtcaacg 1303201 aaaatcaggc aaatcgctga ggaggcaggc ggaattaaag aacgctcaaa atcgtccgag 1303261 gatgcaagct ataaaggact tgacgcgctc ggccagctgc tgatgaaatc aaacgaagcc 1303321 aatatggaaa cgaaaaaggt tgaaacgatg ctgctggatt tggaaaatca aactaagaat 1303381 attgaagaag tcgttacagc gatttcaaac atatctgatc aaaccaactt gcttgcctta 1303441 aatgccagta ttgaggcagc cagagccgga gaaagcgggc gcggttttgc cgtcgtagcc 1303501 gatgaagtgc ggaagttagc tgagcaatca gccctttcta caaagcatat cagcgagact 1303561 gtgaagctta tccagcttga gacaaaagag gcctctcacg cgatggttga ggcaagcaga 1303621 atgaatgatg aacaaaacag tgcaattcac gaaactggag aggtattaaa tacgataact 1303681 gcagaaatgc agtcactggt acaaggtatt gatcacattt acgcggaaat tcaaagaatg 1303741 agtgaagaac agcttgcgat ttctgaagcc attcaaagca tttcagccat atcacaggaa 1303801 tcagctgccg cagcagagga agtgaacgca tcaaccgatg aacagcttgt cacccttgat 1303861 aaagtcaaac actcaacgga aacactaaaa catgcaagcc aagagcttat gaacacaatt 1303921 gcaaaattca cattgtaatc caattacatc cccaaacatc atttgttttg gggatttttt 1303981 attttataag atgaatagat atggtagtct agaaaatgaa ggaaaaatga taaattttaa 1304041 ctaaaatcta aacgaaacat ctgggaggaa tgaccttgaa aaaaacaatt ggttttatcg 1304101 gtcttggagt aatgggaaaa agcatggcat cacatattct caatgacggc catcctgtat 1304161 tggtgtacac ccggacaaaa gaaaaagcag aaagcatact tcaaaaaggc gcgatctgga 1304221 aagatacggt caaagatctt tcgaaagaag cggatgttat catcacaatg gtcggctatc 1304281 ccagtgatgt tgaagaagtg tatttcggaa gcaatggaat tattgaaaac gcaaaagaag 1304341 gtgcatatct tattgatatg acgacatcta agccttcgct tgcgaagaag attgctgaag 1304401 cggccaaaga aaaagcattg ttcgctttag acgctcctgt ttccggtgga gacatcggtg 1304461 cacaaaacgg aacactcgcg attatggtcg gtggagaaaa agaagctttt gaagcctgca 1304521 tgccgatttt ctctttaatg ggagagaata ttcagtatca aggaccggct ggaagcggac 1304581 agcataccaa gatgtgcaat cagattgcaa ttgcagccgg tatgatcggt gttgctgaag 1304641 cgatggctta tgcccaaaaa tcaggcctag agccggaaaa tgttctgaaa agcatcacaa 1304701 cgggcgcagc cggaagctgg tcattgtcaa atcttgctcc ccgtatgctg caaggcaact 1304761 ttgaaccggg attttatgtg aagcatttta ttaaggatat gggaattgca ctagaggaag 1304821 cagaattaat gggggaagaa atgccaggct tgtcgctcgc aaaatcttta tatgacaagc 1304881 tagctgctca aggtgaagaa aacagcggaa cacagagtat atataagctt tgggtgaaat 1304941 aaaaaaagat tgcctgtacg aaacaggcaa tcttttttta ttattttccg atgaattgtt 1305001 gtgtccagat gcttccagac tcaacgtaac caacaccgat gtgagtaaag ttagggttta 1305061 gaatgttttt tctgtgtcct tcactgttca tccaagcttt tactacttct tctggtgtct 1305121 tttggccctt cgcaatgttt tcacctgctg ttttgtagct gattccgaaa gatttcatca 1305181 tatcaaacgg tgagccgtat gttgggcttt ggtgatcaaa gtagtttttg tctttcatat 1305241 cctgagattt tgcgcgtgca gatttgctta acgtttcatc aatttgaagc ggttttaagc 1305301 cttgtttttg tctttctgca tttgtaagtt caacaacttt tttctcatat gcacttacag 1305361 atgaaggtgc agacgttgtt gtgtttgttt tttcagcagt tgcgggtgct ttagaagcag 1305421 tgttttgatc agcagctgct ttttcagtag tcttttgtgc aggttttgcc gtttctgtct 1305481 tttgaacatc ctgaactttc acgttagatt gcttcgcatg tttttgaaga agctgcttca 1305541 tctctttttc gtttgcagcg tttaacgttt tgatatttgt gttaatatgc agttttttca 1305601 ctgcatcgtt aagtgacatg ttttgtactg tgttccccgt ttttactgta accacaggct 1305661 ggcaggagag ttctttcgct gatgcttgct gtacgccccc gaatgtgaat aatccaaccg 1305721 cagcggcagc agataaaata aatgctttct tcattagttc gtaacctcct agagttgttt 1305781 gtttctacag aaaaatcata acatagcttt tttgtcataa agattccagc actttccttt 1305841 gacaaataga gattgtcatt ttcgtaaagt aaatccgttg aatcactaag aataagggaa 1305901 tcagcggtat atatgatttt atcgtaccgt tacatagctt cctttttttt gaaccgttag 1305961 ttatatttta atgtgttttt atattgacag ctttttttac tccttttcgc tgtaacaact 1306021 attacaaagg tgttacaatt aatctcagta tatgtaaata tattgaatga tttgagaggg 1306081 gtaaccagaa gtgactgaaa taggacgtga accaaagaaa aagagcaaag gaaacagagc 1306141 aatcagaatg aacctttttt tcctagctgt ctttgttcta ttcactgcat taatttttaa 1306201 gctcggggtt gttcaaattg ttgaaggcga acagcatgaa gaagacgctg agaaatcaaa 1306261 tgcaaaaaca gcttactatc ctgcgcctcg cgggaagatg tacgacagaa accagaaagt 1306321 tgctgtcgac aaccagagcg ttccagaaat tgtgtatgta tcaacatcta gcacaaaaac 1306381 agaagataaa atcaaaacag cgaagcggct tgcttctttc attcatattg ataccgaatt 1306441 tttgaaggaa agggatcttc gtgattactg gatcgcagct catccgaaaa aagccgccgc 1306501 tctgcttaag gaatcagaaa gcaatctgaa aggagaccag gcttacaagc ttcaaataga 1306561 gcgtgttccg gatcaagaat taaaggctat tcagcaagat gacgaagaaa tggaaactgc 1306621 tgcgatatat acaaggtttt caagcggaaa tgcttacgaa cctcaaatcg taaaggcaat 1306681 gaatccaaat aagagcaata gcaatggaaa aaacggagcg ctgcttgatg agaagaaaaa 1306741 ctcctcgcaa agaccaaaaa atgacttaac atatgatgaa atttccattg tttctgagca 1306801 tttagaagaa cttccgggaa tcgatatcgt aaacgattgg acacgaaaat atccttatga 1306861 caaaaccctt tattctgttt tcgggggcgt cacgacacct gatcagggcc tgctgagcga 1306921 ccggaaagat ttctacttaa caagaggcta tgcgaataat gacagggtgg gaaaaagtta 1306981 tttagagtat caatatgaag aatatttaaa ttcgcataaa gaaaaagtgg aatacgtaga 1307041 agataataaa ggaaatgtcg tcagccaaaa aaccattgat aagggcagca ggggatacga 1307101 tcttcagctt tcttttgaca tggagcttca ggcaaaggta gaaaagatca ttgaagaaga 1307161 agtaagaaac agccgtgcac gcggaaatta catgcttgac agagcctttg ccgtaatgat 1307221 ggacccgaat aacggcgata ttttatcaat ggcagggaaa aagatagatt taaaaaccaa 1307281 caaaattgaa gattatgcga taggggcatt taccacccaa tatgaaatgg gatcagcagt 1307341 aaagggggcc accgtgctag ccggctatca ggacgggatc ccgcattata aatattatat 1307401 cgatgctcca atgcttttag gaacgaatct tataaaaaaa tcttatacta atatgggaac 1307461 catcaatgaa ttaaccgcat tgcaaaaaag ttcaaacgta tatatgttca atgttgccat 1307521 gcatattgca ggcgtaacat acaagccgca tggatctctc ccggctgatc agaacgatct 1307581 actgaaaatg agaaactatt acagccagtt tggtctggga gtaaagacag gtattgatct 1307641 cccgcaggaa tcagccggaa tgcaaaccac acctaaaact gtaggaggat taattttaga 1307701 cttagcaatt ggccaatacg atacatacac accgcttcaa atggctcaat acatctcagt 1307761 aatcgccaat ggtggctatc gtgttcagcc tagaatcgtc acaagtattc ataagccagg 1307821 aaaaaaagac cagctgggta aggcgattga acataggaaa cctaaagtac tcaataagat 1307881 taataattca gagagcgatt tgaaacaagt acaaacaggc atgaaattag tcacttcttc 1307941 agggacagca aaaaatacgt ttacagaaga tgtatcaggg aaaacgggaa cagcggaaac 1308001 attttactac ggcacgaatc gcaactggtg ggggaaaaaa acatacaatc tgacttttgt 1308061 cggctattac ccgtcgaaaa aaccaaaagt ggcctttagt gttgttgttc catcagtaga 1308121 tgatgatgat aagatcaata aaattattgc caaaagagct atccacgcct acgcagagct 1308181 cgaaaaaaaa cacagtaaaa aataaaaaac agggtgcaca actaaaagat tgtgtgccct 1308241 ttcttttatt caaaaattga cgttcaccat aagaatagaa ggagaatact cattttctag 1308301 cgaatcatac taggtaaaag tcaatctgta tatgtcgaaa cacgatgatc atgcaaagga 1308361 gggattctgt ggaacaggat acgcagcatg ttaaaccact tcaaacaaaa accgatattc 1308421 atgcagtctt ggcctctaat ggacgcatca tttatatatc tgccaactcc aaactgcatt 1308481 tgggctatct ccaaggagag atgatcggat cattcctcaa aacgtttctg catgaggaag 1308541 accaattttt ggttgaaagc tatttttata atgaacatca tctgatgccg tgcacctttc 1308601 gttttattaa aaaagatcat acgattgtgt gggtggaggc tgcggtagaa attgttacga 1308661 caagagctga gcggacagaa cgggaaatca ttttgaaaat gaaggttctt gaagaagaaa 1308721 caggccatca atccctaaac tgcgaaaaac atgaaatcga acctgcaagc ccggaatcga 1308781 ctacatatat aacggatgat tatgaacggt tggttgaaaa tctcccgagt ccgctatgca 1308841 tcagtgtcaa aggcaagatc gtctatgtaa acagcgcgat gctttcaatg ctgggagcca 1308901 aaagcaagga tgctattatt ggtaaatcgt cctatgaatt tattgaagaa gaatatcatg 1308961 atatcgtgaa aaacaggatt atacgaatgc aaaaaggaat ggaagtcgga atgattgaac 1309021 agacgtggaa aaggcttgat ggcacacctg ttcatttaga agtgaaagca tccccgaccg 1309081 tctacaaaaa ccagcaggct gagctgctgc tgctgatcga tatctcttca aggaaaaaat 1309141 tccaaaccat cctgcaaaaa agccgtgaac gatatcagct gctgattcaa aattccattg 1309201 ataccattgc ggtgattcac aatggaaaat gggtatttat gaatgaatcg ggaatttccc 1309261 tgtttgaagc ggctacatat gaggatttaa ttggcaaaaa catatacgat cagctgcatc 1309321 cttgcgatca cgaggatgta aaagagagaa tccaaaacat tgccgagcaa aaaacagaat 1309381 ctgaaattgt caagcaatcc tggttcacct ttcagaacag ggtcatctat acggagatgg 1309441 tctgcattcc gacgaccttt tttggtgaag cggccgtcca ggtcattctt cgggacatct 1309501 cagagagaaa acaaacagaa gaattgatgc tgaaatcgga aaaattatca atcgcagggc 1309561 agctcgcggc gggaatcgcc catgagatcc gcaaccctct tacagcgatc aaaggatttt 1309621 tacagctgat gaaaccgaca atggaaggca acgaacatta ctttgatatt gtgttttctg 1309681 aactcagccg tatcgaatta atactcagtg aactgctcat gctggcgaaa cctcagcaaa 1309741 atgctgtcaa agaatatttg aacttgaaaa aattaattgg tgaggtttca gccctgttag 1309801 aaacgcaggc gaatttaaat ggcattttta tcagaacaag ttatgaaaaa gacagcattt 1309861 atataaacgg ggatcaaaac caattaaagc aggtattcat taatttaatc aaaaatgcag 1309921 ttgaatcaat gcctgatggg ggaacagtag acattatcat aaccgaagat gagcattctg 1309981 ttcatgttac tgtcaaagac gaaggggaag gtatacctga aaaggtacta aaccggattg 1310041 gagagccatt tttaacaaca aaagaaaaag gtacggggct tggattaatg gtgacattta 1310101 atatcattga aaaccatcag ggagttatac atgtggacag ccatcctgaa aaaggcacag 1310161 cgtttaaaat ttcatttcca aaaaaataaa aacaacggct taaacgccgt tgtttatcgt 1310221 ctgcattgct tcacgttttt ttaatacaaa taattctaaa cggtctaggc cttctctcag 1310281 cgtgtccatt gagcatgcaa aagacagcct tacatatcct tcaccatatg ttgagaacga 1310341 gctgcccggc acgagtgcca cgccagcgtc ttccaaaaga gccatactaa aatcaaatga 1310401 agtcattcca aatgatttaa tagaagggaa gatataaaac gcaccggacg gtttaactac 1310461 gtcaagtccc atggaaacaa gacggtcata aacatagtcc agacgttttt tgtattgttc 1310521 tctcataatc aatgcatcgt caaagccgtt tgtgacagct tcaagcgcgg ctttttgaga 1310581 aatggatgag gcgcacgaca cattgtattg atgaaccttt aaaatgtgct ttgcaatgtc 1310641 tttcggtgca aataaaaatc caattctcca accggtcatg ctgtgtgatt ttgacaaccc 1310701 gttaatgaca atcgtttgat cccgcaaata ggttgcgatg gagtaatgcg gtctgtcata 1310761 tgttaattca ctgtatattt catcagacaa tacgaagaca tttctgcctt ttaagagagc 1310821 tgcgatgctt ttcagttctt cttcagataa agtcacgccg gtagggtttg acggataagg 1310881 aagcacgaca cacttggtgt tgggtgtcag agcatcttca atcagccggg cggtaagctt 1310941 aaagccgtgt gacgtagtat caacaatgac aggcttggcc ccgcacaaat tgataatagg 1311001 ttcatagccc ggataaatag gccctggcat aatgacttca tcaccgggag ataaaatcgt 1311061 ccggaatgca gcatcaatgg cttggcttgc gcctgttgtg atgataattt cagattcagc 1311121 atcatagttg aaatccgctt ttttcttcat ataaagctgc acagcttgtc tcagctccag 1311181 gtagccggca ttcggagtat atgacgtcac gttttcatca atggcttttt ttgcggcagc 1311241 tttcacatga tgcggtgtga aaaaatcagg ctggccgatt gtaagtgaaa tgacgtcttc 1311301 gtgttgggct acaagattcg agaatttgcg tattcctgaa atttcgatct ctcttgcttt 1311361 cggattcagc aaatgttcca taattcatca ccttaacaaa tataatgagt ttatcctatt 1311421 ttaccactag ctgatcattt gtcacctttt taactgatat atttcgattg tatgcgcctt 1311481 ttttctaaac atacctttct tttcagaaaa aaagaagaca accagcgatt tgattgtctt 1311541 tattgtatca tgttctatta ttgtttatat gtgccaattt cattaatagc cataatcaaa 1311601 atgaaggtct tcgtgccaaa tcagatacgg aggatgctct tcttgaaggt cagctgattc 1311661 tttcttcata ttcaggtaag tttcttcact gatatcctct aaaacagtca tttcgttttc 1311721 tttaaatatt actaaggtac ccattattta cacccttctt tggaaaaatc cttgactatt 1311781 ttatcactgt tagttggaaa gtcaatggtt attaggaaaa aagtttcttt tttgaggaac 1311841 gcggcttgtt gccttcggaa ttcgattttg aagagctgcc attcactttt tacaaattac 1311901 gccgatatat acagtacaat actgaatgcg aatagcgagg gattgaattg tcgttacaac 1311961 aatacgaaat tttattggat tctggtacaa atgaattaga aattgtgaag tttggcgtgg 1312021 gtgaaaatgc tttcggaatt aacgtcatga aggtaagaga aattattcag cctgtcgagg 1312081 tgacatcagt gcctcactcc catcagcatg tagaaggaat gattaaactc agaggagaaa 1312141 tcctccctgt gatcagtctc ttctcatttt ttggagtaga gcctgaagga tcaaaagatg 1312201 agaaatatat cgtgactgaa tttaataaac ggaaaattgt ttttcatgtc ggctctgttt 1312261 ctcaaattca cagagtatcc tgggaagcga ttgaaaagcc gacatcgtta aatcaaggaa 1312321 tggagcggca ccttaccggt attattaagc tcgaagacct gatgatcttt ttgcctgact 1312381 atgaaaaaat tatttatgac attgaatcag attcaggtgt tgacacgtat aatatgcata 1312441 ccgagggctt cgatgaaaga agaactgata aaaagcttat cattgtagag gactcaccgc 1312501 ttttgatgcg cctcttgcag gatgaattaa aagaagcagg gtacaacaat atcgcttcgt 1312561 ttgaaaatgg aaaagaggca tatgaataca ttatgaacct tgctgaaaac gaaactgatt 1312621 tatcaaaaca gattgatatg atcatcactg atattgaaat gccaaaaatg gacggacaca 1312681 ggctcacaaa gctgctgaag gaaaatccga aaagctcaga tgtgccggtt atgattttct 1312741 catcgttaat tacggatgat ctgcgtcacc gcggcgaagt tgtaggcgca gatgagcaaa 1312801 tcagcaagcc tgagatcagt gatttgatta aaaaagtgga tacgtatgtt attgaataaa 1312861 taaaaacagc cgttgccaga aagaggcacg gctgttttta ttttaaaagt aactctcgcc 1312921 aagtttttta aagaccggtt tatggtaagc tggctgctgg cgatttggca ctagcggctt 1312981 ttctttcatg ccgacatatt cttgcaatag gtgtttcgct tttgttaaag acatttgagc 1313041 tttaggattt cgatacgatt gattaagtgt acctaaatgc ggaagatgtt cgaagtcttc 1313101 tttagttgga ggcatgtgaa aatagtagtc tccgattgag ataagcacgt ccgattgctg 1313161 ttggctgaac cttggatttt ttgaaaaatg aagccctatt ttctttcctt taccttcttt 1313221 gacaagcttt tgcaaagccc gttttttcag cagatatagg tatttagggt tgggggcggt 1313281 ttttgcatgg cggttcacag tgtaaactgc ttttgaaaga ttttctacgg ttggctgcag 1313341 atctttcgta tatgcatggt cgtccattat ttctctcctt tgctcttatc aatttctata 1313401 tgtttagatt atactttttt aaagttgaaa tgcaaatatt gaatgtaaaa atgcgctttt 1313461 ttctaagaaa aaaagcgcat ttttaacctg cattatacag atcttgcctt ctttttcggc 1313521 tgttcttgaa atgcttcctg aacattcact tccacagcct gagcactgta ttttggcagt 1313581 gcaataaaat aaaaaataaa aacgagcagg ataataacac ccatgccgta ataaagataa 1313641 tcaatgtttg aaacaaactt agggaataac agcgcgacta agccgagtgt caaagattgt 1313701 gcaaacatca taaaagggtc ctgcatgccg cttacacgtc ccatcagttt tggatgaaca 1313761 atttttggca tccaccctcc gattgcaatg ttgatcggtc cgatacacat tcccagtgca 1313821 aaagctgccg cgtaatacac ccataaaata ttggtgtagc cgaggacgaa gatcagcaaa 1313881 cctgcaatga aaatcggtat cgacattaaa aagtgcggct tcactttttt agagatgagc 1313941 gtgccgatta cgcttcctgc cagaagccca aacccgagtg cgatcgtaaa tacagacgta 1314001 tgccactcat aacggtcagg cgccaatcca tatttcattg taaacatcgg caatacggcg 1314061 aatcctccat tgacaaatcc aaaaatgaag aagccaaaaa taagagatgc cagcaatttg 1314121 ttttttaaaa tatagaggat gccttctcta aagtcattta ttgaatcctt aacagaagtc 1314181 tttctccagc tgaatgcacc gtttggctgt cgggcttctt ttggaatccg gcagctgcgg 1314241 atcagcagcc cggaaatgat aaagctgaca aaatcaagaa taatggcgcc ttcaataccg 1314301 attgtgttgt acataaacgc gcctatgccg actccaaaca ccataaaaat gctaaaaagc 1314361 atctgattaa gccctgccgc tttcgcataa tgctccttcg gcagaatggc ttgtaccaaa 1314421 ctgttttctg ccggaaagaa aaactttgtt acagcgcttc tgataaataa gatacaaaaa 1314481 acaagaggaa tattgccggt aaataaagtg aaaaaaagca cgacagtcag gcctgctctg 1314541 atccaatcac aattttctgc cacctttttt ctatcaaacc ggtccgcgac gactcccacg 1314601 atcagaaata caaatatggt cggaagagaa tacatcagct ccgccaaggt cgtatatgaa 1314661 ggctggctgc tgaatcggtc cagcaaaaaa aaagcaaagg ccatgttgcc tactgtcgtg 1314721 cccatttgag aagcgagtgc tgcgaaaaat agacgaacaa aattacgatt tttaaatata 1314781 tccataaaaa cgctccttac cctaaaggtc ccactttatc atattataaa ccgcctgttt 1314841 ttgaaacaaa taagaaaaca ttaccggtta atcgtgactc tcgttccgtt tggcacaatt 1314901 gaagcaagtt cgatcacgtc tttgttatgc atgcgaatgc agcctttaga aacagcctta 1314961 ccaatcgaag cgggattatt cgtcccatgt attccgtagt gctgctttga aaggctcagc 1315021 caataagcgc caaatgggcc gccgggattg cgctggcggt taataatgta aaactcgcca 1315081 gtaggcgttt gcgttagtat tttaccaacg gcgatgggat aggttttcat tacccgatta 1315141 tttagggaca gcgtaagggt cttcgctccg attgagactg cgatatgata cggaattgta 1315201 taagggtccg gcagtccggg gatgactatg gactgtcccg cggtgagccc tgcctgcagt 1315261 gacggattag cctggagtaa tgcagccgtg ctgattctga aatcagccgc gatgctgttc 1315321 agtgtatcac cttgcttcac ctggtacgta agcagtttcc tcatcctcct tttttactta 1315381 taagtattga tgaggagccc atcctgctac attaatttgt gctttttaag gtgaagacag 1315441 tgatttcagg cttggcaaga aaccgcaaag gcagcctggt catcccgagg cctcggttta 1315501 cgtaaatatg agtgctgccc gtttgataca ttccctctgt gtagactttt ccatatggag 1315561 gcgtaataat cggtccgtaa aaaggcagct gaatctggcc gccgtgtgta tggccggaaa 1315621 gctgaaggtt cacgggataa tctgttgttt tcaaggctgc atcaggttca tggacgagaa 1315681 gaatggaaaa aagtctgtcg ctcagccttg aaagggtgcc ttcataatct gggtttccca 1315741 gcattaagtc atcaagcgaa gcaatctcga ttttgctgcc atctgcgagt gacaatgttt 1315801 gatagccatt gcgatatacc gtgaaacctc cggccgtcat caggcttttg taaacggcag 1315861 ttccatagcc tccgtgatca tgattgccgt aaatacaaag cttgccgaag ggagcattaa 1315921 gctttctcaa taatggaatg actgcctggt ggtgctggta cgtatcagga ttatcaataa 1315981 tatcacctgt aaaaacaatg agatcaggtt tagattcatt aattgtaaga atgacagttt 1316041 ttaaatcttc gagagtaaag taatcactca agtgtgcatc gctgaactgc acgattttaa 1316101 aaccgtcaaa tccgtgcggg atgagagagc tttttattgt gtgttcggtt gtctcgatca 1316161 tatgcggctc gagatacctg gcatagccat atcccccgcc ggccgttaaa gccccggcag 1316221 caagagcgcc gaacattcct tttagaaatt gtcttctgga catctttttc atttcaaacc 1316281 aacctttaat agagtttttc tattatatca tctgtatctg ataaaaatct catatgagca 1316341 tgtgctgaca gaggcaggga tataatgata gaatattatt gaatgaataa tcattcacaa 1316401 ttggagggat aaacatggaa aaaaaggcgg taattattac cggcgggtca agcggcatgg 1316461 gaaaagcgat ggcaaaaaaa caggctgaat tagggtggca cgttatggtg acagggagga 1316521 accatgaggc acttgaggaa acaaaaaaag aaattcagac ctttgaggga caggtcgctt 1316581 gttttcaaat ggatgtccgt tccgattccg ccgcttcaga catgattaaa gaagcggtaa 1316641 aagcctttgg ccggcttgac gcgctgatta acaacgcggc cggaaacttt atttgtccgg 1316701 cagaaaagct gacgcccaat ggatggaaag ccgttattga gattgtttta aacggcacat 1316761 ttttttgcag ccaagcagcg gcaaggcatt ggattgacca gaagcagcag ggtgtcattt 1316821 taaatatggc agccacgtac gcttggggag cgggagcggg ggtcgttcat tccgctgcag 1316881 ccaaagcggg ggtattgtca ttgacaagaa cgctggccgt tgaatggggg agcaaatacg 1316941 gcattcgtac aaacgcgata gcccccggac cgattgaacg aacaggcggt gcggagaagc 1317001 tatttgaatc ggaaaaagcg atggcccgca cgatgaacag tgtgccgctc ggccgattgg 1317061 gcacaccgga ggaaatcgcc gctttggcag cgtttttgct ttctgatgaa gcatcctata 1317121 taaacgggga ttgtatcaca atggacgggg ggcaatggct gaatccttat ccgttttaat 1317181 ctgaatattt ataagtgaat atttaagtta ttaagaactt ttatgttcga atgtaatacc 1317241 tccacaatta accttcttcc tatccaattt gataacacat agagctttat ttgtttatga 1317301 ggtgttgtgt catacgtaag ccacctaata tatgaaaggt atattttaaa aggggagacg 1317361 aaatatgaag aacttagatt tcaaataaaa cattcatata attacttcgt taactaaaaa 1317421 gagaaattat aagaatgaaa ggtttcaagg ttacatcaga ttgggaggaa ggtaatataa 1317481 tggacgagat ggtattatta actcaggaat ggctcaatga aacgtacaaa ggaaaaagtg 1317541 gctacaattc cattgaggaa aatgggaaaa ctggctggaa aacaatgtat gcattaacta 1317601 gagcattaca actagaattg ggaattacac agacttccga cagttttggt cctacaactt 1317661 taagaaagct taaagaatta ggcccgattt ctacgtcaac taattcaaaa aaaaatattg 1317721 tgaaaattat tcaaggtgct ctttattgta aaggttatgg tccaggtgga ttaacgggta 1317781 catttggtca gggaacgaaa gaggcgatag cagaaatgca attgcatatg gggctttcta 1317841 aaacagacgg tgtagtaacg cctaaggtgt ttaaagcttt attaaacatg gactcttata 1317901 tccttttaaa tggggcgtca gagaaagttc gttcaataca gcaatggcta aataataaat 1317961 attacaatag agagaatttc tactttatgc cctgtgatgg cctgtattca agggatactc 1318021 aaaagtctct tgtttatgca atacagtacg aggaagggtt aagtgatagt atagctaatg 1318081 ggaattttgg accaactact caaagattga ttcctgtatt aagaattgga gaaacagatg 1318141 aaaaaaacag ttttattcat ttatttcaag ctgctctaat ctttaatggc tacaatgttc 1318201 cttttgatgg agtatactct gaatctgtaa gatcaaaagt aaaggctttt cagtcttttg 1318261 caaaattaca acagagtggt actgccgact ttcaaacatg ggcttcactt ctagtaagta 1318321 ctggagaccc caatcgaaaa ggagttgctt gtgactcaat tactcaaatt acatcggaca 1318381 gggcggagtc ccttaagagg gcaggttata agattgtagg gcggtatcta acaaatgcgc 1318441 cggggagtac actaaataaa aaaatacaac caggtgaatt agaaactatc ttaaaatcag 1318501 gtttaaatgt ttttccgatt tatcaaacct atgggggagc aacaaattat tttaataaag 1318561 aacaaggaaa gaaagatgcg tttgctgctt ataaagcagc aaaagaatac gggtttaaaa 1318621 ataacactgt aatatacttt gcagtagatt atgatgcata tggtaacgat ttaaacaaca 1318681 atattattcc acacttcgaa ggtataaatg aaataatgaa cggtttttta ggttcaactt 1318741 acaaaattgg tatttatgcc cctaggaatg tatgtactat agtttctaaa aaaggtttag 1318801 catttgcaag ttttgtaagt ggtatgtcta ctggctttag cggaaactta ggatatcctt 1318861 tgccttacaa ttgggcgttt gaccaaattt caacaattac tgttggaaat ggttctggaa 1318921 tgattgaaat tgataatgat atttgttcag gtttggataa tggagttaat accataaata 1318981 tagtgccttc agagaataag aagttttttg atcaaattga tgttttatat gaaactgctg 1319041 aaaaatatgc tcaaatgcaa agcgacttaa ataatggggt aaaaaaaaca caattagcta 1319101 atgagttggt tgcccagtat ttaagaaagg atgactacaa agggtggaag tgggtcccta 1319161 ccgcaggcca gattgatcct atttatcgtg aatgggcagt aaagcgctag gggaagacct 1319221 agtaaatgga attgttgatc ctatatcaaa aactgtcata ggaacgcagc atcttatggc 1319281 aacttataat gccattattt atagtggtgg ttactctcaa acactacgag attttgctgg 1319341 ttggactgga gatctattaa caacaataca ggacatgaaa ttacacgctc aagaatttaa 1319401 ttcgccttat gatgcggcta tgaaaataat aggtaatatg tatcaattta gcctagatga 1319461 tttatttagt gatgtagatg caattaatct agcgaataaa acatcagttg gtgctaatgc 1319521 acaacctcta aatatcgcaa ttagagatta ttatagtaat aatgactgta tgaataggtt 1319581 cactcaattt gtaaataata gatttgatgg ttcgttagac aaaattttct ctgaagcaga 1319641 gtattattta aatacaaacc ttgacccagt tgttgttcca attaggttag cctttaaacg 1319701 tgcttttgat gttgaggatt atagtgaaga gattggaaaa ataacagcac aagcatttag 1319761 agatgttatc gagaaaaaaa tgatatctga ataaactgca aaacaagcga acgttaaaac 1319821 tggtcgttcg cttgttttat tttctattta aatttatgat ataattttta aagattaagg 1319881 agtgattcat tgaagaaatt gttaaaaaag ttagttgtat tatttttaag cagtttagtt 1319941 atcatcttta atgtttggta ctttattatt tgtgcttttt ccccagagta ttatcaaaat 1320001 acaaatctta cttctaatga aataataaga tttgaaaaac tataccacat agattttcct 1320061 gatgaaacaa aatttattaa agctagagag tatttggctg ggcccggagg agatacgtca 1320121 gctgtattat atgtgtctct gccaaccaag cgggtagaaa aagttttatc tgattacacg 1320181 tatatgaaaa taaactatac tgacaatgtc ggttcaatgt atggagttga cgtttcaaag 1320241 agtgtcgccg gtttaacaac tcttacattt ggcacttacg ataaaaaagg aactttctat 1320301 aatatgaaac atgatgatga ttggatgtat aaaggcactg actggaatct ttacttttgg 1320361 acagctgcta gttataatgc tgttattttt gtatttgttt tggttattgt gaaacaaatg 1320421 aataaaattc ttaattaacc agtatgtaga ttgataatct caaaaaaatt ttcctcttct 1320481 tttaacatac tccatacgac ctacttttcc atactatgat ttttttgaaa tttgtggtgt 1320541 agttataatt gtgcgtataa tcagacaaag atagagaagc aggtgataac atgttggatc 1320601 cacttgatat tttaacgaac attgatgatg tccttccata ttaccaggcg atttttagtg 1320661 ccgaggagca gaaggttgtc ggatatgagg tgcttggacg aattttggca gattcagaaa 1320721 tccaaagtct cgggcccttc tttttagatg cggggatacc cgaagaatat aaattagagg 1320781 ttgataacag aattatccgc caggctcttg accgcttttt agaggcggat tctgatctgc 1320841 tgatttttat gaatcaggat gccaatctgc tgatgctgga tcatggtgaa agctttctgg 1320901 agcttctgaa agaatatgaa gcgaagggaa tcgaactcca ccgttttgtg cttgaaatta 1320961 cagagcacaa ttttgaaggg gatattgagc agctctacca tatgcttgca tactatcgta 1321021 catacggaat taaaatcgca gttgacaaca tcggaaaaga aagcagcaac ttggacagaa 1321081 tcgcgctgct ctcaccagat ctgttaaaaa tcgatttgca ggcgctgaaa gtgtcacagc 1321141 cgtcaccgtc atatgagcat gtgctgtaca gcatatcttt attagcaaga aaaatcggtg 1321201 cggcgctgct gtatgaagac attgaggcga acttccagct tcagtacgcc tggagaaacg 1321261 gaggccgcta ttttcagggc tattacttag tgtctccatc tgaaacgttt ctagagagag 1321321 atgtattgaa acaaagactt aaaactgaat ttcaccaatt tatcacacat gagaaaaaga 1321381 aactggagac cgtctatgag cactctgaac agttttacaa acgagtgcat caggctgtga 1321441 cctctttgag aaaaaacaat ctgtcttctg atgatgactt tattaaaaag ctggcggaag 1321501 agctgacaga ttgcagcttc aggatttaca tgtgtgatga agaaggcgat cagctgacgg 1321561 gaaatgtgtt taagcaagat ggagaatgga tttatcagcc ggaatatgcg gaaaagaact 1321621 ggagctggcg cccttatttt ctggagaaca ttatgagaat gagaaatctc agaaaaggtt 1321681 ttttcagtga tctgtacagt gatttggaaa caggtgaaat gatcagaacg ttttcatatc 1321741 cgatggatga tcagatgtat ttatttatag acttgcctta ttcttattta tatgagcagg 1321801 acggactgat ttaacggctg aaaggccgtt ttttttatga aatgaaaaaa atatcaaaaa 1321861 acgattgaca ttgatactga gaatcattat catttaatta tagagagaag ctactctctg 1321921 ttccccaacc cctctatcag atcaagatcc gaaaaaactt ggcgctaccc ccgccaagtt 1321981 ttttatttgt caaagcatag gacaatccaa tgaaacaata aacctaacta gtggtaaacg 1322041 tttaacacgg ggagaaacat tgagtgccga acacccctga cactgctgca cgggtgagga 1322101 ggaaaattcg ttctgaaatg attatttcag ttccgttgtt tacctctatc cagcatgact 1322161 cccattgatt atggccacgc gggacttcac cataaaattc aaaagaaggt tttgacaaag 1322221 ttgcaaaaag gcattcttaa tgctgccaaa gattcgaaaa aaattataat tatgtgcatg 1322281 acattcaaaa aaagcctcaa actaaagaaa aatagttttt ttcacttttt ttctttgctt 1322341 aaattcagca gtgaaaatgc catcctgtcc gactttatgg tatgatgctc aatagaactt 1322401 gtattataat aaatacttgt tgatttgaag ttgctttttg aaaggagtct ttttttagaa 1322461 tgtcacaatt aatgggtatc atcacacggc tgcaaagtct gcaagaaaca gcggaagcgg 1322521 ctaacgagcc aatgcagcgt tatttcgaag tgaatggtga gaaaatatgc agtgttaaat 1322581 atttcgaaaa aaatcaaacg tttgaactga cggttttcca aaagggtgaa aaacctaaca 1322641 catatccgtt tgataatatc gacatggttt ccatcgaaat ctttgaactt cttcagtaag 1322701 attcctgaaa tagggggaac aagcttccgc ctttgcaaaa gtaatcgaaa taaacggtaa 1322761 ggaacatact tgtttcatgg ttgtaaatcc ttgaaaagga gtgtcgtgat ggctgattct 1322821 tttctgtttt ataatctttc agaagcacag atgacctttc aagatgtgat ggaacggctt 1322881 aaagcctttg ttcaaaagga cccccgttct tcttatgtgt tatcgatcgg aaccgattca 1322941 caggtttacc gcgattacac aaagtttatt accgcattgc atttgcatcg tacaggcaag 1323001 ggagcttggg gctgcttgaa aaatcataca gtcgacagac ccatacatag ccttcgggag 1323061 aagatttcgt tagaaacggc gtacagccaa gaaacggccg ctcatattct tgatggacac 1323121 ttaatggata ttaccgatct gctcctgccc tttaccggtg agggggcgga tcttaccttt 1323181 gaagttcact tggatattgg gaaaaaaggg cttacaaaag atctgatcca agaaatgact 1323241 ggacgtatta cctccatggg gattgaggcc aaaataaagc cggattcata cactgccttc 1323301 agctatgcaa atcgtttcac aaaataattt ggctgaaaaa gccaaggtaa atgtcgaatt 1323361 atgcggttga cgtttgttat ctgattactt attctagcgg tagagctgaa agtaagttgt 1323421 cttgctttca gaggtattca gtataaaaca gggggcctga ttgcgaatga gtcttatcgg 1323481 tgaacgattt acagaagaag aacaaaaact tctgctgaat atcctgatca accatgagta 1323541 tgccatcgag ctattaagca gtgagatcaa cgatatagag acagggacca aaaacgttga 1323601 cggaaccacc tacaaaaaac ttgtaacgct atacgaccga tttcgatttg aaaattaatg 1323661 ggacacccta taattgatac tccacaaaga gtatcttttt tattgaaagg aaacttttcg 1323721 acaaatactg ataaagttta tattattgca atatagggaa tgtattgatg atgaaaatga 1323781 aaaggggtcg aaaacatgat aagcttacaa tcagatcaac ttcttgaggc aacagtcgga 1323841 caatttatga ttgaggcgga caaagtagcg cacgtgcaag tcggaaataa ccttgagcat 1323901 gcattattag tattgacaaa aaccggatac acagccatcc cggttctgga tccttcctac 1323961 cgtttacatg gcttaatcgg gacaaatatg atcatgaaca gtatttttgg acttgagcga 1324021 attgagtttg aaaagcttga ccaaatcact gttgaggaag tcatgctgac cgacattccg 1324081 cgccttcata tcaatgatcc gattatgaag ggattcggca tggtcattaa taacggattt 1324141 gtctgtgttg aaaatgacga gcaggtattt gaagggattt ttacgagaag agtcgtttta 1324201 aaggaattga ataagcatat acgctcattg aataagtagg ctgtacggtc ctatttttat 1324261 tatataggca gagtgaaaaa agaaagcgca tacataattt aaacgagaat agggcttgaa 1324321 taagaaacta agattttatt agaatgggag ataagaaaaa cttattgata acaaaaagga 1324381 ggacgacatg cagcttcaag agcttcatat gctcgtagtt ttagctgagg aattaaatat 1324441 gagaaaggcg gcagaacggc tttttgtatc tcagccggct ttatctcagc gcttacaaac 1324501 cattgaaaag gcgtggggaa caaaaatctt tttaagatct caaaaaggat taacggtaac 1324561 gcccgccggt gagaaaatca ttcagtttgc gaatgatgtg acattagagc aggaaagaat 1324621 aagagaaaat attgacgagc ttgaaggtga aattcacggc acattgaagc ttgccgtcgc 1324681 ctccataatc ggtcagcatt ggctccctaa agtcctgaag acgtatgtgg aaaagtatcc 1324741 gaatgcaaag atctcgctca taaccgggtg gagcagcgaa atgctgaaaa gcttgtatga 1324801 ggatcaggtt catatcggca ttataagagg caaccctgag tggaaggggc gcaaagatta 1324861 cttaatgaca gatcatctgt atttagtgga tactgaaatt tcctgcatcg aagatattgc 1324921 ccatacagaa cgtccgttta tccagtttaa aagtgacagc acttattttc aggaaattca 1324981 gcactggtgg catcaaaaat ttaaaacgtc gccgaaacag acgatattgg ttgatcagat 1325041 tgaaacgtgc aaacagatgg cgctgcacgg aatcggttat gccattttgc cgtctgttac 1325101 ccttcaaaat gaagataaag tgaataaaat gcctctttta gacatgaaag ggcatccgat 1325161 cggtcgggat acatggttat taggttatga gcctgccttt gaactgaaac aagttcaagc 1325221 ttttgtacaa gtgataaagg atatgctgga tcaggaaaat ccattttaaa gacagcgagg 1325281 tgctgtcttt tttttattta tctgttgaca atgaaaatca ttatcattta aagtgataca 1325341 tatgatattg aaaatcatta tcaactaatg gggtgataac atggctaaag ccttgattac 1325401 atatgccagc atgtcaggaa atacagaaga cattgccttc ataataaaag atacgcttca 1325461 ggaatatgag ttggatatcg attgtgtcga gataaatgat atggatgcgt cttgtttaac 1325521 ctcctatgat tatgtactga ttggcaccta tacatggggg gacggcgatt tgccctacga 1325581 agcggaggat tttttcgaag aggtcaaaca gattcagctt aatggtttaa aaacagcctg 1325641 cttcgggtct ggcgattatt cttatccaaa gttttgcgaa gcggtgaatt tgttcaatgt 1325701 catgctgcaa gaggcgggag ctgctgttta ccaggaaaca ctaaaaattg aattagcgcc 1325761 tgaaacagat gaagatgtgg aaagctgccg agcgtttgcg agaggttttc ttgcatgggc 1325821 agattatatg aacaaggaaa aaatccatgt ttcataaagg ggcaaccgct gttacggcat 1325881 cggcgttttc tggatatttt gtggcggtac aaagagaagg catttttcat tactctttgg 1325941 agcagggctg gagaaagctt tttcgtttga aaagtaagat acactgtatc agctacatag 1326001 ggccttactt atttggcgtt ggtgaaaagg gaacagtcat tcgttcggct gatgaaggga 1326061 aaacctggac gatgtcgagc tttccgacaa atgcaacagt gtgggcgatt accggcagaa 1326121 acaacgggtt tgtctgcgcc cacggtaagc attgtattta tgtatcggat gattttggtg 1326181 tctcatggcg cgtagccaaa ccttttgccg aatttcataa tccccctgtt atccggtcgt 1326241 tatgccttca cgggggcaat ctctttatcg gcacgcaaat acacgaatat tttggcggca 1326301 tttgggctta cgacattaag cgtgacactg tccaagttgt caaaaaagaa aaaaaccgga 1326361 tgacggcatc catgctcgtg ttcaatgaaa attggctggt ggcggcgatg ggttctgtga 1326421 aaggaaagca cggtgctgtc actgtaagga atcttttgaa tggtgaagaa ttcaccatac 1326481 aatccagtat gatcagaaat gaagaatcat ttcttgatct ttcagaggat gatggcatta 1326541 tatatgtcac tacaacacaa gatgaaaatg gtttttcgag aatttaccag gttgatctcg 1326601 aagcccggtc gttaaaatgg ttcgatacca ttaagggaca tggatggaga gtggccaatc 1326661 agaaagagaa tttcttttgc gcaggcttgt atgaatgtaa atttgtccag ccgtacgaag 1326721 tttcagcaat gattcattag aggaggaaca aggaattggc gaagattttg ctcgtttatg 1326781 caacaatgtc aggcaacact gaagctatgg cagatttgat tgaaaagggg cttcaggagg 1326841 cgttagcaga agtagaccgt ttcgaagcaa tggatattga tgatgcccag ctgtttaccg 1326901 attatgacca tgtcataatg ggaacctaca cgtggggaga cggagatctg cctgatgaat 1326961 ttttagatct tgttgaagac atggaggaga ttgatttttc cggcaaaaca tgcgctgtat 1327021 tcggttccgg tgatacagca tatgaatttt tctgcggagc ggttgatacg ctagaggcaa 1327081 aaataaaaga acgcggtgga gacattgtgc tgccttcggt aaaaatcgaa aataatccag 1327141 aaggtgaaga agaggaagaa ttaataaact tcgggagaca attcgcaaag aaaagcgggt 1327201 gcgctgtctg atcactcact gggaactgct aaaacggctg ttcctttttt tcttgtcttt 1327261 gtatctttcc tttgatacag taatgaggta gaaaatcagg aggaggacta tacatatgaa 1327321 aatgatggac gcaaatgaaa ttatttcatt tattcaaaat agtacaaaat ctacacctgt 1327381 aaaggtttac gtgaaaggtg agctggaagg aatcaatttc ggtgaatctg cgaaagcttt 1327441 tatcaatgga aacactggtg tcgttttcgg tgaatggagc gaaatccaaa cagcaatcga 1327501 agaaaaccaa agcaaaatcg aagactatgt ggttgaaaat gaccgccgca attctgcgat 1327561 cccaatgctt gatcttaaaa acatcaaagc gcgtatcgag ccgggtgcga tcatccgcga 1327621 ccaagttgaa atcggtgata acgcagtcat catgatgggt gcttctatta atatcggttc 1327681 agtcatcggc gaaggcacaa tgattgatat gaacgttgtg cttggcggac gagctactgt 1327741 tggaaaaaac tgccatatcg gcgcgggttc tgtacttgcg ggcgttattg agccgccatc 1327801 cgctaaaccg gttgtgattg aagacgacgt cgtaatcggc gcaaatgctg ttgtgcttga 1327861 aggtgtaaca gtaggtaaag gagctgttgt tgctgcggga gcgatcgtgg taaacgacgt 1327921 tgagccatac actgtcgttg caggcacacc agctaaaaaa atcaaagaca ttgatgaaaa 1327981 aacaaaaggc aaaactgaaa tcaagcagga attacgccag ctgtaaggaa aagtttgata 1328041 aaaaaggcgt ggataatata tccacgcctt attcgtatag gcaggaggaa tagaaatgaa 1328101 gatagaggag ctcatcgcaa ttcgcagaga tctgcatcgt ataccggagc ttggatttca 1328161 ggagttcaaa acccagcagt atttattaaa tgtcttggaa caatatccgc aagacagaat 1328221 tgaaattgag aaatggcgaa cagggctttt tgtaaaagtg aacgggacgg cgccggaaaa 1328281 aatgctggca tacagagcgg atatcgatgc gctttctata gaagagcaaa ctggtcttcc 1328341 attcgcatca gagcatcacg gcaacatgca cgcctgcggt cacgatttgc atatgacaat 1328401 tgcactcggc attattgatc attttgttca ccacccagtc aaacatgatt tgctttttct 1328461 gtttcagccg gcagaggaag ggcctggcgg tgcggaacca atgcttgaga gcgatgtatt 1328521 aaaaaaatgg cagcctgatt tcatcactgc ccttcatatt gctccagagc ttccggtagg 1328581 caccattgcg acaaaaagcg gccttctatt tgcgaataca tcagagctag tcatcgatct 1328641 ggaaggcaaa gggggacatg cggcatatcc gcatttggct gaggatatgg ttgtagcagc 1328701 aagtacactt gtcacccagc tgcaaacgat tatctctaga aacacagatc cgctagacag 1328761 tgctgttatt acagttggta ccattaccgg aggctcggca caaaatatca ttgcagaaac 1328821 ggcccacctg gaaggcacga tccgcacgct ttctgaagaa tcgatgaaac aagtaaagga 1328881 acggattgaa gatgtagtga aaggaatcga aatcggattc cgctgcaaag gaaaagtgac 1328941 atatccgtct gtatatcacc aagtttacaa tacgagcgga ttaacagaag aatttatgtc 1329001 ttttgttgct gaacatcaac tggcgacagt aattgaagca aaagaagcaa tgactggaga 1329061 ggattttggc tatatgctga aaaaatatcc cggattcatg ttctggctcg gcgctgattc 1329121 tgaacatggg cttcatcatg ctaagctgaa tcccgatgaa aatgcgatag aaacagcggt 1329181 tcatgtcatg acaggttatt tttctgttta tgccaattaa gtacaaatga aagaataaaa 1329241 ttccataaaa tgagcactct agtaaacgga ggtgttcaaa aatggctaaa aaaattggaa 1329301 ttgaacaatc gttatcagat gtagaagctg ctttaaaaga aaaaggatat gacgttgtaa 1329361 tgatgaaaag ccctgctgat gctcaaggct gtgactgctg tgtcgtaaca ggtcttgata 1329421 ataatgtgca agggatagcc gatacggtaa cacaagcacc tgtcattaca gcttccggga 1329481 tgacggctga agaaatttgt agcgaagttg agagcagaat tcagtaataa aaaaaccgaa 1329541 gcaaaaagct tcggttcttt tatttattct gtttctttag ggaaagcgcg gtcgaacgcg 1329601 ttctttattt cttttctcaa cactcgttcg actcgccact gttccatatt ttctgttttg 1329661 gcaatgaccc tgattacaat ttcagaagtc cccagttctt gaatcccgat gacatttggg 1329721 ccttctttta tttgtggaag agccgctgcc gtttcatcac aaacctgctg taaaatatga 1329781 atcatttcat caatatttct ttcagccggc actttaatgt caacaagagc ctgcatggta 1329841 ccacgagaat gattgctcac gtttgtgatg tttctgttgg ggatgtaatg cagtgttccg 1329901 tcaaagctgc ggatttgagt tgtccttaag ccaacctgct cgacaattcc gtcaaaggtg 1329961 gaaacggtaa tataatctcc gacatccaat tgtttctcaa gcaaaataaa aaaacctgtc 1330021 acgatatcac tgacaagccc ttgggcgcca aatccgacag ccaggccgac gattcctgcc 1330081 cccgctaaaa gagcgcttgg atcataatga aacaaatcta gaaccatgac gaaaaatatg 1330141 aaaatcaatg tataagcaaa tatgttaaga gtcaggcttc ggagcgtatg tgcacgtccg 1330201 atagacaagc tattctgctc ctcgaatttt gcaaacagat gtttaatgat tttcatgcct 1330261 aatgatcgaa cgataaaata gagcaatatc ataatggcga gtttaatgag cagaacaccg 1330321 gcatttgtaa tcagtcccgc ccaatcatat tgtttaataa agtccatgtt gagctccttt 1330381 tctaattgat tgctgcacat tgagactagt taccctgtac atgaccatgt taaacgtttt 1330441 attcaaaaat gtcgaagcca aagacataca tgatttgtta aaaattgact caggaaatct 1330501 gcttttatat aatggcattg caatataact aaaaatggtt aatcaccctt tattttcatg 1330561 cgattttgac ctttaagcca aacaataaat tggagggata catatggcag aacgtatggt 1330621 aggtaaacaa gctcctcgtt ttgaaatgga agcagtcctt gcaagcaaag aattcggcaa 1330681 agtaagtctt gaggaaaaca tgaaaaacga caaatggaca gtgctgttct tctatccaat 1330741 ggacttcact tttgtttgtc cgacagaaat tacagcaatg tctgaccgct atgacgagtt 1330801 cgaagatctt gatgcagaag tcatcggggt ttcaactgat accatccata ctcatttagc 1330861 ttggatcaat acagaccgca aagaaaacgg tcttggccag ctgaaatacc cgcttgctgc 1330921 tgatacaaac catgaggtat cccgggaata tggcgtttta atcgaagaag aaggtgtggc 1330981 tttgcgcgga ttgtttatta ttaatcctga aggggagctt caatatcaaa ctgttttcca 1331041 taacaacatt gggcgtgatg ttgatgaaac gcttcgtgtt ctccaggcgc tgcaaactgg 1331101 cggactctgt ccggctaact ggaaaccagg ccaaaaaaca ctttaattct ttccaagaac 1331161 gaaaagcggt ctagcatatt cgttaggcct ctcttttaaa ataggaggga aaaagcaatg 1331221 aaattacgtc agcccatgcc ggaattgacg ggagaaaaag cttggttaaa tggtgaagtg 1331281 acgagagagc aattgattgg ggaaaagccg acgcttattc atttctggtc catcagctgc 1331341 cacttgtgca aagaagcgat gccgcaagtg aatgaatttc gtgataaata tcaagatcag 1331401 ctgaatgttg tagctgtaca catgccccgt tccgaagatg atcttgaccc tggtaaaatt 1331461 aaagaaacag ctgctgaaca cgatatcact cagccgattt ttgttgacag tgaccatgct 1331521 ttaaccgatg catttgaaaa tgaatatgta cctgcatatt atgtgtttga taaaacagga 1331581 cagctccgtc acttccaagc cggcgggagc ggtatgaaaa tgcttgaaaa acgtgtgaac 1331641 cgcgttctgg ctgaaacgga ataggtatct gactaaatag tatttcctaa aaacctgacc 1331701 tcatcaggtt ttttatttgt gcaaaaagca atggaagaag agtaagaagc ttatttttcc 1331761 aaatttgggt ataggaattg atgatttgtt tgattgatac gctaaaaaac acagctaatt 1331821 tttgatgttt ttcctcaatt ttagataaat ctcatatctc ataactcgaa aattgtagat 1331881 attacactaa atttctttaa agaagtaagt aaaatatata ttttcaacat tataccaaat 1331941 aaactagaaa gccccttaat cccttgagaa taaaggactc ttttgaaaaa taaaacattt 1332001 tcagaaaata aggaattttt catagagtaa atataatagt aaaatgctaa aataatagtt 1332061 gataaaatta cttttgtaat ctaatatctt aattaaagat gttaattttg atagggggta 1332121 cattgaggaa tgtttaatga aagagaagct ttgcgcttgc ggttagaaca attaaatgaa 1332181 gctgaagtga aagtcattcg tgaatatcaa attgaacgtg ataaaatata cgcaaaatta 1332241 agagagctgg acagaaatgg aagcccttcc gaaatcaaaa aggatttccg ttctgaaaaa 1332301 aaacctgact ctctgccggt tctcgctgag cttgcggctc aggaaatcag aagctatcag 1332361 ccgcaatcac agcagcagtc tgttcagcct cagcttcaat ctatttcctc tcttcctgcc 1332421 ggtataccag acggaacaac acgaagaaga agaggaacgg caagaccggg atcaaaagca 1332481 gctaagctgc gtgaagctgc tattaaaaca ttaaaacgcc acaacgcggc gattaagagc 1332541 tcggagcttc aaaaagagat tgaaaaagaa agcggtcttg aaatccctaa tatgacaacg 1332601 tttatgcaaa gcttaattaa aatgtacccg gaagtgaaaa agccatatcg cgggcagtac 1332661 attttagagg gtgaaatcga atctgcagaa tcagcaaacg aataaatata aagaaaaact 1332721 gcttggcatc gctcaagcag tttttttatt gaggtttttt ctgtgaaggt ttgttttctt 1332781 tttcaagatt aagcttatac acccactttt gataaggctt ttcttcagcg gctctgtttt 1332841 tcagctcttc gattgtatgg ctcttggcct ggtctgatga ttgggcgtgg gcaagctgtt 1332901 tttgaagcac atgtatctgt ttggtgacat cttcaaggat agtctctaca tgatttggct 1332961 gcgcgtaggc cgctggagct tcttcttccg ttttttcttt ttgtttcgtg ccgccatcaa 1333021 tatcggcaaa atgagaagca atccaggcat cgctttcatc aagttgccgt ttatacgata 1333081 taatagtttc gtgaaataat ttttctttcg ttttttctat gtctagcagt ctttctttcg 1333141 tttctatgat tcgatctttc atatgatcaa cttctatttt aatatgtttt agctgatatt 1333201 ctttttctac catttgctct tttagacgcc cgttttcggc ttttatcaat tcggcttgct 1333261 gttttgcctg aagcagtgca ttttgttcct gctcaattga ggcttgaagt tcgctgatcc 1333321 gtttatgaag atttttattt tcttcttcga ttttgacttt cgcaatatga agtttatgtt 1333381 tttcttcgat ttcggctctg cgtttatagg tttcagcaga tagaagctcc tgcaaaacaa 1333441 cgattttatc aagcagttca gctcttattt ggtgcagggt ttggctggtg tgggaggcat 1333501 gtttttcttt tgttgacata tgtgttaatt cggcagacag ctgctggagt ttttctttca 1333561 tatcggtatt ttctttgagc agtttgttat ttttctgatg aaagtagctt gcttcaagtt 1333621 cagaaatcag cttatggcac cttgaaagct cggattttaa ataaaggttc tcctgagaca 1333681 cgtcgtggaa aaaaggacct gatcttttca ttcgaaccat ctccctcatg atgttaacac 1333741 tacaatatgc aaatactgaa cagctattcc tctttaataa acagacaagc agtagcgttg 1333801 agcctttgct tttgctatgc ttttaacgaa actagaggtg agatgatatg aagcatgtaa 1333861 acgtactgct ggcaggggga gcctcacgtc gctttggaga accgaaggcg tttgtcaaat 1333921 ggaagggcag gatgctttac gaatgcgcta aagaggcact tggagaacaa acggttatca 1333981 tcagccgtcc cgaatttatt gatagatttc aagaaaacgg tgaaaatgaa gtgtatcaag 1334041 atgctgagcc atttcaaggc atggggccat tggctggtat atataccgct tttaaaaaga 1334101 cagacggtga tctttatact gttctttcct gtgacacacc gctgatacaa agaaggacga 1334161 tgctggagct caaacgtctg atgattgccg gtgcggacgc ggtagtccca atttcagacg 1334221 gacaagtgca gccattgatt gcgatttacc acaaacgtat catgccagtt ctatacgatc 1334281 agctttctga gaagaggttg agaatatcag atttattagg cagaatttcg gtttgttacg 1334341 tacaggctga aaatatcgga gcaaacccgg cagagtttat caacattaat acacgtgatg 1334401 attttagctg tttggaagaa aaatcgaact ccctcaagcg ggactgacgg ggcaataaca 1334461 tgataagatg acataaaaga taaggagaac aggtttgatg gaggaacgtt attcacggca 1334521 aatcagattt aagcaaattg gggaagaggg ccagaaaaga ctggcagaca gccatgtgct 1334581 gattgtcgga gcgggagcgc tcggcactgc aggagctgaa gggctttcga gagcgggagt 1334641 cggtacgatt accattattg accgtgacta tgtggagtgg agcaatcttc aaaggcagca 1334701 gctttataca gaaagcgatg ccaaactccg catgccgaaa gccatggctg ccaaagagca 1334761 tctatcagcg attaacagcg agatacatat tgaggcgtat gttaccgaag gaacagccga 1334821 aacgcttgag ccgctgattg aaaaagcaga tgtcgtgatc gacgcgacag ataattttga 1334881 aacccgcatg ctgataaacg atcttgccca gaaaacaaag acaccttggg tctatggcgc 1334941 ctgtgtaagc agccagggaa tgttcatgac tgtcattccc ggagaaaccc cttgtctgtc 1335001 ttgtttgttt gagcaaattc ctgtcggcgg ggcgacgtgt gatactgccg gcattattcc 1335061 gcctgctgtg catatcgttt cagcatatca gcaggctgag gcattaaagc tgttaaccgg 1335121 ccaaaaagaa gcaatacagc gggggtttgt gacatttgat gtctggaaca attcgcatat 1335181 gaagattaac gttaatcatg tacgccgtga ggaatgccca tcttgcggag ctaatgcggt 1335241 atatccttat cttcaggatt ggaacacacc aaaagctgct gtactatgcg gccgtgatac 1335301 agtgcaggta aggtcagaat cattaaaaag aatcccgaaa caggagctca ttaagcggct 1335361 gaaaacaatc ggcaaggtcg aggctaatgc gtttttgctg catatttttt acgaggattt 1335421 cagaattgtc attttcaatg acggacgggc actggtgcat ggaacaaatg atgtgaaaga 1335481 agccaactcc gtgttggcaa gagtgattgg actgtaacaa caggaggggt cagaatgctg 1335541 gagaaaagaa caccgatacc ggtagacgag gcagttcggc gtgtctgcca ttttcaaaaa 1335601 caaggtgaaa cagaatgggt ggcgcttgaa gacagccttc atcggttttt agccgaagat 1335661 ataactgcgg atcaccacgt acctgcgttt gaccgttcgc catacgatgg ttttgctgtc 1335721 agagcgtgcg atacggcaga agcttcacgt gaaaacccag ttcggtttga agttattgac 1335781 catattggag cgggagcagt atctgaaaaa gaacttggcc cgtttcaggc cgtgcggatt 1335841 atgactggcg cgcaaatccc tgaaggggca gatgcagtcg tcatgattga actgactcaa 1335901 gcctttgagg agaatgggaa gtcatttatg tctttaaaac gccgctttca gacgggggat 1335961 aatatttcaa aaacaggtga ggacgctcaa aaagggagtg ttttactgac aaagggcacc 1336021 cgggtgacac caggagtgac ggctcttttg gcaacattcg gatacgcatc tgtgcctgtc 1336081 gtgagaaagc ctgtagtcgg gattatcgca accggtaccg aattgctgaa tgtcagtgat 1336141 ccgctggaac cgggaaaaat ccgcaacagc aatgcgagta tggtatatgc gcaagcgata 1336201 gaagcaggcg caacaccgct ttatttaggg aaaatctctg atgaactgga taaaagcttt 1336261 gctgcagtta aagaagcgat gaaaaaggtg gacttcctga tcacaactgg cggtgtgtca 1336321 gtcggtgact ttgacttttt gcctgcgatc tatgaaaaac tcggagcgga cgtgctgttt 1336381 aataaagttg ccatgcgccc gggcagcgtg acaacggtgg cgcatgcaaa cgatatgctg 1336441 ctgtttggcc tttcaggtaa tccgtcggca tgctatgtcg gttttgaact gtttgtcaaa 1336501 ccgataatcc agacatggct gctcaatgaa acaccgcatt caatttgtgc ggaagctgtt 1336561 ttgaccaagg attttccgaa gccgaaccca tttacccgat ttgttcgtgc gctcgtgcac 1336621 catcaggaag ggaagctgtt ggcgacaccc gttggcttag ataagtcgag ctctgtcaca 1336681 tcacttgcag atgccaatgc atttattatc ctgccgggcg gtacgcgagg ctacgaatct 1336741 ggcagaacgg ttcaagtgct gctcatcaga gaagagaatg gaagtgaatg gccttggtcc 1336801 gtcctttccc gatcgtccaa gttgtaggat ttcaaaacag cgggaaaaca acgtttattg 1336861 agcgcattct tgaaaaagcc tctgaacagg gagtccattt gggctgcctg aagcaccatg 1336921 gtcacggcgg tgaaccgcaa acgctcacgg aaggaaaaga cacggaccgt tacaaggcgg 1336981 caggtgctga tgtaacagcg gtagaaggtg ctggtgtgtt acagctgact gcccgccgca 1337041 attgggattt ggcacggctg attgagttat accaatttct cgaaacagac tgtcttctga 1337101 ttgaaggctt taaaaaagcc ccttatccta aagtggttat cctaagtgaa aaggaagatc 1337161 tggaagcgct gcaagcagta aatataatcg ccatcatcta tagaaaaaaa gagcatatga 1337221 cagagcatca gggattaccc gtttttcatg cggatgatcc ggttgccgtg gattttgtgc 1337281 tttcacagct gaagggggaa tctgcataat ggaacggttt gagattacga aaacacccat 1337341 taatactgaa aacatcatca aaaaagtgga gaaacgggaa gcgggagcca ttacaacatt 1337401 tattggtacg gttcgggaat ggacaaacgg aaaaagaacg gttcggcttg aatatgaggc 1337461 atatgaaccg atggccgtgc aaatgcttgc tcaaatcggc gctgaaatcg aagaaaaatg 1337521 ggaaggtgcc tcagctgcga tcacgcaccg tataggtgtg ctcgatatcg gtgaagcagc 1337581 ggtagtgatt gctgtatctt ctccccatcg aaaagccgca tatgaagcca atgagtatgc 1337641 gattgaacgc attaaacaga ttgtgccgat ttggaaaaaa gaaatttggg aagacggtga 1337701 gcaatggatc ggcgaccagc tagaaacgac agcttatccg aacggaaaac cagacctaag 1337761 cgagggagag cagcatgatt aaaattcttt tatttgcagg gcttgctgaa caggccggta 1337821 cacaagcaat agaaatagat atggaacaag caaccacaga tgaaataaaa gcgagtctaa 1337881 aagaacaata cggtcttgaa tctattgata cggctatgat tgccgttaac gaaagctatg 1337941 taaaagaaaa tacctctgta tcttcgggtg acacggtagc catcataccg ccggtcagcg 1338001 ggggatgaaa accggacggc atttcagccg tccggttttt ctgtatttca ttggcatatc 1338061 cccaagtatc ctcagcatac aatgattttc tgtaagcgtt tattctacat atgttactcc 1338121 ctataaagta agagactcac tccataatta gactgaaatt ttgaaaaata atagaaattt 1338181 atttcgggta tcgatatagt gaagatgata aatgttggaa aggtgctgga tatggagaca 1338241 tttaaaagat taaaaatgta ttattggccg tacagaaaag tgtttatgtg gtcgcttcta 1338301 gccatgcttt tgatgactgc aattactgtc gtttatccga ttatcctgca aattacgatt 1338361 gatgagatcg tactgggacg gcagtatcag cttgcggcgt gggtcagctt aggatttatt 1338421 gcggtgatgg ttttgaaagg aatggctacc ttttttcatc agtatttagg tgatatgttc 1338481 gggatcaaat ccgtttatcg gctgagaaat ggtctgtatg aaaaactgca gcggctttct 1338541 ttttcttact atgataacgc gaaaacagga gatttgatgt ccaggctgac tgctgatgtt 1338601 gaagggcttc gttttttctt atcatacggt ctcgctgagc tcattcgctt cggcctgctg 1338661 gtagccatca gcctgtcggt tatgttttac tattctgttc ctctcacgct tgtgacaata 1338721 gctgttctgc catttctcgc ggttgcggta taccggtttg acaaaagagt ccatcccgcc 1338781 ttcagaggca tccgcaaatc gtttgcgaaa ctcaatacaa aagttcagga aaatatcagc 1338841 ggcattaata cggttaaatc tctttccagg gaagattttc agatcagcac tttcaataaa 1338901 gccaatgcag aatacagggc gcagtattta caaacatcat ccatttggtc tgcgtatttc 1338961 cctttaatgg agttcattgg taacacttgt attgtagctc ttctctcata cggcggttac 1339021 ttggttatgc aaaatcagct caatcccggc gagcttgttg ctttcttcag ccttgtcaat 1339081 tatatgatgt ggcccattat gaacttaggt tttgtcatca atatgttctc tcaagcaaaa 1339141 gcgtcagggg aacgcctgct cgacattctg gaaaaagaag aagacattac agatcatcct 1339201 catgctttgc ataaacaaaa attaaccgga gatgtccatt tcaaaaatgt ttctcttgca 1339261 tacggaaaag aacaaacaaa cgcgctgtgc aatgtaagct ttgaggcaaa cagcgggaag 1339321 gtaatcggac tgttgggccc gacaggttca ggcaaaagct cagtgacaca gcttctcacc 1339381 agattttaca gtcctgttgg cggaatgatt accattgatc acaaacccat cacagattat 1339441 tcgttaaaaa cccttcgctc caatatcggg gtcgtacttc aagaatcctt cctgttttca 1339501 tctacgatta gatcaaatat ttcgtatggg cggccggatg cctcaatgga agacgtcatc 1339561 gaagcggcaa aaagggcgca ggctcataac tttattatgg agcttcctga tgggtatgac 1339621 accatgctgg gagagagggg aatggggctt tccggcgggc agaaacagcg tattgccatt 1339681 gcgagagcca tctgcttgaa cccgagcatt ttaatattgg atgatgccac aagcgcagta 1339741 gatatgcaaa cggagcacag catacagctt gccttaaaag aagtcatgaa aaaccgcaca 1339801 acctttatcg tcgctcaccg catttcttca ctgaaacacg ctgatgaaat tctcgttttt 1339861 aataaaggac gcattcgtga aaggggaaca catcatgagc ttcttgaaaa aggcggctac 1339921 tataaaaaga tttacgattt gcaataccgt gatgtcaaaa tgattaatga gccgcatgag 1339981 gtcggatagg gaggggccaa atgaaacaag cgaaaaaaca gggggtttta gagcgtttct 1340041 attactcttc agatgaaatc attgaaaagc cgtttaactg ggctcaaatg tggcggctgc 1340101 tgagctatgt caaaccatat cgaaaaacaa ttttgccgct ttcttttctc actgtattga 1340161 ttggcactgc tgtgaagctt gtgatcccca ttttgatcgg cgtttatgtt cttgatcaag 1340221 cgattacagg gagaaactcg gagctgctga ttcagctcat ttttattatt agcggtttat 1340281 atgtcctcaa ttacgccgcc aatgtgttaa gaatcaggtg gatgaatcag cttggccagc 1340341 atgtcattta cgatttgcga cagcatttat ttacccatgt gcagcgctta tcccatcgat 1340401 tttttgatca gcggtcggcg ggatcgatct tagtcaggat catgaatgat attaactctc 1340461 ttcaggagct ctttacaagc ggagtcatca atttgttgac cgacttgctg cttctggccg 1340521 gcgtgattat tattttgttt acgctgagcc ctgagctgac tatagccatc atggtgacat 1340581 tgccgattat gttttttatt tcaacaagtc tcagaaaaaa aatacgccga tcctggcaaa 1340641 cggtacggct gaagcaatcg aagctcaact ctcatctaaa cgaaagcatt cagggcatcc 1340701 gggtcacgca ggcatttacg caggaagaag aaaacatggc gtattttgac ggtgtcaatc 1340761 aggagaacta cgaatcatgg cgggaagcaa ctagaaaaaa tgccatgttc cgtccgcttg 1340821 tagaaatgac gaatgcgatt gggacggctg tcttgatttg gtatggagcc acactcatca 1340881 tgaatgaaac cattacgatt ggcgtcttcg tttcttttgc tttctatctg ggaatgtttt 1340941 gggaacctat ttcgagactg ggtcaggtct ataatcagct gttaatgggg atggcatcat 1341001 cagaacggat ttttgagttt ctggacgaac agccaaatgt caaggagaag ccgaatgcca 1341061 ttcataatga aaagataaat ggggagatca gttttgaaga ggttgaattt tcgtatgatg 1341121 aaaaacgaaa agcccttcac gccgtttctt tctctattcc tgcgggatcg acgcttgcgc 1341181 ttgtcgggca tacagggagc gggaagacga cgattgccaa tttaatcagc cgtttttatg 1341241 atgcggccgg aggcaccatt aaaatagacg gtataccgat taaggatctt tcccttgcca 1341301 gtctgcgctc tcaaatcagc attgtcctgc aagatacatt tattttctcc gggaccatca 1341361 tggaaaatat tcgttttgga aggccaaatg cttcggatga agaggtgatg aaagcgtccc 1341421 aagcggtcgg agcggatgag tttatttccg atttagcgga aggatacgca acagaggtag 1341481 aggaaagggg cagcgtactg tctgccggtc agcgccagct catttcattt gcaagagcat 1341541 tgctcgccga tccggctatt atcatccttg acgaagcaac ggcaagcatt gatacagaga 1341601 cagaagtaaa aattcagcaa gcgttaaaaa cgcttctgaa agggcgtaca gcagtgatga 1341661 tcgctcacag attgtctacg atccgcgacg ccgaccgcat cattgttctt gatcacggca 1341721 ggaaaataga agaagggaac catgatcagc tgctcgctaa aggaggcatt tatgccgggc 1341781 ttgtgaaagc gcaatacagc acagcgatag aataatatga aaagccttca atattgaagg 1341841 tttttggaaa tttattagaa aaacatgaaa ctttttgata tccttcccgt actatttgtt 1341901 agatattctc aaggaggttt tgaaatggaa acgaatgtag aaaaaaacag cggaacggcg 1341961 actgaaaagc cttcactttt cggagtaatc acaagtccgt ccgttcaatt tgaaagaata 1342021 agagaaaggc cggctgtatg gggaccgctt ttgattgttg cagcaattat catcgtcggt 1342081 gccgtgctgc aatcactcgg tacggattat agtgagcttt tgaaaagcca ggatacgcaa 1342141 gggctatctg ctgaacaaat ggaaactgtc gcaacaataa ccaaatttgg cggaatggca 1342201 ggcgctatta tcggcggtat cgcagcatta tttattgccc ctcttattta ttggctctgt 1342261 gtaaaagtat caggcggtgt tacgacatat aaaaaaatgc tttctctcag tctgtttgtc 1342321 tctttgatta gcagtctcgg attattggtt aatggaatcg ttgcttttac gactgacgtg 1342381 aatcctcttt acagcacgac gtcactcgca gggattatcc catctgacgg ggctctcgcc 1342441 agtgtgttaa atacctttga aattttcagc atctggagct ttgtattatt agcaatcgga 1342501 cttcacaaaa cgggaggcat ctcaaaaaaa gccgggtgga tttcagcaat cattctattc 1342561 ggaattttag ttgtattttc gcttttttca ggtttaatca attctgtggc gggtgcataa 1342621 gctcatgaaa aaagtctgga tcggaattgg aatcgcagtt atagtcgctc tttttgttgg 1342681 aatcaatata taccggtctg ccgctccgac aagcggcagc gccggcaagg aggtacagac 1342741 ggggagcgtt gaagaaaatg aaatctcatc aacggttatg gttcctggca cgctaaaatt 1342801 ttcaaatgaa cagtatgtct tttatgaagc ggataaaggg acattagaag acattaaagt 1342861 aaaggaaggc gataaagtta aaaagggcac ggctttagtc acctatacaa atgagcagct 1342921 gagcctggaa aaagaacaga accagttaac gtctgaatcc aaccggcttc aaattgacca 1342981 aattcaagaa aagttaaaag ccttggacag caaagaaaga gaactggaaa aacaggtagg 1343041 aaagaaagaa gcagaaaaac aaatcgaatc tgaacggaca gagcttcaaa tgcagaaaaa 1343101 aacagcggag atcgaattaa aacaaaccga gcttcagcgg cagtcacttg ccaaccgggt 1343161 gtcagattta gaagtgaaaa gcgaaattga aggcaccgtt atttctgtca accaagaagc 1343221 ggcatccaaa aagtcagata ttcaagagcc tgtcatacat atcggcaacc caaaagacct 1343281 tgtcgtctca gggaaattgt ctgaatacga tacattgaaa gtcaaaaaag gccagaaggt 1343341 cacactcact tcagatgtaa tacagggtaa aacatggaaa ggcacggttt ccgcagtcgg 1343401 gcttgttccg gatcagcagg agagcgctgc ggcacaagga acagaacagg cggtccaata 1343461 cccgcttcaa gtgaaaataa aaggaaatct tccagaagga aagccaggct ttaaatttat 1343521 catgaatatt gaaacagata aacggaaagc aaatacgctt ccttcaaagg cagtcaaaaa 1343581 agaagatgac caatattatg tgtatacagt aaaagacgga aaagcaaagc gagttgatgt 1343641 caaaatcggc gaagtgacag atgacctgac agaaattaaa gaggggctta cccaagatga 1343701 tcaagtcatt ttgaatccat ctgatcaggt gactgacgga atggaagtga aatcctaaat 1343761 gattcagctt tctaatgtgc gaaaaagcta ccagatcgga aaggaaacgt ttgatgttct 1343821 ccattctatt gatttggaca ttcatcaagg tgaatatgtc tcgattatgg ggccgtcagg 1343881 atcaggaaaa tcgacgatca tgaatattat cggctgtctt gatcggccga cttccggtac 1343941 atatcaattg gacggcgaag acatttcttc atataaagat aaagaactgg cggcagtccg 1344001 taaccggtcc atcggttttg tatttcagca atttcagctt cttccgcggc tgaacgcaaa 1344061 aaaaaatgtc gagctgccga tgatttattc cgggataggc aaaaaggaac gtcaagagcg 1344121 ggctgagaga gcattggaaa aggtcgggtt agccgatcga atgctccaca tgcccaacga 1344181 gctgtcgggc gggcagaagc agcgggtggc gattgcgagg gcgatcgtga atgagccgaa 1344241 attgatttta gctgatgaac cgaccggcgc gctggatacg aaaacaagcg aggcgattat 1344301 ggatcagttt acagcattaa atgccgaggg aacgacaatc gttctggtta ctcacgagcc 1344361 tgaagtagca gattgcacga atcggatcgt catggtgcgt gacggaaaca ttgttcctgc 1344421 cagctccgga caaaggagtg tgggagaatg agcctgttgg aaaacatcag aatggctcta 1344481 agctctgtcc ttgcccataa aatgcgttcg atcttaacga tgctcggcat tatcattggt 1344541 gtaggctctg tcattgttgt cgttgcggta ggacagggcg gcgagcaaat gctgaagcag 1344601 tcgatcagcg gcccgggaaa tactgtggag ctgtactata tgcctagcga cgaggagctt 1344661 gcaagcaacc cgaatgccgc agctgaatct acgtttacag aaaacgatat taaaggttta 1344721 aaaggaatag aaggcattaa acaagtcgtt gcttcgactt ctgaaagtat gaaagcgcgt 1344781 tatcacgaag aagaaaccga tgctacggtt aacggaataa atgatggata catgaatgtc 1344841 aattctttga aaatcgaaag cggcagaacc tttaccgaca atgactttct cgcggggaat 1344901 agagtcggaa tcatctctca aaaaatggct aaagagctgt ttgataaaac ctcccctcta 1344961 ggtgaagttg tctggattaa cggacagccc gttgaaatta tcggcgtgct gaaaaaagta 1345021 acaggcttgc tttctttcga tttaagtgaa atgtatgtgc catttaatat gatgaaatcc 1345081 tcttttggca caagtgattt cagtaacgta tcattgcagg tcgaatcagc agacgacata 1345141 aaatcggctg gaaaagaagc ggcacagctg gtaaatgaca atcatggcac agaggattcg 1345201 tatcaagtga tgaacatgga agagattgcg gccggaattg gcaaagtaac tgcaattatg 1345261 acgacgatta tcggctcaat tgcaggtatt tcccttttgg tcggcggaat cggtgtcatg 1345321 aatattatgc tcgtatcagt cacagaacgg acgcgggaaa tcggaatcag aaaatcactt 1345381 ggtgcgacga ggggacagat tctgactcag tttttaattg aatcagtcgt attgacgctg 1345441 attggcggtc tggtcgggat tggtattgga tacggagggg ccgcgcttgt ttcagccatt 1345501 gcgggctggc cgtcactcat atcctggcag gttgtatgcg ggggcgtgct gttcagtatg 1345561 ctcattggtg ttattttcgg catgcttcct gcaaataaag ccgcaaagct tgatcccatt 1345621 gaagcgctgc gttatgagta gcctcatgca acatgcatga ggttttttta tgtttagtga 1345681 tttctactat gaatataaaa gacttttttc attaaaataa gaagaaaatg tcgtacaatt 1345741 gtccttattt ttgtcgaatt tacagtttac aaaccctata gacatacgtt aatatggaga 1345801 aacgtgaaag attttgatag ttattgaatg aatttgaatg attttagttg cctaaaccga 1345861 aaatagcgtt tacaatgaaa ttgtattcaa aatgaatacg ttttcattag gaggtgaagc 1345921 atgctaactc ctgaacggca tcaattgatt attgatcaaa tagaaaagca tgatgtggta 1345981 aagattcaag agcttataaa tctgactaat gcttctgaat caacaatcag aagagattta 1346041 tcgacccttg aagaacgcgg ttttttaaag cgcgttcatg gtggagcggc caagctttcc 1346101 gatatcagac ttgaacccga tatgcttgaa aaatcatcca aaaaccttca cgataaactg 1346161 aagattgctg aaaaagctgc ttctctttta gaagaagggg attgcattta ccttgatgca 1346221 ggcacgacga cattgcacat gattgatttt atggataaaa ccaaagatat tgtcgttgtc 1346281 acaaacgggg taatgcatat cgatgcatta ataaggaaag aaatttcttt ttatctgctt 1346341 ggaggatacg taaagcacag aacgggcgcg attattggag gcgcttcatt ggttgccatg 1346401 gaccagtaca gatttgacaa gagttttctg gggacaaacg gtgtccatac agaggctgga 1346461 tttacaacgc cggaccctga tgaggccctt ttaaaacaga aagcgatcaa acaggcaaaa 1346521 cacgcttacg tcttagcaga cccttcgaag ttcggagaaa tttcattttc ggcattcgcc 1346581 ggaataggcg acgcaacaat cattacgact gacgctgaag agcttacatt cgataattac 1346641 caagaaaaaa ctgtcgtaaa ggtagtgaaa ccatgattta cactgtaaca cttaatccat 1346701 ctgtcgatta tatagttcac gttgaagatt ttactgtagg aggcctgaac cgttcttcgt 1346761 atgataccaa gtatccaggg ggcaaaggca tcaacgtatc gagactgctg aaaagacacc 1346821 atgtggcgtc taaagcgctc ggattcgtcg gcggatttac cggagaatat atcaaaacat 1346881 ttttacggga agaaaacctg gaaacagctt tttctgaagt aaaaggggat acccgtatca 1346941 atgtaaagct gaaaacgggt gatgaaactg aaattaacgg gcagggaccg acaatttcgg 1347001 atgaagattt caaagccttt ttagaacagt tccaatcttt gcaagaggga gatatcgttg 1347061 ttcttgcagg aagcattcca tcttcactcc ctcacgatac ttatgaaaaa atcgcagagg 1347121 cctgcaaaca gcagaacgca cgagttgttc tggatatctc aggcgaggct cttttgaaag 1347181 caacagaaat gaaaccattt ttgatgaagc caaatcatca tgagcttgga gaaatgttcg 1347241 gcacggccat tacatctgtt gaggaagccg ttccttatgg gaaaaagctt gtagaacaag 1347301 gcgctgaaca tgtaatcgta tcaatggccg gagacggagc gcttctgttt acgaacgaag 1347361 ctgtttattt tgctaacgtg ccaaagggga aattggtaaa ctcagtcgga gcaggggatt 1347421 ccgttgttgc aggtttcctt gccggaattt ccaaacagct gccgcttgaa gaagcattcc 1347481 gcttaggagt tacttcaggc agtgctaccg cgttctctga agaacttgga acagaagaat 1347541 ttgtccagca gcttcttcct gaagttaagg tcacacgtct atagaggagg aaacacaagt 1347601 gaaaataact gagcttttaa cgaagcatac gataaagctt aatattgaga gcaaagaaaa 1347661 agaaaatgtt attgacgaaa tggtcactgt tcttgataag gctggaaagt taaatgaccg 1347721 acaagcctat aaagaagcca ttttaaatcg cgaaagccaa agctccacgg gtatcggtga 1347781 aggaatcgct atcccccatg cgaaaacggc aagcgttatc aacccggcga tcgcgttcgg 1347841 acgttcaaaa gacggcgtcg attatgaatc attagacggc cagccggctc acttagtgtt 1347901 catgatcgcg gcgactgaag gcgcaaacaa cactcacctt gaagcattgt caagactttc 1347961 aacgctgtta atgcgtgaag aaatccgtaa gcagctcctt gaagctgagt ctgaagatgc 1348021 catcatcgac attattaatc agcacgataa agatgatgac gaagaggaag aggaagaaga 1348081 agcggcacca gcacctgccg gaaaagggaa aattttagcg gttactgcat gcccgacagg 1348141 tattgcccat acattcatgg ctgcggatgc ccttaaagaa aaagcgaaag agcttggtgt 1348201 ggaaattaag gtcgaaacaa atgggtcaag cggcattaag cacaagctca ctgcccaaga 1348261 aatcgaagat gcacctgcaa tcattgtcgc agcggacaag caggttgaaa tggaacgttt 1348321 taaaggcaag cgcgtacttc aagttcctgt aacggcgggt atcagacgtc cgcaagagct 1348381 tatcgaaaaa gcgatgaatc aagatgcgcc gatttatcaa ggcagcggcg gcggttcagc 1348441 agcttcaaat gatgatgaag aagcgaaagg caagtctgga agcggtatcg gaaacacgtt 1348501 ttataagcac ctgatgagcg gtgtcagcaa catgcttccg ttcgtagtcg gcggcggtat 1348561 tctcgttgcg atttcattct tctggggaat tcactctgct gatccgaatg atcctagcta 1348621 caacacgttt gcagcagcat taaactttat cggcggcgac aatgcattaa aactcattgt 1348681 tgcagttctg gccggtttca ttgcgatgag tattgcagat cgtcctggtt ttgcgcctgg 1348741 tatggtcggc ggatttatgg caactcaagc gaatgctgga ttcttaggcg gcttaattgc 1348801 cggattcctt gccggttatg tcgtgatttt actgaaaaaa gtatttacgt ttatccctca 1348861 gtcacttgat ggattaaaac ctgttttgat ttacccgctg ttcggtattt ttatcactgg 1348921 cgtattaatg caatttgtcg tcaatacacc tgtagcggca tttatgaatt tcttaacaaa 1348981 ctggcttgaa agccttggta ctggaaacct tgtgttaatg ggtattatct tgggcggcat 1349041 gatggcgatc gatatgggcg gtccgcttaa taaagcagcc tttacgttcg gtatcgccat 1349101 gatcgatgca ggcaactatg cgcctcatgc agcaatcatg gccggcggta tggttcctcc 1349161 gcttggtatc gcacttgcaa caaccatttt cagaaacaaa ttcactcagc gtgaccgtga 1349221 agctggtatt acatgctatt tcatgggagc tgctttcgta acagagggag cgatcccatt 1349281 tgctgcggct gatccgcttc gcgtcatacc agctgctgta gtcggtgcag ctgttgccgg 1349341 cggattaact gaattcttcc gagtaacgct tccggcgcct catggaggag tattcgtagc 1349401 tttcattaca aaccatccga tgctttacct tttaagtatc gtgatcggtg ctgtcgtgat 1349461 ggcaattatc ctcggtatcg tcaaaaaacc tgttacagaa aaataagaaa aaaagcgtcc 1349521 ttggttcgaa aggacgcttt ttcttatccg gccggcaggg agcgcggtta agttatgtat 1349581 tttattcttt tttatgataa agtaaaagaa gagaaacaac tgacatagca attgtctagg 1349641 aggaaacact ttgaccgagg aaaaaaatac gaatactgag aaaacggcga agaaaaaaac 1349701 caatacgtac ctggaatggg gtaaagcgat tgtcatcgct gttctgctgg ctctcctgat 1349761 ccgtcacttt ttgtttgaac cgtatttagt tgaaggttca tctatgtatc ccacattaca 1349821 tgacggagaa aggctgtttg tgaataaaac agtcaactat atcggcgagc tgaagcgcgg 1349881 agatatcgtt attatcaacg gtgaaacttc taaaatccat tatgtaaaaa gattgatcgg 1349941 aaagcctgga gaaaccgttc aaatgaagga tgacacgctt tatataaacg gtaaaaaagt 1350001 agccgagcct tacttgtcta aaaacaagaa ggaagcagaa aaacttggtg tcagtctgac 1350061 aggagacttt ggaccggtta aggttccgaa aggcaaatac tttgtcatgg gagataaccg 1350121 gctgaattct atggacagcc gaaacgggct gggactgatc gcggaagatc gaattgtcgg 1350181 cacatcgaag tttgtctttt tcccgtttaa cgaaatgcgt caaacaaaat aaaaacgcct 1350241 tgctggccta ggacagcagg cgtttttatt ttgaaaaaga agcgaccaat gcaatgcata 1350301 aaaccgtgat gaacactgaa ccgataatag ccagcacact gaagaaaagg tgaacctgtt 1350361 tgttctcttt tccgcgcttt tctaatagcc gtttagaaaa aatgtgcgaa aatatgtaaa 1350421 taagggctat gcctatatat aagccgatat ctttggcggt aaagcctgtt acggcaaggt 1350481 aaaagcccgt aaaaaagatc agtaagcaat attcagtaag tgttaaaagc ctcaacgtgt 1350541 tcctccatga gagtgtgtaa ttttccaggc ggatgcattc tctctcttta attgtaacac 1350601 agctggctgg tttgggtgta taagtgtttt ctctctgttt tatcagggaa tcatttctct 1350661 tgccctgcat tcatggtata cttttattga tgatagacat gatggaggat aataaatgat 1350721 tgctgtaaat aatgtaagct tgcggtttgc ggatcgcaag ttatttgaag atgttaatat 1350781 taaatttacc ccaggcaact gctatgggtt aattggtgca aacggtgccg gtaaatcaac 1350841 gtttctaaag gtgctgtcag gcgaaatcga gcctcagaca ggcgacgtgc atatgagtcc 1350901 tggcgagcgt cttgccgtct tgaagcagaa ccattttgag tacgaagagt atgaagtgct 1350961 gaaagtggtc attatgggcc acaaacgcct gtatgaagtc atgcaggaga aagacgctat 1351021 ttacatgaag cctgatttct cagatgagga tgggattcgt gctgctgagc tagaaggtga 1351081 attcgcggaa ctgaacggtt gggaagcgga aagtgaagct gcgatcctgt taaaaggcct 1351141 tggtatctca gaagatctgc acacaaaaaa gatggcagac ctcggcggtt cggagaaggt 1351201 aaaagttctc ttggcacagg cattattcgg caagccggat gttctgctgc tcgatgagcc 1351261 gacgaaccac ctggaccttc aggcaattca gtggcttgaa gagtttctga ttaactttga 1351321 aaacacagtt attgtcgtat cccatgaccg tcacttttta aataaagtat gtacgcacat 1351381 tgccgacctt gattttaaca aaattcaaat ctatgtcgga aactatgatt tctggtacga 1351441 gtcaagccag ctggcgttaa agctttctca agaagcgaac aagaaaaaag aagagcagat 1351501 taaacagctt caagagtttg tcgctagatt cagcgccaat gcgtctaaat ctaagcaggc 1351561 tacatcaaga aagaaacttc tcgaaaaaat cacgctggat gatattaaac cgtcttcccg 1351621 ccgctatcct tatgttaact tcacgccgga acgggaaatc ggaaatgatg ttcttcgcgt 1351681 ggaaggctta acaaaaacaa tcgatggcgt aaaggtgctt gacaatgtca gctttattat 1351741 gaatcgagaa gataaaattg ctttcactgg ccgaaatgaa cttgctgtta ctacgctgtt 1351801 taaaatcatt tccggggaaa tggaagctga cagcggaacg tttaaatggg gtgttaccac 1351861 atctcaagcg tattttccaa aagacaacag cgaatatttc gaaggcagtg atctgaacct 1351921 tgtagactgg cttcgccaat attctccgca cgaccaaagt gagagctttt tacgcggttt 1351981 cttaggacgc atgctgttct ctggagaaga agtccacaaa aaagcaaatg tactttccgg 1352041 gggagaaaag gtccgctgta tgctgtcgaa agcgatgctt tctggcgcca atattttaat 1352101 tttggatgag ccgaccaacc atttagacct agagtccatt acagcgctca ataacggctt 1352161 aatcagcttt aaaggcgcta tgctgtttac ttcccatgac catcagtttg tgcagaccat 1352221 tgccaacaga attatagaaa ttacacctaa cggcatcgtc gataagcaaa tgagctatga 1352281 cgagttcctt gaaaatgctg atgtgcagaa aaaattgact gaactatacg ccgaataaaa 1352341 aagcagagat ttctctgctt tttttgatac ctaaatgtga aaggagatca caacatgaaa 1352401 tttttggttg tcggagcagg tggagtaggc gggtatattg gcggacggct ttcggagaaa 1352461 ggaaatgatg tgacatttct cgtgcgccaa aaacgagctg agcagcttaa aaaaaccggg 1352521 cttgtcatcc atagtgaaaa agggaatgta tcatttcagc ccgaactaat cagtgccgga 1352581 gaaacagggc aatttgatgt cgttatcatt gcttctaaag catactcgct tggtcaagtg 1352641 atagaggatg tcaaaccatt tatccatcaa gaatctgtca ttatcccttt tttaaatggg 1352701 taccgccact atgagcagct atttgcggca ttttcaaaag aacaggtgct gggcggcctg 1352761 tgttttatag aaagtgcttt agacaacaaa ggagaaattc atcatacgag cgcatcgcat 1352821 cgttttgtat ttggagaatg gaacggcgag cgtacggagc ggataagagc gcttgaagag 1352881 gcattttcag gtgtgaaggc tgaagtcatc attagcgggc atatcgagaa ggacatttgg 1352941 aaaaagtatc tctttattgc agcgcaagcg gggatcacaa cgttatttca acgaccgctt 1353001 ggcccaatcc tcgccacaga agccggacgt cacacggccc aaactcttat tggggaaatt 1353061 tgcactgttt tacgaaaaga aggtgttccg gctgatccgg ctcttgagga agagagcttt 1353121 cgtacgatga ccagcatgtc ttaccatatg aagtcctcca tgcttcggga tatggaaaac 1353181 ggccaaacga cagaaggcga ccacctgcat ggatttttga ttgaaaaagc aaaacgttta 1353241 tctctcgctg caccagtatt agaaaccgtt tatgcgaatc tgcaaatgta tgaagcagaa 1353301 aaataaaaaa aggaggcgga aaagcctcct tttatttact taaaaagccc aatttccgtt 1353361 tctgaagata ggctctcttt tcccgtctgc cgtaattccg tcaatattca tatccttaga 1353421 accgatcata aagtccacgt gtgtaatgct ttcatttagg ccttctttga caagctcttc 1353481 acgagacatc tgctttccgc cttcaatatt aaaggcatag gcgcttccga tcgccaaatg 1353541 atttgacgcg ttttcatcaa acagcgtgtt atagaaaaga atgtttgatt gtgatatagg 1353601 cgaatcgtaa ggaacaagtg ccacttcacc taaatagtga gaaccttcat ctgtttccac 1353661 cagttctttt aaaatatcct cacctttttc agctttaatg tcgactatac ggccattttc 1353721 aaacgtcagg gtgaaatttt caataatatt tccgccgtag cttaatggtt ttgtgcttga 1353781 taccactccg tcaaccccgt ctttttgcgg cagcgtgaac acttcttctg tcggcatatt 1353841 ggccataaac tcatggccac tttcattcac gcttcccgca cctgcccaaa catgcttcct 1353901 aggcagctta attgttagat cagttccttc tgcttgataa tgtaaggcag cgtaatgtct 1353961 ctcgttcaaa tggtcaactt tttcatgaag attttggtca tgattgatcc acgcctgaac 1354021 cgggttgtct tcatttacgc gcgtcgcttt aaaaatttct tcccacagaa ggtggatcgc 1354081 ttcctcctct gatttgccag gaaacacctt gtgagcccag cctgctgatg ccgcacctac 1354141 gacagtccag ctgactttgt ctgattgaat atattgtctg tatgtatgta atgctttgcc 1354201 tgctgctttt tggaatgccg caatccgttt ggaatctata ccttttagca agtctgggtt 1354261 cgacgacaca acagaaatga aagcagctcc atttttggca agctcttctc tgccttttgc 1354321 ttcccattca ggatattctt caaatgcttc aaacggcgca agttcgtatt ttaatttggc 1354381 gacttcgtca tcctgccaat tcacggtgac gttttttgcg cccttttcat atgcgtgttt 1354441 tacaattaaa cggacaaaat cccgaacgtc tgttgaagca tttacgacta catactggcc 1354501 tttttggaca ttaacgccga cttctaccgc cagctgtgca tatgtattta atttctgtga 1354561 aaatgaatcc atgaatcatt cctccaagct tttttctcat catatcaaat atgatcctat 1354621 aaaggaaaga aggagcccaa agtgaaaaac ccaaaacgac acgtcttggg ttttttcaat 1354681 attatggatg attcagtttt acagtgccgc ctgcaggcga atggggcata tttgccaaag 1354741 aaatgctcat gcctccaaga ataattccgc ttaaaatggc tgcgatcgct actcttcttc 1354801 ctaaatctct tagcatctgt ttcctcctta acgtttctcc atttcccaca atatgaagga 1354861 agtgaggaaa aaagaagcaa gaaatttgcc gcgtgtgaga attttgcggg taaagactat 1354921 ttaattgcct tttgcagctt atcaatcact tctaaagaac ggcctgtgcc gattgctaca 1354981 gattcaagcg ggttttgcgc cacgtgtaca ggcacgacaa tctcttctgt gagccattct 1355041 ttaattccat taaggagcgc gccgccgcct gttaaaataa cgccgcgatc aacaatatct 1355101 ccgctcaatt caggcggaca gtcctcaagt gtcgctctga tggcttcaag aatatgcagg 1355161 agggattcac gcattgcatc ttgaatttcg ttggattgaa gcataatggt ttttggaaga 1355221 cctgtcacga ggtcacgtcc ccgaatttcc attgcctctg gtatatgttc aatcagagca 1355281 tggccaattt ccatttttac ctgctcagct gtgcgttcgc cgatcagcaa attgtatttt 1355341 ttacggacga aagaaacgat atcctcatca agctggtctc cgccgatcct gatagaatgg 1355401 caggaaacaa cgccaccgaa ggaaataata gcgacctctg tcgtccctcc gccgatatct 1355461 actaccacat tggcaaccgg ctcatcaacc ggtaaatccg ctccgatggc ggctgcaact 1355521 ggctcttcga ttaaatgaac gtttttcgcg ccgcaatttt tcaccgcatc actgatggcg 1355581 cggcgttcta ctgctgttga gcctgatggt gtgcaaacga ctacgttcgg ttttctgaac 1355641 gacatgccga tgctttttgc ggcttttttc ataatgtgct ttagcaggtc agttgtcata 1355701 tcatagtctg cgatcacgcc atctttcatc ggtctgacag cgacaatttt tcccggtgtt 1355761 ttaccgatca tgtttttcgc gtcagctccg attgcaagca ctgcttttgt cgtcgtatcc 1355821 actgcgacaa cagatggttc atttaggata atccctttat ttttgctgta aacaagtata 1355881 ttagctgttc ctaagtcaat cccgatttca gttgattgaa acatgttttc acccaatctc 1355941 tatcctaatt taatatgatt ctacatttaa agtttctcag aaatactgcg atttttgggg 1356001 gtgtgcgtcg gtaaagaaat gtttttgtaa aaaatcaagg aactgtgtaa cagaagtaat 1356061 acatttttcg gttttatgga aaaaatatct tgtaattctt atagaaagcg ggaaactttt 1356121 tcaaagtttc attcgtctac gatatattga ggtacatcct taaaacatta catgagaaaa 1356181 gaaacattta aaggaagaag ggtttttatg aaatcaatag gtgttgtgag aaaagtagat 1356241 gaattaggcc gcattgtcat gccgattgag ttgagacggg cattggatat tgccataaaa 1356301 gacagcattg agttttttgt tgacggagat aaaattatct tgaaaaagta caaacctcat 1356361 ggcgtttgtt taatgactgg agaaatcact tcagaaaata aagaatacgg caacggtaaa 1356421 attacgctaa gccctgaggg tgcacagctg cttctcgaag aaattcaagc cgctttaaaa 1356481 gaataaaatt atgctaaaaa aggcggagtg atatcatctc cgcctttttt gcgtgccaat 1356541 ttttgattac cgccgcctaa gataagacat caagatattt ggtaatgaat gatttgggat 1356601 actttacata ttttactcaa ttatttgtcg aagaatggta caataagtag agaaacacaa 1356661 gcggcaggtg gtcatatgag aaaatatcaa gctcgtatca tttccatcat tttggcaatg 1356721 atttttataa tgttttggga ttatttattt tattttatag gcaaaaaccc gattaattgg 1356781 cctgttgata ttgtgtatac tgcagtcacg ctggtaagtg tctggatgtt ggcttattat 1356841 attgatgaga aacagcagct ggttaagaaa atgaaggata acgaatggaa gtataaacag 1356901 ctttctgaag aaaaaaaccg catcatggat aatttgcagg aaatcgtatt tcaaacgaat 1356961 gcaaaaggtg aaattacata tttaaaccaa gcgtgggcat ctataaccgg gttttcaatc 1357021 agtgaatgta tgggaacaat gtataacgat tacttcataa aagaaaagca cgtagccgac 1357081 cacattaaca cccaaatcca aaacaaagcg tcttctggca tgtttacggc aaaatacgtg 1357141 acaaaaaacg gcacgatttt ttggggagaa gttcattata aactttacta tgaccgggat 1357201 gaccaattta caggcagcct gggtacaatg tcagatatca ctgagcggaa agaggctgaa 1357261 gatgagctca ttgagattaa tgaacggctg gcgagggaat cccagaaact atcaatcaca 1357321 agtgaacttg ccgcaggtat tgctcatgag gtcagaaacc ctttaacatc tgtcagcggt 1357381 ttcctccaga ttatgaaaac acaatatccg gacagaaaag actattttga catcatcttt 1357441 tcagagatta aaagaatcga tttagtgctc agcgagctgc tgctgcttgc aaaaccgcag 1357501 gcaatcacat ttaaaacaca ccagcttaat gagatcttga aacaagtcac gacattgctt 1357561 gataccaatg caattctgtc caatatcgtc atagagaaaa atttcaaaga gacagatggc 1357621 tgtatgatta atggagacga aaatcagctg aagcaggtct ttatcaacat cattaaaaac 1357681 ggaattgagg caatgccaaa gggcggtgtc gtaaccattt caactgctaa aaccgcctct 1357741 catgcagtga taagcgtaaa ggatgaagga aacggcatgc cgcaggaaaa gctgaagcag 1357801 attggcaaac ctttttattc aacaaaagaa aagggcactg gactgggact tcccatttgt 1357861 ttgagaatcc tgaaggaaca tgacggggaa ttgaaaatcg aaagtgaagc tggaaaaggc 1357921 agcgtctttc aagtggtttt gcctttaaaa tcagacagct gagaggagaa aaataaagtg 1357981 aactcgcttc tgtttgtata cgggacatta agaaagcatg aaaaaaacca tcatttgctg 1358041 gcacaatcgg catgtatcaa tgagcaggcg agaacaaagg gaagtttgtt tgctgcaaaa 1358101 gaggggccca cagttgtttt caatgatgaa gatgaaggct atatatatgg cgaagtatat 1358161 gaagcagatg aattgtgtat acataagctc gatcaatttt ttcaaggata tcataaacaa 1358221 acggtgtttg tagaaacgga tgtcgggatt aaaattgcgc ttatttattt tatgaacaaa 1358281 gacgggtgtg ccggttttac gaaaataagc agcggcgact ggaaagaaca tcagatgatc 1358341 agcaaatcga aaaatcccat ttattatttt gcctatggat catgcatgga taatgcccgc 1358401 tttcaaaaag cgggagtcga tcactatttt caagatccag taggaagagc tgttttaaaa 1358461 ggatacacaa cccgcttcac gctaaaaagg gaagacggtt caagagcgga catgttggaa 1358521 gacggaggaa caacagaagg cgttttatac cgtatccctt attctgctct ctcctatcta 1358581 tataaaaggg agggcgtcga atctcttacg tatcggccgg catttgtaga cgttgaagct 1358641 ggcggaaggc actacaaaga ctgtttaacc tttctcgtcc tccaaaaaga agcggaaatt 1358701 gccccgcctc agcactatca gattgaaatc gaacgcggag cggagctgta tttgtcgcct 1358761 gagtttactg aaaagctcaa gcggcatatg aattcgctgc caaaaggata acactgtaac 1358821 aaaagaatat gataaaattt gatcaatatc atgtcatata aaggagcacc acgatgaaaa 1358881 aagaatttgc ggtaattggg ctgggccgtt ttggtggcag tatttgcaaa gcattaagcg 1358941 aagaaggcgt cgaggttatg gcaatggata tcgatgaaga taaagtcaac gagtatgcca 1359001 agattgcatc tcacgcagtt atcggtgatt cgacagacga atctgtcctg aaaaatttag 1359061 gcctgcgaaa ttttgaccac gttattgtag caatcgggga aaatattcaa gcgagtattt 1359121 taacgacact cattctgaaa gaacttggcg tccatacgat tacagttaaa gcgcagaacg 1359181 attatcacga aaaagtgctg tctaaaattg gtgcggatca catcgtccac ccggaacgcg 1359241 atatggcaaa acgaattgcg cataatatcg tgtccaacaa tgtacttgac tatttggagc 1359301 tgtctgaaga gcatagtctt gttgaaatcg tagctaacag ccgcctggct ggaaatacgc 1359361 ttctcgattt agatattcgc gcaaaatacg gtattaacat cgtagccata aaaaggggca 1359421 aggaagtcat cgtatcaccg cttgcaaccg aagtcatcca ccaagaagat atactcattg 1359481 ttattggatc agttacagac atctcccgtt tcgaaaaaag agttcttcat acaaaatagc 1359541 agccaaataa gccgtcctca aagggcggtt tttcatatta tcagaatata acaactttaa 1359601 tgaactgagc gtcaatttct taaaatttca ttgactaagc acaggcgttc cgatagcata 1359661 ttgtaccata taataaaaaa aggaggggcc tatttgaata aagaagcgct agtcaatagg 1359721 ctgaatgctt cagccaaaag acaaaaagct gatatcgtca ttaaaaacgg aaaaatcatg 1359781 gacgtatata atcaagaatg gatatatgaa gatattgcga ttacagatgg agttattgta 1359841 ggcctcggtg agtatgaagg cgaaaatatc attgatgcag agggacaaat gattgttccg 1359901 ggttttattg atggacatgt acatattgag tcgtcaatgg ttacaccgat tgagttcgct 1359961 aaagcagtgt tgcctcatgg cgtgacgacg gttgttacag atccgcatga gatcgcgaat 1360021 gtgtctggtg aaaaagggat tgagtttatg cttgaacaag ctcggcatac accgctgaat 1360081 atccatttta tgcttccttc cagtgtgcct gccgcaagtt ttgagcgatc aggcgcaatt 1360141 ctcaaagctg ccgatctcaa gcctttttat gaagaagaag aagtattagg gctggctgaa 1360201 gttatggatt atgtgtcggt tcagcaggct gaaaaagaca tggttcagaa actgcttgat 1360261 gcccgtgtgg caggaaaaag gatagacggt catttagctg gtttatcaac agacctcatt 1360321 aacatttaca gaaccgcatt tgtcttaaac gaccatgaag taacatcgaa ggaagaagcc 1360381 cttgatcgta tcagaagggg catgtatgtc atgatgcgtg aaggatcagt cgccaaaaac 1360441 acgctcaatg tgctgccggc ggtgaatgaa aagaacgcac gccggttctt tttctgtacg 1360501 gatgataagc atgtggatga tttattgtca gagggaagtg taaaccatca ggtgaaaatg 1360561 gcgattcaag ccggacttaa tccgttttta gcctatcagc taggaagcct caatgcagcc 1360621 gaatgctacg gattagatac aaagggagcg attgccccgg gttttgacgc tgatttgctt 1360681 tttgtatctg atctggaaaa tgtcactgtc acaatgacga tggtaaaagg gcagactgtt 1360741 gctgaagaca gcaaagcggt ctatcaggat catgcttcaa ctgcagcacc agatcaggca 1360801 ctgcttgatt ctgttaagct tgctgctcct cttaacaaac aggattttca tatgccaatc 1360861 gattcagagc agcagatcaa tgtcattcaa atcataccaa atcagcttga aacacgatta 1360921 gtacaagttc cggctcctgt tgcccgcgaa tttgagcctg acactgagct tgatttgtta 1360981 aagattgcag ttgtcgagcg gcataaagga ttaaaagaaa ccggacttgg tgttgtgaaa 1361041 ggttttggat tcaagagcgg agcgattgcc acaaccattt cacacgactc ccataatatt 1361101 attgccgtcg gaacgaatga tgaggatatc gcggcggcag ttaataagct gcaggaaatt 1361161 ggcggaggat taacaattat aaaaaatggg gaagagctcc attcagtacc gctgccgatt 1361221 gcagggttat tatccgacca atctgcagag caagtgaatc aaagcttgct gacgcttcat 1361281 gataaattgt cgttaatcgg tttcacaggc ggatttaatc catttttgac attgtcgttt 1361341 ttagcgttgc ctgtcattcc tgatattaaa atgacgacta cgggattatt cgatgtaaaa 1361401 tcatttcaac acatatcact gcaataaaaa gaggcactcc cttagggagt gcctcttttt 1361461 ttaaacctcc ataatgatcg gcaggatcat tggacggcgc tttgtttttt cgtacaagaa 1361521 aggtgcaagc gtgtctgtaa tttcgttttt gatttcagac cattgagtcg tttttcgttc 1361581 cattactttt tgtaagtgat ttgaaatgag ctcttgagcg tcgttgatca agtcaccaga 1361641 ttctctcatg tacacaaatc ctctggaaat caaatcagga cccgctgaaa tcttgaagtc 1361701 gtccatgtca atgctgacaa caacgatgac aagtccttct tcagagagaa ttctgcgatc 1361761 acgaagtacg atattgccaa tatcaccgat accgcttccg tcaatgtaca ctgaaccgga 1361821 cgggattttt cctgcaactg aagcctcatc gcctttaagt gctaatactt caccattatc 1361881 catgataaag cagttttcct ctgggatgcc acaatctgtt gcaagtttga catgcatctt 1361941 ttgcattctg tactcaccgt gaatcggcat gaagaattta ggcttgatta aacgaagcat 1362001 cagcttctgt tcttcctgtc cgccgtgacc ggatgtatgg atatcgttaa gagggccgtg 1362061 aataacctca gcacccgcac gatacagctg gttgattgtt cgactcacgc tgattgtgtt 1362121 gcctgggata ggggatgaag aaaatacgac tgtatcccca ggattgattg aaatttggcg 1362181 gtgtgtgccg tttgcaattc ttgataacgc cgccattggt tccccttggc ttcctgtaca 1362241 taaaattgtt actttattag caggcatacg attgatttcg ttatgctcaa taaacgtatt 1362301 tttaggacag ttaatataac cgagtgtctg tccaatttcg atagccgatt ccatactgcg 1362361 tccaaatacg gcaacttttc ttccattttg tacagcagct tcaattacct gctgcaagcg 1362421 gtgaatattc gacgcaaatg tggcgaagat aattcggccg tccaccttgc ggaaaatgtc 1362481 atgaatgctt tctcctacac ggcgctcaga catggtaaac tccggatttt cactgtttgt 1362541 gctgtctgaa agaaggcaca aaacgccttc tttaccgatt tcggccattt tcgttaagtt 1362601 tgccggctcg ccgactggag taaagtcgaa tttgaaatcc ccagtatgta cgatgtttcc 1362661 gggcggcgtt tttacaacaa tgccgtagga atccggaata ctgtgtgttg ttctgaagaa 1362721 tgacacagcc gttttgcgga actttacaat atcatcctcg ccgataatgt tcagtttcgt 1362781 ctgtctcaat aatccatgct cttcaagttt attccgaagt aagccgatcg cgagttttcc 1362841 gccgtataca ggaatattca cttgtctgag caggtatgga ataccgccga tgtggtcttc 1362901 gtgcccgtgg gtgataaaaa gccctttaat tttatcttcg tttttgacta aatacgtata 1362961 atcagggatg acgtagtcaa ttccgagcag ttcgtcctcg ggaaacttga tccccgcatc 1363021 aatcagtaca atttcatcct ggaattgcac cgcgtacgta tttttaccga tttcgcccaa 1363081 acctccgagg gcgaaaacag cagtctgatc attttttaca aatttcatac cgctcataac 1363141 tccaatactt taaaattttc gctctgttgt tcatattcta agaatgcacc atcaacaggt 1363201 gtaataaact caatattaaa tttcttttct ttcagctttg ttctgacgtc acgctcagat 1363261 acgccttcaa tataaagtga atctgtcttt tcccgaacag gtacttcgtc agccttctct 1363321 tgataaaata ccttataaat cattccaaat ctctccttaa atgccgtatg ttagactcgc 1363381 tcattctatt atattcgaaa acggaatata aggaaagcct tgagcaaaat aaggatctct 1363441 caaaaagtga aagatccctt gtcaggcaat tgctttctta cggagcattc cgttccattg 1363501 tcttctgagt ttctttctta atttacgcag cattagccag tccctccttt aatgaaaaat 1363561 ttgtcccaga gttcttttat acaaatagta tacggagatt gaggaagact tttcgtggtt 1363621 attaatggaa tttaatatga tttttgaacg aaattgtttg ctgaatgaca atctttttgt 1363681 atgatgaggg tgggaattgc agaccaagac gataaagggg aagttgcgat ggattctaaa 1363741 ttaatctttt ttgatattga cggcacaata tatgatcatg ataagaatat accggaaagt 1363801 acgagaaaaa ccgtggcgga gcttcagcgc caagggcatc atgtgtttat tgccagcggc 1363861 cggtctccat ttttggttaa gccgattttg gaggagctgg gcatccactc atttatttcc 1363921 tacaatggac agtttgttgt ctttgaaaat caagtgattt ataaaaatcc gctgcctgaa 1363981 aatgcaatca ggcgattatt aaagcaggcg gatgaaggca agcatcctgt tgtgtttatg 1364041 gctgaggaca cgatgaaagc gactgttgcg gatcaccccc atgttctcga gggaatcggc 1364101 agccttaaaa cagattatcc agagaccgat gacctttttt atgaaggaaa agaaattttt 1364161 cagcttcttt tattttgtca ggatgaagaa gaaaaagctt atgccgcttt tcctgagttt 1364221 gatctagttc gctggcatga gctatcgact gatgttctgc cgcacggagg ttcgaaggca 1364281 gaaggaatca aaaaagtgat tgagcgtctt ccgtttgata tcggcgatac atatgctttc 1364341 ggcgacggat taaatgattt gcaaatgatt gaatacgttg ggacaggcgt tgctatggga 1364401 aatgctgttc ccgaactgaa agaaatcgcg gactttgtaa caaaaccggt ggacgaggat 1364461 ggaattgcat acgctgtcaa agaattgggc cttttaaaat aaagaaacgg ctggcattgt 1364521 gccagccgtt ttctctttta gcgctcaatt gcgattgcat tttcaggttc tttgaaagga 1364581 ttttccttat caatatgatc atagaacata acgccgttca aatgatcgat ctcatgctga 1364641 aacacaatag ccggaaatcc ttttaaacga atatcaatat tttcgccttc tagtgttgtt 1364701 ccttttactc tgatgcgagc atagcgggga acataaccgg gaatcgcttc atccacagag 1364761 aggcagccct cgccgcttgt taagtagctt ttttcaactg aatggctgac gatcttagga 1364821 ttaaacagag catagctgta taatttaccg gaagcatctt ccgcatgaac ggcgatcatt 1364881 cgttttttga tattaatttg aggagctgcg agtcctacgc cagggcgcag cttgtatttt 1364941 tcggctaatt ctggattttg gctgttttta acaaattcga tcatgtcggc cagctgctgt 1365001 ttttctgcat cagttggagg cagctcaaca ggttcggcag tctctctgag ggctggatgg 1365061 ccgtcacgta cgatgttttc catagtaatc aagaaacttc actcctaaag cttaatatgt 1365121 aaattatatc ggatttcttc acaaaggtgc aacgaaacga atgaccagcc gtatatggct 1365181 ggtcaatttc atgctgtgtg gttagcaaca gcctccacct aaataagcag ctccgacaat 1365241 gattaacaga atgaataaaa caacgattag cgcaaaggtg cggccgtagc catatccgca 1365301 gccaccatat ccgtaaccac cataactgca gcagcctccg ccgtaaccat atccatacat 1365361 attacataac ctcctctttt aattacgcca gagcctttat aagtaggcat agcgtctaat 1365421 ataacctatg taaaaacaaa aaagttgtat ggtcatctgt cctgattttt cacttttttg 1365481 atttaatttc agtattgcat ttatacagca cggctattgc caaatgtccc catggattct 1365541 atagtagaaa ttgtcaagat tgggggattt aacgtgaaag acgctataaa acggcggcct 1365601 ggaatcaaga tcggagcttt ttgtgccatg gcactgatat taacaggatg catgggacag 1365661 gacccggttg attcacttca tcattcatta gaaaaagccg cggaatcgga aaagccgttt 1365721 caagaagaac aaaacacact caaagaatta gaggccaaag aaaatcagct ttacgatagt 1365781 gttatgaagc tcaatatgga tgattataaa aaaattgttg ctttatctaa taaggcgctt 1365841 gaaaatgtca gcaagcgcga agaacaccta aagcttgaaa atgacagcat gaaaaaatcg 1365901 gaaacagaat ttgaggaagc aaaaacgtca gcggaacata ttaaggaaaa agacataaaa 1365961 gaaaaggccg atgccgcagc aaaccatatg gagaaaagat atacatcata tggcactatg 1366021 tataaagagt ataaaaaagc gcttgagctt aataaaaaac tgtatatgca gctgaaagac 1366081 aaagatttga caagagatga tctggatcag cagatcgata aagtcaatgc ttcttatgaa 1366141 aagatcctta aatatagcgg agaatttaat gaacaaaccg aaaaatataa taaagcccgg 1366201 gaagatttat atgatgctgc aggctatcgt gtgaaaaaga gctgactcga tcagctcttt 1366261 ttttgaatga aatgcgattc ggatttcgtt caaaattttc atttctattg tagtacagca 1366321 tagtaaggta tactagtaca gttttgggtg cggttggcat ctgttttttt gatgaaaatg 1366381 taaagcgaat acatttattg aaaatcagcg atgaaaacga ttgacggttc ttctttattt 1366441 ggtgtaaact aatccatgtt aagcggtgtt gtattagttt tttacaactt cgaaataata 1366501 cagttcaaag cagagtgtaa ctatcctaca taaaaggttt tggcaaactg gggatcggct 1366561 aaaatataat acgacttact gctgatactt tagggtaccc taagtttgta tgtataaaag 1366621 gaatgcacgt ctaatgactg tttaaaagaa aggaagaggt gacttagtat ggctgcaaaa 1366681 acgaaaaaag ctatcgttga cagtaagaag caatttgatg ccattaaaaa gcagttcgaa 1366741 acgttccaaa ttttaaatga aaagggagaa gtcgtgaatg aagcggcgat gcctgattta 1366801 actgatgatc aattaaaaga gctaatgcgc cgcatggtat ttacgcgtgt gcttgaccaa 1366861 cgctctatct cattaaaccg tcaaggacgt ctcggatttt acgctcctac tgcgggtcaa 1366921 gaagcttctc agattgcaac gcatttcgcg cttgaaaaag aagactttgt tcttcctgga 1366981 taccgtgatg tgcctcagtt aatttggcac ggccttccat tatatcaagc gtttcttttc 1367041 tctcgcggac atttcagagg aaaccaaatg cctgatgatg tgaatgccct ttctccacaa 1367101 atcattatcg gtgctcaata cattcaaact gccggtgttg cgctaggtct taaaaaacgc 1367161 ggtaagaaag ctgtcgcaat cacttacact ggtgacggcg gagcttctca aggggacttc 1367221 tacgaaggaa ttaactttgc cggagcttat aaagcacctg caatcttcgt ggtgcaaaac 1367281 aaccgttacg cgatttcaac tcctgttgaa aaacaatctg cagctgaaac aattgcacaa 1367341 aaagctgtag ctgccggtat tgtcggcgta caagtagacg gaatggatcc gcttgctgta 1367401 tacgcagcaa ctgctgaagc acgcgagcgc gcaatcaacg gcgaaggtcc aacactaatt 1367461 gaaacactta cattccgtta tggcccgcac acaatggctg gtgacgatcc tactaaatat 1367521 cgtacaaaag aaatcgaaaa tgagtgggaa caaaaagatc cgcttgtacg tttccgtgcg 1367581 ttccttgaaa acaaaggctt atggtctgaa gaagaagaag caaaagtgat tgaggatgcg 1367641 aaagaagaaa ttaagcaagc gatcaaaaaa gctgatgctg aaccgaagca aaaagtaact 1367701 gatttaatga aaatcatgta cgaaaaaatg cctcacaacc ttgaggagca atttgaaatt 1367761 tatacacaga aggagtcgaa gtaagccatg gcgcaaatga caatgattca agcaatcacg 1367821 gatgcgttac gcacagaact gaaaaatgac gaaaatgtct tagttttcgg agaagacgtt 1367881 ggtgtaaacg gcggcgtatt ccgtgcgaca gaaggattgc aaaaagaatt cggtgaagac 1367941 cgtgtgtttg acacgccact tgctgaatct ggtatcggcg gtcttgccct tggtttaggc 1368001 ttaaacggct tccgtccggt aatggaaatc caattcttcg gatttgttta tgaagtaatg 1368061 gattcagttt ctggccaaat ggctcgtatg cgctaccgtt ctggcggacg ctggacttca 1368121 cctgtaacaa ttcgttctcc attcggcggc ggtgttcata ctcctgaact tcacgctgac 1368181 agcttggaag gtcttgttgc acaacagcct ggtatcaaag ttgttattcc atcaactcct 1368241 tacgatgcca aaggactttt aatttctgcg atcagagaca atgatcctgt tgtcttctta 1368301 gagcatatga agctttaccg ttctttccgt caggaagttc ctgaagaaga atacacaatt 1368361 gagcttggaa aagctgacgt gaaacgtgaa ggtactgatc tttcaatcat cacttacggc 1368421 gcaatggttc atgaatcatt aaaagctgct gatgagcttg aaaaagacgg catttctgct 1368481 gaagttgtcg accttcgtac agtaagccca cttgatatcg atacaattat cgcctctgta 1368541 gaaaaaacag gacgcgcgat tgtcgttcaa gaggcacaaa aacaagccgg tattgctgca 1368601 aacgtagtag cagaaattaa tgaccgtgcg atcctgagct tggaagcacc tgtacttcgc 1368661 gttgcagcgc cagatacagt atttcctttc tctcaagcgg agagcgtatg gcttccaaac 1368721 cataaagacg ttcttgaaac agcaagaaaa gtgcttgaat tttaatcaaa ctgcataatc 1368781 gagagggaag atgaacgttt tccctctatt atatatctgt tttcaatgct tacgatgtaa 1368841 actttaaaat tgcttaatca aactaggagg tcgagaactg tggcatttga atttaaactt 1368901 ccagatatcg gggaaggtat ccacgaaggc gaaatcgtaa aatggtttgt caagcctaac 1368961 gacgaggtag acgaagatga tgtactggct gaagtccaaa atgataaagc agtagtagaa 1369021 attccttcac ctgttaaagg aaaagtatta gaattaaaag ttgaagaggg aacggttgca 1369081 actgttggac aaacgattat tacgtttgat gcacctggtt acgaagatct tcaatttaaa 1369141 ggcagcgacg agtctgacga tgcgaaaact gaagcacaag ttcagtcaac tgcagaagct 1369201 ggacaagacg ttgcgaaaga agagcaagct caagagcctg caaaagctac tggcgcagga 1369261 cagcaggatc aagctgaagt tgacccgaac aaacgcgtga tcgctatgcc ttccgtacgt 1369321 aaatatgcac gtgaaaaagg tgtagacatc cgtaaggtta ctggttcagg caacaacgga 1369381 cgtgttgtaa aagaagatat cgacagcttt gtaaacggag gagcgcaaga agctgcaccg 1369441 caagaaacag ctgcaccaca agaaacagct gctaaaccgg ctgctgcacc agctccagag 1369501 ggcgaattcc cagaaacacg cgaaaaaatg agcggtatcc gtaaagcaat tgcaaaagcg 1369561 atggttaact ctaaacacac tgctcctcac gtaacgttaa tggacgaagt ggacgtaaca 1369621 aaccttgttg cacatcgtaa acagttcaaa caggttgctg ctgatcaagg aatcaagctg 1369681 acttacttgc cttacgttgt aaaagctctt acatctgcac tgaaaaaatt ccctgtttta 1369741 aacacgtcaa ttgacgataa aacagatgaa gtcatccaaa aacattactt caacatcggt 1369801 atcgctgctg acactgaaaa aggcttgctt gtaccggttg tgaaaaatgc agatcgtaaa 1369861 tctgtctttg aaatttctga tgaaatcaat ggccttgcaa caaaagctcg tgaaggcaag 1369921 cttgctccag ctgaaatgaa aggcgcatct tgcacaatta caaacatcgg ttctgccggc 1369981 ggacaatggt tcactccggt tatcaaccat ccagaagttg cgattcttgg tatcggacgc 1370041 attgcagaaa aagcgattgt tcgtgatggc gaaatcgtag cagctccagt cttagctctt 1370101 tctctcagct tcgaccaccg tatgatcgac ggagcaactg cgcaaaatgc attaaatcac 1370161 atcaagcgtt tactgaacga tccacaatta attttaatgg aggcgtaatg ttatggtagt 1370221 aggagatttc cctattgaaa cagatactct tgtaattggt gcgggacctg gcggctatgt 1370281 agctgccatc cgcgctgcac agcttggaca aaaagtaaca gtcgttgaaa aagcaactct 1370341 tggaggcgtt tgtctgaacg ttggatgtat cccttcaaaa gcgctgatca atgcaggtca 1370401 ccgttatgag aatgcaaaac attctgatga catgggaatc actgctgaga atgtaacagt 1370461 tgatttcaca aaagttcaag aatggaaagc ttctgttgtc aacaagctta ctggcggtgt 1370521 agcaggtctt cttaaaggca acaaagtaga tgttgtaaaa ggtgaagctt actttgtaga 1370581 cagcaattca gttcgtgtta tggatgagaa ctctgctcaa acatacacgt ttaaaaacgc 1370641 aatcattgct actggttctc gtcctatcga attgccaaac ttcaaatata gtgagcgtgt 1370701 cctgaattca actggcgctt tggctcttaa agaaattcct aaaaagctcg ttgttatcgg 1370761 cggcggatac atcggaactg aacttggaac tgcgtatgct aacttcggta ctgaacttgt 1370821 tattcttgaa ggcggagatg aaattcttcc tggcttcgaa aaacaaatga gttctctcgt 1370881 tacacgcaga ctgaagaaaa aaggcaacgt tgaaatccat acaaacgcga tggctaaagg 1370941 cgttgaagaa agaccagacg gcgtaacagt tactttcgaa gtaaaaggcg aagaaaaaac 1371001 tgttgatgct gattacgtat tgattacagt aggacgccgt ccaaacactg atgagcttgg 1371061 tcttgagcaa gtcggtatcg aaatgacgga ccgcggtatc gtgaaaactg acaaacagtg 1371121 ccgcacaaac gtacctaaca tttatgcaat cggtgatatc atcgaaggac cgccgcttgc 1371181 tcataaagca tcttacgaag gtaaaatcgc tgcagaagct atcgctggag agcctgcaga 1371241 aatcgattac cttggtattc ctgcggttgt tttctctgag cctgaacttg catcagttgg 1371301 ttacactgaa gcacaggcga aagaagaagg tcttgacatt gttgctgcta aattcccatt 1371361 tgcagcaaac ggccgcgcgc tttctcttaa cgaaacagac ggcttcatga agctgatcac 1371421 tcgtaaagag gacggtcttg tgatcggtgc gcaaatcgcc ggagcaagtg cttctgatat 1371481 gatttctgaa ttaagcttag cgattgaagg cggcatgact gctgaagata tcgcaatgac 1371541 aattcacgct cacccaacat tgggcgaaat cacaatggaa gctgctgaag tggcaatcgg 1371601 aagtccgatt cacatcgtaa aataattttc atatcaaaaa cagccccgct ttgagcgagg 1371661 gctgtttttt tattttgaca gcacatgctg taatggttta atgatgtctt ctttcttttt 1371721 cacacatccc tcgattttca ccacgacatg gcgctgatca acaaccataa gggtagggac 1371781 agtttcaatc tcatcttccc agccttcttt tttatcatag accttcattt tatctatttg 1371841 ctcgggataa tctttttcta aatcaagcag tgcatcgtaa taaggcgctt cctggtctat 1371901 ttggttctca tcagaaaaaa acaggatttg tgtatgatga atgttgtcaa tccggctttt 1371961 tttcatcgga ttgatggtgg aaagcgtaca gcccgataaa gcaaatacta ttatcagcat 1372021 ggggaatacc gcgcgatatc gcatctatct tctcctctgt ataaacagta gttaactagc 1372081 tttagtttat cacgagagac ggcttaatct gcttcttgtt acctaattgt tatataattg 1372141 aaaccgtttt taaagtgaga ttacatatta tatcaatcgt ttaaaatagc aacctggggt 1372201 atattgaatt ttttgctgca ttcttggatg aaagttcaag aaaacgtgca attacattat 1372261 gtgctgtggc atatatatcg agtaaagctt ctgtatgaag aagatattgt atgatggaaa 1372321 atggaaaaac aaggtgaata tgatgatatg aaataaaatg tgttatacag tttgttgttg 1372381 acattttaaa tgtgacatat taatataata acaacaaaag aaattaagcg ttttcaaatt 1372441 tcaaagaaat ggggaataag agatgggtac gattgtttgc caagattgca acgaagccat 1372501 tcattacttt gaagatgaga aagtgacaac attatatgga acttgctgcg gacaatgtca 1372561 atgtcctgtt gatgaagagt aaaaaaaagc atgcggctta aagccgcatg ctttttattt 1372621 tttattgaat tgctttttgt tctttgatga cccggatcat atgtaaagtc gagtcctcag 1372681 gtccttgaac agggaggcct gcgtcaaggt ttttaaaaat gtagctgatg ttttcttctg 1372741 taataatttc tcctgggatg aagattggaa taccaggcgg atataccatg acaaattcag 1372801 caataatccg tccggatgct tcttttaatg ggatgacttc cgtatttgca tagaaagcat 1372861 cacgcggagt cattgccaat aaaggtattt ctggaagcag aacctcagtt tgctgatgtg 1372921 ttacatcttg ttctgacatt tgctgtgcga tctcagttaa agcctctaca agccggtctg 1372981 catcattttg gctgtcacca ggagtgaaaa tacacaaaat attgtacaga tcagaaagct 1373041 ccacctcaat attaaaggat tcacgaagcc atttttccac gtcatgtcct gtcaggccaa 1373101 gacttttcac agagataatc aattttgtcg gatcatagct gtaagctgct ttcgacccaa 1373161 gaatctcaga accgacacaa taaatgcctt caatctgatt gaggcgatct ctcgtctgat 1373221 tggcaagctt gagtgtttcc tcagcaagct ggcggccttc tgttgcaagg cgttttctgg 1373281 caacatccaa agaagcgaga agcaagtaag aagttgacgt agttgtcagc atgctcagga 1373341 tggattgcac tctgtcttta gatacaaggc cttctctcat gtttaaaata gagctttgtg 1373401 tcagtgatcc gcccagcttg tgtacacttg tcgctgctat gtccgctcct gcctgcatag 1373461 ccgatagcgg caattcgtcg tgaaaatgaa tgtgaacgcc gtgtgcttca tccacaagca 1373521 ctggcacatc aaacgaatga gcgagttcta cgatgctttt taagtcggct gcaacaccga 1373581 aatatgtcgg gttgatgacg agaagccctt ttgcatccgg atgctcggta agcgcccgtt 1373641 tagcagattc aagtgtaatt ccgtgggaga tgcccaattc attgtcaatt tcaggatgaa 1373701 taaaaattgg aaccgctccg gaaaatacaa tagctgtcat aattgattta tgaacatttc 1373761 ttggaataat aattttatca ccaggtccgc aaacagccat taccattgtc ataatggcgc 1373821 cgcttgttcc ttgaacagaa aaaaatgtat gatccgctcc aaatgcttca gcagccagat 1373881 cttgtgcttg tttaataatg ccttttggcg cgtgcagatc gtctaatggt tcaatattaa 1373941 tcaaatctat gcttaacgcg ttttcaccga taaattgtct gaattctggg tccattcctg 1374001 cccctttttt atggccggga atgtggaatt gaacaggctg tctgcttgca tgctttttca 1374061 gtcctgtgta taagggtgtt tcatgttgcg acaattgttt tcccaccttt gtaatcatac 1374121 ctatgcataa tagtgtgtat taaaatcagt ttctcaaccg ttttttagac gtaaaacaaa 1374181 tgaattatat tatgaacttg aaagaatgta aagctagaca aaattgatag tattgtcctg 1374241 tgtttgtttt tgttgaataa tatcaagatg agtcaagtgt catgtggtgg ttcattcaag 1374301 agttatgttt tttacatatc aaggggaaga tgagatattt ttgtttcatc ttgaaacttt 1374361 ttgaaaagtc cgctgtctaa ccgaatgagg ccttaataag aagtaaagga ttgttgttcg 1374421 tgttggagtt attcagtcat tatgtattgc atttcgaacg ttattttata ttaagcagac 1374481 aaagcaccct gctgattcaa tggtcaattg ttgttctggc gggcttatat cttttggtgc 1374541 atcatcccaa aataaaccgg cagcgcacaa tgttcttggc gggtgttata ttgcggattg 1374601 tgctgctggc gggagtgtct gttgaactta ttcaccaggt gcaatcaaca aacttcacca 1374661 gcgcttactt aagagaggac ggaaaagaac tgctgccgct gctgcatttt ttgttatacg 1374721 gatatgtgct gctgacggct tttcactata tgctgatgcc gcgtgatcat ggcggaaagg 1374781 gtaagtttta tacgttcgac cttgctgttg tcagtttgcc gatcgtacaa atgattttta 1374841 gtttcttttc gtattggaag gaatacccgg atgggatgga gccgattgca ttcgtgtttc 1374901 tgtttttcat catcactctt cccattgcgt tgaatgtagt gtttttcaag ctgtattgga 1374961 gaacggataa gatcttacta ggcttatttt atacgctgat tatcggactg cttgtcttgc 1375021 tgcttgcgcc atatcccaat caaatctcaa aagattatgg tgcagtaatg ccatatacga 1375081 tttatttggc aatggcggga tttttgatga gctatcatct gttccaaaag tcaggaaagg 1375141 tttatgtgcg tgtgaataag tgggtgacga tggctgtcat ggtgtttttt gtcctgctgt 1375201 taaatccgat atataacata ggaacggctg ctttcgctgt atcaaagcca gcaaatgtcc 1375261 atgattcatt caattttgtc ggggagcaca tttcatcaga aaaagcggaa cagatactaa 1375321 agtcattttt tcctacggat gaaacacttt atttgcacga tacaaacatg gatgtgcatt 1375381 atttctactc atttgaaagc aaaggttaca aagctgaggt agatgaagta tcgcagctaa 1375441 ttcgtaatta tgaatactta caaaaagcac atgggaaaaa gctaacgaat caggagtaca 1375501 agcgaaagtc catcgctttc cttgagcgac acggacgtgt gttacataag gatcatatcg 1375561 aaacaaaggt atctcaagaa gacggccaga cagtcgtacg tatttacctg aaaaatcaac 1375621 ttcataaaaa agatcatgct gatgatggcg cggtatttta ttgggaaaag gaaaccttaa 1375681 tggggtttag tgaagatcct tcgatttatc agcttgactc tcttctgcat gttcatataa 1375741 cggaacaaga cattcacgac aaagtggaac aaatgtttac agcgctgaac atatcaaaac 1375801 agccttatca gatcactgat attgaaagcg acagcctgct tggaagcatg gtgagagttg 1375861 aaacaaaagt tggaattgtt ttggaatttg agggcgaatc aggttgttta catagtcttt 1375921 cgcttccgat gaaaaagaat atctcaatgg ctaacagccg gctgcagcat cagatattat 1375981 cgatcttcga tgctcgtgga tcagaaaaga agaaaaaaag cagtcagggt gacatggtga 1376041 tgtatactga ttcttctaaa acatatgagt ttgttgaagc tcaaggtcag ctaaacgttt 1376101 atgtatacag cgatacacct gatcagtcat tcccctatac gtatcgtaat ggaacattgg 1376161 cttacgaaaa agtagcttct ctatatcagg atgtcattta caaaaagcgt atgcgtccga 1376221 ttatcgttca aagaggggat gaacggcatt atgcatggct gatcattatt cagccgtttg 1376281 gttcaaatcg ccatgatgcc tatgtagtgg atggagaaac acaagaggtg aaaagtcttt 1376341 atgaatcata aagaaaaaga gtctgttttt gtagacttat acgacctgta taaagaagga 1376401 gagctagagg atgaatcaat ggaatggatg aaacagcatg aatccctatt tcaaaagaat 1376461 gcggaagact taaagagtaa aacttgttta aagagaagtc ccggtgctga agaagaaagc 1376521 caaatcagat atatgaaagt atacctgtct tccatgtata tctgtttcat tttattggcc 1376581 atttggatga cggtgtggtt ttatttttaa tgaagcatag ggattccatt gaggacttgt 1376641 atcggcagta ttatcaagaa attttaaatt atttattcag aaggactcat catcttgaaa 1376701 cagccaagga cttagcgcag gacacgtttg taaaagctct taacggtctg gcttcgttta 1376761 gggggcattc ttccatcaga acatggctct acaccattgc gcatcatacc tttatcaatt 1376821 ggtaccgaag ggatgtcaaa taccaattta ctgaaatcag caaaaatgaa gggttaacgc 1376881 aaacaactta tgaccagcct gaacagtatc tgtcacggac ggtgaaaagc gaaacactgc 1376941 ggcaggagct cctgaagtta aaagatcagc atcaatccgt tttgatttta agagaattcc 1377001 aagagctttc ttatgaagaa atcgctgaga tattaggatg gagtctttct aaggtgaata 1377061 ccacattgca ccgggctaga ttagagctaa agaaaaacat gacgaaaagt agagaggagg 1377121 agcggatatg acctgctttc tagtaagaga cctgcttcct ctgtatcttg aaggtgattg 1377181 taaaagagaa acggaacacg ttatagaaga gcatttaaaa atgtgcagca gctgcagaga 1377241 catgtatgac acgatggctg agccatttga attggaaagc gaacaggccg ttgaggaggc 1377301 ttatctgccg gaagaagaac tgcgttttaa acagaggtac tatggattac tgatcatgaa 1377361 agctgcctgc tggtttggag cggcggttgc catgatgctg atcatcaaac tgctgatata 1377421 aaaaaagcgc ttgtccgatt ccggcaagcg cttttttaca ttaagcctgg ggatgaatca 1377481 tatcgtaaat agcggcaagc tgttcttgtg acagggcact gaagagtttt tcataaacgt 1377541 cagcttgcag tggcgttgca cctgcttgta gcgctgcgtc tttatcatag ctgtacacat 1377601 catcttgtag cacaatggct gcttgaagaa tgtgaatctt gagagaaaca gcggagaaaa 1377661 attgttcaag tgcaagtgct tctttttctg tgaagccaag ttcaactgct ttttctgtat 1377721 caaatttgta atttccatcc tcgagataca cacattgtga aacaatgctg aaaaattctg 1377781 atgtcgattc ccagagtgta gcaattacct gagcctcttc ttttgtcatt cctaactcga 1377841 cagctttttc gctgtcaaaa taatatacac cgtcttgttc gtatatacat tgatttaata 1377901 tatcaatgaa tgtattgaga tcttcgttag tgctcgcctg atgctggagt tgaacagcag 1377961 tgttatcaac cggtgttttt gcgctggctg catcaggacc gaacgttaat agagcagctg 1378021 aggtcattgc ggcagtcgtt aacatagctt tttttacaaa tgttttcttc atgtttcttc 1378081 tctccctttt atgaattgtg ctacaaattc cattataggg agtagtttcc ggtggaggaa 1378141 taggcgctat ggtattttat gtgtatcgtt gccgaactac tttttgaagg ctgcacgtgt 1378201 gatcgttaga acgattgtct atgtatgaag gctgttttgc atcttcctga ctaagaaaca 1378261 ggggagataa ggcttaaaga aatgaaaaac accgctttct ttgcggtgtt ttttgattac 1378321 aatgtcgccg gcggggcaat gcttttaatc aagcaagcct tgttcgcgca ttttcttttt 1378381 taatgtaaat ccgccgccca tgacagcgca aacaagtaca atgctggcga taatgcctgc 1378441 agggcttttt tcagcgataa agacgccgat cagcataatg ctgaaaaccg ctgcaaatgc 1378501 aaataatagt aaaagccaat tcattttttt cataaattcc atcccctttt acgtcttata 1378561 ttaagtttac agaaaaacgt gacgctttta aagaggatgt gtgatataat atgaaagtta 1378621 tctaattttt ttaggagatg aaaaagtgaa acttcgaaat gatcttcgca acatcgcgat 1378681 tattgcccac gttgaccatg ggaaaacgac tctagtcgat cagcttttac atcaggctgg 1378741 tacgttccgt gccaacgaac aggttgctga acgcgcaatg gactctaatg atcttgaacg 1378801 cgaacgcggc attacaatat tggcgaaaaa tactgcgatt aactataaag atacacgtat 1378861 caatattttg gacacccctg gacatgcaga ctttggggga gaagtagaac ggattatgaa 1378921 aatggttgac ggcgtagtgc ttgtcgttga cgcatatgaa ggctgtatgc ctcaaactcg 1378981 ttttgttctg aaaaaagctc ttgagcaaaa cctgaaccct gttgttgttg taaacaaaat 1379041 tgaccgtgac tttgctcgtc cagaggaagt tatcgatgaa gttctggatc tgttcattga 1379101 gcttgatgcc aatgaagagc agctcgagtt cccagtggta tatgcttccg cgattaatgg 1379161 aacagcgagt cttgatccga aacaacagga tgaaaacatg gaagctttat atgaaaccat 1379221 tattaagcat gttccggcac ctgttgataa tgcagaggag ccgcttcaat tccaagttgc 1379281 ccttcttgac tacaacgact atgtaggccg tatcggaatc ggacgcgtat tccgcggcac 1379341 aatgaaagtc ggacagcagg tttctcttat gaagcttgac ggaacggcaa agtcattccg 1379401 tgttacaaag atttttggtt tccaaggctt aaagcgtgtg gaaattgaag aagcaaaagc 1379461 gggagacctc gttgcggttt ccgggatgga agatatcaac gttggtgaaa cggtatgtcc 1379521 tgtagaccat caagatccgc ttccggtcct tcgcattgat gagccgacac ttcaaatgac 1379581 atttgtcgtg aataacagtc cgtttgcagg ccgtgaaggc aaatatgtaa cggcccgcaa 1379641 aatcgaagag cgtcttcaat cacagcttca gacggatgtg agcttgcgtg ttgagccaac 1379701 agcttctcct gatgcttggg ttgtttcagg acgcggtgag ctgcacttgt caattttaat 1379761 tgaaaatatg cgtcgtgagg gctatgagct tcaagtgtca aaacctgaag ttattatcaa 1379821 agaaatcgac ggcgtacgct gtgagcctgt tgaacgtgtg caaattgatg ttcctgaaga 1379881 gcatactggc tctgtaatgg aatcaatggg tgcccgcaaa ggcgaaatgg ttgatatgat 1379941 caacaacgga aacggccaag tccgtctcat ctttacagtt ccttcccgcg gattgatcgg 1380001 ttactctaca gaattcctat cattaacacg cggattcggt attttgaacc atacgtttga 1380061 cagctaccag ccgatgcagg caggccaagt cggcggacgc cgtcaaggtg tacttgtgtc 1380121 aatggaaaac ggaaaagcaa catcatacgg tattcaagga attgaagacc gcggtgtcat 1380181 cttcgttgag ccgggtactg aagtatacga aggaatgatc gttggagagc ataaccgtga 1380241 caacgacctt gttgttaacg tcagcaaaat gaaacagcaa acaaacgtcc gttctgcgac 1380301 aaaggatcag acaactacaa ttaaaaaagc gcgcatcatg tctcttgagg agtctctaga 1380361 gtacttaaac gaagatgaat attgtgaagt aacacctgaa tccatccgtt taagaaagaa 1380421 gatcctcaat aagaacgaac gtgaaaaagc agctaaaaag aaaaaaacag caggattgtc 1380481 ttaatctcgt gcagaatttg aaaagataga acccgtacgt ttacagggga gggaatcttt 1380541 ttgaatgacg taagcgaacg cctgtcgttc ttcgccgctc tatatcaagt agaccggcag 1380601 cctgcggcag gcatgtggct gctgtacggc acgatttttg tgttggccgt tattgtattt 1380661 aagcttggat ttgctaaacg gcttcctgta ttaaaatctg cagtggtgta tgtatttttg 1380721 gctttgggct gcactgtttt gactttttta ggggtgtttt tgcccgtggc agaaggattg 1380781 gtcgtcgctg cgctgatttt aatcatttac aaaatccggc tgtatcagtc gaaaaaagga 1380841 cagtctgcaa aatcataaaa gactcagctg aaagctgagt cttttttgtg ttctgtatgg 1380901 ttaagcggcc gctttatttt ttgacttttt cttttttctg ctgtcccggg tgaaaagtaa 1380961 attttcccgt tttcagccgt tcctctgttt ttttggcaat ccgatcgtgg cattcctggc 1381021 acatatatgt atggatcggg cggtttcgaa gccgtttcgc gatcagggta tcatcatcaa 1381081 ttgtttcaat tttatcgcaa atagaacatt tgaccctcat catatcacct ctttcactaa 1381141 catgtattat accacggatc agaagctgtc caaaataaga aaaagctaaa gcgcaaggct 1381201 atagcttagt cattgttgtt ctttttcata tgatgatcag attgatcgtt ttgttccttc 1381261 tccatttcct gttgctgttt tctatttaat tggtcatttt gctgctttgt ttgcggttca 1381321 tcttcattgt caatcacatc gttaggcact tcgggaagca ctcggccgac aattgcagct 1381381 aattcatcca gtatacctgt taccggatgg ccctcgctga tttctctgct catttcgcga 1381441 aggcggctga ccgtatcggg atcagcaatg actactgcgt tggcgccata tcgatcattc 1381501 tttagcgcct gagctacaga atatttaatg gtttccactt tgcttctgtc caaagtatca 1381561 tcgacatcaa tcccaacaac agcatagcct cccagcacaa cggctgttgc atccttgacg 1381621 tcggggtttt tttcagcaac gctgacaaga tgcttggcaa tatccgttct tgttccattg 1381681 tcttttgttt cttgagttgt gtcctttacg tgaatcggtt tagtctcctg ctgtcttgtt 1381741 gattcttttt caacattctg gccctgtttt ccttgttgat aggcacaagc ggacaggata 1381801 agtgtcagct gtatgataat gaaaagaatt cgcacttgcg ggttccctcc ttaaaatgct 1381861 ttcattaatt ttattgttga attaaccttc tatctttatg cacaaaaaca tatattttag 1381921 caggcattca cctttttcat caaaagagaa gcaggaagaa ctttgaccct tatatcagga 1381981 ggctgagact tgagtaaaat ttatgtgtta gatacgaatg tgttattaca ggatcctaac 1382041 gcgatatttt cttttgaaga aaatgaggtt gtcatccctg ctgtcgtttt agaagaggtt 1382101 gattcaaaaa aacggtatat ggacgaagtt gggaggaatg caaggcacgt atctaagcta 1382161 atcgatgcgc taagacaaaa gggcaggctg catgagcatg taccgcttga caccggcggc 1382221 acactgagaa ttgaactgaa tcatcgttcg tttcaccagc tgcaagagat ctttattgaa 1382281 aagacgaacg ataatcgcat attagccgtt gcgaaaaact taagcctcga ggaagaaacc 1382341 aaggaaaatg gcaggccggt tatccttgtc agtaaggatg tactggtcag ggttaaagcc 1382401 gacgcaatcg gactgcttgc tgaagatttc ttgaatgacc gggttgtgga caatgatgaa 1382461 atgtacagcg gctataaaga tttatatatc agccagcagc tgttcagctc tttttacggg 1382521 aaaaatcaaa tttcagtaaa cgatgtgaaa cagcatgcgt tttatccgaa tcagtttgct 1382581 ttaatgaagg atgagctagg agggtcctcc tcggcagtcg gaattgcaga caaaaccgga 1382641 acggtattaa aaagactcgt atttgatgat gaacatatat ggggaatcag gccgaaaaat 1382701 gtacagcaga caatggcatt agagcttttg ctgcgggaag atattccgct tgtcaccctg 1382761 atcggcaaag cgggaaccgg caaaacgctc ttagctttgg cggcagggct attacagaca 1382821 gaagacttgg gaatatataa aaagctggtc gtcgcaaggc cgattgttcc tgttggcaag 1382881 gacatcgggt atttgccagg cgaaaaagag gaaaagctaa agccttggat gcagccgatt 1382941 tttgacaact tagagtttct gtttaatgcg aaaaaaccag gggagcttga tgctattttg 1383001 gcgggaattg gctcaattca ggtagaggcg ctgacttata tcagagggag aagcattcca 1383061 gatcaattta ttatcattga tgaagcgcaa aatttgacca ggcatgaggt gaaaacgttg 1383121 ctgacgagag tcggtgaggg cagtaaaatt gtcttaatgg gcgaccctga acaaattgat 1383181 cacccatatt tagacagtct gaacaatggt ttggcctatg tggttgagcg gtttaaagga 1383241 caacccatct caggcagcgt gaagctgtta aaaggtgaga gatcaggtct cgcccagctt 1383301 gcagctgatt tgctgtaaca cttaaatgat ttcgatctct tttacatcgg taatcggctg 1383361 tttgtgatga accgggtctt caaagtaaat atgcacgggg ccgccttctt gaatcggctt 1383421 gcctgcctca ctgaaatgga caatactgtt cagagcggtt tccagagaaa cggcggcctt 1383481 tcccgaactt gtgacaaata cacattgtgt cgcagagctg ttcggctcag catttttcag 1383541 gacagtccca agtctcattg cgaaactgcc gttcatcagt ttttgcttct catattgctt 1383601 ttccgtcttt aatgtaggcg gcgcgattcg cccctctctg atgacgcgtt ccggatcaag 1383661 gtcggattca tccccggctg attgtaaata tgtgtcttga ctgtcccctt tgcggtcaaa 1383721 cgaaaatttg cgatcatcaa aaatccatac gcttggatca atggtaattg gatatgtaac 1383781 attgcctttt acttggataa cgctcatgat atgaccccct tctctcaaaa ttataaaagt 1383841 tttcgcatga attgtcactt tgtgtacaaa ttatgtgtat tgaaatgctg agggaacgag 1383901 ggtgtttgca tggtatgcca gcataatgat gagcttgaag ccttagtgaa aaaggcgaaa 1383961 aaagtaacgg acaaggggga ggtagccagc tatattcccg ccttggcaaa agctgataaa 1384021 cacgacctgt cagtggcgat ttattattcc aataatgttt gtctgtcagc aggtgacgta 1384081 gaaaaaacat ttacgcttca aagtatatcg aaagtccttt cccttgcttt ggtgttaatg 1384141 gaatacggca aagataaggt cttcagttat gttggacagg agccgaccgg tgatccgttt 1384201 aattcaatta tcaagctcga aacagtgaat ccgagcaagc cgttaaaccc tatgattaat 1384261 gccggggcat tggtagtgac aagtctgata aggggaagaa cggtaaaaga gagacttgat 1384321 tatttgcttt cttttatcag aaggctgaca aacaaccaag agattacata ctgccgggaa 1384381 gtggctgaat ctgaatacag cacttcaatg attaatcggg cgatgtgtta ttatatgaag 1384441 cagtacggca tttttgaaga tgatgtagag gcagtaatgg atttatatac gaagcaatgc 1384501 gcgattgaga tgaacagctt ggatttagcg aaaatcggat ctgtattcgc attgaacggc 1384561 agacatccag agactgggga gcaggtcatc tcaaaagatg tcgctagaat ttgcaaaacg 1384621 tttatggtga cgtgcggaat gtacaatgca agcggggaat tcgcaattaa ggtcggaatt 1384681 cctgcgaaaa gcggcgtatc cggcgggata atgggcattt cgccttacga tttcgggatc 1384741 ggcatattcg gccccgcatt agacgaaaaa gggaacagca ttgcaggtgt aaagcttttg 1384801 gaaataatgt ctgagatgta caggctgagt attttttaat ttatgtcata tgcttaaatc 1384861 ctcttgcatt ttctgttgat accctttatg ataaatagaa gaattaggta ctcgcctggg 1384921 gaacggaggg atacttttgg cttcagagat gatagttgac catcggcaaa aagcttttga 1384981 actcttaaaa gtggacgctg agaagatttt gaagctgatc cgagtacaaa tggataactt 1385041 aacgatgcct caatgtcctc tatatgaaga ggttttagat actcaaatgt tcgggctttc 1385101 gagggaaatc gattttgctg tccgcctggg attggttgat gaaaaagacg gtaaagacct 1385161 tttatacaca ttggagcgcg aattgtctgc tttgcatgac gcgtttacag ctaaataaat 1385221 gataaaactc aaacttatta acagtttggg tttttttata accgctattt ttctctcatc 1385281 tcataaaaga cggtcttttt ttacacattc cttccgaatc gtatagagat tcttcgtctc 1385341 gtttgataaa ttgtagtaaa ataaaaaaga taaatacata aaaaccatag ataatggaag 1385401 ttagaagcag ggaagaggat gttatgttaa aaaaaatgct aaaatcttat gattactcac 1385461 tgatattcgc aatcgtttta ttatgcggat tcggtttagt gatggtatac agctcaagca 1385521 tgattacggc tgtctcccgg tatggagtaa gcagtaattt tttcttcatg cggcagctgt 1385581 ttgctttaat tgcgggtggc gctctattta ttctcatggc gttgtttcct tataaagcac 1385641 tggcccatca aaagtttcag aaggggatac tgcttgtatc tgttcttgcg cttatctcac 1385701 tgtttgtttt cgggcatgtt gccggaaacg cgcagagctg gtttaaaatc ggcggaatga 1385761 gtattcagcc gggggagttt gtgaaactgg tcgtgatttt ataccttgca gccgtatatg 1385821 caaaaaaaca aagttatatc gaccatctgt taacgggagt agcccctccg gtagtcatga 1385881 cgcttataat ttgtgggtta attgccatgc agccagattt cggtacagcc atgattatag 1385941 ggttaattgc gacgtgcatg atcttgtgct ccggcttcag cggaaagacg ctggtgaggc 1386001 ttgtgatact gggcggaatt gttttcattt tagtcagccc tattatctat ttgaatcagg 1386061 acaaaatttt aactgaaggc cgtttagcgc gttttgagag tcttgaagac ccatttaagt 1386121 atgcaaattc atcaggtttg caagtgatca attcttatta tgcgatcagc tcaggcggca 1386181 ttttcggcct ggggctcggt gaaagtatcc aaaaatacgg atatctgcct gaatcacaca 1386241 ctgactttat tatggctgtc attgctgaag agctcggcat ttttggggta ttgtttgtga 1386301 ttttcttatt gggttttgtc gtcataaaag gtttttatat tgccagaaaa tgcgaggacc 1386361 cgtttggaag tcttctggcg atcggcattt caagcatgat tgccatccag tcgtttatta 1386421 accttggcgg tgtcagcgga ttaattccga ttacaggggt tacgctgcca tttatcagtt 1386481 acgggggctc ttctttggtg ctgctgctgg ggagtatggg gatattagcg aatatcagca 1386541 tgtttgtgaa atattcagag aataagaaaa agaaagagcc cttggcgccg aagggaatga 1386601 aaaagaaaca gctcaaaaaa actgtttatc tgtaaaaaac aagtgtgtac aggggaagga 1386661 tattccgcta tgatagatta tattccattc gggtaagggg gagaaaagtt tgtctcagca 1386721 atcgatacaa aaagtattag tagcaaacag gggagaaatt gcaatccgaa tattccgggc 1386781 gtgtaccgag ttgaatattc gtacagttgc ggtctattca aaagaagatt ccggttccta 1386841 ccatcggtac aaagcggatg aagcatactt ggtcggtgaa gggaaaaaac cgattgatgc 1386901 ttacctggat attgaaggta tcattgatat tgcgaaaaga aacaaagtcg atgcaattca 1386961 tccgggatac ggtttcttat ctgaaaatat tcattttgcg agacgatgtg aagaagaagg 1387021 catcgtattc atagggccaa aatccgagca tctcgatatg tttggtgaca aggtaaaagc 1387081 gcgtgagcag gcagaaaaag cgggaatccc cgtgattccg ggaagcgacg gtcctgccga 1387141 aacgcttgaa gccgtcgaac aatttggaca agctaacggt tatccgatca tcattaaagc 1387201 ctcgcttggc ggcggcggcc gcggtatgcg gattgtcaga tctgaaagtg aagttaaaga 1387261 agcatatgag cgtgctaaat cagaggcgaa agcagccttt ggcaatgatg aagtttatgt 1387321 agaaaaatta attgagaatc cgaaacatat tgaggttcag gtcattggag acaagcaggg 1387381 caatgtcgtc catctttttg agagggattg ctccgttcaa agacgccatc aaaaagtcat 1387441 tgaagtggcg ccgagtgtct cgctgtcacc tgaattaagg gaccaaattt gtgaggctgc 1387501 agttgcgctt gccaaaaatg taaactatat aaatgcgggg acggtcgaat tccttgttgc 1387561 aaacaacgag ttctacttta ttgaagtaaa tcctcgcgta caagttgaac acacgataac 1387621 agaaatgatt actggtgtcg atattgttca aactcagatc cttgttgccc aagggcacag 1387681 ccttcacagc aaaaaagtaa atattcctga gcaaaaggac atttttacaa tcggctatgc 1387741 cattcagtca cgggttacga ctgaggatcc gcaaaatgat ttcatgcctg atacaggaaa 1387801 aatcatggct taccgctcag gcggcggttt tggtgtccgt cttgataccg gaaacagctt 1387861 ccagggcgcc gtgatcacac catactatga ttcacttctc gttaagcttt caacttgggc 1387921 tttaacgttt gaacaggcag ctgccaaaat ggtgcgaaac cttcaggagt ttagaatcag 1387981 aggcataaaa acgaacattc cgttccttga gaacgttgca aagcatgaga agttcctgac 1388041 agggcaatat gatacatctt tcattgatac aacgcctgaa ttatttaatt tccctaaaca 1388101 aaaagaccgc ggaacgaaaa tgctcactta catcggcaat gtgacagtga acggcttccc 1388161 tggaatcggg aaaaaagaaa aaccggcgtt tgacaaaccg ttaggcgtaa aggtagacgt 1388221 tgatcagcag cctgccagag gaacaaagca aattctcgat gaaaaaggtg cagaagggct 1388281 tgcaaattgg gttaaggagc agaaatctgt ccttttaact gatacgacat tcagggatgc 1388341 ccaccaatcg ttattggcaa ctagaatcag atcgcatgat ttgaaaaaaa tcgcaaatcc 1388401 gacggctgcg ttatggcctg aactattcag tatggaaatg tggggaggcg cgaccttcga 1388461 tgtagcctac cgattcctga aagaagatcc gtggaaacgt ttggaagatc ttcgcaaaga 1388521 agtgccgaat accttattcc agatgttgct tcgctcatca aatgcggtcg gctatacgaa 1388581 ttatccggac aatgtgatta aagaatttgt gaagcaatca gctcaatccg gtattgatgt 1388641 gtttcgtatt ttcgacagct taaactgggt aaaagggatg acgttagcca ttgatgctgt 1388701 tagggatacc ggcaaagtgg cagaagctgc gatttgttat acgggagata tccttgacaa 1388761 gaaccggacg aagtacgacc ttgcatatta tacatcgatg gcgaaggagc ttgaggcggc 1388821 cggagcccat attctcggga ttaaagatat ggcagggctg ttaaaaccgc aggctgcata 1388881 tgagctcgtt tctgcgttga aagaaacgat cgacattccg gttcaccttc atacgcatga 1388941 tacgagcgga aacggtattt atatgtatgc gaaagctgtt gaagccggcg ttgatatcat 1389001 agacgtggcg gtcagctcaa tggcgggatt aacgtcacag cctagcgcga gcggatttta 1389061 tcatgcgatg gaaggcaacg accgccgtcc ggaaatgaat gtccaaggcg ttgaattgct 1389121 gtcccaatat tgggagtcgg tgcgtaaata ttatagtgaa tttgaaagcg gaatgaagtc 1389181 tccgcatact gaaatttatg aacacgaaat gccagggggc caatacagca acctgcagca 1389241 gcaagccaag ggagtaggcc ttggcgaccg ctggaacgaa gtcaaggaaa tgtacagacg 1389301 cgtgaacgat atgttcggtg acatcgtcaa ggtaacgcct tcctcaaaag tagtcggaga 1389361 tatggcactc tacatggtgc aaaacaatct gactgaaaaa gacgtttacg aaaaaggtga 1389421 atctttagat ttccctgatt ctgtcgtgga gctttttaaa ggaaatatcg gccagcctca 1389481 tggcggattc ccagaaaaac tgcaaaagct gatcttaaaa gggcaggagc cgattacagt 1389541 cagaccgggc gaactgcttg agccggtgtc atttgaagcg atcaaacagg aatttaaaga 1389601 gcagcataac ttggaaattt cagatcagga tgctgtggca tatgcccttt atcctaaagt 1389661 cttcactgat tatgtgaaaa cgacagaaag ctatggagac atctcggtat tagatacacc 1389721 gacattcttc tacggtatga cattaggtga agagatagaa gttgaaattg agcgcggcaa 1389781 aacgctgatc gttaagctga tttcaatcgg tgagcctcag cctgatgcca cccgcgtcgt 1389841 ttatttcgaa ctcaacgggc agccgcgtga agtagtcatt aaagatgaaa gcattaagtc 1389901 ttccgttcag gaaaggctga aagcagaccg gacaaatcca agccacatcg cagcttccat 1389961 gcctggaaca gttattaagg tattggctga agcaggcaca aaagtcaata aaggtgatca 1390021 tttgatgatt aatgaagcga tgaaaatgga aacaacggtt caggcgcctt tctcaggaac 1390081 aatcaagcag gttcatgtga aaaatggtga gccgatccaa acgggagatc tgctccttga 1390141 aattgaaaaa gcataaaaaa caaagagtgt atatcaatga tatacactct tgttttttat 1390201 atagaaaatg tggagtgaaa cagatggtta gaagagatat aaggggactt cagagattat 1390261 agagtactgt cacaagccca aaataaaaag aggcttatac agccaatatt ttagatgctt 1390321 tgtagtatgc cgtgcatatt tctttaagca ctatctgatt taaaaggctt taatacttat 1390381 gttcgcgagc tatagatcca tatgaaattt ctataatcac gatgagaaag gggacagacc 1390441 gaagtgagcc gctcactgat catcaagttc ggcgaaggct ggcgattgaa acgcataaag 1390501 cgccaaaaaa caagacataa aaaagaccaa agccgcctaa ggctttggtc ttgagtcctt 1390561 atgattgcct ggattcataa cggaaacgag caatcaataa taagaagtag catagaacgc 1390621 caaacagaca ggcaataaag aacgagtggg caagtgcaaa gcccagagcc agttcagagt 1390681 atacgatcat aataccggac agtgcctgta atgtaatgaa aataagacat gagatccatc 1390741 cccaaaagat ctgtttttga tctttatagg aagtaatagc atgaacagcg gcaacaataa 1390801 tccatacaaa taaaagtaag gctgctgctc tgtggcccat ttgcacccat tcatggaatt 1390861 gggtcggaag tccattgttc agcgggctgc acagcggcac attaggacat gccagacttg 1390921 attcagtgtg tcttacatat gcgcctgtat acacaacgat ataggaatat attaaaattc 1390981 ctatcatgtg aaattgcatc tttttgccga tttgaagcgg cttaaccagt gttctgactg 1391041 atttatcagc ttcaaatatg agcaatgtta aaataagcac tgaagcaaaa gaaattaatg 1391101 agatgccgaa gtgaagcgcc ataatcagcg cgttcgaacc gaatacgaca gccaatgcgc 1391161 caagcaatgc ctgaagaaat aaaaagataa ttgacatgat cgcgagaaac gttgtttcac 1391221 gaaaaatcgg cgtgattttt ctccatgacc aaaacgcaag gcttagcaca aggataatag 1391281 agattccgct tgcgaatcgg tggctccatt caataattga agccggattc agttcaggga 1391341 aaaaacggcc gtgacacagc ggccactgtc tgccgcatcc ttggccggaa cctgtttttg 1391401 taacgagggc acccccgatt aaaacaatta gcatgacaaa tgtcgtcaga acaccgagag 1391461 cttttaatgc tttattcata caatattcac cttcttaaca tactgctgca attttatata 1391521 cgttccaagt gtaagcgaat atgtgttttg tggcaattcc cagagccttt tgttcacaaa 1391581 aatataatag aatgacggct tctggaaaat gtacacttga ttattcatgc cgggtctgat 1391641 agaaataagg taaacgcaat gccgatttgg agattgcctt catctttggt aaaattcata 1391701 aaaagttcac aaataaattc ctgtttgtcg tttaatattt aataggatgt ttttttacaa 1391761 gatgttatct tgtatgatag agttgcaggt tattttattc tcctgcgtta ggtttgtaag 1391821 ggaggtttac gttatggcta actccagaat cttaaatgat acagctatag acggacaaat 1391881 tgaagaaaca acggcatgga aagattttct gtcccttatt aaaataggga tcgtcaattc 1391941 taacctcatc acgactttca ctggaatgtg gcttgcactg catatatccg gtttaagttt 1392001 tttaggcaat ataaacaccg ttcttcttac gttaatcggg tcttcactga ttattgcggg 1392061 ctcctgcgcg atcaataact ggtatgaccg ggacattgac catcttatgg agcgtacgaa 1392121 agtaagaccg acggttacgg gtaaaattca gccgagtcag gcgttatggt ctggaatttt 1392181 gctggttgct ttaggattga tcatgctgct gatgacaact gtcatggctg ctgttatcgg 1392241 ttttatcgga gtctttacgt atgttgtatt gtacacaatg tggacgaaac gccgctatac 1392301 gattaacaca gtagtaggaa gcgtttccgg tgcagtgccg ccgcttattg gatggacggc 1392361 agtggaaggg aatatcggtg tcgtagcatg ggtgttattc atgattttat ttatttggca 1392421 gattcctcac ttcttagcat tggctattaa gaaaactgag gattacagag ctgcaaatat 1392481 tccgatgctt cctgtcgtat acggatttga agtgacaaaa agacaaatta ttgtgtgggt 1392541 tgcgtgcctg atgccgcttc cgtttttcct tggtagcctg ggtcttccga ttgtcattct 1392601 cggcttgctg ttaaatatcg gctggctgat tcttggctta atgggattcc gctccaagaa 1392661 tatcatgaag tgggcaacgc agatgttcgt ttactcgctt aactacatga caatctattt 1392721 cgttgccatg gttgtcttga cgcttttcta aaaaatagat atgatgcttg ttttatcgct 1392781 tcaaaataaa cgatgacaac tagtaaatgc cgccttgacc tcttgtttaa tcaggcggct 1392841 ttacttttat acatagatgg cattttgagt aaaaaaactc ataatttaag agaagaggaa 1392901 atgtaagtgc tttattggtg ataggttgga tggcgataga tttcgatccg ctttccgcct 1392961 ttgtattgac cagaaaaggg gttgggtgaa atggtaaagc attggcgtct tattttatta 1393021 ttagccttag tgccgcttct attaagcgga tgtggaaaac cttttttatc cacgctcaag 1393081 cctgctggcg aggtggctga taaacagtat gacctgacag tgctcagcac attgattatg 1393141 gtggttgttg ttgcagtagt atctgttatc ttcttttatg tgattgtgag attcagaaga 1393201 tcacgggtcg gtgagaacac gataccgaaa caggtagagg ggaataaatt tttagaaatc 1393261 acatggaccg tgatcccgat tttgctgctc attattcttg tgattcctgt tgtattatat 1393321 acgctggagc tagcggacac atcaccaatg gataaaaaag gccgcaaagc tgaggatgct 1393381 cttgtagtca atgttagggc aaatttatac tggtgggagt ttgagtaccc tgattacggc 1393441 attatcacaa gccaggagct gattgtaccg acagatcagc gtgtatattt taatttaaaa 1393501 gcctctgatg taaaacattc cttctggatt ccttcagttg gaggaaaact tgatacgaat 1393561 acggataatg aaaataagtt cttcctgaca tttgattcaa aacgaagcaa agaggcagga 1393621 gatatgtttt ttgggaagtg tgcagagctt tgcggccctt cacatgcgct gatggatttt 1393681 aaggtgaaga cgatgtctgc aaaagaattt cagggctgga caaaagaaat gaagaactat 1393741 aagtctacag cagagagcga tttggctaag cagggtgaag aactgtttaa agagaaaaac 1393801 tgcctgagct gccatgcggt agagccgaat gataagcgtg cagaagccgc tagaacggca 1393861 cctaacttgg cgaccttcgg tgaaaggaca aaagtggcag gggtgaaaga ggccaacaaa 1393921 gaaaatgtga aggcttggct gaaggaccct gacagcataa agccggggaa caaaatgaca 1393981 ggcacatatc caaagctctc agacagcgaa acaaatgcgc tttatgaata cttaaaaggc 1394041 ttaaaagcgg aaagcaagta gggaagaaag ggagatattg ggggaggtca catatgttga 1394101 atgcgcttac agaaaagcgg acgcgcggat ctatgctttg ggattatttg acgacggtgg 1394161 accataaaaa aatcgcaatt ctttatttag tggcaggggg attcttcttt cttgtcgggg 1394221 gaattgaagc gatgtttatc agaattcagc ttgcaaagcc ggaaaatgcg tttctcagtg 1394281 ctcaagcgta caatgaagta atgactatgc acggaacgac gatgatcttt ctggctgcga 1394341 tgccgctctt atttgccttg atgaatgcgg ttgtgccttt gcagatcggg gctcgggacg 1394401 tttcgtttcc atttttaaac gcgcttggtt tttggctctt ctttttcggg ggcattttct 1394461 taaatctaag ctggtttttg ggcggagcgc cagatgcggg ctggacatca tatgcctcac 1394521 tttcgcttca ttctaaaggg cacggcatag actttttcgt cctcggactc caaatatcgg 1394581 ggctcgggac gctgatagcc gggattaact ttttggccac gattatcaac atgagggctc 1394641 cgggcatgac gtatatgagg ctgcctttgt ttacatggac gacatttgtg gcctcggcat 1394701 tgattttgtt cgcgtttccg ccgcttacgg ttggattggc tctcatgatg ctggatcggc 1394761 tgttcggaac caatttcttt aatccggagc ttggcggaaa tacggtcatt tgggaacatt 1394821 tattttggat cttcggccac ccggaggttt atatcctaat tttgcctgca ttcggtattt 1394881 tttctgaggt catccctgtg ttcgccagaa agcgtttgtt tggctattct tcaatggttt 1394941 ttgcaatcgt gctcattggc tttctgggct ttatggtttg ggtgcaccac atgttcacga 1395001 ctggtctcgg cccgattgca aatgcgattt ttgcggttgc aacaatggct atcgcgattc 1395061 cgaccgggat taagattttt aactggctgt tgacgatttg gggaggaaat gtgaagtata 1395121 caaccgctat gctgtatgct gtctcattta ttccatcctt tgtgctcggc ggtgtgacgg 1395181 gagtcatgct ggcagctgct gcggctgatt atcagtttca tgatacgtat tttgtggttg 1395241 cgcacttcca ctacgtcatt attggcggcg ttgtattcgg ccttttagcc ggtgttcatt 1395301 tctggtggcc gaaaatgttc ggtaaaattc tgcatgaaac gatggggaaa atttcatttg 1395361 tattgttttt tatcggcttt cacctcacgt ttttcattca gcattttgtc ggcttaatgg 1395421 ggatgccgcg ccgggtttat acgtttttgc caggacaggg tctggaaacc ggcaacttga 1395481 tcagtacaat cggggcgttt tttatggcgg cagctgttat tcttctgctg gtcaatgtca 1395541 tatggacatc ggtaaaaggt gaatatgtag gtgctgatcc atggcatgac ggacgtacgc 1395601 tggaatggac cgtttcttca ccgccgccgg agtataactt taaacagctt ccttttgtca 1395661 gaggacttga tccgctttgg atcgagaagc aggcagggca caaatcaatg acgccggcgg 1395721 aaccggttga tgatattcat atgccaaacg gctcaatcct gccgctcatc atttccttcg 1395781 gcctttttgt cgcagcgttc gggctgctgt acagaagtga ttacgcttgg ggcctgccgg 1395841 tgatctttat cgggctcggc atcacattta ttacgatgct gcttcgttca gtaattgatg 1395901 atcacggcta tcatattcat aaagaggaac tgccgaacga tgataaaggg gtgaaggcat 1395961 aatgcaagtt caagaaaaat tcaccgcaga aacctttcca gcttctcctg aaaaagtaac 1396021 cctggaaggg aaaaataaat ttttaggctt ttggcttttt cttggcggag agactgttct 1396081 gtttgcgtct ctcttcgcca cgtttcttgc gcttcggaat tcaaatgccg gtgatccgcc 1396141 tacgacggaa atgttcgatg tgacacttgt attcattgcc acaatgcttc tattaacgag 1396201 cagtttaacg agtgtgtacg cgatgtacca catgaagaac ttttccttcg gcaagatgca 1396261 gctttggctg ggaattacga ttttattggg ggcgggcttt ttaggactgg aaatctatga 1396321 gttcaagcat tacacccatg aatttggctt taccatcaca agctctgccc ttggttctgc 1396381 gttttacacg cttgtcggta cacacggcgc ccacgtggca tttgggctta tgtggatcag 1396441 cacgcttatg atccgcaatg ccaagagagg gctgaatctg tatacggcgc ctaagtttta 1396501 cgttgccagc ctttattggc actttattga tgtcgtgtgg gtcttcatct ttaccgttgt 1396561 atatttaatg gggatggtgg gataaacatg gtcgataaaa aaagcagagg gcatatcaat 1396621 agcgaccttg aatttaagaa aaaaaagcat gcccgggaga tgaaatatca agtcctgtct 1396681 tttggtttaa tgatcggtct tacgattgtt gcatttctga ctgtggccac ggacggtgtc 1396741 ggcagctggt ttacgattcc tttcattatt ttgctagctg caattcaagt catttttcag 1396801 ctgtattatt tcatgcatat gaatcagaaa gggcatgagg cgccggcact gtttttgtat 1396861 tcaggggtgt ttgtcgcgtt tatcactgtg cttgcgtttg tgacaattat atggtggtaa 1396921 tttgaacagc cgccggaggt gaagaaatga atcagttgga gatatttggg tttcgcgcga 1396981 tgtggagccc ttatcttttt tgtatcctgt taggcattac ggcgctttat ctctattttt 1397041 acaggcgaat gtcttcaaag ccgaatcgaa taactggtaa agagatggtg tgctttctgt 1397101 cggcgatgct gtttttatat gcagccgagg gaagcccggt tgatctgctc ggacatatta 1397161 tgttcagtgc gcatatggtg cagatggccg tcctgtattt ggttgtcccg ccgctgttaa 1397221 tcgcggggat tcctgcatgg ctctgggaaa aaatcatttt caggccttca atcaaaccgg 1397281 ttttttcctt ttttacgacg cctttaattg ctttgctttt gtttaacggc attttttctt 1397341 tatatcatgt accgcttata tttgatactg tcaaaacaga tccgttttac catacattaa 1397401 tcacttggct tatctttgtg cttgcgttct tcatgtggtg gccgcttgtt cataaggttg 1397461 agcgtctacg gcagctcagc ggcttgatga agctgggtta tattatggcg gacggtatgc 1397521 tgctcacacc tgcttgcgcc ttgatcatgt tcagcggtgc accgttatac gccacctata 1397581 cagatccggc tttatgggct gaggcaatga ggctttgcgt gccagcggat atgatggggc 1397641 aggtcccatt aacagggcca gagatgttga atacactgcc tttgttagag gatcagcagc 1397701 tcggagcagt catgatgaaa atcattcagg aaattgtgta cggtactttt ttggccgtta 1397761 tttttttcca atgggtgaag aaagaaaggg aaaaggacgg gcaggaggag ccgccgtata 1397821 ttcagcagac gatatcataa aaggtacagc gaaatatgct gtaccttttc gttacatttg 1397881 aactgttttt aacatgttgg ctatgtcctg aatcagtgcc ttgctttttg tcacaacctg 1397941 tacgggaaac tcttccgttt ctccatattc tactccatga gggtagtaat gctttcctag 1398001 gagaggggac attaattgaa tcacggcgcg cccgcttccg acatcgcctt ctgccgcaat 1398061 accttgtatc cgcaggtaaa acgtaccctc aatcgtcgaa aacttcttgt cataggtgac 1398121 tctctcgtaa tcccattgac ccgctctgat aagacctttg ctttccatta agtcgtctag 1398181 ccagctgagc tcagccttaa ccccttcaag tccgctttca gtaaacttca acactgaccc 1398241 ctccttataa aaattacctt tcctgacaat catagtatga aagcgttaaa ctttcaatga 1398301 atcttcttct tttgaaagta tgcaaaaatt aaattttgac gacaatagca ctagactaaa 1398361 ggaggttaaa cggatgacaa aaataaaaga tctgatgaca gccgacttgc aatattgcac 1398421 ggtattagat aatgtatatg aagctgcagt aaagatgaag gacgcaaatg taggagcgat 1398481 accggtagtt gatgaggacg gggaaacatt ggtcggcatc gtaaccgacc gcgatctcgt 1398541 attaagagga atcgccatca aaaaaccgaa ctcgcaaaaa atcactgacg cgatgactga 1398601 aaaacctgtc agtgtggagg aagatgcttc agtcgatgag gttcttcatt tgatggcatc 1398661 gcatcagctc agaaggatac cagttacaaa aaataaaaaa ctgactggaa ttgtcacgct 1398721 tggtgatctt tctttatctg agcaaacgaa tgaacgtgcc ggcagcgcct tatcggatat 1398781 ttccgaaggg gataatagag aagaaggctt ttttcattaa cacataaatc tttgacatgt 1398841 taaataggct gtattgtaat gggatgtaaa caagagattg tgaatcgcca cgggggtgat 1398901 agattgaaaa atatattgag agcaatggtt atccttttga ttatctgcgg aacctatgtt 1398961 ctgtttattc aatatggatc tgttcctgaa aagaaatcaa atgacagcga gcctcaggtg 1399021 tcgaatgagg aagcgcaaag cggcaaacga atacatatgc cgacttcagg gttattgtcc 1399081 ttcatgggca agcacgccga tgaagtaacg aaaaagcttg gggaacctga acgtattgac 1399141 ccttcggctt atgattacga ttggtgggta tacaatcaag gtaaggatca atatatccaa 1399201 atcggggtat taaacaataa agtggtcaca ttattcgcgt cgggtaatga tattaacgcc 1399261 aagcctttca aaattggaga atcaactggc gaagtattca agaccaccca ggtggcacca 1399321 tttgtgaatg tagagtataa aggaaattcc tatcggtttg aattttctga agaagatatc 1399381 aatacaagac cgactgtaaa ggtaggaaag atgtatgtcc agctgtatat ggacaaattt 1399441 gaggggaagc tatccagcat cagggcgttt gatgcgcaga cctttgtaaa gcaaagacct 1399501 tatgaggtag tgtaccgcgg ggaattaatt aaaccgaaag ccgtttcaga tgagaaatgg 1399561 aaaaagatcc aaacaacgag cgaaaagcaa atccttgatt tgacgaatgt catacgcgtt 1399621 aaacatggac ttgcgaagct tgagtgggat cagccaacgg cggaagtggc atttgggcat 1399681 agtgaggata tgaaggaaaa taattatttc tcccatgtct ctaaaaaata cggctcgctg 1399741 aaagaccgct tagaagaagg gcatgttgat tttcagcaag cgggagaaaa tatcgcatac 1399801 aattatgtgg acggtccggc tgctgtagaa ggctggctga atagcgaagg ccatcgaaaa 1399861 gcgcttctga attcagatta tacgcatctt ggtgtcggag tagaccggaa atattacacc 1399921 caaaacttta ttaagcgatg gtaatgaaag ccgcggacga atggttcccg gctttttcta 1399981 tttccataca agctggtctg aatgaatgtg ctgatagctt acagataagg ccgtttccca 1400041 tcccttcagt caggcttttt caccagtgta tagggatatc gctaaaaatt catttgggaa 1400101 tgaatatagg cgaacacaat gcccgacaaa acgatacatt gtagtaggta acgattttcg 1400161 gagggggtga ggattgtggc gaatcaacat gccaatcatt caatcaatga ctttaaacaa 1400221 ttcgtcaaaa agcatcccaa gctgataaaa gaagtgcgca aagaacaaag aagctggcag 1400281 gacgtatatg aaaattgggt cctcttcggg gagagcgacc cgatttggga tccatatcgg 1400341 gaaccggaag aagcttctga agctgtgcct gaaacaccgc aaaaaaatga ttttgtctcg 1400401 aaaatggtga cagcggtgaa aaagatggat gtcaatcaaa tgaacgaaca aatcaataaa 1400461 atgagccagt cgatctcatc gttgcaaagc cttcttaata cattttccgg aagcggacag 1400521 aagcattctc agccaggctc tggacagcat cctttttctt ttcgaaagga ttaaaaaagg 1400581 ggagctcata tgcgcaaaga ggttcaggaa tatattttag caaacgaaga acggaaacga 1400641 ttcatcagag aacagccgat atggtaccgc aggctttcaa gaaaaccgga tgatctgtcc 1400701 tcctttcagc ttgaaatgat gaatttttat gaaaaaacca ttccgcatcg ggtgaatcag 1400761 tttacgaacg ggattcaaat ggcgcaaatg atgatgcaaa tgtttcaagc gatgcggaca 1400821 aaagattaaa aggccccgaa gaagggtctt ttttcatgcg gtcataaggt tttgttggcg 1400881 gctgcggtta agcattttcc aattggctgg tttcatggta aactaacaac tggaggtgca 1400941 tgttatgtat gcgacgatgg aatccgtgcg gcttcaaagt gaagctcagc agcttgccga 1401001 gatgattctg cagtcggaga cggctgagaa ctaccgcaat tgttacaagc gtctccagga 1401061 agatgaagag gcaggtcgga ttattcgttc ttttatcaaa ataaaagagc agtatgagga 1401121 tgtacagcgt tttggcaaat atcatcctga ctatagagaa atatcccgga aaatgaggga 1401181 gatcaaacgt gagctggacc tgaacgataa ggtggctgac ttcaagagag ctgaaaatga 1401241 gctccagtcc attcttgatg aggtcagcgt tgagattggg acagctgttt cggagcatgt 1401301 gaaagttccg actgggaacc cttattttga cggtttgtct tcatgcggag gcggctgcgg 1401361 ttcaggcgga agctgcggat gtaaagtgtc ctgacgagac tggccgtctc gtcttttaca 1401421 tataagagaa aacaggcagg tgattgtatt ggagaatagg cgccagggca tggttgtgta 1401481 tctgcactcc ctaaagcaga gcaaaatgct gaggaagttc gggaatgtgc actatgtatc 1401541 aaaacgatta aaatatgtcg tactgtactg tgatatggac caaattgaaa aaacaatgga 1401601 caagattgcg tcttactcat ttgtgaaaaa agtggagcct tcttataaac cgtttttaaa 1401661 attggaattc gagtcaaagc ttgataaggc aaaagaatac gattataaaa tcggcatata 1401721 gctataaaaa aatccccgca ggcatctgcg gggtccttct attccttaat atgttaagga 1401781 gaaggcaaag ggagaggaga aaccggagga agaacttatg gggaaacgta agtcttctcc 1401841 gcggttggca acaacatcct ctagatgctg ttgcttatag tatggacaag gatcatgctg 1401901 cctatacacc tgtttatcaa gattagcgtt cattgtttgg aagaatgctt tatgttaaga 1401961 taggattgat ttttttctat gtacatagcg gcgtccggcc gaataaagaa acaaaatagc 1402021 ttttagaaaa agtggtgtgg aacatgagag taatttctgg atcaaaaaaa ggccgttcac 1402081 taaaggctgt agccggaaca tcaacaagac cgacaaccga caaagtgaag gaatccattt 1402141 tcaatatgat cggcccttat tttgacgggg gcaggggact tgacttattc gcagggagcg 1402201 gaggtcttgg aatcgaagcg ctttcacgcg ggtttgagca ttgtatattc gttgaccgtg 1402261 attttaaagc gattcaaacg gtaaaatcta atttgaaaac gctggagctt acaaaacatg 1402321 cacaggtata ccgcaatgat gcggaacgtg ctttgcacgc tgctgctaaa agagaaaccg 1402381 gctttcgcgg aatttttctc gatccgccgt ataaggaaca aaagctgaaa gcacttttaa 1402441 ctttgattga cgaatatcaa atgctggaag aagacggctt tatcgtcgct gagcatgaca 1402501 gagaggtcga gcttcccgaa accgtaggag atcttgtgat gacaagaaaa gaaacctatg 1402561 ggttaacagg tgtagcgatt tataaaaaga gggggtagtg aggtggcgag tatagctgtc 1402621 tgtcccggca gttttgatcc tgtgacctac gggcatctgg acatcatcaa acgcggggcg 1402681 catatttttg aacaagtgta tgtatgtgtg ctgaataatt cttcaaaaaa gcctttgttc 1402741 agtgtggaag aacggtgtga gcttctgaga gaagtcacaa aagacattcc gaacataaca 1402801 gttgaaacat cgcaaggcct gttaattgat tatgcaaaaa gaaaaaatgc gaaagcgatt 1402861 ttaagaggct tgagagctgt atctgatttt gaatacgaga tgcaggggac atcagtaaac 1402921 cgggtgcttg atgaatctat tgagacgttt tttatgatga caaacaatca atattcgttt 1402981 ctaagttcaa gcatcgtaaa agaagtggca agatacaacg gctcggtatc agagtttgta 1403041 ccgccggaag tagagttggc gcttcagcaa aaattcagac aaggatgagg gttttgactc 1403101 atcctttttt tgttccgttt gtcagtctgt aagaaaaaat gataatgtac gtaaacagcg 1403161 cgcatagtgt gacagcaggt ccgatctgca caagcagatt ccagccgttt ataaaggcag 1403221 ttgacatgtc actgctgtta agagatttaa atacatactg atacggatca tgccatgctg 1403281 tgtaaagagg tttccataaa agcatgacga agacagcggc ataaacgccc tgcagcaaac 1403341 gtgcgataaa gaatggttta aatctaatgt cggtttccga taaaatacct gccacctgag 1403401 cttgtacgga aaagccgcta aacccaagaa taaagctgac gataatggct ttttgcagaa 1403461 gagaaacatc tgtctcgctg acaagcttgc tgcctaatgt aatttcaaac atccctgata 1403521 aaagcggaat gtccaattga gtcggaagct gaaacaaagt cagtgctcct tttgtgaaaa 1403581 cagacaaaac atcagtcagc tggaccactg acaacagccg attgaagaca gaaaataaaa 1403641 taataaagcc gcctaccata agaagcgttt gaacagaaga cgtcacggcg tcgcctaaaa 1403701 ttttacctaa gggccgtttt tctgcaagtc tggcggtatg aagagcgtgt aaagcatctt 1403761 tgactgaagg gaaaggtatc gttttctttc ttctgagatg ctgctcttcc ttgcggccat 1403821 aggagcgcat tgttaaaccg acggcaagat tccccaaata gtgtgcagaa gctaataaaa 1403881 tgcctagtga tgcgttttga aagaaaccga cggcaacagc gccgaaaata aagagcgggt 1403941 ttgaagaatt ggtaaacgac gcgagccgtt ctgcctctac tcttgaaatc tgattttcct 1404001 gccgcagacg ggcagtgagt tttgcgcccg ctgggtttcc tgatgccatt cccatagcaa 1404061 gaacgaagcc gccgacaccc ggcacgcgaa agatcggccg cataaaaggc tcaagcaaaa 1404121 caccgacaaa ccgcacaatg ccaaagccga ttaagagttc ggacagaata aaaaatggca 1404181 gcaatgacgg aaacacaacc tcccaccaca tagacagccc ggttttagag gcttcgaatg 1404241 aggcctgtgg atgtgagatg acagtcgctg ttaaaaaaag aaaaaacgag gcaatcaaaa 1404301 gtgtattaat cttcgacaag ttcattctta cctccccgat gctaaaaatg cccaatgaca 1404361 tgtatatcat gataaaataa tgtatgatgt aaaacggcca agcagtacct gtcctcttga 1404421 ttctttgtac taatatacga gcataggggt tcagtttaga ccatagaatt cggtatacag 1404481 ggaattcagg caggaggtta acgctttggc caaacctaaa atcgggttag cgttaggatc 1404541 gggaggggcc agagggcttg ctcatctcgg tgtgctttcc agtttacata agcaccaaat 1404601 tgaagtggat atgattgcag gaagcagcat gggcgctttg gtgggcagtt tttacgccgc 1404661 cggacatgac gtggcaacga tgaaaaaagt agccaaagcc tttaaacgaa ggctttatgc 1404721 tgattatacg gtgccgaaac tcggtttttt aaaaggtgac cgcgtcagac agcttgtgca 1404781 tgcttataca ttcggaaaac cgattgaaga gctccaaatc ccgctgggca ttgttgcgtg 1404841 tgatctacag acgggagaaa agattgtgtt ccgaaaagga tcagtgtcag atgcagtgag 1404901 ggccagcatc agcatcccgg gtatctttat tccgcagcgg ctggacggac gccttcttgt 1404961 agacggcgcg gtcgtcgatc gaattccggt ttctgttgtg aaagacatgg gagctgatat 1405021 tatcatcgct tcggatgttt ccagggttcg aaaaactgaa acagcagtgc atatttttga 1405081 tgtgattatg caaagtatgg atatactgca aaatgaatta gtgcggcatc aaacaattgc 1405141 cgcagatatc atgattcgcc cttcccttga aacatacagc tcaagctcgt ttgccaatat 1405201 tgaagaaatg atatcggcag gcgaagaggc gacaaaccga atgatcagca agataagaaa 1405261 agaaatagag aattgggagg gctcataatt tgctacgtaa aaaacatttt agctggatgc 1405321 tcgtcatcct catactgatc gccgttttat catttataaa acttccatac tatattacaa 1405381 aaccgggaga agcgacagag cttgcttcat tgataaaagt ggagggaggc tacccggaaa 1405441 aaggaagtct gtccttaatg actgttaaag tgggaccggc taatccattt acatatgtgt 1405501 gggcaaagat gcacccttat tatgaaattg ttcctgatga gagcattaag gaggaaggcg 1405561 aatcagataa ggagtatatg aaaagacagc tccaaatgat gaaaagctcg caagaaaatg 1405621 cggttatagc cgcctatcaa aaggcaggaa aaaaagtcag ctattccttt aacggcatat 1405681 acgcaagctc agttgtagaa aacatgccgg caaaagggaa aatagaagtc ggtgataaaa 1405741 tcatcagcgc agacggcaaa aactatcagt ctgctgaaaa gctgattgat tatatcagca 1405801 gcaaaaaagc gggagataaa gtcacgttaa agatcgaaag agaagaaaaa gaaaagcgtg 1405861 tcacccttac gttaaaacaa tttcctgatg agccggatcg ggcaggaatc ggagtttcgc 1405921 tttatacaga cagaaacgtg aaggtagagc ctgatattga ttttgaaatc gaaaatattg 1405981 gcggcccgtc agcagggtta atgatgtccc ttgaaatcta taatcagctg acaaaaccag 1406041 acgaaacaaa aggctacgat attgcgggaa caggtacgat tgatgttgac ggaaaagtag 1406101 gcccgatcgg cggcattgat caaaaagtcg tcgccgcaga caaagccgga aaagacattt 1406161 tcttcgcgcc aaatcaaaac ggcgccagca attccgatta taagaacgca gtaaaaacag 1406221 caaaagatat tgattcaaat atgaagattg tgcctgttga taccatgcag gatgcgattg 1406281 attatttgaa taagctgaaa gcgaaaagca cctgattctc aggtgctttt tctatacatt 1406341 taaaaagtgt tgttcatctt cgtcatatcg aatcggtgca tgtccgtatt cctgtaggtc 1406401 aaactcagtt ctcagcggct cttctatcgg caggctgtaa atcctgcttg cttttacgtc 1406461 cagatcgaga gctggatggg agaaagagga cagtttgctg acaagcggaa cagacagtgc 1406521 ttttttcttt tcggataaat aagcctgtcc ttttttcgtc atgccgagaa gcctgatata 1406581 cggcgcctta tcgttgtcaa gcagcttttg catatcctgt ttttttgttc tggttaaaat 1406641 gtgtgtattc atccgctgga gccttgtcca cgtatagcgt tttgttttca gcagttccat 1406701 aaattcctga taggagctgg attttctgat cgaacgaata attctgtgct ctaaaccttc 1406761 ctccacctcg tatacttgct gtaattcccg tgccgttaca gttgaaaggc tgtattttaa 1406821 gtaagaaaag tagctttcag gtgtatgcca caatccgaaa gatttgcggt aagctgctaa 1406881 ttcacgtgca gatgcagcag ggagaaaacg aaggcaggct tcgagattct ggccaatcat 1406941 cgcttttcta atgcttgtgg cacttgctat atggttttcg ccttcaggga gatcggcatc 1407001 atgatagtcc gaagagattc gtgccgtagt ataaggtttc ataggatatc ccccggttag 1407061 aatcgaggtc acatactggt atcccaaaat gttatttggt tttgacaagt caagtgcact 1407121 ttcagtatgc aaaatggagc tgaaggcgat agccgccgct gctgggtaac tggccccctt 1407181 tttaagttct tctttaattc ggtcattcaa tatatgttta tgctcatcaa taagctgtgc 1407241 tgtttctaaa aaaggcttga tatccccatt ttcactcccg aaaaacagcg cctcacattc 1407301 aagttcgttc aggatggaaa cactgccgcg tgcaaaaatg tctgcttttt gcacggcata 1407361 aagataaggc agctcaatga caagatcaac tccgctttgc agcgccattt ttgttcgggc 1407421 ccattttgat acaacagcgg gttccccgcg ctgtaaaaaa tgtccgctca tgaccgcgac 1407481 agccgtgtca catccggttt gcagctttgc tgtttgggca tgataaaggt gaccgttatg 1407541 aaagggatta tattcaacca ccaatccgac agctttcata ttttttccgc ctttcttgct 1407601 atgtttaaaa acgtatggta catttgcaaa tgaaaactct tacgccttat ttttgtttta 1407661 agtgtatgca tagcatattc cgctgtcaac gatacttcaa tggcagcatt atgctgtaaa 1407721 gaaaaaatat tgacaaaaac aatcttaaaa gctataatca tgtttgttgc tttcctgagg 1407781 tgatacaaat gaaatggacg atttatcagc tgcatcaaat gccaaaacaa agttttgagt 1407841 ttgatgaaac agttgagtta aatgagctga caaagctgaa ttctgacatt cgccgcattt 1407901 ctcccgttcg ggtgaagggc agagcggata tcaaatccaa acaggtttcg tttgatttta 1407961 caatttcagg cgaaatgctt ttgccatgct caagaacact cgttgatgtt ccgtatccat 1408021 ttgaaatttc aacaaaagaa ctgtttatat ttcatcacac ggatgatata gaagatgatg 1408081 acgttcacat tgttgaggac gatactatcg acataactcc gatcgtgaaa gaagaaattc 1408141 ttttagaaat ccctatgcaa atcttttgtg aatctgaaca agaaaaagga gctgctcctc 1408201 aagaaggaaa ggattggcaa gtcatttcgg aagaagacaa gaagaatcaa gttgatccga 1408261 gacttgcagc ccttgaaaag ctcttaaaac aagatgatga atcttaactc tttaaggagg 1408321 tgggaataat ggctgtacct tttagaagaa cttctaaaat gaagaaaaga ttgcgccgta 1408381 cacatttcaa acttaatgta cctggtatga cagaatgtcc gtcatgcgga gagatgaagt 1408441 tgtctcaccg tgtatgcaaa gcatgcggat catacaacgg caaagacata aatgtaaaaa 1408501 gtaactaatg agaaaagcgc agggtgaaag ccctgcgctt tttctttttc tcttcctgtc 1408561 agcttgcgga aaatttgtga gtgcaaatag tctatctaat ctattaccgg catatgtatg 1408621 agataaataa gctgacatgg agggagattg aatttgacca ttacaagaca agatgcttgg 1408681 actcaggatg aggatttgct gctggcagaa gtggtgcttc gtcatattcg agagggagga 1408741 acacagcttt cagcctttga ggaggttgga agggcgctga ccagaaccgc ggcagcctgt 1408801 ggtttcaggt ggaactcgta tgtgagaaaa caataccagt caggtataga gcttgcaaaa 1408861 aagcaaagga aagaactgag aaagcaaatc ggcgttcatt cggtcaatat gccgaattcc 1408921 atgaagcaga ctgcctcggc atcgtcagaa ggaaaacgag atttgtccat tcaggatgtc 1408981 attcaatttc tcgaacaatt caaagaaaca ccgtctgcac aagaatttca gcttgaaagg 1409041 gaaaaattga aggagcaaat ccaatcgctg caaaaagagc ttgaggattt gcggagtgaa 1409101 aatcagacat tgcggaatca gctagagatg acagaagagg attacaaggc actgatcgat 1409161 atcatggatc gggccagaaa aatggttgtt tcgaaggaag acggaagaat gaaaaaagcg 1409221 gctcaagaaa cgtaaagaaa cgcctgaaat gaaccggccc tatagtaaga ataggccggt 1409281 tgttttgatt tctatgcaga ctctcccggt gtcatttcgc gatccatatc aggatgccag 1409341 atgagcgggt tttccccttt gtcccgcgcc atatcatact taacagtttt aaagttcatt 1409401 ttgttccaaa attccgctga tttcattctc ggatttgtcc ggatcggcat tttgaatgat 1409461 tttgcaaatt caaccaaggc tctcccgtat cccctgttct ggtagcccgg aagaacctca 1409521 agcttccaca gctccaaata atcctggcgg ttgtcaaaat agggattcga tttgccgtta 1409581 acttgataca gactcattcg tgctacaagt ttatcgccaa aataaatccc gtaaaaaggc 1409641 gaggtgctgt cattttcaat aatattatcc tgaagttctt caagcattga aagctcctga 1409701 atgccgtatt ctttgaattt cttgaattct tccagcgttt tatagttgat aagcagacgt 1409761 tctacctttg tcaaacaaat ctcccccttt gttgtttcta catatattgt aaacgcttta 1409821 tttaaaaaat ccaaatattt aaactttaat tttaagcaca tgggatcttt gagaagtaat 1409881 ttcttcttac ttctgctatg ataatacgta aatgctaaat tgggtgtgac atcatgaaaa 1409941 ttggaattat cggcggaggc tccgttggtc ttttatgcgc ctattatttg tcactttatc 1410001 acgacgtgac tgttgtgacg aggcggcaag aacaggctgc ggccattcag tctgaaggaa 1410061 tccggcttta taaaggcggg gaggaattca gggctgattg cagtgcggac acgagtatca 1410121 attcggactt tgacctgctt gtcgtgacag tgaagcagca tcagcttcaa tctgtttttt 1410181 cgtcgcttga acgaatcggg aagacgaata tattattttt gcaaaacggc atggggcata 1410241 tccacgacct aaaagactgg cacgttggcc attccattta tgttggaatc gttgagcacg 1410301 gagctgtaag aaaatcggat acagctgttg atcatacagg cctaggtgcg ataaaatgga 1410361 gcgcgttcga cgatgctgaa ccagaccggc tgaacatctt gtttcagcat aaccattcgg 1410421 attttccgat ttattatgag acggattggt accgtctgct gacgggcaag ctgattgtaa 1410481 atgcgtgtat taatccttta actgcgttat tgcaagtgaa aaatggagaa ctgctgacaa 1410541 cgccagctta tctggctttt atgaagctgg tatttcagga ggcatgccgc attttaaaac 1410601 ttgaaaatga agaaaaggct tgggagcggg ttcaggccgt ttgtgggcaa acgaaagaga 1410661 atcgttcatc aatgctggtt gacgtcattg gaggccggca gacggaagct gacgccatta 1410721 tcggatactt attgaaggaa gcaagtcttc aaggtcttga tgccgtccac ctagagtttt 1410781 tatatggcag catcaaagca ttggagcgaa atacaaacaa agtcttttga gctttttcgg 1410841 taacatgcta tactcatttc ggatcactaa ctatttattg gagaaaggaa gttctagaag 1410901 atgcagctaa ctgaactttc catcaaaaat cagaatgtgt ttgtacagca ctatatagat 1410961 ggcaaagaag aaatgtcttc tttttttgat tacagtattc atcataagga catgtggcgc 1411021 gaaagactgg aagacttatc ttcccggttt ttcgcaagag aggaattggc ggcgtactta 1411081 acctcttacc ataataaatt cggttcaagt gcgatgcagt ctgctattga gaagctgaag 1411141 gacccgtcaa gtgccgctgt agtcggcgga cagcaggcag gacttttaac aggaccgctt 1411201 tacaccatac ataaaatcat ttcaatcatt gttttagcaa agcaacaaga aaaggaactg 1411261 caagtgcctg tcataccaat cttctgggtg gctggagaag accacgattt ggatgagatt 1411321 aattttgttc acacatctga agagaatggg cctgtgaaaa aaaagctgcc tcagtcttat 1411381 tggaagaaat catcagcagc gagtacatcg cttgatcagg aaaagtgtgc cgcgtggata 1411441 gatgatgttt ttgccgcttt tgaagaaaca gaccatacga atacacttct cgacaatgtg 1411501 aaacgatgtt taagggaatc tgttacgttt actgacttct ttgaactgct gatcgcggat 1411561 ttgttccaag aagagggctt agttttatta aattctgggg atccggggat taaaaagctg 1411621 gaaacggcca tgttccaaaa gattcttcga gaaaatgatg aactcgcccg ggctgtatca 1411681 gatcagcagg ccttcatgcg tcaagcaggc tacaaaccga ttatcgagtc cggaaaagag 1411741 caggcgaatc tgttttatga atacgaagat gagcgttttt taattgaaaa agataacggc 1411801 cgatttgtca tcaaagagct tgatctagga tggacgaggg atgaacttca tacacatatg 1411861 gaagaacatc cagagcgttt cagcaacaat gttgtaacga gaccgttaat gcaggaattt 1411921 ctcattccga ctttagcatt tattgcaggg cctggggaaa tcaattattg gggcgagctc 1411981 aaacaggcat ttgcggtgat gggcttcaaa atgcctcctg tcatgccaag gctgaacatt 1412041 acgatacttg agcggcatat tgagaaaaaa ctggctgaac ggaatatctc attacaagac 1412101 gcgattgagc gcggaacgga gaatcaaaga gagacatact tcgagcgcca gattccggaa 1412161 gagtttacgg cggtgatgga tcaggcgaaa agccaaattg aagcgattca caaaacggtc 1412221 cggcaggagg cgttaaaggt tgatcaaagc ttggaacctt tacttctgaa aaatgccgct 1412281 tttattcagg atcagcttca attcttagag cgcacggtga tgaagcgaat tgaagaaaaa 1412341 gaaggctacg tcttgaagga ttatgaaaga attcaaaata gcattaagcc gcttcttgcg 1412401 ccgcaagaac ggatttggaa tatcatgtat tatttgaaca ggtacggtcc aaaattcttc 1412461 acgacattca agaatctgcc attttctttt caaaatcaac atcaagttgt caaactttga 1412521 aataaagttt taaagaaccc tgactagttc agggtttttt tttatgggta aacagtgtaa 1412581 aatgaagttg tggagcgaag tggtgaatag tggtgagtta aggagagaaa gtggggcaag 1412641 agatcatgtt tatgggtgaa tatcagcata ccatcgatgc gaaaggccgc atgatcgtac 1412701 ccgctaaatt cagagaaggc ctaggtgagc aatttgtgct gactagagga cttgaccaat 1412761 gtctcttcgg ctaccctatg cacgaatgga aacaaattga agaaaaacta aaagctcttc 1412821 ctctcacaaa gaaagatgcc cgcgcgttta cccgtttctt cttttcaggg gcgactgaat 1412881 gcgaactgga taagcaaggc agggtaaata tcgcatcatc tctattgaat tacgccaaac 1412941 tggaaaaaga atgtgttgtt atcggggttt ctaatcgaat tgaattgtgg agtaaagtaa 1413001 tttgggaaca atacacagaa gagcaagaag attcatttgc tgaaattgct gaaaacatga 1413061 ttgggtttga tatataatga ttcttcgtgt ataacactct aaaaacaatt tcaattcatc 1413121 ctgataaaag gtgggaccaa cacaatatgt ttcaacacaa gacagtactt cttcgtgaaa 1413181 ccgtagacgg acttaatatt aaaccagacg gtacatatgt agactgcaca ctcggcggag 1413241 ctgggcatag tacatactta ttgcagcagt tatccgagaa ggggcgttta atcgcttttg 1413301 accaagatga tacggcatta cagcatgcta aagaagtgtt gtccgattat aaaggacagc 1413361 tcattctgat taaaagcaat ttcaggtatt taaaagaata tttgaatgaa caaggcgtta 1413421 cagaagtaga cggcatttta tttgatttag gggtgtcctc tccgcagctg gatacaccgg 1413481 agcgcggatt cagttaccat catgacgcac cgttggacat gaggatggac cagtcggcta 1413541 cgctttcggc gaaagaagtc gttaatgagt ggcgctatga ggatctcgtc cgtattttct 1413601 ttaaatacgg agaagagaag ttcagtaaac agatcgccag aaaaattgag gaggcaagaa 1413661 tgaagtctcc tattcaaact acgggccaac tggtcgatct aataaaagac gcgattcccg 1413721 ctccagcgag aaggagcggg ggacatcccg ctaaacgcgt gtttcaggca atcagaattg 1413781 ccgtaaacga tgaacttagg gtgtttgaag aagctttgga gcaggcaatt gaggttctga 1413841 agccaggggg cagggtatcg gtcattacct tccactcgct agaagacaga atttgcaaaa 1413901 ccacttttaa agaaaagtcg tcgcttccgg aacttcctcc gggacttcct gttataccgg 1413961 aagagtttga accggagctg aagctcatca cacgaaaacc gattacggca tctcaagaag 1414021 agcttgaaga gaacaaccgg gctcgttctg ccaagcttcg gattgctgaa aaaagaaaat 1414081 aacgaaacgc gaacgcaaaa ttaaaaggag gtcatcagcc tatgagcaat ttagcttacc 1414141 aaccagagaa acagcagcgg catgcgatca gtcctgagaa aaaagtgatt gtcaagaaaa 1414201 gggcttccat tactctcgga gaaaaagtgc ttcttgtcct ctttgctgcg gcggtgctca 1414261 gcgtatcgct tttgatcgta tcgaaggcgt atgcggcata tcaaaccaat attgaggtgc 1414321 aaaagcttga ggagcaaatt tcatccgaaa ataagcaaat tggtgacctc gaaaaaagcg 1414381 ttgctgattt aagcaaaccg cagcgcatta tggacattgc gaaaaagaac ggcttgaatt 1414441 taaaagataa aaaagtgaaa aacatacagg aatgattcaa atgccaaaaa agaataaatt 1414501 tatgaataga ggagcagcga ttctaagtat ttgtttcgct ctctttttct ttgtcatcct 1414561 ggggagaatg gcatatattc aaataaccgg aaaagcgaac ggcgaagtgc ttgcgacaaa 1414621 agcgacagag cagcatgaaa agaaacggac catcgaagcg agccgcggct cgattttaga 1414681 ccgaaaagga aaagtcattg cagaggacac agcgacgtat aaactgattg cgattctcga 1414741 taaaaaaatg accactgatg tcaagcatcc tcagcatgtt gtaaacaaag aaaaaacggc 1414801 ggaagcattg tctaaagtga taaacttgga caaggccgac atccttgata tcttaaataa 1414861 agatgcaaaa caagtcgagt ttggctcagc tggccgggat attacgtatt cacaaaagca 1414921 aaaaatcgaa aaaatgaaac tcccgggcat ttcattttta cgggatacaa aacgctacta 1414981 tccaaacgga gtatttgcat ctaatctaat cggctatgcc gaggttgatg aagaaacaaa 1415041 tgaaatttcc ggcgcgatgg gattagaaaa agtgctggat aagtatttga aggagcggga 1415101 cggatatgtg acatatgaaa gcgacaaatc cggctgggag ctcccgaaca gcaaaaataa 1415161 aattacagcg ccaaaaaatg gtgacaatgt atatttaacc attgaccaga aaattcaaac 1415221 ctttttggaa gacagcatga caaaagtggc gcaaaagtat aatccgaaaa aaatcatggc 1415281 cgcagtcgtt gatccgaaaa cgggcaaagt ccttgccatg ggacagcgcc caagctttga 1415341 tccgaacaag cgcgatgtga caaactacta taatgatttg atttcatatg cgtatgaacc 1415401 cgggtccacg atgaagatct ttacactcgc tgctgcgatg caggaaaacg tgtttaatgc 1415461 gaacgaaaaa tataaatcag ggacatttga agttggcgga gcacctgtta aggatcacaa 1415521 taacggtgta ggctggggtc cgacaacata tcatgacggc gtcctaaggt cgtcgaatgt 1415581 cgcttttgcg aaactggcga aagaaaagct gggatatgac cgcctcaatc aatatttgca 1415641 caaattcaat ttttaccaga aaacaggtat tgatttgcca ggagaagtct ccagcaaaat 1415701 caactttaaa tatgaatttg ataaggcgtc aactgcatat ggccaagcgt ctgcggtcac 1415761 accaattcag cagattcagg ccgcaacggc aattgcaaat gacggtaaaa tgatgaaacc 1415821 ttatgtcatt gaccatatcg ttgaccctga taaagataaa actatttatc aaaataagcc 1415881 ggaatcagcc ggaactccaa tttctgcaag tactgcgaaa aaggtgcggg atatattagg 1415941 agaagtcgtt acatcgaaga tcggaacagg gcaagcttat aaaatcgaag gttttgatgt 1416001 tgccgggaaa acaggtactg cgcaaatagc cggtaaaggc ggatatttag acggcacaga 1416061 taactatatc ttttcgttta tgggtatggc gccaaaagat gatcctgagc ttttaattta 1416121 tgttgctgta cagcagccgc aactaaaagc aggacaaagc agttcagatc cagtatcaga 1416181 aatcttcaat ccaacaatga aaaatagcct gcactaccta aacatcgaac caactgaaaa 1416241 atctgactca gataaggaag aaacaaaagc gcagacaatg cctgatttaa cagatcaaac 1416301 ggtagctgct gctcaaaaga aagcaaaaga ggagaatctc acaccaattg tcatcggcag 1416361 tgatgtcgct gtaaaagaac agtatccgaa agcggatgag gaagttctca ccaatcaaaa 1416421 ggtcttcctg aaaacgggcg gcaaaatcaa aatgcctgat atgacaggct ggtcgagaag 1416481 agaggttctg cagtacggcg agctcgcggg aattcatatt gaagtaagcg gacaaggcta 1416541 cgctgtcagc caaagtgtta agaaagacaa agaaatcaaa gacaaaaccg taatcaaggt 1416601 taagtttaaa aatcctgatt aaaaagaaag ccgtcgttat gcaggctttc tttttttatg 1416661 ccttcagagg agcatcgttc tacctgtcca aattcaggca taaaatgaaa caagcctaaa 1416721 taaggagtga acggtctctt gcgcgtctcg aatgtaacgg ttagaaaacg tttattattt 1416781 gttttgcttt ttggcgtgat cgtgtttctg atcattgata caaggctggg gtatgttcag 1416841 tttgtgatgg gcgaaaaact gacttcgcta gcgaaagatt cctggagccg gaacttgccg 1416901 tttgagccgg agagaggcga gattctggat cggaatggtg tgaagctcgc aacaaataaa 1416961 agtgcgccga ccgtattcgt cgtgccgcgc caagttcaga atccgatgaa aacgagcaag 1417021 cagcttgcgg cggtgctcaa tatgtcagaa gaaaaagtat ataaacatgt gacaaaaaaa 1417081 gcgtcaatcg aaaagatcac tcctgaaggg agaaaaattt caaatgagaa ggcgaaagaa 1417141 atcaaagcgc ttgatttaaa aggtgtgtat gttgcggagg acagtatccg tcattacccg 1417201 ttcggcagct ttttatctca tgtgcttgga tttgcaggaa ttgacaacca agggctcctt 1417261 ggacttgaag cctattacga cgatgattta aaaggggaaa aaggttctgt taagttttat 1417321 acagatgcca aggggaagaa gatgcctgat gaagcggatg actatacgcc gcctaaggat 1417381 gggcttgata tgaagctgac agttgattca aaggttcaga cgataatgga aagagagctt 1417441 gataacgctg aggccaaata tcatccggac ggcatgattg ccgtagccat gaatccgaaa 1417501 aacggagaaa ttttggggat gtctagcagg cctgacttcg accctgctga ttaccaatct 1417561 gttgatccgt ccgtctacaa tcgaaatctg ccagtatgga gcacgtatga accgggatct 1417621 acctttaaaa ttattacact tgcagcagcc cttgaagagc aaaaagtaaa tttgaaacgg 1417681 gatcaatttt atgataaagg gcatgctgaa gtggacggag cgagactgcg gtgctggaaa 1417741 agaggcgggc acgggctgca gacgtatctg gaagttgtgc agaactcctg caacccgggg 1417801 tttgttgaat taggcgagcg cttaggaaag gaaaagcttt tcaaatatat caaagacttt 1417861 ggttttggac aaaaaacggg gattgatctc caaggcgagg gaacaggcat cttattcccg 1417921 cttgagagag tgggcccggt ggagcaagca actacggctt tcggacaggg agtatccgtc 1417981 acgccgattc agcaggttgc agcagtatcc gccgctgtaa acggaggaac gctctataca 1418041 ccttatattg caaaggaatg gatcgatcct gttacgaaga aaacggtcaa aaaacaatca 1418101 ccaatcgcaa agaaacaagt catttctgag gaaacatcca aacaaatccg ctatgctcta 1418161 gaaagcgtcg tcgcagaagg aaccggccgc aatgcatttg tagaaggata tcgtgtcgga 1418221 ggaaaaacgg gaactgcaca aaaggttaaa gatggaaaat atcttgaaaa caaccatatt 1418281 gtatcattta tcggtttcgc gccagcagat gatccgagtc tagtcgtcta cgttgcggtg 1418341 gataacccga aaggcacgat tcagtttggc ggaacggtgg cagcgcctat tgtcggaaat 1418401 attatgagag acagtctgcc ggaacttggt gtgaagcccc ggaaaaatca aatcgagaaa 1418461 aaataccaat ggaacgacac aaaaacaata gaagttccga atgttgtagg gatgtctgtc 1418521 tcagatcttg agtcactatt ggtgaatctc aatgtggatg cttccgggaa agggagcaaa 1418581 atcgttaaac aatcgccagc tgccggaacg aaagtaaaag aaggctcaaa gatacgcgtg 1418641 tatttgactg aagaagatga aaaggaggca gccgattgat tcgggctgcc tattctttta 1418701 ttgcagaaaa aatgctgata tctttcaaga ttagctggat gtatcctttt atttacgcta 1418761 aaatatgaac tgtatgctta aaatcattac cacatcattt gatgtgactt caatgataaa 1418821 aagaacgaat tagaatgttg agaggtttga tacgatgaaa cttacaaagc tgcttacata 1418881 cttaacaacc gaaccttctg taaacgactc acaagaccct gaaataactt caattgagat 1418941 ggactccagg gaagtaaaga aagggagtct ttttgtatgt gtaaaagggt atacggtgga 1419001 tggccacgat tttgcgcaaa aagcagtaga aaacggtgca gcggctattg tggcagaaag 1419061 agaggtcgat gtgaatgttc ctgttattat tgtccggcag tcacttcgcg cgctcagcgt 1419121 tttgtctgat gcgttttacg gacagccgac gaagaagctt cagctgattg ggataacagg 1419181 gacaaacggc aaaacatcaa cgacccacat ggtcgatgag attctgaaaa aagcgggaaa 1419241 acgcacaggc ttgatcggta caatgtacat gaaaatcgga gacgaaacac ttcctgttaa 1419301 aaacacgact ccggaaagcg tcacgctgca gaaaacgttt aagaaaatga atgacaagca 1419361 cgttgacact gcaatcatgg aggtttcttc ccacgctttg tctttaggac gcgtccatgg 1419421 ctgtgattat gatattgccg tgtttacgaa tttaacacag gaccatctgg actatcataa 1419481 aacgatggat gagtaccggc atgcaaaaag cttgctcttt tcccaacttg gcggggcttt 1419541 caaccatgaa catccaaagc gtgccgtcct gaatgctgac gatgaggcga gcgcttattt 1419601 tgaaaaggta acagctgcgc atatctctac atacggaatt aaaaacgatg ctgatgtgat 1419661 ggcgaagaac atcagtatca ctgcacaggg cacaagcttt gatctcgtga caaacaaagg 1419721 cacgaagcac atcacgatgt ctctcgtcgg acaatttaat gtgtataacg tgctggccgc 1419781 tgttgcgaca tgtattgcag caggcatacc gtttgaaatc atcactgagg ctgttgaaga 1419841 attgcatggt gtaagaggcc gttttgaatt ggtcaatcag cagcaggagt ttcctgtcat 1419901 tgtagactac gcgcacacac cggacagcct tgaaaatgtg ctggagacat gcagagacat 1419961 gacggaagga aagctatttg tcgttgtcgg ctgcggagga gacagagata agacgaagcg 1420021 cccgaaaatg gctaaaattg ctgtggagct ggctgacgag ccgattttca cgtcagataa 1420081 cccgagaagc gaagatcctc gcgcgatttt aagagatatg gaagccggag tagagaacgc 1420141 atactatcac agtattgcaa accgcgagca ggcgatcttt ttcgcaattg ccaatgccaa 1420201 aaaaggcgac gttgtcctca ttgccggaaa aggacatgaa acctatcagc agatcggaaa 1420261 tgaaactttc gattttgatg atgctgaagt agcggcgaga gccattgttg aactcaataa 1420321 gaataagacg aattcatagg aaagagatgt tactgaataa tggagcttga aaagattttt 1420381 catatggaaa aaaatcatga atatgataac tacgtatgtc gtttgaaaga aacaggagga 1420441 gaaaaggaca atgcttgagc aagtcattct gtttacaatt ttaatggggt ttttaattag 1420501 tgttctgctc tctccgattc ttattccgtt tttaagaaga ttaaaattcg gccagagtat 1420561 tagagaagaa ggaccgaaat cacatcagaa aaaatcaggg acaccgacaa tgggcggggt 1420621 catgatcata ctttctatca tagtgacaac aattgttatg acacagaagt tttcagaaat 1420681 aagccccgaa atggtgctgc ttctgtttgt tacgctaggc tacggtttgc ttggcttttt 1420741 agatgattac atcaaggttg tcatgaagcg caatcttgga ttgacatcaa agcaaaagct 1420801 gatcggacaa attattattg cggttgtatt ttacgccgtg tatcattact acaattttgc 1420861 gacggatatt cgcattcctg gaactgactt atcatttgat cttggctggg cttactttat 1420921 ccttgtgctc tttatgctag tcggcggatc aaacgcagtt aacctgactg acggccttga 1420981 cgggttatta tccggtactg cggcgattgc ctttggcgcc tttgccattc tggcatggaa 1421041 tcagtctcaa tatgacgtag cgattttctc agttgccgtt gtcggtgcag ttctgggctt 1421101 ccttgtattt aatgctcatc cggccaaagt ttttatggga gatacgggat cgcttgcatt 1421161 gggaggagcc atcgttacca ttgccatttt aacgaaatta gagatcctgc tggttatcat 1421221 cggcggtgta ttcgttatcg agacattatc cgttattttg caggtcatca gctttaaaac 1421281 gacaggtaaa cgaatcttta aaatgagtcc gcttcatcac cattatgagc ttgtcggctg 1421341 gtctgaatgg agagtagtcg tgacgttttg ggctgcggga cttttgcttg ccgttttagg 1421401 aatttacatc gaggtgtggt tataagtgga aaatgatcaa tttttacaga aacagcattt 1421461 tttaatcctt gggcttgcga aaagcggata tgcggcggcc tccattcttc atgaaaaagg 1421521 catttatgtt gcagtcaatg atcaaaagcc ttttgaagaa aatgaaccgg cacaaaagct 1421581 ttctgaaaaa ggaatcgaag ttgtttgcgg agagcatcca gtttctctgt tcgatcagca 1421641 tcaaatcacg attctgatca aaaacccggg aattccttat gaaaatatca tggttcagga 1421701 agcagagaaa cgaggtattc cggtttggac ggaaattgag ctcgcttact acctgaccag 1421761 cgccaagttt atcgggatta ccggatcgaa cggtaaaacg accacgacaa cgctaattta 1421821 cgaaatgctc aaggctgact cgcaaaaagc actgattgcc ggaaacatcg gcacagtcgc 1421881 aagtgaggtt gcctatcatg ctgatggaga tgaatggatc gttaccgaac tgtcttcgtt 1421941 tcagctgatg ggaacacacg ctttcagacc ggaaatcagc ctgattttaa atgtatttga 1422001 cgcccatctg gattatcacc atacgcgcga aaactatgaa aaagcgaaac agaaagtgta 1422061 ccttcatcag actgcttcag ataaagctat tgtcaaccag gatgatgaaa ccgtcgtgcg 1422121 tcttgctgaa gccggaaaag ccgaaatcgt cccattttca gtcagcaaaa cgcttgaaca 1422181 gggcgcatat gtaaaagaca gtatgattat gtttaacggc gaagccattc ttcctctgga 1422241 agaggttgta ctgcccggtg ctcataacct ggagaacatt ttagcagcta ttgcagttgt 1422301 gaaaacggca ggagcatcca atgaggcggt taaaaaggtg ctgacaagct ttactggtgt 1422361 gaagcaccgc ctccaatatg tcacaactgt gaatggccgc aaattttata acgacagtaa 1422421 agcaacaaac attctggcga caagcaaggc gctttcagct tttgataagc cggtcattct 1422481 gcttgcgggc ggactggatc gcggaaatgg ttttgatgac ttgaaacctt atatgaagca 1422541 tgtcaaagca gtgcttacat ttggccagac ggcgccaaaa ctcgagaaac tcggcaatga 1422601 actgggaata caacatgtca aacgtgtcga taatgttgaa caagcagtat ctgcggcgtt 1422661 tgcgctctca aatgaaggag atgtcatcct gctgtcaccc gcgtgtgcga gctgggatca 1422721 attcaaaaca tttgaagaac gcggtgacat gtttatagat gccgtgcata tgcttaagta 1422781 agggcttgtc ttgaagtaaa tcggcagccc taatgacttt aagcttgggg tgtcgattgc 1422841 tttgactact aaaaaaacat cgcctgattt gttattggtc atcattacgt tattattatt 1422901 aacaatcgga ttaattatgg tgtacagtgc gagtgcggta tgggcggatt ataaatttga 1422961 cgactcattc tttttcgcga aacggcagct tttgtttgcg ggaatcggcg tcattgctat 1423021 gttttttatc atgaatgttg attattggac ttggaggaca tggtccaaat tgctgatggt 1423081 tatctgcttt ttccttctgg tgcttgtttt gataccgggc gtcggaatgg tgcggaacgg 1423141 ttcaagaagc tggatcggag tcggagcatt cagcatacag ccttcagagt ttatgaagct 1423201 tgcgatgatt gcattccttg ctaaatttct ctctgaaaaa caaaaaaaca tcacatcgtt 1423261 cagacggggg ttcgtccctg cacttggcat cgtgttttca gcatttttga ttatcatgtg 1423321 ccagcctgac ctcggaacgg ggacagttat ggtcggaact tgtattgtca tgatttttgt 1423381 agccggcgca cggatcgccc atttcgtctt tctcgggctg atcggcctca gcggatttgt 1423441 cgggctcgta ctatcggctc catatcggat aaagcggatt acctcatact taaatccatg 1423501 ggaagacccg ctcggaagcg gatttcagat cattcaatcg ctttatgcag tggggcccgg 1423561 cgggttgttc ggaatggggc tcggacaaag cagacagaag ttcttttatc tgcctgagcc 1423621 gcaaacagac tttattttcg ccatcttgtc agaggagctg ggctttatcg ggggaacact 1423681 tattttgctc ctcttcagcg tcctgctgtg gagaggaatc agaattgcgc ttggtgcgcc 1423741 tgatctgtac ggaagctttg tcgcagtcgg cattatttca atgattgcca ttcaagtcat 1423801 gataaatatc ggcgtagtca cgggcctgat tcctgtaaca ggcatcacgc tcccgtttct 1423861 gagctacgga ggctcttcat tgactctaat gctgatggca gttggtgtgc tgctgaatgt 1423921 aagccgctac tcgaggtatt aacgaatgta tttccaagcc tcctgtctaa catgaagctt 1423981 ggaaacaatt gatgcgataa ccctgtccaa caaaacaggg ttatcgttat gttatagaga 1424041 aacttagact gggggaaaaa agaaatgcga attgcaataa gcggaggcgg tacaggggga 1424101 catatttatc ctgctcttgc ttttattaaa gaagtgcaaa gacgtcatcc taatgtggaa 1424161 tttttatata tcggaacaga aaacgggctg gagaaaaaaa ttgttgagcg ggagaatata 1424221 ccgtttcgtt caattgaaat tacaggattt aaaagaaaat tgtcatttga aaatgtcaag 1424281 actgtgatgc gttttctgaa gggcgtcaaa aagagtaaat cgtatttagc ggaatttaag 1424341 cccgatgccg taattggaac gggcggttat gtatgtgggc cggttgtcta tgccgctgcg 1424401 aaaatgggaa ttccgactat tgtccacgaa caaaacagcc tgccgggcat cacgaataag 1424461 tttctttcaa aatatgttaa taaagtagcg atttgttttg aagaagcgaa atcacatttt 1424521 cctagcgaga aagttgtatt tacgggaaac ccgagagcct ctgaagtcgt ctcaataaag 1424581 acgggacgat cattggctga atttgggctt tctgaagaca aaaaaacggt cttaattttc 1424641 ggcggaagcc gaggcgctgc accgattaac cgcgctgtca ttgacatgca ggatgtgctg 1424701 aaaacaagag actatcaagt gctgtatatc accggtgaag ttcactatga aaaagtaatg 1424761 aatgagctga aaagcaaggg tgccgctgat aatatggtca caaagccgtt tcttcatcaa 1424821 atgcctgagt atttaaaggc cattgatgtc attgtggcca gagccggtgc gacaacgatt 1424881 gccgaaatta ctgctctcgg aatcccaagt gttctgatcc caagtccata tgtgacagcg 1424941 aatcaccagg aggtcaatgc gaggtctctt ggccagcatg atgcggcgat tgtactgaaa 1425001 gaaacagagc tcagcgggga gaagctgatt gaagcgctag accggattgt actgaatgag 1425061 caaacgttaa aggaaatgag cgaacgaaca aagtcactcg gtgttcctga cgcggctgcc 1425121 cgtttataca gcgtactcga ggaattaaaa aaatagtaga aaagcaaatg gaatgcggag 1425181 gtttacgatg gagaaagtga tacaggaatt aaaagaacga gaagtcggca aggttcttgc 1425241 aaatgaaccg ctcgcgaatc atacaacgat gaaaatcggc ggacctgcgg atgtattggt 1425301 cattccaagc agtgtggatg ctgttaaaga catcatggac gtgattaaaa aatatgatgt 1425361 gaagtggaca gtcatcggcc gcggatcaaa tcttcttgtt ttagatgaag gaattagagg 1425421 cgtagtgatc aagctggggg cgggtcttga ccatttggag cttgaagggg aacaagtaac 1425481 agtcggaggc ggttattcgg tggtccgcct tgctacatca ttgagcaaaa aaggcctgtc 1425541 cggtttggaa tttgctgccg gcattccagg atcagtcggc ggagcggttt atatgaatgc 1425601 cggcgctcac ggttctgata tgagcgagat cctcgtcaaa gcgcatattt tatttgaaga 1425661 cggaacgatt gagtggctga caaatgagca gatggatttc agctacagga catctgtact 1425721 gcaaaagaaa cgcccgggcg tttgccttga agctgttttg cagcttgagc agaaggataa 1425781 ggaatcaatc gttcagcaaa tgcaaagcaa taaagactat agaaaaaata cacagccgta 1425841 ttcaagccct tgtgcgggaa gcatattcag aaatccgctt ccgaatcatg ccgggaacct 1425901 tgtagaaaaa gcaggcttga aaggatatca aatcggcggt gcaaagatat cggagatgca 1425961 cggaaacttc atcgtcaatg cggggggagc atcagcaaaa gatgtgcttg atctcattga 1426021 ccatgtgaaa aagacaatcc gtgaaaaata cgagattgat atgcacacag aggttgaaat 1426081 catcggcgga aatcgctgat tcaagttctg actgaagctg ttcatatgat atactgtaag 1426141 caaacgacaa acggcatcat agtatgccgt ttgttttgga atagacagac ttttaacagc 1426201 tgtttcattt gaatgaggtg aacaggcaat gaacccgggt caagaccgag aaaaaatcgt 1426261 taacattgaa gagcggatcc ctaaaattaa agagcagagg aaacaaaagg caaaccgccg 1426321 tctcatttca tttattatgc tcttttttat tatggtgctg atcattgtgt acctgcaaac 1426381 accaatcagt aaagtatcaa caatctctgt tacagggaat gaaaatgtat caaaaaagga 1426441 aattatcgac ctttccgata ttaacagcgg agatactgag ttttggagtt tggacaagca 1426501 aaaaacagaa aagaagattc agcaaaataa attagtgaaa aaagcggaga tcagcaaatc 1426561 gcttcctaat aaaatcaaca ttgcaatcga agaatataaa gcgattgctt atttagaaaa 1426621 agacgatgtg tactatgaag tgcttgaaaa cggctcagtt ctgccaaacg aagtaacgcc 1426681 ggatgatgcc ggaccgattt tagtgaattg gacaaacgcg aagaagcggt ctcaaatggc 1426741 caagcagctc gatgcgttgt caaattcgtt aaaacagtcg atttcagaaa tttattatac 1426801 gcctgtaaaa atggatgaaa accgtattaa gttgtacatg aacgacggtt atgttgttac 1426861 ggcatctatt aaaacgtttg cagaccgaat gaagacgtat ccttctatca tctcacagct 1426921 aagcagcaat aaaaaaggaa tcattcattt agaagttgcc acctattttg aagagtttgg 1426981 gaaaaacgat aaagctgcta aaaaggaaga tgaaaattga ggggcaaatc agcagtcctt 1427041 ctttccttga ttatgcttat cgcaggtttt ttgatttcat tttcttttca aatgacaaaa 1427101 gaaaacaaca aaagcgcggc tgagacggaa gagtggaaaa aagaatatgc gctgagagat 1427161 gaactgctga aacaagagaa agaaaataag aagtttgaaa aagaattata tcaaaagcaa 1427221 aacaaagtcc gccaggcgga aaataagctg aagaaagaga agtcggaata ctataatgtc 1427281 ctcgaagata cagaaaaata caggatgtat attggggaag tcggtgtgca gggagaaggc 1427341 gttgaggtga cattggaaga tgcgtcatac ataccggaag gggagaatgt gaatagttac 1427401 atcgttcacg aaagccatat cttccaagta gtaaacgaac tgtatatctc aggagcggca 1427461 gctgtcgccg ttaatggaca gcgtttgacg catgattcgt atatcaaatg caatggtcct 1427521 gtggtaacgg tagacggggt gcagcatccc gctccgttta cggtatccgc tattggagat 1427581 ccagatgtcc tgctgccctc gttaaatatc gctggaggcc taattgatca gctgtcaatg 1427641 gatcatattt ctgtgtcggc agaaaaagag aaaaacgtac aaatgaaacc gattctgaaa 1427701 acgaaggaat gactgaaaaa gcgggtgaaa tagattgaaa ataaagcgtt ccttcataag 1427761 catcagtgtt cttatggtca tcttcggcct gatgatatct gttcagttta attcgttaaa 1427821 gcaccccaaa gtccgggata caagagatat gtgggatatt agggaagagc tgacatcaga 1427881 gcagaagaag caggaaaagc tgctggctga aataaacaaa tatgacaaat tgctgaatag 1427941 ctattcgcaa acgaaagaaa tgacaaaaga aaccgcgcta aataatacct tgcaatcctt 1428001 aaaaaaaaca gccggcatga ccgatataac aggtagcgga attgtcatta cgatttcccc 1428061 gcttttttct gaaagcttaa caggagagcc gatcgaaaat ccgcctccgg atttgctgaa 1428121 aaagctgata aatgaactca actcctacgg tgcagagcat atctcgatta atgagcgaag 1428181 agttgtgaat catacagtca tcagagatat aaacggcact acaaaaatag acggatacgc 1428241 ccttgacgat tatcctttaa cagtaaaagt gcttgccaaa gatccggaca tgttacacag 1428301 cagagtgaag gggtcaggcc ttgaggatct ttttgcatct gaaaatttag cattaaaagc 1428361 cggtaaatct gaaagcaaac taacattaaa agcatatgac agaccactgg acgtacaaca 1428421 gctgaaactg cttaaagact gaaaaggagg agaattgtca tgtggctgcc cgtgttggga 1428481 ctggtgctcg gaatagcgat tggactaatg acaaacttaa cgataccgag tgaatactca 1428541 aactatttat cgcttgcggt gcttgccgca cttgatacat taatcggcgg aatcagggcg 1428601 catttacaag gtacatatga tgaaatggta tttgtttccg gtttcttttt taatattata 1428661 ttggcaataa gtttagcttt tctgggagtc catcttggtg tagacttgta tttagcaggt 1428721 atattcgcat ttggagtcag attatttcag aatatagccg ttatcagaag aaatctacta 1428781 acaaagtgga ctctttctaa aaaaaataaa aaaaatgtga tataaaagag gatatacata 1428841 ggatataacg aatattttca ataaacataa aatgtgaaaa gcacataaaa atattctgtt 1428901 gttatttttt gttacacact tgtaaagcca cattcattgt attgttgttc cgcaaataat 1428961 agaatagaaa tgatcgaaat gtgaggaggt gccatagaat gaacaacaat gaactttacg 1429021 tcagtcttga catcggtacg tccaatacaa aagtgatcgt cggagaaatg acagatgatt 1429081 cccttaatat tatcggtgtg ggaaatgtac cgtctgaagg gttgaaaaaa ggctcaatcg 1429141 ttgatataga tgagaccgtt cattctataa gaaaagcgtt tgaccaagct gaaagaatgg 1429201 taggttttcc gcttagaaaa gctattgtcg gcgttaatgg aaattatatc aatattcaag 1429261 atacaaacgg tgttgtagca gtttccagtg aaaataaaga aattcaggtt gaagatgtac 1429321 gccgtgtcat ggaggcggca caggttgttt ccgtaccgca tgaacagctg attgttgacg 1429381 tcattcctaa acagtttatc gtagatggaa gagatgaaat caccgacccg aaaaaaatgc 1429441 tgggtgtgcg tttagaagta gagggcacct tgatcaccgg ttcaaaaaca atcttacata 1429501 acttactccg ctgcgttgaa agagctggta ttgaaataac tgatatttgc cttcagccgc 1429561 tggcagccgg ttctgctgca ttatcaaagg acgagaaaaa ccttggtgtg gctctcattg 1429621 atataggggg agggtcaaca accattgccg tattccagaa cggacatctc acttctaccc 1429681 gtgtcattcc tctcggaggc gaaaatatca ccaaagatat ctccatcgga ttgagaacgt 1429741 caacagaaga agcagaacgc gtgaaaaagc aacttggaca tgcctactat gacgaagcct 1429801 cggaagatga aatatttgag gtaaccgtta taggcaccaa tcaaaaacaa acatttacac 1429861 agcaagaagc agcgaatatc attgaagcga gagtagagga aattcttgaa attgtttcag 1429921 aagagcttcg cagtatggga attaccgatc tgccgggagg cttcgtgctg acaggaggac 1429981 aagcagctat gccgggtgtc atgtctttgg cacaggatgt gctgcaaaac aatgtcagag 1430041 tggcaagccc gaattatatc ggtgtaagag atcctcaata tatgacggga gtgggcctga 1430101 tccaattcgc ctgccggaat gcaagaatcc aaggcagaaa aataggcttt aagatgcctg 1430161 aagaagcgat acaggaaatc gcagtctcat catctgagga acaagagcag catcatcacc 1430221 aaaatgaggt gcagcagcgg ccaaaaggaa aacaaaaaac acaagccgaa cataataaac 1430281 agagcaaaat gaaaaaacta ttaagcatgt tttgggaata gatagatagt cattcggcag 1430341 attaggagga tttagcatgt tggagttcga aacaaacata gacggcttag catcaattaa 1430401 agtaatcgga gtaggaggcg gcggtaacaa cgccgttaac cgaatgattg aaaatgaagt 1430461 gcaaggagta gagtatatcg cggtaaacac ggacgctcaa gctcttaacc tgtcaaaagc 1430521 agaagtgaaa atgcaaatcg gcgcaaagct gactagagga ttgggagcag gtgcgaatcc 1430581 ggaagtcggg aaaaaagccg ctgaagaaag caaagagcag attgaagaag cacttaaagg 1430641 tgctgacatg gtattcgtga cagctggtat gggcggcgga acaggaacag gtgccgcacc 1430701 ggttatcgca caaatcgcga aagacttagg cgcattaaca gtcggcgttg tgacaagacc 1430761 gtttaccttc gaaggacgca aaagacagct tcaggctgca ggcggaatct cggcaatgaa 1430821 agaagcggtg gatacactga tcgtgatccc gaacgaccgt atccttgaaa ttgttgataa 1430881 aaacacaccg atgcttgaag cattccgcga agcggataac gtacttcgcc aaggggttca 1430941 aggtatttct gacttgattg ctacacctgg tcttatcaac cttgactttg ctgatgtgaa 1431001 aacaatcatg tcaaacaaag gatctgcttt gatgggtatc ggtattgcta ctggggaaaa 1431061 tcgcgcggca gaggcagcaa aaaaagcaat ttccagcccg cttcttgaag cggccattga 1431121 cggtgcgcaa ggcgtcctca tgaacatcac tggaggaaca aacctcagcc tatatgaggt 1431181 tcaggaagca gcagacattg tcgcttcggc gtctgatcaa gacgtaaaca tgattttcgg 1431241 ttctgttatt aatgaaaatc taaaagatga gattgtggtg acagtgattg caaccggctt 1431301 tatcgaacaa gagaaggacg tgacgaagcc tcagcgtcca agcttaaatc aaagcatcaa 1431361 aacacacaat caaagtgttc cgaagcgtga gccaaaacgt gaggaacctc agcagcagaa 1431421 cacagtaagc cgtcatactt cacagccggc tgatgatacg cttgacatcc cgacattctt 1431481 aagaaaccgt aataaacgcg gctaatgtaa aggacaaaat cgttttcgat tttgtccttt 1431541 tttgtttttc tcttcacact ttccttctta taaagtcttt ttccctattg cttccttcgc 1431601 gagctcgatt atggatggtt tacgttttgg aaaaagtaag gtatcctagt tcgtacaaag 1431661 ttttatgaaa attaaaacaa ttataaaagg caataaagag gaggaccacg atgattttgc 1431721 agcttgacaa tgtctcacta aaacggaatg ggaaatggat actgaaagat attcattgga 1431781 aggtggaaga aaaggaaaat tgggtgcttt acggcctaaa tggcgccggg aagacagcgc 1431841 tgttaaatat gctttgctca tattattttc caacatcagg cgagatgcag gtgctcggcc 1431901 atgaatttgg caaaacagag cttggggaaa agctcagacg taaaattggc ctcgtctcag 1431961 cagctcttca gcaaaaattg tatccggcag attcagcttt tgaaattgct ttgagcggag 1432021 cttacgcttc gattgggtta tatgaaacgc caagtaagga aaccagggaa aaagcgatag 1432081 gtttgttaga ggacttggga gcaattgaat atgccgatcg ccgctatgaa accctttctc 1432141 aaggggaaaa acaaagagca ttgattgcta gagcactaat ggccgatccg gagctgctga 1432201 tactggatga accagtcaca ggactggatt ttattgcccg ggaaaagctg ttagatacga 1432261 ttacatacat tgcaaacaaa gaaaatgcac catctatcct ttatgtgact catcatgctg 1432321 aagaaatttt gcctgtcttt gataaagccc ttttattaaa acagggagag gtttttggat 1432381 ccggagaaat aaaggaaatg cttactgatc aaatactttc cgcttttttt gatacgccaa 1432441 tccatgtatt atggaatcag gatcggccgt ttttaacaag agctgagccg ataacgaatg 1432501 cctgacaaat atatatagat tcatcctagg ggtgctttgc gaagctgaga gagactttgt 1432561 ctcaaccctt ttgacctgat ctggatcatg ccagcggagg gaagcggtga aaagcggagt 1432621 acatcggact ccgtttgttt ttattaagcc gtttcatcac atttgaaacg gcttttttga 1432681 ttttaaagaa taggagcgga tttacattgg atcaacaaat atactctttg caaaaaaaag 1432741 tggaagaaca taaggaggag cttattcagc ttgcgaaaac gctgatttct tatcaaacac 1432801 ctgctccgcc tgcaagaaat acagagggca ttcagtcttg gattgcggga tatttaaatg 1432861 aattgggatt ctcgatcgac aaatgggatg tgtaccctgg agatcccaat gttgtaggga 1432921 agctaaaagg aacagattca gcagattatt atagcctgat tatcaatggc catgtagatg 1432981 tggcagaggt aaaagaggat gaagaatgga agcacgatcc gtttcatccc attgaaaaaa 1433041 acggtctctt aatcgggcga ggcgcttccg atatgaaggg cggaatggct tgtgtgctgt 1433101 ttgctgtcaa attaattcgt gaagcaagca ttgaacttcc aggtgatctg attctgcaat 1433161 cggttattgg ggaggaagtt ggagaggccg gcacacttga atgctgcaag aggggctacc 1433221 acgctgattt tgcaattgtc gcggatacga gcgatatgca tattcaaggc caaggcggtg 1433281 tcattacagg ctggatcgaa atcaaaagca gtcaaacatt tcatgatgga acgagacgga 1433341 atatgattca tgcaggcgga ggaacattcg gagcaagcgc aattgaaaaa atggcaaaaa 1433401 tcattgcggg gctcggtgaa cttgagcgcc actggtctat tatgaaaagt tatcccggtt 1433461 ttaaaccagg cacaaatacg attaacccgg cagttataga aggcggcaga catgcggctt 1433521 ttatagcgga cgaatgccgg ctgtggatca cagtccattt ttatccgaat gaaacccatg 1433581 accaagtggc agcggaaata gaagattacg tcaatcggct gagtgacagt gatatttggc 1433641 ttagggaaaa ccgccctgta ttcaagtggg gaggctcatc tatgatagaa gacaggggag 1433701 aaatttttcc ggcattggaa gttgaccctg gccacccagg cgtcttagcg ctaactgcct 1433761 ctcatcagaa agtgaaacgg gagtgtccaa ttattgacgt ttctcaatca gttacagatg 1433821 gcggatggct gtatgatgcc ggtattccat gcgtaatata cggtcctgga gatctgcaca 1433881 atgcacactc tgtgaacgag aaggtatcga ttgagcagct agtagagtat acaaaaatta 1433941 tactcgattt tatcatcagc tggtgcagcc ggaaaaaaga acaatgacat gaaaatttct 1434001 tcttgctgac aaggttcagc ctgcccgttc atatacttga acaaaaggac ggaaaaagga 1434061 cgtgatggaa tgatcagcat ttcagaattt caggtaaagg atgtcgtcaa tgtctcaaac 1434121 ggaaaaaagc tggggagtat tggtgatatt gatatcaatg tgaccactgg aaaaattcag 1434181 gcgatcatac tcggaggaaa tgggaaagtt ctcggatttt ttggaaaaga agaggaattg 1434241 gtcattccat ggcgaaatat agtaaaaatc ggggaagatg taatcttagt ccgattaagt 1434301 gaaccacatg cataaacctg cttgtctgcc gcagattggc aaatgccgga agtctcgatt 1434361 cttccggcac atttcattta gaaatatgca aatcggcgct caacgaatgc agtaagatgt 1434421 ggtaaaataa gtgggaaatt ccgctttttt aaatgtttgt cgaaaggttg gatcatcatg 1434481 aatacatatc acccattcag tcttaccaca ccctcgacac tcatgataca agactgggct 1434541 caaacgaatc aaaacaacaa agaggtcatt gccggattta cgacaaaaaa cggcggtgtc 1434601 agccaaaagc cttttgaatc gttaaataca ggattgcacg ttcatgacaa agatgcagat 1434661 gtagttaaaa atcgtgaata tattgccgat atgtttaata ctgatttgca gtcttgggta 1434721 ttcgctgatc agacacatga taatcgcgtt cagaaagtga cgcagaggga taggggaaaa 1434781 ggcgcccgtg agtatcacac ggctctaaaa gcaacggacg ggatctatac aaatgaaaaa 1434841 aatgtatttt tagcattatg ctttgctgat tgtgtgcctc ttttctttta tgatccggtt 1434901 aagtcgcttg tcggagtcgc ccatgccggg tggaaaggca ccgtcaaaca gattggcaga 1434961 gaaatggtga agcaatggac tgagaaggaa ggttcaaatc cctcagatat ttacgctgtt 1435021 attggcccgt ctatcagcgg agcatgctat acggtagacg accgcgtcat ggatgctgtc 1435081 cgcgcattgc cggtttcagc agaccttgcc gccaatcaga cggcaaaggc acaatatcag 1435141 cttgatctga aagagctgaa ccgtcttata ctgatggaca gcggtttggc aagtgaacaa 1435201 atttctgtca gcggtttatg cacggaaagc gagccgtctc ttttctattc tcatcgccgc 1435261 gatcagggga aaactggacg gatgatgtcc tttatcggaa tgaaggaggc ataaaagatc 1435321 ttgcgtgttg ttgataattt acgacatata aacgaacgaa taaacgaagc atgtaacaga 1435381 tcgggccgca gctccgatga agttacggtt attgcagtca caaaatatgt atcacctgaa 1435441 agagcacagg aggcagtaga tgctggcatc acctgcctcg gagagaatcg ggatgcggaa 1435501 ctgctccgca aacaggaatt gatgaaaggg aatccggaat ggcattttat cggcagtctg 1435561 caatcaagaa aagcaaaatc tgtcgtcaat tcggtttcct atatccattc cctagaccgg 1435621 ctctcattag cgaaagaaat tgaaaaacgg gctgaaggta ctgtacgatg ctttgtgcag 1435681 gtcaatacct ctcttgagcc ttctaaacat ggcatgaaaa aagaagaagt cattccattc 1435741 atacaggagc tttccggttt cgaacatatc cttgttgccg ggctgatgac aatggctccg 1435801 ctgactgatg atcaagatca gatcagaagc tgtttcaggt cgctgagaga actccgtgac 1435861 caggttcaga agctgaacca gccgaacgct ccgtgtactg aactgtcgat gggcatgtca 1435921 aatgattttg aaattgcaat tgaagaagga gctacttata ttagaatcgg ctcatcgtta 1435981 gtcggaaatg aaacaggggg tgtacagcaa tgagtatgaa aaataaactg aaaaactttt 1436041 tctcaatgga agatgaagaa tacgaatatg aatatattga gacagagcgg gaatctcatg 1436101 aggagcatga gcaaaaagaa aagccggctt acaacgggaa taaacctgcg ggcaaacaga 1436161 atgtagtgag cttgcaaagt gttcagaaat cctctaaagt ggtgttgagt gagccgcgcg 1436221 tttatgcgga ggcgcaggaa atagccgacc atttgaagaa ccggcgggca gttgtcgtca 1436281 atcttcagcg gatacagcat gaccaggcga agcggattgt tgacttttta agcggaaccg 1436341 tttatgccat tggcggcgat attcaaagaa tcggctcaga tattttcctc tgcacgcctg 1436401 acaacgtaga tgtatcaggc acaatttctg agctcatatc tgaagacgaa catcagaggt 1436461 ggtaaagcga gatgatcctt tatcaagttt tttcggtttt aagcttatta atcacaatat 1436521 actcatttgc cctgatcata tatattttta tgtcatgggt gccgagtacg agggaaacag 1436581 cagtcgggcg ttttttggct tcgatttgtg aaccatatct cgaaccattc agaaaaatca 1436641 tccctccgat tgcaatgctg gatatttcac caatcgtagc aatacttgtg cttcggtttg 1436701 cgacaaccgg cttgtgggga ctttatcgca tgattgcgtt ttaatgtgac agtttgatag 1436761 gggcttggca gcagccaagc ctctttacat agaagggaaa gacgatgagc gatatatatc 1436821 agcacttcag aaaagacgag cgggccttta ttgatcaagc gctcgaatgg aaaagaattg 1436881 tccaggagca gtaccggatg aagctgaccg actttttaga tccccgagag caggtcatcc 1436941 tctctgctgt tacgggacag gcagatgtcg ggcttgcctt ttccggcggc tatgacagag 1437001 cggagcggaa acgggcgatt ctgtttccag agtacattac tccggaagaa tcagattttg 1437061 aactgcaggc gtttaacgtc cgttatgctg acaagtttgt ctcagtagat catcgttctc 1437121 tgcttggtgc attaatgggc ataggattaa agcggcaaaa attcggtgac atcgtgtttt 1437181 ctgagacagc agtgcaattg attgtctcag ccgataccgc tgattttgtg gctgcacagc 1437241 tgacccaagc aggcaaagcg gcggtcagcc tagagaaaat cgacttgtca gaccttaaca 1437301 ttccagcagt tgatgtcgaa ataagagatg acacggtttc ttctttaagg cttgacgccg 1437361 tctgcgcctc tatgagcagg caatcccgcc agaaatcaca gacgcttgtg aaaaacggcc 1437421 ttgtgaaagt gaactggaag gtggttgaag atccttcata catagtcgcg gaaggggaca 1437481 tgctgtctat cagaggtttt ggccggtgca gcttaacaaa aatcgaagga aaaaccaaaa 1437541 aagacaaatg gagagttacg tttgaacgac aaaaatagtc ggtttttcag tttttttctc 1437601 catctgtgcg aaatttgttt tataatgtga actagataac cgtactgaaa tgtaaaaatg 1437661 gaggtggcat catgccatta acgccaaatg atattcacaa caagacgttt acaaaaagtt 1437721 ttcgcggata tgatgaagat gaagtaaatg aattcctagc ccaagtcaga aaagattacg 1437781 aaattgttct ccgcaagaaa actgagcttg aagcgaaagt caatgagctt gatgaaagaa 1437841 tcggacactt tgccaatatt gaggagacat tgaataaatc aattttagtt gctcaagaag 1437901 cggctgaaga cgtaaaacgc aattctcaaa aagaagcaaa gctgatcgtt cgggaagcgg 1437961 agaaaaacgc tgatcgcatt atcaacgaat cgttatcaaa atcaagaaaa attgcaatgg 1438021 aaattgaaga gctgaaaaaa cagtctaaag tgttcagaac acgtttccaa atgctgattg 1438081 aagctcagct tgatcttctg aaaaatgacg attgggatca tctccttgag tatgaagtcg 1438141 acgctgtatt tgaggaaaag gaataaattc tctgattatc ttgacatttt cttagcttgt 1438201 cgaatataat acgttcataa attcagatga aaaaacggtt gaaagggaca gtcatgtttc 1438261 cttcaggcct tcatagcgac ccggagatgg tgagagtccg ggatggccgg aatcatgtag 1438321 atcagccctt tagtttcctt gctgaactca cagtaggtta ggacgttcat cacgttacga 1438381 tgctcaagag gaaaaagtgt atgcttgctt tttctaaaag ggtggtaccg cgagataagc 1438441 tttctcgtcc cttatgggat gagagggctt tttttatttt ctgaaaaaat gcagtggagg 1438501 aatgaaaatg gattttaaag acacgctctt aatgccgaaa acagatttcc cgatgcgtgg 1438561 aaatttgcca aaccgtgagc ctgacattca aaaaaaatgg gaggaagaag atatctaccg 1438621 tcttgttcag gaacggacga aagaccgccc gaaatttgtt ttacatgacg gacctccgta 1438681 tgcaaacggc gacatccata tgggccatgc acttaacaag attttgaaag acttcattgt 1438741 ccgctataaa tcaatgagcg gctacaacgc accgtatgtg ccgggctggg atacacacgg 1438801 attgccaatt gaaacagctc tgacaaaaaa caaaaaggtc aaccgcaaag aaatgtcagt 1438861 agcggaattc cgcaaactat gcgaagagta cgcttggaag caaatcgagg gacagcgtga 1438921 gcaattcaaa cgtcttggtg tccgcggtga ctgggaaaac ccatatgtga cattaaaacc 1438981 ggaatacgaa gcgcagcaaa tccgcgtatt tggtgaaatg gcaaaacgag gctacattta 1439041 caaaggcctt aaaccggtta actggtcacc ttcaagtgag tctgctctgg ctgaagccga 1439101 gatcgaatat caagataaac gttcagcatc tatttacgtc gcttttggtg taaaagacgg 1439161 aaaaggcgtt cttgaaaacg gcgagcgcat catcatttgg acaacaacgc cgtggacaat 1439221 tccggcgaac ctcggaatct cagtgcaccc tgatcttgag tacagcgtga ttgcagtagg 1439281 tgaagaccgc tttgttgtag caagtgcctt agtcgaaaat gttgcatcgg catgcggatt 1439341 tgatcagtat gaagtgacaa gaacggtcaa agggaaagac cttgagaaca ttatcgctga 1439401 acacccgcta tatggcagag actctctcgt tatgcttggt gaacacgtaa caactgatgc 1439461 cggaacaggc tgtgttcata cagcgcctgg acatggggaa gatgacttta tcatcggcca 1439521 aaaatacggt ttagatgtgc tttgcccggt cgatgaaaaa ggtgtaatga caagcgaagc 1439581 tcctggcttt gaaggcatgt tctatgatga tgcaaacaaa gcgatcacac agcagcttga 1439641 tgaaaaaggc gcacttgtga agcttgaatt cattactcat tcttatccgc atgattggag 1439701 aacaaaaaaa ccaaccattt tcagagcaac agcgcaatgg tttgcgtcta ttaaagattt 1439761 cagatcagac ctgctggatg ccattaaaga aaccaaatgg gttcctgaat ggggcgagca 1439821 gcgtttgcac aacatggttc gggaccgcgg agactggtgt atttccagac agcgtgcgtg 1439881 gggtgtgccg attccggtat tttacgctga aaacggagaa ccggttatta cagatgaaac 1439941 cattgaacat gtttctgaat tgttcagaca gcatggatca aacatttggt ttgaaaaaga 1440001 agcaaaggat cttcttccgg aaggctttac gcatcctggc agcccgaacg gcacatttac 1440061 aaaagaacag gatatcatgg atgtttggtt tgattcaggc tcttcacatc aagcagtgct 1440121 tgaagaacgt gatgacctcg ttcgcccggc tgatctatac ctagagggat ctgaccaata 1440181 tcgcggctgg tttaactctt ctctttctac agcagtagcc gtaacaggga aagcgccgta 1440241 taaaggtgtg ctcagccatg ggttcgcact ggatggagaa ggacgtaaga tgagtaaatc 1440301 aatcggtaac gttgttgttc cggctaaagt catgaaacag cttggtgccg acatcttaag 1440361 attatgggta tcttcagtgg attatcaggc ggacgttcgc gtgtctgacg ccattctgaa 1440421 gcaggttgcg gaagtatatc gtaaaatccg caacacgttc cgtttccttc acggcaacct 1440481 tttcgatttt gatccaaaaa caaatgcggt ggctgtcgaa gatcttcgcg aagtggatca 1440541 gtatatgctg attaagctga acaagctgat tgataaagtg aaaaaagcgt atgatgagta 1440601 cgaatttgcg gttgtgtatc acagcattca taatttctgc acaatcgaat tgagctcatt 1440661 ctaccttgat tttgcaaaag atattgtcta catcgagcat gcggatcatc cggatagacg 1440721 cagcatgcag acagtattct acgaaacgct tcttgcatta gtgaagcttt cagcgcctat 1440781 ccttccacat acggcagacg aattgtggtc tcatttaaca tttgttgaag agcagagcgt 1440841 tcagttgacc gatatgccgg aaacaatcac ggttccaaac agtgaagcga ctgaagaaaa 1440901 atttgaccgc tttatggctc ttcgtgatga cgtgttaaaa gcattagaaa ctgcgcgaaa 1440961 tgaaaaaatt atcggtaaat ctttggaagc aaacctgaaa ttgtatccaa acaaagaaaa 1441021 caaggagctc ttggcttcca taaaagaaaa cctttctcag ctgtttattg tgtctgaact 1441081 gacaatcagc gaagaaaatg aagcgccgaa cgatgcgcaa agctttgcga cgggtaaaat 1441141 cgctgtcgag aaagcggaag gcgaaatgtg tgagagatct cgtgtgattt caaaagatgt 1441201 aggggcaaat ccgaaatatc ctacactttc attacgcaac gctgaaatcg ttgaaaaata 1441261 ctatcaaaaa taatgcaaaa gagcccggcg taaaagccgg gctttttttg tgccaagagt 1441321 gacatccttt agaacgaaag gaaaaatctt atgggcttta gatcatcatt cacaggcaac 1441381 aataaagata ctacgttaag agcaggagtt gtgaagaatg aatgatcaac tgaccgcaat 1441441 ttatacggaa cttcttctga tgaaagaaga attacagtcg agattatttg agtattcttg 1441501 ctttcaggtt tctacaagcc cgcaagcagc aatcaatcaa aaacaaaaag caactctgat 1441561 ctatcatatt aaagaagaac ttcaagacgt tctccttgca ttgtccaaaa tcgaaaacgg 1441621 cacattcgga tactgtgaag aaactggggc ccccattcct cttgcaaagc tggcagtgct 1441681 gccgacggcc cgaacagcaa acgattttct ttattctgtc caatttgaga aaaaaacgct 1441741 tccgatatgg aaatcaacgg atatcgaata tggtcaggca ctgtatgaat aacagtgtct 1441801 gtccggttaa tatgcctgat atttctttac tccagtgctt tttattgata aaatgcataa 1441861 tggattaaag taaccgtaaa ctggaggaac gtttgtgctg tattatatga ttgcactact 1441921 tattattgca gccgatcaat tgacaaaatg gctagttgtt aagaacatgg aacttggcca 1441981 aagcattccg atcattgatc aggtattcta tatcacctcc catcgcaata cgggtgctgc 1442041 atgggggata ttagcgggtc aaatgtggtt tttctacctc ataacaaccg ctgttattat 1442101 tggtattgtt tattacatac agcgttatac aaagggacaa aggcttcttg gcgttgccct 1442161 cggacttatg cttggcggtg ccatcggcaa ctttatcgat cgggctgtca gacaggaagt 1442221 tgtggatttt atccatgtta ttattgtcaa ttacaattac ccgatattta acatcgcgga 1442281 ctcttcacta tgtgtcggcg taatgctttt atttatacaa atgctgttgg acagcgggaa 1442341 aaagaaaaag gagcaatagc atgaatcaaa ttgatataac cgcttcagaa gaacaaaaaa 1442401 gtgagcggat tgataaattt ttggcatcga ctgagaatga ttggtcaaga acccaggttc 1442461 agcaatgggt aaaagacgga caggttgtcg tgaacggaag cgcggtgaaa gcgaattata 1442521 aaattcagcc gggtgatcag gtgaccgtca ctgtacctga accggaagcg ctcgacgtcc 1442581 tggcagagcc tatggatctg gatatttatt atgaggacca ggatgtgctg gtcgtcaaca 1442641 aacctcgcgg aatggttgtt cacccagcac ccgggcatct tacgggcaca cttgtaaacg 1442701 gtcttatggc tcattgcaca gacctttccg gaataaatgg tgtgatgcgc ccgggtattg 1442761 ttcacagaat cgataaggac acgtccggtt tattaatggt ggcgaaaaat gatatggcgc 1442821 acgagtcact cgtaaaccaa ttggtcaaca aaacggtcac gcggaaatat acggcggttg 1442881 tccacgggct tatttctcat gatgacggca caattgacgc gccgatcgga cgggataaaa 1442941 aagaccgtca aagcatgact gtgacacgtg atggcaaaaa cgctgtcact cattttcatg 1443001 tgcttgagcg ttttcaggat tttacgttag tggagtgcca gcttgaaaca gggagaaccc 1443061 atcaaattcg tgttcatatg aaatatatcg gattcccatt agcaggcgat ccgaaatacg 1443121 gcccaagaaa aacaatcgac tttaatggcc aagcgcttca cgcgggagtt ttaggttttg 1443181 accatccacg aacaggagaa tatgtcgaat ttgaagcgcc gcttcccgag gatatggcag 1443241 aattaatcga aaacctcaga aaaaacggtt gacagagggt ttcttttctg aaataataaa 1443301 cgaagctgaa tagattcttt aaaacagtcc agagaggctg agaaggataa cggatagacg 1443361 ggatgcgtgt ataggcgcgc accttgtcct aaaacccctc tatgctctgg caggaggggt 1443421 tttttcttct atatgaactg tgaggtgtca cacattgaat caaaaagctg tcattctcga 1443481 cgaacaggca attagacggg cgctgaccag gattgctcac gaaatgatcg aacgcaataa 1443541 aggaatgaat aactgcattc ttgtcggcat taagacaaga gggatttacc tggcaaaacg 1443601 ccttgcggaa cgcattgaac agattgaggg aaatcctgtt acagtcggtg aaattgatat 1443661 tactctttac agagatgatc tttctaaaaa aacaagcaac gatgaaccgc ttgtaaaagg 1443721 tgcagatatt ccggtagata ttacagatca aaaagtcatt ctcgttgatg atgttctgta 1443781 taccggaaga acagtcagag caggaatgga tgcgcttgtt gatgtaggca gaccttcctc 1443841 cattcagctt gcagtgcttg tggacagagg acaccgggag ctgccgatcc gagcggatta 1443901 tatcgggaaa aacatcccga catcaaagtc tgaaaaggtt atggtacagc ttgatgaggt 1443961 agaccaaaac gatctcgtcg ccatttatga aaacgaataa tagatcacct ttttaagggc 1444021 aatccagaga ggttgcaaag aggtgcacaa caaaggccca aaaagtattc ggcaggtctt 1444081 tgtatgcctc tttgcgtaaa aaagcaaaga ggttttttta tacagtcatt gagtcatcct 1444141 aaaatgaaag tcaacaatca gggggaaatc atcatgagta agaaaaaagt aaatttaggg 1444201 gtcagggatg tcccgacacc tttctcttgg gtttcattca gccttcagca tttgtttgcc 1444261 atgtttggct caaccatttt ggttccgaag ctcgtcggaa tgagtcctgc tgtggcgttg 1444321 gtgacaagcg gcatcggaac actggcgtac cttcttatta ccaaaggaca aattccggcg 1444381 tatctcggtt catccttcgc ctttatttct ccgatcattc tggtaaaagc gaccggcggg 1444441 ccgggagcgg caatggttgg agcgtttctt gcagggctgg tgtacgggct gattgcctta 1444501 ttgattaggc agcttggaac aggatggctg atgaagattc tcccgcctgt agtcgtaggg 1444561 cctgttatta tcgtcatcgg gctgggactg gcaagcactg cagtaaacat ggcgatgtat 1444621 gctgatccga acgcgagtga gttggtctac agcttaaagc actttagtgt cgcaggagtt 1444681 acgctggcaa ttacgattat ttgtgcgatt ttcttacgag ggtttttaag cctgattccg 1444741 gttctgatcg gaatcatcgg cggatacctg tttgccctta ctcaagggat tgtcaacttc 1444801 cagccggtgc ttgacgcgaa atggtttgca gtgcctgaat ttatcattcc gttcaaagat 1444861 tattcaccgt cagttacgct cggcatcgca gccgcaatgg ttcctgtcgc atttgtcaca 1444921 atgtcagagc atatcggcca ccaaatggtg ctgagcaagg ttgtcggaca agacttcatt 1444981 aaaaagccag gtcttcatcg ctctattatg ggtgacagtg tggcgacaat cctcgcttcc 1445041 ctgatcggcg gccctccgac aacgacttac ggagaaaaca ttggcgtgct ggccatcaca 1445101 agagtattca gcgtctttgt catcgggggc gcggcagtga ttgccctttg cttcggcttt 1445161 atcggcaaaa tttcagcgct gatcagttca gtgccgtcag cggtcatggg aggcgtctcc 1445221 ttcctgctgt tcggaatcat tgcttcaagc ggcctgagaa tgctgattga caacaaaatt 1445281 gattatgaaa acaacagaaa cctcattatt acatcagtta tccttgtcat cggtgtagga 1445341 ggcgctttta tccaagtgtc tcagggcgga ttccaagtgt caggaatggc gcttgccgca 1445401 attgtcggtg tcatcttaaa cctgattctt ccgcaggcga aggaagagca ggcagacaca 1445461 tctgaacaac atcatattta aaacctttta atgaaagtcc agagaggctt ggaagggtta 1445521 tgaagagaag gaagcttcaa tgctgccctc tatttaacca taccccgagt ctatcttaga 1445581 ccggggtttt ttttcagcct taagttgaaa agagagggga aagaacatga agcatttaac 1445641 gacgatgagt gaacttagca ctgaggaaat caaagatttg cttcaaacag cacaagagct 1445701 caaaagcgga aaaacagaca atcagcttac aggaaagttt gcagcaaacc tgtttttcga 1445761 accgagcacg agaacgcggt tcagctttga ggtcgcagaa aaaaagctgg gcatgaatgt 1445821 gcttaacctt gatggaacaa gcacaagcgt gcaaaaaggc gaaaccttat atgacacgat 1445881 ccggacgctt gaatcaatcg gtgtggacgt ctgcgtcatc aggcacagtg aggatgagta 1445941 ttatgaagag cttgtcagcc aggtgaacat tccgattctg aatgcgggag acgggtgcgg 1446001 ccagcatcca acacaatcac tgcttgattt aatgacgatt tatgaagagt tcaatacgtt 1446061 taaagggctt accgtctcca ttcacggcga catcaagcat agcagagtgg caaggtcaaa 1446121 tgcggaagtg ttgacaagat tgggtgcccg ggtcctattt tccggccctt cggaatggca 1446181 ggatgaagaa aatacattcg gcacgtatgt ctcaatggat gaagcagttg agtcttccga 1446241 tgttgtcatg ctgctgcgca ttcaaaatga acgacatcag tccgctgtca gtcaggaagg 1446301 ctatttaaac aaatacggct tgaccgtaga acgggctgag cgtatgaagc ggcatgcgat 1446361 catcatgcat cctgctccgg taaacagagg agtggagatt gatgacagct tagtagaaag 1446421 cgaaaaatca agaatcttca agcaaatgaa aaatggcgta tttatcagaa tggcagtgat 1446481 acagcgtgcc ttacaaacca atgtgaaaag aggagaagca gcgtatgtca tatctcatta 1446541 aaaacggctg gatactaaac gaaaatggtg aaaaaacaca agcggatatc cgagtgactg 1446601 gagaaaccat caccgcaatc ggcaagcttg atgcaacgga taatgaaacg gtaattgatg 1446661 caaaaggttt gctcgtttca cctgggtttg ttgatctcca cgtgcatttc agagagccgg 1446721 gcggagagaa aaaagaaact attgaaaccg gggcaaaagc agcggcgcgc ggcggctata 1446781 ctacagtagc agcaatgccg aatacgcggc cggttcctga tacaaaggag cagatggaat 1446841 gggtgcaaaa cagaattaaa gaaacatcat gcgtaagagt tcttccatat gcatccatta 1446901 cgatcagaca aatcggcgat gaaatgacaa actttgaagc gttaaaagaa gccggggcat 1446961 ttgcttttac agatgacggc gttggtatac agacagcagg aatgatgtat gaagcgatga 1447021 aacgggcagc cgcaattgac aaagcgattg ttgcacattg cgaggacaac tccttaattt 1447081 acggagggag cgtacatgag gggacattct ccaaagcgaa cgggctaaac ggcattcctt 1447141 ctgtgtgtga atcggttcat attgctcgcg atgtgctgct ggctgaggcg gcaaactgcc 1447201 attatcatgt atgccatatc agcacaaaag aatctgtcag agttgtacgc gatgcgaaaa 1447261 aagcgggaat cagagtgaca gcagaagtat cgccgcatca tttgctgctt tgtgatgagg 1447321 acatcccggg gctggacaca aactataaaa tgaatcctcc gctccgcagc ccagaagaca 1447381 gagctgcttt aattgaaggt cttttagacg gaacaattga ttttatcgca acagaccatg 1447441 caccgcatac ggaagaagag aagaacacag aaatgaagct ggcgccattc ggaattgtcg 1447501 gcttagaaac agcattcccg cttctttaca cacactttgt caaaaatggc agctggtcac 1447561 tgaagcagct gattgactac atgacaatca agccatgcga agcgttcggt ctcccatatg 1447621 gaacattaca aacggggcaa gctgcggaca ttacgttaat cgatttagaa aaagaagcag 1447681 ttatagacaa agagacattt ttatcaaaag gaaaaaatac accattcaac ggcatcagtt 1447741 gcaccggctg gccggtcgct acaattgcgg cagggaagct tgcttatgaa gaggggagac 1447801 ttgtcaaatg aagagacgat tagtactgga aaacggagcg gtattcgagg gagaagcttt 1447861 cggaagctta gaacacaaca tgggagaagt cgtttttaat actgggatga caggctatca 1447921 ggaaatttta tctgatcctt cttactgcgg acagatcgta acattaacat acccgcttat 1447981 cggaaattac ggcattaacc gtgatgattt tgaatccatt accccttttg tcaaagggct 1448041 gatcatcaaa gaattatgtg agctgccttc caactggcgt tcagcataca ccttagacga 1448101 gtatttaaaa atgaaaaaca ttcccggact ccagggaatt gatacaagga agctgacaag 1448161 aatgatccgc acggcaggcg cgctaaaagg aacattcgct tcatctgatg aagatatcga 1448221 agcagtgctg aaaagactga acgaaacgga attgccaaga aatcaagtat cccaagtatc 1448281 agcaaaaaca gcatatccga gcccgggaag aggcaaacgc attgtcttgg ttgacttcgg 1448341 catgaaacac gggattctaa gagagctgaa caaacggaaa tgtgacgtca tcgttgtgcc 1448401 ttacaacatt acagcggaag aggtgcttca gctgaaaccg gacggtatca tgctttctaa 1448461 cggacctgga gacccgaagg atgtgcctga agcgattgaa atgattaaag gtgttcttgg 1448521 aaaagtgcca ttattcggaa tatgtctcgg ccaccaatta ttcgcgctgg cgtgcggggc 1448581 gaatactgaa aaaatgaaat tcggccacag gggctcaaac cacccggtaa aagagctggc 1448641 tacaggaaaa gttgccttaa catctcaaaa ccatggatat acagtttcgt ctatcagtaa 1448701 aacagaactg gaagtgacgc atatcgcaat taacgacgat acgattgaag ggctgaagca 1448761 taaaacattg ccggcattta cggttcaata tcatcccgaa gcctcacctg gtcctgagga 1448821 tgccaaccat ctatttgaca gattcatcga aatgatcgaa acaacagaga aagaagggga 1448881 agcggtatgc caaaacgcgt agacattaac aaaattttag taatcggatc tggaccgatc 1448941 atcatcggcc aagcagcaga atttgactat gcgggaacac aagcctgtct tgctttgaaa 1449001 gaagaaggct atgaagtcat ccttgtcaac tcaaaccctg caacgatcat gacagataca 1449061 gaaatggctg accgggttta catcgaaccg ctcacacctg aattcctgac acgaatcatc 1449121 agaaaagagc gcccggatgc cattcttcct acactcggag gccaaaccgg tttgaatctt 1449181 gcggttgagc tttctgaaag aggcgttttg gcagaatgcg gcgtcgaagt gcttggcacg 1449241 aaactgtctg cgattcagca agctgaagac cgtgacttgt tcagaacatt aatgaatgaa 1449301 ctgaatgaac cggtgcctga aagtgagatt atccactccc ttgaagaagc agaaaaattc 1449361 gtcagtcaaa ttggattccc tgtcattgtc cgcccggcat atacattagg cggaacaggc 1449421 ggaggcatct gctcgaatga aacagagcta aaagaaatcg ttgagaacgg cttgaaatta 1449481 agcccggtac accaatgtct gcttgaaaaa agcatcgccg gctataaaga aatcgagtat 1449541 gaagtcatga gagacagcca ggatcacgcc attgtcgttt gtaacatgga aaacattgat 1449601 ccagttggaa tccatactgg agacagtatt gttgtcgcgc cgagccaaac gctcagcgat 1449661 cgcgaatatc agctcttgcg gaatgtatcg ttaaaactga ttcgcgcgct tgggatcgaa 1449721 ggcggatgta atgtccagct cgccttagat ccagacagct tccaatatta cattattgaa 1449781 gtaaatccgc gtgtcagccg ttcatctgcc cttgcatcaa aagcaacggg gtacccgatt 1449841 gcaaagctcg ctgctaaaat tgcagtcgga ctttcattag atgaaatgat gaacccggtg 1449901 acaggaaaaa catatgcagc atttgaacct gctcttgact atgtcgtatc caaaattccg 1449961 cgctggccgt ttgataagtt tgaatcagca aacagaaagc ttggcacgca aatgaaagcg 1450021 acaggtgagg tcatggcaat cggccgcacg cttgaagagt cattgctgaa ggcagtgcga 1450081 tcactggaag cggatgtgta tcatcttgaa ttgaaggacg ccgctgacat ttcagatgag 1450141 cttcttgaaa agcgaattaa aaaggccggt gatgaacgct tattctactt agctgaagcg 1450201 tacagaagag gctacacggt agaagacctc catgaatttt ccgctatcga tgtcttcttc 1450261 ttgcataagc tgttcggaat cgtacagttt gaaaaagaat tgaaggccaa tgcgggcgat 1450321 acagatgtgc tgagacgggc aaaagaactc ggcttctctg atcagtacat cagccgtgaa 1450381 tggaaaatga aagaatctga gctttacagc ttgagaaaac aagcggggat tgcgccggta 1450441 ttcaaaatgg tagatacatg cgcggcggaa tttgagtcag aaacgccata cttctatagc 1450501 acatatgaag aagaaaatga atctgtcgtt acagataaga aaagtgtgat ggtgcttggt 1450561 tcgggtccga ttcgaatcgg tcagggtgtc gagttcgact atgcgacggt tcactctgta 1450621 tgggcaatta aacaagcagg ctatgaagcc attattgtca acaacaaccc ggaaaccgtt 1450681 tcaacagact tcagcatctc agacaagctg tattttgaac cgcttacgat tgaagatgtc 1450741 atgcacatca ttgacctcga acagccaatg ggcgttgtcg tacaatttgg cggacaaact 1450801 gcgattaacc ttgctgacga gctttctgca cgcggagtga aaatccttgg aacttcatta 1450861 gaagatttag accgtgccga agaccgggat aaatttgaac aagcgcttgg agaacttggt 1450921 gttcctcagc cgcttggcaa aacagcgaca tcagttaatc aggcggtaag catcgcaagt 1450981 gatatcggtt atccggtact ggtacgccct tcctatgtac ttggcggccg ggcgatggag 1451041 attgtttacc atgaagagga actgcttcat tacatgaaaa atgcagtcaa aatcaatcca 1451101 cagcaccctg tattaattga tagatacttg accggaaaag aaattgaagt cgatgcagta 1451161 tccgacggtg aaacagtcgt cattccggga attatggagc acattgaacg tgcgggcgtt 1451221 cactccggag actcaatcgc tgtttatccg cctcagtctc tcacagagga cattaagaaa 1451281 aaaattgaac aatacacgat cgcattggct aaagggctga atattgtcgg tttgctcaat 1451341 attcaattcg tcttgtcgca aggcgaggtg tacgtgctag aagtgaatcc gagatcaagc 1451401 agaaccgtac cgtttttaag caaaattacg ggtatcccaa tggcgaatct cgcaacaaaa 1451461 atcattcttg gtcaaaagct ggctgcgttt ggctatacag agggccttca gcctgaacag 1451521 caaggtgtat ttgtaaaagc gccggtcttc tcctttgcca agctgagaag agtggatatt 1451581 acgttagggc ctgaaatgaa atcaacaggt gaagtcatgg ggaaagattc gacacttgaa 1451641 aaggcgctct acaaagcctt gatcgcttca ggtattcaaa tcccgaacta cggttccgtg 1451701 cttttaacag tagctgataa ggacaaagaa gaagggcttg ccattgctaa gcggttccac 1451761 gcgatcggct acaacatttt agcgacggaa ggaacggcag gctacctgaa agaagcttcc 1451821 attccagcga aggtcgtcgg aaaaatcggt caggatggcc cgaacttgct tgatgtcatc 1451881 agaaacggag aagcgcagtt tgtcatcaat acgctgacaa aaggaaagca gccggcaaga 1451941 gacggtttta gaatcagacg tgaatcagta gaaaatggtg ttgcctgcct aacatcttta 1452001 gatacggcag aggcgatatt gcgagtgctg gaaagcatga cattccgtgc tgatcaaatg 1452061 ccggcagtca acacaaatca ggaggcggca gtcactatat gaaaaaagcg tatttgacag 1452121 tatgttctaa ccagcaaatt gcagaccggg tgtttcaaat ggttctgaaa ggggagcttg 1452181 tccaagggtt tacaacccct ggacagttcc ttcatcttaa agtgagcgaa gcggttacgc 1452241 ctcttttgag aaggccgatc agcatcgcag acgtcaactt tgaaaaaaat gaagtcacca 1452301 tcatttatcg ggtagatggg gaagggacaa gactcttgtc actgaagcag cagggagaac 1452361 ttgtggatgt cctcgggcct ttgggaaatg gctttcctgt taatgaagtt caacccggaa 1452421 agacggcttt gctggtagga ggcggagtag gtgtgccgcc tctccaagag ctgtcgaaac 1452481 gcttgattga aaaaggggta aatgtcatcc acgttttagg attccaatcg gcaaaggatg 1452541 ttttttacga ggaagaatgc cggcagtacg gagacacgta tgtggcaaca gctgacggaa 1452601 gctacgggga aaccggattt gtcacagatg tgattaaacg gaaaaagcta gagtttgata 1452661 tcctcctcag ctgcgggccg acaccgatgc tcaaggcgtt aaaacaggaa tatgcccata 1452721 aagaagtata tctgtccatg gaggaacgaa tgggctgcgg aatcggcgca tgcttcgcgt 1452781 gtgtgtgcca tacaaacgaa agtgagacat cctatgtaaa agtatgtctc gacgggcctg 1452841 tatttaaagc tcaggaggtg gcgctgtaat gctagaggtg aaattgccgg gacttgattt 1452901 gaaaaaccca atcattcctg catcaggctg cttcggtttt ggaaaagaat tttcacgttt 1452961 ttatgatttg tcttgtcttg gagctatcat gattaaggct acgacaaagg agccgcgctt 1453021 tgggaatccg acgccgcggg tagctgagac tggtgctgga atgctcaatg cgatcggtct 1453081 ccaaaatccg gggctggata gtgtgttgca tcatgagctg ccgtggcttg agcagtttga 1453141 tacaccgatc attgccaatg tcgcaggttc tcaagtcgat gattatgttg aagtcgcaga 1453201 acatatcagc aaagcgccta atgttcatgc tcttgaattg aatatttcct gcccgaatgt 1453261 gaaaacaggc ggaatcgctt ttggcacgaa tcctgaaatg gctgccgatt tgacaaaagc 1453321 ggtgaaagag gtttcggatg tacccgttta tgtgaagcta tccccgaacg tggctaatat 1453381 cacagaaatt gcattagcga tcgaggaagc gggagcggac ggtcttacga tgatcaacac 1453441 actaatcggc atgagactcg atttaaaaac cggcaaaccg atattagcga ataaaacagg 1453501 gggactttcg ggccctgctg tgaagccggt tgccattcgc atggtgtatg aagtcagcca 1453561 gatggtcaac atcccgatta tcggaatggg aggcgtgcaa acggctgaag atgccctgga 1453621 atttcttctc gcgggagcaa gcgcagtcgc tgtcggaaca gcaaactttg tgaatccttt 1453681 tgcatgtcca gagattattg aacagctccc atctgttttg ctccaatacg gctatcaatc 1453741 aattgaagaa tgcatcggaa ggagctggaa tcatgaaaaa caacctgccc atcatcgcgc 1453801 ttgattttgc gtcagctgaa gaaacacttg cgttcttagc gccttttcag caagaaccgt 1453861 tatttgtaaa ggttgggatg gagctttttt atcaagaagg gccatctatc gtgaaacaac 1453921 taaaagaaag aaactgcgag ctatttttag atctaaagct tcatgacatc ccgactactg 1453981 taaacaaagc gatgaagcgc cttgccagtc ttggagtaga cctcgtcaat gttcatgctg 1454041 ccgggggcaa aaaaatgatg caggcagctc tcgaaggctt agaagaaggt acgccggctg 1454101 gaaaaaaacg tccgtcactt atcgcggtaa cccagctgac aagcacatct gaacaaatca 1454161 tgaaagatga actgctgatc gaaaagtctc tgattgatac ggttgtgcac tacagcaaac 1454221 aggcggaaga aagcggactg gatggagtgg tctgctctgt tcatgaagca aaagccattt 1454281 accaagcggt gtcgccttca tttctgactg tcactccggg gatcagaatg tcagaggacg 1454341 ctgcgaatga ccaagttcgc gtagcgacgc ctgccattgc aagagagaaa ggttcatcag 1454401 cgattgtagt aggacgctcg attacaaaag cggaagaccc ggtaaaagcc tataaggctg 1454461 tcagacttga atgggaggga atcaaatctt gaaacaaatc atcgcaaaac atctattaga 1454521 catccaagct gtatttttac gcccgaacga gccgttcaca tgggcaagcg gcattttatc 1454581 accgatctac tgtgacaacc gccttacgct atctttccca gaggtcagaa acgatgttgc 1454641 ttcaggtatc agcaagcttg ttaaagagca ttttcctgaa gctgaaatga ttgcgggaac 1454701 agcaactgcc ggtattcctc atgctgctct tgcggcggac catttgaatc ttccgatgtg 1454761 ttatgtgagg agcaagccga aggcgcacgg aaaaggcaat cagattgagg gagctgtgca 1454821 agaagggcaa aaaacagtcg tcattgaaga cttaatttcc acaggaggca gcgtgcttga 1454881 agcttgtgca gctttacaag cggccggctg tgaagtgctt ggtgtcgtct caatctttac 1454941 gtacggactt cctaaagcgg aggaagcctt cgcaaaggca gaactgccat actactcatt 1455001 aaccgattat gatacgctca cagaggtcgc gcttgaaaac ggaaatattc attcagatga 1455061 tctaaaaaag ctgcaaacat ggaaacgaaa tcccgagtca aaagattggt ttaaaaaata 1455121 aaaaataaat tcaaatgatg taaagaggct tcaaagcctt gctgtacttg aaaacaggct 1455181 gtgaggcctg tttttttatt aatcctataa aaaaagtcgg gttgacttat gttagaattg 1455241 tgctaaaatt tactacaaat ctaaaaactt atcaagagcg gctgagggac tggacctatg 1455301 aagcccggca acctgcatag tttgtaaggt gctacttcca gcaaaatgaa ttccattttg 1455361 aaagataagg gctgcatgct gttcctgtct ttctttccgc cggattgaaa gttttttatt 1455421 ttaagaggta aaaaggctat ctgtatatca gcagccgcga atcacattac atgggaaaag 1455481 acaaccggca gaaagctact gtttgtttgt ctccgaaagg aggaaagaag aaatgttaac 1455541 gtatgataat tgggaagaac caacgattac atttccggaa gacgatcctt ataaaggagc 1455601 gctgtcagtt ttaaaatggg catacggcca ttacggcgat cagcttgttt atgcctgcag 1455661 tttcggaatt gagggaatcg ttctgattga cttaatttat aaagtgaaaa aagacgcaga 1455721 gattgtgttt cttgatacag gacttcattt taaagaaacc tatgaaacaa ttgaacgagt 1455781 gaaagagcgt tatccgggtc ttaatatcat cctgaaaaaa ccagatctca cccttgagga 1455841 acaagccgaa gaacatggtg acaaactatg ggaaagagag ccgaatcagt gctgctatct 1455901 tagaaaggtc gttcctttaa gagaggcgct ttcaggacat ccagcctggc tttccggcct 1455961 gcgccgtgat caagggccaa gccgtgccaa tacgaatttc ttaaacaaag atgaaaaatt 1456021 caagtcagta aaagtttgcc cgcttatcca ttggacttgg aaagacattt ggagatatac 1456081 atcccggaat gaactggact acaatccgct tcatgaccaa ggctatccaa gtattggctg 1456141 tgcgccttgc acttctcccg cttttacagc agaagatttg cgctcaggca gatggaatgg 1456201 tatggcgaaa acagaatgcg gactgcatga ataaggagct gcaaaatgga attagccgct 1456261 attttattta gcttgttttt cgcgatgaat attggtgcaa gcggcgctgc agcttcgatg 1456321 ggggttgctt acggctccgg agccatcaaa aagaaaactt acgctttgat cctatgcgca 1456381 gtcggtgtct ttgccggggc ggtcattggc ggaggcgagg ttgtaaaaac aatcagctcc 1456441 ggcattattc ctgagcagac gattacactg acgattgttt gcatcattat tggagctgct 1456501 gccctgtcgc tctttactgc taatctgctc ggcattcctt tgtcgacaag tgaagtaaca 1456561 gtcggcgcgg ttgtcggcgt gggagtggct tataaagtat tgtttgtgaa caatcttctg 1456621 atcattgtgt cattttgggt ttttgtcccg ctgttcgctt tcggcttcac ctatttcgta 1456681 tctaagctgt ttcgttattt taagattgaa gtaaaatctt ctaaaaagca aaaaatcctc 1456741 ggcattgttt tgttagttgc cggatttttc gaagcattct ctgccggcat gaataacgtg 1456801 gcgaatgctg ttggcccgtt agtagctgcc ggtgtgcttg atgtcggaaa aggaaccttg 1456861 tatggaggag cttttgttgc tcttggcgca ctgttattag gccggcgagt gctagaaaca 1456921 aacgggaaga aaattacgag gttctccaaa ggggaaggca ttctcttatc cggtacagga 1456981 gcgggactgg tgatcatcag ttctgtattt gggatgccgg tgcccttggc gcaagtcacg 1457041 tcatcgtcta ttatcggaat aggcatggcg aaaaacggtc cgaacgtgtt ccataaacaa 1457101 gttgttcaaa cgatgctgaa ggtatggatc gtatcgccgt ttttatcttt atcgatttct 1457161 tatctgcttg tatccttgtt tttaaaagca gattattatt cgatctttat catggtaagt 1457221 gtgcttttag cggcgggcgg tgccatcagc ctgacaaagg ccattcgtaa agagagacgc 1457281 tcagtccacg aacaaggcgg gggaatctga tcattaatct gagtaatttt ataagttaac 1457341 taggaggaga tggatattat gagcttagca ccacacggag gaacattagt aaacagagta 1457401 gatgaatcat atgatgtgag cggcattcaa aaagaaattg aacttgattt aatttctttc 1457461 gcggatttgg aattgatcgg tatcggtgca tacagcccga ttgaaggttt ctttaatgaa 1457521 aaagattacg tatcagtggt cgaaaacatg cgtctttctt ccggcgttgt ctggtctctt 1457581 ccaatcacgc ttccggtcga tgcgcaaaaa gcagcggaac tgtcacttgg tgaaacggta 1457641 aagttaacgt atgaaggaga aacttacggc gttatccaaa tcgaagacct gtacgtgcct 1457701 gacaaacaaa aagaagctgt caatgtgtac aaaacagatg aacaggagca tcctggtgtt 1457761 aaaaagctgt tcagccgcgg caatacatat gtcggcggac cgattacgtt gattaaaaaa 1457821 gcttcaaaac agttccctga atttacattt gaaccgtcag aaacgagacg ccagtttgcg 1457881 gaaaaaggct gggaaaccat tgtcggtttc caaacaagaa accctgttca cagagcgcat 1457941 gaatacattc aaaaaacggc tcttgaaaca gtagacggct tgttcttgaa tccgttagta 1458001 ggtgaaacaa aatctgatga cattccagct gatgtacgga tggaaagcta ccaagtgctt 1458061 cttgatcatt attacccgaa agatcgtgtt ttccttggtg tctttttagc ggcgatgcgt 1458121 tatgcaggcc cgagagaagc aattttccac gcgcttgtca gaaagaacta cggctgcaca 1458181 catttcatcg tcggccgtga tcatgcaggt gtaggcgact attacggaac atacgaagca 1458241 caggaactgt ttgacacatt taaacctgaa gaactcggaa ttacaccgct gaaatttgag 1458301 cacagcttct tctgtaaaaa atgcggaaat atgggaacag caaaaacttg ccctcatggc 1458361 agagagcatc acgtcatttt atcaggcact aaggtaagag gtatgctgag agacggtgtg 1458421 ctgccgcctg ctgaattcag tcgaaaagaa gtagtagaag tgttaatcaa agggatgaag 1458481 aaaaaagaag aagtaggcgt atcttaagga ggactggcag tgacaaatcg cgatattgta 1458541 tggcatgaag cctctatcac aaaagaagag tatcagcaaa aaaacaagca taaaagctcc 1458601 attctctggc tgacagggtt aagcggctca ggcaaatcaa ccattgccaa cgccgctgcg 1458661 agagaattgt ttgagcaagg ctaccaagtc attgtgctgg acggggataa tatccgtcac 1458721 ggcctaaata gggatcttgg tttttctgat gaagaccgaa aagaaaacat ccgccggatc 1458781 ggagaggtgg cgaagctttt tgttcagcag ggaaccattg tgattactgc ttttatctct 1458841 cctttccgcg aggacagaca acaggttcgc gagcttgtgg aagcgggcga atttaatgaa 1458901 gtctacatta aatgcgacct tgatatttgt gaacaaagag atccgaaagg gctttacaaa 1458961 aaagcaagaa acggcgagat tccgttcttt acaggaattg attctcctta tgaagaaccg 1459021 gaagctccag agctcgttct tgattcagga cagcatgacc gtgaagcgtg taaaaatcag 1459081 ctgatcgagt ttgttaaaca aaaattgagc tgaatatgat ctgctgcgtt cttctcagat 1459141 gccggaatgc aagcgagaac atcatcacag cgaatcttct ggaagaactc gaatagatcg 1459201 ggggaaatac gatggggaaa gtatatattg taggagcggg tcccggtgac cctgatctgc 1459261 tgacaattaa agcgctgaaa gccattgaaa aagctgatgt catcttatat gacagattag 1459321 taaataaaga gattttacaa tatgccaaag agcaagcaga cctgatctac tgcgggaagc 1459381 ttccggattt tcatacgatg aagcaggaaa ccatcaatcg atttcttgtg aagtatgcgc 1459441 aaaaagggaa aatggttgtc agactgaaag gcggagaccc ttttgtgttc gggagaggag 1459501 gggaagaagc ggaatgcctc tctgaaaatg gaattccgtt tgaaatcatt cccggcatta 1459561 cgtctggaat cgcggcagcc gcttatgccg ggattcctgt tacccatcgg gatgcgggct 1459621 ctaacgtcgc ttttgtaacg ggtcactata aaaaagaaga agattttgag gaaaagtgga 1459681 aagcgctggc tacaggaatt gatacacttg tcatctatat gggtatcaaa aacgtgcagc 1459741 agattgaaag aaaactcctt gaaaatggcc gggacggttc tacgccagca gcctttattc 1459801 attgggggac aacggacaag caaaaatctg ttttttgtac agttgacacc ctttcagaaa 1459861 cggtgataaa agaaaacatt acaaatccga gtttaattgt cattggaaat gttgtaaatt 1459921 atcactataa gctggaatgg tttgaatctg aactaaaaaa acaagattta agcgaggcgt 1459981 tgtaaaaatg aaacaagcaa ttttatatgt cggccacggc agccgggtca aaaaagcgca 1460041 gcaagaagcc gcagcctttt tggaaggatg caaggcccac atctctgtgc cagtacaaga 1460101 aatcagcttt ttagagcttc aggagccgac aattgagaca ggatttgaag catgtgtgaa 1460161 gcaaggtgcc actcatatcg cagtggtgcc tctgcttctt ttaacagctg cgcatgcaaa 1460221 acatgatatt ccggaagaaa ttgtccgtgt tgcatctcga tatccatcag tccgtatttc 1460281 atacggaaag ccgatcggga ttgacgaaga agtagtcaag gctgtatatc accgaatgaa 1460341 agacataggt gttccgtatg aaaatgccag agtggtgctc atcggaaggg gaagttcaga 1460401 tccagacgtc aaaagagacg taaccggaat tgctaatctt cttcaggaaa tggttccagt 1460461 gaaggaagtc attccgtgct ttttgacagc atgcggccct aattacaaag aggttttttc 1460521 agaacttgaa aaagatgacg gcataacaac ctttatcgtt ccatatttgc tttttacggg 1460581 tatgctgatg aatgaaatcg aacgagaggt tcagaaatta aaagcccata atccgaacgt 1460641 ctacctctct tcctatatcg gttttcatcc tcatgtgaaa aacgcatttt tgaaccgtgt 1460701 gagagaaact gcggcaaatt ctgagggaca atttgatttt gatggaggtt catatgcttc 1460761 cgctgcacat tagcctggaa aagaagaagg ttgtgattgc ggggggcgga agcatcgctc 1460821 tcagaaggct gaaaacggtg atttctgagg gagctgatat aacgcttgtc agtccggatg 1460881 tggaaccgga aatcaagcaa atggcagaag agcggcgtat caaatgggaa aaacggacaa 1460941 ttgaaaaaga agattatctc aatgctttct tcattattgc tgcgacggat aatgcggcag 1461001 tgaacaaaga aattgcccaa tccgcttcgc cttttcagct tgtcaattgt gtcagtgacg 1461061 ctgagcttgg caatgtatat atgccgaaaa tcgtaaaaag agggcatgtc actgtgtctg 1461121 tttctacaag cggagccagt ccaaagcaca cgaaagagct tgctgaaaac gtggataagc 1461181 tgattgacgg cgattttgtt gctgaagtga acaggcttta tcagatgaga agaaagaaat 1461241 aagccagagc atacaaatgc tctggctttt ctttatgcgg ctcagctttt tttgagcttg 1461301 atgacagtat cagcatcagg cgtgacaaag acggtatgct ggctgtcata agtgacgaaa 1461361 ccgggtttcg cgccgtttgg ttttttgaca tgcctgattt ttgtataatc tacaggcact 1461421 gaacttgaat ctttagcttt tgaaaaataa gctgcaattg tcgcggcttc catgattgtt 1461481 tgctcatcag gttcgctgct tctgatcaca acgtgggagc cgggaatgtc cttcgtgtga 1461541 agccagatat cgtctctggc cgccactctt gtcgttaaat attcattttg acgattgttc 1461601 ttacccacta aaattgtcag ccctgaggtg gattcatatg tttctaacac cggattgtgc 1461661 ggtttttgct ttttctggcc tttttgctgc ttagggcgta aatatttgcc ctcaacaagc 1461721 tcttccctga tttcgctgat atcccgggga gaagcggacg aaagctgctg aatcagctga 1461781 tcaaaatatt cgatctcttc ctgtgccagc ctgatttgct cctcgacaac tgcgaccgaa 1461841 tttttcgctt tctgatactt cgtgaaatag gcctgtgcgt tttcagaagg cgttttgttc 1461901 gggtttaaag gaatcgtgat tgtcgggctt tcttcatcat aataattgat gacctcagcc 1461961 tgtttatcac cttttttcag catatataaa ttagcggtta aaagctctcc gtaaagctga 1462021 aattccttcg cgttttccga atactccagg gttttctcta attttttgat tttgttggca 1462081 ttcttcttcc gttcgttcac aacaaaacgc tcaagatcct gagcctgttg cttaacccgg 1462141 tctcgttcag cttttccgaa ataaaaacgg tcgagcagtt cgcttaatga atcaaaacgg 1462201 cgcgcttcgc cctttagatg agtcagctcc agcagataaa aatattcctt tccgtttaca 1462261 gtcgtaatgt tgggaatgaa acggtgctct ttcacttcgg caaacagtgc cagcaacgct 1462321 tttggcagtg tgactttgtt ggcaaggcct gctctgtgaa ccgcttcttt ggcgaaaagc 1462381 ggagacacgc ctgaaaagtg gtcgacaatt tgtttatcaa gccttccttc ttgaaagctg 1462441 aggtgacgca aaatatcatc ttctgacgcc tcaagaggcg atattttgtc ctgagcaggc 1462501 ggaagcttat aatcttggcc gggcagtact gtacggtagc tgttcattga cggtgataaa 1462561 tgcttaagtc cgtcgataat cacattttct gctgcgtcag tcaaaatgat attgctgtgg 1462621 cggcccataa tttctacata aagctttcgt acggtttcat cgccaatttc gtttcggctt 1462681 ttgatatgaa aaatcataat gcggtctaag cccgcttgtt caattttctc aatgaatccg 1462741 ccttcgatat gctttctcag caacatgcaa aacattggcg gttcgcttgg attttcataa 1462801 gcttgtgccg tgatatgcac ccgtgaatag ctcggatgtg ccgataataa tagtttttgg 1462861 ttttttccct tggcacggat gtggaaaatc acatcgtgct tatatggctg atggattttt 1462921 gtaattcgtc cgcccattat tttctcgtta agttcgtgtg tcattccgta tgtaaacatg 1462981 ccatcaaacg acatatgcaa tacaccctct cattcttcct gcattcgata attatagcat 1463041 gaaatgggac gagtcagaat aagcatgctt atagagtgat atctctataa gagagcaggg 1463101 gagtggacga gcggaatgaa gtttcatgaa atgggacaaa cagatttact agaggcaacc 1463161 aatacgtcca tgaaacaagg attaacagaa aaagaggtaa aaaaacgcct tgacaagcat 1463221 ggaccaaacg agctgcaaga agggaaaaaa acttcagcgc ttctcttgtt tttcgcgcag 1463281 ttcaaagatt ttatggtgct tgtgcttctg gcggcaacgt taatctcagg atttcttggt 1463341 gaatatgtag atgcggttgc gattattgcg attgtgtttg tgaatggcat actcggtttc 1463401 tttcaagaaa ggcgtgctga gcaatctctt caggctttaa aagagctttc aacaccgcac 1463461 gtcatggcac tcagggaagg aagctggaca aagattcctt ctaaggaact ggtgccgggt 1463521 gatattgtga aatttacgag cggggacaga attggcgcag acgttcgaat tgttgaagcg 1463581 agaagccttg aaatagaaga atcagcgcta accggggaat caatcccggt tgtgaagcat 1463641 gctgataaat tgaaaaaacc ggatgtttca ctcggcgata ttaccaatat ggcatttatg 1463701 ggtacgattg tgacccgcgg cagcggtgtc ggggttgtcg tcgggacagg aatgaatacg 1463761 gctatgggga aaattgccga catgcttgaa tcggcaggga cattgtcaac cccgctgcaa 1463821 agaagactgg agcagctcgg gaagattttg attgttgttg cattgcttct gaccgtactt 1463881 gtcgttgctg tcggtgttat tcagggtcat gatctgtaca gtatgttttt agcaggtgtc 1463941 tcgttagcgg tagccgctat tccggagggg ctgccggcga ttgtgacagt ggcgctttcg 1464001 cttggtgtac agaggatgat taaacaaaaa tccattgtta gaaagcttcc tgctgttgaa 1464061 acgcttgggt gtgcgtctat catttgctca gataaaacag ggacaatgac ccaaaacaaa 1464121 atgacagtga cgcatgtctg gtccggaggg aaaacatgga gagtggcagg ggccggctat 1464181 gaaccgaaag gaagcttcac actaaacgaa aaagagatca gtgtcaatga acataagccg 1464241 cttcagcaga tgcttctgtt cggagcgctt tgtaacaact ccaatattga gaaaagagac 1464301 ggcgaatatg tgcttgacgg agatccgaca gagggagcgc tgctcaccgc ggcaagaaaa 1464361 ggcggttttt caaaggagtt tgttgaatct aattacagag tgattgaaga atttccgttt 1464421 gattccgcac ggaaaatgat gactgtcatc gtagagaatc aagacagaaa gcgctatatc 1464481 attacaaaag gtgcgccgga tgtactcatg cagcgatctt cccgtattta ttatgatggc 1464541 tcagcggctc ttttttcaaa tgaaagaaaa gcagaaacag aggcggtatt aagacatttg 1464601 gcatcacagg cgctcagaac gatagcggtc gcctacaggc cgataaaagc aggcgaaaca 1464661 ccgtcaatgg agcaggcgga aaaagatctg accatgcttg gcctttcagg tatcattgat 1464721 cccccgcggc cggaagtcag acaggcgatt aaagaatgcc gtgaagcggg aattaagacc 1464781 gtcatgatta caggtgatca tgtagaaacc gctaaagcga tagcgaaaga cttgcgcctc 1464841 cttccgaaaa gcggcaaaat catggacggc aagatgctga atgaactttc tcaagaagag 1464901 ctttctcatg tggtggagga tgtgtatgta tttgcccgcg tttcccctga acataaacta 1464961 aaaatcgtaa aagcctatca ggagaacggg catattgtgg cgatgacggg agacggcgtc 1465021 aatgatgctc ctgccattaa acaggctgat atcggcgtct ctatgggcat taccgggaca 1465081 gatgtggcca aagaagcatc atctcttgtt ctcgtggatg ataattttgc gacgattaaa 1465141 tcagcgataa aagaaggcag gaacatctac gaaaatatca ggaagtttat cagatacctg 1465201 ttggcgtcta acgtcggaga aatccttgtc atgctgtttg cgatgctgct tgcccttcct 1465261 ttaccgctgg ttccgattca gattttgtgg gtcaacttgg tgacggacgg attgccggca 1465321 atggcgctcg gcatggatca gccggaagga gacgtcatga agcgcaagcc ccgtcatccg 1465381 aaagaagggg tatttgcccg caagctagga tggaaggtcg tttccagagg atttttaatc 1465441 ggagttgcca ctattttagc gtttatcatt gtgtaccacc gcaatccgga aaacttggct 1465501 tatgcccaga cgatcgcgtt tgccacattg gtgctcgctc agcttattca cgtgtttgac 1465561 tgccgcagcg aaacttctgt tttctctaga aatccgtttc aaaacctgta tttaatcggc 1465621 gcggtattgt catccatttt gctgatgctt gtagtaatct actatccgcc gcttcagccg 1465681 attttccata ctgtagccat cacgccgggg gactggatgc tcgtcatcgg tatgtccgcc 1465741 atccctactt ttttgctggc ggggtcactt ttaacaagaa aaaaataaat tcatatgata 1465801 taatcttagg ggtaatagcg tgtctattgc ccttttatta tgagaacagg gaagaattgg 1465861 gtgttttaaa atgatacgaa gtatgacagg cttcggcagt gcaagcaaaa cacaagacga 1465921 tctctctgta agcgttgaac ttaaatctgt gaactacaga tttaaagaag tgaacgctcg 1465981 tttgccaagg cctttgctat attttgaaga taagctgaaa cagaccattc tgcagcatat 1466041 tcagcgcgga agaattgagc ttttcgtatc cgttgacagc gatatgcttg ttgagaaaag 1466101 gcttgaaatt gattggccgc tgctcgatga gtttgtcgca gccgcgagag atatgaagaa 1466161 gcggtatcaa ttgtctgcag agcccgatgt aatggatttc tttaagcttg atcatgtcgt 1466221 ccaggttcat gaagaacaga cgcaaaatga caagctggag gcgttgatca tcgatgctgc 1466281 agaagaagcg gtaaaaggtc tctgtgaaat gcgtgaaaaa gaggggctgc tcttagcgaa 1466341 agactgcctg atgcatattg atcagcttga agagctggtg agagaaactg aattgctggc 1466401 tgcagatgtc gtatctcgtt accgggaacg gctgtatgcc agaatcaaag aatggactga 1466461 agacgtatta gacgagagcc ggcttgtaac agaatgcgct atttttgcag accgctctga 1466521 tatcactgaa gagattacaa ggctgaagag ccacttcgcc cagtttcgtg atatattagc 1466581 tagtggcgga gctgtcgggc gcaaactcga ctttcttgtt caggagctca atcgggaagc 1466641 aaatacgatc ggctcaaaag caaatgatca tcagatcaca aagcttgtcg ttgaaatgaa 1466701 aagttctatt gaaaaaataa aagaacaagt gcaaaatata gaatagtgac tgtgcgtatt 1466761 gtttacagac ggtcttacta ggctaaacta gagacgtcta ttttacaggg ggaacgtaga 1466821 agatgacgat taaactgatt aatatcggat ttggcaatat catctccgcc aatcggatga 1466881 tttcgattgt cagcccggag tctgcgccaa tcaaacggat gattcaggat gcaagagacc 1466941 gcggaatgct aattgacgct acatacggac gaagaacccg tgcagttgtc gtcatggata 1467001 gtgatcacat tatcttatct gccgtccagc ctgagacagt tgcacacaga ctttctgtta 1467061 aagaagaaat tatggatgaa gggcaggggt aattgccgca tgaaagaaag agggttatta 1467121 atcgttctct caggtccctc aggagttggt aaaggaacgg ttcgacaagc gatcttttcg 1467181 caggaagaca caaaatttga atattcgatt tcagtaacca caagaagtcc aagagagggc 1467241 gaagtgaacg gagtcgatta ttttttcaaa acaagagacg aattcgagca aatgattgcg 1467301 gacaacaagc tgcttgaatg ggcagagtat gtcggcaatt attacggcac gccagtcgat 1467361 tatgttgaac agacgcttca agatggaaaa gacgtctttt tagaaattga agttcaaggg 1467421 gctcttcaag tgagaaatgc tttcccggaa ggcctgttta ttttccttgc gcctccaagc 1467481 ctttctgaac tgaaaaacag aatcgtgaca cgaggaacag aaacagacgc tctgattgaa 1467541 aatcgaatga aagccgcaaa agctgagatc gaaatgatgg atgcttatga ctatgtcgtt 1467601 gaaaacgata atgtcgaaac ggcttgcgat aaaatcaaag caatcgttct tgctgaacat 1467661 ttgaagcgtg aacgcgttgc accaagatat aagaaaatgc tggaggttga ataatcaatg 1467721 ttagatccgt caattgattc tttaatgaat aaattagatt caaaatatac gctggtgact 1467781 gtttctgcga gacgtgcccg tgaaatgcaa atcaaaaaag accaaatgat tgaacatacg 1467841 atttcacaca aatatgtagg caaagcttta gaagaaattg atgcaggcct gctttcgttt 1467901 gaaaaggaag accgcgaata gtagcacaag tagcaaccta tatcatgtag gttgttattt 1467961 ttttccgtgc ggttttgtaa agtgcagagg gggagaattc attgcttaac aatcgaaatg 1468021 tgttactttg cgtgagtgga ggcatcgctg tttataaagc ctgtgcgtta acgagcaagc 1468081 tggttcaggc aggagcaaat gtcaaagtga ttatgactga atccgcttgc cgattcgttt 1468141 caccgctgac atttcaggca ttgagccgcc acgaagtcta tacagataca tttaaagaac 1468201 aaaatccaag cgtcatttct catattgatg ccgcagactg ggccgacttg attatcgtag 1468261 cgccggctac ggctaatgtg attggaaaac tggcaaacgg catcgctgat gatatgctga 1468321 cgacaacatt gttggcagca acggctcccg tttggatcgc gccggcaatg aacgttcata 1468381 tgtatgacca cccggcagtc aaacgaaaca tttctgttct ttatcaggac ggttattgtt 1468441 ttattgagcc aagtgagggc tatttagcat gcggttacgt aggaaaaggc agattggaag 1468501 agccggaaaa catcgtaaag ctggccgaaa aacattttgc tgaagaaaca tccgctcctt 1468561 tagaaggcaa gcatgtggtc attacagccg gcccaacgcg ggaagcgatt gatcctgtcc 1468621 ggttttttac caataaatcg acgggcaaaa tgggctacgc actggcggag gctgctgttc 1468681 agctcggcgc acgggtaatc ttaatttctg ggcctgtttc acttgatcag cctaaaggcc 1468741 ttgctgagtt tatccctgtt caatcggctg cggatatgcg cgaagctgtg ctctctgtgt 1468801 atgacgcaag cgatatagtc attaaaacag ctgcggtagc cgattttacg ccgaaaacag 1468861 tatttgacca taaaatgaaa aaacaagacg gcggcatgac cttagaactg aaaagaacag 1468921 tcgatatttt gaaagaattg ggcgagaaaa agaaagagca gattttggtc ggatttgccg 1468981 ccgaaacaca agacattgaa cactatgcac gtaaaaagct cgccgctaaa aaccttgatt 1469041 tgattgtggc aaatgatgtg aaagcaaatg gggccggttt tggtgctgat acgaatatcg 1469101 tgacaatctt tttcaaagac gggcataaac gcgaactccc gattatgtct aagctcgatg 1469161 tttcttttga aatccttcag gagatcgcag ccctctcaaa acaaaccgga gagcgctcat 1469221 gaattttgca gaagtcatcg ttgatgtcag caccaaaaat atagacaggc cttttgatta 1469281 taaaatccca gaccatctga agggcatgat caaaacgggg atgcgggtca ttgttccgtt 1469341 tggcccccgt aagattcaag ggtttgtgac agcagtcaaa gaagcatctg acctatcggg 1469401 aaaatctgtc aaggaagtag aggatttatt agatcttaca cctgttctga cagaggagct 1469461 tatgattctg tcatcatggc tgtcagacaa aacgctgtct tttaaaataa cggcgcttca 1469521 agcaatgctg cctgccgcct taaaggcgaa atatgaaaaa gaattaaaaa ttgcacacgg 1469581 agccgatctt ccgccgcaag tggaacggct gttttctgaa acaaagacgc tgctgtattc 1469641 agatataccc gatcatgaga cgctgaaact gattcaaagg catgttcaaa aaggggacat 1469701 tgacgtgacg tataaagtcg cgcaaaaaac caataaaaaa atggtcaggc atattcaggc 1469761 aaatgcgagt aaagaagagc ttgctaagca ggctgaggga ttgtcccgcc aagcagcaaa 1469821 acagcaggcg attcttcact ttctcatctc tgagccggaa ggtgtgaaaa ttcctgcggc 1469881 ggaattgtgc aaaaaaacgg acacgagctc tgcaaccatc aaaaccctta tccaaaaagg 1469941 gcttttgaag gaaagctatg aagaggttta cagagatccc tatcaggaca aaatgttcaa 1470001 aaaaacagag cccctgccgc tgacagacga acagagggct gccttcgagc ccatacgcga 1470061 gacattggac agcgatgagc ataaagtgtt cctccttcac ggcgtgacag gaagcggaaa 1470121 aaccgaaatt tatctgcaat caattgaaaa agtactggcg aaaggaaaag aagccatcgt 1470181 cctcgtaccg gaaatatcgc tgacgccgca aatggtcaac cgcttcaagg gccgcttcgg 1470241 ctcccaggtg gcagtcatgc acagcggttt atccacagga gaaaaatatg acgagtggcg 1470301 taaaatccac cggaaggaag tacggcttgt cgtcggtgcc agatccgcca tttttgctcc 1470361 gtttgaaaat ctcggaatga taatcatcga tgaagagcac gagtcttcct ataaacagga 1470421 agaaatgccg cgctatcatg cgaaagaggt ggcaatcaag cgggctgagc atcacagctg 1470481 cccggttgta ttagggagtg ctacgccgac attagaatca tatgctagag cgcaaaaggg 1470541 cgtatacgag cttctttcac tgaagcaccg tgttaaccat cgggtgatgc ccgaggtttc 1470601 gcttgtcgat atgagagagg agcttagaaa cggcaatcgc tcgatgtttt cagttgaatt 1470661 gatggaaaag cttgaagaaa cgattgccaa gggtgagcag gcggtgctgt ttttaaataa 1470721 gaggggctac tcttcctttg tgatgtgcag ggattgcggc tatgtcccgc aatgcccgca 1470781 ctgcgacatt tccatgacgt atcatcgtta cggccaaagg ctgaaatgcc attattgcgg 1470841 acatgaagag cctgttccgc acacttgtcc tgaatgcgca agcgagcata tccgcttttt 1470901 cggaacggga acacagcgag tggaggaaga gctgacaaaa gtgctgccaa gtgcgagagt 1470961 gattcggatg gatgttgaca cgacatcacg gaaaggcgcc catgaaaaat tactgtcagc 1471021 tttcggagaa ggaaaagcgg atattcttct cggaacgcaa atgatcgcga aagggcttga 1471081 ttttccgaat gtcacgcttg tcggagtgtt aagtgctgat acaacacttc atattcctga 1471141 tttcagatcg gctgaaaaaa catttcagct gttaacgcaa gtcagcggcc gggcaggcag 1471201 gcatgaaaag cccggccatg tcatcattca aacgtataca ccgtctcatt acagtatcca 1471261 gctgacgaaa acacacgatt atgaaacgtt ctatcagcat gaaatggcgc acaggagaga 1471321 gcaatcctat ccgccatact actatttggc tcttgtgact gtttctcatg aggaagtggc 1471381 gaaagcagcg gttacagctg aaaaaatcgc tcattttttg aaagcaaact gcggagctga 1471441 cacgaaaatt ctcggaccaa gcgcgtcgcc gatagccagg atcaaagata gatatcgcta 1471501 tcaatgcgtg ataaaataca aacaggaaac ccagttatcc gctttattga agaagatact 1471561 ggaacattat aaacgcgaaa ttgaacaaaa acatgtaatg atttcaattg atatgaatcc 1471621 ttatatgatg atgtaagatc tcacgtcttg gagggtaaca aattggcagt aaaaaaggtc 1471681 gtcacacatc ctgcggaggt tttggaaaca cctgcggaaa ccgtgactgt ttttgataaa 1471741 aagctaaaaa aactgcttga tgatatgtac gacaccatgc ttgaaatgga tggtgtcgga 1471801 ctggcagcgc cgcaaatcgg cattttaaaa agagcggccg tcgtagaaat cggggatgac 1471861 agagggagaa ttgatctcgt taatcctgaa attttagaaa aaagcggcga gcaaaccgga 1471921 attgaaggat gcttgagctt tcctaacgtc tatggtgatg tcacacgtgc cgattatgtc 1471981 aaagtgcgtg cgtttaaccg tcagggaaaa ccgttcattc tggaagcgcg aggcttttta 1472041 gcaagagccg tgcagcatga aatggaccac ttagacggtg tgctgtttac atctaaaata 1472101 agtaaatact atacagaaga tgaactagcg gatatggaag gatgatttga tgacgagaat 1472161 cgtatttatg ggaacgccgg atttttcagt tcctgtttta agaaccctga tagaggacgg 1472221 atatgaagta gtgggggtcg tcacacagcc ggaccgtccg aagggcagaa aaaaagtact 1472281 gacacctcct ccggtaaagg aagaggcatt gcgccacggc atcccggttc ttcagccgga 1472341 aaaagtcaga ttgacagaag aaattgaaaa agtgctggca ttaaagcctg acctgattgt 1472401 aacggcggca ttcggacaaa ttttgcctaa agagcttctc gacagtccaa aatacggctg 1472461 cattaacgtt cacgcatccc ttttgccgga actgcgcggc ggtgctccga tccattattc 1472521 cattctgcag ggaaagaaga aaaccgggat taccattatg tatatggtag aaaaattgga 1472581 tgcgggcgat atgatctcaa aagtggaagt ggacattgaa gaaaccgaca atgtcggaac 1472641 actgcacgat aaattaagcg ttgctggcgc gaagctattg tctgaaacgg ttccaaacgt 1472701 tattgccggc agcatatcac ctgaaaagca ggatgaagag aaagcgacgt acgcgcctaa 1472761 cattaaaaga gagcaagagc tgctcgactg gtccagaacg ggcgaagagc tttacaacca 1472821 gatccgcggc ttaaatccat ggcctgttgc ttatacgact ctaaacggac aaaacttgaa 1472881 aatatgggcg tcgaaaaaaa tagcggcacc aacaacagct gagcccggca cagtcgttgc 1472941 agttgaaaag gaaggaatta tcgttgccac aggtaacgag acggctctgt tattaaccga 1473001 actccagccg gcaggcaaaa aacgaatgaa aggcgaagac tttgtgcgag gcgctcatgt 1473061 tgaagccggt gatgtgttag gagtaaacaa tgaaaaaaac tagtgttcgt gacatcgccc 1473121 ttgaggcgct gatcaaatta gaacaaaacc aggcatacag caacctgctg ctgaaatcgg 1473181 tcattaaatc aaatgaactg agtgatcaga acagagggct tttgactgaa cttgtctatg 1473241 gtacattaca aaataagatc gcgcttgatt atatgcttaa accgtttatc aataagcctc 1473301 aaaaggtaaa gccgtgggtg attcagcttc ttcgcctatc cttatatcaa atggagtatt 1473361 tggagaagat tccagacagg gcagccattc atgaagcggt tgagattgct aaaatccgcg 1473421 gacacaaagg cattgcttca tttgtcaacg gcgtgctccg ttctattcag cgcgaaggtg 1473481 ttccatcctt tgacgcgatc gaagatcctg tccgccggct ggcgacagaa acaagccatc 1473541 cggaatggct tgtgaaagag tgggcggatg cgtatggatt tgaagctgcg gaaaagattt 1473601 gccgcatcca tctcattccg ccgaaacaga cgctgcgtgt caatcaaatg aaagcagaca 1473661 gagctgagct gcttgaccaa atggctgctg agggaatcga agttgaaaaa ggcgacctcg 1473721 ctgaagatgc tgtgaagctc ttaaagggaa caattgccgg aactcatttc ttccaaaacg 1473781 gcgaagtttc tatccaggat gagagctcca tgctcgtcgc ccgcgccctt gatcctaagt 1473841 cagatgaaac agtgcttgac gcgtgtgcgg cgcctggcgg aaagtcggct catatcgcag 1473901 aattaatgaa gaacaagggg agcgttacgt cgcttgatct tcacaaacat aaagtgaagc 1473961 tgatcaaaga agcggcagat cggcttggcc tgacaatcat tcatgcggaa acaatggatg 1474021 ctagaaaagc gggggaaacg tttgaaaacg aacagtttga ccgaatattg gtcgatgccc 1474081 cgtgctcagg tttcggtgtt atcagaagaa agccggacat gaaatacacg aaaaaacctg 1474141 acgacagcgc ccgtctagct gaaatccagc tgtcgatctt gagggaaatc gcaccattag 1474201 taaaaaaagg tggcactctt gtctacagta cgtgtacaat ggaccggaca gaaaatgatg 1474261 aagtaataca tgcgtttata caagaacatc ctgattttga acccgatttg tctcttgaaa 1474321 agcggctgcc tgaaaaggtg agaccctttg ttcgggatgg aaggcttcaa atccttcctc 1474381 attatttcgg aacagatggt ttctttattt gcagcatgag aaagaaggga taagcaatgg 1474441 cagaacttaa taaaacaaaa gtaagaaaag aattgcggac agagcgtccg tctatttatt 1474501 cttttgaatt agatgaaatc aaacaatggc tgacagacaa tggagagaaa ccgttccgtg 1474561 cagcccagat ctttgaatgg ctatatgaaa aacgcgtatc ttcttttgaa gatatgacaa 1474621 acctctcaaa ggatctgcgt gagaaattaa acactcgctt tgtgttaaca acgctgaaaa 1474681 cggctgttaa acaaacctct caagacggta cgatgaagtt tttgtttgag cttcatgacg 1474741 gttataccat cgaaaccgtt ttaatgagac acgagtatgg caattctgta tgtgtaacga 1474801 cacaagtcgg ctgccgtatt ggctgcacat tctgcgcgtc aacgcttgga ggcttaaaac 1474861 gaaaccttga agcaggggaa attgtcgctc aagtagtcaa agtgcaaaaa gctcttgatg 1474921 aaacggatga acgcgtcagc tctgtcgtga tcatgggaat cggcgaacct tttgataact 1474981 ttaacgaaat gctcgctttc ttgaaaatca ttaaccatga caagggcctg aatatcggtg 1475041 ctcgccatat tacggtctct acgagtggaa tcatcccgaa aatttacgaa tttgctgatc 1475101 agcaaatgca gattaacttt gcaatttctc tgcacgcgcc gaacacagaa atcagaagcc 1475161 gtttgatgcc gattaacaga gcatataaac tgcctgatct aatggaagcc gttaaatatt 1475221 atattaataa aacaggacgc cgtatcagct ttgaatacgg gctgttcgga ggcgtaaacg 1475281 accaggtgga acacgccgaa gagcttgccg acttgctgga aggagtcaaa tgccacgtga 1475341 acttgattcc ggtaaactac gtgcctgaac gggactatgt gcgcacaccg cgtgatcaga 1475401 tttttgcttt tgaaaaaacg ctgaaatccc gcggagtaaa tgtcacaatc cgaagagagc 1475461 aaggacatga cattgacgca gcctgcggtc agcttcgcgc gaaggagcgt caagacgaga 1475521 cgaggtgatg agggttgtta acagccttaa aaacagatac aggaaaaatc cgccagcata 1475581 atgaagatga tgcggggata ttcaagggga aagatgaatt tatattagcg gttgtcgctg 1475641 atggcatggg cggccatctt gctggagatg ttgcgagcaa gatggctgtg aaagccatgg 1475701 gggagaaatg gaatgaagca gagacgattc caactgcgcc ctcggaatgt gaaaaatggc 1475761 tcattgaaca gattctatcg gtaaacagca aaatatacga tcacgctcaa gcccacgaag 1475821 aatgccaagg catggggacg acgattgtat gtgcactttt tacggggaaa acggtttctg 1475881 ttgcccatat cggagacagc agatgctatt tgcttcagga cgatgatttc gttcaagtga 1475941 cagaagacca ttcgcttgta aatgaactgg ttcgcactgg agagatttcc agagaagacg 1476001 ctgaacatca tccgcgaaaa aatgtgttga cgaaggcgct tggaacagac cagttagtca 1476061 gtattgacac ccgttccttt gatatagaac ccggagacaa actgcttcta tgttctgacg 1476121 gactgacaaa taaagtggaa ggcactgagt taaaagacat cctgcaaagc gattcagctc 1476181 ctcaggaaaa agtaaacctg cttgtggaca aagccaatca gaatggcgga gaagacaaca 1476241 ttacagcagt tttgcttgag cttgctttac aagttgaaga gggtgaagat cagtgctaat 1476301 cggcaagcgg atcagcgggc gttaccaaat tctccgcgtc ataggcggcg ggggaatggc 1476361 caacgtgtat ttagctgagg atatcattct agaccgtgaa gtcgcaatta aaatcctgcg 1476421 gtttgactat gcaaatgaca atgaatttat cagacgtttc cgcagagaag cccaatccgc 1476481 atcaagcctc gatcacccga atattgtcag catttatgat ttgggcgagg aagatgatat 1476541 ttattatatt gtcatggaat acgttgaagg catgacgctt aaagaataca taacagcaaa 1476601 tgggccgctt caccctaaag aagcgctgaa catcatggag caaattgtct cagccatcgc 1476661 tcatgcccat caaaaccaga ttgttcacag agacatcaag ccgcataaca ttttgattga 1476721 tcatatggga aatatcaaag taacggattt tggaattgcg acggcactaa gttcgaccac 1476781 aatcacccat accaattcag ttctgggctc ggtccattac ttatcacctg aacaggcccg 1476841 gggcggctta gccacaaaaa aatcggatat ttatgcgctt ggaatcgttc tatttgagct 1476901 tttaaccggc cgtattccgt ttgatggaga gtcagcagtc agcatcgcct tgaagcatct 1476961 tcaagcggaa actccttcgg caaaaaggtg gaatccatcg gtcccccaaa gcgttgaaaa 1477021 catcatactc aaggcaactg ccaaagatcc ttttcatcgc tacgaaacgg ctgaagacat 1477081 ggaagcagac ataaaaacag cttttgatgc cgacagactc aatgaaaaga gatttacgat 1477141 tcaagaagat gaagaaatga caaaagcgat acctatcatt aaagatgaag aacttgctaa 1477201 agctgctggc gaaaaagaag ctgaagtgac aaccgcacaa gaaaacaaaa caaagaagaa 1477261 cggcaaaaga aaaaagtggc cgtgggtttt gctcacgata tgcctcgttt ttatcacagc 1477321 tggaattctt gctgtcactg tttttccgtc gcttttcatg cctaaggatg tcaaaatacc 1477381 tgatgtctcc ggaatggaat acgaaaaagc cgcagggctc ttggaaaaag aaggtttaca 1477441 ggttgattcc gaggtgttgg aaatctcaga tgaaaaaatt gaagagggcc tgatggtaaa 1477501 aacggatcct aaagcggata ccacagtcaa agaaggcgcc acggtcaccc tttataagag 1477561 caccggaaaa gcaaaaacgg agatcggtga tgtgacaggc caaacggtcg accaagcaaa 1477621 aaaagcgttg aaggaccaag ggtttaatca tgtaacagta aatgaagtga atgacgagaa 1477681 aaatgcgggc actgtcattg accaaaatcc ttcagcaggg actgagctgg tcccgagtga 1477741 agatcaagtc aaacttacag tcagtatcgg acccgaagac attacgctta gagacttgaa 1477801 aacctacagt aaagaagcag cgtctggata tctggaagac aacggattga agcttgtaga 1477861 aaaagaagca tactcagatg atgttccaga aggacaggtt gtcaaacaaa aaccagcagc 1477921 aggtacggca gtaaagccgg gaaacgaagt tgaagtgaca ttctctctcg gaccagagaa 1477981 aaaacctgcg aaaacagtga aagaaaaggt caagatcccc tacgaaccag aaaatgaagg 1478041 ggacgagctt caagtgcaaa tcgcggttga cgatgcggat cacagcatct ctgacactta 1478101 cgaagaattt aagataaaag agccgactga acgaacgatc gaactaaaga ttgaaccagg 1478161 ccaaaaaggg tactatcaag taatggtaaa caataaagtt gtcagctaca aaaccattga 1478221 gtatccgaaa gatgaataac aaggagggaa aatatgcctg agggcaaaat tattaaggcg 1478281 ctaagcggct tttactatgt actggatgaa tcagaggatt cagataaagt aatacaatgc 1478341 agaggaagag gcattttcag aaaaaacaaa attacccctc ttgtcggtga ttacgttgtg 1478401 tatcaagctg aaaatgacaa agaaggatat ctaatggaaa ttaaagaaag aaccaacgag 1478461 cttatcaggc cgccaatttg caacgttgat caagcggtcc ttgttttctc agcggttcag 1478521 ccttctttca gcacggcatt gctcgaccgc ttcctggttc tcgttgaggc caatgatatt 1478581 cagccgatta tatgcattac taaaatggat ctgattgaag atcaagatac agaagatacg 1478641 atacaagcct atgcagaaga ctatcggaat attggttatg acgtatacct tacctcctct 1478701 aaggaccaag atagtttagc ggacatcatc ccgcattttc aggataaaac aacggtattt 1478761 gccggtcagt ccggtgttgg gaaatcctcg cttctcaacg cgatcagtcc ggagctcgga 1478821 ttaagaacaa acgagatttc cgagcatttg ggccgcggga aacacacaac ccgccacgtg 1478881 gagctgattc acacgtccgg aggtttggtt gcagatacac cgggattcag ctcgcttgaa 1478941 tttacagaca ttgaggaaga agagctgggc tataccttcc ctgatatcag agaaaaaagc 1479001 tcttcatgca aatttagagg ctgtttacat ctgaaagagc cgaaatgtgc ggtgaaacaa 1479061 gctgttgaag acggggaatt aaagcagtat cgctatgacc attatgttga atttatgacg 1479121 gagattaaag acagaaagcc gaggtattag cataatgata aaggttgcac catctattct 1479181 ttccgctgat tttgccgctt taggcaatga gattaaagat gtagaaaaag gcggagccga 1479241 ttgtattcat attgatgtta tggacggcca ttttgtcccg aatatcacaa tcggtccgct 1479301 gattgtagaa gcggtccggc cggtaacgga tctgccgctt gatgtccatt taatgataga 1479361 agagccggat cgttatatcc cggcttttgc gaaagcaggc gcagatatcc tgtctgtgca 1479421 tgctgaggca tgtccgcacc tgcaccgtac catccagctc attaaagagc aaggagtgaa 1479481 ggccggagta gttctaaacc cgcatacccc tgtacaagtc atcgaacatg ttttcgacga 1479541 tcttgatctt gttcttttaa tgacggtgaa cccgggcttc ggcgggcaga aatttattca 1479601 ttcagtcctt cctaaaataa aagaggttaa gcgaatggcg gatgaaaaag gaaaaaaaga 1479661 tctgttaatt gaagtagacg gcggcgtcaa caaagaaacc gctccgctcg tcattgaagc 1479721 gggcgcaaat ttactcgttg ccggttcagc tgtttatggc cagtctgacc gcaaaaaagc 1479781 aatttctgaa atcagaggaa gtaaataagc agctttagaa aagagctggg catacaatag 1479841 cctaagctct ttttcctgta tgcagagaaa ggaatcagag atgaaaacaa ttaatatcgt 1479901 tgcgggaggc ccgaaaaatc tcattcccga tctaaccggc tatacggatg aacacacgct 1479961 ttggatcggt gttgacaaag gcaccgtcac tctcttagat gccgggatca ttcctgttga 1480021 agccttcgga gattttgaca gcataacgga gcaagaacgc cggcgaatag aaaaagccgc 1480081 tcccgccctt catgtgtatc aagcagaaaa agatcaaaca gatttagacc tcgcccttga 1480141 ttgggcgctg gaaaagcagc cggatattat tcagattttc ggcattacag gcggcagagc 1480201 tgatcatttt ttaggaaaca ttcagcttct gtataaaggt gtaaaaacga acataaaaat 1480261 taggctgata gacaaacaaa atcatattca aatgttccct cctggtgaat atgatattga 1480321 gaaggatgaa aataagcgat atatctcctt cataccgttt tccgaagaca tacatgagct 1480381 gaccctgacc ggttttaaat atcctctaaa taattgtcat attacgctcg gttcaacact 1480441 atgtattagt aacgaactca ttcattcacg aggtactttt tcgtttgcaa aaggcatatt 1480501 aataatgata agaagcacgg attaagcatg tgctttcatt caattgctga aaacaatgaa 1480561 caaggcggtt acgggacgtt ataggagggg acaaaaatga aattttacac cattaaattg 1480621 ccgaagtttt taggaggaat tgtccgggcg atgctgggct catttagaaa agattaatgc 1480681 ccaggggttc aaagccctct ttcaccacat aaaaacgcct gccacatatc ggggcaggcg 1480741 ttcattttgt tatacacgct caactttacc ggatttcaaa gctcgagcag atacatatac 1480801 ttttttaggt tttccgttca caaggatacg aaccttttga agattcgcgc cccaagtgcg 1480861 cttagaagcg ttcattgcgt gagaacggtt attcccagct gttgtttttt tacctgtgat 1480921 aacgcattta cgtgccattt gtttccctcc tcacttgcac aaaacatcta ctttttaaca 1480981 ttcatataat cttagatgct ttcgatatgg atactttaaa taatttacca cagctaaaaa 1481041 acgtttgcaa ctattgtttc atcatctttc aagaaaattc acttgacatc ttgcggaaac 1481101 agcagcgcta tagtatatgt agaggtacgg ccagcgatta ttgcctggtc ttttcataat 1481161 ggaaaccata tagtagaata gctgtaactc tatgcattcg aaggaggaac tagtgtgtcc 1481221 attgaattaa gaacgaagta cggacagatt gatatatcta atgaagtcat cgcgatggtt 1481281 gcaggaggcg cggcggttga ctgttacggc attgtcggca tggcctctaa aaaccagatt 1481341 aaagacggac tgactgaaat ccttcggaaa gagaatttca gcaggggtgt ccaagttcgc 1481401 caagaaggag aacagataca tatcgacatg tatatcattg tcagctacgg cacgaaaatt 1481461 tctgaagtgg cacataatgt ccaaacaaaa gtaaagtaca cagtaaatca aaccatcgga 1481521 ctggcagtgg attctgtcaa tatttatgtc caaggcgtac gagtgacgaa cccgtagtta 1481581 ggaggagtag gattgtctat cagaacatta gacggcagaa cctttgccga gatgattctt 1481641 gcgggagcgc agaatctgtc tcaaaacgcc agtgcagttg atgcactgaa cgtgttcccg 1481701 gtgccggacg gtgatacggg aacaaatatg aacctgtcga tgacttccgg agcaagagaa 1481761 gttgaacaaa tggatacgga tgatatcggg aaggtgggct ccgcgttatc taaagggctg 1481821 ctcatgggag cacgcggaaa ttcaggagtt atcctatccc aattgttccg cggatttagc 1481881 aaaaacattg aaacgaaaaa agaaattaat gcacttgagt ttgccgctgc gctgcaagca 1481941 ggtgtagaca tggcgtataa agctgtcatg aaacctgtag agggcaccat tttaacagtt 1482001 gcaaaagacg ctgcaaaaaa agcaatgatc ttagcagaaa aagaaaccga tatcactgcg 1482061 ctgatgactg cagtgacaga agaagcagag gcgtctttaa accgcacccc tgaattgcta 1482121 cctgtcctaa aggaagtagg agttgtcgat agcgggggca aaggcctgct ctgtgtgtat 1482181 gaaggtttcc ttgcttcatt aaaaggtgaa actgtacctc agaaagcagt tcttccgtca 1482241 cttgacgaca tggtcagcgc agagcatcac aagagcgcgc aaagcatgat gaataccgaa 1482301 gatattgaat ttggattctg taccgaagtg atggttaggc ttgatcagac aaaaagagag 1482361 ttcgacgaag gcacgttcag gcaagacctc agccagttcg gagattctct gcttgtgatt 1482421 gcggatgaat cgctggcgaa ggttcatatt catgctgaag agccgggaaa cgtgttaaac 1482481 tacgcccagc attacggtga attgatcaaa ataaaaatag aaaatatgag agaacagcat 1482541 acctctatca tcagtcaaga aagcaaacct gcagacaacg aaacaccgcc ggcaaaacag 1482601 ccgtatggca ttgtgactgt agcgatggga gaaggaattg cagacctatt taaaagcatt 1482661 ggcgcttctg ttgtgattga aggcggccag accatgaacc caagcactga ggatattgtt 1482721 gatgccgtga agtctgtaaa tgcagatacg gtatttatcc tgcctaacaa ctccaacatt 1482781 atcatggctg ctaaccaagc ggccagcgta gtggatgaac aggtttttgt cattcctgct 1482841 aaaacggttc cgcaagggat gtcagctctg ctggctttta acccggatca agaagctgaa 1482901 gcgaacgagg ccaatatgct aagcgccatt cagcaagtaa aaagcggaca ggtgacgttc 1482961 tcagtcagag atactcatat tgacggtaaa gacattaaaa aaggcgactt tatgggcatt 1483021 ctgaatggaa cgattatcgg cacttctgaa aatcagctgt cagccgcgaa aatgctgctg 1483081 tcagaaatga tcggagaaga tgatgaaatc gtgaccattc tatatggtga ggatgcgtct 1483141 caggaagaag ctgagcagct tgaagcgttt ctcagtgaaa agtacgagga gattgaggtt 1483201 gagatccaca atgggaaaca gcctctgtat tcgtatatag tttcagcaga atagaagggc 1483261 aatttgccct tctattctta tgtctgcttt taagtgcggc agcgctgtaa cgcgcccgct 1483321 tgccatttta tatctgatca attagtctag aagcaaagcg ctaataagct ctggttcata 1483381 aggaggaata gcatgaaata cagaagcgtt tttgatatta tcggcccggt tatgatcggt 1483441 ccgtccagct ctcatacagc gggagctgct agaatcggga gagtggccag aagtttattt 1483501 ggcagagagc ctgagcgcat cattgtatct ttttacggct cgtttgcgga aacgtataag 1483561 ggccacggca cagatgtcgc gattatcggc ggattgcttg attttgatac attcgatgaa 1483621 cggattaaaa ccgctataca aattgcagaa gctaaaggaa ttgatataga gtttcgggta 1483681 gaagacgcag tcccggtcca cccgaacaca gcaaaaatca ccatttctga tgaaaagggt 1483741 gagctggaac tgacgggtat ttcgattggc ggaggaaaga ttgaaatcac agaattgaat 1483801 ggttttgagc tccggctgtc aggaaatcat ccggccatat tagttgttca taatgacaag 1483861 tttggcacaa ttgccggtgt tgccaatgtt ctggcgaaat tttcaatcaa cgtaggacat 1483921 atggaagtag cccggaaaga tatcggccag cttgcgctga tgacaataga ggtcgatcaa 1483981 aatattgacg accacattct cgacgagctg tcgaagctgc cgaatattat tcaagtgaca 1484041 aagattgctg actagcgaaa agggtcagga ggagccagtt atgtttcgta atgtaaaaga 1484101 attaattgag attactaaag aaaaacaaat attgatctct gatgtgatga tagctcaaga 1484161 gatggaagta acagaaaaaa caaaagagga catttttcag cagatggatc ataacctgtc 1484221 tgttatggaa gcggcggttc agaaaggact cgagggagtt acgagccaaa cgggcttaac 1484281 aggcggagat gccgttaaat tgcaggccta tattcgatca ggaaaaagcc tgtctggccc 1484341 gctgatttta gatgctgtat cgaaagccgt tgcaacaaat gaagtaaatg cagccatggg 1484401 aaccatctgt gcgacaccga ctgcaggttc tgccggtgtg gtgcccggta cgttatttgc 1484461 tgtaaaagaa aagctgaatc caacaagaga acaaatgatc cgctttttgt ttacagccgg 1484521 ggctttcgga tttgtcgtgg ccaataacgc aagcatttcc ggcgccgccg gaggatgtca 1484581 ggcagaggtt ggatcagctt caggcatggc ggctgcggct attgttgaaa tggcaggagg 1484641 aacacccgaa caaagcgcgg aagccatggc cattacatta aaaaatatgc taggcctcgt 1484701 gtgcgaccct gttgcagggc ttgttgaggt gccttgcgtg aaacggaatg cgatgggcgc 1484761 gtcaaatgcg atgattgctg ctgatatggc attggcgggc attacaagcc gtattccatg 1484821 tgatgaggtt atcgatgcca tgtataaaat aggccaaacg atgccaactg cacttagaga 1484881 aacaggccag ggcggtttag cggcaacacc gacaggaaga gaattagaga aaaaaatttt 1484941 cggaggagcg ctaggttcac gtgaaacaac atcagcaaac tagtatagct aacattaagg 1485001 gtattgggcc ggaaacagaa aaaacattga atgaactcgg tatttatgac atttctgatc 1485061 ttctgaatta tttcccttat cgctatgatg actacgagct gagggattta gaagaagtaa 1485121 agcatgatga aagagtcaca gtcgaaggga aggttcattc agagccttct cttacctatt 1485181 acggaaaaaa acgaaacagg ctgacattca ggcttctggt cggccactat ttaatcacag 1485241 ccgtatgttt taaccggcct tatttgaaga agaagctttc gctcggctct gtggtgacgg 1485301 tttcaggtaa atgggacaag caccgccaaa ccatctctgt tcaggagttg aaaaacgggc 1485361 cgcatcaaga agacaaaagc attgaaccag tgtattctgt gaaagaaaat gttaccgtca 1485421 aaatgatgag gcgctttatt cagcaggcgc tgacccaata tgcagactca cttcctgatc 1485481 ctcttccgga aaagctaaga aaaagctata aactgcctga ctattatcaa gcgttaaaag 1485541 caatgcacca gcctgaaaca agggaagcat taaagcttgc cagacggcgg tttgtttatg 1485601 aagaattttt gttgtttcag ttgaaaatgc aggcgttccg aaaggcggaa agagagcaga 1485661 cacaagggat acggcagcgt ttttcaaacg aagaactcat gagatttatc aaaagcctcc 1485721 cgtttcccct cacaaacgcc cagtcacgcg ttcttcgcga aataacagca gacatgtctt 1485781 ctccatacag aatgaaccgt cttcttcaag gggacgttgg atcaggaaaa acggcagtcg 1485841 ccgccattgc actgtatgcc gcgatcctat ccggatacca aggagcgctc atggtgccga 1485901 cagaaattct ggccgagcag catgctgatt cgctcgtttc gctatttgaa aaatgggacg 1485961 tcagcgttgc tcttttgaca agctctgtta aaggaaagcg gcgaaaagaa ctgcttgagc 1486021 gtcttgcggc gggtgagatt gatattcttg taggaaccca tgctttaatc caagacgagg 1486081 tggagtttaa ggcgttgagt ctcgttatta ctgatgaaca gcacagattt ggagttgagc 1486141 agcgcaaaaa gcttcggaac aaagggcagg atcccgatgt tctctttatg acagccactc 1486201 caatcccaag aacattagcg atcacagtat tcggtgaaat ggatgtatct gtcattgatg 1486261 agatgccggc tggacgaaag cgaattgaaa cctattgggt aaaacatgac atgcttgatc 1486321 gtattttggc atttgtcgaa aaagaattaa agcaaggcag gcaggcttat atcatctgtc 1486381 cgctgattga agaatcagat aagcttgatg tgcaaaacgc cattgacgtg tacaatatgc 1486441 tttctgatat ttttcgggga aaatggaatg tcggccttat gcatggaaag ctgcattccg 1486501 atgaaaaaga tcaggtcatg agagaattca gcgcaaatca ctgtcaaatt ctcgtatcaa 1486561 ccactgttgt ggaggttggc gtaaatgttc cgaatgcaac aattatggtg atttatgacg 1486621 ccgaccgttt cggactatca cagcttcacc agctgcgcgg ccgtgttgga cggggtgagc 1486681 atcaatcttt ctgtattctg atggctgatc caaaatcaga aacagggaaa gaacggatga 1486741 ggatcatgtc ggagaccaat gacggtttcg agctgtctga aaaggatctg gaactgagag 1486801 gtcccggtga tttcttcggg aaaaaacaaa gcggaatgcc ggaatttaaa gtggcggaca 1486861 tggttcatga ttacagagcg cttgaaacgg caaggcagga tgctgcgaat cttgtggctt 1486921 ctgacgcgtt ctggaaggag ccggaatacg ctgtgttaag agatgaattg ctgaagagcg 1486981 gagtaatgga cggggaaaaa ttaagctgag tatcagaagt ttttggtgtt cagccagaaa 1487041 caatcgttgc attccaatct atgaaattat atactactat tagtacctag tcttaattgt 1487101 ccggatggtg tttagatatg agaagaaata agagagaacg ccaggaatta cttcagcaga 1487161 cgattcaagc aacccccttt attacagatg aagaactagc gggtaaattc ggggtgagca 1487221 tccagacgat acgtttggac cgcttagagc tttccatacc tgaactgaga gaaagaatta 1487281 agaacgtggc agagaaaaca cttgaggacg aagtgaagtc cctgtcactt gatgaagtta 1487341 tcggagaaat tattgacctt gagctggatg atcaggcgat atccatttta gaaataaaac 1487401 aggagcacgt gttcagccgg aatcagattg cgagaggaca ccatttattt gcacaggcga 1487461 attctttggc cgttgcagtc attgatgacg agctggcgct gactgcaagt gcagacatcc 1487521 gctttacaag acaggtaaag cagggtgaac gtgtcgtagc aaaagcgaaa gtgacggctg 1487581 tcgaaaaaga aaaaggaaga acggttgtcg aagtgaacag ctacgttggc gaagaaattg 1487641 ttttttctgg acgctttgac atgtatcgtt caaaacattc ataaaggtgg agcatgcatg 1487701 agaatagctg tagatgcaat gggaggagac cacgctccca aagctgttat tgacggagtt 1487761 ataaaaggta tagaggcatt tgatgatctc catatcacac ttgtcggtga caaaacaacg 1487821 atagaatcac atttaacaac tacatcagat cgcatcacgg tgctgcacgc agatgaagtg 1487881 attgagccta cggatgaacc ggtccgtgcc gtgcgaagaa aaaagaactc atctatggtt 1487941 cttatggcgc aggaggttgc ggaaaacaga gctgacgcct gcatttcagc gggaaatacc 1488001 ggtgcattaa tgacagccgg tctctttatt gtcgggagaa ttaaaggaat tgaccgtccg 1488061 gcgcttgctc cgacacttcc gactgtttcg ggagacggat ttcttctcct tgatgtcggc 1488121 gccaatgtcg atgccaaacc ggagcacctc gttcaatatg ccatcatggg ttctgtttat 1488181 tctcagcaag tgcgcggtgt cacttcaccg agagtcggac ttttaaatgt cggaacagaa 1488241 gataaaaaag gaaacgaact gacgaagcag acgtttcaaa ttttaaaaga aacagcaaac 1488301 atcaatttta tcggaaacgt ggaagcgcga gaccttttag atgatgtggc ggatgttgta 1488361 gtaacagacg gctttaccgg gaatgttaca ctcaaaacgc tggaaggctc tgcgttgtca 1488421 atttttaaaa tgatgagaga cgtaatgacg tctactttga catccaagct tgcagcagct 1488481 gtgctgaaac caaaattgaa agaaatgaaa atgaaaatgg agtattcgaa ttatggcgga 1488541 gcaagtcttt ttggcttaaa agcgcctgtg atcaaggcgc acggctcttc agattcaaat 1488601 gctgtattcc atgcgattcg gcaagcaaga gagatggtca gccaaaatgt ggctgcgctc 1488661 attcaggaag aagtgaaaga agaaaaaaca gatgagtagt ctggaggttt ttacatcatg 1488721 agtaagattg catttttatt cccgggtcag ggatcacaat ttatcggcat gggaaaagag 1488781 ctttatgagc aggtgcctgc tgcaaagcgt ctgtttgatg aagccgatga aacgttggaa 1488841 acaaaactca gctcgcttat ttttgagggg gatgctgaag aattaacact tacatacaat 1488901 gcgcagcctg ctttgcttac gacaagcatc gctgttcttg agaaatttaa agaatctggc 1488961 attacacctg atttcacagc aggacacagc cttggtgaat attctgcact ggttgcggct 1489021 ggcgctctgt ctttcaaaga tgctgtttat actgtcagaa agcgcggaga gtttatgaat 1489081 gaagcggtgc cggctggcga aggagcaatg gctgcgattc tcggcatgga tgctgaagca 1489141 ttaaagcaag taaccgataa agtcacagag gaaggcaacc ttgtacagct tgcgaatctc 1489201 aactgtcctg gccaaatcgt catttccgga acagctaaag gggttgagct tgcatctgaa 1489261 ctggcaaaag agaacggcgc aaaacgcgca attccgcttg aagtaagcgg tccgttccat 1489321 tctgaactga tgaaaccggc tgctgaaaag ctgaaagagg tattggacgc ctgtgacata 1489381 aaagacgctg acgttccggt catctcaaat gtttctgctg acgtgatgac tgaaaaagca 1489441 gatatcaaag aaaaacttat tgagcagctt tactctccgg ttcgttttga ggaaagcatt 1489501 aacaagctga tcgcagaggg tgttacgact tttattgaaa tcggtcccgg aaaagtgctt 1489561 tcaggccttg tgaaaaaagt gaatagacgg ttaaaaacaa ttgctgtatc agatccggaa 1489621 acgatcgagc tggcaattca aacgcttaag gaggagaatg ataatgctta atgataaaac 1489681 ggctattgtc actggcgcat cccgcggaat cggccgctca atcgcccttg atctggcaaa 1489741 aagcggagca aatgttgtcg tgaactactc cggcaatgaa gcgaaagcaa atgaagtggt 1489801 agatgaaatc aaatcaatgg gcagaaaagc aattgctgta aaagcggatg tatcaaatcc 1489861 cgaagatgta caaaacatga taaaagaaac attgtctgtt ttttctacga ttgacattct 1489921 ggttaataat gcgggaatta caagagacaa tctcatcatg agaatgaaag aagacgaatg 1489981 ggatgacgtc attaacatta acctgaaggg tgttttcaac tgcacaaaag ctgttacaag 1490041 acaaatgatg aaacagcgtt caggccgcat tattaacgta tcgtctatcg tcggcgtcag 1490101 cggaaaccct ggacaagcca actacgtggc tgcaaaagcc ggcgtcatcg gtttaaccaa 1490161 atcttctgct aaagagctcg ccagccgaaa tattacggta aacgcaatag cgccaggatt 1490221 tatctcaact gatatgacag ataaacttgc aaaagacgtt caagacgaaa tgctgaaaca 1490281 aattccgctc gcgcgctttg gtgaacctag cgatgtcagc agtgttgtca cgttcctagc 1490341 ttcagaggga gctcgttata tgacaggcca aacgcttcat attgacggcg gaatggtgat 1490401 gtaagttttt tctcgaaaat ttcatcgtag tttctctagt tttttaaaaa cgaatccact 1490461 ataatacttg aggggaggtg aattgctatg gcagacacat tagagcgtgt aacgaaaatc 1490521 atcgtagatc gccttggcgt tgatgaagca gacgtcaaac ttgaagcttc tttcaaggaa 1490581 gacttaggtg ctgattccct agatgtagtt gagcttgtta tggaacttga agacgagttt 1490641 gatatggaga tttctgacga agatgctgaa aagattgcaa cagtcggcga cgctgtgaac 1490701 tacatacaaa accagcaata agctgatgct aaaagtcccg ccgaaacgcg gggctttagc 1490761 cctttattcg tgcagttatt acagcatgcc gcttttacgc gcgctgtatc cggtttagtc 1490821 agagaagcgc ggtgaacctg atgtgcctat ggaggttact atgtcaaaac actcacatta 1490881 taaagataaa aaaaagttct ataaaaaagt agaacaattt aaagagtttc aagaacggat 1490941 ttcggttcac tttcaaaatg aaaagctttt gtatcaagca tttacacatt catcttatgt 1491001 gaatgagcat cggaaaaagc cgtatgaaga taatgaaagg cttgaatttt taggtgacgc 1491061 tgttttggaa ctgacgatct ccagattctt atttgccaaa tacccggcta tgagtgaagg 1491121 agatttgacg aaattgagag ccgcaattgt ttgcgaaccg tctctcgttt cattggctca 1491181 cgagctgtca ttcggcgatc ttgtcctgtt gggtaaaggc gaggaaatga caggcggaag 1491241 aaagcgtcct gctctattgg cggatgtttt tgaggcattt atcggagcct tgtaccttga 1491301 ccaaggatta gagccggtcg aaagtttctt aaaagtttat gtgttcccta aaattaacga 1491361 tggtgctttt tctcatgtga tggatttcaa aagccagctg caggaatacg tgcagcggga 1491421 cggcaaaggc tctctggagt ataaaatctc caacgaaaaa ggacctgcgc acaaccgtga 1491481 atttgaagcc atcgtatctc taaaaggtga accactcgga gtcggaaacg gccgttcaaa 1491541 gaaagaagcc gaacagcacg ctgctcagga agctttagct aaattgcaaa aacaccatac 1491601 gaaacaataa aatccccctt atgactcagg gggatttcag tatgtatgcc gtcttatttg 1491661 accaatgttt atgatagaat tgaaatactt attacataag gaggatcgct atgttcctca 1491721 aacgtttaga cgttatagga tttaaatcat ttgcagaacg gatttccgta gacttcgtta 1491781 aaggcgtgac agcagttgtc gggccgaacg gaagcggaaa aagcaacatc acggatgcca 1491841 ttcgctgggt tctcggcgaa caatcggcac gctctcttcg cggcggaaaa atggaagaca 1491901 tcatttttgc tgggagtgat tcaagaaagc gattaaatct agctgaagtt acgcttactc 1491961 ttgataatga tgatcatttc ttgccaattg acttccacga ggtgagtgtc acaagacgtg 1492021 tgtacagatc aggtgagagt gagtttctga ttaacaatca gccatgccgc ttgaaagata 1492081 ttattgattt atttatggac tctgggcttg gtaaagaagc attttctatt atcagccaag 1492141 ggaaagtgga agagatcctg agcagcaaag cggaggatcg ccgcagtatc tttgaagaag 1492201 cggccggggt gcttaaatat aaaacgagaa agaaaaaagc agaaaataaa ctgtttgaga 1492261 cacaggacaa tctaaatcgg gtagaagata tattacatga gcttgaagga caggttgaac 1492321 ctcttaaaat tcaagcttca atagcgaaag actaccttga gaaaaagaaa gagctggagc 1492381 atgttgaaat tgcgctgact gcctatgata tcgaagagct gcatggtaaa tggtcgactc 1492441 ttaaagagaa agtgcagatg gcaaaagaag aagagcttgc tgaatcgtct gctatttctg 1492501 cgaaagaagc aaagattgag gatacaaggg acaaaataca agcgcttgat gagtcagtag 1492561 atgagctcca gcaagtttta ctggtaacta gtgaagagct ggaaaagctt gaaggccgta 1492621 aagaagtcct gaaagaacga aagaaaaacg ctgtgcaaaa ccaagaacag cttgaagaag 1492681 ccatcgttca gttccagcaa aaagaaacgg ttctgaaaga agagctttcg aagcaggaag 1492741 ctgtcttcga aacgcttcag gctgaggtga agcagttaag ggcgcaagta aaagaaaaac 1492801 agcaggctct cagtcttcac aatgaaaatg tcgaagagaa aatcgagcag ctgaaaagtg 1492861 attattttga gctgttaaac agccaggctt cgatacgcaa cgaactccag cttcttgatg 1492921 accagatgtc ccaatccgct gtcacattgc agagacttgc ggacaacaat gaaaagcacc 1492981 tgcaggaacg gcatgatatt tctgcgcgta aagccgcatg tgaaacggaa tttgcccgaa 1493041 ttgagcagga gattcacagt caagtcggtg catatcgtga tatgcagaca aaatatgagc 1493101 agaaaaagcg ccaatacgaa aaaaatgaat ccgctctgta tcaggcatac caatacgttc 1493161 agcaagcgag atcaaaaaag gacatgcttg agacgatgca gggagatttc tccggctttt 1493221 atcaaggtgt taaagaagtg ctgaaagcga aagagcgcct tggcggaatt cgcggagcgg 1493281 ttcttgagct gatttctaca gaacagaagt atgaaacggc cattgaaata gcgctcggcg 1493341 cttctgctca acacgtcgtg accgacgatg aacaatctgc ccgcaaagcg attcaatatt 1493401 taaagcagaa ttccttcggc cgggcgacgt ttctgcctct ttctgttatt agagaccgcc 1493461 agcttcaaag ccgtgacgcg gaaacagccg cccggcattc atcatttctc ggggttgcca 1493521 gtgaacttgt cacatttgat cctgcgtatc gaagcgtcat ccagaatctt cttggaaccg 1493581 ttctgatcac agaggactta aagggtgcaa acgagcttgc gaagcttctc gggcaccggt 1493641 accgcatcgt aacccttgag ggagatgttg tgaaccccgg tggttcaatg acgggcggcg 1493701 cggttaaaaa gaaaaataac tccctccttg gaagaagccg ggagctagaa gatgtgacga 1493761 aacggctcgc tgaaatggaa gagaaaacgg cactgcttga acaagaggtc aaaaccctta 1493821 agcactccat tcaggatatg gagaaaaaac tggctgactt aagagaaacc ggggaaggct 1493881 taaggttaaa gcagcaggat gtgaaaggcc agctgtacga acttcaagtt gccgagaaaa 1493941 atatcaatac ccatttagag ctctatgatc aagaaaaatc tgctctgtca gaaagcgatg 1494001 aagagagaaa agtgcgcaaa cgcaagcttg aagaagagct ctctgccgta tctgaaaaga 1494061 tgaaacagct tgaagaggac atagacagac tgacaaaaca aaaacaaacg caatcctcaa 1494121 cgaaagagtc tctctccaac gagctgactg agctgaagat cgcagcggcc aaaaaagagc 1494181 aggcttgcaa gggggaagag gacaaccttg ccagattaaa gaaagagctc actgaaacag 1494241 agcttgcgtt aaaagaagca aaagaagact taagcttctt aacgtcagag atgtcatcta 1494301 gcaccagcgg cgaagaaaag ctggaagaag cagcaaaaca taaattgaat gacaaaacga 1494361 aaacgatcga actgattgca ttaaggcgcg atcagcgcat caagcttcag catgggcttg 1494421 atacgtatga gcgtgagctg aaagaaatga aacgcctgta taaacaaaaa acaacgctct 1494481 taaaagacga agaagtcaaa cttggacgaa tggaagtcga gcttgataat ttactccaat 1494541 acttacggga ggaatacagc ttgtcctttg agggggcaaa agagaaatat cagcttgaaa 1494601 ctgatccaga ggaagccaga aagcgcgtga agctgattaa actcgcaatt gaagagctgg 1494661 gtaccgtgaa cctcggaagc atagatgagt ttgagagggt caacgaacgg tacaagtttc 1494721 tgtcggaaca aaaagaagat ttaacagaag cgaaaaatac cttgttccaa gtgattgaag 1494781 aaatggatga agaaatgacg aagcgcttta acgacacatt cgtccaaatc cgctcacact 1494841 ttgatcaagt tttccgctcc ttattcggag gagggcgagc tgaactgagg ctcaccgatc 1494901 ctaacgatct gcttcattca ggagtcgaga ttatcgctca gccgccgggg aaaaagctgc 1494961 aaaacttaaa cctcctgtca ggcggagagc gtgcgcttac tgctatagcg ctcttattct 1495021 caatcctaaa ggttcgtcca gtgccgtttt gcgtccttga cgaagtagag gctgcgctcg 1495081 acgaagcgaa tgtgttccga tttgcgcagt atttaaaaaa atacagcagc gatactcagt 1495141 ttattgtgat tacccacaga aaaggaacga tggaggaagc ggatgtgctt tatggcgtaa 1495201 ccatgcagga atccggtgtt tccaaggtaa tttcagttaa gctggaagaa acaaaagaat 1495261 tcgttcagta acgaggaaag aggttaaaag atgagctttt ttaaaaaatt aaaagagaaa 1495321 atcacaaaac agacagattc cgtatctgaa aagtttaagg atggccttga aaaaacaaga 1495381 aactcctttc aaaacaaagt gaatgatctt gtatcccgtt accgtaaagt ggatgaggat 1495441 ttcttcgaag agcttgaaga ggttcttatc agcgcggatg tcggttttac aaccgttatg 1495501 gaattaatag atgagctgaa aaaagaagtc aaacgcagaa atattcaaga tccaaaggaa 1495561 gtccagtcag tgatttctga gaaactggtc gagatttata acagcggaga tgagcaaatt 1495621 tcagaactga acatccagga tgggcgttta aacgtaatcc ttctggtagg tgtaaacggc 1495681 gtcgggaaaa caacaacgat cggaaagctt gctcataaaa tgaaacaaga aggaaaatct 1495741 gttgtacttg ccgccggaga cacttttaga gcgggagcca ttgaacagct ggaagtatgg 1495801 ggagagcgta caggagtgcc tgtcattaag cagacggcag gaagcgatcc ggcggctgtc 1495861 atctacgatg ctgttcatgc tgcgaaagca agaaatgccg atgtattaat ttgtgatacg 1495921 gcagggcgtc tccaaaacaa agtaaatctc atgaaagagc ttgaaaaagt aaaacgtgtt 1495981 atcgaaagag aagttcctga agctccgcat gaggtgctgc ttgcccttga tgccacgacc 1496041 ggccaaaatg caatggctca ggcaaaagaa ttctctaaag caacaaatgt taccggcatt 1496101 gctttaacga agcttgacgg tacggcaaaa ggcggtatcg tccttgcgat tcgcaacgag 1496161 cttcacatcc cggttaaact agtcggttta ggagaaaaag ttgatgacct tcaggaattt 1496221 gatccagaat cctatgtgta cggactcttt tcagatttag tggaaaaagc cgacgattaa 1496281 gaaaaaggcc ccaacatctt ggggcctttt tcttttttat cttcttactt gataggcgaa 1496341 atgataaagg ctgttatcag tggataccag tcttgactca ccagaaaaaa ctctgaatgg 1496401 gatgatgtca tagtaatgaa cggaaacaga tgtgtaatac gtatagtaac cagcagctgg 1496461 ccccaaatac attggaacct caaatgttcc gtttgcatca gtcgttcctg aagcagtttg 1496521 tgttgtgttt ccgaccttcg tgtccgcttc aaatcttacg ggcgcgtttg gcactggctg 1496581 tccgttttgg tcgagtaatt tgccgcttac tgtaatattg tacttgactc gccaatattg 1496641 accttgtccg taattgattt taccgtatac ccctccatct gtgctgatat ttgtgattga 1496701 ggccttataa ggtgcctcag cagcgtctgc ttgctgtgcc gggaaaccta ttgtaaacag 1496761 ggctgccaga cataacataa acaataaacc gatttttttc ataaaaatcc tccttaaaat 1496821 agggttcata tacaatatcg gaataaattg gatgatattt agcgtatttt ggaaaagtta 1496881 atcgccgctt tgacaagata aaaacttgac agtgtcatta aaaccgtgta aactaagtta 1496941 tcgtaaaggg atttgactta acaaagggga gagctcaaat gtcactcgaa aagacaacga 1497001 gaatgaatta tctgtttgat ttttatcagt cgttgttgac gtcaaaacag aagagctata 1497061 tgtcgcttta ttatttggac gatttctccc taggcgaaat agccgaagaa tatgaggttt 1497121 caagacaagc tgtttatgat aacatcaaac gaacagaagc aatgcttgaa caatatgaag 1497181 aaaagctgct ccttttgaaa aagtttcagg agcgtaaaga gatgtttaat aagctgaagg 1497241 agcttgcttc cggttcaaaa gaagaggaag aaattacagc tctgattgaa gcgcttgaga 1497301 aattagatta ggaggcggca aactatggca tttgaaggat tagccgaccg actgcagcag 1497361 acgatttcta aaatccgcgg aaaagggaaa gtcagcgaac aagatgtaaa agagatgatg 1497421 cgtgaggtcc gtcttgcgct gcttgaggct gacgttaact ttaaagtagt caaggatttt 1497481 gtcaaaaaag taagtgaacg cgctgtaggc caagacgtca tgaaaagtct gacgcccggc 1497541 cagcaggtca ttaaagttgt tcaagaggaa ctgactgagc tgatgggcgg cgaagagagc 1497601 aaaatcgccg tcgcaaaaag gccgccgact gttattatga tggtcggtct ccaaggtgcc 1497661 ggtaaaacga caacaagcgg taagcttgcg aatctgctgc gcaaaaagca taatcgcaaa 1497721 ccgatgctgg ttgctgccga tatttaccgc ccagccgcaa ttaagcagct ggaaacactc 1497781 ggcaaacagc ttgatatgcc tgttttctct cttggcgatc aggtcagtcc tgtagaaata 1497841 gctaaacagg ctattgagaa agccaaggaa gaacattatg actacgtcat tttggatacg 1497901 gcagggcgct tgcatatcga ccatgaactg atggatgaac tgaccaacgt caaagaaatc 1497961 gcgaatccgg aagaaatttt cctggttgtc gattcaatga ccggtcagga cgctgtgaat 1498021 gttgccaaaa gctttaatga acagctcggt ttaaccggtg ttgtgttgac taagctggat 1498081 ggagacacac gcggcggggc tgcgctttct attcgcgctg tcacaaacac gccaattaag 1498141 tttgcaggtt tgggcgaaaa gcttgatgcg ttagagccgt tccatcctga acgcatggca 1498201 tcaaggattc tcggcatggg cgacgtgctg acattgattg aaaaagcaca ggccagcgtt 1498261 gatgaagaca aagccaaaga gctggaacaa aaaatgagaa cgatgagctt cacattggac 1498321 gattttctgg agcagctcgg gcaagtcaga aacatggggc cgcttgatga gcttctgcaa 1498381 atgatgccgg gtgcaggtaa aatgaagggc ctgaaaaaca tccaagttga tgaaaaacag 1498441 ctgaatcatg tggaagcaat catcaaatca atgactgttc ttgaaaaaga acagccggat 1498501 attatcaatg ccagccggcg gaagcggatt gcaaaaggaa gcgggacatc cgtacaggaa 1498561 gtcaaccgtc tgcttaagca gtttgatgaa atgaaaaaaa tgatgaagca gatgacaaac 1498621 atgtcaaaag gcaagaaaaa agggtttaag ctacctttta tgtaatcggt tatacatgat 1498681 aaaaccgttg ttaagaaaaa acactttaca aacactttta tcattgttaa tatactatct 1498741 tgttgaaata ttttcggagg tgctagtaaa atggcagtaa aaattcgttt aaaacgtatg 1498801 ggagcaaaaa aatctccttt ctatcgtatt gttgtagcag attctcgttc accacgtgac 1498861 ggccgtttca tcgaaacagt cggaacttac aacccggttg caaaaccagc ggaagtaaaa 1498921 attgacgaag agcttgctct taaatggctt caaactggag cgaaaccatc tgatacagtt 1498981 cgcaacttgt tctctagcca aggaatcatg gaaaaattcc acaacgctaa acaaggcaag 1499041 taatgactga tcaacacttg gaagatttga ttgtccacat tgtgacgccg cttgttgatc 1499101 atccagatga cattcgcgtc ataagagaag aaaccgatca aaagattgcg ctgcgcttat 1499161 ctgtccataa gtcagatacc ggtaaagtta tcggaaagca aggccggact gcaaaagcga 1499221 ttcgaacagc tgtatttgca gctggcgtac agtcttctaa gaaagttcaa tttgaaatat 1499281 ttgactaaaa gggagagggc cggcacctcc ccttttttta cacgcaaaaa aagggtaaac 1499341 tgatagaagc ttaggcaaaa tagaaaagcc tggacgagta aaagttttaa aagcggggag 1499401 cttggtgcga tgcaaattat tcaccgtgta gccgttatgc aagtcttaac cgagcgcagt 1499461 aaagaaaagc ttttagcttc ttttgctgag aagaaacaaa tgcttgaacg agaatgcagc 1499521 cagctctatt ttcagcttag aaaacatgag aaagaacagc aaaaccctaa tatgattgaa 1499581 caatttaaaa aggcaataga aaagcgaaaa gatgatataa aaatcattga ttttcaaatt 1499641 gctcaagtac atacattgcc gcttggcagt gagttgaaag aaaaggaagt cgatgcgctg 1499701 ctgacgattg aagccgggga tgactggcat gagaaaacag cagcgaacac catcgtcata 1499761 aaagacggaa aagtaattga aattcgccag aggtgatcat atgacaaagc gatggtttaa 1499821 tgtaggcaaa atcgtaaata cccacggaat caaaggcgaa gtgcgggtga tttcaaaaac 1499881 agattttgcc gaagaacgat acaagccggg aaacacgctg tatttgttta tggacggccg 1499941 taacgaacca gtggaggtaa cggtaaacac acatagactg cataagcaat ttcatctcct 1500001 gcagtttaaa gaaagacaaa acctaaatga agtagaagag ctgaaaaacg caatcattaa 1500061 agttcctgaa gaagaattag gagagctgaa tgagggtgaa ttttatttcc acgaaattat 1500121 tgggtgtgaa gtatttactg aagaaggcga actcatcgga aaggtcaaag aaattttgac 1500181 gcctggagcc aatgacgttt gggtcatcgg acgaaaagga aaaaaagacg cactcattcc 1500241 ttacattgaa tcagtggtta aacatatcga tgtcagggaa aagaaaattg agattgaact 1500301 catggaaggg ttaatagacg aatgaaaatc gattttttga cgctgtttcc cgaaatgttt 1500361 gaaggcgtgc tcggctcatc gattcttcaa aaagcccagg aaaaagatgc ggtgcagttt 1500421 caagtcgtaa atttccgaga gtactctgat aacaagcaca atactgttga tgattatcct 1500481 tatggcggcg gggcaggcat ggttctcaag ccccagcctg tttttgacgc ggtcgaggac 1500541 ctgacatcaa aggcagccgc tgctccgcgt attatcctcg tatgcccgca aggtgagcgt 1500601 tttacccaaa aaaaagccga acaattagct aaggaagagc atttgctgtt catttgcggc 1500661 cactatgaag gctatgatga acgcattcgc gagcacttgg taacggatga aatatcaatt 1500721 ggcgactttg ttctgacggg cggtgagctc cctgcaatga tgatcgcaga cagtgtggtc 1500781 agactgcttc cgggtgtact gggtaaagag gcttcccata ttgaggattc cttcagcacc 1500841 ggacttttag agcacccgca ttatacaaga ccggcagatt acaaaggttt aaaagtgcct 1500901 gaaacactct tgtcaggaaa ccatgcaaaa attgaagaat ggcggaataa agaatcgatc 1500961 agaaggacct acctaagacg tccggatctg ttgaaagacc acccgcttac agagcagcaa 1501021 agaaagtgga tttctgaatg ggaaaaagaa tagattttat tgcataggct atgaaattgt 1501081 gataagatac tacttgtggc ttaagcgggc ttatccgctg caagcttgaa aacgatgttc 1501141 cgctgtgccg gtttttgtgg ccaagagcat ctgttggaag gagttgaaaa cgatgcaaaa 1501201 actaattgaa gatatcacaa aagaacagct tcgtactgat cttcctgcgt tccgtcctgg 1501261 tgacacttta cgtgtacacg ttaaagttgt tgagggtaac cgtgagcgta tccagatctt 1501321 tgaaggtgtt gtgattaagc gtcgtggtgg tggaatcagc gaaacgttca cagttcgtaa 1501381 gatttcttac ggtgttggcg ttgaacgtac tttcccagta cacacaccaa aaatcgcgaa 1501441 aatcgaagtt gtacgttacg gtaaagtacg ccgtgctaaa ctttactacc tgcgtgaact 1501501 tcgcggaaaa gcggctcgta ttaaagagat cagacgataa tgataacgaa cgaaaagagc 1501561 ttgttacctg taacaagctc tttttttata cagaatttga aaatgccgga caggcatcgt 1501621 aaaatacata aaggacaaca atgaatcatg catactgaag ataaaggcgg tgttcgtgtc 1501681 acatgacaat tcaatggttc ccgggccata tggcaaaagc aagaagggaa gtaaccgaaa 1501741 aattaaaatt aatcgatatc gtatatgaat tggtagatgc cagaattcca atgtcatcaa 1501801 gaaacccaat gattgaagat attctaaaaa acaagccgcg aattatgctg ttaaacaagg 1501861 ctgacaaagc agatgcggca gttacacagc agtggaaaga gcactttgag aaccagggga 1501921 tccgctctct gtctattaat tctgtaaatg gacaagggtt aaatcaaatt gtgcctgcat 1501981 caaaagagat cctccaagaa aaatttgacc ggatgcgtgc gaaaggtgtg aagccgagag 1502041 cgattcgcgc tttgattatc ggcattccaa acgtcggaaa atcaacgctc atcaaccggc 1502101 ttgcaaagaa aaacatagca aaaacgggag acagacctgg tattacgact tctcaacagt 1502161 gggtcaaagt tgggaaagaa ttagagctat tagatacacc gggaattttg tggcctaaat 1502221 ttgaggatga gcttgtcggt ttgagactgg cagtcaccgg ggctattaaa gactcgatta 1502281 tcaatttgca ggacgtggcc gtgtttggtc ttcgttttct cgaagaacat tacccagaac 1502341 ggcttaaaga gcgttatggc cttgatgaga tcccagagga cattgccgag ctgtttgatg 1502401 caataggtga aaagcggggc tgtctcatga gcggtgggct catcaactac gataagacga 1502461 ctgaagtcat cattcgcgat attcgcactg aaaagttcgg caggctgtca tttgaacagc 1502521 cgacgatgta aaggcgcgca gaaatgcggg tctttatttt ttcttggctg aaccgataca 1502581 tacagtaagg gagaagagaa agtgaataca ttaaccgtaa aggacattaa agaccgtttg 1502641 caggaagtga aggatgcaca agacccattt attgcccaat gcgaaaacga cccgagaaaa 1502701 agcgttcaaa cgcttgtaga gcaatggctt aaaaagcaag cgaaagaaaa agcgctgaaa 1502761 gaacaatggg tgaatatgac ttcctatgaa aggctggcaa gaaacaaagg atttcgcttg 1502821 attgcaggtg ttgacgaggt cggccggggg ccattggcag gaccagttgt cgccagcgca 1502881 gtcatccttc cagaggaatg tgaaatactt gggctgacag actccaaaaa gctttcagag 1502941 aaaaaacgcg aggaatatta cgagcttatt atgaaggaag cactggcggt cgggatagga 1503001 attgtagaag ctactgtgat tgatgagatc aatatatatg aagcttcaaa aatggcaatg 1503061 gtgaaagcga tacaggattt gtcggataca cctgattatt tgcttgttga cgcaatgaca 1503121 cttccgctcg acacggctca ggcgtcaatt ataaaaggcg atgccaaaag cgtgtctatt 1503181 gcggcaggtg cgtgtatcgc aaaagtgacg agggaccgaa tgatgagcgc ttatgccgaa 1503241 acgtatccca tgtacggctt tgaaaaaaat aaaggctatg ggacaaaaga acatttggaa 1503301 gctctcgctg catacggccc aactgaattg caccgcaaaa ctttcgctcc tgttcaatct 1503361 ttcagataaa tcaccatgga caaggaggca cctttttaaa atgaacatac gaaatgatgt 1503421 gcaaaaggcg ctgcagcacc ttttcgggcg tacagccgtc ccgcaggaaa catcaaaagt 1503481 aaacgaagcg ctaaacgggg agaagcgtct cctcttagga aaagtgcttc gtttactagg 1503541 agatcagcat gccctgatcc aagtcggcaa tcaaactgtt cagggaaaac ttgaaactca 1503601 gcttcgtcct caggcatact attggttttc ctacgaaaaa aaaacggcag agcaaacagg 1503661 ccgtcttcag gtcgttcaaa gctttgatca aaatcctaaa accattcagg atgcagctgg 1503721 caaactttta aatgctattt cagtgaagac gtcaaacgca gctctcatga tgacaggagc 1503781 gatgctgaaa agcaaaacac ccgtaacaga aaatgatatc aaaacagctg tccgctggat 1503841 ggacacgctg ccttcgcaag acacaaaaaa agcagttgaa acggttctct tcgctttaaa 1503901 gcgtgatctt cccattcact ccgagatttt gaatggtgtt cacgctgtga aatcgcctgt 1503961 tccgttgcat cagcacgtat cccagctgct acaggcaatc gaccaaaacc ctcagcagag 1504021 ccaaatgatg tcaaagctaa aggaagcagt cacggtgctt ttaaatagtg aaatcgatgt 1504081 ccatgcagaa cggctgattg ataagcttat ttctttaacc gacaatacga aagcaccttc 1504141 tccgacgaat acagctggaa gcagggagct tagcacacca gctggctccc ccggaaaagc 1504201 cagcctgccg attgcaaatc acacagcaga acagggaagc atacaagaag agcctgttaa 1504261 aacagcagca gacattccaa ttaaagaagc ccgccagctg ctggtgaagc tgacggaatc 1504321 tgctgaaaaa aacagtctcc aaattgtgaa agaagcagca aattggatta aagcggctgc 1504381 ttcatcgggt gatagtaagt cacttgcagc ttcagctgtt ttacaggcgg cacaagtcac 1504441 agatcaggaa gccgaagtct ttttaaaggc tgttcagcag acagcacccc atttggcgga 1504501 taaggcagat gttctttctt tcttatccaa agtgaaaacg gcaatcggcg caagggacga 1504561 ggttgcgttc attaaagcgt ttgaacaagg aagcgcagtc acatctggcg aaatgcaatc 1504621 catcaagctg gctctttctg ccttaagagc atcgcatgag gtagccgaac cagtcaaaca 1504681 agaagccgat cagctttttc ataaattaaa tggccagctt ttcatgcagc aggaccatcc 1504741 atcatacagc caaattgtaa tgtcatttcc gatgttttcg aagtcagggg ttcaggacat 1504801 gactgttctg tttaaaggaa agaaagaagc ggatggaaag cttgatcctt cccattgccg 1504861 ccttttgttt ttgctgcagc ttgatacact aaaagaaacc gtcgttgatt gcttggtaca 1504921 gcaaaaagtc atgaccatta caatagagac tgatttcgag ctgcaggctg cgatcgatcc 1504981 gatggtgccc gcgcttaaac aggggctaaa ggaaatgggg tacagccttt caggggtaaa 1505041 cgctaaaaaa agggttcaca ccgaagaaaa ggcttcaatc gatcaatata taacaagtat 1505101 cagtgatcag gaagtggatg tgaaaatatg aaagagcaga caccgatcag aaaagctgtt 1505161 gctctccatt atgacgaaca aaaagacaag gcgccgagag tgattgccac agggaagggc 1505221 catgtagctg acaacattat aaaagaagcg aaaaaagcag gggtcccgat tcaagaagat 1505281 cggacccttg tcgaattaat gcgccatttg acggtagatg atcaaattcc tgaagctctt 1505341 tatgaaacgg tagccgagat tttttcattc atttacaaat tggacgaaag cgtaaaaaac 1505401 aaaaaatagc taaaatattc cccatccttc tttgaaattt atgtttttaa taaagtaaaa 1505461 gtttgaatgt ttagaaggat taaaagattt tgcatcgaac tgtagacaat tcttccagta 1505521 ttattataga atgaaagcgc agtctatttt agttttgtta cataagttag gaggatggga 1505581 aatgaatatc catgagtacc agggaaaaga agtcctcaga aaatatgggg tatctgttcc 1505641 tgaaggtaaa gtggctttta cagcagaaga agcagttgag agtgcaaaga gcttatccag 1505701 ctcggtttat gtcgtaaagg ctcaaattca tgctggcggt cgaggcaaag ctggtggggt 1505761 aaaaatagca aaatcattag acgaagtaaa agcgtatgcc gaagaactat tagggaagac 1505821 cctagttaca catcagacgg gtccggacgg ccaagtaata aaacgcttac ttattgaaga 1505881 aggctgcgat attaaaaaag aatattacat cggtctagtg cttgaccgcg ccacttcaag 1505941 aatcgtttta atggcttctg aagaaggcgg aacggaaatt gaagaggttg cggagaaaac 1506001 accagaaaaa atcaaaaaag ctgtcattga tccagctgtt ggccttcaag gctatcaagc 1506061 cagagaaatt gcattcgcta ttaatattcc aaaagagctc gtgggaaaag ctgctaaatt 1506121 tatgcttgga ctatataaag cgtttgttga gaaagactgc tcaatcgccg aaatcaatcc 1506181 gcttgttgtg actggcgacg gaaatgtgat ggcgcttgat gcaaaattga attttgacag 1506241 caatgcgttg taccgacaaa aggacattat ggaatacaga gatttggatg aagaagatcc 1506301 gaaagaaatt gaagcgtcca aatatgatct aagctacatt tcccttgatg gaaatatcgg 1506361 ctgtatggta aacggcgcgg gacttgcaat gtctacgatg gatattatca agcattatgg 1506421 aggagaaccg gccaacttcc ttgatgtggg cggcggtgca accgcggaaa aagtcacgga 1506481 agcatttaaa atcattcttt ctgatcaaaa cgttaaaggg atttttgtca acattttcgg 1506541 cggcattatg aaatgtgatg tcatcgcaga aggggttgtt gaagcgacta gacaagttgg 1506601 tttgacattg ccgcttgtcg tccgtcttga aggcacaaac gtggatctag ggaagaaaat 1506661 ccttagtgaa tcaggattaa acattacatc tgcggaatca atggctgacg gcgcgcagaa 1506721 aatcgtatcc ttagtttaag aaagaatgaa aggcagggga ccaaataatg agtgttttca 1506781 ttaataaaga tacaagagtt attgtgcaag ggattacagg ttctaccgct ttatttcata 1506841 cgaagcagat gcttgaatac ggcacaaata tcgttggcgg tgtaacacct ggaaaaggcg 1506901 gaacagaagc ggaaggtgtt cctgtattta atacagtggc tgaagcagtt caaacaaccg 1506961 gcgctaacgc gtctgttata tatgtgcccg caccgtttgc agctgatgcg attatggaag 1507021 cggtagatgc ggagcttgat ctcgtgattt gtatcacaga acatatcccg gttttggata 1507081 tggtgaaggt caaacgcttc atggaaggca agaaaacgag actgataggg ccgaactgtc 1507141 ctggtgtcat tacgcctgaa gaatgtaaaa tcggcattat gcccggatac atccataaaa 1507201 agggtcatgt aggcgttgta tcacgttcag gaacattaac atacgaagcg gtgcaccagc 1507261 tctcagaagc gggtgtaggg caatctacag ctgttggaat cggcggcgac cctgtaaatg 1507321 gaacaaactt tattgacgtt ttaaaagcgt ttaacgaaga tcctgacaca cacgcagtca 1507381 tcatgattgg cgaaatcggc ggtacggccg aagaggaagc ggcagagtgg gtaaaagcca 1507441 acatgacaaa accggtagtc ggttttattg gcggtaaaac agcacctcct gggaagcgca 1507501 tggggcatgc aggcgccatt atttccggcg ggaaagggac agctgatgaa aaaatcaaaa 1507561 cccttaatgc atgcggaatc gaagttgcag agacaccttc tgtcatgggt gaaaccttaa 1507621 tcaaggtgct gaaagagaag aacttgttcg aaacttgtaa aacgcattaa taaaaaaggg 1507681 acagccgtca aggctgttcc tgctttttct aacaaaagga ggtcaatcta ttggatcagg 1507741 ccgctgtctg cctaacgatt tgcagaatca atcaattatt atccccatcc cttctattaa 1507801 aatggtggaa agccgatccg tctatgtcgc tgacatcacc cgtgttacaa acggttactc 1507861 gtgatcaaat aaaagcagct gcattaaaaa acgaaataga acaattttat ccaaagctcc 1507921 cgcgtgtact tgctgcttat cgtgagcaag gcattaacac catccctatt tcttcaaagc 1507981 aatatccttt ctggcttaaa agcatttatg atccccctgc cgtactgttt gcaaaaggtg 1508041 atatgactct tctttcgaaa gggagaaaaa ttggaattgt aggcacaaga aatccaacag 1508101 cttatgggaa acaagttgtc aatcatctta caaaagagat ctgtcgtaaa ggttgggtga 1508161 ttgtcagcgg actggcgtct gggatagacg gaatgtccca tgctgcaagt attaaggcga 1508221 aggggcggac aattggcgtc attgcaggcg gatttcaaca catttatccc cgagaaaacc 1508281 ttcagttagc agatcacatg gctaaacacc atatcctgct gtcagagcac ccacctgaaa 1508341 ctaaacccca aaaatggcat ttccctatga gaaaccgtat tatcagcgga ctaagtgaag 1508401 gcgttattgt cgttcagggc aaagaaaaaa gcggttcgct gattactgcc tatcaagcat 1508461 tggaacaagg gagagaggta tttgccgtac ccggttcatt gtttgaccct tacgccggag 1508521 gtcctataaa actgatccag cagggggcta aagccatatg gtcagcagag gatattttcg 1508581 aggaacttcc tgagagaaac gttcaatata cggaaccctt ttgaattatc gtttgacaaa 1508641 cggtattgta atatttaata atagtgagga tttaaagttg catattgttt tctatttaat 1508701 taatgacgtt catgataaag aatgaaatgt tgaaagccaa ataaagacag ctgcaaaaat 1508761 aaaattgaaa tatcttgaaa agagagagaa cacctcttga gggggatgaa aatgtctgat 1508821 tatctagtca tcgtggaatc gcccgctaag gcgaaaacga ttgaacgtta cttaggtaaa 1508881 aaatataaag taaaagcatc aatgggacat gtccgggatc ttccaaaaag tcaaatggga 1508941 gttgacatag aacagaattt tgaaccgaaa tatattacca ttcgaggtaa aggcccggta 1509001 ttaaaagagc tgaaaacggc tgcgaaaaaa gccaaaaaag tgtatctcgc agctgacccc 1509061 gacagagaag gggaagcgat tgcatggcat ttggcacaca gtcttgattt agatctcaac 1509121 tcagactgcc gtgtggtgtt taacgaaatt acaaaagacg ctattaagga atcgtttaag 1509181 catccccgca tgatcaatat ggatttagtg gatgcacagc aagcgagacg tattttagac 1509241 aggcttgtcg gatataaaat cagtccaatc ttatggaaaa aagtcaaaaa agggcttagc 1509301 gcaggacgcg tgcaatccgt tgccctccgt ttgattattg accgtgaaaa agagattaac 1509361 gactttaagc ctgaggaata ttggacaatt gacggtacgt tcttaaaagg tcaagaaacc 1509421 tttgaagcga gctttttcgg gaaaaacggc aaaaaacttc ctttaaatag tgaagctgat 1509481 gtaaaagaga ttctttctca gctcaaaggg aatcaatata cagttgaaaa agtaaccaaa 1509541 aaggaacgca aacgtaatcc tgctttgcct tttaccactt ctaccctgca gcaggaagcg 1509601 gctcgcaagc tcaatttcag agcgaagaaa acgatgatga ttgcacagca attatatgaa 1509661 ggaattgatt taggaagaga aggaacggtt ggtctgatca cgtatatgag aacggattca 1509721 acccgtattt caaatacggc tgttgatgaa gcagctgcat ttattgatca gacatatgga 1509781 aaagagttcc taggcggaaa acggaagcct gcgaaaaaga atgaaaatgc ccaggatgcc 1509841 cacgaagcaa ttcggccgac atcagttctt agaaaaccaa gtgaattaaa agcagtcctc 1509901 ggcagagacc aaatgagact gtataaatta atttgggagc gttttgttgc cagccaaatg 1509961 gcaccggctg ttctcgatac aatgagtgtc gacctgacaa acaacggttt gacatttcgt 1510021 gcaaatggaa gtaaagtcaa gttttccggg tttatgaagg tgtatgttga aggaaaagac 1510081 gatcaaatgg aagaaaaaga ccggatgctg cctgacttac aagaaggcga cacggtatta 1510141 tcaaaagata tagaacctga gcagcatttt acccagccgc ctccgcgata tactgaggcc 1510201 cggcttgtta aaacccttga agaacgcggt atcggccgtc catccacata tgctccgaca 1510261 cttgatacta ttcagcggcg cggctacgtg gcattggata ataaacgttt cgttccgact 1510321 gaattaggtc agatcgttct tgacttgatc atggagtttt tccctgagat cattaacgtt 1510381 gagtttacag ctaaaatgga gagagatctt gatcatgttg aagaaggaaa taccgaatgg 1510441 gtcaagatta tcgataattt ctacaccgat tttgaaaaac gcgtcaaaaa agccgaatcg 1510501 gaaatgaagg aagttgagat tgaaccagag tatgctggag aggattgtga attgtgcagt 1510561 tctccaatgg tatataaaat gggacggtac ggtaaattct tagcttgctc caacttccct 1510621 gactgccgga acacgaaacc gattgtgaaa caaatcggtg tgaagtgccc gagctgcgga 1510681 gaaggaaaca ttgttgagcg aaaatcgaaa aagaaacggg tgttttacgg ctgtgaccgt 1510741 tatccggact gtgaattcgt atcatgggac aaaccaattg aacgaaaatg cccgaaatgc 1510801 ggaaaaatgc tcgtcgagaa aaaactcaaa aaaggtatac aagtccaatg cgtggaatgc 1510861 gattataagg aagaaccaca gaagtagcgg tgagcagggt cttgctcacc ttctttgtgt 1510921 gttaaaagaa ggccttgaat aataaactag gagatgtgaa agatgaacca acaaacagtg 1510981 aatgtaatcg gagccggact cgcaggaagt gaagcagcat ggcagcttgc caaacgtggg 1511041 attcaagtca aattgtatga aatgcggcca gttaaacaaa cgcctgcgca tcatacagat 1511101 aaatttgctg agcttgtctg cagcaactct cttcgctcta atacacttgc taacgctgtc 1511161 ggtgtattaa aggaagaaat gcgtgcgctt gattcagcca ttatcgctgc ggctgacgaa 1511221 tgttcggtgc ctgccggggg cgctcttgca gtagaccgtc atgaatttgc cgcaagtgtg 1511281 acaaatcggg tgaaaaatca tccaaacgta accgttatta atgaagaagt gactgaaatt 1511341 cctgaaggcc ctactatcat cgcaacgggt ccgttaacat ctgaatcgct gtctgcccag 1511401 ctgaaggagc tgactggaga ggactattta tatttttatg acgcagcggc gccaattgta 1511461 gaaaaagaca gccttgatat ggataaagtg tacctgaaat cccgttatga taaaggtgaa 1511521 gcagcatatt tgaactgccc gatgacagaa gaagagtttg accgttttca tgaagcatta 1511581 acatcagcag aaacagtgcc gttaaaagaa tttgaaaaag agattttctt tgaaggctgc 1511641 atgccgattg aagtcatggc aaaacggggt aagaaaacaa tgcttttcgg tccgatgaaa 1511701 ccagttggtc tagagcatcc tgttacagga aaacgccctt atgccgtcgt tcagctcaga 1511761 caggatgatg ctgcgggaac actttataat attgtaggat tccagacaca tttaaaatgg 1511821 ggagaccaaa aggaagttct caagttgatt ccaggacttg aaaatgtaga aatcgtcaga 1511881 tatggcgtga tgcatagaaa cacatttatt aactctccaa gcctgttaaa gccgacttat 1511941 caatttaaaa accgcagtga tctgttcttt gcaggccaaa tgacgggagt agaaggatat 1512001 gtggaatcag ctgcctcagg acttgtagca ggcattaatg cggcgaagct tgtattggga 1512061 gaagagcttg tgatcttccc tcaggaaaca gcaattggca gtatggcaca ttatattaca 1512121 acaacaaacc agaagaactt ccagccgatg aatgcaaact ttgggctttt gaaagaattg 1512181 ccagttaaaa ttaaaaataa aaaagaacga aatgaacaat acgcgaaccg tgcgattgaa 1512241 acaattcaaa caatttcgaa aacaatatag gtattgattg caacctgagc gcgatttgtg 1512301 ataccattta aaagcccttc ctggggaggt attaggcatg gagaatgtta agaatttcgt 1512361 aaagttattc gttgaatatt tacaaattga aaaaaattat tcacaatata ctattgtgaa 1512421 ttatgtggat tcaattgaag aattcgagac tttcctgcgc gttcaaggta taaatggatt 1512481 tgaagaagct gcatatcaag atactaggat ttttttgaca gaagcctatg aaaaaggttt 1512541 atcgagaaga acaataagca aaaagatatc tgcattaaga agcttttata agtttctgat 1512601 gcgggaaaag cttattgaag aaaatccgtt tcagcttgtt catctgccaa aacaggagaa 1512661 acggataccg aagtttctat atcaaaaaga gcttgaggag ctgtttgaag tttcagatat 1512721 aagccagccg gccggaatga gggatcaagc gctgttagag ctgctctatg ccactggaat 1512781 gagggtcagt gaatgctgtt ccataactat taacgacgtt gatttattta tggacactgt 1512841 gcttgttcac ggtaaaggca agaagcagcg ctatatcccc tttgggtctt atgcccgcga 1512901 agcgttgaag gtatacatga atagcggaag acagtgcttg ctgatgaagg caaaagaacc 1512961 tcatgatcta ttattcgtaa atcaaagagg cggaccgctt acagcccgtg gcatcagaca 1513021 tattttaagc gggcttgttc aaaaagcgtc aagcacttta catatccatc cgcatatgct 1513081 tcgacatacg ttcgccacgc atctgttaaa tgaaggagcg gatttgagaa gcgttcaaga 1513141 actgctcggg cattccaatc tgtcttctac acagatatac acgcacgttt cgaaggaaat 1513201 gttgagaaac acatatatgt ctcaccatcc aagagcattt aagaaaaatt aaaggaggcc 1513261 ctttatgtca tcttttcatg cgaccacaat atttgccgta cagcataaag gacgaagcgc 1513321 tatgtccgga gacggccaag taacatttgg tcaggctgtt gtcatgaaac acacggcacg 1513381 gaaagtgaga aaactgttta acggcaaagt tcttgctggt tttgcgggat ctgttgcaga 1513441 cgctttcact ttattcgaaa agtttgaagc taagcttgaa gaatataacg gcaacttaaa 1513501 acgggcggct gttgagcttg caaaggaatg gcgcagtgat aaagtgctaa gaaagctcga 1513561 agccatgctg attgttatga atcaggatac tttgcttctc gtatcgggaa caggcgaggt 1513621 gatcgaacca gatgacggca ttctcgcgat tggatcagga ggcaattacg ctttggcagc 1513681 gggaagagca ctgaaaaagc atgccgggga aagcatgtct gcaagtgaga ttgccagagc 1513741 cgcgttagaa acagcaggcg aaatttgtgt ttacacgaac gatcaaatca tactggaaga 1513801 gcttgaatag aaaggacttg aggcgcatgg aaaaaaaacc gttaactcct agacagattg 1513861 tagatcggtt agaccaatat attgtcggtc agcaaaatgc gaaaaaagct gtcgccgtgg 1513921 cattaagaaa ccgctataga agaagtcttc tggatgaaaa gctgaaggac gaggtcgttc 1513981 cgaaaaacat tttaatgatg ggtcctaccg gcgtcgggaa aactgaaatt gccagacgaa 1514041 tcgctaagct ttcaggtgcg ccatttatca aaattgaagc tactaaattt accgaagtcg 1514101 gctatgtagg cagagatgtt gaatcaatgg tcagagatct tgtggagact tctgttcggc 1514161 ttataaaaga agagaaaatg aatgaagtaa aggaacaggc agaagaaaat gcaaacaaac 1514221 gcattgttcg tctgttagtt cctgggaaga aaaaacaatc tggtgttaaa aatccgtttg 1514281 aaatgttttt tggaggcagc cagccgaatg gtgaagatga ggcggagagc caggaagaag 1514341 caaacatcga agaaaaaaga aaacgaatgg cgcatcagct ggctttagga gagctcgaag 1514401 actactatgt aacagtagaa gtcgaagaac agcagccttc tatgtttgac atgctgcagg 1514461 gctcgggtat ggagcagatg ggtatgaaca tgcaggatgc gctgagcgga ttaatgccaa 1514521 agaaaaagaa gcggcgcaaa atgacagtca gagaagccag aaaagtcctg acgaatgaag 1514581 aagcaagcaa actcatcgat atggatgaag tcggccagga agctgttcag agagcagaag 1514641 agagcgggat tatctttatc gatgagattg ataaaatcgc aaagaacggc ggtgcatctt 1514701 cttctgccga tgtttcaaga gaaggtgttc agcgggatat ccttccgatt gttgaaggtt 1514761 ctaccgttgt cacaaaatat ggttctgtaa aaacagacca tgtattattt attgcagcag 1514821 gagcgtttca tatggccaaa ccgtctgatt tgattcctga gctgcagggg cgtttcccga 1514881 ttcgtgtaga actgaacaaa ctcacggtag acgacttcgt gagaattttg gttgagccgg 1514941 ataatgcgct gctgaaacaa tatcaggcat tattgcagac agaaggtata tctcttgaat 1515001 tttctgacga agctattcat aagattgctg aagttgctta tcatgtgaac caggacacag 1515061 ataatatcgg tgcgagacgc cttcatacaa tacttgaacg cctattagaa gatttgtcgt 1515121 ttgaagctcc agatgtaacg atggagaaaa taacgattac accacagtat gtcgaagaaa 1515181 agctcggaac gatagccaaa aacaaagatt taagtcaatt tatattgtga aaaatttaat 1515241 atgaggaatg tttaggagga ttatttatca tggctttatt acaaaaaaca agaattatta 1515301 actccatgct gcaagctgcg gcagggaaac cggtaaactt caaggaaatg gcggagacgc 1515361 tgcgggatgt aattgattcc aatattttcg ttgtaagccg cagagggaaa ctccttgggt 1515421 attcaattaa ccagcaaatt gaaaatgatc gtatgaaaaa aatgcttgag gatcgtcaat 1515481 tccctgaaga atatacgaaa aatctgttta atgtccctga aacatcttct aacttggata 1515541 ttaatagtga atatactgct ttccctgttg agaacagaga cctgtttcaa gctggtttaa 1515601 caacaattgt gccgatcatc ggaggcgggg aaagattagg aacacttatt ctttcgcgtt 1515661 tacaagatca attcaatgac gatgacttaa ttctagctga atacggcgca acagttgtcg 1515721 gaatggaaat cctaagagaa aaagcagaag aaattgaaga ggaagcaaga agcaaagctg 1515781 tcgtacaaat ggctatcagc tcgctttctt acagtgagct tgaagcaatt gagcacattt 1515841 ttgaggagct tgacggaaat gaaggtcttc ttgttgcaag taaaattgct gaccgtgtcg 1515901 gcattacccg ttctgttatt gtgaacgcac tcagaaagct ggagagcgcc ggtgttatcg 1515961 agtctagatc attaggaatg aaaggtactt atatcaaggt actaaacaac aaattcctaa 1516021 ttgaattaga aaatctaaaa tctcattaat cacaaaaaga accctttttg agggttcttt 1516081 ttttatttca aataaaggaa atcaataagc tttatttcct gggttgaaag tctttctatg 1516141 taataatttt aataaatttt gcatttttct tcaaaaagtt tcaaaaatgc cgaaaagaaa 1516201 ggagaaaaaa cagaaattct gctattttca ggcttatatc aaggcgagaa atgtagttct 1516261 aacaatctag gactttatac ctagttgcaa aatagataat tgtgaggaca tttttttaca 1516321 cgaacttcat agactttatg cctgttattt cttacaataa gcatatagtt ttacaattct 1516381 cgacaaggat attgagggtg aaaaaaactg aaatggaggt aagtggattt gagcttattt 1516441 tctggaacga tacaaaatct tgaaaatgcc ttgagcagag cggatattaa gcaaaaagtc 1516501 ataactaata atatcgccaa tatagataca ccgaactata aggcaaaaaa agtctctttc 1516561 caaaatttat tagatcaaga atcctcgcgt cttgaagcga taaaaacaga ctatcgtcat 1516621 gttgattttt ctgatactga ttcgaattat tcaattgttg cgagcggaga tacatcgtat 1516681 cagcaaaacg gaaacaatgt tgatgttgac aaagagatga cagaattggc gcaaaatcaa 1516741 atcaactatc aagctttggt tgaaagaatg aacggtaaat ttaattcgct gaagaccgta 1516801 ttaacaggag gaaaatgatg acagcttttc atagcttaaa tgtttcagca tcggctttaa 1516861 cagctcagcg agtcagaatg gacgttgtat catctaactt agcaaatatg gatacgacaa 1516921 gagctaagca ggtgaatgga gagtgggtgc cttacagaag aaaaatggtt tcccttcagt 1516981 caaaaggtga atcgttctct tccattctca attctcaaat gagcggaagc gggaatgctg 1517041 gaaacggtgt gaaggtttca aaaattacgg aggatgattc ggattttaat cttgtctatg 1517101 atccgacaga ccctgatgca aacgctgaag gatatgtaca aaagcctaat gttgatccat 1517161 taaaggaaat ggttgatctt gtcagcagca ctagatcata cgaggcgaat gtcacggcga 1517221 tgaatgccac aaagggaatg ctgatgaagg cgttagaaat cggaaagtag gcgaactgtt 1517281 aaacaaggtg aaaaaacgat ttaattaagg tattaggggg ataacaatgc aatccttgaa 1517341 ttatgaagat caggtgcttt ggacgcgctg gaaagagtgg aaagatccta aagccggtga 1517401 cgacttaatg cgccgttaca tgccgcttgt cacatatcat gtaggcagaa tttctgtcgg 1517461 actgccgaaa tcagtgcata aagacgatct tatgagcctt ggtatgcttg gtttatatga 1517521 tgcccttgaa aaatttgacc ccagccggga cttaaaattt gatacctacg cctcgtttag 1517581 aattcgcggc gcaatcatag acgggcttcg taaagaagat tggctgccca gaacctcgcg 1517641 cgaaaaaaca aaaaaggttg aagcagcaat tgaaaagctt gaacagcggt atcttcggaa 1517701 tgtatcgccc gcggaaattg cagaggaact cggaatgacg gtacaggatg tcgtgtcaac 1517761 aatgaatgaa ggtttttttg caaatctgct gtcaattgat gaaaagctcc atgatcaaga 1517821 tgacggggaa aacattcaag tcatgatcag agatgacaaa aatgttccgc ctgaagaaaa 1517881 gattatgaag gatgaactga ttgcacagct tgcggaaaaa attcacgaac tctctgaaaa 1517941 agaacagctg gttgtcagtt tgttctacaa agaggagttg acactgacag aaatcggaca 1518001 agtattaaat ctttctacgt cccgcatatc tcagatccat tcaaaggcat tatttaaatt 1518061 aaagaatctg ctggaaaaag tgatacaata atgaatttca tggttagcga gtgaaaaaca 1518121 tgtcaacact attatggctt ttaagcttta tgctccacgg cgttcttctg tacgctgtca 1518181 ttatcctgta tacgaggctc gctgcagtga aagaaacaga aaaacagcaa aaacagatac 1518241 ttgaagagac ggaaaacacc ttggcggcat ttctgcttga attaaaagaa gaaaatgaga 1518301 aactgataga aaataaagct tcatctgcaa gtcaatcaga tgaagaatcc caaaagtcag 1518361 gccttcagac ctctgaaaca tatcaagagc gggatccagt ccaagaggca gagaatcttc 1518421 ctgaacatat tgaaggtctg attacagagg ttgaccgtcg ggaagagctc gtaaacagtg 1518481 aggtccaatc atttgaagac caggtcatag aattatatga acagggatat tcggcaagtc 1518541 aaattgccca gaaaatgaag agcggaaaga cagaaatcga gctattttta aaatttcgct 1518601 ccaaaggtgt aaaggattct tgattgtcgg ataaagctgt gttatattat gtcttggtgt 1518661 taaatacaca cgcttaacga tttatgcaga gggtgctgca ggcggcagtt ctgtacaaaa 1518721 atgacctaag cggaggaaaa aaaccattat attaggagga aataacatgt cagtcatttc 1518781 tatgaagcaa ttgcttgaag ctggtgttca cttcggtcac caaacacgcc gttggaaccc 1518841 aaaaatgaag cgttacattt tcacggagcg taacggaatc tacatcattg accttcaaaa 1518901 aacagtcaaa aaagtagagg aagcttacaa cttcactaaa aatcttgctg ctgaaggcgg 1518961 aaaaatcctt ttcgtcggaa caaaaaaaca agctcaagat tctgttaaag aagaagctca 1519021 acgctctggc atgtactatg tcaaccaacg ctggttgggc ggtacattaa caaacttcga 1519081 aacaatccaa aaacgtatta aacgtcttaa agacattgaa aaaatgcaag aaaacggtac 1519141 gtttgatgta cttcctaaaa aagaagtcgt tcaattgaaa aaagaattag agcgtcttga 1519201 aaaattccta ggcggaatta aagatatgaa ggatcttcct gatgcattat tcatcatcga 1519261 tcctcgcaaa gagcgcatcg ctgttgcgga agctcgcaaa ttaaacatcc ctatcatcgg 1519321 tatcgtagat actaactgtg atccagatga aatcgatgtt gttatcccag cgaacgatga 1519381 cgctatccgc gctgttaaac ttctaacttc taaaatggca gatgcaatct tagaagcgaa 1519441 gcaaggcgaa gaagaagcgg aagttgctga agaaactgca ccagaaacag aaacaacaac 1519501 tgcgtaacct attcaaaagg tgataagagg gactgccttt tatcaccttt tttcaagaaa 1519561 aatgtgtaat atacatactc ttgtttaaac atataaggag gaatacaaat ggcaattact 1519621 gcacagcaag taaaagaact gcgtgaaaaa actggcgcgg gcatgatgga ttgtaaaaaa 1519681 gcgttaactg aaactgacgg agatatggac aaagcaattg accttttaag agaaaaagga 1519741 attgcaaaag cagcgaaaaa agctgaccgt atcgcagcag aaggttctac tcttattaaa 1519801 actgacggca acaaaggcgt tatcctagaa gtaaactctg aaactgattt cgttgcgaaa 1519861 aacgaaggtt ttaaagagct tcttaacact ttagctgacc accttcttgc aaacacgcca 1519921 gctgatgttg aagaagcaat gggccaaaaa atggaaaatg gctcaactgt tgaagagtac 1519981 atcacaagcg cagttgctaa aatcggtgag aaaatcactc ttcgccgctt tacagttctt 1520041 acaaaagacg acagctctgc attcggtgcg taccttcaca tgggcggccg catcggtgta 1520101 ttaactgttc tcaacggtac aactgatgaa gaaactgcga aagatatcgc aatgcacgtt 1520161 gctgcagtta accctcgtta catttctcgt gatcaagtat ctgaagaaga aacaaatcat 1520221 gagcgtcaaa tcttaactca gcaagccctc caagaaggca aacctgaaaa catcgtagcg 1520281 aaaatggttg aaggccgtct gaacaaattc ttcgaagaaa tttgtctatt agaccaagcg 1520341 ttcgttaaaa acccagatga aaaagtgaaa caagttattg cagcgaaaaa cgctactgtt 1520401 caaacttttg tccgctatga agttggagaa ggcatcgaaa aacgtcaaga aaactttgct 1520461 gaagaagtaa tgaaccaagt gaaaaaataa tggtgaaaag atttcgcggc taagtcgcgt 1520521 cttttcaggc agtatagggg acacattttg tgttccctat ttttaaaact atatttacaa 1520581 accttttttt ctcttgcata atagaaaacg gcaatgttta cacttggagg ttatcatgga 1520641 aaaaccaaaa tacaaacgta tcgtattaaa gcttagcggg gaagcattgg caggagaaca 1520701 gggaaatgga attaacccga ctgtcattca atccattgca aagcaagtga aggaaatcgc 1520761 tgagcttgaa gtcgaagtgg ctgttgttgt aggcggcggc aacttatggc gcggaaaaac 1520821 aggaagtgac ctgggcatgg accgcgcgac tgctgactat atgggaatgc tggcgacagt 1520881 aatgaattcg cttgctcttc aagacagctt ggaaacactc ggaatccagt ccagagtgca 1520941 aacatccatt gaaatgagac aagttgctga accgtacata agaagaaaag cgatacgcca 1521001 cttagagaaa aaacgtgtcg ttattttcgc tgcgggcaca ggaaacccat atttctcaac 1521061 tgatacgaca gctgcactgc gggctgctga aattgaggca gacgttattt taatggctaa 1521121 aaataacgtt gacggtgtgt ataatgctga tcctagaaaa gatgaatcag ctgttaagta 1521181 tgaatcactt tcttatcttg acgttcttaa agacggcctg gaagtcatgg attcaacagc 1521241 ttcctcttta tgcatggaca atgacattcc gcttatcgtc ttttctatta tggaagaagg 1521301 aaatatcaaa cgtgccgtta tcggtgaatc aatcggaacg atcgtgaggg ggaaataacg 1521361 tgtcaaaaga agtattaact caaacaaaag aaaaaatgga aaaagcaatt gctgcttatc 1521421 agcgcgaatt ggctactgta cgcgcaggcc gtgcaaatcc atcattatta gataaagtaa 1521481 cggttgaata ttacggagcg cagacacctt taaatcagtt gtcttctatt aacgtgcctg 1521541 aagctcgtat gctcgttatc acgccatacg ataaaacagc aatcggtgat atcgaaaaag 1521601 cgattttaaa agctgattta ggtcttacac caacaagtga cggcaatatg attcgaattg 1521661 caattccggc actaacagaa gagagacgga aagaattagt gaaagttgta aaaaaatatg 1521721 ctgaagaagc aaaagtagct gttcgtaacg ttcgccgtga tgctaacgat gatctcaaaa 1521781 aacttgagaa aaacggagac attactgagg atgaactgcg tgcttccact gaagacgttc 1521841 aaaaactgac agatgaatat gtgtcaaaaa ttgacagtgt cacaaaagac aaagaaaaag 1521901 aaatcatgga agtttaatga aaaactatgt acaatagata atagtgaaaa gaccctctca 1521961 tgtttacagg gggttttttt gttaatactg ttgattacat tgattatcag cagggaatgt 1522021 aacctttttg ggtgacggag gaatctcatg ctcaacatac tcaaaaattg gaagaatcag 1522081 caaactgcgg cttccaactt agaacgttat acaaaagaag acatacttaa gggagaaatt 1522141 cccgaacaca tcgccattat catggatgga aatggccgtt gggctaaaaa acgctctctt 1522201 cccagaattg caggccacca tgaagggatg aaggtggtaa aaaggaccac gaagctcgca 1522261 aacgaattag gtgtcaaagt actgacattg tatgcatttt caacagaaaa ctggaaaaga 1522321 ccgaaaatgg aggtcgattt tttaatgaag cttccggaag aatttttgaa tacgtatctt 1522381 ccagagcttg ttgaggaaaa tgtacaggtt cggatcattg gggatgaaac ggctttgccg 1522441 gcgcacacat tacgtgcgat tgaaaaagct gtacaggaca cggcgcaaaa cgacggaatg 1522501 atccttaatt ttgctcttaa ctatggaggc cgtactgaaa ttgtcagtgc tgcaaaatca 1522561 ctcgcggaaa aagtgaagga aggctctttg aatattgaag acattgatga atcgcttttt 1522621 tctacttatt tgatgactga atctttgcag gatcctgaac ttttaattcg aacgagcggc 1522681 gagataaggc tgagtaattt tatgctatgg caggttgcct acagtgaatt tgtctttact 1522741 gacgtcttgt ggcctgactt taaagaagat cacttcttgc aggcgttagg agagtttcag 1522801 cagagaggcc ggaggtttgg cggaatttag aggatggtgg acatgaaaca aagaattttg 1522861 acaggtgttc tggcagcaat tgtattttta tttttggtta ttgtcgggaa attgccgttc 1522921 accatattaa tttatgctat gggcagtgtg gcgctttttg aacttttacg gatgaaaaag 1522981 ctgaagctgg tttcactgcc gggtttgatc ggtcttttat tattgtggat gttcttatta 1523041 ccaagccagt attcgttttt tgaagcggac gggatttcca aaatggaaat cgctttattt 1523101 gcggtactgc tattgctgac ttacacagtg ttggtcaaga acacctttac ttttgatgaa 1523161 gtcgggttta ttacgcttgc agcaatttac atcggaatgt gttttcatta ttttatcgaa 1523221 atcagaaatc ttgaccaata cggattaaca tacatttttt atgcgtgtgt tgtcatttgg 1523281 tccaccgatt ccggtgccta ttttgtcggt aaatcgcttg ggaagcggaa actgtggcct 1523341 gaaatcagtc cgaataaaac agtggaaggg tttgcaggcg gaattgtcat cgcacttgta 1523401 ttggcgacga tttttcagct tgttgcacaa cttccgatcc cgtatatcta tctgctgttg 1523461 atcacgctgt ttttgtctgt ttttggacaa ctgggagatt tagtggaatc cgccttgaaa 1523521 agacattacg atgtaaagga ttctgggaat attcttcccg ggcatggcgg tatattagac 1523581 cgttttgaca gtttcttgtt tgtcatgcct ttcttgtact ttctgcttgc ccttttttca 1523641 taaaaaagtc taatatgaat atgagactga tcatgcagca ataagaatag gagtagtggc 1523701 aactttgaaa aatatttgtc ttttaggagc aacaggatca atcggcgaac agactcttga 1523761 tgtactgcgt gcacatcaag accaatttca gctggtatct atgtcgtttg gcagaaatat 1523821 tgataaggcc gttccaatga ttgaggtctt tcagccgaag tttgtctctg tcggtgatct 1523881 ggatacatat cataaattaa aacaaatgtc tttttctttt gaatgccaaa tcgggctggg 1523941 agaagaagga ctgatagaag cagcagtgat ggaggaggtt gacattgttg tcaacgcttt 1524001 gcttggaagc gtcggtctta tcccgacatt aaaggcaatt gaacagaaaa aaacaattgc 1524061 gcttgcaaat aaggaaactc ttgtcactgc agggcatata gtaaaagaac atgctaagaa 1524121 atatgatgtt ccgctgctgc ctgttgacag tgagcattca gccatttttc aagctcttca 1524181 aggcgaacag gctaaaaaca ttgaacgcct catcattacg gcatccggcg gaagttttcg 1524241 ggacaagacg cgggaggagc tcgaatcagt aacggttgaa gatgcattaa aacatccaaa 1524301 ctggtcaatg ggtgcaaaaa ttacaattga ttcggctaca atgatgaata agggattaga 1524361 ggtgatcgag gcacactggc ttttcgatat accttatgaa caaattgatg tggttttaca 1524421 taaggagagc atcatccatt caatggttga gttccatgat aaaagtgtga tcgcacagct 1524481 cggaactccg gatatgagag tccccattca atatgcgctc acttatcctg accgattgcc 1524541 attaccagat gcgaaaaggc ttgaattatg ggaaatcggc agccttcatt ttgagaaagc 1524601 tgattttgac aggttccgat gcttacaatt tgcttttgaa tcaggtaaaa taggaggaac 1524661 aatgccgaca gtgctaaatg cggcaaacga agtagctgtc gctgcctttt tagctggcaa 1524721 gataccgttt ttggctattg aagactgtat cgaaaaggca ctaacccgcc atcaattact 1524781 gaaaaaaccg agcctggcgg acattcaaga agtggacaaa gatacccggg gatacgtcaa 1524841 ttcaatactc acataaggtg gtatgttcgt gaatacagtt atagcgttta tcattatttt 1524901 cggaacgctc gttttcttcc atgaactggg ccatttattg ctagcccaaa gagcgggaat 1524961 tctctgccgt gaatttgcga tcggcttcgg tccaaagatt ttttctttca aaaaaaatga 1525021 aacagtttat acgatcaggc tgcttccggt cggcggattt gttcgtatgg ccggcgaaga 1525081 tccggaaatg attgaggtga aacccggata cacggtcggg cttctgttta ataaggaaga 1525141 tcaagttgag aaagtcatca tcaatcaaaa ggaaaaatat ccggatgctt tagtcattga 1525201 agtggaaaca gcggatctag agcatgacat gaagatcacc ggttatgaac aggggaaaga 1525261 ggacgaactt tccagcttta ctgtcagcga aacatccttt tttattgtag acggagaaga 1525321 agtgcagatt gcgccgtata atcgccaatt tggttccaaa cctgtatggc agcggattaa 1525381 agcaattgct gcagggccga ttatgaactt tattttagct tacgtcattt tagtgatgct 1525441 tgggctgatt caaggcgtac cgtcaaatga acctatgctc gggcagctga cagacaatgg 1525501 acgggcggct gaagcagggc taaaagaagg ggattatatc caaagcatta acggagagaa 1525561 aatgaggtct tggactgaca ttgtctccgc tgtaaaagaa aacccggaga aagaaatgga 1525621 cgttgcagta aaaagagata acaaaacgct tcatatttcg gtgactccgg aagctgttaa 1525681 agatgagaac aaaaaaacaa tcggacgttt cggttcctat gcgccgactg aaaaaggcgt 1525741 actctcagcg gttgcttacg gcgcgacatc aacagttgat gtcaccaaag ccattttaac 1525801 caatctgagc aaattagtaa caggccaatt taaactcgat atgctgtcag gtcctgtcgg 1525861 catatatgac atgacagacc aagtggcgaa aacagggatc gtgaacttat ttcagtttgc 1525921 ggcgttttta agcattaacc ttgggattgt caacctgctt ccgattccgg cacttgacgg 1525981 aggaagactg ttgtttctat ttattgaagc gattcggggc aaaccgatta acagggaaaa 1526041 agaagcattt gttgtgttta tcggagtagc tttcttaatg cttcttatgc tggttgtcac 1526101 atggaacgat atccagcggc tgtttttgta aacgaaaagt aaatcaatca gaggtgcgaa 1526161 gaaatgagac aaagcttgac gcttattcct acgctccgtg aagttccagc tgatgccgaa 1526221 gcaaaaagtc atcagcttct tctgagagca ggatttatca gacagaatac gagcggggta 1526281 tacagctata tgcctcttgc gtataaggtg attcaaaaca ttcagcagat tgttcgagag 1526341 gaaatggaga aaattgatgc cgtagaaatg ctcatgcccg cattgcagca ggcagagaca 1526401 tggcaggaat caggcagatg gtatacgtat ggtcccgaac tgatgagact aaaagaccgt 1526461 catggccgtg aatttgcttt aggggcaacg catgaagagg ttatcacttc gcttgttcgc 1526521 gatgaggtta aatcttataa gcgtctccct ctgactcttt atcaaattca gtctaagttc 1526581 agagatgaaa aacgtcctcg cttcggtttg ttaagaggcc gcgaatttat tatgaaggat 1526641 gcgtactctt tccatgcatc tgcagagagc ctggatgaaa cgtatcaaaa aatgtacgag 1526701 gcctattcta atatttttgc ccgctgcggc attaatgtaa gacctgttat cgctgattca 1526761 ggcgcaatgg gaggaaagga tacgcacgaa tttatggcac tttctgcgat cggagaggat 1526821 acgattgcgt attctgatga atcacagtac gcggctaata tcgagatggc tgaagttctt 1526881 caccaggaag ttccttcaga tgaagagcct aaagctctag agaaggttca tacgcctaac 1526941 gtgaaaacaa tcgaagaact gactgcgttc ttacaggttt cggctgaagc gtgcattaag 1527001 tcagtattgt ttaaagctga tgaccgtttt gtcttagtgc ttgtaagagg ggatcatgaa 1527061 gttaacgata ttaaagtgaa aaacttgctt catgcagaag ttgtagagct tgctacacat 1527121 gaagaggtca ttcagcagct cggaacagag ccaggctttg taggccctgt cggtattcat 1527181 caggatgtgg aagtatatgc cgatcaagct gtgaaagcaa tggttaatgc tgttgccggg 1527241 gcaaatgaag gagatcatca ttataaaaat gtcaatgtga atcgtgacgc gcaaattaaa 1527301 gaatttgctg atcttcgttt tattaaagaa ggtgatcctt caccagacgg caagggaacg 1527361 atccgttttg ctgagggaat cgaagtcgga caagtcttta agctcggaac acgctattca 1527421 gaagcgatga atgcgacata tttagatgaa aacggacgcg cgcagccaat gctgatgggc 1527481 tgttacggaa tcggtgtgtc aagaacgctt tctgctattg ctgaacagca tcacgacgaa 1527541 aaaggcttaa tatggccaaa aagcgttgcg ccgtacgatc ttcatattct tgctttgaac 1527601 atgaaaaacg atgggcaaag agagcttgct gaaaagctgt atgccgattt aaaagcggaa 1527661 ggctatgaag tgctctatga tgaccgtgct gagcgtgccg gcgtaaaatt cgctgattca 1527721 gatttaatcg gccttccaat ccgcatcact gtcggaaaac gagctgacga aggaatcgtc 1527781 gaagtgaaaa ttcgtcaaac tggtgagtca actgagattt cagtagacga attatctgcg 1527841 tttatcagca agcagtaatc accataacga tttatcaaaa aacatgttaa aatagaaata 1527901 atagaaggta cctcattgcc tgaggtacct tcacttatga tgtttttagg gagggatact 1527961 gtcttaatgg aacagttatc agtaaacaga aggcagtttc aaattcttct gcagcagatt 1528021 aatatgacag atgatacctt catgacatac tttgaacatg gcgagattaa aaagctgaca 1528081 attcacaaag cttctaagtc ttggcatttt cattttcaat ttaaatcttt gctgcctttt 1528141 caaatatatg acacattaac aacgaggctg acgcaatcgt ttgcccacat agcaaaagtg 1528201 acatcttcaa ttgaagttca ggatgccgag gtcagtgaaa gtatcgttca agactactgg 1528261 tcacgctgca ttgaagaact gcagggcatt tcgccgccga ttatcagtct tttaaaccag 1528321 caaaaaccga agctgaaggg caataaactg attgtcaaaa ccaaaacaga tacagaagcg 1528381 gctgcgctaa agaacaaata cagttccatg attcaagcag aataccgtca atttggcttt 1528441 ccggatcttc agcttgatgc tgaaatattt gtatccgagc aagaagttca aaagtttcgg 1528501 gagcaaaagc ttgcggaaga ccaagagcgg gctatgcagg ccttgattga aatggagaag 1528561 aaagataaag aaagtgatga agaccaagca ccatctggtc ctcttgttat cggttatcaa 1528621 attaaagata acgaggaaat ccgaacactt gacagcatca tggacgaaga acggagaatt 1528681 acggtccaag gttatgtgtt tgatgtggag acgcgcgagc tgaagagcgg gcgcacgctg 1528741 tgtatcttca aaattacaga ctatacaaat agtattttga tcaaaatgtt tgcacgtgaa 1528801 aaagaagatg cggcgctgat gaagtctctg aaaaaaggaa tgtgggtaaa agcacgcgga 1528861 agcattcaaa atgatacatt tgtcagagac cttgtcatga tcgcaaatga cgtaaacgaa 1528921 ataaaagcaa aaacccgtga agattcagca cctgaaggag aaaaaagagt ggaattgcat 1528981 cttcattccc caatgagcca aatggatgct gttacgggta tcggaaagct tgtcgaacag 1529041 gcgaaaaaat gggggcatga ggccatcgct ttgaccgacc atgctgtcgt tcaatccttc 1529101 cctgatgcgt attctgcggc caaaaagcat ggaattaaaa tgatttacgg gatggaagcg 1529161 aatctcgtgg atgatggcgt gccaattgct tataatgccg cacatcgtct gctcgaagaa 1529221 gaaacatatg ttgtttttga cgttgagacg acaggattgt ctgctgtata cgataccatt 1529281 attgagctgg ctgcagtaaa agtaaaaggc ggagaaatta ttgataaatt tgaggcgttt 1529341 gcgaacccgc atcgtccgct ttccgccaca atcatagagc tgacagggat cacagatgat 1529401 atgctacaag acgctccgga tgtcgtagat gtaataagag atttcagaga atggattggc 1529461 gatgatattc ttgtcgctca taatgcaagc tttgatatgg gattcttaaa tgtagcctat 1529521 aaaaaacttc ttgaagtcga aaaagctaaa aacccagtca ttgatacgct tgaacttgga 1529581 cgttttctct atccggaatt taagaaccac cggttgaaca cactttgtaa aaagtttgat 1529641 atcgagctca cacagcatca ccgtgcgatc tatgatactg aggcaaccgc ttatttgctt 1529701 ctgaaaatgc tgaaagacgc agctgaaaaa ggtattcagt accatgatga gttgaatgaa 1529761 aatatgggtc agtccaatgc ttatcaaaga tcaagaccgt atcatgcaac attacttgcc 1529821 gtgaacagca cgggacttaa aaatttattt aagcttgtgt cactttctca tattcattat 1529881 ttttacagag tgccgcgtat tccgagatct cagcttgaga aatacaggga agggcttctg 1529941 atcggttctg cttgtgacag gggagaggtt tttgagggaa tgatgcaaaa atcgcctgaa 1530001 gaggtggaag atatcgcgtc attctatgat taccttgagg ttcagccgcc tgaagtgtat 1530061 cgtcacttgc tggagcttga actggtccgt gatgaaaaag cgctgaaaga aattattgcg 1530121 aatatcacga agctggggga aaagcttaat aaaccggttg ttgctacggg aaatgttcat 1530181 tacttgaatg atgaggataa aatctacaga aagattttaa tatcctcaca aggcggggca 1530241 aatccgctga ataggcatga actgccgaaa gtgcatttca gaacgacaga cgaaatgctt 1530301 gaagcttttt ctttcttagg tgaagaaaaa gcgaaggaga tcgtagtcac caatacccaa 1530361 aaggttgctt ctttagttga tgacatcaag ccgattaaag atgatttata tacgccgaaa 1530421 atcgaaggcg ctgatgaaga gatcagagaa atgagctatc agcgtgcaag aagcatttac 1530481 ggggaagagc tgcctgaaat tgtcgaagcg cggattgaaa aagagttaaa gagtattatt 1530541 ggccacggat ttgctgttat ttacttgatc tctcacaaac ttgtaaaacg ttcactagat 1530601 gacgggtatc tcgttggttc ccgtggttcc gtaggatctt cattagttgc gacacttact 1530661 gagattactg aggtaaaccc gctgccgccg cactatgttt gtcctgagtg ccagcattct 1530721 gagttcttta atgacggttc tgtcggttct ggttttgacc tgcctgacaa gacatgccct 1530781 cattgcggaa cgcctttgaa aaaagacggc catgatattc catttgaaac gttcttagga 1530841 tttaaagggg acaaagtacc tgatatcgat ttgaacttct caggggaata tcagccgcaa 1530901 gcacacaatt acacaaaagt attgttcgga gaagacaatg tatatcgtgc gggaacaata 1530961 ggcacggtgg cagaaaaaac agcctacggt tatgtaaaag gctatgccgg agacaacaat 1531021 cttcatatgc gcggtgccga aatagatcgg ctcgtacagg gatgcacagg tgtaaaacgt 1531081 acaactggac agcaccctgg cggtattatc gtagttccgg attatatgga tatttatgat 1531141 ttttcaccga tccagttccc ggcagatgcc acaggttcag agtggaaaac gactcatttt 1531201 gatttccact ccatccatga caacctgtta aaacttgata ttctcggaca cgatgacccg 1531261 actgttattc ggatgcttca agacttaagc ggaatagatc cgaaaacaat tccgacggat 1531321 gatcctgaag tgatgaagat cttccaggga accgaatcac tcggtgtgac tgaagaacag 1531381 attggctgta aaacgggcac tcttggaatt cctgaattcg gaacccgatt tgtccggcag 1531441 atgcttgaag atacaaagcc gaccactttt tctgagctcg ttcagatttc aggcttgtct 1531501 cacggaactg atgtatggct tggcaatgca caggagctca tccacaataa tatttgtgag 1531561 ctgagtgagg ttatcggctg ccgtgatgac attatggttt atttaatcta tcaaggcctt 1531621 gagccgtccc ttgcctttaa aatcatggaa ttcgtgcgta aaggaaaagg attaacgcct 1531681 gaatgggaag aagaaatgaa aaataacaat gtcccagact ggtatattga ttcctgtaaa 1531741 aagattaaat acatgttccc gaaagcccac gccgcggcat atgtcttaat ggcagtccgc 1531801 attgcttact ttaaagtgca tcatgctctt ttgtattatg cggcttattt taccgttcgt 1531861 gcagatgact ttgatattga tacaatgatc aagggctcta cagcaatcag agcggtaatg 1531921 gaggatataa acgctaaagg acttgatgct tcaccgaagg aaaagaacct tctgactgtt 1531981 ttagaattag cgcttgagat gtgtgagaga ggctattcat tccaaaaagt cgatttatat 1532041 cgctccagcg ccacagagtt tattattgac ggcaacagtc ttattccgcc gtttaactct 1532101 attccagggt tagggacgaa cgctgctttg aacattgtaa aagctcgcga agaaggcgaa 1532161 ttcctctcaa aagaagattt gcaaaagaga gggaaagtat caaaaacgat tttagagtac 1532221 ttagatcgcc atggctgtct ggagtcactg cctgatcaaa accaattgtc actgttctaa 1532281 tatggaaagc agaatttctc agaaattctg cttctatgca tacataagcg caaaaagtgc 1532341 catcgtaata ttagagtttc tgtcacttgc ttaggtatga aggtaagcgt atatccattt 1532401 gcaataaaaa tatggttatg gtatagtttt attggaaatg ctaacgatta ccgaggcaaa 1532461 gagtggggaa acccgctctt ttgtattgaa caggagaatt ttgtctcgac atgttcatcg 1532521 tttacttttt agcccctgct cttttgaagc agggttttta tgcagagtga cgagacgaat 1532581 atgagatcga cagcacaagg aggaagaaca tgagcaaaaa agtgactgac accgttcaag 1532641 aaatggctca gccaatcgta gacagccttc agctggaact cgttgacatt gaatttgtca 1532701 aagagggcca aagctggttc cttcgcgtgt ttattgattc cgatgacggt gtggatattg 1532761 aggaatgtgc caaagtaagc gaagctttaa gcgaaaagct tgatgaggca gacccaatca 1532821 gccaaaatta ctttcttgaa gtctcatctc caggagctga gcgtccgcta aagaaaaaag 1532881 ccgatttcga aaaatcacta ggaaaaaacg tatacattaa gacgtatgag cctattgacg 1532941 gcgtaaaagt gtttgaaggt gaactggctg aatttgatgg acaaacagtg acagttgaga 1533001 tcacgatcaa aacaagaaag aaacggatca atattccgta tgaaaagata gctaatgcaa 1533061 gattagctgt tacattctaa tgaatacaaa tgttttaagg ggggagaccg ttaaatgagc 1533121 agtgaattat tagatgctct cacgattctt gaaaaagaaa aaggcatcag taaagaaatt 1533181 atcatcgaag caatcgaagc tgcgttaatt tctgcttata agcggaattt taatcaagcg 1533241 caaaatgtac gggtggatct aaaccgtgaa actggctcca tccgtgtatt tgcaagaaaa 1533301 gatgtcgttg acgaagtata cgaccagaga ttagaaatct caattgaaga ggcacagggc 1533361 atccatccgg aatatatggt cggcgatgtc gtcgaaatcg aagttacacc taaggatttc 1533421 gggcgcatag ctgctcaaac agcgaagcag gtcgtcacac agcgtgtgcg cgaagctgag 1533481 cgcggtgtga tttattctga atttatcgac cgtgaagaag acatcatgac agggatcgtc 1533541 cagcgtctgg acaataaatt tatctacgtg tctttaggca aaatagaagc cttgctgccg 1533601 gttaatgagc aaatgccgaa tgaaagctac aagccccatg accgcattaa ggtatatatc 1533661 acaaaagtag aaaaaacaac gaagggtccg cagatttatg tgtcaagaac acatccaggc 1533721 ctgttaaagc gtttgtttga aattgaagtg cctgaaattt atgatggaac tgtcgagcta 1533781 aaatctgttg ccagagaagc cggcgaccgt tcgaaaattt ctgttcgcac agatgatcct 1533841 gacgttgatc ctgtcggttc atgcgtaggg cctaaaggcc agcgtgtgca agcaatcgtc 1533901 aatgaattaa aaggtgaaaa aattgacatt gtcaactggt ccagtgatcc tgtagaattt 1533961 gtcgcgaatg cgctcagccc ttccaaagtg cttgatgtca ttgttaatga agaagaaaaa 1534021 gcgacaactg ttattgttcc tgattaccag ctgtctctgg caattggaaa aagaggacaa 1534081 aacgcacgct tagctgctaa actgacaggc tggaagattg atattaagag cgaaacggac 1534141 gcaagagaac ttggaatcta tccgagagaa cttgaagaag atgatgagcc gctctttacg 1534201 gagcctgaaa ctgctgaatc ggatgaataa gaggtgactt taggtgaata aacacaaaaa 1534261 gatcccatta cgcaaatgtg tagtgactgg tgaaatgaag cctaaaaagg aactgatccg 1534321 agttgtacgg tcgaaagaag gcgaaatctc agtagacccg accggaaaaa agaatgggcg 1534381 gggtgcttat ttaacgctgg ataaagagtg catcttagca gcaaaaaaga aaaacacttt 1534441 gcaaaatcaa tttcaatcac aaatcgatga ccagattttc gatgaattgc tggaactggc 1534501 ggaaaaggtg aaaaaataaa atgtctggaa tggaatggtt tcccttgctg ggtctggcca 1534561 atcgagctcg taaggtcgtg tcaggcgaag acttggtaat aaaagaaatc aggaatgcgc 1534621 gtgcaaagct tgtcctgctt acagaggatg catcatctaa cacagcaaaa aaagtaactg 1534681 acaagtgcaa ttattataaa gtcccttata aaaaagtcga gagtcgcgcg gttcttggac 1534741 gctctatcgg taaagaagcc cgtgtcgttg tcgccgtcac tgaccaaggt tttgcgaata 1534801 agctgatcag cttgctcgat taatattttt gggggtgaac gaatggctaa aatgagagta 1534861 tacgaatatg caaaagcgtt aaatgtttca agtaaggaaa ttttgaccgc actgaagaac 1534921 atggatttag aagtgaataa tcacatggcc atgcttgaag aaaaggccat taaaaagcta 1534981 gatgccaaat ataaaaaagg cggcgcagct gctaaatctc aaaagccagc agaaacgaac 1535041 aaaaacaaac agccacaagg ggttaatcag caatcagctg gaaatcaacc aaataaaatt 1535101 cgagacggaa agaagaatga cgtgcagaat aatcaattta acaaaaacaa gaagaataac 1535161 aacaacaaaa aaaataaacg caacaacaac aataataaaa accaacatca gcaaaagcct 1535221 gtaaagccga aaaaagagct tcctgagaaa attacattct ctggcacttt aacagttggc 1535281 gcacttgctg aagagcttgg caaagagcct tcagaactca ttaaaaagct gatgcttctt 1535341 ggcgtaatgg caaccattaa ccaagagctt gataaagaca caatcgaact cattgcatca 1535401 gaatatggtg ttgaaacaga agaggtcatt gtgcttgaag aaacagagct ggaaaaatac 1535461 gaagagcctg ataatgaaga ggatcttgaa attcgtcctc ctgtcgtgac aatcatgggc 1535521 cacgttgacc atgggaaaac aacgcttctt gacagcatcc gtaaaacaaa ggttgttgaa 1535581 ggggaagcag gcggaatcac tcagcatatc ggcgcttatc aaattgaaga gaacggcaag 1535641 aaaatcacgt tcttggatac accgggccac gccgcattta caacaatgcg cgcacgcggt 1535701 gcagaagtaa ctgatattac gattcttgtc gtagctgccg atgacggtgt catgccgcaa 1535761 acagttgaag cgattaacca tgcaaaagca gcagaggttc caatcatcgt tgctgtgaat 1535821 aaaatagata aagaatccgc aaaccctgac cgtgtaatgc aagaactgac ggaatacgga 1535881 cttgtccctg aagcttgggg cggagaaacc atttttgtgc cgctttccgc tttaactgga 1535941 aaaggcattg atgagctcgt tgaaatgatt ttgcttgtca gtgaggtaga ggaactgaaa 1536001 gcgaatccga atcgtcaggc aaaaggaacg gttattgaag ctgaactcga taaaggcaga 1536061 gggtcagtcg cgacgttgct cgtacagact ggaacactgc atgtcggtga tccgatcgta 1536121 gtcggcaata catttggccg tgtccgtgca atggtcaacg acattggccg ccgtgtgaaa 1536181 actgccggcc cgtcaactcc ggttgaaatt accggtttga atgatgtccc tcaagcggga 1536241 gaccaattcc ttgtctttaa ggatgaaaaa acagctcgtt ctgtcggtga agcccgtgct 1536301 tcgaaacagc ttgaagagca gcgcagcgat aaagcgaagc tcagtcttga tgatttattt 1536361 gagcaaatta agcaaggtga tgtaaaagac atcaacctca tcgtaaaagc tgacgttcaa 1536421 ggatctgctg aagctttaac ggctgcactt caaaaaattg aagtagaagg cgttaaagtg 1536481 aaaatcatcc atacaggcgt tggtgcgatt actgaatcag acattatctt ggcatctgct 1536541 tccaatgcaa ttgttatcgg gtttaatgtg agaccggacg gaaatgctaa gagtacggct 1536601 gaagctgaaa atgtagatat tcgacttcac cgtatcattt acaaagtaat cgacgagatt 1536661 gaagctgcca tgaaaggtat gcttgatcct gaatatgaag aaaaagtaat tggtcaagta 1536721 gaagtacgcc aaacattcaa agtatctaaa atcggtacaa ttgccggcgg atatgttact 1536781 gaaggaacca ttacgcgcga cagcggcctc cgtttaattc gtgacggcgt cgtcatcttt 1536841 gaaggcgaag tagatgttct gaaacgcttt aaagacgatg tgaaagaagt ttcacaaggc 1536901 tatgaatgtg gtattacaat taagaaatac aatgacattc gtgaaggtga catccttgaa 1536961 gcgtttgtca tgcaagaaat tgaaagaacg tgatcggatt tgcggagtgt gaatgcatca 1537021 tttatgatgc aggatcgcta aaagaaaagc gtgccgttct gaagcggatt ttaaccaggg 1537081 ttcaaaacaa gttcaatgtt tcgatttcgg agattggcta tcaggacacc tggcaaagaa 1537141 ccagcttcgg aatcgccgct gtttcttcct ctcgcgttca aacagaaaaa gaactgcagc 1537201 gcgtcctagc gtttatcgat tcttttcctg aaattgaacg gacgatcact aggacagagt 1537261 ggttttaact tagaggtgat tgaattgagt atgagagcaa accgtgtcgg cgagcaaatg 1537321 aaaaaagaac tcggtgatat tatcagccgc aagctgaaag acccgagaat tggttttctg 1537381 acagtaacgg atgtacgtgt atcaggtgat ttgcaaattg caaaggtgta tatctcggtt 1537441 ctcggtgacg agaaaaaacg ggaagaagcg ctgaaagggc tggcaaaagc gaaaggattt 1537501 atccgatccg aaatcggcag ccgcatcaga cttcgaaaaa cgcctgaaat tgaatttgag 1537561 ttcgatgaat caatcgatta cgggaatcgg atcgaaacac tgattcacga attacattca 1537621 gagaaaccat ctgaataaaa aaagagagga taggcgtata tcgtctgtcc tctttcttcg 1537681 tttataagaa aaaaactcaa aagaaggagt gaaaggcaaa tggttaacgg agttctcctt 1537741 ttacataaac ctgttggcat gacatcgcac gactgtgtca tgaagatccg aaagctgtta 1537801 aaaacaaaaa aagtaggaca tacaggaacg ctcgatccgg aagtatcagg cgtgcttccg 1537861 atttgtgtag gaagagcgac aaaaatagtc gaatacttaa ctgaaaaatc taaaacgtat 1537921 gatgcagaaa taacattggg cttttcaacc acaacagagg atcaaaccgg agaaacggtg 1537981 gaaacaaagc ctgtcaatca cgacattgat aaagcggatg tagaaaaggt tttaaacagt 1538041 ttaaagggga aacaagaaca aattccgccc atgtattccg ctgtaaaagt aaacggcaaa 1538101 aaattatacg aatacgcaag agcagggatt gaagtagaac gtccgaaacg tatgataacc 1538161 attgaagaca ttgccctgac aacagagatt aaacatcatg gagaaaccgc aagcttccgg 1538221 tttacagtga cttgctccaa agggacctat gtaaggacgc tggcggtcat gatcggagaa 1538281 aagctcggat atccggccca tatgtctcat ttaatccgta cggcatccgg agatttttct 1538341 ctcgacgaat gctttacttt tgatgaactc gaagcacagg cccaatccgg aaccgtggaa 1538401 gagcatacag ttcctattga acgtgcgctc aatcatttgc cgaaatggat cataagtgat 1538461 acattagcta agaaagtaga aaatggggct ttgcttgaga cgcccgagca gttttctgaa 1538521 atgacaagtg gagaccgtat tgccgtcttt actgaatccg gaacctgctt ggcgatctat 1538581 ttccctcatc ctgcaaaaaa agggctgtta aagccggcaa aagtattgat gcaaaaaagc 1538641 gaacaataga aaaaaggtga ccgttctgtg aagacgatac atattacaca tcctcatcat 1538701 ttaataaaag aggagcaggc aaaatcagtg atggcgttag gttattttga cggcgttcat 1538761 ctcgggcatc aaaaggtaat cggcacagcg aagcaaatag ccgaagaaaa aggtctgaca 1538821 ttagctgtga tgacctttca tccccatcct tctcacgtgt tgggcagaga taaggaacca 1538881 aaggatctga ttacgcctct tgaagacaaa ataaaccaaa ttgaacaatt aggcacagaa 1538941 gttctgtatg tcgttaaatt taatgaagtg tttgcttctc tttctcctaa gcagtttata 1539001 gaccagtata ttatcggcct taatgtgcag cacgcagtgg caggctttga ctttacgtac 1539061 ggcaaatacg gcaagggaac aatgaagacc atgccggatg atttagacgg aaaagctggg 1539121 tgcacaatgg tagaaaaatt aacggagcag gataaaaaaa tcagttcttc gtatatccgt 1539181 accgcgcttc aaaacggaga tgttgaattg gcgaatgtct tgcttggaca accttatttt 1539241 attaaaggaa ttgtcattca tggtgataaa agagggcgga ccatcgggtt tccgacagcg 1539301 aatgtcggtt taaataacag ctatatcgtt ccgcccacag gtgtatatgc cgtaaaagcg 1539361 gaagtgaacg gcgaagttta caatggcgtt tgcaatattg gctataagcc aacgttttat 1539421 gaaaagcgcc ctgaacagcc ttccatcgag gtcaatctgt ttgatttcaa tcaagaggta 1539481 tatggagccg ctataaaaat cgaatggtac aaacggattc ggagcgagcg gaaattcaat 1539541 ggcatcaaag aattaactga gcaaattgag aaagataagc aggaagccat ccgttatttc 1539601 agcaatttgc ggaaataact tgcaacgcac gcaaatttta ttctaaaata tttgcatata 1539661 ggcacgattt ttagtatgat agttttcgta gtcttaaaac cattgcttgg caatccgaag 1539721 tcaccgacgg ttgctaggta actggggcta aatatgattt ggaggtgaaa caggatggca 1539781 attactcaag agcgtaaaaa ccaactcatc aatgagttca aaacacacga atctgatact 1539841 ggatctccag aagttcagat cgctatccta actgactcaa ttaacaactt gaacgagcat 1539901 ttacgtactc acaagaaaga ccaccactca cgtcgcggtc ttcttaaaat ggtaggtaag 1539961 cgtcgtaatc ttcttacgta tctgcgtaat aaagacgtaa ctcgttaccg tgagttaatt 1540021 aacaaactag gcttacgtcg ataatcgtaa aaagcgggag gattcccgct tttttatcgt 1540081 attaaagcga aatttcttat aacaaatcat tgaaatcctt ttacatacta ctttgacatt 1540141 gatatgttca attcatttcg ttcataatag gagtaattga ttatttcaca caacgaagag 1540201 aggagttcgt aattgtatgg gacaagaaaa acatgtcttt accatagatt gggccggaag 1540261 aacgcttacc gttgaaaccg gccagcttgc caaacaggca aatggtgctg tgatgatccg 1540321 ctacggtgat acagcagtac ttagtacagc aaccgcttca aaagaaccta aaccgcttga 1540381 tttcttccct cttactgtaa actatgaaga aagattatat gcggtaggga aaattccggg 1540441 cggatttatt aaaagagaag gacgtccaag tgaaaaagcg gttcttgcca gccgtttaat 1540501 tgaccgtccg atccgtcctt tgtttgccga tggattccgt aatgaagttc aagtcatcag 1540561 cattgtcatg agtgttgacc aaaactgctc ttcagaaatg gctgccatgt tcggttcatc 1540621 tcttgcactt tctgtatcgg atattccgtt tgaaggaccg attgcagggg ttactgtcgg 1540681 acgcattgat gatcaattta tcattaaccc gacagtcgat cagcttgaaa aaagcgatat 1540741 caatcttgtc gttgccggca cgaaagatgc gattaacatg gtagaagcgg gagcggacga 1540801 agttcctgag gaaatcatgc ttgaggccat tatgttcggc catgaagaga ttaaacgcct 1540861 gattgcattc caagaagaaa ttgttgcagc agtcggcaaa gagaaatctg aaattaagct 1540921 ctttgaaatt gatgaagagc ttaatgaaaa agtaaaagct ttggcagaag aggatctgct 1540981 gaaagccatc caagttcatg aaaagcatgc ccgtgaagat gccattaacg aagtgaagaa 1541041 cgcagttgtg gcaaaattcg aggatgaaga acatgatgaa gacacaatca agcaagtgaa 1541101 gcagatttta tccaagcttg tgaaaaatga agttcgccgc ctgattactg aagagaaagt 1541161 aagaccggac ggccgcggtg tcgatcaaat ccgtccgctc tcttcagagg ttggcctctt 1541221 gccaagaacg cacggttcag gtctatttac aaggggacaa actcaggccc tcagcgtatg 1541281 tacgctaggt gctctgggag atgtgcaaat ccttgacggc ttaggtgtcg aagagtcgaa 1541341 acggtttatg catcattaca acttcccgca attcagcgtt ggggaaacag gaccgatgcg 1541401 cggaccggga cgtcgtgaaa tcggacacgg agcactgggt gagcgtgcgc ttgagccagt 1541461 tattccgtct gaaaaagact tcccttatac tgtccgtctt gtttcagaag tgcttgaatc 1541521 aaacggttct acatctcaag caagcatttg cgcaagcaca cttgcaatga tggatgccgg 1541581 tgtaccgatt aaagcgccag ttgctggtat tgcgatgggt cttgtcaaat caggcgaaca 1541641 ttacactgtc ttgactgaca tccaaggcat ggaagacgcg ctcggagata tggactttaa 1541701 agtagcggga actgaaaaag gcgtaacggc cctgcaaatg gacattaaaa ttgaaggcct 1541761 ttccagagag attcttgaag aagcgcttca gcaggcgaaa aagggcagaa tggaaatcct 1541821 caacagcatg cttgcaacat taagcgaatc aagaaaagag ctttctcgat atgcgcctaa 1541881 gatcttaaca atgaccatta atcctgataa aatccgcgat gtcatcggac caagcgggaa 1541941 acaaatcaat aagatcatcg aagaaaccgg tgttaaaatt gatattgagc aggacggcac 1542001 aatctttatt tcctctacag atgaaagcgg caaccaaaaa gcgaaaaaaa tcatcgaaga 1542061 ccttgtgaga gaggttgaag tcggccaact ttacctaggt aaagtgaaac ggattgaaaa 1542121 attcggggct ttcgttgaaa ttttcagcgg aaaagacggt ttggtgcaca tttcagagct 1542181 tgcgcttgaa cgcgtaggga aagttgaaga tgttgtgaaa atcggagacg agattcttgt 1542241 caaagtcact gaaattgata aacaaggacg agtgaattta tcccgcaaag cggtgctccg 1542301 tgaagagaaa gaaaaagaag aacaacaatc ttaaatgaaa acataaaagg agcctgggag 1542361 acccggcttc tttattttga agcttttcaa aagcaggcgg gttctacctt gtccttctcc 1542421 ttcataatgt gaggtgaggg ggggacagaa catgtacaaa aaatttgtac cgtttgccgt 1542481 ttttttattt cttttttttg tctcatttga gatgatggaa aatccgcatg cacttgatta 1542541 tataggggca atgaaaaaag atacggtgac tgtcacggcg tcaaaagacc cgttatatga 1542601 agaattgctt caaaaagcgc cggagtacga agttaagccc cagaatgcaa gaattgataa 1542661 agtgtggaaa agcattccag gctacaatgg attaaaggtc aatattgaac aatcatataa 1542721 aaaaatgaaa cagcatggta agtttcggga aaaagatttg gtgtacagtc aagtaaaacc 1542781 aagtgttcat cttgagtcac ttcagcctga gcctatttat aaaggaaatc ctgacaaacc 1542841 gatggtggct tttttaatca atgtggcatg gggaaatgag tatttggaaa aaatgcttcc 1542901 tattctgcaa aagcaccagg ttaaagctac gttcttttta gaaggcaatt gggtgagaaa 1542961 caatgtacag ctcgctaaga agattgcaaa agacggacat gaaatcggaa atcattcata 1543021 caatcatccg gatatgagca aactgactac aggaagaatt tccgagcagc tcgacaagac 1543081 taatgaacaa atagaacaaa cgatcggcgt taagccaaag tggttcgctc cgccaagcgg 1543141 aagtttcaga aaagcggtta tcgacattgc agcagagaaa cagatgggaa cagtcatgtg 1543201 gacagttgat acaatcgatt ggcaaaagcc ggctccgtct gtacttcaga cgagagtgtt 1543261 aagcaagata cataatggtg ccatgatttt aatgcatccg actgacccta cggcggaaag 1543321 tcttgaagcg ctgattacac agataaaaga caaaggatat gcgcttggaa cagtcactga 1543381 actaatggat gaaacaagac tattgaagta acagatgaag gcagcttgtc tttgaatagg 1543441 aggaacaaat ttgattaaac gatatacgtg tcaaaatggt gtaagaattg tgctggaaaa 1543501 taacccgaca gtccgttctg ttgcgatcgg cgtatggatc ggcacaggtt cgagacatga 1543561 aacgccggag ataaacggaa tttctcactt tttagagcac atgttcttta aagggacgag 1543621 cacaaaatct gcacgcgaga tagcagaatc ttttgatcgt attggcggcc aggtcaatgc 1543681 gtttacttca aaggaatata cctgctacta tgcaaaggtg cttgacgagc atgcgaatta 1543741 cgcgctggac gtattagcag atatgttctt tcattcaacg tttgatgaaa acgagctgaa 1543801 aaaagagaaa aatgtagtat atgaagaaat taaaatgtat gaagatgcgc cggacgacat 1543861 tgtacatgat ttattgagca aagccactta cggcaatcat tctttaggct acccaatttt 1543921 aggaacggaa gaaacgcttg cttcctttaa cggtgactct ctcagacaat acatgcatga 1543981 ttattatacg ccggaccgag tggtgatttc ggtagcgggc aatatatctg acagttttat 1544041 caaagatgta gaaaaatggt tcgggtcata cgaggcgaaa ggcaaagcga caggccttga 1544101 gaagcctgag ttccacacgg aaaaactgac gagaaaaaaa gaaacagagc aggctcattt 1544161 gtgccttgga tttaaaggct tagaggttgg ccatgaacgt atttatgatt taatcgtcct 1544221 caacaatgtg ctcggaggca gcatgagcag ccggctgttc caagatgtgc gtgaagataa 1544281 aggacttgct tattctgttt acagctatca cagctcatat gaggacagcg gaatgctaac 1544341 gatttacggc ggaacgggtg caaatcagct tcagcagctg tcggaaacaa ttcaagaaac 1544401 cctggccaca ttaaaacgtg acggcattac ctcgaaagaa ctggaaaaca gcaaagagca 1544461 aatgaaggga agcttaatgc tgagcttaga aagcacaaac agcaaaatga gccgaaacgg 1544521 aaaaaatgaa ctgctgctcg gcaaacataa aacattagat gaaattatca atgaattaaa 1544581 cgccgtgaac ttagagcgtg ttaatggcct tgccagacaa ttgtttaccg aagactatgc 1544641 attagcactt atcagccctt ccggcaatat gccgtcttaa aaaggaaagc ctgccccata 1544701 atggagcagg cattttttaa tccctttcat catacatagt acaagggggt gacagacatg 1544761 cggctcagtg aattatcggg aaaggaaatt gtagacatca aaagagctga acggctcgga 1544821 gtgctcggcc agaccgattt ggaaatcaat gaacaggatg gacagattac agcactcctc 1544881 attcccacag ttaagtggtt tggtttgaga aagcaaggtc atgacattcg tgtcccatgg 1544941 caccatattc aaaagatcgg ttcagatatg attatattag atgtacctga ggaaatgcct 1545001 cctcgacaag agtaaatagc ccaattgact gtgaagcggg ctctaaagaa aacatctgaa 1545061 acatcggctg ccggagccga tgttttttta tatggaaaaa gcgcatcttt tatattcacc 1545121 ggtatttcct tttgatcata agatgaaggg gagcttaaca actagagatc cagtatatac 1545181 aaagaaggtg aacgtttaga atgttaaccg gattgaaaat tgcagttatc ggcggtgacg 1545241 caagacagct cgaaattata agaaagctca ctgaacagca ggctgacatc tatcttgtcg 1545301 gttttgacca attggatcac ggttttaccg gggcagtaaa atgcaatatt gatgaaattc 1545361 cttttcagca aatagacagc atcattcttc cagtatccgc gacaacagga gaaggtgtcg 1545421 tatcgactgt attttcgaat gaagaagttg tgttaaaaca ggaccatctt gacagaacgc 1545481 ctgcacattg tgtcattttc tcaggaattt ctaacgccta tttagaaaac attgcagctc 1545541 aggcaaaaag aaaacttgtt aagctgtttg agcgggatga cattgcgata tacaactcta 1545601 ttccgacagt agaaggaacg atcatgctgg ctattcagca cacggattat acgatacacg 1545661 gatcacaggt ggccgttctc ggtctggggc gcaccgggat gacgattgcc cgtacatttg 1545721 ccgcgctcgg ggcgaatgta aaagtggggg caagaagttc agcgcatctg gcacgtatca 1545781 ctgaaatggg gctcgttcct tttcataccg atgagctgaa agagcatgta aaagatatag 1545841 atatttgcat taataccata ccgagtatga ttttaaatca aacggtactt tctagcatga 1545901 caccaaaaac cttaatattg gatctggcct cacgtcccgg gggaacggat tttaaatatg 1545961 ccgagaaaca agggattaaa gcacttcttg ctcccgggct tccagggatt gtcgctccta 1546021 aaacagctgg gcaaatcctt gcaaacgtct tgagcaagct tttggctgaa atacaagctg 1546081 aggaggggaa ataaggatgt cgtcattaaa aggaaaaaga atcgggtttg ggctgaccgg 1546141 gtcgcattgc acatatgaag cggttttccc gcaaattgag gagttggtca acgaaggagc 1546201 tgaagtccgt ccggttgtca catttaatgt aaaatctaca aatacccgat ttggagaggg 1546261 cgcagaatgg gttaaaaaaa ttgaagacct gactggatat gaggccattg attcgattgt 1546321 aaaggcagaa cctcttgggc cgaagctgcc ccttgactgc atggtcattg cgcctttaac 1546381 aggcaattca atgagcaagc tggcaaatgc catgacggac agcccggtgc tgatggcggc 1546441 aaaagcgaca atccggaaca atcggcctgt cgttctgggt atctcgacaa atgatgctct 1546501 tggtttaaac ggaacaaatt taatgaggct catgtcaaca aaaaatatct tttttattcc 1546561 attcgggcaa gatgatccat ttaaaaaacc gaattcaatg gtagccaaaa tggatctgct 1546621 tccgcaaacg attgaaaagg cactcatgca ccagcagctt cagccgattc tagttgagaa 1546681 ttatcaggga aatgactaaa tttacagaaa atctttccca aactaaaaaa ttcggtcatc 1546741 acccgcatat tctatggtaa aataaaacgt aaaatcatag tcaaatcaat tcaatgaagc 1546801 tgattggcgg aaggagtttt acagatggga agaggtttac acgtagctgt tgtcggagcg 1546861 acaggggctg tgggacaaca aatgcttaaa acacttgaag acagaaactt tgaaatggac 1546921 acacttacat tgctatcttc aaaacgctct gcggggacaa aagtcacgtt taaaggccaa 1546981 gagctgactg ttcaggaagc ttctcctgag agctttgaag gggtaaatat tgctttgttc 1547041 agcgccggcg gaagcgtatc acaagcattg gcaccagaag ctgtaaaacg cggcgctatt 1547101 gttatagata atacgagtgc gttccgcatg gatgaaaata caccgcttgt tgtgccagaa 1547161 gtgaatgagg cagacttgca tgaacacaac ggcattattg ccaatccaaa ctgctctaca 1547221 atccaaatgg ttgcggcact tgaaccgatc cgcaaagcat atggcttaaa caaggtcatc 1547281 gtatcaactt accaggcagt atcaggagcg ggtaatgaag ctgtaaaaga gctttacagc 1547341 caaacacagg cgattttaaa taaagaagaa atagagcctg agatcatgcc tgtaaaaggt 1547401 gacaaaaaac actatcaaat cgccttcaac gcgattccgc aaatcgataa attccaagat 1547461 aacggctata cgtttgagga aatgaaaatg ataaatgaaa cgaaaaaaat catgcacatg 1547521 cctgaccttc aagtagcggc tacatgtgtg agactgccaa tccaaactgg gcactcagag 1547581 tccgtctaca tcgaaataga ccgtgatgac gctacagttg aagatattaa aaatctattg 1547641 aaagaagctc cgggcgtgac acttcaggat gatccaagcc agcagcttta tccgatgcct 1547701 gctgatgctg tcggcaaaaa cgatgtgttt gtaggccgca tccgcaaaga cttggacaga 1547761 gcaaacggtt ttcatttatg ggttgtttct gataacctat taaaaggcgc ggcatggaac 1547821 tctgttcaaa ttgcagaaag cctgaaaaaa ctaaacctcg tataaaagag agaattttct 1547881 aaagacgaat agaagagagt aaggcgctat cagcctgctc tcttctgtta cgtccgaata 1547941 atttggagtg aaaacagtga agataattgt tcaaaagttc ggcggaacat cagtaaaaga 1548001 tgataaaggc cgcaaactgg ctttagggca tattaaagaa gcaatcagtg aaggatataa 1548061 ggttgtcgtt gtcgtttcag cgatgggccg aaaaggggac ccgtatgcaa cagattcttt 1548121 gctcgggctg ctttacggcg atcagtcagc gatttctcct agggagcagg atttgctttt 1548181 atcttgcgga gagactattt cctctgtcgt ctttacaagc atgctgcttg ataacggtgt 1548241 gaaagcagct gcgctgacag gggctcaggc tggcttttta acgaatgatc agcatactaa 1548301 tgcgaaaatc attgaaatga aaccggagcg tttattcagt gtgctcgcca atcatgatgc 1548361 ggtagtcgtc gcaggcttcc agggcgcaac tgaaaagggt gatacaacaa caatcggcag 1548421 agggggcagc gatacgtctg cagccgcact cggagcagct gttgatgcgg aatacatcga 1548481 tattttcacc gatgtagaag gcgtgatgac tgctgaccca agagtggtag aaaatgcaaa 1548541 accgcttcct gttgtgacgt atacggaaat ctgcaacctg gcgtatcagg gggccaaggt 1548601 catttctccg cgtgctgtgg aaatcgcaat gcaggccaag gttccgatcc gcgtccgttc 1548661 gacttattcg aatgataaag gcacattggt gacatcacat cactcttcca aggtcggcag 1548721 tgatgttttt gaaaggctga ttacgggaat cgcccatgtc aaagatgtca cgcagttcaa 1548781 agtgcctgcg aaaatcggcc agtataacgt tcagactgaa gtgttcaagg ctatggcaaa 1548841 cgctggaatc agtgtcgatt tctttaacat tacacctagt gaaatcgtct atacggtagc 1548901 cggaaataaa acagaaacag ctcagcgtat tttaatggat atgggctatg atccaatggt 1548961 gacgagaaac tgcgcgaagg tatcggcggt cggcgcgggc attatgggtg ttcccggtgt 1549021 tacgtccaaa attgtatcgg ctctttcaga aaaagaaatt ccgatccttc agtcggctga 1549081 cagccatacg acgatatggg tgctcgtcca tgaagcggat atggttcctg ctgtaaacgc 1549141 tttgcatgaa gtgtttgaac tttcgaagta aatgtgattg aatcatgatg aggtgaataa 1549201 aatgaatttc ggaaatgtgt ctacagcgat gattacaccc tttgacaata aagggaacgt 1549261 agactttcaa aaactgtcta cactgattga ttacttgttg aaaaacggaa cggattcttt 1549321 agtagtagcg ggaacaactg gagaatctcc gaccctttca actgaagaaa aaattgcgct 1549381 ttttgaatat acggtaaaag aagtaaacgg acgggtgccc gttatcgctg gtactgggag 1549441 caacaacacg aaagattcca ttaagctgac aaaaaaagct gaggaagcgg gcgtggacgc 1549501 tgttatgctt gttaccccgt attacaataa accttctcaa gaaggaatgt accagcattt 1549561 taaagcaatt gcggcagaga catctcttcc ggttatgctc tataatgttc ctggccgtac 1549621 ggttgcttct cttgctcctg aaacgacgat ccgtttggcg gcagacattc cgaatgtggt 1549681 tgcgattaaa gaagcgagcg gagacctcga agcgattaca aaaattattg ctgaaacacc 1549741 tgaagacttc tatgtctatt caggggatga tgctctaacg cttccaattc tttcagttgg 1549801 aggtagagga gttgtgtcag tggcgagcca tattgcaggc actgatatgc agcaaatgat 1549861 caaaaattat acgaatgggc aaacagctaa tgcggcactg attcatcaga aactgctgcc 1549921 gattatgaag gaactgttta aagcgcctaa tcctgctcca gtcaaaacag cgcttcagct 1549981 gagaggtctt gatgtcggtt ctgtgcgtct gcctctagtc ccattaactg aggatgaacg 1550041 tctgagctta agcagcacga tcagcgaact gtaagaaaat ttcatacagt gaaacaaacg 1550101 cggtcattct cacattcagc tgagtttgac cgtttctttt acatattggt tttccctaaa 1550161 ccttctgctt tatcttgttt tctaaattta ctttcagtta taataggaac aagtgatgat 1550221 ggacgggtat gagactagga ggatatagat tttgaaaaag aaaaatacag aaaacgttag 1550281 aattatcgcc cttggcggtg tcggagagat tgggaagaac ctttatgtca ttgaaattga 1550341 ctcagacata tttgtcgttg atgccggcct tatgcatcca gaaaacgaaa tgctcggtat 1550401 tgatgtagtg attcctgaca tatcatattt gattgaacgg gctgaccgcg tcaaggcaat 1550461 ctttttaacg cacgggcacg atgaaaatat cggcggcgtt ttttacttat taaacaagct 1550521 gtccgttcca gtgtacggaa caaaactgac gcttgcactg ttaagagaga aattaaaaca 1550581 atacggacat aaccgaaaaa ctgatttaag agaaattcac tccaaatctg tcattacatt 1550641 tgaatcaaca aaggtatcgt tctttagaac gattcacagc attcctgatt ctgtaggtgt 1550701 gagctttaaa acatcacttg gatctattgt atgcacggga gacttcaaat ttgaccaaac 1550761 acctgcactt aatcagacgt gcgacattgg cgagatcgcc aagatcggca atagcggcgt 1550821 gctcgctctg ctttctgaca gtgcaaatgc ggaacggccg ggttacaccc cttcggaagc 1550881 ggctgtcagc ggagaaattt cggatgcgct gtataattca cagaaccggg tgattattgc 1550941 tgttttcgca tccaatatta accggattca gcaagtcatt catgcagcgg ctcaaaatgg 1551001 cagaaagatt gccgtagccg gaaaaaatct tcaatctgtc ctgcagctgg cgagaaagtt 1551061 aggatatatt gaagcagatg atgaattgtt tatttctgta caggatgtca aaaaatatcc 1551121 gaagcgcgaa gtggccatta ttacagccgg aagccaaggt gaaccattag ctgctttgac 1551181 aagaatggca aacaaagctc acaaacagct gaacattgaa gaaggggata cggtggtcat 1551241 tgcgtcaact ccgattcccg ggcaggaact catttactct aaaacagtag atcttcttgc 1551301 gagagccggt gcacaagtca tctttgccca aaagcgtgtt catgtatcag gccacggctc 1551361 acaagaagag ttaaagctga tgatcaacct gcttaaacca aaatatttga ttcctgtaaa 1551421 cggcgaatac agaatgcaaa aagctcattc aaaaatcgct gaagaaaccg gcatgaagcg 1551481 cagtgacatc ttcttaattg aaaaaggcga cgtcgttgaa ttccgcggcc aaaacgtaaa 1551541 aattggggat aaagttcctt acggcaatat tttaattgat ggtttaggtg tcggtgatat 1551601 cggcaatatc gtattgagag accgccgctt gctttcacag gacggaattt taatcgttgt 1551661 cattacactt gataaacaaa agaaacatct tgtatcagga ccagaaatta tcactcgcgg 1551721 ctttgtttat gtaagagagt ctgaaggtct tatcgtacag gctactgagc ttgtacggtc 1551781 catcgtgaca gaagcgactg aaacatcaaa tgtcgaatgg tcaacgctga agcaggcaat 1551841 gcgggatgct ttgaaccaat tcctttatga aaaaacgaaa cgtaaaccga tgatcatccc 1551901 aattattatg gaagtataat gactgactaa agaccggagc tgctccggtc tttatttttt 1551961 gtccttcaag ccgggattga atgaagtatc tttgttcata atacaaagag aaactcggaa 1552021 aggatgaaag cgagatggat catcgtatgg aaaacacaga agaagagcgt cctgaaaaaa 1552081 atgatgcgaa ggacagcatt atgaataaaa tacagcagct tggtgaaacg acgcttccgc 1552141 agctgcccca agatacaaat attcattgtc tgaccattat cggacaaatt gaaggccatg 1552201 ttcagcttcc tccgcaaaac aaaacaacaa aatatgaaca tgtcatcccg cagattgtgg 1552261 caattgaaca aaatcccaaa attgaaggct tgctgatcat attaaatact gtcggaggag 1552321 atgttgaagc tggtcttgcc atagcggaaa tgcttgcatc tttatcgaaa ccgaccgttt 1552381 ctatcgtgct tggcgggggg cattcaatcg gcgttccgat tgctgtatcc tgtgattaca 1552441 gctatatcgc cgaaacagca acgatgacga ttcatccagt taggctcacc gggctggtca 1552501 tcggggtgcc gcaaacgttt gaatacctgg ataagatgca agaaagagtt gttaaatttg 1552561 tgacaagcca ttccaatata accgaagaga agtttaaaga gctaatgttt tcaaaaggaa 1552621 acttaacacg cgatatcgga acaaatgtag tcggtaagga tgcagttaaa tacggattga 1552681 tcgatcacgc aggcggtgtc ggacaggcaa tcaataaact gaatgagctc atcgatgaag 1552741 caaggaaaga agaaggacgg atgattcaat gattctttat accgtgatgc ctcaggaaat 1552801 tgtgtttgca gaacagaacc aagagacaag cgcacatgag caaattgaat ataaaggtgt 1552861 accgcttcta gtcgaaatga aagggaatga agcggaagtc attcaaatca tgagcaccaa 1552921 tccaatgcat tttctgcatc cggacatttc accgggacaa aagctgaaat taaacgtata 1552981 agaatccaac ccttttttaa gggcaaaata tgctataata ggggaatcct acagaaaaaa 1553041 cgcagcctgt aaacggctgc tttcttcatt atgtatgaac ttacattttt taacgcagta 1553101 aggtgatgag tgtggcaaag aaaaaacgaa aatcaagaaa aaaacaggcg aaacagctca 1553161 atataaaata cgagctcaac ggattgctgt gtatagccat ttcaattatc gcaatcttgc 1553221 agctgggggt agtcgggcaa acgtttatct atttgttccg cttttttgct ggagagtggt 1553281 ttattttatg cttgttaggt ttattggtgt taggagtctc actgttttgg aagaaaaaaa 1553341 ccccaagcct tttaacgaga cgaaaggccg ggttgtactg tattatcgca agcatattgc 1553401 tgctttctca cgtgcagcta tttaaaaatt tgacgcacaa agggtctatt gagtctgcaa 1553461 gcgtggtgcg caatacgtgg gaattgtttt taatggacat gaatggcagc tctgcttcac 1553521 ctgatttagg cggagggatg atcggtgcgc tgctgtttgc ggcttcacac tttttgtttg 1553581 cgtcgactgg ttctcagatc atggcaattg tcatgatttt gatcggaatg attttagtaa 1553641 caggacgctc gctgcaagaa acgctaaaaa agtggatgag cccgattgga cgttttataa 1553701 aagaacaatg gttagcattt attgatgaca tgaaatcctt caaatcaaat atgcagtcat 1553761 cgaaaaaaac gaaagcgccg agcaaaaaac aaaaaccggc ccgcaaaaaa cagcaaatgg 1553821 aaccggagcc tcctgatgaa gagggggatt atgaaacagt atcgcctctt attcattcag 1553881 agccgattat ctcaagcttt tctgatcgta atgaagagga agagtctcca gttatagaaa 1553941 agcgcgccga acctgtgtcg aagccgcttc aggacatcca accggagaca ggtgatcagg 1554001 aaactgtttc tgctcctcct atgaccttta cagagctcga aaataaggat tacgagatgc 1554061 cgtcactgga tttgctggca gatccgaagc ataccggcca gcaggctgat aaaaagaata 1554121 tttatgaaaa tgcgagaaag cttgaacgca cattccaaag ctttggcgta aaggcgaaag 1554181 tcacacaggt tcatctcgga ccggccgtaa caaaatatga agtatatcct gatgtcggag 1554241 tgaaggttag caaaattgtc aatttaagcg atgatttagc gcttgcgctt gctgcgaagg 1554301 atatcaggat cgaagcgcct ataccaggca aatcagcaat cggaattgaa gttccaaacg 1554361 cagaagtggc aatggtttcg ctgaaagaag tgctggagtc taaattgaat gacagaccgg 1554421 atgcgaagct gttaattgga ctcggccgca atatttcagg tgaagctgta ttggctgagt 1554481 taaacaagat gccccacctt ttggtcgcag gcgcaaccgg tagcgggaaa agtgtctgtg 1554541 tcaacggcat tattacaagt attttaatgc gggcgaaacc gcatgaagtg aaaatgatga 1554601 tgatcgatcc taaaatggta gagctaaatg tctacaacgg gattccgcat ttgcttgctc 1554661 ctgttgtaac cgatccgaaa aaagcgtcgc aggctttgaa aaaggttgtc aatgaaatgg 1554721 agcggcggta cgaattattt tctcatacgg gtacaagaaa tattgaagga tacaatgatt 1554781 atataaaacg cgccaacaat gaagaaggag cgaaacagcc agagctgcct tatattgttg 1554841 tcattgtgga cgagctagcc gatctcatga tggtcgcttc atctgatgtg gaagattcga 1554901 ttacgagatt gtcccaaatg gcgcgggctg ccggcatcca tcttattatt gcgacacagc 1554961 ggccatcggt ggatgttatc acaggggtga tcaaagcgaa cattccgtca cgaatcgcgt 1555021 tcagcgtatc ttcacagacg gattcaagga ccattcttga catgggtggc gctgagaagc 1555081 ttcttggccg cggcgatatg ctgtttttac ctgtaggggc taacaaacct gtccgtgtgc 1555141 agggagcatt tttgtcggat gacgaagtgg agaaggtcgt cgaccatgtg attactcagc 1555201 agaaagcgca atatcaagaa gaaatgattc ctgaggagac gacggaaact cattccgagg 1555261 ttactgatga actttatgat gaagctgttg aattaatcgt cggcatgcag acggcatctg 1555321 tttcaatgct gcaaagaaga ttcagaattg gctatacgag agcggcgcgc ctgattgacg 1555381 caatggagga acgcggtgtt gtcggaccgt atgaaggcag caaacctagg gaagtattat 1555441 tatcaaaaga gaaatatgat gagctctctt cttaatgaag ggagttccgc tttctatagt 1555501 tgtcaataat gatattatgt aaactgatca cctttctatt tattttttcg acaaaacatg 1555561 atatagttgt cccaattgtt caataatttt tatcgaaagt ggtttacgga ggggaaacat 1555621 gtctacaaaa gctgataatc ggcacttgta tttgaaagta attgaacgaa ttaaagagga 1555681 tataaaaaat gggatctaca ctgagaagga aaagctgcct tctgaatttg agctttccaa 1555741 aaagcttggt gtcagcagag cgacgctaag agaagccttg cggatactgg aagaagagca 1555801 tgtgattatc agaaggcatg gtgtaggcac ttttgtccat tctaagccgt tatttctttc 1555861 gggtattgaa cagctgaaca gtgtaaccaa gatgatagaa caggcgaata tgacccctgg 1555921 cacgattttt ctatcatcac aagtgcttat gccgtctgaa gatgatacga agagatttca 1555981 cttggcagaa gggcaagaac ttttttacct tgaacgagtc aggacagctg acggacagcc 1556041 gattgtgtat tgtatagaca aaattccgat gaatattttg ccgaattctt tttctcatca 1556101 gcaagaatct atgtttgacc tgctagagaa aaattcaggc tccgtaatca gctatgcagt 1556161 aactgatata gaaccgatcg gctatcacga taccatttct ccagtgcttg aatgcgatcc 1556221 ggaaacagct cttttgctgt taaaacaaac ccattacgat cagcacgata aaccggtgct 1556281 ttattcttta aattatttta gagcggataa attcagattt catgttttgc gtaaacgatt 1556341 ctaaaaacgg acgcctgtat gtgtctgttt ttttatttgc actgattcat gtttctttgt 1556401 acatactttc attccggtta acgcaatata taagggatga caagaaagtg aatgggtgaa 1556461 aatgttgaga gagaaaaatg gaatgaaaaa tattattgca ttgtcttctg tcccgcttgt 1556521 gatgacactc gggaactcca tgctgattcc tgttcttccg atgatggaga aaaagctgtc 1556581 tgtgacttca tttcaagtat ctttaatcat tactgtatat tcagtagtag caattatttg 1556641 cattccgatt gccggatatt tgtcggatcg tttcgggaga aaaaaaatat tgcttccatg 1556701 cctcctcatt gcaggattgg ggggagccgt agctgctttt gcctcgacct atatgaaaaa 1556761 tccttatgct atgatcttgg cggggcgggt tcttcaaggc attggttctg caggtgccgc 1556821 tccgattgtc atgccgttta tcggcgacct gtttaaagga gacgatgaaa aggtcagcgc 1556881 gggtcttggc gatattgaaa ccgccaacac gtcagggaag gtactgagtc ccatacttgg 1556941 agccttactg gcttcttggt attggtttgt accgttttgg tttattccgt ttttctgttt 1557001 gatcagcttt ttgctcgtat tgtttttggt ggccaagcct gaagaagatg aagatgcgcc 1557061 tgctgtttct gagtttatta agagtgtgaa gaaaattttt aaacaggatg gtcgctggct 1557121 ttatacggtc ttcattatcg ggtgtgtcat tatgtttttg ttatttggcg tattatttta 1557181 tttatcagat acgctggaga acaagtatgc tattgacgga gtagctaaag gcggattact 1557241 ggcaatccca cttttgtttt tgtcaaccag ttcttttata gctggcaaaa agatcggtaa 1557301 agataaaggc cgaatgaaat tttgcgttgt tacaggaatg attctgttaa ccctttcgtt 1557361 tattgccttg tggtggaacc acagttttta ttttttattt gtctttttaa gctttggcgg 1557421 gattgggatt ggaatggctc ttcctgcttt agatgcattg ataaccgaag ggattgaaag 1557481 tgaacaatgc ggaaccattt cctcctttta caatagcatg cgctttatag gagtagctct 1557541 cggtccacct gtttttgctg cattaatgtc taatgcaaac tggattattt tcatactctc 1557601 ggcgttttgc agcatcgttt ctttattttt agtgctcttt actgtagatg ctaaaaaaag 1557661 tgaagaagaa aaaaacttag ggacggtcta gccagccgtc tttttttgcg ctttcttgca 1557721 cagtttacaa ctgtacctat acagcatgcg gaggttattg tttccttata aatcctacag 1557781 ttgctataat tacatgaaag agtgtttctg cggatgctga aaattggtca taatacatac 1557841 taattaagaa atgaacgaag gaggttccat atgtcatatg ttaatgaact caaatcaaag 1557901 cacggcggtt taaccgcaca cattgtaaaa acagaaaaat tcaaaaccgt ctcgcttatt 1557961 tttaagatgc ttgcgccgct gacaaaggat caagtcacca aaagagcgct tctcccgcat 1558021 gtgcttcttc gcggaacgaa aagccatccg aaaaccgcag gattgcgttc atacttggat 1558081 gagctgtacg gcacgtcagt atcggctgat cttacgaaaa aaggagagcg gcatgtcatt 1558141 acgttcaggc ttgaaatccc gaatgaaaaa tatttaaaag accaaacgcc gcttctcgag 1558201 aaagggctcc agcttctcgc agaactcgtc ttttcacctg ctttggaggg agacgctttt 1558261 cagtcacaat atgtggctca agaaaaacgg acgcttaagc aaagaatcca agccgtctat 1558321 gatgataaaa tgcgttattc gaatttaagg ctgatacagg aaatgtgcaa aaatgatcct 1558381 tacgcgcttc atgtcaatgg tgaaatcgac gatgtcgatg acattacggc agagcaatta 1558441 tacgaaacat accaaagcgc tatccaaaaa gaccagcttg atctatatgt tgttggcgac 1558501 gtggacagta accaggtaca atcggcaatt gataagtatt tcaaaacaga agagcgcact 1558561 cttggcatga ttgaaaacaa tcacgctgat gaaaaagttc agccaaaaga agtaattgat 1558621 gaagaggatg tcaagcaagg aaaactgaat atcggctacc gcaccagcat cacttataca 1558681 gatcaggatt atcctgcttt acaagtgttt aacggattgt tcggcggatt ctctcattct 1558741 aaacttttca ttaatgttcg ggaaaaagcc agtcttgctt actacgcggc ttcgcgtata 1558801 gaaagtttta aaggcttgtt aatggtgatg tcaggcattg aagtgaaaaa ttttgaacag 1558861 gcggtttcga ttattgctga gcaattccag gcaatgaaaa atggcgattt cagtgagcag 1558921 gatatagcac agacaaaggc cgttattcga aatcaagtgc tggaaacgat tgatacagca 1558981 tacggtttat ctgagttttt atatcagcag gccgctgctc aagtcgagat tcctatcgaa 1559041 gactttcttg ccaatattga gaatgtcaca aaagaggata tcattaaagc cggcgaaaag 1559101 attcagcttg atacgactta tttcttaaaa gggacggagg gtgcatcttg atcaaaccaa 1559161 tcgaatatga acagcttcag gagacgctgt atcatgaaaa aatgtccaac ggccttgatg 1559221 tttacgtttt gccgaaaaaa ggcttcaaca agacatatgc ggtctttaca acaaagtacg 1559281 gctcgataga taaccggttt gtccctttag gtaaaaacga gatggttcac gtgccggacg 1559341 ggattgctca ctttcttgag cacaagctgt ttgagaaagc ggacggagac gtttttcaag 1559401 atttcagcaa acagggggct tctgccaatg cgtttacgtc atttacaaga acggcttacc 1559461 ttttctcaag cacatcaaat gttgaacgca atttagagac gcttatcgat ttcgtacagg 1559521 acccatattt tactgaaaaa acggttgaaa aggaaaaagg gattatcggg caggagatta 1559581 atatgtacga cgataaccct gattggaggc tttacttcgg ggtcattgaa aacatgtaca 1559641 aagagcatcc tgtcagaatt gacatagcgg gaacagtgga aagcatttca catattacaa 1559701 aagaccttct ttatgaatgc tatgaaacgt tttatcaccc gagtaacatg ctccttttca 1559761 ttgtcggccc tgtagatcct gaagcgatta tttctcaggt aagagaaaac caggggaaaa 1559821 agccgtatac tgatcagccg gagatcaaac gagaagaagt gaaagagcaa gaagcggttt 1559881 tccgaaaaga aaaagagatc aaaatgaacg tgcagggacc gaaatgcctt gttgggctga 1559941 aatccaaaaa tccgtttaaa ttaggcaaag agctcttaaa gcatgaactt tcaatgaact 1560001 tattgcttga agctcttttt ggcaaaagct ctgcccagta tgaatcactt tatgaaaaag 1560061 gatatattga cgaaacgttc agctttgatt ttactgctga atatgggttc ggttttgcgg 1560121 cgatcggcgg agatacgcct gagcctgatc aattggctga agacatttca agcatgcttt 1560181 tgcgcgccgg tgaactgatt actgctgaaa agattgaact tgccagaaag aaaaagatcg 1560241 gcacattctt aaaagcgctg aattcccctg aatacatcgc caatcaattt acccgttatg 1560301 cgttcttgga tatgagcctg tttgatgttg taacggtact cgagcagatt accctcgagg 1560361 atgtccagaa cgtaatacaa gaggaaatcg ctgcagacag actgactgtc tgcaaggttg 1560421 ttcctaaatc ataaacaaaa catccctcca gtgtgagggg tgtttttctg cggaaagaag 1560481 gaaagaggat gaacaaaaca gcactaatca ccggagcaag cggcggcatt ggcaaaagca 1560541 tcagcgaaac ccttgcagct agaggataca atctgctgct gcattacaat acaaatcaaa 1560601 acgcggcagc ggagcttgct gaaaaactaa gtcagatgtt tggcgtaaat gcggagatat 1560661 tacaagctga cctgtccgcg caagatggag cagataagct gacaagttca attgttcagc 1560721 cgattgatgc gattgtttta aacagcggac gaagccattt tgggctgatt acggatgtag 1560781 ataacgcaac ggtccaggaa atggttcagc ttcatgtggc gagtccgtat atgctgacga 1560841 gaaaccttct gccaggcatg attcggaata aatcgggagc gattgtggct gtcagctcga 1560901 tttggggaga gactggagca tcctgtgaag tgttgtacag catggcaaaa ggagctcagc 1560961 attcatttgt aaaaggattg gctaaggagc tggcgccaag cggaatcaga gtaaacgccg 1561021 tagcgccggg tgcagttgat acaaatatga tgaatcaatt taccccggct gaaaaagaag 1561081 agatcgctga tgagattccg atcggccggc tggcccggcc gcaagaaatt gcggatgcaa 1561141 cagcttttct cctgtctgaa aaagcgtcat atatcaccgg ccaaattctg tcggtgaatg 1561201 gcggctggca ctgctgatcc gaaaatattc ggtgtatagt ttcttttgcg aaggacacaa 1561261 taatcttgta acttcacatg aaatggagga aacaagcatg tcagtattag aaaactggga 1561321 tagctggaaa aacttccttg gcgaccgtct gaactatgcg caagataaag gtatgagcca 1561381 ggatacgatt acagatcttg cgacagaaat cggcagctac ttggctaatg aagtggaatc 1561441 taagaacgag caggaaaaag tgctggcaga tctttggagt gtagcatcaa aagatgaaca 1561501 gcacgccatt gccaatatga tggttaagct tgttgaaaat aacagcactc actaggaaga 1561561 gaggggattt ttcctctctt ttttatgttt tcctcatcac agcaacattc ttctttctaa 1561621 ttagagaaaa atgctttatg ataaaggaag gtaaaatttt gccacaatga agggggtata 1561681 tcatttggca aagctcgaat ggtattttga atatgaaatt caagtgaacc gccccggact 1561741 gctcggggat atttcatctc ttcttgggat gctttctatc aacatcgtaa cgataaacgg 1561801 cgtcgatctt tccagaaggg gaatgctcct caggtgccgc catatagatc aaattaaacg 1561861 attagaatca atcttaaaaa cgatggaaac aattaaagta acgaagctta gagaaccgag 1561921 gcttcgcgac cgtcttgccg tacgccacgg ccgttatatt caacgggatg ccgatgacaa 1561981 gaaaacgttc cgctttgaac gggacgagct tggcttatta gtcgatttta tggccgaatt 1562041 gttcaaaaaa gaaggccata aattaatcgg aatcagaggt atgccgcgtg tcgggaaaac 1562101 ggaatcgatt gtagcctcta gtgtgtgcga gcaaaaggtg gctgtttgtg tcatcaacct 1562161 tgctgaagca gacgataaga agccagctga ttgccgatga atacagcact gaaaatgtct 1562221 ttatcgttga cggaattgtg tcaacacgaa gagggtcaga acgccatctc cagctggtcc 1562281 gagaaatcat gcggctgcct gcaacaaaag tggtggagca tccggacata ttcgttcaaa 1562341 atacagagta tacactagat gactttgatt atattattga actgagaaat gaccctgatg 1562401 aggttattac atatgaacat gccgaggaac cccaaatgtt tgatcaatcc gggttttcaa 1562461 gctttgattt ttaaaattgg aaggtgtttg ttgtgactga actaggaatc cggctcaaag 1562521 aagccagaga ggaaaaagca atgtcattgg atgatctcca agcggcaaca aagattcaaa 1562581 aaaggtattt aaccgccttg gaggaaggaa actatgacat tattccgggg aagttttatg 1562641 ttcgggcatt catcaagcaa tatgcagaag ccgttgggct tgatgcggat cagctgtttg 1562701 aggagcataa aaaagatatc cctaatacgt atcatgatga tgtgtctgaa aagatctccg 1562761 gcatgaatct tcaaaaggaa atgccaaagc cagcatctaa ggcgctggag ctgctgccaa 1562821 caatacttgt tattctcggc gtgattgtcg tgattgccat tgtgtacgcg atcattcaat 1562881 ttgccaatca caaaaacagt gatgatcaca atgcggcatc agaaaaagca attacgcaaa 1562941 gtgagagcaa gtacgaaatc cctaaagatt caacgctgaa agagaatcaa aataacagct 1563001 ctgaaaaaga gacagacact aaaaaagaaa cgaaagaaaa cgaagataag aaaaaagaaa 1563061 atgacagtga gaagctggag attaaagctg ctggcactga aggatcgtta acgacttatg 1563121 aagtgtccgg cgctgataaa atcgagctgg aactgaaggc atcagacagc tcctggatta 1563181 gagtgcgcga tgaaaacagc agctctttaa aagaaggaac gctgaaaaaa gacgaaacct 1563241 ataaaaaaga cataactgat cagaaacaag ttgatatccg caccggatat gcacctaatc 1563301 tgaaaataaa aatcaacggt aaggttcttt catatgaact tgatccgaaa aaagtgatgg 1563361 cacaaaccat aaagattgta aataaaaagg aagaaaagtc atcttaatta ccagatgact 1563421 tttcttcacg tccgagtatg aaattggagg ggctttatgt ttaacttacc aaataaaatc 1563481 acactagcta gaatcgcatt aatcccaatc ttcatgatta tcatgctggc gccgtttgac 1563541 tggggcaggc tcgaagttgg agacgaatcc atcccggtcg cacatttggc gggggccatt 1563601 ctatttatta ttgcatctac aacagactgg gtggacgggt attatgcccg aaaattaaat 1563661 ctcgtaacaa acttcgggaa atttcttgat ccgcttgcgg acaaactgct cgtatccgca 1563721 gcgttaatta tccttgttca atttgatctc gctccagctt ggatggtcat tgtgattatc 1563781 agcagggagt ttgccgtgac aggtttaagg cttgtcttag ccggaacagg agaagtcgta 1563841 gctgctaaca tgcttggtaa aatcaaaacc tgggcacaga ttattgcggt atctgcattg 1563901 cttcttcata atcttccatt tgaacttgtg tcattcccgt ttgcagactt ggcgctgtgg 1563961 gtagccgtct tctttactgt cgtctcaggc tgggaatatt tctctaaaaa ttgggaagcg 1564021 ttaaaaacat ctaactaaga aagaaggact tcgtcatgga atttccaaaa aaagcagaaa 1564081 taattgcagt cggttcagag ttgctgcttg gtcaaatcgc caatacaaat gctcaattta 1564141 tcagcaaaca gctcgctgaa atcggggtca acgtatttta tcatacagcg gtcggagata 1564201 acccggagcg gctgaagcag gtcatccgca ttgctgaaga acgctctgac ttcattattt 1564261 tttcaggagg gcttggaccc acaaaagatg atctgacgaa agaaacgatt gcaaatacgc 1564321 tgggacgtcc gcttgtgtta aatgatgagg cattccaatc cattgaggac tatttcaaac 1564381 gaacaaaacg cacgatgtca cctaataacc gaaaacaggc gcttgtgatc gaaggctctg 1564441 acgtgctggc gaatcacttt ggaatggccc cgggaatgct cacagagcat gaatcgcgct 1564501 attatatgct tcttcctgga ccgccgagcg aattgcgtcc aatgtttgaa aacgaggcaa 1564561 agcctcttct gctgaaaaag atgggttcaa atgaaaaaat tgtgtcaact gttcttcgct 1564621 ttttcggtat cggtgaatct cagcttgaag ccgatttgga agatattatt gatgcacaaa 1564681 ccaatccgac aattgcgcct ttggcggctg atggagaggt gacgctgcgt ctgacagcca 1564741 aacacgccga tgaaaaggaa acagagcgtc tgttaaaaga aacagaggcc gttatcttag 1564801 agcgtgtcgg tgaatttttc tatggttacg atgatacttc tcttgtaaaa gagctatcta 1564861 tagcatgtaa ggaaaaaggc ataacaattt ctgcggcaga aagctttacc ggagggctgt 1564921 tttctgaatg gctgacggat catagcggtg cctcaaaatt atttgccggg ggcgttgttt 1564981 gctatacaaa cgacgtgaag cagaatgtgc ttggtgtcaa gaaggaaaca ttagatcgtt 1565041 ttggggcggt cagcaaggag tgcgcatccg aactggctaa gggtgttcaa aaactcactg 1565101 gcagcgatat cggcattagc tttactggtg tagcaggacc tgatgctcaa gaagggcatg 1565161 agcctgggca tgtgtttatc ggcatttccg caaatggtaa agaagaggtt cacgagtttc 1565221 actttgcggg ctccagaacg gggatcagaa aacgcggcgc taaatacggc tgccatttaa 1565281 tcttaaagct tttagagcaa aaataatatt ttcagcacat tatcctccta agaaaacatg 1565341 atttctctga tacattatga tattttgata ggaatcacgc caagaaaaaa tccgaatatg 1565401 cgttcgcttt tttcttggca aatcccttca aacagggtat agtatatgta gtggtaacat 1565461 aaaggaggaa aaaatagaat gagtgatcgt caggcagcct tagatatggc tcttaaacaa 1565521 atagaaaaac agttcggcaa aggttccatt atgaaactgg gagaaaagac agatacaaga 1565581 atttctactg taccaagcgg ctccctcgct cttgatacag cactgggaat tggcggatat 1565641 cctcgcggac ggattattga agtatacggt cctgaaagct caggtaaaac aactgtggcg 1565701 cttcatgcga ttgctgaagt tcagcagcag ggcggacaag ccgcgtttat cgatgcggag 1565761 catgcgttag atccggtata cgcgcaaaag ctcggtgtta acatcgaaga gcttttactg 1565821 tctcagcctg acacaggcga gcaggcgctt gaaattgcgg aagcattggt tcgaagcggg 1565881 gcagttgaca ttgtcgttgt cgactctgta gccgctctcg ttccgaaagc ggaaattgaa 1565941 ggcgacatgg gagattcgca tgtcggttta caagcacgct taatgtctca agcgcttcgt 1566001 aagctttcag gggccattaa caaatcgaag acaatcgcga ttttcattaa ccaaattcgt 1566061 gaaaaagtcg gtgttatgtt cgggaacccg gaaacaacac ctggcggccg tgcgttgaaa 1566121 ttctattctt ccgtgcgtct tgaagtgcgc cgtgctgaac agctgaaaca aggcaacgac 1566181 gtaatgggga acaaaacgaa aatcaaagtc gtgaaaaaca aggtggctcc gccgttccgt 1566241 acagccgagg ttgacattat gtacggagaa ggcatttcaa aagaaggcga aatcattgat 1566301 ctaggaactg aacttgatat cgtgcaaaaa agcggttcat ggtactctta tgaagaagag 1566361 cgtcttggcc aaggccgtga aaatgcaaaa caattcctga aagaaaataa agatatcatg 1566421 ctgatgatcc aggagcaaat tcgcgaacat tacggcttgg ataataacgg agtagtgcag 1566481 cagcaagctg aagagacaca agaagaactc gaatttgaag aataaaaata aaataagttt 1566541 caaatgatac aaaaggctga gtgaaaaact cagctttttt gtattttgca aaaaaatgat 1566601 aaaaatattg ctttttttga caactttttt agggctttat tcgtctaaca aaacgtgtgc 1566661 aaaatggaat ttattttggg aggaaaaaat gaatgacaag cccaacccgc agaagaactg 1566721 cgaaacgcag acggagaaaa ctaaataaaa gaggaaaact gttgtttggt cttttagcag 1566781 tgatggtttg cattacgatt tggaatgctc ttcatcgaaa tagtgaagaa aacgaaccat 1566841 ctcaagaaac tgcagcggtt tcaaataccg atcagaaaaa agaggtcaaa aagaaaactg 1566901 ccaaaaaatc agaggaacaa atcaaaacag tggatcgaaa ccaaaaaatc agcaattatt 1566961 taaaagagat cggtttcagc ggaacagcca tgattgtcag aaatggagaa atcgtaacaa 1567021 ataaaggttt tggctatgct gaccgtaaac actacattca aaataatcca ttgacatctt 1567081 tttatgtcgg ttcatcacaa aaagcgctga ttgcaactgc tattttgcag cttgaggaaa 1567141 aggggaaact tcagacaagt gatccggtaa gcacgtattt acctcatttt cccaacggac 1567201 aaacgattac tttgaagaat ctgcttacac atacatcggg gataaacgga catattgaag 1567261 gaaacggcgc cattactccg gacgatttaa taaaagatat agaacttcag ggaatcaaac 1567321 gtcagccggg cgtatgggac tacaaggatt ccaactattc tgttcttgct tatattattg 1567381 ctgaagtaag cggtgagccc tatgaacagt acataaagaa tcatattttt aaacctgcgg 1567441 gaatgacgca tgcaggcttt tacaaaacat atgaaaaaga accttatcct gccgtcgggt 1567501 ataagatgga gggcagcaaa acagttacac cgtatatacc tgatttatcc cagctgtatg 1567561 gagcgggtga tatttatatg agcgctatag atatgtacaa atttgaccaa gcgctgatag 1567621 acggaaaact gtattcgcaa aaaagctatg aaaagatgtt tacgccaggg agcagctcca 1567681 catacggcat gggattttat gttgctcccg gaagctattc aaaccatggt gttatgccgg 1567741 gcttcaatat cttgaacagc tttagcaaat ctgggcaaac cattgttatt ttgttctcaa 1567801 acattcaaaa taatgctaaa ttgggccaag tgaacaataa aatataccag cttctaaatc 1567861 aagaatgatt ggcgatcttc ttttggatga attgcattcg gcacgtgaaa agaagactgg 1567921 cctgcaaacg ttaagatggc aagcttgaca agtatttccg acacatttac aatgaagttg 1567981 taacatttgt ttttttaaca tgattgttaa accatttaaa cttgacaagg gcgatgaaca 1568041 cactcattcc ctgtgaaggt tctgtatgtt gagaaaacta gacaatgtac atgccgacac 1568101 tttttaagca acaaccaagt tcatagcaag aggaggtgaa agtatgaccc caattatgat 1568161 ggttctcatc tccattttgc tgattctact cggtttagtt gttggctact ttgttcgtaa 1568221 aaccattgcc gaagcgaaaa ttgcgggcgc acgcggtgca gccgagcaaa ttcttgaaga 1568281 tgcgaagcgt gatgctgaag cactgaaaaa agaagctctg cttgaagcaa aggatgaaat 1568341 ccacaaactt cgaatagatg ctgaacagga agttcgtgaa agacgaaatg agcttcaaaa 1568401 acaagaaaac cgtttactcc aaaaggagga aaaccttgat cgcaaacatg agggaattga 1568461 taaacgggaa gcgatgttgg agaagaaaga tcattctctg aatgaacgac aacaacatat 1568521 tgaagagatg gaaagcaaag tggatgagat gattcgtatg cagcagtctg agttggaacg 1568581 aatttcgagt ctgactcgtg acgaagcgaa acaaatcatt cttgagcggg ttgaaaacga 1568641 gctttcacat gacatcgcca tcatgacaaa agaaactgaa aaccgtgcga aagaagaggc 1568701 ggataagaaa gcgaaaaaca ttctttcact cgccttacag cgctgcgcag cggaccacgt 1568761 tgccgaaaca acggtatcag ttgtcaatct tccaaatgat gagatgaaag gacgtatcat 1568821 cggacgggaa gggcgtaaca ttcgtacgct tgaaacgctg acaggaattg acctgattat 1568881 tgatgatacg cctgaagctg tcattctttc cggatttgat ccgatcagac gtgagacagc 1568941 cagaattgct cttgataaac tcgttcagga tggccgtatt catccggcac ggattgaaga 1569001 aatggttgaa aaatctcgcc gcgaggtcga tgactatatt cgtgagatgg gtgagcaaac 1569061 gacatttgag gttggcgttc atggcctcca cccagatctc atcaagatcc tcggccgctt 1569121 aaagttccgt acaagctacg gtcaaaatgt gcttaagcat tccatggaag tcgcattctt 1569181 ggccggtcta atggcatcgg agcttggtga agacgcaaag cttgctaaac gtgcgggtct 1569241 tcttcacgac atcgggaaag caattgacca tgaagtagaa ggaagccacg ttgagatcgg 1569301 ggtagagctt gcgaccaaat ataaagagca cccagtcgtg attaacagta ttgcatcaca 1569361 ccacggggac gaggagccga cttccattat tgctgtactg gtagctgcag cagatgcgct 1569421 ttccgctgca agacctggcg caagaagtga gacgctcgag aattatattc gaagacttga 1569481 aaaacttgaa gaaatttctg agtcctacga aggtgttgaa aaatcatttg ccattcaggc 1569541 tggacgcgaa gtgcgaatta tggtgaagcc ggattcaatt aatgatcttg aggctcatcg 1569601 actggcgcga gatatccgca agcgaattga ggacgagctc gattatccag gtcatattaa 1569661 ggtgacagta atcagagaga ctcgagccgt agagtatgca aaataaagtg atgcgctaag 1569721 catcacttta tttttttgac ggcaaggaat tttcaagaag aaaggattta caaaatgaga 1569781 attttattta tcggagatgt tgtcggttca ccgggccgtg acatggtcaa agaatatgta 1569841 ccaaagctaa aaacaaaata taagcctcac tttaccatta ttaatggtga aaacgccgca 1569901 catggaaaag gcctgacgga aaaaatttat cacagcttaa tccagtccgg cgcagatgca 1569961 atcacaatgg ggaaccacac atgggacaaa aaagaaatat ttgattttat agatgacgtt 1570021 ccgaacttgg ttcgcccggc aaactttcct gaaggaacac cggggaaagg gatcacatat 1570081 gtgaaagcaa acggcaaaga actagcagtc attaatttgc agggacgtac gtttttgccg 1570141 ccgcttgatg acccgttttt aaaagcggat gaattgatcg cagaagctgc gaaaagaaca 1570201 ccgtacattt ttattgactt tcatgccgaa gcgacaagtg aaaagctcgc acttggctgg 1570261 tacacggatg gacgggcatc ggctgtagta ggaactcata cacacgtgca aacagcggat 1570321 aaccgcattt tgccgaaggg aacggcatat attactgatg tgggaatgac tggcccgtat 1570381 gacggtatac tggggatgga cagagagacg attattaagc gattcaaaac gaaccttcca 1570441 gtccggttta ctgtcgctga aggaaaaaca acgctcagcg gagttgtcat tgacattgac 1570501 gatcaaacga aaaaagccgt gaaaattgag cgtattttaa tcaacgatga tcacatgttc 1570561 tttgaatagt tgaacatatg gttattttat aaaaatatta aaaagaaaag caggaatata 1570621 gcaactcctt agtgaatata gtaaaaatgg aaggtagccc gctatttttg aaaagcattg 1570681 tggggatggc tttttggata gcaacatcta ataatgattg ttctaatgaa cactcactta 1570741 tccattgtaa aactaagggg gagcagaaat ggaaatctta aaagtttcag caaaatcgag 1570801 tccaaattca gtggcaggtg cgcttgcagg cgtgttgaga gagcgaggag ccgccgagat 1570861 tcaagcgatc ggagcgggtg cattaaacca ggctgtaaaa gctgtggcga ttgccagggg 1570921 atttgtggcg ccaagcggcg ttgatttgat ttgtattccg gcttttacag atattcaaat 1570981 cgatggggaa gaaagaacag cgattaaatt aatcgtggag cctcgctaaa aacaaataaa 1571041 gcattctcaa cctgtttgcg taatgcaaac aggttgtttt tcatttattg tgatattttc 1571101 tcccgatagt atttttagca cataaatgag cgaatataca aaatcagaaa tgagctaaaa 1571161 cgtttcaaaa aaaatttccg cccatttttc aagacagata cttttgtcct tctggaaaag 1571221 acagttctgt ttacgcttat tccatatcat ggtacaatcc gaatataaca agaatttttc 1571281 aaggaggatt gtacatgcag agtggaaaga tgaaagctct aatgaaaaag gacggggcgt 1571341 tcggtgctgt gctgactgaa gttcccattc ctgagattga taaacatgaa gtcctcataa 1571401 aagtgaaagc cgcttccata tgcggcacgg atgtccacat ttataattgg gatcaatggg 1571461 cacgtcagag aatcaaaaca ccctatgttt tcggccatga gttcagcggc atcgtagagg 1571521 gcgtgggaga gaatgtcagc agtgtaaaag tgggagagta tgtgtctgcg gaaacacaca 1571581 ttgtctgtgg tgaatgtgtc ccttgcctaa caggaaaatc tcatgtgtgt accaatactg 1571641 ctataatcgg agtggacacg gcaggctgtt ttgcggagta tgtaaaagtt ccagctgata 1571701 acatttggag aaatcccgct gatatggacc cgtcgattgc ttccattcaa gagcctttag 1571761 gaaatgcagt tcataccgta ctcgagagcc agcctgcagg aggaacgact gcagtcattg 1571821 gatgcggacc gattggtctt atggctgttg cggttgcaaa agcagcagga gcttctcagg 1571881 tgatagcgat tgataagaat gaatacaggc tgaggcttgc aaaacaaatg ggagcgactt 1571941 gtactgtttc tattgaaaaa gaagacccgc tcaaaattgt aagcgcttta acgagtggag 1572001 aaggagcaga tcttgtttgt gagatgtcgg gccatccctc agcgattgcc caaggtcttg 1572061 cgatggctgc gaatggcgga agatttcata ttctcagctt gccggaacat ccggtgacaa 1572121 ttgatttgac gaataaagtg gtatttaaag ggcttaccat ccaaggaatc acaggaagaa 1572181 aaatgttttc aacatggcgc caggtgtctc agttgatcag ttcaaacatg atcgatcttg 1572241 cacctgttat tacccatcag tttccattag aggagtttga aaaaggtttc gaactgatga 1572301 gaagcgggca gtgcggaaaa gtaattttaa ttccataaag ggggataaac atgacgaagg 1572361 aatttgagtt tttaaaagca gagcttaata gtatgaaaga aaaccataca tggcaagaca 1572421 taaaacagct tgaatctatg cagggcccat ctgtcacagt gaatcaccaa aaagtcattc 1572481 agctatcttc taataattac ctcggattca cttcacatcc tagactcatc aacgccgcac 1572541 aggaggccgt tcagcagtat ggagccggca ccggatcagt gagaacgatt gcgggtacat 1572601 ttacaatgca tcaagagctt gagaaaaagc tggcagcctt taaaaaaacg gaggcggcac 1572661 ttgtattcca atcaggcttc acaacaaacc aaggcgtact ttcaagtatt ctatcaaaag 1572721 aggacattgt catctcagat gaattgaacc atgcctctat tattgacgga attcgactga 1572781 caaaggcgga taaaaaggtg tatcagcacg tcaatatgag tgatttagag cgggtgctga 1572841 gaaagtcaat gaattatcgg atgcgtctga ttgtgacaga cggcgtattt tccatggatg 1572901 gcaacatagc tcctctgcct gatattgtag agctcgctga gaaatatgac gcatttgtga 1572961 tggtggatga cgcccatgca tccggagtac ttggcgaaaa cggcagggga acggtgaatc 1573021 acttcggtct tgacggcaga gtgcatattc aggtcggaac attaagcaag gcaatcggag 1573081 tgctcggcgg ctacgctgca ggttcaaagg tgctgatcga ttatttgcgc cataaaggcc 1573141 gtccattttt attcagcaca tctcatccgc cggcagtcac tgcagcttgt atggaagcga 1573201 ttgatgtctt gcttgaagag ccggagcata tggagcgctt gtgggagaat actgcctatt 1573261 ttaaagcaat gcttgtgaaa atgggtctga ctctcacgaa gagtgaaacg ccgattcttc 1573321 ctattttaat aggtgatgaa ggtgtggcaa agcaattttc agatcagctc ctttctcgcg 1573381 gtgtttttgc ccaaagtatc gttttcccga ctgtagcaaa gggaaaagcc agaattcgca 1573441 cgattataac agcagagcac accaaagatg aactggatca ggcgcttgat gtcatcgaaa 1573501 agacggcaaa ggagctccag ctattgtaac aagaggaaga gtttactctt cctcttttga 1573561 ttccttattg attattattc tcaatgagtg tacaatgata ggttgccagt tgtgcagagc 1573621 ttcaataacc tttatactga agggtggaag tttggtttga aaggagaaaa tatgacatga 1573681 atgaaaaaca aaaattagag agcggacaag ttcatccatc ggacaaaaaa tccgagaagg 1573741 attacagcaa gtactttgaa gctgtttaca ttccgccttc tttaaaagac gcgaaaaaac 1573801 gaggcaagga agccgttact tatcataatg actttaaaat ttctgaacaa tttaaaggat 1573861 tgggagacgg aagaaagttc tatatccgta cgtacggctg ccaaatgaat gaacacgata 1573921 cagaggttat ggcagggatc tttatggcgc tcggttacga agcgacaaac tctgttgacg 1573981 atgccaatgt cattttgtta aatacatgtg caatccgtga aaatgctgaa aacaaggtgt 1574041 ttggtgagct cgggcactta aaagcactga aaaaaaacaa tcccgatctg attttaggcg 1574101 tgtgcggctg tatgtcccaa gaggaatcag tcgtgaaccg tattttgaaa aaacatccgt 1574161 ttgtcgatat gattttcgga acgcataaca ttcatcgcct gccggagctt ttgtcagaag 1574221 catacctttc aaaagaaatg gttgtagaag tttggtctaa ggaaggggac gttattgaaa 1574281 accttccaaa agtccgaaat ggaaaaatta agggctgggt caatatcatg tacggctgtg 1574341 acaaattctg tacgtattgc attgtgcctt acacacgcgg aaaagaaaga agccgccgcc 1574401 ctgaggatat cattcaggaa gtgagaaggc tcgcaagtga aggctataag gaaattactc 1574461 tgttaggcca aaacgtaaac gcgtatggaa aagactttga agatatgacg tacggacttg 1574521 gtgatttgat ggatgaactg agaaaaatcg atatcccgag aatccgtttt acaacgagtc 1574581 atccgcgcga ctttgacgac cgcctcattg aagtgctggc aaaaggcgga aatctgcttg 1574641 atcacattca tcttccggtt caatcaggaa gctcagaagt tctcaagctg atggcccgca 1574701 aatatgacag agagcgttac atggagctgg tgcgaaaaat taaagaagca atgccaaacg 1574761 cttctttgac aacggacatt atcgtcggat ttccaaatga aacggacgaa cagtttgaag 1574821 aaacgctttc tctataccgt gaagtggagt ttgacagcgc ctatacgttc atttactctc 1574881 cgcgtgaagg cactccggct gctaagatga aagataatgt accgatgcgt gtgaaaaaag 1574941 aacgcctgca gcgtctaaac gcactggtga atgaaatttc tgctaaaaaa atgaaggaat 1575001 acgaaggcaa ggttgtcgaa gtattagttg agggtgaaag caaaaataac cctgatattc 1575061 ttgctggcta tactgaaaaa agcaagcttg tcaatttcaa agggccgaag gaagccatcg 1575121 gcaaaatcgt ccgcgtgaaa atccagcaag cgaaaacatg gtcgcttgac ggagaaatgg 1575181 taggagaagc aatcgaggtg aaatgagatg acgctctact caaaaaaaga cattgtgcag 1575241 caggctcgaa accttgcaaa aatgatttct gaaacagaag aggttgattt tttcaaacgg 1575301 gctgaagcgc aaatcaatga gaatgacaaa gtgtccacaa tcgttaatca gattaaagcc 1575361 ctgcaaaagc aggctgtcaa tctgaagcat tatgaaaagc atgaagcgct caaacaagta 1575421 gaagcaaaaa ttgacgcgct gcaagaagag cttgaagaga ttcctgttat ccaggaattc 1575481 agagactcgc aaatggaagt aaatgaccta ctgcagctcg ttgcacacac catttccaac 1575541 caagtcacaa atgaaatcat cacatcaacc ggaggcgacc tgctgaaagg ggaaaccggt 1575601 tcaaaggtga agcattcaaa taacagctgt tctctctaaa cacggtgcct ttacaggccc 1575661 gtgttttttt atcatttgtg cggttaaaaa tgaactaaat aatctatgta ccaaatgttc 1575721 aattggtttt tctgtgctca gccgcgtata aactttatcg cacttataag taaagtttct 1575781 aggcacccct gcatacaatg gaacagaaac tttgtatttt tatattttat ttataaaaat 1575841 gcacactaga caaatgccca gcataagata acacgaagaa gaacaaggag gcatgccgga 1575901 atgtctgaat acagggaaat tattacgaag gcagtagtag cgaaaggccg aaaattcacc 1575961 caatgcacca acaccatctc gcctgagaaa aaaccgagca gcattttggg tggttggatt 1576021 attaaccaca agtatgacgc tgaaaaaatt ggaaaaacgg tagaaattga agggtattat 1576081 gatataaacg tatggtactc ttacgcggac aacacaaaga cagaggttgt cacagaacgg 1576141 gtaaaatatg tagatgtcat taaactcaga tacagagaca ataattactt agatgatgag 1576201 catgaagtga ttgccaaagt gcttcagcag ccaaactgcc ttgaagtgac catttcgccg 1576261 aatggaaata aaatcgttgt gcaggcagaa agagaatttt tggcggaagt ggtaggggaa 1576321 acaaaggtag ttgttgaggt caatcctgac tgggaagagg atgacgagga agattgggaa 1576381 gatgagcttg atgaagagct tgaagacatc aacccggagt ttttagtggg agatcctgaa 1576441 gaataaaaaa gggactaggg gagacagtac ccccaagtct cttttttata ttgatatatc 1576501 attcttttat cactttttgt ttatgttata atgaaggttg gaaaatagaa acgttgatac 1576561 atagtgaggg attaaacaat ggccggttat acgcctatga tacagcaata tttaaaaata 1576621 aaggcagagc accaggatgc ctttttattt tttcgcctgg gtgattttta tgaaatgttt 1576681 tttgaggacg ccaaaaaagc gtcacaagag ctggaaatta cgttaacgag cagagacggc 1576741 ggtgcggctg aaaaaatacc gatgtgcggt gtgccgtatc attctgcttc cgcgtatatc 1576801 gaacagctta ttaaaaaagg atacaaagtg gcgatctgtg aacagacgga agatccgaaa 1576861 gccgcaaagg gcgttgtgaa aagagaagta gttcagctga ttacgcccgg aactgtaatg 1576921 gacggcaaag gcatccatga gtcggaaaat aattttatcg catctgtttc agcctgctcg 1576981 aacggatacg gacttgctct gtctgattta acaacgggag aaaatttggc tgttttgatt 1577041 gaacggcttg aagacgtcat atcagaaatt tattcagtcg gcgcacggga aatcgtggtt 1577101 tcaggaagct tggatgccga tacagtggca cagctgagag agcggtgcgg tgcaacgatt 1577161 tcaattgaag acggagaaac agacgaacac gtaacgatca ttgagcactt aaataatgaa 1577221 gatataacaa aaacatttct gcgcttatat acgtatttga aaagaaccca aaagcgcagc 1577281 cttgatcatc ttcagcccgt gcaggtgtat gagcttgagg aagcgatgaa aattgacttg 1577341 tactcaaagc gtaatctgga gctgaccgaa acgattcgtt cgaaaaataa aaaaggctcc 1577401 cttttgtggc tgctggatga aacaaaaacg gcaatgggag gccggctact taaacagtgg 1577461 attgaccggc cgcttatcag agtcaatcaa atcgaagagc gccaagaaat ggtggaaaca 1577521 ttaatgtccc atttctttga acgggaagat ctgcgtgaac gtttaaaaga agtatatgac 1577581 ttagaacgcc ttgccggccg cgttgcattc ggaaatgtca atgcccggga tttgattcag 1577641 ctgaaggaat cgttaaagca agtgcctggc atcaaacagc tggttgcttc actggctcat 1577701 gacaaggcca aggaacgtgc aaagcgcatt gacccttgcg gggatgtact tgaactgctg 1577761 gaagaagcgc tgtacgaaaa ccctccttta tcggtaaaag aagggaacct gattaaagat 1577821 ggttataatc aaaagcttga tgaatatcgt gatgcaagca gaaacggaaa agactggatt 1577881 gcccgcctgg aacagcagga gcgggaatac acaggcattc gctctttaaa ggtcggcttt 1577941 aataaagttt tcggttatta cattgaagtg acaaaagcaa acttgcattt gcttgaggaa 1578001 gggcgttatg agcggaagca gacgttaacc aatgcagagc gctacattac acctgaatta 1578061 aaagaaaaag aagcgctcat tttagaggcg gaaaataaca tctgtgagct ggagtacgag 1578121 ctgtttaccg agctgcgcga gaaagtgaag cagtatattc cgcggctgca gcagcttgca 1578181 aaacagatga gcgagctgga cgcactgcaa tgctttgcga caatcagtga aaatcgccac 1578241 tacacgaaac cagagttctc taaagatgaa gtcgaagtga ttgaaggcag acacccggtt 1578301 gttgaaaaag tcatggacag ccaggaatat gtcccgaaca actgtatgat gggcgataac 1578361 agacaaatgc ttctcattac aggtccaaac atgtcaggga aaagcacgta tatgagacaa 1578421 atcgcgctca tttccattat ggcgcaaatc ggctgctttg tacccgcgaa aaaagcggtg 1578481 ctcccgattt tcgatcaaat ttttacgcga atcggcgctg cagatgattt gatttccgga 1578541 caaagtacat ttatggtaga aatgcttgaa gcgaaaaatg cgattgtcaa tgcgacgaaa 1578601 aacagcctca ttctgtttga tgaaatcggg cggggaacgt ccacttatga cggcatggcg 1578661 ctggcacagg cgattattga atatgttcac gatcatatcg gcgccaagac gctgttcagc 1578721 acacactatc acgagctgac cgttcttgag gacaagctgc cccagctgaa aaacgttcat 1578781 gttcgcgctg aagaatataa cggaacggtt gtctttcttc atcaaattaa agaaggtgcg 1578841 gctgataaaa gctatggtat ccatgtagct cagcttgccg aactgccggg agatctgatt 1578901 gcgcgcgctc aagatatttt aaaagagctt gagcattcag gaaacaaacc ggaagtgccg 1578961 gtgcagaaac ctcaggtgaa agaagagccg gcacagctgt ccttttttga cgaagcggaa 1579021 aagccggctg aaacaccaaa gctttcaaaa aaagaaaagc aagtgatcga tgctttcaaa 1579081 tcacttaata tactggatat gacaccgctt gaagcgatga atgaaatgta caagctgcaa 1579141 aagaaattac attaaaacgg ggtgatgaat gtggcaaaag tcatccaact gtcagatgag 1579201 ctttcaaata aaatagcggc gggcgaggtt gtggaacggc ccgcctcagt cgtcaaagaa 1579261 ttggtggaaa atgcgatcga cgctgacagc acagtcattg aaatcgatat tgaggaagca 1579321 ggccttgcat ccattcgggt cttggataac ggcgaaggaa tggagaatga agattgcaag 1579381 cgagctttcc ggcgccacgc aacgagtaaa ataaaagatg aaaatgattt attcagggtg 1579441 agaacgctcg gtttcagggg agaagccctg ccgagtatcg cgtcagtctc tcatctggag 1579501 attacaacaa gcactggtga aggagctggg acgaagctcg tcctccaagg aggaaacatc 1579561 atttccgaat cgcgttcctc aagcaggaag ggaactgaaa ttgtcgtttc caacctgttt 1579621 tttaacacac cggcccgttt gaaatatatg aaaaccgttc atacagagct tggaaacatt 1579681 acagatgtgg ttaaccgtat tgctctggcg catccagagg tatcgatccg cctgcgccat 1579741 catgggaaaa acctgcttca aacgaacgga aacggagatg tgcgccatgt actggcagcg 1579801 atttacggca cggctgtcgc caaaaaaatg cttccgctgc atgtgagctc cttggatttt 1579861 gaagtaaagg gatatatcgc cctcccagag attacacggg cgtcgagaaa ctatatgtcg 1579921 tctgtggtca atggccgtta cattaaaaat ttcccgctcg tcaaagcggt tcatgaaggc 1579981 tatcatacgc ttctgccgat cggacgccat ccgattactt ttatagaaat tacgatggac 1580041 ccgattttag tcgatgtcaa cgtgcatcca tcgaagcttg aggtccggct cagcaaggaa 1580101 acagagcttc atgacttaat acgtgacgga attaaagatg tgtttaaaca gcagcagctg 1580161 attcctagtg cccaggtccc gaaaaaatca gcacctgcca tcaaaaatga gcagcagttt 1580221 ataacctttg atgaaaagcc tccggaaaaa aaagttccgg aaaaatcgac tgcgccatct 1580281 tattcaccga tgaagctcag ctcagtcgta aaagagccgg ttgatgcgga ggaaaaattg 1580341 ccccctctcc aatttgatgc tcctcctatc gttgatcagg aacaaaccct tgaggtgtcc 1580401 gatgtttcag cagaacagcc tgaaacattt gagcaggaat gccatgagga acagccgcag 1580461 ccagcgtctg atcgggttcc aattatgtac ccgattggcc agatgcacgg gacttatata 1580521 ttggcacaaa acgaaaacgg cctatatatt atcgaccagc acgccgccca agaacgtatt 1580581 aaatatgagt acttccgtga aaaggtgggg gaggttgagc ctgaggtgca ggagatgatt 1580641 gtaccgctga cgttccacta ctccacaaat gaggctttga ttattgaaca gcacaaacaa 1580701 gagctcgaaa gcgtcggtgt ctttttagag tcattcggct ctaacagtta catcgtccgc 1580761 tgccacccag cctggtttcc aaagggagaa gaagcagagc ttatagaaga aatcattcag 1580821 caggtgctcg actccaaaaa tatagatatt aaaaaacttc gcgaggaagc ggcgattatg 1580881 atgagctgca aaggctccat caaagcaaat cgccacctca gaaacgacga aatcaaagcg 1580941 cttctggacg acctccgaag cacatcagac ccatttacat gcccgcacgg ccgcccgatc 1581001 atcattcacc actcgacata tgagatggaa aagatgttca aacgcgtgat gtagcggggg 1581061 tggtaggcat tgatccattc tctgaatgga tcaatgcttt ttttgtactc cttcgagtgt 1581121 cagattataa gaaacggttg taaacgtgtg agcagtgtta acgcattata cttcatggtt 1581181 cctccgtata acaaaatttc catttacagg caattgggat taatgtatat tttgggtgag 1581241 ggggtggaaa catatggcat gtggtccgaa gatcattatc tttttggatg aacttgatga 1581301 tccaaatgtg agaatcattt tagaatgcag aatttaaatt acaacattgt gttttgctcc 1581361 ctgttcgtgt gaacagggag attttttcgt ttatataact ggtgatgtcc aaatataggg 1581421 tgttatgaat tttccatatc tgccatcggc tttaagctgc ttctctatta ggctggttat 1581481 caaaagcaag ttcaatgata gccatgaaag ctgatatcac aacaagcaag acatctggaa 1581541 tataaataga ctgcataaag taatctgcaa aacagatcgt tataagattg ctgataaaat 1581601 acagtataaa agcaaaaagt gcagtctttt tcaatgaaag tgattttgcc aaaatgatag 1581661 agataatctt tgtgagtggg tctatgatta aacctacagc aaagcaggct aaaataaata 1581721 aagctaatgt ttgattggaa gcgtatgtga tgccaagtat ggagaataag cctttcatcc 1581781 cgaagaaaaa gccgccgaag atgactgcaa gcgcgatggc cgcgataaaa gtaatagata 1581841 caattccgat taattttgat ctcaggttaa aatctttaga gtgctcgttc tgttcttttt 1581901 ggttcatgta tgacactccc ttcacctgct tactcataca aacagcaccc ttgaatcagc 1581961 ccaaaatatc tataagtctg ttttctgacg aaaatagtat agcatatttt aacaaaacca 1582021 aaaaaggccc tttccactgg ggaagggcct ttttcatcat gttaactcct gagattcgcc 1582081 gaagctttct ctttttttgg ccaaataaaa tagctggctg taatgagaaa gtcaatgcct 1582141 ataatgacag tccacagttt aagaatgccg ctcaacgcct cggttcggga agagtcattg 1582201 ataaaataga tcatccctgc caatagtccc gcaccaatta agtaggccag cacatgtctt 1582261 agccagcctt tcgcaccgtg cttggcatgg tccattccaa aacgtttcag cggttttgtt 1582321 cctttttttg tcacataata ttgaaacttt tcatctgccc attgaatcat ttgtttccca 1582381 taagcgatcg atataccgat gtaaacagct gcaatcccat gggctgcggt cgctgaggct 1582441 ccgcggtaaa ggtccacacc agttgccgct aacaagatca aatcgataac tggagttaag 1582501 gcaaggaata gcagtcctaa tgtatgtcgt ttgaatacgt agcgtacagc aagccccaaa 1582561 acaatgacaa cccaaaacgc aatttcacag aaaacaatca tccatgcgat accgttcaat 1582621 ccattcccct cttttcaata cagttgtatt atttaaataa tatgttacca tctttgtttt 1582681 tgtaacacaa ctgtattata aaaattgccc cgcctttgaa cgaaagctca aaggcgctac 1582741 gctgtattat tttgatgaaa gtggctgtca gctgtgctgg atatcaattg tatatactgc 1582801 acgatctgtt acgaccttca atccttcgtt ttcttggtga atatgaagct cacctaataa 1582861 aggaatctca taggcatttt gcggaagcgg tacgtttccg tcctcagtga atgttgttcc 1582921 ttcgccttct aaaacaagct cttctttcgc aacataatca tcaggatgat tcgtactgcg 1582981 tatagccact ttttgaaggt ggagaacaat ctgatccaag tctgatatct cttcatcatg 1583041 ggtcaattca ccttttctaa tatcaagcgt ctggccgact tttgattcca gccattgaga 1583101 aagctgtgta ttcgtgtgtg ccatcaatat tcctcctttt gatctacacg atactattcc 1583161 caattgctgc atcttttaca cgggaaagag ccgccccact ctttatgtat gaaacagttc 1583221 gctgttgagt gccttgatat agcgtacggc agaacgctgg accgattcgt cggcattttc 1583281 tttgacaact ttagagaaag cattgtaaag ccggttgaat tgaagcggtt ttactttggc 1583341 tgctatttct tcaactttgg aggcgggaag gggaatgaga tttgggtagc tgtacataaa 1583401 gctgacccag tttcgatccg ccgcaaccgt aatgatatct ccggtcaata gacagccttt 1583461 cccttcattg cccttgctcc aatgcaaaac agcaccgcct ttaaaatgtc cgcccagtcg 1583521 gtaaaggtcc agtcccggct tcatattgag cgtttcccct gaccagaagt gaatgtgatt 1583581 gcttggcctt gtcacccatt ctttatcatc ctcatggata tagatcggcg cctgaaacgc 1583641 ttcagcccac tcaacctgag tagagtaata atgtggatga gacaaggcga tggcttgaat 1583701 accgcctaat tcgttgattt ggtcaattgt cttttggtca agatatgtca tgcaatccca 1583761 cagcacattg aagcccttat gctgaataag atgggctgtt tgtccaatcg caaactctgg 1583821 ttcagttttg atgctgtaaa gatgctcttc ttccttttta aggatgtttt gaaggtttcc 1583881 tttctcacgc atgtcttcaa gggttgtcca agtttgtcca tcgggatgaa tatactgtct 1583941 ttcatcctcg caaatcagac acgagttggg cggatctaca gtctgtgcat gttgcacacc 1584001 gcatgtattg cagatataat atggcacttt cttcacttcc ttcatctatt ttccattatt 1584061 ttaccttatg attatgaata ttcaaacgaa aaaaccggca gttctgctga gagagaattg 1584121 ccggcttttg atgatgttta ttggccggga acggaatttt ctgcgttgac agcgcccgct 1584181 ccgtagatat tcggatcttc atctttccat ttgtccgtgc cgtttttcaa aagctctttt 1584241 acttcatcag gggtaagatc cgggttttgc tgaagaatta aagctgcgat tcctgcgcaa 1584301 atcggtgttg ccatcgaggt tcctgacatt gtaaagtact gagaccctac acggcttgac 1584361 ttttggagct tatcaatata agaattcgga gagcgaaggg aaataatatt aacacccggc 1584421 gctaaaatat cgggcttttc tttcccgtat actgtcgggc cgcggcttga gaaggaagcg 1584481 acagtatcat catcgctgct tgcagtattg ttatcgtcaa gcgcacctac tgtaatcacc 1584541 ttttcgctca cgcccgggct tgcaatggtc tgcgaatcag ggcctgagtt tccggcagcg 1584601 acacagacga caatccctgc gctccacgct tcctcaaccg ctctgactaa cggatcttcc 1584661 tgttcatgat catatctaag ggcatcgccc ccgagcgaca tgctcataat atcaatcggt 1584721 tcatcggggt tgtcctcatt gtattgaata caccactcaa caccctctat aatatctgct 1584781 aacgttcctg aaccctgctt gtttaatacc tttacgccga tgagattggc ttccggtgca 1584841 ggtccgcggt attgaccgga agaggatgca ccgctgcttg cgacatcacc tgcacagtgt 1584901 gtgccatgac cattatcatc gtacggctct gttttttgat tgaccatgtc cgcgaatccg 1584961 ataattcttc cttctagatc aggatgcggg tagattcctg tatcgacaac agcgacagta 1585021 acaccttttc ctgtcagggt ttgcccgttt ctgacgactt ccttcgcatg gcttgcttcg 1585081 gttgccgtgt ctaaaagcgc tttgacttcg cggtttaaat acactttacg gatattgctg 1585141 cattcagaga gaagggaatg taatgctgaa ggagtaacct cggcgctgca gcagttgatt 1585201 ttgttgaagc ggctttttag cttgctgcgt ttttcttttt gcagcacctc tccagccatt 1585261 tgaaagccgg tctcgtgaca gccttcctca aattcgataa tgactgacat tttttttctg 1585321 ttttgcaatt tggtttcgaa aaatttatgc aagaagcaag gagtccattt gaagggcttg 1585381 taaagttgca atacggtttc ccgtaacggc caatctagct tgtgagcatt tgctctcacc 1585441 atttgtacca tagagtaccc aaacatgtat tttcctccta ttataaggtt ctctgtatac 1585501 tctatgaaca gatgataggt ttggtaagtt tgtttgtcct ctgtaagaga cagacaagag 1585561 tttgtttttc tgaatctttc gcattagata cgatagattc agaagctgag gaaatcattg 1585621 gggattgaaa aagaacgttt gttcgtatta taatgtgatc atatcaaact gggaagggga 1585681 gagcaaccgt atgaatttct acttgcaccg atctttggaa agccaaatgc caatcagcat 1585741 tatatatgaa gaaagacgga acgattagta aaagaacgat tattgtgaga cagaaaagca 1585801 aaacgaaaat caaagcattt tgtttttcga aacaacagat cagaacattt ttattggact 1585861 ctatcctctc ctgtgatttt gtgagaacaa ataagcaaaa tctctattct gcaggccggt 1585921 aacagctgtc cgtctcagca accgggcagc ctgttactaa aaccctcctt aaacctatat 1585981 acatttattt gccaagtgag gttgttccta ccttttttgt ctttcctctc aacctttttt 1586041 cactcttatt tgaaatgaac cgctaataac cgtgacaatc aattgatttt ttgaaaccgg 1586101 gaactttttc actgatgata ttgtgtatac aatggtaaga taaaacctat tggctaaacc 1586161 tcatataatg aaccgcgcca ttcttatgaa aggagttaaa catgagaaga tttttactaa 1586221 atgtcatatt agtcttagcc attgtcttgt tcttgagata tgttcattac tcattggaac 1586281 cagaaccatc aaatcagcca gatacatatt caaatttcag cagcttggca gagaatgaga 1586341 gcccagccga ttacgatatt tcatataatg agaaaaaagg aagcaaagtc ttaattatgt 1586401 ctccgcatgg cggaagaatt gaaggcggag taagtgagct tgtgcgttat ttcaataatg 1586461 aatactctac atacctattt gaagggttga agtcccatga taaccaaaca ctgcacatta 1586521 caagcaccaa ctttgatgag ccattggcaa aaaagaaaat caaggagcat caatatgtgg 1586581 tggcttttca cggatataaa ggagagaaca agaataccct tgtaggggga acagaccgaa 1586641 agcgggcgaa aatgattgtg agagcccttg agcggagagg gttttccgct gagttagcgt 1586701 cgtctaaaag cggtcttgct ggattgaatg ccgaaaacat taataaccaa ggggaaacgg 1586761 ggctaagtat ccagctggaa atcagccgtg agcagagaga agcatttttt gatgattttt 1586821 attataaaaa tagaaaatac acaaagaaca gtgaatttta tgcttatgtc agtgcgatca 1586881 aaggtgtcct ggaaaaagag tattcgtaac aagcagatca gaagacaaaa taagagaaga 1586941 tcagtagact gaaataggat aaaaaaggag gcaaaacaat ggcagatcat catttttatt 1587001 taaaagcgaa ctggccgggt aaccgtaatg atgtcggtac gatcgaaagc ggaaacctga 1587061 tcacatcgat ttccattcct aaagaaatgg atggcccggg agaagggacc aacccagatg 1587121 aaatgcttct cggggcggca gcgacctgtt acattattac acttgcagcg atgatggaga 1587181 gaagcgggct ggaaaaagaa gacttacaga tggagtcaga aggcattgtc aacgttacaa 1587241 aaggagtctt tacatacaaa aagatcattc accgtccctc tgtcgtgctt aaacatgatg 1587301 cttcacaaga cgacgtcgca ttggcgcaca aactttgtaa aaaagcggag tcgtcatgca 1587361 tgatttcgcg tgcaattcaa ggaaatgtcg agctgcagct tgaagcctct gtgaaactgg 1587421 gtggagaata aagaaaacag acggtcactc acaggccgtc tgttttttat cttcagcgtg 1587481 ggctttcgat tgatttagca cgaccacgcc tgcaatgaca agcgtgagac cgaatacacc 1587541 ttttaaactg atggtttcgc caaaaagcaa aaacccgaca attgctgtaa gcgcggtacc 1587601 aacgcccgac catgttgcat acgcgcttga taagtcaatt gtttttaaag aaaagcttag 1587661 aaacgtaaaa gcagaaagaa atccgactat gactccggca atgggccagg cttgtgtaaa 1587721 tccttctgaa agcttcaaca tcgtgctccc aaacacttca gatacaatgg cgagagccaa 1587781 ataaagcaat cctctcatct tcatcactcc tttacggcca attaagtaac acgacccctg 1587841 atagtaataa aagaatcccg ataagccctt tggcattcag atcttccttg aaccatttta 1587901 ctccgatcac tgtcgtcagc accgtgcctg ccccgctcca agtcgcatag gagaggctca 1587961 ggggaatatg gtttaaagtc agggacagca tataaaaggc gagggaatag ccaataacga 1588021 ccaaagcact tggcttccac tttttgaagc catcagatac tttcagcatg gctgctccta 1588081 tcgattccga acatatggca atcgtgagga atatatatcc tatcaacatc atgaattctc 1588141 ctcactatat ttttagatta gaaaaaaaac ttcagctaga aaaatattag tgtatgccta 1588201 tgtatgagtc aagagattca ttttcacaca cttaaaaaga ccccttttta aggggtcttt 1588261 tgcgtttaat aataaaaagg gaacggggca tacggataat aggggtatcc gccatacaaa 1588321 taaggattaa ataaagcgct tcctataagc ccgcctgcaa ggccgccgat aaacggtcct 1588381 ccaaaaaatc cgaatggccg gccaaaccca taaccaaatc cgggtcttcc aaacccgtaa 1588441 ccgaacccga acggtcttcc aaacccaaat ggtctcccga atccgaacgg ccttccaaat 1588501 attcttgtat cttcagggct gaaatgctct aactcgttca tgttttcttt cctcctgtaa 1588561 taaagtgtag atgatgcagt gtattcaccc tgcccggatt tgattgggcg aatcgaggaa 1588621 aaggaggatg tgaacacatt gggcctgtat cagtctgact ggtcaaaagc accgccccac 1588681 gcacatgctt atcatgtcaa aacaacgaga gaacagggcc attatcatct catcgaaggg 1588741 tttactcagc cggcaaacgg atcaaatacc gatcagcata cacattacta tacagggatc 1588801 acttcatttg aaaacggcca ttttcatcgg tattacggaa tctcaggacc ggcgattccc 1588861 ttagcagatg gcacacatta tcatgaaatc gaagaaacga cgtatctggc ctataacgag 1588921 ccgattgaga tccagtacgg aggggttgtg tacgatcccg gagatgacag aagaaaaacg 1588981 catcgtcata ccctgaaagg aaagacaagg gaaattgtcg gcaatgagcc gctcggctgg 1589041 tagaaggatg tttaccgatg caaaaaaagg gcaaaatgga taggtggttg tccatgttga 1589101 atgctataat ggggggagat ttataaaaga gagtgataca tattgaataa tacgaagcag 1589161 cccgttgtca ttttagtcgg accgacggca gtggggaaaa ccaatttaag tattcagcta 1589221 gccaaatcct taaacgcgga aattatcagc ggagattcga tgcagattta taaagggatg 1589281 gatattggaa cagctaaaat taccgaacag gagatggagg gagtgcccca tcatctgatt 1589341 gacattttag atccccaaga ctctttctct actgccgatt atcaaagctt agtaagaaat 1589401 aaaatcagcg agattgcaaa tagaggaaag cttccgatga ttgtcggcgg tacagggctt 1589461 tatatacaat ctgtgcttta cgattataca tttacggaag aggcaaatga tcccgtgttt 1589521 cgagagagca tgcaaatggc tgctgagcgg gaaggcgctg actttcttca tgccaaactt 1589581 gctgcagcag atcccgaggc agcagctgcg attcatccga ataatacaag aagagtcatt 1589641 cgcgcactgg aaattttaca tacgtccgga aaaacgatgt cccagcattt gaaggaacaa 1589701 aaacgagaac ttctgtacaa tgcagtgtta attggcctga caatggatag agacacgctt 1589761 tacgaaagaa ttaatcagcg ggtcgatttg atgatgcagt caggccttct tccggaagtg 1589821 aaacgcttat acgacaagaa cgtgagagac tgtcaatcaa tacaggcgat aggctataaa 1589881 gagctgtatg catattttga cggttttgtg acactttccg atgctgtcga acagctaaag 1589941 cagaactcga ggcggtatgc gaaacgccag ctgacgtggt ttcgcaacaa aatgcaggtc 1590001 acatggttcg atatgacacc gcctgttgat atggagctga aaaaaaagga aattttcaca 1590061 catatagcag gaaaactcga actttaatcg aaactgtatg atatagagaa tcaaggagga 1590121 cgaaacatga aaccgattaa tattcaggat cagtttttga atcaaatccg gaaagaaaat 1590181 acgtatgtca ctgttttttt gctgaacggc tttcagttgc ggggccaggt gaaaggcttt 1590241 gataacttta ccgtattgtt ggaatcggaa ggtaagcagc agcttatata taaacatgcg 1590301 atctcaacgt ttgcgccgca aaaaaacgtc cagcttgaac tcgaatagat caaaaaatgc 1590361 catgtcaaga catgaggaaa ggctgtcggg ggttcccggc ggccattttt aacatgaatc 1590421 cacttttgct ccaagctttt tgtgtaagct gaccatgcca aggcacggtc tttttttatg 1590481 agaacaacat acggaagtaa aaatggtata ttatgtataa aatgaatttg ggagtgatcg 1590541 atcttgtttg aaagtgaagc agaactgaga cgaatcagga ttgcacttgt atggatagct 1590601 gtctttttac tgttcggggc gtgcgggaat caagatacca ttattgaaac agacaacggc 1590661 aattcagact atgaaacgcc tcagcccacc tcgtttccac ttgaacataa ccattttggc 1590721 gttatggagg acggctatat caaaatttat gagtataatg agtcccgcaa tgaggtaaag 1590781 ctgaagaaag aatacgcgga tgatgagctt gaataaaatt cacaagcatt cgaatttaca 1590841 aagcggatgc cagccgctaa actaaataca gacacagatc aaacagaggg tgaaaacatg 1590901 aagcataaag tgatcgtgaa tcattgggaa gaaatttgcg aagatgattc ttgctatgaa 1590961 tacggaacaa gtatcattgt gaacggaaaa gaattaatca gagaagcgtc aattatcact 1591021 gctttgaagg cggttttaga agagatcggc gcggatgttg aaatagaaga aacagtagag 1591081 agcgaaaaat gctgtgatag cttaagaaaa aaaaatctag actactaagc agtttttttt 1591141 catgttatga tatacatcgg ctaaaaacga caccccgagt aggacgagag atgattctcg 1591201 ttctgctctc ttttttgggc cctaatgagt ctgcccgttt gcctgatttg atcaaaatat 1591261 gaatttttca taaaaacgaa tctatatatt gtgtttttgc tagagggtag tatactatat 1591321 atagtgttag tgatgagaga ttcatatttt ttgataggtc gtgataaaac gtggtacaaa 1591381 tcatatttga ttcgaaaaca gggaatgttc agcggtttgt gaataaaaca ggctttcagc 1591441 agatacgcaa ggtggacgaa atggaccacg tggacactcc gtttgttttg gtcacctaca 1591501 cgacaaactt cggccaggta ccggcatcaa cacaatcatt tctcgaaaaa tacgcccatc 1591561 tcttattggg agtcgctgcg agcggcaaca aagtatgggg cgataacttt gcaaaaagcg 1591621 ccgataccat ttcaagacaa tatcaggtgc cgatcttgca caaatttgaa ctcagcggca 1591681 catctaaaga cgttgaattg tttactcagg aggtagaaag agttgtcaca aaatcaagtg 1591741 ccaaaatgga tccagttaaa taacgaaatc atgatccaaa aagatgggaa attccagttt 1591801 gataaggata aagaagctgt acatagctat tttgtagatt atatcaatca aaacacagtc 1591861 ttctttcaca atttaaaaga gaagctggat tatttggttg aaaaccaata ctacgaagag 1591921 gaattcttaa gcctttattc ttttgaagac attaaagaag tgtttaagac agcttacgct 1591981 aagaagtttc gttttccttc cttcatgagt gcgtttaaat tctataatga ctatgctttg 1592041 aaaacgaatg acaagaaaaa aatcctcgag cgttatgagg accggatctc aattgttgcg 1592101 ctgttcttcg ctaacggcga cactgagaaa gcaaaagaat atgtaaacct gatgatcaat 1592161 caagaatatc agccgagcac accgacattt ttgaatgccg gcagaaaacg ccgcggtgaa 1592221 cttgtgagct gcttcttgct cgaagttaat gattctttaa atgacatttc aagagcaatc 1592281 gatatctcca tgcagctttc taagcttggt ggcggggttt ctcttaacct gtccaagctt 1592341 cgcgcgaaag gtgaagccat taaagatgtt gagaatgcga caaaaggcgt tgtaggcgtc 1592401 atgaagcttc ttgataacgc gttccgttac gctgaccaaa tgggacaaag acaaggctcc 1592461 ggcgcggcgt atttaaacat tttccaccgc gatatcaatg attttcttga tacgaaaaag 1592521 atttctgcgg atgaagatgt gcgtgtcaaa acgctttcga tcggtgttgt cattccggat 1592581 aagttcgttg agcttgcacg cgaggacaaa gcggcttatg tattctaccc gcacacgatt 1592641 tataaagagt acggccagca catggatgag atggacatga acgaaatgta cgacaagttt 1592701 gtcgacaacc ctcgggtgaa aaaggaaaaa atcaacccgc ggaaactgct tgaaaaattg 1592761 gcgatgcttc gttctgaatc aggctatcca tacatcatgt tccaagataa cgtcaataaa 1592821 gtgcatgcga ataaccatat ttccaaggtc aaattttcta acctttgctc tgaagtgctg 1592881 caggcatctc aagtttcttc atacacagac tatgatgaag aagatgaaat cggtctggat 1592941 atttcctgca acctgggttc gcttaacatt ctcaatgtca tggagcataa atcaatcgaa 1593001 aagacagtca agcttgcgac agactcttta acacacgtgt ctgaaacaac agacatccgt 1593061 aatgcgcctg ctgtaagacg ggcaaacaaa gcgatgaaat caatcggcct cggtgctatg 1593121 aaccttcacg gctaccttgc gcaaaacggc attgcgtatg aaagtccgga agcgcgtgac 1593181 tttgcaaaca cgttctttat gatggtgaat ttctactcca tccagcgttc tgcggaaatc 1593241 gcaaaagaga agggcgaaac gtttgatcaa tatgaaggat caacctatgc gacaggtgaa 1593301 tacttcgaca aatacgtttc aactgatttc tcaccgaaat acgaaaaaat cgctaatctg 1593361 tttgaaggta tgcatatccc gacgacagag gactggaaaa agctaaaagc atttgtcgct 1593421 gaacacggta tgtatcacag ctacagatta tgcattgcgc cgacaggctc tatctcatac 1593481 gttcaatcaa gcacggcgtc tgttatgccg attatggaac ggattgaaga acgaacatac 1593541 ggcaactcaa aaacgtacta cccaatgcct gggcttgcat ctaataactg gttcttctat 1593601 aaagaagcct acgatatgga catgttcaag gttgtggata tgatcgccac tatccagcag 1593661 cacattgatc agggaatcag ctttacattg ttcttaaaag acacaatgac gacccgagat 1593721 ttaaaccgaa tcgatctgta tgcacatcat agaggaatta aaaccattta ctatgcaaga 1593781 acgaaagata ctgggcaaga cagctgcctt tcttgtgttg tttgattaaa ggagagttta 1593841 tagtgacaaa aatttatgac gcagcaaact ggtcaaagca tgaagacgat tttacccaaa 1593901 tgttctataa ccaaaacgtg aaacagttct ggcttccgga agagattgct ttaaacggcg 1593961 atctcctcac atggaagtac ctcggaaaaa atgagcagga cacttatatg aaggtactgg 1594021 ccggacttac gcttcttgac acagagcagg ggaatacggg gatgccgatc gtggctgaac 1594081 acgtagatgg ccaccagcgg aaagcggtgc tgaactttat ggcgatgatg gagaacgctg 1594141 tccatgcgaa gtcgtactct aatattttca tgacccttgc accgactgaa acgatcaatg 1594201 aagtatttga atgggttaaa caaaataaat atttgcagaa aaaagcgcaa atgattgtcg 1594261 ggctttacaa agccattcaa aaagatgatg aaatttcact gttcaaagcc atggttgctt 1594321 ccgtctatct ggaaagcttc cttttctaca gcggtttcta ttatccgtta tatttctacg 1594381 gacaaggaaa actgatgcaa agcggtgaga tcattaacct gatccttcgt gacgaagcga 1594441 ttcacggcgt gtatgtcggt ctccttgctc aggaaattta taataaacag acagaagaga 1594501 aaaaagcaga gcttcgtgaa tttgcgatcg acctcctgaa tcagttatat gaaaatgagc 1594561 ttgagtatac agaggacttg tacgatcaag tcgggctctc acatgatgta aagaaattca 1594621 tccgctataa tgcgaataaa gcgctgatga accttggatt tgatccatac ttcgaagagg 1594681 aagacattaa tccgatcgtt ttaaacggat taaacacaaa aacaaaatcg catgacttct 1594741 tctctatgaa ggggaatggc tataaaaaag cgacagttga gccgctcaaa gatgatgact 1594801 tttattttga agatgaaaaa gagcagatat aatatctgct cttttcggct tgaaggttca 1594861 aatgaggagg acgcagtacc catgggaaaa atggacgaaa tgattttagt tgccccgcgc 1594921 gatgatgtgt ttaaaaaaga aagcttaacc ttccagggcg tgtacagtga agatagcaga 1594981 gtagcagaaa tcatggctca gattgaagcg gcctatcgtg aaatgagaag aggggacgca 1595041 gaagaagatc cgcgtttcaa gcagccgata ccttatgtcg tcattaagcg tgaagatgaa 1595101 gtttttcttt acgagcggct ggctggcggc ggtgaatcac gtctgcacaa caagctttct 1595161 ctcggttttg gcggccatat gaacgccatc gaaggggcag cttcatttgc tgaagtctta 1595221 aagctgaaca cagaccgtga gcttgaggaa gaactgcaaa taaatgaaga agataaacag 1595281 gcgattgtca cactgggatt gatcaatgat gatgaaaaca gtgttggcaa agtgcatatc 1595341 ggtattcttt ctgcgcttca attaaagcct ggcgcacaag tggaagtgaa ggagaaagaa 1595401 caaattgcgg gtaaatggat gaaagtttct gaattaaaac aggatgatat ctacaaccgt 1595461 ctggaaacat ggtcacagtt tgttgttgat attcttgaat aaaaaaaccc ggtttctcgc 1595521 gatgaggagc cgggtttttt tatgagacgc tcgtccccgt ctcggctatg attctaggat 1595581 cacaatagcg tcaaagccgg catttttcgc tctggcagcg agggtgtctg cattgtcttt 1595641 ggatgaaaat gcgccaatct gcactttgta taatccgtcc tttaaaagga caatcgagtc 1595701 aaaacctttg gcttcggcat tacttgcgag cgagtcggca ttcgctttga ctttaaatgc 1595761 gccgatttga accttatata accctgagct ggaagtcttt ttaaggttaa aggcttgctc 1595821 cagcccgttt gcatgtcctc tcgctaagct ttgaataaaa ctgctcgttt tcagcttatt 1595881 tgcatcggaa acggtatcaa tgaagccgtt ctcggtcaag agggcaggca ttgccgactc 1595941 ccttaggacg tggaagttcg ctgttttttt gccgcgatcg gcaaagtcga cagcttgtat 1596001 cacttcagag tgaattgtcg attgataagt cgtcgtcggg gctcctacat ctggataaat 1596061 atagctttca aaacctgtgc ctcccccgga attaacgtga atggacaaaa agaaatctgc 1596121 tccccagtta tttgcggcat ttgtccggtc gtttaagctg acatattggt cgcttgtccg 1596181 gctcagcagc agagaaacgc cttcatattc attagttaat atcgtacgta aggctaaagc 1596241 gatttgcagg gttaacgttt tctcctgaag gccattacct gttgcgcctg gatcagaccc 1596301 gccatggcca ggatcaataa aaattttaac catttttcat cacctcatta caggatatga 1596361 aaaaacacgg cttctgcttg tacgattatc attcaactga aaaatgagga aataaccctt 1596421 tcacatccag aaattatttc tcgggaaagc gcacaattca acatgaagcg acaacagata 1596481 cggtccgaca tgaaatctgt gcatacgcca tatgtttgta tgtactatgg gttcggttaa 1596541 cctgcactga ttcctgctgg ttttaagctt tgcgttcata ttaaatcaag catttaaaac 1596601 gtaaattgat gaggaaagct cctttcatta aagacaccgc tttataaatc gaaaaaaaga 1596661 aaaacacttc aggtatctta gggcgggtaa tacgtttcgt acaaaaatca gcccgttgta 1596721 tgaaaaagaa ataatgagaa agaagctcac tataatactc tgacaaaatg attaaaaaca 1596781 aaatctcatg gtttgtccac cccatgtccg tgaatacaat aagaaataaa gtatttctcg 1596841 ggaaagcgca ggattcctta ttgttcccga aaaaagcaat tgtttcgaca catgataggc 1596901 gtttgtcaca atcggcatcc gcttgaatat catatagaga gaacagagag gtgaagatgt 1596961 tggagcgcgc tgtgacttat aaaaacaacg gacagatcaa cattattctg aacgggcaaa 1597021 agcaggtgct gacgaatgct gaggcagagg cggaatatca ggctgcattg caaaaaaacg 1597081 aagcaaagca cggcattttg aaggaaatcg aaaaagagat gagcgcatta gttgggatgg 1597141 aggaaatgaa acgcaacatc aaggaaatat acgcctggat ttttgtgaac caaaaacgcg 1597201 cggagcaagg cttgaaggtt ggaaagcaag cgctgcacat gatgtttaaa ggaaatccgg 1597261 gaacgggaaa aacgacggtt gcacggctca tcggcaagct gttctttgaa atgaatgtcc 1597321 tgtcaaaagg ccacttaata gaagcggagc gggctgacct ggtcggggag tatatcggac 1597381 acaccgccca aaagacgaga gatttaatca aaaagtcatt aggtggcatt ttgtttatag 1597441 acgaagccta ctcgctggca agaggcggcg aaaaggactt tgggaaagaa gcgatcgaca 1597501 cacttgtaaa gcatatggaa gacaaacagc atgagtttat tttgatactc gccggatatt 1597561 cacgggaaat ggatcatttt ctctcgttaa atcccggact ccaatcaaga tttcccatct 1597621 ccattgattt tccggattac tctgtgaccc agctcatgga gattgcgaaa cgaatgatcg 1597681 atgaaaggga ataccagctc agtcaagaag cggaatggaa attgaaagat tacttaatga 1597741 cagtgaaaag cacgacaagt cccattaaat tcagcaatgg acgttttgtc agaaatgtga 1597801 tcgaaaaatc gatcagagca caagccatga ggcttttaat gggagaccaa tacttaaaaa 1597861 gcgacttgat gaccatcaaa agccaagatc tttccattaa agaagaagca tctggatctg 1597921 catagacctc tcagtttttg agaggtctgt tttttgctcg tatttccgct tttcaaagca 1597981 atcgatttgt ggtatacaca tgcagggttt ggtatgataa tactactgcc caatatgcaa 1598041 aagaaaggaa catccatttg aacgaacaag aaacgattca ggagaaagcc attttagtcg 1598101 gatgtcagct gccgcatatc acggatgagc attttgaaaa ttctatggaa gagctagcat 1598161 ctctgacgaa aacagcagac ggaaaagtac tgaccagcgt cacacaaaaa cggaacaggg 1598221 ctgacgccgc tacatatata ggaaaaggga aggtagaaga gctgaaggca ctcgtggaag 1598281 agcttgaagc tgatctcctc atctttaatg atgaactgtc gccaagtcag ctgaagtcat 1598341 tggcaacagc aattgaagtg aagatgattg accgcacgca attgatatta gatatttttg 1598401 caaagcgggc gagaacgaga gaaggcaaac ttcaaattga gctggctcag ctgcaatatg 1598461 cactgccgcg tctgacggga caagggatca acctttcccg gcaaggcgga ggaattgggg 1598521 caagaggtcc cggggaaacg aaactggaaa ccgaccgccg ccatatcaga aatcgcattc 1598581 atgaaatcaa cacacagctt tccactgtca ttcgccatag aagccgatac cgtgaaagaa 1598641 gaaagaaaaa cggtgtgctt caaattgcgc ttgtcggcta tacaaacgca gggaaatcaa 1598701 catggttcaa ccgcctgacg agtgctgaca gctatgaaga agacctcctg tttgccacgc 1598761 tggacccgat gaccagaaaa atggtcctgc caagcggcta cagtgttctt ctttcagata 1598821 cagtaggatt tattcaggat cttccgacga cattgattgc tgcattccgc tcaacgcttg 1598881 aggaagtaaa agaagcggat ttaattctgc atttaattga ttcttcaaat gaggattatg 1598941 cgggacatga aaaaacagtg cttcggctgc ttgaggagct tgaagcagat gatatcccga 1599001 tgctgacggc ttacaataaa cgtgatcaaa aactgcctga ttttataccg accgccggaa 1599061 gggatcacat tatggtcagt gcgaaatttg aggacgacgc tgcagccttt aaagaagcga 1599121 ttcagcgcta tttgcgccaa gaactgttaa cgtcttttga agcacatgtg ccggcaagtg 1599181 aagggaagct cctttccaga atcaaatcgg aaacgatggt agaccgcttc tattttaatg 1599241 aagaaaatga acagtatgac atatccggct atgtccaaga agagcaaagt atcatcggtg 1599301 aattaaagaa gtatatgtag gaaggaaata taaagacatg tttgacacat taacacacgg 1599361 agaattattg aagaaaacgg caatggaagt ggaagcggac attgccggca ttcataaaca 1599421 aatagaagaa atcagcgagc gaaatgagtg gagagtgctt caaagctata gaaaacacaa 1599481 agtaagcgac actcatttca cgccgtctac tggatacggc tatgatgata tcggaagaga 1599541 cacgcttgaa agcatatatg cggatgtgtt tggcggagaa gcggggcttg taaggccgca 1599601 aatcatttca ggcacacatg ccatctcaat tgctttgttc ggtgtcctca gaccggggga 1599661 cgagctcctt tatatcacgg gcaagccgta tgatacgcta gaggaaattg tgggcgtcag 1599721 gggtggagaa aacgctggtt cgttaaagga ttttcaaatc ggctataatg cggttgatct 1599781 gacgaaagac ggaaagatag actatgatgc agtcgccgct gcgatcaatc cgaagacaaa 1599841 agtaatcggc attcagcgct caaaaggata tgcgaatcgc ccttctttct taattagtga 1599901 aataaaagaa atgatccgtt ttgtaaaaga aatcaatgaa aatctgatcg tctttgtgga 1599961 caactgttac ggagaatttg tggaagagct tgagccttgc catgtcggag ccgacctgat 1600021 ggcgggatct ctcattaaaa atcccggcgg cggccttgcg aaaacaggcg gctacctcgt 1600081 cggaaaagcg aaatggattg aagcttgctc ataccgtatg acgtcacccg gcatcggcag 1600141 agaagcgggg gcatctcttt actcgctcca agaaatgtac caaggcttct ttttggcgcc 1600201 tcacgttgtg tctcaaagtt taaagggagc ggtgtttaca gcgagattcc ttgaaaaact 1600261 cggcttcact tcaaacccga aatgggatgc gaaaagaacg gatttaatac aatccgttga 1600321 gttttctgac agagaaaaga tgattgcttt ttgccaggct attcaatttg catcgccaat 1600381 caatgctcat gtgacgcctt atccagccta catgcctgga tacgaggatg atgtcattat 1600441 ggcagcaggg acgtttattc aaggagcaag catcgaatta tcagctgatg gccctatccg 1600501 cccgccgtat gtagcgtatg ttcagggagg attaacctat tcgcatgtga agaatgccat 1600561 atgcagtgca gtggattcat tgatgcaaaa gcaattaatt taaatttttt aaaaatttct 1600621 ctggatttga tgttaagaat ccttacatcg tattgacaca taatataaca tcacctataa 1600681 tgaaactaag ttaagaaaag gaggaaattg agatgagtga taatattcgc cgctcaatgc 1600741 ctttatttcc aataggaatt gtcatgcagt taactgagtt atcagcaaga caaattcgat 1600801 attatgagga aaatggactg atatttccag ccagaagtga aggaaataga cgattatttt 1600861 catttcatga tgtagataaa ctgttagaaa tcaagcacct gatagaacaa ggtgtaaaca 1600921 tggcaggaat taaacagatt ctggcgaaag ccgaagccga gccagaacaa aaacaaaacg 1600981 agaagacgaa aaaaccaatg aaacatgatc tgtccgatga cgaactgaga cagctcctga 1601041 aaaacgagct catgcaagcc ggccgttttc aaagagggaa tacattccgt caaggcgaca 1601101 tgtcccgctt ctttcattaa tccgttagca actgttttgc tatatacatt taccttttaa 1601161 gaggaggaat tttaccaaat ggcaaagtac actagagaag atatcgaaaa attagtaaaa 1601221 gaagaaaacg tgaagtatat ccgccttcaa tttactgaca ttcttggaac aatcaagaat 1601281 gttgagattc ctgtaagcca gcttggaaaa gcgcttgata ataaagtcat gtttgacggt 1601341 tcttctattg agggattcgt tcgtatcgaa gagtcagaca tgtacctgta tccagatcta 1601401 aatacatttg ttatcttccc atggacagct gaaaaaggta aagtagcacg tttcatctgt 1601461 gatatttaca atccggatgg cacacctttt gaaggtgacc cgcgaaacaa cttaaaacgg 1601521 attctgaaag aaatggaaga cctcggcttc agtgatttta accttgggcc tgagcctgaa 1601581 ttcttcttat tcaaattgga cgaaaaaggc gagccgacgc ttgaactaaa cgacaaaggc 1601641 ggatatttcg acttagctcc aactgattta ggagaaaact gccgccgcga tatcgtactt 1601701 gagcttgaag agatgggctt tgaaatcgaa gcgtctcacc acgaagtagc acctggtcag 1601761 cacgaaatcg actttaaata tgctggagca gtccgctctt gtgatgacat ccaaacattt 1601821 aaactagttg tcaaaacaat tgcccgtaaa cacggcctgc atgcgacatt tatgccaaaa 1601881 ccattgttcg gtgtaaacgg ttcaggtatg cactgcaatc tatcactctt caaaaatggt 1601941 gttaacgcat tctttgacga aaacgcagat cttcagttaa gtgaaacagc gaagcacttc 1602001 attgcaggta tcgtgaagca cgcaacaagc tttacagcag taacaaaccc gacagtaaac 1602061 tcttacaaac gtcttgttcc tggctatgaa gcaccttgtt atgtagcatg gagcgcgcaa 1602121 aacagaagcc cgcttatccg tatcccggct tctcgcggca tcagcacacg tgttgaagta 1602181 cgcagtgtag acccagctgc aaacccatac cttgcactta gcgtattgct tgctgcagga 1602241 ttagacggaa tcaaaaacaa actggaagcg ccggctccaa tcgaccgcaa catctatgtg 1602301 atgagcaaag aagagcgcat ggaaaacgga atcgttgacc ttccagcaac acttgcggaa 1602361 gcactagaag aattcaaatc aaacgaagtc atggtcaaag cgctgggcga gcacctattc 1602421 gaacacttca tcgaagcaaa agaaatcgaa tgggatatgt tccgcacgca agtacatcct 1602481 tgggaacgcg aacagtatat gtctcagtat taatatctca atcccttggc actaaaagtg 1602541 tcaggggatt ttttatgtta ataggtaata aattatggag cggcatagtg tttaacacag 1602601 ccattaatcc tcagacagtc aaatagccat ttctactccg gttgaaagct tctctatttt 1602661 tgcttcttat ttatctttcc tgtattgata tatgtatgta gggttggact tataacataa 1602721 actattctgg ccattccgtt ctttcaattc atgaccgggc ttgccatcag cataaatcta 1602781 ggctaacagt ctccatacat cctgtgatca cctttatcaa actcttaaat gcaacttacc 1602841 actaaccaat tctttatttc gcatagatca tctttgtcat gtgtttacac aagaatctgt 1602901 tttggactga gacactgaat ataacaaaac agtcaaaaat caatatttaa ttcattctgt 1602961 ttaaactttc tgaaaaagat gttgaaaaag tcgaaaggat tttataatat taagtcaagt 1603021 tagtttgttt gatcaacaaa ctaatgaaat gaactttcat tatccacaag ataagatctt 1603081 actaatatgg atggaagggg gataagaggg tcgatttaat ggagctaaac aatataagaa 1603141 acgaaagaat gaggctttta tccttttcca ggtatataag gtatgacgaa aaaagatgaa 1603201 ttttttgctt gctgatcacc atattttttt gcactgtttt gaaagcgctt ttataaaagt 1603261 ttactgaccg taaattcgag aaattgttat accgtttcac actgttccat attaaaggat 1603321 cgaaaagggg agaaatcatg ctcagtgaaa atgtaaagaa gattagcatg gttgaaaaag 1603381 ttggatatgc gtctggagat tttgcttgta atttaattta tgcaacagtg tctacgtatc 1603441 ttttgttctt ctatacagat gtttttggtt tatcggcagc agcagccggt actatgtttt 1603501 tagtggttag aataatcgac gctctcgctg atccttttat cggaacaata gttgacagaa 1603561 cgaacagcag atttggacgc tttagaccgt atcttttatt cggagctttt ccatttgtca 1603621 tactggcaat actctgtttt acaacaccag acttttcgga tatggggaaa ttaatatatg 1603681 cctatataac ctatgttggc ttgtcgctta catacacaac gataaacgtt ccatatggcg 1603741 cgttaacttc tgcaatgact agaaataatc aagaagttgt tagtataact tctgttcgca 1603801 tgttatttgc gaatcttggg ggacttgtcg ttgcattttt tgttccctta ctggctgctt 1603861 atttaagcga tacttccggc aacgagtctc ttggctggca actaaccatg ggtattttgg 1603921 gaatgatagg cgggtgcctt ttaatctttt gttttaaaag cacaaaagag cgggtcactc 1603981 ttcaaaaatc cgaagagaaa attaaattta cggatatatt tgagcagttt cgtgttaatc 1604041 gtccacttgt tgtattaagt attttcttta ttattatttt tggagtgaat tccatcagta 1604101 attcggttgg catttactac gtaacgtata acttagaaag agaggatttg gtgaagtggt 1604161 acggtttgat aggaagttta cccgctttgg tcattttacc gtttattcca aggcttcatc 1604221 aatttttggg gaaaaagaaa ttactaaact atgcattatt actgaatatt ataggcctct 1604281 tagctttact gtttgttccg ccaagtaatg tttacctcat acttgtctgt cgattaatcg 1604341 ctgctgctgg aagtctcact gccgggggat atatgtgggc gcttattcct gaaacaattg 1604401 aatatggaga gtacaggact gggaaaagaa tgggtgggct catttacgct ataatcggat 1604461 ttttctttaa gtttggtatg gccttaggag gagttgttcc gggtctggtt cttgataagt 1604521 ttggatatgt agcaaatcag gcacaaaccc cggcggcctt aatggggatt ttaattacaa 1604581 caaccattat tcccgtgttc ttgcttgttc tagctttaat tgatattaat ttctataact 1604641 tagatgagaa aaaatataaa aacatggttc gagaattaga gaatagagac aaagtttatt 1604701 tggatcatat tgatgatttc aaggcttaaa aaagaaaata aactgaggag gagtcccaaa 1604761 tgaagattac caatcccgta cttaaaggat tcaatcccga tccaagtatt tgtagagcag 1604821 gagaggatta ttatatcgct gtatctacat ttgagtggtt tccgggagtc cagatacacc 1604881 actcaaaaga tttagtaaat tggcacttag ttgcacatcc attacagaga gtttcacaat 1604941 tagacatgaa aggaaaccca aattcaggtg gagtttgggc accatgttta agctatagtg 1605001 atgggaagtt ttggctgatc tatacggatg ttaaggtagt agatggcgca tggaaagatt 1605061 gtcacaatta tttagttact tgtgaaacga ttaatggtga ttggagtgag ccgattaaat 1605121 taaatagctc ggggtttgat gcttctttgt tccatgatac ggatggaaaa aagtatttat 1605181 taaatatgtt atgggatcac cgtattgatc ggcactcatt tggaggaatt gttatacagg 1605241 aatattctga taaagagcaa aaattaatcg gtaaaccaaa agttatattt gaaggaactg 1605301 atagaaaact gacagaagct ccgcatcttt atcatatcgg gaactattat tatttattaa 1605361 ctgcagaagg aggaacacgg tacgaacatg ctgctacaat tgctcgttct gcaaatattg 1605421 aggggccata tgaagttcat cccgataatc caattttaac gtcatggcat gacccaggaa 1605481 atccattgca aaaatgtggt catgcatcca ttgttcaaac acatacagat gagtggtatt 1605541 tagctcattt aacgggacgt cctattcatc ctgacgatga ttcaattttt cagcagagag 1605601 gatactgtcc tttgggcaga gaaacagcta ttcaaaaact ttactggaaa gatgaatggc 1605661 cctatgtagt aggtggaaaa gaaggaagct tggaggtaga tgcaccttct atacccgaaa 1605721 caatatttga agcaacgtac ccggaagttg atgaatttga ggattcaaca ttaaatataa 1605781 attttcaaac tttaaggatt ccattcacga atgaattagg ttcattgact caagcgccaa 1605841 atcatttacg attattcggt catgaatcat tgacctcgac atttactcag gcatttgtag 1605901 ccagacgctg gcaaagtctc cattttgaag ccgaaactgc tgttgagttt tatccggaaa 1605961 attttcaaca agccgctggg ttggtgaatt actacaatac agagaactgg acggctcttc 1606021 aagtcacgca tgatgaagaa cttgggcgca ttcttgaatt aacaatatgt gacaactttt 1606081 ctttttcaca gccattaaat aataaaattg ttattcctcg tgaagtaaag tatgtatatt 1606141 taagagtaaa tattgaaaag gacaaatatt attatttcta ttcttttaac aaagaagatt 1606201 ggcacaaaat tgacattgca ctggaatcga aaaaattatc agatgattat atccgtgggg 1606261 gaggattctt cacaggggcc tttgtaggga tgcaatgcca agataccagt ggtaatcata 1606321 ttccggccga ctttagatat tttcgttata aagaaaaata atttgcacat gaaaaaggag 1606381 atttctattt tagaactcct ttttcatatg agaaggtgcc atgtcactat tgcttcagaa 1606441 atactcctag aataaaaaaa ctcatcttta aagatgagct gtccattcca taaaaaatta 1606501 cattgtaatc atgtccagaa aatgatcaat cacaatggag gacattccta atgccggtgc 1606561 attctgtcct aaggaagatg gcaataattc atagctattg cctaattggg aataaaccct 1606621 tgatgatact tcacttctca ttgaatttaa aaccatagga tgcgattcaa ttatgctatt 1606681 tcttaaaatt acggcttgtg ggttgaaagt atttagaata ttggtaaggc ctattcctaa 1606741 atagaatcca aaattttgta atgcatttaa ggttccgata tcattcagat gggcgaggtt 1606801 tatgatatct tgataggaca gttttttctc tttggtctga agagatttta ataaagcctt 1606861 ctctgaagca tacaattccc agcatcctcg gtttccgcaa ctgcatttag gaccattaaa 1606921 gtctattgtc atatgtccca tttctccaga gaagccgctt actcctctat ataaatgatt 1606981 gttgataata acaccgatcc ctattcctgt gctgatactt acgtaaataa tgttatcgtg 1607041 attttttgca gctccaaata ctttttctcc atatgcgcca gcatttgcct cattttcaat 1607101 aaaaacaggc acattgtact tctcttgtat cgaagatttt aagtcaatat ctctccagtt 1607161 ggagttcgga gtgaaaacaa ttttttgatc tttatcaatg agtccaggca cgcaaatacc 1607221 tataccaata agcccgtacg gagattgggg catttgcgta ataaagtgat gaatcatatc 1607281 aatcaaaatg tctttcgtta tttctggaga attggattcc aaatggcggt attgatcaag 1607341 aacgattgtt ccttcaaggt ctgttaaaat gccattaata taatccacac caacatctat 1607401 tccaacggag tatcctgcct ttttattaaa aacaagcatg acaggtcttc ttccgccact 1607461 tgattgtcct tgacctattt caaataccat actttctttc attaacgtgt ttacctgtga 1607521 tgagacagtt gatttattta atccagtcat ttcagataat tttgctcttg aaataggtga 1607581 atttttaagg atttctttta ataataactt ttgatttact tttttgacaa aggtttgatc 1607641 agcgatatcc acttcatcca ctccatttgt ttaatcttta aattaagtat caacatagta 1607701 catagcgaat cttcccttta ttatatctaa tgtgttcata aaaaactaaa aaaaatattg 1607761 aaaatactga cgaggttata taagatgaaa ataagttagt ttgtttaaac aacaaactaa 1607821 taggtgatgt acttactata tgaaataaaa tgcatctgta tttgaatgaa tttattttta 1607881 agggggaaat cacatggctc aatctcattc cagttcaatc aactattttg gaagcgcaaa 1607941 caaagtggtt tacgaaggga aagattcgac taatccttta gcatttaaat attataatcc 1608001 tcaagaagta atcggcggaa aaacgctgaa agagcatttg cgattttcta ttgcctattg 1608061 gcatacattt actgctgatg gtacagacgt ttttggagca gctacgatgc aaagaccatg 1608121 ggatcactat aaaggcatgg atctagcgaa gatgagagta gaagcagcat ttgagatgtt 1608181 tgaaaaacta gatgcaccat tctttgcttt tcatgaccgg gatattgcac cagaaggcag 1608241 tacgctaaaa gagacaaacc aaaatttaga tatgatcatg ggcatgatta aagattacat 1608301 gagaaatagc ggcgttaagc tattatggaa tacagcaaac atgtttacga atccccgttt 1608361 cgtccatggt gccgcgactt cttgcaatgc agatgtgttt gcgtatgctg cagcacaagt 1608421 gaaaaaaggg ttagaaacag caaaagagct tggcgctgag aactatgtat tttggggcgg 1608481 ccgtgaagga tatgaaacat tgttaaatac cgatttaaaa tttgagcttg ataatttggc 1608541 tagatttatg catatggcag tggattatgc gaaggaaatc gggtacacag ggcagttttt 1608601 gattgagcca aaaccaaaag agccgaccac ccatcaatac gatacagatg cagcaacaac 1608661 cattgccttt ttgaagcaat atggcttaga caatcatttt aaattaaatc ttgaagccaa 1608721 tcatgccaca ttagccgggc atacattcga acatgaatta cgcatggcaa gagtacatgg 1608781 tctgcttggc tctgttgacg caaaccaggg tcatcctctt ttaggctggg acacggatga 1608841 atttccgacg gatttatatt ctacgacatt agcaatgtac gaaatcctgc aaaatggcgg 1608901 ccttggaagc ggcggattaa actttgacgc gaaggtcaga agatcttctt tcgagcctga 1608961 tgatctaata tatgcccata ttgcagggat ggatgcattt gcaagaggat tgaaagttgc 1609021 ccacaaatta atcgaagatc gtgtgtttga agatgtgatt caacatcgtt accgcagctt 1609081 tactgaaggg attggtcttg aaattataga aggaagagct aatttccaca cacttgagca 1609141 atatgcgcta aatcataaat caattaaaaa cgaatctgga agacaggaga aattaaaagc 1609201 gatattgaac caatacattt tagaagtata acaggataag ctccagatcc tgctatcaat 1609261 accaagtcac tgaattaccc gtcatgattc ctttcctatt gcttgttgtt atgacgggta 1609321 acttctataa ttaggattta tttagagtga atggtttttt aaaagggcaa ggagtgaaaa 1609381 aatgaagtat gtcattggaa tagatcttgg aacgagtgct gttaaaacca ttttagttaa 1609441 ccaaaacggc aaggtttgtg cagaaacgtc caaaaggtat ccgctcatcc aagagaaggc 1609501 gggatatagt gagcaaaatc ctgaagactg ggttcagcaa acaattgaag cattggctga 1609561 attggtttct atatccaatg ttcaagccaa ggatattgac gggataagct attcgggaca 1609621 aatgcatgga ttagtactgc ttgaccaaga tcgtcaggtg ttacgtaatg caattctttg 1609681 gaatgatacc agaacaacgc ctcaatgtat aaggatgacc gagaaatttg gcgatcatct 1609741 tcttgacatc acaaaaaacc gtgttttaga agggtttaca ttacctaaaa tgttatgggt 1609801 aaaggaacat gaacctgaac tttttaaaaa aactgctgtg tttttgcttc cgaaagacta 1609861 cgtgcgattc cgtatgaccg gtgtcattca caccgaatac tccgatgcag caggaacttt 1609921 acttttacat attactcgca aggagtggag caatgatatt tgcaatcaaa ttggtatttc 1609981 tgcagatatt tgtcctccgc ttgttgaatc tcatgattgt gtaggatcgc tgcttccgca 1610041 cgttgccgcg aagaccgggc tattagaaaa aacaaaagtg tacgctgggg gagcagataa 1610101 tgcttgcggc gctattggag caggtatcct ttcttccgga aaaacattat gcagtattgg 1610161 gacgtcaggg gtcatacttt cctacgaaga agaaaaagaa agagacttta aagggaaagt 1610221 ccactttttt aatcatggaa aaaaggattc tttttatacg atgggcgtca cgctcgctgc 1610281 aggatacagc ttggactggt ttaaaagaac gtttgcacca aacgaatcgt ttgagcaatt 1610341 attgcagggg gtggaagcta ttccgatagg agccaatgga ctgctataca ctccttattt 1610401 ggttggtgaa agaacgccgc atgctgattc ttctattcgg ggaagcttga tcggaatgga 1610461 tggagcccat aatagaaagc attttttgag ggcaataatg gaaggtatca cattctcttt 1610521 acatgaatca attgagctat tccgcgaagc gggaaaatca gttcatactg ttgtttctat 1610581 tggtggggga gctaaaaatg atacgtggct gcaaatgcaa gctgatattt tcaatacgag 1610641 ggtaattaag ttagaaaatg aacaagggcc agctatgggg gctgcaatgc tggctgcctt 1610701 tggaagcggt tggtttgaat cacttgaaga atgtgcagag cagttcattc gtgaggctgc 1610761 tgcattttat ccaaaggcgc aaaatgttca aaaatataaa acactatttg atttgtataa 1610821 gaacatttac actcacacaa aggatctcaa tacagctttg aagagctttc gaaaaaacta 1610881 atgatgttat tgtctggaga tcaaccgaag aacaattaat gatcaatcat catcaaaggc 1610941 ctttgataac atggctgcct tcttttgaaa agatggtgag aataaggtat cgcaaccttt 1611001 aaacagtatt ggagtatcca gcagacaaaa cgaacgagtg gaaccgtatt ttgtcagcga 1611061 acacttcaag aagtggggaa gcttaggaat gccaatgggt aagatgtatg aaaccgcgct 1611121 aacgacggta gagggatctc ttgatttatg aagaaatagg aaggatgtta acacacaaat 1611181 aacccctcac attgacgtga aggggtgttt tttattgtta ctatacagcg gaaattttac 1611241 aggctagttg catgatttta gcttgttaag cagaatggaa ctagactctc catcatctct 1611301 ttctcattct ttggaaactg cattctgcta ggtttgctgc tttttttaac aaacagtgtt 1611361 tttctatttc acacagccat taaatcctct gttcgtcaca taaccgctct tactccaaat 1611421 tgacagttta tctgattttg cttcttgctc atctagtctg aattggtcta tgtattttgt 1611481 gttaggctca tatacatatg ctactctggc caatccctct ttcaataatg tctcttgaac 1611541 agatttgccg tcaacataaa cgtatgctaa cagtcttcca tacttatctc tgcgatcgcc 1611601 tttatcaaat tccagctgta gcttaccgct gttgaccaat tctttatttc gtttcgacgc 1611661 atcctcaccg tatggttgaa cacaagaatt tggtttcttc gtctcaggtg tatcaacgag 1611721 caagtagcga actgtgtctt tctttccgtt gtaaataacc ttaatcgtat ctccatctat 1611781 tgctctatct aatgtaacat tgaccaattt cttctgattt tttgaatgag gcgtgccagc 1611841 cttttgttct gtctgattat attcattaga gtgagtatct tgagagactt gctccgtccc 1611901 attagaatct gaatggtttt tggctgcgtg atttgatccg caagctgcca aagtaatact 1611961 taaaacgatt gcgatcatac tgatcaaaat cttcttcata ttgattccct ctttatcatt 1612021 ttctcttttc gcgattaaac atcatcatta taacgatatg gacatttttt gtgaatggaa 1612081 aacttcaagg gaacttataa cactccaaat tgccaatagt taacttcaca acgagatgat 1612141 caaaacatca ccatcacata gcggaaataa ataatcctga aaataatatt gactgaaaat 1612201 gcttttagaa ttatgataat atgagaaatg acaataatgt gacaaagaca ttactacaac 1612261 ataacaacta atagcttagg tttattctat tggttaaaaa tgtaaacggt tacaaatcca 1612321 gaggcgaaaa tctaagatag agatgacttt agttttgact caatatccac actgaaagag 1612381 cttattaagt attcttaaag gcaggggaaa tggatatgaa tgaacatcga aatcgaaggt 1612441 tgaaattaat aatgatttca gcaacttttg gagggcttct ctttggatat gacaccggag 1612501 ttataaatgg agctttacct tttatggcaa ggccagatca gcttgattta acacctgtta 1612561 cagaagggct tgttacgagt attcttttat taggtgccgc gtttggagcg ttgttatgcg 1612621 gaagattggc tgatcgatat ggccgccgta aaatgatcct taatctttcc tttttatttt 1612681 tcctggcatc actgggaaca gcgttagcac ctaatgtttt catcatggcg gtctttcgtt 1612741 ttttactggg gctggctgtt ggaggagcct cggcgatggt gccggccttt ttagcagaaa 1612801 tggcaccgca tgaaaagaga gggcgtatgg taacccaaaa tgaactaatg attgttggcg 1612861 ggcaattttt agcatatgtt tttaatgcga tcctcggtgt aacaatggca aatacgggac 1612921 atgtttggag atacatgcta gtcatttgtg ctgtaccggc tatcatgtta tttgccagta 1612981 tgcttaaggt accagaaagc ccccgatggc taatctccaa aggcaaaaac agtgaggcgc 1613041 tgcgagttct taaacaaatt cgagaagata aacgtgcaga agctgaatgt agagaaattc 1613101 aagaagcggt agaaaaagat acagcactag aaaaggcatc actcaaggac ttttctacac 1613161 catggctgcg ccgtctttta tggattggaa tcggtgttgc catcgtgaat caaattacag 1613221 gtgtgaactc gattatgtat tatggcacac aaatccttaa agaatctggt tttggtacaa 1613281 aagcggcttt aatcgctaat attggaaatg ggctgatatc agttattgca gttatatttg 1613341 ggatttggct ggtcggaaaa gtgagacggc gtccaatatt attgattggt ttggcaggga 1613401 cgactacagc gctcctattg attgcgattt tctcaattgt gcttgatgga tctatggcac 1613461 ttccttatgt agtgctttct ttgaccgttt tatttcttgc ctttatgcaa gggtgtgtag 1613521 gacctgtgac ttggcttgtc atagcggaaa tattccctca aaggttaaga ggacttggtt 1613581 ctgggataag tgtttttttc ctttggatat taaactttgt gatcggtttt gctttcccga 1613641 tcttgcttag ctctgtaggt ttgtctttta cattctttat atttgtggct ttaggtgtat 1613701 tggcaatcgg ttttgtgtac aaattcatgc cggaaacaaa agggcgtaca cttgaagaat 1613761 tagaagagca ttttcgttct cgacacgatc ataatactcc tgaacaatca gttattgagg 1613821 tataaatatg ttgaaaatct ctcttcttat aggagggatt tttttagttt cagaaaaaac 1613881 aaaatccctc tggtagaggg attttgattc agcattttaa gatgttctac acgtataata 1613941 ctggagttga tactttaaaa atctcgccat ctcttatata aaaacgaggg atgcggcggc 1614001 ttaatgtaga cacgacttca tagttaatcg tattgagcat ttcagccact tcatcaacgg 1614061 aaatctcggc tcctttttgc ttaccgtaaa tcacgacttc atctccttgt ttaccttcac 1614121 cgttttctcc taaactgacc atgatcatat ccattgttac tcttcccgcc actggcactc 1614181 gttttccgcg atgaagaaca aacccgcgat tggaaagggc acgagaatag ccgtcagcat 1614241 agccaatcgg gagtgtagca attacttcat taggttctgc gatgtatgta gcaccatagc 1614301 taacggttcg gggttctgtc cgcatggttt tcacataagc gatgcgtgcc tttaaactta 1614361 acgcaggttc aagcttaacg agatttagtt gtttaatata ggctgaagga tataaaccat 1614421 ataagccgat acctaaacgg atcatatcag cgctaaattc cggaaatgcg atagctgcag 1614481 ccgtgttgca catatgcacg gtgggcagct caatcccctg tttttttaaa aagctgagaa 1614541 aactgatgaa tttttcatgc tgcagctttg tgagtgttgt gtccggttca tcagctgtcg 1614601 aaaaatgtgt gaaaatccct gtccatctga ggaatttact tgcctttaag gctttcacta 1614661 cctctaaaag ttcttccttt gtgcgtacac ctaatcgtcc catgccggta tccacgttaa 1614721 tatgaatggc cagccggtta gcactcgctt ctttttccaa tatctcgttt gcttctttca 1614781 tccaatcaac ctgaaatgct gataatgtta tattccaagc tgctgacttc tttacacaac 1614841 taagggatgt aaaaccaagc acaaggatag gtgctgtaat cccagcttta cgtaaaacga 1614901 ttccttcctc cacactggca acagcgagct cactcgcccc gtgttccagt gcatggcgtg 1614961 ccacttctat agacccgtgg ccataaccgt tcgcttttac aacagccata attttgctct 1615021 tatgtggaat atgacggcgg atcgctcgca aattcttttt aacggcatca agattgactt 1615081 cgatccaaac ttctcggcaa agctttatca tcaacgcttc cttccttctt atggattata 1615141 aataccacct attgccgcaa gaataaatgt taattgttgg atgattcgat cttattttat 1615201 tcaactttat ttgaaatcat tcaacagcaa atccatgtga tacgagaagg tgcctatcaa 1615261 tgttcgaata atagcaagta cgggatacat gaggcttgta agtggggtgt taatggatgc 1615321 ggcgaccgag gattacaaaa atgattattt gttttgggac atttttttct aagggtagat 1615381 gataacgaga aatctaatca ggaaatactt accgttgtta tgaacattga agaacctttt 1615441 aaatgagaag ggctgaggaa attctgtaaa agataatcgg ttgaaaaggc agtcgattcc 1615501 ttgttccata aacctaacat cagagtatat aattatactc gtattcacaa aaatcgttta 1615561 agtaaggggt atacatgaat aggggagtta gttttcaaat accgaatgaa tatggaaatt 1615621 ttctatggag aatactgcag ccggtagaaa tagctaatta taggtggcaa acgagtgggg 1615681 aatcttattt tgttgtagaa ggagagctcg atgatgagga gctttttcat gactacgaaa 1615741 ttgttgaggg ggcagttttt gagcaacaat taaaaacgaa tcagtactat accattttcg 1615801 ttgaactgaa agcatttcca tatggaaaaa tggttaatca agtcaataca tatgaagagt 1615861 ttgctgacag tgattgcgaa cttgtccttt tgatagcaga taatagctac gtttcgattt 1615921 actgtaaaaa caaaaatatc attgaaaaac tttacttcaa tgctttacag catgattttg 1615981 aagacgttca atttataact gatgaaaatg acacaagaac aagccttact gtatgatact 1616041 caataaaaat taaaggagct agtacatgac aatgcaaatt aaaatcaagt atctagatga 1616101 aacacaaaca agaatcagca aaattgagca gggagactgg attgatcttc gggcagctga 1616161 agatgtaaca atcaaaaaag atgaatttaa gcttgtccca ttaggtgttg caatggagct 1616221 gcctgaaggt tacgaagcac atgtcgtccc tcgttcaagt acatataaga actttggcgt 1616281 tattcaaaca aattcaatgg gtgttatcga tgagtcatat aagggagaca acgatttctg 1616341 gttctttcct gcttatgcat tgcgtgatac tgaaattaag aagggtgatc gtatctgcca 1616401 gtttagaatc atgaagaaaa tgccggcggt tgaattggtt gaagtcgagc atttgggaaa 1616461 cgaggataga ggaggactcg gttcaacagg tacgaagtaa acaaaataaa tccttggctg 1616521 tcttcatgct gtgtgattga tcaatggagg tttcagccaa ggtacatata aatattatgt 1616581 ataaaatgaa tattttaata cgaaggattt aattaaaaac aaagtttaaa aagggaagtt 1616641 ttgaaaaagt gaaatagtaa taactaaagt cgataaagaa cctaaagatg tcaaagaaac 1616701 aatttttctg gtgctttgct tttttgaagg tttacttagc tcgtggataa ctgcccccca 1616761 taaaagcatg gatgctaaaa ttataatact tatatacata aagatgctcc ttttattata 1616821 tttacagttt ttacattttt atcgatttta ccacatttag gattgagttg tcgatgaaac 1616881 aagcatctct ataaagaaat acttttatct aaatttttat aaatagggga aggcaactaa 1616941 aaactagtaa tgccactaat aataagccaa gttaaatgac ttgtgttcat taataattga 1617001 attttacagc agccatgagc acaaaaaaat ctgagttcgt cgataaatat cataaaaaag 1617061 cccccggtat gtcgccaggg aataaataga cgtttaagag atttagtgat gttttttata 1617121 tgattcgaca aaatcataat aatgatcatc gtcatcataa tacttttttt cgtaatgata 1617181 atcgtgatca tcgtaatact ttttatcatg gtcatcatac tttttgtcgt aatcataatg 1617241 ttttttatca tgatcataat acttgtcgca atcataatgc ttcttatcat tgtcgtaata 1617301 ctttttgtaa tatgtttttt tccaagtata atactcttct ttatattttt tataataacc 1617361 caattaaatt cctcctttat gttattcgaa tttaatttat gaagtttaaa tgatatggta 1617421 tggtcaaatg aaataagaat agtaaaaaga ggctgtttaa aacactttct gaaaaacaaa 1617481 acggatagct gtttatgaaa ataagagcga gagagagcac tcaatcactg taaaataata 1617541 gtaaagtgta tagagagatt agtatacgta aaaagggact ttctcattga agaatatttg 1617601 aacgttatgg ttaagattca agagctctat gatgtgattt ttcacactgc ttttgaagga 1617661 tttagagtta gacatcaaaa acaaacagca aaaccggcta gaaacagatc atataaggaa 1617721 tgaaccgctg ccaaatatca taaaaaagtt gttaatgatc aaatgaatga aattagagag 1617781 aatttatttt aaagaaagcc caattgcaca tggacaaatg acaattgata ttgaggtaaa 1617841 atacaatgca ttaaatcaga aaaagctatt ggaggattta atgtgtttag acaatttcca 1617901 atttggtata cacaaacacc tgactatttg aatttttatg taccgcaata tcaaaccatt 1617961 tcgtataatc ctcaacaatg ttatcaacgg tgtatgtacc aaactggcgg taactatgag 1618021 ctatgtgaca gactatgtta tggagaaata caggtgtaaa agagggggat taactcctct 1618081 ttaaacacac agtgagtgga ataagatcct cactttatct gcaagtgctt agtatttgcg 1618141 ataatattgc attcgtaata aattatgctt agcaactgaa aatgaaagaa ggatatgaat 1618201 agtcatgacg caattcgata aacaatacaa ttcaattata aaggatatta tcaataatgg 1618261 aatctcagac gaagagtttg atgtaagaac caagtgggac tcagatggaa caccggcaca 1618321 tactctaagt gtaatcagta agcaaatgag attcgacaac tcagaggttc cgattttaac 1618381 gacaaaaaag gttgcctgga aaacagccat taaagagttg ctctggattt ggcagctgaa 1618441 atctaatgat gttaatgatt taaacatgat gggcgtccat atttgggatc agtggaaaca 1618501 agaagacgga accatcggac atgcatatgg atttcagctg gggaagaaaa acagaagtct 1618561 aaatggagaa aaagtggatc aggtagacta tcttcttcat caattgaaga acaatccatc 1618621 ttcacgcaga cacattacaa tgctgtggaa tcctgatgaa ttagacgcaa tggccttaac 1618681 gccatgtgta tacgagacac aatggtacgt taaacatggg aaactccacc ttgaggtaag 1618741 agcacggagc aatgatatgg cattgggaaa tccattcaat gtattccagt ataatgtgtt 1618801 gcagcgcatg attgctcaag tgactggtta tgagcttggt gaatatatct ttaacattgg 1618861 ggattgccat gtgtacacac gtcatataga caatttgaaa attcaaatgg aaagagaaca 1618921 gtttgaagca cctgaactat ggatcaatcc tgaagtgaaa gatttttatg actttaccat 1618981 tgatgatttc aagttaatca actataaaca tggggacaag cttttatttg aggtagcggt 1619041 ttaatgctgc ctttttattg tgcagtgaat agatagcagg tatcctaatt tcattaagca 1619101 atctggaaga tgaataaaaa ttgaaggaca aacacgtata atacataaaa aagattaact 1619161 ctacagttaa tcttttttat tcagaagaaa atatcctaac tttgaaacta aatacaaagt 1619221 aaaagcaatc attacagttc tagatattac aattccatga atagctagat catatccagc 1619281 aggtatcaac gcatttgtat tacacataaa atatatagat attagaagtg ctacaataac 1619341 taaaatcatt ccaaaaagac ttgttttttc atatttcata ccaatttcca cccttattaa 1619401 agttaggttt aaacaaaaga gctgaagaaa cgaactatga ccagtatgct ccaaggaaaa 1619461 ccgccagaca atgctggcgg ctttttgctg cttcgtttat ttattaacag agatcgtaac 1619521 gttatttcct gcaactgaaa cctttgcgaa atcctgtgta tctaccacag gagtgacggc 1619581 tttattgtcg atagtgatgt tgttaaaaga ggtcgaaaag gttgctttga tcgcatcacg 1619641 ctggctttca tacgaaacag ccgcggtagc aagtgttttc cattttgaaa tcgtgccgat 1619701 gttggttcct tgaatttctg tgataatccg tccggtgtag ccgtcattgt tcgttcccca 1619761 aagggtcatg cgcgtattgc cgcttaaatt tttatagatt gtcatttgga ctgtgcttcc 1619821 agggcggaag cctttattgt atgtgaattt gtcttttcct tcgatgtacg tttcttcatt 1619881 tttggaccca accttcatga ggggcttcca gacgttgtat tgtttgctgt actgaagccc 1619941 gatatcggct tcagttccgc ttgttgccct aaagccagaa taaatatagg gagtagagac 1620001 cgagtcgttg tttttgacag tttcaggaag cacgatttta gctgtaaaaa cggcgcccgt 1620061 actgttcagg tagacacggc cgccgattcc gttaggcagc tcggatgctg cttttgcgac 1620121 ttgagcgtct gccgcgggta aacctggtat acctgatgaa agggttccga aaagaactgc 1620181 tgttcctact gcacctgcaa tcaatacttt tttcaccaaa attccccctt ttgatagtgg 1620241 tttcgccatt tattatacct tattttggaa ctggatttac gtatataaat cgacaaaata 1620301 tttcattttg aatgatgtaa ggtcgaaacg cttcgccaat ctgaaagcta tataccttta 1620361 tcagaggaaa gaatgagatc acattcgttt taaccgattt gaaattttcc tcaaaataaa 1620421 agtacaaatg cttaaagaaa cgattattaa aagaatgccc gctatcgttt ccaagcctgt 1620481 aaaaaagagg tgacgtttca tcaatgtctg tccttgtaaa atgataaaag cacagatacc 1620541 gactaagaaa agaaaacaaa tacttaggat tgctaacgct ttacgtgagt atgttttcat 1620601 ttcatcttta aaatacagca atacgaaaat aaagcagata acattggcta ttgttctaat 1620661 cacctcaaag cttttcatga caactgatat aaatagacaa agtaaaatga gataaaatac 1620721 gatgtttcta tacaaaaaac ctctcctttt atgtaggatc ctcaaagagt ttataaaagt 1620781 ttctttgtaa ctgcaataaa ttgaatgcgc tcacttatga actaactaaa ctatgtacta 1620841 aatattcact attctttttc agattcagtc accaaggttt tcatagaaag ggaagcttca 1620901 gaaatataca tatagtgcac aaacaaaaaa gacccggcaa tagccggggg aaagtaaaaa 1620961 cgaggagatg ttaatggcgt ttagtagtgt tttttatgct ttttatactc tacaacataa 1621021 tcatagtctt ttttatcgtg atcataatat tttttatcat agtcatcata ttttttgtcg 1621081 taatcacagt cataatcttt tttatcatat tcgtaatact tcttataata cgtttttttg 1621141 accgtataat actcttcttt gtattttttg taataaccca tatatactcc tcctttattt 1621201 ttactacgct ttattatacg gcgagtagat tttgcggctt ggacagttaa aatcatagaa 1621261 ggaaaaaagg gctgtccaaa tgatagaaaa agacagatga cacaaaaaca aatcaaaata 1621321 aagagccgat ttttcatcgg cccaaacgat ttatcctaca tttgtttgtc ttctttgttt 1621381 tctgagtcat tttttctgat atcctgagtc agtccgcttg ttgcttgttt aaattctgat 1621441 aaggcttttc ctgctgcacg gccaagcgcc ggcagtttat caggcccaaa tactaaaaaa 1621501 cccacaaaca aaataacgag tatttttgtg aagcttaatt ccatatcctt ttccccctga 1621561 ttgaagtaca accttttaaa caaattataa gagatagcag tacaaatggg aatgcattta 1621621 ttttgaacat tttaaaacca gcacaaagac ggattcataa aacggctgct gctgaatata 1621681 atgtccaatg ccacctgcct aagaagcagg aggcaggctg gatcaattat gtagctctgc 1621741 cggaaatgat acaaacgtag cggctatcat tgacatagag gagtggtgta gctgatgaga 1621801 ttcactaagg tagttggatt tttgtctgtt ttagggttgg ctgcggtttt tccattaacg 1621861 gcacaagcag aaaaagccgg aactgcgggg gctggagagt gggataagtt ggggacttac 1621921 acatatactt actcaagtcc gacggtatac tcgaccggag gagattttag agtgtgcctt 1621981 tcaggaagca ctcctttttc tgtttcactg cacttatatg aggatgatcc cggtgacaat 1622041 cctgatgatt atgtaggggc aaactatttt tcacccggag aatgccacac ctttggcagt 1622101 attggaaaat ttgtagatgg gagcaataac aaggccgagt tctttgttac cgattactct 1622161 ggtaaatcta aaactgttac gttttatgat tgatggactc aaattgtgaa gtataaccct 1622221 tggaaaaaaa caaaaaagag agatacctct ctctttttta ttcttcgaca gccttacgaa 1622281 gccgttcatt tacaatgcca gtccagccgc catccatctt accgcgaacg acggagcttt 1622341 tctcgtttgc tttgccgatc acttcattcg gctctttcca gccgctgtga ataagggtaa 1622401 accctgtctt ttcccccaag tcttctaatt gaaaggtaac gacccatcct tctgtatccc 1622461 attcaaaaga aagttcagtt ggagcttgaa cagccaaaac tttacaaggg gacggcccaa 1622521 acggcgattg taagtgaaat tcttgtcctt ctttgagctg aaagtcattg ggcataaacc 1622581 acttggcaat gccttctgaa gtagagactg tctcccagac tttctgaatg ggagcctcca 1622641 gagtaatgct ttttgtaata tccggtaatg cattttcgtt gttttgagcc atttcgttta 1622701 cctcttgaca tatgatgttt tttcaattca atcatataat aactaataag atcatgtcca 1622761 tagcgtgcat tatttatgct agagctgctg ttgaacagcg tgtcagtcgc cagtctgatc 1622821 tgtgaatggg agaattctgc atgcgcgaaa aagagagaga ggtgtatgtt gtcatttcgt 1622881 tcattcttgt ttgcagccgc aactgttatg tttgaactgg gattcctgtt cagccaattt 1622941 attttgcgat ttttgtttta atagtaaatg agccattttc taaaacagga ggttttttat 1623001 gcttggaaaa atcaaagcag ccattgataa tagtccaggg aagccggcca gaattttagt 1623061 tagtgaaaaa gcgtttcagc aattagagga agaaatgcgc tttgtttacg tttccaaacc 1623121 gaaaacgata atggggattc ctgtggaagt ttcagatcag gcagaaagct tcaagctgga 1623181 attttagttt tcccagactg ctaaaaggct cattttgtgt taattatgca aaatggtcag 1623241 gttgatttct ttaaaagcat gatgaaatgt tcatcatgct tttttattga gaaaaaagac 1623301 gaacataaaa aataggtata cgggaaaaat aatcctatta gagagagggg aactgacaga 1623361 tggataacat gatatcaaca cttactgact ggaatgtgtg gtttcaagcg ttagtagtat 1623421 ttctcgttcc atatgtaatc tataaagtgt ttacttggat tcatgtataa gaaggtgcaa 1623481 tgatgaggtg gcggaacaat cagtacaaaa cacagaagca gcataaatca gattattcga 1623541 cagctgaaaa gcaggatcag gatgtgttaa ccggtaacat cggatacgac ttagaacatg 1623601 taaaaagaaa aataggacat aacggggacg ttcatttccg tgagcttgaa atcactcaat 1623661 tacatgtgaa agcggcattg atctttgttg aaggactgtc tgatcaggac ttgattaata 1623721 aaggactatc agtgttagtc atgaatcaac ctaatcaggt aagcgatgaa atttctcaat 1623781 ccggcaaagg tattttaact tcgaaacaga taaaaaatca aatcgtatca atcggtgatg 1623841 tcatagattc agagaaaatc agtgatatcg tgttgaatgt tttcatgggt tcgacagcgc 1623901 ttctcatcga tggaataccg caggcctttc ttctgggaac tgtaaaaaaa caaaatcgaa 1623961 gtatcgagga gccgctttca gaagcgcttg tcagagggcc gcgcacaggc tttacagaag 1624021 agttgagtac gaatacagct cttttgagac agcaaggaaa aaatgatcaa ttaacattgc 1624081 agagatttga agtaggaaca cgattaaaaa aggatttaat tatcgcttat atgaatgaca 1624141 ttgcagatcc aaaagtagtc gaggaagtaa gaaaaagagt gagagggatt gagatcgatc 1624201 atttgccgga gtcaggctac gttgaacagt taattgagga taattatttg agcccgttcc 1624261 cgcaagtaca gagtacagaa cgtcctgatc gcgtcataag cggattaatg gaaggaagag 1624321 tagctattct gcttgacggc actccgtttg ctttgattgt tccagtcact ttcagcatga 1624381 tgcttcaatc gcctgaagat tattatgaac ggtggttccc gagctcgctc atcagattgc 1624441 tgaggttcat cgcagcaatg ataacgttat tcgcacccgc tttatatata tcatttattt 1624501 cttttcatcc tgggttaatt ccgaccaagc tggcgatttc aatttccggg acgcgccaag 1624561 gtgttccgtt cccatctctg attgaagcct tatttatgga agtcgcgatt gaaattttaa 1624621 gagaggcggg gcttcgtttg ccaaaaccaa ttggacccgc aataggcata gttggcggat 1624681 taatcatcgg ggaagcagct gtgcaggcgg ggattgtcag tccaatcatg gtcattgttg 1624741 ttgcgctcac agcaatttct tcatttgcca tcccgcatta tagcacaggt atagcacttc 1624801 ggatgcttcg gtttggcgcg atgttttgtg cggcggtgtt tggattgttt ggagtcatta 1624861 tgtattatct gctgctaagc agccatgtcg taaagctaaa gagctttggt gtgccatacg 1624921 caagtccggc agtgccctat cacttaaaag attggaaaga ctttgttatc agaatgcctc 1624981 ttttagtcat gaagcgccgg cctaaaatga tgaatacaga taatacaaaa cgggtgaagt 1625041 gatgaactcg acaggatggt gataaagtct catgttcagc ccaaccagta aaatcacaac 1625101 cgctcaggca acgattatca tcattaatta tatgcttgct gccggagttc ttacgctccc 1625161 tcggacagta acagaacaaa cacaatctcc tgatggatgg atttcagttt tattaggcgg 1625221 ggtcctagcg gtaatagccg ggatgattat agctaaatta agccagcagt atcctaagga 1625281 gaccttttat gaatactccc gacatattgt aggaaaatgg ctcgggcatc tgatcagtat 1625341 tgtttttatt acttattttc tggcactcgg tgcatttgaa gtcagagtca tgtccgaaat 1625401 cgtggatttt tttctcctcg aagggacacc ttcttgggcc atcattatga cagttctttg 1625461 gattgggctt tattcaatta cacaaggcct agatccgatt gcacggcttt ttgaaatgat 1625521 ttttccgatt acggtcatca tctttttaac gatagccctc atgagtttag gcatatttga 1625581 gatcaacaat ttgcgccctg tattaggtga tggaatcatg ccggttctta gaggtgtaaa 1625641 gacaacgaac ctttcattta catgttcaga aattatgttc attttagtag catttatgaa 1625701 aaagccgaaa aatgcggtga aagcagttgt gatcgggaca ggcgttgtga ccagttttta 1625761 tatgattacg atgattatgg tcatcggtgc actatcagtt gagggagttg tgacgagaac 1625821 atggccgggg cttgacctga tgagaagttt tgaaatacct ggtttaatat ttgaacggtt 1625881 tgaatcattt ctgcttgtga tttggattat gcagcttttt gccacgttta ttatcacttt 1625941 ttatgcagct tccctgggag tctcacaagt ttttaaaaag aaaccccttt catgtatgtt 1626001 tgggctgctt cctgttatat atatcctctc ttgcatgccg aaaaatgaaa atgacgtctt 1626061 tatattgggc gatacggtca gtcatatcgc tttgtatata tttggcgctt tgccgatttt 1626121 gctgttagtc atttcgaaat ggaggaaaag aggtgaaaag taaactaaaa cgtcaattgc 1626181 ctgctatggt catagtatgt ctgctgatga tttgcgtaac aggatgctgg agcagtcggg 1626241 aaatagaaga tctgggtctc acattcgcta tcgcaattga taaaggaaaa gaaacgaaca 1626301 ctgaaaaaga gttaaaagaa gagggcggga gctatccgaa aaaagacaac attacgctga 1626361 cctatcaatt tgttaatgaa aaagcggcag gcgcgggcac aagcggggga ggcggtagcg 1626421 gacaaggagc gcaaaaagcg tacattaata taagtgaaac aggggattca ttacagcaga 1626481 tcggaagtga ggttgcatta agacgggacc gagaagtgtt tagcccgcat ttaaaagttg 1626541 ttgtcatgag tgaagatgtg ctgcacacat ttcctatcga cgaaatgctg gatcaatttt 1626601 ttcgtgataa tgaaatcagg ctgagctgtc ttgttttatc tgctaaaggg gaagcaagag 1626661 acgctctcca gctgaaagag aacggagaaa ttccggcatt tcggctgatt ggattaggtg 1626721 aaaatgaaca taaagtttcc agaattcttc cccctatgac actcgcgaaa ctaattggaa 1626781 aactgcattc tggcagcagc tttttactgc aaaatgtggt tgcggcgaat ggagcggtca 1626841 agtattccgg agcagctgta atcaacggaa aatcgaaaaa aatgataggc accttaaatg 1626901 aatatgaaac tgaggggatt acatggatta gaggagaagg gaaaggcgga gttgtcaaaa 1626961 gtcatgataa aaagagccaa cagacgttag cgtacgatat caataaaatc aaaagcagaa 1627021 ttcagccaat cgtaaaaggg aaagatattt cattccatgt cgatattgaa tcagaaggcg 1627081 atttggttga aaactggaac acaaaagagg cgttggacac ccagtttata gatcgtctcg 1627141 aaacgactat tgaaaacgag gtaaagaaaa tagttggtca ggtattaaaa aaaattcagc 1627201 atgattataa agcagatgtt gcgggttttg atgaatcttt tagacttaca tatcctcact 1627261 tatggaaaag ggtgaaaaat aactgggatg acaccttcag taaagccgac atcacataca 1627321 gtgtgaacgt cacaattact catttcggca cggttaaaac tcagtaatga atcccaagga 1627381 agagaaggaa acctctcttc tcttttttat gcatttatta ggataaagat actttttttg 1627441 gagagatata cacttttcaa atcgaccaat atgctaatat aggaattgct tgaaatagaa 1627501 gggagaaggg gctgtgaggc agaaaccgat ttatgtagaa atcgaaatga aatctgatct 1627561 ggatacactc tgggaatata cacaaaaccc atcactgcat aaggaatggg atctccggtt 1627621 ttcaaatatt acgtatttga atagtcagcc atgcgaaaaa cagaagtttc tttacgaaac 1627681 aagggtaggc tttggattaa aggtgtcagg tacaggagaa accgtcggtg ttttcaacaa 1627741 atgttcatct gaaaggtctt cttcactggc ttttggctct gatcatccat tatctctgat 1627801 tcggcatgga agcggctact ggaagtatat acagagagaa aatgggaaaa tgacgttttt 1627861 aacacagtac caatacaaaa cagcctacgg actgctggga agatggattg atcgtttatt 1627921 atttcggccg ctgcttggct gggcgactgc ctggagcttt gatgcattaa ggctttgggt 1627981 agagcaaaat aaacatccga agcgcttcat tcgatctgct atcatctatg tgttcatgtg 1628041 tctgtttttc agcctgtttt ggttctatca aggctttgca ggtgttaaga caagcatatt 1628101 gacaggaaca gcggagatag gcttagctat tttgtggctg cttcctttaa aaagaaaatg 1628161 gatcattcat ggtgtccagg cttgtatttt tgctgggttt gcttgtctag gttccgaaat 1628221 attcatgtgg gttctattga gtgtgttttc cgctgcaagc ggcgctctta gcctgcagct 1628281 ccccagtgcc aggcgcacaa aacgaaagag aaagaagtga cattgtgagt tcgatttatg 1628341 aaaaatcaat tattaactat catttgctgc atcccaagct gcagaaacgg taccaattag 1628401 acgggtctca tacattcagc gggacgggaa cgatgtcaga aataagcgga ggctcttttc 1628461 tggttagaat gctgttaaag ctgggtgttt ttttcagatg cttcttttca gaaagaggca 1628521 aagacattcc atttacaata caaaatagaa cttgtctttt gaaatcgcaa catacaggaa 1628581 tagaatggaa tcgtacattt ttctttaaag gcaaaaaacg tttctttgat gcgttaatga 1628641 tatatgacga gaaagaaaat agaatacttg atttcttcgg caaacctcat ctgctgctgt 1628701 ctgttttgac gttcgaggca tctcttgacg gctctcttac gatcacatcg ggaaagcaat 1628761 ggctattgat atgcggaaaa agaatcccgc tgccgaaatg gctgaccggt acatccgaag 1628821 tttgcgaaac gtttgatgaa aaaaagaatt gtttcaccat tgaagtgcat gtgcaaaata 1628881 caattcttgg cactcttttc ttttataagg gaacgtttca ggaggaagag agagaatcat 1628941 gaaacgaaat ggcatagtca gtgcgctttg ttttattgga tttcttgcag cagaagcacc 1629001 ggatatttca gtggcagagg cactcgtttt gttatccatt ctatttttcg tgccgggaat 1629061 ttttcctttt gtttttcgtc aatctccggt tcgtgctgct cagtttatgg aaaacgggct 1629121 aatccagtgc tatcctgtag ccgcattctt tgcggtgctg gctctagtga cggaggttgg 1629181 gggtttcgca cttatctggt ggatgtacac agtttttaat gcattgtatg cgatcctccg 1629241 cctttgggaa acaaagatac atagaatcga agagacatca gttttgttcg gtcttattta 1629301 tttggcggga ggaggatttt ggttttttgc ttatgctgcc catttgcaga tcatgcaatt 1629361 tggccctctc atcattttgc tgactgctgt ccactttcac tattctgctt ttctgatccc 1629421 gatcttcaac ggtttactcg gcagaaccat tagaaaacat cggatgttgt acagttggat 1629481 aacatgggtg attttgcttt cgccccttct tatcgcactg ggcatcacat attcaaaaac 1629541 acttgatgtc attgcggtta gcatttatat ggcggcgatt tatcttcatg catttttggt 1629601 gttcacggca gcttttcgca ccaagacggg gacatttctt attcggcttt cttccgctgt 1629661 tttaatgata acgattgctt tctcgatgat ttattcattt ggtgtctttc ggcaagaagt 1629721 tacattgacc atcaatcaga tgatttggat tcacggtttt gtcaacgcgt ttggtgttat 1629781 cttgcccgct ctcatagggt ggagaataga ggatgcgaaa ccttttgatg cagacagtgt 1629841 aaagacattc agccgtatct acggaaaaag aaagattgga gaagaatttt tagctaacat 1629901 tcaagctgaa aataacgctc ggtacagcgg acttgtggat gatatgggca gcctgcgttc 1629961 aaaagatttt tcaccagaaa aactggcgcc gctcattctt tcgttttatg aacaaaccat 1630021 cgaatacaat attaaagcaa aagtaacatg gagcacgtgg tttcggccgc ttgcaattat 1630081 ttacgaatgg ttcagcagaa gaatcggcca aatacatctt tcgacgaacc ctgactggta 1630141 taggatgtac agcaagataa aaggtgttca ttcgaaaaaa gacggaaggg aaagagtacg 1630201 tgcctggatt agaacaaatg aaaaaaacga aaccattttt accgctcttt attcagtgta 1630261 tcgttcaaat ggagaggggt atatgaatat ttctttaccg cttccattca gcagcatgac 1630321 aggtatttta aaaccatatc atcatcagga gaagctggtt ttaacaagca ggcggagaaa 1630381 aagcagagcg ggggatgagg ggatttatct gcaaacaaga gcgggaactt gtccgcttcc 1630441 tttatctgaa acctttctga tagaagctgt acatgacaac aaattaaccg ctgttcatca 1630501 tatgtggctg tttggaataa aatttctaac tgttcattac agcattacac atattaacca 1630561 gcctattgaa agaacctaac acaaagaaga agcttcgtct gccagttgta atgagatgaa 1630621 ctgttttaaa attctgcacc gcatcaagac aggaaaggaa gggtttatgg tgttttatat 1630681 cagtttattt ctgattcttt ggctggctgc tgggtttgca gtgggaatga aacaagtgta 1630741 tgtcgatcag ctgtttgata aagctgtgat cgaaagactg gaaaaagaag cgaatgatca 1630801 tggacatgct gaccggatga tcaaacagcg cgtcctttat attgcagcag tgacagtaag 1630861 cgggtttatt tctgtttatt atgaaatgaa aacaatcccg caaaggcgaa acataagaaa 1630921 aattgaaaaa aacatcatga aattaaatca agcaaaaaaa cgaagaatga agagaaaata 1630981 aaaagtgcac aggccaaagg gcaggtgcat ttttgttttg tatggaaaat gggggaggtg 1631041 gtgccagctt acttttcata aattcaaaaa tgagaagaac agcgcccggg ctaatggtat 1631101 ataatattgt gaatttaaca aaaatttaac aaggaggacg agagaattcg tgctaaagcc 1631161 tcaaagagac ctacattctg ttgatttgga cttagaggcg gagtagatga aaccggccaa 1631221 agtatccctg ctccgccgtt tgctccattc cttgaagcat gttgattgta acatagccaa 1631281 acgttttcca tcaactatta aaattgtaaa attattgatg atttttatgg tgtttactcc 1631341 gatttcttca atttatgctg aagatgtata tcagaatttt gaggaattaa aaaacaatga 1631401 agatccttct gattatggcg ttgttacgaa agaaaccgga agccctgttc ttgttttagc 1631461 tattcacgga ggaggtattg aaggcgggac aagtgaagta gcgagagagc tcagcaaaga 1631521 gtactcgatg tatttatttg aaggcttaaa atcggcagga aactcagtcc tgcacattac 1631581 gagcacacac tttgatgaac ctcgggccct taaaatgacg ggaaatcatg aatatgtcat 1631641 ttcattacac gggtacgcag aagaagatca gcagatcgaa gtcggcggta cagatcgcgt 1631701 aagagcggca gatttagttg agaaattgca gcatgccggt tttcctgctg tattgctcaa 1631761 tatggaccat ccgcatgcgg gcgttagtcc gaataacatt gcaaataaat caaaaacagg 1631821 tttaagtatt cagatagaaa tgagcacagg gtttcgaaag tctttgttcg gcatcttttc 1631881 tttaaaaagc agagctgtta ctcaaaatga gaggttttat gagtttacag aagtgatgtt 1631941 ccgttttctc aaaaatagct actgaaaaat aggaggcgat aagacagcct cctattcctt 1632001 atgcttctct ttcgtttcgg gaaacagctc gtccgcggct tccgtttgat actgcaacgt 1632061 gttatctctc gctgacagtt catttcggaa attttcatca agcacatttt tcagtaaata 1632121 ccgatgaaaa aagtattcaa aaacagtaag acaggcagcg gaaaggagag ccgctccaaa 1632181 tggtgagaaa tcgtttcttg tttgggttaa aacaaatacc caaagaataa cgaatgaaag 1632241 gccaaagtca gccaatgaag ctgtaatatt gtttgttctg ggtaagacga gcatgtcacc 1632301 agaaagatag gaaacaaaac ctaagaaaag tgcaataaac atcacactta aaaaggatgc 1632361 gtgatagact ctgtccaaaa tcacatataa aagggcgaga gtgaaagcaa tctttgaagc 1632421 aagcgcaatg atatgtttca tttgaccacc taaattgtta ttttttgaag aaaattcttg 1632481 ggcgtaaaca aatgataaat aatgcaattc aaaaccattc ataatggtca tgttactatt 1632541 ttaaacagtc cgtttttgtt tacactggta tttttttcag ctgtatgaaa ctttcttatg 1632601 aaaaaagtcg tatatgtgga tgatcagctt tcaagggggg aatgatttgt ggagataaaa 1632661 ggaatcaatc acttgctatt ttcagtttcg catttggata catcgattga tttttatcaa 1632721 aaagtgtttg gtgcaaagct tttggtaaag ggaagaacaa ctgcatattt tgatatgaac 1632781 ggcatctggc tagcgcttaa tgaagaacca gacatcccga gaaatgacat taagctttct 1632841 tatacccata ttgcttttac aattgaagat catgaatttg aggagatgtc agctaaatta 1632901 aaaagacttc atgtcaatat tctgcctggc agagaacgag atgaacgcga tcgaaaatca 1632961 atttatttta ccgaccctga cggccacaaa tttgaatttc ataccggaac ccttcaagac 1633021 aggcttcgat attacaaaca agaaaaaacg catatgcact tttatgatga aacggccttt 1633081 tgatagcaca accatatttc atataaggtt aaatttaaag aagggtgttg gtggagactt 1633141 tatgtttggg gaaggtttct acccgacttg ttcaacgatg ccatatcttt tgaactgcac 1633201 aagtgattgg gtgaaggtga aattgaaata cacattacat tacattttat atgaagaaag 1633261 cgagctgttt tatcaaatgt tgaactaatt aaactatgta ctaaattttc agtatatttc 1633321 aattgctttg ccccttaata aatataaaac cgcatccttc cacgacctaa aaaatgaaac 1633381 gtttttaaga agatggcgtc taatattcta aatgttcata ttttgataaa agtttcctaa 1633441 aggaaagaaa atttcttgac ttcaacaatc ttttggtgga taattatggt gtaaacatga 1633501 tgttcttttt cctcctattc gggctcgcac ccaaaagtca gggcgagcct gctttttttg 1633561 aacaacaaac cccctctccg taaaggaaga gggggttatt ttatgcatct gatagatcaa 1633621 tagattaatg gacggttctg aacacgccaa tcactttccc tagaatgctg acattctgca 1633681 aaatgatagg ttccatcgtt gggttctcag gctgcaagcg aatgtgggta tcctctttat 1633741 agaatcgttt tacagttgct tcatcatctt ctgtcatcgc aactacaatt tccccattgt 1633801 tcgctgtgtt ttgctgttta acgatgacat agtccttatc gagaatacca gcatctatca 1633861 tactgtctcc cataatctcc agcataaata catgctcgtc tggaggaacc atgcggtcag 1633921 ggagcggaaa atattcttca atattttcta ctgctgtaat aggagatccc gccgtgactt 1633981 tcccgatgac cggtacatta acgacctggc tttgcggaat gtctacttct tcatcaagaa 1634041 tttctattgc tcttggtttt gtcggatctc gtctgatcag cccttttgtt tccaaacggg 1634101 ccaaatggcc gtggacagta gaactggacg caagcccgac agcctctccg atctctctca 1634161 cggaaggcgg atatcctttt gatttaacct ctgctttaat aaaacggagg atatcaagtt 1634221 gcctttttga tagcttcgtc atttttcgca cctcaaaacg tcgattttaa gaagattata 1634281 gcatgatttt ccttacagta caaacatagg ttcgaaaaaa caattgacag aaacgtttgt 1634341 tcgtatatac tgaaattata aaaatgcgaa caaacattcc tgttggaggt tatgatcatg 1634401 agtaaagaat ctattatttt tgtcggtctg tttacagtga ttttgagcgc ggttatcctt 1634461 atgctgtcat atacaagcag cggccaagag cttaatcagt atgttaaaat agaagtccag 1634521 caaggcgaca cactctggtc aattgctgat caggtagccg atacaaaaaa gataaacaaa 1634581 aatgatttta ttgaatgggt agctgataaa aatcaacttc aaacctctga tatccagccg 1634641 ggtgatgagt tagtgatccc attgaaaaag aagcatcagg atgcatatga attagcaact 1634701 gtaagataga gaggaaagag agataaaatg aaagcactca tttatgcccg tgtaagcaca 1634761 aataaagaac agcaggaaac gtcattaaag cggcaggagg aggagcttac ggccattgca 1634821 gcggagaacg gcatggaagt ggtcaaagtg atttcagaaa aagccagcgg atatgaaatg 1634881 gatcgggatg gtgtatttga gctgctcgat gagattaaga acgctgatat tgatgtcatt 1634941 ttggttcagg atgagacaag gctcggacgg ggaaacgcaa aaatcgcact gcttcattgt 1635001 atttatagag aaggtgtgaa agtctataca acggctcata gaggtgaact ggagttatcg 1635061 gaggctgact caatggtctt ggaaatcgtc agcattgtgg aagagtatca gcgaaagatt 1635121 cacaacatga aaatcagacg gggaatgaaa cgtgcagtaa aaaacggttt taaaccgcaa 1635181 aaaaacttaa aaaaccaaca tgggaacagt ggaaaagaaa aaatagaggt gccaatctca 1635241 gagatcgtcc gcctgagagc gaataaactg acgtttgctg aaatcgcggc taccctaaga 1635301 gggtttggct atgatgtctc taaagcaacc gttcaccggc gttttcagga atacatagag 1635361 aatgaagaga ctgcagagtg aatcagttgt aaaacttttt ttgatctagt actatataga 1635421 caaaatgcaa taaaggagtt taacatgatt tcaaacgcga aaattgccag aattaatgaa 1635481 cttgctgcca aagctaaagc tggcgttatt acagaagaag aaaaagccga acagcaaaag 1635541 ctccgtcaag agtacttgaa aggttttcgt tcttctatga agaacacgtt aaaaagtgtg 1635601 aaaatcattg acccagaagg caatgatgtt acaccagaaa agctaaaaag agaacaaaga 1635661 aataacaaac ttcactaata taagaggaat acggcaatat cgtattcctc ttttgcatat 1635721 actataatca aaactcttat gtgacaaaat tcaacaagtt tctctcaaat ttaagctgaa 1635781 acagttgaga aaaagtcgtc agacatttat gatgtaaggg tacaacacat aaggaagggg 1635841 atttttatgg atacaattga aaagaaatca gttgctacca ttcgcacact gtcaatagac 1635901 gctattgaaa aagcaaattc tggtcaccca gggatgccga tgggagccgc tccaatggca 1635961 tacacgctgt ggacaaaatt tatgaacgta agtccggcaa accctggctg gtttaaccgt 1636021 gaccgttttg ttttatctgc tggacacggg tcagcactat tatacagcat gcttcattta 1636081 agcgggtttg atcttagtat tgaagatctt aagggattcc gccagtgggg cagcaaaaca 1636141 ccaggacatc cggaattcgg acatactgcc ggtgttgatg ctacaacagg tccgcttggc 1636201 caaggaattg ccatggcagt cggtatggca attgctgaac gccatttagc ggaaacatac 1636261 aaccgcgatt catttaacgt agtcgatcat tatacataca gtatttgcgg tgatggtgat 1636321 ttaatggaag gtatttcttc tgaagccgct tcactcgcag gccatcttca gcttggccgt 1636381 ctgatcgtac tatacgattc taatgacatc tctcttgatg gagacctcga ccgttcattc 1636441 tctgaaaacg tgaaacagcg ttttgaagca atgaattggg aagttcttta tgttgaggat 1636501 ggaaacaata ttgaagaatt aacagcggct atcgaaaaag cacgccaaaa tgaaaagaaa 1636561 cctacattaa ttgaagtgaa aacgacaatc ggattcggtt cacctaaccg tgccggtaca 1636621 tccggtgttc acggtgcgcc gcttggtaaa gaagaaagca aattaacaaa agaagcttac 1636681 gcgtggacat atgaagaaga cttctacgtt ccgtcagaag tttatgagca tttcgctgta 1636741 gctgttaaag aatcaggtga gaaaaaagaa caagaatgga atgctcaatt cgctaaatat 1636801 aaagaagttt atcctgaact tgctgaacag cttgaactgg caatcaaagg agagcttccg 1636861 aaggactggg atcaagaggt tcctgtgtat gaaaaaggaa gcagtttggc atcccgtgca 1636921 tcttccggtg aagttctcaa cggacttgcg aaaaaaattc ctttctttgt cggaggttct 1636981 gctgacctag cgggatcgaa caaaacgact attaaaaatg ccggtgattt tacagcggtt 1637041 gattactcag gcaaaaactt ctggtttggt gtacgtgaat ttgcgatggg tgcggcctta 1637101 aacggtatgg cgcttcatgg cggtcttcgt gtattcggcg gaactttctt tgtcttctct 1637161 gattacctgc gtcctgcgat tcgccttgca gcgttaatgg gccttcctgt gacatatgtc 1637221 ttcacacatg acagtattgc ggttggtgaa gacggtccga cgcacgagcc tgttgaacag 1637281 cttgcttcac tccgtgcgat gcctaacctt tctttgatcc gtccagcaga cggcaatgag 1637341 acagcagcag catggaagct tgcagtgcaa agcactgacc acccaacagc gctagtgctt 1637401 acacgtcaaa accttcctac catcgatcaa acatctgaag aagcattggc aggagtagaa 1637461 aaaggtgcat atgtcgtttc taaatctaaa aacgaaacac ctgacgctct tctcatcgct 1637521 tccggatcag aggtaggtct tgcaattgaa gcgcaggctg aattggcaaa agaaaatatc 1637581 gatgtttctg ttgtcagcat gccttcaatg gaccgttttg agaaacaatc tgatgaatac 1637641 aaaaacgaag tccttcctgc agatgtgaaa aaacgtcttg caattgaaat gggctcatca 1637701 tttggatggg gcaaatacac ggggcttgaa ggtgacgttc tcggcataga ccgattcggt 1637761 gcatctgctc ctggtgaaac catcattaac gaatacggct tctcagttcc gaacgtagtg 1637821 aatcgagtta aggcattaat caataagtaa gcttttgaaa gaggatgagt caaatcatcc 1637881 tctttttctt gtttatccga caaaaatagt attggctgtt taacagtaat agacaattct 1637941 ttcttttctt cttttgtata atagagagca aatgaaatgc tgctggaaaa ggggatgaaa 1638001 agatggaacg tcactactat acgtacctga tcaaagagga atttgccaat cactatttcg 1638061 gccgggaatc ggttatgttt gagctgtttc aagactatca ttggacaagc cttgaaaagc 1638121 agcagtatga aatgacagag aaacagattc aatatattac acaaccaatc ccgattttac 1638181 atatgcatca gcggttaaaa atgaatttaa acaagacgga ttacaggcag ctggattata 1638241 tttatagaat agctttgccg aaagcaaaag gccacgcgac gtttatgatg aaggagcaca 1638301 tgatagaaat tgtggcttcg ggagattacg aggcagaaac gatattcttt gaagtgttaa 1638361 gaaaagtaag cccttgcttt ttagcaatgg atttcaattc gaagcgttac ggatggctaa 1638421 atccggtgaa agaaagaaat tttgtctaaa accgaagaaa aagagatgta aatgttgtat 1638481 aatagctttt ggtttagtac actttaaact agacaacatg aaggaggaaa taaaatgact 1638541 ttatgggttg gcatcctagt gggcgttgtt gcattgctca taggtgttgc actcgggttt 1638601 tttattgctc gtaaatatat gatgagctac ctgaaaaaga atccgcctat taatgaacaa 1638661 atgttacgca tgatgatgat gcaaatggga atgaaacctt ctcaaaagaa aatcaatcaa 1638721 atgatgaaag ccatgaataa tcaaacgaaa taatacgtaa agattatgat atagagaaac 1638781 atggttataa aataaaaaac ccttatacgg gttttttatt ttgcaatcat tcatcacccg 1638841 ctactgctcg aaggcgctgc ttttgatatt gtatgagaag atggtcaagc tcctgactga 1638901 gctctatcgt aatatgagat gtcattccgt tcgccatgac aatttgcagc agctctgctc 1638961 tttttttttc aatttctttt aatagatgct ctctaatcac agggatgtat cctttcatac 1639021 attagatctt caaagtgaat gtttatatta tatccatatt tatactaatt ttcaaatgag 1639081 aaggagtata atgtctcaat gtcaaattaa attatataag ttttttctga aaatagaaat 1639141 ccttcaagtg aaagtgttaa aaaaatgaaa tgattttgtc ataacttgaa ggaatgtcaa 1639201 atcatgaagg gatgatgaca tgggagacgt gaattatttt ttgacattcg gagcggggtt 1639261 tttatccttt atttcgcctt gctgcctgcc gctttaccca gcttttttgt catatattac 1639321 aggggtcagc atggacgatg taaaaactga aaagctgctg ctgcagaaaa gaagcttgtt 1639381 tcatactttg tgttttttgc ttggcttttc agtcattttt attgctttag gctatggaac 1639441 atcttttatt ggcagcctgt ttagggatta tcacgatgcg attcggcaaa ttggcgcgtt 1639501 gcttattatt ttgttcggtt tcattacact cggtgtgttc cggcctgagg ctatgatgaa 1639561 agagcggaga atccatttta agcataaacc aagcgggttt ttagggtcgg tcttaatcgg 1639621 aatggcattt gcagctggat ggacaccatg taccggtccg atattagctg ctgttatcac 1639681 acttgcaggc accaatccgg gctcagcggt gccatacatg atgttatatg tactcggttt 1639741 tgcggtaccg tttcttttat tgtctttttt tatcacaaag ctgaagtgga taaggaagaa 1639801 ccagcttttc attatgaaag ctggtggcgt tttgatgatt gtgattggtg tgctgttatt 1639861 ctttaattgg atgagcctga tcattatttt gctgtcagat ctttttggag gctttactgg 1639921 tttttgacgg taaattactt tcgtactact actaatcctt ttgtttttgg tacaataaga 1639981 ctattatctg tggaaatcga ttgttggagg ggaatatgac aagagtttta gttgtagacg 1640041 acgccaagtt catgagagtg aaaatcagag agatcttgga agaggcaaat tacataatcg 1640101 caggcgaagc ggcggacggt gaacaagcag ctgacctgta taaaaaactg cgcccggacc 1640161 ttgtgacaat ggatattaca atgccggtga aaaacggcat aaaagcgctt cgtgatatct 1640221 taacctttga tcctaaagcg aaggtcatca tgtgcaccgc catgcgccag caaagaattg 1640281 taacggaagc aattgagctg ggggcaaagg attttattgt taagccgttt gaggaaacaa 1640341 aagtgctgga agctgtaagc cgcgttatgg gacattaaag tcatttcttt tcaaaatggt 1640401 tttttttatt gttttggagt atagtatata gtatcaacac tccgagaaac aaaggaatga 1640461 taagtatgat gattatagtt tcatcaatta ttgctgtgtt aatggctgta gctgtgatgg 1640521 tggtcagaat aaagtcctct gacaagcctg tttcaccaaa aaaaatcatt cttccgccga 1640581 tttttatgag tacgggagcg ttaatgtttt tatttccggt attttgggta actggagcag 1640641 agtttttgga agcattcact ttaggtgtga ttttctctat ttttctaatc aaaacttcta 1640701 agttcgaaat taaaaataat gaaatttaca tgaaacgctc taaagcattt gtttttatat 1640761 tagtcggtct tttggtgatc agaatcgtga tgaaatcgat cttgagcaca tcaattgatt 1640821 atggtgcact gagcggaatg ttttggattc tggctttcgg tatgattgtg ccttggagaa 1640881 tcgccatgta tttatcatat cgaaaacttc ataacgagct gcagtcatct aatattcaaa 1640941 tgaattaaaa aacctttcct cttgtcagga aaggtttttt atttgagaag ggtctgataa 1641001 ggttccaaat cgattttttt gtcccgcaga tgccttttta agaaggtatg gtctctttta 1641061 ggagttgcga gaatatagcc tttgatcata agttgctgat caatctttgc taccttttct 1641121 tttaatgcaa gctcaccgat tttgcctgcg attttagctt ttgctgcatc tctgaacagc 1641181 tctggcacgg gcgcagtcaa ttcatctaga aactgtttgt tttcatcgtt ccataaatgt 1641241 ctgctgtttt caatatagta atcctgccaa tcaagctctg atctgccgtc ctcttttggt 1641301 aaacgcttta aaaactttcg aaacatgaaa aaaccgccga ttgataataa gactaccatc 1641361 atgattaccc aaaacagaat aaaccataaa aaccatcctt ccagcatcaa tcattccccc 1641421 ttattctaac catattgtat acgaagagag attagaagaa cacagtaaaa aaagaataga 1641481 aaaaagtgat agacgtctag tcaaaagaga tagtagatca tattctattg tatagtgaat 1641541 ctgctatttg gccatgggag agtcactaga gggtatttga cgataaatgg acggaaaaaa 1641601 agtcactttc ataatagggg atgaaagtga ctttttatgt ttagctgaga ggaaattgaa 1641661 gagaaaaaga agagccatct tctgtttctt tattgacggc gactgtgagt atttgatttt 1641721 cgcattcgac ttgaatgttt ttgtcattaa aataaaaagg aagcatcatt tgtttttcaa 1641781 aagtctgtcc tgacgatttg acagttaaga tgaactcgca tccagaaagg gtaactgtta 1641841 cttgtgtagg ctgtaaaaaa gtcagatccg cttctataat atactgctga cttgtttcat 1641901 ataaatcaat aggcaatgtt tcgtcgtacc aggcgaaggg gtcttcaaaa aattgccgaa 1641961 gccattcatc catactatcg aaatcattcg catcgttgcg ttttgaatgg ttcatggaag 1642021 cattcctcca catatcaacc ttgctttaca tcatatgcgg tggattataa atgggtgaac 1642081 gcataaaaaa acagacacta aggtctgctt ttcttacata tcatggcttg agttgtgctt 1642141 ttgtcttgta tggtttcggt tttttacttt tttgcttccg cttagaggct cgggttggcc 1642201 gggattgtgt cctttagggg cgtttttatg catatcttta cttgtattct tattggtcat 1642261 aaaatgagaa cctccttaaa agagttcggt gttattgatt ggtttttctt tttttgttat 1642321 tttggcgttc tgcttcagtc agtacaagct ggtcgttttc aatatagccg gcgcctttgc 1642381 cttggctttt tgcgtcattc attccgttaa tgacgtgatt cgcttttctt ttgaccatca 1642441 ttatcacctc aatcataata tggcttcttt tattgtgtta tatgagagag cgtaaacagt 1642501 aaaaattacc ggtacatttt tctcataagt cgaacttatt gtatttaata aaaacattga 1642561 tatttactta tgtatgattt tgttttaata tgaaattgtg agaaaattgt gatggaatgt 1642621 aatgttcatc tgagaatgat ctgatctgaa gggggatttt ggagaatggc aaacgagcaa 1642681 aaaactgcag caaaagacgt tttccaagcg agaaaaacgt ttactacaaa tgggaaaaca 1642741 tatcattact actctttaaa agcgttagaa gattcaggta taggaaaggt ttcgaagctt 1642801 ccttattcca tcaaagttct tttagaatca gtattgcgtc aagttgacgg cttcgttatc 1642861 aaaaaagaac acgtggaaaa tttggcaaaa tggggaactg ccgaattaaa ggatatcgac 1642921 gttccgttca aaccgtctcg tgttatttta caagacttca caggggttcc ggcagtagta 1642981 gatctggctt cactgcgtaa agcaatggca gctgtcggcg gagatcctga taaaatcaac 1643041 cctgaaattc ctgttgatct cgttatcgat cactctgtac aggtagataa agcgggtaca 1643101 gaagatgcat tagcagtaaa tatggacttg gaattcgaaa gaaatgcaga gcgctacaaa 1643161 tttttaagct gggcaaagaa agcgtttaac aattatcagg cagtaccgcc tgcaacaggt 1643221 attgtgcacc aggtcaacct tgagttcttg gcaagtgttg tccatgccat tgaagaagac 1643281 ggcgagcttg taacgtatcc tgatacgctt gtcggaacag actcacacac aacaatgatt 1643341 aacggtatcg gtgttctcgg ctggggtgtc ggtggaattg aagctgaagc gggaatgctt 1643401 ggacagcctt cttacttccc agttccagag gtaatcggcg cgaaacttgt cggcaagctt 1643461 ccaaacggaa caacagctac tgacttggcg ttaaaagtaa cacaagtgct gcgtgaaaaa 1643521 ggcgttgtcg gtaaatttgt tgaattcttc ggaccgggaa ttgctgaact gccgcttgca 1643581 gatcgcgcaa caattgcgaa tatggctccg gaatacggtg ctacatgcgg attcttccca 1643641 gtagatgaag aagcgcttaa ctacctgcgc ctgactggcc gtgatcctga acatattgat 1643701 gttgttgaag catactgcag aagcaatggc ttgttctaca ctccagatgc ggaagaccct 1643761 caatttactg atgtggttga aattgacctg tctcaaattg aagcaaactt atcgggtcca 1643821 aagcgtcctc aggatttgat cccgctatct gctatgcagg aaacgtttaa aaagcaatta 1643881 gtcagccctg caggtaacca aggattcggt ttaaatgctg aggaagaaaa taaagaaatt 1643941 aagtttaaac tccttaacgg cgaagaaaca gttatgaaaa cgggtgcgat cgccattgct 1644001 gcgattacaa gctgtacaaa tacatcaaac ccatacgtgc tgatcggcgc cggactggta 1644061 gcgaaaaaag cggttgagtt agggcttaag gtgcctaatt acgtgaaaac gtcacttgca 1644121 ccgggttcta aagttgttac aggatatctt gtgaattcag gccttcttcc atacatgaaa 1644181 gagcttggct ttaacctcgt tgggtacggc tgtacaacat gtatcgggaa ctcaggtccg 1644241 ctttcaccgg aaatcgaaga agcggttgcg aaaaatgatc ttctgattac gtctgtcctt 1644301 tccggaaacc gtaactttga aggacgtatt cacccgcttg ttaaaggcaa ctatcttgct 1644361 tcaccgccgc ttgttgtggc atatgcgctg gctggaacgg taaacattaa cttaaaaacc 1644421 gatccaatcg gtgtgggcaa ggatggtcaa aacgtatact ttaatgatat ttggccgtca 1644481 atggacgaaa tcaatgcact tgttaagcaa actgttacgc cagagctatt ccgcaaagag 1644541 tatgaaacag tatttgatga caacaagcgc tggaacgaaa ttgaaacaac agatgaagct 1644601 ttatataaat gggataacga ttcaacttac atccaaaacc caccattctt tgaagagatg 1644661 tctgttgagc caggcaaggt tgagccatta aaaggactgc gtgttgtcgg taaattcggc 1644721 gattcagtca caactgacca tatttctcct gcgggggcaa tcggaaaaga tacgcctgcc 1644781 ggaaagtatt tgcaagaaaa aggtgtttca cctcgtgact ttaactccta cggctcccgc 1644841 cgtggaaacc atgaagtcat gatgagagga acatttgcca acattcgcat caaaaaccaa 1644901 atcgcaccgg gtacagaagg cggatttacg acgtactggc cgactggtga agtaacatcc 1644961 atctatgatg catgcatgaa atacaaagaa gataaaaccg gtcttgtcgt attagcagga 1645021 aaagactatg gtatgggatc ttcacgtgac tgggctgcaa aaggaacaaa ccttctcggc 1645081 atcagaacgg tcattgcaga gagcttcgaa agaattcaca gaagcaatct tgtattcatg 1645141 ggtgtgctgc cgcttcagtt taaacaaggt gaaaatgcgg atacactcgg cttaacgggt 1645201 aaagaagtca tcgaggtaga tgttgatgaa acagttcgtc ctcgtgacct tgtgactgta 1645261 agagcaatca atgaagacgg caatgtaaca acttttgaag cagtcgtccg ctttgatagt 1645321 gaagttgaaa ttgattacta ccgccatggc ggcatccttc aaatggtgct tcgtgaaaaa 1645381 atgaagcagt cctgatgaat caataggaag agaaggcatt tcgctttctc ttctttttat 1645441 gacacaatgt gctgcggagg tggcatatgc tgaaaaaatg gctcgcaggg atcctgctta 1645501 tcatgctagt cggttatacg ggatggaatt tatatcaaac atacagcaaa aaagaagtcg 1645561 gaattcaaga ggggcaacaa gcacctgatt tttctttgaa aacgctatca ggagagaaaa 1645621 gctctttaca ggatgcaaaa ggcaaaaaag tgctgctcaa tttttgggca acttggtgta 1645681 agccgtgccg tcaggaaatg cctgcgatgg aaaagctgca aaaagagtac gccgacaaac 1645741 ttgcggttgt tgcggtaaat ttcacttcag ctgagaaaag tgagaaacag gtccgagcgt 1645801 ttgctgatac ttatgactta acgttcccca ttctgattga taaaaaaggg atcaatgctg 1645861 actataacgt gatgtcatat ccaacgacat atatcttaga tgaaaaaggt gttatccaag 1645921 acatacatgt tggcaccatg acaaaaaaag aaatggaaca aaaactggat cttgattaga 1645981 ttcagttttt tttatactca aatatgctta caagttttca gaattggaaa aaataaaaga 1646041 atatgcggag gtgagaagcg tgaagaagat gagaaaacgt tcttttcatg agctcgtcat 1646101 ggaaaacaaa aaagagctga tgaccaatac agagtattta aatcagcttg aggaaaagct 1646161 tgaacagcga tttaagcaaa aataaccttt aatttgtatt catgtttacc cctccttttg 1646221 agaaacctat ctgttgagga gggataaaca tgggaaacaa caagaaaaac ggtcagcctc 1646281 aatatgctcc aagccacttg ggtacaaagc ctgtaaaata taaagccaat aaaggggaaa 1646341 aaatgcatga tacttcagga cagcggccga ttatcatgca gacaaaaggc gagtagcgaa 1646401 aattcgagtt tatttctagg aggtacatcc gaatgacaaa gaaccaaaat caatatcagc 1646461 agcctaatcc tgatgatcgt tctgacaatg tggaaaaatt gcaggatatg gttcaaaata 1646521 caattgaaaa tatagaagaa gcagaagcat caatggagtt tgcttcagga gaagataaac 1646581 agcgtatcaa agaaaaaaat gcaaggcgcg aacagagcat tgaagcgttt cgtaatgaaa 1646641 tacaggacga atctgcagcg agacaaaacg gataccgttc ttaaaaaacc agggaaacct 1646701 ggtttttttc tttctgattt gattatggta aaatggggct aaattgacgt taagggagca 1646761 gagtaatctt gcatgtatca aaaaaagaaa tagaagtgcg ttatgcagaa acagatcaaa 1646821 tggggattgt ctatcacgca aattatcttg tgtggatgga ggtcggcaga acggccttga 1646881 ttaaggactt aggcttttta tatagtgata tggaaaaaaa aggcgttctg tccccagtcg 1646941 ttgatatcaa tatttcctat aaaaagccgc ttcattacgg agaaaccgcg gttgtacata 1647001 catggataga ggactataac ggatttaaaa ccgtctatgg ttaccacatt tataatccgg 1647061 ccggtgagct ttccatcaaa gccacctcat ctcatatttg tgtggataaa gaaagcttta 1647121 agccaattca attccgcaaa gcttttcctg attggcacac agcatatgaa aaggccaaaa 1647181 aatagggaag tgaacgggat atggcgtttg gtgtgaaacg ggaggaactt aaccggtgga 1647241 aacaagcagt gaaaagagga gaaatcgcat ttttaacaca ttactggctg gatgaccgat 1647301 ttccagaagc aaagaccgtg acaaaagccg gctgtgcaga cattgataag ctggttcagt 1647361 ggggagcggc gtacgggtta aaaaaagaat ggatccataa gaaaagtgaa tttccccact 1647421 ttgatctgct gggggaaaca caaaaatata ttttggaaca agaaaaccta accgatcatc 1647481 ttatacgatt tcatttgtaa aaaaagaacg cacatgaagt gcgttctttt ttattggtat 1647541 tcaaaaaccg gttcatcagc gtcttctgaa tagctgacga gaaggtcgtg gttatcaaag 1647601 taccataaat cactttcttc aataaagaag gtaatgccat cagcttctgc agtgactcca 1647661 gcctcttgtg gggcatcttt cgctacaccg agagaaaaac ccttttgaac gttgctgcag 1647721 cctccatagc ggacgaaaaa gcgaacctgg tctccgcttt ccaaatcgag ttcttcttta 1647781 taccagttca atgcgtcttc gttaattgtc atattcataa cagaacaccc ctttgttctt 1647841 catttgaatt ttctctatta taaacgtatt aggctattct gtgtcaaaag agaagttttt 1647901 taagcttata accattttac tttaggttct gttttattga taattcgttt aatgttcgct 1647961 cggtgtctgt atatcacaaa aatagtgagc agggtaacga caatcaataa atacgtatca 1648021 tggacaaaga aactatatat aacagtatag atccctgtta acatcgatga gagagaaaca 1648081 aatttagtca agtataaaaa gatgaagaat accgcaacca tcgtgataaa taacaggggt 1648141 gcgtaaaata gcaaaacgcc tcctgatgtc gccacggctt taccgccttt aaatttggcg 1648201 aagatgggaa acacgtggcc taaaaccgca aagactcctg caagaagcgg gtgaatatca 1648261 acatgcatga gaaaaggcaa tgcagttgcc agtgtccctt tcaaaatatc tccggctatg 1648321 acgaccgaac cagcttttac acccaatgta cggaatgcat tggtagcgcc taagttgccg 1648381 cttccgtgct cccgaatatc aattcctttg gcaagcttgc ccacaattaa gccagatgga 1648441 atgctgccta tcaagtaggc caaaataatc aataaagcaa ttaacatcta catttctcct 1648501 ttttcaaatt cccttctttt tattttaaca tgagatgtca tgatctgatg ataagttttt 1648561 ttgtaaagtt tgcttacaaa tcaaatcaaa catgcatcat attttgattt ctcctgtttt 1648621 gatcgtgtaa aataagtgaa aaaggagtga cacacgatgc aaaacccttc taaagcggaa 1648681 attaaagaga ttcttcaaag aagcaaacgt atagcggtag tagggctttc agaccgtccg 1648741 gatagaacgt cacatatggt ttcaaaagca atgcaggacg cgggttatga aattatccct 1648801 gtgaacccta caattgatga ggcgctaggt gtcaaagccg tttcatcttt aaaagagata 1648861 gacggtccga ttgacatcgt aaatgtattc cggcgctcag aacagcttcc tggagtggcg 1648921 gaagagtttt tagagacaga tgcgccagta ttttgggcac agcaagggct agttaatgag 1648981 gaagcatacc agatgctaaa agaaaaaggc agaacggtta tcatggatct gtgcataaaa 1649041 gtggcacacg ctgtaacaaa ataggtgcag aactgcaaaa atccttgtaa attcaaggat 1649101 ttttgctttt taattttaag atattgtttg cgtattacgg tgaaacagat acaataaagc 1649161 ttgaacagct ttttttgaat accttgtcca gctgggtttc ggccgttcga tttgcgaagg 1649221 tctgctgctt tatatataat aaacaaacat acgttctcat agtgtaaaaa cagcactagc 1649281 cgatgttttg agaagaactg attcgttagc tctatgttgc gattgcaaac atattggtta 1649341 taatgaggag tccaaggcag tactggctcg aggcgaggtt tataaaaaat atcttatata 1649401 caaatgatgt gtaacactga aaagagaaag acaatgttag tttttgaaag gggtttgtac 1649461 gtttggctag aaaacagcaa tttgattaca acgaagatgc catacaggtg ctcgaaggcc 1649521 ttgaggctgt caggaaaagg ccgggtatgt atattggctc tactgacgcg cggggtttgc 1649581 accacttggt ttatgaaatt gtagataact ctgtcgacga ggtgcttgcc ggccatggag 1649641 atcacataat cgtcaaaata cataaagaca atagtatttc tgtacaggat agaggccgcg 1649701 gcatgccgac cggaatgcat aagctcggca aaccaacccc tgaagtgatt ttaacggtgc 1649761 ttcatgccgg agggaaattc ggccaaggcg gctataagac aagcggcggg ctccacggag 1649821 ttggtgcatc agtcgtgaat gctttatctg aatggctgac ggttaccatt gagcgggacg 1649881 gttttgtcta tcagcagcga tttgaaaatg gaggaaaacc ggttacatct ctcgaaaaga 1649941 tcggcaaaac aaaaaagacg ggaactctta cacactttaa gccagatcca acgatgttca 1650001 gcacaaccac ttataatttt gaaacgctct ctgagcgctt aagagagtct gcgtttttgt 1650061 taaaaggact gaaaattgag ctgattgatg aacgcaatga ccagcgtgag gtcttttatt 1650121 atgaaaacgg catagaagcg tttgttgctt acttaaatga agaaaaagac gtcttgtctg 1650181 aagtggtctc gtttgagggt gagcatcatt ctatagaagt ggactttgcg ttccagttta 1650241 acgatggtta ttctgaaaat attttgtcgt ttgtcaacaa tgtcagaaca aaagacggcg 1650301 ggacgcatga gtcaggtgca aaaactgcga tgacgcgtgc ttttaatgaa tatgcgcgaa 1650361 aagtggcttt gctgaaagaa aaggataaga accttgaagg caccgatata agggaagggc 1650421 tttcagccat tatttctgtc cgcattcctg aggagcttct tcaatttgag ggacaaacaa 1650481 aaggaaagct cggtaccagt gaagcaagat cagcggtgga tgcgattgtt tcagagcagc 1650541 ttgcttactt tttagaggaa aatcgggaca ccgcaacgct tcttgtcaaa aaagcaatca 1650601 aggcgagcca ggcgcgcgaa gcggcacgca aagcccgtga agaagcaaga agcggcaaaa 1650661 aacgaaaaaa atcagaagcg actttaagcg gaaagctgac gcctgcgggt tcaagaaacc 1650721 cggcaaaaaa tgaattgtat ctcgttgagg gagattcagc aggcgggtca gccaagcagg 1650781 gacgagaccg cagattccag gcggttctgc ctttacgcgg taaagtcatt aatacagaaa 1650841 aagctaagct tgctgatatc tttaaaaatg aagagatcaa tacgatcatt catgcgatcg 1650901 gcgggggagt cggggcagat ttctcaatcg atgacatcaa ctacgacaaa atcatcatta 1650961 tgaccgatgc cgatactgac ggcgcccata ttcaagtgct gcttcttacc tttttctatc 1651021 gctatatgaa accgctcatt gagcatggca aggtgttcat tgcgctgcca cctttatata 1651081 aggtcagtaa aggaagcggg aaaaaggaaa tcattgaata tgcatggtct gatgaagaga 1651141 tgggggatgt cctgaaaaaa gtcggcaaag gctataccat tcaacgatat aagggtcttg 1651201 gagagatgaa cgcagaccag ctgtgggaaa cgacgatgaa tccggagtcc cgcacacttg 1651261 ttagggtcaa aattgacgat gcggcacgtg tagagagacg tgtgacgacg ttaatgggag 1651321 acaaagtaga gccgcgcaga aagtggattg agaaaaacgt cgctttcggc ttagatgaag 1651381 aaagcaatat tttagaaaat gaaaacttat cggtcgctga ggaggtttaa tgattgtcac 1651441 agccagaatt atttcatgat ttaccattag aagaggtgat cggcgaccgt tttggacgct 1651501 acagtaaata tattattcaa gacagggcgc tgcccgatgc gagagacgga ttaaagccgg 1651561 tacagcgcag aattctgtat gcaatgcata cagatggaaa cacgtttgat aaaaacttca 1651621 gaaaagcggc caaaacggtc ggtaacgtca tcggtaacta tcatccgcac ggtgacagct 1651681 cggtttatga agcaatggtg cggatgagcc aggattggaa agttcgtaat gtgttaatcg 1651741 aaatgcatgg aaacaatgga agcatcgacg gagatccccc ggcagccatg cgttatacag 1651801 aggcacgatt atctccgata gcatctgagc ttcttcggga tattgacaaa aacacggttg 1651861 aatttgtgcc gaacttcgat gatacaagca aggagcctgt cgtactcccg gcgatgtttc 1651921 ctaacctatt ggtcaacgga tctaccggga tttcagcagg atacgcgacc gacattcccc 1651981 ctcatcatct gggagaagtc attgatgctg tcattaagcg tattcaaatg ccttcttgct 1652041 ctgttgacga actcatggaa gttattaaag ggcctgattt tccgacaggc ggtattattc 1652101 agggcgttga cgggataaga aaagcttacg aaaccggaaa aggaaaaatc attatccgcg 1652161 gaaaggctga aattgaaaca atcagaggcg gacgagaaca aattgtcatt actgaaattc 1652221 catttgaagt aaataaagca aaccttgtaa aaaaaatgga cgagttccgt attgataaaa 1652281 aggttgaagg catctcagag gttcgtgatg aaacggatcg aacagggctg agagtggtca 1652341 ttgaactgaa aaaagaagct gatgccaaag gcattttgaa tttcttatat aaaaatactg 1652401 atttgcagat cacatataac ttcaatatgg tggctatcca taaccgccgt ccgatgctga 1652461 tgagcctgcc gtctattttg gatgcatata tcggacacca aaaggaagtt gtcacaaacc 1652521 ggtccgttta cgagcttcaa aaagcaaaag acagacatca tatcgtagaa gggctcatga 1652581 aagctttgtc tattttggat gaagtgattg caacaatccg ttcttctagc gataaacgtg 1652641 acgctaaaaa caatttgatc gcgaaatatg aatttacaga gcctcaggct gaagccatcg 1652701 tgtcattgca gctatatcgt ttaaccaata ccgatatcac agcgcttaag gaagaggcag 1652761 aagagctcgg taaaaaaatt gaagagctcg aatctattct gagcaatgat aaaaaactgc 1652821 taaaagtgat tacaaacagc ttaaaagcac tgaaaaagaa atatgcagat acgagacgct 1652881 ccgtgattga agaaaaaatt gaagaaatta aaatcaatct cgaagtcatg gttgcatctg 1652941 aggatgtata tgtaaccgtt acgaaggatg gttacctaaa acggacgagc cagcgctcat 1653001 ttgccgcttc caacggtcag gacttcggaa tgaaagatac ggacaggatg ctgcatcagt 1653061 ttgaaatgaa tacgacagac gtgctgctgc tctttacgaa caaaggaagc tacatctatt 1653121 gtcctgttca ccagctgcct gatatcagat ggaaggacat gggccagcat ttttcaaatc 1653181 taatcactat tgaccgtgat gaaacgattg taaaggctat accgataaaa gaatttgatc 1653241 cgtcggcata tcttctattc tttacgaaaa acggtatggt gaaaaagaca gagctcactc 1653301 attataaagc acagcgttat tctaaggcac ttgtagcctt aaatctgaag ggtgaagatg 1653361 aactgattga tgtacatgta acaaatgggg aaagccagat ctttatggcc actcacttag 1653421 ggtatggtct atggtttgga gaagacgaag tgaatgtagt tggcgcgcgt gcggcaggtg 1653481 tcaaagggat taacttaaaa gaggatgact ttgttgtctc cggtgagatt cttcagcaat 1653541 ctgattcaat tgtcttgttc acacagcggg gagcggttaa acgcatgagt ctttctgagt 1653601 tcgagaagac atcccgtgca aaacgcggtg tcgtaatgct aagggaactg aaaaagaatc 1653661 ctcaccgtgt tgtagcactg ttcgcttgcg gtcttgaaca gcgactaatg gcagaaacag 1653721 aaaaaggcga cagaaaagaa ctgcagacaa aagagttgcg gacaaacgac agatacagca 1653781 atggctcttt cttttttgat gaagaggaat caggcaaggt tacagctgtt tggcgccttc 1653841 atacagaaca ataataaaaa acccgctcat actatatgag cgggtttcgt ttgtttttta 1653901 tcagctttca tggttggtga atagatctgt tacagcatga atgacttcaa tcccctgcca 1653961 tacaaataaa ttcagcgctg tgaaagaaaa taagcctaaa atcaccattc ttaagataaa 1654021 caacatgttt aacagcctcc tcatattttc gttacataat cgggtgatgt tgaacatgaa 1654081 gtttgccgaa ataagacgat tgataaaatt tggccagtat aaagcttttt ttccgctgac 1654141 gtctgcggga gtatcccgta cttttgcttt cagcggtcag cagcagaaca gccattgccc 1654201 ataaagcggt cagcgtaaat gcccctgtga tggatttctt ctcatcatca gcattttggc 1654261 cggctttcat ctcatgcatt tcctgctggt cggctacggc tttataatga tggccgatat 1654321 caaaggcgtg gggaattgag aacaaatgaa aactggcaat cgccaagaat aagatggatg 1654381 ctttcaatat cgttactttt ttcaaatgat ctccccctcc tttaatatta ctgaatattt 1654441 ttataataat accccaatcc atcctaaaag taaacctgat ttattaaatt taaaaataaa 1654501 tttaactttg ttaagtatat atctttttgc ttatttttga aagagaaaac ttcttttatt 1654561 agcgtatgta tacccggttt atggtgtgaa taaaaacata ttttaaatga tatgttgttt 1654621 aggatttatt actttattta tgtgtaaatc aaagagaaag gcaagagaat gggaagaaat 1654681 gattacattg ttaatagggt actctttttt taaagccagt ttgcaaggaa tgtttttatt 1654741 cgtaggaaaa taatagagaa ggggtcgaca gagtaacatc tggctatgac aatattcttc 1654801 tcgaaaaaac ttcctaattc gtcatattgt gatataataa aactcgttat gttaaaaaat 1654861 ctaacatcaa aatcgaattc gtattgaatt gatgaaaacg ggaggtaaat atggagtctt 1654921 ttttcaatag tttgattaat attccaagtg atttcatctg gaaataccta ttttatattt 1654981 taatagggct tggattattt tttaccatac gttttggttt tatccaattc cgttatttta 1655041 ttgaaatgtt cagaatagta ggggagaagc cggaaggaaa taaaggtgtt tcatctatgc 1655101 aggcattctt tatttcggcc gcatcccgag tcggcacagg gaatttgact ggtgtagcct 1655161 tagcaattgc gacaggcgga ccaggcgctg tattttggat gtgggtagtg gctgcagtag 1655221 gcatggcttc aagctttgtc gaaagtacat tagcacagct ttataaggta agagacgggg 1655281 aggatttccg cggagggccg gcctactata ttcaaaaggg tcttggtgcc agatggcttg 1655341 gcatcgtttt tgcaatctta attaccgtct cattcggctt gatttttaac gctgttcaaa 1655401 caaatacaat tgctggagca ttggatggcg cattccatgt aaataaaata gttgtagcca 1655461 tagttctggc ggttttaact gcgtttatca ttttcggcgg tttaaaacgt gttgtcgctg 1655521 tttcacagct aattgtgccg gttatggcag gcatttatat tcttatcgct ttatttgttg 1655581 tcatcacgaa tattacggct ttccctggcg ttatcgctac aattgttaaa aatgctttag 1655641 gttttgaaca agtcgtcggc ggcggaatag gcggcatcat cgttatcggt gcgcaacgcg 1655701 gacttttttc aaacgaagca ggaatgggga gcgcaccaaa cgcggctgcg acggctcatg 1655761 tatcccatcc ggcaaagcaa ggctttattc aaacattagg cgtatttttc gatacattta 1655821 tcatatgtac gtccacagca tttattattt tgctgtacag tgtaacgcca aaaggcgacg 1655881 gcatccaagt cacacaggct gctcttaacc atcacattgg aggctgggcg ccgactttca 1655941 tcgcagtcgc aatgttcttg tttgcattca gttcagttgt cggcaactat tattatggcg 1656001 agacaaacat tgaatttatt aaaacaagca aaacatggct gaacatttac cgtatcgctg 1656061 ttattgctat ggttgtgtat ggatctttat caggcttcca aatcgtttgg gatatggcgg 1656121 acctctttat gggtatcatg gcgctgatca acttaattgt gattgcgctg ctgtcaaacg 1656181 ttgcttacaa agtgtataaa gattacgcga aacagcgtaa gcaaggactt gatcctgtgt 1656241 ttaaagcgaa aaacatccca gggctgaaaa acgctgaaac atgggaagat gagaaacaag 1656301 aagcataata taaatataaa acaaagctgc attcaatagt tgaatgcagc tttttcatta 1656361 ttggaaataa atttaatttt tcgactcgaa tgaaaaatga cgtgtaaagt cccaattcag 1656421 tccagttttc tttgttctat atgtgtcatg tgtgtcttat tcattggagg tagagcaaat 1656481 tgacaggctt ttaaacctcc ccaaaacaag aaattaggtt gatagacaat catgagaaag 1656541 atttttacaa tgagttcgtg ctcataagaa gtgtagagcc aaaatgatgc gaaggaggaa 1656601 aagatcagat atgaaacggt caatctctat ttttattacg tgtttattga ttacgttatt 1656661 gacaatgggc ggcatgatag cttcgccggc atcagcagca gggacaaaaa cgccagtagc 1656721 caagaatggc cagcttagca taaaaggtac acagctcgtt aaccgagacg gtaaagcggt 1656781 acagctgaag gggatcagtt cacacggatt gcaatggtat ggagaatatg tcaataaaga 1656841 cagcttaaaa tggctgagag atgattgggg tatcaccgtt ttccgtgcag cgatgtatac 1656901 ggcagatggc ggttatattg acaacccgtc cgtgaaaaat aaagtaaaag aagcggttga 1656961 agcggcaaaa gagcttggga tatatgtcat cattgactgg catatcttaa atgacggtaa 1657021 tccaaaccaa aataaagaga aggcaaaaga attcttcaag gaaatgtcaa gcctttacgg 1657081 aaacacgcca aacgtcattt atgaaattgc aaacgaacca aacggtgatg tgaactggaa 1657141 gcgtgatatt aaaccatatg cggaagaagt gatttcagtt atccgcaaaa atgatccaga 1657201 caacatcatc attgtcggaa ccggtacatg gagccaggat gtgaatgatg ctgccgatga 1657261 ccagctaaaa gatgcaaacg ttatgtacgc acttcatttt tatgccggca cacacggcca 1657321 atttttacgg gataaagcaa actatgcact cagcaaagga gcacctattt ttgtgacaga 1657381 gtggggaaca agcgacgcgt ctggcaatgg cggtgtattc cttgatcaat cgagggaatg 1657441 gctgaaatat ctcgacagca agaccattag ctgggtgaac tggaatcttt ctgataagca 1657501 ggaatcatcc tcagctttaa agccgggggc atctaaaaca ggcggctggc ggttgtcaga 1657561 tttatctgct tcaggaacat tcgttagaga aaacattctc ggcaccaaag attcgacgaa 1657621 ggacattcct gaaacgccat caaaagataa acccacacag gaaaatggta tttctgtaca 1657681 gtacagagca ggggatggga gtatgaacag caaccaaatc cgtccgcagc ttcaaataaa 1657741 aaataacggc aataccacgg ttgatttaaa agatgtcact gcccgttact ggtataaagc 1657801 gaaaaacaaa ggccaaaact ttgactgtga ctacgcgcag attggatgcg gcaatgtgac 1657861 acacaagttt gtgacgttgc ataaaccaaa gcaaggtgca gatacctatc tggaacttgg 1657921 atttaaaaac ggaacgttgg caccgggagc aagcacaggg aatattcagc tccgtcttca 1657981 caatgatgac tggagcaatt atgcacaaag cggcgattat tcctttttca aatcaaatac 1658041 gtttaaaaca acgaaaaaaa tcacattata tgatcaagga aaactgattt ggggaacaga 1658101 accaaattag ttaagctttt ttttggcgga catcagtaac gatgtccgtt tttatcatct 1658161 aataggaggt ttgcgttgtg gatgaaatac tgaaacagta tatggtgctg tataaaaaaa 1658221 tgagtaatat gataaatggt cccgactatc caggtaagga aaaagacatc cagcatcaaa 1658281 aagatcagat cgaagtttac gaaaaacagc tgcagcaagg attttctaca gattatgact 1658341 atgatgtgtt tgctgattct gttatcaaat gcgcatatgg cgatatgacg ctggaagatt 1658401 tagaagccgt ttattatgga ttgacaacac catttttttg atttgtcatt cagcagtaaa 1658461 atttcaattt ctgtctcact aacttaagta tactttgata ttgagacaga aatttattta 1658521 ttttgtttac ttcctagaat atatattatg taaactagaa aagatgaaga ataaagcttt 1658581 gctgttttta tgtacatcct ttcttcttcc tgtaattcag caacaaaata aaaaagcgat 1658641 ttcccaatcg gaaaatcgcc aattcagaca ctctattatt tatgtgtgtc tttgtgctct 1658701 taacgattta caacaaatgt tgtcacgctt tgagctggaa gatgagccca aaaatgattg 1658761 cctgatacag tgagattcgt tccaggttgt agattgctgc tgctgctcgt gatccatcta 1658821 gatacgtttg aagcagatcc attctgcaaa acaaagtttt ggttgactcc tgtgttgctt 1658881 ttattgatgg caacaataac gaccttgttg tcacctttat aggctgacac gtaaacgttc 1658941 gcattagggt ttttcgttgc atcaatcctt acatagccgg gacgcacaaa ctttgagaaa 1659001 tgagccatat tgtagccgcg tttgctgatc gtaccatctt ctttcatagg tccatatgat 1659061 cttcggatgt accaccatac ataagcttga aagtccccct ctaccatcgc attgtgaata 1659121 tgctgtgaaa catccaatgc ctcaggccat cgatccgccg agttggtatc actgtttgga 1659181 tagtatactt ccgtcatcca aaggtccttc cccgctcctt tttgtttgaa aagaggataa 1659241 gggaattggc tgacctgggt gccgtacagg tgagttccga gaatatccat attggcaaga 1659301 gcctgcggat cgttcaagat cgggtccgac aaattcttca agtattgaaa tgactcaggc 1659361 gcaatgacgc gggcattgat cgagccggcg ttttctctca taaagcgaag tatttcttgc 1659421 ggcgtccacc acgtccactc gtgagcgtaa tcaggctcgt tttggaccga aatcgcgtaa 1659481 agattcacac cattattctt catgaaggta acaaaatcgt taagatgctg cgcgtatgct 1659541 gcgtacttgt tgtatttcag ccgtttagcc gatgtgtcac cattccgatt aaaggtctca 1659601 accatatcac ttggaggatt ccaaggagaa gcaaaaacga ttgctccgtg tttgaccgca 1659661 ctctttgcag tctccacctc tttataccaa ttatttcgat tttcatctac atgaattctt 1659721 aagattgaaa atcctaactg gttctgtcca ttgccaaaag cagtttctct ttgagctgct 1659781 gtaagatccc cagcccaagc cggatgattc atccctccaa aaccgcgaat cacttgtttc 1659841 tctgcagata cattaactgt tacatcactt gctgccaaaa cttcagtagc gcctggccct 1659901 aacatgactg acagcatagt gaaacatact aatagtacac aaattgtttt ttttatgcgt 1659961 ggaatcattt attcctctcc ttcgtcatgt gtcttttacg gtattaaaaa atctgcatgg 1660021 catatccata atggcgggct gttccggtgc tggcccgtac ttcacccgcc tcgtttttaa 1660081 gcggtcccat tacgagtact atctttgcgt aaactgccag taatcaaaat taaacaagtt 1660141 tcctgtacct gttccggtaa atacaaagaa tactttgtgc acaccggttg ccccgcttac 1660201 cgcagtttct atttccctcc acgtttgcgc tccgcctgtt gaaggcacat tcagagttcc 1660261 aacaagctta ccgtctgcac tgtcgaggcg cacttctatt ttcccgccta aagtggatgc 1660321 tacatttgct ttaaatgacc tggcaccgcc cgctccgaag tctgcatttc ctacagcaat 1660381 ccagtctcca ttttgaatgc ttgttacatg ctgattattt actggcccgc cgggtgctgt 1660441 ggacttctct gtcaaaatgc gtccattcca agcaaacgtt tcagcttcta cccggttata 1660501 tgggtttaaa ttggaaattt gtgttacacc tgcataattt gccgctacct cttgaataga 1660561 tccatctgca ttatgcacca gcttattaat atggggagag cggtatcctt tgccggcccc 1660621 gaacagagcg gaactgacag tttgcgcatg gtacaccaca taccactcgt ttttaaaatt 1660681 gaaaacagca tgatggttgt ttccgccacc tccgaaaaat gcacccggat ttttcaggaa 1660741 gtgccctcta tatgtaaagg gacccatggg acttgaactg gtcatgtagc cgatctcacc 1660801 cgggggttta tcggccgggt gcgtgccgcc gaaattgatg caataggagt aataatatgt 1660861 tccgttatac ttgtgcaatc ccgaatcttc aaacatgaaa ggcgcatcaa ttgtagatgc 1660921 acttccaaca acactcgtca tatcaggccc caattttatg actctagccg ttttaggatt 1660981 ggcccattgt ccctgcgttg gatttgaaac gccaggaacg cctccgccgg catacaggta 1661041 accggttccg tcgtcatcta caaatactgc cggatcaaaa agccatacaa caccagacat 1661101 tcctggcgta cttggcgtta cgagcggttt tccgattggg tcggtccatg gaccaatcgg 1661161 gctgtctgcg gtgagaaccc cgatacctcc gccgctgttt gcgaaataaa ggaagaattt 1661221 atccttgcca ttaatttttt taactgcgat tgacggtgcc catgacgcac ctgcccattt 1661281 tgcaattcca cggcctccat tagctccatt ggcacctgct accggaatgg ctccgtggtc 1661341 tgtccagttc accatatccg ctgaagatat gacgaatact ctattcaaat tggcaaatga 1661401 attatcttta attgttccgt tgctattata ttcatagtca tcacttgaca tatagatgta 1661461 gactcttccg ttataggtca gcgcaaccgg atccgctccc aaatgatggt cgataagcgg 1661521 atttgaattc cctatatgtt ttgcaattgt agtactagtg gcagcatacg cagacttccc 1661581 agataagcag ctcaataata aaactagaat ccataaacat acgctacact ttttcctcat 1661641 cacttcacat cctccttttt ccttaaaatg ggggattttc ttttggaatt tgataacaac 1661701 aggtcacgaa gattgcacgc ataaagtagc cggaagctgt ttagcaatgt tcccagttgt 1661761 tctgaaagct catcttcatg tgtctccatt ctctcttttc ttcgaggaga tcgcaccact 1661821 ccttcaaaat tgttcaaaaa aacttcccca ttcctagcga ccattgtcca gaaaataaaa 1661881 agacaggatt gttcatggcc tcccactaat cacattgaac ggagattaca tcattatcca 1661941 agatatccct ttatctaaca tcctacatca ttaaaaaaat tgtgtataga aacttttgga 1662001 ggagttagtg ttcgattcta caaaggaact ggatacattt attcattgat aagatggggc 1662061 taacactccg tttatatttg tatgttttca gacacaaaaa acagccgttc aatgcggctg 1662121 tttttttcaa gagtataaga ctattgagcg gtatacccgc tttttcatgt tttgttcata 1662181 ttttattaat tgtttattca acactgtccg ctatagtaat ccatatcaac aaatatgact 1662241 gccactcgca tcttttatga agggaggttc gttacgctga aagaaaaaat aaagacatta 1662301 ggccgttttt gcaccgtagg cgtcggcaat acgctgatag attttggtgt cttctttctt 1662361 cttaccgctt gtcatgtctc ttatctgccg gcgcagatct gctcctatac tgcaggtatc 1662421 gtcaacagct atgtgtggaa ccggaattgg acgttttgtg tgaaacgtaa ggctgacggg 1662481 aaagagatcg tgcgttttct catgattaat attgccgcgt cagggatcac ctttttgctg 1662541 ctttatttgt ttcaaaattg cggctgctcg cttttggtga gtaagctcgc cgccactatc 1662601 ggcggaatga tgatgaattt tatcggaaac cgaatctggg tatttggaga ttcgctgaaa 1662661 aacatacagg atcaggagtg aagatgaatg agaaaaaaag tgagaaaagc ggttataccc 1662721 gcagcgggtt taggaacgag atttctgccg gcgacaaagg cgcagcctaa agaaatgctt 1662781 ccaatcgtcg acaaaccagc aatccaatat attgtagaag aggccgcaga gtcaggaatt 1662841 gaagatatac tgattattac agggagaaac aaacgctcga ttgaagatca ttttgatcgg 1662901 tcggcggaat tggaattcaa tctccgggaa aaaggcaaga cggagacact taaggaaatg 1662961 cagcagattg ccgatttggc caacattcat tacatccgcc agaaagaacc gctcggatta 1663021 ggccatgcgg tgctgtgtgc ggagcatttt atcggagatg agccttttgc tgttctctta 1663081 ggtgatgata ttatggtgtc tgaaacaccg gctcttcggc aattaatgga tgtatatgac 1663141 gtttatggca cagaggttgt cggtgtacag tcagttctcc ctgaggatgt cagcaaatat 1663201 ggtattataa atacatcagg gtctcaaggg catgtatatg aagtgaacga tttagtggaa 1663261 aagccttctc ctgaagaagc accttcggaa atcgcagtaa tgggacgtta tgtgctgaat 1663321 tcttcgatct tctccgtttt gaagacaatt ggcagaggcg cgggcaacga aattcagctg 1663381 acagatgcgc ttcgtgaggt ttgccgtaag gagccgatcc atgcccggct gctggaagga 1663441 aatcgatatg acattggcga taagctgggc tgttttaaag cgagcaccga aatcggctta 1663501 atgcgtcccg aaatgagatc tcagcttttg gcctatttag aagatgtgat caaacgggaa 1663561 acgaaagaaa tgctgcggta aaaaaattgt aaccatcttg ctcgtcaatc agtcatataa 1663621 tagtgaaaaa gattaggaca ggttgtgaag aatgtgggca gtttgataag cgaaatttta 1663681 acatggctga cgaacatggg atatgcgggt attgcgattg ggttaatgat tgaaatcatt 1663741 ccgagtgaga ttgtattagc ttatggcggc tatatggtat cggagggcac gattggattt 1663801 attggcgcaa ttattgcggg tgttatcggg ggcaccattg cccagatctt tatttactgg 1663861 atcggtcgct atggcggcag gccatttctg gacaaatacg ggaagtattt attgattaaa 1663921 aagcatcata tcgatatgtc ggaaaactgg tttcagaaat acggcgccgg agttgtcttc 1663981 tcggctcgtt ttataccggt tgtcagacat gccatatcca ttccggcagg tattgccaga 1664041 atgccttttc tcaaatttgt ggtactgact gtgcttgcta tcattccatg gtctatcctg 1664101 tttgtttatt taggcataca gctaggaagc cagtgggatg atgttgagaa tatagcaggc 1664161 acttatacaa caccgattat gatattggct gttgtcgtga tagcccttta ttttgtgatt 1664221 aagaaacgta cagccatatt taaacgatag ctagcggata tgcatagggg tgactgacgc 1664281 tcccctatgc atattttttt acttgcgatg ttgatttgcc agcttcagat tctccgctaa 1664341 aaatgcgaca aacacttcat cccgcacgag cgatgcggca taatttctct taataaacca 1664401 ttctgcctct tcaaacgctg cgaatgtttc gtcttgggtt tctccgttaa tttgaatatt 1664461 ccattcgttg tctaaaggga aaagaaaaaa tctcatttgt gcgcgatttt catataatga 1664521 tccattcgca gatcccttta gattatagat gttacggaag gcatccggcc gtacaggatc 1664581 aatacggaaa gcttcagcta caaacaactc gtatacttca tcggttattg aacagccgga 1664641 cgcttttgca tgccctccgc cgccatatcg gccggcgatt tctgacacat cgatgtaatc 1664701 atgaatggtg cggagactga ctcgttttga ccccatgctc aaaatcgcaa tgtaatcgag 1664761 gtgcgggtta tctttcccta gcctgttccc cagctctgaa tggtacgatt cagcgtgaac 1664821 gatgcctaca cagtgttcgt gaacaaaggt ttgtaccatt tcccttttct ttctgcggag 1664881 gtagcgctcg attttttcgt cttctaaatc aagcagtttt tcttcaaaat catcgaagaa 1664941 aaattcgtca tgcgtggaaa ggcgctggat catttttgct tcaaattcat cgattgacag 1665001 caaaaagaaa agatcattaa gccgcttcgc ctgtttttga tcgtaccgct cccactccca 1665061 tgtatcgtat tggcggacga gctctgtgaa ttgatctaag gcgtttgtcg gtttcatgaa 1665121 gccattttca atgagatagc catataaaag cgatgtcgcg gatgtgagcc ttccatcatc 1665181 gtattccacc tggacaaatc cccattcatg ctcattcaaa tgaagggctg ttttatgatg 1665241 gtcaatgagc ttcactttgc cccctgcatg aacatactca ttcaatctct cttcgttttc 1665301 ttcattgacg gcgagatcgg tgatgaataa cgcgtcctgt ctgttgctct ccttcgcttt 1665361 ttctaaaaag tactgcacct gtgcgtttaa gccgttgaca gagttatacc ggatctctac 1665421 gtcttttccg aacgccaatt ttgctacgat tccgcatcct actccgtcca agtcgttatg 1665481 tgaatataaa tgatacataa tgtaggcccc tttttatgat aaactgacaa ttgccgctag 1665541 aggtgcggca gcctttattt actattctaa aaaaccaagc gttttatgca atggtaatta 1665601 gttgacataa tgttgttatt gtaaatatat aaaggagcgc tttttttgcg ctcctaagtt 1665661 cttgctttta caccggataa accggatgct ttcgattggt aaatgtcatt tcctttgtca 1665721 tgtatgcctt gagccgtttg gccagctcat cacgcagcga attggctggg ataacagcat 1665781 caatgatcat ttctgaagcc agacggtaga tattgatgtc ctctttgtat tcctcccgtt 1665841 tgctgctgat aaatgcggct ctctcttctt ctggcagctc ggcgattttt ttagcgtaga 1665901 cagcgtttac agcggcctca gggcccatga cggcgatttg ggcggttggg agcgctagac 1665961 agcaatccgg ttcaaatgcc ggccctgcca ttgcatacaa ccccgccccg taagcttttc 1666021 ggacaatgac agagagtttt ggaacagttg cctccgacat cgcagaaatc attttcgctc 1666081 cgtgtctgat aatcccagcc tgttctactt ttgtgccaat cataaaaccg gggatatcgg 1666141 ctaagaacag caatgggata tgaaaagcgt cacataaggt aataaactta gccgctttgt 1666201 ctgctgaatc gtggaataag acgcctcctt ttaccttcgg ctggtttgca acaatgccga 1666261 caggctgtcc gtggattcgt gcgaggcccg tcaataattc cggtgcaaat aaggctttga 1666321 tctcaaaaaa tgagtcttca tctatgaccc gctcaatgag ctcatgcata tcaaaaggtg 1666381 cgttttgatt ttgcggaatg acgtcggcaa gcggagtttc gaagtgtttt ggcgggcgtt 1666441 tctcatgaat gggcgctttt tcttgaaaat ttgccggaaa gtaagacaaa taagcccgca 1666501 ccagctgtat ggcttcttct tcagtttctg caagaatatc tccgcagccg gagattgagc 1666561 aatgcatacg ggcgccaccc atttcttcga gagacacttt ttctccaata accatttccg 1666621 ccatccttgg cgaacctaaa tacatggagg cgttaccgtc taccataacg acgatatcac 1666681 agaaggccgg aatataagcg cctcctgccg cagatggtcc gaaaagcaga cagatttgcg 1666741 gaatgcgtcc cgataatttg acttgattgt aaaaaattct tcctgcaccg cgtctccctg 1666801 gaaagacatt gatttggtcg gtaattcggg cgcctgccga atcgactaaa taaatgagcg 1666861 gacagtttaa tttttcggcg atttcttgaa ttctgatgat tttttcaact gtttttgctc 1666921 cccatgaccc cgctttcact gttgaatcat tcgccatgac gcaaacggtt tggccgccga 1666981 ttttgccgat agcggttaca actccgtcag cgggaagccc gtctgacata cattccgcaa 1667041 aaaaagcgtc ttctagctca atgtcatcgt caaagagaag ggaaagccgc tctctgacaa 1667101 agagcttgcc tttttcccga ttgctttgat gatacttttc cgctccgcct tttcgaatcc 1667161 gttcagcccg ttctgttcgt tccttttcat aatccatcag cattgcctcc cttttatatt 1667221 cccttgtata cggcccgtct tttttcttga aaggcctgaa gcccttctct cctgtctttt 1667281 gtcgggatgg tttgttcata cgctttttgt tcaatcgcaa ggcctgtagc aagatctgtc 1667341 tccaatcctt tattgattgc aaatttagcc tgacggacag cgatcggtcc gttggcagaa 1667401 atggctgcgg ccagttcctc tgcttttggc ataaggtcac aaggagccgt gacatgctct 1667461 acaaggccga tttcttttgc ttcgtgtgcg gtcacgcgtc tgcctgtata aatgaattct 1667521 tttgcttttc ctctgccaat cagccggggc agcctttggg tccctccagc gcccgggata 1667581 atagctaacc ctgtttccgg aagtcccagc acagctgctt cagttgcgat tcgaaggtcg 1667641 catgccaatg ccaattctag tccgccgcct aatgcgcttc catttatcgc agctatgacc 1667701 ggctgcggca aggcatcaag taaagccgcc gttctttgaa tgagagatac actttccaga 1667761 acctgatctt ctttcagttt tatccgttcc ttcaggtctg cccctgcaca aaacgctttt 1667821 tcaccggtgc ctgtgaggat gacgcaacgg atgtttgagt taaattcaat ttcctggata 1667881 atcatttgca ggtttctaag catttccgct gaaagagcat ttgctgcctg aggcctgttt 1667941 aaggtgatca acgccatatg ttcattttta acagtaaaaa gaatagaatc tcccattgta 1668001 tgcgtcctcc cttttatcaa gatgatttaa acacctgtaa atttctgctc ggcagcggtt 1668061 tgcccatttt ttcttcaatc catttggccg cagatagcag tttttctagc tttacatttg 1668121 ttttgatatc catctgttca agcatgtaca cgatatcctc agttgcggcg tttcctgatg 1668181 aacctggcgc atatgggcat cccccaagcc cgcctgccga gccgtcgaac accgtgatgc 1668241 ccatttggag tgctgtgacc atgttggcca gagcggttcc tctcgtatca tgaaaatgca 1668301 gggcaatttg attagccggg aatcgtgcca aaagagcttc aagtacagtt tccacttggg 1668361 cgggattagc tgctccaatc gtatctccaa gcgacagttc agaaatccca aattcaaata 1668421 gagcttctga aaggcgaatg acttgttcaa tggggacatc tttttcgtac ggacagccga 1668481 aaacagtcga gaggtaggct cttgttgtga ggtttgcttt ttgtgcgtcg ttgtttactt 1668541 gtttgagtat atggagggat tcagaagtgg atttattgat gttttttctg ttgtgcgtct 1668601 cgctggcgga cataaaaacg caagcctcgt taatgcctcc ttcaagtgca ttctccagtc 1668661 ctctttgatt cgggacaagt gccgcgtacg ttaccccttt ttctcggtcg atgccttttg 1668721 ctacatcgat agcatctcga agcgccggaa tccatttcgg gtgaacgaag gatgtgattt 1668781 caatatacga cagccctgtc cgggaaagct ggttgatcca ggttatttta tcctctgttg 1668841 cgatccaaac gggctcgttt tgtaagccat cacgcgggcc gacttctttg attgtcactt 1668901 ttttaggata tggcatggtc ttcctccaaa ttattgagtg gaattgctca gttcgagcag 1668961 tacgtctcct tcatttacaa agtcgccttc cttttttttg acttctttta cgattccgct 1669021 tctatctgca acgatcggga tttccatttt catcgattcc aaaatggcta cctcctggcc 1669081 cttttcgatt tggtcgccgg ctttgacgtg gactttccac aggtttcctg ccatttgtat 1669141 gctaaccgtc atgacaactg cctcctttat aggtgctgtt tcaaaaagtc agtcgtgaca 1669201 tccccttctt taaatgcctt tgttgccgca gcctgtatga ggagcggaag gtttgttttg 1669261 attccctcta cacgatagtc gcgaagcgct gtctctagtt tttcaattgc ttctgttctg 1669321 gtttggcctt tgacaatcat cttagcgatc atcgggtcat aaaaaggggt aacggtgctg 1669381 tcttttgcta ccgcacattc gtgtctgact cctttttggt caggaagtga aaacgcagtg 1669441 atcgtacctg gtgacgggaa gaaggtcttg ggatcttccg cgtatattcg aacctctatc 1669501 gcatgcccgt tccgttggat gtctttttgg gagaatgtga gtgtatggcc cgcagcaatc 1669561 cgcagctgct gctcaactaa gtccaggcct gttatttctt cagtcacggg gtgttcaact 1669621 tgcagtctcg tattcatttc gaggaaataa aaattttgtt tctggtcaac tataaattcg 1669681 atggtgcctg cgttcgtata gccgattgcc ttcgctgctt ttaccgctgt ttgaccgatc 1669741 ttcattctta gttcatcgtc tacaaatgga gacggtgctt cttcaatgac tttttggtgg 1669801 cgcctctgaa cagagcaatc acgttcaaac agatgtactg tatggccgtg ttgatcggcc 1669861 aaaagctgaa cctcgatgtg gcgcgcatgt tcaataactt tttctatata catagacccg 1669921 tcaccgaaaa aatctgctgc gcgctttttg tttccctcgt acgctttttt taatgcttct 1669981 tcattttcaa cacgctgcat tccgatgccg cctccgcccg ctgaagcttt cagcatgaca 1670041 ggatagccga tttgacttgc ggtgcggcag gctgcctcta tatctccgag ggattcagaa 1670101 acgcccggca ccacagggac acctgcagcc tccattgctt ttcgcgcttc aattttgctg 1670161 cccatctttg cgatgatatc aggggaaggt ccgataaaca cgatgttttc ttgcttgcag 1670221 cgttcagcga accggctgtt ttctgataac aatccatatc ccgggtggat cgcgtcggct 1670281 tttgcttttt tcgccgtctt tatgattctc tctatattta aataactttc actgactctc 1670341 gattccccga tcaaatatgc ctctgtagcg gcttttgtat ggggcgcgtc cttgtctgct 1670401 tctgaataaa cagcgaccgt tttaatgccg agacggctgc atgttcggat aattctcatt 1670461 gcaatttcac cgcggttggc gatcagtact tttgtaaaca tgatttcacc tcattgactt 1670521 gatgataagt tgaacatttc aatcgttttt tctcgcagtt tatatttttg aattttgcct 1670581 gaggccgtca tcggatagtc atccgtaaaa ataacataac gcggaatttt gtggcgggcg 1670641 attttccctt tgcaataggc tttaagctca tcaggtgaaa cgcttttacc gtctttcagt 1670701 ttaatccagg ctgcagcttc ctccccgaat ttggcgtcag gcacaccaac cacctgtaca 1670761 tctaaaacag cgggatgctg gtataaaaat tcttcaattt cccgcggata aatgttctcg 1670821 ccgcctctga tgagcatatc ttttaatctt ccggtgatgc ggcagtaccc gtcttcatcc 1670881 atgacagcaa gatctccggt aaacagccat ccgtcatgat tgattgcttt tctggtcgca 1670941 tctttgtctt tataatagcc tttcatgacg tgatagccac gggtgcacag ttctccctgc 1671001 atgcctcttt gaacttcttg acatgtcccg ggttctacaa ttttcacctc agtatgtggc 1671061 agggcacggc cggttgtttc gactcttctt atgaaggaat catttgctct cgtttgtgta 1671121 atgactggcg aggcttcggt ttgtccatag gcgatcgtaa tgtctttcat gcccatcctt 1671181 tcaatcacag ctttcatcac ttcacttgga cagggagagc cggccatgat tcctgttcgg 1671241 agcgtcgata gatcatatgc atcaaaatcc ggatgatgca gctcggcgat aaacatggta 1671301 ggcacaccat ggagcactgt gcatttctct ttttctaccg ttttaaggac ggtaacggga 1671361 tcaaattctt gcacgggtat catggctgcc ccgacggata cacatgccaa aaccccaagg 1671421 acgcatccaa agcagtgaaa aaacggaaca gggatgcaca tgcggtcttg agaggttaaa 1671481 gccatacatt cagcgatatt agcagcgtta ttgatgacat tgaaatgggt cagcatcacg 1671541 ccttttggaa accctgtcgt tcctgatgtg tattgcatat taatcacatt gtctttatcc 1671601 aggctgttca ttctctcttc aagctcagca tctgtcactg ttttcgccaa tatctctgta 1671661 tcgtcccaat gatacatgcc agacaatcgt ttattgccaa tatagatcag cgtttttaaa 1671721 aagggatagc gttcagattt cagttggccg ggctttgctt cttgcagttc tggaattaaa 1671781 ctgttcacga tgtctggata agaagtgccc ctgtatgaat ccatgataat aagcgccgcg 1671841 gcatccgatt gctttaacaa gtaatcaagc tcatgtgctt gataattggt attgacggtc 1671901 acgagcacgg ctccgatctt cgcagttgcg aactggacgg caagccattc agagatatta 1671961 gaagcccata tggcgacgtg gtctcctttt ccaatcccca tccgcatgag acctttagcg 1672021 gtttgacggc acagactgtc aaattgagcg tacgtatagc ggatatttcg gtctggatac 1672081 acaacagcat ctcgatcggg atacgcatca gctgtttgtt ccagcagcct gccgattgtg 1672141 gaatggatga gttcagccat tcattgttcc tcctttctta atgataggaa agcgtttaca 1672201 tttttatttt aaaagctgtc tggcgatcac gagacgctga atttcagatg tgccttcacc 1672261 gatttccatt aattttgcgt cccgcagcat ccgttccacc ccatactctt tcatatagcc 1672321 tgaacctcca tggatttgaa tggcttgatt gcaagctctt gtcgccattt cagatgcgaa 1672381 tagcttggcg tacgccgctt ctttggtgaa cgggcggtta tgatctttca gccaggcggc 1672441 ttttaacacc atttgccgtg ccagatcaat ttccatcgcc atgtcagcaa gcttaaattg 1672501 aatcgcttga aaggaagaaa tcggctgtcc aaactgcttt cgctctttcg catatgccaa 1672561 tgatgcgtca agggccgctt gggcaatgcc gactgcaaga gcagcgatgg agattcgacc 1672621 accatccagc gtatatagaa actgtttaaa cccttttgtt ggatcgccaa gtaagttggc 1672681 cgcaggcact cttacatctt caagcaagat ttccgctgta ttcgaaccgc ggacgcccat 1672741 tttatcgtac gggctcgtaa tcgtaagtcc tggtgtgtca gttggcacga ttaatgcgga 1672801 gatgatgttt tttccgtctt tgtttttgcc tgttacggcg gttacaataa ctgtgcgtgc 1672861 gtagcttgca ttagtgatcc agcacttttc gccgttgatt acatactcgt caccatttga 1672921 aatcgctttt gtttgagtgc ctcctgcatc tgagccggca tttggctccg tcaggccgaa 1672981 tgatccgagt gctgtgcctg aagccagcgg cgtcaaatgc gtctgttttt gctcttctgt 1673041 tccgaagtag taaagagggc ttgcgcctag cgagaccgct gcagcatagc ttaatccagt 1673101 actgccgcag gctttgccga cttcttcaac cgctaaggca tatgaaatcg tatcaccgcc 1673161 agatccgccg tattcttctg gaaatggaat acccatcaga ccgagttcac ccattttttt 1673221 aaatgtttgc atcgggaact cgcctgtttg atctacatgt tcagcgtgag gagcaatttc 1673281 ttttttcgca aaatctttta ccatttcacg caccatttgt tgttcttttg tcagctcaaa 1673341 attcacatcg tttcctcctt cacatctttg taacatccta ttaggcgagt tctataatca 1673401 ttccctgaca agaaaagtct gaaaattaaa actgaatcat tttttatgtg ataatatcag 1673461 cgggatgagc aaatacatgc agtaggcgca taccatccat atcgtaaacg caataacttg 1673521 gccctttgat aaagccggga agatgagggg aagattccaa agggaaatcg tatccatcaa 1673581 taaaccgacc gctgatcccc atatacctag cttgatcacc gcgaactgtg attgatcgag 1673641 tttttgatag agaaagaaca caaggcataa aacaagagca gtgcccgctc ccaagagaag 1673701 aaagttcggc aaaaaggctt cttcagccgg atcagtcaac acagcatctc cgaacagcac 1673761 aaaaaataat gtggcaccta accagactag aaatgaaaac gtaaaacacg tcctgtacgt 1673821 gtttctcttc gattttattt ttatttagta ctagtttctc agattccaat aatggtaaat 1673881 gtccaaacac cgcctccata ttcatgtgaa tctcaccttt gttttttaaa aaattcagcg 1673941 gtttaccatc gtttcctgtc ccaaaatcac tttttaaaaa aagacgactt agaaagccgt 1674001 ccttctcatt tcttattttg ttgttcgttt ggaagctttg ctttcgttat gaagccggtc 1674061 tgctgaagtg acataatacg tatatttctt gttgggatct gccgtgttat ctaagaaggt 1674121 ttgctgctca tgtgtttttc tttgcgttgc cagcaatgtt ctctgctttt tcccttcggc 1674181 tctgtatatc gcataatagg ctgtttcttt cgttttttga tttgatgggt gatctttaat 1674241 ctgcagaaga ttgccgtttt tgtcttcggt gactttcgta agcttcggtt tttttggggc 1674301 ggtattgtca agccaaggca tttgcggaac cagtgccggc ttgctgtaaa gatcggtgct 1674361 gagactgtct ttgatgccaa gcggattttt gttgaggtcc ttgaggctga aatgcatgct 1674421 tcctttcacc agttcaagct ggcggttcaa agtgatttgc cgcacatatt cctcaggatc 1674481 ggaccaaggc ggatcaaaat tgttattgat tttatatgct gcctggccaa tatataagtg 1674541 aacaggccta tttttgactt cattgctcca ccaatcagcc agcacgtcgt aagccgctgc 1674601 gttaaagccg atactccaat aaatttgcgg agcaatataa tcgatgtcgc cttcttggat 1674661 ccaatgcctt gtgtctgcat atagatcgtc ataatttctg acgcctgctt ttgtattcga 1674721 tccggtcggg tcatctgcgg cgtttctcca tactccaaag ggactgatgc cgaatttgac 1674781 atacggtttt gcagctttaa ttgtttggtt gatttgtttg acaagctggt tcacattgtc 1674841 ccgccgccag tcatcgatat tagaaaaagc gtcttttccg tattgttcgt actgtgcttg 1674901 atcaggaaat tcctgtcccg ctattttata agggtaaaaa taatcatcca tatgaacagc 1674961 atcgatatca taatgtttta cgacttcttc aatgcctttg acgataaaat ctctcgcttc 1675021 tggaatgcct ggatgataat acagctggtt tccataggcg gcaacccaat ctggatgttt 1675081 tcttgccggg tgatcctcag acaatttatt aagatctgta tgattcattg taatacggta 1675141 aggattaaac cacgcgtgaa attccaaatt tcgtttatgg gtttcttcaa tcataaatgc 1675201 aagaggatca tagccggggt ccttcccttg gacaccggtt aagtattccg accaaggccc 1675261 gtaagctgac ggataaaagg catcagccgt cggtttaatc tgaacgataa cggcattcat 1675321 tcccattttt tgcacatcgt ccagcagttt gatatactcc tgtttttgct ctttcacaga 1675381 taaccctttt ttggacggcc aatcaatatt taatacggaa gcaatccata cggctctcag 1675441 ctccctgtca gactgcgcat tggccataaa cggaacggaa atgacaaacg ttccgatgat 1675501 caagctgaca aggaaacgga caatcgactt ttggcaaacc ttcattctgt ttcttctccc 1675561 ccattacatc actttcacta ttcgctatta cggtattccc gggctataaa agggtgatta 1675621 acagaatgtc tatctcacta aataaacgaa aaaagtccta aagcatgttg tgaaccgctt 1675681 ttaggacttt ttatcattca tcatggtttg cagacttttt aacacatcaa taagttttac 1675741 gccgacaccg acagccgttt caaggatcgc ttgtgctccg gcaatggcta aaataaagat 1675801 cagcggtatt gcaatacgag gcaaaaaaag atagccaagt ccgatcaaga tggcacacca 1675861 aacaccggca caccagtagc aattgagcat gtatccaaag ttagaagccg gcacgctttt 1675921 ttcatctaca tgcccgtttt gatcaacaat ccttttcttt ttcataaaag gttttcggat 1675981 aaattctgtg attttgtcaa atacaatcaa atgtgtcagc ctgtaactgg ctagaatcag 1676041 catgataaaa gttagaaaag aaagacggtc cattgagaag cctccaagaa aaaggatgat 1676101 gttatcattc ccaagtgtcc cttatccatt cttgatacaa aaagaaagac ggacagagaa 1676161 tggcctctgt ccgctaatcc gagctcattc cctccagttc tcataataag aggataagaa 1676221 aatgtagaaa aaagcagaaa aatgacaata aaagaaatta tatgactata taatccatat 1676281 atgcactata ttaacggata ttttttaaag tacaataaaa aacattaaat ttttataaca 1676341 ttttttttga atatagtatt atttctttat ttttcgtttc tttttttatc aaatttccgg 1676401 atataaagtg ataaaagtat tgttttacat aaggtcttat acactacttt ttaatcggac 1676461 taattttctt ttgtgcatca ttcttctaat tgttggaagg ttcgacaaag cgttattaca 1676521 gacataaaaa aacctgtttt ctcttggaaa acaggtctcc cgctattatt gatttgccaa 1676581 aatgacagcg atttgatcct caatatcttt tccatcctct tcatcaatca atccatttag 1676641 aagaatagag aaaacaagtt tttttccgct ctttgtttct gcgtaccccg atagagagct 1676701 taccgtactg agcgatccgg tttttgctct tacttttcct tgtgcaggag tgcctttcat 1676761 gcggtttctc agcgttccgc ccaccattct gtcaggattc cccgcaacag gtaaagaatt 1676821 tagataagcc gagaaccaac tctgatcctg aatgtcatat aacagctgtg aaagttgatc 1676881 tgaggataca gcatcaatat gtgagattcc tgatccgtcc cttaagacga gtgatttaga 1676941 atcaacacca aattccggaa gcgtactgtt taacacttcg agcccctttt cccagctccc 1677001 ttctcctttt ttcactttcc ccatctcttt tacgagcact tcggcatgtc cgttattact 1677061 taatttcatg aacggcacaa aaagtttcga taaaggcatt gagcgatgag agagcagcac 1677121 atctgaagaa ctaggtgctt cacccgtctt gatgtcccct ttcacagtaa taccttgttt 1677181 ttttagtgac tgcttaaata aatctaaggc atatccggca ggctcccaga cagaaatcca 1677241 ttcctttgtc ttgtttgcgt caaccggtac gctcccttca attgtaatcg tgtttgttcc 1677301 atgctctctt tcgattgtga ggtctttctc tgaaccggca gcagtcgttt tagcatcgtt 1677361 ctttatcgtt atataatcgg ttttcggaga gacagacacg gcaggctctt ccccttcttt 1677421 ttgatttggg gtgacctcaa caatcacagt gcctgcatca tagtcttcgt ttggagacgc 1677481 tgttagagcg gagattggcg cgccataata tgtgtattca tcgctccaag gcatatcagg 1677541 tgataatcgc atgtcatcat gccacgtatc atcaccgatc agattgcctt taattacttt 1677601 tacgccggaa tgtttcaata tctcagccat tttgtcaaaa tcagatggta aaagtgtcgg 1677661 atcgcctttc cctttcaaat aaaggttacc attcagcttt ttccctttca gtgttccatc 1677721 cgtccggacc tcggttgtaa aagaatagtt ctcgccaagg acagaaagtg ccgcggccgc 1677781 tgtcaaaagc tttagagaag aggcaggcct cattcgggtg tctcctgaat gttcatatag 1677841 aacagcacct gtttccgcag agcgaacggt gatgccggcc attgcgcctt cgagggcagg 1677901 atgatcagct aaaatcttat cgatctgccc ggaaagtgca tcttgttttt cagcggcaag 1677961 cgcagcctga tgcatataag gcaccgaagc aacgacgaaa agcagtaaaa cagcaacata 1678021 aagctttatg ctttttttca ttaatttccc cgcctctctg cgcttcatca ttggctattg 1678081 atgattcagt tcaatggtga tactgctttt agctgtcgtt tcttctcccg gctccagcac 1678141 ttgtaaacca gtgagtgacg aaggtaaatc aagattcact gcgtttgtca cccatgtgta 1678201 aggctcaggg cataaatacc cttgttttcc gtccgcattg tatacaaccc aatgtttaaa 1678261 ctgttcatct gccttataaa taatgctgat atgtgcatgc tgatgataaa tgactgcctg 1678321 gttttctccg cccctcttct gataagaaga taaaaagaca tcatccagct gcttgtggcg 1678381 caaatccatt ccttcatgca aagcttcttt atacgggaca tccatcagct tcccggtcgg 1678441 cagcaggcgt tcatccaact cccattgctg atctgctgtc agggagaata acgagctttc 1678501 tgccggaaat ataaatgtag tatgataacc aattccccaa ggaaacgctt cctttccttt 1678561 gttcatgacc gtcgcatgtt taaatagggt attctccttg atcgtgtatg tcatccgaac 1678621 gacggcatga tgaggaaatt gcttctgcac atggggaagc tcagaaagat caatttctgt 1678681 ttcaacaatc actccttcat cagtttgctt cgtggtcacg acattccact tttcatggta 1678741 aagaaacccg tgaagatggt tgtgtttatc cttctcgttg atatcaaaat gatacgttct 1678801 gccccggaaa ctgaatgtac cgtcacttat gcggttaggc gggaacagga ttggaatgcc 1678861 atacaatgtt ggtgtgtcgt gaaaactttc tgctgtttcc ggttcacgca aaagctggac 1678921 atttgttgtt ttgtccacga gagaaatgac gttgctcccc cactcaggga caacaatcat 1678981 ttctagatgt tcgttgcccg ctttgatggc cggcgttccc aaatacgtga ttttctcaat 1679041 aaagtttgcc atgtttactc aacctctcct tgattcattg ctagtataag aattcaatgt 1679101 actgtaccat atttcctcca ttttatattt tcccctatca aataaaaaaa caccgttcaa 1679161 acttatgaac ggtgtgattc ggaggctatt ggatgagacg tgtgatttgt ttctttttcc 1679221 agacgaattg ataataccca taaatcaaca gcaagctgac ggcaaacgca gctggataac 1679281 caacccagac gccgagtatt tcaagctttg tatagtgaga aaggacgaaa gcgacaggca 1679341 cctctactcc ccagattgca aaaatactga tgacggtcgg ccataaaact gttccgcttg 1679401 cccgcatcgt tgcagaaata atttgggcat ttccaaacag caaatagctc cacagtgtaa 1679461 tcatcaaaag acggtgcgca atgtaaagcg tctcttgctc ggttaaaaat aacgataaaa 1679521 tctgatgtga aaaaacatag atcagaatga tcagtacgcc gccaatgata taattcagcc 1679581 aaatcccaac gcgaatgacc tgctttaagc ggtcaaactc gtttgctccg atcgattgcg 1679641 cagcgaaaat agaaaccgca ataccaaggc tgacggccgg catctgtaca tagctggcca 1679701 cctggttgac cactccgtat gcagctgttg cattagagcc gtaatgattg acgaatgaaa 1679761 taaccgctat ctctgataat gagacaagaa tcatattgat gcttgctggg accccaagac 1679821 gcagcaggag aaccagcagt tccttatcca ttttcaaata acgacgcact gttttatcaa 1679881 attgcagcgg gtgttttcgc tttcgtaaat acaccattaa cacgagaaaa gtcgcaatcg 1679941 tggaaatgac agttgcatat gccgagccgt atatgcccag tttcggaaaa ccaaacatgc 1680001 caaggattaa aacaggcaaa agcgcgatgt tgatgaccgt gctcacaatc agcgtataaa 1680061 acggtgtctt ggaatctcct gttccgcgca aaaaggtagt atatgcaaaa tataaaaaca 1680121 taaacggcat agcataaaat aaaatacgtg catagttagc gctgacatga atgacatttt 1680181 caggtgttcc cattaaacga aggatatcca gggtgaaaat actgccgata acggctaaca 1680241 caacgcctaa taaaaatgta aacgtgagtg tcgtcccgac aacagccttt agccgttcct 1680301 catttttcgc tccgtaagct tgtcctatca gaatcgaact tcctgaaccg atcccaatcg 1680361 taaatgagat taaaagaaaa aataacggga aaaaggatga tacagctgcc actgcatcaa 1680421 caccgagcca tctgcctaca gccatcatcc cgactagctg gccgactgat tgcagcacat 1680481 tgctcagcag aagcggcact aaaaagagtg acatcgaccg ccaaactgat ggtttgcttt 1680541 tcttttgagt tacaagaggt tcttgtgatg tttccatatt aaaggactcc tttatttgaa 1680601 atcgttttta aacatgccct cattttttga caaaaacagg atatgtaaca tgttattatt 1680661 catcactgca cttatgaaac ccttcccgat tcttctaatt ttacacatct ttttagctta 1680721 tgaagaataa actagcaagt aatggcgtat tttttgtgag taaaagaata aaaaataatt 1680781 tatgcaaaag tattgtaatc tatccgtaat tattgtaaca tttgtaacat aagagaaaga 1680841 gattttgaag gagagagcga taatgaaaaa atgtcttcta tttctaacaa ccattgcact 1680901 tattctgtca ttaagcacaa atgcatttgc gaaaaataca tcaggcgatt tatcacaaaa 1680961 acaagcatta cagttggcat tatccgctag agaacatttt tggaacacca tgagcggcca 1681021 caatccgaag gtgaaaaaag cagtttgccc atcaggcaca ttcgagtatc aaaatcttca 1681081 atatgtatac atgtgcagtg atctaggcac taaagcaaaa gcggtgaatt atttaactcc 1681141 tatttttaca aaaacagcaa tcgaaaaagg ctttaaagat tatcatttca ctgtttcaaa 1681201 aggaaaactt gctgttccaa tcggtgacgg agacaatctt ttgaattgga aaaaatcaac 1681261 tgctaaactg atctctaaaa aaggcagcac aatcacatac gaatttactg tccctacatt 1681321 agacggatcc ccttctgcaa aacggaaagt gacatttgtg aaagaaaata aaaaatggaa 1681381 agtcaatcaa tttgacgcag ttatataaga aaaacgcccg gtataagcgg gcgtttttta 1681441 tttggtttgc ataaagaaag acaacaggcg aaaagtgcct gttgtctttt tgtgaatata 1681501 acgctctagg agagattcga actcccgacc tgcagtttag gaaactgctg cactatccgc 1681561 tgtgctacta gagcttttgg tatttatata gtagctctga tgatcaatat tttcaagcga 1681621 tttgtattaa agccctccaa aaaccttata tgcggctctt gtcgtatctt catcaatacc 1681681 gatataccgc attgtaattg atggtgatga atgattcagt attctctgca gctcggcgat 1681741 gtctttcgtt cgctgataaa aatgatagcc aaacgttttc cggagtgtat gcgtccctat 1681801 ctcctcaagt ccgcacgctg cagcggcctc tcttaaaatt ctgtaggcct gaatgcggga 1681861 aatcggcttc ctggtccgca ctgatttaaa aagatattcg ttttccttca tgtctttcgt 1681921 atactcgtat atttcctgtt tcagcgattc taaaataaga atctttcttt tctttttcgt 1681981 tttgctttca gtcgcccata aatgatcttt attttgaacg tccttcactt gcagcggcag 1682041 aatatcagaa atacggagcg cgctgttgat gccgaaaata aacagaaaat aatcccgctt 1682101 gtttttgtta agcaaatact gtttgacttc ttggattttc tctagactgc gaatcggctg 1682161 tacaatatgc atcaaaaaac tccttaaaaa ccgttatgta acattttgag gtctatgtta 1682221 ctattatagc tgaaaaacgt tgaatgtcaa agtgcggcgg cgtttatgta acataatata 1682281 catagtgtta cataagcttt taaaaaagct tcttccaacc ttcaccctat aaaataagct 1682341 ttaaagcctc ttataaagct tttaacctct tggatactta tccccctact aatcatcaaa 1682401 aaacctctta aaatgaaatc tgacactccc aattttctgg agcttccgca aaaatataca 1682461 aaaaaagaca caatttcaaa ttgtgtccta atcctcatcc tttacatcaa tatcttccgg 1682521 gatcggttca tttaatattt cctgcacaag tgctttgtaa ttctccagct gttcgagatg 1682581 cgttttgaac tgttccttat aaatcaaaaa ttgctccccg tcatgaacgg ctctgatttt 1682641 cccttcgagc accaagcttt taatataatc ctctgaaaga tttgtatatt ctgctgtttc 1682701 ttcaatcgtt aaatacatat agcagtccct tcttaatccg tatgctgatt ctaatatagc 1682761 acatggctca tatcaatata atcaattctg cacagaaaaa cggcattatg cactatataa 1682821 tataccattt gtcacttgtg aaaacgctgt aattttttta cgctaagatt gtaacaatac 1682881 agcttcatat aggagggaga acatgaaaag aacgtggaac gtctgtttaa cagctctgct 1682941 tagtgttctg ttagtcgctg gaagtgtccc ttttcacgcg gaagctaaaa aaccgcccaa 1683001 aagctacgat gagtacaaac aagtagatgt tggaaaagac ggcatggttg cgaccgcaca 1683061 tcctcttgct tctgaaatcg gtgctgatgt gctgaaaaaa ggaggaaatg ctattgacgc 1683121 agcggttgcc attcaatttg cactcaatgt aacagagccg atgatgtcag gtattggcgg 1683181 cggcggtttt atgatggtgt atgacggaaa aacgaaggat acaacgataa tcgacagccg 1683241 tgagcgtgct ccagcaggcg caactcctga tatgtttctg gacgaaaacg gcaaagcaat 1683301 tcctttctct gaacgtgtaa caaaaggtac tgccgttggt gttccaggca ctctgaaagg 1683361 gctggaagaa gccttggata aatggggaac ccgttcgatg aagcaattaa ttaccccttc 1683421 tattaaactc gctgaaaaag gctttccgat tgattcggtg ttggcagagg ccatttctga 1683481 ttatcaggaa aagctttcac ggactgccgc aaaagatgta tttttaccaa atggcgaacc 1683541 gcttaaagaa ggagataccc ttattcaaaa ggatttggct aaaacattta agcttattcg 1683601 ctccaaaggc actgacgctt tttataaagg aaaattcgcc aagacgcttt ctgacactgt 1683661 ccaggatttc ggcggatcaa tgacagaaaa agatttagaa aattacgaca ttacaattga 1683721 tgaaccgatt tggggagatt atcaaggcta tcaaatcgct actactcctc ctccaagctc 1683781 cggcggtatt ttcttattgc aaatgctgaa aatccttgat cattttaacc tttcacaata 1683841 cgatgtccgc tcatgggaaa aatatcagct gcttgctgaa acgatgcatt tgtcatatgc 1683901 cgaccgtgcg tcttacgcag gtgatcccga atttgtaaat gttcctctca aaggcctgct 1683961 tcaccccgat tatattaaag aacgccagca attaatcaac ctagatcaag tgaataaaaa 1684021 accgaaagcc ggtgaccctt ggaaatacca agaaggatca gcaaactata aacaagttga 1684081 acagccgaaa gacaaagtag aaggccaaac aacccacttt acagttgctg accgttgggg 1684141 aaatgttgtt tcttatacaa caacaatcga acagctattc ggaacgggta ttatggtccc 1684201 tgattacggt gttattttaa acaatgaatt aacggatttt gatgcgatac caggcggagc 1684261 taacgaagta cagccaaaca aacggccttt aagcagcatg accccgacga ttttatttaa 1684321 ggatgacaag cctgtcctca cggttggatc tcctggcggg gccacaatta tttcatccgt 1684381 tttgcaaacc attctctacc acattgaata tggtatggaa ttaaaagcag ctgttgaaga 1684441 gccgagaatt tacacaaaca gcatgagctc ttaccgttac gaagacggag ttcctaaaga 1684501 tgtcctcagc aagctaaacg gcatgggcca caaattcggc acaagtccgg tggatatcgg 1684561 aaacgtgcaa agtatatcga tcgaccatga aaacggcacc tttaaaggtg tagctgattc 1684621 aagcagaaac ggcgcggcga tcggcattaa tttaaaacgt aaataaataa aaaactgtac 1684681 tcgcttcaaa tgagtacagt tttttcatgc agatctttaa aataaaaact gacaaacgtc 1684741 tttattctgc taatgcacgt ctatcttcat cttttcattt cgtttatctc atcaagaaat 1684801 gtctgaaacg cactcgtaat aaaaaagtct ttcctgtata taaagacgat ctctaagtct 1684861 tgatatgatg gtggcagctg atgaatccat acatttgtac gatgctcgga gccgtcaaca 1684921 gcggactttg ggagcagcgc cgtacccatc ccggcggaaa caccttttat aatagcctcc 1684981 aatgtgccaa actctatgat tttttgattg tgtatgcctg cttcctctag taatcttttg 1685041 accctgtcac gatgagaaca gccagcccca aaaaagagca tcggctgctg aagcatgtct 1685101 tctgccgtcc cttctcgtga tgaaatcaaa actaattcat catgggagac atggagttgt 1685161 ctaactgcag cgtgttcaac cggcccatat acaaaagcgc catcaacttt atgatcaaga 1685221 acctgttgaa tcaaatgatg cgtatcagct gtgttcactg ataaatccac ttcaggaaaa 1685281 cgcctgagga aggatgctgc atgctcaggc agatgcgtta ccgccattgt ttccagtgat 1685341 ccgatccgca aaggcccttt tggttgcctg ctcattcggg tcgatttttc agcttggtct 1685401 aacagcgata atacttgatc tgcatattgt aaaagatttt ctcctgcagc agtcagcttc 1685461 attccccgat tcgttcgatg aaaaagcctg atattcaaat cttcctcaag gttatgcact 1685521 ctggctgtca cattcgactg aacataattc agcatttggg ctgctttcgt tatgcttcct 1685581 tcgcgagcaa cagcctgaaa aatctttaaa tctccgcttt ccacgcgctc tcacctgctt 1685641 gctatgatga aaagtgatat tggctatcat atttgttcat tttactcgaa gaaaaccgct 1685701 atgtaaaata tgtaaagata tgaaaataca attaatgagg aggcagacag catgaaagct 1685761 gtaattcaca acggaaaagc cggtcttctg gggttatcag ttcaggacgt tccatcaaca 1685821 aagcctggat acggagaggt aaaggttaaa ttaaaatctg caggcctgaa tcatcgtgac 1685881 ttgtttctta tgaaaaacaa atctgaacaa gatcctcaca tgatactggg ttctgacggc 1685941 gcgggtatca tcgaagagat tggtgaaggc gtgaaaaatg ttactgttca gacagaagta 1686001 gtcattttcc cgacattgaa ctgggatttg acagaaaatg ttccacctgt acctgagatt 1686061 ctgggaggtc cttcggacgg aacacttgct gaatatgtga tcattccttc acaaaatgca 1686121 atcaaaaaac ctgcttattt atcttgggaa gaagcgggcg ttttaccttt atccgcttta 1686181 actgcatatc gggctctgtt tacaaagggg caattaaaaa aaggcgagca tctattgata 1686241 cccggcatcg gcagcggtgt agcaacctac gctttattta tggctaaggc gattggggca 1686301 acagtaagcg tgacctcccg cagtgaggag aaaagaaaaa aggcgctgaa attaggtgct 1686361 gattacgcat ttgacagcta cagcaattgg gatgagcagt tgcagggaaa aaagatagat 1686421 gttgttcttg acagcatagg acctgccctc ttttcggaat acttccgcca tgtaaaacca 1686481 aatggccgta ttgtcagctt tggggcaagc tcaggggata atctcagttt tccggtgcgt 1686541 tctttattct ttcctcaggt caatgttttg ggaacctcga tgggaagcgg tgaggaattt 1686601 caagctatgc tcgctttcat tgacaaacat aagctgcggc ctgtaattga ccggatatat 1686661 cctttagaaa aagcatgtga agcatataaa agaatgcagg aaggcagaca gtttggaaac 1686721 atcgggatcg taatggaata aaaaaagaaa ccggctggca gccagaccgg tttctcttat 1686781 atgataatcc cctttattta cggaagaact gaactcccca tcaaatatcg atccacttca 1686841 cgcgccactt cacggccttc attaatcgcc catacgatta agctttgccc tcttcttgca 1686901 tcccctgcgg cgaatacacc atcgatattt gtttgataat ccccatatgc tgcactgatt 1686961 ttgttattta ctgaattaac accgaactgt ttcaacagcg gctgttctgt gccttcaaag 1687021 ccgatagcga taaagacaag ctgagcaggc catacttttt ccgttccagg cagctcgcgg 1687081 aactcgtatt ttccatgctc atttttcact ttttccattt ggatggtatg aagctctttc 1687141 agctttccgt ttttatccgc gaccattttt gtcgtttgaa tggagtattc tctcggatct 1687201 cttccgaatt ttgcttctgc ttcctcgtat gcatattcaa gcgtaaagac gtgtggctgt 1687261 tcaggccaca tattgtcatt cgtgcgggct ggcggaagtt tcgggtgttt gccgaattgg 1687321 tgcacgcttt tggctttttg acgcagagcg gtagccacac agtcagctcc tgtatctccg 1687381 cctccgatta cgatgacatc tttccctttg gcatcaatga attgcttgtc tttaaaatta 1687441 gaatctaaat agctttttgt tgcaagtgtg aggtagtcca ttgcgtaatg gactcctttt 1687501 gagtcgcgtc cttcgattaa gaggtcccgc tgtttttgag cgcctgtgca taagatcaca 1687561 gcatcaaatt gctcctttag ctcatcagct gtaatgtcaa caccgatttc tgtgttcgtg 1687621 acaaaatcaa ttccctcttg cgtcagcaat ttaattcggc gttctacaat gcccttctca 1687681 agcttcatgt ttggaatgcc gtatgttaaa aggccgcccg ctctgtctgc tcgttcaaaa 1687741 acagtgacgg aatgtcccgc ttgattcagc tggtcagcac tcgccagtcc ggctgggcct 1687801 gacccgacga tggccacttt tttgcctgtt cgtttttttg gaattctagg ttgaatccag 1687861 ccgttctcaa atcctttatc gataatggtc cgctcgatgt ttttaattga tacggccgga 1687921 tctgaaatcg ctaaagtgca tgatccttca caaggagcgg ggcatacccg ccctgtgaat 1687981 tcaggaaagt tgtttgtttt caacagacgt tccaatgctt ccttccatct gccccggtag 1688041 acaagatcat tccattcagg aattaagttg taaatcggac agccggatgt aaatccgtta 1688101 atgtccgcac cgatctggca aaacggtgta ccgcaatcca tacaccgcgc cccttgccgt 1688161 ttcgatgctt cttctgaaaa aggagcagaa tattctttcc aatcctttaa gcgagtgaga 1688221 gggtcccgct ccgcaggttt ttctcgtttg atctccataa atccagttgg tttccccatg 1688281 ttcctctccc cttccttact gtactaccgc ttgtttttgt cccgatgctg ctgtattctg 1688341 ctttggcttc gtgttggcct caaaagcgaa catgatggct tcttcatctg ataaacctgc 1688401 agctttttgc tcttcgatgc ttgcgagcat ttgtttatag tttttcggaa tgactttgac 1688461 gaattttttc acactgtctt cccattgatc tagcagatct tctgcttttt ggctgtttgt 1688521 atacgcagta tgtctttcaa gcattgcttt gatttgctgg atttctttct catcctctaa 1688581 tgattcaaat aaaatcatct caaggttgca tttgcgttta aacgctttga catcttcggt 1688641 cagtacataa gcgattccgc cggacatacc tgccgcaaag tttttgccta catcaccgag 1688701 aacgacaacg ctgccgccag tcatgtattc acagccgtgg tcgccgatgc cttctacaac 1688761 tacgttcaca ccgctgtttc gaacggcaaa gcgttcacca gcacgcccgt taatatatgc 1688821 ttctccgctt gtcgcaccgt aaaaagccac gttgccgata atgacattgt catccgaagc 1688881 agagttgaat ccttctgatg acttgacgat gatttttccg ccagaaagcc cttttccgac 1688941 gtaatcattt gagtctccgt ccaaataaag cgtcatccct ttaggaacga aagctccaaa 1689001 gctttggccg gctgatccgg taaagtgcag cttgattgta tcttcaggaa gaccttcttc 1689061 tccgtaacgc tttgagattt cactgccggt tatcgttccg gctacacgat ttgtattatt 1689121 gatttcaatc gaaatatcag cttcttttcc agattcgatg gcttcttgta cggccgggag 1689181 aattgttgta atatcaagtg attgatcaat tttatgattt tgcggcgatt ggaacgtccg 1689241 caccccttca ggctgataaa gaagggtaga caaatcaagc tggcttgctt tccagtgctc 1689301 ctttgcccgt tcacttgcat gaagtacatc agtgcggccg atcatttcat caaatgtctt 1689361 gaagcctaac gcagccatgt actcacgaac ttcttcggca atgaacagca tatagttcac 1689421 aatatggtca ggatctccca tgaacttttt gcgaagctct ggattttgtg tcgctacacc 1689481 gacagggcat gtatccaaat ggcaggcacg catcatgaca cagccgagta caactaacgg 1689541 agccgttgcg aaaccaaatt cttcggcgcc gagcaaggca gccatcacaa cgtcgcggcc 1689601 cgtcatgagc tttccatctg tttctaatac aacacggtca cgaagtccgt tcagcattag 1689661 tgtttgatgt gcttctgcaa ggccaagctc ccacggaagc cctgtatgtt taatactggt 1689721 tttcggagaa gcgcctgtac ctccgtcata gccgctgatc acaatgacat ctgcagtcgc 1689781 tttggcaaca cctgcagcga ttgttcctac acctgctttt gacaccagct ttacgctgat 1689841 tcttgcgtca cggttggcat ttttcaaatc gtggatcagc tgggctaaat cctcaatcga 1689901 ataaatgtca tggtgtggcg gaggtgagat taatccgaca cctggcgttg acccacggac 1689961 atcggcaacc catggatata ccttgttgcc aggaagctgc ccgccttcac ccggcttagc 1690021 accttgagcc attttaatct gcagctcatc agcattgacg aggtaatggc ttttgacacc 1690081 aaaccgtccg gatgcaattt gtttgatcgc acttcttcta tcatcgccgt tctcatctgg 1690141 aacaaagcgt ttgggatctt ctccgccttc accgctgttg ctttttcctc caagacggtt 1690201 cattgcgatt gctaaagctt cgtgcgcttc cttactcaag gacccgaatg acatcgcacc 1690261 cgttttaaaa cgtttgacaa tcgattcagc ggattcaacc tcctccaact tcaaaggctt 1690321 gcggtttccg tcaaatgcga acaagttccg caaaaatccg atgcgttctt catcagccgc 1690381 ttttgtatac tgtttaaaca gattgtaatc atttctgcgg cacgcccatt gcaaagtatg 1690441 aatcgttttc ggattaaacg catgatgctc tccgccattt ctccattgga agtcacttcc 1690501 cggttcaagc gttttgctgt aatcatcctg atacgcttcc cggtggcggc gctgtgcctc 1690561 ttctgcaatt gtttgtaaat cgatgccgcc tagctgtgat gcagtacctg agaaatagcg 1690621 gtcgatcaca tcgcggctga ttcctaccgc ctcaaagatt tgtgcgcctc tgtagctttg 1690681 cacagttgaa attcccatct tggacatcac ttttacgacg ccctcagtaa tgctttttcc 1690741 atatttgcta accgcttctt catagctgat atccaaacgg ccttcatcaa tttcctgctt 1690801 gtaggtcgca taagcgagat aagggttaat cgcatctgcg ccataaccga ttaacgctgc 1690861 aaagtgatgc acttcacgtg cttctcccga ttccacaata atgctgacct tcgtacgcag 1690921 ccctttgcgg attaagtgct ggtgcagtgc gcttactgcc agaagcggcg gaattggtgt 1690981 cagtcgttcg ttcatctttt tgtctgataa aattaacaaa cttacgcctt ggctgatggc 1691041 tttctctgcc tgtgtgaaca tgtcctttaa accgcgttca agatcctctg aaaacagcac 1691101 atcaattttt tggcttttta aatcaggatg aacaatcgtt ttcaatgcgt aaaactgttc 1691161 attggataaa acaggtgtat acagtttaat ccggcgaaca tttcgttcac ttggatgaag 1691221 aagatcgcct tccgcaccga gccaagtcat cgttgaagtg acaagctgct cacgaatcgc 1691281 gtcgattggc gggttcgtta cttgtgcaaa cagctgttta aagtagttaa acagcgattg 1691341 cgctcggtca gaaagtacag caagcggagc gtcattcccc attgaaccaa ggggatcttt 1691401 gccttcttta ataacaggaa ttagatactt ttggatatcc tcatatgtgt atccgaatgc 1691461 cttctggcga gtaagaagat cactaaattg ttcttcttct cttgactccg gatcaggatt 1691521 tacttgtaca agctcttctt caagccattt ttggtacgga tactcagttg caatttgtgt 1691581 tttgacttcc tcatcggaga taatacggcc ttcttccagg tcgattaaaa gcattttccc 1691641 aggctcaagg cggtttttat ataaaacgtt ctcctgttca acttcaataa cgcctacttc 1691701 agatgagaaa ataatataat catcttttgt gacataataa cgggccggac ggagaccgtt 1691761 ccggtcaagg atcgccccga tttgtttacc gtcagtaaat gaaatagctg tcggtccgtc 1691821 ccaaggctcc atcagggagc tatggtactc gtagaacgcc cttttttcct tggacatatg 1691881 cgtattttcc gtccaaggct ctggaatgag catcattgcc gtatgtgccg gtttgcgtcc 1691941 agccatcaca aaaaactcaa atgcgttatc caaaatggaa gagtcactgc catcagcatt 1692001 gagaatcggc aaaatcttgt ttaagtcctc accgaagctt tcagaaacaa attgctgctc 1692061 acgtgctctc atccagttga tatttccgcg aagggtgtta atttcaccgt tgtgaaccaa 1692121 atagcggtta ggatgcgctc tttcccatgt agggaatgta ttggtactga agcgtgaatg 1692181 aacaagcgca aaagcagaaa cgaatgcttc gtcttgcaga tcagaataaa atgcatcaac 1692241 ctgttcaggt gttaaaaggc ctttgtaaac aatggtctgg cttgaaagac tggcaaaata 1692301 aaaatcaaga ccttccgtta ctccccaatt ttcagcctgt ttacgaatga catacaattt 1692361 tcgttcaaaa gataaattgt cctttagatc agaacttgcg ccgataaata cctgacggac 1692421 aaacggacag cttttttgcg ccactgttcc gatttttccg acatttacag gtacagttct 1692481 ccatccaaga acgacttggc cttcttgttc aattagtgca ttgatttgct tttcaatttt 1692541 ttttctttca tcttccttct gtgagaaaaa gaccattcct accccgtaac gttctttttc 1692601 tggcagattg atgtttttgc actcttttct aaagaaagca tcagggattt gaaccagtaa 1692661 gccggctccg tctcctgtat ccggatcact gccttgccct cctctatggt ctagctggca 1692721 aagcatctta agtccttgtt tgacaatgtc gtgagtctgc ttgcccttta agtgtgcata 1692781 taggccgatt ccgcatgcat catgttcaaa ttcaggacgg tagagacctt gagcttttgg 1692841 catttgattg tacgtcataa ttcctctccc ccgatcaatt tccgataata ccggtcataa 1692901 aatctaacaa ctctataatc attgtaggtt ttcaaaacga tataaacaat atataattta 1692961 gatcaaaaga atctcaaaat gagatagatg gatgtgagac aaacatggag ctgcgccaac 1693021 tgcgttattt tatggaggtg gctgaaagag aacacgtttc agaagccgct gatcatttgc 1693081 atgtggccca atcagcaatc agcagacaaa ttgccaatct tgaagaagaa ttaaatgtga 1693141 ccttatttga gcgtgaaggg agaaatatca aactcacgcc aatcggaaaa gaatttttaa 1693201 ttcatgtgaa aacggcgatg aaagccattg attatgcgaa agagcaaatt gatgagtatc 1693261 ttgacccgca tcgcggaacg gtaaagatcg gctttcctac aagcctcgcc agccagcttt 1693321 tgccgactgt catttcagcg tttaaagaag aatatccgca cgtcgaattt ttgctgcgcc 1693381 aaggctccta taagtttctg attgaagctg tcagaaaccg cgatattgat ctggccttat 1693441 tagggccggt gccgacgaat ttctctgaca taacgggaaa aatattattt actgaaaaaa 1693501 tttacgcgct tgttccatta aatcatccgc ttgctaaaca aaaaacggtt catttaatcg 1693561 atttgcgcaa cgaccaattt gtattgttcc cggaaggatt tgtacttaga gagatggcaa 1693621 tcgatacttg caaacaagca ggctttgctc ctctcgtttc cacggagggt gaggatttgg 1693681 atgcgatcaa agggttagtg tccgcaggaa tgggcgttac ccttctgcct gaaagtactt 1693741 ttgctgaaac aacacctcgt tttactgtga aaattccaat tgagttccct caagtaaaac 1693801 ggactgtcgg aatcattaaa ccgaaaaata gagagcttgc gccttccgcg aatgattttt 1693861 atgagtttgt cattcaattt ttctctaagc tggagcagta tcaataaaaa aaatgaaccc 1693921 gagcttctat atagaagctt cgggtttttt tctgcaaatt aatttacagg taaagaaaaa 1693981 tccacatggc aaacaaatgc ttcttgatca attagagctc tatttgtcag ttcctttttc 1694041 ttttccggtt cttgaagctg tacagaagag taattgacga ttccaaggcc gatttccgtc 1694101 ccttttgaat ccatcagccg aacaactgaa ccgcttttga atttcccttt aatcttctgt 1694161 acaccgtcta ggtataaact cgattgtccg tttgttattt ttcgtgaaca atcatctgat 1694221 aaaatcattt caccttccgg accggaatta aaagcgatcc attgctcctt ttgattcaac 1694281 ggaagcgttc cttctgcttc aaaataggtg ccttccgcct gttcatgaac ggcgtggtat 1694341 aaaatatcgc cagcatctgc ctgacctagg aaacctttaa tgccagacgc cattacgatt 1694401 ttaaacgcat caagcttaga gcgcatgccg ccggtgccaa cgatgcttcc agtgtcacct 1694461 gcgcatgctt cgatgtcagg tgttatttca ctcacccgct gtatcttttt cgcttctgga 1694521 tttgtgcgcg gattgccgtc atataatccg tctatatctg ataaaatcac aagcatatct 1694581 gcatcaatca atcctgcgac ttttgctgcg agcgtatcat tgtcgccaaa cttgagccga 1694641 ttgacggtaa ctgtgtcatt ttcgtttatg atcgggatga tgccgcgctc gagcagtaca 1694701 ttcattgtat tcctgacatt gttgtatcga tattcatcag aaaaatcgct tctcgtaatt 1694761 aaaatttggg atgcgacata gccgtgtgcc aaaaacagct ttgaataagc ctccattagc 1694821 aatccctggc cgattgaagc tgatgcttgt ttttctggaa gcttctcggg cctttggata 1694881 aatccgagct tccgatatcc cgccgccact gcgcctgagg aaaccaaaat cacttcataa 1694941 ccggcgtctt tgagtttgac gacctggtcg accaacgctt ctaattttcg aatgctgatt 1695001 tctccatgaa ggcttgttaa tgaactgctt ccaatcttca caacgactct tttcatgctt 1695061 gtatcaggcg tcactttatc actcctgata gcggcgctgc agttttttcg atatcttcgc 1695121 tgatttcctt tgaacgctta gccgcatgct ttattgcttg agaaatcgct tctccgccgc 1695181 cgctcttttt caaggcttgc agccccgctg ctgtcgttcc gttcggtgac gtgatattat 1695241 ctcttaagat ctcaggatgt tctcctgttt ccatgagcat ttttgcggca cctaaaagtg 1695301 tctgtgcgcc gatgcttcga gataactgtt tatcgaggcc cgcttcctcg cctgtctttt 1695361 caatgaattc cattaaataa taaaaatacg cgggtccgct gcctgcaatt ccggtgaata 1695421 tatccatttg attttcttgg attgtataga cttcgcccat gcatccgagc aatgcttcgg 1695481 ccagcttctt caggtcttcc gacacatatt tgccaagggc aatagctgtt gcagaagcgc 1695541 caatcatact ggaagtgttg ggcatcactc tgacaaccgg ctgttcatta agcaatgatt 1695601 gttcaataaa agaggtagtt atgccggcaa ggaccgacaa tattaattga tggggttgaa 1695661 tacgtgattt tagtgatgac agagcgtttt cggcgtcttt tggcttcatt gccaaaatga 1695721 gcacatccat gtcttcaata catagttggt tcggcaaggc gcctttaatg ccatattgaa 1695781 gttcaagttc agttaatcgc tctgtattgc tgcggtttgt aacgcagatg ttttgtttcg 1695841 ggattttgtt ggctcgaacg atacctgata tcattccttc cgccatagat cctgctccta 1695901 taaaggctac tttcttttga tcaaagatcg gtaacatctc ctttgttcgc ttttttgttc 1695961 gcattttcac acgtttaaaa tgttaccacg tgaggaaatg atgtcaagtt tgaaggccat 1696021 tattgatttg tattgtttct tttcgacaaa tatgtataat gaaaagcaga aaacacccgg 1696081 ttcacactgc tgcgccgggt gtttgtttct attaaaaatt atctgagaga gctttttcaa 1696141 tcagtttttt acagcgatcc agctctacct tcagctgttt tttatatagc ttggcagctt 1696201 cgtaatcttt aaattgatag aggacgactt cctggagctt agccccttct ttttttactt 1696261 taatttgttt tagtatcccg tcatcaagaa gctcatgcaa agaccggtat acttctgtat 1696321 gatttggttt aaaaccaatc tctttaaatt cagaccgaag tacttcaagc agctttaacc 1696381 catagagtct ctcttgctct gtcatcgtta tcatataaag cttcaaaaat gcgcgctgtt 1696441 tcactaaaaa gcctgttgaa ctcctttttt cttctttcat catatgcact ccttcttctg 1696501 tcactgacaa cactatgtac taaatattca attttctttt attgttttcc ttctttatat 1696561 taaagactga tagtccagtt atttcatgtt tactgattat aggtgtagcg gaaaaaataa 1696621 atttcgactg aacatttggt acatagtttt cttagttcta ttatagcctg catttactgc 1696681 tatcttcaat ttaaacgatt gccagggttt acatatctca ttttaccggt acggatttca 1696741 ttcaaataaa aaaacctgtc gaaagacagg ttttcatttt taaggatttg ttgaccataa 1696801 tcccgctgtt ttgatgaaaa tacgaggatc taatttcagt tgtgccacca tgtactcagc 1696861 aagatcctca ggctgcataa ctttttcagg attaccgtct gttaagttca attcgataga 1696921 catatcacta gcgacagtgc tcggcgttaa cgcgctgact ctgatattat gttttctcac 1696981 ttcttgcata agagactctg ttaacccgag aacggcaaat ttagaagcgc tgtaagcact 1697041 tgttacagca gctcctcttt ggcccgctgt agatgaaata ttaatgatgt ctccggcttt 1697101 gcgttcgatc atttccggaa gcaccgcgcg agtgacatgg tacacaccca ttaggttgac 1697161 ttgaataata ttttcccact catcagctga cagatctaag aaaccgccaa atttgctgat 1697221 gccggcatta ttaatgagga tatcgatatc accgagctgt tccttcactt gagctacagc 1697281 ttggttaacc tgatcggcat cttttacatc tgcagcagca aatgcagctt ttacaccaag 1697341 cgctttgact tcttcagcca ctttttctac attagcggaa gtccggccaa ttaacccgat 1697401 attcacgcct tctttggcaa gcgccagagc agtagcgcgg ccaattcctc tgcctccgcc 1697461 tgtgattagt gcagttttat gttgtaaact ttgcaattga agcacccttt ctttgtttac 1697521 atatgtacga tatcacatta taagtacaat acatccaata cgcaaatcaa acgaactgtg 1697581 taaatatcat ttcttctgat taaaaaaacg gatacagggt aatgacataa gaaaaggagt 1697641 gaacatatga ttatagttta tatcagtctt gcagtattag cagtttctat tatcttctta 1697701 ggagttaccg tgatccaaaa caagaaaaaa atagaccccg cactaaagga gctttcctct 1697761 gttacgcagg ctatgcaaaa acaaatcgaa ggattaaaaa cagaaacaga gctgctgacg 1697821 caaaaacaaa agaagattca gcaggatgtc caaataaaaa aatacacgct tcagcagacc 1697881 gcagctgaag tgaaagaagt tccccaagca gtcaaagagg tgtggcaggc aggacatttt 1697941 aatagcagat aaggatgaat gagatcccgt tgttacgatc agaatggaca aatgggatct 1698001 catttttcga ggaggcttac acatgattat aaaccgcagc tgcttaaaag agttcgcaga 1698061 aaaagtacat tttcttccct cttcacttac aaagtccgat ttacttactg atccatttcg 1698121 tctccatcaa gaaaacgaac ttggcatcta ctattcacct cataatgaat ttatcaatcg 1698181 ggatgcctcg cttgtgattg ccgggatcac gcctggtttt tcccagatga agacagcgta 1698241 cgaaacagcc gccgaaagcc tgctgcaagg cgggactctt gagcaaatgg cagtagacac 1698301 aaaaatagca gcgggtttct ccggatcgat gagacataac cttattacca tgctggattt 1698361 atgcgggctg ccgcaagctt ttggcattca aagcgccgca aagctttttg gagaattacg 1698421 gcatatgctc catacaactt ccgttattaa atatcctgtc tttatccagc aaaaaaacta 1698481 taccggatac aaaccggcta tcactcattc tcctatccta agcacttatg cttttgggca 1698541 cttccctgca gagcttaacc atgtgacggg accagctctt ctcattccgt taggaaaagc 1698601 ggccgaaaca gtgtgtgaaa cattgatcag acagcacagc ctccagaatt tgatttgcct 1698661 taacggcttt ccccatccat caggcgcgaa cggccatcgt ttgaaacaat tcagcaaaaa 1698721 caaagagcaa ctagaaagac aaattcgttc ctttgctgca ttggttgatt tcgctataga 1698781 aaagaggaaa taaaagggat atgataaaca aaaacacaaa cgtggggagt ggttgaatgt 1698841 ttcctatatt agaaacggat cggcttatac ttaggcaaat cacagatcag gatgcggaag 1698901 ccatttttgc ttgtttctca aacgatgagg tgacacgcta ttatgggctt gaaaacatgg 1698961 aatctataga acaggccatt tcaatgattc aaacgtttgc tgccctctat caagaaaaac 1699021 gcggtatacg gtggggaatt gaaagacggg acactaaaga actgatcgga acaattggct 1699081 ttcacgctct ggcccaaaag cataggcgcg cggaaatcgg ttatgaaatc atcccggagc 1699141 attggcgaaa cggatttgca tcagaagtca tttcaaaggt cgtatcttac ggattttctg 1699201 cccttggact gtcgcgtatt ggcgcagttg tatttaccga taatgaagca tcaaatcgtc 1699261 tgcttctaaa aatggggttt caaaaagaag gcgttttaag acagtacatg tatcaaaatg 1699321 ggactccata tgatacaaat gtgtactcta ttgtgaaacc aagagaatga cggtattctc 1699381 ttggtctgtg ccacatccct tttcctttaa aaagataaaa agcgcccctc aaacagggcg 1699441 ctttctaatt aagatgcata ttgaggagat gtttcctcct taactgcttt ttcctcaggt 1699501 atatgaatac attttgtcaa gaccgcactt gcaaggtaaa gggccgcaaa gatccagacg 1699561 acaccttgcg cgccgacgag accgatgaac agccaagcga gtgcagggcc gacaaacgct 1699621 gataaacctg cagctaaatt caatacagac atggctgccc ctttatcttt tcctgccacc 1699681 gtcggcacaa ttgcaccaat cggcacatag cctgccagca aaccgcccca aataaagccg 1699741 atcacgctga caaccgctaa acttccgccg gagaaaacag gtgcgtagta taataagacg 1699801 gtgaaaatgc cgcagccgac tccgccgaac caaataacag tatttttcca gccgaattta 1699861 tcgccgacaa taccgaagat aaggttaaac acaatgttcc ccaggaaaat cgttccccaa 1699921 atttgcagcc acacattggt tgaaattcca tgctgggcca tgtgcatcgg caaaaagact 1699981 ggaaaaccat atgtaccaat gctgttgatg attctgatga ttccgcctgt aagcacgcgc 1700041 ggatttgtaa atagaatcgt aacccctttt aaaagctcct cggctgtttc tgatcttttt 1700101 cttttcttct tttcaaaacg gtctttattg ataaacaatg caaagaatgc accgagacat 1700161 acccagaaaa tagagctcca aagcgtattc aaataaccga acgctttgat cgcgtagctt 1700221 gagtaccaag cgccgaacac aaacatgccg aggcaatatg caatccaaaa ccagccgaca 1700281 gcagtgctca gtttgctttg cggtgttctg taaatgaccc atgtcaagaa agaataagca 1700341 aaaagcgggt aacctaaccc ttttacgaag taagtcacat acatcactgg caggttcagc 1700401 tgttcaaatc caaatacgat aaaagcagct gtaccgatca cataaaacaa cagccccata 1700461 aacatcgttc gttttgcgcc aaatgcttcg agacatacac ccgaaaacca ggaagctatg 1700521 gcaagcgcaa ttccgtatat actaaaaatg gaagcggact gctgaacggt gagcccgttt 1700581 tcgatcaaaa aaggactgag ccagccttgt tcaaggccat ctcccatcat aaacaaaaca 1700641 acccctaaaa atccccaggc aagccgcttc ggtattccta ttttatccaa catatctgtc 1700701 tcctccttag atgctattat tcattaccgt attaccttat taaagttgaa aattaaatga 1700761 ttcctcaaaa cagcagaaat tccgtcttaa attaatactt tgctttctga tcctgaaaaa 1700821 aagcgctgtg tttgcttcca ttcctcatat aaagccaatt ctatctgaca gtccttcggt 1700881 tcgatcaccc ggacatttgc tgacatctcc tccgttaatt gaaaggtttc attgcaaatg 1700941 actgcagcac cgacgacaga tgcctgatga tatccctctt ggacatagac ctttttttga 1701001 agaagatccg cgatatattg agtgagcgct ttgctttgga atccccctcc gcacacccaa 1701061 acataatcac gttcaaacgg agtaacctct gttaaaatgt caaagttcca tttgattgaa 1701121 aatgcgatct cttctagcgc tgcacgtaca aaatgtgccc tctttaaatg tgctgacagc 1701181 ggggcatcaa aaagaaaacc gcctctcgtt aacgcattct tttcagccga taaataagag 1701241 ccgagagccg ctacacatgc atggtcttct tttgcaagtg cagaaatctc ctcctccatt 1701301 acttcgtacg tttcattcgg ataaaaaatc tgttttaatt tttgataatt caagccggta 1701361 attcccggat tcgtttccac aagccaatgc ccttgatccg tatgacagtt caaccaggct 1701421 ttatgttttg tgtcgccatg atcctcagta attttggtta ttggcgttgt tgtccctgat 1701481 acaatgacaa tgtcctcaag tccagctccg gtgcttttga cagccagctg tgtatccccg 1701541 ccccctgcta taaccttagc atttattgaa aggcctaatt cggatgcata ttcatttgct 1701601 atcgttccaa ttgctgttcc cgctcttaca agaggcggaa ggatagatgg agaaaagccg 1701661 aaaatgtcgc acatctcttc tgaccaagtg ttttgcttca catcaaatag cagggtttct 1701721 gttgcctgtg atggttcata tgttaatatt ccgctcagtt ggtacgtcac ccaatcactg 1701781 atgcttgtaa agcttgcagt cttttcccat aaagagggct ggcgctgttt taatccataa 1701841 agcttgagcg cagaaaaaag tgcagttggc aggcggcctg tgctgctgta tatctcttcc 1701901 caatcgggaa tgcccgcctc ccactctcgg ccgcgattat cgatgttcgg cagcccgaga 1701961 aaaggattgc cgttttgatc aatcaaaaca atcccctgtc tttggctcgt cgatgtcaaa 1702021 ccaatgatgt caatatcaca cgaacgggat agcgcacgtt ttgccaaatt catcacctgc 1702081 ttccacagca cctgaggaga aaaataacgg ctgtccgggt aaagcgtctc tgtggaatac 1702141 tcgatgtcct cccgttcaac tgttagaaca ctgccagtta cactcacgac cgctaccctc 1702201 gcattgcctg tgccaatatc aaaaacgaga tagccttttt gttttttcat tctgttagcc 1702261 tcctttctta tccccctgtt ttcagtgcgt ccttgttata cattgtctga atattaagag 1702321 ttttttcacc cttccacttt ttgagggctt tattcagtat cgtcacgtga tgatcctcca 1702381 cttcaaatgt tgctccagcg agatgcggtg ttgccagaac attaggcaat gaaatcaatt 1702441 cataatctga ttcctctgga ggttcatgat aaaaaacgtc tagtatcgca ccgctgattt 1702501 tatgttcttt taatacaaat aaaagatctt cacggtttac aacaactgct cttgaagtat 1702561 taacgaaaat cgcactctct ttcatcagat caaaatattg ccgatctatc agtccgagtg 1702621 tttcctcagt gcgaggcaga tggacagaaa cgatatcgct gtctgaaaac accgttttaa 1702681 gagatgcttt ttcatacaac ggatgatcgt cttgaatgta tggatcgtaa tattttatct 1702741 tacagtcaaa cgcagtcagc agttttgcaa tcctttgccc gactgcgccg aacccaatca 1702801 tgccaaccgt ttttcctgtt agctcatttc ctttaaattt gacataagcc tgcaggtaat 1702861 cactgtccca ctctccatcc ttcagccact gattcgaggc gctggtatgg cgcagaaagg 1702921 aaatcacatt tccaataaac atttcggcaa cggcttgtgc attccgccct ggtgtataaa 1702981 aaacaggtat gccccttttt gaggcagctg ccacatccac atttgagggc attcccctgc 1703041 aaacaccgac aaatgaaagt tcgggaacag aagcaaatac gctgtctgtt acctgatcaa 1703101 gttcagtaat caagcctgtc gcatttgttg cttttagcag ctgaatgagt tcatcctccc 1703161 gatatgccct accttgttcc ttccaagatt gataagcaac tgagccaaac aagttttcaa 1703221 gctcttttcg tccttcttcg ttgtacggtg ctgtaaccaa aaccgtcatg ctgcaaaaca 1703281 tccttttcat cgtatttttc ataaaaaaaa tctctttccg aagatggaaa gagattcata 1703341 tataggcgcg ctctgttaca ggcagacgcc ggtataaacc ttgctttcct atctttcaag 1703401 ctagcgcttg ctggaattgg cacaataatg ttgccgaggt ttcatagggc cagtccctcc 1703461 acctctctgg atagaaaata ttgagtatgt aattttcaga atgaagaata cgtttatcat 1703521 aaagaagact cagattgatg tcaatctctt tttttcagaa ttgacgttat catcggaaat 1703581 gttataattc ttacaaaata tctaactaga gagaggaact gggccatgag atcttttgcc 1703641 acacaacaaa acggcatttt caaatccgtt tgctcgctgg actgcccgga tcagtgcgga 1703701 ttgttaatac ataaaaaaga cgggaaaatc gtaaaagtgc aaggagaccc tgatcatcct 1703761 gtcacagctg gaaacatatg caacaaagtc cggaatatga cggagcgcat ctatgatgaa 1703821 aagcggctga ctacaccgct caaacgaaca ggtgcgaaag gccaagcgat atttgaaccg 1703881 atttcctgga aagaggcaat cgatacgatc acctcccgct ggaaacagct gattgatgaa 1703941 gagggagctg aaagcatact tccttacagc ttttacggaa atatggggaa attgacagct 1704001 gaaggaatgg accgccgctt tttttaccgc atggggtcaa gccagcttga acggacgatt 1704061 tgcagcaaag cgggatctga aggctataaa tatacaatgg gcataagcgc gggaatcgat 1704121 cctgaggaaa ccgttcatac aaaactattt attttttggg gaatcaacgc ggtcagcaca 1704181 aatatgcacc aaattacgat cgcccaaaaa gcgcgaaaaa aaggtgccaa aattgtcgtg 1704241 atcgatgtgc ataaaaatca aacaggacgt cttgcagatt ggtttatccc aataaaaccg 1704301 ggaaccgaca gtgcacttgc tcttggcatc atgcacattt tatttaaaga aaaccttcat 1704361 gatgaagcat ttctgtccga gtacacggtt ggctatgaag agctccgtga acacgtgaaa 1704421 caatatgatc ctgaaaaggt atcgacgatc accggtgtca gtaccgaaga tatttaccga 1704481 ctggcaaaaa tgtacgggga aacctcccct tcttttatca gaatcggaaa cggaccccag 1704541 catcacgata acggggggat gattgtaagg acgattgcct gtcttccggc gatcaccggc 1704601 caatggctgc acacaggggg cggcgcaatt aagcataaca gcggaatttt agaatataac 1704661 acaaatgcct tgcagcggcc cgacttattg aaagggcgca ccccgaggtc gtttaatatg 1704721 aatcagcttg gcagggtgct tttggaaaca gacccgccga ttcgctctct atttatttac 1704781 ggaacgaacc ctgccgtcgt cgcgcccgaa gcaaacaaag tcagacaggg cttgctgcgg 1704841 gaagacttgt ttactgtggt tcatgatttg tttttaacgg aaacggctgc atatgcggac 1704901 attgtactgc ctgcaacatc cgcttttgaa aatactgatt tttacacctc ctactggcac 1704961 cattacattc agcttcagca gccggtgatt gagagatatg gggaaagcaa gtctaacact 1705021 gaggttttcc gattactggc tgaagccatg ggattcacag accaggagct taaagattca 1705081 gatgaagtat taatccgcca ggcgcttgac catccagata atccgcattt ggcagagatt 1705141 gattacgatt cacttactaa gcattcattt atgaaagcga aacgtgaaaa gccgctgttt 1705201 ccgggcgaac ttccaacgcc aagcggaaaa atagaattat attcagaaaa aatgaaacaa 1705261 gacggcttcc ctgctttacc gacatataca cctcttgtaa ccgataatga acatccgttt 1705321 atgtatgttc cggggccaaa ccataatttc ttaaactcaa cattttccaa taatgaaaaa 1705381 cacatcaagc ttgaaaagac gccaaagctc tttatcaaca caaaagatgc tgaaaaacac 1705441 ggaatcgttg atggggcacc tgtacgaatt tggaacagcc ggggagaatg cgagctgacc 1705501 gctgcagttg gagaacaagt gctgccaggt gtcgttgtca gccaaggatt atgggcggat 1705561 gaacaaggaa aaaaacagct tgtaaacgcg ctaaccccag atcgcttgtc cgatatgggc 1705621 ggcggcgcca cctttttttc aggccgtgta cagattgaaa aggtttgaaa aataatgaaa 1705681 cccggagtat gccaagcccg tataacataa catcgacata atggaggcat acacatggac 1705741 gtttttttag gaattggtat tgctttggct ggatatttta tcggtgaagg cttaaagcag 1705801 aggaaccaaa ccaaaggtaa tgaacaaaat gatatcttcc taataaaaga acgggatatt 1705861 tacttttaca ttggactttt tttaggaata acaacgactg aagcaaaaca gttagctgga 1705921 gacatggcag acctgcctta catcgaaata aacggaaaaa aatatgtcca gaaacatatg 1705981 ttaaaagatt ggacattcac attagttgaa aaacatcagg gtgaataaaa caaatctgag 1706041 gagagcgaga ttcattgtca cgctctcctc tgtttagctg tatggatcct gccaccaaaa 1706101 ctttgtgcta taagcgctga taaaacgata aaccaccatc tatgttcttt cctcaaacaa 1706161 ctcaagatgc ccgttccaca acaatagttt ttatattcct ttgatgacgt gatgttcttg 1706221 atgaacgtat gtatcgtaaa acacttagaa aacctattcg gtttgaatgt gtgctctcat 1706281 tatgccccca tactgcgcct ttatccgcgg aggatttttt taaaaaaata tgaaacctaa 1706341 agcttttaga tcctgaattt ttattgaacc tccatatttc tccgattggt aaaaattagc 1706401 ctatacaccg gaagctgtac gtttataaag gatcagagaa tcccataacc agtaaatcac 1706461 tgcagccgca atacttaaca tataataaaa gtacgattgc aatgtccatg ctattgacgc 1706521 aggttcattg ataacaaaaa acaggaaagc tgcgataaaa gcaaccacac tgtaaatcaa 1706581 taggtacatg acattgaaag ttctcgcttt tttctgcaac ttcatttgga gcggaacagc 1706641 aaaaaggcca tacaccacaa aaccgtataa taaagcaatt gctgccgtaa acaatgcaat 1706701 tatcatatcg ccatacataa cgaaagaata aaaccctaat aacaaaccaa atgtaaggct 1706761 ggatagccct aatgtcatta aataatatga tgcgattttt ttcatttttt cacccccctt 1706821 gtttgattta ttcacagtgc tgttagtata aattcacaac ctttgtattt cttttatcga 1706881 gatgtcttcc ctaacgtgct atacgcaatg cgctaataaa aggtttcaaa aatgacgttc 1706941 ttttattaga taatacgctg gctgaaaacg cctctcctga ttggccaaag cgcgaatgaa 1707001 aaaagtgcat gaatacctgc ccaacagaca gaataagaag agttgatatt tcaacacttt 1707061 tcgtaaaggg gtgaaaccaa tgagtaagaa aggtattcaa aattcaagta ttgaacaaat 1707121 aagaaatgac catgagactg aaacagcttt taaagcagat gatcctaaaa aacacggttc 1707181 cgatcctaaa agaacgaaat aagttcttac ccccactaaa atatcaataa tctggaggaa 1707241 gtaaagtgac tcaaaaaaac ggtgcagaca gacctgatga ttataaaaga ttttcttcat 1707301 tagacaagga atatgatttt cagcaatcta tacgcagcaa tactgagaca gaaagtgtaa 1707361 acactgaaac acaaactcat aacaaagaaa acaaaaatga cacaacagat gttgccggga 1707421 aatactttga gccctcagat tataaaggaa gcacgcaatt agaaaaagga ttggctgaaa 1707481 ctcatgaaca ggtcagcgat gactattttg aagggacaat cgatcaaaat ttggactagc 1707541 catacaaacg gaactaactt aaaagaagtc agttaactct gtttttagaa acaaccacag 1707601 taaaagtagc caacccccac cgaataagat gggggttgca cgtaagtagc ctgtttaata 1707661 tttaaaacga ttaatgacgg tttgaagttc ttctgccaac tgagatagag attctgcggc 1707721 ataggagatt tcccccattg aatgaagctg ttcctgtgat gaatttgcaa ccgcttctgt 1707781 atttgctgac gtttcttttg taccagcagc caatgtatga actgtgtgct gaatcacttc 1707841 aacgcctgaa gtaagctgtt gagttgctgc tgcaacttct tgtatttgag aagtgacctg 1707901 ttccaccagg ttcagtattt cattgaaatt tcctgttgtc tcttgagaaa gaacaatacc 1707961 tgagctcaca ttttcttgaa caactttaat attatttacc gtttctatcg attcgttttg 1708021 gatggtcgct accaccgatt ggatgtggtt tgcagattta tttgtttcat ccgccaactt 1708081 ccgaacttct tctgccacca cagcaaatcc ttttccttgc tctccggctc tggccgcctc 1708141 gatcgctgca tttagtgcca acaaatttgt ctgctctgaa atcgtcgtga taagcgaaga 1708201 gatatcgctg atttctgctg tgctcgctac caatgtttgc aatccattgc cggctgaatc 1708261 tacagattta tcaatgaatt tcatctggtc taacatcttg ttgacggact tagagcctat 1708321 ttcagccttg tctctcatcg aagaagaaag atccgctatg ttccctgtat ttgaagcgac 1708381 tgatgatata ctgtctaata attcagtgat ggattctgcg ctcttttctg tcattgagct 1708441 ttgcttcaca ttgctgtcgg cagccatctg catggctcgt gaaatatgtt cagatgttga 1708501 tttcgattct tccgcgcttg ccgataattc ttcagaggaa gcggcgactt gttcagatga 1708561 gctgctgatc tgcttcacaa tttgagttaa tgaatgagta aaagaattaa aagattgggc 1708621 aagctggcca aattcatctt tatttttcac aatgactttt ttggttaaat cagcctcgcc 1708681 gtgtgcaatt tcctccagct gcttatttat gcttcttagt ggcaccataa tggactttaa 1708741 cagcattatg cttagaacaa tgcctaatat tactgatatc cctgtgacaa tgataatgag 1708801 cgattgactc attttcccat tgccctgtat ttcatccttt agatcctcta cctcttgatc 1708861 caggcgatca gacagcttat tgacagccgg agctacgcct tcttttctta ttgttctttc 1708921 ttctccaaaa tggatggttt ctgctttttt aggatttgaa gagtaggctg ttactacttg 1708981 ctgattcaaa gctctatact gagtaaaact tgtcttaatg tcttcaatat tggattgata 1709041 cttctcttca tcaatcaagt cattaacccg gtcaaggctc tttaagacat cgtctgcttt 1709101 tcccttcata ccctcgtcgt attctttgtc tctggtaatc aagaagcctc tttcatcatt 1709161 tgataacccg gtcaattcat attggatgtg ttttatctct ttttggaatt ccattttgtc 1709221 tttaagttct tcattctttt tcacagtaga agaaatcata aatactgagg agcctccaat 1709281 tccaataatt gaaacaacta atattgatat aatccccagc aattttgttt tcactttcat 1709341 gtgtcgtttt ccctttccgc acaatgtaat ggctgaaata aaatatgttc aagcgcgttt 1709401 gaatccaatt cgcttacgct catgtccata atatcgacac gtgttatcaa gttttatagt 1709461 gatattctta tatgaataag caaattcttt acgtctctga acttacagaa aaaccttaag 1709521 taaaatttgc agtcttttgc ggtatgtaag tcactcttat tcgtttttct aaaaaaggct 1709581 tttcccacct caaattggct gaaccggctg ttttctcgaa aatataatac aatacgcagc 1709641 ataatatgaa ggagcgaaac ttaaatgggg atcatcaatg gtaaagaatt cattgaccga 1709701 ttgaataaac tagaaaacga aatatggtat gatggcgaaa aaataaaggg taacatttct 1709761 gagcatcctg catttaaagg aataatcaaa acaaaaagct cactttatga attgcaaaca 1709821 aaggatgagt taatacatga aatgacttat tgccttcctg gagatcataa tcgaatcggc 1709881 ctttcctatc tccagcctaa aacaaaaaat gatttgaaaa aaagaaggac catgattgaa 1709941 cattgggcta gacatactca tggaatgatg gggagaagtc cggattacat gaatacggtt 1710001 atgatgagct ttgcttcgtc agcggagctt ctaaaagata aagagaattg ctttcctgaa 1710061 catatactag atatgtatga acaagctgct aagcatgacc tttcctttac ccatacattc 1710121 attactccgc aagtgaaccg gtcacagtcc tattttgggc taagtgaaaa accgatatct 1710181 gctaaagtca ttgatagaac cgaaaaaggt ttaatgattc atggcgcacg actgcttgcc 1710241 acacaaggcg ggttgaccga tgaaatcttg gttttttcag cgcctaaatt tttctttgaa 1710301 acagatgaag cttatgcttt ttcaatccct tctaatacaa aaggcgtaaa attcatcaca 1710361 agagaatcat ttgtattaag cgactcttcc tttaatcatc ccttaagctc aaggtatgaa 1710421 gaaatggatt caattgtggt ttttgatcat gtgttagtgc cgtggaatcg tgtgtttttt 1710481 tacgataatg tggaagcagc taaagatttt atgacaaaaa gctcttttca tgcctttacc 1710541 tttcaccagg ttgtcattag gcaaatgata aaaattgaat ttctattagg tgttgcacag 1710601 cttcttgtcg acaccattaa tgtttccgaa tatcagcaca tccaagaaaa gctctcagaa 1710661 atcattgtgg gattggaaac aatcaaagcc ctcattgaca aatcggaaaa tgatgctcag 1710721 ttagatgaat tcggctatat gcgcccctgt ttaattcctc ttcaagtcat cagtacgatc 1710781 attcctaagc tatatcctcg atttactgaa atcatacaat taattggagc tagcggaatg 1710841 gtgacactgc ctaccgaaaa tgcatttgac tcagagatac gggaagatct tgaccaatat 1710901 cttcaagcaa ccaatacaaa tgctgaagaa cgtgtgaaaa ttttccgttt ggcatgggat 1710961 ttaacaatga gttcattcgg aactagacaa actcactacg aaagatattt tttcggagat 1711021 cctattcgga tttcaagcag gctgtatacc agttatccaa agcaggagca gttgaacatg 1711081 attaaaacat ttttacatgc agatacagaa cattgaaaaa acagcgggaa aagatccgct 1711141 gtttcgtatt ttttattcag gaaactgaac atggcccggt actgtatagg ctttggacgt 1711201 tccgctttca ggcagctttg gaatggtgtc tttcacaact tttccgcgga tgtcagtcat 1711261 tctgactttg agagagccag tacctaaatt cgtactcaca aaatggttat agtccatttt 1711321 ctccatgttg atccacttac catccttttc atattccatt ttcataacag gatacttgtg 1711381 atttctgact tggattgctg cccaccacct gctgctgcct tctttgatcc ggtacgtgaa 1711441 attgccggtg attggggctt tgacaacacg ccatttaata ttgatttttc cgtctttcat 1711501 attgccgatt ttacggaagg cattaggtga cagatcaaga gctccccgag cgccttcggg 1711561 ataaagatca gtaacatata cggttgtttt cccttttggc ccttcaactt ccaaataaga 1711621 gccggcaagt gccgctttta ctcctccgta attgagatcc gccggattta ttgcagtaat 1711681 ctccatatcg gaaggaatgg gatccagcag gaaagctcct cctgaatagc ctgaccctgt 1711741 atacgttgca taaccttcat gcaggtcgtc atatgctgcc gaagcttgcg gggaaaaaca 1711801 gaagatcgtc aacaaaacca taccaacaaa tgcactcatg atctttttca tatttggtcc 1711861 tcctcaaacc agacttcaaa tgagaatcat tatcattata agactcaatc catctggttt 1711921 gaaagaggaa atagattcat agttgatttt aaggcaaatt cactatcatt catatatcaa 1711981 atgtaggtac ttatgaaaaa gccaatacaa atgaacgaat gtgcacttca gccgaatgtc 1712041 ttatttttcc ctctcaaaat tcgcatttca ataacgaaat gaaacaggct gttggcctga 1712101 taacagctat acaggaaaag ctatttttcc ccgctcagtt tcaacttagc tgtcatcatg 1712161 atgccaaaga tcagcacaat cggaacccaa ataatgaagt gataaaaatc aggctcagcc 1712221 agagcaacaa taatagcccc tacacaatac aaaataatag ccagtgctct taacacagta 1712281 tctcttaaga aagtcttctt ttgcttctta aaaaacaaac ggccggatat atcctctaaa 1712341 agagaagcca aagtgccggt caacacagtt gaagaaatac ctgcaatccc cagttttttt 1712401 gctgctgtag tttgaatccc catagaaatg ctcatgagta taattagaat gtgcacagga 1712461 acaaatgccc ggtaaaaaga aagacaagca aagacaaaca aaatgaatgc ttcaagtgcg 1712521 agggcttttg tcacagcaga aggccaaagg gtattttccg cctttccgac catcaatgta 1712581 gcaatgatca cgccgcatat aaatccgatt agcgcagtca aggaattaaa aacagtgacc 1712641 tgaatggatt tgccgatagc taaccccaat aatacaatgt ttccagtcat attagctgtg 1712701 aacacatgtc ccaggcttaa atacccgatt acatccacga ttccagctgt taaacataaa 1712761 agtgatagca aggtgtttcg ataagctgct gcagtcaacg gtgtatcaat cctttcttct 1712821 atttcaattg ttagtatgtc ttttggcgca atctctattt tttaagtaac ccaacattaa 1712881 ttaggaagat agaacctatt attcctttcc attaactgta ataataatcc ccgcaaggaa 1712941 atgattaaaa ttgaaaggaa gcatattgtg atgaaacgac tttgtttatg gttcaccgtc 1713001 tttagcttgt ttttggttct cttgcctgga aaagcattag gtgcagtcga ttttccgaat 1713061 acctcaacaa atggcctttt aggttttgcc ggaaatgcca aaaatgaaaa aggcatctct 1713121 aaaacgggca caacgggtgg aaaaaacggg cagattgttt acattcaaag cgtaaatgat 1713181 ttaaaaaccc atctaggagg atccactccg aaaattttag tgcttcaaaa tgatctttcc 1713241 gcatctgcga aaacaacagt taccattggc tcaaataaaa cactcgtggg ctcttacgcg 1713301 aaaaaaacgc tgaaaaatat ttatttaaca acttcatcag cttttggaaa tgtcattttt 1713361 caaaatttaa cgtttgaaca cagtccgcag attaacggaa ataatgatat ccagctttat 1713421 ttagattccg gtatgaacta ttggattgat cacgtcacat tctcaggtca tagctataat 1713481 gcaagcggaa gcgatttgga caaactcgtg tatatcggaa aatccgcaga ttatatcacg 1713541 atcagcaact caaaatttgc gaatcataaa tacggtttga ttttaggata cccggatgat 1713601 tctcagcatc aatatgacgg ctacccccac atgacaatcg ccaataatta ttttgagaac 1713661 ttgtatgtta gaggcccagg tctgatgaga tacggttact ttcatgttaa aaacaattac 1713721 agcaataatt ttaaccaggc gattacaatt gctacaaaag caaaaatata ttccgaatat 1713781 aattactttg ggaaaggcag tgaaaaaggc ggcatccttg acgacaaggg cactggttat 1713841 ttcaaagaca taggcagcta tccatcactc aacaagcaaa cctctccgct gacttcttgg 1713901 aatcctgggt caaactatag ctatcgtgtc caaacgccgg aatatacaaa agaatttgtc 1713961 acgaaatatg ccggatcaca aagtacaact ctggtatttg gctactgata taaaagaggc 1714021 cctgcgttaa aaacgctgtg cctcttttta tactataggc tatttttaag cgatccttgt 1714081 aattccatca agatccagcg tcggtcaaac taaaaagcat atgttctttt ccacaataac 1714141 ttcttaactg gctttcttat tataccagtt tatcgcaagt gaaaagaaat cattgttctg 1714201 aacctgtatt aaatgaacga tcgtcccaca aactacttaa aaacccctaa aaaggatgat 1714261 ggatatgtgc ggcaggttta ctttgtactc tgcatttgat gatattattg accagtttga 1714321 catcgatcaa ttttttccta aaggtgaata ccagccaagc tataatgtcg caccatcaca 1714381 aaacatcctt gcaatcatca atgatggatc aaataatcgc ttaggcaagc ttagatgggg 1714441 acttattcca ccttgggcaa aagatgaaaa gatcggttat aaaatgatca atgctcgagc 1714501 cgaaacaatt accgagaaac cggcctttcg aagaccgctt gtcagcaaac gctgcatcat 1714561 accagcagac agtttttatg aatggaaacg gcttgattcc aaaaccaaaa tcccaatgcg 1714621 gatcaaattg aaatcatctg ctctttttgc gtttgctggc ttatatgaaa agtggagcac 1714681 acatcaagga taccctcttt atacctgcac catcataaca actgagccta atgagttcat 1714741 gaaagatata cacgaccgaa tgccggttat attggcccat gatcatgaaa aggagtggct 1714801 taaccccaaa aatacaagcc ctgattatct gcaaagtttg ctgctgcctt atgatgctga 1714861 tgacatggaa gcataccagg tttcatcatt agtaaattca cccaaaaata attcagctga 1714921 gcttcttgat gcagaaaatc atatgtagtg attgaaaaaa ttctctagca agaacttgtc 1714981 aaatagcttt gttccttagg tgccaatccc tctagtaatt atgaatattt agtacataga 1715041 tcaattagtt atctttagca tcagtttgaa ataattttat tatgtaaact taaataagca 1715101 atgttattcc tttcatataa aatagtttac atttttataa aatcgcttca cttttctatt 1715161 ttgtcagcaa aaaaactgaa ccacattaaa cttatgaaac ctgccgcacc tgtggattgc 1715221 aaatatgata taagcccata gaggtaaatc catacacttt ccctcctaag aattaaatga 1715281 aatttctttc atcttacatg aaggtcttct ttcttttgtt tatccagtgt aatacttaat 1715341 aatatgttga tgaatgcagc tggaaaatat ataaatccca ctccaagaat gcctagtatc 1715401 gtacttaaac ttactatgta attctttgtc atcgtttgac tgtcaatcaa tattagaagt 1715461 gaaatcaatc cagctaaaac acctataaac caagcatcgc caacagcata agaatcatcc 1715521 agcatcccta accatcgccc caatatagag ctcccaatgg cagtcaaact ggataaaaat 1715581 atgagtgctt tcatttcttc tcctccttta aagccaatca aactggtaga aatcggccat 1715641 tgaatcccca ttatcgaatg gttaccattt catttccaca ttaacatttt aaagctcatt 1715701 acaatacgat tcaagcagaa aaaccctaca taacgtatat atagggattt aataaaacac 1715761 aggccaaaat tcagctctat ctactttaaa aagatatgaa gggcagctgt gtgatctgtt 1715821 acgtctttac gtaccgggat atttcacaac aggcactttc ttcttgcgca gagaatcaag 1715881 catgactgat ccagcattca agttgctttg tactaattct ttaggcgtca atgccatcca 1715941 ctgattgagt gacacatctg catagcggtt acttttgaac atttctaaaa accataatgt 1716001 ttctgtacca gtgttttgta tatagtgtcc ggcattagaa ggcacgtatc caacgtcgcc 1716061 tgctctataa tcaaatgtgc gggcagtccc atttccgata aataccgtca ttcgtccctg 1716121 tcctgttaga taatattgcc actcatcgct attgggatgc caatgaagct ctctcatcgc 1716181 gccaggctca atctgaacaa gtgcagcggc tatcgttttt gaaattggga agttagaaga 1716241 atccacaatt cgtacactcc cccctggcat ttgaattggg ggttgattta acagctcgtg 1716301 tttaaaggtc atggggactt ttccatatgg tgactgaatg tcttcactgg cgactgatcc 1716361 cggcacattc ccttggtaga tatagacttg ctcagacgga agagagttga aagcattctc 1716421 cgggacaccg aaatttgcag acagaacatc ttttggtgtg tgtgcaagcc aatctgaaat 1716481 ggttaacgtt gaaaactcag aaaagttccc atcatcgaaa acgagcagaa actcgcagtg 1716541 ttccaatccc tgtatggaat gcggaattcc tgccgggaag taccaaaggt cgccgggacc 1716601 aacatcagca atgaaatttc gtccgtcttg gtcaacagcg gtgatacgtg cccgtcccaa 1716661 aagcatataa gcccactccg cttgcttatg ccaatgaagc tcgcggacgc ctcccgcagt 1716721 taagctcatg tttacacctg caatcgcagt cgaaatcgga agctgtctta cggtgatttc 1716781 tcttgaccag ccgccgtgat ctaatttcat gggagcgtct gagaatgaaa atctcaagtt 1716841 aggaatcata ccctcatctg taacaggcgg aacaaatata ttcggatttt gaatatcccg 1716901 tattatattt cgcgggcctg tatcaatagc tccagctcca tcacttcgaa taggctgcgg 1716961 cacgtttctg tcttcatgat tgattggttg ttgttccaac agcatgcacc tcgttttaga 1717021 aatgaacaag attttatttc agcctatgca gaatcttaga ttgctgtgcc taggaatccg 1717081 caaataaaaa agtgaccacc aatgtgatca caaatacatc aaataaacta ttttttatac 1717141 catggcttct tatgtaattt gattgcttct gtctgttttt tctggcctgt cctccactcc 1717201 acttttacta atacatcatg acctatcact tcatcttcag gcatataatc aaaggtggaa 1717261 atatggtcct ccatgcgtcc cccacccggc atttcatcac ctgtgtactc cgataagtcg 1717321 tactcatcta cgttatcatc ttgatacttt tcgccatcta catacagagt aattctttca 1717381 acaacagtcc acttttcttc cttcttactc ccctgccaat atagatttag aaaataattg 1717441 ggtccaattg aagttttgtc tgatttttca aggttagaca tccacagtcc gcttttcccg 1717501 ctgccctcat atttcacttt gttccctgac accattacaa ataatgtgat gatgcagatg 1717561 atcaagaatc cagcaatgat caatagccat ttcttaatat tgttcttttt tctcatgttt 1717621 ttcctcactt tcctaacttt ttagtaggaa aatacgatca aaatgttacc gaaaagaaaa 1717681 taagaaaggg ctaatgatct aacagatgac tgtctaaact tttgacttaa attaaagtgc 1717741 tttctaaaga caagattaaa acgtataaca gctcttaaat gcattttttg tttcattgag 1717801 tcaagaacct taaaatggct ttttattatt aaaaatcaag ctagtgtatt aagtaacttt 1717861 tcaaatttat ttatactcat gatctcgtga gtcacaaatc tcccatcaaa aaaaacgcta 1717921 aaagttgtcc aaatagctgg tgacttttgt gcctcttctt tcgatgataa ctgaattgac 1717981 tgaaattgaa cccctttctt ttcagtcaat tcccgcaaat catttatcat gcccactgca 1718041 aacggacact gagctgtata gtatatcgta atcccctttt cattgataga atcacttttc 1718101 acctggctct taaatgcagg agaatctgca aggccattcc aagtcaaagc cattaattga 1718161 aaataagggg cagcttcatc ttgtagagta aaccccatat gctcaaagaa atgcttatca 1718221 cttaaatagg gcagtttttt cttgcctgcg atatggataa tgccatccat gccgcacgct 1718281 ttcgcatctg ctatacattt gtccaacaat cgtttcgcat gaccgttatt tttatatctg 1718341 ccagacaccc acagacaatt aatgtacata aaattaggcg cattgatagg cacccatgcc 1718401 tcattcgcag gtaggtattc aataaagact tttgcccgtt catgtaagcg atagaacacc 1718461 aatccttcat ccattcgagc tttgagccat ctcttctttt cattaactgc atgctcatat 1718521 tgtttcgtgc ttaatgcaca gcaaatatga ttgtcttcaa tattgtcctt tgtgatttca 1718581 atgtagcaca tctcctcttt ccccccttta acataattac atggaattca acttcacact 1718641 ttacatgcct aatagaataa atacccgttc caacttaaat actttttctt ttccattttg 1718701 ccaattaact gtaaaaccct tcttttattc agatattatc ttgattccta tatcacccat 1718761 ttcaaatcca aagtgtgttc atctttgagg attagatgca ctgcttatgc tataaataca 1718821 gtacacgaag ttttttattt gaagtaatat ttgttacggg acagcaatag taaataagtg 1718881 ataaaagggg aattaaactt ggtggaaaaa tgttattctt gtttaatttg cggatacaaa 1718941 ggattaattc aaaatccttt gtataaaggc gagtatcaaa aaacgtttga catttgtcca 1719001 tgttgcggtt ttgaatttgg ctacagtgag gatcatgatg tgaggttagg ttttattgta 1719061 actcctgatc atttaattga ggctgcattt caattgtatc gcaaacaatg gcttgagagc 1719121 gggatggtaa ttgctcatcc ggaagatatt ccagaagaat tgaaaaatgg caattgctta 1719181 aaatttgaag ttttgttgaa acaattgaaa aaactaaatc ttgacataga aaattttgaa 1719241 attagcggtt tttaatgatg aaacaggttg cacttgttta ggtttcactg tcattatcag 1719301 taaaatgtta agttgaaatg cgcaatcagt cacaaagtct ctattcgtat tcaataaaga 1719361 ctttgtgatc atcgacaaac atttcactcc catcggataa agtatccaaa aggcctcctc 1719421 tggttcttct ctatagtcat taatcacagt cactttgaca tttgactcag ctatgattgg 1719481 ttttccaaca atttttcgtt ttttcctcag gcaaagtaag agatcgaatc atcaaagcca 1719541 ttccatcttt actgtctaat taacgccatc ttcagtgaat ttaaaggtct gttttaaatt 1719601 gcgtccttct tgccccttct gtgtccaaat tataacaacc tctaattcag aggccttatc 1719661 tgccagcata aaatgattga acttcagcgg tgagccatca tttaaacttt cagctaacat 1719721 tttagaatct tcttttggtt tgacacaatt ttcatcggga catccaaaaa gcgaaaacct 1719781 tgtgattgaa ttagggtcat ttctatacaa ttgcacatcc actgtagctg ctttttcccc 1719841 tatatttttg acttccaagg aatatacttg atattctcct ttatgaggtc tcgtaaattc 1719901 ctttacattt tttgcttcac ttacttttac tgaccactgg tctgtttttt gtgtaatagg 1719961 caacaccgta aaagtcaggg catgcgcttt tgattggcaa aacgtaaatc caactgctgt 1720021 aaaaacaatt acagaaaata ataccctttt cacttcattt atccctcctt cctttcactg 1720081 gccgctcctt aaagaattga ttttgagcaa tctacaagct ctcttaacca aaaccttacc 1720141 tgaggttttg tctttactgc tctgcattta tttctttcgg tatccgagaa ggagctttgg 1720201 ggatttttct caatctgctg ttaatcacat cagaagagta tagcgtaata atcatacttc 1720261 ccccatacct ttttgcccga attaagattg gttggttata ttggttttga aagcgaaagt 1720321 caggacctcc ccagcttacc gtcgcatccc gtccgggcgg tacatatggt acacttctag 1720381 tatgagaata gcgctgaacg atctgcagtc ctgcacgatc tactgcatta aatagagttg 1720441 aggacacctg acaaattcct cctcctacac cttcagacaa ctcccctttt acaataatgg 1720501 gtgcactttt atatcctttg ttccgagttc tcattcccac aacttggtta aacgaaaacg 1720561 tctcattagg gaaaacaacg tgattgtcga ttgcttttgc agaaagagaa atattgtgtg 1720621 aacggctttt attgcttgag ttaaaatacg tcacgtactg accaagctgc tgcgtactga 1720681 tgtgagctag cagctcgctg tcaactttcg gataaatgtt catttccggc acttctatct 1720741 tggagggacc ttgcccataa aaatacgcat aaaacttttc cataaacgcc tgttgataca 1720801 gtttgtagcc aaccctgccc gggacgatgc ttccatgatc gttaaggaca gcatttatcg 1720861 gctcacggta cactttctga tcaagctgtt tgatgaattt actgtatttt tcatagtcaa 1720921 ccattggagt gccgggaaga ggcattgtaa agtcttcacg gttaacagtg gcaatcgtcc 1720981 gtccttgctg tgtgaccgtt aaactgtcct gcggctcact cggctgagcc aataaaaaaa 1721041 gaccagtgat caaaatttgt atcataagtc ggtttacctc ccaatcatta gtatgaacag 1721101 ccgcttatcc tttgatgtat ttcttcccat cgtttgtttg aatctttaga cgttgataaa 1721161 aaccttcata aaagagctta gctttatgtt cacaccgatc cctgagctca ctgaggcaca 1721221 cggttcattc agtcggcaag tttgaagtag ttcagcatct cccagtgatg agggatgctt 1721281 ttttgtcttg tcaaaaatga aaagggtctc ctataacaac aaaaaatcaa tccatttcaa 1721341 tattttttta ttgagaaacg ataaattttt tgttacattc aattagacaa caaataaatg 1721401 aggtgcttgt tatgaatcga atgtcgacaa tttttttaaa gatagctttg gttcttattg 1721461 gaattccaat tcttgcttta tgcatttttt tagtgcctaa ggtagccaac tattcagcag 1721521 aattatttcc aaatatcgct tatataaaat atctcgtttt catctatttg tatgtaacgg 1721581 cgataccttt ttactttgct ctttatcaag cgttcaaact tttaagctat attgacaaaa 1721641 acaaagcttt ctcgggtttg tctgtaagag ctttgaagaa tataaaatat tgcgcagtca 1721701 ctatcagtat cttttacgca gcaggcatgc ctgtctttta tctgatggcc gagatagacg 1721761 acgccccggg tatcattgtg atcggattgg ttattatttt tgcttcaatg gtgattgcgg 1721821 tctttgctgc tgttcttcaa aaactgttaa aagaagcgat tgatataaaa tcagaaaatg 1721881 acttaacggt ctgaggtgat gacatggcga ttattatcaa cattgatgtg atgcttgcta 1721941 agaggaaaat gagcgtaaca gagctttcag agagagttgg catcaccatg gctaatcttt 1722001 cgatattaaa aaacggaaaa gcaaaggcta ttcgattatc aactttagaa gcgatttgca 1722061 aggctttaga atgtcagccc ggggatatat tggaataccg aagtgatgaa gacacaggat 1722121 tcgtaaagaa aaaatatgaa ggatcaacag aaaaataaag tgattggcgg tgagcttatg 1722181 gacataaact tatatccatc tagctgctat actaagcgtc cctttcatac acgaagaaca 1722241 caactatgga ggaggcatac atcatgagag ccataaaaca aatcgtccat tttggctggg 1722301 aacaagccct ttcatgtttg tttcctgccg ttatttttgc ctctttggct attacgcaaa 1722361 tcatcccact gcccttcttg ccgcggtatg actggctgct cattatctgc gttctcatgc 1722421 aattgtggat ggtgcgttcc ggtcttgaga cacgggatga attaaaagtg atcacattat 1722481 tccaccttat tgggcttgct ctggaacttt ttaaagtcca tatgggctcc tggtcttatc 1722541 cagaagaagg atactccaaa atatttggag tacctttgta tagcggcttt atgtacgcaa 1722601 gtgtagccag ttatttgtgc caggcatgga gaaggcttaa ggttgaactg gttaagtggc 1722661 cgtctttttt tgcagttgtt ccgcttgccg cagcgattta tttgaatttt ttcacccacc 1722721 atttttctat agacattcga tggtggttat cagggcttgt catcattgtc ttttggcaaa 1722781 catgggttac atacgaggtg aatggagctc gttaccgtat gccgctcgca ctttctttta 1722841 tactcatcgg attttttata tggatagcgg aaaatatcgc tacgtttttt ggagcttgga 1722901 aatatccaaa ccaaatcgat acatggagtc tcgtacacct tggaaaggta agttcatggc 1722961 tcttgctagt gattgttagc tttcttatag tagcatcatt aaaacaagtt aaggagcaga 1723021 gtcccacaaa ggcagagatg gatgaatctt tttcttagca tacgcataca agctcccaaa 1723081 tagagtgaaa agcaacgttc aaatggttgc ttttttcttt tatgtaactc tgccggtgag 1723141 tattcatctt cttcaaattt catcgcaaca cgataactga ttcagattac aactgctttc 1723201 aacactttga caaactcatg cgccgccggc gttatctctt caaatgaatg tgcgatgacg 1723261 ccaatatcgc gtgtgaccct aggaaagatg tcctttttaa tcaattgatg cgggacggat 1723321 gaaagtgtaa agtttgaaat gatgccgata cccaagttat ttttgaccat attaatcaag 1723381 gtttcggcat tttgcacagt taagttttcc tttaattcga tgttgtattg cgaaaatgcg 1723441 tttgacatcg cgatttcatg accgccttta caaaaaatga ggtcatcttg atatgtttca 1723501 aggtcgacat gcttttcaag ttttaattcg tcacgctgcg gcgggatgac ggccaccata 1723561 tagtcgttac acaatagctg attttcaaac ggttcaaatg gagatgctgc gatcccgata 1723621 tcaaccgtcc gatcttcaac ccatcctttt atttggtcag aggttccttc gatcaattct 1723681 atgcggatca gcgggtagtt tgatctgaat gccgcaatcg cctgtggcat gatatttgtt 1723741 gaaactgcag gaaatgaacc aattttcacc ttcccgttta acagcttgtt ttcccggttg 1723801 gctacttgat atattttgct ttcaattccc ttcatttgcc tcgccagcag caatatttct 1723861 tttccgatgt cagtcagcat taaaccatga tgtttatccc tgatcaataa tttgagctgc 1723921 agtgagctct ccaggttttt tatcgcttta cttaccgccg gctgagagat gaacaattct 1723981 tttgccgctt ctgtaatatt taatttctcc ccaactttta caaatatgtg aagatggttc 1724041 atgttcataa ccatttggtt atacccccaa taataaaaat gtatttcagt tatacataaa 1724101 tgtaacatat gatagaaacc agcacgatat tttaacaaga aaggcggctt cattatggta 1724161 aaagttatgc tgggaatcat atctgtcaca cttatttggg gttatacttg ggttgcgatg 1724221 aaagtaggaa ttcatgacat ccccccgctt ttattttcgg gtttgcgcct gttcatcgga 1724281 gcagttcctt tatttctcat tctcttcatc caaagaaaaa agctttcaat tcaaaaagaa 1724341 catctcaaaa gctatatcat catgagcctg ttgatggggc tgggctatat ggggattttg 1724401 acgtatggaa tgcagtttgt cgattcaggg aaaacctctg ttttggtata tacaatgcct 1724461 atatttgtta cggtgatcag ccatttttca ttaaacgaga aaatgaatgt gtataaaacg 1724521 atgggactgg tctgcggcct cttcggactg ttatttatat ttggaaagga aatgctcaat 1724581 atcgatcaaa gcgctttatt tggggagctg tgcgtacttg tggcagcgct tagctgggga 1724641 atcgcgaatg tgttcagcaa gctacaattc aagcatatcg atattattca catgaatgcc 1724701 tggcacctta tgatgggagc cgtcatgtta ttggtgtttt cctttatatt tgaggcggtc 1724761 ccttcagccg agtggacata tcaggcggtg tggtcattgc tgtttaatgg cttgctttcc 1724821 accggcttta cctttgtcgt atggttttgg gtgctcaatc aaatccaagc gtcaaaagca 1724881 tccatggcat taatgtttgt tcccgtattg gccctattct ttggatggct gcaattgcac 1724941 gaacagatca ccatcaatat tatcctcggc gcactgctga tatgctgcgg gatttttatg 1725001 aatacattta cattttcacg acggaaagtg tgaatgatat acatttcccc tgtcatttgg 1725061 gcttcatgtg acaggagaag actattacga gaaagtcttc tagaatcctg acgacagcct 1725121 attaaacaat gaaaaaagct aatgtctgca tgtagacatt agcttggctg gcgtttaggc 1725181 tggtgagaat ccagatactt ttttattacc attctggctg atcaaactga aaaccgtata 1725241 gaccttttac tttaacatct ccgcaatctg gatcttttgt caaaatcaaa taatgagtct 1725301 tataaggcat cgtctcaact cgatcagttg cactaaaatc aaaatgatcc cccgagaagt 1725361 ttttttcact aacggttatt tcatatcctg acaaagtcat tcgcatgatt cttgcgttaa 1725421 ttgtacatcc ttcagtatcg aaaatggtga atctgtaccc aaagtgagat gtccaatggt 1725481 ttgaatttag gtcatcagac ttcataaacc atttttcatt ctctgtcatt gtaaaactca 1725541 ctttctcctc atctttcacg ataacggccg aagcttcccc tacatggata gtcaaagcca 1725601 aaagaaatgt aaaagctaac atcaacatct ttttcaaaag agttcctccc gatatctttt 1725661 acttcaatat attggaaggg tcttttctga tcaagacagt cttctccaaa tgaatcttta 1725721 gcaccatgaa atgagcctta ataagaacag ttttaaccca aatcaacctc tattcgaaat 1725781 aaggcttacc aatctatatt ctttttaaaa gtttctgcat ttctttattt agctcctaga 1725841 cacatataaa aaatgctcct ataagttcag gagcactaca aaaaactgct aaagtgtttt 1725901 ctatcgattt attgtattca ttagctcaaa gaaatattca ggcttttgag tcttatttag 1725961 cttataccat gaacgcaatg tatctggtgc aaatacatct aattttttca atacttctac 1726021 cgcaaattcc agaggagcaa ttcctgatgc agtaaccaaa ttttcatcag atactgcagg 1726081 ccccttttca tagaatgttt ctcctttgta attagggcag accatattca tatagtcgag 1726141 gtcattgctt gtgtgctttc tcgaatttaa gtatccttca ttcgcgaggc ccaaggttgc 1726201 cccacaaatt gcagcaatag tcgtgccgag ctttaaagcg tcgccaactt ttttcaagat 1726261 cggctgatga atatcttctc cccaagtgtt tcctccgggt aaaatgataa gatcttgact 1726321 cccaagagta cattcgtcaa gagaaatatc tggttttatg cttaatcctc ccaacgtagt 1726381 tatcatttct ttattaaccc ctactgtaac tacttttaaa gatgctgcat cttgtttaaa 1726441 gtatctccct gagtttagtt ccgcaattaa atatccatat tcccagtctg acattgtgtg 1726501 aaatacgtag agataaactt ttctcgtttg catccaataa cactccaatc acaattgata 1726561 aagctttcta atagatgact ttgctgacag tcattgtcag cttttttgtt gattctattc 1726621 ttatgccctt gttctcccaa cttataaaaa tataagatca attgattcta tgtttactag 1726681 cgcaaagggg tttgttacac taactgtcat gggaaacatt tcaaaggtaa tacaaaatca 1726741 tttgaatgag gaggcctgat gaagttgaaa actaaagcgt caataaaatt cggaatatgt 1726801 gttgggcttt tatgtttaag cattactggt ttcacacctt ttttcaactc aacacatgcc 1726861 gaagcaaaat ccatagaaga cacaaacatg gcaagctgta taacgaataa aaaatttgtt 1726921 caacttgaga aaaaatttga tgccaggctt ggtgtttatg caattgatat aggttcaaac 1726981 aagacaatcg cctatcggcc gaatgaacga tttgcttacg catcaaccta taaagttcta 1727041 gccgcagctg ctgtcctgaa gaaaaactca attgaaaaac ttaatgaagt catccactac 1727101 agcaaggacg atcttgttac atattctcca atcacagaga aacacctaga tacaggcatg 1727161 agcctaaaag aaatctcgga agcggctatc cgttacagcg ataataccgc tgggaacatc 1727221 ttgttgcaac agcttggcgg ccctaaaggt tttgaaaagt cactgaaaca gattggggat 1727281 catgtaacga aagctaaacg attcgagacg gatctaaact ctgcgattcc tggtgatatt 1727341 cgtgacacca gcaccgcaaa agcactggca accgatctta aagccttcac tttagataac 1727401 actctcacga ctgacaaacg catgatctta accgattgga tgcgaggcaa tgctactggt 1727461 gacgaactga ttcgggcagg cgctccaata ggatgggaag tcggcgataa atccggagcc 1727521 ggaagttacg ggacacgaaa cgacattgct atcgtttggc cgccaaacag agctcctatt 1727581 gttgtggcaa ttctgtcaaa ccgctttacg aaagatgcta attatgataa tgctcttatc 1727641 gctgaggctg caaaagtcgt ccttaacgat ctcaaataat atgtttagcc ttttgccaca 1727701 aaggaaaaga cattactttt ttaacttcta ccgttcattt tttgatgaac ggttctttca 1727761 taagacctct agaatcatat atttaaacac cacaaaatta aacattatta taattaacag 1727821 caagttttca ttttatggaa caagtaaagt ttgaatctga caagaattaa gactaagcac 1727881 cctaaaatcc gttttctttt cttccaagaa tatactcctt agtgcaagcc attataaaga 1727941 tacaagtgaa catacaatgc agacaactct cttaagtctc ttattctgtg accaatttgt 1728001 aatactcatg aatatccgga ctcacttcca atatttcgtc tcgttcgaag acactaacat 1728061 atcaaaccac ttgaattaac ataactgaac ttgatattgg tcactggcag tttcaatgca 1728121 atagaacaac atttgttgtc tcagaggtta tctatatgag aattcaacaa tttttttata 1728181 ataattcata tttttgtatc gttgcacttg gtggatttga ctcttttcgt gtatggaacc 1728241 acacttttat tttttcacct cttttgagat catctgtgtt atcaatctca cttaatccta 1728301 caattactat gttattttta aacttgttca taagttgtcc ttcagaaaga ttgtaatctt 1728361 cttttcctgg agcttttgta tcggtaatga gaattgccct ttcattgtct ttaagcacga 1728421 catagcctac taggctctgc atctttgttt cgtctccgtt ttgttcattt ttattgcagc 1728481 ctgcaaggaa aataatgagc ataatgagca ctatcaagct tactccgatt ttaggcatct 1728541 ttcttcctcc tctttaaact catctttaaa ataaacaaca ggatatcacc caacccatct 1728601 acttcttttt gcaattcata acagcagcat actcattctc caattcctca accttctttt 1728661 tattctttct caaatatttg catgtggtag ccctcgatat tatccgctta ctcatttttg 1728721 cgctttcaaa tatattattg aaggccgctt ctttctggat tccagcataa atatacttat 1728781 ccttactgtc gtttactatc gcaacttcca ttaaaatcga gatttttact ttttttatga 1728841 tccattattc acttccaaaa taacttccaa ttacaacata atatatgtat aaattgtaaa 1728901 tggagttgat gtaattgaag attaggaaaa tcttattgag ttctgcttta tcctttggca 1728961 tgctaatatc cgcggttccc gcattggctg ctggcacttc gtctgaggtt gcagtaaaaa 1729021 atgaagaata tgattatgac actatatacc gcattagtcc tctgccaatg gacttccagc 1729081 caacaataga atacaacggt tatacttata cgcttacacg tcattatttt gattactcaa 1729141 tcgggtttta cacggctatt tatacaaaag ttgtttaaac ttataaagga gctttttagc 1729201 tcctttttct cttgttttaa gcaaggtatt tctttctatg tggtccccta tcaaatacaa 1729261 catcaacatt ctccagttct ctttgacacg aacaaaatct aaagtttggt tttaaatgct 1729321 ggtaataaaa aattcacttt aaagaagtgc cgcccgcaaa atacggcttt tgtacactac 1729381 gccaatttta tattgaaaag ccagacctcc tcaaagaggt tccagctttt cttaatgtgc 1729441 tatcgatctt cgttagttca acgggaactt tatcattcgg tacaaatgca gcctcccaac 1729501 ttctagttag ggctgatggc ggaatatctg acggttctct acacacatca gacattagaa 1729561 gatttcaatg tagccttctg taccatgaac gcgaattcgt tgcccatctt ttatcagctt 1729621 ggcagcattt tcaacgccaa caactgcagg taagccatat tcacgggcta taacagctcc 1729681 atgggtcatc agccccccaa cttcggtgac taggcctttt atggatacaa acaatggtgt 1729741 ccagcttgga tcggtaaagg aggtaactaa tatatctcca tcttctaaat ccgcatcttc 1729801 catgtttaaa atgacacgcg ctcgcccctc tataactccg gaggaaacag gtagacctac 1729861 aatcgctccg gctgggagat tttctcgttt atactcacct gtaacgattt caccatcaga 1729921 cgtgataaca cgtggtggag atagtttttc atataatgtg tactcgtctt ttcgtgtact 1729981 gatgatttga taatccagtt tatgtgtgcg cacgacttcg tgaagttctt caaaagtgag 1730041 atagtatata tcttcttttt catgaataac gcccgcttct atgagttgtt cggcttcttt 1730101 cagtaaagcc tgcttataaa cgaagtatcg attaaccatg ccgtattttg gatattccct 1730161 aaacccgctg aaattccgga tgatatctat cgctcgtttt gtttctttgg ctttttgttc 1730221 accatccggt aattgcttca atcgatctaa taactcttgt tctttcttca aagcttcctg 1730281 tcgcccttgc tcaaatttcc gatggccgac attaggctca aaatttttaa tattattaag 1730341 aatcattggg acaagtgtag ttggtttttc gctccatcga gttcttgtga tatcaatctc 1730401 tccggtacat cgcattccgt atttgctgag ataatcatag atcgcgtctc gggttttgct 1730461 tccgccatca aacttagcca gttcatccaa aaagttatca tcttttacat gttgtaagta 1730521 atcaattacc tctggataag gacgaatcac atctgcgacg tctaatagcg caagacccat 1730581 ttctgaagta atattatggg gtacagattg agaaagcgta tctgctgcgt ttttttcacc 1730641 taaccactcg ttcatttttt cgttaatcca taatgaagca ttcatagcag ttcgaattag 1730701 aaccgaactt tttgggttaa ataaaatctt ctttaattcc tgaatatctt ccagaataaa 1730761 acgaaataaa tctgatcctg atttcgtttg gatgttttgt tttaactctt ctatcgatgt 1730821 ttgactgctc tcaatcaaat cagacacgat tgtcggatcg ttttcaactt gagccggcat 1730881 atctgcattg cctctgctgg gatttggtgc tgttttatca tttggtatcg actttatgaa 1730941 atctcgtcgc tttattatgg tcataagtgc gtcttttaag agctgatcgt gctgccccat 1731001 gccttttaag aaaacttctc tgctgtcagg ggatgccaga tgatgtgtga catcaacaaa 1731061 tagccttcca ccggctttac gcatgggtgc aacagtcgtc aacagaaaaa aagacaatcc 1731121 cagtggtttt atgggatccg tcatcatttg ttgatgacca acagaaatat agacgtgatt 1731181 ttcttggtca ctcgcttcag ggatggggaa taaagtagtg attggacgac tctgtacaat 1731241 ataaaaagta tcgcgggcca aacaccattc gatatcttgc ggctggccga aatgagcttc 1731301 gatctgtctt ccaatgcgtg ccagctgtaa aatttgttca tcagtcagtg tttgagcctt 1731361 ttgctgatca gaatcgatct gctgtgtttc tgttccgcct tcttttcgtc cgtagatagc 1731421 cattttttta gttgctattc tcttatcgat gatttgccca tcctgtactt taaaacaatc 1731481 ggcagatacc aagccagaaa ccagtgcttc accaagtcca aaaccggcat cgatggataa 1731541 cacctttcgg ttggaggtaa tcggatcagc ggtaaataaa atccccgaag cctgagggaa 1731601 aaccatcctt tgaacgataa cggataaata gacttggctg tggtcaaatc cattttgcat 1731661 acggtaaata accgcgcgat ccgtaaatag ggacgcccag catttactga tatgctgcaa 1731721 gattgcatcg acgccggtaa tatttaaata ggtgtcttgt tgaccggcaa aagaagcatg 1731781 tggtaaatcc tcagcagtcg cactagaacg cacggcatag gcatgttcct cgccaaactg 1731841 ggagagatat tgagccactg ctttcacaac atcggaagga atgtctactt ccataatgat 1731901 ttgccgaatc ttccggctga tgttaccaat ctgatctcgg tcctcaactt ttagcatggt 1731961 caattgatcc aacaacactt gtaacgtttc gttttgttcg atggcttttt gatatcctac 1732021 tgttgtgaca caaaatcctt ctggtacttg tataccttga atttttgata attcccctaa 1732081 atgtaaccct tttcctccaa cgagcgaaag ctgtgttttt tcaatttcat gtaaaccgag 1732141 aaccaaagaa ctcattctac atctcccctt caaaaaaaaa tattgacaag agcttcctag 1732201 caggatataa taaaattata agatggatat ctataacttt ttaactagaa agcgcacgta 1732261 gtgtgattat atcaccgtgt ctgtttttgt gcaatataaa aagaacctgg gaaatttcac 1732321 caggttcttt tcttaatttc catagctagt cgcattaaaa aacttggttt gagctgattc 1732381 aatcctctaa ggaaatccta aagttgggtt ctttttgaac ttacttgctt tgttcgtaga 1732441 gtccccattc ataaattgga ctttttgttc ttaacagtcc cacctttaac tagtataaag 1732501 ttatgaggat ctggttaact actagatatt tttattttga ataaggctta tgtttgataa 1732561 agaagggtta tgtaaaggtg tctgttgtga gcaagcgctg actacaaaaa attgatagca 1732621 ttctcattta aataccattc tattaaccta tagggaaagt tttaaaacca gatggagaat 1732681 accctacctc cagcaattcc aaggccgttc acctagtaga aaacaacctt taaccattac 1732741 taacgatttt aataatcatt gattataaaa cttctcaagg aacgatcagc agcccgttag 1732801 ctacccctga ttaaggatga tctgttacca cactgttacg ttagaacttc cactactttg 1732861 atatccttct gtcgccatga cttggtaagc ccaattactg cccagattca ttccatggct 1732921 cttccatgcg ttcacatgat tgctgaaagt gattgtagcg ttgcttccgg ttggtctctt 1732981 cgactggcga acactccagt actgcgtaaa agtagtgcga tcgccatcaa tggaaggtgc 1733041 gttataacgt gtagttgtat atatgtcata tgtaccccca tcacttttta cagtaccttt 1733101 atacgttcca gtaggtctat aagtacccca tgaatccact acataatatt ctatgagagg 1733161 tgatctcgtc caaccatata aagttaaata tccattgcca ttcggcgccc aaactccggc 1733221 attatagttt atcgtcctaa atggcgaacc tgtagtccaa cctttaccaa caacaaaatt 1733281 tccggtatta gaccaattaa cactgtaatt cccgccagac ccattgacag cgtttactat 1733341 accgccccca tcagtccaat tttgccagta gtctgtgcta gctgcagagg cggttgccga 1733401 aaacaagcta atactcatta aagctgccga taatccaact aagaaattct ttttaaactt 1733461 aaacatatgt tacctcctat aatatttttt ccgactttga ggtagcactc gtatacattt 1733521 aaaacattct taattactaa cgccaaagct tttgatcgtc cccttcagta taataccacg 1733581 aattcatgag caaatattaa aagtatttgt aattcaatta caaataccta gaaacacatt 1733641 ataagtggtc ttcttccacc atatcctgat ccgagctcga tgtacatgcc tttacggcac 1733701 acacgaatgt ggcgtgtggt gcatcgcctc aatacgcaaa gacgtttgcc ttaggcaaac 1733761 gtcttttttt gcgttatccg atttttgtgc cgtttgggac aggctgatcc ggctgcaaaa 1733821 ggacgacgtc gccctggccg ggtatgccgc cgaggaccaa gacttccgat ttaaatccgg 1733881 cgatccggcg gggcggaaag ttcacgactg ctatgacttg cttgttgatg agaccttccg 1733941 gcttgtaacg cttcgtgatt tgtgcgctcg attgttttat gccgatttca gtcccaaaat 1734001 ctatcacaag cttgattgcc ggtactcttg cttcaggaaa ttcttccgct tttacaattg 1734061 ttcccgttct gatatccaat ttctcaaagt catcaataac tgccatatca ataactcctt 1734121 tttctcctat tgtaaaggag atatacaata ttcttttaac taaagagcca tcatttttta 1734181 tccgaatata aggtgtttcg atacaggcgg ggcggcattc ctgtgctttt cgtgaaccat 1734241 cttgtaaaag aagaaaggtt ttgaaagccc agcgcctcgc tcacgacggt aagagtttca 1734301 tttctctcca tcagcattct ttttgcttcc tcaaggcgaa ggtcggcaat atagttctgc 1734361 ggggacttcc ctgtctgttt tttgaaccag cttgaatagt aagctgggtg ataatgctcg 1734421 atttctgcca gcttcttaat cgtcagccgc tcaaataaat ggctgtgaat gtatgcaatt 1734481 gaggcatagc tatgggattg aagcttttct tttatgtatt gtactagcat atgaagcgag 1734541 ttggctgttc cggcctttgc ttcctctgtc agcaagtacc tgatcgaaga ccagaaagga 1734601 tcgagggcag cttcaattcc tgatcctgca cgatactcat caattttcat tgcatgaagc 1734661 ggaacatcca gtacaagaca ttcatttctt ccgatagaac ggaagcgatg ctcgcactgc 1734721 ggcggaatat ataaaaaatg atccggattt aatttcacct ggcgcccctc agtctcaaga 1734781 tcaatactcc cttcaagcgg aaaaagaaat tggctgtacg cgtgcttatg tgaatgatat 1734841 agccgtgtgt atgtccgttt ttcgcaaatt atctcttgaa gcgagtccat tagcaaaccc 1734901 cttcctttgg tcatctttta atccggtaat ggtgttccga tataggcgaa aagccgattt 1734961 ttccatataa agaaactgcc gccagatttt ctttcatcac ttgtaaaaac atgcgttccg 1735021 ctccgttgtt ttttgcccat tcagtcaaca ccctgatcac ttgggttcct gccccttttc 1735081 ctctgtgctc ctcagctaca acgatattac taagtccgcc ataaccatca atgacagaaa 1735141 ccgtgccaag cgctgtcagg ctttctttgt catacatctt gaaaaaagtt ttacacggcg 1735201 gcatgcgttc gaatatgtgt ttgtaacctt tgtgacgctc gggtgaaaac ccttctaatt 1735261 gaataaattc atctatccaa acagatgatg gctcttgttc ccacttgtat gtaaatcggc 1735321 tgttgtcatt tgttcggctc ataattgacc ggcacaacgc tgtcatctgg aagcactcgt 1735381 ctaccttttc ataacggctg tctgccaatg cgtcatcaag ccctttcggt gatgcgttgc 1735441 taatatgaaa acaaacaggt aagcctaaac tttgataaaa aagttcggcc tctagctgaa 1735501 aatccccttc aggcatatcc gcagacgtcc atacgctatt tgcccttttg gttacgccaa 1735561 aattcgctct gagaagccat ttccctatgc ttttttgaaa ataagccggc catgaagctg 1735621 ccgctaatcg ttcaatcttg cgaatgtcat ccattgcata atgcctctcc cctatgtata 1735681 ctcccttgat attatacaat attcagaaat ataagacatc catttatttg tttacataat 1735741 atttttattg tttattaata atcctgacaa aaatgtccga attgaaaatg acaggctttc 1735801 taaaatgtcc tcctcacgtt caaatgcttc ttttgcgatt aaaacagtaa agccatgcag 1735861 cagacttctg agcccccttg tcgcatgaat ggcagtcttt tcacttgcat agccgttttc 1735921 aatgagcagc ttcgtcacaa gacagacaat ttggtcagag acgatttccg tccgtttgtc 1735981 gtgaacctta agaagagccg cttcataata tccgggattt tcaattgcaa aatcaacata 1736041 tgcatgagct aaagaaagca tcgcggaatc tccctttcgt tcggttacgg agtccgccat 1736101 ttgatcaaaa agctttgtca gtcctctgac agcaagttct gctctgatcg cttgcagccc 1736161 gttgatatgg ttatacaatg acggggggcg aacattcatt tttttagaaa gtgcagcaag 1736221 tgagacacca tttacccctt cctgatcggc aatctctgct gcagcgtcta caatcatttt 1736281 ttgggtcaaa cctattctcg gtgacatgct catcatcctt tctttgcttt ttggatcgcc 1736341 tgtctcatcc gctctgaagg tgatcgcagg aattttccat gtccgacagc gagacaggaa 1736401 ggcgccttat cggcgagcaa ttgtgcactt ttgatggcct cctccttatt ccatgtggcg 1736461 aaagcgggaa aaggaaacgc ccattttatc tgacctgata cagcgattcc tccgcgcaac 1736521 tgaaacgcat ctcctgctat taaagtgccg tttcttgtat caagaaatga catgctgccc 1736581 ggtgtatggc ccggtgttgg aatggcaagc agagaaccaa ttgtttcacc gcccgtcagc 1736641 agttggtgag gctttgtttg tatgtgtttc ggaatacctc cttttatagg cgtctgcggc 1736701 tcatcttgcc gcaaagatgt gtcaccttgg agcaagaatg aatcccgttc cgagatcatg 1736761 acctttgcat gcggaaatgt ttgtgccaat gtatccagtg atccgacatg gtccccatgt 1736821 gcatgagtca gtaaaatatg ctgaagcggt tttccaagct gattcacagc ttgaataatc 1736881 cctttatagc tgcctggcag tgcggcatca ataagggtga cttcgttttc ttcctctact 1736941 aaatagcaat taaccggaaa caatgctgga aaaaaagtca gctgccaaac cgtttggtac 1737001 tgagtaattc tcatcttttt attcctccta acaaaaacta atggtgttag ttttattatt 1737061 aactaacacc attagttttt caagagttta ttattttttt atcgctacat aaatgttaac 1737121 ttgtgctcgc tgtggcactg cggcattttg atcatacatc tcaaagtcac ctgtaaacgt 1737181 gcgcagatgc cgcttatccc aagtccaaat ttccttccac gtttcaagca caatctcttc 1737241 aataggaccg attctggaag tgaaaacggc gtaagcggaa gccggcaaat caatattttc 1737301 atatggtccc ggaagaatgt cgtcgtattc ctgaaacgtt ccgactgaaa acgtataaaa 1737361 cccattcgtc tcttgttcat aattcgaata taaggcaata atgctcttgt ctttttcagc 1737421 ctgtgataaa agagcgctca tatcctgctt ccataattga tcccacagtg ccggaatcct 1737481 cctttcttcc gtcatttcca gtgcgttgct tgtccgttgt gatagtccgg caaatcgttt 1737541 caggtctaag tgtgttatat gtgaaaagcc catacgatct cctccttttt ttaagattat 1737601 agacaaagaa acctgacagc agtgtgtcag gtttcatata ttttttgcat gtgatgaatg 1737661 gtttctttta ctttatccct tatatgaaga ggctgcagaa cctcaatatc ctttccgaac 1737721 tggagcaaaa aaccgatcag ccattgatct tctggaagtg aaatcaccgc ctggcagatt 1737781 tcatcttcct cacaacagtg aaggacatca tatccgaacc attcacctat acgctgacgt 1737841 gctgacggct gaacaagaat aaccaattca gttaaacggt ccttttggta ccaactctta 1737901 tcccatggca aagtgtccag ctgaatgtct tttctgataa atgtctgatg taagatggcc 1737961 agatctttca tccggttcag tttaaaaaag cgaaaatcat ttcttaccag gcagtaggca 1738021 tataaatacc agtgccccgc cttgcaaacc aatgtataag gttcagtttc ccgaagtagt 1738081 gtttccccgc ttgcgcttgt atatgtaaaa gatatcgtta acaaccgatc gatggcagcg 1738141 ctgattttct cgcgcagcgt cttttgatcc tcagtatggc cccaagccgt catgtcaata 1738201 aaccattttt ctgtttggtg cttaaatgct tgagtagatt gctcaggtat aaggtgtttg 1738261 attttttgat aggctgtgct gtgagaaacg ggttcataca tagatgaaac gctttgcaaa 1738321 gcggaagcaa ttgcaaacaa ttcctcctcc ttcagccact ctctttcaag ccgatacgtt 1738381 tccatgatgc caattccgcc cccggaaccc tgtgaggtca caatcggaat accagcccta 1738441 ttgatcgtct caatatcacg gtaaattgtt ctgacagata cttcaaacag ctcagcaagc 1738501 tctgcagcct gcacttgttt tttgctgatc aataacacaa ccatcgctaa caaacgttcc 1738561 agtttcattc tgcgcacctt ttcttcttgt attttccaac aaaacaatca taacattttg 1738621 ataaagcttg ggcatatcta ttatgcggcg gaatacacct cgcatatgct atgaaaacag 1738681 gggtttcccc ttcttttttg tgttcagtat ttatttcagc tactatttcc gaccggataa 1738741 gcatacactt ctcaacggag gggatttcac atcatgcatc ttacacttca gagcgtttat 1738801 cctgccataa tcatcatctt ttttctgtat aaaaaaatta aaaggtccat cggataccag 1738861 ccgctgaagc cccgctggct gttcacccgt atcattcttt tctcgctgtt tgcttttgga 1738921 ctttcaatct tcagcgccat tcaccctttt ttatatggat atctcatttt gggcattctt 1738981 ggcggatggc tccttgtctt tttcgctaag aaaaacatct cttttgaaaa acgcagagga 1739041 aagatctatt ttcggactca tatttgggta gaggtgattc tcttaacttt atttctatca 1739101 agatttctgt atcgagtgac ggagctttat cttacctcac ctgatctaaa ccgccttgga 1739161 tcatacagtc agtcaatcgg aacggaccct ctgacaattg gcgtctgttt tctgatagcc 1739221 gtttattata tcggtttttc ttcttttatc atcaagctca gcagaaacga acttgaacag 1739281 cacgaataca ataaagaaaa agacatcctt gcccgctaac agcgagttaa gcaaggatgt 1739341 ctttttcaat catgctgtgt atgatggatc atttgctgaa gaacatctaa aacatgttca 1739401 tcctccggag agtaataaat cgatgttcct tctctgcgcg atttgacaag ccggagattt 1739461 tttaaaaatc taagctggtg ggacacagtg gattgcagta aattcagctt ttctgcaatt 1739521 ccgtttactg catgctcacc ttgggacaat aaatggagaa ttctgattcg ggtaggatct 1739581 gaaagcgctt tgaatgtttg cgcgactaga aacagcgtct cctcgtccag atcagcagcc 1739641 gattgttccg tttctctaaa ttcagtcata tgtatcacct ttctttattc atagttttat 1739701 cttataacaa atgcgcttga gtgcaaacca gcctgcttgt attccatttc aatctcatag 1739761 tttaaattta tgtttcaaat caggttttta cttggtctga tataccctct tatgtcataa 1739821 taaaaaaggt catactgctc caaacattga gggtgaaaca cagtgaagaa aaagagaaaa 1739881 ggctgtttcg ctgctgcggg ttttatgatg atttttgtct ttgtcatcgc ctctttttta 1739941 ttggtcctgc tttttttcaa ccgggattta atcaaaaaac ttccgatcga tacgaaaacg 1740001 attgttttgg aacgtttaac cgattacaaa cccttggtgg aagaagagct tgaaagccaa 1740061 ggactctcta attatacatc actcatatta ggcatgatgt atcaggagtc aaaaggaaaa 1740121 ggcaatgatc ccatgcagtc ctctgaatct ctggggttaa aacgcaatga gataacagac 1740181 cctcaactca gtgttaaaca aggcatcaag caatttaccc tcatgtacaa gaccggtaag 1740241 gaaaaaggcg tggatttgga taccattatt caaagctaca acatgggggc aggttacatt 1740301 gattttgtag ctgaacatgg aggaacgcat actgaggaat tggcaaaaca atactccgag 1740361 cagcaagtca aaaaaaatcc tgatctgtat acttgcgggg gaaatgcgaa aaatttccgc 1740421 tatccgtatt gctacggtga ttatacgtat gcagaaaaag taaaagaaaa aacaaaaact 1740481 gttgaagaat ctttgcaggt tgcaacactt gaaaccatgg aatccaaggc tcatgaataa 1740541 gagtctatca atttactgac aaaagcccaa aaatgaattt gggcttttgc catgtttaca 1740601 cgtaaaaaaa gccatactga gtatggcttt taataatacg gtgaaatcat caaatataca 1740661 ataacgcctg taaggcttac atacagccat agaggcattg tccatctcgc aattttttta 1740721 tggcgctcca cctgcatgct gaagcctctg atcagcgtaa acagcgcaag cggcacaata 1740781 attgcagaaa ggcagatatg tgtaattaaa ataaagaaat aaatcgggcg cataatacct 1740841 tctccgccat agagcgtgtt ttccgcaatc gagtggtacg tcacatagca aatcaaaaat 1740901 agtaatgttg ttgtgaacgc agccaaaata aagcgtttgt gagctttgat atttttctgt 1740961 ttaatcataa tcagcgcggc caataagaag ataaacgtaa agctattgaa tatcgcattc 1741021 agcattggca aaatgtgaat attcgcatgg ctgaactgat ctaatttagg cataaaaaac 1741081 agcactgcga ttaaaccgtt aatcagaact gtcagcgtaa ggacaatccc cgtgtaattt 1741141 ttcggtttat tttctgtttg gttcatttgg tgacctctcc taatttgtac tggctatcca 1741201 aatcgtatgc aaattcaaag aagatgtcaa cggtttcgat tgcttcgtca gaaattagac 1741261 acacttcaaa ggccggaggc tattagcccc ggcctgttag gtttacgcct cttttatcaa 1741321 atgttcaatg accttatgtt cattttcatt cagcaggttc ttttgaattt tcgaatgaat 1741381 gggtttattc atatgctgat ccaagatatc ggccgtttct ttatccccgg caataaccat 1741441 tcgttcccat cttttcgcgg cagctttttg atcaaggctg gcagccagcc gcttatacag 1741501 tctcgattgg ttctctgtta catgttccct catccggttc tcttcaaatg gtggcgcttt 1741561 gtctacagcg gaatggctat tcttccaaga ctcattgatc atatcatact cataacgctc 1741621 caccgcctca atttttccta aaacagtttc aataattttc acttcatgct gctgagttaa 1741681 aataaacgcc gtacttgggt atgtctggcg caaacccttt agctgatcca ggacagctgt 1741741 ttcttcccag taaaatcttg tatctacagg gacttgaagc ttaataggtt cccatatgcc 1741801 gctgtcggaa acaaaaaaca cgagactgcg gggcatgtct tttcccattg cattcaagta 1741861 ttgattcatt ttagccctga ttccatccag acacttttcc tcctctggat cactagctgc 1741921 caaatactct tttaatcggc tgaatcctga ctttagggca atcttccatt ctcccccctg 1741981 ctgctctgga tctctcatgt ctgtattgag atacagagag agaattttat ccggcggttc 1742041 caattggaca tactgtaatt tgttaatcaa tgaatcaatc gccattccga ttcctccttt 1742101 ttcacaggtt agttttcttt ttcctctctt aaaaacgatc aaacctgact ttccgctaat 1742161 ttctagtaat aatggaattg ttgtttacaa tacgcctctc ttctaataca attggtaact 1742221 gtgtttctaa gctgtttttt gaaaggagtt tgatcttgtt tactgttaaa gaaaaaaatc 1742281 gtcaagagct tgaggaagaa ctaaatgatt tagaatttca aatttatcgc atgcaggaga 1742341 atatgaagga tttatctaaa gatgccaaag tgcttggtat tgatcaatcg aaacatgatg 1742401 agtggatgat tgtttcctcg attgatgatg gccaaacatg caaaattatg ctaactgatt 1742461 gtaaaacggc ataccgagga aaaggctgtt tttcacttgt agcgtcttac aaggacgatg 1742521 ccattcatat aggggatata aaaggccctc cgaatcacgg gtttggctcc atttgcatga 1742581 aatatttaaa agatattgca agagaccata atataccgaa agtcaccgga gacatcgcca 1742641 aacgggattg gaatcatgta gaccggctga ttcactttta tgaaaaacat cacttcaaag 1742701 tatgtatcga tcatgatacc caatccggca gcattaagtg ggttgatttg taaaaaagtc 1742761 tggaagaaag agccaagata tgctgtaatg gtataaaacc attgatggag ggttctatgt 1742821 acgcctcaaa actgaaaaag ggagacgaaa tccggatcgt gtctcccgcg accagcatgt 1742881 ctatattatc aaatgaagca aaaatccaag caaaaacggc gttagaacgc ttaggttatc 1742941 gggtaaccat cgctgaacac gcaaatgaat gtaacgaatt tgattcatcc tctatcgagt 1743001 caagagtcca tgatctgcac gctgcctttt ttgatccagg cgtcaaagcg attttaacga 1743061 cactcggagg gtttaattca aatcagctgc tgcgttatct tgattacgag aaaatcaaac 1743121 gacatccaaa aattctgtgc ggttattccg atataaccgc tctttgcaac gctatttatc 1743181 aaaaaacggg tcttgttacg tattcaggtc cccacttctc aacatttgca atgaaaaaag 1743241 gactcgatta tacagaggag tattttcttt cttgctgcgc ttcagacgat ccgtttgaaa 1743301 ttcacccctc aagtgagtgg agcgatgatc gctggttttt ggatcaagaa aacaggcgtt 1743361 tttatcctaa taacggccct gttgtaatcc aagaaggtta tgcggaaggt actttaattg 1743421 gcggaaactt atgcacgctt aatttgctgc agggaacgga gtattttccc gaaacagaac 1743481 atactatttt attgattgaa gatgattata tgtcagacat ccatatgttt gaccgcgatc 1743541 tgcaatcact catccacctc cccgcttttt cacatgtaaa ggcgattttg atcggcagat 1743601 ttcagaaagc atcaaacgta tcaatagatc ttgtaaaagc catgatcgaa acaaaaaaag 1743661 aattatccgg catcccgatc atcgcaaata taaatgccgg acatacctcg ccaattgcca 1743721 cgttccctat aggaggaaca tgcaggattg aagctatttc gggtacatca cgaatatgga 1743781 ttgataaaca ttaatcagct tgtaaatttt tttacaagct tttttagcgc aatcggctat 1743841 gcatgccgca cgagacatga caaatgtcat ataggaggca tgatgtgtgc tactacaaaa 1743901 gacttctctc attagcgtat actgaaccga gacacacaat gagaggatac ttactatgac 1743961 tgaacaaacc attgcacata aacaaaaaca gctgacaaag caagtcgctg catttgctca 1744021 gcctgaaaca aaaaacagcc tgattcagct tttaaacacg tttatcccat tcttcggcct 1744081 atggtttctt gcttatctca gcctcgatgt ctcctatctt cttacgttag cattaacggt 1744141 gattgccgca ggttttctga caagaatttt tatcatcttc catgactgct gccatcaatc 1744201 ttttttcaaa caaaaacgct ataaccacat tctcggtttt ctgacaggtg tcctgacttt 1744261 attcccgtat cttcaatggc agcacagcca ttcgattcat catgcaacta gcagcaatct 1744321 ggataaacgc ggaacaggag acatctggat gttaacagta aacgaatata aagctgcatc 1744381 cagacgaaca aagcttgcat acagacttta tagaaacccg tttatcatgt ttattctcgg 1744441 accgatttat gtttttctga tcacgaaccg ttttaacaaa aaaggcgcaa gacgcaagga 1744501 acgtgtaaac acatacctta cgaatctggc aattgtcgcg ttggctgccg cttgctgtct 1744561 gatctttggc tggcaatcgt ttttactggt gcaaggcccg atatttctga tttcaggttc 1744621 aatcggtgtt tggctgtttt atgtgcagca tacctttgaa gattcttatt ttgaagcgga 1744681 tgaaaactgg agctacgttc aggctgctgt tgaaggcagc tcattttata aactcccgaa 1744741 actgcttcaa tggctaacag gcaatattgg ttaccaccac gttcatcatt tgagtccaaa 1744801 ggtgcctaac tataagcttg aagttgctca tgaacatcac gaaccattaa aaaacgtacc 1744861 gacaatcacc ttaaaaacaa gcctgcaatc acttgcgttc cgtctatggg atgaagataa 1744921 caaacagttt gtgtcatttc gggctataaa acatatacct gtaagccttc cgcctgattc 1744981 accagaaaaa cagaagctgc ggaagaatgc ctgatgataa aggaggtctt ctaatatact 1745041 agaaggcttc ctttttattg ttggagggtg cattctggct ttcacaatga taaagttaca 1745101 agtaagatga aaagctgaaa atgaggtaag atcatgatta aaaatcattt tacatttcaa 1745161 aaactaaacg ggattacgcc ctatatatgg acgatatttt tcatcctccc cttctacttt 1745221 atatggaaat catcatctac atttgttatt attgtcggca tcattttgac gcttttattt 1745281 ttttcggtat atcgatttgc ttttgtctca aaaggctgga ccatttattt gtggggattt 1745341 ttattaattg gcatttcaac cgcctccatt actctgttca gttatattta ttttgctttc 1745401 tttattgctt attttattgg aaacattaag gaacgcgtcc cttttcatat tttatattat 1745461 gtccatttaa taagcgcggc cgtcgcagcc aatttcagtc tcgtattaaa aaaggaattc 1745521 tttctgacac aaattccttt tgtcgttatt accctcatca gcgcaatttt attgcccttc 1745581 agtataaaaa gccgcaagga gcgcgaacga cttgaagaaa agctcgagga tgcaaatgaa 1745641 cggattgcag aactggtaaa attagaagaa cgtcagcgaa ttgcccgcga tctccatgat 1745701 acgcttgggc aaaagctttc tcttattggt ttaaaaagcg acttagcaag aaaattgata 1745761 tacaaagatc ccgaacaagc agctcgtgaa ctgaaaagtg ttcagcaaac agcgcgaact 1745821 tctttaaatg aagtaagaaa aatcgtttcc tctatgaagg gcatccggct caaggatgaa 1745881 ttgatcaaca tcaaacaaat tctcgaagca gctgacatta tgtttatcta tgaagaagag 1745941 aaatggcccg agaatatctc attgctgaat gaaaacattt tgagcatgtg cttaaaggaa 1746001 gctgtcacaa atgtcgtcaa acacagccag gctaaaactt gccgagttga cattcagcag 1746061 ctctggaagg aagttgtgat tacagtgtct gacgatggaa cattcaaagg agaagaaaat 1746121 tccttttcaa aaggacatgg cttactcggg atgagagaac ggcttgagtt tgcaaacgga 1746181 agccttcaca tcgataccga aaacgggacc aagcttacca tggcaattcc taataattca 1746241 aaataaacat aaaggatggc ttatatgatt agtatattta ttgcagaaga tcagcaaatg 1746301 ctgctgggcg ctttaggatc acttctaaac ctcgaagacg atatggaagt cgtaggcaaa 1746361 ggtacaaccg gccaagatgc tgttgatttt gtcaaaaaac gccagcctga tgtatgtatt 1746421 atggacattg aaatgcccgg aaaaacaggg cttgaagctg ctgaggagct aaaagataca 1746481 ggctgcaaaa ttatcatctt aaccaccttc gccagacccg gttactttca gagagctatt 1746541 aaagctggcg ttaaaggcta tttgttaaaa gacagtccga gtgaagagct ggccaacgcc 1746601 atccgtagcg tcatgaacgg aaaacgcatc tatgcacctg aactgatgga ggacttatac 1746661 agcgaagcta accctcttac agatagagaa aaagaagtgc tcgaacttgt ggctgacggt 1746721 aaaaacacaa aagaaatcgc tcaggaactc agcatcaaaa gcgggacggt gcggaattat 1746781 atctcaatga ttctagaaaa gcttgaagtg aaaaatcgaa ttgaagccat tacccggtca 1746841 aaagaaaaag gctggtttaa ataaaaaagg atcttggcat ctgccaggat cctttttgtt 1746901 aacctgaaat tcccgtttga gaacctcgtc gcaaccagaa ttaaattgat ccatatcctc 1746961 gctcctacgc ccgctgaacg attgtttggt taacagccca ataaaagact ggattgaatg 1747021 atatccctgt taaaatggtc ggccattgca catcagcaga atttctgata ttgattatat 1747081 tgtattttca gtatgacaaa gttgtgccac ttcgctcccg aagctgccat gcccaactgc 1747141 aagagcctaa tatcacaata aaaaaccgtc tgaaatcaat ccgattccgt aaatggtatc 1747201 tgctacatcc aactgcttat tatctgccaa aaacaccagc tcgtttcgct gatcaaagat 1747261 agtaacaacc agctataaat gtcatgatgc cgaatgtctc tgtaatgtgg aatcaatctt 1747321 ttaacccgag agcccctgaa tcgcacataa agaaaaacgg gaccactttc ttttatcagc 1747381 atatgatata aacagctcta agcagaacaa aaaaagacac aagccaaaag cttatgtctt 1747441 ttatcacaat ctatattatt agtttaagac tttaacactt acagttttga cgccccaatt 1747501 agaagcatca cttttacttg gtacaaatac gtcgatttta tttcctttaa tagcgccgcc 1747561 agtgtctgct gctgttgctt ccccgtagcc ttcaacatag actttagaac ctagcggaat 1747621 tacattagga tcaaccgcaa taactttcgc gttcgggttc ttatttaagt caatgcctgt 1747681 agctgtaacg ccggaaatgc cgccgtcgtt agcagtgtaa gcagtagcag taactgttag 1747741 ttcttttgaa gcttcttgat tatttgtatt tgattgaaca gccttctcct ctgtgttaac 1747801 agaagtttct gcctcagcct ttgtttcttg tttaggttgc tgttgtacag cttcttgttt 1747861 aggttgctct ttttgcacag cctcttgttt tggcgcagct tgaggtgcgt ttgtttgcgc 1747921 attctcagta gctgtgtttg ctgctgttgc ctgacctttt actgaaagag ttgatccagc 1747981 atagatcatg tcagagctta agttattcca aactttcagg ttgttgactg tcgtgccgaa 1748041 tttttgagca atcttagaaa gcgtatctcc cgctttaatt gtatattgcc cagtcgtggt 1748101 tgtttcttct gaagaaatgg tcagtttttc tcctgcaatg attttatcag aagttaactt 1748161 gttccattct tttaagtcct ttaggttcac tccatttttc tgagagattc cccagagcgt 1748221 atcacccttt tgcaccgtaa tttcttttgc agaagcgtga gctccgaatg cagttgttga 1748281 aagtgcagca actgccacaa aggacataat cgtcttcttc ataagtaaat cctcccttgt 1748341 tagcttttta ttggcggcta acaggtgata tcgtaacaca cgtaaatgtc aaatcaataa 1748401 caaaaagata tgatttagat tacagttcct ttacatgaag gatttctctc tgatggaaag 1748461 acttgctgaa cccttgatat aataggcttc gcaggtcttt ttattttgag gcgaaacaga 1748521 gaaaataaaa tgtgtttttt atagaaaaaa agattgtttt tctgtttttt tagtctgtca 1748581 tccttgcata agcctgtatt tcttgtaaaa aaagccggcc gtattttgct cttttttgtt 1748641 ctccgactcc ttttatagac aaaagttcat catcatttac gggctgtttt cctgacattt 1748701 cttttaacgt ttggtcagag aaaacaacaa atggcggaac accctgctca gccgcaattt 1748761 ctttccgaac catgcgcaat cgttcaaata gctcgtcatt ttcagtaatc gctgccgctt 1748821 ttaacgcttc ttttctcgct actgataatt ctcctttcag cacattcctt cctttactgc 1748881 tgacaaaaag agtcggaaac gttccgtctg acatcctgat gaagtcgtca gaaataagaa 1748941 attcgataaa atcactgatt tcgccaacgg attggtgttt taatatcccg tatgttgaaa 1749001 ggtcggaaaa gccgttttca agaacttttt tatttttgga gccggcaagc acctgggcaa 1749061 ccatcgtctt gccaaaccgt tctttcatgc gaatgataca agataagacc atttgcgcct 1749121 cccgcgtcac gtcatgggcc gctcttgtat cggtacagtt tccgcactgt ccgcacgcat 1749181 caggctcctt ttctccgaaa tacataagga taaaacgctg cagacaatct tccgtatgac 1749241 agtagtcgac catttgtctc agctttttta aatcctgctt ttgtttctct tcatgttctg 1749301 attgctcaat taagaagcgc tgcaccataa tatcctgcgg tgaaaacagg agaacacatt 1749361 cactggcaag accgtcccgt ccagctcgtc ctgcctcttg ataatagctt tccatatctt 1749421 tcgggatttg tgcatgcaga acaaatctga tatttgattt atcaataccc attccaaaag 1749481 cagaggttgc caccatcact tgaagctcat cattaagaaa tctttcctgc tgctcttttc 1749541 tcacatcatc agccaaacct ccatgatacc ggcctgccct gacctgattt cgtttcaatc 1749601 tctcatatat ccgatcagct tcttttctgg tcgctgtata gacaattcct gcttcatgcc 1749661 tgttgttttg cacatattcg tctataaacc gatctttatt ttctcctttt actactttaa 1749721 aggttaaatt ctctcgggaa aatccggtat ataccgtgtt ttctttttga atatgcagct 1749781 gtttgcaaat atcatcatga acctcgggtg tggctgttgc tgttaacgcc atgatgacag 1749841 gcttgtcgtg taattcacgg aacaagattt caatattcct gtagcttggc ctgaaatcat 1749901 ggccccattg agaaatacaa tgcgcctcgt ctattgcgac caaaggaaca tctatgccct 1749961 gcaaaatccg gataaactct atggacgtta gtcgctctgg tgtaatgtaa aaaagcttat 1750021 aagccccttc tttgagtccg ttcagcctct catatatttc ctgattggat tgtgtgctgt 1750081 taatgtaggc ggcgttaatc cccgcttctt ctaacgcatc aacttgatcc ttcatcaagg 1750141 aaatcaacgg tgaaatgacg atcgtcgtcc cttcaaacat taatgccgga atctgatagc 1750201 aaatcgattt gccgcctccc gtcggcataa tgcaggccgt attttgcctc gcttccgtca 1750261 ccaagcggat cgcttcatct tggccgctcc gaaacttctc ataaccaaaa taatgagcca 1750321 gaagggattg ggctctatgt aacataacgt gtaaacctcg cttttccttg aatttctccc 1750381 atcatatcat aaaaaagcgg ccttcatttc tttcacacaa aaatggaata ttcactatac 1750441 caaacctttt tagataaaat aaaaagccat ttccgaaaag gaaatggctt tcgctacgtc 1750501 ttgccgtatg caagtaagaa agttttaaac caccactcct caaagtgggt gtttgcagaa 1750561 acgttcctgt cgtcctctgc aatggaggca tgacattccg gcttcgatat aaaactccct 1750621 attacagctt aaaggttaaa acttaattaa caatacgcac aaagtagctt ctttaatata 1750681 gtacaccatc aggcgctttt aatcaagagg tcagaacaat tgtttagaaa aactttttcc 1750741 agtgaataaa actgtttttt ctccaaaata cctgacaatt cgacaaacaa aaaatatatt 1750801 acaataaaaa aaatagcctt tattgctaaa agcgaatgat tattttcttc tatattaatg 1750861 tgtatataca aaaagactcc tatttgtaac gataggagtc ttggctttat tagaattttg 1750921 cagcaagatc ttttgcttct tgtaaacctt tttcaacgat ttcttgcgct tgatcaggtg 1750981 ctgcgttatg tccttcgatg acaactgtgt gcaagtcttg aacaccccag aaaccaagaa 1751041 ctgttttcat gaagtttaat gacatttcaa gtgcagccat tggtccttct gagtagacac 1751101 cgccgcgagc gttaagaagc gcaacttttt tgccgcccat taaaccgact ggtccttctt 1751161 gtgtgtattt gaatgtaacg cctgcgcgag acagataatc aacataagta tgaagcactg 1751221 ctggcactgt gaagttccaa agcgggaatg cgaaaacaac tttgtcagct tttacaaact 1751281 ggttcagata tttgtcagca attgctgctt gttttttctc atcttctgtc atttccattc 1751341 cttgacctgc tttaaatgtt ccgttaatca tatctctgcc aaggtaagga aggttttcct 1751401 tatgaagatc taattcaacc acttcatcat tagggttgtt ttctttataa gcagctaaga 1751461 aagcttcgta aagtttagtt gaaacgcctt cttcagctgt acggtcgctt gattttacaa 1751521 ataaaactgt agacatttgt attcctcccg gtaaactttt tatatttact tacaaatagt 1751581 atgttacttt cttttttacg taaagtcaat cactttattt tgaatatgag attttttttc 1751641 aaaaaaaagc aagtacatct aatatcggtg tacttgcttg gcatttttac ttcgaatctt 1751701 gttcacgatc caagatttca tacgtctgcg agcttttttg atcaattgtt tctttgttgg 1751761 ataagtcttt tacctgttca tgaaactctc tttcataaga aggagcatct gtctccagat 1751821 catcctccac atcagcttgg gcctcaactg tcattcttgc ataaggaaca gcttcaagtc 1751881 tttcgtaagg aatctcttgg ccggtttttt cacacacgcc ataagttccg tctttcatct 1751941 tttgtaatgc acggttgacc tcctctaaca gctcccggtc aatctctttc actgtttggt 1752001 ctgtcatccg gtctgtgacg agcgtcccgt ggtctgccat atggttgtca accccattgg 1752061 aaagctcccc cacttcttcc gtcattgatt ctgtttcctt tttctcgcca gacaattctt 1752121 tttgcatatc gagcaattta tgatagagat gctgtgtttg ttcttttgtc agtgccatgt 1752181 atatcctctc ctttctatcc tgtttcccgt tttgccttct gtcaaacatg gaaacatcga 1752241 tggaaagatg agctactgcc tttttgaacg gatcgtgacc gctggcgtcg atggtgcttc 1752301 gggttttcgt tggcactttt tgtccttctc ttctggcggt atataatagg ttgcgcctat 1752361 atttaatctg ccgctcagtt catcaatggt cagctcgccg aattcaagat gatagtcaac 1752421 tttttcgaca ttcagcgttt caatatgtat ataggtttct tcagactctt gtttgctgct 1752481 ttgtttttgt ttctcaatca ctgagagtct ttcttcacat tcacgcagtt tgtcaagttc 1752541 tggtttcaag caatgcctga tcagcgaccg gaacattttt ttcatgacat cacgaccctt 1752601 tgcatactcc tctttcgtct acatatataa tgaggtatat cccatagaaa ggagaggttt 1752661 tcatgcttcc gactaacatc aatatttctc atctcaagac taactcgata ggcaccggct 1752721 catcccttac ctttggttct gcggagttaa ggaacaggtg ctctgctatc aaaagaaata 1752781 acggttttgg ggaacaaaat gcagatggta ttgttatggt cattccgatt gaatcaattg 1752841 atgaccgtga tgtgtcagat gcactcagta tgaaaatcaa tcatcaataa caatggtttt 1752901 cgcttgacct tcgtcttttt gaatagtgat gtataggatt ccgtctttaa aaatggcatt 1752961 catctttcca tgaagatgat cggaaagcgg aattttcttt tcaaaacttc cgtatttccc 1753021 ttctttttgg cgaaagtcct gttcattaaa ataggaaaag cgctgcccct tcaccactaa 1753081 ataatctccg tacgataata tgtgaacgtc ttgtttacgg tagcctggaa gataaattaa 1753141 aaactgcact tccgcaacgg tatctacaat atccatgctc ggaaatgaag catctccttt 1753201 ccctcgctga tcttgctgcg caaacggaaa cggagattgg ccatttgtca taaaaggggt 1753261 tttttggtct tcatcaaata cctgtttcca aaagtcaccg ccgtacatct gctgtgcgaa 1753321 ttccatccac tgcttcatct tttcgaaatc catttgaagc cccctgtctt aacatacttt 1753381 ataaccgcca gcatacaact atagaaagga ggtttgcctg tggttcaacc aactccgtat 1753441 atcaatatta atattttcat gctgaaaatt aattcctttg aaaatgcttc agcggttaac 1753501 gtaggacaaa atttattggc agaatggcaa aattcagata aaaaaaatca aggctacgga 1753561 cagaattttg gagatgcgag cggatttatg ggcacgagaa gccatgtgga tgacagagac 1753621 caaattgatt ctccggcctc ttttgaaagt gaagcggtta actcctcaat caaaaggaag 1753681 tgatgagatg ttcttttcac cctccgtcgt aaatgtcggc ggatttaaaa tcaatacgat 1753741 ggatcgaggt tcctctttaa cactcggtcc gtatcagcag gtcgattact ttttatcagc 1753801 taaaataaat caagggtttg gagaagaaaa tggcgacttt actcctcttg tcgtgccgat 1753861 ttcaaatgta ttagatgcag atcttgttga ttcgaactca gcgaaaaaca gtgtggtgta 1753921 ataagaacag ggcgcacatg ccctgttctt gtttttatat ataaaaaaag cctaaccatt 1753981 ttttgaacgg ctggctcatc aaatattcag ctgcacaaat gctttgtcag caccgcctga 1754041 acctcgctta aatcggtgtc tttcgcaaat tctaattcga aagttttgct tcttgtcatc 1754101 aataaaagcc cagtgtccgg atcaaacatt cccgcttctt ggatggcaaa gctttcaatt 1754161 gttttatatg gaagaaatac acgaaccttc tttttagaaa acattttatt gtcaaagaaa 1754221 atgatccgct tatttgtaaa gcaaatttgg tccactcgga gcttataaat cgattcaatt 1754281 ctttcccctt caacgagcaa agcctcaagc ttctttgcgt ccgttgatct gctaacagaa 1754341 aaaataccca atgaagaacc cctctttctg catttatcta tttgttttat cattcactac 1754401 ataaaaataa gtcctttatc cctatataag aatacgacat agaagacatt taaaccatta 1754461 cgaacagatt acatttttca aatttttgat ttgttttttg gcttttaagc tgttgtcatc 1754521 aagtaatacg cacatataga gaaaaaagtt tcaatattca gcaatgtttt tataaaaaag 1754581 tggtttttaa tgattttttt aattttgttt tatatttcct gttttaacca caaaaaaacc 1754641 gcagctgagc tgcggtttta tgtatcgact gcttttaaca aaatctgttt gatgcttcaa 1754701 ggaagcatta catctcttcg aagtattctt tataatagcc gccgacttta ttcgtattgt 1754761 cgaccacaaa gagaaactcc tctgtttcat tttttacttc atattctttt cccggcgtta 1754821 aaacgcggtt tacgatatat ttttttgcgt ttgtctgcac acactttact tttttaatgg 1754881 tttctttttc aagccaattt ttatgaatca tgatgaaatc tccttttctt atctataagc 1754941 ttattgtagc ttttttcttt tgtaaattgc aatatcggtt attcattgat tttgccttga 1755001 tttctattat agaatgtttg tatacgctta cgtttgaagc aactatcaca gcttatttct 1755061 gctattcaat ccaggaatca atgtgctatc accaagaatc tcagaacaga ccataaaaaa 1755121 tgactggagg tttgttacgg atgagttctt taacgatgca agtgacgaaa aggctggaga 1755181 catttttaca gggaacaaag aagctttata ttgacggaaa gtttgttccg agtgcctcag 1755241 gggcaacctt tgacactcca aacccggcga ccggcgaaac cttgatgacg ctgtatgaag 1755301 cccaggctgc ggatgtggac aaagctgtta aagctgcccg gaaagccttt gaccaaggtg 1755361 aatggagaac aatgtctcca gcttcgagaa gcagactgat gtataagctg gcagacttaa 1755421 tggaagagca taaaactgag cttgctcagc ttgaaacact tgataatggg aaaccgatca 1755481 atgaaacgac taatggagat attccgctgg ctattgagca tatgcgctat tacgccggct 1755541 ggtgtacaaa aataacagga cagacgattc cggtttccgg cgcttatttt aattatacgc 1755601 gtcatgagcc tgtcggtgtc gtcggccaga tcattccatg gaatttcccg ctcctgatgg 1755661 cgatgtggaa aatgggcgcg gcacttgcaa caggctgtac aatcgtcctc aaaccggctg 1755721 aacaaacacc gctttcagct ctttatttgg cagaattaat tgaccaagcc ggtttccctg 1755781 ccggtgtaat caacatcatc ccaggattcg gtgaagatgc gggagaagcg ctgacgaacc 1755841 acgaagcggt tgataaaatt gcctttaccg gttccactga aatcggaaag aaaatcatgt 1755901 ccaccgcagc gaaaagcatt aagcgtgtga cattggagct gggcggaaaa tcgcctaata 1755961 ttcttctgcc ggatgcgaat ttaaaaaaag ccatcccggg cgctttaaac ggtgtgatgt 1756021 ttaaccaggg ccaagtctgc tgtgcgggct cacgtgtctt cattcataaa gaccaatatg 1756081 atgaagttgt tgatgaaatg gcatcctatg ctgagtcact ccgccaagga gcgggacttc 1756141 ataaagatac tcaaatcggg cctctcgtaa gcaaggaaca gcatgagcgc gttctttcct 1756201 atattcaaaa aggaaaagat gaaggagcaa aagcagtgac cggcggaagc tgtccttttg 1756261 aagcaggata ttttgtcgca ccgactgtgt ttgcgaatgt tgaagacgaa atgaccatcg 1756321 caaaagaaga aattttcgga cccgtgctga ctgcaattcc gtacgaaaca gtcgatgaag 1756381 ttattgaacg ggcaaaccat tcagaatatg ggcttgcagc cggactatgg acagagaacg 1756441 tcaagcaggc tcactatatc gcggaccgac ttcaagccgg aaccgtttgg gtcaactgct 1756501 ataatgtgtt tgacgcggcg tctccatttg gcggttataa acagtcagga ctcggacgag 1756561 aaatgggatc atatgccttg gataattaca cagaagtcaa aagtgtatgg gtaaaccttg 1756621 aagactaaca tgtatgttta aaaaactgct gcctgccagc agtttttttc tttctgtaat 1756681 ggcagtaaaa gacgctgaat atatatgctt ctgaaggagt tgagcgtgat gggcacactt 1756741 caggagaaag tgaggcgttt tcaaaagaaa accattaccg agttaagaga caggcaaaat 1756801 gctgatggtt catggacatt ttgctttgaa ggaccaatca tgacaaattc cttttttatt 1756861 ttgctcctta cctcactaga tgaaggcgaa aatgaaaaag aactgatatc atcccttgca 1756921 gccggcattc atgcaaaaca gcagccagac ggcacattta tcaactatcc cgatgaaacg 1756981 cgcggaaatc taacggctac cgtccaagga tatgtcggga tgctggcttc aggatgtttt 1757041 cacagaactg agccgcacat gaagaaagct gaacaattta tcatctcaca tggcggtttg 1757101 agacatgttc attttatgac aaaatggatg cttgccgcga acgggcttta tccttggcct 1757161 gctttgtatt taccattatc actcatggcg ctccccccaa cattgccgat tcatttctat 1757221 cagttcagct catatgcccg tattcatttt gctcctatgg ctgtaacact caatcagcga 1757281 tttgtcctta ttaaccgcaa tatttcatct cttcaccatc tcgatccgca catgacaaaa 1757341 aatcctttca cttggcttcg gtctgatgct ttcgaagaaa gagatctcac gtctattttg 1757401 ttacattgga aacgcgtttt tcatgcacca tttgcttttc agcagctggg cctacagaca 1757461 gctaaaacgt atatgctgga ccggattgaa aaagatggaa cattatacag ctatgcgagc 1757521 gcaaccatat atatggttta cagccttctg tcacttggtg tgtcacgcta ttctcctatt 1757581 atcaggaggg cgattaccgg cattaaatca ctggtgacta aatgcaacgg gattccttat 1757641 ctggaaaact ctacttcaac tgtttgggat acagctttaa taagctatgc ccttcaaaaa 1757701 aatggtgtga ccgaaacgga tggctctgtt acaaaagcag ccgacttttt gctagaacgc 1757761 cagcatacca aaatagcaga ttggtctgtc aaaaatccaa attcagttcc tggcggctgg 1757821 gggttttcaa acattaatac aaataaccct gactgtgacg acactacagc cgttttaaag 1757881 gcgattcccc gcaatcattc tcctgcagca tgggagcggg gggtatcttg gcttttatcg 1757941 atgcaaaaca atgacggcgg attttctgct ttcgaaaaaa atgtgaacca tccactgatc 1758001 cgccttctgc cgcttgaatc cgccgaggac gctgcagttg acccttcaac cgccgacctc 1758061 accggacgtg tactgcactt tttaggcgag aaagttggct tcacagaaaa acatcaacat 1758121 attcaacgcg cagtgaagtg gcttttcgaa catcaggaac aaaatgggtc ttggtacggc 1758181 agatggggtg tttgctacat ttacggcact tgggctgctc ttactggtat gcatgcatgc 1758241 ggggttgacc gaaagcatcc cggtatacaa aaggctctgc gttggctcaa atccatacaa 1758301 aatgatgacg gaagctgggg agaatcctgc aaaagcgccg aaatcaaaac atatgtaccg 1758361 cttcatagag gaaccattgt acaaacggcc tgggctttag acgctttgct cacatatgaa 1758421 aattccgaac atccgtctgt tgtgaaaggc atgcaatacc ttaccgacag cagttcgcat 1758481 agcgccgata gcctcgcgta tccagcaggg atcggattgc cgaagcaatt ttatattcgc 1758541 tatcacagtt atccatatgt attctctttg ctggctgtcg ggaagtattt agattctatt 1758601 gaaaaggaga cagcaaatga aacgtgaatc ttatcaagcg gagatgttca attggtgtga 1758661 agccctgaaa gatcagattc aaaagcgagg tcagcttgac cagtttgaag atcaaatcga 1758721 caagatgatt gaggctctgg aagatgacca aacaacagaa gaagattggt ataaacaggc 1758781 cgctgccctt tatcgggata ttacagaatc agatgataca agtgaaagac gcgcttatgt 1758841 ccctataggg aaacacgtgc tgccaaagct tccttacaaa tactccgcct tagaacctta 1758901 tatatcacgc gatattatga tccttcatca tacaaaacat catcaaagct atgtcgatgg 1758961 cctgaacaaa gcagaatcag agcttaaaaa agcgagagcg acaaagaatt atgacttaat 1759021 cactcattgg gaaagagagc ttgcgttcca tggagcaggc cattatttgc atagtatttt 1759081 ttggttttct atgcatccaa acggaaaacg gcgtcctaca ggggcattgt tccaaatgat 1759141 agacctttca tttggaagct attccgcttt taaagaacat tttacccagg cctctaaaaa 1759201 agtggaaggc gtcggctggg ccattctggt ctgggcacct cgatcaggac ggctggagat 1759261 tttaacggca gaaaaacacc agctctttag ccaatgggat gtgatccccc ttttaccgct 1759321 tgacgtatgg gagcatgcct actatttgca atacaaaaat gaccgggcca gctatgtcga 1759381 tcactggtgg aatgtcgtgg attggcgcga ggctgaaaaa cgttttgagc aggcaaaaga 1759441 agtcgtttgg aagctctatt aaaaaaagcc ccctttcctc gggggcttcg tgtgttaaaa 1759501 aatacctatc acatgcaaaa acacgatgat gatggcaaca ggagatagat atcgaatgag 1759561 cagcagccaa accgcaaacc actttcgttt gagattggaa ccgcttttca gctcgtcaaa 1759621 caaatcctgt ttcggtattt ttagcggaac aaaaatcgaa atcagtaacg cacctaacgg 1759681 cattaaaata ttgctcacaa gatagtcagc cgcatcaaaa atagacagat gaaatatagt 1759741 gacgtcactt aagacaccgt atgataatgc agacggcaca ccgacaataa aaatagcaat 1759801 accgcctaac caagcgaatc gttttctctt attgatatcg cctttcgaca gtactgcgac 1759861 caaaatttcc agcattgaaa aagcagatgt caatgcagca aataaaaata gaagtaaaaa 1759921 tgctaataaa aagataattc cgaacggcat ttgattaaac acagtcggca gaacgttaaa 1759981 taacagaacc gggccttggt ctggcttgag gccgaatgaa aatacagctg gaaaaatcgc 1760041 aattccggcc attacagcaa caagcatgtt cataacagtt acagatacag cggactgtac 1760101 cagattttcc tgtttctcta aataagcgct atacgttacc atgacagata caccgacact 1760161 taataagaaa aaggattgtc ccattgcata taaaatggta ttggcatcaa ttgcagttaa 1760221 atcaggcatg aggaaaaatt tgattccttc catcgcgcca tcaagtgtaa ccgaacgcac 1760281 cattaaaatg atgaataata gaaaaagcgc cggcattaat acttggcttg ctttttcaat 1760341 tccgctgctt accccttttg caacaactaa aattgttacc accataaaga gcagctggcc 1760401 tcctacagcc aaataaggat ttgaaatggt acttgcaaat atcgtatcaa aaccagatgt 1760461 ttgcgataaa ccgccagtga agccttttat aatataaatt aaaatccatc cgcctacgac 1760521 actgtagaaa gatagaagaa taaagcacgt caccatgcct aaataaccga tccaatgcca 1760581 cttcgttcct ggagcaagtg ttttatagga ctgaacggca tctttctgtg ttcttctgcc 1760641 tatgatgaat tcacctaaca ataaaggcag tccgattaaa accgtaaata aaataaaaat 1760701 aagtaaaaat gcgcctcctc cgctggttcc ggcaacatat gggaatttcc atatcgcacc 1760761 aagcccgata gctgatcctg ccgcggctaa aataaagccg agcttcgaag accattgatt 1760821 tgcttccttc accgtatcac tcctatttga tctaaccatt ataaaggttc attgtaagaa 1760881 tatcttccta tatagtcaag aacattttaa ttagtttaca tcatatatct atagacatct 1760941 gccaaaaact aatattgaat tattcagaaa attatttata ataagagaat gttatgaaat 1761001 ttgtaagaat ttctgctgaa gttcttgata agtgtgttag gagtgttttt atggacatca 1761061 ttagaaaaat aagccatttt gcaggacaaa cctttggcat atgggtcatt gtttttgcag 1761121 tgctgggatt ttctttccca tctttattta cgtggatcag ttcttatatt acgatttttc 1761181 tcggcattat catgtttggg atgggcctta cactgcaagc cgatgatttc aaagagctgg 1761241 tcagaaagcc ttggcaagtt attattggag taatagctca gtatacgatc atgccgctcg 1761301 ttgctttcgg cctcgcattt gggcttcatc ttccagctga aatcgcagtt ggtgttattc 1761361 ttgtcggctg ctgtcccggg ggaactgcat ctaatgttat gacattctta gcaaaaggaa 1761421 atactgccct ttctgttgcg gttacgacaa tttctacctt attggcacct gttgtaacac 1761481 cgttgttgat tatgctgttt gccaaagaat ggcttcctgt ctcgccgggg tctttgttta 1761541 tctcaatctt acaggcggtt ttatttccga tcattgcagg tctgattgtc aaaatgtttt 1761601 tcagaaaaca agtggcaaaa gccgtacatg cccttccgct tgtttctgtc attggcatcg 1761661 ttgcgattgt ctcagctgtc gtcagcggca atcgggaaaa tctgcttcaa tcggggttgc 1761721 tcattttttc agttgttatc ctgcataacg gtatcggtta tttactgggg tttctttgtg 1761781 caaagctttt aaaaatggat tacccgtctc aaaaagcgat tgcaatcgaa gtcggcatgc 1761841 aaaactccgg gcttggggct gcacttgcca cggctcattt ctcaccgcta tctgccgtac 1761901 caagcgcaat attcagtgtg tggcataacc tttcaggttc tatgcttgca acatattggt 1761961 caaaaaaagt gaaaaagaag caagctggat ccaaaagcag caatctatca ctttaaatat 1762021 gcatcaaaaa gggtacatca ctttatcgtg atgtaccctt ttttattatc cttctaataa 1762081 aagctgttca ggatcttcca gtaaattttt gattgtcacg aggaaaccaa ccgcttcttt 1762141 accgtctaca attcggtgat cataagataa agcgatatac atcatcggac ggttttcgaa 1762201 acgctcttca tcaatggcta cagggcgcag ctgaatctta tgcatgccca gtataccgac 1762261 ttgcgggctg tttaaaattg gagttgacat caatgaaccg aaagtccctc cgtttgtaat 1762321 cgtgaaggag cctccctgaa gctcgctaag ggttaattta ttgtttcttg cttttttcgc 1762381 aagctcgccg atctcttttt cgattcctgc aaatgtcagg cgatccgcat cccgtacaac 1762441 cggaacgaca agaccttcat cagcagcaac agcgattccg atatcgtaga attttttaac 1762501 gatcaactca tcgccttgaa tttctgcatt caacagcgga tattttttca atgcagccac 1762561 gaccgctttc gtgaagaaag acataaagcc gagcttcact tcattttgct caaaaaattg 1762621 atctttgcgg cgttttctga gattcatgac agccgtcatg tccacttcat taaatgtagt 1762681 cagcatcgct gatgtttgct gtacctctac aaggcgtttt gcaatcgttt gtctgcggcg 1762741 tgacattttt tgcacttcaa caggtttgtc aaagctttgc tgtgcttttt gagcctgagg 1762801 ctgctgcttt tgctgaggag ccggttttga tgccggtttt tcgtacgctt cgacatcctg 1762861 cttgcgcact cttccaagcg gatctccagt tggaacttga gacaggtcaa ttcctttttc 1762921 tctcgcaagc ttacgggccg acggagaagc gatcgttctt gattttgctt cagattgtgc 1762981 ttcctcgctc acctcttgtg cagctggttc agcctgtttc tcttctttta cgctttcctt 1763041 gctttctgtt ttctctgtag gagcaggggc agaactttca cccgcgcctt ctgaaatcgt 1763101 accgataatt tctccgacct ggacggtatc acccgaatct ttcaatacct cttgaagtac 1763161 acccgattct tctgctgtca attcaacatt cactttatcc gtttctagtt caagcagata 1763221 ttcaccctgt tctacatagt caccaggctg ctttaaccat tgggctattg ttccttctga 1763281 gattgattct gctaattcag gtaccttaat ttccgccatt ttttcatttc ccccttagtt 1763341 tttgcgagtc aagctatcag atacaatacg ttcctgttct tttttatgaa ctgtcggatc 1763401 tccctctgca gggctggatc gtcttcttcg tccaatatat tgaacgctta ctccctctgg 1763461 tgcaatctct gtcaaatacg ggctgatata accccaagcc cccatgttct gcggctcttc 1763521 ctgcacccaa acgatttctt tcaggttcgg aagttttgca aataattctt tgactccttt 1763581 tgccgggaat ggatacagct gttcgattct cgcaatgtga agccactctt taccgtcttc 1763641 taacttatta aaatgatcgc taatgtctat agacacttta ccgctggata atacaagtct 1763701 ggttactttt tcatagtcat gagaaagtcc cgactgttca taaacaggct ggaagcggct 1763761 ttcgctgagc tcctgcactt ccgacaccgt atttgggttg cgaagaaggc tcttcggcgt 1763821 cataatgacg agcggtctga tttcttcacg aagcagcatt ttagcctgtc ttcttaaaat 1763881 atggaaatac tgtgccgcgc ttgtcaggtt ggcaaccgtc cagttgtttt ccgctgcaag 1763941 ctgcaggaat cgctcaattc ttccgcttga gtgctcaggc ccctgtccct cgtaaccgtg 1764001 cgggagcagc atgactaatc cggatttttg gccccatttc gcgcgtccgg cagaaataaa 1764061 ttggtcaaaa tacacttgag cagcgttggc aaaatctccg tactgtgctt cccacaaaac 1764121 aagcgtttcc ggtgaatgca cgttatagcc gtattcaaaa ccgagaaccg atccttcaga 1764181 cagcgggctg ttatgaacag caaatgatgt gctgcagtca gataagtgat gaagcggcac 1764241 aaattctttg cccgtctcac tgtcatgaag cacaaggttt ctttgggcga acgttccgcg 1764301 ctcggaatcc tgtcctgtta aacgaatcgg tgttccgtct ttcaaaattg aagcaaacgc 1764361 gagtgattct gccaaagacc attccacttt tctgtcatca tcgaacgcct tggcgcgtct 1764421 ttctaaaatg cgctttagct tgccgaaaac attaaatgac tccggccagt tgatcaattc 1764481 gccattcagc ttgcggagca catcaaaatc aatcgaagtg tccacatctg ggaaaccgtt 1764541 tgatacaggc tctggaagtt caatttcaca agcagtgtgt tcctttttag acggaacttt 1764601 ctgatatgca tcctcaatgc gcttcgttac cgatttttcg atgttttgaa cgacttcctc 1764661 ggtaaccacg ccttctttta ccagcttttc agcgaaaatt tgtttgacgg tcggatgctt 1764721 tctgacagca tcatacagca ttggctgagt ggttgacggt tcatccattt cgttgtgtcc 1764781 atagcgtctg tacccgatca aatcaatcag aaaatccttg ttgaatgttt ttcggtattc 1764841 gaccgcaaac ttaacagctg aaagacaagc ttcaggatcg tccgcattca cgtgaacaat 1764901 cggaatttca taacccttgg ccaggtcgct ggcatatttt gtcgatctgg attcagcgct 1764961 ttctgttgtg aatccgatca tgttattggc gataatatga atcgcaccgc ctacttgata 1765021 cccttttaaa gagcttaaat tcaatgtttc agctacaatt ccttccccag ggaatgcagc 1765081 gtctccatgg attaaaatgg ccagcgattt tgtttcatct tgtaccgggt atccgctttg 1765141 tgttcgcgtt tcctgtgccg ctcttgtgct gccttcaaca atcggattga taaattccaa 1765201 gtggctcggg ttgttcgcta acgtaatgcg cgctgatttt gtttcagcgt cttgaagctc 1765261 ccgattcgcc cccaaatggt atttgacatc ccccgtccat ccgtagctga ttccaatgga 1765321 tccctcagac ggtacaagat ctttgttcgg cgcatgctgg aattcagaga agatgatttc 1765381 atacggtttg ccgagcacat gtgccaagac attcaggcgt cccctgtgcg ccatcccgat 1765441 gttgacactt gtcgtgcctg atttgacaga ttgtgcaata atgtcatcaa gcactggaac 1765501 aagagcgtcc agaccctcaa tggaaaagcg cttctgcccg acgaatgtgc ggtgcaaaaa 1765561 ctgctcaaag ccctctactt ctgtcaatct ttccagcaca gctgacagct tttcagctga 1765621 gttcttctgg aacagctcgc cagattcaat ctttcttgtc agccactcgc gctctttgaa 1765681 gtcatgcaca tggtcaaatt caaaagagat ggttctttta tacgtatttc gtaaatactg 1765741 aatggcttct aaaccgttcg aaatgttttt aggagcgtct ttgcagatga cagacgcagg 1765801 tattgctttt atttcctctt ctgttagccc gtaatcggat aatggaaaaa gttcgctctt 1765861 tttctcatcc tttctgagcg gattgacgga agcgttcaaa tggccatagg ttcggatatc 1765921 ttctgcaagt ctgactgcgg atgcgatctt ttgaatcaga tcggctgtaa cacgtccctt 1765981 ttcttttgtt cccgaggcct cttttatatc gcttggcgga gcaccgagct cgtcgaacat 1766041 ttccttcaaa tccgggtcaa tgctgttcgg atcctgggta tactgatcgt aaagctccag 1766101 cgcatagccg aggttcggac cgtaaaaatc ttcccaattc attcgttgtt tcatactatt 1766161 ttgaaacatt tgaatattac ccccaactta aataatcaag tgattgattc actatcttga 1766221 aataactttc gaacgctgtg tccaaaatta tgtaataaaa acgcttccaa cgatatttta 1766281 ccactgtttg caatttgatt ctaccttgat tgttcacaaa atagtaaaaa acctttataa 1766341 aaaacaaaaa atttaatcat tcgaaaaaac aaacgccaaa aagcatagga ttaagggcta 1766401 tcctatgctt ttatgaagca gttttttcag cagcggatac aaaacatccg gtagctgatc 1766461 aacatccggg acaaatatac tgaattttcc gtacatatcc tggatcgtct tcatttgcga 1766521 ttcttctatt tctgagttgg agagaaaaac atttatcact tctattcctc tttttcgggc 1766581 ttcgataacc gcctcacttg tatcaacgat cccattttgt tcgtagccaa atgcggccgg 1766641 ctctccatct gagaaaacaa ttaagaactt ttgcgcctcg ctgcgatgca gcattttttt 1766701 cgtcatctgc ctaattgcgt acccgtcacg gttatcttct tctggctcaa gctgcataat 1766761 ggccggtcca gaatcttgtc ttaatgatga ttggaaggga ataaccgtat tgaaatagtt 1766821 tggctggctt ttttcggttg catcatttgt gtcctcccaa aaaccgacaa tctgatgcgg 1766881 aaccgctacc gatttcaacg cttcgtgaaa cagcacgatt cctcgttttg tttcgtccat 1766941 tttgtcgaac atgctggcgg aacaatcgac cagcaatgta aaaactgcgt cgatttctga 1767001 agatggttct tgctttttgt agaacaggcg cggatttcgc tcagtgaagt aacgaagaag 1767061 cttattgttc agtctcccgg catgaaggtc tgttctcggc aatgtttttt tatgctccag 1767121 cgttttttga atcatttgtt tcaaacgctt ttgatacgat tcaatcgttt ttgcctgctg 1767181 tttataagaa agctcttctt cactggttgc cggctgcggt tctttataaa ttggaaatgc 1767241 atatttattt tctttgccgt cagccatacc cgctccgttc ggctggtctt tttgggactc 1767301 cagcgcttcc agcttggaat agtctttccg tttcgtttgt ctggctgatc cttgaacaga 1767361 gccaagggcc tgatctccat cgtcgccttc ccttgaagca tcttttccta aatctgattt 1767421 tgcgccgtgt tcaatatcaa attgaaggaa gcttttagac ggtgcttctg tttcccggtg 1767481 ccatgtcggc atttcttctt catggatatc ctcatcaccg tctgattgtt ttggaagcgt 1767541 gatgtcatca ctcagcttcg gcgctttttt ctcttcttca aataacggct gttctgcagc 1767601 ttttgcgtaa tcaagctcag gcaaaaagaa gtaggtgttc aacatgtctt tatcgagtac 1767661 ctcttcaagt ccgtccatga ggtcctcaac aattttcaga acctgccgtg tcgaatctgc 1767721 ttcatacaca cgcaagagct gctgctcaat aaacgggcgc atcagatcga tatcttcacg 1767781 catggatgga agggtctcga gcggcgattc cgctgtgagc ttgaaataga tcgcgcaaaa 1767841 gagcgcatcg gtaaaaatgc ttcgttccaa atttaaggtc agctgggttg agaaatgttt 1767901 tctgtacatg tcttttcgct tcgcaaatac atgtttcgta cccgggcgct cacgtttgat 1767961 gcattcttcg atcctaatgt cttcaagcag cataaagagc tgcttggcaa aacttttaaa 1768021 cgtaagatgg cgatggatat cattcaaaaa gttcgcaaac tcatgcagcg agctatatct 1768081 tgttccgact gaacgcaggt agacgtcgct tttcagaccc gcttccatgt cctcagctgc 1768141 cctgtctttc caaaagtggc tcatatagat tttcttttca aatggattgt aataggactg 1768201 aacgccatac tccacttcta ccgcttcact cttggtgagt gttttggcca aatcagtcag 1768261 catcataaat aaaaatgaat caatcgtgct gtcgttaaat ttgataaatt tcatcgcagc 1768321 cccctcattc aaacagagtt tctgcaatat ttcggacagc cgctttttcc cgatcatcat 1768381 caagcttttc tacaattccc cgctcaatgg cacgacgcgg cggaatataa gcagctaaat 1768441 cacatgtatc gattaaagct ctgatggatg ccgcttcttc agacacctgt ccgttattgg 1768501 cctgaacgat caagtcagag gaaagcgtga taaatctgtc aatcaatttc tcgtctttca 1768561 aggctgactg agacatgagc acttgtttca gcagctcgcc tttaatataa ggcacatcaa 1768621 tgatgacaaa acggtttttc aacgcttcat tcagaggaac agttccgaca tagccttcat 1768681 tgatggctgc aatgactccg aaaccgcttt tagcccgtat gacctcgcct gtaaacggat 1768741 ttgtcatcat ttttctgtaa tctaatacac cgtttagaat aggcagtgtt tccggcttcg 1768801 ccatattgat ttcatctata taaagaaaat ggccttcctt cattgccttt gtaacaggtc 1768861 ctgaaacaaa ctcgattgtt gcctggccag attgattttc aatcgtttta taaccgacca 1768921 atgcctcagc gtccaagtcg actgaacagt tgacgctgtg catcggttta tgaaaatagc 1768981 tggacaatgt ttctgccagc tttgtttttc ctgaacctgt aggccctttc agcaggacat 1769041 ttttccccat ggctaatgca ataatggcgt caaataaaat ggcttcatcc tccgcctcat 1769101 agcctgatgt tcctataagc gattgaaact ctggggaaat aggctgctct ttatatgata 1769161 aaagcttttg ttgtatatct tccggcaatg ttaagtgctg tagttgagtt gtcatagaca 1769221 gattcccttt cctattcata ttccattaac gagtatacta aaaaagcccc tgtatgctca 1769281 atacaaaagg gcctggatga tattactgct tctcgttatt tcccaaaagg gctccgcaga 1769341 caatacgcgc accggaattg ccgcttgggt ttgtcagata atcgtccgct tgttcatgaa 1769401 taataaatgc acttccgtcc tcgtcgagaa tatttagttt acttcctttt ttcagtgaag 1769461 tgtcaggcgc attcattatg acatctacct ttccatcagc accgacttca aggttcggca 1769521 gatctccggc atgatgcccc atcggattat taaagccgtg ttctttgttc agtggattaa 1769581 agggaccgcc cgctgattca aaatccggcc tgacacaaga acctttctca taaatatgaa 1769641 aaccgagaga agcacctgga cgcaggctgt ttgcggaaat atgaatatcg aggccttcat 1769701 catctgattc tttgatctct ataaaaccga ctgctttccc ttcacgattg accagctgga 1769761 catgatgacc aaacgctgac gtttcaacca cttttttttc cggcacccgg ttaggagggt 1769821 ctggaggttt tttttgtccg catccggcaa ctcccagtgc cgtcagcatc atcaacagca 1769881 agagacggtg catactgtct cccccttgtt ttttctaaca gtgtggtcaa tcattgtctg 1769941 gtataaacaa aaaagcctat aaaaggcttt ttgtcatact catttttaaa aataacttct 1770001 tgcgcccaag taccgctgtt tccaatacga attgctgaga ttggaaatgt cgacgcccga 1770061 tgagcttgca tgaataaaat caccgccgcc tagataaatc cccatgtgag acgggccgga 1770121 tttatatgtg gtaaagaaga caaagtctcc tactgacggc tggctgactt tctgcatgac 1770181 attccaatac cctgccgtac tcaatcttga tatagatgat acattattaa tgaggtaata 1770241 aatgaagccg ctgcaatcaa aaccggcagg cgtgtttccg ccccatcggt aaggcactcc 1770301 gacatatttt ttcgcttccg ttatcattct gtcaatcttc gaacctattt gaatgtttga 1770361 ccctgagtta tcttttggct ttgttggctt tgtcggattt gaaggattag attttgatgc 1770421 tcccgaaata gtcagaacct gcccgatttg caacacatcc gatgataaat tgtttttatc 1770481 acggatgctt tggacagtga ctccgagccg atttgcaatt ttccacagcg aatcgcctgc 1770541 ttttaccttg tacgtcgttg tttttgaggg attggagttt gacggctttt tggaaccgct 1770601 gtttccgttc ttaggtgaac tgcttccttt tattttgagc acctgtttag gataaagtgt 1770661 atctgatgtt aagccattta aggtttttaa ttcggctaca gtcatattta agctgtttgc 1770721 gattttccac agtgagtcac caagcttgac cgtatatgta ctttttgaag aacctgaaga 1770781 attggaaccg ctgtttttct ttgatccatt tgatccgctt gaactgcttg tccctttgat 1770841 cttaagcttt tgccccggac gaatcaggtc actgctcagg ctgtttaagc ttttaagctc 1770901 agaaacactc attttatgat ttttagcaat catccatagg gaatcaccat atgcaactgt 1770961 gtatgttgat gttttgcttg aattagatgg ggatgtcgtg ctttttttgc tgctttcagg 1771021 aaccttaaga ctttgtccga cataaagcac cgttgatttc aatttgtttt cggatttcag 1771081 agctgatatt gtcgtatcat actggcggga aagtttccaa agagagtcac cgctttttac 1771141 ttttatcgtt tttgcttccg cgggtgctgc ggccatcgac gacccaacaa ctgcagaaac 1771201 agccaagccg gctacaatct tctttttcat tcattcaacc tcctaaactg tttttttgca 1771261 aaaacagcta gtattttgtt tccaaaaatg gcacacaact gttttatcgt caatttttca 1771321 gcaagttaaa cccttttcaa acatttggcg cagcattttc agcatcgttc gacctttaaa 1771381 ccttcaaata aacatctaac attttacata agcacgatat gtttttcgaa agtctaagga 1771441 actatttaag cgagggtaaa aatgatggtt ttctattgat gaacgaagca gtttctcctc 1771501 ctttcttgtc tatttttcta atcaattctc tatcggcgtg tcaaatccct tcctctgcat 1771561 tcttatgaaa tggcaaaaag cctgttcttt cgataagaac aggcttttac actatgcatt 1771621 tgctgattga gttttttgtt ttacagcttc aagaatgctg tcggctgctt ttttagagcc 1771681 gcctgccgct ttcagtgatt gtccaatttc ttttgccttt tcagcatacg aacgattatt 1771741 cattacttct tgtatcgtct ctttcagtag gctttcagac aattcttcct ttttaattac 1771801 ttttcctgcg ccgacttttt ctacctgatc tgcgacaaca aattggtcgc ctcccatcgg 1771861 aatgacaacg agcggggttt caaaatacaa accttcactt gtgctgttca ttccgccgtg 1771921 ggtcacaaat aagctggctc ttttcaagat ctcaagctga gggacatacg ggcgtacaat 1771981 gaaattctcc ggaatgtcgt ttaactcact tgttttaata tgcttgccga tggaaagcac 1772041 aactttaccg tcaaagtcct tacacacttc aaggcattga ttaaaaaact gcttttgatt 1772101 attaaaaatg gttcccattg aaataaacag cacgttttca ttgtcaatct gatcaaatgg 1772161 gaaatcattg tttccggctc tttctgtaat ggaaggaccg acaaatacat atcgctcgcc 1772221 aaattgctca gccagtggct gaaatcccct tgatgtaaag acgattgtca agtcaccatc 1772281 agctaaaaaa acatcaaatg gcttcttgat ctctgcttga aaatcagcat ttaacgtttc 1772341 tgcaagctgc tggtatgatt cataatgagg cgaatcttca agtgatcctt tcatgtacgc 1772401 tcccatcatt tccttcgcaa attcctcatt catcgcaaag gttgtacaca atgaaaatct 1772461 tggcagcttc agcatgttgg caatgacttt acccgcgaga agatggtgat catatatgac 1772521 ataatcatac gattcatgtt tgacttcctc ataaatatga gtcgcgatat ccttacaggc 1772581 tttcaaaaaa gcgcagagca tttctgtgaa atctctttct tcatcgccgg ttgcgttttt 1772641 cccgaagtaa tctcctctga aatcatgata ctcacgaaac tctatatcaa gagctgtgat 1772701 tttttcttta tattccttca ctgcgtagta cgtaatgttt tctccccggg atttcagctc 1772761 cttcatcaca ccgatagagg gattaatatg cccttcaccg gggaaaccga tcattaatac 1772821 attagccatg cggcagcacc cttcctttga gaatttatgt aatattttat acggtactat 1772881 aaatgcataa acaggtaaag tatttcactt aattaatatt catcatatat aacttttcta 1772941 ccagtttata ttccctgtct tcaagacaaa aagcattcag cttgaagcga atgctttaat 1773001 aaagatgcga attcagtcat tttgtctcat gataggattc ttaatcaggc cctttttatt 1773061 atttttacgt tcttggtgaa attaacggat ataatacacc gtctttggca aacgacatct 1773121 tccctgtttc ctctgaaacc acgagcacca gtgcatccgt atagcccgac ataccaagag 1773181 ccgcccggtg ccgggttccc aaatggatat ccacttcctt cgtcgtcagc gggagcacat 1773241 tggctgctga cacgagtttg ttttccctca ctaataaagc gccgtcatga agagggtttc 1773301 cgggaaaaaa gatgctttca attaatgaag agctgatctc ggcgtgtagg gaggtgcctt 1773361 tttgaataaa acgttcaacc gggtctgctc tttcaatcac aattaaagct ccatgcttat 1773421 gttccgataa ggctttaatc gccttggcca gctcaataaa tgccggcgta aattcctcaa 1773481 tgtatgattg caaataaaag gaggatgcaa tcccctgcat gtcctgaaaa acgtgcccca 1773541 aatcatctaa ttcacaaagg agacactggt ctttttcgtg aagcgttttc aagattagag 1773601 atgcatcacc taatatttgc tctaagtaca cctgtatttt ccccttgaac gcattttctg 1773661 atatctgctc atagcgcata gccttcatct cctgtttaaa tttccaactt ttcacgaatg 1773721 cttatcttat tgatgcacat tctattggta aaggagggat gtaaagaatg gaaatcgaaa 1773781 gaatcattca gtatatttgc acctttttag gcgtgatttc gctttctttt atttatgccc 1773841 aaatgtttag aaaaacgaaa ccgacaaaaa aagaataggc ccggcgttca ttgcttttta 1773901 tacataaaat gttataattt ctctcgttat gaaaaagaaa cggagatcaa tgtatgaaag 1773961 aaactcaaaa cgcccgggaa aaaatcaaac agctcttgca cattttaata ccgatattca 1774021 ttacccaagc ggggctttct ctgatcactt ttctagatac tgtgatgtca gggaaagtca 1774081 gccccgctga tttagctggt gtcgccattg gctcaagcct ttggacccct gtttacacag 1774141 gacttgcagg tatattaatg gcggtcaccc cgattgtcgc tcagttatta ggtgcagaga 1774201 aaaaacagaa gattcccttt actgttttac aagctgtata cgtggccgcg cttcttagca 1774261 tcgccgtttt agtgattgga tatgctgcag ttgaccttat tcttggccga ttgaaccttg 1774321 atattcacgt gcatcagatt gctaaacact ttttaggctt tttatcactg ggaattttcc 1774381 ctttatttgt ttacaccgtg ttgagatcat tcatcgactc attaggaaaa acgagagtca 1774441 ccatgatgat tacactcagt tctcttccaa tcaattttgt attgaattat gtatttatct 1774501 tcgggaagtt cggaatgccg gcacttggag gtgtaggcgc gggactggca tccgcgttaa 1774561 cttactggtg tatatgcatc atcagttttt tcattattca taaaaacgca ccgttttctg 1774621 aatacgggat ttttcttacc atgtataagt tctcttggaa agcatgcaaa aatttgctca 1774681 aaatcgggct gcctattggg ttcgccgtgt tttttgaaac gagcattttc gcagctgtca 1774741 cgcttctcat gagccatttt catacagtga ccatcgcgtc ccaccaggca gccatgaatt 1774801 ttgcgtctct tttatatatg ctgccgctta gcgtgtccat ggctctaaca attgttgtcg 1774861 gatttgaagc gggtgcagcc cgttttaagg atgcacgctc atatagctta atcggcatca 1774921 tgatggcgat cggcttttct ttgttcactg ccgcctgtat ccttttattc agagagcaaa 1774981 ttgcgggcat gtacacttct gaccccgatg tgctccggct gacacagcac tttttaattt 1775041 atgcgctatt ttttcagctt tccgatgctg ttgccgcacc gatccaggga gcactcagag 1775101 ggtacaaaga tgtgaactat acgcttgcgg ccgcttttgt ctcttactgg gtcattggcc 1775161 ttccggtcgg ttatatggtc ggtacgttta caagcctcgg tgcattcggc tattggattg 1775221 gattaatagc gggactcgcc gccggagcag ttgggctgtt tttcaggctg gcaaaactgc 1775281 aaaaacgtta ttcgcaaaaa caacacattt aaaagaggtg atcaatcatg gcaaaaaaca 1775341 aaaaattatt cgagtatctt tcccagcatg cggaaaccat cagttcaaca tggtatgaaa 1775401 caatcgagga gactgatccc aattccattt atgcctcaac agaccctgtt gtcattcaca 1775461 atttaaagag ccagaatctt gcctttaact ataaaataaa ccgtattttt atagatgatg 1775521 aggacgtata cttgcctata ctgaaagaat gggcctttga agtcacacag gatcaagagc 1775581 atttaaaaac tcctatccac tatattattc gggagtttgt cagagtgaga gatttatatg 1775641 tttcttatgt gaaagaattt gtccatctca atcagaatac tgtgaaaagc gaagaagccg 1775701 aagacctgta tcacgccctt ataaaagcgt ttgatcttgt gattcatatt tttatagaag 1775761 aaatgtacaa aaacacaagc cttcagcttc aggcccaaaa agatatgatt actgaattga 1775821 gcgctccggt catcgtgctg tttcacagcg tcggactgct gcctttaatc ggagatattg 1775881 atacagtccg cgccaagctg attatggaaa acacactgca tcaatgtgcg aaaaaaaagg 1775941 tgacacaact gtatattgat ttgtcaggag tagctgtgat tgatacgatg gttgcccatc 1776001 agctgttcag tctgattgag gcgcttcgtt taatcggtgt ttcttcaact ttgtctggaa 1776061 tccgtccgga aatcgcgcaa acagcggttc agctaggttt gtctttcgaa ggtatttcct 1776121 tgagatccac tctcgcttca gctattgcat cggacttaaa attaaaaaag gtataaggct 1776181 taaggcctta tacctttttg attaatcatt ccattgatac gtccaatata tttcttcttc 1776241 aaaccatgtt gccataacag gttcattatt tttcaatttc tcttcaagct ctctgagcat 1776301 gccttctgtt tgtgtgcggt gagctcttaa cgcattcatt ttaatatcag ctacttcttt 1776361 gatatcaagt acgacatcag cttcgccgag aacctcttct ctgttgcggg taatggccat 1776421 gcagattgta cgcggacggt cttctttctt tttgcggtat aatgcacgga taaccgcttc 1776481 cccgcatgca tcatggtcag ggtgcacacc gtgtccggga taaaatgtga caattaaact 1776541 tggttttaca tcatctatga tctcttccat gatatcagct aaatactcat cgtcttcaaa 1776601 ttcgagcgtt ttgtcacgga gtccaagcat ccgaaggtca ttgatatcca tttctttgca 1776661 agcgttgatg agctcttgtt ttcttagcag cggcaacgtt tcccgattcg cgaaaaatgg 1776721 atcgcccata tttctgccca tttcacctaa agtggcgcag gcatacgtaa cgggaatgtc 1776781 tttttttctg tttaaggcaa tgaggcctgc cactccatat gattcatcat cagggtgagg 1776841 caggattact agtacatgtt ctttcattat tattcaccct tttctttaaa ctgtgaacgg 1776901 tttttcgctg atttgcagag aaatagccag tttaccgccc ggcaggtgtc ccgccattaa 1776961 taaacggttt tcttcatcta ccgtgtattc agtcaagcct tcagcataaa tccagccttc 1777021 ttctgttttc aagccaacgc ggtaaggccc gttgcctttg atttttgcct gatgataagt 1777081 gacttttgca ttgcgaatat acgcaacaac cgtcatgttc ttttcattta agtgcgctga 1777141 ataagaacct gtggtggttt ctaaatggat atatacaggg cggtccgcat atcgttctaa 1777201 agatgcttgc acatcttctt ttatgatcgc tttcatgatt gctcccctct ttcttctttt 1777261 aaatactctg cacgttctgt atgtaatttg accagctgat atttcacagc cggttcgagc 1777321 tgtgaattca caatgcgctg aatcgcggca aaatattttt ccagcatcgg ttttcggagt 1777381 cttggatgtg ttcgtttatc caagagctca agatcaatcg cctctgctac cgcttctgcg 1777441 tcatcatgtg cgagagatcg gttattccaa agtgaagcat aggctttcac tatctcttta 1777501 tcattgtcca tcgtcttgct cctttatgtc ttacatacat gaaatgatta tacataatat 1777561 atgcatcagc tgaaaagcca aaggcctcaa tggctttttg acgcccgttt ccacttcact 1777621 tgtgaaaacg taaacaagag cagcgcagcc catatacagc tgaatgtaaa agccttcgag 1777681 cttgaaaatg gctcatggta aacaaacagc ccgatcagca gggtaatggt cggcgcaata 1777741 tattgtaaga taccgacttg atacagtggc agccgtttcg ctccttccgc aaacaataag 1777801 agcggcaaag ccgtaaacac accggccaaa aagagaagca gccacgtccc tccgctttct 1777861 gcacccgctg gctgaacatg tccgctgaac agcaaatacc ccaatgcaat gggcataatc 1777921 atgaatgttt ccagcgttaa accgatggcg ctcggcaggc ttgttctttt tttgcttaac 1777981 ccgtacagcc caaagctgaa tgcgagcaga agcgcaacat aaggaatgga gccgtattgg 1778041 aacgccgaga tgatgacacc ggctgccgca atcgaaacgg ccactaattg caggcgattc 1778101 agtttttcct ttaaaaataa aatcccaagg agcactgata caagcggatt aatgtaatag 1778161 ccaagactag cctcaagcaa aaagccatgg ttgacagccc atatgtatac aaaccagttg 1778221 atcgaaatca ggatagaagc aagaaataaa gagaggatcc ctccgttctt tttcagagag 1778281 cgcaactcct gccatcctat tttccattgc cgcaagaaaa aaagtacgat acacataaaa 1778341 acaaaagacc atataatacg atgagccaaa atatcaagag ccggcagctg ttcgagaagc 1778401 ttccaataga gcggaaacag gccccacatg ataaatgaaa cggctgtgta aataacgcct 1778461 ttttttgttt ctgcatgttg cattgatatc cctgcctttc tttagagcat cttatattat 1778521 atcacgtgaa agatctggtg ggcatatact attttgtccg tgaagaaagg atgtgaagac 1778581 aatgtttgag tggaacaagt actttccttt ccacaatcaa ttttctaaag aagcattaaa 1778641 aaaagctgat ccgaaagaag ttgaaacgta tgtcaatcgt gtgatggaaa gtgtgttcgg 1778701 cagtgattat gcggctcaat ttcctttccg cgatcctctc ccccaaaaag aacatcccgc 1778761 caaacctgat gcaaaacctg atgtcaaacc tgatattgat atattcgaaa cagcagacca 1778821 tgtgtttgta aaggtgccaa tcagcgaaga atggctggaa caagtgagaa tcaaacacac 1778881 atctcacgaa ttatggttgg aaaacctccc aagagcagat catccgaaaa aagtaaacct 1778941 tccttgttta gtcaaacgca aaggaacaaa agccgtctat aaggatggcc ttctggaagt 1779001 catgtttcaa aagcagcaag actacaatat gtccgaggta gaaatcatcc gataaaaaac 1779061 ggcctgcaat cgatgcaggc cgttttttat taatagaagc cgggatatcc cccgtatggc 1779121 acgccggcac caaaaccgta cggtccgcct ccatatccat aagggccagg aggataggca 1779181 tagggacgag aatagttaaa cagcgcactc ccgagaaaac cgcctaataa accgccgact 1779241 agaggagcgc caaacaaaaa aggactacgc gccggatatc cggctggacc tgggattccg 1779301 cgtaaatacg aatgatgagg gtacatgatt ttttcctcct ttatgtctgc ctatacgtaa 1779361 agtattcagc aaggaagaaa aacgattggg ctacggactg tctatgattg ttacatcaca 1779421 agccctgcca ataacacaca gccgagccct gtaaccgaaa gaactgttgt aagcagcgtc 1779481 caggtttgaa atgtttcttt catgctcaag ccgaaaaatt cctttaccat ccaaaatcct 1779541 gcatcattta catgacacgc aatgacactg ccggctcctg ttgcaagcac cattaacgca 1779601 gggtttacac tgccagcctc cataagcgga gctgccattc ccgctgtggt aagcgcagcc 1779661 acggtagcag agcctagaca cagacgcaga accgcggcga tggtccatgc aacgaatagc 1779721 ggcgacatgt ttgtttgacg gaaaaaatca gcgacataat cgccgactcc gccgtcaatc 1779781 agcacctgtt taaacgctcc tccccctcct atgatgagca gcatcatcgc aatttgcgaa 1779841 attgattctg aaatagatct gccgatttcc tgcatagata ttttacgggc atatcccatc 1779901 gtatagagtg caagcaacag cgaaatgagc attgccgttc ccggagtgcc gataaattct 1779961 ataatgtctt ttccttttga atgttcactc aataataaag aaaaaattgt tgccattgcc 1780021 ataaagataa ccgggaataa agacgtgaca gcactgatcg caaagcccgg tgtttcatcc 1780081 agctgaaatt ctttccttgg tcctaacccc gataggtttc catgcttttg atacgcacca 1780141 ggaaaccgtt tcatcgcaaa tttattaaat aaaggcccgg caatcacagt tgtcggaaca 1780201 gcgatgatga ttccaaaaag cagcacctgg ccaatatggg caccatatgc aactgagata 1780261 gcagttggag caggatgcgg gggcaaaaat ccgtgagtaa catttaaggc ggcggccatc 1780321 gggattccca gatacagaaa aggcattttt aattctttag caatcgcgta aacaatcggt 1780381 atcaacagaa caagaccgac ttcaaaaaat agggcaatcc cgatgataaa agaggcaacc 1780441 acaaccgccg cctgtattcg tttcctcccg aatttgtcaa tcagcgtaat ggcgatccgg 1780501 tagccgcccc cagcatctga gacaagcctc ccaagcatcg cgccaagtcc aaacactaaa 1780561 gctaaatgcc ccagctgccc gccaattcca gtctcaattg aaagaacaat tttattgata 1780621 tccattccaa gtccgatggc tactaaaaat gaaacgacaa tcagtgagac aaaggtattt 1780681 aattttactt taataatgag aaataacaga atcagcactc cgacagctac aattaaaatc 1780741 ggcatggtac ccctccaaaa gtgttttata tgattctcgc gacaatgttt tggcgctttt 1780801 catgcctaga tgaacagaaa gcgctttcat taataactaa aaacgtcttg gttatatgat 1780861 tgttatcttt tgatcaacta atatgttcat actaatctcc taatcaatga ctgtcaatcg 1780921 tttttatgag cttgtctcga ttacctaccg cctaacccaa tgatttatta gttatatgtt 1780981 gattaacttt tggttatatg ttatgttttt taaagttgac tgccaatcat tatatctctc 1781041 cattgtctgg aagcaaatga gacaatatga gaacagacgg ataacaactt cataagagga 1781101 ggagtacaca tgccattatt gcgttttgat gtaattgagg gccgtgatga aaaatcgctg 1781161 caattgttat tagatactgc tcaccaagcg atggttgaag catttggtgt tccggaaaga 1781221 gaccgttatc aaattgtcca tcagcatccc gcaaacgagc ttataatcca ggatgcggga 1781281 ttagggtttc agagaaccaa ggatatggtc atcattagca tgacaagcaa agcaagaacc 1781341 gaaagccaaa aggaaaaatt gtatgctctg cttgctgaaa ggctagaaaa aaaatgcgaa 1781401 atttcccctg acgacctcat ggtatctatt actgagaatg gtgacgcaga ctggagtttc 1781461 ggtctcggtg aggcgcaatt tttgaatgga aaactataag atttcgtctc cccacaaaaa 1781521 aaagaagaga gagctccaaa gaagctctct cttttttcat aaatgcggaa gtcatcagta 1781581 tagaagcatc cagcaatacg aaaaacctgg atctcctttt atatccggtt taaatgccaa 1781641 ttggaagctg actgggtttt ggctgaaaat ataaaatttt gctgatttgc ataataagat 1781701 acatcataat ccccatttac aataggttgg atgttatagc ttattgatca tttcctattt 1781761 tatatatccc cttcatatgc acatgacatt tttgccaatc cggaaatatc agtctgacaa 1781821 atataaaaag tcatgtaaac gggtgtgaac cgtacttaca tgactcacca tggaaacaaa 1781881 ggctcttttt caggtgccgc tttccttatt tctcttcttc acacactgtg tcaccaggct 1781941 cgcaaaattg atcggcccat gcctgcattt cttgaaatac agcttgaagc gctgttcctt 1782001 tttcagtcag cgtgtagatg actttgaccg gcgtttcagg gagaacctgc cgttcgacaa 1782061 tctcgttttg ttcaagctcc ttcaagcgct ctgccaacat tttttggctg atcatcggta 1782121 ttgtttccgt tatctcttta aaccgtttcg gcccatccat tagcacatgg atgatcagac 1782181 cgttccatcg ttttcccagc aatgagaatg cggattccat tttagggcac atcgtatttc 1782241 ccataagtct tcatcccttc atctattgat tgacatgtat tcaatgatcc attacaataa 1782301 tctttcaagt tacatttagt aagcttctaa cttttctatt atcataccac gtttatccga 1782361 aggaggaaac actatgacga atactctgga tgttttaaaa gcacgtgcat ctgtaaagga 1782421 atatgataca aatgccccga tctctaagga ggagctgact gagctattag accttgccac 1782481 taaagcgcct tctgcttgga accttcagca ttggcatttt acagtattcc acagcgatga 1782541 atcaaaagcg gagcttcttc ctgtagcgta taatcaaaaa caaatcgttg agtcttctgc 1782601 tgttgttgcc attttaggcg atttaaaggc aaatgaaaac ggtgaagaag tttatgctga 1782661 attagcaagc caaggctata ttacggatga aatcaaacaa acattgctcg gccaaatcaa 1782721 cggtgcttac caaagcgagc aattcgcacg tgattccgct ttcttaaatg cttctttagc 1782781 tgctatgcag cttatgattg ccgcaaaagc aaaaggttat gacacttgcg caatcggcgg 1782841 atttaacaaa gagcagttcc aaaagcaatt tgatatcagt gagcgctatg ttccggttat 1782901 gcttatttca atcggcaaag cagtgaagcc tgcgcatcaa agcaaccgtc tgccgctttc 1782961 aaaagtatca acttggctgt aaggatatga aaaaccttag tccgaaatcc ggactaaggt 1783021 ttttttatac aatcgcctct ttgtaccatt cacgagcctg ttcagcttca tgctgagtca 1783081 gctgatggcc cccgtcctgc cagtaaacgg aggctgatgc cccgctgtca cgcaaatagc 1783141 ggtaaagctc ttctgattct tccttcgtgc aaagaggatc gtatttcccg gcaccgataa 1783201 aaacagggag ccccgccata tcaggcagct cgataccccg aatcggaacc attggatgat 1783261 gcagaatagc cccttttaac acatctttat aatgaaaaag caggcttgcc gcaatgtttg 1783321 cgccgtttga ataaccgact gcaatcactc ggccgcgatt aaactgatgc gtttctgcag 1783381 cctcgtcgat aaaatctttc aattctcttg tccgcaccac aagatccttt tcatcaaaaa 1783441 ctccttcact cagacgtttg aaaaatcgcg gcattccatt ttcaagcacc gatcctctga 1783501 caccaagcaa atgggcatca gggtctataa accgccccaa tgaaagcaga tcgtgttcat 1783561 taccacccgt gccatgcaac agcaaaagta cgttgtcaga tgttcctttc tcataaatat 1783621 gcttcattat aaattccccc ttttaaagtt caggtaaaat gtctgtaatt tgttgtctat 1783681 gtttctccag ccattcaggc agttttaagg aagtccctag ctcagcaaac gtttcatctg 1783741 tcataaagcc cggttcatct gtggcaattt caaataagat accgcctttc tccctaaaat 1783801 aaactgatgt aaagtattcc ctgtcgagaa tttctgacga aggcagatgg ttttcagcaa 1783861 taatcggcag ccatttcgcc tgttcctttt tcttagtccg aaacgctaca tggtgtaccg 1783921 taccatatcc tccgactcct cttttttcag gatgtaaatg gacatcaatg acaccgccga 1783981 ccgccgctga agatgccagt ctgacaatct ggtcttcttc ggccactttg gtgtatccaa 1784041 agctttccgt taacaattgt atggtcgcct gcgggtcgta ggaatatagc agcacacctt 1784101 tcattcccgt aattgcttca tttgttgtga tcccgtcagg cgtccactcg cttttgccgc 1784161 ttttcgcatc ctccatgatc gccagcggaa ggtcttctgt atcatcaaaa ataagacctt 1784221 tttcaccaaa caacgttttt tcctctaggc tcagcccgct tttctcaaga cgttccttcc 1784281 aaaaagacag ggagcctgag ggaactgaaa agtacacccg gcccgcttgg ccttttccta 1784341 ccgttccctg tccgcttcct tggaacggaa aaaaggtcat tattgtaccg ggatctccgt 1784401 tttgattccc aaagtaaaaa tgatacgttc cgggatcatc aaagtttact gtttttttaa 1784461 cgagcctgag cccaagcact tctgtataaa atcgcaagtt ttcttgcgga tctctggcga 1784521 atgctgtgac atggtgcaat ccttctgttt tcattttctc actcctattt atctcgattt 1784581 caagatattt attattttaa acctttattg aaaaggatgc aaaccatgtg ttttgattaa 1784641 ataattgaaa aaatcatttt tttctaataa ttatcttgtg atcttttctt acaactgcta 1784701 ttatagtgag cattatcatg tttcaggagg aaagtaaatg gttaaaaaag cacttattgt 1784761 tattctcatt cttttgccat tcgttcagct cgcgcttttg ccgcttgtga atcgaataga 1784821 accgattatg ttcggcctgc cgtttttcca cttttggctg ctgctgtgga ttattgttac 1784881 gccgttatgc tcgtttggca tttatcagat gcaaaaaaaa gatggaggac ttgaataatg 1784941 caagggaatc tgactgcact tctcattact gctattattg ttttaaccgt tgtctgtatc 1785001 ggctttctcg ccggaagaga caaatcctca cgtacttctg tggaagaatg gtctgtcggc 1785061 ggcagacgct tcggcggtct tctcgtctgg tttttagtag gcgctgacct ttatacggcc 1785121 tatactttct tagggttgac cagtactgct tttacaggcg gaagtgttgc atttttcgcc 1785181 attccttatt ctgtgttggc ctactttatc gcctacttct tcttgccaaa actttggaaa 1785241 gttgcgaaaa ttcataaatt aacaacactc gcggattatg cccgggaacg ttttaacagt 1785301 aagcttttgg caagcctcgt tgccatcgtt ggggtactca tgcttattcc gtacatatgc 1785361 cttcagctga gcggcattca agacacgctt caggttgccg gcactggcta tattaacgta 1785421 aaattcgttg tgatcatttc atttattctt gttgctcttt acacattctt cagcgggatt 1785481 aaagggccca catatacagc catcattaag gacattttag tatgggtcat tatgctgttt 1785541 atggtggtgt ccctccctct cattcatttt aacggctgga cgccaatgat tgacacgtta 1785601 gtgaaggaag cgccgcaaat gctgacgata ccgtcagaag ggccaaaagg cattccttgg 1785661 tttatcacag catctattgt ttccgctctg gcacttttta tgtgggcaca tgccgctaca 1785721 ggtgttttca cggcgaaaag cgctgatgca gtaagaaaaa acagcatgtt tttgccgctt 1785781 tataatatcg tgttaatttt ggttattttt cttggcttta tcgcctttct tgttctgccg 1785841 gaagatacaa atccaaggct ggcgctgctg catttgattc aaacatctta cggcggcgtg 1785901 gcacaaggct ttgcatatgc cactatcgct cttgcttcat taataccttg ttccattatg 1785961 gcaatcggcg catcgaattt attcgccaac aacctatacc gggatttgat tcatccgaat 1786021 gtgtcgcaaa gcaagctgac tcttgtcaca cgttcaatgg tgtttgttgt catcggtctt 1786081 gcgctgctgt ttggaatgct gttcccgact gccttagtga cacttcagct attaggtgta 1786141 tccggtatgg tgcaaatctt ccctgcgatt gctgtcagcc tgttctggaa aaaccaaacg 1786201 aaagaagcaa cggttatcgg attattagcc ggcctagcgg taacgtttat tgtgtatatc 1786261 actcaatccg cacatggcat ttatgaagga ttctggggat tggccgccaa catgatcgct 1786321 gtggtcatcc tgaatccgct gttcgttaaa aacgcgggat ccaatcctgt cattgaaggt 1786381 ttatttggca aaaaacaaga cgctaatcca aatcaaaagg gcgcataaaa aaaccatacg 1786441 cggcagccgc gtatggtttt ttttacattt cttttttcag tgtttcaatt gccttttcca 1786501 tttgcgtatc attatcagac agcttctttt gaagttctat cattaatttc gttgttgtat 1786561 cgccagtcag tatgcctgtt tcattcagct tctctttttt ctggaactgt ttgacgacag 1786621 atacaaaatc ctggtcatac atactgttaa cctttacctt gtaaccaagt gctttgagca 1786681 ttttctgagc cactttgacg tttgtgcctg tatcacctga tttgtacgtt ttatctgcgt 1786741 ccaaatacgg cagcttcgcg taatcaggca gctctgcttt cacttgaggc ttgatgcctt 1786801 ttttgtgaat ccattcgcca tcagcagtca gccatttggc aactgtcagt ttgacggtag 1786861 agccatcatc atattctttt gccgtttgta ctgtaccttt gccgaatgtc gtctcgccga 1786921 ttaacggtac gtttgacgat tcatgaaggg cagcggccat aatttcggct gcgcttgctg 1786981 taccgtcatt tactaaaacg acggtcggct tggtcacttt ccgttctttt tcggccttca 1787041 tgacttcttt tgaaccgttt ttgtattcaa cctgcatgat gtttttccct ttatcaatga 1787101 acaggttgct catcgtaatc gcctgttcca ttaagccgcc cgggttgcct ctcaagtcta 1787161 aaatatagcc tttggcgcct tttttctcta aactgtcaat cgcatctgtc agctctttag 1787221 ctgttgtttc agagaaagaa gtgatttgaa tttctccgat gttgttgtct ttcatctctg 1787281 aatagacagt ctctacagga atggtatcgc gcttaatgga aagatcgata ttccccactc 1787341 ccgctctgtt cagttcaagc ttcacctttg tgcccttttt gcctcggatt aaagcgacgg 1787401 cttcatttac attcatgcct tttacgcttt ttccatttac cttaatgatt tggtccctcg 1787461 gtttgatacc ggctttttca gcaggtgaac ctttaattgg ggatacaata aggatttctc 1787521 cgtctttctc ctctacttgg gctccgattc cttcaaaaga tgctgaaatc gtctcgtcga 1787581 atgatttcgc ttgctcttga tccatatatg tagaatacgg atcatccagt gattgaatca 1787641 ttcctttaat tgctccgtct actaatttgt catcatctgt tttttggtaa taatcacttt 1787701 tgatttgctc atacgcttta tttaatttgt cgaacttgct gtctcctgtg cttgctgatt 1787761 tttggcccag gatactggaa ttgcccgtaa taaataaagt aagcgccgaa gcgacaactg 1787821 cagtgatcag cacaataaaa aacagtttta attgccgttt caattaaaca ccaccttttt 1787881 cttcttacat tattatcatg gacgaattct tattcgtcaa ctcggagcag aaatgaaaga 1787941 gaaacgccct tcttttgctt ttcataaacc tatgtcttta tacgacatat gataaggaaa 1788001 aaggaggatt cgatattgag ccgatattta gaaatgctgt ccttattcgg tgtcgcaggg 1788061 gcgcacccag gcgggctggc tttttcaaaa gcggtcttgc aaaaggctgc accctctccg 1788121 gatcagccga ttcttgatgc cggatgcgga acagggcaaa cggcggctta tttaggacat 1788181 ttgctgtatc ctgtaacagt cgttgataaa gatcctatta tgcttgagaa agcgaaaaaa 1788241 agatttgcga atgaagggct tgccatccct gcatatcagg cggagctgga acatctcccg 1788301 ttttcttctg agtccttttc ctgcgtcctg tcagaatcgg tcctcagttt ttcacgcctg 1788361 acatcctctc ttcaagaaat ttcaagagtt ttaaaaccca gcgggatgct gattggtatc 1788421 gaagctgctt taaaaaaacc aatgccccct gcagaaaaga agcaaatgat ggatttttac 1788481 ggatttactt gcttacatga agaaagcgaa tggcataaac tcctaagatc ctatggcttt 1788541 caaaaaacag aagcgatgtc acttcttccg gaagacatgg aatttgaacc aaccacagaa 1788601 atggatttat cgcaaacgat tgatcccatc tattacgata cgcttcaaac acattatcag 1788661 ctcatgcagt tatatagtga gtacatgggt cattgtattt ttatcgcgta caagtaaaac 1788721 ggcgtatcgc cccctgtttt cgtccaacct ttttttccta tctatcatat gctgatagaa 1788781 agtcaggata ggaggggaac aatattggag agatattatc atctttgcaa aaaccatcaa 1788841 ggtaaagtcg tcagaattac agagagaggc gggagagttc acgtcggcag aattacccgt 1788901 gtaacaagag acagagtttt tatagctccg gtcggcggag ggccaagagg tttcggttac 1788961 ggatattggg gcggttattg gggatatgga gcggcttacg ggatttccct cggtttaatt 1789021 gcaggagtgg ctctggctgg tttattcttc tggtaagcat agaacaaatg ctagattcac 1789081 cagacacaat gaagcccgct tatctagtgt aagcgggctt ttcattttaa attttcttca 1789141 ctttttcaaa gtactcttca agcgttaaat cattatcttg gatgaccttt gcggcttttt 1789201 tgcctacata gcgcagatgc catggctcat attcatattt cgtgatatct tctttatttt 1789261 tcggatagcg aataataaag ccatatttat aagcattgtc ctgcacccat ttcccgtctg 1789321 ccgtgcttcc gaacgcttca tttagctcaa agccattgct ccggctcgaa atgtccatcg 1789381 caaggcctgt ttgatgctcg ctttcacccg ggtaagcgac cgcttccttt gccttccttt 1789441 ccccttttag gcttacttca ttgtcaaaaa tgactttctg tctgtcatac gaacggtacc 1789501 ctgagacagc tgccagttca tagccttcct ttttggcagc atcgaacatt gtttttaatg 1789561 cgtcggccgc ttcttttctg atgtaacgtt tttgaatctt ttcttcaaaa gaaaactcta 1789621 catcaggtat gacaagatcg ctaggttcat agtttccggg cagtgcatat tgtttattga 1789681 caagcgcgag tatattttct ggattttgaa tggtttccag accatcgact tttttaatat 1789741 cattgaaata ctggctttcc aatgaaaact cactgttttg agtgtttgat tttttgctgt 1789801 cagctgtttt ttgttctgtt tgctttgttt ctgctgtggt tttcgtatcc ttttgagcat 1789861 ctccgttcga catgctgcag ccggctccga ctattgccgt tacactcaga gcggcagcca 1789921 gtgagaacca tttaccggac tttttcatat tacattacct tccttttatc aatcgtttcc 1789981 gcatgcataa agaagaggct gccggcaccc agcacgcctc ttgatatatt ttattgtgat 1790041 acggaatgta aagccacttc tatcatatca tgaaatgtcg tttgacgctc ttccgctgtc 1790101 gtttcttctc ctgttaatac gtgatcactc acggtgagaa ttgacagggc ttttcttccg 1790161 tgcttcgctg ctaatgtata caatgcagtt gtttccattt caacgccaag cacaccgtat 1790221 tttgcaagtt tttcaatttg cgaatcgtca ttgtagaact ggtcagctgt aaatacgctt 1790281 cctacagtca ccggcacacc tttatccttt gcggcatcat aggcattttt taaaagctcg 1790341 aaatctgcgc aaggcgcaaa atcaacgctt ccgaaagcaa ctctgttcat ttgtgaatca 1790401 gttgaggagg tcatcgccaa aatgacgtct cgcactttga catctttacg aatagcgccg 1790461 caggaaccga ctcttattag attttgcaca tcgtagcttt gaattaattc attcacataa 1790521 attgaaatag acggaactcc cattcccgtg ccttgtactg agattttttt acctttatat 1790581 gtacccgtaa atccatacat gcctctgact tcattgtagc attctacatt ttcaagatac 1790641 gtttctgcaa taaattttgc tctgagagga tctcccggca aaagcacagt atccgcaatt 1790701 tgtccttttt cagcacctat atgtacactc atctcatatc ctcctgtaaa tctaaattat 1790761 catccagccc gtccatttta caacgaatgt catgatgaaa caaacttcag cattgattat 1790821 aaaggaatat atcgaaaaaa gaaatgttcg aggatctgtt aggcacttcc tcagaaaaac 1790881 ggataatcgg ggtgttaatt tgaaaaccta accgcaggaa ggaggggtgg gacatgggta 1790941 aaaaacatcg taaccggatc accggccaaa aaaagaacaa tcatatacct gaaaaagata 1791001 tcattgcagc tgaagaagca cacgggaaag aatattccgc tgccaaacgc aagccttaaa 1791061 actgcagaaa actgcgggtt tccgcagttt tcttttcatt atgtcgtttg tacaatcaga 1791121 cgattgattt tcctccagcc ggcgggaagc agttgataat atgttttccc ttttctgcct 1791181 tcatcaatca ggatcacgtc ccctgtggcc atgaatcttg catcataatc actcggaaca 1791241 gtgtcgaata cattaaacaa agagaatgct cttttcagca cgtcttgatg atcgctcccg 1791301 ttcagttcag ttcgatagac ggctctgtag cccttttttt cgccaaaccg gggtgtctga 1791361 aatattgtca cgtcatagga acaagacttc tttttaaaca cggataacat catcaagatc 1791421 ccctcccttt tatttcttta acatattggc gtttttgctg tgttttcctc tctctatttt 1791481 tgtcgaaacc gcttaatctt ttcgtcaaaa ccttttacta ggaaaaacag aagcaagccg 1791541 aggctaaagc ctcctaacac gtctgtcaca aaatgaaccc ccagatacac tctgcttatg 1791601 ccgactaaaa cagcaattac accggctatg atatatacca tttttttatg cttagacaaa 1791661 aacgggagat gtttcactaa aaagtaagca ataacaggat agacacaagc agcattcatg 1791721 gaatggccgc tcggaaaact gaaggatgat tcatgaacca gcggtgcaaa atcaggcctc 1791781 actctttcga tccattcttt taagactttg tttaacagcc gatctgtgcc gaatactaag 1791841 agcatcaaca ggccgtccca tgtttttctg tagaaaaaca tgcctgctcc aatgatgaca 1791901 attagaggga gcagaaaaga agaagcacca agatgcgtga tccccgtcat gacttcatta 1791961 agccatggct gacggatcaa aacagctgcc ttgcttattg cttcatctgc agattgaaca 1792021 gcatttgtat gaatggccgc agctagaatt aaaaagaaaa gaaacaaact aacgggcttg 1792081 tacaatttta accacctcaa ttttcacaga agtcatagaa catgaataat aaaaccggag 1792141 ctgaccgctc cggttttaag cctcactcat cttcatccag ctcttcatct atcatacatt 1792201 tttctatcaa ataatcaaag gtaatatcag cgatttcaaa cagctcatcc tcactcggta 1792261 tgtagccccg tcttgcaagc tctctgtaaa aaaattcagc gatttcttcc gtatcaatca 1792321 caagatctat ttctttcatc tccgtaccgc ctcctttttt atgttttatg aaaaaacagg 1792381 ctgaattata cccggtgttc taaacaattc tttcagtcat atattgaata aaaaacgagc 1792441 catgggaggc tgacgctatg attgctaaaa tgatggaagc actggacgga gaaagatttg 1792501 atatcataat ggaaaaaacg ctcaaaggaa tgacgcgtgt gatgatttgg ggctgtctgc 1792561 catatttttt atatgtcttg atccgtatgt tcacaaatta actgaaatgc tcttttaaac 1792621 tttccaaaac aaacatcatc atgtctttat attcttcatc ctgaaacatt tcgtacagaa 1792681 ttttgtagtc attataaata tccagaagct catcaacaat tgacacagca aggatgtgaa 1792741 gggtatcttg atcttcatca ccgccttcaa actgaagaag agcagacgat gcgatatctt 1792801 cgccgatctc atggccagtt tctccgacat aatggacaaa caacagctga tgcacaaact 1792861 ggtccatttc atattttcta agcaccagcg tgagatcctc ttcctccgtt tcaagccact 1792921 ctccatcctt taaacgggtc agctcataaa tgatatcttc ccagccatct tctaaatatc 1792981 tccaaatttc tgttctatgg ccgataatgc gaaagagttc ttttccataa tctttaacat 1793041 aaacaacgtc cccaataagg aattcatact caatatcaag cttctccatg tcgacaatga 1793101 caccctcata atctttataa agctgaatag atgattcaaa gtataaaact tcgttatgat 1793161 tgacttcata aagatagtgt ttatcaattt ggtgtacttt tgtgatggtg ccgactgttc 1793221 catacataat gacgactacg atatccccta cttggaattt cggtttattt tgcttcatgg 1793281 tgtctccccc tcgccgcaac atttctcata cgctatcgta tgccgggtga agccaattcg 1793341 catgggcatg aaaaccaaag gaaatatcca attatggtat gggtatggac ataaaaaaat 1793401 ccgcagtgat ctgcggatga aacagctatt atctgccgtg cacttcagac tcgtattgat 1793461 cccaagcttc atcaaacgtc gccatcgtgt gaaggtaatc agcattcagc tccaaatatg 1793521 aactgatttc atgataatcg gttgatgttt ttggaaagct gtgatcctca tacgcctgat 1793581 tggcaaattc actgatgctg tccttcggct tagggtgtct gtatttcaat aaatagtgat 1793641 aaaaggattt catgggtttc ccctcctgat gtctgtcttt tgttgttcta ttatacagtt 1793701 caagtgtaaa attacaacaa aagaatactg aaacatgact caggagaagt caaaatagtt 1793761 gcgtttcaaa attctttctg tctccatgag ctgctgatat gtcaggcttt caggcagttt 1793821 ttttgtttga attaaaagca gctgatcctc aatctcttta accgtgtttt cctcttgata 1793881 ggtcataccg caggaagaac ataccatggc aggggtgtct gtcagttcta tagccctcgt 1793941 tccatcaggg agctcccagt acaccgtgtt cctgccgggc accgcttcga gctcgccgca 1794001 ccattcgcat gttttcatga agaatcccct ccgcattcag tctctttctg ttttttctgc 1794061 tgcgccaaaa atttcttttc tttgagctga tctcttttct cacgccgatc ttttaatgtt 1794121 tcatgctccg gatttgcgat gtatgcctct ctccttttga ttctgtctac attttcaggt 1794181 gtaaacgaaa cttctttgtc agcaaaaatg gcactcagcc cgatcggctc ctttttgtca 1794241 gcggtttcag ggaaaacgga ctcaaaatag gcgtctgcct gattggggat ataattctct 1794301 ggttccggat atgacgtaat cacaccttca aaatttctta agatcacttt gtcaggactt 1794361 tgtgacagga catagtttgg ctgcagggcg attttacctc ctccgcctgg tgcgtcaacg 1794421 acaaaggtag gaaccgcata gcctgaggta tgacctctca gcccttcaat gatctccaaa 1794481 cctttggaaa caggagctct gaaatgccct attccttctg acagatcaca ttggtaaata 1794541 taataaggac ggactctgat ttttaccaag tcatgcatga gctttttcat aattggaacc 1794601 gaatcattaa tacctgctaa tacgacagcc tgatttccga ccggcactcc cgcgttcacc 1794661 agcttttcac atgcctcaac ggattcttct gtcatttcga tgcttgtgtt aaaatgggtg 1794721 ttcagccaga ccggatgata ttttttcaat atctcgcaca gatgatcggt aatgcgctgc 1794781 ggaaagacga cgggagctct tgttccgatt ctgatgactt ccagatgcgg aatgctgcgc 1794841 agctctttta aaatatattc taaaatttgg tcgttgatga gcagcccatc accgcctgaa 1794901 attaaacaat cgcggatttc gggtgtttcc cggatataag caattgcagc atcaagctgt 1794961 tttttgggga cgcccattcc gatttgtccg gaaaagcgcc ttcttgtgca gtagcggcag 1795021 tacatggaac attgattcgt gacaagaaac agcacacggt cgggatagcg gtgtgtcaga 1795081 ccgggtaccg gtgaatcttc atcctcatga agcgggtctt ccagatcgta ttttgttttg 1795141 tgcatttctt cagaaagcgg cacagactgc atgcgtaccg ggcatctcgg attgtcgggg 1795201 tccattaaag aagcatagta aggtgtaata tttaagggga tcgttttggt agaaattctg 1795261 acgccttcct cttcatcctc ggtcagatta atgactttct ttaaatcatc taacgttctt 1795321 acagtgtgtg tcagctgcca aagccaatcg ttccatttct cttccggaac gtccttccat 1795381 aactcgatct ccttccaatg ccgtttcggt ttataccatt tgtttttcaa acgaactcct 1795441 cctcgcgcat attttgactt acagttgctt gcaccaaata ttcatgtttt caaggccttc 1795501 ggctataaag caattattga tcagccttcc gccatactga taacctgaat ggtacaacac 1795561 agcattcatc ccaaaagacg aagcacgggc gagagaaaac acatgaacga tatcctctcc 1795621 agccatttct ttttctaacg cctcgattaa aaagcttgtt aacgaatggc cgcgatattc 1795681 cggcagcaca gcgcaatcgg ttatttctgc atgcccaagc tctggattga tttctgcgct 1795741 tgctgcgctg atcaggcggt catgatcaag catgatataa tacaccgtat ttgcattcat 1795801 cgtcttttca atataagcgg ggtcaaatac cggggttggg tacgtgcgga atactttttt 1795861 atacagcatc gatagctggt acatgtcgtt tgtttctgct tttctcatcg taaaaacggg 1795921 tgtactgtcg ttgcgaagac ggggcgctgt gcgatatatg gcttcgatga tctcctgttc 1795981 ctctgtataa gaatctgttt gtctccggct ttctgaaagg taacgtacca tgacacaagc 1796041 cgaatggccg agataatagc cctttagata gccctccggc gcaaataatt gtttggcaag 1796101 gatcggctca tcatgctgct tcgcatagac aatgattttt tctgcattct cttcttttgc 1796161 cgctgccacg atatccggca gggccttctc aatggctccg tcataacgaa ccactctgat 1796221 tcgtttatta aagccgtcat ggtccaaaac tgctgtgaca ccgctactct ttattgactt 1796281 gagcatccgc atcctcccca tctgtatgaa ggccgcacca atccatgaca aaaagtgcaa 1796341 taattttagc agattctatc atggcttcaa cctcaatgta ttcattggcc tgatgagccg 1796401 tttttgtttc ccccggcccg aaaacgatca ctggtgtatc tcctgcatgg tacaaaagcc 1796461 ctccatccgt tccccacggg gaagcctcaa taatcggctc tgtctgtttc attttttgat 1796521 aggctgattg cagcacagaa attaaagggt gatcatcagg taaatcattc ggcagccatt 1796581 gagcgccaaa ccattcgact tgtacgggat ggcgtttaaa ccattcgtca tggtattcta 1796641 aatccttcag ccagttttcc aattcaagtt ttacagcttc tggtttctca tggggagcaa 1796701 ttccgcatct cccttctatg acgacacggt ctgcaactga agatggccag gcaccgcctg 1796761 agatggtgcc gatattcacc ggtaccggta ttgggatatt gtcatacagc ggatctgaaa 1796821 ttctcgcatt gcggactttc tccagctctt gtatcgctgt gataacgtgc atgctttttt 1796881 caatcgcgct taccccttca tagcgtgtgc ccccatgtgc ggataatccc ttcacagtga 1796941 tccgaaacca catcgaaccc tgctgcttaa taaatagttt catattcgtc ggttcaggaa 1797001 tcagcgcccc gtcagcacga tagcctctca tgatggcgga aagtgtaccg gcgccgccgc 1797061 actcttcatc tacaacactc tgaaacaata catctccctt cagtttgaca tcgcaggcgt 1797121 gcagggcttc taaagcaaaa agaagggctg tattgcctcc cttcatatcc gttgagccgc 1797181 ggccgtatat tttaccgttt tcttcgacag cttgatacgg ttcatacttc caatccttta 1797241 cgcttccttc aggcacaaca tcgatatggc cgttcaaaat cagggacctg cctccgccgg 1797301 ctcccgtttt tttagccacg atattcgggc tctcatgaaa atcggatcgg ttagatttaa 1797361 agtagggatg ctgttttaat tgctttatgc ttggctccca tacatcaatg tccatatgaa 1797421 attgccgcag cttttcaagc acaacagctt gggcgttaaa ctctgacccc aatgtgcttt 1797481 tttccccaat cagccttttg agaagacgaa tggctttggc cgaatgctga tcaagccact 1797541 cgattacttt tctttcaatg tcttgcatcc tcattccccc tcttaagaaa aaggcatatc 1797601 tattttgatt tcagcttctg tcagcctcgt cacctcatcg attgtcgagc cattcatcag 1797661 ctcttttaaa atgaagtgat ggctatcgac ctcaagaacc gctttttcgg taataatcaa 1797721 atctacacag cctgcagcag ttaatggcag cgtacatctt tctgttaatt taggccttcc 1797781 cttttgatct gtatgactca tgacgacaac cacttttttc gctttttggg caagctccat 1797841 cgccccgccc ataccaggca ccttttttcc cggaacaagc caatttgcca aatctcctga 1797901 ttggctcacc tgcagggcgc ctaaaatcgt aatgtcaatt ttgccttttc tgatcatcgc 1797961 aaaagacatg gttgtatcaa aataagaagc cccttttaca gcgcggacag gatatcccgc 1798021 ggcgttgcat aaatgcgcat cctcttctcc cttttcggga ctttctccaa tgccaaggac 1798081 accgttttcc gcttgaaaca tgacctgcat gtcaggcttc aaaaagttcg gtaccaagga 1798141 agggataccg ataccgagat tcacaatcat gccctgctta atttcagtag cagcgcgttt 1798201 tgcaatctgt tctctttctg ctactcccaa gcccatttcc acttcactcc ctcgcttcgt 1798261 acaaccccct caacaaaaac ccccggtgtg acaatcattt cttcagaaat ctcccccatc 1798321 ggaacgatac gctcagcttc ggcaaaggtt ctcctggcgg ccattgccat aagcgggttc 1798381 atattgcgcg cggttttgtc atacgttaga ttgccgaatt catctgcaat gtaagcattg 1798441 atgaaagcaa aatcagcagt cagcgcctct tcaatcaagt atcgttttcc cgccactgtt 1798501 acgatgtcct ttttttcgca aaccatttga ttatcaatgc ccacgtcggt taaaataccg 1798561 ccaagccccg ctccgccggc gcgaatccgt tccgcaagcg ttccctgagg tgaaaattga 1798621 acctctaacg tcccctctgt catctgtttt ccggctactg gattggaacc gatatgcgag 1798681 gcgatcaggg ttttgacccg ttgattaaca ataagcgggc cgattccgat atccgggaaa 1798741 ccggcgtcat tgcaaatcac agtcaaatcc gttacaccgc tgtccaatat cgcttcaatc 1798801 aatgaaggag gcgacccgac tcccccaaaa ccgccaaaca tcagaaccga tccatcccga 1798861 acatctgcaa ttgctgtgtc aatgctgatt gctttttgaa atggcgccat ttaatgtcaa 1798921 tcctttttta agtttttttc gaccgctgca actgtttctg aaaaaataga gataagctct 1798981 tccatttcac cgtctgaaat agtaaaagga ggagcaataa tgacagcatc tccttctcca 1799041 ctgtctattc cagctttgga aggataaaca atcagcccgc gttttttcgc ctcgctgaca 1799101 ataagctggg ttatcgcctg ctctggcgga aacactttct tcgttttttg gtctgccaca 1799161 aattcaatgc ctaatagcag tccttttccg cgcacctcac ctataatgcc gctttgagat 1799221 gccgcctcat caagcttctt cttcagcaca gcgccctttt tttctgattg tttgatcaag 1799281 ccgtgcttta acacatatcg caaaacttca agagcagctt tggctgaata gggatgtgca 1799341 ctatatgtgt gaccgctcat aatcacacct gacccttgtt ttatggtttc aataatagaa 1799401 tcagatacga cggcagcagc aataggtgca taccccgcac cgagtccctt ccccagtaca 1799461 gcaatatcag gtacggtatc ccaatgctct gtcgcgagca tccttcctgt tctcccaagc 1799521 cccgtcatca cttcatctgc aataaaaagc acatcgtgtg tgcggcatac ctcacttaat 1799581 ctctcataat atcccggagg cggagtaatc gctgctcctg cagcaccaat aataggctca 1799641 gccacaaagc cggcgatgaa ttggcttccg attcttttaa tcatggtgtc cagttcatca 1799701 gctgcagtct gaacaaagtc ttcttccgtc tcgtgattca gccgataaat atgtggagct 1799761 gagatagctg gataccgctc aatgagatgg gtgaaccggt atctcctttc ataaaaacca 1799821 gacaatgaaa gcgctcccaa agttattccg tggtaactgc tccatcgaga caaaaagatg 1799881 gatttttgtg tttgcttttt ttcctgccaa tactgaatgg cgattttcat agctgtttct 1799941 atcgcttctg atccgctgtt gacaaaaaaa gaccaattca catctccggg cagctcctgt 1800001 gccaagagag cggctaattg ctcggcgggc tcactcgtaa actgtgagcg gtaagcaaaa 1800061 gacacctgat caagctgttc tttcagcttc tcagtcacat cacgaactcc gtggccgata 1800121 ttacatgtca ccgcacctga cgagccgtcg agatattttt ttccggtctg atcataaaca 1800181 tatgaaccct tcgcataact gacaaccgga taggccgagc taagctctgg cttaatcaaa 1800241 taactgctca tgctcccacc tcaaaacccc ttttaccata ttgtatgagt gtccaaatgg 1800301 cggcatgacg ttccccgcaa aaactttttc acataaaaag agccttccta ataaggaagg 1800361 ctcttttgaa atttcagcat ctagcaaata aaagcggctc caacaataat taataaaatg 1800421 aacaagacaa caattaacac aaatgtattt gtcccgcagc caaatccgta accgtaccca 1800481 gagtatccat acatgctgtt ttcatccttt cttatcacga tatacgacat tttatgcggg 1800541 ccaagtccca aatggtttgt gcaaacgcct atttcatgta aggaaataat gaaatacagt 1800601 atgcacccgc tcatattttt taaacgtcag cttttcgtaa aactgagttg caccgtcagt 1800661 gcttgcagcc actaagtagg ctgcttccat tcctagtgat ttggcgatgg acagcatttc 1800721 tttcactaag atactgccgt agcccttcct ttgaaactga tctaaaattg ccacttcttc 1800781 gattttagcc gttttctctt gatgatcgat aaacagctcg ccgcacccaa tgggaacttt 1800841 ctgtgcctgg tcgctgtaac aaacaacaag aatgattata tctgcttcat agaaaggata 1800901 ttttcttttt aatttttgtt cagcgattgc ttctccaata taaatggaat cgtaaatttt 1800961 cataatagaa gatccgtcgc taagactttt tgccgtcccc catgcggtta aaggatgtcc 1801021 catctgcccc ttccagtcac taagcttcat gtcatatagt agctcatcct cgacgacaaa 1801081 accgcttttt acaagtgact gcttcaaacc gagcggaaaa acatgctgcg gcgacgcttt 1801141 taaatggaga taattcgcat caagcagctt tggtacggag ggtaaaaagt taagtaaccg 1801201 ctccaatgga aacgtatcat ggagctgaac aaagttatga gaaaaaattt gcggaagctg 1801261 cggatctctg tatacgctgt aatgatcaaa cgatgccgat tcagacgtta acaatatata 1801321 ttgatgttcc gtttttgaat aatgtcctgt catgaacgtc tcctttttat gacctatacc 1801381 tttactctgt tgcaatattc aatttcttta taatctcatc gtacaccgga taaaacggct 1801441 ttccaattgg aaattgctga atatttcgga aagaagcgga gattggcttc tgatgtaaaa 1801501 aaaacttcct tgttacttgt tcactaatcg ggtgaaagac gccgtttaga aacaaaaacg 1801561 gctcgcgttc gatgaaaaac agacgtcggc caggcggatt tttgatcaat tcagatcgtt 1801621 tccacgtaat cggcggccct tccggaagcg tctccatctc ttcttttcca attgtcacta 1801681 tgtcttttct ttgaaattga taaaattgaa acgcatactg gtccacaatt cgcctttttt 1801741 ttccggcttc gatataaaat attgcaggat ggtcagcttc ctttactaaa atataattcg 1801801 gaatgtttaa aattttgcca atcctatatt ggaataaata tgggtctgga acagcgacag 1801861 tccgatttag atacaaaaaa ccccactttt ctccaacagg atgccttaca ccctgatcaa 1801921 aaaaatacac attttgatct gaacctttta caaaagagcc gtcaatcaaa tcggcgggca 1801981 gaaaccgata tgcattttga aatgaatctg gggttttata ggttgtgtct aatacttcat 1802041 ttatcggcag aaatggggta aagttgttga gtctcgccca aaaaattgcg tcgccatgat 1802101 tccaatgctt catatcatca tcccagtagc ctccaaattt atggtgaatg agattaagta 1802161 acgaacggcg atgcataact gagcaatgat caacttgaaa agcggcctga tcaagcactg 1802221 cattggcatt tctgtagaaa tgtgagattt cctctcccct ttcgtttaca tgtacaactt 1802281 tttgttttga atagaccgcc tgcgcttcag gcttatgtga aaactcttgc accatacggc 1802341 tcagccgctc aggatgataa acagtgtcgt cagtaagata ggaaatgtaa tcgccgtctg 1802401 caaatgggag cgcactgtta attaatgtgg cataacgggc tgtttttaat cgatctgcag 1802461 gatgcacgaa actgttatga tattgaatgc gccggtcatg gagatacttg tgaatcaccg 1802521 cagttgtttc tgcattcgaa tgatcatcca tgataaaaag ctcccaaaga tcatgcgttt 1802581 gctgtatcac gctttcgatc gctttttgca aataatcggg tttgttgtaa cttgttaaaa 1802641 taatagacac tttctctccc atctataccg cctcccgccg tcaaacataa aaacggctcc 1802701 gcagcaagca gagcctctgt catcatttaa aaagcacccc agcttacaac acttgagagt 1802761 gaaacatgag atctcgtgtt atttaacggg ttttggaaaa taaccaaatc agtcagaact 1802821 tcttttacga tgacattttg aagtgtatct ccgttgatca aattgacttt tgaaaccggt 1802881 acgcccagct cttttgcaaa aacaagctgg cgtctgaggt cagatggatt tccttcagaa 1802941 gacgattgac gtatcagcag aatcagcaaa agcaaaataa aatgcagatc atcttggttt 1803001 tcttctcgat ccacttgttt ctctaaatcc aaatcatccc tctcccttat ccttatctct 1803061 gtttcacaat atgtgcgact tcgatttatg gtataggcta tgtccactcc attaaaaaat 1803121 cagcattttc cttaaataga tgaaaaatag atcaggtacg gcgttcgact cataccaaat 1803181 aacagccgga agaatatgaa taacgtgagt tcactatcga ataggaggtg tgtgtaatga 1803241 gctctgaaaa tgcacagtta aaaaaggatt taattaaagc cgttttaagc cctttatttc 1803301 caactgcaac agaaggagga gaaaatatgg atagtaatct taaagccttg cttgatgctg 1803361 ccatcgatca aaaagtagat gaaagtgaaa cggttacggc agaatctatt ttagaccctt 1803421 ctcttccggc aagatggatt tttgccagaa ttacgccagg cactacaatc agcattgtga 1803481 ctgattcagg tgacatgatc ggaccggttg ttttcgttgc tttcgatcag gttcacggga 1803541 tcgtatttgt aacacaggaa agctccgtca ctccggcagg ccaagctaca acattaattg 1803601 atgtagacaa agtagaaagc gttacgttct tttcataaca tccgatgaaa gtcttgtata 1803661 tccagtcggg atacggagga atatacagtt attttgatcg ctgggctgaa gaatgttttc 1803721 agaacactca tacagagtat atgattgcag ataaacctga agcagaatct ttgatgaaga 1803781 tcgaagcgtt tcagccggat ttcacactta tgatggttgg agaccgcgtt cctcacgact 1803841 ggctgacctg gttaaagggt aaggatatcc ccgtgtatgt ttggctgacc gaagacccat 1803901 tttatatgga tatcagcctt caggtaatta agcttgctga cgccatatta acgatagaac 1803961 aaaatgcagc tctctactat caagagctcg gctaccagaa cgtctattat gttccgatac 1804021 cagttaacca tcggctgttt aaaaaaatgg gcaccgaaca ttcctatcat tcaaatctgt 1804081 taatcatcgg ctatccttac cctaatcggg ttcagcttat gaaagaagcg gtccatctgc 1804141 cattcacggt tcgggtaatc ggcaaggaat ggggaaaata tctgcctaaa aaagtgctca 1804201 aacagccgca tattgatgtc gtcagcacat gggttccacc cgaacaggcc gttcattatt 1804261 ataatggggc agacatcgta attaatgcgc atcgtcccta tcattttgct ttcaaccaaa 1804321 atactatgcg catcaaaaat gccagtttta ataaccgaac gtttgatatc gctgcatgcg 1804381 aagcatttca attaacagat ttacccgcgg cgcatccttt ttcatccatt atttcttatc 1804441 acggcatgaa cgactttaag gaaaaagccg ctttctatat caaccaccct gaagaacggc 1804501 aaaaagctgc agcagccaat tataaagaga ccgtacccgc atttacgttt gatgagcttc 1804561 ctgcaaaact aaaagcgatt catctggcgc tttcttgaaa aatcgttcat tgctatgaac 1804621 gattttttta ttcatagaaa aaagcagctg cacaagctgc tttctattct agccgtcaga 1804681 acggtctttc agcttcctcg gatttacctg tttatgaaga tcaggcattt cgccgagatg 1804741 ctgtgcaatt tgttcccacg atacaatttt gaaattttga ttgacggctt gtccgttatc 1804801 aatattttcg ccgtcctgcg ccacaaaaat cccgtacgga tattttgggc caagtccgaa 1804861 accgagaaca tcaataccat ccgtgtcact agtaccgtct atcttctcgc catctgtaat 1804921 ctcaaagttg gctacatagc gatttttccc ctgccgttca tacattgcat agctgttatt 1804981 tccttgactt gaagccatga gatatccttt gccatttggt gcataataga ttgtcagtcc 1805041 ttcaatatca gctgtcaaat gatctcctgt cgcacggtca acaacctgcc cctttgaccc 1805101 tccgccgggc tcagcgttaa atttccagat ggcctcatct tcctctgcta tgtataggtt 1805161 tccgtactca tcatccgcaa caaggccttc ggtctgagaa ttcaacttaa attcacgcac 1805221 ctttttccct gttacataac cctttccacc atcaacaatt tcatactgct caaattcccc 1805281 ttgtttgcct gtcactaatg cgtaaaatgc tcctgttttc tggctgtgat acaagctgaa 1805341 tccataaacc tcagaaatat tggtggaaat aggatggttc ggatctgtaa tgcttttcaa 1805401 ttttccttta tccccgtcta ttgcatatac ttcaattgta ttttttcctt cggaccggtt 1805461 ggatgcggca gcaatatcaa ttttttcgcc gttcaatgga aaatcatagc gcagatcgac 1805521 attattgagc ttgccaaact cataagaatg aagctgtttt ccgtctaaat catacacaac 1805581 gagccctgac ttcttatttg ttgtaatcaa cttgcttttt tccgggtgtt tttcatgaac 1805641 ccaaatggcc gggtcatctg ctgcatcatc gccagatgcg accggatctg tctccgtgtg 1805701 tgcagtcact ttgaaatgat gttcctcatt cacataatga gccgacaccg aggttgctgt 1805761 caggctaagc aataaacccg cggcagtgct tagcagcatt gtttttggaa ccttcatttg 1805821 gtaccctcct cttttatcac taacactact attgtaaaat atatacaggt gattaccgtg 1805881 aggaaaatga accttttttt atagggtttc tgactcataa acaacttatt ccccaaagag 1805941 gtggtgagat gactttgcca gatttacttt tgcggagcga aataaaaata tgttgaatat 1806001 ttagtacatt atttatttag ttttgttttt ccctagttac gtccgttttt ccattttcta 1806061 ttaaaaaaga acactttgtg acatgatcat tcccctaaat tttgttttat tggttgcttt 1806121 cattaattcg attacaaagt tgaacatatg atgcatggta gagaaacgag agttggagga 1806181 taagccatgc ctaaacagca aacagcagaa ctaaaaccat ttttccataa caaaacagtt 1806241 ttagtcactg gcggaacggg ttcaatcggg agtcaaattg tcaaacgcct tttgatgctt 1806301 acacctaaac aggtgattgt attcagcaaa gacgacagta aacagtatgt catgagccaa 1806361 aagtatgcgg aggataagcg gctattattt gtacttggag atgtacgcga tcacagaagg 1806421 gtgaatcagg tgatgaaagg cgtcgatatc gtctttcacg cggctgcgct gaaacaggtt 1806481 ccgacatgtg aggaccatcc atttgaagcg atccagacca atctcatcgg cggacaaaat 1806541 gtggtggaag ctgccctttc acaccgagtg cagcatgtca ttaatatcag tacagataaa 1806601 gctgtatctc ctgtgaacac aatgggtgcc accaagctgt tatctgaaaa gctgtttcat 1806661 caagcaaacc gccacgtcca aaacaaagga accttgtttt gttcggtccg ctttggaaat 1806721 gttctcggtt ccagaggttc ggtcatcccc atattatttg aacagatgat ggagggtgaa 1806781 cctctgacca tcacagacaa aaacatgacc agatttttca tgtcaataga cgatgcagct 1806841 acattgacat tacaatcggc tgctattaca aaaggcggag aaacctttat tttcaaaatg 1806901 gaatcactga aacttgaaga actgattcat gggtttgaag aatatgcatc gcagcacggg 1806961 ctcccgcggc cggctgcagt agaagtgggc aagcgtccag gtgaaaagct tcacgaagaa 1807021 ttaacatctc cacatgaaat tgaatcactg tatgaatggg gcaaccttta tgcgatcctt 1807081 ccagagccgg aaaaacatcc tgactttcgc aaagtcaatc tgcctgggta tcaatcagat 1807141 caagccccgc tcattacgaa agaaagaatt gctcagatta ttgaagaatt gcatcaagag 1807201 aaaaaggcat aaaaacaagc ctgtctatcc attaggcagg cctgttttta acagtttatt 1807261 tattaaagag atgcagatag ctttcgtatc cttcttcttt tagcttatgc ttcggaacaa 1807321 accgcagcgc tgctgaattt atgcagtaac gaagtccgtt tggccccggt ccgtcattaa 1807381 atacgtggcc aagatgagaa tcagcagttc ggcttcttac ttctgtgcga atcatgccgt 1807441 ggctcgtgtc cagtttttct tccacttctt cttcaatcgg ctttgtaaag cttggccagc 1807501 cgcattggga atcaaattta tctttggatg taaacaatgg cttgcctgac acaatgtcta 1807561 catacaaccc ttcttcctta tgatcccaat attcattttg aaatggcggc tccgtgccgt 1807621 tattttgcgt tacttcatat tgcatgcgat ttaatgactt tattttttct tctttattgt 1807681 acgccattta tttagccccc caatgctcgc tgataaatcc cgctcgtccg gaacctgtcc 1807741 ggtagcgctg ataatgtgct ggattctttt tataaaaatg ctgatggtag ccttccgctt 1807801 catagaaagg ttcagctttt aaaatgtccg ttacaatcgg atctttaaag atgccgcttt 1807861 ccgccagacg ttgcttggaa gcttccgcaa gctccttttg tttatcatta tgataaaaaa 1807921 tggctgcgcg ataggaactg ccgcgatcag caaattgccc tccggcatct gtcggatcga 1807981 tttgctgcca aaataattca agcagttttt cataagggaa tacatcagga tgaaacgtga 1808041 tttgaacggc ttcacgatgt cccgtcgttt cactgcacac ctcttcgtac gtagggtttt 1808101 cagtatggcc gcctgtatac ccggacacca ctttttcaat tcccggctgt tcgtcaaaag 1808161 gtttaaccat acaccaaaaa cagcctcctg caaatgtggc gatttctttt ttttcagaca 1808221 tactggtgcc tcctttgtta atacgtggta ttattatatt atagcatgta aaaatagaat 1808281 gaaaatgatt ctgcttttca ataaaatcta taggttttaa gcaatatgct tatgtaatgg 1808341 aggttcacaa atttgaaagt aagaacacag atgatgtacg atatggaaac tttactccgt 1808401 aaagtcttta aacaaatacg caatgaaatc aatgaaattt tagataaaga gctgtcgcgg 1808461 aatgaattca ccattcttcg aatccttagt gaacaagggc ctaaaaaagt cactgaattt 1808521 gcgcctattt tagaggtatc ggcaagccac attacggctg tgaccgatgc gctggtagaa 1808581 aaggaatgga ttacgagaat cagatcgaag gaagacagac gcatcatccg cattcatatc 1808641 actgaagcgg gcgaaaaagt ccttcagcac tttaacgaga aaaaaacgga atatttcttt 1808701 aaacgctttg actgctacac tgatgctgaa cttgccacgt taatcgagct cttcagcaaa 1808761 cttgataaaa aacggtgaaa aaaagcacat accgatatat aggtatgtgc ttttcgcagt 1808821 gcttcactta tttttcagta aacagcttca ttgctttcca gcggccatat ctataataca 1808881 aaaatgccgc gcagctgcta aataaaaaac tcattccgat tccaagcccg attccttttt 1808941 gtccaagcca agctgaaaat agagctgtga aaggatacct caacacccaa aacgagatca 1809001 aatttaatac cagaacctgc agcatcgctc ccgcggccct gacgattccg ttcagcacaa 1809061 aattaacccc aataaaaggg tagaaaaacg cgatccactt caaatattgt tcaccaaatg 1809121 cgaccgcatc aggctcactg ataaataacc ttatgaggta tttaccaaat acccaaatca 1809181 taaccgcaat caccagcatg caggaaataa cagctatcac acctagcctt gcaattgttc 1809241 ccactctttt ttcgtttccg attccaatat tttgccctgc catactattg acggccgtac 1809301 cggcagccat tgctggaagc gtgatgatgc tatcaagccg ctgcaccgcg ccaaagcctg 1809361 ataccacgtg atccccgtat gagttaacaa cactcataat cgccatcata ccgcctgtaa 1809421 tcaccatcat ctgcagacct gccggaatcc cgagtttcaa aatcagcgcg gactcttccc 1809481 acttgggcat tctcggaatc gagaatggca caagcttgtg tttgatgaca taaaacaacc 1809541 catacaaaaa cgcaatgccc tgtgacaaaa tcgttgaata agccgctccc gctattccca 1809601 tgcggaacac agaaataaag agcggcgcaa gcactgtatt cagtacaaca gcaaacgcaa 1809661 taaaccggag aggtgtcttg ctgtcgccca gcgcacgaag cacagtactg ataaagttat 1809721 aaccaaacaa aaataaaatg ccgataaatt gaatctgtaa atacgtctca gcaagcggta 1809781 tcattgactc cggcgttttt agaagacgca gcaaaagctc tgagagaaaa aaaccggccg 1809841 cgccgaatcc gatgcttagg cctgttaata aaacaacaaa agcgttaata tacgacgcca 1809901 ttccttttat atcatctttt cctttttgct gagataaaat ggttaacgtc gcattgttaa 1809961 ggcccaaaat aaaagacagc acggtcaaaa caatcgtgct tgataccgcg gctgccccaa 1810021 gggcctttgc ccccagtaaa ttgccgatcc acaagctgtc tataaattga aaggaaacct 1810081 gcaatgcgtt tccgagcata ataggcattg aaaacagtac aagctgtttc agcacgttcc 1810141 cctgtgtaaa atcgtatgct ttcatctttt ctccttgtgt tctcaaattt tcttcggacc 1810201 acacgaaaaa agagacgttg tttcatgtct cttttttcat gacttatcgg ttttttttcg 1810261 gtctcgcata ccgaatgtaa acaccatcac acttaggaac aaggcacaat aggaaacatt 1810321 caaatacatt tgatccatat cttcagcagc cagatgatga taagcaagcc agccgaagta 1810381 cagggaaaat gtaaaggata ataaactgaa atactggtaa atccgtttca ttttcagtca 1810441 cctctattgt ttaggatggt aataggaaaa ctcaatttca tctttttcta aatttatctt 1810501 atccgctttg acatacattc cattcgttaa aggcatttct gacaaacgca cttcaatgct 1810561 tttatctccg gggtgaacat ggacaaatga cggcaattca taaaagctgt ccatataatt 1810621 taacacaaag ctaattggta tactcaattt ccctaacgaa aatttcgtga cattcagctc 1810681 tacatcaccg ttttttttca cggtcggctc aaaagcgata aacgcatcaa tagacgtgga 1810741 aaatgccttg attttccctg cgacatgaac atcatcatca atctctactt tataatcaag 1810801 cttgtttgat gctttgtcgt ttaaatatga gttaacaaac gcagctaatg attcttttgt 1810861 gcttgtcact tgaaatccat actcgctctc agatgcatct ttcacctgag cctgttcccc 1810921 cggaagcaaa acaagtgcca caaacccggc ggcgaggata aaattgattg caagcaatat 1810981 aaaaaacagt cgcttccact tattcatgct gtcaccctac tctttcggta atccttcttt 1811041 tttaatggct tgatagacgc gctttgcgat aagagaataa cccgtaccat taggatgaaa 1811101 atcatcttcc tcagaaattc ggctgctgtc acttttttga ttaaacaaat cttcgatatg 1811161 gacgattttt gcatgtttat cttttttcag ctctttttca gcaatatggt tccaatccgt 1811221 gacgacacca tttatttcat ttagttctga taatgtaaac gtaaacggat tgtacatgct 1811281 gacataaatc agctcagcgt gatcattcag ctcgcgaatt tcagaaatga ttttttcaaa 1811341 gcgcttttcg tacggttttt ccgcttcctg aaacggttca acggttaatt gcagaaagtt 1811401 ttggcgaagg attttcatca aatcattacc gccaattgta aaaaagacat aatctgcgtc 1811461 ctttatgcct ttttgaacct ttttatcttt tagtttttct aataaatcat ccgaacggtt 1811521 cccttttaca gcataatttt tcacgtcgac cgttttgact tgtttatctg accggataga 1811581 atccgccacc ttgccgacat atccctttcc gtcgggatct ccgactcctt ctgtcagcga 1811641 atctccgaca gccgctatga caatgtgttc ttttgttttc gtttcatggg ctttttgttt 1811701 tccctcagat gatgtacgta tgctcgtaca cgcagtaaga agcaaaatca aactggccat 1811761 gattgaaaaa atgcgcagct tcaatcttgt tgctccttcc cattctacta gtggaaagtg 1811821 tatcatgttt tagaagattt gcaaatgcct agtctcttag cttacttgag tgtactggct 1811881 gacttcacat cggaaatgat atcatcgtac ggtgtattct ccactccatt gtaatctttc 1811941 agcaccttac cgtccggacc taccaaataa aaagaagatt gatgaatcac ttggtcctct 1812001 ccctccggct tctttacgat cgctttaaag ctcttaagtg cgaactcctc aatctcactc 1812061 tggctgtatc ccgtgagaaa atcccagtta tcaaaagata atggataatt tgcggcaaat 1812121 ttcttcagct gtttcggctt atcgttttct ggatcaacac taaatgatat gatgcggaca 1812181 tctatatttt cggctttcag ttttttttgc agatcggtca tatgagcggt cattggcgga 1812241 catatagttt cacaattggt aaaaataaaa tccgccagcc atacttctcc ttttaaactc 1812301 tctaaagaaa cgttcttgcc gtcttggttt tgaaatgtaa aaggctccac ctcgtaattg 1812361 agcggatctt taatctgctg tcctccgcat gcacacaaaa acagaaaaat cagcccagcc 1812421 gttaacccct tgataacctt catgacatcc atcctttcca gccagcataa aaacgctttc 1812481 taaaaccgtc cttactgtcc catgtttgta ttcgatactg agcaaaaaaa atcctgcatg 1812541 cctccccatt aacgattaca aaggagggca tgcaggtaaa aaacggcatg ttacgcgttg 1812601 tgctttaaca cctcttgatg aaatacagcc tgataatctg cccacttcat ccgccgcttc 1812661 atataatgtc ggaaagaata cacttttgcc ctgctgtttg atgaaaacac ttcttttaag 1812721 tagaattgca aatggtgatg taacataaag aaatagtgct catcttcctt taatacaggt 1812781 atttctgtca ctttcacctg aatcccgtca ccgcgtttga actctaggct tttgagtaac 1812841 aagctatcaa tcctcttttt tgtttttctt ctattatata tgatgccagc cgggctgtct 1812901 gtcattttgc gcggttgtgt aaaaaaatta gattagcaaa tggaacaagt cctcatcctt 1812961 gttcacctct acataatgaa acggtttttt gttcatccgt tcaatcagcg gcccataatc 1813021 ggctttgttc tgcagctcga tgccgacaag agcaggtcca ttgcttttat tatttttctt 1813081 cgtatattca aaccttgtaa tgtcatcatt cggcccgagg acttcgtcaa gaaattcgcg 1813141 gagcgccccc gctctttgtg gaaaattgac gataaaataa tgctgaaggc cttcaaaaat 1813201 caaggaacgc tccttcattt cctgcattct tccgatatcg ttattgcccc cgcttaccac 1813261 acacaccacg tttttccctt taatttgatc cttgtacaaa tcaagcgctg cgacagaaag 1813321 agctccagcc ggttcagcaa caaccgcaca ttcgttatat aattcaagaa tggatgtaca 1813381 tacttttcct tcaggcacaa ggagaatgtc atcaacgaca gtttccagcg tccggaaggt 1813441 ttcctcgcca atttttttaa cagccgcccc atctacaaac ttatcaattt tatcaagtgt 1813501 gacgacatgc ccagctttgt ttgattcaaa gtaggatgcc gctcccgccg gctcaacagc 1813561 aattaccttt gtatcaggag acacgttttt caaatatgta cctaccccag agagaaggcc 1813621 gccgcctccg acacttgcaa aaagaaaatg cggttctgta tcaatgtcgt ttaaaatctc 1813681 gactgcgagc gttccctgtc cggccatcac atccggatca tcgaacggat ggataaacgt 1813741 ccgagattcc gcctcacagc attcagcagc gcttttatac gcgtcgtcaa acgtatcgcc 1813801 tgtcaaaata atatcgataa atccttttcc gaatagttca acttgagata ctttttgtct 1813861 cggtgtagta gacggcataa aaattttccc gtgaatgcca agatgtttac acgaaaatgc 1813921 cacaccttga gcgtggtttc cggcacttgc acacacaact ccgttctctg tctgctcgct 1813981 ggaaagctgt ttcattttat gataagcccc tctgagctta aaagatctga caacttgcaa 1814041 gtcttcgcgt tttaaataga tattgcattc atatctctca gaaagtctgt cattcctctg 1814101 caaaggtgtg tgaatgacaa cgtcctttac gttttggtga gccttcaaaa tgtctttcac 1814161 ttggatgaga gagttttctt taagcaacgg tttcatgtac agattccttt cttgttttaa 1814221 atccctattt aatatgccat tataacatga atattcaaaa aataagacaa ttatttttat 1814281 ttaataatta aaaaaataca gactatgtcc accacatctt gtggtaactt ctgttcaacc 1814341 attatcctgc agagccaaga aaaaagatga tcgtaaaata aagggtgttt tcaaccaaaa 1814401 ggcatgatat aatgaaacca attagaacca aaaggagcca attgatgaat agtgcaccaa 1814461 aactcaatac atttcaacat ctaatcggag aacatcaaac ttttctggaa gcgaagcgaa 1814521 tcgccaagca gttctcgtta tcggagcttc ctgtcttaat aacaggaaaa atcggaacag 1814581 gcaaaaatca cttcgcacat gccatacact tggaatcttc gagaagcaat gaaccgttta 1814641 taagcgtcaa ttgcagcacc cattcggaag aaacccttat tcatgagctt tttggcccta 1814701 acggaaacac aggtgttttt caaaaagcgg tacgaggaac cctttttctt gatgatgtat 1814761 ggcgcatgcc tgcttctgta caagctcagc tgttaaaagc gcttgattca gacacggaga 1814821 aaccgcgaat gatctgtgct tctgcagacc gatccgtgga acatacattc aggcaagact 1814881 tattctacag actgaacatt ttaacgctca cactgcccga attatcggaa cgaaaaagcg 1814941 atattccgct tttgacacag cattttctct caaattctgg tcagcaattg ttaatcgatc 1815001 cctccgtttt tcccgtgctt gagaagcatg catttgaagg caatgtcagg gaattaaaaa 1815061 acgctgcaga ttatatggcg gcagtatcaa gcgggggaac gattcagcca tatgacctgc 1815121 cgccgtatat tagaggcacg atagacggaa aaacgtcgaa gaaaaaagcg aaactgctta 1815181 ctttaatgga aaaagctgag tttttgttta ttttggaaac aataaaagta ttgaacgaaa 1815241 aaggagaacc tgccagcaga cggatcattt ctgaacacag caaaaatacc caaacctcgt 1815301 taactcctca gcaggtcaga agccgtctcg actatttgga gaaaaaagat tatgtcacca 1815361 aaagccgcgg acgcgcaggc acaaaaatta cctttgaggg cttgagcttt atagagacgt 1815421 taaaaaatca aatgatctag cgatcgaaag gagaatgtac ttgtttacaa tcaaagaaga 1815481 gatcgccaat gcgattacac acggcatcgg tgtcctctta tccatcccag cattagtgtt 1815541 tctaatcata tttgcggcta attacgggtc tgcatgggac attgtcagct ttacaatatt 1815601 cggtgtctct atgctgctgt tatatttgag ctccaccctg cttcacagca tcacacataa 1815661 aaaaacgaag gacattttgg agattattga tcatagcgca atttacgtac tcatcgccgg 1815721 aacctacacg ccttttttgc ttgggccgct gaaaggcaca ctcggcttta ccctgttggt 1815781 tatcgtatgg tcacttgccc taggcggaat cgtttttaaa attttctttg tgaaacggtt 1815841 tatcctattg tcaaccttcg tgtatttagt catggggtgg ctgatgatta ttgcagttaa 1815901 acctttatat gcttcactga gcggagcggg attcagcctc ctttttctcg gcggcatttt 1815961 atactctgtc ggaaccatct tttacatttg gaaaaagatc cccttccatc acgccatttg 1816021 gcacagcttt gtattgggcg ggagcgctgc catgtttttc tgcgtgctct tctattgtgt 1816081 aaaggtgcct ttcctttcgt aacagtaaca gaaaagcgca gtcttcacga ctgcgctttt 1816141 ttatgcacgt aattgttttt cattggcagg tatataagct tttgaaaagg acaattcaat 1816201 gtctgccggt tttaagcgtt taaaaaacga gccattttgc atgttatctg ttcctttcgt 1816261 ttccaccatc accaacggaa gatgatagcg ggccgcaagt tctacaggat caatagaacc 1816321 atctagtgaa agaatcaggc tttgtccctt ttccagctgt tttgtcacat cttcatatac 1816381 cttttctgaa tccccgtctg aaatcacatc catccgatcc agccattgcc cgataaaagg 1816441 caagcggaac acttttgggt tagcgataaa gccggccggt tcctcaatat atccagcaat 1816501 taaggccagt tcagccaaac gcaaacgggg atgcacatac aaaacaggac cgtgtggtat 1816561 tggctctggc tgatggatcg tcacaactga accggagatg ccgatacagc cttctaaaaa 1816621 cgcctttggc tgttcgtaca caagagccat ctgttttttg tatgacagac ggggatcgag 1816681 cattgtttga ttaaataatt gtttcatatt ttttaacagc atatacacaa tataaaccac 1816741 tagaaggctg tagcgaacca attaaaatcc tcccgcttta gaagaattct ttttttcata 1816801 cattagaaat tcgtaatcat acgggttttt ttcgtctttg gtcccctgct cagaagaaac 1816861 cagcttccaa ttggattcat caaattcagg aaagtgacgg tcaccctcaa actcgtgatg 1816921 aattttcgtc atatacagtc tgtccgcata agggaacagg tccgtataga gctgagcccc 1816981 tccgatcaca aagcattctt cagggcctga acaaatgtcc agtacatcct ttaatgaact 1817041 gacaaccgtg catccctgaa attctgaatc cggcgctgag gtaacgacaa tatttttccg 1817101 atttggaagc ggacgtccga tcgattcaaa tgttttccgg cccataatga ttgaatggcc 1817161 cgatgttatt ttcttaaagt atgcaagatc attgggcaaa tgccacggca aatcattgtc 1817221 tttgccgata agcctgttgg catccatcgc aaaaatgaat gaaatcatac gctgaccgcc 1817281 ccttttatat gaggatgcgg atcataatcc tcgatgataa agtcctcaaa tgcaaagtta 1817341 aaaatagaat caacctttct ggcgaaacga agctgcggaa gcggtctaac atctctttcc 1817401 agctgcaaat tgacttgttc aatatgattt tggtaaatat gaacatcacc aaacgtatgg 1817461 atgaactcgc ccggttcaag cccagtcaca tgagcaatga tcatggttag gagggcataa 1817521 gatgcaatat taaacggcac acctaagaaa acatcggcag agcgctgata cagctgacag 1817581 gacagcttgc cgtcagacac atagaattgg aacaggcaat ggcacggcgg caacgccatt 1817641 ttatcaattt caccaacatt ccaggcgctg acgattaagc gtctggagtt cggatttgtt 1817701 ttaatatctt caataagacg ggaaatttga tcaatggttt ctccatcagc tccccgccaa 1817761 gaacgccatt gggagccata tacaggtcca agttcaccgt tttcatcagc ccactcattc 1817821 cagattcgca ctccgttttc ctgcagatag cgtacattcg tatctccttt taagaaccac 1817881 agcagttcat gcgcaattga tttaaagtgg agttttttag tggtgagcat cggaaagcct 1817941 tcccgtaaat taaatctcat ttgatatccg aaagtgctga ttgttccggt cccagtccgg 1818001 tctccctttt tctcaccatg ctctaaaaca tgtctgcaga aatccttata ctgtttcatt 1818061 tttttcatcc tttaaaagta gtcttctagt agtgtaacac aataaaaaat catttctgaa 1818121 cccagaaatg atttttttat agtcagctga cgacaggctt ttcatcctgt tctttttctt 1818181 catcttgcag atcctgatgc gtatgtgcaa ttctgctcgc cgctgctgca gcaagagctg 1818241 ccacaatatc atccaaaaag gtgtgaatac cgtctggact ttcatcaagt tccttaataa 1818301 ttccaatctt ctctttatcc aaataaccga aattggtcaa accgatcgac ccgtacacat 1818361 taacgattga aagcgggata atttcatcta tgccgtaaag cggttcatcc gtttcaacaa 1818421 ggtgctgcag cggttcgggg agaagtttct gttctgcaag ctgatcgagt gcaaggcctg 1818481 tcaaaacagc atgaataatt tcacgtttgt tcaggacttt ttctacattc tccatgcaaa 1818541 cactgagcgg cagatttgga ttgtattttt cctgaagttt ttgaacaatc cgtgcaatat 1818601 cttctatcat aacgccccgt ttgttcagca tatcctttgt tatatcgacc atttcattca 1818661 ttgtgtactt tttcatgtct aatggcatct cctttaggca ctcatccagt tgggaggcgt 1818721 gttgcggtcc cagtaaatgc tcccaagctc atgatgtgat tgaaatccat cttctgctgt 1818781 atgataatga aaattaaacc agtagccgtc atgaggcggg tggtctcttc gcacatggaa 1818841 tctgagaaga tcttctccag ttgtccgatt gtaaacgttg aaaatttttt ccgttttgcc 1818901 cgctgaaggc atgcttgaga tcacaacatc ttggtacgcc tcatcatctt gcaatgtcgc 1818961 taaataatca ctaatcacat tttcgatttt tggcaggatc tctttccgat agtcatcctc 1819021 aatgacagga gcgattctgc tgccgaattt taaaaaggac tgatcctcag cgctgtcaag 1819081 gagctgttcc ttgtacgatt gaaaaagcag ttcaggatct cgcctgtcat ccgactcatc 1819141 atcgtacagg tcatgctcat cataaaaagc ggtgtaatca ttctgctcaa gactgctcgg 1819201 ctgtccggaa ggcttgtccg ccataagggc agccggagga gatacgagcc cgaacgttac 1819261 aatggtaaat aaaaccacaa gggtctttct catccacaat ttcatgactg cttattcctc 1819321 tctattttat tgtcatgttt ctcttatttt agcacatcca aaacatgcaa gtcatgtact 1819381 atatgaaact gatatgcaaa ttaggagatt cgttgctatg cactttgtgt aaaaacgctt 1819441 acaatatttc atgaaaggag gctttccgca tgattgacgc tctgtttgcc acagtttcac 1819501 tcttaacatt attatacttt gtcgtcatgg aggtcaccga ttaacagaaa gcccgtgata 1819561 tgaatcacgg gcttgtttga atgacgccat aatggaacag tgctgttttt cttttcatga 1819621 cgttaaaacc aaactgttca aaccgcgggc ttttccagtg gtcttttagc acaacgcttt 1819681 ttctggcgac tcgtaccgct tcattgatac atccttcgtg caaaacggaa tcctctgcca 1819741 aatcacgtaa aggcgcgatg ccgtcagagg tttctacagg ttcatgaaac attggatcga 1819801 aataaaccac atcaacagag ttgtcaggga gctgcttgat gtgttcaaag caatcaccat 1819861 tcttcacctg gattcttctc atcgcagctt gaagctcttc tatacccgtt tcccatgaat 1819921 gcagccccgt cctcactaaa acagacacaa gatggttttt ttcaatccca acaacagaac 1819981 ccgtttcgcc tactgccata cttgcgataa tggcatctga ccccaacccg agtgtgcaat 1820041 ctaaaaacgt atccccttca gataagccgg cagcccgaag cataggttct ttctccccct 1820101 gtaagaagcg tttggctctg aacatcgctg tattcggatg aaaaaagaat ttggcacctt 1820161 gtttcgtata cagctcaaac cgctctttgc cgaccacaag caaatcacgt tcagctgatt 1820221 tcagcaggtg ctcaaccgtt tgtttattcc ggccgcagta tggcatattt agctctttag 1820281 aaagctgctt tgcagttttt atggtgtgtt cagacggtct atagcttgtt gttatcatct 1820341 tctgtactcc caaaaagaaa atgcccggag aacgggcatt tagcagtgcg catcgaaggc 1820401 agcagtcaga tttttcatga tttcttccat atcgtgtcct tcaatttcat gacgcggaat 1820461 aaaatgtacg acttctttgc ctttcaaaag agccattgat ggtgaagaag gctcctggcc 1820521 agtaaaatac tcacgcattt tcgcagtagc ttctttatct tggcccgcaa atacagtcac 1820581 cgtattgtca ggtgttttgt cattctggag gactgcctgt gtagccgcag gacgcgcaag 1820641 gcctgccgcg cagccgcata cagagttaac gactacaaga gttgtgccct ctgccttttc 1820701 cataaagttt tctacttctt ccgctgttgt taactcttca aaacctgctc cagtcagctc 1820761 gcggcgcatc ggtacgacaa gctggcgcat gtattcttca taagccattg acataaaaaa 1820821 agccccctct agtatccttc atctgaagta aaggatacta tagagagggc cggatttcaa 1820881 atgttcacgc cttaaaataa aagaaagtgt ccccagctat ctagattttc ataataccgc 1820941 cggtgttggc acttgtcaca agtttagaat aacgtgccag gtagccggtt ttcactttcg 1821001 gttcaaaacc tttccagttc gcttttcgtt tttcccactc ttcttctggc acttgtacat 1821061 ccaagatgcg tttttcaata tcaacgataa tatggtctcc gttttcaaca aaggcaagcg 1821121 gcccgccctc agcggcctca ggtgatacgt ggccgattga gaggccacgg gaggctccgg 1821181 aaaaacgtcc gtccgtaatc aatgccactt ttggcccgag tcccattcca acgatttggg 1821241 atgttggcgc cagcatttcc ggcatgccag gtccgccttt tggcccttcg tatctgatga 1821301 tgacaacgtc gccttctttt acttttcggt tgataatgcc gtcaagcgcc tcgtcctgag 1821361 aatcgaatac gacagccggc ccttcgtgtc ttgtaatccc attctgtacg ccgcctgttt 1821421 taatgatagc gccgtccgga gctagattac cgaataaaac agcaaggcct cccttttcag 1821481 tgaatggttg atccagcggg tgaatgacgt cataatcctt tacttcatgt ccggcaatgg 1821541 tttctccaag agtttttcct gtaacagtca gcgcatctaa atgaagcgct ccttctttct 1821601 tcgaaagctc attcagagcc gctgaaacgc cgcccgcttc gtgaagatct tcaataaaca 1821661 catccgatgc aggcgccagc ttagccaagt gcggcacgcg ctcagcgact tcgttaatgc 1821721 gttctaaaga gtattcaacg ccggcttcgt ttgcaagggc aagggtatga agaacggtat 1821781 ttgtagaacc tccgagcgcc atatcgagtg caaacgcgtt atcaatcgct tttactgtaa 1821841 caatatcacg cggtttgata tctttgcgaa tcgtttccat taattgcgca gccgattttc 1821901 tcacaaactc tttgcgttcc ggagatgttg ccagaatggt tccattaccc ggcaaagcaa 1821961 gaccaagtgc ttctgacaga cagttcattg agttcgccgt aaacatgcct gagcaagacc 1822021 cgcacgttgg gcatccgaac tgctctagtt cttgaagctc gttttcgttg attttccctg 1822081 cttggtaggc gcctacccct tcgaatactg aggaaaggga gatttttcgc ccgtcacttg 1822141 ttcttcctgc cgccatcggt ccgccgctga caaaaatcgt cggaatgttg atgcgcattg 1822201 ccgccataag cattcccggt gtgattttgt cgcagttcgg aatacagacc attccgtcaa 1822261 accagtgtgc ggatacaacc gtttccacag agtctgcgat aatttcacgg cttggcagcg 1822321 aatatctcat accgatatgc cccattgcga tgccatcatc taccccaatg gtattaaatt 1822381 caaacggaac gccccctgct tctctgattg cttcttttac gattttccca aactcctgca 1822441 agtgaacatg accgggaacg atatcaatgt atgaattaca caccgcaata aacggcttgc 1822501 cgaaatcctc ttcttttacc cctgctgcac gaagcaaact gcggtgcgga gctctatcga 1822561 ttccttgtgt gatcatatta ctgcgtaatt ctgccatggt gatcctccta aattctttca 1822621 attgtttgat tggattttat tttgacaatt ttcagtttat ttatgggctg tttttgcaaa 1822681 taagataaat acaggccgcc ctcaccttgt tttgttcttt cgtgttttta tatttatata 1822741 gctttctttc gatttgaacc ctccaactat taatattgtt acttactata aatagttttc 1822801 ggatattttt caacaatatt cgaaataatt tttataaaaa gtgaattcac ataaaaaagg 1822861 tgcatgatct gcaccttttt tatctttatt cgcctttttt tctgctttcc gtcatttgtt 1822921 tccaaacaga accttttgct tcttctccat gctcaatacg ttcaagcgcc attttgactt 1822981 gaaggctgac ctcaaattcg gggtcatctt cggcagcgcg caaagcttca attgcacttt 1823041 catcgccgac ttcgtacagg aacatggcgg cacgccagcg aacaagcttg ctggagtcgc 1823101 ttaatgactt gatcatagca ggaatggctt gaggatcgcc gatatcagac aggcagtctc 1823161 cggccgttct tctgactgat acagctttgt cctcaagtgc tttatacaat agaggaagaa 1823221 catcaggtgt ttcaatcatt cctaagtaca caacagcctg tcttctgatg gacacctttg 1823281 gatcatccaa tgccttctgt aaaaccggga tatcctcttc tttcggatcc atctgttcca 1823341 agtgtgcata acgctttttc cagtcctcat catccagcat atcaagcgtt actttatacg 1823401 ctttgcgctg tacagcttgt tttgcttcgc cctttccttg agcggctgct tcagtcagtc 1823461 gtttcagccg ttcatcactg tatgccgctt gaagctcttc tgtcacatca tggccgattt 1823521 catcaaagtc accgaatctg acaccttgtt ctttccaagc ccgctcaaac acaacattgg 1823581 aagcttcaga tctaagtttt aagatcgcct gctgaaagcg ttcaggtaag ccgaagcgtt 1823641 cttcccgctc tccatcggtt aatttaactt gcataggaat gccgctgaac atctgcacaa 1823701 aaacttttac ctctccaaaa gattcttgat cagaacgatt ttcttctgcg ctttcagcac 1823761 tttccatccc aaatgcagtg cggacttgcg gtaaaatgtc tttccagtcg tatcttgcat 1823821 tccgttcaac agcaagaaaa tctgcgacgt gatatacccc tttaactcca tctattttaa 1823881 ggatttccgc tataacaagc ggtgcgcctt ctgcttgctc aggtttatag ttattgcttt 1823941 tgcccgccgg aagctcttcc gttaagatga ctttcattgt attcgggctt ggtgtaggtt 1824001 caattgattt tatcttcatg atcgtcctcc tatagcatat ctgtgactta ttctatcata 1824061 gtcgctccaa gccttctatt acgacgtttc ggcatcaatc ccgggtatgt ctttttctaa 1824121 ttggcggaca aattgaagca taaaattgtg tctttcttct gccagttccc gtgcagtgtc 1824181 tgtattcatc atatctttca gccgcagcag cttatgaaaa aaatgagcgt aggcgctttg 1824241 ctcatctcca taaaggccat gcccttttgc gcccgcaaac atgaaagctc tcgcaatgcc 1824301 gacagcacca atcgcatcaa gtctgtcagc atcctgtaca gcttttcctt caattgagag 1824361 cggctccttc gccaatttcc ccctgtcccg aaaggacatc cttgttataa tatgaatcac 1824421 cctgtcagca ttctcttttc ctactccgaa aaaaacgagc tgatcatata cttcgctcac 1824481 agaaagcctg accgtgtcag gcagcttcac atcaattaaa tcatgaacca aagccgccgt 1824541 ttcaacaatg aacaaatccg ctttttcctt ttctccaata tacgctgcaa gatctgctac 1824601 tcttgataca tgatgccagt catgtccaga gctttcgtca gtcaggatag attgaaccca 1824661 tgtcctgatt tgctctgcct gcttcaattc cttcacaaaa acaccctctt tttattgctc 1824721 taatagcttc acgatatcgt cttccaactc tttcggattt gtatttggtg aataacggcc 1824781 aacgatttct ccatttctat ccactataaa tttcgtgaaa ttccacttga tcgccttagt 1824841 tcccagcatc cctttcgcat gttctgtcaa atacacaaac agcgggtggg cgtttttccc 1824901 gtttacatcc acttttgaaa acataggaaa tgtaacaccg taatttgttt cacaaaattc 1824961 ctgtatgtca gcctcttcac caggctcttg gttcatgaat tgattgcagg ggaaccctaa 1825021 gatctccagc ccctcctgct gatatgtatc atataattcc tgcagctgct tcaattggga 1825081 agtaaaaccg cacttacttg ctgtattcac gatcatcagt acctttcccg cgaaaggctg 1825141 aagtgtcatg tctttccctg tgattgtacg taccttcata tgataaatag acatgtaagt 1825201 ccctcctatg tccttggtgc tgattatttt acctttttta aatcgcaatt caaaatgtaa 1825261 acatcaatta agaactcata agaaacctaa cgatatgagc gtcagttcat tatcaattca 1825321 tatggctcgt tttttatctt atcattctat aaaacattac aattccctct tacatctttg 1825381 aaaatcattt tactgtgaaa ccaaaaggcg tgtcagtgcg ttttatttaa agagttttct 1825441 gttgtttccc cctcaacacg tatagataga ttgaaaattg gcgtgaaaat tcctataatg 1825501 aagaaaatta aacggggaaa taatggaggt ggcacgttgc ctattaatat accaacacac 1825561 ctgccggcaa aacaggtgct tgaaagtgaa catatatttg taatggatga aagcagagca 1825621 tttcatcagg atatccggcc gcaaaaaatt attatattaa atttgatgcc gaaaaaaatc 1825681 caaacagaga ctcagcttct cagattgctt ggaaattcgc ctttacaggt tcatttcaca 1825741 tttttaatcc caagcacaca cacgccgaaa aatactgcga gagaacacct tgacgaattt 1825801 tacacgactt tttccaatat ccgtcacaag aggtttgacg gcatgattat caccggtgcg 1825861 ccgatcgagc atttggcgtt tgaagaggtt tcatattggg aagagctcaa ggaaatcatg 1825921 gagtggagca aaacaaatgt cacttcaacc ttgcatattt gctggggtgc tcaagcaggt 1825981 ttgtattacc attacggtgt ggaaaaaatt caaatgccga aaaaaatctt cggtgtgttc 1826041 gaacataccg ttctttcaaa acacgaaaga ttggtaagag gttttgacga gctatactac 1826101 gtgccgcatt cccggcatac agatataaat atggaacagc ttcaagcagt gcccgagtta 1826161 aacattctta ccgcatcaaa ggaagccggg gtttgcttaa ttgtgtctaa agacgaaaaa 1826221 caagtctttt tgacagggca ccctgaatat gatacaaata cgcttcttca agagtatgaa 1826281 agagatttgg aacgaaacct ttctactgtc gaggccccta aacattattt tgcaaaaggc 1826341 agcaacgagc cagtgaatcg ctggaaagcg catgccacat tattgtttat gaattggctg 1826401 aattattacg tttaccaaga aactccttat gaatgggact aatttttctt tttttagtga 1826461 tacgctgagc aaaaaatatg ataaaataca tctgattcag tctgcgtata acaaaaattt 1826521 aaaatactgg aatccaaatc atttaaaatt agcttaactt tttcactgca ttaataattc 1826581 gattatgtat ttgtgttatg tttatgtata gacaataact ccttacgatg catgaagctt 1826641 gcttgttgtt gattacattg aggtgaattt acttgaatac caataaaaga gtattaattt 1826701 tgactgcaaa ttacggaaat ggacatgtgc aggtagccaa aacactttat gaacaatgtg 1826761 tacggctcgg ctttcagcat gtaacagttt ctaatttgta ccaagagtca aatccgattg 1826821 tttcagaggt aactcaatac ctttatttaa aaagcttctc aatcgggaaa cagttttatc 1826881 gtttgtttta ttacggagtt gacaaaatct ataataaacg taaattcaat atttacttta 1826941 aaatgggtaa taaaagattg ggcgaacttg tcgatgaaca tcagcccgat attattatta 1827001 atacatttcc gatgatcgtc gtgccggaat acagacgccg aactggaaga gtcattccta 1827061 ccttcaacgt tatgactgat ttttgtcttc ataaaatttg ggttcacgaa aacgtggata 1827121 aatattatgt ggcgacagat tacgtgaagg aaaaactgct ggagatcggc actcatccaa 1827181 gcaatgtaaa aatcacagga attccaatca ggccgcaatt tgaagaatcc atgcctgttg 1827241 gcccgatata taaaaagtac aatctttcac caaacaaaaa agtgcttctg atcatggcag 1827301 gtgctcacgg tgtattaaag aacgtaaaag agctgtgcga aaaccttgtc aaggatgacc 1827361 aagtgcaagt agttgtcgtg tgcgggaaaa atacggcttt aaaagaatct ttgagtgcgc 1827421 ttgaagcgga aaatggtgac aaattaaaag ttctgggcta tgtggagcgc attgatgagc 1827481 tatttcggat cacagattgc atgattacca agcccggcgg cattactttg acagaagcca 1827541 cagccattgg agtgcctgtc attctgtaca aacccgtgcc tggccaggaa aaagaaaatg 1827601 caaacttctt tgaagaccgc ggagctgcca tcgttgtgaa ccgtcatgaa gagattctcg 1827661 agtcagtcac ttcccttctt gcagatgaag ataccttgca tcgcatgaag aaaaacatta 1827721 aggaccttca tttagcaaac tcctctgaag tgattttaga ggatatcctg aaggaatcag 1827781 aaatgatgac cgccaaacaa aaagccaaag tgctatcgta atggcgtact tgagagcata 1827841 cgaaaatcgt gtgctctttt tatttatatt cagccatcaa taaaagcggt tacatttttt 1827901 tatggaactt gcccttcttt tgaaaaataa gccgtttcgc aacttgacgg gtgctcccag 1827961 atggtgtata gttgaaccat catttaacaa tgaatcaaag ttagatgatg acaaaatttt 1828021 ttttagcaca tgggtgctac agtactagga ggaattaagc aatatgcaaa acggtaaagt 1828081 aaaatggttc aacaacgaaa aaggattcgg cttcattgaa gttgaaggcg gagacgatgt 1828141 atttgttcac ttcacagcta tcgaaggaga tggatacaaa tcattagaag aaggacaaga 1828201 agtttctttt gaaattgtcg aaggtaatcg tggacctcaa gcttctaatg ttgtaaaact 1828261 ctaaactcaa tacatgatga tgagatgaca aatagaggag aggcattcgc ctctcctatt 1828321 tgattttcat ctggatttca atcgccaaaa tgttttgttt acacctctgt tcaatctctt 1828381 caacatactt ttccattgat ggttttcctt ttttcgcgat atcggccagt tcttctaaat 1828441 cactgtatat ttctataaat gttttgtgaa ggatcaactt caagtcttta tcatccatag 1828501 ctgcgttccc cttctctatc aagatacctc aaatagtaaa acggtcctat ttattctggt 1828561 tcaatagtta tatcggctta tttttatttt cttttctatt ttggtacata aatttcaaaa 1828621 aaactctgca aaataatggc ggaggtgttt tttgtgactt cagaatttca taatgaggat 1828681 cagaccggct ttacggataa gcggcagctg gaactagcgg tggaaacagc gcagaaaaca 1828741 acaggagccg cgacgagagg ccaaagcaaa acattagtcg actctgcata ccaagccatt 1828801 gaggatgcta gagaactgtc acaatctgaa gagctggcag ctctcgatga tcctgaattt 1828861 gtaaagcagc aacagcagct gctagatgac agcgagcatc agctggatga attcaaagaa 1828921 taaaaaccgc agcttctgcg gtttttattt ttagtgattg gttaagacat ctccgtattg 1828981 tttcaacttt tcaccaaccg tacatttatt gatacaaaat gaatgcgcat aagttttgcc 1829041 aaattctttg cgaaactgct tcttaataaa acagtccttg caatattcat cgtgcagttc 1829101 tgtcagttct ttaaagatca ttttcttatc caatatcgtc atctccgtta cggtctaatt 1829161 tcgtgtggct ttctacgaat tgatgggata gaattttttt agcgaggccg tcagcttcct 1829221 gattgtcttt tcgttgtatt gtttcgtagg ttggagtaag cttcagcgat tcaaggagtg 1829281 cttctatttt gtccagccat tcattatgag atggatcata acaaggccag ctgccgtcaa 1829341 gctgattcag cacaacaagc gagtcccctt tgattgtaat tgaatttctg cttgccccaa 1829401 gctctcttac ttctcttatt gcttcataaa gcgctgcgta ttcagcttca ttattggttt 1829461 tcagccggaa gcttttattt tttctcaagc gatgccgggt tcctcccaat gaataataga 1829521 tgacgatccc gagaccggcc agttcgctct ctttatcgaa actgccgtca aaataaacag 1829581 taatgtcatc aggctcttga gcaagctcct ctgtcagctt ttccaattcc ttcagcgtcc 1829641 agctgccgcc tttctcgtct tcgaactcta gctccttcat gtatggaaaa cggccaagtt 1829701 ctctggcgaa cgtacgtgcc tgctgtgctg tcagccagtc ttcgctaaaa aatgagacgg 1829761 atcccgttcc ttttgcttct attttcaaat gcggtctgag cttcattaca atcaccttac 1829821 cattcattag ttgccgggct tatgctataa tcaaaccaat cttaccccgg aaaggaagct 1829881 ttttcatctt gtttaataat tcgttttgga tcttttttgc gatcattcat tttatcattg 1829941 ttcttttatt ttataaagga tttggcaaaa tgggactgtt tgtttggatc ggttttgcga 1830001 cagtctgcgc caacctccaa gtcgtcaaaa cagtcgaact gtttggctta acagcgacac 1830061 tcgggaatgt gatgtatggc acaatctttt ttgcgacaga tgtgctgaat gaaaaatacg 1830121 gaccagctga agccagaaaa gcggtatggc tcggattctc aacgctcctg acgctgacat 1830181 ttgtcatgca gggcgtgctg cttttcgaac cggcttccag cgacatatca caaacagcgc 1830241 tggaaacgat cttcggattc cttccgcgag ttgcgttagg aagtctgctt gcctttatct 1830301 tcagccaaac gctggatgtt tatgtatatt cggcaattag aaggatattt ccttctgatc 1830361 ggcttttatg gctcagaaac ggcggcagta cagcagtcag ccagttgttt gatacattca 1830421 tattcactgc agtcgccttt ctcggcattt atccggcaga cgtgtggctt catattttta 1830481 tttctacata tttgattaag tttgcggtat ctttaatttc attgccttat gcctatgcag 1830541 ccaaaaaaat gatacctaat gatgaaagga gttcataatg cctacagaaa tatatgtaga 1830601 cggcgcaagc gccggtaatc cagggccttc cggtatcggc atttttatca aacatgaggg 1830661 aaaagcagaa tctttctcta ttccaatcgg agtgcataca aaccaggaag cggaatttct 1830721 tgcattaatt gaagggatga agctatgtgc aacgcgcggg tatcaatcag tttcctttcg 1830781 aaccgattca gatattgtgg aacgcgccac tgagcttgaa atggttaaaa atataacgtt 1830841 tcaaccgttt gtagaagaga tcatccgatt aaaagcggca ttccctcttt ttttcatcaa 1830901 atggataccg ggcaagcaaa accaaaaagc cgatcttctg gcaaaagaag cgattcggct 1830961 gaatgaaaag aattaaatct tgatcattgg ttcatcctaa tggcgaggtg aactaacatg 1831021 aaaaagaaag ataaaggccg gctgaccggc ggtgttactc cgcaaggcga cctggaaggc 1831081 aatacacata atgaccctaa aacagagctt gaggagagag caaaaaaaag caatacaaaa 1831141 cgctagagag gatctaaacg atctctctag cgttcagctt ttcaagcata cgctcaattc 1831201 ctttaatttg gtggcggcga agcatgtcag ccgcctgctc catttgcaaa gtaaataaag 1831261 cgtctttcag tgtgcaggcc agcggcactg agcaatggat ttccgcaagc ttcctcgaca 1831321 tctccaaatc gcttaaacct tgctgaattt ttccctgctg tccttttgga agaagagaaa 1831381 gattttccaa taaacggtca atcgtttcgt attcacgaat cagtttgtag gctgtttttt 1831441 ctccaatgcc tttgactccg ggatagttat cactggaatc acccataagc gctttaatat 1831501 caatcaaagc cttcggcatt acgcctgttt cttcataaaa agtctctttt gtatagactt 1831561 tataatttcc gattcctttt tgaagcaaag caacgcttac tttatccgtt aacagctgaa 1831621 gtaaatctct gtcccctgtt accaccgtaa tgtccgcttc attcgcaaat aaatcggcaa 1831681 gagtaccgat acagtcatcc gcttcatagc cggcaaagcc aatattcatg attccaagct 1831741 ctgcggctgc ttcctttgcc aaatcaaact gcggaatcag ctccacaggc ggcgcgctgc 1831801 ggttggcctt ataatcttgg aacaagtcat ttcggtacgt tttgctcccc atgtcccagc 1831861 agcagacgac gtgtgtcggc tggaatgttt ccacagctgt aatcaaatgc tttaaaaagc 1831921 cgttgacgcc gttcgtcggc accccgctgt catttatcat aaagttgcga tgtacggccg 1831981 tggcaaaaaa ggcccggaat aaaagagcca tgccgtcaac cagcaatagt ttattattat 1832041 tcatcaaata actccctttt ctttcattcc ttctatttta tcataaagca gcccaaaaat 1832101 aaaaaacagt atctctttaa ttagagatac tgtttgaata tttatcaatc gttgtgtctt 1832161 ttgttgctgg cgatcagctt ttcagcttcg cgtcctgcgt aagagtcaaa atgggtttga 1832221 aatccgtttt tctttttggc gttgttattc gcctgtgcat ttctgtttcc gagctttgtt 1832281 ctgcccaaca tgaatccccc cttacgtcgg atgcatatag tatatgcttc cggcaggagg 1832341 ttcactcgcg acaggatcat ccagcttaca tgcggcttac gtattctctg accatttctt 1832401 ttgatacaag ccgtcttgtc gggacgatgc cttttttagc gagctgattc atttgctcgg 1832461 taatttcatt aattgcatct gtagtataag gctcatcgtt tctgcattta gcaacagctt 1832521 cttcaatcgc caattcacgc atattttcaa gacgcataaa tgctttgata tgctcgtgct 1832581 gttttgatga atgtgctgaa attgctttat gtacctctga cattaatcgt tcatctcgct 1832641 tttttctatt tagtctatca tgacttgaaa tacaagccaa ctgaatttta catttttatt 1832701 gtattgtctg aatttttcca ggagatgcac gcctgatacg ccatttcaat ctctttcgca 1832761 tgttcccctt ccgcatatcc tcttaaatat gtctcttttt gatccgttat ttgcgcgatt 1832821 gctttttcac ccatatcttc ctgtaagcgt ctgaggtgag cagtgtaatg agatatcagg 1832881 ctttcttctt cattttttat ccatgcctct gtgattttcg taagtttcat ccgtacagct 1832941 tcgataaagg tcgcttttcc tttctgctca aaaaactgct tcggtgattt gatctctttt 1833001 agttcctgct caaaagcacg ttcttctatt tccggttcaa cttccttcaa ctgtatgccg 1833061 ttcgaatgct gatcacccgc ataaacggaa aaataaccgt cctcgtttaa tgttttttga 1833121 aaatgatcca gccattcttc attgatatgc cgttcgatga aaccgctcat gcgaacatca 1833181 agcgttttga tttcctgaat atattcaaat agatattcat gtaaggctgt tgtcatcgct 1833241 ttactgacgt tctttttcca atccccgttt tgcagcccgg gatgaaatgc cgattttaat 1833301 aaatcatttg caaaatatga taatcgctgt gcaatgtgat atagctgctc tcttgtatct 1833361 ttttttactt tttcaatgat ggtttttgag ttccgccgtt tctcgatatc ggccgctgtc 1833421 cgctcaaatg acagcataag gcactgtttc tgcgcttcct tctcttctcg ggactgatgc 1833481 tgggattggt gaagctgaaa aacagtttcg catagtttgt ctgcctccga actgagctgc 1833541 gctgctgacg ctttttttac atccacttcg ataaaccggt ctaagtgttt tcttactttc 1833601 gagaactgat tataaaatga ctccggtttt cccaccagtt cctccttact tgatacggta 1833661 aagagctgcg gctcataaac cccttctttt acaagctctg cgctgacata atcggtcact 1833721 gtttcgagct ctgttttatc ttttgcaagg tctgcagcat taataataaa aaacatttta 1833781 tccatgctga gcgattcttt cacaagtcca agctttcgca aaaatgaacg gtctcctttt 1833841 gaaaaagagt gctgataata agtcatataa aaaaatgcat cagcatcttt gatatattgg 1833901 aatgccagtt ctgtatgccg tttattcatg ctgctcgcgc cgggtgtatc aacgatcgta 1833961 atcccttttt cagtgagcgg gcatgtatag tagaccgtta cctctttcac agcacaggcc 1834021 gttgtttcct ctgctacata cggctttaat tcagagagcg gaatcgttaa tttcttctgt 1834081 tcctgtatat actgctgata cttctcgtat gcaagcagga aattgctgat caatttcacg 1834141 tgttcttcct gcagcctgtt ttttttgact gccttttccc acttctctgt gaaggaacgg 1834201 cctgccggct cctttggtat tccggtgagc tgcaaaattt cagccgttaa gtcatcctct 1834261 gtcttaaaca ctacattcgc tgttttgttt aagttgccat tgattggctt tgtgatcttg 1834321 ttaattgtcg ctgtggttgg cgttggtgag gatggcagca ctctttcgcc gacaagcgca 1834381 ttggcaaatg atgatttccc cgagctaaag cctccaaaaa gagcgagtgt aaatttccgt 1834441 tcctcaagcc ttttcaccct ttcacgaaac gctgaagttt gctttaacaa catgctgcat 1834501 tcgcctaaaa tgtcagacaa agtgtaaaag cgtttgattt ggtcttgaag cggcatttct 1834561 tgttccattt tgatttctga tttcggcatc ggctgcgccg tcagctggct tcggccttgt 1834621 ttctgctctg gagccgccac tcttgttttc ttcgatttaa accattctgt gtctatatgc 1834681 attgggcatg cggactcttc ttcccaaatg gcccacaggc gatcggtttt ctctcgggca 1834741 ttattctcta aacgtgcctg ttcttgaaga aagacaagtt tttctgattc ttggacgagc 1834801 cggtcgttaa ttgtttgcac atctttggaa acacgctctt tcaccatagc ggagagcacc 1834861 tttatgatgt ctgcggcttc tcttttcgcc tctttccgga tgagctctgc caagtctttt 1834921 gtatattgca atacatattc agaggaaaag gctgcaccat gcttgaccgc gtgttcaatg 1834981 atgcttatat caagcggtgt gcgataggcc tgaatcagct tttcactttc agcggtatag 1835041 acatcaaata ccttggcgag tttatgaagc gtgtctatca tatgccaatc cgcttcggcc 1835101 tctgttcgtt ttgccacatc agagaaaaaa gcattccgcc ttttatctct ttcctgtgca 1835161 gttttcgctt tagaaaagaa aaagccggtt ttaaaggaag gctcttgtga ttctaaaaat 1835221 gcagccgcca attcacgcat ttcaaaaggc gtcaggttgg cgttttttaa aatacgattg 1835281 atttcttcct gcatcctctt ctctgcctca gtcatttgtt tttcggcctc atccaattga 1835341 tcacgcagcg attggaccag tccagtatgg atattaagct gttcagcgaa actcggagcg 1835401 cctgtttcgt ctttcttcag catttccgta tgttccttta gcagattacg gactttttgt 1835461 tcggttaaag cctgcatatt gctttttgat tgctgttcta ttctgcttaa ctcttctctc 1835521 agggccccca tctgattgaa cgggtgatcc ggttctgtta ctgatgtaaa atagagcgct 1835581 tcccttgaaa tcccttcatt gcaaagcatc tcctctacct gcgcttgata gtctccaaat 1835641 ttcgtctccg tctcatcatg gcggtcaatt tgattgacga taaaatacac attcggaatg 1835701 ctttctttta ttgatctgag aaactttaca ttttcctcag cgtgcacgtg attatagtga 1835761 acgacgtaaa acagcgcatc cgcttggtga agaatagaag cagccgatag aaaatgcgca 1835821 tcatctgttg aatctatccc tggagtatca atatacgcaa ccccggaatc gatctcagta 1835881 tacctgtcaa aaatttcgac gctttcaatc tgttccccgt ctttacaata ttgctgcacc 1835941 ttgtctttct ggtaagtccc ttccagctca gcacacgctc cgtctgttgt atgaagccga 1836001 actcgctttt ccccgtttct gatcacaaca aggttagcgc ttgtcggaat cgggcttgtc 1836061 ggcaaaatat tctccattaa caggcagttc agcagtgacg atttccccgc tgaataatgc 1836121 ccggtaaacg cgatataaac ctcttcatca gccgcttttt tcatgaccgc agccagttta 1836181 gcagcccttt gttcatcttg attctcaata aattgcttat aaagttcccc ggttttatgc 1836241 aaaagctctt ttctgttttg atctgtcata agtctgaacc cctttgtgcc gtttcaattg 1836301 tgaacctttt tcgaaagatc tgaattcatt cccttttcat tttacacaag aataaaccaa 1836361 atttctttag gagaatagaa aaaagccgcc attacggcag cttctataaa agaaaatctg 1836421 caacttttac aagttccaga ttcatcaaac agatttatta gagattcctt ttaatacaaa 1836481 accaattaat acactatatg tacaaaccgc tccaagcaaa aacagcattg tcatttgctt 1836541 caccatcctg attgagaatc tttttcaaac ccattttaac atggttgaga atgattttca 1836601 atcgctattt tacgctgtat tcctgtaatg ctttgtcttc tgcgcgaatt ctgacgctta 1836661 acaacacggc attgaaaatg gaaaacagac acatggtgac gtatgcttga taaagcagcg 1836721 gaatcagcaa aatttcgagg ataacaacgg catagtttgg atgtttcatc catttatatg 1836781 gacctttttt tacaagctct acacctggaa caacaaggat tttcgtattc caatatgctc 1836841 ctaaggaaca aagcgcccaa taccgtacga tctgtacgct taaaatcact gcagcgatac 1836901 cgagccacca gctggacggc tgtttattca tcagcagcac ctcggcaatt aaggacagga 1836961 aaaaaaggat atgcatcgta atgatatacg gatagtggct ctcgccaaat tcaattgctc 1837021 cttgcttctt taccttttgt tcgttttgcc tggccactgc catttctgct gctctttgaa 1837081 caatgagaat ggcgatcaac aaccaaaaca tgagtcaggc ccccttttcc cagctgaata 1837141 atagcaactc tgatgagaaa cccggcccta atgcgccaat cagtcctcgt tcagcttcct 1837201 ttttatgtcc gttctgcaga tggtctttga tcacatacaa gattgtggct gaagacatat 1837261 ttccgtgctt ttgcaaaatg ctttgcgcag atgaaagctt ttctgacgac agcccgagac 1837321 ttttgatgta tgcatcgatc actttttttc cgcctggatg cgccaaaaaa acactgatat 1837381 catggaatga cagcttatgt ttgtccaaaa aaatctgtac atttgttttg agccattttt 1837441 ccaccaaggt cggaatgtct cgtgagaaaa tgactttgaa tccttgatcg gtaaagtccc 1837501 agcccatgac atcttctgat tgtttcatca aaacagattg ggcgtccatt atcttcggcg 1837561 caagcttcag ctttgacacc ctgcggtccg ccttctctcc gcataataaa gctgcggcaa 1837621 tgccgtcacc aaaaagcgag gtgccgatca gattgctttt tgttttatct tccggctgga 1837681 atgtcaggct gcacagctcg gcagaaatga caagcacaaa agcctcagga tacgctttgc 1837741 agtattcggc tgcacgcgca agtccgctgg ctcctcctgc acagccaagc ccccaaatcg 1837801 gaatccgctt cgtatatgga gaaaacggaa gttcattcat aagccgcgcc tcgatactcg 1837861 gtgtggaaag acctgtactg gagacgaaaa aaacagcttc cactttctca taaggaatgg 1837921 cttcttgaaa aaattccgga tgagagaggc actcacgaac agccgctctg ctgtgtttaa 1837981 gtgtttcttc tatgtatatt tgattttttt cttcaaagct gtgcccctct ttataccatt 1838041 caatcggctt aacaaactgt ctcgaatgga tttgcccgtt tttaaaggag gataacagcc 1838101 tgtcaatatc cttaaaagaa tgctgaaaca tatagcgggc gaactcggcc gctttctctt 1838161 ggtttacatt atacgcagga agacttgttc caatggataa aataaacgcc atgcgatcac 1838221 ctctttgcat acattgtgcc gcaacaatct tttttatatg caaaaaaaac tccgccgcgg 1838281 cggagttaga ctgctgtttt ttgttcagcg aggtcagctt cttgttctat ttttttagct 1838341 ttagaaaaaa cgttatatac aatatttaag acgactgcag taaagctgcc cgccacaatg 1838401 ccattcgttg taagcagcgt taaggcactc ggaagctgtt tgaaaatatc cggcacaacg 1838461 gtcacaccga gccccaatcc cactgagcaa gcaacaatca gcagattttc ctgtttcgca 1838521 aaatcaatgc ggctgagcat tttaattccg taagcaatca ccattccaaa catcgccacc 1838581 attgcaccgc ccaaaacagc ggatggaata atagtcgtga aagcagcgat ctttggaaac 1838641 agcccaaatg ccattaggat cacacctgtg accacaatga cggcattttt tttgatccct 1838701 gtgagctgaa caagcccgac attttgagag aatgccgtgt aaggaaaagc gttaaaaata 1838761 ccgcccagaa gcacagccag tccttcagct cgatagcctt tagacaaatc tatctctgtc 1838821 aaacggcggt ttgtcaggtc acctaaagca aagtaaacac cagttgactc cacaaggctg 1838881 acaattgcaa cgatggacat cgtaatgata ggcgctgcgt gaaaagacgg cgctccgaag 1838941 taaaatggct gaatcatttg aacaactgcc gcgtccgaaa cattatcaaa ttgaactttt 1839001 cccataaaat atgcgatgaa ggtgccaatc aaaataccga tcaaaatcga gacggacttg 1839061 ataaagcctt ttgtaaaacg gtatagaagc acaatgatac tcaacacggt aaaagcaagt 1839121 gcaagattgg agagatctcc gaaatctgca cttccttctc cgccggccat gttattcatg 1839181 gcaaccggca tcagtgtaat accgataatc gtaacaacag agcctgtcac gaccggcgga 1839241 aaaaacgata cgagctttcc aaagaaaaat gaaataagaa tgacaagaat gcctgaagcg 1839301 ataatgctgc cgtaaactgt tgaaacccca tattcagatc caatcgctat catcggcgat 1839361 acagctgtaa aggtacagcc aagcactacc ggaagcccga tcccaaaaaa tcggttgctc 1839421 cacacttgca gaagtgtagc cacaccgcac ataaaaatat caatcgatac taagtaagtc 1839481 agctgctcga cagtcagtcc cattgctttt ccgacaatca gaggaacgac aatggcgccg 1839541 gcatacatgg caagaacatg ctgaatccct aaagacagcg ttttgccgaa tccatttctc 1839601 atgaatgaac ctcctgtacg aaggacactt ttccttcttc taaagactga attcttgcca 1839661 aagattccac tcggtagccc agttttacaa gttcatctct tcccggctga aatgactttt 1839721 caataacaat gccgattccc gcaatagaag ctcccgcttg cttcacaatc gacacaagcc 1839781 cgtgcgctgc ctgtccattt gccaaaaaat catcgataat cagcacatga tcctgatccg 1839841 acaggtgggt cccagacact gcgatttggc tttctgtttg cttcgtaaag gaataaacag 1839901 acgctgtcag caagttgtcg gtgagtgtta acgatttatg ctttctcgcg aagacaactg 1839961 gcacacccag cttcaagccc gtcattacag cgggagcgat acctgatgat tcgattgtca 1840021 caattttggt aataccgtct tttgcaaacc tagacgcaaa ttcatcacca attctctgca 1840081 taagcagcgg atcaatttgg tgattcaaaa aagaatccac tttcaatacc tgatcagata 1840141 atacgacgcc ttcttcctct attttccgtt tcagtgcttc catcctgtct acctccgtta 1840201 tgagaataaa aaaagcattg cccgctcaaa taaagagcaa gcaatgctga tatcacaaaa 1840261 aaccgtacac gtgcggttcc attgctcacc catagtcgga catttacggt gcccggtaga 1840321 aacttgcgtg ccatatccac gcgattatat gagtgttcct attatattgt aataaattat 1840381 atcaagattc taatctcttg cataggctga aaataaaaat tcccgaactt taattttgtt 1840441 tttttagata tcattcgtat ttcaagggga ttcgatataa aagagtctga cgaccgcgcc 1840501 gccaggcttt tgattataac agatagagat ttgaatattt gtttgataaa taatcaatta 1840561 aatagcgaac attcagctct tctcctgttg catctttaat aatgtctaac ggctttttcc 1840621 gttttccgtg aatgtgcacc ttttccgtca gccattgctt tatcggatgg aactctcctc 1840681 tttccaagag agcgtcaaat tcagggagat cctcaagcat tttttgtttc agctgagccg 1840741 catacatgta gccgagcgca taggatggga agtagccgaa atctccacct gcccaatgga 1840801 cgtcctgtaa aatcccctct gcgtcggtct gcggtgtaat ccctaaataa tcctggtatt 1840861 tttgattcca aagcgacggc agatcttcca cagacacttc attgctgaaa atcgcttttt 1840921 caatttcata acggatgatg atatgaagag gatacgtcaa ttcatccgct tcgaccctga 1840981 taaatgaagg ttttgattca ttgattgccc ggacaaaatc atccagggag atgtccttga 1841041 actgtacagg tgatgcctct tgaatcttct tatagtacgg agtccaaaaa tgcttgttgc 1841101 ggccgataaa attctcgtaa aataatgatt gcgattcatg aattcccatc gatgcgccgt 1841161 ctgacaagtt cgtgccactg agtgcttcat caatattttg ctcgtaaatc gcgtgcccgc 1841221 actcatgaat ggtcccaaag atcgccgtcc ggaaatcttt ttcatcatat ctcgtcgtga 1841281 cccgaacgtc tccccgattc agcgtagttg caaacggatg aacggtttca tcaagtcttc 1841341 cgccatcaaa atcgtagcca agctcctgta aaaaatacag actgagctct ttttgctttt 1841401 ctttcgggaa cgcttttgta ataaagcttg tatctggttt atttccggaa gctgtcacct 1841461 gtttaacaag agggataatc gcttccttca gctcagcaaa caactgatca agcaccttta 1841521 ccgtgacgcc gggctcaaac aaatcaagca atgcatcata aggatgctct tgatatcccc 1841581 aatacgtaat aaaacgttta ttgaattcaa tcagctgttc taaataagga gaaaacaagc 1841641 tgaaatcaga ttttcctttc gcttcctccc acgctgtttc tgcctttgaa cacagaatca 1841701 cgtattcttt gtattcagcc tcagggattt tcttattctc ttcatactct tttttcgcca 1841761 gttccactgc ttttttcgta tcttccgaca agtcatcaaa tcgttcatac aggacatcga 1841821 taagctcctt cattcgatct gatgtttgga tattgaatat atctgttgaa agctggccga 1841881 tactttcggc acgatcctct gagccatttt tcggcgcgcc tgttctggag tcccagtgca 1841941 ttaacgcaac tgcttcgctg taatgtgaga ttctttttaa aagatcaaaa aattcttttt 1842001 catatgtatg tatctccata tccattccct ccctattcta gccgttccat tacaggctaa 1842061 tggaaggggg tatgaaagtc aaattgtttg tataaaaggc tgccggtatg ttttgtggca 1842121 gcctttttat tcagttgatc gtcatttgat tttttggcgg aggtgttctc cgctttttct 1842181 gcttgatttt tttatctacc cacactgttg ccagcggggt taagagcgag gtgacaataa 1842241 cgcttgtcgc gataattgca gttgccgact cagcaactgg cgcaaatgag gcattcgctt 1842301 ccgctaatgc atatggcacg gctacagccg cccctgccgt agaagaagcg gccactcccg 1842361 cgacaccatc tccccgcgca ataaaacgat caagcaaaaa caaagaactg cccgataaaa 1842421 tgacgacaga aactccgata aaaatgccga gcagccctga ttggatcagc attccaaaat 1842481 tcaaggtatt gccgagcgaa aaggcgaaaa atggaatgat cgccggcaca accttgctga 1842541 ataagtctct gagatcatga tccagatttc caagtataca tccaagtaaa aacgggatga 1842601 ctgtcgctgc cagcgtttcc catgggaatg cggcaagtcc cgtcacacca aacgtcacca 1842661 tggtcataaa aggaccagat tctgtactga taaaggcgaa agcgcccgca tcctcttttc 1842721 ttcccatgtg attcatgagc gccaaataca gtccgccgtt cgtttcattc attaccgcga 1842781 caattgctaa aacagaaagg cctgcaaaaa agccggattg tatgccatcg tcaggtataa 1842841 attgcgctgc gatcacgccg agcagcgccg caaatccgat cttccccaat aataacgtga 1842901 ttccttttct tgcgatatag cctgaagaac gaaaatcaat cgttgctcct acgcaaaaga 1842961 taaaaacacc cagtatcggc agcgttccgg taatcaaagc acccgtaaac cctccaaaga 1843021 actccgctgt tccaggcgca aacgtgttga gcgccgctcc aagaaatagc ggaataatca 1843081 tcattccgcc aggtacccgt tcaattgtcg ccttgatttt catattgtgg attctcccat 1843141 cctccggtta tgaaaaaaca attccactta cacttggaaa acagcctgca aatcctcttt 1843201 tgaacagctg cccaactggc tgccgactcc gacggcgcca gctccggctc taagccaatc 1843261 aggcacttca gacggatgta tcccgcctgt cggaataaag gtcacctgcg ggaaaggacc 1843321 cgctaaattt ttcataaacg gaatgccaaa cacaccgctt gggaacagct ttaatgtcgt 1843381 aaaaccgaat gtcagcgctt ccataatttc gctcggagtc aagacgccgg ggatataatg 1843441 tgtctttaca aaagatagat gttcagcaag atcagctgaa aaacccggac tgacaataaa 1843501 ctgcgcgcca gccttagcag cttccccagc ttgctgcgcg ctgatgaccg tacccgcgcc 1843561 aattaaaata tcttccctat tacggaagga ttcgataata tctgatgccc cgggggtcgt 1843621 atacgtcact tcaactgcac gaatcccttt atctaataaa ctctcaatct gctgacaggc 1843681 ctcctgctta tcctttgaac gaatgactgc aatcagcttt gcttctttca gacggttttc 1843741 aacgactttg gactccatat taataatccc ctttcttttg gtgaaccgtt ctttgagcag 1843801 ataaaaaaga agctaatttc tccctggtcg gcaaaccgtc catatccccc ggtgcctgca 1843861 cttgcaaagc gccaatcgca tttccccttt gcaccgcatc cttgtacgac aaaccgtcta 1843921 ggataccgct gattacaccg actgcaaatc cgtctccggc gccgaccgta tcaaccaccc 1843981 ggtcgacccg gcagccttct agaaatcctt cacttgtccc cgttttaaag taagcgcctt 1844041 cttttccaag tttaatagca acaaagctgg cacctttttt caaataatag tcggcaatgc 1844101 cttcaggtgt tttttctccg gtcaatagct ctccctctgc gatacccggg aaaaaccagt 1844161 ctgcaagccc agccagatca ttgattgtgt gtaccattgt tgcttgatca ggccaaagcg 1844221 aaggtcttac attagggtcg aatgaaatgg tcttccctgc gtttctcatg tcgttcatga 1844281 catgatacgt gaagtctttc atctcggctg ataaagcagg cggaatacct gtcacatgca 1844341 aatggcctgc gcattgaaaa taatctctcg gatattcagc tgtagttaat gtgcttgcag 1844401 ctgagttttt cctatagtag gtaacttgcg ggtcgccttc tttcactttt gacttcagca 1844461 gcagcccggt gggattttcg tcctgcgagc ggatcacgcg ggacacatcc actccctctt 1844521 ttttaagctc ttgtaaaata aacgttccga gctgatcatt gccgaccttg ctcatccatc 1844581 ccattcgaaa tccgagtctg gcaaggccgc aggcgacatt gctttctgct ccggcaagcc 1844641 ctttagaaaa agtggatact tcatgaaggc ctccatactc atttgcataa aacatggcca 1844701 ttgattcccc gaatgtcacc gcatcaagct tcatctcttc ccaacctcct cttagttgag 1844761 ggcacctagg attaaagtga ctttctcatg atgacttttg cctctaattc aatggtttga 1844821 ggcgctcctt tgtcaccttc aatccttttt aatacacgtt ccatcgccgt cctgcccata 1844881 tcatgtgacg gctgggcgat cgttgtaatg cctggaccga tcagtttgta ccactccgta 1844941 tcatcgaatc ctgcaatccc tatatcttga gggatgcgca ggccaagctc ttccatacag 1845001 ctgatgattt tcagcataat caagccattc aaagccagaa tcgctttttt ttgctccggc 1845061 atttccttgt gaaaagaacg aagctccgcc ttaagctgct ccttgtcctt tacgtcaatt 1845121 tcatgcaatc tgacaagccc gttcacattt tgaaccgaag ccatttcctg atacacagct 1845181 gctctttctg cacgagggct gatagaggaa atcggttcgg taaacagcgc gacatcagta 1845241 taccctttgc tgtacacctt ctgaagaatc tcttttgtga tccatctgtt gtcagtcgtt 1845301 acggtatcca gtttcagatc cggcagtttc cggtcaatta agattgttgg aatttgctgt 1845361 tcagcaaaag cgcggagtac atccttgttt tcccctgttg cgtttaaaat caagccctca 1845421 accgaatggg cttctagctt taagagcatt tcccgctctt tttcaggact gttatctgtg 1845481 ttgcacacca taatgctgta tccatattga tcacaaacct cttcgactcc cctgaaagca 1845541 gcgaccgaaa aaggatttgt aatgtcagcc acaacaaatc cgattaactt gctttttttt 1845601 attttcaaac cttgtgccat tttactcggc cgataattca attctgcgat tgccttttta 1845661 atgtttttca ctttttcagg agaaatcgcg tcaatttttc cgttaatata gcgggaaact 1845721 gtcgatttcg aaactcctgc acattcagct acgtctttga tggttgtatg gcctgttgtt 1845781 ttctttttca ttcaagtgct cctgtatctc atatatttga aaccgatttc aaaaccgtta 1845841 caacaaaaga ataccataat tttaaaattt gggaagagtt tttttaataa tatgtcaatt 1845901 cattattttt tcgttgactc ttttcactat ttatcctaaa attttctttg aaaccgttac 1845961 caaaatattt tcattcaagt gatgctgaaa tcctaaccaa gggggaaata taatggaaaa 1846021 tcgttattct gtacatcctg aacaagtaaa acgctttaca acagaggagc ttcgcagtca 1846081 tttcttaatg gattctttat ttacagaaaa caaacttacg atgtattact cacatgaaga 1846141 ccgggttgtc atcggcggag cggctccagg gcaaagtgaa ctgaagcttg atgcaggtga 1846201 ttttctaaaa acagacttct ttttggaacg gcgtgaaatc gggattatta atgtcggcca 1846261 gcctggtgcc gttagagtcg gcgatgatga atatgtgctt caaacaaagg attttctcta 1846321 tattggaatg ggcaatcagg atgtatcgtt ttcaagcctg aacggggaaa aagcgaagtt 1846381 ttacttcgtc tccgcttgcg cccacaaaag ctatccgaca caaaaagccg ccctatctga 1846441 actgacaccg gaccgccttg gtgatgatgc agcgtctaat gtcagaagtc tgtacaaagt 1846501 cattcatcag gatggcatta aaagctgtca gctgatgatg ggaataacga tgttagatca 1846561 aaacaacaac tggaatacca tgccagcaca cgttcatgac cgtcggatgg aggcttatct 1846621 ttatctggat cttgaaaagg actcaaaggt atttcatttc atgggccagc cggacgaaac 1846681 acgccatctt gttgttggaa atgagcaggc tgtcctttct cccgcttggt ctattcattc 1846741 tggcgcagga acatcaaact atagctttgt gtgggcgatg gctggagaaa attacacatt 1846801 tacggacatg gatctcattc caatggatgg gctgaaataa gatgggttat ctacatgacg 1846861 ccttttcatt aaaaggaaaa acagcgctgg tgacaggccc gggaacaggg atcggtcaag 1846921 gaatagccaa agccctagcc ggggctggcg ctgatattat cggcacatca catacaagca 1846981 gtctgtctga aacacagcag cttgtggaac aggaaggccg gatatttaca tcttttacat 1847041 tggacatgag caagccggaa gcgataaagg attctgcagc tgagctgttt gaaaacaggc 1847101 agatcgacat ccttgtcaat aatgccggca ttattcatcg ggaaaaagcg gaagattttc 1847161 cagaagagaa ctggcagcac gtactgaatg tcaatctaaa cagcctgttt attctgacac 1847221 agcttgctgg caggcacatg ctgaaaagag gtcatggaaa gattattaat attgcctctc 1847281 tcctgtcttt tcaaggcggc atcctcgttc cggcttacac cgcgagcaaa cacgctgttg 1847341 ccggtttgac aaaatcattt gcaaatgagt gggcagcgtc aggtattcag gtcaacgcaa 1847401 tcgccccagg ctatatttct actgcgaata caaagcctat tcgggatgac gaaaagcgaa 1847461 atgaggacat tttaaagaga attcctgccg gccgctgggg ccaagcggat gatatcgggg 1847521 ggactgcagt ctttttggca tcacgtgctt cagattatgt aaatggacat attttagcag 1847581 ttgatggcgg ctggctatcc cgctgacaaa taaaaaagct gacgaacgat cgtcagcttt 1847641 tttccattac atcatgtgcg gttcaacagg caagaccttt ttgacctcat caatgatgcg 1847701 ttcattttct ccgccagcgt aaatgtgaat cgagccgctg tcttgattcg agcgaatcag 1847761 gcgcccgatg ccctgccgta cacgtaacaa catatatggc agatcaactt cttcgaacgg 1847821 atcttttttc gctccgttgc gcttcgctgt aaatacagga tcgtgtggcg ggaacggtaa 1847881 tgaccaaatg gtaacattct tcaatgcgtc accgggaatg tcgagtcctt cccataagtg 1847941 aactgaacaa agtactgttt cttcttcctc ttggaatttc tctactaagc tgctgatttc 1848001 ctcatcacct tcgaagaaaa ttggatacgg cagctcccat gccgccgaca gctctttaaa 1848061 ctcgtttaat tcttcaaaag aagggaaaag caccagcgtt cttcctttgt atcgtttgat 1848121 tgtttcaatc gtttcagccg ttttttgttc agcgtccata tctgtttttg cgtatagatt 1848181 aatactcatt tgctcgtcat aatcataagg ggaatcaaca gttaatgaca aataatcatg 1848241 aatcccaaga ctgtcggcaa tataatcaaa cgaaccgcct tctgacagcg tagcagaaga 1848301 aaagatataa ggaattttct tagaaaacac tttttcgcca agtacttctg ctaccgttct 1848361 cggcatcacg acaaaggttg attctgcttc ctttttctcc agccagctga tcgcatcctt 1848421 ttgatataga gataatgaat acgccatttg ttcaacatat tcttccacta ctgacagttc 1848481 gtattgatca atcgtataca tttcagactc aaatacaagt gcctcaccga ttttatcaag 1848541 taaacggcaa agctcgtccg ccgccttttt gacacgatgg tcatttttta tttctaaacg 1848601 gtgtgaaccg gctacttcct ttgattcttc agaaagaaca tagaaaaatt cgtcgtttgc 1848661 gagaagcgca tcttcaatca attctgcaaa ctcttctctg atgtcatttt gcagcaatcg 1848721 ttctaaaaac aattcaagag tagactgctt cactctatag gttagcgctt tttgcgcagc 1848781 aaactctaac aagtgcccct catcaaatac aactgcacta tgatcaggca agagcggcag 1848841 ctggccctct cgtttgcgtg attcttccgt ccacacatgc tccatataaa aatcatggga 1848901 acaaatgatt aagtccgttg acttgcggta gtaatctctg gaaagtgtca gaccgcatct 1848961 gtgtctcata tcacaagtca gacagtcctg aaacgagtcg tagcttacgt cagaccactc 1849021 ttcattcgat agatttgcgt actgcttacg gtcgccatac ggataaaagc gctgcatcgc 1849081 ctgggactcg tggacaaatg acggtaacga ctcataaaga tccagccatt tatcatcatc 1849141 agaacgctgc attgtttttt caagcttctt caagcataaa tattgctcat gtgattttga 1849201 cagccttgta tcaattttca gatcaagatg ctcagccagc ttagaaatat cgccctcttt 1849261 tttcaccagc tgttcaatta atgtttcatc cgcacaagcg atgatggcag gtttgccgac 1849321 ataccttgca tagctgattg caaaaagaag atataccagc gttttccccg ttcccactcc 1849381 agcttcggcg aacatgactt ttttctcttt aaacgcccgc tccagctgaa aagccataaa 1849441 tacttgctcg tcccgaagat caaacccttt ttcgggaagg atatcgtaaa acacgtcacc 1849501 aatccaattg ttcaattctt cataaaaatt ctttgttttc gttaaagaaa aaggcaaacg 1849561 tgatgttgtc acctagttcc aacccccaac tattcgacat tcagaccacc aataatatca 1849621 ttttccgctg atgaatacaa taaaaaactt ggcaatgcca agttttttgc agtttactta 1849681 cgattgatca catgcgacga taaaaaagga tggtctgttg aataaatatg ttctaccgct 1849741 ttttctaaat cagtttgcgc atgcgaaatc acagacggag acgaatcagt cccgagctcc 1849801 ttcagctcgt ttgctgttgc gtcaagcgcc ctttgaataa gattaaaatg ttcgctgttc 1849861 agcatgagat cacctctgat ggaaataatc atcattgtat gcgaactttt cattttatat 1849921 acatgcttta ccgcatgtta tcaccgaaac atgcacaaac tacacttgat attccgtctc 1849981 cggattatcc gtcttatcaa caatattcta tcagggagtg atgttgacat gagttataga 1850041 aaccgattag atcagcattc tgaactgttt catcacaatt ggacgcggcc taaacgttca 1850101 aagtctcaag taaacggtca cactgaaatg tcccaaacca acattatatt gagaagcaac 1850161 gcgaaagctc accgttggta acgatagaat agggctgaaa gatgaaagaa gacgcatgca 1850221 gagcgtcttc tttttatgcg ttttctgttt tcttgcgctg cggtcttact tttgaccagt 1850281 attgataata atccgtttta ataaacccgt taaagagttt tcgtttcttc gttgcttttc 1850341 tgccatatgc ttcctcaaag ttttcatttg atgtcagcat atacacagac caagtatcaa 1850401 gcggctcgaa cgcctgcccc atttctttgt acatctgctc aacggctttt ttctcgccga 1850461 gacgctctcc atatggcggg ttgccgacaa ttacgccaaa ttccagattt gtggtaaagt 1850521 ctttgacctg catctgtttg aactggatta gatctcccaa tcctgcttcc tctgcatttt 1850581 cttttgcgat ttgaaccatg cggtggtcta tgtcgctagc gaaaattgta agcggctgat 1850641 cataatttgc cttttcttcg acttcaagcc gcgctttgtt ccacagatct ttaccgatcc 1850701 attcccaatc ctctgataca aaatcgcggt tgaatcccgg ggcgatgttt tggccgatta 1850761 gcgccgcttc tatcgcgatt gttccggagc cgcagaaagg atcaacaaac gggcggtcag 1850821 gcgtccaatt ggttaattgc accaaagcgg cagcaagtgt ttctttaatc ggcgcaccgc 1850881 cctgatcgac acggtatcct cgtttgtgaa ggcccgtccc tgatgagtcc agtgtaatca 1850941 aagcctgatc tttcaataaa gatatttcca ctttatactc agcacctgtt tcttcaatcc 1851001 aatcattggc tttgccggac tgcagcttga gcttttcgac aattgctttt ttgacgatcc 1851061 gctgacagtc aggaacgctt gcaagtgttg attttaccga ttttccgatg acagggaatt 1851121 tcccgttttc aggtataaat gagcgccagt taatcgcttt cgttttttca aacagttcat 1851181 caaatgtttt cgctttaaaa gaagcaacct gaacctttat gcggtcggct gttctaagcc 1851241 aaaggttcgc acggcagatg gcaagtgcat caccttcaaa aataactttc ccgttatcaa 1851301 ccttgcattc gtatcctaaa tctcgtactt cctttgcgac aacagcttca atgcccatcg 1851361 gcgccgttgc aattagtgta tacttcttca tcgtatcacc ctgtctttta aaacttttct 1851421 cttttcaaga taaaagctct ccttatacgg gagagcttgt tttcatcatt ttaaatgtaa 1851481 gtggtctaac gttctgtaag ccatgttttg ttccatcgta ctgcaaacgg ctcatcacct 1851541 cgtactcagg cggcaatcat ctatctacag aaagcattct gtccttctct ccgttgaatt 1851601 ccgttaagaa ggttccccta ccaaaatttg ggtttctcgc tcgaggggtt taccgcgttc 1851661 cactctcacc atttctagtg agacttcgtc actgtggcac tttcaaggat actcagccat 1851721 atccgaagac gtaggctttt ttcctgccgt cagcctctaa agactgccct agcttatgac 1851781 ttcgctaggc acgaacacta cgggcatctc agcaccgtgc gagcatggac tttcctctac 1851841 agattcaaga tctgcagcga ttacccgaac gttaagaaca tgaattatta tataacaact 1851901 gattacaatt tacaagcgcc atttttttca agcgtgatca atcataaagc ttgctgccaa 1851961 aaacgtgttt ttctaagtta gacagccgtt ttaaaatatc aaagtttgtt gtgttagatt 1852021 gcacaggctg ttttttgctg gcttcttcaa gctgtttttt cagctgcaga ttttcctgct 1852081 gcagttcttc aatttcttga tggaaggttt cataatcctt aataatcata tctaaaaatt 1852141 tgtcaacgtc ttcttgcttg tagcctctaa cgcctgtttt aaattctttt tccaaaattt 1852201 ctttcgcaga aagctttact ttatcagcaa gcatcttttt cacctcgtat cgtgaatcat 1852261 cacatatatt ttttcagaaa tctgtacggt tgtcaaattt ctctctcatt gttagtagct 1852321 gtcttcctcc actgtcactc tcaagtcatc cattgtaata aagtagatgg gatagccatc 1852381 ctgttcgcgc cttttttccg ctgtcccaag catatactta ggggagcctt ccttttccgg 1852441 gtcatataaa agcagaagcc cgtcggactt atcaatgaag aactgatttt tttgtttgaa 1852501 ttgaagcggg ctttcataag gacggtgagt caggcttgct tcatagtctg cctgagccag 1852561 aactgcttca tactgttctt tattcggttc tttccagttc ttttcctgct cgtaaaatgg 1852621 tgtgatgaca gctaccttta agtcagggta ttcctcctgc aaatcatatg cagcttctgc 1852681 cgcccacagc tcaactccaa gctggcccga aattaaaatc cattctaatc cttcatccaa 1852741 aaaagcaatc agccggtttt taatggcttt ttttatgtaa tacagcgcct tgtcatcctg 1852801 cttaaatatc cccagttcaa acggtttata gcccgttatt gccaatactt tcatcatttc 1852861 acctgcttta aaaaatgggg ctcccgtggg ccccatttgt tgtgctgcat tgtttacacc 1852921 atcaagctgc acgttttcca tactagtagt cgcagcaagg ttttcctgct tgaaaatgct 1852981 gatgcgtagc cgggtcaaca tttgagaaag tgtgtggaaa gtagtgaacg tgctgaaaat 1853041 gctggtggtt tacgtttgtt gtatgctgtg ggtgaatgtg cggcacgata gtcttcgaaa 1853101 acgtatggtg ttcacagcaa tgagtaggat ggacaattgg cgccatcata tgcggtctgc 1853161 agtgatgcat gataaaatcc cctttccata aactttatta caatactaag ttatgaaaaa 1853221 taaggggtac atgttctgat gcaaagacct attttaaaag tgtgcaatta agctgtcttt 1853281 aaagtttgaa aacacaaaag caatcaaaaa taccacaaca aagaacaagt aaaaaacacc 1853341 cttatacata ccaactctcc ctttaaaaat aactaacgtc attttacagg attcgccgct 1853401 attctacaac aaaatcaatg tgaattcagc aaaaaaaatt catggcgaaa caagtcgtct 1853461 tttgcgcttt cccggggaat atttaagagg aatatttcct ctttagccgg gcaattctca 1853521 catgcagttt ttcagtttct ttctctgata agcatgccgc atcgctaagc gattgctctg 1853581 ctacttgcaa tgcttttccg aattcttttt tcttatgctc aaaatatttc gcgagctcta 1853641 ttacagcagc gtatctgcac ttctggtttt gcgagcggga cagcttttcc caaagcggca 1853701 ctgcttcttc caagcggttt tgttttttgt acaggagcga taaatccagc cgtgcactgt 1853761 cctggtcctc aaacgatttt tctataagcc tttccaactg cttgatcgct tggtccgttt 1853821 ctttatgagc cataaaccat ttcgccatag cataggcttc actgtgttct tttggcgcat 1853881 gtgattctga aaggattttt ttagacatat ggatgtacaa tgaaatgagt gataacacat 1853941 ccatttcatt atgatgcagg acacctttta aaagatccgg ctcttgcgcc ttgataaaat 1854001 gaaagtaaag cattggcgcc aagtagcccg gtgtgtcttc tagcctgcgg atgccgagct 1854061 cctctttttc aaccgtgcca agagatacac ggtccatttt gtgtttccac aggcgtctag 1854121 ctccatgcaa aagatcaaag tggccaaact ccggaagctt cggaagtctg tcacggatca 1854181 aggtgtgcct tgttttcacc tgcggccaat caaaggcttt gccgttgtag gtcacaagtg 1854241 atgtaatgtc aacctcgctt aaaaagcttt ggtacaaggc gacttcgttc cccggtttgg 1854301 gcaaaagatg ctgtttgact gtcactcggt cttcatatac tctcgcatgc ccaagcaaaa 1854361 aaatggtatt cccagctcca cccccaagac cggttgtttc tgtatcaaag aaaaagaggt 1854421 tgtttttgtt ataccctttt gctgacaatg tatgcgacag gccgctttga ttccacagtg 1854481 tgatcacttc ctcaagctca gaaaagctgt ataacccatg gcggtgagaa agcggatatt 1854541 ctacttctct gatgaggcaa tattcatctt cgaagatgaa aggcttcatg ccaaaagcct 1854601 cccactcttc taaaaacggg atgtcatcaa agtggttttc ttgtttgcct gcttctattt 1854661 tttgttctcc ttcgtcgagc gccatgtgct ttttcatccg ttggagtttc ccttttaatg 1854721 acatatccgg cctccctcct tacgacattt gatccaacag ctgcaaaatt ctttcctttg 1854781 cttttatccc ttctatttcc gtacctatac aagacggaca gccgtcatga caaggacaat 1854841 gtgtaatcag ttgtttcgcc gcttcattaa tgtctgaaaa acgtttaaag acttcctccg 1854901 ccaaaccgat accgcccgga taatgatcat ataaaaatat ggttggcaat ccggtatggg 1854961 ctgctttaat ttgagaaaca acatgaacat catttcgatc acacatgata tacacaggga 1855021 caatatgctg cagcacattc gagatgccaa gaagcagctg ttccagtgtc ttttccccga 1855081 tgtcttcatc cgctgttttg atttcgagcc aagctgcact tgtatgcagt tcttcttccg 1855141 gcaaatgaat aggtccagac ccaatatttt caaaagtggt catttttatt tttttaaaaa 1855201 tggtcggcag ggcattgaca gtgacgtctc cgtagtgcaa tgacgtacgg cttttttctt 1855261 tcgttttatc gatttctaat accttcagct gaactgccag gtttgcatcc gtataatatt 1855321 cgacatcgac ttttctgaca tacgcctttt tatggtccca atcgagcttc tcaacttgat 1855381 actgaacgcc ttcatgcaaa taaatcgctt catcatgcaa aagcgtcatc gcactaaaac 1855441 ggtccatttc accgataatc cttacatttg caatatccga ctgatcaact ataacgacat 1855501 tttcctggga ggcggaacgc aaactgatgt ttgacgcagg gaacgactca cttgcccaat 1855561 ggtaccgttc gccgttgcgg tgaagaacag cctcttcctg aagatactca agaatatcac 1855621 tgacttccat ggctccaaat tcttcatcag ctctaaaagg aagctcataa gccgcacact 1855681 ttaagtggtc tactaaaata atcaaattct ccggattgat tcttgcagat tccggcgaac 1855741 gattaaagaa atattcagga tgccgcacaa tatattggtc aatcggtgtt gaattggcta 1855801 ccatgataat caaagattca ccgtgtcttc tgccggctcg tcccgcctgc tgccaagcac 1855861 ttgcaacact tccgggatac cccgtcatta cacacacttg cagctggccg atatcaacac 1855921 caagctctaa ggcattcgta ctgaccactc ctaaaatgtc gccttctctc agtcctcttt 1855981 cgatttctct tcgctctttc ggcagatagc ctccccgata gcctctgatt gattttgttc 1856041 caatctcttt tttcacaagc tcctgaatat ggcttaaaat aatttccacc cgaactctgc 1856101 ttctggcaaa aacaatggtc tgcactttgt ttttaaggaa ctctttcgcc agttcattca 1856161 cttctgcggt tgcgctcctt ctaatattca gcggtttgtt cacaattggc ggattgtaaa 1856221 acacaaaatg cttgcgtccg ctcggtgcgc cgttgtcatc gaccagccgc atcggtttgc 1856281 ctgtcagctg ctctcccaat tcctttgggt tggcaatcgt tgcggaagta caaataaaaa 1856341 ctggatcact tccataaaac cggcagatcc gcttcagccg ccggatcaca tttgccacat 1856401 ggctgccgaa cacacctcga tacgtatgaa gctcatcgat gacgatatac ttaaggtttt 1856461 caaacaaact gacccatttc gtatgatgcg gtagaatggc agaatgcagc atatcggggt 1856521 ttgtaatgac aatatgacct gcttttctca ccttttgtct gattgccgga gacgtatccc 1856581 cgtcatatgt aaagctttta atatcaatgc ccatttcatc aataatttca tttagctcgc 1856641 tcttttggtc ttgtgccagc gctttagtcg gaaataaata taacgcccgg tttgtttcat 1856701 cttgggcgat ggactgcagg actgggaggt tgtagcataa cgtttttcct gatgctgttg 1856761 gcgttacggt aacgatgctc tctccttttt gcacatattg aaaagcggaa tattggtgag 1856821 tatatagttc atcaatgccc cttttcgaaa gggccgcttt gattctctcg tctatacttt 1856881 cgggcatagg ccttgttttt gcttcccgag gctcaatttc atgccaattc acaacgtttt 1856941 catttccttt taaatcagaa atgagttcag tcagtgattt ctttttcatt ctttacacct 1857001 ctttgtcaag tacagtttac cgaatatttg tttgcatggc taggtgcaaa ttttatacag 1857061 ttgaataaaa aaagcaaggc atacgccctg cttatttcgc ttttattgta aagagctttg 1857121 attcgccttt acgagcagcc ttttcgcctg ccgataccat tgatcctaca gcctcaccat 1857181 tcattataac gattgggatg actgtgctgc tcgctttttc ttttattaat tccaaatcac 1857241 atgtaatcag cgggtcaccg accttcactt tatccccttc tttaatgtgg gcagtaaatc 1857301 cttctccgtt catattgact gtctccagcc cgacatgaat taacagctca attcccgagc 1857361 gagtccgaat gccaacggcg tgtttggtgt ggaaaatctg aatgacttca ccttcagcgg 1857421 gagaaacgat ttcaccgcta gaaggttcca ccgctattcc ttctcccatc attttctgtg 1857481 aaaaaacagg gtccggtaca tctgacaggt ccattactgt accgtctgcc ggagaataaa 1857541 taacctcttc tgtcaccttt tcctgaattt tgcccattcc gaataatttt ttcagcaatg 1857601 tattttctcc cttctcattc acttcaaccg ttatcccttc attcaccact atttaaccac 1857661 actttcaatt ttgcttcaat ttataacaac atctggcata gacgcataat ctggttaaaa 1857721 aaggcggtgg cgatattgga attccatgat gacaaaaaga acgaactgca aaagaaagaa 1857781 gaaatcataa cggaggcaat cgacactctt tttcaatcct cagcgttcgg caaccttata 1857841 aacggatttc agaacctaat caactcgagt ttaaaggatg tgcagacgac catacatgtc 1857901 agagaaagag atactgggct gtatatcgat attaccattc cggcgacgtt tcgagatggc 1857961 gagatcgtcg ttgatgttaa atcgaggtat ctccatgtaa cactccaaga aaaacagaaa 1858021 caccaaaatg aggctacctt tacaagcatg acaagaacgg ttcagctgcc ttatgaagtt 1858081 cgccaagaag atatggaaac gtcttggaac gagcagacaa tgacactttt ctttccaaaa 1858141 aataagcatg aatgaacgat tcattcatgc ttctatcatt taaaaaagct ggtaaatccc 1858201 tttattaaag atccgacctg attcattgca ctcattactt gacctgtcgt atccatcatt 1858261 ttattaaaat caaattgccc attggctttt ttgaactgcg acataatgct ttgaaattgt 1858321 gaaggctgct gttgattagg ccttgggata ggataagggt tagaaaatac aggcggctgc 1858381 ataggcatag gctggatcgg agcataaggc tgataataat cctgctgtcc ataatgctgc 1858441 tgaggcagtt gttgctctaa ataaccgggt gcagcctgct gataatatcc ttgcatatgc 1858501 tgaggataat aatagcccat ttgccgagga tagcttcgag agctcccgtt cattgcgatt 1858561 cccccctaaa cacaacatat ttctcttcta tatatgtatg aatgacttct attgtttgtg 1858621 tcacaagtga tgattagcat ttgtcaaatt gtgtcgaaag tttaaatttt ttaaaaacag 1858681 aaaaaagtcg aatcattatg gtaccatatt ttcaatacag atgagagggg atgcaccata 1858741 atgaacgtat catacttaag caaacgtttt gcagaaatga agaaatatga aacagactgt 1858801 atgaataaac tgatggactt tgccaagttc ctctatattc aaggacatct cagcataact 1858861 gagtttcgta acagtatgaa ggttctcgaa gcaaatggag cagaaagccc ggcatatgag 1858921 atgaattaac gtccggcccc ctataaaaac gaaaagaaga cagcctttta ccggctgtct 1858981 tctcttgcaa tttcatcctt tactgcgtgc aatgtataaa ggactgactc agtgatgtcc 1859041 ttgaatcgtt ttttatgaat atgatgaaca taagattgaa ggaccaattc caggaaatta 1859101 tcctttacgg cctcaatttg ctctttatgc acatattttg gccggcggac ttttatcaat 1859161 tcaagagcac cctctgccca gcgagcagcc agttcatcat tctcttcaac tgcaggcttt 1859221 atcgtctcaa aaaaatcata agaatgatta ctgttttttc cttcctgata ccgatcagcg 1859281 cctttttcag caacttcaat catttgctcg gtcatttcca gcaaagtttg tgatagcaat 1859341 atctttcacc tcaatgccta tcgtaccaaa tttcactcac aaattcagcc gatgcggtat 1859401 accttctcaa acgcatacct gtgttcaggc gattgataca gctcatttat acaaatatga 1859461 agatctatga tttcttcttc gagcacactt aggcgatcgt tctccgtttc ccgcatctca 1859521 gcctctaatg catttacaga atgattcagg ctttgctcag ctcgcgttaa ttcatcttct 1859581 atatcagaaa gcatacggag aatatctgtc ttgcatacat aaccggacat tcgtgtacct 1859641 ccctttcctt gtctctcccg gttaacattc tttgctctca aggctctttc cttcctcatg 1859701 acaaaactag aagcaaatcg ccaaacaaac aggtattcca cgaaaagctg aagttttcga 1859761 caaaaacacc cgcaaaaatt gtatgatcct cctcattaat gcaaacgata cttgtgagga 1859821 ggtgccgtat gaaaacaaga ccgaaaaaag ccggccagca aaaaaagact gaatcaaagg 1859881 caatcgattc tttagataaa aaattaggcg gcccgaaccg cccttctacg taagaagcaa 1859941 ggaatttcct tgcttcttta ttttttcagc cactgctcca ccgcaaaaag cgcatgaagc 1860001 tggcgctttt tatgtaaata ccagtctgtc aattcaatct gcttcggcaa ttcctcgcgc 1860061 ctaaagaacg ttttctttat ctttccatga aaccaatctg ttttcgttcc gtctaatgag 1860121 tggattaact cagggtagca tgtccttagc ataggagatg ttctttttgt aatcccgatc 1860181 atcttttcca tatcaaaacg ggaacctgtg tgcggcactg tgtgcaaaaa gtgataaaaa 1860241 gaggagaaca attctggctt gaacagcaat tgagacagct gctttcccag ccttatcctt 1860301 tcctccgcct ttgaaaagcg tttcactgaa atgccgtaaa aaaacccatt tgaggaagga 1860361 aaaataacgg tgttaaaatg aaaccagtca cttaaataaa aaggaatcgt gtcaaaaaca 1860421 ttctttttaa acgaaggatt ttgtataata ggtgtttgga tagtgttttg ttcatttata 1860481 atgagggcat acattagccg ctccgtattt cgctcatgcc aaaaacgggt ccattcttcc 1860541 gacataaatt gtgagacgcc aaacacatgc agcagatgaa acagcggttt cccaactctt 1860601 tttgaccagt ggtataaaag aagctgcgga taggcatccg aaaaaataag ccagttcgct 1860661 ctttcatagg ctaaaaagaa ccatttttgc tgtctctcac ggagtccaag ctgaaacaga 1860721 ctgcctttta agtcagtcat tgaccagccg gcattacgag aaacgaaaga agccaaaagc 1860781 gaccatttga tttccggatg acggtcgtaa aatgctttat aagcatttgt tcttgaaatg 1860841 ttatccgcgt ttttcatttt tgtctgccgc tcaatccggc tcagaagctt tctgatggcc 1860901 tgttgttctt gcacgttcat tcacttccgt catgattagt ttaataagga ggatgagaaa 1860961 gtgattcggt atcctaatgg aaaaacattt cagccgaaac attcggtttc atcccaaaac 1861021 agtcagaaaa gggccccgtc ttacagtaat cgcggaatga ccctcgaaga tgacttaaac 1861081 gaaacgaata agtattatct gacaaaccaa attgccgtta tacacaaaaa gccgacacct 1861141 gttcaaattg taaatgtcca ttatccaaaa agaagtgccg cagtgattaa agaagcttac 1861201 tttaaacaat catcgacaac agactacaat gggatttaca aagggcggta tattgatttt 1861261 gaggcgaaag aaacgaaaaa caagacctct ttccccctgc agaattttca tgaccatcaa 1861321 atcgagcata tgaagcaggt aaaggctcaa gacggtattt gttttgttat tatatccgct 1861381 ttcgaccagg tttatttttt ggaagccgat aagctgtttt atttctggga cagaaaagaa 1861441 aaaaacggca gaaaatcaat tcgaaaagat gagttggaag aaacagctta tccgatttct 1861501 cttggatacg cacccagaat tgattatatt agtattattg aacagcttta tttttcgcca 1861561 tcatctggtg cgaaaggttg attaacgaaa ggttgagatg ttatgtcaga tcaatttaac 1861621 agccgtgaag ctcgacgaaa agcgaacagc aaatcgagtc cttcaccgaa aaaaggcaag 1861681 aaacgaaaaa agggcggatt gtttaaaaag acccttttca ctttactcat tctgtttgtt 1861741 ttaggcgtag tcggcggtgc tgttacattt gccgtcatgg tttctgatgc gccgtccctt 1861801 gatgaaagca aattgaagac gccttattca tcaacgattt atgataaaaa tggaaaagag 1861861 atcgccgaag tcggcgccga aaaacggacc tacgtctcga tagatgaaat tcccgatgtt 1861921 gtaaaagaag cctttatcgc gacagaagac gctcgttttt atgagcacca cgggattgac 1861981 cctgtccgta tcggcggtgc attagttgcc aactttaaag acggcttcgg ggctgaaggc 1862041 ggaagtacga tcacccagca ggtcgtcaaa aactcccttc tttcacatca gaagacgttg 1862101 aaacggaagg tgcaggaagt atggctttcg attcagctgg agcgcaatta ctctaaagat 1862161 gaaattttag aaatgtattt aaaccggatt tatttttctc ctagagcata cggaatcgga 1862221 aaagcggcgg aagaattttt cggcgttact gatttaagca aattgactgt cgaacaggct 1862281 gcgacgcttg caggaatgcc gcagagccca acagcgtaca acccggtcaa aaacccggat 1862341 aaagcggaaa aacgacggaa catcgtactc agtctgatga aaaagcaagg atttatttct 1862401 gattctcaat ataacaaagc gaaaaaagtg gcagtgaaag acgaaggcgt cgtgtcacag 1862461 aaggaatatg aaaaagcaag tacaaacaaa tacagcgcat ttgttgaaga ggttatgaag 1862521 gaaattgatg aaaaatctga tgtcgatcca tctgctgacg gattaaagat ctatacgaca 1862581 ttagatacaa aagcacaaga taaactagat gaattaatgg acggagacac cgtcggattt 1862641 actgaaggca tgcagggcgg tgtgacgctt ctcgatacca aaaacggaga agtccgagcg 1862701 attggtgcgg gacgcaatca gcctgtcgga ggctttaact atgctactca aactaaggca 1862761 cagcctggtt cgaccataaa accgattttg gactacggac cagttattga aaataagaaa 1862821 tggtccacat acgaacaaat tgatgactca gcttatacgt attctaacgg aaaaccgatt 1862881 cgtgattggg accgcaaata tctagggcct atctcaatgc gttacgctct ggcccaatca 1862941 agaaatatac ctgctttaaa agcattccag gcagtcggta aagatactgc tgtagacttt 1863001 gcaaatggac tcgggcttgg tttaacaaaa gataatgtaa cagaggccta ttctattggc 1863061 ggtttcggtg ggaacgatgg tgtttctcct ctgacaatgg caggtgcata cagcgcgttt 1863121 ggaaataacg gaacgtataa tgaaccgcat tttgtaaaat ctatcgaatt taacgatggc 1863181 acgaagcttg acttaacacc aaaatcaaaa tcagccatga gtgattatac tgcgtttatg 1863241 attacagata tgctgaaaac agctgtgaag acaggtactg gacagcttgc acaagtacct 1863301 ggtgtagaag ttgcaggaaa aacaggaacg actaactttg atgataatga agtcaaaagg 1863361 tacaatatcg ctagcggtgg cgcccgagat tcttggttcg ttggctacac accgcaatat 1863421 acagctgccg tctggacggg aatgggagaa aacgaggctg gaaagaaatc actttcagct 1863481 gaagagcaaa aagttgcaaa gcgcatcttc gcccagctca tcgccgatgt cgatgacgga 1863541 agcggatcat ttgagaagcc tgacagcgta gtggaagcca ccgtagaaaa aggttctaat 1863601 ccggcaaaac tggcagggcc aaatacgcca agcgataaga agctcacaga gtactttgtt 1863661 aaaggcacag ctccttctac tgtttctaaa acatatgaga aagaagaaaa agaggaaaca 1863721 gctaaactgt ctggtttaaa cgtgaaatac gataaagaca atcaatcttt aacgttaagc 1863781 tggaattacg acggagatgc gacctttgct gttaagcaat ctgttgacgg cggcagctac 1863841 tcggaaattc aaaacagctc tgcaaaagag gcagttattt cgggtgtgca gccaggatct 1863901 gtatacaaat tcgaagtaac agccgtcagt gatgatggca aaagtacagc ttccacatct 1863961 tatgaggtgc caaaagctga agacgatgaa gataaaaaag accagcaaca aacggatgat 1864021 gaaaaacaag atgatgagaa gactcaggat gatacacaaa ctgatgattc tcaaaaagat 1864081 gacggtcaga cggatcaaga tcagacagat gattcaacaa acgatcaaga caaaaaacaa 1864141 gacaatacga acaccaatcc gtccgacaac aataaccaag accaatcaaa cgataatgat 1864201 aacgacaaca gtaacaacca ggatacgtcg gatggtgatt cgaactctgg taagaatgat 1864261 tcaacaggtt ctgacacgaa taaaaataaa acagacacat ctaataaaac acaaacaaac 1864321 tcatcatcca ttgaaaaaac aaattaaaca aaaaagccgt cacctttggg gtgatggctt 1864381 ttttggtaca caataaaaaa cctcccgttt taacaggagg ttttatcgat tcatcgcatg 1864441 atatttataa aaatgctttt tcatttcggt aatcagctca tcaagctgaa taaagcaatg 1864501 gtattgggtc ggcttaagaa gaataaattc cactcgttca gcccaattaa tcggctttgc 1864561 gggatatgat ttctccctca gttcttgcca atcgagcgat ttcaccggct cacctgctgt 1864621 ccaatgtaac gaagccagca aacacacaat gccctttaac atttcgtttt ggtcacatct 1864681 cgattttcgt gtttgaaaga ctgggagaag tgatgctttg atgtcatccc acacttcaaa 1864741 taaaagcgga acgtatttcc cgctgtcctc ccatggcaaa tcgccttgta attccgtgca 1864801 gaaatcaaaa tacacgggat tggtctgcaa ggttttcttc atatccgagg aactcttctg 1864861 gccaagactg cgcaagtatt gctcatagga agccaacact tcttttgctt gcgtcatcgt 1864921 ttcaccagtc cttttttatc cctcttctgc ccttctctgc acaaagaaag cagcggacac 1864981 tccgcacagc gcggagattg ggctttacag tgatatctgc cgaagaaaat aagccggtga 1865041 tgcgtaacgg accaatcttc tttgggaacc ttgcgcatca gcgtcttttc aacttccaga 1865101 accgagtcct tccaccggca aatgcccaat cgtttgctga ctctctccac atgggtatct 1865161 acggctatgg ccggcacgcc aaacgcaacg gataccacta cgtttgcggt ctttctcccg 1865221 acccctggca gtttgacaag ctcatcgcgg tctctcggca cttctccgcc gtaatcttca 1865281 ataatcattt tactcagctt ttgaatattt ttcgctttat tacgatataa accgattgat 1865341 ttaatatcct gctgaagctc ttccagcgga acagccaaat agtcttccgg ccgtttatat 1865401 ttttggaata atgttttggt cactctgttt acaagtgcat ctgtacattg cgcagataaa 1865461 gcaacagcca ccactaattc aaaaggattg gaatgaacca gttcacactc cgcatgagga 1865521 aacatgtcac ctatcttgtc taaacagaat tcaatttgtt ttagatttaa cacgattgtc 1865581 accttttcac tttattgttc aagccaattg taaaaaggaa cctgcctttt atactctttt 1865641 tgcggttcat tctgctttgc ttgtacacgc cggaattttt ggctgtgtat ttttgcctgc 1865701 tccacagttt taagcccatt tttcttccat tcaaacaaaa tccggtcaat gtagcggaaa 1865761 ctgagttttc ctgatagtac agcctctttt aacgcgtgtt tgatcagttg tgcgtcatgc 1865821 tgatcctggt cctgccagat cgccagcgtt tcacactcca aaggcgataa cggtcttgcg 1865881 aactcttcct caaaaatggt ataaaggctt ttttgttccc cttctgcttt tctttcctgt 1865941 gtttgattct gtgcaagctg aatatactcg tacagcttgc cccataaagg ctgaagagaa 1866001 tatttctcaa atttgatgcc gttttgatcc tcgcattctt caataaacag aaagcctttt 1866061 tgaataaaca tccgcaatct gtttgtacat tcttcaacag aaattgacat accttcctgc 1866121 agctgattcg gtgtaggaaa atatgatcct ttttctaaat gcattttaat ttttaacagc 1866181 agaataagtt ctgtttcatt aagcccaagc tgtttataat gcgtgagcag aagattgggg 1866241 atggttgatg ttccctgctc ctgcatatca ataaattgct gttttttcat cgtcacacct 1866301 cttactgtaa aggattgtga ttgccccttt actgtaaaaa gtctcccttg caggagactc 1866361 ttttttgttt catttgaatg tattacggat acagacggtt taacagtctt gggaacggaa 1866421 tcgtttcacg aacgtgaggc gctccgctga tccaagctac tgtccgctct aatccaaggc 1866481 cgaagccgga atgaggaact gatccatatt ttctaagttc agcataccat ttataagcgt 1866541 cagaatccag tccatgttct ttaagacgcg attccaaaag ttccatatcg tgaatccgtt 1866601 cagacccgcc gatgatttct ccatagcctt ccggcgcaat caagtcagcg caaagcacaa 1866661 cgtcctcacg gtcagaagcc ggctgcatat agaacggttt taaggacgtc ggatagcgag 1866721 tgatgaatac cggtttgtca taatgttcag caatcgctgt ttcatgaggc gctccgaaat 1866781 catctcccca ctcgatatcg tcaaagcctt tttctttcag aaattcaatc gcttcatcat 1866841 acgtaattct tgggaacggg gctttgattt gctcaagttt tgacgtgtct cttcccaatg 1866901 tgtttagttc aattttgcaa tttttaagaa ctgattgcac gatgaaagaa acgtaatttt 1866961 cctgtacttg aaggttttct tcaaattcta caaacgccat ttccggttcg atcatccaga 1867021 attcgattaa gtgacgcttt gttttagact tttccgctct gaatgtcggt ccgaaagaga 1867081 atacttttcc taaagccatt gccgcagctt ccatgtagag ctgtccgctt tgagacagat 1867141 atgcatcttc atcaaagtac tttgtcgcaa agagttctgt tgttccttca ggtgcgcttc 1867201 cagtcaaaat cggcggatcc acttttacga agccttcgtt attaaagaat tcgtaagtcg 1867261 cgcgaatgat ttcattacgg attttcatga tcgcatgctg gcgctttgaa cgcagccata 1867321 aatgtctgtg atccatcaaa aattccgttc cgtgttcttt tggtgtaatt ggataatcgg 1867381 tcgcttcgtg aatgacttca atatctgtca cagcaagttc atatccaagc ggagaacgct 1867441 cgtcctcttt gacaatccct tttatataga gcgacgtttc ctgcgtcact gatttagctg 1867501 tttggaaaat gctttcttcc acttccgctt ttactacgac accctgaata aaaccggtac 1867561 cgtcccgaag ctgtaaaaac gcaattttcc cgcttgaacg cttattagcg acccaagctc 1867621 cgatcgttac ttcctcacct acgtgcttgt acacttggtt gattgttgtt ttcaacatat 1867681 ttccctccaa aacaagaaag acattcggaa gctcattgcc ccgcgaactc ttttatcatc 1867741 actttattat acccgctctt aactaaccgg gtcaatgcag ataaaaagcg gcttttctgt 1867801 cagccgcttt ttgatctgtt agctatgttt ttctacaaaa cgcttgattc tttcaatggc 1867861 ttcttcaaga agatctaacg atgttgcata agaaagacgg acattctcag gagagccaaa 1867921 tccggatcct ggaacaatcg caactttttc ctcctcgaga agcgctttaa caaattcatc 1867981 tacatctttg aaaccgcaag attgagctgc ctcttttgca tttgggaaca agtaaaaagc 1868041 accttccggc ttcacgcagc tgaaccctgg gatttctatg agctttgcat agatcgtatt 1868101 taatctatgt tcaaatgctt ctctcatttc ttccaatggc tcagaaggcc cgttataagc 1868161 agcaatcgct ccgtattgtg cgattgatgt cgggtttgac gtgctgtggc ttgcaaggtt 1868221 cgtcatcgct ttaataatgt cttcagagcc tgccgcataa ccgattctcc agcctgtcat 1868281 gctgtgggac ttcgatacgc cgtttataat gaccgtttgc tctttcagtc tgtctgacag 1868341 ctgtgcaatg gaaacatgtt tctttccgcc gtatgtaagt ttttcataaa tttcatctga 1868401 cacaatcaag atatcatgtt caaggcacac ttcaccgagc gcagatagtt cttcttccgt 1868461 atacatgaca ccagtcgggt tgcttggaga gttaataacg attgcttttg ttttttccgt 1868521 aattgcattt ttcagctgct caggcgaaat tttgaagtga ttttcctcaa gcccttctac 1868581 ataaacaggc tttccgccag cgagtttcac ctgctccggg tagcttaccc agtaaggcgt 1868641 tggaataata acttcatctt cttcatccaa aatcacttgg aaaagggtat acagagcatg 1868701 tttggcacca gtgcagacaa taatttgaga cggtttgtat tcaatattct ggtcgcgttt 1868761 aaatttctct gcaatgctgt ttttcagttc agccaaacca ccggaaggcg tgtatttcgt 1868821 atggccctcg ttcatcgaac gcacagcggc atcaataata tgctgcggtg tattgaagtc 1868881 aggctcgcct gctcctaagc cgatgacatc atggcctgcg gctttcagtt ctttcgcttt 1868941 cgctgtgatt gccagtgtgg ttgatggtgt taatgcggat actctttttg ccagtttcaa 1869001 cttgaactcc ccctaattcg tcttaaggcg tgatattttt gagaatcttt ccagttgtaa 1869061 agtccacata acttaaactg tattgccctt ctttgtctaa gtacgtcact tcccaaagca 1869121 ggacgtttcc ttctcttgcc agatgaacct ctttttgctt tgaaaccagc ccttcatcct 1869181 ttatgatttt cgccgctttg tcttcagaga ttccctcttt cgcttctttt gagagaattt 1869241 ttgctttttt atcagcagga acccagacat ataatgcagt gcctttttta tccgttccct 1869301 ttacaacata atatttttct tttccgacaa atgtttcgac ttgatcaaca tgggcgagat 1869361 cggtttcttt tttagcttca gcagctgctg cttcgtgccc ctcttccttt tgtgccatgg 1869421 ctgatttata aatgcttgcc gagacaagaa gtactgctaa aaaaataata ccaaaaatga 1869481 cggtaaatat taatgctttt tttctcatct tctcacctac gtacgataaa tggtaaaaac 1869541 ggcttggttt ttgttttctt catccagcgc aaggccgaac atcagattgt ctcttttcag 1869601 tgtacgattc aatgtgtcca caattttata cagatcatca gaatgctcta cattaattgt 1869661 tgaaagaatt tcgattttac tttccatttt ttcatcctcc agtttgaaca aatattgtta 1869721 gtcatactcc atttcaggac acgccatact agtatcacag agcgggaaat ccgcttttaa 1869781 ataaaacacc atcctactcc cacaccgcaa aagccgcttt atgcggcttt tattcttttt 1869841 cccctgcaac ataagcttca agctcgctgt cagtcatttc ggatactgag gttgtcggca 1869901 aggcatcaag aaacagccgg ccgtaaccag cggttttaat ccgtctgtcc aatataataa 1869961 tcgttccctt gtctcccgca gaacgcagca agcgtccgat tccttgcctg aaggtcagca 1870021 cagcttccgg taatgacact gtttgaaacg gattctttcc ttttttgcgg gcaagctcac 1870081 attttgcagc atgaagcggg tgatcagggg accggaatgg gagcctcacg atcattactg 1870141 tcgtcagctc atcaccaggg aaatcaacgc cttcccaaaa atgatttgtt ccgagcagga 1870201 tcgcctgatt ggatgtttta aaagtcttca tcagtttgcc gggacttccg cctgtaatcc 1870261 cttgtgccaa gagctgaatg ccggaagcac tcatgttatg cttaagctcc tggtgaacct 1870321 ttttcagcat atcatgggat gtaaacagca caaggatttt aggctgtttt tcctttgcca 1870381 tcagttcgat ataacgggct gtatcctgta taaattcagg ttgccctgta tcctgaattg 1870441 atttcatttc ttttggaatc atcacctgca tacgctcatc gtaagaaaag ggtgactcaa 1870501 ttctcattgt ccgcgggaaa aagtcactca gtcccagtcg ttcaatcata aattgaaaag 1870561 aaccttcgac tgtaagagtt gcagatgtca gcaccacact atttttgcgc gcgaaaaact 1870621 gatcagccag aagttcacca ggttcaagag gctgtgcgta aatggccact gcatttttcg 1870681 caccctttgc atctatttca atccaaaccg cttcatcgtc atcagagcca aagaagagct 1870741 tctgcaacgt ctgacagtaa tgctgcaagc ctttcatgct tctttggtat tcatcggcta 1870801 aaaagacggt tttgctcttc atgcccttca aatgtttttc cataagggat gactgcgcct 1870861 caaaaagctg ctgcaaatgt gtcagcatgg aacaaagcct ctccgcacca tctgttaaga 1870921 tcgaccagct tttatcctgg ctttctttgt tcaccttaaa cactagacgg tttaagtctt 1870981 ctttaggttt tcttcgtttg acaaaagaat gtacagagct aaagaaagca tcactttctg 1871041 cttgaacgtg ctgaagccac tcttccaatt cgaaaaatga atcaaccggc aggctgtttc 1871101 gctggaatag ctgtctcatc ttttttagaa gtccctgctc cttcagagtg ccgattctgc 1871161 tcaatttcgt atgcaattct atgtacgtgg ctcttttccc taaatgttcg cttgccgcac 1871221 gttcaaaatg gtgtgcttca tcaataataa atgtgccgct ttcgggaagc ctttttttat 1871281 ggctgccttc atcggtcagc aaaagagaat gattggtgat caccaaatcg gaacgcatag 1871341 caatctgttt ggcccgctcg taaaaaccga tcacatgctc actgcgactt cttttatagg 1871401 agtcatcgtc ataagccaat ctgtcccaca gcaattttcc gcctgaaggc aaattcagtt 1871461 ccgctacatc tcctgtattt gtctctgtca gccaaacaag aagctgtgcc tttgtcagta 1871521 cggcatcata attatcatct tcttcatgaa gcacctgctc aaatttatac aggcataaat 1871581 aatgcgattg cccttttaaa atcgccgctg ttaccggaaa tggaaacaga tcttggacaa 1871641 tcggcaaatc ctttgtgaga atctgctgct gtaaaagcgt cgaatacgtg ctgattatga 1871701 ccggcttttt tgatttcttg gcaaaaagcg cagccggaat aagatagcca atcgtttttc 1871761 cgatgcctgg aggagcttca atcagcgcat gctcacgatt ggcaaacgca tcagccacct 1871821 ctctcatcat catcatttgg ccgtctcttt tttcataccc aggcattaac tctgacagcg 1871881 ctttttcatt tcccgcttcc cagctttcga tctcaaatga gaagttctcg tcctcattta 1871941 tacgaacatc gatagcttca ggttctctga cagaaaacga agaaaagcgc gtatagcccg 1872001 gtatctcggt atgtctgttt tcattaatga acatatccaa caaatgcgtc agatcactga 1872061 tgaaatgctg cgaaagcctt cttaactgct ttaatgtcgg ataaggaagc tgccgcagct 1872121 tttcaaggat ttccaaaaaa ataagccctg tcacttcagc atcgctgtca gcccggtgcg 1872181 gctgatcatg ccgcagctga agctcctcgc ttaattccgt cagcttatac ccttcaaatc 1872241 ccggaaaaac aatgcgtgag agctcgacag tatcaagcac ttcacaatct gggagctgaa 1872301 agcccgcctt atgtagctca tacttgacaa atccaaggtc aaaatggata ttgtgggcga 1872361 caaaataagc gccgtcaagc aattggaata cttcttcagc aactgcttca aatggctgtt 1872421 cattctcgac catttgatta gagattccag taagctgctc aataaaagca gggattgatt 1872481 tatttggatt aatgtatttt gaaaaccgct cagtaatttg tccattttcg attacaaccg 1872541 ctgcgatttg tatgatttta tcgcctttct tcggcgaatt ccctgttgtc tctacatcta 1872601 taacaacgaa ccgttgctta ttcattaaaa tggacacctc aattcttgca tacgacaaaa 1872661 gtgtaacacg ttttgtacgg aaatggagcg gcaaaaccgt tttactctca aaatcttaaa 1872721 agaaaacccc cgataaaggg ggcttttctt ctacaaaatt gtacgggctg gttcgttccc 1872781 cagcatttgt tcaattttgt tttgatcatt cagaacagcc actttcggct catggcttgc 1872841 cgcttcttga tcagacatca ttttgtagga aataataatg accttatctc cttcctgcac 1872901 aaggcgtgcg gctgcaccgt ttaagcatat gacgccgctt ccccgtttac caggaataat 1872961 atacgtttca agacgtgctc cattattatt attcacaatt tgtacttttt cattaggaag 1873021 cattcccaca gcatcaatga gatcttcatc aattgtaatg cttcccacat agttcaggtt 1873081 tgcttccgta acagttgccc tgtgaagttt gccgctcatc attgttcgat acatattata 1873141 ttctctccat ttctcgaata tcaataatga tattatctat taaacgcgct tttgaaaaag 1873201 caactgcaac agcgagaatc atctttccag caatttcatt cacaggctcg agttccggat 1873261 aggaataaag ctctacatag tctatggttc cgctagtcgt ttcaatgata tcttttgcag 1873321 cttttatcac cgcttcagga tctctttcac cggcttggac aagttccgca cttgtttgaa 1873381 gggcccgata cagcttaggc gcttcttttc tttcctcagc tgttaagtat acattgcgag 1873441 agcttttggc taagccgtct tcctctctga ccgtatcgac aggaaccaat tcaatatcca 1873501 tgaagaagtc gctgattaac ccatcaacaa cagctacctg ctgcgcatct tttaaaccga 1873561 aataggcacg agtcggcttg actagattga aaagcttcgt cagtacgatc gcgaccccgt 1873621 caaaatgtcc ttctcttgag cgcccgcata acacgtctgt gcgtctttct acatgaatcg 1873681 tgacattctt ttcaccggga tacatatcat gagcatctgg cgtaaaaaga atatcgactc 1873741 cggcgttttc tgcaagagct gcatcccgct caatatcgcg cggatatgct tcaaaatctt 1873801 cattagggcc gaattgtgca ggattcacaa aaatactcat aataacggcg tcgttttctt 1873861 gtcttgcttt gtctgctaag gttaaatgcc cctcatgcag aaaccccatc gtcggaacaa 1873921 atccgattga cttgccctct gaatggtatt gttttatggc ttctttcagc tgtgaaatat 1873981 cagtaatctg tctcatctta ttttcccccg tacaagccgt caagcactgt ctggttcatt 1874041 tgaaaggaat gcttttgttc agggaaagca cgatgtctta catcctgaac atatccgctg 1874101 attgctgttt cgatggtttc atcaatgcgc gtatattgct ttacaaattt aggtgttctc 1874161 tcaacaccgt ggccgataat atcatgataa acgagaactt gtccgtccgc tttcacacca 1874221 gccccgattc caatgaccgg tatgcttagc gtctcggcaa ttttggctgt gagttctgcc 1874281 ggcacacatt ccagcacaag catcatagct cctgcttctt cgcattttat actgtcttct 1874341 attaattttt tggcgctttg ttcgtctttg ccctgtactt tatagccgcc cagtacgccg 1874401 actgactgcg gtgtcaaacc taagtgactg actactggaa tgcctccaag cgtcaatgcg 1874461 cgaatggatt caaacacgcc ttctccgccc tcaagcttca gtgcgtcagc tccgctttcc 1874521 tgaacgatag ccgctgcatt tttcagcgta tcttccttag acaggtgata agacataaac 1874581 ggcatatctg tcacaataaa ggtattcggc gcaccccttt taacggcttt tgtatgatgg 1874641 atcatgtccg caactgtcac accgacagtt gaatcaaggc cgaggacgac cattccaagt 1874701 gaatcaccga ctaaaatcat gtcaactccc gcttgttcag caagtttagc tgccggataa 1874761 tcataagcgg tcagcatgac aatcggttct tcagactcct tcatttttag aaaatccagt 1874821 tttgttttca tgttttctcc tcctcatgtt tagaggagat gatctgccgt tttcttctgc 1874881 aagccaaaaa accttccgtt acaacgagaa ggattcttca ctttctaaag ttcggcgagt 1874941 ttcatccctc tgtcccagtc cttttttgga tcaaggcaga ctgctgcaat gtctatctat 1875001 tttaataata ggtgcagttc gcaggcgata ctgcccaatg gaagtatacc aaaatcaacg 1875061 ggcttgtacc aacacattag cccaattcga tatcggcaga atagattttt ttaatgcctt 1875121 cgttcgtttc taaaagcaga acgccttcat catctatacc taacgcctta ccgtaaaagg 1875181 ttccgtttaa cgttctggct ctcatattag tgccaatacc gagcgcatag ctttcccata 1875241 aaagcttaat cggcgtaaat ccgtgcgtca tataatcccg gtaccgtttc tcaaagcata 1875301 gtaaaatatg ctggatgacg ccggcccgat caattttttc cccagcagct tggctgaggc 1875361 ttgtcgcgat gtccttcaat tcatctggaa aatcattagg ctgctggtta acgttaatgc 1875421 cgatcccaat gatcactgaa cgtacgcggt cttcttcagc ctgcatttcc gttaggatac 1875481 cgactgtttt ttttccgtta atcaaaatat catttggcca tttaatatcc gtttggatgc 1875541 ctgctgcctc ttctattccc tgcacaacag ctactgcagc aagcagagtc agctgcggtg 1875601 ttttttggag cggaatgtca ggccgcaaaa tcaggctcat ccaaacaccg tttccttctt 1875661 gagaatgcca taccctagac attcggcccc ttccggctgt ttgtttgtca gccaccacaa 1875721 gggtgccttc cggtgcgtta ttattcgcga gctcatgagc cgttttttgc gtgcttgaaa 1875781 gaacgtcatg gtaaataaga tgctggccca tcacttccgt ttttaatcca aaacgaattt 1875841 cgctttcact gagttttccg ggttttttga tgagccgata tccttttctt ctaacggctt 1875901 ctacttcata accctctttc cgaagctctt caatatgctt ccacacagca gttcttgaac 1875961 agccgagagc atcactgatt ttttggccgg aaataaattc attgccggcc tgagaaaata 1876021 attcaataag gtcttttctt aatgttgacc gcatgtcttc agccactcct ctatgtgttt 1876081 cttttgattg gagagcttcc ctgtcacaac agcctgctcg atccactgta attcttctga 1876141 cacccatttt ccggccggcc ggtttcgaag cgcaagcaag tccttacccg tgatatcaag 1876201 atccttaagg cttttgatcg gcaggttttg ataagcgtac tgaatgtcct tcagtttctt 1876261 ttcatccagt ttttcgtttt gccgaagctg cgatattttg gccgctgaga gcagtgcttt 1876321 tttcccagct ctgtacattg tcattgcgtc aaggctctgg ccaaacgtat cggcaatgtg 1876381 aatggcttcc ttgatcactt ttcccgggag cttccaggct ttcaggaaaa ggggcgcgtc 1876441 tttcaaaact atgccaaggt taattaaaag agcagcccaa agctcctcac gggatgttaa 1876501 agagaagaat ggaaactcac tcgttgaaat caggttttct cgtttatgat aaaaaccagg 1876561 aagctcttca tacaatctcg tttgaatgag tgtttgaagc gcctggcgag aagctcttcc 1876621 ctgcagcaat ttctcaaact ctatagtttt tcgttcgact gaaacatggg agaggagtga 1876681 tttttctttc gcaatggctt cttctgtttc cggtgaaagc gtaaagccaa gctggctcat 1876741 aaagcgtacg gctctcagca tacgaagcgc atcctcttga aatctatcct caggctttcc 1876801 aacggttcga atcactttct gatcaatatc tttcttgccg ccaaaataat caagcacctt 1876861 cccgtccgct gtcatggcca tcgcattgat cgttaaatct ctgcgtttta gatcctcttc 1876921 taatgatgag ataaattgca cttctgacgg tcttctgaaa tcaacataat cagattcagt 1876981 ccggaatgtc gtgacttcat aggtttcatc ctcccagagc acaataatgg tcccgtgctc 1877041 tttgcctaca tcaacagtcc gctgaaacag ccgttctact tgatcaggtg ccgcatctgt 1877101 cgcgatatcg acatctccga tcgttcgttt catatagctg tcacgaactg cgcccccgac 1877161 aaaataagcc tgatggcccg cttcgattaa gatgcggagc acgggaagtg ctttgataaa 1877221 aactttttcc atgtgatcac tccggttctg ctaaatcggc ataaatctgt tcatactggc 1877281 tgacaatttt tttagaagaa aattcatttt caagcatctc tattgccgcc tttgtaaaac 1877341 gattgcttag ctgttcatct tctaaaatgc tcatcgcgcg ggctgttgcg gccgtaacat 1877401 caccgacatc caccaaaaat ccgctcacat tgttttttat aacctcaggg ataccgccaa 1877461 tgtttgttcc aatacaaggc actccgcaag ccatcgcttc aagcaggaca aggccaaagc 1877521 tttctttttc agatagcagc agcttcaaat cgctaataga ataaagatct tcaacacggt 1877581 cttgatttcc aagcattaag acttggtctt ccaagccata ttttctgata agctcgcagg 1877641 ctgtcgattt ctccggaccg tctccgacta aaagcagctt cgctttcgtt ttgccagcga 1877701 tattgcggaa cacacggatg acatcctgca cgcgtttaac ttttctgaag ttggacacat 1877761 ggatgacgac tttttcatct ggtaaaattc catgtttctc tttaattgcc gctgtgtttt 1877821 tcttcagata cacgcgctcg tctataaagt tataaatcgt ttcaattttt ttctccggtt 1877881 taattaaatc gtatgtttca gccgcaagcg ctgaggagac ggccgtcacc ctgtctgatg 1877941 actcaatagc aaaacggatc agatctttta gagacggatc ataacctaac accgtgatat 1878001 ccgtgccatg caaagtggta acaatgccga tattgcgttt cagcatttgt tttgcaagat 1878061 aggcgcaaac ggcatgcggg agagcatagt gagcatggat aatgtctaaa ttctcccgtt 1878121 ccgccacctc agcgattttg cttgccaatg tcaaatcata cggaggatac ttaaaaacag 1878181 catattgatt aacctcaact tcatgaaaat gaatattggg atgatatgta ttcagtctaa 1878241 acggaatgct tgatgtgatg aaatggattt catgtccctt ttcagcaagc tgcttcccca 1878301 gttctgtcgc aatgatacct gagcctccaa cgctcggata gcatgtgatt cctattttta 1878361 gttttctcat tgttcgcccc caagcacatc atgatcaagc atcagcatcc gtttggaaaa 1878421 gaaaccttcg gcatactcca cgcccgcttc tttaccgtaa agcttttctc tcgcttcaac 1878481 gatttcaata tacccattcg tcagaggagt agaaacggaa tcctttgacg ggataaactg 1878541 gcttttgtag gcgttgaggc tttgtttctt tgcctctatt gtatccgaga tatcaataac 1878601 aaaatccggc tgatgaaaac catttatcat ataatagtaa accttgctga ctttatgcgc 1878661 cggaaggctt ttttcgtctt tatatttatg gattccggcg gaaaagatcg cttcttccac 1878721 cagtgcagcc gcattgccgt gatccggatg gcgatccttt ttatacggca taaaaaccgc 1878781 ttttggccga cagattctga tgacagtgac aattgaccga attgcctgat cactcattat 1878841 taggccgcgg tctggaagcg ttagctgaat tcttttatct gcgcctaata tgcgggctgc 1878901 ttcagctgct tcttctttac gcaaactgac cgtaccgtta gaagagagtt ccgcttctgt 1878961 caaatcgcat atcattactt ttttttcctg tttgacaaac ttcgctattg tgccgcccat 1879021 tccgatctcg acatcatcac tgtgggcgcc aaaagcaaga acgtcagcat tatacattcg 1879081 gctcttctcc ccgaagaagg tcacggaatt cgaaaacacc ttcatcaagt gtgcgcacaa 1879141 gaatttccgc agtacccata tttgtggcga gcggaatgga atacacatca cataaacgga 1879201 ttaatgccga gacatccggt tcatgcggct gcgcggtcag cgggtcgcgc aaaaaaatga 1879261 caagatcgag tgcattggca gcgatcagtg caccgatttg ctggtctccc cctaaagggc 1879321 cggattgaaa acgttcaatt tgaagacctg tcgcctcatg aattttcaac cctgtggttc 1879381 cggttgcgta tagatcatga ttctttaaaa tatcccgata ggcagtcgta aattgaacca 1879441 tatcctgttt tttcttgtca tgcgcgatca aagcaatttt cattgtttat ccccccgtct 1879501 aatcaatgat attttctaaa ccatacacaa gctgatcaat cttcatgact tgttcgactg 1879561 acagtttaac gcctgacatg aaagaagcac ggttataaga atcatggcgt atctgaagcg 1879621 tttggccatc catgccgaac atgacctcct gatgcgcgat cagtcccgga agacggacgc 1879681 tgtgcaagcg aataccgttt tgctccgctc ctcttgctcc tgggagaatt tctttttcat 1879741 ccggatgtcc ttgctgcttt tctttacgga cttctgaaat catttccgct gttttaagcg 1879801 cagttccgct tggtgcgtca agcttctggt catgatgaag ctcaataatc tcaacatcct 1879861 caaaatagtt ggcagccatt tttgaaaatt tcatcatcag tatcgcaccg agcgcaaaat 1879921 ttggcgcgat gatggctccg atcccttttt cttctgttaa agatgtgagc tcttttaaat 1879981 cagcttctga gaaaccggtt gttccgacaa ctggacggac tccgtgctct aatgcaattt 1880041 ttgtatgtac ttttccgatt tcgggcgttg ttaaatcaat caagacatcc ggttgtgttt 1880101 ctgtaaaaca ggcatggata tctgtgtaaa tgaaagcatc tgactcaaca ggcatcacat 1880161 cagataattt ttgctgatcg tatgtatggt ctatggcccc tacaaggtca aaatgtggtg 1880221 ttcgttctgc caatttaaca gcttcctgcc ccattcttcc acgcggtccc gcaatgacta 1880281 atttaattgt ttcgtttgac atcttgatct cctctacttt ccttcttctt ttctggtcca 1880341 gcgatcttta tctcttgtat taaatttatg catgactcgg tcgtgagctt cctctaaaga 1880401 gatatcaaga gagttggcta aacaaaccaa tacaaatagc acatcgccta tttcctcttc 1880461 catgctttta tcatcttcag tcgctttttt tggtttttct ccataacggt gattcacttc 1880521 tctggcaagc tcgcccagtt cttcagtcag cctcgccatc atggccagcg ggctaaaata 1880581 tccttcttta aattggccta tgtaacggtc tacttcagcc tgtatgtctt tcattgtttt 1880641 atcactcact gaacgaaacc tcctatcatc ctcttacatg ttagctaatt cagatacgtt 1880701 tgacaaatgt ttaagcacgt ttgctgtttt ctttttcatc cactataata taaacgctat 1880761 ctaatggaag gaaaaggggt tttgtgtgat gcttggagaa attagattaa aaaacatatt 1880821 ttttatttta atcggagcgg caattttttc atttggcttg gttcatttca atatgcagaa 1880881 caatctggct gagggcggtt ttacaggtat tacacttttg ctttatgccc ttttccacat 1880941 cagcccctct atatcgaacc tggtgttgaa cattccgatt ttttttattg gctggcgttt 1881001 gctcggcagg acaatgtttg tttataccct tgtcggcact gtagccttgt ctttgttcct 1881061 cagcatcttt cagcgatatg aaatccatat gccccttcag cacgacttag cgctcgccgc 1881121 tttatttgcc ggcgtattca tcggagccgg actgggtatt atttttaagt tcggcggtac 1881181 gacaggcggt gttgatatca tcgcacgttt agtgaataag tattttggga ttccgatggg 1881241 cagaacgatg tttgctttcg atgcctgcgt catcattttg tctttgctta cttatctctc 1881301 ctataaagaa gcgatgtata cgctggtagc tgtatttgta gcggcaagat taatcgattt 1881361 tattcaggaa ggcggatacg ctgctaaagg cgctacgatc atctcttcga aaaacgacct 1881421 gattcagaaa aagattcttg aagaaatgga acggggcgtc accattttga aaggacaagg 1881481 ttcctacaca aaagaggata tagatgtact ttattgtgtg gtgccgaaaa atgaattggt 1881541 gatgctgaaa agcgtgatta actccattga tccccatgcc tttgtagcgg taagcgatgt 1881601 tcacgatgtg ctcggagaag gatttacgct tgatgaaaat aaaaatccgc ttccgcgctg 1881661 acatgtaata gaaaaaaggc ggctgaccgc cgcccctcat ccttatttag ggtagtccct 1881721 ttttttcagc ttgttttttt ccgccttgta ctttctgtaa ccgacatagg taagagcagt 1881781 aatgatgata ctgccggttg taatgatcac ccagagtaaa gacggatcgg catcatcctc 1881841 ctccaccctg tcaaacacat ttttcaggtc atgctgaaga agggaaagcc gttcaagctt 1881901 cgtgctctct gtcatttgct gaaattcctc ttgctcaata acatctatat gttttccgac 1881961 tgtttcaagc tgatcctctg atacatcgat tgtaagactg gggtaaatca agtcatataa 1882021 actgataaat tcattccatt tttcatgaaa gcttgtgctt ccattctttt ggacatctcg 1882081 cttcagttca gtaaaagctt ccataatcgg tttttccagt gagccccaaa gcgggtcaga 1882141 ccgattgtca accgcatcca tcagcattct gaactgcgcg gctgctctga gtttttgtgt 1882201 gtctgatgta tcagcttgct ttaaactccg aaccatatca ttatagccca atgtgatttg 1882261 acgaatttgg gctcccgtta gcatggggtc ttgctgtttt ttctcagcgg attttaatgt 1882321 tttttcaaaa tactccaaga cttgaagcgc ctcttcatat ttcgcctgtc gggtcatttg 1882381 aaagactgta tcggataaat cattcaattc ctcgaggctt ccccgctctg cagccttggc 1882441 atttccatta taaaaaataa gtgcaatcaa caaacagatc gtcagctttc gtttcatgca 1882501 ggtccctccc actctctctc cttacagaat atgaagaaag ggacaaggat agaccaacat 1882561 tgtctttaca tcagctcaag cttcgtttgc ttttttgaga ccacaagaaa gtaagcaagc 1882621 gcgattgaaa agatacttag ccaaaatgtt ccgtatccta tttcagtcat ataatcagaa 1882681 agcatagagt attgcggcat catatcaaac aagtagtcaa tgacatcgtt atgcagtgtc 1882741 cagactgcag caattgcaag atgccaaaat gaaaaacgaa aatacggact gtataatacg 1882801 ccttgaactg ccattgcaaa atgcgaagca attagcatgt agccctccca cggcaagtca 1882861 ccagttactg caagcacaag aaaattcata gccaccgccc ataggccata ctttacgagg 1882921 gtaactagcg caagcgcctc taaaagcgga gcattccgtt tcatgagaaa ggcaagcagc 1882981 acaaacagaa agaaaaacgt tgctgtcgga ctgtccggaa caaaaatcag gaaacgggcc 1883041 ggtgtctcca aaagctgcgg caagtaccaa tagtagccgt aaaccgttcc cagaaaatta 1883101 atggctaaga caagaataag catcggccgc tgccctaata catattgaaa ccatttcaca 1883161 tcgaatcaac tctcagtctg taaaaataat atgtccatat aaaaaagctg acgccgggtc 1883221 agcttttgat aataaaagta tatccttcca tttgacaatt cacaatacgt tattttgcgg 1883281 ttgtttcaga aataaatttt gcaagttctt cgagctgctt atcatttcct ttgaacacac 1883341 ccgccggcat tttgcctttc ccttctacag cgattttttt gatttcatcc ggtttcagcc 1883401 cgctgtcaac caatgaaggc ccggccgctc ctccctgaag gttatcccca tggcaagaaa 1883461 tacagccctg ttccttaaaa accttatatc cttctgcatt ggtgtcaatg tcggcttctt 1883521 ttgtaatttt cccctgttct tctgccttgg cccagtcatg agtagcaact gactgccacg 1883581 tcaaaaatac agcagcggaa atggccagaa gcatcatacc gacagcgacc ggacgcttcc 1883641 acggccttct ttctgtccct ctgtctagga atggagccaa aagcagggcc ccaaaagcga 1883701 gacctggcat aatcatggcg ccgaccactg taaagcttcc ggcggcgtat tcatacttca 1883761 acagctggta taagaaaaga aaataccaat ccggcagcgg aatataacca gtatcagtcg 1883821 ggtccgccat ccgctctaaa ggcggctgat gcacaatcgt caaaacgaga aaaccgatga 1883881 gaaagacagc tccaaccatc cattccttta acaagaaatt tggccagaaa gcctctgttt 1883941 tacccggata ctccgaataa tccttcggta tattcggctt tttttcagcc ggtatccttg 1884001 agtcgcctac aaatttcatc cctttgcccc ggtgcatgtc atcccctccc ttttattcgc 1884061 agatcaagag tttaaagcgg tcctgaaatc ccctgcttcc ggatcataat aaaatgtgca 1884121 gccatcagcc cgaacaatgc ggcaggaaga aaaaatacat ggatcgcaaa aaacctagtc 1884181 agcgtttggg cgcctacaat atccggatgc cctgcaagga gcgttttaac ttgcgttccg 1884241 atcaaaggcg tggcttcggc gatctgcagt ccgacttttg ttgcaaacag agccttcata 1884301 tcccaaggaa gcaagtagcc tgtaaagcca agaccgagca taacaaaaaa gatcagcaca 1884361 ccgacaatcc agttcagctc gcgcggtttt ttatacgcgc cttggaaaaa gaccctcagc 1884421 gtatgtaaaa acatcatcac aatgaccagg ctcgcacccc agtggtgcat ccccctgaca 1884481 atctggccga atgccacttc attttgcaaa taatataccg attcccaggc atttttgata 1884541 tcaggcacat aatacatcgt taaaaacatt ccagataata cttggataac ggttacaaaa 1884601 aacgtcagtc ccccaaagca atacacaaac gcagagaaat gatgggcggg attcacatgt 1884661 tccggtactt cgtgatcggc aatatccctc cacatcggtg taatatcaag ccgctcgtct 1884721 acccagtcat aaattttgtt cagcatgtca cccttccccc ttaggctttg cttttccaag 1884781 atacaggaag ccgtctttta cttcttgctc ataatgatca agaggcgcaa gcggcggcgt 1884841 gccagggaca ttggtgccgt ccttttcata gagtccgtaa tggcatggac aaaagaattt 1884901 attcgggttt ttaggatcac tattccagtt caccgtacac cctaaatgct tacaaattgg 1884961 cgaaagtgct acaatttcat ccccgttttt gaagacccag gctgatcttg actcttctga 1885021 ctcataccag gcatcgactt gattaatttt aaaatcaaag cgctgcggct cttttgtcaa 1885081 ctcatcaacg ctgacaacct gaaccatatc ctgcttccct gtcgatttta ataccgggtc 1885141 gagtgcgaag cgaaccatag gcatgagcat actagccgcc ataaaacctc ctacgcctgt 1885201 gagcgtataa ttcaaaaatt gacgtctgga tatatcatgt tttccgccca tctcttctcc 1885261 cccctctaag tcacccctgc aaactgacta aaatagaaaa tattgcaata actctagaca 1885321 ccctcataat atatgaatct ctcagcaagg tcaatatagc caaaatattg tttataagga 1885381 aatgtaagtg tttttataaa gtgctccata actgtaacaa aacgttcaaa atttcagcag 1885441 tgcgttcatc caatattttt ctttttaaag agtcatttaa atgctctaat ggaacagacg 1885501 atgtaacaat cattttgcct aacgcatcct cagctctcca actttcgtca gatgtgagca 1885561 ggacaacatg cggaaattcc gttatcagct cttcccgcaa atccttaagc ccttgaacgg 1885621 ttatttcatt tctatcaaca tatgtataag gcggaagtaa atatacccgt ccctttaact 1885681 gcctttcaag ttcttctgag agaagctgcg taaactcgcc tttctccgcc gccattttaa 1885741 aatggttatt aacccttatg ttaattaatg gtatgacagc ggtatcaatg taatccttag 1885801 cttgtaaata gtccttggca tcagtgattc tccacctcat cgttctcccc ctttacggca 1885861 acaagccttg caattcactg caaggctggt catattatgt gagctgattt aattggcgcg 1885921 ataattgttc aaatgcctct ttatcatgac gatctaacgc gtcgtcaatg tcttttaata 1885981 atttttctct ttggaatgtg gaaatagcgt gctctaaaat ctgttccgcc aatccctgat 1886041 cttttttatt ctcaaaaagg tttttcggaa tatgcgggtt ggactccagc accgccgcat 1886101 attcaggtga gctgtaagcc gaacggaaat taagctggat aaacaaatcc tgctgtttat 1886161 ttaatctaat atcatgaaaa gatttttccg cgtcggtagt catgacattc tctttataga 1886221 accggaacgg aacttcttca acacaatgtg ttgacattat aatgcctctc gggcaaaatt 1886281 cagcctgctc cacaaaatga accttctcca tgagagaatc atggctcatt aagtagttca 1886341 agatccaaac gcactctcgg cgctttaact gataatggtt taaaaaccaa cggataaaat 1886401 cttttttctc attgacagaa acaggggtct gcatgtaatt ccctcctcta tcgttcgtat 1886461 aatctatata cttatatgtt ccacatgaat ggttaatatt cctgcttatc tagaaaattc 1886521 atcctcgatt cgcaaaatcg tttcttcaag ctcttcattg gctccgtcca tttcaagaac 1886581 ctttttcaaa agcggcagcg cttctttttg aagaccttct tctaatagga agcttgcgta 1886641 ttcatataag aaatctctat cctcccggta atgaagatag gcagcctcaa aggattgttt 1886701 tgcttcctcg tattgctcta attcagtata tgcgcttgca agataccaat tgtatttagg 1886761 atcttcttca ccgtagcttc gaacctcttg aataagatca atgatctgat cataatcctc 1886821 ttctttgtga tacacggcaa gaagtgtatg aagcgcctcg acaaagcccg gatcaagcgc 1886881 aagcgcctcc tgaagcagct tcttcccctc ttctgacttc ccgattttca aggccatttt 1886941 ggcggcataa aggaaaagtt ctttgttata ttcatcatat ctgatcccct cttttgccgt 1887001 ttttaatgcc tcttcataca ttccttcagc ttcatagctt ttcgagagcg gcatataaag 1887061 tgaagtataa gatggatcaa gctcctttaa atcagacagc tgcttaatag ctgttttcac 1887121 aagccccgcc tgtaaggctg taaaaccata gccgaaaatc gtattaggat caggattctc 1887181 atcgacagct ttctcatacc atggaatggc atcctcaaat tcacctgagg cacttaacga 1887241 ttctgccagt ctttgatgga cattaacgcc cccgatctca ctctgctcct cagccgttgt 1887301 tttaaaatat tgaaccgctt ttgcataggc tccctgagca aagtaaagtt ctcccagtgc 1887361 aaaatcaata acaggttcat tgtccagaat ggactttgcc tggaaaagct tttgttcact 1887421 gacttcgaat aacccctgca tctgataaag atccgccata agcagcaaac tttccggata 1887481 tgatggatct gtttccggaa tagtctccag cacagcgagg gctttttctt cttcgtcaat 1887541 atctattaaa agttcagcgt agaaattcgt cagttctgtt tcatttggat ataaatcatg 1887601 tagatcacta atcagtgaaa tggctttttc tacatcgccc cactcgtaat aaagctgggc 1887661 tgcaatggct ttatcttcat catgcagctg tttttcagcc ttcgagagcg tgttgaggcc 1887721 tttttctgtt tcacctgctt caactaattt tatggcttct tgaatcaatg tattcaaatc 1887781 ggaccggtcc tttcttttcc tatacaacat caaccataca aaaaaagctt tatttgttcg 1887841 ggttaatctt atcataattc agacgaatgc ccccggcaaa taagatgctt ctgtacggaa 1887901 gggaattatt gagtcttatt agtttaccaa aagatcttga gatagaaaat gaaaaaagga 1887961 agatcgccct ctgtacagta aagcagctct ttgacctgcc ggcttgtaag taaagcacat 1888021 cccccctttt cgtttttcta tccgttctat aagacaagct atgttttttc gcctcgaatt 1888081 atgatctgca taaaaaatcc tgaagtaaaa cttcaggatt ttttcgaaag cttatttaaa 1888141 tgctcgaaga aggttggata agaaacgtga atggcatccg tgtgctcgat ttcaatcggc 1888201 tcctccgtta tacaggaagc aataccaagc atcattccga ttcgatgatc tccgtggctg 1888261 gacactgcag cgccgccttt caacgtttgt ttgccataaa ccttcattcc atctgctgtc 1888321 ggttcaattt cagcacccag cttgcgaagc tcagaaacaa cagtatcaat acggtttgtt 1888381 tctttcactt ttagctctgc cgcgtcctta ataacggtgg ttccttccgc ctgagtcgca 1888441 agaagcgcga tgatagggat ctcatcaatt aaacgcggaa tgatatctcc tccgatttca 1888501 actgccttta gagatgacgt ttctataatc aaatctccat aaggctctgc accgctatca 1888561 gcagatggtt tgatttcaag ttttgccccc atgttttgaa ggacatcaat aatacctgtc 1888621 cgagtcggat ttaaacctac gtttttcaat acaattctgc tgtttggaac catcgcgcca 1888681 gcagcaagga aaaacgcggc tgaagaaatg tctccaggaa caaaaatatc agcagctgtc 1888741 agtttctggc caccagcaat ggaaacactc gtttgatctt cagaaagctt aacgccaaaa 1888801 gcagaaagca tccgctcagt gtggtcccga gatttatggg gctctgttac agttgttgtg 1888861 ccctcagcct gtaatccggc cagcaaaaca gcagatttaa tttgcgcgct tgcaacaggt 1888921 gatacataat caattccttt taatgaagcg ccgctcactg acagcggtgt aaactctccg 1888981 ccggctctgc cgtcgatttt agcccccatt tttttcaaag gctcagtcac acgcttcatt 1889041 gggcgtttcg caatgctctc atctccggct accgcgctgt aaaaaggacg gcccgccaat 1889101 attccgagca tcaggcgaat cgttgtacct gaatttccga catctaaaag gctttctggc 1889161 tctttcaggg catcgattcc ttttccgtga atcacgacat cgctgctgct ttgctcaatg 1889221 tgaacaccca tttttctaaa gcaatcgatc gtgctcagac aatctgctcc cggcagaaag 1889281 tttttaactg ttgttgtgcc tgccgctagc gcgccaaaca taacagagcg gtgagaaatg 1889341 gatttatcac cgggaatatg tatttctcca tgtaaggtct gcaccttatc tcgtttcatt 1889401 ttttccacct caatcagcat aaaaagtttc atattccgcc cgggcttcaa tgcattgttc 1889461 tgcccttttg cggtcgtcat cagactgaaa actgatcctt aaaatcccgt taatatcctc 1889521 tcgtgtttcg ataatgcgga tattcgtgat actgatgcgc tccgcagcta agatcgctgt 1889581 tatctcggat attacacccg gatgatcggg tacatccaca tataaatcat aaaatgcagg 1889641 tatcgctccc ttctgccgaa gcggcagccc gtcgcgataa tccttggctg ttttaaaata 1889701 acgaaataga ttttccgcat cttcttgttc tacatatgta cggatcttgt caatttcacg 1889761 aatccactca tcaaaacggt ctaagatttt atctttatta tgtaataaaa tatcccgcca 1889821 cattgccggg ctgcttgatg caatccttgt aatatctctg aacccgccgg cagcaaaacg 1889881 cttaacaagc ggatacaggt tttccgaatg atgggtttgg tgaacaaggc tagctgctac 1889941 aatatgcgga aaatgactga ttacgcttgt aacgccatca tgctcctctg gcgacatttc 1890001 cacaaaatgg gcattcgtcc ccttcagcag gttttttaac tgttccacag cttgtttgtc 1890061 cgttttctgg cctggcgtta aaatataaaa tgcattttca aacaggaact ccttcgcagc 1890121 ggccactcct gatttatgtg aacccgccat cggatgccct ccgacaaatt gatagcggct 1890181 aggcagcact tgatcagcgt aatcaaccac tttttgcttt gtgcttccta catccgtaat 1890241 caaaagctca tgttcaattc ctgaatgagc cagctcttca agcataacca gtgtttgttc 1890301 aacaggtgtc gcaatgatta ctgtagctgc ctctttcaca ccgctaataa acgaatcagc 1890361 acgatcgtct atcacgccta attttaatgc cgctaccgcc tgttcatcag agatgtcgat 1890421 tccgataatc cgtttgccgg gatgattttt tttgatggct agggcaatcg aaccgcctat 1890481 caatccgaga ccggcgagca atattgtatc tttcatttga ttcatacgtc atcacctggt 1890541 ttatagacta aagaggtgat atttgatcac ctcttataaa atttcagcta aaatggcaag 1890601 tatttcttca ttttgctctt ttgttccgat cgtaatccgg agtgatgtcg ggaaacctaa 1890661 tgcgtttcct gaccggacga tatagccttt ttccagcaga gcctgaaaca gttcatcagc 1890721 aggacgttta aagtcaatta acacaaaatt tgtctgtgaa gggtagcact ttaaaccatg 1890781 agttttcgca aaatcataat actgctgaag gcctgcatta ttttgctcga cacaggaagc 1890841 aataaacgct tgatcatcaa gtgctgcaat cgccgcagcc tggcccagac ggctggtatt 1890901 aaacggctct ctcgccggct caatctggcg aatcaggttc tcgtcagcaa ttccgtatcc 1890961 gactctgagc gctgccagac cgtatgcctt tgaaaatgtg cgcaaaatca tcaaattgga 1891021 atacttgctt aagagcggca cggtttccgg gtaatcctct gctgttacat attcataata 1891081 tgcttcgtca agaacgacaa ggacacgaga aggaacgcgc tccagaaatg cgagtaattc 1891141 tccttcagat gtataagtgc cagtcggatt attcgggctg catatccaaa cgacttgtgt 1891201 ctgttcgtcg atggcttcta acatggcgtc taaatcatgt gagccgtcgg gacgaagtgc 1891261 aatttcacgt acttcagcac cttcaataac cgcattatgt ttatattgcg gaaaagtggg 1891321 ggcagcagta accgtgtttg ttttatcgtt taaaaatgcc cggcagatga tctgtatgat 1891381 ttcatcagaa ccgttgccga aaataagtga tgtttcgctg acattgaggt gcttactgag 1891441 ccttgtccgc aaagcggcgc tatacccgtc cgggtaaagg gctagctgtt gaatctcatg 1891501 atgaagcgcc tcttttgcag cctctgaaca gccgtaagga ttctcgtttg aagcaagctt 1891561 cacaacttta tccaagccat attctgattt cactgcttca atcggctttc caggctgata 1891621 aggcttcagc tgttttaaat gttctttgat acgcaaatca gtcacctcat tttaaactgt 1891681 acaagccgct aaacgccatt gcataatcct caaactcctg cagcgcctga tttctcgttt 1891741 cagcgctgat gagccggtcc tttaattctt ctatttttct gacgagcgca cttcccacta 1891801 cgacaccgtc actaatttca ttcatcttta tgacctgttc acggtttgat ataccgaacc 1891861 ctacagcaac cggaacagtg ctgagattct tcacagtacg aatgaacggg tacacggatg 1891921 aattgaactc attgcggaca ccggtcacac ccagagaaga tacacagtag acgaacccct 1891981 cggcttgttc aataatggtt ttcaaacggc tttcgcttgt cggcgcaact aaagaaatat 1892041 acgtcacctc atggctttta cattcctctt gaaggctgtt gctttcttct aatggcagat 1892101 ccggaacaag cagaccgtca atatgatttt cccgcagtaa agcgaaaaag tattctttgt 1892161 tcaattgtaa cacaggatta taatacgtaa agaggataat cggaatattc actccgtttt 1892221 ttttcatttc tccgcctaat tcgattgcct ttacgatatt cattccttga tcaagcgccc 1892281 gctttgaagc ccgctggatc accggaccgt ctgcaagcgg gtcagagtat gcaacaccaa 1892341 gctccaatgc tgtggcgcct gctttttgga gtgacttcgc cagttcaatc gaaacctcag 1892401 gaactggatc gcccgccgta ataaacggga taaacaattt ttctgatggt tgaagatcca 1892461 atttaaacat gggctttcac ctcttcttcc aatacattca ttaatgtgtt gacatccttg 1892521 tctccccggc ctgataaaca gacgagaatg agttgaccgc gatccattcc tttggcgagt 1892581 ttgaatgctt tcgctaacgc atgggcagat tcgattgccg gcaaaatccc ctctttttct 1892641 gacaaaagct ttaatgcatc caccgcttct tcatcggtta tactgtcata agtgacacgg 1892701 ccgcttttat gcaaatatgc atgctccgga ccgattccag gatagtcgag accggctgaa 1892761 atagagtagg gctcaataat ttgcccgaac tcatcctgaa tgagataagt caatgaaccg 1892821 tgaataaccc ctacggttcc tttcgaaata gtggcggcat gaagaggtgt atcaattcct 1892881 tttcctgctg cttcagcgcc gatcagttca acatcttcat ttaaaaatgc ctgaaacata 1892941 cccatcgcat tgcttcctcc gcctacacat gccactactt tatcaggcat agtgccttca 1893001 atacgtttca actgatcctt cgcttcctct ccgatcattt tttgaaattc acggaccact 1893061 tgcggataag gatgcgggcc gacaactgat ccaatcatat aaaagtgatc ctcacaatgc 1893121 tgaacccagt accggatcgc ctcatttgtg gcatccttca atgttccgtt tccgcttgtt 1893181 acaggcacta cctccgctcc aagaagcttc atgcggaaaa cgttcagaga ctggcgggca 1893241 acatcctctt cacccataaa cacagtacag gaaaagccga atttggctgc aactgttgca 1893301 gcggcaacac catgctggcc ggcaccggtt tcagcaatga ttttcgtttt gcccattttt 1893361 ttagcaagca gcgcttgacc tagcgcatta ttgattttat gagaacctgt atggtttaaa 1893421 tcttctcgtt tcaaatagat tttcgcgccg cctaagtatt cagtgactcg atcagcgtat 1893481 gttaatgcag tcgggcgtcc ggaatagtcc tttaacagct tataatactc ttcacgaaaa 1893541 gcgggatcat ccttgatttg tttaaatgct gtttgtattt catctaacgg ctgcatgagt 1893601 gtttccggaa caaactttcc gccaaaatca ccgtatctgc ctatttcatt cggatatgga 1893661 tacatatcgg ttcatccttt cttctaaaag cctcatcaga ttctgatctt tttgtccgtt 1893721 tttttcaatt ccgctggcaa ggtcaattcc ttctggctgc catttcaata ggcgtgtgat 1893781 gctatccgga ttcacgccgc cagcgataaa gcagcgttta ccaatagccg cctgctgata 1893841 ttccggcaca cattcccaag aaaatgcaac accagttccg cctctagacc cttttacaga 1893901 tgaatcaatc acaaagccgt caacattatc tttaaagcgg gctatttctt gagttgtgtt 1893961 atcttgatgg tgaagcgcct tccatatttc acagcctgtc agcttgcgaa gagcagcagc 1894021 atccgccggt ttttcatcac cgtgaagctg aatgacgtcg agcttcaagc tcttggcaat 1894081 acgtgacatc gtctctattg attcattaac aaaaacacct gcaacctgtt tttcgacacg 1894141 aacttggttc agccattttt tcacatcttc cggagatact tttcgtttgc tttcagcaaa 1894201 aataaatcct aggtaatcag cctgtgattc cgccgcaagc tgcaaatcct ttagtgaccg 1894261 aataccgcaa tattttaatg ccggtttctt cacaacctca ctccctaaac aaagcatgga 1894321 ttgctttacg ctgagaagtt tgtctcatca atgattcacc gataagtaca gctcgtgctc 1894381 catgttcttt gacaaatgtt aaatgttcta aagaaccgat tccgctttcg ctgacaagca 1894441 gtgattcttt cggagcaaga gatgcgattt gttctgtctg catgatagag gtttcaaaag 1894501 tttttaggtt tcggttgttt atgccgagaa tatcaggcgt gaatactttc aatatttgtt 1894561 ctagcgttgt tgcatcatga acctccacta acacgtccat ctccttttca cctgcttcaa 1894621 gatataattc atgaaggtgt aagggatcaa gcacttcgcc gattaacaat atggcatccg 1894681 ctccgattct tcttgattcc tccacttgaa gagaatcaat aataaaatct tttctgagta 1894741 caggtatcga aacagcgcgc tttacgtctg ataaatagct gttttcccct tgaaaaaacg 1894801 gggtgtctgt taaaacggaa agcgcatctg ctttcgcagt ttcatagtct tttgcaatcc 1894861 gcacaggtac aaaattctct ttaataagcc cttttgacgg cgacgctttc ttcacttcag 1894921 caatcaaccc gataaaccga ttcaggcttg ccagcgcctc tttaaatgaa cgtttttcga 1894981 aaggctgctc taccggcaga accagtgttt tcacttcttc tttcttttgt ttgatgattt 1895041 tttcaagcat agatctcttc ctctttctgc tttagtcgtt caagctgcgc ggcagcgcct 1895101 ccgcttgtaa tcgtctctaa cgccagctcc gttccttcct tcagtgaggc ggtaattccc 1895161 gccgtgtaaa tcgcagcacc cgcattaaaa gccgtaatag ataaagcgga actgctgctt 1895221 ttattttcaa aaatattctg aatgagataa gcgctctctt tcggagactg cacctgtaaa 1895281 tcttcaagtc tgccatttgt gaaaccgaaa tcttcgggtg aaacggtata ctcccggcgc 1895341 tctccgtcct ttaattcaat cacgtcggtc ggtgctgtaa ttgaaagctc atctaaaccg 1895401 tcacggcttg atacaaacat aacgtgcttc ggctgaaacg tctccagtgc gcttgccatc 1895461 agtccagctt tttcaacaga atagacccca atcacctgac gcttcgcctg taaaggattg 1895521 ctgagcggcc caagcagatt aaataccgtt ctgaaaccta gctcttttct agtacctgct 1895581 acatgtttca tagacgaatg gtaaagcggc gcaaaaagaa atcccatgtt gtttgtttca 1895641 atgctgcttt tgaccttttc gggagtggtt tgaatagaaa cctctagctc ctctaaaaca 1895701 tcagcgcttc cgcttttaga agagacagag cgattgccat gcttagcgat tttcgcacca 1895761 gctgccgagg caacaattgc cgaggccgtt gagatattaa aagtggaaat accgtctccc 1895821 cctgttccgc atgtatcaac aatatcagga agtccatcga ctgtaagagc gtgtgcccgc 1895881 attgccttca caaaacccgc aagctcttct ggcgtctccc cccgatgagc aagaattgac 1895941 aatatccccc ccatttcaga aggagtcatt tccgctgcca tcatcatatt catcagcgtt 1896001 tcagcctcac cggcagtaag ggtttttccg tcaacgcaca attgtagaaa tctgttcatc 1896061 agctttatcc tccttgctat gaaacatgtc ttctgcaata tgaatcgttt tcagcagcgc 1896121 accggcttta ttacagcttt cttcgtattc ggcttccgga acagaatcag caacaatgcc 1896181 agcacctgcc tgtatcgatg caacaccgtt ctttacactc atcgtgcgaa tcgtaataca 1896241 agagtcgata ttcccgtcaa acccaatgta ggcaatacac cctccgtatg tctctctcgg 1896301 tgttggctcg agttcttgca aaagctgcat ggcacggatt ttgggtgcgc ctgttaaagt 1896361 ccccgccggg aaagcagaca tcagtgcatc gacaggatga accccttttt tcaatcggcc 1896421 tgtaaccacc gagataatgt gcatgacatg tgaaaaggaa acaatttttg tgaactccgg 1896481 cacagaaaca gaaccatact ctgctactct gccgatatcg tttcgggcaa gatcaacgag 1896541 catgtaatgc tccgcttttt ctttttcatc cttcatgagc tcaaccttca gtctctcatc 1896601 ttcagctttg tctgcaccgc gttttctcgt accggcaatc ggatggattt ctaagtgccc 1896661 gtcttgaacg tgtattaacc gttccggaga gctgccgact atttctctgt ctagcagttt 1896721 catataatac atatacggcg aaggattgac gatcctaagc actcggtata actcaaaagc 1896781 atctgctttt atcggcacct caaatttttg tgataaaaca ccctggaaga tatcgcctgc 1896841 ttttatatag cttttgattt tttctacatc agccataaaa gccgattttt cataattaga 1896901 agatactgtc tcaaagctgg gtgtcttgta tgaatcagca gaaagaaaca gctcttttat 1896961 gtttttttgg tccatcattt tttcaatgag attttgaagc tccagatgat tttgatggaa 1897021 tacatccatt ttttcgtttt ttgtttcctc tccagtgagc cttgcatatt ggataaagtg 1897081 gacgtttttg gtttcatgat catacgcaat taatgtccgg caaacaaaca gcatacactt 1897141 ttccatgtct gtttctttgg tatgcgaagg aacagaaggc tcaatcagcg ggatcatatc 1897201 atagcttaag tacccgacag ctccgccgac aaaaggaatg ccaagctcag gtgttttgat 1897261 tttgtatgtg gtattcatcc agttcagcac ttcttttagt tcatttcctg tgtaaagaga 1897321 tttgctgtcc tgatcagcgg ccgaaaaacg gccctgctct tctttaattg tgagaaatgg 1897381 attcaggccg ataaacgaat atctggacca agtggatgta tcgtccttgc tttcaagaag 1897441 atacgtaatc tccctgtcaa gcttctctat catttgaatg ggtgtcagtg tatcgactgt 1897501 gaaggtctcc acaatcggta tcgtgtggtg ggacaagctg tcctctaaaa atgcggaaat 1897561 gtttgattgg aaattcattg ctctcactcc ttatggcaag gagaatgaga agatggcatg 1897621 agaggataaa atactatata acaaataaac ccaaaagaaa gacttctttt gggtagaata 1897681 aacataatgt ctcagctcaa ctaaactcat tctctgctac cctattctct aactcaactc 1897741 attctaattg ctttatacac actcttgtgt atttctaagc tgttcttatc gtattacaat 1897801 tcagtatttt ttgtcaatga taaatcgggc ctcaatacga caactttttc taaatataca 1897861 tgtctgatct gatcctgagg gacatctgtc tggaccgtca tcatgactct tatgcacttt 1897921 ttcagaccgc ctgttacgtc catttcctgc atacatgtta ccggtacata ctgccatcct 1897981 gaaagctcgc gaacagcttt tgccgggaaa acagcgtgca aatcaggtgt agccgacaga 1898041 agcatttgaa caacatcttc cggttttgta tgattttctt ctatgatttt ctctaacagc 1898101 tgtttagttt tttgtaaaat ttcttcttca gtatcccgtt caactgtagt tgctccgcga 1898161 attccgcgaa tcatcatgat gtctcctcca atcgccattt gttcagccag ctctcaagtt 1898221 catttctgga aaatgtatga tcagcaactt tccctaattc gttgagcaca ataaactgaa 1898281 tcttcccgcc acgggttttc ttatcattca tcatacggtt caagagaacc gaagtttccg 1898341 tctcttttct gatttgactt ggataaccca ggctttttag ccagctgacc aaacgttttc 1898401 tgtccatttc acagcctaca gtcttttcgc ttatatataa agcaaactgc attccgaggg 1898461 ctacggcatc accgtgagtg atctgcccat atccatattc cgcctcaacg gcatggccga 1898521 gcgtatgccc aaagtttaag taagctctta tcccctcttc tttttcatcc tgctgaacga 1898581 cagacgcttt aattgaaatg cctttaaaaa tcatgtcatt cagctgatca ttagtgatat 1898641 cacgcagtga gtggatattc agcagctcct ccagaaacgc tctgtcatag ataaaagcgt 1898701 gtttaatcac ttctgccatt ccggacctaa gctctttttc aggcagagaa cgcaggaaat 1898761 ctgtatcata gagcacggct ttcggctgat aaaacgcacc gattagattt tttccaagcg 1898821 gatggttcac ggctactttt cctccgactg cgctgtcatg cgccaagagc gtcgtaggca 1898881 tttggatgaa atcaatgccg cgcataaaag tggcagccac aaaaccggca agatccccta 1898941 caacaccgcc accgaatgcg atgatgcatg aggagcgatc catatgaaaa cgaatcgctt 1899001 cactctgcaa ttttgtgtac atgtccatgg attttgcctg ctctccactc ggtaccgtca 1899061 cttttttcac aggccatttt tcttgcagca aatggagcat ttcatcacca tacaggcggt 1899121 ccacttcttc atccgtgaca aacataatcc ttgttaaagg cctgtttaaa gaggttaata 1899181 gttcgcaagc cttttttctg ataccttgtc cgataaaaac aggatatgac gaggaagcag 1899241 tttgaacatg cagtgtcttc attaaaattc cctcgacagt tttctcatat tctccacatt 1899301 ttctctaatg cggtcaattt gatctaatcc gaattgttca acgactgcgt tcgcaatttc 1899361 ccaagcgaca gccgcttcag cgactacact tgccgcagga acagcacagc tgtctgaacg 1899421 ttcaatgctg gcagaaaacg gttctttcgt ttcaatatcg acacttttca gcggtttata 1899481 caaagtcgga atcggcttca tgactccgcg gacaacaatc ggcatccctg tcgtcatgcc 1899541 gccttccagt ccgccaagtc tgttagtagc acgggtgtat cctttttcct cgtcccaaat 1899601 gatctcgtca tggacttcgc ttccatttcg ccctgctgcc tcaaatccga tgccgaattc 1899661 cacaccttta aatgcgttaa ttgacagaac agcggcagca agcttgctat ccagcttgcg 1899721 gtcataatgg acatagctgc ccacgcctac cggcattccc tcgacaatga cttctactat 1899781 tccgccgatg gaatctccgt ttgcctttgc ttcatcaatg gcagccatca tttttttgcc 1899841 tgcctcttca tcgtagcatc tgacaggaga ctcttccgtt acacgctgca agtcttcaat 1899901 tgacgtatac tctgtttttt cagctttaac agcgccaatt tgcaacacgt ggcccgccac 1899961 cttaatgcca agctcagaaa gaatcttttt agctacagcc cctgccgcca ctctgacagt 1900021 tgtttccctt gctgaagaac gctcaagcac atttctcata tcacgatgat tatatttaat 1900081 tgcaccgttt aagtcagcgt gcccaggtct cggtctggaa atctggcgct tcatttcctt 1900141 ttcttcatct tctgtaatcg gagcggcgcc catgattttt gtccaatgct tccaatcgtt 1900201 attttcaact acgagagcaa ttggcgaacc gagtgtacgt gcatggcgca ccccgctcat 1900261 aattttggcc tggtcttttt cgatctgcat gcggcggccg cggccgtgtc ctttttggcg 1900321 tctggcaagc tcaaaattga tatcttcctc cgttatgtaa agcccggcag gtacaccctc 1900381 aataatggtt gtcagttggg ggccgtgtga ttctccggct gttaaatatc tcatgacttc 1900441 ttctcccttc atcgcattaa cgcttttaag taagactact ataacatatt tttcagcaaa 1900501 aagtcagtct atcttttttg ataaaagaat gtatcggctg ggactaggcc aaatttctcg 1900561 ggattgaaga tttgctcggt gctgccgaca aaaagaactc cattcttctt caagctatgt 1900621 gccattttta aatacagctc ttccttcgcg ctttctgtaa aataaataaa tacattgcgg 1900681 cacacgatta agtcaaagtc ttgttcataa cgatccgcca gcaaattgtg ctttttgaat 1900741 gtaatattct ttttgatttc cgttttcact tcataacttc tatttgcgtt ttgcgtaaaa 1900801 taacgatctt tcacagatag cggcacttcc tgtaaagacc gctcctgata aacgcctttt 1900861 ttcgcttttt ccaatgcttt ttcatcaata tccgtcgcta aaatctgata gcccggaaga 1900921 cctttttgct ggtccaaaag catggcaagc gtgtatggct cctcccccgt tgagcaggcg 1900981 gcactccaaa tttttaaagg cctagaggtc ttgattaacg gcagaattgc agtctcaaga 1901041 acttcccatc ttttataatt acgataaaat tctgaaacat tgatcgtcat tctgtccaat 1901101 gtttcattta agagagcttg atccttttcc aatgccgcag caaagtcctt aaagctttgg 1901161 aacccctttt tctcataaag tgacgttagc cttctcttca tttgtgcttc tttatatagt 1901221 gttaaatcga ctccggttaa ttgtttccat ttcgttgtaa atacgctgta tgtatccatc 1901281 tctactctcc cagtctcgct gtctttttgt cctagtatag cttgttttat caggaaattg 1901341 tattgtttca ataaaaaaat cagcttttca gctgatttta gatcgttggg aaaggcagag 1901401 gtctgatgca cactgccatt caacccttta ttcactttaa tgtaaacctt tacaaaacag 1901461 aacaaaaacc ggcggcgtta tatgttgccg gctctgttgc ttattttcac aatgattaat 1901521 agatccagcc tgccataagc tgctgatatg atactaattc ttcattctta aagaaaatgt 1901581 taatctcgcg ttctgcactt tcgagagaat cagagccgtg gatgatgttt tttccgacaa 1901641 acatgccata atccccacga atcgtaccag gtaaagcttc tttagggttt gttttcccga 1901701 tcagctgtct cgtcacttca atgacatttt cgccttccca caccattgcg aatacaggtc 1901761 ctgaagtaat aaactcaacg agctctccga agaaaggctt accttgatgt tcggcgtagt 1901821 gtttctcagc catttgttca gtcactctca ttaacttggc gccagctaat tgtaagccct 1901881 tacgttcgaa tctagataaa atgtccccaa tgagctgacg ttggacaccg tctggtttca 1901941 ccatgataaa agtcttttcc atcatattct ccaccccatc attatgtatg tataggcttt 1902001 cacactgcac accgaaatcg taacatcttt ctgataatta atcaatccgg ggcggagaaa 1902061 tttcttaata tctacaaaaa ttaaaatttt cttttaccga tatattttgc gatggctgca 1902121 agagacgagc gtgcgcgccc tcgaggaagc gtgtttaatt tctgaaaagc tttctgcaga 1902181 tacatttcgc ttactgccat agatgcttca attgcatctg tttttttgat ttcttcaatg 1902241 attggttcaa gctgttcctg cgttgtctca ctgttaatca atttaagctg gttttttaat 1902301 gcaggatttt tcagggcata cagcactggc aatgtgacgt ttccttgaag caaatctcct 1902361 cctacgggtt tacccagctc ttcctcagtt gaagtaaaat caagaatatc atcaataatc 1902421 tgataagaca tgccgacgta atacccaaac cagtacaatg ccttatgaat cttctcatca 1902481 gctccagacg caatggcacc aagctggcag ctgaccgcga tcaagagagc tgtttttctt 1902541 ttgatacggc ggagatacgt tctgagattt tgttccatgt tgtatttgtc tttgatctgc 1902601 tcaatttccc ctagacaaac ttcaacgatc gtctgtgaca aaatcctatg ggctttcggt 1902661 tcgttaattc tcgtcatcat ttcaagagat cccgcaagca tataatcgcc tgtgtacatc 1902721 gcaatacgat tgtcccactt tgctttgatt gtcggttttc ctcggcgaag ctctgcatca 1902781 tcaatgacat catcatgaac caaagatgcc atgtgaatca tttccagagt gacggcgaca 1902841 tatttaatct tattaatatc ataatcgcca aacatgccag aaagcagcac gaaaacaggc 1902901 cgaatacgtt tccctccggc ctgcagcagg tgaagacctg cctcgcttaa aagcgggtaa 1902961 tcggaacgta cggtttgttc aagttctctt tcgattacat caatatcgtc atttaaaaaa 1903021 gagtaggcca ttttaaattt catatcattc acccaaacat ctgtgttttc atttccatcc 1903081 gatatgcgtg gcagcgactc cgccagtaaa cgaatgatat ttaacatttt tcaggcccgc 1903141 ctcttcaaac aggcctgcca gttccttcat tccagggaaa tctctggctg attcttgaag 1903201 ccaagaatat tctttatagc tcttcgcaaa cagtttcccg aaaaacggca taatatactt 1903261 aaagtacata aagtaagcct gtctgaatcc gaacatttcc ggctgggacg tttccagaca 1903321 taccacctgc ccgcccggct tcactacacg tctcatctct ttcagtacag tcaagtaatc 1903381 agggacattg cggagtccga agccaatggt gacataatca aatgtatcat catcaaaagg 1903441 aagctccatc gcatttccgt gcagcagttc aatttggctg aatccgccgt cttttacttt 1903501 ctgctcgccg acactcagca tattttcact gaaatccaag cccttgatct cgccgctttt 1903561 gcctgccgct tttgcaagag cgatcgtcca gtcagccgtt ccgcagcaga catcaagtgc 1903621 ttttgcgcct tcctttacat tcatgatgcg catcgttttg tcgcgccatt ttttatgctg 1903681 ctgaaaactg atgacagagt tcatttggtc ataattttta tatatttttt caaatactcc 1903741 gtgtacgcgc tgttcttttg agtcctgcat aatggtttac ccttcttcca ctttctgatg 1903801 ataggtttga tcttggctga ttgtcttcag acggtttatt aaaatgttct gaataggtga 1903861 atttagaggc agaagtgact caatgctgtt tttcgctttt ttaaaacaat cttctaatat 1903921 ctcttctttt gtttttccca gctgtataaa actgccgatc acatccagaa atgcatcatt 1903981 tccgttcata agccgcttaa atacaaaaaa atcactcgac agctttttcc agcgcgggag 1904041 gttgaagtgt tccgccacac gatggaataa agctgattca acgatgccga cactttcgaa 1904101 aaaatcgttt tcgtccttga aagaacggtc atacagacga attttatgtt cgttgatttc 1904161 tttaatggct gtagcaagcg tccgaatcat gtagatatcc ttcatttcag atagtaaaga 1904221 gtagtacagc ccgctgaaat aatcgcccgc gagaacagtc aattggcggt ttttgttttc 1904281 gtctcgtttt atgactctag ctgtcgtcac ttcatcatgg gtatcaaggg cgctttgtac 1904341 aagcatcgct gttacaatat aattttctct gtcgttgttt tttatgtcgg cttcttcaaa 1904401 taaagcatga aaaagaagaa gcttatcctc atcaattttc ggcgcagaaa tatgcttcgc 1904461 taaataagga tgagacagct tttgttttaa tttcgtgttc agattggcta aagttccgta 1904521 gatgtcttgc aaaaatatca cccttgtccc caaattcaca tttatttctt aatctatgta 1904581 tgagttttat cttttcattc gcttacgcag gtatcattat agcataaaaa aaagaaattg 1904641 gctgtatcct cccgctgttt gcgagcattt gcttttaaca gcggggacag ccagcttatt 1904701 ttttttcgct tttcatttct ccgtacgcgg tttgaatcag tgcctctcct ctgactttaa 1904761 tggcagaagt atgctctgta aactgagcga tgatcacttc tcccttgtcg agtttttcgg 1904821 aatggtgaaa ctttgtgtct gttcctcttg tcaggccgat cacattcact ccgtcctcaa 1904881 cggctttaat gacgacaaaa tcacttgaat gcttttggtt catttatagc accctctatc 1904941 tttattagtc ctggcgttta atatgttcca atacttctgc acgggcagcg gcatcatctt 1905001 taaaaacgcc tctgactgct gaagtcacag ttttcgcacc cggttttctt acaccgcgca 1905061 tcgtcatgca catgtgttcc gcttcaacca ctaccattac gccatgcgga tcaagcgttt 1905121 ctacgatgct ttctgcaatt gtagaagtga tgcgttcctg aagctgcggg cgctttgcaa 1905181 cggcttcaac ggcacgtgcc agtttgctga gtcctgtgac ctttccgcct cgcgggatat 1905241 atgcaacatg tgcttttcca taaaagggaa caaggtgatg ctcacacata gaatgaaacg 1905301 ctatatcttt tacaagaaca agctcctcat ggttttcacc gaagatagtc tggaaatgtt 1905361 cttttggatc ttcattcaag ccggagaata cttcggcata catctttgcg actcttttcg 1905421 gagtatcaag aagcccttct ctattcgggt cttctccgat cgcttctaaa atttgacgaa 1905481 cagcttgttc gatttgctct ttattaactt ctttcatgtt ctatgtcctc caccaatgaa 1905541 tacatttaat ttcgattcta gcacatatgc cccgctaaaa gcaaagtgaa tgccctgtca 1905601 ggaagcccat gctcttgaaa tatgaaaagc cccttagaaa ggggcttttc tgtgaagaaa 1905661 taaagtgtat gtaagctaga tgcatacacg atctatattc acaattattt tccggcaact 1905721 gcgtctttaa gcgctttacc tggtttgaaa gcaggtactt tgcttgctgg aatttcgatt 1905781 tcttcacctg tttgaggatt gcgtccttta cgtgcagaac gttcacgcac ctcgaagtta 1905841 ccaaaaccga tcagttggat tttatcaccg tttttaagtg catctaagat cgtatcaaaa 1905901 acagagtcaa ctgcttttgt agcgtctttt ttagacaatt cgcttgcttc tgcaaccgca 1905961 ttgataagtt ctgttttgtt catgcctttc acctcctccc aaaaggatac attcagttcg 1906021 tttattatca tttcttcaca gttcagtctg attctaaacc tgtctcagaa aaaaatgaga 1906081 gcaagtaaga gaaagacaat taaacggctt tttaagaaaa actgcactct gaggaatgtt 1906141 tgtccaacaa agtgaagaat ttctgtatgt agagtaacac atataaaaag ccatatcaag 1906201 cattttaaag cgtcaatccc ttgctcgtca aggatttaag gtgatttacc gaacgaatat 1906261 tccttttttt ccttttttca tcctattcct tgatcctttt ccattattaa gagcaaagaa 1906321 aaaagacctc ccattctata aagaggtcta ccggtattac aggatgatgg cgattaagcc 1906381 gccagagcct tcgtttatga ttctttctaa tgtttctttt aatttatacc gtgcgttttc 1906441 aggcatcaat gacagctttg cctgaatccc ttctctcaca attgagctca gcgaccttcc 1906501 gaagatatcg gaattccaga tggagagcgg atcatcctca aagtcctgca ttaaatagcg 1906561 tacaagctct tcactttgtt tttccgttcc gataatcggg gcgaattcgc tttcgacatc 1906621 tactttgatc atatggatcg acggagcgac agctttcagc ctcacaccga atcgcgagcc 1906681 ctgccttata atttccggct catcgagact catatcagct aaagcaggcg ctgcaatgcc 1906741 gtatcccgtc tgtttgacca tttttaaggc atcagacact tgatcatatt ctgttttcgc 1906801 atgggcgaag tcttgcatga gctcaagcag atggtctctt cctctgattt cgacgcccac 1906861 aacttctttt aggatttgat catatagatg atcaggcgcg tacaaatcaa tttctgccac 1906921 cccttggccc agctcaattc cggctaatcc ggcactttca atgaattcaa actcgctgaa 1906981 ttggccgaca accctgtcta cgtcccggag ccgtttaata tccttaaccg tttccttcac 1907041 ggactcctga tagctttcac gcaaccaatg gttttctttc agcaccatta cccagcttgg 1907101 gagattgaca ttcacttcta gcaccggaaa ctcgtagagg gcctctctga gcacactcag 1907161 cacatctgat tcccgcatgc tctctacact cattgccaat accgggatat catatttttc 1907221 gcttaaatcc tggcgcatgg cttccgtttc cgggtgatac ggcctgactg agttgatgac 1907281 cataataaaa ggtttgccaa cctctttcag ctcttcaatg actctttctt cagcctctat 1907341 atagtcactt ctggcgatat ctccaatggt gccgtctgtc gtaatgacaa ctccgatggt 1907401 cgagtgttct tgaatgactt ttcgtgtgcc gatttcagca gcctcatgaa atgggatcgg 1907461 ttcttcgtac caaggcgtat tgatcatccg cggcccgttt tcatcttcat atcctttagc 1907521 gccgggcact gtgtaaccta cacaatctac taatcttata ttcacatcga gtccgtctga 1907581 cacatgaaca gacatcgcct gattcggaac aaatttaggc tctgtagtca taatggtttt 1907641 gccggctgcg ctctgcggca gttcatcctg cgctcgggcc cggtctgctt cgttactgat 1907701 attcgggagc accacaagct ccataaattt tttaatgaac gtggattttc ctgtacggac 1907761 agcacctacg actcctaagt atatatcgcc tcctgttcgt tcagcgatat ccttgaaaat 1907821 atcgaccttt tccaagtgat cccctcccgg acttcctatc cttttcaatt ttattaagct 1907881 ctttcaatca aacacaggac actatatgtg tatgacgttg tcctatttga atatgacatc 1907941 tttagaaaat ttctcatcct caatctatta atataaaaaa acctttctcc ctatttgtat 1908001 gcaagggaga aaggttcatt cctttttcat atcattttct aaaaaaacag gttcctgttt 1908061 gtcatttacc gtatatttta cagaaaacgc ggggacaaag ggggtttcat gccaaatcat 1908121 atcctggatt tcagtcccgg gtttaaacgt ttttttgctt tttttgaggc aagaagccag 1908181 ctcagtccgg taatcggcat atatttctcc gtctccgtca atcataagcg gcaaggaatt 1908241 ccctgagatt gggcttgtca ctgtaagaga gctgccatcc ccaagcttct tctcatcgag 1908301 tgtaaataaa tcacgagata gcacatcctt gtaaggcgga tattgatgct cctgacgata 1908361 catttggatg cgcaatttca catcgcgaat tttttctgcc atctttagat caattaattt 1908421 aacagtcgga tcgttctcta cgtcaacaag cacgtattga tagtctcccc cgctttcaaa 1908481 tgccgtactt ggaggttcag ctatgtatct tggcgctaac cggttaaagt ctatcggata 1908541 tttttgatat agcggtgtcg acatatcttt ggtttgaata ggaagcagcc ctccatttgc 1908601 cttttgaaat tcatcaacag cagattgaac ctgctttagc tggtcttgat aaggaatggc 1908661 atgcacactg cttttccgtt catttggata taaacatccg gataaaaaca cgactgccgc 1908721 aaaaatgatt gcgcacttca gtttacccat acagcacttc cttttacagc tttattcatt 1908781 gacagggccg ctaaaaacca cgacaaacac aataattcca gatatgagca tacacatgta 1908841 tgcgaatgat gaaatcgcaa tcttcaaaaa acggttttgg cacttaaagc ggcttaaata 1908901 gatggaagct acagccagaa acatcagacc catggaccct agagcaaacc acattttcat 1908961 caatgccaga ttcaatgacg tgcgcctccc cgatatgtaa gatataagcg ttatattata 1909021 ttttaatata cagcgccgga aaagatcaac cagattttcc atccattgat agaacaaaaa 1909081 aactgaagca aagaggggga ccttcgcttc agtcaacttg actatattca cctgcacgtt 1909141 taagaaacac tctcttggac ttcgatgcta tagtatgcga cttggcatac agatgcatcc 1909201 tctattgcct aaatcggcaa aatgtttcag gagatcccaa gacttgggtg ttcttctgtt 1909261 tttcgggctt tcgttcaatt aagatatgcg attcaccatt tgattgacac ttttacttca 1909321 cttgattttc aaacgtattt accaaatcct ccatctcgtg ggttttccct ctcgccatta 1909381 aagattcaac agcggtttcc actttttgtc cgttgaatag gacctgatgg agagcttctg 1909441 taatcggcat tttaacatca tatttcttcg aaagctgata agccgctttc gtcgtgcgga 1909501 cgccttcgac taccattccc atctcttcaa gaacatcttc aagcttgtac ccttttccga 1909561 gcaaattgcc cgcacgccag tttctggaat gaacacttgt gcacgtcaca atcagatcgc 1909621 ctactcctgt caatccagag aacgtcaagg gatttccgcc cattttcgtt ccgagtctcg 1909681 cgatttcggc aagtccgcgt gtaatcaaag cagctttggc attgtcaccg taccctaaac 1909741 catctgtaat tcctgcagca agggcaataa tattttttaa agcccctccg atttcaactc 1909801 cgataatgtc aggatttgtg tacacccgaa aattgtgatt aataaataga tcctgcacct 1909861 cttctgctgc cctcatgctc tttgaagatg cagtaacagt tgtggggtgc cgcagcccta 1909921 cttcttccgc atgactcggg ccggaaagga caacgatatc ttttctgaca tcactcggga 1909981 gctcaatttc cataatttca gaaatgcgca gaagtgaatc tggctcaata cccttgctga 1910041 catgaacaaa gactgccttt ttcgttataa aagggacagc ctgtctcagc acttcccgaa 1910101 ttgcttttgt cgggaccgca acgataatga catctgcgtc tgaaacagcc tctttcatat 1910161 ctgttgttcc tttaatggat gtagacagct taacattcgg caaataatct ttgttttcat 1910221 gcaactcatt aatttgatga attaaatctg cacggtgagc ccacacacac acttcatttc 1910281 cattatcagt tagaactaaa gccagtgctg ttccccaact ccccgctcca agcattgtga 1910341 cttttttcat gtttgattca caccttttta ttttctagct cttgcaaata ttttgattgg 1910401 tgtcccctca aaaccgaacg cgtctctgat tcggttttct aaaaaccgtt cgtatgaaaa 1910461 atgcatcagt tccggatcgt ttacaaacac aacgaagctt ggcggcttta ccgacacttg 1910521 agtcgcatag taaattttca aacgagaacc gttatgagtc ggtgtcggat tcattgccac 1910581 agcgtccatg atgacatcat ttaagacgtt tgtttgaact cgaagtgaat gattttcact 1910641 agctttgata atcgcaggca tcagagtatg gatccgtttt ttcgttaagg cagacataaa 1910701 taggattggc gcataatcca gaaattgaaa atgatcgcga atattttctt caaattcttt 1910761 catcgtgctc tcatctttgt caacagcatc ccatttgttt acgacgatga cgacggcctt 1910821 gcccgcttcg tgtgcataac cggcgatacg cttgtcctgt tcaataatgc cttcttcgcc 1910881 atccagcaca accgccacga cttctgagcg gtcaatcgct tttagcgccc gcagtacact 1910941 atacttctca gtcgtttcat agactttccc tttttttcgc atacctgcag tatcgacaat 1911001 gacaaactcc tgctggttgt aagtaaatga cgtatcaaca gcatctcttg tcgttccagc 1911061 cacgttgctg acaataacgc gttcttcgcc gagcatcgca ttcacaagtg aagactttcc 1911121 gacatttgga cgtccgatca gacagaattg aataacttct tcattgtatt tcgtttcagg 1911181 aatgttttta aaatgctctg caacggcatc cagtaaatca cccagtccga gtccgtgtgt 1911241 tcccgaaatt ggatacggct cgccaaagcc tagcgaataa aaatcataaa tattcgctct 1911301 catttctgtg ttatccagtt tattaaccgc taaaacaaca ggcttttttg tgcggtacaa 1911361 aattttcgcc acttcttcat cagcagctgt cacgccttca cggccgttca ccataaaaat 1911421 aatcacgtcc gcttcatcca tggcgatttc agcttgctgg cgaatctgcg ctaaaaacgg 1911481 ctcatcaccg atatcaatac cgcccgtatc aatcaaatta aaatcataat tcagccattc 1911541 agccgagctg tatatccgat cccttgtcac gccaggggta tcttctacta ttgaaattct 1911601 ttctcccgca atccggttaa agattgtgga ttttcctaca tttggtctcc cgacaatggc 1911661 tacgacaggt ttacccatag tacccttcct ttcaatccag ccgctttcat ttttacataa 1911721 attttcaacc ggttattaaa atcatttcat tcacttttat gaaaagaaac ccttcagagg 1911781 aagggcttaa ctcatttatt atatcagttt ttactgggat cacaactatt cttaaaaatg 1911841 tttcacgatc aaatacacgt catctccgat tctgtgagct attccatcaa ggatcgcctc 1911901 aagattttta gcgaaaagct ccatctcctt ttggtcattg caaaaaaaga caggtgctcc 1911961 ccctgcaacc cgatttcgat ttgtcgtgat tacagacaaa atcactttcg taagagattc 1912021 actcatccta tcaccttatc ctgattcttg ataaattcag tcggcattct aatcgcattt 1912081 tccagggttg gaacattgct aataatttga acagccgttt cgggatggtg aatttgcggg 1912141 agaacaaata ctgccactct cccatcattt aaatcccgtt ttgcaattgg tgtcaaagat 1912201 ggctctcctg aatcccgata aaccccgagc acattggaaa catcaaataa aatggcctga 1912261 cgctgcccta aatttgctat cgtcgctgct gaattaaagt ttttcggcgt caaaataaag 1912321 cccatgccat gctttaaaat cagttcctgt ttctctggaa gcccgatatt catcatataa 1912381 atattatcaa caaacagtcc cggaccgtca aagcgcggct ttatgtactc gatatctaca 1912441 atatccttca acacactgcc cgacataaac ttcatggcca gtaaaaaaca aacgacagcc 1912501 gctatgactg cagcccagat ggataaaaac acatacgcag aggttgtcaa aagcgctgta 1912561 aagatcacaa tataatttct gctttcaaac gcaatggcaa tcccctcaat atatgtgctt 1912621 ccccttgaga caagttcata cgaatccatt tgcgtcaatg tgttccgctc catgtttcgg 1912681 acatctctaa attgcgtcgc tgccaatgtt aaaaatgtga tggccgtaaa ttcctcctgc 1912741 aaaagcgccg gcataataat tgcacctaaa ccagccgcta tcaaccccag tgcgatgtga 1912801 atcactttcc catgaacata ggtcggatac tggcggtaat ccgttttcag catataaagc 1912861 cttgtcgcaa ttccggcaat gaccccagca ataatcggat agatgtaatc actcatgaca 1912921 ttttggtagc tcctttgttt gatcttttgc ttttctgacc aatctggctt gcgaggtgtt 1912981 cgtatttaga tatgccaaac agcaatatca tccccgcaga acacgcattc agccattgaa 1913041 agccgccgac agccatagcc ccggccaact tctggatcac aaatgaatac accagttcgc 1913101 cttggcacat ccctaggaca aataagacaa gctgcttctc aaaattcctt tcaacagaag 1913161 ctgttaaaag cactattaat ataacagcag cccactcagg ttttatgatg aaccaaaccg 1913221 ggtcatataa tgcaaaaaga taaacaaacg catacgcggc aacaagcgtc agatagacca 1913281 tgatgtaacg aaaacgatac attcccaaat acccggcata gacacatccg caaacgaaaa 1913341 acatcaaata tgcagcattc agggaaaaat ataaagcgat gtcatgtatg cttagaataa 1913401 tattagttaa aataaagaca gagacggcaa ttcgtctttt cgtcttttca aaaataaatg 1913461 ttgtcagaac ccacagaaac cacattgacc aatagtaata aaattgttcc attttacttc 1913521 ctccatattc ccagtatgga gttcaagcac attttttaaa caatcgatct cacattaagg 1913581 agtatgatca tgggaaaaga cagacaagag aaaaaactca aagcttcagg cagagtcgaa 1913641 tcagatcgcg accagtccat tcactatgac ggagcgacaa gccttgaaca aaacggaaga 1913701 ttcaaaaagc gaaaatcata atacaaaaag cccaaaccac atatggtttt gggcttttat 1913761 catttatcgc acactatagc ttgatgtatt gacccctctc tctgtgagcc aatgatgggt 1913821 ttcacctttg atcacaaggg gcgccttttg taaatcggca attgttctgg cacccagcac 1913881 ggtcataatc aactttaatt cctcaaggat cagctgaatc tcctcaagca gtccttcctc 1913941 accgctgtca gtcagcgctt ttaaaaaatg ccctgccatt ccggtgcaag aggcccccag 1914001 cgcaattgcc tttgccacgt caagcgcatc ttgcagaccg ccagaggcga tcatggtgct 1914061 tgcaggaaac tcagagcgga tttccgccaa acttgcagct gtcgaaatgc cccacgaatt 1914121 aaaaaaggag atttgccgct gtcttcggag attttcgatt ttcgagaaat ttgttccccc 1914181 gtaaccgcca atgtcaacag ctgcagcacc agcttcatac agctttcctg ctgatgcttt 1914241 gctcataccg aagccgactt ctttcacaat gaccggtaca ctgacccggc tgcaaatttg 1914301 ttcaatgcgt ttcaatgcgc cgctaaagct tctgtcccct tcaggcatca caatttcctg 1914361 aatcacattg aggtggatct gcagtgcgtt tgctccaatc atctcaacgg cttcctttgc 1914421 ctgagcagcc gttgcctcgc ttcccaggtt ggcaaaaatc agcccgtttg ggttttcctt 1914481 tcgaacaatt tcataggaaa gacgctctga tggatctttt aatgctgaca tttgcgatcc 1914541 cacagcaagg ggaattccag cctgagaagc cgctcgcgca agcgatttat taatctcata 1914601 tgtaagtttt ccgccgccgc cagtcattgc attgataaaa atcggcgaac tgcttgaaag 1914661 ttcgccgatt tttgtggaaa tatctacttg ttctaatgca agatcgggca gactgacgtg 1914721 aacaaacgta atatcatcaa gacctgtttc ccgcttctgg ccgatggaca aggcatgatt 1914781 gatgtgttgt ctttttcgtt ctgctcgagt cacgtttatc accaattatt ttagtttatt 1914841 cagcttatct ccgatcagat ctccaagctg gaagccagtg cttgtttctt ccttcgcttg 1914901 atattgacgg taatcttcct ggtcagcttt aggcgtttct tcaagttcac gcatgcttaa 1914961 tgaaatgcgc tcctcatttt cattcacatc aagaaccttc acttttacag tctgtccttc 1915021 ttcaaggact tcatgcggcg tgccgatgtg tttattggaa atttgagaaa tatgaacgag 1915081 accttcaaca cctggaagga tttcaacaaa ggcaccgaag cttacaagac gctgtacagt 1915141 tccttcaagc acatcgccag gcttcacttt ttcgccgatt tggttccaag gtccaggcag 1915201 tgtatctttg atcgataaag aaatacgttc attatcacgg tcaaccgata acactttcac 1915261 ttttacttct tgtccctctt caacaacgtc agacggcttc tctacatgag agtgggaaag 1915321 ctgtgaaatg tgtacaagtc cgtcgatgcc gccaatatca acaaacgcgc caaagtcagt 1915381 caggcgctgt actttgccat caagtacact tccaacttca agagactgaa gaagttcttg 1915441 ttttttattc gcttgttcac tttcaacaac agcacggtgt gaaaggatca cgcggttttt 1915501 atcacggtca agctctacaa cgagcagtga cagtgttttt cctttatagt cagtgaagtc 1915561 ttcaacgaaa tgtgcttcaa caagtgatgc cggaataaaa ccgcgaacgc cgatatcaac 1915621 gacaaggccg cctttcacga catctttcac ttcagcttca aacacttctt ttgtttcaaa 1915681 ttttttctca aggtcttccc aagcgcggtc tgcatcaaca gcacgtttag ataaaatcaa 1915741 agcatcgtct tccacttttg ttactttcag gtcaagctcg tcgtctactt taacaacatc 1915801 cgatgctttc tctacatgaa gacttgataa ttcactgatt ggaataatac cggattgttt 1915861 gacattgata atttctacat ctacatgttt gtcttctacc tttgtcacaa tccctttaac 1915921 tacatctcca acctctggca cttgaacatc aatttgattc atttcctctg tcatttgaat 1915981 aacctccttg gtccaaacct acacagctta attaaaacgg tttgaaagct gaacatataa 1916041 catgcccgct tttagccgaa tatgtattaa agaatcatcc aaaaaagttt tttgaatgat 1916101 caataaaaag ttttattagt attaacttct aataaaagga caggtttgtc aagcaataac 1916161 attctatctt cgttgaaaaa ttcaaaaaaa gtggcatttg ccatcctcag cgggactttt 1916221 gctccacagc ctcgaggatt ttatcagcta cctcttgaat ggaaagcgat gtcgtgtcga 1916281 tttcaagagc gtcttctgct ttacgcagcg gagatacttc gcgctctgaa tcaagcttgt 1916341 ctcttcttgc aatttcctca attaatgttt cgtagttgac atcaaagcct tttttcacat 1916401 tttcttcata acggcgtttc gctctctctt ccacagatgc caaaagaaag atttttactt 1916461 ctgcatttgg cagcacatgc gtcccgatgt cacgaccatc catgacgacg ccgccttttt 1916521 ccccaagctg ctgctggcgt ttcaccattt cttctctgac acttctgtgc ttggccgcaa 1916581 ttgaaacttg gttgctgatt tcatctgttc tgatcgcctc agttacatcg gtgccgttta 1916641 caaacacttt ttgtccatct tttgttgtaa tcagctcaat gtctgtccgc tttagcagct 1916701 cagccagttt ttcttcatct gtcagatcaa cgttttcctg taaagccgcg tacgtaatcg 1916761 cccgatacat cgctcctgta tcaatatata tgtacgattt tttctcagcc acaattttgg 1916821 caacggtgct tttccccgca gctgccgggc cgtcgattgc aatcgataat ttcttttcca 1916881 taattcctct ccttgctctt ttctcctcta aggattgtat cacgaacttt atgaaaaagg 1916941 gtgaaaaatt gatgaataat taatgtttga aggtttcaat cctattgttt tcctccattt 1917001 tatccacccc ttcatattga atcacttttg atacgtatgg ttcaatatgc tgatagtgaa 1917061 aaagaaattg gacaccaagt aaaatgatgg cctgaatgaa caataatttg atcagcagcc 1917121 gttcaaatgt tttcattgga gcacctccat tacaaatagt atggaagtgt ttgccgatgt 1917181 ttattccatt cgggcctttc ttctcttatt taactggcgc ctgatgcagt attgaagcaa 1917241 agcctgctgg tcacctgctg caatttctga atactctaaa gtcatttttc gtttttctga 1917301 cttggggtca ttaaagattc gtctgacaac tgcttctgtt tctatttgac gtgtgtgctc 1917361 ctcttcagga agacggatga tcaggcgcaa tgattccccc gattgaaaag aaaggccatc 1917421 agctaaaacc acggcgatgc cgcctgcact gatgttatag gatagtgtgc ggatctcttc 1917481 ttcatttccc ggctgaattt gcacatctaa taccgcatca gttcttacat attggcggcg 1917541 ctggattctt ttcatttttt cacggggagg catttcaaga cagatcattt gaagtttgtc 1917601 cttcacttta ccttttatac ggcttataaa gcgataagga acttcgtctt ttcccacaaa 1917661 ctctaccgtt acttccatat cgttatgtaa aatcacagtt cgccctgtaa ctacatcaac 1917721 aggatacgcg atcaaaagtt cattgttttc gatgctgacc gccttgcttt ttgccttttt 1917781 caattcattt tcttctatat attctaaaag tacattttct ccaatctcta tcattgactt 1917841 cactctttcg cattcaatat actcacgttt ttattaaagc acgtaatgaa aaaaaggaaa 1917901 agacatttag tcctttcctc ctgtttttat aggtctttat atataggttc tgcatttttt 1917961 agtttttcaa ccttttcttc cgatccgtct ttggcattga tatacattct gaatgtgtca 1918021 ttttcaattg tcccaagcat ttcgtagcat aacacttctt gacctagttc atttgtaatc 1918081 aaagcgagcc ttgtttctct cacttgtaca tttttattta atttagactt tgcctctgct 1918141 tcagtaattg caggcttagg tatggttctt tttctgtgag atgtgaggaa gtctcttgct 1918201 gaaaagccga caacctcacc gtcatccaag gccactttca tacgaattgc ctcggggtac 1918261 atccggactt tattttcaac aggaacatat gaaaatacac cgattttatc atattgggca 1918321 ctttcatcaa tttccaaatc atctgtttca aatccgtttt tctttaaaaa tgcaagcgct 1918381 cggttcgatc cgtcatttaa actgattttc tgatctttca cttctctgtt ttggatcaag 1918441 tataccggat gcccgccctt cttcgtaata tccatataaa tcactgcttt atggtctggg 1918501 tctttcatgc tgatgctata tacatcgcga tttgtttttt ttccgctctt taccacttta 1918561 attgaataat tgtcatctgg ggcaaagcgc tcagcaattt gttttgcttc ctgttcggaa 1918621 atttgttttc ccttcagatg gctgaagcct ttctcttctt ttttcgtact ggtgaaactc 1918681 gggccaagat cagtgccagt ggagaatgca ccaacatttt tttcgactgt tttaaagctg 1918741 ttgataatcg tattatcact ttgtttttcg tcagaagcca gagccatttc tacgtccatc 1918801 cagcgaaggt ttttgctcat gacaaggtgc tgaacatgac gcaattcatt ttgtatatct 1918861 tcggactgct gatatagctt atttagtgat gtatactcgt ttttatcaag cggcttttgg 1918921 tccaaatctc tgactgacgt tttatagctg aaatcgccga tctttgataa tagctcttca 1918981 gttttattaa acggcattaa tgtaagcggc agctgactga cgctgttatg agcttctgat 1919041 gtaatcctcc acacatcgat caatgcaggc gacagtgatt tttggctgtt catggcaagt 1919101 gttgttccga ttttatcatg aagctgatcc acctgatagg taagctcatg aaacgcccgc 1919161 tgatagttat tttcagcatg aagaagaact gcgtcttttt cctggtgttc tttgtatccc 1919221 cagtagcctg taccgactat tgcaatacca agcacggcga ttaaaattcc tctgatcatt 1919281 tatcacacct ctttttatgc tttctcatat ctgctactca cagaaaatgt gtttaccgat 1919341 tcttttaatc tgcggacgcc cccaaatcca cggacttgta gccgtatccg gattaaagta 1919401 gtaaagtgct tcctctgatg ggtcccagcc attgatggca tccagcactg cttctcgtgc 1919461 cgtttcattc ggctgcatgt aaatttgtcc gtcggctact gctgtgaagg caagcggctc 1919521 aaaaataacc cccgctactg aatttggaaa taacgggctg ttcaaacggt ttaaaatgac 1919581 tgctgcaata gcaacctgcc cctcgtacgg ctcgccccgg gcttcgccat aaaccgcttg 1919641 agcaagcagc ctgatatcgt tgttggaaaa tccaccaggc atgttcgctg ctaccgcatc 1919701 ctgttttctt gcttttgctg gtgtattgtt ttgctgttta ttcgcattcg ctttaggctt 1919761 ctgcgttgtt ttttccgcag gctgtttctg ccgtgcttct gcttgttgtc ttgccttttg 1919821 tgttgctgct tttgatggtt tcgtctgata ctttagcgga atttttccgt aatgcgtgaa 1919881 tgtattccct ttattgagct gttccatgac atattcacga tagtattttg atttacatat 1919941 taaggtttgc tttgttttag ctcctacaag gccgtcaacc tcttttaacc cgaattgatc 1920001 ctgaaaattt cgaactgccc agtacgtccc ccatccataa accccgtcaa tttttccgtt 1920061 ataatatccg ttgtattgaa gacgcgcctg aagctcgacc acatcatccc ctgttgcccc 1920121 tctttgaatg acctgattcg aaaaggcaga gatcgtttca gtattaataa acgtcgttat 1920181 tgtaaaggaa aaaaggatga gacatgccat aatcgatcct ttggacttca tcttttcaag 1920241 cctcctactg caaattttta agtgtaatcg tattttctgt aacgaggtta tttttataca 1920301 ctctttcctt gttatccctc agaacataaa aactgcacac aaaaaagccg cacggttgct 1920361 gtgcggcttc tatacttgca tcatattaac ggaacgggct tttttcgctt tacgcaaacc 1920421 aaaccaccat aaaaatacca taaatggaag catataataa atccaattgc taagcgctgt 1920481 taggataaaa tcatatgatc catgcaaaag ggatgggaca actaaagaaa gagtaagcca 1920541 ctttacacgc gccttatcag cggaaaaacg ggcttttcca aggtaaaatc ccattataac 1920601 gccaatcaag gcatggcatg aaacaggcag cagcgccctg acaaacgcat gctccacgcc 1920661 gtggccaatt aaataaagaa tattttcgag ggttgcaaaa ccgagtgata cacttgcacc 1920721 gtacacaatc ccgtcataat gctcatcaaa gtgggcgtgc gggtaaacac tgatcatcag 1920781 tataaaccat tttaatgatt cctccaaaaa ccccgaagat aaaaaagaaa cgaaaaagct 1920841 tccgcctcct acattctctt tttcaagtac atactggata aacatgatgg gaaatacaag 1920901 aacaaccccg agaaaaaacg accgtagcac catatgtaca ggttcattat catactgatc 1920961 ttttaaataa aaataactta ataacgcgat gccgggggca attcctgcag agatgattgc 1921021 aaacatcagg caacctcttt cctttatatt cctacatcta tcctaccatg ttgtttaaaa 1921081 ttttacatct gtctgcactt aaaaaaacaa aaagagcata cgaatgcatc atatgctcct 1921141 catctttaat ggttttctct tttggcgatt tccgctgcga tatgcccccc gtgaaacctg 1921201 ccgttttcaa taaatatttc atttgcattg tttcccgcag caataacacc ggcaataaag 1921261 acaccttcaa cgttcgtttc catcgtttct tcgttgaaaa atggacgccc tgtttcttta 1921321 tcaatttcaa caccaatttt ttcaagaaat tgatgatcgg gatgatagcc tgtcatggca 1921381 aatacaaaat catttttaat ggtaatgagt tctttctctc cggagcgaaa cacaacttca 1921441 ttctcggtga ttttttcgac acaagctcca aattccatac ggattgtacc gtttctgacg 1921501 agagcttcaa attccggcag aatccacggc ttaatgctcg gagaatactc attgccccta 1921561 tataaaactg tgacacgcgc cccagatttc acgagttcaa gggcggcgtc cacgcttgaa 1921621 tttttcccgc cgatgacaac aacatcttta tcaaaatacg ggtggccttc tttaaaataa 1921681 tgaaatactt tcggcaaatc ctcaccgggt acgcccatat agtttggatg atcataatag 1921741 cctgtggcga tgatacaata tggcgtcgtg taggtctctt ttgacgtctc aataacgaat 1921801 gtgttatttt gcgttttcgt cactttacgc accatttcaa acgcattaac acggatgttt 1921861 ttccgtttaa cgacttcccg gtaatacgat aaagcctgaa ttctgacagg cttcctgttc 1921921 tctgtaataa atgccacatc tccgatttcg agcttttcac ttgaactgaa aaaggtttga 1921981 tgcgtcgggt aattgtaaat actgttaacg acattgcctt tttcgatgac gagggcatca 1922041 atgccaattt gttttaggtg aatggcagca gatagtccac aaggtcctcc gcctataata 1922101 attgcttttt cttgaatcat ttctgtcaac tcctgcgatt ggcatttcac ttcatatttt 1922161 ctatttccga ataaaaaaat ctcctatttt atcataggag attttttatt tttatgcaaa 1922221 tcatcaactt atatccagcc tctaaaacgc gaagcttcag ccattttgcg aacgccgacc 1922281 atatatgcag cgagcctcat gtcaattctt cggttgttag ccatttcgta aatattgtta 1922341 aatgatttga ccatcatttt ttctaatttt tcttctacct cttcttcact ccagtagaag 1922401 ccttggttat tctgaaccca ttcaaaataa gaaactgtta cgccaccggc acttgccagc 1922461 acgtctggta caagcagaat gtcccggtct gaaagaattt ttgttccttc aagcgttgtt 1922521 ggtccgttcg ctgcttcaac gacaatttta gcccggatat tatgggcatt ttcttctgta 1922581 atttgatttt caatcgcagc aggaacgaga atatcacaat ccagctccag cagctcttgg 1922641 ttggtaatgg tatcgttgaa aagctttgtt acggtaccga agctgtcgcg tcggtcgagt 1922701 aaataatcga tatcaaggcc ttccggatca taaagtccgc catacgcatc tgagatgccg 1922761 acaacttttg cccccgcatc atgcataaat tttgccaaat agcttcccgc gtttccgaag 1922821 ccttggacaa cgacacgcgc acctttaata tcgatgcctc tcttcttagc cgcttcttta 1922881 atacagatgg taacaccttt tgctgtcgca gattctctcc cgtgagatcc gccaagcaca 1922941 agcggtttgc ctgtaataaa tccaggcgaa ttaaattcat caattcttga atactcatcc 1923001 atcatccaag ccatgatttg tgagtttgta aatacatccg gtgccggcac gtcttttgtc 1923061 gggccgacaa tttggctgat cgctctgaca taccctctgc tcagacgctc cagctctcta 1923121 aacgacatat cccttggatc acaaacaatt ccgcctttac caccgccata tggaagatca 1923181 attatgccgc attttaaact catccaaatt gaaagcgcct tcaccgcctt cacctctttt 1923241 tctgttacgt tcgggtgaaa acgtatcccg cctttcgttg gaccgacaga gtcattgtgc 1923301 tgcgcacgat atcctgtgaa aatctttact gaaccgtcgt ccatacgaac aggtattttt 1923361 accgttaata atctcatcgg ctcttttaac aattcgtata cctcttcggg atatcccaat 1923421 ttttccagag ccttatgtat tacggtttgg gttgatttta atacatcaag tttgtcctct 1923481 tctgtatgac cggtgtttcg atcggctgcc atttgagtta acctcctaga atcttctgtt 1923541 tctcacatgc tccctttcag agaatagtat acaccttcat atgatctgtg catagaataa 1923601 acgttatgtt tttccatgtt ttttaacgaa aaaaaactgc tgaaatcagc agttttccgt 1923661 tgcattctta tgaaaaatga gtttgtatcg tttctacggc attaccgtcc ataatgagct 1923721 taccatactc ttgcaggcga taaatcgtta aagttgtcgg attgccgtat tcagccagaa 1923781 ccgccacaac cccttcagcc gtatgtgacc ctagatcttc aaggcttaaa aagtactgcc 1923841 cgtcatagtg gtagacagtt ccccctgtga taccgattcg ctgtaagctt tctgaaagct 1923901 gaatgatatc ttcaaaggaa tggaattgat atatgatgtc cgcgctttca tcaagcttga 1923961 cttgcatttc gatgtaatca tcatcatact catcgtcttc tgaatcggcg tcttggttct 1924021 ttgttacaat cacgaccatc ccttgtgctt ggagagaata cacttccact gcaatcggtc 1924081 cattcgcttc aaagccgagc tctgtatttg cttcattcat catatcttta aataactggt 1924141 ggactttaaa tgagtccttc cagaggtctt cttttgtcaa tccccggtct gtcaaatcat 1924201 cgagggttaa aaagattttg atcttattat aattcagacg ctcaagccgc ataacgttcc 1924261 ctcctgcctc tacttgcaca caaatcatat aacacattat atgagatgat gagtcatagg 1924321 ttcttaattg ttatcagttt acactgagtt cactagtaag acaagcacaa tgcagttttt 1924381 attgccatac ggatttttgc tttttagaag ttattctggc ccgcaaagag tcacaatgtg 1924441 agtttcaggc tcagcaccta aacgaagagg cacttttgtc gtgccgtagc cgttgctgat 1924501 cagatatgcc gcgtttttaa caatacctgt tttccccagt tcataaggac cgaattttcc 1924561 aaacctgatc tggcctccat gggtatgtcc gctgagtatc acatcaatac cgtcatcttc 1924621 attgatttgt tcatgaatct ccggattatg gcaaaccaga atattcagct ggctttcatc 1924681 aagttctttg atggcttcct cataatgatc catctccatc ctgatatcat caacccccgc 1924741 aatcgcaatc gtatgcccat tgtatgaaaa cgggactgac tcatttctca gagtgatgac 1924801 gccgtgcgct ttaaatatgg aatacagctt atgctgcctg acttcataat cattattccc 1924861 ccacacaaac acgataggga ccccgaaatg tacgagcctt ttgatgtttt cctcgattct 1924921 cgcactgggc accccgccct cagctaaatc accgccgatt ataaccaagt ggggggcatg 1924981 gcttcgcgct ttttctaaaa ggtcttgatc gatgagacgt ttgtgaatgt ctgaaataaa 1925041 aaagattgtc agaggcggct tgcccttcat ctttgataaa ggaaacgtat gtgtcttcaa 1925101 atgattgcct tttgctgttg catacatttt tgccgtcatt gccgctgccg caacagttag 1925161 tacaccggca attttcactg atagcttcat aaaaaactct ccattctttt tagaacttat 1925221 caataagacg gacaataaaa aaagacgttt ctatcgtttg agaaaacgcc ccattttatt 1925281 tactttcaaa atatagatta atgtcatatt tgtgcttcat catatgaaaa acagactctc 1925341 tcgccttcca tttatcgggc tgcggccaga gatcagtgct tttctgaata atttcacatc 1925401 tcagtttatg gaaatcagtc tcggattttt cttccttttt cttgaaataa tatgaagtgc 1925461 agtaggcaaa agcggttgcc agcatccaaa ataaataaaa ggtatggcta agtatttctt 1925521 gaagtataag ctgaggctcc gggcttttga tcatgatcat aacacataat aagcctaggc 1925581 agataagtga agcccatcgc catctgcggc attgtgctgc ataattttcg aatttttgtt 1925641 ttcgttttac cagcgcttgg agcatctgtt tggtcggcgc gtctgtaaac tgatccagct 1925701 gattccataa ggattccata cgcttcacac cttgtccatt ttcattgcta caatatatga 1925761 acgtaaaata aaaataatac cctattcatc cattaaaggg atgtccaaaa cttgtccggt 1925821 gtaaacatca tttccattca gatgattata tgctcgaatt ttttcttctc ctgtccggct 1925881 tttataatac ttcatggaaa tgcggtatag cgtttctttc ttttggacgg tgtgcttgac 1925941 aacgcgattc ggcacatttt gaactggctc agctggctgt tcttgctgtt gtactgttga 1926001 ttgggaagag gaagcagccg cggcggttgc ttcctcctta tttggcgagt cttctttttc 1926061 cgctacagca gtctgtttct tatcagcagc tgtttgctct tttggcttgg aatcttctgg 1926121 ctcttttttt gactccttct gcagtgcggt ttctttagtg tctgcggtat cgtttttatc 1926181 ctctgatttc gggacaacct catatttgct ttggctgctg tcaataaaaa catcttcata 1926241 atcgtcatga ttatccgggt ggctctttag ataaaataag gtgactaaaa cgataaccgg 1926301 cacaaataca aatattactg cgagtactgt gaataatggc gtttttgttt tgccttgctt 1926361 ttttttctgt tctctttgat tttttacaga ttgtcttgtc ggaaggcttt ctccatcatc 1926421 gacataatcg tccgccaatg cggcgttttg atcttcataa agattctggg cttttcttct 1926481 ctctactctc gacatgttcg tcatgtttat ccctcctcac atgttcaaaa cgaatctgac 1926541 aggcaaacac ggcatcaatg ataaaatgcg ccgtcatcgg aacaaataag ttgccggtcc 1926601 attcatacat cagaccgagc aaaaagctga ttgctgtcac cataataaat aacagccatt 1926661 ttgacaaata ccgaaagtgc agagcggcaa atataaggct ggccgtccat aaaccgatat 1926721 gagtctgcag cactcctctg aataacattt cttccgcgaa agcaatcaga agcgttaaaa 1926781 atataatatg agggattgac ctcttactga atattttttt attgattccg ccgtcatcat 1926841 ataaatgaga cggaaaccat ttcattactg ccatatcggc taaaataaca ataacagcta 1926901 tagaaacacc ataccagatg attcgcatat cgcgaatgtc ccagagcttt aatacgtccc 1926961 gtacatcctc aaaaaagaac agtcctgctg cagcagcggc aaagatgatg agtagctgcg 1927021 tcaaatataa ctgcttcagc atatcatggt cagtcatatg ctgaatataa tctttttgct 1927081 gtttcagttc agctcaccta cagtctgcaa gctgaatatc cggtgcaatt ccgaactcca 1927141 gctgtctaat ggcgccattt tactccgttc ccctttttgt tcatacaagg ataaatcaaa 1927201 accgcaatgt gaacagcacg ggaggtttcc gtcatcaggc tcgtatgatt catcaaagta 1927261 ggttaacagt gcctgcctta aacagccgtc acgctgaagc aaaaatgata cacggtgcat 1927321 tttttccagc ttcagctcca tgcgatatga aatttctttc ttcatcagtt caactgatgt 1927381 ttttccctgc ataaagagat gaatcatcat acgggcctgt gtctctccga cgccatactg 1927441 aagtaatacg tcacgcagcc ttctctcatc ccgctcctcc gtcttctcta gcacacggat 1927501 tacgtcggcg atttcttcag ctgtgacact ctccatctgg ataatttgtt cctgcaattc 1927561 aaaatcccct ggcgcccgca gcaaaatgct gacactcggc tttccgtcgc gtcccgctct 1927621 gccgatttcc tgcataaaag cttctgccgt ctgcgggaga tgaaaatgaa tcacatatct 1927681 gatatcaggt ttatcgacac ccattccaaa cgcattcgta caacatatca catcaagctg 1927741 gttatgaata aactgctgct gaattaaaat cctgtcccct gactccaaac cgccatggta 1927801 aaagtcggct ctgctgctcg ttttgctttt aatttcaccc gctaattcct tagcccattt 1927861 ccgtgttgga caataaacaa ttcccggacc ttgcaggttt tcaaccagct gaatgaccct 1927921 atctattttt tcggcagtat ccgccgcatt ttcaaccctc agtgcgatgt ttgggcggtt 1927981 gactgagttg agatggcgta cagcatgctg cagctccagc aggttcatga catcttgcag 1928041 cgtttccttt gtagccgtgg cggtcaatgc cagaacgggt gggtgtccaa gtttttttct 1928101 cagctgtccg agctttgaat aatcaggcct gaagtcgtgt ccccattcag aaatacaatg 1928161 cgcttcgtca ataacaaata ggctaatcgg aacgcttttc aatttttcca atacatatgg 1928221 agactgtaaa gcttcaggag acaagtacaa aaatttatat cgatgaatat gttctaaaac 1928281 aaattgtctt tcctgcctgt taagcatgct gttcaaagct gcagcacgct tttccccccg 1928341 ggctttgagc tgctgcacct gatcctccat taaagaaagc agtggagaaa cgattaatac 1928401 catgccatca agcatataac caggcagctg gtagcaaagc gatttccctc ccccagtcgg 1928461 gagcattgca atggtatcct tcccgctgag tatgctttca ataatgtcct gctgcccttt 1928521 tttaaaggaa gtaaaaccaa aaaactgata taacgtttgc tgtaatttag tcatattgct 1928581 gcacctgctt tgtcaatgcc agtctgattt gaaagtagct gaaccgctgt tccagcccgt 1928641 cgcgaatttg tttgatttta ttcgtccgca tccgtttggc aaactctgcg atttgaagct 1928701 ggtcttctgc tgatacatag tcattaatca taaacgcagg ctcatggaga gaaatctcga 1928761 caatgtggtc ttcaatcgtc gctgttttca gctttctgat ttcagcaatt cgctgtatcg 1928821 gaaacccttg tttgaccatc tgccatgttt tcctcgtcga ctctgtcagg gcattatcta 1928881 agtgcacatc agaaaggaga tcctttaaca aagcatcttc acactccgga agagaatgaa 1928941 taaaataatg taccgaagcc caaaacatga tatagacata ccattcgtct tctttcagcg 1929001 tatcagcaag ctgcctgctc gtataaccga tccgatggtg cgaggttaag gagtagacaa 1929061 aaatttgcgc tgctttgttt tcaatctttt tcaaatgcgc ctcaagcatg gcaaaaaggc 1929121 tttttgccat ctctatatga tccgtatgcc gggacaggta tttctttacc cagtgaagtg 1929181 tcttatgatc ctttgtgaca gggatatact gcctgctccc ttgctgttta tgggatagga 1929241 cctgcacaag cagcgaaagc cttttccaaa gcacgccggc agcctgctga taatgagcgc 1929301 cgtgacaatg aacgggccaa ggccgctcgc taagggcatg tctcaaaact gctgcgccgc 1929361 tggctgtcac tttgtatgta tctgattcag acattggcgc gagatatgaa tgcttttcaa 1929421 gcttgtcaag cgacgcagaa atatcgcttc tcgaacattt tgccgccatt ccaaagtatt 1929481 ttgcagtctg aaataagccg gcatcttgaa tggtctgtga cgatctcttg cctttgaata 1929541 ggtgaaaaac agcgcttccc gaccgttccc cgtttatttt gcaaagacaa tcgagaacca 1929601 taatatcgaa gtaatttaat gacaacctat ccacctacat tcttcctgac aaaaatcgtt 1929661 gatttgctct ttttatttta acagatttca aacagaaatc gacgtttaaa gtcatcatta 1929721 agggggatgt tatgtagata accccttatg tgataagcat tctcaatcat ttttctgttg 1929781 aaatgtggca gcaacatcat tacaataagt aagaggaata ggtgttaaat tgattaaata 1929841 taaagattga tccatttgtt ccaccaagaa caatctggga ggttttattc atggcaaagt 1929901 acacaatcgt agacaaagat acatgtattg catgcggcgc ttgcggagct gctgcaccag 1929961 acatttacga ttacgatgat gaaggcatcg cgttcgtaac gcttgatgaa aacaaaggtg 1930021 ttgtcgaagt tcctgaggta ctggaagaag atatgattga cgcatttgaa ggatgcccta 1930081 ctgattccat caaagtggcg gatgagccat ttgaaggcga cccgcttaaa tttgaataga 1930141 agtaactaaa aaaagctccc gaacgggagc ttttttattt aatggatatg tgcacttcgc 1930201 tgctgctcaa tccatggctt aagcttgata aaaattagtg agaatacaac cgtaattaca 1930261 atacctttta tcatgttaaa cggcaggata cctgcgacga ctgctgtttt tagcgcgctg 1930321 tcggataatg ccggtgaatg taaaaaccac gtgtatgccg gaagaatcag aacataattt 1930381 aaaatactca ttaaaatggt catcgctgca gttcccaaaa gcaggctgac agccaagccc 1930441 tttgctgagt tgagtttttt aaataagaaa gcagtcggta atataaagag tgttcctgca 1930501 ataaaattcg caacttgccc tacaggaact ccggccatgc ttccctgaat gatatactga 1930561 agaacatttt ttatcgcttc tacggcaata cccgccaaag gtccgtaaat cagaatggca 1930621 ataattgcgg gaacgtcgct aaaatcgatt tttaaataat ccggaagacc cggaaacggg 1930681 aaatttaaca gcatcaaaac aaatgcaatg ctgctcagca tgctgaccac aactaatttt 1930741 tttactttca cttcattctc tccttttcga tcacatctta ctcgaaaacg gaaaggttct 1930801 tttccagcca ataaaaaaac cgcttcatat ataaaagcgg ggtttcgaaa attaggctag 1930861 gcaaagaaac gtttgaaaaa ttcaatttca aaacgcttat gaacctccat cttctcccat 1930921 ccagactgta ctgtcggctc cggaatctca ccgaatcctg ctgtaaagac agctcgcggg 1930981 cttagagcca ttggctcatc accgccggta gggaatttca ccctgccccg aagattgatc 1931041 atatgaaatt taattacatt ataaacgata actggttggc tgtatagaga attgcttcaa 1931101 attaaatata ttacctgcaa gctgtcagat cattgattta ttaggcttta cttttatcct 1931161 ttactgcgtc aatacacgtt gacactcttt tgagaatatg ttaaattatc agatatttag 1931221 tttgtcaatt taggaggaaa tctaacgatg tttcgagtat tggtctcaga caaaatgagc 1931281 aacgacggtt tacagccact tattgaatca gactttattg aaatcgttca aaaaaacgta 1931341 gcagatgcag aagatgaatt acatactttt gatgctcttt tggtgcgaag cgcgacaaaa 1931401 gtaacagaag accttttcaa caaaatgact tctttaaaaa ttgtcggaag agccggtgtc 1931461 ggtgtcgata atatcgatat tgatgaggct acgaaacacg gggtaatcgt gatcaatgct 1931521 ccgaacggca acaccatttc gacagctgag catacatttg caatgatctc ttctttaatg 1931581 agacacattc cgcaggctaa tatctcagtg aaatccagag agtggaaccg cacagcttat 1931641 gtcggttcag agctttatgg aaaaacgctt ggtattgtag gattaggccg aatcggaagt 1931701 gaaattgcac agcgtgcgag agcgttcggt atgactgtgc acgtttttga tcctttctta 1931761 acggaagaaa gagcgaaaaa aatcggcgta aacagccgta catttgaaga agtgcttgaa 1931821 agtgcggata tcattaccgt tcacacgcct ttaacaaaag aaacaaaagg cttattgaat 1931881 aaagaaacga ttgcaaaaac gaaaaaaggc gttcgcttaa ttaactgtgc gcgaggcgga 1931941 attatcgatg aagcagcact tctcgaagct ttggaaaacg ggcatgttgc gggagcagcg 1932001 cttgacgttt tcgaagtcga accgccagtt gacaacaaac ttgttgatca tccattagtc 1932061 attgccactc ctcacttggg agcatcaacg aaagaagcac agctcaatgt cgccgcccaa 1932121 gtgtcagaag aagttctgca gttcgcaaaa ggcctgcctg tcatgtcagc tatcaacctg 1932181 cctgccatga caaaagatga atttgctaaa attaagcctt accatcaaat tgcaggaaaa 1932241 attggcagcc ttgtatcaca gtgcatgaaa gaaccagtac aggatgttgc cattcaatat 1932301 gaaggcacaa ttgctaaact tgaaacatcg ttcattacaa aagcccttct gtcaggcttt 1932361 ttaaaaccgc gcgtagactc tactgttaat gaggtcaatg ccgggggtgt cgcaaaagaa 1932421 cgcggcatta gcttcagtga aaaaatttcc tcttctgaat ctggatacga taactgcatc 1932481 agcgtaaaag tgacaggaga ccgcagcacc tttactgtaa cggctacgta tattcctcat 1932541 ttcggagaac gaattgtcga gatcaatgga tttaatattg atttttatcc gactggtcac 1932601 ttggtgtata tccagcatca agatacaaca ggtgtcatcg gccgagtagg acgtattctc 1932661 ggagataatg atattaacat tgcaactatg caggttggcc gtaaggaaaa aggcggagaa 1932721 gccatcatga tgctttcctt tgacagacat ctggaagata aaattgtgaa agaactaaca 1932781 aatgtccctg atattgtgtc tgtgaagctc attgatctgc cataattaaa aaaactcaag 1932841 ctatatagct tgagtttttt tattgttcta tccccgtgtg tttttatgca aaatatctaa 1932901 gacactcctt agctcagaaa caggaatttg gcctggtgcg gacgcctctt ctccagctcc 1932961 aaaagtacaa gccgatccaa aaacctcacc gctcagcctg ctgatgagcc ctgttgcagc 1933021 cattgacatt gtaataatgg ggcggtctgc atatattgtt ttcattgtat acgtcgcatc 1933081 aagcagtgtt aggagatctc cagtatcatt cggcatgaca gccatttttg gaatatgcgc 1933141 gcctaagtcc tgcatttttc gaagtctgga aataatttca tcttttacag gtgttttttc 1933201 aaagtcgtga tttgacatca ccacatagac gttgttttct tccgccagcg atactaacgc 1933261 ttttacattt gcatctcctg aaaataattc gatgtctatc agatcgatgt cttttgtttg 1933321 gattgccgat tccagcaaag caagatagga gctttcgtcc atctccatgc tcccgccctc 1933381 tttgtgggtt ctgaatgtaa atagaaatag cttgtcttct aaagatttac gaagcttaga 1933441 aatgagcttt gtgaccgctt ctctgtcatt cgctttttca aatacgtcga ctctccattc 1933501 aacaatgtcc ggattcagta attttactgc ctctgcttca ttcagaattt gtttttccgt 1933561 ctttcccatc agcggaatga tgattttcgg catcccttcc ccgatggaaa ctcctttaat 1933621 cgttaacacg ttcactcgtc tcaaatcctt tcaatcttta ccttgtttta ttatacacgt 1933681 acaacttttt tttgaaaatt tctattatat gaatagcaac taaaaaagag ccttaaaggg 1933741 ctctttttag tttaaggaaa tcggatttgg agcagctggc accggaattg catctgatat 1933801 gtcatatttg ccgatttttt tcgttctggt ttccgtaaag gtcacttctg tgaagccaaa 1933861 ctcttttgca gtcaaaagta gtccctcaat cattaaaata ccggcaatag aatcatcaac 1933921 ttctgactcc tttgaaaagc ggatatataa gtgtttctgt ttcttcgtta cagattggac 1933981 agcacccgct tgaataagag gtgtcgtatc ttcttggctg ctcgattcca tttccttaat 1934041 cgcttctttt actgtatcaa aagaatgatt tgacggaacg agaaagtctt gtccttgttt 1934101 attttggtac aagtagtagg atcgttttga ctgtttggga atcgaaattt ccgtaaaagt 1934161 gccatatgag ccaatccgaa ccccagtctc attttgatcc gataaaaatt tgactttttc 1934221 ataaggactc cattttaagg attctttaag caattttttt aacagtgtat catcttttat 1934281 agaaaatgcc gtagctggct gatggactcg tatacttaat tccttctgct ttggtttttc 1934341 ctttatttct acttcatcta tgaaggttgg aattgtaatg gcatgatcaa ggatgcccaa 1934401 ttcactactt tcaaacagca tatcctggat cgtttggtct gcatttgttt tttgaatgct 1934461 gacgggtatg attgcagatg tatcggcatc agcaaccgct acagtgatgt aattgtcttg 1934521 ttccttttca ggaacgacaa acgatgtctg atccaaggac gatgcagctt ttgggctgtc 1934581 ttctgtctca gttttcgtta ctgcgttctc ttgggacgct tctttttgtt gaggctgtgc 1934641 ctgatcaaag aaatgaggag aaataatgaa ggcgatataa accgcaattg cagcggcaca 1934701 cgcggggcca atccacctga cagcgggctt atttttacgc tttgccatcg tcagccgctt 1934761 gtaaatatcc tgaggcgaac gatggtcttt aactgccgga agttgactta acaactcctt 1934821 tatctgttct tcgttccatt ctgacttcat catccattag ctcctccctc aaaagctcca 1934881 tatgtttccg aagtactttg agccctctgt gttgggtcgt ttttactttg ctttccgaga 1934941 agcgcagagc cttggctgtt tcctgtattg aatatccctg aataaaccgc aagataatca 1935001 cagctctttg atcgattgta cattgatcaa gcgcagcata aatttcccgg acattttcat 1935061 gttgaaccgc aagttcgtcc ggcagcaatt gctgatccct gacatcctgt gtatcccagt 1935121 caaatgtacc gagtatacgc tgtctgattg tttgctgttt acggaaccag tctatcgcaa 1935181 catggcgtgc gatagacaaa agccatgttt tttcactgct tcttccttca aacgtatgat 1935241 aagaatttaa tacccggata taaacctctt gaagaaggtc ttctgtctgg tttttatcct 1935301 ttaccatata aaataaaaat tggtacaaat cttgatgata tgtatcatat aataattgaa 1935361 aggtttcttc catttgaaac ccctccgttc acttttttgt cgtatgaata gcttgaaaag 1935421 ttacattaca actatattac gagtaactgg aatttggaag ggaatttata ttaacatatc 1935481 cttaaatttt attaatgttg gctattaaaa aaacacccgc tcagtcagcg ggtgtttctt 1935541 atggaacaag attcttcggc aaattcagac tcgattttac cgttttgtcg gaatataaaa 1935601 agaaaatgtt gttcctttat ctattcggct gtgcacagta attgatccgt tgtgggcttc 1935661 cacgatattt ttaacgatag ccagccctaa cccggttcct gctctgcccc ttgtccgcgc 1935721 tttatctgcc ttataaaacc gctcaaagat aaatggcaga tcttcttccg gtatgccaga 1935781 cccggagtct ttgatatcaa ttttcaatcc atccttcaca gaatggactg aaatggagac 1935841 actgccgccg gctgaagtat gccgcagcgc gttatcaatc aaattggtaa atacctgctc 1935901 catcttgtct tcatcaaaca taaattcctc ttctgtgaga gaaatgtcat gatctaaagc 1935961 aatatttttt tctttcgcaa caccggaaaa cttccgaatg atcttttcta aaaactcatt 1936021 cacattgatt ttttcataat gtaagcctgt atggcctgat tccattcggg ctaaatcaag 1936081 caaatcatta actaaacggc ccattcggag cgattcgtca taaatgattt gggcaatttc 1936141 tttccggtct tcttcagagc ttgcaatgtc atcgacaatt gcttcactgt atccctgaag 1936201 catggagatc ggtgttctca gctcatgact gacatttgcg ataaagtcct cccgcagctt 1936261 atcaaggcgg cgttcttctg tcatgtcacg cagtacggca accgctcctc tgacgtgcga 1936321 ttccgcataa agcggcgaca tcaaaagcac ccatgatctg ccttgaagcg tcatctcaat 1936381 catttgttct ttttcagtgc tgacagcgtt ttgaaacagc tcttttgctt caggcggaag 1936441 attgtcgcct tctttgatat tcatgttctg ttcataatac caagcctgaa gaaaacgttc 1936501 agccggcggg ttggtcacaa gaatcgtacc gtcaatatta atggtaataa ccccgtcagc 1936561 catactgctc aaaatgttag aaagctgctc tttttcttga ttgagcgcat tgatatgaaa 1936621 gttaagctgc cggcccattt gattaaaagc ggtcgccagt tcaccgattt catcctgagt 1936681 taaaatcggg atttttgtat cgaacttgcc cttcgccaaa tcctgcgcgc cttctctcat 1936741 ttttcggaga gggtacgtga ccctgcttga taaaaagaat gcgaaaaatg tggtcagcac 1936801 aatcgcaatt ccagcggcaa gaaaaatata gcgggtcgta tgttttgttg tatctttaac 1936861 ggcaagcaaa gactgggata aaaagaccat gcctttcttt ccgtcttttt catacgggac 1936921 acctacaatc aggcgttcat tatccgtgtc tgtatcgctc agtcccgtcc gtttgcttac 1936981 ttttttatgg tctttgagag ctttatttaa gtctttgtca tgctgtattt gctcaaccgt 1937041 aatagacgac aggcgatttt tatcattcgg agaataccag tggttcttct catcctggat 1937101 gatggcaatg cttgttaagt tatcagcgag ttcccaagtg attgaccttg ccagtgcctg 1937161 gtcctcgtga ttttctagga tgacagcaac tttattcgca agctgtgtta aatcattctc 1937221 agcttcttcc acatggtagt tttcaataaa ctccagcaaa agaaccgtta aaatgaacaa 1937281 tacgatcaag acgagtgaaa ggatcgtaaa ccacagcttg cctactacgc ttttccaaaa 1937341 tttcattcag cgccgacctc aaatttataa cctacacccc atacggtgac aatttttttc 1937401 gcagcttccg gagatacctt gttcagcttc tctctcaagc gtttgacgtg agtgtccact 1937461 gtccgtaaat caccaaaaaa ctcatattgc cacacttctt tcagaagctt ttcccgatca 1937521 tacaccttgt caggcgtttt cgctaagaaa tatagaagct catactcttt tggcgtcagg 1937581 ctcacttctg ttccatcagc tgttacgcgg tgagcatcat ggtctattga cagatgtgaa 1937641 aacacgagca catttttcgt cggtgtattg gcattgaaat aagaggtttg ggatgctctt 1937701 ctcaaaaggg cctttacacg cagcacgact tctctcgggc tgaacggctt aacaatataa 1937761 tcatctgttc ccgcttcaaa cccctgcacc cggtttgctt cttctccttt tgcggtcagc 1937821 ataataatgg gtgtcgcttt tttttcacga atttgccggc acacttcaat tccatcagtc 1937881 cccggcatca tcagatcaag caaaattaag tcataattgg cttcaagccc tttggcaatg 1937941 gcttcatcac cattttcagc ttcatctata gcataatttt cacgttcaag atacattctt 1938001 aaaaggcggc gaattctggc ttcgtcatca actactaata tttttgtttc gttcgtttgg 1938061 tccatgtttt ccccctgctt tccttctgtt actttcattt tatcaaatcg tgagaaagtt 1938121 tgagaactgt gtcgctttca aaggactatg cataagaatg aagtccggca agcacaagat 1938181 ttacgaatat taaattaaac ataataatag caaaaccgat tacggccagc catgctgact 1938241 tctcaccgtg ccagcctctt gacagtctta aatgcaagta agcggcatag aacaaaaatg 1938301 tgatcagcgc ccatacttcc ttagggtccc agccccaaaa tctggtccac gcgagctgag 1938361 cccaaatcat tgcaaagatc agcgcgccga gtgtaaagat cggaaatccg attgatacgg 1938421 ccctgtaccc aacctcatcc accagatcaa gattgacgtt tttcaccagc ggatgtaata 1938481 gagcgctgat tctttttctg atgatcagac ggagagcccc atacaacaca agacctgctc 1938541 caaatgacca aatgacagtg ttcacttttc tgcctgagaa aagcgcggga agatcaacaa 1938601 gcggttccat tcttccttcg gtcaaaagct ctccctgatg cggaccgaca agcgcgggca 1938661 tttcgtacac catcacgctt ttttctttac ttttgtccac ccagttaaac tccgcttcat 1938721 agcctgcaag acgaaatgcc gatgtgattg caataaaggc gacggttgtg accaggataa 1938781 acataatcgc ttcaagccag aaggtctttt tgcttggctt tgtctggtct acatgcttca 1938841 aaagaaagat gacaccagcg acaaagctga tggcaagtat agcttgccca agcgcggccg 1938901 ttgttacgtg aatatacagc cagttacttt ggagcgaagg aattaaaggc gagatatctg 1938961 tcggaaacat gctggcgtag gcaatcagca ataaagcaat tgacagcgta aacaggccta 1939021 atgaaggcaa tctatagaga aaataaagaa tgataaacgc caaaacaagc atcatgccaa 1939081 aagcggtggt gaattcaaac atattgctga caggcgcatg gccgcttgca gcccaccttg 1939141 tgatgaaata tcctaggtgg cagaaaaaac cgacaataga aagggtgatt ccaatgttgg 1939201 cccatcggtt tggcctgccc tttttatctt tattcccgcg tatggccccg ccgaagattg 1939261 ggacagcgat taaatacaca agaaaggccg cataaagaaa atttccgctc agctctgcca 1939321 tgacatcact cccttttcgc ctatttctgt gttttgatta attctttttg gtccaccggt 1939381 tcagtcagtc cggaatcagc caatataaat gctaaatcct tcttcaggcc aaaccagttt 1939441 ttattggtat gccctgctac cataactgca ccgtcctgtg agtgcagcca aattcttcga 1939501 tgctgccagt acataccttg aatgacaccg atcataaaaa tggctccgcc gacagcaagc 1939561 acccagagtg tcagatcctt tctgactgta agtccagtaa tgtttttcgt ttcgacatgg 1939621 tcaaatttca gcttgtattt attattgcct gatccttcga tggtttcttg gatggcgaca 1939681 aagctctttt cgcctttcgg tttgtccggc gttatgatat taaagacaaa agccggattg 1939741 ttagggatct ttgtttttgt gctcggctct ccgtcctgat taaaatagaa gtcaggcagg 1939801 tagctggcga tttccacctt gtaaccgtta ccaagatcat agactgaatc tggatccaga 1939861 aggttgatct tcaggctccc aaaggatttt tttgtttttt tatcaatcag ctggaacacc 1939921 atttggtcaa gctgattctc tttgtaatcc acctggtaaa cggaaaaaga atcaaaacgc 1939981 agcggctgat tgacacggat gtcttcttct gttacttttt ccagcttcgg cttctcgcca 1940041 taaacaattt ttccttctct cttgtagagt acggcatcag tttgaaagtt ctttgccact 1940101 ctaccgtccc cgactctgtc aatggcatct gcaaatacct ttttttccgt tttgctgtta 1940161 taggtctcta cgctgaattg attgtttttc aaataatatt ttccgtctgt acccggaatt 1940221 gctgcggttt cgccttctct gacccaaagc gtctcatcga cgtacatgcc aggcacaaat 1940281 ctcagcatcg caccaatcag aaagatgatc aatccaatgt ggttgacata cgggccccag 1940341 cgggaaaagc gtcctttttc agcaagaatg ctgccctctt tttctctgat tctataatgt 1940401 tttttcttta atagagtaac tatcttttct ttcgattccc cgttcagtac agtaactgtt 1940461 tcactgaaca agcgctgcct tcttaaaaag gccgggctcc ttctgacacc ttggtttttt 1940521 aacgctctat acaacggaat gacccgatca aggctgcaaa tcacgagtga aatgccgatc 1940581 gaggcaatga gcagcaaata ccaccaagaa ccatataaat gatgaaaccc gagcaaataa 1940641 taaagctggc caaacgtgcc gtactgctcc ttgtaataag tatcagcctg tgcgcccgga 1940701 ggcagatagg cttcctgggg aaaaatggtg ccgaacgctg atgcggcaag ggttatgacg 1940761 ataagccata ttcccacctt aaccgaggaa aagaaattcc aaattttgtc gatgatcgtt 1940821 ttgttatagg tttgcgaacg tcttgcgctt ccgtcatatc tcatatcagc gagcggaggt 1940881 tgagtttcct gaagagctct tccgcacgat tcgcataaaa cggttccgac cgggtttata 1940941 tgtccgcatt cacatttgac ttgcttcatc ccgaagtctc tccgggtttt atgagattca 1941001 tataatcgtg tatcatgctt tctgtcatag tgccggtcac caccttgaca acttttcctt 1941061 ccggattgat caaaaaggtt gtcggaagcg gagatacgtc ataggcatca agcacttggc 1941121 gatctgtatc cagaacaacc gggaaattga ctccgtagga tttcataaaa ttatgtactg 1941181 ctatctttga ctccccaaca tttacagcga caatttcaac accttggctt ttaaaatgct 1941241 tatattggtt tgccatataa ggaaactctt ttttgcacgg ttcacaccat gtaccccaga 1941301 aattcaaaaa aacacctttc ccttttaagt cactgagctc gatacgtttc ccattcgtat 1941361 cctctaggac aaaattcggt gcgtcggacc cttcggatat actctctttg ccggcaaata 1941421 cagcgttgta aatggtatag ccgagtgcgc agattaaaac gagaaggatg ccggtccgaa 1941481 tgaataaacg cctttttttc ttcattgtcc actgccccct tccccctatt gcagatccat 1941541 tcaattatat cattgcacgt tcatttcaca tttcttactt tttgaaggtt atgtgaaatt 1941601 tagaaagcgt ttttaccgtg atccgccagt gctctgagcc tttttacttc gtgaggcgta 1941661 agctctctgg catcgcccgt gtgcaggcct cgcaggttta aaaacgcgta ttcctcacgc 1941721 ttcagcttga ttacctcatg tccgatcgct tcaaacatgc ggcgcacttg tctgttgcgt 1941781 ccctcatgga tcgtcagctg aataatgctt gtctgctttt tcttatccaa agacagcagc 1941841 ttcgctttag caggcgctgt tttgccttcc tccagcctaa ttccgcgctc cagctttctg 1941901 agcagctctt taggcgggat tcctttcacc ttcgccacgt atgttttgtc tatttcatac 1941961 ttaggatgca ttagcttatt ggcgaattcg ccgtcattgg ttaaaagcaa aagaccgctc 1942021 gtatcatagt ccagacgccc aatcggataa atgcgctgcg gaatattttt aaaaaagtcc 1942081 gtcaccactt tgcgtccttt atcatcttgc gctgcggaaa taacgcctct tggtttatat 1942141 aagagaaagt aaaccggctc ttcgcgttca acctttaacc cgtttacctc aatctgatca 1942201 gaaccggtga ccttaacacc tagctctgtt actactttgc cattcacctt tacttttcct 1942261 tctttaatca gctcttctgc ctttctgcgc gacgcaactc cggcatgagc aatcactttt 1942321 tgcagtcttt ccatgtcttt cacctcaagt attatcttac ttttttcaac cttaacaaac 1942381 aagctttttc aaattcctat gccaaatcta aaaaaaacgc cgttttcagg cgctcccaaa 1942441 taataacgta acgatgatga tagatgcaac tacgccgatt aaatctgcaa gaagtcccac 1942501 ctttaatgca tcacccattt ttttaatgcc gactgctccg aaatacacag tcagtacgta 1942561 aagcgttgta tctgtagatc cctgcatgac ggaagccagc ctgccgataa aggaatcggg 1942621 cccgtatact gcaattaaat cggtcgtcat tccaagtgcg gccgtaccgg agatcgggcg 1942681 gatcagagca agcggcacta cttcagcagg gatgccgata gcggagaaag ccggttttaa 1942741 aagatccatt ataaaatcaa gcgcgcctga tgatctgaaa acagttatag cgacaagcat 1942801 tccgactaaa taggggataa tggaaaaggc aatttctatc ccctctttcc cgccttcgac 1942861 aaacgattca tatgtcggaa cctttttgat cgttccataa agaagaattc cggcaataat 1942921 gattggaatc atggctaaag acagccagtt gatgatttcc atccgctcac cttcccttct 1942981 ttttgcggcg gtaataaaaa taccgatcaa tgataatggc accgattccg gaaataagcg 1943041 ttgccaaaat gcttggcccg acgatatctg tcggcgtttt ggaggaataa gccattcgga 1943101 cagcgatcac cgttgtcggg atgagtgtga tgcaggacgt attaacagct aaaaaagtaa 1943161 tcatcgaccg gcttgcttcc gatcggtttc cgttcagctt tttcatttgt tccattgctt 1943221 taatgccaag cggagttgct gcatttccga ggccgaagaa attcgccata agattagata 1943281 aaatatagcc catcgccggg tgatccggcg gtatatcagg gaacagttta gatataaaag 1943341 gtctgcacat ccggctgaaa atatccaaaa gccctgactg ctcggcgatt ttcattaagc 1943401 caagccagaa aacaagcacg ctcatcaatc caaatgagat cgtaatcgct tctttcgcac 1943461 ccttaaacac ggcttcattt acatcttgca gagttccgtt gcacatcgca aaaacgagtc 1943521 cgatcacggt taaactgacc caaattatat tgaccatttt gctccgcctg ccgcattcag 1943581 aaagattgat ttaaacgttt caaaaaattg tttcttcggt ttttgatgcc gctcattttc 1943641 ataatagatc ggcacttttg cgatggttgc atcgttgaac atgatctcca tgtgccctac 1943701 gatgtcaggg attttcgagg catctttttc ccatgctttt ttcggcttga gcagtgtggt 1943761 attaattttt acattttctt tttcctcttc ggtcagcaaa taggtgatat cacgtttgat 1943821 aaaagccttc gattcataaa atgtgccttt cagctttgga atatcccctt tttttgcaat 1943881 taaataggtt tgataatgct caaacacata gttaaacatc ttcatatggt catcccaatc 1943941 attagggtca ttaatggtga cggctatcag gtcaatgccg tcctttgaag ccgtagagac 1944001 cagtgtccgt tttgcaagtt ttgtatagcc tgtttttcct cctgtgctgt acggataaag 1944061 catggtcagc agtttgtttt tgtttttcca tacgctttcc atcgtttccg ctttgtatat 1944121 ttttgtgcct gaaatctttt gatagtcttt cagcttcata gcatacttag ttaaaatggc 1944181 catgtcatag gctgttgaat aatgattttc atggtcgtcc aatccgtgcg ggttttgaaa 1944241 acgggtgttt ttcataccaa gctgctcggc tttttgattc atcatataaa caaacccatc 1944301 gaggctccca ccgacatgct cagcaatcgc gacagcggca tcgtttcctg atcttagcat 1944361 caggccatac acaagatctt tcagcttcac tttttgacct tctgttaaat aaatggcgga 1944421 gccttctgtt ctgacagcat ttgccgaaac cgtcactgtt tgatccattt tgccggattc 1944481 gatggcgagg acggcggtca taatttttgt gatgctcgcg atccgccttt tttgatgctc 1944541 atccttggca tataacactc tgcctgacgc accgtcaata atgatcgcgc tttttgcact 1944601 gacatctata gcagcatgtg ctgtattcac atttacggtt gcaataagaa aagaaatcat 1944661 gatcacgaat actgcttttt tgaaaatgcg catgtttgct cacgtccttg tggtggtttg 1944721 tacaagttta tgcgcatgtc catcagttat gaataacaat tatatttctg gaagcaaaca 1944781 taaaaaaact ctccctgaaa aagggagagt aaacgttatc tgattggcgc catgcttgat 1944841 ccggacgctt cgtaatgagc cagctcttcc ctcatcttca gaaaggccgc gctcaacggc 1944901 aataataatt gctcaagcga cgcaggaaca gcatgataaa actcaattgc gctgaccccg 1944961 gtataagacg cccggctatt ttcacaccac gtgtcttttt tcggcataaa gaactcttca 1945021 atgcattggt gatacacatt ataaagtgtt ttttccgctc tggcttcctg aaaaggctcc 1945081 tgcatcagga gacgacggca cgcttctgcg cctccttcac aaaatactgc cattcttctc 1945141 agagtgctaa gcacatcaca gcagtatcct ttttcaatag gcaattcagc ctgtaaggac 1945201 tcaagcgtcg tttgatttag gtaatcgttc acggtattga caaccattga taagaattcg 1945261 cctgtttttt gagtctgcgc tcgcacaatc gaatgtccca tttcgtttgg tatcttcccc 1945321 tcatgtattt gtctctcaca ttttgcttct ttcatgatag cttcttcctt atatcttatg 1945381 atgatgaaaa agcgcgattc attaaacttc tattttatat cttcgaaggt ttggttaaag 1945441 ttttcaaaaa ataaatctgc ttcttcttga agaacgtctt cttccgcatt ttcaggcagc 1945501 ggcggaagct cgtccagcgt tttcagaccg aattgttcaa gaaaagtcgg cgtagtaccg 1945561 tataaaatgg cccgccccgg accatcggca cgccctactt cacacaatag cgccttcgcg 1945621 acaagactgt gtaaaatccg ctctgatttt actcctctga tttcttcaat ttctgctctc 1945681 gtaattggct gtttgtatga aacaatggcc agtacttcta aagatgcttg agaaaggccc 1945741 tttgacggca cttcaatcag ttttttcaag taaggcgcaa agtctttttt ggtagagagc 1945801 atgtacgtat ctgcatactc aataagttca atccctcgtg tatctccgcg gtattcgtcc 1945861 gccacatccg ccatgatcgt gttcagttca ggctcttcga tttcaagcac tgttaacagc 1945921 tgcttttttg taagcccttc atcgcctgcc gcataaagaa gggcttccac aatagctttc 1945981 caattcacga tatcaagccc catgaatgga ttcactcccc gtaatgtaaa tatctgaaaa 1946041 attgtgctcc tgttcaatga ggaccagctg atttttcatc agctcaagaa cagctagaaa 1946101 ggtcactact aaatgttctt tttgctcata tggaaacaga tccataaagt taattctcgt 1946161 tcctctagat ttcaagctgt gcacgatttc gttcattctg gcttcgattg gtatgtcctg 1946221 tcttgtaatt gttgtttcca tcggcctgtt tatttttttg cgtttcagca ctttttgaaa 1946281 agctccgatc atatcataga ccgtgacaga gagcttttgc tcagactgtt ttacttcttt 1946341 tgcatattca ctcaaatcac tcggcggttt cgtgaacgat ttttgtcttt cttcttcccg 1946401 ttcttttaaa tccttcgccg catctttata ttttcggtac tcaatcagct tttcaatcag 1946461 ttcctcccgc ggatcttctt cttcaagtaa ttcatcttca aaaagctcct cctcttgctt 1946521 cgggagcagc attctgcttt taatgctgag cagcgtggca gccataacca aatactcgct 1946581 ggcaatgtcg agctcaagca cgcgcatcgt atgtacatat aataaatatt gttcagtgat 1946641 cttcgccaca ggtatatcat atatgtcaat ttcaagacga ttgattaaat gaagcagcag 1946701 gtccaatggg ccctcaaacg tatcaatttt cacttgatat tcttccatca tctcaccatt 1946761 ttcaagtatc actctcattg ccggaaaaac tggctaccct atagtataag ccaccaaaaa 1946821 gctctcgtcc aatactattt catatcctgt tttgaaggag tttgtacaga atattcaaaa 1946881 cacaagaggt gtttgctcgg agcgcagaag cgggagaaaa agcctttgct tctggttttc 1946941 ctttctaaga agcactagag gccgggcgtt cttttttcct tttatccctt ctatggtaca 1947001 ctaaaagcac attaaaggag gaagcacctt gtatccgaaa gcttatatag attatctcgt 1947061 tgagtttcat gcgacacggg attattttga atgccatgaa atattagaag aatattggaa 1947121 ggaagatccg ccaaagaaac gaaaacgcta ttgggtgggc tttattcagc ttgcagtggc 1947181 tttatatcat cacagaaggc agaatacagc cggggcaaaa agactgatgg cgaacagcat 1947241 ccggattctt caagcagaac accgggcagt cgaagactta gggcttgatc atggccgttt 1947301 gctcgaactt atgcaatcgg tttacgaaca aatcgaaacc gtctctgcct ataaaagcat 1947361 tatactgcca atcaaagatg agaaactgga ggaagcatgc aggatcgaat gcaggaaaaa 1947421 aaagtataca tgggggcagc ccagtgcact cagcaacata tttcttatcg acaaacaccg 1947481 tttgcgggat cggactgacg tcatccgtga acgtgaaaaa gaaatagaac gcagaaaaaa 1947541 aagcagagac tgatcacagc ctctgcttaa ttattgtatg aaatgtcttg atcctgctga 1947601 ccttgacaac gttcgaaaaa gctctgcgtt aattcatttg gaaccagtac ttgcgttttg 1947661 aataaatgct ttaaagcatc catcatctgt tttccgattc cttgatggcg atgagaagga 1947721 ttcacactga tatgccggat ctcaacctca gaatcctttt tttcgactcc gattgctccg 1947781 acgatatcct cgtcctcttt ccaaagaaag agctggcggt ctgtatccgt ttcgtagtcc 1947841 ttaattgtct gctgaagctg cttaaggtct ttttcattcg gcataaacga aagaagcccc 1947901 atcgcaatct tttcaaacga ttttttataa cgaattaaca taaaaacccc tctatatcca 1947961 aaatgtccag tctgctatta acggatacga ataggtgatc cgttttctca cattatatca 1948021 ttttcgccat atttttaaac tgttttcagc aaattattca aatgagcggt ttaaatttgc 1948081 catttcaatg gcagaaacag cacaatctac acctttgttg cccgcttttg tgccggcacg 1948141 ctcgatagcc tgttcgatgt tttcagttgt tacaattcca aagatgacag gtacaccagt 1948201 agtgtttgct gcttgcgcga tgccttttgc agcttcattg cagacataat cgtaatgtgt 1948261 cgttgcgcct ctgatgacag tgcccaatgt gataatagca tcatattttt ttgtttccgc 1948321 catttttttc gcagcaaacg gtatttcaaa tgcgcctgga acccaagcca catcaatgtc 1948381 atttgtgtct acgccatgtc tgagcagcgc atcttctgct ccgctcagca gcttgctcgt 1948441 aataaaatca ttaaatcttc ctactacgat tccgatttta agacctgtac caactaaatt 1948501 tccttgtatg atattcatat gattcccatc cttttttgtg atatttgtga ttagaaatga 1948561 agtaaatgac ctagcttgtt cattttggtt tgcaaatatt ttttattgtg ttctttcgcc 1948621 tccatttgaa gcggcactct ttctgaaata ctgagtccgt agccttcaag gcctgcgatt 1948681 tttcgcggat tattcgtcaa aagcttcata ttccggacac cgaggtcgcg taaaatttgt 1948741 gctccgatgc catagttgcg aagatccggc aagaatccaa gcgcctcatt ggcttctacg 1948801 gtgtcatagc cttgttcctg aagcttataa gcttttaatt tattgattaa accgatgcct 1948861 cgtccttctt ggcgcaagta caggagcact ccacggcctt ctgcggcaat ttggttcagc 1948921 gcggcgtgca gctgcggtcc gcaatcacag cgatgagagc caaacacgtc acctgtgaga 1948981 cattctgaat gcacccggac caataccggt tcttctccga acggcacatc tcccatcaca 1949041 aatgcgacat gctcttttcc atctacctca tttgtgtatc cataaacctt aaatgtccca 1949101 aaatcagtag gcagcgtaat gtcaacttca cgctcgacaa gtgttgtcag attgtaacgg 1949161 tattgaatca aatccttaat ggtgatcatt tttaattgat gctttttcgc aatttcaatg 1949221 agctcaggca ctctcgccat cgttccgtct tcattcataa tttcacaaat gacgccggct 1949281 cctggagatc cgcaagcttc agcaagatca acagcagctt ctgtatggcc cgctcttttc 1949341 aggacacctc cttttttcgc aatcagtgga aaaatgtgcc ccggacgctg aaaatcagat 1949401 ggcacggatt tgctgtccag caatgcttga acggtaaaag atctttcttg agcgctgata 1949461 cctgtcttcg tttcacgatg gtctatgctt acggtaaatg cagtgtggtg agagtctgta 1949521 ttatgctcaa ccatagggtg aagatcaagc ctgtctgcga tttcctcact gagcggcgtg 1949581 cagatcagtc ctctcccatg tgtcgccata aagttaatga cttccggcgt tgcatgctcg 1949641 gcaagagcca caaagtctcc ttcattttct ctgtcttcat catctacaac gatgatgact 1949701 tcgccttttt ttaaagcgtc cagtgcttct tctatcggat gaaacatgca aatcttcctc 1949761 tctaaaagcc gttttcgctt aagaaggctt ttgtaatggt ttgttgggtc ttattttcat 1949821 tggctttatg caaaaatcga tacatatatt ttccgatcat atcgcattcg atattcactt 1949881 tagagccgat cgttttttct gaaaagatcg tttcgctgat cgtatgcggt attaaggaga 1949941 tcgtcactgt gtcttctgtc aggccgaata tggttaagct cacgccatcc acagtaattg 1950001 atccctttaa aaccaatgtt tttgttaatg acgggtccat ttttaaatca tagtaaactg 1950061 cgttgctttt ctcttcaatt cgtgtgattt ccgcagttcc gtcgacatgg cctgagacga 1950121 aatggcctcc gaaacggccg tttgccgcca tcgctctttc cagatttact ttgcttcctt 1950181 ttgttaaatc attcagtgac gtagctttga ctgtttcagg cataacatcc actgtgaatt 1950241 gattttttgt aaaatcagtg acagtcagac aaatgccgtt cactgcaatg ctgtcgccaa 1950301 gatgaacatc ctctaaaatc tttgagcatt taatagttaa ggccattgca tgccctgctt 1950361 ttttcatgga ttcgattgtg cctgtttctt cgataattcc tgtaaacatg gtcaccatcc 1950421 tattcctttg tcggttttgc cgtcagtttg atatcacggc cgatttgggt tatatcagtg 1950481 aattgtaata aggggacatc tttcattgat tgaaaacctt caccggagat taagctggga 1950541 gcatgcgttc ctccgattag tttaggggca aaatagaaga tgatttcttg aaaacagcct 1950601 tctttgacaa agcttccgtg aacagctgaa ccgccttcca catacaccga catgatgcct 1950661 tcttccgcta ggatcttcaa aacatcagga atttgaatgc gctcggtttc aagtgtaaat 1950721 atgttcactc cgaaagctga aagccgtttt ttcttttcct cgtctgcgcg tgccgtcgta 1950781 aaaatccatg tcggcgctat ttgatcgcaa atcactttag cgtcctcagg aatcgagagt 1950841 acggtatcaa gtatgacccg aaccggctgt tttgttacat tcggcagtct gcaggttaag 1950901 ctcggattgt cggctttcac tgtgccaact ccgactaaaa tgctttggtg tgttttcctg 1950961 tattgctgag catcctgtct tgcagcctct gacgtgatcc atttgctgtc acccgtgctg 1951021 gtagctatct tgccgtcaag gctggcagcc gcttttagcg tgacgtacgg aaggcctgtc 1951081 ctcataaagt gcagaaattt ttcattcagc ctctccgcct ggtctgccag gatgccttcc 1951141 cttacctcaa tgccagcttc tttcatcatg ctgatccctc ttccagccac aagcggatta 1951201 ggatctctca tcgccacgaa cactcttttg ataccagagt tgataatcaa ttctgcacat 1951261 ggcggtgttt ttccgtaatg gctgcacggt tcgagtgtaa cgtaaatgtc ggcaccctct 1951321 gcatgtgctc cagccatatg gatggcatga acttctgcat gagcttcacc atattttaaa 1951381 tgggcgccca ttccgacaat ttgtccgtcc tttacgacaa cagcgccgac gagcggattg 1951441 gattcggtct gtccttcgcc ctgcttcgca agatctaagg ccagcttcat ataatactct 1951501 tccatttgtt tccctcccct cttttgttat ttaccgtcaa aaaagccccg aatttataaa 1951561 aaattcgggg ctttaggtat tttacgcaat aggaaataac actatgcatt tttaaacatt 1951621 ttgcatagcg gctcatcatc cttctcccat ccagactttc actgtcggct tcagcttaaa 1951681 ctgaatccac cgcgtgctta tgcacacggg tcacgggctc taaagcaaat gtgctttact 1951741 accgccggtc gggatttcca ccctgccccg aaggatacaa tctttattca tttgtcctta 1951801 ttggttatta tagcgatcct ttttaaagta cgcaatgaaa taaacttaca atttgagaaa 1951861 aacaaaacat cacccttcga tccgaaaggt gatgtttttt aatcattcac ttttgcaacc 1951921 ttgattaatc cgtcgatccg ctttgatttg ctgaagtaag ccttaatctt gtcaccttct 1951981 tttatatcag ataaatcctg atttaatttt tttccgttga agatgatttt cgttccgttt 1952041 tctgctactc catgatactc tgagccgtca attttcgtca ctttatattc ctggatggtg 1952101 tattcctctt cttccgagga caaggtttgt ccaattgctg tcggaacatc cttcagctca 1952161 atatcattta tgtacatata accgcctgca agtaaaagca aaagcactaa cagaatggta 1952221 atcttggttt ttattcttcc catttctaaa cctccagcca atatgaatct attcattcat 1952281 atgagttatt cctttttttc atgaataaaa aaccgtaaat tctcgtaaat tattaatata 1952341 acgatgcata acgggaatat gtttcacatt tctgcaaaaa tttcttttct atagatatac 1952401 gaatttatgt tctgttttta ggggatgacc gtaaaaaaga tataaaaaaa gcagccccaa 1952461 tgggaagctg cttgatccta atttgttttg cgcatttcgt taaacgggta gaaaacaaac 1952521 tttgacgtac ccgcaatttg ttttttcgtg aagaggccaa ggccgttacg gctgtccatg 1952581 gaattgcgac gattgtcacc catcacaaaa tacttgttat caggcacttt aaccgggccg 1952641 aaatcatcgg tcaaatggtc aaaaccgtcc tgtttcgctc tctttttatt agccgccaaa 1952701 taaggttcgt ccaccttttt cccgttgata tagagctggt catttttcat ctcaaccgta 1952761 tcgccgggaa ggccgataat acgtttgaca tagtgaacat catctccgtt taacacgacg 1952821 atgtctcctc tatcaaactc gccgatgtat ttgactgtca tattaacaaa aaccctttca 1952881 cggttgtgaa gtgtaggata catagagtca ccatcaacga catacggcgc aaaaataaag 1952941 ttgcggatga gcaaagcaag aacgacagca atcacaattg cttttgccca ttctaatatt 1953001 gactttttct tcgaaacatt ttctgatttc aactgatttc ctccaataaa caacggtctt 1953061 caatttatgt tatcacgaat cgaaaaaaaa tcccattagg accattgaag tgattttaca 1953121 aactgttaat cttcatcttc tacccacatc atgcctattt tttcttgtcg atcataacta 1953181 ggcctgaaaa tattgaaaga aatgaatcgc ataattcaga agcgatggac tcagaagaaa 1953241 gagagttctc atatgcaaaa tctttagatc gtatataaag catgaggtta cgggcagttt 1953301 gttcatttac tgcattccat tgatctccca gtccatgata cccatggcac ttgacaaaac 1953361 aattaacgtc atgaaggtta ctggaatgtt tgcggcaacc tatttcacag gtgataaccg 1953421 caccccgttt tttgctttca taatatgttt aaaatcattc aagctcgaaa acatggatca 1953481 gcctccaaaa aataaatcca atatattccc ggcagttgaa gactctttat tataaaactc 1953541 tgaatatccg cagttcttac agtaaaccac tagaaatcgg ttatgctgca cgtcaaacag 1953601 ctttgataat cccgtgccgg ttgtagctat ttctttttgt ccggcttcag tactaccgca 1953661 ttttatacag cctttgttgt tcatatcgcg atctcctttt cattacatca cgtttgtttg 1953721 atttatttta ctacaaaata tcaatcccaa tgacccgtac tactttaaag tttacttaat 1953781 tttgattaca tactaattgg gttcgtttct cagcttggta aatcttctgg agaaacggaa 1953841 aagctccatg accaaaacat tcaaactcag ccaaacaccg ccgaaggcgt aacccgcagc 1953901 aacatcactc ggatactgct cataaagtac acacggctca gcccgatgag gaataaaacg 1953961 ataataaaca aaaaaatgca acagtttgca gacgcgtctt gtgagaatga cgaacaaaaa 1954021 gataagcaca aaaaccaaaa atgacaaatg ccgttaaagt ctgttcgctc gggaatggat 1954081 ataatacatg actttccaaa ggagcgtgaa caggatgaag ggaatgaaag agccgtctga 1954141 ttccctcttc ataaagctcc ccaccaatga ctaggaaaaa taagaaagag agttcgattt 1954201 tccgatcttg ccctctgaat accgtccaaa aaaaagttag aacaataacg gctaacagaa 1954261 cacctctcga cgcaaaagct ttctgaattg cagctgggcc cagtctatac ccgatccaat 1954321 acgacatgct cactcccaca gctccccaat ccggccgcta acatgcttag cacccagttt 1954381 aacttttctt gaaacacgag aacaccggca aactctcccg gtccaagtaa agctagaagc 1954441 tctaacatca agacaataaa caagacggca tatccgtact gttcgagcaa ccccgtcaaa 1954501 acttgcatgt gattctcctt aaactttttt gttcttttat cattcccaat ccactttttg 1954561 tataatcagc acaattttat cttcagtcgt ccaacaacat tgtctatggc gggatcttct 1954621 ctcatacatt cttttttgac ataggaggag caatagcatg aaatgggagg aaacaaaaga 1954681 tacgcaggga gtttgccaaa attttgggca gttcgttctg ccaccgagtc aggtgtttgt 1954741 ttgcccacct catcccttgt caattcccca tttttcccgt ttgaggttcg aaatggtaaa 1954801 gtatttcact tagtttctta catgaagagg taaattcttt gctcaccgaa ctaggatagc 1954861 ggcgtatggc gatttctaca ttgcataacc actggttatt tagtgagccg tgagcaatgt 1954921 atatgcactt tgagtcagca caggatgatc ctattacatt cgccagaaaa gcagctgccg 1954981 cattcagagt agttaaaaga atagacagat atctgggctt ccggaagctt taaaggaggc 1955041 tcttttttcg agcattttta taaatcaata aaaacaggca tctcctaaat atttttgccg 1955101 ataagtttac gctaatcaac tctagcacta atacatataa aaaatagaat gatatgaaag 1955161 gagacttgat agtatgattg attatcctat taatataaac aacgtttccg ggaacagtgt 1955221 aattaacgta ggcggcgctt ttatgatcag gcctttaact ttgtccaaat ctgtgtttgg 1955281 ctccggaggt ttaaacacag gaattgtctt tgaaaataac tttgtaagca aagctaaaat 1955341 gattaatcat caatttactg atcaaaacgt caccaaaact ttttaatgta ttcaatacac 1955401 gggggtcact aactaaacac ctggttttgc caaccgccat cagcattcgg cggtttttta 1955461 ttgaacattt ttggccaata aaaaaagctt cctctctaag aggaagcctt ttgcctgccg 1955521 attagccttc tacacgaact tctttcatga catcgccatt agacatgttt ttcgcgaatt 1955581 ctaatccgct tgttacttta ccaaatacag tgtgaacacc gttcaaatga ggctgtggct 1955641 catgaacgat gaaaaattgg ctgccgccag tgtcttttcc ggcatgtgcc atagaaagtg 1955701 cgcccgcctc atgtgtatgc gggttgcctt ctgtttcaca tttgattgtg tatcccggac 1955761 cgcctgtacc agttccgtgc gggcatccgc cttggctgac gaagccaggg atcactcggt 1955821 ggaatgtaag cccgtcataa aagccttcgt tcgcaagctt ttcaaagttt gcaacagttc 1955881 caggtgcagc ttcaggataa agttcaaatt caattttgtt cccgtcttct aataaaaagt 1955941 aacctgtttt caattgtatg cctactttct ttattttaat tttcaaagga gattatgtat 1956001 aggttatagc ctgtctctcc ttgtcgcggc tattatacca cacctttcgg gggaaaacga 1956061 atctcccgag ctttactaaa aaataaaaat gaaacctgaa tctctttatc tccgtctaac 1956121 ctaacggaac tgtatttttc atgattcagg tcctcacaaa gcagcactat ccagctgctt 1956181 gtgaaattga aggaggtcaa actgctttga agaaaatttg gattggaatg ctggcagcgg 1956241 ccgttttgct gctgatggtt ccgaaggtca gtctcgcgga tgccgcagtt ggagatgtca 1956301 ttgtaacact gggtgctgat ttgtcagaat ctgacaaaca aaaagtgctt gatgaaatga 1956361 atgtccctga taatgccaca acggtaaccg tgaccaataa ggaagaacat gaatatttag 1956421 gaaaatatat atcgaacgcg caaatcggat cgagagcgat ttcttcatcg tcaatcacca 1956481 ttgccaaaaa aggctccgga ttgaatgttg agacccataa tatcagcggc atcacagatg 1956541 aaatgtacct gaatgcactg atgacagccg gtgttaaaga tgcgaaggtg tatgttacag 1956601 caccgtttga agtatccggg actgccgctt taactggatt gattaaggcg tatgaagttt 1956661 cttctgacga agcgatctcg gaggatgtta agcaggtcgc caaccaagag cttgtcacga 1956721 catcagagct tggagacaaa atcggtaacg aaaatgcggc agccctgatt gcaaaaatca 1956781 aagaagagtt tgctaaaaac ggggtgcctg ataataaagc tgacatcgaa aaacaagtgg 1956841 atgacgcagc ttctgattta aacgtcacac ttacagacag ccaaaagaat cagcttgtct 1956901 ccctattcaa taagatgaaa aacgctgaca ttgactgggg acaggtcagt gaccagctag 1956961 ataaagcgaa agataagatt acgaaattca tagaatcaga tgaaggcaaa aacttcatcc 1957021 agaaagtcat tgatttcttc gtatctatct ggaatgcgat tgtatctata ttcaaataag 1957081 aaaagcgccg aaaaatcggc gctttctttt attgctttac acccgtttta aatggcagat 1957141 caagttttac aatatcttcg tatgtttctc gcttcacgac taaatgagcc tcaccgtttt 1957201 cgacaaatac aacggcgggt ctcggaatac ggttataatt gttggccatg ctgtatccat 1957261 aagcgcctgt acaaaaaacg gcaagaagat cgccttcttt tacttccggc aggtcaatat 1957321 cccaaatcag catatctccg ctttcacagc actttccggc aattgatacc gttttgtcat 1957381 gcgcttctcc gatcctgttg gctgccgcag cttcatattt agcttggtaa agcgcaggac 1957441 gaatattgtc gttcatgcct ccgtctacag ccacatattg gcggacaccc ggcacttctt 1957501 tttgagagcc aaccgtataa agagttgtgc ctgcgtctcc cacgagagaa cggcccggtt 1957561 cgatccaaat ttccggaatg tcaaaaccgt aacgggaagc attttctttc acagcttcga 1957621 taattttttc aacgtattca gtggcatgaa gcggttcatc atcttccgta taacgaatgc 1957681 cgaaacctcc tccaagattc agcaccttgg atacaaatga atatgaatct ctccattcgt 1957741 ctagtttttt gaagattttt tccgctgcta acacaaaacc ggccgtatca aagatttgcg 1957801 agccgatatg gcaatggaca cccagcagct gaatgtgttc cgattgtaat acttgttcaa 1957861 tggcccgttc agtttgtccg ttatgaagat cgaaaccaaa ctttgaatct tcctggcccg 1957921 ttgtaatgta gtcatgcgta tgcgcttcta ctccgggcgt gatccgaaga agaacatcga 1957981 tggagtgacc cgtttcttta cataggtctt caagaagcgc gatttcatag aaattatcca 1958041 ccacaatgca gccgatgcgg tgctcaagcg ccatccgcag ttcttccctg ctcttattgt 1958101 ttccatgaaa gtggatgcgt tctgccggaa agcctgctgc aacagccgta tatagctctc 1958161 ctccggatac gacatctaaa gaaagtccct cttcctcagc gagctgaatc attgcgactg 1958221 atgagaatgc tttgctcgca tatgccacct gtgctttcag ccctgcagaa ataaacgcct 1958281 gcttaaagct tttagcacgc tcacgtatta aagccacatc atatacgtaa agaggtgtac 1958341 catatttctc cgctaaatag agagcatcca cacctccgat ttctaaatga ccatgttgat 1958401 tttgtctgct tgtgccgtgt aagaacaatg tcattccctc tttctccgct tatggatgaa 1958461 aggacagttt tatggactgt cccttcataa ttaagacata cattatcata ctcttcagtc 1958521 agtttcaatg cgattatgaa ttggtaggct gccttaagcg atttttgggg tgaacgatgc 1958581 tgggtcttac ttttgcgcca ggtttcgctg tgcggacaag aacctgccac agcgcctttc 1958641 cgttaaaggg aatcagcggc cataagtacg gtgtctgaag ggatttgatg cttgccatgg 1958701 caataattag cactgtaaat ccgatgacga gcccttttat atgaaataaa gcaacgagta 1958761 tcatgaggac aagacggctc attttgtttg ccaagcttaa ttcataacta ggcgtcgtaa 1958821 aggttccaat cgccgcaagt gagacgtaca gaatcacctc aggagaaaaa aggccgacct 1958881 caatcgcaat ctgcccgatc agaacagcgg caattaaacc cattgctgtc gataaagccg 1958941 tcggtgtgtg aatggcagcc attctgagaa actcgattcc taagtcagct aaaaatatct 1959001 gcaggatgat cgggatatgc gtatctttat ttaaaccgat aaatttcatg ttgtccggga 1959061 gcagatcagg ctgaagcaca aagagaaacc agatcggaag aaataaagta gaagcaagaa 1959121 taccgaaaaa tcttacccga gctcgtggtc attcggcata attacttaaa ttttgtccag 1959181 tctcccatcg tccgctttaa gaatgtgata aacccggctt tcttcatatc ttcttttgca 1959241 gcaacaggac tttcagcgag tacttctcca tcctttttca gaacaagagt gccaagctct 1959301 tggccttttt gaatcggagc actaatattg tccttcatct tgatttcttt tttcacatcg 1959361 ttcatatcct cgcctttttt cgtcaatatt gaaatcggct cagatgtagt gagttcgata 1959421 aatttttgtt tccctttttt gacctttact tttgctactg tttgatttcg tttatataaa 1959481 ggatgcgttt catattggct aaaggcgaag tcaagcattt ttgtcacttg cgcgtttctt 1959541 tctttaggcg tgctcgctcc gaatacaacc gctatggccc gcatgtttcc ttttttagcc 1959601 gaagcagtca gacaatattt cgcttcgcct gtatagcctg tttttacgcc gtctacacca 1959661 ggataaaatt tgataaggcg atttgtattt acaagccaaa actttttatc tgtattttca 1959721 cgcagataat cttcatacgt gccggtaaac ttcgtaattg attcgtattt caataattcc 1959781 ttagccatga ttgccatgtc ataagcagag ctgtagtgtc cttcctcggt cagtcctgtt 1959841 gggtttttaa aggatgtatt tttcaatccc agctcttttg cttttttatt cattttcttc 1959901 acaaattctt cttcagagcc ggaaataaat tcagccatgg cgacggaagc gtcatttccc 1959961 gaagcgattg cgatgccttt cagcatttct ttgacagtca tttcttcgcc gggctcaagg 1960021 aatatctgtg agccgcccat tgacgccgca tgctcgcttg tacggacctt atcactcatt 1960081 ttgattttgc ctttatctaa agcttccata atcaaaagca tcgtcataat tttcgtcatg 1960141 cttgcaggcg ccagtctctc attgctgttc ttgttgtaaa gcacttttcc cgtgtcacgt 1960201 tctatcagca ccgcagactt cgcttcatga gcaagctccg atgtacgttt tccgtcttgt 1960261 tttgcaaatg cagacggtgc aaatgtaagc agcattatac caatcaacaa agtggataaa 1960321 agacgtttca tctcaaaagc cctccatttc ataatccttt ttattttttc caagcgtgat 1960381 ggttttatac gccactgatg gaaaatgttt cgaattttgg gcataaaaaa agacagctgt 1960441 gtgatatcag acacagctgt cttttggtcc tgcattgatt catatttatt cgtactgagc 1960501 gacgatcgct ttaacaagct ttaagaatcc agcttttact ttttcggtca cttccataac 1960561 ttcatcgtga cttaaaggct gatccagaat tccggctgcc gcgttagaga tgcaggaaat 1960621 gccaagaacc cgcattcccg catgattcgc tacaatgact tccggaacag tagacatgcc 1960681 gactgcatca gagcccatcg ttcttaagaa acggacttct gccggtgttt cgtaagaagg 1960741 tcctgtcaca gcagtgtaca cgcctttttg aattgggata ttaaggtctt tcgcaatctt 1960801 ttcagccagg ctggacagat ctttgtcata ggctgaagac atatctggaa atctggcgcc 1960861 gaaatctgct tcgtttggcc cgattaacgg gtttgttccc ataaagttga tatgatcggt 1960921 aataatcatt aaatctcccg cacggaattc agtgttgaca ccgcctgcgg catttgtcac 1960981 gatcaacgct tccacaccga gcgctttcat cacgcgtaca gggaatgtga ctttctccat 1961041 tgagtagcct tcataaaaat gaaagcggcc ctgcattgca atgacggaaa ctccttcaag 1961101 agtgccaagc acaagctgtc cggcatgccc ttcaacagta gataccggga attcaggtat 1961161 atcttcatat ttcagcttga ccggattttc gatttcgtcc gccaaaatgc caagacctga 1961221 gcctaaaata aggccgatct ttggagattc cggcaggttt tgtttaataa aagcggctgc 1961281 gcgttcaatt ctgtccttca agaaacagtc cccctattgt aataaagata aaaagctttt 1961341 cccgtatttc ggtttatttg tttggaaatt atcagcgatc gttgcgccaa tatcggcaaa 1961401 tgtatctgca agcggcagca tttgcgcttt cttatgtttt ttgctgtaag cgagaatcgg 1961461 cacatactcg cgtgtatggt cagtcccatg atgaatcgga tcattgccgt ggtcggctgt 1961521 aataattaac agatcgtctt ctctcatttt ttcaaacact tccggaagcc gcgcatcaaa 1961581 ttcttcaagc gcgcgtccgt agccttcagg gtcacggcgg tgtccgaata acgcgtcaaa 1961641 atcaacaagg ttcgcaaagc tcagacccgt aaaatcttct cccagcgtat cgatcacctt 1961701 gtccattccg tccatattag aaaccgttct gcgtgaagaa gtaatgcctt ctccgtcgta 1961761 aatatcagag attttaccga ttgaaatcac atctaagccg cagtctttca attcattcat 1961821 gacagtgcgg tcaaacggct tcagcgcata atcatggcgg tttggcgtcc gtttgaattg 1961881 acccggctct ccgacgaacg gccgtgcaat aatgcggcca accatatatt tcggatcaag 1961941 cgtcagctct ctcgccgttt cgcaaatgcg atacagctcc tcaagcggca caacctcttc 1962001 gtgagcggca atttgcagaa cagagtcagc agacgtgtaa acaattaaag cccctgtctc 1962061 catgtgctcc tggccaagct catccaaaat cgctgtgccg gaagccggct tgtttccaat 1962121 aattttgcgg ccagatctct tttccagctc ttgaagcaat tcatcaggaa agccttccgg 1962181 gaacacttta aacggtttat caatgtataa acccataatc tcccaatggc cggtcatcgt 1962241 atctttgccg tttgacgctt cttgcatttt tccataatag gcaagcggat gttctgtttt 1962301 ttctacacct ttgatatctt cgataagacc aaggccgagc tttgccatat tcggcatatg 1962361 taatccgttc atatgctcgg caatatgacc gagcgtatga gcgccttcgt cattaaagtc 1962421 agcggcatcc ggcgcttcgc cgattccgac tgagtccatc acaattaaaa acacacgatt 1962481 atatttgtat gcaggcatct tgaaagcctc ctttttttct atacgtctat tgtatcgcta 1962541 agaggtctga caactcaagt ataaaccgtt ttcattcccg ttgacaatgt atttggaaat 1962601 aatgagaaac ttcaatattt tctgtcgctc taaacaaaaa agccgcagcc acctgcggct 1962661 atgctcgcgg atgaaactgc ttgtacacat ccttcagcct tgttttcgtc acatgcgtat 1962721 aaatttgcgt cgtggatata tccgcatgac cgagcatttc ctgcaccgct cttaaatctg 1962781 ccccgttctc aagcagatgc gtcgcaaagg aatgcctgag tgtatgcgga gtcagctctt 1962841 tcttaatgcc ggcttccaat gcgatttttt tcaggttctt ccaaaatccc tggcggctga 1962901 tctgtttgcc gtgatgattt aaaaagaggg cgtcagatac attatttttt aacagttttc 1962961 ccctggcttt tgtcatatat tcctcaatgg cggaagcagc ggcttcaccg attggcacaa 1963021 tccgttcttt tcttcctttg ccgaagcatc ggataaaccc catagataaa tgaacatcag 1963081 ccgttttcaa ttcaatcatt tcactgactc gtatgcctgt cgcataaagc agctccagca 1963141 ttgctttatc ccgatatccg aaagggctcg tcagcttagg cgtgtccaat aaccgctcga 1963201 cttcattgag cgcgagcacc ttcggaagcg cccgttccgt cttttgtgtt tcgatatgaa 1963261 cggaagggtc cttatccgtt actttttccc tgagcagaaa ttgatgaaaa gagcgaatgg 1963321 atgccaaatg ccgcgccgat gtcttgccgg atttccccga gtccttcaaa tgctttaagt 1963381 attggataat atgtatgcgg gtaacgtgat tccaatctgt aacatgaagg gtttctgtta 1963441 agtagagaga atagcttttc aagtcacgtt cataggatac gatcgtattt tgagagagcc 1963501 ctctctctac cataacgtag tggatgaaat cctttatttg atctttcact cttgatctac 1963561 tccccgtttt ggtaaaaaaa gatcaaccgg tcgaaccatc cgcctttttc atcctgatcc 1963621 atttcaacaa cttttacagc ggagccttcc ggtttatcat accgatgata gttttcatac 1963681 tcttgattca cccatatcat agcataatag aacaaagcgg taaaaccggt aaacaggatg 1963741 aaaactttca atgcatcgac agctgttttc aggaatcttc ccatgtccta atcgatcctt 1963801 tccctatggt tccagttata taaaccatat gccaaatcag aaaggtttta tacatagaaa 1963861 cagcaaaaaa ccctttcccc atgagaaaag gttcgcgctc ggcaccgtct attcagtttc 1963921 ttttccgtta cagcggtggc aaatgccgtg aaacgtcaat ctatgatctt taatcttaaa 1963981 tttccaatca cgttcaatga tttcttccac gtcttcaagc aaatcttctt caatttcatc 1964041 aacggctccg cactccatgc acaccaagtg gtgatgaaag tgagctgcgc cctctttccg 1964101 aaggtcgtaa cgggacacac cgtctccaaa gttaatttta tctacgactt ttaattcagt 1964161 taataattca agcgtacggt atactgtagc gagaccgatc tcaggagatt tctcttttac 1964221 gaggaggtat acatcttctg cgcttaaatg gtcttcttcg ttttcaagca gcactcttac 1964281 tgtcgcttca cgctgtggcg taagtttata gctggatgag tgcagttgtt tcttaatacg 1964341 atcaatacgg ttttccatgt ctttccctcc tacgccgcat tccatgactc attataacaa 1964401 aatacgcgca gagttccaac tataattatt ataaactgat aaataaaatg gttttctttt 1964461 aataatgatt ttaaaaaagt ctagatgtaa gcttttccat taaaacagga gataagtatg 1964521 cttcaaagag agatgaaatc agcgctaaaa acagaatgac cagcagcaca aaggcatacc 1964581 gcccgaacca ttgaatcggc gcgtcatgca ggcttcgttt cacgaacagc tgtctgatta 1964641 actttaaaga aaacgcaatt gcacatgtgc ccataatgag ataagccgga atcagcagca 1964701 cattttgcgg caaaacggag acaaatgata ggaaaaaccc gcttactccc atctgattga 1964761 ctaggaaccc gacagtaaag ccgacgacga tccctttcag aaagatcata atgaaaataa 1964821 tcggcatccc aatgacggaa attcccagta tccacatcag gcctaaatac tttgcattat 1964881 gaaagatact ttgcccaaac atatcagctg aacttgcctg ttttccatcc gaaagctgtc 1964941 caaaaaattg acttaagtag tagtataaat cttctttctg gctgatggtc atactgttga 1965001 caataatcgc gccaaagatg acacccatga aaaacagcac tgacacaaat atataaagag 1965061 agagatgatc tttgacatgc ctgagaaaca tgtccttata agagattttt cgcataccgt 1965121 ttcctcccgc ccgctctagt gatttgattt aatagattgt atgaaagaaa cagaaaaaca 1965181 tgcccttttt caaaaagaaa caatagagat gaatgctagg cggctttttg gggcacaaaa 1965241 aaatccttat catcaactgc tgtatgatca taaggattct tatgcttccg tttattcaaa 1965301 atctcttttt tgctttttgt cattcttcca tgtgtgctga aagatggtgt gctgcctctt 1965361 gataataaga cgtcacgtcc gccgtttctc aatcgatgcc cccgcttctt tttcgcttgg 1965421 ctttttgcca tgtgatcact ccctttttta ttttcatagt aatgataaca aaattgaaca 1965481 atgataagaa aaaaacagca cctgctacga caggtgctgt ttagctacat ttatttcact 1965541 gctgtaagag ctgcatgctc gacagctgct gctaccgcat gatggacttt tgaatcaagc 1965601 ggctgaggga caacatcacc ttgtttagtg caagctgcga tggcctctgc tgctgcgaca 1965661 agcatatcat gattaatctc cgtgcttttt gcgttaagcg ctcctctaaa aatccctgga 1965721 aaaccgagta cattattaac agaacgcccg tcagctgcat atgcggcgcc agcctgcagt 1965781 gcggcctccg gctcaatttc cggcttcgga ttcgataaag ccagaatcac ttgaccagaa 1965841 cgtacaaatg ccggttttat taaacccgga acgcccgttg tagcaatgac aatatcacat 1965901 gtttccataa gctcctcaat actggaaact gcctgtccgc cgtattgttc gagacggttc 1965961 attgctgact ctgatttgtc tgttccgtat acagcattca caccataagc catgaacatc 1966021 cggcagatgg ccacgcctgc tgcgccaagg ccgatttgcc ccactttcgc ttccttcagg 1966081 tcaacccccg cactcctgca tgccgaaatg gcagctgcca gcgtcactac agctgtacca 1966141 tgctggtcat cgtgcataac agggatgttc agctcctctt ttaggcgatc ctcgatttca 1966201 aaacaatgcg gcgaaccgat atcctcaaga aggatgccgc taaagcccgg agaaatatgt 1966261 tttactgttt tgatgatttc ttcaggatca ctcgtatcaa gcagtatcgg aatgccgcta 1966321 atacccgcca gctgatcaaa taaagcagcc tttccttcca tgacaggcat gccagccaca 1966381 gagccgatat tcccaaggcc taaaattgcg gttccatccg ttacaattgc aacagaattg 1966441 ctgatcgttg tataaataga agctttttca ggttcttttt cgatcagtcg gcacacgtcc 1966501 gcaacacctg gtgtgtagac acgtcccagc tctgccagtg aacggatcgg cattttgctt 1966561 ttcatttgga tttttccgcc ttcatgtgcg gacaggactt catcagatac ggtgtgaagc 1966621 ctgatccctt ctccgagggc ctgtacagcc gcgatcactt cctgaagctg ttcttcattc 1966681 tccacttgaa cggtaatatt ccgcattgtg taattgggtc cgacttttac cgtctccact 1966741 tcaccaatat ccccgcccag aaggccgatg gccgtagcca cccttccaag atttccggga 1966801 accgaaggcg tttcgatcat cagtgtccga atcatgtgtt tcgctatcat tcagtgatcc 1966861 tcccctatta gcctagtttt tcggctttaa ctgtattgtt tttcgtatac catataaatt 1966921 ttcctgtata accatagata attgcaagac ctattgctac aaaactgagc cacataaacg 1966981 gcagataaga gaaggtagaa acacctaaaa taccagccat gtaaatccca ttatcagacc 1967041 aaggaaccat ccccgaagtc aatgttcccc cgacctctga gttacgtgat aacactcttc 1967101 tgtccagatg taagcgatca tagctgtctt ccataatttt cggagtcaaa ataagagata 1967161 catacatcgc acagccgaag atgtttgcta aaaacgctac gatcagtgta gacaatgtga 1967221 cattgccggc tgaagttaat ttcttttcaa acgttgaaac aatgactttt aacacgccga 1967281 gtttctcaag cagaccgcca aaaccaaggc caaagatgat gacgacgaga gaatcaagca 1967341 taccgacaat tccaccgcgg tttaacaagc cgttcaaaaa ttcaacatcc gttttaatag 1967401 agaagccgtt gtacgcagtt gcaatcgcat gggcaatatc cattccttgg aaaacaacag 1967461 cccagattgc accgagtaaa gcgccaatta cgataactgg catagatggc tttttcatcg 1967521 ccaataagac tatgacgaga actgccggga tcagcatcca aatatgaatg tcaaacgtgt 1967581 tttgcaaaga tgattttaag aattcaactt tatcaagatc aatatttttc ccgccgtaca 1967641 taaatccaac aactgtaaag agtatagctg taatgacata agcaggtatt gataaataaa 1967701 gcattgctct cacgtgagcc aatacatcga cttttgatag tgaagaagct agaactgtac 1967761 tgtcagacag cggagacagc ttgtccccaa aataagcacc tgaaagaata gctcccgcta 1967821 ctagaggaag cggaatgcct aacccctctc caattgcgat catggcaatg ccggcagttc 1967881 cgactgttcc ccatgacgtt cctgttgcca cagacataat ggaacaaata attaacgttg 1967941 ccagtaaaaa gatacttggg tgaataaatt ccagtccgta ataaatcaaa gtcggcacaa 1968001 cgcctccggc aatccatgtt ccgatgagcg ccccaactga aacgagaatc agtacggctt 1968061 caaggccatt tgatatccca tgtacaatcg cattttgtaa atctttataa gaataaccga 1968121 gtctaatacc taaaagcatt gcaataaacc atgaaacaaa aagcgccagc tgtatcggca 1968181 agtcgagaaa gactgtaaac gatagaacaa gtgctaaaaa tactcctagt acaataataa 1968241 tttcaaatag tgttggcaat cttacatcct tcaaaagaag tcccccttca tgtaaaagct 1968301 aaaacgcttt caatatatag tgcaacacgt atactatact tcctcatccc tatgttgtaa 1968361 acagcttatt catccgacta ttcggagatg aataagctgt attttataca aattttattt 1968421 ttctaatagt tctttccctg cgatacctgg tttggtcatc tcatatgggt ttaaaataat 1968481 atccaattct tcttcagtca gcacatcatg ctgcagacaa agatcccgga cagattgccc 1968541 tgtcataatt gcttccctgg caattctagc tgccgcttca tacccaagat gcggattgac 1968601 agctgtgatc acgcctgcgc ttttttctac gtattgcttc atacgctttt cgttggcttc 1968661 aatgcctttt aagcagttgt cagtgaacga acggaagccg ttgttcatga tgctgatgga 1968721 ttgaagcaaa ttaaagacaa gcacgggctc catgacgttc aactcaagct ggccggcttc 1968781 tgaagcaagg cagattgtat tgtcatttcc gataacctgg aacgcaattt ggttgatcag 1968841 ctccgccata accggattga ctttccccgg cataatagat gaacccggct gacgtgcagg 1968901 cagagaaatt tccgcaagtc cggcgcgcgg tcccgacgcc attaagcgca ggtcgtttgc 1968961 gatcttcgac atgttcatca tgcagacttt taatgaagct gatacctctg tataggcatc 1969021 tgtattttgt gtcgcatcaa caagatgatc agcgccgaca agaggaagcc cgctaatatc 1969081 agcaaggtgc tttactacct gtttgatata ttcaggatca gcgttcagcc ctgtaccaac 1969141 agcagttgcg cccatgttga cttcatacag gtgctggcgc gattgcttga ttcgtttgat 1969201 atcacgctcg agaacacggc tgtaagcttc gaattcctgg ccaagacgga tcggaaccgc 1969261 atcttgaagg tgtgtccggc ccattttaat aacagagtca aactcctgtg ctttttgctt 1969321 aaacacacta tgcatatctt ccattgtttt cagcagtttt tctaagagct tcaatgtgga 1969381 aatatggata gcagtcggga acacatcgtt cgtagactgt gacatgttca catgtgtgtt 1969441 tggacttaaa tggatataat ctcccttttt atgtcccatg atttcaagcg cccggtttcc 1969501 gataacctca ttcgcgttca tgttcataga agttccggca ccgccctgaa tcggatcgac 1969561 gataaactga tcgtgccact tgccttccag aatctcgtca gcggcttgta cgatagcttg 1969621 gccaattcct tcatacagcc gtttcacgtc catgttggca agagccgcag cttttttcac 1969681 aatcgccagt gcgttaatca tttcctcatg gattttgtat cctgtgatcg gaaaattttc 1969741 agaagcacgg agcgtctgaa ttccgtaata aacatctgct tcaatttgtt tttccccaag 1969801 gaagtctttt tccacgcgat attctttttg gccgtttaac ataatcttta accttctttc 1969861 tctttgctgg ttatcgtttt tacattttac aggacaacgt catcagctat cggcgtttcc 1969921 ataattctct tgacgacagg aagatccgaa gactgaccta gcgcccacat caattttggc 1969981 acaattgctt ctgtgttcat atttcttgat cggataatta agtcttggtt gactctgcgg 1970041 ccaacctcgt aaatgctcat gtcttcgcct tcttcaagac attgagtcgt aatgacgacg 1970101 acaatgccgc tttcgatcag ttcattcact tttgacaaaa tgtctctgcc ttcaaacggc 1970161 actcctccgc tgccataact ctcaatgaca attcctttgt acatgctttt cagggcatca 1970221 aacatttcgg gctttaagcc tggatgcagc ttcagcagac atacatctgt gcatagtgaa 1970281 gtgtcaactg tgaaggtgtc gttctcaggt tccgttactt gtttgttgta ttcgatcccg 1970341 tcttcattga taaaagcgat atatgggtaa ttgatgcttt caaatgcgtc gtagcttttc 1970401 gttcttaatt tgatcgcacg cgttccctga atgactctgc cgtcaaacac aacataaacg 1970461 ccgcccacgc cttcacaggc aaatcgaatg gcatctgtaa tatttttttt ggcatcggtt 1970521 ttttggaacg tgatcggaat ctgcgagccg gtgatgacaa tcggcttttt ggcatgctgc 1970581 agcatatacg atagtgcggc agatgtatag gccattgtat ctgtaccgtg agtaataaca 1970641 aacccgtcat aggcatcata attttcctta acggcttctg ctatttccac ccagtattca 1970701 ggctgcatat tggtgctgtc tatattcata agcgactgag tttccattgt gtaatcgtta 1970761 tcaagttttg atacgtaact taataattca tcagccttga ctccgggagc cagcccattt 1970821 tccccttcaa ctgaagcaat cgttccccca gttgtcaaca tcaataattt tttcatacca 1970881 tgcacctctt cactgtatct aaagatgggt tgcgagaagg tattcgcttt tcgcatactt 1970941 ttaatgcaat tatagacacg gaaaataaaa tacgcaagac attattattc aattcgcgta 1971001 cacttcctaa tacctatatg atataatcag ctcaaggtga aaaaggagcg gaagttcatg 1971061 aatctagatc gtttaactga attgagaaaa aagaaaaatt ggtcgcttca atatacagct 1971121 gaccttctcg gtatcgcaaa aagcacatat gccggctacg agtcaggcta ccgacggcct 1971181 tcacttgaag cgcttgccat gctggctgac ctctttgaca caacctgcga tgaactttta 1971241 ggccgcgaga aacaaaagca gactgctcct caggccatag aattggccac gtggagcagc 1971301 ctcgacttta ccatttctgt tgatggccag ccgctgagtg aagatgaaat catccagctg 1971361 attaccttta tacgcacaaa aagaaaagta caggaggaac tgagttaatc tttagctcac 1971421 ggtttaattt taccgtaggt tcctcctcct ccggctttca attccagttt tccggatctc 1971481 gcttttacga taagcgccgc ggttttcggc gggacaacgc gagccaaatc ttcttctgca 1971541 gcctcatgaa gaacagccat ttctgttccg aaggcttttt ttagtttgtc cagcgttttc 1971601 gggcctacac ccggaacaaa ttgcagcggg atctgatgta catatcgcgg acgcgggacg 1971661 cgaacttcaa gctgatcact caattcacgc aatctatcgc tgactccctt ggtaaatctg 1971721 gcttttccgc aattcgcgca cgctgtttcc ccgcttacag caggctctcc gcacgcttcg 1971781 caagccgtct gataatattt ccccaataac gggtccaagc cataatttgc gataattttc 1971841 ctgtcatctt gtccctttaa tgcaagagca aattcagtaa aatcagctga ctgcacatat 1971901 aattcattat attctctgcc gattttcccc aacgaatgcg catcagaatt tgttaaaaaa 1971961 ggatacggat tcaattgcga tacgtgtgat gccatgtctg tatcacagct taatccaagc 1972021 tccaccgcgt ctatcataga tggatcaaaa acctcagtta agcttgattt aacccctttt 1972081 ccatataagc ttttatgcgg cgtaaagata tgggcgggga taaacaggcc gcccatatcc 1972141 tgcacttttt tttgcaggtt taagcccgtt tcataaatcc gctgcgagct taaatgaata 1972201 tttttcagcc gggctgacag ccagtttgaa aactgtttca tatcagccag cgtcggcata 1972261 aatacgagca catggatcgg tccgctgcag gcttcatcat aaatctccag ctcgctcccc 1972321 aataaaagag tcgtgctgcg ataacggatt cctcccccgt caagctcgcg atattttcca 1972381 gatgaaatgc cttcctcaag ctctagaatg acttccggag aatgacagtc gataatgccg 1972441 aggagttcaa ttcctttatg ttcactggct tcaaccaaaa ttctgtccag cgttaatgtt 1972501 ttggcgcctg ttattttgac agcccttcct gtaaaggtcc ggccgatatg aatgtgcaaa 1972561 tccgcgtaaa tctttttcat ttttgtgctt ggagcgcttc tttcagctga agatactgaa 1972621 tcgcgtaggc tgttttagca tcatatactt cacgcgattc aaccagcttt agcgcatctt 1972681 caagcgtcac ctccatcact tcaacaaact cgtcctcatc aagctcccgt ttttcttcaa 1972741 gcacagaaag ctcctcagca agaaaaacgt gaacgatttc atctgcaaat ccgggtgatg 1972801 tataaaacgc agttattttt gtcagttttt ttgctgtata accggtttcc tcttcaagtt 1972861 cccgaagtgc cgtatactcc ggctcctcac ctttttcaag cttaccggcc ggaatttcaa 1972921 cgatcgtccg ctcaagcggc ttacggaatt gtttgaccat gatgattttc ccttcatctg 1972981 tgacggctag taccgctaca gctccagggt gtttcacaat ttcacgttta ctggctttgc 1973041 cgtttggcag ctctacatcc tcgacataaa gatcaatgac tttacccgaa aaaatctgtt 1973101 ctttggcaat tgttttttct tctaatgatt tcatttcttc atctcccgtt ctgtctctat 1973161 atgatgcccc atacatttta tcatactaga gcaaaagggg gcttcttcgt gaaagtgcac 1973221 cgcatgccaa aaggtgttgt cttagtcgga aaagcatggg aaattcgagc gaagttaaaa 1973281 gagtatggac gcacatttca atatgtgaaa gattggatct caaagccata aaagttgaaa 1973341 ctttagctcc tttatattac ggtcaataca aagcctaaaa aaggagtgtg cacatgagaa 1973401 agcgcaaatt gggtacatct gatttagaca ttagcgaagt cggactcggc tgtatgtctc 1973461 ttggaactga aaaaaacaaa gcattgtcca ttctggatga agcgatcgag cttggcatca 1973521 actatttgga cacagcggat ttgtatgacc ggggacgcaa tgaagaaatt gtcggtgatg 1973581 cgatccaaaa cagacgccat gatattattc tggcaacaaa agcgggaaac cgttgggatg 1973641 acggaagcga gggctggtat tgggaccctt caaaagctta cataaaagag gcggtaaaaa 1973701 agagccttac acgtctgaaa acagattata tcgaccttta tcagctccac ggcggcacga 1973761 tagaggacaa cattgatgaa acgattgaag cgtttgagga attaaaacaa gaaggtgtca 1973821 tccgctacta cggcatttct tccatccgcc cgaatgtgat taaagaatat gtaaaaaaat 1973881 caaacatcgt cagcattatg atgcaattca gcctgtttga cagacgccct gaggaatggc 1973941 tcccgctttt agaggaacat caaatcagcg tagtcgccag aggtcctgtt gccaaagggc 1974001 tcttaactga aaaaccgctt gatcaagctt cagaaagtat gaaacaaaac gggtacttgt 1974061 cctattcatt cgaggaactg acaaatgccc gtaaggcaat ggaggaagtg gctcccgatc 1974121 tttccatgac agaaaagtcg ctgcagtatc tgctagcaca gccggctgtc gcttcagtga 1974181 ttacaggcgc cagtaagatt gagcagttac gggaaaatat tcaggcagca aatgcacggc 1974241 gtttaaccga agaggaaatc aaagcgctcc aatctcatac gaaacaagac atttacaaag 1974301 ctcatcgctc atagcagaaa aaccagcacc tgtacgggtg ctggtttatt tatattgatg 1974361 ccaatccatt tggctttcat ttaggagttc ttcaaagctc ttattttttt cgatctcttt 1974421 tttctttcta atctgttctg ctttttctct tttctgcctc ttttcatcct cttccttcaa 1974481 ttggctcttc atctccataa gctttgcttt gatatcggat tgaaggccgt cttttagctg 1974541 gtgtttgtca atggattttt gttttttcat gcagacttcc cccatgtttt gttttgaagc 1974601 cagtttatca cggagcatat aaactgaaca agcagactct cttctgatca ctttctcagc 1974661 gtagcagtgt ttaggtataa tgatcttaaa cacgaattgc ctatatattt cgttgaaagg 1974721 tgctgtgact tttgaagaaa atccttttgg ccattggcgc gctcgtaaca gctgtcatcg 1974781 caatcggaat tgttttttca catatgattc tattcatcaa gaaaaaaacg gatgaagaca 1974841 ttatcaaaag agagacagac aacggacatg atgtgtttga atcatttgaa caaatggaga 1974901 aaaccgcttt tgtgataccc tccgcttacg ggtacgacat aaaaggatac catgtcgcac 1974961 cgcatgacac accaaatacc atcatcatct gccacggggt gacgatgaat gtactgaatt 1975021 ctcttaagta tatgcattta tttctagatc tcggctggaa tgtgctcatt tatgaccatc 1975081 gccggcatgg ccaaagcggc ggaaagacga ccagctacgg gttttacgaa aaggatgatc 1975141 tcaataaggt tgtcagcttg ctcaaaaaca aaacaaatca tcgcggattg atcggaattc 1975201 atggtgagtc gatgggggcc gtgaccgccc tgctttatgc tggtgcacac tgcagcgatg 1975261 gcgctgattt ttatattgcc gattgtccgt tcgcatgttt tgatgaacag cttgcctatc 1975321 ggctgagagc ggaatacagg ctcccgtctt ggcccctgct tcctatcgcc gacttctttt 1975381 tgaagctgag gggaggctat cgcgcacgtg aagtatctcc gcttgctgtc attgataaaa 1975441 ttgaaaagcc ggtcctcttt attcacagta aggatgatga ctacattcct gtttcttcaa 1975501 ccgagcggct ttatgaaaag aaacgcggtc cgaaagcgct gtacattgcc gagaacggtg 1975561 aacacgccat gtcatatacc aaaaatcggc atacgtaccg aaaaacagtg caggagtttt 1975621 tagacaacat gaatgattca acagaataaa aaagcgaaag gcctcttcgg ctctttcgct 1975681 tttttatgtt acagaacgtc ggtaatgcca tccatatttt ctctgatcca ttcaatcgca 1975741 agatctatcg ttgtaaactc ctgcgtctcg aaggtcattt catcctgcaa tagccagaca 1975801 tctttcttga tggactctgc tcctccgatt gaccagtgaa gcaaggtata aggatggttt 1975861 tgattcagga aggataccca cgttttattt tgtgctgtgt tcttcattgc cttcagcttt 1975921 tgttccacgt ttcgcgtctc ctactttact aatatgctca ttctggggct gagcatttca 1975981 gccgggcttt tcagcgccaa tgttttggct ttttcattgt aatcgatcgt catttgatcg 1976041 tcaaaaaaca ctttttgcga cgattggata tacagcggaa tgccgttcgt ttccagctgc 1976101 tcgcactgtc ccgttaattc ttctgccagc cagattgtcg ggacaccgct taccgcgcag 1976161 ccgcatcctt ctgcatcgta acgaagctgg gctttttttc ccgggttggc gtcaaacgcc 1976221 tgctgcagtg cctgttttgc tgcatctgtc acatgtatgt tcataaggtg aaacccccgt 1976281 tttcatcatt ttcgctattg tagcatacaa tactgccatt cgcattgttt ctgccttttt 1976341 tccaccgctt cgcattttct tctgcagtct tgatccactc atctttccct tgtatatact 1976401 gattgatgct gtcagggtgc tgggccgcca gctgtttttt gagaacggcg tattctttcg 1976461 ctatgtttgg atgagctctg agataatctc tgaataacag atgcctttca atagcagggt 1976521 ttccctgttc gtacatatgg acatgatgag tgcgtttatt tccgcccttt tggaaataac 1976581 gcctgcccgc tataccgttc tcaccttttg gtgtatagcc gttggccttc atttgttcat 1976641 caaattggct cacggcttca atgcttctga cttcaattaa catatcaatg attggcttcg 1976701 ctgccatgtt aggtattgat gtgcttccga tgtgatgaat agcgataatc tccggcccga 1976761 acacaagttt cagccgttct ttttcttcat cgaaacattc tgcccatttt tcgttgtaga 1976821 gaatgatctc aacttttctt ttcggataca aatgaaagac cgacagcaat agaccctgcg 1976881 ctgctttgac ggtttctgcc ttttggaatc cggcctgtgt atagagtgac acagccgggg 1976941 tattgttctc ggctgtgact acttcgattt tctcagcgtc ttcattatga tcaatgacaa 1977001 attgcagaag cgctcgtcca attccttttc tgaaaccgtc aggatgcaca acaagcctgc 1977061 aaatggtgag ataatgcatg tttttctcat atgaaatgac accgatcagc ttgccgtttt 1977121 tccgatatcc cgcaaaccgt tcatgggatg cttgaatatc ctttaccttc tcttgtaaag 1977181 cgggaatacc gtcaaaaccg ataatctctg tttcctttat gtaggcgggg atctgtacgg 1977241 ctaaaatctc acgcgctata gtggcttcct tatgctggag aaattcaatc attcgtgttc 1977301 tcctgaaaca gccgctgtct gtcgactttt gcgacgcgga ctgcatacga ctcgtaccaa 1977361 acgcttcttc ctttttcttt tgctgcttga tgttcagtgt gatgcctcca atggttaatt 1977421 gcgtccatac tgtcccaata ggaaactgtg atgccccttc catccgcttc acgtacgctt 1977481 tccacgccta aaaatccagg ctgatccgcc gcaagtgata ccatccgctc cgctgtttct 1977541 ccatatcctg tgtcattttc gcttttgaca gaagaaaaaa tgactgcata gtaaggaggc 1977601 tcaggtgttt ttgataaaaa atccatcata tttccccctc atatgttttt gacaaatagt 1977661 accctgtctt ggcccgggcc atcatagttt gcaaacactg agatgccatt taccgttttg 1977721 gtgccctttt caatatcaaa ccccaatttt gtgtgatatg cgattgatac cttattcaca 1977781 ggtgaagtga cacacttcac ccgggtgcag cccctttgtt ttactgtttc gataaataca 1977841 tcatacaatt gtttcccaat ttgcattttt ctgaaatccg gatgcacacc ggaaaaatga 1977901 atgtacgccg tttcaggatc ggattgcgat tgaaatccga ttaaaaatcc cgtcatgctg 1977961 ttatgttcgg atgtaataaa gcttgtgtcc tgaaaatgct caaaaaatag tctcggcaat 1978021 ttttctttca gctgtctgcc gccccaccat tcattcagta cagacgttac catttcataa 1978081 tctgaagacg tgattgttcg aatatccatt acgatttgat ctccctccgt ctggcaaaac 1978141 gaatgtcagc tctttttctc acaatataaa aattatattt tgcctggctg gaattgtaaa 1978201 tgccttcttt cctgtatcat acgtttccag actgccgagg gaacaatgtt tgatcatttt 1978261 acgcctattt ctcccccaaa caggaggaga gactttacag cacaatatca agcacttgat 1978321 caagtttcag cttataaagc tgatcctcgt ctccttttat ccatactgct ttttcaaact 1978381 cttcataccg gcagattttc ccggtgcagc agacaatctc accgtcctga aagcagctga 1978441 cagtgatatc ctgagcaaac tccatcgcgg cgcaaagcgt ttgattcatc tcttccagct 1978501 tatcggggtc aaggatcggc ttttgcagct tctgtttaag tcgctttctc tccagcaggc 1978561 tttgcttatg ttccggcaga aacatcctgc tcccttccca cagcaggttg ccccttttta 1978621 aatggtcgtt catttataat gcccccctat tttagccgca cgttcaaatg cctggcctgc 1978681 cgctgtcagt gacgccgccc tgatgattgc tgtatcgccg aatcgatttt taatgccatc 1978741 catcacatag cctaggctca ttttctttgc ataatcctga aataaattga gctgccatat 1978801 gtcatcagat gagagctgag acagattgac accgaggcgg cggacgggtt tcccgtccca 1978861 aaatgtaaga aacagccgtc gtacagcctc atatacatcc tgcgtagaat tagtcggctc 1978921 tgccagcttc acttgccggt tgaagcccgt cggccaatca aaatcagcac cccggcagct 1978981 cactgacact gtctgcccca tgaccccggc gtttcggctt cgcctgcaca cctcttcact 1979041 cagctcaagc aatacgacct tgatttcttt gtcaaagtgt tcgtagtctc tcgggagagt 1979101 cattccatga cctatcgcct tttgcccgtc cagagacgaa gttgacacag gggaatagtc 1979161 gattccgttt gccgtcatcc acagcacgtg gccgttaatg ccccatttct tttttaaaag 1979221 atcgagcgga aaagccgcga gcccgccgat cgtgctgatg cccattcgat ttaaatgatg 1979281 cttcatgcgg ctcccgacgc caaacatgct gcccaccggg agcggccaca tttcggtttt 1979341 catattttct ttcgttaagg taaaaatacc gttcttattc tttttggcaa aattgtcaca 1979401 cgcaattttg gccagcgctt tgttagggcc gattccgacc cgtgcataaa cgccgatctc 1979461 ccgcatgatt ctgccctgaa tgcttttcgc gatctccatc ggcgtcccaa acagcttctg 1979521 gctgcctgta atgtccatga actgttcatc gatggaatac ggctccacaa ggtctgtata 1979581 ctcctcgaga atggccgtaa tttgcagtga tacatcaata taccgctgca tacgcggccg 1979641 gagcacaaca gcctcaggac acttttcctg cgcctcccac agccgtgaag cattcaccac 1979701 acccttttgt ttcgccagcg ggcaggcagc caatacgact ccgccccttt tttcagggtc 1979761 acccgaaaca atgacgggcc tatttttcaa atgtggattt tccgctttct ctacagatgc 1979821 ataaaacgat tgcatgtcaa cgagaaaaat cactttttct ttcatcatac acacctctaa 1979881 aaagaactta tgttcgcttt tcattatatg cgaaagtatg ttcgttttat actggtaaat 1979941 gattcttgtc tgacagaaaa tatgatccaa gggtttgaga gaagaaaaac atttagtaga 1980001 ataaaagcga agcataagga taggagagtc atgatggaga aatttgtcga aaaaatgctg 1980061 ggacaggcat tgcggcaata cggcagaaac gttgctatag atccgttaag cccgtatgaa 1980121 aaacaaagcc tgaaagcggc tctacaagag agacggaatg aagaaccaga tgaggatttg 1980181 catgcgcata tagaagatat catttatgac tatgtcacaa accaaggcct gttctcttaa 1980241 acgcatgact gtcagttctt tcagccgctg atgcggcttc cctttgaaaa caccgcctga 1980301 aacaaataaa cagtctcagg cttacagaaa aaaagcagga ttttctcacg ctccatagat 1980361 tcatatggcc tggcgtaaaa ttcccctcaa tgctcgcgca aaacggaata agctgtccat 1980421 gatcacgcgt atacactttt tcgaagagat gtgctctctt gttctgtcat gcggtccatg 1980481 ccggttttca gcgtacatct tgatctcata gccggtttca ctgccgatat gatccacgtt 1980541 ctggcggctt aaactaacac accctcactg accaatcgct ttgcttttca tcggacatcc 1980601 cgtcattttc cttctttcaa gatgtaaact ccgtcagcca cacgcatcct caacgcatag 1980661 tatattgcca tccatacaat caggcatact acatgtcaat aacgaaatat tttgaacgat 1980721 ctattggaga aggaaatttt ttcatatatg atagagaaag atcatacata caggagagaa 1980781 tataattcat gaagaaatgg aaagatatcc acccgatcag ctggacaatt ataatcggaa 1980841 ccattttcgg cagaatggca acatcgatga gcattccttt tttagcgatt tatttgacag 1980901 ccgtccaagg cgcatcagct tcctatgcag ggctggtcat cgccgcgagc tcatcagtcg 1980961 gcatcctcgc aagcttttac ggcggatata tctcagataa attcggcaga aaaaacatga 1981021 tgcttgtatc gattttcgga tggatgctgg tatttgcagg ctttgcggca gcatctaatc 1981081 tctgggtgtt ttttgtagta aacgcattaa acggtctttg caaatcactg tttgagcccg 1981141 cttcaaaggc cttgttgtct gatatgacag aagaaaaaac gagactgcta gtttttaatt 1981201 tacgctatgc ggctattaat atcggcgttg tcttcggacc tgtgcttggc ctatatttcg 1981261 gctcatcgca atcgactacg ccctttttgg tgcctgcagt catttacgga ctatacggaa 1981321 ttgtgcttgc cctccaattt aaaaaacatc catccttatc agcaccagcc cagtcccgaa 1981381 atatgagcgt gcgggaagcg tttatggtca cgcaaaagga ttatcttttt accattgctt 1981441 tggtcggcat tacgctatgc accttcggct actcacaatt cagttccaca ttccctcagt 1981501 atatggcgca gaaccccttg atcggcaatg gaacgaagct gtatgggctg atgctgacat 1981561 taaacgcaat cgttgtgttg gcgacgcaat ttcccattgt ccattttgca aaacggtttt 1981621 cgccgctttg ttctctgatg ctcggtaatg tgatggttag catcagcatg gccattttca 1981681 ccgtatcaca cggtgttcca tcaattgtga tgattgtcat cacatttaca atcggcgaag 1981741 tgcttttatt ctctatgatg gatttgtatg tagaccagat tgcaaaacca ggattaaaag 1981801 gcacttattt cggggcaatc ggtttttcac agctcggaaa cgtcatcggc ccttgggtcg 1981861 gggggatatg tatagacctg tttggcgctg gccggccgat ttatattttt tctgtcctga 1981921 gcggcattac cctgctcggc ctgccatttt tagcgttcgc ctatcggcaa atgaaaatgg 1981981 agaccacaaa acaccgttcc cgtctggaaa agccgcttta aataaaaaac ggaagagaat 1982041 gaatctctcc cgcaaacatg aggtgaagaa catgaatata ggtgatgtga tgtttcagct 1982101 gtttgtattt attatatttg ccgctgtcgt ctttgcggct gttacaggct tcaagtatgc 1982161 gaaaaaccga aaagcgcagc tggatcgcat tgagaaaaag ctgaacagcc tgtccgaaga 1982221 tcacgattaa cagcttgggg caacgagctc taccttaatc cggtctggat cctcacaaaa 1982281 gactgcataa tgcccgtctc ctccggcaaa aggatgcctg tctcggtaca acacacgata 1982341 gccttttgcc gtcaattttt cagtcatctg atcgacttga agcttggatt cagcatgaaa 1982401 tgcgagatgg ttcagaccga ctcggcatct atggtattcc ggctctagaa atggctcttt 1982461 cgcctgcaca atcactaggt aaaaacgatc tttcttccag ctgatgcctg agctccattt 1982521 ttgatactct ttataaccaa gttcttttaa gaaccagccc caaaaccgcc tagacgcctc 1982581 caaatcagag acatacagtt caatatgatg cacatttcat accctcctta ccaacacttc 1982641 ctcgacctta tgcccgtctc ccttacgcaa aatgagatct gacctgaatt tagttggcaa 1982701 aatattttca tataaattcg gccggttgac actctcccaa atcgaggctg ccatctcgtc 1982761 agcctcctga tcggacaagt ctttaaattt atgaaaatat gaatcaggat tttgaaaagc 1982821 tgtttcccga agcaggcgaa aacgctctaa ataccaagtg aaaatccggc tttcctccgc 1982881 atccacataa atcgaaaaat caaagaaatc ggaaacaaaa atacgcgggt tttcccggtc 1982941 atcctccaag gtgggcgact gaagaacatt aatgccttca ataatcacaa tatccgcctg 1983001 ttctacaacc tcgaacacac cttcctcgcg gtcataggtt agatgggaat acaccggggc 1983061 ctttacgctg tcctttcctg attttaagtc attcaaaaat tcgagcagcg cctttacatc 1983121 atagctttca ggaaatcctt ttcttgacat catatttttc tttttcagct cggcagtagg 1983181 aaataaaaaa ccatctgtcg tgataaggct cacttttgga cggtcaggca aacgcgaaag 1983241 cagcttctgc aagatccgcg ccgtcgtgct ttttccgact gcgacactgc cggcaatgcc 1983301 gataataaac ggaattttgg ctgaatgtgg gtgcttcaaa aaaacattga catgcttatt 1983361 gcgttcagcc gcagacttga catgtaaatg aagcaagcga acaagcggaa tatagatcgt 1983421 ctccacttct tcaacagata gataatcatt caatccttcc acagcttttg cctcttcttc 1983481 agatacagca atcgacaaat gccccccaaa accagaccaa gactcccgat tgtgctgtgt 1983541 atataaagta tgtaggttaa gttctttatt tttcactgtt tacacctgac tctctgtagg 1983601 ttaaaaccct tacaaagatt gtaacggaaa accttttcac tgtctgctta tttttcattt 1983661 cgttttttta gcaaatcagc accgattcgg ttatacgcag ccatttcatc ttttggaacc 1983721 atgcttcctc ccgttcccca gacgacatgt acggcatgtt ccatcttata tttctgagca 1983781 tagcgccttc cctcttctgt cgaaaaaagc tgaaccggcc cgaacatgcc agcaagagca 1983841 gagggctcta aatatttatc ttcagataca gccagcatat gaagcaaagt ataaagcgta 1983901 ttgtcctcta ccgtataaca gccgctcaga agcggttcaa tcagcttgcc gacaaatcct 1983961 gacggcctcc ctacggcaag tccgtcagca gccgtctgat tatccaggcc gatatcctgg 1984021 acggagatct tctcgtgaag tcctgaataa agccctaaca gcatacaagg tgaatgagtt 1984081 ggttctgcga aaaacacatg aacatcatct ccgtataaaa gcttcagccc aaatgctaca 1984141 ccgcccggtc ctccgccgac tccgcacggc agatacacaa acaagggcgt ctcaagactt 1984201 ggctttatat tcatacagtc aagctgtgtt tttaatcggc ttgcagcaac agcatatcct 1984261 aagaacagct gacgagaatg ttcatcatca ataaaataac agaatggatc ttgttccgcc 1984321 tgccgtctcc cttcgttcac cgcttcactg taatctgttt cgtactccat aacagtgact 1984381 cccttttggc ggaggagatc ctttttccac tgcttagcat cggcggacat atgcactgtc 1984441 acgcgaaacc cgagtgccgc gccgatgatg ccgatgctta aacctagatt tcctgtcgaa 1984501 ccgacagcaa tcgaatagcg ggagaaaaac ccggtaaacc gctcttcctg taagatgcgg 1984561 taatcatcgg tttcctgaag cattccttct tgaagcgcga gattttcagc atactttaac 1984621 acttcataaa tcccgcccct cgctttaatc gatcctgaaa tcggaagctc atggtcgcac 1984681 tttaaaagcc atcttccggg aaatggctgc tgatatgccg cttccagctt tcccttcata 1984741 tgctgcacct caaaaagcgg agactcgatg attcctttag cgcctttcgt ctcaggaaac 1984801 acctcggcaa tgtaaggtgc aaaccgctgc attctttttt ccgcttccgc tatctcggtt 1984861 gcccactcat ctgcacgggg taatggcccc tctttcttgc ctgaatttgc ccagaataca 1984921 ggctctgcat caatcagttt ctgaataaac ggatctttaa gcagagcatg aaggacttct 1984981 gaatgaactg acattcaaca atctctccct tccactatca aaaactgccc cgtgagaaac 1985041 aagccactcc accacaggca gttctatcat tattttttca tgagcgcgcg tcctgccagc 1985101 ttttctacaa gagctggaaa cagctgatac agcttagtgc cggcattcat taaacgcgga 1985161 agattgatct cccgcttttt cgtaaaaatt gcagctgtaa tttgagctgc cacgtcatca 1985221 ggatcaagca tccagcggcc gacatttttg gcgtagtccc cgcctttatc agcaatggaa 1985281 aaaaagtccg tctgaatcgg gcccgggttg actgttgtca cataaatgcc ggttcccgaa 1985341 agctccatcc gcaaagcgtt tgagtaacct aacacggcat gtttggtcgc ggaatacagg 1985401 ctagacttcg gtgtggcgat tttccccgct tgagaggcga tattgatgat atgtcccttt 1985461 ttttgctcaa gcatttgcgg aagcaccgct tttgtacagg cgatcaggcc gaagacattc 1985521 acatcaaaca tcgctttcat gtcatccaat gtagagtcta aaaccgtttc aaatataccg 1985581 aagcctgcat tgttaatcag tacatcaatc gagccgatct gatcgcggac ccgggcgata 1985641 tcctctaggc ggccgacatc cagaggaaaa atctcacact gtccgctcca ttcctcggtt 1985701 attttccttt tgatttctat caaacgatcc tcgcgtctag ccgacagcag gacatgggct 1985761 ccttcagccg cgcataagta tgcgattctt tctccaagcc ctcctgaagc gccggttatc 1985821 caaatccttt ttcccgctat atgtttcacc catttcacct cttcattgtt ttaaagtata 1985881 cggtatttcc ttcccaatat gacgtgatgg cttcttcagc ctccaacaca tcaaggtgac 1985941 ctgccgtttc tgacatcgtt aaaaacaatt ccttttcata tacagcagga aaaagctgct 1986001 gacagacctg aaaagcggtc atcggctttt catccagcat gcgacgcaca tcctccgtcc 1986061 tgttcctctg cttgtcaaaa cgcttctcaa tcagcgcttg tacactggtg ataggctcgc 1986121 cgtgaccagg aaatacgatt gttggatcaa gttgagacag ccttcgcaat gaccgctgat 1986181 aatccactaa aggctttgac ctgacgtctc ccgctttcgg cgcttccaaa atcggattag 1986241 acgagctgtt tgccagcagt agatcgccgc caagcatcct tccgcttttt tcatggaaca 1986301 gaacaatatg cgattcagca tgtccaggca tctccaacac agaccagccc tcaagcccat 1986361 ctatgcccat accttctctg attgattttg tcagagatct cgtacaggaa aatgcgtacg 1986421 ctgatcgaat cagcttttcc gccttccccg tatcaaatgg aacgcctaat tcaggcagca 1986481 gcttttgaaa aaaacgtttt tgccaatcca taaaggcttg attttggctg atataaggtt 1986541 cgttgaatgt atgcccaatc acttcgattt catctgaaaa gacatcaagc aagcctgcat 1986601 gatcagcatg atggtgagtc agtacaacct gctcgatatc tgacaatttc acatttacag 1986661 cggcaagctg ctcttgtaag gctctggcag cctcttttgt attcggcccg gcatcgataa 1986721 gtgtcagcgc atcacctttt acgaggtaaa cgataacatc gccgacagca aacggtgtcg 1986781 ggacgcggat cgcaattaca tcttcagttg tcatcctttc gctccttgtc ttcattcatt 1986841 attcatattt tagctttttc tcggtcttgt gtcattattg cagaatgaga acaaaccttt 1986901 ttgaaaaagc tattgacatt agcttgtccg ccattgcata atgaacaaca aactaaaacg 1986961 agaaccattg gaacgctatg acgaggaata gtatacaagg caatggccta agagagcgat 1987021 acccccggct gaaaggtgtt gcggcccgct tgtttgtaga acctgccctc aagtcgcggt 1987081 taggaaaacc taaacgtttc ccgcgttacg gggatttgag ctgagcacaa tttgtgctaa 1987141 tgagggtggt accgcgaacc ttttcgtcct ttacgtgatg aaaaggtttt ttgttgttct 1987201 aatagaagga ggatatcaat gaaaaagata ggatttgtcg gcgccgggtc aatggcagaa 1987261 gcaatgatca acggcatttt gcaaagcggc atcacaaaac cagaacatat ctatattaca 1987321 aatcgctcaa atgacgagcg tctgattgaa ttaaaggaaa cgtacagcgt gcgtccatgc 1987381 agagataaaa atgagttttt cactcacacc gatatcatta tcctcgcttt caaaccgaaa 1987441 gacgcggcgg aaagcatcga cagcatccgg ccgtatatca aggaccagct tgtcatttca 1987501 gtacttgcag gccttaccat cgaaaccatt cagcattatt ttggcagaaa gctcgcggtc 1987561 attcgcgtca tgcctaatac atcagcggca atcagaaaat cagcaaccgg attttccgta 1987621 agcacggaag caagcaagaa tgatattatt gccgcaaaag ctctattgga aacaatcggt 1987681 gatgcaacac tggttgagga gcggcatctt gacgctgtca ctgcaatcgc aggcagcggc 1987741 ccggcctatg tgtatcgtta tattgaggcg atggaaaaag cagcacaaaa agtaggatta 1987801 gataaagaaa cggcaaaagc actcattttg cagacaatgg caggggcaac agatatgctc 1987861 ctccaaagcg gcaaacagcc ggaaaagctg cgtaaagaaa tcaccagtcc tgggggcact 1987921 acagaggcag gtcttcgcgc tttacaggac tcccgctttg aagaagcaat tattcactgt 1987981 attgaagaaa cagctaaacg gagcgcagaa atcaaagaac agtttgccgg tgccgcctta 1988041 gagagacatt cttagatgta aggacaaaaa cagaaggcac agtgccttct gttttttatt 1988101 tttcccgcag cagctggccg gcagattctg attgctttaa tagcgcggag atcgtaaatg 1988161 aaagcaaatc gggaagcact tcaaaggaat aaggcatata caatctttcc gtccatttat 1988221 gcgggtcttt accagccgga ccgacattta aaactgggac atataaagcc tgatttttac 1988281 cgcttggcaa tgaataccct ctgttaaaga gcggcatatt gcttgtgtat gcatcaacct 1988341 cctgtttttc cagctgaaga taactcaagt ccgaaagtcc ggggaagtac tgaacctccc 1988401 gtaatgcaat gccgtatcgc tcagccgcat aatgctttat ctgatctgct gtatttctga 1988461 tcaattgatc atcctttgaa gaaacagctg gataaagcgg cggactataa aacagaacga 1988521 tgagcggcgc atcctcctta caaagcgaag caagctcaga aacaattttc gtcgaaaaat 1988581 ccctgtctcc aagctccccc ctgttagcaa aggcataatt tagagcccgc tctgtttccg 1988641 agatccccgc acgctttttt gcacgcgaga ccagctcatc aaatgtcaaa acagtgacgt 1988701 cccgctcaat cggctgaaat ggctcaaatt gttgaaaatc ctgtgttttc ttccgaacgt 1988761 tcgacatgat ttcctccgcc gcctgttctg ctgttttaag cagcatctga tgcagctcac 1988821 tagctgagcg tttcattgac agcacattaa ataatgtgac ggctgtatgc ggtgtctgga 1988881 ctgaatatgc ctctttcaag tccttttgca ttaagtttac cggcggcgga gtgacctcgc 1988941 catcaacctt ttcgcaataa tcagcattca gttcaagcaa acggttaatc tcagatacca 1989001 ttaaatttgc gtttagacct gaaaacggct ctccaacatg tgtctcaatc cccttgcaga 1989061 aaaaacccgc aagcaccttg ccaatgcttc ctgtataaaa atattgctgc tgatcgccgg 1989121 gaaatttttc aaacatcggt tcggcattca ggcaagcggt taatgtgata tcatgctttt 1989181 tctccatctc cttcaatgca ggaaccgctt caatcatgcc tcttgaattc acttcctcgt 1989241 ccggaaccgt tatcaacagc agattgccct caaaatgccc gttcattgcc ctctccagca 1989301 tcgacagttg aatacaaagc cccgctttca tatccatcgt ccctcttccg aacagccagt 1989361 ctccgctttc ggcatctctt ctcacacgtt ccgggagcag ctcttttttc tctaaaaagg 1989421 agctcaaaag ctcagcaggc ttgcaagcca tatgtttaaa ttcgccgtaa tcttctatgt 1989481 caacgacatc aaaatgactc agcagaagca ctgtcttttt gacattcttc tttttgacta 1989541 gagccgtaag aaaagatctg ccatcgtcca tcggatgaag tgttacatca tcagggtgct 1989601 tttgaaaata gggcttgtcc ttcaaaataa aataaagata ctctgcaagc gctacctcgc 1989661 cctttgaacc ggtgatgctt tcgtattgca caagagaagt taaaagtgcc agcaattcgt 1989721 ccttcgtctg ccaattcatt gattccgccc ctcctatgaa taaaaatgct tctatactga 1989781 aaaataaact gatttctcgt ctattataca gaaatgtttg acaaaagcgg ttcatttgag 1989841 cagtttatat gacgggaaag aaatgacttg atataatcaa tctctaaaaa ccttacggga 1989901 ggcgaaagaa atggccagaa aattatttac acctattaca attaaagata tgacgttaaa 1989961 aaaccgcatt gtcatgtcgc caatgtgcat gtattcttct catgaaaagg acggaaaatt 1990021 aacaccgttc cacatggcac attacatatc gcgcgcaatc ggccaggtcg gactgattat 1990081 tgtagaggcg tcagcggtta accctcaagg acgaatcact gaccaagact taggcatttg 1990141 gagcgacgag catattgaag gctttgcaaa actgactgag caggtcaaag aacaaggttc 1990201 aaaaatcggc attcagcttg cccatgccgg acgtaaagct gagcttgaag gagatatctt 1990261 cgctccatcg gcgattgcgt ttgacgaaca atcagcaaca cctgtagaaa tgtcagcaga 1990321 aaaagtaaaa gaaacggtcc aggagttcaa gcaagcggct gcccgcgcaa aagaagccgg 1990381 ctttgatgtg attgaaattc atgcggcgca cggatattta attcatgaat ttttgtctcc 1990441 gctttccaac catcgaacag atgaatatgg cggctcacct gaaaaccgct atcgtttctt 1990501 gagagagatc attgatgaag tcaaacaagt atgggacggt cctttatttg tccgtgtatc 1990561 tgcttctgac tacactgata aaggcttaga cattgccgat cacatcggtt ttgcaaaatg 1990621 gatgaaggag cagggtgttg acttaattga ctgcagctca ggcgcccttg ttcacgcaga 1990681 cattaacgta ttccctggct atcaggtcag cttcgctgag aaaatccgtg aacaggcgga 1990741 catggctact ggtgccgtcg gcatgattac agacggttca atggctgaag aaattctgca 1990801 aaacggacgt gccgacctca tctttatcgg cagagagctt ttgcgggatc cattttttgc 1990861 aagaactgct gcgaaacagc tcaatacaga gattccggcc cctgttcaat acgaaagagg 1990921 ctggtaatgc ccataagaga tatcctgtag aggatatctc tttttttatt tttagagaaa 1990981 cgatcggcta aggttctccg tctccctagt agaaccaatt agaggagatg actccaatga 1991041 aatcagcttg gatggaaaag acatatacaa ttgacggatg tgcgtttcat acacagcacc 1991101 ggaaaggatc aagcggtgta acgattgtct ttgaggccgg ctatggtact tcttctgaga 1991161 cgtggaaacc attaatggcg gacattgatg atgaatttgg cattttcaca tatgatcggg 1991221 caggcatagg aaaaagcggg caaagcagag ctaaacgaac agctgatcaa caagtgaaag 1991281 aattggagag tttgcttaaa gcagctgatg taaaacctcc ttatttggct gtttcacact 1991341 catacggagc tgtcatcacc ggtttatggg cctgcaaaaa caagcatgat attatcggca 1991401 tggtccttct tgacccagct ttaggcgatt gcgccagctt tacctttata cccgaagaaa 1991461 tgcacaaatc acatacgaga aagatgatgc ttgagggcac acatgcagag ttttcaaaaa 1991521 gtctgcagga gctcaaaaag cggcaagtcc acttaggaaa catgcctctt cttgtgttgt 1991581 catcaggaga acggactgag aaattcgctg ctgaacagga gtggcaaaac ttgcacagca 1991641 gcatattgtc tctatctaac caaagcggct ggattcaagc taaaaacagc tcccacaaca 1991701 tccatcatga tgaacctcat atcgttcact tggctattta tgacgtatgg tgcgcagcgt 1991761 gccagcaggc cgctcctctt taccaggcag tcaattaacg taaaaaaaga ccgggccgta 1991821 agggattccc ggtcttttat attattttgt ttcacggtga agggtatatt tctttaaacg 1991881 cggtgaatat tttttcagct ccaaacggtc tggattggtg cgtttatttt ttgttgtgat 1991941 gtaatttcgg tctcccgttt cagtgcaaag ctaaagtaac atttactctc ataattaaca 1992001 tctccttata aaacgtaatg attacgtttt attatacaac gtcatcacaa attgtcaaat 1992061 aagagctccg ccttcagcct cgcgggacgt ttacctctaa gaaatcatat gccgccacgc 1992121 tattggggaa aacgtcaacc gcttcttttt gaagctccaa agaagcatct ccctgatatc 1992181 ttgcgctgat atgggttaaa atgagctgct tcgctcttgc ttctttcgct gttacagccg 1992241 cttgttccgt tgtactgtga taataatcat aagcaagttt acggtcttcc ttagcaaagg 1992301 ttgcttcatg aacaagcaca tcacaatccc tcgcaagctc ttttagtttg tcacttactc 1992361 tcgtatcacc ggagaacaca acagatcttc cctttttagg aggctccaga aaatcattcc 1992421 cattgatgat tcgtccgtct tcaagcgtta ccgtttcgcc ttttttgatt ttctgatata 1992481 caggtccggg cgggatgttc atttctttta atacgtcagc cttcaaggaa cccggtacgt 1992541 ctttttcctg cacacggtac ccgaaggctt ccactccatg aataacagat accgctgtga 1992601 caataaactg atcgtcctca aacacgattc cttcttcaat ttcctggatc gcaagcggat 1992661 atgtcaaatg ggttttcgtg acggcaaggc ttgtttcaat aaacgccttg atccctttag 1992721 gtccgtacac tgtcagctcg tcctctccgc cttgaaagga acggctcccc agaagccccg 1992781 gaagtccgta tacatgatcg ccgtgcatgt gtgtaataaa gattttctct attttacgag 1992841 gtttaatcgt tgtatgtaaa atttgatgct gtgtggcttc cccgcagtca aaaagccata 1992901 ccgaacgcct ttcttcaagc aattttaatg ccaccgacgt tacatttctc gccttggcgg 1992961 ggatgccggc tcccgtccct aaaaaaagta attccacgtt tccttcctcc tactagaacc 1993021 agatacctac aagaatacag gatcaagcgg aaaatgtgaa tcttgcctct gaaaagaaca 1993081 atcctttcgt gctagaaaca ttttttcagc attctgctta aaaaagggct taaatgtttg 1993141 ctttcgttga attttagatt taaaatgaag gaaatatacg gggtgtacta aaataaagct 1993201 tcgaataaag tgaggtactt ttagtgaaaa caaaccaaca accaaaagca gtaattgtca 1993261 tattcggtgc aactggagat ttagcaaaac gaaaattgta tccgtctatt caccgtttat 1993321 atcaaaacgg acaaatcgga gaagagtttg cagtggtagg agttggaaga agaccttggt 1993381 ctaatgagga tcttcgccaa actgttaaaa catccatttc ctcatctgca gataagcata 1993441 tagatgattt cacgtctcat ttttactatc acccgtttga cgtgacaaac cctggttctt 1993501 atcaagagct aaacgtattg cttaaccagc tggaagatac atatcaaatt cctaacaaca 1993561 gaatgttcta cttggcaatg gctcctgaat tcttcggaac gattgcaaaa acattaaaat 1993621 cagagggtgt aacagctaca accggctggt cccgccttgt catcgaaaaa ccgttcggcc 1993681 atgatctgcc aagcgcacag gcattgaata aagaaatccg cgaagcattt acggaagatc 1993741 aaatttacag aatcgaccat tatctaggca aacaaatggt tcagaacatt gaagtgattc 1993801 gatttgccaa tgcgattttc gaaccgcttt ggacaaaccg ctacatttca aacattcaaa 1993861 tcacatctag cgaatcacta ggcgttgaag accgcgcaag atattacgaa aaatcaggcg 1993921 cccttcgcga catggtgcaa aaccatatta tgcagatggt tgcccttctt gcaatggagc 1993981 cgcctatcaa attgaacaca gaagaaatcc gcagcgagaa agtgaaggtg ctgagagcac 1994041 tgcgtcctat tgcaaaagac gaagtggatg aatactttgt gcgcggacaa tatcatgctg 1994101 gtgaaattga cggtgtaccg gttcctgctt atacagatga agataatgtc gctcctgact 1994161 ccaatacaga aacctttgtt gccggcaagc tcttgatcga caacttcaga tgggctggtg 1994221 ttccattcta catcagaacc ggaaaacgaa tgaaagaaaa gtccacaaaa attgtcgttc 1994281 aatttaagga cattccgatg aacctgtact acggtaatga aaacaacatg aatccgaact 1994341 tgcttgtcat tcatattcag cctgacgaag gcattacgct ttacttaaat gctaaaaagc 1994401 ttggcggagc agcacacgca cagccaatca aactcgatta ttgcagcaat tgcaatgacg 1994461 agttgaacac ccctgaagca tatgaaaaac taattcacga ctgtcttctt ggcgatgcaa 1994521 caaactttgc acactgggat gaagttgccc tttcttggag ctttgtcgac tctatttctg 1994581 aaacatgggc agcaaacaaa accttatctc ctaactacga atcaggctca atgggaccga 1994641 aagaatctga tgatcttttg gtgaaagacg gcttacactg gtggaacata taataagaag 1994701 aaaaaagccg aaaatgttta caagcatttt cggctttttt acgctgaaca aaggtataac 1994761 aatctcctta ataacaaaac ccccaaagct taagagcttc gggggtttct attgattact 1994821 tcatccattc agtatggaag atgccttctt tgtcagtacg ctcataagta tgagcgccaa 1994881 agtagtcgcg ctgtgcttgg attaagtttg caggcagtac ggctgtgcgg tagctgtcat 1994941 agtaggctaa tgcgcttgag aatgatggca ccggcacacc ttgggcaact gcaagtgaaa 1995001 tcacttggcg aagcgctcct tgatagcttt ctacaatatt cttgaaatag ctgtcaagaa 1995061 gcaggttgtc aagctcaggc tcgcgatcgt aagcttcttt gatcttctga aggaatgccg 1995121 cgcgaatgat gcaaccaccg cggaagatca tagcgatttc accatatttc agatcccagt 1995181 tgtattcttc agaagcagct ttcatttggg caaatccttg cgcgtatgaa cagattttac 1995241 tcatgaacaa cgcttttctg accgcttcaa tcagctcttc tttattttct gtaacaggct 1995301 tcacttctgg tcctgaaaga agtccgctcg cttttacacg ctcttccttc atagctgaga 1995361 taaagcgtgc gaatacagat tcagtaataa tcggaagcgg aacgcctaag tcaagtgcgc 1995421 tttggcttgt ccattttcct gttccttttt ggcctgcttt atcaagaatc acatcaacaa 1995481 gcggtttgcc tgtttcttcg tctttttttg tgaagatgtc agccgtaatc tcaatcaggt 1995541 agctatcaag ctcaccttta ttccattcag cgaaaacttc atgaagctca tcagcagaaa 1995601 ggcccagcac ctgtttcaga atgaaatatg attcagagat cagctgcata tctccgtatt 1995661 caattccgtt gtgcaccatt tttacgtaat ggccggcgcc gtccggaccg atatatgtcg 1995721 tacaaggttc tccgtcaact tttgcagaaa tggcttcaag aatcggtttt acaagctcat 1995781 gtgcttcttt ttgtccgcca ggcatgatag aaggtccttt aagcgctcct tcttctccgc 1995841 cggaaacgcc tgttccgata aaatgaatgc cgctttcagc gagttctttg ttacggcgct 1995901 gtgtatcttt atagtatgta ttaccgccgt caattaaaat atcatccttc tctagatgag 1995961 gaagaagaga ttgaattgtc gcatctgttg cagttcccgc tttaaccatt aataagattt 1996021 tgcgcggtgt ttccaaggat tggacaaatt cttcaatgct gtaagtgcca acaacatttt 1996081 ttccttttgc ctcctgtaaa aactcctcag ttttactgct tgatctgttg taaacagaaa 1996141 cagaaaatcc ccggctttcg atatttaaag ccagattttt acccatgacc gcaagtccga 1996201 taacgccgat ttgttgtttt gacatattct aacgtccctt ctgcaaacgt ttaatcattt 1996261 taaaatttaa attaaaataa aatgatattt ataataaaga aattaccata cattcaccct 1996321 ttttttcaag cgattcagct tttcttttca tcttgaaaaa aatctttatt aaagcttgtt 1996381 ccctttgttt tgctctcctc tttttttaac gttgcccctt ttctgatcag tttggtaccg 1996441 tactttttat tcagcttttc catcatctgc tgaatgggct catccttcgc atcttcatta 1996501 aagctgaaca aatcgagctg tttataggcc tgctcttttt ctactaaatc cgttccggta 1996561 atgccaagca gcctgacagg atttttattc caatgtttaa aaaagaggtg ctccgcttct 1996621 ttcaaaatgt catttttttg atcaatcggg tttctcagcg tagtgcttct tgtgatggtt 1996681 ctccaatccg catatctaat cataataaaa agcttcgaag ccatgacttc cttgcgctgt 1996741 aaacggtcac tcacagaagc ggcaagcttt ctaaaaacgc ctaacagctc ttcttcatca 1996801 ctggaatcat gggaaagtgt cgatgagttg ccgacgcttt taaattcgta aatgcgctcc 1996861 gggtcaaccg gcgcatggtg aatgccattt gctttatttt taaggcgcgg accgttgatg 1996921 ccaagcaggc gcttcagcga gtgttcatca gctgcagcta gctctccgat tgtatggatg 1996981 ccgagtccct tcagtttttc cgctgtcttt ttgccgactc cgtgcatctc tccaacagga 1997041 agcggccaca ggatatcggg cacttgcctc tttcttaaga tcgtaattcc aagcggtttt 1997101 ttcatatcag acgccatctt agcgagaaat ttattcggtg caatccctat gcttgacggg 1997161 agcagcagct ctttttgcag cctgctttgg atttcttttg ccgtctctag agcgcggctg 1997221 ctgtatggtg tatcggtcat gtccatatag ccttcgtcga tggagacagg ctccactagg 1997281 tcagtatatt cacgaagaat ggtaaacatc gctcgtgaag agtttctata gcggtcaaag 1997341 ttcggcggaa gaacgatgag ctcaggacaa tggcgcttcg cttgccaaac cggcatcgtt 1997401 gttttgacgc cgcgcgctct tgcttcgtag ctgcatgtta ccacaatgcc ctttcgctcc 1997461 tttacgtttc cggcaactgc gaccggcttt ccccggagag ccggatcata tgccatttca 1997521 accgacgcat aaaagctatt catatcaata tggaaaataa ttcggctctt tcccggcata 1997581 aacaaatctc cttttcggtc attagacaac agcttgtaca tatagtaaaa tgaagctatt 1997641 gaatggatgt gatgacaatg tttgtggaat cgataaatga cgttttattc ttagtcgatt 1997701 ttttcacaat tattcttcct gctctaacgg caatcgggat tgcattcctc ttacgggagt 1997761 gccgtgcggg cgagcaatgg aaatcaaaac gaacagatga acatcagacg gtctttcaca 1997821 ttaaccgaac agactttctt attattatat atcatcgcat tacaacttgg atacgtaaag 1997881 tcttccgcat gaattcgcct gtgaacgatg aggaagacgc cggttctctt cttttataaa 1997941 ccgcatttat aaaaaggagg agaacaaaat tgttaaaaac atatcaaaaa cttttggcta 1998001 tgggtatctt tttgatcgta ttatgctcgg gcaatgctgc atttgcagcg actaatcagg 1998061 tgggaggcct cagcaacgta ggttttttcc acgattattt aatcgaaccg ttttccgctc 1998121 tgcttaaggg tgttgccggg ctgtttcacg gagaatacgg actctctatt atcctcgtaa 1998181 ccattattgt gcgtatagtt gtattgcctt tgtttgtcaa tcagttcaaa aaacagcgca 1998241 tcttccaaga gaaaatggcc gttattaaac ctcaggttga cagtatccag gttaagttga 1998301 aaaagacgaa ggacccggaa aagcaaaaag agctgcaaat ggaaatgatg aagctgtatc 1998361 aggagcataa tatcaacccg cttgcgatgg gctgtcttcc aatgctgatt cagtctccga 1998421 ttatgattgg gctttattac gcgattcgct caacacctga aattgcgtca cactcgtttc 1998481 tatggttcag tttagggcaa tctgatattc tcatgtccct tagtgcaggg attatgtatt 1998541 ttgtccaagc ctatatcgct caaaaactga gcgcgaaata ttccgctgtc ccgcaaaacc 1998601 ctgcagcgca gcaatccgca aaattgatgg tgttcatctt ccctgtgatg atgacgattt 1998661 tctcgcttaa tgtgccggca gcccttccgc tgtactggtt tacaagcgga ctgtttttga 1998721 cagtgcaaaa catcgtcctt cagatgacgc atcataaaag taaaaaaaca gccgctctta 1998781 ctgagtcggt gaaataaaaa agcaaccccg tgcaaaaagc cggggttgtt ttttgttact 1998841 tgcaaagtac cgcgccaaac agtcttgttt atcatggctg aagcagaaat ggccatccta 1998901 aaaaatagcc gtatcgttta aaaagaagga aatcgggaat acctttactc acctccaacc 1998961 gaaaggagcc tatacgttga cggaacgctt tcagcaaaaa aatatttctg tacctgatgg 1999021 aatctggatc atgagacaaa cctggaatga tgtcttattt gctcactggc ctgttgatgt 1999081 ttctatcctt cgcgctttgg taccgtccgt tttagaatta gatacatata acgggcaagc 1999141 ttggatcagc atgcttccct ttatgctcac gaacctgagg gcgcgttatc tccctgtcat 1999201 tcccggtgcg cgtgcatttc ctgagcttaa cctccgcacc tatgtcacgt ataaaggcaa 1999261 gcccggcatt tattttttta gcttagatgc cgatcatcgt ctggcggtcc ttggcgctcg 1999321 cacattcttt catctgcctt atttttacgc ggatatgaag tccgaaaaaa acggtgatgc 1999381 cattgactat gtcagcaagc ggaaaaatga caaagaagca gcattccacg ccgcataccg 1999441 gccaatttca gcgcctttta cagcagaaaa ggattcgctc gattactggc tgacagaacg 1999501 atacaggctc tacaccactt atcgcaataa gctctattac gaagacatcc atcatcatcc 1999561 gtggctgctg caaaacgccg aagcagaaat ttcagtcaat acggtgactg atgctcacgg 1999621 tattacattg ccggagtcag accccttgct tcattatgct aaaaaacagg atgtgttatt 1999681 ttggccgctt aggaaatgga gctaaaaaaa cccgatgcgg gaaatcgcac tcgggttttc 1999741 tttttttatt ttgccgcctc ttcaataatg gcaacaacca tttctgccgt tttaacgagc 1999801 tcttcgatcg gcattttttc attttttgta tggatttgct cataaccgac agcaagattg 1999861 accgtcggga tgccatgacc agcgattacg ttcgcgtcgc ttccgccgcc gctcgtttgc 1999921 agctcgcttg gacgtccgat tttagcagcc gcttttttcg cgatttcaac aacttggtcg 1999981 ccgtcttgat atttaaagcc cggatacata acctcaattt cgacttctgc gcgtccgccc 2000041 atatcagcag ctgcctcttc aaaagcagct ttcatttttt gaacctgagc ttccattttc 2000101 tcaggaacta aagagcgcgc ttcagcaaga atatgaactt cgtcgcacac aatgtttgtt 2000161 tgtgtgccgc cttcaaaccg gccgatatta gctgttgttt cttcatcgat acggcccaat 2000221 ggcatttttg agatggcttt gctagcgatt gtaatcgctg aaatgccttt ttcaggttca 2000281 accccggcgt gagcggtttt cccgaaaatt gccgctctta ccttcgcctg tgtcggcgcg 2000341 gccacaatga tatttccgac ttttccgtct gaatcaagag catagccgta ggatgcagtg 2000401 atcatagaac ggtcaagcgc cttcgctccg atcagacccg attcttcccc tactgtgatg 2000461 atgaattcaa tcgtgccgtg ttcaatattt tcttctttca gcaccttaat cgcctcaaac 2000521 attgcagcca atcccgcttt atcatcagca cctaaaatcg tcgtgccgtc agttttgacg 2000581 taaccgttct ctacaactgg ttttacgccg tttccgggta caactgtgtc catatgagat 2000641 gtaaaataga tcgtatctgt ttgttttgtc ccttttagcg tgcaaatcag gttaccggct 2000701 ccgtggcccg tgatatccat tgtatcgtct tctttaacgt ccacacctaa atcagaaaat 2000761 tttcgtttca gcactttgca gatttcagct tcgtgctttg tttctgagtc aatttggaca 2000821 agctctaaaa attcttccag caggcgtttt tcattcacca tttgtaagtc cctccatatt 2000881 aaagcggtat gttaccgtgc ttttttttcg gtctctcttc tgtcttatgt gtaagcatat 2000941 gaaaagcttg aatcagtctt ccccttgatt cttccggcaa aatgatgtca tcgaccattc 2001001 cacaagcggc cgctttgtat gggccggcgt tttgcttttt gtattcagca gttttttcgc 2001061 gtttcgtctt ttgcgggtca gctgaagctt tgatttcctt ttcatacaaa atcgatgccg 2001121 caccttctgg acccatcact gcgatttcag cattcggcca tgcaaacaca aggtccgctc 2001181 cgatcgcttt gctgttcatg gccacatagg cgccgccgta cgcttttcta atgatgagtg 2001241 tgacttttgg gacagtcgct tcagcataag caaacaataa ttttgctcca tgcctgatga 2001301 ttccgttgtg ctcttgctga atacccggca gaaaccccgg gacatcttcg acagtcaaca 2001361 gcgggatatc aaatgcgtca caaaaacgga tgaaccttgc tgctttatca gcagcgtcaa 2001421 tcgtcaggct tcccgccaga tgcttcggct ggctcgccac gatgccgatt gctttttcac 2001481 ccagccttgc aaacccaatg acaatgttct tcgcaaaaaa tggctgaatc tcaaaaaaag 2001541 actgcgggtc agccagctcc ctaatcacct tccgaacatc ataaggcttt gtcgtatcag 2001601 cagggacaag acggtttaat aacggtctgg acgcctcttt ctctggcttc ggctctgttg 2001661 tccggccatt cagcggcaaa taagacagta gttttctcac ccctgtcaga acctccttct 2001721 ccgtatgccc ggaaaagtgg gcgtttccgc tgacggcatt atgtatcccc gctccgccta 2001781 agctctccgc atcaacctgt tcccctgtca ctttttcaat caccttcggg ccggtaataa 2001841 acatccggcc agtctgttca gccataaata taaaatctgt gagtgccgga gaatatacag 2001901 cgcctccagc gcacggccct aaaataaccg atatttgcgg aatgactccg gaatataaga 2001961 cgtttcggta aaatatgtga ccgtatccat ctaatgataa cacaccctct tgaattctcg 2002021 caccacctga gtcattcagc ccgataatcg gcgccttatt ttttgctgcc agatccatca 2002081 aagcgcagat tttcctggca tgggtttcgc caagcgcccc tccgtacact gtgaagtctt 2002141 gcgcaaatac ataaactgag cgaccgtcaa ttgtgccgta ccctgtcacg accccatccc 2002201 ctaacatgcg ctgttctctt gttaacactt gactttccat gaaggggtgt aattcgataa 2002261 agctgtcctg atctagaaga aatatgatcc tttcccgagc agtgagcttg cccttttgcc 2002321 gctgctgagc cagcttttcc cgtcctccgc cttcttctgc ctgcttgcgt ttcgtgtaaa 2002381 aatgatccat gtgctcattc atgctcattg tgttggtctc ctttcggttc acaaagctct 2002441 acaagaacac cgtttgtttc ccgaggggaa ataaacgcga tctttttccc gttcgctccc 2002501 tgtcttggaa acctgtcaat caattgaaca tgctgatcag acaatgcttg aagctgttca 2002561 gataggcagt tgcacaaaaa cgcaatatga tgcagtccct gccctttctt ctccaaaaat 2002621 aaatggacgg ggctgtcagc tgtcaacggc tctatcagct caagtttgac gctaccagct 2002681 tgaaaaaaag caacattcac cttttgctct tcaaccgttt cttgatgaag aaatgcaagc 2002741 cccaatacat tttcataaaa gcttcttgca tcttttatcg aaaaaacggc tatcccgata 2002801 tggtcaagcc tgttcatttt catccctgct ttcgctaata gatatcgctt gtccgcccat 2002861 tcaaaacacg ctaaaatata gacagattgt ttaaggagtg aaaatcatgt ctcaaaaact 2002921 gatgaaaagc gttttgatcg tgattttggg agtttttatt ctttcaactg tactctcagg 2002981 aatcgtcatg tttctataac gataaaaaag caggcgcctt attcaatggg aatatcctgc 2003041 ttttttatca gagctttatg ctcgatggca atctcctcaa aagagcggtt gtcgtccgtg 2003101 atcagcactc tcgttcctac tggtatcgtt tgaaacaaat gaacaacctc atcgttatgc 2003161 atacgtatac agccgttaga cacaaatttt cctactgatt cctctcggtt tgtcccatga 2003221 attccataaa tccgcccgtc cgttcctttc gcgtcaaatc cgatccatct tgccccaagc 2003281 gggttatcag gagatccccc ttcaatattt ttctttctgt agtaaggatt ttccgctttt 2003341 accgttaccg aaaactctcc ttcaggcgtc aaatcatctg tttttccagt cgccacacta 2003401 tacacgcctt ctactttgtt gtcgaggata acagcaagtt catttgttcg cttgttgaca 2003461 ataacatacg gatcacccgg cagcggattt tcgccgagcg gccaaatcgg tgaaatcatc 2003521 atgaaaatcg aacataagaa aaaacgcata agctcctcct ttttcattag gttgaccaat 2003581 gaaggaagag ctcatgcgaa tcatccgagt gatttttgcg cttttattcc tttaaaataa 2003641 cttttaatca ctaaatattg ttccatttcg ccgagaagat ggaagagagc ggccctcgct 2003701 tcaaattcct ctctagtcgc aggaagcggc atctcctcaa attcttttct catgtcagca 2003761 agtcttttca gaaatttgta tgctgtattc ccagggtgta tcgcctcccg caaatcatga 2003821 ataaattcag cgatcatttt tccctgatct accgtgatgg agatcgatgt cactttaggg 2003881 agaaggcgtt cgataatttc aaattgcttt tctctcattt taaaataatg ataatgcaga 2003941 ttttcataac gcaaaatgtg gttttgcaca tctcgatatg ccaggttttt agcctccgta 2004001 atgagctggt gcgtttccgg aatttctttt cctgaccaat cttgctcacc agttaacaaa 2004061 taccgttcga tttctgcaaa aatgacagca aagttatcct ctatcttttt gcggtaggca 2004121 atcagtttcc ggtcaagact aggcatatac aagttcatca atagagcgac gccgatgcca 2004181 accgtaatca gctgaacttc attccagatg aaagtaggcg taatgccgcc ggacatgtat 2004241 aaatgaagga taataacaga actggtgacg ataccctcgt taatttttaa cagaaccgtt 2004301 atcggaatga atatcaaaag aagcgctccg atcacaaacg ggtggtagcc aataagctcg 2004361 aaaaagagat aagaaaaagc aattgccaga cagcatgccg aaaagcgggc ccatgaggcc 2004421 tgaagcgacc gtttttgtgt gatttgtatg cacaaaatgg tgatgattcc tgctgatgcg 2004481 aagttttgca aatgcaataa ctggcttata taaatagcca aagctgttcc aagcgcggtc 2004541 tttattgtgc ggtaaccaat tttaaacatg tcggactcca tttctatttg tttcttcaat 2004601 aaaaaagaag aggcggccag ccttcttctt ttttatattc tataatattt tctctaaaaa 2004661 gtcctgcgct cttttggatt ttggcgacat aaaaaattcc ttcggattgc cgtcttcgac 2004721 aatcattcct tggtccataa acagcacacg gtctgccact tcttttgcga agcccatttc 2004781 atgtgtgaca atcaccatgg tcatgccggt ttcgaccagc tctttcatca cctgtagcac 2004841 ttctttgacc atctctggat caagggcgga ggtcggctcg tcaaacagca tgatgtccgg 2004901 attcatcgca agagccctgg caatcgcgac acgctgtttt tgtccgccag acaaacggtt 2004961 tggatagtca tttcgctttt caaacaaacc gactttgcgg agcaggtcct cagctttctc 2005021 ctgtgcagcc tgttttgatt ctttttttac attgacaggc gcgtacatga tgttttcgag 2005081 aaccgttttg tgcggaaaga gatgaaaatg ctgaaaaacc atcccgatgt tttcccggac 2005141 ctttaatgtg ttggttttcg gcttcgtaat ctctgtgtct tttattgtaa tggttccgcc 2005201 gttaggcttt tccaacaggt ttaaacagcg taagaacgtt gatttgcctg agcctgaagg 2005261 accgatcacg gcaacaacct caccctcagc gattgttgtt gaaatgtttt ttaatacttc 2005321 gtgtttccca aatgattttg acagcttttc aaccttaatc attggatttc agcttccttt 2005381 ctacagcctt gccgataaac gttaaaatca ggacaagcac ataataaatc aatcccgcga 2005441 taatgagcgg ctcaaggtaa ttgtaagtgg cggcgccagc ttgatatgcg cgtctcatga 2005501 catcaccaag cccgatgacg gtgacgatcg ccgattcttt tgttaacgta attaattcat 2005561 tcacaattgc aggtgatata tttttgaagg cctgcggcag cagcagatcc ttcatcattt 2005621 ttccatacgg gacaccgagt gcaacagcag cttctttttg ccctttatca atggcattga 2005681 ttccggctct gataatttcc gatacataag cggcggaatt caaagacaat gcgacaaccg 2005741 cagcccaaaa ctggtcaatt tgaaatccga gcagctgagg aaggccaaaa tagacaatca 2005801 taagctgcag cactaaaggc gtgcctcgga acactgatgt ataaaaatca gcgatccaga 2005861 taaacgggcg gaatgtgctg atcttgcata agcttagcac aataccgagt ataagtccga 2005921 taatagcaga tacaacaaca atttttaatg taattgccaa gccttctaat ataaaaggaa 2005981 tttgggggat cgttgctgaa aaatccaaat tcatagcctt tgtctccttt tcttacagga 2006041 aaaaagtttc ctattcaata aaaaggctca acgaaaaagt tgagccgctt ttttttactt 2006101 ctcgccagtg aaccattttt tcttcaattt ctcaagctct ccgttatctt ccatttcctt 2006161 gagcgcttta ttgaatttgt ctgtcagttc actgtccttt ctgaaagcaa ttgctgaacc 2006221 ggcttcttcc gctttcgcat caggaatcac aaagccttgc aggtcatcat ttgatttgaa 2006281 atacccttct gcaacaatgt cttcaataat cgcggcatcg aagcggtcag atttgatttc 2006341 ctgcaccaaa tcagaaattc tgttgcggtc ttctgtttta aaaccatatt ccggagaaag 2006401 ctctttcccc ttctcttcct gaatagagcc aagctgaacg ccaactgttt ttcctttcag 2006461 gtctttcaaa gattgaatgc cgctgtcttt tttgctgaca atcatatggt tcgctgtgta 2006521 atacacatcg gaaaaatcaa cttgtttttt acgctcaggc gttggtgtca ttcctgacag 2006581 aacgagatcc acctgttttg atttaagcgc tgtaattaag ctgttgaagt ccatatcctg 2006641 cacttcaatt tcatagcctg ccttctttgc cagagctttt gccagctcta catcaaagcc 2006701 gacaatatta tctccttctt tatattcaaa cggtttgtaa tccgccgaag tacccataat 2006761 taattttttc tttccgcttt ctgaacctga attgcttgag ccgcacgcag ttaatgcaaa 2006821 ggtgatgcaa gcagccacaa gtaataagag ccattttttc atgatccatt tcccccgtat 2006881 tcattacttt tggtgtattt gaatatttat tcgttaattt gtattttaaa cagtttctca 2006941 tttttatgca atactatttt taaaaattat ctttaggctt atctttccag tgatctcttc 2007001 tgatattact agataaaaat taaatcgctg tacaatccga ttgaataatc ccttaatatt 2007061 tattcatata tccttggaaa tttatgcaca aaaaaacccg ggctgctttg agcatccggg 2007121 ttgttcgtct tatacttctt cacaatattc ttcaaaggct tcctgcagct ttgccactac 2007181 agccatcggc tcatggcctt caatttcatg acgctctacc attttcatga tctttccgtc 2007241 tttcaaaatc gcaaaggacg gagaagatgg tggataacct tcaaaatagt cacgcgcacg 2007301 cgctgtcgct tctttatcct gtccggcaaa aacggtgacg agctgatcag gtcttttatc 2007361 atagtgaacg gaatggtagg ctgccggtct tgcaattcct ccggcgcatc cgcaaacaga 2007421 gtttaccatg acgagcgtcg ttcctttttt cgtaagtgcc tcatccacct cttcggctgt 2007481 tttaagctcg gtgtatccgg cagctgttat ttcttgtctc gcttggcgga caatatcatt 2007541 cataaataaa ttaaagtcca tgttcaatga agacctctcc tttttcatca tctgttctta 2007601 tgatagcaag gaaacgtcca tatcggcaaa tgactttgct tcgccgtgca ctttttttgc 2007661 tcttcgttta ctgcttacag aaaaagggga ttatataacc agaagtaaaa taaaggagca 2007721 gttgtatatg agccaccgga aagcgttact gattcataac ggaaatgccg gcaacaaaaa 2007781 tatagaaaaa gcacttggtg ctgtggtgcc ggttttatct caccatttag atgaggtgat 2007841 tattaaacag acaaagaaaa aggatgatgc gtatcatttt tgccgatcca ttgatgattc 2007901 tgtcgacacc gtcttcattc tcggcggcga cggcacgatc catcaatgca taaatgctat 2007961 cagcgctcta gaaagaaaac ccgctgtcgg aattttgccc ggcggcacgt gcaacgactt 2008021 ttcaagagtg cttggcatcc ctcaaaatct tgcaaaggcc gcggaagcac ttatggcggg 2008081 aaaaaaaacc agcgtagacg tatgtcagat gaatgaccgt tattttttga atttctgggg 2008141 gatcggctta attgcagaaa cgtcgaatca aatcaacgaa acggaaaaag cattattggg 2008201 aaaaatcagc tattttacaa gtgccttgcg aaccgtctca tctgctgcat cgtttccgat 2008261 gacattaaaa attgatggag aagaaattaa agaagaagcc gttatgctgc ttgtgatgaa 2008321 tggccaatac attggaacga atcgaattcc tctgcccgat gccagtattg aagacggctt 2008381 acttgatgtt ctcatatgcc gcaataccaa cctcaccgcg ctgcgggagc tgatgagcat 2008441 ggaacaaggc tcaattgatc gttttactgg agagttgtcc tatgtccagg cttcccgtat 2008501 cgagattgaa acagacactg ccaaaaaggc ggatatggat ggagaagttt atacacatac 2008561 acccgcagtc attcaggtcc tgccacagca tatcgacatg cttgttcccg caaatgaata 2008621 actgtcataa ggctttagaa agattttgca aatccgttga ctctccccta ggaggaggtc 2008681 ttacagtata agggatacac acttgaaaaa ggggaagtca tatggagaag aaaaatatta 2008741 ccttaactat attattaacc aatttattta ttgctttttt ggggatcggg cttgtgattc 2008801 cagtaacgcc gaccattatg aatgaattgc atttatcggg gaccgcggtc ggctatatgg 2008861 ttgcctgctt cgctattaca cagctcattg tctcaccaat agccggacga tgggttgatc 2008921 gcttcgggcg caagatcatg atcgtaatcg gcctgttgtt ctttagtgtg tcggagtttt 2008981 tgttcggcat tggaaaaaca gttgagatgt tatttatctc ccgtatgctg ggcggtatca 2009041 gcgcagcctt cattatgccc ggggtcacgg cttttattgc agatatcacg accattaaaa 2009101 cacggccaaa agcgctcggt tatatgtcag ccgctatttc aacaggattt attatcggcc 2009161 ccggcatcgg gggattttta gcagaagtcc attcccggct gccttttttc tttgcggcag 2009221 cttttgcact gttagcagcc attttatcaa tcctcacgct gcgcgagccg gaacgaaacc 2009281 ctgaaaatca ggaaataaaa ggacagaaga caggctttaa acgaattttt gcccccatgt 2009341 atttcatagc ttttctcatt atcttaattt cgtcttttgg tttagcatca tttgaatctt 2009401 tatttgcatt attcgtggat cataaattcg gatttacggc cagcgacatt gccattatga 2009461 ttacaggagg agcgattgtt ggcgccatta cgcaagtcgt cttattcgac cgcttcacaa 2009521 gatggtttgg cgaaattcat ttaattcggt acagcttaat tctctcgacg agtctggtat 2009581 tcttgctgac aacggtacat tcatatgttg cgattctgct ggtgacagtc accgtatttg 2009641 tcggatttga tctcatgcgg cctgcggtaa cgacttacct gtcaaagatt gcgggaaatg 2009701 aacaggggtt tgccggcggt atgaattcaa tgtttacaag tatcggcaat gtattcgggc 2009761 ctattatcgg cggaatgctg ttcgatatag atgtaaacta tcctttctac tttgcaacgg 2009821 tcaccttagc catagggatt gcactgacca ttgcttggaa agcgcctgca catcttaaag 2009881 ccagcacgtg ataagaagcg cattctttgt gtactgcaaa gaatgcgctt cttctttata 2009941 ctgatgatag aaggagtgat ggcatgaagg aatcgtatta ctcaattggg gaagtatcaa 2010001 aactggcaaa cgtgtcgata aaagcgctcc gttattacga taaaattgat ttatttaaac 2010061 cagcctacgt cgacccggat accagctacc gctattatac agattctcag ctcattcatc 2010121 tggatttgat caaatcattg aaatatatcg gcacaccttt agaagagatg aaaaaagcac 2010181 aggacttaga gatggaagaa ctgtttgctt tttatacaga gcaggagagg caaatcaggg 2010241 agaaattaga ctttttatca gccctggagc aaaccatttc attggtgaaa aagcggatga 2010301 aacggcagat ggaatatccc gcgctcggtg aggtgtttgt tttagatgaa gaagaaatac 2010361 ggatcattca gacagaggca gaaggaatcg ggcctgaaaa cgtgctcaac gcctcctaca 2010421 gcaaattaaa aaaatttatc gagtcagcag atggatttac gaacaatagc tacggcgcta 2010481 ctttctcttt tcagccctac accagcattg atgaaatgac ttaccgtcat attttcacac 2010541 ctgtattgac gaataaacag atttcatcaa ttacgccgga tatggaaatc acaacgatcc 2010601 ctaaagggag gtatgcgtgt atcgcgtata atttttcgcc tgaacattat tttctcaact 2010661 tacagaagct tatcaaatat atcgcggacc gccaattaac agttgtcagt gatgtatacg 2010721 agttaatcat accgattcat tactccccga aaaaacaaga agaatatcga gtcgaaatga 2010781 aaatacggat cgctgaataa taaagcatag aaaaagagca ttttttgaaa caaaacttca 2010841 aaaaatgctc tttttgctta tttagtaaac agatgtcttc tcgtcaatcg attctaaaat 2010901 ttgtttcact cgtccgagga atcgtccgca cacgagaccg tcaagcactc tgtgatctaa 2010961 tgacaggcac agattaacca tgtctctgac agcaatcatg ccattgtcca tgacaaccgg 2011021 gcgtttgacg atggattcta cttgaagaat cgcagcctga gggtagttga taatgcccat 2011081 cgactgaaca gacccgaacg aacctgtgtt gttgacggta aacgtgcctc cctgcatgtc 2011141 atctgcagtg agttttccgt ctcttacttt tttagctagg ccggtaatgt ctttcgcaat 2011201 gcctttaatt gttttttcat cagcgttttt aatcaccgga acaaataaag aatcctctgt 2011261 ggcaactgca attgaaatat tgatatcctt tttctgaata attttgtccc ccgcccacat 2011321 gctattcatt tgcgggaatt cttttaacgc ctgagcgacc gcttttacaa aaaaggcgaa 2011381 gaacgttaaa ttaaagcctt ctgtcttctt aaaagaatct tttatactgt tgcgatatgc 2011441 aaccatattt gtgacgtcga cttccatcat cgtccaagca tgcggaattt ctgttttgct 2011501 tcgcttcata ttggaagcaa ttgcttttct tacacctgtg acagggattt ctttatcacc 2011561 ggctgcagac gcaggatatg acgtctcttc ttttggctca ggttttgatg cagacttcgg 2011621 tgcaggagct gctgttttca gctcctcagg attctgttct tgcacgccgc ctgtttcaat 2011681 taagcgctga atatcttttc gtgtgatgcg cccgccggca ccagttcctg tcacttgatc 2011741 gaggtcaatg ccgtgctctc cggccaaacg gagaacagct ggcgagtagc gctttttatt 2011801 gggctgatcg gctgctccag cactttttgc aacagggttc tcagcggctt ctgatgctgc 2011861 tggctgttct tgtttttgtt cagccggatt cgcgccttct gtttcaattt tgcaaatcat 2011921 ttctccgact tgcagggttt ggccttcttc tcccacaagc tctgttatcg taccagtaaa 2011981 agaagacgga acctctgcat ttaccttatc tgtcatgact tccgcgatcg gatcgtattt 2012041 gttcacttta tcaccggggg cgacaagcca tttgctgatc gtcccctctg ttacgctttc 2012101 tccaagctgc ggcatcgtca tttgttcaat tgccatgatt gtatcctccc ttacgtcttt 2012161 aaaactccgc taattctctc atcgccgctt ccactttatc agggttgacc ataaagtatt 2012221 tttccattgt cggcgcataa ggcatagccg gaatatcagg acctgcaagc cgtttgatcg 2012281 gcgcgtctaa gtcgaacaga caatgctcgg atataattgc ggctacttcg ctcatgatgc 2012341 tgccttcttt tgtatcttct gtgaccaaaa gaacctttcc agttttggac gcagcttcga 2012401 tgatggcttc tttatcaagc gggtaaactg ttcttaaatc caccacatgc gctgaaatgc 2012461 catctttttc gagacgttct gcagcttgta aggcgaagtg gacacacagg ccgtatgtga 2012521 tcactgtgat gtcgtcgcct tcccttttta cgtccgcctt gccgattggc aggacataat 2012581 catcagccgg aacctcgccc tttatcagac ggtatgcccg cttgtgctca aaaaacagca 2012641 cggggtcttc gtcacgaact gcggctttta agagcccttt cgcgtcatat ggtgttgatg 2012701 gcatgacaat tttcagtccg ggctggttgg cgaaaattgc ttcgactgat tgagaatgat 2012761 acagggctcc gtgcacgcct ccgccgtatg gcgctctgac gacaatcgga cagctccagt 2012821 cattgttgct gcggtagcgg attttagccg cttcagaaat aatttggttg actgccggca 2012881 taatgaaatc agcaaactgc atttcagcaa tcggtctcat tccgtacatt gccgctccga 2012941 taccgactcc tgcgattgca gattcagcaa gcggcgtatc cataacgcgc tcttccccaa 2013001 attgttcata gagtcccgct gtcgctttaa acacaccgcc ttttcttcct acatcttccc 2013061 caaggacgaa aacgcgagaa tctcgttcca tttcttcttt catcgccaaa ttgattgcat 2013121 caatatatga cattactgac atttgttctt cctccctact tcgcataaac ataatcaagc 2013181 gctgactcag gagctgcata tggggcgttc tccgcttcat ccgtcgcttc atttacgatt 2013241 gccataattt catccagcat ggtttgttct atctcatcgg acagcaggcc tgtttccttt 2013301 aagtaagctt gataagtaag caggggatca ctttttttcg cttcctctac ttcttcacgg 2013361 cctctgtagc tgctgtcatc gtcatcactg gaatgtggtg taaggcggta agaaatcgtt 2013421 tcaattaatg tcgggccttc tcctctgcgt gccctttcgc gtgcttcttt aaccgcttga 2013481 taaacttcca gcggatcatt tccattcaca gttacgccag gcatcccata gcctatggca 2013541 cggtcggaaa tgttctcaca tgcgacttgc ttatcgtaag gcactgagat tgcgtatttg 2013601 ttgttttcac acatgaaaat aaccggcagc ttatggacag cggcaaagtt tgccccttca 2013661 tggaaatcgc cttggtttga agacccttcc ccgaatgtaa caaaggctgc gatatccttt 2013721 ttctccatac gtcccgcaag cgcaataccg actgcgtgcg gcacttgcgt tgtaaccgga 2013781 gatgatcccg tcacaatgcg gtttttcttt tgtccgaaat gtcccggcat ctggcggcct 2013841 cctgagttcg gatctgctgc ttttgcaaac ccggacatca ttaagtcctt tgctgtcatg 2013901 ccaaacgcga gcacgacacc catgtctctg tagtacggca atacataatc catttcacgg 2013961 tcaagtgcga aagccgctcc tacctgtgct gcttcctgtc cttgacaaga gattacaaat 2014021 ggaattttgc cagaacggtt taacagccac attctttcat cgatttttct tgctaacagc 2014081 atggttctat acatatcaac ggcttcctga tcagtcagcc ctagtgcttg atgtcggttt 2014141 gtactcattc aagcccctcc tttatgcttt taaaaatgaa tggctttgcc atctgcggca 2014201 agcgcagctt ctccaattgc ttcagaaagc gttggatgcg ggtgaatcgt ttgcccgacc 2014261 tcccacggtg ttgcgtccag cactttggca agacccgctt cagaaatcat gtcggtgaca 2014321 tgcgggccaa tcatatgaac gccgagaata tcatctgtat ctcggtcagc cacgattttg 2014381 acaaaaccgt cgctttcacc gtatacaagc gcttttccaa tcgccataaa tgggaacttg 2014441 ccgattttga cattatgccc gttcgccttt gcttcgtctt cggttaagcc gacactggca 2014501 gcttcagggc ttgagtaaat gcacttcggc acaagcgtcg gatcaagcgg atgcggattg 2014561 agacctgcaa aatgctcaac agcaataatt ccctcatgtg aagcaacgtg agctaactgc 2014621 aggccaccga ttacgtctcc gattgcataa atatgagatt ccttcgtttg gcagctttca 2014681 ttgactgaaa tcatgccatt ttcagtaaca atatcggtgt tctctaggcc gatgccttcg 2014741 atatttgcct gtctgccgat ggaaacaagc attttctcag cagaataggt aacggtttct 2014801 ccgtcttttt ccgcttgtat gctgatatcg tctgatgttt ttgtcattgt gtcaggcagc 2014861 acttttgccc ctgttatgaa ctggatgcct tttttcttaa gaagactttc catttctttt 2014921 gaaatctcta gatcttcagt cggcaatatg cgatccgcgt attcaataac cgttacctta 2014981 acgccaaaat catgaagcat agacgcccat tcgataccga taacccctcc gccgacaatg 2015041 atgattgact gtggcagctc ctccatttgg agcgcctcat ctgaagtcag tacagactta 2015101 ccgtccactt caagacccgg aagcattctc ggtcttgatc ctgttgcaat gatcacttgt 2015161 ttcgggatca gcatgtcatt ttcttcgcca tttccccgct caacagaaat tgttcccggc 2015221 agcggagaga agattgacgg tccaaggata cgtccatatc cggtgtacac gtcaattttt 2015281 ccttttttca ttaaatgatt tacacccgct gcaagcttat caacaacggc ttgcttacgc 2015341 tgctgcactt tttcaaagtt gagggacacg ccagccgttt ccactccgaa ttgatcggct 2015401 tcacgagctg tccggtatac ctctgcgctt ctaagcagcg ctttactcgg gatacagcct 2015461 ttatgcagac atgttccccc gagtttttcc ttttccacaa cggctgtttt taagccgagc 2015521 tgagcggctc tgatggccgc aacataaccg ccggtaccgc cgcccagaat gactacgtca 2015581 tactcagttg ccatggtgac tcactcctgt ctgtctattc aatacgatat tgtttggatt 2015641 gctcttcgcc ctgcaatact cttagcgccc cttgggcaag agactgcagt tcattttcac 2015701 ccggataaac taaaacgtct gaaatccaat ctatgtatga tctgatagca gaaacaaagc 2015761 tttttccgta cgcaaggcct cccgtcagca caatcgcttc aacttcgcct tttaacgccg 2015821 cgctggctgc cccgatttcc tttgctacct gatatgccat ggcatcataa atgaagcggg 2015881 ctttttcatc gcccccttga atcatctgtt ccacttttac tgcatcattt gtaccgagat 2015941 agcctaaaag tccgccggtg ccaacaagct ttttcatgat ttcttctttt gtatattccc 2016001 ctgaaaaaca tagatcaaca agatctcccg caggcactgt tcctgctcgt tcaggactga 2016061 atggtccctc gccgtgcagg ccgttattga catccaccac tcgcccgcgg tcatggacgc 2016121 caattgtaat acctccgccc atatgggtaa taatcatttt catgttctca tatcgtttgc 2016181 caagggaggc tgccgcttta cgagcgacag ctttttggtt taacgcatgg aaaatgcttt 2016241 tcctttcaat ttcaggcatg cctgaaactt tcgcaagcac tgacatttcg tctacgacaa 2016301 cagggtcgac gatatacgaa gggatattca ggccgtcagc gatttcccgc gcgataatgc 2016361 cgccgagatt agaagcatgc tgaccggcgt agccgctttt caaatcctca atcatctcat 2016421 cattcactac gtaggtcccg ccttcaattg gccggagaag gccgcctctt gcgcagactg 2016481 catcaaactt tgaaatattg attccctgtt catgaagcgt ttcgagaata tggtttttac 2016541 gaaattcata ctgatcaata attcggtcaa atcgctgcag ctcttctatg ttgtgtctca 2016601 atgttttttc aaaaatgctt ctttcgttat gaaaaacacc gattttcgtt gaagttgagc 2016661 ctggattaat tgtgagaatg cgtttttcgt catgtagcac tttcataacc tccagatcaa 2016721 tttcttaacg tctgcttaat acactgtggc cgttttgcaa aaactggctt cttgagcggc 2016781 gcatgcgttc aatccgttcc tctgctaagc ggtcagccgc taaatatgca ggaatgccgt 2016841 cacgctgaga aatctcaagt acacgctcga tattgccgta aatgccttca acttttttca 2016901 atgcacgttc tgcattatag ccgtaaagct catctgccac gttgatgaca ccgcccgcgt 2016961 taatcacgta atccggtgca taaacgatgc ccatttcgtg aatttgatca ccatggcgtg 2017021 tctcttttaa ttggttgtta gccgcacctg cgatcacttt cgccttcagc tgtttaatgg 2017081 tgtcgtcgtt aatagtcgca ccaagggcac acggcgcata aatatcgcag tcttgtgaat 2017141 aaatgtcatc aggatctacc gcacgggcgc caaaatcttc aactgcacgc tgtacagatt 2017201 gtttgttgat atccgtaacg attaagtttg ctccttcttc atgcaggtgg cggcaaaggt 2017261 tataggctac gttcccaaca ccctgtacag caatggtttt tccttcaaga gagtcggttc 2017321 cgaaagcagc tttagctgct gccttcattc ctctgtacac cccgtacgct gtgactgggg 2017381 acggatttcc agaagagccg aaagcaggag aaatccctgt gacatagtct gtctcatcat 2017441 gaatgatatc catatcctcg accgttgtgc ccacatcttc agccgtgatg tatctgccat 2017501 tcagtccttg aatatagcgg ccaaacgcgc ggaacatttc ctcatttttg tctttgcgcg 2017561 gatcgccgat aatgactgtt tttccgccgc caaggtttaa gcctgccgcc gcgttcttat 2017621 aggtcatgcc tcttgccaat ctgagcgcat cttcaattgc cgcttcttca ttttcatatg 2017681 tccacattct cgttccgcca agcgccggac caagcgttgt atcatgaatg gcgataatcg 2017741 cttttaatcc agattgttca tcctggcaga ataccaattg ttcgtaatcg tatttctcca 2017801 tatatttaaa aagttccatg ttcgttcctc ctaatgtgtg tattcttcag atgcgcatat 2017861 tgccagcgca atggaataca gtttattttc agcagagtcc gctctgcttg ttaaagcaat 2017921 cggtgctttt gctcctgtaa tgacagccgc cacgctggcc ttggcaaaat aaatcagtga 2017981 tttatataaa atattgccgg cctcaattgt tgggacgaga aggatatctg cgttgcccgc 2018041 tacgtctccc gaaatttttt tctgggccgc ggcaatttgt gaaactgcgt tatccaaagc 2018101 aagcggtcca tcaacaatgc agcctttgat ctggcccctt ttgtacattt gagctagagc 2018161 agctgcattc acggtcgctt ccattttagg gttcaccgtt tcgaccgctg caagggcagc 2018221 tgcttttggc atattgttcc ccactgcatg ggccacatga acggcatttt gcaaaatctg 2018281 ccggagctct tccagcgaag gagcaatatt cattgccgaa tctgtcacaa acatcagccg 2018341 gtcaaaatcc ggtatatcga agacagccac gtgagaaagg acacttgctg accgaagccc 2018401 ctcctgtctg ttcaataccg ctttaagcaa aacagaagtc ggcacattgc ctttcattaa 2018461 aacgtccgct gttttatgat gcacagcacg aaccgctaat ttcgccgatt cctcaggagt 2018521 attggcatgg acgatttcca cttgatgccc ttgcatggat gatgtcagct cgttcagttt 2018581 tttgctgtcg cccgttaaca agaaacgggc ggataggtgc tcggctgcca gctttacagc 2018641 ccggatcact tcctcatcct cagcatgagc aaccgcaatg gtcttatttt tgtgtatcga 2018701 cgctttgccg attaaatctt tcagcttcat ctgttaccac ctttcttgtt tcgactccgc 2018761 cttttattat gcaagttcca tgccagctct taagggtgct gtcataccag gtataccgaa 2018821 acattcgtgc agatgtttgc gtttattctg caaattattg catgccttca tttgcaaggc 2018881 catatttatc cattttgtaa tataaattcc gaatgctgac accgagagct tttgctgttt 2018941 ttgtccggtt aaaatgatgc ttttcaagcg tttgctggat caaatgcgct tcaaattttt 2019001 ctactgcgac agacagcttt tcgccttcaa tatccggaaa atcaaaacct gttccctgat 2019061 ctgtgtcatt ttctttttgc tcaagttcga atacaggcaa gtgatctttt tcaatccatt 2019121 ccatatgcgg attcagaaaa atcatggctc gtccaaggac attttcaagc tcccggacat 2019181 tcccaggcca atggtaggca gataaggcgc gcaaggcttg ctgtgagagc ccttttacat 2019241 tcctgccgta atcccggttg atcttttgga taagtctgac gctcaatgct tcaatgtcct 2019301 ccaaccgctg ccgcaaaggc gggatggaga tcggatagcg attgatccgg taatacaggt 2019361 cttcccggaa tgttccgtcc gccatcgcct tttcaatatt tacatttgtc gccgcgatca 2019421 ctctgacgtt gacagggatc gctttcgtgc cgcccactct gacgatttcc ttttcttgaa 2019481 ggacgcgtag caatttggcc tgcatatttt gtgtcagctc accgatttca tctaagaaaa 2019541 tactgccgtt atttgcttcc tcaaataaac cctttttacc gccgcgcttc gctcctgaaa 2019601 acgcaccatc ctcatagccg aacaattctg attcgagcag gttttcagaa agggctgcac 2019661 aattcacgcg aataaattta ttgtatttcc ggtcactttc gttatggatg gcatgggcga 2019721 acagttcttt tcctgttcct gattccccgc gcagcaagat ggttgccggt gttttcgcac 2019781 cgagcttcgc ctgctcaagc gcaaccagca tttgctcgct tttgccgata atgtcgtcaa 2019841 acgtgtattt cgcttcaagc gtgcgaataa tttgtctggc gcgattaagc tccgctgtca 2019901 gcattttaat ttcggaaaca tcgtgaatca cgccgacgct gcctttcaaa atcccgtcca 2019961 caatcaccgg tgctacatta acgatcactt ctttttcatt cgggccgacc ttcattctga 2020021 caccgcggac aggacgtctt gtttcaagca cctttaaatg catgctttcg ccttcggaaa 2020081 tatcagtgtt tgcaggcttg ccgatgactt ctttttcaga aagccccgtc attttcgtat 2020141 acgctttatt gattagcagg ccgatgccgt tttcatcaac gacagaaatc gcctcatcgg 2020201 aggattgaat aattgcctcc agcatcgtac ggacctgctt taagttggtc acttcctctg 2020261 ccagctcgac cgcatcagtg atatctttaa acacacaaag agccccgagc agacgtccgc 2020321 cttcatcaat aatcggcagt cttgtggtca caatttgcaa atgatcgcct aacagctgct 2020381 tctggttgta ttcaggcact cttgttttta aaatccgcgg catcttagtg ctcggaatca 2020441 cttcttttat tgggcgccca atgacttcct cacgtttttt tccgaccatt ttttcggcca 2020501 tatggttaaa gagaatgatt tcttcattga tatcaataaa aatcattcca tcatgggtgg 2020561 aattaaaaat tctgtcatat ttataggttt gctcttttag catttgaatc aggtgctgct 2020621 tttcttccat cagctgaaaa acgatgtatg ccatttttcc cggcatgaca atggtatctt 2020681 catgctttct ttgaaggagc tcgtcaaaca cggcttgatc gccggtagta tgaatgacga 2020741 tatccggttt ttgttgtatg taaggtttcc aatcagatga tacggcaatc ccatactgtt 2020801 ctgcttcttt caatcccggc gcctcggggt ctttgtcaac tacggcaatg atatctatga 2020861 tggctgtttt aatcagaata tgtaataacg ccgttcccct tttgccggca cctactatca 2020921 gtaccttttg catcccgata cccctttgta tgaaaaaatt tgcacaccta tttattccgt 2020981 tgcaataatt tgcacaaccc tatgttacca cgttttcttc tcttgacaaa atattttttc 2021041 cgctggacaa taaaggaaat gaaaagataa aggggttttc tgaagatgag ccgacttctt 2021101 gcgcttttaa tattagtcat ccccggggct atttctgctt taggcattaa actgatgaga 2021161 gatacacttt tcggccatac aatcaagcca ttttcagctc tttggctcca agggttgtca 2021221 ggattcatct tttttgcgat cggcctctat gtgctggccg ggttcatttt atacagagac 2021281 agaaaacgca atcaagtcag cccgcgattc agaaaacgat agctgaaaaa aagccggaga 2021341 atgctccggc tttttttgtt gcattattcg tcaggcaaaa cggtcttggc aatcgttttg 2021401 tctaacgctt catagtcata ataagaaatc gtatcgtaca gttcttttcg tgtctgcata 2021461 tcatgaagtc cttctttttg tgagccgtgc tccttcatca aaccaaacat ccgctcacaa 2021521 gcttttgccg ccgctcgaag cgaggtgaca ggatatatca ccatgtgaaa ccccatatct 2021581 tcgaattcat cggcacgata atatggcgtt ttcccaaatt cagtcatatt cgcaaggagc 2021641 ggaacgggga tacgctcagc aaactggcgg aattcattct ccgcctgtag cgcttccggg 2021701 aaaattgcgt ccgctcccgc ctcaatgtaa gcctctgaac gttttattgc ggcatcaagc 2021761 ccttcctgcg ccctggcatc agtacgggca acaacaataa gggagggtgc cgcttgttta 2021821 atggctttta ttttttgcgc catttccttt atcggaacta gctgtttgcc atttaaatgt 2021881 ccgcattttt ttgggagctg ctggtcttcc atttgaacgg ctgctaccct ggcttcaagc 2021941 atctcccggg ctgttcgggc ggcatttaag acaccgccaa atcccgtatc gatatccaca 2022001 agcaaaggca gatcagctgc acgcacaaga tctttggccc gttcagctat ctctgccgat 2022061 gtgatgatcc ctaaatcagg cagccccctg ctggctgtat aggcagcacc ggacaaataa 2022121 atagcagaaa aaccggcttc tttcgcaagc aaagcggcca tcccgtcatg ggcgccggga 2022181 atttgaagaa tgtccggtgc tgacatcagc ttgcggaaac gcccggcaag ctcctcttgt 2022241 gacgattgct tattgacgat ccacgacatg aaacaaaatc ccccttttac atgcagaaca 2022301 tgtctacgaa ttcatttacg cgcatcgttt gtaatgtctc atagctggta cagcgctcat 2022361 aaatgtgttt gtgctgttta tcaggaaaat gggttttgag attgtcagaa aacttttcca 2022421 gcagtttcgg cactgcttcc tctcttcgaa aacgatggcc gaggggaaac tcacattcca 2022481 ccatttccgt gctcgttcca tctttaaaat gaacctgaac ggcatttgag atggagcgtt 2022541 tatcaggctt caaataatcc tcggtatatg ttttattttc agtcacttcc attttatcac 2022601 gaagtttatc tattctcgga tcattcgctg tttcagcttc ataatgctgt gcggtgatat 2022661 caccaaaaag caaaccgatt gctgtaatgt attggaggca gtgatcacgg tctgccggat 2022721 tgtggagcgg gcctttttta tcaatgattc ggatagctga ttcatgcgtt ctgatgacaa 2022781 ctcggtcaat ctcgtcaatc cggttcttta cctgcgggtg aagaatgacg gcggactccg 2022841 ccgctgtctg ggcgtgaaat tccgcaggat aagacacttt aaataacaca ttttccatga 2022901 cataagcgtc gagcggacgg gcaagcttga tctctttctt attgaataaa acgtcttgga 2022961 acccccaacc cggtgcactc aaggctgtcg gataacccat ttcccctttt aacgacatca 2023021 gcgccaaatg aacacctctg ctcgttgcat ctcctgccgc ccatgattta cgcgagcctg 2023081 tattcggtga atggcggtat gtcctcaatg ctgcattgtc aatccatgca ttcgaaagcg 2023141 catttttgat ttcttctctt ccgccgccca aaagctttgc tgcaacagca gttgtcgcaa 2023201 ctttgacaaa cagcacatgg tcaaggccaa ctcgatttaa gctgttttct aacgccagca 2023261 caccttggat ctcgtgtgct ttgatcatca tctcaagtac gtcgcgtacc gttaacggct 2023321 cttttccttc agacagcctc actcttgata cataatcagc agcggcaagg attcctccca 2023381 agttatcgga tggatgcccc cactccgccg ccagccacgt atcgttgtaa tcgagccagc 2023441 gaatcatgca gccaatatta aacgctgccc tcacaggatc gagaacatat gacgttcccg 2023501 gcactttgct tccattcggc acagtcgttc ctggaacaat cgggccaagc agctttgtgc 2023561 attccggata ccgtagcgcc aagattccgc agcccagggt atccagcaat acatgccccg 2023621 ctgttgtata cgcttcggca ctagtaatct ctttctcaag cacatagtct gtgatttctt 2023681 cgataacacg atccgttttc ggcattctac cagctccttt catgattttg tttgatatcg 2023741 cgggcccatg taactgacac ggggacggaa gagccgatta ttggcatgct gttcgatcac 2023801 atgggcgcat aaaccggacg ttctcgcgct gaaaaagatc ggcgtatata aaggaatcgg 2023861 tatgccgagc atccaataca ctggggcagc atagtaatcc aaattcgggt aaagcccttt 2023921 ttccttctcc atcagccgct cacccgcttc gcacatctca tataaacgat ggtcaccggc 2023981 tttatcgcat aattgctgca gcgcctcttt catcatgagt gctctcgggt ccattttttt 2024041 catatacacc cggtggccga agcccatgat tttttctttt cttttcagtt ttgtttgcaa 2024101 aagctgctca aaatcagatg tcgtttttgc ctccaaaagc aaatacatca cagcttcgtt 2024161 tgctcctccg tgaagattcc ctttcaggga agcgacagcc ccagtcaaag ccccataaag 2024221 atctgaatgt gtagatgcaa tgaccctggc cgcaaaggtt gaattcggca tctcatgctc 2024281 actgtacagg acgagcgacc ggtcaaaaat ctgttcttcc aatgaagacg gcaatttccc 2024341 tgtcatcatg tagagaaaat tcgcactgta ggatagggtt tgaagcggaa gaatcggttc 2024401 tttcttatta atgatcctgt agctggcagc agtgagggca ggcattttcc caagaagctg 2024461 ataggcgcgt tctttgtttg cggaaggaga ccgatcatca atttgccgat catagccagc 2024521 aagtgccgac aggccggtac gcagaccatc cattggatga gtgtcctcag ggagcagctc 2024581 aagcagacgg agatgatcag caggcaggct tgaggcactg tttattttac gttccagcgt 2024641 ttccatttca ctttcttctg gcagcctgcc ctccagcaat aaatggacaa gctccagata 2024701 gctttttgtt tcagaaagtt ctattaaatc atagcctctt atcaaaatct ggctggactg 2024761 cgtgtcaaga taagaaatat gagtttctgc cgcaatcaca ccgtccaacc ctggagaata 2024821 atgctgtttc tcctccatat cctcaacctc cgtttttgcg ttttttgtct atcaggttcc 2024881 gccaagcaaa tacttggaaa taatcagtct ttgaatctcg ttcgtccctt cataaatttg 2024941 cgtcaccttt gcatcgcgaa gcaggcgctc aactggataa tccttcatat agccatatcc 2025001 cccataaatt tgaacggcgt ctaacgccgc ctttacggct gcatcggaag caaattgttt 2025061 agccatagac gcttcttttc cacagtttag gccgcggtta tgaaggtctg cagcgtggta 2025121 gacaagatgt cttgccgcct cagctctagt cgccatatca gccagcttaa atgatatgcc 2025181 ttgattggct gcaatcggcc ttccaaattg cactcgctgc ttcgcataat caacggcatg 2025241 ctcaagagcc gcctctgcaa ttccgagggc ctgtgccgca atgccgatcc ggccgacatt 2025301 taaattcgcc atggcaatgt gaaagccatc cccctctttg ccaagcaaat tggcttcagg 2025361 cacttctgca ttatcaaaaa tcagttccgt agtattggag ccataaagcc ccagctttct 2025421 ttcttttttt ccaacggtaa aaccgggtgt gtttttttca acaataaaag ccgaaatccc 2025481 gtgcctgcct tgatctggag ctgttaaagc aaatgtgata tagatatcag ctgctccgcc 2025541 attcgttatg aatattttcg atccgtttaa taggtatttg ccgttctttt tgattgctgt 2025601 tgtgcggagg ctcccggcat ccgaccccga gtgaggctcc gttagtgcaa atgcgcccaa 2025661 atggtctcct gacgcgagat ttggtatata tttcatcttc tgttcttcgt tgccgaaata 2025721 cagaatcgga ttcgtgccga ctgaggtatg aacggagaga atcacgccga cagccgcgct 2025781 gattctagaa atctcatgaa ttgccaaaat ataagaaaca acgtccgctc cagcaccgcc 2025841 gtattgttcc ggcaccggta ttcccatcag tccgtgttta cccatttttt tgatcagctg 2025901 aaagggaaat tcgtccgttt tctccatgat ttccgcagcg ggagcaattt cttttcgtgc 2025961 aaaatcacgc accatttttc gcatcatgac ttgctcttgg gttacatgca actcggccac 2026021 ccccggatgg aatagacttc aggaagtctt ctcctcatag tcataaaaac cgcgtccgct 2026081 ctttttgcca agccagcctg ctttgacata cttgcggagc agcgggcaag gacggtattt 2026141 ggaatcgcca aggcctgagt gaaggacttc cataattgat aaacacgtat ccagtccgat 2026201 aaaatccgct aatgcaagcg gacccatcgg atgattcatg cccagcttca tcacttcatc 2026261 tattgcctcc ggcttcgcca ctccctcata cacgcaatag atggcttcat taatcattgg 2026321 aagaagcaca cggttggaaa caaacccagg aaaatcattg acttctaccg ctgttttccc 2026381 catcttttcc gctaatgcca taacatctaa ggccgtttct tctgatgtag ccaagcctcg 2026441 aatcacttct accagcttca ttacagggac gggattcata aaatgcatgc caataacccg 2026501 ttgaggccgg tttgttacag cagcgatttc tgtaataggc aaggaagatg tattgctggc 2026561 caaaatcgta tgaggcgggc aaatgcgatc aagtgtttta aacatctcag tttttgccgc 2026621 catgttttct gcgatagcct caatcacaat gtccgcatgc tctgcctcct caagtgtttg 2026681 agaaatcgaa atgcggttga ttacgctctt cacttccgtc tcggtccttt ttcctttctc 2026741 agcatcacgg gccagctgtt tcttcagccg tttcaatcct gcctccgcgg cctctggatt 2026801 cacatcatac atccgcacat aaaagcccgc gtcggcggct gtttgagcaa ttccgctccc 2026861 catctgacct gcgccagcta ccatgatttg tttgatttcc attcaaatcc cctttttcat 2026921 catgttttaa tgaacctgca ctaagacggc gtctccctgt gctgccccgc tgcaaatagc 2026981 ggcaacgccc agaccccctc cccgtcgctt taattcataa acaagcgtca tgagaattct 2027041 cgcaccgctc gcgccgatcg ggtggccgag cgcgatcgca ccgccattca catttacttt 2027101 ttcaagatcg aaacctacga ttttttcaca tgtcaaaaca actgaagcaa aagcttcatt 2027161 tacttcaaac aagtcaatat cttggacagt taaaccattc tttttcagga gcttgttaat 2027221 agcaaaccct ggcgctgccg ccagctcgtg cgctggcatt cccgtagttg aaaaaccaag 2027281 aattgtagcc agaggccgtt tgccaagctc agcagctttt tcctcagaca tcagcacgaa 2027341 cgcgccggct ccgtcattga ctccaggagc attgccggct gtgatagaac cgtcacttgc 2027401 ataaatcgga gcaagttttg cgagctgatc cagacttgtg tcacggcgaa tcgcttcatc 2027461 tttatcaaca acgtttggtt ttccttttcg accgatccag ttgacgggaa caatttcatc 2027521 ctgaaacttc ccttcatcgg cggccttagc tgcccttgca tgacttctca acgcccattc 2027581 gtcctgctct cttcgtgaga ttgcatattc cttggcagct gtatttccgt gaacagccat 2027641 gtgcacctcg tcaaatgcgc acgttaatcc gtcatacacc attaagtccc taagctcgcc 2027701 gtcccccatc cgtgctcccc agcgcccggc gggaacggca tacggaatat tgctcatgct 2027761 ttccatcccc cccgcaacaa gtatgtccgc atcctgcgcc cgaatcattt gatcacataa 2027821 agtgacagcg cgaaggccgg aagcacagac tttattcagt gtttctgacg gcacactcca 2027881 aggcattccc gccagacggg cagcttgacg ggaaggtatc tgccctgagc cggcctggac 2027941 aaccatgccc atgacgtttc cttctacatc atctccagag actccagcct gttgcagcgc 2028001 ctccttcatc acaatgcccc caagctcagc agctttcacc tctttcaaaa ctccgccgaa 2028061 tttgccaaat ggagttcttg cagcacttac aatgactgtt ttcctcatgg tttcacctca 2028121 ttcagaagat agacagcgct tacaatttct agttgtcttc tatgaatgta tgctttgaaa 2028181 cgggcatgaa tgaatgaaaa aagaaggctg cgtcaaacag cctccttcta acaactattc 2028241 atttttcagc aatgccgaag ccttttctgg aaagtcggta aacatgccgt ctgctcccgc 2028301 ttcaatgaga cgcttcatat cttccggacg attgactgta tacggcctta ccttaatcaa 2028361 accgttcctc attttcttca gtacttcatc tgtgacccct gggctgttta tcttcgggtg 2028421 atagccggaa gccggaatag acgcgatata tcgatctgcc tgataaagca catctgaagt 2028481 taatactgcc cgttcgatat gcggtgcaag ccgggcgcac agcgccaagc tgtcatgatt 2028541 aaacgtggat aggatgactc tgtcctctac attaaatcgc ttcactgcct ccagcacttt 2028601 ttcttccatt ccctcatagc ggatcacgct gttttttaat tcaatgttga tgagaaaatc 2028661 cttttttacc gcccacgaga gcacatcttc tagcagcggc acttttatat cgctgtacgc 2028721 ttgatcgtga ccagcggccg cattcgcagt ctttacctca tcataggctg tatccttcac 2028781 gaatccttta agtgatgtcg tgcgattaag tctttcatca tgaattacaa caatgcgtcc 2028841 gtctttcgtc agctgtacat caagctctat cccatccgct ccggcttcaa ttcctttttc 2028901 aaatgcaagc attgtatttt cgggaaattg acctgatgcc ccccggtggg caaaaatctt 2028961 tgtcatcgtt tcacctcaaa ccctaaagtt ttctccatta tacttatttt gtcggctcca 2029021 ctctaggatt aaggctgtat caatctactg atcataataa gaatcaatgc cattgacaat 2029081 cgcatctgcg gccttttgct ggtattcttc acttcccagc ttgtccgcgt cagagctgtt 2029141 cgtgataaac ccaagctccg ccaacacact tggcatttgt gaatatgtaa tgacgtaaaa 2029201 gtctgattct ttcacgcccc tgtctctcgt ttgtaaggaa gaaacgagct gtgactgaat 2029261 atcggatgcc agacgccggc tgttctcccc ttcataatca gattgaaaat acgtttctgt 2029321 tcctgaagct gaagcaaccc ctgaattcac atgaatgctg acaaaaaggt cagcctgatt 2029381 ggcacttgcc ttagccactc tttcctccaa ggtcagaaaa tgatcgtcag accgggatgc 2029441 aacaggattg gctccctcct cttttagttt gtctgtcaca tgctctgaga cagccaaatt 2029501 aatatccttt tcaaagagcc cgtttccgac cgctccactg tcttcaccgc cgtgtccggc 2029561 atcaatatac actgttttcc cttctatcgg ctctgctgcc tgtgcacaag gcgcgagcgt 2029621 caaagccaat ccgcacagcg ccaagctcct ccataacatt ctcaacttac tccctccggt 2029681 cacgagttct ttcgcagctg aatatcttcc agctgtaaag ttccattatc cttctttgta 2029741 tatttcacca ggacatgtgt ctgatctggc agtgattcac attcatcacg tttatccttc 2029801 ggaacttgta tcatggtttc ttctccatta agagaaaccg caatcgtatg aggatcagcc 2029861 gagccaatgt attttccctc ttcggtaaac ctcggcactg agtcatccgc acttgcaaca 2029921 ctgcaccccg aaagaaagag cgcagtaaac agcaaaagaa ccgtttgttt cacatgacca 2029981 cctcttcctg atgtttggct tttatctttg accagaatgg agaatttgta aagacaacgc 2030041 gaatgcaggc gagcaagttc catgattttc aaaagggcta tacgacccga tcatttcctg 2030101 ttgttagaaa gataacgagc agatttgtct atgaggatgg ctctaattga ggcgccaatt 2030161 agaaaaaatt agcggaaaga agcaactttt tattcatttt aaaaaatttg agaatagggt 2030221 gagcaaatcg tttgacgggt gggtcagcca agcgtaacct tttaaaggat atttacttta 2030281 ttgaaagaag ttaaagccat gaaaaaattc gttctgctgc tggcggcagc tgtcatcaca 2030341 tgctccatcg gccaccaaat cagtggcggc tacaaaggcc ccgaaaaaga gcggccaaaa 2030401 catcactctg cactcaagat attcagtcgg taaagcagat caattgcatt aatttttaca 2030461 tataggctag aatatgtgcg aatccaaacg aaagaagatg atcaaatgaa tcctaagtat 2030521 aagccacttt ttgaaccatt tacgtttaaa agcggcgtta caatcaacaa ccggatcgca 2030581 gtagcaccga tgactcatta cgcttctaat gaagacggta caatatctga agcggagctc 2030641 gactacatca tcccccgttc aaaagagatg ggaatggtga ttacagcctg cgcaaatgtt 2030701 acaccggacg gaaaagcatt ccccgggcag ccggccatcc atgacgattc caacattcca 2030761 ggtttaaaaa agttagcaca agccattcag gcacaaggcg ctaaagctgt tgtacaaatt 2030821 catcacggcg gtattgagtg cccgtctgag ctcgttcctc aacaggatgt tgtggggcca 2030881 agtgacgtgt ttgataacgg caaacaaatt gctcgcgcat taacagaaga agaagtggaa 2030941 aacattgtga aggcgtttgg agaagcgaca agacgcgcca ttgaagccgg ctttgacggt 2031001 gtcgaaattc acggtgcaaa cggctactta attcagcagt tttattctcc gaaaaccaac 2031061 cagcgcacgg atcgctgggg aggaagcgat gaaaaacgat tagccttccc gctcgctatt 2031121 gtcgatgaag tgaaaaaagc cgcttcagaa catgcgaagg gtgcattctt agtcggctac 2031181 cgcctgtctc cggaagaacc tgagacaccg ggattgacaa tgactgaaac ttatacgctt 2031241 gttgatgctt taggggataa agaattggat tatcttcata tctcactgat ggacgtgaac 2031301 tcaaaagcgc gccgcggtgc agatccgact cgcacacgca tggacttatt gaatgaacgt 2031361 gtcggaaaca aagtgccgct gatcgccgtc ggttccatcc attccgctga tgacgcgctt 2031421 gccgtcatcg aaaacggtat tccactggtc gctatgggac gcgaaattct agttgaccct 2031481 aactggacgg taaaagtaaa agaaggccgt gaaaagcaaa tcgaaacagt gatcaaaggc 2031541 acagataaag aaaaatatca tttgcctgaa ccgctatggc aagcaattgt gaacacacaa 2031601 ggctgggtgc cttataaaga ttaatgtgca aagactgccg aaacgattcg gcagtctttt 2031661 ttccctttat ataaatagtt tgtgtacaca tctaaacagc aaaagaaaga gctccccacc 2031721 aacttcgaaa agaaaatcca ggaaaaaccc ctcacgcttt cttgcttttt tctttttcat 2031781 tcgtacgtct cctttttaca tgaatacgcc ttacttacga ttttgcagga gaaaggtttc 2031841 attttataac ggacacatct agggtcgatc atgcttcgtg atcctataag atgtatgaat 2031901 ggaccaagag tgcaggtaat accgccattt gctttcctta cttttcaaac ctatccttta 2031961 ctatatgcgg atacttaata ttcttctccc atactacaaa tgtccccaaa acaaaacgcc 2032021 tcctatttat cagcgcaaac taataaataa aagacgtttg atttaatgac cacttaataa 2032081 gctcatgttt aagaagcctt atgctctaac ctcagcttat ccgcaaccat tgcaatgaat 2032141 tcactgttgg taggtttagc ttttgtcatg ctgacagtat aaccaaacaa cgaggaaatg 2032201 gaatcaatgt ttcctctgct ccatgccact tcaattgcat ggcggatcgc tctttctaca 2032261 cggcttgcgg ttgtgttaaa ttttttggcg atgtccggat agaggacttt tgtaatgctg 2032321 ccgagcaatt cgatgtcatt gtataccatt gagattgctt cgcgcagata gagatagcct 2032381 ttaatatggg ctgggacgcc gatttcatgg ataatgcttg tgatgctcgc gtcgagattt 2032441 ttcttctttg gttcaggctg gctgctgcgt ataatactgc tttgcgatga tggcgcacga 2032501 tgcgtcacac tgctggcatt tccgctgacc tggcggatat ggccgacaag gttttccata 2032561 tcaaacggtt tgagaataaa gtaggacgcg cctaaatcga cggccttttt cgtgacatct 2032621 tcctgcccaa aggctgtcag cataatgaca ttcggctgtt ttttcagatc tgattccctc 2032681 agcctctcta aaaccgcaag tccgtctaga tgcggcataa taatatctaa tacgagcaca 2032741 tcgggatctt tttctttaaa cagcgacagg cattcctgtc cgttataagc aacgccgatc 2032801 acttccatgt cttcctgtcc ttctatatat tcacttaaca ggcttaccag ctctcgatta 2032861 tcatcagcaa cacaaacttt aattttctcc acgtttcttc ctccccaaat gtagttaaca 2032921 ggattcaccc ttgctacatg tttacattcg acaaaaccgc tatataccct ctaaaaaaat 2032981 cataatcacc aatattagtg gcatatcttt gttattctat gtttttctct gtttttcgac 2033041 taaaaatgaa atttgacaaa caaggaaacg tgaatttgtc gaaaaatctt cttttgtata 2033101 ttttaccgta tgtattctga gaagtgaaga gggatcagga tatactgatg aacgaatgga 2033161 tgtgcacgaa aaaaataagc tgcgcttctc gcgcagctta cccagttgtt ttgacttgat 2033221 ccgcttgttt taaaagttct ttcgcatggc gtttcgttaa gtcggttact tcgacacctg 2033281 caatcatgcg cccgatttcc gctacctttt cctgcttaga gagcggcttg acacgtgtcg 2033341 tcgttctgcc gtcttttaac tccttcgcaa tataaagatg cgtatcggcc atggcagcca 2033401 cctgaggcag gtgtgtaatg cacagcactt gtgatcctat tgacacctta tggatcttct 2033461 cagcaattgc ctgtgcgacc ctgccgctta caccggtatc aacctcgtca aaaatgatcg 2033521 atgtcacatc ctgttgtgag gaaaaaatgc tttttatggc aagcatcacc cgtgacagct 2033581 ctccacctga agcgactttc gaaagggatt tcagcggctc gcctgtattg gttgaaatta 2033641 aaaacttcac caggtcaatc ccttgttcag tcagctgaac gggctggccg tttacaagcg 2033701 gcgcctcttc attgcgtgac gctgttctga ccttaaattc cgtatcaaaa gttgattttt 2033761 ccatgtacag gctttttaat tcccgatgaa tctcatcagc cagctttttc gcccatgttt 2033821 ttcggatttg tgacacattt gccgcttcca ctgcgacatc tttgccgacg gagtcaagct 2033881 cctttttcaa gctttgaagg tggctgtccc tgttttcaat ttggtcaatc tcttcttcaa 2033941 ttttagaagc atattccaaa atgtcttcaa cagtggcacc gtattttcgt ttcagctgtt 2034001 tgatttcatt aagtcgcgtc tcaatatagt tcaggcgttc cggatcaaat tcaagctcat 2034061 ccagcatatt tctcatctga aatgtggcat cctcaagcaa atagtaggag ttcgaaacac 2034121 tttcagacat ttttttcagc ggttcgttta tatcagatat atcttcaagc tgcgctgatg 2034181 ccattccaac ccagtccaat ccgccctgct cactgcgaag cgcgttatat gcattttgca 2034241 gcgactcata tatcttctca aagtttgaaa tttgctggcg ctcttcttgg agctgttcat 2034301 cttcgttaag ctcaagcttt gccgattcga tttcttcgag ctgaaattga ataagatcaa 2034361 gacgatgggc catttcctgt tcgctttcag aaagctgctt aagctttttg agcagcttca 2034421 cataccgctg gtacccttcc tgatacgttt tgagcgcgct ttccacttcg gccccggcaa 2034481 acttgtccaa aagctggaga tgattttcgt cttccattaa cagctggtta tcgtgctgcc 2034541 cgtgaatatc taataaaagc ctgccgatct ctcttagtga agcaatcgtg acaagcttgc 2034601 cattgacacg gcaaacgctt ttcccgctcg tgctgatatc ccttctcatg acgatcattt 2034661 cgtctgaaac gtcgattccc tgctcagcgc atacgcctaa aacaggatgg ccgctctcca 2034721 acagaaacag cccttcaagt tcggcttttg cttccccata tctaacaaat tcagatgatc 2034781 cgcggcctcc gactaaaaga gaaatggcat ctatgatgat ggatttgccg gctccggttt 2034841 ctcctgttaa aaccgtaagc ccgcgttcaa aagaaaccgt cagttcctca ataatggcaa 2034901 agtttttaat cgatagttca gctaacaaac agcattacac ctcttatctt tgttagattt 2034961 tctgttacag cagttcaagg agcctgtttt ttacgccttc tgtatcttca ggagtccggc 2035021 aaataattaa aatcgtatca tctccgcaaa tggtccccat catttcatcc cagtccaaat 2035081 tgtccatcag cgccccgatt gcctgggcat tgcccggcat cgttttcagc acaatcatat 2035141 ggcttgctga gtctattttc acaaatgcgt ccatcaatgc ccgctttagc tttgacagcg 2035201 gattgaaacg ctggtccgcc ggaagactgt atttgtaaga accattattt gtaggcactt 2035261 ttacaaggtg aagttcttta atatcccgtg ataccgtggc ctgcgttact ttgtatccat 2035321 cctgctttag catgtcgacc aattcatcct gcgtttcgat ttcattgctt gtaatgatct 2035381 ctctgatttt aatatgcctc tggcctttgt tcatgtaagc acctctattt ccaagcttat 2035441 ctgttctttt atgttatatg attctctgca cattgtacat gaatgcagaa aaaaggaata 2035501 atagcgccct attattccgg tacatctgct tttttttctt ttaacgtctt atgtgcttct 2035561 tctacaacgc gcatgatctc ttcttccggc agttcctggc cttcctgtcc ctctcccggc 2035621 caatgcaaat gaaggagaaa ctcaatattt ccgtctcctc ccgtgattgg agaaaatgac 2035681 aagcctttac agatatagcc ttcagcggca gaaaaactga tcattcgctt gagcacatca 2035741 gcatgcactt taggatctct aacaatccct tttttgccga cggattcccg tcccgcttca 2035801 aactgaggct taactaaagc catgcagtcg ctgcccggta cgagcaaagt ccttaggaca 2035861 ggcaggatga gccgcagtga aataaaggac acatcaattg tggcaaactc cggcatgccc 2035921 tttgtaaagt ctgccggtgt tgcataacga aagttcgtcc gttccatcac gacgacccgt 2035981 tcatcctgtc taagcttcca tgcaagctga ttatagccta catccacagc gtatgactgt 2036041 ttagctccat tttgcaaagc gcagtccgta aaaccgccgg tggaggagcc aatatcaatc 2036101 ataattttat ctttgacaga gacgggaaat tccttcaacg ctttttcgag ctttaagccg 2036161 cccctgctca catacctcag cgggtttcct ttgacagtta acggaaggtc gcggtcaatt 2036221 ttttctccag gcttgtccaa gcggttttcg tttgaataga cgatccccgc cataatggct 2036281 cttttggctt tttcacgcgt ttccgccagc cctctttcca ctaataatac atctaatcgt 2036341 tctttctttg acgtcatgat ccaattcctt tgtgtgtctt tggtggcatc agtaatctaa 2036401 tacgatttgc cacctgctgt tttgtcagtc caatttcctc aagaagcgct gttacacttc 2036461 cgtgttcaat aaaccgatca ggtataccca ttctgtcaat cggagtatga tattcacctt 2036521 gatcatgagc gaattctaaa atcgagcttc cgaaaccgcc ttctaagacc gcttcttcaa 2036581 ttgttaaaat tggcaagcct tcttttagga tactcttcat catcttttca tcaatcggct 2036641 taataaaacg cgcattcaca acgcgcacgg aaaggccttc tttctgcagc tcttcggctg 2036701 cttcaatcgc catttcgatt gttgtgccga atgttaagat gacagcatcg ttccctggac 2036761 gcagcacctc ccacgtaccg atcggaatcg ttttcaactg ttcatccatt tttacgccga 2036821 gtccgtttcc gcgcggaaaa cgcattgcta tcgggccttc gtcatagcta agtgctgtat 2036881 gaaccatgtg ctggccttca ttttcgtctt tcggcatcat taagaccatg tttggaatgt 2036941 ggcgcataaa cgcaatatca aacacgcctt gatgtgtctc tccatcagcg ccaacgagtc 2037001 cagcacggtc aattccaata aacacattag cgttttggcg gcagatgtca tgaacaactt 2037061 ggtcatatgc cctttgcagg aaggttgagt aaatcgccaa aaacggcttc ataccctgca 2037121 ttgccatagc tgcagccatt gttgcggcat gctgttctgc gattcctacg tcgaacatcc 2037181 ggtcagggaa ttcctttgcg aagccttcaa gctttgaacc gacaggcata gccggcgtaa 2037241 tggctacaat gcgtccgtcc tcgcgcgcca ttcgctgcac agttccgctg acaagaccgc 2037301 tccacgaagg agctgcggct ttcggcttta caaagtcacc ggtattaatt ttatatggtc 2037361 cggtaccatg ccatgtccca atcgtatcgg tctcagccgg tttgtacccc ttcccttttt 2037421 tcgtaatgac gtgcagaaga acagggcctt tcgttttttt ggcgtattga agattctcaa 2037481 tcagctcatg ataagaatgt ccgtccactg ggcccaaata cgtaaaaccg agctcctcga 2037541 aaaacattcc ggagacgagc atgtatttca ggctgtcttt gacccgttcc gccgtggcgg 2037601 caagcttgcc cccaactgcc ggaatctttt taaataagta ttcaagctca tctttgaccc 2037661 actggtattt ccccgcagtg cggagccgtc cgagcataga gtgaatggca ccgacgtttg 2037721 gcgcaatact catttcatta tcattaagga tgacaatcat gtcttttttc tcgtcgccga 2037781 tgtggttaag ggcttcgagc gccataccgc cggtcagcgc gccgtcacca atgatcggaa 2037841 taatatattc atccgttcct ttaatatcac gggcagctgc cattcccatc gcgcctgaca 2037901 gagaagtcga gctgtgcccg gtttcccaaa catcgtgctc gctttcactc cgctttggaa 2037961 atccgcaaag ccctttgtac tggcgaagcg tcgcaaattc ttttccgcgt cctgtcagca 2038021 gcttatggac atacgactga tggcctacat cccataaaaa tttgtctttc gggctgttaa 2038081 attccttatg cagggcaaca gtaagctcta cgacacctaa gtttgggccg atgtggccgc 2038141 cggaagcgga taaacttgta attaaaaact gacggatttc atcacttaat ttctctaatt 2038201 catcaatgga catgtttttt aaaaacgacg ggtcctgtat tgataaaaga tccaaagcgg 2038261 atcaactcac tttcagcatg aatttctgca atgatacatg tcttttgcat gccgagctga 2038321 caataatctc agacataaaa aaagacaaac gcgcttttcc ttttcatttt tcatataaac 2038381 tgcttacatt ttaccatacc tcgtgcagcc gcttcaaatt aggatcgttt tagtgatctc 2038441 ttgccgcaat taaatcacaa agctcatata aaaggtcttt ttgaagagag agtccgccga 2038501 tcaatcgctt cgcctctttt atatgaacat ccaatttatg tttggcccct tccaatgaaa 2038561 gaagcgacgg gtatgtcgat ttgtcatttg tggtatccga gccgacacgt ttgccgattt 2038621 tctcttcact gccttctaaa tctaaaatat cgtctctgat ttgaaatccg attccaatgt 2038681 ggctgctgaa ggtacgcagt gtttcaatgt cttcctcagg cgcatcagcc aaaatagcac 2038741 cggcgattac acaaaagcca aggagcttgg cagttttccg ttcatgaatg gattcgagct 2038801 cttcaagcgt gacttgtcgg ttttccgctt ccatatcagc tacttgccca ccgaccatgc 2038861 cttcggtgcc tgccgctgaa atcagttcat tcacaagccg caggcgcttt tctgctgaca 2038921 cctcgtctga cacgtgggag gtaatcagct taaagctttc tgtgagcagc ccgtcacccg 2038981 ctaatactgc cgtcgcttca ccaaacactt tatggtttgt cggcttcccg cggcgcaaat 2039041 cgtcatcatc catgcatgga agatcatcat gaattaacga atacgtgtga atcatttcga 2039101 cagcacagcc caccggaatg ccgtcttttt cgctttttcc atatgcattt aaaacagcca 2039161 gtacaatcag aggccgcaac cgctttccgc cggcctgtag agaatatagc atagatttct 2039221 ttaatgagtc cggcatatca agcttttctg tatagacaga aagctgattt tcaattgttt 2039281 ttttccggtc cgccagaaag ctcgttaatt tatttgtcac cttcgtcttc ctcctgaaca 2039341 ctgaaaggtg ccagttcgcc gtcttctttt aaaatgaagt ccatttgctt ttcgactttt 2039401 tgcagctttt catggcacat ttttgacaga gccatgcctt cttggaaata gttaatggct 2039461 tgctctagag gcacatctcc ctcttcaagc tttgatacaa tgctctcaag ccctttcatc 2039521 gcttcttcaa atgtcatgtt ttcatttttt ttcacgtctg tcatttttct tcccctctct 2039581 tttctaatac ttcacaggtc agcacgccat ccttcagctt gatttcaagc cggtcctgct 2039641 cttctatttg actgacactt ttaatgagtt tatcttcttt ataagccaag ctgtatcctc 2039701 tttccatcac ttgaagagga cttagtgcat tcagcttgcc aagaacggtt tgaaattggg 2039761 aatgcagctg cttcatttgg atattcatat tttttctcag ctgatttgtt tgttcctggt 2039821 atcgtgttct cgcttgtttc agctgttcat gaggatgcaa tgcctctaat ctgtacgttt 2039881 cacgctccag ctgtctgctt ttccgatcta aaagagcggt cagctgtgct tgaaactgct 2039941 ggtacgcgag gtcaaactgc tgctcttttt gcgcatacaa acgctttgga aaacgaaagg 2040001 cataggacga ttgcagcgtt tgtatccgtt cttttttctg gccgagatgc tgctgcattg 2040061 ctcttgtcat tctgacttcc gctgtttttg tccgttcgat taaatcagtg gtatgaggca 2040121 cagcaatctc agctgctcct gtcggcgtcg cagctctgat atcggcgaca aaatcactaa 2040181 tcgtaaaatc cgtctcatgt ccgactgccg atataatcgg aatattggaa gcaaagatgg 2040241 cgcgtgctac aatttcttca ttgaatgccc acagttcttc tatcgaaccg ccgcctctcc 2040301 cgacaattaa tacgtcgcaa atctcttttt catttgcctc ttcaatgcgc gtaacgatgg 2040361 atctgctcgc attttcacct tgtacgagcg ctggaagaac aatgactttt acaaggggat 2040421 atcttctttt tagagttgta ataacgtctc tgacagcggc acccgttgga gatgtcacaa 2040481 ccccgattgt ggctggaaat gcggggattt gttttttgta gcggtcgtca aataaacctt 2040541 ctccggcaag cttctttttt aattcttcgt acgctaaata aagcgctcca accccgtcag 2040601 gctgcatttc tttggcatat aattgatagt ttccgctcgg ttcatatacg gaaattccgc 2040661 ctctgaccag cactttcatt ccgttttcag gtttaaaagg cagacgctcg ctttgtctcg 2040721 cgaacatcac cgactgcatt cttgcgtttt cgtcttttaa agtgaaataa atatgccctc 2040781 gtgtgtgtat ctttacattc gacaattcgc ctttaatcca aatattttca aggtgaggat 2040841 ctacatcgaa ttttcgtttt atatactttg tcagcgctga gacggtcaca tacgctgctt 2040901 cacccatgtc taaaaactcc tctcctaagc attcctgcac cataactaaa gaaaacccgc 2040961 cctggcttta ggagcctgaa gaagcgggta tcgtgctcat attcaaggcg ggtaaacatt 2041021 tcgcctgtga atatctccaa ttatctatga taacgtacgt ttcgcagatt taacagtatt 2041081 atgcgcaagc atcgtgatgg tcatcggacc tactccgccc ggaaccggcg ttatgaagga 2041141 cgctttttcc tttgcccctt caaattcaac gtctccgcaa agctttccgt tttccagacg 2041201 gttaacgccg acgtcaatga caacagcgcc ctctttgatc tggtctgcac tgatgaagtt 2041261 ggctctgccg actgccacca ccaggatgtc cgcttttttc gtatgttcag taatattttc 2041321 tgttcttgaa tgacagtaag taaccgtcgc gttttcattt aataaaagct ggccgacagg 2041381 tttgccgaca atgttgcttc ggccgactac aacaacctct ttaccggaaa ggtcaatatt 2041441 ggttttcttc aaaagctcaa caattccatg aggcgtgcaa ggaagaaacg tatcttcgcc 2041501 aagcagcatt ttccctacgt ttaacggatg aaaaccgtct acatctttat caggggagat 2041561 acgttcgatc accgcttttt cagaaatatg gtctgggagc ggaagctgaa cgagaatgcc 2041621 atgaaactca gggtcttggt tatattgatc aataatggaa agcagttcag cttctgtgag 2041681 gctgctgtca aattgatcga gcttgaaatt cattcccatt gtttctgccg cttttttctt 2041741 tcctcgcacg taagagtgag aagcaggatc atctccaatc aaaataaccg ccagtccggg 2041801 agtgacgcct tgctttttaa gctcttctac ctcttttgcc aattgttcgc gtttttctct 2041861 agccgtttct tttccgtcga tgattgttgc agtcattttc tttcctccta tgattgttca 2041921 atatcagatt taatgttaga aagaaccccg tttacaaact ttgtcgcttt gtcatcacca 2041981 aaccgttttg ccagctcaat cgcttcgttc atggagacat tcaccggaat gtcttcggca 2042041 tatgccattt catatgctgc caggcgcaaa atcgcacggt caacattggc aatccgatcg 2042101 agcttccaat tcaccagatg cttggagatc atttcatcca gctggtcttg gtgttccaat 2042161 accccgtgta caagctgttc aaagaaagga tctgtttttt cttcatccag tgcgtgttct 2042221 atggcttcat tcactgcaat atcgctgaca tcaatttgaa atagtgcctg caaagctttt 2042281 tctcttgctg ttcttctttt cattttcttt ctcctttgat cctctttatc cgcttgtcgt 2042341 taagccacaa agagatcata acatattttt ttcgtatccg catattgaaa tcaaggtttt 2042401 tttaccctat taccgaatat tttcacacac cttaatatga ttattcggat ttcacgttca 2042461 tgaagaaact cggctatgta agccggcttt cttcatgctt tgaaataaag ggtaacgtgt 2042521 aaaaaaacca aagggccgcc ctccccttgg tttcgtgtta agccatttac atttcttcgt 2042581 cgatttggac ttcttgggct tttgtgtcaa attgaatgcc gacgatgtga atattgatct 2042641 cgttaatcga aagagacgtc atatttaata aggtttgacg aatgttttcc tgaacggatg 2042701 ctgcaacttt cggaatcgaa acgccaaatg taacgacaca gtatacatcg atcgtaattc 2042761 cgtcatccgc caggtcgact ttgacacctt tgccatgatt cactttgcca aagcgctcaa 2042821 cgacgcctgt cgcaaagttt ccgcgcattt cggcaactcc atcaacttct gatgctgcaa 2042881 tgccggcaat gacctcaatg acctccggtg caatctcaac cttacccaaa tgcgtatctt 2042941 cgtgatccat tttaagcaag ctgttgtctt tcattcaatt cacctccgta aaaattatga 2043001 gcccattaca tcatatgttt ctaaaaattt cgtattaaac tctccgctca caaatgtttc 2043061 gtgttcaagc agttttaaat ggaaagggat tgttgtctca atgccttcga tgacgaattc 2043121 gctcaatgcg cgcttcatgc gggcaatcgc ttcatctctc gtttttccgt atgtgattac 2043181 ctttgcaatc atgctgtcat agtacggtgg gatggaatag ccagggtacg cagctgaatc 2043241 gacacggaca ccaagaccgc caggaggcag gtacatttta atttcaccag gtgacggcat 2043301 gaaatttttg cttgggtttt ctgcgttgat tcggcattcg atggcccagc cttcaaattc 2043361 aacatcttct tgcttgaggc tcagttccat tcctgaagcc actttgattt gttccttgat 2043421 caggtcagtt cccgtcacca tttctgtgac tgggtgctcc acctggattc tcgtgttcat 2043481 ttccatgaag taatagcgct gttcattgta gtcatagata aattcaactg ttccagcacc 2043541 tgtatagcca accgctttgg cagcctttac cgctgcatct cccatttgct ccctgatttc 2043601 tgaatcaagg gcaggagatg gtgattcttc caaaagcttt tgcaggcgtc tttggatcga 2043661 gcagtcgcgt tcgcccaaat ggatcgtatt tccgtagtta tcagcaagca cttggatctc 2043721 aacgtggcga aaatcttcta tgtatttttc gatgtataca cctggattcc caaatgcagt 2043781 tgccgcttcc tgctgtgtaa tcttaatgcc attaatcagt tcctcttcag tgcgggcaac 2043841 cctaattcct tttccgcctc cgcctgcggt ggcttttata attacaggat acccaatttc 2043901 attagcaagc gaaaccgctt cttccacatt ttctataatt ccctgtgaac ccggtacgat 2043961 tggcacgccg gcctgtttca tcgtttcccg cgcaacgtct tttgttccca tttttgaaat 2044021 ggcgtcagcg ctcgggccga caaacgtgac attcacttct tcacataatt cagcgaaatc 2044081 agcattttca gctaaaaatc cgtatcccgg atgaatggcg tccgtgccag tcagctttgc 2044141 aacactcaca atatttgtaa cgtttaaata gctgtctttt gatgctttcg gtccgataca 2044201 aaaagcttca tcggccattt gaacatgaag ggcatcttta tcagcttctg aataaacagc 2044261 gacagtctca attccgagct ctctgcaggc tctgatgatt ctgacagcaa tttctcctct 2044321 gttggcgatc aatagctttt taatcatgtt cagtctcctt actccgcttt tacaagaaat 2044381 agaggttgtc cgtattcgac cagctggccg ttttctacta atacttcaac gatttcgcct 2044441 ttcacttctg cttcgatttc gttgaaaagc ttcatcgctt ctacaatgca gacaactgtg 2044501 ttttcattta cttttgaacc ggctgttaca tacgggccag cttccggtga tgaagaagca 2044561 taaaatgttc ctaccattgg tgaagtgatt ttatgcagat tctcatcttg ctttggtgct 2044621 tcttgggcag gtgccgctgc ttgctgcgct tgcggctgaa ctgcctgcgg agcctgtgct 2044681 tgtacaggtg ctgccggtgc ctgctgcatg acttgaaccg tgcctgcttc gtgttttttc 2044741 agttttaagg atacaccttc attttcatat acgaattcgt caattgtaga ctcgtcaatt 2044801 gctttaatca gctcgtggat ttctttgata tttaacattc aatcgcactc ctatgtatga 2044861 aatttctttt tttataggtt actactaaaa gtacatacta tgttcatctt acaggagcgg 2044921 acttttgaat tcaactctaa tatgacagca acgcaaaaag cccgcttgtt tagcgggctt 2044981 ttttccctca ttcttattta gagggttcaa atgtgacagc gacatctttc attgttttga 2045041 tttcttttgc cacaaggtct ataatggctg tcgccttcga tttagagtgt ttgtctgatt 2045101 tgactgtaat attgatttta tctccttcag cattaacaag cgcatcctcg taaccttgtg 2045161 ttttaatcag cgtttccagc tgtttttctg ttccttccac ttcactgaga gccgtcattt 2045221 tatcgtatgc ttcgcttttc tccttggctg ttgcatcatc gcttgacaca atggcattca 2045281 gctcttctct ttctttgctt ctggcatctt ctaaatcaag acggtacgtt gtaaacaaat 2045341 catcatcggc tgtttccgta acaacagttc ctttttcact ggcttcagcg gatgtttcct 2045401 tgtctgctga tgaatctttc gttccctttg ttccatcttc ttttcctttt tcagtttctg 2045461 taccgctttt ttccttcgtg tcttgcttgg caggcgcttt ttcagttgcg acctctccgc 2045521 tgtcagacgc gcttttttca ctttgcatct gcacggcgtt tttgctttcc ggcgacatga 2045581 tatagtagac gcttaacacc acgacaagac tgagcattgt taatagccaa acggtttgtt 2045641 ttttaagcat ttatgaatcc tcctttattt ttttaggggc aaccgcaacc cggtggcttg 2045701 gaacatccag gacccgtgtc accgcttcga taatggtttg ttttatttga acgttgtcca 2045761 ctccttgagc aacaacgagt acaccgcgta tatcaggttt tttcgtttgg acgacgacag 2045821 gtgtttcttt atcgccgttt ttgatcatga cgatttcttc ctccgatgat tggtctgtaa 2045881 cgcttctttt tccgccttct ttgtcagttt cttcagtggt tgtatttttg tttgatttgt 2045941 ttttttcgta tactttcagc gacgttgcat ctacattcac gacaaccgag acatcgtcca 2046001 caccaatgat tgtttcaaga atttctttca gttgattttc gtattctttt tcatagtcat 2046061 cgatcgagtc tttaggttta tcagattttg aggctttaaa cacttcggct gttttctctt 2046121 tgctgtctgc ggaatgttgt gatgatacgg ccgttatcgt tttggcgttt tcagttttct 2046181 caggtgaaga aaacagctgg ctgacaagca taaaggaaac tccgagaaca aaaacgaata 2046241 gaaagtaatg atatttggtc agcttcggct tttcgccgtc cttcgtttgt cccggaagaa 2046301 actgcttttt caatacattc cataatccgt ttttattcat tgccgacact ctccccgcct 2046361 tccatatgaa ccgtaatttt ctcacttccg atttcccaaa tgtccgcgag ctgcgtttgt 2046421 atctgtttgg cttctttttg ttcggctgct tcttttgtta cgtatgcatg atctgtatca 2046481 atgtggaccg gcgcgaccgt ttggaccgtt ttttcagaag acggggccat atacacgctg 2046541 attgttttaa tatcctcttc tgaatctacc ttttctcctg ccgtgagttt gatgcggcct 2046601 actttatatt catcatgact gaatctctcc tccgctttct tttttagttg gacagccatt 2046661 tcttctagaa tatatgcgcg ctgggaagct tgtatttcta ttttttttga attgatttga 2046721 ttttttatgt cggcagactc tgactgcccg ttttttgtga ggtattcaaa gatgacttcg 2046781 gggtctgtct tgaaaagttt aaaaatcggc gtaagcatga cgacaatcaa gagcaggctg 2046841 actaccattt ttgcgtactt ttgcatgctg gagctcggca gcagcatatc aatcacaatt 2046901 gcaaatagga taaacaacac gatggtggta agccattccg ttaaaaaact catttgcctg 2046961 cctccttcat ttcatcatca tcgtgaggtt tccggctgtg attatgacag taaggcttaa 2047021 aaaaaacatg agagacacaa tggcgagagc tgcaaaaata taaatgacgc ttttgctgat 2047081 gacgtcgagg caggtgatga cgggcccgcc tcctagcggc tgaagaatcg cggctgccag 2047141 cttataaata aaagcgaggg aaagcacttt gattgccgga aatgccgcaa tacagatcaa 2047201 aatagcgaca ccgagaatcc ctaccgtatt tttcagcagt aaagaggcgc tgattactgt 2047261 atctgttgcg tctgtaaaca ttcggccaag cacaggaata aaatttccgg ttataaattt 2047321 agccgtcctg agcgtaatgc cgtctgtcac tgcagctgac gctccctgaa cagagatgac 2047381 gccgagaaag atggtaagaa aaacagccag tgctccgatg gcgatatttc tgagcaggtt 2047441 agccagctgc gttactttgt attgttcagt catcgtgctg acaatgctca gaatcgctga 2047501 taaaaaaatc agcggcatga cgatattctg aatcaagaga ccgctcgtgt tcatcaggaa 2047561 gaggataaca ggatgaaaga aggcagcaga tacagctccg cctgaggaag ccaaaagcgc 2047621 caagaggagc ggaatgagcg ccaggataaa gctggtcatc gtctgaatcg cctcagttgc 2047681 atagttaatt gccacatgaa agctattaag cgcaaggata atcagcacca tgtacacaat 2047741 tgagtaagcg accttactga cggtgctttg ctgaaaagca ttttgcaaaa gctgcagaat 2047801 gacgcaaaaa atcgtgagca aaatcaatgt gcccagcagc tttccgttgg caagcacttc 2047861 atgaaacaaa taagaaaaga gagctttcag ccattcttgc ggtgagaatg atttatcgcc 2047921 attgataaac tccattaagc tgcctttttg gctttccggc agcagtccgc cgtattctgt 2047981 cataatgtca ttccaaaatt ccccgatctt atctgtttca agcgaggctg ctgtcctttc 2048041 cgctaattgc tcggctgttt cagcatggtc ttccgtttgt tctgcattac cagctgcttg 2048101 tacaatttct gcacggcctg ctatgatcag cacggccaaa agcaaaaccc attgaaagcg 2048161 cttcaatcta ccgcctcctt tcggttatga catagaaggt ataagtccga gaatcgtttc 2048221 gataatgacg gttaaaatag gcacagccat tacgagtatt aaaattttcc ccgccaattc 2048281 tattttcgag gcgatggctc cttgaccggc atcttttgtg agctgtgccc cgaattcagc 2048341 aatataggcg attccgataa tctttaaaat ggtttcaaca tagaccatgt tgacatttgc 2048401 attaatcgca attttttcta tcattcgaat aatgtcgtag atttggtcta ccaaataaag 2048461 aaaaatggca catccggcaa aaacgacgat taaaaacgca aaagtcggct tttgttcttt 2048521 tacaattaaa gaaaggaagg tggcgatcag ccctaaacct acaatttgaa caatgtcaat 2048581 ctgcaagccc ccctatcctt ggaataaaaa cacagctttt atctttttaa ataggtcatc 2048641 tacaatcgtg gcgaccataa ataaaatata gataaaacct aacagcgtca cccactgagc 2048701 atattctttc ttgcccatct gatccaatat cgtgtgtaaa aaagcgacca cgattcccac 2048761 tccggcgatt tgaaatatga cattcacgtc tactcccatt ttatttttgc tcccctcacg 2048821 tttacatcaa tagaagaatg agtaacaagc ccgctaaaaa gcccaaactt tttatcatct 2048881 tttcgttttt cgcttgcgcc tgctcagcat ccgcttctga ggcttccaaa tgtgtcagcg 2048941 ccagcttgat gtgcttttgc tgagagattc gatcatgaat cccaagcgtc tcgccaaact 2049001 gcttcagcac ttcgtattcg ctttttttca aagacagggt gtcccatacc ttctttaagc 2049061 tttgctccca cgccgttttc gcggaatcac ttcccttgtc cagctgatca ctgaatgcgg 2049121 aaaaaagagt tgaaacaggc tgtgcgagct gtttggcaat ctgctgtgaa gcagtatgaa 2049181 gcggtgtatg gccgtacatg atttcagcct cgagggattg aagcgccgca cgcagctggc 2049241 ggatttgccg cggccgttct gtataaatct tcgccatctc aaaacctgtc catgttgtcg 2049301 ctaccacaat gaatacagcg cccagcagct tcagcatgtt ttcacgcccg tcgtcctaga 2049361 cagcacattt ccgtctttgt cataaatttg gctcactgtg cccggccctt ttgctcttga 2049421 taattccaaa tagcggtcaa aggctctttc ttcccacaaa cgcttcaatg aaggccgctt 2049481 catcaggtcg gatatactcc agccatgcgc cgatacgatt actgaaacac cggcatgcag 2049541 cgcctccaga agtgcatctg tatcttccat acgcccgatt tcatcgacaa tcatcacctc 2049601 agggctcatg gatcgaatca tcatcatcag cccttcagct tttggacagg cgtctaacac 2049661 gtcaattctc tgaccaaatt gatgctgcgg aataccgcga agacatccgg caatctctga 2049721 ccgttcatcg acgatccctg tctttacggg cagcatgttt tttttgccgg tgcttgagag 2049781 cctcgcaagg tcccggagaa gtgttgtttt gccggtttgg ggcggtccga taatcagcgt 2049841 attcagccag ctgttttgat ataagtatgg aagcagcggc tccgcaatcc ccagcttttg 2049901 ccgggcaatt cgtatattaa aagatgcgat gtcacggagg cctttcacac ctccgttttc 2049961 cgtaatgact ctgcccgcca gtccgactct gtggccgcct ctgatcgtga catacccttt 2050021 cttcagctct tcttcaagtg tatacatact atagttgctg agccggctca ggatcagatg 2050081 ggcatcctcg gccgtgcccg cataggacaa ataaacaggt tgtcctcttc gaatcaattc 2050141 aacagggcgg ttgatccgaa ttctgacttc ttcgatttcc agccattgtt gttccggtat 2050201 ttcagaaagg gcgtttttca tggattcagg gagaacctca gcgatttcat tcaacagagc 2050261 ctcctccttt ctaccgattg gcttctttaa aatgtatgat gtgaggcaga ctttatgaca 2050321 agcctctctt tatttatgaa cacccgccaa aatcaagaca acacccgtaa aaatcagaat 2050381 cagctttgca tacgaaagct gcccggcaat ttggtagatt ccgacagtca ttgtaatgat 2050441 aaaaatcaac ggaccgacaa tagcgagaat gctgttaacc acaaccgcct tccggacatc 2050501 gttggtcaca agcatgacaa ttgctgccgt cagctcaatc atagaggata aaactcgtaa 2050561 tcccgccatt gttaaaacag tagaattgat atttccaagt aaaaatttca tagcactctc 2050621 ccaacctccc atttttttat atgatatgct ctagcttgct gaagtagtct tgtcattttc 2050681 gtataaaaga aagattctgt ttttgggcac aaaaaaagcc tgctcccatt tgggaacaga 2050741 cttctttttt tctttctatg ctcttgaaac gtaagaaccg tctgatgtat tgacaacaag 2050801 tgtgtcgcct tcattcacaa agaacggcac gtttacaaca agcccggttt cagttttcgc 2050861 aggttttgta ccgcctgacg ctgtatcacc tttaatacca ggttcagttt caacaacttt 2050921 cagctcaact gtgtttggaa gttcgatacc aagtgtttca tcctggtaca tcatgatatg 2050981 cacagacatg ttttctagca ggtattttaa ttcttcttcg atttgagttg cgctcagttc 2051041 aagctgctca taagaagaag tatccataaa tacgtgctga tctccgtttg catatagata 2051101 ttgcattgtt ttggtttcga tttgcgcttt cgctactttt tcaccagcgc ggaatgtttt 2051161 ttcctgaatc gcgccagtgc gaaggttgcg gagtttagag cggacaaatg ccgcaccttt 2051221 tccaggtttt acgtgctgga agtcaacgac gcgccaaatg ccgccatcta cttcaattgt 2051281 taatcctgta cggaaatcgt taactgaaat catgtttaat gtcctcctat attccaatca 2051341 caaaataata agttcttttg gggaatgggt gattgtccgg ttgccgtttt ctgtaatcac 2051401 gatgtcatct tcaatgcgga caccgcctgt ttctggtatg taaatgcccg gctccactgt 2051461 gaccaccata cccggttcaa ggatagctga agatctgacg gataatcccg gcgattcatg 2051521 aacttccatg ccgagcccgt gcccggttga atggccgaaa tagtcaccgt agccttttgc 2051581 agcaatatga tcccttgtga gggcgtcagc ctcttttcct gtcattcccg gcttaatatg 2051641 tgcgacgcca agcgcctgag catcaaatac aacctgatag atctccttca attgatcact 2051701 gggctgacct acagcgaccg tccgggtaat atcagaacaa tatcctttat aataagcgcc 2051761 aaaatcaagc gtaacaaggt ctccgctttc aatcagtttg tcactggcca caccgtgcgg 2051821 aaggcttgaa cgaaggcctg aggcgacaat catatcaaaa gaagagctgt ctgctccctg 2051881 gcttctcata taaaactcca gctcattggc aacagcgatt tcagaaatgc cgggtttcat 2051941 aaacgtcaag atatgtctga aggcatcatc tgcaatcttc gcagcttcct ctaatatctt 2052001 aatctcttca ctagacttaa tcaagcgcaa cttttccacg gattcagcca caggcactaa 2052061 ttcggcatca ctgataacgg cgctgtatga agcgtaagtg ccatatgtca tgctgttctg 2052121 ttcaaagccg agacgcttga tgccaaacga ttcaacagtg tcggcagtgg tctgaatcaa 2052181 gctgccgcca tgttcaatga tctcaaaacc ctttacctga accttcgcct gctcagtata 2052241 acgaaaatcc gtaataaacg ctgctttgtc acccgatata acagccaaac ccgccgaacc 2052301 tgtaaaccct gtcatatagc gtacattagt gttgcttgta atcagcatgc cgtcaattcc 2052361 cagctgtcca aacaggtttc ttaatttctc tagcttcatc ttgattctcc cccttgctgg 2052421 cttaataagt agcgaacagc aagcttgtag ccttcagctc caagaccgac aatctgccct 2052481 ttcgcaacag gagcgataac cgactgatgc ctgaattctt ccctggcgta taagtttgat 2052541 aaatgcacct ctaccacagg aagactgatg cttgaaacag catccctgat cgcatagctg 2052601 taatgactca gggcgccggg gttcagaaca atcccgctgt attgctcctc agcctcatgt 2052661 atcgcatcta tcaaatcacc ttcgtgatta gactggaaga aagtgagctg gatatgtaag 2052721 gcttcagcaa actgaaaaag atctgtttca atatcggtca gtgtctggcg gccgaatact 2052781 tcaggctcac gactcccaag ccggttaaca ttcggtccgt tcaaaatcaa aaaatgaggc 2052841 acacaatctc tccttttcgc gagggtttct catgtaaaaa atgttcactt ctcgtgaaca 2052901 ttttatcata ctggaaaagg attatacact attctctatg cattcccagc gcacgtgcaa 2052961 gcttttccga attcagctca ttgtattcaa atgaaataga atacccgaca aacagcccgt 2053021 aaagcaaata aatgcaaatg gtcgtaataa ttgtatctga tgtcagttcg gtcaccgtgc 2053081 gcacatctgg aaaaatcgga ttaaaaacaa aaaacacgag cagccaaagc accaagccgt 2053141 ataaaatacc cggccacatt gtttttaaac gtttcaatag aagaaaataa agaaatgctg 2053201 cgccaattga aattactcca atcaaaatga tgctgattac cgttcccagc ccatgttttt 2053261 tccactctcc gagtacaaac ggctgcaata tcatattcgg gctgatttcg gaaaaatgaa 2053321 acaaatatgc gatataagca acgaaactcc aaagtacgcc tccgcaaaaa cctgttgccg 2053381 ccaccctgcc ggccattgaa acaggcggct tttgcttctc attcaattct tcattttgtt 2053441 ctgtatcttt ttcgcttgtc atcatggcac ctccagttaa agtgtgccca aaaaatgaaa 2053501 tgtcaataaa aaagctcaca ctttttggca gctgcgagta aaatttgaaa ataacgggta 2053561 taatgcatgt agaaaaagca aggctatggc aattttttca gcctgtcaat ctagaggttt 2053621 agcgctgttt cctgtacaat agagtgaaag gaaatggtta gcaatcctaa agaaataggc 2053681 aggttgataa tatgtcaaaa cataaagttc cgcccgctta cggcgggcag gctgttgtgg 2053741 aaggcgttat gtttggcgga aagcatcatt acgttacagc catcagaaga acggatggaa 2053801 gcattgactt ttttaagctt ccacgcaaac acaacccgaa actgaacatc gtgaaaaaga 2053861 taccgttttt acgggggatc gcggccatta tcgaagcgag tgcaaacggc acaaagcatt 2053921 tgaatttttc aagcgaacgt tacgggctcg atccatctga agacgagaca cttgagcagg 2053981 aagaaaaaaa atcctctggg ctgtctatgt atctcagcct cgcagttata ggcgtcctat 2054041 catttttgtt cagtaaattc gtatttacat tggttccagt tttcttagcg gaactgacaa 2054101 ggccgatttt ttccttgaac acagcgcaaa tcgcgattga aagcctgttt aagttgattt 2054161 tgctgctcgg ttacatctat tttttgtcca tgacaccgct tattaaaaga gtgtttcaat 2054221 atcatggagc cgaacataaa gtcataaact gttatgaaca gaatttgcca attactgtgg 2054281 agaatgtcca aaaccaatct cggcttcatt accgctgcgg atcaagcttt attttattta 2054341 cgattattgt cggcatgttt gtttatttac tcgttccgac agatccgctt tggctgcgtg 2054401 ttatagatcg tgtcgcactg ataccggtcg tgcttggtat atcctttgaa gttctgcagc 2054461 tgacaaacaa agtgcgtgac attcccggtc tgaaattact tgggtacccg ggactttggc 2054521 ttcagctgtt aaccacaaag gaacctaagg atgaacaggt tgaagttgcc atcgaaagct 2054581 ttaacgaact tctcagactc gaagcattgt ctgagcaaaa tcagaagcct tctcacaacg 2054641 tcatctaaaa tccgttgccc tgctattact ttcggaggtg gacagttatg aatcatcgtg 2054701 tacaacctat tattgctgta ttaattgcgc tgggagcgtt cggtttcctc tatgtgctgg 2054761 taaccaatcc cggagaaatg gcaaaaatgg cggtaaccgt catcgtggca ggtatcatta 2054821 tttattttat tgtgaaatat gtaatgaatc gaaatgcggg cagcgaagga gcagccttca 2054881 aaaaagcggc gaaacaatca cggcgccgga tgaaagaaca aaaagcaaaa caccgcgccg 2054941 gacataaggg acgtgtcagc cacctgcgaa gcgttccgag cgccagcaag cctaagccga 2055001 tgattctcaa gaaaaaaagc cagactcagc tgactgttat agaagggaaa aaaaataaaa 2055061 agaaaaacag agcgcttttt taataggtcc actgctttaa aaacagctct gtccgtcttt 2055121 tacctagctc aatcagggct agtttttttt gttgtgttaa atgaaaatca gtggccatta 2055181 cgtcatcaac agggagaaaa atgatatttt gttcatagcg tgacgcaatg tgccttgcgt 2055241 catgagcatc cttcatcgtt tcaaacaggg cgccgaacag ttcaaaagcg ttgcggatat 2055301 tttttttcgg acgctctctt tcacgcggcg caagcgtgac accgatcaca gggcgctttc 2055361 tttcctttga aaacagccag attggaaaat tgcttaacac gcctccgtcg acaaccgtgg 2055421 cggtgcctgt gtccgttttt aattttatcg gttcaaagaa atacggaatg ctgcagctca 2055481 ttctgaccgc tctggcaacc gggaacatat ctggatttaa cccgtaacgg gccaaatcgt 2055541 ccggcaaaac aatcatggtg ccgtttgtca gatcagaagc aataaggcgc agagaccctt 2055601 tctgcaaatc gccgaaaacc cttatgcctt tcgctcttaa cagatcagca atccattttt 2055661 ctatcgtatc gcctttgtat aagccaagac gccagtagat ggacacccac tggagcatct 2055721 ttaaggggag aaatgagtac ctctgatcca gcaatttctc tccgtccact tcttcaatta 2055781 aagcgtggat ttccttactg gtgtaacctg acgcaatgaa agcggcaata atggcgccgg 2055841 cgcttgtacc cgcaactctt ttaaagcgga agcctttttc ctcaagcact tcataagcgc 2055901 ctgcgagcgc aatgcctttt actcctccgc cggaaaacac accgtcaata tacatctcat 2055961 tccctccccc tccatccgat cgtttattac cattttaaga aaacacgcga agaaatagac 2056021 caacgaatga cgggtggcgt cagcgtatca aaaaagacgg cctccttcga gaccgccttt 2056081 ttactgatta tgatgttctg ttttcttttg gattgatttc agatcttttt tacgggcatc 2056141 atcttcttca aaatattgaa caagatcccc gatgcgatca atactgttcc agcttaaatg 2056201 atgttcgatt ccttcgacat cgttatatat tttctcttca tcaacaccaa tgattcttaa 2056261 aaactgctca agcaattcat gtctgtatac cagccgtttg cctatttttt tccctttaga 2056321 cgttaacacg agaccgcgat atttttcata aattaaatat tcgtctttat ctagtttttg 2056381 aaccattttt gttacagagg agggatggac tgccaatgct tccgcgatat cggaaactcg 2056441 tgcatatcct ttttcttcaa tcagcatata aatctgttca atataatctt ccatacttgg 2056501 tgttgtcatc gaaaccctcc caaaaagcac cttaacttta taaaccatta caagtttaca 2056561 ctaatgaact tgaaaaaaca aggatgctcc gcgggtcaaa agccctgttt accgcttata 2056621 attccattca tctgaagcgt actttgtttc agccaagtga tgaacaaaat caagctcttc 2056681 ctgagaaagt tcatatggct ccaaatgaat gttaagacct gtttcaaatc cttctttaaa 2056741 ggctttacga gcctcatcca tcgtcacccg cttttcgatg agttcattaa tggcaaccgc 2056801 tttatttttg aaattgcgct gcatccgctc tcttactctt tcacttggat ataagaacag 2056861 atcgaacagc ttgtcctcat ctaaatcaag aagaatggag ccatgctgaa gaatcacacc 2056921 tttttgtctc gtttgcgcgc ttcccgccac cttgcgcccc tcaaccacta gttcatacca 2056981 cgaaggcgcg tcaaaacaaa cagatgaccg cggatttttt aagctttctt tttctttttc 2057041 agttctcggg atggcaaagt aagcgtccag accgagattt ctaaagcctt gaagtatgcc 2057101 ttctgaaata acccggtaag cctcagtaac agtcgccggc atctcggggt gctcttccga 2057161 aacaattacg ctgtatgtca gttcctgatc gtgcagcaca cctctcccgc cggtcgggcg 2057221 tctgacgaat ccgagattat atttatgtac tgcttcaaaa ttgatttcct ttttaatatt 2057281 ttgaaaatac cctacagaaa gtgtcgccgg attccagccg taaaaacgga taaccggggg 2057341 gattttcttt tcgctgtgcc aatataaaag cgcttcatca agcgccatat tgaatgcagg 2057401 acttgcattg cctgagtcta taaaccgcca agtttctttt tgcattttaa gaccttcctt 2057461 accgttttaa tagaatcagt ttatcaaact gtcgggaaaa tgaaaaatat tttagttcca 2057521 ttatagatga caatcacgct gtgctttact ataatagtat ttgtcgaaaa cggctctatg 2057581 accttgtttt atgaagcagg gttttgattt tatatgctaa aggagtagaa tcacattgtc 2057641 taatatgatc gttttgatta tttttgctgc atttatcatc tatatgattg cttcatatgt 2057701 ctatcagcag cgaattatga aaacacttac cgaagaagaa ttccgcgcgg gttaccgcaa 2057761 agcgcagctt attgatgttc gtgagccaaa tgagtttgag ggcggacata ttttaggcgc 2057821 ccgcaacatc ccgctttccc agctgaaaca gagaaaaaat gagatccgta cggacaagcc 2057881 tgtttacctg tactgccaaa acagtgtccg cagcggacgc gcggcacaaa ccctgcgcaa 2057941 aaacggctgc actgagattt acaacctaaa aggcggcttt aaaaaatggg gcggaaagat 2058001 taaagcgaag aaataaagca aacagctgtc tggtagacag ctgtttttat ttatctttct 2058061 tccgcctcgt atctgagcac tgggtgtctc gccgcttttg tttcatccat tctttttaca 2058121 atcgttgtat gcggggcctc ctgaacaagc tccggattct cctccgcttc ttttgcgatt 2058181 tgaatcatag catcaataaa cgcgtccagt gtttcctttg attcggtctc tgtcggctcg 2058241 atcatgatgc attcttcaac attaagcggg aaataaatcg tcggcggatg atagccgaaa 2058301 tcaaggagcc gttttgcaat atcaagcgta cgcactccca gctttttctg ccgcttccct 2058361 gataatacaa attcatgctt gcaatggcgg tcaaacggaa gatcgtaata aggcgcgagt 2058421 tttctcatca tataattggc gtttaacact gcgttctcag taacagcctt taatccgtca 2058481 ggccccatgg agcgaatata cgtatacgct ctcacattaa tgccaaagtt gccgtaatac 2058541 ggcttcacac ggccgatcgc atgagggcgg tcataatcaa acgtaaagcg cccttctttt 2058601 ttgactaaaa ctggctttgg caaataagga atcagatctt gttttacgcc gacagggcct 2058661 gagccggggc ctccgccgcc atgagggcct gtgaatgttt tatgcaggtt gaggtgcacc 2058721 acgtcaaatc ccatatcacc aggtctcgcc ttgcttaaaa cggcatttaa attagcgccg 2058781 tcataataca gtttcccccc cgcttggtgt acaatttccg ccatctctgt aatctgctcc 2058841 tcaaacaagc cgagcgtgtt cggattcgtc agcataagag ctgcagtttc ttcattcact 2058901 gctcttttta aatcctctaa atcaacaagc cctttttcat tcgatttcac cgtaacggtt 2058961 tcaaagcctg ctactgttgc tgatgcagga ttcgtcccat gcgcggaatc agggacaatg 2059021 accttcgtcc gcttgaaatc cccgcgagct tcatgatagg cacggatcat catcagcccc 2059081 gtccattcgc cgtgcgctcc ggcagcaggc tgaagcgtaa cctcatccat tcccgttatt 2059141 tcttcaaggt gtttgcttaa atcatataaa agctctaatg cgccttgcac cgtgtcttca 2059201 tcctgaagag gatgaatcgc agcaaaacca ggaatacgtg cgattttttc attgattttc 2059261 ggattatatt tcatcgtgca agaaccgaga ggataaaaac cggaatccac cccgtgattg 2059321 cgtttggaca gcgctgtata atggcgcatg atgtccagct ctgaaacctc cggcagcgct 2059381 gcgtcttcgt cacgaatata ggtgtctgac aagaggtccc ccaattcgat ttccggtaca 2059441 tcgagctccg gcagactata gccgattcgg ccttctcttg aaagttcaaa aataagtgcc 2059501 tggtcctgat tactcatggc gatcccccaa ttcctgaatg agtgcgtcaa tttcttcttt 2059561 tgttctcagc tctgttacag caatcagcat atggcagtcc agctctggat acgtcaaccc 2059621 aagatcatat ccgccaatca tgccttttgc cagcaaacgc ttgttcacag ctctcaccgg 2059681 ctcatccagt ttgatgacaa attcattaaa catcggcccg tcaaacataa cagtaaggcc 2059741 tgcttttttt gcttcttgct ttgcatagtt ggcttttaag agattttggc gggctatatc 2059801 ttttacgccg ttttttccga gagcagtcat ggccactgat gctgccagcg catttaaagc 2059861 ttggttcgag catatatttg atgttgcttt atcccggcgg atatgctgct ccctggcttg 2059921 cagggtaagc acaaagcctc tttttccgtt ttcgtcttcc gtttgtccga cgagacggcc 2059981 cggcaccttt ctcattaatt ttttagtaac ggcaaaaaag ccgcaatgcg ggccgccgta 2060041 tgctgaagga atgccgaaag gctgcgcatc accgacgacg atatcagact gaaacttgcc 2060101 cggcggagtg agaagaccta gcgccagcgg gttggctgaa acaataaaca tggatttccc 2060161 ttgatgagcg ataggctcaa tatcctttag cggctcgatc ctgccgaaaa aattcgggta 2060221 ctgaacgatc actgcggctg tgttctcgca aacggtttgg cgcaatgcat caagatccgt 2060281 aacgccatcc gcagcgggta cttcaacaac atcaatatac tgaccttttg cgtaagtttt 2060341 cagcacctct cgcgattcag gatgcacggt ttttgacaca acaatttttt tctttttcgt 2060401 gtggcctgaa gcaagcattg ctgcttctgc caaggctgtt ccgccgtcat acatcgagga 2060461 gttggcgata tccatgcctg tcagttcaca gatcatcgtt tggaattcaa aaatagcctg 2060521 gagctctcct tgtgaaatct ctggctgata aggcgtatat gcggtataaa actcagagcg 2060581 cgaaatgaca tgatccacaa tgacaggctg atagtggtca tatacacccg ctcctaagaa 2060641 agaagcgtat tgtacggtat cacgattttt agaggccagc tttgtcagtt ctcttgttaa 2060701 ttctgtctct gatttcgctt ttttgatttg atgctctttt ttatatttga cgttttccgg 2060761 tatatcagca aataaatcat cgatgctgct tacgccgata gtagcaagca tctcctgttt 2060821 atccttttct gttgcgggca aataacggtg cttcatgtgt tgtctcctct ctccaagaaa 2060881 aaatattagc gtttataaaa tggtgttttg acaacctttg ctttcactaa ttttttgcgt 2060941 atctctacat ctacaacagt cccgatctca ctcgtttccg aatcaattaa ggcaaggccg 2061001 acgttttttc ctaatgtcgg tgactgcgtg ccggttgtca cctttccgac agacttgcca 2061061 ttttggaaaa cctcatatcc gtgccgcggt atcccttttt caatcatttc gagaccgaca 2061121 agtttgcgct tcgctccgtt ttctttttgt tcactcaata ctgacttacc gaaaaagtca 2061181 gactcctttt tgtgctttac agcaaagcct atacctgctt caatcggtgt aatatcccgg 2061241 gtcagctcct gaccgtagag cgggagcttc gcttcaaacc ggagtgtatc acgtgcaccg 2061301 agaccgcatg gaatcaatcc gtatgcatcc cctgcatcga tgattttttt ccaaatatgc 2061361 atagcatcat cactgcggca gtaaatttca tacccgtctt ctcccgtata gccagtgcgt 2061421 gaaataagtg ctttgcggcc gctgatatcg gcttcatcaa taaacgcaaa cggctttaat 2061481 gcagacacat ccgcatctgt cagatttttt aagatcgctt ctgctttcgg tccctgtaca 2061541 gccaagagcg cgatttgatc tgactgattg tcaatctgca catcacctgc tgcatgttct 2061601 ttcatccaag ccaagtcttt atctatatta gaagcattaa tgacaagcag atagcggttc 2061661 tctccttttt gatagataag caaatcatcg acggttccgc catccgggta acacatcgct 2061721 gtatattgag cacggcctgg cgttaacgcg gaaacatcat ttgtcatcaa tctttgcaaa 2061781 aaagacagac tgtcgttccc tgacacttcg acttctccca tatgagatac atcaaacaaa 2061841 ccggctgcag ttcggacagc ctcgtgttct ttttttatag aagaaaattg aacaggaagc 2061901 tcccagcctc cgaaatcaat cgtttttcct ccatattcct tatacaggtc aaataacggc 2061961 gttcttttca gcatctaatt cctccccttt atcaacggcg cagctaaaaa acatacaaaa 2062021 aaggacagag aaacacctca tgtaaaatga aggttctctg tcctggcacc tgaaagttta 2062081 ctttgcatac gcaaagacgt cccctttggt ggtttgcgca tccgcacaaa cactctccag 2062141 agttgcgtcg agcaagagtt cttttgcctg agagattcac tccgcagttt gctccttcgg 2062201 cgcctgtatc ccgaggtttt cggtcaggtc tctccccttg ctgtcattcg ctcatatttt 2062261 catgctgtta tggacatact atagcaatat cttacatcaa atacatactc atatcctacc 2062321 atcatcacta tatgctgggc aacagcaatt tgggcagatt tttcttatat tattcatctt 2062381 aagaatcgaa gaataagaaa ggcggtttca aagcaatgaa tacagaaatg atctacgatg 2062441 caaaatggcc tgaagaattt gctgaaagac tgaaaaacga tggcccttgg gcaaactggg 2062501 aactgtacaa gctctctgca gaaatccaga aaacattagc aattccagag tttgaaggct 2062561 tacgggctcc tttatatctg ccttccttta cgccgctccc ccaccagctt gaagtggcgc 2062621 aaaaagtggt tgaaaaaatg aacgggaaag cgattttagc agatgaggtt ggtctcggaa 2062681 aaacggttga agctggactg attctaaaag aatatatgat tcgcgggtta gcaaaaaaaa 2062741 ttttgatcct tgtgcccgct tcccttgtgt cacagtgggt caaagagctt caggaaaaat 2062801 ttttgattcc ggctgttgaa caaaagaaaa gctatgtgtg ggagcaatgc gatattgtcg 2062861 tctcatcaat agacaccgcg aagcgctcgc cccatcgaga aatcgttctg tctatcccat 2062921 atgatcttgt cattattgat gaggcacaca aactgaaaaa tagcaaaacg aagaactatg 2062981 aatttgtccg gaatctcgta aaaaaatatt gcctgcttct taccgcgacg ccaatccaga 2063041 accgtatcga agagattttc aatttggtgt ccttattaaa acccggccat ttaggcagtc 2063101 agaatcactt tcaggaggag ttcgccaaga agaaatccag tttagaagcg catgaacatt 2063161 taaaagatct tgtgaataaa gtcatgatcc gtaacaggcg gcatgataca gggctgaatt 2063221 ggaaacagcg ccatgttgaa acagtgccga ttcaattttc tccatcagag caggcgcttt 2063281 atgatgaaat ttctcgtttg aaggacagta tcaataaacc agccagcatg ttctcgatta 2063341 tgaccttgca aagagaatgc tgttcgagca gagaagcggt atatatgacg ctgaaaaaga 2063401 tgcttgatca aaaagagaaa caagcacctg ccattgatga ggatacgatt tcagttttga 2063461 tagatcgcat caatcaagtg acacaaaact ctaaagcgct tcaagttgtt gacttgatca 2063521 aaaagatcga cgataaggtc atcattttta cagaataccg cgcaacccag atttatctgc 2063581 agtggtttct tcagcaaaac ggcatcagtt ctgtgccgtt tagaggcgga tttaaacgtg 2063641 gaaaaaaaga ctggatgaag gatcttttcc gcggaaaaat ccaagtcctt attgcaactg 2063701 aagcaggcgg tgagggaatt aacctgcaat tttgcaatca catgatcaac tatgacctgc 2063761 catggaaccc gatgcggctt gagcaaagaa tcggaagaat tcacagactc gggcaggagc 2063821 gtgacgtgca tatttataac atggcgacaa aacatacggt ggaagagcat attctaaagc 2063881 ttttatatga aaaaattcat ttgtttgaaa aagtggtcgg tgaacttgat gatattttaa 2063941 cgaaaattca agtgaacaat tttgaagagc accttcatga cattttgtat cactcagcaa 2064001 cagaagaaga aatgaaaata aaaatggata acttaacctc atttttgtct tataaaaaac 2064061 agctgcctgc tgaaaaaaga ggatcttagc ctgtaaggag gttttattag tgagacagca 2064121 agaggttcac gattttctgc tgcgtttttt tcaagcaaac agctgccaaa tcgtcgatca 2064181 aggcttaggc tatatgacag tgcagcttac agttgaaatg gacaaacaaa tcatgaaccg 2064241 ccctttctac tggcattggc gcgagaagac aggcggtgat ccgaatccaa tgaaaatcac 2064301 ttttattaca gataaagaaa atgcgccaaa agacctagat ggtgaattta tatattttgg 2064361 ggccccgcgt ctttttcaaa tattcaaagc tgttaaacaa aatgggagat ttaccagaat 2064421 gtatgagaaa attgaatcag ccggagctaa agtcccactt cagccttggc ttggtataaa 2064481 tgtcacgatt tcataccagt ccgacatgaa aaaggataag ttattgtcac taggtcttca 2064541 cctagtctct ggaacgataa ttgaagattt tcaaagcaag ctgacccagt tttcactgac 2064601 gtctcaaata tgtgactatt gcttcaccat ttcacctatg atcaaaccag aaagcggact 2064661 taagcgtatg gaaaactata tttccaaatc cgctatgcag gagccgtccg actgggcgga 2064721 acaggcggtt aacaggtgga agaatgatat gacattgctt gataagtttt acgagcatat 2064781 agaagaaaaa ccagaagaat accatctaga aaaacaggcg ctgaaaacct tgtatcaacc 2064841 aaagatatca gttgaaattg aaaatggcgg attgttttat ctgcaaaata atatttcaag 2064901 ctaacttttt taccattcga catcattctc gttttttttg agaaaatacg attataataa 2064961 aggtatattg gaaaaaaatt ctggtgattt aatggcaaat gacttccaga gactaatgaa 2065021 gcatacaata agtcatggcc ggactggctg aaatacataa acaagtattt taggaggaga 2065081 aactgcatga agaatgcaaa acaagagcac tttgaattgg atcaagaatg ggttgaatta 2065141 atggtggaag ccaaagaggc aaatatcagc ccggaagaaa tacgaaaata tttactttta 2065201 aacaaaaagt ctgctcatcc tggtccggca gccagaagtc ataccgtaaa tcctttctga 2065261 atgtgctata atatcacaag gaaggtgatg acattgattg gccagcgtat taaacaatac 2065321 cgtaaagaaa aaggctactc actatcagaa ctagctgaaa aagctggggt agcgaagtct 2065381 tatttaagct caatagaacg aaatctacaa acgaacccct ccattcaatt tctcgaaaaa 2065441 gtctccgctg ttctggacgt ctcggttcat actttgctcg atgagaaaca tgaaaccgaa 2065501 tacgatggtc aattagatag tgaatgggag aaattggttc gcgatgcgat gacatccggg 2065561 gtatcgaaaa aacaatttcg tgaattttta gattatcaaa aatggagaaa atcccaaaaa 2065621 gaggagtagt gcctgagcag aggcactaac tcctcttttg tcaataacca tcgagacggc 2065681 ccagtatatg aatactgggc cgtctctttt ttttgctgtt attaattttt atcctcgcta 2065741 tgcgcgagct cgtcttgctc agtattgctc attttttcaa ttttttagaa atttttggga 2065801 ttgttatgtg agaatttaaa tgcatatccc attattattt ggtaataata aacaaagaaa 2065861 gggtgacagc atgatgatca aacaatgtgt gatttgtcta tctcttctcg tctttggcac 2065921 cacagccgct cacgcagaag aaacaccgct tgtaaccgcc cgccacatgt ccaaatggga 2065981 agagattgct gtaaaagaag caaaaaaaag gtacccgctc gcacaggtac tgttcaaaca 2066041 aaaagtatgg gaccgtaaaa gaaaagatga agcagtgaag caataccatt taactctgag 2066101 ggaagggtca aaagaattcg gcgtttttgt gacgatttca tttgatcctt atagccaaaa 2066161 ggtcaataaa attgccatat tagaagaata tcaataaggt cctccatttt ttgaaggacc 2066221 ttattcgttt atttgcggtt attttttccg tttcagccaa agtcggaagc catagggtaa 2066281 aataccgaac cactgctggg aaacaggcgt ttttgtttct ttccgcacct cttttcgttc 2066341 ttttcgctca tctctcggag tatctatata tttgacaaat tgctgcgtca tatatttaac 2066401 ataatcattc gttttcacgt gatcacctca tcattcaatt attatgagtg ttgtctcaca 2066461 tgactttttt tatacccttt acactgtttt attctgtcca tctcagcagt tttttctgtt 2066521 tttggtcaaa cacgatctgt gcagttcttt ctgttcccga atccgttgac actcttaagt 2066581 tgatttcttt ttgttctttt atcgatgtat catgaatgta ataagaaacc cgtccatata 2066641 gaaattgctg cgtaccctcc tggcctttcc gttcctctag aacatgccga atcgaaagaa 2066701 gcaccccatt ttgaagcaaa ttctctccta tgtataactc ttttgtttcc ttctcaaaca 2066761 tgcagcgtga aatatattga gcagcaacaa agttcacgat taacagcaca agcgctgaca 2066821 caaaaagaac agctggataa ataaaccctc ttgtacgata cattcacccc cctcctaaat 2066881 acgaatagac tggaaaagca gtttgataca ctttttggtc ttcactctca attttcagca 2066941 aaacaacacc attttcaata tcagctttca tggcagtaat atgatctaaa atcggaacat 2067001 gccctttgcc atccactctt tttcttatca ttgaatgata aatgtcaaaa cggatgtctt 2067061 gtccggaaag attggtgcag attaacacgc tcccatgctc ggctgtctta actgcctgtg 2067121 attccttgca ttcattcatc atctgttcta tcgaaatcat ccattcctgc tgtgtgaaac 2067181 cgtcatgttc ctgctgtcga gacaaaaaca gatggataat cgcagctaac gatcctgata 2067241 tgagcaaaaa gactgagagc gaaaataata cgttaagaag cgtgtagcca ttctgtctgc 2067301 aaaatgctga ggcaaaatga tttttcttta taagctgcgg ctttgataca tacgttttga 2067361 tattcgccct cctcctccca cttcattgca tagatatgat tgttctttgt aatcgttttt 2067421 gacgcggctc cttcaccact catgacatat ttgctaatgc tctcattcat catctgatag 2067481 ccaatttctc gtgattccgc cattttttca tcagccatca gcttgtccca caaggggacg 2067541 actgtcagca gcacaaacag ccacaggctt agcgcagaca ttgtttctat tgtagaaaaa 2067601 cctttatttt ctctccacat tgactctccc gctccctaga taaactgtta tgtcataaac 2067661 ggcatggcct tttactcgta tttttccgcc tgcattcggg tgccctttct cattaaattc 2067721 caaacggtct tttaatgtca gcagttctat agaaagtccc gttgcatacg gacgttcaat 2067781 aaccgtatca ccaatgacta attgatattc ttttttatga aagagaattt ttgttctttg 2067841 ttgacgggaa atagcagtct gctgtgtgag cataatatca tttttcagct gacttgctgc 2067901 ctgtcggaca gctgtattgt cataagcagg aggaagtgta gtgaagacgg ccaccaggag 2067961 gatagaggca aggcttaaca caagcaaact ttctaaaagg gtaaacccct tctcctcgtt 2068021 taatttaatg ttcaacctta acttctccgc cggtgatgat aatgcgctta ccatttggac 2068081 agacagcatc ctttttcaca tagccctctg actgtaaatc ggcaaggctc ggagtttgtc 2068141 cttcatgatc aagctcaaat gcagtcattt gtgccttaac catgttttgt aagccttcac 2068201 agcccttttt ttgaatggtt tgattatgtt tcgtgacgtt cggtatcgta attaaaagca 2068261 aaatcgaaat aataaagagc acgattaaca tttcaacaag tgtaaatcct ttctcattca 2068321 tcagcctctt cctttcacat ttgattcatc atctgataca taggcacaag catagataaa 2068381 tacacaagta agatcatcgc tgcaacaaat ccataaatca ttggctgaag gatgcctgtc 2068441 catttttgcg ctttgtgttc cagccgctgt aatatgaatt ggctgtatgt gaaaagctcc 2068501 cgatccaatc ggccgctcag ctggccgtga gatatgactt ttgataaatc agtttcataa 2068561 aaaaggcttc cacaaatagc ggattcaatt gactcaccgg cttttagccg ttcaatcaat 2068621 tgttcagcct cgcagcggta gaaagggaga aacgtttgat gtttaaatgc attaaggctg 2068681 tcataaattg agaggcctga ttttaaaagg ctgcttagct gcaaagaaaa aaagtagctg 2068741 ttaaacagct ttacaagctt tccaaccaaa ggaatcctga tacaaatcag catttgccgg 2068801 gcaggtgatt ttttcttaaa cacaagccaa taataaatcc cgatacctgc tgtaaaaaga 2068861 acaagcaaaa tgatcacaag atcaatatgc tgaaaaaaag caaaaagcat atcggttgaa 2068921 cgtgaggttt ccatattcat cgattgatag ataccggaaa actgaggaat gatgatggac 2068981 tgtaacatat aaaacatgac agcgaccgta aagatgagga aaagcggata gcgcagcact 2069041 cttttcagct ggtctgcctg tgcaattttt cgttccagca gctctccgct ctggatcatt 2069101 gaagcaggca gttcaccatg tgtttcagca aaataacaaa tacctacggc ttccttatga 2069161 aatgacaaac tctttagtac ttgataaaac ggagcccctt ccctcaaaca agtgaccgaa 2069221 tcagtcaagt cagccgcctg cctcttattc atctgaagtt ccatcaggcg taatccatcc 2069281 agaagtgtat atccgcccgc agtcatttca ccgagcctct ttaataacct ggcttgatcc 2069341 tttaacaacc agacttttct aatctttttc atgataaacc caccggtcat agttgtttgt 2069401 cgttaaatag ccgagcgcaa ttccttttct gataatttga cgaagcgttt gatattggta 2069461 atttgcatga tttccttttg cctcctggat acattgctga agatttttcc cgtatagaag 2069521 ctcataaacg ctagctctcc tagtatttcg tgactgtcgg caatacactg atgaacatcc 2069581 gttttcacaa aacgggcaag ccaaatcaac caagcgctga gccgctattg caatgacagt 2069641 ctgttcgatt tcattcatat tgataccgaa ttcaagcagt ctgtaaattg cgccctttgc 2069701 gtctctcgta tgaaggctcg ttagtaccag atgtcccgtc atcgctgccc gcaccgcaat 2069761 ttcagctgtt tccgcgtctc tgatctcacc taaaataatc atatcggggt catggcgcaa 2069821 aattgctttc agacctgcgg aataagttac accggctttt tcattcacct gaacctgaag 2069881 aacatcttcg tcccttgttt caacagggtc ctctaatgtg acaatatttc gattaaagtg 2069941 tttttttgca tattgaacga gagagtataa tgtggtagtc ttccctgaac cagtcggccc 2070001 ggtaaaaatg agcatgccat gggaatgttt taaaaacgag agtaatgtgg ctcctgtctt 2070061 cggaaatagc gacaatttat caatcgaagg gatattgtat tggggcatca ctctgatcac 2070121 gaggctttct tcattaattg tgggcagcgt tgacattctt aaatgaacat ttccctcttt 2070181 caactttaac gtaagcgaac cgttttgcgg ctttcgcctt tcacctatat ccattgctga 2070241 aagaaattta aaatgtgaaa tcagtcttac gcactcttct tttttcatgt cccttttttt 2070301 cagcaaggca tgatcgaccc gaaaatgaat gatagcgtcc cgctccctcg gcacaatgtg 2070361 aatatcagaa gcctttgtta gatatgcctc ttcaatcaag tttttgctta ccttttctat 2070421 tgaatccaat ttgattccct ctcctttcaa cgcatattgt agaaaaagaa gaaaaggtaa 2070481 tcaaacaggg aaaacgtgat tttgtgagat gttatatgct gaaaaaccaa ttctttctgg 2070541 caagaaaaaa gactttcaac tgaatgtacc cctgtcatta taattttccc tataaataaa 2070601 aaagcagaca tggtcaccat gcctgctaga ttccattttc attatgctgt tttcgcttat 2070661 tgaccagtat ctttctcaac ggaaagatcg cctaatgcaa caataccggt catttggtca 2070721 ttttcaagaa tcgataaact gcggatttaa tgctctgtca taagcccctt gacatcgtat 2070781 ccggtcaccc tgatatgtct ggtgaaaaag cggggcacgc tgcacaaaat atgaaacatc 2070841 ctatagagtc cgcctttttc gaggtttctt tttcttcttc cgctcctgca gcatatctcc 2070901 cgtccagcct ttttttctca aatagagata gatcagaact gtagatgtga caatcaataa 2070961 gagggaaaag agatatccgt atttccaatt cagttccggc atcactgaaa agttcatccc 2071021 ccataaggca cccagagctg taatcggagt aaaaagcgtc gtgaaaatgg tcagcgcttt 2071081 tacaatttca ttccccctat gtgaggtaat gacttcctct gaatgcagca gattgttaag 2071141 ctccccttca aattcgctga tgtatgtaaa tcccctgtca atcttcagtt gtgtccgctg 2071201 ataatccttt ttcccttcat tttgaggtaa aaaggtttct ttcaacgcca tttcaatttt 2071261 tttagcgctt aatatcaaat ttttccaaat catcagttca tggcgcagga gatggacgcg 2071321 gtttaaaatg cttttgctat tgtcgtcttt aatttgccat ctgagctttc tcagcttgac 2071381 ttcaaattca tcaacaccga ttaaatacgc attcattagt tcgccgagaa gaattaaaaa 2071441 cccctctatc gcattgtccg ctctttccat ttgccgaaca acttctttgc ctttaatctc 2071501 tctcaaaatt gaaaagtcaa agttgattgt aaaaaaatat tgtctggtga tataaaagtg 2071561 aaaaacagta tggtcttttt cttcaccaag cccctgatca taaacaatcg acccaaatac 2071621 tgcttcattt tccgtttcag ttgtatctac tcgcaaaaaa ttaacgtgat ggttattttc 2071681 aaaccacttt tcacactgag gccagtgaga aaaatggatt agatctcttg ccttacttct 2071741 ttcttgaggc cccatttggt accaaaacca atcctttccc gtatgtgcct tcatgtcaag 2071801 ctcctccaaa cttttgttct ttattcttta attgcccaat aaccgcgtca ctaaaccagt 2071861 ctgccgcttc aacacatgtt ttatgagcat tttcaggtgg tatggaatgt agaaagacat 2071921 cggaaaaggg aggtgcatgc cttccttgga gaaggcagtt gttttggaat ttatcaattt 2071981 actagcagtc gctattctca ttttgttaac aggatttttc gttgccgtag aattttcaat 2072041 cgtaaaagtg cggcgatcca aaattgatca gcttgtcgca aaaggaaaga aaggtgctaa 2072101 agcggcaaag catgtcatca ctcaccttga tgaatattta tcagcctgtc agctgggcat 2072161 cacagtcgca gctttaggac tgggatggct tggggaaccg actgtgcaaa ctctgcttcg 2072221 accgcttttt cataaagcag gcttaaatga atcgcttacc cacctgcttt cactcgtcat 2072281 cgcattttta gtggttacgt atttaaatgt cgttattggg gagctggcgc caaagagttt 2072341 cgccattcaa aaagcagaaa gcattacctt gttgttcgct aaaccgctta tttggtttta 2072401 taagatcatg tttccattca tttggctgtt gaaccactct gcccgattga ttacaggagt 2072461 gtttgggctg aagccggcat cagagcatga gctggcttat acagaggaag aacttcgggt 2072521 cctattggct gaaagctata aaagcggcga gatcagaaaa agtgaattaa agtacatgaa 2072581 taatatcttc acctttgata aacgaatggc aaaggaaatt atggtgccgc gaaatgaaat 2072641 ggttagtttg tcactagatg aagactccat ttcaaatctt caggaaacag tcaagcaaac 2072701 aaaatataca cggtacccgg ttgtaagaga ggataaagat aacgtcattg gcgtgattaa 2072761 tatgaaagaa gtgctgtttt ccatgctgac gaaagatttt tcaatcaaga agcatcaaat 2072821 tgaacctttc gtacagcccg ttatccatgt aattgagacg attcctattt ataaactatt 2072881 gctgaaaatg caaaaggaac gcactcatat ggcgatcctc atagatgaat atggcgggac 2072941 gtccggtttg gtcactgtcg aggatattat cgaagaaatt gtaggagaaa tccgtgatga 2073001 atttgatgcg gatgaagtgc ctcatatccg cgaacttgga aaggatcatt acttgttaaa 2073061 tgcaaaatta ttaatcagcg atgttaacag cctgcttgga accgatttat cagaggctga 2073121 agtagacacc ttgggcggct ggtttttgac acaaaacata gacgctgagc ctgaaagtgc 2073181 catagaatat gatggctact cttttaaggt aaaagacatc aacagccatc acattttatt 2073241 tatagaagtt aaaaaagctg aatagcccgt gaaaggctgt tcagctgcta tctttcaaga 2073301 taaacatggc aaaggcatca acactctttt attttaaacc ctttattggc cagggcttta 2073361 gcaagacttt gctctgtttt cacattcgaa aaatccagac ccagcttcac gacagtttgg 2073421 gcaatttccg gcctgattcc tgaaataata gtctcaatgc cgagcaattt ggtgctgtca 2073481 atcactttaa aaatttgata ggctaccatg gtatcaacga taggaacgcc cgaaatatct 2073541 aaaaataaat acgagagctt taacgctgag cactgctcca gcacagactc caaaatcgtc 2073601 ctcgctctgt gcgtatcaat ttcaccgaca agcggaagaa tcccaattcc atcagtaatc 2073661 ggcataatcg gcgcactcaa ttcattaatc atttcttttt gcgcgtttaa ttgtatcatg 2073721 gtcacctggt gatattcttc cgtaaacact tcgatgatct catcaatgtt ttgattcaag 2073781 atccggctcc actcataaaa ttcctgaatg ctgatgtctt gagaagaagc ttcgctgaat 2073841 ttatgaatcc attcaaacat gatgtgcctg aaagtgttaa actggccgac actttgtgta 2073901 accgtcactt catgaacggc acggtctctg gcgcattgaa gagaccaccg gttgagctca 2073961 tcctctacgt cttcttttct aagggatttt gctacgatgg tcaccaataa ttcatgctgg 2074021 tcttttaact tttgttctag tttttgctga tctttcgctg aatacagcca gctgccgttt 2074081 gacgtacaaa cttccagcca ttgttgcgta atatcttttt tgtgctctgt taagtgctga 2074141 tcaagagcta tcatcttaat gagttacctc ctgtttttga aaaatgtacg ctatatatgt 2074201 ataacgcgtc tgcctttaca catactatgt ttagattcaa tgggctatag ccaagcggta 2074261 aggcaatgga ctttgactcc gtgatcgttg gttcgaatcc agctagccca gtttctgaac 2074321 aggtgaaaaa ccgaagataa gctgattcgt ataaatcagc ggatcttcgg tttttcatca 2074381 tgcagattga tgaaccgttt tcttcttcga taacttcaac agttctcccg ggttataacc 2074441 aatcaccagc tttttgttgt ctactagaat cgggcgtcgc aaaagcttcg gcttctcgat 2074501 taaaagttcc agcacctcat ttaccgtcat ttcttcaatg tttaaattta aatttttgaa 2074561 agtctggctt cttgtcgcca aaatttcatc aattccttct gtcgttaacg ataaaatgta 2074621 ctttaattct tctcttgtcg gggtttctct gaataagtgc cgttcgttaa attcaatttg 2074681 atgtgcttta agccaatgtt ttgtttttcg gcatgacgtg cagcttggat atgagtaaaa 2074741 agttaattgt tgttccattc gttttttcct cctcagttaa ccatctcttt gtagaataac 2074801 tacccggatc atttttcatt taaaccattt acagaacttt tttcggatta ttttttaaaa 2074861 aacattcata caatagaaaa cacaatcaaa gggacaaatt ccatttgtat attaataatg 2074921 aaaatgttta catttctagg tgtgatctat tataataaca gtcagaggga ctctcgggag 2074981 gggataaaaa tgaatcgcat gttccgggtg ttaggatttt ggacgggaat ttttgcagtc 2075041 atgttttatt taggtgatat gaaagatgct tcccttttat tttttggaca gacgatctta 2075101 tttgtgtttc tatcgtattt gaacttaacc gaacgcatgt atatttatat ttttggcgct 2075161 tatttaacaa ttttcttcgc cggctttaca tattactcaa tttttattat ggtgcccggc 2075221 ggcggaggcc attaaatgca gaaagagaca aaccttatcg gtttgtctct ttttttacaa 2075281 tgaaaaccca tttaaaaacg gattttgatc ctgctcagtc agtacgtctg tttcaggtcc 2075341 atggccgctt aacaccagcg tgtgttccgg aagcgtaagc agtttttcat gaatggacgt 2075401 cagcagcgtc tcttgattgc cgcctattaa atccgtacgt cctataccgc cttggaacaa 2075461 gacatctccg gaaatgacca agtctgcatc tttcacgtag taagacacac tgcctggtga 2075521 atgtcccggc gtaaataatg tttccaaatg aaacggcccg atattcaact caccgtcgcc 2075581 ttcaattaga tgatctgcag gcttagctgt gacttctatc cctcgcagca tgccggagcc 2075641 gtttaaagaa gcgtccgcaa gccaattttt ttcattttga tgcaggtaaa cagggatatc 2075701 ccatttttct ctcacttcat caagcgcccc aatatggtca aaatgggcat gtgtaagcaa 2075761 aatggctaaa ggcgtcagcc ctttttcttt tatgtattga ttgattttat gtccctcgcc 2075821 gcccggatca aaaatcagac attgatcatc actgatgaga aaatatgcgt tcgcttgaat 2075881 cggccctact ggcattcgtc tccatttcac tattatcacc tctttctttt ttatgctctt 2075941 attatgaggg tttttgaaaa aagattcaaa caatcgcaat gaaaacgcta tcgacaaacc 2076001 tataaaaaac aggtagaata aaactggaaa gaattgcagg tttttcaatg taaagggggc 2076061 tgtgttatgt tacttgtcgt gattttcggc cttgtcgctc ttttcgcttt atggggagtc 2076121 ttgcgttctg ttagaaataa aaatatactc gggtttttat tagccggtgc caccttattt 2076181 gtctttggat ggtttaccgt gatgaccgta ataaacagcg ggtatccaac cgcacattaa 2076241 aacctgtatc cgatcggata caggtttatt tttatggctg taaatgttta ttgacacttt 2076301 ctattttgct ctcaagcgtc gtttttttgt cacgcctgtc atcgatacgg atattcgttg 2076361 ccactctgtg caatcctttt tgaaatggcg cttcgtgaat tgcctgaata actgcaaaaa 2076421 ggtcactgag ttctccctcg atcagcgtat tcatcggtgt cagctgatat ttgattttcc 2076481 cttctgcttg atatccttct aatatctttt gcacatcggc tacgtaagca ctgacactgg 2076541 gtgtttccgt accgattggg ataatggtta catctgcgat agccatcgtt attccatctc 2076601 cttttgatca atgatgagtt gcttcgtttc atgtgatttc aataaaataa tttgctcaaa 2076661 atgaaagccg tataacgcat atttcccgtt cggagatatt tgaatcggct ccatttcccg 2076721 cagagacaca agatcttttg tctctcccga tgctacattg attgctgcga gcttatatgc 2076781 atcgccgctt tgtttgaatg tataaaacag gcctcctgct tcatcatagt catactccat 2076841 tggagccaaa cttgtatatt tcgcttggag cggccatttc gctgtaacag gtgatgttga 2076901 ttgcggcgtt ttaaactgat acgtcccttt tcctccggaa gctgatttga cagtaaaact 2076961 catttgatgg aaagaatcga agaatagaac gttatcctca agcttctgtt ccgtcttaga 2077021 agctgtatcg aacgtatata aaggccctgt tttatcgtct ctaccctctt ttacataatc 2077081 aaatgtattt ttggatgtcc aatgaatgaa cggaacctgt actgggctta agaaagattc 2077141 gtctttttta gcattcacct gatatgtatg gaaatcccag ttttcattga attccgtcac 2077201 catcatttga taaggatcat actgattcca agcagcttca agctcatacg tttcgtaatc 2077261 tttttcgtaa agcgtctctc cttctgcatt aagcaaaacc actgccgtct tttggctatg 2077321 tgtgatttgc agcagaatca tctgctccct cgcattgatt tgaacatcaa cgatttgacc 2077381 atccgtttga tagagctttt tcgctttgcc tgtaaagatg cggtacgcaa aaagctctgt 2077441 tttcgtcgga ttagacgcag tatataatat tgtgctgtta ttcagccagc cttccgcccc 2077501 atccgctttt tccgcggaaa gcggtatgat gtcttttttc tcatcttttg ccgccgatgc 2077561 ctgtttttgc tgctgatgag atggttcgca tgccgataaa ctaaacagca ataccgccag 2077621 cagaataaaa caaactgatc tcatcagcat tcccctccga tcatctttat tctctcatat 2077681 ttgcttcggc agaaaaaaga aaaagtttca gttactcatg aaaaaataac gccctccaca 2077741 agataccgct tgtggcgtta tatatgtgtg aaaactgctg aaacggcaaa ggattttggc 2077801 cttttccaag ttccaccgta tacccttcct taaaataatg gtgaataaac caatcacgaa 2077861 atccagcata gctgtctata tcccttactc ccttataaat gttcccgctt aactcctcaa 2077921 actcctttat gacggcagca gattcctcag gctcaaggcc tttatagccc caataaattt 2077981 cttctccttg agtatgaaga gccagcagtc tgtcaggcgg attctccgtg atcagccggt 2078041 acatcgcaat agattccggc tccgtaagcg gagagattcc cggaaaatcg cggtagctgg 2078101 gtgctgtcgg ttttcggtat ttttcaattt cccataatga tggaaattgt ttatttaaat 2078161 caaccccgtt tatattcgcc ttccattcat taaaatttgg acgatgttca tttagccttt 2078221 cgagttcatc tcttctggct cccatgactt ctgatccgtt taaaacaaga tcaacgccat 2078281 ccggattgac aagaggaacg agggataagg atgtgctgtt aaacagcttt atgggagaaa 2078341 agccaaagaa aggcgaattg cagcataatg acatacagta ttccttaaac cattttagca 2078401 ggacagacgt tgtaatccac tcattcgcat gaaatgacgc gttcatatgg acctttttta 2078461 cggcatgctc cccaccagcc ttcagctccc agataggcct gccgagtaca gaacggccaa 2078521 tttcccggca tgagacaaac ggaaaaacat caataatctt ctttatttcc ttttcaacag 2078581 ctgaatcatc atagattttc tcttgctcaa tccagctatc tgaaagtttc agctgccgag 2078641 gctgtaaaaa gcgctttatg tcctgaatgg tttgaagctc tttgccgcta tgctcctcta 2078701 tcacataacc agggcaatac aattgatgtt tttgtgcgga gcgatttgca cttttaagca 2078761 attcctcgtc tatcttcagt tctttcgcca cattggccaa attgttcttg atctcaggtt 2078821 tcaccgtaat aaacgccatc atcatccccc ttttttgtta ctatatgaca gcgtatttaa 2078881 aaaaagaaag cctcccgctc acttcgatgc gggagacatt gtgattatga tgcctgatca 2078941 agcatttgtt tttctttccg ctttgacgaa ttgtccagcc ttttctggtc ataaaatcgc 2079001 aacaaatccc cataaatgat ttcatcagaa agtgatagct cctgttttgc tttatcagca 2079061 aatgcttcac attgttttgt ctcttctaac ggttttcccg tctctttgtc ataacacgca 2079121 ccgtctgtat aaacaacctg atctgtgata aagctcccgt cccggagcac cgtgaagtcc 2079181 agtttttcgt ctgaaagcag atcgttgccg aattgaattt gatctttcgt atcaatccct 2079241 aaaagattca tcagcgtcgg cctgatatca atctgcccgc ctactgtttc aatggtttgc 2079301 ggctttttat cagtaatacc cggaatatga atgaccagcg gcactttttg gagctgtacc 2079361 tcttcaaatg gggttatttc ttttcctaaa aactgcccca tcgcttcatt atggttttct 2079421 gatataccat aatggtcacc atataataca ataacagagt tgtcgtataa cccgtcttcc 2079481 ttcagctttt cgataaaccg tttcagcgcc tcatcctgat aacgcactgt cggaaaatat 2079541 ttatttagcg tctggctgtt tgaatcatat tcatcaatca attgatcctc ttcatcaaga 2079601 tcaaacggga agtggttcgt cagtgtaatc agcctcgagt aaaacggctg aggcagattt 2079661 ttcatcagct ctgaggactg ctcaaaaaat tctttatcct taagtcccca gccgactgaa 2079721 ttttcgtcag ttacatcata cgagttaata tcaaaaaacg aatcatatcc aaatgagtcg 2079781 tacattaaat cacgattcca aaagctctta ttattagcgt ggagcaccgc tgaatagtat 2079841 ccgctgtttt tcaaaatttc aggagcggcc atatattgat tgcccgcatt cgtaaaaaat 2079901 acggcacctc gtccaagcgg atacagtgaa ttgtccacga taaattcaga atccgaggtt 2079961 ttcccctggc ctgtttggtg gtaaacatta ttaaagttgt agctctgttt tataaagtca 2080021 ttcagaaaag gcgtgatttc ttctccattc aatttttcat taatcacgaa gctttgcgtc 2080081 gactctaagg atacgagaat gacgttcctt ccttttgcag cgccgaataa gcgtttgttg 2080141 gcatccttcg cattagcggt tacgtagttt tcaatctccg tcaggctgtt gctgtctgcc 2080201 aacgctctct gtgcggattg ctttgactga agaacgccat cgtaaatatg aaaattaaac 2080261 aggctaatgt ttttaacaag catttctctg tcaaatgagc gtgtcaatag ctgaggtctt 2080321 tccgcctcag acaagcccag gttgaagaaa taaacagaag caacgaacaa aaaataagcc 2080381 gcccgttcat ttttcgttga gggaatgtcc gattgaaaag ctttttgccg gatgtgaagc 2080441 catattaaaa ccgcaatatc tacagctaat aggaggtctg tcggctcaag aagtgttccg 2080501 atgctgcttc cgagatcacc catattgctc gtttgaaaaa gaacagggat tgttaagaaa 2080561 tcattgtaaa aacggtaaaa aaccatattt gccagcaata caaacgtgac aagacagctc 2080621 atcgcgataa tgtagcgatt tctgtttttg ccttttaaaa acaggctgag gccaaaaata 2080681 agcaacaaaa aactcaatgg gttgataaac agaataaatt cctgtgttag attgtcgatt 2080741 ttaatatgaa aactggtttt gtaaacagca tacgttttca gccacatcaa taaaatggca 2080801 atcagcataa atgaaatctt cgaaaaaaac gtttttcgca tttcaacctc ctatgcagca 2080861 cgctcaaaaa aatcagtcta ttcccaacat tctcattaac acatcaaatt aaatcttaac 2080921 ctgagcacaa caaaaaatca atttcattta cacaatttta acaattttga tgtttcagcc 2080981 attcattttt agcgatccaa gcgcctccga taacgccggc atcatttcca agtgctgcga 2081041 ttgaaatatc agcagcttgg gctgcccgcg gaaacgcgca tttgcggaat gttttctcga 2081101 cttttgatct cagcagttct ccggctctcg atacgccgcc gccaagaacg attttggatg 2081161 gattaagcga gcttgccaaa tttccgagca ccaaaccaag atgcttggct acataatcaa 2081221 ccacctcaag ggcaatttca tcattttcac ccgccgcttc aaacacatct cgcgctgaca 2081281 attgttcggt tgcttttaaa cgtgtcgtct ttttagcatt tgctattttt tcttttgcaa 2081341 ttcttacaat tccggttgct gacgcaattg tttcgataca gcccgttttg ccgcagttgc 2081401 agggcgctcc gccttcaggg atgctgcaaa tatggccgat ttctccgccg gcgccattta 2081461 taccatgtac aatttcacca tttgcaatga tgccgccgcc aactcctgtg ccaagcgtca 2081521 cgagaatgac gtcttttgcg ccatcacccg ctcccttcca catttccccg agcgcagcaa 2081581 tattcgcgtc attttctata acagctggga tgccggtttc tgtctccaga tggtttttca 2081641 aagcataatt tttccaccct agatttactg tttcataaac cactcctgcc gccatatcta 2081701 cagggcctgg tgcacccatt ccgatgtatt tgatgatgtg cttcggtttt tgcagctcat 2081761 ccagcttgct gtcgattgtt tttgcaattg tgacagtaat cgtgtcgccg gttttatctg 2081821 tcggaacttc ccacttatgc tgaatttcgc catattgatt aataaaagcg agtttaatcg 2081881 tcgttcctcc caggtcaatg cccgcaaacc atatctcgtc catttttatc accttagcct 2081941 ttataaaaat ctcttccgtt ttttgtttgt tccaattctt ttcgaaggac agctgccgct 2082001 ctggcccact gctccttttc aatcatgtgg ttcatgtata attcctttaa ttcatccagc 2082061 ataaactcaa tttcaagctc tctgtctcca aaataaacaa tgtggccaaa cgtttttaac 2082121 agctgctgca catcataaaa tgtattcatt ttcctcacca tttcttgaac ttaactatca 2082181 taagcgtatt cataaggaag cggtcagtca agaagaaaac gctgacaaaa aagccagctt 2082241 cctttccata ttccacctct atgattcttt attgttttca atttgccgct gcagctcctt 2082301 gtagcgctgc tccttcggct tcagtttcac agccgtctgg atggcctttt ctgcttgtgc 2082361 aagctcattt ttttccgcat acaataacgc taaattgtaa taggaagcat ggtctttagg 2082421 ttcttttttc actgctcgtt ccaaaaggga aaccgcctga tcatattcgc cgatttgaat 2082481 atcagaaaca gcaagaattt tcaaaagatc ggcagaggca tctttttgcg ctgcttctcc 2082541 gttcagcaat tctgttactt cttcatactt tccttcctga tacagctcgc ttgcctgctg 2082601 aatcagcgct gactcctggt gtgaaggcga atgcaatccg taatataaaa atccaacagc 2082661 caaagcaatc agcaaaaccg ctgacaacaa tctttttcca aaggctccgg ctttaggcaa 2082721 ccccagtgct gctgcagcga aaaagccgcc aatcaagccg ccgatatgtc ctgaattatc 2082781 aatattcgaa accgcaaaac caaagcccag attgatgata ataatgacaa taatattggt 2082841 tcctatagtt cttaaaaaca tttttcgatt agacaaagca acatacagta atgcacctaa 2082901 gcatccgaat atggctcctg atgcccctgc cgaaggatac gggctgaaca caaaactcgc 2082961 aatcgaaccc gtaatgccag cagccagata aatcagcaaa aatctccccg atccatacat 2083021 ccgctcaacc gctgtaccaa ccgaccataa agccagcgta ttaaaagcta aatgcgctat 2083081 gccgatgtga agcacgatcg gtgtcagaag ccgccaccat tctccttgtg caatcaggct 2083141 gttttctttt gctccaaaag ccaccagtgt ctccgtatta gtgctgcctc cgtttatttc 2083201 gagcaagaaa aacatcagga tctgaagcgc aataaataaa tatgtaaaag tcggttttcc 2083261 gttttgaaaa accgccgctt cagtttttct ctgttcttct tgtttcagca ctagcgaaag 2083321 gaagcgttct cgcgccattt gcgcgttttc aaacgaagcg tgttcctctg aacaatcttc 2083381 tgtacgaaat gatggaaaaa ccgcttgaag atcatctcga agcatcgttc ctctaacgat 2083441 cgccggctca actgacacag ttcccttctc aaaagttttt tttgcaatct cttcccagtc 2083501 atcaactggg gcttccgttg aaaaaaacac gttcagcagc ttcatccttc gtctgcccaa 2083561 ttgatgtctg actcgttcta ctcgttcggc ctgctcttcg atgtctctaa ccatttcttg 2083621 acggaaatca agatcgtgct tataaagacg aactagatca tgagaggact tgtccggcgc 2083681 ttccagccat atttcatctg actcaccggc ttgtatgacg ccatacccgc tattcaccag 2083741 gtgcgccgca attttccaat atgtatactc cagcaaaaac atgtttaccg ctccaatagt 2083801 tttttttcat tataacagct ggcgctccga aacgcctact gaaagcaaaa aatcccgttt 2083861 ttcacgggat tttagaaagc ttgctgtata aacttattgc ggataaatgg aattcttaaa 2083921 aacaaatgga taaaagaccg cctgattcct ggctggctga gtacagtatt cataagacgg 2083981 tagcgatttt gataaaacat gacggcagaa accgcgaaaa tggcatatat caaaagtttt 2084041 ttcatgatat ccctcctgcc aatagggttt gttattctac cttatttatt ctcgaataag 2084101 ggacaggaaa gttatgaaaa acaagaaata atccgatcct ctgttatcag cttatgtacc 2084161 gggatgtcat gcggcagacg gggtacgtgc gcaaacaact ggcactccaa aagcaaagag 2084221 actgtcttcc cttcatattc acttaaatag cgatcataat agccgcctcc aaagccgacc 2084281 ctaaacccgt taacatcaaa acaaacaccc ggaacgatca tcaagtcaat ttgtgatggg 2084341 tttacttctt ttgttttttc aattaccggc tcgagcagtc cggcgtacac ggtttcgagc 2084401 tgatcatcag tctgatatgt gcgaaattgc attttcttcg tgtccggatg gcattttggg 2084461 atgcaaactt gtttcccttc ttcccaagcc tgctcaatga caggacgcgt cggtatctct 2084521 aatcctctgg aaatagtgac ggcaatggtg ccggcatttt gccactccgg cagagaaaac 2084581 aagtacttat acatacgttc cgttttttga agaatatctt catttgataa agcagacagt 2084641 gcctccagcg tcttttttct taattgtgat ttcatctctc atccccctcg gaatagaaaa 2084701 aaagccagaa cctttttcaa agctctggct tttttcttac acctcaaaca gcaaagctgt 2084761 tattttgttt cacggtgtaa cgtagatttt ttatcacgtg ggcaatattt tttaaattca 2084821 acgcggtctg gattgttgcg tttgttcttt ttagaaatat agttacgctc accacattca 2084881 gtgcaagcca aagtaatatt aacgcgcatt attttccctc caaactaaaa tcatttactt 2084941 attcagactt atatataata ccactataat ggacggaatg ctaggctgtt tttcaatgaa 2085001 ttgctgaatt attgaagata cgctcataaa gctgcaaata tgatgacata atgagtcggg 2085061 ggtggtggag cttgaacact tgttgtctgc cagcttcttt tatccggcgg gctttttccc 2085121 ggtcttttaa aaaactgtcc agcagatcag cagcttcctg tacgagcgta aaatcagcga 2085181 tgattgccgt tttgtcatga accgcataat cacaaaaacc acctgactga gaaacgacag 2085241 tcagcacacc ttgttccatg ctttcttgcg cggcaagccc aaacggttca taagaactag 2085301 ggaaaacagc catttcacag tgagacagta acgttctgat atctttccta tttagaaacg 2085361 gcagaaacat gacgcgatcc ttcaggttat atgccgcagc caatttctca tagcaggaca 2085421 gagacggccc ctccccagcc agcactagat agaggtcagg ctgacgctgc ttcaagatgg 2085481 caaacacctt taacagctgc gataatcctt tttccggaac aaaccttcca tatgaaaaga 2085541 ggaatcttct attcatgctt ctcgggattt tccccttctc ttcctccata gatgcagggc 2085601 ttgggataac ggttattttc ttatgtgccg ccttatcaag agaccgcttc ataaatgtgc 2085661 ttaatacgat caatgcatca gcggattcta taaggagccg ttcggtcatg agcctgtatg 2085721 ggtgtggggc ttctcggcac accttcttcc tttcgctttc aagaccgtgg attgtcgcag 2085781 caagcggaag gccaagccgt tgtttcaaat actgggcggc aggggcagtt gtgtcatcat 2085841 gggcatgaat cagatcaaag cgtttattgt gtgataacac atggcgaacc attgtaaagt 2085901 tagcatcagc tatgtaatct tcaaacttcg catacgaaaa cagctgcccg ctcggagtaa 2085961 aaaccgtaat gttgatatga gggtttaaat aggaaatgag gcggtttaaa tggacaccga 2086021 gcccgctttt cggctcatcg ggatgttcgg gtgaaagcat gagaatgttc accgttcttt 2086081 ttcccctctc ccataacagg tgtatgcaga aaattgcgcc tcccacctgg tgtgcgcttc 2086141 ttcaatctga aaactgttta tatgacgaat cccattttca tcaagataga tgtcgtctgt 2086201 accggcaagc ttgagagaga cattcattga attcacaatt ctgtattcag cccgatatac 2086261 agcatcacca gccgcctgtc taatcgtcca ttctccttta tcatacgttg tgcgttttgt 2086321 cctgacagct tcaatgtctt ttcttttgat gacaatgcgc aattctttta tcatatcctg 2086381 cgttttttcg aaaaggaccg cttcagccag ccgcattgtt tcttctgaga tttcccagct 2086441 tacggtcaag gtgtgagcgt tttgaatgat tatgtcgaat gtgtccctaa aaaaggaaag 2086501 cttatgtcgt atattatagg gaaatgggtg tttatccatg gactcctaac attctccttt 2086561 ccaatcgttc acttcgtgtt cctattaaac cattacatga agaagaagcg aagaaagatt 2086621 tctcgacaaa atctcgtttt tttcgcgaat tcctttagaa actattggtt ttatggtata 2086681 aaaaagaagg ataaaaaaag aatagaaggt gatgaaacgt ggaaattgct attattgcgt 2086741 tgtttatcgt cagtatagcg ctaattgcat tctcatattc tcaaagagac ccgatgaaag 2086801 atgtagaaca ggagctcgaa acactgcagc tttctgcgat gcaggaaatt tacaagctca 2086861 aaaagaaaat gacagtgctt gaggaagaat tactggaaac aaaccttgtc attcgcaaat 2086921 caaagcagaa cgacatcaat caaaaaatcg ctaaacaaat actttctaaa tataataacg 2086981 gtatgtcagc tgaagcgatt gctaaagctg aacatgtatc agtggaagac gtgaatacga 2087041 ttatcaaaga taatgagaag gtgctcgtat gacaaaacgg ggcattcagg catttgctgg 2087101 cggcatcatt ttagcgacag ccgttcttgc agctgttttt tatctgactg acgaagacca 2087161 ggccgctgct gtaaaagata ataaaacagt aaccgaacaa gacgtgaaca attatcttga 2087221 ttctaaaaaa ttggtttctg tcaaccgtga tgaatatcaa aaacttctcg attcaaaaga 2087281 gaaatcctta aacaatgaca gcggctcaga cacgaaatca gacaaagtca aaacctacaa 2087341 gctcaccatt aaagacggca tgagcacggc ggatgtatct gctattcttg aaaaagaggg 2087401 cattatctct tcggctcaag actttaatga ctatgtcatt gatgccggct atcacaaaga 2087461 aattcgtgcc ggcgagttta aagtaaaatc agacatgagt ttcaaaaaga tcgtaaaaac 2087521 gttaacacga taaaaaaaca ggctgactca gcctgttttt ttcatccaaa ctttcctgaa 2087581 atgtaatcga gcgttctttg gtccttcggg ttagagaaca ttttattcgt attgtcgcat 2087641 tcaacaagct cgcccatgta gaaaaaggcg gtttgatcag aaacccttgc tgcctgctgc 2087701 atgttatgcg tgacaatgac aattgtatat ttatctttca gctctagaat gagttcttca 2087761 atttttctcg ttgagattgg atctagtgca gatgtcggtt catccatcag caaaatatca 2087821 ggattggtcg caagtgctct ggcgatgcaa agacgctgct gctggccccc tgacagcgaa 2087881 agagcggacg tatgcaatcg atccttcacc tcatcccata acgccacgtc ttttaatgac 2087941 ttttccacaa tttcctgaag cttcttctta tttttggtgc cgtggactct cggtccgtaa 2088001 gccacattat caaaaataga ttgcggaaac ggattccctt tttggaatac catgccgata 2088061 ttttttcgca aatccacgat gtccacttta tcctttaaaa tgttgctgcc attatagttc 2088121 agctcacctg caagctttac attcggcgtc atttgaatca ttaaattcaa tgtcttgata 2088181 aaggtcgatt tcccgcatcc ggatggtccg ataatcgccg taacctcatt ttcataaatg 2088241 ctcaaattga tattttttaa agcatgatgc tgcccatacc ataagttcat tccattgact 2088301 tgatatactt cctgtttcat tacagcttcg gtagcaatac tcattgccgc cctcctatcc 2088361 gaatttcccg ttaatataat cctctgtctt ttgctttttc ggactcgtga aaatctgttc 2088421 ggtctgtccg tattctacaa gctcgccgtt taaaaagaat gccgtccggt cagaaacccg 2088481 cagagcctgc tgcatattgt gcgtgacaat aataattgag tattctcttt tcaatcctgt 2088541 aattaattcc tctatttttg catttgaaat cggatcaagc gctgaagctg gttcatcaag 2088601 cagaagaaca gccggcttca tcgcaagcgt tctcgcgatg cataaacgct gctgctggcc 2088661 gccggataac gagagtgcgg atgaatgtaa acgatccttc acctcatccc agagcgctgc 2088721 ttttgttaaa ctttcttcca caatttcatc taaaacagct ttattccgct ctccggcata 2088781 tttcaatgca tgtgtgatat tcgcatagat cgatttcgga aatggatttg gtttttggaa 2088841 aaccattccg atttctcttc tcaagctgac aacgttaata ttgccgccca atatatttaa 2088901 tccctcataa aggatttcac cttccgctct tgcagatgga attaaatcgt tcattcggtt 2088961 aatatttctc aaaaaagtag attttccgca tcccgacggc ccaattaaag cagtcaccgc 2089021 atttttttca atatccatgt ttacatgatg aacggcttgt ttatttccgt aataaatgga 2089081 cagatctttg acctcaagca cgtggttctg cttcggaaca ataacagctc gctcaggttt 2089141 ttcttttacc atttgttcag acatgttttt cgcctctttc cgttctaatt tgccgtaagc 2089201 tttttgtaga tcatcgtgcc aagccatctc gccgcgagat taaacacaag aacagaaatc 2089261 accagcacgg cagaaccacc gttggcaatc gcttcagcat ccggaatcat tccttgtgta 2089321 ttgacgttcc aaatgtggac cgcaagtgtt tcagcgggcc tgaaaatatt aagcggtgat 2089381 gtttccgaaa acgggttcca ctccgtaaaa ttaagacgcg gtgttgtcag gcctgccgta 2089441 aataataatg cggccgcttc cccgaacacc cttcctgacg ctaaaattgc tcctgtgatg 2089501 atagaaggaa tcgcacttgg aattaaaact gtttttacgg tatgccagcg tgatacacct 2089561 aaagcgagag aggcttcctt cagatcttta gggactgaac ggatcgcgtc ttctgtcaca 2089621 cgcaccatga caggaaggtt aaaaacagtt aacgcaagcg ctccgcctat gatcgtataa 2089681 ccccagcctg ttaagttgac aaacatcaat aatccaaaca tcccaatgac aatagacgga 2089741 agagatgaaa gcacctctat acatgttcta atgaagtcag ttactttgtt attaggcgcg 2089801 tattcagcca tgaagactcc gccgcccaca ccgagcggga ttgtaatcag cattgtaata 2089861 aacaaaatat aaaaggagtt aaacagctga tctcgtatgc ctcctccagc tgcaatggcg 2089921 ctcgactttg ttgtaataaa ttgaaaactg agctgagaaa caccgtttat aataatatag 2089981 gaaaacaaac ctactaaaat ggcagcgata atggctgcac acaaaccaaa cattccggtc 2090041 gccagtttat ctgttatttt gcggttcatt acactttcct cctagatgac aagtagcgaa 2090101 taagcaggat gaacaagaat gacatcacca gaagcacaag ccccattgac cacagcgtat 2090161 tgttttcaac acttccgtat gtggtgtggc ccatattcag cgtgatgatc gttgtcagcg 2090221 ttcccgcagt gtcaaacggg ctttccggca atactcttgt atttccaatg accatctgaa 2090281 cagccaaagc ttcaccgaac gcccgagcca tgcctaacac aacagctgtc atcaatgttg 2090341 gaaaagctgc aggcacaagt acttttctga tcgtctgcca tcttgtggca ccaagcgcgt 2090401 aagaaccctc tcgtaaactc ttcggaagag aagccattgc atcagcagaa atcgatgtga 2090461 tcgtcggcag aatcatgacg gaaaggacaa tcgttcccgc caataaactg tgccctgttc 2090521 cgctcgattt gaactgggcg ataaacggca ccaatactgt aagacctatg aatccataaa 2090581 caacagatgg aataccgact aaaagctcaa tcaccggctg cagcactttc tttccccaat 2090641 tcggggcaat ctctgtcata aaaatcgcac ctgcaatgcc aagcggcgca gcgattagag 2090701 cagaaagaat cgttactgca aatgagccaa aaataaatgg cagcactccg tatttcggat 2090761 cactatctgt aggattccaa tttaagctcg ttaagaattc aattgggctt acaccattta 2090821 caagaaaaga ttgcagcccc ttaacgccga ggaaaatggt aatcgcaaca gatgccgcaa 2090881 tcataatcag tgcacaagct gtgactatca ttcttccccg aacttcatcc aattgccgat 2090941 tttgcctaga gctgattaag cgctcgctca cagacatatt ttctctattg tttatcattg 2091001 ttttacactc ctatgaatgt gttaagagga gaaacggttg tccccgcact cctcttttta 2091061 ttaagatcag ctttgcttcc cgttggcatc acgtgtcact ttcatatcag taaccggaat 2091121 gtagccttgg tcagtaacaa tgcttttttg aatgtcttca ctctttagat aatcaagaaa 2091181 ttctttagct aaacctgtcg cttcaccttt tgtataagaa tgttgataag cccagatcgg 2091241 atactcgcca gttgctacat ttttcgcttc aggtttaaca ccgtcaatag atagagcagt 2091301 tactttgtca tctgttaaat atgagaatgc aagatatcca atcgctcccg gagtatcagc 2091361 aatgatcttt ttcaccgtgt tggaggaatc ttcagtaatg ccttctgcag gctccgctcc 2091421 gtcaagcgca tatttcacaa atgtagcacg tgtgccggaa gaatcagggc ggtttacaag 2091481 tgtaatcttt tggtctttgc cgccgagctc tttccagttt ttgattttgc cagtgaagat 2091541 ttttttcaat tcatcttttg aaatatcctt tacaccagca tcagggttta cagctgctgc 2091601 cataccaact acagcgactt gatgatcgac aagcgctttt gcatcgatgc cttctttttc 2091661 ttcagcaaaa acgtctgaat tcccgatctg aacagctcct tcagagactt gagaaagccc 2091721 tgttccagaa ccgccagctt gtacctgtat atcagcatca gggttttctt ccataaattt 2091781 ttccgcggct gcaagtacta gtggctgcat tgccgatgaa ccagaaatgg ttaaagaacc 2091841 tgatgccttt tcttctcctt ttgcagaatc gctattcgat tttttacttt ctcctgcatt 2091901 tccgcatgca gctgcaatca tcataaaagc agccatcaga agcataagca ccaatttgtt 2091961 ttttttcatt tcctgaattc cccctgcgta taatgtgtaa tttgtcctac acgtatagag 2092021 taaaggttct atgtaaaaag ggtttgaacc gaatgttaag gttttgtaaa tcagtgcgtt 2092081 tttttgtata aaaaaaacgc ccacatcatg tgagcgtttt tttttagtta tcagaagacg 2092141 ttgtgttttc tgcattttct tcaattttgt ctttattctt ttgctgagta ccttctttgt 2092201 cctgcttcga tttcagctca aaatatttat ccattacttc cctgccgatt tcgtttgtaa 2092261 ttgagtatct ttgattgtaa tcaatgtaag tccaaggaac tacgacagaa atagcaatct 2092321 caggattgtc agctggtgca taagccacaa gcgtcgtatt ataagtgtct gttcctgttt 2092381 ttgatttatc cggtccgtcg taaaatgatt gggctgttcc tgtttttgca gctggtttat 2092441 acgatgctga agccagttga cctgcagctg tccctttagt ggcaacccgt ctaaaaccgg 2092501 cttggacctc ttcaatatag ctactcttca tatcgacttt attcaatact tcaggctgaa 2092561 cagaatcaac gactgcgccg atcccttttt tcgcatttga atctctgact tcctttacaa 2092621 gctgaggctt catgcggtag ccaccatttg ctatggtgga gacatattga gccaattcca 2092681 gcggtgtata agtatcatac tgtccaatgg cgaaatcaag caagaaacca gataatctgc 2092741 ttgtaccttt atatcccgtc atttcatttg gtagatcaat tcctgttttt actcctaatc 2092801 caaattgact gaaataattt ctgaaggtat caaatgcaga agtatccaaa ggcaatgctt 2092861 ggtgaggttt atattcacct ttaccaactg caattgctgt tttaaacata aaaacgtttg 2092921 atgacttctc taatgcagtt tgaataccaa ccggccctaa gttttgccaa gattttttcc 2092981 ctcttttatc ctggccgata tacaatggtt catccttaaa tacagtattc aaattaatcg 2093041 ctccagtttg aagaccggtc aaaacggttg caccttttac agctgatccc atagcgtagg 2093101 atgaagtcat ggctcctaat gcataatcat caaacttata ggctccattt tctcgtttaa 2093161 tctgcttccc tgccattgtc agcacttcgc cgtttctagg gtccatcatg acaacgaatg 2093221 cacgatccaa caattcggta ctaggtcttg ctttagcagc tttaagtttt ttctcaataa 2093281 ttttttccac tgatttttgc aaatcaatat caattgttag tacaagatct ttcccggctt 2093341 tgccttcaga taccgttttt gttcccgtga cattgccttt tgaatctgtg atattttcga 2093401 cttttgcttt ttggccctgc agaaggcttt catattggta ttccagatag ctttttccga 2093461 ccctgtcatt tcggctgtag ccaagcgaca gataatggtc gagcaagttg gacggcaatc 2093521 cttcattaga gctggaaaca cttccgagca ctgagcgaag aaggttttta taaggatatt 2093581 cacgttccca atcggacgtg acatcaacac ctggcagttc gtctaaatgt tcacttacca 2093641 ctgccatttc cttcgctgat acatcttcgt ttttgatata ttgaggggtc aatgcatagc 2093701 ccgaatccat ctgtcttttg atagcaagga tctgcatatc tttatccgtc aattcattca 2093761 gctgcttatc agtaatccgt tttagctgaa gctggtataa atcgtcatcg gatatttttt 2093821 tgtcttcaac ctgctgtctt tctttagagc taatgagctt tttcgcttct ttcggtctag 2093881 tcaaaatcca ataatctttt ttatcccgtt ctgttacttt ttttgtatcg actttgatca 2093941 tgtcagacag cttttttgcg atctttaagc gctgttcttg cgtggtcgat ttagatctcg 2094001 tgtatgtgat tgcatttaaa gccttatttg tcacaatggc attaaagttt cgatcataaa 2094061 ttttcccgcg tggtaccgct gagctgactt cactttgttc ctgcttattc gcttggtttt 2094121 tgtaatcatc accttgcacg atctgcttga tgcccagttc cacaataatc caggtaaata 2094181 taacaaaggc agctaaaaat aaaatattca gccggatcgg aagcgacttc tttttctctt 2094241 tatgattttg cttttttggt ttatttctcc tcataacatc accttttcta tttacagaaa 2094301 gaaaagacac tcaagtaaga gtgccagttt tcattttaaa ggttttttcg acttttttct 2094361 acagataacc cctttttggc aaaaaaatta tctctcgcct tttaaaaggg tcggttctgt 2094421 tacccgtttt tggccgtctt cttccatggt ttcattttcc ccttctttct ccttaaaacg 2094481 aatatccttg acaaagtaat aaatcaaagg atgtcctata cccaatatcg caagtgacaa 2094541 aggaattccc acatcctctt tcagaagggc cacaatcagg agaaagcaca aaatggaaac 2094601 aattctgccg gcgttcaaga acatttctct aagcacgata tattcaattc ttgcttttct 2094661 ggcatgcctc gcgcgcccta tcacatcata tgtaagtgat acatatggca caagcaacag 2094721 aggatagccg atggcaataa aaacgccgta cgttaataat gtcgaaaagc tcatatggaa 2094781 cagaatcaaa aacagcgcgc catacaaaat aagtccgccc agcaaaatcg atttttttct 2094841 cgcctttttc ttaatcagcc tggatgcaaa gtagtaggca aagaaggaaa cagctgaatt 2094901 gacaagaccg aatgtaccga gagcaagctc gctgtttgtc tcaataaata caaacacact 2094961 gattaaaaag acaaaaatcc cttctctcaa accctgaaaa aaatgcgcat tcgtgattct 2095021 ccgccaattc atattgctat ggcgctctcc aaatactttg ctcagcataa aacggccctt 2095081 tgattctctc cgttttaaga aaaagctcat cacgacagcc agggcaaata aactgaggga 2095141 gagactgaaa atcactgtat aacccgtatt attttcaagc cttgagatca cgaatccggc 2095201 tacaatcggg ccgatcattc ctgcagagga agacagaatg cccataaacc cgttgaaaaa 2095261 gtctcgtgta tccggctctg ttatttcaaa ggtcagcacg ttaaacgcta gccaataaaa 2095321 gccatagcca actccgagca ccgcgccgat tagcacgagg cggctggccg ccgtttctcc 2095381 ggctaaaagc acacttaaat aaaaggcagc taaaaaaatg acgccgaacc ttaaaatgaa 2095441 taccctgtct atttttttgg ctaaccgtcc agccaaataa aaggttatcg gctgcattgt 2095501 cacaatggat aaattatata tcgccaaatc aataaatttc cctgactgct tccaaagata 2095561 cacattaaca aatgtattgg acagtgcaat tcccagcgag taaagcccgc caatggtcag 2095621 cagaaagagt aagcctttgt ttacgtctac atcgcctatc acttttttta gtttgctcat 2095681 tactgactcc cctttactat cccttagtct gtctcactca aaccgagata tgtaaaaaga 2095741 agacataaaa aaacaaggtc ccataatgag gaccttgttt gtgccattat tttgcttcgc 2095801 tgtatagacg agccacttcg tcccagttta caacattcca gaaagctgaa atgtaatcag 2095861 gacggcggtt ttgatagtta aggtagtaag catgctccca aacgtcaaga cctaagatag 2095921 gcgttttgcc ttctgaaagc ggagaatctt ggtttggcgt gcttgtgatt tcaagtttac 2095981 cgttgttcac aacaagccat gcccagccag aaccgaagcg tccagctgct gctgctgcga 2096041 attgctcttt gaatttgtca aagcttccaa atacactgtt aatctcttca gcaagcgcgc 2096101 cagtcggttc gcctccgccg tttggagata aaagtgtcca gaataatttg tggttcgcgt 2096161 gtccgccgcc gttgttgcgg actgcagtgc ggatgttttc aggaacagaa tcaagatctg 2096221 caacaagctc ttcaactgat ttgttggcaa gagcagtgtt tccttcaacc gctttgttta 2096281 aatttgtcac gtatgtgttg tggtgtttcg tatggtgaat agtcatagtt tccttgtcga 2096341 tatgcggttc taaagcatcg tacgcataag gtaattctgg aagttcgtaa gccatgataa 2096401 ttcctcctta gtatatatgt actgaaatgc cgcttcacag cgagcctttc ttcattcaat 2096461 gtaacaaaag aatgctttgt aatcaatgaa aaagctcacg atttggctca tttcagcgga 2096521 catatttcac tttaaccgat aatctgcccc attaaacctg ccgccagcat ttcttatagg 2096581 accgtccata aaaagtaacc gatcatcaaa agctgtatga tgccctttgc aataacccct 2096641 gttaaaaaac caatgagtga gccgaggcca attttaaacg ctgactttaa gtccttctga 2096701 tggacgataa gttctgcgca aacagccccg ataaacggcc ccaatatgat ccctgcaacc 2096761 ggaatgacaa aaggcccgat taataaaccg atcgtgcttc cccatatggc agctttgctt 2096821 cctccgaacc tttttactcc aagcagattc gacacgtaat ctgctgcgaa taatactgcg 2096881 gcaaaaactg cctcaacaag ccagaacata taagaatacg gactgaatga aaataaaaat 2096941 ccgtacaata caaatccggc aacaataaat actacgctag gaataacagg atacaccagc 2097001 ccgataaagg caatgataaa aaccgctgca atcaacagcc aatacaacat atccatagct 2097061 tccatcctcc cattttactc tgtcttcttc atgtcttcct tgtattcaca cgcatgcaac 2097121 gatacaataa gcaacatata ttagtttagc taggaagtga agatagtgaa tgtgtttcag 2097181 cttttcatta aaagtacata ctctccccgt gatattgcaa aaacaagatt tcaaggaatc 2097241 ggaaaagcga ttctttatgt atttttgctc tctgtcctgt ttgcaatccc taccgcttat 2097301 tatgtaagta cagggaccgt aaaatcaatg aacggcttta aaactgtttt aaacaaagat 2097361 ttccctgatt tcacaatttc aaacggcaaa cttcaaacgg atgagaaaaa agccacggaa 2097421 tctcaggcaa atggtttcgt tatcgtgttc gatccgacag actcctatgg cactgaacaa 2097481 attgaagcaa agcaaaacgc aatcggcatc cttcagaaca aatttgtttt ggccattgac 2097541 ggacaagccc aagaaatgtc ttactcaatg atgccgtcag agttacagaa aaaagatgtc 2097601 attgcaggtt taaaccaaaa taaagcgatg attgtaactg ttctctcagc tcttattttt 2097661 ctcgtaacag cagcgggaaa atttattgaa gtatcgtttt tagcgcttat cgggttaatc 2097721 attaagaatt cgcagaaaaa acatttatcc tatcatcagc tctggaagct ttctgcttat 2097781 tccatcacac tttcaactgt attctttaca atcatgcggg cactagaagc aaccgtacca 2097841 agtgaatttt tgctgaactg gtttgtcaat tttgtcatcc tgtttctcgt tttaaaagag 2097901 attccgtcca aaaaagtaat taataaaagt taaattatat ttatttttat cctttaagta 2097961 gagagtgtga aagcatttgc attaactttt tacttaaggg atatttaata aaatgtatag 2098021 agcttaaaca gatacattta taaaaaaagc tctacaatta ctcaagaaca agctctggac 2098081 aataatatca gaagtagtaa gatgtaacat gaaagaagtt cttaacagca tttgacatat 2098141 gtttttaaca aaataagaat aatgttaaat tttaactaat agactagtta aaatcatatg 2098201 gcaaaatatt ttgcatcctt tcacaacata tttacataag atagttgcta tttaaaaagc 2098261 caggtaccaa tagggcacct agctttcaga attaaatcat caacaagtta gaattatctt 2098321 ctttccttct attctcatta ttgaactgtt atcttttttg tgggtttatg tatacaaatg 2098381 cagctccctt agctttcccc ttatatactg ataaacctac tgcccaaggt gttcctgtcg 2098441 gttttggtaa tttactgaag taaaactttt tggttggagt tctacttgaa aagtaccctg 2098501 aatattgcgg gccaatgtcc ccaccctcaa ctatagatac accaaagctc ttataattta 2098561 gtttaccgca ttttccattt gtttcggcgt aagcatcaat agatgttgca ctcttagtat 2098621 atgtataagc atctgtaata actcttattt tacaaccaga aataccactt accggttgcc 2098681 aaccactgct tgcagcctct gctttttctt taggtgcaac taccaaagtt aacattagta 2098741 gcaaaattaa aaacacagaa aattttcctt gcttcatttt gtagatcctc ctttaaacta 2098801 ttacataatt atcctaacag atccattgtt cattgtaaat aatggaatac gagttttata 2098861 ttataaaagc ctctttttga tctaattttg cactattttc tattttctat ctgaagttaa 2098921 tgtttagtcg aagaaatcct gtcaaaaaag cgcctgtata aaaaccgagc attcgcagtc 2098981 tcttttcttt tgtcatgaat cgaaatggac aagcatacta tggtataaaa tttcgtatgc 2099041 gggaggaaaa gcgatgaagc gtctcacctt agtatgcagc attgttttta tactttttat 2099101 tcttttttat gaccttaaaa ttggaaccat acccattcag gacctccctg tctatgaagc 2099161 atcagcaaaa acggctgtac aagaaccggc ttataaaacg gtgaaggtaa agccgggtga 2099221 tacggttatg tcgatagtcg gatcagcagg ttctccggat gacattgtaa aggattttga 2099281 agcactgaat ccaaatgtga aagctaacgc cattcaagcc ggaacagcgt ataaattccc 2099341 ggtctaccct taatttaacg ttaatttctt gtcagttcgg cgaagacact gttacaatgt 2099401 aatttgtaaa ataaattcac ataaaccata ctagaattgt tatatctaga agcggcaact 2099461 acaattaagg agcgattgca agtgagtgaa atcacacatc gtacaaaaac gcgtcccgtc 2099521 aaagtgggac ctttaacaat aggcggcaac aatgaagttg tcatccaaag catgacaaca 2099581 acaaaaacac atgatgtaga agcaacggtt gcggaaatta accgtttggc tgaagccgga 2099641 tgccaaatcg ttcgggtagc atgtccggat gaacgggcgg caaacgccat tgcggatatt 2099701 aaaaagcgca tttccattcc tctcgttgtt gacatacatt tcgattataa acttgcgttg 2099761 aaagccattg aaggcggcgc agataaaatc cgaatcaacc ccggcaatat cggccggcgc 2099821 gaaaaagttg aagcggttgt taaagcggcc aaagacaaag gcattccgat cagaatcgga 2099881 gtaaacgccg gttcattgga aaaacggatt ttagaaaaat acggttatcc gactgccgat 2099941 ggaatggtag aaagcgcact tcatcacatt aaaattcttg aggatcttga ttttcacgat 2100001 attattgtca gcatgaaggc ctctgacgtg aaccttgcaa tcgaggctta tgaaaaagca 2100061 gcgaaagcgt ttgactaccc gcttcacctc gggatcaccg agtcaggaac actgtttgcc 2100121 ggcacagtaa agagcgcagc aggactcggc gccattttaa gcaaaggcat cgggaacacc 2100181 atgcgcattt cactaagcgc agaccctgta gaagaggtaa aagtagcaag ggagcttctg 2100241 aaatctttcg gcttagcctc caatgctgcc acgctcatct catgcccgac ttgcggccgt 2100301 attgagattg atctaatcag cattgccaat gaagtggaag agtatatttc taagataaaa 2100361 gcgccgatta aagttgctgt tctcggctgc gctgtaaacg gacctggtga agcgagagaa 2100421 gctgatatcg gaatcgccgg cgcacgcggt gaagggctgc tgttccggaa agggaaaatt 2100481 gtccgtaagg ttccagagga aacgatggta gaagaactca aaaaagaaat tgacattctt 2100541 gctgaggaac actacgcaaa acttgaagct gaaaaagcaa aattaaaaga agaaacacaa 2100601 aaagcttgac gggaacccgt caagcttttt tgtgttagaa aaatggaata ataaatattc 2100661 caagcactaa tgaaacgaca ccgataccca ttgcccaggc tccaaggcct tgagcacctc 2100721 ttcttcttgc gatatagccg acaataatac cagcagctcc caataaaaca ggcagtacaa 2100781 acaatgaaat gatggacaag gctaaagcga tgtaccctat tccccgtcct tcattgacat 2100841 tgccgccgct gcgatcattg tcttggtcat tgctgcggtc agcagcacga taaggctctg 2100901 cgatttcagc agctgtttcc tcaaaaaaac cgtcattgtc gcgggtaata tttgtccctt 2100961 cagatccatg atcaacatag taactgttgt tatcacgctt ttcgtaatcg tttgccacct 2101021 tcaattcccc cttctgtttt attaaaggag cttttatagt ttgatccatt ttgcctgatt 2101081 catgtttgct aaacttttct gttaatgtca attgtttatg ttacacttga agggatgaaa 2101141 ctgaaggagt gtgggcatgt tacgcttagg aatagatatt gacggcacaa tcacggctca 2101201 ggatacattc gtcccttatt tgaaccgttc gtttaatctt tccatttcat taaacgatat 2101261 gacggattat gatttaacaa agctgttaaa cattacccag gaagaatttt gggattggat 2101321 gaatcaaaat gaagcgatca tatataagga agcattgctt gcacagcatg cgaaacagtc 2101381 tctcgatctt ctcaaagagg agcacaagct tatttatatt acagcgagac ggactcattt 2101441 aactgatatt acttatgaat ggtttgacag acaaaacatt cattatgacc acatcgaact 2101501 tgttgggggt catcacaaag ttgaagcggt caagaatcat aacatcgacc tgttttttga 2101561 ggatcatcac gggaacgcca tgatgattgc gaaagaagcc gggataccgg tgattttgtt 2101621 caattcccct tataatcagc ttccgattga ttcaaacatc atcagagtaa acaactggct 2101681 agaagccgtt caatggatga acaacaacaa gcatcactta atacgcgtca ataactgaaa 2101741 aaggagccca aaccgggccc ctttttcata tatacgcatt ttacgcagta gtgttttctt 2101801 ggttttccgc tgtacaatca gggcatgtgc cataaatctc aaatttatgc ccgctgacct 2101861 gatagccatc caaatcatca caaagcttgt ccatcggaca tgattcaatt tcctttgttt 2101921 tgccgcaggc aagacaaata aaatgatggt ggtgatgggt gaatgaacac ttaaatcgga 2101981 agagcttttc accggacagc tcagttgttt ccaaaatccc aagttcttca tataaagaaa 2102041 gatttctgta gattgtatca aagcttaagc ctggataatc atcattcagt gcagacagta 2102101 cgtttttagc ggtaagatat ctgtctgaat cagcaaaaag ctgcagcata tcctcccgtt 2102161 tgtttgtata tttatatccg ttttctttta ataggttcag cgcttcttgg acgttcatga 2102221 agggtccccc ttttcgcttt gcttaagaac gtatcacatg tatgaaaaag aaaatggcag 2102281 ctgtctgtcc agcaagccat tttctttact gcagataaaa ttatacccat aaaatgaata 2102341 aaagtaaatg aaagcctagt ggattgcgtt tttgaatttt ccgcctctcg tttcatgagt 2102401 attcataatt gttatgaatg cattttgatc aacttcaaac acgatcgatt tgagctttgt 2102461 cacttccagc cttgtgacaa ccgcgtaaat tacgtctttt tcttcgtccg tatacccgcc 2102521 tttccccttc agcttcgttg tgccccgacc gagacggtgc aaaatcgcgt cggaaatctc 2102581 atcatactgc tcagacacaa taatgacagc ttttgtttca tcaagccctt ggatcacggc 2102641 atcaatcgtt ttcatcgcaa tataataagt catgaatgag tacatcgctt gctcaggacc 2102701 gaacacaaaa actgcccaaa tgaaaatgaa cacattgatg aacataacga actcacctac 2102761 agaaaacggg agttttttgg tcagcaaaat accgagaatt tctgtaccat ccattgaacc 2102821 tccatttcga ataacaagcc cgacgccaaa gccgagtaaa agacctccga acacagtagc 2102881 caaaataggc tgggttgtaa tggcttctac atggtgaagt gaggattcaa taacggcaag 2102941 cccgacaatc cctataaacg tagagactag aaaggtctta ccgatatatt tatatccgaa 2103001 gatcataaaa ggaatattta atatgacaac gaaaaaagcg aaattcagaa aggggtttga 2103061 cataaagagg tggtctaaaa taagagatac accgataatc ccgccatcaa taaaatcatt 2103121 ggggattaaa aataattcaa tacttacagc cgcagatgca gctcctacca gaatcataaa 2103181 gaccctgaaa ataaaatggg taaatgtttc tttcttatgt tgttttgttg gggtcataaa 2103241 atctcctttc ctgcaataac tattttaaat acattataaa tctattttac cattaaacac 2103301 tgacacattt tactgatttg cccatacatt aagtctggag gtggaatgac cgatgatttt 2103361 atttcaaaga attattttgc agcggcttaa tcaggctact gctgatgatt tgctgaagta 2103421 ctcaaaacaa tacggaatca gcttaacaag atcgcaggcc gttgaagtag cgaacctgtt 2103481 atacgggaaa aatgtaaaca tctttaatga gagtgaacga atgcggctgc tgaaacaagt 2103541 agagacgatt acatcgaaag aaacagctca aacagttaat gaactattca aacaatttac 2103601 aagctaaaaa atgggggtgt tatcccccat tttttattgc tgtaaaatct tttcaagcaa 2103661 tgtatcatca aattgttttt ctttcagcat ttcaatctca aaacggtatg gcggtttttt 2103721 gttcttttta tcttcaccga cgtatggtgt ttcaagaatt tttggaatgt cttttaactg 2103781 ctcatggtga acaacatatt gcagtgcgtc aaaacctatt tcaccaaagc caatattttc 2103841 atggcggtct tttctcgcac ctttgacatt tttgctgtca ttgatatgaa gcactttaat 2103901 acggtcaatg ccaatgattt tatcgaactc atttagcact ccgtcaaagt cttcgacaat 2103961 gttatacccg gcatcatgtg tatggcacgt gtcaaagcac actgacagct gctcattgtg 2104021 tgtaacgcct tcgataatct gcgcaagctc ctcaaagctt ctgccgcatt ctgatccttt 2104081 tccagccatt gtttctaatg caatctggac attttgattc ggatcaatca cttcatttaa 2104141 gccttcaata atttttttga tgccggcttc agctcctgcc cctacgtgag cgccaggatg 2104201 aaggacaatt tgcttcgctc cgatggccgc tgtccgttca atttctgaac gaagaaaatc 2104261 aacacccagc tcaaaagtgg acggatttgt cgtgttgcca atattaataa tataaggcgc 2104321 gtgtacgata atctcgtcaa tgccgttttc ttgcatatgt gcccggcctg cttctatatt 2104381 taagtcttca attttctttc ggcgcgtatt ttgcggtgcg cctgtataga tcataaacgt 2104441 attcgcccca taagagactg cttcctggct tgcagccaga agcatatgtt ttccgctcat 2104501 agagacgtgt gagcctattc tcagcaacag gttcccctac tttcttttct tagattggtt 2104561 tcttctctgt tttttcttga ttttctccat ctcatagctc attttctttt tatacccagg 2104621 cttaaccttc ttcggctttt tcacgagacg atgagcaatt tcatccgctt cattcggcgt 2104681 ttttttacgt tttttgcggc gctgacggtc atcgcctttt ttccattcgc ccttttcaag 2104741 ctctaagtac tcaaattcga tgcccatttt ttcaagtctt actaatgcat cctcatcagt 2104801 aagctcataa atggtcatcg cttgtcctga tgagccggca cgagccgttc tgcccacacg 2104861 gtgaacatag aaatcgagat catccggcag ctcatagttg ataacatggc tgacaccttt 2104921 aatatcaata cctcttgcgg caaggtcagt tgcaatgata tatgtgaatt ccaaatcatt 2104981 gatctgcttc atgacttttt tccgctcacg tggtgttaat ccgccgtgca gcaagccgat 2105041 tttcatgcct ttgccagtca gatactgggc aatatggtca gccgtatttt tcgtgttggc 2105101 aaacacaatc cccaggtatg gattcagatg cgacatgatg tcaaaaagga gcttgtcctt 2105161 gtcacgatgt ttcgaaggaa tgaggatatg ctcgattttc gcagcagtca cctgttttgg 2105221 ctccacatgg gcgtatttcg gattttccat gtatttcttc aagaatggtt tcagcttttc 2105281 cggtatggtc gctgagaaca caagcatttg cagatcctca ggcatgcggg aaccgatgta 2105341 atctacatct gcaaggaatc ccatgtccag cattaaatcc gcttcatcaa taacaagaga 2105401 ttccgcttta tgaacactta acgcctgttc tttgattaag tcagcaatcc gtccaggtgt 2105461 accgacaaca agatgcggct gtattttcaa tttatcaatt gatttttgtt tatcagtgcc 2105521 tccgataaaa catttcgagc gaatctgact tccttcttca ccctgcgtga ttttaagcgc 2105581 ttcctgataa atctggttgg caagctctct tgtcggagcc gtaatgacta cctgaacgac 2105641 atccttagca ggatcgattt tgtttaataa aggcagtaaa taagcgtgag tctttccagt 2105701 acccgtctga gactggccga tgacgctttc tttttttaac actgcaggaa tcagcctttt 2105761 ctggatatca gtcggttcgt aaaaaccaag gcgatgtact gcatctataa taaatggttt 2105821 caattcataa agttcaaatt tcgtttcttt catttttccc agctccttaa agcggcacat 2105881 tatgtgtcca tcatcacatt atacccgatt ttgcttaaaa acaccacgtt tgcaaggcgt 2105941 ttgttttatt cagttatgta aagcaaatac cgcagcccat gcatattcta atagcagaga 2106001 gagctgaaag gaggtacaag tatgttttca ccgcagcagc caatgagaaa ttacccacag 2106061 cccggaccgc cccgccccat gccaaatcag cgaatgatgg gcagaagacc gcctaatatg 2106121 cgaggacctt catttggagc acagcagcaa ggttttcagc aagccggaca atttcttcct 2106181 caggcaaatg ccggagcgag aaatggtgca ggtgcaggcg gaggcttaaa aggaatgctg 2106241 tcaaggttcc tccccggcgg aggaggcgct ggcagcgccg gggttcccgg aattccagga 2106301 gcaggtgcag cagcgagcgg aggtgctggc ctgcaaggca ttcaaaatat tgccaatcct 2106361 gcatcattat ccagtatgct tggaaatgtg caaaaagtac tcggcatggc gcagcaagtc 2106421 acccctatga tccagcagta cggcccatta gtccgcaatc tgccagcaat gatgaagctg 2106481 tacagccaat taagtaaaag tgatgatact gagacagagg ccaatgagga aagtgaaaaa 2106541 caatccgttt cagaagaatc atcagaaaaa gaaaaagaga ctgaaacaaa aacctcagat 2106601 gggaacaaaa aatcaaaacc aaaaagttct tctctcccaa agaaatctaa aacaactgac 2106661 aataaagaac aagaattaaa aacatctgcc ccgaagaaaa aggaagctgc ctctcctgct 2106721 ccgaaaagaa catcaggcag ttcaaaaccg agattatata tttaacattc tttgatatct 2106781 taagtgagat tggctataat gagatcagaa gaatgcaaga atagagccgt ttgattacgg 2106841 ctttttatat tgcctttact cacttcagta ttggaggaca accgaaaatg gacgtaatta 2106901 aaatttcacc gcgcggctat tgctatggtg ttgttgatgc tatggtcatt gccaaaaatg 2106961 cgtcgctaga taaaagcttg ccaagaccca tctatatact cgggatgatt gttcataata 2107021 aacacgtcac tgatgcgttt gaagaggaag ggatttttac attggacggc tctaaccgtc 2107081 tggacatctt aaagcaggtt gacaaaggaa ctgtcatttt cactgcgcac ggtgtttctc 2107141 ccgaagtcag aagaatcgca gaagaaaaag ggttagtcgc aattgatgct acatgtccgg 2107201 atgtgacaaa aactcataat ctaatcttag agatgaaaga aaaaggatat cacgtgatct 2107261 atatcggcaa aaaagggcat ccagagcctg agggagccgt tggcgtagcg ccggagatcg 2107321 ttcacttagt tgaaacagaa gaagatgtaa agaaccttga tatccaatct gagaagttaa 2107381 tcgtgacgaa tcaaacaaca atgtctcaat gggatgttca cgacattatg gagcttgtca 2107441 aagaaaaata tcctcatgtc gaatatcacc aagagatttg cctcgctact caagtgcggc 2107501 aggaagctgt atcagagcag gcaaaaaaag cggacttaac aatcgttgtc ggagacccga 2107561 aaagcaacaa ttcaaatagg cttgctcaag tgtcagagga aatagccggg acaaaagcat 2107621 accggatcgg cgacttaagc gaattgaagc tcgaatggct gaaaggcgtt aataccgttg 2107681 cagttacagc gggagcttca acaccgacgc cgatcacaaa agaagtcatt cgctttttag 2107741 agcagtttga tcacgaagat ccatcaactt ggacaactga acataatata ccgctcaaaa 2107801 aaatacttcc aaaagtaaaa gcaaaaaact gaggctgtaa aagcctcagt ttttttatag 2107861 aaatgtaaat ggatttgtat ctgtttcaga aacaaagata ttcacgccaa actttttatc 2107921 attacacatt gatgtaagtt ttctcgtgac gccttctttc atgatttttt ccgcgtaatg 2107981 gcccggatca accacattta ggccaagcat catcgcatca tgggccacat ggaagtataa 2108041 atctcctgtg acgtaaacat cggctccctt tcgttttgca tgatgaatat acttgtttcc 2108101 atctccgcca agaacagcta cttttttcac catgctgtca gcatccccaa ccattctgac 2108161 accattgacg tcaagcttgt ctttcacaaa taaagcgaat tccttgagcg tcatctcatt 2108221 tttaagggtt ccgacacggc cgagcccttt ttcggcggga gtctgttcga caggatagat 2108281 atcgtaagcg acttcttcat atggatggct ttttatcatt gcattgataa cagccttttc 2108341 gacgctttta ggaaatacag tctcaagcct tacttcatga acaagctcaa gctctcccac 2108401 ttcaccgata aaaggcttag ctccgtccaa tggcttaaag ctgccgattc cttcagatga 2108461 aaacgcgcaa tggctgtatt caccgatatg gccggccccc gcatttccga gcgcggctct 2108521 gacctgctct tcatattcct tcggcacgta aactgccagc tttttcagag gatccgtata 2108581 agtaggtgcc agcacttccg tctcactcag ctctaatgct tcagcaagca aatcattcac 2108641 accgccgtcc gcaacgtcta aatttgtatg agctgcataa acagcaatat catgcttcaa 2108701 acacttttca attaaccttc cggcaggctg atctgttgaa atatgcttta gcgaccggaa 2108761 aattggtgga tggtgtgcaa taatcaagtc aacctctttt tcaatcgctt catcgataac 2108821 gctctctaac acatcaagtg taaccatcac atttttaatt ggtttgttta aggtgccgat 2108881 ttgcaggccg attttatctc cttcaaccgc ataggctttc ggggaaaatt gttcaaacag 2108941 ctggatgatc tgctgcccat ttacactttt agccatgatc gattacctcc tttaacagct 2109001 ccattcgatc ggcgagctcc tttaattttt gtttgttttg ctctgtatcc gccgcttggc 2109061 tgatctgttc ataaatgctt tgagtgtgct gaagctcttg tgtccacttt ttcaaaaaga 2109121 cagcattttt ttcttttgcc aagaaagggc caacgagcat cccggctgat aaagaaatac 2109181 cgtcataagc cgcatccctg tctcccgctt ctgccaccag cacctcatag cactttccgt 2109241 cctcttcaag gattacctca tctatcagcg catatctttc tttataaagc cactccctga 2109301 tatgaacagc atgaatattc ggctgtaaaa tgagccgttc cttccccgtt aatttgtctt 2109361 tgcccgcttc taaaatgtga gcgatcaaag ccccgcccat tccggcaatc gtaatggcat 2109421 cagcttcacc ttttttaatc acttccagtc cgtctccctg ccttacagaa atgtgcgagt 2109481 ttaagcctga tttttcaacc tgccgctttg cagacaaaaa tgggccgtct gttatttctc 2109541 cggcaatcgc cccgctggct ttatgattca gcaccgcata acaaggaagg taggcgtggt 2109601 cagagccgat atcggccatc accgctccat tcggtatgta ctccgctact gtttgcaatc 2109661 gtttagataa ttttaattcg ttcacttgtc atcacaactt ttctcaatca ttttttcctt 2109721 tactatcata taaaaaatca gcccggaatc caagctgaag caaatgattt tgaaattatt 2109781 tcttttgatg cgggtctgca cgcagcagtc aaaaataaaa ggctgtcgag aacatctcgg 2109841 cggcctgtga atgtataaag agaaaaatag ttcttttatt taatttttga cacccactct 2109901 gccatatcat ccagcttatc ggccggaaca agaccggaag gcattccatt accgcctttt 2109961 tcgatctttg ttttaatttc agcgacatct ttcttatccc ctacaccttt taagctagga 2110021 cccgaaacac cttcataatt ttcaccgtgg catgcgatgc agtttgcctt gtaaatttct 2110081 tctggtgaag cgtttgcatc tttcttttca gcagatttgc tttctcctcc gctcgcaatc 2110141 tcccgagagt catcaagtcc ttttactgat aaaaagaaag ttagaccaat tcctaaaaca 2110201 gcgatcagca aaaatggaat aagcgggttc catttcattt cccttccccc tttttgatcc 2110261 ttccccctat gtaaacactt ctaattctaa cttattttta caaaaagtaa atggattgct 2110321 atacaaaagt tttttattca cactttatac aaaattgaat agaaacatgc ctaaatctct 2110381 aatatccttt ttattctatt gtataatgta ttgtatacgc ttacaataga aaatatggaa 2110441 ttagattttg aaatttttca ccacaatgtt catttgcaaa tgacatcatt tttcagtaaa 2110501 ataaaggcat attatccata tatcttttta aaaaaagaag aacggatctt caagacccgt 2110561 tccatcttat tcaaggaaat ctttcaaacg tttacttctg ctaggatgtc ttagtttccg 2110621 caacgctttg gcttcgattt gtcgaatacg ctctctcgtt actccaaata ctttgccgac 2110681 ctcttctaat gttcttgtac ggccgtcatc aagaccgaat cgaagacgca atacattttc 2110741 ttcacgatca gttaacgtat caagcacatc ttccagctgc tctttcaata gctcgtatgc 2110801 ggcgtggtca gaaggtgaag ttgcttcttg gtcttcaatg aaatcaccaa ggtgcgagtc 2110861 atcctcttca ccgatcggtg tttccagaga taccggctct tgagcaatct ttaagatttc 2110921 gcgtactttt tcaggcgtta aatccatatc ttccgcaatt tcttcaggtg ttggttctct 2110981 gcctaagtct tgcagtaatt gacgctgcac acggattaat ttattaatgg tttcaaccat 2111041 atgaacggga atccggatcg ttctcgcctg atcggcaatg gcgcgtgtaa tcgcctgtct 2111101 gatccaccac gtagcatacg tactgaattt ataacctttg cgataatcaa atttttcaac 2111161 ggctttcatc aggcccatgt ttccttcctg gatcagatca aggaacagca taccgcgtcc 2111221 gacataccgt tttgcgatac tgacaacaag ccgcaggttc gcttcagcca atctgcgttt 2111281 agattcttcg tcaccttctt caatcttttg agcgtaggcg atttcttctt ttgcagaaag 2111341 aaggttaacc cgaccgattt cctttaaata catacgaact gggtcattga ttttaacgcc 2111401 aggcggtaca cttaggtcat taaggtcaaa ttcttcttcg gctttggcaa gctgctgaat 2111461 attaggatct tctgtttctt cattctcact aattaattca acaccttgtt cacctaaaaa 2111521 ttcataatac tcatccattt ggtctgattc aatttcaaag ctggacatac gctcagcaat 2111581 ttcttcatat gtcaaaacgc cacgtttttt accagactct gttaattgct cttttacttg 2111641 gtcgaatgtt aattctgtct cgtgggtttg tttatcagcc attatggatc cctccttcca 2111701 aagcttgcaa cgaattctat aagcggtatg attcttattc ggtccattca ggcgttttct 2111761 atgtgaactg cctttaacaa tgtgcgaata atgaaatgac aattcatgat gaggttaagc 2111821 gatctatttg ctcctccgca aggaatcatt gccaataaat gctcctcatc agttctccag 2111881 ttattttaaa gatcggttca atgtaacgat ttcttgagcc aaagaagcag ctcttaaaaa 2111941 atctttttgc ctttctgctt cggctctttc cgcctctttt tcttttatca ttgaccaatt 2112001 tctttgattc aacacttttt ttacataatc tgataactcg gcttcgctaa gctcttgatt 2112061 aacctgaagc attaatatat cggacaagag ctggcttata tgatcatccg tcaccctggc 2112121 catcagatgc tgaggcgtca gctcggctcc ctcttcataa aaagcataaa gataagcggc 2112181 taatgcccgg tgctcatcaa tattaaattg aaaccctacc cggtcaatca cttttttgat 2112241 gacgctccga tctcgaagca tgtgagcgag taacagcctt tctgcatttt catacgccgg 2112301 acgcaaacgt ttttgccttg cttttgtcgt cagatgcgct cgccgcgttt tagtttcacc 2112361 gctattgtca gcaggtttgt tttgcttgct gaaaacagac agctgctcag ttaaagactc 2112421 ctgtgaaagc gaaaactctg aagcaagctg ctttacatag acttcctgct ctagagaccc 2112481 tgaaagcgtg ctgatttctt tcagtacgtc tttaatgtaa gctaggcggt cgccttcatc 2112541 ggacaggttc tttccttttc ggaaatattg cattttgaac gccattacgg tgacacttgc 2112601 gtcaataatg tcgtttttaa atttttcccc gccgaatttt ttgatgtaat catcagggtc 2112661 caatccgtca ggaatcattg caactctgac tttgcagcct tttttttgca gaagctccga 2112721 agcttttaag gtggcttcat aaccggcttt atcagagtca tagcaaagaa tgatttcttc 2112781 gacgtttctt ctcaggatct tgacatgatc atctgtaaga gacgttccca tcgtggctat 2112841 gctttccttt acatccgagc ttacggccga tatgacatca gcaaaccctt caaataagac 2112901 tgctctttcc tgctttctga tatgaaggcg ggccttataa aaattgtaaa gcagtttgct 2112961 tttatgaaag agcggggttt caggactgtt catatactta ggctgctggc tgccaagagc 2113021 cctgcctgag aaagcaacaa cagccccgtg atgatcatgg atcggaaaca tgacacggtt 2113081 tctgaagcgg tcgaaatatc cgcttccgtc ttcgcgtctg atcaggagac ccgctttttc 2113141 catttgcgcc tcactaaatc ccctctttac aaggaatttc gtgataaagt cccaagaatc 2113201 aagagcatag ccaatctgaa attcattaat cagctctttc gtaaagcccc tagaaagcag 2113261 ataatccagt gcctcttgac cttcttttgt atttattaac aaatgatggt aaaatttctt 2113321 caggagctca tgtgcctcag ccattttttg ttctccagaa gactctggcc gggctccgga 2113381 atggactgtt atatcatctg gaaaatcaat ttggtatttg tcagcaaggt gagaaaccga 2113441 ctcggcaaaa gaatagcctt ccatctgcct taaaaaagag aaaacattgc cgcccgctcc 2113501 gcagccaaag caatgaaaaa tctgtttgtc gggcgatacg gaaaacgaag gtgtgctttc 2113561 tccatgaaaa ggacagagtc caaagtagtt tcggccttgc ttctttaatt gaacataatc 2113621 acctatgact tcaacgatat ctgccgactt ttgcacctga tccacaattt catctggtat 2113681 ccgatttccc atcttataac actccgtcgt acattattcg atgctttagt gcaaaatccc 2113741 ttcatcgttc gacaggattt tttgcagcag tgtaataaat cgttctcgat cttctttatt 2113801 caatttttta ggccctttgg catatacgcc ttttcttctt tgtttgccgg aaaaatgacg 2113861 gccctctagg gcaaaatcaa tcgtgtcttc cttgtaaaga cgacctcttt ccgacataac 2113921 agagacattt ctgttcaaca gcagagatgc taatccgatg tcctgcgtca caacaatatc 2113981 tcccggtttc acgtgatttg cgatatataa atcagcagct tctttatgag gatcaacata 2114041 cttccatttt tcttcattgc ttctggaaag ctgataatgt tcaaatgaag cgacaaaaag 2114101 aacttgaact tcatactcgg atgctgtttg taaaatttca tcttttaccg gacaagcatc 2114161 agcatcgaca aaaatcgtct tttcttgttc attaagaaga gtaattctcc atccctccat 2114221 taaactcctg cataaaagca agcaaaatcg cacatccttt attattgtgg atgtatatga 2114281 atttgtcgaa aaatttccgg gagaaattct tgacatctta cccataatag tttattcgta 2114341 tcacacgatc cttaaaccta aaattaatca ttttatcaca attttttatt ataatacaaa 2114401 cttcacaaag atgctattgt ttttcattat tcccttttgg cacagccaaa aacccaggat 2114461 agagcgtcct gagttatatg ttttttgttt tgagatgatg gataatattt gctgtttcct 2114521 caaccgcttt atttgaaaca tcaacaacct ggcagccgat ccgatccaca atcttttcga 2114581 aatactcgag ttcctctttg attctgttga tatttgcata aatcgcttta tcattaagcc 2114641 cgagtgattt taaacgttct tttctgatat gattcagttt atcagggcta atctttaaac 2114701 cgatgcattt tttcggatca acgttaaaga gttcttccgg cggatcaacc tccggtacaa 2114761 tcggaacatt ggcaaccttc aggcgtttgt gtgcgagata ttgagacagc ggtgttttag 2114821 acgttcttga cacgccgatc aaaacgatat cagcttttaa aatccctctt ggatcacgtc 2114881 catcatcgta tttaactgca aactcgatgg cctccacttt tttgaaataa tcttcatcaa 2114941 gctggcgcac ccgccccggt tcgtatttcg ctgttaaacc gtaggctgtt tccattttat 2115001 caatcaacgg gccgataata tcataatata aaacatttgc tttttccgct tcggctatca 2115061 aatattctct gatttccggc accacgagtg taaaacagat aatgccgccg tctgcctttg 2115121 caagtgaaat cacttcattg atagtgccta tatcttcaac ataaggaatt cttcttacat 2115181 gagtatcatc cgccgatccg ttaaattggc tgagtgctgc ttttactacc aattcagccg 2115241 tttcaccgac ggaatccgat acaacataga tgatgcggtt attcatatta tccccccgtt 2115301 agtttgcaat cttataggat ttcattttca gataaactga caagtatttt ggtcatattt 2115361 gtttttgtca ctctgccgat cacttcaaag cctttatcgg tgtctttgat gacaggcagt 2115421 gcatcaattt gtttttctat taagtgcttt gcaatgtcca tcacataatc ctcgcgtctg 2115481 cacaccgtaa tgttcggcat ccttgtcatg atgatgtgaa cagggaccga tgtaagctcc 2115541 tgctggccaa tgctcgctct gagcaagtct tttcgtgaaa gcaccccgac taaaacagca 2115601 tcgcggtcca ccacaaacag agtacctaca tcttctaaaa acatggtgca aatcgcatcg 2115661 tacacagaaa cgttttcgtg aatcactacg gggatagatt gaaagtcttt cacctgaagc 2115721 tttttgagtt tatccgccaa aagctgtgtg ccggtttttc ccgtatagaa ataaccgact 2115781 ctcgggcgcg cctcgaggaa tcctgacatg gtgagtatgg ctaaatccgg gcgcaatgtc 2115841 gccctggtta ggttcagctt ttctgcaata tgctcccctg taatcggccc gttttctttt 2115901 acaatctgca aaatatgttc ttgccgttta tttagttcga tcgtactcac caccttttca 2115961 cttcatagct atgtaaagaa ataacaatcc atattataac gtaaatatct tgtaatcaaa 2116021 caaaaaactt ataaatgggg aaaagacgat taccgatcac acagcaaccg ccttttctct 2116081 ctttatttta caataagggc attcatattc gcaaaggact tgatctcatc cgccaagctt 2116141 accatttgcg ctaaacgatt tgcctttaat gactcattat ccgctataac cattgtatga 2116201 tcgaagtaag catcgatcgg ttcttttaag gctgcaagtg aagcaagcgc cgcctcataa 2116261 tcttttttgc tgaagttttc ctgcagattt tgcttcgctg tttggtaggc atcaaacagt 2116321 tttgcttcgt attcattttc aaacagatca ggctgaatgt ctccgcggac tccttttttg 2116381 ctgatagaga tcactcggcc taacgcttcg gctgtttcct taaagccagg tgcaccaagc 2116441 ttttgctcca gtacttgtgc tttatgcagc gcagagtacg gctcaagctc agagctttcc 2116501 agcacggcgt caatgacatc atgtctgatt tgttcagcat tcaagacata tttcaagcgc 2116561 tgagtgaaga aatccagcag ttcattttct ttatcggttt gaacgaaagt aagcagctct 2116621 tcaaatgaaa ttccccagtt gcggtcaaga agaatcgcaa caataccgct tgcttggcgg 2116681 cgcagtccgt aagggtcctg ggaaccggtc ggaattacgc cgatagagaa gaatgaagcg 2116741 attgtgtcaa gcttatccgc cattgctaca acagctccgg tgaaagtaga aggcgtttct 2116801 ccgcccgctg atctaggcat ataatgttca ttaactgccg cagccacagc ttcatcttcg 2116861 ccaagcattc tcgcatactt ttcgcccata attccttgaa gttcagggaa ttcatatatc 2116921 atatgcgtca caaggtcgaa tttagaaatt tcagcagccc gcttcacatg ttttaatgta 2116981 tcttcatcag cctgaagacg aacggcaagt ttctctgcga ttgatgtgac tctcctaacc 2117041 ttatcagcaa gagaaccaag ctcttcatgg aaaacgatat tttcaagctt cttcacattt 2117101 gcatcaatgt ttagtttctg atcttctttg tagaagaatg aagcatcaga taaacgtgcg 2117161 cgcagcactt tttcattgcc tcgggccaca ttttcaatcg cgtggctgtt gccgtttcgg 2117221 actgtgataa agtgaggcag caggtcaccg tttttgtctt tgacagggaa gtagcgctga 2117281 tgctctttca ttgtcgtgac aagcacttct tcaggaattg acagaaactc ggattcaaat 2117341 gaaccgtaaa gagctgtcgg gtattctact aaatgattca cttcatcaag aaggtcttcg 2117401 tcaactggaa tgctccaatt gttttcagca gccattgttt ccagctgaga ttgaatcatt 2117461 tgctttcgga cgctaggatc agcaataaca tgctgtcctt tgagctgctc ttcataagct 2117521 gaaggtgatt caattgacac ttcatgtccg aggaaacggt gtccctgtgt tgtccgtcca 2117581 gactcaacgt ttgtgatcga aaatggaatg acatcctgtc caaataatgc gacaatccat 2117641 ttgatcggtc ggatataacg caaatcttca tttccccagc gcatgttttt cgggaaatgc 2117701 aagcttgtaa ttaaaccgct caattctggc agaagcgact tcgtttcttg gccggcttgg 2117761 aatttttgca cgaatacata ctctatgcct tttacttctt tgatgtacag gtcttccaca 2117821 tttgcgcctt ggccttttga aaagccgatt gccgcttttg tccagttccc gtccgcatca 2117881 agggcaattt ttttcgcagg cccttttgct tcttctttta tatcatcctg cttttctgcg 2117941 acatccttaa cgaacacagc aagacgtctc ggtgtattga agagtttcac ttcaccgtga 2118001 gtaatatttt tttctttaag ccagcctgtc agcttgtcgc caagctgaac catgctttca 2118061 ttcaaaaagc gcgccggcat ttcctctaat ccgatctcta aaagtaaatc ctgtttactc 2118121 atgagaagaa ccctcccctt taagcattgg gaaccctagt ttttctcgtt cctcatagta 2118181 ggtttttgct acttttctag ctaaattccg cactcttgcg atatagcccg tccgctcggt 2118241 aacagagatc gcacctttgg catcaagcag gttgaaagtg tgcgagcatt tcagcacata 2118301 gtcatatgct ggatgaacaa gtccgttgtc catttgcttg atcgcttctt tttcatatgt 2118361 gctgaacaat tggaacagca tatcgacgtc tgatgtttca aacgtataaa cagaatgctc 2118421 atattcagcc atcatgaata aatcttttac tgtaaaccct gacgtccatt ccaagtcaaa 2118481 cacgttttct ttatcctgga tataagacgc gagacgctca attccatacg taatctctac 2118541 agaaacgggt ttacactcta atcccccgac ctgctggaaa tacgtaaatt gtgttatttc 2118601 cattccgtca agccaaactt cccagcctag acccgcgcag cctaaagacg gattctccca 2118661 gttgtcttca acaaagcgaa tatcgtgctc aagcggatca attccaagag cacgcaagga 2118721 atccaaatac agctcttgaa tgttatcagg tgacggttta ataatgacct ggaactgatg 2118781 atgctgatac agtctgttcg ggttctcccc gtagcggccg tctgccggac gtctggaagg 2118841 ctctacataa gccactttcc acggctcagg accgatactg cgcaaaaatg tatacgggct 2118901 catcgtgccg gctccttttt ctacatcgta agcctgcata agcacacagc cctgactgga 2118961 ccaatgcttt tgcaaggtta gaatcatgtc ttgaatattc atttcaagca cctccacttt 2119021 tctttcataa gttgactgcg gcagcaacca aaaaactccc gtctctatgc ttgccagccg 2119081 caaacatagg gacgagagtt ctcccgcggt tccaccctag ttgctgagaa caaaatccca 2119141 gcctcttttt taaaattgct caagaatgcc tttcgttgcg tgctcatcct tagcttacac 2119201 cgccctaagg tcgctttcat gaggtaaacg caagtacttc tttctctcac tgcaacatat 2119261 tttataataa atgatcatat aaaaagatgg accaaatgtc aacttttgtt ttcacccata 2119321 agatgtttca tgctttccat ttgatctaaa aagcgctttg attttaaata caatcccgaa 2119381 tattcttcgt aatataaatc aatcacttgc tttaattcag cttttgtttc ctcttttaag 2119441 gacacattgc cgagtctcga cagatcaaaa tagtaaaaga gccttaacag ccttgccgtt 2119501 tgcggtttaa tcggtatcct gtaaggatct ttttcaaaac agcggtggca tataaaacca 2119561 ttatcacgaa cagagaaatg aaaggttccg tcttggcttt tacaatgtac acaatgattc 2119621 agctcaggat acaggcccat gacaccgagc atcttcattt gaacaatgaa ggtgataaca 2119681 tccggatctg ttccttcatt caactgtttt aatgattcta atatgaattc aaataaataa 2119741 ggatttggct ttttttcttc tgtgcctctg tcgactaact cagcaacata ggcagcatat 2119801 gctgttaaaa acaagtcttc cctgatgcct ctcatgctga ggatcatttc cccctgctga 2119861 agcgttccga ggcccgatgt tttttgcatt aagaaagaac catacaaaaa gggctggctg 2119921 actgctgata aacggctgtt cggttttttg gcgcctcgtg ccataacacc tatttttccg 2119981 tgttctcttg tcagtaatgt tacgatttta ttcgtctctc cgtaatcatt tgtgcgaaga 2120041 acgatccctt cacattttgt cagcatttcc gcaccttcct caagcaggag cggccaagag 2120101 gtttataaaa ttggataatc aaatcgggct agctcatctt ctagttcttc gggtctttcc 2120161 atgttctctt tttccagttc tttaaaaaga agatacgtat caacatttcc tgtttgagaa 2120221 aatacgttcc aggtaaaatt caacacaaga aacccacctt tctgtagtta aactagctta 2120281 cctaaactcc aaattcttac ctttatcttg accagatgtc ctccatttca tgttaaacaa 2120341 aatttgctaa tgtatccctg ttcctgtgag ataatgacac acacgggaag agattaatat 2120401 tcgtcctctt taaagccaaa atcgcgaagc tgggacattt tattacgcca gtctttctgc 2120461 actttcaccc acaattcaag gtagacacgg gagcccaaca gtgcttcaat atccgctctc 2120521 gctctttttc caacctcttt tagaaggctt ccttttttac cgatcacgat gcctttctgg 2120581 gaatcccgct cgaccacaat cgttgccgct acgtgcacag aaccgttgtc ctgccctttg 2120641 atggattcga tggccaccgc aatgctgtgc gggatttctt ctctcgtcaa atgcagcacc 2120701 ttttccctga ttaattcaga aatgataaat cgttcagggt ggtcagttac ctggtcactc 2120761 ggatagaatt gcggcccttc cggcaaatac gcttcgatct gcgcgagcaa ggtttcgatg 2120821 ttatttcctt ctaaagcaga aatcggaaca atttccttaa aaggataacg tttgcggtat 2120881 tcgtcaatta gcagaagcaa ttggtcggga tgaattttat caattttgtt tacgattaag 2120941 aatacaggcg tagacatcgt ctgcaatttc tcaatgatga attcgtcgcc cttcccgtag 2121001 ccttcctcag cattgatcat aaacaagatc aaatcgactt cttttaatgt attttgcgcc 2121061 actttcatca taaagtcccc aagtttatgc ttaggtttat gaatccctgg tgtgtcaata 2121121 aaaatggttt gtgatgtgcc tgtcgtcagt actccttgca ccttgtttct cgtcgtttgg 2121181 ggcttatcgc tcatgatcgc gattttttgt ccaatgactc tgttcaaaaa tgtagatttt 2121241 cctacgtttg gtcttccaat aatggataca aatcctgatt taaagctttc gttcgtcatg 2121301 taaatcctcc gatgaaaatg cgcctggcaa taattcttcc acagtcattt cttttatttg 2121361 tccttgtaaa ttagtcagta cgacaataac gtcttttgtg caaagctcag aaatcacctg 2121421 tcggcaggct ccgcacggag atactggtcc aggggtgtca gccgcaacgg ccagcatctg 2121481 aaactctgta tccccttcag aaacagcttt aaataaagcg gtacgctcgg cgcaattgca 2121541 catgctgtat gccgcgttct caatattgca gcctctgtac acttttccat ccttggtaag 2121601 aagagcggct cctacttgga atttggaata cggcgcatat gccatatcac gcgcttttaa 2121661 agcttctgtt attaattctt gtctgttcat gtgtacattc ctctcttacc tataatggta 2121721 ccgctatcac tttatatttt acataatcgc gcgctttttt tcacgcccat ttctaaaaat 2121781 gtaaaataaa tgtaagaatt ttcagccatt acagctttgg caaaaaaata agtaaaccaa 2121841 tgatacacga aatcacggca aaaacgcaaa cagccccggc ggcagcgtcc ttggccgctt 2121901 tagcaagagg gtgatgtttg tcagttatta aatcaaccgt atgttcaatg gctgtattta 2121961 aaagttcaag cgaaaacata ccacctatca aaaggaatat aatcatccac tcaataatgc 2122021 tgagctctac aaggaagccg caaatgagaa cagcgcaggc ggctgcggca tgaaattgga 2122081 aattccgctc cgtccgcgct gtttcccata tgccccggcc tgcatgcacg aagcttttga 2122141 agaatcgatt cagctcattt ctatgatctt ttgagtccat aagcgtccag caattccttt 2122201 tgcttagtaa acatctcctc ttcttcctct ttcgtcatat ggtcatatcc taaaaggtgc 2122261 agaaatccgt gtacagctag aaatccgagc tctcttttaa aagaatgatt atactcctct 2122321 gcctgctctc ttgtgcgatc ggcactgatg ataatatcac ctaaaaccgg aggcatttcg 2122381 gcgcccacga tttcgatctc gccttctccc tcttcttcaa gagcaaatga gatgacatct 2122441 gtcggagcat cctttccccg gtattctttg ttaatctgat gtatgtcatc attggaaaca 2122501 atcgtgacag aaacttcagc ctgatcctga acgccttcac gctcagcggc aaattgaagc 2122561 agattttcta cttctttgag catctcttct gagacgcttc ccgtttcatc aacgatatca 2122621 atcagtaaac tcatctattt caccttctta gtagcctccg gatattcaat ccgggagtgg 2122681 aaaattcctt ttaatgttgc acagagcgtt tttgcgattg tatccagctc tttaaatgtc 2122741 aaatcgcatt cactgaactg tccgtcctga agcttatcgg atataatacc ccggacaagc 2122801 ttttcaattc gttcaggatt tggattgtgc atggatctga cggccgcttc aacactgtcg 2122861 gccactgata taattgcggc ttcctttgac tgcggcttcg gtcccggata acggaactct 2122921 tcctctgtaa tctggtcgcc tttttccttc gctttatagt aaaaaaactt taaaagcgag 2122981 gttccatgat gctgctcagc aatatcgaca agctctttcg gaaatttata gcttctcagc 2123041 atattcgcac cgtctgtcgt atgcgagata ataatatttt tgctcaactg aggtgacagc 2123101 ttgtcatgcg gattgtcaat attcatttgg ttttcaataa aatattgcgg gcgctttgtt 2123161 tttccgagat cgtgataata tgcgccgact cttgcaagca aaccattagc cccaaccgct 2123221 tcacaggctg cctctgataa attggcaacc attacactgt gatgatatgt acctggtgtt 2123281 tccgtcagta ttttgcgcaa tagcggatgg ttaggattag acagctcgag cagcctcatg 2123341 gtggataaaa tgccaaagcc cgtctcaaaa aacggcatca gaccgatgat caatacagat 2123401 gaagcaaacc ccgacacaac ccccatgagc attaacgtgc cgatttcaag acccgacagc 2123461 gcagtgttct ggatcaataa taaggataga acgacaacca tattaataaa cgccacgaaa 2123521 agtccggtct gcaaaatctt tgatcttgca ttgtgttttc ctaaaaataa tacacctgaa 2123581 atgccgctga tcaaataata aatccctatg acataattga atgttcctgt cacaccctga 2123641 ttaaacatca tacttccgca aatcgcaaga atgatacttc ccaaaatggc aatgcgttca 2123701 ttcatcagca gtttgattaa gatggcgccg gccgcaatgg ggaccagata gccgatatta 2123761 ttatactcca tcttctgaaa caaactgaca acctccatga tcacaagcaa aagtgttgtg 2123821 attatggaga ataacagaat ggattggttt ttaaacttca gattttgttt ctgtttttca 2123881 aaataatata caagtgttgc aatgaaaagt ccgatcataa tcaatagccc gctgatcggt 2123941 ttaaagagat ttgagttatt taataacccg gtcagctcaa gtttcctgta cacttcccga 2124001 tcaatgaggt cattttcttc cacgagcact tgcccctgtt tgatttgaac ctgctggaca 2124061 ttatctgagg cttcctgccg ttttgcctct gttgctttcg gatcgaagac gtaattcgga 2124121 ataatagcaa aacgcccgat ttctgtcgcg gctcccaagt atttagacgg aatagaattg 2124181 ctctttagct ctttttctac cttatccttt gcatcagata gtttatccga agggatttca 2124241 ctgctcatga ccgtatttac cgcggtaatg accgtatctc tgacaaaaga aaagtcttca 2124301 ctgtctgctt tcagcaatgt cttgatggaa tcctccgata tagaatcatt cacatctgat 2124361 gtcaatttgt cctttacaga tttgaccatt gatttttccg atggtgattt actgccttct 2124421 tccgatgatt ttttcacttc actaatactg tcgaatattg atgacacaag gtcaatccga 2124481 ttgtctgtat attctttttt taatgtatat tgatcttcaa ccgcgtcctc agcggcttgc 2124541 tttttttcct ctgtggcttt ttgatcttct acggttgccg gagcgtaaat ggtcttgtcg 2124601 ctgactgaaa acaggtctaa atcaagtgtt tccggcttaa catgtacaaa gagcaaagca 2124661 aacataatgg cagccagcag aagatacagc agtacatgca tggagcgggc atttttaaaa 2124721 ctgctccatt tttttgagct gcttttggtc ttagccttct ttttcaacac aagaacctcc 2124781 tcttgaaaca tcaagcccat aagcaatcat aaaaatgacc cgataacgcg cgatcgggtc 2124841 attcagcatt aattttgctt atcgtatgct tcaataattt tcgcaacaag cggatgtctg 2124901 accacgtctg tctggtctag ctcaatcata gaaatgccgt ctattccttt cagcatctcc 2124961 ttcgctactg caagtcccga tttgacgcct ttcggcagat caatttggct aacgtcacct 2125021 gtaatgatca ttttagagcc aaaacccagt ctcgtcaaaa acattttcat ttgagcaggc 2125081 gtggtattct gtgcttcatc aagtataaca taagcatcat cgagcgtccg tcccctcata 2125141 tatgcgagcg gagcaatttc aatgatgcct ctttccatca gacgttctgt atgatctgcc 2125201 ccaagcacat catggagagc gtcatacagc gggcgcaaat aaggatctac tttttctttt 2125261 aggtcacctg ggagaaaacc aaggctttca ccggcttcca cggcaggtct tgttaaaatg 2125321 atttttttga tatgtccgtt ttttaaagca tggactgctt ttacgacagc caggtacgtt 2125381 ttcccggttc ccgccggacc aatgccgaat acaaggtcat tccgcttcat agcggccacg 2125441 tattcccgct gtcccattgt ttttacacgg attgatttgc cttttgcgtt ttttgtaatt 2125501 tcttcttcat acatgctttc aaagtattca agttcattct tctttgccat tttgatggcg 2125561 taaatcacat cacgttcaga gatctctatc cccttgcgaa ttaaagcgag gagcgatccc 2125621 agcagcctgt ctgcaatctg aaacgattca tcatcgcctg aaacataaat cgtctcgccg 2125681 cgcgtaatga tatttaaatt cagatctttc tccatcaatt tcaaaaaaga atcttggttc 2125741 ccgaagagtg aaagcgcctc gtccgggttt ttcagttttt gattcatcgc aagtaaatgt 2125801 tctgtcattc ttcagtctcc ctgacaatag gtgtggtttg aacgatatct tctataactt 2125861 ggtagagaat aatcaacttt actttaccat tctcaacagt ctggtgcaaa actttttcac 2125921 ttttcacctc gccgttttcg cctattttat cctctacatc ctgtttaccc aatttaatgc 2125981 cttcttgaac tgcttcttct tttgtatatt ttcgcaaagc ctcttcactt tctctcgttt 2126041 gctctttgac ataggataca gggagcttaa atccgagaaa atgaagcgaa tgcttttctt 2126101 gttctgtttt tggatgcttc aattcctctt ttttaaacgt catcccccag atcgggattg 2126161 ccaaagaacc aaaagaaagc ttgtgctttg tccttacttt gcccgtatag acgttaaata 2126221 atgtttcaag cgggactgtc acttctgatc tataccaggt ttctccataa atttctgctt 2126281 ttgaggcgac ttcctgctga tggtcttcgc tgccgatcag tcccgaaaca agcagctgtc 2126341 ccttttcaac atgatcgtgt atggcggcca tgggctgtcc tttttgcaca aacattctcg 2126401 taatggttgc tttctttttg gcgacaatat tgcgcgggct aacatatttt tctttttcgg 2126461 gctcattttt ctccacaact ttcatatgaa tggtcgtccc cttcagatca actccgaccc 2126521 aagtgatatt gtctattcca ttggttaatg atttctgtat tttttcgggc gacatcatta 2126581 aaaactgcag acggcccttt ttgacgccga tttcattaag atgctgcctc atttgatgtt 2126641 ctgtttcagg cttagcgcct gtcacatcaa ttttccacac catattggac agcaaaaaca 2126701 aaagaatgaa aaaaatcgca aaaccgatcg taaaccctat attcagcttt gatttcagca 2126761 acaggaaggg aaatcccttc cgattgataa atcgggcttt acatttaaat ttacttctta 2126821 cccgccgaaa ggcatgtaca tcctgaagct gtatatataa cgatacggct tctttctttt 2126881 ttttgacatg aaagaccgga atcccctgtc ttgtgcattc attaaggagc cgctcaatcc 2126941 ctcttcccgt caattcaagc tggaccttac ccgaaaaaaa agacagccat ttatttttca 2127001 caacatttcc ccctcggctt tatgactcaa catatcgaac gacatcaatc gtaccctcca 2127061 aaagtatctc ttccggaaga atcgccttga tgacaaaatt tttaccagat atgatgcact 2127121 ggccctgctt cagcatcagc cgcacttcat tctcactgaa aagcaaaagg cctctgtggt 2127181 tttctatgta gatatgaagt ctgccaacca ttgtaatcct cggcagatcc atcataacgt 2127241 ccgggggaat ttccaatgct cttgtcagcc aagctttcat acgattcttt ctttgcccca 2127301 tacaaaaaga accccctttc atctcatatg tatgatttga aaggaggttc taacacttta 2127361 atttttacgg gccgggcgca tcgtacggtg aggttttttc gcccgtggag gtccgaacac 2127421 ctctcctaga acgatcccct gtacgacggt gtctttattc acctgaagca ttttttgttt 2127481 tgtgtatact gttttttgtt tggcagcagc aagatctcgt tccagccctt tcaggtttct 2127541 tgctgtttcc ctgcgtcttt cttccgcttc ccgtcttgcc tgttccatac ggttagggat 2127601 aggtgcaggg gcatcttctt ttgactgctt cttttgagga gaagcagatt gcacgtgttg 2127661 aggttttttt cttttttggc tgttttgctt ttcttctttg ctctttttgc cgaaaatcgc 2127721 agaaatgatt ccgatgatcg ctgcaataat aagcggattg gtcagtaaat cttccatcag 2127781 cgttctccct tcttagagag attatgattt gcggtcttca tccgaagggt ctttcgtcag 2127841 cttgccgaat gaatcacgca tttctgtgtc agcatcgatg ttcttgatat tcatgtaatc 2127901 catgacgcca atattccctt cacgcaaagc ttctgccatc gcaagcggca cttccgcctc 2127961 ggcttctact actttcgcgc gcatttcttc tacgcgggca cgcatttcct gttcttgagc 2128021 gacagccatc gcacgtcgtt cttccgcttt tgcctgcgcg atgtttttat cagcctcggc 2128081 ctgatcggtt tgtaaaattg ccccgatgtt tttgccgata tctacatctg caatatcaat 2128141 tgagagaatt tcaaacgcag ttcctgagtc caatcctttt ccaaggactg tctgagaaat 2128201 catgtcaggg ttttcaagca cttttttatg attatcagat gaaccgattg tagaaacgat 2128261 tccctcacct acacgagcta caatggtttc ttcccctgct cccccgacga ggcgctcgat 2128321 attcgctctt actgtgattc tcgctttcgc tttcacttca atcccgtcca ttgcgacgcc 2128381 ggcaatgaac ggtgtttcaa tcaccttagg attaacgctc atttgaacag cttccaacac 2128441 gtcccggcct gcaagatcaa tggcagcaca gcgctcgaat gtgagttcaa tgttagctcg 2128501 ctgagcggcg ataagcgcgt tgacgactct gtcaacatta cctccagcca gatagtggct 2128561 ttcaagctgg tttgttccaa cattaagtcc cgctttatgc gctttaatca gcgggttaac 2128621 aacccgattc ggaatgacgc ggcgaagcct catcccaact agagtgaaaa tgctgatttt 2128681 cactccggct gccaaagctg aaatccaaag cattacaggc acaaatgtaa aaaatactgc 2128741 caaaacaatg atcgctactg cgacaattgc cagaatcata agtgttgacg gatccatata 2128801 acttctcctc gtttctattt aaatttctct cacgacaatg cgtgagcctt ctacttttat 2128861 cacttttact tttttatctt tttctgtaaa cgatccctcc gatacaacgt caaggcgttc 2128921 atcatcaata atcacggtac cggaaggacg cagcggtgta aaggttatac ccacttttcc 2128981 cattaagtcc gtgcgcgttt gatttgaaac gtagccgctc tccgtgtttg tagaatcatt 2129041 taatatcaat ttcttaaaga atttcatacg ctttcccaac acccttgtca gtaaaataaa 2129101 agctgtaatc gaaacagctg aggcgatcaa gagagaaacc gccatgacag tgaagctccc 2129161 cgcggctaaa aacaggctcg caataatcgc tcccaagccc agtaatccaa tgattcctcc 2129221 gggaagaaaa atctcaagca gaatgagaat cacccctgct ataaagagga gaaccgtctc 2129281 atacccggca aggccggctg caagatgccc gtaaaagaac agcaataacg caatgagtcc 2129341 agccgttcca gggaggccga cacccgggga aaaaagctct accgtcagac ctaaaaaagc 2129401 gattgtcagc agaataggga caatgaccgg attcgtcagc catcttgccg tcttttccgc 2129461 aaagctctcc tttgcatagc tgatctgcgc cttttcgaac ccaagcttct ttacgagcgt 2129521 ggacaaattg tcagcagtgc cttctgaata gcctacctca atcgccttgt ctgcgttaag 2129581 tgtcagcaga tctcccttag gcgcgccaac ttccttggca tctatatctg ggtcagccat 2129641 tgcgagcgca tattttggat cgcggttatt tttcactgcg gcatcttcca tctctgccag 2129701 ccaaagtgat tgagcttttt ggtcagcggc attgccttgg ccatcaacaa tcgcggcggc 2129761 tcccattttt ccgccaggcg ccatataaat gtgatctgct tgaagtgcaa tatatgcacc 2129821 agcagacaac gcgcgtttgt tgacatatgc agttacgggg atctcgcttt cggttatcaa 2129881 atcggccata tcaatagcag atttgaccaa tccccccggg gtattgatat caagaataat 2129941 atggtctgca tgtgcatcct ttgcgtcttg taacgaacgg gacaaaaacg aggcgagacc 2130001 ctgttcgaca tttttttcaa ccgggatcac ataaacagtt tgtttttctg cttttgcgtt 2130061 cagctgtacg cctaataaag aaagtaaaaa tatacccaaa agagcagcac ggaatccttt 2130121 gatttgaagc aagggcggtg tatccctcct tccttttata ataagtgcct tctcttcata 2130181 cgtaacaaat gtatcaaagg tttcattttt ttatgtataa aaaaagacat ctctcttaga 2130241 aagatgtcct tttctttgcc atttaagaca gttgactgct cacaagctta ttaattaaac 2130301 ttccgtcagc tttacctttt actttaggca taattgcccc catcactttg cccatgtccg 2130361 cttttgagct cgcaccgacc tccgcgatgg tttcatttac gattgtacgc agctcttctt 2130421 ctgacagctg ctcaggtaaa taaacttcta aaatgtccag ctctttttga actttatcta 2130481 ctaaatctaa acgattagcg tttgaaaatt cctggaggga gtctttacgt tgcttaagtt 2130541 cacgagaaag gacagtgagt tcctcatcct cggtcaaact gtctttctta agcttaattg 2130601 cttcattttg aagtgaagcc ttaaccattc gaacgacagt cagtttgtct ttctcacggt 2130661 ttttcatata cagcttcata tcctggttga gacgctcaag aagactcata aatccaccct 2130721 cttttagaat ttgcgttttc tagcagcttc agactttttc ttgcgcttta cgctaggttt 2130781 ttcataaaat tcacgctttc ttgcttcttg caaagtacct gtctttgata cactgcgttt 2130841 gaagcgacga agagcatctt caagcgattc gttttttcta acgaccgttt ttgacattct 2130901 ctttccctcc ctccgaatac accaatcgac tacctttaag ttacacatat aaacatgtac 2130961 tttgacatta taatataagc catcagtcag gtcaactaag tgagttcact tttccgtcat 2131021 gagtgcgact gcctgtctat ataatgaaag aaaggggttg gtgaatagga tgttaattct 2131081 gattagcttt actgctctta tattattctt tctcgcaggc atgaacatgc ttcgaaaggg 2131141 cttaatttca atggcgtact caaaaattga agaacgtttg cttttattta cagaccatcc 2131201 gttaaaagcg tttcttatca gtattgtatt tacggggata cttcagagca gctcagcctt 2131261 tatggtcatt gtcatcggct ttgtaagtgc gggcgttctt tcttttaagc ggacgatccc 2131321 gatgattctg gggacaaatg ttggctctac ttttacaact gaatttattg ctatcaaaat 2131381 ggatattgtg atttgggttc ttttaatagg aggtttattg ttttttctga ctggcaggta 2131441 tcctttgaaa cagctgggaa caagcttcct tggactgggc atcatcttct tttgcatcag 2131501 cggattcagc catcttgccg ggccgctgac aaagctgaaa acgggcgccg acgttctata 2131561 ccatgttaac gattcaaact ggtccgcttt gctcatcggc atggtgttaa ctgccatcat 2131621 tcactccagt tctgtctgta tcggcatttt gatgagtttt atgaatgaag ggattatcgg 2131681 actgacacag gcgatgagcg tcgtactcgg atcaaatatc gggacatgca ttacagctgt 2131741 catggctgct gtatccggcg gatatgcggc gaaacagaca gcatatgccc atgtggtatt 2131801 taacgtgcta ggggtggctc tagtattgcc ttttctgacc gcagcgaccg gctttgtaga 2131861 gcagttatca cctgatcccg cacaaaagat cgcgcatttc agccttttat ttaatgtggt 2131921 gacagctctt ttatttcttc cgcttacaaa cttgttttac cgattgattc accttcttat 2131981 cccggctaaa taaaaaaatc ggtacatttt aatgcaccga ttttttaggt taagaagaca 2132041 aacgcatgtg ttcagttatt tcatcctcaa ccacacggac aaactgtcct tcgttgtaag 2132101 gataacctgc ttttaggatt ttgactttta cgattttgcc gatcatatct tccgtacctt 2132161 tgaaaacaac cttcatataa ttgtctgtgt aaccgacaaa catattttct tcttctgttt 2132221 ccttaaacgc ttcctcaggg ataatctcaa gcacttcatt ttcatactga gaagcgtatt 2132281 cttttgcaag ctggtcagaa agagcaatca ggcggtgcac acgttcgttt ttcacgtttt 2132341 catccacttg gtcttccatt cgtgcagctg gtgttcctgt acgcttactg taagggaaaa 2132401 catgcagctc agagaattta tgttctttaa taaagttata ggtttccata aattcttctt 2132461 ctgtttctcc agggaacccg acgatgacat cagaagtaac agctaagcct ggcagtgctt 2132521 ttttcaattt atttaaacgg tctgcaaaga attccattgt atatttgcgt ctcatccgtt 2132581 taagcactgt gtttgatccg gattggatag gaatatgcaa atgattcact atcttatctg 2132641 agcggtctaa gacctcgatc acttcgtcag tgatttggct ggcttcgatt gaagaaattc 2132701 tgatccgttt cacgccttcc acacgggtgt ctaattcgct caaaagcttc gcgaagttgt 2132761 aatctttcat atcttcgccg tagccgcctg tatgaatacc cgtaagaaca atttccttat 2132821 atccggcatc gacaagctgc tgcgcttgtt taatgacttc ttcagggtcg cgggagcgga 2132881 gcaggcctct cgcccacgga atgatacaga atgtgcagaa attattgcag ccctcctgta 2132941 ttttcaatga cgctcttgtg cggtccgtga aagcaggcac atcaagctct tcatatactc 2133001 ttgctttcat gatgttgctg acgccattaa tcggctggcg ttcttctcgg tattggtcaa 2133061 tgtagccaag cattttttca cggtcctgtg ttccgactac aatgtcgaca ccggggatcg 2133121 ccataatctc agcaggtgag gtttgcgcgt agcagcctgt gacacagatg acaccgtcag 2133181 gattttgacg aatggcgcgt ctgatcactt ggcggctttt tttatctccc gtatttgtaa 2133241 ccgtacatgt attaatgaca tatacatcag ctgtttgttc aaagtctctt ctttcatagc 2133301 ccgcttcttt gaaaagctgc cagattgctt ctgtttcata atggttgact ttacagccaa 2133361 gcgtatggaa agcaacagtt gccattactg atcacctctt aataactctg tttgataaga 2133421 aatcgcactc aacgcgtata gcggagcggt ttctgtcctt aaaattctcg gtccaaggcc 2133481 gcacgtcaca ccgtcttgct ctgtgagccg ttcaacctcc gcttctgtta aaccgccttc 2133541 gggaccaaat acgatcaata gagatgatcc tttcggaagg ctgcttacaa tcgcgctgaa 2133601 tgcgcttatt tccccttgct tcgatgactc ctcgtatgca acgacacatt tatcgaaatc 2133661 ctgcatcctt tgaagaagct gctgaaaaga atggacatcc atcactcgcg gcacttcgtt 2133721 acggtacgat tgctcagccg cttccttcgc aattttcgtc catctttccc gctttttctt 2133781 tgcctttttg tcatccagct tgacaacaga acgcgcggct tggaaaggaa taaaggcatg 2133841 agctccgagc tcagtcccct tttggataat ccattcaagc ttatctcctt tcggaaggcc 2133901 gctcgcaata tagaccttta tcggaagctc tctgttttca ttcgtccatt ctatcacaag 2133961 gcaggacact ttatctttgg aaacagattg aagttcacat tttgcctcga agccgtcttg 2134021 agagcagcag ataatctgat ctccctcatt cattctcatc acgttcacaa tatgatgaac 2134081 ttcttcgccg gtaatcgaaa aagtcggcgc ttcctctatt tgctgcttcg tgagctcgat 2134141 aaaatatcgt tgcatacgct gtgacaccta ctaactgtta ttttttcgca ataatgctga 2134201 cccaatcttc cattgaaagg atttctacaa tggtaaagcc agcttgttcc agtgcttctt 2134261 ttacttcttg ttttttatga ccgatgattc ctgacgtaat aaagtgaccg ccttctttta 2134321 acaggctgta cgcttgtgaa gtaaagcgaa gaatgacttc agccaaaatg ttggccacaa 2134381 tcacatcatg ttccccttca atcccgtcta acaaattgtt ttgcttcact tgagcaatat 2134441 cgctgacttt gttcagcttg agattgaggc gtgcactttc tacagccacg ggatcaagat 2134501 cgtaggcatg aaccgattca gcctcaagca ttgcagccgc aatacttaaa attcccgaac 2134561 cagtgccgac atcaatcacc ttatcaccct tttgcacaaa gcgttcaagc gcctgaatgc 2134621 agagtacggt tgtcggatgt gtccctgtgc cgaaagccat tcccgggtcc atttcaataa 2134681 tcagttcatc agtatggacc ggcgtatatt cctcccacgt cggcacaatt gtaaactttt 2134741 cagaaatttt cacaggatga taatactttt tccaggcagt cgcccactct tcttcattta 2134801 cttcagaaat agtgatgtgg tttctgccca aatcaatatt gtaaagaagg agattattaa 2134861 tcgtttcttt gatgccgtct acagtttcgc ccagaaaact gttaaccggc agatatgctt 2134921 tgacaatgac accctcatct gggtaatcat tggggtcgag ctggtagatt tccccgtaca 2134981 cattctcacg ttctttaatt aaatcaagcg ggtcctctat cacaacccca cttgcaccag 2135041 cttcatgcaa tatatttgag ataggttcga ccgcttcatg tgttgtgtga atgcttaatt 2135101 cggaccattt caaaactacc aactcctcat ccaataatta atcgccttta aacgcgcgtt 2135161 ttaccttgtc aaagaaactc atttcctgtt cgtcaggcag gtttccgctg acttcggcaa 2135221 attcgcggat aatgtctttt tgtttatcag tcagatttgt cggcgtaacg acgcggacga 2135281 cgatatgctg gtcaccctgt ccatagcctc tgacattttg aacgcctttg cctcttaatc 2135341 tgaatttcgt tcctgtttgt gtaccggccg gaattttcaa tttcactttt ccatgcagcg 2135401 tcggcacttc tacctcatct ccaagagcag cctgagcaaa cgttaacggc atttcacagt 2135461 aaatatcatc gccgtcacgc tcgaagaact cgtgtgcgcg tacatggaac acgacaaata 2135521 aatccccggc agggccgccg tttattcctg gttcaccctg tcccgagaga cgaagctgct 2135581 gcccgtcatc tacaccggct ggaattgtca cattgatttt cttgcgtttt ttgatttttc 2135641 ctttgccgcc gcagtccgca catttgtttt taatgatttt gcctgtacct tcacagtggt 2135701 ggcagacccg tctgttaacg acttttccaa acggtgtatt ttgctccacg tttaactggc 2135761 cggagcctcc gcagtgggag catgtttctg gatttgttcc aggtttcgca cctgagcctt 2135821 tacatgtttc gcacgtttcc tcgcggggaa tttcgatggt tgtttcttta ccgaaagccg 2135881 catcctcaaa cgacagggtc atcgtatact gtaaatcagc accctggcgc ggagcgtttg 2135941 gatctcttcg tcttgtgcct ccgccgaata tacttgagaa aatatcatcg aaaccaaaac 2136001 cgccgaaatc gccgccgcca aaacctccgc cgccgaagcc ttggttaggg tcagtgtgac 2136061 caaattgatc gtaatgcgca cgtttttggt catctgacag cgtttcgtat gcttctttta 2136121 cctctttaaa tttttcatct gatccggctt ctttgttaat atcaggatga tatttttttg 2136181 acagcttccg ataagctttt ttaatttcat cctttgaagc gctcttactt actcccagca 2136241 cttcatagta atcacgctta ctcatctcgc ttcactctcc cgaatttctc acataaatta 2136301 gattgtatca ttttgaatta tgatttttca attcctttta tcccgggcaa gaaaaaaagt 2136361 caaagccaag agatgcctga ctttgacttt ctaatcattg aatcagatta tgaaatgtgt 2136421 tcttttcggt cagctccgga agcggggctg acactaaaaa gaacttattt tttgttttgg 2136481 tcgtcgttta cttcttcgta ttcagcgtcg acaacgttgt catccgcttt gccttcagcg 2136541 tttgctccgc cttgagcttg ctgtgcttta gcagcttctt cataaagctt catagaaagc 2136601 tcttgaacga ttgtttgaag ctcatctttt ttcgctttga tctcttcaaa ttcgtttttc 2136661 tcaatcgctg cttttaaagc gtctttggca tcgttggctt ttttcacttg ttcttcgtcc 2136721 actttgcctt caagatcttt taatgttttc tcagtttgga aaacaagctg atctgcttcg 2136781 ttgcggactt cgatttcttc ttttttcttc gcatcagcgt cagcattttc ttccgcttct 2136841 tttaccatgc gttcgatctc ttcatctgag agacctgaag aagatttgat tgtaatgttt 2136901 tgttcttttc ctgtgcctaa gtcttttgct cttacgttta cgataccgtt tttgtcaata 2136961 tcgaaagaaa cttcgatttg aggcacgccg cgcggtgctg gcgggatatc agtaagctgg 2137021 aagcggccga gtgttttgtt gtcggcagac attgggcgct caccttgaag aacatggata 2137081 tcaacagctg tttggttatc agcagcagtt gagaacactt gagatttgct tgttgggatc 2137141 gtcgtgttgc ggtcgatcag ttttgtaaac acaccgccca ttgtttcgat accgagagaa 2137201 agcggtgtaa cgtcaagaag aacaacatct tttacgtcac ctgtgataac gccgccctga 2137261 atcgcagcac caagcgctac aacttcatcc gggtttacgc ctttatgcgc ttcttttcca 2137321 gtttcttttt tgattgcttc ttgtacggca gggatacgag ttgatccgcc gacaaggatg 2137381 actttgtcga tttcgcttgc agaaagtcct gcatcttgaa gcgcttgacg gacaggaccc 2137441 attgtgcgct ctactaaatg agaagaaagc tcttcgaatt tagcgcgagt taatgtaagt 2137501 tcaaggtgaa gcggtcctgc ttctccagct gtgataaacg gtaaagaaat ttgcgtagaa 2137561 gatacgccgg aaagatcttt tttcgctttt tcagctgcgt ctttcaaacg ctgaagcgcc 2137621 attttgtctt ttgacaaatc aatgccgttt tcttttttga attcagacac cagatgatcg 2137681 atgataactt ggtcaaaatc gtccccaccc agacggttgt cgccggcagt tgaacgaact 2137741 tcgaatacac cgtcgccaag ctcaaggatg gaaacgtcga atgtaccgcc gccaaggtcg 2137801 tatactagga tcgtttgatc ttcatctgtt ttatcaagtc cgtatgcaag cgctgctgca 2137861 gtcggctcgt tgatgatacg ttctacttca agacctgcaa ttttaccagc gtcttttgtt 2137921 gcttgacgct cagcatcgtt aaagtatgca ggaactgtga taactgcttt tgatactgtt 2137981 tcgccaagat agctttcagc gtatgattta aggtgttgaa ggatgatagc agacacttct 2138041 tgtggagtgt aatcctttcc ttcaatttca actttataat cagtacccat atgacgtttg 2138101 atagacataa ttgtgttagg gtttgtaata gattggcgtt tagccacttc ccctacttga 2138161 cgttcgccgt ttttaaatgc aacaactgat ggcgttgtgc ggtttccttc agcgttagca 2138221 ataactttag gctcgccgcc ttcaagcact gccacacatg agtttgttgt tcctaagtcg 2138281 attccgataa ctttactcac ttgaataacc tcctgctatg taattattga ttcactttga 2138341 ccatggaagg gcgaatgacg cgatccttca gcttatagcc tttttgcatt tcctcaacaa 2138401 caatgttgga gccgtagttt tcgtcttcag cctgcataac agcttggtgc agattaggat 2138461 caaattcctg ccctacagct tcgatggctt cgacgccttc ttttttcaag gcttctacga 2138521 gctgacggtg gaccatttcc attccctgga gcaaactttt cgtctgttca ttgtcggctt 2138581 caacctgaag cgctcgttca aaactgtcaa gagccggcag caaatcagtc acgatatttt 2138641 gagaacggta tttttgggac gcttccatct ctaaacggct gcgtcgttta tagttttcaa 2138701 agtctgcttg aacacgcaaa agtttgtttt ctttttcctc aagcaaacct tgcaattcgt 2138761 taatttggtt ttgaagaagt tcgctttcat ttgtttcttc ctgctgttca tcagcggcag 2138821 cttgttcttc aatgatttct tgctcttctg tttcgttttg ttcaacggtt tgtttttctt 2138881 ctgacattgt gttcacctcc ctcaaagtgt aaggagaagg acaggtgctg cccttcgata 2138941 aaatttgcca aaattccctt attcatcata cagacttgtt aatgcttttg acaagtccga 2139001 agtcacatgc tgaagcaggc tgacaaccct ggaataattc atgcgggtcg ggccgataat 2139061 cgcaattgag ccgatctgct tctggtctac ggaataagaa gccgtaatca gactgcaatt 2139121 ttccatctct tcatagtcgt tttcttttcc gattttaatc gaaattcccg tgtgcgggga 2139181 ttgaaccagc tttaaaacat cctgttcttt ctcaattaat gaaagcagcg accgaactcg 2139241 ggtgatatca tggaactcag gctggttcag catattgatt ttcccgccaa aaaacaactt 2139301 ttcaacgtga tttgtggaat gaaaggttga acgaagcgcg tcgagtatat tgtcatagtt 2139361 tttaatgtgc tgtcttaggt acatgacaac ttctttaaat atgcgctcat tcagttcatc 2139421 cattggaacg ccgcttaaac ggtcgttcag tatatttacc agtttttcaa tatcagacag 2139481 atccattttg gtcggaaagt taatcgtttt gttttccaca tgccccgtat tggtaacgag 2139541 aatcgctacc gccatatcag gctgaatcgg aatgatttga atctgtttaa ggtaattctc 2139601 actcaacttc ggcccgagta cgatggatgt gtaattcgtc agatcggaca aaatttgcgc 2139661 tgatttttga actgtcttct ccagctcgaa aattttctct ttgaagatcg agtggatttg 2139721 gtccaggtcg cttttcgtca atttgacggg tgacagcaaa tggtcaacat agtaccgata 2139781 ccctttttct gacggaacac gtcctgagga tgaatgggtt ttttcaataa agcccaattc 2139841 ctccaagtca gccatctcgt ttcttattgt tgcagagcta aatgtgattt catctttttt 2139901 cgaaagagtt cttgatccca ccggctgtgc cgatttaata aaatcgttga ttataacctg 2139961 aaggatcagc agctgacgat ttgttaacat catcatcacc tctgttagca ctctcaataa 2140021 gcgagtgcta attctataac aaaagtatca aaccacaaga aaaatgtcaa ttataactca 2140081 cccaaaaaag cgccaaaaac ttcattgcct aataatttcc cttgatgagt caaataaacg 2140141 gcagactccg aattgtgaat cagccctttt tcagcgaggt cttttaacac gcttgggaaa 2140201 agtccatcca gggaacggcc gtatttttct gcgaatcgtt ttttgctgac accggctgtt 2140261 tttctcaaac ctaaaaacat ttcttcctca atctgttctt ctgttgtcac ttcatgtgta 2140321 tctctgtacg gaaaaccctt ttcagctatc aggtcaatgt aatgcttaac aggtccgacg 2140381 ttcactgttc gtgtgccgcc aatatatccg tgagcgccag ctccgaaacc gaaatattgt 2140441 tcgttgctcc aatacgttag attgtgctta gattccatgc ctgccttagc aaagttgctg 2140501 atttcatatt gatgaatgcc gtgagcttcc atcttgctca tcactatttc atacatttca 2140561 gcttcctgct cctgcggcgg aagatgaagc cgcccttttt gcatcaaatt ataaaatacc 2140621 gttttcggtt ctacaataag ggagtaaacg gaataatgct cagcgtccaa tgataaagca 2140681 gtgtttatgg aatgttccag atgcttgagg gtttgccccg gaagcccgaa catgagatca 2140741 agactgatat tctcaaaacc gatttcccgc gctctttcaa aagaggtgaa tacatctttt 2140801 tgcttgtgca ctcggccgat tttttctaac agatcgtctt cgaacgtttg cacaccaaag 2140861 ctaaggcgat ttacgcctgc ttcttttaat atttttaatt tctctgcgga caaatcgtcc 2140921 ggattcgctt caaccgcaaa ttccgataag tcgcttgagg gctttagcac gcggttgatc 2140981 atatccatca gctttttaag ctgttcctca gacagggagg tcggcgtgcc tcctccgata 2141041 aagattgttt tgagatcagg ctgcccggtt tttgctattg tatttatcat ttcctgttcg 2141101 agtgcgttta aatactcgtc gactggctga ctttgaataa aatatttatt gaaatcgcag 2141161 tagtggcaaa tatgctcaca aaatgggata tggatataag ctgatttcaa cggattcacc 2141221 ttctttacag aaagaagccg cagtacaaga ctgcggcggc ttctattgtt ttttcggact 2141281 gtcgtccatt ttcagaactg ccataaatgc ttcttgcggc acttcaactg agccgacctg 2141341 cttcatacgg cgctttcctt ctttttgttt ttcaagaagt ttccgtttac gcgagatgtc 2141401 ccctccgtaa catttagcca atacgttttt acgcattgct tttatggtgg agcgggccac 2141461 gattttctgg ccgattgcgg cttgtaccgg aacttcaaac tgctggcgcg gaatgagttc 2141521 tttcagtttt tcaacgatca cttttccccg ttcatatgcg taatcacgat gcacgataaa 2141581 ggaaagggca tcgatttttt caccattcag cataatgtcc attttcacaa gcttggacgg 2141641 tttgtagccg atcagttcat aatcaaagga cgcatagcct ttagtgcttg atttcagctg 2141701 atcaaaaaac tcatatacga tttccgctaa tggcatatca taaatgatgc tgacacggtt 2141761 tgcgtctaaa tactgcatat caatgaaatt gccgcgtttt ccttggcaaa gctccattac 2141821 agcgccgaca tagtcattcg gcaccatcat cgtcgctttt acgtatggct cctcaaccct 2141881 ttcgatcttt tgaggatccg gcatgttgga cgggttgtcg acaacgacct tttcgccgtc 2141941 tgtcatatac acgtcataga taacgcttgg cgctgtcgta atcaggtcga tgttgaactc 2142001 acgctcaatt cgctcctgaa tgatctccat gtgaagcatg cctaaaaatc cgcagcggaa 2142061 cccgaatcca agcgcttgcg aagtttccgc ttcatattga agggaggaat cattcagctc 2142121 aagcttttca agagcttccc ttaaatcatt atacttcgct gtatcaatcg gatacaaacc 2142181 acagtacacc atcgggttta gcttgcggta tcccggcagc gcttcttctg caggattggc 2142241 agcgctcgtt attgtatcac cgacacgtgt gtcaccaaca tttttgattg aggcagtcag 2142301 gaagcctaca tcaccgaccg tcagttcatt tgtcggagtt gctttcggcg tgaacacgcc 2142361 cacctctgtt acttcgaatt ctttgccggt tgccatcatt ttgatttttt gtcccggctt 2142421 taccgttcct tcaacgactc tgatataagc cacgacaccg cggtaggcgt cataaagcga 2142481 gtcgaagatc agcgctttga gcggcgcctc cggatctccg gtcggagctg gcaccttttc 2142541 tacgatttgt tctaaaatct cctcaatccc gataccggct tttgctgaag caagcacggc 2142601 ttctgatgcg tcaaggccga taacgtcttc tacctcttgg cgcacacgtt cgggctcggc 2142661 gctcggaagg tcgattttat tgatgaccgg aaggatttca agatcgttgt caagcgctaa 2142721 gtagacattg gcgagcgtct gcgcttcaat cccctgggct gcatccacga caagaatcgc 2142781 tccctcgcag gcagcaaggc ttcgggatac ttcatacgtg aagtcgacgt gtcccggcgt 2142841 atcgattaga tgaaagatat attcttctcc gtcttttgct ttatatttaa gctgaacaga 2142901 gtttaattta atggttatgc cccgctcacg ttcaagatcc atagaatcga gcaattgttc 2142961 tttcatttct cgttgagtga ttgccgacgt tttttctaaa atacgatccg ctaaggtcga 2143021 ttttccgtgg tcaatatggg caatgataga gaaattccgt attctcgatt gcctctctaa 2143081 acgcttttct ttatctgtca caatctatca ctcctactat taaacgcaaa atacactagc 2143141 ttagattata tcaataggat tgtaaagatt caatgtaaaa caagaaagag aaaagttccc 2143201 tatcatatct gggttgcttt tctctttcac gtacttattg attcatatcc cgtatccatt 2143261 catacattga ctgggcagta ttggttacgg tgtccgaaag cgcttttccg gcttttgaaa 2143321 acatattgaa tgtctccacc ttttccagct ctttttgttt ttctactaaa tcttttgccg 2143381 tgactgtttc tcctaggatt gaggcttctt tttcattatc ttttccgtcg gtgagcgtaa 2143441 acgccccctt cagtgaaggg tcatgatagc ctttcatact cagcatcccg tggtttgcct 2143501 gctgcatgcc gaacagaacg cctaaaaaca tgatcgtgac aagcagtaag cactttccaa 2143561 agtatgcaat caaatcaacc acctatttct tattgttttt tcgtctcccc gctcgctgcg 2143621 ttgacctttt cagcatccca gtacatttcg ctgaatacgt ccgcggccgc gttagccgca 2143681 cgctgcagct cttcgagatt attatccact ccgccaaact cgagcaaaag cgctctatcg 2143741 gttaaatcct gattgtaaac accattatcg cctggcgagc ctttggaaaa gacacctgtg 2143801 ctaagtccgg ggtatttttt ctccatcagt ttatgaagct cactcgcaat tttatagttt 2143861 tcttcgaagt ttttgctttt tttcccgacg acaaaggcta ccctggcata gcttttccct 2143921 ttaatcgttg cggttgtgtc ttttttgcgc cgagagtctc tgtggatgtc aatgatatat 2143981 tgcagatttt tgtttgaagc gagggcgtct ttcacgaccg gccttgattc atcataggac 2144041 ctggcatagt ttaagccttt tttattcaat tttgactgta tatcggtttt attcactgtg 2144101 gctccgattc cctgggattc aagcgcttgt ccgaacatat ctcctacaag cgtgacattg 2144161 gctttagaat ggcgcgccat gtcaggatcg gtctcgcctt ttaatagagg gagatatgat 2144221 tccgtattgt gcgtgtgata gataaacacg acctttttat cacctgttgt ttgtttcggc 2144281 ggatcttttt gcgcattatc tgattgcgtt tgctgttttt caatctctgc caaattcgct 2144341 tctctttctt cctccatcac cttagacggc ggcggcgatt ccgcaggcat attcgtataa 2144401 tccgttcctt gtccagctaa caaaatctcg gtatcaaatt gtgcaaatcc tggcagctcc 2144461 cgaccgagaa agctccgcgg atcttcgagg ttaatgctcg tcgccagctt taaagaaaga 2144521 cgagaaagat gaaatgagct gtctgtttga gagaggtcag aagcgaaata atggttttcc 2144581 atctgcagca aatgtgcaaa tacgtcaccc ggcaattctt cagcaatccc ataaaaagag 2144641 tcagacgacg gcctaagttc cggccggaga gacgtcagca caccggatag aacaaaaatc 2144701 acgataaggc ttacgataaa tagaaagatg gcttttaccg ctttccctcc atttaccgca 2144761 acaacaatct gtctgtttct gcgtttattt ctcattgaat ccctccagcg cttgtctagt 2144821 aattactcta tgaacaagct agaggaagta gaactgttta gtgattgtag gagcctttgt 2144881 tttcttgtga cactttttca tgaagcgctg tgtttaatcc gttcgctaaa acatttgcca 2144941 tatcgtcgat aaatgaatcg acttccttcg gtgtaaccat taagttgtgc cctaaaggcg 2145001 aaagcacctc gtgaatgagc tgccgttttt catcttcttg aagggttccg acaataccta 2145061 ggaacgattg gcgctgcttt tgatcgggaa gatcgtcttc agtgagcact ttctttttcc 2145121 caaacgtcat gcctgccgga acaagcgatc ttgatggcct gttatccttc atttctctgc 2145181 caaaatgttt taatatgtag tccaccgtgt cgctggcaat tgtcacggca tcaactactg 2145241 tcggaacacc gatagcaatc accggaacac caagcgtgtc tttgcttaaa tcttttcgtt 2145301 tattccccac tccagacccc gggtgaatgc ctgtatccga tatttgaatg gttgtgttga 2145361 ccctttccac cgcccgcgcc gccaacgcat caatggcgat gacaaaatca ggcttcgatt 2145421 gctcaatcac acctttaata atgtcacttg tttcgattcc tgttatcccc attacacccg 2145481 gtgcaaaagc actgacaggc ctgtaaccct cctgtacgtt ttccggctga agcttaaaca 2145541 agtgccttgt taccaacaga ttttctactg ccatcggtcc aagcgcatca ggtgtcacgt 2145601 tccagttgcc gagcccaacg atcaaacagc tcgcatcttt tgagatatta aggttttcaa 2145661 gaaaagctga gaattcctcc gcaaagacag cagagacctt ctcctgcatt tccgaatcat 2145721 tctccctgat tccctgtgct tcaagcgtta aatagcgccc ttcttttttt cccgaaagct 2145781 ctgcgccttc ctttgtaaca tcaactgtgc ggattttaat gccgccgtga tcacgctctt 2145841 tttcaataaa gcctttaatt tcttttgtcg gcacagcctg ctgattggcc attgcttcct 2145901 tcgtttccac tgccaaatcg gtccgtatca aatactgatt cacatccagc tcactctttt 2145961 tcatacaggg gcctccttca cattaagtac ctatattgtt gccatttgct gaataaatca 2146021 tgctaaaaag agaaccttca atgaaaaata ctttacattt atattgcaat ctaaaggtgt 2146081 gtttgataga atacaatttg ttctattgtg aagaagattt aaccttaaga cactgtgcta 2146141 caggttgtat cttaggaggt gaaacacatg ccaaacatta aatcagcgat taaacgtaca 2146201 aaaacaaaca acgaacgccg cgttcataac gcgacaatca aatctgctat gcgtactgca 2146261 atcaaacaag ttgaagcttc tgttgccaac aacgaagctg acaaagcgaa aactgctctt 2146321 actgaagcag ctaaacgtat tgataaagca gtgaaaacag gtcttgtaca caaaaatacc 2146381 gcagctcgat acaaatcaag actagcgaaa aaagtgaacg gactttctgc ataatataaa 2146441 aacgatcctc aataatgggg atcgtttttt tcatttcttt ttaacagctg taaaaggaac 2146501 agttcgagca ggagctgctt gtcctttttc ccggttttca tctcatagtc catgacggca 2146561 agctgttcaa taattaaacg gagctcctcc tctgaaaaaa gccttgcttg atccatcgcc 2146621 agctttaccc gaaatgggtg aacttttaga ttagaagcga tttgtttttg tccgtatccc 2146681 tgttccgcga agtacttcgt ctgcagaatc agccggaact gattcgaaat aagcgccata 2146741 attttgatcg gttcttcatt ttgttttagc aaatcataaa aaatttgcag actctctgtt 2146801 cgttttcggt tgacgatttt attgatcagc tcaaaaatat tttgttcaag gcttctagca 2146861 acaagcattt ttacatcatc cagcgtaatt tcttcacgat ctccaataaa cgtgcagagc 2146921 ttttgaatct cctgaaaaat cgatgacaga tgaccgttca caagcagaac caaatgctcc 2146981 gccgcttccg tgccgattgt tttctgctct gtttttgcaa ggttgacagt aaagtctgtc 2147041 gtttcctttg catttaattc cttcgcctcc atcataaacg cgtgcttctt taacgctttc 2147101 gtcagctttt ttcgctcatc aagcttttca tacggagcaa gcaggacaaa gactgtgtaa 2147161 ggcgcaggtg attgtatata tgattcaagc gcactgacgt tgtgctcaat tttttctttt 2147221 ttcttttcac ctgttaaaaa atatggattt ttcacaatga caagacgccg ctcccccata 2147281 aacggaaacg tttcagcatc tgcaatcgct tgatccagcg ggtcctcttc cagatcaaaa 2147341 acggacagat tgaaatcctt tgtctcctga tcaacgaccg tctgtctgat cctgctgacg 2147401 gtttcttgca gcagatatgt ctcttttccg tataaacaat aaaccggatg gacctctcct 2147461 tttttcaggc ttttccacac atcaaatacc attgttgtac gacttcctct ctttcatcat 2147521 ccccttctat cctaaattga gtttgcaaaa tagtaaagag gaagcctgac tgctgcttcc 2147581 ccatttatat taaacgcctg ttcgcaagcc cccgggacag cttgtaaaaa ggcgataatc 2147641 accagaacag aaaacgttac cttagcttct agatttttca aaacaattcc attatactta 2147701 agtcagtcag gagggataaa gttgaatgat tttgaaaaaa acgttcaaag caaacgaaat 2147761 gatgctgtag attcagctgt tggttttgtt gtgtccttcg gatttttcgc cttcttgttt 2147821 gtcatggcaa cggttattca cctagttggt tcataacagc gactgcccgg gctgctgatt 2147881 tctcggcagt cttttttagt tcgtctctgt tatatctgat gtatcatatg gaggatagac 2147941 agaaaaggtt ccaactctgt ttttgtatct atattggatc gttccgtttt gatctgttcg 2148001 cagcacgcgg atagaatgtc tctgtaatag ttgcagaact ttttgatgag gatgatggta 2148061 ccgattgttt ttcccggctg agataatggc cgttttcggc tgaagctgtt ggatgaattc 2148121 ttcaccggta gagcctttgc tcccatggtg ccccaccttt aacacatctg cttttatatt 2148181 cggaaacacg ttcatcacct cttgttcccc ttctttctcc agatcacccg tcaagatcca 2148241 gctcataccg cccgtctcca tccacagaac gagagatgaa ttatttttgc ttgccggatc 2148301 aggtgcttcc ggtgacagta catggaactg caaatccttt atttgcaaca catcgcctcg 2148361 cttcacctct tcaattgcca ctccctcttc cctggctgcc tgcagcactt tctcatcttt 2148421 aggttcagaa acgaaccctt tcggaatcac gaggcgcttt actttatgat gcttcagcag 2148481 aatctccgcc tctccgatat gatcttggtc agcgtgcgtc agaattaaag cgtcaagctg 2148541 cttgattccc ttagcagtta aaaacggaat cagcaccttt tcccccagtg aaaacggatg 2148601 ctgtttttcg cgccaaggct ctgacgagta agacaaagtg ccgccggtat caattaagac 2148661 acgaccccgc tgatgcggag cacctacaaa catgctgtca ccctgtccaa tatctatcat 2148721 atccacttct ccttcggaac taagacacgg atatataaag agcagaaaca tcaccgtgca 2148781 gcaaatgcct ccggttacca tcaactgcga caaggagcgt ttttcaatcg ccataagcaa 2148841 taggatgatc gtgactgtga ataaaaaaag caaaacaggt gcaggatgtg cgatcataat 2148901 cgtgaacaca tcaacatctg caatgtttgt gattaaccta ttgatccagc ttatcaataa 2148961 atcaaaccag ctgaaaaaca atctcccaaa cgaagcggaa agacttaata gaagaacacc 2149021 tgctacagct cccggcaaaa tacagaaggt ataaaatggt accatcaaca tattcatcgg 2149081 tacgctgatg atagaaaact gatgaaaatg atataggaga atcggaagcg agcccagctg 2149141 agcgatgagt gatacaattg tcagctgccc caaggaggtt ttaacctgct gaaaaataga 2149201 agaggataga attaaagaaa aactgacggc gaacgatagc tgaaaaccgg cttcaaagag 2149261 atgataagga ttgaagagca gaaggacgat gtacgaaagg caaattgcag ttgcagagcg 2149321 gacacgccat ttgacaagac ttccagctaa gtaaacaccc gacatgagag cggcgcgtag 2149381 cactgaagga gcagcgccgg tcaacatcac atagagcggc agaaataaca gcaacagaat 2149441 tgacgccttt tctctagtta taccaaggcg gatcatgata taaaacaaac ctgctgtcaa 2149501 aatccccacg tggagtcctg atattgccaa gagatggaca acaccaagct tttgatacgc 2149561 ggtaagcact tcatcctcca cgtaaaatct gtcaccaact gtaagtgcct gtacaatccc 2149621 tgtcgaatca ggaggcagaa ggctgtttgt gaatgatatg atatgttttc tcaagctgag 2149681 caccttgtac ttgaaatttt caggttcgct gcagttttgg atagacgtga cagagtagtt 2149741 ccaatgaata tgctgccgat aaagatactc gttataatca aatgcacccg gcacagttgc 2149801 gtgattcggt tcttccaatg taccagtcaa ctcacatgac attcctggtt ctatgtataa 2149861 cagctgttct ttttcaccag cagactgaat gcgatacgca gcagcccatt tttccttatc 2149921 aggtgtctca accatcatag acatacggtc gccgtcaatt ttgggaatag tgtcaatcac 2149981 tgccttgaat tgataggttc cctgccgata ggaagagaca ttctgagaat ctgtgactgc 2150041 atacagtaca aaaaacaata taaaagagaa gaaacaaaca ataataagaa aagcgtgcct 2150101 cgttttgatt aaaatgatga ggagaaagag gatgaaaaga aaaatagcgg ggaaataagc 2150161 ggcggcagta attccagccg ttgccgaagc tgccgccata ggcaataata agcgcgaatt 2150221 acgcattcat cacacgtagc tcgtgaaaag tgtattcgcc tgttcatgta tctttttcaa 2150281 ttcttcctcc gctaaaccgg catcagccaa tttccctatt agacccgcta caaatgaaag 2150341 cttttctctg tttttcagat caacgatcat ttcatcgagt tcaacctgtt caacagttac 2150401 acccgcctgt tcaaataatt cctgcgcata cggatgtgtt ttgtaatcct cagcataata 2150461 aaccgttttg ataccagctt gaataataga tttgcagcat tgaatgcacg gataatgcgt 2150521 cacataaatc tcggctccat cagtcggcac cccaaactta gagcattgaa gaatcgcatt 2150581 catttcagcg tgaatggttc ttgcgcaatg atcatctatc attaagcatc cttcatctgc 2150641 acaatgtacg ccgcccgcga ttgacccatt gtagcctcct gctatcatgc gtttgtctct 2150701 gactatagta gcgccgacag ataatctcgg acatgtgctg cgcagcgcca ataaatggct 2150761 ttgagccata aagtattgat tccatgaaat tcgttccacg ttgttccctc caaatgttgt 2150821 gttgcctgac ctttagttta cctatcataa tgcatgaccg tcaaatcact ttactgtaat 2150881 ggaagacttt attttctcaa atgacttttc acctattcct gaaaccttag tgatatcttc 2150941 aattgtttgg aaacgaccgt tttcctcccg gtatgcaata atagcttcag ctttggatgg 2151001 ccccacccct gagatgcctt gtaactcctc taaggttgct gtattgatat tcaccagcgc 2151061 tcccttccct ccatcgcttt ggacagaccc tccgccacct tgctgcactg ctgtttcctc 2151121 tccctttttc gggatgtaca ccactgtccc gtcctgcaga atctccgcca aatttacttg 2151181 cgcttcgtct gcttgttcac tggtcccgcc cgctttctca attgcctgag atactctgtc 2151241 ccctgttcgc atttcataaa cgccaggatg ctgaacagca cctttgatgt ctatcacaat 2151301 tgtttcgttt gactcgtcgt tgtttgcttc ctgctttacc actgtatttt ctgtctctgt 2151361 tggtacagct tgcttcaccg gctctttatt tttccctgtg gccagaaaga tcataatcgc 2151421 tgtgaaaaca gccgcagaag ccgctaaaat aattgctttc ttatgctgat tcaaccaatt 2151481 catcgtgcat gttccccgct ttcgtcatat tttattttca taacacatat ggtttagagg 2151541 ataatagctc aaaggagggg aaaccattga agataggctt tatcggcaca ggaaatatgg 2151601 gtacgatcct tatcgaatca tttattgaat caaaagcggc cgatccctca aacatgacaa 2151661 tcacaaaccg cacaattgaa aaagcgttgc acataaaaaa ccgctacaac agcataaacg 2151721 ttaccgaaag tctcgaaaag ctcgtttctg aaaacgagat gatttttatt tgtgttaagc 2151781 cgcttgatat atatccttta ctggcaagag cgttacctta tttaagaaaa gatcatattc 2151841 tcatttcaat tacaagcccc gttcaaaccg aacagctcga acaatatgtg ccgtgtcaag 2151901 tggcgcgagt gatcccaagt attacgaaca gagcgctggc aggtgtttct ctcgtcactt 2151961 tcggcacaag ctgcggcgaa tctgcaaaag cgaaaatcaa tgagctgatg cagcatatct 2152021 ctcatccgct gcaaattgaa agtgacatca cgagggttgc atcagacatc gtaagctgcg 2152081 gccccgcttt tatgagctat ctgattcagc ggtttataga tgcagctgtt tcggaaacat 2152141 cagtgtctaa acaggacgcg attttgatgt gtaaggaaat gcttgtcgga atgggaaaac 2152201 tgttagaaac cgaattgtat accctgcctg cattacagga aaaggtttgc gttaaaggcg 2152261 gtgtaacagg agaaggcatt aaagcgctgg aaagcggtgt gcaggatatg tttcaccggg 2152321 tatttcaaaa tactcatatg aagtacgagg aggatatttc cgcagtgaaa aagcagtttc 2152381 atgtgtagac gagtatgtca tacgttcgtc tgtactgcaa aagcataaaa aagcatttta 2152441 aaaaaccatc gttttaggaa acgatggttt ttgatttctg cgccttgaaa aagaggcgtt 2152501 ctgattgtgc tgatggctcg gtatccgtaa aatcagctgt cacgcgatgg agctgaaagc 2152561 cgcagttctt aagcatttct tcgtattctt ccaccgggaa cgttctttgc tcgtgtgtct 2152621 catcaaaacg atcatacgct tctccgttcc acacaaaaaa cgacatatca tgaatgacag 2152681 aaagctcgtc acttccggca aagctctgcc aaatatagct gatatcttcg tcctggtcag 2152741 caaatgtgct atccggaaag acttccgcaa ttttaaaaga tgaatgaaca tcaaacagca 2152801 ggatgccttc aggctttaat acccgaaaaa cacttttaaa ggtttcgatc acatcatttt 2152861 ttgtttttaa ataatttaat gagtcacagc atatcacaac agcgtcaaat tgaccgtcaa 2152921 agccggtaat ctctctcata tcctgctgaa gaaataaaat aggctggcta ctcgatacct 2152981 tttgctgggc gaaagaaagc atctcttcgc tgagatcgat gcctgtaacc tcgaagcctt 2153041 tttcggcaag ccggatggag atttcccccg tgccgcatgc cagatcgaga atacggcctt 2153101 tttccgggag agatgcttca atccattttg tccattgatc gtaaggcgcg tgtgacatta 2153161 gctcgtcata cacgcttgca aagccttgat aaatcattga ttcattccaa agtcaagatc 2153221 tgcgagcgga gcgtctcccc acagcttttc aaggttgtag tagcttcttt catccttgtg 2153281 gaagacatgg acaactacat cgcctagatc aacgagaacc catcttgctt catcaaagcc 2153341 ttccatcttt ttgacttgaa tgccgttttc atcagcttga tccttgattt cacgggcaat 2153401 cgcctgtacc tgtttatctg aatttccgtg gcagatcaga aaataatcag caaccagaga 2153461 aataccttcc atatccagtg ctaaaatatc ctctgcccgt ttatcatcgc aagccgcagc 2153521 tgcgatcttt aaaatggact tttggttcat tcacaaattc ctcctgttca gctgccagac 2153581 acaagccagt tatacgttaa aaatgtgtct ggaaaaaccg gttgattttt tttcataaga 2153641 aaaaccattg tatttttaat ggactgaatc agcgcttgat tcaaatctgt ctcagcaagc 2153701 ttacgcacct catcgacacc gggaaatgcc cggtttggct caatgtaatc ggcaacgtaa 2153761 atgacttttt ctaaaagtgt catgccgggg cggcctgagg tatgatacct aatggcgtca 2153821 agaatgtctt catcttgaac ccctgcctct ctttggacca aataagcgcc gaccggagcg 2153881 tgccagagct ccggattatg atccaataaa tgcgcaggca ttttttcacg cgcaataatt 2153941 tgtttcattt cttctttcgg gcggaatttg gcgtaatcat gaaagattgc cgctatttcc 2154001 gcttttttag aatcggctcc aaaacgctcc gcaagttcga tcgccgtgtt catcacgcca 2154061 accgtatgga tatatcggtg ttcggtcaat tgctgcttca cgcatgcaag tgcctcctca 2154121 cgattcatat aaaccattct cctctacata cttcttcact ttatcaggga ttaagtagtc 2154181 agtgggcttc ttgcttttaa accgttccct tatcatagtt gatgatacct caaattccgg 2154241 aacgtctgca aagagaagcg gataaggggt ttcaacatga aaaccggggc gctttactcc 2154301 aataaattga atgaggttca gcagctcgtc cagcttatac catttcggca aatattcaat 2154361 catatcagcg ccgataataa agaacagctg atcatttgga taacgctgct tcagtaaaga 2154421 aacggtatca aaggtatatg atggcccttc tctttccatt tcaacaagct ccagcttaaa 2154481 ggacggatta gattgaattg caagctttag catttccacg cgatgaaagc tgtcggtata 2154541 gtcttcgttc tgtttatgcg gcggaatttg attaggcata aaccaaattt catcaagccc 2154601 cgcctggtac agcacctcat tcgccattaa gaggtgacca ttatgcggag ggtcaaacgt 2154661 gcctccgaaa attccgattt tcttcatttc aaccaccttt aaggaagctc gatttgttta 2154721 ttttcctttg attccttata taacacaatc gtattgccga ttgtctgcac caattgagag 2154781 cggcttcctt ttacaagagc ttccgctaca tcgtttttat cctcttcgca attctgaagc 2154841 acgctgactt taatcagctc tctcgcttca agcgcctcag caatttgttt aatcatgttg 2154901 tcgtttactc cgcctttacc tacttgaaaa atcggcgtta aatgatgcgc ttttgaacgc 2154961 aaaaaacgtt tttgtttacc tgttaacatt ctgttcctcc taattttcct attacaatag 2155021 atctcatttt ttcaatatta ggctcttgtc cagtccacaa ttggaaagac aatgctgcct 2155081 gttcaacaaa catgcccaca ccatcgagtg ttttcaagcc tttttggctt gcttctttta 2155141 aaagtgccgt ctgtattgga ttatacacga tatcacatac gacggcactg ctcgcggcac 2155201 gctgtaatga aagcggcaca tcgtccacgt tcggatacat gcccacagac gttgtatgga 2155261 tgataacatc atactgctca agacgttctt ctgcttcttt tatgcttaat acttctttat 2155321 tgtgaaacga gggagtagct tctgtaagcc gctttgcttt ttctaacgtc cggttgcaaa 2155381 tgtcaaattt tttcggggta tttcggacaa ttgttgtaaa aatggctctc gccgctccgc 2155441 cagcgccgat cattaagaat gacagttcag agatgggctt gtctaatacc ttcattaatg 2155501 acttcacgaa gccttcccca tcggtattgt atccgacaag cttatctccc tctcttctga 2155561 ccgtgtttac ggcaccgagc acttttgcac tctcatcaat atgatccaaa taatccataa 2155621 tggaaacctt gtgcggaaca gtcacattga ttccttgtac gcctagagct cttattcctt 2155681 ttaccgcatc ctccagatca ttctcttcta ccttgaaggc atgataatgt ccgtcaagcc 2155741 cgaggtcttt caatgatgcg ttatgaatat caggtgacat agaatggcca ataggatttc 2155801 cgataacccc gtacagcttt ttcatacacc tctccccttt tcttaaatta atgaacgccg 2155861 aacaaataca tgaacgcctt ttggcgcgta tgcagttacc tttttatcag cgtcatggac 2155921 agtaacccag cctaacccag agaaaacgat atctgtcttt ttgtctttta tcgtaaacgt 2155981 atgggcgacc aattcaggaa actcatccat ttcatcttta cccggaggtg tgagcaattc 2156041 ccctgcatgc ttttcataaa gcgcgtctgc attttcaagt tttgttctat gaatcatcag 2156101 ctcattcggc atatagcaaa taaaaggaga tctttcccca gacacataat caaaccttgc 2156161 aagtccgcca aaatacagtg tttgctgatc attaagctgg aatgtgcgag gcttcagctc 2156221 ctttttagga gataatattt tcaggtcctt tttattgaca taatgcgcca tttgatggtt 2156281 gttgataatt cccggtgtat cataaagcga tgaaccgtca tccagcggga tttcaatcgc 2156341 atcaagggtt gtgccaggaa attgggatgt tgtaataata tcttcttcac ctgacacttc 2156401 tttaataatc cggttaataa aggttgactt tcctacattt gtacatccga caacatagac 2156461 gtcttttccg ttgcggtaat gctcaatcgc gtcaattact tctctgattc cctggccgcg 2156521 acccgcactg accaaaaata cgtcaaccgg ttttaagcca agctctttcg cttcacgctt 2156581 catccattgg atcagacgct ctcttttcag tgacttaggc aaaatatccg ctttattgcc 2156641 aactaataag atagggtttc cccccaccaa gcgctgcagc ccattaatcc agctgccgtt 2156701 aaaatcaaaa atatcaacaa tttttacgac cagagagtcc gtttctccaa taccgtgaag 2156761 aatgttcaaa aaatcatcat cagttaagga gacatcttgt atttcattat agtttttcag 2156821 tctgaagcaa cgctggcaaa tcacattttc tttcgtaagc gatgcaggcg gcgcgtaccc 2156881 caaacctgtt ttgtcctcgg tttggatcgt aactccgcac ccgatacaaa caaccttttc 2156941 catttcttac tcctcccact gaatgtgccc ttttcgtttg agagcactca gtattctgcg 2157001 ttcgacctgg cggttaaagc gcgtaatgaa tccgtcagag gaagcgactg gcacgaccaa 2157061 aatcgtatgg tagccgtttc ggtttccccc gagtacatcg gtcagcagct ggtctccgat 2157121 gacaacgcag tcctcttttt tcagctccat attgcgcacc gctctattaa aggctttacc 2157181 catcggtttt cttgctttat agatgaatgg gattccaagc ggttctgaga aaagtttcac 2157241 tcttctttcg ttattattag agacaattgt cactttaatg ccgtgttcct tcatttcttc 2157301 aaaccactcg atcaatcgcg gcgtcgcgtt cggcctgtcc cattcaacaa gcgtattatc 2157361 caggtcagta ataattcctt ttacatttcg ttcctttaat ttctcaggtg taatatgaaa 2157421 aatatttttt acaaactcgt caggtaaaaa aaactttttt aacaaaaccc gcacccttcc 2157481 ctttttcttt ctttcaaaat gattgtcgaa aaaaatcgaa cttgcgccta aagaaaaact 2157541 gagcaaaaaa atttcgacaa aaattgggtt tcttcaccag gtgtggataa atttacacac 2157601 actatccact cttattacat cactctttag acaaattata aacacgatac tcacaagtta 2157661 tccacttttt ggtgtggata acagaacgat tgttcttata tgcatttcat ggtagattaa 2157721 agataacttc aacctcagat gaatgcaact tatcattgta tgcgttaaaa tcatgaatga 2157781 ttccaacttt taaggaggtg cctctcccat taattgggtt cctagcatga gaaaactgtc 2157841 tgatgaatta ctaatagaat cttatttcaa agccaccgaa atgaatttaa accgtgactt 2157901 tattgagtta attgaaaacg aaataaaaag aagatcgctc ggacatatta tttccgtatc 2157961 ttcttaatag gaatttgtct attttttccg ggcgtatttc ctttttttac tcagatgact 2158021 gatattatat cactttggct gcgcgcttta ctactatttt cagcaaaaaa cacccctaaa 2158081 aagaggtgtt ttaaagggcc ggttattatg ctaaccagta tatgccgccc acaacaagga 2158141 gaacaacaac taaaacaaca ataaaagcgt atccatatgc tctgcctgcg ccatacatgt 2158201 gaagcgcctc cttaataagg ttttataaca gcctatgtag gagaaataaa tcggactagg 2158261 cggttgtccg gctcaacgct gcaggatctg ccccgcgaac taatttatta atgttcaaca 2158321 acagaatttc gtctattggc aataaagaat ccacaaatca ttgcaagaat ggccatcgcc 2158381 caccagaacg ttgagatcgc ctgatcatga tcgatgataa tcaaacgaat gacagctgtg 2158441 atgccaatat aaatgaagta gcgaagcgga aaatgaaagt ctgatttgaa gtatttgata 2158501 atcaaagcaa tgaactcaaa gtacatgaag aatataagca gttctccaag catctcataa 2158561 tagctgtcca ctttgttgaa cagtgacttg tatacgaata gcacaatgta ccaagtctcg 2158621 ctgatcagaa gtgcgcttaa ggctaacgcc agaaagaaca gacagacgtt gagaagcgct 2158681 tgtaacaggt aaggcacctt tttgaatttg ttagaaaatc tcatcatgtt gtctcctatt 2158741 tcaatatatt cgtggttttt attctcagcc tacatcttgg tgttccaaaa tcgtagcaca 2158801 atgtagtact tagaattctt ttgtatactg tgaaactgtc cctgcatgcg ggacatcatt 2158861 cgcgcaatgc ttctttcacc gagtccgttg ctttccggtg ttatatctgc aagtttaatc 2158921 gtattgctaa catggatctc aaatatctct tgatccgata caaacgtgat actgattttt 2158981 tcttccggat ctgcgtattt caataagttt gacatcacat tatcaaatac acgaccaagc 2159041 tcctccaaat tcacgttaat ataggtttcc ggcagctcgc ctgaaatatg gacccgaaaa 2159101 tgctcctgat gaaggatagc aatctgatct gatattagat cgtagatcac ttctttcact 2159161 gcaacggtct ccagatcggc ctcatattcc ttgttcagca ggaaatacgc aaacagattg 2159221 tcagacaagc tttttaattg cagtgcttta ccataagcat tggctacata ccgatctttg 2159281 ctggcacccg cttcgcctcc ctcttttttg gcaaactcca gattcatgat cagcgacgtc 2159341 agcggtgtgc gcatatcgtg cgacatttcg gtaaccaggc tgcggctctc agcttgcaat 2159401 tcctcgatag ctttaagttt atccaggaaa gctttccgca gatcctcaat gctctttgca 2159461 atcatcgcta attcatcatg cccttttatc gtcatctcgt agtccagttc gcccccttca 2159521 agaatatgaa tctcttgatg aatcgtttta aggtagcgaa gactttggcg aattccgaag 2159581 agaacaatga ttaaaaagat gagggttgcc ccgagcaaat ccaatgcaaa ggccagatca 2159641 taatatcggg aagagtagaa accgtcgata atgactcgtc cttcaccatc gctaaacttg 2159701 acaggatgtg aatgattttg agcgtactga gtcagctttt cctttccata atccgattcg 2159761 gaataaatag aatcatattg cagctcctga tccttgaata tggtgaggtt aatgtaattt 2159821 tcttttttga cccactcgcc aaacgctttt ctatctgatg tagacaactc attttctgaa 2159881 acgtacttgc tgaatttttg aatgtatctt gctgactcct cgtgataata ctcttccgaa 2159941 ctcagatatc cctcgatcag atcatctgtg atcttttgca acgtcagaaa gatcacacca 2160001 ctcacaatcg cagcaaccat tatcagcaaa gccagttttt tggttagcgt aaatttaaga 2160061 tgcgccaaat cgatatcctc ttccccattc agtttttata taaaccggac gtgccggatc 2160121 atcctcaatt ttggagcgca gcttccgtat atgcaccatc accgtattgt tggaacagta 2160181 aaagtaaggc tgtccccaca cactctcata tatattttgg gcagaaaata ttttgttgcg 2160241 tttgttcatc agaagtttca ggatacgata ctccagatct gacaacttga tttgcttctc 2160301 ctctttccac acctcattaa attcttcgct cactcttagt ttgcccccga taagaaatgt 2160361 ttcttcctgt tccttctttt cctgatagat agtatatctg cgtaattgag caatcactct 2160421 agcgtgaagt tcctcttccg agaatggttt agtcatataa tcatcgccgc cggcgagtaa 2160481 tccctcagtt ttatcgagtg tactcgatct ggccgtcaga aacagaatcg ggacgttaga 2160541 ggatttcctg atgtgctgac atgtttcaat tcccgaaatg cctggcatca taatatccaa 2160601 aataaccaaa tcaagcgagt cattcacaag ttgcaatgct cgctttccat ccttggctct 2160661 tagcacctcg taacctgcac gtgtaaggga ttcctccaaa agatcaccaa tatcctcatc 2160721 atcctctacg actaatattc gataggccat gtctctctca cctcatgatt cttgttgtta 2160781 tttctcgtgt gtccttacta tatatcgttc atagtaataa gtacgttata agatactacg 2160841 taaatcttaa caatttatga aagctgatgc tcgccacaaa tttgtcacat tttctaaaaa 2160901 aaatgatgac tcttcataaa ttgttaagat tcggtcttta tatttatcca ttgtaaggct 2160961 caagtttttc agatccgcac tacacattgc cgtgataaat gggaaaggag tattgatatg 2161021 attgtacaaa aagaaggacg cgggcaaccg gtgagtctgc gggaacgggt tcattttctg 2161081 gacatcgtac gaggatttgc cttgcttggc attattattg tcaattattt tctgatcgta 2161141 gattcagtaa agggattcga aatggcctcc gatgacgtac tgcataagct ggtttcctgg 2161201 tttgccgaag ggaaattcgt tacgttattc tccttcctgt tcggagtcgg gtttatgatc 2161261 tttatggatc gagccgcgca gaaggtagag agtcccaaca agctgtttgc ccgcaggtta 2161321 tctatcctgt tgggatttgg cattttgcac atcacatttg tttgggtcgg tgacatattg 2161381 gccttttacg ccgtaagtgg cttcctgtta ctcgccttct ataaacgcac ggccaaaacg 2161441 gtgcttagat ggattatcgc acttatcgtg tttcaattcc tgactcctgt tttcacaatg 2161501 ttgtacaatg tcatcaatac tgcagggtca aaaaacccga atttttcaga gtttactttg 2161561 tttagccaca gcagccttac ctacatggaa tccatcagca ctcggtggac agatatggtc 2161621 acgatggctg ccggctcttt ctctatgatc tattccatgt ttctcatgtt tctgctgggc 2161681 gtgtactttg ttaagatgga atttttcaaa gacatggaag cgaaaaagcc tatatggaag 2161741 cgtatctgga tcattagcac aatcgctttt ctaataacac aaagcagtat attactagac 2161801 atgtttaatc tttctgagaa tatgctgtgg aaggacattt cctctgtctt gggtcaaaat 2161861 ggcggcttaa ccggaagtat gttttatatg agcacttttg caatgctgtt tctatacctt 2161921 cctcagctgc gaggccctat gatgatattc accaaagtcg gacggatgtc attgacctgt 2161981 tatctgcttc actctatcat tggaacagtt ctgttcctca ggtacggatt cgggcttgcg 2162041 gatcatattc aatccgccgg cacgttcatg ttcagtctgg ccgtgtactt cgttcttatg 2162101 agctttagta cattgtggtt gaaacggttt aggtacggtc cgatggaatt agtatggcgc 2162161 aagctgacgt acggcaaagt aaacgggagt cccaaagcaa ctccgctgca ttcggaaaaa 2162221 tctattcaga aataaccccc ttgcacagat tgcatgactt caaattagtg ttgttgaatg 2162281 aagcgggcat taaacggaca gatttgatat atggactagt tatttttata tcatttaggc 2162341 ttctttgggc taataaatcc accagagttt actcaatgtg cattgctcat gatcgaatct 2162401 aaattgaatc ttttacgcat gttcatagtc aaaggcgcct cattcgacta tttttgtaac 2162461 ttttcgcagg aaaaattcga gaatgatgac aaatcccgca tacgacactt aatacggtag 2162521 tgaacaatag taaattaggg ttacatgcag cttgttttcc aatgaaacaa agaaaaagaa 2162581 tcatacaaaa agacaggaga aagcttttga agtattttaa cgccaaattt accgcggaag 2162641 aaagagcgat ggaatcactt ttttgtgaaa aggcctcgca gagcagctcg aatgttttac 2162701 tgaacgactg aactctatat tttagcaact gagggagtga acaatcatga aaactaaaaa 2162761 tgaaccaaaa gttattctgg aactagcaaa ggaatctgat ctgccagaat tccaaaaaaa 2162821 attacaagaa gcctttgcga tcgccgtgat tgaaacgttc ggtgattgcg aagatgggcc 2162881 gattccatcg gacaatgatg ttcaggagtc tttcaatgct cccggagcag tggtatatca 2162941 tattcttcag gatggtaaga atgtcggtgg tgcagtagta cgtatcaaca gccaaacaaa 2163001 tcataattcg ctagatttat tctatgtatc tccagaatat cacagccaag ggattggtct 2163061 ttctgcttgg aaagccattg aagcacagta tccggatact gtgctttggg aaaccgtgac 2163121 accttatttc gaaaagcgaa atatcaactt ctatgtgaat aagtgtggat ttcatatcgt 2163181 agagttctac aatgaacatc actctaatcc gcatatgcat cgcaatggac gtgaagatga 2163241 caagccccta ctgaatgatg atgacttttt cagatttgta aagattatga aaaaaaagga 2163301 ctaaacaatt gaacacggcg agatgccgca gagagttgct ggtaactttt ttatatttca 2163361 ttatcagagg aaggtaataa tgatgtttaa aaggtgtttt gatccctgtc tcataaacag 2163421 gggtcaaaac acctttgaat catcggtttc ttttctgaca tataccacgc ccactagtcc 2163481 ctcaacatag taaaaacata tcatgagtta caaaagcttt tattcaaagc atatgtttat 2163541 tttatttata cttattttca tcatttttca gaattctgga cacaaatcgg gtacctatta 2163601 gaggccaagg aactctacat ttcattaaga aatacgtact cattgccctg ctttaattaa 2163661 ttttaagccc tcgcactatg cccccccctg aattaagtat ttgatgtaac tttgaaatta 2163721 agtttatgaa aatctgtcac aaacccttat ttcataacac atcatttgtt tcagcttccc 2163781 tcgcgaatac cggattaatg ctcggcttta agatagtcaa ccaatctctc cgcactgttc 2163841 ttaacatctt cttttgaaag atgaagtgtc ccatattgtg taaacgcagg aagaaaacgc 2163901 attcctatat agttagcagt gacttgaaac ggtctgataa gctcgctgat cgtgatatta 2163961 tattctccgc ctgcttgata atcagattcc tgtgcgccta aggagatagc taagagtagt 2164021 tcttttccat gcaatttagt tcctccagtt ccataagccc agccatgtgt taacacatca 2164081 tcttcccatt gtttgagtaa cgcgggactg ctgtaccaat acattgggaa ctgaaaaacg 2164141 atacgctcat gatctaacag gagctgctgc tctttttcta catcaatgat aaaattaggg 2164201 tattcaccgt acaggtcatg aaccgtaatg tctttctctt gctttaaacg attcatccag 2164261 gttttgttga caacagacgt ttccaaatta ggatgtataa cgataactaa tgttttcatt 2164321 agactgatta tcctttcttt gccaattagt tattattttt tacgataatg aattgattct 2164381 aattttaaaa tagcaacttt atttacacct attttatcct ttttcatgaa ttcagggcaa 2164441 ctaattgggc accaaaatca atgatgactt aagacattgt tttgtagaaa tccgatatac 2164501 agaataatcc attatttaga aaatttctac cttttccctc aatccgagct cgctcttcat 2164561 gcggatggcc tattttaaag gaataactga ctatgttcat cagttattcc tttaaaatac 2164621 gaaagtctac gatatttcca tatcgatccg cttcaatgtg acagcacccc tcaagcagct 2164681 gttttaattt tccacgtccg cgttgtaccc ttgattttgc tccggagtaa gaaatgccga 2164741 gcttttcact caactctttt tgtgataacc cctggaaatc agttaactcg agcgcctctc 2164801 gatacttttc aggcaaccgt ttgatggtcg atcgaataca cacagttgct tccttggtga 2164861 aattttcttc ctctgcactg tcattaaaat gtagaacatc aggcaatatt tcgcttgttt 2164921 tttttgtacg gtaaaaatca ataatcgtat ttctagtgat ccgataaatc cagctgtcga 2164981 tcttttgttc atcgatcaga tttgggagat gcacttgtat tttcataaat acgatttgca 2165041 agaggtcatc aacgatagat tgatcgttaa ccctatgtga aatatatgtt tttaacggct 2165101 gatgaaattg atcccataga tcctctatat tcatttgaaa aaacctccta taattttgcg 2165161 tctgctttac atttgcttcg tctttttaat cgtaacaaag agcaaacaat tgttgaatca 2165221 attgtattgc agctgttgcc aaaaataatg ataaaggaga ggtttgttgt ggagtatacc 2165281 tatttaggga gaacaggatt gcgggtgagc cgtttatgtt taggcacgat gaattttgga 2165341 gttgatacag acgaaaagac tgcgttccgt atcatggatg aagcacttga taacggcatt 2165401 caattttttg atactgccaa tatttacggc tggggcaaaa acgcaggatt gacagagagc 2165461 atcattggaa aatggtttgc acaaggagga cagcgccgcg agaaagttgt tctggcgaca 2165521 aaagtatatg aaccgatttc tgatccgaat gacggaccaa atgatatgag gggcttgtct 2165581 ctatacaaaa tcagacgtca tctggaagga tcactgaagc ggcttcagac agatcatatc 2165641 gaattgtacc aaatgcatca tatcgatagg cggacaccgt gggatgagat atgggaagct 2165701 tttgagactc aggttcgctc cggcaaagta gactatattg gatccagtaa ttttgcaggc 2165761 tggcatttag ttaaagcgca agctgaagct gaaaaacggc gattcatggg actcgtcact 2165821 gaacagcata agtatagttt attagaacga acagctgaaa tggaagtgct gccggctgca 2165881 cgggatcttg gtttaggagt agtggcgtgg agtccccttg caggagggct tcttggcggg 2165941 aaggcattga aaagcaatgc cggaactcgt acagcaaaaa gagcagattt aattgaaaaa 2166001 catcgtttgc aactcgagaa attttcagat ttatgcaaag aactaggaga aaaagaagca 2166061 aatgtggctt tggcatgggt gctggcaaat ccagttttaa ctgcgccgat catcggacca 2166121 cgaacggttg agcagctgcg tgatacgata aaagccgttg aaatcagtct ggataaggag 2166181 attctccgca tgttaaatga tatctttccc ggacctggag gagagacacc tgaggcatac 2166241 gcctggtgat acattcatta ctcaatactg acatttttct taaatattta tactgaacta 2166301 tcatattaag aaagacaaga gcatgtttgt ctcttgtctt ttccacatcg tgctgaaaat 2166361 gctggctaaa catcgacaaa aatgctgccg cttaaaaaag aaccctaaac aatagagtaa 2166421 ctggaaagac aactggcttg atcagcttgg gacccctttc agctgtattt aaatcaatca 2166481 aactaatgat tcattggcag tctaaatatt attattgttt ctttacaaaa tagtaatagc 2166541 ccctgtaatg attgctaaca acgtaataac taatgatgta attacagccc acttaacggc 2166601 aaacctttga aatgacccca agtccatttt aagcatgctt actagcaata ctgttgacgc 2166661 aaccaatgga ctcatcagat gaaccggctg ccccattata gaagcccttg caatttctac 2166721 tggttctata ccatatgctg aggcagcttc tgcaaagata ggtaccatac caaagtaata 2166781 tgcatcattt gataaaacaa aagtaaacgg aatactagtg agtgctacaa taacggggaa 2166841 aaaccctccc attgatgagg ggatgatgga tattaatgat cctgctatgg catccaccat 2166901 ctttgtcccg gataatatac cagcaaatac tcctgctgaa aataccaata ataccacggt 2166961 tatggcatta ccagaatgct cggcgattcg ctccttctgc atttttacat tcggataatt 2167021 tatagtaagg gcaagaacaa aaccaattaa aaataaaact gacggatgct tagttccaag 2167081 cacaataaac accatgatac ttataacgag gaataaatta agatatatta agcgtggcct 2167141 tttcaattgt tcgctctcca aagtagcagc catataagat tgagagctgt cctttgttat 2167201 atgtctaggc tctaattgaa cgatgcctat tcgattcctc tctttccttc ccattagaaa 2167261 agccagaaat atcacacaag caatacctcc aagcatggtc ggaagtaatg gcacaaagaa 2167321 atctgaagga tccaaaccca gcactgaaat cgctcttgta gctggtccgc cccatggagt 2167381 cattccgcta acgatactca acgacagcat tgctaatgtc gccataacca tgggattcat 2167441 accaattctt ttatacaaag gtaacattgc tgagactgtt atcatatagg ttgttgtacc 2167501 gtccccatct aaagcgataa gcattgccaa gacggcagac cctatcgcta ttttcacagg 2167561 gtctcccttt actatagata aaattttttc tattagcgga tcaaataaac ctgcatcaat 2167621 taaaattccg aaaaaaagaa tagcaaacaa tagcaatgcc gctgaacttg caactgtttg 2167681 aattccttct aaaatcatgt cgccaatacc cttaccaaaa cctccaataa gagcaaaaac 2167741 aatgggagtg atggtcaagg caacaatagg cgagactttc tttgtcatta ttaatattgt 2167801 aaaaacagtt accatcgaaa aacctaaaat agtaagcata ttacacctcc aagaatgcgc 2167861 tttcaaatga cttttgatta acatatctta tacggtgtaa taagttaaat aaatattttt 2167921 ttactgtgtt tcaaaaaaaa ttctatcata actttaaatg gttaccattt gttcaccctt 2167981 taaaaaatca atgaatgctt taacgagttt gattcctaat gatttttgat cgtacattag 2168041 ccaagtatct ctcattagag gcttaccctt agcattatac agttccattg tgtacaaatg 2168101 atcagattcc tgcaggcaaa tttctggtgc tatggagtaa ccaagaccat gctttaccat 2168161 ctctttgcaa gtctcttgtc gatccacttc cattgcaata atgggggctt gttttagatt 2168221 cgtatgcatc caatcttcta taatcgtttt taaagaagca tccgttttat atttgataaa 2168281 aggtaaaaaa ggaagttgct ctatcgttat tggttttttt gagatgatat gtaatttttc 2168341 ccgtgtcagc cgttcctcca cccctttcca gcgatggctt cctctcagta taccgacttg 2168401 tacaatacca gcatctaata atttcatgac atctgtgctc cagcctgttt gtacactata 2168461 ttggacatta ggatacatag tggaaaattc ccttaataac ttagggagct tatattgagc 2168521 gaaattgctt gataccccca gccttagatg tccttgcacc tctttgctta gattagagat 2168581 atgatctttg gtatcttgaa gttcctgtag cattcttctt gcataagcaa ccaagtgttc 2168641 tccttccgca gtaaaggtaa ttcctttatg ccttttggtg aataattcaa ttccgaaaat 2168701 ctcctcaatc tttttcaacc gataagtgat ggaaggctgt gatgtaaata atcgttctgc 2168761 tgtttttgtt acactttgtt cttcgtgaag aattttcaat aaaatccaat ctttctcatc 2168821 cattttcatc ttcctttcta gtccttcttt cacaattata aaagtttttt tatcgaatat 2168881 taagaaaact tatattttat ttttattttt ttaccttcta cactaaaaaa cataaaaaat 2168941 actaccttta agatgaggat gatgacgatg gtcaagacga atgtaacaat catgagaggc 2169001 ggaacaagca aaggcgtttt tttccacgaa tcagccatgc ctaacaataa aaacgaatgg 2169061 gagccctttt tgcttgatgt catgggaagt cctgataaaa gacaaataga tggtttgggt 2169121 ggcggtaatt cccttactag taaagtggca ataataaaga aagcatatac ttcggatatt 2169181 gatgttcact atactttcgg tcaagtcagc atttcggaag aaaaggtgga ctttaagggg 2169241 aactgcggaa atatctccgc tgctgttggt ccatttgcta ttgaagaagg acttgtaaaa 2169301 gcgaaagaac caatgactgc ggtaaggatc ctgaatacca atacgaataa aatgatcatt 2169361 gcggaagtag aagtggaaga cggtcaggtc aaatatgacg gagatgttac gatatctgga 2169421 gtacctggat ctggatctcc aatctattta aactttcatg atgccgctgg ttcagttacc 2169481 ggtcatttat tgcctactgg aaatagttcg gagtttttag atacaagtca aggccaaata 2169541 gaggtgtcta ttatcgacta tgcaaatcca ttagtttttg tggaagcgag cagtatcggc 2169601 ctggatggaa cggaacttgc agaagaattt actgatctac agttggctca atttgaagaa 2169661 ttaagatcca ttgcggcaga gaaatgcggc tttgccagtc gattttcagc tacaaagtta 2169721 tcgccggctg tccccaaact ggctatagta gcaaaaccag agaaatataa agatagtaca 2169781 ggtgcttggc attcaagcgt tgagatggac ttacacatca ggatgatgtc catgcaaaag 2169841 ccacatcaag cactggctgt cactggagcg atatgtacaa caagagccct ttcagtggaa 2169901 ggtgcaatcc ctgcaagaat agcaaaaaac cactctacaa aggttcggct agctcattct 2169961 tctggtatta ttgaaacaat ggtggagccc actggtataa agatcgtccg taccgcacga 2170021 cgtattatgg acggaacagt ttatacgcat ggagactatc aaatgatgta gatggactgt 2170081 gcaaaaagcc tccccccttt ccatcgttaa tagatggatt gaatgcgcct tcttgcacag 2170141 atccattgta atcttgcatg gctttaaaaa agcctctata ttgtttttta tgaaatcgcc 2170201 aaggtccttt catgtatctg cctcaagcat gacataatca ttatagagaa aattgaatac 2170261 tttttactgc aaataaaaag ataccaacat cattggtatc ttttagattg agttcatctg 2170321 cagcggtttc ttttcctcac tgcttatttg attacaaaat taccgtactc gtttgaacga 2170381 acatgaatcg gtccgtttag attatagttg ttctccttgg cgatagagcg aagcacgtcc 2170441 acacgggcaa ctgattctct ccattcgtca cgggtgtcat gattggccgg attcatcaga 2170501 tcgtcatagc gtacgtccaa gaatttattc aaccacttct tctcgtctat tccgtcttta 2170561 ggtgatccgc ccgctttttt gttcgtacgt ttaatcaagg cataaaaaga gtcagggtca 2170621 tcaccatcgc catgctgaat aaccgtatcg tacatcacag ctcttgccaa tgctgttttt 2170681 agtccggcat tatccgatcg tttcatggca ggctgataat acaaatggtc atttactttg 2170741 tcttgagcgg cgcgaaattc cttatcattt gcaagcgact tccaggcaga agcgaatccc 2170801 ttgagattgc ttgtatcatc gctttcttcc ttggccagac ggcgcaattc aggcagatac 2170861 tttttcagtt tgttattcgg aactgccttt gtgtatactt ccactacttc caatgcatcc 2170921 ccggtagccg ttgtaaagcc tgcccgtccg catgtatagc ctcgcccgtc atccaatcgc 2170981 tctacatatc catattggat ctccgttgtg ccgttttcaa agatacttgt cagctgttcc 2171041 gcccggcgct tttgatcttt attcagtccc gccgcaaaaa ccgtttcgct catcatcagg 2171101 gtaaaaaaca tggtgaaaac aagtaatgag atcgctgctt ttttccaaaa atctgctttt 2171161 tgcatactga ttttcatttc acttcccctt tctaaatatt gtaaatacag actcagtata 2171221 catgaagaaa ctgccctatt gttgaaaata catcaatttg tcaatatttt gaatctaaag 2171281 taatatagct tgaatcttac tctattcatt gccaatcagc cttagcccct ctcactggga 2171341 aggtcccttg attttcatac tgcttcaact ttcattaaca agatgccata aggctttact 2171401 ctattttata atggaagtga tcatcgaaaa tcgttaggga ggtgatgtaa tggcaagcaa 2171461 gatgagaatg ccagattccg caacgtccca tgcaaagcct actattggga aggcgatact 2171521 ttgcatgggg tagactttct aaaagatcgc ccaagtaagc ttttctgata tagtggcttt 2171581 gcaccttatt tgacataaaa aaataaggag ctggcagaaa tggcatatgt aaaagcaacc 2171641 gctattttac ctgaaaagct gatatcggaa attcaaaagt atgttcaagg aaaaacaata 2171701 tatatcccta aacctgaatc ctctcatcaa aaatggggtg cgtgttcagg aacaagaaag 2171761 ctgatcgatg acagaaacgc ttctattaaa aaagcattta aaaacggcaa aaccattcat 2171821 caattatctg atgaatatca cctctctatt gaaacaataa aaaaaattgt ctactctaaa 2171881 taaacaaaac ggaagcactg ataaaaaata atcagtgctt tttatatggc gagtttgttt 2171941 cttagttatt tcctgcatat gataccattg gccaattgtg taaagttaag ggagatgaga 2172001 agaaaggaag gtcctacaaa tgacgataaa caatggaacg ttgcaagtac ccggcgcgaa 2172061 catccactat caggtgcgtg gctctggtcc aatcattctt ttggtccacg gaggaggcgg 2172121 tgatgccgac aagttccatc atgttgccaa tcatctggct aactggtaca cggttgttac 2172181 ttatgatcgc cgcggccatt cccgcagcaa tctcgccaat cagattgagg gttaccgtgt 2172241 ggaaacacac agtgacgatg ctcaccgtct tctagccaaa atcaccaata agccggccta 2172301 tgtatttgga agcagctccg gggctgttat cgggcttgat ctgtgcatac gccatcccga 2172361 acaagtacat gtcatgatcc cacacgaacc aatcttattg cagcttctgc atggaaatga 2172421 gctgaaacaa gccgagcaat tcatggaaga ccttaagaaa aatcatcgaa gtgaagtcat 2172481 taaattaatg tcaagattag agacagacga acaatcaaag gctgtcctga caaagcggct 2172541 tctcggcaat tcaacgtatt tcactgagta tgaaattcaa ggaattctca gctatacatt 2172601 agatttcgaa gcattaaaaa ctgtgtttac atcttcaccg atgaagatac tcccagctgg 2172661 cggaagtgct tctcgggagc tttttcctta tcgttgcgcg aacgccctag cggaacaatt 2172721 ggaaacagaa tgggttgaat tccccggaaa tcatacgggg tacacaatgt accataaaga 2172781 attttctgag aggttacacg acatgttaga aaaagaaaag aaacatacgt gttaaggatt 2172841 gattaaaatt ttcaaaatag gacaggtgaa actaactatg gaattggaga agatttcacg 2172901 aagcgtaaaa agaacttttc actaacgaga acgcaatgtg agatgtttaa ccaaagtgat 2172961 attagggatt tcatcgaaaa ataggtttgt acattacgtt ctcctattga ttatttccta 2173021 tcttaattcc gtattttata ccattagata caactctaaa gcggctcgtt attttgtcct 2173081 caacaacaac cagtgtctaa catcatgaat ctcttttgaa aatcaccaca aatgcaggta 2173141 tggaagactt catcgcagca aaaaccatac caactattgt tgttggtatg gttcgtccta 2173201 gataggccct taagaagaga ttctattgta cggagtattt agctaattgc atttgtaacc 2173261 gacagggccg tctgaacctg tgtacacata tgtgtcagac acatatccaa tattcacgac 2173321 accccgggaa tctttccact ggatttggtc ccagatatta ctcgttccat acttccctgt 2173381 aacagtcgtt ccataagcgt aacaataata aggaacacgg gagccactcg gaatggaaag 2173441 cataatagga taatttgtac caggaccgct gcgcatattg acaggcgcac cgctgcttgt 2173501 tgagacagta aagtactgaa cggcaagtgc ctgactggaa aaaatgaata aagatgcaat 2173561 catcacggtt aacatactca gcattttcag tttagtcaat gtcatccctc tttcttcaat 2173621 tccttcattt taagaaacga tagaacatag gctaccagct gcatttagga acaaccggac 2173681 cgtctgagcc tgtatacata tatgtatcag agacaaatcc aggaacgatc tccccgctgg 2173741 caagcgtccg ctctgtgtaa ttccaaatat tgctcgttcc atactttcca gttacagttg 2173801 taccggtttt gtagcaatag atcgggatgc gggttccgct cggaatggtc gttacaattc 2173861 cccaacttgt acctgggccg ctgcgcatgt tgacaggagc accgctgctt gttgaaaccg 2173921 tataatactg agccgcaagt gcatggctag aaaaaatgaa cacagatgca atcatcaccg 2173981 ttagcatact tagcctcttt aacttattca ccttataccc tccccttata aatgccgtac 2174041 gtttgacttt cttacatcca gttaaggatt tactttcaga taccatgccc cctcccctcc 2174101 catatattta tcaatgtacc ataaactaga tctttcaaaa gtggaattat tcctatgttt 2174161 tcgacaatta aggatacaaa ataaatggta gtcaggcttg atattgatgg tgtgttacat 2174221 ttggctctta atcatttgtc cagtcggtaa tcacgattga caatcaggaa aaaggacatg 2174281 gatcaagcgg cttcgtttcc accaattaac tcaatcagtg tactgcttcc ttgtatccac 2174341 gcttcttctc gattcataga tactccacct ttttcaccaa tcaaaaacgg acaccataca 2174401 aatcagcgta aatgctgcaa gttcagtgtc cgcaacctat tatgactttg ctttctttta 2174461 ccagggcgtg taaaaatgat taggtacgtt atcaaacgtt attctatgat tttgcgagtc 2174521 aaaaaatcat aacattttat atatttcaat cagattatga tctggatctc tgaagtgagc 2174581 aactcgggca ctccattcct tgcgatcatg cggtttattc tcacatttaa ctcctttttc 2174641 gtgtaaatcg tcatacgttt tatcaacatc ttctacctta aactgaagca aaaattttga 2174701 ttgagcttct ccttccaagg actttttttc ctctccaacg atttcagcca tcgtttctcg 2174761 agataaaagc tctattttcg tttccccatt atcaaagagt gcatattcca tttcattctc 2174821 taaccaactt attggaagtc ctaatgaatc tttataaaac tcgacgcttt tcttaaaatc 2174881 attcaccaac agtctaattt gtaacagctt catatcgagt gcctcctata aaaccatact 2174941 tttactggtc atccaattta atgataccaa agaaacctga cagcactatg tcaagtttcc 2175001 atacttcacc cttatttcag atttaagtgc agtttagtcc atgtcataag aacgagcaaa 2175061 aacagcgatt cttaaaacaa aaaatgatac cgagtgtatt ttctgtatgc ttcaacttca 2175121 tttcgggaaa tgtaacgttg ataaaaggag gttacatcaa tatggatcat caaacattgg 2175181 cagctcatga ggctgttgac ttacatgaaa tcgtgaactt taaaacactt tgtatagcga 2175241 aatcaaagtt aatgcaaggg cttgtgtttg accaagaact gaaggacttg atggaaaaag 2175301 atgtacagca atccattcaa gaccttactg aattacaagc ggtttatgag cgtgcctcat 2175361 ttcaggcccc tgtccctcaa agccgcccaa cgccaatcat caattgaaag ggaggtaagc 2175421 ctctttgaat aatgatcatt tagaccccat taattcgctg aatgtgcctg aactagcaga 2175481 cactacattc gcgatggatt ttcttatacg agctaaggaa ggcgtaagga atactgctgt 2175541 agctttgaca gaaaccgctt caccagatgt aagagcactg cttcggaaac agctgatgca 2175601 aggaattgcg atgcaccaag agattacgga actgatgatc agcaaaaagt ggttccatcc 2175661 atatgagctg agcgaacagt ataagctgga tcagctctct gcaaaaaaca cgatcatggt 2175721 cggcaatatg aacctctttc ctgatgaaac aaatcgcaaa gggatgtttg accggacacc 2175781 tgatgaacac taacactgga ggttttacag catgaaggca gtaacgtatc aaggcattaa 2175841 aaatgttgtt gtcaaagatg tccccgatcc aaagattgaa aaatccgatg acatgattat 2175901 caaagtcacc agtacagcca tttgcggatc agatttacat ttaatccatg gattcattcc 2175961 gaatatgcaa gaagactatg tcatcggcca tgaaccgatg ggaatcgtcg aagaagttgg 2176021 ttctggggtg actaaactaa aaaagggaga tcgggtaatt attcccttta atatagcatg 2176081 cggggaatgc tttttttgta aaaaccagct ggaaagccaa tgtgatcagt ctaatgacaa 2176141 tggggaaatg ggtgcttatt tcggctattc agggcaaact ggcggttatc caggcgggca 2176201 agctgaatat ttaagagtgc cgtttgcgaa ttttacccat tttaaaatcc ctgaatcttg 2176261 tgaggaaccc gatgagaaat taagcgtgat tgccgatgcc atgaccaccg gcttttggag 2176321 tgtggataat gccggcgtaa aaaaaggcga tacagttatc gttctcggct gcggaccagt 2176381 cggcctgttt gctcaaaagt tttgttggct aaaaggcgca aaacgcgtca tagcagttga 2176441 ctatgtaaac tatcgcttac agcatgcgaa acgtacaaac aaagtagaaa tcgttaattt 2176501 tgaagaccat gagaatacag ggaattattt aaaggaaatc acgaaaggcg gagcggatgt 2176561 agtcattgac gctgttggga tggatggtaa aatgagcgat ctcgagttcc ttgccagcgg 2176621 cttaaagctt catggcggaa cgatgagtgc attggtcatt gcttcccaag ctgttcgcaa 2176681 aggaggaacc atacaaatta caggtgtgta tggaggcaga tataacggtt ttccgttagg 2176741 agatattatg cagcgaaacg tcaatatacg ctctggacag gctccagtga tccactatat 2176801 gccgtacatg tttgaactag tatcgacagg caaaattgat ccgggagatg ttgtcagcca 2176861 tgtcctgccg cttagtgaag ccaagcatgg ctatgacatt tttgattcaa aaatggatga 2176921 ttgtatcaaa gttgtgttaa agccttaaaa aacggaggtt acagaaatgg aatacgcctt 2176981 acacgaagtg cttgaggttc aggaaatgac tgcatttaag acactttgtt tgacgaaatc 2177041 taaaacaatg aaagcactgg tatctgatcc gaagctgaaa gaaatcatgc agcaagatgt 2177101 tgatatcacc acacgccagt tgcaggaatt tgcctctatt ttatctaatg caaagcaaga 2177161 atgaggagat gaataaatca tgaatcctat catagaatat ctgactggca tgaatgttct 2177221 aacagaccaa atcattgcta tggacttatt aatttcagca aagaacggag tcagaaatta 2177281 tgcgatggca gccactgaag ccggaacgcc tgaagtaaaa gaggtcctta tccgccattt 2177341 ggaagaagca ctcgatatgc acgaacaact ctcaagctat atgatggaaa aaggctggta 2177401 ccatccttgg aaccctgacg aacaagtcaa gctgaattta aaaaatattg atacagccat 2177461 tcaattgcca accctttaac atacaatgac tgatttgctg aggaacagta ttgattggcc 2177521 acaactgttc ctcagcttca aaatgagcac tgtttgttcg ggtcctatga ccgtaaatag 2177581 attaaccgct tttctccatc tgatctccga taatgtttgc aaattctcca atccaaataa 2177641 ggaatcgtaa ccacctcttt ttatgcgatc tcttgatgga gaaaacaggc cagaaacaaa 2177701 atccttcgtt tttgacctgc cctcttcaca cgcaaagaat gctaccttct ttgctccact 2177761 gatccgtgaa gactttccgt tttaggcctg cttttgagct ttgcctcatt ttcacgcaat 2177821 ttcccatcat aatctttaat ttttgtgtct aatctcttaa ttgtttcatc aatttctttc 2177881 cgcttctcta tcagccgctg tcgttcgtca gccaggatat tttttcgagc ttctaccgta 2177941 cggtcacctt cggtaaataa tgttgtatat tcaattagcg cttctatcga tagtcccgca 2178001 tttcgcatgc atttaatgaa ttcaatccat ttgatatctt cttcatcata gtcgcgaatg 2178061 ccgctgtctt ttcgttttac aggcgggatt aatcctacac gttcgtaata tcggagtgtt 2178121 gcggctgtca ggccaaactg ctttgccacc tgagcaatat tcatgatctt cacctctcta 2178181 tcctgtatgt tgtgaaggta acacttaaag ttaactttaa gtcaagctca aaacaagtgg 2178241 ttagctgctg aatctgggtt tatatattcg ggacttgcct taaagcacac tttaaactct 2178301 atacttctcc atgcactaaa aacagtgtag ttggagggat tgctgaatgg caaataaaca 2178361 cactgccgga agagaacaat taggagaatt tgcgccaaag tttgctgaac ttcatgatga 2178421 tgttctattc ggtgacattt gggcaagaga agaagaactt tcatcccggg atcgcagcat 2178481 gattacagtt tctgcattaa ttactgactg tttctcagct tataaatcag gttcatttta 2178541 aatggttttt ttaaaaaacc cttgccttaa agcagacttt aaggtttatc gttatgttga 2178601 agacaccata aaacataaat aagtgcatgt ttttatttac aacacttatg atgaagaaag 2178661 gataggttcg tatgtgtaat caacatcaaa cccgtgtatt aagcgtgtca catgcaaaag 2178721 ccaaatttga acaaacgacg attgagcgaa gaggattacg gccgcacgat gtcttaatcg 2178781 atattaaatt cagcggcatt tgccattcag acattcatag cgcttttgat gaatggggcg 2178841 gtggcatctt cccaatggtg cctggacatg aaatagccgg tgttgtaaca gccgttggaa 2178901 caaaagtcac caagttggct gtcggggacc gcgttggtgt cggctgtttt gttgactctt 2178961 gcggagaatg cgaatactgt ctcaacgcag aggaacaatt ctgcacgaag ggtgttgttc 2179021 aaacgtataa ctcagtagac tacgacggaa accccactta tggcgggtac agccaaaaaa 2179081 tcgttgtcac tgacagattt gttgttcgca taccagatcg tttggaaatg gatgttgcca 2179141 gtccgctgtt gtgtgcaggt atcacaacgt attccccgct gaaacactgg aatgttggcc 2179201 ctggtaaaaa ggttgcgatt gtaggcgtag gtggccttgg acatttggca attcaatttg 2179261 cacatgcgat gggtgcagaa gtaaccgtcc tgagccgttc catgaataag aaagaggaag 2179321 ctctggaact cggtgcaaat cattactttg caacaagtga cccagccaca ttcactgcat 2179381 tggccgggcg ttttgacgtg atcttaaata cggtatcggc aaatctcgat gtagatgcct 2179441 atttatcaat gcttcgtata gacgggacac ttgtaagcgt tggagctcct gccaagccgg 2179501 acacatacag tgtgttttcc ctaatcatgg ggcgccgcag cattgcaggt tctctagtcg 2179561 gcggaattca agaaactcaa gagatgctgg atttcgcagc tgagcatggc atcgaaccta 2179621 aaatcgaagt catcggagct gaccaagtgg acgaggcata cgaacgtatc ctccgaagcg 2179681 atgtccgtta tcgatttgtg attgatattt ccacattgta ataggttagt ccttatatgg 2179741 gctgccgctt ttattgaaac tcacgaaaaa tgatctcttt aagcaaatat tttgaaggcc 2179801 ggtcaatctt cctgttattc tatgaataga gagttattag gagggttttt tatgagcaaa 2179861 aaaattgcag ttcttgttac agaccaattc gaagacatcg aatatacaag tccggtaaaa 2179921 gcatacgaag aagctggcta cagtgttgtg gctatcgatt tggaagccgg caaagaagtt 2179981 accggtaagc atggcgagaa agtaaagatt gacaaagcca tctctgatgt ggatgcaagt 2180041 gactttgatg cacttttaat tcctggggga ttctctccgg atttgcttcg tgcagatgac 2180101 cgtccgggtg aattcgcaaa agcatttgtc gaaaacaaaa aacctgtttt cgcaatttgc 2180161 cacggcccgc aagtactgat tgatacggat cttctaaaag gcaaagatat cacaggctac 2180221 cgcagcatcc gcaaagattt aatcaatgcc ggtgcaaact acaaagatgc agaagtagtc 2180281 gtcagccaca acattgtcac aagcagaaca cctgatgatt tggaagcatt taaccgcgaa 2180341 tctttaaact tgttaaaata acaagaaggc acagactgtt cgggtctgtg ccttttttaa 2180401 aattaagact ccttcgttac attctgaaag acagcagtcg cgtcccacac attcaagcca 2180461 aattggcctt ctgaaaatac ggaatcatgt gcatcaatca caagacgatc atctaaatag 2180521 attttaaagc gatcgccctc ggcctctgtt ttcagatgat actttttatt aacgtctatc 2180581 ggtgttttgt attcagcaat gacagaagca gcaccgttct caaatttaaa gaatttcact 2180641 aggtcatgct tcgcatccac attggcaagg taaccgtttt tggcatcttt gtcagagcga 2180701 aacattagtg ctcctgcccc tcttccgttt ccatccttaa tggtgatatc agattcataa 2180761 gtgaagtctg acccggatgc tgaagacaag ataaaggaat cgccgtccga cctcccttgt 2180821 ttcccctcaa ttgtgtctgc ccacgtgcca tttacagtcg tccagccagt catattggac 2180881 ataaaaggtg tcgttcccca tacctttttt aaagggtgta tcgttaaaga ttttaccttt 2180941 acaccgccat ttgcagcata taattcaagc cctttgcttg atcggtctgg gagaataata 2181001 tccgttatga cctgctttcc gtcattccca aatacttcaa ccgaggagcg gtcaacaaaa 2181061 atgcgcaact taaccttccc atttaccggc ttcaacgggg ctgtttcttt tccggtgtta 2181121 aaggccggat taaaggtgtc gttgcctgac tcgctccggt caacgaacaa tttggcgttc 2181181 cttcggtcat agccgacctt cgtaaattga ttttcacctg ttcggacctt aaaaccaaat 2181241 tcagcagctg aaccagggct tactttaaat tctgcattta tttcataggc atctccagat 2181301 tgccccgcta acacattatg acttgcaggc gatatggtca gattcttcca cttcttagag 2181361 gttccgcgaa tggtttccag ctctttcacc ggtgtttgga ccactctaac cccttcggta 2181421 aacgctttca attttaactc tcttggaatg gacgttgcac ttctccatgg ggatgtcgga 2181481 acatcattcg catattgcca attgctcatc caccctaacc atagccggcg gctgtctgtg 2181541 gatggaatat cagaccagga tacagccgca taaaagtctc tgccgtaatc cgtccagaga 2181601 actttgtttg gcgggttttc atttttaaaa tgagttccat caaagtcccc tacaaaatat 2181661 tgcatgcctg atcctcccga gaccgctccg tttccgacac tgacctgcat gacccatttc 2181721 ttttgattcg gattgccgtc taccggaagc tcaaataaat ccgggcattc ccatactccc 2181781 ccgtggcttc cttgatcctg tccaaattca cttgcatacg tccactgctt cagatttttt 2181841 gatgtataaa tgaggattcg gtcaccggcc gcaagcacca tcacccactt tttttctttc 2181901 tcataccaaa agacttttgg atcgcgaaaa tcttttttac ccgggtttgg aatgacaggg 2181961 ttgccagcgt acttcgtcca tgttcttcct ttgtcgttgc tataggcaat actttgcact 2182021 tgatggcctt cccgatcctg tgtataaatg gccacaagcg gcttctcttt gcctgtttga 2182081 aaaccgcttg tgttattttt atctacaact gcgcttccag aaaagatcgt gcctttttca 2182141 tccggataca gcgcaacagg aaggtgttcc catgtaacca aatctttgct gacggcatgc 2182201 ccccaatgca tgggccccca ctgaagcccg tatggatggt attgatagaa caagtgatat 2182261 tccccagcat aatataccat tccgtttggg tcattcatcc agtttgcctc cggtgtgaag 2182321 tgatattgag gacggtaatc ctcatcatag tagcttgaat cggctgcatc tgccgaaaat 2182381 gccatagtca acagcagggt gaacatgatc atgacttgaa tcagtctctt tttcatttgt 2182441 tccttcgctc ctctcttcat gtttgaacac tttcaaaaga gactgctgcg caagctggtc 2182501 cgtttctggc aattctcctc tgtttcactg ttatccgaat gatttatata tgaaaagact 2182561 gctgcagttt ctctctcttt ccttcacaca ccttatgcta agaatccagc ccaatacccg 2182621 agaatcccga tgacaaagat gccgcaaata atgagaagtg gattcacccc tttgcgaagc 2182681 atccatgcca ccaataacgt taatccgaga ggcagcgccc ccggcataat gctatctagc 2182741 acgttttgta ccgtttgaac atctactttt ccgctttcat ccttaatcct ggatacaacg 2182801 attggaatgt tgatggtggt ccatttggac acgagagccc ccataacaaa taacccgaga 2182861 atcgaagcgc cctctgtaag cttttgaatg cgattccccg ctaaatcctg aagaatctcc 2182921 attcctttca catagccata ctttaatccg taatattttg tgcttaatct tatggcattc 2182981 agcaagaaaa agaatagcaa aggaccggca atgtttcctc ctaaagcaag ggaggctcct 2183041 agcgcagcta agacaggacg aatcgttccc caaaaaattg gatcgcctac gcccgctatt 2183101 ggtcccatca aaccgatttt cattccgctt atcgcttttc cgtcaattcc tttattgttc 2183161 gccatttctt cttccatggc tgccgtcacg ccaaatatag gcgctgtcag ccacggatgt 2183221 gtattaaacc attccaaatg ccgctgtaag gcttcgtttc ttttcgctcc gggaccgtac 2183281 aattttttga tcgccggtat catgacataa caatatccca ttgcctgcac acgttcgaag 2183341 ttaaaggaac cgagtaaaaa atttgaacga ataaacatgc tgaaaatttc tttcttcgtt 2183401 aatcgttttt ctttctccat tttttcttcc ccctcatcgt ttaggcatca agatcatcat 2183461 catcgtcatc ataaacagca acactgccac tgtctgatgc ggccgcgact gctccgtgag 2183521 cgctttgttt ttgcatcacc tgctggtata aaagcgccag acagagacca agggctccaa 2183581 atcccactaa gttaaaatcg gtaaacgccg ctaataagaa accaatatag aaaaatggct 2183641 ttaaataagg aatattcatc atattgatca ccatggcata cccgacaacc acaataatgc 2183701 ctccgcctat ttgcagtcct tttgtaatga catcaggaat atttcccagg aacgcctgaa 2183761 cagcgctgac actaattaaa gcaacaatca atgtaggaat catgacgcgc aaagcttgaa 2183821 acaccatcgc ggtaatatgc ataatttcaa ttccttttat atttcccgct tttgcatatt 2183881 gatcagcgcg gtggatgaaa aagacagtga tcgtccgaac aaaaatcgtc agcgcctgac 2183941 ccgcagctgc taaagcaaca gcgacagcaa tcccttcgcc aattccttga tcagcggtaa 2184001 taactaaaat ggttgagatg acagaggcga tcgctgtatc aggtgccatg gcaagcccga 2184061 cgttcatcca gccgagcgcc atcagctcca gtgtgcctcc aagaataatt cccgttttta 2184121 agtccccgag caccaagcca accaacgtac aggccactag cggccggtgt gtctgccctt 2184181 catccaatac acttgcgatt ccggtgattg ctgcaatgat taacaacaaa ataatttgta 2184241 atgaagacat attctcatcc ccttgattat tttgttacgt tccgtaaaat ctgtacaaaa 2184301 tcctcactgg catctgaagg cagctgcctc aattccagtt tcacgccctt gtcacttaat 2184361 gtttcaaatg cctttatatc ttgttctgtg acactgactg attttgtgat ttgcctgcga 2184421 tgattttcaa aacgcattcc cccgacgttt acggttttga tcggtacacc tgcttctata 2184481 agagatacaa tatcggacgg attttcaaac aagagcattg ccgttacccc ttcgtagcgc 2184541 ggactatgaa atgcttttgc cattttagaa accgagacgg cactcgcctt tacatttgaa 2184601 ggcgcaacag aaaggatcag cgtttttctc atttcgtcct gagcaatatc gtcggagaca 2184661 acgatgattc ggtcggctgc atggactttt atccaccttg tcaggatttg gccgtgaata 2184721 aagcggtcat caattcttgc taacacaatg ttcatcataa ttcatcctct cttgtatctt 2184781 gattggctgt ttttactttt tctaaatgtt cactgcacac ttgaaagctt tgctgactca 2184841 ttgcttttaa gttgttcagc aaatctttga gagccagatg ttctctcagg cttaatacct 2184901 ccagcagaat cggcaggttt acgccggcag ccatatccat tctttgatcc tcagcaataa 2184961 aggaagctgc cgcgttatat ggcgtccctc caaaaatatc gactaaaaaa agcacttcat 2185021 gttcttccgg gatatccttg agcgcctgat gatatttttc ttgcagcgtt tgtattcctt 2185081 cccctttgaa aaacggcact gcaatcaggt tattttcttc accgaatatc atccctgaag 2185141 actcttttaa tgctatggga aaatctccat gaccgctgat aataactgaa atcatatcta 2185201 ttgctccttt cctgttttgt acatccatat ataatgcaag gatcgtgcca acacagttgt 2185261 gttaagcgtt ttcattgtta tttcagccaa tagcaatttg ttgttgaaac acttaaaacg 2185321 aaaaaaataa acctgtatta aaatggtgtt ccatttaata caggttcata tgaaaaaact 2185381 gtttttaaaa cagctggcca tgcacttctt cagcaaatat ggcggctata aataattttt 2185441 catcatcact tatgcgaagt ccgagctttt cttcataagg ggctaatgtt cgctctgtca 2185501 cgtacaccat ttccttcagc tgatcattga tctcttcttc ctctgagaaa gcgatcggat 2185561 tctgcttaat taccctttca aaggcgaaag ccgtgtgcat aatgactttg atcaaaaccg 2185621 cattattgaa aatgaccccc agctcatcct gaacggtttg cagccactcc aataacatgt 2185681 cgatcacatg gtggggattc aagaagacaa ggtatttttt caggctatcc tcgcaaagct 2185741 ccctgacaat aatatttgct tcgttcaatc cattgctcaa ggagatgctt ccttttgtaa 2185801 tcgcctgttg aatcagcttc tctccctccc cttcaattaa cacttctaaa gatacatgcg 2185861 gagcattgat tttagggtct ttcgttccga ctgtcgcaag gatttcatac tctttttcga 2185921 tttcttttat gctgttggcc agcttaatcg atgatacggt caatatgtga atgggggtat 2185981 cggaggcctt gtttacgatc gtggttagaa tgtcttccag ctttttggcc gttccgctac 2186041 ccgtcgtgca gatggatacc aatgccttct ttttgccgga tgccgctggc tgacgctccc 2186101 acaactcgat aaaatccttc gtgaccgatt gatagatcgc atgcaaattt aaattcaaat 2186161 agttgacctt tctgacagca tccagcacca ttgaagtcgt aacattgctg atcgttttaa 2186221 tagaaatgcc tgtcttttcc tccagcctgc tttccagcat tgcaagcgac cccatatcta 2186281 ccagcattaa aacaccttca ccttcatcaa cctgtttcat tttttctgct acgcattcaa 2186341 gaatgtccga aggtgaaaca gtaagcggca tgtcaactgc tgcaatcggc gtactcccta 2186401 gcagttctgt cgcgacttca accattgaac tcgccgtgct gtttccatga gctgccacga 2186461 taataccgac tcttttgttc tcctttaacg atttgatgga atgaattaac atcgttaagt 2186521 agatgacttc tatttcagga atagccactt taaaatattc ctgaatttta tctttaaaaa 2186581 tcatcgccac ccgatattct ttcacatggg tatcacgaat ttcatctgtc tcctgtgtat 2186641 tcaaaacatc aatttgcttt cctcgcttta aaaatgcgtc aatatgcata ctcaagaaat 2186701 aaataaactt acggtcaaat gtgcaatcca gctcatgttc agctatttct tttaactgtt 2186761 ttgtcatttg aatcacatcg tcttcaacga atgtcagcag gttgtctttt tgaaaagctt 2186821 gatgatgaaa aaaacttctg acatgcaaat ggacatcagt caagatgtac tggttaatat 2186881 cctttttgga taaaccttct ttcataagcg ttttcacttt ttcctcaatc aaatgatata 2186941 agttaaatga gaggtcttcg tcaatttttg ttgtttcatc ttctacaatc ggagagataa 2187001 tcgttgtaat attgacatat tcagaaatgg ctttgcttct ttgcatgttt ttgctgctgg 2187061 acatccattc ttgcttgatt tcatcaggca gatcgcgaac agtcagttca ataacttcat 2187121 ttctgtcaag gttatgcaaa aatccgtgtg cgcaaactaa ctgaacattt gatttcagct 2187181 gtccgacatt cccaaatttc gcagagtgaa taagcgcatt atagacatcg atatgcacac 2187241 tcagattctt cttaattcgc tctgcttctt tccctaataa aaacgtcgtc agatccactc 2187301 tttcattaag cgatcgttct tcaagcgaag gaatatgaat ggtcattggg attcttcgca 2187361 aaaacgtttt caatagtgca gaactcggat tttctgtagt cgcacaaata aacaatacgt 2187421 tcgatgttcg tttatgttca gattctccaa gcctgttata agaaccgctg tcaataaaat 2187481 aaaacagcat ttcttgtccc tcgggaggga gacggtggat ttcatccata aaaagaatgc 2187541 ccccattggc ctgttcgact aaacccgcct tatcctcggc agcacctgta aatgaacctt 2187601 ttttgtgtcc gaataattga gaaagcaata attgagggtt gttgtagtag tctgcacagt 2187661 taaatgtaat aaatggtgcg ccggccttca atatgtcaga gtaaatggca aactggtaaa 2187721 ttcggttcgc aaaaagggat ttaccggaac cagtcggccc taggaggagc atatgcagac 2187781 cgttcggcgg ataaaagaca gctgcttttg cctgggagat cgctttcttc aaactccctt 2187841 ttgcccctat cataagctct aggggattcg tggaaatgtg ttgatgattt tgctttgaat 2187901 ttccggaaaa cgcctgaagg tctttcactt ccatcatctc tgtatcccat ttcttgttga 2187961 ataatttttc tgctatctcg actgggatgt atcttacagg aaatgtttta attttgatga 2188021 cctttttgga ccggacgaga ttgttcaatt caaagctgac attggaccgc tccattttca 2188081 gctgctcggc aatctccttt gctgaattcc cttgtatttt taaaagatga tctaaggttg 2188141 aatcatgaaa attatgcttg agctgatggt atattttatc tattcttctc acgtctatca 2188201 tcctttgtcc ttattagata agccattaac aagaatattt cgaaacttta tagtccgcgt 2188261 tgagatttac acgtttaaaa aggtctctat agcagattga caaagctggc ttttatgcgt 2188321 atatgtttac atgttgaatc atttgcacct catattagta tgatagatgc tcagttctgg 2188381 agggccagtc cccttcaaaa gtaataatca gtaaacagtt tatcattctc ggggaatgta 2188441 atgatgtcaa aataatcaat gacaaaaaat gaatcttata gatcatgaca aattacccaa 2188501 atataacccc ttaagttcgt tcacaactaa aaagacggac actctatgtg accgccacag 2188561 tattacaatt tgcaaaactt cgtcattttt gcaatccaca ttggaggtta aggaatctgt 2188621 aagcttaaaa actttatctc cgatcctatc gatttgatcc ccctgccggc ctcaatcata 2188681 gtgggtatgc aattatacaa atcgttaccg attaaaacta gcctgtcaga ttgtccaaat 2188741 gactttcctg ttttactctg ctattcaggt agaatcacga gtgaaaaata gagccacaag 2188801 acatgtaaca gcacttaaaa tagttttaaa atttaaaaat aaaagtatct attcttttaa 2188861 atgttataat atccgataaa actttactca tctttttatt actggaggaa aataaaattg 2188921 ataggcaatt ctagcaaaga caattttggc cagcaacaga aattgtctag aggccttaaa 2188981 aacaggcata tacaattaat ggcgattgga ggtgcaatcg gtacaggttt atttttaggt 2189041 tcaggtaaat ccatccattt tgcaggacca tccattttat ttgcttactt gatcaccggc 2189101 gtattttgct ttttcattat gcgttcgctc ggagaactgc tcttatcaaa tgcgggatac 2189161 cactcttttg ttgattttgt aagggactat ttaggaaaca tggcagcatt tatcactggg 2189221 tggacctact ggttctgttg gatttccctc gcgatggctg atttaacggc ggtcggcatt 2189281 tatacgcaat attggcttcc cgatgtgcct caatggctgc cgggtcttct tgcgcttatt 2189341 atcctgctga tcatgaacct tgccaccgtt aaacttttcg gagaattaga attttggttt 2189401 gcattgatca aagtcattgc catactggct ctgatcgtaa ctggtattct cctgattgcg 2189461 aaaggttttt ccgcagcttc cggccctgcc agcctcaaca acctttggag ccacggcggc 2189521 atgttcccaa atggatggca tgggtttatc ctatctttcc aaatggtcgt cttcgctttc 2189581 gtgggtattg aacttgttgg actgacagca ggtgaaacag aaaatcccca aaaagtgatc 2189641 cctaaagcca tcaatcaaat tcctgtccgg attttacttt tttatgttgg cgcacttttc 2189701 gtgattatgt gtatctatcc ttggaatgtg ttgaatccaa acgaaagccc atttgttcag 2189761 gtcttctctg cagtaggcat cgttgtggct gccagtttga tcaattttgt tgtattaaca 2189821 tcagccgcat cagctgcaaa tagcgcttta ttcagcacaa gccgaatggt ctattcactt 2189881 gcaaaggatc atcacgcacc tggactatta aagaaattaa cttcttctaa cgtgccaagc 2189941 aatgcgctgt tcttttcatc catcgccatt ctgattggcg ttagtctgaa ttatttaatg 2190001 cccgagcaag tcttcacgct gattacaagt gtttcaacaa tatgcttcat ttttatttgg 2190061 ggcatcacgg tgatttgcca tttgaaatat cgaaaaacaa ggcagcatga agcgaaagca 2190121 aacaaattta aaatgccttt ttacccatta tccaactatt taacacttgc atttctcgcg 2190181 ttcattcttg tcatattggc actggcgaat gatacacgta ttgctttgtt tgtcaccccg 2190241 gtctggtttg ttttattgat tattttgtat aaggtgcaaa cccgcagagg acataaggtg 2190301 aaataaaaaa aagacaaggg atactcactc ccttgtcttt ttatatgtgt caaacactaa 2190361 attaaacttt ggtttcaaat ttcattcact tcatttaagt gttaactcaa accagttttg 2190421 atgccgaaac ctactaatat tattccggta attttttgaa acactttctg gaacttcgag 2190481 tttttcatcc atttttttgc gtaatcaata atataaacaa gaaacaggaa ccacaacacc 2190541 gctaataagg ttaggattga agctaaaatg atgagctgct ggtttatatt tccgttcaaa 2190601 ttgataaatt ggggcatgat tgtaacatac accaaaacag ttttaggatt gagaatgtta 2190661 ctgagtgatc cctgcataaa ggaagtttta taataacgtt tcggagaact tgccatattt 2190721 tttgcttggg attgcatgtc atctaacgaa aacatacttt tagcaaaaaa actttttaca 2190781 cctaaataaa ttaagtatgc cgctcccaaa tatttgatcg ttgtgaaaag aatcactgac 2190841 tttgcgatta ccactgataa tcctaaaatg gcaatcaccg tccaaaagga aagtcctgtc 2190901 gccaatccga gaatgttata acggccggct ttcggaccat acctaagcgt atttttcatc 2190961 acaagcatcg tatctgcccc cggtatgata accatcatgg cagcgatcgg tatgtatgcg 2191021 agtaagctgt gcattgttct ctcccccttt aaaaatcccc tcaatcatat agtgactaca 2191081 aaagtaacta cttataaaag tgtatcaatg cgtttggaat aaatcaatat gatttgttaa 2191141 aatagcgatt actaaggcag cgattgctct ttatattgga ggatatatga aagaaaatat 2191201 gttagacatt ttaaaaaacc tcaattttac agaatatgaa tcgaaagcgt atttagcatt 2191261 attgcaagaa tcacctttaa caggctatgc cgttgccaaa aaatccggag tgccccgttc 2191321 taaaatttat gaagtattgg aaagtcttgt cataagggga gatgtttttg tcagtcatgg 2191381 aaatacgcct cagtatgttc cagtccccgc aaaagaactg attaaaaacc gccggctcaa 2191441 agcggaagag cattttgatc aggctgagaa atattttgaa aagttcgagc agaccgcaaa 2191501 tgaccgggaa aacatctgga atatcaccgg ccgcagtgaa attcttgaaa aggtgaaggc 2191561 ttgtatctta tctgccaaaa aaagaatcct cttagaaata tggaaagagg attttaagga 2191621 gatagaagca gagctcaaac aggcggcaga acaaggcgtt attgtcacca ttattgcgta 2191681 cggagacatc gtatctgatt ttgccaatgt ttaccttcat gatatgagca gtgaaattac 2191741 agaagagtat gacggacggt ggcttgtcta tagcggagat gattcagaag tagtagcggg 2191801 cattgtctca cttggcaacg acagccgtgc tgcatggacg atgcatgtag ggttagtcat 2191861 gcctattact gaagtgatca ttcatgatct gtacctcatg gaaattctga aaaagcatag 2191921 agagctttta gaagagagct tcgggaaaaa tctcatccag ttgcgccgta aattttctat 2191981 tcactcagat ttcaaaaaac attatttgga ataatgtttg tcatctctta ccccaaaaac 2192041 aaggcttgta caaaacaagc cttgtttttt tatgcataaa ccccccatgc tgatttactt 2192101 ctctctttta aaaaatgtga ttctgcgcaa actatttttc agcctgccgc gtctatccta 2192161 ggtaacagcc tacgatatac gtatattcaa aaaggagccc tttattgcaa tgaagaaaaa 2192221 acaaacaaca aaagcgttgc ttgtcacatg cataactgac cataagcaag atttctacag 2192281 gttggctttc agttatgtga aaaatcaaga tgacgcatta gatattgttc aggaatctat 2192341 aaaaaaagcg ctgagctcag ttgaaacggt caggaaccct gagacgataa aaagctggtt 2192401 ttataaaatt ttagtacgga cagccattga ctttttgcgc aaacaaaaaa agataagagt 2192461 gatggacgac gaaacgatag aatttttaag caaaggaaag gaagaccatt acaaggatac 2192521 tgatctccat gaagcgcttg acgaattgcc gtaccgctat aaaaccatta ttattttacg 2192581 tttttttgaa gacctcaaat tagaagaaat tgcggaaatt acaggagaaa acacgaatac 2192641 cgtcaaaacg cgcctataca gagcattgaa gctgatgcgc attcagttga cgaaggagga 2192701 tctttcttaa tggataagag attacagcaa ttaagagaag aatataaaaa tgttcagatt 2192761 cctaaagaat tggatatcat tgttgaaaaa gcccttcagc aagaaccaaa aaagaaaaga 2192821 atcgttatgt ggccgacatc agcagcaatc gctgcagcta ttttattcac tgcgcttgtt 2192881 aatatcaacc cggacgccgc tcaggctatg tcaaagatcc ctgtcatcgg caaaatcgtc 2192941 aaagcgatca cctttattga aatcaaagag gaaaaagacc aatcaagcat tgatgtcaaa 2193001 acacctgctt tgtccgggct ttctaataaa gagcttgaaa acagcattaa cgagaaatac 2193061 ttgaaagaaa gccagcagct gtataaagag tttatacagt ccacatccaa aaacaaaaaa 2193121 gggcatctca gcatctacag tgattacgag acggtcacag acacgccaga tttactctct 2193181 atccggcgca atattgaaac aacacaagca tcttcctaca cacaaagccg ttatattaca 2193241 attgacaaaa agaatgatat tttacttaca ttaaaaagct tattcaaaga tgagcgctat 2193301 atcaaagtca tcagtcaaaa catcaaagaa caaatgaaac agcaaatgaa ggaagatcca 2193361 aataaaatat attggctcac tgacgaagat gcagaaccgt tcaaaacgat tcttcctgat 2193421 cagacgtttt acattactga agaccataaa cttgtgatct catttgacga atatgaagtc 2193481 gcccccggct atatgggcgt tacagagttt acaattccaa ccggcgtcat ttcaaacttg 2193541 ctcgtgggag aacgttatat tcgataaaat aaaaacatcc atctaagatt atggatgttt 2193601 tctctcttct ctattcgagg tcgtaacccc gctatcaaaa acaacgagaa tatttgcata 2193661 ctattggagg aatacccatg tatcacaaga cacagcatca tcgatacatt cctggacttg 2193721 atggccttcg ggctttcgcc gtcctgtcag ttatcactta tcacctaaat ttcaattggg 2193781 ctaacggtgg ttttatcggg gttgatatct tttttgtttt atccggatat ttgattacat 2193841 ctattctatt accggcatat ggaaatgata tcaatcttga ttttcgggat ttttgggtgc 2193901 gccgcattcg gcggcttctc ccggcagcgt accttatgat cttttccact gttgtgtggg 2193961 tcgtattgtt tgatcgagaa ctattgcaca ctgtacgtgg agatgcgatc tcttctctct 2194021 tttatatgag caattggtgg tttatttttc acaagctatc atattttgat agtttcggtt 2194081 ccccatcacc tctaaaaaac ctttggtcgc tggcgattga agaacaattt tatatcatat 2194141 ggccgatgtt tttagttgtt ggaatgtaca taatgaaaag ccgcgccaga ttggctgcgg 2194201 tgatatcatt gcttgtgctt tgttcagccg tgatgatgag cgtactgtat gaacctggcg 2194261 gagatccgag ccgcgtttac tatggcacag acactcgttc gtttgaactt ctcatcggat 2194321 gtgccttggc tttggtatgg ccgatgaaaa ggctgtcttc caacaggctg ccaagcaaac 2194381 tgaagcacac tttgcacgcc actgaatttt tggcattttg tattttagtg ttgtgtgtct 2194441 atttcacaga tgaatacgag ccttttcttt acagaggcgg aatgctattc attagcgtga 2194501 ctgccgcaat ccttattgca tgtgtttgcc atccgagcag ctttttaggc aatctgcttt 2194561 catggaggcc gcttcggtgg cttggaacga ggtcttacgg aatttatctt tggcactacc 2194621 ctgttattgt gttaagcacg ccagttcaag aaatcggaaa ccctgttttt tggcatatcg 2194681 tgctaaaggt cattgtgaca tgtatacttg ccgagctctc ctaccatttt attgagaagc 2194741 cgatacggac acagggattt aggtcatttt cccgccgtgt ttttatacat agaatcaagg 2194801 aatggaaaac gacatctgtc atcagcaaaa tgtcaattgg tttcattatt ttcgctatac 2194861 ttatttttgc aggcgggctg tcagggctag ccggcgagca aaagcaccct accaaatgga 2194921 cctatagctc acaagaaaca aatgctgaca ccagccaggc ttctggggat aaaaagaacg 2194981 ctgcagcaga taaaaaacac aatcctgaac aaaagacaac agattccaat cagggtcaaa 2195041 aggaaaacaa agatagtggg caagagactc ataaaaagaa agacacgcaa tcccaacagt 2195101 tgaaaaaacc agcagacact gcgaaagaag ttttagctat aggagattcc gtcatgcttg 2195161 atatttcttc acacctgcgt cagtcatttt caaatgtgac gattgatgga aaggtaggga 2195221 gacaaatgtc tcaagctttg gaactcgcaa gggaatacaa gtcttttaat cagccgaaca 2195281 aggctgtcat cattgagctt ggaaccaatg gctattttac aaacagccaa atcgaacaac 2195341 tgcttcaatc tttctcaaaa gctcatattt atcttgtcaa tacacgggtt ccccgccaat 2195401 gggaaagcaa ggtaaatgaa tctttgcagc aacaggccca cgcacatcaa aatgttacgt 2195461 tagttgactg gcatacagaa gctcttcagc atccggaata ttttacccct gatggtgttc 2195521 acttggttcc taaaggggca aaaactttga ctgctcttat tgttcaggcg atgaaatcgt 2195581 aaaaaagaga tcctatacag atcacttttt tactttagtt tctgatcgtt gattatgtct 2195641 tctttcagca aggcagccct tatgtttaca tgccgtttac gtaagggtaa gccaaaattg 2195701 aatggaggga tgataatgaa aggaaatgaa gaacatgaca tccaaaaaga gttgaaacga 2195761 tatgagcttt ttttcaaaaa acgatataag gttctttata cagtaaacga ttttatcatc 2195821 ggtgctatgt ttctcgttgg aagttttttc tttttttatg accggttaat gtcggcaggg 2195881 atatggctgt ttgcgatcgg aagtttgctg ctgttaatca ggccgaccat tcggctgatt 2195941 catgactttc attaccgtaa gcatgtggaa cagcaattca agcatcaatc ttcaacagat 2196001 gactgatctt aaggaataag aaagaacaaa atgccaaaag cctgagtcga aaatcaaaaa 2196061 caagactttc agactattta tttttaaaaa caaggtaaaa agaactaaac ttttgcctct 2196121 gcatgccgat atgaataata aggccggcgc gatactccct ataacatcct tttcagtaga 2196181 tttcattatc gtgccggttt tctcatatgc aaagcaatcc cgccaatcag attggcggga 2196241 ttttatattt tacattcctg tccaaacgtc tttcacataa cgtctttgat cttgcagctt 2196301 ttgcagccat acagctgatt cttcctgact tgctgctttt tcagcttcat atgccaatcg 2196361 caaagttctc tctacatcag gagccatttg cgatccatca ccgcatacgt aaatatgagc 2196421 ccctttttca atgagtgtca tcaatttctg cgtatcttgc ttgagcaagt gctggacata 2196481 tccttttggt tcgttttcga cgcgcgagta gcatcggcgg attgtgacca aaccgtcctg 2196541 ttccgcttga tccagctctt ctctgtaaag gtcgtcatgg tccgggcggc ggcagccgaa 2196601 gtataaaagt gcttcaccaa gggtgcttcc ttccttcttc aaaaccgatc ttgcctgaat 2196661 aaagcctctg aatggcgcaa ttcctgtgcc cggcccgacc ataatcatag gcgtttcagg 2196721 atcattcggc atctgaaatc cggactgcgg cgtacgaatg aagcaagctg ctgcatcacc 2196781 tgtattcaat tctgctaaat aattagaggc gacaccccgg tattcacctc ggccgctcca 2196841 tgctgaggct ttcacaactc ctaccgtcat gctcacgata tttgcatgaa ctttcggtga 2196901 gcttgaaatg gaatagtatc tcggttttag tgatggcaaa agtgctaaaa accgttcaaa 2196961 cggcatttcg caagcaggat aatcctctaa aaaatcaagc atggtaagac gttttgcaag 2197021 tacctgctct ttgtaaatgc catcatctga aacgagctgt tccagctctt tttgatgcgg 2197081 cggacaaact gtataagagg ccagctcccg aagctgaagc cttgatgccg gttcctgcag 2197141 ctctacatag gacgacaata aatccactac tttgattggc cgatccatcg gcagatgagc 2197201 catatgagcg cttccgctta cttttatcac atgattggac tgcaaaccga atcggctgag 2197261 aacccgctga acaagctccc tgctgttctt tggcaggatt ccgatatgat cgccttcttt 2197321 atatgtttta ccagccggaa tttccaattc aatatggcgg gttgaacgcg tgctggcagc 2197381 tgtctggagt tctcgattct ctaacacaat cccttcaaac gcgccatatg ctttagcaac 2197441 cggcgtttcc gtcgcttcac tgagaaaagt aatcgataat gaaggcctgt cttctttctg 2197501 ggctatttcg ttaatatcaa atgcgtccat cgtttccttc cagaagcggt tttcccaaga 2197561 ctcgcggtgg ctttcaaaat catcggcggc gtcaccttcc ccaatcgctg ttaaacgcga 2197621 tgcccccttt gctttcatca tgtcatcaat caggcgggga atccgctgat acgtgctggc 2197681 ccagctccgg tttccgcagc cgaataccgc ataggaaaca cctttcaatt ggccttcctc 2197741 aagctctttc agccactcta caaatccggc agcattatca ggcggcgccc cattataaga 2197801 agccgttaca atgacgactg ccccttcttc agggagcttg ccgatataat catcaagcgg 2197861 agccgtttca gctgtaaagc ccatctggcg gccttgagca gccagttcac cggctattcc 2197921 ctcagctgtc ccaagatttg aaccaaaaag aacaagtaaa ggtgtgccgt gtttaggttt 2197981 ggtttctttt ggctttgttt ctgctttgat gtctgcctgt tcttttctct gtacattgat 2198041 tgccgctgtt tttcgcggtt tcacagtaat tttaaaatca tccggcttga tcgttaatgc 2198101 ttctttgatt tttagttcgt agccagtatg gtttatcaat tcaaaatgct ttaatacaag 2198161 accgagaacc attgtcgctt cttgaagagc aaactgcatg ccaatacaag cgcgctgtcc 2198221 gtttccaaac ggcttatacg catggtgagg gatacttgaa ggatcctcaa accgttccgg 2198281 acggaaatct tccgcatccg gtccccaagc gttttgatcc cggtgcagtt ttggaattaa 2198341 aacagtgact ggctgccctt tgctgatcgg atattccccg cctagaacag tatcctcctt 2198401 cgcatataga gaaaaagccg gagctgttgg atacagtctg agggtttcat ttaaaaccat 2198461 ccgaatgtat ttgagctgct ggatttgttt atattcaggc gtgtcatccg ttaacacgcg 2198521 atccgcttcc tcctgagctt ttttcagttt ttccggatgt gtaagcagac aataaatcgc 2198581 aaaggatagc aacccgcttg ttgtctcatg tccagcaatt aaaaatgtga tgatttggta 2198641 tcgaatgttt tcgtcatcca gcgtttcacc cgttactgga tctttggcat aaagcatgag 2198701 agacaagaga tccttaatgt tttcatccgg attcgccttt cgctccgcta tcattctatc 2198761 aaccagggag ttcatgactt ctatatcctt ttggaactgc agcttcgttt tcaccatcat 2198821 tttatcttgc aggcccagtc ttttcgattg attcatcgcc tcttttaagg cacggagcat 2198881 actggtgata aacggatgct gtgaatcacg gtaaaagctg ttgaatcgat agttaaaccc 2198941 gcataaccca atcgtatcaa gcgtcagacg tgtcatatcg tccgctacat caatttcttc 2199001 attagggttt aaccggctcc acttttgaat cagctgggtt gcgatatcca gcatcataga 2199061 atgatagcct ttcatcgctt tttgactaaa actcggcagc aaaatgcggt gggctttttg 2199121 ccagttcggt tcgtgcgtcc agcttgtaaa taagccatct cccccgaact cacgcacctt 2199181 ttgcaagcct ttgccaaggt tcttgtcaaa gcgtttttca tcacacactt cagccacaag 2199241 attgtggccg gacacaaaaa cactggatac tcccggaaaa tcaaaacgga aaatcggtcc 2199301 caattcatca gctatccgcc ataaggattg agaaagctgt tctttttcca gatgcggaag 2199361 attttttaaa ggtccgtatg ttttgggctg aggtattgcg cttgcctgtt tcattaacat 2199421 ctccctttcc tatttttgtg atgaatgaag cttaatggcg tcccagcagc attgttccaa 2199481 ttcagtaatt aaatcagtgt ccatctctat atcacctgtt tgaacgagct gatatatctt 2199541 gagaaacgcc cctaatacaa tcgcaattaa cacattagag ggcaggctgc gaatcacgcc 2199601 ttccgctttt cccttattaa aatagtcatc aagcatttga gtcagatttt ctatcatttt 2199661 tttgcttgta tgatttaagt aatgagcgtc ttttttggtt tcaagaaaaa aaagcgcata 2199721 gtcgctctct ttcgtaaact gaacgagaca gcaaaatacg tggtgaaagc cttctctgac 2199781 aggcaattct gaaacgtctt gcttcagttt ttccgtaaat cgctggatgc tttcttgaaa 2199841 cagtacgtta acgagtgttt ctttgctgtc aaaataacga tagatcgttc ctgtccctac 2199901 atgagcacgt tcagctatca taggaatagt ggtagcgtca aaaccccttt ccgtaaaaag 2199961 tgagactgac gctttcataa tcatgtcgta tttactgctg gatgcggata tcatgtaatc 2200021 tgacaacctc cgattcgttt acggaatgaa tattcattcc ttttgttcac aaagaatgtc 2200081 tgccctgtct gatatcacct ctttgttctt tcttctgtta taagtttata tgaaaaaaac 2200141 tttttttaat ataaagtata tgcaaaaaat aaaaaattaa gaaaatatac ccaaatccta 2200201 atacgaggat cttggatata tttcccgaga aattttttat ttaacagcca caatacatag 2200261 acaggaagca cgcctgataa cagaaagatc cctgaaatgc tggtctttca gcagttgaat 2200321 atacgttttc tctttttcac cggtatttgt gtcaatactg atataaaacc ggccgtcaat 2200381 ttgaagcacc ctgtaaattt ctcttaatgc aagcctaata tcggtgcagc tttgaaccgt 2200441 atgtaaagaa aagactttat taaaggtacg gtcatcaaag ggaatgtcct ctggatagcc 2200501 atgaaaaacc tccccgttcc ccatgttctt tcgattcgca cgtgatatct gtcttacctt 2200561 tcgttttgaa ggatcaatgc tttttaggct accctttttt agtttcttgg ttatgctttt 2200621 aaagacagtg ccgtttccaa ttccaatttc taaaattctg tcattttctt gtatatctat 2200681 agagtcaatc atcatatgct caattgtttt ggttagctta tatttccgag aaaataattt 2200741 ccaaaaatcc gatcgtttat agagtctatt ttctagcatt ttaaacacct gcttttggtt 2200801 tcctatgttt atttattatc ttaaaaaaat aaacatcatc ttcatttcta aaagtgaagg 2200861 aaggtaccaa ctagacggca atgtattgaa aaatgtttca atagaactaa actttttcat 2200921 ttttttccga aaaaaaagca gaaaacataa tgttttctgc cctctttcta atgccaatga 2200981 taagggaata catacagcct ttgctgctgc attgccatca gcctctgctg tcggaatgga 2201041 tttccataac catgtttgaa ggaatgcggc atggacgcat aaccatggcc aatcgacggc 2201101 agtctttttt gataatcgtt catcatgcca tcacctgcct cacaataacg ttgatttact 2201161 atatgcaggc gcgcattttc ttgacagcta tttcgctaaa cttggtcctt ctccattgta 2201221 taatgcatca atagttccat tctaagcata tgccattccc ccttcagttt ttttcgttgc 2201281 ttttagcgcc agtttgttaa ataaagatgc tttaactgag actctttcat ttcatcataa 2201341 atttgttcaa tctgctgttc tcgttcgaat tcttccaggc ttttaaaccg ttttttaatc 2201401 gttaacgtta aaaagaatag gttaatcgtc atatcgctca ccccctttca aagtccgcat 2201461 caagcgaaat aacccgcggc acaacccttc tgccgcgggc aaataaaaac cgcagacaaa 2201521 agaagacacc aatgcctcta ctgcctgcgg ggagttgcgt atgtccgact attccgaatt 2201581 taatgcgtgc gataagcatc ggttaaggaa ggacacgaac tcttccacag gctgaataaa 2201641 ccatgaactt ttacatgtgt atcacgtaca ggttgacgtc gttgtctcat tgtcattttg 2201701 gttcagcctc ctttgctttt ttcttacttt gtaagtatat ccaccaaatt ccattttgta 2201761 aacatctttt tctaaaaatg gacggaaatt gtgcaaatca tcgaatggat ttgcccgttg 2201821 gtcatgacac ctgcttcatt tcttttctgg agcggtcttt cttatgatat gcaataaaat 2201881 aaatgagacc gacaaataca gctccgccga tgacattacc gataaaagcc ggaatgatgt 2201941 ttccgatgaa ctgcccccac gtgaatgagc ctgcaaaaat ggcagcagga atcacaaaca 2202001 tgttggcgac aacgtgctga aatccgatag ccacaaaagc catgattggg aaccagatgc 2202061 caaggatttt tcctgctgcg tcttgggcgc cgaaagaaag ccacactgca agacatacaa 2202121 gccagttaca gccgatggcg gaaatgagaa ccttgccaaa gctcatatca agctttcctt 2202181 gggcaacggc aatcgttttt tctaaataag gacctgtttc agtcaatcca accaaatgcc 2202241 cgaaaaagta agcaacaaac aatgcgccga ttaagttcat aattgtgacg attccccagt 2202301 taatcgctaa ctcttttact gatatttttc tcgaaaataa cgccatcgca actgacatca 2202361 tattgcctgt gatcagttca gcgccagcga gaacgacaag gatcaggccg actggaaata 2202421 ctgctgcacc aatcaaactg gacaggctcc cccattcttt cggaagatcg ccaattaccc 2202481 tgatatcaag caaataccca agcgcgataa atgcaccgcc taaaaacccc agcacaagca 2202541 gtgacggcag cgggagcttt atttttttca tccctgcttc aattgctgct tccgctattt 2202601 catccggttt tcgaaaagcc ataataaaac gcctccatta cttcttcttt tctcacagtt 2202661 atgcaagaaa ggcaataaaa aaggcagcac tcaaataacc tgtgtcaaac caggcgtttg 2202721 aatgctgcct aacttgtatg catacccata caacaatatc aagcagtata taagatattg 2202781 aaagagaata tatacagttc gtgcatacat tccattgctt tagccttcta taactgtagc 2202841 aacatcatat caaatgtgac aaatttgtgt caatgacaaa tatactagct ttgcagagct 2202901 tctttttgct catctatttt tcggtcaaaa acaaatacag atacagcgat gttttcctca 2202961 attttaatat cagaaaacaa atggactagc ttagctccca taagttcctc cattccttcc 2203021 ggtgtttgtt tggaataaag gtcttgaatt aggcttgtcc gggccgcatg taccatctct 2203081 cttccttcag gcgtgcgggc aataaactgc tcgcttgcac tcagatttcc gtatagtgtt 2203141 gaaactgcca tgttttctac aaatacagta tgaattctct caggcccttt tccgaacaat 2203201 tctttgcgaa gttttcgaat aatatcattg aattcatgaa tttttttaga catgctgatt 2203261 accccttccg atattgcctt ataaaggctt ttcccggttc ccctcaggac atttcacttg 2203321 gttaaaattt tcctgccata ttgtattata ataaatatca cattataata aaagcagtgt 2203381 tgatggattt gtaataggat cttgttatga gtctatcgtt ttataaaaat caaggattgg 2203441 tctgttagta agacttgcta gtgaactatt ccgccatgtg tgtttacacc ttcttagaat 2203501 taagggcagg tgtatctata catggctttt tttgacttct tgaaagaaag atggagggga 2203561 atatgaatat gatggacgtt aagtcgatca gtgtccgtgt agacggaaca gaaattcaag 2203621 cacgagcagg ggccacaatt ttagatattt taaatgaaaa cggaattgag tacccgcaga 2203681 tttgccacgt accagaggtt gacccgattc aaacttgtga tacttgcata gtagaggcaa 2203741 acggcaagct ggttcgttca tgcgcgacgg ttgcagaaaa cgggatgtct attgatcttt 2203801 caggaaatcg agtgaaagaa gcgcaaaccg aagcgatgga ccgccttctt gaaaatcatt 2203861 tgctgtattg tacagtttgc gataacaaca atggaaactg tacgctgcat aatacagcgg 2203921 aaatgatggg gatcgagcat caaaaatacc catacacgcc aaaagaagat ccttcttgcg 2203981 cggttgatat gtctcatcct ttttaccgct atgatccaaa ccaatgtatt gcctgcggcc 2204041 agtgtgttga ggtctgtcaa aaccttcagg taaatgaaac actctcaatc gactgggaac 2204101 gcgaacgccc tcgcgtcatt tgggatgagg gagttccgat caatgaatct tcctgtgtca 2204161 gctgcggtca gtgtgtaaca gtatgtccat gtaatgcact gatggaaaaa tcaatgctcg 2204221 ggcaggctgg ttttatgaca ggcattaaag aggacgtcat ggaaccgatg attgatctcg 2204281 tgaaaaatgt tgaaccgggg tatggcagca tttttgccat ttctgaagtc gaagcggcaa 2204341 tgcgtgaaac gagaacgaaa aaaacgaaaa ctgtatgtac gttctgcggt gtcggatgtt 2204401 catttgaagt atggacaaaa ggacgggata ttttaaagat ccagcctgtt tctgatgctc 2204461 cggttaacgc aatttccaca tgtgtcaaag ggaaattcgg ctgggatttt gtcaattcaa 2204521 aagagcggat cacaaagcct ttaatccgta aaaacggagc ctttgtggaa tcttcttggg 2204581 aagaagccct cgatcttgtc gcaagcagat taggatcaat taaagagcag tacggtaaag 2204641 gctctgtagg gtttatttct tcttctaaaa ttacgaatga agaaaactac gtcattcaaa 2204701 aactagcgcg tcaggtattt gaaacaaaca acgtcgataa ctgctcacgc tactgccagt 2204761 ctcctgctac agacggattg ttccgcactg tcggcatggg cggtgacgcc ggcacgatta 2204821 aagatattgc caaagcaggc ctggtcatca ttgtcggtgc caatccggcg gaaggacacc 2204881 cagtgctcgc aacacgcgtc aaacgggcac acaagctcca cggtcaaaaa ctgattgttg 2204941 ctgacctgcg taaaaatgag atggctgagc gatctgatct gttcatcagc cctaaacaag 2205001 gcacagacca agtttggctg atggctgtta cgaaatatat gatcgaccaa ggctggcacg 2205061 atcaggcgtt tattgatgag aacgtcaatt actttgaaga ttataaagaa acccttaaaa 2205121 cgtatacgct tgattatgca gaacgcatca caggcctttc aaaagaaaac atcattcaaa 2205181 ttgctgaaat gattcgtgat gctgacggca cttgtgtcct ttggggaatg ggtgtcacac 2205241 aaaatacagg cggttctgat acatcagcag ccatttcaaa cctgcttctc gctacgggca 2205301 actatcgccg tccaggtgcc ggcgcttatc ctctgcgcgg acacaataac gtgcaaggcg 2205361 catgtgatat gggaacattg cctggctggc tgccgggata tcagcatatt acagatgaca 2205421 aagcacgcgc taaatttgaa gaggcatatg gtgtcgagat tgatggaaag cctggtttag 2205481 ataatattca aatgcttcat gccattgaag aaggaaaaat gaaagctatg tatcttgtcg 2205541 gtgaggatat ggcactggtc gattcaaacg cgaaccatgt gcatgatatt ttatcaagcc 2205601 ttgatttctt cgtggtacag gacatcttcc tgtcaagaac agctcaatat gctgatgtcg 2205661 tcttgccggc cactccttca cttgaaaaag acggaacatt taccaacaca gaacgccgtg 2205721 tccagcgatt gtatcaggcg cttccgacgc ttggtgacgc aaaaccggac tggtggatta 2205781 ttcaagaggt ggcaaaccgt ttaggagcga attggaatta cagccatcca agtgacattt 2205841 tctctgaaat ggcgagtctt tctcctctgt ttgccaaagc aagctatgag gtgcttgaag 2205901 gctggaacag cttcctatgg ggcagcttca caggtgaaag cacaccgctt ctgtatgaag 2205961 acggatttaa tttccctgac aaaaaagccc gctttgccct ttctgattgg accgagccag 2206021 cggcatttcc ggaggaatat gaccttcata tcaataacgg ccggatgctg gagcatttcc 2206081 acgaaggaaa catgacaaat aaatcgaaag gcatccaagc gaaagtgccg aatgtattcg 2206141 ttgagatctc acctgagctt gcacaagagc gaggtgtttg tgacggttcg cttgtacggc 2206201 tcgtttctcc gttcggagca gtcaaattga acgcgctgat cacagaccgg gtacggaaaa 2206261 atgaactcta tttgccaatg aactcgacag acaaggagtc agcgattaac ttcttgacgg 2206321 gccctgcagc tgataaacgg acgaacacgc ctgcttataa acagacaaag gtccgcatgg 2206381 aagtgcttgg cggctgtgaa acagcgccgc ttccaaaaac aaatccgcgc aacaaaaaac 2206441 ggcatccgca aaacggagtc gaagcagaaa gaaaatggaa ccgccctggc tatgtacatc 2206501 tgactgatta aacgatagga ggaaaacgaa tggccactcc gattacgacg atcaaaaaag 2206561 aaacaaaaac agctgagcaa attaagcttg aaaaaataga agaactgaaa gagctgctgg 2206621 cggaaaatga ggacgccgtc tctaaaacga tgacgttaat gaatgaactc aatgatcttg 2206681 gaatttttga tgcggcaaca agcatgctca gagcgaagga agacattgcc aagattgcgc 2206741 ttggccaagt ttcccgcgag cctgtcacca acctcatcaa cacgatgatg gccgccggag 2206801 gcgcattgac aaaagccgat cctgagttta cagcaaagct tttagaaagc gtaatggctg 2206861 ggactgaaca ggcacaaagc tttttaaaag aagacaagaa agtcgggatt ctcgacctgt 2206921 taaaagcaat gaacgatcct gacatcaaca gagccgtcgg gttcggcctt cagtttttaa 2206981 aaggcatggg aaaagaactt cgagaacaat aacagaaaaa cagccatctc tgatgatggc 2207041 tgttttttta ttcgtcggct tcttccagac gcttcttgta aataagtgaa cggtcagcgc 2207101 aaaagaaggc accggctaaa aatacgcaat ccgctaaaaa catcgtcgat ttctggccta 2207161 atgttaagcc ttgatcaggg agaactgcgc ctatatataa aaaagtgctg actgcaagca 2207221 atgtaaaagc aaaatgcttg tagtcttctt ttaaagattt cattctattt ttgttcaaaa 2207281 gaatcacctg ccagattcat agtatacgac tattataata taatccggcg gcttacagag 2207341 aaagtaattc tatccatttg ttatatattt tcaagcgctt ggccgatatc ttccaacaag 2207401 tcttccgcat cttcaattcc tacagaaatt ctgatcaagc cgtccgtaat gccgagctca 2207461 agccggcgtt ctctcggaat agaggcatgt gtcattcttg caggaacaga aattaagctt 2207521 tcaaccgccc ccaggctttc agcaatggta aacagtttca gatttcctaa aaacgcatca 2207581 acccgttctt cactgccaat atcaaaggag atcatgccgc cgaagcccgc tccttgcgtt 2207641 tttgcaagct catgtccggg atgatttgaa gaaccagggt aatataacgt ttggacagca 2207701 gggtgattct caagaaagct tgcgattttc cgcgcatttt gatcgatcgc ttccattctg 2207761 agtcccaacg ttttgattcc tctcattaac agccaggaat cttgagggcc gagcacgccg 2207821 cctgtggagt tttgcacaaa atgcagctct tctccaagct ctttcgaagc tgtcacaact 2207881 aaacctccga cgacatcact gtgtccgcca agatattttg tcgcactgtg cagtacgata 2207941 tcagcgccta aagtaagcgg ctgttgaaaa taaggagtat taaaggtatt gtctacgata 2208001 agcagaacac ccgctttttt tgcgatatca gccatgagcg tcaggtcggt gattttgagc 2208061 aacgggtttg tcggtgtttc aatataaatt gcttttgtat tagggcgaat cgctttttca 2208121 acttcttccc tgctgctcgt atcaacaaat gttgattcaa tgccaagacg gttaagcacc 2208181 tttgtcatca cgcgatatgt tccgccgtac acatcatcag tcaacacgac atgatctccg 2208241 ctgttaaaca gcatcataac cgctgtaatg gcagccattc ctgagctgaa cgcatagcct 2208301 gcttccccgc tttccagttc tgtcacaagt gcttcgagag cggttcgagt cggattggcc 2208361 gttcttgaat actcgtagcc tgtatgctgc cctgctttcg gctgcttgta cgtgcttact 2208421 tgataaatcg gcacggaaac tgcgcctgtt ttctcatcac ctgtgattcc gccatgtatc 2208481 atcaatgttt ttttcttcat atcagatgcc tccttcgtat atttgtttgc tgatatatcg 2208541 atcgctgctg tcaggaaata ctgtgacaat gttagttcca gcggatgctt ttttcgcttc 2208601 ctccaatgcc gcataaagcg ctgcacctga agagcttccg atcagcaggc cttctttttc 2208661 tgccgcttct ttcacaagtc taaacgcatt ctcatctgtt acggtgtaga tctcgtcaaa 2208721 atggctctta tccatataat cggggataaa ctccatgccg atgccctctg ttttatgagc 2208781 gtggggctct cctccgttta aaatcgagcc caccggttca acaatcaccg ttttgactgc 2208841 tggatttttt tcttttaaga aggaagctgt ccctgcgaat gtgcctcctg atcctgcccc 2208901 tgcgacaaat gtatgaatat tcccgtcaag cgcttcccac atttcaggtc caagcgtctt 2208961 atagtaagtc gatggattta ctcggttttt aaattgcaaa acgcaataag aattttcaat 2209021 ttcagtctcc agctgaatgg ctttttgaat ggctccctgc attccgtctt gacgcggtgt 2209081 atgaatgatt gatgcgccaa gcgcttgcat aatttgctgt ttctctctgc tgaaatgttc 2209141 agggacacag aaaatcgctt tcagcccata ttttctggca cttaacgcaa ggccgatccc 2209201 tgtattgcct gccgtagctt ctataatcac tccgccgggt ttcactttgc ctgaatcgag 2209261 cgcgtcacga atcagcatat ctcccagtct gtctttgatg cttccccctg gattcatcat 2209321 ttcaagcttg gcatacaccg cgactccttc tggaacatca aagttcttca agcggagaag 2209381 cggtgtattc ccaatcagct cggtaatgtc cgtaatcact gtcatatatg tcctcctcct 2209441 taatagaggt tgtttttaga gaaaaacgga ggagaacgtt ctccccgttt taatgaattc 2209501 gtttgatcac ctttaacaca agctctgttg aatgaacagc cgcctgctct aaaaattggt 2209561 caaatgaaac atgtgattct ttgcctgcga tatctgataa cgctctgatg acgacaaacg 2209621 gcgttttaaa ttgatggcat acttgagcca ctgccgcagc ctccatttca accgcgtaca 2209681 gatcagaaaa tctcgcacgc acctcttcaa cccgcttcgg atcgttcatg aaagaatcgc 2209741 ctgttgcaat cgttcctttt gcaacctgaa tgccgtcgag ttcagatacc gcttcttcag 2209801 tgatgctgat cagcttttca tccgccgcat aagcagccgg aagacccggc acttggccgt 2209861 attcatagtc aaaagccgtt acgtctacat catggtggcg aacgtcagtg gaaatgacga 2209921 catcccctac attcaatgta tgatgaaatc cgccggctga gcctgtgtta atgacataat 2209981 caggcttgta acggtcaagc agaagcgtcg tgctgatagc agcatttact tttccaattc 2210041 ctgattttaa aagaatcact tcagttcctt catattcgcc tgttgtaaat tcacagtgtg 2210101 cgatcgtttc tgtttttgca ttttcaagtt tgtttcttaa gatggtaact tcctcttcca 2210161 ttgctccgat gactgctagt ctcatctatt cacattccct tcactttacc gtttgatcgc 2210221 ctccattatc cacacgaagt cgttttgctg agtgaatcgg actgcaaaac cttcagctgt 2210281 aaacatttct ttcaacgcat ccaatgtagg ataatgctct gtctctaaat catttgcaag 2210341 ctgataaaag ccttgagaac gggctttatc gatagcctgt tgatacgctt gcgcattttc 2210401 aaagacggta tcggcaaaca ctattttatc atgcaagtga aggtatttgc catattgctt 2210461 tatggcagcc cgcttttctt cgtcagtcaa atgatgaaaa gcatatgaac tgacaatcgt 2210521 atcagcctga aatggcggct cagggaatgt caggaagtct ccatcaacga tttccgtcct 2210581 gcctgagagc ttgtcagaag ccagtttacg cattgctgga gaaggttcga ttccaaatac 2210641 agttttgcct gcatcgagca gcttagctgt caaattcccg gtccccgggc caaattctaa 2210701 cacatgcgtt ccagattttc tgacgatggc atcaaggata tgatcgtagc ctctgaacgc 2210761 ttctttatac tgaatatcta aaccttgtac tgtttgatca taagttgctg cccaatcttc 2210821 aaagagaggg ataaattcac ggcccatatt tgtcacactc catatttaat aattcctata 2210881 agtatactat ggattaatga tggaacagtt cctataatac cacatattct gaaaagcagg 2210941 tactaaaaca ctttgtgtat tttatgccat ctcatattgc gcattgaccg caaaaaagct 2211001 tatacttcat atgacttgtg aaagctggag ggtcaagaca tgaattttca attagatctg 2211061 attaaagaca aagtggaatt ttttgaagcg gcttcattgc aggagcttga aaagaaaatc 2211121 aatacacaaa ttgaaaacaa taaagccatc atgctccggg tgaaatctgt ttcacaccaa 2211181 actcttgtgg cagaaggaag aatattgtac agcgcggtgg ttcatttctc agctgaagcc 2211241 taaaacaaaa gcagccggtt ttaacccggc tgcttttgtt tattttagct tttctacttt 2211301 tgtcggcttc cagccttttt catcgaccca tgtaatcgtg acttgatatt tattcccagt 2211361 cgccttgtcc aaaatcttgc ctttggcatc ctgagggctg ccgttatttc caagccagag 2211421 caccgtcatg ttatctgttg agacaccagt tgcgtacgaa atggctttca gcatctcagc 2211481 ccagtcttgt gagcttgaat cataagtagc ggcatgctcg ccagtctgct cagttccgac 2211541 tgctttccag tcaggatttt catacgtttt ttccacatcg ctcgatgagc cgccttctgt 2211601 tacttttgca tctttaagcc cgtcaccggc tgaatctgag cttgaatctg aatcagagtc 2211661 atctttttta gaagaagaat catctttttt ggaatcagag tcagaagact tctcagaatc 2211721 cttttcgctg tcagatgtat ctttcttgct gtcttttata tcctcatccg atttcttttc 2211781 cgtctttcct gaagccggag attcctgttt ttgcgccgtt tcagaatcct tgctgacatc 2211841 tttgctagaa ggactgttaa tgaagagatt cgctgctact acgacaatta gtatggatac 2211901 gattgcgatt aaaatgttaa gcactaaatt ggcttttctg cgtttatcac gattttcata 2211961 acgagattga ttattgctca ataattctgc actcctttat ccctcttggc tcagcatata 2212021 ttttaacatg tgctgagaag ttgttctatt tctgattgat ttcaatttcg tgtacttttt 2212081 taacaatatc ataaaacacc gaatttgtca gagccttatc tcccggtgta tccatgtgta 2212141 aaacaactag agcgtatttc ggcttatccg cgggaaaata tccggcaaac catttttcgt 2212201 agagcgtttc cttctctttt gaaagcttgc ctgtctgggc tgtgcccgac ttccctgcta 2212261 cagtatacgg aagatcttga aaccttctgc ccgttccgga aggagattct actacccgcc 2212321 gcagtatttt ttgaagctgc tgtgacgtat atttgtctat cgtttcccct ttgagcttct 2212381 gatctttaaa cgtaacgagc gttgtgccgt tcttatactc aatttgttcg gcaattttca 2212441 cctgccgttt ttctccgccg cgggcgattg tcgccatcat attggctacc tccagcggcg 2212501 ttacctttac atttttctgc ccgattgctg tttgcgcaat ggcttttttg actgatttgt 2212561 ctttttcatc cccccaaatc acgccgcttt tttcgttata cagctggcgg aaatcggttt 2212621 cgtggtacag ttttccctcc cagcctgccc gatcagtgag agccagcttc tcggacatat 2212681 cttcaataac cgagctgtct tttttcatta attgttctgc aagactcgta aatgtgtaat 2212741 tacagctttg ggcaaaactt tcatcaaaag acaaggtgcc tttgtcgtcc cccggttccc 2212801 cgtacaggtt taaattgcaa ttaaaggttt gactaggctt caccatatta ttttcgattg 2212861 cagctgcggc aatgactgtt ttaaaaactg atccgggata gattggcgtc agcatataat 2212921 tttgaagtgt gttttgccgg gacacgtctg catctggttt gcttacaatt cccagaacac 2212981 tgctattttc gatgtccagc agcacagctc ctcccttttt cagcccctgt tcatccaata 2213041 cctcctccat cgctttttga atgctttgat cgatcgttgt tttgatctgg agcggataaa 2213101 atgtattggc ttcagctgta tatttgacgt ccatgccaaa caaagggttt ccttttccgt 2213161 ccacatgata taaaagcttt gtgtcttgtt ccggaagcaa aaactcgtca aatgtccgtt 2213221 ctaaaccggt tgttccgatt tctgttgtaa tcggaaggct ctccttgtca ggatatttct 2213281 tgcgaagcag cgccggatct tggttcgtgc tccctatcgt atgtgaagca aggctgggct 2213341 tgtcttcatt ctccatatat acgccgtaaa tgccgggata tttcaaagaa ttgatttttg 2213401 tgatagattg ttttgaaagt gttttgattt tcttttgctg caaaatgacc ggtttttttg 2213461 cctgacctag tgtctggcgc aaatcatctt cagacatgcc gaggatgtcc gcaacttttt 2213521 tgatcggcca atcctgcgtc agcagaaaag ggaacaaaac aaccgcaggc tcgctttgtc 2213581 ctgtcagcgc ccgcccgttt cgatctaaaa aagagcctct tccatctgaa atgagcactt 2213641 cctccgtccg ctgtttcaca ctttcttgaa tcaaattaat tttcttttta gaaaatgatt 2213701 ctgtgaaaaa cagctggatt tctgcaagtc tcagcagaag cagaaaaaat acaatcaaaa 2213761 aagcgatgac tgccagcttc attcgtttcg atatcttcat aaaaaaacac ctcacccaca 2213821 ttgtggacga ggtgtttcgc tgctaaacag atattatgaa attttcacaa ttttcacgag 2213881 catttctccg cccggtgttt gtactgtgac ttcttcatct acttttttgc ccaagaggct 2213941 ttttgcgatc ggtgaatcgt ttgagatttt cccttcaaac gggtcagctt ccgcgcttcc 2214001 gacgatcgta tatgattctt catcaccgtc aggcagttcg acgaaagtga cggttttacc 2214061 caaaccgaca acgttagagc cgccgtcatc ttcaatgatt ttcgcattgc gaatcatatt 2214121 ttcaagagtc gtcacgcggc cctctacaaa tgcctgctct tctttcgctg aatcgtattc 2214181 agagttctcg gaaaggtctc cgaagcttct cgcaattttg attcgctcta ctacttcttt 2214241 tcgtttaacc gttttcaaat attctaattc ttgttcaagt ttttgttttc cttctgcagt 2214301 cataggaaaa actttctctt gtgccatgtc ccttcactcc ttctggttgt ccctcaacat 2214361 cttcgattat gtatgagagc ataaactaaa aaatacaaga atgagaacac agggcagtcc 2214421 tcgttcttct ctcccatata ggtactgttt atcttaaact gaatcgtgtc gttctgcaaa 2214481 tatttcgcgt ttataaacag ggaaagaagg gaattcgcac attcccttcc tgcctataca 2214541 taatatggtc agagttattt atgtctatgc tatggtatta caaaatcgcg ttttgttcaa 2214601 gaatggtttg aatttttgtg accatcagat caattgcgac gtgattctga ccgccttccg 2214661 ggataataat atcagcgtat cgtttcgtcg gctcgacgaa ttggttatgc atcggacgga 2214721 ccactgacac atattgttca atgacagaat caatagagcg tccgcgctca ttaatatctc 2214781 tcataatccg tctgatgata cgcaagtcag cgtccgtatc aacataaagc ttgatatcca 2214841 tcagatcacg aagccttttg tcttcaagaa caagaatgcc ttcaaggata ataacatcct 2214901 ttggctctac gtgaaccgtt tcttctgaac gtgtgtgaag cttatagtca taaatcggct 2214961 tttcaatcgg gcggtaattc aatagatctt gaatatgctc gattaaatag tcattatcaa 2215021 acgcaagcgg atgatcatag tttgtgttca gcctttcttc aaacggaaga tggctttggt 2215081 ctttataata aaggtcctgc tggatcatta aaattgagtg tcctttaaac tgttcataaa 2215141 tggaccgtgt gacactcgtt tttcctgaac cggaacctcc tgcgattcca atgactactg 2215201 gattcttacc catgggctgt tacttcccct ttctcatcat gttgctcgga taaatctttt 2215261 tgtctagttt gaatttgaca atttgcaggg gatggcgggc agcatctagc tcatttccgt 2215321 cttcgtccca aatggtttca atcgtatgtg taaagttttc gatttctgga ccgaaaaatt 2215381 ccacttcgtc gccttttttg aagaaattgc gctgctgaag cgtgaccatt tgtgtatctt 2215441 catcataatt cagcactaag ccgacaaaat catatgtcgt tttcttggcg tgttcgccga 2215501 acatttgctc ttcatagcct ggcgttcctt caaagaaagc tgtcgcagtg tccctgttgg 2215561 cgcacttatc aagctcttca agccattctt tttgaatcac aaagttttct ggatcagcgc 2215621 aataagcatc gattactttg cggtatacgc tgacaacagt tgctacatag tgaatggatt 2215681 tcatgcggcc ttcaatcttt aagctgtcga tccccatttc aatcattttt ggaatggatt 2215741 caatcagctt caaatctttc gggctcatcg caaatggtgc atcttcttca ccatacaaag 2215801 caacggcgtt ggcaccgtct gtttggtaga gatcataatc ccagcggcat gactggcagc 2215861 agcctccgcg gttggaatcc cgcgctgtca tgtgattgct cagcacgcag cggccggaat 2215921 atgcaataca cattgcgcca tgaatgaagg attcgatttc gatatctacc ttttctttca 2215981 tttctctgat ttcaagagcg ctagtttcac gtgccagcac gacgcggtcg agaccttctt 2216041 ccttccagaa ctggacagcc ttccagtttg aaagagactg ctgtgtgctc aagtgaacct 2216101 caacattcgg cgccactctg cggcatgttt caataataag cggatctgcc acaataatac 2216161 cggcaacgtt ggcgtctcca agcgctttta aatagtcttc aagcccgtcc atgttttcat 2216221 tatgagcgaa aatattcgtt gttacgtaga tcttcgcgcc atatttcttt gcgaattcaa 2216281 cgccttctgc aatttcttcg atcgtaaagt tatcggcatt cgagcgaagc ccgtattcct 2216341 gtcccccgat aaagaccgcg tccgctccgt aatgaacagc gattttcagc ttttcaagat 2216401 tacccgcagg tgcgagaagc tccggctttt tcgtaatcac acgctttcca ttaacgattg 2216461 tggatatttt atcatttacg gcagtcatag cttaacctcc ttttgattaa taaaccgttt 2216521 ccttgaagaa gaatccggta tcaatttttc tgtttactgg ctggatgctt tcaatgcgtt 2216581 cgatccagtc ttcttttttc gcttcgtatt cgtcacggtt ttccacgcac aaatcaattg 2216641 cttctctgta cattttggtg acttctatta ggtattcagg cattttcaaa acaccatcga 2216701 ttttgaaaga atcaattccg gcatctatca attcctcgag ctcatcaatg atgcacacat 2216761 cgttcgggct catgatgtga gtgccgtttt catcttcgaa aatcggatat ttattatcgc 2216821 gttctttatc gtgtaaaaac atgcctgatt cttttttctt tctttcaatg tccatgactt 2216881 tgccctgata ttcaaaatag tttccaatca aagaacgctt cgattggaac atgcacgtca 2216941 ttccatgcac ctggatttca atttcgactt cagcattttc tttaatctca acaatgctgt 2217001 ccatgtttaa ttctctggca agcacagaac gcgccgcacc cttgcgtccc cagtagttgc 2217061 atgtataata gttggtgcct gtcgtttctg tgctccaatg aagcttcaga tcaggcgcag 2217121 attcacgggc agccatcagc acggcaggat cgccgaatac cgctgcatcg acaccggctt 2217181 ctgctaagaa agccagatat tcgccaagct cacccacttt atcattatgg aaaattgcat 2217241 ttacagcaac gtatactttt gccccttctt tgtgagcaat ctctacggct tttgttacat 2217301 cttcacgaga aaattctccg gctaatctca agccgtatct ctgttcccca actaaaaacg 2217361 cagttgcccc agcctgtatg agcggcaaaa tgtccgctgt actcgtcggc gtcactaaga 2217421 gctctggttt tttcatgacg ttcacctctt ctttttacta atcgcaagtc cgtccccgac 2217481 aggaataatc gcagtttgat aatccggatg attcatcagc caatgattat attcatcaat 2217541 tttggctaca agcctgcgcc ttctcttcgg ttctattttg ctgtaatcct ctgccaccag 2217601 acctttaaac agcacgttgt ctgttataat caccccgtcc ggtgaaagca tcggttcata 2217661 taaatgaaaa aagttttgat actgaccttt tgcagcgtca ataaaaatga catcgtaagg 2217721 cgcggttaca tgaacggcgt cggctaattc aagcgcatct ccgtaaaaaa catgaatccg 2217781 gtcatcaagc tgaaattcct tgatattgtt taccgcttct tcatgccgtt tctcattgcg 2217841 ttcaattgta tatatttcag cagacggcag ttccagagcc attcgaatgg ctgaataacc 2217901 aatggccgtt ccgatttcta gtattttttt cggctgtttc acagacaaaa tttgaagcag 2217961 cacctccatg cccgcttttt ccataatcgg gacatgatgt tcttctgcat atgcttcaag 2218021 tctcttcacg ttatccggcc gaggctttaa taatgcttct atatagtcat ttatttgttc 2218081 ataccggtca gtcactacaa acagcctccc gttctaaaaa ggagtgcccc agtcttatgc 2218141 gcaggacact ctctgaatac atcatgatac atcggtaaac aacccgatat attttatcat 2218201 aaaaccttgc ggaaagcgaa caaaaggaga gctttttgct ctccttttat ttctcatttt 2218261 ttgaggaaat gtatttttct tttgctttat tatgctcttt tagcgttttt gtaaatacga 2218321 cctcaccatt tgatttggcc aagaaataca gatagtccgt tttatccgga tgcagcgctg 2218381 cttcccatga tgacatgccg gcattggcaa tcggccctgg cgtcagccct gtgtttttat 2218441 acgtattgta tggtgaatcg atttccagat ccttataaag aacccgatct ttatgcttgc 2218501 ctgccgcgta caggacggtc ggatctgttt ggagcggcat tttctttttc aggcggttat 2218561 aaaagacgct cgcaatttta tggcggtcgg ctttttcagt cgcttcttct tctatcaaag 2218621 aagccattgt cagcagctta tgcacagaaa ctttgttttt cttcatttct gatttatatg 2218681 tttccacata agaatttgtc tgcttaatca ttgccttgat aatgtcttca agtgatgtgt 2218741 ccggatcgtt aaaagggtat gtagccggga ataggtaccc ttcaagcggg tgcttaatgt 2218801 ttttattgaa aacatcattt gtcacagtgt ccgggaattc tttcttcagc tgattgataa 2218861 atgtttcatc gtccagcttc gctatgactt gttttttaga gtattttgtt tcatcagcaa 2218921 tagcagccgc gatttgggtc agctgtgctc cctcagtcac tgtgatttga aaagcgtaac 2218981 ctgtagcccc gcttgtcagc ttctgaataa tggcatctaa atccatacct ttattcagat 2219041 ggtagaatcc ggcctgaaac ccggaagcac ctttatattt cacatagtac tgaaacgcct 2219101 tctcgctttt tatgacatca tttttcttta atatcgatgc gatggctgaa acagacgaac 2219161 cgctcggaat gttaatatta actgtcgttt tactgtcttt ttcaacaggt tcaagcaatg 2219221 atttcccata taaaaatgcc ccgccaatga tgagaaacag cacaacaatg gaagacagta 2219281 tgattctttt tttattaaaa aacgattttt tttgctgatt gatatacatt aggtctcctc 2219341 ccatcagctc ttatactaca tgattcattg tatttcggca atttattaca aaaagaggcc 2219401 tgcataaagc agaaaaaagc cggagcagta tagctccggc tttggtttgg cgcgatgttt 2219461 tactcttcgt cttcgtccgc taagaatgtg tttagtgttt cttcgatcat atcccattct 2219521 tcgtcagttt caatcgggaa tagctcaccg ttttcaccgt cttcgtttgg cgtgaagctg 2219581 gaagcaagaa tttctacttc ttcgtcatct tttgattcga ttggatagta caagacataa 2219641 gatttgccaa actcttcatt ttcaaatgta aacagcactt cacaaagctg ttcatttcct 2219701 tgatcgtcaa caattgtaat atttttttcg ccgtgttcca ttttcttcac ctctggcttt 2219761 aatttaagct gtcaagatat ccttgtaaaa tcataacagc cgccatttta tcaatgactt 2219821 tttttcgttt ttgcctgctg acgtcagctg caatcagcat tttttcagcc gccattgtgg 2219881 taagacgctc gtcccacagc acaacaggaa cattgtacgt tgtttcaagc actttcgcaa 2219941 atgtttggct ggcttcgcct ctcgggccga ctgttccgtt catgttctta ggaaagccga 2220001 gcacgatttt atctatagta tagtccttta tcagttcaga taaacgggat aaaccataat 2220061 cgccttctgc ttcatttatc tttatggtct caatgccttg agcagtccag cccatttcat 2220121 cgctcagagc tacaccgagt gttttggttc ctaaatcgag tcctaatatt ctcattcttt 2220181 atttacgcct ctttatgctg ttctaaataa gactttacca attcctcgat taattcgtct 2220241 ctttcaagtt tgcgaattaa attgcgagcg tcacgatgcc taggaatata agcgggatca 2220301 cctgacagca agtatccgac aatctggttg attggattgt agcccttttc ctgaagcgcg 2220361 tcatacactg taatcagcac ctcatttacg ttagtctcag cagaatcatc ggagaaatta 2220421 aatttcatcg ttttatcaaa cgagctcacc gttttgcacc tctttcccaa attcgcaggc 2220481 aaagttcagc ctggggtcct aatcttacca tcattctaca ctacatgggc gaattataaa 2220541 acggatttca cccaatcttc tacagaagcc aaagcttctt ctaatttttc cggctgttta 2220601 ccgcctgcct gcgccatgtc cggacggcct ccgccgcctc cgccgcaaac ttccgcagct 2220661 tgtttaacca gcttgccggc gtgaagtcct ttctcaatga ggtcctttgt gactccggca 2220721 gagatattaa ctttatcgtt ttgtaccgca ccaagcacga tcaccgcaga gccaagcttt 2220781 gctttgagtt catcgaccat agtgcggaga tgattcatgt cttttgcatt tacttttgcc 2220841 gcaagcacgt ttacgccgtc aacttctttt actttcgaca ggattgctcc tgcttccacg 2220901 ttgcctagtt ttgcaagaag agattcattt tctctttgtg catccttcag ttcagcctgc 2220961 agagccgcga cccgtttcgg cacttctttg atatttgttt tcagctcgtc agcggtctgc 2221021 ttcaatacag aaatctggct gttcatttcg acgtaagcgc cttgtcccgt tacagcttca 2221081 atccgtcttg tgcctgctcc gattccggat tcagaaacga ttttaaacaa gccgatttct 2221141 gctgtatttc tgacgtggca gccgccgcac agctctaagc tgtaatctcc aacttgaacg 2221201 acacggacaa tatcgccata tttttcgccg aacagtgcca tcgcacccat ttcttttgct 2221261 tcagcgatcg gtttcaaatc aatgctgacc gggatgctcg cccagatctt ttcgtttacg 2221321 attctttcaa tttgttcgag ctcttctttt gtcacttggc caaagtgcga gaagtcaaaa 2221381 cgaaggcggt tttccgttac aagagagccc gcctgattga catgagttcc aagaacatct 2221441 tttagagcct gatgcaataa atgcgttgcc gtgtggtttt taatgacgcc gcttctcata 2221501 tggtcttcaa cttcagccgt aacatgcagg cctttttgaa cagtaccgct ctccacaaca 2221561 ccttcatgca catgctggcc gttcggcgct ttttgaacat ctttaattct tacaactgcc 2221621 tgctcgcttc ggagatagcc tttgtcgccg atttggccgc cgctttctgc atagaacggt 2221681 gtttcatcaa gaatgatttg aacgctttct ccttcatgag cctcttcgat taattggccg 2221741 tcctgaagaa gcacaatgat attggcatca gctttggttt gagagtagcc gacaaatgtg 2221801 ctttcaactg tcacgtcgcg cagtgcgccg ccctgcacct gcatgctgcc gacatcctgg 2221861 cgggcgtttc ttgcccgttc acgctgctgg ttcatttcct cctcaaagcc ctcatggtca 2221921 accgtcatgt tctcgtcttc tgcgtattct tcagtcaatt caaccgggaa tccatacgta 2221981 tcatacagtt taaacacatc agcacctgag ataacgctgc tgcccttgtc tttttctttt 2222041 ttgatcattt ctgacaggat cgcaagccct tcattaaggg tctcatggaa gcgttcttcc 2222101 tcggttttaa tgacttttgc gatgaaatcc gctttctctt tcacttcagg atagaaatca 2222161 gccatgattt ctgcgacaac cggcactaaa tcaaacatga acggacgatg gatgttgatc 2222221 gttttggcat aacgcacggc acggcgtaat aagcgtctta atacatagcc gcggccttca 2222281 tttgacggca gcgcaccgtc actgacagca aaggcaaccg ttctgatatg gtcagcaatc 2222341 actttaaacg cagtgtcttt cacattgtct ttgccatatg tttcaccaga aatcgattct 2222401 gttgctttaa tgatcggaac aaacaaatcg gtgtcaaagt ttgtcggaac attctggatg 2222461 acagacacca ttctttcaag acccatgcct gtatcaatat ttttctttgg aagcggtgtg 2222521 tacgtgccgt cagggttatg gttgaactct gagaacacaa ggttccatac ttccaggtaa 2222581 cggtcgtttt ccccgcctgg gtaaagctcc ggatcttctg gatcattacc gtatgcttca 2222641 ccgcggtcgt aaaagatttc cgtattcggt ccgctcggcc cttcaccgat atcccagaag 2222701 ttcccttcca gacggataat tctttcttca ggaataccga tttttttcgc ccaaaactca 2222761 tatgcctctt catcttcagg atgaaccgta acagagagaa gctctttgtc gaagccaatc 2222821 cacttgtcgc tcgttaaaaa ctcccaagcc catgtaatgg cttcttcttt gaaataatcg 2222881 ccgatggaaa agtttccgag catttcaaag aaagtgtgat ggcgcgcagt tttacctaca 2222941 ttttctatat cgtttgttct gatcgctttt tgagcgttta cgattcttgg attttccggc 2223001 acgacacggc cgtcaaaata ttttttcagc gtcgcaacac cgctgttgat ccaaagcagt 2223061 gaaggatcct catgaggcac taatgacgcg cttggctcta ccgcatgtcc tttttcttta 2223121 aagaaatcca aaaacatttg acgcacttcc gcagaagtta agtgtttcat tgtatttcct 2223181 cctctataaa aatcgaaatt ctcttcagtg acagcaaaaa agccctcccc ctatgcaaac 2223241 caacgtttac acagggacga gagctgtctc gcggtaccac cctgattacg ggcattcatg 2223301 cgcccgtcac ctttaaccct gtaacgcagg ataagcggca gtgattaact gcactcagga 2223361 ttagcttcct ccgatcttct gataaagctc ctttcagctt atggagcttc tctctttaac 2223421 agggcttcgg cgtactcaga tccgtcactc gagattcgta tgtattctac gagaaattat 2223481 agacaagcgg cacgccgatg tcaatgctcc gtcctcatcc gcaaaaaatg gatcatcatt 2223541 acttttaaaa cagccgtcgc aggaacagcc agaatcatcc cgacgatacc cgcaagctcc 2223601 cctccggcaa ggagtgcaag catgataacg accggatgca ttttaaggct tctgccgaca 2223661 atgaacggac tgaggatatt tccttccata aactgcagaa taaacaccgt aatcaccaca 2223721 acaagaaccg ccttgactga gatcgtcatc gcaattaaca acgcaggaac agctccgatg 2223781 aaagggccaa aatacgggat gacattcgtt accccagaga taaggccaag tatcagcgga 2223841 tacggaagcc caaataccca gaacgaaatg cctgcaatca cgccaagaat caagcagacc 2223901 aaaagctggc cgcggatata atcgccaagc gaatcatcca catcccgcaa aaaggcgctg 2223961 ccccgctttc tccacgactt cggagtcaag taccatactg tctttttcat taactcaatg 2224021 tccttcacca tataaaacac gagaaaaggg attgttgcag caattaagaa gtaatcaagc 2224081 acattgcgga tcccgctgat cgcaccctcg atcgttcccg caaaaaacgc ctccgtctgg 2224141 cggatcattt tatctatacg gtgatgcata ccatcaggcc agtcatccgt atggttatgc 2224201 acatgaagaa gaagcccgtt atacgtttcg gcaaacatgg gtatattttc tgacaaatcc 2224261 gtcagctgca cgattaaaac aggcacccct ttatacaacg cccagccaat cccgccaaaa 2224321 aaaagaacat aaatgaccaa gatgctcaaa gtcctaggca atcctttgcc atgcagccat 2224381 tctgtgaccg gaagcaataa ataagatata aaaatagaaa tgatcaaggg aataaagatc 2224441 gtttttatga cgagccaaaa gggtgaccat aacatatcaa gcataaaaaa gacatagact 2224501 gttaacagaa ccagcaaaca aatagccacc cacaacaaaa gctgcaccgg tttttggagc 2224561 atctgctttc acctcaccta tatcttttga ggtttacaag gaattattct ttatgtttct 2224621 ttagtcagtc agaagtcatg gacatttttt cacttttaat tttcagaaaa gtttgatcat 2224681 ttactttttg gtcaaatttt ctgataggag gattgcgatg atcacatttc aaaatgtaaa 2224741 caagcattac ggagattttc acgtgttaaa acaaattaat cttcaaatcg aaaaaggtga 2224801 agtcgttgtt atcatcggcc catccggttc cggtaaaagc acattgctca gatgcatcaa 2224861 cagacttgag tcgatcaatg agggagtgct tacagtaaac ggcaccgcca ttaacgacag 2224921 aaaaactgat atcaatcaag tgcggcaaaa tatcgggatg gtgtttcagc actttcattt 2224981 atatccgcat aaaacagtgc tgcagaacat catgctggct ccggtaaaag tgcttagaca 2225041 atcacctgaa caagcaaagg aaacggcgcg gtactatctt gaaaaagtcg gcatcccaga 2225101 caaggctgac gcctatcctt cccagctttc cggcgggcag cagcagcgtg ttgccatcgc 2225161 aagaggactg gcgatgaagc cggaggtcat gctgtttgac gagccgacat cagcacttga 2225221 tcctgaaatg atcggtgagg tgctagatgt catgaaaaca ctcgccaaag aaggcatgac 2225281 aatggttgtc gtgacacacg aaatggggtt tgccaaagaa gttgccgacc ggattgtctt 2225341 cattgacgaa ggaaaaattt tagaagaagc agtgccggct gaattttacg cgaacccgaa 2225401 ggaagaacgg gcccgcttat tcttaagccg tattttaaat cattaaaaca gaaatggggg 2225461 agcttgtatg aaaaagattt tttctttagc attgatttct ttattcgctg tcatcttgct 2225521 tgccgcttgc ggcagcaagg gatcaaacgg agaagcctca aaggagagca aaaaagatac 2225581 gctagccgcc attaaagaca atgacaaaat tgtcttcggc gtaaaaacgg acactcgact 2225641 gttcggtctt aaaaatccaa gctcaggtga gattgagggt tttgatattg atattgctaa 2225701 acaaatcgct aaagacattt taggtgatga gaaaaaagct caatttaaag aggtcacctc 2225761 aaaaacaagg attcctatgc tgcaaaacgg ggatatcgac gccattgtcg ccacaatgac 2225821 gatcactgaa gaacgaaaaa aggaagttga cttttctgat gtctatttcg aggccgggca 2225881 atcgcttctc gtgaaaaaag gcagcaaaat caagagtgtc gagaatcttg gcaaaggctc 2225941 aaaagttctt gcagtaaaag gctccacctc ctctcaaaac attcgtgaaa aggcgcctga 2226001 agcatctgtt ttagaatttg aaaactacgc agaagccttt acagccctta aatcggggca 2226061 aggcgatgcc ctcaccacag ataatgcaat tttatatgga atggctgatg aaaataaaaa 2226121 ttatcaatta acaggaaagc cttttacaga tgagccttac gggatcgccg tgaaaaaagg 2226181 gcaatctgct ctcgcgaaag aaatcaacgc ttcacttaaa aagatgaagt cggatggcag 2226241 atacgatgaa atttataaaa aatggatcaa agaagaccca gctgaataac aaccatcccg 2226301 ggatgagcag gcgatgctca tcccaatttg ataaggagtg aataggcaga tgaatgtgtc 2226361 aattcttttc gataacttca gcatgtatat ggacggtttt taccatacct tgctcgcaag 2226421 tgttatcgcg ctggccggca gttttgtcct cggcgttgct gtagcggtta tgagaataac 2226481 agtctttaag ccgctgcaat ggctcgggac cgcatatgta gaattcatcc gcaacatccc 2226541 tcttctttta attacctttg ttttctattt cggacttcca aacgcaggcc tgaggcttga 2226601 cggttttcaa gcgggaacgg ttgctctcac catttatacc tctgcgttta tcgctgaagc 2226661 catcagagca ggcatccagt ctgtttcaaa agggcagatg gaagcggcac gctcgtcagg 2226721 ctttacctac agccaagcca tgctccatat cattttgccg caggcaatca aaatcgtcat 2226781 tccgccttta ggcaatcaat ttttaaactt agtcaaaaac tcttcgattc ttggggttgt 2226841 ggccggattg gatcttatgt accaagccga tttagtttcg tcgagcacac tcgttgtatt 2226901 tgatgtttat atttttgtgg cgctttttta cttagtgctg acgattccgc ttagcatcgg 2226961 tgttaactat ctggaaaaac ggctggaaaa aagctattga taaggagtga gttacattgg 2227021 atttcatcgg tgcttattca caggagcatt tagcgttttt atgggatggc tttctcgtca 2227081 ccttgtacgt tgctttcatc tccatcattc tgagcttttt cttcggttta atcgcaggca 2227141 ccctgcgtta tgcgaaagtt cccgttcttt ctcaattgat tgcagttctc gttgaaacga 2227201 tcagaaacct ccccttgctg ttaattattt tctttacgtt ttttgccctt ccggaaattg 2227261 ggattaagct tgaaattaca gctgctgcaa ttacagcact aacgattttt gaatccgcta 2227321 tgctatctga aattatccga agcggactga aatcaattga caaaggacaa attgaagcgg 2227381 cgcgctcctc cgggctgagc tatacacaga ccctgttctt tatcgttatg ccgcaagcgc 2227441 ttcgccgcat ggttccgccc atcgtaagcc agtttatttc tttattaaaa gatacatcgc 2227501 tcgctgttgt gatcgccctg cctgaactga ttcacaacgc gcaaattatt aacggccaaa 2227561 gcgctgacgg cagttatttt ttcccgatct ttttacttgc ggcccttatg tatttcgcag 2227621 tcaactacag cctttcactc gcagcaagac gcctcgaggt ccggcaaaca tagaaaagga 2227681 tactctttgg agagtatcct ttttgcatta aaacattttc gtaattcttc ttctcatccg 2227741 cttcatgctt cgattattca gcatgtcaga ttgagtcgcc attcggtaca cgagagctcc 2227801 ggctcccatt gccaaaagag aagtcatcgt ccgattcatc ctgcgcatct cctttcatga 2227861 ttaaaaattg atgctgcgtt catcctcaga aaacaaatca tccaagctgc ttaacgttcc 2227921 gtcttcttcc acctgatgag ttgcaatctt ccctttcgcc actgtcagtt caataaaaca 2227981 gccccagcaa taatattggt tcacgccgat tttgccgata tccttacttt tgcaattcgg 2228041 gcatataagc atacctcaca cctctatccg ttcagaacga tctcgtcttt ccgcacctcg 2228101 acaagcgaat ccgctctttg gatctggcgc ttgcttcccg ccaggtcaga aaagaaaccg 2228161 tccgagagtt catatgctac gattatgccc ctgtccaaac aaaagtatac atcttccagc 2228221 atccccaata tatccccctc ttgcgatttc acaagcttca tcttcatctg ctcgtatgtg 2228281 aagcatgatt tcggaagagg caaaagctgt tctgaactga ccgaagccaa tatgcggtca 2228341 tcaaaaatgg aagagatatc acacgcccgt aatagcgcat gatgatgatg caaaaagcgt 2228401 ttttgtgcaa gaataaaccc aagacaatct cctttcagag aaaaacaaat atcggaaatt 2228461 gtcccgagat aactagaagt tcgttctgag tatactggga atccttctac ttcatggcat 2228521 gttctcaaag tgtgatcaac caccttttgt tgaacaggct taggttttgc tttgcgcctt 2228581 agactcatac gatgaaatca attccactgc aaatgaaaaa aaactcccgc ttgcacggga 2228641 gcattttatt gctgttcttc tttcataaaa tcgaatggtg taatgccttc catgccaatg 2228701 ttggcgtcgt gtacgctgaa cgggagctct ttttgcaaag cttcaagctc ggcatccatt 2228761 tcctcaacct gtacggacag cctgtttttc aaggaggtct gtctgacagt tgcatcatta 2228821 tttttcacgc cccactccag cgcctcctct tccccgcata aaatgagaaa tttcttcgct 2228881 cttgtaatcg cggtataaag aaggtttctt ctgagcattc tataatagcc tttcacaaca 2228941 ggcaaaacca caatcggaaa ttcacttccc tgcgatttat gaatagaaca gcaatacgca 2229001 tgggtaaatt gattaaaatc ttttttcgta aatgtcattt cattgccgtc aaaagaaacg 2229061 acggccatgt cttctttttc tgtattttcc tttgcataaa atatcgacgt gatttcgcca 2229121 atatctccgt tgaacacatt gttttccggc tgattgacaa gctgcaaaat tttatctccg 2229181 gttctgtaga caacatcccc gaacttcaat tctctccgtt tttctttagg aggatttaaa 2229241 atgtcctgca gcatcacatt caattcatta atgccggctt ttcctctgta catcggagcg 2229301 aggacctgaa tgtcctttgc tgtatagcct tttttcaatg cattggcgac aaccttctca 2229361 actacttctt tgatttgcga cccgccgcag cgaataaagg aacggtcctt tgtcggggca 2229421 gtcaaattgt tcggcagcaa tccatttttc atctggtggg caagctcgac gattgatgac 2229481 ccttctgcct ggcgatagat gtctgtcagt ctcacagtcg gaatcacctg ggatgccagc 2229541 aggtctctga gcacttgtcc cggaccgacg gaaggcagct ggtcttcgtc tccgacaatg 2229601 atgatttgta tatgatcagg gatcgccttg aacaaatgat tcgccagcca tatatcaagc 2229661 atactggctt catcgataat taacagcttc ccttcgatcg gctgatcctc tgtatgagta 2229721 aagccttcag cgccgttcca gccaagcagc ctgtgtatcg taactgcagg gagtcccgtt 2229781 gattcactca tccgttttgc tgctctccct gtcggagcgg ccaaaacaat cggaaaagct 2229841 tcatcctttt tataagctga cgggtctagt gacacaccgt gaagctctcc gtagagctcg 2229901 acaatccctc tgattaccgt cgtttttcct gttcccgggc cgcctgttaa aagaagcatc 2229961 ggcgaggaaa gggctttttg aatcgcttcc ttctggctgg gggcatactg aacgtccatc 2230021 cgttcttcca gttctcccaa cgcgagcaaa aactctgatt cgggaaactg gttctcatat 2230081 tcggtttggc tagcgatatg tttcacacgc tttgcaacgt tttgttctgc gtaaaacagc 2230141 gaaggaaaat aacagcggcc atcttctatg acaatgtctt tattttctcc aagggcaata 2230201 attgcgttag cggcatccat ttctgtaatg cgctgccctt cccttgctga ctggtttaac 2230261 agtgattgag tgtcgatgat cagctgttcc gtttctatgt acgtgtgccc ctctgacaga 2230321 caagtcgttt caagcgtgta caaaatagca gcttttaccc gctcaggatg attacccgaa 2230381 agacccattc tgctgcccag ctcatccgct tttccaaacc cgatgccttc tacatccttc 2230441 acaagctgat aaggattttc ctgaatcttt tcaagcgtct cggattcata ggcttgatag 2230501 attttcatag acagctgcgg gccaaagcca aactgattca aggaaatcat gatttgctcc 2230561 agtccctgat gccgctgcaa tgcgccagcc agcgtgtctg ctttcttttt tgagagtctg 2230621 ggaacatcat aaagcactga agcatcagcc aatattttat taatggcgct gtcgcccagc 2230681 tttttcacaa tttcttcagc tgtttttttg ccgatcccct cgaataaatc actcgataaa 2230741 tattgaatga tgccttcctt agtcgttgga atctcctttt tgaaatgctc cgcctgaaat 2230801 tggagcccga attttggatg ggttacgatc tttccgtaaa acgtgtaggt ctcttcttct 2230861 tgaagcgcag ggaagtagcc cgtcacggat acggctttat cttcaatggc ttcggaggtc 2230921 tctgtgactt tcactttcag aaccgtatat aaattggtgt cattatgata gatgactgtg 2230981 ttgactgtcc cttttaaata gggctcttcc tccagtttaa gctgatccgg atgctgctgc 2231041 acgagctgtc cctcctcctg tgcctgttat gatggatcaa tcagtttttt agcatgaagc 2231101 gcaagcatat gatctggctg gatatcgatt gccttgtcca gcatttccag cgctttttct 2231161 cggttttctt tataagcata agtgacaccg gcattataaa atgcatctgc atgccccggg 2231221 tcttgctctg tcacagctgc gaattggctg agcgcttcgt ccagcatgcc ctcgttggct 2231281 aagcacatcc cgaattgaaa acgcgcttcc gtatcgtttt cattcagttc gactgctctt 2231341 tgtaaatatg gcagtgcaag cttaggctgt tcgagcttga caagtaccgt tccgagcatg 2231401 taaaacaggt cgccgttttc catccccgca cgtagcgctt tttcaaacat gtctttcgct 2231461 tctttgtaca tttcttttac aacatagaca tttcctgctc cataataagc agtggctgcg 2231521 ctactgtcta attcaagcgc tttatcataa aacgcaagcg cacgttccag ctcgtttacg 2231581 gatgaaagaa ggttggcaaa attgatatac ggaatcgcgt cttctttatt ttcttcaatc 2231641 gcttttgtaa atgcctctgc cgctttctcg taatcgcctt cctgcatcgc ctctataccg 2231701 agttgattat aatccaccga tcatcttcct ttcattaaaa aaccccaact cagtgttgag 2231761 gtttttcatc ttttatacgt accacaattt tgttccgtct ttgtacacat catcaattgt 2231821 cccgccgcca aggcattctt cgccgtcata gaagacaacg gcttgtcccg gcgttacagc 2231881 gcggacttgt tcatcaaaga tgacttccgc ttcaccttcg ccagtcatgc gcactgttac 2231941 tttatgatcc tcttggcggt aacggaattt agccgtgcag gaaatctctt cgcccttcat 2232001 gatatccgaa cgtacccagc tgatatttgt tgctgtgatt ttgtcggaat ataaaagcgg 2232061 gttatggaac ccttgatcta cgtagaggat gttcttttca agatctttgc ctaccgcaaa 2232121 ccacggctcg ccgcttccgc cgatgccaag gccgtgacgc tgtccgatcg tatagtacat 2232181 caacccgtcg tggcggcctt ttacttcgcc gtccatcgtc atcatatcgc ccggctgtgc 2232241 agggagatat tggctgagaa acgttttgaa gttgcgttcg ccgataaagc agatgcctgt 2232301 actgtctttt ttcgtcgctg ttgcaagttc tgcttctttg gcaatttcac gcacacggct 2232361 tttttgaagt tcgccgatcg ggaacatgac tttgctcagc gtatcttctg tcagctgatt 2232421 caggaagtac gtttgatcct tgttttcatc aatgccgcgc agcattctga cttttccgcc 2232481 gcttctgtct actcttgcat agtggccagt cgctaaatag tcggcgccaa gtgacaatgc 2232541 atgctccaaa aaggccttga atttaatttc tttgttgcac aatacatccg ggtttggtgt 2232601 tctgcctgct ttatattcat caaggaagta ttgaaatacc ttctcataat attgcttttc 2232661 aaagtttacg gcataatacg gaattccgat ttggttgcag acgcggatca catcttcata 2232721 atcctctgtc gccgtgcaaa aaccgttttc gtccgtatca tcccagtttt tcataaagat 2232781 tccgattaca tcatagccct gttcttttaa cagcagggcc gccacagatg agtctactcc 2232841 gccggacatg ccgacgacga ctcttgtatc ctccggccgt ttttccattt cattcactcc 2232901 aattactacg ccgccttatt atgtcagccg tttgacaacg tcggccacat gtttggcagc 2232961 agttttcact tgctcagccg tattgccgag gccgaagctg attcgaatag aggacgtcag 2233021 ccggtcactc tcttcgccga acatagcagt cagaacatgt gacggcagga ctgaaccggc 2233081 cgtgcacgct gaaccgctgg agacagcgac accagccata tcaagattaa ccagcagcgc 2233141 ttccactgac acaccgggga aataaagatt cagaacatgc ggcagactat gctctttgtc 2233201 cccgttgacc tcgaatgcca cacctgcatc tctaagcgtg tcggcaaaga ttgctttaaa 2233261 cgattgatac ttctcgtttt tttcgtcacg ttcttcactt gacagcttga tcgcttcttt 2233321 cagcccgaca atgcctggaa cattttccgt tccggcacgg cgttttcttt cttgctctcc 2233381 tccgaataaa aggggtgaaa gcttcacatc tttactagca tataaaaagc ctgtcccttt 2233441 tggcccgttg agcttgtgcc cggaaacaga cagaaggtca atatggctgt ttttcacatc 2233501 aattggcagc aacccgaatg cctgaacagc atcggtatga aaataagctt tgtgttcctt 2233561 taacagctca ccgatttctt cgatcggctg cactgttccg acttcattat ttccatacat 2233621 cactgtcaca aggattgtat catcacgcag tgcttctttc acctgttttg cactgactct 2233681 tccattttgg tcaacgtcca gatacgttat gtcaaatccg tctccctcaa gtttttcaca 2233741 tgtgtgaagc acggcgtgat gctcaatttt tgttgtgatg atatgtctgc caagatcttt 2233801 tcttgcaagt gcggttccca tgatcgccaa gttatcagct tccgttcccc cgcttgtaaa 2233861 aatgatctcc tgctctgccg ctccgatttc tgctgcgatc tgcgctcttg cttcatccac 2233921 ccattttcga gattctctgc caaatgaatg aatactggag ggattaccga aactgccgga 2233981 gaagtgcggt atcatttgtt ccagcacgcg ctcatccatc ggagacgttg cggcatgatc 2234041 taaataaatc cgttccatta tgtttacacc tctgatctaa atatagaaca tataagcttc 2234101 ttgctctccg tctgtatagc tggcaagatc ctctaatgtt gtactgtcta aaacctcttt 2234161 tacagcatcc cggatgcgaa tccagagctc acgcttggca ggctcctcat cttccagcac 2234221 ttcaacaggg ctgatcggcc cctcaagcac acggataata tctcccgcag taatggcatc 2234281 cggctcactg cctaatacat atccgccata tgcgcctctg atgcttttca ctaaaccggc 2234341 atttctgagc ggcgatacca gctgctccaa ataatgctcg gacaaattat tcgtctgtgc 2234401 gatgcttttt aatgaagtcg ggccttcacc gtgctttttt gcaagctcga tcataatggt 2234461 gagcccgtat cttcccttag ttgatatttt caacatgaac acctctgtta tttcatgatt 2234521 ttccacattt ataatggtaa tttctatatg tttcgtccgt ttattatctt atagaccaac 2234581 tgttattata acataccttc agcgaatttt cattgaggca gaaggaaagg ggcctttacc 2234641 cttttctaat gtacggtttt ccgttaccct gtaattaagt aaggagagat gatagatgaa 2234701 gccattggca tatcggatgc gtccgacaaa aatagaggat attatcggcc agcagcatct 2234761 ggtggctgaa gataaaatta ttggcagaat ggtccaggca aaacatttgt catccatgat 2234821 tttgtacggg ccgcccggaa ttggaaaaac atcaatcgca acagcaatcg ccggttcaac 2234881 aagtattgct tttcgaaagc tgaatgctgt cattaacaat aaaaaagata tggaaatcgt 2234941 agctcaggaa gccaagatgt ccggccaagt gattttgatt ctggatgaag tccacaggct 2235001 ggataaagga aaacaggatt ttctattacc ctatttagaa aacggaatga tcattttgat 2235061 cggagcaacg acggctaacc cgtatcatgc cattaatccg gcgatcagaa gccggaccca 2235121 gatttttgag cttgaaccgt taacacctga actgattaaa caggcactgg aacgtgcgct 2235181 ccatgatgag catcggggcc ttggcaccta ttctgtatcc attgatgatc aggcgatgga 2235241 gcattttgcc cacggatgcg gaggagatgt ccgctccgct ttaaatgcgc ttgagcttgc 2235301 cgtgttgtca acgaaggagt cagcagacgg tgaaattcac attacattag aaaccgcgga 2235361 agaatgcttg cagaaaaaaa gcttttctca cgataaagat ggtgacgcgc attatgatgt 2235421 actgtccgct tttcaaaaat caatccgcgg ctctgatgcc aacgctgctc ttcactattt 2235481 ggctagatta attgaagccg gtgatctgga gagcatcgca agacgattgc ttgttatcgc 2235541 ctatgaggat atcggtttag caagcccgca agccggccct agagtgctga acgctattca 2235601 gaccgctgag cgagtcgggt ttcctgaagc gcgaatcccg ctggccaacg cagttattga 2235661 gctttgcctc tcaccgaaat caaactctgc cattctggca atcgatgagg ccctggcaga 2235721 tatcagagcc ggaaaaattg gggatgtccc gaagcattta aaagacgcgc attataaagg 2235781 agctcaggaa ttaggaagag gaatcgacta taaatacccg cacaattacg acaacggttg 2235841 ggtcgaacaa caatacctcc ctgatcctct gaaaaataag caatactata agccgaaaca 2235901 gactggaaag ttcgaatctg ccttaaagca ggtgtacgat aaattaatga aaagaaaata 2235961 aaacaaaaaa acagccttga tcatcaaggc tgtttttatg cattatttat ccttcacacg 2236021 tttgatttca atgtctttca aaagatccat gacaacatgt ccgcccataa tcaaacctgc 2236081 aactgacggc acaaaagcat tagaggaagg cggcattttt gctttacgta ttttcgcttc 2236141 gtcattcccc acttcttttc tgacatcttc ccgaataaca atcgggcttt catcagagaa 2236201 aatcacttga acgccttttt tgataccctc cttgcgtaat ttcgtacgaa cgaccttcgc 2236261 aattggatca gtgtgcgttt ttgagatatc agcgatttgg aagcgtgtcg gatccgtttt 2236321 atttgcagca cccatgctgg agatgagcgg aatatcccgt tttagacatt ctttcattaa 2236381 atgaatttta taacaaatgg tgtctgacgc atcaatgaca tagtcaagac catagtcaaa 2236441 aaactgctca tacgtttcct ccgtatagaa catttttaac gcgatcactt cacactccgg 2236501 gttaatgtct gcgatccgcg ccttcattaa atcaactttc ggctgtccga cagttgaaag 2236561 cagcgcgtga agctgacgat ttacatttgt aatgtcgaca tcatctttgt cgacaagcag 2236621 aatgcggccg acgcctgacc gcgcgagagc ttccgccgcg aacgacccga ctcccccgac 2236681 tccaagcaca gcaactgtgc tgtttttcag cgtttcaagg ccttcttttc cgatagctaa 2236741 ttcattgcgt gaaaactggt gtaacaagaa cctcactcca cattcgtatt ctggtttcat 2236801 ctataaaatg gctgatccat gagcagccgt tttttctgcg cacaaaaaat aaagtcccaa 2236861 tagtgccgtt gcagctttcc tttgttttga acccgctctc agcaggtggg tgccctcttt 2236921 taaatcttgt aagtcctctt taccgaatga aaagaggcat gtacgccatt taaaaatgcg 2236981 ggctcccaaa tcaaaaaaat gttcggtcaa aactaggtgt acaactaaca catcaggact 2237041 ttatttaact tgtcaaaatc atatcacaga cgattttgat tttcaagaat cgaactgcaa 2237101 attcagttct taactttttt cttgatagaa agatgaagct cgtcaagctg ggcgtcgctt 2237161 acttcgcctg gcgcttctgt catcaggcag cttgcacttg ccgttttcgg gaatgcaatc 2237221 gtatctctca ggttcgtacg tccagcgaga agcataacga gacggtctaa gccgagtgcg 2237281 attccgccgt gcggaggagc gccgtattca aatgcttcca gcaggaatcc gaactgttca 2237341 gccgcttctt ctggtgagaa gccgagaagc gcaaacattt tttcctgaat atccttttcg 2237401 aaaatacgga ttgaaccgcc gccaagctca tagccgttta agacgaggtc ataagcttgc 2237461 gctttcatgt cttcaggcgc tgtttcaatc agctcaaggt cttctcggac aggcattgtg 2237521 aacggatggt gcgctgcgta aaaacggcct tcttccggat catgctctaa tagcggccag 2237581 tcgatgaccc ataagaaatt gaacaatttt tcgtcaatca gtccgcgttc tttcccaagc 2237641 tttaagcgca gggcgccgag tgatgcggcc acaacttcga attgatccgc tccgaacagc 2237701 agcaaatcac cttcagcagc atcaagtgct tcaatcagct tagactgctt ttcttcatca 2237761 aagaatttag cgatcgggcc tttcactccg tctgcctcaa ccttcaccca ggcaagccct 2237821 tttgccccgt agtttgcagc aaaagcgcca agagcgtcga tgtcttttct ggagtaatcg 2237881 ccggcaccgc cttttacatt gatggctttg accacgccgc cgtttgctac agctgatgag 2237941 aacactttaa attccgtatc ctttacaatg tcagacacat ccgtcaaaag catgtcaaaa 2238001 cgcgtatccg gtttatcaga cccgtacttg ttcattgctt cgtcatacgt cattcgagga 2238061 agaggaagct gaagttcctc accttttgtt tcacgcataa cctttgccat catctcctca 2238121 gccaatgaca taatgtcttc ctggctcata aaggacattt caatatcaat ttgcgtaaac 2238181 tcaggctgac ggtccgcacg caagtcttca tcgcggaaac agcgggcaat ttgataatat 2238241 cgttcaatgc ctgataccat cagaagctgt ttaaatagct gcggagactg cggcagcgcg 2238301 tagaactcac cttcgtgcac acggctcggc accaagtagt cacgtgcgcc ttcaggcgtg 2238361 cttcctgtta aaatcggcgt ttcaatatca agaaacccat tttcatctaa aaagctgcga 2238421 acagctttcg tcacgttatg gcgcagctgc atcgtctgga acatagccgg tctgcgcaaa 2238481 tctaagtaac ggtgttttaa acgaacgtcc tctgacactt cttcagcttg atcagaaatc 2238541 gcaaatggag gtgtctttgc agcatttaat acgttcactc catcagcatg tatttcgatc 2238601 gcgcctgttt tcaaattcgg attaactgtt ccctcttcac gcgccaccac ttttccttga 2238661 atatcaagca cgtattcatt tctgatgcct tccgcaatag caagcgcttc ttttgacaca 2238721 tcagggttaa aaacgacttg aacaatgccc gtacggtcac gcaagtcaat aaaaatcaat 2238781 ccgccgaggt ctcgtctttt ttggacccag cctttcagcg ttacagattc gccaattgct 2238841 ttttcagtta tatcaccgca ataatatgtt cttccaaaca atgcgtttca ctccttatcc 2238901 cttttggttt gccttcatca catgtataaa ttcatcaagt gccacttcaa tctgttcgcc 2238961 cgtctgtgca tcctttacat tgattttgtt ttgggcaagc tcatcttcac ccaaaatcgc 2239021 aataaatctg gcctttaagc gatcagctgt tttaaactgg cctttcattt tcttattttc 2239081 ataatcgatt tcactggaaa tgcctgcttc tctcagtttg tacaccaatg aaacagaata 2239141 atcctttgct ttttcgccga gtgtgacgat atagcagtcg attcccttat caacaggcag 2239201 ctctcttttt tcagcatcaa ttgcggcaag caagcgttcg atgctcatcg caaatccgat 2239261 gcccggtgct tcaggtccgc cgatctgttc gacaagcccg tcgtagcgtc cgccgccggc 2239321 aagtgtcgta atcgcgccaa agccctccgc attgctcata atttcaaatg cggtgtggtt 2239381 gtaataatcc agccctctca caaggttcgg atcgatttca tacgaaatgc caagatcatt 2239441 taagtattgt ttcacttttt caaaataagc ggctgattct tcatttaaat atgtcaaaat 2239501 cgaaggtgcc gatttcatca gctcatgatc acggtctttt ttgcagtcca aaattctaag 2239561 cgggttcgtg tgcagccggg actggcagtc tgaacaaaat tcttcgatgc gaggctcgaa 2239621 gtgtttcacg agcgcttctc tgtagctttt gcggctatct tgatcgccga gactgtttat 2239681 gacaagctta acgttttcta aacctgcttt ttcataaata ctcatcgcaa gcgccattac 2239741 ttcagcgtcg attgcagggt ctttcgaacc aatcgcttca attccaaact gataaaactg 2239801 gcggtaacgg cccgtctgag gacgttcata acggaacatc ggcccgacat aataaagctt 2239861 tgtcggctgt acaggatttg cgaacagctt gttttcatta aaagcgcgaa ccgcagcagc 2239921 tgttccctcc ggacgaagcg tcaggcttct gcctttgcgg tcctcgaagg tatacatttc 2239981 tttttgtacg atatccgttg attctccgac gcctctggca aacagttctg tatgctcaaa 2240041 aatcggtgtg cggatttctt tatattgata agtgcggcaa gtgtctctca taatttgttc 2240101 aacaaactgc cagcgatctg attctccagg cagaatatcc tgtgttcctc tcggaatgtt 2240161 atatcccata ggtagacctc cttatgtatt ccttataaaa tatccaatga tcgttaatga 2240221 tgaaaatgaa aaaaactccc gcccctacta tacatgatag tagggacgag agttataccc 2240281 gtggtgccac cctagttgga atacgttcat attcccgctc gatcctttaa cgcaggttca 2240341 cgttcactgc ctaatggcgt tattcacgcg ttcagcagga aacctccgga gtgttgtttc 2240401 gagaaagacg caatgggatc cgctttcagc ctggggcggg ttcctctcta atcatgcaat 2240461 ctgacctact cttctccatt attggttcaa atctttcatc atttgctatg tactcaattt 2240521 ctattataat aatgggattg gggttctctg tcaagcttta ttccggttgt ttttcctcag 2240581 cgctgcttct ttggacataa gaccaaattc agatgctgtt tccgtaagat aaccagtcgt 2240641 atcgggatct gcgtgatcgc tgtaatgcag attcgcttca ccgtcgtgaa atgcacgtcc 2240701 catttttgga tgatatttca tgatttgcac acctttttga ttgtatttac gcttagtata 2240761 aacaaatcat tttattttta tttaaaaatc agaaaggact ttacgatatt aaacaagaat 2240821 gcttttttaa tgatcatcag aaaggaggac acaatgaaca agaaatactt tgtccttatt 2240881 gtatgtatta ttttcacctc agcgctattc ccgacctttt catccgttac agctgctcaa 2240941 ggagaagcgg tcatcgcaac agatgaaatg aacgtcagaa gcggcccagg gcttagctac 2241001 ggcattacag cggaagtaaa aaagggagaa cgctatccaa ttttaaagga agatggagac 2241061 tgggtgcaga tacagcttgg ttctggagaa aagggctggg tagtctcctg gcttattaca 2241121 aaggaagacc aggccagcac aagctcctca ggaagcagtg acactgtgac atcaacagac 2241181 cccgatctgc ggatgagaag cggcccgggc acttcctacg aagtcatcgg caaattcccg 2241241 caaggcagcc aagcatctgt cattgataaa gattcgggct ggatcaagat atcctatcac 2241301 agtgccaccg gatgggtatc atctgaatat gtcacatcag gaggcagcag ttcagcgtct 2241361 gatgagagtg accaaaccga ggattccggt gcgtcaacga cgggcacagt cggtgtttct 2241421 tcgctaaatg taagagcctc cgcctcacat gacgcggcaa ttataacaaa acttgatcgc 2241481 ggaacgaaac tgacggttct caacgagaaa aatggctggg ctcacattga ggtgaacggg 2241541 ctaaaaggct gggttgcaag ccattacctt ttgactagtt ctgttccagc tgatgattca 2241601 gcaaatgccg gcagttcatc ctccgctaaa aaagcctata tcatgtacgg aggaacgaat 2241661 ctaagaagtg atgcgtcaac atcagcttcg atcgttgagc gcgctgccaa aggagattca 2241721 tacaccatta ccggttcaaa gggaagctgg tatgaaataa agcttgataa cgggcagact 2241781 gcttatgtag ccaattgggt ggtccaaacg tctaaaagcg cagaagaagc aggtgaaccg 2241841 ccagtctctg attccccgtc tggaaacggc tctctaaaca ataaaacgat tattgttgac 2241901 ccgggacatg gaggaaaaga cagcggaacg atcgggtatt cggggaaatt cgagaaaaac 2241961 ctgacgatca aaacggcaaa actgctcgcc agcaaactta gatcggctgg agcggatgta 2242021 tatgtgacac gccaggatga tacctttgtc agcctgcagt cacgggtctc tacctctcac 2242081 taccgtaacg ctgacgcctt tatcagcatt cattatgaca gctatgcgga tacctctaca 2242141 agaggcagta cagcatatta ctacagtcct gccaaagatc aggaactcgc atcagatgtc 2242201 cactcagaag tggtgaagcg ttcttccatt ccagaccgcg gcgtattatt cggagattat 2242261 tatgtgctcc gggaaaacag acagcccgct atgctgtacg agctgggata tgtaagccat 2242321 ccgcaggaag aagccattgt acatagcaat tcataccaag aaaaagtaac agatgggatc 2242381 gaaagcggat tagagaaata cttccaataa aaaaagctgc cttttggcag ctttttttat 2242441 tttgaatcca taatgagcgt gaccggtccg gagtttgtaa gctgaacatc catcattgct 2242501 ccaaacgttc cggtctccac tttgattcct ttttcacgaa gcaggtcatt ccatttttca 2242561 taaagaccta aagctttatc aggtttggcc gcgttcatgt agttcggccg gcgccctttt 2242621 ttcgtatctc cataaagcgt aaactgtgag acggataaaa tctctcctcc tatatctaca 2242681 agagacagat tcattttccc ttcactgtca tcgaaaatac ggagattgac aactttatcg 2242741 gctaaataag ctgcatcatc ttctgtatca tcgtgagtga tgccgaccag caccataagg 2242801 ccttgtccaa tttggccgac gacctcttcg tccactgtaa cgcttgcttc tgttactcgc 2242861 tgaacaacta atctcttttc taaccccttt agttcatgac gcggcgcaca gaatagatat 2242921 ctctaatctg tttaatacgc tcgacgactt tatgcaagtg attgatattc tggataaaaa 2242981 tcgccatatg gatggttgcc actttattgc gatccgattt gccagagaca gatgaaatat 2243041 tggttttcgt ttcattcact gcctggagta cctcgttcag caatccgcgg cggtcatacc 2243101 caagaatctc tatctcaaca ttgtattcct tgcgcttttg aacttgtgac tcatgttccc 2243161 actctaccgg gatcagccgc tcttgggctt cattcgtttt gacattcgga cagtcttcgc 2243221 gatggaccga aacccctctg ccttttgtga taaagccgac aatatcatca cctggcacag 2243281 gattgcagca ttttgataaa cggacaagga ggttgtcaat gcccttgaca cgaacgccag 2243341 cttcccgttt tcttccttgc gggtatggct taggttcccc agtgacttcc tgaacgatct 2243401 tttcctgttc ttcctggtcg cgctgctttc tctctttttc tgttaggcgg ttcgccacct 2243461 gcagagctgt gatgccgttg taaccgaccg ccgcgtacat atcctcttca tttgagaaat 2243521 taaatttgtc agcaaccttt tgaatattct ccggcgttaa aacatccttc aattcaaaat 2243581 ccaagttttt aatttctttt tcgaccagct cacggccttt ttcgacattt tcttcacgcc 2243641 gctgtttctt aaagaattga cggattttat gcttcgcttg ggatgtttgg gcaagcttca 2243701 cccaatcctg gctcggaccg taggaatgct tagaggtgag aatttcaacg atatcacctg 2243761 tccgaagctt atggtcaagc gtaaccattt ttccgtttac tttggcaccg attgttttat 2243821 tgccgatttc agagtgaatc cggtaagaaa agtcaatcgg aacagaaccg gacggaagct 2243881 cgattacatc tccttttggc gtaaagacat acaccatgtc agagaacaaa tcaattttga 2243941 gcgattccat aaattcttct gcatctgtcg attcattttg aaattctaaa atttcacgga 2244001 accaagaaag ctttttctca aaggttgcac cttcattggc tgctttccct tctttataag 2244061 cccagtgagc cgcaaccccg tattccgcta tttcatgcat ttcaaaggtg cggatctgca 2244121 cttcaagcgg atcgccttta ggcccaataa ccgttgtatg aagcgattga tacatattcg 2244181 gcttcggcat tgcgatataa tctttgaatc tgcctggcat cggtttccag catgtgtgaa 2244241 tgatgccaag caccgcgtag cagtccttta tgctattcac aagaatacgg acagccaaca 2244301 aatcgtaaat ttcattgaat tgcttatttt gcagcaccat ttttcgataa atgctgtaaa 2244361 tatgtttcgg gcgtcccgag aagtcagcct tgatatttac ttcttcgaca cgtttcttca 2244421 cttcattgac aacctcatcg acataaagct ctcgttctgc acgtttcttc ttcatgaggt 2244481 tgacaattct gtaatattgc tgagggttca aataacggag cgccgtatct tccaattccc 2244541 acttaatttt tgaaatcccg agacgatgcg ccaaaggagc aaaaatttcc agcgtttcat 2244601 tggagattct ccgctgtttt tcctgaggca gatgtttcag tgtccgcata ttgtgaagac 2244661 gatccgccag cttgatcaat atgaccctga tatcttgagc catagcgaca aacattttgc 2244721 gatgattttc cgcctgctgt tcctcttgag atttatattt aattttgccg agtttcgtta 2244781 cgccgtctac aagcattgcc acttcttcgg aaaatgcttc tttcaggtca tcgagcgtca 2244841 catctgtatc ttccacgaca tcgtgcaaaa atccgcccgc gattgtggaa gggtccattt 2244901 caagatcaac gagtatcccc gcaacctgaa tcggatgaat aatatatggc tcgcccgatt 2244961 tgcggtattg ctcgcgatga gcatcttcag cgtacagata tgctttttcg acaaatgcga 2245021 tatgctcatc agatagatag ctgcgtgctt tatctataac ttgctcggca gtcaatactt 2245081 gttcgttcgc catggaatca ccttttttaa aatgtaaact gtattgtagt ttattatcaa 2245141 gaaaaaaacg aaagatgtaa agagcagaag ttcaaatagc caaatattat ataaaataaa 2245201 tgcaaaacaa taggaaaaaa gcaccctgac atggagtgct ttttcgttat gcggttatcc 2245261 ttagtatttc atcaatgtta agatgtcgta atcttcgagc ttatttctgc cgtcaaggta 2245321 agaaagctcg attaagaaag cgataccagc aacaacgccg ccaagttctt caacaagttt 2245381 gattgtcgct tcaattgtgc cgcctgtcgc aagcaggtca tctgtaataa gcacacgctg 2245441 accaggctta atcgcatctt tgtggatcgt taatacgtct tttccgtatt ccaagccata 2245501 atccactttg attacttcac gaggcaactt gccttctttg cggaccggcg caaaacctac 2245561 gccaagcgcg taagcaacgg gacagccgat aataaagccg cgcgcttcag ggccaacgac 2245621 caaatcaatt tgcttttctt tcgcatattc aacaatttga tctgtggcat agcggtatac 2245681 atcgccttta tccatcagtg tcgtaatatc tttaaattgc acgccctctt tcgggtaatc 2245741 cggtacaatt gttacgtatt gttttaaatc catctgtttt atgtcctcct cgtactttca 2245801 taagcctctg aatcttgttt catcagctta ttcagccatt ccttcagctc ttcagcagaa 2245861 gaataattca gcttttgatc cagttccatc agctgctgtt tcgcctgata tgtttgtgag 2245921 tctgttaagt cgcgtttctt tgctccgctc acaacagaca gcacaccatt ctctatttta 2245981 acaaaaccga gatcaaaaaa cacctttgtc atgaaattga ttgtttcaac ggaccagcct 2246041 ttatgttttg caagctctga accgtgtttt ttcacgtcaa aagcgcctct tttcagcaag 2246101 aacgcataat accatttaaa gtggtctctt gcgggaaaag ttgataaaaa gtggtcctca 2246161 tgattgagaa aaataaaata tatccgctcg ggcgcctttc cttccagcaa acgtgcgagc 2246221 atgtccagcg aaggcggcgg atccagtaat acaatatatg caccatcgag gtcaaacgcc 2246281 tttgcttgat ctttagaact gatgacgtgc acttctcggc gaaggtcttc agtttgaagt 2246341 aatgttgttg agtcttcttt gaaagagaca atggcccgtt tagcagatgg aagggcggaa 2246401 actgtgtctt cccacgtccg ttttcccctt aaatcaaaca gctgccattc agaaacagcg 2246461 gcatccttta tcataagctg cggctttttt cgattgttcc attcgttgat tgacatctca 2246521 ccgacaatgg aaattcttga acccggtacg atgccttctt gaagctcgcc tttattaaaa 2246581 ccgacgcaat caagctggga cgactcgttt ctgatcgtca ttttgacatg agttttattt 2246641 gcccctatct tgcggacatc ttccagtact gcattttcta cgagaacgtg cggtttcggg 2246701 ttcagcatgc caaaaggaga cagcatgttc atttctgcga tgctttcaac tgtaatgtct 2246761 tcgacgccgc agacaaggtc gacttcctgt acgggaataa aatcctcttc cgtaagcgta 2246821 ttgtccgcta tttcattcag cctgcttcgc aaatccggca catcttcggc tttcagcgtc 2246881 atccccgcag ccattggatg gccgccgaaa tgaggaagaa tatctctgca ttcagaaagg 2246941 ctctcaaata aattaaatcc tctgatgctt cgggccgaac ctttagcgat tcccttttct 2247001 tcatcaatac caagaacaat ggccggtcgg tagaaacggt ccacaagctt tgaagccaca 2247061 atcccgacga ctcccgggtt ccatccggct ttggccacga caattgcagt ttgatcgagc 2247121 ccttgctgtt caaccatttc aatcgcttca tccgtcattt tgctgaccat tttttggcgc 2247181 tctttgttca gctggtcaat ttctgcggca agctcttccg cttcaaacga atcctctgac 2247241 ataagcaaat gaacagcggg atccgcctgt tcgattcttc cgacggcatt cagccttggt 2247301 gcgagctgaa atccgactgt ttcttcgttc gcttctccga tgtctccgcc tgacagctta 2247361 atcagctctt ttaagccgag ccgatttgtc cgtcgaagcc tttcaagtcc tagtgttgct 2247421 attaatctgt tttcgtcatg cagcgggact agatcggcaa tggtgccgat agccgccagg 2247481 tcaagcagtt catcaggaag ttcacccaat aaagcgtggg caagcttaaa cgcgactcca 2247541 accccggcaa gctctttaaa cgggtaagtg cagccaggct gcttcgggtg gacgatcgca 2247601 cggacatccg gaagctccgg tcccggttca tgatgatcgg taatgatgac atccagtccg 2247661 agttcctttg ccaccttcgc ttcatgcaca gcggcaattc ctgtatcaac cgtaatgatc 2247721 aaagagaagc cccgttcttt aatcgaacga aacgcctgtt cattaggtcc atatccttct 2247781 ttaaaacggt caggtatata aaaatcaact tgagccgaca gtttttgcag cgtgtgaagc 2247841 atcactgacg tacttgtaac cccatcggcg tcataatcgc catatatcat aatcttttct 2247901 tgttgtgaaa tcgcctgttt tattcgatct gccgcttctt tcatgccttt catttcaaaa 2247961 ggatcataaa aatcggcatc ctttgtatgt aaaaacagcc tagcgctttc tgccgtatca 2248021 aagcctcttt ttacaagcag ggacgcaaca agaggtgtta tatgcaattg ttctgtgagt 2248081 gatttgacct tatcctgatc tggtcgctgg atttcccatc gcatttttga cgctaacata 2248141 aattcacccc tcaaccaccc tattatacta gagcaggctg aggggtttca aataatattc 2248201 gaaaactagt cttttttctc aatcatggct gatgcatcct gtgtgtcagt ctgatcagca 2248261 agatgagtat cctcttgttt atgtattgct gttctatttt ctttccgcaa ggtttttatt 2248321 tcccgcttca atttcattac ctgaaaaatg ccgacagaaa atacgatcag tgctcccatt 2248381 aaaactgagc ccaaaataac aagaatgagc ggccattctg atcttccaaa caggtaatca 2248441 acttctacgg atcgaacatt aatgactgcg aaaatagcga caattaaggt gaaaataagt 2248501 gcgaaaataa tggtccattg tttattcatt ctcttttccc ccaaacttct tattgaggta 2248561 actttcccaa tcaagactgg ttttaaacat ggcttaacac taggttaagc tccctttgct 2248621 gttaattttt cccggatcag cctcttcagt ccggttccct caccggaaat cacaagtgta 2248681 tcgccttcgt caatgactgt ttcagagctc ggattcagtt gtttatcctg attcttttta 2248741 acaattgcaa tgaccgtcac atgatattcc tgacccacat tcaaatcacc aatcgtctga 2248801 tgaatggcag gcgctcccgc ctctgcttta caccactcta taatcaaatc atcaagggct 2248861 gactcgacct gttctaatgc tttcggttta tatgccattc cgccaagaat tgcagacatt 2248921 tgccttgctt cagcgtcatc aaactgcacg gaggcaacac attcctcatg gtcgttttcg 2248981 tcaaaatagt aaagctctct ccgtccgtca tgatgaatga taattgaaat tttatcacgg 2249041 tttctagtaa tcatttcaac tttttgtcct atgcccggca gctctgattc gcgaaccctc 2249101 atatataaac cctcctacat atctgaaaac cagccataaa cacttttaac accatatata 2249161 tgtttaaatg taagcgtatg tcattatagc aaatgtctat tttaagttca atgaaacttc 2249221 aaaaaacagg ctgccctgca gaggacagcc tgatattttt tattgcgccg aatctttttt 2249281 cagttctctt cctttccatg caagccaaat ttgtgcggca atgtatagag aagaataaac 2249341 gcctgttaac agcccgacca ataaagcaat tgagaagtta gtaatagaag atgctccaaa 2249401 gatcagcaat gtcacaacaa caatcacaac ggttaataca gtgttaattg aacgtgtaaa 2249461 ggtttgctgc aggctcaggt ttacaatatg gttcagatcg gcaaaggttt tcggcttacg 2249521 ctttttcata tgctcgcgga ccctgtcaaa tgtaacgatt gtatcgttaa tggaataccc 2249581 gattatcgtc aagatggccg cgatgaatgt aacatctacc tcaagccttg taatactgaa 2249641 gaacgtgacg ataaagaatg cgtcatatag caatgaggcg atggcagcaa tcgccatttt 2249701 gtattcgaat cggattgaaa cgtaaataat gatgccaata gaagctatag caactgcgta 2249761 cagcgcattt ctcgccagct ccttaccgac tgtcggtgaa actgtgctga catttggatc 2249821 agatccgtat ttgtctttaa aatacgtttt tacttttgca atggtttctt tatctggcac 2249881 cccgacaaaa cgggcaacac cgatattgct cttttcgcct gacagaacta cagtatcagg 2249941 gtccataccc agagattcaa aatccttctc aacttgctct gtcgtcagct tatggtcgct 2250001 ttgcacttca atccgtgcac cgcttgcaaa gtcaatgcca agattcagcc tgaacacaag 2250061 caggataata atcccggcaa ccgtgaccgc actggagaaa ataaagaagt atttgcgttt 2250121 gctcgtgaaa tcccattttt ggaatggcgt atgcggctct gtattttcat ccgtatcctg 2250181 aatatccatg atatgtttct tattgacacc aaaccagcct tttttccgat caagccatct 2250241 gctttccaca aggagagcga ggagaaatct cgataagaaa acggcagtga taaagcttgt 2250301 caaaatcgat aggatcagca ttgtcgcaaa ccctttaaca gagcttgtcc caaagataaa 2250361 gagcacaacc gctgcaataa tggttgtaat attcgcgtca aaaatcgtcg caaatgaccg 2250421 tctgtttcct gaacggaagg cagagcggac tgactttcct agcttgagct cttctttaat 2250481 ccgctcatag gtaataatgt tggcgtcaac agccatcccg acacctaaaa tgagagcggc 2250541 aattcccgga agcgtgagta cggcattcat ccagtcaaag atctggagtg taatgtagat 2250601 ataaacagac agcgtaatca ccgcgattaa tcccggcaga cggtaataga aaagcataaa 2250661 taagaaaata attgcgatac cgacaatacc ggcaaacacc gtatcatgga gagcctgctg 2250721 gccgaattgc gcgcctactg atgtcgaata cttttcagtc agtttcacag gaagtgcgcc 2250781 tgcgtttaaa atgctggcta aatctttcgc ttcttgagct gtgaaatgac cttcaatttt 2250841 tacatcagtt gtatttagtt cctgacttac atttggagcg gatacaaatt taggatgctc 2250901 tttttgaact tctttcttaa aggaatcacc tttatcataa tccaaccaaa tgacaagctg 2250961 gttgtttggc gccattttca tgaccttctt ggtcacttca ccaaatttat cagcgtcttt 2251021 cagcttaatc gtgacaattg gctcatttgt tgtgctatca taagtttgtt tagcgccgtt 2251081 ttcgactaga tcagcaccgt ttaacagttc cttatcattt gcatctctga aagaaagctg 2251141 cgcttcagtc gccaaaattt cacgcgctct gttttggttt gtcacgccag cgagctgaac 2251201 gcgaatccgg ttattccctt caatttggat gttcggttcg ctgacaccga gaacattggc 2251261 ccggcggttc agtgcctcta ctgtgctgac cagaacgtct tttgtgattt tgtcaccttt 2251321 ttttacaggc tgtacatcat acagcacctc aaatccgcct tgcaaatcca atcctaacgt 2251381 aatattgtta gcggcaggct tcgtaaagta gcccaagccc gtgccgatca atagaacgaa 2251441 aaggaaaaac gcaatcaagc gtcctttttt cattatgtat atcctccctt aaacctgtgc 2251501 gaatcaacct gctatctcag cagttcttcc aatgcttcct ggccctcttc actgcccagc 2251561 caattagacg ttttaaatga ctcaacggtt gcatagttca taaattcgcc aattttcact 2251621 gataaaatat cactcgccag ttcataaatg ctcagttccg ttttcttttt ccacttctta 2251681 tctgttaagt atgaccacaa actttcgagt tcaacatcat catacccgag aatcttaaac 2251741 tcttccagtt tgctgtaaag aaacggcctg acgtggtctt tatatagatc ggctggatgc 2251801 ttctccacga attccacgct ccttttttat tgtttttcaa gaagacttgt catgcttgga 2251861 cgacatatac gcatatcttt attgtatatg attccaggta gtttgagaag gcagggggta 2251921 aaaatggcga aacagacgtt tttaaagggc actcttatcc ttatcgcagc aggaatggtt 2251981 acaagaatgc tcgggtttgt caaccgggtg gttatcgccc gttttatcgg tgaagaagga 2252041 gtcgggcttt acatgatggc agcgcctact ttcttcttgg ccactacatt aactcaattc 2252101 ggtctgccgg tcgcgatcag caagctagtc gctgaagcca gtgcgcgcgg agatcatcaa 2252161 aaaacgaaaa atattttagt catgtctctg accattacgg gagtgctcag cctcatcttt 2252221 acaccgctgt ttctgttttt cgcccctgtt atggctgaaa cgatgctgac agataagcga 2252281 acactgtatc cgctcttggc cattacgcct gttgtgccga ttattgctat atcgagtgtg 2252341 ctgaggggat actttcaagg aaaacagaat atgaacccgc ttgctatgtc acaagtcctt 2252401 gaacaggttg tccgcatttc actcgtggct gtctgcacaa cgatttttct cccttacgga 2252461 attgaatatg ctgcagcggg ggcaatgcta tcctcagtgg caggggagct ggcatcactt 2252521 ctttatttat tcgtttgctt taagtataaa aagacaatta aaatcagaaa gcatttttta 2252581 cagtcaatta aaaacggaaa acaaaccttt acccaattaa tgagcgtgtc ccttccaaca 2252641 accgggagcc gctttatcgg aaacctctct tggtttttcg agccaatcgt cgtcgctcaa 2252701 agccttgcca tcgccggtgt ggcaacagtt gccgcaacaa agcaatacgg ggaactaacc 2252761 ggctttgcca tgacgctgct gactctgccc agctttatta catattcttt gtcgaccgcg 2252821 cttgttcctg cgatcagtga aggaatggag cagaaaaaat tgcaggtggt ggaataccgc 2252881 ttagaacagg cgatgcgtct ctgtctgctc agcggaggca tttcagttgt tattttattt 2252941 gtatttgcgg atgagctgat gagagtgatg tacggttcct caggcgcagc tgtatttata 2253001 aaagtgatgg ccccgttttt tctgctttat tatttccaag gcccgcttca agctgtgctg 2253061 caggcgctta atttggcagg agctgcgatg atgaacagct taatcggagc gcttgtcaaa 2253121 acaggcctta tttttgtcct tgccacaagg ccttctcttg gcattatggg cgcggcatta 2253181 gccattgtga caggcatggt gctcgtcacg ctattgcacg cagcaaccgt aagcaaagtg 2253241 ctgccgatca gcatcaaaat caaggagtac gcgctcagct tcgctgttat tgtaatttgc 2253301 ggattcatca gctccgccat caaacaatat ataagctttg gagcatctga ggctgtcaat 2253361 ctagccggat ggattgcggc gagcgccgcc atttatatga tcctcctgct cgttttccgt 2253421 ttaattaaaa aagatgagct tcgccgcatt cccattatcg gacggttgat catccgataa 2253481 tggtcacgtg cggtgcccat ctttttcatc aatatatatt tctccgtctg taaacgagca 2253541 aaatgaaata tctgaagggt ttgtgtatcc gtgtttttgc aaactttcaa gcagccattt 2253601 tctatcttta ctgattctgg acaggttttc tgtttgaatg aagccgtcta taatgagcgg 2253661 catttcgagc tgccgatgct ctccgctgtt ttctttctta acaatagtca gtttgcccga 2253721 cggctctaaa atagcaaatg atacgtcagc tactctgtcg atgctatttt ctctgagctg 2253781 aaccattaaa tcatcaaaat tataacgctg tgatttcatg gcttcttcgt caatttttcc 2253841 atatttgata attatggtcg gcttaccgtc aagaagctgg cggacttttc ggttttttaa 2253901 agaaaagtat gccaaagtca cttgaatgat cattaataca agcattggca aaatggtatg 2253961 aaatagatga tcgtctacgt tttctatggc taaaacggca atttcagcca tcatgataaa 2254021 gacaacgaga tctaaaatac taagctctcc gatctcccgt ttgcccatga aacgaaaaat 2254081 gaccaatatc acaaaataca atacgactgt gcgaaacgca atagtgagaa gctcttccat 2254141 tatgcacctc caactcatta taggttgcaa caaaatgatc aatttatgta agaaaaaccg 2254201 attgcatttc acaaagcttt tacgtctaat tcatgggata agggaataca tttttacaaa 2254261 gacgagccat cagcatgtct gacggttttg aacaaaaaga acagaagcct tttaatacag 2254321 gcagagagga gacaatcatg gaggaaacga aacaagttgg aaaaggcatt ctttacggct 2254381 taatcgccat attttcagcc atgctcctga caagtttagc ggtttcactt ttattgaccg 2254441 caacctcgct ggaagaatca tcatttaact ggctgatcac cgctatctca tttctctctt 2254501 tatttatcgg cgggttcatt tcaggcggga aaggcaagga aagaggctgg atgattggcg 2254561 cattgaccgc cttaagtttt tctctgatta tcttattgtt tcagtattta ggattcggaa 2254621 agacatttac agcagaacag ctgatcttcc atctgggatt tttaggggtg tgcatgctgg 2254681 gcgggatttt cggcgtgaac atgaggggaa acaggtcttc cacataaaaa agagcgggct 2254741 cacttgcccg ctcttttttg tttgctatgt atagctcctg ctgttattca gcagcagaaa 2254801 cttctctgat cgcgcggcgg tcgaacgtaa gacgtgtgtt atcaccagtc ttaattacga 2254861 ctttgctttc gtcgatagag tcaacagtac cgtgcaatcc cccgattgtc actactgaat 2254921 cgcctttttt cagttcctct tgcatttggc gtacagcctt ttgctgcttt tgctgaggac 2254981 gaatcagcaa gaagtaaagg accgcaaaca ttaaaataat aggaaccaat gtacctaaag 2255041 tgccagtcat cattttcacc cctttctgta agcctgttat gtttatttag aagcttttcg 2255101 catttggctt gttatagccg taacgctcaa agaactcttc tctgaaatca cccagacgat 2255161 cctcgcgaat agcctgtctt acctgctcca ttaagtgtaa cagaaaatga aggttatggt 2255221 aagttgttaa tcgaaggccg aatgtttcat tgcagcgaat caagtgccta atgtacgcgc 2255281 gagtgtagtt tttacatgta tagcaatcac actcttcatc aatcggacgg aagtctcttt 2255341 caaatttcgc atttttcata ttgagtcgtc cttcagcagt aaacactgtg ccgtttcttg 2255401 caatccgtgt aggcagcaca cagtcaaaca tatcgacccc gcggatcgct ccgtcgatca 2255461 gtgcgtccgg agaacctact cccatcagat atctcggttt atccttcggc aagagcggtg 2255521 ttgtgaattc gagtacacgg ttcatgacat ccttcggttc acctacagac aatccgccta 2255581 tagcatatcc cggaaaatca agcgaaatca agtccttcgc actttgtgtc cgcagatctt 2255641 catattctcc gccttgtaca ataccaaaca gcccttgttc atcctgacga ttgtgggcat 2255701 tcaggcagcg ttccgcccag cggcttgtcc gttcaactga cctcttcatg tagtcgtact 2255761 ccgccgggta tggcgggcat tcgtcaaacg ccatcataat atcagagccg agtgcgtttt 2255821 ggatctccat cgctttttcc ggagataaaa acagcttgtc tccatttaga tgattgcgga 2255881 aatggacacc ctcttcctct atattacgaa acttgcttaa agaaaagacc tgaaaaccgc 2255941 ctgaatctgt taaaattgcg cggtcccagt tcataaattt atggagcccg cccgcttctt 2256001 tgacaatgtc ttggcccgga cgaagccata gatgataagt gttgctcaaa atgatgcctg 2256061 catccattgc tttcagctct tcaggcgaca ttgttttgac tgtcgccagt gtgccgaccg 2256121 gcataaaaac cggcgtttcg aaggagccgt gaggcgtatg cactttgccc agccgcgctc 2256181 ctgtttgttt gcattctttt ataaattcat agcgtattgg ttgttcagcc acttttgatg 2256241 aggcctcctg ttctcaaatt atataatcag catcgcgtct ccgaagctga agaaacggta 2256301 ttcctcttcc actgcatggt tataggcacg cagaatgttt tctcttccag caagcgcgct 2256361 gaccagcata atcaatgacg atttcggcaa atggaagttt gtaatcattc cgtcaatggc 2256421 tttaaattca tagcccggat aaataaaaat agatgtccag ccgcttgatg ctttaaattg 2256481 cccgtcatgt tctccggcaa tcgtctcaag cgtgcgtgtc gaggtcgtgc cgacagaaat 2256541 gatccgaccg ccattttctc ttactttgtt taaggctgca gccgtttctt ctgacatttg 2256601 ataaaactct gcatgcatat tatgctcttc cacttcatcg gcactcacag ggcgaaacgt 2256661 tccaaggcct acgtgcagtg tgatgaactc aatttgcacg cctttgtctt tcagctgctg 2256721 taagatttct tccgtgaagt gaaggccagc tgtaggcgca gcagcagagc caatttcttt 2256781 tgaatacact gtctggtagc gctctttgtc atcaagctgt tctttgatat atggagggag 2256841 cggcatctct ccaagggatt caagcacctc gtagaaaata ccgtcatatt gaaattccat 2256901 ctttctgccg ccgtgctcaa gctcttccgt gcagattgcc ttcaatcttc cgtctccaaa 2256961 tgtgacaaca gttccttttt tcacccgttt cgccggtttg gcaagtgttt cccatttatc 2257021 accggtttcc tgtttcaaca aaagaagttc cactttcgcg ccggtatcct cttttgtgcc 2257081 gaataaccgc gcaggcagta cccgggtatt gttcaggact agacaatcgc cttcgttaaa 2257141 gaagctgata atgtgtttaa acgagctgtc agtaagctct cctgtatgtt tatcgagcac 2257201 catcagcctt gaagcatcac gctgctccaa cggtacttgt gcaattaaac gttctggtag 2257261 ttcaaaatca aataaatcga ctttcatgat gatttcacct ttattctagt cttttgttat 2257321 ttcattctgc caaaaagatt aagcaaaatt gataatacca cacttataat aatacaagtg 2257381 acaaccggga agaaaaacgt aacatttcct ttttttacaa aaatatctcc cggcatcttg 2257441 ccgacaaaat gcaaaactgc tccgataata agcaaaacag caccaagaat cataatgatc 2257501 ttaggaaatt cagtcatatc ggggagcctc catttggaaa tgatgataaa cggccggtgt 2257561 cacgatcctt ccacgcggcg ttctttgtat aaatccaatt tgcagcagat atggttcata 2257621 tacgtcttca atcgtatgcg attcctcgcc gatggtagct gaaatcgtat caaggcctac 2257681 tgggccgccg ttgaattttt cgatcatgcc catcagcagc ttatgatcaa tatgatccaa 2257741 accgaggcgg tcaacctgaa gccgctccag cgcattctga gaaatgtctt ccgtaatcct 2257801 gctgtcaccc agcacttggg cgaaatcgcg cacccttctc agcaggcggt tcgccacgcg 2257861 gggcgtccct ctcgatcttc ttgcaatttc aagagccgac ggtttatcaa tctcaacctc 2257921 gaatacatca gcggttcttg tgacaatatc cgccagttct tcttgtgtat agtactcaag 2257981 gcgagacatt acgccgaatc tgtctcttaa aggagccgtc aaaagcccca ccctcgtcgt 2258041 ggctcccacc agcgtaaaag gcggaaggtc gaggcgaacc gagcgggcag atgggccttt 2258101 gccaatcaca atgtccaggc aaaagtcttc cattgcagga taaagcacct cttcgatcga 2258161 tctgtgcagc ctatgtattt catcaataaa taatacatct cccggttcca gcgccgttaa 2258221 tatagcagcc aaatcaccag gcctttcaat cgcaggccct gatgtcgtcc gcaattccac 2258281 tcccatttca ttagcaacaa tcgaagcaag cgttgttttt ccgagtccgg gcggcccgta 2258341 cagaagaaca tgatccagcg tctcctgtct cattttcgcc gcatctataa acacgcgcaa 2258401 attttctttt accttatgct gcccgatata ctgtgccaga ttttgcggcc tcaggctttg 2258461 ctctatcact gattcatggt tgtctgcttc acttgagacg agccgttcat ccatgaacat 2258521 caccttactt taatagtttt tgtaatgctt ttttcacata ttggtctgtt gtcagcccaa 2258581 tttcttcttt aaggtgagga agcacctttt tgatttcttt ttcagcatat ccgagaaccc 2258641 tgagggcttc aagtgcttct tcaagagccg tttccgctgt ttgcttttca agcctttctt 2258701 catgattaaa cagattttca atcatttcag gcacaacatc tgccagcttt ccttttaaat 2258761 ctagaataat ctggcgtgcg gttttctttc ctactccagg aaacttgacc aaaaaagctt 2258821 catcttcatt ttcaattgct tggatgaccg ctccgggatc acccgagccc aagatggcaa 2258881 gtgctccttt cgggccaatt ccggtcacgt ttaacagctt tgtaaagagc gccttctcct 2258941 ctcttgttga aaaaccataa agcgaaaaag catcctctct gatatgatgg tatgtaaaaa 2259001 tcgtttcttg gcttctctcc ttatatataa acggattcgg cgtgaaaatc tgatagccga 2259061 tgccgccgtt ctctatgaca atatattggg gagatacata atcaatcgtc cctttaacaa 2259121 attcaatcac gcaaattcac ctctttgact gttcttcatt gtaccataaa aacagccaaa 2259181 gtcttataga aaagttaaca tatgttcgct tctctctcat tctttcacga aaaaaaagac 2259241 atgaatacat gtcttcaatc agcggacgct acccgctgta tgtcttcata tgttcgatga 2259301 catcctcaaa ctccgctttt gtccgaaatg gaatgccttt cagcagattt ttttgcatat 2259361 ggctttccag cctttctaaa tcaatttgaa aaaaagactg aattggttcg gaagctggct 2259421 caggccgccc atgaaaagtg gaaatcactc cattatccga tacaccgata tacccgttga 2259481 ccttgctgag cggagaaata tcgtccattt gcttccggaa gagcacatat cccttttttt 2259541 gttccactag cgtccatccg gcataagctg cccaaaaatc atccatagaa aacacttttt 2259601 catgcttatg ctcaatgctg acatcgccgt ccaaatacac cttttcaagc tgcacatgca 2259661 cctgcagcgg ctcatagtgc tccacttccg cgccaagtgc gcgggaagga gctcctatta 2259721 aaaatactgc cgctgagcaa agaatgccca gcaaaagata cgccgtgctg aatcgtttca 2259781 ccctctacac ctctttgcac acgtttatga ttagtttgac caaagaggct actgcttaac 2259841 cgttttatca aaatttgtct gcacattttc cctgacaaac cgttcctccg tatacacatc 2259901 tgtgctttgc tcagaaattg tcaagaatcg cgtcagaaag gcactgaaaa aatacaatgc 2259961 cgcaaagatc caaatcacgc cacctgcacc gagcggccca atgaaaagac tcacgatgcc 2260021 cggcgcgata aacgcacata aaccagatcc caaattcaac actgacatgg cagcaccttt 2260081 attatcaggt gcaagcgtcg gcaaaagcgc gcttaatggg acgtaccctg ctaaagccgc 2260141 gccgtagcag caggcgataa tcatgagcac ccaatactga tgcccgatca gctgaggcgt 2260201 gtaatacagc gccagcgtaa aaataccgca tccgacaccg ccaaaccaca tgaccgtatt 2260261 gcgccagcct agtttatctc cgactgcacc gaaaatgata ttaaacacaa tattcacaaa 2260321 aaacagcgtc ccccatattt gcagccattc cgaaaccgaa tacccgtatc gtgctaaata 2260381 agtaggaaga aagatggcaa atccaaattg tcctatcgca ttaatcgtct tgaccactcc 2260441 gccgatgcct accttagggt tttcaaacat aatcgtaaat gccttcgaca gttctttcca 2260501 tttcggctga tcttgttttt gtatcggagt aaatttatct ttgttaaaaa ataaggcaag 2260561 aattccgcct gccgccacaa acagtaaagc gctccaaagc gtattgattt ctccaaaggc 2260621 cggaactgca tagctggaat agaacggacc gagcacgtta aggccgcacg taaacataaa 2260681 ccaaaaccag ccgacggctt ttccaagaat attttgagag gtgctgtatg acacccatac 2260741 gagaaaagag tatgcaaaca gcggatatcc caagcctcta agagcatagc tgcccaagag 2260801 agccggataa tacatatgag gaatcgccca gccgataaaa gcggccgaac cgaggataaa 2260861 tgcaagcaat ccgacagtca tcgtttttct cggcccccaa gtttggacaa acgttcctga 2260921 aagccaagct gagatggtga cagcaatgcc gtacatggta aataacgatg cggattgctg 2260981 catactgaga ccatgatcaa cgagaaaagg agacagccag ccttgttcga ggccgtctcc 2261041 aaccataaag atgacaacgc caatataacc ccaaaccatg tgagaaggaa ttccgatttt 2261101 gttcaaaaca tttcctttag catgtactgt attcattttc tccaccgcct acttaaagta 2261161 tcaatggagt atatacccaa gcttgctgaa ttgtaatcct gttagattaa aaagcgattt 2261221 tttcagtgtg ctcaatgcta acaggcatgc caaaagcaag cgattgctgt gctgctctgg 2261281 cgatcctccc ggcctgtaaa ccgtcattgc cggtgcaggg agtctcctgg tttgtgccga 2261341 tcgcttctgc aaaacggaga atctcctcct catatgaatc cttatagcgt tcaaggaaaa 2261401 agaaatgcgg tttatccttc atcacaaaat cagctgttga cacctcaacc gttgtcggcc 2261461 tgctattgtc agccgctgca gagcctttcg tcccgaaaac ctcaacccgc tggtcatatc 2261521 cgtacacagc ttggcggctg ttatcaatca cagccatggc accgttttca aaagtcagtg 2261581 taataacagc tgtatcaata tcacccagct ccgcaaaaga aggattcacc aaagccgccc 2261641 ctttggcata cacttccgtc acttcgcttc ccataatata tctggccata tcaaaatcat 2261701 ggatcgacat atccataaac aatccgcctg acgtacggac ataatctata ttcgggggtt 2261761 ctgggtcccg ggacgtgatt tttaataaat gaggtgtacc gatttcacca ttttcaacaa 2261821 tcgttttgat tttcttaaaa tgaggatcaa agcggcggtt aaatccgact tgaagtgtta 2261881 ccccgtgttt ccggacagcc gcaagcgctt cactcgtttc gtccagagag aaactaacgg 2261941 gcttctcaca aaatatatgc tttttcgcct cggctgcttc tttgatcatc tgtgcatgta 2262001 cggctgtagg agagcaaata aaaatagcat caatatcagg atcatgtaat aaatcacgat 2262061 aatcagaggt tatgtattca atctgatgac tgtcggccca gctttttata cggctcgcct 2262121 gaatgtcaga gattgctttt attttcatgt gaggaatccg gcttatattt tgaacatgaa 2262181 gtttgccgat gcggcctgca ccgataatcc ctgtcacaat ctgttttgtc atggcttctt 2262241 cccccttgat cattcacgaa agcgctttat ttaaaattaa tactatccca tttgtaagcg 2262301 cttttcaaga atggaaatta aacgttctat gtctctttta tcacaattca tgcttataag 2262361 tagccttctt cttcaagacc agatacacta gaattaggct ctttttcctg aacagtttat 2262421 gattttccta taaacagctg cataaaatag agcaaagaag gtgaatgaaa tgctgacaaa 2262481 agcagaggca ctggcccata ccgtcatata ccgcaagaac agcagatttg ataaagtcaa 2262541 agagaaatcc gaggaattaa cactaatcgg caagggaaga agcgcctatg tgtttgcctt 2262601 aacagaaggc ggtcgaaaaa tggcgctgaa agtatttttt ccggaatatc aagcgacagc 2262661 agtcaaagaa gcagcgatct atgaaaaatt agccgggtcc gcattctatc ctgacattta 2262721 cgaaactggc gattcattta ttctcatgga atatattaaa ggtgaaacct tttataactg 2262781 tctgaagaaa ggcattgcaa tcagtgatga catgattcag caggttgaag aagcgctttc 2262841 tgacgcccgg gcagccggac tgaacccgtc agatattcat ttgcggaatc tgatattgac 2262901 agaaaccggg gcggtgcggg tgattgatgt tgcgagattt gagcagacaa aaacatgcac 2262961 gcagtgggac gacttaaaat ccgcatatca tgcactctac aaaaaaccga tattccccaa 2263021 aaagattccg ggtttttggc tggagatcat cgcattttta tataagaaag attggtttca 2263081 aaagcatttc gcacagcgga aaagaaaata ttcttaaatc aaaaaggcag ccgcacaagc 2263141 ggctgccttt atcatgtatt ttttactttc tgacggcaga aatcagtttc atttgttcag 2263201 gcgacagctt aattcgatag cctctcacag ttaagtagac cgcttctggg tccttctcgc 2263261 cggaatgaca atacgttttt tccatttctg tctcccctca ccctttattg gctttatttc 2263321 atcttatcat tgctttattg aggtaatttt aaagaaatgt aaagattata tgaatccgat 2263381 atatagtaaa atgagagaaa aaaagggaga gagtcacatt aagaccgaaa acaccttgag 2263441 cttagatgca gccagaggtg aacttgtaaa tgaaaaaaca cttgtcaaga gaacaatcta 2263501 ctggaattac ccggacagcc gcccagcagt gacgtggatc aatcacaata cagtgaaaat 2263561 cggcaatcag actttacatc ttgatactga tgaaacgtat gattggcgaa aagatgatca 2263621 ttggatccgt gaagaaccgc cgcaggcgtc agtgaggtga tgaaacatga ataagatgaa 2263681 cggaacaaat gatgaaaagc atttcaatca ttttgtgatt gctttatcct ttatatacgg 2263741 tttgactgaa ctaggctatt tgttgctgaa ggattttata acaattgcca taagtttgcc 2263801 tctgtagaaa aacgcagcgt agtcgatacg ccgcgttttt tctttttccc ttcctcttct 2263861 tattgataat tacaggtcat ataatgtgac aaatcgattg tagaaatagt tcgattagac 2263921 caaaatcctt tttatacatg tattcgaatt tgaagtgagg gggaagcttg atggcagatt 2263981 ttgttgctag tttgaatgcg gtcttatgga gtacgcccgt catttatatt ttattgggaa 2264041 ttggattcgc cttttcaatt atgacccgtt ttttacaagt ccgacattta aaagaaatga 2264101 ttgttcagat gttcaaaggc aagagctctg aagccggcgt ttcatctttc caagcgttat 2264161 cgattgcgct gtccggccgt gtgggcacag gaaacatcgc gggagtggcg acagcaattg 2264221 cattcggcgg acccggtgca gtgttctgga tgtgggcgat tgcctttatc ggggcggcga 2264281 gtgcctttgt agaatcaacg cttgctcaaa tttacaaagt gaaacaagac ggtcaatatc 2264341 ggggcggccc tgcttattat atagaaaaag gcttaggcat taagtggttt gccgtcttat 2264401 ttgccgctgc tgcccttatt gcaatggcct ttctaatgcc gggcgtacag tccaactcca 2264461 ttgcggctgg gatccaaaat gcattcggca tctctccttt cgtcacaggg tgcggtctgg 2264521 ttttattatt agggttcatt atttttggcg gcgtcaaacg aattgccaat gcggcgcaaa 2264581 tgattgttcc atttatggcc attggatata tcctgctgtc tttgattatt attgtcatga 2264641 atgtgtctga attgcctgct gtgatctcat taatattcaa aagcgccttc gcattggatt 2264701 ccgcttttgg cggcttgatc ggtatggcga tttcctgggg cgttaaacgt ggcatttact 2264761 caaacgaagc cggccaggga acaggcccgc atccggcagc tgctgcagag gtttctcatc 2264821 cggtcaagca gggactggtt caggcatttt ctgtttatat tgacaccttg tttgtatgtt 2264881 ccgctacagc tttcatgatc ttgtttaccg gcatgtacaa tacccaggct gcagatggtt 2264941 cctttatcgt tcaccagctt aaaggcgtag aagcaggacc tggtttcaca caagcggcaa 2265001 ttgacagtgt tcttcccgga ttcggtgcag gctttgttgc catcgcttta ttcttcttcg 2265061 cttttacaac aattatggcg tattactaca tcgcagaaac aaatatcgcc tatttagcac 2265121 gaggcagaga aagcaaatgg gcgatgcttg gcttaaaact gattatttta gccgccacgt 2265181 tctatggtac tgtgaaaaca gcttcacttg cttgggcatt aggggatgca gggcttggca 2265241 ttatggtatg gctgaacgtc attgccattg tgctgcttgc caagccggcg ctccttgctt 2265301 taaaggatta tgagcgccaa aagaagcagg gcttagaccc gatctttgat ccaaaagcgc 2265361 tgggtatcaa aaacgctgat ttctgggaga aagaatacac tcatgaaagt gaacgtgtct 2265421 cctgaacata ctaaaaccgg cccgatatga cctcgtgccg gttttttatg aacgatagtt 2265481 tgtatacact tcttgaacat catcgtcatc ttcaaggacg tctattaatg tttccagctt 2265541 ctcaacagcc tgatcatcgg cttctgcata ggtattggga agcatggtca cctccgccga 2265601 agaaattaga tatttcgatt cgagggctgt tttcacctct tcaaaatgct caggctctgt 2265661 gaaaacctca tataggtctt cttcaattcg cagctcttct cctcctgctt caagcacatc 2265721 aagcatgagc tcatcttctt ctatttgccg ttcagtacgg tctatcgtaa tgaacccctt 2265781 tcgttcaaat aaaaaggcta cacatccgct ttctcccaga cttccgccat ttttattaaa 2265841 ggctgtccgc acatttgacg ccgttcggtt tttattatct gttacgcatt caaccatgac 2265901 ggcaatccct gaagggccgt agccttcata ggtgatttct tcatagctgc ttccgtcttg 2265961 gcctcccgca gcttttttaa tggcccgatc tatattttca ttcggcatat tggcgccttt 2266021 tgctttttcg atgacaagac gcaatgctga atttgcttct ggatccgctc cgccttcttt 2266081 cgctgccaca tagatttctt ttgccagctt cataaatatt ttcccgcgct ttgcatcctg 2266141 tgcatttttt cttttttgaa tgtttttcca cttggaatgg cctgccatgt tttcaccttc 2266201 ttttacattt tctatgtaca ctttaatggg aaatgttcgc tgatgcaaag aaaaaggctg 2266261 ccgaatatca cttccggcag cccttccttc ctagcggttg ttcattttat gaagttttct 2266321 gaacagccct ttatctgttg atacttggac gtcacggcca tttgcatagt tgcgcgctgc 2266381 ttttacaaca ttatctctgt cagactttgt gaactctctg tggcttttga ctgcgataac 2266441 tactcggtca tccgatacca taacttgtgt gtcattgacg tttttcactt gtttcacacg 2266501 gttggcaatt tttgcagcca gtcttctgtt ttcttggttg tcatacccgt tgttcgctgc 2266561 attccgattc atgtttcggt tattcgtgtt gttatatgtt ccgtcagttg ccaaaggaac 2266621 acgatcgtca gcagtaacac ggtcacggtt atttacattc gtggtgtttc ggttaccgtc 2266681 gttctgatcc tccattaatt cagaaacagg accatcgtgg tcgattccgt ctccctgtct 2266741 atcggcgtca ttttcatttg tataatatcc gattggacgg gtattgccgt tattgcgcgt 2266801 atcattcata gcattatcgt ttgctccgca tgctgttaag ccggctgtca ttagaatcag 2266861 gctagcgatc gtcatttttt tacccaatgg aaaaaccccc cgtggacgaa ttgagcatgt 2266921 ttgctcgctt ttatcatgtg cgtatggggg gcatgttaag cgtgtcagtt ctctccattt 2266981 ggcagtgatc tgcttgaaaa caaaaaaagg aacgatttac atcgttccga acgatcactc 2267041 attttcttct tccggacggc caaacatttg gtttacagaa ggctggttcg tcattggcat 2267101 agaaactcct gccgaatatg ggtttggatt tgggttagct gtgccatatg gcatattagg 2267161 gcttccataa gctcccattc ccgaatggcc aggtgcagag aaatatggct gatgatcacc 2267221 gtcacagccg cagtcgtcat gatctttgta tggcatgtaa ccatgagccg cagcaggctg 2267281 gtatgctccc attacttggg gagtgccgta ataagggcca tacggcatat gtccatacgg 2267341 agatccataa gccggagatg cgtattgcgg cgcaccgtat gaaccgtaat gtccgtgatg 2267401 gctgttttca tgatgctggt tttcataacc cgggtcatac tgaggcgata caaagcctgg 2267461 ctggtatcca tgcatcggat gcattggata agcttgtgcc ggatagtacg gatagcataa 2267521 tcctgatcct ggaagaattg gcgaaacagg caccggacac ggtacgaaat gagccggata 2267581 atgataataa ggctgaacag ccggcatcgg catattcgga actgtgtgat gaacgttttc 2267641 ctcttctata ccgcctacct ctggcgcctt tggcatatta ggcatattcg gataatttgc 2267701 attttccata ttactcatag cctcctgttg tggaaattgg tcttgcatat gatacatatg 2267761 atccatattt ccgtcatgat gttttttcgg ctcctccggt ttaggaggcg accaaggctg 2267821 gaaaagctgt ttcatatcat aataatcgtt cacatcagct tcagggtaca cattttcctg 2267881 caaattaggc atcggcggga catacggcat ggacttcttt tctttcggct ttgtgtcttc 2267941 tacatcgaca acggatttag gcttctcttt cgcatatgga tgttcttgct tcacactccc 2268001 ggccgcagga cttttgcccg cttttggctc ttttctgacc gggactcctt ctgacggcac 2268061 ttttattttc attccaggca tgattaagtc tggattgcta agctgtgtat tgagtttttt 2268121 cacttcctca acatcgactc cgtacttttc agctattttc cagagcgaat cgcctttttg 2268181 aacgatatgg attttcaacg ttttcccctc ctatgcaaaa cgtgaacagt tcagctgtga 2268241 ttacaatatg tttcttcaca acatatgcct gaacaaaaga agttatgagt aaaggaaggg 2268301 aaaatatttc tgatctacgt gatcgaaagc attcgattca gggcaaggag tgcatcttcc 2268361 tgaatggctt ttggcacctt gatgacgcct gaaggttctc ctttttcaat ttgttccagc 2268421 gaccacaaca aatgcggcaa atcaattcgg ttcattgtca ggcaagggca catgtcaggg 2268481 ttgagtgatt cgatttgttt atctggatgc tcgtgaatga tccgctgaac aagattcatt 2268541 tctgtcccga ttgcccactt gcttcccgcc ggagcctggt tgattgtgtc gataatatat 2268601 ttcgttgatc cgttatcatc gcttagtgtc acgacttcgt gtgaacattc cgggtgcaca 2268661 atgatctgaa tgtcggggtc tcgctctctc atatcatgga tatttttagt ggtgaatttc 2268721 tcgtgaacag agcaatgccc tttccacaaa atcactttca cattcgtatg cccggattca 2268781 gctactaatt catctttcat cggatcccac acagccatat cttcaagcgc aatgcccaga 2268841 tcataagccg tatttctccc taaatgctga tcaggcaaaa ataaaattct ttttttctgt 2268901 gtaaacgccc attcaagcac ttttttcgca ttcgaagaag ttacagttgc tccgccatgc 2268961 tttccgacga atgccttgat ctccgcagtg gagttcacat aagttaaagg tatgatcgta 2269021 tctccaaata tatgctgaag cttcttccat gccctattgg tctgctgcat gtcagccatg 2269081 tcagccatag aacatccagc tctcatatct ggcaggacga ccgtttgctg ctcgcttgtc 2269141 agcatatcgg cggtttctgc cataaagtga acgccgcaaa atacgatata atccgcttct 2269201 ttgttttttt ccgctacttg ggccaattgc agggagtcgc ctgtttggtc agcaaattgt 2269261 atcacttcat ccttttgata atgatggcct ggtataaaga gcctgctgcc gaactttttc 2269321 ttaatggcgg caacgcgcgt ttccatatcc tttctcgata gttctttata actttcgggc 2269381 atcatatcat tcgattgttt gatcacatca agaattgaca taacagcatt cctccacaga 2269441 ttcatttgat aacgtaacat ccatgctgat atctaaactt ttgacggaat gagtcagaaa 2269501 tcctaatgaa atataattca cacccgtccc tttaaaagca ggcaaagatt ctaacgtaat 2269561 cccgccagag gcttcagttt ttatattagc cggtgtgagc tttgcaaaat gacggaccgt 2269621 atcaggcgga cagttgtcaa acataataac atccgctcca gctgcaattg cttcccgcag 2269681 ctgttcctcc gtttcaattt ccacctcgat atttaccatg tgccctgcgg cctgacgggc 2269741 ttttttgcac gcctctaaaa tagagccgca tgctgcgata tgattatctt taatcatgat 2269801 gccgtcatac aaaccgaatc gatgattata cccgccgccg gctctgacag catatttctc 2269861 cagcattctg agccccggtg ttgtttttct cgtgtcacaa attttaatct gttcatcatc 2269921 cagacaccga acagcctctc ttgtcattgt cgcaattcct gacagcctct gaataagatt 2269981 taatacgacc cgctctcctg aaaggagcgc agctgcggga ccgtgtaact cggcaatcac 2270041 ttcaccttta tgcaacatgt ccccatcttt tttgtgtaaa atgctttgaa cattttcgtc 2270101 caataacgaa aagccttctt ttatgatcgc tgctcctgca aaaataccct ctgactttgc 2270161 aacaatctcc gcttcacagc tctgttctcc aaaaatagac tgcgatgtaa gatcccctgt 2270221 cccaatatcc tcaagaaaaa agtgattcag taattttttc agctgtaaat gattcattgt 2270281 tccaaatccc ctcgtttttt ctgatcttcg ttcctttttt tgtatggaca atttgtcttc 2270341 cttgccagct cacctcagca tgaggaaaat cggtgcggaa gtgagcccct ctgctttcct 2270401 cccgcaaaag cgcagaaaac gtcatcagct ttgcagtttg ccatagatga gaaagttcca 2270461 tctgccgaat tgtgatatcc ttcacattta cttcctgaaa aggcagcgta tgaagccaga 2270521 tgctaagctc aatcaaactg ctttgttccc gcagaataga catgtggctt gtcattttgc 2270581 tttgcagttc atgcccctct atatccggca cctcgtagaa gacactggtt tctagccctg 2270641 attgatattg cctgttataa accggttttt ggataatatg ctctgctgcc ctttttccaa 2270701 ataccagcgc ttccaataaa gaattgcttg caagccggtt tgctccatgt aaaccggagc 2270761 atgctgtctc gccaatcgca taaagccccg gcactgtcgt ttctccccag cgattaactg 2270821 aaacacctcc cattaagaaa tgcattcccg gagcaacagg aatttttccg ctgtggatat 2270881 caatccctgc tttttcacaa atagcggtga tggtagggaa acgcgtttca aaatcagaaa 2270941 tcgcactgaa gtctatataa acgcgatttc cttttgccat ttcttcgtga ataacccgtg 2271001 agacaatatc tcttggagcc aggtcaccta aaggatgccg ttcagccata atcctgcggc 2271061 cgttttcgtc tactaaacat ccgccttccc ctctgacagc ttctgaaaca agcccgtagg 2271121 aaacaccatt tttcacaagc agtgtcgggt gaaactgagt aaactccaaa tccgttaatt 2271181 ccgccccggc ccggtaagcc agagaaagac cgtcacctgt gacagtgaga tcattcgtat 2271241 ggtgaagaaa caggtttcca cagccgccgg cagccagcac aacttcgtct gcgtgcctta 2271301 ccttgagccg ccctttgctg tcttttgtca tgacgccgat acatcgtccg tcctctataa 2271361 gcaaatctgc tgccgtttca ttctcgatta acttgatttt gctgttgatc cgtttgagca 2271421 aataatcgat aagcagcctg cctgttgcgt ctccgcctgc atgaaatatg cggttgtatg 2271481 agtgggcccc ttctcttcca agacaaacac cgcctcgttc attgcggtcg aatggaaatc 2271541 cacgctccaa taggctttga accatcattt ttccatcatg taatacgtct gctacaatag 2271601 ctagattatt atggccgcac cctgcgtata acgtatcctc cagatgggct tcaatcgagt 2271661 catcttttgc ataggccgca gcaatcccgc cttgtgcata gacagaattg ctgtttttga 2271721 cgcttttttt tgtgataaca gtcacttcgt atgagggcgg gaaagctgca gctaaggaaa 2271781 gtgccgccgc ccctgaaccg atgactgcaa tcgtcttttt agacatatgc catcctcctg 2271841 ttgtttacac ctgtcttgac acctatattt acacaaggat aaaataaact caagagtttt 2271901 ttatggagaa cggatggagg aagaccggat gatttattta gattatgcag cgacaacgcc 2271961 tatttgtgag gaagccctta ctgtatatca gaagcttagt atggatatgt acggaaatgc 2272021 cagcagcctg catgatgcag gaggaaaagc aaagcacata ctggagtact gccgtgaaaa 2272081 aatcgccaac atcattggcg gagaagcaag cggcatctat tttacaagcg gcggcactga 2272141 atccaatttt ctggccattc aatcattgtt aaacggcctg ccaaaaacga aaagacattt 2272201 tattacgact gccatggagc atcagtccat tcataattgc gctgcttttt tggaacagca 2272261 gggatatgat gtaacagtca ttgaaccgaa tgaatacggg cttattaccg aggaaatatt 2272321 actaacccat atccggccgg aaacaggcct tgtatctatt cagcatgcaa attctgaaac 2272381 cgggatcatt cagcccattc aacacctgtc ttcatacctg cacaataagg ggattcttct 2272441 tcattgcgac gctgttcaaa cgtttggaaa gatcccgatc aatacaaaaa atctgggagt 2272501 agatgcactc tcaatgtcca gccataaaat ccacggtcct aaaggagtag gggcggtcta 2272561 tatccggccg gatgtccctt ggaaacccgt ttatcctctg actactcacg aatacggatt 2272621 cagagccggc accgtaaatg ttcccgggat cggtgccttc actgccgctg cagaattgat 2272681 cgtaagcgaa atggaaaaac agatatcccg caatgaggca ttaagaacat actttctaga 2272741 ccaaatccgt attcggtctc tccctgtaac ccttgcagca gacacttcga aagcagaatg 2272801 tcttccgcat attatagggt gtttttttca ctcatttgaa ggacaatatg ttatgttaga 2272861 atgtaatcgg agtaatattt gcatttcaac cggcagcgct tgttctgcag gttaccacgg 2272921 tccgtctgaa acaatgaaag cattaagaaa aaccgaacaa gaagctctgc aatttatccg 2272981 catctctttt ggcaggcata caacagctga acagctggaa cagttattac atacgtttac 2273041 agtgctttgg gaacaaaaga aaggagaatt tgatattgac cgaagaatta aagctaatgg 2273101 gcgccaacag gcgtgaccag cttcttctgt ggctgaagga atctaaatca ccgctgacag 2273161 gaggagaact cgcaaaaaaa gcgaacgtct caagacaggt tattgtacag gatatatcgc 2273221 tcttgaaagc gaaaaatgta ccgattatcg ccacaagcca aggatatgta tacatggatg 2273281 cagccgctca gcagcaccag caggcagaaa gaatcatagc atgtctgcac ggtcctgaac 2273341 ggacagaaga ggaactgcag ctcatcgtcg acgaaggcgt tacagtaaaa gacgtaaaaa 2273401 tcgagcatcc cgtatacgga gatttaactg cagccatcca agtaggcacc cggaaagaag 2273461 ttagccattt catcaaaaaa atcaattcta cgaatgctgc ctacttatca cagctgaccg 2273521 acggcgtgca cctgcataca ctgacagcac ctgatgaaca tcgcatcgat caagcctgcc 2273581 aagccctcga agaagccggc attttaatta aagactaaaa aaagccctct agtgggcttt 2273641 ttttataatt ggtaagactg gtatgcaccc agaagcctca ctttgcagcc gagtgcttca 2273701 agctcctgca tggcccctgg aatcaataca tcatcaaacg ctttctcaat atcaataata 2273761 aagaaataat ggcctaatcc ggttttagtc ggacgtgact caatttttga caggtttaaa 2273821 tttctccaag aaaatgcaga cagcactcta tgcagcgccc cggactgatc atcctgcggc 2273881 agcatgacca ttaaggtcgt tttgggccta gagctcaatt ttgaattcac ttcaaaagat 2273941 atgttttcat cgggagacag gataacaaat cttgtatgat tgtccctata atcctgtata 2274001 tcccgtttca cgatttttaa ttcgtatgta gaagctgcca tatcattggc aatgaccccg 2274061 atattcagct cgggatggtc actgacaaac tttgctgccg ccccggtaga attggcgtat 2274121 tcatatggaa cggaaggaaa atgtcgatga agaaatttat ggcattgcgc aatcgcgtgt 2274181 gaatgtgagt aaattttgtc gagctctttc catgcattct ctcttgaggg atggacgagc 2274241 aagtgctggt gaatcggcaa cgtcatttca cccacgattg gcaaaggctg ttcatgtatt 2274301 aaatagtcta ttgttagatt aacagatcct tctaaagcat tttccaaagg aacaaaagca 2274361 aaatcaactt cgcctgcaac ggctgcatct atacactccg gaatggtgcg gtaagcaaca 2274421 tgttcggcgc cgttttgaaa acaagaactg actgctagat gtgtaaatgt agctgctgga 2274481 cctaaataac cgactttcat gacgattttc tctcccttat gcacctgaac ctaatatttc 2274541 aaccttttct acaaaatcaa acttcctgag cttattcatt aatgtatgaa tgtcttcttc 2274601 cattgccgac gtactgatag acagtgtcac atttgctctg ccttgaagcg gaatggtctg 2274661 gtgaatggaa agaacgttgc ttccagaatc agctaccgcc tgaagaagct gagataacgc 2274721 acctgaccta tcctccaaat gaaagaaaag tgtgataatt tgttctttta ccatggtgta 2274781 gaatggaaaa acagcatccc tgtatttata aaacgcactt ctacttaaat cgaccttttg 2274841 aacggcatct gctactgaat ctgctttttt tcgatcaagc agctttttga cttctaatgt 2274901 ttttctcatt gcatcgggca atacatcttc acggacaaga taaaatgtct cctctttcat 2274961 ttgcatcccc cctttaaaat agagagcctg gcaccaggct ctcttttcag ccaacattga 2275021 ttaatcaata aattcaaatt caaattccag aagcctgatt atatctccat ccttggctcc 2275081 gcgttctctg agtgcttcat caacacccat tccgcgcatc tgtcttgcaa accgtttaac 2275141 cgattcatca cgtgagaaat cagtcatctt gaataaccgc tcaaggctgt ctcctgaaag 2275201 cacaaataca ccgtctggat cgcgtgtaat gttaaatggc acttcttcat tttccatcgt 2275261 gtacatgaca cggttttgtg taagctcttc ctcgtcatac agcgggaatt ccggtgtgtt 2275321 ctcaagctga ttggcaacct caaacagaag ctcacgcaga ccttctcttg tcaccgcact 2275381 gatcgggaat accggataat catccgtcag cttttcttta aaggcttcga gattttccgc 2275441 agcctccggc atgtccattt tatttgcaac gataatttgc ggacgctcag tgagacgcag 2275501 attgtactcg ctcagctcct ggttaatcgt aagataatca tcatatggat cacggccttc 2275561 taagcctgac atgtcaatga catgaacaat aaccctcgtc cgttcaatat ggcgcaaaaa 2275621 ctggtggccc agtccgacgc cttggtgtgc gccttcaatc agccctggca aatcagccat 2275681 gacaaagctg cgtccgtcat ccgtttcaac catgccgaga ttcgggacaa gcgttgtaaa 2275741 gtgatagtcc gcaattttcg gttttgcaga tgagacaaca gacagcaaag tagattttcc 2275801 cacactcggg aacccgacaa gtccgacatc tgcaagcact tttaattcaa gaacaatgta 2275861 gcgttctttt cccggctcgc cgttttctga aagctgaggc gcgggattag ccggtgtagc 2275921 aaagcggcta tttcctcttc cgcctcttcc gcctcttgca atgacagccc gctgtccgtg 2275981 ctctgttaaa tcagcgatga cctgttttgt atcatcgtct gtcacaacgg tgcccggcgg 2276041 aactttaatg accatatcat cagcatttcg cccgtgctgg tttttggaca tgccatgctc 2276101 gccgcgaatc gctttaaagt gttttttgta tctaaaatcc atcagggtgc ggagaccttc 2276161 atctacttca aaaacgacgt ctcctccctt tcctccgtca ccgccggcag ggccgccttt 2276221 cggcacatat ttttcacggc gaaacgcaac cataccgttg ccgccgtcgc cgccttttac 2276281 atatactttg acctgatcta caaacataat gtcctccgtt ctaaaccgtt aaaaactccg 2276341 ctagtccaac ccaatttcaa tcagacattc gtgactcgtg atttcaaaac gcatgatatc 2276401 aacgtcctca tatccattct gccgaatatc atcaaaagca gatggatcgg caaaggcgcc 2276461 gtgaaaatca aggtacagaa tcagctgtct gtcaggatga tccgtttgaa gcgaaaccgt 2276521 taaatgattt tcactctctc tgctgactgc ttgatcaaac agatgaaaca gctttctcat 2276581 cagtttcgcc agcttttgat cataagccga caaatcctta atttctccga gaacttcata 2276641 ttcaagcgtc atataatggg ttttccaatt aaacgtaaga aaatcaaacg ccaaatgcgg 2276701 tgttttcagg tttgagagct ttgattcgtg ctttgcgtct ataaccattt cttcaatcat 2276761 ttcaaagaca cggtcatact tctgtaagct taagtttcct ttaatcagct gcagcttatt 2276821 catccaatca tgccgggaat ggccaagcag atgaatcagt tcgtttgtta atgccgtgtc 2276881 gcttatattt tcttcttgat tttttgaaac atccttcatt ttcgcactcc caatcattta 2276941 atttcttatt taggagtctg tataagtgtg tattatgaat tataacagag aaggctttgt 2277001 tagaaaaaca attgtttttc ccagaaatat catgttcctt ttttctggct ttggttgatt 2277061 tgcagccagg cagaacattt tatgtattac tgcttgggga acatatccag tgggtttgag 2277121 atgtttattc tcattcttgg cggggtctgc tcgcacatac tctgcatttc attctaggtg 2277181 tttactccgc atattgcaaa aaaaactcca gtcatcatcg accggagttt tttgaatcat 2277241 tattgagcta caggatatac gctcactttt ttgcggtcac ggccgaaacg ttcgaattta 2277301 acagttccgt cgattttcgc aaatagagtg tcatctccgc cgcggcccac gttttcacct 2277361 gggtaaattt ttgttccgcg ttgacggtaa aggatagaac cgcctgttac gaattgaccg 2277421 tcagcacgtt tagcacctaa acgtttagcc tcagagtcac gtccgttctt tgtagaacct 2277481 actccttttt tagaagcgaa aaactgaaga tctaatctaa gcatgtagct cacctcctat 2277541 attatgtttg tggtcacacg caagttgtct ttgtaatccc gttcgattgt ctccagcgaa 2277601 acaatcatgc cttcaatcag cagctgagct ttttggcgtg cctctggatc aagagattca 2277661 gggaattcaa aataaaaata acccccgtcc tctcctatat caagaagcgg ctcgaagccc 2277721 gcgagcacaa tgaccgcgtt aacggcccca aacacaacgg ctgtcactcc ggcacaaaca 2277781 agatcttgtc catgttcagc aaaattcgca tggcccgtca tttcaaaaga caatatgcct 2277841 ttatcatgag accttctgat tgttgcctga atcatgctta cgcgttgatt ttttcgatcg 2277901 tcactttagt gtaaggctga cgatgacctt gttttttatg aacgtttttc tttggtttgt 2277961 atctgaaaac agtgattttt ttcgcgcggc cttgtttttc aactttagcc gttactgttg 2278021 cgccttcaac tgtagggttg ccgactttca cgttgtctcc gccaacaaac aaaacgtctt 2278081 caaaagtaac tgtttcacct gcttcagcag caagtttttc gatgtaaaca gtttggcctt 2278141 cttcaacttt gatttgttta ccgcctgttt taatgattgc gtacattctc tgcacctcct 2278201 attagactaa gactcgccag ataccagggg gctgtaaaag ctcttaacac ctgtactgag 2278261 cggttgtagc aatggtgcta catccataac attaaaaaat ataccaaaat acaaggcgtt 2278321 tgtcaatcag ttttagtagg gcagaagcag ttcctccatg gaagaattcg tccgcttatc 2278381 ggcaaagtaa gcgtgcagca cttcattctc gtcaagctgg ctgagctttt ggcctgattt 2278441 ttctataata atcggatgct tacagccacg tttgaactcg gccatcacat gatagacttt 2278501 atcctccgcc tttactgtca gcggcagaag tttctcaagc tccctgtttt ttccgtaata 2278561 cctttcgagg agaaatctca catggatata gtgcctttgc cgatattcct caaacaagga 2278621 aacagccaga aagacaaaca aaacccatgc gctgatttgc agaggaatca cgaataaaac 2278681 ccagcacccg agcagcaggc agaagcagag cgacgttttt agattaagcc ggtgagcctt 2278741 ttgaaaaggc agctgtttgg aaaacaacaa aaataacagt tttcctccat ccagcggcca 2278801 gatcggcagt aaattgacaa ataagataga aagattataa aaggtgaaga gttcaaaggt 2278861 atgctgatga atcactgaga cttctgcaag catccaggcg gcaaactgaa gccagatgtg 2278921 ctgaagaggt ccggcaataa tgaccgcaaa ctcttccttt aacggccgat tcccgtgctc 2278981 ttccacttcg accgttccgc caaacggcag caaaaaaaca cgcttgattc tccaagaaaa 2279041 aaacacagcc agagcagcat gccccagctc atgaatcaat acaatcagga gcagacataa 2279101 taatgctttc atatggcctg tgagcaagcc cagcgccgca ataatccaaa gaaaaggatg 2279161 cacatggatc tttaagataa ggtcgagcca tttattcaaa tgaaatcacc tgaatcggat 2279221 caataaattt atcgccgtct ttcatggcaa aataatagac ccctttatta tgatcatcaa 2279281 gcttaatcga accgagcttt ttgcctttat ccacaaaatc atataaagca acatccacat 2279341 ctttgagctc gccatagata ctataggtgt tgtcagcatg ctgcacctta accgtcagtc 2279401 ccgtttggct gtctttgctg acttcaacca catagccttc ttttacgcta tcaatcttat 2279461 cactgcttgt ttcgacttta attccttccc cattgtcctg aaaatcctgc tgtactttcc 2279521 cggatgcagg cgcgatcaga tctttgccta cttcaatctg ctgttcctta tttttgtgtt 2279581 caggagccag gaaagcaagc ggatttccga atttggtttc gaaccaatgg cttgctgaag 2279641 caaattgaaa ttcagtttca aaggttttgg ctacggcggg tttaatctga ctgacgggtc 2279701 caatgtttgt tttataggct atagctgaaa cgagaacaag gcaggccgac agaagacatt 2279761 tcaggataat tgaatctgtt ttcaccaatg ggtgttttcc gttgaatgtt ggcatgttat 2279821 cttcgtagac cggaagtgtt ccatgctttt cctgatccgt taccatcacc caggacgggg 2279881 gtttctgctt ttcagaaact gtctgagtag agaaacgttt tgagccggaa agctgctttc 2279941 ttcttttctc taatcgtttt ctgatttcat ctgctctgtg actcattgcc atcatccttt 2280001 gcattcgttg ggtttgtaca tcatatgtct tgtccatggc aaatattcgg tttagtcaag 2280061 aacaaagcag gcaaaaacaa aaaaaacctg acacagcata tgctttgtca gattcttctc 2280121 tttgattcta tcacattaag atcttactcc gaaaaatgac ttaatcttag ccatcattcc 2280181 tttgttttgc tcttcaagca cctgtaaagg aacagattca cctaagatgc ggcgggcaat 2280241 attgcgatat gcaatggaag cgcggttttt agggtccatc gcaatcggtt cgccatgatt 2280301 ggaagcttta atgacttcat catcatcagc cacgattccg agcaaatcga tcgacagatg 2280361 ctgtacgatt tcgtcgatat ccatcgtgtc accgtttttc atcaggtgat ttctgattct 2280421 gttaacaacg agccgcggcg gttcaatatt ttcctcttgc tccagcagtc ctataatacg 2280481 gtcagcatca cgaacagctg agatttcagg cgtagtgacc acaatcgctt tatcagctcc 2280541 ggaaacggca tttttgtacc cttgctcgat tccggcagga cagtctatga tgacatagtc 2280601 aaattcctgt ttgagctctt ggaccatgtt tttaatttgt tcaggagcaa cagctgtctt 2280661 atcgctcgtt tgagcagcgg gcattaaata gagcagatca tcgaaacgtt tgtcttttac 2280721 gagcgcctga tgcattttgc atctgccctc tacaacgtct accagatcgt aaataattct 2280781 attttcaaga cccattacaa catcaaggtt gcgcagtcct atatcagtat ctactaagca 2280841 tacgcgcttc cctaaaatgg ctaaggcggt accgaggttc gcagatgttg ttgtcttacc 2280901 tactccgcct tttcccgaag ttattacgat agcctcaccc aattcacatt cctccctcaa 2280961 gccttgttag atcaggtctt aaatgagcca aatgttgaag gcgttcaatg accatatttc 2281021 cgtctgtatc taaataagca cattccattt cgttcccttt ttgaatgtgg tctggggagc 2281081 gatttaacac atgattgatt cttaattgtg tcggaagcat ttcagaggcg gcgatgaccg 2281141 cttgattatt tccattgaat ccagcatgcg caattccttt cagtgagccc agaacaaaaa 2281201 tgttccctcc ggccctgact gttccgccgg gattcacgtc accgatcagg agcaagtcgc 2281261 cttttacctg cagcacttgg cctgaacgga caatttttga aacagaaata atttcggctt 2281321 cctctcttat ctgctgtgct tcttttttag taatgacttc actgtcaata gaatgaacaa 2281381 acaaatcttt ctttgacgca atcaattcgg ttagctgttc ctcttgctcc ttatataaaa 2281441 agcgatttcc cagcttaaca tgaacgctga ttttctggcc ttttccatcg gtatattgtt 2281501 caattgacag catattctga agaccatcga gaagctcatc aaaagaacac gcatcatcca 2281561 gatgcaatgt tagtccattc tttgttcctt ttattgttac atattgctgc tttttggtct 2281621 tcacaatatt cacctcaaca acatactcat ttcgtcaaaa aaagataaaa tcctttttac 2281681 tcatctctca attctttctt tagactcata aaaaacaatc taaatggcag aacaagaata 2281741 agagctgctg caatatttaa taaaattgtc ggtataaacc ggtcaagcac aaatccgtta 2281801 aacgtcataa tgtctttatg aatcaaagac tgaatgccga atacgtaaaa ttcgagcaga 2281861 cagacagcca gaactgctat caatatcact acaaatgcgt ttgtatgcaa cactttaaac 2281921 gcttttgaag ccaaatagca tagccctgca aaaccaaaca tgtaaacgcc taatagactt 2281981 gtatagttca tgtcatatag aaagccaaaa ataaatccgt aaatcatcgc gtgtttttgg 2282041 ttgataaaag ccgacatgaa tatcaataca agcatcaaaa aacgcggggc gagcacttgg 2282101 tcatctgtaa cgaaaggaaa atgcaccaaa tctgtaaaaa tgctttccgc agaaaaaaca 2282161 agcatcataa cgaaagggag aaggaaacgt ttcacgatcc ttcctcctct gtatcgacag 2282221 tcggcacgtc acggttaaca acgatcacat tatttaaatc tgtaaggtca gccgcaggtt 2282281 ttacataagc aaccttcgtt aatccatagg aatctgactc gatatcagtc acttcaccga 2282341 ttgtcagccc ttctgggaaa acaccgcctg tccctgatgt ttcaataaga tcgccttttt 2282401 tcacgtcttg tttatcctta cgctcaataa ttgtcatctt aagacgtttt ttctctttgt 2282461 catatccttc gatcaagccg tagcctttgc tgcctttttt tccggaaatt tttgtcgcga 2282521 ctctgttatt gcggtcagta tcgcttaaaa gctgaacagc agacgtaaaa ttgttaagtc 2282581 cggagctttt gatcttgccg attaatgcgc ctttttcgtt tgtaacggcc atatctttcg 2282641 ctacgttttg ctgagtcccc ttgttaatgg tgacctgttt cgcccaatta tcagggcttc 2282701 tggcgatgac cgttgctaaa atcggcttgt aatctttaat cgatttgaca tggccaagct 2282761 cgtcacgcaa ggatttgttt tcttcttcaa gctcttgaag cttggcttca tattgtgtct 2282821 gtccgtcaag tttttctctt agacgctcgt tttctttgta tgtgtttttt aaatcattga 2282881 tgttctcaaa tattcctgca aaaaattcgg caggcgtatg aaaaatattt tgaaatactc 2282941 ccgtcgtatc gccgatcact ttctcaggcc aggtggtatt gcggccgccc ttcagcgaaa 2283001 atccaatcat agccaccaat atgataatac acagaagtaa tagcattaac cgcttattcg 2283061 gcatcgtgtt acacctcttc tattgaactc ccgattatct agttttccct ttgaaaagat 2283121 ggatgtgctc cagtgctttc cctgttccga tcgctacaca atcaagcgga tcttcggcga 2283181 taaggaccgg catttttgtt tcttcgctga tgactttgtc caaattgcgc aaaagcgctc 2283241 cgccgccggt taacactata cctctgtcca tgatatctgc tgcaagctca ggcggtgttt 2283301 tttcgagtgt gctcttcact gcttcgacaa ttgtagatac agtgtcgcgt agagcgttag 2283361 aaatctcttt tcctgtaatt tcaattgttt tcggcaaacc tgtgagcaaa tcgcggccgc 2283421 ggatttccat gttgtcggat tcttcaggag cttctgcaga tccgatttcc attttaatcg 2283481 cttcagccgt acggtcaccg atcatcagat tgtacgtttt tctgatgtag ttgataatcg 2283541 cgtcatccat ctcatcaccg gctacacgga ttgactgaga cgttacgatg cctccgaggg 2283601 aaataatcgc aacttctgtc gtaccgcccc cgatatcaac aaccatgctt ccagtcggtt 2283661 cccaaactgg cagattggct ccgattgctg cggcaaaagg ctcttcaatc ggatacgcgt 2283721 cacgcgctcc cgcctgtctt gtcgcatcga taacagcgcg ttcttcaaca gctgtaatgc 2283781 ctgatgggac acataccatt acatatggtt ttctggcaaa catgccttta ttttttatgg 2283841 cctgattgat gtaatatttc atcatcgtcg ccgttgtttc ataatcagcg ataacgccgt 2283901 ctttcatcgg gcgaagagcc accacgttgc ccggtgtccg tccaatcata tttttcgcat 2283961 catttccgac agcgacaatc gatttcgtat ccgtctgcaa agcgacaact gacggctctc 2284021 tcacaacaat tccttttcct tttacaaaaa caagcgtatt cgcagttcca agatctatac 2284081 caaggtctct agcaccaatt ccaaacatat gtatgtatct tcctttctta aagcaaaaat 2284141 accctaaagg gaaaaactca taaactctat tatagcttaa ttcgacgaaa aaaaaagtgt 2284201 tacaaatatc ctttttcctt taaactcaca aattttttat ccccgatcac caaatggtca 2284261 agcagctcga tgccaatcag gtttccgcat tcaaacagcc gtcttgtcac ttcaatatct 2284321 tccctgctcg gcgtcggatc tccagaagga tgattatgaa cacagataaa ggaagcggca 2284381 gatcgtttaa acgcttcttt aaacacctct cgcgggtgga caatagatga attcaggctt 2284441 ccgataaata cggtgcgttt atggatgact tgattttttg tatttaagta taaacagaca 2284501 aaatgctcct gggttaaaaa gcgcatatcc tccatgacaa gattagcgcc gtcttccggg 2284561 gagcgaataa cgaaatgttc ttcgttggct aatttatgaa tccggcttcc aagctcaact 2284621 gctgccagta tttgaatcgc ttttaccata ccgattcccg ggatgcttga cagctcttca 2284681 accgatgctt ccttgagcag gcgcagcccg tcaaatgagc gcagcagccg gtttgacagg 2284741 tccaaaacag attcgtgttt agtccctgtc cgcaataata tagccaaaag ttcatgattc 2284801 gctaagttct cggctccgac tttcaggagc cgttcccttg gcttttcttt cattgggaaa 2284861 tctttgagtt ttaatggcag atcgtgtatg accaagcact ccttttcttt cccttcccgt 2284921 ttatagaacc gtcatgccct tatatcaaaa tggcgaagag ctctcattgt ttttgatata 2284981 ggaaggccca tgactgaata ataatctccg tctattttct ttacaaaaag cgcgcctctt 2285041 ccttggatgc cgtatgcacc tgctttatcc atcggctctt ttgtttcaat atatgtccaa 2285101 atctcttctt cactgaggga ccaaaacgca acttctgtct tatcataaaa agtctcgctg 2285161 tgattttcag cttgaatgct gaccgcggtt attactgagt gacttcggcc tgaaagcctc 2285221 cgcagcatag aagcagcttc ttcttgatcc tgcggtttgc caagacattc gccgtcaagg 2285281 cataccattg tatcagcacc gataacgatt gcatgcgggt ggagatcagc tacagcctta 2285341 gctttttgtt ttgccaacca ttggacgttt tcttctggtg aaaagtttcg atttaatttt 2285401 tcttctactt cactgacaat aatggagtag ggcagctgga gaagatcgag gagttctttc 2285461 ctgcgcggag attgtgatgc aagtattagc ggttttgtca tgttcgtcat cctttcaggg 2285521 tttgcttaag aaaaaaagat actcgtttat cctaccaaat cacgaggctt gtcacaattt 2285581 cagaaaaata actttttcat gacaaaataa aaaaagcctg tcactaaagg acgaaggctc 2285641 agggcactat ctcttatttt acgacggcta acagctcctg ctgagccttc cacccggctt 2285701 cagcacttgg atcctctaat tcctttaaag cctgcaaaat cgcttttttc tctcctgttt 2285761 ctgacgcttt tgtttcacca agcgactttt ctattttctc tacactcgct tttgtaatgt 2285821 cttcgtcgag aatcgccttt gctgcaagct ccgctgtttc cttaaaagaa tctgtcatat 2285881 ctgactctat tgataaggaa agctccttgc ctccccaggc ttcaaaatca ctgtcgatta 2285941 aaacctgtcc taactgctgt gagacctcct tttcacttgc taagcctgca ataacatacg 2286001 tatacccgtc atcctttgac agtgacacgg cggaatatcc tttttcggtc aattgttctg 2286061 ttaacgtttc ggcgcccttt tcatttgaaa attttccggc ttgcacagcg tatgttttgt 2286121 atgtaccttc agtttgtgcc gcttgttttt ctgcgcctga ggtttgttta tcagcagaag 2286181 tatcccctgc ttttgccgtt tggctgccta aagaatcctc taaagaggcc ggtgctgacg 2286241 cttctttatt ccccgatatg tttaacgcga ataaccctaa tccagtgcca atgacagccg 2286301 cgaaggcaat cgtcgcggcc actcttttta ccggtttggc agccccggtc tttccttttg 2286361 cgtaaagctt tgtttttttc ttttgaaaag gaggaacaac tttagggtcc tctttaaaca 2286421 ccttgtcctc ctcggaatcc caattgaatt catcttcatc agggtgttcc tgggatgccg 2286481 caacctcttg ttctgcctgt cttttttcct cccaatttga aaatgtcatg cttttattcg 2286541 cctctgtctc aggcgtctct tgttcgtaaa ccgtctcttc ttttccatta atcgtcacct 2286601 tgagggcttt ttctgcggct ttactgtttt ttttattctt tctttttttc aattccgctt 2286661 cctcccttca tttgcttgac cgttcttgtc ggcttttcat gctacacact ttagcacagg 2286721 caaagaaaaa aagaacaaga cttttgtcgc cttgtccaaa aaacgttcgt caaatttttc 2286781 agcagtcagc ccaatgccat tttgatataa aaagaaatga tagagtcacc gtataaatag 2286841 gctaaaatgc tccctgcggc tatagcgggg gcgaagggaa gcggctgcct tttagcgagt 2286901 ctaccagtca gaacagctgc cgctccatat aatgcaccta tcaaaactga aaagaaaaag 2286961 gcagctgcca gcattttcac accaagcaca aagccaatca ccgcaaataa tttaatatct 2287021 cctcccccta ctcccccatg ggtgattgcg gcaattacag ccagaaacaa aaatccggct 2287081 gccgcaccta acaggcctgc ataccaggaa tcaagcggag aaatcaatct cgcggccgcc 2287141 aaaaagggaa gaaagaaaat caatattcga tttggaatca gcataaaatg aatatctgtc 2287201 actgcaacaa taatgagaag agagataaac accacagcgg gaaacagttc cagcgatatg 2287261 ccaaagcgta ttcctgcggc ggcaaataaa cacgctgtca caagctctgc tgcgggatac 2287321 ataaaagaaa tcctatgccc gcagctttta catttacctt tttgaaatag gaatgacagg 2287381 atgggaatta attctgcagg agttaatgtt cgccggcaaa acgggcatga tgaacggggc 2287441 gcaataatag atagatgtaa ggggatacgg cacccggccg tatagtaaaa agaaccaagg 2287501 ataagcccga agataaaaag aatggatagc atagacaaca cacctttact cattgagttc 2287561 tggtatggat tgtagcaaaa tggacatcct gagctccaat tgggaatatt caattttaca 2287621 catgaaaaaa acggcagaat ctttttttga ttctgccgga gccggatgct tttatttcaa 2287681 cctttttcga atgtcagaaa taaagtaaag agatccggta atcagcacaa tttcatttga 2287741 gcccttttta ctttctatga atttgattac atcgtctgga tcttcactcc agcttttatt 2287801 gctgatttca cttgcatcat agagatcttt tgcaagggaa gcacgcggga aatcaaaaga 2287861 agcaaaatga atcgcatgag caatggtttc cagtctttta atcatgttct gatacggttt 2287921 gtcctttaac gcgctaaaca ccacagaaat gcgtgaattg gcgaaacgct gcttcatcgt 2287981 ttccgccagc ttttcaacac cttcttcgtt atgcgcaccg tctaaatata ccggaggatg 2288041 ttcctgaaca agctctaacc gtcccggcca agcagccttc acaagcccgc tccttaacgc 2288101 ttcgtcactg atatgggcga tattctcctt attgagccac tccgcagcca aaatggacaa 2288161 agcagcattt tgtctttgat gggtgccaat cagagatgtc cgaatatctt catagcattt 2288221 ctcttccgtt ttgaatgaaa actgttctcc tgcaggcaga gcctcttcat tgaaaataac 2288281 acatgcatca tgcaatgact ggaacggcgc agcatgccgt tcggcttcat ggcggatgac 2288341 ctgtaaagct tccggctggg taactgctgt aacgattgga ataccttctt taataatgcc 2288401 ggccttttct cctgcaattt cttcaatggt gtttcccaaa atgttcatat gatcgtgtcc 2288461 gatgcttgta atcacagtta agagcggttc aaccacatta gtagaatcga atctaccgcc 2288521 cagacctgtt tcaaaaataa caaaatcgac cttatgaaac tctgcaaaat ataaaaatgc 2288581 acaagctgtc ataatttcaa attctgtcgg ctgtccgtat tccgtttgat caagggcttc 2288641 aacgtgcggt ttcatttgat tgacgagtgc tgtccattcc tcatctgaaa tcggtatccc 2288701 gtttacgctg atccgttcat taaacgtaat aatataaggc gatgtaaatg ttccaaccgt 2288761 atatccggct tcctgcagca tagaacggat aaaagcgaca gttgatcctt taccgtttgt 2288821 tcctgcgacg tggaacgctc ggattttttt ttcaggatgt cctaaccgcg ccatcagctg 2288881 tttcattcga ccaagtccgg gcttcacccc gaatttcagc ctcccgtgaa tccagctgcg 2288941 cgcatcttga tatgcagtaa acaatgataa tcccctcttt tataagacaa ggcggtttct 2289001 ctagaaaccg ccccggcttt tcattaaccc ttcagctcag ccattcgttt ttgaacagcg 2289061 tcacgcttcg ccacataatc tttttctttt tcacgttctt catcaattac gtgtgcaggc 2289121 gcttttttca taaatccttc atttccaagt ttcttttgga cacgctcaac ttcttttgtc 2289181 agtttatcaa attctttttg cagacgggca atttcttcat caatattgat taagccttca 2289241 agcggaagaa taacctctgc tcctgagaca acggccgtca tcgccttatc aacagcctca 2289301 atatcggtgc cgattttaag cacgctcgga ttcgtaaagc gttcaacata tgaacggttc 2289361 gcttcgaggc gggacgctat ttcgtctgtg cttgttttaa tgtacagttc aacctgcttg 2289421 ctcattggcg tattgacttc actgcggata ttgcgcacag aacggatcag ctcaacaaga 2289481 agcttcatgt cagctgccgc ttcagtatcg gtatgctccg gcactactgc aggccattga 2289541 cttactgtaa tcgattcccc ttggtgagga aggtgctgcc aaatttcctc cgttaagaat 2289601 ggcataaacg gatggagcag acgcatcgtt tgatcaagta cgtaagcaag gatggaacgg 2289661 gtagttttct tagccgcttc gtcttctcca taaagcggaa gcttcgccat ttcaatatac 2289721 caatcacaga aatcatccca aataaagtta tataaatggc gtcctacttc accaaattca 2289781 tatcggtcag caagctgggt cacgtgctcg atcgtttcat ttaatcgcgt taaaatccac 2289841 ttgtcagcga ctgacttttc acctgacaga tcaagctcat cgtacgtcat gccatccata 2289901 ttcattaatg caaaacggga ggcgttccaa attttattgg caaaattcca ggtcgattcc 2289961 actttttcat agctgaagcg cagatcctgg ccaggagagc ttccagtcgc aaggaaataa 2290021 cgcagagaat cggctccgta cttgtcaatc acatccatcg ggtcgacacc gttgccaaga 2290081 gatttactca ttttccggcc ttgctcgtca cggattaagc cgtggattaa aacatctttg 2290141 aacgggcgct cgcctgtaaa ttcaatgcct tggaaaatca tgcgtgatac ccagaagaaa 2290201 atgatatcgt accctgtcac gagaacatct gtcggatagt agcgtttaaa gtcttcagcc 2290261 gttacatcag gccagcccat tgtggagaaa ggccatagcg cagaactgaa ccatgtatcc 2290321 agtacgtctg tatcctgttc ccaattttcg ctgtcttccg gcgcttcaag tccgacatat 2290381 agctcgcctg tttctttatg ataccaggca ggaatacgat ggccccacca caattgacgg 2290441 gagatacacc agtcgcggat attttccatc cagtgtaaat acgttttttc gaaacggtca 2290501 ggcacaaagt tgaccttttc ttcttttttt tgcagctcaa tcgctgcatc agcaagcggc 2290561 tgcatgcgca caaaccattg tgtagaaaga taaggctcca caacagcccc gcttcgttca 2290621 ctatggccga cagagtgcat atgatcctcg atcttgaaga gaactcccgc ctcctgtaaa 2290681 tctttcacga gctttttgcg gcattcaaaa cgatccatac cttgatattg gagcgcattt 2290741 tcattcatcg tgccatcttc attcatgaca aggatgcgtt ctaaattgtg gcggttgcca 2290801 agctcgaagt cgttcggatc atgagcaggc gtaattttca cggcacctga accaaattcc 2290861 atatcaacat agtcatcacc gacaatcgga atttcacgat ttacaatcgg caggatcacc 2290921 gtttttccga taaggtgttt atagcgctcg tcttcagggt gaacggcaac agctgtatca 2290981 ccgagcattg tttcaggacg tgtcgtcgca atttcaattg agcctgaacc gtcagcaagc 2291041 ggatagctca tatgatagaa tgcgccttga acatccttgt aaatcacctc aatgtcggat 2291101 agggctgttt ttgtcgctgg gtcccagtta ataatatatt cgcctctgta gatcaggcct 2291161 ttttcataaa gcttaacgaa tacttccctt accgctttgc tcaagccttc atccagcgta 2291221 aaacgttcac gggaataatc taggccaaga cctaatttcg cccactggct gcgaataaag 2291281 tcagcatatt cttccttcca cttccacgtt tcttcgagga atttttcacg gcctaaatcg 2291341 tagcgggatt tgccttcttc acgaagtttc gcctccactt tagcctgtgt cgcgatgccg 2291401 gcgtggtcca tgccaggaag ccacagcaca tcatagccct gcatgcgttt cattcttgtt 2291461 acaatgtctt gcagcgttgt gtcccatgcg tggccaaggt gaagtctccc tgttacgttt 2291521 ggcggcggga tgacaacaga gtatggctct tttgtctggt cactgcccgc ttcaaaaaat 2291581 ttgcctttta gccaaaaatc atatcggtct ttttcaaccg ctgccggatc atatttcgtc 2291641 ggcattgttt gttcattcgt ttccatcata accctccagc atgtttaaaa atggctgaga 2291701 acgaaaaaag agctcttcat ccctgtaaaa ggacgaaaag ctctttcgcg gtaccacctt 2291761 ttttcatgaa ctcaatcagt tcatgcactt ataacggata acgggtgttt cccgaatttc 2291821 tctactcttc tttcaagaaa ttatgctccc gggcgacctt ccaatcagac aacataagaa 2291881 gcctttcagc aaacggcttc tctctctgca tgcgcctttt ttgtactctt cccgttctaa 2291941 gcaggtgtat ttatcagctc attgtataca ttatttatgt tctttattat agtaaaagtg 2292001 tttttgattc gtcaatcatc ttttccaaaa acaccgcttt ctatacagat gggcaggcac 2292061 ctattgccca agtttacata tgatgcttgt aaatgcgtag aggaggatgc accgtgaaga 2292121 aacgtttcag ctcttattcg ctgccgccat gggtaaggca aattcggctt gtatccgcac 2292181 aagtgattat tcccattacg atttttcaag gaatcagaac cattttcttt ccgacaacct 2292241 ttgatgtttt gctgctcgca atcctaatct ttttagcttg cgcccttcat ttagaatgga 2292301 tataaacaaa caagtccgcg ccattaagac gtggactcgt tttcagcctg aaattttttc 2292361 tcttgttcaa tctgatgaat tttcatcaca aacggctcta tgtttttcat ttgccaataa 2292421 gcctttaata attgtgtaca ttcctctttt tcatgctgtc ttttcccagt ttgataaccg 2292481 ttcagcacct tgtacatggc tgccggatat gccatatagc tgagaaaaag gctgacttcc 2292541 gcttcacgca aagggaatga tttcgtatat ccataaaacc attcgacgca ttccggacaa 2292601 gctttcggaa agcctctgaa catttttgta taaaagccga gcaggtcgtt ttgcggcgga 2292661 ccgacagatg ctctttcgaa gtttgtaaaa tatccggtcc cggcatcatt atacagaaaa 2292721 tggtgtatag acaggctgcc gtggttcatt acaacccttg aaacgtcctt ttcctttgcg 2292781 gactcatacc agtcctccag ccgttccagc gcaaagttca ccgcggaaat ggtttcagaa 2292841 aaataggtta tggcctggag ttcaaaggga gaaaggtacc attccttctc cgctctatcc 2292901 acaaactgct catagaaaat tttatcttgt tcccactttt ttttcgtttg cccgtaataa 2292961 cgttcaatct catcacgtct aacctttagt tcctgcgcgg ttctctcgtg aagacgggct 2293021 gtttctctaa ataaataagc atgtttttga tcccgttctt cctcttggtc aaattggagc 2293081 caaggcatta aatagtagat atctccgtat tgtatgcctg ctgagaaaaa ctcaccgcta 2293141 tttgttctgt aaacgggaac gaatgaacga aagccttttt cctcaatcgc caccatatga 2293201 tctgtaaaat gcttgccgcg accttctttc aattttttca gggcaaatat gccgtagtct 2293261 gtatacactt tccaaacaag aggactgaca ggctcaataa attgagcagt cagtccgtat 2293321 tcctgaagaa ccgattgggt atcttccatt tcattcacca cattttccga tcacttacgg 2293381 tttacgcatg gctattttta tattgaggaa tatagagaat ctgtcctgct tttaattcat 2293441 catccaaggc taaagaattc atcctgatca gctgctggga tgtaatttca taccgttcgc 2293501 ataaacgctc gatcgtatct tcctgctgca caatacaaat tttcattctc gaaaactcat 2293561 ccgcttcttt tgtaaagagt tttgttaaat aaagagaatt atcactttcc tttgtttgag 2293621 gttccttcgt ttcagcagca ggagcaaccc taggaacagc atccgtttcc ttcctttcag 2293681 tctcagaaga ttcaggcagc tggaaggatt gaaaaggtgt ttcttcctta ggctcttcag 2293741 ctgatggtgt ttttctcact tcaatttcga agctctcttc ctcttgttct tcctcctcca 2293801 gcagcttagg cgctgaataa aaagaatcct cctcttcttg ttcaggcagg aaggtacggt 2293861 atgccggttc aggcaattct tcttgagatg cctcctccga gcttgttttt tgattgaaat 2293921 ggaaatgtaa atcggcattg tcattctcca tatatacagc tgaagctgtt tctctgctat 2293981 cttctatgga gagagcggcc tctgatacac tctccaaagc ttcatccggt tccgcctctt 2294041 cttggcaaag cgcaggatca gcctgatccg attgagctgc ttcttcattt tgagcctctt 2294101 ggcgcagcgc atattcatga ttaggagaca ctgttgtttc ctctttttcc tttgcaatca 2294161 cagtctctga atgaagctca gcttccaaag caggcgattc ttctgctcca acgtgttcac 2294221 gaagctcagt ctccgctgga gagtctgctt cttcacgaac atccgctatt gcagctgccg 2294281 gctctgccgt ttcttttttt gctttaacga tctcttgaat ctctatttct gaaggatcag 2294341 gttctggctc agattcttct gtttccgatt cagcacgaac ctccgtttcc ggcacagcaa 2294401 gctcttctga ctcttcttcc tctttcacat cttctctggc ctctggttct gaagcaaccg 2294461 attcaggcgg ctcagattct gctttttctg tctccagttc ttcacggagc cccgctttcg 2294521 agataaaaag ttctggcggt tcggctggcg gttcatgctg aagaactgct tcctctgccg 2294581 atgatgcacc cggttcttct actacactat gtgccggcgg ctctgaaagc tcttcctccc 2294641 tgaatgccgc aggagcttca tataaaggta tctccggctc tttgtcttgc gtatcgtcca 2294701 aaagcccttc gatcgctaaa tcagcttgaa ttgttaaaat gcgcgaatcc gtcaattgat 2294761 agtcaaatgc gtcaataaag acgaagacat cctgtaaatg gctcacttta tttttcggaa 2294821 tggtaatatc cacaggaaaa cagtgagtca gttccgcact tccatcctct ctctttctga 2294881 cttgttcaac aaaccgctta tctgtataaa tctcttcggt atgtttgttt tgatctatgt 2294941 tgtactcacc tgtaagttca agcgatccta tgattgatac ataatcattt acttcctgaa 2295001 ccctaatatc aggatctaat gaaatagaaa gcagttcaga aacttcctgt cctttttgga 2295061 aacagatcga ttcttctaca gaaaattgca atcgatgatt ttgcggcaag ttcatatcct 2295121 cctttcatct aatccttaaa attagatgtc actaaaggtg tatgtatgaa ctggagaaaa 2295181 tatgagtggg agagcacgaa aaaaccggca caaggagtcc ttgataccgg ttttcactct 2295241 tatctgcggc tgatctcagc aaatactttc tcagctgcct ggattgtgtt ttcaatatct 2295301 tcatcagtat gggccgttga gaggaaaaga ccttcgaatt gtgatggcgg aaggaatacc 2295361 ccttcatttg ccatcccttt ataatagctt gcgaacagct tcaaatcaga tgatttcgct 2295421 gtttcataat tgatgactgg ttcgtttgta aagaagaaac cgatcatcga acctgcacgg 2295481 ttaaaggtat gcggaatgcc atgagccccg gcggtttttg aaattccttc ttccagtctg 2295541 tcgccttttt tgatgaaatt cttgtaggat tcaggtgtca gctgtttcaa tgtctctaag 2295601 ccagccgtca tcgcaagcgg gttgcctgac aatgtaccag cttgatagat cggaccgctt 2295661 ggagcgatct gctccatgat ttctgccttt ccgccataag cgccgacagg aagtccgccc 2295721 ccgattactt ttcctaaaca agtcagatca ggcgttacgc cgaagtagcc ttgagcgcag 2295781 ttataatcga cccggaagcc agtcatcact tcatcaaaaa tcagcaggga gccgtactgc 2295841 tcagtgatat cacgcagacc ctgaaggaaa ccttcttgcg gcggaacaac acccatattt 2295901 ccggcaactg gctctacaat gactcccgca atgtcttcac cgaattgctg gaaagcaagc 2295961 tttacacttt ctaaatcatt gtacggaacg gtgatggtgt ttttcgcaat gccttcaggc 2296021 acccccgggc tgtcaggcag accgagagtg gcaacacctg aaccagcttt aatcaagaga 2296081 gaatcgccgt gtccgtggta gcagccctca aattttaaaa tcttgttgcg gcccgtatag 2296141 ccccttgcca aacggagggc actcattgta gcctctgttc cggagcttac cattcgtaca 2296201 atttctacag atggcacacg atcaatgacg agcttagcca gttcattttc tacttcagtc 2296261 ggagcaccaa agcttgtccc gtattcagcc acttttttga ggctttctac gacgcggtca 2296321 tttgtatgcc ctaaaattaa aggcccccat gacaagacgt agtcaatata ttcattcccg 2296381 tcaatatcaa agattttcga gccttttccg cgctccataa aaatcgggtc catgtctacc 2296441 gatttaaatg cgcgaacggg actgttcaca ccgcccggca tgagtttttg cgcttcttta 2296501 aaagccgttt ttgatttttc atagcttctc atctgcctca actcctgtca actgaataaa 2296561 attactccgc aagccatttc gctgcgtctt tcgcatgata cgtaataatc aggtcggcac 2296621 ccgcgcgctt catgcttgtc aaaatttcca acacaatttc tttttctttg atccagccgt 2296681 tctgcgctgc agccttcacc attgaatact ctccgcttac attataagcg acgagcggca 2296741 aagtaaactc attttttacg tcacgcatga tatccatata agaaagcgaa ggtttgacaa 2296801 tcaaaaagtc cgcgccttcc tcaacatctg attgtgcttc gcggagtgcc tccatacggt 2296861 tggcagggtc catctgatat gttttgcggt ctccgaattg cggtgtgctg tttgctgcat 2296921 cacggaacgg accgtaaaac tcacttgaat atttaacagc gtaagacatg atgggaatat 2296981 tgacgaatcc ttctttatca agtgcttctc tgatcactgt aacaaatccg tccatcatgt 2297041 ttgatggcgc aatgatatcc gcacctgctt tcgcttggct gacagctgtc tgcgccaaaa 2297101 gctccagcga ttcatcattg agaatgactc cgtctttgac aagtccgcaa tggccgtggt 2297161 ctgtatattc gcacaggcac gtgtcagcga caacaaccat ttcagggaag tgttctttaa 2297221 tttctgtgat ggctttttgg acaattccgt gatcatggta cgcttgtgtt ccgcaatcat 2297281 ctttttcttc cgggatgccg aacacgataa cagattgaat gcccagtttg accagctccg 2297341 ctacttcatc cttcaataaa tctaatgata catggtgaac atcaggcatt gacggaacag 2297401 cttttttgcc ttccagccct tcaacgacaa aaatcggata tataaaatct gatggatgca 2297461 aacgtgtttc ctttaccatt tctctcattg cttttgatgt ccgcaggcgg cggtgtctat 2297521 taaatgattg actcatattc tctcttcctc tcttgacatg ctgcacatta actcaagcat 2297581 gccatctatt gtaaatgtat caggcgtatg cgatgtgatg ccgtacgtca gaagggcatc 2297641 atttgttaaa ggcccaatgc tgatacaggc cgtcccattc gccttccact tttttaattc 2297701 ttctcccaag acatgcataa acgtatgtac ggttgatgaa ctcgtaaatg ttacatagtc 2297761 aaaggaatat tgacccgcag cgtctttcaa tgcctcaatg ccttcttcat ccggaatcgt 2297821 ttcgtagaga acccattcct ttacttcaaa accgagcggg acaagctctt gttttatcac 2297881 atcacgtgac aaattccctt tcatcacggt aatggtctcc cccggttcag catgctgctt 2297941 aagagcgtca gccaattgtt cagcaatata ctcctgtggc atcacatcaa ccgatacgtt 2298001 atgcattttt aaacggcgcg cggttttttc accgacggct gcaatttttt tatgcgcagg 2298061 gagaataagc tgattttcct tcagataaga aaaaaagaag tctgccccgt tcacacttgt 2298121 aaaaacaagc cagcctggcg cggcaagatc ctctcttacc tgttccgcaa catcattcgg 2298181 caaagcgcgg cgaaacgtaa tcaaagaggt taaaaccgct ttaccgccaa gcgcctccac 2298241 tttttgctga aatgatgctg cctgtgcctt attccgggtg acaagcactg tttttccttt 2298301 caacggaaaa tcattttcca tcctcgtcaa gctcccgttt tacacgatca attaaatctt 2298361 ttgctccttt gtcagccata agagcggcac agcgctttcc tacttcctcc ggatcgtttc 2298421 cggtgacggt ttctttaaaa atgattttgc cgtcaggtga agcgacaaga cctgtcattt 2298481 caatttcatc ctgtccattt aacacggagt agcccgcgat cggaacctgg cagccgccct 2298541 ccatcgcgtt taaaaaagca cgttccgcta agacagtccg ttttgtatat tcatctgtaa 2298601 actgagaaaa caacgccaac agctcttcat ccgattctcg gcactcaatc gccagggctc 2298661 cctgccccac agcaggcaaa cagcgctcag gctcaaggaa ttcggttacg acatcttgct 2298721 tccaacccat tctggaaagg ccggcagccg ctaaaataat tgcgtcataa tcctctgttt 2298781 ccagcttttg aagtcttgta tctatattac ctctaatcca tttaattgta aggtcagggc 2298841 gctcaatcaa aagctgcgcg cttcttctta aactgcttgt gccaatgaca gcacctttct 2298901 tcatttctga aagctttacg cgattctttg aaataagggc atcacgcggg tcctcccgtt 2298961 caggaataca gccgatcaca aggccttcag gcaaaacagc aggcatgtcc ttcatgctgt 2299021 gcactgccat atcaatctct tcgtttaaaa gcgcctgttc aatttctttg acaaaaagcc 2299081 cttttccacc cacttttgag agtgtaacat cgacaatccg gtcgcccttt gtcacgatct 2299141 ctttaatttc aaaagcaaac gaaggattga tttccttcag tttttgaata acccattttg 2299201 tttgagtcat agcgagtttg ctccgtctgg aacctacttt aatcgttctc atcatttctt 2299261 tcctcccgaa tctgcttggg acatcgttta actgaaccaa tggaattgcg acaggcttcc 2299321 aagcaggaaa taattgatca tcagcaccag aaaacaagcc gtattccaca gtgcagcgac 2299381 ctttccttgc agctccttaa tcagcctgat ataaagataa tagctgtaca gcagcaggac 2299441 gacaaacgaa ccaagcactt tggcgtcaaa ccaatacagc gtttctagtg agacatacgc 2299501 ccaaatgacg ccgagaatca aactcagcag cagcatcgga accccaatga catttaaaac 2299561 atacgccata taatcaagct tagataaatc ttctattctc aacagccatt ttccccactt 2299621 tttctttttc agcagatgat attgaaacat atatagcaca gaaaaaacga aagaaaggga 2299681 aaaagcgccg tatgaaagaa tcgccattgt aatatgaatc accaaaagct cggatacaag 2299741 ctgcccggaa aaagcagctg actgctgctc tgtcggtgaa aatgtgtgaa tggcgatcat 2299801 agaaaatcct ataacatttg taaaaaacac gataaagtca acacgtaaaa gctttgtcag 2299861 tacaagtgac agcgtgacaa gcacccaggc ataaaaataa agtgcctctg tcacatttaa 2299921 taccggaaac cgccccgtca cccacataaa ataggccaaa tacacggttt gcagagtcca 2299981 gacaatagaa agcaaccaga aggccatttt tccagccttc cggttgtgtt gaagaaaatc 2300041 tataaaataa aagagtacac ttaacgcgta aatgacgatt gtcccctcat taagtcttgc 2300101 cattgcagta tcaatcattc agctttcact cacttacaag tgggctaaag cccgcttttg 2300161 attcagcctt cttaaaagag tggaccttct ggctgctttc aacggttttc atcatttgac 2300221 ggcccgcagc ttcttcaata tcaaaaatct gcataaacaa cgcgagcttt tcttcagaat 2300281 cagcatctgc cgcaagctct ttcaccttta aaatcggatc acgaagcatt tggttaataa 2300341 tacttttggt gtgtttgttc aacagttttt tctctcttgt gcttaagtga ggcagcttac 2300401 gctcaatgct gtccatcgtt tctgactgga tggcaagcgc cttttcgcgc aatgcagaaa 2300461 taacaggcac aacaccaagt gtattcatcc attgtttaaa ttccacaatg gtttcttcaa 2300521 ttaacagttc aactttttca gctgtttctc tccgctcttt catgttcgct tctacaatgc 2300581 cttccagatc gtcgatatca taaagaaaaa caccttcaag atcattcagc gccggatcaa 2300641 gatctctagg cacggcaatg tcgaccataa acagcggacg tcccttgcga agcttattcg 2300701 cgttttccat catctctttg gacacgacaa attcacttgc accggttgaa ctgattaaaa 2300761 tatcagcctc cgcaagcgcg ctttcaagct gattcaagct tctcgcttca cctgaaaaac 2300821 ggtctgcaag ctccttcgct ttcaagtatg ttcggttaat gacagtgacc ttgccgattc 2300881 cctgtccgtg caggttttcc gcagcaagct cgcccatttt tcccgcaccg agaatcaata 2300941 tgtgcttgct tgaaagattt ccgaagattt ttttggcaag ttcaactgca gcatagctta 2301001 ctgacaccgc atttgagcca atgtctgttt cggcgtgagt ccgtttgccc actgtaactg 2301061 cctgcttaaa cagctcatta aaaatagtcc cgatcgtttt ttcttgctga gctgttttaa 2301121 agctgtcgcg tacctgtccg agaatctgcg tttcgccaat caccatagaa tcaagtccgc 2301181 aggctacacg gaataaatgc tcaacagcgg catcgctctc ataaaacgtt aagaacggtg 2301241 acagctcttc tttgcttaat tgaaaccaat cagctaaaaa cttttttata taataacggc 2301301 cggtatgaag ctggtcgact accgcataaa tttcagtgcg gttgcaggtt gagacaatga 2301361 tgttttcaag aatgcttttc tcttctttca gctgcaccat tgcttctgcc agctcattcg 2301421 gctgaaaact tactttttca cgtatctcaa taggggcgga tttataatct actcccacaa 2301481 caagtatatg catcgctcta attacacccc caacacccaa tcttaattta taatcattct 2301541 aacatagaac tcattattta taataattat aacatagttt ctttcacaaa atgtgaacag 2301601 attttaaaat tcttatgcta tattagaaaa agcttcaggg aaaagaagca ttcctattga 2301661 caataccaaa aacagcagaa atttactaca catcagctct aaaaaacaag aaggtgatat 2301721 gcatgaaaca aaaatcaatt ttattccctt gtctgctgct tgccgcttct gtatatgcat 2301781 ggctagaaag cggccaagcc gaactgtttt cagggcagga tcaatggcct gttctcctca 2301841 tgctgttagg cgcagccttt gtatatcaag gaaaaaaaga agccgtcaca ccccattttt 2301901 ttatcggttt gcttctcttc gggatcggtt tacacttttt tgccaagccg aaatgggtat 2301961 ggtggccgga tgattttgaa atgctcctct ttatgatcgg cttctcactt ctcgtttcaa 2302021 ccgttcaaaa aaaagaatat gtatatgaag ctgtgtcgat gatttgtttt tccctgtttt 2302081 tgtacttttt caaacaaatt atggcatggc ttgagtctgc gcatattcca acagcgcttc 2302141 tgaaggagta ttggccgttt gtctttattg gaatcagttt attgttatta ttgataaaac 2302201 gaaaaaaatc tatacgataa ataaaaccgg tagaggatcc tctaccggtt tatcattttt 2302261 ttgatcgctc cccaagcttc gtcttttccc tttttcgttt ctgaagaaaa gaggatcagc 2302321 tcgtcttccg gatcaatatt taatgtttgt cggacaacct tcgcgtgttt gtcccattta 2302381 cctttcggga tcttatccgc ctttgtagcg ataacaataa caggaatgcc gtaatacttt 2302441 aaaaattcat acatctgtac atcatcatta gatggcgcat gccgcaaatc aacgatctgc 2302501 accacagctt ttaattcctc gcgtgtcgtg atataggttt caatcattct gccccatgct 2302561 tcacgctcag actttgacac tttggcaaaa ccgtagcccg gcacatccac aaaatgcagc 2302621 tcatcattga taatgtagaa attaagcgtt tgtgtttttc ccggctttga tgacgttctc 2302681 gcaagatttt tgcgattgat taatgaattg ataaaagacg attttcctac gttcgatctt 2302741 ccggccaatg cgatttccgg aagcccccct tcagggtact gttccggttt tactgcactg 2302801 atcacgattt ctgactttgt gactttcatt tcttctctcc tactaaggca tgttccaaaa 2302861 cctcgtctaa gtgggacgcc aatataaatg tcagcccctc cctgacgctt tccggaatat 2302921 cctctatatc tttttcatta tctttaggcg caataatggt cgttaatccc gctctatgtg 2302981 cgccaagcgc tttttccttt aagccgccga tcggcagcac gcgcccgcga agcgtgattt 2303041 ccccagtcat gccgacttca cgcgaaaccg cccgtcccgt taaagcagaa acaagcgctg 2303101 ttgccatcgt aataccggct gacggaccat cttttggcac cgcaccctct ggtacatgta 2303161 tatgaatatc atacttctca tgaaagtcag gttcaatgcc aagttcttct gttttggatc 2303221 gcacatagct gaatgcagcc tgagcagact ctctcataac atctccgagc tttcctgtca 2303281 ggattaattt cccttttccc ggtgaaagcg atacttcaat cgaaagcgta tctccgccaa 2303341 cggttgtata cgcaagccct gtcactacac caacttgatc ctctgtttca gcttgtccat 2303401 atctgaaaat gcgttttccg ataaaatctt gaaggttctt ctcagtaacc gtaattcgtt 2303461 ttcgctcttc agcaacaatg gcttttgcag ctttacggca aattgcggca agctggcgtt 2303521 caaggcttct tacacccgct tctctcgtat agtaacgaat aatatcaaga atcgcctgat 2303581 cacgcagctg aagattgctt ttcttcagcc cgtgttcttt gatttgcttt ggaagcaagt 2303641 gatcctttac aatttcaagt ttttctattt ctgtgtagcc tgcgatatta ataatttcca 2303701 ttctgtctct gagcgggccc gggattgtgg ccaaattgtt cgccgttgcg ataaacagca 2303761 ctttggataa atcaaaggtt tcttcaatat agtgatcact gaagctgctg ttttgctctg 2303821 gatcaagcac ttcaagcata gcggatgatg ggtctcctct aaaatcagat gacattttgt 2303881 caatttcgtc taataagaag accggattca gcttgcccgc ttttttcatc ccttgaataa 2303941 tacgtccagg cattgctccg acataggtcc gtctgtgtcc gcgtatctct gattcatccc 2304001 gaactcctcc gagtgagatt ctgacgaatt tgcgtcccaa gctttttgca attgatttgg 2304061 ctaaagacgt ttttccgaca cctggaggtc ctgccaaaca gagaatcggg cctttcaggg 2304121 attttgtcag cttctggaca gccaaatatt ctaaaatacg ttcttttact ttttcaagcc 2304181 cgtggtgctc ttcgtccaag agacgtcctg cttctttcaa atcaagctta tcatctgttt 2304241 catccgtcca cggaagagca accagccagt cgatatagtt gcggatcaca gagctttccg 2304301 cagaacttga cggaattttt tcatatctgt tcaattcttt aagcgctgtt tctttcacat 2304361 gatcaggcat gcctgcttct tcgatttttt ccgtcagcgt ctgaacttcg ccagttttgc 2304421 cttctttatc gccaagctct ttttggatcg ccttcatttg ttcacgcaag tagtattcct 2304481 tctgcgtacg ctccatcgaa cgtttgacgc gctggccgat ttttttctca atctccagca 2304541 cttctttttc attattaata aaatcaatga ccttgttcag cctgtctttg acatcagccg 2304601 tttctaaaat atcctgctta tcctttagtt taaggggcag atgagaagca acgatgtctg 2304661 ccattctccc cggctcttcg atatcagtaa ccgcagcgta cgtttcggcc gagatttttt 2304721 tagaaatttt tatgtactga tcaaagtggt ctagcaaagt ccgcatcaat gcttcgtctt 2304781 ctgtatcttt tgaatcatct tcatgaataa gttgaatgtc aaccgacgtg taatcctcgt 2304841 gttcattgta tttgacgata tgggcgcgct tgaggccctc caccaacaca cgaatcgtac 2304901 cgttcggaag cttcagcatt tgcttaattt ttgtataggt gccgacagtg aaaatctcgt 2304961 cttcaccagg ttcgtctatc gaaatatcct gctgagtggc taaaaatatc atatgatcat 2305021 gcatcattgc ctgttcaaga gcctgaaccg acttgtcacg tcctacatct aaatgcaaaa 2305081 ccatcgtcgg gtacactaat aaacctctta aagggaggag cgggatgctg cgttttaatt 2305141 cttctgccat gtgactgaca cctccgtgac tttagtatga accattataa tacaactttt 2305201 tcatccttgt acaataaacg gcatggttcc attttctata aaacagtctc ctcgtagtat 2305261 accctttctt tctgatatga aaaaggaaaa gatgtccttc atgaaaaaaa ccctattatc 2305321 aaaatagggt ttaaacggat tctttattga tttcgatatg aaacggtttt tgttccgttg 2305381 gcggattcac caaaatttca tcaagcactt cttggaacgt cttcactgca ataatctcga 2305441 tcccgtcaat ctgctttaag atggcctgct gattttcata tgggataatc acctttttcg 2305501 caccggactg cttggccgct tttattttcg gaatgacgcc tccgatgggt ttcacaagac 2305561 cgttcaggct gatttcgccc gtcatcgcaa cggtattgtc aataggaatt ttgtgtatcg 2305621 ccgagaaaat ccccgccgcc atcgcaatgc ctgctgacgg cccatcaatc ggaatccctc 2305681 ctgggaaatt gatgtgaata tcataatcag aaggcttcat tcccattgtc cggagcacgg 2305741 ttaatacatt ttcaaccgaa cccttcgcca tgctttttcg cctgatcgat tttgattggc 2305801 tgccgatgct ttcttcttca gctattcctg tgatgttaat tgatccttta tcttgagccg 2305861 cggttacact tacttcgatt tccagaagcg atccgctgtt aggcccatag actgcaagcc 2305921 catttacaat gccaacctgt ggttcaacac cgattttttg ctcgtgcttt ggagtaagct 2305981 gactggagtg aatgacccat tcaatatcct caatcgtaat gtcctttcga ttctccgtta 2306041 cagccatccc cgctgcgatt tgaatcatat tgacggcttc ccgcccgttc cgcgtgtagc 2306101 tggtcaaaag atccagtcct tcttcggaga tatttttttc aattttatcc gctgctgttt 2306161 tggcaaccgt tttcagctcg tccttttcaa gctcgcggaa aaaaacctcc aaacagcggg 2306221 accggatagc tggcggaatt tcgtttggca ttctcgtggt cgcgccaatc aagcgaaaat 2306281 cagccggcag cccattttga aaaatatcat gaatatgatt cggaatttgt gtattttcct 2306341 cactgtaata cgcactgtct aaaaagactt ttctgtcctc aagcaccttc agcattttat 2306401 tcatttgaat aggatgcagc tcccctattt catcaataaa cagcacaccg ccatgggcat 2306461 gggtgacagc tccctgcttc ggctgcggaa tcccagcctg tcccatcgct ccggcccctt 2306521 ggtatatcgg gtcatggaca gagccgatga gcggatcggc aattcctctt tcatcaaaac 2306581 gggctgttgt cgcatcgagt tccacaaaga cagcctgctc tttaaacggt gattgtttat 2306641 gtttttttgc ttcttccaac acaagccgcg cagcagccgt tttcccaact cccggtggcc 2306701 catagacaat cacatgctga ggatttggcc cgcataaagc cgcctttaat gctttaatgc 2306761 cgtcttcctg tccgacgata tctttaaagc ttttggggcg gaccttctca gataatggct 2306821 cggacaagct gatagcgcgc attttccgaa gctgctccat ttccttcttt gattctttat 2306881 ctatcgtgac cttttgtgtc ctttgatttt taagcaaatt ccaaaaatac aaaccgatga 2306941 tgatcccaaa aaacagctga ataaataacg cgatccctgt ccaactcatg gtggtccctc 2307001 ctgaaaaaca atttatgtat ccaattcatt cctctgattg ctagtatctc ccatagaaga 2307061 cgggaataaa cgtttttccg gaagagttgc atgcaaaaaa acctcctgag tgttaccact 2307121 caggaggttt gtgcttatct ttatgcagat gttttatctt ggcttacctc agtgccgtct 2307181 tttaataaga ggcgaggagg ctctccgtgt gtcacagttg ccccggtgat tacacatttt 2307241 tcaatgtcat cacgagaagg cagctcaaac atcacatcaa gcatgatgcc ttcaatgata 2307301 gaacggagtc cgcgtgctcc agtcttgcgt tcaattgctt ttttagcaat ttcagaaagc 2307361 gcttcttctt caaactcaag ctcaacgttg tcaagctcaa gcattttctt gaattgctta 2307421 acaagagcgt ttttcggttt tgttaagatc gcaaccaatg cttcttcgtc aagcttttca 2307481 aggcttgcaa taaccggaag acgtccgata aattcaggaa ttaacccgaa acggagcaaa 2307541 tcttctggaa gcacttttga aagaagatct tctttctcaa gatcagcagc tttattgtcg 2307601 gcaccgaatc caatcacttt ttggcctaaa cggcgtttga tgatttgttc gataccatcg 2307661 aaagctccgc cgcaaatgaa caaaatattt gttgtgtcaa tttgaatgaa ttcttgatga 2307721 ggatgcttac gtccaccttg aggcggtacg cttgccactg taccctcaag aattttaagc 2307781 aatgcctgct gtacaccctc acctgacaca tcacgtgtga tagacgggtt ttcagatttt 2307841 ctagccactt tatcgatttc atcaatatag ataatgcctt tttcggcttt ttccacatca 2307901 taatcagcag cttggatgag cttcaagaga atattctcta catcttcacc cacgtatcca 2307961 gcttcagtca aagatgtagc gtccgcaatc gcaaacggca catttaaaat gcgagccaat 2308021 gtttgcgcca gaagggtttt accgcttccc gtagggccga ttaatgaaat attacttttt 2308081 gaaagctcaa catcatcaac tttgctgttg gagttaatgc gcttatagtg gttatacaca 2308141 gcaacagcaa gtgatttctt cgcttgatct tggccgatga catattcatt caaaatttcg 2308201 cgaatttcct gaggctttgg tacgtcttta aattctactt cttcttctgt tccgagttct 2308261 tcctctacaa tttcagtgca gagttcgata cattcgtcac atatatatac accaggtcca 2308321 gctacaagct tacgaacctg atcttgtgtt tttccacaga acgagcattt taattgtcct 2308381 ttttcctcgt taaatttaaa cattctttca ccccttaatc ttgtctcact ttttctttta 2308441 ccggcagagc aaaagaaaat gattcttgaa acgaacgagt atgtattgca ttttaccata 2308501 ctttccaaaa agacggtaac aatgtgtttc tgacttgcac attctatatg tatgacaaaa 2308561 aacagccctg cattaactat attgccccaa gaaaaagaga taactcataa ttgtacaaaa 2308621 caaggcacga atgattcgcg ccctgtttta ttagtactat tattatgcac catattaacg 2308681 gttttctaca agaaaatcaa ttgctttgcg aacttttaaa tcttctttca tcgcgtcagt 2308741 agaaccgatg gcttgtttaa tattttcaac aggcatgttg tatgcttcag ccatttttgt 2308801 aagctcagca tcaacttcct catctgatac ttcaaggttt tccgctttcg caatcgcctc 2308861 aagagtcagg ttagatttta cgcgtttttc agcatcttct ttcatttgct ctttaagcgc 2308921 agcttcatct tggcctgaga attgagtgta aagctcaagg ttcatgcctt gcatttgcag 2308981 acgctgttcg aattctttca gcatgcggtc aagctcagtg tcgaccattg cttgaggcac 2309041 atcgatttca gcattttcag aagctttcag aacaagctct tcacgcaatt tagcgtcagc 2309101 ttcgttttct tttgcttctt ctaaacgttt ctttgttttt tcagttaatt cagcaagtgt 2309161 ttccacttct tcatcgatat cttttgcgaa ttcatcgtca agctcaggaa gctctttcgc 2309221 tttgatttcg tgaattttca ctttaaacac agctggtttg cctgcaagat cttcagcgtg 2309281 gtactcctca gggaatgtca cttcaacatc cttctcagca cctgcttcaa ggccaactaa 2309341 ttgatcttcg aagccaggga tgaatgaacc agaacctact tctagagagt agttttcagc 2309401 ttttccgcct tcgaaagctt cgccgtcaac gaatccttcg aaatcaagaa caactgtgtt 2309461 tccttcttca acggcgcctt cttcttttac aacaagctca gcttgacgct cttgaagggc 2309521 ttttagttcg ttttgaacat cttcgtcagt tacagttgtg tcgtcttttt caatgcccag 2309581 gcctttgtat tcgccaagct tcacttcagg ttttactgtt actttcgcag tgaagattaa 2309641 gctttcgcct ttttcgattt tttcaacatc gatttcagga cggtctacag gctcgattcc 2309701 agcttcttca accgctttag ggtattctac aggaagaaga atatccaaag catcttggta 2309761 aagagcttct acgccaaagc gctgttcgaa taatccgcga ggaattttac ctttacggaa 2309821 tccaggaatt gaaacttgtt ttactacttt tttaaatgca tcatcaagtg ctgttttaaa 2309881 cgtttcagca tcaacttcaa ccgttaaaac gccttcgttg ccttcttgtt tttcccattt 2309941 tacagacatg tgtttccctc caaaaatcta ttcaggttgt gtcggtcttc cattctaaag 2310001 caatcattcg gcttcgtcca acaaaaacaa agctgccaaa gatcagaatc attatgtata 2310061 gatgttaata atgaactgca aagcctgtcc aaccgtattt cttataaccc gttatacaca 2310121 aatacaacca ctatattata acataacaca tagcgctttc aactatatgg cgcgatttac 2310181 aaataagaaa tttcttcaat atcttttaac attgtgcaag cttcatcgag ttctctgtct 2310241 gtaaattcat acatcatatg aagttcttcg ctttcaattt caatcccgtg catctcgtaa 2310301 ccgactttat gaagggcagc cgcccaaagg tcagccgaca gcaatttcgg ctggaacgga 2310361 tataaaacgt acaaatgtct tctccacaat tcttctactg ctgcatataa ggttggattt 2310421 tcatttccaa gtgtctcatc tagcaccctg agaacacggt gaagaatcgg cgcggcatca 2310481 ggcggaacaa tctctgacgg ttcaattgtc aacgactcgc caaatttact aatgtgtaca 2310541 ggtttactgt actcatgctc agccaacagc atgacaatca tcgttttgat aatcggatgg 2310601 gctgaggggt cttggaggat tgttttgagc aatcctgtat actttgctac gttacggtct 2310661 tttaaggaat gaatgagatt catttgctcc tcagggcttg ccagcacttt ctcggtgtca 2310721 attgtatcct catattcttc ggcccaagcc tcgtcctcac gatccggatc ggtcattttc 2310781 cggctgaaat ccagcagctt ataaaattgc tcggcacttt ctgccggcag ctgattttct 2310841 tccaaaacgg cttcaatggt gcttttgact tcttcgtact ttttgagctg aattaagatg 2310901 gtcatgtaca cctgcaaaac cgtaaaataa tggccataac cttctttgag catcttctcg 2310961 cacacgcttt ctgcctcttc cagctcgccc agctctaaaa agcagatggc catccctaag 2311021 tgaagatcgg attcagtatc atcatatttc atcgcttctg aaaacagttc aagcgcttct 2311081 tgatactttt tttccttgag tgatgacatc cctttttcca caaggcggtc tttcagatga 2311141 ggaaaaggaa taatttttgc gtttttcttg tcatgcgtca tacctatatt cctttcaggc 2311201 atttattttg ttcaagtgta tcaacacctg tgaacaaaaa caagaaatga aaggtttcac 2311261 caggcaaaaa aagccgccgg acaaataccg gccgcttttt caggcttgaa gccaagagct 2311321 tctttgtgat tcaaattgct tgatttcatc ttccagcagc agcgttaatg aaatttcatc 2311381 atatccgttg atcagcatct ctttccaatg cggatcaact tcaaatgaaa tttgattgcc 2311441 ttcactgtca tgaatcagct gattttcaag gtcaacagtc atttgcaatg actggttttc 2311501 atactggccg acaagctgtt tccaattgtc atatggcatg cggatcggaa gcatgccgtt 2311561 tttaaagcag ttctgatgga aaatatcagc gaatgacggc gcaatgataa ttttaaaccc 2311621 ataatcatca agtgcccacg gagcgtgttc acgcgatgac ccgcagccga agttttctcc 2311681 tgctattaaa atggaagctc cttgataaac aggctggttt aattcaaatt cagggttcgg 2311741 ttcaccattc gcatcatatc tccagtcaaa gaatgcaaaa cgtccgtagc ctgttctttc 2311801 aatcctcttc aaaaattgct taggaataat ctggtctgta tccacattga tccgatttaa 2311861 tacggctgct ttccccgtat gtgatttcaa aggttccatc tcgcgcactc cttacacaac 2311921 tgttttttcc tgataaaact ttctgacatc aacgaagtgt ccgtgaatgg cagccatcgc 2311981 agccattgcc gggctgacga gatgtgttct tgcacctttt ccttgtctgc cctcgaagtt 2312041 gcggttagag gttgatgcac agcgctctcc ctcaggaaca acatcattat tcatactcaa 2312101 acacatgctg cagcctgact ctctccattc aaatccagct tccaagaaaa tctggtcaag 2312161 cccttctttt tcagcctgaa gcttcacgct ttgggatccg ggcacgacga tggcccttac 2312221 gctgtcagct accttcttcc ctttgatcat gtcagcagcc tgtcgaaggt cagtcatgcg 2312281 ggaatttgtg caggaaccga taaatacgtg ctccacttta atgtcttcaa ttttttggtg 2312341 aggagtcaat cccatatatt cataagcacg aatcgcttct tttttatcgt cttctgcaga 2312401 aaagctttcc ggcgcaggaa cttcagaatc gacaggaaga accattcccg ggttaatgcc 2312461 ccatgtcacc ataggggaaa ttttgttgcc gtcaaggacg atagatttat cgtaaacagc 2312521 gcccgggtct gtgcgcagcg ccttccattc ctctacggcc ttgtcaaatt cttcgccttt 2312581 tggcgtgtac ttgcgatttt tgcaatattc aaacgtcacc tcgtcaggtg caatcaaacc 2312641 tgctcttgct cctgcttcaa ttgacatgtt acaaacagtc attcgttcat ccatcgtcat 2312701 atttctgaat acttccccag tgtattcaat gacgtagcct gtgccgaatt tcacaccgta 2312761 tttgccgatg acagcaagga tgacatcctt tgccgttacc cctttttgaa gcgttccatc 2312821 tacgcgcact tcaagtgttt ttggacgctg ctgccaaagt gtctgtgtgg aaaggacatg 2312881 ttcaacttca ctcgtcccga ttccaaatgc aagagcgccg aaagcgccat gtgttgatgt 2312941 atgactgtca ccgcacacaa tcgttttccc tggaagcgtt aagcctagtt caggtccgac 2313001 gacatggaca atcccttgat ccacactgtg aagatcggca aggcgcacgc caaattcctc 2313061 acagtttctt tcaagcgccg ttacctggcg tttcgcaact tcatccttta tctcaaaacg 2313121 attgacagtc gggatgttgt ggtccattgt cgcaaatgtg ttttggggtc ttctgacctt 2313181 tcttcccttt tgtctcaagc cttcaaatgc ctgaggagac gtcacctcat gaatgaggtg 2313241 caaatcaata tagagaagat ccggctttcc ctcaccatgt tttacaatat gctgatccca 2313301 aatcttttcg atgattgttc gaggcatcat cttttatttc ctccctctac ctagagctaa 2313361 gaccgcttaa cgtaagctgt cacacattag aaattgtatt ttcactcatg attgctgcct 2313421 taacttcctc tgtaatggcc tgagtgctgc tgaactcttc actccgtgcc aagtctcttg 2313481 ttctttttcc agaagccaag actttgttta ccgcatcttc tacagctttc gcttcctctt 2313541 caagcccgaa agatgttctc aaaagcattg ccgctgacaa tatggctgcg aacggatttg 2313601 ccatcccttt accggcaata tcaggcgcgg agccatgaac aggttcaaac agatgaaggc 2313661 cagagcttga taggctggct gacgggagca ttccgagcga gcctgtaagc atggacgctt 2313721 catcgcttaa aatatcaccg aacatatttt cagtcaccac gacatcaaat tgattcggtg 2313781 cataaattag ctgcatggcc gcgttatcca caagcatgtg ctcaagcttc acatcaggaa 2313841 attcttgtgc aacgtcctca gccacttcac gccacagccg gcttgattca agaacattcg 2313901 ctttatctac agaggtcact ttgccttttc tggctgccgc cattttgaag ccctctctga 2313961 tcactcgttc aatttccgtt cgcttataaa acagtgtatc tactgcttcc tgctcacctt 2314021 cagtgtttac ataacgtttg ctcggctggc cgaaatacaa gccgcctgtg agctcacgaa 2314081 cgataacgaa atcaacatta tctatatatt cttttttcaa aggcgaagcg tcagaaaggc 2314141 tttcaaatac cttcacaggc cgcaaattcg caaacaaatc aagctgtttt ctgatgctga 2314201 gcagcccttt ttccggtctc agttccgaag gattttgatc ccatttcggt ccgccgacag 2314261 caccaagcaa tatcgcgtct gcatttttac aagcagcaac ggtttcctcc gggagggggt 2314321 tatgatgttc atcaatagcc gcccctccaa tcaggccata ttcaaattca aattcatggt 2314381 taaagcgttc ggcaacactt ttcagtacgt ctgtcgctga ttctaatact tcagggccga 2314441 tcccgtctcc gggcaataga gcaatacgtt tcttcaagtt aaccgttctc ctttctttta 2314501 tgatccgaca gctgtgtggt ttttcaatcc gctcatattc gactggaaaa ccaattgacg 2314561 gtttactgcg ttcaaatagg ctttcgctga tgcttctaat acgtcttgcg ctatgccccg 2314621 ccctgctgat tcttttccgt tcaccaaaac tcttacatac acctgggcaa atgcatcttc 2314681 gccttttcta ttagactgaa tgcggtagtc taagagctcc acatccttat cgatgcagcg 2314741 ctcaagcgta ttgtagattg cttccacgct tccagctcca gttgcagctt cctgaataag 2314801 ctgtgcgttt tcttgatttt tcaaagatag agtagccgta gggacctgac ttgttccgta 2314861 atgtacttgc agagaaagaa attcataccc aatcttgcga tctgttactt tttcttctaa 2314921 aataagagaa acaagatcct catcagtgat ttcttttttc ttctcagtca actctttgaa 2314981 catcgtaaag aatttattaa tctcttcact gtcaaattgg aatcctaaag cagtcagccg 2315041 gtctttaaat gcgtggcgtc cggaatgttt acctaggaca agcgcatctg cggttacgcc 2315101 gacaagctcc ggtgaaataa tttcataagt cgatttttcc tttaaaaagc cgtcctgatg 2315161 gatgcctgat tcatgagcaa atgcattatc tccaacaacc gctttgttgc gcgggacagc 2315221 catgcctgtc agtttgctta ctaaatcact tgttctctta atctcgttca gcgtaatacc 2315281 tgtttcgact tggtagaaat cttttctggt atggagggct acggcaattt cctctaatgc 2315341 cgcgtttccg gctctttcac cgatcccgtt cacagcgcat tcgatttgat cagcgccatt 2315401 ttcaatcgca gcaagagagt ttgcgactgc cattcccaaa tcatcatgac agtgggctga 2315461 aagctttgct ttgtgaatgt tcggaacgtt ttctttcata tatttaaaga tatttccgta 2315521 ttccgccggg gccaggtagc cgacagtgtc cggaagattg ataacactgg cgcctgcgtc 2315581 aatcactttc tcgacgattt ctgctagaaa cggcagttca gtgcggcagg catcttcagc 2315641 tgaccattgc acaatcggaa aacgttcttt tgcgtatttc accattccaa ctgctctttc 2315701 aatgacttgt tcacgtgtca ttttcagctt gtgcttcaaa tgaatgtccg atgtcgcgat 2315761 aaatacatga attcttggtt gagcgccatc ctttaacgct tcccaagcag catcaatatc 2315821 accttttaca caacgggcca gaccagttac tgaacaattt ttaatggttc ttgcgatttc 2315881 ctgaacagct aaaaagtcac ctcgggacga agcgggaaat cccgcttcaa tgatgtctgc 2315941 cccgagtctt tcgagctgct tagctatggc aagtttctcc tgtgtattca agttcactcc 2316001 aggggactgt tcaccatcac gaagcgtcgt atcgaaaaaa ttaattttgc gcaacggaga 2316061 ccaccgcttc cttcttcttg ccttgtttca caaacggcat catttcacga agctttcttc 2316121 ccactacttc gatttgatgt tcgttctcgc ttgcattgat agcgttgaaa cgaggacggt 2316181 ttacttggtt ttcgacgatc cactcttttg cgaatgtacc gttttggata tcttttaata 2316241 cttctttcat agattctttt actttggcgt ccacaacgcg agggcctgat acgaaatctc 2316301 cccactgtgc tgtgtcagag attgaatatc tcattcctgc aagtccttct tcgtacataa 2316361 ggtctacgat taatttcagc tcatgaagac actcgaagta tgcaagttca ggctgataac 2316421 ctgcttcagt taaggtttca aatccggctt tgacaagcgc gcttaatccg ccgcaaagaa 2316481 ctgcttgctc accgaacaaa tctgtttctg tttcttcttt aaatgtcgtt tctaatacgc 2316541 ccgctcttgc gccgccgatt cctttagcat aagcgagggc tttgtctctt gcttctccag 2316601 tcacatcttg atagattgcg aacaatgcag gtacgccagc tccttgctca tatgttcttc 2316661 ttaccaagtg tcccgggcct ttaggggcca ctaagaatac atctacatcc gccggaggaa 2316721 caatttgatg gaaatgcacg ttaaatccat gagcgaatac taatgatttt cctgctgtca 2316781 attcatcttt gatttcagct tcgtatactt tttgctgctg ctcatccgga agcagaacca 2316841 tgatgatttc ggcttgggct gccgcttctt ttactgaaaa tactttatgt ccgtcttctt 2316901 gggcttgagt gaaagatttt ccttgtctaa caccgacgat cacgtctact ccgctttctt 2316961 taaggttcag ggcatgtgcg tggccttgcg aaccgtaccc gataaccgct actgtttttc 2317021 cagccaatac gttctctttg atatcaccgt tataatatac ttttaccatt tcaatctctc 2317081 ccttgttatg ttttatacaa tagatattgt tttattggat gacgcctttt gctgggttcc 2317141 cctcgcaaaa gccgttgtac ctgttctcgc gatttcttta atgccataag gttttaataa 2317201 ctcaataagc gcttcaattt tgttagattc acctgtcacc tgaacaacga tgctgtctct 2317261 gctgacatca acgacagagg ctctaaacgg ttctatgatt ccattaatct ctgttcttgt 2317321 tgaaggtgcg gagacaacct tgattaaggc cagctccctc tggacaatcg attgatttgt 2317381 gatgtctgtg actttcagca catcaatctg tttgttgagc tgtttcgtta actgttcaac 2317441 atcattttca ccttcaacat gaacgacgaa ggtgattctg gaaacgccgg ctgtttctgt 2317501 gtgtccaact gtaatgcttt caatgttgta atgccttttt gtgaatagac cggtgatccg 2317561 gtttaacacc ccggagcggt tcaccacagt caatgtgata attcttttca aggtttcacc 2317621 cccaccattt catgcagccc tttccccgga gccaccatcg ggaatacttt ttcttcgctg 2317681 gcaacccgca cgtcaatgac aacaggttct cttgatgtta atgcctcttc cagcttttcc 2317741 tttgcttccg cttctgatga aattctgatg cctttaatgc cgtatgcttc ggacaatttg 2317801 acgaagtcag gctgagaagc gaatttagat tctgaataac gttcttcata gaaaatttcc 2317861 tgccactgtc tgaccattcc gagacaagcg ttatttaaaa tcactacctt gaccggaaga 2317921 tttaattcgc gaataacatc gagttcttga agcgtcattt ggaatccgcc gtctccgaca 2317981 accgcgacaa cagtagcatc tttttcggcc agctgtgcgc cgatcgccgc cggaagaccg 2318041 aatcccatcg ttccaagtcc gcctgacgtg acccatttat ctgctttttg gaacggataa 2318101 aattgcgctg accacatttg atgctggcct acatccgttg cgacaatggc ctctcctttt 2318161 gtaaattgat gaatatattc aatcaatttc tgaggtttaa aaccttcttc ttcattatct 2318221 acataccaga gcggatactc ttctttccat tctgcgagct gttttttcca ttcgcttgaa 2318281 tcgctttgtt tgccgtcttg tttgatcagc tcctgcagga caattttgct gtctccgact 2318341 acaggaatct gtgttttcat gatttttccg atttcagctg gatcaatatc gatgtgggct 2318401 atctttgcgt ttctggcaaa gtgtttcagg tttcctgtga cacggtcatc aaaacgggcg 2318461 ccgatactga ttaatagatc acattcatga agggccatat tggctgtata agtaccgtgc 2318521 attcccgcca tccctaggaa aagcggatgg tcagccggga agcctccgag ccccaaaagg 2318581 gtgtgtgcca cagggatttg ctgctgttca gcataatttt ttaattcttc tgacgctttt 2318641 ccgtgcagta cgcccgcacc cgccaggatc accggttttt tcgcactgct cacggcttcc 2318701 acaagcttgc ggatctgcaa ataattcggc tctgttgtcg gctggtatcc cgggagattc 2318761 atctcatgat cgtagctgaa ttctccttca attgttgcta catctttcgg aatatcaatc 2318821 aatacaggtc cgggtcttcc agttgttgca atatggaacg cttctttaat gatgcgcggc 2318881 agatcttccg gctggcgaac ctggtagctg tgttttgtta ctggcatcgt aatccctaaa 2318941 atgtctgctt cctgaaatgc atcgctcccg attacagagg ttgctacctg ccctgtaaag 2319001 acgactaacg gcaatgaatc aatcatggca tcagcaaggc ctgtaacaag gtttgtcgct 2319061 cccggccctg acgtggcaat gacgacaccc ggttttccgg agacccttgc gtatccctcc 2319121 gctgcatgaa ttgctccttg ttcgtgacgg ggaaggatat gtaccaaccc tgaattgtat 2319181 agcttatcgt aaatcggaag cacagccccg cccggataac cgaagatcat ttctactttc 2319241 tcttttttta atgattcaat cagcattaat gctccgctca tcgtctgtgt acattcggca 2319301 gatgctgaat ccacctgtac attagtcccc attttagttc ctccttttgg attttcatcc 2319361 tttaaagatc atcttttcat tagctagata gctgattatt caataaaaaa agcccttccg 2319421 cccacaatca gccgcgcagt aactgcgata gctaaaaggg gcgaaaaggc ttttctttcc 2319481 gcggtaccac ccttgtttac ggcctgttaa tcggccgtct catggatatt tctatccgct 2319541 ttagtaacga gtgaatcaag ttcacccggc caagtcctac tgtcatttca gactggcact 2319601 ctgaggcgag ttcaccttgt aaagcttcgc cggttctcag ctaacccggt tctctgtgga 2319661 aaactttatc aaggctactt atcctcatct gcgcttttca tattcagcct tcggaacggc 2319721 tttccagctg ttcaagaagg tcgtttgttt ttcatttttt tagaatcata ctgcgatgat 2319781 tttcgcttgt gaagcttgca tttatctttt gttgaactca tattacgccg ctttggacgc 2319841 agtgtcaaca gcatttttta aaattattag acaattttga ttaatcaatc tatattgtat 2319901 acgctttcat tattggtaca aaaggaattg caaatgttaa aagtttttat aattttttta 2319961 ttaatctatc aagaatacac cagaattatt taattttata taaacatgga agattttata 2320021 acacgatatg gttcgtatat ggattgagtc tgacagatca tcttgcaatc catttcaatt 2320081 tcggataggc acttctcttg ttccctcggc atacattaat gatatcttgc aaagaaaagg 2320141 tgatacgatg aataaatcat ttgcagacat gcaaggattt cctgcgggct ttccaagctt 2320201 ccccaacttt ccgcagcagt actatcctgc tgtccctccc ttttaccagc aaagccagca 2320261 gccatttgga ggctacggat acggacagcc gttcagtcag gcatacagcc cgttaaccac 2320321 tccctctgga atgtactcct cattcccata cgcttcagga ttttacggac agcaattttc 2320381 aggtgcaggc tttagcggcc atggcggcag cttaagtgct ccagcgatac atgccggcgg 2320441 attcagcggg gcgccaggcg tacacggagg ctttagatat taaagaatac cacaagggcc 2320501 gaacatctat tgcggtcctt ttattgtttt aaaacgactt cacaagtaca gtcacatttt 2320561 ctgtctttat atttggaaac aggatggaat atgattaaga tgaattgaac gatattctgc 2320621 acaatccgta agttttcgag gaggaataaa attgcatata aaaatagacg atttaactgg 2320681 acgtcaggtg gtttcactgg tgaatgagca tttacatagc atgacgctta tgtccccgcc 2320741 agaaagcatt catgccttag gtctagaaaa actaagaggg cctgaaataa cattttggag 2320801 cgcatgggaa ggtgatgaac tagctggctg cggagcgcta aaagaactgg acacccggca 2320861 tggagaaatc aaatcaatgc gaacatctgc atcacattta agaaaaggcg ttgccaaaca 2320921 agttctccag cacatcattg aagaagccga gaagcgaggc tatgagcggt taagcttaga 2320981 aacgggttca atggcttcat ttgagccggc aagaaaattg tatgaaagct tcggtttcca 2321041 gtattgtgaa ccgtttgcag actacggtga agatccaaac agtgtgttta tgacgaagaa 2321101 attgtgagac ggctttataa ggatagataa gtgcagggga aggtctgtct tatctatctt 2321161 tttttatatt cacacatttt tcacctttat gatacacgcc aatgttttca attttgttta 2321221 attcaaagaa cagcgggaat tacaaacgac atgaacgata tcatgcaaat tcataaagga 2321281 ggagattgat atgaaaagca tagttggtgt atatgaaact ccgcaggaaa ccatcgcagc 2321341 gattgaaggc ttacttacaa aaggctatga ttctgatgac atttctgttg tgacaagccg 2321401 gcgagataca gattatttgg agtcacgtac aggaacagaa gtcaatcaag ctatcgatgc 2321461 acatcaggac gaatctgaat cttttttcga taaactgaaa gattatttca caatggatga 2321521 tactgctaca cacagcaaag cattatccga cttggatatt aaaactgatg aaatagacaa 2321581 gtatcaagaa gatttggatg acggaaaact tctggtagcc gtcgatacag atgcagatgt 2321641 aattgctcct attgataacg gcaatgccct ttcaggcggc ttttcaagca caaatgaatt 2321701 ggattataca acgaaagaag aaaaaacgat gccgctccgg gaagaacagc tgaaggtcga 2321761 taaggaagac gttcaaaccg gcgaagtaga aataggaaaa gaagtgaaaa cagaaaaaag 2321821 agatatggac attccggtga gacatgatga aatttatgtc gaacgccgtc cagtggatga 2321881 aaataaaacg gacgctgctc ccgtcaacga ttcggaagag atcagagttc caatcgttga 2321941 ggaaaagctg gaagtgacta aaaaaccggt tgtcactgat gaagtggttg tcggcaaacg 2322001 cactgttgaa gaaaatgaac atatttctga aactgtgaaa aaagaagaac ctcgtctgaa 2322061 taaagaagga aaagttgacg gcttggatga tgatccgtta aataacaaat gaaaatcata 2322121 gaccgacaac aaaaaacctc aaatcctaaa tggatttgag gtttttcttt tggtacgtcc 2322181 caggagagat tcgaactccc gaccgacggc ttagaaggcc gttgctctat ccagctgagc 2322241 tactgggaca cgttttgttt ttttgttttt cgctttaact atcagcgaca agatttatta 2322301 tatatgggat gcaataataa gtcaacggtt ttttagaatt tttttcatga ggaagaaaat 2322361 tttcttcctc atgacatttt catagtgtga ctcgattttg cagatcctca atttcattgc 2322421 ctgcttggtc gtaaaaacgg actgtcgcag catcattttc taatgtcagt atagcatagc 2322481 tttctgtcct gcgcaccctc ggaagccgga tgctgcctgg gttaatcatc agttttccgc 2322541 gcagcacttc gcttcccgcg atgtgcgaat gcccgaagca gataacatcc gccccgagct 2322601 cctctgcacg atagtatacg tttaacaagg tctgttttat accgtgaagg tggccgtgtg 2322661 tgactagtat ttttcttgag ccggcagtca gaagaagctc gtccttaaaa tcgccggcaa 2322721 aatcgcaatt gccttttaca accgcataag gctccaatgc aggatgcctc gtctcaagct 2322781 cagagtcccc gcaatgaatc atgagatcaa cttctgcctc atgccgtttc gcaatggttt 2322841 ggagttcttc ttcaagccca tggctgtcac tgataatcag cacgttcatg tacaagcttc 2322901 ctccttatgc ctccaaaagc ttagacagct ttttaagcgc gtcagcccta tggctgattt 2322961 tatttttttc atcacttgtc agttcagcca tcgtcttatc tttatctttc acgataaaaa 2323021 ttgggtcata gccaaagcca tattctcctc tcggttcttc agcaatatac ccttcaacat 2323081 ggccttcgac tgtttttgtt tcctctccgg gaatactcac ggccagtgcg cagcggaaac 2323141 gggcggtgcg ctgttctttt tcgatacctt tcagctcgct gagcactttt tcgatatttg 2323201 cctggtcgtc tttctgttcc cctgcatagc gggctgaata aaccccgggt ctgccgccaa 2323261 gattatcgat ggatagtccg gagtcatccg caatcaccat tttgttcact gctttggcaa 2323321 cagcttccgc tttcataatg gcattttctt caaatgtatg gcctgtttct tcaatttcct 2323381 ctgtgaatcc aatttcagct aaagatttga catcatagcc tcttggctca agaatttctt 2323441 tgaattcctt cacttttccc ggattatgtg ttgcaataat tgcttctttc atgatgatca 2323501 agcctttctg tctttatttc agttctggca gagaatcacc cagcacttct ttttgcttgt 2323561 caatcagctc ttggattcct ttttccgcaa gacccagaag accgttcaga tcctctctag 2323621 aaaaagttgc ctcttccccg gttccctgca attccacaaa acggccgctg cctgtcatga 2323681 tgacattcat gtcaacttca gcagaggaat cttcttcata atttaaatct aacaaaattc 2323741 cctgttcctt atcaattcca acagagattg cagcaagaaa atcagtgatc ggatttgtct 2323801 tgattgttcc tgctttgatc agcttgccaa tcgcaatcgc catagcaaga aatgcgcctg 2323861 taatggaagc tgttctagtt cctccatcag cttgaatgac atcacagtca atccaaatcg 2323921 tccgttcacc gagcttttcc agatctacaa cagctcgaag cgcgcggccg atcaggcgtt 2323981 ggatctccat tgttctgccg gaaattttcc ccttagaaga ttctctgatt gttctttggt 2324041 ttgttgcccg cggcagcatg ctgtactctg ctgtaatcca gcctttccct ccgccccgca 2324101 aaaacggcgg tacgcggtcc tcaacagacg cgttgcagat tacctttgta tttcccgctg 2324161 ttattagaac agaaccttcc ggatggctga taaaatccaa atcgaatgtg attggacgca 2324221 gctcatcgtg ttgtcttccg tcatgtctca tgttttacct ccgattgtat gtacataaac 2324281 catttttgtc ccggaattga ataaagaaag aggcagccgg aacgctaacc tctttcttcc 2324341 tagtatatca aaaatcccaa tttaaaaact acccgtattc acttgagatg gtctggagac 2324401 cggttctgtg agcttttcgc ctttttcatt taccagctct gattttccgt tcactttaac 2324461 agagacgctt tttacatccg gctgctccgt taacgtcagc acaatgctgt tcagcacttc 2324521 tgaagaaatc attttcgtct tctcatcggc gctgccgaat atagattgat tgaaatccaa 2324581 cgtcacgcgc ccgtctttga ttttcggttt gctgaccagc tttacatctt cactgaagtc 2324641 tgttaacagc ccgctcacct tgctcggccc tttagccaat tcattaatgg ctgctgtgat 2324701 gtcgtctttt tccgaattgt cgattcgttt ggtcaccggc acgtagtatt cactgtcttc 2324761 attttccgcc aaatagtaga ctgtcagcgg atgggtagca gtgagatcat ttacaccggc 2324821 tgtttccaaa ttaatgccgt ctttgcggct taaatcatct gagatcggcg tccctcctac 2324881 aggcatctcc ttcagttcat gcccgtttat tctcagcttc actttatcta tcgaactaaa 2324941 ttgcgtcagc gtccacgtca cagattgaac gattttctgt tcgtcttctt tcttataatt 2325001 tttgaactca ttagagaaat cagctatcgc cgttccatct tttttgatgt caacgttaac 2325061 ggtggtgtca gccggcaata cagctctgaa gccattcgga agaatttcag acacaggccc 2325121 gccctgtacg aggtattcaa gcgcctgctt agccgtgctc tcacttttag gaagaggcag 2325181 cgtttgcgca acaacatacc cgtttttatc aatgagataa agctccctca taacagtaga 2325241 tgaggcttga tccgcttttg cggtatcgct tttttcactt tctgtttttt tggctgctgt 2325301 tgtatttgaa ttggcacccg cttcatcgtt cacgaatgta acgtcttgag gcggatcaat 2325361 ttcctcggct gccttatcag attgaaacaa accgcatccg gataaaagca aggcagaggt 2325421 gagacaagtg gcaccaatga ctgcaggtcc ttttttcagc atacttttcc ctcctaagga 2325481 tgtttgtact attatgtata cgagcctctt taggaaatag accgaagaat tccggcaaaa 2325541 cagaaaaaaa cccgcaacat accgttgcgg ggaaaactat cttttaatcg gttcttgcag 2325601 tgagatacat tccacatgcc cgacttcatg gccaaaccaa tcgtctgcga tttttgcaaa 2325661 ctgatcacgc gcccctgttg tcaggaactg atgatccggg gcaatcggag actggttcag 2325721 cagcccttta taagagagaa ttgtgctgac ttcccgggct gtttcatcgc cggacgaaat 2325781 aatgtttacg tgctctccca tatatctttg aatggcttct tttaaaatag ggtaatgggt 2325841 gcagcctaaa atcagcgaat caattgatgt gtcttttaac ggatacagcg aggttttaac 2325901 aatctcgtct gctgttttgt cgagaaactt cccgctttcc acaaaaggca caagcagcgg 2325961 gcaggcaagg ttttcaacct tcaaatcagg gtttaatgcc aaaagcgctt cttcgtatgc 2326021 attgctctta atcgtattct ctgtgccgat gacaccgata tgctgattat ccgtcacttt 2326081 tatcgctgct ctcgcaccag gctggatgac tccgaccacc ggtataccga cgctgcgctg 2326141 gatgtcatcc aaagcgatcg ctgttgctgt attacaggcg atcacgagca ttttgatgtg 2326201 gtggttttcg agtaaataat tcgtcagctc ccacgtatat tgaagcacct cttcttcagg 2326261 gcgcggcccg taaggacacc gtttcgtatc cccgacgtag ataatatttt ctttaggtag 2326321 ctgtctcatg atttccttcg caacggttaa accgccaacc ccggaatcaa tgactcctat 2326381 tggttgttcc aacaaaatcg cctcattttc tcttcatttc atgctgcagt ttcatcaaag 2326441 atttttcgaa gatggctatt tcttcatctg taaacgattc gaacatatca cgcagatatt 2326501 cctgtctttt tgtaatgacc tcttggataa tccgttctcc ttcaggcagc agatgtatcc 2326561 tgacaacacg tctgtccgcc gggtccttga cccgctcaac aagctcattt ttttgcatgc 2326621 ggtcgattaa gtccgttgtc gtgctgcatg ccagatacat tttgcccgat aattcaccga 2326681 ttgtcatatc tcctaattca taaagccatt gcaagccgac aaattgcggc ggcgtaatcg 2326741 catattggtt aaggatttct cgtccttttt gcttaatgat cgcggcaatg tggcggagtg 2326801 acttttcaat atccgcaaca tgctccaaag gttttgatgt catttgtcca tccctcactc 2326861 aaggatctct tacgcacaaa agcgttccgt gtctattttc cttctttttt gaagaaaatg 2326921 caagactcgc aggagagaaa tagaggactt tagtcaaaca acatcaagaa ataaaattta 2326981 atttatgact tgcctacgtt ttgcacagca ttccaaatat ggtttcgaat gttccaaaca 2327041 aacagcaata accggctcct tccaaaagaa ggaataccgg caaggattaa agctctagct 2327101 cacccattct aagaagctca acaacggctt gcgaacgccc tttcacaccc aatttctgca 2327161 tggcatttga aatatggttt cgaacggttt tctcactgat aaatagctcg cttgcaatct 2327221 cctttgttgt cttatcttga acgagcaatt cgaacacttc tctttctctt ttcgttagca 2327281 gcggcttcga ttgaaattct ttctccttca agtattgtaa ccctccttgc taaggtgaga 2327341 gcgaatcaga aacgaatggg ttttgatata gtcgagatat catatgtaag aagggcgcag 2327401 gaggtgacgt ttacaagata attagtttat cgtgtatgaa gaagcgtttc tttctcctca 2327461 tccgtccagc tgacagcctt gccgctttcc tttgagactt gaaccatcac gactgccccg 2327521 gtgaagcagg gttcgccttc gaggttctct ccgagatagt gcaaggtaag agatgaactg 2327581 ccgactgcgc ttgttttcac atagatgcgc aactcttcat aaggcatgac ttggcgcaaa 2327641 taatcgcatt gctggcttgc cacgactgtc atggtctgtt tgttttcact catcatattc 2327701 agctttttaa aataagaaat ccgcacctcc tcaaaatata taaaaggggt tacattattc 2327761 atatgcccaa acatgtctgt ctcggaaaat cttacggata ccttattgaa aaaagaaaag 2327821 gatgttttcc attcttgaaa cggcatatca atataagcgg gaagcttcat cttttttcat 2327881 ctccttattg tttaaaaaaa cctctcccat gcggaagagg ttttttcttc ttatactctg 2327941 tcgcttccga agaaattgcg gaacgcttgt aagtttgtat ctctattcaa ggctgcaatc 2328001 gaagtggtaa gcggaatccc cttcggacag gattgaacac agttttgcga gttgccgcaa 2328061 tctgcaaggc cgccttcatc cattaatgct tctaatcgtt cagatttatt catggcgcct 2328121 gtcggatgcg cgttaaacag gcggacttgc gacatcggtg caggccccat gaacttcgat 2328181 ttgctgttca cattcgggca agcttcgagg cagacgccgc atgtcatgca ttttgataat 2328241 tcatatgccc attgacgacg tttttccggc attctcggcc ccggtcctaa atcgtacgta 2328301 ccgtcaatcg gtatccacgc ttttactttt ttcaatgaat caaacattct gctgcgatca 2328361 acctgcaaat cacgaacgac tgggaatgtt ttcattggtt ttaaacggat tggctgttca 2328421 agctggtcaa taagcgccgt acaagactgg cggggttttc cgtttataac cattgaacat 2328481 gcgccgcata cttcctcaag acagttcata tcccatgtga caggggttgt cttctcacct 2328541 ttgacattaa ccggattccg gcggatttcc atcagagcgg aaatgacgtt cagattcggg 2328601 cggtatggaa tctcaaattc ttcatcataa ggcgtgctgt cagctgtatc ttgacgtgtg 2328661 ataataaatc gtatggtttt ttgttcactc atgattattt cgccaccttc ttcttcgagt 2328721 aatcccgttt ccgaggcgtt atcagtgata catcgacatc ctgatactca aattccggcg 2328781 cttcatacgg gcttacatgt ttagccattg ttgttttgag ccattcatca tcattacgtt 2328841 caggataatc cggtttataa tgggcgcccc ggctttcatt acggttgtat gcgccaaggg 2328901 taatcaccct cgcaagctga agcatgttcg agaactggcg tgtgaacatc gctccctggt 2328961 tgctccattt tgtcgtgtca ttgatgttga tctttttgaa gcgctccatt aactcctgaa 2329021 ttttgtcatc cgttttcaaa agcttgtcat tatggcggac aaccgttacg ttcgccgtca 2329081 tccactcacc gagctctttg tgaagaacat aggcattttc ggttccgtcc atactcataa 2329141 tatcagccca tttttcttct tctttcttaa cgtgagcgtc gaataaagat gaagacatgt 2329201 cttccgctga agattctaag ccgtttacat atttcaccgc attcggaccg gccaccatgc 2329261 ctccgtaaat cgcagacagc agggagttcg ctcccaagcg gttgccgccg tgcatagaat 2329321 aatcacattc cccagccgca aacagtccag ggatatttgt catttgatcg taatccaccc 2329381 ataaaccgcc catagaataa tggaccgccg ggaagatttt cattggaagc ttacgcgggt 2329441 cgtctcccat gaatttctca taaatctcaa tgatgccgcc aagcttaata tcaagctctt 2329501 tcggatcttt atgagacaga tcgagatata ccatgttttc accgttaata ccgagcttct 2329561 ggttcacaca cacatcaaat atttcgcgtg tcgcaatatc acgcggcacc aggtttccgt 2329621 atgccggata tttttcctcc aggaaatacc atggtttgcc gtctttatat gtccacacgc 2329681 gcccgccttc accacgcgct gattcactca tcagtcttag tttgtcatcg cccggtatgg 2329741 ctgtcgggtg gatttgaatg aattctccgt ttgcataata cgctccctgc tgataaacga 2329801 ttgacgcagc agatcctgta ttaatcatgg agttcgttga ttttccaaag atgattcccg 2329861 gtccgcccgt cgccataatg acagcgtctg aacggaagga ttcaatttgc atgtttgtca 2329921 ggttttgtgc aacaattccg cggcaggttc tgtcatcatc taaaacagcg ccaaggaatt 2329981 cccagccttc gtattttgtg accagacccg caacttcgta tctgcgcact tgctcgtcca 2330041 gtgcgtaaag cagctgctgt cccgtcgtcg caccagcata agcagttctg tggtgctgtg 2330101 tacccccgaa tcggcggaaa tcaagcaggc cttcaggcgt ccggttaaac atgacgccca 2330161 tccggtctaa taagtggatg atcgaaggcg ccgcttcaca catcgccttg accggcggct 2330221 ggttggcaag aaagtctccc ccgtataccg tgtcatcaaa atgttcccac ggagagtcac 2330281 cttccccttt tgtattgacc gctccgttta tgccgccttg cgcacaaact gaatgagaac 2330341 gtttgacagg aacgatggaa aacaatttaa ccgccattcc tgattccgct gctttaattg 2330401 tcgccatgag gccggcaaga cccccgccga ctacgataat gcttgattga ctcatgatag 2330461 cccctctccc tctagtaatc tagtactctt aaacaaatgc aaaaatcgct tttaagccta 2330521 cgtatgacag tgcaacaaaa ataatcagcg taacgtatgt cgaaattctt tgagaacgag 2330581 gcgttaccgt gatgccccat gtaacagcga aagaccataa accgttcgag aagtggaaaa 2330641 ttgttgataa aacaccgaca atgtaaaaac caagcatagc cggagagctc aaaatattcg 2330701 ccatcatgtc gaaattgacc tcagcaccca tttgtgcggc aatgcgggtt tcccacacgt 2330761 gccagctgac gaaaatgagg gtgatgatac cggttacacg ctgcaggacg aatagccagt 2330821 ttctcatgta gctgtattga ccggcgttat ttttcgcagt aaacgctatg tacacaccat 2330881 aaactgcatg ataaattaat ggtaagaaga taataaaaat ttccaaggca tacctgaaag 2330941 gcaggctatc cataaaatga gcagcgctat tgaatgcttc agcgcccctt gcggcaaact 2331001 ggttgacgac taaatgctga ataagaaaga tgccgaccgg tatgacgcca agcaaggaat 2331061 gcaatcttcg aaaataaaac tctctgttcc cagacattac tttaccccct gtttgataag 2331121 tgcgaaatgt gctaaatctc ttcccccact tctttcaatt gtaagcactt tattaagatt 2331181 tattgacaat ttcattttac tcctccctca aaagggcgtc aagaaaacgc gtacataaat 2331241 tataattttc cgaattgatt agttgattga aaaattttat tttatcaata tatatttctt 2331301 gcttaatttt tcataagaat tacaggatca ttctgtaatc ctcccccctg tttgagctat 2331361 aatatacgca ggagagaggg gagacagata tgaagtctaa atttgaagca tctattgaca 2331421 acctaaaaga aattgaaatg aacgcttatg cctacgaact aatacgagag atcgttctcc 2331481 cagatatgct tggccaagat tactcttcca tgatgtattg ggcaggaaaa catctcgccc 2331541 gtaagtttcc tcttgaatca tgggaggaat ttccggcctt ctttgaagaa gcgggctggg 2331601 gaaccctcac caacgtaagc gctaaaaaac aggagcttga atttgaactt gaagggccga 2331661 tcatttccaa ccggcttaag catcagaaag aaccttgctt tcagctggag gctggtttta 2331721 tcgctgaaca aattcaattg atgaatgatc agattgccga atcatatgaa caagtgaaaa 2331781 agagagccga taaagtggtt ctgactgtga aatgggatat gaaagaccca gtgtaatcaa 2331841 aaaggcggtg actgcatagt cccgcctttt tgattgtcat tacacagctg aagggtgttt 2331901 tgaaagctca aatgcatcgt gaagcgactc gactgctttc accatgtcat tttcgcttac 2331961 gactgttgac actttgattt cagatgtgct gaccattttg attaaaatgt ttttttgcgc 2332021 cagtacagca aacatttcag ccgctacacc gggatttgag accatgccgg atccaacaat 2332081 agatacttta gccaatttgc tttctgtctc gattttctca aattccagcg cgtctttata 2332141 ctcttcaagc accgcaacgg tttggtctgc atcttctgtt ttgacagaga aggaaattcc 2332201 agtcttgtcc tcggcctgcg tttggataat gatatccacg tttatgtttc ttttggcaag 2332261 tgttgtaaaa atagtagaca aagttgtcag gccgctagtc agcccgtaaa tggttactct 2332321 tgtgatttga tcttcaaatg caatgcctct gacaattaaa ttctgttcca tggatgattc 2332381 ctcctcaatt aatgttcccg cttcggtttc tgtacttgaa cgcacttcta acggcacttg 2332441 gtaatttttc gcgaactcaa ctgctctcgg atgaagaaca ccggcgccta aattggcaag 2332501 ctcaagcatt tcatcgtatg agatgccctc aagttttctc gctgatttca catagcgcgg 2332561 atcggttgta aacacgcctg gcacgtctgt gtatatgtca catttatcag cttttaaagc 2332621 ggcagccaaa gcaactgctg ttgtatctga accgccccgg cccaatgtcg taatttcaca 2332681 atcctctgtc atgccttgga atcctgcaac aatgacaatt tttccttttt caagctggtc 2332741 tgctaaaacc gaagtgtcga tatctgtaat tctggcgttt ccgtgaatgg cctccgtacg 2332801 gattcccgcc tgccagccag tataagacac agcgtcatag cctttttcct gcaatgccat 2332861 tgaaaggagt gaaatcgtga cctgctcgcc tgtcgccagc agcatatcca tttcgcgttt 2332921 gctcggctgg tcagaaatag cttttgcaag gctgaccaat tcgtcagtgg attttcccat 2332981 tgctgaaacg acgacaacga cttgatggcc tttctgtttt tctgcaattg cgcggtttgc 2333041 cgcattttga attttttcga ctgagccgac ggaagtgcct ccgaattttt gtacaataag 2333101 acccatgtat taccaccctt tacattttgg ttcgtgcggg tgaggagaaa gagcgctttg 2333161 tccacaataa aaaaagcaat gagaggaata ctctcattgc ttatcaatta atcatcataa 2333221 atgattatga acaacgagat agccctccaa gaaaatgatt tcttgacagc cttacattta 2333281 ttcaatgcac ggccagcaaa taataccgat ggggttttat ttgcttcggc gacgctcccc 2333341 tttcagcctt tttcacagaa tccatctttc tccaaaggca tactcttgaa gttcgcacct 2333401 ctatcttcac catataacac gatctaacta tgaaattagt tcacatttta tcagatctta 2333461 tttaaaagga caacattatt tttgcaattt gtcgtaaagg agctgagccg ccgctgcggg 2333521 aacaccggct tttttgatgt cctcaaggct tgcttccttc atttttttaa cggaaccgaa 2333581 atgctttaac agcattttct ttcttttctc tccgataccc gggatgtcgt ccaaaacgga 2333641 ttgaaacgcg ctttttcccc ggatttgcct gtgaaaactg attgcaaaac ggtgcacctc 2333701 gtcctgaatg cgctgcagga ggtaaaattc ctggctgttt cgttccagat acgccacctc 2333761 cagcggatca ccgatcagta aatttgaggt tctgtgtttt tcatctttcg ctaaaccggc 2333821 gatcgggata tccaagccga gttcattttc aatgacatcc cttgctgcgt tgatctgccc 2333881 ttttcctccg tcaatgataa tcagatcggg cagcggcaga ttctcacgaa gcactctcgt 2333941 atagcgtctt ctgacaacct ctctcataga accgtaatca tccggccctg taacagtttt 2334001 gattttatat ttgcggtatt cctttttgta tggtttgcca tcgataaaca caatcatcgc 2334061 ggaaaccggg tttgtcccct gtatatttga gttatcaaac gcttcaattc tgtgcggcgt 2334121 ataaatattt aatgcctcac ctagtttctg cactgccccg attgaacgct cctcgtcccg 2334181 ttcgattaaa gagaattttt ctttcaatgc gattttcgca tttttatggg caagcatgag 2334241 cagttctttt ttcgggcctt ttttcggctg gtgaacgttt gtttccagta gctgctcgat 2334301 catagattga tctatgctgt ccggaactaa aatctccttc ggaaggaagt ggttgttttt 2334361 tgaatagaac tgcccgatga acgtgaggaa ctcttcatct gcttcctgat aaagcgggaa 2334421 catgctgaca tcgcgttcaa tgagctttcc ttggcggatg aaaaagacct gcacgcacat 2334481 ccagccctta tcgtacgcgt acgcgaacac atcacggtcg actagatcgt tcatcgtcat 2334541 tttttgtttt tccatcgttg attcaatatg ggcaatttgg tcacgaagct cttttgctcg 2334601 ttcaaactca agattctcag cagcttcatg cattttctct tcaagctctt ttttgacctc 2334661 attatagccg ccccttaaga aacgtgtaat gctttcaacc agctctctgt tcgtctcttc 2334721 ggaaatatcc tttacacacg gagcaaggca ttggcccaga tgatagtaaa ggcacactct 2334781 gtccgggagc ttggagcatt ttctgagagg atacagacgg tcgagcagtt tttttgtttc 2334841 ccttgctgcc tgtacattcg gatacggccc gaaatagcgc cctttgtctt ttttgacatt 2334901 gcgggtgaca atcagccttg ggtggcgttc atgggtgagt tttatgaaag gataggtttt 2334961 gtcgtctttg agcatgacgt tgtatttcgg atcatgcttt ttgatcagat tcatttctaa 2335021 aataagcgct tcaagattgg aggacgtcac aatatattca aaatcctcga tttccgtcac 2335081 aagcctttgg gttttcgcgt cgtgagaacc ggtgaagtag gagcgcactc tgtttttcag 2335141 cacttttgct ttccctacgt agatcacagt ctgctgccgg tccttcatga gataacaacc 2335201 cggttgatca ggaaggaggg cgagtttttc tttcagttgt ttgttcatat gttacccttc 2335261 cttatgttta atcctttatt tccagtttaa cacgaacgtt tgtttttctc tatggttcac 2335321 aattggcgaa taaaaaaagc gatccctcaa tcggaatcgc tctggcatgt aagcagcgga 2335381 aaattaaaga tgtttgttta caagctcttg aagcgcttct tttggtttga agccgactga 2335441 agtttcaact acttcgccgt cttttaacac aagaagagtc gggatgctca taacgccgta 2335501 ttttccggca gtttcttggt tttcgtctac atcgattttt acgattttca gtttgtctcc 2335561 catttcttga tccaattctt caagaacagg tgcaatcatt ttacaaggtc cgcaccaagg 2335621 agcccagaag tctgccagta cgacgccttc gcttgtttca gctgagaaag attgatcagt 2335681 tgcttttacg atagccatta ttgaattcct ccaatgtgaa atgatgattt ttagtatagc 2335741 atctcccatt cgttcacgct attttaatgc ttacaaatta ttttttcctg atcacagccg 2335801 gtttactcat ttttatatgg ttgaatggga tatgctcttt ttttaaaaca caaatctgat 2335861 aatggccccg atcactacaa ttgccccaat aatcattaaa atggtacgaa gcataagatc 2335921 acatctcctc ttcactgtca tgtactttac catgccctgc cggagctgtt ttaaaacctg 2335981 aaaaagagcg ccggcatgaa gctccggcgc tcttgcgcga ttaagaatca gcacgcagcg 2336041 taagtaagac gactgacatt ggcgggagtt ttactttcag tttgtttttg ctgagcgtgt 2336101 attgtctgaa ggattccggt ttgacatgat gaggatcgtc aaacgtgtta tgcgcattca 2336161 ttttttctgc cgtaagaatg actccggaat ggtccgctgc cttgtgtagg cccctcagct 2336221 cgatttccgc ctctgctttg ttttggtgat cgatgttgca aattgtgata ttgatatcgc 2336281 cttcagcttg tttcgacgct gaaatgctga tttgcggaag cgtttcaccg ttccattcat 2336341 agtcggcaga cattgtctct gtggctaaaa gagaagcgtc ctggtgcacc ttaaacatat 2336401 tgaatacatg gtacgtcggt gtcaaaagca tccgctctcc ctcagtcaaa atcatcgctt 2336461 gaagaacatt tactgtttgg gcgatgttgg ccatttgcac ccggcggcaa tgctgatgga 2336521 aaatgtggaa atgagaagcc gccaccagtg catcacgaat ggtgttttgc tgatataaga 2336581 aaccgggatt cgtgcctggc tcgggatcaa accacgtgcc ccattcatca ataatcagcc 2336641 cgacccgctg ctccggatcg taccggtcca taatcgtgcc gtgtttttga atcaattcat 2336701 cgatgtattt ggcttttttc atcgtaataa accattcatc ttccgtgaat tctgtggctg 2336761 atcctttgcc cttccagaaa tcccccggaa tcgtgtaata atgaagactc aacccgtcca 2336821 tcaggccagc ggcttttttc ataagcacgt ccgtccaatt aaaatcatcc acatttgcgc 2336881 cgcctgcaat tttataaatg tcattcccgc tgtaattgcg gacataagtc tgaaaacgcc 2336941 ggtacagatc tgcgtagtat tcgggatgca tgttgccgcc gcagccccag ttttcattgc 2337001 ccacgccgaa atatttcagc ttccaaggct cttctcttcc attttgcttt ctccagtctg 2337061 acatcggcgt gccttcttca aatgtcatat actcaatcca ctccgacatt tcctgaacgg 2337121 ttccgcttcc gacattgccg caaatatatg gctcgcattc aagcagctcg caaagcatca 2337181 taaattcatg cgttccgaat tcatttgatt caattgtacc gccccagtga gtgttcagca 2337241 ttgtcttacg gtcaccgaca ccgtttgccc aatggtattc gtccgcaaaa cacccgcccg 2337301 gccacctaag gacaggaatg tgcagctgtt tgagcgcctc cagcacgtcc tttcgtatcc 2337361 cgttgatatt ggggatgtct gagtccgttc cgacccagat cccctcataa atccctcttc 2337421 ctaaatgctc agcaaaatga ccgtatatat ttttgttaat ggttcctttt gcgatatctg 2337481 tttgaatcac tgcttgatgt tcagacatgc ctctgatcat tcctttcata cggatatgaa 2337541 aagcaccaca gtcaaatatg tgatctgtcg tttgcctgag gagtcagcat gaatgtaagc 2337601 gcttttaaag taaccatatt atatatgttc gtacatgtca acgacatttt ctattgtttt 2337661 tatatttgta cgtatgtatt tataaatatg aaaaaacccg gacttttaaa gtccgggatt 2337721 tcctttatga gtgtatattc agctgtttga attcctcagt taataacggg acaacttcaa 2337781 ataaatcacc gacgatgccg taatccgcta ttttaaagat atcggcttcg gggtctttat 2337841 tgatggcgac gatcaccttg ctgtttgaca tgccggccaa atgctggatg gcgccggaaa 2337901 tgccgcatgc aatgtacaaa tccggagtaa cgactttccc ggtctgcccg atttggagag 2337961 cataatcgca ataatcagcg tcacatgccc cgcgagaagc cccgactgcg gcccctagca 2338021 cctctgcaag ctcctgcagc ggctgaaatc cttccttgct tttgactcct cggccgcccg 2338081 caacgataat tttcgcttcg gagagatcaa caccgtccgc cgtttttttc acgacctctt 2338141 ggataacagt gcggaggtca gtaagagaaa catcaatgct ttcgatgctc cccgatctgc 2338201 tggtgtcttt ttctgaagct tgaatgttat tggggcgaat tgttgcaaag atcatcggat 2338261 cggttgaaat gacgcgttca aaagctttcc ccgagtaaat cggccgtgtg aacacaacat 2338321 tccctccggt aacgcttaca tctatagcat cagaaattaa gcctgtttgc agacgggcag 2338381 caagcttcgg tgaaagatcc ttgcccattg ccgtatgccc gaagatgact gaatcaggat 2338441 tttcttgctc gataacacct ctcatgacct ggctgtaccc gtctgccgtg tatgttttca 2338501 gcttcgggtc ctcagcggta agaactttat ctgctccgta atgaataagc tcttgtgcaa 2338561 tgctttgtac attttcaccg atgagaacac cgatgacttc cccatctcct gaaatggttc 2338621 ttcctgcagc tattgcttca aaggtgacat ttcgcaattc cccatcgcgt atttctccaa 2338681 gcacgatcac tttttttccc attctaacat ccccctgttt ctttgaatgt ccaagtttta 2338741 aatgacttta gcttcgctgc ggagcaatga aacaagctct tttgcctgtt cagcaggctc 2338801 accttggaga agcttcccgg cttctttttt cggcggcaga aaacgttcaa tggttttcag 2338861 ctttggttca gcatcctctt cgtccagatc aagatcatca agttcaagct cttcaagcgg 2338921 ctttttctta gccttcataa ttcccggaag cgatggatag cgcggctcgt ttaagccctg 2338981 ctgagctgtg acaagcaatg ggagcgtcgt tttgattttt tcaacatccc cttcgacgtc 2339041 cctttctgct tctgcatcag tgccgttgat ttcgagtttg gtgatcgtag tgatacacgg 2339101 aatgtccagt agctcggcaa gccgaggcgc cacttgtcct gatcctccgt caatggcaac 2339161 atttccgccg agaatcaaat caaactcctg atccttcata tagtggtata aaacttgaga 2339221 aatggaatat tggtcgggtt catcaagatc atcttctatg ttgattaaaa cagcttggtc 2339281 acaacccatg gcaagcgccg tacgcaattc tttctccgct tcttcaccgc cgaccgtgac 2339341 agcggtgatc gtgccgccat gcttttcctt cagctggatg gcttcttcta tcgcgtactc 2339401 atcatatgga ttaatgatcc attccgctcc gtcatcctga atctttcctg tttcaatgac 2339461 gattttttct tctgtgtcaa acgtccgttt catcagtaca aatagattca tgatcatatc 2339521 cccttttatt cgcctttgaa ctgaggcttt cttttttcga gaaatgcctg gatgccttcc 2339581 ttggcgtcct ctgactcaaa tgcttcccca aatcgctttg cttcaagctt taagctgcct 2339641 tcataggaat acaccttgtt ggaataaaga agttcaagca aagatgccag cgtttgcggg 2339701 cttttctctg caaacttagc ggcaagtgct tttgcttttt caatcacttc tgcctcatct 2339761 ttcgctccaa ttgagacaag tccgagatca agcgcttctt ttccggatat cggttctcct 2339821 gatccgatga gctccagtgc tttggctgta ccgacatatc tcggaaggcg ctgtgtcccc 2339881 gcaaaacctg gaatgatacc gagattaagc tccgggagcc ccagcttagc atcttctgcc 2339941 gcgattctga tgtgacaggc cattgcaagc tccagcccgc ctccgagagc agcgccgtga 2340001 atcgctgcga taatcggttt tggaaaactt tcgattctct ccattaactg ctggccgcgc 2340061 tcagcgagca atgaggaatc ctcattgcct ttaagcgatg taaattcttt aatatcagcg 2340121 ccggctgaga aaaatcttcc ctcgccgtga atgataatgc ttcgtacgcc tgcatctgtc 2340181 tcacattgat caagacagga agacagctct tctaatatcc ggcttgaaag cgcgtttgcc 2340241 ggcggattgt gaatcgtcaa gactgccaca aattgatcaa ccgcaagtga aattgcattc 2340301 ataggacaga actcctttac ttattgtgaa ttccggatac caataattct aaaacgctgt 2340361 ttgaaagcgc aacgagatcg tacttttggt cattcatcac ccaagttgtc acagtttcgt 2340421 caatcgttcc aaaaatcatc tgccgggcga ggcggacatc gaggccttct tttatttcgc 2340481 ctgattgtat accttccgtc aaaatgccat ccaaaatatt taagtagcct tttaatattt 2340541 cgttgatttt ttggcgcagc tccaagttgg attggcggag ctcaagctgc gtgacaatgg 2340601 cgagattatg gtcacccgct aaaagggaaa aatgctttga aatcacaagc gccaatttct 2340661 ctttcgctgt tgctttttct ttaatgtcct cttccatccg ctcaataaat tgacccattt 2340721 tttctttgaa aagagaaatt aaaatatctt ctttgttttt aaaatagaga tagatggtgc 2340781 cgtccgctac cccggcttgt ttggcaattt tggatacctg tgactggtgg tagccgtttt 2340841 ctgcaatgac ttctactgct gcatcaataa tctgcatata ctttggccgt ttttgcttca 2340901 atgttcatcg ttccttccta tagaaatgaa tgactattca ttcataattt catgataaga 2340961 aggattttca ggtttgtcaa gtttattcat aggcgttctc tttttttatt tgatatgatg 2341021 attttcggtt tcttcttcaa gtaaacgcct tcttaaaatt tttcccaccg ccgttttcgg 2341081 cagctccttt ctgaactcat aggctttggg caccttatag ggagctagac gtgatctcgc 2341141 aaaagcgtcc agttcttctg tatcggcttt tgcgcctttc tttaatacga caaatgcttt 2341201 tactgtttct cccctgtagg aatcgggaac gcctgcgaca acaatttcct ggatggcttc 2341261 atgttcataa agcgcttctt ctacctcacg cgggtaaata ttgtaaccgc cggcaatgat 2341321 gatatccttc ttcctgtcag caatatagaa aaagccttct tcatccatat agcccatgtc 2341381 cccggtgaac agccagccat ctctcagcac tgcggcggtt tcctctggtt tattccagta 2341441 tcctttcatg acttgcggac cttttacaat gatttctcca tgctcatacg gagcggcaag 2341501 ctcacccgtc tcttcagaat agatcgcagc gtccgtactc ggccaaggac agccgatact 2341561 gcccggcttg ttttttcccc agataaagtt ggcgtgcgtc actggggatg cctcagacaa 2341621 accatagcct tccacaagct ttccaccagt caccttttca aatttctgct ttacctccac 2341681 ggggagcgcg gctgatccgc taagacagct tttaatggat gacagatcat aatgctgcaa 2341741 ttcagggtga tgcaaaaggc caatgtaaat tgtcggtgcg ccaggaaaga gcgtcggttt 2341801 gtgtttgtcg atgattttaa gtgtttcgag cggatcaaac ttaggaagaa gaatcatttc 2341861 gaagcctagt ttaatcgaat agttcatgac tgccgtcagt ccgtagacat gaaaaaatgg 2341921 aacgatgccc agcacttttt cagcgccttc tttcacgtca tacatccaag cggcgcacat 2341981 ttcagtattt gccaaaatat tttggtgcgt gagcatgacc ccttttggag ctccggttgt 2342041 tcctccggta tactggagga cagcgatatc atgctcagga tcgatcttcg ggattgtcag 2342101 gagttcagtt ttttcctgct tcatacagga agcgaacgtg tgaatgttag ctgttttgtc 2342161 aaagtcgata tgcacttttt gtttttgcgt cagcgggtaa agaatatttt tcggaaaagg 2342221 caaatagtct tttacactgg ttatcaaaat ctggtcgact attgataacg ttttcatttt 2342281 tattgccttc gggaaaagca aatctaaggt gatgattaca cttacctgag catctctaag 2342341 ctggtattca agctcatgct cggtataaag cggattcgtc tgcaccacga tgccaccggc 2342401 aaacaagacg ccataataag aaatcactgt ttgcgggcaa ttgggcagca taacagccac 2342461 tctgtctcct ttttgcaggc cattgcactg caaaaaagct gcaagtttaa gagcatccgt 2342521 cagaatgtca tgaaaggtga gtttttttcc ataaaacgat attgcggttt tatcagggaa 2342581 tcgtgcggcg gagtctgtca ggatggattg cagggtttta ttcggcaacg gaagctcatg 2342641 cgggatatcg ttgggatact cggcaagcca cggcttttga gactgcataa aacctcccct 2342701 ttcgatttta gagatccacc ttatcattat agcagatgga cggcaaaaaa aagaaaaaga 2342761 aaggtaaatc tttctttttc tcataatatg aacagatata taagaccaat taacaaaaag 2342821 attcccgctg cggcgagcag tattttcgca agcttttcca tctattctcc gtccccttat 2342881 attccggctg ccaccacaaa agaaagcccg acagaaatga caaatgaaat aaagccgaca 2342941 gcccggttat cattttcgat ttcctgatca attttaaacc gcggagtcaa aaactcaaaa 2343001 ataaagtagc tgatcagaag cataacaaac ccgtaaacgc cccagccgat catttgcagc 2343061 agcgaattat gctgggagat ggaatgctga aatacgtttg cgattcccaa aatttttccg 2343121 ccggtcgcca ttgccaccgc aagatttcct ttttgaatct cttcccagtt tttataagcc 2343181 gtcaccagct caaacacagt caaaaagagg acgaggcaga gaaccgcgac actgtaatat 2343241 gccgcgattt ccacaagctc gttttcccaa aaatcactca tggccatact cccttttatt 2343301 ttagttcaac aaccgtaacg cctgatcctc cctcacctgc ttcaccgaaa cgggaacttt 2343361 tgacgctgcg gtggtttttc agaagatcct gtacgccttt tcttaaagcg ccggttcctt 2343421 ttccgtggat gattgacact cttggatatc cggctaacac cgcatcatcc aagtattttt 2343481 caacccggct gagggcattt tcatagcgtt cgccgcgaag atcaagttca agcgatacgt 2343541 gatagtcctt tcctttgacc gctgtaatca ttttttcttt ttttggctcc ggagctgatt 2343601 tgataaactc cagatctttt tcttttactt tcatctttaa aataccgatt tgaacgttcc 2343661 attcattgcc gcctgttttt tcgagcaatg ttcctttttg cccgaaagtg aggactttca 2343721 cctcgtcgcc aggcttaaag tcgcgttttt gcgttttcgg cttttccggt ttcttggact 2343781 tttcaaaagc aggcatagcg ccttctaacc gtttcttcgc gttaatcagc tcgtgatcct 2343841 tgaaggattt gtgttcttct tttatggtgc gcaattcatg aataatgtcc tcggcttctt 2343901 tcattgccgc ttttactttt tcagcagcct gctgttctgc ctcttcaagc attttgtctt 2343961 ttttgctgtt aagctcgatg atttgctgct gcagctcttt atgcagtttt tccgcttctt 2344021 ttctgattga ttctgtctca gaaagctctt cttccgcacg ttttttgctt tgttccagcg 2344081 acgcaatcat cgtatcgact tcgttatgct cggccgtcat ttctgacttc gcctgcccga 2344141 tgatatggtc cgggagcccg aggcgttttg aaatttcgaa agcattgctt cgacccggca 2344201 caccaattaa aagtttatag gtcggtgaca gcgtttcgat gtcaaattca acgctggcat 2344261 tcatgacgcc ttctctgtta tagccgtacg ccttcaattc cggataatgc gtcgtagcta 2344321 acactcgtgc attggtgcga tgcacgtcat ccaagatgct catggcgagg gccgccccct 2344381 cctgcggatc tgtccctgca ccaagttcat cgaaaagcac aaggctgttt tcattgacct 2344441 gttctaaaat gccgacaata ttcaccatat gggatgagaa cgtacttaaa ctttgctcaa 2344501 tcgactgttc atcaccgata tcagcgaata cgtgctcaaa tactgccgct tctgaccctt 2344561 catctgccgg gatatgaaga cctgactgcg ccattaaggt tagcaggcct aacgttttaa 2344621 gggtgactgt tttccccccg gtgtttggcc ctgtgatgac aatggttgaa aaatcgcggc 2344681 caagctcgat gtcattggca acaacctgat caggcggaag caatggatgg cgggcttttt 2344741 tcaaacggat aaagccggtg tcgttcataa tcggttttgt cgctttaacc gcttttgcat 2344801 atctagcttt tgcaaaaata aagtcaagcg tctgcagcac ttgcaaatct agaaatagct 2344861 cctctgtata ctctgccgtt ttctctgtca gcacacgcaa aatccgttca atttcttgct 2344921 tttctttcac tttcgcctgc tgaagggaat tgttcatatc tacaatcgcc tgcggttcaa 2344981 tgaatagtgt cgcaccagag gatgaggtgt cgtgcacaat tcctccatag ctggatctgt 2345041 actcctgttt gaccgggatc acaaagcggt cattccgaat cgtaacaatc gtatcagaca 2345101 gcattttcga tgcggaagag gaacgcagca tcgactctaa ccggtctctg actcttgatt 2345161 cgagtgttct gagctgtgtg cggattcctc ttaatgtttc cgatgcatga tcaagcactt 2345221 ctccgtgatc atcaatgcag gaattaatgt cccgctctaa atcggacagc gtgataagct 2345281 gttcagcatg ctgatggatc agcggaatgt cgacaccgtc ttcagccatt tgcgtgataa 2345341 aatgtttcat ttgtttaact gcataaagca ggcctgagat ttcagtgaat tcagaaggac 2345401 tgagaacgct gccgatttcc gcccgtctta acgctcctct gatatctaca aggccgccaa 2345461 atggcgcttg gcctctcagc cggataatgt cagaagcttc gtctacttca tccagctgtt 2345521 ttttgatttc gtctatagaa gcagaaggct taagctcgag aagcatttct tttccgagcg 2345581 atgaagcggc atgcccaata acctgttctt tcactttatg aaattcaaga gctgataata 2345641 ctttttgctg cacgattgtg tgagcctcct tacttaatcg ttgcgcttca gaaatgcctc 2345701 tacgtcttta agcgaccggg cattcagaac gtttttcgtt tccgtccatc ctttgcgcgc 2345761 ggcagtaacg ccagttttca tatcgtctaa catctcaata ttatgggcat cagtattaat 2345821 caccaatgta accccttgtt cgtttgcttt cattaaatgc tctgtgcgca gatcaaggcg 2345881 cgcagggttg gcattgagtt caagcgccgt atttgttttc ctcgcaagct caatcagctg 2345941 atcaatatcg atttcgtaac cggcccgtct gccgataagg cgcccggtcg ggtgtgcgat 2346001 aatgtcaaca tgcttgtttg tcagtgccgt ctcaagccgt ttcataatca cgtgttccgg 2346061 ctgattaaaa ctggaatgaa tcgatgcaat aacgatatcc atttccgcaa gcacatcgtc 2346121 atcataatcg agcgtaccgt caggcaggat atccatctca acgcctttca aaatacggaa 2346181 gttttcaaac tctgcattca gcgcgtcaat ttcttttgcc tgctgcttaa gtctttctgc 2346241 agtaagcccg ttggcgacct ttaaatattg tgagtgatcg gtgatcgcca tgtattgata 2346301 gccttttttg atgcaggctt cagccatctc tctgatcgaa aatgcgccat cgctccacgt 2346361 tgagtgcatg tggagatcac ctttgatttg cccgagctct atcagttcaa tgctgtcgct 2346421 gtaggtttcc acttcctgtc cgctttcacg aatttccggc ggaatcagcg gcaggccgaa 2346481 gtgcgcataa aattcacgtt cactcggaaa tgttttgatc tctccggttt caactgtctc 2346541 aacgccgtat tcactgatcc gctcgccgcg ttctttggcg atttggcgca tcttaatatt 2346601 gtgatccttt gatcccgtaa aatgatggag tgttgtcgga aactgctctt ccgtcacaag 2346661 acggaaatcg acgcttgttt catattcaaa ggaaaggatg acggacacct tcgtatctcc 2346721 gcttgcgatc acgcttttga tgtttggcag ctcaagaagc tgctctctta cttcagccgg 2346781 atgatctgta gcaatgatat aatccagatc cttcaccgtt tcccgcgctc tgcggagact 2346841 tccggcacga gaaaatttga tgatatgcgt aaattgagaa agatgctcct caatttcccg 2346901 cgcgatccgg agggcgtagc cgatcgggaa ccgttcaggc tgttttccgg cttccccgag 2346961 cgcctgtaat attttttctt ccgatttttt gccgaagccc gcaagaccct ggaccttttg 2347021 ctgctcacag gcttccttca gagattctgc atcgtgtacg ccgagctctt tatacagctt 2347081 tgcgattttt ttgccgccga gccccggcag cttcaataaa ggcacgagtc cttccggcac 2347141 ttctttctga agcgattcga gcgtgcttga ctttccttca tctatatact ctttaatgac 2347201 gctgtacgtt ccttttccaa tgccggacag cgacatcata tcgtccattt ctgataagct 2347261 tcggtcgtcc tgttccagag ctgccgccgc ttttcggaag gcggatactt taaacgggtt 2347321 gtcccctttg agttccatat agactgcaat ggtttcaagc agccggataa tatctttttt 2347381 atgcatatca taacccccag acgttcacat atgtttccat catacttgaa aaaaacttct 2347441 ccggacaaga gaagtttttt tatgccccgt actgtgtcca cagctcttgt aaaagccctg 2347501 acaagtacgg tgtatggtta atgatcacat ttgcgagaga cgattgcccc atcatttgct 2347561 gcaacgcgtc taccggcaga acggatgcga catacagcag cacaaatgta aataaataga 2347621 cttctagaaa accgagaacg gctcccagca tctggttgat ttgtttaatc accggaatgc 2347681 cggctacaat actcaggaac gagccgatga ttctcagtaa gattttagca atgataaata 2347741 aaacgataaa cgcaatcgca ttatagtacg ctgcttccaa attccccgta aaaaaagaaa 2347801 gagccggctg tcccgctgaa aaatcgggtg cgggaatcca atgtaaatgc ggtgccacgt 2347861 ttttatagaa taaagccgca aaggcaattg ataaaataaa gctcgtcaag cggataaact 2347921 gcaggataaa accgcgtttt aaccccagta aagtccccat caggagcaag attaagatga 2347981 tgatatctag catagttgtt caatcctttt ctttaagctg acgctccagt ttttcacatt 2348041 tctcttgtaa tttgacataa tcgtgcacca catttaccgc tgtcagcact gcaagtttat 2348101 ttatatcaag gtatggattt ttttcattga tttctctcat tttatcatca acaattccgg 2348161 cgacatacct catatgggct ctgctttctt caccgacaat cgtgaagtgc tggccgtaaa 2348221 tgtcaacggt tgtttttgtt tttttgccgt cagacaacgt ttctcctcca ttccgcgaga 2348281 atcctagttc ttatcataac acgtttatta aatgaatgga aagacgagcc tcccgctgtt 2348341 atgatacact ggtatataca gcgaaaagtg taaaaaaagg agattattac gtgtcccatt 2348401 cagtgataaa agtatcgttg tctgctattg accaaatgaa aatgacgtac agcggttcac 2348461 ttacagcctc tgttccgcag ggagccgttt ttcaggcaaa accgcccggc tgtaccatta 2348521 cagcatatca atcaggtaag gtcttgtttc aaggaaaaaa cgctgcggca gaatccgcgc 2348581 gctggggaac agcagagcct caggaaaaga agaaaacggc caaaaagccg gctgatcccc 2348641 gctatgcccc tccggcagat atcgccggaa tgtctgttat cggttctgac gaagtcggaa 2348701 ccggagatta ctttggccca atgacggttg tatgcgcgta cgtcgacaaa accatgcttc 2348761 ctttaatgaa ggaactcggt gttaaggatt ctaaagattt aaaagatccg caaatcatcg 2348821 agattgcccg aaacctgatt aaaaccattc cgtacagcct gctggtgtta aagaatgaaa 2348881 agtataacag catgcaggaa aaaggcatga gccaagggaa aatgaaagct ttgctgcaca 2348941 atcaggcgat cacacattta ttaagaaaat tggatggagt aaagcctgaa gccattttga 2349001 ttgaccaatt cgctgagcca ggcgtctact tcaatcattt aaagggcaga gacattgtga 2349061 aggagcggac ctattttagc acaaaagctg aaggtattca cctggctgtc gccgctgctt 2349121 caatcattgc aagatattca tttttaatgg aaatggataa actatcacgc gcggcaggaa 2349181 tgacgcttcc aaaaggggcc ggtccgcacg tcgatgaagc ggccgccaag ctgatcctca 2349241 aaaaaggggc atctgcactc agaaccttta caaaactcca tttcgccaat acgcaaaaag 2349301 cgcagcgcct tgctgataaa aaacgttcat agaaaaaagc ttgcagattt ctctgcaagc 2349361 ttttttatca gcctcttaaa acagcttgat atgtgtcttc taacgctttc agcactttgc 2349421 tgtgcgcctt tgtcacttct tcttcagtca gtgtttgttc aggattgaca tactggagtg 2349481 agaaagcgac tgacttcttg ccttcctcca tatgctctcc ttcgtatacg tcaaatacgg 2349541 ttacctcttt cagaagcttg cccccggcct ctttaatgac gctctcgagc tgtccgcttg 2349601 tgacggtttt atctgttaca agagcgatat cacgtgtcac agacggatat tttggaatcg 2349661 ccgtgtaaac aagcggtgct gtttctgctg cgagcaacgc atgaagatcg agctcaaata 2349721 cgtatgtttc ctttatatcc agttcttttt ccaatgaagg atggacttgg ccgatgaagc 2349781 cgatcagaga accattcaat aaaatgttcg ctgttctgcc cggatgcagc tgtttgcgtt 2349841 cagactgtac aaattcaatg ctgtctagga cgttgagttt gtctaacagc ccttccacaa 2349901 ttcctttgac aacaaagaaa tcaactggtt tcttttcacc ctgccatagc tgcttgcgcc 2349961 ataatccggt aacagctcct gctacgcgtt ctgtttcaac aggttttgtg tcctcttcct 2350021 tcgttaggaa aacggagcca acttcgtaca gtgcaactga gtcagtctgc ctcgcaagat 2350081 tgtaagaaac agaatcaagc agatttggaa caagactgtg tctgagaatg cttctttctt 2350141 cactcattgg aagcgcaagc acagtattca gtgatttttc aatcgcaaac gctgtcgctt 2350201 tcttctcgtt tgtcagtgag taagtgatgg cttgtgataa gcctgcgcct tcaaggaagc 2350261 gtctgacttt acggcgtttt gcctgatatg gcgttaatcc gcctgtagtt cccgctgtct 2350321 caggaagcgt agacggaatg ttatcgtagc cgtacagtct tgccgcttct tcgattaaat 2350381 cctcttctat tgtaatgtca ccgcgccgtg atgggacagt cacaacgaga agatcatccg 2350441 cttcaccgac cgtaaaaccg agacgtttat aaatgctgat cagttcttct ttactgatcg 2350501 tcaggcctag aacgctgctc actttgtcag cagatacgtg aatgttattt gcttcgattg 2350561 tcaggtgatc ttcctcaacc gttccagcaa gcacctcacc gccggcatac agatggatca 2350621 gctgcgcagc ccgttctgct gcaagacgta cgcgtgccgg atcaattcct ttttcaaatc 2350681 ttacgcttga ttcacttctc aaaccaaggt ctttggaagc cttgcgaacc ttctgcccgt 2350741 tgaaatacgc agcctcaagc aaaatggttt tcgtatcttc ctgaacctct gactctgctc 2350801 ctcccatgac accggcaacg gcctgcgctt tcgttccgtt tgtaatgaca aggtgatcgg 2350861 cagacagctt acgttcttga tcatcaagtg ttacgatcat ttcattctca gctgcttttc 2350921 ttactacgac ttccttagag ccaaatctgt cataatcaaa cgcatgaagc ggctgtccgt 2350981 attccaacag gacaaaattt gtgatgtcaa cgacgttgtt gtgcggacga atgcctgcat 2351041 tcatcagctt tgtctgcatc caaagcggtg acggagcaat cgtgacattt ttaatgattt 2351101 ttgcagtgta cagcgggttc gcttcttgat cttcaatttt gactgaaatg taatcagacg 2351161 cttgttctga agcagccggg taatccgttt gcggaagctt tacctcagtg tctaaaatcg 2351221 ccgcaacctc gtaagcaaca ccaagcatgt tcatggcatc cgcgcggttt ggcgttaaac 2351281 ccagctcaag aatcgcatcg tcaagctgta aagccgctaa ggcatcgctt cctgtttcag 2351341 cgtcattcgg gaatacgaaa atgccttctg catactcctt cgccacaagt ttgctttcga 2351401 taccaagctc ctgtaaggaa cagatcatgc cgtttgattc ttcaccgcga agcttggctt 2351461 ttttgatttt gaaattgccc ggcagcaccg ctccgactgt tgcaactgcg actttttgtc 2351521 ccttatccac attcggcgcg ccgcaaatga tttgtacagg ggcttcagct ccgatatcca 2351581 caaggcactt attcagctta tcagcattcg ggtgctgctc gcgctccagc acatggccga 2351641 tgacaacgcc tttgatgcct tctcctttgt attcaattcc ttcaacctca ataccggctc 2351701 ttgtaatttt ttcagcaaga acagccgggt ccatgccttt taaatcaaca taatcctcta 2351761 accatttata agaaacaaac atccttgcat cctcctctta cgcctgttta aactgcgaaa 2351821 taaatctgac atcgtttgta tagaagtggc ggatatcatc aatgccatat ttcagcatcg 2351881 cgatgcgctc aacacccatt ccgaatgcga agccctgata ttccttcgga tcaaagccag 2351941 ccattttaag cacgttcggg tgaaccattc cggcaccgag gatttcaatc cagcctgttc 2352001 ctttacatac tgagcagccg ttcccaccgc atttaaagca tgtcacatcc acttctactg 2352061 aaggctcagt aaacgggaag aagcttgggc ggagtctgat ttcacggtct tgcccgaaca 2352121 tttttttcgc aacaagttca agcgttcctt ttaaatcact catgctgatg tttttgtcaa 2352181 cgacaagccc ttcaatttgc ataaattggt gagagtgcgt cgcatcatcg ttatcacggc 2352241 gatatacttt acccgggcaa atgattttaa cgggaccttt gccttcatgc ttttccatcg 2352301 tacgtgtttg gacaggagaa gtttgcgttc tcatcaaagt ttcctctgtg atgtaaaagc 2352361 tgtcctgcat atcgcgcgct gggtgttctt tcggaagatt gagcgattcg aagttgtagt 2352421 aatccgtttc aacctctggc ccttcctcga ctgtgtagcc cataccgata aataaatctt 2352481 caatttcttc aatgacaaca gtgagcggat ggcggccgcc gactgcaaca gggttccccg 2352541 gcagcgtgac gtcaattgtc tgtcctgcaa gcttctgttt catttcctct tcttcaagct 2352601 tctcgttttt gtcagcaatc gcattggcaa tacgctccct tacttcgttc gcgagcgccc 2352661 ccatttttgg acgttcctca gcagaaagct tgcccattcc gcgcagcact tctgtaatcg 2352721 gccctttttt tccgagatat tgcacccgaa tatcattgac aaccttcaat gagcttgccg 2352781 cttctacttg ttctaaagct tcttgttcca gctgttttag cttttcttcc attttgcatc 2352841 ctccttttat gtaaacaaac cgtcatatgt ctttggaaaa taaaaaaaac ccgtcccttg 2352901 tacaagggac gagttgtggc cgcggtacca cccttatttc agacagactg atgctgtcgt 2352961 cagcttcatt gacataacgg aatcagattc cggttcacct ttacgcgcag tgtacgcggt 2353021 cccggcgaca actcaagagg tgaagccaat ttccggctgc gttaaaaatg ctctcagtca 2353081 gcggcatttt ctccctggaa agcagttgat cagaaattga ggtcctctgt cacggttttt 2353141 gaaatattat gttctattat agagaaatcc aacgcttggc gcaacactat cctcgcaagt 2353201 gatacacgag gatggcagcc gcaaccgcaa cgtttagtga ttcagcctgt ccgtaaagcg 2353261 gcacgtacag gttcaaatcc gttttttcca gcaatgcagc atctacccct gcaccttcat 2353321 ttcctacaat gagcgcaaag gattcagact gaggaatctc ctggtaaggc gctccgtttt 2353381 gcagcgccgt gccgtatact tttacgccct ctgccttcaa ttcgtccaca tatgaaggca 2353441 ggtttcttct cacaacagga atatggaagt gagatccttg agcagatcgc agtgtttttc 2353501 cgttaaaggc gtccgccgtg ccgtcaccga gtacaaccgc atccaaaccg gccgcatcag 2353561 ccgttcgaat cattgtgcca aggtttcccg gatcttgaac agcgtcaatc agcagcacct 2353621 tgcgtgccgt tgccagcttt tcttcaggca tatggcacac agcggcaatc tgctgcggcg 2353681 tttcggtttc agtcacagct gaaaacgcat cttcactcag catatagcac tggataccag 2353741 tctcaagatc tgaaggaatc ctcgtttcat cctttacaag gatttctttc acaatgcccg 2353801 ggcttttcaa cgcctcttca acgaggtgtt ctccctctat cagaaatgta tttgtttttg 2353861 ttcgttcttt ttttgtgtga agctttttcc aatccttcac tttttggttt tttgccgatt 2353921 ctatttgttt cactgtctat gtggcgctcc tttttttaac atgatgttat tatatcgcaa 2353981 gaacagcaca taataaacca ggtgcagggt tagaatatac gtattacatt ttagaaaaag 2354041 gagcgtttta catggatctt aatttacgtc atgccgtcat tgccaatgtc accggcaata 2354101 atcaggagca gcttgagcat acaatcgtag atgcgattca aagcggtgaa gaaaaaatgc 2354161 ttccagggct cggcgtttta ttcgaagtca tttggcagca cgcatccgaa agtgagaaaa 2354221 acgaaatgct gaaaacgctt gaaggcggat taaaacccgc cgaataagac atgaaaccgg 2354281 gtgacagcgc ccggtttttt tcttatataa taaaaacatg atgaggggga acgccatgtt 2354341 tttacagccg ttattagcga aaaaaattat tgctgaagtt aaaaaaatgt acgaacgtga 2354401 agtcattatt gtaaacacgg acggtcttat tatggcaggc acaaacgatg agcgtgtcgg 2354461 acaatttcat gagggagcgc ttatctgcgc aaaagaaaga cgcagcgtga ttattacaaa 2354521 agaagatgaa acaaggttaa aaggagtgaa agcaggcata aacctccctg tattttttga 2354581 ccatgatgtg attgccgtct tcgggctgac aggtgagcct gcagagattc agccattcgg 2354641 agaactgctt cgaaaaatga cagaactgtt cattaaggaa tcgcggcact tagagcaatc 2354701 ccagtggcgt gagagaatgc tggagtcctt tatgatcgat tggctgcaat taaaggagtg 2354761 gtctcccagt tttcttgaga aagctcagct tcttggtgtt gacctttctt cccggcgcca 2354821 aatgattctt attcaggggt atgagtggtc acctcatgat attgaacaaa tggcacgcag 2354881 ctggaaatcc tcgtaccctg cggatttgtt catcaggtgg ggaaatgaac ggattttgat 2354941 taatcatgaa gtgccgcagc atgaacaaag ggatcggctt ttgcggaaaa tccttcacat 2355001 ttgttcgttt gccaataccg caagcagcca atatacagca gctggcgccg gaagggctgt 2355061 cgcaagctcc agcctgacag attcatacga gcaagcggaa aaagcgctgg ctgtcagcct 2355121 taagcgaaaa acgcccatat ttgaagagga tctgaagctt gatatgtgtc tgacggagat 2355181 cagcccggga acccgaaacg aatttccgca aagagtatta ggaaaggcgc tagagcatca 2355241 ggaacttatg aatacgatac ggactttctt tcatcacgat ttgtctttga aacaaaccgc 2355301 tgaagacatg catatacaca tcaatacatt gcgttatcgt ctggctaagg ctgaacagct 2355361 gacgggatta cgttttgacc gtaccgagga cgtcgtcacg atgtacgtcg cactctattt 2355421 tttagatcaa gatacaaaat agagagagtt tcagtttcat tttttgtatg tttctccatg 2355481 gaaggctttg ctttttttct tttacaatag attgaaagcg ttttttgaca gggggatggg 2355541 tgaaatgatc accaaggatg taaaggagca gctgattcag gtctccggac cagaaaactt 2355601 tgatgactcg aatgccggcc gtctcgtcta ttcatatgat gcgacgcctc agtatcagtc 2355661 tatgcctgat gccgtgattg ctccgaggaa tactgatgaa atatcacgca ttttaacaat 2355721 ttgcagcgaa catcgagtgc cgatcgttcc aagaggatca gggacaaacc tgtgcggcgg 2355781 cacgtgcccg actgaaggcg gacttgtgct tctctttaag cacatgaacc agattcttga 2355841 aattgatgaa gaaaatttaa ctgccacagt tcagccgggc gtcattacgt tggatatgat 2355901 ccgggcagtt gaaagcaaag gtttatttta tccgcctgac ccgagttcta tgaaaatatc 2355961 aactatcggg ggcaacatca atgaaaattc cggcgggcta cgcggattaa aatacggtgt 2356021 cacccgcgac tatgttattg gactggaggt tgttctcgca aatggtgaca tcatccgcac 2356081 cggcggaaaa ctcgcaaagg atgtggccgg atacgatctc acacgtcttt ttgtcggctc 2356141 agaaggaaca ctcggcattg tgacagaggc aatcgtcaaa ctcgttccaa agccggaaac 2356201 aaagaagacg ctgcttgccc tttatgaaaa catcgatgcc gctgctcaaa cggtatcgga 2356261 cattattgcc gcaaaaatta tacccgctac gcttgaattt ctcgatcagc ctacactatt 2356321 ggtgattgag gattatgcca aaatcggact tccgacaagc gcaaaagcag ttctgttaat 2356381 tgaacaagac gggccatttg aaactgttga acgggatatg gaaaagattg aggcgatctg 2356441 caaaaaaggc gacgccgtat ccgttcagac cgcacaaaca gaggaggaag cgtttgccct 2356501 gactgaagcc cggcgttctg cactttctgc cctagcccgc ctcaaaccga cgacgatttt 2356561 agaggatgcg accgttcctc gctcagaaat cgccaatatg gttaaagcga ttaatgatat 2356621 tgctgctaaa tatgatattt ccatctgcac ctttggtcat gcgggagacg ggaaccttca 2356681 cccgacatgc acgacagaca taagaaataa ggatgaaatg gaacgtgtcg aacaggcttt 2356741 tgccgagatt tttgagaaag cgattgaact tggcgggacg ataaccggag agcacggagt 2356801 cggggaaatg aaagcgcctt acttggaaat gaagctgaaa aaagaaggca ttgatgcgat 2356861 gaaagcgttg aaagcggcat ttgacccccg gaacatatta aatcccggca aaatgtttgc 2356921 gaaagatgcc agaaaacgtg tggtggcgga aagatgacaa cagaaaaaga aatgaaacag 2356981 atccaaaatg aatttaaaga gcgtatggat gaaggagagt tattaaattg tatgcgctgc 2357041 ggcttctgtc ttccttcctg tccgacctat atcgaatcgg gatttcagga aacacactct 2357101 ccgcgtgggc gcatcgcctt aatgaaagcc gtagccgacg gtatgattga accggatgaa 2357161 gatgtcgaac ggtcgctgtc actttgcctc ggctgccgcg cctgtgagcc tgtatgcccg 2357221 tctggcgtga aatacgggca gctgcttgag gaagccagag atattatcca ccaaaataaa 2357281 aaacactctc ttggtgaacg tgtcatgcga aagacggctt ttcacgagct gtttccgcat 2357341 caaaaccgca tgcgctcagc tgtaagcctt atcggtttgt atcagcgttc aggactgcaa 2357401 accgctgtgc gaaaatcagg catgcttcgg gtcctgcctg agcatttgcg gacgatggaa 2357461 gctgttcttc ctgatgttcc aaaaagcaaa gacatgaaac atcggccgcg tttcctgcct 2357521 tccattggcc ccatgaaaaa acgggtcgcc tttttttcgg gctgcttaat ggatacaatg 2357581 tttttaccga ccaataacgc cacattgaag cttttacagc tggcaggctg cgacattgtc 2357641 attccgcctg aacaggcttg ctgcggggcg cttcatggac acagcggtga aaaaaacaca 2357701 gggaaagagc tcgcgaaaca aaatatcgct gctttcgaag cattagacgt ggatgcagtc 2357761 attacaaacg caggaggatg cggagccttt ctcactgaat atgatcattt gctgaaggat 2357821 gaccctgagt ggtcggaacg ggctgccgct tttgttcaaa agctgaagga tttttcttct 2357881 gttttggttg aactcgattt ccatcaaatg gatctagcac tcgagacgcc tcaggtcgtt 2357941 acctaccaag attcatgtca tctaagaaat gtgatgcata cgtcacttga gccccgccag 2358001 cttcttaaaa gcatcaaagg ggcggaattc aaagaaatgg agaaagcaga cagctgctgc 2358061 gggtcagcgg gaatttacaa catcgtcgaa gttgaaatgt ctatgaaaat actggacagc 2358121 aaaatggctg ccgtcaaagc aaccgaagcg atcctcattg taacagcaaa tcctggctgc 2358181 ctgctgcaga tgaagctcgg cattgaacgc gaaggactaa gcggtaaagt cagagccgtt 2358241 cacctggctg atttgctatt agaagcagcc gggcacaaaa catcatgaga aagcccaaaa 2358301 cagacattgt tttgggcttt tgtgcgttat tccatcggac tgcaaatttc gatataatgt 2358361 ccatccggat cagcgatata ggcgaccgtc tgcccccatg gtttcacttt cggctccccg 2358421 ataatcgata cgccttgttc tctcatcctt ttgatgaccg cttctacatt ttcagtaaca 2358481 aacccgattt caaatgtgtt tgaagcagat gtatccggaa tgtccagcgc cgtgatgtct 2358541 ctggcgcttt cccgggtatt aagcgccaat atcgtagacc ctgtatcaaa ttcgacatac 2358601 gtgccgtgtt cagcacgaat cggcagtcct aaaatatccc ggtaaaaaat gaatagcccg 2358661 cttgctgtcc gatacgtata gaataagata tttcattgat agattcattg ccaacccctc 2358721 tcagcatttt caatagtcct tctagcccgg tatagatgct tccatcctta agctcggatc 2358781 tttccacatc tgcgcccatt ttttcacagc cgccacgata atgatgaagc ctaacaccag 2358841 catgatgata gataatacgc cattcaatac actatatcct gctgcttcag gattgagata 2358901 cacattgcgc accatccaat agcccgcata attgacagtg acatataaat aggcaagcgg 2358961 gataaggcaa gtcagaatgt accggcgttt atcggcgatt ttcagcacga tcgtcgctcc 2359021 gataatcagc cccactgaag ccatcagctg attagaaacg ccgaagagcg cccaaatgga 2359081 accgatatct cctgaataca gcaagtaccc ccacatcaaa caggcaagcg cgctggcaaa 2359141 tacagagccc ggaatccagt ctgttttctt cagcggctta tacacctccc cgaagaagtc 2359201 ctggatcaaa taacgggcga cacgtgtgcc ggcgtcaatc gctgttaaaa taaagaccgc 2359261 ttcaaacata atgacaaatt ggaaaaagta tgaggccaaa tggctgaaaa acggcattcc 2359321 ggtaaaaata taagtcatcc ctaccgcaag cgtgacggct ccccctgttc ttccttctaa 2359381 gtccaaaccg atttccccgc tcaattcagg caaatgtacg acattcatgc caagcgtacg 2359441 gaaaacctca ggcgtgctgt taatcgcaaa gtaatcagca ggctgtaaag cggtcgctgc 2359501 aatcagcgcc atgataccga caagacactc aacaagcatt gcgccaaacg caaccggctt 2359561 catatcactc catttattca gcattttcgg tgtcgttcct gagccgacaa aggcatggaa 2359621 cccagagatc gccccgcagg cgatggttat tgagatgaac ggccagacag gtcctgccag 2359681 caccggccct ccgcctttta cgaattctgt aaacgcaggg aacggaatgg acggattgac 2359741 gacaaacaca ccaacaatca aagcgataaa aacaccgatt ttcataaagc tgcttaaata 2359801 atcacgcgga gccagaagca gccaaacggg aagcgcagcc gcaaaaaacg cataaacagg 2359861 aagcgcgatt gcaagcgttt tcgtatctag cgttaaaaag tcaccgagcg cggtagtctg 2359921 tacccatgga ccgataaaga ctcctgccat taaaaagaga aagccgaccg ttgaagcgag 2359981 ctttaaattt cccgttttct tataaaataa gcccacaccc atcgcaatcg gaatcgtaat 2360041 ccccaccgca aatgttcccc atggattacg ttcaagcgca tgcaagacaa ccatcgacag 2360101 gcccgccatt gtgatcgtga tgataaacag catggacagt cctgtacaaa atcctgcaac 2360161 agggccaagc tcatccttcg ccacttccga cagcgatttt ccgtttttgc gcatcgatgc 2360221 aaacaacacc acaatatcat ggacggctcc cccaattacc gccccgatta acagccacaa 2360281 taatcccggc aaatagccaa actgcgccgc cagaattggt ccgaccagcg gcccggccgc 2360341 tgcgatcgcg gcaaagtggt ggccgaacga aacccattta tttgtaggca catagtcttt 2360401 cccatcctca agcgcatgag caggtgttgg cttgtcatca ttcactttga gaaccttcac 2360461 catcataaat gttccgtata aacgataggc aatagccaaa atacacattg atgctatcac 2360521 aattgtaacc gcattcattt tctcccatcc ccttttctgt ttttcataaa tatatcataa 2360581 tttcatggtg aaaagcggtc attttttcct atacaaaaag ccggctggaa tgggccggct 2360641 cgtggcagtt gaaagacaag ccggagagaa atctccggct ttgctattct tatgactgtt 2360701 ttttcaggcg gatcacattc caggaaagcg gcgtgaaatg agcagttaag ccgttttcgc 2360761 tgacagacga tgatccgttg gaatgcggaa cgacattttt tctgttatgc tggtttgttg 2360821 ctttgatatc ctgatgctca agtacgatgt gctctgcgat ttggtaggat tcaaagcctc 2360881 tgagcgaaat ctccgtctcc atctgatcct cagccttgtt taccgcaaaa atagtgagtg 2360941 tttcttcctc ttcagagtac acaacagcag catcaacata tggcacatca gtgaaatcag 2361001 aacaatcgta cttaggagaa gaaataagcg gtttcagtga ctcgcccctt ccgtaaacag 2361061 aagcatgcat gtatggatag aaaatcggct gtctccatgc ttctccgcct ttttccgtca 2361121 tgatcggcgc gatgacatta acaagctgtg caagacacgc aattttcaca cggtctgcgt 2361181 gctgcagcat cgtaatgagc agagagccga ctaataaggc atcttcaaaa ttgtaaatat 2361241 cctctaaaat cggacgcgca gtgatccacg gctcgacttt tttatcagcc tcatttgagt 2361301 ggtaccagac gttccattca tccagagaga gattgatagt tttcttgctg cgtgtttttg 2361361 cttttacata gtcacaggtc gcagcgactg atttgataaa atgatccaaa tccatagaac 2361421 gtgccaagta gtttggcaga ttgttatccc ggtttccgta gtaagtgtga agagagatat 2361481 agtcgacatg ctcatacgta tgctcaagca ccttcgcttc ccaatcgata aaggtcggca 2361541 taccgctgtt tgagctgccg caggcaacga gttcaattga tgggtcaacc cacttcatga 2361601 cctttgctgt ctctgcggca agccgtccgt attcatcagc tgttttgtgg ccgatctgcc 2361661 atggtccatc catttcgttt cctaagcacc atgttttgat gccatacggc tgttcatagc 2361721 catgcgatct tcttaaatca ctccagtaag agcctttcgg atggttgcaa tattcaacga 2361781 gattacgggc ggcatctatg cctcttgtgc caaggttgac ggccatattg acctcagtgt 2361841 tcaccttttt tgcccaagat aaaaattcat ttgttcccac ttcattggtt tctgtcgttt 2361901 gccatgccaa gtcaagccgt ctcgggcggt tttcgactgg tccgacaccg tcctcccagt 2361961 tgtatccgga taaaaagttt ccgcccggat agcggatgat gggaacctgt aattctttga 2362021 tcagcgactg gacatctttt ctaaatccat cttcatccgc ttcagggtga tcaggctcgt 2362081 atatgccttc atataccgca cgacccatat gttcgataaa cgagccataa atccgtttat 2362141 ctacttcacc gattttatat tctttgtcta caatcattcg cgcttttttc atcacacgtt 2362201 tcctccttca ttaacctttg actcccccta ccgtcaggcc ggagataaag tacttttgga 2362261 aaaacaagaa aatgataatc accggcaaaa tcgcaaatac tgagccggat ataagcatgt 2362321 cgtaattatt tccataaggg ctcagcaagc tggacagccc tattggaagc gtaaacattt 2362381 ctttcgaccg aagcacaatc agcggccaca agaagttgtt ccagctgttt aaggactgaa 2362441 ggataatcat cgcaccgaaa gccggtttca tcagcggtgc cataatcctg aaaaagatgc 2362501 cgaattccgt acagccgtcc atccttgcag agtccagcag atctcttgga aggccaagag 2362561 catattgcct gaaaaagaaa acagcaacag gtgaaacgat aaacggcaat atgacacccg 2362621 tatatgaatc gatcaagtgc agtccgacag taagtttaaa cagaggaagc atcatcactt 2362681 ccagcggaac catcataata atcagcacaa gaacaaagat gatatttctg cccttaaaat 2362741 cataaaccgc aagcccgtac ccgatcatcg aagaaaaaaa cagagtgagc acagtcgtaa 2362801 aaagtccgag tacaagactg ttaaaaaacc atttgaaata aatgctgccg ccattaaaca 2362861 gaaatgtgta gttatcaaaa ctcatcactt ttggatcaat atcaagattc agccccacac 2362921 gcaaaagctc agatgacggc tttaatgatc ctaaaagcaa acagaaaatc ggaaaaagat 2362981 acaataggct cagcatcata aaaaacaggg tcagcgcaat tctataaacg ctaaactgag 2363041 gactgtgccg caacatttat ccctccccct taaacgagcc tgacagcttt aatgaaatca 2363101 ggctgacaac aaggatcaca atcaaaagca caatgccgat ggccgctccg tatcccattt 2363161 cattgtaggc aagtccctgc tgatacaaat atccgacaag cgtcagacca atattacccg 2363221 gggaattatt ctgccaaagg acgtagcttt cctcaaacat cctgaagccg ccgatgatgc 2363281 tgatggtcag cacatatacg gttacaggct tgagaaacgg cagcgtgatg tgcagaaatt 2363341 ttttcattgt attcgcgccg tctatatcag cggcttcgta cagctctttc ggcacatttt 2363401 gcaaacctgc taaaaagtaa aggatgttga ttcccatcca tctccatgaa gcaagcagca 2363461 ccatcaaaaa catgccggta tgttcattgt tcatccagtt ctgaggtgaa aagccgagtt 2363521 taagtaggat ggaattggcc agagacgttt ccatttctcc gaagatcagc cgaaaaatga 2363581 tccccgcgac aatggttgag gtcaatgccg ggataaataa tgctgattta aatatatttc 2363641 taaatttgac cagctttgaa ttcaggaata tggccagaag caatggaaca ggaatcagca 2363701 cgatcagcgt ccaaaaggtg tattccagcg tattccaaag ggcggtatag aacgtcgggt 2363761 tgtttagcgc tgtataatta gacaatccga caaaggacac ctctcccggc aaaattcttt 2363821 ggaagctcat gatgaagaca ctaatgatgg ggtatagaaa aaatacgaga aaggataaaa 2363881 cgaatggcgc tgtaaacaga tagggcgccg ctttttttga ataaaacaga tctcgccagc 2363941 ctgattgttt cgcagctgaa ggaacgggat gaaccgttcc cgttttcaca ggtttcatga 2364001 gaacctcccc gctttcactt tttgaatggg attctatttc tgtttcagtt cacctgccgc 2364061 tctgtccaag gcttgtttag gcgttttttg ctgagattta agcgcgtcga acaatacgct 2364121 tctgttgaca aggtctgaag ccttggcaaa atcctcatgt aaataaattg gattgatttc 2364181 atccttgata tcgagcagca cagaaaaaat gcctgttccg ttttggaagt aatccgtgta 2364241 tttgtttttc tctttcaatt ccttggagct ccaaacatcc cagcgaagcg ggtcaaagcc 2364301 gagtacgctc cagagttttt tatttccttc ttcagagccc ttcgcaaagg ccaaaaactc 2364361 ttttgctaac tcaacatgct tggattgctt cggtacaaca gttgccgtac cgcccaaacc 2364421 tgccgagcgg tcgcccccct ctttccatgc cgggagcggt ctgatggcaa tcttcccttt 2364481 cagatcaggc atataatcga taaatcttcc catataccaa atcggcatga gaactgaagc 2364541 agctcctcct tggttcataa agccgtagta ttcttcactg tgatgcccgc cgcccggcgc 2364601 aggaatcatc gttttatcat tgatcatgtc ttttaaatat tgaagtgttt ttacgttggt 2364661 gtcattattg aggatcagct tgccgttttt atcaaaatag cctgagtttt gctgtgaaat 2364721 catagataag aacgttgcgg aatcatttgt ttccaccgtt cccatcggct tcccggtcac 2364781 tttgcgcact ttctgtccgg ctttatggta atcatcccat gttttaatat cgtcaggatt 2364841 gacgccggct tttttcatca catccatgtt ataaaacatg accgttgtcc ctacatgtgt 2364901 atcgagtccg taaagctttc cgtttttgct gtacaatgtc agccgcgcct caacgaattt 2364961 atcgcgatcc ttttcaatca gcggagtcaa gtcggcaagc ggtatgtcag agcccttcaa 2365021 aaagtttgaa aaacgggcca attcgacatc tgcaatatca ggaacgcctt ctcccgctat 2365081 tagggagata gataagttat cgtgcatttg tccatatgga taaacgaccg tattcagctt 2365141 aattttgcgg tcaggatatt ttttgttcca ttccttcacc atttccacat agaactgctc 2365201 atgaagcccg ttaaatgtcc aaaaggtcag ctcagtttca cccgatttgc cggatgattt 2365261 ttctgctgaa cacccggcaa tgactaatgt cagcaacatc atgagcacaa gaaaacagac 2365321 agtcattttt ttcatctgcg ttaccccttc cattcgaggt gcgggctatt catatagacc 2365381 atggttgatc agcgttttgt tttcattgat gattcttaat ccggtgcatc ggtctcttaa 2365441 ggtgtgcgcg tgtctgaagg catttttgac ggaatcctgc ccgacaccga tttcgtcaaa 2365501 atacgcaggg cctccggctg atctcagcca atcagccagc acttctcctc tcgggagtgt 2365561 ttgataagcc gattggatgg cttcccggcg gcttggtgaa aattcgttca gcccgtcatc 2365621 ctgagcgagc tttctgtatg tgtcagttaa taaaacagcg gcacagccca cctttgcccc 2365681 atgaagaatc tgaggccgtt ttttctccat taactccatt tcaatccaat gtgaaatatg 2365741 atgctcgccg cctgatgccg gtcgggaatg atctaatgcc agcatgacaa gccccgatac 2365801 aagtaaagac tccatcaaaa cccgtatgcc agtttccgtt ttcatcgcaa tgtcttctgt 2365861 gtgttcaatg caggcagcaa gcgcctcctg aacgatctta gctcctgcag gcgaataagg 2365921 ctcaccggca agatgccggg atatttccca atctgctaaa gacgtgattt taccgagcat 2365981 gtcaccaaag ccagccgcca ccattgactg cggtgccgct tttaatagat ccagatcagc 2366041 gaacagcgca gatggggcct tcgtttgaat ggttgttttc gtgccgtata aaataatcgg 2366101 cgcaccggct gatgtaaaac cgtctacaga tggagcagtc ggataagaaa taaacggcaa 2366161 atctctttga aacgccgcaa agcggacgat atcatgaatc gtgcccgaac cgactgcgat 2366221 catgacatcc gttggttgtt tcgtatggat cagcacatga atgagcgatc gttcatcagc 2366281 tgtcacatct ccggcttcat tttctggaat gatcaggcac tcggcctgaa atccttcttg 2366341 attcagtcgg ttttctaaat caattcctgc aatgcggtgt gtattcgcgt cgcagacaag 2366401 gacaatatgt tgattgtttt ttcgttttac ataatccaaa agcgaatcag ctgcttgctt 2366461 accgagaaca atttcttcaa cttttatagg caacgtcttt tctccggcgt tttcaaaagc 2366521 acgctgaacg tcagctgcga tacgattcat atcagaatcc cctcctcagc caatttggtt 2366581 acatccttaa tagaatccag cacataatcc ggcgtgtaca aacgctgttc accctgtttc 2366641 gcagaaccag ttagcactaa ggcgcttttc atgccataaa gcttccccat cgcaatgtca 2366701 gattcaatgc tgtctcctat aatcatgcat tcatgtgcgg acagccccat tgctgtacag 2366761 gcagcctccg ccatcagcca tgacggtttt ccgacaacaa gttcagtctt cgcttgtgca 2366821 gaagtctcaa ttgccccgat cattccggcc acatcaatgg catttccgtc ttcgttcgga 2366881 aaagagcggt ctttgtttgt agcgataata cgagcgccgc cggcagccgc ttgaaaggct 2366941 tgatttaaat cgtcgtacgt gagcgtttca tgaagggaga tcacgagcca atccgcttcc 2367001 ttcggttcgc tcgcgttctg cacaccggcc agcctcagct cgtcaaccaa gccttgctcc 2367061 ccaagcaccc atacctttga aaaacgataa tgttttttca gaaaagccgc tgtcacgctt 2367121 gatgacagaa caatgtcgtt tacgtccgtt tcaatccccg cgccaagaag tttttttctg 2367181 cacatggcac gggagatatt cccccggttg cttaaaaaga cgattttctt tcccattctc 2367241 ctaagcgttt tgatcgcttc tcttgctcct tcgatcaact catttcctct gaatacagta 2367301 ccgtccaagt caatcagaat gccagccggt gacacaggcg tatcatgact ggccataata 2367361 cgcatttgct ccgtgttttc gataaaaatg cttttcatgc aggactgtat tgattggggt 2367421 tacatccttg ttcagcataa tggagtgata ggccatttcg gcaaccgttt ctaatacaac 2367481 tgcgttatga atggcattta aggcgtcagt gccccagcag aacggtccgt gattattcac 2367541 gagcacaccc ggcacctgtt cgtaattatg atgctgaaag gtttccgcta tgacttttcc 2367601 tgtattcagt tcgtagtcat gaatgatttc ttcatcgtac atttctcgag tacatggaat 2367661 cgcactgtca aaataatcag catgggtcgt gcctaacgga gggatgtctc tgcccgattg 2367721 cgcccagctt gtcgcccatt gagaatgggt atggacaatt cccccgatat tcggaaaggc 2367781 tttatataga taaacatggg taggtgtatc tgaagaaggt ttaagcgagc cttcgacgac 2367841 ctctccatca aggttcaaaa caaccaagtc atcggctgtc aggtcgctgt attcgactcc 2367901 gctaggtttg atgacaattc tttctttttc acggtcaatg ccgctgacat ttccccacgt 2367961 aaaggttacc agctgatgct cttgaagctt caggttggca gccagcactt ctttttttaa 2368021 tgtttcaagc atgctccatc accctttatc aattcttttt ggcggcagat gaaaattgaa 2368081 gatttttgat cgttttcaga cgcttcatga catggttttc ttttccgaaa taatgaacca 2368141 gctctttata ttcagcgtac aatttttcat aaaccgcggc gttttcggca tttggcgtat 2368201 aagttatatc tttcagtttt cccatgttcg ccgctgcctt tttgatatca tcgtagccgc 2368261 ctttttcttt gcctgctgca agcgcgccga aaatggcaga tcctaaggct ggggcttgcg 2368321 gtgaaccaga gattttaatg tccatgtttg tcacatccgc ataaatctgc atgacaaacg 2368381 ggtttttctc agctattccg ccggctgcga acagttcctc aatcggaaca ccgctttctt 2368441 tgaatgtttc gataatcatc cgggttccgt aagctgtcgc ttcaactaac gctctataaa 2368501 tctcttcagg cttcgtcagc agtgtcatgc caagcagcat ccctgttaaa tctgcatcaa 2368561 caagagttga acggtttcca ttccaccaat ctaaagcaag caagccgctt tcaccaggcg 2368621 cttgatggtt tgctttctca ctcagcagct catgaacgcc aatgtttttt tcctttgctt 2368681 cctcttgata agctggcggg acacatgttt tcacaaacca gtcaaaatga tcgccgacac 2368741 aggactgccc ggcttcatat cccgcatagc ccgggagaat tccgttgtcc acaacgccgc 2368801 acattcctgg aacgatatgc acctcttcac caagtagaac atggcacgtc gaggttccca 2368861 taatcatcag cattttccct ggctctgtaa tgccgaccgc cggtaccgaa acatgagcgt 2368921 ccacattggc aaccgcaaca gccgttcccg ggagaagccc tgtcagcttt gccatttttt 2368981 cagtcagact gccggctttt tctcctactg aatgaataga acctgacaat ttgtcctttg 2369041 taatcgtttt cattgaagga tttaatttct caaagaaatc atctgacgga taccccgctt 2369101 tttcactcca catcgcttta taccctgcgg tacaattgct tcgcttgagc gagccgcaca 2369161 gctggtacac gatccagtcc gcagcctcga tgatccggtc agccgcttca taaatgtgag 2369221 gcgcttcctc ggcaatttgc atgacctttg gaatcatcca ttctgatgaa atttttcctc 2369281 cgtaccgctg taaaaaagcc tctccttctt cttccgcgat ttgattgagc cgatcagcat 2369341 gtttttgggc cgcatgatgc ttccagagct tcacatagct gtgcggctcc tcttcatatt 2369401 caggcagcat gcataacggc tgcccgctgc tgtcaatagg aaggatcgta catgccgtga 2369461 aatcaattcc aatcccgata atgtctttcg ggtcaacgcc cgtctgttcg agtaaagacg 2369521 gaatggttgt ttccaagact tcgaggtaat cagcagggtg ctgcagcgcc cagtcacgcg 2369581 gcagcttttg acccgttttt ggaaggacgg tatcaatgac agcatgcctg tattctttta 2369641 cagcagccgc aagttcctcc cctgtttgga catgaacgag cactgctctt cctgataaag 2369701 ttccaaaatc aacccctatt gtgtaagcca tgtgacatcc ccctctactt ttgaagccgg 2369761 taaagcgcct cgttccattt taactcgtgt ttcagtttat gaattgtcgt atcacgggaa 2369821 atgagaacac tttcgattcc cgccatttcc gcccaatcaa gcatttgctc cgctgtcagt 2369881 tcataagaca ggcaggtatg gtgtgcaccg ccggctaaaa tccatgcctc cgctgctgtt 2369941 ttcaatgacg gctccggctt ccagagaaca cgggcaaccg gtaaattcgg catgtctttt 2370001 tcaatttcct ggccgttgac ttcattcagc acaaggcgga aacgcccgcc aatatcaaca 2370061 atgctagctt gaatggcaga accgctgatg ccgttaaata ccaaacgcgc agggtcctct 2370121 ttgccgccaa tcgaaagcga atgaacctcg attttcggct gatccaaagc gacagtcgga 2370181 cacacttcaa gcatgtgaga gcccagaatc atttcatttc ccggttcaaa atggtacgtg 2370241 taatcttcca tgaaggaagt tctttttcct ttagccatga ttttcatcat ccgtacaagg 2370301 gccgctgtct tccaatctcc ttcaccggca aacccatagc ctttctccat caggcgctga 2370361 acggcaagtc ccggcagctg tttcattccg tgcagcactt caaacgatgt cgtaaacgct 2370421 gtgtatccgc cttgctcaag aaaagcggtt aatccaagtt caattttcgc ctgttcttta 2370481 atggacgcta cctttgcttc gtcacgtttt gtttcctcac tgatcacata tagtctgtca 2370541 tactcggcat aaagcgtgtc aacctcgtcg tccgtaatgc gatccatcac ttcaacgaga 2370601 tccccgatgc catatccgtc aacctgccag ccaaattgaa tatgcgctcc caccttgtct 2370661 ccgtccgtta ccgcgacatg acgcatgtta tctccaaatc tggcaacctt aatatgtctg 2370721 ctttcattta atgcagccgc cgtatccatc cactgggaca tttctttttt cacttcttca 2370781 tcatcccaat agccggcaat gacttttcgg ctaagcccca ttctcgagtt gatgtaaccg 2370841 tactctcgat cgccatgcgc ggattggttg ctgttcataa aatccatgtc aatcgtaccc 2370901 cacgggatat cgcgattata ttgggtatgc aaatgcataa gcggtttttg ataagaggaa 2370961 aggccttcta tccacatttt tgcaggggaa aatgtgtgca tccatgtaat gatgccagca 2371021 catgtctcac tgtactccgc ttctcttaac agctctctaa tggtttccgg tgaagtgacg 2371081 acgggcttat gagtgatttt atatctggaa gaaatcccgc tgagcccctc acaaatgctt 2371141 ttagcatgct gatctacgag ttccagcgtc tcttccccgt ataggtgctg gcttcctgtc 2371201 acaaaccaga attcataatc ctttgtctga agcatgtaaa ctgccccttt ctcataaaat 2371261 aaaacgcttt caaatacaaa agatacgtac taatgataga aaataaacct ataaataaat 2371321 atttgtacga acaattttat tatagtaatt gactattata ctgtcaatct tttcttttaa 2371381 aaaaagccgg gggcagagcc cggcttttta attcaatagg acggccagcc cgagctccaa 2371441 ttcaaatcat tgatgagaag ctttggaatg ccgttgtcat tggcatcata ggcatggcga 2371501 acaagaatgt ttccgttcac aatatcctgg cctccaggtc ctttccattg gtcattgccc 2371561 gaatccaaaa tggtgcctcc gccttcaagc atgctttttc cgcttttatc aagataaggg 2371621 cctgtaatgc ttttggatct tccgtaagca attttgtacg tactgtttac cccgtcacag 2371681 catttatcaa atgaaaccat taaatagtaa tatccatttt gatacgtaag agtaggagct 2371741 tctaaggcac ctccattatt cggtctagct gcaatcgaat agagcgagcc tgtaggcttc 2371801 attgtactct tatcgagctt agtcagctta atgccgctcc aaaacgagcc gaatgcaagc 2371861 cacgggttgc catccttatc gaatgtcagc tccggatcaa tggcgttata attatttgag 2371921 cttgtcgaac ggatcaccaa gccctcgtcc ttccagcccc ccgaactgat gcttgttgaa 2371981 gatgccaggc caatggcaga tgtattgctt ccaaaagaag aaacggaata atatagccag 2372041 tacttgccgt tatagtattg gatgtccggc gcccactggt tttggccata attcggcaca 2372101 taattggacc accacgatag cggtgtagtg aaaatggatt tttgtacggt ccaattttta 2372161 gcgtctgaag acttcaaaac ccgcagtccc cgttcttcag taagccctgt tccgagcgca 2372221 taccatgagc tcccctcttt aatcatagtc gggtcatgaa gcagctcatt ggatgcaccc 2372281 caaaacgctg cctctgcggg agcagcagaa gtgaatatca aacctgcagc cagagctgca 2372341 ctcgaaaagt gtaagaagcg tttccatgtt tttttctttt tcaattttgt tcaacctcct 2372401 ttattttaga aagcgcttac aaattagatt atttatcctc ccttcctgtc aaatcgactg 2372461 cgtatcgtat atcgtcatgt tcaggaaatt ttcggtatcc cctttattgt agtcactatg 2372521 ctgtaatttg tacagacaaa aaaatagaat ccacctcaat aggcggattc ttccgtatct 2372581 ttattggtac gtaatttcgt caaccgtttt tcggtctaac ttcttaatga cttctgtaat 2372641 taactttacc gcgttttcat aatcatcacg atgcagcatg gccgcgtgcg tatgaatgta 2372701 gcgggttgca atggtaatgg acagcgcagg aacgccattt gccgtcaaat ggatggcacc 2372761 cgaatcagtt ccgccgccgg caatggcatc aaattggtac ggaatgccgg cttcctccgc 2372821 agtggctaca actgcatcgc gcaaaccttt gtgagagacc atggatgcat cgtaaacgat 2372881 aatctgcggg cctttgccca ttttgctctg cgcttccttc tcggaaatgc caggcgtgtc 2372941 tcctgctatc cctacatcaa caccaaacgc aatatcaggc tgaatggtgt gtgcagccgt 2373001 tttcgctccc ctcagcccga cttcctcctg cacggttccg acgccataca ctatatttgg 2373061 atgatctgtg ttttgtaagt ttcttaacac atcaatagca atcgcacagc cgatgcggtt 2373121 gtcccaggcc tttgcgagta ggaatttttc attgttcatg accgtaaatt caaaatgcgg 2373181 aacgatcata tctcccggaa gtacacccca ctccaaggct tcttcccggc ttgaagctcc 2373241 aatatcaata aacatgtctt ttatttccac tgattttttt cttgcttcag gagacaaaat 2373301 atgaggcggc ttagatccga taacccctgt gatttctcct ttttttgtga caatggtgac 2373361 gcgctgagca agcataacct gagcccacca gccgccaacg gtttgaaaac ggataaagcc 2373421 tttatctgtg atttgtgtca ccataaagcc gacttcatcc aaatgtccgg cgatcataat 2373481 tttcgggccg ttttctgcac cagttttttt tgcaattaaa ctgcccaggc gatctgttgt 2373541 cacctcatca gcaaatggtt ctatgtatga tttcatcact tgccttactt ctctttcatt 2373601 gcccggtatg ccttttgcat ctgttaaatc tttcagcatg gtcaatgttt catctaattt 2373661 tgccatgttc caaaccctcc ttcatcagtc ctgcattctt attatacaaa acatggcgct 2373721 aaccatacga ctatttcact tgaaaatcgg gtatatgttt ttacagcttt cttttagaaa 2373781 aagtgaaacc tttttctatg cttttcgtat tacatcagat catcaccata agggaggtgc 2373841 cttcacacaa tgtttgtcat ggttctaagg attattttgc ttgcactttt tgcttattgt 2373901 atttatgccg tggtcaaata tgtcgcgaat cctaagagaa ggcttaagct ggcccaatca 2373961 aaagaacatt tttatattat tgatgaacaa aacaataccc ggaagaattt tcagctgacg 2374021 tataaaggcg tgctttttga gggagaaaag catattcctt ccaaggatca tccgctgttt 2374081 attcacacga tctttgtctg gacagaatct cctgagaagc tgaaacattt ctctgcaaaa 2374141 gattttgaga acattgaaga aaaagtgctg gaacgatatc caaattgtaa gattgactgg 2374201 gaccagccca ttaaactcgc aaaaaaagca gaagagcgtt aaacgctttt ctgcttttta 2374261 taaatcaaac gggctgtagt aaatagcgat gagaatcgct tctattacca gaagaagcgg 2374321 tactccgtac ttaaaagaag cgtgtttcgt tttatgtctg aaggtttgca tgccaagcca 2374381 gacaccgagc gctccaaaca cgatggctat cagccacagc cggtcttcag aaattctcca 2374441 cttgtgctgc tgcgctttgc gtttgtcaat gcccatcacc caaaaaccgc acagattaat 2374501 caacaccaaa taagcagcaa taatcatgtt gcctcatcct ttatatagaa aaagccgctc 2374561 tgctggagag cggctctata tgattacttg tttaattgag ctttagcagc atcagcaagc 2374621 tgattgaatg cagtaagatc gtttacagca agatcagcaa gcattttacg gtttacttcg 2374681 ataccagaaa gcttaagacc gtgcattaaa cggctgtaag aaaggccgtt catgcgagca 2374741 gctgcgttga tacgagtgat ccaaagttta cggaaatcac gttttttctg acgacggtca 2374801 cggaaagcat agtttccaga tttcatgacc tgctggttag ctactttgta taatgtatgt 2374861 tttgaaccga aataaccttt tgctaattta agaacctttt tacgacgctt acgtgtaaca 2374921 gttccgcctt ttactcttgg cattgaattt ccctcctaat tgttccttat ccgattactt 2374981 gatgttagca agcatttgtt tgatacgttt gaagtctcct gcgcttacaa cagcactctt 2375041 gcgaagctta cgcttttgct tttgagattt gttggcgaat aagtgacttg tgtacgcgtg 2375101 agaacgtttt aacttcccag aacctgtctt tttaaaacgt ttagcagatc cgcggtgagt 2375161 tttcattttt ggcatgggat ttcctcctta ttgcttttcg tttttcggtg cgagcattaa 2375221 gaacatgctg cggccgtcca tttttggttt tgtttcgact gtcgcaacct cagcacatgc 2375281 ttcggagaaa cggtctaata cacgctgacc gatttcttta tgagtgattg cgcgtccttt 2375341 aaagcggata gaagctttca ctttatcgcc tttttcaagg aatttaatcg cattgcgcaa 2375401 tttcgtgtta aagtcatgct catcgattgt cggacttaac cgaacttctt ttaagttaat 2375461 gattttttga ttcttgcgtg cttctttttc ctttttctgc tgctcaaatc ggaacttacc 2375521 gtagtccatg attcggcaga caggcggttt tgcattcgct gcaactaaca caaggtcaag 2375581 atttgcgcgg ccggcgattt caagtgcttc ctgacgggac ttgattccaa gctggtcgcc 2375641 attttgtccg attaaacgga cctcacgtgc acggataccc tcattaacca attgatcttt 2375701 gctaataatg agccacctcc atagtttctt cgaattgatt cacaactcat tttgaatgca 2375761 ttttgcaggc aaacaaaaag tgtgggcatt ataaaacacc cacactacga acatctgtat 2375821 caataaaaat gtacggtcaa cctgccaact acatgcatgt gtcaatcagg tgagaagcgg 2375881 gtgcttctgc ttgtgattta tattcaattc aataactatt ctacacaata ccggatcttt 2375941 agtcaaggac gacttatccg gaacaacttt tacattgtaa catgggtttt ctatgagcgc 2376001 aagagagaaa aagaaaatct ttcatcccca cccagaatac aaagaaccaa caattccccc 2376061 ttattacgca atttacaaca aaaccaccga caggaagaaa tgtaaaacaa agttaatctc 2376121 tgaccgatat aaggagcaga agggagcctg acacatgaac aaactgatac agcttgcttt 2376181 atttttcaca ttgatgttaa ccggttgctc gaatagcagc acatcttccg aatcaaaagt 2376241 cgaaaccact gttaagacaa cggcagcatt tcctcaaaag gagctggaga aagagctaaa 2376301 aaaactaaaa cccgtttcat tggacatgaa gttcgagagt ccactcgcta ccgagttagg 2376361 aaagcggaag gcaaaagagg aagctgaaaa gcaaagacaa atcgccgctg agaaaaagct 2376421 tgaaaaagag cgggaggcga aacgaaagaa acagcaggag gaaaaagcgg agagacagcg 2376481 attagcagag cagcaggctg cagagagaca gcgattagcc gaagcggaaa gacaagctga 2376541 acttgaaaga cagcggcagg cagcaatcca aaaagagcag aaagcgaacg ctgagaaaaa 2376601 gcggcaatcg caggcacaac ggcagcagac tgaggcaccc tcatctaata gtcaagatcc 2376661 accatcttcc tcgagtcaga cagataaaac cattcaacag ccagcttcag agcttcctga 2376721 tgacgatggt tatggttatg aagaacgaaa aaagtggcat gacgatcaag tagaatgggg 2376781 cattaaacaa gggtatatcg atcccgaaga cgcaccataa aataaaaaaa gccaaggcat 2376841 tcagccttgg cttatcctcc gatcagctgc acgaacacag ggatgaccag aaccgttacc 2376901 actcctacta cgacaacagc aatacttgcc atcgcagctt caacttctcc catctcaatc 2376961 ccgaccgcta caccaagtgc atgtccggat gttccaagag ccaatccttt agaaatcgga 2377021 tttttcactt taaacacctt caagaacaat gctccgagcg catatacgat gacagcgtta 2377081 aagatgaccg caaaggctgt gatgtcgctg atgcccccga tgccttttga taaaggaagc 2377141 gcaattgccg ttgtagccgc ctgcggaagc atgcttttca ttacggccga atcgagatga 2377201 atgcctttag cgagcagata aacaatcgtg acagagcaga tagagccggc aataatggag 2377261 gccatgattt gccaccagta ctttttaagc ttatctcttt gtttgtacaa aggaattgca 2377321 aatgcgatcg ttgccggttc aagaaaaaac ttaatgatct ctcccccgtt attataatcc 2377381 gcgtaggaaa aaccgccgat ttttaaaaat gcgatcccca gcaccatggc aacaaacaaa 2377441 ggagtgaaaa ggaagaagcc tttcgttttc ttaaataaaa aggtgccgat gccgaatgca 2377501 gcaagtgata cgacaatccc aaaataagga ctcattgtgc tttccatgtg aagaacctcc 2377561 tgtttccctt aatggtgaac gagttcgtta ttgttctgcg ggctttgcac tgtttttgtt 2377621 ttcatgtccg cttcggtttt gcgttttccg ctcagcgaca gaatcagctg agaaaacaat 2377681 cccgtagccc ccagcaaaat aatcgttgcg agcagaatga caagaacaat ttgcaggccg 2377741 tattgctgca tcacaccaag cgaattcata acagatatac ctgatggaac aaataaaaat 2377801 ccgatcagag aggttaaaga cgttccgagc gtctccactt gttccagttt aatgactttc 2377861 aaacataata ggagaaataa taagaccaac cctacaaccg atgccgggat aggtattggg 2377921 acaatagcgg caatcatatt tgaaaccagc ataatgacgg caaaaataaa tgcttgtgtt 2377981 aaaaacccgt acactttttt agcactcatt ttcttcacct ctttctcttt ggtaccctca 2378041 ttataaataa gaattccctg ttataaagcg cttacaagat aacatgccgt atagcgggtc 2378101 tgagttgcag aatcaaatgg ctgaaatgca aaaagccgcc catcaaatat ggagcagctt 2378161 tttcaattcc ttcgcatatg tccggctgac cggtattttc gatccgtctt tcatgatcag 2378221 attatacgtt gaattaaacc atggctgaat ttctttaata tattcagtat tcacgacaaa 2378281 gctccgatgg acgcggataa aatcagaatc cggcagcttt ttctcaatca caacgagtgt 2378341 atcgctgacc gtataagaat gatcgaaggt ttttacattg acatgaccat cttctgttcc 2378401 ggcatagata atgtccttcg tatccacaat cacaatcgat tcccccacag atagcgcgag 2378461 cttgtgctgg ccggcatggc tgttttgctc tgtttctaca atatcccgat tgactttttt 2378521 atattttttc agcgtttgct gaattctttc ttcatcgaaa ggcttggtta aataatcaag 2378581 agcgtccacc tcaaacgctt tgagcgcata ctggtcatac gctgtcgcaa acacaatagc 2378641 aggaggatgc ttcattttct tcaatcgctt tgcgatatca aaaccgtttt ctccggataa 2378701 atcaacgtct aaaaacagca aatcaggttt ttgatccatc atttggtcaa aagcggattc 2378761 gatattttcc gcttcattga tttccatttc atcattggtc cgcttaagca agtaagccag 2378821 ttcatccctt gccagcatct catcatcaac tattaacacc ctgagcatgt tcttctccct 2378881 ctttcatctg ttgcattggc acttgaaagg aaacctctgt ccctttatga acctcactgc 2378941 tgatatgcag tgcagcctgc tgtccgaata aaccgatcag ccgctgattt aggttataaa 2379001 gcgctgtacc ggttccctcc ttagacggaa acggtttctt ccccagttcc ggcaagacgt 2379061 ccggcggaat tccgcgtccg ttatccgcca ccttcatata gacggatgca tcatcagata 2379121 agacacagac tgtaaccttg catatgtctt gttttttcgg aaacgcgtgc cgaagcgcgt 2379181 tctcgacaag cacctgcaaa acaaacggag ggatttcaat ctgctccagt ctgctgtcga 2379241 tattaagctc aattttatat ttcccgggaa aacgcgcctg ttctaatgac aaataggcgt 2379301 taagatggtt cagctccttt gagagcggaa tcagcagctg tctcgctcct tgaaggtttg 2379361 aacgaaaata aacactgagc tgcaatagga gcttacgggt tttttcaaca tctgtacggc 2379421 ataacgcaga aatcgtgttg atcgcattaa ataaaaaatg cggattcacc tgtgcttgaa 2379481 gcgctttaat ttcagcatcc ttgagaagtt tgctttgcag ctctgcttcc ccaagctcaa 2379541 gctgtgtcga aaacagcatg gccagcccct cggcaagttc ctcctctacc tgactcaggc 2379601 ctgccgggct tttaaagtac atttttaagg tgccgattgt attgccgttc gatgtcagcg 2379661 gtaggacaat tgcagcgtgc aaagggcatt cagcatgcgt gcattcaatc tcttcctgcg 2379721 aaatcgcctt cataatatgc cctgttttaa tcaccttttt ggacaggccg gtgatcaagc 2379781 ttttcgatgg gatgtggtga tccattcccg caccgacatg cgcaaggatc ttttctttgt 2379841 cagtgagaga caccgcatct gttcctgtca gcttatggat aatagccgct acacttttac 2379901 aggagttttc atttaatcct tggcggaaaa atggaagtgt ctgatcagca atcgtaagca 2379961 ctcgatgcgt ttcgagagcc cttgcctgtt cttccttgcg aatgatcgct tgaataatag 2380021 acagaaaaat aaaactgcct gttccattga tgagtatcat cggaattccg atcatgctga 2380081 caagctccca agcgtcactg aacggctttg ccatcagcaa aataatgatc atttgcagtg 2380141 actccatgcc gattcccaca agagcggcga tgcgcggtgt cggcattcga tatcgcttcg 2380201 taaaatacct gccgatcaag cctgcaagaa cacccgctaa aatagatgag acggcacagc 2380261 ttaaggccgt gctgccaccg agtgaaaaac gatgcaggcc cgcaagtatg ccgatcccag 2380321 cccctacaaa aggacctccg agaaggcccc cgatttccac gcccaaaata cgggtattcg 2380381 cgatagagcc cgatggatct atcgtaaaca cccagtcatt gtttacaatc atatttcttt 2380441 gaatttcgat gcctgtataa ttgctgatga tgctgaaaag agaaaaaata gaaattaaaa 2380501 tcgcttttcc tttatagccg tcctgattct gaagagcttg tctgaaaagt ttcgtatggg 2380561 cgagaatgaa ccctaatata acaataatcc ccactctctc cagcatcata atcattaaat 2380621 gaatcattca tgtcacctgt tctttccgtt ttcattctag catgttttcg ttttgcggct 2380681 gactgttttt ttaaaatcgt ctgaaaacat atttcacaag gcttttatct attgtaaaat 2380741 aaaacatgag ccttttggca gaaagatttg aatctgaagc agaggagaag atcatgaaag 2380801 ccgtattttt tgatttagat gatacactac tttgggacga aaaaagcgtc agaacaacat 2380861 ttgcagaaac ttgcttacag gcggagaaaa aatatggcct tgcccctgag gaattcgaag 2380921 cagctgttcg cgaagcggcg agagaattgt acatgtcata tgagacgtat ccatatacag 2380981 tgatgatcgg cattaacccg tttgaaggac tgtggtccaa tttctcagag ccaatcagtg 2381041 aaggctttca aaagctgaac aagattgtgc cggagtacag aagaaatgca tggaccaacg 2381101 gactgaaagc gcttgggatc gatgatcctg catatggcga atacttggga gagttttttg 2381161 cggcagagcg cagaaagcgc ccgtttgtat atgatgaaac ttttgctgta ctcgatcaat 2381221 taaaaggcaa gtatgaatta ttgcttttga caaatggcga tcctagtctg caaaaggaga 2381281 agcttgccgg cgtgcctgag ctcgctcctt acttcaatga aatcgtcatc tcgggcgcat 2381341 tcggcaaggg caagccggat gtttcaattt ttgaacactg ccttaagctg atgaatattg 2381401 aaaaagacga tgccatcatg gtcggcgata atttgaatac tgatatttta ggcgcttcaa 2381461 gagccggaat caaaaccgtt tggatcaacc ggactgataa gaaaaacgaa actgacgtaa 2381521 agcctgatta catcatcagc agccttcatg atttgtttcc tatattagag aaataaaaaa 2381581 agcatgatct cttcaatgag atcatgcttt tttattttat tttttcgctt cagctactgc 2381641 ctttttcaca aactcatcaa gtgaaatggt ttcagagttc tgttctccgt atttacgcac 2381701 gtttaccgct ccgttttctg cttcttggtc accgaccacc agcatgtacg ggattttttg 2381761 catttgcgct tcacggattt tgtagccgat tttttcatcg cggctgtcga cttcaacacg 2381821 caggccttca cattgcaggc gttcctgcac ttttttcgcg tagtctaaat gcacagccgg 2381881 agaaaccggg atgacttgga actgaaccgg tgcaagccat gtcggcagcg cgcctttgtg 2381941 ttcttcgatt aagaaagcaa caaagcgttc cattgttgaa acgacacctc tgtgaatgac 2382001 aaccggacgg tgctgcttgc cgtcctcacc gatgtatgtc aggtcgaaac gttccggcaa 2382061 taagaaatca agctgaaccg tagacagtgt ttcttctttt ccgatcgcag ttttcacctg 2382121 aacatcaagt ttaggtccgt agaatgccgc ttcaccttct gcttcgtaat agtcgtggcc 2382181 gatttcatcc attgcctctt tcagcatgga ttgcgctttg ttccacattt catcgtcatc 2382241 aaaatatttc tctgtatctt ccggatcgcg gtaagacaga cggaatgtgt aatcacttaa 2382301 accgaagtct tcataaacat cctggattaa acggactgta cggataaact catccttaat 2382361 ttgatccggg cgcacaaaga tgtgtgcatc atttaacgtc attccgcgta cccgttgaag 2382421 tcctgacagc gcacctgaca tttcatagcg gtgcatcgtt ccaagctctg caatacgaat 2382481 cggaagctcg cggtaactgt gaatgtcttg tttgtaaatc atcatatggt gcggacagtt 2382541 catcggacgc aatacaagtg tttcattgtc catttccatc ggagggaaca tgccttcctg 2382601 ataatgatcc cagtgtcctg atgtttcata cagctctttg ctgcctagca caggtgtgta 2382661 tacgtgctca tagccgaggc tgatttcttt atcgacaatg tagcgctcga tgacgcggcg 2382721 gattgttgcg ccttttggca gccaaagcgg caggccttgt ccgacttttt gagagttcgc 2382781 gaacagcttt aattctttgc caagctttct gtggtcgcgt tctttcgctt cttctagcat 2382841 acgaagatgc tcttcaagat cagctttttt gaagaaagct gtaccatata cgcgctgaag 2382901 catttggttt ttgctgtcac cgcgccagta tgcgcctgca aggcttaaca gcttaaattc 2382961 tttgattttt ccggttgaag gaacatggac gccgcggcac aggtcaaaga attcgccttg 2383021 ctcatagatc gaaacggttt ctccttcagg aatcgcatcc aatagttcaa gcttcaggtc 2383081 gtcgccgatt tccgcaaaac gggctttcgc ttcttcacgg ctgacttctt ttcgaacgat 2383141 cggaaggttc gcattaacga tttttttcat ttctttctcg attttcggca gatcctccgg 2383201 tgtaatcgct tcgtccattt ctacatcgta gtaaaaaccg ttttcgataa ccggaccgac 2383261 gccgaattta acatccttgt agatgcgttt aatcgcttga gccagcaagt gagccgcact 2383321 gtggcgcata atttgaagac cttcttctga gccttctgta atgatttcca ctgtaccgtc 2383381 ttcattgatc ggcgttctca aatcgatttc ttttccgttc agttttccgg ctaatgactt 2383441 tttctttaat cccggactga tggatgccgc gatatcttct gttgttgttc ctttcgcaaa 2383501 ctccttgact gctccatcag gaaatgtgat ttttaccata tctgacatct ttgtcactcc 2383561 tttttttgca tataaaaacc ccgcccccta tgaaagggac gaggttgaat aaacggaatc 2383621 gtggttccac ccttttttcc gcaaagccaa tacacggcac ctgcggctct aagctctgta 2383681 acgggagttc ccgtcagcca ttactgttcc ttttcaagag gttcacagct gaagttcaaa 2383741 ggcggtaaag cgaatggtcc ttagctggga agcttgcagc cagggcttcc ctctctttga 2383801 gccggtatca ttccttcgtg tccttatcaa tacgtgtgtc tttcttaatc tcctatgtat 2383861 tataaattgt tcaatccaaa aaatcaacac gatcgcgttt cctttttttt aaaccgacag 2383921 ccttaaatag acaggctgcc ggccctcatc cttccgagtg cttcaccggt atttctgcat 2383981 ctgtaaaagc atgcagcggg agcatttcca ctctctcttg aaatacgttt tgaatggtcc 2384041 ttgccatcat gtgctcgggc tggtcggtat aaagcacgac ttcatcaggc gcaatggaaa 2384101 tcagcggcgc gagcaaatga gaatcaatat acataggatg atcccggaca aatcttctgt 2384161 ctatgtattt cattttttcc cgttccggca catagcgcag ctcccataat gtaaaggaac 2384221 catcatggac aatatgcact tttttgattc gcggctgttt ggcgtccaca tagtctctga 2384281 gtgtttgaat aaagttttga tattcctgtt ccatcttata ttcatcaatc gctgcttctg 2384341 taatatctct cagctgctta tagtatgatc caagtcggaa ggtctgaaag gagcgaatgt 2384401 aaaatactcc ttcctctaaa cagatcgttt ggagttcatc caaaattgat tgtttccgtg 2384461 aaagcttcag cggctcaaac ggaagatcgt ctgcttcacc ttcaataata ctgtgtgcga 2384521 gctgaaggat ttgctgctgt tcatcctggt ccgtgaaaca atacgtttcc tcaatcaatg 2384581 acagcatatg ctcgtcttct ttgcattcca aaaaaaattt gaccagaatc ggctccataa 2384641 aacgctgaat aggaaaagcc ggattcgctt tttcaatccc gatttttcgt atgccttcac 2384701 ggacaatgat attgttccga tcgtccgaat gctgaatgag atgtaaaaaa gcggctgcat 2384761 catggtcatc ttcaaagatt atttcaagca tgtttgtccc cccttacggc atctgttaca 2384821 agtatatggg ggatgttttt aaaatagacg taaaggtcat tggcaaatct taatttgatt 2384881 cttggaacaa gttttgcatt ttctttctga agatgaacgg caatgagata aacacgatat 2384941 acaaagcgag caccataaag aaagcgggca gattgccagc caaaaagctc gcacccagca 2385001 cattaagcgc aatcgtccca gggatgattc ccacagccgt tgcggcaaaa tacggcagcg 2385061 ctttgacatt ggaaaggcct gccgcatagc tgacgaaatc aaaattgatc ggcaggattc 2385121 tcaaaagaaa gatatagaaa aatccgttat cctccatttg cttctgtatg gcttcaagcc 2385181 tttcgtaatg cccgttcttt ttcgccgaaa acaaaccagc cgcaaaaaac gaaacagctg 2385241 aagcgcacat cgaaccgaat aacgtataaa gcgtgccgag aagcgggcca aacgcaagtc 2385301 cgccagctat tgaaataaca gacaccggaa ataaaacaag tggcctgacg atggatatcc 2385361 cgataaacat cagaggtgca aagactccga acgacaatac ccataccctg atttctttcg 2385421 gcgatacatt caaatacgtt ttatttcccc aatagagtaa accagcacct gcaagcactg 2385481 ccagccattt gacagccgtt tttcgtttca taccctcagt tccttcccct ttgaaccaca 2385541 gcaattatgg atgtcggcgg ttttctccgt caaggcggat cggagcagcc aaatataata 2385601 tccgctccat taatcttgca gcttttactt cttctttttc tcccctctgc gaatacgtaa 2385661 aatgatgctt cagctcgtca ggtgagaaat tagaagaaaa gaacgttggc agctgctggg 2385721 acattctgtg ctgaagcacc gttccgatga cctcatccct tacccagctt gtcattgatt 2385781 ctgctccgat gtcatcaagc attaatacgg gtgtggtctt taccatattg agcttctctt 2385841 ccaatgtctg gtcttgcagc gaattcttaa gctctctcac aaattcaggc acataaacaa 2385901 tcatggagga atactctttt tccgccagct cattggcaat tgcagcgagc ataaacgttt 2385961 ttcctacccc aaatttcccg tataaatata atcctttccc ttttcccgtc tcattatagc 2386021 ttttcaggaa gtctgtaaca tgctgaaaca tcgcgagtct gcttgggtca ctgatatcaa 2386081 cttgctggaa cgtcgctcca agaagatcct gctggatata catgcttttc ataagagact 2386141 gttgtttctt ctgctggtcg agcttccgtt tgactggaca ttcgtaatac tcgatatcaa 2386201 tagacctccc attgacaaca agcttcggat ggtagccctc caacaaattg ttgcagtttt 2386261 catcttccga acaataggag caattcttgc tttgttcgat atattcataa agcttattta 2386321 agctcttttc gatcattttt tggtcaatca cttcttcgtt ttccttcaaa aatgcttgaa 2386381 catcttgatc tttcatgact ttttccttca tttgttcaag acgtttttgg aaatccggcc 2386441 tgccggttac gccctgcagg gaacggccga ttggttccat ctattccttc accccgcatc 2386501 tctgtcttta ataggcagag tattttttca gtttttgcat ttcttccatc atctttttct 2386561 tctgttcttc caaatcctgc ggatgcagct tctgctgtcc ggattctgaa tcggacgctg 2386621 tttccttttc tgtcatccaa tcaggaagct tttcttcacg aatcactttt tggtttcgtt 2386681 tcgaagactt tgtttttccc tcagcccatt caagatactg gcggttttct tctattgcga 2386741 gcttcatcgc ttccctgacc gttttcacct ttttgcgtgc ccaatgcgaa gcgatttttt 2386801 ggatatagtt tttcgacagc ttcatgtcgg ttttcagcat gacataataa attaacacat 2386861 ttgtgacgcc tggctcgagc ttctgttcga acataatttc ttctatgatc ttcagatcag 2386921 cttttgacgg ctctgttccg tcagcaatgt cctgcagaag cttcttcggg gaaatcgcct 2386981 ccagcaatgc aatcagcttc ccatccagag aatcctcttc tgccggttgt tcgccttcac 2387041 gcagatgcac cggctgtgtt ttttccacca aatcgggcag ctgtccgttt ctttcaattt 2387101 gataccagtc gctcgccgct tttcttaatg cctccgtcgt aatgacgtca cgctcatcaa 2387161 ttgcgctcat cacaacattt tgcatttgca aagggtcaat tccgtacaga taagaaagct 2387221 ttttgattgt gtcccgcacc tgctgggtca tcgcttttct cggtatcatc gtctcagaaa 2387281 gtcccgctaa aaacaaatca aaatcaaaca catcctccgt tatggtgtag gacggagact 2387341 gtccgacaga agtatactcg gacccctcgg caagccttac cgtttcctcc atatcggatg 2387401 tgagcttcca ttcactcggc tgcagcgatt caaacgcatg attaaacgga cgcgtaatgt 2387461 ccttcgcatc ttctgaaatg gccgggtgcg taaaaaattg ttttaattgc tgatatttcg 2387521 tttttccgac cctattatac agaaaaacat tcagcattcc gtcttcaaaa aattcatttg 2387581 gtctgagcgg cggaaggagt tcatatataa agaggcgctc ctgccgctcg gattctttca 2387641 tatatacttt cagcaatccg atgccctcga gcttcccctg ttcctgatgg atcgttttta 2387701 agttggactg tgtcatcccc atcagctgtc tatgtgtgga ctctccgccc cacagacggt 2387761 tttgttcaag ctctccccac aatgtcatat aaagagagaa tgcaacaggg ccgattaagg 2387821 gctggtacag ttgtgtaata atttgtctgt caatatcctg cagcatcgat ctgcttttaa 2387881 ccacatacgg gtctacaggc agtacatctt tccaatagtc agccatacat tctcaaacct 2387941 tccgaatttg tttctacctt tcattttaca ccgtttctta tatctatcaa atgccaattt 2388001 tgcacatgag aaaagagcta gaagaatcct cttagctctt ttaacgctct ttctttatta 2388061 agtcttttaa ttcatcgata aagacgttta tatctttaaa ctgccgatag acggacgcga 2388121 accgcacata tgcgacttcg tcaatcttag ccagccggtc catgaccatt tctccgacga 2388181 gctcactctt cacctcggag cagccttgat tgcgaagttc tttttcaata tcaaagcaca 2388241 tgtcttcaag cgttttgagt gaaacaggcc ttttttcaca tgcttttatg aggccgcgca 2388301 gcattttttc tctgctgaat tcctcacgca caccttcttt tttcacaacg atgagcgggg 2388361 tttcctccac tttctcaaag gtcgtaaacc ggtagtggca ggattcgcac tcgcgtcttc 2388421 ggcgaatcga ctttccgtca tccacaggcc gtgaatcaag gactcgtgtt ccgttatgct 2388481 ggcatgaagg acatttcaat aaaatcagct cccaactata tcgttccctg caatgtattt 2388541 tcggcagcct ccgcctttta aaaatagatg tgacagcatc tgtcgggaga gccgttgtta 2388601 aatttgtttc tatagcatta ggtggtttgt gaaaatctcc ttcttatttt acaaaaaaaa 2388661 tgaaaaaaga aaaagctgac actctcgttt ctttataaaa ataaaaggag cataagctaa 2388721 aaagcgcata atggctttct agcttcagct ccctttgtgt tcgcaattta ctttatagta 2388781 ctttcgcttg cgcctgttta atttgcacag gccccattcc tcttggtatt tcaatgtttt 2388841 ctcttgtatc agcatgtaat gcctctgcaa tgtaatcagc agcgacatta ggatctaagt 2388901 ctccacaagt ataaacatca atgctcgcat atccgtgctc aggaaaactg tgaatcgtta 2388961 agtgtgattc agaaataatc acaactccgc ttacgccttg cggtgcaaat ttgtgaaatg 2389021 caacctcgcg cacctcagca cctgatttta gagcagcatt tacaaacgtt ttttcaataa 2389081 aatccatgtc attcagctta tcaaaatcgc atccccatag ctcggagata acgtgacgcc 2389141 ccattgtttc catagtcatg gacccccctt aacaagaatt aaaaagtgaa attccaacaa 2389201 ctgggtcggc catttaccac gggggaaagt tagtccggag aggtcctaac cctttaagta 2389261 attccgaaac agtctcaagc aagaagttca cgaaaaatag tatactgtgt ttaagtctaa 2389321 tttgcaaggt gcgttttttc agaaatatgc tgttaagggt tttttcttta aaatgtgtcc 2389381 atgaccttat tttatacagc agacggatgt ttcattcgtg ccgctacatg gcggattaga 2389441 tcaacaactc tgcaggagta gccccattcg ttgtcatacc acgccagcac ctttactttc 2389501 ctgtcttcca ttaccattgt tgtaagcccg tcaatgaccg ctgaatgcgg attcgtatta 2389561 taatcagtcg aaacgagcgg ttcatctgag taatcaagta caccgtacat cgacgttttg 2389621 gcagcgcgtt taaatgcctc gtttacttct tcagccgtaa catccgtttt cagatcaaca 2389681 acgagatcaa ccaatgagac gttcggaaca gggacacgca aggcgaggcc gtgaagtttt 2389741 cctttcagat gcggcagcac aagcgaaagc gcctttgccg ctcctgttgt tgttggaatg 2389801 atggattcac cgcaagcccg cgcccggcgc aaatctttgt gcgggttatc aatatttttt 2389861 tggtcattcg tatacgcatg aactgtagtc atcagaccgc tctcaatgcc aaactcttca 2389921 tccagcactt ttacaacagg cgcaaggcaa tttgtcgtgc atgacgcatt tgaaataatg 2389981 acatggcgct cagcgtcgaa ttggtcctca tttacgccca tcacaatggt aacgtcttca 2390041 ttttttcccg gagcggtcaa aatcactttt tttgcacctg cttctatatg gcccatcgct 2390101 ttatctttag cattaaactt ccctgttgct tcgacgacta tgtcaatatc atattcccgc 2390161 caaggcagct gttttggatc acggctgttt aacaaaagca ctttctttcc atttacgatc 2390221 aggctatctt caccagccac aacctctttg tcgtatctgc cgtgaattgt gtcatacttt 2390281 attaaatgag ccagcgtttc tgcggaatag ctggcgttaa tggccactac ttgaatttga 2390341 tcgtctaaca tcgcttttct aaaaaccatt cttccgattc ttccaaaccc gttgatcgct 2390401 acttttacct tcatgttgga caccccttat caattatgcc atcctaattt gttactatct 2390461 aaaattagta taacacatta aaacaaattc gccagtacat attgataaaa atcaacgatt 2390521 ataacgctaa tttatgatgc atcttatgtt ttcttgcaca gaatatcagg cgtaagaacc 2390581 aaaaagcagc cagcgctccg cactgactgc cctcatgctt tatgattcct gttttaactt 2390641 atcattgagc acactttctt ctagcacaga aaatgtatcc ccgtacactc tgttaatatg 2390701 attcgctccc caagcacaca gcatatctaa aatcccttct aagctgcggc cgtattcgct 2390761 gagctcgtat tccactttgg gaggaacttg attatatacg attcggttaa tgacaccgtc 2390821 cgcttccagc tcgcgcagct gctgagtcag cattttttgc gtgatattgg gcattaggcg 2390881 ttttaattca cttgtgcgtt tttttccgtg cgtcagatgg cataaaatga cgcatttcca 2390941 tttcccaccg atcacttcaa gagtcgcttc aacagaaatg ttatattttt tcttctccat 2391001 acaatccatt ctcctcacag gcaccaaaaa gtgactatag cacttcaaag tacgtacttt 2391061 tatttcttaa cgatatgttt cataatcaca tttgccggct gatttgaatc tgctcttttt 2391121 tatttatata gcttactcgg cagaatttca atcatacaac acatcttaca aaggaggaac 2391181 atcatgactt cagccaataa aagcaatatt cctgcactac tggctttggc cgtaagtgca 2391241 ttcgcaatag ggacaactga atttatcagt gtcggccttt tgccgctcat tgctgatgac 2391301 ctggatattc ccgtcacgac agcaggattg accgtttccc tttatgcgct cggcgttaca 2391361 tttggggcac ctatattaac ttcattgacc tcaagcatgt cacgtaagac actattgctt 2391421 tggatcatgt ttatttttat tgccggtaat acgatggcag caaccgcttc aagcatcggg 2391481 attttactag cagcacgtgt gatatcggca ttttcgcacg gtgtgtttat gtcgatcggt 2391541 tcgacaatcg cagcggatat tgtcccggag gataaaaggg ctagcgcgat ttcaattatg 2391601 tttactggcc tcactgtggc aactgtaacc ggagttcctt ttgggacatt tatcggccag 2391661 cagttcggct ggcgtttcgc ctttatggtc attatcgccg tcggaatcat tgctttcatt 2391721 acaaatggca ttcttgtacc gtccaaatta cgaaaaggga cgaaaacaac gatgcgggat 2391781 caattgaagc ttgtgacaaa cagccggtta ttgcttttat ttgtcattac agcgcttgga 2391841 tacggaggaa cattcgttgt gttcacgtat ctgtctcccc tgcttcagga agtaacaggc 2391901 ttcaaagccg ggactgttgc agtgattctg ctcggatacg gaatagctat tgctatcggc 2391961 aatatgattg gcggaaagct gtcaaaccga aatccgattg ccgctttatt ctatatgttt 2392021 atcgtacagg caatcgttct attcgtactg acatttacag ccccgtatca agcagcaggg 2392081 ctcattacca ttctctgtat gggattgctg gcctttatga acgtgcccgg ccttcaggtg 2392141 tatgtcgtca tgctggctga gcgttttgtc ccgagtgcag ttgacgtcgc atccgcgatg 2392201 aatatcgctg cctttaatgc agggatcgcg cttgggtcat accttggcgg tgtgatcacc 2392261 gattcaatcg gattgattca taccgcttgg ataggcggat taatggtggt cggtgcagtc 2392321 attttaacag gctggagccg cttgatggaa aaacgagatc ggcaggaagc ctgacaattt 2392381 taaaggagga aataaacatg acaacacatt tacaagcaaa agcaacactt cataatgggg 2392441 tagaaatgcc ttggttcggc ctcggcgtgt tccaagtgga agaaggatct gaactggtaa 2392501 acgcagttaa aactgccatt gttcacgggt accgcagtat tgatactgca gcaatctatg 2392561 gaaatgaagc tggagtcgga gaagggattc gggaaggcat tgaagaagca ggcatttcaa 2392621 gagaggatct gtttatcaca tcgaaagtat ggaatgcgga tttaggctac gaagaaacac 2392681 tcgccgcgtt tgaaacaagt ctgtccaaac tcggtctgga ttatttggat ctatacctca 2392741 tccactggcc tgtagaagga aagtataaag aagcttggag agcgcttgaa acgctgtata 2392801 aagaaggccg tatcaaagcg attggcgtaa gcaacttcca aattcaccat cttgaagatc 2392861 tgatgacggc agctgaaatt aagcctatga ttaaccaagt ggaatttcac ccgcgcctca 2392921 cacaaaaaga gttgataaga tactgccaaa atcagggcat ccagatggag gcttggtcac 2392981 ctttaatgca gggacagctg ctggatcacc ctgtattggc tgacatcgct caaacatata 2393041 ataaatctgt cgcacaaatt attttgcgct gggatctgca gcatggcatt ataacgattc 2393101 ctaaatcaac gaaggaacac cgcattaaag aaaatgcaag cgtatttgac tttgaattaa 2393161 cgcaggatga catgaaccga atcgatgcac tgaatgaaaa cttgcgcgtc ggtcctgatc 2393221 cggacaactt tgatttttaa tggccaaaaa acaccgttca atatgaacgg tgttttttgt 2393281 attatgccca gctgttcatg atttcatcaa gctgcctttt ggtctcttca agcgtgccgc 2393341 tgttatcaat gacttgatct gctcttgctg ttttttcctc taagggcatt tgagagcgga 2393401 tacggctgac tgcttcttct tctgtcagct gattgcgctt catcagacgt tccagttgaa 2393461 gctcttttgt cacactgacc acaataattt tatcaaccaa tgattccaat ttgctttcga 2393521 acaatagcgg gatatccaat acaacaaatg cctcccgatt tgcaacggct tcatcacggc 2393581 gattgagcat ttcctgcctg actgcgggat gaacaattgc atttaaagcg agacgttttt 2393641 gttcatttgt aaataccagc gctccaagct tttttctatc tatatcgcca tttgagagca 2393701 gtatgtcttc accgaattcg tcaatgattt gccggtaggc cggcatccct ttttctaccg 2393761 cttgttttgc aatgatatct gcatctataa ctgttattcc tttttcaatc agcatattgg 2393821 ctaccgtgct tttgccgcta gctattcctc ccgttaaacc aatgactaag gtcaagagat 2393881 ccactccttt ttacaatttc cagagcccaa tcgtgattaa tagaagcccc ggcaaaaacg 2393941 ccattttatc gatccatttc cacttagaca gaaaatggcc ggcattgatt ccaattgata 2394001 caaacagcga gctcatgatt gccacggcga tgctcatcac aatcggcgaa aaaccgagaa 2394061 tggctgcgcc tatacctgct ccaaaggcat caatcgataa ggcaaatccc aataagaccg 2394121 cctcaattcc gttgatcaca cccgatttgt cgatatccgc actcatgggt tttctcaaaa 2394181 tatgaatcac aattcctaat gaccgaacct ctagattaag cagtgttttt tcatgcaata 2394241 ggtattcttt atcttttgcc ggtttgaaaa attgatacag aacccacgca ccgattccaa 2394301 ccaatatcaa accgccaagc ttctccgtca catatacagg aaaaaacttc gtgagaaagc 2394361 ttccgatcag catggatata aacatgacag caccggaaca gcaggcgata accaaaatcg 2394421 ctttaaacgg tattttcatt tttctcaatc cgtacgtaaa tccgactgaa aaactgtcca 2394481 agctgacagc caacgccagc agcagtatag aaaccatttg catatccgtt tcttcctttc 2394541 tgttggtgct cttgtatcag atgtgaaatg cccgggattc atcacaatca tatatatggg 2394601 aaagtgaaaa atccgtgttt cgaaaatggc atccttaatc cagagttact gatatatgca 2394661 ccgacagctt ggacaatgaa gcattatgct acttttttgt ctggcacttt gcgcaaaaat 2394721 gcgtgcctct tcctccaacg acaattttcg aaatcatcgt tccgcaattt ttgcatggct 2394781 cgtctttttt tccgtacaca aaatgctgca gctggaacat tccgatttcc ccttgggagt 2394841 tgatatatga acggactgtg cttccgcccg catcaatcgc ctcctgcaga gtgtttttga 2394901 tttcagcgtg aagggttttg attgttttat ctgataattg atttgctttt gtctcgggat 2394961 ggacacccgc tctgaaaaga gcctcatcca cataaatgtt cccgagtcca actaccgttt 2395021 tttgatccag tagggcagtt ttgacagcgc ggtttgtttt cgcaagccgg tcttttaaat 2395081 acgcacttgt aaattcttct gcatccggct ccggccctaa ctgagaaagc gggagctcgc 2395141 ccgcttcttc tcccggttta aataagtgca tggttccaaa tttccgcaca tccctgtacc 2395201 ggagctgggt tccatccgtc atcgtgaata tgacatgcac gtgtttatcg tcaggctcct 2395261 cggcttgatg aagaccgtat tttccttcca ttcgaaggtg agaaaccata acataatgat 2395321 ctaaatgaaa cagtaaaaac tttccccgtc ttccgatgga ctgtatcgtt tctcctgcta 2395381 gttttcgcgc aaattcctcc ggttcggcag gccgtttgat gatattcggc catctgatct 2395441 ctaccgattt gattgttttt ccctttacaa gcccggtcag agtgcgccgg accgtctcaa 2395501 cctctggtaa ttccggcaca tccatcactt cctatctctg tttatttcgc atcgtaccaa 2395561 gatgggcctg atgcaaagtc cacctttaac ggcacatcta atgcaagcgc atgctccatc 2395621 acttcaggaa caagcttttc aagaatttca atttcttcct ttggcgcctc aaaaatcaat 2395681 tcatcgtgta cttgaagcag aagccttgct ttcaactgtt tttctttcag cttggcagcc 2395741 atgtcaatca tggctttttt gataatatca gcggcgcttc cttgaatcgg cgtattcatg 2395801 gccgtccgct ccgcaaaact tcggatatta aagttccggc tcgtcagctc agggatgtag 2395861 cggcggcgat gcataagcgt tgttacgtat cctttttgtt tcgcttcctg tactgaatct 2395921 tccatgtacg cttttacgcc ttggaagctt tccagatagc ggtcgataaa tgctcccgct 2395981 tccttccggg taatgccgag gttctgtgac agaccgtaat cgctgatccc gtaaacaatg 2396041 ccaaagttga ccgctttcgc ctggcgtctc atcgcagatg tcacttcatc cttagcgaca 2396101 tggaacacat ccattgccgt tttcgtgtga atatccatat cattagtaaa agcttcgatc 2396161 agattttcat cctttgaaat atgggcaagc acccgcagct cgatttgtga ataatcggct 2396221 gcaaaaatga gccagtcttt ttcagacggc acaaaagctt ggcgaatttt ccgcccttcc 2396281 tcaagcctga tcggaatgtt ttgcaggttc ggatcagtcg agctgagacg gccagtttgc 2396341 gttaaggcct ggttaaatcg cgtgtgcact ttatgcgaat ccggtctcgt cacctttaaa 2396401 agcccttcga tatatgttga ttgaagcttg ccaatttgtc tgtactgtaa aatatagtcg 2396461 acaatatcat gcttgtcagc cagcttttca agcacatcgg cagacgtaga atagcctgtt 2396521 ttcgttttct ttacgacagg aaggccgatc ttttcaaata agatgacgcc tagctgtttc 2396581 ggagaattga tgttaaacgg ctctcccgca atctcatgga ttttttcttc atattccttc 2396641 agcttcgcac ccagttcttc acccatccgt tttaaacggt caacatcgac cttgacgcca 2396701 gttgattcca tttcgccaag aataagcgca agaggcattt ccagctcttc aaacagttca 2396761 agctggtcgt tgttttccag ctcttgaacg agcttttccc gaaggctttg aatcgctaac 2396821 gcttttcggc caaggtgctc agacagtacg tcttctgacg gcactgcccg ttttgctcct 2396881 tttccataaa ctgattcatc acttgaaacg atatgcaggc cgtaatcctt agccacactc 2396941 gcaacgtcgt catatgaatt gcccgggttg atgatataag ccgcaaggag cgtatcaaac 2397001 tcggctcctt tcagctcaat gccctgccag cgcaaagcga caacggcccg cttgctgtcg 2397061 aagacccatt tcttctgctc gtcattttcc acccattctt taaacacctc agactcaacg 2397121 gcaatgtctt tcggaatgaa ataagctccc gtttcattta cgatcgaaaa tccgaggatc 2397181 ggctcttcat gataattatc gccaatctgt tcaacgacaa atgcggatgg agaaaccaat 2397241 atatcgcttg tcacgtctgt gactgttttg acattaatgt cttccaacga ttgatcctgt 2397301 tctgcttctg cactgtcttc tccaagccgt tcaagaagcg tgttgaagcc aagatcttta 2397361 aagatggcaa tgacctgttc acgattaaag ccttgatatt ccaggccgga aacagatacc 2397421 tcaatcggag catccgtcat aattgtcgca agctccttgc tcatcaatgc ctgatcctta 2397481 aactcctcaa gcttttcctt caatttcttt ccgctcacct cgtcaatgga ctccagcagc 2397541 ttttcaacgg aatcaaattg ttttaaaagc ttaatcgcag tcttttctcc gacgccgggc 2397601 acacccggaa tattatctga ggaatcgccc atcagaccct tcatgtcaat gatttgttca 2397661 ggcgtaagcc catatttctc tttgacatgc tccggtgtgt aaaattcaac atcggtaatt 2397721 ccctttctcg taatggcaac tgtcgttttg tccgttgcca gctgggttaa atccttatct 2397781 cctgagaaaa ccttaacttc aaatccgtct ttttcagccg atttggccag tgtgccgata 2397841 atatcatccg cttcatattg ttccagttca tagcggctga tctggtaggc atccagcagc 2397901 tcgcggataa acggcatttg ttcggaaagc tcaggcgggg ttttctgtct gccgccttta 2397961 tattctttaa atgtgccgtg acgaaatgtt gttttcccgg catcaaacgc aaccagcatg 2398021 tgcgtcggtt tttcatcctc aagcattttc atcaaaatca tcgcaaagcc gtatacagca 2398081 ttcgtatgaa cacctttatc attgcttaac agcggcaatg caaaaaacgc ccggtaagcc 2398141 agactgtttc cgtctacaag cactaatttt tttcgttccg tcattcaatt tcctcctaag 2398201 aagcctcagg cttccattca tctcttacat agtcattagc tcctcttatt ttaacaaagt 2398261 tcaatttgaa aggaaaatac gtgaactata agagaagaca caaaaaagga cgggaacaca 2398321 aataggttcc cgccgtcaaa attggctcct tggatgaagg ggttctacta catcctacca 2398381 gcataggttt aacagtgcat gaagatattg ttaaaccttt gtaaacatta ggcggacttt 2398441 tcagcggccc gtttcagcgt cacggtaaag acagttcccc gtccaagctc gcttgtgaca 2398501 tcaattttcc cttcatgagc ctctattaaa tgcttgacaa tcgctaggcc cagcccggtt 2398561 ccgcccgaat ttctgcttct gtctttatct acacggtaaa agcgttcaaa gatgcgcgga 2398621 atttcttctt tctgaattcc gattccagaa tcggcaacct caatctgaat gtctttttct 2398681 ctgggcttta cattgatagc cacggagccc ccctcaggcg tgtaggttaa tgcattgttt 2398741 acgagattaa gaaatacctg tttcagcctg tacgggtcac cagatacata ttgagggtct 2398801 ttcgggacat tcaggtgcaa ggagatgcct ttctcatccg ccttatgctt cagaagcgtt 2398861 tcaatctcac caagcatttt ggccggctca aacgtttcga tactgagcgt gaaattttgc 2398921 tgctcgattt ttgagagatc gagcaaatcc tgaaccaaag actgaagcct ttcgctttcc 2398981 ttaagaataa tagagagaaa ttcagaaagc gcctctttgt cttccatcgc cccgtccaat 2399041 aacgtctccg taaacccttt tatggacgta atcggtgttt tcagctcatg agaaacattg 2399101 gccacaaaat ccttcctcat ctgctctaat ttcttcgttt ccgtcatgtc atggaaaacg 2399161 agcacaattc ctttccattc atcgtccggc cccataatcg gaacgccgtc cacttcaaaa 2399221 taacgccgtt ctattttgat cggcagtctt aacagcttgc atttctttgt ctccgtcata 2399281 aaaatgtctt cgacaagctg gatcacttct tcatgttcaa atgcatcgtg ataaagacgg 2399341 cgcagcatat gattcggatt gatatgaaac tgcttggcgt aagacctgtt tacgagatta 2399401 ataaagcctc ttccgtcgat cataatcagc ccggagccaa tgttttcaat gactgtcagc 2399461 agccgatccc gctgcatttc ctgcgttcgc gtcatttcca tcagatcaat ggcaaggctg 2399521 ttcatcgcat gtcctagctt atcagaacgc ctaatatagc cgccgtacgt ccgtgcatcg 2399581 tagttgccct tagagagttc tgtggctaca tttgtcgctg actcaattga ccttttataa 2399641 cgtgaggtca tgctggaata aaaataaaca atgacgataa atgcggtaca aagactggcc 2399701 gtcagcatcc cccacaattc gccttttaag ccgtcgcttt tttcagaggc ggaaagcagc 2399761 acatatcctg ttttttcacc ttcgcttcta agtgaaagtc cgtaataaag cttgttatct 2399821 gttgttgaca gaataccctc atggccagaa acaagcgcct gcaccttttg ggaatcagcc 2399881 gatctaccgt ttgacccata cagcacctta ccgtctgtat cgataacgga tgcgctcaca 2399941 tcaagcgcgc cgcctgcatc tttaatgatt ttctcatttg cttgattatt cagattgccg 2400001 gcatcaagaa gcgaagccaa gtattttgct tctttttcaa tgtgttcctc tgctttcctt 2400061 tgatcagatg tttcaaaaag ctgctgtaaa aacagcccga ggacacaaaa caccagaatc 2400121 atacagacaa cgaatacaga aaaaaggcgc acacggtatt tattcattca tttttggctc 2400181 ctccagttta taccccaatc ccctaatcgt tttaatgtag atcggttttt tggtattgtt 2400241 ttcaattttg tcgcgaagat ggctgatgtg cacatcaaca attctcgtat ctccggcaaa 2400301 atcataattc cagactgcgc tcagcagcag gtctcttgtc agaactctgc ctttatgtct 2400361 gcctaaatag agcagcagtt cgaattcttt cggtgtcagt tcaagctgac tttctttaaa 2400421 gtacgcttca taatgatcag gcaggatttt cagatcgccg attacgatct ggccttccat 2400481 ttcatcgttc ttcatctcac tagagggcgc agctatttcc gaacgcctta aaatcgcttt 2400541 gactctcgca tttacttccc ttggactgaa cggcttggtc atataatcat cagcaccgag 2400601 ctccagccct aatactttgt cgaattcctc atccttcgct gtcagcatta aaatgggaaa 2400661 catcagtttt tgctgtctca gctgcttgca tacttcgatt ccgtccaatt ttggaagcat 2400721 cacatcaagc acaatcaaat caggtttctc tgtttccgct tttttgagtg cttcttcccc 2400781 atccgaggcg gtaatgacat catagcctga ccgttccaaa ttgtactgta aaagagtaac 2400841 aatagattct tcatcatcca caactaaaat tttcttgttc atgctgtgcc tccagtatta 2400901 taattccccg acatcctatt tctctatttt atgtcatctt aacatgtttc atgattttat 2400961 tttagcgaaa gcaggacatt ccgacaattc gccttttaca tcatttttaa aagaaataaa 2401021 gacgtttatg atagcgcttt catttatagt aaaaagagaa aggctgtatt aagcaagcct 2401081 ttctctcttt ttattaggat aatactttca tgacattttt gacagattca actgatttat 2401141 tcagctgcgc tctttcatag tctgtcagtt caagttcaat gatttgctca agaccgttgc 2401201 cgcctacaat tgtaggaaca ccaaggtaga tgccttcata gccgtattcc ccttcaagat 2401261 aagcaattgt aggaaggacg cggcgctgat ctttcaagat cgcttcgacc atttctgtca 2401321 gagaagccgc aggcgcataa tacgcgcttc cgtttccaag aagattcacg atttcgcctc 2401381 cgccttttct agtgcgctcc acaattgcgt caatccgttc tttcggaata agagtttcaa 2401441 gcgggatacc gccagcataa gaataacgca caagcggaac catatcgtca ccgtgtccgc 2401501 cgagtacgaa accagtcaca tctttcactg acaggtttaa ttcctctgcc acaaatgttc 2401561 tgaatcttgc cgtatcaagc acacctgact ggccgattac acgctcttta gggaagcctg 2401621 attctttgta caccgcgtat gtcattgcat caacaggatt tgtcagcacc acaataatag 2401681 agtcaggaga atatttcacg atttcctgcg taacgcttct cataatcttt tcgtttgtag 2401741 agaccagatc atctctgctc ataccaggtt ttcttgcgat accggctgta atgacaacaa 2401801 tgtcagagcc ggctgtatcc tcgtaattgg atgttcccgt aatttttgcg tcaaagcctt 2401861 gaaccgggct tgcttcaagc atatcaagcg cttttccctt tgtcgggttc tccaattgcg 2401921 gaatgtcaac aagaacaacg tctgccagct ctttttgagc gattaaaaat gcagttgtag 2401981 ctccggtaaa acctgctccg ataacagaaa cttttttacg agtatttccc atgtctctct 2402041 tctcctttat ggctagtttt aggctttttc cttgcttagt ccatgttttt gatcagttct 2402101 tctccgaact ctgaacattt cacttcagtc gccccgtcca ttaatctggc aaaatcgtaa 2402161 gttacgactt tagaagcgat tgttttttcc atagatttga taaccaaatc agccgcttcg 2402221 ttccatccta aatgctcaag aagcagaacg cctgaaagaa taactgaaga tgggtttact 2402281 ttatcaaggc ctgcatattt aggagccgtt ccgtgcgtcg cctcgaaaat cgcatgtcct 2402341 gtttcgtagt tgatgttcgc tccaggagca atgccgattc cgccgacttg cgcagcaaga 2402401 gcatcagaaa tgtaatctcc gttcaagttc attgtcgcaa cgacatcaaa ctcgtttgga 2402461 cgcgttaaga tctgctgaag gaaaatgtca gcaatgctgt ctttgataat gatttttcct 2402521 gctgcttccg cttcgctttg cgctttgttg gcagcgtctt ttccttgttc ttcagcaatg 2402581 cggtcatatt gagcccatgt gaagacttta tctccgtatt ctttttcagc aagttcatag 2402641 ccccagtttt tgaaggcgcc ttctgtgaac ttcatgatgt ttcctttgtg aacaagtgtt 2402701 acagatttgc ggccatgctc gatcgcataa tcaatggcag ctctgaccaa gcggcttgtt 2402761 ccttcttctg aaacaggctt aatgccgata cctgatgtct cagggaaacg gattttattg 2402821 acgtttaact cattttgaag gaagctgata agcttttgca cttcttcaga gccttttgca 2402881 tactcgatgc ctgcgtaaat atcttctgta ttttcacgga agatgaccat atcagtatct 2402941 tcagggcgtt ttaccggtga cggcactcca gtaaagtatc ttacaggtct taagcagacg 2403001 aataggtcaa gctcttgtct gagcgctacg ttcaaagaac ggataccgcc gccgacaggt 2403061 gtcgttaacg ggcctttaat cgcgatgaaa tattcgcgga tcacatctaa tgtttcagca 2403121 gggagccact cacctgtttt attataagcc ttttctccgg cgtaaacttc tttccatgta 2403181 attttctttt cgcctttgta tgctttttct actgctgctt ccaaaacctt cgaagccgcg 2403241 ttccaaatat caggaccggt tccgtctcct tcgataaatg ggataatcgg gttgtttggt 2403301 acgtttaata ctccgttaga gactgtaatt ttttcacctt gtgccacaat aaaaacctcc 2403361 cagtatgtaa ttcatattta gaaaacattt tatttttctt atatagaaaa taaaatgatt 2403421 tttcctaaca ttcaatttaa agtgtaaccc aattttgatg tctgaacaag aggctaacct 2403481 cattgacgca agccagcctc caatggttct ttaggctctt tcttcaatcg gaacgaattt 2403541 ttgtttgtca gggcctgtgt aatctgcccg cgggcggatc agacggttgt tgtcatactg 2403601 ctcaagaata tgagcgagcc agccggacat tctgcttaca gcaaaaatcg gtgtaaacaa 2403661 atcatggtca ataccgaggc tgtgatatac agaagccgaa tagaaatcaa cgttaggcgg 2403721 aagctttttc tctgatgtga cgatgtcttc tatacgaatc gacatctcat accatttgct 2403781 ttcgcctgtc aggttggtca ggcgcttgct catttctttc agatgcttcg cgcgcggatc 2403841 accatgctta tacacacggt ggccgaatcc catgattttt tctttctttt caagtttagc 2403901 gcggatgtac ggctcagcgt tttccacttc accgatttct gtcagcattt tcataacgcc 2403961 ttcattcgct ccgccgtgaa gaggcccttt cagcgcgccg attgctgcag taatgcctga 2404021 atagatgtca gaaagtgttg cgacgcagac cctcgctgtg aacgttgacg cgttcagctc 2404081 atggtcagca tgtaaaatca atgctttgtt gaaggcttca acttcaattg gtgaaggctc 2404141 ttcaccgttt aatgtgtaaa gaaaattctc cgcaataccg taatcttctc tcggttcaac 2404201 aggctcaaga cccttgcgaa ttctggaaaa cgctgcaacc aggccaggca cctttgcctg 2404261 aaggcggatc gcctttctgt agttggcttc cgggttcatg gtatcagcct cgctgtcaag 2404321 caggcctagt aatgaaattg ctgtccgaag agcagccatg ggatgaacat tttcgaggga 2404381 ataagatttg aagtgctcaa taatttcttg cggaacggca gcttcctttg caagctgctg 2404441 ctttaactct tcaagctctt ttttgtttgg cagccttaga tgccaaagca agtagatgat 2404501 ttcttcaaaa cttgcattct ctgtcaaatc atcgatatca taccccacat atgtaagggt 2404561 atcatcaata atagaactaa cagatgatgt tgttgctaca accccttcaa gaccgcgtgt 2404621 cgctgtcata tataacatct ccttttcaat aaatttcccc tttaagagtg ttgtaaaaac 2404681 atgaggctta cttaaaaagc acgatgcaag tatttctctc ccccaaaaag aaaatgctta 2404741 cattttactg gctgctggaa ctaaaaccct ttgcttttga aagaacataa caaattttta 2404801 taagcttatt taagtttaag cctattctca ttataaacaa taatcagaca tttgttaaat 2404861 gtttacctat aatttttttt ttccattctg tgatttcccc gaaaaaacgc ctttatttgc 2404921 gggtttttgc ataaaaaaaa gcggctttaa ggccgctttt ttttatgaag tgaacagttt 2404981 tacgatctgc atggctaaat aagcaatccc cgctccgatc agcggcccca ccgcaactcc 2405041 tccaaaaagc gcgactgcaa gaatggtccc gatcacgaga gcagttgtaa tatgcggatc 2405101 attttcaagc agggtcaggc cgttttttgc aatcagcgcc actgcgatcc ccgctccaag 2405161 ggcgatccat gcgtaggaag accgcattgc ttctccaagc tgcttaaatc cgatttctcc 2405221 cgtggcaatc gggacaagaa cggcgatggt aataatggtc acaccccagt taatgccttt 2405281 tgactggatg gtcggaaata atttctgatc aagcccaacg attttgatga tcaaaaggac 2405341 ggatacagca aagagcaatg attggttttt tgcgataagt gcgatagcca agagtaaaat 2405401 taaaaataaa ttcgcttgtg taaacacatg ccatccctcc tttaagatga atgtattcat 2405461 attcagccgc agcgtgaata catataaaaa ataggacatg ctgacgagag gaggaccgtt 2405521 tttgtgaatc aatcttatat cactattttt ttcagaaccc tctttgtcat atcaatgacc 2405581 gcagggtcga tagctgcggc ctattattcg tttccgttaa cttatccgtt cctgatcgcc 2405641 cttattctat cttcagtgat tcatcctgtt gtcgattatt tggacaaagt gacaggattc 2405701 ccccgaacga taaatgttct gggcgttctt gctttttttc tgctcgcagc cttcggcgtg 2405761 ctcaccattc tggtagccga aatcgtaacg ggaacagcct atctagcaaa aacgctgcct 2405821 ccgcatatca gcacgtttat ttcatattgc gaaaaattgt ttaccactca tattcagccg 2405881 ctctataacg agttaactct tttgtttcaa gaattggaaa cgaaccagca ggcttccatc 2405941 gtcactcata tccagacact cggtgattct gccgctaaaa atgccgggct cctgctgtcc 2406001 cacattctag agatgatccc gagatttttc gctcttcttc ccaatacggc ggcggttctg 2406061 attttttctc ttctggcaac cttttttatg acaaaggatt ggcataagct gaaagccatg 2406121 cttgttttaa ttctgccgga tcgtgtgaca gctaacagca aagcaatcag cagcgaatta 2406181 aaaaaagcaa tgactggttt tatcaaagca caagccgtcc tcgttttcat cacgatggtg 2406241 attgtattta tcggcctttc tctcttaaag gttgaacacg ccgcaacaat tgctttttta 2406301 atcgggcttg tagatcttct cccttactta ggtgccggct ccgtatttgt gccctggatt 2406361 ttgtatttat cgattacggg ccagctgccc caagcaatcg gaattggtat cctgtacctc 2406421 gtcgttctta ttcagcggca gctgacagag cccaagatac taagtaaatc tatcgggatc 2406481 gatccgctgg caacactcat cgccctgttt gccggcttta aattattcgg gtttttagga 2406541 ctgattgcgg gaccggctgt actcgtcatc atccaagctt tcatcacaac aggcgcatta 2406601 aaagaaatat ggtcctatat caccgttcag caaaaataaa acggcagccg ttttttcatg 2406661 gctgccgttt tttatttgat gatgatccgc ttattcttcg acattcctct cagccatttg 2406721 aacagaatcg gcttacacca gccgcgggta aacgggataa gaagacaggc gccggccaaa 2406781 tctgataaaa agcccggaag catcagcaat agaccgccaa tgaaaatgca cagaccgtca 2406841 gcaatcgctt ctcccggcat tttgccatat tgaagatcac gctgaacctt ataatacact 2406901 tcggttcctt gtttttttgc agctgctgcg ccgataatgc cagtcagaat catgaataga 2406961 actgtcggca aaataccaat cagatttcct aaaaatagga atataccgat ttctattgcc 2407021 ggaaacacaa taaaaagcaa aaacaaaaat ctcatatcca agccccccac acgtgtaaca 2407081 cgttctgttc aacaaaaggc atgataaaga gaaaaggaag ggattcccct tccattttca 2407141 cctgtaatta aagaacgctc gcacggcctt gatagactgc gcctctggaa gcgtcaactg 2407201 taatatcctg gccatctgtc aaaatagatg tcgcattttc cagacccacg ataaccggga 2407261 tgccaaggct taatccgact accgcagcat ggctagtcaa accgccttct tctgtaataa 2407321 gagcagacgc tttttcaagg gatgcaatca tatcacggtc agtgcttttg gtaacaagta 2407381 ccgcaccgtc agtcattttt tgctcagctt cttttgcatt ttgtgcaacg acaaccggac 2407441 cgtaagctga tttgcgtcca atgccttggc ctttagcgat gatatcgccg acagtatgaa 2407501 ccttcattaa gttcgtagtg ccggactcac cgacagtgcc agctgtaata acgataagat 2407561 cgccgtgttt tacaattccg ctgttcaatg atttttggac agcatcctca agcatctcat 2407621 ctgttgagct cgcattttgg ccgctttccg cgaatacgcc agatacgagg gcaagctttc 2407681 tggaaataga gtcatttaca gtaaccgcaa caatcggagc ctgcggacgg tattttgcaa 2407741 tcatacgtgc tgtatggccg ctttctgtcg gcgttacgat cgcagcagca ttcaggttaa 2407801 tcgccgtatg tgcgacagat tgtccaattg cgtctgtaat tgtcatgccc acttggtctc 2407861 tgcgttttga gagaatttct ttataattta atgcttcttc agaacgggac gcgatgttat 2407921 gcattgtttg aactgcttca accgggtaac ttccggcagc agtttcacca gaaagcatga 2407981 tcgcatctgt tccgtcgaag atcgcgtttg caacgtcact tgcttccgca cgagtcggac 2408041 gcgggttgcg ctgcatgctg tcaagcattt gtgtcgctgt aataacaggt ttgcccagcg 2408101 cgttgcattt tttgatcagt tctttttgca caagcggcac ttcttcagct ggaatttcca 2408161 cacctaagtc tccgcgtgca accattaagc cgtcagacac ttcgagaatc gcatcgatgt 2408221 tgtcaacgcc ctcttggttt tcgattttag ggatgatttg aatatcctga gcgttgtgct 2408281 cttcaagaag ctcacggatt tcgagcacat ccgtagaacg tcgaatgaaa gatggtgcga 2408341 tgaagtctac tccttgctca ataccgaaaa cgatgtctcg cgcatccttt tcagtaatcc 2408401 ccggaagatt gacacttacg cccggtacgt taacaccttt tttatttttg agtgttccgt 2408461 tgtttaatac ttttgttttg atttcgcgtt tagcggcatc tacatcaagt acctcaagac 2408521 cgataaggcc gtcatctaac agaatcgttg aaccttgttc aacgtcatgg actaaacctt 2408581 catatgtcac tgaaatttta tctgttgttc ctacaacctc gtccattgaa ataatgagct 2408641 ctttgcctgt ttcaagctca ataccgccgt tttccattgt atgtgtgcgg atttcaggac 2408701 cttttgtatc aagcagaatt ccaacgttct tgccaagttt tttacttgct tcgcggatat 2408761 ttttaattct tgcaccgtgc tcctcaaaat ctccgtgaga aaagtttaat cgagccacgt 2408821 tcattcctga ctccattaat ttcgtaagca tttcaatact ttcacttgcc ggaccgatgg 2408881 tacaaacaat tttagttttt ctcatttggt tcacttcctt ctgaaatctt cagccttcag 2408941 ctgtacatta gatagacagt tcttttgaaa gctgatacat gttttgctca actgtgtgtt 2409001 ttgtctcaag tatttctata atatcatggt ctacaagctt attgttttgt atacctacac 2409061 agcgtccgcc ttttccttca agcagcagtt caactgcata tgcgccgaga cggcttgcca 2409121 acacacggtc agcagcactc ggagaacctc cgcgctggat atggcccaat acagataccc 2409181 tagtttcaag atttgtttct tcttcaatgc gtttcccgaa ttcaacaccg ctgcctacac 2409241 cttcggcaac aataataata ctgtgcttct tgccgcgttc gtggccgcgt tttaagcggg 2409301 caatgatttc gtgcatgtca tagtctgcct cagggattaa gatcgattct gcgccccctg 2409361 caagaccggc ccacaatgcg atatcgccgg catgacggcc cattacttcg attacatatg 2409421 tacgttcatg agaagtcgct gtatcgcgaa tcttatcaat tgcgtcaatt actgtattta 2409481 aagctgtatc gaaaccgatt gtaaaatcag tgcccggaat gtcattatca attgtacccg 2409541 gtacacctac acatggaaac ccgtgttccg ttaatttttt cgcacccata taggaaccgt 2409601 ctccaccgat aacaacaagg ccttcaatac caagcttctt caagtttgct atcccttttt 2409661 cacggccttc aactgttttg aattcaggac atctcgccgt ataaagctta gtccctccac 2409721 gatgtataat atcgcctact gatccgagtt caagcttttc aatctttccg ctgatcaatc 2409781 ccgcgtatcc gttgtaaata ccgtaaactt caacgtcatg atagatcgct tttctgacta 2409841 ctgcgcgaac tgctgcgttc attcccgggg aatccccgcc gctcgttaat acccctattc 2409901 gtttcattct ccattcacct cagcaacata tatgattaaa cataacatga tcattgccct 2409961 aaaaacaatg aaaagggatc tccatcctcc ctatgaaacc ttacctatta tacaattaaa 2410021 taaattgttt ttaaataaaa tttaaggaat gtcacaaaaa ataaacgtga gccaaaggct 2410081 tcacgtttat ttagtttacc ccgatatatt gatcttcaac cgagactttg ccaattgctt 2410141 tatatttttc ataacgctgc tgaactaatt cttcttcgct cagcttcagt aaagttttta 2410201 acgattgttt aagggtttcg tccatatagc ttgcctgcag cttcacatca tggtgcgctc 2410261 cgccttttac ttctttaatc atatgatcta taatacctaa ttcttttaaa tccggcgcag 2410321 tgattttcat tgtttctgct gcttttttag caagactgga gtccttccat aaaagtgccg 2410381 cggcaccttc cggagaaata acagaataag tagagttttc cagcatatgc aagtgattgc 2410441 ctacacccag accaagggct ccgccgcttc cgccttcacc aatgacgatg cagataacag 2410501 gcactcgaag gccggccatc tcaaacaggt ttttggcaat agcttcactt tgtcctcttt 2410561 cttcagctgc tcgtccaggg tatgccccct tcgtatcaat aaaacagata attggtctgt 2410621 taaatttgtc agcctgtttc atcagacgaa gcgcttttct gtagccttct ggatgcggca 2410681 tcccaaaatt gcggactagg ttttccttcg tgtctttgcc gcgctgatgc ccgattaccg 2410741 ttacagggag gccgtggaac ttcgcaatcc cgccgacaat ggcttcatcg tccccgtacg 2410801 ctctgtctcc gtgacattca aaaaagtcgg taaacaggtg ttcgatataa tcaagagttg 2410861 tcggacggtc cgccagacgc gcgatttgaa cccggtccca cggcttcaaa tttttgtaaa 2410921 tatcatcctg aagcttagcg agacggtctt cgagccgttc gatttccgca cttagatcca 2410981 tatcggaatc ttgggtgaat ttttttagtt cggcgatttt ggtttgcagt tcaatcaccg 2411041 gtttttcaaa ttctaatctt ggagccactc aatgtcacct cctgtttgat gcatatccag 2411101 cagattttct aacgtttttt tcatatcgtc gcgatgaata accgcatcaa gctgtccatg 2411161 ttttaataaa aactcagccg tttggaagtc ctcaggcagt ttttctccta ttgtctgttc 2411221 aataatccgt cttccggcaa aaccgatcag cgcgccaggc tcagcgaaat tgtaatcgcc 2411281 aagggatgca aagcttgctg atacgccccc ggtagtcgga tgcgtcatta ctgaaataat 2411341 aagaccctgt tcttcactga acagttttaa cgcagagctt gtctttgcca tctgcatcaa 2411401 acttaatacg ccttcctgca ttctagcacc gcctgaagcc gtaaaaataa taaacggaac 2411461 tttatcagct tttgcttttt caatcgcaag cgtgattttt tcaccgacga ctgaacccat 2411521 gctgcccatt ctgaatgaag agtccatgac ggcgacaaca gccgggtgtc cgccgatggt 2411581 gcccttgcct gtcacaacag cctcgtttaa ggatgttttc tcgcgatctt tttcaagctt 2411641 ttccagatat cccgggaaac caagcggatt ttccgagagc attccctgat taaattcctc 2411701 aaaggattgt tcatccatca agctttcgat acgctgtttt gcgttcattg ggaaatgata 2411761 atcgcagttc atgcataccc gcatattttt atccaactct ttagtgagca tgattttttt 2411821 acacttagga cattttgtca taatgccttc cggaacatcg tgcttcgctt gatcagacgg 2411881 tacggaagca tactttttct ttttcgtgaa tatatccttt aacaaatgat tacctccctt 2411941 ttgtgaaggg ttctcttcac cgcatgtcat caaacagata gacttgctaa taactttacc 2412001 gaaactattg tacttttttt gtcaaacgct gtcatcctca attcgacaac tttttattcg 2412061 atgacgtgct cggaaaggct tgtatgaaat cagataaggt gttgaaacga caaggttgac 2412121 agcgcattca aaaataatgt taaacccggc tgaaattttt ttaaggctaa ccccctaaaa 2412181 aaatttcagc cgtcagttta acttgagaac agcgcgccgg tctccgccaa cgcgctgcca 2412241 tttttggaat gaattaaaat tattcaccaa taatcgtaag ttttcttgtt ttttctgcga 2412301 cttcctcagg gtcaacagtg attcttgcaa cacctgtttc catcgcagct tttgccacag 2412361 ccttcgcaac agcaggcgca acacgtttat caaacggtgc agggatgaca tagtctgcgc 2412421 taagctcatc ttctgaaacc agtgaagcaa tggcttcaac cgctgcgatt ttcatttcct 2412481 cgttaatatg agtggcacgc acatcaagcg ctccgcggaa aataccaggg aatgcaagaa 2412541 cattgtttac ttggttcggg aagtcagaac ggccagttcc gacaacgctt gctccggctt 2412601 cacgcgcatc ttccggcatg atttccggat ttggatttgc cattgcaaag ataatcggat 2412661 cttttgccat gctttgaacc atttcttttg ttaacgcgcc tgctacagag acaccgataa 2412721 atacgtcagc atcaacgata acatctttca gagaaccgtc tttgcgatct tggttcgtga 2412781 acttcgccac ttcatttttg acatcgttca tgccgttcgg gcgcccttca taaatggccc 2412841 ctttggaatc gcacatcaca atgtcgcgaa cgccataatg atgaagaagc ttgataatcg 2412901 caatgccagc cgcacccgcg ccgtttgcga caactttaat ggatgacatg gattttccag 2412961 acagtttcag cgcgttcaca agacctgcta cggttacaat ggcagtaccg tgctgatcat 2413021 catggaaaac cgggatgttt gtttcttttt tgaggcgctc ttcaatgata aagcagtttg 2413081 gcgctgcaat atcttcaagg ttgacgccgc caaatgtcgg ttccagcaat tttacagttt 2413141 caacgatttt atcaacatcg tttgtgttta aagcaatcgg gaacgcatct acgcccgcaa 2413201 agcttttgaa aagaactgct ttcccttcca taacaggaag cgccgcttca gggccgatgt 2413261 ttccaaggcc aagcacagct gtaccgtcag ttacaactgc taccatgttc cccttcattg 2413321 tataatcata tactttgtta atgtcttcat gaatatcctt acacggttct gcaacacccg 2413381 gagaatacgc gaggcttaaa tctttcgcat ttctgacctc tacttttgat ttagactcca 2413441 gtttcccctg gttgacttta tgcaggtgta atgcttcttc tcttaatgac attctcctaa 2413501 acactcctta tggatatttt ttgattcgta tactgctgcg ttgattgctg cattctgcgg 2413561 agtaaatcta tctgaatatt taaacaggat cacataattg ctccaattgt ataacaaaaa 2413621 gcgaatcgtt accactgttt taaaacgacg tttttttgac ccaacagctc ttttaagcga 2413681 tataacacct ggtgatctgc attgatatgg aacgactcag gtagcttaat cgtctgtttt 2413741 tgcctttcat aatagagata aacgcctgtt tcccctttat gctccagcaa aatgcgctta 2413801 atctttgcca ggatctcctg gctgtgctga ctgctttcta tttttatata aaccgatggc 2413861 gctttttctg catccatatc ttctaataat tctgcccggg acatgatgaa ttggatctta 2413921 tcttgtctaa cttcacattt ccccgcagtg aacaaaagag cgccttctct taaaacggga 2413981 gaaagctgtc tgaattgttc agggaagact acggcttcca tctcgccggt ttcatcactg 2414041 agcgttaaaa acgccatgtt ttgacctgtt ttcgtccgaa tcgttttgat cttcgacagc 2414101 agaacgccta gtgaaagctg ccttttgact gcccgctgag cctgcagaat ggagactgct 2414161 ccttgcgcag tgagctgttt tcggaaggcg gagaggggat gatttgaaaa ataaatgcca 2414221 agcgtttcct tttcaaacgc aagtaaatcc accagaggaa gctcctccgt ctccacatac 2414281 ttcggcttaa ttgaaaacga ttcatctaaa aacaatccca tttggtcatc gtccgcggcg 2414341 aatagctcag catgttccaa agcaacatca atggatgcga gcagcgtggc ccggttttgg 2414401 ccgaattcgt ccatcgcacc agaaaagata agtgcttcaa gcattttgcg atttacgctt 2414461 tttgacggca cgcgaaagca gaaatcgaaa agatcttcaa atggtttctc ttttcttgct 2414521 ttatatatat ctttgactgc tgagacgcct acacttttta tcgcgcggag gctgtatctg 2414581 acagatccgt tttcaactgt aaacggaaaa ctgcttttat tcactgacgg aggaaggata 2414641 cgaatcccgc tcccctttgc ttcgtaaaga tattgagaga ttttatcctc attgccaatg 2414701 acgcttgtca gcaatccgca cataaaatat aacggataat gagctttcaa atacgcaagc 2414761 tggcacccga tcatgctgta tgccaccgca tggcttctgt taaagccata gtttgcgaat 2414821 ttgacgatta aatcgtagac ctcatttgca gtgtctacag aatactcctt ttttaagcac 2414881 ccttcaacaa aatggcttcg ctctctgtcc aggatttctt ttttcttttt gctgaccgcc 2414941 cttctcaata ggtccgcttc gcctaaagaa aaccccgcca tacgggaagc aatcatcata 2415001 atttgttcct gatacacaat gacgccatat gtatcttcca aaatgctcct taaatcttca 2415061 tgaggatagt gaacaggcgc ccgaccgtgt ttacggtcga taaataacgg aatattttcc 2415121 atcggacccg gccggtacag tgcattgacc gccacaatat cttctaggcc cgaaggtttc 2415181 agccgtttca agacgcttct catccctgca gattcaagct ggaaaatgcc tgtcgtatcc 2415241 ccttttgaca gcaaggagaa cgttttgtca tcgctgtagg aaatacttga aaggtctatt 2415301 ttaatatttt cttctttttc aatcattgaa gtgatggatt caataagtgt cagattcctc 2415361 aaacctaaga aatccatttt taaaaggccc aagtcttcaa gatggtccat cgcgtattgc 2415421 gttaaataga tcccttcatg cccttcttga agcggaacaa catctgttaa cggttcttca 2415481 ctcaggacaa cgcccgctgc gtgggttgat gcatgccttg gcagcccttc tattttccgg 2415541 gcaattgaat agacttgctg aagcaggctt gactcccgaa gccgcttatc cagctgcggt 2415601 gactgctgtc tcgcttcatc cagcgtcatt cccggtcttg aaggaatgag ttttgcaagc 2415661 tgatctgcct ccttcgggct gacgccgaat actctgccga cgtcccggag cgccgccttt 2415721 gccgcaagtg ttccaaaggt gataatctgt gcgacgtgca ttgcaccgta tttctgctga 2415781 acatattgaa tgacttcatc ccttctagta tcgggaaagt caatatcaat atccggcatg 2415841 ctgacgcgtt cgggatttaa aaatctttca aacagaaggt gatgcttaat cgggtcaaca 2415901 tctgtgatat acagcacata tgccacaaga gaacccgccg cagaacccct tcccggtcct 2415961 gtaacaatcc ctttttcatg ggcgtgcttc ataaaatccc acacgatcag aaagtaatcg 2416021 ctgaacttca tccgcttgat gacatcaagc tcatattgaa gacggcgaag gtatcgttca 2416081 tcaggcttgc cgaaacggct gcggagtccc tccatacaga tatccgttaa ataatcatca 2416141 gcggacgttc cgtctggggt cggaaaagac ggtagacggg tctgcccgag actgacgtca 2416201 acccggcatt gttccgcgat ctctacagaa gcttgcagtg cctcgggatg ctctcgataa 2416261 atgttttgca tttcttcgag tggtttcaaa tcgagatcag gcaaatcttc agcgggtgca 2416321 tccgtcagtt tttcccccgc tttaatcgct ttcaaacaac ggtaggcagc cttatcttcc 2416381 ttccttatgt aatgcacatc gcctgtggcc gtaacaggga tacccgtttc ttctgacagc 2416441 tttagaatct gctcagacaa gacttgattc cctttaaaag gctgatagga gaaataaaaa 2416501 gctccctttc cgaatataga ctgaaattcc agcgaggctt gagcagcctg ttcgaacagc 2416561 cctccttcaa gaagcgtttc aatatatcct ttttcgccgg gcgttattgc gataatccct 2416621 tctcgataac tgtgaagcca tttcggcttc agtccgcctt ttgatttaga ttgcagaacg 2416681 ctgctgattt tcagcaggtt ttgatagcct gtattcgatt ttgccagcag gacgagcggg 2416741 tatgcttcaa gctcgctgtc atctgtaaaa acagaagccg tcaaaccgat tattgggttg 2416801 atccctctcg ccttgcaagc tttataaaat tgaatagctc cgtacatgac atgatcatct 2416861 gtcagcgcca aagacgcata tccgagcctg tcagcttcac tgacgagttc ttccacagcc 2416921 gcggcgctgt ttagcaggct atacccgcta tgcacttgca ggtgaacaaa agacatgcta 2416981 tcacctcttt ctcattacga tccatttctt ccttcattat aaggccggtt tccaaaagaa 2417041 acaaatgttc ttttttgact catcatcata cttgtcctga aagctcaata tgatataaaa 2417101 ggtgaggtga taaagatgga tcaggaagca ggatttatgg tgaattttat caatagctac 2417161 ttcattgcgt taggggtgct gatcgggggc gcactcatcg gagggctcgg agcatacttg 2417221 gcaggcgaac ccccgcttac agccattaca aagcttgcca accggttaaa aatatgggcg 2417281 cttgtcgcag ctatcggagg cacctttgat gcggtataca gctttgaacg cggcatactc 2417341 gaaggcaata cgagagatat ctttaaacag cttcttttaa ttatttcggc catggggggc 2417401 gcgcaaagcg gctggcttat tatatcatgg ctgacccagg agcatctttc ttcatgaggg 2417461 tcccccagca ttacaaaaaa ccgggatggc agcgtttttt cgcgggaatg atgtgcggag 2417521 ccgtaatcag ctggttcttt ttcctgttta cttacggaac attccaagag gagcaggtca 2417581 gcctcatcga aaagcaaaaa gagcatgtaa aagacttgaa caatcaaatt tcgatctatc 2417641 aggaagacct ccataaactg aatgaagata ataaaagaaa actgctgatt caaagcgtca 2417701 gcgtcaaatt gctgaatggg gataaatata aaatatcaca gccggataaa acgaaattcg 2417761 aggagcatgt aaaggatgat atttcagagg tgattacaaa agacatagag agcgtctatc 2417821 aaacaaagga tctcttgaag cggacaattg aaaataaagt ctatatgatc aatgaaaaaa 2417881 aatacgaggc aaccgtcaga gaattgatta tttatacgag gctgacagtg gaacttgaaa 2417941 tttctttcgc cacataatta tggatttttt ttaaattctc caaacttctg tcgctttttc 2418001 ccattctttt ttataaacta tatgtgaggc ttaatggcga aaggaaggag gaagggaaat 2418061 ggaggtttac agtgaccgtc agttagcaaa agatcaagca gcccgtctca gacaaggttt 2418121 ttctgcatat gccgaaacaa actcactcgc ttccctcatc aaaaaagaac ttcaatcaca 2418181 caatctccaa gtctacgagg accttactga tttcggctgc tggttcatcc ccgtcacaga 2418241 tgaacactaa gagagagggt ctcccctcta ctcgtgttct ttacataatg tttccagatc 2418301 agctaaaata cgatcagctt catcccagct gtaaatagag gcgcctgaag ctaacggatg 2418361 ccctccgccg ttatatttcc gggcaagtcc gttaatgaca ggccccttcg aacggaatct 2418421 gactctgatt tgatcgtctt cttctacgaa aaacacccag gcgcgaatac ctgagatatt 2418481 gccaagcgtc ccgacaagct gcgacgcttc agaagccgtt gtgccgaatt tttcaagcgt 2418541 atcctttttg atgaaaacag aagccgcccc gttttcggac aaagacacat tttgaaagat 2418601 aaagccgtta agcttcacca cattcagttt tgtttcatac aattgattaa ataactctga 2418661 ggaagagaat ggatactgaa tgagctcgcc tgcatatttt agtgtttttt ccgtggtatt 2418721 cggaaataaa aagcgtccgg tatctccaac aatgccggcg tagatcagct ctgccgcttt 2418781 cgtattcagc ttccagccgt gctcttttcc ttctaaatac agctcgtaaa tcatttcact 2418841 tactgagctg gcgcttgtat cgacccagag aaggtcaccg tatggatctt cgttcggatg 2418901 gtggtcgatt ttcattagtt tggcgcctga aggataacgc tgatcgtcga ttctttcctg 2418961 atttgccgta tcgcagacaa tgacaagtgc gccttcatat gtttcattgt ccacctcatc 2419021 aagggaatat aagaaagaga gggacggttc aggcgtgccg accgcaaaaa tatttttttc 2419081 aggatatgtt tcacgcagga tttccgtaag cccacactgt gatccgtagg catccggatc 2419141 aggacgcaca tgtctatgta agataatcgt gtcatataat gatatggttc tgatcaattc 2419201 tgttttcatt tgatactcct ttattgtttt tattcattaa atcacattct ctgccgacgg 2419261 aaaagaaaaa taacgtcaaa accaagcccg tttttgtata aaatggggtt gtaaactttt 2419321 acgatggagg atttcattta tgctggttct tgtttttttg attgggcttt cagcctgctt 2419381 ttatgtgtac tataaagtaa aaggcgtacg ggcaaagcca tctttggcaa aagaaatatg 2419441 ttcagcaaaa tcaagcatgg ccttagggtc actagtcctg ttctacgggc ttaaccaaat 2419501 gatattattc cattcagtat taacgttagt aatcggcggt atctttatcg tcataggagc 2419561 aggaagcgct tgggcaggtt ataaagcctt caggcattac aatccccttc acgccaaaga 2419621 agctgaaaga gatcacgcgt aaggggcgcc tgaacgtccc ttagcttctt tccatcagct 2419681 gaaccatcag catcgcttta gacacgatat gaccttggct gtgcacttcc acttccattt 2419741 tcccaaactt tctgccggcc tccaagatgc gaggtttgac ttcgatgact gattccatct 2419801 gcacaggctt caaaaagaag atggtgatgc tctctatgac gagttcgccg cgttttttcg 2419861 agcgcaaaaa tcggtttgcc gcttgcgtca aaatggtcgt aaatacgcca taagaaatgg 2419921 ttccaagctg atttgtcatt tgcggcgtga cttcatactc gtaaaccgtt tgatcttctt 2419981 tatcatcacc ctcatcttta aacccccttg aaacgatatc atcaagcttc tccccgacct 2420041 gcggctgctt ttgaatcatt tgaagagctt tcaatacgtc ttggcggctg atcatgccga 2420101 tgagtttttg gtggccgtca gtgacgggaa gcacttcgat cccttcccat accatcattt 2420161 gcgcagctga agcgacagat gttttcccaa taaccgtgac gggatttttg gtcatgactt 2420221 tttctataga tgcatttcgg tcatggccag caatatcttt tgatgtcaga atgccatgga 2420281 ttttcatttg atcgtcgaca accgggaagc ggccgtgccc cgtttcaaaa tttttctcat 2420341 accatttttc aagtttatcc ttaggcgaaa gatataccgt gcggtcagca ggtgttagga 2420401 tgtcctccac caaaacaatt tcttttttga tcagctggtc atatattgcc cggttaatca 2420461 tcgcggcaac tgtaaaggtg tcatagctcg tggataaaat cggcagttca agctcatctg 2420521 ccagctgcac aatgctgtca tccgtgttaa agcccccggt caccaatacg gccgcgcccg 2420581 cttcaagcgc ctgcctgtgt gcattgattc tgtttccgac aatcaaaaga ttccccgctg 2420641 cggtgtaacg catcatcgcg tcaagctcca tcgcgccgat gacgaattta ttcaatgtct 2420701 tatggagccc tgccctgcct ccgagcactt gtccgtctat aacatttaca acctctgcat 2420761 aggtaagctt ttcaatgttc tcttttttct tttgttcaat tctgattgtg cccacacgtt 2420821 caatcgtgct gacaaaccct ttattctctg cttccttgat cgctctgtac gcggttcctt 2420881 cgcttacttt catttccttt gcaattcttc ggacagaaat tttttcaccg acaggcagtg 2420941 aatcgatata cgttaaaatt tgttcatgct tcgttgccaa gcctttcacc tctaaggaca 2421001 gtcttcttgt ttttattata aggtttcaaa ggatttatac gcaatgaggc tggaaaataa 2421061 aaaagaagcc cgaccggctt cttacagcgt tgatttcgtt ccagtcaaac gcaaggacca 2421121 cgtgattcct tttacatcgt aaagcggaaa aacctttatt tttcttttaa atggacatca 2421181 accgctgtct taacaatatt tcgattccct attttagata aaacaaataa aactgcggat 2421241 agccatatcg cccctatggc cgtatagatc aatggatgaa cagctgtgtt tgcgatccat 2421301 tcatttatta atgttctggc atttaccaga ataataaatc ctcctacaag cacacccatc 2421361 aattgcggat gaaacttctg caccagccat gctgcgatag gggcagcgat aattccgccg 2421421 gccattagtg aaaacaccca taaccaattg acgtcctccc atcctaatga aataagaaaa 2421481 ccggcggttg cagatacggc gatggcaaat tcacttgtgt ctacagtccc gacaactttc 2421541 ctcgggctca agcctttgcg ggataataaa atcggagtgg tcaccggtcc ccagccgcct 2421601 ccgcctgtgg catctgcaaa accagcgatc actcccaatg ggatggattg ttttcggttt 2421661 aacggcacat gcttcttctc aagagccggc ttatattgaa ataaaaacct gatcaataca 2421721 tatccgccca gaaggagcaa aaacaaagaa atatagggtt tcgccacatc tccaggtaat 2421781 tggctgagga atgccgcgcc taaaaaagcg cctatagagc cgggaatgac aagctgataa 2421841 acggtttgtt tgtcaacatt gccaaattta atatgcgaca ctcccgatgc ggcagtcgtt 2421901 acgacttccg ctaaatggac agaagccgaa gccacagcag gtgtgatgcc aaacgccaat 2421961 aacaaagaag ttgaggtaac cccataagcc atacctaacg aaccgtctat taactgcgac 2422021 aataaaccaa taaatgcaaa aacgattaat ttcttcatca gaacacccca tctatatcaa 2422081 tcagatattt ttgactcttc attcgaatct aacaatctct tggcgctttc atataaaaaa 2422141 taagaggctt tgataattgc agtttcatct attgtaaatg cagggtggtg ccaatcatga 2422201 tcaccgtctg ttccaaaaaa cgcaaaggat cccggaatat gctcaagata ataagcaaaa 2422261 tcttcccccg cggttgatgg ggcgggatca atgacttgaa gtttcgcttt atgtgcagcg 2422321 tctcgcacca gccccgtaat tgcctcatca ttacaaagcg gcggcggtcc ggaatgccac 2422381 ttcacatttg cctttaacga gaaagcggca gaaatctgct ctgtgactgc aaaaaaacgc 2422441 tgtttcactt gattacgaac ctctgaatca aatgtacgaa cagtgccctc aatgaccact 2422501 gtatccggaa tgacattcca agtgctgccg ccgttgattt tccctacggt taaaatcgcg 2422561 ctttgcagcg ggtttacatt tctgcttaca atcgtttgca gggcgacaat aagctgagag 2422621 gcgccgataa ttggatcaaa accattatgc ggcaatgctg catgagcacc tttcccttct 2422681 atctctactt taaatcggtc aacagcagcc ataagcgggc ctgtttttaa ccctacagtc 2422741 ccaaccgcga tatccggttt attgtgaagg ccaataaccg catcaatgcc atccagttgg 2422801 ccgtcctcta tcacttttgt agcgcctgca cccgcttcct ctgctggctg aaataataaa 2422861 cgaatctttc ctttcagact gtcttgattt tccttcaata aaaaggccgc accaagaagc 2422921 gctgccgtat gaaaatcatg accgcacgca tgcatgatcc ctttatgttt agacgcataa 2422981 ggcaatcctg ttttttcttc aattggcaag gcgtcaatat cagccctcaa agcaatcgcc 2423041 ggaccttctg actcccctgc tatgtctgcg aacacacccg tttttagagc agtagggcga 2423101 atctgtatcc ccttttcttt aaggcatttt tttataaaag cagttgtttc aaattcttct 2423161 tttgacagtt caggatattg gtgcaggtgc cggcgaatgc cgatgagctg cttttctagc 2423221 gttgagagat ttacgggatt agactcctct ttcaacgtca ggatgtcatt tcctgtagtc 2423281 tgatatggat aggagccttc tatatttctc caataatcca aagacatatg ttccgctcct 2423341 ttccctatcc caatatattt tcttcagact cttcaacata agatgaaata aatcggttca 2423401 atttatcagc aagaccgccc gccccaaatc ttatatactt gctggaaact ttcggattat 2423461 cttctttcaa aaagcttaaa aaagataaaa tataaatgcg cctgtaagct acttgtgtaa 2423521 ttccgtactc aaaaaaccag ttatcaatga cattgtatac gcctcggttg acgccatata 2423581 ggttattaca tttcttgtaa aagcagagat ccggaagatt taactcctga tgggaaagaa 2423641 ggctttcttt tttgtttggt gccataatcc caatcagctc aaagcgtttt gcaacgcacg 2423701 aaatatcctt tttaatttgc tttgttaaag actccaaaga atcaaacctt ctttcttctc 2423761 taattttaaa gagaatgctg cattcgattt tttctccata aatgtctcta tgaaagtcaa 2423821 acaaaaaaat ctccaatgtc ttttcaaggt tagagcccac cgtcggtttc acaccgatat 2423881 tcataacccc taaatgaaat tgatgattga ctgtcgccag aaccccataa actccattac 2423941 gcagcccatg tatttttgca tctacatttg ccgtggggaa tccaagcttt ctgcctaatt 2424001 gttttccttt cacaaccgta ccggcaatga tcgtcaaaaa agtcagcctc ctctctcagc 2424061 ttccgcattc gatcagacga aacctaatga tgtgatgaat gtaaaacgga ttgatgctgc 2424121 ggaatgccaa gaccgagatt ttcccgcaat gtcccgccgc gataatcttg acgataaagc 2424181 cctctttctt gaagaatcgg aatcaccttt tctacaaaag catcaagtgt tcccggtata 2424241 tccgacccaa cgataaaccc atccgccgcc tcagcgttga accaagtttc aattaaggat 2424301 gcgacacgct ctggtgttcc gatgaataga gtccgtggaa aagccatttc ctgtgctacc 2424361 tcccgcaatg tcagatttct ggcttttgct tctctcttaa tccggtctgt tgtgctttga 2424421 aacgcattct ttcccacatc gccaatatcg ggaaatggct catccaacgg gtaaacactc 2424481 agatcataat catcaaaaaa acgggccaaa taagtaacag cattttcaat cggtatcaat 2424541 tctgcaaatt cacgatactt cttttccgcc tcttcttccg tatctgccac aatcgggctg 2424601 atccctggaa aaatccgcac acttgaagga tcacgccctt catcagcagc tcggcttttc 2424661 acatccgcat aaaacgcttt tgtctcttct aatgaattgg aatgggtaaa aatcgcatcc 2424721 gcatttttag cagcaaactg ccggcctgtt tctgatgaac ccgcttgaaa cactacaggc 2424781 tctccctgct tagagcgccc gatattcaag ggcccctcta cttgaaaata ctttccttta 2424841 tgattcaggc gatgaagctt cgcctgatcg aaaaactgcc ctgttttctt attgtgtata 2424901 aatgcgtcat gctcccagga attccacagc ccgcgcacaa catccaaatg ctcttgtgcg 2424961 atctcgtaac gttcagtgtg ttctggcaaa ttagacttac tatggttgcg cgccgctcct 2425021 tcctgcggcg aagtaaccag attccagccg gccctgcccc cgctgatatg gtccagcgac 2425081 atcaattgtc tggagatagt gaatggctca gtaaaagatg tagagaacgt ccctactaaa 2425141 ccaatatttt tggtaaccga tgccagcgca gataaaatgg tgatcggttc aaaacggttt 2425201 aaaaaatgag gaatcgattt ttcagaaata aataagccgt ctgcaatgaa aataaaacta 2425261 aacaaacctt tttcagctgt ttgcgccttt ttcatgtaaa attcaatatt cgtgctggcc 2425321 gagggatcaa catcgggatg acgccagccg tcagttgttc ccccgacacc gtgaatcatg 2425381 gctccaaact gaataaaatc tgcacgtgtc atctttttgc ctcctttatc tgtgcatgat 2425441 tagcaagtgc aagatcaagg tgttcaatgc cgatttcagt tatcccttga tactgattgc 2425501 cgcgcccgat ttcgaccaca ggcacatggc gcaccccata tttcacctgt aaaatatccc 2425561 gaagcttttc tttctctgaa acatcgatat tttggaacgg gaaccctttt tcattcaaat 2425621 aattcttgac ttcctcacaa tacgaacagc cttttttact ccaaaccaca atgttcacaa 2425681 catcactcat tcttctgtcc ctccttaacg ttttgcagct aaaactgcat cgctcagcag 2425741 ctgataagac agctgttttt ctacagcatt tttgatcggt gtaaaaataa caaaatcatt 2425801 gattttgtat gtgcctgata aacgtgttaa ttcttctgcc acttcttcct ttgttccggc 2425861 aataatcccg gttttttgca cgatgatgtc atagggctct gtgacgtttt ccagataggc 2425921 ctcagcctgt tcgcgggaac cgacgttgac cttacgcccg tctttcaaaa ccacttttat 2425981 cgattcacgc gacacaatat gtttttccgc ttcttctttt gtatgtgccg caaaaacagc 2426041 gggggcaaga tgaaattcag cctcagatcc tggcgggaga tgcgcgtcaa atgctcggcg 2426101 ggcttccttc agcacttcct cttcaccgtt aataaagtaa gcaaagacaa aagagattcc 2426161 cagttttgca gcagaaatgg cactctctgt gcttcctccc aatagaaaaa tacccggctt 2426221 ccgatcaacc tgcggcctag gacgcaatgc ggcatagcgg tgggtatcag gaaaatcatc 2426281 ccgaacgaaa tgagtaagct cctccagttt ttcatcaaac tgacgcaccg gttttttata 2426341 ttcggcctgc agcgcgtctg tggacagctg aaacccgccg ggcgctttgc ccactccaag 2426401 atctatacgg ccgggagcta acgctgatag aagatggaat tgctccgcta ctttataaga 2426461 gctgtaatgc tgcagcatca ctccgcctga tgctaaacga atttttcttg tgcttgcagc 2426521 aagatagcct aaaagaacct cgggtgcaga ccctgcaatc tcatcattgt tgtgatgttc 2426581 ggccacccaa aatcggtgat atccacattc ttcagccatt tgtgccaatt tcactgtatg 2426641 ctgtaatgta tcagctgctg tctccccttc accaatcaag ctttggtcta aaatacttaa 2426701 gcggatcata tcaccggctc ctttatgtgt tcttttggtt caaataaata ttccggcgaa 2426761 acacggcgga gaaactgcct cgttctgtct tttttggtat ggcggaagac ttcctccggg 2426821 gttccttgtt caacaatgac tccttcatcc ataaaaacaa cttgatcaga gacccttctt 2426881 gcaaactcca tttcatgtgt aacaacaatc atggtggctc cggttttcac gatttccagc 2426941 attacctcaa gcacttcacc gaccagctcc gggtcaagcg ctgccgtcgg ctcatcgaac 2427001 agcagcacat caggatgaat ggcaagcgcc cttgctatcc ctaccctctg cttttgtcct 2427061 cccgataact gactcggata agcgttcaat ttatcttgaa gcccgacctt tctcagttca 2427121 ttttccgcta cggcatacgc gtcttgtttt ctcattttcc gggcaatcgt caagccctcc 2427181 atgacatttt caatcaccgt tttgtgagca aacaggtggt attgctgaaa taccattgcc 2427241 gtctgttttc tgagccagtg aacctctttt ttggacggaa agcggcaatt aatcactttg 2427301 tcatgtatag aaatgatccc ttcgtctgga cgttctaata aattcaggca ccgtaaaaag 2427361 gtggttttcc ctgatccgct cggcccgata atcgtcacaa cttctccctt gcgtaccgtg 2427421 agatttatcc cttttaatac atggtggatg ccaaactgtt tatggatatt tttaatctca 2427481 atcataaagt gcctccttga aatctggctg cctttctctc taatactcca tttgcggatt 2427541 ctaggattag agtcagcacc caatagataa tcgctgctcc gataaacgct tctaaaaatg 2427601 cataattatc agaagcaacg atagtcgccg tccctgtaat ctctgggaca gccactatag 2427661 ccgcgataga ggtggtatgc aaaaagccga tacccaaatt tgtgaagttt gggatggaaa 2427721 ccttcagcgc ctgcggcaat attacacgcc gaaaggtttg gctgtatgtc aagccgattg 2427781 aataagccgc ttcgacctgt ccggtatcca tcgccagaat gcccgaccgg atgatttctg 2427841 tgagataagc tccggcagtt aaagacaagg ccatgatgac aaacatggag accggtatct 2427901 cattagcgga ccagccgaga tgaaaaaaac tgctgacttg atctgcaaca ggcggtatcc 2427961 ctaaataaat caacataatg tgaagaattg caggtgtact tcgaaagaaa gacacataaa 2428021 accttgagca agccaccaag cccttaattc taaaaattct aacaattata tttccaagag 2428081 ccacgagaaa tccaaacaca atcggcaaaa cagccatcat caatgtcaga ggaatggtct 2428141 ttaccatttc tttcatggcg gaaacgataa atggaaagtc aaattgcaat cttctccccc 2428201 ctcatccgaa gaaatatatc aatgtatgtt catgtcaaaa acagtaacaa tccttgtttg 2428261 attcttcttg attcgttttt ctgccactcg aaagaaccat tcgaataaaa ccgctacagc 2428321 ataataaaca atcgatagcg caatgtaaac ttcaagagaa tggttgcttg aggtaatcag 2428381 tgtttggccc cttccggaca tatccataac acctattgaa aaggctagag acgtatcttt 2428441 taaagaactg atcaccatgt ttcccatatt cggaaacgcc tggacaagtg cctggggcag 2428501 aacgattcgc ctgaaggcct gactaccgct taagccaata ctgtacgccg cttccgtttg 2428561 gcctttatct acactgccca cccccgctcg aatgatttct gcggctgccg ctgcattgct 2428621 taacgcgtag gttgcgacag cagcataaaa cgggtccatt tttgatgtat caatcccgat 2428681 aagccccgta agcgccggga tcccgtaaaa cacgatgaaa agctgcacca tgataggcgt 2428741 tcccctgaaa aacgagatat acacttttgc caattgattt acaattggaa tattatagat 2428801 gcggggcagt gccagaaaga gtcctaatac aaaaccgaaa agcaaggaca gtgttaaaat 2428861 gtataatgta accggtaaat aagcggttaa cgtcggcaca aaatctccaa tcatgttcat 2428921 atcaaacgct ttttccatca ctgctccctc tctttttacc taatactgct ctttggaata 2428981 gtcgtcacca agccatttca aactgagcct tttcaacgtt ccgtcatcaa tgatttcctg 2429041 taaggcttta tcaatatcgt cacttaacgt ttgttcattt ttgttaaaca taaaatacac 2429101 tttggcattt gaaagcacat taccgacggt tttttcttta atagtgctcg tcttgttttg 2429161 aaagtctact gcaaaaggcg ttgagatcgt tgcgtccgca cgccccgatt tcagctgatt 2429221 cgcagtctca tttgcgcctt ggccctcata ggcaatctca aacggccgtc cattatcctc 2429281 attccatttt ttcagtacaa gcgctccgtt ggaggttgca ctcgtaatca cccgttttcc 2429341 ttttaagtct tcaattccac ggatcgtatc gttattttga agcacagtaa tttttaaagg 2429401 aaaatggttg taagcaacct tgttaaacag aaattttttc tcacgctctt tgcttttctc 2429461 catttgatgt gccacgatat cgactttatg ctgtccgagg ctgacaagca ggttggaaaa 2429521 ttccatcgtt ttaaatgtga atttataatg tggcaggcgc ttatcaagct ctttgatcag 2429581 ttcgacatca taaccggtta aatcgccttt ttcatcgata aagcaaatat tcggaaattg 2429641 ggttccagtt ccgaccgtga tcgtctgtac cttcttttgc ccggctcccg tcgtttgact 2429701 gcctgcaccg caagctgaca gaactgttat aagcgaaaat aatattgcca tgaatgctgt 2429761 tttcgttttc atctcatcgc cccatttatt tttcaaaact tgattttgaa taatctgccc 2429821 cgagccattt tcggcttagt ttttttagcg ttccgttttt ctccagcttt ttaatcgctt 2429881 gatccgtgtc atccgccaag gtttggctgc ctttattaaa cataaagtac acctcggtat 2429941 ctaataacac gtcaccgact gtcttttggc ggaaggcgtg cgttttattc tgaaaatcga 2430001 cggcaaacgg tgtagctatc gttgcatctg cgcgcccggt ttcaatttga ttggcggtat 2430061 cattgcttcc ctgtcccgca tatttcaaat gaattgggct gccgtgcgtt ttgttgtact 2430121 ttgtaatata atctgccgca tttgacgtgg cgccaactat gactgttttt ccgtgtaagt 2430181 cttttaatgt atgaatcttg tgattatcct ctttcaccgt gatgtacatc ggcgagtagt 2430241 tatatgggac tttatgatac aaaaaacgct tttctcgttc tttatttttg gccatattgt 2430301 gcgcaatcac atcaattttt ttatttccga gactcgtcag caaatttgag aaatccatcg 2430361 ttttaaattc aaatgtatat tgaggcaact ccttatcgat ggctttcatc acttcaatgt 2430421 catacccggt caattcacct ttttcattta aaaacgcaat attcggaaaa tctgttccag 2430481 tgccgactat gaccgtttga gcctgacgat ctgttttgtt atttgtttgc gaacatcccc 2430541 cgccaagtaa tgcaaacact gacagcagca aaaccaatcc tttacgctta ttcataggct 2430601 gcctcacatc atgcccagct gggcgcacct aaaagcgttg ggttaaatcg ttccggaatc 2430661 agaaccttgt gcatcatcac acctatgtcc ccgtcttttt cctgctcaaa atacacttca 2430721 taccctctcc ttctgtacat gtcagcaagc caaggatgct tgcgcgccga tgtgccgagt 2430781 gtcagcgcag gagccttcag catatctcga agcacttttt cttcaacata cgtaagcagc 2430841 ttacttccgg cgccttgccc tttatattcc ggcagtgtcg caaaccacca cacaaatgga 2430901 tattttgaag gaggcgtctc actctcccac gggaacctga ttgtaatcgt tgaaatcagc 2430961 ttcccatccc gctccagcac aatcgctgaa tgatgttcaa tattttctga taccatttgg 2431021 atatcagctc tcgtggatgg ccaatcaata tccagctgcc gaatgggctg aaatgcgctg 2431081 ttaaccagtt tcaacagctc cgatgcatct tcaacagttg ccagtcgaaa aatatcatca 2431141 ctcatttttg tcactcctct tcacaaaata tataattcct atttgtttac taagctttta 2431201 ttgtttatac tataaagcat actctgatct ttgactaatc aaaaaaagta aaccttcact 2431261 tcagtaattt taatgatgaa aaacaggagg gagcacattg gagttacgct caatcaaaac 2431321 gtttcatacg attgtaaaat ttggaagctt ctataaagct gcagaaatac tcaactactc 2431381 gcagccgacg atatcgatgc gtatgaagca attggagcag gatttaggcg tactgctgtt 2431441 tgaaagagga aaaagcctgc agttgacaaa agcagggaag cttttttatg aacgaacagg 2431501 agatcttttg atgcaatacg aggcgcttaa acacaacctc tccgacttaa aggaagaaga 2431561 ggcaggcatt atcaacatag gggtttcaga gccaaccgcc agtctgatat tccccgagat 2431621 tttaaaggat ttcttaatgg attacccaaa gataacggtt aatatcaagg ttgatgacgc 2431681 caatacctgc agtcaaaagc tcttagacgg gacgattgat tttgcagtct gcggcgagcc 2431741 ggagctgatt cttgaaaatt actaccatcc atttttttat gacacattaa atgtgattgt 2431801 atctgatcaa catccgctcg ctgagaagaa ggctgtccat ttgtctgatt tagcagaaga 2431861 gcgcttcata tttacgcccg ccaattgccc cattcgctta caaattgaac agcatttaca 2431921 tagagaactc gggaatcgct acaaaaaaat ggagctcaca agcagcatgt cacatgaata 2431981 ttacgtacgt gaaaacatcg gaatttcaat ctttaccagc accgcacatt ctaaaccgtt 2432041 caacggcact aaagtcattc caattctgaa cctggatatc accccgccca tagggctgtt 2432101 gacaaatcaa aaagaagttc attttgaccg cgccacgaag gacttgatcg cccggataac 2432161 caaacgtttt cagcagcgca gcaaagaatt ggaaggaacc tctgataaga ccattacagg 2432221 ataactgaaa aaataaaaac cacctcctga ttcatcagga gatggtttca cggtttaaag 2432281 ctcgatcgtc tcaccgaccg acatgacttt gccgactccg cccggcaggc tgtcagcgaa 2432341 tgcttctggg tcttgttcga tgaccgggaa tgtattgtaa tgcaccggca cgacctgttt 2432401 tgcgcgcagc cattcagcag caagcttggc gtcttcaggc cccattgtaa agttatcgcc 2432461 aatcggaagg aaagcaaggt cgatatgatt caattcgcca atgagtttca tatcagagaa 2432521 aagtgccgta tcgcccgcgt ggaaaatcgt tttatcttct acagtcagca aaataccggc 2432581 aggcatgcct gtgtaagtga tcgttttgtt ttcttcatct gtgatggctg atccatgaaa 2432641 ggcctgtgtg agcttcactt ttccaaaatc gaactggcgg gagccgccaa tatgcattgg 2432701 atgaacattc aagcctttcc agcctaagta cacagcgagc tcgttcgggg ctataaccag 2432761 cgcgttattt tgcttggcga tttgttcagt atcaccgaca tggtcattgt ggccgtgcgt 2432821 tagtaagatg acatccgctt ttacatcctc cggctttata tccgttaatg aattccctgt 2432881 taaaaacgga tcaaaaataa tatgatggtc cttcgtttcc actgtgatta cagaatgtcc 2432941 gtgatatgtc actttcattt ctttcacctc gtcacatgat tttgtttttt ttattttccc 2433001 tttttaaaaa gctgaaaaac ttatgttgtt tgattcttgt taatgacatt gaggcctccg 2433061 gtggcttcaa tgacagtccc tgtcacaagg tctgagttct cctcacacaa gaaagcgata 2433121 atcctggcaa tatcctcgcc tgtaccggat cttcctatcg gcgttttttc tttgccgatt 2433181 cgcattctgg cttcctctat cgatgcttct ttcatgtcgc cgacaatgtc tcctgggcaa 2433241 accatgttgg cggttatgcc gaattcggct tcttcaatgg caattgtctt cgtcaaagaa 2433301 gccaagccca ctttcgcagc gccaaatgcc gatcggtgaa gccagccggg cgcgtgagcc 2433361 gcaccttgga atccgtacgt aataatgcgt ccaaattgct gttttctcat aataggaata 2433421 accgctttga ataaatgaaa gacggcgctt aaatttcctt ccagcatgcc ataccattca 2433481 tcatcagtat aatcggctaa ctttttacgt tcaaatatgt atggtccagc gttgttaatc 2433541 aaaaagtcga tccttccgaa gcggtttaag gcagcctctg caatacgcag cagatcttct 2433601 tttttggtga catcaccttt tacaaattgc agccggtcaa gacaatcggg acaggcttcc 2433661 ttcaggcggc tgactgcctc ctcatcctgt ctgtaattga ctgttactga ataccccttt 2433721 gcaagcaacg tttcagtcac tttgcggcct aaacccttcg aaccggcagt aattaaagca 2433781 tgtcgcacat gaatacctcc caaagcaacg tcgccgcttt caataaagtg tttcttcttc 2433841 tactttacta taaaaggctt gcaatatcac tttttacact ttggcataca aaaaaagctg 2433901 cctgtacaga cagcttattc tgcaggagat gaagactcct gatcaggcat atcgacataa 2433961 ccgctttgat atgcttctga aatgagcctt gttgtctcct ggctttcttg ttcatcataa 2434021 atatagcgtt ccggttcttt tttcatcatt ctgcctccca tcattataga ggtaggttgg 2434081 ctataatgac gggattttat gaaggaaatt ttaacaaact cctgctgcca cgcaagcttt 2434141 cgctttttca agcgcctgtt ccacctgttt gaatccggtg cccccggcgc tcattctttt 2434201 ttcaactgcg tagtaagggt ctaacacagt gtaaatatct tcttcaaata gtgtgctcgc 2434261 ctgctgaaac tcgccaaacg gcatatcgct taaatagatc cctctttcga tgcatgtgta 2434321 cacaagtttc ccgaccactt catgcgcttc tctgaacggc attccttttt tagctaaata 2434381 atcggccagt tccgtcgcgt ttgaaaagtc ttgttttgtt gcttgcttca tgacgtcttt 2434441 gtttacagtc attgtttgga tcatgcctgt gaagatttgc aggctgccct ccaccgtttt 2434501 caccgtgtca aacatgccct ctttgtcttc ctgcagatct ttgttgtaag cgagcggaag 2434561 tcctttcatg atcgtaaaca gccccatcat atcgccgtat acgcgtcctg ttttgccgcg 2434621 gatcagctcc gccatatcag ggtttttctt ttgcggcatc atgctgcttc ctgttgcgta 2434681 cgtatcgtca agctcgatga atttaaactc ctgcgagcac cataaaatga tttcttcaga 2434741 gaaacgggat aggtgcatca tcagcatact gctgttgctt aaaaactcca aaatgaagtc 2434801 tctgtcgctg acgccgtcca agctgttttc ataaatggca tcaaagccga gcagttccgc 2434861 tgaataatca cggtcaattg ggaaggttgt tcccgcgagc gccccgcagc cgagcggaga 2434921 tttgttaatc cgcttcattg aatcctgaaa acgctccttg tcgcgctcaa gcatccagaa 2434981 atacgcaagc agatggtgag cgaatgaaat cggctgggcg cgctgcaaat gtgtgtagcc 2435041 cggcagaatc gtttcaacgt tcgcttccgc cttttcaatc agcgcacttt ggaatgcctc 2435101 aatcagctcg atgatgtggc cgacatgatt cttcaagtat aaatgcatgt cagtcgccac 2435161 ctggtcattc cggcttctgc cggtatgcag cttgccgcca agaggaccga tttcgtcaat 2435221 gagcattttc tcaatgttca aatgaatatc ctcataatcg actgagaatt ccaatgctcc 2435281 ctcctctgct ttttgcaaaa gggtattcag gccctctcgg attttcaact cttcttctgc 2435341 tgtcagaata ccgcattttt tcagcatggc agcatgtgcg agagaccctg taatgtcttc 2435401 agcaactaaa ttttggtcaa atgatatgga cgcgccgaac tcgtcgaccc atttttccgg 2435461 tgttttttga aatcggcctc cccaaagctt cttcatgctt taatctgctc cttctttttc 2435521 acgatgctgt tcacttttgt cggaagtccc caaagctcga taaatccgat tgctgcatgg 2435581 tgatcaaatg catcgtcttt tgtatatgtt gcaagttttt catcatatag agagtattcc 2435641 gatttacgtc cttctacaat tgcatggcct ttaaacagct tcacgcggac aatgcctgtg 2435701 acatgctttt gcgtttcttt taagaaagcg tgcagcgcgt cttttaacgg tgagaaccat 2435761 aagccgttgt aaatgatttc tgacattttt tgctcgatga tcggtttaaa gtgggctacc 2435821 tctttcacca gtgtcaaatc ttctaattct ttatgcgctt tgatcagtgt catcgcacca 2435881 gggcattcgt atacttcccg ggatttaatg ccgacgaggc ggttttccac gtggtcgata 2435941 cgtccgacac cgtgcgcgcc cgccatttca ttcagcttca agatcagctc agaaagcgag 2436001 taggaaacac cgtcaatgga gacaggcacg ccctgttcaa atgcaatttc aatcacttcc 2436061 ggcgtgtccg gcgttttttc cagcggagct gttaaatcgt atgcaccttc tggcggcgcc 2436121 gcccatggat cttctaaaat gccgcactca ttggcgcgtc cccagaggtt ttggtcgata 2436181 gaatacgggc tgtcaagatt gatcggaatc ggaatgccgc ggctagccgc atattcaatt 2436241 tcttcttcac gtgaccactg ccattcgcga accggcgcga tgacttctag gtcagggttt 2436301 aatgatttaa tggagacttc gaaacgaacc tggtcatttc ctttccctgt gcatccgtgg 2436361 gcaatcgcct gtgcatcttc tttttccgca atttcaacca gttttttcgc gatcagcggt 2436421 cgagataatg ccgaaacaag cgggtatttt ccttcataca ttgtgtgggc ctgcaaagag 2436481 ataagcgcgt aatcctgtgc aaattcttct tttgcatcga tcacgtagga gtttgtcgcg 2436541 ccgacttcaa gcgctttctg ctgaacaaat gccaaatctt tgccctcacc gacatccagg 2436601 cagcaggcga ttacattata tccttgctcc tgaagccatt ttattgcgac ggaagtatca 2436661 agacctcctg agtatgctaa tacgactttt ttctgttctg acatgataaa aatcccctct 2436721 caaccgtgtt tctattttgt ataaaaataa attatattta ataaaaatac attttgtatg 2436781 tatacacttt aacaagtacg tttcgttttt tcaagccttt tataaaaaaa acttcaccta 2436841 aatttcaggt gaagtttcat agtatttatt catttacttg tcttttctga tttctctgac 2436901 cacatgcgca agttcgggaa taatcagctt attcattgcc agctttactg cgccgcttga 2436961 gcctggcgtt gagaaaacag cggtatgctg aatgacgccg gcagttgctc tcgacatgat 2437021 tgcggcagag ccgatatcct ctgtataact cagcatcctg aatatttctc caaagccggg 2437081 cagttctttc gaaaacagcg gcgttatggc ttcaattgtg acatcccgat ctgctatgcc 2437141 tgtccctccg tttaagagta ccgcgtctgt ctgttcatcc atgcagcccg caagcactga 2437201 ccgttgcaaa gcatcctttt cgtcttttac aatttcatat gcggcaatat gatgaccggc 2437261 ttcttctaaa aatgagatca tcagcttgcc gcttttatcg gtttcatctg tcctcgtgtc 2437321 actgacagta atcactttgc accgaacgat atcgggagct tcttgtttat gctcttgaac 2437381 gctcattggc ccacctcttt tatgttttct gtctgtcact atcatgcatc aacaaaaaag 2437441 cacattcaag agaatgtgct ttcatgcgat ttattttgct aaacgaacaa cgtcgcgcgc 2437501 aatcatgact tcttcatcag tcgggatgat catgactttt actggagaat gcggatagct 2437561 gatgaaagct tcctcgccgc gcacgttatt aagcgcaggg tcccagtata cgcccatgaa 2437621 ttctaaaccg cgaagaacgc gttctctgac ttccacactg ttttcaccga taccggcagt 2437681 aaagatgatc gcatctacac cgctcattct tgcagcgtaa gaaccgatgt atttgtggat 2437741 tctgcttgcg aatacttcaa gagccgtttc cgcgcgctca tttccttctt tcgtagcttc 2437801 aacgatgtca cgaagatcgc ttgagaaacc ggaaatgccg agcagtccgc tttttttgtt 2437861 taatgtattc agtacttcgt cagccgtttg gcctgttttc tccatgatgt atgggatcag 2437921 ggcagggtcg atgtttccag agcgtgtgcc cattgctaca ccggcaagcg gcgtaaagcc 2437981 catggatgtg tcaatagatt ttccgccttc aacagcggca atacttgctc cgtttccaag 2438041 gtggcaggaa atcaggcgca agtcttttaa cggacggccg agaagctctg ccgcacgctc 2438101 agttacatat ttatgtgaag tgccgtggaa gccgtattta cggatgccga atttttcata 2438161 gtattcatac ggcaagctgt aaaggtaaga ctgctcaggc attgtttggt ggaatgctgt 2438221 atcaaataca gctaccgcag gaacatttgg aagcacttct ttgaacgctt taattccaac 2438281 gatatttgcc ggattgtgaa gcggtgccaa ttcagaaata tcttcgattt ccttaatggt 2438341 ttcatccgtt aataaaacag aatcgctgaa tttttctccg ccgtgaacga cacgatggcc 2438401 aattccgtca atttcattca agtctttaat aatgccgaat tccgttaact tattcagcag 2438461 cattttaaca gctaccgcat gatctggaat atcagttact tctgtatttt tttcgccgtt 2438521 cacagaaatt gtgaatacgc tgtcggcgat accgattcgt tcaactaaac ccttcgttaa 2438581 aacggtttct gaaggcattt cgaaaagctg aaatttcaaa gacgagcttc ctgcgttaat 2438641 tgcaataatt ttggacatga ttgacgctcc tttatactct gtatcaacaa cttcgttttt 2438701 cgtacttttt tcccggtgaa tatcaacatc ttctccgaaa aatatctgac ttttccattt 2438761 aaacattgtc atgtcggctt ttcaagtcaa cttgcgtatt gataacgctt acaataagaa 2438821 gtcgttattt tcagacacat tcactatagg ttttgtattg atgaacgctt acaatttgcg 2438881 gtttttccct ctgtattttg tgtttcaaag ctggattcaa ttcgtcaagt ccggtcttca 2438941 aaagcataaa taaaagcagc ttaggcatcg acctcatacg gctgtctaag ctgcttttaa 2439001 aacacttact tttctttttt aaaccattca tcaaattgag ccatcatatc aagcatcgcc 2439061 ttttgattgg agaaagacgg aagattcgca agcagaattt gccccggcgc tttcgtattc 2439121 tctccttgtt tctgaagcac aaggatgctt ttggcatgag cttcgtcttt aaaaatagat 2439181 tttggcagct gcaacagtgc gttgatatga accttatctt tgaaaaactg tttcagcttg 2439241 ccgctttggg agctctcaaa caaatgattc ggaatcataa aaaataagta gccgcccggt 2439301 ttggtatgct tgacgctctg ttcaataaac agatgatgag cgaaggaatg gccttcgtca 2439361 gctttgagct caaacgcttc tgctccttcg tcattcggat aatagccgac tggcagatca 2439421 caaatgaccg tgtcaactgg atcgataaac aacggctcaa ggctgtcctg gtggaaaagc 2439481 tcaagctctt ttttcagaag gttcgcttgg gcataggcga tcttcaagag cacatcatca 2439541 atttcaatgc caaagctgtt tgccgttttt tcagacagct ggttcagcac ggtaaacaga 2439601 aggttcccag ttcccagggc tggatcaaga atggtcagtt cctttttgtc cgccataaat 2439661 ttattcacca aatagctgat gaaaagcccg atcgtatccg gcgtcatttg tctgtttgga 2439721 tgcgagatat ctttcattcc tttaaggacg gcaagctgaa aagccttgcg tacccactca 2439781 tgctcatacg tgccgaattc cgctttttca agcagagcct gaagttgttt ggttttctga 2439841 tcagcaggca gtttcagctg atccgttttt tcaagaaaat acatttctcc tgcttcggcc 2439901 agcgcctcta tatatgaaat ctgcaattca ttctttatca taatcgcggc ttcgtttaac 2439961 agctcataca ccgcacctac atggtctttt tgcatattgt gttcctcctt gccatgaaaa 2440021 aagctccggc ggcagcctgg agcttttttc cctgcttact ttactaatgc cttagcagcc 2440081 tcaattggct tttcatagtt cgggtggttt gttgcttcgc ttacatattc agcgtaaacg 2440141 acttttccgt tctcatcaag gacaaatacg gaacgcgcaa gcagacgaag ttctttaata 2440201 tacacaccga acgcttcgcc aaatgacata tctctgtggt cagacagtgt ttccactttg 2440261 tcaattccgt tagcgccgca ccagcgcgct tgcgcgaatg gaaggtctgc actgattgtg 2440321 tagacgttga catctccaag ctttgcagct tcttcgttaa aacggcgtgt ttgtgcatca 2440381 caaacacctg tatcaattga agggataaca gaaataatcg ttacctttcc tttcatgtca 2440441 gctaacgatt tttcttcaag gctgttagtc agcactgtga aatcaggagc ttgatctcct 2440501 accttcactt cttgtccgac aagtgtaacc ggaccgcctt tgaatgtaat ttcagccatt 2440561 ataattcctc ccttttgtat gtatgtctct atcatagtaa agtttcctgc aaactgcaaa 2440621 gtttatgcca aaaaaaagtt aactgcggcc agcgcagtta accttttttt aataattcat 2440681 attgttcatt tggttttgat tttggccttg gctttggttt ttgttatttt tcttgaacat 2440741 ttgctggatg cgctcgagtg tttgaggggc tgcgtctaaa attttctcta ttaaatgggt 2440801 attttcatct aaatgaagca ttctgatgcc tgtcgatccg acaattaaaa acgcgatcgg 2440861 cgtaatggac acaccgcccc cgcttccgcc tccgaaagga agtttctgtt ctcttgtctc 2440921 atcgtcttcc gatttctttt cggccggctt tccgccaaac tcgcttccgc ctgcggcgaa 2440981 tccgaatcca actttagaaa cagttaaaat cacacttcca tcaggcgttt ccactggatc 2441041 tccgatgatg gtgttaacat caatcatttc cttcaagttt tccattgcgg ttttcattaa 2441101 accttggatg ggatggtctg ccatatacgc ttcctcctta aactgatgaa tcattctttg 2441161 aagtcattct agccgacgga ttcttcttta atacggatag ctcccgtccg tatttgacga 2441221 atttgaaagc tgcaagcata gcatgtccaa agcgaaaaaa gaatatacac tgaaaatggg 2441281 tcttggaaac agggacttga aacgacggga tcacctcata gacaggttta ttcacaaagt 2441341 ccaggtggtc gtagagcatt gctgcgatac cgcccttcac gccccataca gcaccggtta 2441401 acacacctgt cactgccgcg tcctgaattc cgattactgt aacccattct agttttgtga 2441461 tatgtaaatg cgcgagaaaa gacgcgctga ttttccgcag tctggtgacc tgatgcaaaa 2441521 gcatttcgat tttattaatg ctttgctgca catcgttttg tgtaattttt ttctttccgc 2441581 tgcttttttt cattttggat tcagtttttt gtttgatatc cactgttccg tcttctttgt 2441641 tcaccttaat cgccgggatt gtttttttga tccttataag gccaaacagc gccgtaatct 2441701 tcaaggtcaa tttgtcatta tcatcggcat gaagatactc cagcgcgaca tggattttca 2441761 ttctgagaag cagtacgatc cctatgagaa taagaatggc tgtcagtaca tacaccatat 2441821 tcttcacttc ctctaggagc attatcgcca attcctaaaa aaataaaccc ggacggaagt 2441881 ccgggttatc ggttatttgc ggtataattt ttcatgcacc acggtggtat ccgcgatgta 2441941 atcatgaatc ccttgttttg taggtgaaaa ggcaacaacg atatataaaa tccaaatctt 2442001 atcaatatac cgtccaacca cttcacgaaa aatcactgta ctccatgtca gcttgctatc 2442061 ttgcttcaca gaaaccactt tgaggccgaa caccatttta ccaagcgtct gcctgaagta 2442121 ttttgtcatg agtgcgaaat aggcaagata cacaataagc gttgtcacac tgtaggccga 2442181 gaaggtaaac atgccggatg ttttcggcag atccaatacg gtaaagaggg gagaaacgag 2442241 caaatggttt aatccccata tcacgagcca atcaagcagg aaagcccaga aacgaaccca 2442301 aaagccagca taggcatgtg tcagcagctc cgcttcttgc gggcctttga tgtcattgcg 2442361 ctctaactct tcatatgtcg cgtccattat tgttccctcc tacttcgcat agagatacat 2442421 cattctcggc gaaccggatt gcgatagaat ttctctcata ttcaaaaaat caatttcact 2442481 tttaaacatt ttgttcgcgc ccatggaaaa cagtgagcct aatccgaagc tttcctcata 2442541 agaaatgaca gaggcgtttt tcaaatcctt gtgatccttt ttcatggccg taatggtatc 2442601 gtcataaaaa ccaagctcat caacgaggtt cagttttttc gcctgccgtc cgtcatacac 2442661 gcggccgtcc gcaattttct ttacctctgc tttcggcatg ccgcgccctt ttgaaatgac 2442721 atcaacaaag ccttcatacg aattatcaac catcgattgc atgatgtttt tttcttcttt 2442781 cgtcatctca cgggaaggag acataatgtc cttatgggcc ccgctcttaa tcgtttcaaa 2442841 agaaatgcca agcttgtcgg caagctttga ataattgacg ctttccataa tgacgccgag 2442901 tgacccggtc agggtttccg gtgtcgcaaa aatcttatca gccgctgttg agatgtaata 2442961 gcctcctgat gctgccatcg aacccattga cacgtaaatc ggttttttcg tttctttctt 2443021 gatttcttcc agtttcttat gtatttcagc actttcatac actccgccac ccggagaatt 2443081 caccttcaga acgatacctt tgaccgtctt gtcatctttt gcgcgctcaa ggttttttaa 2443141 gaacgttctg tggttatatc cgtctgcacc aagcagactg cttgagtccc cattatcctg 2443201 aatggtgccg ctgacctcta atacggcaat tttacttgag ggactgccgt tttccagcgt 2443261 cttctcctgc gattcatccg tcagtgatgt gagatccgtt tgagcgcctt tgacgctttc 2443321 aaagaaactc atagagatgc tgacgataat agacacgccg aaaatcccca gagcaatcac 2443381 taatgcaatc catctttttg cattcatttt ttctcctcct ttttcctaaa ctctctcatt 2443441 atacgattca atatgaaaaa tgtttcactt catgagaaag ctccggctta acgggctgcc 2443501 ggcaaacgtg gtacacttat ggccaaaggt attttatcac aaatactgga tggcagaaaa 2443561 acttaaatat gacagcaaag gggaaatggg atatgaccga tcaacgccgt aatgtttatt 2443621 tttttcacaa acaggatcag gaaacgaacg aacaagcccg ctcgttaaca caattagcgg 2443681 aagagcatgg atttaccgtt gtgaaccagc actcagacgc caatattatc gctagcattg 2443741 gcggggacgg cacatttttg caggcagtca gaaagacgaa ttttcgtgac gactgcttgt 2443801 acgtcggcat taccaaaaag gggaaagctc atttatattg cgactttcat agtgatgagc 2443861 gagaaaaaat ggtcgatgca atgacgtttg aacaaattga agtgagaaaa tacccgctga 2443921 ttgaagtgac agtggatcaa gccagtcctt ttcactgctt aaacgaggta tccatccgct 2443981 caagcatcat caaaaccttt gtgatggacg tgctgattga cgatctgcac tttgaaacgt 2444041 ttagaggtga cggaatgatt atctcaacgc ctacagggag caccgcctat aacaagtctg 2444101 ttgcaggagc tgttgttgat ccattgcttc catgcatgca ggtatcagag cttgcatccc 2444161 ttaacaataa tacctaccgg acactcggct cgccatttgt cctcagctct gaccgaaagc 2444221 tgacccttcg tgtggtgcag gacggcaacg aacacccaat catcggcttg gacaatgaag 2444281 cactcagcac gagaaatgtg aaaacgatcg aaatcaaact gtctaataag aaaatcaaaa 2444341 cagtcaaact aaaggacaat tcattttggg aaaaagtgaa gcgtactttt ttatagaaaa 2444401 taaaaggaca ggctgctgcc tgtcctttta tgatttctca tatacaatct ggccgttaat 2444461 cacggttttt ttaatctcta aaagatgaag ctgtgcgggg tcaatggcaa acggatcacc 2444521 actgagaact gtaaaatccg cgtcatagcc ttccgcaatt tttccgcgtg acttctcttt 2444581 ataaatgata ccggcgctac cttctgtata aagctttatc gcttcatata caggtaaaca 2444641 ttcactttca ttatagcttg gcccgttttg ctcatgactg cttttccgga ggaccgcgga 2444701 ctggatccct agaagcgggt caacaggctc aatcggggcg tctgaaccgc ccgcgcataa 2444761 aatgccttta gatatgaggg ttttccaggc aaatgcagtc ttcatccggt cttttccgag 2444821 acggtcaatg acccacggaa agtcgcttgc aacgaagtgc ggctgaaggt caagtgcgat 2444881 cggcatgcgt gctgctctct cgattaattc gttatcaagc acttgagcat gaataagccg 2444941 atcatgccgg ccgtttttgg gcggatgctt ttctattgcg ttcagcactt tttcaaaagc 2445001 aagatcgccg attgcatgaa cagcaacctc catccctttt tctctcgctt tgcgaatgag 2445061 ccggccaagg gtttcgtcat cgtgaacctg aacaccattt gttgatggat catcctgata 2445121 tggttctttc aataaagccg ttctcccgcc aagcgccccg tccgcaaaga ttttcatagc 2445181 accgaactcc acatacgggc cggacagctt ctccagctgc tcccatcgat cgacagcttc 2445241 atgatgaacg agcaaatggc agcgaaacgg atactttccg ccagcggcag ctttctcata 2445301 agctttcatc ggcaccgaaa catcaccata ataggacaag tcttccgaat gaccgcccgt 2445361 caggcctttt gtccagcaat cctttattgc agccgttaat gcctcatcaa catagtgctg 2445421 ggagactggc gggacagcct tcagaatcaa atcctgcgcc ttatcaaaca ggagtccggt 2445481 cggctcgcca tttgcatctt ttacgatgac tccgccgtca ggatcaggag tatttcttga 2445541 aattcccgct gcttgaagag ccgcagaatt gacagctatt gcatgccggc atatacgctt 2445601 gagcaagacg ggcctgtcag gaaacaggcg atcaagatca tgcttagtca agtagtcagg 2445661 tgtctcaaac tgattttcat tccagccttc tccaatgagc caatcgtttt taggaagctg 2445721 ccgctctctt tccttcgcag cctgtaaaat tgaatctttc gacgtcagtg cggacagatc 2445781 gagctgaagc tgtttctcac cgtggccgat caaatgtaga tggctgtcaa caaaaccggg 2445841 gaacatcact gctccgttca ggctgatttc ttctgtttcc ggcgacccgt acttttcctt 2445901 caaacgttca tagctgccgg tgccttttat aacaccatcc tcaacataaa ctgcctcagt 2445961 ccgatcgcct tcttcgagca tcgtataaat gaaaccgccg tgccatatcg ccttcattca 2446021 cgttcactct ctttctttac gcctttttat tggctttgag ctgttcttca cgttttctta 2446081 attccactcg tctgattttt gcagaagccg ttttcggcag gctttccaca aattcaattt 2446141 ctctaggata tttgtatgga gcggtaatcg tcttcacatg gttttgcagc attttgacaa 2446201 gctcatcact gcgtttttca tgattttgca ggacaacata tgcctttacg atggagcctc 2446261 tgatttcatc agggcttgcg acaacagcac attcttttac ttctgggtgc ttaacaagcg 2446321 cgtcttccac ctcgaaaggc ccgatcgtat agccggagct gataataata tcgtcatttc 2446381 ggctttcaaa ccagaagtaa ccttcctcat cttttcttgc tctgtctccc gttaggaaat 2446441 aatcgccgcg aatttgtgtt ttcattcttt ccggatcttt aaaatactct ttaaagagcg 2446501 caggcgtact gaggtgaaca gcgatatcgc caacctcacc aggtttgcag atttcaccgt 2446561 cttcatttat gatctccacc tgatttcccg gtgtcggttt tcccatgctt cccggtttaa 2446621 taggcgtatc tttcaaaaca ccaaccaaaa gcgtgctttc tgtttggcca tatccgtccc 2446681 gtaccttaat gccaaagtgc ttttggaaaa catcaatgac ttcacggttg agcggctcac 2446741 ctgcggaaac agcgctgtgc agggcagaaa gatcaaagcg tttcaagcct tcaaccttcg 2446801 ccattaagcg gtattctgtc ggagtgcagc agaaaacatt gattttgtag cgatttaaaa 2446861 gctctagata tttttctgct ttgaatctgc cgtggtacac aaaaccggtt gctccgctgc 2446921 caagcaccgc taaaaacgga ctccataccc acttttgcca gccaggggca gcagttgccc 2446981 agacgatatc cttttcagaa atgtcaagcc aagcgccggc agaagttttt aaatgagcaa 2447041 atgcccatcc atgtgtatgt acaacacctt tcggctgacc tgttgtcccg gatgtataag 2447101 ataagaaagc catatcatct cttgttgtgt cagctgtttt aaattggctt ccgtccgctt 2447161 caattgataa gaggtttttc cagccggcat cattttcacc aatagacagt gtaatcagtt 2447221 tgtcagccgt actgacatcc cggaaagcgc caataaattc ggagtagacg atagcgcctt 2447281 ttacctctgc atgttcaatc cggtattcaa gatctttcgc gcgaagcatt tcggagcacg 2447341 gaatgacaac cattcctgat ttcaggatag ccaaataaac agcataggct tcaagcaccc 2447401 gcggaaccat tacaatcagc ttgtctccct ttttaaatcc aagatcagct aaggccgctc 2447461 cgattttatt tgtttcttcc atcagctttt catacgacca agattcttgc ttgcccgact 2447521 cgtcctccca aagaagagcg gttttttgtc cagcagcact gaacttttcc atttcattca 2447581 ctaaattata ttgcacaggg gcaattaaat cttcacgttt taacacgaac aactcctcac 2447641 tttctccacc cattatacat aaatacaggc tctttccgta aggatatgcc taaaagcaac 2447701 ctctgtaaac atagatttta taggccgctg gtcctttttt atatgtaaaa aatgaaaaag 2447761 agtggggata cccccactcc taagccatta tgtgaaattg taaattagaa ttgtcctccg 2447821 cccatgtttt gttgagcaaa agatacaaga cgttttgtga tctctcctcc aacagaaccg 2447881 ttagcgcgag aagttgtgtc tgctccaagg tttacaccga attcagaagc gatttctaat 2447941 ttcatttggt cgatcgcttg agcagctcct ggtactaaaa ggttgttgct gttacctgag 2448001 ttattgttag ccatgtgtct cacctccttg tgagtataga atgtgtcaaa acacatggct 2448061 tcattcagaa aaactttggt aattgtatac aggagctgaa aattgattta aaagagttca 2448121 gcgaatttat cgttagcttc ttgttcgcta taaagggtca ttgtctcaat gttatctacc 2448181 gcttcttgaa tatacggctc gaaatcaaca aagctttcaa agtgttcaat tttctctttt 2448241 ttagggcgtg ttttcgggct tggcggtgta aagatcgtgc agcagtcttc aaacggctga 2448301 atacttgtct catatgtgcc aatttcccgt gatttttcga tgatttctgt tttgtccatg 2448361 gcgattagcg gacgcaaaat cggtgttgac gtcaccgcat taattgcata catgctttca 2448421 agcgtttggc tcgctacctg accgaggctt tctcccgtaa taatggcaag cccgtttctc 2448481 ttttctctga ttctgtcggc tatctgaagc atgaggcggc gggttgccgt cattgtgtaa 2448541 ttttcaggaa tttgtttttg gatgagctct tgcgtttttg taaatggaac aatatgaagt 2448601 gtcatgcttc ccccaaaacg ggacagacat ttcgccagat ccattacctt ttgctttgcg 2448661 cgctcgcttg tgtatggcgg gctgaagaaa tgaacagctt ctaccgacaa tccccgtttc 2448721 atcgcataaa aaccggccac agggctgtca aaaccgccag aaagcatcag catcgctttt 2448781 cctgctgaac caactggcag cccgcctgca cctttttcat cacgaattgt caaaaatgtt 2448841 gcttcttccc tgatttcgat tctgagcggg atgtctgggt tgcgaacatc gaccgtcaat 2448901 ccttctgtat ttcgcaaaat atggccgccg atttcagcgt tcatctggtt tgtatctaat 2448961 tcaaattgct tatacgctct ctttgtcgcg actttaaacg tatcacctgg tttatactga 2449021 tctttgatag cctttagtgc ggttgcctta atatcatcaa ggcggctgtc acacttaatt 2449081 gccaggctga agctttgaat cccaaacact tgctttaaat gaggaaaaag agcctcagga 2449141 tcctctccat ttaatgtaat cgtcatacga tccctgttgg aaaagtattt taaattcgga 2449201 tagtctttca aaacgagtct gatgttttgt tttaagcgct caataaagct ttttctgttt 2449261 ttgcctttgg tcgaaatttc cccaaaacga attaatatat gatcgtaatt catgttctac 2449321 ctcatcattt cccttaattt tttgatgcca ggacgaagcg cgttcataaa cggttctgcc 2449381 acatcgcttg tctggctgta atttaaactg attctgatgc tgcttccggc aatctgctct 2449441 cctttgccca tctctaagag aaccttgctg ggcttatgtt cttttgccga gcaagccgat 2449501 gttgtggaga cgaatatatc ctgttcctca agcatgtgta aaagcacttc cgctttaatc 2449561 cccggtacag agaaattaat aatgtgcggc gcgctattca tttgaggcgt gttgataacg 2449621 acgccctcaa tttcactcag cctattcata aacaattcct ttacggcagt catcgtgtca 2449681 agccgtgtgt caaaatcagc agaggccaga ttaatggcct tggcaagcga aaccgcacca 2449741 gcagtatgtt ctgttccggc ccgtatgcct ttttgctgag agcctcccgt tatgagcgga 2449801 ataaggcgtg ttccttcttt tacaataagt gcgcctgtcc cctttaggcc gtgaaattta 2449861 tgccccgaaa ttgaacatag atcaatgccg gccttttcaa ttgccaaggg cactttatag 2449921 atgccctgca cataatcgac gtgaaacaaa atgttcgaat gctctttcag cacttctcct 2449981 gccgcttcaa tcggctgcac ggaaccgact tcattgttca catgcatcat gctgacaagc 2450041 acggtatcgg gacggatggc tgcttttaga tcttcaatag aaacaaatcc gtcttcattc 2450101 acagaaagat aagtgatatc aaacccgaac aactctttca gctgttctaa cgattccgta 2450161 acggatggat gttcaataga agtggcaatg atatgtttgc ctgtttttat ctttgacaaa 2450221 gccgctcctt ttaaagccgc attattggct tctgtggcgc ctgacgtaaa tacaatatca 2450281 tattttttta ggcctaagga ccttttgatt tgatttttgg ctgcttgaag cagctgttcc 2450341 gtttcggctc catatcggtg caaagatgaa ggattgccaa agtatcggct gctcgtctgt 2450401 tcatatacgt tcaagacttc atcgtaaggc ttcgtcgttg aactattatc taaatatatc 2450461 atctttttta ctcctttatg aaagcggtac aaggtatgat atttatgtta ccataacaaa 2450521 atttaataga aaattacgaa aaactagtat tgacttctaa tttttttacc atataataag 2450581 atttgttcgt ttcgtcatat tatctgacaa ttaattgaca gaatatttta acataattat 2450641 taggaggatt tttttcatga aacactcact gcctgtcaaa gataccatta ttattggttt 2450701 catgctattt gcgttattct ttggagcagg aaatatgatt tatccgccgg aacttggaca 2450761 agcagccgga cacaacgtct ggaaggccat cggcggattt ttactgacag gggtaggcct 2450821 gccgcttctc ggcattatcg ccatcgcatt aaccggtaag gacgctaaag gccttgctga 2450881 caaagcgcac cctgttttcg gcacaatctt tactgtcgtg ctttatttat caatcggacc 2450941 attattcgcc atcccgagaa caggaactgt ttcatatgaa attggcgctg ttccgttttt 2451001 gactggtgta ccagaaagac tttctttatt aatatttaca cttatctttt tcggcgttac 2451061 gtactattta gcgttaaacc catctaaggt tgtggatcga gtcggaaaaa ttctgactcc 2451121 catcaaattc acaattattt taatcattgt tctcaaagcc atcttcacgc cgatgggcgg 2451181 attgggcgcc gtgacagaag catataaagg aacaccggtt tttaaaggat ttttagaagg 2451241 ctataaaaca atggacgcac ttgcttcaat tgtatttggc gttgtcgttg taaatgctgt 2451301 aaaaagcaaa ggcgttacac agtctaaagc tcttgctgca gcctgcatta aagcaggtgt 2451361 gattgccgct ttaggcctga ctttcattta tgtatccctt gcttatttag gtgcaacaag 2451421 cacaaatgcc attggtcctg ttggtgaagg agctaaaatt ttatctgcgt cttcccatta 2451481 tttattcggt tcattgggca acatcgtact cggagcagcg attacagtcg catgtttaac 2451541 aacaagcatc ggccttgtca catcttgcgg ccaatatttt tcaaaactta ttccggcatt 2451601 atcatataaa attgtcgtta cgattgtcac gttattcagc ttgatcattg cgaatttcgg 2451661 actcgcgcaa attatcgcgt tttctgttcc tattttatca gctatctatc cgcttgccat 2451721 tgtcattatc gttctttcct tcatcgataa gatctttaaa gaaagacgcg aagtgtacat 2451781 cgcatgcttg atcggtacag gacttttcag tattttagac ggtatcaaag cagccggttt 2451841 ttcacttgga tctttagatg tgtttctaaa tgcgaatctt cctctttaca gcctcggcat 2451901 cggctgggtg cttccaggaa tcgtcggagc ggttatcggc tatgtgctga ccttattcat 2451961 cggaccatcc aaacagctta atgaaataag ttaatgtcac agaacgcctg cgttattgcg 2452021 caggcgtttt gtaataaaaa aagagcctgc tcattacact gcgggctctt tttcatggtc 2452081 gtgattatct aagcggatat gtcagctttg attttttcaa ctgcacctgg cgcagccttt 2452141 tctacagcgg cagcggcaat ttcataagag tcgtcataat caaaagcata aaaacgtctt 2452201 tccgcttctt tcagctgttc agataaaata tgattctggc ttctgaaccg gtttccgaac 2452261 tgaatgattt tttcaatgag gatgacctgc tcgacaagtt cctctgattc ccggcttgcc 2452321 ctgttgacga tatcttctgc ttgtttcaaa tgggctccgg cttcttccat atttaatgga 2452381 agttcgttta gttgattgac cgtttcttga atatgatgat gcgcgttctc cagcatctct 2452441 tgaatatggc tcggaatgcc tggaatgttg ctagtcttca gcagtcttgc tgtctcagaa 2452501 attgtttttt tcaaattgct gagcgtctcc ctcgcctgaa gctcttcttt tctcagcgct 2452561 tgcagatttt cacgatactc ggcatgctct tttttcactt cttcaatttg cttctctatt 2452621 gaagcaactt cttctactaa aagtgagtag gcgacatgct ctgcatcaag cttatcttta 2452681 acggatgata gcagctttcc aatttcatca aggcgctttt caaaagcctg ctgtttgccg 2452741 agctcaccgg ctgtcagcct gtagctttcc ttcaccagct cagtttccgc tttcgtatgc 2452801 tctttctctt ctttaagctt gtcgtaagca ataatcaatt caggcatttt gcttagtacg 2452861 gattgaccgg cttcaacttc gccctccagc tgctgataaa cagattgaat attttcgtca 2452921 atgagctgca ggattgcgga cgcttcatca atatccagtt cagtcatcag gacatgttcc 2452981 gctcgtttca gctggtttga cagattttct aattccttat caagctggat atgctcaagc 2453041 ttgtaccctt tttctttcat ttcgccatag ccatccttga gctttgcaat ctgtccgggc 2453101 accgtctgtt tacagtcagc taacagcttc ggcacatcat ctatgtatga ctgaagccgt 2453161 tcaagattgc ggtcctgctc aagcagtact tttcgtgcag taatatagtt tccgccttct 2453221 gtttcttctt caaattgttt gatgccgctc caaatttcgt ccagatcctt ttcaaggctg 2453281 tcataaagct ccccgtaaag gtggctgtaa gccagcaggt tttttcgaga tttcgaatag 2453341 cgctccctca cctgttcaat ctcttcacgg ctcttttcct cacttgtgac aagatcgctg 2453401 atttcccgaa gaatcttttc aatgcttgat tcagccgctg tcagcaggtc gtcgatatga 2453461 acgagcactt gattggcctt tttaaaccgg tatttgtctg cattttcctc ggcatcataa 2453521 aggagctctt caactttcgg catgtgggct gtgacaatct catcccattc ttcacgccac 2453581 ttctcaaaga actcttctgt ctgacccgtc atttttaaat gttttatttt agacatttct 2453641 tccacgatcg accgattcag aatttcaatc ttccacgatt ccagccggtc gatttcggcg 2453701 tagatttttt tcctgaaaaa gtagcctgcc gcaaacagcg caagcagtac aattaataat 2453761 ccaatgacaa actccataat gagccccctt gctgtttacc ttaatctgtc agggtgtttt 2453821 atttattcag aaagatttca ggatatgtat tgagaaaaac tgtcgttttc attgttatta 2453881 tgataccatg taacaaacat tttttgacca gaaatcaaaa actttttgtg caaaatcggc 2453941 aggatttgac tattttttca tggggtgaca tcaatgcaaa agcgagacgg acatattcac 2454001 acaccatttt gccctcacgg ctccaatgac acactcagac aatatgcaga agaagcctta 2454061 aaaaaagggt tcgaatcgat tacttttacc gaacacgccc cattgccgcc atcttttacc 2454121 gatcccacgc cgctgaaaga cagcgcgatg gcgcaagctt ctttggaacg ctatattcat 2454181 gaaatttccg gattaaaaaa agaatatcgc ggacagctta gcatacggac agggcttgaa 2454241 gtcgattata tcgctgaatt tgaagacgaa attacattat tcctagacac atacgggcca 2454301 tatttagatg acagcatctt atccgttcat tttttgcgca cagactcttc ctatctatgc 2454361 cttgattatg acgagcatac cttcaaagag ctgatttcag cctgcggaag cattgaagcg 2454421 gtatatgaac aatattaccg gagtatctat tcttccattg tagcatctct cggcgtttat 2454481 aagccaaaaa gagtcggtca catcacactc gtccaaaaat tcatcaagct gtttccatac 2454541 agcatgtcag agcatattcg cggcctcgtt tctctgtgcc tgaatgccat tgaagaaaac 2454601 ggaatggagc tcgacttcaa tacttccggc ttaagaaaaa cttacgctgg cggtatttat 2454661 atcgaggatt ggatgctgaa tgaagcgaag caaaagaaga tcccgcttgt gtttgggtct 2454721 gatgcccatc aagcgggaga tgtcggatat gcgtatgagg cgtttttgga acggtgctag 2454781 ttggtgagcg ccacgtctcc tgtccggaag acgcttctga tccaaatctt gatttcttca 2454841 aaatacattt tataaaaata cggctcgtgc ggctgcatgt agagtacttc tgaaatatat 2454901 tgaggctgga gatagggcat catcaagaga gattttaatt ggagaataaa atgaggcagc 2454961 ggcagcgtta aatattcacg ctgtttttct ccttcctcaa tgatcagctg gaagatatac 2455021 ttttccttca ttagatatgt cgacataatt tccctgatta atgtggagtc aattgtgact 2455081 tcccggtaga caaaacgagt taattgacga tgattatgct gataggataa aatatcgaaa 2455141 accaattgaa gaagctgttc ctgcgtgctt tgagtagaga tattgcttgc cgctgtttca 2455201 agcgttttgc tgtagccttc gtaaaactct gaaactaagt gttccatcaa gcctcctttg 2455261 cctttaaaat agtaggagat gtgcgcaaca tttacatcag ctgactttgc gatttcacgg 2455321 acagacgtgc cagaaaatcc tttttggtta aaaagcatga cagcagattc aataattttg 2455381 tctttggtgc ttactttcat acggctcact ccttcctctt gatactattc aagcagaaag 2455441 ccgctgttcc tgtaagaact tatcgacaaa tgccggcaga aaagccggaa ctttgtttta 2455501 tattatagaa aaagtgaggg ttttccatgt tccatgtcga aaaacaatct ggagataaag 2455561 aaaaagacta tcagcttctg ctaaaacagc tcgaagccat gaccgaagac gaaacagacc 2455621 aaatagctaa ctatgcaaat gcctcagcac tgctgtatca ttcgctgcct gaagtcaact 2455681 gggcgggttt ctattttgcc aaagaagagg atggacagct tgtgttaggt ccgttccaag 2455741 gcctgccggc atgtgttcgg attcctttcg gcagaggggt ttgcggcaca gcgtacgcaa 2455801 acggaaaagt ggaacgtatt gaggatgtaa acgcgtttcc gggacatatc gcctgcgatg 2455861 cagcgtctca atcagaaatt gtgcttccga ttcgtgtaga cggaaaaatt gtcggcgtct 2455921 tggacatcga cagcccagtg aaaaaccgtt tcgacgaaat tgatgaaaaa tacttaactc 2455981 aatttgccga aacgctagaa aaagcgttag cgcagtaata taaaagccca aaactgatat 2456041 cgttttgggc tttttttatt ttattgagtc atgaatcatc aagcggtttt tcccgctccg 2456101 tttcgcgctg tagagcgctt catctgcctc atgcacaagc tctttcagcg acttttttgt 2456161 ttctgtcgtc cagcaggaga taccgcagga aatggttacc tcgggtttcg tattttttct 2456221 gaccgcgtaa accagtcgct cggtaatccg tttccccact gcaaccggca catttggcaa 2456281 ataaatcgcc agctcctctc ctccccagcg ggcaccgaca tcatgctttc ggatgttgct 2456341 tttaatcact gaagcgactt gaattaaaat ctcgtcccca gtctgatggc cgtacgtatc 2456401 atttacattt ttaaaattat caatatcaac aagaataaaa acaccctttt gatggatttt 2456461 catgctgtat tgaatttttt catctaaata cgctcgtgaa tacagttcag tcagctgatc 2456521 tgttttcacg agatgctcaa ggcggtcgcg aagcattgaa ttggttacag ccagtgtcgc 2456581 gtgatgaatc agcgcctgaa acagcttgta catttcaaat gtaaaagcgt acagctcctg 2456641 tttcaataaa accgcaaagc ctaaaagccg gtcgttttga atcatcggag cagccatcag 2456701 cgagccgtac cccgccttcc caaaaacaga ctggccattc ccgatgaaaa cccctttttc 2456761 accttcatac agcttttctt tcagctcatt ataaaaatct gacggcttcg cttctttaaa 2456821 aaatgctgtg ctgcctggga gcaatgttag gttttcaaaa tggtctatat gaaaaaatcc 2456881 cacttcttct gcctgaaacg attctgccat tctcacagcc agatcattca ttgtatcagt 2456941 caatgtcagc cgctgattca ggcgtcgtga tgtttcatta atcaattcca aatttgcgat 2457001 gcttgctttg gattgttcgt agagctgggc attttcaaac gcttttcccg cggcgtttgc 2457061 taacagcgac atttcatcaa ggcaggcatc agtaagaaag ctgtcacccg ttccttcagc 2457121 cttcaacacc ccgtatgtgc cctgctgtcc tttgatcgga atataggcga cagattcatt 2457181 tttccgcaaa atgtctccgg acaaatacac tttgagcgca aaggaatcgg atttttcccc 2457241 ttccatatac agctcttttg caggaatccc taaacattgg tcttgatcgt gcgatataaa 2457301 taaagaaaac tcaaaaagag aaaatgtgct tgtcaagctt tctaaaagct gcttcagcac 2457361 atctgtctga tcaagcagtg aatggaacag ctctgtcatt ttgtatatct ttttttggta 2457421 gatcgttttg ttatagagtc tttcctgttt catcgactgg tttaaaaatg aagcaaccac 2457481 gtccggaagc ccttcaggaa tctcttcatc ctgcctgcac gcaagatgga aacgcctgcc 2457541 ggagccgtcc tcaatcagat aacatgaagc gtttattttt gaagcggaaa aacgcgcttc 2457601 accatctgcc agttttgtca caaagtctga tggtgacggt gtaagcgaaa cacaaagggt 2457661 tgaaaaatag gtttgaatag ccgaagtcag ccatatgaaa gagtcggtga atgtgacttt 2457721 ttcagatttg gttaataaaa aatcgagcat atgataatga aaggcggata attgatcttt 2457781 agtttgttct accatgtttt tatcacctaa aagtttacca ctaatttttg tttattatat 2457841 cataaacggt gaagcaataa tggaggaatg gttgacttca aaacaaataa attatataat 2457901 gacctttgtg tgaaatattg cagccttttt gttcagcttc tatgttttca ttttgttcct 2457961 tatcaataag gtgtatcgtg taactctctg ctgctggagc gaggatacat gaaaacaaaa 2458021 tgtgcatggt cgaatagagc agacggtttt tattttccac aaaaataaaa ccaaaggagg 2458081 agtcacatta tggctcgcta tacaggtcca tcttggaaac tgtcccgccg tctaggaatc 2458141 tctcttagcg gtacaggaaa agaattagaa aaacgccctt acgctccagg tccacacggc 2458201 ccaggacaac gtaaaaaatt atcagaatac ggtttgcaat tgcaagaaaa gcaaaagctt 2458261 cgtcacatgt acggtgtaaa cgaacgtcaa ttccgcactt tgtttgacaa agctggcaaa 2458321 ctagctggta aacacggtga aaacttcatg attcttttag attctcgtct tgataacgtt 2458381 gtgtacaagc taggtttagc acgtactcgc cgtcaagctc gccaattggt taaccacggt 2458441 cacattcttg tagacggaag ccgcgttgac atcccgtctt acctagtgaa acctggtcaa 2458501 acaatcggtg ttcgcgaaaa atcaagaaac ctttctatca tcaaagaatc tgttgaagtg 2458561 aacaacttcg ttcctgaata ccttactttc gacgctgaaa agcttgaagg tactttcact 2458621 cgtcttcctg agcgttctga acttgctccg gaaattaacg aagcgcttat cgttgagttc 2458681 tactctcgtt aatcgtttta aaaacccctg ccgctatgcg gtcggggttt ttttatcggc 2458741 tttcgcctct tgctggccaa cactatcttg cgcctgctgc tcccaatgat cccgctgcag 2458801 ccgttctttt gcaatcgtac acatgagatt cacgctttag cgctcctttc atttaaaagg 2458861 tggtgattgg tcgtgtttgc cctatctaat atactctttt cctttcattc ctatgcggta 2458921 aacaaaaaga tcctttgcct tcagtggcaa aggatctttt tcttatttat acgtcacaag 2458981 gaagtatttt ttcttcccgc ggcgcagaac agtaaattgg ttttcgatgc ggtcttcacc 2459041 tgatagggta taatttattt ccgtctggcg ttcaccgtta atgtaaacag ctccgttttg 2459101 gatgtcttca cgcgcttggc gtttagaagg agataattta gattgcacca acacatctac 2459161 aagtgaaagc tcttgggtgc tgtcaacttc catagaagga acatctttaa agcctacttt 2459221 tacgtcttga gcagaaagct ctttaatatt gccgctgaac agcgcttggg agatgttgat 2459281 ggcttgctcc agcgcctcgc gtccgtgaac aagtgatgtc acttcttctg ccaggcgttt 2459341 ttgcgcttca cgtttttctg gcgccgtttc tgttttttca gcgtatgctt caatttcctc 2459401 ttttgaaagg aacgtgaagt atttcaagta tttgacaacg tcacggtcgt ctgtgttgat 2459461 ccagaattga tagaattcat atggcgatgt tttttcttta tcaagccaga tcgcgccgcc 2459521 ttccgttttt ccgaacttcg tgccgtctgc ttttgtgaca agcggaatcg ttaggccaaa 2459581 cgcttttgct ccttcttctt ctgattttct gatcagttca agacccgctg tgatgttgcc 2459641 ccactgatcg cttccgccga tttgcagttt acagtttttg tctctgtaaa gatttaagaa 2459701 atcataagat tgaagaatca tgtagctgaa ttccgtgtac gagatgccgg attcaattct 2459761 tgagctgacc gtatcttttg ccagcatgta attgatgccg aaatttttac caacgtcacg 2459821 aaggaaatcg atcacattca ttttgccgat ccagtcaaag ttgttcgcga tgacagctgg 2459881 gttttctgct gcttcaaaat ctagaaatct ggacagctgg tttttgattt tttgggacca 2459941 ttcggatacg atgtcagcag tgtttaatgt acgctctgct ttttttccgc ttggatcacc 2460001 gatgaggccc gtcgcgccgc ccacaagcgc aatcggatga tgccctgcaa gctgaaaacg 2460061 gcgaagtgtt aaaataggca gcaggtgtcc gatatgcaag ctgtctgctg tagggtcaaa 2460121 gcctgagtac aagcggattt tttcttcatt cagctgttta tttaaccctt cttcatctgt 2460181 catttgctga atcaatccgc ggaaggataa gtcttcaagt aagttagtca taagataaag 2460241 ctcctttttt aattaaaata aaaaacgccc cttcgtttac acgaagggac gattgattat 2460301 cgcggtacca ccctactaat aagagaatgc aaacattcgt cttatcactt tgcctgataa 2460361 cggatcaggt ccgttctttc actactgaaa gcctggccgg ctttgtttgc aaaagcggtt 2460421 catgagtgta ttcgatatat ccgtctgtgc tgattttcac cggccatcag ctctctggaa 2460481 cgtaaggata ttctacttgt ctcaatcttt accttttcat atgaagctat atcattttta 2460541 acataaataa aatcctgtgt caacgccgcc ttttaatcct ccattgttga cagatctcca 2460601 gccggcagat taagctccca tgccttcagc acgcgcctca tgatctttcc gcttctggtt 2460661 ttcggaagct tatctttaaa ttcgatctca cgcggagccg catgggctgc aagaccctgc 2460721 tttacaaata ggcggatctc ttctttcagt ttatcagacg gctcaaatcc ttccctgagt 2460781 gcaataaagg ctttaatgat ttctccacgc accgggtcag gctttccgat aacgcctgct 2460841 tctgcaatag ccggatgttc gacaagcttg ctttccactt caaatgggcc gacgcgctca 2460901 ccggaggtca tgatgacgtc atcaactctg ccttggaacc aaaagtatcc ctcttcatcc 2460961 atgtaagcag aatccccaga cacataccag ccgcccggca tgaaatacga ttcatacttt 2461021 tcagggttat tccaaatggt atgcatcatg gaaggccagc cctttttgat ggcgagattg 2461081 cccattcggt acggcggtag ctcgttgcct tgattgtcaa cgatcgctgc ctccactcct 2461141 ggaatcggct tacccattga acccggttta atatccatgc aaggatagtt gcagatgagc 2461201 tgactgcccg tttcggtcat ccaccaggta tcatggattc gtttgttaaa aactttatgt 2461261 ccccatctga tgacttccgg atttagcggc tcaccgacac tgagcacatg ccggagtgaa 2461321 gttagatcat atttcgcagc catttcatct cccgctccca tcagcatccg aaaagctgtc 2461381 ggcgcgctgt accagacatt gacgccaagc tgttcaatcg ttccatacca gctttccggg 2461441 ctgaaacgtc cgccgacgat gacatttgtc gctccgttca gccacggtgc aaaaatgccg 2461501 tataccgtac ctgtcaccca gcctggatca gccgtgcacc aataaatgtc ttcttccttt 2461561 aaatcaagga cccactttcc tgtttgatat tgctgaatca tcgcttcatg gacatgcaac 2461621 acgccctttg gcgtaccagt ggaacctgat gtatagtgaa gcagaaagcc gtctttttta 2461681 tccatccatt cgatatccaa tcttgtgctt tcctgtttcg ctgcttcatc ataattgatg 2461741 atattcgtgc cgctctcagc ctctcccccg actacgaaga catgctgcaa gtgaggcagt 2461801 ttgtctaccg gtattctctc cagcagctca ggcgttgtga caacaacctt tgcctcactg 2461861 ttttcaagcc ggtctttcac cgctccctcc ataaatgctt cgaacagcgg cccggcgatg 2461921 gcgccaattt tgattgcgcc aagcataata aaataaagct cgggtgatct cggcataaaa 2461981 ataaaaacgc ggtccccttt ttccacattt ccataccgtc tcagcacatt cccggctctg 2462041 tttgattctt ccttcatttc tttaaatgtg tatttttcat ccctttttgc gtctttataa 2462101 taaagcgcta ctttgttttt tcgaaacgat tcggcatggc ggtcaatcgc ttcatacgcc 2462161 gcattcagtt tccctgtctc atgccaagag aaatgtttct ctgcctcggc ccaatcaaaa 2462221 tgccggtacg tttcttcata gttttttaag ttatgatccc cctctattgc tggtaacgct 2462281 ttcaagttca tgcccaaaca tccccctttg ctgaagttgt cacaattatt atagtatata 2462341 ttcatattct tctcaatttt taaaatataa accatgttga aaacgcttta taatttggta 2462401 ttcttaaaga aggcatgtat ttttgataag aattgatggg acggtgaatt agtggaacat 2462461 cataaaacat accattcagc aaacatcaaa acagcaaccg gctctttact gatagaaggg 2462521 cctgtctctc cagaggattt ggcaggttat gagtttcata aagatttaac cgcatttcgc 2462581 ccgcctcgcg agcagcatga agcgctagtc gacattgcag gccttcccga agggcgcatt 2462641 attattgcca gagacggccg aaccattgtc ggctatgtca cgtatttata tcctgacccg 2462701 ctcgaaagat ggtctgaagg aaatatggag gatttgattg agctcggagc catcgaagta 2462761 gcgccggact atcggggatg cgctgtcgga aagacgctcc tgaccgtcag catgatggat 2462821 gaacaaatgg aaaactacat tgtgatgacg acagaatatt actggcattg ggatttaaaa 2462881 gggatgaaaa aagatgtgtg ggaatacaga aagatcatgg aaaagatgat gaatgcaggc 2462941 ggattggtct ggtttgcaac ggatgagccg gagatcagct cccaccctgc aaactgtctg 2463001 atggcccgca ttggaaaaaa cgtcagccaa gaatcaattg agcaatttga caggctccgt 2463061 ttttatcatc gttatatgta ttaactgaca ctgacaaagg ggaaaaaata atgattgttg 2463121 agcaaatcat gaaaagagat gtcattacat taacgaagac ggatacgctt gaaacagcaa 2463181 tatgcaaact gaaggaattc catatcaggc atctgcctgt tgtagatgaa gaacgacacg 2463241 tgatcggcat gattacagac agggacatga aacaggccag cccgagtatt tttgaagaaa 2463301 acaaacgaag cctatttctc acacgaagcg tagattcaat tatgaaaaag gatgttgtct 2463361 gcgcccaccc gttagatttt gtcgaagaaa tatcagccgt gttctacgag catggcatcg 2463421 gctgcctacc agtggtacac catcaaaaat taataggcat tttaacaaaa accgatttgc 2463481 tgcggacgtt tgtcaaattg acaggcgctg accagccggg ctcgcaaatt gagataaaag 2463541 taaacgacat caccaaaagc ctcgctgaga tcagcagtct ttgccaagac cttcaagtga 2463601 aaatattaag cgtgcttgtt tatccgcatg acgatcccgg tgtaaaagtg cttgtcttcc 2463661 gtgtaaaaac gatgaatccg ctgccgtttt tgcaggcatt acaaagaaat ggacaccacg 2463721 tcgtatggcc gtcagagcaa agggatctgc tatgagagac agtgtattta tctattctcc 2463781 atcctaccaa acctatatgt ttcatcagga gcatcccttt aatcagcagc gggttctgtt 2463841 aacatatgat ttgcttaaga cgatcaatgc ctttgatgat ggagacattg tcacccccag 2463901 actcgcttca gaagaggagc tttcccttgt ccacacggac gattacattc aggccgtaaa 2463961 gcttgcgggc gccggaaagc tccccgctga agaaggagaa agctacgggc tcggcactga 2464021 agacacaccc gtctttgccg gcatgcacga agcggcatca ctcttggtcg gcggcacttt 2464081 aacggccgca gactgggtca tgtcaggaca agccctgcat gcggcaaacc ttggcggagg 2464141 gcttcatcac ggctttcgcg ggagagcatc aggattctgc atatacaacg acagcgctgt 2464201 ggctattcaa tatatccaga aaaaatatag cgccagagtg ctttatattg atacggacgc 2464261 ccaccacggg gacggtgtgc aatttacatt ttacgataat cctgacgtat gcacgctgtc 2464321 cattcatgaa acaggaaggt atttattccc tggaaccggt cagatccaag aaaaaggaag 2464381 cggaaaagga tatggctatt cctttaatat tccgcttgac gcttttacag aggatgattc 2464441 ttttcttgag gcttaccgga cagcagcttc agaagtcgcc gcgtatttcg agcccgatgt 2464501 cattatcagc caaaacggcg ccgatgccca ttactacgac ccgctgacgc atttatcagc 2464561 aacaatcaat atatacgaag aaatcccccg tcttgcacac actttggctc atcaatattg 2464621 cggagggaaa tggattgcag tcggaggcgg cggatatgat atttggcgtg tcgtgccccg 2464681 cgcctgggcc agaatatggc ttgaaatgaa gggaattgac ccgggtcacg agatcccgcc 2464741 ggaatggatt gttaaatggc aaaaacaatg ccccgtggcc cttccgtcga gctggagcga 2464801 tccggctgat ttatatcctc cgattccccg caagcctgaa attacagaaa aaaatgccca 2464861 aactgtcagc aaagcattat atgcgatacg ttctgaacag caaagaacaa agtaaaaaac 2464921 gacctttacg aagaggtcgt ttttgatttt ttaatcacta tttccacacg ccgattttcc 2464981 ttcatgtgtt catttgtctt gttatccttt actggctttg tatccgcata accgacagca 2465041 ataaagcgct tggagggaag cttctcttta gacgtgaagt attgaatcac tccacttgcc 2465101 cgtgctgctg atagctccca gttcgacggg tatcggtatg tcgaaatgtt tcggctgtct 2465161 gtatgtccct caacctgaat gtcatttgga attgtttgaa gaagaacggc aatttggtga 2465221 agaagtgttt cggcattttt cagcaccttt gcctcacctg tatcaaacag cacagcctcc 2465281 tgaagaacga gcacgacacc gcgttcatcc cgtttggctg tcatttgggc cttcaaatga 2465341 ttgtctttta tatatgtatt tactttcttg agaagctgat cctgctgatc ctcttgcttc 2465401 ttcgtatcag atggggatgt attctttttt tctatggatg tttggtccgg ctgaagcccg 2465461 ttgccttcct tctggatcga gtccactgcc gctttgaatt tttgcagatc gatttgggac 2465521 atcgaaaaga gtaaaataaa gaacacaagg atcaaggtga tcagatctgt aaaggttacc 2465581 atccagctgg atgaagattg actgtttttt ccgcttccat tccttctttc aaaacgttct 2465641 cttctaagct tcatgtacag atcccttttt tgtttttact tgttttggct gcttctgcca 2465701 ttcttcccgt gagctgaaaa cgaccagctg gctttcaagg ttgcgcgggt tttttccgga 2465761 ttgaacaccg ataatccctt ccaccattac ctgcttgatg aaaatttcac tttctgtttt 2465821 ctcttcaagc ttagccgcga tcgggttgaa gaccatattt gccagtaatg aaccatataa 2465881 agtcgtcaga agcgcaatgg ccatgtttgg tccgagcata tgcgggtcgt ttaagttttt 2465941 gagcatcagc acaagcccga cgagtgttcc gatcattccc catgccggag cgaattctcc 2466001 cgctttttca aaaactcgcc gcccttttcg gtgccgttcc tccattgctg cgatttctga 2466061 atccatgacg agccgaatcg tttcttcatc ccagccgtca atcgctaaaa gcagcccttt 2466121 tttcaagaat ggatctttga tttcccgagc ctgatcatcc aatgataaaa gcccgtgttt 2466181 tcgcgcgtga tcggaaaggg aaacaaaggt tttcacaaga tctttcacat tgtcttcctg 2466241 gcggatgaat gcctgcttta acacagaggg cgcttttttc agctcacttg gcggaaaact 2466301 gataaaaaca gcggcgcaaa gtccccctgt tacgatgaag aaagaggtca gatcaagaaa 2466361 agagcggaaa ccgcttactc ccgatcctga aataatcccg ataacaataa taatcgttcc 2466421 taacacaaat ccaacaggtg taagataatc aaaacgtttc atcatttctc cccatgaaaa 2466481 aagcaagaat tcaccataaa ggtgaagctt gctctttgtt tttcttatga cttggttgac 2466541 tttctaagct ctatacggtg cggcagttcg acgatatgct cttcaaccgg ctctttattc 2466601 atgagcttcg tcagcagtct catcgcaacg gcgccgatat catatgtcgg ctgaacaact 2466661 gttgaaagct gaggacgaac catgaggctt aatcttgtat tatcaaaacc gataatgtcg 2466721 agatcctccg gaatggataa gccctgatcc tgagcggcat ggataatgcc gagtgccatt 2466781 tcatcagttg cagaaagaat ggctgtcggt tttttatcca ggctcatcag atgctgcagt 2466841 gcttcgagtc cggaatcata tgtgtaatcc ccttcagcta caaattgttc attaaacgga 2466901 aggttcgctt cttcaagcgc acgtttgtag ccttggagtt ttttcgaacg gttgatcggt 2466961 tctgccattg gtccggaaac gaacgcgatg tctgtatgtc ctttatcaac caaaagcttc 2467021 acggcatcat aaatcgcctg ttcgtaatcg atagcgactg acggtgtttc ctcctgctct 2467081 tctacagaag cggcaagtac aatcggcact ggagaacgct taaattccgc cacatgctcg 2467141 tccgtaatgt ttccgcccat aaacacgatg ccgtccactt gtttgccgag cattgtgttt 2467201 aacaagtgca gctctttctc catgttttgg tcagagttgc tcaaaataat attgtattta 2467261 tacattgtcg cgatatcttc aattccgcgc gcaagctctg aatagaaaat gcttgagata 2467321 tcgggaatga tgacacctac agttgttgtt tttttacttg ccagccctct tgccaccgcg 2467381 tttggacggt aaccgagacg ttcaatggct tccaagactt ttttcctcgt tgtcggtttt 2467441 acattcgggt tgccgttcac gacacgggaa acggttgcca tgcttacatt agcttctctc 2467501 gctacatcgt agatcgtaat attgctcatc ctaaaaccac tccttttact ggatacactt 2467561 atccttatct atagcataaa cactttatgt agagaaatgt cataatgtcc gaatttatgt 2467621 cgtttatgat ttgtaagcgt aagtcagtag tgtacattat ttttcattat tcatcaaatt 2467681 taattacttc tcatgaaatt atacacgttt ttatagatga tgaaaacgta tacttggttt 2467741 ttataactaa ataaacgaga aagcataaaa aaaggccgca ggcgcggcct tttggattgt 2467801 tcaattaagc gttgactttc accattggct tcagttcatt cagccatttt tcgaattcag 2467861 gaatcgccat ttgctgagca gagtcagaaa gtgcgactga cggatcaggg tgaacctcag 2467921 ccattacgcc atcagcaccg atcgctaaag cggctttagc tgtcggaagc aagaggtcac 2467981 ggcggcctgt tgaatgcgta acatcaacaa agactggcaa atgcgtttct tgtttcaaaa 2468041 tcggcacagc tgaaatatcc agcgtgtttc tcgttgctgt ttcatatgtt ctgattccgc 2468101 gctcacaaag gataatttgg tcatttcctt gtgacatgat gtattcagca gcattgatga 2468161 attcagagat cgttgcagca agaccgcgct tcagaagcac tggctttttc acggcgccgg 2468221 ccgctttcag caattcgaag ttttgcatgt tgcgcgctcc gatttgaatg acatcaatgt 2468281 agtccagcgc ttcttcgata tgagccggag ttacgatttc actgataacc gccagatcaa 2468341 attcatccgc tacacgtttt aaaatttgaa ggccttcaac accaagccct tggaaatcgt 2468401 atgggctcgt acgaggctta aaggctccac cgcgcaaaat tttaatccct tgttttttcg 2468461 cagctgcagc gacttcagct acctgctcat agctctctac cgcacatggg ccgacaatga 2468521 atctttgctg gccgtctccg attttttcgc ctttgatatc aacaattgta tcttcaggtt 2468581 ttttcttgcg ggagacaagc agcgctttgc tgtgatcttc ttcctgaagc tctaaaccgg 2468641 ctttgaatat ctctttaaaa atgtgctgga tggttgaatt ttcgaacggc ccgtcattgt 2468701 tttcaatgat attgtttaac attgtgcgtt ctctgacagg gtcaaatcgg ttgacaccct 2468761 gtgcttcctt cgctttaccg atctctttta caacattgcc gcgttcgttg attaatttta 2468821 aaatttgtag gtttaattcg tctgctttct gccttaaaag ctctaactct gtgttgctca 2468881 tttttttcat cctttccctg cacattcatt ttttattttg tagttatcat gcatcttact 2468941 ataagtaatt ccaaatggaa atactgaaat acaaaaaatt ttataaaaac tctactttat 2469001 tacccaaacg cttttaagtg ataaagtaat ctatgaagct atcctacatg atgtgagggc 2469061 aatgttcaag ggttttttac aaaaaaaagc gccagatgat atctggacgc ttttttctat 2469121 gacaaatgct gctcaatagc ggcttctgta atttgtgaat gtgaggtatg ccatttcact 2469181 tcaccgttct ggatgatgaa tatctgaggg ctttcatgct tgaccccata tgtttctgca 2469241 atgaaattgg acagcggccg ggcttcttgt acttgaagat agtaagccgg cacatcctca 2469301 tgctgatttg caaaggcatc aaactcatga aatgctgcct ggctgatcgg gcatgtggtg 2469361 ctgtgtttca agaagacgaa aacgccttcc tgttctgcaa tccgtttaaa ttcttcctca 2469421 gattgaataa gctgtttagc catgactcaa gctcttcctt ccctgctcag cgattcaact 2469481 gctcagcctg tttttgtgca tctttcagtt cgtcttttac atcttctttc gtctggagga 2469541 cttgatcttt tgtttcatca gctgcctgca tcgcttcttc cctcatatct tgcattgcag 2469601 tcgatgaatc cgttttgtca gatttggaac ggtctctcaa atcctttacc ttgttcatga 2469661 tctgtccaga ctgatccgct acaagctgtg tgatgttgga agttttgtct tttgcgatgc 2469721 tgacatattg cgtgcctttt tccttcgcat ctgccgtcat tttatcagtt ttgtcccgta 2469781 aggcaacagc ctggctgccg agatcgtcgc gaagttcttt gcctgattta ggcgctagaa 2469841 aaagagctgt agtggcaccg atgattcccc cgattaaagt tccgattaaa aaatctttac 2469901 tattaattcc atctttgctc atcattattc ctcctcttag tatttttttc tcttacaggg 2469961 ctgatttttt cttttgcttc catttctccc aaatttccat tgctgcttga ctccaagtga 2470021 caacttgatt gatcttatct tgattctctc taactgatgc cgatacagac cctgccgctt 2470081 gtttcatgga tgtattgaac tgctgtacag aagctcccac tccttgaaca gcatgaacga 2470141 ccgtgttcag cttttctgat ttttcctgaa tatcttcagc caggcggttg gtcttatgta 2470201 aaagctcggc tgtttcagtt gtgatgccct tcatttgtcc ctccagccct tcaagagtgg 2470261 atgcgacgtt ttttagtgtc agctgcagtg acttcaatgt tttagacaag tagatcacta 2470321 atacgagaaa tgcaactgcg atgagtgcaa cgctcaaata aagaataata atcatctcaa 2470381 acctccttgc tgcaggatat actgctgttt acccgttttc ttcaatcata aacatgtgta 2470441 ctgggctgta tacatactat tctccgttat gtaagaaaat cctttaataa gctttcccat 2470501 cagataaata aaaagcagtg agatcactgc tttttattat gccatgacgt tttcgtaggc 2470561 tctcatatat ttttggatat ctcctgctcc catgaagatg agaacggctt tatcatgagc 2470621 ttttaaaaca gatgtgtcat cttcttcaat cagcttggca ttatgaattt ttccctggag 2470681 atcaccgatc gtcagctttc cggcattctc acgggctgag ccgaaaatat cgcataaata 2470741 cacacagtcg gcgccgctca ggctttctgc aaattcgtca aggaactgct gcgtccgggt 2470801 aaatgtatga ggctggaata ccgcgacaat ttcccgatca ggatacttct gtcttgccgc 2470861 ctcgattgtc acttttattt ctgtcggatg atgggcatag tcatcaatca gcacttgatc 2470921 cccaagctgc ttctcattga atctgcgttt gacgccccca aaggatttga gagcatgctt 2470981 aatgatgctg gaatcaattt cttcataatg gcataacgca atgaccgcca atgagtttaa 2471041 tacattgtgg tggccgtacg caggaatata aaacgtatca tagaacgtat tgcggacaaa 2471101 gacatcaaaa gttgtccctt ccgtgctttt tacgatgttt ctggcttgaa aatcattttc 2471161 ttcccccgtg ccataataca caaccgggac gttcgcatgg attttcggca gatgctcatc 2471221 gtctccgcag gcaataatgc ctttgttgac ttgaagagcc atctcttgga aagcgtcaaa 2471281 tacatcgtca atgcttgaga agtaatcagg gtgatcaaaa tcaatattcg tcataatcgc 2471341 ataatctggc tgatagctta agaaatggcg gcggtattcg cacgcttcaa acacaaagta 2471401 ttcgctgttt tcatttccct ggcctgttcc gtctccgatt aagaaagacg tcggttttgc 2471461 gttttggatc acgtgagcca gcagacccgt agtcgacgtt ttgccgtgtg cgcccgtaac 2471521 ggcaacactc gtgaattttt tcatgtagtc gcctaaaaac ttatgataac gtatcaccgg 2471581 aattccctca gacatcgctt tttctatttc aggatgcgtg tctgggaatg cgtttccggc 2471641 gatgactgtc atgccgggtt taatattttc cgcgctaaaa ggaagaatcg taatatttct 2471701 tttttcaagc gctgtttgcg taaaaataaa tttttcgata tccgatcctt ggacagtata 2471761 tccattatca tgaagtattt gggcaagcgg actcataccg gtccctttta ttccaacaaa 2471821 atgataaaca gtcataattg tacctccaac aaacgtctat ctgttcccca gtatatgacg 2471881 ctcatttcaa tttgcgaccg cggcggctga aaagcctccc ttagcggcgt attttatatg 2471941 ttttgttatg tttagtatca ggttatttct ttccgattaa acccagatat caagatttgt 2472001 ctatgcacag ctgctgtaaa gcggcatagc tgttaaatgc tctaaacact atcataccat 2472061 gtttggtgtg aaaatgaacc catattattc gtttattaaa tcacttgctg tgatcagcac 2472121 ctctcgaggc ttgcttcctt ttgcctcaga gatcatgcct tccgcttcca tcatgtcgat 2472181 cagccttgcc gcacgattgt aaccgattct gaatcttctt tgcaggcttg aagtgctcgc 2472241 actgttttgc tctacaacaa actcacacgc ttcgtaaaac agttcgtcct cttctttcag 2472301 ggcagatcct tgtcttacga gctcttcttg ttcaaataaa taggtcggcg gcatttggct 2472361 tctgacgtgg gaaacgacgc ggtcgatttc ccggtctgac acaaagttac cttgcagacg 2472421 aaccggtttt cccgagccgt tttccaaaaa gagcatatcc ccttttccga gaagcttttc 2472481 tgcaccggct atatcaataa ttgttcggga atcaacctgg cttgagacag aaaaggcgat 2472541 tctcgttggg atattcgcct taatcagacc tgtaatgaca tcgactgacg gacgctgagt 2472601 tgcgacgaga agatggatac cgcacgctct ggctttttgg gcgatccgcg caatgctttc 2472661 ttccacatcg tttggagcca ccatcatcaa atctgcaagc tcatcaataa tgacaactaa 2472721 atacggcagc ttttcaccca tttggtgttc agcggttaat tgattaaagc ggtcaatgtc 2472781 gcggacacct gaatgggcaa aaagctcata gcggcgctcc atttcctcaa cgacccattt 2472841 caaagcagcc gtagccgctt tagcatcagt aatgaccggg ctgacgaggt gaggaatttt 2472901 attgtaaggg gccagctcta ccattttcgg atcaatcagc agcaccttta cctcactcgg 2472961 gtcagcttta taaagcaggc ttactaatat tgtattgatg catacgcttt ttccggagcc 2473021 tgtagcgccg gcaatcaagc catgcggcat tttcttcaag tcgataacaa caggatttcc 2473081 cgaaatatct aatcccagcg cagctgtgag cggtgacttg cttgtcctga aagctgagct 2473141 gcgaatcatt tggcgcaaat caaccacctt gctcgtgcgg ttcggcactt caattccgat 2473201 cgtgtttttc cccggaatcg gcgcttcaat ccgaatatct ttagctgaga gactgagttt 2473261 aatatcatcg gacaagttgg tgattttatt cacctttaca cccggttcag gatgcacttc 2473321 aaatctcgtg acagacggac cctgggttac atggaccaca ttggcgcgga cattgaaatt 2473381 tttcaaggtc aaatcaagaa gctgacgctg ttcttcgatc cacgcagtat catcttgaac 2473441 ctgcgctggc gggacatcaa gcagtgcaac attcggaaat acatagctgc cgcggcgctc 2473501 ctctgctttt tgctgtttat gcgtatctct tttcagcatc atcacattaa aaggaacgga 2473561 tggccctttt tgagaagatg cgctttgttc agtccttttc tcctgtacac caggcctttt 2473621 tttcggctct tctgaagctt cgcgaggttt gtctgcgcga atttcctgcc ggttttcaag 2473681 agttgcagta gacgatttgg aaccctgctc catgtgttca gttttctcaa gctctgtatg 2473741 gctgtctggc tgaacatcta tcttcgtttc ctgagcctct cccagggtgt cataatgatt 2473801 atttattatg ctttctgatg gctcttctga ttcttttgcc acagtttctg cttgagccag 2473861 agcctctgat gaatactcat gatcagtaaa taaaggctct tcctgacgaa tgtccatttg 2473921 ttcttcttga acgaacgggg actcagcacc ttctgccgcg ttttcatgat gattgtatac 2473981 tgggctgtct gacggctctt ttgctttttc atcctcagat actgcctctg tctgagattc 2474041 aggagctgtt tgctcttcat caagttcagc ggagaaaaca ggctcttcaa atttctctgg 2474101 ctgctgctcc ctttgttctt cctcagccgt tgcaggctct tcgcggccta cttcactgtc 2474161 tgaaagccct tcagccgccg tatctgtgag catctcaggc ggtgtttgct cttcggcttg 2474221 ttcagctggg aagaaaggct cctctttttc cggctgttga acgcctgact caaatggcac 2474281 tttgttacct gacggctcgg ctggccgttt cgccagcgcc tcatcatgct ccgtatcctt 2474341 tctgtttaaa acgccagaag gctgtttttc aaattgggta tccgggaaga aaggactttc 2474401 tattttggaa tgcgcctgtg tgtctgaagc aggatagccg cgttcacgtt cgatctcttc 2474461 tgacagcagt gttaccttct cttttaccga tttatccggt tcgttcaatg tttcagaagg 2474521 ctttttcggc acatcctttt taacagatgg tttttgattg aatccataga caggcgaagg 2474581 gatatttgtc ggtttaaacg gtttcttcgc cggctctgct gcttgatatg tatgctgctc 2474641 ttcttcattt ctgggacgct ctctgtaagg tgcagcactt ggacgaggcg cggatttcgg 2474701 ttcgtccgat ggtgtgcggc gccttctcag gtcatgattt ttgtatccgt caggcacgac 2474761 tggaaaacgg aatttgcctt ttggatattc ataatatatt ttaggatctt ccaatctttt 2474821 taattgtcct tcaggatgat gtacttcttg ttgctgcgga atttgagcgg gttttgtctc 2474881 ccgttcagca tcctcttcgc tttcgcctaa aaacaaatca aaaaatttat gaagccaact 2474941 cataatttat ctctaactcc cttatagttt tctgggacgg tttttagtat accactgctg 2475001 gtcggcccag aaaagattaa gctatcagca gaaacaaagc cgctaaacaa gggcttagcg 2475061 gcttttcaca tgattcgttt tttttggcgg atttatggga gtctaaaact gaaatgcgtc 2475121 tcccgcctca tagtctcctt ctaacacaag gattcctttt tcagcagggg catccggcaa 2475181 atcaagctct ttcgctgagc agatcatccc gcttgacgga acgccacgaa gctctgcatc 2475241 cttaatgaca agtccgctag gcatcacagc accgactttg gcaacgacaa ctttttggcc 2475301 ttggtcaacg ttaggcgcgc cgcagacgat ctgaagcgtt tcttctccta cgttgacttt 2475361 acatacgctt aatttatccg cattcggatg tttttctttt gattctacat aacccacaac 2475421 aaacttcgga gataaatcaa cgactaatgt ttcttcaacg ccgtttctgt ttaaaatctc 2475481 attcacatct tgcacgaatg tttctgagag cgcaacaggg ccgttttcat caatggtcaa 2475541 gtaagaagac gcattgaaaa tgttgaagcc cgttgtttct tttgtttcgt tattgaaaat 2475601 tttgacgacg tcgccgtgtt tttcatagcc taattgttcg cgtgtcacat cttgaagaga 2475661 gatcaggagc gtgtctccca caccttcttt attataaaaa gcgttcataa gtaaaaatcc 2475721 tttctaatcc tttttcggac ggcttttcgc caggataaac accggttcca gctttccttc 2475781 attgtacaaa aatgataggg cggtaatcgg gacggtgccg cctgcaaaga agctcatcga 2475841 catttgtcct agaatatcat accccgattc attccggatg tcagcaagaa tcaaaacgtc 2475901 ctgatgagga acagagatcg ccagctcacc ttctgcatgc tgcttatact catttaagat 2475961 cgcttcgttc aaaatccggc ttgcgtcgta tccgtcgttt gccctgaaga aataaaagta 2476021 attgccggca accgtatcct ctttgacaac cgtcggcagg gaacggagat taaatgcggc 2476081 cgtctctctg atccgctctt ttgtccagtt ttctttctca agcatgcgct ggtcaattaa 2476141 acggtaggtt ttcccgagat ctagcgcgta ataaattctt gtctctgcgg tatgatcgtc 2476201 ataaatgagc gggatatctt cgctggactt gtccgggaag gaagtcgagc ggatgaccgg 2476261 ataaatgcga gtttctttcc cggtcatttc ctgagccttc ccttccattg ccgtcatcgc 2476321 ttcggagaca tagtacacga tctcatcaat ggcttcgtct tttttcagtt cccattttgc 2476381 aataatcggc ggcaaatcga gtgtaatccc ttttttagtc gtttgatcct caacacggag 2476441 ggtgtctttt tctctgtcaa acagaaagga gcgattctcg tgctgaaggc gctgcttcag 2476501 tatatctgac agcttccttg aggtcatttt caaaccgatg tcctccttta cgctttagcg 2476561 agagagtctg ttaaaaactg ttcaatttct tcttttgttt tgcggtcttt gctcacaaaa 2476621 cgatttactt cttttccttc attaaacacc acaaagcttg ggattccgta aatttcccac 2476681 tctgcacatg tatcaatgaa tttgtcacgg tctacgtagt agtaggtgaa ttcagggaaa 2476741 ttcgcttcca gttcaggcag gaaaggctct acaaaacggc aatccgggca ccaatcggcc 2476801 gaaaacataa atacagacca atcatccttt accgcttttt ccagctcttg agttgattca 2476861 atttttttca tttcatatcc ctccagttgt ttatgttctt acatgttttt tatcgatact 2476921 cgtccatttg gatcatacca aactgcttga ggcaaaacca cttatatgca acgaatgaat 2476981 atgtaagatt ggctttccca ttatcattat catattttat ttgcattatc aagctcgttt 2477041 cgtttaacat cgtgtacatg agggtgaaat ttacagatgg atatacataa ggagggattt 2477101 ttattatgga gtttatcgtc tatttagcag gagaaatcca cagcaattgg cgcgaggaaa 2477161 ttaaagaaaa aacaaaatca ctgaagctcc cgattacgtt tgttggcccg atggagaatc 2477221 atgaccgctc agacaatatt ggtgaagaaa ttatgggcgt acagccaaat gccgttttaa 2477281 aggatgacaa agcctctgac atcaacaact tcagaaccgc cgtcctgatg aataaagcag 2477341 actttgtgat cgccctgttt ggcgaaaagt acaaacagtg gaacacggca atggatgcat 2477401 catatgcgat cgcaaaagga aaacccctga ttatcatccg gccggaatcg ctccaccatc 2477461 ctttaaaaga gctttccaat aaagcgaata ttacggttga aaccgttaac caagccatta 2477521 aggccctttc ctatctattt gaaacagaat aagaaaaaag cttgtcgatc cgggcttact 2477581 gctcgttcaa caagctttta tgaaacctac atattttctt taatcgcatc cactgtctgc 2477641 ttatcgcagg ctgttacaag tttgatgagc atttctttag cagcagcata atcatcaata 2477701 tgaatgatag tagcgtttgt atgaatatag cgggaacata ttccgataac cgctgacggc 2477761 acaccgctgt tcgaaatatg aaccttgcct gcgtctgttc ccccgccgga tacaaaatat 2477821 tgatatggaa tatcatgcgt ttcagccata tcaagaacga attccctcat tccgcgatgc 2477881 atgactgtcg ttctgtcaag aatgcgcagc aaaaagcctt ttccaagctg gccgaattca 2477941 tttttgtctc cgctcatatc gtttgccggg ctggcgtcaa gggcgaaaaa caagtccggt 2478001 ttaatcatat gagaagccgt ctgcgcgccc cttagcccta cttcttcctg aaccgttgca 2478061 cccgcataga gtgtattcgg aagctcttta ccgtgtaatt ccttcagaag ttcaatgctt 2478121 aagccgcatc catatctgtt atcccatgct tttgataaaa ttttcttttc attcgccatc 2478181 gtcgtaaacg gacaaacagg cacgatctgc tgtcccggtc taatgccgat tttgatggcg 2478241 tcttccttat catccgctcc aatgtcgatc atcatgtttt tgatatccat cggtcggttt 2478301 cgctgcgcat ctgtcaataa atgcggcggt atgcttgaaa tcacacccgg aaccggcccg 2478361 ttatctgttt gaatttcaac ccgctgcgca agcaaaactt ggctccacca gcctccgagc 2478421 gtctggaatc tgagcagccc gttgtctgta atggatgtca ccatgaagcc gacttcgtcc 2478481 atgtgcccgg ctaccataat tctcggtgcg tcctctgcgc ctcgtctgac tccgaaaaca 2478541 cttcccagtc tgtcctgaac gatgtcatct gcatatttgg ctagctcctg cttcataaaa 2478601 gcacgaacct gatgctcatt gcccggcgcg ccgggaagct gcgtcagtgt ttggaaaagc 2478661 gctttcgttt cttgattcat gttttcccct catttctatg tagtcctttt attttattag 2478721 aaacaatgaa gttttccaag cactctgacc caatctgctc gatcagccgc gtattgctta 2478781 acaggatttg gctgtttctg tataatgaaa agtacgatca accaggaggt gctttatttt 2478841 gaaattgcgt catcttcttt taggagcagg acttggaatt tgtacggctg tcgttgtgag 2478901 acaatatgtg atgaagcctt atatttcttc agaaaaagcg cttcgaattg taaaatctgc 2478961 ttttaagcag cggggcccga ttgacggatc atggatttac acccagccgg agccctacaa 2479021 tattaacgga gaaacggtac aggtatacaa aaccggcatt acacgatcag ctttcggaga 2479081 attagaacag tatgaagtca tggtggatgc gaaaacggga gaaattgttg atgtcattga 2479141 tacaatcgcc tcttaacacc ggacaagcaa aaaatagaag ccgctgccta tgcagcggct 2479201 cttttttatt atatcgcgcg aatcggtttg tataccggat accacatcgc atcctgcact 2479261 gcctgtataa tgtcttcagg ctcttccgta gcgacgcctt ccttcattgc ggtttttgca 2479321 acttcaacag caacggttgc cgaaacagtg cgcaaatctt caacttttgg aagcatcggc 2479381 gccccaggca ccccgacatt gaccatacct gcgattgccc gggcacatgc ttcaaacatg 2479441 ccgtcggtaa ttaattttga ttttgtaaca atcgttccaa gaccgagacc agggaagaca 2479501 agcgcgttgt ttgcctgccc gatatgatac gtaactccgt tatattcaac tggcgggaac 2479561 gggcttcctg tcgtgatcag cgcacggcct tctgtccatt cgattaaatc ctccggcttt 2479621 gcttcagaaa gagttgtcgg atttgacatt ggcaaaatcg ccggccgttt cacatgtgac 2479681 gccatttctt ttacaatttc ttcagtgaaa gcgccggaaa ccgtagatgt gccgatcagg 2479741 atcgtcggtt tcgcctgccg aaccacttca agaagatcaa tgcctccgcc gtctccgttc 2479801 cgctgataat ccttcacttc atcagccgaa cgggcatacg gcttttggaa atcaagaagc 2479861 tgatccatat catctgttaa cagcccgttc ctgtctatgc accagaagcg cttgtatgat 2479921 tcttcttcac tcagtccctc gcgcaccaat gcttcccgca gctgttcggc aattccgatt 2479981 cctgccgttc ccgctccgaa tataacaact ctgtgatctc tcagcggaac tttagacgct 2480041 tttgcacagg ataagactgc ggccaaagaa acagcgccag ttccttggat atcatcattg 2480101 aaggtacaca ctttatcttt atagcgtttc aaaatgcttc gcgcgttttt cgccccgaaa 2480161 tcctcccaat gcagcaatgc attcggaaat gtttctctcg ccagcgcaac gtagtcgtca 2480221 ataaattggt cataacgttc cccgcgcact ctggaatgct ggttgccgac ataaagcggg 2480281 tcgttcaaga ggctctcctg atttgtcccc gcatctaaaa caacagccag cactctgctc 2480341 ggatcaatgc ccgcagccgc tgtataaacc gccagcttgc caatagaaat tgcgattcct 2480401 ccgacgcccc agtcaccgat tcctaaaatt ccttccgcat cagttgcaac aattaaatcg 2480461 atcgtatcgc tttgatcttt atactgttta aaagcttctt tcataccgtc cgggtcatcg 2480521 attgacagat agagccctcg tggttttctg tattcatggc tgtatctctg aattgccgtt 2480581 ccgactgtcg gtgtgtagac aatcgggagc atttccccta aatggtcatt taacaggcgg 2480641 taaaacagcg tttcattccg atcgtgcagc gccgttaaat agacattttt gctcaaatcg 2480701 tcaggctgtg cggaatattg ttcatacgct cttttcgcct gatcatcaat tgttaatacc 2480761 ttgggcggca gaaagccttt taaaccaagt tcttttcttt cttcctcagt aaaagcaaca 2480821 cctttgttca aaaaaggaac agagagcact tcaaggcctc ttaatgttgt ttgaatgtct 2480881 ccttcgtttg ttactctgaa ttgtttcacc ctgcctcttc ctttctgagc ataatagtac 2480941 taggtttgca ttattagccg gaaaacatgc agggtaaaca taaaaatatg ctatcgcttc 2481001 attcgcttaa ctgacttttt gatgcttccg tcctcctccc attgaagggc gcgatactcg 2481061 gcatcatggt aaaaaataaa ccaagcatct ttttctgctg cgaacgcctg ccatttctgc 2481121 ttttgcggga tagaggtcat cggataatca tcgtaagcca gcacccatag cggattgcgg 2481181 tgggcatgtg tcggcatcag atctgccata tgtacggcag tttcacccgc atcctcgcat 2481241 atcaggacac tgtgtccgtc gctatggcct ccggtgtgat gcattgtaat accctctgtg 2481301 atcgttaagg tgtcttcaaa ggttttgact tggccagcta cagcctccca attttctttc 2481361 caatacgtat ttttcgacct gatattcgga tggcgcattt cgtcccattc aacagctgat 2481421 gtataaatca ctgcattcgg aaagacagag acgagccgtt caccttcata ttccgttaaa 2481481 ccgcatgcat gatcaaaatg aaggtgtgtc attgcgatca catctatatc ggcaaccgtt 2481541 aatccgagtg cagctaatga gggtttcaca ttcgactctt gtgtcacgcc atagtttcgt 2481601 ttttgtttat cagtcagctt gccgtaccca attccggcgt caatgatgat attgagccca 2481661 tccttttgaa tcaaaatagg gtctgttctt agttcaatct ggtttttttc attgactgga 2481721 tattttttag accaaagcgg ctttggcaca acgccgaaca tggcgcctcc gtccatatgc 2481781 gtcacgcctc cgtcaagcca ggtcaacgtg atgtttccaa ttttcattgt ttccattttc 2481841 acccccccct atcatcatgg tagcaaacgg cccataaaaa aaacagactc ctgtcagagt 2481901 ctgtctttac gttctccatt caacctcagc ccgatagatc ggctggccga gtgcagagaa 2481961 tttttcttca tattctgtca taatattgcc ttccagattg ctgttatgca aatcgagact 2482021 gacgtatgtc agcaggaggc cgtactcaga gaagctcttc aaagagtact caaataaacc 2482081 tcggttgtcc gttttaaaat gaatcgatcc gcctttgccc attacttctt catatttttt 2482141 gaggaagtgg gaatatgtca ggcggcgttt ttcatgccgt ttcttcggcc aaggatcaga 2482201 aaagttcaag tagacccgtt tcacttcccc cggctcaaac acatccgtca gcgtgtccgc 2482261 atctatattc agaagcttta cattctgcgc ttcgctgtct tttacttttt ggacggctgt 2482321 cacgatgacg cttttaaata actcaatacc aatataattg atgtcgggat tttgtttggc 2482381 cataccagaa ataaattggc cttttcctgt accaacctcg atatggatcg gattgtcgtt 2482441 gccaaacact gtgttccatt tccctttata atcagcagga ttgctgatgg caatatctgc 2482501 gttttcagcc aaaaagtcat cagcccaagg cttgtggcgc attctcatat gattgacacc 2482561 tctatctatt atttcgacta acaacatacc atgaattaaa aagacccgca agctcgtttt 2482621 tccagtgtat ctctcttaag gccgagcgca taaaaaaaga gggtcccgtc tgctggaaca 2482681 ctcctttccc atgtataaaa acgctctgtt ttgaacaatt taacccgtat gatactgaag 2482741 ggatgtgtac cgttatgggt ttacattatg agcatcaagt tcatttattg aaggatatat 2482801 tgactgacca tcaattggac tgctgcggaa cagtcgcaga gtacgagcag cttgagcgtg 2482861 tgattaaatc actgatggca aacaccgagc ttgattcaaa tttcaaaaac gtgcttgaag 2482921 atgtttaccg ctacagccaa tcaggaatat cgtccaaatc catcgactca cacatacaag 2482981 agcatcagaa cagcctgtct caatgggtag agcaaatgga ttcgtattcc tgattaatca 2483041 acaattcgtt tcatgaggat atgcagctct tccattgcat catgaaattc cttatcattg 2483101 ccttttgctt tatgccaggc aatgaaagta attgtttcag ataacacata ccaagccatt 2483161 cgcaaccgaa ggctttctgt cagctctatg ccgtacatgc tcagccagct ctcccaagct 2483221 ggcttttcga cgtagtggta cagcaaaggc ccgaggtcca tcgccggatc agcgatcatg 2483281 gcgccgtccc agtcaattaa atacagctgg ttgtcttcag acaatagcca gttattatga 2483341 ttgacatcac aatggcaaac gactttctca ccgaaatgca cttcatgcag gtgttcttcc 2483401 aaatacttga tcccttcttg aatcagcggc gaagattgct gcacagcaaa tacagcctgc 2483461 ttcagctgag acaaaagagc ccccgggttc agcggttctt ttccaagtct cttcagcatg 2483521 tccagcaagg cttttgatgt gtgtatttta cgaagcaatt cagcaacggg ccgtccgctc 2483581 atgtctttag gcttcagctc tctgccggtc atccagtgct gggccgtaat gacgtcccca 2483641 ttttccatcc gttttgtcca aaccagcttc ggaacaatgc cttcggcgga taaaacagct 2483701 aaaaaaggtg agctattacg ttttaaaaaa agctgctgcc cgttatgttt cgcataatat 2483761 gcatctcctg tagctcctcc ggcggggaag atctcccaat cgctacctag taattgtccc 2483821 aaccagttca tatcaatgtt caacccatca tttcttaaaa tattttagaa ttaaggctaa 2483881 tcgtttctag tctatccagc gaatgccttt ttcgtacgaa tcgtataaaa ataaaaaaga 2483941 cagctattga gagtctcata tgctaatcaa tagccgtcct ttaaatttta gcgctatagc 2484001 acaaacttcg tcaagcaaaa ctcttaagat ctgatgctaa atataagata accgttccga 2484061 tgccgtttac tgcaaccgtt ttcttgattt ctgttgggtc ttcctgaaat cctgatggat 2484121 cacataaaag ccgataaggt atgtcgtttg gcagcctcca ctcgacggag tctggactcg 2484181 cgtgatggat aacaatgata tctttccatt cgtcaacctc gtcaagatca taaagcctgt 2484241 atgcgataag gtgttctttt agcgtcaagc attcaagatg gcgctggatg tctgcagcgg 2484301 acctaagacg gaatgcagga tgcgcttttc tcagcgagat cagcctgcgg atatagtgaa 2484361 catcttcttt gaatgtttca cggcgatccc agtcgagctg gttgatgctg tcactggatt 2484421 gatagctgtt ttccactccc tgcttcgtcc ggaaaaattc ctggccgctg tgaataaacg 2484481 gcaccccttg ggcaagcaaa ataatcgcgg ctgcaagcct ttgcctgctt cgctttcggc 2484541 tgtcattttc ttgaggaagc gcaaagctca ttttatccca aaaggtgtga ttgtcgtgtg 2484601 attcgacata attgatggac tggcttggtt ccggaacaat cggtgctaat gccttccatc 2484661 cggaagaccc ggcaattcca tgcatcacag cttgtgctga ttcaccgttg ccgagcgcaa 2484721 accctgttgc cttaaggtga aaggtgttcc cttttacagc gtcacgaaac atatcattaa 2484781 aaaagccgat gcccggcatt cttggcgcgt tcgccaaagc agctttctgt tcatgcggca 2484841 gcggtgtagc caggtcccac ccttctccaa aaagcaggat tccgggcttt gccttagttg 2484901 ctttctcttt catataaagc acggtgtcaa tatctaaaat cccgaggaga tcaaagcgga 2484961 agccgtcaac attgtattct tcaagccaat agaccacgca atccgcaatg aattttcttg 2485021 ccatccttct ttctgatgca atatcattgc caacgccggt gccgtttgat ggcatcccac 2485081 attcgtcgtg ccggaaaaaa taaccgggca ctgtcttttc aaagggggaa ttctccctct 2485141 tatacacatg gttaaaaaca acatccagaa tgactcgcag accgtgctga tgcagggtat 2485201 tgatcatttg tttcagctct gtttttctcg tttgaggatc atgaggattt gaggcatagc 2485261 ttccctccgg ggcaaagaaa tgaagcgggt tatatcccca attgtatgca tcaagcggct 2485321 tctcttcatc aactccggca aaatcattca ccggcagaag ctccacatgt gtcacaccaa 2485381 gctcttttac atacgctaat cccgaagaac tgccatttgc ggtttgtgta tcagtttccg 2485441 tcagcgctaa gtattttccc ttgtttatca tgccgctgtt ttcatggatg gagaagtcgc 2485501 gaagatgcgt ctcatagatg acggcatcca cagggtgtga gaatggttta agaggagcag 2485561 tccatttcat ttgatccggg cgcaagacga cgcccttctc tccatttaca gtcacagcct 2485621 tggcatactg gtcaactgtt tccatccatt ctgaattgtt gcagatgcaa aacaaatact 2485681 catatccgtg aaggtcacct gtgaccgtga cggcatagac gcctttttcc aagcgagtca 2485741 tttggaatgt gcgcccgctt ttattggggt gtgaaagctt gacagcagct gaggttgcag 2485801 caggcgccca tactttaaat acggtatgat ccgcggtata aacggcgccc agctctccgt 2485861 cataataaaa ttcgtcatca aacgctgccg tccggatgac cgcgccaatt tggagatccg 2485921 ttttgtggcc gctggatgct ctgacgcaat ggatttttcc aaatgtcaca ggatggtcgg 2485981 atacgcagac gtacttgtat tttgcttcaa gggagtattc ctccctgaca gccagaggaa 2486041 aatctgttat ttctgtctca agccgaaacg gcggtgtcat gatttccttt tgttcagcag 2486101 gaatcagaac agtaatgata ttcatgtcat cgacatacgc ttcgaagctg cggcggatgc 2486161 tgaccatcgg aagctctctc ctccaaacac gtttatgttt tgattcttag gggtgaagga 2486221 ctagatgcca gacgaaacgg ggtagtgccc atgatttctc cgtcagcatg gaacgggatt 2486281 ttgtccttcg tgtaaaatgt aatgtccttc gctttaaaca tcgtaacgcc atccatcttt 2486341 gtatgttttc caaatgccat gagacataaa agccaatatt ttttcaaaaa cggctggttt 2486401 tcaacgatta cgatatcaaa tgtcttctcg cgcggatttg ctaggggcgc cgccttcatg 2486461 cctcccccgt aaaacggatg gttggataca acggcaaacc agacatcatg aaattcgcgc 2486521 gtctcgtctt ccgtcgtaca agctaatgta aacggcttaa aggttgccga agcgtgcaaa 2486581 tgagaaagcg gatacacaag aaatcgaagg cggagaaaaa gaaaaacccg tctcaacgga 2486641 aattccatcg cctttttatt gacatatgcg tcaaacccga tcccgatatg attcataaaa 2486701 taaagaatct gtgatttatc ctgaaggaaa ttgacgctcc ctaaatgaaa ggttcttgtt 2486761 aacgggcgct ttaccttctt gatttcctgt atcagatcga tttttttaat agagaaccct 2486821 cgcgaaaaat cattatacgc gcccgccggc acaaagctca gctcaatatc gtcaacatct 2486881 ttcagcccgt tgacaacttc atgcatggtt ccgtctccgc caatgacgat caggcgcttc 2486941 agcttatatt cctgtatcgt tgaaatctgt ctggcgagca cctcggcgtg tcccggatgt 2487001 tcagttaaaa atgaacggtg ctcaaccttt cgtttgatca attctttttg aatggacttc 2487061 caaacacgca ggccgtttcg atgtcctgct gtcggattaa taataaaaaa ccaatggctc 2487121 atctttctca cctgcttatg ttatgagaaa accgctcaaa tcgttctctt ttactccagc 2487181 cactcctgtc tgcgatagga gtcagacatg cagtaagaca atagagcctt tgcagccttt 2487241 acctgatgat gtttgatcgg agcagtgttt ttcttctgcc gctcaatcca ttcttccgcg 2487301 ctccgcttat ccgctatttc taagccgtat ggcggctccg ggtaatcgat gtacgacgtt 2487361 ctgctcagaa gcaattttcg aaccggaatc tcagcctgtt tttcctttac gatctttgac 2487421 acaaccgagt ccgtacgaaa caggctaagc cctggattta acactgatgc agtctgagag 2487481 gctgttttct tgtcccaaaa acgattttta gaccctatgt agacactgtc ttcctcagcc 2487541 tctaaaaaag aaacgcaata aatttccaga ggagaaataa tcacaatgct taattcaacc 2487601 gccgcctgct gaattttcag cacaggctta tacataataa aataagaatc aggcagctgc 2487661 tgggtcagat aacgcaaaat gcggtcctgc ttcacttggt ttgagagttg agatatttct 2487721 gaaagagtag agcttgccca tttgagctga aaatcatata aatgcctttt ataaaaagaa 2487781 gcaagcgcca ccctgctctt cgggagcctt acatgaatat cttcttcgtc ctcaaaccat 2487841 tggtgtctct cttcttgtat atcggctttt atctcttctt ttcttctttt caatgaaaat 2487901 ttttttcgtt tctgcaccgg ttccggttct tcagcactgg cttgcctttc ttcatgctgg 2487961 cgctccgctg cttctactag tgaaagccag cgctcttttt tcaaacgtac aaactggttg 2488021 atataatggt acggatcaag ctcatatctc gatatataat catgaatttt gatgatttgt 2488081 gccatgtttg tttctccact ccgcaatgaa ttaagataat tgaaatttga atatttcctc 2488141 gtattttggt gattggttca agtgtatttg aaagagcgaa aatcgttcag ccatcatcga 2488201 aacctcgccg ctttcaaacg gaacatgagc tggaaatcca tcttcgcctg tccattttct 2488261 tgccagcgtc atatgaggat gatacggtct tttttccact tgaaagccgg cctgaagtac 2488321 agcctgcttc gtatgttccc gcagtctatc aagcgttttg tttttctttg gctccagatg 2488381 taaaacgcgc ggctttctgc ggtcgccgaa tacatctatc ttgccaaact taattgaaaa 2488441 tggatcaatt tctgaagcaa tctctgctag cgaaccttca agcttcttta tttgtgtctc 2488501 atccgccgct ccgagaaaaa ttaacgtgat atgatagtca agcgggtgca cccatttttg 2488561 aaacgtcaat atcggttcgt ttttcgcagc ctggtagatc ggatttgcaa ttccctcagg 2488621 tatgggaacg ccgatgaaat aatgaggccg tatatctggc atccgtctga cactcccttc 2488681 tttgacagct attattttat caataaagag gctgtgcgga tagaggaaca gtgtatgaaa 2488741 acactctcgc acaaacgttt attatgttag gatattatat gacacttgtt ttattcagaa 2488801 aggaatgaca atgttgaaaa tcgttgcaaa cacagctgat ctgataggag atacaccgct 2488861 agtgagattg aatcggcttc agccggaaaa tgcggcacaa gtctatttaa agcttgaatt 2488921 tttcaatccg agcggcagtg tgaaagacag agccgcttat caaatgatca tagaagctga 2488981 acaaaacggt ttactcaagc cgggatcagt tattatagag ccgacaagcg gaaataccgg 2489041 catcgggctc gccatgaatg cggcagcacg cggatataaa gcaatcttag ttatgcctga 2489101 tacgatgacg aaggaacgga tcaacctact taaagcttac ggtgcagagg ttgtattaac 2489161 tcccggagag gaaagaatgc cgggcagcat caaaaaagcg aaggagcttg ccgaacaaat 2489221 tccgaacagc tatattccaa tgcagttcga taacactgct aatcctgatg cgcaccgaaa 2489281 aacaacagcg cctgaaatcg cccgggcaat agaggaaatc ggaaaaccgc tcggcgcttt 2489341 tgtagcctcc tctggaacgg gcggaaccat taccggaaca ggtgaggcgc tcaaagagct 2489401 ttttccggat atcacggttc atgttgttga gccagcgggt tcgcctgtat tatccggcgg 2489461 aaaacctggc gcgcataaac ttgtaggaac gagcccaggc tttataccgc cgattttaaa 2489521 tgaagacgtt tatgatgaaa ttatcaaaat ctctgatgaa gacgcgtata cgacgacaag 2489581 acggcttgct gctgaagaag gaattcttgt cggtccttca tcaggcgctg cctgcttcgc 2489641 ggcaatcgaa acagcgaaac gcctctctcc tgacaaagtt gtggtctgca tgacagctga 2489701 tacaggagaa cggtacttat caactgattt atggtcattt atttaaaaaa aggactggct 2489761 tcagcagaag ccggtccttt tattttgcaa gctcgtaaat ggcctgagca tataacgctg 2489821 tcgatctcag caggtcatca atttcgatat attcatcctt ttggtgtgcg ctgtcagggc 2489881 gtccggggaa cagcgggccg aacgcgacac cggcttttaa ggatctcgca taagtccccc 2489941 cgccgattga gattaaatca gcttttttac ccagctggcc ttcataaacc ttttgcaggg 2490001 ttttgactaa cggatgatct gcggacacgt gatgcggctt gctgtctttg aattctccca 2490061 gctcaaattc agatgcgctt tcgaatgtat cgcggatcac tttgctttct gctgtcacag 2490121 gatagcggat attgatcccg agctcgcctc cttgcccttc tttatagcgc agtgttccga 2490181 catttaatgt cagctctccg ctgatttcat cctcacagtc gatgtccagt ttttttcctc 2490241 ttgtatcacc tgagaactta tctgtcacaa cttgcacaaa ccgctttcct gcatcgtcaa 2490301 gctcagtctg ctggagaaat tcgcacaata aaatgccggc attgatccca ttgttcggtt 2490361 ccatcgcatg gcaggaaaga ccgtacatac gcaaaatgag ctgtccgttc tctattgcag 2490421 cttccccttt ttggtccgtc gtgcggagca tgtctttaaa tgaagacaga atctcttcat 2490481 ttttcggccc ttcaatgaca gcttccgcag cgtcgggcac catgtttaag cgaaggcctg 2490541 attgaaacga gacaagcact gcctttggtt cagcttgatt tgggcggtgc ggaataagta 2490601 aagaagcatc gatgatccct ttttccgcat taatgatcgg aaaatcggcg tcaggcgcaa 2490661 agcccattgt tggcatttct tcatgcttga aataatgctc tacgcatctc caatcacttt 2490721 cttcatctgt tccgataatc attctgactc gcttggacag gggcaaattc atgtctttca 2490781 cgattttcag cgcgtagaat gccgccattg tcgggccttt gtcatcaatg gcgccccttg 2490841 cataaatccg tccgttgcgg atttcagctg aaaatggatc actcgtccac ccatctcccg 2490901 gcggcacgac gtcaacatgg caaagtacgc cgataatgtc atcgccctcc ccccattcaa 2490961 tatgacctgc gaagccgtca agattttttg ttgtaaagcc ttctttttct ccaagctcca 2491021 gcaatgaagt caggctggca tttacccctt ctccaaacgg tttaccgggt ccggcggttg 2491081 tttcgtccat gacactgttg attctcaaaa attcctgtgt atcacgaatt aaatcctctt 2491141 tttttctgat cacttcaact tcccagttca taatgatccc ctttccgcaa gaaatgactt 2491201 gcaaaaacca aataaaacga ataatattaa tggtgttttg ttaaaacgtt cgtaattgga 2491261 ggatactatg tttcatctaa aagagcagca aacatccata aagcaagaaa tcatagcagg 2491321 gctgacgacc tttttcacaa tggtctatat cgtcgtggtc aatccggtca ttctggctaa 2491381 cgccggggtt cctttcgacc aggttttcac cgcaacgatt attgcctcca ttgtcggaac 2491441 gctgtggatg gccctggcag caaattatcc gattgctatt gcgcccggca tgggcttgaa 2491501 cgcttattta gcctttcatg tcgtaagcgc aagcgatggc ggcatcacgt acgcaacagc 2491561 tttcagcgca gtatttacag caggggttct cttcattatt ctatcgttaa cgcctttaag 2491621 aaaacaactt atagaagcga ttccaaacaa tttaaaatac gggatcacaa cagggatcgg 2491681 gctgtttatt gcttttatcg gtttgcgtca agcgggaatt gtggcagctg atgagtcaaa 2491741 cctggtcact ctcggcaatc tgcattcacc tggtgttatc ttaacgctgg tcggcctttt 2491801 gatcagcgtg gtcctgatgg tgctgaatgt aagcggcgct ttatttatcg gaatggcagc 2491861 taccgctttg atcgcctttt tcaccggtca gctccatttt tcaaagggat ttatgtcgct 2491921 tcctcatttg ccggaaggat tgatgatctc aaatccattt accgcttttg gcgatgtcat 2491981 tcatcacggc ctgtacgctg tcgtcttttc ttttctatta gtcaccattt ttgatacgac 2492041 aggcacgatg atcggagttg ccgagcaagc cgggctgatg aaaaacaaca agctgccgaa 2492101 cgtgcgaaaa gcgctgcttg ctgattcaac cgcgacgaca gtaggagctg ttttcggcac 2492161 aagtccgacg actgcattta tcgagtcttc cgccggtgtc gcagccgggg gaagaacggg 2492221 gcttacggct ttgactgtcg cggtgatgtt tgcggcttca atgtttttca gtccgcttgt 2492281 cagcgccttg tcaggtatag ccgccatcac ctcgcctgct ttgattatcg tcggcagcct 2492341 gatgatgggc tcagtttcca atatgaactg gaaagagatg gacgaggcat ttcctgcgtt 2492401 tctcgtcatt ctagccatgc ctttgacctc gagcatttct acaggaatcg cgcttggctt 2492461 tatttcgtac ccaattgtaa aagcggcgcg gggaaaatgg agagagattc atccgctcgt 2492521 catcgttttc gccattctgt ttttcatcca gctgtttatt ttataaggat agaccaaaaa 2492581 acccaaacgt cgccgtttgg gttttttatg taaacaataa agagacagcg gccgctaaaa 2492641 aacaacaggc ggcaaacgca tagtgcagga tgttgataca gctttttctg gcccgataat 2492701 attcatcact ttccttatcg gtgccaatta aaaaaggggc atccatgacc ttgtcaaaaa 2492761 taagcgtcag gatataacgg caaacccctg tgtataccag cagcgcaatc accttcagcc 2492821 aaattgggga aacaaatatg agaacagtga aagctgacag tagcatgtac atctgccttg 2492881 catactcgcc attcctcagc ataactttaa aaaacaactc cttatagcct gtgcagatcg 2492941 ttcgtctttt aaatatcctt tttgaatttc ggtataataa tggttttctt ctcatcctgt 2493001 cttttacttt tggcattccc gcctcctgac tcatcatcat cacaagtcct gcaagggcaa 2493061 gcctgctttt tttctcttca gtcacctcag cttcaaaagc cgtgaacgag gctgtctttt 2493121 tcaaactgcg gataactgag aaaaacaaaa ataaaatgcc aaaaagcgca agcaagtgcc 2493181 gctcagtaaa aacaatcagg atagcagaac cagcaaaaag aatagctctg acaagggtat 2493241 cgccaatcca tctcgaaatg gagcgcggct ttctgatcct gtcttgcttt aaggataaaa 2493301 agaatatatg aaggccaaac aaataacaca atagagcagt gctttctgcg aatgtgatga 2493361 gaacagaatg actgatcaag ggaaggacaa tgaaaaagag aagcagccat ttagccagcg 2493421 tggccagaaa agaatacaaa agcgcatacc gtttgagctg atagatgatt tccttctttt 2493481 gcagcaaaaa cactttgtcc gcttccatta aaaatgtacg aatcgaacct gtaaacatga 2493541 tcagcacaca cacagcatac agccatctcc attccgccac ttcagaccac tcataaagaa 2493601 ggcctcttcc gttcatcaaa tcaatatact gatagatgac aaaagcaatc gccggcaaaa 2493661 cgatatagag agcgactgtc cagtcaatga ccgcatgcaa cactttaaac tgatacttat 2493721 aatagtcaaa cagccttcga aaaaagagcg tacgcccgtt catagccgat caccttgaac 2493781 tgccttataa aaacagtcaa gcaatgactg cccctctaat ccggtcttgt cctgaacatc 2493841 ttttaacgtg ccttggagaa ataatgaacc tttctcaatc atataaaacc ggtcacagat 2493901 tttttccgcg gtatcgagta catgcgtgca cataagaatt ccggctccac gttctttttc 2493961 agccttaagc atgtccacaa agcgtttcgt cgatatcgga tcaaggccga taaacggttc 2494021 atcaatcaca tacatatccg gcttagagag aaaggcctgg ataagcatta gtttttgctg 2494081 catgcccttc gaaaaggtga caggcagctc atgtttgaca tgatctagcg aaaacgtctg 2494141 cagcaggctt tgggcccgat gcgcaaattc actctcttca atgccgtgaa gtgtgctgat 2494201 cagatccaaa tgctcccaca gcgtcagttc ttcgtagaag gacggatgct ccggaatata 2494261 tgcaaatgaa cagtcgttcc aggcaatatg ccctttaaaa tcttctgaaa ggccgagtat 2494321 cgccttgatt gcggtgcttt ttcctgcgcc gttagctccg atcagtccaa ccagttcccc 2494381 ttttctgact tccagaaaaa catcggtgag cacttttttt cggcttgtat acccggcctg 2494441 ttctattgaa gcttcaagca aatttgtcaa aactcactca cctccaaaat ttactacgaa 2494501 atagaataaa aaaagtttct ttaaccataa taatattgag ccgaaataca tagtaatcca 2494561 acaaggatgg ctgcccaacg cgaaattgga aaaaattaat aggagttatc cctagattca 2494621 tcactgcaat atcgtgtata atgagggcga attattttaa caattacaga tgtctgcctt 2494681 tgttgctatt tcgtacgcag ttgatagtcg tgagttgtgg ttagtcaagt ccatccgatc 2494741 ttatgatagg gagtggtttt ttgaaacctt caacaaaccg tatgctaact cgaatcaaat 2494801 cagtttacat gtttattcaa gaaaaaggtc ttgtgacaac acaggaactg gttgacgaat 2494861 tcggcattac acctagaacg attcaaagag acttaaatgt gttggcatat aatgatcttg 2494921 ttcatagtcc aagccgtggc aagtgggaga caacgagaaa gaaagtaaag attacctcat 2494981 aaattgaaaa ttacataggg ccgcctgaga gcggtccgat agataacagg gcgaagaaac 2495041 tactgagcct tgtttttgtg tgcttataaa taaaaccccg cattcggtat gcggggtttt 2495101 tgtcatgctt gcggctcatt tagcaaatga agctcttcct ctgtcagctc acggtattct 2495161 ccgggtgcca gagcgggatc tagggaaacg cgtcccatcg aaagccgctt cagataaacc 2495221 acttcattgc cgactgcctt tgccatttgc ttgacctgat ggtattttcc ttctgtaatt 2495281 gtcagatata taacggtatt gccactgtcg tttgttttga tttccgcttt tgccggcttt 2495341 gttttatagc cgccctctat gtagacaccc gtttccaaat cggaaatgtc ttcccgagaa 2495401 atctgtgatt ttaaatggac ttcatacgtt tttggaacat gctttttagg agaaaggagc 2495461 cgatgtgcga gctggccgtc atttgtgagc agcaaaaagc cctctgtatc tttatcaagc 2495521 ctgccggctg gaaatggctc aaatctcatc tcctccggcg tcagcagatc gaccactgtt 2495581 tgctgccggc tgtcctcagt cgccgacagc acgccctgcg gtttattcat cataagataa 2495641 atgaactctc gataatcaac cggttccccg tatacggtca cctcctgcgt atcaggatca 2495701 acgtgctcct ttacatcttt ggcaggtttg ccgtcgatca tcacggctcc agccttcaca 2495761 acggctttga cttcttttct ggaaccatac ccgctgttgg caagcagctt atcaagtctc 2495821 attcccaatc tctcctttat aaaagaaagc ccgcagcatg cgagccctca gtttcatcat 2495881 atctagttca tcagcctgca tgtctgcctt tcctaaagaa acctggcaaa cggcggccta 2495941 aaattttctg caaaaatcct aatcggtagc cgcaatacag gtagacagct ccgccaacag 2496001 cggccgcgat caccacaaca atcgcagctt gcatctggcc atcctgatag gaaataaaga 2496061 agcctaatac ccactgcacg attttcacgg caatacccat aatggctgat aagaccagca 2496121 tcaaaacagt tcgtttaaca agtatcttat acgaatagcc tgcatggcgc ttaatcatga 2496181 taaacccata taaaagggaa gcgatatatc caagcgccgt cgctaaaatc gctccgtcag 2496241 cctgcatcag cttgatcagc ggaacattca gcacaagctt gatcacgaca ccgatcacaa 2496301 ggctgacaac cgcaaatttt tgcttattga tgccctgcag aatagctgcg ttgactgtaa 2496361 acaaagagaa cagaattgcg acaggcgaat accaaagcaa aatgtttgcc cccagttcag 2496421 gatgaaggct ctctgacccg taaaagaacg tatacgtcgg tcctgacaat agagagatcc 2496481 cgacaacagc cggaataatt aaaaacagga tcgtctgcat cgtttgatta atctgctgat 2496541 ttaacagctt atagtttccg cttgtaaacg attcagtaat cgttggaatt aatgtcagtc 2496601 caaaagcagt tgctagggaa accgggatca tcacgagctt ctgaacatac agggttagaa 2496661 tcgcaagcat gtcctggctg atggcttgat gaccggcttc aatcatcgct ttgttaaacg 2496721 tatttgtatc aatatagtta tacaaaggga tggctagtcc gacaaaaacg tacggagcag 2496781 catagctgaa cagctcgaaa aacattttct tgtagcttag gtttgctgtc ggacccgtat 2496841 tcggcatcat cgccagcagg ctgcccttcc gtttgttcca ataaatataa agcacgacca 2496901 gccctccgaa ggcaccgatc agcgctgcga aggttgcata gcccacagcg atgacaaggc 2496961 cgccgttgaa aaccttcaaa atcaagaatg tcgcactcaa tagaaagatg atgcggacaa 2497021 tctgttcaac gacttgggaa acagctgtcg gacccatcat ttggtgccct tgaaagaatc 2497081 cgcggacaag gctcataatc ggtacgacca aaagcgctaa gctgaccatg cggatgacat 2497141 aaacgacatg atcaattgtc aggccgttat tatccttgcc tcccagcgat atttccgcaa 2497201 acatcggagc cgatagatac agaatgaaaa aggctatcat tcctgtgact agcataaccg 2497261 acatgcccgc cttgagcatt ttcctgcttg tctcataatc cccttttgaa ttatatttgg 2497321 aaacaaattt agaaacagcg gccggaaagc ccatcgtagc aatattcaaa aataaagtgt 2497381 attggttgta tccgtattga aataatgcac cgcctgtcgc cccgaccata atgctgaagg 2497441 gaattaaata gaccatcccc agaatccgcg atatatatgt accgagcgtt aatacaaacg 2497501 tgcctcttaa cagtttgctt gacatgtttc ttcatcacca ttttctacga agattcaact 2497561 tttctatttt accacaactg ggcatttaga cggtaataaa tacaaaagca atcctgtgaa 2497621 cattcatgtc cgcggcaaaa gacgtttaag gagcggcttt ctttcgctat aatagtactg 2497681 cggacgggtg tccgcacacg aaatgaaaag aaagttgatg ataaagatga aacaatatga 2497741 cgtaatcgta atcggcggag gcccttcagg cttgatggct gcgattgcag caggagaaca 2497801 gggcgctggc gtgttgctga tagataaagg aaataaatta ggacggaaac tcgcgatttc 2497861 cgggggcggc cgctgcaatg tgacgaaccg ccttcctgtg gaagaaatta tcaagcacat 2497921 ccccggcaac gggcgttttt tatacagcgc gttttctgaa tttaataatg aggacattat 2497981 caagtttttt gaaaacctcg gcattcaatt gaaggaagag gatcacggcc ggatgtttcc 2498041 tgtgaccgac aaagcccaaa gtgtcgttga cgcgctgtta aacaggctaa agcagctccg 2498101 cgtaacaatc agaacgaacg agaaaattaa atctgtttta tatgaagatg gacaggcagc 2498161 agggattgtg acgaataatg gcgaaatgat ccatagccag gcagtcatta ttgctgtcgg 2498221 cggtaaaagc gtgcctcata ccggaagcac gggagacggc tatgaatggg ctgaagccgc 2498281 gggccatacc ataacagagc tgtttccgac agaggttccc gtcacttctg gcgaaccgtt 2498341 cattaagcaa aaaacacttc agggcttatc actaagagat gtagccgtca gtgtgttaaa 2498401 taaaaaaggc aaaccgatta tcacacataa aatggacatg ctgtttaccc atttcggcct 2498461 ctcaggacct gccattctca gatgcagcca atttgtcgta aaagagctga aaaaacagcc 2498521 tcaagtgccg atcagaatcg acttgtatcc ggatatcaat gaagaaacgc ttttccaaaa 2498581 gatgtataaa gaactgaagg aagcaccgaa aaaaaccatt aaaaacgtgc tgaagccttg 2498641 gatgcaggag cgctatctcc tattcctgct cgaaaaaaac ggcatctctc cgaacgtatc 2498701 gttttctgag ctgccgaagg atcctttcag acaatttgta agggactgca agcagtttac 2498761 tgtcctcgca aatggcacac tgtcgcttga taaggcattt gtcacgggag gcggggtatc 2498821 tgtaaaagaa attgacccga aaaagatggc ttctaaaaaa atggaggggc tttatttttg 2498881 cggtgaaatt ctggatatcc acggctacac aggcggatac aatattacct ccgcccttgt 2498941 cacaggcagg cttgcagggc taaatgccgg gcaatacgcc cgttcttaat cattactctt 2499001 taaatctctt gccgccaaac tcacatttga acattccccg cattcatgtt agggtgagac 2499061 ttgttttgtt tcacctgatt gcggggtaat tttaagagag gaatgagctg ccatcgtacg 2499121 accatactaa gcctgcgagc aagatatagg cgtacacaaa aaattagagg gtgagaaatg 2499181 ttgaaacata tatctagtgt attttggatt gtgattgcaa tcacagctgc agctgtatta 2499241 tggggtgtta tttctcctga cagcctgcaa aatgtgtctc aatcggcaca agcatttatt 2499301 accgattcat ttggttggta ttatctttta gttgtctctt tgtttgtcgg gttttgtctc 2499361 tttttgattt tcagcccgat cggaaaaatc aaactcggaa agcctgatga aaaaccggaa 2499421 ttcgggttat tatcatggtt tgccatgctg ttcagcgcag gcatgggaat cggcttagta 2499481 ttctacggtg cggctgaacc gatcagccat tacgcaatta gctctccatc aggtgaaaca 2499541 gaaacccccc aagccttcag agatgcactc cgctatacgt ttttccactg gggtttgcac 2499601 gcttgggcca tttatgccat tgtggcatta tgcattgcct atttccaatt ccgcaaaggc 2499661 gcacccgggt taatcagcag cacactgtca ccgattctcg gggataaagt aaacggaccg 2499721 atcggaaagg ccattgactg tattgcagtt ttcgccactg ttgtcggggt gtcaacaagt 2499781 cttggtcttg gcgcaaccca aattaacggc ggtttgaatt acctgttcgg cattccgaat 2499841 gcgtttatcg tccaattggt tttaatcatt attgtgacag tgctcttttt actttctgcg 2499901 tggagcggac tcggaaaagg aattaagtat ttaagcaaca caaacatggt attggccgga 2499961 ttgttaatgt tgtttatgct cgttgtcggg cctacagtgc tgataatgaa ctcatttaca 2500021 gattctatcg gacaatacat tcaaaatatc gttcaaatga gcttcagact gacaccgaac 2500081 gatcctgaaa aacgcgaatg gattaacagc tggacgattt tctattgggc atggtggatt 2500141 tcctggtctc catttgtcgg cattttcatc gcccgtgtat ccagaggccg gacgatccgc 2500201 gaatttttaa tcggcgtctt ggtgacacct tgtattttga catttctatg gttctccatt 2500261 ttcggcgtat cagccatgga tctccagcaa aaaggcgcgt tcaatgtagc aaagctgtcc 2500321 actgaaacga tgctgttcgg aacacttgat cactatccgc tgacaatggt gacatcgatc 2500381 cttgcattga ttctgatcgc agtattcttt atcacgtcag ctgattcagc tacattcgtg 2500441 ctgggcatgc agacgtcgta cggttcttta aatccggcga attctgtgaa actcagctgg 2500501 ggtatcattc agtccgccat ggcggctgtg ctcctatatt ccggagggct tgccgctttg 2500561 cagaacacag cgattctggc agcgctgccg ttttctatcg ttatcctgct gatgattgcc 2500621 tctctctatc aatcgctctc aaaagaaaga agagagatca aaaaagcgga gaaactcgat 2500681 aaaccaagaa gtccaagagt gaaaaaagca tattaacaaa aaagatcttt ccgcgcctgc 2500741 ggaaagatct ttttatttgc gatataaaat aagggcggaa aaacagtaaa gctgctcgcc 2500801 gtctgggtcg cacgccgccg aaaccgtata tttgatatct atcagctgct cctccgatat 2500861 cccttttaaa aatgaattga tttccgtttg taagtctttt tcatgctctt catcaaatac 2500921 cgctaccttc agcattttat ccgctctcct ttctctatca atctattccg tttggaacag 2500981 cgttatgata gagaaatgat gattatctcg tttccggata aaaagctttc cgtatatggg 2501041 atttcctctg tggctcgccg ccgtgctgct ccactttcag cagcacggca taaacaatgc 2501101 gcatatggca gtagctgata aggctgacgc tgaaaaaagg gacaatgccc ggcaggtacg 2501161 caagcaagaa aaagagagca acagtcagcg caagcatagt aagcgtatat tgcaaatacg 2501221 ccacactgag caagagcgaa aatttcacat acagacgttt tttccagtca aaatggacaa 2501281 gcagcggaaa cacataaaaa agcatggata cgaacaaaaa gccaaatatc ataatggcga 2501341 agcgcaggat gtgcagaagg aaatgacttg gataaattaa ggccaaatca atataaatga 2501401 tcactccgat gagcgccagt acagcgccga gcagatttga acgaaaaaat tcacccttgt 2501461 attcctgcca aaacgttttg agcaccggaa cgttgtcctg cccctggatc cacttccgca 2501521 tgacagcgaa taaagccgcg gtcgcgggca tgatgccaaa cacgccgaga ccgagcaacg 2501581 taaaaaacag ccacagcaag tttgtatacg caaatctcat aatccattcg caaaaacgca 2501641 gcatccgtcc cagtgagcca tcatgttcca tggcgccccc tccttttttg cattatacat 2501701 tctgcatctg aaaaagctct ttcatgccga tcggcttctt ttcggcaacc gagcgccaca 2501761 ttccctcacc aaccgcgatg gagtaggctc cagcttcagc cccggctaaa atatcatagc 2501821 ggcgcagcgg gtctttccct aaaaaaagat cctcaagcaa aagcggatca cctccgccat 2501881 gccccccttc atttttgacc acttgtatcg tctgctttga ttcaaaaagc ggatagtatt 2501941 cgattgtctg ctcaggaaaa gcaaacggaa ttctggaagg ttcgtgaaat tcatttgatt 2502001 caatacgtcc ttttgtgccg ttgatcgtca gccggtagcc ttcatacggg gccgaaaaaa 2502061 taatcgagta gcttaacagt gcgccgccat catatttgac tgccgccacg tacgtatcct 2502121 cgatgtcaat ttcctcgtca aaaatacacg cgtcaggcct gtatgcagta tataagctgg 2502181 actggtctcc tgcttcaaga tgatcatcct ttatagaagc tttagaggaa cggggatgcc 2502241 accttgaata gtagtggcat ttttctttaa cacggcacgt cccgcaaaaa cgcccgtctt 2502301 cttccggcaa ggggttccac tcactgtccg gcccatagta attcaaggcg ccataagcaa 2502361 atacctcttc cggattttgc ccgagccacc aattgacgag atcgaagtga tgtgttgatt 2502421 tatggacaga aagaccgccg gaaaactgtc tcgacctgtt ccagcgttta aaatagctgg 2502481 cgccatgata cgtatcaata taccaattta aatcaacaga agtgaccctg cctatttttc 2502541 cgtccagaat catttctttt attttccgat gaaacgggct gtagcgatag ttaaacgcga 2502601 cggtgacttt tccttcgctt ttggcctccg cttcaagcac ccgattcgca tcctgcactg 2502661 ttgtcaccat tggtttttca gtaatcacat ctgtattcca ctgaaggctt tttacaatat 2502721 atgcgacatg cgtatcgtcc ctgcctgcca caatgacgat atcaggcttt gagacgcgca 2502781 tcatctcgtc aaaagcatct tcgctaaact caggcacgtg ggccagctcg ggaaatttct 2502841 tcttgcaaac ggcaaaacgt ttcggatcgg catccagcaa tcccgtaatc tcataatgag 2502901 ttgaaaaccg ctccatcagt ggtttgataa acatactgaa tgctctgctg ctcaatccgc 2502961 aaaagacgat gttcttcaat atcctcacct ctatcgggct tcagttagtt gagaaatcag 2503021 ctgcagcgct tcctctgttt tttcagcata cacagggata aacgccgcca tatcgcgatt 2503081 caattgaaaa gaatagccgt tcagctgttt tttccctttt tcgatctgaa cggcatagat 2503141 cgttttttct cctgtttttt tattaacagt tgtataagga gatgtttttt caggaggcaa 2503201 tccgtttaac ggctgaaaat tttccggatc atcgtaagct tgaaacatgt cttcaggcac 2503261 gatgaaaaca tctccctcat gggcggtaat ttcagtcagc agtttttcct gaaaagctgg 2503321 aaagatatcg accttcccgg cattctgctc ggcggccttt tttatttttt cctgtacgcc 2503381 agcctgcata tcagaaaaga gaatgacatg cattccgtcc ggcctgcttg agcatgatgc 2503441 caaaaagagc actgagacga tcacacacaa agccgtacgt atcctttttg tcatttcccc 2503501 gctgacctaa aaagaggctc cagctctgtc atagctaaaa taaacgcgcc ggctccgtgc 2503561 agatcgtttg tgcttctttc gcggctgaca taatagtcat agaaaccggc tgacgttccg 2503621 acacatatgt ctttgacgag aaacgctccg tcttctgatg tttcggtttt atgctgaatc 2503681 aagccttgat acgcttttag cagtgttgtt tcgtaagctc tgtctagata gcctttattg 2503741 attccttttg cgattgcgta catgtacaga caggatcctg agctttccag ccagttatca 2503801 gacctgtctc ccttatcaac gatctggtac cataaccccg tctctttgtc ttgatagcga 2503861 cagatgcttt taatcatgtc ctgcagcgtg tttttccaca catgacggtt cggatgcttc 2503921 ttcggcagct cttcaatcat gtcagcaaga gacatgacgt accagccgat ggaacgtgcc 2503981 caaaattccg gtgaacagcc tgtctcttca ttggcccaag gcattttttt cgcttcatcc 2504041 caggcgtgat aaaaaagtcc ggtttttgca tccttcgtat gctttctcat caatgactcc 2504101 tgaagcacaa cctgatcaaa cagctccgtc tcctgcttca gattggcata tttcagtgca 2504161 aacggccccc ccatgtataa gccgtcaagc cacatttggt aaggataacc gtctttgtgc 2504221 caaaaaccgc cctcagacgt ccggttcagt gttccatata agctgcgcag cctttttgcc 2504281 gctttgacat accgttcatc cttcgtctgc tcgtataatg gaaaaagaat gagacctgct 2504341 tgaatggcgt ccagttcatc tcttctaaat aatagattgc cattatcatc gattaagaga 2504401 tctgcataag ccttcgcata ctcaaaatac cgcttttccc cggttgcttc ccacagccgc 2504461 aatacaccgc ataagaaaac accctgatgg tagtgccagc ggtttgcagg tggcagctcc 2504521 tcgactgtgt acgtgttcat aatggtgttt gccaatgcct ccgcgtacgt aagaggcgat 2504581 tttacagcga ttgattgatc cattgatccc atccctttcc taataaattc cttcctcgcc 2504641 aaatttcttc gccaaacgat tcgctagcat gaccaaaatc agcccgaccg ccgctttaaa 2504701 tacgccgact gctgtactgt agctgaattg gccctgtttc agccctgcag tataaacata 2504761 cgtatcaaaa atttccgcca cttccctgtt agtcgcattt aacagcaaat acacatgctc 2504821 gaagccaagc tccagcgtgt ctccgatttt caaaatcagc aaaacgacga taacgctttt 2504881 aatggcgggc agcgtaatat gccacatttg ccgcagccgt cccgctccgt ccattttcgc 2504941 cgcttcatac agctgggggt caaccgctgt aatggccgcc agataaatga tcgtcgacca 2505001 gcccgcttcc ctccagataa cctgcagaat atacaggggc cggaaccatt cttcgttcag 2505061 cagaaaattg attttttcac cgccaaaaaa cacaatcagt tcattaatca agcctccgtc 2505121 taccgttaaa agcacaaacg aaagcgatac aacaatgacc caagacataa aatgcgggat 2505181 ataaatcagc gtctgaacaa attttttaaa gagagcaatc cgcacttcgt tcaatagaag 2505241 cgccagcagt atcggcaccg ggaaaaatat ggccaggttc aaagcaaata acacgagcgt 2505301 gttttttaac aagagaaaaa atgtaggctc agtaaacagc ctgataaaat gcttcagccc 2505361 cacccactca ctgcccaaaa tgccgaggaa cggctgataa tcctgaaacg caatcacaat 2505421 tccccacatc gggacatact taaaaagcaa aaaataaata caccccggca aaatcatcaa 2505481 gtacaaatat ttttgttgaa tcagcttgat tagtaagcgc tttctttttt cttttttaaa 2505541 aatgactgca tcaacagccg gcgcttgcgc ttctgctgtt ttcatttttt cctagcctcc 2505601 tttcacggat tcttgcattc actgtagcgc agcaggcaaa agtccgtcta caatcatatg 2505661 atcacatcct gttttatccc tttataatca agggttcagc cggtccacct gaaaaaaaga 2505721 caccgatatt agaaaatgat tattgacaat atctatcaat ctttggatta attgtattaa 2505781 ggtgaagtgg atgttatgaa atggggggtt ttatgaaaag aagccaatac aagttttact 2505841 acaaactgat cacgtttttc tgcctgctca gcaccattcc ggttattttg gtcggattat 2505901 tttcgtacga gcactctcag aaaacggcta tttccaacgt ttcggaggaa aaattcgaca 2505961 cactccagca gacccagcaa agcatcgagc atatattgaa aaccgtcgat cactctttaa 2506021 cccactatgt gagttcgccg cctctccttc gcacattgtc cgagcctttg cactcagacc 2506081 aatttcaaat ctataaccaa gtgaaccaag agctcaatta tctgcaaagc tttgataccg 2506141 atctgtccaa catgacgtta gtcagttata cgaaaaaatg gtacatgaac aattccggtt 2506201 tgtaccgttt gaatacagac actcttcatg aagcagcctc agcgtacacg aaacaaaaag 2506261 cgagccgctc ctattggacg cttgaggaaa acaatcattt gatttcaacc aaagaaggca 2506321 cagcagaaaa ctgccgctac aatatcaatt taattaagca gcttcctttg aacagcacaa 2506381 atacaaaggg attggccgcc gcaagcatcc cgagctgttc gcttgtcaaa aatatgcccg 2506441 gctattcaaa cgccaacaac ctgtttatca tcgatgaaaa aggcctcatc atccttcata 2506501 acaatatgtc tgacgttggt gaatctcttc ataacgacgg ctttgtccaa aaagtgctgg 2506561 cgcaaacggc caatagcgga cagtttgaaa cagtgattga ccggattcat tataaagtca 2506621 cctatcaaaa atctgactat aatgcatgga cttatttttc tctcgtttcc ctgcctgagt 2506681 taaaaaaaga agccaaatca atcggctgga tcacttttgc agtatgcctc attttgttaa 2506741 cgctttcatt gctgttctct tggcttggct cccgccattt ttacaagccg atcagggtgc 2506801 tttacgaatc attcgcaaga catggagcca tacaagagaa acaacagcct cctcaaaatg 2506861 aatttgagtt aattgaacag agctttaagc agctgaagga cagaaatgac gaccttgaag 2506921 aaacgatgaa gcagcaggcc actcatctgc agcaatattt tatggtcagg cttatgcttg 2506981 gaaaactgac ggatgaggag gttgataacc gttttgaaag cctcggctta aagcaaaatt 2507041 ggcggcacct tgccctgctt gtgctccaaa ttgacacact gaatcatacg ccttatgaga 2507101 aaaaagatat ggatctgctt ttgtttgccg tcaacagcct gattgagcgc aacatcccga 2507161 cggacaaaca tcttgccccc gccgtagttg acaaacagca ggcgacgatt ttgatcaatc 2507221 aaagcgggac aaaggaagaa ttcatggctg agctgaatga gactgcaagg atgattcagg 2507281 aaaaagcgga agctgagctg cagctgtctg tcagcatcgg catcagccag ccgtttgatg 2507341 tgctgacaaa agcgaaaaca gcctatgcgg aaggctcaga agcgttgaaa tatcggctga 2507401 aagcggaaaa caagtcgatc atcttttacg aagaccttga ccagaaaaaa accttcaaaa 2507461 cccattttcc aaagcagctt cagcatgagc tgttcgatgc tgtcaaagca ggagacaagg 2507521 agaaagcgga taaatgcctg cacgcgattt tacaagccat tttcacccag aacaccaacc 2507581 cgtatcaatt tcaaatcgcc atcgcccgtt ttttgaacca tgtgattgag ctgatgcatg 2507641 tgcttgggat cgaattgttt gagcttgaag aaaacaaaat gctgtatgac caaatttttg 2507701 agctgaaaac gttcgaggat accgaaaact ggctaaagaa tgagtttatt gatccgatga 2507761 cagacaaagt gaacgcccgc gcggatgccc agtacaaaaa tatttccgac aacatcattc 2507821 atatcatcca tcatgagttt gaatccgaat tgacactgga cgaaatcgca cgcaggctgc 2507881 attacaaccc aaattattta agcagtattt tcaaaaaaga aatgggaatt tcattcagcg 2507941 agtatgtctc aagctaccga caccatatgg cgaaaagctg gcttgccgaa accgacatgg 2508001 cggtcaagga cattgccgaa aagctgaaat ataaaaactc ccaaaacttc atcagatcat 2508061 ttaagaagct ggaagggatt acaccgggaa actaccgcca gcaaaaaaga agcatgtaaa 2508121 aaacccaaaa ccgcttgcgc gttttgggtt tttccaatgt tattttgctt gtttaaacgc 2508181 ttcttcgtat tcctgaataa tttgttttcc tccgcttgac tcccattttt ccacttcttt 2508241 atcgaactgg ctttctgtga tgtctccaat catatatttg taggtcgcgt catcaatgat 2508301 tttcttcagt tcgtcacccc gttccgactc cgatgcggaa tacaggcttt cagccgggtt 2508361 tgagacgata atcttttcat tgtcctcggt cagctcctcg tacgccgtcc gaagcggatc 2508421 tccagtgttt tttaagtagg ctttatcaat ggcaattaaa gcggacagcg gctgaatatc 2508481 agtctgccag tcttttacct ggctttcttt gcgtgtaaac gttttgtcct cacctttgtt 2508541 gtaatgaacg ccgtcaatgc cataagtcat caggctatag acatcttctt cggcaattcg 2508601 gtcaaaaaac gccaagatcc gtttaagctc agcttccgtt ttcacactcg ttttcgggaa 2508661 agcaaacacg ccgttatggc ctcctgatgc ccatacccgc tctttcccat ctgggccttt 2508721 tatgcggttg atgatctcga gcttcatcga tttatcagag gcatggtcgc gcagattgac 2508781 cgcatctacc atattgccaa tataaattcc ggcttttcct tgagaaaaca gctcttgctg 2508841 ctgggttttg cttgtgacgg gaaaatcctt attcatatac ccgttatcac gcagcttttt 2508901 catatagttc atcgtgtctt tgtattcctg tgtcatgaaa tcaggcgtga atttgccgcc 2508961 cgattccttc caatctgtcg gcatgccttc atacgagcca atcgttttaa acgcgccgta 2509021 aatcaagtca ttacggtctg ccagcccgaa tgtatcatct ttcccatcct tgtccgggtc 2509081 gtcctccgta aatgctttgg ccacttcata aagctcatcc aacgttttcg gggttttcaa 2509141 atttaaattg tccagccagt ccttccgaat gacgatcccc tgtctggaaa gcgggcgctc 2509201 tctgtatatc ccgtagagct tgccgtcaat tgtcacattt ttattaatga gtttgttcat 2509261 tttgtttaag ttgggataat ccttgatata atcgccgatt tcccaaaaca ttcctgaccg 2509321 aaaggcattc atgactgacg aatttttaat atcctggatg gtcacgattt gcggaagatt 2509381 gccggctgca agcgctgcat tcagcctgtc ttctttcacc gcgtctggaa cccaggtgat 2509441 gtcgagttct gtatttgtca gcttttcaat ttctttaatc gccctgtctt tcggcggctg 2509501 ctggtgatac aaaatcgcca tccaagacag ctttaccttt gaatctgggc cagctttgcc 2509561 ttcagccgaa gactgatcag ttcctttaca gcccgccagc actccgccga gtgccagtac 2509621 aagcacaatc aaaagcaccc tccatttgtt tcccatcgta cccctccgtt tcatatttct 2509681 ttatcctttg acagatccca gcaaagctcc ttttgcaaaa tgcttttgta taaacggata 2509741 gacaagcaga acagggatgg tcgccaccac tatgaccgcc attttaatgg tttgctcagg 2509801 cggcgggctg cccgacccca tttcagacat atccccctgc ataccgcttg atacaatgac 2509861 gatttggcgc agaagcacct gaattggcca ttttgctgaa tcatttaagt acaagatcgc 2509921 tgtcatatac gtgttccaat acgtgaccgc ataaaatagt gaaatcgttg cgatcgcagg 2509981 aagagacagc ggcagcacaa ttttaaagaa tatgcccaga tcattgcacc cgtcaatttt 2510041 cgcggactct tccaggcttg acgggatatt ttgaaagaag tttttcagaa tgatcaggtt 2510101 aaaggcatta atggctgtcg gcaaaataag cgcccagtaa gaatcgagca atccaagcga 2510161 tttgaccaca aggaaagtcg gaatcatgcc gccgctaaac agcatcgtaa atacgacgag 2510221 aaacatgagc ggctgccggc cgattaaatc acggcgggat aacccgtaag ccatcagtga 2510281 cgaaagaaac atgctgaccg cagtgcctat cactgtcaca aacacagaaa caagcaaact 2510341 cttataaata atatctgttg aaaaaatgta gcgataagca tctagcgaaa aagtggtcgg 2510401 tattaaaata aattttttcg acacgacttc ttctactgtg gcaaaggatg ctgcgataac 2510461 atgaatgaac ggaagtacgc atattaaagc gaacatcagc aagaaaccat aaatcaacat 2510521 atcaaacaga cggtttttca gtgaatgtgc gatagctccc acctcccttt gtaagcgtta 2510581 tcatattttt ggaaaccgag ctcagcatgt gacgatatcg tgtctaaaat gtagcaaatc 2510641 tgtgattgcc atgtctataa tcatttgaac agtgtccccg gccgggcggg ggctgccgcg 2510701 aattgagacc gataacaaaa gaaaaagagc ataatcttag aaaatgatta tgctccgttc 2510761 tcctcctcgt tcagaagttc agccgtattg atttgtggcg aaaacccaag ttcattcacg 2510821 gcagattcaa tggaccatgg ccggcccgga ttatcagaga cggcgtaata agtgccatac 2510881 cggatgttgg tctcaatggc ggctttgaaa atcgacagca gatcggggtg agaaagcagt 2510941 gtctttttcg tccgttcttt ttcatgcagc gtatccattt catctgtcac gactgttccg 2511001 attcgaaggt tgattactga tagcttattt tccaaataaa acaaatggcc gatctgttca 2511061 gaggtcagct ttaatacacc gtacaagttt tttgacagcg gataatcgct tgttgtgatt 2511121 tcccgtccta agagcgagcg cccgtctttt tcatatacat ctgtgacatg attgctgctg 2511181 gcgaacacga gcttttgaat gccgagctcc gctgccgcac ggcacagata atagcttgcc 2511241 ctatagaaaa catccgtcat tttttcaaac tcagcgatgt ccataatatc gtatttgatt 2511301 ttcacagcga gtaaattcaa gatggcatcg gtatcttttg gaatcttctt caacagctcc 2511361 tcataatttg ccgcgtcagc ctgaatggaa gaggctttgc catcgaaatg atctttatca 2511421 agcacagtca cttcatagtc tgaaataagc ccttcagcaa gcagtctccc aatcacacca 2511481 tttccgccgg cgatcagcac ttttttcacg atgttcactc ccctttttta tagattgccc 2511541 attttcggcg gggctgacac ttttttggca ctcacattct taggcttatt caaaagtcac 2511601 cggcagctcc tcaagcgccc gaaatccaaa aagcggccga taccgccatt caaaatccgc 2511661 aagattaagg ctgggcattc gctgcagaag agtgttaatc gcaatttgcg cttctaatcg 2511721 tgccagcgag gaccctaagc aaacatgatg gccatgcccg aatgaaagat gcggattagg 2511781 acttctcgta atatcgaaga catcggggtt cgtgaatatg ctagggtctc gattagccgc 2511841 tcctaacaaa agatagactt gttctccttg acggatcgtc accccgcaga tgtcaatatc 2511901 ctctgacgca actctggctg tcatttgcgt ggggctttca tagcgtaaac attcctcgac 2511961 tgcggtacca ataagatctg gattttctct cagtttcaaa agctgttctg gatgctgcag 2512021 cagacaaagg actgaattgc tgatgagatt gaccgttgtc tcatgtccgg cgatcgccag 2512081 caatatgcac gtagatgccg cctcctcttc cgtcagctta tccttttctc tccccttcaa 2512141 gagcatgctg atcatatcct gttgagggtg gcgttttctc ttttgaatca gctctttgaa 2512201 atatgccata gcctgcacag ccataatatt gccctctgtt aatgcctttc ttgagcgggt 2512261 aaaatcaatc gtttgaatga gactcgcagc ccactccttt aattgctccc tatcttcctc 2512321 cggtacacct ataatgttag ctatgacaaa acttgctaaa ggaaaagcaa agtccgaaat 2512381 gacctccatc ttttttttac cttgcacttg atcaagcaaa tgatggacag tttcaatgat 2512441 atacggctga taactctctg tcgttctcgg cgtaaacgct ccgctggcaa gcgtccgcaa 2512501 tcgtctatga tcaggctggt tctgaaacag catcatttga ttttgcacat gtgaaaggtc 2512561 ctgatatttg gttgagctct caggcagcgg ggtgcggact ttgaatctcg catctttcaa 2512621 aatagcagcc gtttcttcat atcctgtgac ataccagccc gggtatttta agaaactccc 2512681 tttatagata ggatgaacag ctcgcaatgt gtcgtaaaaa gaatatgggt ttttcaaaaa 2512741 ctcagaagat gcagttgacg atgcaattgt cacgtgattt tctcctttct gttcaaaaat 2512801 aaaaacaatc gacatcatac cgattgcttt tattgattct ttcagctttt cgcacttaaa 2512861 ctagccttca tttcttcgac tgattcaact tcaaagccta aatcactcag cattttatga 2512921 tcctccgtct cctcttgccc ggcagttgtt aagtagtctc cgacaaaaat ggagtttgcg 2512981 gcgtaaagcc ctaatggctg caatgtgcgg agattgacct ctcttcctcc ggaaatgcga 2513041 atttcttttg atggattgat aaaacggaac agcgccagca cttttaaaca atacagcggg 2513101 tttaattcgt tgacgccttc taacggcgtg ccatcaattg catgcaaaaa attcacagga 2513161 atggaatccg cgtcaagagc cttcaagctt ttggcgatgt caatgacatc ctgtttcgtc 2513221 tccttcatcc cgataatggc gcctgaacac ggagacagcc ccgattcttt tgcgatttca 2513281 accgtattga ctctgtcatc gtatgtatgt gaggttgtga tgtttgaatg gtttctctgt 2513341 gacgtattca aattatgatt atagcggtct actcctgcat ctttgagccg cttcgcctgc 2513401 tctggcttca acagtccaag acatgcacaa atcttcagtc catacgtctc tttaatttcc 2513461 tgaaccgcat ctacgacctg atccacttct ctgttagacg gacctctgcc gcttgccacg 2513521 atacaatatg tgccgatatt cagatcgtgc gcccgcttcg cgccttcaag cagcgtttcc 2513581 ttattcacca tccggtaaga ctcaatcggc gctttcgaaa tcgcagactg tgaacaatag 2513641 ccgcagtttt ccgggcagag cccggatttc gcattcataa tcatattgag ctttactttt 2513701 tttccgtaaa agtgttttct gatgtgaaaa gccccgtgca ttaatagcaa aatatcttca 2513761 tcaggacaat gtaatattga aagcgcctct tcgtcagtca cttctgctcc agccagcacc 2513821 cggtctgcga gttccatcca ttgattcatt ctcatacccc cacttgattc atcagtaatg 2513881 atagattgat atggtctttt accatatgta gaaccgtttc tttcgtcacg ttggcaagct 2513941 ttggcgtaac ccctaaaatc ggcacaccgc ataagcgctc aatcatctca ggattggttt 2514001 tttcatcttc atcaggagag tcactgattc cattgatgat aattccggcg attggaagcc 2514061 ccatgctttc tgcatatttg acagttaaaa aggtatgatt aatggttcca aggcgaggac 2514121 gcgccacaat aatcatggga agctgcaacg cttttatgac atgactgacc aaatagtcct 2514181 ctcccaatgg cacagaaata ccgcctgcac cttctacgat gaagcattca tgtttttctc 2514241 taatccgccc ccaatggctt aaaacctctt ccatggtgac agtctttccc tcaagtttcc 2514301 ctgcaacgta tggtgcaagc ggcgccttga aggcaaaagg cgtaatgtct tcatgagaaa 2514361 gactggtctg cgacatatct ttcagcaaac ttgtatcact atctggatga tggcgcgata 2514421 tcccgcttaa aaatggttta tacaccccga catgtctatt attgtctttc aataaggcag 2514481 caagaccgct ggatataacc gttttcccta cttctgtatc agttcccgtc acaaaaaaac 2514541 ccctcaaatg atgtgcagct cctttccgat tgaatgaaat gtttgcagca aatgatcaat 2514601 atcacccata ctgtggtcag acgtgattgt aattcgaatc cggctttcac ccggcgcaac 2514661 ggttggcggc cgaatggcag gagcataaat tcccttgccc tgcagttttt cagcaaatag 2514721 gaccgtttta tgggcatcgc caatgactac aggaataatc ggtgtgtgat ctcctttcac 2514781 cacataaccc atattcttca gactggttct gatcatgctg atataagaaa ataaaagctg 2514841 tcgtttttcc ctgctggctt caatgatgtt gaaagcctcg tgagcagccg cacagctggc 2514901 tggcggaata gcggtttgaa agataaatgt tctggcatgg ttcagcaaaa agtcgatgaa 2514961 gaccgctgat cctgccgcaa aacctccttc cgcgccaaca gctttgctta aggtgccgat 2515021 aacaatgtcg ggacaaacac caaagtattc actcgttcct tgtcccgaat cgcccaaaac 2515081 tcctgttgcg tgggcatcat caacgaccac gaaggcatga tagcgtttcg caagtgagat 2515141 gatctgatca agaggggcga ttgtgccatc catgctgaat actccgtctg ttacgataaa 2515201 acggcgctga taacgctgtg tttcattcag cttgttttca agatcattca tatcaatatg 2515261 ccgataaaca actgtatcag ccttagaaag tcggcagccg tcgatcatac ttgcatgatt 2515321 gagctggtca cttaaaatga catcttcctt ttctggcaag gatgaaagga caccgacatt 2515381 ggccaagtaa ccgctcgaaa acagcagggc cgcttctgtc agtttaaagc tggcaatctt 2515441 cttttctagc ttttcatgcc agaccgaatt gcctgtcgtt aaacgtgaac cgctgcttcc 2515501 tgtcccaaat tgctgcaatg ctgtttgggc tgcatcgatc aaacgtctat cgcttgcgag 2515561 ccctaaataa ttgtttgagg accagaccgt ttgattttcg ccatcaatat tcctctctgg 2515621 aaccggcgct ccatccattg accgcaggtt acgatgtacg ccggcttctt tcattctgtc 2515681 taaccgctcg tttaaccagg aatcaatctt caaggctcgt aacctcgtgg atcgcttgtt 2515741 tcataatggc aaccatttcc gagagctctt cagctgtgct ggcaagagga ggaagaaatg 2515801 caatcacgtc cccaagcggt cttgtcagca ttcctaactc tctcattttt aaggaaactt 2515861 tgtatccaat ccgccgatca gccgggtaag gttctttagt ttcctttgat cgtacaagct 2515921 ctgcaccgca cataaagcca agctgccgaa tatccccaac atgaggaaga gcgtgcagat 2515981 cttgaagaag aaaatggagc tttttacttt tttccgctac ttgttccaca atgttttcag 2516041 attcaaataa tgccagattt tcaagcgcaa ccgcacagcc aagctgattg cctgtatagg 2516101 aatggccatg gaaaaaggtt tttaggtttt cataatcatc atagaatgcc ttatagatgt 2516161 cttcagtggc aaacgtaacg gcaattggca aatagcctcc tgtaatgcct ttaccggcag 2516221 ccatcagatc aggctggaca ttctcgtgct cgcacgcaaa catttttcct gtacggccaa 2516281 agcctgtagc gacttcatca acgatcatta agacatcgta tgttgtacat agctcgcgca 2516341 cgcctgccaa atatccttcc ggcatcacga tcataccgga cgcgccttgt accattgatt 2516401 caatggaaag cgcggcaatt tcctcatgat gttcctcaag cagctgtgca agctctcgga 2516461 ggcactgatc acggcactca tcaggatcac cgctttcaga acgatacaca taaggaatcg 2516521 gggccttgta actctcgaac atcaacgggc cgtatacgtg gtgaaaaagc tcaattgaac 2516581 cgacactgac ggcgccaatc gtatcaccgt gatacccgtt tttcattgcg atgaattttt 2516641 gtttctcggg cttcccgatg ttcttccaat actgaaacgc catttttagg gctatttcca 2516701 tcgcctctgc gccgctgtct gaataaaaga cccgcgtgag cttttttggg ctgatgtcga 2516761 ttaatgtttc ggcaagctgg gttgctggaa cattggtcat gcccaataac gtggagtgcg 2516821 caatttttcc gagctgtttt tttatggcgt catctagttc ttttttgcgg tgtccgtgga 2516881 cattaagcca aaccgatgaa aaaccgtcat agtattcctt gccgtttatg tctttgactt 2516941 tgattccagt cccgctttcg atgattaagg ggttttcatc ataatctttc atttgggtaa 2517001 atggcagcca gaggtgcttt ttactttttt ctatcaaatc atgagtcatg atcttcctcc 2517061 cactctatta aaataggctg cttctccagg tcatgtatgt acgtgtttac atcattggat 2517121 ccatcaataa aaaagactcg gcagccctct tcagtcccgt attctttcat tgctgtaata 2517181 cgctgatagc ccattttctt acccgcaaca tagcctgtta tgtaatccgg atcgtccgac 2517241 cagcataatt ctgcaacgac tgccgggtgc cggcttacct ttgaagcgag cgcaagggcc 2517301 tcttttattc ttgaatgagc tggcacgtga ctgtgaagcg cccatttttc aaaattagcg 2517361 tccggccaat ccattctgga gacccgcacc cctttttctt ttgtttgatc cattcgcttg 2517421 cctgtatgaa tatcaaacaa caccgcaccc ctgacatctg accattcagg gatttgttca 2517481 tatgcttttt caatcacgtc tcgtgaaacg ccttcttttt ccaataacaa tcgggcaagc 2517541 ttttgtcctt cttccgggca gctcacttca ttcgtatgca caggcaatgg ctgaatggtt 2517601 tttatcgatt catgtacctc ttcaaattga atttgcataa aatcaggttt tcctcttgaa 2517661 tgggataacc ctttttctaa taaagcattg actgtatgct tcatctcatg gaaaggaata 2517721 agccgttctc cgccggatat atgctttccg ccgtcttcat gagatccatt cattgaagcc 2517781 ctcattctga cactataaaa agtttcttct tgcatcattt ctcgcccttt cactgataac 2517841 tgaagaacgt gtagcgcttc tcacctaaat tgttaaccaa ttatattcaa aggttaacaa 2517901 ttagaatata ttattctctc ctgtttctgt caatagaaga aaggatcgat ttatggcagt 2517961 tggttaaaag gaaacaaaaa gaccgttttc acacaaaacg gtctttttcg atttcttttt 2518021 acagtcacag ccacttttgc aaaaaccgga cagcttcatg ccttataact gctgtttcga 2518081 aatgtcccga agcagaacgg accactcggt agcaatcagc agctccctgt ccagcataga 2518141 cagctgtcaa ttctttttcg attttgtcca cgccctcagc cggcgttaac cgatcgtgta 2518201 caccaacaag actaaggtgc gggcgcggcg cgatcaggct ttggatctcc gatgcggaaa 2518261 aatgctttgc aagcgatggg acgtaataat aaaagccgtg cctgtcaaga ttctgtgttt 2518321 tgatcagcac gtgatgatcc acctggctgc acaaatccac acacacctta atccggtcat 2518381 cgagcgccgc tgtccaccac gccatcaaac ctcccataga catgccgatg gttccgatcc 2518441 tgtcaggctg aacatcagag cgtgactgca tatagtctaa cgcacttaaa ctgtcataaa 2518501 tcatcatccc ccacatcact tttccggtga gaagcatttc tttaaatatc tcgctttccg 2518561 cttttccccg ccgatctcca aacccccaat gatcaatcgc aagaacgccg tatccgagtg 2518621 aagtaagctc atcagaaaaa gaaggcgttt tcaaataatc cgctccctca atcagctcac 2518681 tttttcccct atcatactgg cctccatgcg aatgctgaaa caatacggct gggcacggtc 2518741 cttctgtttt cttcggcttc acaaaataag cgggcgcctt ttcatgtcca tttaaatcga 2518801 gcaggagcgt ttcaacgata ttttcttctc tttcttcaat acgtaatgtc tcaacactga 2518861 ttggcctccg atcaggcaaa tcaccaagca atcgaaacag ttgctttctt ctttcggctc 2518921 tcatcccatc acccttcctt attcgcttac ttcacattta cgagacagat ctgggttccc 2518981 ctttattttt ccaacataaa tcacatcatt tactaaatat ttagtaaata ttatggaata 2519041 tttcgaaaac aattattgta accgcttact tttatatgat aatatcaatt tatcaaaaac 2519101 agatgagtta atattttact aaatagatga gagggatacc catggttcgt attaaagata 2519161 tcgccttgaa agctaaagtt tccagcgcaa ctgtgtccag aattttaaat gaagatgagt 2519221 cgctttctgt tgcgggcgaa acgagacaaa gagtcatcaa catcgctgaa gagcttggtt 2519281 atcaaaccgt tgccaaacgc cgaaaatccc gcgggcaaaa acagcgggct cagccgctga 2519341 tcggtgtgct gagctgtctg tcccctgatc aggaaaggca ggacccttat ttttcttcca 2519401 ttcggaaagg gattgaaaag gaatgctttg aacaggaaat tttcattaca aattcgattc 2519461 atctcggctc ctttcaggaa catatctttc gggaattgga tggtgtcatt gtcatcggcc 2519521 gtgttcatga tgaagcggtt aagcatatca gcgggaggct ggagcatgcc gtatttatca 2519581 atcattcacc agatccgcaa gcatacgatt cgattggcat cgattttgaa tcggcttcac 2519641 gccaggcgat tgatcacctt ttcgacttag gctacaaacg gttaggctac attggcggac 2519701 aagaaaaaga gcatacgctg aaggacggcc aaagcattcg cagaacgatt gaagataaac 2519761 gcctgaccgc ttttttggag tcagccgccc cccagcctga gcatgtgctg atcggagaat 2519821 acagcatgcg tgagggctat cgcctgatga agaaagcaat cgatcaaggc catctgccgg 2519881 aagcattctt tattgccagc gattctatgg cgatcggcgc attaaaagcg ctgcaggaag 2519941 ccggactgca agtgccgcgg gataccgcaa tcgtcagctt taacggcatt gaggaagctg 2520001 aatttgccag cacgccttta acgacggtga aggtatacac agaggaaatg ggccggacag 2520061 gcgtaaaact gctgcttgac cgtctcaatg gccgaacgct tcctcaacat gtcaccctgc 2520121 ctacaacatt aatcgtaaga caaagctgcg gatgtacagc aaaggaggtg acataagcaa 2520181 agattcatca cgatgataag gaggaaaaga tgaaacacac ttttgtttta tttctctctc 2520241 ttattctgct tgttctgccc gggtgttcag cagagaaaag ctcagcagat accgcaaaaa 2520301 agacgttaac catttattct acaatgtcaa ccgacagtga aagagatacg ttcagaaaac 2520361 tagcggcagc attcgaaaag gaacacagtg acattcatgt cagccttcat ttcccaggca 2520421 atgactatga aaatatgatg cgtgtcagaa tggcggccaa tgatttgcca gatctattcg 2520481 atacacatgg ctgggggaaa atcaggtacg gagaatatac agcggatctc cgggatatga 2520541 aatggactca agatcttgat cccaatttaa acagcatcct caaaaataaa agcggaaagg 2520601 tgtatgccta tccaatcaat caggcaaaag acggtctggc gtataatcgc aatattttag 2520661 accgttacgg cattgctccg ccggaaacca tggatgactt tatcaaagca ctgagaacga 2520721 ttaaagaaaa gagcaaggga agcattgttc ccttctggtt tgccggatat gacaaaagct 2520781 cattcgccca atattacgac caattcgcta cacctcttct catcacagac cctgcccata 2520841 atgaaaaaaa acagctcatc aacggcactt ttcaatggag taaattcact tatttatcag 2520901 aaatcctcaa acaaatgcag aaagaaaaat tgatcaatat cgacgccgtc acggcaaaaa 2520961 aatcacagct cattgaatta atggcccaaa acaaaatcgc ctttacaatg caaggcggca 2521021 cactcggcca agacgttgcc cagatcaacc cgaacgtcaa ggtcggcatt atcccgacac 2521081 ctgccatcca tcccggtgat gacccgatat ggatcggcgg tgaacgctac acccttgcag 2521141 catggaaaga ttcgcctcaa ttaaaagagg caaaagattt tatcgcattt atggcccgcc 2521201 cggccaatgc caaacaaatg gctgaagcca catcgcttcc ttcagggctg accaatgtga 2521261 aagctgatat tttctacgca aacgattatg agtattatca agatgtcaaa gtcgagcctt 2521321 acttcgaccg gttatacttg ccaaacggaa tgtgggatgt cctgggcacg gttgggcagg 2521381 agctcgcggc tgacattttg gcgcctcaag acatttcgca gaagctggga agagaatata 2521441 aacgactccg ggagcaatcc gaaacacagg gagctgaaaa caatgagtga gatcgcaagg 2521501 gacgttcatg tgaaacaggt taagccaaaa aagcagtcct cactttggtg gatgtacatt 2521561 cctgctttgc tctccgttct ggtctttatg atttacccgt ttgtgaaagg cacattgatt 2521621 acctttacaa actggaacgg attttcacaa gtctaccaat gggttggatt cgcgcaatat 2521681 gaaaggctgt tttctgatcc tgatacttgg catatcttaa aaaacacgct gcattacggg 2521741 cttggcagca ccttttttca aaatgtggtc gggcttctgt acgctctcct cttaaatcaa 2521801 agcattaaaa cgaaagcggt aacaagaaca attgtgtatt tgccggtgat gatcagcccg 2521861 ctcattatgg gctacatttg gtactttttc ttctcctatg acggaggcgc gctcaacgat 2521921 ttgctcgggg tcttcggcat cagccctatt aatgcgctcg ccagtccctc gctcaatcca 2521981 tggatcattg tcatgattaa cacctatcaa tatgtcggga tcgctatggt tgtctactta 2522041 gccggtctgc aaagcattcc gaaagactac tatgaagcgg cgcaaatgga tggcgcgaaa 2522101 caaggccagc agttttttac catcacgctg ccgctgttaa tgccctccat taccattaat 2522161 atagtcatca acattatcgg aggcttaaag ctgtttgacg tcatcattgc actcaccgca 2522221 ggcggccccg gaaatgcgtc acaatccatg tccacgttta tgtatgattt gtatttcaaa 2522281 cggcaggatg ccggctatgc cgcaacgcaa ggcatattta tggcatttgt cattttgatc 2522341 atcagctttt gcgcgcttgc gtactttaaa agaaaggaga cggaaatgtc atgagagccg 2522401 cccgtacaaa aagcatgcgg atcattacgc ttcttgcagc cattgtggcc tgtgcgcatt 2522461 ttattccttt ttatatcctg ctgaccactt cattgaaagc aaaaggagac tacagttcga 2522521 aatggatatt tccagccgac atctcctttc ataatttttc agaggcgtgg gagcgcgctt 2522581 cgctaggaaa ctcttttata aacaccatga tcatcacagg tttttctgcc ttgttattaa 2522641 ttatattcgg ctcacttgcc gcctacccgc ttgcccggcg ggaaacgaaa ctgaataaag 2522701 ccgtttttgc cttgctgatt tccattatga tcatccctcc gttaacgtcc atggttcctt 2522761 tgtaccgaat ggtcgtggac gccggaatgg tcaatacaca cgcaatcgcc attttcatca 2522821 atacagcggc ttacatgccg ttaaccgtat tcttatattc aggctttatc cgatcgacca 2522881 ttccaaaaga gcttgtagaa gccgcaagaa ttgacggtgc aggcatgctg aaaatctttt 2522941 ttacgattgt gtttcctctg ctgaagccga tcactgcgac catctgtatc atttcttgtg 2523001 tctttatttg gaacgactat caatttgcca ttttcttttt acaagatcaa aaggttcaga 2523061 cattaacagt agccatggca ggttttttcg gagaaaacgc aaacaacctt catttagttg 2523121 ccgcagcggc acttatggca atgctgccga tggttgttct gtttttggcg ctgcaaaaat 2523181 actttattgc cggcctgtct tccggagcgg taaagggtta acattaaagg gggaagcaat 2523241 atgaaaaaga ttacatttat cggtgcaggg agcacgattt tcgccaaaaa tgttttggga 2523301 gactgcctgt taacagaggc actgaatgga tttgagttcg ctctttacga cattgatccc 2523361 aaacgcctgc aggaatccca gctcatgctc gaaaatctaa gagaccgtta taacccaagt 2523421 gtggccatca acagctatga tgacagaaaa ctcgccttgc aaaacgcagg ctatgtcatc 2523481 aatgcgattc aggttggagg atacaaaccg agcacagtca tcgatttcga gattcctaaa 2523541 cggtatgggc tgcgccagac gatcgccgat acagtaggca tcggcgggat attcagatct 2523601 ctcagaacaa tcccggtctt atttgatatc gcaaaagata tggaggaaat gtgccctgac 2523661 gcatggttct taaactatac aaatccaatg gccactctta caggcgccat gctccgctat 2523721 accaatatca aaacaatcgg gctctgccac agtgttcaag tgtgcacgaa ggatttattt 2523781 aaagctctcg gaatggagca tgacggaatt gaggaacgca ttgcgggcat taatcatatg 2523841 gcttggcttt tggaagtcaa aaaagacggc acagatttat atccagaaat caaaaggaga 2523901 gcgaaagaaa aacaaaaaac aaagcatcat gatatggtgc ggtttgaatt aatggataag 2523961 ttcggctatt atgtcacgga atcgtccgaa cataacgcag agtatcaccc gtactttatt 2524021 aaacggaatt accctgaact gatcagcgag ctgcaaatcc cgctcgacga atatccgaga 2524081 aggtgcgtca agcagattga aaattgggag aaaatgcggg atgatatcgt caataataaa 2524141 aaccttacgc acgaacgctc aaaggaatat ggttcaagaa ttatagaagc aatggaaaca 2524201 aacgaaccat tcaccttcgg aggaaacgtc ttgaatacag ggctgatcac caaccttcct 2524261 tcaaaagcgg ttgtggaagt gacatgcgtc gccgacagaa aaaaaattac accgtgcttc 2524321 gccggagaac tgcctgagca gcttgcagcc ttaaaccgga cgaatattaa tacacagctg 2524381 atgacaatcg aagcggctgt cacacgaaaa aaagaagcgg tttaccaagc tgcaatgctt 2524441 gatccgcata caagcgcgga gctttccatg aaggacatca tctccatgtg cgacgattta 2524501 tttgcagcac acggcgattg gcttccggaa tacaaataaa aactagggga ccgctctccc 2524561 ctagtttttt ggttttgttt cgccttccca ggccatcatg ccgccttcaa cattgactgt 2524621 tttaaagcct tgctcatcca ggtacttgca gacgttcatg ctgcgcattc ctgagcggca 2524681 gataaatacg tactctttgt ctttatcaag ggtttccatt ttttcaggaa tatcccccat 2524741 gcgaatatga acggcttgcg ggatcatgcc ttccgctacc tcttcatctt ctctgacatc 2524801 aattaaatat aattcttcgt ccgcctcaat tttttctttc aaagcggctg tgctgatttc 2524861 ttttatttcc aaagaaaaca ctcctattca cagtgatcat gttcagtata tcaaagtcag 2524921 ccgaacgatt gctattctga gactgatgaa aaaaaatccc cttttggcaa aggggatttt 2524981 ttctaggctt agtttgccac aatattgaca agcttcccag gcaccgcgat gattttccga 2525041 atcgttttgc cttcaagctg ctctttgacc ttttcatctg cttgagcaag ctgttccagc 2525101 tgttctttcg ttgcatcggc aggaacctgt aatttcgctt ttacttttcc gttcagctga 2525161 acaacgattt caacttcatc atccacaagt tttgtttcat catatacagg ccaagcttcg 2525221 taggcaattg tgccggaatg gccaagcttc tcccatagct cttccgctaa gtgtggcgcg 2525281 acaggagaaa gaagcttcac gaagccttcc atatattctt tcggcagttc tgttgcttta 2525341 taagcttcat taataaagac catcagctgg gaaatacccg tgttgaaacg aaggccttca 2525401 taatggtctg tgactttcat gaccgtttca tgatagacgc gctccaatgt ttcacccgcg 2525461 ccttcaacga tttttccatt aagctcaccg ctgtcttcaa taaataggcg ccatacacgg 2525521 tcaaggaaac ggcgcgcacc gtctaatcct gattcagacc aggcgattga agcatcaaga 2525581 ggtcccatga acatttcgta caatctcagc gtatcagcac cgtgagaggc cacgatttcg 2525641 tcaggattga caacgttccc tttagattta ctcatttttt cgttgttttc gccgagaatc 2525701 attccttggt tgtacagctt ttggaacggt tctttcgtcg gcactacgcc gatatcataa 2525761 aggaacttat gccagaagcg ggcatacaga aggtgaagca cggcatgttc tgcaccgccg 2525821 atatacatat cgaccggaag ccatttttcc aatttttctg gtgatgccag ctgatccgga 2525881 ttgtgcggat caatatagcg caagaaatac cagcagcttc ccgcccattg cggcattgta 2525941 ttcgtttctc ttcttccttt tttccctgtc tcagggtctg tgacttccac ccactcttta 2526001 atgttcgcaa gcggtgattc gcccgttccg ctcggtttga tttcatccgt ttttggcaaa 2526061 atcagcggca gctcctcttc cgggacagct gttgacgttc cgtcttccca atgaatgacc 2526121 ggaatcggct cgccccaata acgctggcgg ctgaagagcc agtcacgaag acggtacgtc 2526181 actttcttct caccgttttt cgtttcttcc agccaagcga tcactttttc aatcgcttcc 2526241 tgtttgtgaa ggccgttcag gaaatcagag ttcacgtgct cgccgtcgcc agtataggct 2526301 gcttcctcaa cgttcccgcc ttttacgact tccttcaccg gaaggccgaa tgttttggcg 2526361 aattcaaaat cacgctcatc gtgtcctgga actgccatga cagcacctgt tccgtatgat 2526421 gcaagaacat aatccgcaat ccaaatcggc agtttttctc cgtttacagg attgatcgca 2526481 tacgctcctg taaatacgcc tgtctttgtt ttcgcaagat ctgtgcgttc taggtcactc 2526541 tttgattgaa tttctttgat ataagcttca acagcttctt tttgctctgc cgttgtgatg 2526601 ttttccacca atgcgtgttc cggggcaagg acagtgtatg tagcgccaaa cagcgtatct 2526661 ggtcttgttg taaacactgt aaaggaatca tcatgtccat ctatagcaaa atgaacgtga 2526721 gcgccttccg aacggccgat ccagttgcgc tgcatatctt taatgctttc cggccaatca 2526781 agctcttcca agtcctcaag gagcctgtcc gcataagcgg tgattttcag catccactgc 2526841 ttcattgggc gtctctctac cggatggccg ccgcgttcgc tcttgccgtc aatgacttct 2526901 tcgttggcaa gaacagtacc gagcgcaggg caccagttta caggcacttc gtcaacgtaa 2526961 gcaaggcctt tttcgtatag ctttaagaaa atccattgcg tccatttata gtattcaggg 2527021 tcagtcgtat tgatttcgcg atcccagtca tatgagaagc caagcgcttg aatttggcgg 2527081 cggaagttat caatattctg cttcgtaaac acagcggggt cgttccctgt gtcaagcgcg 2527141 tactgttcag ctggcaggcc gaatgcgtcc cagcccattg gatgaaggac atcatagccc 2527201 tgcatgcgct tcatgcggga cagaatatcc gtagctgtgt atccttcagg atggccgacg 2527261 tgcaacccag ctccagacgg ataaggaaac atgtccagcg cgtaaaattt ttgtttttca 2527321 ttattatcaa gagtggcaaa tgttttgttt tcaagccaat atgtctgcca tttcttttct 2527381 atctctttgt gctgaaaact caaagtaaaa acctccttct gattgaatac ggcgtgtatg 2527441 gttcaagtat tgacgggaag gagaggatta tattcagaat attcccaaac taaaaaaaac 2527501 tccctcatcc caaaaaggga cgagagactt tcgttttccc gcggtaccac cctcgttagc 2527561 gcggcatacg ccgcactcac ttgatacttt taacgcagtt atgcgtcagc ggcttttcac 2527621 cgctgcaact ctgaggtgag ttcggaaaca aacttgattg actttcacca gccgtcaact 2527681 ctctgcaaca atatctgttt cttactgctc ctcttcattg ttcttatcgc aaccgtaatc 2527741 taactgtatt ttatagaatt ctgttcataa gtgcaagcag gtttgtatac aatgggaatg 2527801 taccctgaac gggcggagat tgaggacaat tattcgggtg gagttttggt ttgacgtttg 2527861 gactcggccg gttcgccgcc gctgttcagt tctctcacaa agtcaaaact tctgagaaca 2527921 gcttcaccgc cgtagcctga gataatggat aagatgacaa gttgaattcc tgaatcgggg 2527981 tcagcggata atacaagtaa aatggaagcc gtcatgccga taaaccaatc ttccaaaaat 2528041 ccaaggtaga taaaccgctt cgtcattctg ggcttctcca gcctgcctct ctttttcaca 2528101 tgaccgagaa tccccatgat tcctccaatt acacaagcaa tgagtacctg atgcagcatc 2528161 ttcatcatca ccttcctaaa gcccttattt cgtaaagcga cttcaggcca tccagccccc 2528221 ttaaacgatt ccgatgattt tcgatatcta cataccggca aatctgtaaa aagcttgttt 2528281 cttccattat atgtgaacac atgatcggta agcttgatgc attggattca tttttcaccc 2528341 agtgacattg acctagtcac ctatttagca tgtagaaaac ctttccgttc atatgttcaa 2528401 attctgttct tatttttagt gtatacgagg acaagcccta atgacaaaca acaaactgca 2528461 cttgcttgaa tcagaacatg tgttgtgcta cggttactgt agaattcatt tttaaaaagg 2528521 ggaatatcag gctttcgcat agcaagctga cggcctaagg gggatttata tggctagttt 2528581 tcaatcattt gggataccag gacagctgga agtcatcaaa aaagcacttg atcacgtgcg 2528641 agtcggtgtg gtaattacag atcccgcact tgaagataat cctattgtct acgtaaatca 2528701 aggctttgtt caaatgaccg gctacgagac cgaggaaatt ttaggaaaga actgtcgctt 2528761 cttacagggg aaacacacag atcctgcaga agtggacaac atcagaaccg ctttacaaaa 2528821 taaagaaccg gtcaccgttc agatccaaaa ctacaaaaaa gacggaacga tgttctggaa 2528881 tgaattaaat attgatccaa tggaaataga ggataaaacg tattttgtcg gaattcagaa 2528941 tgatatcacc aagcaaaaag aatatgaaaa gcttctcgag gattccctca cggaaattac 2529001 tgcactttca actcctattg tcccgattcg caatggcatt tcggctcttc cgctagtcgg 2529061 aaacctgaca gaggagcgat ttaattccat cgtttgcaca ttgacgaata tcttatcaac 2529121 atccaaagat gattatttga tcattgattt atccggattg gcccaagtga acgaacaaac 2529181 ggccgaccaa attttcaagc tgagccattt gctgaaattg accggaactg agttaatcat 2529241 tactggcatt aagcctgaat tggctatgaa aatgaataaa ctggatgcca atttttcgtc 2529301 gctgaaaaca tattcaaatg taaaggatgc cgttaaagtg cttccgatta tgtaaaaaga 2529361 tcccgctcac ccagctggat ctttcagatt gttgacaaaa tcctaaaatg gttttcattt 2529421 taggattttg tcatcttttc agcgtgattg aaaacccttg aagtctagga aggacgagca 2529481 taggagcgga gcgaatgttc taattcgtga gcaccgaagc gcaggcctga caacgaatgc 2529541 gagggtttgt cgacacgctg aaagatcccg ctcattcggc gggatctttt attatgaaga 2529601 gattgatgcc tgcttatttg tttctttagc tgattttatc cgtttgtcat atagaagcgt 2529661 tgtggcaata ctgatcagca gcaataccaa cagagataaa acaagagccc taatgccgta 2529721 atgatcgaca agcactcctc cgaacagggg accaatcatt ctgccgcctg tcgccgcact 2529781 gttgacaaag ccttgataaa agccttcttt ccctttaggg gcaagctgat tggcaatagt 2529841 cggcacagca ggccaaacaa gcatttctcc gatagtcagg atcaccatcg cagcgagaaa 2529901 catcggaaat tgctttgcag tcagcagcat gctgaaagac acaataaaaa tgataaagcc 2529961 gatgaccatt tgcgctttta gcgactcggc ccattttttc accacaaaac tgacgagcgg 2530021 ctggccgagc acaatgagaa ttccgttaac cgtccacagc acgctgtata aggaaagaga 2530081 tattccaatg ctttgtgtgt acgaagcaat tgtggttgac cactgagaat aagccagcca 2530141 tccgagtaca tagcctccgc ttaaaatgat cagtgcggca aattttgctt tgctgttcac 2530201 agcatcataa tcaagcacgg atgtttggga tgcatcgccc gtttgaatat ttcgaaatcc 2530261 gaaatataca ataaagaaaa agatcagata caatacggca tttgccaaaa atacatatga 2530321 aaacgagaaa gatgccacga caccgccaag cgctgaacca acggccacgc ccgcgttttg 2530381 cgcgacatat atcgcattaa atgccttcct tcccccttca ggccataccg atcccgccat 2530441 tgcgtagctt gccggaaaaa caacaccgga gccaaagccc acaatcgtca gcagcacaat 2530501 ataggctggc caatcatgaa aaaagacaag acccatcagg cttgctaacg taatggctat 2530561 cccaagcata atcgatttaa aaccgccgat tttatcaaac aaaaaacctc cgcataaatt 2530621 gccagccaca ctggcgccgg aattcagcat caggacaagt ccggctactg ttaacgactt 2530681 tcctaaatga ttatggatat aaatcgtatt cagcggccat aaaaaagaag cacccgtcac 2530741 attgataaac attccaatga ctaaaatttt aagagcacgc ggcatactca tccccctttc 2530801 ttacctaaaa aagctcatga aaaaaacgaa acctaaaacg gctccgtacg aatccagtta 2530861 tcatagcaca ttcattctat ctgtctctct cacatttttc aactgatgag cgtgaaaaaa 2530921 tctaacaaat attgtttgaa aaatgtaaaa taaatagaaa aaggggtcat attatggaaa 2530981 tggtattagc attcttaggt tttctggcat gtctcattgc actgggctat ggattatatc 2531041 accttgtcag atatgtactg aaaaaggaaa aacgtttctc aaagagactt ttttggccgc 2531101 ttttcattgg aggccttgtg ctgctcttta ccggggcagc attggcagaa cctgacactg 2531161 ccgcagcaaa tgccgagaaa aaatattcag cgctaaacgc cgaatataaa aacctcacaa 2531221 aagagcacga agaacttgag aaagaatata aatctgtcag ctctgaagca aagaaattaa 2531281 aagacaacaa agaagatcaa gacaagcttg agaagcttaa aaacgaaaat agcgatctaa 2531341 aaaagactca gaaatcatta aaagctgaga ttaaagagct tcaagaaaat caaaagcagc 2531401 tcaaagaaga tgcaaaaacg gcaaaggctg aaaatgaaac acttcgacaa gataaaacaa 2531461 agcttgaaaa tcaattaaaa gagacggaaa gccaaaccgc cagctctcat gaagacactg 2531521 gaagttcttc aaacaatacg agtaaaagtg atgaaaccaa aacagctgac aaagcagaag 2531581 gctgtaatat caaaggaagc agaaacggca tctaccacac gccaggcagt acatactacg 2531641 accggacaac cgatccggct gaaatgtttt gctcagttga agaagctgaa gccgccggtt 2531701 atcgggcgcc aaaacgataa acaaaaagct ccagaatgtc tggagctttt tctgtttcac 2531761 aacgacgatt taatgacctt cttataataa agaactgaca gaaaaccaaa aatggagtag 2531821 agcgcagtat ataacaccat caccataatc ataggcgccc atacctctga tccgaataag 2531881 aaccagccgg attggacggc aaagtaactg tggaagaggc cgacaacgag cggaatgccg 2531941 aagttgtaca tttgtttgat gcgtatcccc tttatcaggt cgccctgcgt aaagccgagt 2532001 tttcttaaaa ttgtatagct cggtttttca tcttcacttt cacccatttg tttaaaataa 2532061 aggatacaac ctgatgtaat caggaacgtt aaccctaaga agccgacgat gaacatcacc 2532121 ataccaaaca gtgatttttg cgcagcgctt gtatctagtc ttgataaatg ctcgtttttc 2532181 ttgttcacct gttgaaaaag ctcatttgct ttttccattt gatcgtcatg tttcacattg 2532241 acgccgataa atgtagattg cgccagctga atgcgggggt ctttatcctt gtccagctgt 2532301 ttaaacaggc tgtcatccac aatgacagcg ggcatgcccc cgcttgtaaa cgtgtaggac 2532361 acaagaaact cttctcttaa tcctttatat tttaatggct gcgtctcgtg cttgcttttt 2532421 actttaataa caccagagtc cttgaaaacc attatttttt gcagcaagtc ggtgtatcct 2532481 gagaaaacgg cttctccagc cgccacatcg actcctttta catctttgtc gctaacaaca 2532541 gcaagctgca tattgccggg atcgccctgc atctctttcg gagttccatc cataatattt 2532601 gcaatgtcaa catttgcttg caggacaggt gttgcctttt ttacaaacga gatgttgctt 2532661 tccctcaatt tgttttcaaa taacttggca tctttctcat tcatgaatga aaaatcagcc 2532721 gctacatttt gttcagcggt cttttccgac gagtaatacg agatgtaagc aagagataac 2532781 agcccgatgg cgagcgctga aacggttgta ataatcgtca gcagcagcgc attcgatttc 2532841 attctgaaca tgatcgaaga cagtgacaga acctcagaaa tatttaagta gccgcccttg 2532901 ctttttcgaa tgatattcga gataaacgta actgatcctt tataaaacaa aaacgtcccg 2532961 ataatgacgc tccccagaat gaagctcatc gcaacaaaca gttcattaat ggtcttaaat 2533021 tttccgccaa acagctcaga agacacatag tatcctgtca aaatcaacac gatgcctaaa 2533081 gcgccgatca gcatttggaa aaatgatatt ttcttcactt tgtcttcagt ggaggacgtt 2533141 actttaaaca aagataaaat actctgtttt ttgataaacg tataattcat gatcatgatc 2533201 aaaaggtaaa tgccgcagaa cacaatgacc gtttggacca aggcctgctc agaaaaatgc 2533261 agtttcgcat ccgctttgac atcgacaatt ttgaacagaa tcatcaagac aagcttcgat 2533321 atcgaaaacc cggccgctac cccgatcgct aatgaaccga aatacagcat gacattttct 2533381 gcacttaaga tgcgaaaaat tttatgcttc gtcattccaa ttaattgaaa cagcccgatt 2533441 tctttactcc gtctcttaat aaaaatcgta ttggcatata aaatgaagat cgccactaca 2533501 gccacaagca aaatcgaagc ggttttaata gccgcggctc ccttgattga agccttcact 2533561 tcgttaattg ctggatcata ctgcagcgtg acaaaggcga aataaagcgc cacgctaaag 2533621 atgagcgcaa acacatacaa atagtaattc cggagattct ttttcaaatt tcgcaggatg 2533681 agctgattaa tgttcatgct gcaccccgcc taacacgcct tgcgttttca taatatcctg 2533741 gaaaaacgtt tgcctgtcct ggcccccttt attcagctgt gtatacattt gcccgtcctt 2533801 aataaaaatg actctgccgc agtagctggc agcgacggga tcatgggtaa ccataataat 2533861 cgtcgcgttg cgtttttgat tgagctggct cagcttattt aatagatcgg aggccgattt 2533921 cgaatcgagc gcgccggtcg gttcatcagc gaaaataatg ctcgggtcat gaataaacgc 2533981 tcttccagcg gatgttctct gcttctggcc gccggaaatt tcattcgggt atttatcccg 2534041 caattcatat attcccagtt ccttggcaac ttcctcaaac ttgcgattgg cttccttttt 2534101 tgatagtttc gtgatcgata aaggcagaag gatattctct ttcactgtca atgtgtctaa 2534161 caaattgtaa tcctgaaaga taaagcctaa atgctgtttt ctaaattcag ccagctgctt 2534221 ttccttcata gccgtcatgt catttccatt aatatgaatg gttccgtgac tgacctgatc 2534281 gattgaggac agaacgttga gcaaagtggt ttttcccgac ccggaagcac ccataatact 2534341 gacgaattcg cccttttcaa tgtgaatatc gatgcccttc agcacttcct gtttattcag 2534401 cttgtttcca taactttttc gaattttatt cgcttctaaa atcaccattt acgcagtctc 2534461 ctttatattg gataatctca ttataaaaag gaatgccggg cttttccttc gatacggcga 2534521 acaaaaaaga aaagcatgtg acattttcgt cacacgctta tgacatgttc aaattgattc 2534581 cgtattggaa aggttaatgt aaaaactgtt cccgcaccaa actccgactc aacatcaata 2534641 tggatcaata acggcgccgc tgcttttttt gccaagtaca gccccatgcc agttgacgct 2534701 tgatcatggt gatccgttgt ggatgtaaac cctttatcaa aaatacgcgg tacatctttt 2534761 ggatcaatgc ccctgccaca atctttcact tggagctgcg tctgttcccc tttttgaaag 2534821 cttttgatct cgatttcaga ggcttcgctg tatttcaccg cgtttgtcag cagctgcctg 2534881 atgataaacg ccagccattt tgcatcgctc agcacttctt tggcctcgag ctgtatgtca 2534941 aaaccgatcc ctttttggat acaccacgat tgtaaatctt tgatttcttt aaagatcaaa 2535001 ggctgaagct gaatgaattc tactgacagg tcgttttcaa taaatgaaat gcgtttttga 2535061 tgaagctgct gatcaagaag caggtgaata cgcagccatt catatgacag ctgggatttc 2535121 agtgcttttt cttccattct atcaatgatt aaatgcatcg ctgttaatgg agttttgacc 2535181 tcatggatcc atgccatcag ctcatctttt tcattttcca atgctaagcg atgccgtgct 2535241 gcggtctgct tcaagtgttc tgtttgcccg gcaatgcttc tttcaaccat tgcttcaaac 2535301 ggcgtttccg gttcatttat ggctgtcaca tcgagattgt tctcccatgt tttcaagctt 2535361 ttataaaacg ctgtttcttt ccgatagcgg aaccaaagga atatgataaa aaacaagatg 2535421 cacaaataca ccatataaag tacattccca aatgatatgg aaggatcgac aaaagcaatg 2535481 aacagcatca aagcctgctg aaacaaaaac gcggcaatcc agctccgcct ttcgataagg 2535541 aatgctttaa tcatagaact tgtcctcttc cttcgcgatg tagccctggc ccacctttgt 2535601 ctcgatatat gcaccaagct gcagggcgtc cagttttttt cgcaggcgat tgacattgac 2535661 ggtcagcgta ttatcactaa caaaacgctc atcgttccac aagcttctga tcagctcttc 2535721 ccggctgacg atcttgtttt tttgctctat taattgtttt agaatgaaca tttcattttt 2535781 ggtcagttca acagatcctt tgtcattgct gacgaggttc tgctccgcgt ctacagcagc 2535841 gccgcaccac gttttaatcg tactcggctc cgtattataa tggtgcacac gccggaacat 2535901 cgcttggatt ttcgcgatca gcacatcaaa atgaaatggc ttttgaataa agtcatctgc 2535961 cccgagctgc atggacatca ccatatcagc aggatgatcc cgggaggata aaaagagaat 2536021 cggaacattt gaccgggagc ggatcagacg gcaccaatga aagccgtcaa atttaggcag 2536081 ctgcacatca ataatgacac aatcaggatt aaccgccgca aattcctgca gcacctgact 2536141 gaaatcctga atgccgtata catcatagga ccatcccgtt aaacgatcct tgatttcatg 2536201 aaacagcgat tcatcatctt caatcagcaa aagtttaaac aatcgactca ccgcactttt 2536261 tcctttttta tcaagtgtat agcaaaacgc cagcatgcgc tatagaaaaa gccggctgtc 2536321 tcagccggct cgttcgcatt ataattctct tctcaacgct gtcagcacgt tggttttggt 2536381 agcttttctc gccgggttca ttccggaaat gactgcgacc cctccgcaaa tcacaacggc 2536441 aatgatcaca aggctcgccg ggatgtagga gaatgtgtaa ttcaaatcgc ccgcatcgcc 2536501 accgcttgtg gccgcaagaa tcatcggaac ggccaggttg acaaggtagc tcacgccgta 2536561 agaaatgata atcccaatca cacagcctaa aattccgata tacgcgcttt ccatcaagaa 2536621 cattcggcga atgattgacg ggctcgcccc aatcgctttc ataatgccga tctcttgcgt 2536681 tctctctgtc accgccatcg tcatcgtgtt aaaaatgccg atcgctgaaa tgataactgc 2536741 gatacatccg acaaagatca gtccgatttt gaagaccatg aagaaggtat tggctccctc 2536801 aagttcagta gtcactgatg tgacatagta cccgtcatct gttagatcat ttgtcagctg 2536861 ttccacattc tcaaacttat cagcaaaaac accaatgttc gtttcaacat ttccgccttt 2536921 gaaatctaag aattccgaaa aatctttttt gaattgatca ctgataaaaa tatttgagtc 2536981 ctccatccag tcttgagatg gtttttttgt aataccgaca attttaaagt catatgtttt 2537041 tgtttttgta acatcccctg ttttagaatc tgtcttcgat acacttagtt caattgtttt 2537101 atttagaata tctttcgtat agccctttgg ttcttttata tcttctggat ttccttttgc 2537161 ttcctcgatt tttttgttat attcttccga ttcttttttc gttaataatc tctttgcgaa 2537221 gtcgtatcct actacgattt cattttccga ctttgcgact cttccctttt ccaattccat 2537281 attggccttt aattcatcat tcatattagt aaaaatgaga tttgagcttt catttgtacg 2537341 attgcctaaa gtagctttgt ttggttcata cacttgcgtt ctttctacaa ctgaccttac 2537401 gtgatcatac ttctctaaat cagctttttt aatcggcttg tctccttcct tgcccattac 2537461 gctgactttc gttacaatct gctggctcat tgtcatatct gtaatcgtct tttgaatccc 2537521 aaatccaacg gacgacaaca caaccaaaaa cgcacacgcc attgttgtcg ccagaatcgt 2537581 cataaagacg cgaagcctgt ttttcttcat atttcttctg ataaaatgaa cctgatcctt 2537641 aaacctcaac ggtaattcct ccttttagca caccatcatg aagctgaaat tttgaatgtc 2537701 cgatagaagc gacttcatca tcgtgagtaa tgatcacaaa tgtaatgcca cgctcacgat 2537761 tcagctgctg gatcaattcc agcacttcat gttccgtttc tgaatcaagg cttcccgtcg 2537821 gctcatccgc taagataatc gaaggattta aaatcaatgc tcgagcaata ctgacacgct 2537881 gctgctggcc gcctgacagt tcattcggat aatgagcggc gtggttttcc agaccgacgc 2537941 gtttcagcat gtcctgcacc ttttgcttcc gctcagatgg cttgattcct tttaacgcca 2538001 gcggcatttc cacattctca tacgtcgtta aacccgggat gagctgaaag ctctgaaaaa 2538061 taaacccgaa atggtcaagc cgaaattgcg cccattcctt ttcattaaac cccgtaacat 2538121 cagtgccatt aatgacaatc cgcccttttg tcggcgatat gtagccggaa attaaattca 2538181 aaagcgttga tttccctgag ccgcttcgtc cgacaatgca ggcgatttcc cctttcgcca 2538241 cgctcaatga aacatccttc aatactggaa cttcattctc acggcccttt tttccgatcg 2538301 tgaaagaatg gtcgatatgc tgaacatcaa tcatatgttc tctctccctt acaaaagttt 2538361 cattttttta taaatcgcaa aataactaat caagaaaccg attaccgcac ctgtacccat 2538421 gccaatgaga taaccggcaa agctctcgct tgcagtaaat ccaaaatagc cgaagcccat 2538481 gattcctatg ataataacga tgatctgcac cgggcggtta agcggcttcc ataagaagaa 2538541 atatccgttt ctttcattag acattttaac aaagctaata tagccgatga tgtaaaaaat 2538601 gatagtcatg atagccggaa tgactaaata atatggtgaa ttctcagccc atttcgagtc 2538661 tacataaatt atcggaatga aatactgcac ccatttaggt actggaccat ggataaaatc 2538721 tattgatccg ccaaaaagga tctcgaggtt gatcacaggc aggctgatga gtaaaaacgg 2538781 cgaaatggcc acggtaaatg agactagaag ctgtgcgaaa ctattgcctg tcaaagctcc 2538841 tccggccata accaaagaat aagccagcat gctaacaata atcattccca agctgtaatt 2538901 gtgaaaataa acggcctgat ctggcttcaa aagcatgatc agcaaaacag acaaaacata 2538961 acctatgagc tgcggcacca caatcaccat tccgccggta aggaacttcg catgaaatat 2539021 ctgccctcgt gtatatggaa ggcttaatgt aaaatcaaag aagctcttgc tacgttcaat 2539081 cccaagctgg ctgaccgcca aaacgactcc ccaaatccaa aacaatgaga taaatgagct 2539141 atttaaataa tcaacgctga atacgcaggg gccgacccaa ttttcttttc cagtgacaca 2539201 gccttgatag atgagataca tatttaaaat tgataatgga ttacctaata taaaaaccaa 2539261 aatggtgata actaaggcga ctttattctg ccgccactct ttgtaaagca gtccggaatc 2539321 cggcaactca cttccctcca aacctaaggc atttcttaca cttttgtttt cttataaata 2539381 gagaagtagc tcacaaagaa tccagccact gctccaatga tcatacccaa aatataacca 2539441 ataatggaat gtccggtata gtatccaaat aaaccaaatc caaggatgcc gaaagccata 2539501 accagaattt gcaccgggcg atctaatctg ttccataaga aaaagtgtcc gttccgttca 2539561 cttggaagct tcttgaagct tataaagcca atcaagtaaa atagcatgct cattacggct 2539621 ggaatcaata aaagatattt actgttaatc agccattcat ttacaacgta actaatcggt 2539681 actaggttcg ataaattgct tgccagagag aaataactct caggggaagg gaatatttcc 2539741 catatattcg caccaaaaac aacttctagg tttccaaccg gcaatgcaat aattaaatac 2539801 ggcaatatag ctgctgaaaa cgccgttaac agttgggcaa aagcatttcc agttaacgct 2539861 ccggcggcca tcaccagtga aaaagccata aaacttatca cgattactcc aatgctgctg 2539921 tgctcaaaaa agtagacgtg ttcagggtta tagacaagaa tcagcagcca tgcaagtaaa 2539981 aagccaatca attgtgacag cacaatcaca aaaccgccta accaaaattt tgtctgaaaa 2540041 atttggcttc tgttatacgg gaggcttaat ataaaatcca tcgtgccttt cgaacgctcc 2540101 attccgagga agcagaccgc caaaatgaca cccggcaccc agttgatatc tatcagattg 2540161 cttatggaat aattcacaat aaaatcacaa tattgcgggt cttggcgatc aagacaccct 2540221 tgataagaca aatacgtatt aacgatagaa agcggatttg ccaatactaa aaacgcgata 2540281 cttaacaaaa tcaccacttg attctgcttc cactctcgat agaggagacc tcggtctacc 2540341 atctccgctt ccctccaaac ttcgcaatga acacttcttc caggttgaca ggaagctcat 2540401 tccacacttt tggcttcagc tctctcaaaa agctcttttt ctcctcatcg cttttcggaa 2540461 tcagcactgt gtaaaacacg ccggcctgat cgagcatcgg aatgttttgc tctctgatgg 2540521 ccaaattgac atctgtatcg aaggccattt gaattttaat gtattcttct tttaactcat 2540581 caagatccat gacgttggtc aggctgttat cttcaagaaa accaattcgg ttgcacatcc 2540641 gctctatgtc ttcaagccgg tgggacgtaa tcaggatgct cgtatcacgc tctgccactt 2540701 catcgaccat cagctgcagc acatcatgcc ttgtcaccgc atcaatacca tccgtcggct 2540761 catcaaggag gatcagcgcc ggtctcgccg caaacgacag aacgagcgat agctgctttt 2540821 ttaagcctgt cgacagctca cggtattttt tcgtttccgg aatttcgtat ctgttcatca 2540881 gctcattcgc gtacgtgaca tcaaatttcg gatatattct tctcaaaata tcgactaact 2540941 gcttgtatgt atacttatcg taaaacggat tttgaacagg catgtagatg atattttgtt 2541001 tgactttcgg gtgctttttg atttctacgc cgtcaaataa aatcgttccg ctgtcagcga 2541061 aaatgatttg ctggattaag cgaagcatcg tcgttttgcc cgatccattg cgtccaagca 2541121 atccaaagat ttctcctttt tcgattgtta atgaaacatc ttttaatact tgattgccgt 2541181 caatcgcttt tgacagctgc cgcagttcaa tcattttttt tgcctccctt cacatcagcg 2541241 ctgatttcct ttatccattc gtgcagtttt tccagctcaa cccctgcata gtgtgcatcg 2541301 atgatgagct gtttgagttg ctctttaatc atcgtcatct tcccttcaac cagtgtcgtt 2541361 tttgcattct ccgatatata ggtccctctg ccccgcagcg tttcaataat cccctctcgc 2541421 tcaagttctt tatacgcttt gctgacagtg ttcggattcg caataatgat cgttgccaat 2541481 tctctgacag aaggaagctt atcaccaggc ttcatgatcc ctttcaaaca aagctctttc 2541541 atttgctgaa taatttgttc gtaaatgggt gttgagcttc ttggatcgat ttgaatcatt 2541601 tacttcccta ctttctatac gatctgaacc ttttatagat aaaaatgatc aattatactt 2541661 ttttgccatt caaaaccgat catcacaaga acaagaaaaa aagaacaagc gatcacagat 2541721 gccgcaatca gcattggcac gttacgtttg tttcgttttt tatgtttcat aactgcctcc 2541781 cttaatgtca atatataaat gattttatat tagtgtctat agtgtattac ttcaattagt 2541841 acacttaata caataaatac tttgactcac aaagtcaatc ctttttttac aaaaaaacgg 2541901 acccttttaa aagggtccgt tttcctacac atcaagaggg tgctgcagga tcatattatt 2541961 ttgcaaagat tgaagctgaa gtctcattct gtacagctgt tctctctgct gatcatttga 2542021 cgacagccat agtttattca aggcatttac cgcatcttct agctgcattt gtgcatcact 2542081 atattcttga tcgttataat gctcttgttt agaagcgatt ttcagctgtt cttcagcata 2542141 atcataggcc tgcatacatt gctggagatg ttcatctact gattgtcttg ttgccacagt 2542201 aacccctcct cttggtaatg gaaatcatcc atcattcata ttgtagcctc atctgacttt 2542261 attcaataaa gtaatttatg gtcgatattc atttgttctc ttgtgaaatg cgtgctacaa 2542321 ttttaggatg caatcgtacg caaggaggca catgaattgt gatgcagaac aatccttttc 2542381 cttattcaaa tacggaaaaa cgctatcata cattgaatta tcatctcaga gaacatttcg 2542441 gccataaggt gtttaaagta gcgcttgacg gcggttttga ctgtccaaat cgggatggca 2542501 ccgtagccca cggaggctgt acgttttgca gcgcagcagg ctccggagat tttgctggaa 2542561 accggaccga tgatttaatt acgcaattcc atgacatcaa aaaccgcatg cacgaaaaat 2542621 ggaaggacgg caagtacatc gcttattttc aggctttcac aaacactcac gccccggttg 2542681 aggtgcttcg tgagaaattc gaatccgtcc tcgccttaga tgatgtggtc ggcatttcga 2542741 tcgccacacg cccggactgt ctgcctgatg atgtcgttga ttacttggca gagctgaatg 2542801 aacgtacgta tttgtgggtg gagcttgggc ttcaaacagt tcatgaacgg actgcacttt 2542861 tgatcaaccg cgcacatgat tttaactgct atgtggaagg cgtcaataaa ttaagaaaac 2542921 acggcatacg tgtctgctcg catattatca acgggctgcc tttggaagac cgggacatga 2542981 tgatggaaac ggcaaaggcc gtcgcagatt tggatgtcca gggcattaaa atccatctgc 2543041 ttcacctact gaaaggcacg ccgatggtca aacaatatga aaagggcaag ctggaatttc 2543101 tttctcaaga tgattatgtg cagctcgtct gcgatcagct tgagatcatt ccgcctgaaa 2543161 tgatcgtcca ccgcattaca ggtgacggac cgattgagtt gatgatcggg ccaatgtgga 2543221 gcgtcaacaa atgggaagtg cttggcgcca ttaataaaga gctagaaaat cgaggcagct 2543281 atcaaggaaa gttctttcaa cggcttgagg aggaatcagc gctatgattt tgaagaaaat 2543341 tcttccttac agcaaagaac tgctgaaaat ggccgcggga gagggagata ttgtcgtaga 2543401 tgcgacaatg ggcaacggac atgatacaca gtttttagcg gagcttgtcg gtgaaaacgg 2543461 ccatgtatac gcattcgaca tccaagaatc agccgtggcc aatacaaagg aacggctcgg 2543521 tgacatgtat caagcgcgaa caacgttatt tcacaaaagc catgataaaa tcgctgaatc 2543581 cctcccgcct gaaacacatg gcaaagtggc ggccgcggta tttaacctcg gctatttgcc 2543641 gggcggggac aaatcaatta cgacaaacgg cagttctacg atcaaagcca ttgaacagct 2543701 tctcagcatc atgaaagacg aaggtctgat tgttctcgtc gtctatcatg gccacccgga 2543761 aggcaaagct gaaaaaaacg acgtgctcga gttttgccgg gacttggacc agcaaacagc 2543821 ccgtgtatta acatacgggt ttatcaatca gcaaaatgac ccgccattta ttgtcgccat 2543881 cgaaaaaaaa gctcagatca gcaaatgatt tgagcttttt tctttgaatt tttcatccag 2543941 gacatttttt gaaatttccg gtaggctctg ccgttgatat aaaagaaaag ggaggttttt 2544001 ccgctggctt tgatcagctt ctttgcgagc cggacctgct tcgtcttact ttaccatttt 2544061 tcaaattata tttgaaagca ataaccatcg ttaacccgga cgtcatacag ttcgggtttc 2544121 gatttttcca taaaacgttc acatatagca tgaaacgtat gacttttatc ttatcacaaa 2544181 actataaaca gcctctgcaa aaacacatac ctattctttc ctgttctcta ttttctatga 2544241 gcacacacaa aaagagccca ctgggagctc tttttgtcag ctgatatttc gttcgctggc 2544301 agcagccgca ttttttttat gaaacccttt tccatagtac acagccagca agatgagaaa 2544361 ccatatcggc ccgataatca cggctactct tgtatcaggg ctgtaagcca taagaatgac 2544421 gacgaatgct agaaatgcca atgacacata agacgtaaac ggaaataaag gcattttgta 2544481 ctttaattgt ttcttttctt ccggcttcaa acttttcctg tattttattt gagaaagcaa 2544541 aatgattgcc cacgtccaaa tcgctccgaa cgtcgcaata cttgtaaccc aagtaaatac 2544601 cttcgcaggg acaacatagt ttaacagcac tccgactaat aaagcgcccg ctgaagccag 2544661 aacagcttta cccgggatgc cgcctttcgt cagctgacca tatgcttgtg gcgcctcttt 2544721 ctgttccgcc aagttaaaca gcatccgccc tgtgctgaaa ataccactgt tgcatgaaga 2544781 cagcgcggct gtcaacacga caaagttaat gatacctgcg gccgatggaa tgcccacttt 2544841 ttgaaatgtg agaacaaatg gacttccttg agagccaatt tcctgccacg gataaataga 2544901 cataatgaca aataaagcgc ctacataaaa aatcaaaatc cgccaaaata ctgtatcgat 2544961 tgctttggct aacgattttt gcgggttttt tacttcgcca gccgtcaccc cgatcatttc 2545021 aatccctaaa taggcgaaca tgaccatttg aagagacaat aaaacccctt ttaatccatg 2545081 agggaaaaat cctccgttgt tccacaaatt gctgattccg gttgcaatgc ccccattgcc 2545141 gactcctgca ataatcatca ataaaccgac agcaatcatg gataagattg caacaatttt 2545201 aatcaatgcg aaccaaaatt ccagctcgcc gtaagctttg acagccagga aattaacacc 2545261 cgtcataatg accagtgccg ataacgccca aatccagttt ggcacgtccg gaaaccagaa 2545321 ccccatatag atgccgacag cagtgatttc ggccatacag gtgacaaccc ataaaaacca 2545381 gtagttccaa cctgttaaat agcctgcaag cggtcccaaa taatcacgcg catacctgct 2545441 gaaggagcct gcgaccggtt tttgaatggc catttcccca agcgctctca taataaaaaa 2545501 catgaccagg ccgcttgcgg catacgctac caaaatacca ggccctgcta attgaatagc 2545561 tgatgcggag ccgaggaaca accctactcc tatagcagct cctaaagaca ttaaagaaat 2545621 atgcctttct tcgagtccgc ggtgcagctc ttgtttttgt ttttgcatgc ttcttctccc 2545681 ctagaaaaaa atatcattat atcatttttc tgaatattcc gtacggattg ggtaaatcaa 2545741 tgatgatgga gaaataaaag gataacaaca aggctttcga ctactcgaaa gccttgttgt 2545801 ctgttacaca aagatgactt ctttaggctg atggctcagc tcttcaggca tataccgttt 2545861 ttcaatattg atgctgtgcc agatcataaa gattagcaca gtccaaattt tacggctgtt 2545921 atcagccttg tccgcacaat ggtcttcaag aagctgaagg acataatcct tatggatata 2545981 agcatccgtt tggctttctt gaataatatt ccgcacccat tcgttcattt cgtttttcag 2546041 ccaatgacgg atcggtacag ggaaaccaag ctttttgcgg tttaatacgt gctcaggcac 2546101 aattccttca gcggctttgc gaagaagata cttcgtcgtg ccgttcttcg ttttcagctc 2546161 atcaggaatt tttgaagcga cgtcgaatac gactttatcc aagaacggca cacgcagttc 2546221 caaagaattc gccatcgtca ttttatccgc ctttaacaaa atgtcgccgc gcatccaagt 2546281 gtggatatcg acatactgca ttttgttgat atcgctgtac gagctgcttt ctgtaaagta 2546341 agtcttcgtc acatcgcgat atgaaaggtt cggattataa tgcttcaaca gctgcttttt 2546401 gacagactct tcaaagattt tcgcgttacc gatataacga tcctgaagcg gagtgcagcc 2546461 gcgctcaagc aggctcttcc ctctcatacc ttcaggcata acggcagcaa cgtgcagaag 2546521 catctttttc aagccggacg gaatccgttc aaacggttta agcgaaagcg gttcacggta 2546581 aatgttatat ccgccgaaga gctcatccgc tccttcacct gataaagcaa ccgtaacatg 2546641 tttttttgct tcttttgcaa caaagtacaa cggaatcgct gccggatcag caagcgggtc 2546701 atcaaaatgc catacgatct tcggaagctc attcatgtat tcctcaggcg aaatgacttt 2546761 gctgatattt tcaatgccca gcgccgctgc cgtttctttc gctacatcaa cctcactgaa 2546821 gccctgctgt tcaaagccga cagagaatgt ttttaagctt ggatgaaatt ccttcgcaac 2546881 agacacaata aaggaagaat caatcccgcc agacaggaac gaaccgacag gaacgtcact 2546941 tctcatatga acgtttacag agtcatagat cgcgtctcgg acttctttca caagcttgtc 2547001 ttcttcagtc tgaaccggct tgaagttcgc tttgaaatac gttttgaatg tgatatcgcc 2547061 gtccgggcgg attgtgaatt gtgaacccgg ctctactttt ttcacatggg catcaagcgt 2547121 gcttggttca ggaacaaatt ggaaagacat gtactgctgc aatgcctctt tatctatttc 2547181 aatatcattc tgagcaacca ttaaactttt tctctctgag gcaaaataaa cctgatcatt 2547241 gatcgttgtg tagtacaacg gtttaatgcc gaatggatct cttgccccat aaagcacatg 2547301 atcgttttta ttccaaatca gaaaggcaaa cataccgcgc agtttggacg ccgcttcttc 2547361 tttatagtga cggtaagtcg caagaagaac ctctgtgtcc gaatccgtgt tgaatgtgta 2547421 cccctttgct tcaagttctt ctctcagttc gatatagtta tagatttctc cgttaaagat 2547481 aatccaatat gtttcatctt catatgataa aggctgtcca ccattttcta catcaataat 2547541 gctgagccgt ctgaatccga agccgacgtg ctcatcatgg aaatatccat cactgtcagg 2547601 accgcggtga acgatcattt ggttcatttg tttgattagt tcttcttgat cagcggtttg 2547661 agctaacgga tgcttgttaa aaaccccgac aaatccacac atagtattgc ctccataatt 2547721 aaaattgtca tcattgaacc cctatttata gacgctgtga atagtatttg gtttcacagt 2547781 tatgtaaaaa aataaacatg aatacaacga taaaaaaggg aaagccgctt aaccagtaag 2547841 cggctataaa attattctcc taacgcttct ttacgcagct gctccgcttt gtctgtgcgc 2547901 tcccatggaa ggtcaacatc gtgacgtcca aagtggccgt acgcagcagt ttgtttatag 2547961 atcggacggc gcaaatcaag cattttgata atgccggcag gtcgtaaatc aaagttattg 2548021 cgaacaactt caatcagttt ttcctcagaa gcttttcctg aaccgaatgt gttgattgag 2548081 attgacacag gctgtgcaac accgatcgcg taagcaagct gtacttcgca agaatcagca 2548141 agctcagccg caacgatgtt tttcgcaacg tatcttgccg cataagctgc agaacggtct 2548201 accttcgtcg cgtccttacc tgagaacgcg cctccgccgt ggcgtgcata gccgccgtac 2548261 gtatcaacga tgattttgcg tcctgtaagt cccgcatccc cttgagggcc tccgattacg 2548321 aaacgtcctg tagggttgat gaaatatttt gtttcttcat caatcagctc ttcaggaaca 2548381 accggattga ttacatgttc tttaatgttg cgctgaattt gctcaagtgt aatttcaggg 2548441 tgatgctgag ttgaaataac aatcgcgtca atgcggactg gtttgttatt ttcatcgtac 2548501 tcaaccgtta cctgtgtttt gccgtcaggg cgaaggtacg gaagaatatc ttctttacgg 2548561 acttcactta ggcggcgggc taatttatgg gcaagtgaaa ttggaagagg cataagctct 2548621 ttcgtttcgt tgcacgcata accgaacatt aatccttggt cacccgcacc aatcgcttca 2548681 atttcttcgt cgctcattgt gccttcacgg gcttcaagcg cttggtctac gcccatcgcg 2548741 atatcagcag actgctcatc aattgatgtt aaaaccgcac aagtttccgc atcaaatccg 2548801 tattttgcac gtgtgtatcc gatttcttta atggtttggc gaaccgtttt cggaatgtca 2548861 acatacgtag aagttgtgat ctctccgctt acaagaacca aacctgttgt cacagatgtt 2548921 tcacaagcaa cacgcgcgtt agggtctttc tttaaaattt catctaaaat gctgtcagaa 2548981 atctggtcac agattttatc cggatgcccc tccgtaacag attctgatgt aaataaacga 2549041 cgatttttac tcatgatttg cttcctcctg cacaaggcct cccgaaagac cttgtatata 2549101 tgatacggaa ctcgctccct cttatacaat gtacagttat attagagaat gttaattggc 2549161 atatttatga aataaaaaaa ccttttccat cgaggaaagg gtttggtctt tgtgcctttc 2549221 actcttatcg ctcaaggaat catacaacct tgcaacaggt tagcaccttg gttgtctcac 2549281 tcagttgaac ataataaata acagagaaac cggttgctgg gcttcatagg gcctgtccct 2549341 ccgccagctc gggataagag tatccgctca atgaaatatc ttatcgtaaa agggtttgca 2549401 atgtcaatat gattcagaag aaataggcac ctatattgag ggaaaacaat ggaaatgcac 2549461 acacaaaaaa caataaatag tatagactat ttgaaaatat atgttatact aattcacaat 2549521 tagcaaaaca caaaaaacga taaaggaagg tttcatatga actcagttga tttgaccgct 2549581 gatttacaag ccttattaac atgtccaaat gtgcgtcata atttatcagc agcacagcta 2549641 acagaaaaag tcctctcccg aaacgaaggc attttaacat ccacaggtgc tgttcgcgcg 2549701 acaacaggcg cttacacagg acgctcacct aaagataaat tcatcgtgga ggaagaaagc 2549761 acgaaaaata agatcgattg gggcccggtg aatcagccga tttcagaaga agcgtttgag 2549821 cggctgtaca cgaaagttgt cagctattta aaggagcgag atgaactgtt tgttttcgaa 2549881 ggatttgccg gagcagacga gaaatacagg ctgccgatca ctgtcgtaaa tgagttcgca 2549941 tggcacaatt tatttgcgcg gcagctgttt atccgtccgg aaggaaatga taagaaaaca 2550001 gttgagcagc cgttcaccat tctttctgct ccgcatttca aagcggatcc aaaaacagac 2550061 ggcactcatt ccgaaacgtt tattattgtc tctttcgaaa agcggacaat tttaatcggc 2550121 ggaactgagt atgccggtga aatgaagaag tccattttct ccattatgaa tttcctgctg 2550181 cctgaaagag atattttatc tatgcactgc tccgccaatg tcggtgaaaa aggcgatgtc 2550241 gcccttttct tcggactgtc aggaacagga aagaccaccc tgtcggcaga tgctgaccgc 2550301 aagctgatcg gtgacgatga acatggctgg tctgatacag gcgtctttaa tattgaaggc 2550361 ggatgctacg ctaagtgtat tcatttaagc gaggaaaagg agccgcaaat ctttaacgcg 2550421 atccgcttcg ggtctgttct cgaaaatgtc gttgtggatg aagatacacg cgaagccaat 2550481 tatgatgatt ccttctatac tgaaaacacg cgggcagctt acccgattca tatgattaat 2550541 aacatcgtga ctccaagcat ggccggccat ccgtcagcca ttgtattttt gacggctgat 2550601 gccttcggag tcctgccgcc gatcagcaaa ctaacgaagg agcaggcgat gtaccatttt 2550661 ttgagcggtt acacgagtaa gcttgccgga accgaacgtg gtgtcacgtc tcctgaaacg 2550721 acgttttcta catgcttcgg ctcaccgttc ctgccgcttc ctgctcacgt ctatgctgaa 2550781 atgctcggca aaaagatcga tgaacacggc gcagacgttt tcttagtcaa taccggatgg 2550841 accgggggcg gctacggcac aggcgaacga atgaagcttt cttacactag agcaatggtc 2550901 aaagcagcga ttgaaggcaa attagaggat gctgaaatga taactgacga tattttcggc 2550961 ctgcacattc cggcccatgt tcctggcgtt cctgatcata tccttcagcc tgaaaacacg 2551021 tggaccaaca aggaagaata caaagaaaaa gcagtctacc ttgcaaatga attcaaagag 2551081 aactttaaaa agttcgcaca taccgatgcc atcgcccagg caggcggccc tctcgtataa 2551141 aaaacaaaag ccaagagcaa ttatgctctt ggcttgtttt aattgacgga atgcaaagaa 2551201 gtcagcttgt atgtaatgat ggtccggcct tcttcccatt gaagcttctg cacttcagct 2551261 gtgcctgact tttcgccaaa ctttgttttg cgtacatcca ttggaatctc catcggatat 2551321 actcggtatc cgtccttctc taacgtgaat atattttcat ctatgcgaac ttcttttcct 2551381 tttgtcacaa tcagtgtatt aaattcaaca ggcattccca aagtgaaatc ccctttcgtt 2551441 ctcttttttc tttatcataa catatttcac tgtcagcggt ttttcatcca ttgtgtgagc 2551501 tgccgcacga tacgccggtt ttcttttggc gggaaataat gtgtgaatgt actgtagtac 2551561 catgtttcca ccggcttatg cagttgtttt agcttctctt ctaataaata ggaatgctga 2551621 atcgaaacat tttggtcttt ttctccatgg attaacagca cgggagcctg aattttgttt 2551681 acttggtcaa acggtgtcct ccattgatat tcctcaggca cctttttcgg tgttccgccg 2551741 atgactcttt tcatcattcg ccgcaaatcc tgccgctcct cgtatgtaag aatcatatca 2551801 ctgacgcctc cccaggaaac aaatgaagct gcctgcccgc ccatttcgat cgcagtgagc 2551861 attcccataa ttccgccgcg ggaaaaaccg aagatatgga ttctatcctt cttgacattt 2551921 gggtgctgct gaagcaggcg aaaagcagaa aatgcatcct ccctgtcttc tccggcaaaa 2551981 tcctcattgc cttctcctcc ttgattgcct ctgtaaaaag gagcaaacac cacaaaccct 2552041 tgggatgcaa actggataat ccggcccggc cgaaccatgc ccacgctttt aatcccgccg 2552101 cgcaaatata aaaatccgtc atattgtccc ggttccgccg gctcagccag aagcccctta 2552161 acccgtaatc catttgacag atagcagatc gtatacaaac gcacatgctg gcttggcgac 2552221 ggaaatcttc ttttctctac aatcaaaaca gccgcctcct tttttctata tgctttcctt 2552281 actccaaaat tacatccgga gaacctggtt aggcattcac acatttttat acccatcata 2552341 cgatatgtaa agcaaaaaag gatattaact tgatgcgaaa taaggaggtt gtctatgtga 2552401 acagatggtt aaggctgggc ttcgcctgtg tcggcagtat ctttctgatg ttcgccctgg 2552461 cggcttgcaa gcaggaagaa acgctcacca aagtcaaagt agctgaagtg acccattcaa 2552521 ttttttacgc acctttatat gttgctgagt ctaaaggttt ttttaaggaa gaagggcttg 2552581 atgtcgatgt gaatacgacc tggggcggag ataaaacgat gacatcgctt ctttccaacg 2552641 gctccgacat cgcgcttgtc gggtcagaaa catctattta tgtcgaagcg caaggggcta 2552701 aagatcccgt cattaatttc gcccagctga ctcagacaga cggaacgttt cttgtcgcga 2552761 gagaagatgt tgaacacttc gactgggatc agctgaaagg aaaaacgttt ctcggtcagc 2552821 gaaaaggcgg catgccgcaa atggtcggcg agtatgtact gaacaaacat aagattgacc 2552881 cgcataagga tatagacctc atccagaaca tagacttcgc caatattgcc aatgcgtttg 2552941 cttctggaac cggtgagtat gtacagctct ttgaaccgca ggcttctctc tttgagaaaa 2553001 aaggcatcgg ccatatcgtg gcttcattcg gagaagaatc aggagaggtt ccttatacga 2553061 cttttatggc gaaacaaagc tatttgaaga aaaatgaaga cacagccgtc aagtttacaa 2553121 aagccattta taaggcgcag cagtgggttg aaaatcattc tgcgaaggac atcacagatg 2553181 ccattaaaga tgaatttgat gataccgacc cagacgtcat cgaaacatcc attgaacgct 2553241 ataaaaaaca gcattcatat tcaccagacc ctctgcttaa cgaaaaagaa tgggagcttc 2553301 tccaaaccat tatggataaa tcgggagaac tgccgaagca cattccatac aatcagcttg 2553361 taaataaaga aattgctgaa aaagtcacct cggagaaata ggaggcgcca tctatgtctt 2553421 tcttacatgt cgaccatgta acccatactt atttttctat taaagaaaaa acaacggctg 2553481 tgcgggatat tcatttcgat gccgaaaaag gcgatttcat ctcatttctc ggcccaagcg 2553541 gctgcggaaa aacaacattg ctttccatta ttgccggttt gattgagcca tcagaaggca 2553601 gagttctgat tgaaggccgt gagccgaatc aaaaagaaca taatattggc tatatgcttc 2553661 agcaggatta cttatttccc tggaaatcta tcgaggaaaa tgtgcttctc ggtttaaaaa 2553721 tcgccgacac gctgacagaa gaaagcaaag ccgctgcact cggtctattg ccggagttcg 2553781 gcctcataga tgtggagaaa aaatatccga aagaactgtc aggcgggatg cgccagcggg 2553841 ctgcgcttgc aagaacactt gcgcctaacc ctagtctgct tttgctggat gagccatttt 2553901 ccgcgcttga ttttcagaca aagctgtctt tggaaaacct ggtattccgc acattaaagg 2553961 aatatcaaaa aacagcagtg cttgtcactc atgatatagg ggaagcgata gcgatgagcg 2554021 atacgatctt tttattttca aatcagccgg gcaccatcca tcagattttt accattccta 2554081 aggaattggc cgcgatgttg ccttttgacg cccgtcagga accttccttc cagacactgt 2554141 ttcaaacgat atggaaggag ctgaattctc ttgagaaaca gcaaagaaac cattgatctg 2554201 cttcacgagc agtatcaatt caaacagaaa aaggaaaagt ggaaggtcca ttcctttcag 2554261 cttgccatat ttattctctt tttctcgggc tgggaaatct ccagcaggca gggctggatc 2554321 gatccgctga tcttcagctc tccatcagct gtgtggcgat tattgctgga gaaacttggt 2554381 gacggttctt tactgtcaca catcggcgtc actttatttg aaacggtgct tggctttttg 2554441 ctcgggacgt ttatgggcac gtgcctagcc gctttgttat ggtggtctaa ccgacttgcc 2554501 agaattttag atccgtatct tgtgattttg aacgcaatgc cgaaagtggc cctgggcccg 2554561 atcctgattg tcgcgctcgg tcccagtttt atcagcatca ttgcgatggg agccatcatc 2554621 agcgtcatta tcacaaccat cgttgtctac accgccttcc aagaggtcga cgaaaactat 2554681 acgaaagtca tgaaaacatt cggcgcaaaa aagtgggtta tttttaaaga agtcatactg 2554741 cctgcatcct cccccgcgat tatttcaaca ctaaaagtga acgtcggttt atcatgggtt 2554801 ggcgttattg taggggaatt cctcgtttcg aaggtcggat taggatatat gattatttac 2554861 ggattccaag tcttcaattt tacactcgtc ttcttaagcc tgctgatcat cgccatcttc 2554921 gccactctga tgtatcaggg cgtcgagctg ctggaaaaga aatggacgaa ggggaggaca 2554981 taaaaaaccc ggcacatgtg ccgggttttt tattcaatcc atccagattc tttcagtttt 2555041 ttcaagctga tcggaagaac ggaatccttc ataataaagc tgaatttttt attgcgggaa 2555101 aggttctccg gcagctcgtg aaacaaaacc gggcctttcg tttcaaagta atcagcctgc 2555161 ttttcaagct tttctatatc tgcaaaatat atatttttta caatcacttt ttcttttccg 2555221 agaactttat actgtccgag atacttgagg cttttgactc tcgcgcccgt ctcttccttt 2555281 acttcccgga gcgcagcctc ttctgcgcac tccatcggct ctactttccc gcctggaaac 2555341 tcatagcctc tgtcctcatg ttctgttaaa agccatttgc cgccaaaacg gcaaatcacc 2555401 cagacatgct tcgggctgtc cgagaaaggc tgatcgtcaa aggaaagctg aacagtattc 2555461 tgataataat ctttaaactc gtacatgttt atccctcaaa tccgttccta gctatcttcc 2555521 atacatcata ccacagttac gtttcttcgg aagcctttta tcaaaaaata agggaaaccc 2555581 agcacgccgt caggttctgc atgcagacta gctcgtacag tttttttgcg atacttttgc 2555641 cggaaagtgc gaccgacgct ctgggcttta ttatgacccg cgaacaggga aaagttacgg 2555701 tttgcgctta aatttatttt ttaacgtttc taaaagatcg acaagcatct gaggaaccgg 2555761 tatgccaaga gagctggctg tcacaacaat ttgcacagat tcataaagaa tataaaacat 2555821 aatagccaag tcacgaattg atccctgtgt attcagcagc tgatcaaaaa agtggcatac 2555881 agagatcaga gccagcgtga ctaatttttt gacaagccgg gcaaatacct ttttaaatga 2555941 cagtttgtga ataatggttt ccttcaaagt cgtactgata aattcaattg ccataagaga 2556001 gagcaaaatc agaaatgaat actgaaaacc tccaaagaaa aaacccgctg ctgaaacgct 2556061 gactgctaaa aacgaaaaga tgccaaagtc tctatccatt tatcccaaca tcctttcaca 2556121 gaaacggcct tacgatattc tatggtaaac aagccgaacg gattggattt ttcagaaaaa 2556181 tggactggtt gtcgcctatt tttcagatac aaaaagaaaa gccggacgtc ttttttaaga 2556241 catccggccg ttctattttt gaacttaacc taggtaagct tttagcatcc agttatgttt 2556301 ttcaatattt tgatggatcg caagaagcat gtcccctgtt gtttcgtcac cgacttcatc 2556361 agctaaatcc atgccgtttt tcagctcttc cgcgatgact gtgaaatcat catatacgct 2556421 ttgaaccatt tgttcagctg tttcatttcc agcagcttct ttgacagaag ccgtttctaa 2556481 ggattccttc attgttgcaa tcggttttcc gttcagcgcc aaaagacgtt ctgctaagtc 2556541 atcaatataa gttgctgttt cgttgtacag ctcctcaaac ttttcatgaa gagtgaagaa 2556601 atctttccct ttcacatacc agtgataatt atgtagtttc acatacatga ccgtccagtt 2556661 ggctacttgt ttgttcactg cttgaatcaa ttgttctgac atggtatctc ctccttgtta 2556721 tatgactatg tataccctta atatcgtacg ctaaaacctc ttttttaccc ttatctgtca 2556781 cgatttcttc tattatgcta caattgttaa aaaacgggag gtggaatgtc atgacgcttc 2556841 tcattacgat aagtattttg attgtgctgg ctgttttgct tgtaaccatt tggacgactg 2556901 taaaagccta taatgtaaag cataccattg atccaccaca agaaaatcac tctgattcac 2556961 acaatcaatg atgatgtgaa tgctcctctt ctgactgatt gctggcagca tcggcgtctc 2557021 cgacttggac ttttaaggtc ggcatgctat gctgtttttt tgctgtgaca tgagattgga 2557081 cagtgtatac accatcttcc ttaaacgtcg tttccaatcg gtatacgcct ttttcttgtt 2557141 tcaccttaaa catttggctt gcgtcttttt ccccttcttt ccatacttca aactctactt 2557201 catcggcatc cgtcacagct tcatcaccat atgatacagc tgcttcataa gcagcgcttt 2557261 ctccgggatt tactttttca ggcccggtca gcttgacatc caaaacctcg ggcgtctcag 2557321 ctgtatttgc tttactttca ccagatccgc atccattaag caataaagca gaaaaaagca 2557381 gaacaaccaa catctttttc atgccatcac cctttcatcg tttacctaaa tagtagcaaa 2557441 cgcttacagc aaatggtaca caaaatatga gacgtcacaa aaaagacctt tttgcttaag 2557501 cgcaaaaagg tcctttctat tttagccaaa tacttttagc aattcttctt tatcctgtga 2557561 aagccagaaa cgcattaaac gtttagcgcc ttccagatca tgaagcttcg cttggccgca 2557621 ctgcttttca ttcgcagcag gtatttctgt aatctctacc gcttccttca ttgtgtcttc 2557681 aagcagatca acgatttccg ctgatgtcgg ctctccgctc acaactagat aatagcctgt 2557741 ctggcagccc attggagaaa tatcaatgat atcaaaatga tcgtatttct cagcgtgaga 2557801 acgaatcgta aacgcgagca aatgctcgag tgtgtgaatg gtgtcaggct tcatcgcctg 2557861 tttatttggc tggcaaaaac gaatgtcaaa tttatttaca acgccgtctg ttcccacttt 2557921 atgcacgccg caatgtctta catatggagc aacaaccgca ttatgatcaa gctcaaaact 2557981 ttctactgaa ggcataatgg cactctcccc ttttttaaaa atgtaatttc attataacat 2558041 acttttccga taagaattat tgattaactt ttcaatctgt gttttttttc ttatacttgc 2558101 atcagaaagg ttgctgaaga aacatgaaaa ccctattcat cgctctgatc agaggatatc 2558161 aaaaattcat ctcgcccctg acaccgccaa cgtgccgctt ttatccgacc tgttcccaat 2558221 atggaatcga agcgattaaa acacatggcg ctttaaaagg cggatggctg acaatcaaac 2558281 ggattttgaa atgccacccg ttccatccgg gaggagtcga tcccgttcct gaaaagaaac 2558341 aaaaacatta attgttataa ccgtttacga taagatccag ttttccggtt ttaggatcaa 2558401 tgactaagcc atggaccgga acgttttcag ggaacagcgg gtgatgttta ataacatcta 2558461 cgctgtcttt cacactcgct tccactgaat caaagctttt aaaccattga tcaaagtcta 2558521 caccggagta ctttattgtt tcgatgcgtt cttccggaat ccctcttgct ttgatttttt 2558581 caagcatgct tttgctgctg attttgctca tgccgcaatc gtgatgcccg atcacacaca 2558641 cctcatctgc attcagctcg tacactgcga cgagtatact tctcatgatg cttccgaatg 2558701 ggtgtgtcac aagcgcaccg gcacttttaa tgattttcac atcaccgttt cgcaaattca 2558761 tcgcatgcgg cagcagttca accagacgag tatccatgca agaaagaatc gccatttttt 2558821 tatctggaaa ttttgatgtt tgatactttt catactctct ttgttcagta aatgtcttgt 2558881 taaattcgag aatatcattt agaagactca tgttcgttgt ccctttctat tctttttact 2558941 cttcaatata tcacaaccct tgtttattcg tcataataaa aaaagacaaa ccctcaggcc 2559001 tgccttattt ccccatgtta tagcgttttt tgaactgctc aactcgtccg cctttttcat 2559061 tgaatttctg gcggcctgta taaaacggat gcgtgtcaga gcttacctct actttaatga 2559121 caggatatgt gtttccgtcc tcccactctg ctgtttcatt agatgttttc gtagaggtgc 2559181 ttagaaaacg gtagccgctg ttgacatcct gaaatatcac tttgtggttc tttggatgaa 2559241 ttccttcttt catgggtatc tcctttcaat aaatcgtaat aattacgttt tattttataa 2559301 ccttacaaac gttttgtcaa tcttcttata tccttccctc tgtttcacat cgtaaacctc 2559361 atggcattta agaataggaa gaataatcta accgaggaag caaataataa acccaaaata 2559421 catacagaac gtctttttgg aaaggtggtt tacgattgtg gatgatttag ttttggccag 2559481 aagccttttt ggcacgacga tgggctttca tatcattttc gcaacacttg gagtcggtct 2559541 gccgctcatg attttagtgg cggaattgat ctatcaaaaa acgaaagatg accattatgc 2559601 gatcatggcg aaaagatgga cgaaagcaca agccgttttg ctgggggtcg ccataccgac 2559661 cggaacgatc gcgggcactc agctcgcgct tttatggccg ggatttatgg aagtcatcgg 2559721 ccgggtgatg tccctgccat ttcaaattga aatctatgct ttttttgttg aagccctatt 2559781 catgtcgatt tatgtatacg ctgcagaccg tttgtcacct gcaatgagga ttgttgctgt 2559841 tttctttgtg ttagtcgggg cagcagcatc cgctgttctg atcacgaatg ttcacgcttt 2559901 tgaaggtacg cccgccggtt ttaaaatttt aaacggaaaa attacagatg ttgacccgtg 2559961 ggctgcgttt tttaatccta gcttttttat cactgccggc catgtcgtgc tgtccgcgtt 2560021 tatgactggt gcgtttatcg tggcttctgt tgcggcgtat aaaatgatcc gaacgaggaa 2560081 aaaggaaagg gtctatcgct ttcaccggaa agcccttttg ctcgcactga cgatcggcgg 2560141 tattttttca ttgctgaccg ctttgaacgg acacgaatct gcacagatgc tgtacgaata 2560201 ccagcccgaa aaattagccg gtgcggaagg cctatttgaa acaagatccc acgccccgct 2560261 cgctatcggc ggttttaccg acccgaatga agaaaaagta aaatgggcaa tcgagattcc 2560321 atgggcttta agctttttgg cagcgaaccg ttttgacact gttgtaaaag gattaaatgc 2560381 atttccgaga gatgaatggc cgccgctttt cattcacacg ctgtttaatg cgatggttgg 2560441 tgtaggcatg ctgctaattc tttattccat tatcggtgtg gtctggagaa aggtgctcaa 2560501 gaaagaccgt ttcccaacgt ggcttttgat cattttcatg acagcaggcc cttttagtct 2560561 catcggcatt gaattcggct ggattttcgc atgtacgggg aggcagcctt gggtcatcta 2560621 tcatctgctg aaaacgtcag atgtcgtaac aacgactggc tcgatcgggg tgctgttctt 2560681 atttttcaca tttgtttatg ccgtgttagg cgcagctgtc gtctacgtgc tgctgtatta 2560741 tttccgcaag cacccggttg acgaagattt aaatacagcg gagtcgtaat ggctccgcaa 2560801 acaggaaacc aaatggaagg aagatcgtac aaatggagat ttcaactgac gctctgatcg 2560861 ccatctcaat tatctggggc tttgtgttta tttacgccgt catggcgaca atggattttg 2560921 gagcgggatt ttggtctatg atctatttaa acaaggagca tatgaaggcc accgatattg 2560981 cgaatcgctt tttgtccccg acttgggagg tcacaaacgt ctttattgtg gccatcgtcg 2561041 tggcgctttt cagttttttc cccggcgcga catttgtgct cggcaccgtt ttattaattc 2561101 ccggaagcat gattttgctg cttttagcaa ttcgaagcgg atttctcgtg ttttcaaata 2561161 cagcaaagga gcggaaaacg ctaagatata tttccggcat ctccggcttt atcattcctg 2561221 ctattttaat tttggtgctt cctgtgacac acggagggtt tatagaaaaa acggatggaa 2561281 tctataactt aaatatgtct aaaatctttt caagccccaa cgcctattca tttatcgggt 2561341 ttgcgatttt aagcacctta tttttgtcct cgctgttgct tgcagatttt tcaaatgtgg 2561401 cagaggaaca ggatgcgtac cgagcctaca gaaaaagcgc cctgattacc ggcccgattt 2561461 cactgttgtt tgctgtatgc attatggtaa ctatgcggaa tgaagcaaac tggctgtaca 2561521 gcggaatgat gaatgatttt tcttggatta ttgcatcgtt cattacattt gtcattgctg 2561581 gaatcgctct ttttctgcct aacaaaagct ttggtcaaaa catcggaaaa ccgcgtctcg 2561641 cacttgttgc gattgggata cagtattttc tcgcaagcta cgcgtacggg cgggcgcatc 2561701 ttccgtatat gatttatccc gatgtgacag tcatgtcagg cttcacagag ccagcaacgt 2561761 tcagagcgct gtttgcaacg tatatcgttg catttatcat tctatttccg ggcttctttt 2561821 tcttctggaa aatgtttatg cgagataaac gctatatccg ccaggaggaa tagagggcaa 2561881 gccagccggc tatactaatc cagaaccttt ataaggaggg gatggcatgg agcagaaaat 2561941 tctatgtgag gtcaacaact gttcttattg gggcaaaggt aacaaatgca ccgctgatgc 2562001 catttatgtt gtcagccata ctggtgaaac ggctgaaaac agccgggaaa cagactgcaa 2562061 aacgtttaag ccgcatgatt tataattaaa agaaagagct gcatcagcca gctctttctt 2562121 tttgcatgtt gagtgttctc agctttttag ttatgacccc gtttgcaggt gaaaacaaaa 2562181 aggcgcttgc ataacataca cctgtcatgg ccgccatcgc tcctgaaatc gaaacattaa 2562241 gccacgttgc gaagaaatag cccatgaccg ccgacagccc gccaatcaac gcgctgagaa 2562301 tcagcatata aagaagccgg tctgtcagca aatgtgccgc agccggcgga acaatcagca 2562361 tggccacaac caatacggca cccaccgaat caaaggaagc aacagtcgtc aaggacagca 2562421 tgcccatttg cacgtaatga atgagcaaaa ccggtattcc caaggctaaa gccatttgag 2562481 gatcaaacga agcgatttta aactccttat agcacacact gatcaacact acgtttaaaa 2562541 ccagaacaga tgccagcatc caaaacgctt tcggcccaat atcaaccccg aataccgtca 2562601 ccgtattcca cggcacaaaa gcgatttctc ccattaacga gtgctcaata tcgagatgga 2562661 cattcgctcc atacacagaa agcaaaataa ccccgattgc aaataaggat gtaaacacaa 2562721 ctcctatggc agcatctgat tgaaccccct tgctatgaag aagctgaacc aagaaagccg 2562781 ttaacagacc ggttgcggct gcgccaataa acatataaat cccatcgaga cttcccgtca 2562841 ctagaaaagc gccgacaatg ccaagcaaca ctgtgtgact gattgcgtcg gccagcatcg 2562901 ccatgcttct cagcacaaga aatgtgccga tcaatccgca gcttacaccg actaatacac 2562961 cggtagctat aatccatgct tcaaaactca tttgcgatct gtcccttctc ggcatcatga 2563021 gacgcttttc gacgctcagg catccgtcca tacagcttta agagtgaata aagccgctct 2563081 ctcgtttctc tcggtaaacg gtccgggtca aagtagtcct gatcggattc tatattggca 2563141 agttccattt catgcatgag atacacttca tacatccgct gcttcaaagc tgtgtgatag 2563201 cctttttcta tccctttgct tgtgatttgc caaatcccat tttcgatacg ctcaatgcac 2563261 ctctcttgtt ccaagtcatt taatgcctta aggcataatg aaggggatag gcgtcttttc 2563321 tttcttacac tttcaacagt tacacaaaga ttattctttt catactgttc ataaatcgcc 2563381 aaaagcactt gctccctgct tgttctgcgc cgcagcctca tcagccttat ggctttagca 2563441 gccaatcccc gcttaggcgc gcaaatcatt gaaaaaagaa agagcagcgt tgcagataag 2563501 atcattaatg gccctgtcgc cattcccttc atcgtggtgc taagcagggt tccggccact 2563561 ccgctgaccc cgcctgtaat cccggcaatg atgatcatcc cggttaatcg ttcggtccaa 2563621 tatctcgcgg ttatggcagg tgtaatcagc atagccgcca ttaatatcac accaacagtc 2563681 tgaagcccaa tgacgacagc acagacaatc agacaagcca aaagcccgtt taaaaaacgc 2563741 accgggattc ctaatccctt tgcaaacgcg agatcaaaag taatcaatgt aaattcctta 2563801 aagaaaacaa tacataggag cagtagaaca gcggatatcc ctgcaataag gatgatatcc 2563861 tgcctgacca atgaagcagc ctggccgaat aaaaaagaat caagcccgct ttggcttccc 2563921 gccccctgtt gctgaatata tgtcagcaga atgatcccga cgccaaaaaa cacagaaaga 2563981 acaatcccga tcgccgagtc ctcctttgtt tttgaaagcc gaggaatcag ctgaatacaa 2564041 aacgttccga gcagtccggc gagcgctgcc cccagcaaaa agaaaggcag tgatttttgc 2564101 ccggtgaaca gaaaagcgag acacactccc ggcagagctg aatgggccat cgcatcgccg 2564161 attaaacttt gctttctcag cagcacaaag ctgcccaaaa caccgcttgc cgtcccgagc 2564221 aaaagcgtac cggccagcac ccactgtgta ttcggatgct gaagctgcag ccacaaactt 2564281 tcaaacattg cgctcactcc ttatgtcctt ctgccagcac tttatctttt aaaaacgtaa 2564341 gccttcctcc atatgttttt tgcaggtttt cgatcgtaaa aacgttttcc gtcggtccga 2564401 aagcgatttt ccttaaatga agcagtaaga tccaatcgaa ataatcctcg gcggtctgca 2564461 gatcatgatg gacgacaagc acggtttttc ctttttcttt gagttctgcc aacagcgtca 2564521 taatcgcgcg ctccgtcgct gcatcaacac ctgcaaacgg ttcatccata aaataaatgt 2564581 cagcgttctg gcagagtgcc cgggcaagaa acacccgctg ctgctgtccg cctgacagct 2564641 ggctgatttg ccttttcgca taatcatgca tcccgacttt tgttaatgcg gccttcgcca 2564701 tctccacatc cgctttcttt ggcctcttta ataaaccgat tctcccgtat cttcccatta 2564761 ggacgacatc gagcgggctt gtggggaaat cccagtcaac cgagccgcgc tgcggaacat 2564821 atccgattct ggtccgctga tccttatagt ctttgccgta aatagagatg tctccggaag 2564881 ctctgggcac aagaccgaga atcgttttga tcaaggttga ttttcccgcg ccgtttgggc 2564941 cgataatgcc aataagtttt ccttcaggca cctgcagcga aatgtcctgc agtacaggct 2565001 ttttatgata agcaaccgtc acattatcaa gctcaacagg gaacatatcc tccacctctt 2565061 ttctttattt aagcgcttta gtaatcgtgt tgatattgtg gcggaacatt ccttcgtatg 2565121 tgccttcttt tgtgcccttt tcacccatgg catccgaata aagctgaccg ccgattgtga 2565181 ctgtatggcc tttttcttta gcgccttcca ccactgcatt gattgatttt tcagatacac 2565241 tgctttctac gaacacagct tttatttgtt tttctgtcag aagatcaacc agctcctgaa 2565301 catcccttaa tccatagtcc gaatctgtgc tgagtccctg caggcctttt accttaaatc 2565361 catactcatt cccaaagtac gcaaacgcat catgagcagt cacaagcaca cggcttttct 2565421 ccggaatatg tgcgatctcc ttacgcgacc acttatctaa atattgcaaa tcttctttgt 2565481 actctttggc atttttccga aaggcatctg cgtgctgagg cattgctttg ctgaattgcg 2565541 cttcaatttc atccaccgca tagatccata acggaatgct gaaccagacg tggggatcaa 2565601 acgtcttgcc ttcccccgcg ggaataagct tatttttcgg aatggcctca gctactgccg 2565661 ccgattgttt ttgttcgccg attttttgga ggacatcctc cattttccct tccaaatgca 2565721 acccgctgta cagaacaaca tcggcagaca ttaatttttt cgtgtcacct tgggaagctt 2565781 tgtaaaggtg cggatcaacc cccggtccca ttaaagaggt gacttttacg tgcttacctc 2565841 cgatgttttc tgctgcatcg gcaatttgag atgttgtcgc tgtcacttgt aattgctgat 2565901 cagcgctttt tccggctgaa tccgttccgc atcccgttaa agcaaaggtc gcaaaaagta 2565961 ctgctgccat cagcccttgt ctcatatttc tcctcctctt tgccatcaat gtccgattgt 2566021 tttatcttat gttgtcagtt cttagacatg tgacattaaa ttagccaaaa gcatgtttta 2566081 tttacacagg acaaaaagtt tccctcatgc aaaattatcg cgtttggcca tttttgtcaa 2566141 gctgatttac ataaaaaaac cggctgggtc agcagccggt ccaaacgaga agggatgtat 2566201 tcaacgaaca cttttactgt aacagcacag tgtcatttat tcaaaatagc aaaatgcttt 2566261 tttcttaacc atgctgtgtg aaaacatcca ttttggtcac atattttcgc ataatatctt 2566321 ggtttacctc aacccctaaa ccaggctgtt ttgacacaga aataaatcca ttatcaatac 2566381 gaatatcagg agttacaata tcttcatccc aatagcgtga ggatgaagat atatcgccag 2566441 gtattgtgaa ttgaggcagt gaagcaagcg ccacgttctg cgctcttgat atgcctgttt 2566501 ccagcattcc tccgcaccaa acctgcatat gatgctcttt gcataaatca tgaattttta 2566561 aggcttctgt taagccgccg acacgagaag gttttatatt aataattttg cagcttccta 2566621 gctcaatcgc ccgtctcgca tcatcaactg aacaaatgct ctcatcaagg caaatggccg 2566681 ttttcaaatg tttctgcaag tggcggtggt caacgatatc gtcagcttgg agcggctgct 2566741 caatcatcat taaatgatag tcatcaagct cctttaaacg gctgatatcc ttcagttcgt 2566801 aagaggaatt ggcatcggcc ataagcggga tggttgggaa tcggctgcgg atggccttga 2566861 ccaattccac atcctgccca ggctgaattt taatttttat tctttgataa ccttcttttt 2566921 gatagctctc aatttccttc agcatatcgt caagaggcgc caggccgact accaccccgg 2566981 cagggacttt atctcttgtt ccgcccaatg cctcagcaag ggatacgccc ttctttttgg 2567041 cataaatatc ccatacagcc gattcaagtc ccgcttttgc catccggttt cctttatacc 2567101 gcgccaggct gtccggcact tctgaagggt gattgaattc acggccgacg acatttggga 2567161 taaaaaaatc ttttagcata tgcaaacatg ttccaatggt ttcctcggtg taccaaggcg 2567221 aagagaaagc ggaaacttct ccccagcctg tgacacctga tgtatcaatg gcttccacga 2567281 tcagaaattt acgctcttga agcgtttcga tactgttttt aaacggtttc tttaagttca 2567341 tgctcaaatg gtaaagcgtg attttttcta tttcgatcat agcagttctc ctttacgcgc 2567401 atccttcagc tgatttcgca agagcttatt agacgcattg cgcggcaggc ggtcaagcac 2567461 aaagaatttt gccggaattt tatacttcgc caagcgttct ttgcagtagt cagtcaattc 2567521 tcctgcgctc acaggcttgt gaaggacaag ataggcgtga ggcactttcc cccatttttt 2567581 gtcctcagcc cctgaaaccc cggcttcggc cacagcgggg tgtgaaagca gcactgactc 2567641 cacttcggcc ggataaatgt tttctccgcc ggatatgatc agatctgaac gtctgtctaa 2567701 tacatataaa aagccttcat tgtccaaata accaagatca cctgttttca gccagccatt 2567761 ttgaaaggag gcttcgtttg cgctctcccg gttaaaatag cttttcatga cattcgggcc 2567821 tttgaccatg atttcaccgt gttcatacgg ttcacatacc tgtccgtccc gctctatttt 2567881 gatttcacac gaaaacagcg gtttccccgc agatccgagc ttttccatgc tgaattccgg 2567941 cgacagggta acaatttgcg agcatgtttc tgtcattcca tatgactgaa agacagggaa 2568001 tcctttctca cggcattcct caagcaatgg cagcggtgca ggaccgccgc cgagaagaat 2568061 gcatctgatg gattcagggc agcggtttgt ttcttccaaa agactggcca gcatagtctg 2568121 caccgcagat atcattgtca cttcatgcct gttgatagaa tgcagcacat cgcttacgga 2568181 aaaacgctgg tgaagcacga cagtcattcc atagatcaca gatttaaata atgcggacaa 2568241 tccgctgata tgaaagagcg gcaatgcgat aagccagcgg tcttgttctg ttatacccaa 2568301 attaagagcg gacgacaccg cactgaaata atggtttccg aacgtttgct gaactccctt 2568361 gggctttcct gtcgtacccg acgtatacat cagcgttgcc gttgcatcca tttgcatata 2568421 agcctcgatc tcaatttcct ctgctgcttc tttcatcagt tcatccacat caatcgtttg 2568481 aacgatgtgt tcatattctt tcttctcaaa gcttgaatct gtcaataaaa agccggatcc 2568541 cgaatcctcc agctgaaaca gcctttcatg tgttgacagc ttcgtattca aaagcaccgc 2568601 cttaacacca agcaaaaaac aagcgtgaac agcgtatacc atttctgcac ggttttggag 2568661 caaaatagct gcagtatccc ctttccgaac cgaatgagcg gcaagctgtt ccgccattcg 2568721 tttagacgcg gcaaacaatt ctgcaaatgt cacggtttgg tcttcataga tgagagcgat 2568781 tctctcaggt gtcagctgtg cccgctgcat gagccagttg ggctgttctg tcagcatgtc 2568841 atcatctccg aggtaaaatg tctgtattga aaagaaaaca gcttggaccg caaagtctca 2568901 agctgttggt ttactagata ttgctgatca cggaaaacga gggaactgtc cgaaatcagg 2568961 tttgcgtttt tccttaaagg aatcacggcc ttcttttgct tcatctgttg tgtagtaaag 2569021 aagggtagca tcccctgcaa actgctgaat tccagcaagt ccgtctgtgt ccgcgttaaa 2569081 cgcagcttta agaaagcgca gtgcggtcgg gcttttttca agcatttctt cacaccattt 2569141 aatcgtttct tcttcaagct gttccaaagg aacgactgtg ttgacaagac ccatgtccag 2569201 tgcttcctgt gcgttgtact gacggcatag gtaccagatt tcacgtgctt ttttatgtcc 2569261 tacaattcga gccaggtagc cagaaccgta acctgcatcg aagcttccca ctttagggcc 2569321 tgtttgtcca aaaattgcgt tgtccgcagc aattgtcaag tcacatacga tgtgaagcac 2569381 atggcctccg ccgatcgcat atccggacac catcgcaaca accggtttcg ggatgacgcg 2569441 gattaaacgc tgaagatcca atacgttaag acgagggatc tggtcgtctc ctacatatcc 2569501 accgtggccg cgcacttttt ggtctccgcc agaacaaaat gctttgtccc ctgcaccggc 2569561 aagcacgata accccaacgt tttggtcgtc tcttgcgtca gcaaacgcat caatcatttc 2569621 agcaaccgtt ttaggggtaa acgcattatg tacctcaggt cggttgattg ttatttttgc 2569681 aatgccatta tacgtttcat acaatatctc atcgtatgtc cgttttgttt tccattcagc 2569741 catatgatga cctcctttta ttctctatgt gaatgagtca gatgcttgtc aaaaactcac 2569801 tcactatttt accaaacaat cgcggctgct ccacatggac cgtatgtcct gcttttggaa 2569861 caatctctat tctactagaa ggaagcatct tatgcacctc ttgattgatg gcgcaaaatt 2569921 tttcgtccca ctccccgcag atcagaagca caggaacatc tatttcctct acacggctcc 2569981 acaaggaagg ctgtgaaccg gtgcccatgc cggttaaact gttcgcaagc ccaatcttat 2570041 tgttccgcag acggcccgat cgtatcctgt accgaatatc ttcagccagc ctctgctgag 2570101 atgaaaacaa agggatattc tcccaatacg caacaaacgc ttcgagcccg tctcgtaaaa 2570161 taaaatcagc aagcttccgg tcccgcatga ttcgttcccg ccgttcccca agtgttttga 2570221 gccccggcgt cgtgctttca agcacaagtg ccgatacccg ctcgggatat gtcatcgcaa 2570281 aagagtaagc aagccttcct cccatagaat acccaatcaa tttcactttg tgaagtttta 2570341 attgatcaaa aatctcggca aggtcagaaa cttgccgggt tgtgctgtat cttttcccat 2570401 tcagcggggc atcggtttcc ccatgcccta aacaatcaat tttgatcaaa cgggaatcag 2570461 gcagcatttc atcaagaaaa gtccatgatt gtttgctgcc ggtaaaccca tgcagacaga 2570521 cgacggcttc ggaagcattc ggtccctcgt ctgccactgc atatcggaca ccatctgata 2570581 ccgttatgtt tacagttccc attgtttttt cacttcccgc acagcctcat tcagcatatc 2570641 gcgatgaagc tggactcttg attggcgatc cgttttgatt tcaatcaaat ggagtccggg 2570701 cttgtctgcc tgcggcgcgt aagctgtttt gaattcatcc caagaagccg ggcatgaata 2570761 cgttccgccg taaagtgcag ccgcatgctt gaaatcgagc cctgtcggtg tgccgaacaa 2570821 atcttcaaag tgtgtcttct cagaagcctg cggcaaaaag gagaaaatcc ctcctccgtc 2570881 attattgaca agaatcacag taagaggaat acccagcttt ttggccgcca gcaggccgtt 2570941 taaatcatga taaaaagata aatctccaat cacaagggta acaggcgctt ttgttccttc 2571001 acataccccc atggcagagg agacgacacc gtctatcccg tttgctcccc ggtttgaata 2571061 aatccggaaa gggcggtcct gcttttcaaa aaacgtatca acatccctga tcggcatgct 2571121 gtttcccaca aacagcgagc tgttttcagg cacaagatgc tgaaggattc gatagagatt 2571181 gccttcaaac gaaacatctt cactgctgat tgtttgcaga tgctcgcgga accgcccatt 2571241 gacaaactgc cacttttcca gccactctga ggatctggtg gcagcagtaa ggcctgccat 2571301 gatctcctca gcaaaaacag acgcattaca atgaatcata tgcgcgcttg cctgtgtcgg 2571361 gtctctccac cctccatcct cgtcaatcac gatttgctga atcgtcggat catccttaag 2571421 ccataagaaa accggttttg aaacaggcat cggtccaaac cgaatgacaa catcaggacg 2571481 gagtttccgc ttcagctcat catcttttaa aaacgaatca tacgcatcaa taacagtgct 2571541 tttatcatga acaccattcc gcagattaga cagcggatct gctaaaattg gatactgaag 2571601 cgcttttgac agcgcaataa tgttttcctt gtccgcatca ctatggagct ctccgcagac 2571661 gatcattcct ttttcagcct ctgcgagcat ctcagccaca tcagacaggg actctcggtc 2571721 aacagactgc gtacccgttt tcacagacac atgacggcct gttctcattc ttccaaacgg 2571781 ctcatctgaa agatccggca tcagcggttc gcgcagcggc acattcacat ggacaggccc 2571841 catcgggcgc ttttgtgctt ctccggcagc gcggcttgcc agcgttcgga tgtatctcag 2571901 catttgcgga gactcttcag gaagagcaga gtctgtgaaa aacttaacaa agttaccgaa 2571961 taagaagtgc tgattaatag cctgcggtgc gcctacttcg cgcagctcat gaggccgatc 2572021 agcagttaac acaataatag gcacccttga ataatgggct tcaaccacag ccggataaaa 2572081 gttggccgcg gctgttccag atgtacagat caatagtacg ggacgctgct tcgcttttgc 2572141 caaacctaat gcaaaaaatc cggcagacct ttcatcaatt tggacatgga cgctgatatc 2572201 gggatgcgca gcacaaagaa cagccagcgg tgtagatctt gagcccggac aaacgacggc 2572261 gtccgtaatt ccggaaaggg cgaattcatc aataaaactt ccgatgtaat gagtaatcgg 2572321 gttgactgtc aacgcctctc acctcctaat gcagagatca tcggcttcaa tttaatctgt 2572381 gtttcttcat attccgagat tggttccgag tcttccacaa taccgcaccc ggcaaacagc 2572441 cttgctgtgc ttccttcgat gagccctgaa cgaatggcga ccgcgaattc cccgttatcc 2572501 tggctgtcaa tccagccgat aggggccgca taccagccgc gggacatcgg ttcaatctcc 2572561 ctgatcacgt caacagcttt ttcctgaggt gatcccccaa gcgcgggagt ggggtgcagc 2572621 ttctcaatta agtcaaaaat cgaagcagac tcgcgcagct gtccgacaat cggcgtaaac 2572681 aggtgctgaa cgctttttgt tttgtacaaa acaggtccat caggcttttc aacctctgaa 2572741 cagcttgata caaaagcatt atgaatcata cctaccacaa tatcatgctc aagcaggttt 2572801 ttctcatcgt ttaataattc aaggcctatc cggcggtcgt cttcttcatt cacgcctcgt 2572861 ttaatggagc ctgccagaca ggaagacatg acagtgccgc cgtctctttt gatcagtctt 2572921 tccggagacg cgccgacaaa ggttttgcct tcttgttcaa ttgcaaaaac atagcttgtc 2572981 tgctgatcgt ccagaagcgt tttaagcacc ggttcaattt ggattggacc gtcaaacgtg 2573041 agcagcagct ctcgggcaag aacaacctta tcatattgtt tctctttaat ttggcttgtg 2573101 gccgtttcga ttgctttcag ccaatcatcc ttatccagct cttcggctgc tgcaatcaca 2573161 gcctgatctt cttgcttgaa atcgggaacc ataaattccg ccgcaaaagc ttttaagcct 2573221 tctaaaacag cttctgcgtc ttctcctccg cttacccatc tgttaactgt taagaacggg 2573281 ccttcagcag tcatcgtcag cataagcgca ggcacaaaga aatccccttc cgagaaatgg 2573341 tcccattgtg aacctctttc ttcgcaaggg tcaaaagaaa atcctccgaa taacacaggt 2573401 cccactgcag aatgctgcag cttttcttct tcataaatat gaaaagccgt ctttttaaag 2573461 cgctcccatt gttcaaaaac ctcacgatac cgctcgctgt ttttttgatt tgtctggaaa 2573521 accgcttctt tgccaagacc gactattgtc aattcacttt caggatctga ccaaaaaaat 2573581 cgattgcctg tatatttttt tgctccgtaa ttgaaaaatg atagagggtc aagagactcg 2573641 atttgtctcg aatagcttat taagacagca tggttgactt ctttggcttt atgtaatgca 2573701 tgtagaactt cctttcggaa cgtacgctgc accgttgtca ccatgagaca ttcctccata 2573761 atccttaaaa tgcttttaat accatacacc tgtgtctcct ttgtgtcaaa cacagatcat 2573821 gcagtccaaa tggcctgcct tacctattat aaacctaatt tcagaaatga aaaagaaaca 2573881 aagcttaaat ttctttctcc actgatagca aaggttgtat ccgcttacca taaaaggaaa 2573941 acctcctata ttcctccacc cgccatttat gaaagttctc aggcgatctg ttcatactaa 2574001 aggtatgcat cacagagaaa cgaggcgatc acattgctta cgaaagaaca gcttcagcat 2574061 ttaaaaaatg aactggaaca aacgaaaaaa gatatcttaa accgtttcaa agacaatgat 2574121 cattttcagc ttaactcagc ctttccttat gattcgtggg gtgagctttc ggcatacgac 2574181 aaccatcccg gcgatcaggc gacagaactt tacgagcgtg agaaagacat cgctctagac 2574241 ttgcatgaga gagagcacct tcgggacatt gagcattcat tgaaggcgat agaaaacggt 2574301 acgtatggca tttgtgaagt cagcggaaag gaaatccctt tcgaacgact tgaagcgctt 2574361 ccgactgcca caaccctcgc ggagtattcg tcacaggacg tggtttccaa agaccgtccg 2574421 attgaagaag aaacaccatt cgggcaattt gaatttgatg atgatgaaga aatcagagcg 2574481 ccatatgaca gtgaggattc ctatcaggat gtcgaaaaat atgggaactc acaaacgccg 2574541 caggatatgg aaaaccctcc gctcagctat gatgatatga cgatgaatgc cgaagagaat 2574601 atcggcaata cggagtctta cgaaaatttc atcgctacag atatcactgg gaaagaaatt 2574661 accgtttatc aaagcagagc ccatgagcgc tatgaagaag aacttgacga agagggaatc 2574721 atgaccacat tcggcgatct ccacgctgat tgaaccccca attattgggg gttcttttcc 2574781 gttttcagca tatcgtaaat cagcttcaga taatcctttt gcaggccgat gtcataccgc 2574841 tcgccctcta gcaatttccc gtatacggta catgccccga gcgaagcttt tatcgcatcc 2574901 gttacctgca cttctcctcc gctatcagct tctaatgcct ccagctcatt aaaaatatcc 2574961 ggtgtgaaaa tataacgccc tgctgcggca aaatgagacg gagggttttg tttaggcttt 2575021 tccacaatat cctgtatgcg ataaagccct ttttcaacag gctccccttt tatcaccccg 2575081 taatgatgta aatcctccgt ttttgtttct tttaagccga tcacactgga ctgatatttc 2575141 gtatacgctt caatcagctg ccccaaagcc ggctgattgg cggaaaaaat cagatcatct 2575201 ggcaaaacga cggcaaaagg ctctcctcct gcaaattgct ttccgaaaga aatggcgtcg 2575261 ccaagaccct ttgcataagg ctgccgcaca tagtgaatcc gtatatccgg aatgggatgc 2575321 tctctaagta aatgcagttt attcttagag gccaaaaaag cctcaagtgc caaagaggaa 2575381 tcaaaatagt cgacaatcag atttttatgg ctcgatacaa ccatcaaaat gtcctcaatg 2575441 cctgactcct ttaattcttc aacaagataa tgaatcacag gcttagatcc taccggaaac 2575501 atttctttcg gaatcacctt cgtcaccggc agatttctcg tgccgaatcc gcctgcagga 2575561 atgatcgctt tttttatcat ggtattttcc cctcagctca tgtttattac atgatattcc 2575621 aagagcgcat cccgatgttt gtacatctga aattaggcgg aagcaactgg gcagaaagcg 2575681 gaatcacgaa ccagcccttt tttaatagga tattgatata tgaccagtaa tcttgtaaag 2575741 gagctcaggt gatgaaaatt tgtgtggttg gcgccgggta tgtcggttta accctatcag 2575801 cggcactggc atccatcgga catgacatga tatgcacaga caaagacgtc aaaaaaatcg 2575861 ggcagctgaa aaaaggagtc attccctttt acgagcctgg gctttcagat gcaatacttc 2575921 gttgcggcaa tctctcgttt tcttctgaag tgaaatcgag catggaggaa tgtcccgtta 2575981 tttttatcgc agtcggaact ccgccgcgtt cggacggatc agctgatacg aaagccctgc 2576041 agtccgtcat cggtgattta agcgaggcga tccgatcgta taaaaccatt attacgaaaa 2576101 gcactgttcc gcccgggaca aatgaaaaca tagcaaaaca gctgattgcc tccggagtgt 2576161 ctaaaaacct ctttaatatc gtatccaatc cggagtttct gcgggaaggc aatgccttat 2576221 atgacatgct gcatcctgac aaaacagtca tcggtgttca ggaagaagat cacgtatcgg 2576281 cagccatcgt caaatccatt tacaaacaca ttgatacccc ttttatcgtt acaagcttag 2576341 cgggagcaga gctgatcaaa tatgccaaca atttcttttt agcggccaaa atttcgttca 2576401 ttaacgaaat ggcccgcata tgtgaagcct atcaatcaga tatctcagat atttcccgcg 2576461 ctatcggtct agacccaagg atcgggaagc actttttgca ggcaggcatc ggatacggag 2576521 gctcttgttt tccaaaggat ctgcaggcgc tgcaatttgc tgcccaggaa aaaaacacgg 2576581 agaccttcct gctccgggcc gtgcagcaca ttaatgacac ccagcttggc ctgtatatca 2576641 aaaaaataca gtcattcttc gaaacacttc aaggcaagaa agcggctgta ctcggcattt 2576701 ccttcaaacc gaatactgat gacatccgga attctcaggc tgtcagactg atggaaaggc 2576761 tggcggagct gggatgtgat gttcatgcat atgatcctga agctgtactt ccagaacatt 2576821 tgcggcaaca tgtaactcag cattctcaag cttttgatgc gatcgaagag agtgactttt 2576881 tatttttggc gacagaatgg tctgagtttt tagcgtttga ttggaaaaag gctgcagata 2576941 tcatgaaagg gcgtcttgtg attgacggac gcaacgtact aaaaaaagaa ctgatcgagg 2577001 cttgcggcct gatctgtacg ggagttggcc gtccatgaaa atactcgtca caggagcagc 2577061 gggctttatc ggctcccacc tctgcgaaga attactaaaa gataagaaac ataacgttat 2577121 cggaatcgat gactttatcg gtcctactcc attttccttg aaattaaaaa accttaaaaa 2577181 cctgctgccg gaaaagcgat ttacgttcat aaaggaaaat ctgctgacag ccgatcttgc 2577241 ttccttactg gaaggagtgg acgtcatctt tcatttggcg gccataccgg gtgtccgctc 2577301 aagctggggc aatcattttc acccatatgc cgcacataat atccaagcgc tccaaaggct 2577361 cctcgaggcg tgccgggaac attctattca aacgttcgtc tttgcatcca cctcttccgt 2577421 ctatggcgaa aaacaaggaa aagtcagcga aaacacgtcg ctttctcctt tatctccgta 2577481 cggggtaaca aagcttacgg gagaaaagct ttgccatgtg tataaacaga gctttggcat 2577541 tccaattgtg attctccgtt tttttaccgt atacgggcca agacagcggc cggatatggc 2577601 ttttcaccgg ctcattaagc agcaccttca gcaaaagccg cttaccatct tcggtgatgg 2577661 gcagcagtca agagatttca cttatatcag cgactgtgtc aaaggcatca ccgctgttct 2577721 tgggaaaccc caccttattg gtgaaacagt aaatatcggc ggcgcagagc gtgcctcagt 2577781 cttaaaagtt gtctccctca ttgaggatat ttccgggaga aaagcaacac tgcacttttc 2577841 ggacaaaata gcaggggaac cgagcaacac gtgggcggat atttcaaaag caaaacagct 2577901 cttgcattat gatcccgcca catccttaaa ggatggcttg accaacgaaa tcgcctattt 2577961 atcgtcgctg tatcaggggg aataaaaatg aagcttgcct ttatctgtac agaaaagctg 2578021 ccggcgcccg cagtacgcgg cggcgctatt caaatgatga ttgacggtgt cacgccctat 2578081 ttcagcagca ggtacgacct gaccattttt tcaatagaag atccatcgct cccaaaaaga 2578141 gaaacaaaag acggcgtaca ttatatccat ctgccaaaag aacattaccg cgaggcggta 2578201 gccgaagagc tgcgagcctc ttcctttgac ctcattcatg tgttcaacag gcctttaaat 2578261 gtctctttat ataaaaaagc ctcaccaaac agcaagatcg ttctgagcct gcataacgaa 2578321 atgttttctg aaaaaaagat gaccttcgcg caaggaaaag aagtactcga caatgtctcc 2578381 atgatcacaa cagtgagcga atttattaaa caaaccgtca ttgaacgttt ccctgaagcc 2578441 gaggacatca caaaagttgt gtattccggc gttgatttaa actcttatcc gcccgtctgg 2578501 acgatgaaag gctcggctgt cagaaaaaca taccggaaaa aatacggtat tgaagataaa 2578561 aaagttattt tattcgccgg ccgcttaagc ccgacaaaag ggcctcacct tctcattcac 2578621 agcatgagac ggattttgca gcagcaccct gatgctgtac tggtcatagc aggcgggaag 2578681 tggttcagcg atgacagcga aaaccaatat gtcacctatc tgcgcacgct ggcgctgcca 2578741 tacagagacc acataatctt tacaaaattc attcccgcag acgatatccc aaaccttttt 2578801 ctgatggcag atgtatttgt gtgcagctct cagtggaacg aacccctcgc ccgtgtgaat 2578861 tatgaagcaa tggcggccgg cacgccctta attaccacaa accggggcgg aaacggtgaa 2578921 gtcgtaaaac acgaagtcac cggccttgtc atcgatagct acaacaaacc ttcttcattt 2578981 gcaaaagcaa ttgacagagc ctttacagat caagaattaa tgaacaaaat gacaaaaaac 2579041 gcccgaaagc atgtagaagc tttatttacc tttacccatg ctgccaaaag gctcaatact 2579101 gtttaccaat ccgttctgac cccgaaaaac aaacaatttc cgccgccttt tctgacgcaa 2579161 aattttgatt tatcatctat caatcagctt tttgtgaaag caaaaacata aaacctacag 2579221 ctcgtgttgc aaaacgggct gttttttcgc tacagagaac ttaaaaaaag gcataaatgt 2579281 gactttatgc cttgcgcttt acagtttgag aaaaccatgg agctggttta gattcacttg 2579341 gaagaatgat gatttccact ttagcttctt ccgctaagtc tggttcttca tcttcatcct 2579401 cttcttcata tgggggcgct gagcgtttcg aatcacgctc ctcctcaggc tccagagtgg 2579461 tttcgaattt tgtttcttct tcatcatcga cgattttgcg atctgtttcc ttttccttcg 2579521 tttctttttg atattctttc ggtgcattga tgtgagggag ctctcgaatg ctgcccacat 2579581 ctaaatgctt ctcctcttct tccttctcag ctgagattga gtcatgagcc tgccatccca 2579641 tcggtccagg cggtgtaaat acgaattggt cgagatccag tttagaaata gaggcttttt 2579701 gtctcgatga cctcatgtca attcgcctcc cgatacgctt ttatcttttt atacagttcc 2579761 ggcagtttat ccaaaaacga atctttagat tcttcaacag aaatcatgtt ttgcagcgcc 2579821 cagttatact tctcatctga ccacgttttc ttttgcttca aataatattt gtgcccgatt 2579881 gcacagaaca aatgcggaaa cgcgagatca atccaaagta cctcgtactg tttttctgtg 2579941 agcggataca ctgcgtcgta ggccgcaagc agtgcaacca tgaaatcagt atcccataca 2580001 gaaagcttaa ccatcacttt attcagcaga atacgaaggt ctcttgacgg caaatcgtag 2580061 gtaatcgagt gaagctcctt taaaaaaggc tccccttcga tctcagtcaa acgtgccaat 2580121 gtaaaatcct gaaaacagaa tccgccatgc tcgagtgtct cttttgtcca ggtttcgtat 2580181 tctgagtcat caagcgctct gagagcttct tttcctcttg ccagcatttt atcagcatgt 2580241 tttaagaaag tttgcgaaaa tacgtcatca ggataggatg ctgcgatctg catattccct 2580301 tcaagttcct gcagcttcca acggtacaat ttgtgccatt ttcccagcct gcttctcttc 2580361 ttgctttcat ctgtgcaaac atatcctttt gaggcatgat gaaaatggcc ggcaaatgac 2580421 atgacttttt tcatttgctc tgcatcatag taaatcattt cttttcctgt cactttgtca 2580481 tataaactgt aagaaacctg atccgtgccc aagcagctac cgccattttt tgtttgatga 2580541 atcggcgcta tcggcagccc tttctcttgt aaatgggcgt gtgcctgagt gataaaaagc 2580601 atccgctccg gtttcatttg cgcttctttt agcagctttg ggccatgatc agtttcgact 2580661 tcccagattt tgcgcccgct tttgttcgat ttcagcgcca catggtcgat atgaaacgga 2580721 taataactga gaatttcgga cacaatctgt tcttcatgct ctttttggta cactctgttc 2580781 accccttcta tctgttcttt tcatagacgc tgagcagatt ttcagccacc ctctgccagc 2580841 caaaattgct ttctgcctca cggcggctgt atttcccaag ccgttcccgc ttttccgagc 2580901 tgctcagcaa atcattgata cgttcggcat attgtttagg attttcaaag tcatgaatga 2580961 tgtagccgtt tttcccttcc tctatgacct ctggattgcc tccccgattg cttgtaataa 2581021 taggaagtcc cgcagccatc gcttcataat gcacccttgc taaaggctcc tgccattgcg 2581081 aagagcatac aaatacatct gacatggtat aaaggcgcgg aatgtccttt ggcttcacaa 2581141 attgaataaa tgtgacatga tccttttgca tcgcaccaag ggtatgaaga tgtttgacat 2581201 agttatttaa ttcattatct ccgaaccatt ttgacccgat aaacaccatc atgacatcgg 2581261 ggtgctcctc aatgatgtcc ggcaaagcct gcaataatat gtgcgggcct ttgactttgc 2581321 taagccggcc gacaaacaag acgatttttt tgccgtgaag ccccagctcg cttcgcatct 2581381 cttcgcgagc tcgctgccct tcattcgtcc agcgagggtg gtacgttttt aaatccacac 2581441 cagaatacac cgtttttgtt tttgatcgtg ctgacggaaa acggcttgtg atcgtctgtc 2581501 cgatataatc gctgaccgta acaatctgcg ctacggagtc gatgcaaatc tcgccttccg 2581561 cctggctgat tttatcgtaa gcgaacattt cattgtgaac gcttaaaata aaaacagcat 2581621 ccggcgcctg tttcttcaat ttcggaaccc agcttgggcg attacaaaca tgcacaagat 2581681 caaaacggct ctttttcagc tctgctccaa cggcttcttc ataacggtct tcatccaaat 2581741 gcacataatg gacaccgtct accttctctc tatcagcgag attcggatct ttaatagaaa 2581801 acacagtcac ctcatgtttt tttgcaatta aaggggcaac cgcttcgagg tagatttgaa 2581861 tggcgcctcc tcgaaccgat gggacaggaa gcttctctgt ggcgatcagt gctattttca 2581921 tacatagcct ccattcctgc atgattttta actagttaga atcatgatac ggctgaacaa 2581981 ccaacttgtg cggaatggga ctgccctaaa aacaaaacgg gtaaacaacc agattcatct 2582041 attaaatata gtcaaataac tcaatcattt tttccttttg attcataagg taggagtaaa 2582101 acaggtaagg atgtgtcctt taatggcaga aaaccatgaa gtcattgagg aggggaattc 2582161 atcagagctt cctttatcag cagaagatgc aaaaaaatta acggagctgg ctgaaaatgt 2582221 gcttcaagga tgggatgtgc aggctgaaaa aatagacgtc attcagggaa accagatggc 2582281 gcttgtctgg aaggtccaca cagactccgg cgcggtttgt ctaaaacgaa tacacaggcc 2582341 agaaaagaaa gcgttgtttt ccattttcgc gcaggactat ttagcaaaaa aaggcatgaa 2582401 tgttcctggc atactcccaa acaaaaaagg cagcctatat tctaagcacg gctcatttct 2582461 atttgtcgta tatgactgga tcgaaggaag accgtttgag ctgactgtaa agcaggactt 2582521 ggagtttatc atgaaaggcc ttgctgattt tcatacagct tccgtcggat atcagccgcc 2582581 aaatggcgtt cccatattta ccaaattagg tcgctggccg aatcactaca cgaaacgatg 2582641 caaacagatg gaaacgtgga agctgatggc ggaggcggaa aaagaagatc ctttctcaca 2582701 gctttatctt caggagatag atggctttat tgaagacggg ctgcgcatca aagaccggct 2582761 tttgcaatcg acctatgttc catggactga acagctgaaa aaaagcccta acctttgcca 2582821 ccaggattac ggaaccggga atacactctt aggagaaaat gaacagattt gggtcatcga 2582881 cttagatacc gtatcatttg atctgcctat tcgcgatttg cgcaaaatga ttattccgct 2582941 tttggatacg acgggtgttt gggatgacga aacatttaat gtcatgctga acgcatacga 2583001 atccagagcc ccattaactg aagaacaaaa acaagtcatg tttattgata tgctgtttcc 2583061 ttacgagctt tacgatgtca ttcgcgaaaa atacgtccgc aagtctgctt taccgaagga 2583121 agaattagaa tcagcttttg aatatgaacg cattaaagca aacgcattgc ggcagcttat 2583181 ttaagaccat catttccccc gcatatcggg ggtttgatat ttataagata aagggtaatt 2583241 aaatacatgc ggaggttgca aatatgaaaa agattgtcgg cgctttagcc gtttttgtga 2583301 ttacatatgc gctgttttca gccgcaggct acctgtttcc tgtggaccaa gaatggtaca 2583361 attcattgaa aaaaccggac tggacgccaa gcggaactgc gatcggcatc atttgggcca 2583421 tcctgtttgc cctgatctcc ctttcagcag ccattgtata tgctgcgttt tcatttaaag 2583481 gtgcgaaaag cttttggttt acacttttga taaattacgt gctcaatcaa gccttcagct 2583541 atttccagtt tacgcaaaaa aatctgctgg ctgcatcgct tgactgcctg cttgtcgcca 2583601 tcacagcaat cgtattactg atcattgcca aaaaatacag cagagccgca agctatcttc 2583661 ttttgcctta ttttttatgg agtgcatttg cgacgttctt atcctttaca atcaattcaa 2583721 tgaatctgtg aacaaaaaaa gccgcttata cagcggcttt ttcacatcat cggcttgatg 2583781 ccccaaatgt ccttcgcata ttcccggatc gtgcggtcgc tggagaaata tccagaatga 2583841 gcaatgttta caatcgaatg ctcagaccat ttccttcgct ctcgataatc agcttgaatt 2583901 cgctcctgtg catctgcata tgagctgaaa tccttcagca caaaatactc atcattatgc 2583961 ggaagcagcg agtcaaagat cgattcaaat tcatctgcct ctccttcaaa aaaaccattg 2584021 atcaactgat ccgctacctg cctgattctc ctgtcatgct gataatattc cctcgaccta 2584081 tagccgccgt tttcctgata cgatagaacc tcatccgcct ttaagccgaa cgtgtaaata 2584141 cagtcagggc ccacccgctc aaggatctcg atatttgcgc cgtcatgcgt gccgatcgtc 2584201 aaagccccgt tcatcataaa cttcatattc cctgtaccag acgcttcctt gcttgcggtt 2584261 gaaatttgct cacttacgtc tgatgccgga aaaattcgct cagccataga aactctataa 2584321 ttttctaaaa aaacaacttt gatcagctgt ttgaccgccg gatcataatt gactttttct 2584381 gcgacagaat ggatcagctt aatgattttc ttggcataat aatagcttgg tgaagccttt 2584441 gccccgaaaa taaaggtttg cgggtagatt gaaaaccccg aatcctcctt gaggcggtta 2584501 tacaaataca taatgtgaag aacattcagc agctgccgtt tatatgcatg aagccgtttc 2584561 acctgtacgt cgaatatgct ctcagggttc acaaccaccc cggccgtgca aaaaatcaaa 2584621 tcggcaagct cttgtttttt cttgcttttg ttgttttgaa actgttcaat aaatgcagga 2584681 tcagtggcgt acggttctaa acggatcagt gattccggct gcttgaccca ttcatcgccg 2584741 atcgcctctg taatgatggc agacaagcct ggattcgctt ttaacagcca gcgcctgtgg 2584801 gcaattccat tcgtcttatt gttaaaacga ttcggaaaca gcaagtgaaa gtcgcgcatc 2584861 tccctttcct ttaatatatc ggaatgtatt tttgcaacgc catttacact gtagctgcct 2584921 actatggcca gatgagccat tttgacaaca ccatgcgctg taatcgccat gttctctatc 2584981 cttttccagt ctccaggata cttttcccaa actgcacggc aaaacctctc attgatctct 2585041 tcaataatca tgtacattcg cgggagcagc ggcttaaaca aatgaatcgg ccatttctcg 2585101 agcgcttctg acaatgttgt atgatttgta taagaaatcg tatgtacagt gatatgccaa 2585161 gcttcttccc agctcatgtt ctcttcatcg agcaaaatcc gcattagctc aggcaccgca 2585221 agcgcagggt gagtgtcatt aatatgaatg ctcacttttt tatgcaggcc ggataaagat 2585281 ttatgtgttt tacggtaatt gttcacaatg ctttttaagc ttgcgcatac taaaaaatac 2585341 tgctgcttca gccgtaaaat tttcccctca tcatgggtgt catcgggata taagaattca 2585401 gaaaccgctt ctgtttctcg cttataagac aaaatattac cgccgtgata atgggcatag 2585461 ggctcggcgt tccaaagcct taacgtgttg acagtgcccg tttcatagcc gatgatcggg 2585521 atatcataag gaacagcggt aacaattgtc gcttgttcat ggcgaaaatg caggcgcccg 2585581 cttttttctg tcatatggac ttcgccccaa aacggcacgt ccactgcttg atccgcattc 2585641 cttacttccc atacgttccc gtttttcagc cattgctcag gcagctccac ctgatgtccg 2585701 tctacaattt tttgctcaaa caaaccatgc ttataacgta tgcccatgcc gtgcccaggc 2585761 aggttcaacg aagcaagcga atctaaaaag caagcggcca agcgcccaag tccgccattg 2585821 ccgagacctg catcgttctc tatctgaagg atctcctcta aattgatgcc gatttccttt 2585881 aaaccagctt ctacaacatc acgaacacca agattcatta agttttgctc aaggagctga 2585941 ccgagcagaa attcgattga taaataatat gtctgcttcc cggaatttga tctgcttttt 2586001 tcattcgttt cgatccaatc agcgctgata tactctctga ccatattgcc caacgtttta 2586061 tattgatcca gcttggcaga atctttaaag ctttttccgc acgtcatttc cagacgcttt 2586121 aaaaataagt ctgcaaagcg ttctttactc gagaacatcc cgtccactcc ttgtcacctg 2586181 ctcgaaaata cgctgatact ctttagccga cttcccccag ctgtaatctg cattcatagc 2586241 ggtcttcacg atgctcttcc atacatcctg ttggcaataa aacgacagcg ccctttctat 2586301 cgtaaatttc agatcatgcg cattaaaggc ggaaaacgta aagccattgc ccgttccctc 2586361 ttcctcctga taggcacgga cagtgtcgta aagaccgccc gtttccctga caatcggaat 2586421 ggcgccatat tgaagagcaa tgagctgccc caaaccgcac ggctcaaatt tcgacggcat 2586481 caaaaacata tcagagcccg cataaatttg atgggctagc ggctcatcaa acccgatata 2586541 agcccggcac ttctcatgaa aagcaaattc tgcataccgg aaataatctt caaattcacg 2586601 ttctcctgtg cctagcacaa ccagctgtat gtcttgctcc tcaagaagtt cgtgcataat 2586661 tctgcggaca agatcaagcc ccttttgttt agtgagcctt gtcaccatac tgatcagcgg 2586721 aatatcgttt ttctctggaa gccccatccg ctgctgaagc ttcgttttgt tttccagctt 2586781 gcatgcaaga tcccctgaat cgtattgcgc ctctatataa gggtcgcttt tcggctgata 2586841 gaacgtatca tcaatgccat ttaatatgcc ggttacatca tcttccctat attgcaaaac 2586901 ctgttccaac tgctcaccat aatacggcgt catgatttca tttctgtaag tggggctcac 2586961 agttgtcaca tgatcagccg caatgatgcc cgctttcata aaattaacaa atccgttgca 2587021 ttctaacctt tcataatgaa aatgatccat ctcaagaccc agcaagtcat gtgtgacatc 2587081 aggagggaat atgccttgaa actgcaggtt gtggatcgtg agcacgcttt tcatccgttc 2587141 ataaaaagga tgttttctgt actcctcttt cagcaaataa ttgaccatcg ctgtatgcca 2587201 atcgtgagta tgaacaatat cggcttgaac attcacaact ttggcagcct ccagcacagc 2587261 tcttgaaaaa aaggcaaacc gctcaccgtc atcataatgc ccgtacaacg aatccctgtt 2587321 gaaatagtac tcattgtcga tgaagtaata attcacatca ttctctgcca tatgttcaat 2587381 tccgcaatat tgctgccgcc agccgacagc tacggtacac tcagcctgtt ttttcatacg 2587441 ctttttccac ggttcaggta tttggctgta cttcggcagc atcacagcta cctcattgcc 2587501 taatcgcgca agcgcctttg gcagagcacc tgctacatcg gcaagacctc ctgatttcac 2587561 aaatggggtg cattctgaca cagcaaataa tatcttcaag aattcatcag ctctccttgc 2587621 accaaacctt ttcttaatac aagcggctgc tcagctgttc ctgcagcttc cgtcgccttg 2587681 ccgattttaa catccttatc cgaaatgacc tgctcaagaa gacaatcctc tccaatctgc 2587741 gttttttgca taataatgca gtttttcagc ttcgtaccct ttccgacatg gaccgccctg 2587801 aacaaaatgc agttttcaac ctctccttca agcacacagc cgtttgccac caaagaattt 2587861 ttgacagtgc tgtgctttcc gtatttcgta ggcggctcat ccttcacttt tgtatagatc 2587921 ggctgctgcg gcaaaaacac ctgctgccaa aaacgaggct gaatgagctc catactgtgg 2587981 gtataatatt tttccaccga atcaatgaca gcggcataac ctgaatattc ataagggcaa 2588041 atggtcaggg cggaagattc cttttcaaca gcctcctgaa tggttttata gcctttttcg 2588101 ctatgtccgt agatcagatc ctttaaaagc gttgttgaca tgatatagat ttgcagcgac 2588161 tggccgtcct gaaatacctc ggtgacgtcg cagccaacct cctgatggcg tttcagcaca 2588221 tattgaaatt gaatgttgca tacggtatgg ctgttggaga ttacagcata ttgctgagtg 2588281 cttctgtgga agtaatctag atggtccgaa aactggcgaa aggaaccgaa ttcatcgtat 2588341 tcgtgatgaa gatggggaga cgggaaaaaa aagaggccgt cctttttccg gtgcaaatcc 2588401 cattccttac ccgccccaag gtgatccatg agcgaacggt aacgatactt cggaaaaatt 2588461 gcaacactcc taatatccgc attcaccatg ttggaaagca taaaatcaat cagtcggtac 2588521 ctgccggcaa aagggatcgc cccgagcgac cgctgtgctg ttaaatcctg aagagaatgc 2588581 ttatatgtgg tttcatctat aacacctaac atttgattat tgaacactga ctctgccccc 2588641 tcttcagtaa ttaaatcaat tctttttcta caaattcctc tgaaacgagc agcacctctt 2588701 caatgtcttt ttcggagcga atcactgcgc catccggcag caccatccca ttaggaacga 2588761 tggcattttc aatgactaca tgctccccaa tcgtcacatc cggcattatg acggatgatg 2588821 taacagtcgt atgcttacca acagtcacac cttgaaaaag aacggagtga gacacatttc 2588881 catatacaac acaaccttcg ttcacaagcg aatcttgaac ctgcgcatca gatgaaataa 2588941 attgcggagg ctgatttgga ttgacggagt aaattttcca tttgcgttca aacagcttca 2589001 gctccgagtc ctcttttaac aaatccatat tggcttccca caagctctgc accgttccga 2589061 catccttcca atatcccttg aacggataag cagaaagctt ctttttctct tccaaaagca 2589121 gtggaataat gtctttgccg aagtcgtggc tagaataagg gttttgatcg tccatctcaa 2589181 gatactgttt caaaagcggc caattgaata tataaattcc cattgaggca agattgctct 2589241 tagggaattt gggcttttca tcaaaatgtg tgatcgtccc atctggattg gccttcatga 2589301 tgccgaaccg gcttgcttcc tcccagccca cttcgatgac agagatggtc acatctgctt 2589361 tcttttcaat gtgataatca agcattttgc cgtagtccat tttgtatatg tgatctcctg 2589421 ataaaatcag tacatactca ggatcatact gattcaaata attgagattt tcataaatgg 2589481 agcttgccgt ccctttatac catttgactt ctgatgactc ggcataaggg ggtaaaaccg 2589541 tcacgccgcc attatatcta tccaggtccc atgcactgcc gatcccaata taggaattca 2589601 gctcgagcgg ctgatattgc gttaaaatcc cgactgtgtc tatgcctgaa ttagaacagt 2589661 tgcttagggt aaaatcaata atcctgtatt ttcccccgaa agatacagcc ggtttggcca 2589721 tattttttgt taatccgctg agacggctgc ccttcccgcc ggcaaggagc atggctacac 2589781 attgtttttt catcttttta tctctcctct ttttttaacc gcccgtaaaa tcgagatgcc 2589841 gtaagggggg atggtcatcg tgatataaca cggtttatga tgaagtgctc cctttttagc 2589901 cgataacggc tttttgttga tttgccctga gcctccatat gtttcactgt cactgttaag 2589961 cacttcaatg tattgagtaa aaaaaggaac tccaacatca tattgatgat agaccacggg 2590021 tgtaaaatta caaatgatga caagcgcctc accgtgcttt tggccataac gaataaaaga 2590081 aaagattgat tgttcgtcat tatggacatc aatccattca aacgattgtg cacgatggtc 2590141 atgctcataa aggattttgc ttttttggta aaagcggaga agatcttgcg taaaaacgct 2590201 ggctttctga tgcatgggga aggagtccaa aaaccaatca agctgttctg tatctttcca 2590261 ttcatcaaat tgagcaaact ctgatcccat aaagatcaat ttctttccgg gatgcactgt 2590321 catatagccc agcaaaagcc gatactgggc aaatttctgc cagtagtcgc caggcatttt 2590381 attgagaagt gatttttttc cgtatacgac ttcatcatga gaaaacggca atacaaaatg 2590441 ttcactaaac gcatatagta atgaaaaaga gataagctga tgacaatgcc gcctttcttc 2590501 gggcggcgtc tccatgtatt tcagtacgtc attcatccat cccatattcc atttataatg 2590561 aaaaccaagc cccccttcct caacggcacc tgtcacttga ggccattctg tagaatcttc 2590621 tgcaatcatc atcacatggg gatatgcctc tctcatggtt tgattgagtt tttttaaaaa 2590681 atcaacagca tatggattcg tgtggcgttc atcctgattt ggccaataca agatattagc 2590741 cactgcatca accctaaatc catctatatg atagaattcc gcccagtaca acgcattcga 2590801 aattaaaaaa ctatgaactt ccggtttccc caggtcaaag tttgccgtgc cccataacca 2590861 gttctcccga tcacgttctt ctttgtattc ataaagcggt tctccatcaa acatataaag 2590921 gccatgtgca tctttacaaa aatgtccggg gacccaatcc aaaatgactc cgatattttg 2590981 ttgatgacat tcatccacaa acttcatcag atcatgcggc gggccaaacc tgcttgtcgg 2591041 gctgtaatac cccgttcctt ggtaccccca tgaacgatca tatggatgct catacacggg 2591101 aagcagttca atatgggtaa acccatgctt cttgatataa gggataagcg tctgacttaa 2591161 ttctttatag gaataatgcc tgccatcaga atgcttcttc caagacccaa gatgcagttc 2591221 ataaatgaaa acaggttttt catacagcgt cttagccttc tgtttctttt gccatttttg 2591281 atcttgccag ctgtatcctt ccaaatcgta agtaagtgac gctgtgtttg gtctgacttc 2591341 tgaataaata gcgtatggat ctgccttcag cctgatctca ccgttattcg tcacaatttc 2591401 gtatttatat cgttcctttt ctcctatacc tggaataaat aacgtccaaa tgccattatc 2591461 attcactctg tgcatcacat gctcttctcc agaccagctg ttaaaatctc cagccactcg 2591521 tacttccgac gcatgaggcg cccacacaca gaattcatat ccgcttttgc cattcagctc 2591581 gcggtaatgc gagccaaaca gctgatagct tttaaacaga ctgccttcgt gaaaaagata 2591641 aacatcatgt gctgtcgggc tggcagcggc catgtaatca tcctttctga catcatagtt 2591701 ttcatttata gtatttattc gaagaaataa aaaaaagccc tttcctgaaa gcgcttatac 2591761 ttatagacaa ttaacttcat tttctgaaga aaaacgaaat atatggagat ttttgtagtc 2591821 tgtttttaaa ataaagaaca aaatctaaga catatcatga tttataaaaa caaaaaaacc 2591881 ttgcaggata tgcaaggctt ctggatgacc cgtacgggat tcgaacccgt gttaccgccg 2591941 tgaaagggcg gtgtcttaac cgcttgacca acgggccgat aattatgata tctgtaatca 2592001 tatggcggag aaggagggat ttgaaccctc gcgccgctta cacgacctac acccttagca 2592061 ggggcgcctc ttcagccact tgagtacttc tccatttggc tccacaggca ggattcgaac 2592121 ctgcgaccga tcggttaaca gccgatagct ctaccactga gctactgtgg aacaaaagtc 2592181 atggtgggcc tgaatggact cgaaccatcg acctcacgct tatcaggcgt gcgctctaac 2592241 cagctgagct acaggcccat gacgatatag aaatggagcg ggtgatggga atcgaaccca 2592301 cgacatcagc ttggaaggct gaggttttac cactaaacta cacccgcaat ttttatttgg 2592361 ggcgattgat gggaatcgaa cccacgaatg ccagagccac aatctggtgc gttaaccact 2592421 tcgccacaac cgccaaagca tattgataaa tggtggctcg ggacggaatc gaaccgccga 2592481 cacacggatt ttcagtccgt tgctctacca actgagctac cgagcctaag tatttaaatg 2592541 gcggtccgga cgggactcga acccgcgacc tcctgcgtga caggcaggca ttctaaccaa 2592601 ctgaactacc ggaccatttt aaaatttggt tgcgggggca ggatttgaac ctgcgacctt 2592661 cgggttatga gcccgacgag ctaccgaact gctccacccc gcgatgatta ggaatatgta 2592721 tggcggagga agagggattc gaacccccgc gggctttgac acccctgtcg gttttcaaga 2592781 ccgatccctt cagccagact tgggtattcc tccgtatagt ggtggacctt gtaggactcg 2592841 aacctacgac cggacggtta tgagccgtct gctctaacca actgagctaa aggtccattg 2592901 gtagcggcgg aggggatcga acccccgacc tcacgggtat gaaccgtacg ctctagccag 2592961 ctgagctaca ccgccaaata tttttgaaat caagtggagc ctagcgggat cgaaccgctg 2593021 acctcctgcg tgcaaagcag gcgctctccc agctgagcta aggccccaag aatggtcggg 2593081 aagacaggat tcgaacctgc gaccccatgg tcccaaacca tgtgctctac caagctgagc 2593141 tacttcccga tttcatatag atcatggcgc gcccgagagg agtcgaaccc ctaacctttt 2593201 gatccgtagt caaacgctct atccaattga gctacgggcg caaaacttaa tgccgagggc 2593261 cggacttgaa ccggcacggt agtcacctac cgcaggattt taagtcctgt gtgtctgcca 2593321 attccaccac cccggcgtgg atggtatagt tggagcggaa gacgggattc gaacccgcga 2593381 cccccacctt ggcaaggtgg tgttctacca ctgaactact tccgcagaaa tggtgcggat 2593441 gaagggactt gaacccccac gtctgtaaag acactagagc ctgattctag cgcgtctgcc 2593501 aattccgcca catccgcaac atgtaaatgg tgagccatga aggactcgaa ccttcgaccc 2593561 tctgattaaa agtcagatgc tctaccaact gagctaatgg ctcttcttac aatagacttg 2593621 aatattatat catataaaag tggtgccggc aagaggactt gaacccccaa cctactgatt 2593681 acaagtcagt tgctctacca attgagctac accggcatat atgtaaaacc gatatgtata 2593741 atgaaaaatg gtggaggatg acgggctcga accgccgacc ctctgcttgt aaggcagatg 2593801 ctctcccagc tgagctaatc ctccatactt gcactaacgt gcaattgctt ggcggcgtcc 2593861 tactctcaca gggggaaacc cccgactacc atcggcgctg aagagcttaa cttccgtgtt 2593921 cggtatggga acgggtgtga cctcttcgct atcgccacca aacaaattga gagtgttctc 2593981 tcaaaactag ataacaggtg tgacatcatt caaaaatatg gttaagtcct cgatcgatta 2594041 gtatctgtca gctccatgtg ttgccacact tccacctcag acctatcaac ctgatcatct 2594101 ttcagggatc ttacttcctt gcggaatggg aaatctcatc ttgagggggg cttcatgctt 2594161 agatgctttc agcacttatc ccgtccgcac atagctaccc agcgatgccc ttggcagaac 2594221 aactggtaca ccagcggtgc gtccatcccg gtcctctcgt actaaggaca gctcctctca 2594281 aatttcctgc gcccgcgacg gatagggacc gaactgtctc acgacgttct gaacccagct 2594341 cgcgtaccgc tttaatgggc gaacagccca acccttggga ccgactacag ccccaggatg 2594401 cgatgagccg acatcgaggt gccaaacctc cccgtcgatg tggactcttg ggggagataa 2594461 gcctgttatc cccggggtag cttttatccg ttgagcgatg gcccttccat gcggaaccac 2594521 cggatcacta agcccgactt tcgtccctgc tcgacttgta ggtctcgcag tcaagctccc 2594581 ttgtgccttt acactctgcg aatgatttcc aaccattctg agggaacctt tgggcgcctc 2594641 cgttaccttt taggaggcga ccgccccagt caaactgccc acctgacact gtctccccgc 2594701 ccgataaggg cggcgggtta gaaggtcaat acagccaggg tagtatccca ccgatgcctc 2594761 caccgaagct ggcgctccgg tttccaaggc tcctacctat cctgtacaag ctgtaccaac 2594821 attcaatatc aggctgcagt aaagctccac ggggtctttc cgtcctgtcg cgggtaacct 2594881 gcatcttcac aggtactata atttcaccga gtctctcgtt gagacagtgc ccagatcgtt 2594941 gcgcctttcg tgcgggtcgg aacttacccg acaaggaatt tcgctacctt aggaccgtta 2595001 tagttacggc cgccgtttac tggggcttca attcgcacct tcgcttacgc taagcgctcc 2595061 tcttaacctt ccagcaccgg gcaggcgtca gcccctatac ttcgccttac ggcttcgcag 2595121 agacctgtgt ttttgctaaa cagtcgcctg ggcctattca ctgcggctct ctcgggcttg 2595181 caccctaaca gagcacccct tctcccgaag ttacggggtc attttgccga gttccttaac 2595241 gagagttctc tcgatcacct taggattctc tcctcgccta cctgtgtcgg tttgcggtac 2595301 gggcacctct cacctcgcta gaggcttttc ttggcagtgt ggaatcagga acttcgctac 2595361 tatatttcgc tcgccatcac agctcagcct tatgggaaac ggatttgcct atttcccagc 2595421 ctaactgctt ggacgcggat atccaatacc gcgcttaccc tatcctcctg cgtcccccca 2595481 ttgctcaaat ggtgaggagg tggtacagga atatcaacct gttgtccatc gcctacgcct 2595541 ttcggcctcg gcttaggtcc cgactaaccc tgagcggacg agccttcctc aggaaacctt 2595601 aggcattcgg tggaggggat tctcacccct ctttcgctac tcataccggc attctcactt 2595661 ctaagcgctc caccagtcct tccggtctgg cttcacagcc cttagaacgc tctcctacca 2595721 ctgttcgaag aacagtccgc agcttcggtg atacgtttag ccccggtaca ttttcggcgc 2595781 agagtcactc gaccagtgag ctattacgca ctctttaaat ggtggctgct tctaagccaa 2595841 catcctggtt gtctaagcaa ctccacatcc ttttccactt aacgtatact ttgggacctt 2595901 agctggcggt ctgggctgtt tccctttcga ctacggatct tatcactcgc agtctgactc 2595961 ccaaggataa gtcattggca ttcggagttt gactgaattc ggtaacccgg taggggcccc 2596021 tagtccaatc agtgctctac ctccaagact cttaccttga ggctagccct aaagctattt 2596081 cggagagaac cagctatctc caggttcgat tggcatttca cccctaccca cacctcatcc 2596141 ccgcactttt caacgtgcgt gggttcgggc ctccattcag tgttacctga acttcaccct 2596201 ggacatgggt agatcacctg gtttcgggtc tacgaccacg tactcatgcg ccctattcag 2596261 actcgctttc gctgcggctc cgcatcttct gcttaacctt gcacgggatc gtaactcgcc 2596321 ggttcattct acaaaaggca cgccatcacc cgttaacggg ctctgactac ttgtaggcac 2596381 acggtttcag gatctctttc actccccttc cggggtgctt ttcacctttc cctcacggta 2596441 ctggttcact atcggtcact agggagtatt tagccttggg agatggtcct cccggattcc 2596501 gacggaattt cacgtgttcc gccgtactca ggatccactc aggagagaac gaagttttga 2596561 ctacagggct gttacctcct atggcgggcc tttccagacc tcttcatcta cctcgttctt 2596621 ttgtaactcc gtacagagtg tcctacaacc ccaagaggca agcctcttgg tttgggctga 2596681 tcccgtttcg ctcgccgcta ctcagggaat cgcatttgct ttctcttcct ccgggtactt 2596741 agatgtttca gttccccggg tctgccttct catatcctat gaattcagat atggatacca 2596801 ctccattacg agtggtgggt ttccccattc ggaaatctcc ggatcaaagc ttgcttacag 2596861 ctccccgaag catatcggtg ttcgtcccgt ccttcatcgg ctcctagtgc caaggcatcc 2596921 accgtgcgcc ctttctaact taaccgttaa aaagaatcac tatgtgatat cttgtgttac 2596981 taattgaatg tgatgtctac tgttatctag ttttcaaaga acacgtttcg aaggaatgat 2597041 ccttcaaaac taaacaagac agggaacgtt ctgtttataa gaccttgggt cttatattcc 2597101 gtataatatc cttagaaagg aggtgatcca gccgcacctt ccgatacggc taccttgtta 2597161 cgacttcacc ccaatcatct gtcccacctt cggcggctgg ctcctaaaag gttacctcac 2597221 cgacttcggg tgttacaaac tctcgtggtg tgacgggcgg tgtgtacaag gcccgggaac 2597281 gtattcaccg cggcatgctg atccgcgatt actagcgatt ccagcttcac gcagtcgagt 2597341 tgcagactgc gatccgaact gagaacagat ttgtgggatt ggcttaacct cgcggtttcg 2597401 ctgccctttg ttctgtccat tgtagcacgt gtgtagccca ggtcataagg ggcatgatga 2597461 tttgacgtca tccccacctt cctccggttt gtcaccggca gtcaccttag agtgcccaac 2597521 tgaatgctgg caactaagat caagggttgc gctcgttgcg ggacttaacc caacatctca 2597581 cgacacgagc tgacgacaac catgcaccac ctgtcactct gcccccgaag gggacgtcct 2597641 atctctagga ttgtcagagg atgtcaagac ctggtaaggt tcttcgcgtt gcttcgaatt 2597701 aaaccacatg ctccaccgct tgtgcgggcc cccgtcaatt cctttgagtt tcagtcttgc 2597761 gaccgtactc cccaggcgga gtgcttaatg cgttagctgc agcactaagg ggcggaaacc 2597821 ccctaacact tagcactcat cgtttacggc gtggactacc agggtatcta atcctgttcg 2597881 ctccccacgc tttcgctcct cagcgtcagt tacagaccag agagtcgcct tcgccactgg 2597941 tgttcctcca catctctacg catttcaccg ctacacgtgg aattccactc tcctcttctg 2598001 cactcaagtt ccccagtttc caatgaccct ccccggttga gccgggggct ttcacatcag 2598061 acttaagaaa ccgcctgcga gccctttacg cccaataatt ccggaaaacg cttgccacct 2598121 acgtattacc gcggctgctg gcacgtagtt agccgtggct ttctggttag gtaccgtcaa 2598181 ggtaccgccc tgttcgaacg gtacttgttc ttccctaaca acagagcttt acgatccgaa 2598241 aaccttcatc actcacgcgg cgttgctccg tcagactttc gtccattgcg gaagattccc 2598301 tactgctgcc tcccgtagga gtctgggccg tgtctcagtc ccagtgtggc cgatcaccct 2598361 ctcaggtcgg ctacgcatcg ttgccttggt gagccgttac ctcaccaact agctaatgcg 2598421 ccgcgggtcc atctgtaagt ggtagccgaa gccacctttt atgtttgaac catgcggttc 2598481 aaacaaccat ccggtattag ccccggtttc ccggagttat cccagtctta caggcaggtt 2598541 acccacgtgt tactcacccg tccgccgcta acatcaggga gcaagctccc acctgtccgc 2598601 tcgacttgca tgtattaggc acgccgccag cgttcgtcct gagccaggat caaactctcc 2598661 gataaatgga tcacaggtta agttcaccgc atcctgcggc gacacctgtg tgacctgcgt 2598721 cgtgcaggcc ctagtttgac tgactacgca catcgcagtg cgatttttaa aaactgaatt 2598781 aacaggtacg ttttgtcttg tttagttttc aaagatcatt tcgttacttc tcaatgaagc 2598841 agctttacta atataacatt cagcttcttt tttgtcaaca acttttttca agttgttttg 2598901 aagcatctag tttgtgtccg ctgtgcatca gcgacgttta ataatataac acctgtattt 2598961 atttattgca atagtttttt aaaaaaaatc tataaaacaa ataaactata atcctcgcca 2599021 tgatttctaa agcgtgtgta tcatataagt ttcttaaaag aacatataca tcagtcatgt 2599081 gatcttgttg tttttttcgt tttcttgtat agtagaaacg aactaaatac tgatgaccac 2599141 aaggggagca ttaaagctga gagtgagcgg tttcgttctg accctttgaa cctgttagtt 2599201 aacgctggcg tagggatgtg gcaaagtcaa atgaattgca gatcgtaaag cagtgcgtgg 2599261 aacttttctc atccttccgc gtgctgcttt tttgttgtcc ttttggttgt ctgtcaatgg 2599321 aaggagatag atatgaatca atctaagcaa ctggttcgcc ttattgaaat tgccattatg 2599381 acagcggcag ccgttatttt agacattgtc tcaggaatgt ttcttagcat gcctcaagga 2599441 ggctcggtct ccatcatgat gattccgatc tttttaattt cgtttcgctg gggtgtcaaa 2599501 gcaggtctta ctacaggttt gttgacaggt ctagtacaaa tagcaatcgg aaacttgttt 2599561 gctcaacatc ctgtacagct attgttagat tacattgtcg ctttcgcagc aatcggcata 2599621 agcggctgtt tcgcttcttc tgtccgtaaa gccgctgtat caaaaacaaa agggaaattg 2599681 attgtttcag tggtcagcgc agtttttatc ggcagtttgc tgcgctatgc cgcgcatgtc 2599741 atttcaggag ctgtgttttt cggcagcttt gctccaaaag gaacaccggt atggatttat 2599801 tctttaactt ataatgcgac ttacatggtt ccttcattca ttatttgtgc aattgtccta 2599861 tgtttattat ttatgacagc accccgtctg cttaaaagtg acaaagcgta aaagtaacaa 2599921 tcccccagcg aattccgctg ggggattttt cgttatctgt taagaagtgt ttttaaagct 2599981 gaaagatccg gccagccaag acctacttct ttcagcctta ctccggcaat ttcaaagttg 2600041 tcctccgcta ctctttcagg tgaataggcc tgataaaata taatcgaggg attctgctca 2600101 ataacccaaa caaacatact tgaaaaacca tgttgaagca aaaactccgc tccttttgct 2600161 aagagcgccc tgcctgcacc ttgccgctgg cgctcttcca gaagataaat agcgtataac 2600221 tcgccgtcat agccttcttg ttcagagcga ataggtccaa atgaagcaaa gccgaatact 2600281 gaaccctttt cgtcctgagc aacaaatact ccctttaacg agcgactttt ccatttgtct 2600341 tcaaattcct tatagttcag gctgtttaaa taatcaatcg ggataatttc gtggtatgtt 2600401 gtcctccagc tgtctacatg cacttttgca atgtccttta tatcctctaa cttcgcttca 2600461 cgtacagtta ccatacggtt ctgccctttc cttactctga tttttggatc gttttggctt 2600521 ctttgatttc atttgttaat tcattaatgc tttgttttac gtttcctttt cctgaaaagt 2600581 tctcaagcat ttcttttaca tcaattcctg aggatgcttt taaactttct tgcagacttg 2600641 acattaagtt cgtcgcatag ctggttactt tgtttgctcc gcttgattca ccgcttcctc 2600701 ctgtatcgac aacggtgatt ttatcaatat ttgaaagagg tgccgctgct tgtttcgcgt 2600761 attccggaag cattttgaca atcatatcga aaatcgccgc ctgcccgtac tgttcaaagg 2600821 cggccgcaat tttctctttt gcttccgctt ctgcaagacc tttcaggcgg ataacctctg 2600881 cttctgtctc tcctttcgct ttttccgctt ctgcttttgc tagcccgtca attcttactt 2600941 tttccgcctc agcctttgcc attgcttcaa tactgtactt cttggcatcg gcttccgcga 2601001 gctgtttggc tttctcagct gctgcggact gctcaacaga ataacggtct gcatcggctt 2601061 ttttctttac ctctgagtcg tattgacgtt cacggcgaag aatttctttt tcttctagtt 2601121 ctatttgttt ttggcgttcg ataattttaa cctgcatttc ctgctctgtg acttgctggc 2601181 gcgctcgggc agtctctaaa tcatatgctt ggtcggcatt cgcttttgcc gtatcttgtt 2601241 ctctgcggaa ttcagccatt ttgagctgat tgattttttc agcttcagcg atttccgtcg 2601301 cccgttcaag ttctgatttt tttgcgtctt tatcggcttc tgcccgctta attcgggttt 2601361 ctttatcagc ctctgctgtt gcgatatcag catcgcgttt tacttgggca attctcggtt 2601421 tccctaatga ttcaagataa ccgtttttat cacgaacatc tttaatggta aacgagacga 2601481 ttacaagtcc cattttcgcg agatcctgtg aagcgacacg ctgcacctct tgagagaatt 2601541 tttctctgtt tttatagatt tcttctactg tcattgagcc gagaatggaa cgaaggtggc 2601601 cttctaaaac ctcccgcgct tcctgctcac ggtcgtcttt tgatttccct aaaaattgtt 2601661 cggccgctgt agcgatttct cctatagaac cgccgatttt aataatcgca gttccatcgg 2601721 ccattactgg cactccttgt tctgtataga cttcaggtgt cgaaacatcg agtttgcttg 2601781 ataataggct tagcggctct gcctgctgga agacgggaag gacaaaggtt cctccgccgc 2601841 ggacgatttt aatacggttg ccgccttcat cgacatgaac atttttatta cccagatagc 2601901 tccctgttac aattaacgct tcatcaggcc ctgctgtacg atacttcgta ataaacacag 2601961 ctattagtgc aattaataaa aagaatacaa ctccgatgat cattataatc ggcattgtca 2602021 tatcaaattc ctccttttat gttaaatggg ttcatgcgga gtaaccgaaa gaactccgtt 2602081 gttaatatct acgactaaca ccgttgtccc gtaactgatc tgctgattat caaaactgac 2602141 cgctgacttt gaaatggtcc cgcctatccc ttctatgacc acttcaccaa acccgtcaac 2602201 cggcacagct gtaatcactt taccgagtct tcctctgaga tcatcttctc tatatgccaa 2602261 tgattcttct gcagatgata atggcaccag tacaaagatg tgaagcaata ccaccagcat 2602321 gatcgaaagg atgcaagata aaagcgcaat cagcaagctt gacagaggca atacaagttc 2602381 acctatatat ccgcccgctg aaaaacatgt aaaaaatgag agcactaatg tcggattaag 2602441 aaacggaatg ccttctgaca gccctgaaaa tacatctccg aaaaacagga ataacagcgt 2602501 aaggctgccc gcaataataa gcgtataaag atacattgtt tgtataggta ctccaaataa 2602561 ctccaacttc ctcatccttt cttcatcaat gcattgatga acggctgccg ttaccattta 2602621 tacgagacac ctcgggaaaa gtttcaaaat tttaagacaa ataacccatt tgaagtgctt 2602681 tataaatgat aattgcttat atatatggta atgtcatttt aggaggagat atgatgagta 2602741 tctttaatga agccagatta gaaacgtgga acgaattgaa aggactttct gacgaaaagc 2602801 tgaatcaaaa gccttctgct gaagaatgga gcatacggga agttcttgac catttgaaaa 2602861 aaatcgatat gaccgcacaa aaaatgttga aggaacgtgt aaaggacgct ccgattaaag 2602921 aaattgaaga aaaaccgctt gaagtagcac aggacagaaa taataaacgg aaagccccga 2602981 gtcatcttga gcctgcgcat gattttattt caggcagcca aatgaaacgt gagcttgatg 2603041 tggtaagaga gcagctgact gctgcgattg cctctctgaa agaagaagat tttgaaagag 2603101 tgcttccgca tcctgtgttt caagagctga ctgtcagaca gtggatcgat tttatcggcc 2603161 atcatgaaaa acggcacctc agccaaatga aagaaattaa agaaaagata gaaagggcct 2603221 gatttaatca gaccctttct gcttttcgtt tgacttttcg ctgataggaa tgaacttcta 2603281 tttcatcacc tgtgtaaaca gcaccaggtc tctccacaat acagacaatc cctctaatgc 2603341 ccagtgcgtg gcggacgaaa gccgacgcca gcttcggttg gtccggataa taagactgaa 2603401 tgacttctcc cggctggata cacggatcat tttcgccctc acacagcaga gccgctccgc 2603461 tcggaaaaat aatccggctt ccttctttta atgaagtaag atctggcata ccgctgactg 2603521 ccacattcgc cccgagccat tccggcaaaa ttctcggcac tcccattttt aaagcgattt 2603581 cgttgcattc ctctattgaa acaattgaaa tttgtctgcg gttgaaaatt tcagtccctc 2603641 ttgaaaacat tggttctctg gctcccgctt ttttggtcag gccaaaatgc aagtcgccgg 2603701 ggatgccgcc ataatcaaaa tcaagcttgt ccatttgctt tgttacgaag ctttttgtat 2603761 ctgcgatata taagccttcc gcttttgcag tcatacgctt ccacatcagc tggcaccttc 2603821 cttcttatct aaaatttcca cctatgcttc attatcccaa aaaatcccgc tctgtaaagg 2603881 agcgggattt tgattatacc gttttaggcg taaggttaaa gcagcgtttg tagatccagt 2603941 tgtatgcttt ttcatttaaa tctctagggt ttccgaaggt ttgcggatct ttcattgctt 2604001 ctttagacaa gcgttcgatc atatcaggtg atactccctg ctcttctaaa gtcggcactt 2604061 ctaaatcttc gaccagatca tacatccaat tgacagatgc tttcgcagct tcttctgttg 2604121 tcatcttgct tgtatcaata ccgaacgctt tcgcaatacg cgcaaacttc tcaggatagc 2604181 ccttccagtt gtattccatg acagggccca tcatcgccgc tacacattgg ccgtgagcga 2604241 ctgggataat accgccaagc gtttggctca tcgcatgagc agcgcccgct gattcacttc 2604301 cgtaagaaag accggcaagc atcgcagcct gcgccattcc gtaccttgct tccagatcct 2604361 ctccatcagc aaatgccctc ttgatgtaat gagcggcata ctcaatcgcc attaaggcaa 2604421 ccgcatccgt gattggctgt gcaaatttca ttgtatagca ctcaatggca tgggcgagcg 2604481 catcaattcc cgtcatagct gttacatgcg gaggcattga aacatgaagc tcaggatcaa 2604541 tgattgtcaa gtgcgctgca atcagcggac cgcccgtgtt gaatttgaat tctctttctt 2604601 catctgtgat aaccgcccat tgggttactt ctgatccggt tccagctgta gtgggaattg 2604661 tcgtcagcgg aggaatgcgg ttttccagcg gttttttccc atctgccgct tcataatcaa 2604721 gcacgcttcc ttcgtgagtc gcttctactc cgattgcttt tgctgtatcc atggagcttc 2604781 cgcctccgac tgccaccaaa ccattacagt tctctttttt gtaaagctca gatccttcat 2604841 tcaccagacg gacaggcggg tttggctcaa ctttattaaa gagtaccact tcaatgcctg 2604901 cttctttaag tgattcgatt acgggatcag caacaccggc tttataaatc ccagggtctg 2604961 tgacaaggag cgcttttgaa acgcccagtg cagctacttc ctcacccgta tgcttgatgg 2605021 ctccgattcc atgcttaatc acagtcggaa tttcaaatgt gtggaatttc tgcatgcttt 2605081 ctaccttcat atttaatgtc atcatcaatc tccccctctt atgaattaaa ccagttaacc 2605141 gctgccggtt ttgtattgcg gtatacatgt ttgacttctg tgtattcttc aaggcctatt 2605201 tttccaagct cgcgtccgaa cccggattgc ttatatccgc cccatggcgc ttgtgcaaag 2605261 tacggatgaa aatcgttgat ccaaacggtt cccattctca agcgggctgc tacccgttcg 2605321 cacttttcaa tgtcttttga ccataccgct ccagccaagc catagatggt atcattcgca 2605381 agctcgatta cctcttcttc agagctgaag gtttcgactg tcaatacagg accgaaaacc 2605441 tcttcctgaa cgattctcat gtcagaatta cagtttgaga aaatagtagg ttcatagaaa 2605501 aagccgtttt gaagctcagg atcttccggg cgtttgcctc ctgtctccag cttcgcgcct 2605561 tcctctattc cgatctctac atatttttct acctttgccc tgtgctccgc cgaaataagc 2605621 ggaccgcttt ctgtctcagc atgaaaaccg tttccgagtt ttatgcgttt tgcccgtttg 2605681 accagctccg ccaaaaattg atcatgaatg gcatcctcaa caagcaagcg ggaacctgca 2605741 gagcatactt ggccggcgtg gaaaaataca gcgtttaagg cctgatcaac cgcaacttct 2605801 aaatccgcgt ccttgaaaac aatatttggg tttttcccgc caagttcaag ggcgattttt 2605861 ttgacgtttc cgcttgccgc ccgcatgatt tttttgcctg tttcaattcc gcccgtaaat 2605921 gaaatcaaat cgacgtcttt gtttacggca agctcgtcgc ccactgtggc tcccggtcca 2605981 agaacaagat ttgcgacacc ttttggaaca ccggcttctt ccatcagctt aaagactttg 2606041 attgtcgtca gcggcgtaat ctcactcggc ttcatgacga ttgtgtttcc tgcggccagt 2606101 gcaggggcga ttttccagct cgcttgaagg agcggataat tccatggagt gatctggccg 2606161 caaaccccga ttggctccct aataattttg ctttctgaat caggaatcgg agatgaaatg 2606221 atctctccgc catctttgtc tgccaagccg gcgtaatatt gaaaaacatt ggcgatatcg 2606281 tccatatcgg ccttgctttc ttcgagtgtt tttcctgtat caagagattc aagctcagcc 2606341 agctcctcaa gatcgcgtct gattaattcc gcaattttca gaacaatttt tccgcgttca 2606401 agcccggata gcgatgacca ttctcctttg tcaaatgctc tacgtgcggc tgcgattgct 2606461 ttgatggcgt cctctcgccc tccctcgctt acagttgcaa tttcttcttg attaaatggg 2606521 ttgataatac tgcggatctg ttctttttcg gcactgatcc attctccgtc aatgaataat 2606581 gtttgactca tataagcctc cttgacgtaa ataaagtttg ttaaataaaa atttaatgtt 2606641 tttaacaacc ttaatctaac atatggtttt taaactgtca aagtcccatt ttgatttttc 2606701 tttttgactt ttcctcatgt ttcgttaaga taaagaacat aaagaaataa cttaacgaat 2606761 ttaattttct aaaggaaaag agggtcagta tggatgaaaa tccagaattt gcagctatag 2606821 aacaggctcg ggatcttgtt attgactcca ttgctgaaac gatggatctt tacggaatta 2606881 cccgcagtgt cgggatttta tatgggacga tgtatatgag ggatgagatg acgcttgacg 2606941 aaatgcgtga ggagttgcaa atgagcaaac caagcatgag cactggcgtc aaaaagcttc 2607001 aagacttaaa tgtagtgaaa aaaacatttc accggggcat ccgcaagcat acatttgtgg 2607061 ctgagaagga tttctttaaa tttttcacaa atttctttcc acctaaatgg gagcgggagg 2607121 ttcaagtgaa tgtaacagcg atcgaggaag ctcaagctga tttacaaaag gttttatgca 2607181 aggaagatct cgatgaggat atcaaaaatg aagcactgca gttatatgat cagctggaaa 2607241 gctctaaagc ttactatgac tggctgaaac ggcttgctga atcggtgcag accggagaaa 2607301 tttttaaatt tataccggtc gaaacaaagt aaagcagaaa acgcctggga aactaggcgt 2607361 ttttttgatg taactactac aaatttgaaa aatacgggaa aaacacccca tttacttcca 2607421 aaatatttga tggtaatttt atgtaggtaa aatttgtatt tggcctttca gaggaggtga 2607481 aaagcgggca ggcctgttta atttatcatt ttttaggggg aattttgtta tgaaacgcaa 2607541 attattatct tctttggcaa ttagtgcatt aagtctcggg ttactcgttt ctgcacctac 2607601 agcttctttc gcggctgaat ctacatcaac taaagctcat actgaatcca ctatgagaac 2607661 acagtctaca gcttcattgt tcgcaacaat cactggcgcc agcaaaacgg aatggtcttt 2607721 ctcagatatc gaattgactt accgtccaaa cacgcttctc agccttggcg ttatggagtt 2607781 tacattgcca agcggattta ctgcaaacac gaaagacaca ttgaacggaa atgccttgcg 2607841 tacaacacag atcctcaata acgggaaaac agtaagagtt cctttggcac ttgatttgtt 2607901 aggagctggc gaattcaaat taaaactgaa taacaaaaca cttcctgccg ctggtacata 2607961 tactttccgt gcggagaata aatcattaag catcggaaat aaattttacg cagaagccag 2608021 cattgacgtg gctaagcgca gcactcctcc gactcagcct tgcggttgca actaatgtaa 2608081 aagaccggtt aacgccggtc ttttttgcgt tttaccctcc cctttttctc taatccccgt 2608141 tatctttttt ctggtttaaa atttaaattg acaaacacta gaaacaggag taaattcttg 2608201 agtgttcaat ttcatacagt ctcttttacc gcttaatcaa acacgaacgg gggaaccaac 2608261 gattggctgt tttattaaca gccttggggt gaatcttact aagtaagagg gggtactctg 2608321 aatccctaat ccgacagcta acctcgtagg cgtatacaga gaggaggtct attatcggcc 2608381 attctttgca atggtctttt ttgtttcaaa aacgttaatt cactaaggga gatatgaaca 2608441 ttgggaagaa ttaaaaataa gcaatttgcc gtgatcgggc tgggccggtt tggcggcagc 2608501 atttgtaaag aacttcatag aatggggcat gaggtccttg cggttgatat caacgaagaa 2608561 aaggtcaatg catatgcttc ttacgccact catgcggtaa ttgccaacgc caccgaagaa 2608621 aacgaattgc tttcattagg aatacgcaat tttgaatatg tgattgttgc catcggagca 2608681 aatattcaag cgagtacgct gaccacccta ttattaaagg agcttgatat tccaaatatt 2608741 tgggtgaagg ctcaaaacta ttatcatcac aaggtgcttg aaaaaatagg cgctgaccgc 2608801 attattcatc ctgaaaaaga tatgggggtt aaaatcgcac aaagcctttc agacgaaaat 2608861 gttttgaatt acattgatct atctgatgaa tacagtattg tcgagctgct ggctacgcgc 2608921 aagcttgatt caaaatcgat tattgacctg aatgtaagag caaagtacgg ctgcacgatc 2608981 ctggccatta aacatcatgg agatatctgt ctttcccccg cgcctgaaga catcattcgc 2609041 gagcaagatt gcctggtgat catgggccac aaaaaggata ttaaacgttt tgaaaacgaa 2609101 gggatgtaga caaaggtgac acttcaaaag gataaagtga tcaaatgggt tcggtttaca 2609161 ccgcctcaag tgcttgccat tggttttttc cttaccatta tcatcggggc tgtcctatta 2609221 atgcttccga tttccactac gaagccattg tcatggatag atgccctttt tactgcggct 2609281 tccgctacaa ctgttacagg gcttgctgtt gtcgataccg gcactcaatt tacggtattc 2609341 gggcaaacag taattatggg gctgattcag attggcgggc ttggatttat gacatttgcg 2609401 gtcttgatcg tcatgatatt aggaaaaaaa atcggcttaa aagaacgaat gctcgtccag 2609461 gaagccttaa accagccgac aatcggcggt gtcattggcc ttgtcaaagt cctgtttctg 2609521 ttttcgatca gtattgaatt gatagcagca ctcattttat ccatccggct tgtacctcaa 2609581 tacggctggt catccggctt gtttgcaagt ttgtttcacg caatatctgc ttttaacaat 2609641 gccgggtttt cgttgtggcc tgataatttg atgagctacg ttggcgatcc tacagtgaac 2609701 ctcgtgatta ctttcttatt tattacagga gggatcggat ttacggttct gtttgatgtg 2609761 atgaaaaatc ggcgttttaa aactttttct ttacatacaa agctcatgct tacaggaacg 2609821 ctgatgttga atgcgatcgc tatgcttacg gtctttattt tagaatacag caaccccggc 2609881 acgctcggcc acctgcatat agtggataaa ctgtgggcct cctattttca ggcagtgacg 2609941 ccgagaaccg cagggttcaa ttctctagat tttggaagca tgagagaagg aacaattgta 2610001 tttactttat tattgatgtt tatcggagca ggaagcgcat caacggcgag cggcattaag 2610061 ctgactacgt tcatcgtgat tttaacatct gttattgctt acttgagagg taaaaaagaa 2610121 acggttattt tccgccgttc catcaaatat ccgattatca ttaaagcttt agctgtgagc 2610181 gtcaccagtt tgttcatcgt gtttttaggg attttcgccc tgacgatcac agaacaagcg 2610241 ccatttcttc aaattgtgtt tgaaaccttt tccgcattcg gaactgtcgg ccttacgatg 2610301 gggcttactc ctgaactgac aacagctggc aagtgtatca tcattgtcat catgtttatc 2610361 ggaagaattg gtcctttaac gttcgtgttt tcattcgcaa aaacagagca atcaaatatc 2610421 cgttatcctg atggcgaagt gtttacaggg tgatatcaaa aaaatccggc gtgcagtcgc 2610481 cggatttttt atgattcgat atgagattga ttttgtcttt tttcctgttc cgcgatgatt 2610541 tcgttatcct ccgcgttatc acgggtcact ttttgcgtaa gaatcgcacc aactgctaca 2610601 agtatcataa cagcgatgta ataacctttt tcattgagtt ccagattatc agcattatag 2610661 agtccgatac taaacaaaaa tactcccgca aaaaaagtaa aataagctag tactgtaaag 2610721 gcaaccgtgt ttctgcgtct atatttctgc acctttgttc cctcccgaaa gcatagttaa 2610781 aaagtgataa cttccgtgga atattatacc tcaaattccc cggaatggaa caaagaatta 2610841 aaaataccag taaaaagggc ttaggttgcc tcctttattt caacagctga atcatcaatc 2610901 cagccgataa gtttatcatt gatttggaat tggtaccata cagactggcc tttctgtttt 2610961 ttagacacaa cctttatgtc tttgccgacg taagattggg cagaggtaag ccttatggac 2611021 cgatcatcag tagaaggctt ggaccatacg tcttgaacgg cactgtcttt aatagaggcg 2611081 tttaaatcca cagatttgag ggatggattt acctcatcgt actcatctaa atcgtatttt 2611141 tccacaatag cgctgatttt gtcagcgtag tcagggtctg tagcatatcc tgatgtttgc 2611201 agggcggttg ccgcttcctt ataattccct gcctcaagca ccggtttata cttcttttta 2611261 ttccacgatg tgccacggac gaacaattgg gcgtgatcat ccatagattc aaaaaacgtg 2611321 ctgtattttc gaaacttcgc gcgaatggtt tttcttttcc ctttttcaac ttcgtccgtt 2611381 tccatcgtga catgatggcc tttataattc ccttttacgc caaaaaggtt gttggcctta 2611441 gcagccagtt cactgttccc ccagtccgat tcgagaatgg cctgagcaat tgtgatgctg 2611501 gggagaacat ggtatttttc atacaaaatt tgggcatgtc cggacagact gtctataaat 2611561 acttgctgtt catcgatttc ttcagtttct ttggatattt caatcggttt tgataaagtt 2611621 gtcgctaaaa caaacagagc tagcggaatc gatacaagga aaaatagtga aatcaagagt 2611681 ttacgttttt taagtttttt acgggccatg aaaaccttcc ttcgaattaa aagattacga 2611741 atgtaaaaga atctaccttt tagaatttta cttgcacttc taatattttt caattcttta 2611801 gggataaagt tgggaaaaga ttgcaaaata aaaacctttt cgctcaatga aaaggttttt 2611861 accatgtttc tatttttgta aatttctgag tgcattccga tattccgtat catttattac 2611921 tttatatgat ttgacagttg ccttcgacaa accttgtgct gagacggccg gtttttccgg 2611981 agctgttttc gctttatcat gtggtttatg tgccagcttg tgccccattc cagtggcatt 2612041 catacaaaat gacaggcaga cgagcagcac gctaaggata aaagaaatga agaagagatc 2612101 atgataagca gtcatcatag aatcctgtac cgaaccgctt tgtctggcag catctttttt 2612161 cgtgaaaaag ccgatgagaa tgggaactcc catatagaca aacaatctta aaaactgaac 2612221 agctgtcatt ctcttgacca aatcaggcag cgggcctccc atggcagctc ccatcagccc 2612281 tgcggcgact gtcaggcctg ttcccgctgc aagcatgata aacagtgccg cgaacatata 2612341 aagagatgat cgatcctgta tatgcagcca ttgaaaattc acaaaaacga gaatgagtcc 2612401 gccgataata ccgagcatcc ctggtccgac tttatcgtat aacagagcgc tcaaaatggc 2612461 cgcgatcgcc actccgatta aaagagtcaa gcttaaaaga atgagatgct cctgagaaat 2612521 atcatacatt tgacggagca agccttgaaa agcagaaagg ctgacagcta ccgttatcgt 2612581 ccctgcagct atgatcaata agccgagcac cggttttggc agcagcatca gtttaataga 2612641 tatgaagggg tttttcactt tatattccac aatcaataga ccaatgagca aacataacgt 2612701 caccccgaaa ccaatccata cataacccga tgacagcccc catttttgca gaaaaatgaa 2612761 tgaaaccgct gaggctgcgg caaggaagac agataaaaga attcccgcac gatcaagcgg 2612821 ctgttcttga tccgccgctc cgtgatgctc atcatgaaga aagaaatagc tcaccgcgac 2612881 accgatcagg gacaaggtgc caaagatgaa aaacagccat ctccaatgcc cgcagcttgt 2612941 tgcaatggtt cccaggattg taccgatgat aacagaacca tagaatcccc cgatcagcac 2613001 aagcagtgca tagttcctgc gttcaatcgg gaatgacagt acaagcattg gaatcataat 2613061 catcagcatg acgcctgttg ccgccccttg taaaaagcgc cctgccgcca tcaatgcaat 2613121 atcgcctgaa catgcgatga gcagtgagcc tagtataaag acaggtaatg aagccagata 2613181 gacgggacga gcaccgaatt ttttcctcag cagcggtcct gccggaacta acaaggcaaa 2613241 ggccatattg ccgatcaata tcggatttac tgatgtaaag acacttgttc caaccgtttt 2613301 ctgaacaagg ccttgaactg acgacaatgc cgtgttagac atcaatcccg gcccgaccgc 2613361 taagacggcg agcaaagaaa tcacccaata gtgttttgtc ttcatgttgt catcccttcc 2613421 tatatgaata catgcgaaac acatcatttt ttgaaaacaa aagaagctaa tagattttgc 2613481 ataccattag ctttcattct aatattctcc ctttcagggg aaatgatatt attttattat 2613541 aattatgtga atgaatgagc atataatcaa atattatttc aaatcgattg tgttttgtca 2613601 atggagtaaa tttcaagcac aacatagaaa gcttgaaagc ttttccccga tattgtgtct 2613661 agaactgcac ttatgaatcc ctgctcgttc cctcaagcga attaaagcag gccgttttaa 2613721 tcctttcaat ccactattcc aactaataaa ctcaaataag ttggtgataa gacaacattt 2613781 tacccccaca tttttttgtg ttcactgggc gtttgccgcc tctaaattgt atatgggtaa 2613841 ataccatgaa ttaacctatg aaataccaat gtaagggagg caaaaacgaa tggaactgta 2613901 tgagtgtatc caagacattt ttggcggctt gaaaaatcca tcggttaaag atttagcaac 2613961 gtctttaaaa caaattccaa acgcagcaaa attgagtcaa ccgtatatta aggaaccaga 2614021 ccagtacgct tacggccgaa atgccatcta tcgaaataat gaattggaaa ttatcgtgat 2614081 taacattccg ccaaacaagg agacaacagt acacgatcat ggtcaatcca ttggttgtgc 2614141 aatggtgtta gaaggaaagc ttcttaattc tatttatcgt tcaaccggcg aacacgcaga 2614201 actctccaat tcatactttg tccacgaagg agaatgcctt atttcaacca aaggtttaat 2614261 tcacaaaatg tccaatccaa catctgaacg aatggtgtct cttcatgtct actcccctcc 2614321 tttggaagac atgacggtct ttgaggaaca aaaggaggta ttggaaaatt catgattgac 2614381 agataaactg ctcactttga cttcactcaa ctggaggatt cagagaatga aaccttttcc 2614441 tcaaaacaaa aaaaccctta tcgaataagg gtttaaaggt atggagccaa gggggctcga 2614501 acccctgacc tctacgctgc cagcgtagcg ctctcccagc tgagctatgg ccccgtatgt 2614561 aacgtcatgt ttattataga tgattttatt ttgaaaaaca agctgtttcc tcttgaattg 2614621 acagaaaaaa taaggctcgg aaaagagcct tatttttcga cttacatcat gatcaaaagt 2614681 aaaatcacac cgagaataat tcgatagatt gcaaatggga caagtttgat tttgttaatc 2614741 agccttaaga agaaacggac gacaaacagt gcgaccacaa aggcacagat aaagccgacg 2614801 atgaaaaacg gcatcagatc cgaacttaag ctgtcccaat gcttcacgag gcttagaaag 2614861 ctggctccca tcatgatcgg catcgccata ataaacgtaa agtcggctgc agctcggtgg 2614921 tttaatccga gaataacacc gccggaaatg gttgaacccg aacgcgagaa accaggccaa 2614981 agggaaagac attggaataa gccgacggct atcgcctgtt tataggaaat gcggtcgagt 2615041 gtgtctgtcg ctgttttccg tttattgacc cagtcagcaa aaagcatgag gattgccccg 2615101 gcaattaaac cgatggccac agttttaacg gaaaataaat attcatcaat gtaatcttca 2615161 aacaaaaagc cgagaacagc tgcaggcacg agtccgacgg caatttgggc aatgcttaat 2615221 ttatgtccct gctcctggtc gcttgtaata ttttttttca agcccagtaa atttaaaatt 2615281 cggtctttaa acacgatagc tactgctaaa atggagccta gctgaataac caccttgaat 2615341 gagttagcag cttcttctga catcagatta cttgatttta gccagatgtc gtctactatg 2615401 atcatatgtc ctgtcgaaga aaccggcgcg tactctgtta atccttctac gattcctaaa 2615461 atggcggcta caaacaattc ccatagagtc atgattttga ttctccccat tagacattta 2615521 tttttttaca taacgggagc ttcccataaa tggaaagccc gtcttatata actataaacg 2615581 aaaatcacac tttatgcccc ggcgtatttt catttttttc ttcatcgtat aaatgtgact 2615641 gcattttaaa ccagtcaaat aaatgtgtcg taatgacttt ggcaaccgca tagccgggaa 2615701 tcgcaagaat gattccaaca acgccaaaca gcttgccggc tgttaacagc agaaaaataa 2615761 tcgtaatcgg atggatgtga aggttttttc ccataatttg cggagagatc agcttccctt 2615821 caatcagctg aacaatcgtc caaacgatca ccagcttaag cagcatgagc ggcgatgtca 2615881 ctatggcaat gataatcgca ggcgtaatgg caatcgttgg ccctaaatat ggaacgatgc 2615941 ttgtgcaagc cgcaatgact gcaagcaatg aagcataatc cagcccgata atcaaataac 2616001 cgataaacag caaaaacccg atacagaagc tgacaatgat ctggcctctg atataagagc 2616061 ttaaccgatg attcatttcg cttaagactg tatatgtctg ttctttcaat cgagtcggca 2616121 caaacttcag tatgtagacc ggtaattttc ttccgtcttt tagcaaataa aatagaataa 2616181 acggaaccgt gacgatcgaa atgataatct cagtcagtgc gccgataaaa ttcccaacac 2616241 cggtaaaggt gctgttcacg atcgtcgctg cctgatccga aacctttgta gcaagatcag 2616301 atatattaat gttcatcgtt tgctgggcct gattgacgaa gttgctgcca atcagctgtt 2616361 tcgtctgatt ttctacgacg tccacatatc tcgggatatt gtcaatcaaa ctcataattt 2616421 gttcttttaa gaagggaatg atcgacacga tcgtgatcgt gatcagcccg ataaccaata 2616481 ggtatagcag caatatagaa tagattcttc ttattcttct tctctccaga aaatcgacga 2616541 ctgggtttaa cagataaaaa acaatgcctg tcaaaataat cggaagtgat atcgttttga 2616601 gcagaacaat aatcggggtg aaaataaatg atgtttttgt aaatactaga atatttaaac 2616661 caatcagcag cagcacaagc aaaaataaaa caaacttatt atccaagaag aatcgcttga 2616721 atctgccgct ccatgtttgc aacgtctcca ctatcgttcc tccgtcatac atagtttaat 2616781 taaattgtac actatcgtcc ctataatgaa aaataaaaac cgttaattgc tggaaaagct 2616841 ttctcggttt taacattcta tttatatcta tcatgtgatt ttgttctttt taagctataa 2616901 tttagctata tcatgcaaaa ggagcgatac gagtgatacg ttttgcaata ataggaacca 2616961 actggattac agaccgcttt cttgagtcag cagcggatat cgaagatttt cagctgactg 2617021 ctgtttattc aagatcggct gaacgcgctg gcgagtttgc tgctaaacac aacgctgcgc 2617081 atgccttctc agaccttcag gaaatggcgg cgagcgattg ctttgatgcc gtatacatag 2617141 cgagcccgaa cgctcttcac aaggaacaag ccgttctctt tatgaaccat ggcaagcatg 2617201 tgctttgtga gaagccgttt gcttcgaata caaaagaaac agaagagatg atctcagcgg 2617261 ctaaggcaaa cggcgttgtt ctcatggaag caatgaagac cactttcctg ccgaatttca 2617321 aagaactgaa aaaacacctg cataaaatcg gcactgtccg cagatttacc gcaagctact 2617381 gccagtattc ctcacgatat gacgcgttca gaagcggaac tgttttgaat gcgtttcagc 2617441 ctgagctttc caatgggtca ttaatggata ttggcgtcta ttgtatttat ccggctgttg 2617501 tgttgtttgg cgcgccgaag gatgtaaaag caaacggata tgctttatcc tccggagtgg 2617561 acggagaagg aactgtcatt ctgtcttacg acgggttcga agctgttctg atgcattcca 2617621 aaatctctac ttcctatgcc ccggctgaaa tccagggtga agacgggacg attgtaatcg 2617681 atacgattca ccggcctgaa cgtgttgaaa tccgctaccg ggacggccgc cttgaaaaca 2617741 tcgcgatccc tgatcctaaa ccggcgatgt tctatgaagc agaagaattt gtcacgctta 2617801 taaaagagaa taagctggaa tctgaagaaa atacatttga acggtctttg accaccgcaa 2617861 aaattatgga agaagcaaga aagcaaatgg ggattgtata ccctgctgat caagcttaaa 2617921 aaaatccgcc cgcgtgcaaa tgccgcggcg gattttttat tagacaatcg gagaagatgc 2617981 cttccttttt aaaagcacct gttgctcata ttctttgatg tcataaagcc atgcctcttt 2618041 taccggaacg cccatttgct cacagtagga atcccagatg gctccgaaag gatatgtttt 2618101 gaattcctcc atcagggcca gcctttctgt atagcggccc tcttcctgca attgttttaa 2618161 atatccgttc gggagaagca gggcatacaa taaagctttg atcatatttc tcgttccgat 2618221 ggtccaggcg gctacacggt taatgctggc atcgaaaaaa tccagaccga tggctacctt 2618281 ctcaagagca tgatttcgta caatttcaag agcgatttct ctcaattcat catccaaaac 2618341 cactacatgg tcgctatccc aacgaacagg ccgcgatacg tgcaaggcaa gcttgtctgt 2618401 gtaaagcagc atggacgaga tcttgtttga taccgtctca gtcggatgga aatggcctgt 2618461 atcaagtaaa caaagcttat gattcgtcaa agcataagct aaataaaatt catgagatcc 2618521 gacaacatat gattcggagc caagcccgaa cagcttgctc tcgattgaat caagattatg 2618581 ttgttcactg atctcctctg agaagatccg atccagtgat tcttttagtc ttttacgcgg 2618641 tgtcagccta tcactcggga tatccttata gccgtcggga atccaaatat tcgtcaagca 2618701 aggtgttcct aattctttcc cgaagtattc cccgatacgg cggcaagcga tgcaatgcct 2618761 gatccaaaat tctctgatgt ccggatcagg gtgtgaaagg gtgagtccgt cagccgcttt 2618821 ctcatgcgaa aacaaggttg gattaaaatc taaaccgaga ccaaggtttt ttgcccattt 2618881 cacccagttt tcaaaatgct gcggcttcaa ttcgtcacgt tctaccgctt ccctgtttgt 2618941 ttctgcgtat atcgcatgca ggtttacgcg gtgctttcca ggaatgagag aaagagcctt 2619001 ctccaaatct cttcttaatt cttcaggagt ttgcgctttt ccgggataat tgccggtcac 2619061 gtcaattccg cctgaaagct cgcccttatt tacttcaaag ccttcaatgt cgtcaccctg 2619121 ccagcagtgg atcgaaatgg gcacttgctc taattgccga agcgcctctt caacatcaat 2619181 tccccatttt tcatatgcct gttttgcact gtcataattg gcttttatgg tcatacggct 2619241 ctctcccttt atcagttttt caatccaaat aaaaaacttc ctttagatct atcgcaacag 2619301 gactgaaatc cgaatttgtt ttcattaatg gcgccatcga tttccaccat ctttggcaaa 2619361 cttccgtgtc cgccatcttt ctccatttct cttcatcctc tatttctaaa tatgcaaaaa 2619421 gcctgcctgt ttcctcgtct agaaaaatgg aataatggtg tgctccatga gctttgagtg 2619481 cttctgccat ctcaggccaa atgtcatcat gccgctgttt gtattcttcg tacttgtctt 2619541 gatggacaaa catgatactg gcttttcttt tcaaaccttt tcacctcttc atcatttaga 2619601 tagcgctttc aaaacagttt gctgaaatga ctgaatgatc gtgcttctat caatgtcttt 2619661 aggtgtaaac actttgatcg gaaaggaatt tctgacgact tgccgggctt cttttatgtc 2619721 tttgacttct ttggcagcaa tcatttgcat caaaagattt ccggtggcag ttgcctctat 2619781 cggccctgca tataccgctt ttccactcat gtctgccgtt aattgattta agaaatcatt 2619841 ccgggctccg ccgccgatga tatgaaattg ctcgatcggt ttttctgtga ttgtttcgag 2619901 ctctttgatg gctatcgcat agatgatggc taaattgctg tagatgcagc aggcaagttc 2619961 gcctgcagta cggggaatct tttggcgggt ttgtctgcaa taatgttgta tttcctttat 2620021 catgttttct ggattcagga aacgtttatc atttaagttt ataaattgct ggaatggttc 2620081 tgtttttttg gcttcttctg caagctgctg aaaagaataa tctgcttgta gctgctgttt 2620141 gacttcttgt atcacccaca tgccgataat gtttttgaga aagcgaatgg tgttgtttgc 2620201 gccgcgttca tttgtatagt tgttttctaa agcaagatca gttattatcg gtgttttgtt 2620261 ttcaaccccg attaacgacc atgttccgct gctgatatac gcccagccat catttacgcc 2620321 tggcgccgca atgacggccg aggccgtatc atgtgttgcg actgtcatca ccttgcacgc 2620381 cgggagatca taatccggga accactcatt tcttagcttc ccgagttcac accccggttc 2620441 agtgagcggc gcaaattgct gttccagaac agacacggct tcaagcaatt caggatcaag 2620501 atttcccgtt gagacgttta aaagctgtgt tgtggacacg tttgtgattt ccgttacagc 2620561 ttttccggtt aaacaatagc ctaaataatc aggaatcatc ataattttgt ctgtcttttt 2620621 cagcagctca cggtcttctt caaacaattg atagatcgtg ttgaaaggct gaaattgtat 2620681 tcctgttttt tgataaattg cggcttttga gagggtatgt tccagtttgt ctattgtgtg 2620741 atctgttctt ctatcacggt aggagattgc ttcccgcaac cgatcgcctt tttcgtccag 2620801 taagacataa tcgactgccc atgtatcaat gcctacggtg cagtgttcat acccaagcgt 2620861 ctttactttt tgcagtcctt gcaggatttg ttttagcaaa tgatcaatat cccataagca 2620921 atgcccgtct ctttgactga aaccgttagc gaacctgtga atctcttgta tgtcaagctt 2620981 cccttcattc agttcaccta ccatgattct cccgcttgat gcgcctacat caatggcagt 2621041 ataaatcatc ctttcaccct ctcttcgaaa gaggaacagc tgtcaccttc acctttttgt 2621101 cctcaagagc ttttaccgat gccggatcaa gtccagaatc cgtaataagg cggctgacat 2621161 cttgcagcga ggcgatatgt gaaaactcgc ggttccccca tttgcttgaa tcggccatca 2621221 aaatggtctg gtccgacctt tcgatcatcc gttttttgag cagcgcctgc cactcatttg 2621281 aatcactcat cccgttgtgt acgtcaaatc ccttacatga cagaaaggtt ttattgacat 2621341 gataggtctc aagtgaacgc tctgctaacg ggccggcaaa tgataatgat ttttccagca 2621401 aaatgccgcc tgttgaaatg actgatatgt tttctttatt gctgagttca atagctgctt 2621461 tcattgagtt tgtaatcacg gtgagctcaa tgtcagggag tatttttgcc atgtaccaag 2621521 cggttgtgct tgcatcgaga atgattcggt ctccgctttt tacatatttg gccgcttcgt 2621581 gagcgatggc ttttttttcg atgacattcg tgatttcccg ttcagaaaaa tgaatttctg 2621641 attccttctg ctgaatactg accgctcctc cgtggctccg gctcagttta tgttcttttt 2621701 caagcttttc aagatcacgc cgaatggttt cctctgtgac tgaaaaaatg tcacttaatt 2621761 cggaaacgcg gatgcttgaa cgcatattta ctatttccac tattttttgc tgccgttctg 2621821 ctactagcat cggtaacgcc cttcctcata tcgtagtccg tcttatattt ttatcatagc 2621881 atatatctaa cgcgtaaaag cagcagggac gccgccgtct accgtgatca tgcagcccgt 2621941 tgttttttcg gctttggaag aagcgaagaa tgcaatggct tcggcaatat cctccgggta 2622001 aatattgacg agcaatgctg tccgtttccg gtaatgttcc tccagctgat ccggttcaat 2622061 cccgtacgcc gcggctcgtt cctcacgcca gcttgaaccc cagattgccg atccttgaag 2622121 aactgcatca ggcaaaacgg agttgaccct aatgccgaat tctccgcctt ctgctgcgat 2622181 gcatcttgct aaatgggttt caagcgcctt aacagagctg taggcagagg cgttttttcc 2622241 cgcataaact gaatttttcg atccgacaaa taccatgctt ccgcctctat tttgatgttt 2622301 catctgttta aacgcttcac gggctacaag gaaatagcct gttcctaaaa cattcatatt 2622361 aagattccat tcttttagac ttgtttcgtc aaatgggctt gatgtggcca gcccggcatt 2622421 attgacgacg atatcaatgc cgccgtaagc aagcgccgct cgttcaaaag ctgactgtac 2622481 gtcttcctcc tttgtcacat ccattttgac agccattgcc cgtccttttc cgtatgcatc 2622541 gtttatttcc ccggcaattt tctgtgcgcc ttctatattc agatcagcta cgatcacgtg 2622601 ccctccctca gctgcaaatc ggcggcatgc cgcactgccg attccgccgg ctcctccagt 2622661 tatcagcgct acttttcggg aaaattctgc ttccggcggg gccagcgtga gtttatatag 2622721 ttcgagcggc caatattcga catggtagga ctcattttca tgtaaagaaa caaattgccc 2622781 cagagcggtt gctcctttca ttacggcgat ggccctccga tataaagccc cgcttacttt 2622841 agacatcgca taactttttc ctgtattcac cattccgatt ccaggaatca atatcacccg 2622901 cggggcggat tcaaagattt gatccccatc ctgctgattg cgtgtaaagt aagcctgata 2622961 ctctgatgta aaggtctcga ctcctgactt gatcagatct gcaagcttgt gcacatcttg 2623021 agtttccgga ttccaatcaa tgtacagcgg aacccgtttt gtgtgaacaa ggtgatccgg 2623081 gcatgccgca ccgatttgcg aaagtgctgg cgcttggaca ctgtttacaa attccaagac 2623141 atcgtcatga tcatcatagg aaaggatcat tttcttttct tcacttactg ctcctctgat 2623201 cacaggcatg atgcctgcca agatttgttt tcttttatcc tccggcagcg gctgatacct 2623261 tttgcctccg aatacctcat gctgattgat acgatcgtta atatactgct cggcttcttg 2623321 aatgatggat atcgtttttt gataacatgt ttcagacgtc tctccccaag tgactaagcc 2623381 gtgtttctcc attaatacaa gctcggcgtg ggggttgttt gctacgcctt cagcgatcat 2623441 tttagacaaa gtaaatccag gacggacgta tggcacccat acaaaccgat ttccgtaaat 2623501 gtcttcagcg atttgttttc cattatccgc acagcatatg ctgataatcg catctggatg 2623561 ggtatggtca acatgtttgt atggcagaaa agcgtgtaat agcgtttcaa ttgaagggcg 2623621 gggatgtttg ctgtctatca tacaatgaga caggtagtct accatttctt catcgggcat 2623681 ttggtccctt ttaatcagcg ggcggatatc atctaatttc aaaccggaaa agttatgcgc 2623741 tttcattgtt gccaaatccg atccgcttcc ttttacccac atgacttcta tttcacggcc 2623801 tctaaaatcc ttttccgttg ttttcataga tgtattcccc ccgccccagt tgcagacagt 2623861 gcggtctgac ccgatcagat tggacctgta caccaattcc tctacacctt taggtagctg 2623921 tgcagctcgc tctgaatccc atatatgttt caccatattt gatattcctc catacccttt 2623981 tatttgtatc cgttttcatt atatatgatt tctgtttgtt tttgaatcgt ttttgtttat 2624041 ttttgctttt taacaaaaaa agaaagcagc agatatgccg ctttctcgtt tcattatgat 2624101 tctattttaa atttcttcgt aatgtcctga agttcttccg ccatgtttgc caacgtttcc 2624161 gctgaagagc tgatttcttc catggacgca agctgttctt ccgccgaagc tgcgatatcc 2624221 tgaatgcctg ctgagctttc tttcgccact gcagaaatat cttcaacagc acttgacact 2624281 tcctgtgatc cggctgacag ttgttcaacc gtcgcgttca agttttgcaa ttcgccggaa 2624341 atttgggttg tcatctcata gatttgttta aagctttccg ctgtttgatc cgtaatctgc 2624401 aagccttctt tcacttcatg attcacggat tggaacattg aaagtgaggt gctgatttcc 2624461 ctgacaatct cttgaattaa tccttcaatt tccttggcgg agtctgctga ttgtacagca 2624521 agttttctaa cctcttccgc aactactgag aaacctcttc cgtattctcc cgctcttgcc 2624581 gcctcaatcg cagcatttaa tgcaagcagg ttggtttgat cagcaatgcc gttaatcaca 2624641 ttcaagatgc ttgtgatgtc ttgcgatttt gtttcaaggc ccttcacaac cgcttccgct 2624701 ttttgaacgg attggtcaat tgttttcatc tggccgactg tatgctccac cagcttttct 2624761 ccgctgcccg ctgcctcaga ggactgaatc gatgatttcg taatggttga agaggcttga 2624821 gccacttttg aaatcccctc gttcatttga gaaagatgat ttgagcttgt ttccagtttc 2624881 tcgctttgtg cctcgttgcc atctgagaac tgttcgatgg caagtgtaat atgttcagtt 2624941 gccttgcttg tttgggctgc gcttgctgtc agctcctcag aagatgaagc gacgttttct 2625001 acagacgttt gaataacgcc tattacagaa cgcaatgatg cagacatttc attaaagctt 2625061 tcgccaagct ggccaaactc gtttttcgag tgaatgtcaa tgacttctgt gagatctccg 2625121 ctgctgattt ttgcagacgt tgagacaagt tttcttaacg gcttggtgat ggcacggata 2625181 atatagagta tgagtatgcc gccgattact attgacacgc atagaatgat aaccgcagtg 2625241 ttcagcaccg ggcttgaagc atcttgcaat tcactgacaa aatatgtgcc cgcgattttc 2625301 cagccagtca gtttatttgt cgtaaaggcc attttctttt ctttgccttc gaatgtatat 2625361 tcaaatgagc cttctttttt ggaatatact tggtttgtcc aatcgccgga accggttgtc 2625421 cccggcttaa tggtcggatg ggcgatatat tttttgttgc ctgtcgtaat aaatgcaaag 2625481 ccttcttttc cgattttgat tctttttgat gcagtaagca cttcatccag gtttaaatct 2625541 agcgctataa cccctgaacc gtcttttaat tgttttgaaa ttgtgacaac gatatctcct 2625601 gtcgcttcat cggtatacgg ttctgagaaa acagcttgtc ctttttccgc aaccgcctgt 2625661 ttgtaccagt cacgtcctgt cggatcgaaa cctttcggaa caccgctatc cggatattta 2625721 taaagcttct tatcttctga ggcagcatag attgcgccta catcgtcgtt aagtgtcgtg 2625781 tactgcttaa atttctcttt cagtaatgtt ttgtttttgc ctaacaatat gtctttatcg 2625841 actgtctcac tataataatc tattgctttt actttatctt ctaatttatt ttgcagcgta 2625901 ctgtttagtt cttcaacatt tcccttcgca ctgcttatga gctctctgtc taacgcgttc 2625961 caagctgatt gataactgaa atatgctaaa accccaaccg gcaaaataag cactgccaga 2626021 aacgcagcga ttagcggttt gctgatcgat ggctgtttga tccattgtat gaattttccc 2626081 attctcgttg actcctcctt taagataaat ctaatatcgt caaactagga taaaaggttt 2626141 aataaaaaaa ctaaaaaaaa cacccaagcg caacaagctt gggtgttaag gcttattatt 2626201 caattttaaa tcgtttggtc atatcccgaa gctcttccgc catagaggaa agggtctctg 2626261 cagacgagct gatttcttcc atggaagcta gctgctcttc agctgacgcc gcgatatctt 2626321 gtatatgcgc tgagctttct tttgaaatcg atgcaatgtg ctcagacgct cccgaaactt 2626381 cttcggagct ggcagaaagc tgctgaaccg tcgcactcat attttgcagt tcgccggcga 2626441 tttggttcgt catttcagaa atgcgtttga agctcatttc tgttttatct gtgatgtcaa 2626501 gtcctgtctg cacctcttga ttgacagatt ggaacatgcc gagtgatgta ttgatttcct 2626561 tcacaatttc gatgattaat ccttcaatct cttttgctga atctgctgac tgtactgcca 2626621 gttttcttac ttcttccgct acaacggaga agccgcggcc gtactcgcct gcgcgcgctg 2626681 cttcaattgc tgcgtttaag gcaagcaggt tcgtctggtc tgcgatgccg ttgatcacac 2626741 gcaaaatgtt tgtaatatct ttcgatttcg tttccaatcc gcgtacgact tgctccgctt 2626801 ctttaacgga cttgtcaatg acattcattt ggccgacggt ttgatgaaca agcttgccgc 2626861 cttcacttgc aatttctgtc gattgaacag atgaatcagt gatcacttca gaagcttgag 2626921 ccatattcgt caacccgtca ttcatttgat aaatgtgctc tgctgccgtt tcaatgtttt 2626981 cgttttgttt ttcattgccg ttagaaaatt gttcaatcgc caatgtaatg tgctctgttg 2627041 ccttgctcgt ttgcgcagct gatgcagtca gctcctcaga ggaagcggca acattgtcta 2627101 ccgaatcctg gatggcgtgt atgagagaac gaagtgacga cgccatattg ttaaagcttt 2627161 tgccgagctc gcccaattca tcttttgaac ggatatcaat ggtttccgtc aaatctccct 2627221 cgctgatccg cttagaggaa ccgacaagct gtttcagcgg tgttgtaatc gaccgaatga 2627281 tcaatgtcat gacgataatc cctatgataa tagctgcggc caagacaatt aaagcaaggt 2627341 gaaggacagg ctgggctgcc tcatggattt catccaaata catggtgccg ccgatcttcc 2627401 atcccgtcaa cttgtttgtg tcaaaggcca tttttttctt atcgccatcc atggtgtatt 2627461 gaaaatcgcc tttatcagca ctcaacatct tatcgagcca gtcgcctttt aattcagttc 2627521 ctgattgttc attagggtgt gcgacaactt ttttgtcctt cgtcatgata aatgcgtagc 2627581 cttgtgtgcc gatgttgact tttttggttg ttttcagcag attttcaatc gtcatgttga 2627641 ttgcgataac gcctgaacca tcttttgtct gctgggcgat tgtcacaacc atcgtatttg 2627701 tcgacgcggt tttataaggg tctgtgatca cgactttccc tttatttgca accgcttttt 2627761 tgtaccagtc gcgttcaacc ggattatagc cgcttggcat cggaagatcc ggatagcggg 2627821 taaagtgccc ttttgtgtca cttgtataaa tggattctac atccttgtta atgctgatat 2627881 attgtgagaa tttctctgca atgcttgcat tgctttttgc attgtatttc tcttttgtca 2627941 gccattcgct gaaataatca gcactgtttt ctttttcgcc gatgctggtg ttaatgattt 2628001 cgtttaattg ctgtacattt tccaatgcgc tccccatcat ctgtctgtcg agtgagctgc 2628061 tagccgattg atacgcaaag atcgccaata tgacaaccgg tatgatgagg atcgacagaa 2628121 aggaaacgag aagcttccgt gtaattgatc tttgttttat gagttggagt atttttttca 2628181 tcattcattt ctcctttttt atgctaccct tcatatcggc tggaaatggg taaatatata 2628241 cagcaaaaaa gaagaaattt aacaaaagta actaatttcc cataaataaa tagtatttta 2628301 gacctattat ttgtctactt taaattgttt tgtcagatca cggagttctt cagacattct 2628361 ttcaagcgtc agtgcagatg aactaatctc ctccatggat gccagctgtt cctcagctga 2628421 agcggcgata tcttggatgc catccgagct ttccttagaa atggcagtga tatcatttga 2628481 agctgcggaa atttcttgag ctcccgctga cagctcctca accgtcgcat tcatgttttg 2628541 cagctcggaa gcaatttgat tggtcatttg cgatatatgt ttgaagctct gtttagtttc 2628601 atccgtcatg acaagccctg tttcaacttc tttgtttacg gactgaagca cgttcagtga 2628661 tgtgtgaatt tcttttacta tttcactgat cagcgattca atttcttttg ctgagtcagc 2628721 cgactgtacc gcgagctttc tcacttcctc agcgacgact gagaagcccc ggccgtattc 2628781 acccgctctg gcagcttcaa tggcggcatt taaagccaaa agattggttt gatccgcaat 2628841 gccgttgatg acacgcaaaa tattcgtgat atcctttgat ttgatctcca gccctttcac 2628901 cacttgttcc gctgctttta cggaatggtc aattgtgttc atttggccgg ctgttttctg 2628961 gacgagtgtc tcccctttgc ttgacacttc ggttgaatct gcggatgttt ctgtaatcac 2629021 tgctgcagcc cgcgccagct ctgccaatcc gtcattcatt tcattaattt gttcggttgt 2629081 cgtttctatt ttctcgcttt ggctttcact gccgtttgaa aattgctcga tagccatcgt 2629141 aatgtgctca gtggctctgc ttgtctggtc tgccgatgca gtcagctctt cagacgagga 2629201 ggcaacgtgt tctactgagt ctttgatccc gtgaatgagc gagcgaagcg agtgtgccat 2629261 atgattgaag ctctcactca gaacgccgag ttcatctttt gaattgattt caatcgtttc 2629321 ggttagatcg ccttcactaa ttttttcagc ggatgcgaca atgcgtctca atggctttgt 2629381 gatggatcga atcacaaaat aaatcgccgt cattccagct ccgatggcaa tcgccagaac 2629441 gattgaagcc atgatcagaa ccctgcttgc agcatcgtga atctcgtttg catacatcgt 2629501 gccgctgatt ttccagcctg ttgtttggct tgttgcaaat gccatttttt tctttttgcc 2629561 tttgtacgta tattcaaagt ccccgctttt atccttgtag agcttatcaa cccagtcccc 2629621 ttttagctct gttcccgctt tttctccgga gtaggcgatg actttcttgt tttggctcaa 2629681 aataaaagca tagccttctt ttccgatatt gattcctttc gcggtagtga ctaagtcatc 2629741 aattttcata tcaatggcga caacgcctga cccatccacc gtttgacggg cgatggtgac 2629801 gaccattttt cctgatgaaa tcgattcata aggctcagtg acaattgttt tgcctttatt 2629861 ggccattgct tctttgtacc aatctcgttc caaagcatta aagtcgcttg gcatgtcagc 2629921 gtacggataa cgtgtgaagt ccccgtcttt gccgcttgaa aataccgcag cgacattatc 2629981 attcatttgg ataaattgtt taaattcctg tttcagctct gttttctttt tatcctgaaa 2630041 tttttctgct gtagcccaat cgctgaaata tgcgaggctt ttttcagtag tgctgatttt 2630101 atcatcaatg atgtgatcta atatctgaac attttccttt gcgctttgcg tcatctgtac 2630161 atcaagtgag gcaactgctg attgataagc gctaaccgaa agggcggtta tcggaacaat 2630221 taagatcagc aggaaagaaa taataagtct ccttgcaatt gatgatctgc gaatagtggt 2630281 gagtgttttt ttcatttcct tttgaacctt ctttcaataa tttacaaatt atatcggcgg 2630341 atcttccttt aaattacatt gaaaatggag gaaaaaatga aaaatagttc taaattcacc 2630401 tgttaaacta ggactttatt attgtttacc atataaaaaa acagcgcttt gatagcgctg 2630461 tttttcggtt tttactcgat tttaaattgt ttcgtcagat cgcgaagctc ttctgccatc 2630521 tgcgcaagag tcgtcgctga ggaactgatt tcttccatgg aagcaagctg ttcttcagct 2630581 gatgcggcaa tgtcctggat gcttgccgag ctttctttcg acacgtctgc aatgccgctg 2630641 actgctgctg aaacatgctg tgaacggtct gacagctgct cgacggtgga attcatcgtc 2630701 tgcagcttgc ccgcgatttc gtttgtcatg ctgaaaatgc tctggaagct ttcttttgta 2630761 ttgtctgtga caacaagtcc ggactgtact tcctgattga cctctttaaa catgtgaaga 2630821 gaggtgtcga tttctgcgac gatttcttgg atcagctttt cgatttcttt cgctgaatcg 2630881 gctgattgga cagccagctt gcgcacctcc tccgctacga cagagaagcc gcgtcctgac 2630941 tctccggcac gcgccgcttc aatggctgca tttagtgcaa gcagatttgt ttggtcagcg 2631001 attccgttga tgactctcaa aatgcttgtg atgtcttttg attttccttc taagcctttg 2631061 acaacagctt cagcctgctg aacagattga ttaatcgagt tcatttgtcc gactgtctgc 2631121 tgcacaaact tctcacccgt tccggcgatt tccgttgatt ggatagatgc ctttgtaata 2631181 tctgacgatg tttgtgagac ttgctggagt ccttcattca ttaagttcag ctgatgagag 2631241 ctggattcaa ccttttcgct ttgctcctcg tttccgtttg agaactgctc aatcgccatc 2631301 gtaatatgct cggtggcttt actcgtctgc ccggcagatg cggtaagctg ttcggaagat 2631361 gcggccacat tgttcaccga gtcctgaata gcgctgatca gagagcggag agattgtccc 2631421 atttcattga agctttcccc aagctctcca agctcatcct ttgaatggat ttcgatcgtt 2631481 tcggtcagat cccccctgct gatcgttttc gatgattgaa caagacgttt taacggtttt 2631541 gtaatcgaac gaacgataaa cagaattaaa attccgcctg ccacaatgga agcaatcagc 2631601 acaatcattc ctgttgtcag cacagacttt gaggcatcct taatttcatc catatacatt 2631661 gtgccggcta ttttccaacc agtcagttcg tttgtagtat aggtcatctt tttatcttcg 2631721 ttattaagag tatactggag ttcaccgctg tcattcgcat acattttggc tacccagtcg 2631781 cctgaaagct tttctccagc cttatggttc ttgtgggcga cataggtttt gttttttgtt 2631841 gcaatgaaag cataaccttc ttttccgacc ttgatttgtt tcatttgttc taacaattta 2631901 tcaatggtaa tatccatggc gacaacgcca gatccgtcct tcagctcctg tgcaatggta 2631961 atgaccatgc ttccgtcact cgcagccacg taaggatctg tcacgacaat ttcaccgccg 2632021 gccttcatcg catcctggta ccaaggccgt tgtctcgggt cgtatccttc cggcaatttt 2632081 tcttttggcg cttgtacata agtgccgtta tctgcgcccc cataaattct ggctactcct 2632141 tgattaatag atacatattg tgaaaattta gctttgatct cttcttgatt tgatttccct 2632201 ttgaatgcgg atcttttaag agattcactg aaaaaggtga ctgctttcgc tttttctccc 2632261 agatcatttg taacagttgt attaaatgta tcgacactgt ttttcgcatt tcccataatt 2632321 tcctgatcca gctttccgct ggcgcttcgg taagagctaa attctaatat aagaataggg 2632381 ataatgagaa tcgcaataaa tgagacgatt aatttctttg aaatagacgg tttcttcagc 2632441 caattgataa aagtcttcat gtcacttgct ccttcaggtt tgatacagta tatatcggct 2632501 gcttaaaaaa gttttaaaat aaaaaatgga agaagttctt tttggctgtc ttctgccttt 2632561 ttaactttca ttgcccaagc tctttgcata tcttataaaa aacaaggggg gctaaacatg 2632621 attattgtat caggacaatt gctccgtccc caggatattg aaaattggca gattgatcaa 2632681 gatctgaatc cgctcttaaa agagatgatt gagacgcctg ttcagtttga ttatcattca 2632741 attgctgaac tgatgtttga gcttaaactg cggatgaata ttgtagcagc ggcaaagacg 2632801 ctgcacaaaa gcggggcgaa gtttgccact tttttaaaaa catacgggaa tacaacgtat 2632861 tggagggttt caccggaggg cgccttggag ctgaaataca gaatgccgcc ttcaaaagcg 2632921 attcgggaca ttgcagagaa cggcccgttt tatgcgtttg aatgcgcaac cgcaatcgtt 2632981 atcatttatt acttggcctt aatcgataca atcggagaag ataaattcaa tgccagcttt 2633041 gacagaatta ttttatatga ctggcattat gagaaattgc cgatatatac ggaaacagga 2633101 caccactttt tccttggaga ttgtttgtat tttaagaatc ctgaatttga tccgcaaaag 2633161 gcgcaatgga gaggcgaaaa tgtgatacta ctgggggaag ataaatattt tgcccatggt 2633221 cttggaatct taaacggaaa gcaaattatt gataagctga attcttttag gaaaaaagga 2633281 gccttacagt cagcctacct tctgtctcag gcgaccagac tggatgttcc gtctcttttc 2633341 cgcatcgtcc gctaaaaagc cccatcgcct attttccgga cgatggggtt tcaaatgcct 2633401 ttcgttttcg atagaagggg gctgtgccaa aatattggtt cgcagcccac tccatttttt 2633461 caaggtcatt tcttgtcacg attggatcct ggctgctcca tttgataaag cggacaaaat 2633521 agtagccttt gataggaacc attgtaactt ttgagtgagg ccagccttca aatacaaact 2633581 caattttccc tcttttttta taagaatatt gaagaatgtt catatctgtc acctcagttt 2633641 atcaagttac gttcggcaaa gctcggtacg tttacatcca ttgattaact atccctcatg 2633701 caggctttcc ggaaaacaaa gggtgaggcg cgtgtctctt tccctcgctt tttatttcgc 2633761 atatggacga atgccaagca cgccttcatt cgataaagcc gcagcgtggg cgggtgtgac 2633821 aagccctccg gctatcggcg cttgttcagc gatcatgctt ttgtcataaa aaacagccta 2633881 ttatcccatc attttgatat agcatgtccg ggtgcgaggc ccgtcaaatt cgcagaaata 2633941 aatgccctgc cacgttccaa gaataagccg gccgttttcc acaatgacat gctgtgaagc 2634001 tccgaccgta ctcgacttca tgtgtgcagc tgtattgccc tccatatggc ggtccagctc 2634061 atgttcccac ggatatacct catcaaacct tctgagcata tcttttttga cgtccggatc 2634121 ggcattttca ttaattgtaa tgcccgcagt cgtatgcgga cagtaaatca gcgctgcgcc 2634181 gctcgttata cctgtttctt gaagaaacgc ttccacctcc cgggtgatat ctatcatttc 2634241 atctcgtttg gttgttttga tttgcagtgt tttcagcatt tgtttctcct ttcgtttgtc 2634301 cgctctcatc gcttaattcg ttctgtgttc ttttttttcc tgttaaaccg ctctcataaa 2634361 cccgataaaa caaaaaaact ccagtctaag gctggagttt agcaccatag atatattctt 2634421 gcttcatacg gctttaagag tactgatgtc atatgcttgt gcggctctgt ttcaatattt 2634481 gacaagacga gtgcatctga tgacaatggc aatccagagt gcctgaacaa cgccggtgtt 2634541 cctgtcagat tggccgcaat cagtgcagta tggctctcgt ttttccgaag atatgcaaag 2634601 atttgctgat cttccggtaa aatgagctcg tatgtcccgt taataaaaac atcatatgtt 2634661 tggcgcagct tgatcaagct tttgtaaaaa tggtaaacgg atgttttatc gtttttttgc 2634721 gcctcggcat tcagccattt gtaattctca ttgattccga tccacggttt ggcctcagaa 2634781 aatccggcgt atggaccagc attccattgc atcggcgttc gcgaattgtc tcttcccttt 2634841 ttccagacaa tcttcatcac atcctcgtgt gatgtgcctt tcgctgtttt tgtttcatac 2634901 aggcgtttca atgcgacatc atcatagtcc tcaatagatg gaaaagccac gttcgtcatc 2634961 ccgagttcct gtccctgata aataaacggt gtgcctttca tgagaaaata aacagcggaa 2635021 agcgcttttg cactttcttt caggtacact ccgtcgtctc cccacacaga aactgaacgg 2635081 ggctggtcgt gattctccat aaacaaagca ttccagccga tcccttccag actgtcctgc 2635141 cagtcagtta aaattcgttt aaatgcaacg atatcaatac tttcattgat ctctacatcc 2635201 cacaggccga gatgctcaaa ttgaaaaatc atgctgaata tgccgttttt ttctccagcc 2635261 caatcagctg cttcttttgc agcgacgccg tttgcttcac caactgtcat aatcggatag 2635321 cgggaaaatg tgttttcctt cagctctgtt aacaaatcca taatgccgtc agcattcata 2635381 tgataaggaa aggaagggac atagtccagt ccctttggat tcggcatgtc aggaaaccct 2635441 tcttttttct taatatgcgt aatggcatcc acccgaaatc cgtcaattcc tttatcaagc 2635501 caccaattga tcatgtcata aacggcattc ctcacctttt cattttccca attcaaatca 2635561 ggctgttttt tatcaaaaag gtgcagataa tactggcttg tcttttgatc atactcccaa 2635621 gccggcccgc cgaaaatgct ttcccaattg ttgggcgttt ttccgttttt gccgtctttc 2635681 caaatatacc agtcgcgctt ttccgagtgt atggatgaac gggattctat gaaccatgga 2635741 tgttcgtcgc ttgtgtggtt cacaacgaga tccataatca gcttcatatc cagatcatga 2635801 atgtcaccaa gcagctcatc aaaatcttcc atcgtgccaa actcgcttaa tatgttttga 2635861 taatccctga tatcatagcc attatcggca ttcggtgaat catacagcgg gcaaatccat 2635921 atgacgtcag cgcccagctc ttttatgtaa gaaagcttgg ttctgattcc ttgaatatcc 2635981 ccgattccgt cgccatttga atctttaaaa ctgcgggggt aaatttggta aactacggct 2636041 tccttccacc aagccttttt catacagcca ctccttccca gtgtaccgtt cttatatatc 2636101 ctatgtagaa aaaggtcttt acagcattgc tttttaagaa atgacttgat gacacaaaaa 2636161 acagccgttt gttccccggc tgttttttat caaaaatcag ttttttttat ttctacaaaa 2636221 cggatgtggt gatcttcggc gtcgaggatt ttaaattcac agccctccgc gtgtatcaca 2636281 tcccctgctt tcagctccat tttttgcgtt agaagccagc ctgcaatcgt atcaatttct 2636341 tcattttcaa tcgcaatgtc gagaaggtca ttcacttcgt ctattagcgc ttttccatcc 2636401 atcacataat ggtgctcgcc ctttttcagg atgtgcggtg tttcatcctg atcatactca 2636461 tcgcggattt ccccgacgat ttcctcgata atatcctcta cagtgacaag ccccgccgtt 2636521 cccccgtatt catcgacaag aatcgccatg tgaatccgct ccttctgcat gcggattaaa 2636581 agctgctgaa caggaatgct ttcaatgact ctgataacgg gcctcatgat ttgattcagc 2636641 tttatcggct ggccgagaaa ataagcttta aacatatctt tgctgttgat gatccctaaa 2636701 atatgatcct tgtcatcttt gatgacaggg tagcgtgtat accgttcatt aatgatgtga 2636761 tgaattgcct cttcaagcga ctgctccaga gagataaccg caatttctgt ccgcggaatc 2636821 ataatctctc tcgctacccg gttgtcaaat tcaaaaatct tatttacata gcggaattca 2636881 gactgattga tttctccctt ttcatagctt tcagaaagga tcagccttag ttcctcttcg 2636941 ctgatgacaa cctgatgctc ctttaccgaa tgaaagccaa acaatttcac aagaaaactt 2637001 gcagagccgt ttaatgcttt aataaacggg tacgtgattt tataaaacca gatcagcggc 2637061 tttgcaatcc ataagcttac agcttcagct ttttgaatag aaaccgtttt cggggcaagc 2637121 tcccccatca ccacatgcaa aaaagtgacg atgataaatg caactacaaa tgtgacaatg 2637181 tggttaaacg gttccggtat gcctgtcatt gtaaataagg gatgaagaaa acgttcaaat 2637241 gtaggttcac caagccaccc aaggccgagg gctgtaatcg taatcccgag ctggcaggct 2637301 gataaatact cgtcaagatt ggagatgatt ttatgtgcgg ctagtgctcg gctgtcaccg 2637361 ctttcgatga gctgattgat ttttgaacct ctgattttga cgatcgcaaa ttccgctgca 2637421 acgaaaacag ccgtaatgcc aatcaaaaca aaaatggcga tcaattgtaa aataagcaaa 2637481 aaaagccctt accataaatg gtaaggggcc acctccttaa cgttaattct catcacgacc 2637541 gtttaagaaa atcatcacaa aacgaagtag ttcaaacagg gaaaccaggg cggcggccac 2637601 atacgttaag gcagcagcac tcagcacttt atttacccca ttttcttcat tgtttcggat 2637661 gaatccttct gacacaataa tctgcttcgc acgtgaactt gcattgaatt cgacaggcaa 2637721 tgtaatcagc tggaaaaaga cagccgctga aaacagtatg atgccaagcc cgatcaaatt 2637781 caggctgccg agaagcatgc ctcctaagaa aagcaaagga gctacaccgg atgcaaaatt 2637841 cacgactggg aagattttat gtctcagcac aagcgcacca tatgactcct gatgctgcaa 2637901 ggcatgtccg acttcatggg aagctacgga tatggcggaa attgagcggc cgtaatagac 2637961 cggctcagat aaacgcacca cccgtcttgt cgggtcgtaa tggtctgtta aagtgcctct 2638021 taccggttcg accggcacgt cgtaaagacc gtttatatct aaaatccgtc ttgccgtttc 2638081 tgcccctgta cgtccgcttg aggcttccac ttttgaatat ttttcaaagt tgctctttac 2638141 tttaaattgt gcccaaaacg acaatcccaa tgcggctatt gttaaaaata taaacagcat 2638201 tttttcatca tcctttgttc atgatcattt ctctattacg attattttaa tgagttttct 2638261 ttctcgtgta cagaaatgcg ctttttcttc cggcttggag cacacaatcc aatcagcaaa 2638321 aagaacaggc ctgctgaaaa caaataaaag gcgaaactgc cggccagttc tttcagaaaa 2638381 tgaagccagg agaagcttcc ggaaaagtga ttatatgaat tcaaatcgaa aataaacaaa 2638441 atcaccgcgg atgccgccag ctgcgtaccg attaaaacca cgatcgttct ttgaaagatc 2638501 gtcatctttt tcatcctttt tgttttagtt tatggagaaa tccggtttta tatgttttgt 2638561 acattttttg aaaaacatca ccggaagtgg gacatactgt tagaaaaaag cacgggtgtg 2638621 atggaagcta tgaaagtgac gagtgaggaa aaggaacagc tgagcacagc aatcgaccga 2638681 atgaatgaag gactggacgc gtttatccag ctgtataatg aatcggaaat tgatgaaccg 2638741 cttattcagc ttgatgatga tacagccgag ttaatgaagc aggcccgaga tatgtacggc 2638801 caggaaaagc taaatgagaa attaaataca attattaaac agattttatc catctcagta 2638861 tctgaagaag gagaaaaaga atgaaatcaa atcggatatt tatttcatgg ctcaggtggc 2638921 cgttatttat ccgaatcggg gttattattt tatgtctgat tcttttgttc ggccaaatca 2638981 tttatatact tgagcctaag cagttcactt cggtattcga aggtatttgg tgggctgtcg 2639041 ttacggtttc tacagtcggt tatggagact atgtgccgca cactccgctg ggacaggcag 2639101 ccggaatact gctgattttg agcggagcaa gctttgtcac agcgtatttc gctacgttat 2639161 cagcggccgc attcagcaga cagcatcgct acattgaagg aaaagttgct tacaaaggcc 2639221 gggaccacat cattctgatc gggtggaatg aaaaaacaaa ccggcttttg aaggaccttc 2639281 agcttgccgc cccttccaaa acagtcgtac taatcgatga atccttaaca gaaggcccgc 2639341 ttattgaaaa cgttcatttc atacgcgggc acgctgccga tgatgggaca ctgaaacggg 2639401 ccaatattac tgaagcggaa tcagtgatga ttactgccga tcagtataaa agtgaaactg 2639461 atgctgatat gctgtcagtg ctgactcttt tatctgttaa aggtcttaat ccccttgctt 2639521 actgcatcgt cgagatttta actgaccgtt ttgtcaccaa tgcggaacgg gcaggcgcaa 2639581 accaaatcat cggaacttca gaatttatca gccgggcgat gctgcagcat taccaagtca 2639641 agttacggcc gtctaaacag cagaacggaa tcaagctgac acttgatcag catgtggagc 2639701 ttcttgctgt tcctgacgaa ctaaagggag cggcttacaa aacctgtgtt ctctatttcc 2639761 ttgatcacaa cacaacaatt ataggcatac aaaaaaagga ggggccgatg ctttcccctc 2639821 ctcttacata caaggtgctc gaaacagatc aattccttgc catctagtgt aacagaacat 2639881 cctccaattc tttcacgaga gaggcgccga tatccaaaaa tgccggatca atttccgcgt 2639941 cccgcctttc cggttcggaa aattgattaa acagtgattg gaaaggccct ccctcggcgt 2640001 gatcgtcaac atccgcctga aacacctgtc tcagcataaa tggcgttccg atccggacgg 2640061 ccgcccctcg ttcatcgaga ctgccctgta ccgcattgac gggaattctt aaaaataaat 2640121 agccgtctct atcatcaatt ttataatcaa agtagccatg atcgtattcc cagccgccgt 2640181 ttatcacata accgagcggc ttcatcactt gttccagttc ttgaagcaga aaagactgcc 2640241 catctatcgc ggaaggtatt ggtatcatca gaatgcccct tttttcactt atcctgtccc 2640301 gccgaacaag acttcattca gaggcgccta catggaaatc gttgtttctt tcgcgcggcc 2640361 aacaggaaag aaagcgcatt caattaagaa gtaaacagcc attgccgctg caagccatac 2640421 agctgaatcc caagacacat aaacaaccgt tgcatagagt cctaatttag tgaaaagagt 2640481 atgggttcgt tttaaatgca aaatccgatg taccgcatcg gtaaaaaggg caagcggcaa 2640541 accaatgaga agaaaggagt ggatgaaaaa atgtgacagc gtgccgccaa agcttgaaga 2640601 aaaccctgta tacacggcat caaaggagat aaggaaactt aaaatagctg cagaaaaacc 2640661 ggcaatgatg agatgtttaa ccaattgttt catgaacatc agcacctttc tgattttata 2640721 aaaagccgac cggcaaatgc cagtcagctt tctcacatta atcttccaga cgtttttcaa 2640781 gctctgcttt tttctcttca aagccaggtt tgccgagtaa cgcaaacata ttgactttat 2640841 acgcttctac accaggctgg tcaaacggat tgacgccaag gaggtaaccg ctcatcgcgc 2640901 aggctttttc gaagaaatat acaaggtatc caaaagtata tgcattcagc tcaggaatgt 2640961 taacgattaa gttcggaaca tttccgtctg tatgggcaag cattgtacct tggaatgctt 2641021 ttttgttaac gaaatcaaca gttttaccgg ctaaatagtt caagccgtca agatcgttat 2641081 ccgcttcctc aattgtcagt tcatgtttag gcttctctac gttcaggacc gtttcgaata 2641141 aatctctgcg gccttcttgt acatactggc ctaaagaatg aaggtctgtt gaatagttcg 2641201 ctgaagaagg ataaatgccc ttctcatctt tcccttcgct ttctccgaac agctgcttcc 2641261 accattccgc aaagtattga agcgccggtt cgtagttgat gagcatttca attgttttgc 2641321 ccttattata aaggacattg cgaacaaccg catattggta tgctgggtta tcttccagtt 2641381 cagatgttgc aaaatctttg ctcgcatcca gggcgccttt catcatgtcg tcaatgttga 2641441 cgccgctgac agcaatcggc aagagaccta cagctgttaa aactgaataa cggccgccga 2641501 catcgtcagg aattacgaat gattcaaagc cttcttcgtt agaaagcgtt tttaatgcgc 2641561 cgcgctcttt atcagttgtt gcataaatcc gcgctttcgc ttcttcttta ccgtatttct 2641621 cttcaagaag cttgcggaaa atacggaaag cgattgcagg ttcagttgtc gtacctgatt 2641681 tagaaatcac attaatagag aagtcaacat cttcaagaag atccatgacg tctctcatat 2641741 aagatgaact gatgttgttc ccgataaaaa tgacttgcgg attgccgcgt tttgcttttg 2641801 gcaaagtgtt ataaaacgcg tgattcagcg cttcaatcgc tgcccgcgct ccaagataag 2641861 aaccgccgat gccgacaaca agcaagacat cagagtcaga tttgattttt tccgcgcttt 2641921 ttttgatgcg cgcgaattct tctttatcat aatgttcagg gaggtccacc cagcctagaa 2641981 aatcgctgcc cgcgcctgtt ttctcatgga tattatggtg tgctgttttt acaaagtccc 2642041 gcaggtatgt aagttcatgt tcgttgaaga aagtcaacgc ttttgagtag tcaaagcgta 2642101 catgcgtcat tgcttgtccc tccataacgg tataatgttt tcatctttca ctttatatga 2642161 acttatctgt gaaatcaagt caagaagaaa gggcggaatg actggattcc gccctttggg 2642221 tttatagaga cgcgcgaagg atggcaagca cgtcatcttt gttcagtttt tggaagttgc 2642281 cgaagccgcc gtgttccatt tccttggctg cgatatcagc aatcagctca agcttttctt 2642341 ctccaatatt gtaatcagca agacgagaag gtgcaccgag gcttgtccag aacgcagaca 2642401 gtttatcgat tccttcaagc gcaatttctt tatctgtttt gccttcagta tcaatgtcaa 2642461 acatgttgag cataaggttt ttaaaacggc ctacatttgt atcaagcgtg tatctcatcc 2642521 aatttgggaa cagtattgcc aaaccgcccg cgtgcggaat atcatataca gctgaaacag 2642581 cgtgttccat tgtatgagaa gcccagtcac cgaagtatcc catttggagc gtgccgttta 2642641 aagcaatagt accagcatac aaaatcgttt cacgaagttc gtagttttcc agatcttcaa 2642701 gaagcttagg agctgtttcg atgaccgtct gcaaaacagc aaagcacatt ctatcctgaa 2642761 gcggcgtgtt ttcaacatta tggaagtatt gttcgaatac gtggctcatc atgtcaacca 2642821 tgccgtatac tgtttgattt tctggaacgg tgaacgtatt ttcagggtct aaaatagaga 2642881 aacgcggatg agtgacattg ctgccccata caaatttctc gtttgtttcc cagtttgtaa 2642941 tcacggaatc agggttcatt tcagaccctg ttgcagcaag agttaaaaca gtgccaaacg 2643001 gcagcgcatc ctccgctgtt acttttttgc tgaaaatatc ccaagcgtca ccgtcatatt 2643061 tgacgccagc tgcgattgcc tttgtacagt caatcacact gcctccgccg acagcaagca 2643121 gaaaatcaat gtcatgctct ctgcaaagtc ctatgccttt ttccactgtc gcaagacgcg 2643181 ggtttggctc tacacctgac agctcatgaa caacagcgcc ctcttctttt aaaatgcctg 2643241 tgacttgatc ataaaggccg ttgcgtttaa tgctgccgcc cccgtaaaca agcagtacat 2643301 tcttgccgta tcgtttgaat tcttttctta attgttcaag ctgacctttt ccaaaaatca 2643361 gctttgtcgg attataataa gtgaaatttt ccatagtaaa acctccaaat gatgctggta 2643421 aaaaacagat tttccattgt aacataagtt gacaaaaaag aaaaagggaa gcagccaaac 2643481 ggctatttcc ccttttttta tagtgatgct ttcaaaattg acagcacatc ttctttgttg 2643541 agtgatttaa attggccgaa tgtaccgtta gccattgcct tgtcagcgat tgtgtcaagc 2643601 tgctcatcat taatatcata atcagcaaga cggttcggag cgccaagact tgtccagaat 2643661 gcggacagct tatcgatacc ttcaagggca atttcttcat ccgttttacc tgcttcttca 2643721 acatcaaaca cgcgaactgc aagctgtttc atgcgggcag ggttttcaga caatgtgtgt 2643781 ctcatccaat tcgggaacag aatcgccagt ccgccggcat gcggaatatc ataaacggct 2643841 gatactgcat gttcaatatt atgagtagcc caatcccctc ttgcccccat agaaagcatg 2643901 ccgtttaatg cgattgttcc tgtgtacagg atcgtctcac gcaattcgta attttcgaga 2643961 tcattgatca gcttaggcgc tgtttcaatg actgtacgca aaagtgattc acacatgcgg 2644021 tcctgatacg gcgtgtttga tacatgatgg aagtattgtt cgaatacgtg gctcatcatg 2644081 tcaaccatcc cgtagatcgt gtggttttta ggtacggtga atgtattcac cggatcaaga 2644141 atcgagaatt tagggaatac gagcgggctg ccccagccgt atttttcttt tgtttcccag 2644201 tttgtaataa cagatcctga gttcatttct gaaccagttg cagcgagagt caataccgtt 2644261 ccgaatggca aagcatcttt tggctgatgc tttttcgtaa cgatatccca cgcatcacca 2644321 tcatacttcg ctcctgcggc aatcgctttt gtacagtcga ttacgcttcc gcctccgaca 2644381 gccagcaaga aatcaatgtt ttgttcttta cagatggcaa cacctttatt aacagtcgac 2644441 acacgaggat tcggttccac acctgctaat tcatgcacgg tcgctccggc tttattcagc 2644501 tgttcaatca cttgatcata caggccgctg cgtttaatgc tgccgcctcc gtacacaagc 2644561 aatacgtttt ttccgtaagg tttgagttcc tccggaagtc tttccacttc gccgcgcccg 2644621 aaaattaatt tggtcggatt ccagtatgta aagttttgca tgacatctcc tccttagatt 2644681 ttttattatg cagaatgtcc tcaccacatg taaagcaatc agctctcacc gatcagcata 2644741 ccagatggtt ttattttgca aggtgctggg aaagaagctg atataagcga gggcaggcca 2644801 gcttccctca tatggagaat gcatgtatag attctccaat atgtcacaat ctataactgt 2644861 tttaataatt catggaggag gttgcaaaac atgagtacca ttcaaagaat ttgtcttgta 2644921 ttaaccatca ttggcgccat taactgggga ctgatcggat ttttccaatt tgacttagta 2644981 gcggctatct tcggcggcca agggtcagct ctttcccgaa tcatttacgg acttgtcgga 2645041 atcgccggct taatcaacct cggtctgcta tttaagccaa acgaggaaag atcacgtgaa 2645101 gaagcagcaa atcctgaaat gcgataggat atcaatcacg ctgaaatagg attttgcatg 2645161 aaatcaaaag caccgaacat tcctgtccgg tgcttttttc atgcttattt tttgataagg 2645221 tctttgcggt tggacatttc gatccactct tcaagcttat cttttaatgt gttgaaacct 2645281 tgtggtgtag aagcttcttc gcttacttga gcagctttag gttttcttgg tttgctttct 2645341 tttttctcag gcgcagcttg tgtcgcacga attgaaaggc tgattttgcc tttttcttca 2645401 tcaacagcaa gtacttttac ttgtacttcg tcgccaactg aaaggtgctc gttgatatct 2645461 tttacgaaac cgtgagtcac ttcagaaatg tgtactaaac cttgagtttc ttcatctaat 2645521 gcaacaaacg caccatacgc ttgtaatcct gtaactttac cagtgtaaac actgcccact 2645581 tcaaattttg ctgccattca taacaactcc taagttaaat taaatatctg tttatacgca 2645641 atttaaaatt atatcacaca tgtcttattt ccgcaaagaa aactttttta taaaaaatca 2645701 ggtttatgca cagcaaaaag ggggtaaact gaaaatacca aaggctttct agtattcccc 2645761 ccttttattg gatgcgaaca aaaggttcgt atcttttttt atgttgtttt gtgcaggaag 2645821 cgtttcattc tgactaacgc ttcttgaagc tgttcaatcg aggttgcgta tgaacaacgg 2645881 atatatccct caccgctcgg accaaacaca cttccaggaa caactgccac tttttcctgc 2645941 gtcagtagct cctcggcaaa ctgttctgaa ctcattccca tgcttttgat agatggaaaa 2646001 gcatagaaag cgccgcccgg atgatgacag ctgagaccga tttcattgag cgattctaca 2646061 aacagattcc gtcttcttcg atagcttttt ttcatttttt ctacgtcttc catgccgttc 2646121 ttcaggcctt caagggcggc aaactgcgcc attgcgggcg cgcacatcat cgcatactga 2646181 tgaattttaa gcatggcatc ccgaagcaag gatggtgccg cggcaaaacc gagcctccag 2646241 cccgtcattg caaatgcttt tgaaaagcct gagatgacta ccgtccgttc cttcattccc 2646301 ggtaatgccg ctatacttgt aaattcctca tcatatgtca gctccgcgta gatctcgtcg 2646361 gctaagacga tgacatcatg ttttttggca aactcagcaa tctcattcag ctcttccttc 2646421 gaataaaccg aacctgtcgg attcgatggt gagcagatga gaatggcctt tgttttttca 2646481 gtgactgccg cttcaaaatc agcagccgtt gctttaaatc ctttgtctgc cgttgtatga 2646541 acgtgaaccg ggataccgcc tgccaaagaa acaagcgcat cgtacgcaac aaaacacggc 2646601 tcaggaatga tgacttcctc acctggattc acaatggcgc ggatcgcaat atccaaagcc 2646661 tgacttgccc ccactgtcac aatcagctca ttatctggcg agtagctaag gtcaaacctg 2646721 ttgctcaaat aacggctgat ttcctcccgc aatgagtata aacccgcatt ggccgtgtat 2646781 gacgtatatc cttgttcaag agagagaatg cttgcttcgc ggacattcca tgcggtaaca 2646841 aaatcaggct cgccgacgcc taaagaaatg acgccttcca tcgttgccgc caaatcaaag 2646901 aatttgcgga tgccggatgg ttttatttgt tgtacatagt ctgataaata cgaagtcatt 2646961 tacggtgaca ccacgattct tttgtcgtcg tctcctgttt caaacacttt gccgtcatgc 2647021 ttgtattttt tcaggataaa atgggttgtc gtagatacaa ctgaatcaag cgttgagagt 2647081 ttatccgaaa caaaacgcgc tacgtcagac atcgaattgc cgcgaatcac gacagacaaa 2647141 tcgtatacgc ctgacatcag gtaaactgat tcaacctctt ggaatcggta aatccgttcc 2647201 gccacttcat caaaaccgac gccccgcttc ggcgttactt tgacgtcaat catggccgta 2647261 acgccctcat gtccgtcgac ttttcgccag tcaatcatag cggaataatc gataataacc 2647321 ttttctttct ccagtttgtc aataattgtt ttcacttcat ttacagggat gcccgccatc 2647381 tttgcgattg tttctaaatc ggcgcggctg ttttcgtcta aaatttctaa tatttctgtt 2647441 tctttttctg tcaatttcat ttgattcaca cctttgcaat gtcaagaaat ctcatgacat 2647501 tatatcacgt tttttgacga atgctaagaa aaaacgagga gaaacttccg ctagaattga 2647561 caatttcagg gcataataca accatcaaaa aaagggagtg acacagaatg gaggcggttt 2647621 caccaataag gcggtttacg gtcgatggag tcaatgtata ctacgaacat tatcaaaatc 2647681 ccggcaggca aacgctggtc tgcgtacacg gttttttatc atctgcattc agcttcagaa 2647741 aagtaattcc tctccttcgg gacaagtacg acatcatcgc gcttgatttg cctcctttcg 2647801 gccaatctga aaaatcaaga acgtttatct atacctatca aaaccttgct aagcttgtca 2647861 ttgggatttt ggagcacttg caagtgaaac aggctgtgct tgtcgggcat tctatgggcg 2647921 ggcagatatc gctgtctgct gctctccaaa aacctgagct tttttcaaag gttgtgctgc 2647981 tttgcagttc agggtattta aaacgttcac acccgacgat tattttcggg acccatatcc 2648041 cgtattttca tctttacatc aaacgctggc tctcgaaaga aggcgtgatg aaaaatttat 2648101 taaatgtggt gcatgacaaa tcgctgattg atgaggagat gattgacggc tatggcagac 2648161 cgtttcagga cgagcagatt ttcaaagcca tgacaaggtt tatccgccac agagaaggag 2648221 atttagaacc cgagcaattg aagaaaatga acaagcctgc tctattgatt tggggcgagg 2648281 aggatcgaat tgtcccaatg gagatcggta aacggctgca cgcagatttg cctaattccg 2648341 tgctgtactc acttggccag accggacatc tggtgcctga agaacggcct gaacttattt 2648401 ctgaacacat tgctgatttt atcaaataac aaaaaaaccg gtgctgaacc ggttttttta 2648461 aggcgtgcag gagctgctgt ttttaatgaa taaaagctgg ccagccactt cccggcagct 2648521 ggcgatcggc agcgtttgtt caaaagaagt ttcaaatatt tgctgaatgc ttttcgccag 2648581 caagtcggga tcgttttcat catagactgc ctgcacgaca tcaacagcct ccgtttcgta 2648641 aaactcttct ccatatttaa acgggtccca tttggcaatg atcttaatca tttccctgac 2648701 cgcatgactt tcttccatat tcatcaccgc ttataataaa atttgcagtt ctatcttatc 2648761 atagtgaagc ttagaagaat aaacatacat gagggggtaa cagaatgaac tttgataaac 2648821 gagaagaacg ccttggcacc caatcggtca aatgggataa aacaggcgaa ttatttggcg 2648881 tgacagacgc cctcccgatg tgggtggcag atatggattt tcgcgccccg gaagcgataa 2648941 ctgaagcgtt aaaagagcgt cttgaccacg gtatttttgg ttatacaact ccagatcaaa 2649001 aaacgaagga tgctgtgtgc ggatggatgc aaaacaggca cggctggaag gtaaatccgg 2649061 aaagcatcac attcagcccc ggcgttgtaa cagctttgag catggcggta caagctttta 2649121 cggagccggg cgatcaagta gttgttcagc ctccagttta tacgcctttt taccatatgg 2649181 tggagaaaaa cggccggcac attttacata atccgctgct agaaaaagac ggcgcatatg 2649241 caatcgattt tgaagatttg gagacaaagc ttagtgaccc aagcgttaca ttgtttattt 2649301 tatgcaatcc tcataaccct tctgggcgtt catggagccg ggaagattta ctgaagctag 2649361 gcgaattgtg ccttgagcat ggcgtcacag ttgtatcgga tgaaatccat tccgatttaa 2649421 tgctgtacgg acataaacac acgccgttcg cttcgctctc tgacgatttc gctgatattt 2649481 ccgtgacatg tgctgctcca agcaaaacat ttaatatcgc cggattgcag gcttcagcga 2649541 tcattattcc ggatcgcctg aagcgcgcca agttttccgc aagccttcag cgaaatggtt 2649601 taggcggact gaacgcgttt gccgtcactg caatcgaagc cgcgtattca aaaggcggac 2649661 cgtggcttga tgaattgatc acttacattg agaaaaacat gaacgaagcg gaagcctttt 2649721 tgagcaccga gctgccaaag gtcaaaatga tgaagccgga tgcatcatac ttgatttggc 2649781 tcgacttcag cgcttacggc ttgtccgatg cagagcttca gcaaagaatg ctaaaaaaag 2649841 gaaaagttat tttagagccc gggacgaaat acgggcctgg cggagaagga tttatgcgcc 2649901 tgaacgccgg atgctctctt gcaaccctgc aggacggcct gcgccgcatc aaagccgcat 2649961 tatcgtaaat atagctgtaa acgcctttac gtcttcattt gtaaaggcgt tcttaataaa 2650021 ggaattttat attttacttc taatatttag tgttataata gattcatatt ttatacgaaa 2650081 ggatttcaca cgaatggaaa ttctaaaaga ctatcttctg cacatctgct ttattttgtt 2650141 tcctattctt ctttaccaag tgttttggct tggaaaacct gcgattcttg tgccaaaaat 2650201 aaacagcggt ttggtcacgc tcttcgcctg cggcgcctcc gttttatgca ttattttccc 2650261 gattcatgaa atggactaca tacaatacgg ccttcagatg attcccgtta tcatttgttt 2650321 attttacatt agtaccgctt ccggacttac agtcgccgca tctgtcctat gttttgaact 2650381 gcttttttac gaaccttccg caatgtttgt tttcactttg ctgccttttc ttatcattat 2650441 cccaatctta tttcagaaaa aatggccatt catgtccaaa gcgaaaaaac tgctgctgtc 2650501 tttattgatc agctgcgtgg agattttcct atttttcgcc tcaagctgga ttctttccgc 2650561 cttgaatatt ttaaattttc aaaaatcagg aattttcgtt tacgaggcgg cagtctcagg 2650621 gcttttccgc tccagtgttc ttctattaag catctatatt atcgaaagca tcgccgaaaa 2650681 tatcgccctg cgttcacagc ttatccattc tgaaaaaatg acgattgtga gtgaactggc 2650741 agcgagcgtc gcccatgagg tcaggaatcc gctgacagtt gtccgcgggt ttgtccagct 2650801 gctttttaat gacgaaaccc tacaaaacaa gtcgagtgcg gattacaaaa agcttgtact 2650861 gtcagagctt gaccgggcgc aaggcattat cacaaactat ctcgatatgg ccaaacagca 2650921 attatacgaa aaagaggttt ttgacctatc tgcccttatc aaagagacaa gctcccttat 2650981 ggtgtcgtac gccaattaca agtcagtaac cgtcgaggct gaaacagaac cggacctttt 2651041 gatatacgga gacgcaacaa agctgaagca ggctgtcatc aacctgatga aaaacagtat 2651101 tgaagcggtt cctcacggga aggggatgat ccacatatca gccaaaagaa acggccatac 2651161 gatcatgatt aacatcacag acaatggggt cgggatgaca gaccatcaaa tgcaaaaact 2651221 cggcgaacct tattattcct taaaaacgaa cggaacggga ctcggcctca ccgtaacctt 2651281 ttccattatt gaacatcatc acgggaccat ttcatttaac agcagcttcc aaaaaggcac 2651341 tacggtgacc attaagcttc ccgctgatct tcctcactag caaatcgatt ggaactttaa 2651401 tagaataaat gcgaggtgat gacagatgag cacgtttgag acaggctcta tcgttaaagg 2651461 attttacaaa acaggtgtat acataggaga aatcacggct tgcaggccgc agcattattt 2651521 agtgaaagtg aaagcggttc ttacccatcc cgctcaggga gaccttcatc atccaaaaca 2651581 ggcggatgtg ccattttttc atgagagaaa agcgctcgca tatggtgaac agaccaatat 2651641 cccccaccat atggtgaagc cttatgacgg tgaagtgccg gattataccg aatctctgcg 2651701 ggaggcgaca gcacagatga gagccaaatt gaatgaggat ggttcggagt gggcaaagcg 2651761 ctcccttcat aatctggaca ttttagaaaa agaatatttt aaccggccat aacccagtct 2651821 gacaaaagat tgggtttttt acgtcgcgcg cttcaacagt tcggttaaat cgattctctc 2651881 gccgattgtg ggcggttttg gcttttcgag atactgctta tcctgctcaa caagcttaaa 2651941 aagtttatat gctgtgagag catcatcaag cgctttatga tgggtgccgg ttccggaatc 2652001 tccatactct tcggcagctt tccataaacc cgtcaatgtc cggtctccaa aaaagttttt 2652061 gtattcaagc gataaatctc tcatttctcc cttaaacggg aaagggatat ggttaaacat 2652121 acagttttgc ttcagcactt tcatatccat gtttccccac gtaataattg tgctgttttt 2652181 ctcaggatcc agctcgttta gtttacggat gaaatcctcg aatctcattc cttcgtctac 2652241 ctgtttttgg gttattttta aaaatgattt gcagcgtttc gtaagcttcg ggaacttttt 2652301 cggtctaaca tagctagaaa acgtctcaac cacttcatca tcaatcgact ttacaattcc 2652361 ggcttcaatg atttccggga agaagttttg aggactgtac tttccatcag gcattgtaaa 2652421 ttcgaaatca ataatgagta agctgtttgt cgtcaccttt tacacctgcc tttcctccga 2652481 tcagaaaatg ctatctttat agtatatcaa ttccccttct cgacatttct tcattttcta 2652541 aaaataatga attttcccag ccgcttcgtt tcttttaaat tgtgaatcgt ttctttataa 2652601 ttagtaagga acccgaaata ataagaaggt gatgttattt ctatccgtaa gaaaaacttt 2652661 gtcattgtgt ggctggcgaa cttttttgtc tccgctagca caacgatgat cgttcctttt 2652721 ctctccttat acattgagac gctcagctct ttttcaaacg gctttgtgca aaggtggagc 2652781 ggctatgtgt tcggcattac atttctcatg gcgtttttgg tatccccgtt ttggggacgg 2652841 ttcggagaca aacgcggata caagaaaatc cttatggcaa ccggaacagg cattgccctc 2652901 agcattttct tcatgggctt tgttacatcg gtgtaccaat tgttttttct gcgtatggca 2652961 atgggtcttg taaccggatt catcccgaca tctcttgcga tgatttcggc acagactccg 2653021 aagagctcag ctggcaaaac actcggcacg ctgcaaatgg ggcaagtgtc cggaagcttg 2653081 ttcggcccgc ttttgggagg catgcttgct gatcgtttcg gctttacgta tacctttttt 2653141 atcacatcct ttgtgatttt ctcgtctgtt cttctcgtgt tatttggtgt caaagaaaag 2653201 catcttgcag agaaaacagc caaacgtacg tcttactcga gaaaagaagt gctctcctat 2653261 atttttcacc atccggcgct gtgggtcatg atgctgttaa ccatgctgat tcaaacaggc 2653321 aatttcagta tccagcccct gctcgcttta tatgtaaatg agctgcacgg acctgtcaat 2653381 cttgcctttt tctccggcat ggcattttca gcaacggggc tcggaagttt gctgctggct 2653441 agaaaatggg gtgatctggg cgaccgctac ggccaccgcc gcattttaat cggacttttg 2653501 ctcgccgcct ctttcttttt tattccgcag gcgctcgcgt cctcactcag cgtgctcctt 2653561 gttttcagat ttttattcgg aatggcgatg ggcggtttgc tgccatgcat tacggcagcg 2653621 atccgcgttc aggctcccgg cagcattcaa ggtgaagttc tcggctacaa tgtcagcttt 2653681 cgctttttag gaaacgtgct cgggcctctg ctcggcggaa tcatatcgag ccattttacc 2653741 atttcggcca ccttttacgt cacggcgttt ctctttttcg ccggcgcctg catgctttgg 2653801 atcatgcaga aacttcggaa agattcttat gccaaagcaa gctgattccg agaaaaaact 2653861 aaggaatctt ctaaatttaa ccttctcgta atctcaaaag aatggtacga tatggctaga 2653921 atttaggaga aaagagagtg accatgttac gaaaaataat cggatggatt ttgctccttt 2653981 gcataatccc attgtttgca tttacagtta tcgcttccgg aaaagaagta aaacaaatga 2654041 agtccctgga tcaggtgctt gataaaaata ttgatctgaa agatatcagc cttgttcaga 2654101 acagctacat gtatgacagg gacggctccc ttgtctcgga aatcgtcagc gaccacgaaa 2654161 accgtgtgct cgttccattt aacaagattc ccgaggaagt caaacagatt ttcttaacat 2654221 ctgaggaccg ccatttttac gagcataaag gctttgactt tatgggaatg gtgcgggcta 2654281 ctgcttctaa cgtaaaagac aagaaaattg accagggtgc cagcaccatc acacagcagc 2654341 tttcaagaaa cttgtatttg agccacgaac gctccttcag ccgcaagctg acagagctcg 2654401 cgtattccta tcagctggag aaaaaatata cgaaaaatga aattcttgaa gcttacttaa 2654461 ataccattta tttcaacaac ggtgtttacg gcgtcggttc agcagctcaa ttctatttca 2654521 gcaaaccgct gaaatctctc acagtgggag aaatggcttt tatctgtgct atacctaata 2654581 accctacatt atatgatcct ctcaagcatt ttgactacac gaaaagccgt caagaacgtt 2654641 tacttaaagg gctaaaagat gccggggtca ttacggacaa agagctgaaa aaagccgtaa 2654701 aacaaaaaat caaactggat gttgaaaaaa gagaagacaa atatcctgac tacgtttcct 2654761 acgtcaatga tgaattcact cagctggtgt ctgaatcaga aggctttgat aaacgccttc 2654821 aaaaagcatc aggaaaacaa aaagaaaaga tcgagaacga gctgtccgca agagtcagca 2654881 cgctgatgaa agacggagtg aaaatttata ctgcacttga tccgtacatg caaaatcaag 2654941 ttgtggcaca aatgaattcc aagctcccgt atgcggacgt acagggcgga gcggctgtga 2655001 ttaatcacca gacgcatcaa atcattgctc tatccggcgg gaaaaactat caaaaatatg 2655061 actttaaccg cgcctaccag gcgtacaggc agccgggttc atccattaag ccgcttcttg 2655121 attacggccc ttatattgaa cagaccggcg cgacaacaag cagcaccatt gatgccagca 2655181 agttttgcag caaagactac tgtccgcaaa actacaataa ccgcacttac ggcacagtga 2655241 cgcttgatac ggcgtttaaa aattcatata ataccccggc tattagaatg ctcgaccgcg 2655301 tcggcatcca aaaggcattc agttatattg agccgtatca ttttgccaaa cttgtcgaca 2655361 gtgactatct tcttccggcg gcgcttggcg gatttacaaa cggcatgacg cctcttgaga 2655421 tgacaaaggc ttatacgaca ttcggaaaca gcggaagcta tacgccgagc catgcgatta 2655481 caaaggtgac agaccttaaa ggaaaaacac tttataaatg gaatgataaa gcgactcaaa 2655541 tattcagcgt ccgcacgaac atgcagctga aaaaactgat gtcttccgtt gtgaaaagcg 2655601 gaacagggaa aaaagcatat ttcaatgcgc cttacatcgg cggtaaaacc ggaacatcaa 2655661 atgattatca cgatatgtgg tttgtcggcc tgactgatac gtatacaatg ggtgtctggg 2655721 tcggaaagga tacaccgacc agcgttgaat atcttcacag catcagccct cagctttcca 2655781 tctggaaagg aacgctgcaa gcggcttatt aaaggatcgg aggggatatg gagtgacttc 2655841 agaacaaatt ccaaatcgcg ttttgctgtt tgacggtgtc tgcaatttat gcaatggcgc 2655901 cgtgcagttt atcattaaac gtgatccgga cggattgatt tctttcacat cgctgcagtc 2655961 ggaaacagga cagagcctgc tgaaaaaaag cgggcttccg actgatcggt ttgacagctt 2656021 tgtctttatt gaagacggcc aagtgtacac aaagtcaact gcagccatta aggttttcag 2656081 gcatctgcga ggcccatggc ggctcttcgt cctttttttc gcagtgccga agcctgtcag 2656141 agatatggtc tattctttca ttgccaaaaa ccgctataag tggtttggca aaaaaaatga 2656201 atgtatgctc ccctcccctt ccattaaaaa aagattttta ccgtaaataa aaaatggcta 2656261 ggaagctagc catcacagat tgttgacaaa atcctaaaac ggcttcgttt taggattttg 2656321 tcatctattc agcgtgattg aaaacttttg aagttgtgaa acggcggaaa cctgagaatc 2656381 tagccgccgt ttcattgcgt acagagcacg aagcgcaaat ctgaccacca aacgctgaaa 2656441 tggctagctt acacaggtaa gctagccatt atgctattat aaagcttgat aaatatgaac 2656501 agaataccga taacaaaggt aaaccaaaac agcagttcca atagaatgaa tccaactaat 2656561 gacatgagag aaagcgtcga ataaatccgg tatacggtaa acacaaagta agcgagcgtg 2656621 acgaccgcaa accagatcac aatccaaatg acattttgca agagcacaaa ggataaaatc 2656681 ccgccgccca aataaatcat ggaacccatt ctgagttttt tcaggttgtt cccttccgga 2656741 tcattagcaa aaaacagcaa tgacagctcg gtcacggtat ttgcaattaa tttcagagcg 2656801 gacagaacca taaaatataa aagtgcaaag gcagcaaata acgcaagcct gattcctttc 2656861 tctgaaaaat aatcgagcat tccatcatac attccaaatg aagacagcat cttcaacgca 2656921 taaagtgaag ttgagatgga taaggacgaa ctaaaaagca ggatcgcaat cagcggaaaa 2656981 tatcctgtca aataagtatt tttcatataa aaaagtccct ttctataatc tacctcattt 2657041 attatggagg acttaaaaca cattgacaag ataaattatt ccattttttc tcctttttac 2657101 gaattacggg cccaaatctt cacaaagcag cattttgaga gtaaagtagt acgcaggaat 2657161 cataaaacgt aaggaagttt tatatgaaaa aaacattaaa actgcaaacc agactcacca 2657221 tatttgtttg tatcgttgta ttaatcgcat tgctcattac gttttttaca gtcggtgccc 2657281 aaaccaccaa acgaattaga gatcaggaaa aggccactgc gctgcagact gctgaaatgg 2657341 tagctgaagc gccgatgaca gccgctgctt tagaaagcgg aaaaaaacaa aaggaactgc 2657401 agagctacac aaagcgggtt cagaaaatta ccggcacgga atttgttgtc gtcatggata 2657461 tgaacggtat ccgcaaaact catcctgacc cgagcaaaat cggaaaaaaa ttcagaggcg 2657521 gtgatgagtc cgaggtatta aaagggcatg tccatatcag cacagcctct ggcacgctcg 2657581 ggaaatcgca gagagcgttc gtccctgtct acgcggagaa tggaaaacag gtcggtgcag 2657641 tcgcggtcgg catcaccgta aatgaaattg atgaagtgat cagccatagc ttacggccgc 2657701 tttactttat tatttgcgtc agcatcttcg tcggtgtgat cggagccgtt atcgtcgccc 2657761 gtacagtgaa aaatatcatg tacggacttg aaccttatga aattgcgact ctgcttgaag 2657821 aacggagcgc gatgctggaa tcgacgaagg aaggaatact cgctgtcgat gaacatggca 2657881 aaattaaact tgccaacgcg gaagcaaaac gcctattcgt caaaatgggc atcaacacaa 2657941 atcccattga tcaggatgta gatgacatct tgccgaaaag ccgcttgaaa aaggtcattg 2658001 agacaaaaaa acctcttcaa gacagagacg tccgcattaa cgggctggag cttgtgttta 2658061 atgaagttcc tatccagctg aaaggacaaa ctgtcggagc gattgcaaca ttccgcgaca 2658121 agaccgaggt aaaacattta gctgaacagc tttccggtgt taaaatgtat gcaaacgcac 2658181 tgagagcgca gtctcatgaa tttatgaaca aactgcatgt gatattaggt ctcgtccagc 2658241 tgaaagagta tgatgatctt ggagattata ttaaagatat agccatacag caaaaatcag 2658301 aaacaagtga aattataaat gatgtcaaaa gctccgtact ggccggtttt ctgcttggaa 2658361 agcaaagctt tatacgtgag cagggcgcaa atcttgatat tgaatgcaac ggtgtcatcc 2658421 cgaacgcggc agacccttct gtcatccatg aacttattac aatcatcgga aatctcatca 2658481 acaatggctt agatgccgtt gccgatatgc cgaaaaaaca aatcaccatg tccatgcgct 2658541 tccataacag catacttgat attgaaatta ccgatactgg agcaggcatg tctgaagaag 2658601 accaagccaa agtatttgaa caaggctatt caacaaaggg caaaaaccgg ggattcggcc 2658661 tttatttcac acagcaaagc atcgaaaatt taaaaggcca aatgatcctc acaagcgaaa 2658721 agaatgaagg aacgacattc agtattcgca tcccgtacga accgaaggag gaaaatcatg 2658781 attaatgtac taatagttga agatgacccc atggtgggtg aattaaataa acgatactta 2658841 agccaaatag atggctttca gctgaaaggc atcgcttctt cctttcaaag cgctctgcat 2658901 attttagggg agcaccatat tgacctcatt ttgcttgata tttatatgcc gggaaaaaac 2658961 gggctggaac tgctgacgga attgagagcc caaaatgaag cggttgacgt gattgtcatc 2659021 tcagcggcca gcgagcttga cgtgatcaag aaaacacttc ggtacggagc tgttgattat 2659081 ttaatcaaac cgtttgaatt tgaacgattc caaacggctc tgtctgatta cagacgaaaa 2659141 caaaaggtgt attcaaccca tcgcaacatg agccaaaaag aactggacgc cgagcttttt 2659201 caaaagaaag aagcaacaga aaaagtgcag cttcctaaag gcctgacaaa aagcacgctg 2659261 aagctgatct ggtccagtat ccagtcattt gaaaatgaat cttttacgac agaagacttg 2659321 gcaaagcaca cagaaatctc tcaagtatcc atacgaaaat acttaaagtt tcttgaagat 2659381 atacaggttc tgaatgtaga aatggcgtac ggaacgatcg gaagacctgt gtttcagtac 2659441 aacgtcaaca acagtaacat taacggaata aagcaatatc tataagaaaa cgcactgctt 2659501 gctttgagca gtgcgttttt ctgtcatatc tcttgccaag atgcttgatt ctattgttga 2659561 taagttatac aagaataaca aagggctttc acatttttaa gcaaataatt ctaaaaatag 2659621 ataattttta aaaaattatg cgaaattcta tttatttctt attagttaaa tgataaatta 2659681 tgattggtta gttgatcccg aaaaactaag tcataagtct tacttcagaa aacgatgtca 2659741 cggttttccg cccggaacgc cttccgcatc cttctcttcc ccgcctttcg aaggaaatac 2659801 tcacaccacg cttattcagg gaagaataga actgtctcag cgcattccat ttgttattat 2659861 cagaaaattt tatcgattct aagaaattgt tcaggacagc ccatcacatg actggccgga 2659921 tcagctttga accaaatttt tctggggggt tatatcttga ataaacgaaa aatcggattg 2659981 gcgatgtcac ttgtgatcgc agcaggcacc atattaggag catgcggaaa cagcgaaaaa 2660041 agcagcggct caggcgaagg caaaaacaaa ttcagtgtgg cgatggttac tgacgtaggc 2660101 ggagtggatg acaaatcctt caaccaatca gcctgggaag gcatccaagc ctttgggaaa 2660161 gagaatgggc tgaaaaaagg caaaaacggt tacgactatc ttcaatccaa atctgatgca 2660221 gactatacaa cgaacttaaa taaattggcg cgtgagaatt ttgacttaat ttacggcgtc 2660281 ggctacttaa tggaggattc aatcagcgaa attgctgacc agcgtaaaaa tacaaacttt 2660341 gcgattatag atgctgttgt cgataaagac aacgtcgcaa gtattacgtt taaagagcag 2660401 gaaggctcat ttctcgtcgg agtggccgca gccctatcaa gcaaatcagg aaaaatcggc 2660461 tttgtaggcg gcatggaatc agagttgatc aaaaaattcg aggtcggctt ccgtgccggc 2660521 gtgcaagcag ttaaccctaa agccgttgta gaagtgaaat acgcaggggg tttcgataaa 2660581 gccgatgtcg gtaaagcaac cgccgaaagc atgtataaat caggcgtaga tgttatttat 2660641 cactctgcgg gcgccactgg cacaggcgtc tttactgaag cgaaaaacct gaaaaaagaa 2660701 gatccaaaac gcgatgtctg ggtcatcggt gtcgataaag accaatacgc agaaggccag 2660761 gtagaaggaa cagatgataa cgtcaccctc acttccatgg tgaaaaaagt agatacagtc 2660821 gttgaagatg taacgaaaaa agcgagtgac ggaaagttcc cgggcggcga aacacttacc 2660881 tacgggcttg atcaagacgg agtcggcatt tctccatcta aacaaaatct atcggatgat 2660941 gtgatcaaag cggtcgataa atggaagaaa aaaatcatcg acggattgga aatcccggca 2661001 actgagaaag agctgaaaac cttcaaagct gaataagaat cgcagggata aggaggtcga 2661061 gcccttatcc cttgtttttc ttttattttg aaataaagga gcggtcaatc aatggaatat 2661121 gtcattgaaa tgctcaatat ccgcaaggcg tttccaggta tcgtcgccaa tgacaatatc 2661181 aatcttcaag tcaaaaaagg cgaaatacac gcgttgctcg gtgaaaacgg agcggggaaa 2661241 tcaacattga tgaatgtcct tttcgggctg tatcagccgg agcggggtga aattcgggtg 2661301 cgcggcgaga aggtgcacat caacagcccg aacaaagcga atgaccttgg aattggaatg 2661361 gtgcaccagc actttatgct tgttgacacc tttacagttg ctgaaaatat tattctcggg 2661421 aaggagccaa agaagtttgg cagaattgac cggaagcgtg ctggccaaga ggtgcaggac 2661481 atttccgatc gatacggcct gcagatccat cctgaagcaa aagcagctga catatcagtc 2661541 ggtatgcagc agcgcgcaga aatattaaaa accctctacc gcggtgccga cattctgatt 2661601 tttgatgaac cgacggctgt tttgacgcct catgaaatta aggaactgat gcaaattatg 2661661 aagaacctgg tcaaagaagg gaagtccatc atcttaatca cccataagct gaaagagatt 2661721 atggagattt gtgaccgcgt tacggttatc cgtaaaggaa aaggcatcaa aacccttgat 2661781 gtccgtgata caaaccaaga cgaactcgcc agtctaatgg tcggccgtga ggtatcgttc 2661841 aaaactgaaa agagagctgc tcagccggga gcggaagtgc ttgcgattga cggcataact 2661901 gtaaaggata cccgcggaat agagacagtc agagatttgt ctctttctgt caaagcggga 2661961 gaaatagtcg gcatagcagg cgtcgacgga aacgggcaat ctgagctgat cgaagcggtg 2662021 acaggactcc gcaaaacaga ttcaggaaca atcaccttaa acggaaaaca gatccaaaac 2662081 ctgacgccaa gaaaaatcac tgaatccggg atcgggcata ttcctcagga tcgccataaa 2662141 cacggtctcg tccttgattt tccaatcgga gagaatatcc tgctgcaaag ctattacaaa 2662201 aagccgtatt cagcattggg cgttttacat aaaggcgaaa tgtacaaaaa agcacgcagc 2662261 ctgatcactg agtacgatgt cagaacgccg gatgaatata cacacgctcg ggcattgtca 2662321 ggcggaaacc agcaaaaagc gattatcggg cgggaaatag accgaaatcc tgatttatta 2662381 attgccgccc agccgactcg cggccttgat gtcggagcga ttgaatttgt ccataaaaag 2662441 ctcattgagc agcgtgatgc cgggaaagcc gttcttctcc tctcgtttga gcttgaagaa 2662501 attatgaatc tcagtgacag aatcgccgtt atttttgaag gacgcattat cgccagcgtt 2662561 aatccgcagg aaaccactga acaggagctt ggtctcttga tggcaggaag cacgcaaaag 2662621 gaagcgggga aagcaaatgg ttaaacgact ctctcattta ctcgtgccgc tcatcgcaat 2662681 catacttggt cttgcggccg gcgcgttgat tatgcttgtg agcggctaca gtgtggctag 2662741 cggatattcg gctttgtgga atgggatatt cggagaaatc tattatgtcg gagaaacaat 2662801 ccggcaaatt acgccttata ttttatccgg attggctgtc gcctttgcat tccgaaccgg 2662861 actctttaat atcggcgtcg agggacagct gctcgtcggc tggacagcag cggtttgggt 2662921 cggtacggcg tttgacggac cggcatatat tcacttgccg ctcgcattga ttacagcggc 2662981 agctgcagga ggattatggg ggtttattcc cggcattttg aaagcgcgat tttacgttca 2663041 tgaagtcatt gtcaccatta tgatgaatta tatcgcgctg cacatgacca attacatcat 2663101 ttcaaacgtc ttgacagatc atcaggacaa gacggggaaa attcacgaat ccgcctccct 2663161 ccgctctcct tttcttgaac agatcaccga ttactcacgg ctgcatttgg gaatcatcgt 2663221 tgcccttctc gcagcagtta tcatgtggtt tatcatcaac aaatctacaa aaggatttga 2663281 gctccgggcg gtcgggttta accagcacgc ttcccagtat gccggcatga gcgtgcggaa 2663341 gaatatcatg acctccatgc ttatctccgg cgcttttgca ggtcttgccg gagccatgga 2663401 gggcctaggg acattcgaat acgcagcagt gaaaggcgca tttaccggcg taggctttga 2663461 cggtatcgct gtcgctcttc tcgggggaaa cacagccgta ggcgttgtac tggcagcatg 2663521 cctgcttggc gggctgaaaa tcggcgcatt aaatatgccg attgaatcag gcgttccatc 2663581 agaggtcgtt gatattgtga ttgccattat tattctattt gtggcttcaa gctatgcgat 2663641 tcgtttcgtc atgggcaaat tgaagaaaaa gggggcgaac taagtggaca ttgtgcagat 2663701 tttatctatc attgtccctg ccacactcgt ctatgcggcc ccgcttattt taactgctct 2663761 cggcggcgtg ttttccgaga gatcaggtgt ggtgaatatc ggcctagaag gcctcatgat 2663821 tatcggggcg ttcaccagcg tgttatttaa tttatttttt ggtcaggaat taggtgccgc 2663881 cgcaccttgg ctttcgctcc ttgccgccat ggcagcaggc gccctgtttt cactgattca 2663941 cgcggcagcg gcgatttcgt ttcgcgccga ccagacagtc agcggtgtcg ccattaacat 2664001 gctggcgctt ggggcaactt tatttatcgt caaactgatc tacggcaaag cgcagacaga 2664061 caaaattcca gagccttttt ataagacgaa aatccccggt ttgggcgata ttcccgtctt 2664121 gggaaagatc ttcttttcgg atgtctatta tacgtctatt cttgcaatag cacttgcctt 2664181 tatttcctgg tttatcttgt tcaaaacgcc gttcggcctt cgtatccgtt ctgtcggcga 2664241 gcatccgatg gcggccgata cgatgggaat caacgtatat aaaatgcgct acatcggcgt 2664301 gatgatcagc ggattgttcg gcggtctcgg cggcggcgta tatgcctcca caattgcgct 2664361 tgatttcacg cactctacca tctccgggca aggttttatc gccctggcag cgcttgtatt 2664421 cggaaaatgg catccgatcg gagcactggg ggccgccctg tttttcggat tcgcccaaag 2664481 cttaagcatc attggatcgc tgctccctct ttttaaagac ataccaaatg tgtatatgct 2664541 gatggctcct tatatcttaa cgattctcgc tttaaccggc tttatcgggc gggcagatgc 2664601 gccaaaagcc aatggcgtgc cttatattaa aggaaaaaga taaacattct cccctgggaa 2664661 gacgattctc agggattttt ttctaatcca aaagaccccc ttaatttaat tgtttattag 2664721 ttttttaact taaaaaaata tgaagtgtta acgctttctt gtagactgta acaaacaata 2664781 catgggggtg tatgacatgg gagcaattcc aaaaacgggg acaatttcac ctgagcaaaa 2664841 agactcacag gagaaaaacc tgtttcaaaa aatttggtct tgggaaatcg gtgtgattcc 2664901 tttgccatta tacacagtat tagctgttat tattattctt gcagcatatt acaatgagct 2664961 gccggcaaat atgcttggcg ggtttgccat cattatgatt cttggtgtgt ttctcggaga 2665021 cataggccaa cgcataccga tattgaagga tattggcggc cctgctattt tatctttgtt 2665081 tgttccttca tttttagtct tttacaatgt actgaattca acatctttag acgctgtaac 2665141 caacttgatg aaaacgtcta acttccttta tttctatatc gcttgccttg ttgtgggaag 2665201 tatcctcggt atgaacagaa ttgttttaat acaggggttt atcagaatgt tcgttccact 2665261 ggttgcagga acgatcgcgg ccgttgcagc cggcatcctt gtcggattta tttttggcta 2665321 tagtgcctat gattcctttt tctttgttgt tgtcccgatt attgccgggg gaataggtga 2665381 agggattttg ccgctttcaa tcgcctattc acaaatactg ggctcatccg ccgatgtatt 2665441 tgtgtctcag ctggtgccag ccgcaattat aggaaacgtt tttgctatca tatgtgcagc 2665501 cttaatgaaa aagcttggcg acaagcgtcc agatctaaat gggaacggac gtctcgtaaa 2665561 atctaaaaaa gcaaatgaga ttttcaatca aaaagaagcc gaagcaaaaa ttgattttaa 2665621 actaatggga gcaggagttc tgctcgcgtg tacattcttt atttttggcg ggttattgga 2665681 gaaattcatc ttcatcccgg gcgcgatctt aatgattatt tcagctgcgg ctgtcaagta 2665741 tgcaaatatt cttccgaaaa aaatggaaga aggcgcttac cagctttata agtttatttc 2665801 ttcaagcttt acatggccgc tgatggtcgg tctcggcatc ctctttattc cgttggatga 2665861 cgtagcgtct gtgatttcta taccgtttgt catcatctgt atttcagttg ttatcgcgat 2665921 gattggttct ggatatttcg taggcaagct gatgaacatg tatccggttg aatccgcaat 2665981 cgttacctgc tgccacagcg gtctcggcgg aacgggtgat gttgccattt tatcggcatc 2666041 aggaagaatg ggccttatgc cgtttgccca aatttcaacc cgtctcggcg gtgcaggcac 2666101 agttatttgc gcgacagtgc tgcttcgttt tttcacttca taaacagaaa gagttccgtt 2666161 ttatgcggaa ctcttttttt atttattcac aatccgaata tactctcggg gaccaaacgg 2666221 cagatccttt gattccgtct cactcattct ggctgacagg tggtgctcca gtaaatacag 2666281 ctcccactca tcacaagccg ccacaccgct gcgcccgtca tattgattca acatgaatgc 2666341 ccctgcaaat actgagcaga ataaacctga gcacatcacg acttttgttt tcacatgacc 2666401 agctcctttc cttcagcttg atcaggattg attttaaata tacaaataac ctcttttttg 2666461 ttagacttat tttgaggtca aaagaactca taaaaatcca ttacagcagt tcgaagcgtg 2666521 gcagcttgca gaaaagtgcg atataatttg gactaggtcg tttgaccgta tattttatac 2666581 atagcgcatt tttcaattga gaacgagaaa aggaggtctt atctttgcag ctcttacatc 2666641 ttgctatttt atcgcctttt ttatttgctt ttatcattcc cttcttggca aaatacgcaa 2666701 aaagagtgca tacgggctgg tttgtgttga tcctgcccgt cttgctgttt atatactttc 2666761 tcccaatgat caggatgacg caatctggag aaacacttcg atcggtatta gagtggattc 2666821 cgtcactcgg cattaacttt accgtttata tagacggcct cgggttatta ttcgctttac 2666881 tgatcacagg cattggctct ttggtcactc tttacagcat tttttattta tcgaaagaaa 2666941 aagaacagct tgggcccttt tatgtctact tattgatgtt catgggcgcc atgctcggcg 2667001 tcgttctagt agacaatgtc atggttctct acatgttctg ggagcttaca agcctttcat 2667061 cctttttgct gatcggctat tggtataagc gggaaaagtc gcgctatggc gcagccaaat 2667121 cacttttgat tacggtcagc ggcgggctgt gcatgctcgg cggatttatt ctcctttatt 2667181 tgataacgga ttccttcagt attcgagaga tggttcacca ggttcaatta attgccggcc 2667241 acgaattgtt tatcccggct atgattctca ttttattagg ggcttttacg aaatcggcgc 2667301 aatttccttt ttacatctgg ctccctgacg cgatggaagc tccgacgcct gtcagcgctt 2667361 atctccattc agctactatg gtaaaagccg gcatttatgt gattgcgaga ttcagtccta 2667421 ttttcgcctt ttcagctcag tggttttgga tcgtgtccct cgtcggcctc tttacgatgg 2667481 tttggggttc attccatgcc gtgaaacaaa ctgatttaaa atcgattttg gcgttttcaa 2667541 ccgtcagcca gctcggcatg atcatctcca tgctcggagt cagtgctgcg gcccttcatt 2667601 acggacatac agaatattat acagttgccg ctatggctgc cattttccat ttgatcaacc 2667661 acgcaacctt taaaggaagc ttgtttatgg cagtcgggat tatcgatcac gaaacaggca 2667721 cacgggatat ccggaagcta ggcggcctga tggcgattat gccgattact tttaccattt 2667781 ccttaatcgg gacattttca atggccggcc taccgccgtt taacggattt ttgagtaaag 2667841 aaatgttttt cacaagcatg cttcgcgtga cacattttga cctgttcaac gtgcagacat 2667901 ggggcgttct gttccctctt ttcgcctgga tcggaagtgt atttacgttt atctacagca 2667961 tgaaattgct gtttaaaaca ttcagaggaa attaccagcc tgaacagctt gaaaaacagg 2668021 ctcacgaagc gcctgtcggt atgctcgttc caccggtcat tcttgtcgct ttggctgtca 2668081 gtctcttctt tttcccgaat atattgtcgt acagcctgat agagcctgcg atgaactcaa 2668141 tctatccgac actgcttgac ggccatgaga aattccacgt tcacatttca cagtggcatg 2668201 gggttacaac ggaattgctc atgactgcgg gtattgttgt gatcggaaca attggttatt 2668261 tgtcgctgaa taagtggaaa ggaatctata aactgtttcc ttcgaaactc acactcaacc 2668321 ggttatacga taagcttttg actatgatgg agaaaggctc ttaccgggtc acaaaacaat 2668381 atatgaccgg gtttttaaga gattatttgc tgtatatctt cgctggtttc atcattctga 2668441 taggcggagc ttttgccatt aaaggcggat tttcatttaa aacggaaggc atggctaaaa 2668501 tcggtgtata cgaaatcatt ttgacgcttg tcatgatcag cgccacagtg gcgactgttt 2668561 ttgctaggtc aagactgacg gcgatcattg cactcggtgt tgtcggttat acgcttgcat 2668621 tgttttttgt cattttcaga gcgccggact tggcattgac tcagctcgtc attgaaacga 2668681 tttctgtggc actgtttctg ctttgcttct accatttgcc gaaactgagg ctgaaaacaa 2668741 aaacgagaac gttccggatg acgaatttta tcatttcttt aggcgtcggt gttatcgtta 2668801 cactgctcgg catcgcatcc tcaagccagc ggacaaaaga cagcattgcg tccttctttg 2668861 tcaaacacag ccacgatctc ggcggagggg ataatgtcgt caatgtcatt ctcgttgatt 2668921 tcaggggatt tgatacaatg tttgaaatta cggtattaac gatagccgct ctcggcattt 2668981 acagcatgat taaaacaaaa gtaaaagagg aggggaaaag cggtgaatga acaaaaaaca 2669041 aatgacttga ttcttcaaac cgcgacaaag cttgtatcct ttatcatttt gcttttctct 2669101 ttctatttat ttttatcagg gcataacgcg cccggaggag gctttgtcgg cggactgatc 2669161 acgtcctctt ccatcgttct cttgctcttg gcatatgatt taaaaaccgt gcgttccctt 2669221 ttgcctgtca atttcattta tgtcgcggga gccggccttc tgctcgctgt attaacaggc 2669281 gttggctcct ttgtcttcgg ggctcctttt ttaacccaca cattcggata ctttcagctg 2669341 ccgatccttg ggaaaacgga gctcgccaca gcgacgatat ttgatttagg cgtttatctt 2669401 gttgtcgtag gcataacgat gaccattatt caaacgattg gagaggaaga ataatggaaa 2669461 tcttaatggc tgtattagcc ggtattattt ttatggctgc tacgtatttg ctgctgtcta 2669521 aaagcctgct tcgcgtcatt atcggaacag cactgttaag ccatggcgtt catttaatgc 2669581 ttttgactat gggaggatta aagaaaggcg ccgctccgat tttgagcgag catgccaaat 2669641 catttgtcga tccgcttccg caagccctga ttttgaccgc aattgtcatt tcttttggcg 2669701 ttacgtcatt catcctcgtc atggcctttc gcgcttatca ggaattgaaa tcggacgata 2669761 tggatcaaat gaggggaaat gatcaacatg aataattttg ttattttgcc aatcctgatc 2669821 ccgcttttgt cggctattct tctgattttc atgacgaaga atcttatgct catgagaatc 2669881 ttcagcacgg cggcatcggc catcgggatt gtgattagcg gcatacttgt acagactgtc 2669941 ttcacaaaag gcatccagac actcagccta ggcggatgga aagcgccgta cggcattgtg 2670001 cttgccgcag accaattcgc cagccttctc gttctcacaa cagcgatcat cggtttattg 2670061 gttgggcttt attccttccg ttctgtcggt gaaaaacggg agcgctcctt ttactactcc 2670121 ggcgttcagt tcttgcttgc cggcgtcagc ggagcgtttt taacaggcga tttatttaat 2670181 atgtacgtat tttttgagct tctgcttatt gcttcctata tgctgattgt attaggcggc 2670241 acaaaaattc agctgcggga atcccttaaa tatattgtgt ttaatattgt atcgtctgcc 2670301 ctgtttgtca taggggtcgg ctttttatac gctgtaaccg gtacgttaaa catggcggat 2670361 cttagcgtga aaatcagcga atcaggacaa accgggctga tcactgtgat tggtgtcctg 2670421 ctgcttttgg tatttggcat gaagggcgga atcttccccc tctacttttg gcttccaggc 2670481 tcttattacg cgccaccggc ggcaatctcc gcgttgttcg gcgctttgct gacaaaagtc 2670541 gggttatatg cgattacgag ggttttcaca ttgattttta ttcacgatac agcctttacc 2670601 catcagttga tgatttggct ggcggcgctg actgtgattt ttggtgtgat cggttcactc 2670661 gcttattcga atgtcatgaa aattgtgatc tataacatta ttaccgctgt cggcgtgatt 2670721 ttgttcggtg tggcagtaca cacccccgca tccattcagg gcgcgatcta ctatctgatt 2670781 cacgatatgc tgattaaggg cgctttgttc atgctggcag gtacgctgat cgcattgact 2670841 ggaaccgcga gcctgcataa aatgggcggg ctgatcaaac gctatcctgt tcttggatgg 2670901 atgtttttca tttccgctat ttctcttgca ggcattccgc cactgagcgg atttgtcggc 2670961 aaatttaaaa ttgcagaggg cggcttcgca gaaggtgaat ttacgatatc catgctgatt 2671021 ctgctttcga gtctgcttgt actgtactct gtgctgagga tctttataca tgcgttttgg 2671081 ggcgaagaaa aagaaacgcc aaaaccaaat catcgaacag ctaaaggact tctttatccg 2671141 gcagctattt ttctcttgct gtcccttctc ttcggattgg gtacagaatg ggtgtcgcct 2671201 tacgttgatc aagcggccga gacgctgctg aatccggaaa aatatatcga agctgttctg 2671261 aaggagtaga tcgcatggca tttcaaattt tattaaatgt gtttctcgct ttttgctgga 2671321 tgttcttaag caacagtcca agcgccgcag gattcattac aggctatatt ctgggaatgc 2671381 tctctctctt tttcttccgg cgctttttca ctcgccagtt ttatctatgg aaattgattt 2671441 ctattatcaa gctctgtttc atttttataa aggaactgta ccttgccaat gtcagtgtga 2671501 tgaaatcagt cttatctcca aaactgaata tcagaccggg tatttttgct tttaaaactg 2671561 aactgacgaa ggactgggaa atcaccatgc tttctctgct cattacatta acgccgggaa 2671621 ccttggtgat ggatatttca gatgacagaa caatacttta tattcatgca atggatatcg 2671681 aggatgcgga aaaagcgatt tttgacattc gggagtcatt tgaaaaagcc atacaggagg 2671741 tgagccggtg atgtttacgc tgatcctgca aatcgcgctc ggcattatgg cagtgtctac 2671801 ctttttgtat gtcattcgtg tcattaaagg tccgactgtg cctgaccggg tcgtggctct 2671861 ggatgcaatc ggcatcaatc tgatcgcaat cacggcgctt gtctccattt tgctgaaaac 2671921 aagtgcgttt ttggatatta ttttgttgct ggggatttta tcgtttatcg gaacgatcgc 2671981 attttccaag ttcctggaga aaggagagat tatcgaaaat gatcgaaacc gctaaggtcg 2672041 ttgtggctgt attcattttg ctgggtgctc ttatatgcct cattgcttca tttggcgtac 2672101 ttcgccttcc cgatgtgttt acacgcgctc atgctgcttc taaaggctca acattaggtg 2672161 tcaatatgat tctgctcggt gtcttcttct atttgtggtt tgtgacgggg gagctctccg 2672221 ctaaaatcct gcttgggatt ctctttatct ttattacgtc gcctatcggc gggcacttga 2672281 tctgccgtgc tgcgtataac tccggcgtca agcttgatga gagaagtgtg caagatgact 2672341 ataacggaat cagaaacttt gtgattaaac gaaaagagga ttcttattta taaaaataag 2672401 cagccggaca ggcagagttc cggctgtttt tttatttctt gatgacagcc agcgtgcatc 2672461 tggatataca gatcagcctc tcttgctcgt catatatgtg aatatgatag acaatcgtcg 2672521 ttctgcctat atgaacgggc tcggctatcg cctttaccgt tccttccttt acagatttta 2672581 aatggttggc gttaatctcc aaaccaacac aagcttgcgt tgtatgatca atcaggttct 2672641 gtgcacctgc gctcgccgcg gtttccgcca gggccactga agcgcctcca tgcaaatatc 2672701 cgaacggctg taccgtccga tgatccaccg gcatgaccgc aacgcatcgt tccgctgtgt 2672761 tttcaacaat ctcaatacca agcgcttcaa gcaatgtgtg cttcatatcc atctctacac 2672821 cccccaacat ttaaagtaca ccgtctgatt tcgcaatcaa aaccgcttcc gtccgtgaac 2672881 cgacattcag cttattgaaa atcgatgtca agctgtattc aatggaccgc ttgcttaaat 2672941 gaagggcatc tgcgatttct tggtttgtaa atcccttttc aacttcttga agaatcaggc 2673001 attctctagg tgtgagcaca tcttgttctt tttgagagga aggagccggc tttgtttttt 2673061 gctgagtcat cagctgttta aagtaagcaa aatcgactaa aatttctccg ttgagtacgt 2673121 ggtatatgta ttgggtgatc ttttctttag attccgtttt gctgatggca ccgtgcagac 2673181 ccgcacgaat cgcttcctcg aaataatcct cgacctcata accggtatac acgataattt 2673241 tacaatgagg attctcttgt aaaatctgtt tagaaagctc catcccattg acctcgccgc 2673301 ctagattcag atccattaaa atgagatcat atgacgagaa atcatgctgc ttgataaact 2673361 gttcgctcgg ttcaggactg agacaatcaa cagacaaatt cgaatccgtt tccaaaattg 2673421 tcttggtgcc ttccatgaca gccggatggt catcaatcac tagtatcttt ttcatgtttt 2673481 cctccctttt actcactctt ttccatttta taaaaaagac ttggcctgtg ccaagtcgtt 2673541 tccgttataa atccattaca attcgatttc aatatcagcc ttaaagccct ttccttcact 2673601 tgtttcaatc cgaaggcgcc catctaaagc cctgactctc tccttaatgc cagaaagccc 2673661 catgctcatg gaatgctcag tatttttttc ttgatcaaac ccaacgccat cgtcctcata 2673721 atgaagaacg attttgtttt gaatactgat gagcataatc agcacatccg tcgcctgaga 2673781 gtgcttgacc gcattagaca gaaactcttg aatgatccgg tacaaattca gctgcgaatc 2673841 cagatcaagg gaagccgtaa atctcccggt atttaaacgg atatgaaacg gaacccgctc 2673901 ctgctgctgc gccaccagct tcgacagcgc cttcaccaat ccaagatcat acagaagctg 2673961 cggccgcagc tcatgacacg tctccctcgt catcgaaatc acatcagaca tctgctcatt 2674021 catctgtaca agcttgtcct gcacctcttc acggcacgga ttatcatcct tcttgaaatc 2674081 acccaaaaac agctcacact ggcgttttaa ggaaatcaaa tcctgaagaa ccgaatcgtg 2674141 gagatcgcgg gcgagtcctg aacgctgttt ttcttcgatt gcaaacatta gctttttcag 2674201 ccagatgggg ttggttccct cttgttttaa gtccttcaaa tgttccatga gctcctcaat 2674261 atgcaggaca ttttccatgg acacacttgt ataaaaagac agtgttttca gccacgatat 2674321 ttcatcacgt gttagccggg gagtgttaat attagataaa caaagcagaa cataagaact 2674381 accgcctcgt tcaccaactt tcataagaaa gccttgattg acttctataa ttttcccaat 2674441 ttctgaagtt acgttttcaa attcctcttg ataaaaattc cagtccggtc caacttcatg 2674501 cttatctaaa aatatcactt tgtgatcagg agtaacctca aaggtataag ctttgcttac 2674561 aagcaaaaca tccagtatag tatttttcag ttctttaaaa acttgttgaa gagaagttac 2674621 acccctcatt agctgagtat atttaaaaat actgtcctga tagttgaatt tttcggagaa 2674681 acgttttaac cgaaatttaa aatccatgac ctctttaaaa taaaagacag cgaacatgac 2674741 aacgaaaaaa aatacagttt gacgcacagg gttcatctgg atgtccatta catcaaacag 2674801 aactaatgca ccaactatta gaagagttgg tatcatggca agtagagcat agtatctcat 2674861 tcttcctaag ataaactcta tatcaaacat cttattggct acaaattggt atactaaccc 2674921 gaacggaatt agtactagta atgacgccga agctaatgcc gggaaaatat aattacctgt 2674981 aaatattatt ggaagaacaa aaaatatcaa aaaaggcgca aatgaaagag tgtttgttaa 2675041 aattagtaat ttaagaataa acgaatgctc agcatattta tatttattaa gatgtaagta 2675101 tatcgctgaa aaagaaaata gagtcaaagt tgcaaaagaa accaaattaa gagttgctaa 2675161 aaaatcaata tctacttgta aatagtcttg aaaaaactca ataccaagat taaatattgg 2675221 tatgatataa agaaaagaaa ttctattcaa aaaagtttta cctatttctc caaggtatct 2675281 ttgtataaat tgaagataaa gaataggaga agatataaaa gtaaacaagt taatataccg 2675341 attgattata tgtcctctaa atggtccgcc tgcacttata tatgctatcg aaatgtctaa 2675401 taacaataga ataagaatat aggcagcaaa tgatctcctt tttttattta ctttaagtat 2675461 ataaaaaata catattatgc ttaaaaaata aaaaaacaaa ggaagtacga acagaaaaaa 2675521 actataaggt ctatttagag taactaaatc aaaatctttg agatgaatct tttttccact 2675581 tctcaaaata tccagactgt taatatgact caaatatccc catttcaaat gtttgtctga 2675641 aggtttttct ttattaattt ttaatatgat gtctccctgt ctcagaccaa caaattgtcc 2675701 atatgaagat tccgatattt cttctatcat aaattgactt ttatcatttt tatgaatctt 2675761 agtcccaata ataattccat tcatactgat ataagttgta tagcttatat aaaggatact 2675821 caaaacaatt acagctattg tgaatttttt tattaagttc ttcaatatta atccacctat 2675881 taatcacccc attgacgggt tattggatca gccagataat aatcattata agctttaatt 2675941 attgtttcag tttcttgcac atcaaaacct ataaggcagg cttctttatt tttcaatttt 2676001 tttaaagcct caggataatt taaaaagtag ttaattaggt cttgcatctt gtatccccct 2676061 ttgtataact taataagcat tcctttatta gctctttttt tctttatcta aatttaattg 2676121 ttctatagca gaaatacatt tctgtttata tatttccaat aataccgaaa tgtattgagt 2676181 aactcccgct ttaattaatt tttcttggaa tttctcttta tcaagtaacg atttataata 2676241 taagtcttta tgtgaaatta agtataataa atcttccgaa gcatcattaa aaaggcgctt 2676301 aagatataag taaatcagtg tatgtttgtt tttttcaata tcactgcgat ttccggataa 2676361 aagaacataa taatctccag aaatttgagc tataatccct ttatagtagg aatatctttc 2676421 aactgtttca ttatattctc ctgtagccaa taaaacacct gctacatttg ctagtgcaat 2676481 cagacttcca cattttaatc taattacttc taaactttca tcttctgttt tagatttatt 2676541 agtgatatcg tcatgttgac cttgcatggc ctcgtttacg tattttaaaa catatttaaa 2676601 aattagagga ttgttattta atgaataaat actcgttaat cctactgtat acaaggaaag 2676661 tgctgcattt aacgactccg agcgattaat tttcatccat aatgcatggt gattatcttc 2676721 atcttcaaga tcatccataa tatctgatga aagaataaga atttctattc ccgcgccaag 2676781 ccttgttgca acatctaaat tctcccctcc aaaaacaaca taatgtaaga ttgtggattc 2676841 agcaaaggag aatgtttctt tagaatcaat aaatgagtaa agaagttgtg acaaatcctc 2676901 gttaaatatg ttttgctcca caatctcctt cattttctcc ttgatccgga cagaatctaa 2676961 acatatctgc tcaataacga cttcccccct cccattccat tttactaaat gggacattta 2677021 aaggacagca ggtttttcgt tttttaacaa tcatataata ctttatccat ttattgtatc 2677081 ggtagaacga aaaaaaagac ttgtttccaa gtctttttca cgaaattttc attgcataat 2677141 tgtatttatc gagttgatca atgcttttgt taatgtttcg taatgaatct gtcgtttctt 2677201 taatatcaag ttcgagtcgg aataacaatt gttttacttc ttcaagtttc ttttccatcg 2677261 tttccacact cctttttttg aaagatcaat gaattgtgta tggtgaacga gtcctaggta 2677321 tttgatctgt tactaatagt gtgtctgctt tcggctcatt tttcaccgaa aagtatgcaa 2677381 aaaagtcctg cgtgacaccg caaatctcaa taggtcctta tactcaaagg aatcacaaca 2677441 agaacgggac tatctttcta tgcgaaagag cgtttatatg tgctgaaatt gagaaagatt 2677501 cttaatctcc ttgattttaa cgggtttcgc attttcacta agcaagacta tagtccttca 2677561 taccgtattt tcaaaattga atatgcgatt cttggcgttt cctgaccgac aaacaccgaa 2677621 aaagaccgca acgctaaagt tgtggccttt tcgctttgtc atattcggca attagggatc 2677681 tatacatata gaaacatcct tttttgcgag gtgctcccat gagatatcgt tatccctggt 2677741 tttacgtgta tccgtatgag gtacgccgtc cgcccgctcc tgccaacaat attgatacct 2677801 ttatccgttc agcgaagcag gccgcaggga tatttgcgga tgcccagctc gttctcagcc 2677861 gcattgcggg ctcgcgggag ctttcgcgcc gcattctgac cgcagccgaa cagtctgata 2677921 aacaaactat aaggcgcctg atcaaacaaa tgggcgtccg gcatgaagtg gatacggtct 2677981 ttaatcccga cggcatctat atcagcctta tcggaacgca aagccgaatg attcttgctt 2678041 tgcggtggtc agaggaccgc aatcattttg cgtccataag attatgacac cattccagag 2678101 cctctaaata acattcatac gcttcttctt tgtccagttg attgcctaat tctgagcaag 2678161 tgtcccagtt gttgctttca attaatttca caagctcaag catttggtag tagtcgtttt 2678221 gatggcctaa taatgcttgc ccgacttcat cttttaaagg caattcttga acaatttcct 2678281 ctatttctct atgcaggagg gtgtctatga gagaaaacat tccgatcagc atataagaag 2678341 caggctgcgg ccgggatgtc tttctcgcca gcagttcgca aagctttgct cttatcagag 2678401 aaatcttaat gatttcgtgc ttgctggaat gccctttcct gcttaaatcc ttaaaggaaa 2678461 gaatatatat ccaccgtttg atttcattaa atcccagcag cataatggcc tgttgaatgc 2678521 tttcaatttt ctggctcaaa cggctgtggg atgagtttaa aaattttaaa atttgatagg 2678581 acagtgataa atcccgctct atgtactctg tcacacgctt tatgttaggc tgctctttac 2678641 tcagttcgtt aagcagttca tagtaagaat agaaatgagt cgataggtca tgcccgctga 2678701 tgatgcgcgg ctcgctgaaa aagtagcctt ggaataattg aaagccgtct tggaccgcct 2678761 gtttatattc ttttcgggtc tctacttttt ccgctaaaaa aatcaggccg cggcagccgt 2678821 aggtttgcaa aattgttctg cgttccattc gtgttgtttt gagaaaatca attttcaata 2678881 tatcaatata gctcatgagt ttttccagta agtcctcatc ttgcggattt attgcataaa 2678941 aatcatcaag cgccagcata taccccattt ttttcaattc tttgcatcta gaaatgaggg 2679001 ccggcgtgat cggtatatct tcaaggattt caatgacaag ctgtttcgga ttgaaggagg 2679061 tgggaagatt cgaaaacatc aggctttccg taaaattaac aaaacagcgt ttcccttccg 2679121 tcagcttctc aattccgatg tttaaaaagc tgttgatcac caaatctgtt gttgcctgat 2679181 cgccgtcttt agcgctatac acgttctctt cgctttctct atacagcagt tcataagcaa 2679241 caacctgttc ttttctatta aaaataggct gtcttgcaac aaacaccctc attgatttat 2679301 cccccttaca atacgcgcgg ctttcacccc taagtatatc aaataatttg acgaaaattg 2679361 tctaaacatg aaaaataata tatacataaa gaaaactggc ccttcgcgaa tgaaaggcca 2679421 gtttttcttt attcttcctc aagctcttct tcaattctgc ttttcacttc gtggatccgc 2679481 tgcattttat tgctccagca gtcctcgctt aaatcaaccg ggtattcctc cggcttgctg 2679541 attctcttat attcctccca aagcaggctg aggttatcct gcacatactg ctgtatgtct 2679601 gaaatctcag ggttttggta gcaaagaata cccttctcaa aaatcagttc atgaagatcc 2679661 ttcgcataaa aattcgtgac aaatttgctg atgaatgtat gaaccgggtg gaacattctg 2679721 agccgcttct gatcattcac ctgctcatca taaagcgcaa tatagtcgcc ttcagaatga 2679781 tggttggact gattaataat gcggtagact ttctttctgc ccggtgtcgt cactttttca 2679841 ggattggacg aaattttgat cgtgtcgacc attttcccgt cttcttcaat ggcaacgagt 2679901 ttataaactg cgccgagagc cggctggtca taggcagtga tcagcttcgt accgacaccc 2679961 cagacatcaa tgcgcgctcc ctgagccttt aaattcataa tggtgtgctc atccaaatcg 2680021 cttgaagcaa tcaccttcgc atctgtaaat cctgcttcat caagcatttt ccgggctttt 2680081 tttgacaggt acgccaaatc gccgctgtcc agacggatgc caatgaaatt aatgcggtcg 2680141 ccgaattcct tggcaaccct aatcgcgttc ggcatgcctg aacgaagcgt gtcatacgtg 2680201 tcaactaaga agacgcaatc cttatgtgtt tccgcgtatt ttttgaaagc tgtatattca 2680261 tcgcggtaag cctgcacaag cgcatgcgca tgtgtgccgg aaaccgggat attaaagcgc 2680321 tttccggctc ttacattgct tgtcgcgcta aagccgccga ttaaggctgc tctcgctccc 2680381 cacatggccg catccatttc gtgcgcccgt cttgttccga attcaagcgc aacttcatca 2680441 ccgatgacgc ctttaatccg ggcagccttt gttgcgatta atgtttgata gttcacaatg 2680501 ttgagcaaag ctgtttcaat cagctgcgct tctaccaggg gtgcctccac cctcataatc 2680561 ggctcattgt taaaaacgag ttctccttct ttcatggagt aaagtgaacc tgtaaaagat 2680621 aagccgcgca aatattcaat aaaatcttca tgatacccga gttcatcctg taaataactc 2680681 aaatcgctat ccgtaaactt gaaattttcc aagtattcaa tggctttttc caagcccgca 2680741 aatacggcat agccattttc aaacggaagc cttctgaaaa acagctcaaa aatcgctttc 2680801 ttttcatgaa tgccgtctct ccagtacgtt tccgccatat tgatctgata aaggtctgta 2680861 tgtaatgaca ggctgtcatc tttaaatccg tactctaaca ctgtttttcc ccttccttac 2680921 tctgccactt gcgctccgat gctgtttgca aaatgggaaa gagcccatgc gtgcccctcc 2680981 tgattaaagc tggcaacagc ttgtttatgc acaacaatcc gaaaaccttt gttgtatgcg 2681041 tcaacagctg tatgcaacac acaaatatct gtgcagacac cggcaagatg cagttcgcca 2681101 atctgccgct ctctgagttt gagctctaaa tcagttcccg caaaagcaga atatctcgtt 2681161 ttttccatgt agtaaacatt aggttcatgt tcatgtttct gatatagagg caaaagcttt 2681221 ccgtacagat cttttccttc cgtgcctttt atattatgcg gaggaaaaag acgggtttca 2681281 gggtgatatt gatccccttc atcatgagaa tctactgcta atacgacgta atcaccgttt 2681341 gtgatgaatt ctttagttaa attgacgatc gcctcttcaa tcattctgcc gggctccccg 2681401 caggtcaatt ttccgtcact cgccacaaaa tcattcgtat aatcaataca aataagtgct 2681461 tttttcatag ccggcctccc cgccatcagt atgagaacat tatatcttat ctccagttgt 2681521 aagtgaattg ccatgaacaa aaagacaaac ggtccgtttg tctcttacga tttcagtact 2681581 gaccgattat aaatgtcgtc ctgaatatat atcaattcac gattcacagc gatatcagcc 2681641 gcaatgacga tgcctaaggg cgtatgaaac tggagatcag atacaatctt gaaaggcact 2681701 ccgtaccggc tcgccatttg gatataagaa gagtaagact gatactgaag ctctccatta 2681761 atcaaaaggg tgacgttatg gctgtttttc agctcgtgct ctgcctcttt atacggtttg 2681821 cttctaagca cctgtccttt cgtcagtgcc aaaacgactc tttctcttaa agagcctaaa 2681881 aacaaatggc gctcgtcagg ctttgtctcc aaaggcccat acattccttg ctgcaaatag 2681941 agatccattt tatcttcact caaaagcctg tcctcccgtc ttgtttgtct tcattatcac 2682001 ctgatcaggc aggagctaaa ctttcaagcg ccgtttacat ttctgttacc caatgaatga 2682061 tttttttggc cagctcacca gcaggggttt cctctgtatg ccggcgcaac gacgcttcca 2682121 gccgttcagg cagagttgct ttatcttctt cataggaaat gatcgtgctc cactccagct 2682181 gcggtaccgc tacaagcgtg cgcagttctt ttctgttttc atgcagatac acgtccgtga 2682241 tcattccggt ttgcgtattg atatttgctt ttctgatttt cataacatga cctctctatt 2682301 caaagactac ccatattata caataaaaaa gcaacagcct cttgtgaaaa ggctgttacc 2682361 cgttaaacga aactgtttca tcagtgatat cggcatcttt gaagagagtt ttactcgttt 2682421 ggttgttaat cttcacaaaa tcaccaagct gaaatgtgcc tgaccccgcc cctgaatgag 2682481 cgacgctttt gggcgaaatc gcaaatacgt ctccaaagct tgccgcggca ttatccgtaa 2682541 ctgacatgat ataaatcggc cccacaattg caggcatttc cccacctccg cattgattta 2682601 cagcatcata tgcaaggagc cgataatggt gcccgcctat tcagctggct ttgcgttttc 2682661 ctcgagtcgt gaccgctggc gcagcttgat caagcggaca atattcagga agaacgcctt 2682721 cactaccgca taaaccggca ccgctaaaat catgccgaga attccgccga agcttcccgc 2682781 tccgattaat agcaaaataa tcgtaagcgg atgggtattc agccgctttc cgatcacaag 2682841 aggagacagc aggtttccgt ccagctgctg aacgatgacg accacaataa tcgcaaacag 2682901 cgctttggcc ggcgagtcca taaaaccgac aatgacagcc ggcgcggcac cgagaaaagg 2682961 cccgacatag ggaatgatat tggtaatcgc catgacaatc ccaagaatca gggcatacgg 2683021 cagtccggca attaaatagc cgataaaaca cgctgttccg acaaaaagac agattaacag 2683081 ctgcccctgg aaatatgccg caagcgtatc ggataaatct ttaaaaatct ttaagccttc 2683141 tgtccgataa gaagccggta gaatttttac tgccaaatgc ggaaagcggt gtccgtcttt 2683201 cagcatgtaa aaaaggataa atggaacagt aataataaca agcgtgatgt ttgtcacgac 2683261 accaaacacc gcagataaac tggacgtgat attttgcggc aggttttgga gaaaacttgt 2683321 caatgactgt tcaatttttg atatcgatac ataatcctgg ttcatcatcc aggtaaacca 2683381 ttgagaatgg gacaaatcct ttgtcagcgc ctgaatctgt tttatataat caggaaggtt 2683441 gttaaacagc cctgtcacct gtgcggtgat gataggtccg actgacgctg aaataaaggc 2683501 aagcaaaccg ataaacagta aatagatcaa tagaatggat aatgtccgcg gaattttttt 2683561 ctcaagcagg cggacgaccg gattaaatat gaaatacaaa attcccgcaa ttagcatcgg 2683621 gaaaaacaat gtcgagataa aaacaataaa cggctgaaat acaaatgaaa cttttgttgc 2683681 tacaaaaata atcagcaaaa caaataaaat ctgcaatgtc caaaaatgga cttttgattt 2683741 caacaagctt tgttcctcct agtttttctt tgtctgtcag ataaaagaac ttatacccca 2683801 tcattgtaac aaaaatgaac tcatatcaga actcttaata taatgaaagg agtgttggtg 2683861 atgaaggccg tgacatacga tacagattca gaactggctt atatctatgt tcttcctccg 2683921 aaaaagaaca ggaatgtacg gactgaggag ctcagagtca atgattgtct cctgctggat 2683981 atcagccaag atggcaaaat cgccggattc gaatgttttg gtgaggcagc acacctctgt 2684041 gccccatttg ccgggaaatc ccggctgtat gtaaaagatt cagacggtta tcattttcgg 2684101 gtctgccagc atgcttcagt ccgttcctgc tatacggtgt accgtgtcac tttctgtttt 2684161 tcagatggtg actatcagga atttgccggc tttgaccttg atggaacaat gtatcatagt 2684221 gcgtttttac agcgcttaac tgaaaaatag gacgtcctgt tgtacgccta tttttcatgc 2684281 gcaagcactg ttagacccgc tcactgtaat ctggggtgac ggaaatcatg tgctggattc 2684341 tgatcaaaca aacagaattt cgggctcctt caattgtgat atggtcaggt tttacatcga 2684401 tcagtctgcc tctgaccgta tctcgtactg tctgtataac gaaccttgag ccgatgagct 2684461 ttttaatggt ctgatagaca taaggatcga ctaaagagac cagttgcgga ctaccttggt 2684521 tgaccatact tttatcccct ttgtgtgttt tatctcagct tatgccgcgc ttatggataa 2684581 tgacacaggc ttacctgata aaacaaaggg gtgcggagat tttaggagaa tacgtttgga 2684641 ggcgggtgta aaggaagtat cgatgaagcg gagacagcga agaaagctgg cgctgttccg 2684701 tacttataca ggctttatca cggatgcctg ggcttggtcg attaattggt ccagcttttc 2684761 tatttttttt cgtgcggttg aaggatcaat ttggcggtaa tgatggtggc cgcccggctc 2684821 ttcatccagt tcgtccgctt ttttgacaat ctgctgcagt gtgtttttat ctaattcgcc 2684881 ttcaggcaaa taggaatctg tatgaagcaa aatggctagt gcaatctctt ttgctgcttt 2684941 cggttcctcg ccaagccgaa tcagaagttt atgcgcccgt tccgcccctt taatggcatg 2685001 aatgtcattt cttttgtatt tctcataatc ccactttccg tctgtatacc attcataatg 2685061 gccaatgtca tgaagcagtg ccgcttttgc tgctaaatca ggattaatgt cagccttcac 2685121 agacagcctg tatgcatgat aagcgcaggc aatcgcatgt gccacgccgg aacgctgaag 2685181 atatttttgt gcaattggat gggtgaaaac atccattaat gtaacctttc tcatggaaac 2685241 ccctccttta gatattttta gaatcctaac ataatttgca gagaaactca attcttatgt 2685301 cacatcattt tgatcttctt atcatcattg ttatacccta aaagcaacgt ttcagtcagt 2685361 atatgcggct gttcaataaa atgcgctggc tgcagccttt tgtataaaaa aaagagcaga 2685421 aaatatctgc tctacaaaaa ctctttaata tcataaatgc ggccgttttc cgtccctttt 2685481 tctagtaaag aaagcagcgt gccggcaata aagtccggac tgcgaaggct tcctgtttca 2685541 tttaatttcc ggaatcgttc aatgtggtgg aaatcctttt tcgatgaaga acggatgacg 2685601 gcctgcatct cagtgtccat cactccaggt gagaacgaaa tcatgttcac cggcagctct 2685661 tcatcctcct gttcaaatcc gaatgtcctc gtaaacatgt cgagcccggc ttttgaactg 2685721 caatacgcgc tccatccctt atatggattt ttggcggctc ctgaagtaat gttgacaacc 2685781 gtctttttgc cgctgtatga agcaaaccgt tttgtaaaca gctgactcaa aagcacgggc 2685841 gcagtcaggt tcagctgata atggcgctga agctcgtcaa gagacgcttc gccggcacgt 2685901 ttgatcggcg ttaccattcc ggcgttatta ataagggtaa taccagaata acgatctgaa 2685961 tcgatggatg agagcaatgt ttcaaattgc tgttcagctt cttcgagatt gatgaggtct 2686021 atttgatgct gcgttagttt tttgtgagag acatctgttt tcgttctgga taaggcatgg 2686081 acttcatgcc ccttttctaa agcctgtaat gcaatggctt gacccagccc ttttgacgct 2686141 ccggtgatga tataaagttc cattggaaac ctccttttcc gttattattg tacggcacct 2686201 cttttacaca acacaagcac gcggcctacg ccttcttgtt ttcctgcgct gtgacttttg 2686261 ggatgaggaa cacgatgcct gcaattccga gcaggatcag tacgacatag atcatcggca 2686321 gcagcaatga tgatgtttct tgttcatctt ctgtttccgt tgatgatgtc tttgtcattg 2686381 gtttttcagc aaaagtaatt ccaagctgtt tcgactgggc cgcaatcgtg ttggaatcct 2686441 cggcatttgt tgatgtaaac aaatctttta tcagctcggc gtccttgtcc ttcggtttat 2686501 caaaagtgat atccttttgt tcctcaggca gttctgtttt ttcttcatag taggtatctt 2686561 catgcaaata attcgtatcg atttcgatgt cttttttctc atactggttt ggcgcgacat 2686621 ctgtattttc ttcagtttgg gcagccgctg cagagggtat gaaaagggaa aaggagagca 2686681 tacaaatcat gatccccttt tccatgctgc gatcacgctt catacgtttc atcgctttct 2686741 gctgtgtgtt cagccatcaa ccggataatc agcggcagag ccacggcaat caccgtaatg 2686801 atcagcagaa ctgttattcc cattgtaaac aagtgcccag taccgtactg gatgtcgata 2686861 tatactttcg aaaccggatc ttcaaatgta aagttcggca tgatcaaatc aataagcggt 2686921 gcgacataga ataggatcat tgctgctgaa gcaacccagc cagggattga tccgaatctg 2686981 aatgccgtcc ggatgaaggc agagcttgcg accagcaata gaatcgtaaa caccgaccac 2687041 ttaatcgtct gatcgtccgg cagtgaataa atattcaagc cgaacaagct gatcataagt 2687101 ccgacaagga tattcagaat tccgaataac gctcctttga cgagaagcgg tgcgttttgg 2687161 taatacgagc tgaaatagcc gattaacaga ctgctgatca acacaatgac aaggatgaca 2687221 accggaggta ccgtctgaat tttttcttcc ggaacctctc cgctgatttt aagcggattc 2687281 gctaagtaat catatacata gccattgttt tgcccgtcta ctaatgtatt tccgagtatg 2687341 ccgtatacgt catttcgcac gagtttcgtg gaggcgacat ttttccccca gttgttgttt 2687401 aaggtgtcgg ctttcgcttg aacatcatta acgctttgct gcatgttggt tgtgtaatca 2687461 atgatgccgg actggcgatc agacaatgaa cccatcatgt ctgacatttg cagcacttcc 2687521 tggccgaccg tatcttggac actcagtgcc atggtaccag acagcccatc gttgctgaac 2687581 gtcgcagatt cctgtgttgc gcccgttaca agctgttctg acgcttttgc ggcactttca 2687641 gagattttcg tcagttcgtc gagaacacct gcttgagagt cacggatata gccgctgtag 2687701 tcgtccgcaa atttggtcat gccgtcgatg aagctgttaa tatcctcatc tgtttgcatc 2687761 gtgttgtttt tgagagcttc ccagctggct gattcttcag gtgtgagagc caggactgat 2687821 tggacgttgc catcttgctc ttggatgact tcacctttaa taatagtcaa agagcctaga 2687881 tccagattat catttagcgt agacttatat aaatttaaag agttgtaata cttcatcaag 2687941 ttagaaatat tatcagtttc aattctactt gaaaaaattg aacttagttt ttctttctga 2688001 tctatatagc ctctactctg caaagtttgt attatttcgt cttccaaatt gtatattaac 2688061 ctataagcat cattgacatt attatcaaaa tcaaccaact tttttgttaa gtcaccaatt 2688121 tgatcattta attttgaaac tgttttattt aactctttaa tttcttgatt taactcatca 2688181 atatgtttct ctagtttgtt gttatgttcc tcttgttttt cttgaagtgc attttctatt 2688241 tcctctaatt ttatcgctgc ttcgttcaga cgtttttttg cacctgaaat atcagtttca 2688301 ccgtcagctc cgtcaccctg tagcccatca ctttgatttg agccatcgtt ttcatctgcg 2688361 agttcaatca aagagaaatc tgttttagag gttcctgtat tctccgtgtt tgtatcttgt 2688421 tcaggaacgt tttttgaaga ttcttgatgt ttttgtcccg tttcaatgtt agtttgaaca 2688481 tcattttgtg atccattatc ttgagtaccc tcttctgatg agccagtatc ttcatttgtt 2688541 ggctgatcat cggatgttgg aatatcattc gacggttctt cagtattagg agaatcatcg 2688601 gttgatggtt cttcagcatc gggtgttgtt ggtttttctt gttcaggttc ttttaaccct 2688661 tcagagatat ctttaatttc agttgcaaca tttttgagct catcccgctg cttctctaaa 2688721 tccaatttta tatcttcaat atcttcctta tctgtgtcat ctttattatc agatgtgtct 2688781 tctccatctt ccttttcgtc gctttcctta ggtttaagta aactaaggcg gttcttcccg 2688841 atattctctt gcaattgatt taaattttga tatttaatag cttcatattg acttttatat 2688901 cgagatagaa atgcattaaa catgtcattc tcaatttttt tcatacccat ttcttgcaat 2688961 ggcacttgat tttgccttaa cttttcagca ttgttcaacg caaggtttgt cagtcctatt 2689021 tgtgtcttcg cttggccgat cccggttgcc aatccgctca tgcgttcgct gaactgattc 2689081 gccttttgct gtgcctggat ggcatccaga cctgtccgga tttgctgctg tgttgaatcc 2689141 tgggctgcca aaagcagctt tttctgattc tcttgatatt ctttgtacct ttcaactgta 2689201 tcaatgaatt ctttcagcgt gtttttggct tcctccgccg tagaagcttt ttcttttgtc 2689261 gtgccttgcg cttcattcat tgatttcttc agctcatcga ttaagtcttt ttgctgtttg 2689321 atttcacctg ctaaatcatt agagcttggt ttgtaaaagt tgtacatgac attctggaat 2689381 tcagattctt tattgacgat cttgtcaaat tctcctctga tgttgtccac tttttgcgaa 2689441 acaaaattcc agtataaggc cgacattttt ttgttcattg tcttttgggc atcctcaagc 2689501 tcacgctgaa ctttttcttt gttaaccgca ttcaggttat cttgaatgct gaattcgagc 2689561 gttgcctttt gaggatggtc tttgtcatag ctcaaaatgt tttttgagaa gtctgaggga 2689621 atgtagacaa tcgcatcgta tttctttgaa gcgagaccgg tctcggccgc gcttcggttt 2689681 acgaccgtcc acgaataatc aggacgttca cccagaacgg ccgctacttc cttgccgaac 2689741 tgggcggatt tgtcctcttc atcagacttt acctcatcac tcaatacgcc tgtgtcttca 2689801 ttcaccaccg cgatttgccg ggtagaattg actgcttttt tcgttgggtc gtctccgata 2689861 aatcggaaaa acaacaccgg cagcagcaaa atgatgatga cggcggatat taacttgatc 2689921 aagctttttc gttgttctgt catctagcac tctccctttc agcagaacat aaaggaattt 2689981 gaactttttg ctccttcccg ttttccacaa catatccgaa gcccggctga atctcaggct 2690041 cctgtctttg gtacgggaga ggaatgacat tttgctcaga ctttttcatc agcagaatcg 2690101 cgtggcggat ttgcttcatc tcagtcgtca aggagtcata gccttttgag aattcgctgt 2690161 ggtttccgcc cgggataaag ctgaacccaa gatgagcgta tgatttcatg aagttagcga 2690221 gacgatcttg tattctcgta tcaatcgtct gctggaatct cgttatcccg tcaatcatca 2690281 gcacgacttg tgagaatcgc agattttgtg cgtctccttg gcggacggct tctacataca 2690341 tggcttctct tgttttgaaa atgtcttctg ctgtttcaat ccactgctca atatcttctt 2690401 tcgtttccaa atatgaaaca tctgattcct tcgcataatg agataagccg cggtcaatcg 2690461 agtcaaacag gccgatcatt tcggtttcat catcaatcag atgttcaagc atgactttta 2690521 ggacgtttgt tttcccgcgc tgagtttggc ctaaaatcag gcagtgctta tgcttgccca 2690581 aatcaaaata gactgggctg actgtttctt catgaagccc gatcggtaca gataaaggct 2690641 tgcgttccag cttgaagcgg atagacaatt ctctcgtcga caagctctca ggcagcatcg 2690701 gaatcggtgc cggctgctcc attgaagcaa atcgcccttg aagtttctgt acgtctgatt 2690761 tcagctcgtt gaacatgccg atatcatcat cggcgtcaac aggcaggaac atttgcgcga 2690821 aataaagctc ttccttttga atgatgacgc gtcccggaat cggctcaaga ttgaatttcg 2690881 gacggccgta aatggaatat ccttctgatt gatccatgag ataatggaca atctttgttt 2690941 tcaagttatt taacaatgac tggcggacag cattcacccg cgttgctgtc agcataaagt 2691001 agatacccaa gctttgtccg tctctggaaa gctggacaaa ttccgattca agctcatgca 2691061 tctcatcctt gacaatgtca aagttgtcaa tggtgataaa aatgaatgga agctcttctt 2691121 cgctcagcgc attgtacatt ttgatgtggc tgatttcttt ttcccggaac aaacgtttac 2691181 ggcggtcaat ttcttctttg atgcgaatca tgaacttttc aattttcctt gactggtcca 2691241 tcaggaagta atccgcggta tgcgggagct tcgctaatgg cagcagcgtt ccgtttccga 2691301 aatcaaagat atagacatga agctcttcag gtgtgtatac gtccgcaaaa ctcatcagga 2691361 acgttgcggc tgcaatcgat tttccgtagc ccgaagagcc gaagatgccg atatttccat 2691421 cttccatcat cttataagca attggcgcct gtctttgcag atcaggttca tcgacatacg 2691481 caaagtggaa atggtctttt tcgtttgaag ggaaaagagt gcgcggaata cgttccgcaa 2691541 gcggcggcag ccaagggctt ggcagcttct cgattcccat ttcatcttgg atgcgttcaa 2691601 tttcgtcaac tacagcttcg atttcggttt gaacgtcttt tttcgcgtta tcttcggtat 2691661 caacctcaga aagcgggatc agacccgtat ctgtgacgat cgcgatttca tcctcggtac 2691721 cgtagacttc ctctaagtaa ggcgccccgc tccatgcaga ttggaacagc tcatacactt 2691781 cattgtttcc gacctgcaaa tagccgcggc ctgttacggt aatgtttgcg gcatcgctgt 2691841 ttttcaaaat ttctttactg tcggtggcat cctggacctt gagcgctact ttaaagcgcg 2691901 agttactcca gatctggtcg tcgatgatgc cgcctggctt ctgtgtcgcc aaaatcaaat 2691961 gaacgccgag gcttcgtccg atacgcgcgg cactgacaag ctccctgata aaatcaggct 2692021 cctcgctttt cagctcggca aactcatcag aaattaagaa caagtgaggc atcgccactt 2692081 ctgctttccc ttgcttgtat agctttgtat agtcattgat gtgattgact tgatactggt 2692141 caaacaggcg ctgccttttt tttagctcgc ttttaatgga agcaagcgca cgcatactga 2692201 agtttttgct tccttcaata tttgtgatcg tgccgaggag gtggggaatg ttacggaacg 2692261 gctgcgccat tcctccgcct ttatagtcaa ttagtaagaa agccgcttca tgcggatgaa 2692321 aatgcactgc aagtgacaag atgtaggtct ggagaaattc acttttccct gatcccgttg 2692381 tccccgcaag caagccgtgc ggaccgtgtg ctttttcgtg aaggttcaga tacacaatgt 2692441 catctttccc tttatagccg atcggcactg acagcgactt cgacgattca cttgtcagcc 2692501 atctttgctg aatgccgatt tcttttactt ccttcgcatg aaaaagctcc aggaacgata 2692561 ccgtttccgg aatggaattc gtaatgccga cctggtggtt cagcgtccgc agtgtgcgtg 2692621 aaaaccgttc gttatcctca cgctgatgat gatcgagacg gaacggaatt cttaccgctt 2692681 ttttcttttg tattaaaatg tcgccttcat gctcattaat gtagcggaca agagttgtaa 2692741 tgttttccga caagctttcc tttgtttctg cagcgacaat tgtcgagatg cccagatgct 2692801 catgctgccc ttctaaatat tcgagaatga catgctcaga gatcagctgc tgattcgtga 2692861 tgacaaatac aaaatgcggt ttgaactgca gtttttcttt gtcatcttcg agatcacgct 2692921 ctctgatcaa ttcgtaaagt gaagacagga gctgatctcg ggtttgctca ttataaataa 2692981 atccttttgc ataaatatgg ggcatttgaa attgcggaag ccacttcatc cactcccagt 2693041 ctttatactc ttcttcatga aaaataaata cgaaacgcaa atcgtgatag ctgttaaaga 2693101 acgacagctg tccgattagc tggtgaatct catttttcac aatttgtgat ttaccgacaa 2693161 gccccatcgg accttctgcc aaatcgaccg tcaccggcgc attacggata tctttataga 2693221 cgcgttgcat gtgctgcgat ttctccatga ggtcatcgat atcacgattc gccaagtctc 2693281 cgccactcat attgatttca tagcttgacg gaactgttcc cgtcccaagc cgcagctgga 2693341 gataatcctt gctttcaagt gatttttccc agatccggtc actgatttca cttgttaagt 2693401 atttcatttg ttcaaatgaa ggaaagtgaa attcaagaac ctgcttttgc ttttcagcaa 2693461 gtgcctgaag ctctttccgc ttattgtcta agtaaagctt atatacacgc tcccgttttt 2693521 cctcgcgttt tttccgctgg tttttatcac ggaaatattg cactgtcgag gtaatgagag 2693581 tcatcataaa catcgccaaa gaaacgagta taaatatgcc gcgcggctgg atgatggcaa 2693641 ctacgcccat cacgatcagc atcacaagcg gaggcaggat gacgagccac agccctctgt 2693701 tggtttgatc gctctcctga gagggaaaac tgaaagaaac gcggtcatcc ggcagatcgt 2693761 ataccatccg cggcgttctt ctgtactgcg gatatttttt ctgcatctct gtactcggtt 2693821 tgaccgtttc tgttaacgct gtttcaaact gggcataatg aacaatttct aaaaggtctt 2693881 gttccgtcac cctcatttgc gtgaagttcc agaatatttc atcccccggc ttgagcggcg 2693941 tattggcgtt gattttctct ccgttcaaga agatcgttcc gctttcaggg cggaccgacc 2694001 agctgccgcc tgcacggagc aaagaaaacg tgctttgttc tgcaaatgca aaatcttgcg 2694061 gattcagata aatatctgca ttcgtttttt ctgaggaaca tacaatttca tcccgatttc 2694121 ccgtaaaata aacggatttc tcaggttcac tgcccgtcaa tatcaagcgt atatcctgct 2694181 gatccgtttg gagagtaaat gatatatccg tctcaatcgt gccgagacaa tcatttccca 2694241 ggaaaacttc gtattggccg ccggattcct ttcttttaag agaaatcact ccgctattaa 2694301 atggaatggt gctgatcgta acagaatcct tcacatcagg ccctatggtc accggatgag 2694361 acgacgggag gttagacaga tttaattttt gaacgttatt ttggtaaaaa acccataata 2694421 gactcaaatg gcgaaccccc ttacggccga atggcagcat gcgatgacct gcgcttcatg 2694481 tctcacgtta tttgtcatct tttttctcat ctttcttttc tgtttctttt ttctcgtctt 2694541 ctttttcctt ctgttcttct tttttcgctt tttcctcggc tgcggctttt tcttctgccg 2694601 ctttctcttc tgcttgtttt tcttcgtctg tttgtgtctg ttcttcgctt gtatcgacta 2694661 acgatgtttc agaattagac tgtttatttt cttgacgttc tttttgggct ttttcaagct 2694721 cactatttac tgaatcaagt tctttttgta tgtcttcatc atttgtatcc tcagataaaa 2694781 gctgctgttt atatttagct agggcaaagt aaatataatc attgtattcc agcttacggc 2694841 cgatactgat cgcttctttg tattctcctc gaccataatc aatccaatat aagaaatgct 2694901 gagggtctga ttgaagggtg actaaattat tttctatatt tttggttttt gcactcccca 2694961 ggttttcgac ctcaacatag gacgtcgcca gctgatactg caccgattca ggcaggcttt 2695021 ccgcatcgta cttggacagt gtgctgatga cttcactgta ctgcttgttt aagaacgcac 2695081 ggttgctgtc cactatcgcc tggtgctttg gctgcgcgaa aaataaggcg tacatcgaat 2695141 aaataagtgc cggtacaagc aaaacaatga gccccaggcc gatatatcgc tggatgttcc 2695201 acttctttct cgggatatgt atgtatgttt ttgctttggc ttcgagctca tcaatatggg 2695261 tttgaatcag ctcgagcaaa tcatcatagg attcagcatc taatatcgcc tttgcctctg 2695321 cggagaacgt cagcgtttca ttgaatttca ggtagtcttc aaacgcaaaa gcgccgtcaa 2695381 ctgccaaagc cgctgccgct ttcagctcct gccatactct ttcctcatca cgctcgtaag 2695441 gaggaatgct ttcttttact ccataatgga gaaaataagg cgtaagccct ttatcgaata 2695501 caatgttttc aggagcgaca atcaaattca gcctcgacag attgtgctgc tgtacggctt 2695561 gaacaagctg ataggcaaac tgccatttac tttttttatc cttagctttc atgaagcgga 2695621 atgctttata ggaggaggga ggttggattg tgatgattac ttcatcatcc gtcacatcga 2695681 tttctttatg aaaaaatgga tttatatctt tgatcacgtt agcttcaaga ccgtcgagaa 2695741 gctttatttt ttcccgttga aaggtaaatg tatagccggc atctgttttc tcggcaacag 2695801 cttctaattg gttttctaaa tatgattttt gttcacctga cattcaacca gatcctttca 2695861 taatatttca agccggtctc cgtttgtaat gccgcaatca gacagcttgc attctccgga 2695921 aaacacctta tccttgttca ccactctgat ccagtgccct tcgcgcggag gcatagatac 2695981 gctttgggcc tgccaagcaa tatcaattac ttttttcacc gggtggtaat ctgacaatct 2696041 gagatcaaag acactgccgt tataatgttt caaatctatt gtaatatcaa tatacattta 2696101 ggatcaccct tacatagaaa gagcgccgtc ttcttttgaa tcaggcgctc cttccctttc 2696161 atactgttat ccgcggattt gatttgcgat gtcttggtca gtagactcaa gtgtatttgc 2696221 tgtttgatca agctgctgat tcacatcttg aagcaaatct gacattttga taaatgaagg 2696281 tttgagctgc tcgtattgat ctgcgaacgc ttcgcttgaa gcaccttccc acatgctttt 2696341 caaatcagag atcattcggt ttaaacgatc aacctgattt aatacttctt ggctttcaac 2696401 gccgtattgc ttcgccatcg ctcttagctc ttcgggtgtg acacgaatta atcctgccat 2696461 attcctcatt acctcctgtg ccatcagcct aaatatgggc taattcactt atttttagaa 2696521 cgtcattatt ataaaaacag tttttcggca tagtcaaaca aatatgtttt aattttacaa 2696581 aatgagtcca atggtttacc ccgaatcact caaaaatgac atatactgta aagtaaatag 2696641 gtttattttc ttaatcttct cttcattctc cgaataatcc aaaagaccca aataactctc 2696701 caactcccaa aaaaaacctt tcagaaaatt tgatgctaca gcaccatttc tgaaaggttc 2696761 agttttttct ttccttaatt agtcttgcct ccgatgactt tcttagaaga ttaataggat 2696821 aagctgtcgt attatatgag acatacactg tcctgcaaaa aggcgattac accgccaaat 2696881 gtatatagaa cgtttctctc atgaaattgt ttttttgctt ctgttctttg ttgttgattt 2696941 tcacaaacaa caacaatcat aataaaagga aggggatgag atgtcaaaga gaaatcaagc 2697001 acgaaaagta gggagattta tgaccatgcc gaatgatccg tttaaatata gttttgacag 2697061 acttgaagat gtggctgatc atatcagcga cgttctgcgg tgcccgatca ccatagagga 2697121 tgttaaccac aagctgcttg cctacagtac acacagcgac tgcacagacc ctgcccggac 2697181 gtctaccatt attggcagaa gggtaccgga gaaggtgatt aacaagctgt ggaaagacgg 2697241 gacaattcct gctctcttaa aaacggacca gccgatcaga gtcaagcaaa tcgatgaagt 2697301 cgggctgagc aatcgcgtcg ctatttcgat ttggaaaaac aagcaagtac ttggcttcat 2697361 atgggcgctt gagatccaaa aaacattgtc cgatgaagat ctgctgacat tgcaaatggc 2697421 agcaaaagca gtgaaaaaca agcttctcaa acttcaaatc agaaaaacga aaaatgaaga 2697481 acgcagccaa gaatttttct ggaaaatgct gaccggacac atccatcagg aggatgatat 2697541 ggcggatggg ttccataagc ttggaatggc cgctccttca gagttttccg ttatgatcat 2697601 ccgcataaat ggcgagctga ctgaaaaaat cgaacagcag ctgcaatatt tacaggaaac 2697661 gacccagcag gtttacgtgc tgctggcgac cgtagattcc aatgaactta ttatattaac 2697721 ctcacccaaa acagatcatc cttttcaaga tttaaaacag tttgctttaa gtacgcaaaa 2697781 acagctgaag gagcggtata aaatagaaga cgtttctatc gcttttggcg gaatatacaa 2697841 ctctatttct tttgtctccc gctcctatca ggaagcattg tccgtcttaa aaacgaagga 2697901 acggttcgct gaagagacca aacatctttt cagcttttct gagttaggca tttatcaata 2697961 cttagatgtc ttaaatgaaa aacggaaaca ggcgggccat tataattact cgctttccaa 2698021 actggaacaa tatgaccggg atcaccagtc aaatatggta gagacgctag agcgctttat 2698081 tgaagcggac agcaacgtga ataccgcttc caagctgtta aatatacacg ttaatacgtt 2698141 gaattaccga ctcaagcgga tcagccagat cgctgaaatt gatttgaaaa atgtgaatca 2698201 aaaattcacc atctatttag atatcaaact tcggcacatg gatttgtgaa atttcacaaa 2698261 tccatgtttt tttattttct taatcaaaca aagaattttc caaaatatca agctacacta 2698321 aaaatatcac atatacagga ggagacagat atgatcatag gggttcctaa agagataaaa 2698381 aacaatgaaa accgtgtcgc attaacaccc gggggcgttt ctcagctcat ttcaaacggc 2698441 caccgggtgc tggttgaaac aggcgcgggc cttggaagcg gatttgaaaa tgaagcctat 2698501 gagtcagcag gagcggaaat cattgctgat ccgaagcagg tctgggacgc cgaaatggtc 2698561 atgaaagtaa aagaaccgct gccggaagaa tatgtttatt ttcgcaaagg acttgtgctg 2698621 tttacgtacc ttcatttagc agctgagcct gagcttgcac aggccttgaa ggataaagga 2698681 gtaactgcca tcgcatatga aacggtcagt gaaggccgga cattgcctct tctgacgcca 2698741 atgtcagagg ttgcgggcag aatggcagcg caaatcggcg ctcaattctt agaaaagcct 2698801 aaaggcggaa aaggcattct gcttgccggg gtgcctggcg tttcccgcgg aaaagtaaca 2698861 attatcggag gaggcgttgt cgggacaaac gcggcgaaaa tggctgtcgg cctcggtgca 2698921 gatgtgacga tcattgactt aaacgcagac cgcttgcgcc agcttgatga catcttcggc 2698981 catcagatta aaacgttaat ttctaatccg gtcaatattg ctgatgctgt ggcggaagcg 2699041 gatctcctca tttgcgcggt attaattccg ggtgctaaag ctccgactct tgtcactgag 2699101 gaaatggtaa aacaaatgaa acccggttca gttattgttg atgtagcgat cgaccaaggc 2699161 ggcatcgtcg aaactgtcga ccatatcaca acacatgatc agccaacata tgaaaaacac 2699221 ggggttgtgc attatgctgt agcgaacatg ccaggcgcag tccctcgtac atcaacaatc 2699281 gccctgacta acgttactgt tccatacgcg ctgcaaatcg cgaacaaagg ggcagtaaaa 2699341 gcgctcgcag acaatacggc actgagagcg ggtttaaaca ccgcaaacgg acacgtgacc 2699401 tatgaagctg tagcaagaga tctaggctat gagtatgttc ctgccgagaa agctttacag 2699461 gatgaatcat ctgtggcggg tgcttaattc acaataagct tgcagaaaga tttctgcagg 2699521 cttttttatt ttttaaaagg aaaaaagaga ccatttcacg aattatgact atgaagttga 2699581 tcataaagga ggattcatat ggctgttcag caatatggcg tgttaaaagg catagtatta 2699641 gacatgaagc gggaaacaga tgatgacagt cctcatttcc aagtcaaaat gctcggtgaa 2699701 gagaatacgt attacaggtg cgccatcaat gtgatgtcca gttctgagga atctgaagta 2699761 ttgtatttgg ctgacgatca gtttgattcg ggctcaatta ccatccttcc gaacatgccg 2699821 tatggatata caaggatcaa tgaagcaaac cgtgaagtgg cactggatta tgtgcggggc 2699881 aatttgtttg acccgcggga aatgaagcct ttgcctcatg aaatcacggg acctgataat 2699941 gatttaaatg attttattga aacctatatg aagaaagcac aagatgagaa aacgccggtt 2700001 tatatattcg gttcaaaatt cggccctgaa caggctgcag ataaaatatt cggctttacc 2700061 ccgactaacg gaatgcacaa tatccatatg aatcaaggga atgcaatgga tacccgctgg 2700121 aaaaaagaca acggctcttg gcatgacggg ggtattctga ttcagtttgc agatcagtgg 2700181 gccgctgtgt ttttagcgtt tttatcccaa tcttggtgta ccgatgaaaa cggaaaccct 2700241 gtcagagatt gtgatcatac ccaaacgtct gcgtaagata gaaaaagaga ctgcggcaag 2700301 cagtctcttt ttgataagat tacacatttt caacagtctt taggctgttt ggcctcatat 2700361 cgctccaatg cgattggata tagtccaaac aagcttcacg ccctttttgc tcatgaacga 2700421 ctgtccagcc gctcggcaca tctataaaac ccggccatag ggaatattgg ccttcttcat 2700481 tgaccagcac caaatatgtg ccatccgcat tttcaaaagg atttgccatt ctatttctcc 2700541 tcccttattt attcaactct tccaatttga cagcgagaac cttgccgatt tgagccagag 2700601 gttcaggctg acataaatct ttatgacggc agtcgatgtc gatttgttca atctgtccgt 2700661 taatataagg cttccacgag tcaggttcaa tcgggtcaaa ccattcagga atgattgttg 2700721 atctgaaaaa caaaacattt ccgcggaagg ttttcggctt ataggaacct aaaatgccga 2700781 cagaatttac atacgtattc ttcaaattta aaatgaccgt ttcatccagg ctcgcaagcg 2700841 cactgccgtc acggcgaaga atctcaatcg ccgcttcaaa atctagcggt ttttccccta 2700901 agctgtctgg atcatacccg cctaacgcca gaagggcaat aagcgcttcc tcatcatccg 2700961 gtgcctcttt tataggaagg aagtggttcg gataggcgtc cagcatcacc aacagggata 2701021 cttcttctcc ttgattttgc agctgggtag ccatcgcttg aacgacattc ccgcccaggg 2701081 accagcccag cagatggtac gggccttttg gctggaccgt tcggatttgt ttaatgtaat 2701141 cggcagccat gtcatcaagt gttttcggaa gctcctcgcg ctgcccgatt ccccgtgcct 2701201 gcaagccgta gatcggataa tctgttccta tattggtcat caaaccggca taacaccagc 2701261 tgagcccccc tgccggatga acacagaata aaggaggctt gtctccgctt gttcggagcg 2701321 gcagcagaac gtcaagagcg ctttggcttg atcccatttc aagtctttca gcgagcccgg 2701381 ctacagtagg tgcttcgaac aagttgccga tgctgagttc aacgccgagc gcttcacgaa 2701441 tgcggctcat gagctgtaca gcaagcaagg aatgtccgcc taaatcaaag aaacggtcat 2701501 caatgccgac acgcggcaag tgaagcacct ccataaagag gtcacagaga atttcttcct 2701561 gcggcgttct cggtcctcgt cctgtcactg ccgctgcgaa atccggagcg ggcagcgctt 2701621 tacgatcaag ctttccattc ggtgtcagcg gcaattcttt catcgtcaca aaggcagcag 2701681 gcaccatgta atccggcagt ctctcagcag catatctgcg cagttccgcc gtatcaaatg 2701741 tttcttccga agggatgaca taagctgcta accgtttatc tcccggctga tcctcacgaa 2701801 cgatcactgc cgcatcttca agctgcggat gctgaacaag cgcggcttca atttctccca 2701861 attcaatccg gaatccccga attttcactt gatggtctgc acggccgaca tagtcgagag 2701921 aaccgtcagc gcggaggcgg gccacatccc cagtgcggta catccgggtg cctggaggac 2701981 cgaacggatc agctatgaag cgttcagatg ttaaaccagg ccggcctaga taacctcgtg 2702041 ctaaccccgc tcctgataca tacagctctc cggcaacacc cggcgggacc ggctgcaggc 2702101 gttcatccag cacgtataca ccaagatcgg gaatgccgca gccgatcaag ctgtttgccc 2702161 gtaaagctgc catgcttcgg tctaattcga tatagctcac atgcaccgtc gtttctgtaa 2702221 taccatacat attgataagc tgcggtctat tttcagggtg gcggttgtac caatcctcta 2702281 aacggctgag ttcaagcgct tctccgccaa aaatgacata gcgcagactg agtgcctgtc 2702341 cgagatccgg ctgttcccgt tccgcctgca taaactgata gaaagcagac ggtgtctggt 2702401 tcagaacagt caccccctct ttgacaagca ggcgcagaaa cgcttctggc gatctgctga 2702461 cgtggtgagg cacgattaca agacgtccgc catgcagcag aggaccccag atctcccaca 2702521 ccgaaaaatc aaacgcatag gaatggaaca tggtccagat atcacctgag ctgaaacgga 2702581 accagtgctc ggtcgctgca aataaacgtg ttacattttg gtgaggaatc atcacacctt 2702641 ttggaacacc tgttgagccg gatgtataaa tgacatatgc cgtattcaaa ggggaaagcg 2702701 gctgagtcct atccttattt tttggattac ctgcagggta cgtgtttagt ttctctgcca 2702761 gctcgggatc atccagcacg attttcggca cgttttcaac tggcggaatg tgatttgcag 2702821 ctttagtgtt cgtcatgata aacgcaggct gtgcatcttt tagcataaaa gcaattcgat 2702881 cagccggata atccggatca agagggagat aagctgcccc ggcctttagc accgccaata 2702941 ggccgacagc catttccaac gatcggggca gtgccaatgc cacaaattgc tccggcccga 2703001 caccttcact aatcatcatt cgggcaagcc ggtttgctct ttcattcagc tctgcatagc 2703061 tcagttcctg attttcatat acaacggcaa tggcatcagg acgtaaagca gcctgcttct 2703121 caaattgctc tggcaaacat gcgtgcggaa tcttttcaga tacactttgc caatcagtca 2703181 ccatgctgct gtgttcctct ggcgcaagaa tatccagatt tccgatttgc tcgtcaggat 2703241 cagactcggc agcctccaac aggcgcatca atcggtcagc aagagcctga gcagtttccc 2703301 gtttgaaaag atcagtgctg tattcaagca gtccttccat tccgtttggt gtcccgtcag 2703361 caaggcgatc ttcactaatt tccagcgtca aatcaaactt ggcagaaccg acactgttga 2703421 ttcgcaggct gctctccata tcaggaagat gcagttcagc gtccggtgtg ttttggaacg 2703481 caagcatgat ttggaataaa ggatgcgtcg cacgcgaacg agccggattg agcacctcta 2703541 caagtctctc aaacggcaga tcctgattgt cataggcggc cagattcact tcccgtactc 2703601 tgtctagaag ctcacgaaag cttgggtcac cggacgtatc agttctgagc accaatgtat 2703661 taatgaacag ccctacaaga tcgcccagcg catcatcatt ccgtcccgcg atcggactgc 2703721 cgatcggaat gtcggtgccc gccccgagcc ttgtcaataa agcggcgaga ccggattgaa 2703781 gcaccataaa caggctcacc ctatttgcgc gagccagctc ctgcaatcgc ttgtgaaact 2703841 cgggctcaat acgaaaatga atcgtatctc catcatgact cggctcagcc ggacgtgaat 2703901 aatcggttgg cagttcaagc tgatcaggca ggtttttcaa ggtttctttc cagaaagcaa 2703961 gctgtccggc aatcaagcta tttggatcat cctcgtttcc aagcagttct tgctgccaaa 2704021 gcgcatagtc tgcatactgc acagcaagag gcgcccattc gggagatcgt ccgtggcagc 2704081 gagccgcata agctgtccca aggtctctgg tcagcggtgt taaggaccag ccgtccccga 2704141 caatatgatg gacgagaaga agcagcacgt actcgtcagg accgatcaca aaaagctcgg 2704201 cacgaaaagc aggttcagct gcaagatcaa agctgtagcg tacagcttcg gcaagccgat 2704261 cagaaagctc cttctcagca atttcagtaa catgtaactc gggacaggct cgatcggcat 2704321 ctaaaatatg ctgataggat gtcccctgtg attcagggaa gatcgtccga agactttcat 2704381 gacggcagac gaggtcataa agtgccgctt tcagcaatcc ttgatccaac tcacctgaca 2704441 aacggacagc aaccggaata ttataagtag gactcggtcc ttccagacaa tgcaggaacc 2704501 atagccggcg ctgggcaaat gagagcggga tcttttcagg ccgctcagct ctctgcaaag 2704561 cgggacatgc actctgcgcc aaatcaagat gggcagcgag tccggctact gtcggttcgt 2704621 caaagagctt ggcgatacca agttcggctc ccattacctc gcgaatgcgg ctcatcagac 2704681 gggctgcaag aagagaatgg cccccaagct cgaagaaact gtcatcgata ccgacgcgtg 2704741 ccaaaccgag aacctctgca aacaagtcac acaatatctc ttcctgagga gtccgcgggg 2704801 cccgatcact gacagatgtg ctgaagtctg gtgccggcag tgctttccgg tcaagcttgc 2704861 cattaggtgt taacggcagc tcgtccatct ccacaaacgc cgacggtacc atataatcag 2704921 gaagactagc ccccatataa cgacgaagct ctgcagtatc aatagcagca tcagcgacta 2704981 cataagccgc caatcgtttg tctcccggct gatcttcccg tacgacaacc gcggcctgtt 2705041 caatgtgcgg gtgattggca agcacggcat caatttctcc aagttcaatt cggaatccgc 2705101 gaattttgat ttgatgatcc gcccgcccga tataatccaa agacccatcg gcgcgccagc 2705161 gggcctggtc tccggtccga tacatccgag ttcccggcgg tccgtatgga tctgcaacga 2705221 agcgctccgc cgttaaatca ggacgatgga aataacctct ggccaagccg gttcctgcaa 2705281 tataaagctc tccgacaacg cccggcggca ccggctgcaa tccattatca agcacataca 2705341 cctgcgtgtt ccaaatcggt ttcccaatcg gaggaacgcc cttcagccct tcttcaagaa 2705401 aagctgcggc agaccaaatc gttgtttcag tgggaccgta taagttcgtg actgaacaat 2705461 gaaggtcttg aagttcctgc aaaagaccgc tcggcagcgc ctcgcctcct acaagcactc 2705521 taagcccccg aagtttctca ggttcactcg ttaccaaagc gtgccacagt gtcggtgtcg 2705581 cctgcataat gttaatatcg aaattttcaa tcatttgagc taatgcctgc ggctcacgga 2705641 tcgtttcttt ctttgcgatc acgatttgcg ctccgctaat cagcggaaga tataactcca 2705701 atgctgaaat atcaaaagcg acagtcgtca cagccaacag cctgtcttct tctcctagag 2705761 aaaatgcctc ctgcatagac agcagaaaat tgcttaagct tttctgtgtc acaacgactc 2705821 ccttcggtct tcctgttgat cctgaggtat agatgatata cgcaggatgg tcaagcgaaa 2705881 ccgatacatc ctgattttcc ggcgaatagc gttttataat ctcctgtgta acagcctgat 2705941 caagcacaag ctcaggtaca gccaggtcat caggcagact ggctgctatt tcctcagtcg 2706001 ttatgatgca tgaaggtttc gcatcctcca gcatgtaaga aatgcggtcg gctggaaact 2706061 ccggatcaag ggggagatac gccgcaccag tcttgagcac accaagcatt gaagccacca 2706121 tctcagggga acgcggcagc gccaaagcga caaattgctc cggaccaatc cctttttcga 2706181 tcaacagacg cgcgaggcgg tttgcctctt cattgagctt tcgatagttg acttgaatgt 2706241 catcacacat gagagcgata cgttctggcg taagaactgc ctgcttttcg aacatgtcct 2706301 gaaggctgac cagcttctcg gattttgccg tctcattcca tttagaaatg actttttctt 2706361 tctcctctgg caacagaagc tccatttgcc caatcagcat gtcctctccg gcagaagccg 2706421 tttgcagcag ctgcaaaata cgctgctgat gaagcttaat atcagactca ctgtatacct 2706481 cgggattcgc atcaacatca attcgcagcc cgctgccgtc tgttctgtca tatacattga 2706541 ttgatagatc atcaacagga ccggctgaaa gattatgcgt tgtgccccgg acgccggcaa 2706601 agtcgagacc gtaatcaaac ggcataagat tgatttgagg gccaaataat ctatgatttt 2706661 ctcctatcaa tttcagatcg cgcctaagct cttcatggcg atacttatga tgtcgccgaa 2706721 tactgcggat ttcccgggaa atttgctgaa tcagttcaga aaagctcatc gaagagctta 2706781 ccgtcagccg gagcgggaga aggttcatca ccatagccgg tacattcagt gacgcggacc 2706841 ctatccgacc catcatgggc aggccgagca caacatcctc agagccggtc atacggtgca 2706901 cataaacagc tgacaccgca atcatgactt catgccagct tcctgagaaa tagcgcgccg 2706961 cttcttttaa cgcgtttaca tcagacggag gcagatatgc cgtatgacga agaaaactgt 2707021 tagatgttct tggcgcccga tcagccaagc tcacaacttc aggtgcatct gcaaaacggt 2707081 ccagccagaa ttgacgatcc ttctcatact gctctgatcc gcgataatct gtatcctcct 2707141 ccaaaatggc ctggagagac ccaaaggaac ggcttttagc tgtttgtcct tttataaggg 2707201 cagtatatgt acttgccaca cgctgggcta tcagggaaaa accgaagccg tcgatcgcta 2707261 tatggtgaat gcgctgatac caaaagaaac gatcaggccc ggcaataaac agagcttcat 2707321 tgaacaaagg ggcataccct aaatcaaccg gctttgctaa atcagctttc atccagttta 2707381 atgctgtttt ttccggatca ggctcagagc tgacgtcaat gacgtgcagc tgtacatccg 2707441 gagacgggtt tatcatctgc caaggcccgt ccatattttc accgaagcgg acatgcagcg 2707501 attccgcttc cttgatcacg tgccgcaaag cttcttcaaa aagagcaata ttgactggtc 2707561 cattgatttc tatatattcc gctgtattgt agattggatt gtccggatca agctgctgag 2707621 caaaccatat gccagtttgc gccccggtca aagaatattg aagatctttt gtatcaggca 2707681 tccgtttgtt taccctcctt ttataaataa tccgcgtttg gcagcacttg ctggctgcga 2707741 gttgtgagca atttctgcca ttcttcgatc gttgggcgtt cagccaattc cacgaaagtc 2707801 acctctgccc cttcacggcg ccattgttcc accaatgtca tgatccttac cgaatcaaga 2707861 ccacgatcga gcaaatcctc ttgatctgtg atgtcttccg gtgtttcttg tagaagctca 2707921 gcaatttgtt tacggatatt ctcacatgta aacacgttct ttttgccagt gtttgctgac 2707981 gttttttgaa cgtctgccgg cgcattctgc agctgatcaa gaagactgtc agtcatcacg 2708041 gtaaacgcac agcgtccagc cgcatattcc agcgccattt gatgtttttc taatgaaaaa 2708101 tcagcaactg catctcccac aaaaaaggct ttaatatcct ccataaatgc ttcacatgct 2708161 gtaacaagac agccgatatg ggcgtaaatt cctgtaatga tcagctgatc gcgtccctct 2708221 ttgcgcatca tttcaagcag attcgttctc ttaaacgcgc tgtatctcca ttttgtcagc 2708281 acaagatcat catcctctgg tgccagctcg gttataattt tctcctcata aggaccgctg 2708341 tttaatcccg ggccccaaaa gtctgtcagc agcgcacggt catccggatt ttggcttccc 2708401 ggctgtgcgg tatagacaac aggaatccca agctgaacac attgattctt cagctttcgt 2708461 atattcgctg aaagctctgt taccggagac gctcccgctg tgaaagcatc aacaaaatag 2708521 ttttgcatat cgtgtattaa caagacagcc cgattcggat caggcaccca tgatactttg 2708581 ttttgcggca tatcagatgc tgtcggcatt tgatacggct gaatggcagg tatagccata 2708641 tgaacacttc ctctcaaatt gttgttttat tttttaaatc ctgcaagaag cttctcggaa 2708701 atggcttcac ggagcgcttt tttgctgact tttcctactc ctgtctgcgg gaaggattcg 2708761 acaaattcaa ctcgatcagg gattttatat gccgccagtc cgcgctctct caaaaatgct 2708821 ttaagctctg cggcttttgg ggcttcatcc cggggaataa tgaacacaca agatctttcg 2708881 ccaagaaatt gatcaggcat ggagaccatt gccgcatcat ggacagccgg atgcgccagc 2708941 agatgatttt ctacctcttc agccgcaacc ttttctcctc cacggttaat ttgatccttc 2709001 gcccggcctt caacgacaat atagccgtct cgtgtcagcc tgacgatatc acccgtacgg 2709061 taaaaaccgt cctcagtaaa tgaagcggcg ttatgctctt ctgccttata gtaacctcga 2709121 attgtatacg gcccccgcgt cagcagatgg cctgtttcac caggttttac gtcgcgatca 2709181 tgatcatccc aaacacgcat ttcatcatat ggagacatcg gttttccttg ggtgttgaca 2709241 atgatctcct caggatcatc caatctcgta taattgacga gaccctctgc cattccgaac 2709301 acctgctgca gcgtgcagcc gaaaacagct tttaccctgc gcgcggcttc agcactaaac 2709361 ttggcaccgc cgacctgcag cacttgaagg ctggataaat catcacggcg tgaggatgcc 2709421 gcatccatcc ataccatcgc aagaggcgga acaagagcgg ttatcgtgac cttttcccgt 2709481 tcaattaaag gaaatgcgtc atctggactt ggagaaggag ataataccac tcttcctcca 2709541 gcgtataata cgccgagaac gccgggtgag ctcagcggat aattgtgtgc catcggcagc 2709601 gcggccaagt acaccgtgct gtggtcgagc cagcagacct ccacactccg cttcaggctg 2709661 tatatgtagt catcgtgggt cctcggaatc agtttcgata gcccggtgct cccgccagaa 2709721 agctggagga acgccacatc cgatgatttg acttcaggca gttttacagg ttctgcatgc 2709781 aaatcctcca gcggtaaaaa ttcctctgcc tcacctgcga caatgatgtt tttcaaagtc 2709841 ggcagcttgc tttgaacctg tctggcaagc gaacggtagt caaaaccgga ataagcgtcg 2709901 ggaatgatat atgcagccgc ttcagcaaac tcgcaaaaat atgtaatttc actgcttcga 2709961 tgagaaggca gtgcgaagac tggaagcgcc cccagacgga aaagcgcgaa aatgacttca 2710021 aaaaactctt tgatatttgg caactgcacc acaacacgat ccatctgttg aatgccgagc 2710081 ttttgaaatc cggcagccag gcgatcagcc cttgtgtcaa gctctcgata gctccaatgg 2710141 gtgtttccgc atgtaatggc aatgcgatca ccatatttgg ctgcccggtc ccttaacaaa 2710201 tctccaaacg tctcaccggc ccagcagccg ttctttcgat aggtctcagc taactcatca 2710261 ggccaaggcg taaatccttt cagcatgttg tatccctcca gcaattcatt ctgttcatat 2710321 gtgatccacg cccattgccc gcagcattgt ccgaaacttt gcggacgtct cctgaagctc 2710381 gtcctcaggc tttgaaccgg ccacaacacc agctccagca tacaggcgga gtgagcgttc 2710441 ttctgcttct gcacaacgga tggtcacgat ccattctccg tcaccggcat cgtcacacca 2710501 tccgaccatg ccggtaaaga aaccgcggtc aaatggttca atgctgagaa tcgcttctct 2710561 tgcaagatca gtcggtgttc cgcagacggc tggcgtcggg tggagcgccg ccgccaattc 2710621 aagtgcggtt acagacgggt cggaaagctc tcccttaatc acgctggaca ggtgccacat 2710681 cgtttccgtt ttgatcagtg aaggcttctc cggaacctcc agcgtccggc agaaaggtct 2710741 cagcgctgcc gcaaccgcgt cagcgacaac cgcgtgctca tgaagatcct ttgcggaaga 2710801 aagcaattca gctgcccggc gctggtcttc aacaggatca ttactgcgcg gtcttgagcc 2710861 ggctaatggg ttggaaacga cctgtgttcc catccttgaa acgagaagct ccggacttgc 2710921 tccgagcaat gttctgcggg gagacgtttc ctcctgactg gacacgtctg cggcaaacgt 2710981 gtagccatgc gagttatgct gagccagatg gcgaagcaat tcatccgtct gaatcggttc 2711041 aggcgatgtc aaatgcagcg atctggacag gacgattttg ctgagtgttc catcggcaat 2711101 gcgtgccagc ccttgttcaa caccattttt ataatcctca ggttcaggaa caggctttat 2711161 gtggtatgta tgcccagcct gctgttcctt ttcctcatga tcaaattgaa gcggtcctga 2711221 ccagcgcact tcttcaggta caacgagccg cgctgctttt acttgatcaa aaggaacggc 2711281 cccgacaaca agcggccggc tttgccctga ttgttttgcc tgacgtaacg cctctgcaat 2711341 tcggccagaa agggtttcca tttggttttg cccgtctgcc tccggtacaa tttcacatat 2711401 gcctttcgct aacagtacac gatgaggaga cgctaagaaa aaggcgcccg gctgatattc 2711461 atgaagcaaa tgctccgctt ttgtttctgt tataacgttt tgatccaaca ttctcatgaa 2711521 cctcctttaa attcagttac acgcctaagg tcgcgccgcc atctacgcat aaattatgca 2711581 tcgtaatatg ccctgcctgg ccagaaacca aaaagagcac cgcatccgca atatccgaag 2711641 gcttggctag ttttttgagc gggatccctg ttttaaatgt ctcaagtgat ccttttatga 2711701 cttgctccgc tccattctcg tcggcccata atgaccactg catgtctgtt tccgttgatc 2711761 cgggagatac aatgttgcag cgaatattgt attctgcaag ctcaaggcca aggcatttcg 2711821 taaacatcac agccgcagcc tttgaagacg catatgccgc catagatgtt cttggtacac 2711881 cggcagcatt cgatccgact gttacaatcg aacccgatct tcggtccatc atatatttgc 2711941 tgactgaacg cgaggcgtta aatacgccag tcgaattcac tgagaacgtc gcctcccatt 2712001 cctcatcgct aagcgaatgg atcagtcccg ggcgaaggac acccgctaca ttcactaaaa 2712061 tatcaatcgg ccccatttca cgttcgatgc gcgccgtgat ctcgtcaatc gccgcgctgt 2712121 ctctcacatc cgcaggaaaa gcttctgcat ggcggccttc tgctttgagg ctgctcacaa 2712181 ccttttccag cttttcagga ttataatcaa ctgccgcaat atgtgcgcct tgactggcaa 2712241 gcgtccgcgc aacagcttcg cctattcctt gggcagcccc tgttataaaa gcaatttttc 2712301 cctctatacc ctttgcattc atatcatcaa ttcctttctt cgctctaaat gccaaacaga 2712361 catccagcga aaaagactgc tgcgccttga aaaacgcaat ctattgataa tgattatcat 2712421 tatcaattat aaaaataatc atatccaaat gtcatgtgac agtcaaatat aatttcagtg 2712481 acaaatattt ttttaaaggc aaggctgagt atgtctcagc ccattgatag atgcggtccg 2712541 tcagggtgaa gcgcaaaacg cagcgccctg ctgaccaaaa caggaagaac tgaaatatgt 2712601 ccttctcctg aaaactcgca aaattctgcc cgtatacctt gttcagataa aacggccagc 2712661 cgctcataaa gctcccttgc attatcattc atccggcttt tatgatgctg ctctaattct 2712721 cctgcggcaa gcaggatatt gataggctga ttgtttttct tggtgagaga gacgaaatgg 2712781 tccgttttct tgagaataaa cggtttattc caatgaatgg acggacttcc cgcgatatac 2712841 gtttgaaacg catcgggctt tgttagcagc acctgcagca cgaaaagccc tccgagcgaa 2712901 tggccaaaga ttgtttgtct ttttttatca atctggtaat ctcgttctat ctccggtttt 2712961 aaatcctctt caataaatct gaaaaagccc tccgctccgc catgctccgg ccattctctg 2713021 ccgtcgggcc tttccggcag cttcgattgg gctgttggca ttgtaaaatc ccggtggcgt 2713081 gctgaggaga acggctccgc tgtctcatag ccaatgccga cgatcactgc agggatcacc 2713141 ccggtttttt cgggtcggcg tccctgtatt cgaacggctt ccgtcatcgt tccgaagaca 2713201 gaattggcat ccagcagata aatcacagga taaccagcgg gtggcggcgg cgtactaggt 2713261 ttcgagataa aaatgtgata ggtacggttt tcattgcgtg aagacatcat acgcacttcc 2713321 gtaccaggaa tcgtaaatgc gtttgatgtc ccgccatttg tccggtctgt tgtttgttct 2713381 ttcatgcagt acgacattcc tctccttaaa ctaaaccgca atgtatgata atgattttca 2713441 ctatcaacta gacacctcaa ataataggtt ttcttccaaa gaaagtcaac tttttcccga 2713501 ataaaaaagg caccttgatc aaataaggta cctgcagact atcaatatgg aagtaaaaac 2713561 ctaataaaga tgcgtattgt cctatttgaa atagaacctt aatcccatgt aaacctttga 2713621 ttttgccaag ggtcgcctct catgtgatag ccattccgct cccaaaagcc agggtgattt 2713681 tctttcgtaa attggatgcc gcgcagccac ttggcgcttt tccaaaaata cagatgcgga 2713741 aatacacccc gcagcggaaa gccgtgttca ggggttaaag gttcgccatt atgcgcataa 2713801 gccagaaggg aagtttccgc taagaaatca tcaagcggca gattggtcgt ccagccctct 2713861 tcagcatgta aaatgacgta gcccgcttct tcttttacac ccgctttttc cgctatatca 2713921 caagcccgca cgccttgcca cacattatca agccttgacc atcccgtgac gcaatgaatg 2713981 tcgtttttcg attcataccg tggaaaggct ttgacatctt caaagcttag cagcatcgga 2714041 tggtcaacca aaccgtatac ttgaagattc catttcgtca tatcttcgta atatgggaca 2714101 tctccggtat gaagcacagg aaatgaagtg gtgacgtttt gatttggcgg cactcttcca 2714161 gattgatcgg actgtcttgt ttttccgaaa tacatatggg cctccttttt gttaacctaa 2714221 tttaaaatca tgttgacaat ctttttgttc tttattactc tatgattgtg tatgtcaacc 2714281 taagggggaa caacgatgaa acaacgtaaa cttcgtgcgg gagatatggc gctgattggc 2714341 atgttcgccg cacttatggc tgtcggggcc aacattacat cagtagcacc ctttttacaa 2714401 gtagccggca ttccgctttc gatgcagccg tttttctgtc tcttggcagc tttgcttctt 2714461 ggcagcaaac gggcagcgat tgccatgatt gtatatgcac ttgtgggatt ggccggagcg 2714521 cctgtgtttg ctcaattttc agcaggcttc gcaccgtttg cagggaaaag cggcgggttt 2714581 attatctcat acattccggc agcatttgca gcgggatggt ttttagaacg aaacattcag 2714641 ccaagtaaaa ttcgatttct cattgcttca cttatcggaa cggcgatcat gtatctcatc 2714701 ggcactacct atatgtatct tgcactgaag ctgtggattc atacgccagt gagctacggc 2714761 acggcttggg gctttatgat ttggtttatg gtaaaagata cagcgctggc tgtgatactg 2714821 tcgtttatcg caccagcaat ctaccgctct attcataaag caaccggctt taacagaaat 2714881 cacatatcat ctacgtaaaa accgttctat tggacggttt ttttatcata acgagaaaag 2714941 gctccccagt aaaggggagc ctttttccta taaaacaagc gctgcaatcc agccaaagat 2715001 gacaagcgga atattataaa atataaatgt cggcacacaa gtatcccaaa tgtggtgatg 2715061 ctggccgtcc gcactcaaac ctgaagtcgg cccaagcgta ctgtcactgg caggtgaacc 2715121 ggcatcgcca agcgcagcag cagccccgat aatcgcaatc gttgccatcg ggctgaatcc 2715181 aagctgcatg catagaggca cgaaaatggt tgtgataaca ggaatggtcg caaaagaaga 2715241 tccgatcccc attgtaatta ataagccgac aatgagcatc agcaatgcgc ccaaggactg 2715301 actgtgtccg ataaaaccag ctgacgtttt gaccagtgac tcgacatctc cggttttcgt 2715361 caatacgttt gaaaatccgg ctgcaacaag catgacaaag ccgataaagg ccattaaaac 2715421 cattccatca gtaatcagtg agtccgcttc atcacgcttc atcacaccgc tgacaaacag 2715481 aacaatcaga ccagcgagcg cccccataat cattccttct actcccaaag tctgagataa 2715541 gtaaagctgg acgccgagtg acacaacaat ggctagaacc gcgataccaa tactttttct 2715601 cgtatatggc gatgcttctg cacctgaaat gtcttttgtt tcatattgtt tcggtttacg 2715661 gtatacgatc actgataaaa taaggccgac aaccatacct gcaactggaa taatcagtgc 2715721 gtacggaata tcagcaagcg gaacgtttaa cccggcatcc gccatattgt ccttcagcat 2715781 gccttggaag atttggccga aaccgaccgg aagcaaaata taaggagccg ttaagccaaa 2715841 tgtaattaca cacgcgatca gacggcggtc catttcaagt tcattaaaga ttttcaaaag 2715901 cggcggaatc agcaccggga taaacgcgat gtgaaccgga acgacgtttt gcgaaaaaca 2715961 agatacaatt aaaataatca gcacaatcag caccttagac agtgcttttt ttcgagaatc 2716021 ttctttattt ccgattaatt taacggaggc ttccaccatt gcgtccggaa gacccgtttt 2716081 cgtcaaagcg gcggcaaacg cgccaagcat ggcatagcta actgcaacgg tggcatttcc 2716141 gccgagaccg tctgtgaaag ctttaaccgt ttcgccaaga ccgagcccgc ctgttaaccc 2716201 gccggccaag gcgcctataa ttaatgcgat aacaatattg acacgcagca ggcttaatac 2716261 aagcataagc aggactgcga tgacgactgc attcatgatg atacccctcc aaaaatcctt 2716321 tagtttgcta atgtagtaga taaataaagt acgaacgtat cgtatcataa ccgatccact 2716381 ttagtcaact aaagatttcg gaagaaaaaa tccctgccgc atcatacagc agggattttt 2716441 cattactcgt ttttatcttc ttccaatgta aatcgctccg caagtgtagc cagtgttctt 2716501 gccataacgc cagtagcccc ggccggtccg aagcaggttg ctttattggc agtcgctgtg 2716561 cctgcaatat caaggtgaac ccaaggtgtt gactcagcga attcaccaag aaacgttcct 2716621 gccataatcg catgtccctc gcgtcccggt gaattgctga gatccgccat ttggctgctt 2716681 ttcacgcgtt ttttatcctt ctctgttatc ggcagctgcc agatcgcctc gccgcactct 2716741 tgtgcagcat cagctacctg ctggtaaaag ctttgatcat ttgtcattgc accggttgtt 2716801 tctgttccta atgccacaac gacgccgccg gtaagcgtag ctacatcgac aagaactgat 2716861 gcgccatgct gtttcgcgta tgtaatgcca tctgcaagca ctagccttcc ttcagcatcc 2716921 gtattaagga tttctattgt ttttccgctt aaagatacga tcacgtcatc cggcttcatg 2716981 gccccgccgg agatcatatt atcggttgat ggaataacgc acagcacgtt ttgttcagga 2717041 cgaagctctc cgatcgtttc catagccccg agaaccgcag ctgctcctcc catatctgat 2717101 ttcatgccaa caattccaga tttcgtttta atggagtagc cgcctgtgtc aaaggtaatt 2717161 cctttcccga ctagtccgac gacgtcttcc cattcctttt tgccctgata tttcaacaca 2717221 atcattttcg gcggttcggt ggagccttgg tttaccgcaa gtattccgcc cataccgagc 2717281 tcttccatct ctgatttctc caatatctca cactcaaaat catatttcgc cgcaagctct 2717341 tcagcatacg aagcgaggtc agtcgctgtc agcatgtttc ccggcatatt cacaagcgtt 2717401 ctagccgaat ttgtcccttg tccgtatgcc tggccgacgc gaagccctgc ctgcacttcc 2717461 tgtgtatctt catctgttac aacatacacg gcttcaattt gtttgtcagg ctcatttgat 2717521 ttatgcttat aatcctgcac ctcataggaa gcaagcaggc agctctcagc taaagcatga 2717581 gcggcatcgg ctggaggcac gtcttccgaa ataaacgtat caagcagaac agcagtttct 2717641 tgttttcgat ctttatgaat ggcttgaaaa acatgagcaa aacgttcctt cgcctgttca 2717701 aacgaataat ttgcttctct ccccaggcca acgaaataaa tccgtttcat acccgcagaa 2717761 gatggaggga atacttttga tacttgattc ggtttcgcag agacatcacc ctcttttaaa 2717821 agctgtgtca gatggccttc gagcatttca tcaatttcca acgcttttcc tgtcagctgg 2717881 cttttttgaa aaagcccgac aacaagggtt tctgtatgct ctgattgttg aaccgcataa 2717941 aacatgaggc ttacactcct aacgtaatgg gtatttgtaa tgaacaatgg tataatagga 2718001 aaaacattct ttccactata cttattttaa caaacaacag tctaagactt gcttttttct 2718061 tttgaaacac gaaggatttt tcaaatagaa aggatgtcgc cgatggaact tttaacgaat 2718121 tttcctttat tatcaagcct ggccgcaatt atttttgctc aggtcatcaa agtgcccata 2718181 cagtttatcg tgtccagaaa actggactgg tcgctggtca caagcacagg cggcatgcct 2718241 agctctcact ccgcagcggt cactgcgctt tctacaggcg tagccttgga gcatggatta 2718301 gactcctcac tctttgcggt ttccgccatt ttcgccgtca taaccatgtt tgacgcaact 2718361 ggcgtcagac gtcacgccgg tgagcaggca acagtcatta ataagcttgt tattgatttt 2718421 aaccgtttcg taaatgaagc gaaggacttc cctaaggctg cagagaaaga aaagcaaaaa 2718481 aagctgaaag agcttctcgg acatcagccg atcgaagtct ttttcggagg attaacaggt 2718541 attttactga cattggtact cgcttacttt ttcatgtaaa aaaaacgctc ctgctttcgc 2718601 tggagcgttt tattctttca ccgttttata ttgatttctg aacacttgca aagattttgt 2718661 ttcattgagc ttctcaagct catcctcggt aatctttccc gttccctttt taatcacata 2718721 tacatcaagg gtttttttgc cccattcatt gtatacatct ttgactgtct caaagtacag 2718781 atcaaggcgg tttcccttaa tagctgatcc tgtgtcggcc acaactccga gaccgtagtt 2718841 cggaatgaat aaaattgttc cgatcgggaa aacggacggg tcagcagcaa ccgtggaata 2718901 taaatcccgt ttcactttca cacctgaata tgtaagcccg tataatggat caccgggatt 2718961 tttgcccgtc gactcagctc ctgctgtgta gcctgttgct gttactcttt ggactggata 2719021 ttcatcccaa tcaaatgcct cttctaacgg ttttgtttta tcctcagccg cggacgtggt 2719081 ttgtgtttgt ttctgctgca atgcttttaa tctcagtcct gcatgcttca agtgcttttc 2719141 ctgatgttcc tgcacccatt ttgacaagtc cttcgcttca attcctgaca ctgataaaaa 2719201 tgtcgtgcca aatgcaagca gaaataaaca ggtcatcagc aaacgtctga tcatattcaa 2719261 catcattcac ctctcctccg aatcattgtt cccaagtgga gagagcatta ttcaaaatgg 2719321 tgaatgagct gaacgcataa aaaaagcttt ctttagaaga aagcggcatt taaaacattt 2719381 gatatcctct ttttctaagc atgttgatcg ctataccgga cacgatggcg ccggccaaac 2719441 cgctgactaa aatcagcaca tcagcagccg ctaatgataa gacacgatga aacaggctgg 2719501 caaaggattc tcccggcgac tggacatagc tgatcagctt ttctttgctg ataatgaaaa 2719561 ggcatacaat tggataaatc acagccataa tccaagacat tctcagcagc atgtttaata 2719621 agaaaccgat tccaaaaaac aagacaaaaa acaaaacaat tgagatgatt acgactggca 2719681 gactaatcaa cctattccac ccccctgcgt tgtttttagt gtaacgcggg ggctgaaata 2719741 aagtcaacgg ctggaaaaag aatgactgtc ttttcctgtc ccctggcaag acggacaagt 2719801 ctctgaaccg ccgagaatca attgaaaata tcctttccct gaacaaaatg ggcatgcatg 2719861 tgaagcggtt gtcgttgcag ttttcatcta atcatcaccc tttttcttaa ttttctgata 2719921 atataccata tcaagctgtc aacaataaag tcagatcatg tgacaaatct tttgatgtaa 2719981 gcggaaacat acttgttttc ctctcgttct ctttttattt tggcgttttt taataaagaa 2720041 aacccgcttc cgcgggtttt tagaaaaact tgaacttgcc ttttttcaat gtcagtccga 2720101 gtccgccaat cataaacagt gagcggttat caatgacttt tttcataaac gaagcgggcg 2720161 tgcctttcag ctttctgcca taaacaaccc caaccgcgtt atgctcgcca agagaagcca 2720221 ctgttccctt aatgtccggc ttgaattcct caagctctcc gcctttaata agcctgccaa 2720281 ggtttttagc gaccgttatg ccctgctgca ttgcaatttg cgcagtcggc ggatacgggc 2720341 gctctgtatc ttcattcata aacagcgagc tgtcgccgag aataaagaca ttgtcatgtc 2720401 ccggggcgcg gagatcaggg ttgactttga ctcggccgcg catattctca aaaccggctt 2720461 cctccacaat cggatggccg cggacacctg ccgcccatac aacggtttgc gatttgatct 2720521 gctctggttc ttcatctttt ttgccgactc tgactccttc tggtgtacat tcttgtacag 2720581 ccgttccgat cttgaactca actccgtttt cctcaagata atgtacggcg taatcaacaa 2720641 gttccggatc aaagcccggc aaaacggtcg gcgctgcttc cacacaaatg atgcggacaa 2720701 ggcttctgtc aacgtcatat tccttacaga gctccggcac gcgagcagcc agttcgccaa 2720761 gaaattcaat tcccgtaaat ccggcaccgc caacaacgat cgttaacctg tccggccgtt 2720821 tttccgcttc cgtattgtaa gtcgcaaact gcagctcaat atgttcccgc agcaggcgcg 2720881 acgtgttgat gttggcaatc ggaaacgcat attcttttaa gcctttaatg ccgaacgttt 2720941 caggcacggc gccgagcccg atgactaaat aatcgtactg caattctcca ttcgcaagca 2721001 caactttttt ctcatcaatt ttgattgcct ttacggtatc ctgtacaaaa ttcacccgtg 2721061 actggttgat tacatctttt atctgataac ggcagcggtc atgatggagc gtacccgcgc 2721121 tcgcttcatg catccatgtc gtttcataat gataattgtg tttatttaca agcgtaatgt 2721181 cagcatcatt cggcccgaca tacttcgtca gccttgtcac cgtcatcaat ccgccatatc 2721241 ctgcacctaa aatcacgatt ttgggcttat tcaatgccat cacatccacc ttctcttttt 2721301 ttgcttttgt tagacccata ataaaatcat catttgtgtt agcttcagct tattggcggg 2721361 attttatgaa atatattgaa aagttttttg tgaagtcctt acccgtagca ctattatcat 2721421 gtttatccgg ctggcccaag aaacattcag aaaaagatca tttcatttgg ttattatcgt 2721481 agcggcctgc ggaaatattt tcaagaacgg atgggcacgt tagatcctta cgattttttc 2721541 tgctgactcg tcaatttgaa cggcaatatg gtataattaa taacaatttt catttaggag 2721601 gcaattttcg tatgcgagag gatacaaagg tttatgatat tacaattata ggcgggggac 2721661 cggtcggctt attcaccgct ttttacggcg ggatgagaca ggcaagcgtc aaaattatcg 2721721 aaagcctgcc tcagctcggc ggacagctta gcgccctata ccctgagaag tatatatatg 2721781 atgtagcggg attcccgaaa atccgcgcgc aagagcttat caataaccta aaagagcaaa 2721841 tggcgaaatt cgaccaaacc atttgtctgg agcaagcggt tgaatctgtt gagaaacaag 2721901 cggacggcgt gtttaagctt gtaacaaatg aagaaaccca ctactctaaa acggtcatca 2721961 taactgcagg aaacggcgca ttcaaaccga gaaagctgga acttgaaaat gccgagcagt 2722021 atgaaggcaa aaacctccat tacttcgttg atgatctgca aaaattcgcc ggcagacgcg 2722081 ttgcgatcct tggcggtgga gattccgcgg ttgactgggc gcttatgctt gagccaatcg 2722141 caaaagaagt atcgatcatt caccgccgcg acaagttccg agcgcacgag cacagtgtgg 2722201 aaaaccttca tgcgtcgaag gttaatgtcc tgacaccatt cgtccctgcg gagctgatcg 2722261 gcgaagacaa aatcgaacag ctagtgcttg aagaagtgaa aggcgaccgc aaagagattt 2722321 tagaaattga tgacttaatc gtcaactacg gtttcgtttc atctcttgga ccgatcaaaa 2722381 actggggcct ggacatcgag aaaaattcca ttgtcgtgaa atcaacaatg gaaacaaata 2722441 tcgaaggctt ctttgcagca ggtgacattt gtacatacga aggaaaagtc aacctgattg 2722501 ccagcggctt cggcgaggca ccgacagcag tgaacaacgc caaggcttac atggacccga 2722561 aagcccgcgt acagcctctt cactcaacaa gtctttttga aaataaataa taaaaaaagg 2722621 agcttgtgtc tgcgacacag ctcctttttt atttgaagat atttatataa ttcaatgcag 2722681 ttcctacaac cagcgcaatc acaagggctg cgactaccca gatcattgcc ataataatgc 2722741 ggtcctgaat cttttgggac ttcggtgttt tttcttcgtt ttgggccatc ttattcgctc 2722801 ctttcccatg tccatgccat aaagaaagcc tggtgctgaa cgaccaagct ttgctgaacg 2722861 tatatcattc gcgttttgat ccgctctcta agaccattcg ttaaaactat gatacctaaa 2722921 ctcaccctgc atgacaagct tcggcacttg caccacacct gccagcaaat cataatgttt 2722981 gacatcctaa ataaaacaga gtacattata taaggcgaac atttcatata ttatactttt 2723041 aaatattcgt ttttaggagt gaaaaccatg gaaaacgtat ttgattacga agatattcag 2723101 ctaattcctg caaaatgcat tgtgaatagc cgttcagaat gtgatacatc cgtacgttta 2723161 ggcggacata catttaaatt gcccgtcgtc cctgccaata tgcagacgat tatagatgaa 2723221 aaactagcga tttcattagc cgaaaatggc tacttttatg tgatgcaccg atttgagcct 2723281 gagacacgaa ttgattttat taaagatatg aacgcacgcg ggttattctc ttctatcagc 2723341 gtgggcgtca aagatgagga gtatgaattt gtccgccagc tggcagaaga aaatctgact 2723401 cctgaatacg tgacaattga cattgctcac gggcactcaa atgctgtcat tgaaatgatc 2723461 cagcacctta aaaaacattt gccggacagc tttgttattg ctggcaatgt cggaacgccg 2723521 gaagcggtca gagagcttga aaatgcggga gcggatgcca ctaaagtcgg catcggaccg 2723581 ggaaaagtat gtattacgaa aatcaaaaca ggcttcggca caggcggctg gcaattagca 2723641 gcgctgcgct ggtgtgccaa ggctgccagc aaaccgatta tcgcggatgg cggcatccgc 2723701 acccatggcg acatcgcaaa atcaatccga ttcggcgcaa cgatggtcat gatcggttca 2723761 ctatttgccg gacacgaaga atcgccaggc caaacgatcg aaaaagacgg aaagctttac 2723821 aaggagtact tcggctcagc ctctgaattc caaaaaggcg aaaagaaaaa tgtcgaaggc 2723881 aaaaaaatgc acgtggcgca taaaggctca atcaaggata cactgattga aatggagcag 2723941 gatcttcaat cttctatttc ttatgcaggc ggaacaaagc ttaacgccat ccgcaatgtg 2724001 gattatgtga ttgtgaagaa ttccattttt aatggggata aatattaatc ataaaaaaac 2724061 gccaagtcag cggttctccg cttgagttgg cgttttctgc tacttcttca gcaaagtaag 2724121 cttatatttg ctttttgagt ttatcttcca tcagttctgc catttgtttt gcatttggat 2724181 tttcttcatt ttgcaactgt tcaatgacgt tcatataatc cgtttcattt cggttctggc 2724241 ttaatttata tgccgcttga atgtcttcca ccttaatctt aaatccaaca atacctttca 2724301 attcactttc taagagtttt ggagaaagct tatcccataa cacaggattg tcacgatgtt 2724361 tttcgtattt ctccaacatg attgttaatt cttctgctaa ttcatctttc tctaacatac 2724421 ttgcttttcc atacatgtgg acagcctgat aattccacgt cggaacattt tcgcgcgaat 2724481 accaggaaga agaaatataa gcgtgcggtc cctgaaacat cacaagcaca tcttcacagg 2724541 cttcaaacgt tctccactga ggatttccat aagcgaaatg ccccgtaata tagtaatgat 2724601 cgtctttttt attgaatcct aacggcaaat gtgtggcaat tggttttcct tgttctgttg 2724661 tgacaaccgt accaaaggag ttttcttgta caaaattcca aatttcttca gcatttgtga 2724721 ctttaaaata ttttggaata tacatcatca tccacccttc gaaaaatatt atatgagtgt 2724781 tttagccatg attaaatccg tttgttcttc atcacccata taaaatgagt gggcgccggt 2724841 ctgaacaaac cccattttct tataaaaggc aatggcattt tcattttttt cccacacacc 2724901 tagccaaatg ttctttttat tacgttccag cgcaatttct atcgctttat tcagcagatg 2724961 tttgccaagc ccatgttttt gaaagctgtt ctttatataa attctctcga tttcaagtga 2725021 ttcagcaccc atttcttcag actgagcatc atcgatattg acctttacat atccagcgat 2725081 ttcatgatca aagtaaataa aaaagaattg cgaagacata ttagataact ctttttccag 2725141 ctgctcagtg ttaaatgcgc tttctaaata ggctttcata ttttcaggtg agttctgttc 2725201 tttaaaagtg tcattgaatg tttcaatact caattgttga agtgtttgta aatcttcccg 2725261 gctgcatttt ttcattttta cactcattgt tcggattcag cccctttatt taaaattcaa 2725321 ttgtcttgtg tcccttttat atatttaaac acggaacaca tactgacctt gttaccattc 2725381 caaaaatctt cttcatcacc aactccctat cgtgattttg ttgtaaatgc aataaaatat 2725441 actccgcatt aaatatatcg taactttgct gtatttacaa caaaaatcaa acaacaaagc 2725501 agcgtttctc ttgccgaagt tcccggaact ctctgcatca tttccccata ataaaaacgc 2725561 ctcccttaac gatgatttat cgctaagaaa agcgtcagta atagttgcta tccgttttta 2725621 gtgcttagca ctcttcaggc ttgcctgcat tcgttgctgt tctgaacgaa gaaccgcagc 2725681 cgcatgaagc gatggcgttt ggattgtcga tggtgaagcc gccgccgagc atggattgtt 2725741 tataatcaat cacggtgccg ttcatgatgt caaggctttc tttgtcaact agaacagtga 2725801 tgccgtgctg atcaaacaca ctgtctgatt cactcttttc atgctcaaag cccatgccgt 2725861 aagaaagtcc gctgcagccg ccgcctttga cgcctacacg cagaaacgcg ttttcttctt 2725921 catgctcttt catcatatct tttatatgca aagctgctgc ttctgtaatt gttaccgggt 2725981 tgctcatcat tatgaacctc cttttaaaaa ccggttgctg tcttttatta taaacatgat 2726041 cgttccaatt ctcaaacaag gtgttttaca agaaatagac accctcacaa acggtttcag 2726101 ccggccctgt catcattaca tggccgttat ctttccagtt tatcaccaaa tccccgcctg 2726161 ctaaatgcac cgtgatgtct tgatttcgct ttgatacgcc gtttaataca gatgcgactg 2726221 ccgctgcaca tgctcctgtc ccgcatgcct gagtaatccc tgatccccgt tcccagacgc 2726281 ggaaatgcaa ttcttgttca ttcacggttt caacgaattc cacattgatg ccttccggaa 2726341 atctcggatc tttctcaatc accggcccca gtgtcgttaa gggtgcctgt tcaatgtctg 2726401 cgatcggaaa aacgatatgc ggatttccca ttgaaacggc agtgcctgtt agttctactt 2726461 caccaaatgc catcgtttca ttgattgtgt gctcttcccc gccgtcaagc ataggaagct 2726521 cggattttgt caagcgcggt tcgcccatat cgacagtgac cacattcact tttccgtttt 2726581 cgacttgaac ctccgctttc acaagcccgg agagagtttc aatcagaaaa gatgtttcct 2726641 caaccagctt atgctcatat gcgtattttg cgacgcagcg caggccgttg ccgcagtttt 2726701 tcccttcaga cccgtcatta ttaaaaatcc gcattttaac aggcgcttgg tctgatgggc 2726761 atatcaggat cattccgtcg gatccgatcc ctgtataaac agaagaaacc tgaattgcaa 2726821 tctctgacag tttttcttct ggaagctgtt cttcaaattg attcacataa atataactgt 2726881 ttcccaggcc gtgcattttg gtaaatcgaa atgagttcat aggtgcctcc aacttttttt 2726941 ctttttctta gtataaaagc tattataagc ggacacaata caattatccc ccgtttttca 2727001 tacataaaag ctccttgcac tgacgcaagg agcttttatc gtttatataa acatgccggc 2727061 aatggctgcg ctgagcagat tggctaatgt tcctgcaaga acagccttca ggccgagacg 2727121 tgcgatatct gaacggcggc tgggcgctaa accgccaagc gtaccaagca taatcgcaat 2727181 tgatgaaaaa ttggcgaatc cgcataacgc gaaactgata atggtagcag ttttcttaga 2727241 aaactcgccg atgtgcgaac cgaagttaga ataagcgaca aactcattca gcaccaattt 2727301 ctggccgata tagcttcccg cctgcaatgc ttcatgccaa ggcacgccaa tcaaaaaggc 2727361 gataggagaa aacacatagc cgagaatgga ttctaatgtt acgcctttta aaccgaacaa 2727421 gccgaaagcc ccgccgagaa taccgtttac tacagcgatt aacgcaacaa acgcaagcag 2727481 catcgcccca acatttaacg caatttgcag tcctgttgac gctccctttg cagctgcgtc 2727541 aatgacattg gctgcgcctt cgccttcatc cattttgaaa tcgcttttta cggtttgcgt 2727601 tttttccgtt tcgggtataa tcaatttacc aaagactagt ccagctggag cagccataaa 2727661 gctggccgcc agcaagtact caatcggaat accgagaagc gcgtacccaa acaaggtaga 2727721 tcccgcaact gccgatagac cgctcgtcat aatcgtaaac aactcagagc gcgtcagccc 2727781 ggcaatcagg ggtttgatca ctaacggaga ttctgattgt cctacaaaaa tattggcagc 2727841 agccgccaga gattccgttt tgcttgttcc aaggagcttc gacaatccgc cgccaatgac 2727901 acggaaaacg agctgcatga ttttcaaatg atataaaact gcaatcagtg ctgagaagaa 2727961 aatgataacg ggcagtacac ttaatgcaaa tgccggactg tctccgacct ttagaagcgg 2728021 tccaaaaata aaactgatgc cttcattcgc atagtcaatc agaagctgta cacggcttga 2728081 aaaccataaa aaaacagcgc gtcccgcttc ccatttcaac acgatgtatc caaacgccac 2728141 ctgtgtgcat aaaccaacga tgacggttct tatcttaata ttgcttttct tttctgaaaa 2728201 taaaaacgcg atagcaatga tcgcaactgc gcccagcagc ccccacagaa cattcatgaa 2728261 tactcgtaca cctcttaaat tttatttaaa aaaatatctt ttatacgata acaataatat 2728321 tttttgatgt ctacacattt ttttagttct tttgtacggc aaaataaaaa agggcctgtc 2728381 caggcccttt tctttaaaac attggatttt cttcaataaa ggtatatata ttctcaacaa 2728441 gctcagcagg cgtttcaccc atgacgactt ctccgtttac cagagcgaaa agcgattcca 2728501 tacatgtccc gcagtagctt aagcagccat attcaaggac atcaaggttg ggatccttct 2728561 ccaaaatcgc ccgggcttcc tgagagccgt gagccagatt gctgacacaa aattcaatca 2728621 ttggattcat gcggtttcac ctcacatatg tccattatcg cgaatttttc actattcgtc 2728681 aaagacaacg gatgattcaa aatttattat cgtaacatat tatttctcaa ataacgtttt 2728741 actaatttgt gttttcaggc taaattgtag gttattttga aactattatt gtgattttag 2728801 atcaaattcg atataattct agatgttatt ttacatagtt cgtattttct tcaatgtatc 2728861 tatcatactc ttcggattaa aggggaattc aaatgaaaaa attggtcttg atcggcggag 2728921 gttacgggaa catgcgcgtt cttcatcgct tattgccaaa ccagctgcct gatgatgttt 2728981 caatcacgtt aattgacaga aatccttatc actgcttgaa aacagaatat tatgcccttg 2729041 ccgcaggcac aatttctgac catcatatca gagtgtcatt cccagagcac cctcgcctgg 2729101 atgtccaata cggtgatatc acatcaattg atattgtaca aaaacaagtg ctgttccaag 2729161 atcgtgaacc gatttcttac gatgacgcca taatcgggct cggctgtgag gataaatatc 2729221 acaacgtgcc gggagcgcct gaattcacct acagtattca aaccatcgat cagtcccgcg 2729281 aaacctacca aaagctgaat aatctgagcg ctaatgccac cgtcgccatt gtcggagcgg 2729341 gcttaagcgg cgttgagctt gcaagtgaat tgagagaaag ccgtgatgac ctgaacatta 2729401 ttttgttcga ccgcggtaat ctcattttat caagctttcc cgagcgttta agcaaatatg 2729461 tgcaaaaatg gttcgaagag cacggtgtcc gcattattaa cagggcaaat atcacaaaag 2729521 tagaagaagg cgttgtgtat aaccacgatg atccgatttc tgcagacgcc atcgtgtgga 2729581 cagccggcat ccagccaaac aaagtcgtca gagacttaga tgtggagaag gacgcacaag 2729641 ggcgtattgt attaacgcct catcataatc ttccaggtga tgaacatctg tacgttgtcg 2729701 gcgattgcgc cagtcttcct catgcaccga gcgcccagct ggcagaggct caagcagagc 2729761 agattgtcca aatcttgcaa aaacgctgga atggagaagc cctgcctgaa tcaatgccgc 2729821 agtttaagct gaaaggcgtc ctcggttcac tcggaaaaaa agccggcttc gggcttgttg 2729881 ctgaccgtcc gctgatcggc cgtgttccgc gtatgctgaa atccggcttg ctgtggatgt 2729941 ataaacacca taacggttaa tgatagagaa gaaccgctga tcaagtcagc ggttttctgt 2730001 atacccatgc ttctccattt cctcataaac gtcttttaat tttggattgc cttcaccgac 2730061 aattttgtct tctacaagca caagcggata aaaatactcg tcatttctga ttttttccgc 2730121 aagctctttc gcatgttcat tgtcaggcgg ctcatgaata tcgatgtact gcatctcaaa 2730181 aggctgattt ggatattttc ttttcagcgc agcctcaagc cactcgtatg tatccttggc 2730241 tgtcggcata tttacacagc tcgcacaaac gttttctgcc ccgtacacgc ttagcatgac 2730301 tggtttcatc acttgtagac gcccccttct cctatgtaag tcctttcttt taagtataca 2730361 gagcctaagg gcgtttttat agaaaaaaac cgtttttgtg ttgaagtctg aatgtgctat 2730421 aatagggaaa gcaactttgc aaaccaaaca atagattttt attgttacac tgaatataat 2730481 ggttttatga cgacgaaagg agcgaatgtc atgactgaag ttgaaatgaa agaacaggtg 2730541 caggaagtac tggacaaact tcgtccgttt ttacttcgtg acggcggtga ctgtgagctt 2730601 gtagacgtag atgaaggtat cgttaagctt cgtcttctag gcgcatgcgg cagctgccca 2730661 agttcaacaa ttacgttgaa agccggaatt gagcgcgctc ttcttgaaga agtgccgggt 2730721 gtcgttgaag tagaacaagt cttttaataa agcagccagg ctgatatttg atcagcctgg 2730781 cttttttatt agagatgttg atcaaaccat gagctgatat aattcaggcg cttgatccgc 2730841 tgtcttgggt gtccggtgcg tgataaattg tgcgatgcat tcggaaaacg gacaagcttg 2730901 gtttccttgc ccattttttt cagagcgata aacagctgct ccgcctgctc gatcgggcat 2730961 cggtcatccc gctcgccatg cagtatcaaa agcggtgtct ccacgtttgc tgcgtatttt 2731021 aaaggagacc ggtcccagag cttttctgtg tcctcaaaca tgtcatgctc aagctgccag 2731081 tctgtaaaga aatagccgat atcactgacg ccgtgaaagc tgatccaatt tgatatcgag 2731141 cgctgggtaa cggcagcttt aaagcggttc gtctgcccga cgatccagtt ggtcataaaa 2731201 cctccgtagc ttccgcccgt gacaccgagc cgcttaggat caatatgcgg atctcgtttg 2731261 atagcctcat ccacagcctg catcacatcg tcataatcct ttcccccata atctcctctg 2731321 accgcattca caaattcctg cccgtagccg tggcttcctc tcggattgat ataaacgacc 2731381 gcgtatcctt tcgccgccag cacctgaaac tcatgaaaat atgtatgtcc gtacatcata 2731441 tgcggaccgc cgtgtatgtt aagaataagt ggatatgttg tctcaccttc catttgtgca 2731501 ggcctcatca gccagccgtt caccatcacg ccgtcttctg tagcatattg aatctcttca 2731561 ggtattgata tcgtatgctc cctgacaaac ttgtcattcg cgccagtcag ctgtttctct 2731621 tcctgtccaa gcgggatact gtaaagctca ctcggtctgt ccggctttgt cacactggca 2731681 ataaagtgct gttcatcagg tgaaagagaa aagctattga tgtactcttt ttccagacga 2731741 atcggataca caaggccttc aatcgaaata taatagatgc ccgtactgcc ttgatctgtg 2731801 ccgatgacat aaaacccttg gctgtccttt gtccaaatcg ggcgctgttc agcaccaccg 2731861 atcaatgaat ctccaatcag cgcatccgct aaatgaacgt ccagcatctc agtaagacat 2731921 gtgaggcggc cttgttcgat atcatagagc cacgcctttg agagcgtagc attcttatat 2731981 tccttttcat ttccaagcaa agcaagatac cttccgtctg gtgaaaatga gcttgatccg 2732041 aatgagccgc gatgaggtgt aacctgctta agatctccag actccagtga cattatgtaa 2732101 acatcatgcg gcttgctggc atcatctgtt tcagttaaat tagctgagaa aacaagccat 2732161 ttgccgtcag gagaaaaagc aggatcacca tgatcagctt tgtgacttgt cagctctttc 2732221 atctcacccg actttacgct gacaagcaca agctgggcat acgcacctct cgtcagccct 2732281 ttgccgtccc gtttgtagga gaggccttgc acttcaacag gttcatagct gtcctgctct 2732341 gttttttctc ggtcatcaat gctttccccc tctcccaaac tgacagtgac cagaatcgat 2732401 tcaccgtccg gggaccatag cggctttgac acgccatatg ggatatcagt cagttttctt 2732461 gcttctccgc cttcagtgct catgatataa agctgtgccg catcgccttc tcgatcagaa 2732521 ataaaggcaa gcgtgcgccc gtccggagac catcttgggt cggtgcttcg cttttctcca 2732581 tgtgtccaag gaacagatcc tcccgttttc gtttcataga tccatatatt tgatgtatac 2732641 gaatctttct cttgatttac ttgtgatttt acatatgcgg cacgggtacc gtctggggcg 2732701 tattgaggat cggtcacaga gacaatcgct gtgatgtcgt ctgcggttat cagctttttc 2732761 atattcatct cctccttttt acatgtattt cgtttttcta aataaaaact cctttatctc 2732821 cagcaaaaaa aagcgccctc cgctgacgct gaggaacgct tggcatgatc tatacacttt 2732881 ttacttgata taaaggattt cgctctatta tacttccctc tttcggaacg gtcaaagcgt 2732941 ctacttcaca atgagggaaa tgaagcgcga gctgttcttt tagctcttct ccctttcctt 2733001 tttcggtcat gacgagaatc gttgggcctg ctccgctgag agccgttcca tatgcgccct 2733061 tcatctcggc gacgtgctct acttttgaca gctcaggcac aagcatcgcc cggtacggct 2733121 gatggaacat atccttcttc atgattttcc cgacaagcgg ccaatccttg gacatgatcg 2733181 cagcaatgag gatattgctg acagcacttg cttttacggc atcggcatat ggaaactcct 2733241 tcggaagcac gtctctcgcg tctcttgtca gcacttcata aaaaggaatg acaacgacta 2733301 cgtcaatgtc agcattcggg acgcggatca tttgggtctc gtcatcctca tgcaggccga 2733361 tcacaagtcc gccgacgaga gaagcgccag cattgtccgg gtgtccttct tctagactcg 2733421 ctaaatgcag cttgtccgct tcagacagct ttaagccgca taattcatca gccagttcaa 2733481 tggccgctac aatcgctgcg gcgctgctgc caaggccgcg tgcaagcggg atgtcgctcc 2733541 acaccttcac atggacagga ggcatttctt ttccgtacaa atctgcggtc cgtttagcca 2733601 cttggtagat caggttatct gtacccgccg gaattccggc gactgtttct gtttcagcct 2733661 caaaagacca tttgtcgctt tcaaagacgg tcagcttcaa atatctgctg agcgccattc 2733721 cgactgaatc aaagccgggg cctaggttag ctgtgcttcc gggaacagtg acagagaaca 2733781 gcatgtcggc ttcgttcata cacgggccgc tccttttaca tattcaagga tgctgtcttc 2733841 atcagtcggc aatgtgacag gcttgatttc tgaaatgtcg accgctgtgt tcggatcttt 2733901 cagtccgttt cctgttaaca cagctacgac cttgctgcct ttcggaattt ctccggattt 2733961 cacctgtttc agcactcctg cgatagacgc gcaagaacct ggttctgcaa acacgccttc 2734021 tacacgggcg atcagctgat atgcgtgaag gatttcatca tcagtgactt cgtcaatttt 2734081 cccattggat tcctcggctg cctttacagc tttgtcccag cttgccgggt ttccgatacg 2734141 aatggctgtc gctattgttt ccggattttc aatcacttca ttgcgcacga ttgccgccgc 2734201 accctcagct tcaaagccgc gcattttcgg aaggcctgtg ccgtttttct catgatattc 2734261 cttgaagccc ttccagtacg cagtgatgtt tccagcattt ccgaccggga tcgctaaaac 2734321 atcaggcgct tcccccagct gttcgcacac ttcgaaggca gcagtttttt ggccttcaat 2734381 gcggtaaggg ttgactgagt tgacaagggc aatcggtgat ttctcacaga tggaacggac 2734441 aattttaagc gcatcgtcaa agtttccgtc aattgcgata atctcggctc cgtacatgac 2734501 agcttgagcg agttttccaa atgcaatttt tccgttcggg atgatgacaa tgcatttcat 2734561 gttagcacgg gctgcatatg ctgccgcagc agcggaagtg ttacctgttg acgcgcacat 2734621 aatcgtgtca ttgccttctt cttttgcctt tgccacagcc ataaccattc cgcgatcttt 2734681 aaatgatccc gtaggattga cgccttccgt tttgacatga agctcaattc cgagctgctc 2734741 agacagcttc ggcaggtgaa taagaggtgt gtttccttca tgtaaagtta gcgccggtgt 2734801 ttgatctgtt acaggtaaaa attctttata ttgatggata agtcctttcc acattagctc 2734861 caaccgttcc cttctacacg atatgtgctt ttgacttctt gaacgacttc caaatcattt 2734921 aggttttgca ggatatcact gaaatcagct tctgatgtat gatgtgtgac aattacgatt 2734981 tcagctaact catcatggcc tttaattggc agctgaagga ttttttcaaa gctcacgccc 2735041 cgctctgaga acacagatgt aattttcgag aatgaaccaa cctcatcttt tacatgaatt 2735101 cttaaaaact gctgtgcata aatgtcagac ggcgatttca tgtttttctc atattgcggt 2735161 ccgacaaagc tgttgccggt tacacctagg cgcatatttt tcatgacagc gacgaggtca 2735221 gaaacaacgg atgtcgctgt cggcatgctt ccggctcccg gcccgtagaa catcgtctca 2735281 ccgacagcct cgccgtatac ataaacagcg ttaaactcat tatgaacagc agaaagcgga 2735341 tgatggtcag gaagcagtgt cggctgtacg ctgacctcga ttttgctgcc gtcacgctga 2735401 gcaatcccga tcagcttcat tgtatagccg aggcgtttgc tgaagctgat gtcctcgtct 2735461 gtaatttggg agatcccctt tactttgacg tcttccagat ccacgttcat cgagaagccg 2735521 aggcgcgcca atatcgccat tttccgtgcg gcgtcaagcc cttccacgtc agaagtcgga 2735581 tcagcttcgg caaaaccgag atcctgcgct tccttgagca cttcctcgta tgggcttttc 2735641 tctttgatca ttttggttaa gataaagttt gttgtgccgt tcacaattcc catcattttt 2735701 gtaattcgat ctgatgagag gccttcctct aacgtgcgca gaatcggaat cccgccggca 2735761 acactggctt caaagtagat atcgcatcca ttttccttcg cttcggcaag cagctcggag 2735821 ccgtacacag ccattaagtc cttgtttgct gtgacaacat gctttttcga tctcagcgcg 2735881 tcgaccaaat attgttttgt ctgttcaacg ccgccgatca cctcgatgac gacatcaaca 2735941 tctggatcat caatgacatc atacacttct gtcgtgagca cttccttcgg caaatctact 2736001 tctctctttt tctctaaatc ttttacaagc acttttttta tcgtaaccgg acagccgacc 2736061 tgatgcataa gcttatcctg atggtcttga ataattttaa cgacaccgct tccgacggta 2736121 cctaaaccta aaagccctac acgaatcgct ttcaaaaaaa ctccaccttt cttttgattg 2736181 tcctcttgga aaagacaatt gttaactcaa cacagacata taagttacaa acattatata 2736241 agcccgctcc tgttttgaca agacatcatt aggctgaatt ttgcgaatgt aaacgcttaa 2736301 cgcattgata tgacaagatt ctttattttc taattatttt tgtcagattt tctcctcacc 2736361 ttgagctgcc tttgccgagc cagctgacgc gtggaacaaa cagcttctgc gcccgcatat 2736421 tcatgaattc ctgcgctgta ttgagaaatt gttcataacg cccacagtca ttaagaatga 2736481 agtcaagctg ttcttcaaaa taatgctttt ctgattctga tgacatgtaa tagctttcta 2736541 cgatttcaaa ataatgaagc gggaaaagca gacggctgta taaaaggcgt ttcgaaaatg 2736601 aagacagcgg tgtgacttgc tcgtattcct gtaaaaagag aaagccctgc tgattaaaat 2736661 cttgtctgtg atgcaaaaac gtatgcctca tatattcagc caaatcacgg gaagcgtggt 2736721 caaacaccca atccgccgga atcctgatca atgattccgg tgaccatgta tgcctttcca 2736781 tccgctgatg gcatatcgtt cctgaatcag cggcttgggg cttgtcatcc agctcagtgt 2736841 ccactaaata ttgtatcgcg ttttctgaca gtcctaaata atatggaaat gattcgatca 2736901 tttttttatc gaatggctca tgcggagggg tctgaacctt tctctgccaa aatgcttcca 2736961 gctgatcaat tcgttttccc cacagatcct tccactggcc gattcttccg gccgccttca 2737021 cctcatatgg atatcctcgg ccttttcggt gaaattccgc aagctccgct ccaatggaga 2737081 acgccctgtt tgaataaggg ggggccgcct tcagcagagc gtacgttttt ccctcatgtt 2737141 caaatgtcag ttcaccttct tttgtaaaga taaaaaccga aacgtatggg tcactttgtt 2737201 cttgtaaata ctgactcatg taataaagct ccgccagctc tgtttctgag aattgggaaa 2737261 cggggacaat cagaaagtat gaattaggcg tctgaaagca ttgatatgtg tgctggtaca 2737321 tggaaagctg cctgatgtga atgccgtatt tttcttttat tgtacctttc accatgatca 2737381 cctgcctgtt gaattagggc tcatcacatc gtagtcatac acagccggaa ttatgaatac 2737441 atattttaat ccgaagaagg cgcaagaaaa agtcgtaaac ttctcaagca ttttgtataa 2737501 actagtaaaa aagattgggt gaagctgatg tcagaaaacg aacaattcag tcagatggaa 2737561 gctaaagcaa gagcacggat gaaggagcgc ggcgttgagg tatcagacat tgccgagctt 2737621 gtcttttttc tgcagaaaaa atatcatccg gatttaacca ttgatgaatg cacgctgaac 2737681 gtcaatcgtg ttctcgcaaa acgcgaggtg caaaacgcga ttttaacggg cattgaattg 2737741 gatgttcttg ctgagcagaa aaaattgtct gaaccgctgc aaacgatgct ggaaatagat 2737801 gaaagcctat atggagtaga tgaagttctg gcattttcca ttgtgaacat ttacggatcg 2737861 atcgggttta cgaactacgg ttacatcgac aaagaaaaac ccggaatcct taaacgattg 2737921 aatgataaat caaccggtga atgccatacc tttttagatg acatcgtcgg agcgatttcc 2737981 gccgcggctt caagcagact tgctcaccgc gcgcggcata cagaataagg gcaccctttt 2738041 agggcgccct tttttcaaat gtatggaatc cattcagtca gagagtcaat ggcgtgagtc 2738101 ggtttttcca tatcgtctgt catatgttct cttttcgtta cgcctgtgtg aacgagcagc 2738161 gtatccatac ccgcgttaat gccggccata atatcagtgg cgtagttgtc gccgaccatg 2738221 agtgtttcag acacatctgt gccgagaacg cgcatcgcct gctccataat aattgattcc 2738281 ggcttgccga taaatacagg ctgtacacct gtagatacgg ttaacaccga tgtcagtgag 2738341 ccgtttcccg gcaggagccc tctttcagtc ggaatcgcaa tatctccgtt agtggaaata 2738401 aagcgggcgc catttctgat tgccaggcag ccaacagcaa atttttcgta tgtaatggaa 2738461 cggtcgatgc caacaacgac aaaatccgcg ttttctccgc caaatgtcag gccgttttct 2738521 tcaatcgcct ggcggattcc ttcctcccca atcacataca cagacgcgtc ttttttctgc 2738581 tgtgcaatgt gctgggcagt tgccatgctg gtcgtgaaga cctgctcttc tgttgccgga 2738641 atatcaaaag acacgagctt gtccgctacc tgcttcggtg tgcgcgaaga gttgtttgtc 2738701 acgaaaagat aaggaacgcc gcgatctttc agcgttctga caaattcaca cgcctcctcg 2738761 attttttccg tgccattgta catcgttccg tctaaatcaa ttaaataccc tttatatgtt 2738821 ttcatatcca acactcctgt ggctttccag ttgttattta aacgcggaaa caggtcctag 2738881 ctctgtttcc aaatagcttc tgatccgttt cgggaagtcc tgaagagctg tttgatgcgc 2738941 cttgatcagc ctgtaaagct cgccgctgtc agcgagcaga tactgttgaa ccaacgtttt 2739001 gcggtaggcg atcaattttt tgagctcatc accctctttt tccgtgacaa ctttctcatc 2739061 aacaagtata tccataatgt cgtcatagct gcccgggtcc cgcataataa agccgtcaat 2739121 catgtcattg cctgtatcca aaatgcattc gattaacaga tggcctatac gctgaagtgc 2739181 caattccccg atttcagact gccagtctgt ttgtgagtca aatagcgcca gctggtgctc 2739241 gaagaaccct agtgtttttt cgattttgct tctgtcaaca aaatacatga cagcatcccc 2739301 tttgtgtata tttattttct gatccgtttc aagacaaaat acgcacagcc gaaattgcag 2739361 tattcgtaaa tatattcatc taatgtgctg attttcgttt cgaaggttgc cttttgattc 2739421 tggtcgtcaa agaagccctt gagccttaac tgaccgtatc cccagtctcc cacaatataa 2739481 tcgtatttat ttaatatatc ggagtagcgg gctttaaaag cctcttcgtt gaagccgtct 2739541 ttgaaattgt gcaccaattc aaattcggca ttttgaataa gaatcatgat ctcacctctt 2739601 ttttcactca ttcctatcat aattcattgc cccgtcccca tcaattgcta aagaataaat 2739661 catgcgattt ggctacccta cacatgagga gggattgata aatgaaacga accgctgtca 2739721 gcctctgcct gctgaccgga ctattatccg ggtgcggagg cgcaggattg gataatgccc 2739781 aaaatgtccg gaatcagacg cagaatcaaa ccaaacccat tcatgtgtcg gaccgcaacg 2739841 aggcttttaa caggcataat gagaacgaac aatttggcta tgtccgctat caaaaagaac 2739901 aatttgacgg agaacagcag aaaacgccgg tgatgaaccg ggaagaaacc gctcacatga 2739961 tatcaagttt aacggttcag ctcccccata ttcaagatgc tgcgacattg gtgactgacc 2740021 gagaagcgct tgtcgtatac aaaaccgatt ctaaaaaccg ggagctgacc gccgatcagg 2740081 tgaaaaaaac agcggcttct gtgataccgc gatactatca cgtgtatatt tccgataatc 2740141 caaaccatat gcaatccgtc gaaaattaca gcaatctcgg ctctggttca agggatatta 2740201 gagagatcat gtcggggacg attcaagaaa tgaaaacctc cccgcaagga agccctgtct 2740261 cagagaatga aaatgccaat ggagaaacgc gtcaggacat gaaaatcgat aggaatgaca 2740321 aaaacgccag atgatctggc gttttggcat tatgcttgtg cttgacgctt tttagatgct 2740381 tcgtttactt gttcatccgc atggtaagag gaacggacaa gcggaccggc ttcacaatgg 2740441 ctgaagcctt tttgcatcgc gatttctttt aattctgcaa attcatcagg atggtagtat 2740501 ttttggactt tcaagtgttt cttcgtcggc tgcagatatt ggccgattgc cataatatcc 2740561 acgttgttcg ccaagaggtc gtccattact tcaataatct cttcttttgt ttcgccgagt 2740621 ccgatcatga tacttgattt tgtcggaatg tcaggctgca tttccttcgc acggcgcaaa 2740681 aattccaatg aacggtcgta cgtcgcacgc gcgcggactc ttggcgtcag gcggcgaacc 2740741 gtttcgatat tgtgattcag gatgtctggg cgtgtatcca tcaaggtttt taggttatcg 2740801 tagtttccgc ccatatcaga cggcagcacc tcaattgttg tgaacgggct ttttctgcgg 2740861 atcgcacgga cagtttccgc gaaaatgcct gccccgccat ctttctgatc gtcacgcgca 2740921 acagccgtaa tgaccgcgtg tttcaaattc ataagcgcga ctgaatccgc tacgcgttcc 2740981 ggctcttgca gatcaagctc agttggaagg cctgttttga cagcacagaa acggcatgct 2741041 cttgtacaaa cagaacctaa aatcataaat gtcgctgtac gtctgaccgc ccagcattca 2741101 tgaatattcg gacactttgc ttcttcgcat acggtatgca ggttgttttc ccgcatgagt 2741161 tttttgagcc ctgtatagtt ttcatttgta tttaatttaa ttttaagcca ttcgggcttt 2741221 ctgaggtgtt cgtctttctt tgccaattcc catcatctcc aatatccaat atactcaatt 2741281 tctgacacga aacattctga aaacgagaaa ggtgcaggtt ttagttctgc aacaaaaata 2741341 atgtttttct aactaaagaa agtcttttct ttagacactt taacatagga aaaatttctc 2741401 gacaagggaa gatgattact gacattttta agccgggttg ccgcaaacta tgtgtattca 2741461 atatgaaagg agattatttt gtgaaagttt tgttatccgc tcttcttctc cttttgtttg 2741521 catttgagcc ttctgcgtct ggaaaaaaac tttcagatcc agtgctgtcg aaacggatgg 2741581 aattatatca taaaatcgaa gctgtgacgc agatcccttg gtatgcgctc gccgctgttg 2741641 atcaatacga agaaaacgtg cggagcaacc ggaaagatct gcctgaaaag gcgggaatca 2741701 tcagcatcta tatacccgat gatatctgga gcgggcctga aaacccgaat ccgaaagacg 2741761 atgcgccgtt aagcattaaa gtgtttgacg gaatcggaat ggatggcgat ggagacggga 2741821 aagccgaggt cagcaacgat gaagatatct tgtatacgtt cagccaatac ttactgtcgt 2741881 atggcacaga tgaagacaac atccggatcg ggctttggaa ttattaccgg cgtgatcaga 2741941 cagtggggat tatatctgaa ttcatgaagc tgtttaaagc ctacggccat attgatctgg 2742001 gcgagcatgc attcccgctt ccgatcagaa ccgattacag ctaccgaagc acgtggggag 2742061 atgcccgcgg cttcggtgga aggcggattc atgaaggtac ggatatcttt gcccattacg 2742121 gccttcctgt caaatccaca tgttacggcg tagttgaaat gaagggctgg aaccgcttcg 2742181 gaggatggag aatcggcatc agggacatta acaatacgta tcattatttt gcccatctca 2742241 atgggtttgc caaagggatt aaaacaggac aaatcgttga gcctggccaa gtgatcggat 2742301 cagtcggcag ctccggatac ggcccgccgg gaaccgccgg gaagttcccg ccgcatctgc 2742361 actatggcat gtacaaagat aacggaagaa ccgaatggtc atttgatcca tacccgcatt 2742421 tgagggcgtg ggagcgatat gaataccaaa aaaagaagta acaaaaagcc gcctcttcaa 2742481 caggcggctt atttgctgct tttttctttt tttgaatcgg caccgttttc tttgctgctc 2742541 ggaagctgga cagaaggcgt gacacccgag ccgccgcttc cattataaaa ctgcggcact 2742601 tcgccctgca ctgctttaat cgatacagga acattatttg tgacgacagc ggttttgctg 2742661 gcaaatggaa tgatgacctt cactttaatt tcgacaaaga tgctgatatc aataagtgcg 2742721 ttatttatgc catacggctt gattttggtt ttgacatctg taaaagcgtc accgattaaa 2742781 ttgaaccgga ccgggatttt cggcccgagg tttccaagaa ggctgttgcc ggttacctgt 2742841 cccagcggaa tgttgatcat aatgttttca ctggcgccgc tgtgtccggt atgggtttcc 2742901 atctctttca aatgagcctg aagctgcttt gtcacttttg ttttcacact gtttacaacc 2742961 tgtgtattaa aatcgattgt cgttaagttt ccgttttcat cagaattcat ttgaaacata 2743021 tctttcatat tttcactgtc agacatatag tcctcaatcg aatcctggat cacctctgtc 2743081 gctatacgct tcgtttccat ctcgccgatg tccattaaaa caggtttgat cgagccattg 2743141 atcatccaaa ggctgaccgt tgttgacagg ataaaaaaga caacggacag gagcatcacg 2743201 taacggaaag gcaaaggtcc tctcttgcga aaagggccgc gatatcttgg caagaaaatc 2743261 cccccttaca tatcacaatg tatgcttgta agaggggaca tagtaatagc cggggccaat 2743321 ttattttatt tcatcatttt taaaagcgct tctctgccgc tcatgccgac tttgatgcca 2743381 agatcttccg cagcgtacgt gacggattct aaaggtgcgt ctaacagctg gtcaatggtg 2743441 cggacaccaa ctgcgcgtcc cgccacgatg ccgcgctcct ttaatttttc attcagcagc 2743501 gccacatcaa gcgcgccgca cataatgtat ccgtgatcat tggcgacggc cataaaattc 2743561 gttttgggaa gctttactgt cacagctgta aaaggctgtc cttctatcat gatcggtgtc 2743621 aggtttacca cgtcaaccac tcccttcatt catcacttta tgatgaaggg cacagcttgt 2743681 tgtgggctga ctgccttatt gtgcaagctt ccaagcaagc agatcccgca aaaattccgg 2743741 cataaaatat tctttttctg cagcgtcgcg aatcaacgga aacagtttgc cgagcgtaaa 2743801 catatcaagc accgcaacgg agtattgttt atgtttttca atatcttccc cgttcagtgt 2743861 gatccgagtg acgtgggtga tcccgtcatc gagccgtttc gtttctacct caacgccggc 2743921 atacaccatt ttccccatca cttctccgcg gaagccgagt cctttgatcc ggagctgctc 2743981 catttgttcg gaagcggcat ggacaatggt ttccttcagt tcttctcccg tcaggcggac 2744041 agccaccggg ttgatcggat gcggacagat gcggtgcaga tccagctttg tcacaggacc 2744101 tgcttttagc ggaccgagaa tgacacctga attgaccata ctgatgtccg tctcgcacca 2744161 ttcctttaag gcgtatgcca aaagcaaagg cagctctgat tcttcaaacc acttcacctc 2744221 agcatcttgt gcaagctctg caacggcatc ggacagtttc tcctcggctt cacgttcttt 2744281 ttcattgaga aacgctttag tttctgcgga ttctcctgtc cattccgcca tgttctgcac 2744341 agaagccgtt ttgctgttga tgcttcgctg tacgctgtcc accgtgattt ctacacagcc 2744401 gacataatgc ccgtatttct cggcgctggc cagcagtacc ccattaacca cttgtccatc 2744461 ttcgagcaaa tgatgggtat gtgattcgag gattacatca atctcaggca ccgcttcagc 2744521 cactgcttga tcatcaagaa tgcctaaatg tgacagcaga acgataatat cagcctgccc 2744581 tttcacttcc agaatggttt cctttatgct ttcaagggca tccgtaactg tccatcccag 2744641 cttgtcatat acaggataat acggcacagt tacacctaag aaagcaatgg acataccgtt 2744701 tttcaatgat ttgatatggt aaggcaccgc ccaggacgga cggtttccat ttttatcaaa 2744761 caggttagag acgatgacag gaaattcagc atgatcatat aaggcagcaa gctcttcatg 2744821 cggaagcgta atcccttcgt tattgccgat cgccgctcca tcaatgtgaa ggcggtttaa 2744881 gagatcgaca ttcgcttttc cgaatgtcgc ctctgtcacg aattgaaaac gatcaagatg 2744941 atcgccaata tcaaaaacga gcgtctcttc gccgtctgac tgatgctctt ttcttttctg 2745001 ctcgatataa tctacaattt tcggccagtt ttcaaaatgg ctgtgcaaat catttgtatg 2745061 atataagcgg agcttctcct tcataatatc tctccctaat cgttcagctg aaaatgcctt 2745121 cataaatgag ctggcagccg atcaaaatca atacgatccg catgatcata acgatcgttt 2745181 tcgtctgcat ttttctgttg atggcggcgc caagctttcc gccgaaccaa gcgccgggca 2745241 caagcgcgag ggcgtacagc caattgacgt gcccggaaat catatgtgaa acagaccctg 2745301 tcatagaaga caggaaaata ataaacatgg acgttgccac cgcaaccttc ggcggaaaca 2745361 gaaataacag catcatcgcc ggaaccatca gtgatccgcc gcctataccg aaaagtccgc 2745421 ctaaaaaacc gacaacaaag gcaatggcaa taccgacaga ggcctgatat gagtacgtat 2745481 aaggctcacc ggcatcatcc tgaaatgtcc ggataattcc tttgtgcgct ttgttgattg 2745541 gccgggcttt cgctttcagc attaaggata atgaaatcag aatcataaaa atgccaaacc 2745601 aaacggaaaa cgagtttgaa ttgaacagct ttgacacgta agccccgatc atgctgccgg 2745661 gacccgaacc gataaagaaa atgagtccgc tcttataatc aactgtttta tatttaatat 2745721 aagccaaagt tgaagaaagg cccgtaaaaa taatgaccaa aagcgaagtt ccaatcgcaa 2745781 cctgcggcgt cacatcctga aacagctgcg tcactgtgct taaaaacatc agagatggca 2745841 caatgacaat tccgccgcca agcccgatca gacttcctac cgtacctgcg attaatccca 2745901 gtacgaccaa aatcacaaac gacatcaatc aaaacctctt ttctaaaata aatcgagctg 2745961 tctcggagca agtccgctgt actcgatatc aagcagttca agcatctgct tgccattatc 2746021 cgcagcgtca ccgccggaat tgttgttgaa caggacaaaa acatccttac attgctgctg 2746081 caattcattc aggtgctttt tccaatcctc cagctcctgt tggttgtagc ggtataagta 2746141 cctgacctcc cgccagtttt tcccgccatc aggcttcatc cagccctgct tgttgcgtcc 2746201 gtgaaacctg acgagcgttt tgttttcatc ggtcgcgcgc aacacggtcg gaacgctgcc 2746261 ttctccgatt tgcggttcat cacagacact gtgaatccag ccttccgctt tcataaatga 2746321 aagcgtctgc tcataaaatg gcggcgagaa ccaggaacgg tttctgaatt caagcgcgca 2746381 aggaatatct cccatttggt gcttacacca tctcaaatag gcgacattct ccttcttgca 2746441 gtcaaaccac ggcggaaatt gaaacagcac catggcgagc ttattgctat gtaaatatgg 2746501 cgttaaagac accttaaacg catcaaacat ctcctctttt gagtcaaagg gaatttcgcc 2746561 gcgctgatgc cctgtcatgc cctgatatgc tttcacgata aattggaagg tttcgggcgt 2746621 ttccttcacc cacttttcat tattgcgcgc cggctgaatc gcgtaaaagc tcgcgtctaa 2746681 ttccacgatc ggaaaatggg aggaataggc ctgcaatttt ttctggctgg ccgttttcgg 2746741 cggatagatg ctgtcatgat ccccccatcc cgtcagtccg atataaatca cactcattca 2746801 cctctcttcc agtttatcac acgtgttttc aggtttcctc ggaaatgctg ttcatatggc 2746861 gggaaaatgc ctcacgcaaa tgctgatatt gttcctcatt cgtatctaaa aacgcctctt 2746921 ctcttgagga aggaatgtgc tgatattcaa taggcgcctg aaactgctca ctcgtaaaat 2746981 cgtacaccac accattgatg ctgttataaa aatgccagct ctcatcgact cttgttttga 2747041 aaatcgtgcc gccgaaatgg tcttgaatca ccaatgccgt cacgccgcat tggccgcatg 2747101 acgggcattc ttccgtccat ttagagctcg aatggcgcga ccaggattgc ttaagtatgt 2747161 atttgacatg ctccattgcc tccgcctcct ttaaaaaaag ataccacgtt gatgagattt 2747221 taaaaactag aacggaggaa atcaaaaaac ccggcggtaa aatccgccgg gcttacgaag 2747281 gaacgaccag agctccgtca atttcagtga ctttttcccc atcattgtac acgcaccggc 2747341 ctttgctgta agtggccgaa atgctgcagg gaaatgtatg tccttcgtaa atgctttttt 2747401 tatgctttgc aaacatcgat tctcttgtaa cagtgtacgg ctccatgctg acgagcacga 2747461 aatctgcatc acaccccgcc tcaagccgcc cttttttctg aaggccgaat cgttttgcag 2747521 gggccgccgc tgtccattct gcgatggttt caaatggaat ctgatgctca agcgccagtt 2747581 ccagcattcc taataaagtg aactgcccgc cgctgattcc gccccatgat aaaaacatgt 2747641 tatcctcccg cttcaaggat ggacggcaag gggaatggtc tgaggaaacc atgtcaatgt 2747701 ccccggcaat gagcgtctcg atcagcgtct cttttgattg ccgtgaccgg agcggaggcg 2747761 cgcattttgc gacagagccc ctttgccgta aatcgtcatg gctgaacaag acataatgcg 2747821 gacatgtttc aaccgaaaca tcaagacctt cctgtttcgc ctctctgatc agccggaccg 2747881 ctttcgccgt gctgatatgg acaaaatgaa ccggacagcc tgtcaccttc gcatactgaa 2747941 tcgtgcgata caccgcttca acttctgctt cctccgggcg ggaggcggcg tacgcatccg 2748001 catccacctt tcctttattg gccaaaacca tctgcaagta gcttgtgatc gcgtcgcttt 2748061 ccgcgtggag agcgaggatt tttcctgcag ccgcgatttc tgccatgcct ttgagcaatg 2748121 tccgttcatc aacagagcgg aactcatcag tgcctgactt tgataaaaac gctttaaacc 2748181 cgatcgctcc cgcttcagcc atcggacgga tgtcctcgat atggcctggc acaaggccgc 2748241 cccatagcgc aaaatccacg gcagattttt gcctgcctag ctcagctttt gcgagaagat 2748301 gctctgccgt cacggttgat ggaatacagt tgagcggcat atcaaaatag gtagtgcaac 2748361 cgcctgcggc catcatttga gaacctgttt caaacccctc ccaatcctcc ctgcccggtt 2748421 cattaaaatg aacatggcaa tctatcacac caggaaacac gtatttcccg tctgcctgga 2748481 tgatttccgt cccgcttgct tcaatgtcag aacctatctc ggcaatgaca ccgttttgaa 2748541 ctacaatatc agcttctata acgccatctg gcgtaactgc cttcgcacct tttatcacca 2748601 tatcgtaagc catattgatc cccccatgtc aggatgacga ttttccatgt cagtttatgt 2748661 aacacaacca gttctatttt caacagttta ctgctactat gatcgtatta catcagcaaa 2748721 accgctagaa ttcctattga aaattattca ccttaaccaa tgtttttata gaaaaggaga 2748781 atgcgctatg aatattcttg atgtgatgaa aataccggct tttgaaaacg ccaatttaat 2748841 cgctggaaaa gcaggagggg aaagagaggt tcagcatgtc aatatgatgg acgctccgga 2748901 tatcgtagac tttttgcata agaatgaatt gctcgtcacc accgcctatc acctgaagga 2748961 tcacccgcat caattatctg aactgattcg gcaaatggca aaacgcggct gcgcgggcct 2749021 cggcattaaa acaaagcgct atctggaaga tatcccgaag gaaatcatcg aactggccga 2749081 ttcatatgcg tttccgatca ttgagcttcc ggaacacatc cgactcggcg atattgtgaa 2749141 tgccacactc agccatattc tcgatatgcg ttctaacgag ctgcagcaag ccatttacgc 2749201 gcacaaaaaa ttcacaaacc acattatgag cggcaagggg ctgcaatccc tcctcaaaaa 2749261 ggtgtcagac atccttcagc ttcccgtgct gctgcttgac cagcatgcca aaatgctgtc 2749321 tgcgtctcat cagatttcag ttgagaccga aaagctgaaa ggcaccctga ataccgtatc 2749381 cgggccattt ttcacttgtt tctctacaat ctcagatcag aaaacatatt ctgtcctgcc 2749441 tatttataat cacgaaaaaa actgcggcta cctgctgata cccgacatgg tgcaggcagg 2749501 cgacaaagga ttgatcctca cgattgaaca agcggccaac gtcatttcct ttgaactgct 2749561 gaaggaaaat gcgctgaagc agttcagccg gcgggcccgc aatgagtttt tcaacaattt 2749621 tattgagcgg accttttctt cagatgacga aatcaaaaac cgggcgaaag aattcaagct 2749681 gcgctgggat caaaaataca tgtgcatcgc cggcaaactc gatcgcaatg acgaatcaat 2749741 cagctttaca gaaaatcagc tcgcttccga cagcgtattc gaatttcttg aaggtgaatt 2749801 atcagccttc ccgtttccac ctcacttctt tatgaaagga aatgtcggca ttattctaat 2749861 cgaggcgaca gacagctgga gtgaaatgca cgcctcggtg atcagctttt tagaacagtt 2749921 tcaaacacag gtcagcgctc aatttaaacg aaccgtgtcc tttggcatca gcaatatctg 2749981 ccaaaagctc attgatgttc ccgacgcttt cacagaagct tctgatgctc tgcaatcggg 2750041 gcatttgtca agaagcaccg catttatcca ggtgtatcac gccaaagatg tgcctgagct 2750101 tctgcgcttg ctcccagttg aggatttgaa gaaattttac aactccacgc ttcagagcct 2750161 cgctgaaaaa cagcaggagg atcaaagcct gcttcatacg ctttccgtct atttagagac 2750221 acactgccaa atttcagaga cggcaaagcg tctgtacgtt catcgcaata cggtcatata 2750281 ccgccttgaa aaatgcgaag agcttctggg gaaaagctta aaagatcctg aaacaacgat 2750341 gcgtttgcgg cttgcattac gtatgcagcg gctgatcagc taaagtttgt tacattttct 2750401 tacaaaacga atcgtttttc gtcactttca gcaatcacac ctgtcttttt cagctactgt 2750461 atccaatgac acccctcgac cggaacgata ttatgttact aaagttcaca tacagggagg 2750521 gactatagtg aaaaaaagat cgtttaaggt gtttacactt agcctgcagc atgtgctcgc 2750581 catgtatgca ggtgcgattt tggtgcccct gcttgtcggc agggcgctga atgtaacaac 2750641 tgaacagctg tcctacctat tggcgattga cctgttaaca tgcggcgtcg ctacgctttt 2750701 gcaaaccttg cgcggaacat acatcggcat cgggcttccc gtcatgcttg gcagttcatt 2750761 tgtggccgtc accccaatga ttgcaatcgg cagcaattac ggcattcacg cgatttatgg 2750821 ttccatcatt gcggccggtg tgttcatctt tttgtttgcg cgttttttcg gcaagctgac 2750881 tgtgttattt cctcctgtcg taacaggtac cgttgtgacc ttgatcggcc tttcacttgt 2750941 tccgacaggt gtgaaaaata tggctggcgg cgaaaaaata aacggcagcg ccaaccccga 2751001 atacggttcg ctcgaaaacc ttcttctctc tgtcggtgtc cttgttctga tcttagtcct 2751061 caaccgcttt ctcaaaggat ttgcccgaac actgtccgtt ctgatcggca tcgccgccgg 2751121 aacagcggca gcagcgatca tgggcaaagt cagcttttct tctgttacag aagcaccgtt 2751181 cttccaaatc ccgaagcctt tttacttcgg agcccctgcg tttgaaatcg gtccgatctt 2751241 aacgatgctg atcgtcggaa tcgtcattat tgtggaatca accggcgttt tttacgcaat 2751301 cggaaagata tgcggcagac ctttaactga caaagatctc gtcaaaggct atcgagcgga 2751361 aggaatcgcc attctcatcg gcgggctgtt caatgccttt ccttataata cctttgcgca 2751421 aaacgccggc ttattgcagc tgaccaaagt gaaaacaaga aacatcgtcg ttaccgcagg 2751481 ctgtatcctt gtctgtctcg gactgattcc gaagattgcc gcccttgcat ctgccgttcc 2751541 tgctgctgta cttggcggcg cgaccgtcgt catgttcggc atggtgattg cctccggcgt 2751601 caaaatgctc agcacagcgg atctcaaaaa tcaataccac ctcctgacca tcgcatgctc 2751661 aatcgcactc ggcatcggcg ccagcacggc ccccgggatt tttgctgaat tccccgctcc 2751721 gatccggatt ctggtcagtg acggcaccat caccggaagc ctaaccgcca tctttttgaa 2751781 tctatttttc agcttgcgcg acaaaaaaga attaacagca cagcaaacag aacttccggt 2751841 attagaacat acactcgcat tagaaaaaga ggtgtaaaaa agatgaagga acagcacaat 2751901 gccttacagc taatgatgct ggggcttcag cacatgcttg ccatgtatgc gggagccatt 2751961 ctcgttccgt tgatcgtcgg agcagcgatc gggctgaatg cggggcagct gacgtattta 2752021 atcgcgattg atttgtttat gtgcggggcg gcaactcttt tgcagctctg gagaaaccga 2752081 tatttcggca tcggccttcc cgttgtgctc ggatgcacgt ttaccgcagt cggcccgatg 2752141 atttccatcg gaagcactta cggtgtccca gcgatatatg gtgccattat cgccgcagga 2752201 ctgattgtcg tcttagccgc gggcttcttc gggaagcttg tccgtttttt tccgcctgtc 2752261 gtaaccggat cagtcgtcat gatcatcggc atcagcctga ttccaacggc aatgaataac 2752321 ctggccggag gtgaaggaag caaagaattc ggctcactcg acaacgtgct cctcgggttt 2752381 ggcgtcacag cttttatctt attgctgttt tatttcttta aaggctttat ccgctccata 2752441 gcgattttac tcggtcttat cgcaggaaca gcggctgcat atttcatggg aaaggtcgat 2752501 ttttctgagg ttttggaggc gtcttggctt catgttccgt ctctgtttta tttcggaccg 2752561 ccaacctttg agctgccggc tgttgtcacg atgcttctcg ttgcaattgt cagcctcgtt 2752621 gaatcgacag gcgtttattt tgccctcgct gatatcacaa accgcaggct gtcggagaag 2752681 gatctggaaa aaggctaccg ggcagaaggc cttgcgattt tgctgggcgg cttatttaac 2752741 gcgtttccct atacagcttt ctcgcagaat gtcggcatcg ttcagctctc aaagatgaaa 2752801 agtgtcaacg tcatcgccat cacaggaatc atactggtcg cgatcgggct ggttccaaaa 2752861 gcagcggccc tgacaacagt gatccccacc ccagttctcg gcggcgcaat gatcgtcatg 2752921 ttcggcatgg tcatttctta cgggatcaaa atgctatcca gcgttgacct tgattcgcaa 2752981 ggcaacctgc tgattatcgc ctcttccgtc agcttggggc ttggcgctac aacagttccc 2753041 gcgttgtttt catctctttc gggcgcggcc tctgtcttgg caggaagcgg aattgtgatc 2753101 ggcagtttga cggccattgc actgcacgct ttttttcaaa ccaaacagcc gaatagcgca 2753161 gacataaaaa cgtaaaggaa gatgccaatg ttcacaatgg atgacctgaa ccaaatggac 2753221 acacaaacac tgacagacac acttggctct atttttgaac actcttcatg gattgcggag 2753281 agatccgcag cactacggcc gttttcgtcc ctttctgatc ttcaccgcaa aatgactggc 2753341 attgtaaaag ctgcggatcg cgagacacag cttgatttaa tcaaaaagca tccccggctc 2753401 ggaacaaaga aaacaatgag cgatgactcg gtacgagagc agcagaacgc agggctcggc 2753461 aaattagaac agcaggaata cgaggagttt ctcatgctga atgaacacta ttatgatcgc 2753521 ttcggctttc cttttatttt agcggtgaag ggaaagacga aacaggacat tcaccaagcc 2753581 ctgctggcaa ggcttgagag cgaacgagaa acggagttcc agcaggccct tatagaaatt 2753641 taccgaatcg cccgctttcg tctggctgac atcatcactg aaaaaggaga gacgcaaatg 2753701 aaaagaacca tgtcttatgg caaaggaaat gtatttgcat accgaacgta tttaaaaccg 2753761 ctcactggag tgaagcaaat cccggaatca tcttttgccg gaagagataa taccgttgtc 2753821 ggcgttgatg tgacatgcga aattggcgga gaagccttcc tgccatcatt tacagacgga 2753881 gacaacactc tcgtcgtggc aacggattca atgaaaaact ttatccagcg ccatctcgca 2753941 tcctatgaag gaacgacaac cgaggggttc ctacactatg tagctcaccg atttttagat 2754001 acctattctc atatggacac gatcactctg actggcgaag acattccgtt tgaagcaatg 2754061 cctgcatacg aggagaaaga gctcagcaca agccgcctcg tcttcagaag atcgcgtaat 2754121 gaacgaagcc gctctgtgct gaaagcagaa cgaagcggga ataccataac gattacagag 2754181 caatacagcg aaatcatgga tcttcagctc gtcaaggtga gcggcaactc cttcgtcggc 2754241 ttcatccggg acgaatatac gactctcccg gaagacggca accgcccgct gtttgtctat 2754301 ttaaacatca gctggcaata tgaaaataca aatgactcat acgcttctga tccagcacgc 2754361 tacgttgcgg ctgaacaagt ccgcgactta gcgagcaccg tttttcacga gctcgaaacc 2754421 ccttcaatcc aaaacctaat ctatcatatc ggctgcagaa tattagcgag gttcccgcag 2754481 ctcactgatg tcagcttcca atctcaaaat cacacgtggg atacggttgt cgaagaaatc 2754541 ccgggctcaa aaggaaaagt ctacaccgaa ccgcgcccgc catacggttt ccaacatttt 2754601 accgtgacaa gagaagacgc cgagaaagaa aaacagaaag ccgctgaaaa atgtcggagc 2754661 ctgaaagcct gatgggaaaa ctgacaaccc atattttaga tttaacctgc ggcaaaccag 2754721 cggcgaacgt aaaaattgga ttgaagcggc tgggcgaaag tattatgaaa gaggtataca 2754781 ctaacaatga cggcagggtc gatgtccctc tgctggctgg tgaagagctg atgtcaggag 2754841 agtatgtgat ggaatttcat gcaggagact attttgcgag taaaaacatg aacgcagccg 2754901 atcagccgtt tttaaccatc gtcaccgtcc gttttcagct agcagatcca gatgcacatt 2754961 atcatatccc gctcttgctg tcgccgtttg gttatcaggt gtataggggg agttaagaag 2755021 gaagcccgcc tcaccggcgg gcttcttttt gcacttcaat taacttttga tcctaggaca 2755081 gtacttgaag tgatccccac acttagtgaa acaacagcta gaataaacat tcacctatat 2755141 ttttcaggat aattgcctac gagaaaaata ccctgtagtc ctttcattta taaatcgagg 2755201 tttcaaacta ataagtcagc tcttagcagc cgagctccct tctccaatcc tataaacaga 2755261 ccgcgttttt tctcgaaaaa atactctgaa gacaattgct gcgtttttaa tagttttgat 2755321 aacgcgttct ctcttacacc tttagacaaa atattcattt tttctttttt agacttaaat 2755381 ctatgtcgaa aataatcgtt ggcatatctt atcctatctc cactaaagga ggtgacatta 2755441 tgggattcta caattctggt ggatacagtg gaaactctgg ttactcaaac ggtttcggga 2755501 gctccttcgc tttgatcgtg gtgctattca ttttgttgat cattgttgga gcagctatct 2755561 ttaattatta agtttaactt tccttgcctc cgccgtatcc aacacctccc tgtccgacag 2755621 acgccataag aagtttttat ggcgtctttg ctatgtgttc actaatcttt ttgtaatcca 2755681 gaagctgtca agttctacga gatttatcgt gtgttttccc acaacgcttc tgcgtcttga 2755741 tcgcgctgtc tgactgaggc taaaaaagtc cggcttttaa aagccggact cccgtctacc 2755801 cccgttcaac tctcttctaa tcctgcaagc tgaccgcata atcccgccat acccggtaca 2755861 ccggcacaaa ttccccgcca gcccttcttc tatatctttg tcagaaggtt gaggggtttc 2755921 ccgaaacaat gctttaagcg caatgatcat tcccggcgta cagtagccgc attggaagcc 2755981 gccttcttcc aggaaagcgg tttgacacat atccagctct tctttttgaa gcccctcgat 2756041 ggttgtgatg gaatggccgt ctgcttgata ggccatcgtc atgcacgcat tggccagttt 2756101 tccgtcgatt aaaatagagc aggctccgca gcggccgatt ccgcaggaca cctttgtccc 2756161 ggtcagctga aattcctttc taagcaggtc actcagatgt gtcgtaggaa cggcagcaac 2756221 ctcccacgcc tgaccattca cggtcatccg gaactgttcc ttttttacag gaaatggccc 2756281 ggcctctttt atgtccattg cttcagcccc tttctgtcga tcgcttcaag caactcttct 2756341 cttgaaattg gcagcttgtt tatccagcat ccgaccgcat catgtactgc ctttacaatc 2756401 gccggagtga tggcgattgt tccgatttca ccaacaccgc gcggtccata tacgtctccc 2756461 ttcattaagt cttctattgc aatcagcttc atgtcaggaa catctttgat tccgggaatc 2756521 aaatagtgat cgagattttc cgcagcataa cggccatccg tcattttcgc ttcctccatc 2756581 agtgtgtagc cgagtgccat ggcagcgccg ccttcaattt gacctcgata tccctgcgga 2756641 ctgacaaccg gacctgccgc aatagcgtgc tcacaatcta tcaatttgac atcgcctgtt 2756701 aacagatcta cctccacctc aacggcagcc gctccaaatg agtagaggaa atggccgccc 2756761 accacaggat caggcgttgt tggaaagtca aaggccgttt cctctgccaa agggcctttt 2756821 tcagccagct ccttatacgt caccacgagc gcctttgtgt ttttgtcacg caagcctgca 2756881 gcgccgggaa taagattttc cgctgaacag ccgctccatt ctgccgcccg ttttttcaac 2756941 tgagctagaa acggcttctt caaacgctgg atcgcgtgcc acaccatgct tgtgccgcgg 2757001 gatgctgtgg aggagcctga cttcggcact tttgcggtat ccccaataac aatggaaata 2757061 tcctctgcgg cacaacccag ctcctccatg acaatctgtt caatcgctgc tagaatcccc 2757121 tgtccgcatt cttcaaatcc aaacgaagca gtgattttgc cttcactcga aagagacaaa 2757181 cggcctcctg ccgcatccat tcggccaaac cccagcccgc cgccgtgcat tgtaattgcc 2757241 gctcccgtgc ctctttgcag atacccgcag ttccggcttg tttttttaag aatgggagat 2757301 ttagatatgg cattcaacac ctgtgccgct ccgtcagttg gtgcaattcg atgctcaagc 2757361 ggccccaagt catgcggttt tctgatattt tttcttctca gctcgagcgg gtcgatgcca 2757421 agcatgccgc tgagacgatc gagatgggtt tcgagtgcaa atgtgatttg gttgccgcca 2757481 aagccccgaa attcccccgc caccccgttg ttcgtaaata ctgatattcc ttcagtccgg 2757541 atattcggaa tacggtacgg ccccgcggca tgctcgacag aaaaatcaag aacagccggt 2757601 ccgagcgtag cgtaagcgcc tgtgtccgcc acaattttca cgtcgtgcgc caatagattt 2757661 cccgaatgat ctgcacccgt ttttatcgta atcttcatcg gatggcgctt aatgccagaa 2757721 cgtacagatt cctttcgtgt ctgatgaatt ttgacagggc gtccgctttt cagggccaaa 2757781 agcgcagcat acggctgaat attcagctca tccttccctc cgaacgagcc gcccatcgga 2757841 cttgacacaa ttctgatctt ctcttcagga atatcaaaaa tacgggcaag ctggaaacgg 2757901 tctttatagc cgtgctgggt tcctgcatac atcgtaaaac ccccgtcgtc ttccggaacg 2757961 gctacacctc cctccgtttc catatacgta tgcatctgcc gcggcagctc ataggtttct 2758021 tcaaagactg tgtcagatgc ttgaaaccct tcttccacat caccgtttga aaaaaatgcg 2758081 cggtgcagga tattcccgtc ctcatgcagt ctttgcgcat tcggccgaag cgctttttct 2758141 ggtgaatcca tgacttccag ctctttatac tcaacttgaa tcagctccag cgccgcttcc 2758201 gcgatttctt ccgtttccgc agcaactgcg gcgatcgcat ccccgacata ccgcaccctg 2758261 tcctcacata aaaccggctg atcagggatg acaatgccaa atcggtttaa gccgggaacg 2758321 tctttatgtg tgacgacggc ctgcacgcct tccattttct cagcttttat ggtgcaaacc 2758381 gacacaatct ctgcatgagg ataagcactt ctcagcacct tgccatacag cattcctgga 2758441 aagctgagat cggtcatata tttcaattcc cctgtgacct taccccttcc atccggcctg 2758501 actcttgacg gtttgttgat gatcatttat tcccctccct cagccatcag ctctgccatg 2758561 atgacgttgg cagcggcttt ttttctgtat gccgctgaca taaaaacatc tgaggaaaac 2758621 ggcagctcat ggataagtgt tttgtacagc tcatgcgggt cccaccctgg tgccatccat 2758681 ttcgcttcgc tgtccaataa tctcctagga gtgatatcgg catggccagc ggcgaggcga 2758741 atgctgccgt ctttcaaaaa acgtccagct gcaacagcag ccgctccggt aaaagcctgg 2758801 cgccttccaa gcttgtgata aaatacacgc tctccctccg cccgcgggat gatgacacgc 2758861 gtgacgatag ccgttctaaa gtcttcctca ctgagccaag cgccaagcgg cagcctgatt 2758921 agctcctttt gatatacgat aagctcagca ccaagcacaa gcagaagcgg aatgaaatca 2758981 ccgattttac tcgctatgtt gccgccaatc gtggcacggc tgcgaatccc cggtgcagcg 2759041 acagcggaag cagcgtcact gaaacagcta agcgctctct taatcaaagg gttctttctg 2759101 cattcattca gtgatgtgag ccccccgatc gacacgtggg tgtcactggt gctgatccct 2759161 cgcatttcgt caatcccttc aaggctgaca aggtgctgtt tcggtagagt tcctttgtcc 2759221 cactgaagct gaaggagcgt gcttcccgat gcggcacaca catccggagc aagcttctct 2759281 aaaagcgaat aggcctcatc aagcgctgcc ggtctccata attgaatatt catccttgct 2759341 tttgtcactt ggccgttcaa gacatcgccc tccttaccat gtcatattcc tcgggtgtat 2759401 caatatcgtc caactcaccg ctatcctttg cctccaaaac cgctcctgct ccaagctgtc 2759461 cgcttttcag gagcctgcga gccccttcat ctccctttaa tccctttaca taaggaaaac 2759521 atgtcgacga gaagtagatt ggcggggtga acgcccctaa aaacgatgac acggcaaatg 2759581 actcaggagc cagagccaca agggcattga gatgatcgac ggaaagctga ggctggtcgg 2759641 ctaacaaaat gacaatgccg tccgccccca tgctttctgc ttttctcacc ccgctgctga 2759701 ctgaatgccc ctgacccttt tctgcgtctt ggcaaacgtg caggctccag cgtttttgaa 2759761 aaggcggagc gtgatacggc gctcctatcc actcaaggga ggcatgttct gtccgctcga 2759821 cgaccagcac gtgatcaagg cgggacgaca gagcagtttt caaggaaagt gagcctatgt 2759881 tttctccttt tagcggcaaa gccagcttgt tttgtcccat tcttctgctt ttgccggcag 2759941 cgagaaacac gccgatcaga taggggcttc tcatacaacc gccacccgtt ttcttgtttg 2760001 aatgatttct gcaactacac ttaccgcaat ttcctcggga ccttccgcac cgattttcag 2760061 cccgaccgga ctgtaaaagt gagacggagg atgttttccg ctcagcagcc gtttcgtgcg 2760121 gtttgccgaa cccaacagtc caatataatg gaggttttga gaaaataaga agttgatgat 2760181 cgtttgatcg tgctgataat gatgggttgc cacaacagct gcatcatgcg gaaaaaattg 2760241 aaattcgcta agcatttgtt ccggaaaagc ggtgatcagc tgatccgctt ttggaaaaag 2760301 agaggatgta caataagcgg gccgccaatc cgtcacgata acagaaaacc ctgtgtcagc 2760361 cgccaaattg gccagcggta cattatccgg tcccgcccca aacagaatga gacgcggctt 2760421 cggttcaatt cgctgaataa acatgttagt ggtttgatcg aaatgcggta aatgaagcgt 2760481 tgaaacagta cgttgaatat cttgcagagg cgcgtccggc cagttcccaa aatgtccgtt 2760541 ctccgtcaga aataaataat gggaggattc aatctttata acggaagtga cagctttgcc 2760601 tgaatgaagg cagtccctca ctttctcata gtgccgcctt ttttcctgag tgattcgctc 2760661 tgcatgaaca tgaataatgc cattgcaccc ggctcccatg ccccaagaaa gatcgtcctc 2760721 cgaccgcatg tcgtagggaa tcagcgttga tgtgagctga tcgcccagcg cactgattct 2760781 ttggaataca tcttcttcca cacacccgcc gctcagcaag ccaatccgtc tgcctttttt 2760841 cttaaagagc atagaggcgc ctgcttttcg atacgcggag ccttcaactt gaacaattgt 2760901 cgccagtaca gcctcctcct ggtcttccag gagcgcatct aacatcgtgt gaaaattccc 2760961 caatgccgca tcctcctctc gaaaattgcc gtgagaaaca actagttcag cgtgatttta 2761021 taggtaactt gtataaagaa tagacgatgg aagaaaaaat gactcatgat ttgtcagaaa 2761081 atgaaacaca tagaaagagg atttgtaaaa agagtcaaac gaagaaaatc agattggaga 2761141 aaacacgaaa tcatatcgtt aaaaagcttg cggagttccg caagcttttc tttacaccgc 2761201 tgcctggcgg ccagcgtttt catacacatc cagcgctgct tggagcgctt ttcctgcttc 2761261 gattcctgcg ttatgtctga gaagcacagc ctctaacccg gcaagcacga atagcacgtt 2761321 ttcttttctg cagctgtacc ccatcgtgcc gatcctccag atcttccctg caagcgggcc 2761381 gaatgagctg gcgatttcaa tgccgaattg tgccagcagc atgtcacgga cagactcgcc 2761441 gtcaatgccg ccgggaattt cgacacaggt gacaacaggc attttgcagc tgtcatctcc 2761501 aaacaatctt agccccattg cctttatccc tgctgctaat gcggcttcat ggtgccgatg 2761561 ccgctcgaaa cgcgtctcaa gaccttcttc aagcaccagt ctgactccct cacgtaaggc 2761621 gtacagcatc gtcgtcgctt ctgtatgatg attgagccgt ctttcgctcc aataatcctc 2761681 aagctggctc aaatcaaagt agttgcttgt aattggccga tttcccgaaa gtgctgccct 2761741 gtcagcttgt gtcgcaatcc cgcgttccac ctttttgcga gctgcaatca cgtccgccac 2761801 ccgctcatta tatgtaatcg gcgccattcc tgaaggcaca gacaaacatt tttgcgttcc 2761861 gccgatggca gcgtcaatct tccattcatc gactttaacc tcgcagcccc caatcgttgc 2761921 gactgcatcg acgataaaca atgcatcctc ggtgcggcag gcttcgccga tggctttcag 2761981 cgggtgaatc cgtcctgtcg atgtttctcc atgcaccatg gccacaattt tcggcttcac 2762041 tttttttatc tcccgtatga tgtcctccgg gtcaaaaacc gttccccatt cgcactccag 2762101 catatgaaca tttgccccat atcgctcggc gatttcagtc agcaaataac cgaaacggcc 2762161 gtaaatggga atgagcacat catcttccgg ctctatcaca ctagccagca ctgcttcaat 2762221 tcccgcccgt gaagtgccgt caatcgggta tgcccagcgg ttttttgttt ggaacagctc 2762281 ccgaagcatc tccatcgttt cattcataat acctgtaaac gccggatcaa attggccgac 2762341 aaccggggtg ctcattactc ttaatacacg cggatcaacc tcaacaggcc ccggtgtcat 2762401 aatcgttctt aacggggtgc ataattctct tctgcctgac acagccattc ctcctttatc 2762461 agtaagccag tttgtataat aaatcagtca gtgcgcggac gccgatctca agctgtctgg 2762521 ctgacgtata ttccttcggt gagtggctga cgccgcctcg gctcggcaca aacagcatac 2762581 aagcaggata gcgccttccg atcatttgcg cgtcatgccc tgctccgctc accatttcct 2762641 cacagctgaa gccgttttct aatgctgttt caaaagccgc agccttcagc ctttcgtcca 2762701 tcggcacagg ctctatccgc atatattcat caatcacagc gcgaattcct ttttgtaggc 2762761 aaatgccgtt gatcaaagca accatgtctt gatgaaactg ttccagcaca tgctgatgct 2762821 gatggcgaat atcgattgaa aactggacgc ggcccggtat gacattggct acattgggct 2762881 ctgccgttat ttttccgcat gtcagacgga gctcatccgg cagctcatcc gaccgcagca 2762941 gcagctcatg aatgatacgg ctgctggctg cgagcgggtc cttgcgccat ttcatggagg 2763001 tggttcctgc gtgattgcat tctccttcga gcgtgacgag atatcgtctc tgccccgcaa 2763061 tacttgtcac gatgccgaga tcccggcctg acatttccaa cgtcttcccc tgttcaatat 2763121 gcagctcaac aaacgcgctg atatctgtcc tatatgctga ctgaaacaca cctttgccaa 2763181 aaccgctctc atgcatcgct gtttggaggg agactcccga ctcgtctctt ggctcttttg 2763241 catcttgttc tgaaaaaaca cccgtcatat tccccgaccc ccaataggtc attggaaaac 2763301 ggctgccttc ctcctcacat aaggagaccg cctcgagcgt tttttttggc gctccgtatg 2763361 tttccttgag ctgctttaac gcgagcattg ccgccagaac gccataggcg ccgtcgtatt 2763421 ttcctccatt gatgacagta tcgatatgtg aaccggttac aatgacttca tccggagact 2763481 gggtgcccga aagccttcca aacacattgc cgacatcgtc gaatcttgtt tcaagcccga 2763541 aagaagacat ttccgttttc acagcaagct gtgcgtccat ccactctttt gtgtataaaa 2763601 gcctcgttac gccgccatcc gcagacgcac cgtattgggc gagccattca atataatctg 2763661 tgatgctgtt ttttactgaa agcttctgct tttccatgta ctcccccctc tggccgctat 2763721 ggtgacttca ttatagaagg agcaacatga tagttcattg acagattaac caaaaaaacg 2763781 tttatttttt agccacagta tccatccagc aaccagatac accctacatg tcacaactat 2763841 tttgatgtaa aggtcaaaag aaaacacggt aaggaagaga gccagcaaga gcgaaagaga 2763901 gggtcaaaat gcctttcata tgaacaagct aagctggaga ggcgatgttc gcggaacgga 2763961 tgaaaacaga aatgccggca gcccgcaaaa acaggaccta aagatatgga aacaggagat 2764021 ttccgcctcc tccaaaggga ctaatttaca attttaatga aaaatataca aaatgacact 2764081 tctatccttt atttcaattt tagataatag atatgatctg ataaaaggag ggcaagtgat 2764141 gacaaaaaaa gcatggtttc tgccgctcgt ctgtgtatta ctgatttccg gatggcttgc 2764201 gccagcagct tcagcaagcg cgcaaaccac attaagcctt aatgaccgat tggcgtcttc 2764261 cccttcagga acgggaagcc ttctctcatt agccgccccc gctgcaccct atgctgacac 2764321 agatacctat tatgaagggg ctgaaggtaa aacaggagac tcgctaaaaa gcaccctgca 2764381 ccgtattatc agcggacaca cgatgctgtc ctacagcgaa gtgtggaacg cgctgaaaga 2764441 aacggatgaa gacccaagaa atccgaataa cgtcatcctg ctctatacga atgaatcgcg 2764501 ttccaaaaac ctgaacggcg gcaatgtcgg cgattggaac cgcgagcatg tctgggcgaa 2764561 atcccatggc gattttggta cgagcaaggg acctggtact gatattcatc atttgcgccc 2764621 ggctgatgtt caagttaaca gcgccagagg aaatatggat tttgacaatg gcggcactga 2764681 atatgcgaag gcacccggaa attattatga cggcgattca tgggagcccc gcgatgatgt 2764741 gaaaggcgat gttgcccgca tgctgtttta catggctgtc cgttacgagg gtgatgacgg 2764801 ctatcctgat cttgagctta atgataagac aggcaacggc tcagctcctt atcatggcaa 2764861 acaatctgtc ctgctcgaat ggaataagca ggatccggtt gacgaccgcg agcggaaaag 2764921 aaatgaaatc atttatgaaa aatatcagca caaccgcaat ccatttatcg accaccctga 2764981 atgggcggat gagatttggc cgtaagaaaa aggtgctcct tttgaggagc acctttttct 2765041 aatacacagc ctcttccgtt tccgcatcga aaaagacgac gtggtccatt ttcactgaga 2765101 gctggattga atcgcctgca tcgattcgcg tgtttccgtc caggcggacc ttgagccgct 2765161 cgtccccagc catgacatgc actatgagct ccgagcccag attttcattc acttccacgt 2765221 tcgcttgaaa cactgaatca aacaactggt catttcctgt catttgtgtg atgtgctccg 2765281 gccgtacacc ggcaatcatc tgttctccgg catatccctt ttccttcagc cgctttgctt 2765341 tttcttcagg aatatgaagc cggatcgaag aatttgtgaa aaacagctcg ccatgctgct 2765401 gttctatgat gcctttcaaa aagttcattc cgggagagcc aatgaagcct gcgacaaaca 2765461 aattggccgg gtaatgataa atgtcatgag gtttcgccac ttgctgaatt tccccttcat 2765521 tcatgacgac aatccgatct cccattgtca ttgcttcggt ctggtcatgc gtgacataaa 2765581 tgatcgttgc ctctaatcgc tggtgcagct tgctgatttc tgtccgcatc gtcactctta 2765641 gttttgcatc cagattagaa agcggctcgt ccattaaaaa gaccttcggc tccctcacaa 2765701 tcgacctgcc aagcgccacc ctttgccgct gcccgccgga gagcgccttc ggttttctct 2765761 tcagcaaatg ttcaatttct aaaattctgg ctgccgcatg aacccgctcg gcaatttcct 2765821 gtttcgccat ctttctgagc tttaatccaa acgccatatt atcaaaaacc gtcatatgcg 2765881 gataaagcgc atagttctgg aataccatcg caatatcacg ttctttcggc ggaagatcat 2765941 tgacccgctc cccatcaata agaagatttc cttcagaaat gctttctaat ccagccacca 2766001 tccgcagcgt tgttgatttt ccgcatcctg acggccccac cagcaccaaa agctccttat 2766061 cctttacatc taaatcaaag tccttcacgg ttaattgtga gtgatatgat tttttgacgt 2766121 gttcaaatgt taatgaagcc atcagaaaag tccccctatc ttttgacccg ttatttcgtc 2766181 actggaaaca acttggtctt tctgttattt ttagagtaat cgattcccat ttttgctata 2766241 tttctaaaat aaaaaatgta aatttgtatt ataacgtcat aatacattat aatataaata 2766301 ataggttaaa aggaggctac cctttgttaa acaacggaag ttctacacct ttatacattc 2766361 agctaaaaca aatcatcact gatgacatca aaaagggcgt gtattcccca accgccaagc 2766421 tgcctaccga aaacgagctt tgcaccaagt ataacgtcag ccgcatcacc gtcaggaaag 2766481 ccattctcga tttagtcgaa gaaggctatc tgatcaggca gcagggaaag ggaacgttcg 2766541 ttaaaagccc taaattaaaa cgagagctga tcgctgtaaa cggctactcg gaatttatgg 2766601 aatcaaccgg caaaaaaccg aagcatcatg tgctgtccca tgacatcatt ccagcgtcaa 2766661 aacccatcgc cgaaaagctt caaatccaac ccgagagccc tgtggttgaa ttaaaacgga 2766721 ttttatataa tgatgatcag cctctcacct ttgaagtgac gcattatccg cttgatttgt 2766781 ttcccggcat tgataccttt attgctgacg gcgtctccat gcatgatatt ttgaaacagc 2766841 aatacaaagt tgtacccacg cacaatacga agctattaaa cgttgtatat gcccaacagg 2766901 aggaaagcaa atacctggat tgtgatatcg gggatgcgct gtttgaaatt gataaaacgg 2766961 cttttacatc aaacgaccag ccaatctatt gctcattgtt tttgatgcac acaaaccgtg 2767021 tcacttttac catcaacagc ccctacacat aacaggcata aaaaacgaga cactgcttat 2767081 agtattctcg ttttttcact gcttcccccg tcctccaagc gataaggata gccatagccg 2767141 aaagctccgt acacaccgca agttttcgca gccgtttcag cagcctggcg caaagcatac 2767201 gttatatcct gcttcacgca aaaggcagtc aaaaagcctg ctataaaaga atctcccgct 2767261 ccaagtgtat ctattatatc agcttccaca atcggctgat gatagactcg atcacccgca 2767321 gacaggattg ctccttggcc ccctcgggtc atacaaacca ttttggctcc gtacccatga 2767381 gctgttttgg caagctcacc gcattccgac tcactcaaat cgcttcctga aaaaaacgca 2767441 tacgtcacat aaggacagac cctcctcaaa taatcatcct cccgattggt tgaaaaatca 2767501 aatgagaccg ggaccagccc gcacagctgc ggaagatcgt tctcaagcct gctgtacacg 2767561 ctcgtatgca gcagatcatg cccgctgata aaagatacat ctttctcctg aaacgcgagg 2767621 cgaagccggg actgaatgcc gcctttattt gatctgacaa aaatgcggtc cccctgttca 2767681 tcaagggtga caatcgccat cccgttttct ccgtgcgcct ggcggatata atctgcattg 2767741 acctgctcca gcttgagaac gttcaacaga tgcgccgcgg cttcgtcatt gccgacgatt 2767801 ccgatatagg aagactcatg cccgagccgc ttggcaagca cagcaacgtt taaggcattt 2767861 cctcccgggt aaaatgtttc ttgatcctgg tagtaatcta caacattatc tccaaccgca 2767921 atcaatttca tagcgcttcc tcctttatcc ttttacactg ccgcttgcaa tcccgcggac 2767981 aaaatatttc tgcatcaata aaaatagaat aataatcggc gcggctgaaa tcgttaaccc 2768041 cgccagcagg acgccccagt ctgtctgcag cgcgtctctg aactgcatca gcccggctgg 2768101 aatggtccgt aaattctcat catctatgaa aataatcgca aacataaact cattccatgt 2768161 atggtaagcc gtcaaaatgc cggatgtcac caaaatcggc acgctcattg gtaagaaaat 2768221 tctgaaaaat actccaaaac ttgtacaccc atccaaatag gccgcctcct ccaattcttt 2768281 tgaaatagaa agaaaataag agcggatcaa aatgatggtg aatgggatcc gataagccgc 2768341 atacggcaag attaacgccc aatacgtatt gtacaggccc agcgactgaa taatagaata 2768401 aagcggcaca agactgacct gcggcgtcag catcaatccg ccaagacata gcaccaaaaa 2768461 gaatcctttt cctttaaact caaaccggga aaggccatac gctgcccatg cactgataaa 2768521 gacagtgatc acacacgtca gcgccgtaac gatgacactg ttcataaaat aagaagaaat 2768581 cccctgattc caggcggaaa caaaattttc cggatgccac gaagacggca gcgaccagct 2768641 gtgctcaaaa atatcgtcag agtttttaaa ggcgctcatc accatccaga gaagcggata 2768701 ggcaatcgca atcagataaa gaaacagaaa aacccacaca gacgtttctc cgatatacca 2768761 ttttcgtcta ggcttatctt tcacctcaat gtgctggtca ggcaccggct ccaatctgaa 2768821 cgaatctgtc ttcttctgag gcagcatcag ttactcctcc tttccggttt taaagaactt 2768881 catttgcatg agcgataatg caagcgtaat gattaacacg acagtggcaa tcgctgaggc 2768941 gtagcccatc atatcctttg taaaggcgct tttatataaa aacgtgctca agacttctga 2769001 cgcttttccc ggcccgccgc ctgtcaaaat gtacggctca ttaaagaccg taaaggctcc 2769061 ggtcagcgtc atgaccaccg caacaaaaga catctctttc gtctggggaa cagtaatatg 2769121 aaaaaactgc tgaattttac ccgcgccgtc aagccgggcc gcttcataca gttcatccgg 2769181 tattttttga atcgacacga tgtacagcat cgcaatataa ccgacagatt gccactggga 2769241 cacaaaaatg acagaaagca tagctgtgct gtcatccccg agccaggccc tcgtcagctg 2769301 atcaagaccg atggcctgaa gcagctgatt caaaagccct gtctccggat tgtaaataaa 2769361 atcaaacaaa agcgcgatca ccgtcattga gatgacaacc ggcaaaaaga aaacggtacg 2769421 aaaaaacggc gaccattttc tgaccagctt atcctcaagc accgccgcca aaatcaaacc 2769481 gccaaatacc tggcatacaa ttgagatcac tgcataaagc acattattgg taagtgcctg 2769541 atagaagaca ggatcatgaa ataattcaac atagtttttt aagccgataa acgttttttc 2769601 cggagaaaat gagctccact gaaacaggct gaggaataca ttctcaaaaa tcgggatata 2769661 aacgaaaagt aaaaaaacga gagcgggcac caaaaacaaa taggggatta ttttattctg 2769721 attgaccaag ggtatctcat ctcctttata aaaagaaaag gtgcgaagct tcaccttttc 2769781 tttgatttat tcagctgacg ccctcacctg ctttgctgcc ttttgaacgg ctttcatcac 2769841 ctgctgcggt gtcatgtcgc cgccaagcat ttgctggacg cccgttaggt acgcatctgc 2769901 gacttcaaca tcgacatcca tatcaaacca tggaaccatt gatttggcat caacaatatg 2769961 ctgaacggct tcacgctgaa tggctgttgc attttcttca gtagccgtac cttgcactgc 2770021 actgtatttc ccgacatctt tcacgagctt ttcgcccatt cttttcgacg tcaagaactg 2770081 caaaaattcc atcgcttcct tcggatgttt tgttcttgag gagatcatga atccttccgg 2770141 cgctcccgtt aacgcttctg aagatccttt ctgcccgctg atttcaggaa atgggaacat 2770201 cccgagatta accggttcaa ccagcttgat ttccgctgtt tccgcatata tcatcgccga 2770261 ctttccgctc ttaaattgct gtctcacata ttcgtggtcg acggagttta catgtttatt 2770321 aaagtaaggc atcagctctt gaagcttttc aagtgctttt acgtagcctt catcagtaaa 2770381 ttcacccgtt ttggcgttat agtccttttc ccgtgttttt tcatcgacca tccgctgatt 2770441 aagcgtgccg atatagtgcg agattgtcca agtcgccttt gttccaaagc tgatcggtgt 2770501 gtagccatgt tctttcagct tttttgacac atcgattaat tcatcccacg tcttcggggg 2770561 atcaagattc agcttttgga aaatgtcttt attatagaag aatgatttag cgtccatttg 2770621 ccacggtacg ccatattgct tgttttcata agtaaatggt gtaatttgcg attgaacgag 2770681 ctgtgatgac caatcggtgt catttttgta gtaggacgag agatcaagtg ctttattgcc 2770741 tctgataaat ttaaaagcaa actcatcgct ccaagagaag taaatgtcag gagggctggt 2770801 ggttcccagc atgaccttaa ttttatcttt ataggagtca tttaaaacgg cttcaatttg 2770861 aatgtcgata tctgggtgat ctttttcaaa ttccttaaca acctcttcaa aataactttt 2770921 ttccggctcc tttggccatc tgtggaaaaa tttcaatgtc acctttccgt ccgctgaact 2770981 gctttggctc gaacagcctg cgatggtgag catactgaca gctgcaatga tcaagaacaa 2771041 caacattttc ttcaaagggt tggcctcctc tggacattag actataatgt tatataacat 2771101 tatagtctaa tgcataatgg ttcttcattt tcagatcaat actcaacttt ccacatgtat 2771161 cttctatgag ataaaggatg atttctctcc tctgccagct cgtctgcata gcttctcagc 2771221 acacgattga gaacgagcgg agcaagatag cctttaactg aatcgtcaat tgcagtgaag 2771281 tcgtaagatg cagcatcaag cacagtgagc tttttgccat actttttcga gaaggtaagc 2771341 gcccgctctt caagaggtct tgtttcatct aaaccgagca ggatgataaa cggcacggat 2771401 tcatcaataa tttcaaacgg tccgtgaaaa tattctccgg catgaatggc gtgggaatga 2771461 atccattgca tttccatgag aatgcagatg ctgtaggagt aagcgacacc gtagtttgca 2771521 ccgcttgcca tggtataaat aatgctttct ttttcatggg cttttgcaaa ttgcttggcg 2771581 ttgtcagctt cctgcttaag ggctttttca tatacagcct gcaattgatc taagccttca 2771641 attgcttgct caaatttcgt attgttttct aatacttgca gggttccaaa aacgatttga 2771701 tacaaaacgc catagtttgt attgatcgca agcgcctcat caccccaatc gtactgggca 2771761 acatattgcg cttcctgcgc taaaggagac tccggtttaa acgtcatcgc aatcgtaagt 2771821 gcgcccttgc cccttgcaaa cgcagcagct ttgactgtct ccggggtatt tcccgaatgc 2771881 gagcacaaaa taacaagaga cttttcacca agctgaacag ggttgcgctg aataaattcg 2771941 ttggcgctgt agagatcgga gtttattgat tttgactctc tgtcaaacac atacttactc 2772001 ggatacataa tggcagaaga ccctccgcat gcgacaaaga atacatgatc aatggttttc 2772061 cctttcaaat cctgcaagaa agcttgaacc tcacgattta cttttgctgt ggcctgactc 2772121 aaatccttca ctcctcgttt ttattatata acgttatata acattatata ttgttatatt 2772181 aaagtccgcg ggtaggattg tcaatattat tttctgaaat ttctcaataa tttattcgga 2772241 tgacagacaa agggtctata tgcgaaaaaa tgcccaaatc aaaagccaga acttgactta 2772301 agctctggct tcgctgttca atccgcagac tgacgtctta tttaaaaaat accttgtcta 2772361 tattgtactt cgagtgctgt gtattgatga tatatgtttc gtaaatctct ctttccattg 2772421 gatcatcaac tacacatacc tcaattttat aaacttcatc tctgtgatgt ttgatcggtg 2772481 aaacagtgtc ttcgaaatgc ttcttaattc tctgtcttaa ctttctggct ttaccgacaa 2772541 acagcagctc gtcatgaatg ttgtaaaaca taaaaatgcc gcctttgtcc cttgggatct 2772601 ggtgaaagtc gatgaatccg tgaatcggtt ttatcttcgg ctcgttatca ttagctgact 2772661 gctgtcgttc agtgatggtg acattcggtg cgggtatatc aatttttatc aaaatcagtt 2772721 cacgtcctct ttttcattaa agataaatgc taacacatac agaaaagaaa agctagaaca 2772781 gctttattat atttgtttgt catgctctta cttattatgc aagtgctccg gctggatcat 2772841 aaggactaag gtctaattct gtctgctttc cgagaactag ctttgcgagc tctgcaccca 2772901 aaaacggccc catcgtcagt ccagaagcac ccaaaccgtt tgcagcgtac aggccttgaa 2772961 cattcggcac ggcccctacg accggcagaa atcccggtgt aaacggcctg aagcccactc 2773021 ttgtttcaac agcagccgca tcagcaagac ccggtgcaac ggctaacgct ttgctcaata 2773081 cttcgtgctg gcctccggct gtcacacgaa gatcatcaag accggcatcg ttttcgtgtg 2773141 tggcgccggc tacaattctg ccgttatcaa acgacagaat gtactgatca ctcggcggca 2773201 ttacaaccgg ccacgatcct gtatctgcat ctgtcatttc aaaatgcata atctgcgctt 2773261 tttgaaatga cacttgaaaa tgaatgccaa gaggcttcaa tatctcattg gcccatgctc 2773321 ccgccgtcac aatgaccgcg tcagccgcaa actgctttgt atctgtttgc acgccggtga 2773381 ctgttccgtt ttcaaaaagc aaggacgcat ttcctttgat gaccgttgcg ccgcgtttct 2773441 ctgcagcgct taaaagcgac cggcacagcg ctcttccgtt cacacgggcg gcaccgctga 2773501 tatgaaccga ttcatagccg tcagctaaaa tcggaaacag ctttttcgtt tcacttgcag 2773561 acaagcgggt aatgtcgccg atttccggcg catcctcccg tctcttatac gccctttcct 2773621 ccattttatc gagtttagac gcgtcagtat gaatgctgat ggcaccgaca cgtttgtatc 2773681 ctgtatccga ttcaccgtct ttttccaatt gatggattaa atccttatag taccgcgctc 2773741 cccccttagc aagctggtac caatcctgat tacggcgctg cgagagccaa ggacagacga 2773801 tccccgccgc cgcatcagtc gcttgtcccg gctctttccg atcaatgaca gtaacgcgag 2773861 cgcctgtttt tgcgagatga taagccgtcg acgcgcccag aatccctgcg ccgacgatga 2773921 tgtacgattt catatgcaaa caccttttct attataatgt ctattcattt taccaaatca 2773981 aatgctttcc ttcgaccttt tgccctaatg tggaaaaacc gcgaagttcg tccaatctct 2774041 ttactctcct atcgaatatc ctgtcactat caatagagaa aggatgatac catgagcgaa 2774101 aatcgtcatg aaaatgaaga aaacagacgc gatgcggcag tggcaaaagt ccaaaacagc 2774161 ggtaatgcaa aagtcgtggt cagcgtgaac acagatcagg atcaggcaca ggcgcagtca 2774221 caagacggag aagactaatg aacgaaaaca tcattcctct taacagacat actcaagaga 2774281 tacccactac tgaatctgtt atcaaaaaca gcggcaactc agaggtccat atcgacattc 2774341 acattgatac aatgccaatt gcttttgcta tattatgctc tgcattagcc gcaaagcaga 2774401 tgacaaaaga ggaattcgat atggcttata ctcaattgcg agagatgaac agagaaaata 2774461 acagcagatc atctgtaaag caaattatca atcaagagac agaagaagag taaaaaaccg 2774521 cggcccctcg gccagcggtt tttcttctgc atacaaaaag gacgcgactg aatcggttac 2774581 ttctgtacaa tttgaataag gttaccgcat gtatcgtcga agacagctat tgtgacttcg 2774641 cccatttttg tcggttccgt cgtaaacgtc acgccttttt cctttaatcg gttgtactct 2774701 ttttgaatat ctgcaacgcc aaacattgtg gccgggaggc cttcggagaa tatcttcttt 2774761 tgatactcct tggcggcagg atgttcattc ggttcgagta aaagctcggt tccgtcttga 2774821 tcatctggag aaacaagcgt tatccacctg aatttcccca tgggaacgtc ttcctttttt 2774881 ataaacccaa gtttttctgt ataaaactcc agtgccatgt cttgatcttg tacaaatata 2774941 ctggtaacaa cgattttcat actgtttttc cctccttcga tatgaatgaa gcatggtact 2775001 atgctaacaa tctggctaca agcaaaacaa cccacacatt tatcagaggc cctgttctga 2775061 ttttataaaa ttattctatc catcctttca gcaaattttt aagcggttcg ttgttgaata 2775121 taagtactcg atattttccc tttcgttttg atgttacgag tcctgcatcc tccagtacag 2775181 aaaggtgttt agctatcgcc tgtcgcgtaa tagaaaggtc gtactttgta ataagacgta 2775241 tcgtaagttc atacaacgtc agctcgttgc gttcagataa ttcgtctaat ataagccgcc 2775301 gagtcgaatc gccgagtgct ttgaatatag cgtctttgtt cccattcata tattgagtat 2775361 aagcaaccca ttagttgcat gtcaagtata agcaactgta tggttgcgtg atatagaaac 2775421 tgaacctatc cggcgcaggt ctgaaatatt ctaatcgata aggaattaaa accattaaaa 2775481 taacagtgga tatgtctctg aaaaataaaa gaagacgaac ttcaaaagtt cgtcttctac 2775541 aatcaaattc ggcacgccgg ccattttaaa gttgataact atctctaaac cccttgataa 2775601 acaaaggagt tttcatcatt aaccgataga accttccatt tcgaacttaa tcaaacggtt 2775661 catttcaact gcgtattcca tcggaagctc ttttgtgaat ggctcgataa agcccattac 2775721 gatcatttca gttgcttctt cttcagaaat accgcggctc atcaagtaga agagctgctc 2775781 ttcagatact ttagacactt tcgcttcgtg ctccaatgaa atgttatcat ttaagatttc 2775841 attgtaagga attgtgtcag aagttgattt gttatccata atgagcgtat cacactcgat 2775901 gttagagcgg gcgccttccg ctttgcgtcc gaagtggacg attccgcggt acgttacttt 2775961 tccgccctgt tttgaaatcg attttgatac gattgtagat gatgtgtttg gtgcaaggtg 2776021 aatcattttc gcacctgcat cctgatgctg gcctttaccc gcaagagcga tagaaagcgt 2776081 cataccgcgc gcgccttcgc cttttaggat acaagccgga tatttcattg tcagcttaga 2776141 accgatgttg ccgtcgatcc attccattgt tgcgttttct tcacagactg tacgctttgt 2776201 tacaaggttg taaacgttgt tcgcccagtt ttggatcgtt gtataacggc agtagccgcc 2776261 ttttttcacg atgatctcaa cgaccgcact gtgaagtgag tttgttgtgt aaacaggcgc 2776321 agtacagcct tcaacataat gaacgcttgc ttcttcgtca acaatgatca gtgtacgttc 2776381 gaactgaccc atgttctcag agttgatacg gaagtaagct tgtagcggtg tttcaacctt 2776441 cacgccttta ggcacgtaga tgaaagaacc gccggaccaa acagctgagt taagcgccgc 2776501 aaacttgtta tcagtcggcg ggattacttt tgcccagtgc tcacggaaaa tatcttcatt 2776561 ctctttcagc gcgctgtcag tgtctttaaa gacgatgcct tgtgcttcaa gatcttcttt 2776621 catgttgtgg tatacaacct cagattcgta ctgagcagaa acacccgcaa ggtatttttg 2776681 ttcagcttca ggaataccga gcttgtcgaa tgtttgttta atttcttcag gaacttcatc 2776741 ccaagaacgc tctgaacgct cagacggttt tacgtagtac gtaatttcgt caaagttcag 2776801 tgagtttaaa tctccgcccc attgaggcat cggcatattg tagaaatgct caagtgattt 2776861 caagcggaag tcaagcatcc attgaggctc ttctttcatg cgagaaattt cttctacgat 2776921 ttcttttgtc aatccgcgct ctgaacggaa aatggaaacg tccttgtcgt gaaaaccata 2776981 cttgtattca ccaatatcag gcattttttt agccatccat tttcactcca atccttttaa 2777041 ttgccgcctt cttctttcgc gactcctttt tcaagtgctt tccatgacag ggttgcacat 2777101 ttgatacggg cagggaattt tgaaacgcct tgaagggctt caatatcccc gagatctata 2777161 gaatcatcat actctttccc ttgcatcata tccgagaaaa tcttagacat ggaaagggca 2777221 gtttcaatat ctttcccttt aatcgcctga gtcatcatcg aagcggatgc cattgaaatg 2777281 gaacagcctt ccccttcaaa cttcgcatct tccacgatgt ctccgtcaag cttcattgtc 2777341 agtctgatgc ggtcgccgca tgtcggattg ttcatatcca cgacaatgct gtcatttaaa 2777401 acccctttat ttcgcgggtt tttgtaatga tccataatca cctgtctgta caatgtatct 2777461 aagtttgcat taaaagacat ttgtaaaata ctcctttgtc ttttgaagag cttccacaag 2777521 cttatcaatc tcttcctctg tattatacag ataaaagctt gctcttgcag tagcagttac 2777581 atccagccat ttcatcagcg gctgcgcaca atggtggccg gctctgactg cgattccctc 2777641 cgcatcaagc acagtcgcca catcgtgcgg atgaacatca tcaaggttaa atgtgacaag 2777701 cccggcacgc tcttccggcc cgtaaaccgt tacgccgtca agctggcgga agcgttcaag 2777761 cgcataagct gcaagcttgt gctcatggcg ggaaatctca tcaagaccga tttcttcgag 2777821 aaaatcaatg gcggcaccga ggccgattgc tcctgcaata atcggcgtac ccgcttcgaa 2777881 tttccacgga agctctttcc aagttgattc ataaagcccg acaaagtcga tcatttcacc 2777941 gccgaattcg gcaggctcca tgttttccag cagggctttc tttccgtaca gcacaccaac 2778001 accggtaggt ccgcacattt tatgggaaga aagcgcaaag aagtcgcaat cgagatcctg 2778061 cacgtcaatt ttcatgtgag gcgtgctttg tgcaccgtcc accacaatga cagccccatt 2778121 gtcatgagcg attttcgcca tttctttaat cgggttgacc gtgccgagaa cattagatac 2778181 atgagacacc gcaacaattt ttgtgttgct tgtgaccgtt tctctgacgt cttctaaaga 2778241 aatcgttccg tcttcctgca acggaatata ttttaatgtg gcgccagttg cttttacagc 2778301 ctgctgccac ggaatgatat tcgcatgatg ctccatgtag gtgatgacca cttcatcacc 2778361 aggtttcagg ttggcgcgcg catagcttaa cgccaccata ttcagtgatg tggtcgtgcc 2778421 ttttgtgaaa ataatctcag ccattgactt cgcgttaata aacttgcgga ctttttcacg 2778481 cgctccttca taaccatctg tcgctctggt tccaagtgta tggacgcccc ggtgaacatt 2778541 ggaattgtat tggttataat acttatccag tgtttcaatg acagcacgcg gcttctggga 2778601 agtcgccgcg ctgtcgagat aaacgagatc atgtccgttc acttgctgat gaaggatcgg 2778661 gaactgttca cgaatatctg tgatattcat tacttcactt tcctttcgat aacagaaact 2778721 aattgtttct taacgccttc aatcggaagt tcatttacta ccggtgcaag gaatccgtaa 2778781 atgactaagc gttctgcttc ttctttcgga attccgcggc tcatcaggta gtaaagctga 2778841 atagggtcca cacggccgac agatgccgca tgtcctgcag ttacatcgtc ttcgtcaatt 2778901 aaaagaatag ggtttgcgtc tccgcgtgct ttttcgctaa gcatcagcac gcgtgattct 2778961 tgctccgcat tcgctttaga agcgccatgt tcgattttgc cgattccgtt aaagatagaa 2779021 gaagcggaat ccttcatcac accgtgcttc aagatatagc cttcagaagc tttaccgaaa 2779081 tggatgattt gtgttgtgaa gttttctgtt tgctctcctc ttccgacaac aaccgttttc 2779141 gtatcgccgt atgtgccgtc accgtaaagg tttgttgtgt tttcggaaat cgtgtcgcca 2779201 tcgttcatca ggccgagagc ccactcgatt ttgctgtcgc gtccgcgcgc agcaccgcgg 2779261 cggttcacat aagttgtcac accgcttgac agattatcca ccgcaccgta tgtcacgctg 2779321 gcattatcac ctgtgatgac ctcactgata atattgaaga cagcgtcttt cgggtttaca 2779381 gtgctgatgt agttttctac atatgttaca gagctgtggt cttcagccac aatcagcacg 2779441 tggttgaata gagctgtatc attgctttcg tggacataaa cagcctgaac cggcgtctcc 2779501 acctgaacat ttttcggaac ataaaggaat gctcctccgt taacaagagc cgcgtgaagt 2779561 gcagttaact tatgttcgtc aaccttcacg ccgtccttca taaagtattt ctccaccaag 2779621 tcgctgtgct cgcgtgcagc agtcagaata tcagtgaaga tgacgccttt gtctttcaat 2779681 tcttgagaaa gagaaagatg tgccggcgtc tggtcacgct gtacgtataa tgttttatct 2779741 tcgttttcaa tgtcgatcag cgcttttact tcatcagtca aatcttctaa tgaagaaagc 2779801 ggttcgttat ccactgtatg cttcgcgaaa ttcgtgaagt tccagtttgt gatttttgtt 2779861 ttgtcaggtt tcggcatcgg cagatcctca gcttgttcaa gagcctgtaa gcgcaggttc 2779921 ttcagccagg caggttcttg gtgcttttcg gaaaagcttt tgagatactc ctgatctacg 2779981 gatagttttg tacctagtgt catattaatc cccctaacgc ttacgcttct tggccaacag 2780041 tttcgtcttc aatgccaagt tcttgtttga tccagtcata accttctgct tcaagacgct 2780101 gtgcaagctc tgcaccgccg gattttacaa cgcggccttg catcataacg tgaacaacat 2780161 ccggagtgat gtagtttaac aggcgctgat agtgagtgat catcaggcag ccgaagtttt 2780221 cgctgcgcat tttgttgatc ccttttgata caactttcaa agcgtcaata tcaaggcctg 2780281 agtcaatttc atcaaggatg gcgattttcg gttcaatcat cattaattga aggatttcgt 2780341 tgcgtttttt ctccccgcct gagaagcctt cgttaagata gcgctgagcc atttcagggt 2780401 ccatttcaag gaactccatg ttttcgtcca ttttgcggat gaatttcatg agagaaattt 2780461 catcgccttc ttctctgcgc gcgttgattg ctgagcgaag gaagtcggca tttgtcacac 2780521 cgctgatttc acttgggtac tgcattgcaa ggaataagcc tgcctgcgca cgctcgtcca 2780581 cttccatctc cagtacatct ttgccgtcaa gcgtgatgct gccttttgtt acttcatatt 2780641 taggatgccc cataatagca gctgataaag tggatttacc agttccgttc gggcccatta 2780701 ctgcgtggaa ttctccacct tttatttcaa ggtttacacc ctttaagatc tctttccctt 2780761 cgatttcaac gtgaagatct ttgatcgtta atgttgaagc agccatatct atacctccaa 2780821 aaatatataa tcattattct cattttattc tcattctaat tttataacaa atgaaaagta 2780881 aatacaactt tttatcgtgc cttgcacatt cctcaagttt aacaaagatc agcactttat 2780941 taaagcgatt gaaaaagaaa aagagtggat tcccaccctt ttttaaaaga ttgattttct 2781001 caataagctc ccgcagaaat ccgcttgctt ttttcataat caagctctct ctgccgctct 2781061 actttcattc ttgtttccag ccggcgtcca tattcctcgt atccaattcc gtgtgacagc 2781121 tgcatcgctt tttccatttc tgacgtataa tcgaggttca gtctgtcctg gctgctgcaa 2781181 ataatgaatc aatcccttca tatatttgct ttttattgta ccagtgctgc gttggatgcc 2781241 gcaaaaacga tttggcgtga aatagcggca gatgagacga aagcatcctt tcagaacaaa 2781301 tgagaatggt ttttcggaat attccttctc ttaatgcgtg gtgtttccga attcctcaat 2781361 gcactgttga acgactgtca cgccttggct gaaagctgcg ccgcctccaa atgccgctgc 2781421 cacactgacg gcttcgagaa tgttttcttc tgacgctccc tgatcaagac agccttttgt 2781481 atgatagatc atgcaatatt cgtcctgagc attgatggca attccgaggg cgatcagctg 2781541 tttttctctt tcagtcagag aattcccggc aaagcactgt tcagtaaatt cgttaaattt 2781601 tcttcccatc agcggcatct tttgttcaaa tgtgcctaaa ccatgtttat attgttttaa 2781661 cgcgtcctgc atgcttcctc tgtcttgatt caaagaaaat ccctccatct gtttaacatt 2781721 cctttttatt atgaacagct tttaggaaaa tacgcgaaaa aaaccccgga attctcatcc 2781781 ggggtttcag tcttattcag atacaggaag cacagctccg tcgtattttt tctcgatgaa 2781841 gtctttgatc tttttagagt gaagaacttc catcagcgct ttgatttttg cagaatcttc 2781901 ttcgcctttt cttactgcga tgatgttagc gtatgggttg tttttcgttg attctacttc 2781961 aattgcgtct tttttaggat ttaatttatt ttggatcgca tagtttacat tgatgaagac 2782021 cgcgtctcct tctttgtttt catatgcttt tgccgttaat tcaggcgcta cttttttgaa 2782081 ttcaaggttt ttcgggtttt tcttaatgtc tttcaatgtt gcgtcaactg tttccacttt 2782141 agaatcaaga gtgattaatc cagcgttttc aagcattgca agcatacggc cttgttcagc 2782201 aacgttgttt gtcagaatga ttgtcgcacc gtctggaagg tctttcagtg atttgtatgt 2782261 tttagagtaa ataccgaatg gctctaagtg aacagcgccg gcattcacaa gtttgtaatc 2782321 tgtgttttct ttcatttctt gctcaaggta aggaatgtgc tggaagtagt tcgcgtccac 2782381 ttctttatca gctaaagctt tattgtacat tttgtaatca ctaagcactt tcactttcag 2782441 cgtatagcct ttttctttca gcaatggttc agcttctttt aaaatttccg catgcggtgt 2782501 ttttgttgcc gcaacgacaa tttctttctt gccggattca gcgccgttat tcgaaccgca 2782561 ggcagccata actcctgcaa atacaagcag taatgcaccc aaaaatagct ttttcaatgt 2782621 aaatcctccc ttatcgtttg tctataatat ttgttattag atcaccgatg atttgaataa 2782681 taaacacgat gattaaaata aacacagtag caacgaaggt aacatcagcg ttattagact 2782741 gatatccttc tacgtacgca aggtttccaa ggcctcctga accaatggct ccggcaattg 2782801 ccgttgaacc gattaaagcg atggctgtaa ccgtaatgcc agaaataaga gcaggcattg 2782861 attccggaat cagcactttg aaaataatcg tagacgtttt cgcgcccatt gatttagctg 2782921 cttcaatcac acctttatcc acctcacgca gcgcgatttc aacaaggcgc gcgtaaaatg 2782981 gtgccgagcc gattaccagc gccggcaatg cggcgtttgg ccctaagatc gtgccgacta 2783041 aaaatttcgt aaaacctaat agtaaaataa ttaaaataag gaacggaatc gatctgaata 2783101 tgttaacaac ggctgcaatc actgagttga ccgctttatt ctgccagagg cttcctttgc 2783161 tcgtcagaaa gagcagcaag ccgaggatga ccccgatgac aaaagcaaac agtaaagaaa 2783221 tcagcgtcat ataaagtgtt tcatatgtcg cgttccataa ttcagttaaa tcaacgttcg 2783281 ggaagtattt ttcaaacatt cgtgatcacc tctgctttca cctgtttgtc attaatgaat 2783341 cggatcacgt tttgcacttc ttcctcgtcc ccgtcaatgt ggatgaacag tgaaccgtaa 2783401 gccccatcct tcgtctgcga aattttccct tgcagaatat tgacgctgac attgaagttt 2783461 ctgatcatct ctgtaatcag aggctgttca gctgactcac cgacaaatgt gagctgaacc 2783521 atttttcctg atgctgtatc atcaagaagg tgctgaagcg tctctttcgt ttcttccggc 2783581 tctgtcacct gttgaacaaa tcgttttgtc atttgttcct ttggattttt gaagacatcg 2783641 agaacctcgc cttcttcgac caccttgccg ttttccatga cggcgactct gttgcagatt 2783701 ttgcgtatga catgcatttc gtgcgtaatc agcacaatcg tcaaaccgag tctttcatta 2783761 atatcggaca atagatccag aattgaatct gtcgtttgcg gatctaatgc tgatgtcgct 2783821 tcgtcacaaa gaagaacctt cggattgttt gcaagcgctc tggcaattcc gacacgctgc 2783881 ttctgaccgc cgctcagctg ggacggataa gatttttctt ttccttctaa acctaccagt 2783941 ttaatcagtt cattggcgcg cttgatccgc tcgctctttt tcaccccggc aatttctaaa 2784001 ggaaacatga tattatctct gacagtccgc gaccaaagca aattgaaatg ctggaaaatc 2784061 atactgatct catggcgtgc ttttcttaaa ccgcgtccat ttacttcatt aatcttggtt 2784121 cccgccactt ccacggttcc tgaggttggt ttctcaaggc cgttcagcag acggattaag 2784181 gaactcttac cagctccgct atatcctata attccaaaaa tctcaccttt tttaatggaa 2784241 agcgagacgt tttggacagc attgacatct ccatgtttcg acttgtaaac ttttgaaaca 2784301 tcctgaagat tgatcaaagc aatcacctgc cttaacacta ttctaagaaa tcttccggtt 2784361 ttttctgcaa aagaaaagcc tttctgcaca cttgagcaga aaggcttata taaaatgcct 2784421 ttctctcatc tttcaaagct gaacgcttcg tgtgaattgg caccatttca acagtgttga 2784481 tggttgccgg gcttcatagg gcacttccct ccacctctct tgataagaga aatatatagt 2784541 ctttttcgtc cggaaattct taatgtagaa tagcacggcg aatgattaaa tgtcaataaa 2784601 ataaatgatg tcaactttta ctattataat aatttattat tttttaattt tttaaaatcc 2784661 tctgaaaaaa tccatttgtc agccagagaa tggcttccag ctttaacagg gccctgaatg 2784721 acccctttac tttgaggctt ccgctctgaa taaggtgctg aagggaaatg tctccgtgca 2784781 ataaatcaat aatttccgtt tggtttccgt aaaaggtcag gttggacgtt tggggcggag 2784841 aaactttttt catttctccc tgttcgttta ttgagacggt taaggcttct gcttctcctt 2784901 ggaaggtaat gagcaatgtt gaggcattca aaaggggttt taaaaacaga tgctgatact 2784961 catcttctaa aacttccgct ttctccatat gtacaacctc ctatttgttg gtcatacata 2785021 cacatttctc tctttgtcgc aagaacccct ttataaaacg aacgacaatt tcattggata 2785081 tgctgagaaa tatgtcataa atgggatgcg gaagatgatt tttgtttgat cagctcatat 2785141 aaataagaaa cggaatgaaa tgcatatcct ctttcgacca tctttccgcc tttaaacagc 2785201 agaaaacaag ggacgctttc aatttgatac gcttttgcga atgtcggaga gtaattgaca 2785261 ttgttttgat agaaggcgac atccggcagc atttctttca ccactgtcag cattttgctt 2785321 gcaagctggc aggtgccgca aaacggagta tataaatata gaaggtacac atcatcttca 2785381 atgtgatcaa gttcgtgttc ttggagttct ttcatgctat acacctcggg actttctttc 2785441 aagaaaaata gtatggacat tcagattcgc acgcagcaat acagaagcga tatggtgcct 2785501 gggcgcagcc gctacttcct tataggctct gtcgacatgg agatggcagg cttcattaaa 2785561 ttcacgcttc agctgttttc tcaatttctc acctgattca tcagcatcaa ctaatatata 2785621 gacgtcttta tcataaagct cgtcagccaa ttcctcgagc ctcagctggc tgattgttcc 2785681 gtttgtgcag ataatgcgca tcggttcatt caggacgctt tcgattttct ctttatctga 2785741 tttcccctcg acaatcataa ccttttccag ctcatccatc ttcatcttgt tcacctgccg 2785801 cgtcaaattt gaaatgttca gattgtaaaa gaaggcagtg aaattcaccg ccaacattaa 2785861 caccagccgt tttcgtagtc acaatctaca tattttgcgt cgtctccaga gaccacatcg 2785921 gctgtcttat aaaatttctc attttcaaag gaataaccgg acttaagctc atattcattc 2785981 atgcttgtca tttggccgat catctcatta tcatgatata acgagagccg gccattttga 2786041 aagcggcctg tcacgtcatt ggtgacatcg agcttttgtt tgtcgaaagc catattggac 2786101 acctcccata acgttagcgt gtccaattgc ttttacggct atcctgtttt agtcttcttg 2786161 tgtcatctct tcgtattgct ctgctgtcat cagtttttca atttcagaag cgtcagatgg 2786221 ctcaacgacg atcatccatg ctttttcgta cggagattcg ttgacgaatt ccggactgtc 2786281 atcaagatct tcgtttactt ccacaaccgt tccgttaatc ggtgcataaa gctcagatac 2786341 cgttttaacg gattcaacac tgccgaatgg ctcgtccgct ttgatttcag cgcccacttc 2786401 aggaagttcg acaaacacga tgtcgcctag ttcggactgg gcaaaatgcg taattccgat 2786461 tctggctttt tctccttcaa cttttaccca ctcgtgttct cctgagtaac gcaaatcttt 2786521 tggtatgctc aattgaatcc ctccattttt tacagcacta caataagaag ataccacact 2786581 tttcaaaaaa aatttacatt aagcccagtt ttcttcaaat tggtcttctt taaatccgac 2786641 agtcactttt tcgccgtctg ttgtaagcgg gcgtttaatt agcataccat ctgaagccag 2786701 cagttcgagc tgttcgtcct ctgacatatg atacagcttt tccttgagat tgagctcgcg 2786761 gtatttcatg ccgctcgtgt tgaaaaattt cttgagatcc agcccgcttt tttcataaag 2786821 cgcttttaat tcttctttgc ttggcggctg ctcagcaata tgtatttcgt ttatttcttt 2786881 cccatgctct tcaagccact tctttgcttt gcggcacgtt ccgcatttag ggtaccagta 2786941 aaaagttaac gacatcttct tccccctcaa taaaataatc gaggttattt taacacagtt 2787001 tgttttaaaa acctaaaaca gtgcttctta aaaaagagct ccgcgcatgc ggagctcatg 2787061 gccaatcaga cagtatattt ctcagcctca aaaatgcctg ccgccgcctc gcgttttttc 2787121 tgaatcacgt ttttaggcgt tacgcgtgtc agcttgcgca gagcggaaag catcatgcgg 2787181 agtgaatctc cttcttccat tgcgataagg gattcctttg catgcgcttc gatttcgtta 2787241 aaggcctctt gaacgaaaat ttctgtgtac agcacctttt gcgctgcttt ttcagcgcct 2787301 tgtgcggcaa tggccttttc cgttctgagc acggctgatt ccattgcgta tacattgctg 2787361 acgatatccg ctacgttcac gagaatttct tgctcacgat cgatcgcttt tccgtatttt 2787421 tgcgcggcta ggccggcagc aaacaacgca atttttttgg cttgcttgac gatatatttc 2787481 tcctgctcta agacgccgct tccaggctct tcaggcataa gcatcatgag ttcttcctgc 2787541 agcgactgcg ctttttcgaa taaaggcagc tcgcctttaa gcgctttttt caggaaggtg 2787601 cttggcacga ttaaccggtt gatttcgttt gtgccttcaa aaatccgatt gatccttgaa 2787661 tccctatagg ccctttctac ttcgtattcc tgcataaagc cgtagcctcc atgaatctgc 2787721 acgccttcat caacgatata atcaagcgtt tcagagccga ataccttatt cagagagcat 2787781 tcgatggcgt attccgcaat cgatttggcg atttgccggc cgtccttgag atcttcggcc 2787841 gtgaactggc tcatattgtc ttcaaacagc ccgacggttc tgtatacaga gctttccatc 2787901 gcatacagcc ttgaggccat tgtcccgatt ttttcctgtg tcaatgaaaa accagcaatc 2787961 ggcgttttaa attggcggcg ctgatttgcg tatgccgcag acagctcgat gacgcgttta 2788021 gatgcgccga ttgtgccaac cgccagtttg taacggccga tgtttaaaat attaaaggcg 2788081 atgacatgcc ctttgccgat ttctccgagc aggttttcct ttggcacttc agcttgatcc 2788141 agaatgaggg ttcttgtcga tgatcccttg attcccattt tcttttcttc cggtcccgtg 2788201 gagacacccg ggaactcttt ttctacaata aaggctgaaa acttgtcgcc gtctacctta 2788261 gcgtaaacta caaatacatc ggcaaaagca gagttggtaa tccactgttt ttcccctgtt 2788321 aatacataat gggttcctgc ttcattcagc acagctgttg tttttgctcc aagtgcatca 2788381 gacccagagc caggctcagt cagagcataa gcggcgatct tttcgcctga agcgagtcca 2788441 ggcaaatatt ttttcttttg ttcttctgac ccgaaaaaga cgatcggcaa ggaaccgata 2788501 ccgacatgcg cgccataaga aagagaaaag cttcccgcac gcgaaaattt ctcagtgatg 2788561 agtgccgagc tgattttatc aaggccgagc ccgccgtatt cttccggcac atcggcgcca 2788621 agcagcccta gttcgcccgc tttcttcaac agtctgacag aatgctcgaa ttgatggttt 2788681 tcgatatcat ctatatgagg gagaacatct tgctcgatgt aatcctctgt tgttttcgca 2788741 atcattttat gctcgtcagt gaaatcctcc ggtgtataca tttgatcgta tgtgacatcc 2788801 tcgattaaaa atccgccgcc tttttgtacg tcagccgctt tttttgccat ttgtttttcc 2788861 ccctttagca taattcaaat acaccggccg ctcccattcc gccgccgata cacatggtca 2788921 cgactccaaa ttgctcgttt ctccgtttca tttcatggat gagtgagagt gtaagctttg 2788981 tgcccgtaca gccaagcggg tgtccaagcg cgattgcgcc cccgttgaca ttcacttttt 2789041 cttcatcaat tcccaattcc ctgattactt gaatggcctg tgaggcaaaa gcttcattca 2789101 gttcaaacaa gccgatgtcc tgcagctgaa gtccggcaag cttcaaagcg cgcggaatcg 2789161 cttccaccgg tccgattccc atcacttccg gcggcacgcc gcctaccgca aaggagcgga 2789221 atttcacaag cggcgccagg ccaagagcat cggctttttc ccggtccatc agcatgacag 2789281 ccgccgctcc gtcactcgtt tgtgaggaat tgcccgcagt caccgtcccg tcaacggaaa 2789341 aggccgggcg caatgtcgat aagatgtctg cagtcgtttg cgggcgaaca ccttcatcct 2789401 gagaaaacac aaactgtttt tccataggct tatggtcttc tccgatttct gtcaccgtca 2789461 cttcgacggg tacaatttca tctttaaatt ttccttctgc aagggcttta gcggcgtttt 2789521 gatggctgcg aacggcaaac gcgtcttgat cctcacggga gacgccgtat tttttcgcga 2789581 cttgctcggc tgtgtgcccc atgctcatat aatattccgg tgccttttct gccaaagcaa 2789641 ggttcggacg ggtaacatgc cccatcatcg gaacttgcga catggattct gctccgccgg 2789701 cgatcgctgt atcgtaggcg cccagcataa ttttttctgc tgcatacgca atagactgaa 2789761 ggcctgaaga gcaatagcgg ttaactgtaa tcgccggaac cgtgtacggc aggcccgcga 2789821 gcgcaccgat atttctcgcc atattaagcc cctgctccgc ttcaggtgtt gcacagccga 2789881 taatcaagtc atcaatattg ccttcgtagc cgcctgcccg tttcagcgtt tcttttacac 2789941 aaatcgctcc caaatcatcc gggcgaacgg tggccaacga tccttttttt gcttttccaa 2790001 ccggtgttct tgcacctgac acaatgactg cctctttcat aagctccctc ctaattccgt 2790061 aaaggtttac ctttcacaag catatgctgc attctcgctt gagattttgc ctctcctgac 2790121 aaactcaaaa acgcttctct ttcgatctcc aataaatact cttcatcaac ctctgtacca 2790181 aacggcactt ttccgcccgc aatgacataa gcgagttttt tcgcgatctt aaaatcatgc 2790241 tcagatatat agccggacag cttcatctgc tcagcgccaa gcaagagtgc cgcataaccg 2790301 gtttctcccg gcaccttgac cttttctttt acaggcggcc gccagccggt atcgtataaa 2790361 gatgcggcca gctgcttcgc atcgtataac aggtggtctt gattcacgct gatctgatcc 2790421 gtttctttta agatgttcat ctcacgagcc tcttgagcgg aagcggacac tttcgccatc 2790481 gcgattgttt caaatgtttt cattgccgca ttcatcggat catggccgcg gcgaagatgg 2790541 ttgatgtaca gctctttgtt acctcctccg ccagggatga ggccgacacc ggattccaca 2790601 agtcccatat aggcttcgct tgccgcttga atgcgcgccg ccggcaggca tgcttccgtt 2790661 cctccgccga gcgtcatgcc aaatggcgcg gcgacgaccg gtttcgcact gtatttgatc 2790721 ttcatcatcg tctcctgaaa acggcggatc acaaaatcaa cttccaaaaa gttgtcatct 2790781 tggacttcca ttaagatcat ggcgagattc gcgccgacgc agaaattttt cccttgattg 2790841 ccgatgacaa gccccttgta attccgttct gtttcctcta atcctttgtg gatcatttga 2790901 atgatatcga ggccgatcgc attgcttttc gaatgaaatt caagaagggc cacatcatct 2790961 ccaaggtcaa ttaagcttgc tccgctgttt ttcgcaatca cgccttttgt ttctttaagt 2791021 gcttgtaaat gaattcgttt tttgttttct ttcacggctc tgtattcgcc gcggtcataa 2791081 taaaataccg ttccgttctc tttgatgtag aaggtttcat ttcctttgtc cagcatctct 2791141 tttatccagc caggcatatc tgctccaagc tgctcaagct tttccgctga ctgcttgagg 2791201 ccgatggcgt cccacatctc aaaaggtccc agttcccagc cgaatcccca cttcatggct 2791261 tggtcaatcg catgaatatc atcggcaatc tcgccaagca gctcggctga gtaaagcagg 2791321 gtttgagaag tgatattcca cagcaaacgg ccggccctgt catccgaata aataagcgct 2791381 ttcattttgg cttttgtccc ttttgcctgt tttgccgctt caagtgccgg tgatttcatt 2791441 tttgtccgct cgccgtaagt aagcgtcact gggtcaagct cataaatcgt ttttccttct 2791501 tttttataaa agccttggcc ggccttgctt ccgatccacc ctttttccag catatcgttc 2791561 atgaagcttg gaatgcgaaa cacttctttt tcatcgccat cagctttgtc atacacattt 2791621 cgggcaacgt gggcgaatgt atcgaggccg accacatcaa gcgttctaaa ggtggcgctt 2791681 ttcggcctgc cgatcagcgg tcctgtgatc gaatcaacct ccccgacctg ataaccgcct 2791741 ttcagcattt cttggactgt cacgagaagc ccgtaagtcc cgatgcggtt tgcgataaag 2791801 ttcggtgtgt cctttgctgt aacaacgcct ttcccgagga cattttctcc gaaagctgtc 2791861 ataaacttta aaatatcagg atccgtttcc ttaatcggaa tgatctctag cagctttaaa 2791921 tatcgtgcgg gattaaaaaa atgcgttcca agaaaatggg ctttaaaatc atccgaccgg 2791981 ccttcagcca tttcctgcac tgatatgccg gatgtgttgc ttgagacgat gcttccagtc 2792041 tttcgatgtt catccacaag agcgaaaatt ttctttttga cttcaaggtt ttcgacaacg 2792101 acctcaataa tccaatctgc ttctttcagt ttttctgcat catcctccag attgccaggt 2792161 gtaatatagg aggtattttt cgctgatgtg aggggagcgg gcttttgttt cagcagtttt 2792221 ttcatcgcct gccggctcag cctgctgcgc acctccgaac tgtccttcgt cagccccttt 2792281 ttttcctctt cctttgtcaa atcgttcggc acaatatcta gcagcaggac aggaattccg 2792341 atgttagcca aatgcgccgc tatcccggaa cccattaccc ccgatcctaa aacggctgcc 2792401 ttccgaatgt gtttgtgcat gagatatccc ccttgaacat tgaatgaata gtcattcatt 2792461 ttttgactaa aaaaaatgaa acccgtttct tctttcatct taaaagattt ccggttcgac 2792521 ttcaatagct aatttgttat ttttttgtat gaagcctata aaagtcgggc aacttaagcc 2792581 cggaggtgaa gggaatggta cgagagaaaa aaaatccgtc ttcagcggca gtcagcgcgg 2792641 cgagcgtaaa gggagatgcc ggtccgactc agcattacgg cggcggaaaa cggacaagtc 2792701 aaaatcagca gtataaaaaa cataacatgg gacaatcata atgcagctgc ttcccacggc 2792761 tgctttcact ttttcaaaat tccttttaac acaaacgctg cattggcagg ccgttcggca 2792821 attcttctca taaagtagct gaaccagtcc gttccatatg ggacatacac acgcattctg 2792881 tagccttcct tggcgagttc cttctgacgc tccggcctga tgccgtatag catttgaaac 2792941 tcaaattgcg atgcggggat ttgatgttcg gcgacgagct gtttcgtaaa tgcaatgatg 2793001 tcatcgtcat gtgtggcgac agccgtgtag ttcccgctta acaactgcag ctttattaag 2793061 ctctgaaaat gaaggtccgt gcctcttttg tcgggaaacg ctacagccgc agattcttta 2793121 taagcgcctt ttacaagtct gagattcggc tttaagtccc gcatctttct gatatcttct 2793181 gccgcccggt acaaatacgc ctgaatgacc gtgccgagct tctcaaattc ctgtttgcat 2793241 tgcctgtaaa tagaaagtgt ctgttcataa tgagaatagt cttccatatc aatggtcaca 2793301 gcaacatcat attgcttcgc aacggaaaga atggcgcgca aatgagtaag agcaagttct 2793361 tctgaaagat cgagcccgat tgaggtcagc ttaagtgaaa gctctgaatt caattgatgt 2793421 tcggcaatgg cttgaatggc tttcttgcat tcctctgcga cttggtttgc ttctttttcc 2793481 gaagctgcat actcgcctaa ataatcaatt gttgcacaca aaccggatct gtttagcctt 2793541 ttgacggtct taaccgccga ttcaatcgta tcccctgcga caaaccttcg tgctccaagc 2793601 cgcgttccgt atgcttttgc gaacttggta agtgttttat tttgagataa gaataaaaac 2793661 acatgtctca acatccgact ccctcccgcc gtcatcttca aaacacctgt atataactcc 2793721 cagtctgaag gaaactataa aatgaacaga aaccaaagga ggatcacaat ggataatcag 2793781 cagcaatctc aaatgccgcc ttccgttatt tcgacaaagg atcatttgta tctcaatgac 2793841 atgctgaact ggaatttgct cgcgatgaaa aaagcgcatt tcatggcgca gcagtgccag 2793901 gatcaaacgt taaagcaaga actcgaccgc gtcggacaca tgcatcatga tcactatcaa 2793961 agaatattaa agcacctgca gccaggccag cagcagtccg gctacatcca ataaggaggc 2794021 gccagaatga atcagcaaaa tcaaaaaatc agcaacccgc agacacctgt accgacaaca 2794081 tcggaaatga atgacagaga tttcgtcaac gaattgctga caaccgaaaa atacatgaca 2794141 acagcttatt gcactgcctt gcacgaattc agccacgagt ctctttatca ggatattcaa 2794201 tccatttttg atgagtcaca aaaagcgcaa agaaaactat atgatctcat gttccaatat 2794261 ggatggtatt ctgttgaagc ggaggattca caaaagctgc agcagtccta tcaaaaattc 2794321 cagcagacca ttcagcagca gtctccttat cagcaataac aacattagta aaaaggatac 2794381 gatgttcttt cgggcatcta tccttttttt gtgtaaaatc agttgacttt tcatttacgc 2794441 ttatttatat ttaataagca ttaactattt tgtcattaaa atatatatac agtgtatgta 2794501 acagagggga aatgaatatg aagagtgcgg atcagttaat gtccgatatt caattatcgc 2794561 ttcaggcgct ctttcaaaag atacagcctg aaatgctgga aagcatggag aaacaaggtg 2794621 tcaccccagc gcagctgttt gtgctggcca gcctaaagaa acacggcagc ctcaaagttt 2794681 ctgaaattgc cgagcgtatg gaggtgaagc caagcgcggt gacgctgatg gcagatcgcc 2794741 ttgaacaaaa aaatcttatc gccagaacac acaacacaaa agacaggcga gtgattgatc 2794801 tcagtcttac tgacgaagga gacataaagt tcgaggaggt tttggcgggc agaaaagcca 2794861 taatggcgcg ctatctttcc tttttgacgg aggaggaaat gctgcaggcg gcgcatatta 2794921 cagcaaaact cgcacaagca gcagaaacgg atgaaaagca aaacatgaaa agaggaaacg 2794981 gatgaaaatg agtaaagaag gcaaacaatc aaaacgaacg ttattaataa caggcttaat 2795041 tattgccatg tttttttcag cccttgacgg taccattgtc ggaacggcca tgccgaaaat 2795101 tgtcggtgat ctgggcggtt tgagcatgat gacctggctg acaactgcat atttgttaac 2795161 atcaacaacc attgttccaa ttgccggtaa actggctgat ttattgggac gccgcattgt 2795221 ctatgtatca ggtttgatta tttttatggc cgcttctgct ttgtgcggaa tggccaacaa 2795281 catgacggaa ttgattatct tccgtggact gcagggcatc ggcggaggca tcatgatgcc 2795341 gatggcgatg attgtcatcg gtgacttgtt cacaggaaaa cagcgtgcta aattccaagg 2795401 tgtctttggc gcaatttacg ggctggcttc agtgattggg ccgcaaatcg gcggctggat 2795461 tgtagactcg ttaaactgga aatgggtttt ctatattaac ctgccagtcg gaattattgc 2795521 ggttattttt attgccaggg gattacaggg acgccagcag actggtccga tcaacttcga 2795581 tatcgctggt attttcacaa tgattgtcgg tgtggtcagc ctcctgctcg ccttaagctt 2795641 tggcggaaaa gattatgcat gggattcatg gcagattctt gggttgttcg ctctcgcact 2795701 gatcggcatt gtcagcttta tcatcgtaga atcaaaagca aaagagccaa tcctgccaat 2795761 gtatttattt aaaaacagaa catttacatt tctaaacttg atcggcttct ttatgagtat 2795821 cggtatgttt ggcgccatta cgtttgttcc tttctttatg cagggaattg tcggtgtaag 2795881 tgcgtctgaa tcgggtacaa ttatgacacc gatgatgatt tctatgatta tcacaagtat 2795941 catcggcgga cagcttgttt ataaaattgg gattaaaccg caaatcatta caggcatgct 2796001 ggttatggcc ggcggattcc tgctgttaac gacattggat ctcgacacga gcaagcttgt 2796061 cgctacatct tttatggcga ttattggtct gggaatgggt cttgttatgc cgattctgac 2796121 attggcttta caggaaagct tttcgaagga ggagcttgga gttgtcactt catccagcca 2796181 attcttccgt tctatcggcg gaacattcgg cattaccatg ctgggagccg taatgaatgc 2796241 gagatcagga aatctattaa cagataaatt ggttccatat ttagactctc ttccggcaca 2796301 ggcaagctcg tttgccgccc agctaaaggg tatgattgat acaaatccgc aagggctgct 2796361 gcaatcactg ttcagtccgg acgcggtcaa acaaatccct gcggctttct catcccatat 2796421 tgtgccgatt ttaaaaacat cgttgatgga ttcgctccac agcgtgtttt atacgggcct 2796481 gatctttatc gcagtcggag ccgtattcac cttgttctta aaacctatca agctatcaaa 2796541 taagaaagcg gaagaccaac aagaaaaaga gaaggcggca aaagccgttg aatcaccttc 2796601 ccattaatag agcaccccgc gggtatcaat ccgcggggtt ttttattcaa tcatctgggc 2796661 tcttccattt ccgaaagacc aatcctcatc ctgatttccg gccagcatga taaacacatc 2796721 ttcttttctt acaccaagct cggaatgaat ccggctcgcg attgagcggt aaagtgcttt 2796781 tttctgttca gttgttcttg actgtttcag tgtaaaatga atgtatatca gttcatcagt 2796841 acgctcgact tggagataaa atggatcata aaaaaattcg cttttttcat attgtctgat 2796901 gacttggaaa tagtcatctt ccggcacatt gatttcttca atcatcgatt ggtggatagt 2796961 cctgctcagt ttttgaagcc acacttcgct tcttcccgac cgtaaatgaa tctgtacaaa 2797021 tggcatctcc ccgcatccct ttctttacag cgtctgtccg ctgtcaattg tgataatttg 2797081 gcctgtgagt gattcctgtt caattagtga acaaatcaat ttggcaacat catctggttc 2797141 agcaatacac tgcagcagca aagagccgat catgcttttc attttttctt cccgtccggc 2797201 ccaccatctc gttgccacag ctcctggtgc tacaccgctc actctgattt caggcgctaa 2797261 ggcgtgggcc aatgatttcg ttaaaccgtg caccgctgat tttgatactg cgtaaggcat 2797321 tgatgagccg gcaccagtta tccctgcgat gctgccgacg tttacgatcg ccccgtcctt 2797381 gcttttcttc atgaacggaa ccactgcccg cgcgcagaaa aacatccctt tcacattgac 2797441 ggcatacagc tcatcctaga cgtcttctgt cgcagcctca agatcatcca ttggaatatg 2797501 ccgtgtaatg ctggcattgt tgactaaaat atcaaccgtg ccgtgtgtgt tcacgattgc 2797561 ttgaatcata tcctgcacgt cgctgttttt ggatacatct gcttggatgg cgaaggcttg 2797621 cccgccagct ttttgaatca tttccactgt ttcctccgct tctgattgcg agcgtgaata 2797681 attcaccgcc acaatcgccc cacgctttgc caattccata ctggctgctt ttccgattcc 2797741 tgtgccgccc cccgttacga gagctatttt gttcaagaca ttcattgccg ccactccttg 2797801 ctgttgacta aagtatattt ctgattccat tgtaatccag ctttgatgtt acgtataatg 2797861 attgttaaag atactagata tcactcagat tgatagtaaa cgaacggagg agttcaaaat 2797921 ggaaagcgga gatttacgtg tgtttcaaat ggtagctcgt gaagggacca ttacgaaagc 2797981 agccctgcag cttggctatg tacaatcgaa tgtcacggcc agaattcaac aattggaagc 2798041 tgagctgggt accacactgt ttttgcgcca taatcggggc atgacacttt ctgcaagcgg 2798101 aaaattgctg ctggactacg caaataaaat tataggcctt cttgatgaag cgtctaaagc 2798161 gctctcatcc tccgcagaac caagcgggcc gcttatgatc ggctgcactc agacaaccgc 2798221 cgcggtaagg cttccaaagc ttctggcatc ttattatgaa gaacatccaa acgtccagct 2798281 gtctttaaca acaggacata cgcaatttct ccttgataaa gttcttcgtt atgaattgga 2798341 tggcgcgttt atcggatgcg aatgccatca tcctgagctc gaatcctatc ctgcgtttga 2798401 ggaagaacca gtagttgttt cggctgcctc cgtgcccgat gttgaggaag ccatcacaaa 2798461 gccgattctc gtttacagca caggctgttc gtatcgagaa acacttgaaa aatggctgcg 2798521 ttccgtcggt gtcacacagc cggtcattat ggaatttggg acgcttgaag caattatcgg 2798581 cggggttaca gcaggtcttg gcatctcgtt gctgccaaga acggttgtgc agaaacatga 2798641 agcagaagga tcaattcgat tgtacccgct gcctgaagct ctcagccaga tgaaaacaga 2798701 gtttattgtt cgaaaagatt cgtttatcag cagcgcgctg agaaccttta tggattcctt 2798761 tacgccagtt aaaacggctg aatcacaaaa aagcagtctg ctataatgaa cagactgctt 2798821 tttggctatt gtttgtttcg atgcgcttca tttaattcct taatatgctg aatgatctct 2798881 ttaatgccct gcttcgcgtc ggggtatgtc gcattccaat gcttagcgag cggaggcatg 2798941 cttttggcta tatgggtgta caaaatccat tgcttcactt cttcttttag ctcatcgttt 2799001 gtttcaccaa gcagaagctc agtatacttc tccagcaatc catcaagctg ctcctgaagt 2799061 ttttgttcca ttttccatct tcctttcgaa aaaacagcaa ggagctttct caattgaaag 2799121 ctccttcgct gcgttattta tccatgtgat gtgaaagccg cttcctggac aatgcatctg 2799181 cccctgccat gaggaatgca aagaggcgtt ccgaagagcg ggtcctgtgt aacctgacag 2799241 ttcatagaaa acacattttg cacaagatca caagtgatga cctcttccgg acggccttct 2799301 gcataaatcc gtttatcttt tatggccaca agatgatgcg catagcggca cgccaagttt 2799361 aagtcatgga gaaccataac aatcgtccgg tcttcctttt cattcagctc aaacagcaaa 2799421 tcaagaattt caatttgatg cgtcatgtct aaatacgtcg tcggctcgtc aagaaggatg 2799481 atatccgttt cctgggcaag cgtcatcgcg atccaagccc gctggcgctg tccgcctgac 2799541 aaagaatcaa cggcacggtc agccatgtcc tcaagctttg ttgctttaag cgctctttca 2799601 actgcttcct catcctcttt tgaccactgc ttcagccagt tttggtaagg atatcttcct 2799661 tgcttcacca gctgatgcac cgtcagcccc tctggagccg aaggaccttg gggcaggatt 2799721 gcgagctctt ttgcgacttc cttcgtcgga agcttggcaa tcgctcttcc ttccagcagc 2799781 actgaaccgc ctctcggctt catcaggcgc gctaatgaac gtaaaagtgt cgattttccg 2799841 cagccattgc tgccaataaa tacggtaatt tcacctttgg gaattgttaa attcaactca 2799901 tcaataataa cggcatcccc gtatcctaag ctcagcgttt ctgtagaaat tgcactcata 2799961 cccataaccg ctcctttttg ctggcttttt agcagcacta tgtattgcac gttttctata 2800021 tacatgcttt taagtcaatt gtcatcaatg caaatgattc cgatattcag ccatttgata 2800081 tggtcatata tccctcattg tagcagaaaa cactgacttt gaaaatcatt ttcaattagt 2800141 tttatggaca taattgacgt ttatgggttt tttatcacaa gattacttct tgatttctct 2800201 gatggagccg tccttcagct tcaattttaa atcgatatga tcataatgac tgtccagatt 2800261 aaatgctgcc agcacactgt gtatcacttc tgtttcagcc atttggtctg tcacggaaag 2800321 ctcgctcaaa atcattttca tctcatctaa cgcttcttct ccttcctgat tgacaccgga 2800381 gagcttatcc tgtatttccg ctttttcctg agtcccgttc tttgtataga ttccttcata 2800441 acggttatgc tcaccatccc cgtagctcac acgaagcgaa aaattactgt agggaacgga 2800501 cttcagctgg gtgacggctg tattttctcc ttctgcctga tgctggtctt cattgaaacg 2800561 gcagcccgca atcagaacca ctgcgagaca tacagccccg gctgctctga tcaaatgcat 2800621 atgtttcccc cctgtaggat tccatttatt ttaggtatat ccagagaatg aaatcctcat 2800681 tcagagaaga attgaaaaag ccggggcatt taacgccacg gctttttctt taagattcgg 2800741 tcatttgtaa aaaggtttcg gcgtcacgca cagccagctt gatggcattc tcccagaaat 2800801 cgcgctttgt gatgtcagcg cccaaatgct tcatcgccaa atcctccact gtcatagaag 2800861 ccgtatcgcg caatagcgcc atatacttct cttcgaatgt gtctttttct tcaagcgcca 2800921 acgcgtaaat accaagagaa aacaggtagc cgaatgtata agggaaattg taaaacggca 2800981 ccctcgtgat gtgaaaatga agctttgatg cccaaaaaag cggatgatat tcttctaacg 2801041 cattgcagta tgcctctctt tgcgcctctt ccatcagctc attcaagcgg ctggccggta 2801101 ccactccccg ctttcgttcc tcgtagaatc tcgtttcaaa tagaaatctt gcgtgaatgt 2801161 tcatgaagaa cgcaacgctt ctttgcactt tatcctccag aagaacaagc ttttcttccc 2801221 tcgtctcggc ctgctggaca gtcgcgtccg ccactatcat ctctgcaaac gttgaagctg 2801281 tttctgcaac gttcatggcg taggaacggt ttaacggcct gacgttgagc attgcttcct 2801341 gatggaacgc gtgcccgagt tcatgcgcaa gggtagagac atttgaggcg cttcccgaaa 2801401 atgtcatgaa aatccgggat tccccgctgt ccggaaaact ggtgcaaaag ccgccgactc 2801461 tttttccgct cctgtcttcc gcctcaatcc agccgtcccg aaacgctttt tcagtgaatg 2801521 aggacagctt tttgccaaac gttgaaaact ggctggtaat gatatttgcg gcttcatcat 2801581 acgaatagac ctttccgtca gaaccgatcg gtgcctcgac atcgtaccag ctgagttttt 2801641 caaggccgag catggatgct ttccggttca aaaactgaac gaacggcttc ttgttttcag 2801701 tgatgacctg ccacatcgta tcaagtgttt cttttttcat cctgttaatt tgcagcggtt 2801761 ccttcaggac attctcccag ccgcgcgctt tataggtttc aagccggaat cccgccaaat 2801821 gattcagcgt gctgctgaaa atatcttgct tgctctccca agcttggcgg aaacgttcat 2801881 atactgtttt tctgacagta cggtcttgat gatccatcat attctccgcc tgaccgacag 2801941 acaattgctt gttttcaccg ttttcctcat acgggatcgt cattttcccg acaaccatat 2802001 tgtataagtc actccaagcg tgatatccgt ccaccgcaag gtttccgatc agtttttcct 2802061 taccggggct aagcttttcg gcaaccctct gtcttctttc atttaatatg taagaaacat 2802121 cgcgcaatcc cggttttgtt aacaattcat tccacacgtc ttgattaatg tccacaagtt 2802181 tatgatctaa tgtaacgagc gacgattgaa aatctgcgga aagccgattc atgaggcctg 2802241 atgctctata gccttttgat cattgatatt ctgggcctgg aggcaagcaa caaaagcgcc 2802301 ggcctgctga agcttgacgg atgtctgttc gaataaatca agcaacgcgg tcagcccttc 2802361 agcctcttca ggcgattcag gcacctgaaa cgcatcagtc ctgtcttgaa atgcacgcag 2802421 actttgtgac agcttctcaa tataaccttt gaattcttcc gattggctcc cgcccttaaa 2802481 aaatgaatca agatcccatc tttggcctac cccttgcagc gccatatcac aaaacccctt 2802541 tccttctttc gttctattat agaacaattc tgaattattg tataaaaatt tctattacag 2802601 gcgtcatttc gtgttcagga tagtacaata gctgtagcag tttaatagga gggttaggat 2802661 gaataaaaaa atagccatcg tgacaggagc gtccagcggc ttcggtctgc tggcagctgt 2802721 aaagcttgcc cgatcatttt tcgtgatagc cacatcaaga cagcctgaaa aagcggaaca 2802781 gcttcgagaa ttggctgcag cacacaatgt gtctgattct attcacatta cagctctcga 2802841 tgtcaccgat gaacaatcta tagtctcatt cggaaaagct gttagtgctt acgccccgat 2802901 cgatttactc gttaacaacg ccggaacggc ttatggagga tttatcgagg atgtgccgat 2802961 ggaacatttc agacaacaat ttgaaacgaa tgtcttcggt gtgatccatg tgacaaaaac 2803021 cgtgctgcct tacataagaa agcatggcgg cgcaaagatt ataaacgtga gcagcatcag 2803081 cggactgaca ggattcccag cgctgtcgcc atatgtttct tccaagcatg cattggaagg 2803141 tttttctgaa agcctgcgta tcgagctgct tccgttcggt atcgaaaccg ctttgatcga 2803201 gccgggctca tacaagacat cgatctggtc aacgtcatta tcaaatttta tgtcggtgcc 2803261 tgctgacgat tcagcctatc atcaatacta taaaaagatc ctttcctatg ttcaaaaaaa 2803321 cggagaagaa agcggagatc cccaagaggt tgccgacctc atttatcaat tggcaacaaa 2803381 acagcacata aagaatttgc gatacccgat cggaaagggc atcaagctca ccctgctgtt 2803441 ccgatcgctt tttccttggt ctgcgtggga gtctatcctg aagaaaaagc tattcagctg 2803501 atctaaatta taattattat aatttagtat tgatttttat ttagtatatg atataattaa 2803561 gtcaacagat cacaaggagg acgttatctt atgaaaactg aaaacgcaaa aacaaatcaa 2803621 acattagttg agaattcact gaacacacaa ttatcaaact ggtttctttt atactctaag 2803681 ctccaccgtt tccattggta tgtgaaaggg cctcatttct ttacattgca cgagaaattt 2803741 gaagaacttt atgaccatgc ggctgaaaca gtggatacca tcgctgagcg cctgctggcg 2803801 attggcggac agcctgttgc cacagtgaaa gaatacactg agcatgcatc tatcacagac 2803861 ggcggaaacg aaacatcagc atcagaaatg gtacaagcat tggtaaacga ctacaaacaa 2803921 atcagcagcg aatctaaatt cgtgatcggc ctggctgaag aaaatcaaga caatgcgaca 2803981 gcggacttgt ttgtcggatt aattgaagaa gttgaaaaac aagtgtggat gctttcctct 2804041 tatttagggt aacaaaaaag ctgaacctta atcgggttca gctttttgtt ttttcttagc 2804101 ttgaactgct ttctgtctgc ttggtcagtg ttgcgttcaa cgttttcgtt tttccctttc 2804161 gcagcacttg gattgttgtt ttatctccga cttttaagtc tttgtaaagg atctgacgga 2804221 tatccgcact gctttccacg tctttaccgt ttagtttgac aatgacatcc tcagatttaa 2804281 tacctgcttt ttctgccggc gaatttgctt gaacttcttt tacataaaca cctttgccca 2804341 attgatctcc aaacaggccg agcgtatttt cctgataggt ttcaggaact tgtgacatgt 2804401 caatcatctg cacgcctaaa aacggacggt ccaccttccc gttttgcagc agctggtcaa 2804461 caatcggctc gacatcattg cttgggatcg caaatccaag tgattccacg ccgctttcgc 2804521 tcaccttcaa gctgttgatg ccgatgacct ggccgcttgc attgattaat gggcctccgc 2804581 tgttccccgg attgatcgct gcatcggttt gcagcacgtt catttccacc gtcccctgtg 2804641 ttgtatccac atcaattgtc cggttcagtc cgctaatgat accttgtgtc actgtaccgg 2804701 aaaactgctg tccgagcggg ttaccgatag cgattacctt ttcgccagtg cgcagctgtg 2804761 aagagtcacc aaagctcgcc acttttttta cattcttgcc gctgatttcc aaaactgcca 2804821 aatcagtaat ggtatcgctg ccgacaagct tggcagtttc cgtttctccg ttgtatagcg 2804881 taacagtcag cttgttcgcg ccttcaacga catggttgtt tgtaatgata tacgctttat 2804941 cgctgtcttt tttgaaaata acacctgacc cggttccgct ttcactttct gagctggagc 2805001 ctcctcccgt gccgaatgtg ttattttgag aggtttggat atttgagatt ccgacaatcg 2805061 taggctctaa atcctctacc atatcagcga tgtttgatgc gttcgttatc ggcgccgttg 2805121 taaaattatc agactgcacc tgtttatttg cggaagcggt ttcggtcgcc tgattttggt 2805181 ctgacggcag ataaggcgcg atgccaagca tgaggccccc gccgataata ccgcctaaaa 2805241 tcgggctcag ccatgcggct ctccgtttct tttctttttt cacagccgtt tcttgctttt 2805301 ccatttctaa agcagaagcc gtttcctgcc gtcccgcttc atacgacaca ggcgcgtcaa 2805361 gcaattcttg ttcagaatgt ccaatcagct tctggttttc tgtattctgc tgttctgtat 2805421 gtgaaggttc agtttgatgt tgatcgtttt ggccatcacg tcgataatcc atgttcttac 2805481 actcctttaa cggttattca tttatcgtta catattcatc gcatgtacaa gttcaattgt 2805541 cccaataatg aggagaaaag caaagcacca aaatagaata tgtttgatca tcctacatct 2805601 tcctcgctct ttttctcttc ctttcttccc ttaaccatat cataaacaaa cattgtggga 2805661 taaaaatgaa aagaatatgt gaaattatga aaattgcctg ccgtatgtta aaactagttt 2805721 ataatgacgt tgaaaggatg tgaagagcct tgtcatacac catttatcta gttgaagatg 2805781 aggataacct gaatgaactg ctgacgaagt atttagagaa tgagggctgg aacattacat 2805841 cttttacgaa aggtgaagac gccagaaaga aaatgacacc gtctccccac ctatggattc 2805901 tcgatatcat gctgccggat accgacggct atacattaat aaaagaaatc aaggcgaaag 2805961 atcctgacgt gccggtcatt tttatttccg cccgagatgc ggatattgac agagtgcttg 2806021 gcttagagct tggcagcaat gactacattt caaagccgtt tttgccgcgg gagctgatta 2806081 tccgtgtgca aaagctgctg cagctcgtat ataaggaagc tcctcctgtc caaaaaaatg 2806141 aaattgccgt ctcctcgtat cgggtcgctg aagacgcccg cgaggtctat gacgaaaacg 2806201 ggaatatcat caatttgacg tcaaaggaat ttgatctgct gctattattt atccatcata 2806261 aagggcatcc atactctcgt gaggatatcc tcctaaaagt gtggggacat gactacttcg 2806321 gaacagaccg ggtcgttgat gatctcgtcc ggagactgcg cagaaagatg cctgaattga 2806381 aggtggagac gatttacggt ttcggctaca ggatgatgtc atcatgaaaa acaagccgct 2806441 cgcgtttcag atatgggttg tcatatccgg catcctgtta gcgatatcga ttttactgct 2806501 tgtgttattt tcaaacacgc tgcgagattt tttcactaat gaaacgtata cgacgattga 2806561 aaatgagcag catgttctga cagagtaccg cctgccaggt tcgattgaaa ggcgctatta 2806621 cagcgaggaa gcgacggcgc cgacaactgt ccgctccgta cagcacgtgc tccttcctga 2806681 aaatgaagag gcttcttcag acaaggattt aagcattctg tcatcttcat ttatccacaa 2806741 ggtgtacaag ctggctgata agcaggaagc taaaaagaaa cgttacagcg ccgacgtcaa 2806801 tggagagaaa gtgttttttg tcattaaaaa gggactttcc gtcaatggac aatcagcgat 2806861 gatgctctct tacgcgcttg attcttatcg ggacgatttg gcctatacct tgttcaaaca 2806921 gcttctgttt attatagctg tcgtcatttt attaagctgg attccggcta tttggcttgc 2806981 aaagtattta tcaaggcctc ttgtatcatt tgaaaaacac gtcaaacgga tttctgaaca 2807041 ggattgggat gacccagtaa aagtggaccg gaaagatgaa atcggcaaat tgggccatac 2807101 catcgaagag atgcgccaaa agcttgtgca aaaggatgaa acagaaagaa ctctattgca 2807161 aaatatctct catgatttaa aaacgccggt catggtcatc agaggctata cacaatcaat 2807221 taaagacggg atttttccta aaggagacct tgaaaacact gtagatgtta ttgaatgcga 2807281 agctcttaag ctggagaaaa aaataaagga tttattatat ttaacgaagc tggattattt 2807341 agcgaagcaa aaagtgcagc acgacatgtt cagtattgtg gaagtgacag aagaagtcat 2807401 cgaacgattg aagtgggcgc ggaaagaact atcgtgggaa attgatgtag aagaggatat 2807461 tttgatgccg ggcgatccgg agcaatggaa caaactcctc gaaaacattt tggaaaatca 2807521 aatccgctat gctgagacaa aaatagaaat cagcatgaaa caagatgatc gaaatatcgt 2807581 gatcaccatt aaaaatgacg gtccgcatat tgaagatgag atgctctcca gcctctatga 2807641 gccttttaat aaagggaaga aaggcgaatt cggcattggt ctaagcatcg taaaacgaat 2807701 tttaactctt cataaggcat ctatctcaat tgaaaatgac aaaacgggtg taacataccg 2807761 catagcagtg ccaaaataga ctgtagatgt tttgcagtct atttttttat gtgaaagaat 2807821 agccgttaaa atctctgtaa tttgttttga gcggctgttt gcattgatga acccattttt 2807881 tctctgacaa ggtctgcttc ggatatttga ctttctccac tttgattcct ctgtttcgca 2807941 agcggctgat catttcgtcc aattctctca ttctagattc accctttcgc ttgagctttg 2808001 accattcggt catctcaatt tataatataa ataatacatg ataaaaaaac aagttacaat 2808061 aaggttaatt ttataacaga cggtgtgact atatggtcat atcctagcag gcctccgggc 2808121 tccgaaaggg tggaaccatt gaaggaaaaa gaaaaactga ttattgaaac agccttaaaa 2808181 ctatttgccc aaaaaggata caactcaaca tcagtccagg aaatcgcaaa agaatgcaaa 2808241 atatctaaag gcgcttttta tatttatttt ccttcgaaag aagcgcttct tctctctatg 2808301 ctgaactact attatgataa aacgtttacc cgaattttaa atattaaaac gaagggcgac 2808361 agccccagaa cggcttaccg taaacagctg accgtcctct atgaaaacat tcttgaacac 2808421 aaagatttta tcagcatgca gttgaaggag ggttctctgc cttacacaga agaagtggag 2808481 caatgcgcaa aaaaaatccg ccagtcctca cttcaatttc atatcgacag cctgctgaac 2808541 atctatggaa aaaaagcgga accgtacact gctgagcttt gttttttaat agagggcatc 2808601 agccagattt acctggaatg catgattttg ctcgggtaca ctgtgaagcc gtctcaatta 2808661 gctgatatca ttatgaatcg aattgatgat atggtaaaag gcatgtctga acgaaacgat 2808721 aagcctttca tcacattgga agaggcgagc tctttattcg gacctcttac gcacggacgg 2808781 cctgacccgc tgactgaatc aattgtgaaa agcctacgtg acaaaattaa cagcttaaac 2808841 acaaactcct ctcttgaatt atcggagagc ttggacatac ttgaagcaga aatgaagaaa 2808901 aaaacaccga agctggcgat cataaaagga atgattcata atctgacgga gtctgaagct 2808961 ctcgccaaag atgcggaaca gcttaaatat ttattaaaac agcaacatat ttagaagaac 2809021 ggctgcttaa aaagcagccg ttcttcctat tacgcctttg gttttaccat gtcttccggc 2809081 ttaaccattt cgttaaattg ctcctctgtc agcaattcaa gcttcaaagc tgcttctttg 2809141 agcgtcaatc cctctttatg ggcaagcttg gcgattttcg ccgcgttttc ataaccgata 2809201 tgcgggttca gcgccgtaac aagcattaat gaatttgaca ggttttcctg aatggtttct 2809261 ttattaggct caataccgac agcacattta tcatggaatg aattcatgcc gtcactgagc 2809321 agctgcacag attgcaggaa gttgtaaata ataacaggct taaacacgtt cagttcaaag 2809381 ttcccctgac tcgccgcaaa gccgattgtc gcatcgttcc ccatgatttg cgctgcgatc 2809441 attgttaacg cttcgctttg tgtcggattg actttaccag gcataataga gcttcccggc 2809501 tcattttcag gaatgacgat ctccccgatg ccgcagcggg gtccgcttgc gagccatctg 2809561 acatcgttcg cgattttcat taagtcagcc gcaagcgctt ttaatgcgcc atgcgcataa 2809621 gtgatttcgt catggcttgt cagcgcgtgg aatttattcg gcgagctgct gaacgtttgg 2809681 ccggtcagct tagtgatctc ttctgagaca agctctccaa actctgggtg ggcgttgata 2809741 cccgttccga cagccgttcc accaattgca agcgcacgca ttttatctgt cgcttccaaa 2809801 atcatttcct tcgaacggtc cagcatgtga acccatccgc tgatttcctg tccgagggtc 2809861 agtggcgtag catcctgaag atgcgtgcgt ccgattttga caatatcatt gtatgctttt 2809921 gctttttcat ccagtgtatt gcgaagctga tcaagcgccg gcacaagctg ctcgtaaaca 2809981 gccaaaacag cggcaacatg catcgcagtc gggaatgtgt cgtttgagct ttggcttcgg 2810041 ttcacgtcat catttggatg aatcgtttga tcagagttct tctcttttaa taaagcagtc 2810101 gcacggttgg ctaccacttc gttcatgttc atattgcttt gtgtgccgct tccggtctgc 2810161 catacgacaa gcgggaagtt gtcatcgtac ttgcctttga gcacatcatc acaaaccgct 2810221 gcaatcgctt ctgctttttc agcgtccaga ttgccgaggc gtttattagc tagagcagtg 2810281 cttcgtttta aaattgcaaa cgccttcaca acacgcatcg gcattttttc agaaccgatc 2810341 ttaaagttct ccttgcttcg ctgtgtttgg gcgccccaaa atttatcagc aggaactttt 2810401 acttctccca tggtgtctcg ttcaattctg tattccattt atgtatccct ccataacggt 2810461 tgcttcaata gatcataatt cgccaatgac acaaaaaatc ctttttattt ttcgatcttg 2810521 gcagatttta attttaattc aagatatacg cgggaatcct ttgaatattt gtattttgga 2810581 tttgtcctgc cgtactcctt tgatgtataa gagacatcat aatgctgttc aaatgatcta 2810641 atgagctgtt caatttcttc ttgttttcca gctagcctta cctgtgccac ttcgtatcct 2810701 ccgctttcat aaaaaaactt actccatgaa atactctaac acagtatatc atttttttaa 2810761 caggaaaaga taacctctac taaggttttg gataagaggt gacctcattg gaacaaacag 2810821 agtttaagga atatatacac gataatttag cattggtgct gccaaaatta aaagaaaacg 2810881 atgatctggt gaaaaacaaa aaaatgcttg cgaacggact ggttttttac tatctctatt 2810941 tcagtgaaat gactgatgag aataaggtgt cagaagccat taaaactttg attaaagatg 2811001 aggagacctt aacgcttgac caggtcaaaa aacgccttga ccagcttgac gcaagacctg 2811061 ttgaaactgc aaaaaaaacg attgaatcga ttctcaacgg caattgtgct gtgtttatca 2811121 acggattgga taaagcctat attctgacca caggaaagaa aaaaacaaga agcctgacag 2811181 agccgacaac tgaaaaagtg gttcgcggcc caaaagtagc gtttgtagag gatattgata 2811241 caaatctcgc tctgatcaga caaagaacct ctcatccgaa attgatcacc aaaaaaatca 2811301 tgatcggcga aaacaagctg aagcctgcag ccattatgta cattgaaggc aaagcaaaaa 2811361 agtccgtcat aaaagaagtg aaggcgcggc ttaaaaatat ccagctggaa gatatccagg 2811421 acagcggaac gctcgaggag ctcattgaag ataataaata ttcaccattt ccgcagatac 2811481 aaaatacgga aagacctgac aaagtatctt cagccctgtt taacggccgt gtggcaattt 2811541 tggtcgacag ttcaccattt gtgctgctgg tgccggtttc tctcggcatc ctgatgcaat 2811601 ccccggatga ctactatgaa cgctggattt cagcatctct tatccggtcg ctgcgctttg 2811661 cttctatctt tatcaccttg tttttgtcat cgatttatat aacacttgtt tccttccatc 2811721 aggggctgct gccgaccgca ctcgccgtca cgatttcggc gaacagggaa aacgtgccgt 2811781 tccctccgat atttgaagcc ctgctgatgg aagtcaccat cgagctgcta agggaagccg 2811841 gactgcgact ccccaatccg ctcggacaga cgatcggcct cgttgggggc gtagtcatcg 2811901 gacaggctgc tgtagaagcg aatctcgtca gttcgatttt ggtcattgtc gtcagtgtca 2811961 ttgccctggc atcctttacc gttcctcaat acggaatggg tctgtctttc cgggtgctgc 2812021 gttttatttc gatgttttcc gccgctattt tagggctata cggcattatt ttatttatgc 2812081 ttgtcgttta tacgcactta acgagacaaa cgagctttgg gtctccgtat ttttcgccaa 2812141 acggattctt tagcctgaaa aatacggatg actccattat ccgtctccca attaaaaaca 2812201 aaccaaaaga ggtgaataat ccaaatgagc caaaaacaga ctccactgaa acttaatacc 2812261 tttcaaggta tttctattgt tgcaaataca atgcttgggg ccggactttt aacattgccg 2812321 cgagcgctga ccactaaggc taatacgcct gacggctgga tcacgctgat attagaaggt 2812381 ttcattttta ttttcttcat ttatttaaac acgctcattc agaaaaaaca tcaataccct 2812441 tcactctttg aatatttgaa ggaagggctt gggaaatgga tcggcagcat catcggcctt 2812501 ttgatctgcg gctatttcct cggcgtagcc agcttcgaga cacgggcaat ggctgaaatg 2812561 gtgaagtttt tcctgctgga gagaacccca attcaagtca ttattttaac gtttatttgc 2812621 tgcggcattt atttaatggt tgggggctta agcgatgtgt cgcggctgtt tcccttttat 2812681 ttaacggtaa ccattattat tttgctgatt gtgttcggga tcagttttaa aatttttgat 2812741 atcaataatt tgcgtcctgt tttaggcgaa ggccttggac ccattgcaaa ctcccttacc 2812801 gtcgtttcca tctctttttt aggaatggaa gtgatgctgt ttcttcctga acatatgaag 2812861 aaaaagaaat acacgttcag atatgcgtct ctaggatttc tgattccgat tatcttatat 2812921 atccttacgt atattatcgt tgtcggagct ttgaccgctc ccgaggtgaa aacgctgatt 2812981 tggccgacta tttctctctt tcagtccttt gagcttaaag gcatatttat tgaacggttt 2813041 gaatcctttt tactggtggt ctggattatc cagtttttca ccacatttgt catttacgga 2813101 tactttgccg ctaacgggct aaagaagaca tttggattat cgactaaaac aagcatggtg 2813161 attatcggca taacggtctt ttatttttct ctctggccgg atgacgccaa tcaagtcatg 2813221 atgtatagcg attatcttgg ctatattttt gtctccctgt ttctgcttcc gttcattctc 2813281 tttttcattg tagctctcaa gaggaggatt acaacaaaat gaaaatccgg attttatgta 2813341 tgtttatatg caccctattg ctgtccggat gctgggacag tgagaatatc gaggaattaa 2813401 gcttagtgat cggaataggg ctagacaagc ctgacgatga aaatttagag ctgacacagc 2813461 aaattctcgt gccgaaaata atcagcgcca aggagggctc ttcatctgat ccgacacagc 2813521 tttctatcac aaagggtaaa actgtccatc aaatgatgag aacctctgca ttaaagcata 2813581 agcctacgtt ttcacagcat ttgcgtctca ttctgctttc caaaagcgtg attgcggatc 2813641 aaattggaat ggacgccatt attaaccagt ttgtcagaga caacggaaca aggaggagtt 2813701 cctacgtctt tatcaccaac ggccgaacta aggatatatt taacatgaat gatgaaggcg 2813761 aacccgcatc caacgtgata tatgatctga cagagaataa taaggtgacg atcagaacga 2813821 tggagccagt tacattgggg gagatctcag aacacttaac ctctgacgat tcattcctca 2813881 tccctcatgt cggtaaggaa aacggcaagc tcgcgataaa cggagcctct atcataaaaa 2813941 ataaattatg gcaccgggac ctcaccccga ttgaggttca aaatatcagc ttattttcag 2814001 gcactgtcga gggaggcgtc attgacttga agcgcgatgg ccatctcttt tcttatgaag 2814061 tatattcaag caatcggaag atcaagacgg catacaagga cggaaagttc aaattcaccg 2814121 ttacccgcaa tattgaaggt cgtctatctg aggactggaa tcccaatgaa gactcgttta 2814181 aggattcata tattaaaagt attgaaaaga cagtcgaaaa acgagtacac gaaacagtaa 2814241 cgtcatttat tacagagaag ctgcagaaag agatcaaagc ggacgtaacc gggctgggaa 2814301 acgaggtcag aattcattat cctcaaaagt ggaaaaagat ttcaagaaaa tgggatgatg 2814361 attatttcag caatgcggaa atagactacc gggtcaatgt gattgtcaga gacttcggaa 2814421 cgaaaggcgc aaacaaatag cagccgccta attcacgaga tgatttcggt gtgcgtacac 2814481 cgccgcctgc gtccggtcac tgacatccag ctttgataaa atattcgtaa tatgtgtttt 2814541 gactgtttta atcgtaataa acagttcctc gcctatttct ttgtttgtct ttccttctgc 2814601 gatcaggcag agtatttcga gctcccgttt tgtaagcgat tcatgcggga gcgcgttttc 2814661 acctgagtgg cgcagcctgg ataatacttt tcccgccact tttgactcca gcttcggctc 2814721 tcccttgctt gcggcgcgga tggcatcggc gatttctgcc gcttttgagg ttttcaacag 2814781 atagctgagc gcgccagctt caataaccgg gtacactttg tcatcatcaa tgaagctagt 2814841 gagcacaata attttcgggt cggaaagctc ccggcaaatt tgctttgtag cttcaatgcc 2814901 atccatgccc tccatgacaa ggtccattaa aatgacatca ggcgacagtt ccacagcaag 2814961 ccgaacacct tcgctgccgt ccgatgcttc gccgatgact tcaatatcgg gctgcgcctc 2815021 caaaaaagcc gcgagcccca ttctgaccat ttcatgatca tcaatcaata atactcgaat 2815081 cacgttcgtt ctctcctttt tcttccggaa aaatcgggac cttcacttcg atttgagtgc 2815141 cttttccttc tactgaaatc acttcggcga caccgccgat ttcacttgca cgttctttca 2815201 tagaattcaa gccgtatgag gaggctttca cctggtccat tttaaagcct tttccattat 2815261 caatcacctt cagacggagc tggctgttct ttatgcccag aatcacggtt acttttgacg 2815321 cttttgaatg tctaaatacg tttgaaaggg cctcctgcac gattctgaac aagtggtctt 2815381 caacaccctt ggatatcgct gtgtcctgta tatcccactc aatatcaatc ggctgctttt 2815441 ttcggaactc gtccaaaagc tccgtaaggc cctccttcag cccttttcct tcaagggtaa 2815501 caggccgtaa atggagcagc agcgccctca tctcattttg ggcttcgcct gccatatgct 2815561 cgaccatcct gatccgcttg actgttttgt catcagcatc cttgacatgt tccagcacgg 2815621 ctgatgtcat catcgatatg gcaaagagct gctggctgac cgcatcatga agatctctgg 2815681 ccaatcgctg gcgttcttct gagataaccg acttcttcat ttgagcctgc cattccgcac 2815741 gttcattgga aagtttctgg agggatgcga cttgaagctc cacgcgcttc gccatttcgt 2815801 tcagctgatc agcagccagg ccgatttcat catcaccgag cggcggtatc cgataagcga 2815861 aattgccgtt ttcaaaggtt aaaatggatt caattaatgt atcaatcctt gtcttcaacc 2815921 ggttgccgta catataccct gaggcgaaac cgacggtcac gctgatcaga agcaaaatca 2815981 ggataaacgg aattccgaac cagcttgatg acagcaaaac aagcggatcg agccgatagt 2816041 aaaacatcat aaaggaaatc aggcaaacaa aaaggagcag gctgattccc gttgtcatgc 2816101 ggatggcgcg ccattggagg ctggcaagca ttttttttct catacgtact tcacatccac 2816161 atcaccgata aataaggaaa cggacacttt tacccggcgc tttgactcgc taaaatcagt 2816221 tgacgcggca tataccttcg tgcttaatcc gcttttcttc gagccgatca gattaatgtc 2816281 tcctataaaa acagccgagc tgacagccac ttcaaggtcc gatggtacat aaatatcaac 2816341 gttaccaatg actccgctaa tgacgattgt actttctccc tcgggaatca tcgctttaga 2816401 taaatcgatt ttgatatcac cgataaaacc agagacattt aaatcgttca ggtcaaacgg 2816461 ctgcttcatc atttgcagct caccgataaa aaagctgcgc atgtcgggat gttttacatc 2816521 ttttggcggc tcatgatgtt cttttttatt gagattgacc tgtttctcat tcggttcaaa 2816581 tatcggcttc cctttgataa gcctgtagcc ggcgtaaatc agaaatgcgg caaacgcata 2816641 gccgaataaa ttaaaggtga tgctgaagag gtttttcaaa aatagaaacg cggcaaagat 2816701 atacatgacg gagccaagcc aatcacggga atatttttta aggaaatagc cggcaatcag 2816761 aaaaaagagc ggccaaaaca gcagatcgcc tattccgata atttgcaaaa acatactgat 2816821 gccgaataaa gcaatgatca atccgagaag ctgttttttt gtcattcctg gtgtccgcct 2816881 cctttcttct gcctagtgct accgtatcgc tagatccccg ctgtccgttt tgatgtcgat 2816941 tggatgccgg ccgcttcctt gcgtgcctgt gatgtgatgc tgttctttat gtcctttatc 2817001 agcaaatgaa tacggcgaac tgacgtcacc gcttgctgat aaagcattga ctgcaaagct 2817061 gccattttgg ggaaggctta cattagcatc accgcttgtc agcgtgacag atacgggacc 2817121 ggttaccttt ttcaatacag cattaaaatc tcctgaagtc attttcacat caagagagcc 2817181 tgatacatga accagatttg cgtcccctga agctaaatca atgccggctg ttttggagac 2817241 ggtatttgaa atggaaacat cccccgatga tgccttcact ttcagatctt gaatgcggac 2817301 gtccgtcacg ctcgtatttc cgctcgcaga tactgcgttc agcccggaaa gcgcaagatg 2817361 gtcattcccg gccacagaca cgtcaccgct tgaggttcgt actgccagat cacctttata 2817421 atcatacgga agcctgacga taagagttga acggttaaat ccattcaaaa attgaaattc 2817481 tttttccttt acggtcagct ccagttttct tttgttttca gtaacaaata actttcctga 2817541 gtctcctgaa atgcctgccg atatgtcact tcgttcttcc gctataatcc ggacatcctt 2817601 gctatccgac tcaatgacca tgctgtcaat gtcccgcggc gatgcgctgg ctgaatcagc 2817661 ttctgtgcca tttatgaaac ctaggcctgc agcaaacaca tcttttacga cgacggcgaa 2817721 aaaaaccaga ataccggcag tgatcaacag tttgccaagc atttttttca ttcggtttca 2817781 tccttctcat tcattctatt ataaaggaaa agcttgcgaa ttgatacgtg cggaagggaa 2817841 ggacttgacc gcaaatcctt ccccgttccg cttattcatt tgccgctttt gtctggtctg 2817901 atttttgcag tgaaagtgtc cgcatttttt caatctccgc ttccacatcg tctgcgaatt 2817961 ctttacgtgt aagttctgtg ccggcttccg ctgactttga ataattcgcg cggatttcca 2818021 tttcttcaat acgattttca atacgtaaaa attcacgata cgcgctttca ctgtcaattt 2818081 tgtcaaatgt cgtattcata tgctctttag ctttcgccgc atttgcccgc gcaatcagcg 2818141 cctgtttttt atcctttacg tcctgaagct ttgtttcaag tgcagccagc tgctctttca 2818201 gatcagccag ctgactgttt gcctgttcat aggaagcttt atgctcagcc gccttccctt 2818261 ctaaatactt catttcagtc agcgcctttt tcgccagttc ttcttcacct gcgtcaaatg 2818321 cgagctgtgc ctgatttttc cgtttgccag ccacttcagc ggcttcttca tattttttct 2818381 taaattgata ggcaatcgtg tgctgtttca caattgtttg ctttgctttt gcgatgtcgc 2818441 tttccatatc gcgtacatat tgattcagca tcacctttgg attctccatt ttatcaagtc 2818501 cttcatgaac tgacgcaaca aacatgtctc tgattctttt taataccata cctgattcct 2818561 cctaatatat tgatattatt ttttcttcaa aaattcttcc cattcgtcat caaagtgaga 2818621 ttggtaggca gcagaagccg gttcaggatc aaaagatgat acaccgttat cagctgatcc 2818681 gtttttcatc agcttccagc cgtaatacac catagcggcc gccaatgcga ttccgacgac 2818741 aaacggaagt gagcagatga gcataatggc tccgataccg cccacgatga ttcccgtgat 2818801 ggtttttccc gcggcaaacc ttttgattcc tgcgtatgtc atcaagctcc cgatggcgag 2818861 cgggatgata aagccgaagc ttcctcctcc aaaaaagacg gagatcccaa atacaattaa 2818921 taagaatccg cctattgttt tcttgtttat tttcatgcag atcctccttt cgttttcctt 2818981 gtcttcatct tatacaagtt ggaagatatg caaaacgaat cagagattga tttttatata 2819041 agaccggagt cgtatctcgc accggaccca ttggcacaaa aaaacgccat gcacgaggca 2819101 tggcgtttta aaacccttta cagatgaaca cttgcttccc tttctttaat taggtcggac 2819161 ctttctgctt tggccaattt tgtaaacagc aagattccga tacccgcaat aatttcgaca 2819221 atcccaccga cagcgatcac tttacctgag ccgaaagcat tagcggcata cccgcaaatg 2819281 acagctccgg cagggatcga aatatttgag atcatatgta taacggcgta aacctgcggc 2819341 tgatcctcac tatccacaga cgtctggata atcgtgtact caggaacatt aacagcactg 2819401 actgcggcac caaaggtaaa agcagcgaaa aagacgagcg gcaaaaaggt attcatcccg 2819461 gtaataaaga aagcaaatcc ttcaataatg ccggcagtga cgaataacaa gccgtacctg 2819521 tttaccttga ctttcgccag cacaaaccct aataaaaacg cgcccgcggc ggtggtggcc 2819581 tttaaaagcg agtatacgat cggctggccg tttaaatctt ccgcaacgta tacggcagag 2819641 agcgcttccc atggggcagc cgcgaaattc ataaagatac agtaaatggc gagcggatat 2819701 aaaatctggt gttttctgac gagcctaaag ccgcgtttca gtcttccgat atatgtgcct 2819761 ctctgtgtaa caaccgcaga ctctgattga gattcaaccg cagtgtactt aataaaaaga 2819821 acgagaaaac ctgacaccaa atagagcaca agtgcgataa gcatggtata agaaggacta 2819881 ataaatgtaa gaaaagcgcc gcataatgtg acagccccaa gccggacaat ttgagcggag 2819941 gattgcagca cagcgtttgc tttttgaatg ccctgttcat tgacgatttg aggaatcaaa 2820001 gcgatagagg cgggattgta ggcagctcca gtagctgaat gcacaatcat aagcgtcatg 2820061 acaaaccaca gcggagagaa gcccgcaaaa tgacatagag ggataatcaa aacaatcgcc 2820121 gcccttgtca gatctgaaaa gtacatccaa aatttcagcg tggtctgttt cataaaaggc 2820181 cccgtcacag gcgccagaac ggcttccggc aaaaacgtga cagcaatcaa taaagcagtg 2820241 ccgatcgcac ctttgccgtc ataaattaaa aaccataata ttgaattaaa tgcgaacata 2820301 tcgccggata tcttgactat tcttgagaaa aacagataat tgaaatttct cttccagatg 2820361 ctatcacttt caattaaatt caccatccat cagagccccc cgttgcctat tttttacatc 2820421 tatttattac aatatctcat ttttccattt ttcagtcaat aattcataag gttcattttt 2820481 tgtcgtaaaa tgggaaattg acagagtgaa aaacaaaaaa agccggcatg tatttgaaca 2820541 cgccggcttt ccttttcact ttttatgatt cgctgctgtt tcggtcccga aacacaatgg 2820601 cacttctttc atattctaca tcgccaatac cgcttcttgc attcacaacc cgggcggcgg 2820661 caaagaaata atcggacaga cgattgagat aacgcagcac tgtttcatga atctcctccg 2820721 atttcatcag cgccaccact cttcgttctg cccgccttgt aatggtgcgt gcgatatgga 2820781 gaagcgaagc acactttgat ccgcctggaa gaataaattt cttcagttcc ggcgcttctg 2820841 ctgtataggc atcaatgcgc gtttctaaaa aggaaacaga ttcttccgtt agtttatagt 2820901 cttttctttc tgtgacgatt gccagatcgc ctccgcagtc aaacagctca tgctggatgg 2820961 tcagcagctc ggctgtcaga tcttcaaagc cgggctgccc ggaaagctct gccaaagcaa 2821021 gcccgataaa gctgttaagc tcgtcaatcg tgccgtagct ttcgacgcgt aggctgtcct 2821081 tgtccgttct gcccccgact aagcccgttt gtcccttatc gcctgttttt gtatatagtt 2821141 tcataccctg aatctccttt acagacttat tcaaacaact cagcagcctc ttttatacat 2821201 tcagctgtcc ctttctttat caattggttc agccgctgtt ctatgttttc tgattgctga 2821261 gtttgagtcg cggcgatgag aatatcacct gtgcctcctc cgtctcccag cactttcgtc 2821321 cgttctgctt cggcagccat aagagctttg atgaagaatt gatctgccgc atagccgtta 2821381 atcaaaatcc aaatcgaaaa gccggtctga acgcatatga aaacggataa ctctccgtct 2821441 tcatatgttc gatacacgaa acggtcaagt ctttctgaag aagccatcgc acacgtctcc 2821501 tgcagttgaa aaccgctttc tgaaagacag gccgtaagtc cttctatcgg atctggctga 2821561 tctggcagcc gtttatggat cagcgtcctg ctccacgaaa accctgcacc gataggcgtg 2821621 gaggacaatg ttcgaagcgg gatttccgtt tgcagaagaa tgtcatcacg ccccgcttgg 2821681 agcaatgctt caaatgggat agactgccgc ttcacgctat ctttttcagg ctgaatcaca 2821741 atcatcggtt taggtgagct ttgatgaacc aaggcggtga catctgtatc gtacaccgcc 2821801 tttatgcttt gttctgtaac agcatattcc ggtttttgct taggcccggc ggtaccgttt 2821861 ttcataaaca tgagcccatc acagtacagg cttgcggtgt tcagatcatg aaaaacgctg 2821921 acagctgcca atccgctttc tctcgtcagg cgtttgatca gatcaagcag gtctttttga 2821981 taagccagat cgagaaaatt agtcggctcg tccaaaaata aaatacgcgg ctgctgcgcc 2822041 aaagcttgtg ccaaatacac ccgctgctgt tcccctccgc ttagttcgcg aatcggcttt 2822101 tgcgcaaaat cggccactcc tgtttgctcc attgcttcct gtacaatggc ttcacccttt 2822161 tcagtctgct gtctgaacag ccccgtttgg aatggatatc tgccaaaggc tacagtttct 2822221 tcgacagtaa aggtgaaggc ttgatccatt ttttgcggca ggacagccat gatttgcgcc 2822281 agttccttcg gtttatagtc cgccagcagt tttccggcca gataaaccct gcctttcttg 2822341 gccggcagcg tacctgtcag caagtgcaaa agcgtggttt ttccgcttcc attagggccg 2822401 agaattccaa gaaattctcc cttctccact gttaagctga cattgttgat taggcggctg 2822461 tcgccgtatc ctcccgacag cccttctgcc ttcatcataa gcttctcccc ccgcgatgct 2822521 gccgaattaa aataagagcg aacacaggcg ctcccgccaa ggacgtaatg atcccgatcg 2822581 gcagttcaat cggctcaatg atggttctgg aaagcagatc ggctaaaaca agaaaccctg 2822641 ccccaagcaa ggcggacaac ggcagtaaat gccgatggtc cgttccccac aaaagccttg 2822701 tgatatgcgg aatcacaagg ccgacaaagc caatcgtacc cgatactgcc acagcgcttc 2822761 ccgtcaaaag agatccggct attaaaatca tcatcttcct ctgctgaacg ctgactccaa 2822821 gaagctttgc tttatcttct ccatatgtca tcacgttcag ttcccttccg tttataatca 2822881 ataaaatggt tcccaaaaga aaaaacggga gaaacaaaat aacatagctc cagcccctca 2822941 ttgagacgct gccaagcagc caatgcacaa tcggaagcag gttgtctcct gtcaaggcga 2823001 tgataagaga aataaatgcg cctaaaaaag agttggtgat gacaccggtc aaaatgaggg 2823061 tggaaacaga catcgaagca tgaacgaggc ggctgaagaa aaggaccgcc gccatcgtgg 2823121 ccagtgccgc ggctacactc aaaaccggga gtgtaaaccc tccgatgaca ggaaggtgca 2823181 aacctaagaa cagagtcaca acagctccga ctgaagcacc ggatgacaca cctagcgtat 2823241 agggatcagc aagcggattt ttcaacaatc cttgaaaagc ggcccctgca atagaaagag 2823301 ccgcccccac aagggcggcc agcacaactc tcggcagtct gatattcatc ataatattag 2823361 tgtacatcgg atcatcagaa ccgatagagc cgccgaaacc ttgatgccaa aagacacgaa 2823421 aaacagcggg aataggaata tgcaggctgc cgcaagaaat tcctaagatg atgctcacgg 2823481 ctaaaaatga gaaaccaatg atatatgcgg cataacgatt attccttaaa cgtatccggg 2823541 taaatgcttt ccgcaagttc ttcgacccct tcgatcagac ggggaccgga acgtgtcaca 2823601 agatcagggt ccacatcata tacacgatga tgtttcacag cattgatttc gctccagcca 2823661 tcgcgttttt ccacagcttt cgctttcaca ccgtccgttg taacaattgc atcaggattg 2823721 agttttacga tcgcctcgtc tgtcatttgc acccatcctg tctgatccgc agctgcgttt 2823781 ttagcatgga tgacatttag catttcattc ataaacgtat cttttccggt tgtataaatg 2823841 tcaggatcag gagaaacctc gataaatacg cttttctcct cgtcttttga aatggttttc 2823901 gctttttctt gaatatcctt tagatctgat ttcatgcttt tcacgagctg atcggctttt 2823961 ttctccgccc cgccagcttc tccgatcatt tcgattgatt tgtacacctc ggagaatgat 2824021 tgtgcatcat tgacagtcag cactgtaatg cccgcgtcct tcagctgttt gatggcatcc 2824081 gctgatgctg acatggaaga ctcatgggcc agaacgagat ctggttttag agaaatgact 2824141 ttttcaacgt ttacattcat atctccgact ttctcaacct ttttgacttc ctttggatag 2824201 gtatcgtttg tggtgacacc gaccactttg tcaccaaggc cgagtgcgta tgtaatttct 2824261 gtgttgctcg gcattaatga aacaatcttt tttggctctt ttttgatggt tacatcttgg 2824321 tttgacgcat catcaatggt gacagggaac acttctgttt tttgttttgc ctttgaatcc 2824381 ttctgatccg caggattgcc gcagcctgcc agcataacag cagccaacag aagcgcagcc 2824441 catatcccgg ctcgtttttt cataatcttt tcctcctaaa cgaactaaaa aagcatctct 2824501 acgacggtaa agatgctgta aacaacacaa aaaagcctat tgtttacaca tcatctgtcc 2824561 tcgcagaatt cgtgctgatc aaacaggcag gtatcctggc tcttggcgct tggccaatta 2824621 cagtggcggg accgcaccgg cttttaccgg tttccctttt aagccggctg ttgttcacgg 2824681 accggcacct atttgacatt cgtatccgtt tttcggagta attatactat atgactgaca 2824741 ggcttgtata tgtgtcctga atgacttttc cccatattgt gtatggaagc aaaatcctcg 2824801 taaacactaa atttgatctt gtatacttaa taccatcatc tatcaaaagg aatgattctt 2824861 atggatttac agctaaaaga aaaactcgtc ttaatcaccg gctcgacgtc cggtatcggg 2824921 aaagccgccg caaaaagctt tctgcaagag ggtgcggcag tcattgtcaa cggacgcaaa 2824981 caggagactg tcgatcgcac cattgaagag ctttctggct atggaacagt gcacggtgct 2825041 gctgccgatt tgtcaaaaac agatgaagca gcggctttta tcgaaaaagt aaatgaaatc 2825101 ggtgatatcg atatccttgt caacaacctt ggtttcttcg aggtaaaaga cttcgccgat 2825161 gtgacagatg aagagtggaa tcaatatttc gaagtgaacg tgatgagcgc cgttcggaca 2825221 agccgtcact tccttccaaa aatgcttgcc aaaaacagcg gccgcatttt aaatattgca 2825281 agtgaagcag gcgtcaaacc gctgccaacg atgattccat actcaatgac aaaaacggca 2825341 ctgatcagcc tttcaagagg aatggctgaa atgacaaaag gcacaaatgt gacggtcaac 2825401 tcagtgctcc cgggacctac ttggacagag ggcgtggcct cctatatgga aggcgccgca 2825461 caagcagccg gacaggatac agatacattt atcaaagact atttcaaggt caatgagcca 2825521 acctcactta ttcagcgata cgcgacagca gaagaagtcg ccaacacaat cgtattcctc 2825581 gcgtctgacg ccgcatccgc cattaacggc acggcacagc gtgtggaagg cggcattatc 2825641 cgttctctgt agtataaaaa aacgcatccg tgtttcggat gcgttttttt tatacgtctc 2825701 cagcaaatgg taccggctga tatccgcctg tttccagttg tgctgaaaac aaccctccag 2825761 cgtgaggctg ctcgtatctc tctttttctg tcatttgttc tgttgccgtt gtaatgtaaa 2825821 gggtttttaa gtctctgccg ccgaacgcgc agcacgtgac atatttagcc ggcacgctga 2825881 ttgaattgat ttcttttttc tgaaacgggt caatgtgaac aacgcggctg ccgccaaaca 2825941 gcgccaccca cagcatgcca ttttggtcaa ttgtcatgcc gtccggcaat ccgtctgact 2826001 gatcaaaacg atagacaggt tctggattcg aaacatctcc gctttgagga tcatagctgt 2826061 aacgtacaat ctcctgggtc ggcgtgtcga tgtaatacat caaattccgc tcgcggtccc 2826121 aatccaaacc gtttgaggtg gagacttgat ccttgatttt gacaagactg ccgtctagat 2826181 tcaaacggta cagcgacgcc tgtttttgct cgccttccat gctcgtcgtc cccgcccaaa 2826241 gccttccgta cgggtcacat ttagcatcat taaatctcag gctctcatgc atgtccttcg 2826301 gctgtttaat tttttccaag ctgtcatccc gaagatgata caggtaaaac ccgtccttca 2826361 tcgtcataat cagttcatcc tttgaatatt tcgcaagcgc cgtcacaaag gatttgaatt 2826421 tgattgatcg gttgattttt tcttcagggt caaagatgtg gagctcgctc cccaggatat 2826481 caacccaata taagcggccg ttctcttcat cccataacgg gccttcacca atcactgccc 2826541 gagtgtctgc ttccaatact gcatccatgt gttacacctc tttagcttca gtctatatat 2826601 tgttattccc ggcaaagagg tgtccaaacc acttgatgtt tattgttttt taaaaaggat 2826661 ggtaatgacc gttccaatgt tcgttctgct gttcacatgg atcgttccgt tatgcagatg 2826721 gacaagctcc ttggcaatcg cgagcccgag acccgttccg gcagttgaat cttttgtgtt 2826781 cgtccctctg tagtagcggt taaacaaatg ggtgatcgtt tcttcatcca ttcctttccc 2826841 attgtccttc acttttaaag aaatatgatt ttttgtttgc tccagaatga cttgaatctc 2826901 tgttcctttg ccgttgtgct tcacggcatt cccaaggagg ttttctaata tgcgcctgaa 2826961 ccacgcttca tcaagggcaa attcaatatg ctcttctttg gatacaaacg agatatcata 2827021 gccttcagaa aacggatttt tcttaaaatc ctcaatgaca tttttaaaaa acgggataag 2827081 gctagtgagc tttctctcaa taggaagagc atcatttttc aggcgatacg ttaaatttaa 2827141 gtcttcaatc agcttagaca tgtattcaga tttttctctg acaacctgcc ccatttcttt 2827201 cacttcttcc ggcgaccagt catactgctt cgactcgagc atcatgctgt agccgtaaat 2827261 gctgctgagc ggtgttttta agtcatgtga caaaccggca atccattctt cccttgtcgc 2827321 ctggattttt tctctgtttc ttttatccct tctcagcgtt tcagtcagct gatccattga 2827381 ttcaaatatc tcaccgaaga agcggtacgg ctgtttgatt tttccctttt tatttttgct 2827441 gacaggacgg ccttcccggt ttctgggctc ctcaagcttc ccttttgaca gattgaccag 2827501 ccatctaatc gtgtgaaaaa tcggcagccc gaatcggaac atataccaaa cggtcatcca 2827561 aatgatatac atgaacaaaa cggccatcac gagaaacatc gcttttaata caaccttcag 2827621 gaatgatttg ttaaactcct gatcggttac atagactggg ttcggcaccg tagcgaccat 2827681 ccatctgtct ttattgagga tcttaacgga aatttcccgc ttatagttcc aaggcttaga 2827741 gctgtattta agcagctcca gctggttcat cgtttttctc tcgctttttg tgctgttgat 2827801 gctgtcgaga atctttccat tgctgtctaa caggtaaatg gcgccttttt tccgtttaat 2827861 atagtcgatg gtactagact tatagtgcgc tagtgagtct atcttttgtt cacgcttttc 2827921 aacggaagtc aggagctgtt cactttttga tttccagccg gacaatagaa gatacgactt 2827981 atcttcaata ttgatggccc aataattcag tttatagtta tgaagctttt tggttttata 2828041 aatagacaaa agctctttct tggtataggt gcccggcacg tcttttggca cgccgtagga 2828101 ataatcagtg tttccttccg aatcaatgat ttgcatccag ccgtgctgtt tatcaacaga 2828161 tttcttcagg aaattatcca cttcccatgt cccgtcttcg tttacatcga gatatgcctc 2828221 aagtgtgtcg gtcgttgctt tcgtcagccc tgaattggat tccgcatcgc taaaacgggc 2828281 gtctaaatag aaaaacgatg caacaagcat aaccgtaagc agcaggatca caatcagcat 2828341 ctggccgaaa aagtgaaaca aaaacttcca tcttaacctc atgaccgctt gccttcagga 2828401 tttgggataa aacgatagcc gagacctcga acggttacaa tatactccgg attgctcgga 2828461 tcgcgctcaa tcttctccct aagcttgcga atatgaacca tgacggtgtt gttgtcaccg 2828521 taggaaggat agccccatac tttttcatat atttgatctt tggaaagcac cacgttaggg 2828581 tgttcacaaa aatactgcaa aagctgcaga agctgggctg aacaggcaac ggcttccccg 2828641 cctacgatca actcggcatt ttgcggagaa aaagtaaagt aatcatatgt gtaggtttga 2828701 tttgaactcg tttctttcga ttgatatgta cgcttgagat gcgctctgat ccgcgccgct 2828761 aattccagcg gattaaatgg ttttgtgata tagtcatcag ctccaaccgc aaagcccgat 2828821 aatttgtccg cgtcggatga tcttgccgtc aggaaaaaaa tcggagcgtc tgaatactct 2828881 ctgatcaatg tgcaggcttc aaaaccggac attccgccca tcatgacatc cagcacaatc 2828941 aagtcaacct tattggcctt cacaacggga atcgcttctt ctgcgcttgc cgcatccagt 2829001 atatttcgat aaccttcttt ttcgagaacg cgtttgatca tgtccacaat cgctttctca 2829061 tcgtctacga ttaaaattga cgcattttcc acttttatgt tcctttctgt cactgttttt 2829121 ttcatcttat cattatatcg tttatttatg gtacattttt gaatacattg gagccttggc 2829181 aaatcaaaac agcaaaaaag gagcaaacaa gcgctccctt ttgatgtttt ttcatatgaa 2829241 aatattatga gttctcatct accatgtaca aaataaactc ccaaaacccc ggtacatcct 2829301 gacataaaag catatcagcc ttttcaaaca ttttgatctt cagctcttgc tctaaatctt 2829361 ctctttcttg ataggacgta ttgctgagtt tttttctgat catcggtgaa aagcatgcaa 2829421 tcaggtgctc aatgtcataa gtctcgtctt tttgtttctt tttttgttca aactggccgt 2829481 ccacagctta cttttccccc tttttttgcg ccgctaactg ctttctgata ttctccagcc 2829541 cctttttatg aatgttggag atgttttgtc gggactcccc taatgaatct gcaatctcct 2829601 gcatcgtggc accgtgaaga tagactttcg tcagcacact tttttgtttg tcagtcagct 2829661 tctggatcgc ttggtagagc tggtaatcct gtacatgctg gctcaaatca tcctgcctgt 2829721 ctaaaaattc ttcaaatgca tcgctacctg tttcggaaga aagccgatct cccgcctccg 2829781 gatgatcaac cgtcagtgga taccgttttt ggtttttgcg aacccgctta tcaaaatcaa 2829841 tagaaaagat gcgaatcatt gaattcatat acttgacgat gcggatttct ttataaaatt 2829901 gcttaaatag ctcgtccaat gatcttgcat ctttttcgtt agggctttcc attacgtttt 2829961 tgaacaaacg gtaatgctga ggattgctca aaaaatgctt cacgatggga tgcttcatta 2830021 tctccttaca ttttgaccgt aaaagacttt gatagtccat caaaccgcct ccctactaaa 2830081 ttaaatgaag gaaagcaaaa aaaagtaaac tactactttc cgcctagtgt cttccaaaat 2830141 actttgcagc agtttacgtt ttatcggttt tcctcactta catacatgac tgcagaaaaa 2830201 gaagggaggt attttcctat ggatcaggtt tttatagagg aagtcgtaaa acagatcggc 2830261 aatttggggt ttcccgcgct gattgcaatg tatctgctga cccgattcga aaagaagttt 2830321 gatcaactaa tagaactaat gacagaactg aaagatcatg caaaaaaata atttttcaat 2830381 cgaagttgac ttttcactgg tttttttcac ttaacaaaac agaagggaaa acgaaaggcc 2830441 tttcaccttc tctttctgct atcacattta aatgtaagga ggaaacattt catgaaaaaa 2830501 caaaatgaca ttccgcagcc aattagagga gacaaaggag caacggtaaa aatcccgcgc 2830561 aatattgaaa gagaccggca aaaccctgat atgctcgttc cgcctgaaac cgatcatggc 2830621 accgtcagca atatgaagtt ttcattctct gatactcata accgattaga aaaaggcgga 2830681 tatgcccggg aagtgacagt acgtgaattg ccgatttcag aaaaccttgc atccgtaaat 2830741 atgcggctga agccaggcgc gattcgcgag cttcactggc ataaagaagc tgaatgggct 2830801 tatatgattt acggaagtgc aagagtcaca attgtagatg aaaaagggcg cagctttatt 2830861 gacgatgtag gtgaaggaga cctttggtac ttcccgtcag gcctgccgca ctccatccaa 2830921 gcgctggagg agggagctga gttcctgctc gtgtttgacg atggatcatt ctctgaaaac 2830981 agcacgttcc agctgacaga ttggctggcc cacactccaa aagaagtcat tgctgcgaac 2831041 ttcggcgtga caaaagaaga gatttccaat ttgcctggca aagaaaaata tatatttgaa 2831101 aaccaacttc ctggcagttt aaaagatgat attgtggaag ggccgaatgg cgaagtgcct 2831161 tatccattta cttaccgcct tcttgaacaa gagccgatcg aatctgaggg aggaaaagta 2831221 tacattgcag attcgacaaa cttcaaagtg tctaaaacca tcgcatcagc gctcgtaaca 2831281 gtagaacccg gcgccatgag agaactgcac tggcacccga atacccacga atggcaatac 2831341 tacatctccg gtaaagctag aatgaccgtt tttgcatctg acggccatgc cagaacgttt 2831401 aattaccaag ccggtgatgt cggatatgta ccatttgcaa tgggtcatta cgttgaaaac 2831461 atcggggatg aaccgcttgt ctttttagaa atcttcaaag acgaccatta tgctgatgta 2831521 tctttaaacc aatggcttgc catgcttcct gaaacatttg ttcaagcgca ccttgacttg 2831581 ggcaaagact ttactgatgt gctttcaaaa gaaaagcacc cagtagtgaa aaagaaatgc 2831641 agtaaataaa agacttgcgg cttgcagaga gcactcgttc tctgcaagcc ttcataagga 2831701 gctgaaccag tgaaacatca aaacccttca aaacgcttat tgcggctctc cataaagtac 2831761 ttgctggccg cagcagcagt ggtgttgacc tattttgctg tcatctatat attgttttct 2831821 ttagcgggaa cgagctaccg ctcagcagct catgtcctgc tttttgccgt ggtattcctt 2831881 gttctcggat tatgctttga accatttgaa cggctgatga tacatagctt tacatttttc 2831941 aagacaggaa aacgtctatt cattctcctt gctggcatcg tacagctgct gtttttgtgg 2832001 atgactgctc atacaacaga ccaattgatc agcgacatct ggctgtccac cacagaagaa 2832061 atgattgtcg cagccgtttt tttgatttta gacaaatgca actcggctct tcccagctaa 2832121 aaaaagaacg cattccaatt ggatgcgttc tttttattca tagcgaagcg cgtctacagg 2832181 ctgaagcttc gaagccttga tagacggaag caagccgaag ataatgccga ctgccattga 2832241 aaagatgagt gctccgacaa cagctggaat ggagacgata aaaggcatcg gaaaaatgac 2832301 cgtcagcagc ttggcgatgc cgaagcccgc cagcacaccg agtattccgc caatgcttgt 2832361 cagcacgaca gcctcggtta aaaattgaaa taaaatcaca cgccgcttag caccgagcgc 2832421 tttcttaatt ccgatttccc tcgtgcgctc cgttacggaa acgagcataa tgttcatgac 2832481 gccgataccg cccaccaaaa gtgaaatact ggcgataccg ccaagcagca atgcaaatga 2832541 ctgattaaag gactccactt cctgcgcgat ctcctgaaga tccattacac tgtactctgc 2832601 tttttccagc tcagcttctg acagtccctg atttaaaaga tctgcagcca ttacacccgc 2832661 ttcttggata tgctcagaag aatcagcctg cacggcaatc tgcgttggcg cgtcaaatcc 2832721 ttcaataagc ggccacactt ttttcggcac gtacaaaacc gggttcgcat agtcgccttc 2832781 aaacatgctt tcctgttgat ttttttcttt aaaaacaccc acgaccttaa acggcacacc 2832841 attcatctca atgcttttat gcagagcttc tccgtctgga aacagttcat ctctgacagc 2832901 ttcattgatc atcactactt ggtgtgtgct gtttaaatcg ttttccgtca gctttctccc 2832961 ttcggttatt cggattggaa acatgtcgaa gtaatcatcg tccactccat acacttgggg 2833021 atacgaaacg ttagttaaat gaaaaacgct cgcgccttct gacaagtaat ataaggataa 2833081 tcctttgacc atcggatctg atttgatcgc ctttactgtt tcttccgcta caggcggcgc 2833141 ggacgcatac gacacctgag ggccgccgct ctcctcttct ccgccagacg gctggtagac 2833201 aacattgatg gcgttgtttc ccatgccgat catactttgc tttaactgct cactttggcc 2833261 cttcagcatt gaaacaatcg cgatgattgc cgctatgccg ataatgacgc caagcattgt 2833321 cagaatcgat cttaatttat gagagaaaat ggattgaaag gagattcgaa tatgttcaag 2833381 catggctgat atcccctctc tcatctaata ccaactctcc gtctctgata aaaacggttc 2833441 tgtcagcttt tttggcgacg tccgggtcgt gggttatcat aataatggtc ttgccttccc 2833501 gatgcagttc agaaaacagt gccaaaattt gttcacttga tttggtatca agcgccccgg 2833561 tcggttcatc agctaaaata aacctcggct gattgacaag ggccctcgct atcgccaccc 2833621 gctgcttttg gccgccggac agcttaggcg gtttgtagga gaccctgtct tttaatccga 2833681 ctttttccag cgcttcatat gcccgttgcc ttctctcttt tttcttcact ttattgtaga 2833741 tcatcggcag ctcgacattt tgcagcgcgg tgagacgcgg cagcaaatga aaagtttgaa 2833801 acacaaaccc gattgattca ttgcgaattt cggctaaagc cccgtctttc cctttcaata 2833861 tatcgatctg gtcaagcgta taggttcctg aggttggcct gtccaaacag ccgataatat 2833921 tcattaacgt tgactttcca gaaccggaag gccccataat agctaaaaac tcccccgcct 2833981 gaacggtcag attgatatgt ttcaagattg gaacttcttc ttttcccagc ttgtacgact 2834041 tcgaaatatt attcagtgtc agcattgact gtaacctgct ttccttcctt gaccgcggga 2834101 tcaggataga tcacataatc ttccggcgtc aggccgctct taatttccac catgtcattt 2834161 tcatcagtct ctccgatttc aacaggctgc ttaaccgctt tgtgattctc atcagctttc 2834221 catacgtacg gttcgccgtc atcctgaatg accatgtcgg acggcagctt gatcgtgtcc 2834281 gcatcagcat tatcactcat cacttcgatg ttgacatgat agccgacttc aagaccttta 2834341 tggctgtcta ataaaatggt gaaaggatag ttagaggact ggggattcat ttcttcatca 2834401 gcaaagcttt ctgattcttc accctcgcct gctcccgctg gaagcttgcc gatcgaggtg 2834461 acctttcctt tccactcgcc ctcaccgcct gttttcagcg tgaccctgac tttgctgcct 2834521 tttttgatcg tgtccattaa cagctcattg atttggcttt tgaccagata tttgcctgtc 2834581 gaaacaatct ggatatacgg gcctgctgcc tggtcgcctg ttgcaccgtc agcgatatcc 2834641 tgattgacgc tttgaacgat tccgtcatgc ttgcttgtaa tgacattgga acctttgttt 2834701 ttcgtcaggc cagccagttc tttttgatgc tgcttcagtt caagctggct tgttttcaaa 2834761 tcgaaattgg tttgatcaag ttcatcttga agctggtttt tctcttcttt tcctgcaact 2834821 ttcagctttt tttccgtttc cgttattgat ttttgcaaac ggttgatttg cagatttgtc 2834881 atttcaattt gcaaattggc ttgctccact tcatcagaat gatcctcgcc ctcatactca 2834941 aaaagcttat cgcccttttt aacctgatcg ccttctttga cgtatgtttt tttaatgctg 2835001 cctttttctg aatctatgta tactttctgc tgtttctcag gttcaacctt tccagaaaac 2835061 gtttggcctg attctgaatc tcctcccatg tataccgcga ccgattcagc atagggctcc 2835121 gatgatacgg caacttggtt catgtgagta aaaaagtaaa aaccgccagc gccgatccca 2835181 gccaatacaa gcacaccggc acatatcgca ccgccaataa gccatttttt cttcttggac 2835241 acaacgatct cctctttctg taaactatgt aatattttcg aaacattcta accaatatta 2835301 tctattaatt caaaaagact tgcaatcctt ttattgaaat gacggaatca aatagaaaaa 2835361 ttgtattttc aaagccgaat aaaaaaaatc ccggcttcaa accgggattt tttcatacag 2835421 taactagctc tttttcattt ttaatcaagt catatgtcaa gcatacaggt ttatttgtac 2835481 ggggatcagt cacgatttcg gcatcaatct gaaatacctg cttcaaaatg tctggtgtca 2835541 tgacctccag agcagttcct tccttgatga ccgtgccttt tttgagcgcg atcatataat 2835601 gagaaaaacg agctgcatgg ttaagatcat gaatgaccat taaaatcgtc cgcccttgct 2835661 ctttgttgag tctgtcaagc agctgcagaa tttcaagctg atgtgcaaga tcaagatacg 2835721 ttgtaggttc atccagcaga agcagttccg tcccttgcgc aagcgccatg gcaatccaca 2835781 cacgttgacg ctgtccgcct gacaatgcct caatcggccg ttcagcatat tcagccatgc 2835841 ctgtttcttc aagcgcccat ttgataatcc ggcggtcttc gtcatttaat ctgccgaatc 2835901 ctgattgatg cggaaacctg ccgtacgaca ccaattcgtg cactgttagg ccgctcggcg 2835961 cttcaggtgt ctgtggaaga atcgccatat cttttgcaat gtcctttgta gacattttat 2836021 gaatcgcttt gccgtttaaa tagacggcac ctgcatgtga acgcataatt ctggacattg 2836081 tttttaaaat cgttgatttc ccgcagccgt tcgggccaat taaggtggta attttccctt 2836141 taggaatcga tatatttaaa tcctctacaa tcaccctgtc gccataaccg attccaagct 2836201 gttccgttga taatgaattc atattcggcc ccctcctcta attcgctttc atcaataaat 2836261 aaataaagta aggcgcacct agcacggaaa tgacaagtcc gaccggaatt tctgatggtg 2836321 ccaatacatt tctcgccagc gtatcagcaa gcaaaaacag gaatgagccg atgaaggcgg 2836381 agaccggtat cagcgtctgg tgacgtggac cggtcagcct tctagccaca tgcggcgcga 2836441 tcaatccgag aaacgcaatg ccccccgcag ctgccacgca tgaagcggca agagtgaccg 2836501 ctgccagaag aagaatccgt ctttcctttt caacagcggt gcccagcccg gtcgccaatt 2836561 ggtctccgag ctgcataatg ttcaaatagc gtgccttata taaagtaaac agaagcaaga 2836621 tcacaatcca agggagaatc gcccagatca tattccagtt cgccccccat attgagccgg 2836681 atatccaaac cgcggcttgc ataaaatcat gagggtccat cttgagctga aaaatcagca 2836741 acagggcgtt gaatccggca ttcaccccta tgccgactaa aatcagccga atcggtgtca 2836801 cgcctttttt ccatgccaga atataaatga gaaacgcagc gaggattgct cctgccaaag 2836861 cactgaacgg cagcataaat gttccgaaaa agctaagatc tgaagctgac ccttgaaaaa 2836921 agtatataaa aagcactaca gcaagtgaac cgccggcgtt aattccgaga ataccaggct 2836981 cggcaagttc attttgagac acgctttgca aaatggctcc agctacggag atccctgctc 2837041 caacaagcaa agaaaggatg atccggggca gcctgaactc aaataagaca agttcatcac 2837101 gcgccgttcc ttggccgaaa aagacctgaa gcgttttaag cggtgcaatt ttgataacgc 2837161 ccaaattgag actgataaaa aagaccacca cgataagcaa aaaggtcaca gccattacaa 2837221 tgagcggttt gtttgttttt gttttcatta cagccctctc ctttcacgac gtgccaaata 2837281 aaagaaaaag ggaacgccga taagagaagt cagcgcgccg acaggcgttt caaagggcgc 2837341 atttacgagt ctggccgcta tgtcagcaaa aacaagcaaa acagcaccga gcaccgccga 2837401 gcaaggaatg atccaccgat aatccacacc gaccaaaaaa cgggtaatat gcggaatgat 2837461 cagcccgata aatgcaatgg tgccggcaat ggaaaccgca gctccggtca gaattactac 2837521 aataagcatg ccaaccagtt tcaccgctga tgtatattgt ccaagccctt ttgccagatc 2837581 gtcaccgaga cttaacactg taacagaccg ggcgatgaaa aacgcgagcg ttaaaccgac 2837641 agcccctgca ataagcaaaa gctggacccc cgaccatttc acacccgcta ccccgcctgc 2837701 gtaccaaaag ctgatatcct gagcgacatc aaagcggatt gcaatggcag ttgaaatgcc 2837761 ggtaaagaaa taagtaactg ccgtacccgc cagagcaagc tttacaggcg taagtccgcc 2837821 ccttgaaaac atgcctatgc ccattaccgt cgatgccccc agccccgctc ccgcaaagga 2837881 ccatagcaca agccccattg cagaaagtcc gggaaaaaag gcaaacgcaa tcgaaaccgc 2837941 aaacgcagag cctgatgtca cacccataat cgaaggctct gccaaagggt ttctcgtcat 2838001 cccctgcatg attgctcccg acactgccaa caatgcgcct acaagcgcgg cagccgccgt 2838061 tctcggaagc cgaagatcat gtataatttg gtgagatgtc tttgtcggct gataatgaaa 2838121 aatggcctcc catacagtgc gcaaatgaat atccgctgca cctagggata tggataaaaa 2838181 tgcgccaagg caaagcaggc atagacctgc gataaggacg atgaccgcgc catatgtcct 2838241 tgacgtccat tggatttctt ctgatgcagt ccgtatattt ttatgttgac tcaactgccg 2838301 tacttccttt ctgttactga taatgattat caattgctgt ttcagtatat cacttttttc 2838361 agctgattta atagagtgtt ttgaacaaaa atgaaaatgc atttgcaaaa atatcgtgtc 2838421 aaccggcact tgcagtggta taatcacaga tgataatgat tctctttttc atctatcttt 2838481 tagaaagaag gtatgagata tgacccatat atacaagaaa ctcggagccg cgttttttgc 2838541 cctgttattg attgcagcgc tggcagcctg cgggaataac tcagaaagca aaggttctgc 2838601 ctctgattca aaaggcgcag aaacctttac atacaaggct gaaaacggaa atgtaaaaat 2838661 cccgaagcat cctaaacggg tggttgtcat ggcagacggc tattacggct acttcaaaac 2838721 actcggcatc aacgttgtag gtgcgcctga gaatgtattt aaaaaccctt actacaaagg 2838781 aaaaaccaac ggcgtcgaaa acatcggaga cggcacttcg gttgaaaagg tcattgattt 2838841 gaaccctgac ctgattatcg tctggacaac acagggcgct gatattaaaa agcttgaaaa 2838901 aattgcgccg actgtcgcag taaaatacga taagctcgac aacatcgaac agctgaaaga 2838961 atttgcaaaa atgacgggaa ctgaagataa agctgaaaaa tggctggcca agtgggataa 2839021 aaaagttgcg gccgctaaaa caaaaatcaa aaaagcggtc ggtgacaaaa ccatttccat 2839081 tatgcaaacg aacggaaaag acatttacgt atttggtaaa gactttggaa gaggcggaag 2839141 catcatttac aaagacctcg gcctgcaggc tacaaagctg acaaaagaaa aagccattga 2839201 ccaggggcca ggttatacaa gtatttcatt agagaagctc cctgacttcg ccggagatta 2839261 cattttcgcg ggcccatggc aatcaggcgg tgatgatggc ggcgtttttg aaagctccat 2839321 ttggaagaac ctgaatgccg ttaaaaatgg ccatgtatac aagatggatc cgatcggatt 2839381 ctatttcaca gacccgattt cattagaagg acaactggag tttattacgg aaagcttgac 2839441 taaataaaca aaagagccgc ctgcccgcgg ctcttttgct tatttataag gaacggctca 2839501 atttgaatca tatcggatat tttctttgag ccattcatat taagctgcat cctcatcacg 2839561 atcagttttt ttatgctgga gagactgaaa aacgtttttt gcatatttaa cgaacggatt 2839621 cctaacagga gaaattgtga ttttataaaa aagacacctg agcaaatcag gtgtcttttc 2839681 attatgcttg tttttctttc tggaacttgt tactcacaaa tggataaacg attaagccga 2839741 caaagaataa accgatgccg agtataaatg tcgttaaatc tgctgtgcct gttacgataa 2839801 caaacacgga gtatgcacac gccagtatcg cgatcaatcc gtctcttaca cgggagcctt 2839861 tcagctggtc atacgtttca cctttgatga ctaccttcaa gctgtagatt gcagatacca 2839921 gatacggaat taaatatgcg agtgtagccg ctgtcgttaa aaatgtaaat gcgtcactta 2839981 ttgtccggga aataaccgag aaaatgaaga cctgtgacat gacgtttgta ataatgagtg 2840041 caatgaccgg acttcccttt ttattcgttt ttgcaaaaaa tgccgggaaa tctcctgctt 2840101 tagcggcttg gtatggcacc tcagagccaa gcaaaatcca gccgagcatc gttccgaata 2840161 aacaaaggat agccaaaagc gccataatca cgcttcccgc gtttccaaca atcgcataga 2840221 gtacatcaac aaatggtttt tcagagccga caagcttatc atgcggcaga acacccatcg 2840281 taattaaagt cacaataata tatatgctca aggcaatcag caagccggta attgtcgcac 2840341 gtttcacatc acgctgagag cgcgcacggc cggacaggat caccgcggat tcaattccga 2840401 caaacgccca cagtgtagaa atcgcagcgt tatgaacctg gccaccaatt ccaatgcttg 2840461 tgccgttttc tccttgaacc gggaaataaa aatgaccgaa taatgacgtt tgaaacacaa 2840521 acaaaccggc aacgataaag aagacaaaac ctaatacttt agaaagcgtt gtgacaaagt 2840581 ttaatttact tgcgccgtta atgctggcaa caagaatcgc gtgcgttccc cataacaaga 2840641 tcgtacatac ggcaaacgtc agtaattggc cgagtgtcac ctcttgcccg ccgatcgaaa 2840701 acatctcacg tttatcaacc aagatcggga agaacgaagt caagtaaccg gcgagacttg 2840761 tgatgatcgc cacgttactg atccagctcg ccacccagta gccccacacc attgtgaaac 2840821 cggcagcgtt gccttttttc gggtcagaaa acagcgctct tgcataactt tgcggtcccg 2840881 ctgtcagttc aggcttgcga atggacaagt gtccgaacac aagtgcaatc atcagcacgc 2840941 cggcacctgt caaaagccag gcggacgtag ctccaaacgg actcgcaatt gaagcaagcg 2841001 agctcggcaa ggagaaaatt cctgatccaa ccatatttcc aacgacaaac gccgttaata 2841061 accaaaaacc ccattttttt gtctgttcca ttccagtacc tccatgattc tttgtacgga 2841121 ccagaccccg agatcatata aacgcaaaaa aagcctgaac aaaagtccat gcttaaagaa 2841181 acacacaccc ttgatctccg gatagccctc cgcgaaaaag cacgcggcag tcctgcactt 2841241 attcagatac agtcccagca tagagaagga tcggctttct ccacacttcg gcgctgatgc 2841301 cttttacaca tgtttaacag cccctgtcag cctagcatgt gtgactcatc atccgcgcaa 2841361 cctctacctc actgagaaag agtgaggatt taattattca gttactccca gaaggttatc 2841421 aaagaaagga tgatctgtca aagggaacag atggaaaata cggatagagc caagccctat 2841481 ccgcatgtgg ttatcgatta tttttctttt tttgcacagc ttcttgaagc ggatcatctt 2841541 ttagagctga accagcatct tcaagagctc cttggattac gtttttttct ttttcggaac 2841601 gttttccttt atctttatta aagaaaccca ttcgtatcac ctcttttaaa aaataggtac 2841661 atgtttaaga tgcctttttc ctgaaaaatt atgcgggata ttttttatcg tccaaagtcc 2841721 tgttgatcaa acatacattc tcttgatata tttgtaattc agagattttt tgcaaaagat 2841781 aaaaggagaa gcggcaaatg acaggaaaaa cacacatcat gggaggcatc gcttcttgta 2841841 cggcagcggc ttattattat ggatttgatc cagtgcttat ggctgcgtca ggcgcggttg 2841901 gagcattaat acccgatatc tgccacacac aaagcaaaat cgggagaaaa tttcctattt 2841961 tatcgaaagt ggtcagctcc gtttttggcc atcgcacctt tacacacagc ctgctgttta 2842021 tgctcatcat gttttttatc acttctacat acattccaga taaaaacata tcagccggcc 2842081 tgatgatcgg aatggcgagc cacttgattc ttgacgcttg gacggtgaac ggaatcaaat 2842141 tattattccc ttccacgatc cgcgttcggc ttccattata tatgaagaca ggcagttttt 2842201 ctgagcagct cgtgctagcc ggcctgaccc ttgcttcatg ttactacttt tatatgctgt 2842261 ttcatggccg catgttttaa acatgagtgc tgagacttgt ctgaaccggc tgtttttagt 2842321 aggttttact taagaagcat ttcatgcaga tgatcaagaa aacgtgagga gtcatattga 2842381 tgaaaggaac cttttttcac aatcagcggt ttttatgttt ttcgatctta tttatgtgga 2842441 tcaaaacgta tgtgatatat aaactcggct ttgatttgca aatcgatact ctgttggagg 2842501 agctaatgct gctggtcaac ccgctcagct ttattcttcc tttattcggg atcggcctgt 2842561 ttctaaaaga aaacaagcag cgggcctttt tgctgattgc caatttggtt ctgactgtta 2842621 tcttgatctc taatacgatt ttttacggct tttatatcga ttttattacc atcccggttt 2842681 tatttcaggc cagcaacatg agcgatatgg gcagcagtgt aaaagaactg ttccatcctc 2842741 tgtttatcgc cctgtttgtg gatttggttt ttctgctgtt gttcgccaga aaaaccaaac 2842801 acccacagac aaaagccgct ccccacacga tcaaacggta ctatgcagct tcctgcggaa 2842861 tgcttttatg cacactggca cttgcagaag tacagcagcc gaagcttttg gcacattctt 2842921 ttgaccggga aatgctagtc aaaagcatcg gcctgtttca gttccatatt tacgatacaa 2842981 tttctcagac tgttaatatc agcgcgaaag cttttgccga tgaagacagt ataactgcca 2843041 ttaaaaacta cacagaggct gattacagca agcctgatca aagcaaattc ggtcttgcaa 2843101 aggggcgcaa tgtcatcttt gtaacacttg agtcgaccca aagctttgtt ctgaatgaaa 2843161 aagtaaatgg aaaagaaatt accccattta tgaatgatct cataaaaaaa agctattcct 2843221 ttgatcattt ctatcagcaa acagaacaag gcaaaacatc agattcagaa tttatcgtcg 2843281 ctaactcact gtatccctcc cttagcggcg ccgtcttttt cacgaaaagc gaccatcaat 2843341 ttcatacgat gtataaatcg ctgaagcagc acgattatta ttcagccgtc tttcacgcta 2843401 accataaaac attttggaac agagatgtca tgtacgatac atttggcatt gaccgctttt 2843461 ttgatgttga tgattttcat gtcactcccg ggacatcgac aagctggggc ttaaaagaca 2843521 aagaattttt agagcagtcc gccaaaaagc tgaaaagcct accgcagccg ttctacagca 2843581 gttttatcac gttaacgaat cattttccgt ttgagattga tgaaaaggat cagctgatag 2843641 atgaattcga ttcaagcagt gatctgttaa accgctatgt gaccacggtt cgctatgagg 2843701 atgaagcatt gaagcatttt atcaaaaaac tgaaggacga aggcttatac gaaaattcga 2843761 tgatcgtatt tatgggagat cattacggca tttctgaagc ccataacgag gcaatggctg 2843821 agtttttagg gaaagacgaa atcacaccgt atgacaacgt tcagctccag cgggtgccgt 2843881 ttatcataca tatcccggga atcaccgatc aacagccgga aaccatccct gatgccgggg 2843941 gacaggtcga cgtcaggccg acgctgatgc atttgctcgg cgttgagaca aaaggcgata 2844001 tccaattcgg caatgatttg ctgtcgggcg accgcacccc attcgccgtt ctgcgaaacg 2844061 gcagctttat tacgaacgat tatgtataca caaagaacac gtgctatagc caaaaaacag 2844121 gtgaagtgct ggaagatcag gatgcgtgcc tcccttacaa ggagaaagca aacgaagaac 2844181 tgtctctctc tgataaaatt ttaaatggtg acctgctcag gttttccgaa tgaaaaaatc 2844241 cctctatcaa gagggatttt ttacgtttcc aatatcacct tgccagtcag cttcgtttca 2844301 tagccgttta aatgagacag attcgccttg tagtcctcag aattcaaaat ctccttcacg 2844361 gctttgagca actgctcatt ttttttcaaa acaacgatat catattgttc gtcgatgagc 2844421 gggataaaat caacactgcc catatgtgcc gcgtgctgtg ccccgattcc cgcgtcagcc 2844481 tgtccgcttg aaacttgtga agcggcagcg taatgatcag tcacgatatc gccatatccc 2844541 actacatcag ccggattcac accaagcaag ccaagctgtt catcaaggag cacccttgcg 2844601 ccagaaccct tttccctgtt gatgatccgg atatcggctc ttttcaagtc tttccagcct 2844661 tgaatgtttt tcggattccc tttttgcaca tacagtcctg ctttgcggag aacgacattg 2844721 atgagacaaa acggttcacc tgtcaaaatc cgttttacat aaggcgcgtt atactggccc 2844781 gtttctgcat cgtacaaatg gaggctgaca atgtcacact tgccttgata catatcaatc 2844841 aggctgttta agcttccttt gtatttacgg agcggcgtct cctgaatggc attctccaaa 2844901 tgcttgctga ggatatccat cgaaatgtcc tgtccgctga tcatgacatt tggtctgccg 2844961 tccggctcag cctcctgcac ctgtttcggc gcttcttttg cagcgatggg ctgagacatt 2845021 ctcatattcg ttttatattg ctttaaatct tcttcatcca cacgcatctg ccttccgaca 2845081 cggtaagcag gcagcacgcc ttttttaatc aagtcataaa cggtcagctt tgataccttc 2845141 agcagacctg caacttcttc tatcgtatag gaagaggttt cattcatcat catcactctc 2845201 ctattttatt ataccttttc gccgaatgta aaaaaaccca cataaaccaa acataatcag 2845261 ttataattag ttatatctaa tgataagggg tgcaatcatg tttaagaagt attctatttt 2845321 catcgcagcc ttaactgctt ttctgcttgt agcaggctgt tcttcaaacc agtcttcaac 2845381 ggacagcgag aaaaaagtaa cgttaaccat ctcagctgcc gccagcgcgc aggatgcact 2845441 tgaggaaatc caaaaaaatt atgaaaaaga tcatcaacat ataaccatcc aagataacta 2845501 tggctcatcc ggcgccttgc aaaaacagat ttctcaagga gcaggagcag atctgttctt 2845561 ctcagctgct gaggataaat ttaaaaagct ggtggatgat ggagatatcg caaaaaaaga 2845621 cagcactgaa ttagtcggta atgaaattgt gctggtcgta ccgaaaaacg gagattcacc 2845681 tgtgacaagc ttcagcaatc tggctgaatc agaaaaaatc gctcttggca ctccggaatc 2845741 cgtaccggca ggagcttatg ggaaagaatc actgacaaag ctgtctttat gggacaaagt 2845801 gaaggataaa attgtgtatg gaaaagacgt tcgccaagtt ctttcttatg ttgaaaccgg 2845861 caatgtagac gcaggtgttg tttataaaac agatgcccta gtctcgaaaa aggtcaacat 2845921 tgttgacgag gcaaaagcag atacacacag cccaattgtc tatccgttag gaatcgtaaa 2845981 agatacaaaa caccgtaagg aagcgaagga attttacgaa tacctgcaat ctgatgaagc 2846041 aatgaaagta tttgagaaat atggctttac tgccgagtag cataagcgct tcagaatttt 2846101 tcacacccgt tgtgctttcc tttcaggtgg cggcagttgc cggaattgtt gtcattattc 2846161 tcggaacact tgctggagca tggatgtcac gggcatcatt tttcggaaaa acggcactcg 2846221 aaacatgttt tatgcttccg ctcgttcttc cgcctactgt tgtcggtttt attctgatcg 2846281 tcattttcgg aaagcacagc ttcatcggac aagccatcga gtggattttc cagcagcctg 2846341 tcattttcac ctggtgggcc gctgtgatcg cctcggctgt tgtagccttt ccgcttatgt 2846401 atcaatcagc caaaaccgga tttgctgaca ttgatcccga tatacaaggt gcggcaatgg 2846461 tagacggcgc tagcagatgg aaagtgttta tccatatctc cgtcccgctt gcctatcctt 2846521 cgttactgac cggaagcatc cttagccttg cgcgggcgct cggagaattt ggcgcaacac 2846581 tcatgtttgc aggaaacatc cccggtgtta cgcaaacact gccgacggcg atatatgtcg 2846641 cattggattc cggcaacaat acccttgctt gggcgtgggt cgtctgtatt gttgtcattt 2846701 cctttttgat gctgtttttc attcaacaga aaaaaacgca ctaaaaaaac tccccataac 2846761 ggggagtttt ttgattaaaa cagaagctca tcaggatttg gaccgacacg ctcatcttta 2846821 tttaatgcgt caattttgtc catgtcttct tgagacaatt cgaaatcaaa aatatcagcg 2846881 ttttcgatga tacggtgttc tttaatggat tttggaatgg ttacaactcc atgctgcaga 2846941 tcccagcgca aaatcacttg agccacagat ttattgtgtt tttcagcaat ctgtgtcagt 2847001 acttcgttat ccaaaagctg tccctgcatg agcggagacc acgcttccag ctgaatgcct 2847061 tgccctttgc agtaatctct taattctttt tgcgtcaagc gagggtgaaa ttcaacttgg 2847121 ttcaccatcg gtttgatttc agcatctttc aacagctctt ctaaatgatg aacttggaaa 2847181 ttgctgacgc cgatcgcgcg aattttgccg tctttgtaca gcttttcaag cgcgcgccat 2847241 gtatctttat atttatcttt gccaggccaa tggatcaaat ataaatctaa gtaatcaagc 2847301 tgcagtcttt ctaggctttt ttcaaaggca gcaagcgttg tttcatagcc ttgatcttca 2847361 ttccacactt ttgatgtgat gaagagctct tctcttgcca caccggattc tttaatcccg 2847421 atgccaacgc cttcttcatt tttgtagatc gctgctgtat caatactgcg atagccattt 2847481 ttaattgccg ctttcactga ttcagtcgct tcattaccat tttctacttt aaaaacgccc 2847541 agaccgaacc aaggcatttc aactccgtta tgtaacttta cagtatcttt taaacttgtt 2847601 ggcacttgaa cctccaccct ttcactgaaa tgtaagcgtc tatattatct cacattcctc 2847661 tcagccgata ccaataatac gcttaagacc ctctttttgc ttcttttttc acagcacagg 2847721 caaatccaaa cactattttt ttcctatttt aacaatattg agattacaaa tacattgagc 2847781 agggtatgcg tgtagtgtaa ccaaatgaaa acaaaggagg aaacaacttg aaacgtattc 2847841 gtatcccaat gacacttgct cttggtgccg ctttgacaat tgcccctttg tcctttgctt 2847901 ccgctgaaga aaatcctgct ccgaagatgt cgcagacaac tactgctgga acaactgccg 2847961 ctgatgtagg tttaaacgtc aacctggatg tacttggaat tgccaaccag atcgctgatg 2848021 ccatcaaatc cgcacagaat agggatggct ttgtgaaaaa cctcatggag tcttccttct 2848081 acgcgtccgg ccaaaaatat aacgtcatgg tctttaattt aagccaggaa tatgaagatc 2848141 atttgaacgg tgtgcaattt tacggctcag ccgtttacga cggcattacg tatggcattt 2848201 gggtatttga agatggaacc tttacaaaca aaggcgatgg cggctggatc aactgggcct 2848261 tcagaggctg gttcgaccgg gatggcagca ctgtcgcatt tcatcgccct taatataaaa 2848321 aaagctggcg ctctaacgcc agcttttttt ctgcatttat tcgccgcctt caagcatggc 2848381 ggcttcgaca tcattaatgt attggcgaag ctcatgggag atgtcccggg aaatttccct 2848441 ctcttcgaag agcgtttgaa tttcatttct gatcgcctgc acagccttca gcttcacttc 2848501 cagcttctga ttttcaaaat gggcacttga ttttaactca tgatggctgt gctccagcct 2848561 gaaaattaac tgcttataga atgtaatgac agataaaaac acttctttat gctcatccgt 2848621 cttatgtttt tccagatatt ctatcgctgc ttttgccgtt ttcactcttg ttgcccgtat 2848681 caatcccgct tcatttaaaa tcgacatctc cggcttttta tgttcaccga agaaaatcca 2848741 atacatcagc ctcttgagcc ttgtttttga taacccgact ttaaacgggt tggcatacaa 2848801 aatttccaac tcgttaaatc gttcttgcag cacatttgct gtttcttccg ggatgtctcc 2848861 ccgctccagc attttcatca gcgcctcttg ctcagcctta accccctgcg cacggacttt 2848921 tcgctcgtgc ttcttaatgc gattagatga tgtatactgc tgaaaacgaa gatttttcat 2848981 tttctcattg tattcagcta tcaccgcaag agaggccgtt ttgtttgtct cattcatgtc 2849041 ctctttaatc gtttgaaggg ctgttttgat caacttgcgt ctcgccgtca gcagcttctt 2849101 atttcgttcc tcgtcctctt cttctttttc agtcagaatt ggcagcacaa cggtggcaat 2849161 gacaagcgtg cataaaatga cgccggctgc taaaaagaga atcagatttc tttccggaaa 2849221 cggcgtaccg tcctccagga aatacggaat ggaaaaagaa cctgcaagcg ttactgctcc 2849281 acgcacaccg gaaatcgaaa ttaacagcgt cgaacgaaga cccggtttat agatgttctg 2849341 atctttatta aagaaccatt tgccgttcca gaagaacagc acccacagga atctaaggag 2849401 cattaatgta aatgtgatga ctaggatata gccgatcacc ttcatgttgc tgatggcagt 2849461 gtcgttaaag ataacagaaa taacatcagg gatttgcgtg ccgagaataa cgaagaccag 2849521 gccgttcaaa ataaataaaa taatgttcca cgtacttgag gagacgattt gcagcttgat 2849581 catcgttgat tccagacgat cctgttcaac cgcatgggta ataccgccag ctacaacagc 2849641 taaaatgccc gaaacgccga tttcttcagc tgccaaataa atcacaaacg gcgtcagaat 2849701 ttgaatcagc atatgcatcg tgacatcctg catgccaagg cggcgcagaa ataggcgaaa 2849761 acgaataatc aaaaatgaaa tgacaacccc gcacagcaag cctccgagag aaataaagac 2849821 aaagctgaca gccgcttgtg ctaatgaaaa tgcaccagtc actgccgctg caatcgcaaa 2849881 cttaaaggcc accagacctg atgcatcatt catcagcccc tcaccttcca gcaggcgaag 2849941 aatccctttt ggcattttca ctcttcctga taatgcgctg acagcgacga catcagtcgg 2850001 tgaaagaatg gccgcaagtc caaaggccgc tgccagcgga atagcaggaa tcatccagtg 2850061 aatcgtgtag ccgcctacaa tcacagtcgc aaatacaagg ccgagtgcaa gcaataaaat 2850121 cggagccctt aaattccaaa gctctgcccg cggtgtcctc tttccatcat taaatagcag 2850181 aggcgcgata aaaagaacaa aaaacaattc ggtgtttaat tcaaaatgaa gtccctgtgg 2850241 aaatgaggcg gcaagaatcc caagagccac ttgaatcagc ggcaccggaa taaacggaat 2850301 aaaccggttc acgatattag aaatcgcaat aatcgttaat aatacgagca caactaaaaa 2850361 tatgtccaaa tgcatgacct ccttcgtctg ttgtgtgtcg gcatgatgag ccaaaaaatc 2850421 tgtttgtcta aaagcccttg agctagggtg gccttgcatc cgctatgtgg tttcgcagga 2850481 gttctctcca cacttgtctt cttttatagt acccttttta gggtattttt tctcatgata 2850541 tgctcacagt gaactttttt gcagaagagc aaattataga aaaaagagac aggaagctac 2850601 tccctgtctc tcgtctttct ttctcaatca tgaaaattcg taccgtcagt tgttgcttta 2850661 ataatgcccg cgcgaatgac aaagtcaccg aaatgctcgc cttcctcgcg ttctttcgca 2850721 tagcgggaaa gaaggatgcg cagctcgctt aaaatgtctg cttcaccgat gttttcacgg 2850781 tacattttgc ttaaacggct tccgtcaaac gcagcgccaa gatacatatt atatttgccc 2850841 ggcgcctttc cgataaatcc gatctcaccg agtgcatgac gtgcacagcc gttcgggcat 2850901 cctgtcatgc gaatggtgat ttcctgatca cgaaggccgt tttcgtcaat aatctcttca 2850961 atcttatcta acagggtcgg caaataacgt tctgcttcag ccattgccaa tccgcaggtc 2851021 ggaagagcga cgcacgccat cgagctgcgg cgaagcgctg aatagtgctt gccgtcagtt 2851081 agtccgtact gttcaattaa agcactgatt tcttcttttt tatcgcttga aacgttcgca 2851141 atcattaagt tctgattggc tgtcagccgg aactcacctg tatgaacttt ggcgatttcc 2851201 cgcaagccag tcatcagctt ataatcatcg taatccgtta tacggccgcc ttcgacaaac 2851261 agcgtgaaat gccatttatc ctcgatgcct tccacccagc catagcggtc gccgttatga 2851321 tcgaaatgat acggcttcgc ttcttccagg ctccagccga gacggttttc caattcttct 2851381 tttacgtttt ctaaaccgag gcggtcaact gtgtatttga accgcgcatt tttacggaca 2851441 gaacggttgc cgtaatcacg ctgaatcgta atcgtttttt cagcaacgtc atacatttgc 2851501 tcaggccggc agaaaccgat caccttggct aattgcggat atgtcgcagt atcgccatgc 2851561 gtcattccca taccgccgcc gattgccacg ttaaaaccga tcagcttgcc atcctcgaca 2851621 atcgcaatga atccgagatc ttgtgaaaag acgtcaatat cattagacgg cggaacggca 2851681 ataccgattt taaacttccg cggcagatag agcggtccgt acattggctc gacttcttcc 2851741 tccggcgtgc cggcaactct ttcctcatca agccaaattt catgatatgc tctcgtccgc 2851801 ggcagcagat catcacttaa ttttttagac cactcgtata cctctgagtg gatttcagat 2851861 tgataagggt ttgatgcaca catgacgtta cggtttacgt ctccgcaggc tgcgatcgta 2851921 tccaaaagtg ctgagtggat cgtctgaatg gttttcttca tgttccattt cagaattccg 2851981 tgcatttgga atgtttcacg tgtcgtcaat tttaatgtgc cgttcccgta tttctgggac 2852041 aggtcatcca tgacaagcca ttgttcaggc gtcgagacgc cccctggcat acgcacgcgc 2852101 agcatgaact gatatgcggg ctcaagcttc tgcttttggc gttcatttcg gaggtcgcgg 2852161 tcatcctgca aataactgcc gtggtgtttc atcaggcggt tatcatcatc cggaattccc 2852221 gcactgattc gatcgagcat cacttctttc agcgtgccgc gcaaataatc actttctttt 2852281 ttaatgcgtt caacatcact tggagagccg tccggtgctt ttagaatttt ggtcaccatg 2852341 ttgaaaaact cctttcaagt caaatcaata tacatcacgc tgatagcgtt tttgctgctg 2852401 catatcggca agataagcct ccgcctcttc gcggctcata ttgccttctt tttcgataat 2852461 ttcaagcaat gtgttatgga cgtcatgcgc catgtgcttt tcatctccgc aaatgtaaac 2852521 agccgctcct tcttgaagcc attcaaacaa ttctgcgcta tgttcaagca tgcggtgctg 2852581 cacatatact ttttcttccg tatcacgtga gaacgccaca tccatttttg tcagcacacc 2852641 gtctttgagc caattctgcc actctgtctg gtaaaggaaa tccgtgacaa agtgctgatc 2852701 gccaaagaac atccatgcct ttccttccgc tcccgtctcc tcacgctcct gcataaacga 2852761 acggaaaggt gcgacgcctg tcccagggcc caccatgata atcggtgttt cagggtcttt 2852821 cggaagctta aagttttgat tgtgctgtac ataaaccggc agtgtgtctc ccggctgcag 2852881 tcgttccgcg cacaaaatcg agcagacgcc ttttcgttca cggccgtgcg catcgtagcg 2852941 gactgcgccg attgttaagt gcacttcatc cggatttgcg gataaactgc ttgcaatcga 2853001 ataaaggcgg gcaggcattt ttcgcaaaat cgagacaaac tcctgcgcag atacactaaa 2853061 tgggccatag tcacggacga gatcaagcaa atcgcgccct tcaatatagg cttttacatt 2853121 ctcctcattt cccggggcta aaagctctct aagctcatcg ttccctgtca gctgggctgc 2853181 ctgttcaaga agcggttttg tgagaacggt aatctcatag tgagaaatca gcgcttcttt 2853241 cagcggtcgg acatcacctt gcttattaag cgtcacaatt tcttccgggt cccaattcat 2853301 ttccttaagg agcagctcga caagttccgg atcgttttcc ggatagacgc cgaggctgtc 2853361 accaggctcg taagtcaggc cagatccttc aagagacagc tccacatggc gtgtttcttt 2853421 atttgatcct ctgccgttta aatttaaatt ttctaacact tcagcccgaa acgggtttgt 2853481 tctggaatac gaagactcac cggtttgtga cgcagccgcc ggcgcaggcg cggcgcttcc 2853541 gcccccagct tcatttaatc ctttcaatac accctcaagc cattcggctg ccggttcatc 2853601 atagtcaaga tcgcaatcaa cgcgcggaga aatccgtttt ccgccgagtt cttctaagcg 2853661 ttgatcaaat tctttccctg tctggcagaa aaattcgtac gaactgtcac caagcgccaa 2853721 aacggaaaag cgcaggtctt caagcttagg cgcccgtctt ccgtgcagaa attcatgaaa 2853781 cgacagcgcg ttatcaggcg gctcgccttc tccatgcgta ctgacgacga ttaaaagatt 2853841 ggttaccttc ttcagctgat tcggcttaaa atcgctcatg gatgagacgg tcacttgaaa 2853901 accgctctgt tcaagctgct tgccggcatt ttctgcaagc ccctgtgcgt ttcccgtctg 2853961 tgaaccataa agaacggtca cttcttttga aacggccggt gccggtgctt ccgctgacac 2854021 agctgccgcc ggcgtacccg cagcttcttg ggcggaaaca gattgagcgg ataaatatcc 2854081 gctcagccag attttctggg attcggtcaa ggtcggcaga aggcggttaa ggagctctgc 2854141 ctgctcctga ttaaacggac tgttcattac ctgaagttgc aacgtatcca cctcacaaag 2854201 ttataaactg atcgaaaatt gcatctaatt gaactttacc ggaatactag gcttaagtaa 2854261 aatatattta catgatgata actattaaga atcctaatga taaaacggct atgcttcatg 2854321 taaatagaaa aaagagaagg actcccttct cttcattcag caatctgata taagtgaggc 2854381 ggcacagcgg ttacaaacgg actggcttca cctgtataaa ataccgccag catgtgcatc 2854441 gcacgggtgc acgcagtata taaaagcctg cggtcgtgct ctgtatgata gtgttcttca 2854501 gatgcatcat agacaagcac tgcgtcaaat tcaattccct tcgctaaata caccggaatc 2854561 acgcaaacac ccttttgaaa tggttgattt tctttatgaa tcaggcgaac atctgtatat 2854621 tcactcatgt gggcgtgcgc ctgtatgcat tgatgcgcag tcttgcagat gacggctatt 2854681 gtttcgtgcc cttttttctt gagccggcca atttcttgcg cgagcttttg gcaaaggctc 2854741 tcatgtcctt cagttttgac aacgagcggc atttccccgc ttctattaaa cggctcaata 2854801 tccgctccat cttgaagcat cgctttggta aactcgacaa tctgccttgt tgatctgtat 2854861 gttctcttta aacgaacata ctcagcaggc tcatcctcaa agcacgcatc catacgctga 2854921 tccccgttta tggtatgcgc gtagatggac tgattgatat caccgagcac tgtcatgctg 2854981 gcagccggaa aaatgcttct catgtaagcc atctgaaacg gtgaatagtc ctgggcttcg 2855041 tcaataaata gatgtttgat tttcgtattt ttctttctgc cctcaatcag atcctgcata 2855101 taaagaaacg gtgccgcgtc ctcatagagc aatttattat ccgtaaatgc cgaacgggtc 2855161 agctcaccta tcgcatccat cttctcatgt tgaaattttc ctccccagcc agaaaacaat 2855221 tgcaaataaa gttgtgtaac atcaagaaat gcaaggagcc tgactgcctg tttgagcggt 2855281 ttgaaagctt ttttcacaat gatggcggca agcagctgct gctctctttg ataatcgtta 2855341 aacgtactct cgctgaaccg tttcctttcc tgcagttttt tgtacacgtc caagtagtcc 2855401 tctttgtcaa gcagctcagc ttcatgaaca acccaatcct ttcgccgttc ctttttctca 2855461 agcttgttaa gctcactcag cagccacttc gcggtttgct ccatccgatt cggaatggag 2855521 tgattttgat ccaatgagta aaaataggat tgaatttgct cctttgtgat cagcttttgt 2855581 ccgcggaata taatattttt aaaaatcatc ccttcagagg aaagccgtgt gacgtattca 2855641 ttaatgaatt gctgaaagga taaacccgcc ttccatgtga ttcctgcaag ccttgttgga 2855701 aaatcgcctc cctttgtttc ggtcaggcaa tattcgagct gatcaaaggg gctttcacat 2855761 ttgaacttgc ggccaagacg atgctcgata tattcctgaa acgtcgcctg ctccatattc 2855821 tcttctccta actccggcaa aacagaggag acatagctgt taaataagaa gttgggtgaa 2855881 aacaaaacga tttgtccggc atcaatgaca ccgcggtgcc tgtataacaa ataagcgaca 2855941 cgctgaagcg cagccgatgt tttcccgctg ccagccgctc cctgcacgat caggatcttg 2856001 cttttttcat tacggataat ctgattttgt tctttctgaa tcgtagacac gatgtttttc 2856061 atttgggtat cagagtgatg gcttaatacc tcttgcagca tttcatcgcc aatcgtcata 2856121 tcggtattaa acatcgcctt gagagtgccg tttttgatca taaactggcg tttcagcacc 2856181 atttcccctt ctatcgtttc accgggcacc tcgtactccg cttttcctgg ggaataattg 2856241 tagtacaaac ttgatatcgg cgccctccag tcatagatca gaaagtgttc ctccttctca 2856301 tccaaacagg aagctaaacc gatataaatt cgctctgcct gctcctcgcc gttttcaata 2856361 aaatcaatcc ggccgaaata aggcgatttt ttcaattgat gaattcgttt gagctgctga 2856421 tccatgcgcc gatgattgtg ttcccgatca gacagcagct ctgcctgctg cttaatgcta 2856481 gccatcgttt caatcgcttc atgggcatca tcaaaattaa ccttaacatc ctcccaaaag 2856541 ctttttctta atccgatgat atcatgcttc aacccgcccg cagacgtttc cagaaaccgc 2856601 tctttttttt cgagctcctt cagcacctca tctattctcg actgctcttc cttccattcc 2856661 ttatcctgct gattcatgaa cggcacctcc agaaaatagt tgacaaacat agatgaaata 2856721 ctgtaaaata taattggata catatattaa atatatgatg caaactggca aatacaattt 2856781 ataatagcac attcacccaa taccaatcaa ggtttgggtt atttatatta tgcagaaaaa 2856841 aaccgatttc acttcgaaat cggttttttt gctattaatt atctaagcga aaagaacggt 2856901 ttggcagctt ccaattaaac atataggaac aaacccggca aacaacgagc acgaaaaaca 2856961 gaacgtataa gccgaacgag ttccccagcc agcccaagcc gacgattaaa ccgccgagcg 2857021 ccgcccatac cgcatagatt tccgctttca gcacaagcgg tttgcgcccg gcaagaaggt 2857081 cgcggatgat cccgcccccg cttcccgtca gcaccgcagc cacgatcacg gcactaagcg 2857141 gatggcccat tttgacggca tacagtgcgc cttggatagc aaaggcagcg aggccgatcg 2857201 catctgataa attgccccac ttattccaat gcttcagcag cagcttcgga aacagaaaca 2857261 caattgtaat agataaaagc gcgatttgaa agtacgctcc ctgctcccat agcgctgaca 2857321 ccggaacacc gatcagcaaa ttgcggatcg ctcctcctcc aaaagctgtg acaatcccta 2857381 atatataaac tcctaaaata tcatattcct cttccatcgc aacaattgcg ccgctgactg 2857441 caaacgcaat gatgccaatc acactaagca gctcccaagc cattctgatg actccctttt 2857501 atgtttgtta aattttctga cgacctctag attttataat cgctccagcg taaaatcaat 2857561 aacattttca tgagaaaaaa agataaattt agagggaata cggctattgc tgatggacat 2857621 gagtttgcga aattaaaaaa gcgcccggca tacgcgggcg ctttttttgt tattcagatt 2857681 tttcgccttt cagcaggcac ataaaaatga taatcaggat aaaagcaatc agggccagga 2857741 atggaatcgt aataaaacca aaccagttaa tatattggcc cgagcacggc acgccgctga 2857801 cacatggctt aatgccgcta aagccgggca ctttttgctc taagtaatgc atgatcgaaa 2857861 tgaatgcccc aataatcgcc atcgggagca catatttttt cactcgtgtg tccccttgaa 2857921 aggtggcgat gcctaaaatc aggacgagcg gatacatgag gatacgctgg taccagcaca 2857981 gttcacatgg aataaacttt ctgatttcac tgaaatacag gctgcccagc atagcgataa 2858041 gagccacaac ccaggaagca tataaaaata cgattctatt tttcatattg ttacttccct 2858101 ttcagctctt tttctattgt ctctttgatt tcatcataat ccgcaaaatt tttgatcact 2858161 ttatcattga cgtaaatcgt cggtgttgcc tgtatgttca ttttttgatt aaggtcagaa 2858221 tccttttcca cttgagaagc gaatgtttcc ttatcaagat tttccttgag cgtctcaggt 2858281 tttatctttg tggtgctttt tgcaagatca ccaaggaggc ctggggttac ccattcctgt 2858341 tccgtatccg gctgtttttc gaacagcttt tcatggaaat cccagaaaga gtcagggtct 2858401 tccttccata cttcttcaga tgcaagagcc gctaaccttg aaccttttcc atggaacatg 2858461 acgttcacga aagaaaattt cacatcgccc ttatcaataa agtctttttg tatttttgga 2858521 aagatgtcac tgttaaacac cttgcaagac ggacatttgt aatctccgaa ttctactaca 2858581 gttaccggtg catcgtcctt gccaagcaca ggctgccctt tgatagacgg ctgtccggac 2858641 accgcatcat tgccttgttc cgttttgtta ttaatgatga caatggctgc tagcaataca 2858701 acaaccacaa ccgtaaggat gaccgcgaat ttcgcagaag actgctgttt ctttttcact 2858761 ccgacacctc atcgttttaa aattaaaaaa gaagcggatc gcaattgacc cacttcttta 2858821 ttttaacaag acaagcgctg ataagaaaac cccgaaaaaa tgaattctct ccgacaattt 2858881 atttgttttt gagacgcatg acgcgcatgg cgttcgccac agcaagcagt gtaacgccga 2858941 catctgagaa aaccgcttcc cacatggtcg caattccaaa tgcaccaaga atgagaaaga 2859001 tcgctttcac acctaaagca aagccgatgt tttgccacac gattcgccgt gtccgtttcg 2859061 caatccgaat cgcttctgct atttttgacg gctgatctgt catcagcacg atgtctgcgg 2859121 cttctaccgc ggcgtctgag ccaaggcctc ccatcgcaac ccctatatct gcgcgtgcaa 2859181 gcaccggcgt atcattgatg ccgtcaccga caaaaatgag tttttcacta ggcaaaagct 2859241 tagcttctaa tgcttcgacc tgcgcgactt tatcttgcgg cagcagctct gcatatacct 2859301 caccaatccc aagctgtttt ccgacggctt ctcccgtttg tttcgaatca cccgtcagca 2859361 tagctgtctg tttgatccca agcgacttca gatcagcaac cgcctgtgct gcgtcttcct 2859421 ttatctcatc cgctatgatg attgctccgg catagcgttg atctacagca acgtgtacga 2859481 ttgttccagc attttcatcc gggacatcct caatttgttc tctttccatg agctttttat 2859541 tcccagcaag gatctcagtt ccatttacct ttgcaaaaat gccgtgaccg gagatttctt 2859601 cgtatgactc aatctcatcg gaggaaagca ttttcccgta agctttacgc acagattcag 2859661 caatcggatg ctgtgaatga agctcagcgt atgccgccgc ttcaagtaat ctatcctttg 2859721 taaaaccttc cgcgggtttg atttctgtca cttcaaagct gccttttgtt agtgttcccg 2859781 ttttatcaaa caccgcgtat ttgacttgat tcaaagcttc taaataattg cttcccttta 2859841 caagcactcc ggcctttgag gccgctccga ttccaccgaa gaaaccgagc ggaatagaga 2859901 caacaagcgc acaaggacaa gaaatcacta aaaagataag cgcgcggtac acccaatcgg 2859961 aaagcgcggc gccagaaaga acaagcggcg gaacaaaggc cagcaatacc gcaatgatca 2860021 ccacagcagg tgtataatac ttggcaaact tcgtgataaa gttttctgtc cgggctttac 2860081 ggctgctcgc attctgaacc aagtctaata tttttgatac tgctgattcc tgatagccct 2860141 ttgtgacttc aatatgcaga acgccgtttt gattgataaa gcctgacatt acatcttgtc 2860201 cttccgcagc ttttctcgga acggactcac ctgttaaagc agatgtatca accatcgctg 2860261 acccttgcac gaccttaccg tccaggggta tgctttctcc cggattaacc acaatgatgt 2860321 ctcctgtctg aacgtcctcc gacgaaacct gttcgatgcc gttctttgtt ttgagattgg 2860381 cgtaatcagg ccgtatgtcc attaacgcac taattgattt tctggaacgg ctgaccgcgg 2860441 ctccttgaaa aagctcaccg atttgataaa acagcataac ggcgaccccc tcagggtatt 2860501 gctgaatcag aaaagcgccg attgtggcaa gagccattaa gaaatgctca tcaaacacct 2860561 gaccgcggat gatgtttttg actgcgcgga ttataatgtc accgccgata atcaaataag 2860621 caccgaggaa aaggaaaaat tcaatggttc ccgactgaac caaatatgcc gctgcgccga 2860681 gaatgacagc cgccgccatt ctgatcagca tattgaccat tcgattacga tagccatcat 2860741 cagctgattt ctttatatgc ttttggcgaa ccgttacatg cggatcaatt gatttcactt 2860801 ttttctctac tttattcgtg acccattgct cttctttccc atcggctgag acagttaagg 2860861 tgcttgccgc aaaatttacc gcgcatccgt taatgccttt tatgcctttg actccatttt 2860921 cgatttttcg ggcacaattg ctgcaatcca aaccgtccag aacatattcc tgtttcacta 2860981 gtctcacctt accttccgat ttagggttcc ctcttcaaag cgtatcaatg agtattgtat 2861041 ttattttata tatatgagca tatactcata tataagttac acctattata tgttgttttc 2861101 caagaaagtg tcaatgaaaa acaaaaaccg gcatatagcc ggtttttcat tttacttttt 2861161 gcagacgaag agcattcaga acaacggaaa cggagctgaa tgccattgct gctcctgcta 2861221 tccacggtgc taaaaatcca agtgctgcga ttgggatgcc gaggctgtta tagccaagcg 2861281 cccagaataa gttttgttta atgtttttca ttgtcaatct gctcatgcgg attgcgtcgg 2861341 caatgctgtt cagatcgccg cgaataagtg taatgtctgc tgtttccatg gcaatgtccg 2861401 tgccagttcc aatcgccatg ccgatgtcag ctgtggcaag cgccggcgca tcgttaattc 2861461 cgtcgcctac cattgctgtc tggcggcctt ctttttgcaa gcgggcgatt tccgccgcct 2861521 tttgttcagg aagaacttcc gcaatgatat tcgcaattcc cgcttccttc gcgatggctt 2861581 ctgcggttct gcgattgtct cctgtcatca tgatgacatc aagacccaac tctttcagac 2861641 gggcaacagc cttccgcgac gtatccttaa tcgtatctgc aactgctact agccccgctg 2861701 cttctccatc aatggataca agcataactg ttttcccttc ggcctctagc tcttccattt 2861761 gggcgagaag agccccatgc tcaacctgtt cgctctccat taattttctt gtgccgacga 2861821 gaatgctttt tcctccggct tcagccaaaa tgcctgcgcc gacttttgct tcaaagcggg 2861881 taagtttcgg tatctcaagc cctttatctt tcacgccagc aataatcgct tcgccaagcg 2861941 gatgctctga tcccgtttcc gctgccgctg caaattgaag caaatctttt tcttcaaaac 2862001 ggccgaatgg aatggcatcc gtcagacgcg gcttcccgtt tgtcacggtt ccggttttat 2862061 caagaacaat tgtatcgaga cgatgtgttt tttctaaatg ctcgccgcct ttaaataaaa 2862121 tcccgaattc agcagcgcgt ccagatccag ccattatgct cgtcggagtg gcaagaccga 2862181 gggcgcaagg acaggcaatg acaagaaccg caatgaactt gctgatcgct tcggcaaaat 2862241 cgccaggagc cgcccaaaga taccaaatga gaaaagtgag aaccgcaatc cccaatacaa 2862301 tgggtacaaa aatgcctgaa atctggtcag cgagacgctg gatcggcgct tttgaccctt 2862361 gtgcttcctc aacaattttg atgatatgag aaagcgcagt atcctttccg acgttgacag 2862421 ctttaatttt cagaaagccg tttgcgttaa cggttgaacc tgtcacgctg tcaccaggat 2862481 ttttgtcaac aggaagactt tctcctgtaa tcatcgattc gtcaaccgct gaacggcctt 2862541 caaccacttc tccgtcgaca ggaattcgtt cgccaggttt gacgtaaaca atgtcattaa 2862601 caagcacttc gtcgatcggg atgatttgct cctgtccgtc tcttacaaca gtagctgttt 2862661 tcgcttgaag cttcatcagc tttttaatcg catccgagga acggcctttt gcttttgttt 2862721 caaacaactt gcctaataaa atcagcgtca gcaaaatcgc gcttgtttca taataaaggc 2862781 cgtctgtatg cccgtgagag ccaatgcttt gaaaagttag ataaagacta taagcgtaag 2862841 cagccgtcgt accgagggcg accaatacat ccatattggc gcttttattt ctaagcgcct 2862901 tatacgcacc cacataaaac ggccagccga tcagaaactg gactggtgtc gccagcgcaa 2862961 actgcatcca cggattgaga aatatatccg gtacccaaat gaatgatgta aatgtaaaat 2863021 ggctcaccat cgcccaaagc aatggaaatg acaggacagc tgaaaaaatc agtctcgccg 2863081 tttgcttccg ttcttctttc tttttagcag cagcctcact gtcctgttca cccttcaact 2863141 ttagcttata tccaagctta tctaccgctt ctttcaaatc gctgacagac gcttcttttg 2863201 gattgtattc gaccgtaact gtttctaaag cgaagtttac tggtgcattt gcgacgcctt 2863261 ctattttgtt aagccgtttt tcaatccgat tggcgcaagc cgcacaggtc atgccctcaa 2863321 tatcgaattc agctttttct gtaacgacgt gatagcccag cttctctatt ttttcctgaa 2863381 tcgctgcagt ccctgtttca gcaggatcgt agattacatt tgatgtttcc gttgccagat 2863441 taacatttgc atccgtgaca ccgggcatcc gcttcaggcc tttttcaatt ctggcagcac 2863501 atgccgcaca ggtcatacca gagacctgca tcgcgatttc cttttgttca ctcaacatac 2863561 tcactccttt atatacacct ggggggtata taaaaatgaa agaaatatcg cgcctcccta 2863621 aaggcgcgat accttgaatc acttggctac gtcatagccc tgatcttcta tcgcatccgc 2863681 aatatctttg actgatactt tgtcagcatc aaacgaaaca tcgactttac ccgcttccag 2863741 attgacatga acggcactga cgccgtccag ttctcctacg cttgtttcta ctgctttgac 2863801 gcagtgctga caagacattc cttcaacttg caatgttttt tgttccatat caattcctcc 2863861 tgtttattct ttctattttc atcctaccat acccccgtag ggtattacaa taaaaaacgc 2863921 tttatgattt tgtgaacttt ttaaatacgt ccaaaagctc agaaatggcc tgttccccgt 2863981 ctccgctttt gatggcatct gctacacaat gatgggcatg atcctcaagc aaatgaagcg 2864041 ccacattttt cattgccgcc tgaacagctg aaatttgcac aagaatatct acacaatatc 2864101 tgtcgttttc caccatgttt tgaatgcctc tgacctggcc ctcaatccgc ttaagccggt 2864161 ttgtaatctg atccttttct ttcgagcttt tatggtttaa tgttttatgt tcgttatgct 2864221 tttccatgcg tacacctctg tttaatgata ttaattccca ttatactgat tgtccaaacg 2864281 gttgtctaag catgccgacg caaaaaatga atcagttagg ttttaccatt tgatcaggag 2864341 ggtatatact tctgttgata acgcttttaa aggggagaag aaaagtggat acgatcaagg 2864401 ttggaatatt aggatacgga ttgtccggtt ctgtttttca cgggccgctg ctggatgttc 2864461 tggatgaata tcaaatcagc aaaatcatga catcacggac agaagaagtg aaacgggatt 2864521 ttccagatgc tgaggttgta catgagcttg aagaaatcac aaatgaccct gccattgagc 2864581 ttgtcattgt caccaccccg agcggccttc attacgagca tactatggca tgcatacagg 2864641 ccggaaaaca tgttgtgatg gaaaaaccaa tgacagcaac ggccgaagag ggggaaacat 2864701 taaaaagggc tgccgatgaa aaaggcgtat tattaagcgt atatcataac cgacgctggg 2864761 ataacgattt tttaacgatt aaaaagctga tctctgaggg atcccttgaa gatatcaata 2864821 catatcaagt ttcctataac cgctacagac ctgaagttca agcgcggtgg cgggaaaaag 2864881 aaggcactgc cactggtacg ctgtatgatc tcggctccca catcatagac caaaccctgc 2864941 atttgtttgg gatgcctaaa gccgtgactg caaacgtgat ggcccagcgg gaaaatgccg 2865001 aaacggttga ctattttcat ttaaccctgg attatggcaa gcttcaagcc attctatacg 2865061 gaggatcaat cgttccggca aacggacctc gttatcaaat ccatggaaaa gattctagct 2865121 ttatcaaata tggaattgac ggacaggaag acgcactcag agcgggaaga aaaccagagg 2865181 atgacagctg gggtgcggat gttccggagt tttacggaaa gcttacaacc attcgtggct 2865241 ccgacaaaaa aacagaaacg attccatcag taaatggctc ctaccttact tattaccgta 2865301 aaatagcgga aagcatacga gaaggtgctg cgctgccagt cactgctgag gaaggtatta 2865361 atgtcatccg catcattgaa gccgcgatgg aaagcagtaa agagaaacga accattatgc 2865421 tggagcacta aaacaaaagc ctccccaaat aaggggaggc tttttcatta gaatgttttt 2865481 cctgcttctt tcgcacgcgc aatcgcgtct tctttgattt gctgtgcttt atcaggctcc 2865541 gcattatgtc cctctacgaa aatgccatcg aatgatggta cgccgaagaa gttcatcatg 2865601 atgccgatgt agcggtgccc catttccatc tcagccgcag ggccttctga atagtagccg 2865661 ccgcgcgctt ggatatgaat tgctttttta tcagttaaca agccgacagg accttgttct 2865721 gtgtatttga atgattttcc tgcaacagca acagaatcga gatacgcttt catcactggc 2865781 gggaatgaga agttccataa aggagtaaca aatacgtact tatcagctga tgcaaattga 2865841 tcgctaagct ctcccaaacg gcctactttc gctttttcgc tttcagaaag ctcttcaaag 2865901 cctgtacctg actgaagctt tccccatccg ctaaatacat ctgcgtcaat gtgcggaatg 2865961 ttttctttgt acaaatcgat atgtacaact tcatcatttg gattcgcttc tttgtaagat 2866021 tcgataaatg ctttacctgt tgccatactg tacgaagttg cttcgtcatg tggatgagca 2866081 gtgatatata atacttttgc catttttacc agccctttcg tttttaaaaa tcacacatca 2866141 attattatca tacagatgca taatgattat tctgtctctc ttagacttta ttatagagac 2866201 aaagaaattt actttcaagt aaaacatctc gaattaaaga ttatttaact ttcccaaaca 2866261 gcttactttt caaaagctgt tctcaagccg gaatacagcg cggacaattc tttactgatc 2866321 cgaggataat gagggacatg cggcacttga atatccgcag gcatcctttt catgataaag 2866381 gattgctcag cctgttcaaa aaacgcccgc agctggttga tctcttcatc agaaaacgga 2866441 gcagacggac ggcggtgagc ttgcgccgag agcaaatagt accctaagtg ctgagcaccg 2866501 gaaatggcag gccagagcgc atccgcattc gcgtgaggaa actcgccaag cgccttgtca 2866561 tacgcatccc gaagcctgac aagactcacc cttaacttgt gttcgtcggc aatttgcccg 2866621 gttaacagtt tctccataaa ctgcccttcc agccggatga cattccgcac aagttctggc 2866681 agccgcttgg ttgaaaaccg ccgccacaaa agcattgttc ccaacagccc gatcacgctg 2866741 ccgacagcta catcagtcag cctcgctatc ataaaataac cggcgcccgc cccgccatgc 2866801 atactttctg tgataacaag cgcatttgcg gttaaaaagg gaacagccag cgcataattg 2866861 cggacgatca gcatctcaag aagacattgc agcgctgcaa tacaaaacgc aatataaaca 2866921 ccgcccggct taaaaaacag gattgcgcct gccagtataa caccgatcac cgttccggcc 2866981 gaacgctgaa tagccctgtg aagcgtaaaa acaacagtag tgccaagcat gaccgctgct 2867041 gccgaaagcg gaatccaata ggagcgtgca aagccgaatg cgagggcaaa catatcggcg 2867101 gcaaacagaa caattccgta ctttaacgct ctaatcaaaa ctggagactt ccagtcaaag 2867161 gcatttctca aaaagtaaaa agaggatggc aggcggcttg gttccccgtc aagctgctta 2867221 tcaaaacgtc ctgaagcgat atacaaaacc tcattgattt cttcaaacag cttccgccta 2867281 ggctcagatt cattttcatt aatctgaaac gtattgaaaa cccgtgcatt cgcaagcata 2867341 tctccggttt ggcgaagtgc cttttcaatc tgcgcggtct ctctgtccgg cgtttcagct 2867401 gaaaaatgaa taatggcaat aaatatgtcg tcagctttct caaggaggcg aaaaaatcgt 2867461 tcatcatgcc gcgatttttt ccgtctgttc cctttcccaa gaaccgtttg gcgggctgtt 2867521 ctaagcatga gcaccgtctg atgctgtgcg ttatgaaaac ctggcgttcc gacggctgaa 2867581 agacatgcag ccagctgatg atatgttttt tgcagcaccg ctccctccgg tccatgtttg 2867641 ttccataacc agccgattaa agcgataccc atggcgaaaa tgccgccgag aaacgtcagt 2867701 cccgctctga acagcgcttg tgaaggatcg gccggcagcc cggaactgac taaaaaggca 2867761 aggacaaaaa acatcggcgc agggccttga atgccgagcg cgctaaaaat aaacatcgcc 2867821 gctgcaccga tcagccccaa aacagccgcc atcatccaaa gcatcccgga caaaagcgtc 2867881 cctaaaccaa atgagagggc gatcccaata gaaaccaaga gcagcttcaa ggcgcgcttt 2867941 ttgtacgatt caccgcccgc atataaataa acaaagcctc cgatacttgc aattaatccg 2868001 taatccgtgt gacctgccaa tgcaccgacc agcacaggaa accctgaagc gaaacctgat 2868061 ccgatagcct ttttccaagg aaatggattt gcatgaatgc gaaaggcatc cttcacgata 2868121 ggcatgattc tttgattgtt cgcagcagtt ttgttcattt gacaaaatcc ttttcaatga 2868181 atgtgtagaa cttttccagt ttcttcgctt tagtatgccc aaaaacgcgg ttagcttctc 2868241 aattggtgcg cacgataaaa aaacagagac ttataccgtc tctgcttcat tacatcagtt 2868301 tattataaaa gcggcacctg tcaggactgt tttgtccttc tgccttcctt caagagcagg 2868361 tgaataaaaa ataaaggata aatcaataga tacccattaa acagccacca cacaagatca 2868421 aagtcactgc tgaatgtcca gaatgatagc gcctgcagac ctgaacaaca ggtcagcaca 2868481 agagaaatca gcgccatcag cttccagtca gcacgattca cccgctgtag gtacaagctg 2868541 tacaaccctg tgacagaaat caggatatcc agcggaaaaa aagaccagtt ccaagcgatc 2868601 ataaacggat ggtcatgatg tttaaaagcc cagctttccg gtatgagcga aaatccggct 2868661 gacagccagt acaagataaa accgatatca gtcacgagaa aaaacagctt catatatctc 2868721 atttgtactg cccgctttta tgtaccggct cagacaccgc aacatgctcg atcaggttta 2868781 aagacacaac accggcaata atcaatccaa ttgaaatgac tttcatgaca ctcacatgtt 2868841 cttgaaaaaa caaaaaacca acgactgtaa tcaagacaat tcccatccct gaccatacag 2868901 cataagcaac tgatacatca atggatttaa gcgtaagcgt cagaaagaaa agactccctc 2868961 cataaaagaa aatcaacagc aaactgggaa taagctttgt aaaaccagac gatagcttca 2869021 tgctgacagt tcccgcaacc tcaaacaaaa tcgccaagca tagaaacacc caattcatgt 2869081 ggcatcagcc tcctcatcag ctgttatacc gttaaacaaa acatctacaa ttgattcaag 2869141 tacctctcct gtcgtgaact gatgtttcag cggatattca gggtcataca cttgattgat 2869201 gctccctata tacatgtgaa caaacaggtc cggattgatg tttctgattc tcttttgctg 2869261 tttgcactca tttaataatg ctaggacaat cgcccattct tccttaataa acgcgtctaa 2869321 tgtaagccac gcatcgtaat ggtatttctt tagttcattt aataatccca tgttcagcag 2869381 ttccatcccc tgcggaaggc tgatcagcat ttgtttcacc ttttcgagca catttaaact 2869441 ttcattttca tagatgtctc tttctatttg cttcatttca gctataaatt gttcgacaac 2869501 cgcctcaaca agctgatctt tagatgaata atatgcatag agcgtccgct tgctcgttcc 2869561 cagcgctgcc gccaaatcat tcatcgtaaa tgaaaatcct ttctgcttga tcagccggaa 2869621 ggtttccgcc agaattcttt tatccatatt aatcccccgc tttcggtacc aagaaaacta 2869681 tttcggtacc aatattatac ggcagaaatt tatggaaatc aacaatatat aaaaaaacct 2869741 ctcctattgg gagaggttta aaagacactg cggaccaaac cgccgtccgc ccgaagtgcc 2869801 gcgccattga tcgcagagga aagcggactg cttaaaaatg taacgaagtg ggcgatttct 2869861 tccggacgga tcagtctttg aataatagat gtcggccggt tttctttcat aaaacgtgcc 2869921 tcagcttctt gaacagtcag gttttcacca ggatacagcg agttcagcat ggtttccaca 2869981 ccctctgtta aggtagagcc cggcatgacg gtgttgactg tgacattcgt gccggttgcc 2870041 agctccgcca aactgcggga aatggacagc tgcatcgttt ttgtcgcact gtaatgggcc 2870101 atttcctgtg acggcataat cgccgcttca ctggcaatga aaatcacacg cccttctttt 2870161 ttctctatca tgttatgcaa atacctgcgt gtcagcctta caccgctcat aatattcact 2870221 tcaaaaaaac gaaaccattc atcgtcggga atatcaaagt actccgccgg ttcaaaaatc 2870281 cctaaattgt tgaccaaaat atcaacctct ggatatgcct gaaacagctc attgcagcct 2870341 tcttctgttc ccaaatcaaa tgcagccgga taaagaaccg cttcagcatg ttgtgttttc 2870401 agttcatcta tcgtttgatt cactttctct tcccggcgtc cgttaatgat cactgccgca 2870461 ccttcttcag ctaacgaaga ggcaatagct tttccgatcc ctgatgtcga accggtcacc 2870521 agtgcggttt ttccttgtaa attcagcttc attattcatc cctccgtttt tgattcctct 2870581 tatttattga cagaaatctg attggtgaaa catctgctct gcaatcagta tgaaacagct 2870641 gggattgaaa tggaagtacg cactttttgg tgcctgtggt ttggagaaaa aataaagcag 2870701 aacctcttaa gaggttctgc tttattgtca gtatgtatgg agacggtggg agtcgaaccc 2870761 acgtccagaa acatcgatta cttaagcgtc tacgagcgta gcctgcatat ttatggtttc 2870821 actcatcttc ttgcctgcgg gcgggccttc cgagagctag tctgttcatc tcttcttacg 2870881 ttctcagacg ggaacgcaag cgtagcctac ttggatgtgc tcttcacaga cacataggca 2870941 atgtcaggaa gagctcgctg cgcttattag gcagctaatg ctacgttttg gttaaaactg 2871001 ttagttttgc cagttatatt taagtgcgtg tttacgagat cgcctctcgg ctcgcagctc 2871061 aagctcgatc catccctgtc gaatccgtaa cgtccccttg gtataaggga aatacgggag 2871121 aaaatatcaa gctctcactc aaactggcta tagtcttatt ataacatgat cacggctctt 2871181 ttcaattgtc aaatccttca aatgaatggc gtcgtgatct gatcgtgaac acagtatagc 2871241 acaggcctga ttttcgaatc aagcactatg cctttagaag cctttttgac tgtctctgaa 2871301 cgctctttcg atttcccgct tcgcgtcctt gcgcttcaga tcttcccgtt tgtcatagtt 2871361 cttcttccct tttccaaggc cgagaagcac tttggcaaag ccgtttttta aatacagctt 2871421 cagcggaacg agagaatagc ctttttcctt tgttaacccg atcagcttat taatctcctt 2871481 gcggtgcatt aacagctttc ttgtccggag cggatcgtgg ttatagcggt ttccctgctc 2871541 atatgggctg acgtgcatat tgtggagaaa cacttctccc cgttcgattt tggcgaagga 2871601 atccttaagg tttacgcggc cggcgcgaat cgatttgatt tcggttcctt gcagaacgat 2871661 gcctgtttca taggtttctt ctataaaata atcgtggttg gctttcttat tttgagataa 2871721 tacttttcct gacccttttg gcatgccaga acctcctctc tctaaggaaa aactgtccac 2871781 cttttgcgat acgctctatt ttaccaaatg tcacgtaccg ctacaatgaa aagctgtttc 2871841 cgaaagaaag caaatagagc gctgcggccc tatttgctgg ttgagctgct atttcttctt 2871901 tttccgtttc tgtttcggag cattctggaa gccgcgtttt ttctttttct tcttcggctt 2871961 agtgaaccac tccccttttt cctcagacgg agctggagaa acaggtgtat tggtgctttg 2872021 aacacgtttt ctggcaggct ttccgcgttt tctgctccgg ctgctgtcca attctctcgg 2872081 acgccgcgga gtgcctttca tgccgacaat ttcaaagtcg atattgcgct catctttatt 2872141 gacatcgaca accttgactg tgatttcatc cccgatgcgg aagacgttgc ctgtccgctc 2872201 gccaatcatt gcgaaatgct gttcgtcaaa gcggtagtag tcatctgtca taaagctgac 2872261 atggacgagt ccttcaattg tattcggcag ctcgacgaac attccgaagt ttgtcacaga 2872321 gctgatcatg ccgtcaaact cttcaccgat tttatcaagc atgtattccg cttttttcag 2872381 atcatccgtc tcacgctcgg cgtcaactgc acggcgctcc atagatgatg tatgttcggc 2872441 gatatccggc aggcgttcag cccacttttc ctgtgtcgct tcatcgacct tgccgttgat 2872501 caaatacgtt cggatcagac ggtgaacgat taagtccggg taacggcgga tcggtgatgt 2872561 gaaatgcgta tagaattccg ttgacagacc gaagtgcccc aagctttgcg ggtcgtattt 2872621 cgcctgtttc atcgaacgga gcataacagt agatataacc gtttcctctg gtctgtcacg 2872681 cacagcgtcc agaatgcttt gcagcgcgcg cggatgaata ttccccgccg ttcctttcac 2872741 cacatagcca aatgtcgtca caaattctaa aaacttttgc agcttttcag cattcggctc 2872801 ttcgtgaatc cggtatataa acgggacatt catccaatgg aaatgctccg caactgtttc 2872861 gtttgctaca agcataaatt cttcaatcag cttctcggcg acagagcgtt ctctgatcac 2872921 aacgtcttta accgctcctt cgtcatcaac aagcaccttt gcttctttga aatcaaagtc 2872981 aacggcgccg cggtccatcc gcttatcgcg cagaatttga gccagacgct ccatgtcttt 2873041 gaacatcgga acaagaggct cgtatttttg tttcagctct tcatcatcat caacaagaat 2873101 tttattcaca tctgaatatg tcattctttc cgttgttttg atgacacttt ggaagatctc 2873161 gtgctctgtc acctgtccct gactgttaat tgtcatttca caagaaagcg tcaggcggtc 2873221 aacctttgga tttaaggagc agatgccgtt tgacaatctg tgcggaatca tcgggatgac 2873281 acggtcaacc agatacacac ttgtccctct ttcaagcgct tctttgtcaa tcggcgagtt 2873341 ttcggttacg taatggctga catcagctat gtgaacgcca agcttgtagc ttccatcatc 2873401 aagcttcgtc acggtaactg catcatccaa atccttcgca tccgcaccat caatggtgac 2873461 aatcacctgg tcacggagat cacggcggtc tttcagatct ttttcatcaa tcgtgtcagg 2873521 cgtacttgat gcctgttcca tcgcgtcagc tggaaattct cccggcaggc cgtgcttatg 2873581 aatgaccgat aaaatatcaa tgcccgggtc gtttttgtgg ccgagaatgg tttcaacctc 2873641 accctctgcg ttcatgcggc cttcaggata gctcgtcagc ttgacaacaa ccttatgccc 2873701 ttccgcagct ccatttttcc catttttcgg aatgaagatg tcactcgtga tttttttgtc 2873761 gtccggaatg acaaagccga agtttctcgt ttctgtatac gtgccgacaa cccgctgaat 2873821 cgctctttct aaaatccgta tgacggttcc ttcctgcctg gagccgcttg attgtgagtt 2873881 cagacgcacc atgacgatat cgccgttcat tgccgtattt agctcattag gcggaataaa 2873941 cacatcactt aacgacgtat cctcaggcag caaaaaggcg aatcctttcg catgggctga 2874001 aatctttcct tttattaaat tcatcttctc cggaatgccg tagcggtcgc ttctcgtccg 2874061 tacgataagc cctttttctt ccaaggcgac taacgctttg acgagctctt taaactcctc 2874121 ggcttccgta atatttaaca tctcctcaag ttcctgaacg gtcagaggtt tgtacgcctc 2874181 ttccttcata aacgagagaa gcttttccat aaatgcttct ttttccatta tccgacctcc 2874241 tgttgattac caatcgagct tctctaaaaa ttcatacaca tcctgatgga cgaggtcacg 2874301 ttctttgtcg agtgtaatga catgccctga ttcctcgtac catttcagct gtttatcatc 2874361 agtttccact tcgttgtaaa taatattggc gctttcggta ttaatcatgt ggtcatgacg 2874421 ggcctgcacc acaaatgtcg gtgaataaat catatcgaca ttattccgca catcagcaat 2874481 taagtcttgc agcgccttga gggtattcat cggcgttttt tcgaattctt tcatttcctc 2874541 ttcaatttgc tccgggcttt tcccctcaaa ctttttgtaa ttgcgagcgt atgaaagaac 2874601 gccttgatac atgacctctt cactcttaat atgcatcggt gcgcacattg ggacaattcc 2874661 ctttatgggt acagtgtaac ccaatttcag cgaaaaaacc ccgccaagcg acagtccgca 2874721 ggcagcaatg ctctcataac cttcagattt taaatattca tagccatcca ttacgttttt 2874781 ccaccagtct tcgggccccg tatgtacaag ttcttcaggc gggacgccat gtccttcata 2874841 ttgaggcgcg tggcacgtat agccgcgttc attcaaatat cgtcccagca tccttacatc 2874901 cgctgtattt cctgtaaagc catgcagcaa aagcaccgct ttgtctccgc ctttaaatgt 2874961 aaatggtttt ggtgtcacaa ctttcatgct catgtctccc tttctatctg cacgatcatt 2875021 ttagttttcc acagtttaat cagaaaaaaa cgttttgaat atcatccaga aacgtgaaaa 2875081 aggcctgact tcacatcaga ccttatacaa acattgccct ataggatata agcaagcgca 2875141 atcgttaaca cgaaaaacaa gactgccagc actaccgtaa tgcggtgcaa aattaaatca 2875201 agacctcttg ctttttgttt cccgaagagc tgctccgctc cgcctgaaat cgcaccagat 2875261 aatccggcac ttttactgga ttgaagcaaa acgacaataa taagtgcaat gctgacgata 2875321 accaataagg taatcaaaac tgcgtgcatc ccatacacct ccagactcac tggctacatt 2875381 acttctattt tacatgaaaa gggttggcat gtcacgctgt atcagacgcc aaaaggccgg 2875441 ataagacgtt ttatcttggt taccctattc atatgaaaag gtcaaaggag aaaagcgatg 2875501 ccgcttatca gcatagacag caggaaacat cttttttatg aagaatatgg acagggaatc 2875561 cctatcattt ttatccaccc gccgggcatg ggacgaaagg ttttttatta tcagcgcctt 2875621 ctatccaagc atttcagggt gatttttccg gatttaagtg gccacggtga tagtgatcac 2875681 atcgatcagc cagcgtctat ttcctattac gcaaacgaga tcgcgcaatt catggacgct 2875741 ttgcacattg ataaagctgt gttattcggg tattctgccg gaggcttaat cgcgcagcat 2875801 atcggcttca cccgcccgga caaagtgtca caccttattc tgtccggcgc ctaccccgct 2875861 gttcataacg taatcggcca gaagctgcac aaactgggaa tgtatctgct tgaaaaaaac 2875921 cccggtttgc tcatgaaaat cctcgctggc agccacacaa aagacagaca gcttcgcagc 2875981 atattaacag accatatgaa aaaagcagac caggcccatt ggcatcagta ttatctggat 2876041 tcgcttggct acaactgcat tgaacagctg ccccgcctag aaatgccaat gctgtttatg 2876101 tatggcggcc tgcgggactg gacctttaca aacgcaggct attaccgaag atcgtgcaga 2876161 catgccgaat ttttcagatt ggaatatcag ggacatcaat tgccgacaaa acaatggaaa 2876221 acgtgcaatg agctggtgac agggtttgtg ctgacacatc attcatagga atagaaaacg 2876281 cttggcttcc ttgcgttttt tgttacttta ttgacttttg tcaacgaaat catagtaaaa 2876341 aagatcctca aatttcaaat taaaatagtg aagcatttta ccaatcacaa gctgccccgg 2876401 ccttctttct ccattcagca cgcggctcag tgtggcgggt gagactccga tttccagcgc 2876461 aagctgatta agggaataat cgttattaac catatactgc aagacataat cacgtctaat 2876521 ctgtatcttt tctactggca ctttcctcac cttccattcc tgaaaaactt ttttctatac 2876581 ttttacatta cggcttatgt taacttttgt caatacattt ccagtctacc tattcccttt 2876641 agtcaataaa catactaaaa tatgagtaac agtgagggac ggggtgagat atatggaaag 2876701 ctttggcgaa caattacggg cattgcgtga agagagaaag ttaacagtca accagctggc 2876761 gacttattca ggcgtaagcg cggccggcat ctccagaatc gaaaacggaa aacggggcgt 2876821 tcccaaacct gccaccatca aaaaactggc agaggcctta aaaattcctt atgaggggct 2876881 tatgtacaag gctggttaca tcgaagaagt gcatgaagcc agggcccctt atgaaacgaa 2876941 gtgcaagctg cttgaaaaag cggaggccta tgacctgaaa aaccttgcgc ttcttgagaa 2877001 cgaaaagtgg caatatctca ataaagaaga tttgctcatg ctggatcatt atttttcgtt 2877061 tatttcagat gaagcgaaaa aacggtctgc tgatgactga ctcttgatag aaatgtgagg 2877121 cgatagacca tgtcaccgtt cggacagcaa ttacgggagc tgcgccgcgc ccgcaaactg 2877181 acagtgaatc agcttgcggt gtactcaggc atcagctcgg ccaccatttc aaaaattgaa 2877241 aacggcaaac gcgggacgcc aaaacccgcc acgattaaaa aactggcagc cgtcctgaaa 2877301 gtgccgtacg aaaacctaat ggccgccgca ggccatattc aggcctttcc tgaagaaatc 2877361 cgcgaagcat ctgaaggcta tcaatccgtt tatgaaattt accagacggc tgtcacacgc 2877421 ggagcggagc acctcccgat tttcaatagt caaaaatggg aacatctctc aaagcaggat 2877481 attgaaaatc tcagcaaata cttcgatttt ttgtcttcag aagcaaaaaa acgcgcctct 2877541 tcctcataat cccctgtttc tctttctata ttttatcaat cacgcttgca tgccctccct 2877601 cgttatttgc gttataatag tgacagacga ggtgaaaagt atgaaccaat cagaaatgtg 2877661 tcctagattt gaaaaagcag tcgacatctt aagtaaacgc tgggtcgctt taatcgtatt 2877721 tcagctcttg aacgggtcgc agcgatttag cgaaattgaa gcagcacttc caaatctaag 2877781 cggcagagtt ctgtcagaac ggctgaaaga acttgagctt gaaggagtag tgaagcggga 2877841 tgtcatccct gaaactccgg ttcgcatcga atattcattg actgataaag gaaaggcact 2877901 agcacccata ttaggtgaga tttctaaatg ggcgactgaa tggattgacc cttcctttct 2877961 tgactaattg ctaaaatggt tctgatctca aagacgagaa aagaaccgtt ttttattttc 2878021 caggtgaaaa aaagatatct cagccgatat atagtacatc cacacattac gtttttaaag 2878081 gagaccacta tatgcgactg acgatttccc gcaaattcag cctggtattt ttgacactga 2878141 tcctgatcaa tttacttgta ggcggaatag gcgttcttaa tatgcagcat atcattcaaa 2878201 aaacagatga aatcaacaca aaatggattg acggcatcaa aggaatcact tcaattaatt 2878261 atgtaaccga gcacctgtct tctaaagaaa aggactttct gatttataca gacaaaagta 2878321 aaatggatac acttgatcaa gaaatgaatc aaatcatgga agacattaac caaaagctcg 2878381 ataactacga aaaaacgatc tccactgata aagagcagaa actgttcgag cagcttcaaa 2878441 ctaaagtgaa tacctatatg gatattcatg cgcaaattat cgaaagcggc cgcacgaatg 2878501 acatggacaa agcaagaggt ttattggttc agactgaggc cagctttgag gatatgaaaa 2878561 aaacaatcac tcagcttgtt gacttaaatc aagaaggcag caacacagcg gtaaaagaaa 2878621 cgaaggccgt ctatcataaa gggctcattt acactgcttt gcttgtggca gcatcaatcc 2878681 tcatcagcat tttcatctgg ctttatatca cgcgaaacat tgtaaagcct atcattcgca 2878741 tgaaggaatc tgccaatcat attgccgaag gcgatttgtc gaacgatatg gaggccctca 2878801 actcaaaaga cgagctgggt gatctgaatg aagcgctgca aaaaatggta gggaatctga 2878861 gagatattgt cggatattct aaagacatat caagccgggt tctttcttct tcacaggtgc 2878921 ttgcaaccgc aacgaatgaa acaagatccg gcagcaaaca tattaccgag acgatgaacg 2878981 aaatggctga gggctctgaa cagcaggccc aagacgcggt gacgattgcc gaatcgatga 2879041 atgagtttac cgaaagcatt gataaagcct ataatcacgg catcacaatc agcgatacgt 2879101 ctcaaaacgt tctcgaactc gcggtaagcg ggaacgaaaa tatggctacg tcattacagc 2879161 aaatgaaaac catccatcat attgttgaag aagccgtgca taaagtgaga tcactggaac 2879221 agcattctca ggatattaac aagctcgttc aggtcatcaa cgggattgcc gagcagacga 2879281 atttgctgtc ccttaacgcc gcgattgaag ctgcccgcgc tggagaaagc ggcaaaggct 2879341 tcgccgttgt ggcagaggag gtcagaaagc tggctgacgg cgtttctgat tccgtgcagg 2879401 acattacccg gattgtaaac gggacacagc aggagatcca cactgtcatt acgtacttgg 2879461 aaagcagctt tacagaagtc gaaaaaggaa cggaaaacct gacagacacc ggacaggcta 2879521 tgcagcatat caaacaatcc gtcacccatg ttgcagacag cattaaggaa gtaacggatg 2879581 gcttgaagca gttaacaaac caatcgatta ccatcaatca atcgattgaa aatatcgctt 2879641 ctgtatccga agagtctgcc gccggcattg aagaaacatt ttcaattacc gagcaatccg 2879701 cccattcgat ggatcaagtg cttctaaatg ctgaagagct tgagcagctg gccaatgagc 2879761 ttaatgagaa gatgggtcag tttacgattt aaagagaaaa aagaggctgg actccagcct 2879821 ctttttctat tctatgcagc tgattgaaca tgtttcgccc cggttctttt tttcttcacc 2879881 ggacttaatg cccgctccag ccaagccatg agcaaatccg cccctaccgc catcaccgca 2879941 gttggtatcg ctccggctag aataatcgca gttccgtttg ttgcgtttga gccgcgtacg 2880001 atcatgtccc caaggcctcc ggcaccgaca aatgtgccga tcgctgtaat tccgatggca 2880061 atgacgagag ccgtgcgaag gcccgccata atgacagaaa gtgcgagcgg gagctcaacc 2880121 attctgagca cttggaattt cgtcatgccc attgcttttc cagattctaa gtaggcatgt 2880181 tcaatactga taatgcctgt gtacgtgttt cgaataatcg gcagcaggga atacagaaat 2880241 aatgatagaa tcacggtatt tgcgccgagc cccataacaa gcattaagac ggccagcata 2880301 gcgagcgccg ggattgtttg aataacgttt gttacggcaa acacccaggc tgacaaacgg 2880361 cgaaaatgcg cgatgaggat tccggccgga accccgacga cagcggcaaa taaaacgccg 2880421 taagccgaca tgagaaagtg gcggccgaat tcatccatga cgtaactgcc attctgcgcg 2880481 taatacgtca ttaactgttc aagcacgttc attgacctct tccccctttc acgattcgaa 2880541 atagcgatgt ttttctaaat attccttggc aacgacagac ggttctttga gattgccgtc 2880601 gacttcatag ttaagctcct gcatcgtggc tgtgtcgatt tttccgagca ttttcttgat 2880661 gatgccttca agttcaggat gttctttgag caccttttcc ggaacaaccg gagagcagtc 2880721 gtacggcggg aaaaattgtt tatcatcctt tagcattttg agaccatagg acttgattct 2880781 tccatcggtt gaatacgcaa gcacaatgtc catttttccg cttttcaccg cgtcgtacac 2880841 aaggccgatc tgcatcggat acgtgccgcc gaatgtcatg ccgtaggttt tcgtaaaatc 2880901 ctgatagccg tttcctttga gcttcatcca atagttatca acgcccagct ttaattgcgg 2880961 cgcccatttt ttaacgtctg atacggtctc taaatggtat tggtcggcca gctccttgct 2881021 gactgtaaag gcatatgtat tatcaaaccc gtaggagtca taccacttta aatcatatct 2881081 ttttttaaac tcccgctgag taagcgccag cgctttgtcc ggatcttttt caggttccat 2881141 tctcaacgtg cctgtcagcg cgtctcccgt atatcttgtg gccgcaatgt cgatttcccc 2881201 gttcattaaa gcctgctgct gcaccgcgtt ggagccaaga tttttaatcg ttgttgtttt 2881261 gagatcagta tggtgttcga tcaactggcc aagcatgctg gcgatgattt ctgattcgct 2881321 catgctttgc gcgccgattt taatggtctg gtctgcagca gcgctgagac caggaagcga 2881381 acagccgctc agcgtcagcg ttgccgcaag tgctaaacct atcattaatt tgagatattt 2881441 tcttttcatg agccgcctcc ttatgacaat tccttcaatc tctgcatgcc ggcaggtgtc 2881501 agttttcgtt cagcaactgc cagcacataa tcaatcacaa ttgccaatat cgtgacaggt 2881561 accgcgcccc cgatgatata ttccggctga tataaattca gtccgataaa aatgtaatca 2881621 cccaatccgc cgcctccgat aaaggaagca agcgtggccc agccgattaa gtaaatcgtc 2881681 gatgttctga ttcccgccat gatcactggt gcggcaagcg gcagctccac caagcggact 2881741 tgttcagccg gcgtcattcc tattccttta ccagactcga gcagattttt gttgacgccg 2881801 cgaatgccgg tatacgtgtt gcgaagaatc ggcaatacgg aatagaaaaa caaagccaca 2881861 atggccggaa ccttccctac accaaggagc gggataaaaa aagcgaggat ggccagactc 2881921 ggcagcgtct gaatgatatt gacaatgccg ataatggtgc cggctccttt tttcattctg 2881981 gtaagcacaa ccccgagggg gacggcaacc agcacaccta agatcacagc aatgagcgat 2882041 atcgtaatat gctcgtatgt tttataaaga agctctcccc cattggtttg caaaaattga 2882101 acaatatgat gcatgactta tcgcccctcc ctatgacaat gctgcgagct gcttttcttc 2882161 tccccagagg gagtcataca cgatgtcgac cagacttgcc ctcgtcacaa ttccgatcag 2882221 gcgtcggtct tcatccacaa cgggaacata tttgacaccc cgttttaaaa ttttgcggac 2882281 cgtgtcgcgc agcagtgtgc cgcccagtac tgtgtatata tcttcatgta aaacttcact 2882341 gacgagattg gcctttttcc ggcattgatc aatgatttca acatcgacat agccttgcag 2882401 aacgcgctcg tcattgacga ccagcaatga atcgacccgt tcctgcctca tcagctgaat 2882461 ggcctcagaa agcgttttat ccgcggtgat cgttacaggc tgtgtgttca taatctggtc 2882521 aacccgttca acatccgggc tggatgactg aatcagccgc tccttgccga taaattcctc 2882581 aacaaattcg tctgccggat ttcttaaaat gtcatcgggc gttccaactt gaacgatttc 2882641 tcccgctttt aaaatcacaa tccggtctgc cagcttaatc gcttcatcca tatcgtgggt 2882701 aacaaatacg atggttttat gtaaggtttt ttgcagtttt ttaaattctt cctggaggga 2882761 atccctcgta atcgggtcga gtgccccaaa cggttcatcc attaagataa gcggcggctc 2882821 cgcggcaagt gcccgtaata caccaattcg ctgctgctgc cccccgctta attcatgagg 2882881 gtaacggtct acatattctg gccccatatc gaccaatttt aaaagctcac gcgcccgctc 2882941 tttccgctgc tgctccggcc atttcagcag ttttgggacg agtgagatat tctgctgaat 2883001 ggtcatatgg ggaaacaggc cgatctgctg aatcacatag ccaattttgc gcctgagctc 2883061 tacaggatcc tggtccatga tgttttcgcc gtcaatgaaa atcttcccgg cggaaggctc 2883121 aattaatcgg ttaatcattt tcattgttgt cgtttttccg cagccgctcg gcccgataaa 2883181 gcagataaat tcgccttttg caatcttaag atttacgttg ttcacggctt ttttgccgcc 2883241 cttgtatgtt ttcgagacat tttctaatgt cagcaaacat cgcacctcca aaattaagtt 2883301 tattcaattt gttcagttta aatttaattt ttcagacaat tgaatgcttc ccattataga 2883361 ataaagttta taaaataaaa agtttacaat ttgttcatat tatttataaa gtatgtgtaa 2883421 acgctgattt acccgcattg acgtgtgttg atctccttat tgctccaatt tcctgccaaa 2883481 ttctcttttg acagcatttt cgccgtatca aaaatgtggt atattgacat cggaattgtt 2883541 agctgaaagg atgaaaccgt tggagaaaga tccgttaacg atcattgaac aagccgagga 2883601 ccattttata gaaagaatcg cggaaaacat gcatgcattt ggaatgccct ctaccgtcgg 2883661 acgagtgctg ggcattattt atatgaatcg aaaaccgatg acgcttacgg aattatctga 2883721 ggccaccggc atgagtaaaa cacgtatgag ccaggtagtg cgggaaatgc ttgatgccaa 2883781 cattgccgag aaggtattcg aaaaaggcgt gcgaaaagat ttatatgagg ttgagcagga 2883841 ctactatcaa acatttatca cgctgttttc agccacctgg agcaaagtcg tcagcaaaaa 2883901 caaaatgatg cataaaaaac tcaatcggga gctgcttagc gtgttggatg aagagcttac 2883961 tcctgaagcg gaagaaaaag tgaatgagct gctgaaggaa ttaaaggaat ggctcgatta 2884021 ttataattgg ctcagccgtt tgattgagtt ttttgagagc gaagacattt ttaaatatgt 2884081 gccgaagccg taaaaagttc ccaaattcaa ttctgggaac ttttttaagt ccaatccaaa 2884141 tggttgaata tcaaacttcg agctcccaac gctggaaaat atgtttaaca gatactaaca 2884201 catgttgttt atttaaaaaa accacctctg ttgtatttaa atagaggtgg tttttctatc 2884261 agctataata aaatttcctt ttttcttttt aatcgggctt aatgctcgtt caagccagcc 2884321 catgaccaaa tcggcaatca ccgccatcag agctgtgggg atcgctcccg ctaatataat 2884381 cgcggttccg tttgtggcgt ttgatcctct gacgatgatg tccccgagac cgccagcacc 2884441 gacaaatgtc ccgatggccg taatgccgat cgcaatgaca agcgcggtgc gcaggccggc 2884501 cattatgaca gaaagcgcaa gcggaagctc gaccatccgc agcacttgaa attttgtcat 2884561 ccccattgct tttcccgatt caagataggc gtgctcaata ctgataatcc ctgtatacgt 2884621 atttctgata atcggcagaa gagaatacag aaataatgac aatatcaccg tattagcgcc 2884681 cagccccatg acaagcatca gcacggcgag catggcgaga gccgggatgg tctgaatgac 2884741 attcgtgacc gcaaaaaccc atccgcttaa tcttctgtat ctggctatca ggatgccgag 2884801 cggaattcca acaatggcgg caaataaaac gccatacacc gacatcagaa aatggcggta 2884861 aaattcctgc agcacgtaac cgccgttttg cgaatagtat gtgccaagct gctgtagtac 2884921 ttccatatga tccacctctt ttcttagtca aaataatgat gtttctctaa aaattccttt 2884981 gctacgacag acggctcctt cagcttgcca tccacctcat aattaagttc ctgcatcgtt 2885041 tccgtgtcga tttgcccaat cagcttattg atcacacctt caagttccgg atgctcctta 2885101 agcacctttt ccggaatcac cggtgaacag tcatacggcg gaaagaaacg cttatcgtct 2885161 tttaagattt tcagatcata tgctttaatc cgtccatccg ttgaataagc caaaaccgca 2885221 tccattttcc cgtttttgac tgcgtcatag actagcccga tctgcattgg ataagttgtg 2885281 ccgaactcaa agccatatgt gctgacaaag cctttatacc cgtcgccttt tcgtttcagc 2885341 caagcattgt cgacgcctaa tttatattgg gaagcatttt tcttcaggtc agacacggtg 2885401 ttaatatgct ccttttccgc aaactttttt gttacggtga aggcatatgt gttatcaaag 2885461 ccgtaggaat caaaccattt ataagaaaag cgcttttgaa actcgttctg cacaatgttc 2885521 agcgcttttt tcggatcttt ctccgcttcc ttgccgaggg tgcttgttaa atctgttccg 2885581 gaatagcgcg tggctgaaat atcaatgtca ccgcccagca tcgcttggtg ctgaacatag 2885641 tttgagccga ggtttttcac taaagcagta ttcaaatctg tatcatgttc aataagctgc 2885701 gcgatcatat tcgctacaat ttctgattct gtcatgctct gcgccccgat tttgatcgta 2885761 tcgtcagaag cgccgcctag acccggcaga gagcagccgc ctagcagcat gacaaagacg 2885821 agagcaaacg cgccaagcca tttgattttt gtcattttca acagtgccaa ctccttacga 2885881 tacttccttc atcccttgca agcctttcgg cgtcaccttt cgttctgtca cagccagaac 2885941 ataatcaata ataattgcca gaattgtgac aggcacggca ccgccaatga tatattcagg 2886001 ctggtatagg ttcagtccga taaaaatata gtccccgagg ccgcctcccc cgataaacga 2886061 cgcaagtgtc gcccagccaa ttaggtagat cgttgatgtg cggatccccg ccatgatgat 2886121 gggaatcgcc agcgggattt caacgagccg aatctgctcc cagccggtca tgccaattcc 2886181 tttccccgat tccaggaggt ttttatttac acctttaatg ccggtatacg tattgcgcag 2886241 gatcggcagt accgaataga aaaataaagc gacaatcgca ggcacttttc ctacgccgag 2886301 aagcggaata aaaaaggcta aaatcgccag actcggcagg gtttgcacaa tgtttacgaa 2886361 accgataacc gcacctgcgc cttttttcat tctggtaaga gcaacgccga gcggcactgc 2886421 aacgataatg cccaatacaa cggctatgag tgaaatatat aaatgctctc ctgttttata 2886481 cagcagctct ccgccgttcg tttgcaaaaa agtcatcatt tgattcatct taaaagagct 2886541 cctcccctgg tcagatcgtc atgagctggt tttcctcgtc gccccaaatg gaatcgtata 2886601 cgatatcaac gaggctcgct cttgtcacaa tccctgctaa atggttctgt tcatcgacca 2886661 ccggaacata cttgatcccc tgcttcaaaa tttttcggac tgtatcgcga agaagcgccc 2886721 ctttttgaac ggtatatata tctgaacggt atacatcgcc aacgatgctc gcttttttgc 2886781 ggttttgatc aatcatttcc acatcaacat agcccttcag cacgttttgc cggtccacaa 2886841 cgagcagcga gtcaacacgt ttttctctca tcagctgaat cgcctgagaa agcgttttgt 2886901 ccgcagatac cgtcaccggc gttctgttca tcatttgctc tacccgctcg atatccggtc 2886961 ttgactgaat caggcgctct ttcccgataa attcttcaac aaactcattt gccgggtttc 2887021 gaagaatctc atcaggtgtg ccgacttgaa cgatttctcc cgcttttaat atcacaatcc 2887081 tgtcagcaag cttaatcgct tcatccatat cgtgggttac aaacacaatc gttttgttta 2887141 aggttctctg cagttttttg aattcttcct gaagggaatc acgcgtaatc ggatcaagcg 2887201 ctccgaacgg ttcatccatt aaaatgagag ggggttccgc tgccagggcg cgcagcacgc 2887261 cgattctctg ctgctgtccg ccgctgagct catgcggata acggtctaaa tactctgggc 2887321 ccatatccac aagctttaac agctcgcgcg cccgttcttt ccgtttttcc tcaggccatt 2887381 tcagcagctt tggtacgagt gagatgttct gctggatggt catatggggg aacaaaccaa 2887441 tctgctgtat cacatagccg atttttctcc tcagctcaac cgggtcctgt tccataatat 2887501 tttctccgtc gataaagatc cttccagacg atggttctat cagtctgttg atcatcttca 2887561 tcgtcgtcgt ttttccgcag ccgctcgggc cgataaaaca gataaattca ccttttgcaa 2887621 tatctaaatc aatgctgttc acagcttttt tgccgccttt atatactttt gacacttgtt 2887681 ccaatttcag caatccgtgc acctccgcag gtttccttta aattttctga aaagtataat 2887741 ccttattata gtttgaactt tgtaaaataa aaagtttaca atgtgttgaa attatatgtt 2887801 atttatagat tatttattgt tatgaccgag acggaaaggg tgttcttaca attactccgg 2887861 atacctccca cttcctctgc attcagctat tttcaacacc aggaagaaat atgatatatt 2887921 gacaccatca attgccattt gaagggatga tcagctgtga aaaaaaccgc tctcgacatc 2887981 attgaacatg ctgaagagca tctcattgag aagattgccg aaaatatgca tacgtttgga 2888041 atgccttcaa ctgtcggacg tgtgctcgga attatttata tgaatcgaaa accaatgacc 2888101 ttaagcgagc tctctgaggc aacgggcatg agcaaaacac ggatgagcca ggttgtccgg 2888161 gaaatgatcg atgccaatat cgccgaaaag gtgtttgaaa aaggcgtacg aaaagacctt 2888221 tatgacgtcg agcaggatta ttatcaaacc ttcatttctt tatttgcggc gaattggaca 2888281 aaggtcgtga gcaaaaacaa agtgctgtat aaaaaattaa accgggagct gagtgatctt 2888341 ttacaaaggg acgggcttac cccggaagcg gaagagaaag tcaatcagct gctgaatgaa 2888401 ttaaaagaat ggcttcatta ctatgattgg ctgagcaggt tgattgaatt ttttgagagt 2888461 gaggaagtct ttcggtatgt gccgaaaaca aaagaatgca gctctctaaa ataagagagc 2888521 tgctttttgc atcatgaagt taagaccgga aacatgcctt tcagcccggc accaatcatc 2888581 ccgaccgcaa ccacggctaa gattaatccc atcagtctgg taatcacatt catctcggtt 2888641 tttccgagtt tgctgctgat aaaagcagaa tagtggaaaa agagaaaggt cagggcaata 2888701 acggcggcta tgccgatcat gacagccgca taatgaccaa tgccgctatg tccggcggaa 2888761 aggctcatca ctgttgcaat cgttccgggc ccagcaatga tcggaatgga taaaggtgtg 2888821 actgatatat ccgctttttc cttgctttcc ttatgttcat catggtgaag agattgcacg 2888881 tgcgattctt tcgcattcaa tagattatag gcaatgccga aaatgaatat gccgcccgcc 2888941 actcggagcg cgtgaatgtt gatatcaaac agtttaaaga taagatgacc gaaaaccaaa 2889001 aaagctgcga gaataaaaaa ggataaaata gctgccttcc gggcaatcgc ttttctttcc 2889061 gctgcagtat agccttctgt cagcgtcaga aatatcggta cgtttccgat cggattcgat 2889121 actgcgaata aagaaatgaa gacgtgaacg ataaatgaga acatcatata cctccttgtt 2889181 gatagtctct gcacaggaaa tagaatgatt ctccaccctt ttacccggag gcgatttccc 2889241 ggtaaacctt tatagcctgt cagaaacgcg ccatgctaca atgaagtgac aaattgaata 2889301 ggaaggacgt atacagatgt tcaaaaaaat tgcggcagat gccttgggct tatctgatat 2889361 cggaaaaatt atcgaacctc aggactatga caaaacagac gcagatgact atgtcatgca 2889421 tgaagataat gagaaaattt atttcttgat taaaacaaaa gcagacgagt attgctttac 2889481 gaacctggcc ctgatccatg tggacggcga acgcgccact tcctcaaaac gaacgttgaa 2889541 acgctatcct tattcgcaat ataaaatctc tgacgttttt cttgaaactg ccggaaaagt 2889601 ggatttggat gttgaaatta agttcaagct gggcggtgaa caattcgaca ttgatgtcca 2889661 caaagaccag attgaaaagt taaaagacct ttataaagca ctgcttcgca tcgctgaaac 2889721 aacctatgaa aatgacattt taatcaatca agcggagcaa agcttagata aagcagtgac 2889781 gattcttcac catacccgcc ctgagcacgt caatattgaa acgcaataca aagagctgac 2889841 cgaattcgga ttcacttggc tgacatccgt tcgctcgcag tatcatatta aggattttgg 2889901 ggatgtattt gagaaatata ttaataacta gataaaaaaa gacacagctg ctatcgtgct 2889961 cgtgtctttt tttgtatgaa tattgattac tttacaactt ttttctttta taataaaact 2890021 attagtctat tttccctata ttacagataa aggagttatt ttatgtattg tcctcaatgc 2890081 ggccatcaaa cagatggcgg aaatttttgt gagaaatgcg gatcaccgct ccccggtcaa 2890141 tcaggccacc agcatgcagc tcaaactgga gccgctgcaa agcaagcagc aaaacagttc 2890201 ggttcatttg tcttatccgt cctgaaacgc ccttatcagg aatgtaaagc aacaggcgga 2890261 gaacagctga tcagcgcaat cattacgatg gttcttttca gtttgctgac ccctttgatg 2890321 ttttatattc ttttttcaga cggtcccgga agcgtaagct ttacagcaat cttcttagag 2890381 ccaaccattt attttatttt atttctattt ggcctgcatg catgcatctt tttcgccctg 2890441 aaaatcgcgg gaaaccaagt gtctttcaag gattcattct caagattcgg agcatttctt 2890501 attcctttta cggctatttt gattcttgcc cttttcttct ttttattaca tacagacatt 2890561 tgctttacca tattagccgt tggtttaatc ggtgcattct tcgccattcc tcctgcgatg 2890621 ctgagcagtt accagcattc atataaaggg aaggttgatt tcatttactc aacgattgtg 2890681 atttatctga tcatctgcgt tacatttcag cttattatcg aacactatgt caaagaaatt 2890741 ttccgttata tgctctttta aaaacaaccc catcacctgc tggtgatggg gttgttttat 2890801 tgaatagacg ttaagtaaat tcttccgttc ttcactacgc cggtgtaggt ccagttatat 2890861 gttctgagct ttggactgcc gcctgatttt gtgatataga attcttcata cgtcttaatc 2890921 gtgatagccg acccattttg gctccagctt ttcacttcat agttattaaa gtcttctgtt 2890981 gtcccctctt tatttaattt cgacacgaga tgctgctggt cggaataaag ggaactgcct 2891041 ttttcaaggc tgtcttccat cagtgagaaa ttattttgat tcacggcatc tgcctgactt 2891101 tgcagataac tgcccataaa taatgtcact tgttcatctg taacatcgcc gcttgcagag 2891161 ctttcactgc ctttgttttt cgagccagcc caggcggaag tgtatgtctc tggtttatca 2891221 tttttgattt tctttatatt tgtgcctgca gattcgaatg ttgattctgc atcttcgaaa 2891281 atccactttt tctgtttttt atcatatgaa agaagatatt cataactcgg actgtcgtca 2891341 gtcatttcag actttgtata gtcgttatac gaagaagact ggtgaagttc ttttcctgtt 2891401 accgatacct gccacgttcc gtcgtttttc tgagagaggg caaatgtgtc caggtcaaaa 2891461 tcagtttcca agtatctatc ttttaagtat gaatccgcgc ttttcataga atcgacggtg 2891521 tccttcgtct ccgccttcca attggcactt gcctctgtca tctgggctgt attcccatca 2891581 gatagagctt tggagtattg ttttgttgtt ttgacaattg tgttcataat ctgttcctgt 2891641 gtatcttgat caggaattaa cgttaactcc atttctttat catcgatcgg aacgccggca 2891701 gtttttgttt ttccccacgg aaattctgcc tcgactgaag ctgtcattga tccatctgtc 2891761 agcagcggac catatgttac ggatttgaac ggatctttat gaattgattt accgttaatc 2891821 agcaaatctc ccttcccgct cttgatgtca ttcgctaagc tgaatgtcac atcgtctgct 2891881 tccaatgaga gatcaacacg aaagctgcta tcgccaatcg cctgaatgtc ttcctttttc 2891941 acaaggtcaa cgacatcgtt tttcagtttg gctgagactg tatattcgcc gggaatgtac 2892001 ggaccaaggg tttgtgcttg atctgctttc tttacagatc cggcttcctc tttattgaca 2892061 tatagatcgg tatttttata attgctgctc acttcaaaat aaacaggtgc tacctttaag 2892121 tcataatggt caaataccag caggcttttc ccgtcttttt ccgcatatac gatatccttc 2892181 tgggctgttt catcacgcag cgatgcaaaa agttcatctt ttttgtctgg atgatccttc 2892241 aaatatgtaa gaaacggttt tacattattt ttagtgagtt taagattgtc atttaccggt 2892301 gtaagcagag tcgcgatttg gtcctgatcc ccatcattta cggcctgttc aaacttgtct 2892361 actaacctat cctttgaagt aaaatacgct ccggttttat atgcggcgaa taatataacg 2892421 cacgccgcgg caatgctgct ccataaaatg atggttttct tagggatcgg ttttcgcgga 2892481 gcctgcctcg tttctgcagt gctagctgtt tcttgatttg cctgtttgct gccccctccg 2892541 atcggggtgc cgcattgttt acaaaacttg gctccttcat tattctggga gccgcaattc 2892601 ttacaaaata acatgacttt cctcctattc tactaatttg ataacattta ctgcttttca 2892661 tattttataa taaaacagaa tgaaattggg aacgaatgaa aaaattaaat gtctatcaga 2892721 ctaaaaaggt ggaatgaata tgcaaaagct caggattgaa ttaggagaag aaacaaatga 2892781 cgaattatat gatctattgc tgctcgccga tccatcgaaa gacattgtag atgaatatct 2892841 tgagagggga gaatgttaca cagcttgggc cggtgatgag cttgcagggg tttatgtatt 2892901 gctaaaaaca aggccgcaaa cagttgaaat tgtaaatatt gcggtaaaag aatctcttca 2892961 gaagaaaggc tttggcaaac agcttgtact tgacgccatc gaaaaagcga agaagctggg 2893021 ggcggacacg attgaaatcg gaacggggaa ttcgagcatt catcagcttt ccctctatca 2893081 aaaatgcgga ttccgcattc aggcgatcga ccacgatttc tttctcagac attatgatga 2893141 ggacattttt gaaaacggga ttcaatgccg cgatatggta aggctttatt tggatctctg 2893201 aaagcataaa aaagccgccg agagaaaatc ccggcggtct ttttattact tgtttaagtt 2893261 gtagaaagag ttgataccgt ggtattgagc agtttcagcc aactgatctt cgatgcgaag 2893321 aagctggttg tatttcgcaa cacggtccgt acgagacgga gcacctgttt tgatttgtcc 2893381 tgcgtttgtt gccacagcga tgtcagcgat tgtgctgtct tcagtttcac cagaacggtg 2893441 agagataaca gctgtgtagc ctgcgcgttt cgccatttcg atcgcatcga atgtttcagt 2893501 caatgtaccg atttggttta ctttgatcag gatagagttg cctacgccgt ttttaatacc 2893561 ttcagaaagt tttttcgtgt ttgtaacgaa gaggtcgtca ccaacaagct gaactttttt 2893621 gccaagacgc tcagtaagaa gcttgtggcc ttcccagtcg ttttcgtcaa gtccgtcttc 2893681 gatcgagatg attgggtatt tagaaacaag ctcttcatac cagtcaacca tttcagcaga 2893741 tgttttcaca acgccttcgc cagacagatg gtatttgccg tcttctttgt tgtagaactc 2893801 agaagatgca gcatccatag caagtttaac ttcttcgcca ggtttgaagc cggctttttc 2893861 gattgcttca acgattgttt gaagcgcttc ttcgttagaa ccaaggtttg gagcgaatcc 2893921 gccttcgtca cctacagcag tgtttaagcc ttttgcgctt aatactgatt tcaggctgtg 2893981 gaagatttga gcgcccatgc gaagtgcttc acggaagtta ggagcaccta caggcatgat 2894041 catgaattct tgaatatcca cgttgttatc agcatgctct ccgccgttta cgatgttcat 2894101 catcggtaca ggaagcgttt ttgagttgaa tcctccaagg tattggtaaa gaggaatctg 2894161 taagaaatca gcagcagcac gcgcacaagc catagatacg ccaaggattg cgttcgcacc 2894221 aagtttgcct ttgttttcag taccgtcaag ctcgattaaa agctgatcga ttgcgttttg 2894281 ttcagttaca tcaaagccaa gaagctctgg agcaatgatt tcgtttacgt tgttaacagc 2894341 tgttaacacg ccttttccaa ggtaacggtc tttgtcgccg tcacgaagct caaccgcttc 2894401 gtattcacct gtagaagctc cgcttggcac taatgcgcgg ccgaaagctc ctgtttctgt 2894461 atatacttca acttcaactg ttgggttgcc gcgggagtct aatacttcgc gtgcataaac 2894521 atcaacaatg tatggcatga gttttgtctc tccttttgat tttcaaatta tttttgaatt 2894581 aaagatgttc ctgtcatttc tttcggtttt tcaacaccaa gaaggtctaa taacgttggt 2894641 gcaaggtcgc ctaggattcc gccttcacgc agcgtaatgc cttctttcgt tacaatcaca 2894701 gggactgggt ttgttgtatg cgcagtgtgc ggttcgcctg attctgtaat cagaatgtca 2894761 gcattaccgt gatcagcggt aatgatagcg tgtccgcctt tagcaaggat cgcgtcaacg 2894821 acttcgccca agcattcgtc cactgcttca attgctttaa ttgttggttc aaccattccg 2894881 gagtggccga ccatatcagg gtttgcgaag ttaagaatga tcgcgtcatg cttgtcagct 2894941 tcaatttctt tgacaagcgc gtctttcact tcatacgcac tcatctcagg cttcaagtca 2895001 tacgttgcaa ctttaggcga gttgatgaga atacgctctt cacccgggaa ttcagcttca 2895061 cggccgccgc tcataaagaa cgtgacgtgc ggatactttt cagtttctgc aattcgaagc 2895121 tgttttaacc cgtgctgaga taatacttct ccgactgtgt tatcaagatt tatcggttta 2895181 aacgctacat agccgtcaac tgtttcactg aagtgagtca ggcagacgaa atacaggttc 2895241 tttggataat tctcgccgcg gtcgaagtca cggaagtctt tgtttgtgaa cgtgttggaa 2895301 atctggatgg cgcggtccgg tctgaaatta tagaaaatca cagaatcgcc gtcttggatt 2895361 ttcgcaacag gctcaccgtt ttcttttgtg atgacagatg gaatcacgaa ttcatcgtag 2895421 ataccatttg catatgaatc atcaacaaca tccagggcgc tgcggtaaga tgggccttcg 2895481 ccgtacgcca ttgcgcggta cgctttttct acacggtccc agcgtttgtc gcggtccata 2895541 gagtagtaac gtccggaaat gctggcgatt tcacctacac cgatttcctt gatttgatcg 2895601 ttcaactggt tgatgtacgt tttcgctgtc tgcggaccta catcacggcc gtcaaggaag 2895661 ccatggatat aaacctttgt cagcccttct tttttcgcaa gctttaacag tgcgaataaa 2895721 tgattgatat ggctgtgcac gcctccgtca gataaaagac cgaacaggtg caaggctttg 2895781 ttgttttctt tcgcgttgct gatcgcgtca aggaatgttt gattgcgttc gaactctcct 2895841 tcacgaatgg caacatttac gcgtgttaag ctttggtaca caatacgtcc cgcaccgata 2895901 tttaagtgac ctacttcgga gttccccatt tgcccttcag gaagacctac agcctcgcct 2895961 gaagcagtca aagtttgatg aggatactgg ttccaatagc ggtcaaaatt cggttttttc 2896021 gctaaagcga ctgcgttccc tactgtttcg ttacgtaatc cgaacccatc aagaatgatg 2896081 agtgcagctg gttttttact catattgacc ttcctccaat aattgaacga atgactgtgg 2896141 ctcaaggctc gcgccgccga ccaaagcacc gtcaatatcg gactctgcca tatattcttt 2896201 aatgtttgca ggctttacgc ttccgccata ttggatgcga agcttgtctg cagcttcttg 2896261 gctgaagctt tcagcgacgg ttttacggat atgcgcacac acgtcattcg catctttcgc 2896321 tgtagaagat ttgcctgttc cgattgccca gattggctca tacgcaataa cagaagcagc 2896381 aacttgttct tcagaaagac cagcaaggcc ttttttcact tggtcagcaa caagatcatt 2896441 tgttttgccg gcttcacgct cttcaagcgt ttcacctaca cagatgatcg gcacaatgcc 2896501 gtgtttgaaa gctgcgtgtg cttttttgtt aactgtttca tcagtttcag cgaacatttc 2896561 acggcgctca gagtggccga tgacgcagta gtcaacgcca aggtctttca gagcaaccgg 2896621 gctgatttcg cctgtgaacg cgccgctttc ttcgaagtgc atgttttgag cgccgacttt 2896681 taggtcagtg cctttcacag cagaagcaag cttttctaag aaaagcgctg gcgcgcaaac 2896741 aacagcttca gctttgtctg ctgctggaat ggaagatttc acttcttcaa cgaagctgac 2896801 agcttcgccg agtgttttgt tcattttcca gttaccggcg ataattggtt ttctcatctg 2896861 ttccacttcc ttatagcagt tttgagatta tttatcgttc agtgcagcta cccctggaag 2896921 ctctttgcct tccataaact caagggatgc gccgccgcct gttgagatgt ggctcatttt 2896981 gtcagcaagg ccgaattttt caaccgctgc cgcagagtct cctccgccga tgacagagta 2897041 tgtatctttc gcctctgcca atgcttccgc aaccgctttt gttccttgag cgaacaagtc 2897101 gatttcgaat acgcccattg gtccgttcca cacgacaagt ttgctgtttt tgatgacgtc 2897161 agcatacgtt tcgcgtgttt tcgtaccaat gtcgattgct tctaaatcac tagggatttc 2897221 agagatcggc acaattttca cgtttgcatc gttagagaaa tcatctgcaa cgagtacatc 2897281 ttcaggcatg tagaagttaa cgcctttttc tttagcgcgg tccataaatg atttcgcaag 2897341 ctcgatttta tcctcttcaa gaagagattt cccgacttca tagccaagcg cttttacgaa 2897401 agtataagca agacctccgc cgatgatcag gttgtctact ttatcaagaa gactttcgat 2897461 tacaccgatt ttgtctttta ctttcgctcc gccgatgatc gctgtgaacg ggcggtcagg 2897521 attggaaacc gcttttccaa gtacatcaag ctctttttcc attaagaaac ctgcaactgc 2897581 tggcagatgc tcggcaattc cagctgtaga tgcgtgagca cggtgggcag caccgaatgc 2897641 gtcatttaca tatacatctg caagctcagc aaatgctttt gcaagctcag gatcattttt 2897701 ctcttcacca ggatagaaac gtacgttttc caatacaaga acgtctccgt ccttcatctc 2897761 agaaatttgt gcttttacag catcgccgta tgcttcatcc gcttttttca cttctttgcc 2897821 aagcagttcg ccgagacgtg cagcgacagg agttaaacga agctcctcaa ccacttcgcc 2897881 tttcgggcgg cctaagtggc tcgcaagaag gacttttgcg ccttggtctg caaggtgttt 2897941 gattgttgga agcgcagcac ggatacgtgt atcgtctgtt acttccccgt ctttcattgg 2898001 aacgttaaag tcaacgcggc agaatacaac tttgcctttt acgtcgatgt ctttgagagt 2898061 ttttttattc atgcctagga gatcctcctt caaaatggtt tgcatacagc acgaaaaacg 2898121 tgaaaccgtc tgttcaagcg ataactccgc tagggcagat cgcagtcttt ttcggcacag 2898181 ggcagttcgt ctaaaagcca gggcagcggc cttaggcgaa agcgccggca aagctgctta 2898241 aaacgcggtc gtttctctat cacagagcgt tttctgaaag ccggtcttca tggaaaaagg 2898301 gaaagggagt ccgtcccctt cccttgtccg ctttcattat agcgcttcta ttcgaaagaa 2898361 ccaagtcagg tcctttttca gctataaatt aaagaccttt ttttgcgatg taagctgcaa 2898421 ggtcaacaac gcggttagag tagccgcttt cgttatcgta ccaagagatt acttttacca 2898481 tgctgccttc cataaccatt gtagaaagag catcgattgt agaagagttt ttgtttccgt 2898541 tgtagtcgcc agaaactaat ggctcttcgc tgtagccaag gattccttta aggtcgcctt 2898601 cagccgcttc tttaagagct gcgtttactt cttcagctgt tacttcttgg ttcagttcag 2898661 caaccaagtc aactagagaa acgtttggag ttggaacacg cattgctcca ccgttcagtt 2898721 tgccttttag ttcaggaaga actagagaaa ctgctttagc agcaccagtt gatgttggga 2898781 tgatgttttc agctgctgca cgcgcacgac ggtagtcttt gtgcggaaga tcaaggattt 2898841 gctgatcgtt tgtgtaagag tgaacagttg tcatcatacc gcgtttgatg ccgaatttat 2898901 cgttaagtac ttttgcaaac ggcgcaaggc agtttgttgt gcaagatgcg ttagagataa 2898961 catcgtggtt agccgcatcg tatttatctt cgttaacacc cataacgatt gtgatatctt 2899021 cttcgttagc aggagcagag atgattactt ttttcgcgcc agcttctaag tgtttcgcag 2899081 cgtctgcgcg ttttgtgaag aaaccagtag attcaactac gatttcaacg ccttgtttgc 2899141 cccagctaag tttagcagga tcgcgttctg cagaaacttc aattgttttg ccgttaacaa 2899201 caaggttgtt accgtcaact gaaacttcag cgtctaattt tccgtgtaca gaatcatatt 2899261 gtaaaaggtg agccagcatg ttagcatctg ttaaatcgtt aaccgctact acctcaactt 2899321 caggattgtt taatgctgcg cggaatacgt tacgtccaat acgaccaaaa ccgttaatac 2899381 cgacttttac tgccatgatt gtttcctcct ttaaataagt gagagatatt tatattgagg 2899441 gattattcat cccttaataa cttctttgcg gctccttcgt ctgtgacgag aaccgtgttg 2899501 cgtggctttt taaagtaagc ctcgatcgct tcggcttttg atgatccgcc cgctaccgca 2899561 ataatatcgg ggatggcgtc tatgtcatcc agctgcattc cgacagaatg cactttgtga 2899621 accacttcgc cgtccgcgtt aaaatagtag ccgaacgctt ccgtcaccgc gtcgttatca 2899681 tctattttct ttaaatcttc taaaggcgtg tttctgcgct gagccatagt tttagcttcg 2899741 ccgattccgt gaaccagcat actcgctgat ttaatggtgt tcagcacctc tttgacagaa 2899801 ggctcttcaa taatagatga ataggcgcct tgtgacagct gtcccggaac aaacaaaagc 2899861 cggtaagtgc ctgaagcctt ctccgccata tgcgcgcata tggtgttcgc ctggtttttc 2899921 acgtcttcgc ctaaaccgcc tcttgcaggc acaaacaaaa gctcgcggtt tttagaatcc 2899981 ggcgtcatca tttcggcgac agcttcaatt gtcgtaccgc cagttacagc gacgatattt 2900041 ttgcctgaaa atcttttttt catacatgcg acagccgctc ttcccatttc ttttttgacc 2900101 catggggatt gatcgctgtc tccggatacg ataatggcat cctttagatt taaacgttct 2900161 tttaatgtct tttccaaaag agtcaaacct aaaacatctt tcatcgtatc ttccaaaaca 2900221 gaaagcagtt catagccctc ttctgtcaat gtcatgccgt ttgtcttaat atcgaccagg 2900281 ttctgttcct ttaaaaactg aacctcgccc ctcagcacac gctcgctgat tccgagactg 2900341 gcagacaggc ttcttcgccc gatgggttct gtcagcctga tatactgcaa gatttcaaac 2900401 ctcttttgca taacgagcag aagatcaggc aataattttt tttgagcttg tattaactgg 2900461 ttcatgactc aaacgttcct tccttttttg ctggacatta tatgtcccgc tatgacaaaa 2900521 aacgtcccgt catagccaaa aaaaatcatt tctgctttct ttaattattt taacagggtg 2900581 gaattgttta ttcaactgtt aagagccaat tcatcgacaa tattcgcaga gttttcatgc 2900641 cgcgtcgttt tatccagcaa tattttatcc tatatatctt tatcttatac agaaagcgcc 2900701 aaatggtgca tcccaatata aacagccctt cccgtagaaa gggctgtttc attaaagcgt 2900761 tttcatttta tccaaagctt ttcaatttcc tcgagcgatt tgttcttcgt ttctggacag 2900821 atcgtaacga caaacaggaa acaaaggatg ttaatcaccg caaagatcca aaatgtatag 2900881 gcgagcccga aagaatcgat catcattggc acaaactgtc cgatcgccca gtttgctccc 2900941 cataaaaaga tggtcgcaat gcccgcggcc cgcgcacgca gatggttcgg gaagatttca 2901001 gaaatcataa tccatgtgat cggtccgacc gagacacaga aagcagcgac aaaacctaat 2901061 ataaggacga tcatcatgat cccgcttgtt aactcaaaat aaaacgacgt cccgattaaa 2901121 atcataaaaa tagccataaa agcagaaccg atggacatca gtttttttcg tccgacttta 2901181 tcaatcagca acaccgcaat aacggtaaaa ataacttcta caaccccgac gatacaagtc 2901241 gtcacaaatc cggcgttttg cccgaatccc atcattttaa agatttccgg cccgtagtaa 2901301 gtaatcgcgt tcatgccgat gacttggtta aacagcgcca gcaggattcc aatgacaagc 2901361 gcctttctga gacccggctt aaacagctgg gagagcgacc ccatttgttc tatttttaaa 2901421 gagttctcaa tgttctttaa ttcttctttt gcaacagttt ctccattaat acgtgtcagg 2901481 atctttaaag cttcatttgt tttgcccgct ttcgccagcc atctcggact ttccgggacg 2901541 acgagcagga caaggaaaaa aatgacggat ggcaccattc cataagcaag catccatctc 2901601 cagccggtgt gcacgcccca ttcgtatgtt ccggaccgct gcacagctag attaataaag 2901661 tatgttgcgg aaatacccag tatcgtaaag agctgatata acgaagataa acttccgcgt 2901721 atagcgggcg gtgccgcttc tgtaatatac gtaacagaga gcgatgagcc catcccgatt 2901781 cccagccccc cgataatcct tgcaatgatt aaggtggaca cgtcttgaga aagcgctgaa 2901841 acgattgctg atatcgcaaa taacaaagcg gctgtcatta aaatttttct ccggccgaat 2901901 ctgtcactta aaaatccgga tatcccgacg cccacaactc ctccaatcat aatgcttgaa 2901961 atgacaagtc cctccataaa cggactcagg ctgtataaat ctttcagaaa accgatggcg 2902021 ccagaaatca ctgccgtgtc atagccatac aataagccgc caagccccgc cgcacatgag 2902081 atcaaaatga caaatcccat tgaatggctt cttgttacag gaacatttgg ttctaattga 2902141 gttggagtat tcttcatttc cctgccctcc cgaatgttga gtaaagcgtt ttcatttaaa 2902201 ccttcaattg tacgtactta tattaaaatt taacgaaaat tacatttaat tagtacgtac 2902261 aaatatagaa taatcttgtt tgcattttct gtcaatgttt tcttacaaag aacgctgtga 2902321 tatactgaaa tttgtccgta tacattttgg aggaatggat atgttaccaa aatacgcgca 2902381 agtaaaagaa gaaatcagtt cttggattaa tcaaggcaaa atactgcccg atcaaaaaat 2902441 ccctaccgaa aacgaattaa tgcagcaatt cggcgtcagc cggcatacca tccgcaaagc 2902501 gatcggagac ctcgtatcac aaggtctgct gtacagcgtg caaggcggag gcacctttgt 2902561 cgcttcacgc tctgctaagt cagcgctgca ttccaataaa acgatcggtg ttttgacaac 2902621 ttacatatca gactatattt tcccgagcat catcagagga atcgagtcct atttaagcga 2902681 gcaggggtat tctatgcttt tgacaagcac aaacaacaac ccggacaatg aaagaagagg 2902741 cttagaaaac ctgctgtccc agcatattga cggactcatc gtagaaccga caaaaagcgc 2902801 ccttcaaacc ccaaacatcg gctattatct gaacttggag aaaaacggca ttccttttgc 2902861 gatgattaac gcgtcatatg ccgagcttgc cgcgccaagt tttaccttgg atgatgtgaa 2902921 aggcgggatg atggcggcgg agcatttgct ttctctcggc cacacgcata tgatgggtat 2902981 ttttaaagct gatgacacac aaggcgtgaa acggatgaac ggatttatac aggcgcaccg 2903041 ggagcgtgag ttgtttcctt ctccggatat gatcgtgaca tttacaacgg aagaaaaaga 2903101 atcaaaactt ctggagaaag taaaagccac actggagaaa aacagcaagc acatgccgac 2903161 agccattctt tgttataacg atgaaattgc gctgaaggtg attgatatgc tgagggagat 2903221 ggatcttaaa gtgccggagg atatgtctat tgtcgggtac gatgattcac atttcgccca 2903281 aatctcagaa gtgaaactaa cctctgtcaa acatccgaaa tcagtgcttg gaaaagcagc 2903341 cgccaaatat gtcattgact gcttagagca taaaaagccg aagcaagagg atgtcatatt 2903401 tgagcctgag ttgatcattc gccagtccgc acgaaaactg aatgaataaa aaaagcaatg 2903461 tatgggtctc cccgctacat tgcttttttt atagctgtta tctgtttttc caaacgtcag 2903521 cgatgatttc aaacgaacgc attctgtctg cgtgttcaaa ggtttctgag ttaaccataa 2903581 tttcgtcagc ctgtgtcgtt ttgacgaaat cttcaagctt cgccttcact tcttccggac 2903641 ctccgacaat cgtggagctc agctgctcat tgaccatcgc tttttcatac gggctccaga 2903701 tttggtccat atcctcaaca ggcggtttaa gctggttagg cgtaccgcgg acaagatcaa 2903761 gaaacctttg ataatgggaa gtcgcaaggt gctgcgcttt ctcgtttgta tctgccgcga 2903821 taatggtgac accgaccatc gcatacggtt cgtcgagcac gtctgacggc gtgaaggaat 2903881 tgcggtacag ctccaaagcg ggaaccgtat tcgccggtga gaaatgggcc gcgaacgcaa 2903941 acggaagacc aagttcgcca gccagacggg cgctgaagcc gcttgagccc agcagccaaa 2904001 tcggcacatc tatgccctct ccgggaatgg cgcgaacttg attgcgcaca tttcctgacg 2904061 gtttaaaata attgcgcagt tcctctaatt gttctggaaa atcctccccg ctgttgatgt 2904121 ttctgcggag cgctctggct gtcaattggt ctgttcccgg cgcacgtcca agccccagat 2904181 caatccgccc gggatacagt gtttccagtg tgccgaattg ttcagcaatg actaatgaag 2904241 agtggttggg gagcataatg ccgccggaac cgacgcggat tttcttcgtg cctccggcaa 2904301 tatggccaat caaaactgcg gtggcagagc ttgcaacacc ttctatatta tgatgttcag 2904361 caagccagta acggtgatag ccccattcct ctgcccggcg cgccaagtcc atgctgtttc 2904421 ggaatgattc tgcaatcgtt cctccctgaa caaccggaga taaattcaag acagaaagca 2904481 aggtatcttt gcgttggttg ttagacatat tgttctcctt tgcaaatgtg ttatcagtaa 2904541 acagcccaaa gctgtcaggt catgattgaa agaacttcta tcacaccata acacaactgc 2904601 attcaggaat aaaagaattt gattcgatga aattcgaaca atataaaacg aacggtttgg 2904661 aacattattc tgctccaaac aactccttag ccatctcaat aaagagctta gccgccagag 2904721 aagcctcctt tagcgacgga acagcaagct gcacatcacg gtatacctgc gggtccaatt 2904781 ccctggtcac cacatgctct ggcagcggca tccccgacat ggacatttct gataaaatgg 2904841 ccaggcccag gccttctctg atcatactga tcgaggtgtt gatgttatag accgtgaaag 2904901 ctgggtgcag cgtagcaccc gcctgcctga acatatcgat aaatggtgat tcatagccgc 2904961 cgtcacagac gatcatcggt tcatggtcaa gatctttcag cgtaatggct gaatgactgg 2905021 caagcgggtg atcgtccctg agcacgacag ccattttgtc ttttttcaaa tgaatgtact 2905081 ccatctcctc tgttggatac agaagaatcc caacatctat catccgcgta tgaagccact 2905141 ccttgacttc atttacagtt ccctcgtgca gcacgagctc aagtttcgga tatttttgtt 2905201 taaattcact gatcagcttc ggcataaaat aagccgaggc agttgagaat gtgccgatat 2905261 ggatcgttcc cagttcaagc cctttttccg ctgctgctac ctgctcaact ttttcaatgc 2905321 cttttaagac ttctctgatg tgtactaaga tctgttttcc cgtatccgtc agcatcaggc 2905381 cattgcggcg gtcacgaatg atcagcttta catcaagctc agcttcgatc gcagaaatcg 2905441 catggctgac agccggctgt gtcatgttca gcgcctgacc cgcttttgta aagcttcccg 2905501 tttcagctat tttcacaaaa acctttaatt gagtaatggt cataacaatt tacttatgct 2905561 ccttataaaa aagattcatt ttatttatct tatgttctac cgtatcatat gatggaaaag 2905621 ttctacaagg agtgaatgaa caatgaagca gctcccaaaa acgcggacag ctctcctgct 2905681 cgcatttctc gtcatcatgt ggggcgtcaa ttggccgctg tccaaagccg cgctcgccta 2905741 ttctccgcca ttattgttcg cgggcatccg aacgctgatc ggcgggcttt tattagtcat 2905801 agtcgcactg ccgcgtattc ataaattacg cttaaaagaa acgtggccga tttatcttgt 2905861 ttctgctctt ttaaatatta cattattcta cggcctgcaa acgatcgggc tgaattatct 2905921 tccggccggc ctgttttctg caatcgtctt cttccagcct gttctgatgg gtgtattttc 2905981 ttggctgtgg ctcggcgaat ccatgtttgt aatgaaagtg attggcctca tcctcggttt 2906041 tgcgggagta gccgtcatta gtgctgcggg ctttggcggg catatttctg tcattggggt 2906101 tctgctggct ctcggctccg cagtcagctg ggcgctcggg acagtatata tgaaaaaaac 2906161 aggcagccgc gtcgattcca tctggatggt cgctctgcag ctgacgatcg gaagcgtgtt 2906221 tctgcttatc tccggctttt ggacagaaag cttttcggcg atccaatgga cagctccgtt 2906281 tattacgagc ctgctgttca tctccgtatt cgttatcgca ctcggctggc ttgtcttttt 2906341 tacgcttgtc ggttcaggag aagcaagcaa ggtcgcatct tatacttttt tgattccgct 2906401 catatcaatc gtggccagct ccattttcct gcatgaaccg ctcaccctta gcctcttggc 2906461 agggctgctg ctgattgtca cgagcatctg tctcgtgaat acaaaatcaa aagcgcagaa 2906521 agctgcggcg attggtataa acgagaaagc tgcacaataa taaaaaccct cttgccggat 2906581 gcggcaagag ggtttcttat ttactgatgc ttgcgtcctt tgaccaaata tgcaactgta 2906641 atcaaaaggt agatcgccgc agtaatgccg gtaatgacaa ttgatgttgt catgatgacc 2906701 ccgatcagaa tggcgagtaa tgccacaatc gcaaaccatg tcgtgtacgg gaaccatttt 2906761 acataatagg ccggtgtttc cgtttgctgt tttctcgatt ttaaatgagc gaatccgatg 2906821 atcagccaaa tgaataaaac ggtatatccc aatgatccca ttaaataatt aaatgtttgg 2906881 cttcctgcga acagagaaat caatacgcca atatagagag aagaagtgca catcagaatc 2906941 gcaaacatcg gtacgttttt cgatgaaagc ttcgagaaga cctttggaag ccttccgtca 2907001 cttgcctgtg tatacaaaat gcgtgatgat ccgtataaac ctgaattcat agaagaaatg 2907061 atcgccagca ggatgactgc attcatgata tgatccgcgc ccggaatgcc taccatttta 2907121 aagaccatca cgaaaggact ttccggaacg gaattgactt ggttccatgg aatcaggctg 2907181 acgatgatga aaaacggcag caggtaaaac gcgacaatcc gtgtcagtgt gctgcggaca 2907241 gctttcggga caaccttttc cggatttttt gtctctgcaa gcgttacacc gataatttct 2907301 gtaccgccgt aagagtagat gacgacaagc atcgccgtga tcagccctgt gccgccgtgc 2907361 gggaaaaatc cgccgtggtc tgtcaggttg gaaaatccgg atgctgtatg atcaccgaat 2907421 gatacaaata agagcagcaa tcccagaata ataaagataa taataacggt aatcttgatc 2907481 attgccagcc aatattcagt ttcggcgaag attttaacag aaagcaagtt tacaatcgtg 2907541 acgataagag aaattcctaa tgccaacacc cagatcgggc agcccggcag ccaatattga 2907601 atgaaaatcg cagctacaac agcttcagcc gcaatgttaa gcacccacat tttccagtag 2907661 atccagtcca aaaagtaagc agcgtaattt cccaatacct gctggacaag atcacggaag 2907721 gttctggcgt tacggtttcg aacagccatt tccgccagcc cctgcataat aaacagcaaa 2907781 ataatcccgc cgagcaggta tgcgataatg acagatggcc ctgccacatc gatcgctgag 2907841 ctgctcccct taaataaacc tgcgccgatt gctccgccca gcgccatcat cataatatgg 2907901 cgggacgtca tcgtgcgttt taacgtttga ttgtcgtttt tcatcctctt ctacctctcc 2907961 ttctcgtttt caaaaacaaa aaagcccgcc gtctcctacc taatctaata gataaagaga 2908021 cgacgagcct tcggctgacc gcggtaccac tcttgttgat tcttcatgaa gaatcctgct 2908081 tttgacctgt aacgaaggtt agccgttaaa acatagggaa tattcaatct attccgttcc 2908141 gtcttaccac tcccgggcga gttcaaagaa gaatcaggct gcgtcgcacc accccgcagc 2908201 tctctgttct gatcactttc ttttactgct cccaatctat gtgttttagt tttctgaaaa 2908261 actcaaattt tatgatctga atatattaac ataatatacg tgcttctctt ttaactgtca 2908321 ataacttcag agaaaaaaga aactgttatt ttgtcccttt tcgaatggct ttccaaaagg 2908381 attctgactc gtttcctaat gcgtaaactg aaacacctgc tattttatat tgctttgcca 2908441 gatggctttt cgtttgaacg gttttttcgt tttcatacca cacgacatgt ttatgcttct 2908501 ttttgtcaac ataagaaaac gtcatcgagc ctgatttttt gttgaatgcc ggctttgctt 2908561 tttgtttttt gatgagggat ttgagctcat tccattccct tattgtgctg gtacttccgt 2908621 cttttacatc ccagtcatag ccgtacgcag ggattcccat gatgacttta ttggctttga 2908681 tctttttgac tgaaaactgc agagagcttt tgatccagtt tgtgcttgcc actgaccccg 2908741 gctcacccca aatgccgtgt tcatcgtagg tcatgacttg tacgaagtcg gcatatttgc 2908801 cgattttcgc ataatcatac ggccagctcc agtcatcatt tttatcatcg gcgcttttgg 2908861 ccggaacgga taccattgtt ttaatatgtt tcttattcaa agcctgtgag acatattgaa 2908921 tgaagttcga gtatgcagcg cggtcttctg gatttactgc ttcaaaatcg atattgattc 2908981 cgtaatatga gtgctttttg gccagtgtaa ttaactgatc tgtgaatcgt tttttcgctg 2909041 ttttattgct catgacccga ctcgctaaat ctccgtcaaa atcataaatg gcatcattat 2909101 agtttgaaat gacagcccat gtcttgattt ttttcttttt cgcatatgtc agctgcttag 2909161 ttggggcatc gccaatgatt tgtccgtttt tttcaaacgc aaatgtatcg gttgcgatgg 2909221 cattcatgta tgtatgatat ttcgtaagag aattgtatga agccgtatcc ccagtcgtgt 2909281 agcctactgt cataccggct gccttcgctt ctccttttgt atacataaac agaacaatcg 2909341 caatcgccag tgaaaccgct atgatcagcc attttttcat cgcatttcct cctgtatcaa 2909401 gtcatactct tctcatcggc caaaaaattg gaagttgaag ttttttcaag caaaaagccc 2909461 ggcatatgcc tgccgggctt cctgagttca gcggtcagag acgagaatat atgctgcctt 2909521 tactggtcca tgcaccccca caactaaatc catttcaatg tcggctgagt tactcggtcc 2909581 ggtaatgtag ttgatacatg aaggaacagt gacaccgttc gcaatgtttt ggcggatgat 2909641 atcactggct tgtgtcattc tcggtacaat gcttgatttc ggcacgatcg caatataagt 2909701 cgttggcaaa aggctgacag agcggccgat gtcttttgag gagaagagga caaccgtccc 2909761 cgactcagcc aatgtaattt cgctgaatgt aatccctaca ttggcttgct ccgctttttt 2909821 aatattttcc tcgcctttgt cagcatccca ctcccagacc ggcgttcctt cactcggcca 2909881 gtccttggtg agcaggcttt tcagtccgta ttcttcaaag cgggggtcct tcggaatgat 2909941 gacagggcct ccagaaaagc ggctgacttg ctcgcgcagg gcatcgtaaa ggccggttga 2910001 atccgtttca atcagctctg tatggatttt gacacaatgg tttttgagca ctgtgactaa 2910061 gtcatccgct gaataacctt caagtgtttt atattgcggc tgatgcgccc attcagggac 2910121 tgccacgcct cctgttcttc gttcacggcc caggctggat gcgattcggt ttaaaaagct 2910181 ctcttgattc tgaatggttc ccttcgtcat cactgctcct ccttcgtgcg ttcacttgtt 2910241 tctctgtccg caaaccagtc tctgaatctc gatttatgcg gtgccgggaa gtcgcgaatc 2910301 tgggtccaat ttttaagcgg gccgggccct ttcgaaattt tttcgtcctc tgtaaaaggc 2910361 gtcatggcgg ccggcgccca ttttgagccc attttgtaaa gcgataagga ggatgcgcca 2910421 agtccgaatg ctttcattgc aagcttttca ctgatcggcg ccctgccttc tttttcgacg 2910481 atattctgac gatgcttgag tagcagctca tgaagcggga ttttgaccgg gcaggcttct 2910541 gaacaagcag cgcacagtga agatgcgtac ggcagctcct tataatcgtc ataaccgccg 2910601 agcaacggtg ataaaacagc tccgatcggc cccgagtaga ttgagccgta tgaatgtccg 2910661 ccgacatggc ggtacacagg acagacattg atacaggcgg cacagcggat acattgcagc 2910721 acagactgga attccgttcc aaggatattg gatcgtccat tatcaacgat gacaagatgg 2910781 aattcttccg gaccgtccac ttcaccttcc agcttcggac ccgtcaaagc tgtaatatag 2910841 cttgtcagcc gctgtccgac agcacttcta gtcagcatgc tgactagcac ttcaaattca 2910901 gaaaatgacg ggacaatccg ctccattccc atgacggtaa tttgtgtttt cggcaaggtg 2910961 ctcacaagcc gtccatttcc ttcattggtc acaaggctga cggaacccgt gtcagcgatg 2911021 gcgaagttac agccggtaat gccgatatcc gcttccagaa actttttccg gagaatggcg 2911081 cgcgcatgca tcaccagctc ttccggtttt tctgtatgtt gatagtccag tctttcttta 2911141 aacacatcgc gtatctgctc tttattttta tgaagagcgg gcgctacgat atgtgacggc 2911201 ggatcgtgat catcaatctg caaaatatac tcgccgagat cggtttctac gacttcacag 2911261 ccttccttct ccagcacctc attcagattg atttcctctg tgaccattga tttagatttc 2911321 acaattttct tcccgttctt cttttgaatg acatcccgaa tataggaaga cgcctcttcc 2911381 gctgttttcg cgaaatagac atgtccgcct cttttcgcca cattttcggc aagctgtccg 2911441 agatagaaat caaggttttc aaggacatgc tgcctgattt cctctgataa tgagcgccac 2911501 tcctcccagt ttcccagttc ttctgctgcc tctaggcgcc gcgtccgcag acgctcctgt 2911561 gcacctgaaa cagcgcctct cataaattca ttatcaatcc cctgtgatac ccgctcttta 2911621 aaagcgtcag taccgatttt catcgccatg atcctttccc cctctgaatc cagttttatc 2911681 tgctgttgag cacttcggcg atgtgcatca ctttgacatt cttatctttt cggccaagcc 2911741 gtcccccgat attcatcaaa cagccgcagt cagcaccgat cagcacctct gctcccgttt 2911801 cctccacaca ttcgactttt tcatcgacca tctgctcaga aatctgcgcc atcttgactg 2911861 agaacgttcc tccgaatccg cagcagttat gtttgcccgg aagctctgta aactgcaggc 2911921 ccttcacatg gctcaacagc ttcatcggct ccttccgaac acccagcagc ctagtcatat 2911981 ggcacgacgt atgtaaggtc gcttttgtat gaagggtcgc gccgacatcc tctaccccaa 2912041 ggacgttcac aataaaatct gtcagttcat acgttttatc cgccagcttt ttcgctttat 2912101 cggcccattt cggatcatcc tgaaacaggt gcggatactc ccggaacatc gttgtgcagg 2912161 aacccgaagg actgacaaca tattcggaat cctgaaacgt ttcgatcatc cgtttcattg 2912221 cttttttggc gtcatgtaca tagccgctgt tgtaagccgg ctgtccgcag caaatctgcc 2912281 cttctggaaa atcaacctcg cacccaagcc gctccagcag ctcaaccgtt gcttttccga 2912341 catttgtttg aaacatatca acaagacaag tgacaaaaag tgagactttc atgatgaacc 2912401 cctctctcat ccccaatata tgatcaggtc atctgatgac ctgagttaaa ataactatat 2912461 gaatatcgta cactattctg acaatggaag gaaagagttt tctagggata ttttcatttg 2912521 tggcatatca aaaacactcc cgatctccca ggagtgcagt atatggttag atccagccct 2912581 tttcctcagc gatgctggcg gcttctgtcc gatttttcgc attaagcttt tggatgattt 2912641 ctgagatata gtttcgaact gtgccttgag ataaatagag ctccagcgta atgtcttttg 2912701 ttgtcttgcc taaagccgca agcctcagaa tttcttgctc tctaacggtt agcggatttt 2912761 cgtctcgcat catattaaac gtcagctcag ggctgaagac acgttttccc tttacacatt 2912821 ttcgaatggc atcggccaga tcgtcaattt caccgtcttt cagcagatag ccatgtgcac 2912881 cggcctttac ggcgcgttca aaatatccgg ggcgggcaaa ggtggttaaa ataatgacct 2912941 tgctgacgca gccttttttc attaattcct ctgccacatt cagcccgctt cgaaccggca 2913001 tttcaatgtc cataatgcat acatccggct ccagcttcaa aatagcatgt agcgcctctt 2913061 ccccgtttaa tgcttgtccg atgactgtca tatcctcttc taaatcaagc aaagatccca 2913121 aagcgcctaa aagcattcgc tggtcctcag caataaacag acgaatcatt cttttcgtcc 2913181 tccaatcatt ctgctttttt aataagcgga atcgtcagtg ccacaaccgt tccgttatgg 2913241 tctgaaaccg ttaatccccc ttcaatgagc atgagccgtt cttccattcc ccacaggcca 2913301 ttcccaaaca ttttctcctt cggcgctccc tttccgtcat cccgtattac gatcctcatt 2913361 ttgtcagcaa attgagaaat ggtgatggca cagtgggttg ctttgctgtg cttgataatg 2913421 ttagtcacgg cttcccgcat acacatactg ataatatttt gagtgacggg agatatcact 2913481 gaaaagtcgt cggctccttc gtattgaaag gtaatgttcc ccgctcttaa tatgtgctga 2913541 atgtttacga gctcctctgt tatcgtgacc gttctcatat cagaaaccag ctctcgaact 2913601 tgcttgagtg cggagcgtga actggtttcc atttcttttg cctcaagctt ggtccgttct 2913661 ggatcagatg cagccagccg ctgaatgagc tggcttttta atgtaagcag cgacagggtg 2913721 tggccaagag tatcgtgaag atcacgggcg attcgaacac gttcctccct tttagagagt 2913781 tcttttatct gttcgttggc ttgtgcaagc ttagcttcaa gctcaatcct ccgaaacata 2913841 gaacgaattc cgaatggaga aatgagcata atgacgagaa acgggagaac agaaaaaagc 2913901 tcccgaagcg agaccgaatt cgcgataaat tggtataggc atggaaaaag cagtataaag 2913961 attaaagcgc agaacgcacg gttaaaattc gttttctctt tgtaataacc aacaaagttt 2914021 gccggaaaaa aacctaagta tatataggtg atattgtaaa acacactata catcaaaata 2914081 accgccattt gcacgataag ccaatatgta aacgaagctt tgcccacgct gcagaataac 2914141 tggcgatatg ccgctacaaa aaggagcagc ataccatatc cgatcccctg tttgacccct 2914201 gattctttta ataaagagag gaacggcata atcgtataca ccagaaagat ataagggaaa 2914261 aacccgaatt ccttcgggaa aatagatatt gcctttttca tgtattacac cgcttcttgt 2914321 tttcttctta tatatttaga tagtagcatg aagagcatca tataagcgat taatatcaga 2914381 atatttttcc aagtcggact cccaccccgg acaagttccc acgctccgct cccgaaatga 2914441 taagacggaa gccactggcc aatgctctgc atcatgtcag gcatgacctc aaacggcatc 2914501 cacatccctc cgcctaaagc cagcagcata taaagcacat tactgattcc ggccgctgtt 2914561 tctacttttc tcatgaggcc gattagtgtg cctaatgcta aaaaaggcaa tgcgccaaac 2914621 aaaatccaca gtccgctcat catccattca aacggtgaca aggcaatatc attgatgatt 2914681 gcgccgaaca gaaatatgac ggtaattgat aaaacgtgaa tgacactttg gccgatcatc 2914741 tgagctgata aatagatatg atccggaaga ggcgtaaggc ggataaaggc ggcccagcct 2914801 tgtgaccgtt cttgtaccat tcggatgcca agcgtcatga tagaggaacc catcacgctg 2914861 aagactgtca tcgacatcag gtaatgggct tcccatgcac gttgatcagg gacgttggta 2914921 ttcactacat ttgtaaagaa ataataaaag gcaatcggca tgatcagaga ccaaagcaca 2914981 aagtacttgt tcctaagcac ccttttcatt tcagcgatgc tttgcttttg cagcacgttc 2915041 actcacatcg cctccctgtt gccgtcagcc agctggcgaa atgcctcatc gagcgttgct 2915101 tgctcaattc gaatatcccg tgcatgtatg ttttcttgaa agatcagcgc caacactttg 2915161 tctgtatttg atgtctggat gatggttctc tcatgctcgt ggatcactct ctcgacttcc 2915221 gggtgacaag acagcctttc caatgattca cttgaatgaa gcgtaaagga aacagactgt 2915281 ttttgaattc ttgagcggat ttgcattggt gagccgtctg caacaagctg tccttcagta 2915341 aaaaatagga ttcgctgtgc ggcatcatct gcttcctgta aataatgagt tgaaaaaata 2915401 atcgtttttc cttggtccga cagtccgtga atggtctgcc agaatcggtg tcttgatgaa 2915461 gtgtccatgc cgactgtcgg ttcatcaagt ataagcagct ccgggttccc ggcaagagcc 2915521 aaagcaaagc tcaaacggcg tttttgtccg ccggataatt tttctgctct tgttttcaaa 2915581 tcttctttgg tgagtgctgt taacgaaacg agttctttca tggacaatgg attcggataa 2915641 tagctccgga agagttcaag gatttcatcc accttaaggc ccggcatgac acttacttcc 2915701 tgaagcatta cacctatttt ttcacgaacc tgttgatcat cgggaacccg gttaaatagt 2915761 ttgatttctc cctcactcgg tttcagcaat cctaatatca tcgagacgac ggtcgtcttc 2915821 cctgccccat ttggcccgag aatggctgca atttctcctt tttcaatact gaagctgatg 2915881 ttgtttacag cggtttttcg ctggaaatgt tttgtcacgt tgcttactgt tactgcttct 2915941 ttcatcacat gagcacctcc tgatcgttta cattgattgt aaaatgacgg agaagacgat 2916001 gttagtatgg ggtgtcatga tgatggagtg acaaatgtca tttttttctc accccggtgt 2916061 ctaggcaatc ctcctcctgc atcttccaat tcatccatct tttctatctc ccatgtcctc 2916121 tttcttttaa actgctgtga cattcataga aagatacact cttcaaacca tccgagtgtt 2916181 atgatagaaa tattgaactt tatattactt tccggctgaa aggagccaat catgaacgaa 2916241 gcgattttgt ctagaaatca tgtgaaggtg aaaggcagcg gcaaagcatc tatcatgttc 2916301 gcacctggtt ttggatgcga tcaaagcgtg tggaatgccg tggcacctgc ctttgaagaa 2916361 gatcatcggg tgattttatt tgattacgtc ggttcgggac attcagattt gcgcgcatat 2916421 gacctgaatc gttaccagac acttgacggc tatgcccagg atgttcttga tgtttgtgaa 2916481 gctttagatc tgaaggaaac cgtgtttgtg ggtcactccg tcggggcctt gattgggatg 2916541 cttgcatcca tccgccgccc ggagcttttt tcccatctgg tgatggtggg gccttctcct 2916601 tgctatttga atgatccgcc tgagtattac ggaggatttg aagaggagca gctccttggc 2916661 ttgctggaga tgatggagaa aaattatatc ggctgggcga ctgtatttgc ggcaaccgtt 2916721 ctgaatcagc cagatcggcc tgaaattaag gaagagcttg aaagccgttt ttgttctact 2916781 gatcctgtca ttgcccgcca attcgcgaaa gcggcgtttt tttctgatca ccgagaggat 2916841 ctttcgaagg taacggttcc ctctcttatt ctccaatgtg cagatgatat catcgcacct 2916901 gcaacagtag gtaagtatat gcatcagcat ctgccttata gcagtctgaa acaaatggag 2916961 gctcgcggac attgccctca tatgagccat ccagatgaga cgatacagct gatcggcgat 2917021 tatttaaaag cacacgtgtg atataggaac gaaagggata gaggtgaccc tcttagatgg 2917081 acaaacaatt gaatgatgca ccatgcggtt tcctcgcttt gtcagaagag gggtcgatca 2917141 tagctgccaa ccgcaccctt atcaagattc tggattatga accggagcag gttatcggcc 2917201 agcacatgaa tatgatgttg accattcccg cgcagctttt ctgccagctt tatttttttc 2917261 cgcttttgaa attggagcat cacatcgaag aaatatacat ttccctgaaa gcaagagatg 2917321 gagaagaaat tcccgtcctt atcaatgcta ttgcgagaca cgatagcggg gcttctgtct 2917381 ttgattgtgt tctgattcca atgcgaaagc gaaatgaata tgaaaatgag ctgctgatag 2917441 ccagaaatga ggctcaggaa gctttgcttg ccaaacagaa agccaatgcg gagttagaaa 2917501 ttgccttgga aacgctgaaa gcaaaacaag aagaacttct tgagatcaat aaacaaaatc 2917561 aacaatttaa attaaacacc aaaagagagc ttgaactcgc cagaaagatc cagaaaaact 2917621 cgttgactga accgattgta aacgatcagg ttcagattga ctcttattac aacgcatcga 2917681 gtgaattgtc aggtgatctt tacggatatt atcaaatcga tgaacaccgt tacggcatta 2917741 ttatccttga tgtgatgggg cacggaattt catctgcatt gattacgatg tctcttcatc 2917801 ctttgttcca gcgccagatc acgcaaggtc tcagccccgt taaagttatg aaggaattgg 2917861 accggcacct tcacagcttg tttcaaaatg atgaggaagc aagacattat tgcactgcta 2917921 tttatctcga gattgatata gcacggcaaa gaattgatta tgtcaacgca gggcatccgc 2917981 cggcactttg gcaggacgat agcggaactc aacatctgct tcacgcgacc tcgcctccga 2918041 tcgggatgtt tgaagactta gagtttcagt caagcagcct ttcatacacg gaggacggaa 2918101 gattgcttct gtatacggat ggcgtgatgg atcctacggc ttcatgttat ttatttgatt 2918161 tactaaagga tcatcctgat tcgccaatcg ctgacctgaa ggagaaaatc cttacatcac 2918221 tgcagcatca aaaggaagct catcataaga gtgatgacga atgttttata ttagttgatg 2918281 taaaataaaa tgatccatga gacataacaa tgatttgtta catctcatgg atttttttgt 2918341 ttcagcgttt ctttggaata tgtcctgact ccgcatattg aaacacctgc aaggaaggca 2918401 gcgggtgtcc attaaaatca aataaagctt gattatctac agcacttccc ccataccact 2918461 tcccggcgtc ttcagggtcg tattcagcag catagctgga cgcccaccct gacccgtatg 2918521 tttcccataa cactttgttt ttctctatct gtgtcttcgg cccgactgga atccacgccg 2918581 gctcccagta gaaaacacca agtcctgctt tgcccgtatt cgccactgcc tccattacat 2918641 ctcttactgc agttgcctgg ccttgaacag aaattggata tggcaacgtc tgcccgcttt 2918701 ttggtgctgt atttccatgc ccatcgccat cctcagcggt ataggtgtac gatgtctccg 2918761 ccaccatgac ttttttgccg tacgtattgg caacagcctt cagcacggag gtcaaatttt 2918821 gtaatgtgcc atgccagaaa ggataatagg agctagcaaa cacatcataa tccactttgt 2918881 ttttgctgag tgtttctgca ataaatgaat accttccagc cgtttcagga ttggtaaaat 2918941 gcagggcgac caaaatattt gaatttgtct ccctgaccgc tcggcttcct tcattaaata 2919001 attggcacat cttcgtccaa tcagtctcac cggcaaatcc tcctgttgtt tcatttccga 2919061 cctgaaccat gccgatgtca acgccttcct tgatcatctt ttgcaggctt tgtttcgtat 2919121 actcatagag ctttgctttt tttgcttcaa agctgagatt cgcccaggct ttgggcacct 2919181 tttgtttcgc tggatcggcc cagaaatcag agtagtgaaa gtcggccagc accttcattc 2919241 cgttcgctgt cgctcttttt ccgatttcga tggctttttg aacatcattg tttcccccgc 2919301 catacccgtt gccatttgaa tcatacgggt gattccagat gcggacgcga acatagttga 2919361 ccccagcctg ttttaaagtt gtaaagatat cctggcgttt tccgtttgta ttgtaaaagg 2919421 tgacaccgct gttttccaaa gcaataacgc tggatacatc tgcccctttg ataaaatcct 2919481 tgttcatccc ctctactttt ttaacaaaaa gatcctctgc ccgaagctct gacacgtgct 2919541 tctccttctc aatggcagcg gcatatcctg ttgaactaca tgcactccac acgatggcag 2919601 ccgcaaagaa cattttcact ttgcttttca tgatttcatc cccccaagac ttagcaagcg 2919661 ttttcattct atagaaaaaa gaatccgccc atatcgagcg gagcatcagc ctaatgtgtg 2919721 tttacgacaa ttctcacttc atacttttcc atcgtcaggt cgcctgacaa tatgtctcct 2919781 gtcattatgt ccttcacact ctgatcaaac gtgaccagct gtttttcttc cgtgaaattc 2919841 atgacaaaaa tataatcatt gtcctgatcc tgcctcgctt gtacggagac gccttttccg 2919901 tgccgaaccg gaaaaactgg agagagagac aggtctgtga tcagaccctc atagaaatca 2919961 cgctgaaatt gatcctccaa acgcgcgccg ataaaatacg ccttgccctg ctgatactca 2920021 tggcttgtga ccgctggcgt gcgcgcataa aaatcttctt gatacaccgc ttccactgaa 2920081 gctgtcttta catcaatcac ggttgcataa tccttcattt catatatttg gctgcggtag 2920141 ctgacagcgt ttcgatcctt cggatacagg gtgtccgttt caagaggctc aactccaaat 2920201 atagcttgaa gatccggatg ccatccgcct gtgtatgtta agtcatgctc attcacaacc 2920261 ccgctgatat acgtcatgac taaggtgccg ccgtcagccg taaacgcttt taaacgggaa 2920321 acggtgtcct cgctgattaa atacagcatc gggacgatca gcagtttata tggtgaaaag 2920381 tcttgttctt tcgtgatgac gtcgacaggg atatcgtgtt cccagaatgt gcggtaatgc 2920441 tgctgaagcg tttgcggata acgttttgtc gccttcgcaa acccctgagc atcctcgagc 2920501 gcccaatgat tttcccagtc atataaaatc gcggtttgag ccggcctctt cgttccgaca 2920561 acttcggaca gccgttccaa tgtctcgcct accttggcca cttcttgaaa gacgcggttc 2920621 ttcgggctat tgtcatgatc cacaaccgct ccgtgtaatt tttctgatga cccccgtgat 2920681 ttgcggtatt ggaaatagag aacgctgtcc gagccgtggg caatcatttg catggatgac 2920741 agcagattca tgcccgggcg ctttgccttg ttgacgttat gccaattgac cgcgcttggc 2920801 gtacactcca ttaataagaa gggctgctgc ttcaagcttc ggtacagatc attgataaag 2920861 ccgaccttca tcgccaaatc agctgtgctt tcccagtcat tgtgccagac aggataagcg 2920921 tcccagctga tggcatcgac atgctttgca aatttgctgt agtcgaggcc ctgatacggg 2920981 atcaaatccg gtgtgtcagc cataaaattc gttgtgatag ggatatcagg cgtcaattct 2921041 ttcagcggaa tgatttcatt ttcataaaac gaaatcgttt gatcggtgac gaaccggcgc 2921101 caatctaaat tcaggccatg caagccattt tcaccgatcg gcgaagggct ttcaatttgt 2921161 gaccagtcat tgaacgtatg gctccaaaaa ggggtccacc acgcatggtt caatgtcttg 2921221 aggctgttgt catatttcga tttcagccac tcccggaaag catgctggca taaatcacag 2921281 tggcaatctc ccccgtattc gtttgaaatg tgccacatta acagcgccgg gtgatgtccg 2921341 tatcgttctg ctaataagcg gttgatgtgc cgtgtttttt ctcggtagac tttagatgtg 2921401 aggcagtggt tgtgccttcc gccgtgcagc tgtttgacgc gggaggcatt gacgcgcaaa 2921461 acttccggat aggtttgcga cagccaggcc ggacgggctc cgctcggcgt tgctaatatg 2921521 acccggccgc ctatactgtg aatccgctca aaaatatcat ccagccattc aaattgatat 2921581 acgccctcct ccggctcaag tgcgctccat gcaaaaatgc cgacagaaaa cgtattcgta 2921641 tgagaaagct tcatcagttt gatatcgtca gctaaaatat cgggccgatc cagccactga 2921701 tcggggttgt agtctccccc atggagcata aattttgctt ttgttacgtg cgttttttca 2921761 agctttgaca tcacattctc ctccttgttc tcttagccct tcgttccgcc tgcggttaat 2921821 ccggacacaa aattcttttg cagcataata aagatgacgg caaccggtat gctgataagc 2921881 agggctccgg ccgcaaatgt cgtatagctg gcccccatga catcattcac taaattgaat 2921941 agaccgacgg gcaatgtata tgattcaggc gttctcaata tggttgagga cagcacaaaa 2922001 tctccgagcg gaccggtaaa gccgttcatg gccacgactg ccgccatcgg ttttgataat 2922061 ggcagaatga tctggaagaa gattctggtg ctgctggctc cgtcaatctt ggcgctttcg 2922121 tctaaatcca tcggaatgga atccatgtac cctttcatca aatacgtatt catcgggatc 2922181 aggccgccga tataaagcaa gattagcagc cagtggctat tgatcattcc caagatttgc 2922241 gccagcacaa acaaggcaat taaagctgaa aactgaggaa tcatctgcag caataaaaag 2922301 agcgttaaag cgtatttcct ccctttaaac cgaaagcgcg aaaacgcata ggccgtaaac 2922361 gtcacacaga gcaaagaccc tgccattgta aacaggctga tcttcataga gttgacatac 2922421 cactgcacat attgaaggct ttccttgccc gcaaataatt ccttgtaatg atcgaatgtc 2922481 ggatgcttcg gaatgatgga tgtactgatt aagctgttgc cgggattaaa gcttgcgcct 2922541 gccgtccaaa ggagaggata aacaatgatg accgccataa aggctagcaa caagtaagag 2922601 aaaaggagac ggatatatct tctgactttc atatctgcca gcatacctta tgcctcctct 2922661 ttaaaagact ttgtctgtct gaactgccac aatgcgatgg agataacaaa tacagataat 2922721 aaaatggtta aagccgcagc aagtgaatat tggctggact gcattgtcaa tttataaatc 2922781 catgaaacga ggatatctgt cccgccggct gttgatccgg ttacagccgg acctccgcca 2922841 ttgaatagat agataatatt aaagttatta aagttaaacg taaactgagt aatgataatc 2922901 ggagccattg caatgaacac catcggaagc gtgatgtatc tcagctttga aaagacagaa 2922961 gcgccatcaa tcgtagctgc ttcatacaga tcgtccggga tggattgcaa tacgcctgtt 2923021 gagacgagaa agatgtacgg aaatccgagc cagccctgca tgagaatcaa tgcaagcctc 2923081 gaccaattgg catctgtcat ccacggaagc ggatctatcc cgaagaaagc caagatgtcg 2923141 tgattcatcg caccgaagct atcattaaac agtcccgcaa aaattaaaat cgtcacaaaa 2923201 ccgggaacgg cccatggcaa aatcagaatc gtccgaaaaa aacgtttaaa ccgaaggtct 2923261 ttctggttaa caatgatcgc gagaaaaatc cccaaggtga cttgcagtgt ggatgcagca 2923321 agtgtccaaa ccaccgtcca agccagtaca tcaaaaaaag tcgacctcca aatatcaact 2923381 gtgaaaatat ttgcgaacgt ttgaaaaccg acccaatcaa ttaattttgc aggaggagaa 2923441 tgatacaaat catagtttgt aaacgctaat gcaaagctga ataagatagg aaagatcacg 2923501 gcgaaaatta aaataaacaa agatgggccg ctgacgacat aaggatagcc ctcagaaatg 2923561 atatgctggt attgttcctt taaggaactt aatggcttat tttcatcacg ctgttttccg 2923621 ctttggaacg catcgcgaag atttacataa tacaccgcaa ggccaaagca ggtcacgatg 2923681 acagcaataa tcccttccgc cagcagaaaa acggaattat cccgcggcac ttctgttccc 2923741 agtgtaaaga ttccccaaaa ccccatattg agcagatctc caaagaccgc aaaaaacgat 2923801 gcgcctaaga aaagaaagac aatacctttt atccattgct tgttataaaa ttgcccgagt 2923861 cccggaatga tagaaagcaa caaagcgact tgacgatgct gcaccgtttt cacctctctt 2923921 acaatacaaa tctagctttc tctttatttt ccgctgtgct ttgccttaat ttgtcctttg 2923981 gccgtttcag ctgcttgatc caatgcttgt ttcggatctg ccttccctgt tgcaaccgtc 2924041 tgtaatgctg aatcagccgg cgtccatatt tcattcattt ccggaatatt tggtgttggc 2924101 tctgagaaac gggattgttc agtaacagcc cgtgccgcct cgcttttcat aatagccggg 2924161 tcattggcta gggatttcac agcaggaact tctttcgttt cttcatatcg tgttttagaa 2924221 tttttttcat ttgccaggaa aacggctaat tcttgcgcca gctcttcatt ctttgaaaat 2924281 gcactgacgt tgtagctttt gacgccgata aaggagctca tgtttttccc attttccagc 2924341 ttcggcagtt tcgtaatgcc ataattgatt cctgcattcg aaaaggcttc tacattccat 2924401 ggaccagaaa taattgcggc ggcttttcct tctgtgaaca gcgattccaa cacgttaatc 2924461 ccttgttctc caataatgcc agccgggaac aggccatctt tgtaaaactt ctgaatcagc 2924521 gccgcacctt tgacagctcc ttcattattg attccaatgt ctgacgggtt atagctccca 2924581 tctttggcct ttccaaaaat gtatccgcca tatccgctca tcacactttc tgcataataa 2924641 atttgatcga atagggctaa aaagccaaat ttgctgccgt cagcagtctt tttggaatag 2924701 tcgtaccact cttccagcgt tttgggcaat tccttttctg tgatgagatc tttgttgtaa 2924761 aaaagcacag tcgtttcgac cgcttttggc agtccataaa gcttttgatc taccatttga 2924821 gactgaatgg aagcgtcagt ataaagtgat tgaacgtctt ttttgacatg taattccttg 2924881 agtaatcctt ccgtgacagc ggttccgatt tggtcccctg gcattgttaa cacgtcaggg 2924941 cctgtgccgg ccggtccatc cattcgcaaa tcttcaatct gcttggcata cggtttttca 2925001 acgactttga ccttcacatc atgctctttt tcaaatgcag ccacagcgtc tttaatgccg 2925061 ttgctctttt ctttatcctc ccatacaaca agctctgacc cttttgaact cgatttggcg 2925121 ctgctgcttt cctttgggcc gcaagccgcc aaggataaac tgacagctgc gcagagcatg 2925181 aatacggaac acttttttgc cattttcatt gattgtcacc ctttcggtag gaatgaaagc 2925241 gctttaaaga taatatagca tgcctgagaa aatgtgtaaa caaactattt acttcataga 2925301 gtaaattttt ttacctaaat aaaaaatgac ttagtgtcct aagtcatcct taattcatac 2925361 tcttcctgac gattaattct gcgcccacat ataatgtttt taccgttctt ctcttgtcct 2925421 gcacttgttc aagcagtaat tgaacagcgt ttttacataa ttcatgtata tcaatatgaa 2925481 acgtcgtcag aggaggcgag acatacttcg cgaagctgat gttgttgata ctcacaatgc 2925541 ttaccctgtt tggtatggca attccttttt cgttcagggc ttgcagacag cccactgcaa 2925601 tcgggtccgc tgcaatcata aaagcagtcg gaagctgatc gcctaatgtg tcgatcgctg 2925661 ctgacatcag gcggtagccg ttttctacag agaatccgcg atgacagaaa atatagcgct 2925721 cgtccagcat ggctttttcc ctcatatagg atctgaaggt ttgttcacgg atgtccattt 2925781 catcctgatt ggtattcgga tttttgtatg tgccgccgat aaaaccgatg ctcttatgcc 2925841 ccttctcagt caggatgttt accgtcttcc ttgtcatttg tgccaaatcg ggccttaccg 2925901 agtcaaaatg atcgggatca ggagttgaat cgatgaacac gccgttttca gtgagatttc 2925961 tgaggaaagc cagctcttca tctgaaaatg tgccgacggc aataaaccct tccgtatgtt 2926021 caggaatgct ctcgattcca tccgctattt tataagtggt catatcgaca ttgaatgctt 2926081 tcgccagttt ctctacttct aatctcatcg ttttaaaata gacatcttct aattcttctt 2926141 tatctgtcag ccaatataaa aacgcaatat gtttcaccag cggccttact gtttttttgc 2926201 ggtaattgag cttttccgcc gcttcataga ttttctcccg tgtctcatca ggaacagaaa 2926261 ggctttcatc gttatttaaa acgcgggaaa cggttgagat tgaaaatccc gcttcctgcg 2926321 cgatatcttt aattgtcgcc attgtatctg cctccattat tcagctcgca ttgttttagt 2926381 aaaatatttt actttctttt tcacaaatgt caagtgcaca aagccctctg gctgccatgt 2926441 aaaaagactg aaccatttgc ggctcagtct cagttgttcg tatcattcgg aaccggcgga 2926501 attgcccggg aaatgagttg gttattgcac attttcctcg aaatatcccg aaagcacatc 2926561 ttccacattc gtcaaatgcg ccagcatggc ggcttccgcc tgtgcaccgt tcccggcagc 2926621 cacagcattg taaatccgtt cgtgctcctc atacagccgc tgaacggagg tcttcttgga 2926681 aaacagccag attttcctcg tttccctcat tgtttccagc agcaatgatg acacgtgatt 2926741 catcaagtgt ttaagaagtt cattttgaga agcgtccgca agcgcaagat gaaatgcaaa 2926801 gtctgctttc tctcccagct ccccgtccgc ttcaatgctg cccatttcct ttagtgcatc 2926861 ctgaattctt tcgagatctg cttctgtcct tttttcagcc gctagtgaag ccacgccgat 2926921 ttcaagcagt tttctgacct cgagcagctg cttgacgtcc tcttttttca tcagaagggc 2926981 ggctgagagc ggctgagaaa tttgattgag ctcaaattcc ttcagatacg tgccttctcc 2927041 ctgtttcatt tcgacaagcc ccatcgcttt tagcgcagaa agtgcttcgc gaaccgctga 2927101 acggctgact tgaaagctct cagcaagcgc ctgaacagag tccagtttat cccccggctt 2927161 caattcgcca tttttgatca tatctaatag ggcatccgct acttcttcat atattttttt 2927221 gttttaatct gtttatattt caatgcaatt caccccgtaa cttgtaggtc tggctgttta 2927281 cgatctatta tactctgttt tgtgggccgc caaaagattt tgactatttt gtcaaaaagt 2927341 cttgtacttt gatttttttc aaaatataat gctaggtaac tggtcttatt acccagtcat 2927401 cagatgatca tatcatctat agaaaccgct tacatatggc gccagtttat gtttcaagga 2927461 ggggtttggg atgcaatgga cacaggcata tacgcctata gggggaaatt tgctattatc 2927521 agcgcttgcc gcacttgtac cgattatttt ctttttttgg gcactcgcga ttaaacggat 2927581 gaaggggtat acagcaggct tggccacatt ggggatcgcc cttatcattg ctgtattggt 2927641 ttatcgtatg ccggcggaaa aagcgctgat gtccgcgaca caaggagccg tatacggatt 2927701 gttgccgatc ggctggatca ttgtgacgtc tgtttttttg tataaaatca ctgtgaaaac 2927761 gggacagttt gatatcattc gcagctctgt tctctcgatt actgatgacc gacggcttca 2927821 agctctcttg atcgcttttt cattcggggc ttttttagaa ggggcagcag gcttcggagc 2927881 gccggtcgcc atttctgccg cgctgctggt cggtctcggc tttaatcctc tttatgctgc 2927941 ggggatctgt ttgatcgcca atacggcgcc ggttgccttt ggggcaattg ggattccaat 2928001 tacagccgta gaagggccga cagggattcc ggcgatggag atttcgcaaa tggttgggcg 2928061 gcagctgccg tttttatccg tatttattcc tctttattta atcatcatca tgagcgggtt 2928121 caggaaagcc ttggagatct ggccggcgat tctcgtatcc ggtgtttcct ttgctgttgt 2928181 tcaatatctc agttccaatt ttttagggcc tgagctgccc gatgttttgt cagctcttgt 2928241 ttcaatggct gcgcttgctg tgtttttgaa atggtggaag ccgaaaacaa cattccggtt 2928301 tgccggtgaa caagagtcgg ccgcctcaat tgaaacggcg cgcacaaatc cggcggcgcc 2928361 tgcatacaga ggcggacaga tttttaaggc ttggtcgcca tttctgctgc tgacggcgat 2928421 gatttccgta tggggcattc catctgtcaa atccgcgctg accgggcatt atgaaggctc 2928481 tgcggtgttc ttgaagtggc tgaatgctgt tggagaaaaa ctgacttttt cccccggtgt 2928541 gccttttttg aacaatcaga ttgtcaatgc tgacggtacg ccgattgaag cggtttacaa 2928601 gttggaggtg cttggttcgg ccggcaccgc gatattgatt gccgcagtgc tgtcaaaatt 2928661 catcacggcg atttcgtgga aagactgggg aaccgttttt aaagaaacag tccaggaatt 2928721 gaagcttccg attttgacca ttgcttctgt cgttggtttt gcctatgtca ccaactcctc 2928781 gggaatgagc acgacactcg ggatgacact cgcgctgaca ggttcgatgt ttaccttctt 2928841 ttcgcccgtt ctcggctggc tcggcgtctt cattaccggc tcggatactt ctgccaacct 2928901 gctgttcggc aacctgcaga aagtcaccgc attatcagtc ggcatggacc ccgttctgtc 2928961 tgtggccgcc aactcttcag gcggtgtcac aggaaaaatg atttcaccgc agtcgatagc 2929021 ggtggcgtgc gccgcggtag gactcgccgg aaaggagtca gatcttttcc gctttaccat 2929081 taaacacagt ctgtttttgc tgctgctcgt ctgtatcatc acctttttgc agcatcacgt 2929141 attcagctgg atgattcctt aaaaaaatcc tcccgtctag ggaggatttt atttatatcg 2929201 ctttctcgct gccgatgacg gaatattcat ttgatcgcga tattttgcca cggtgcgtct 2929261 cgagatttgg atgccgtgtt gttcatacag caaatcgaca agcttttggt ctgaaagcgg 2929321 ttttgttttg tcctcttgat tgatcaggtt ttccagatgc gttttgactg cataattcga 2929381 cgcatctcca tcacctgaag cctcggcttt tgctgagaaa aagagtttca tctcaaacag 2929441 cccgtaaggc gtttgtattg ttttcccttt aatggcccgg ctcacagttg attcatgaag 2929501 gcttagacag tctgccacct ctctgagagt cagcggcttc attgcgcttc gccctttcag 2929561 aaagaaatcc ttttggcgtg tgatcagttc attgataatt ctcgtgattg tctgttttcg 2929621 ctgccgcagc gcgcggctca gccagcgcca ctcctgatat ttcgcagata aataggagac 2929681 agtatcctga caggagccgg atgataaaag cgttctgtac tgcggatgca gatcgatctc 2929741 gggaaacgag cgggtattca gttccgctgc gatgtgccca ttttttacgg tgataaaaat 2929801 gtcaggctca atatacacat cttgctctgg ccgggcaaac agaaggccag gtctaggatg 2929861 aagagccgcg atatcatctg agatatcttg aatggtatga agcggaattc ccgtctctac 2929921 tgaaagcgtt ttccattttt tttgcgcaaa agcatcaaaa tgagctgaaa ccagcatttc 2929981 cgcttgttca tttctgttcg gcagccgctg taattgaaga aggatgcatt cctgcaaaga 2930041 tctcgcgccg attccagccg gttctaacga ctggagtttt gccaaaacag cctccgcttc 2930101 cttggccgat acagataatc gccgtgctgc ctcctctata tcttcttcca agtacccgtt 2930161 tgaatcaagc gaatgaatca gataattaaa aatctttttt tcagtgtttg tcagattcat 2930221 atcgagtgac tgctgtttta acgcatcctg caatgttttt tgcggattac ttaattgaag 2930281 gcccgcttcc tgtgcattca tcctgttttt gtttgtttta tggtaagata gtggcggtgt 2930341 gtctgtttcc tttcgttcaa taagagggtt ttccagtgag agctcatcaa tgtactcggc 2930401 gagttctgcc gaatgatagc caagcagcgt gatggcctgc ctgagctcct gtgtcagttg 2930461 aggctttaat acttgtactt gctgaagttt catatccatc ttgctcactc ccctttcttc 2930521 attgtacatg attgagatca caccgtatac atttatgaaa aaggagctgc caaagaaatg 2930581 tctgaacttt tttccgtccc ttattttatt gagaatttaa aacagcatat tgaaatgaat 2930641 cagtctgagg ataaaatcca cgcgatgaac agctactacc gttccgtcgt ctcaacacta 2930701 gtgcaggacc agctgacgaa aaacgcagtt gtcctgaaac ggattcagca tttagatgaa 2930761 gcatacaaca aagtcaaacg tggagaatca aaataaacct tccgaattcg ggaagatgat 2930821 gatcggttaa agggctaacg ttcgcatcta taggggaaat ctgtttataa tgggggaaaa 2930881 agggagagaa cacaatgact catcaaatag taacgactca atacggcaaa gtaaaaggca 2930941 caacggaaaa cggcgtacat aagtggaaag gcatccccta tgccaagccg cctgtcggac 2931001 aatggcgttt taaagcacct gagccgcctg aagtgtggga agatgtgctt gatgccacag 2931061 cgtacggctc tatttgcccg cagccgtctg atttgctgtc actttcgtat actgagctgc 2931121 cccgccagtc cgaggattgc ttgtatgtca atgtatttgc gcctgacacc ccaagtaaaa 2931181 atcttcctgt catggtgtgg attcacggag gcgcttttta tctaggagcg ggcagtgagc 2931241 cattgtatga cggatcaaaa cttgcggcac agggagaagt cattgtcgtt acattgaact 2931301 atcggctggg gccgtttggc tttttgcact tgtcttcatt taatgaggcg tattctgata 2931361 accttgggct tttagaccaa gccgccgcgc tgaaatgggt gcgagagaat atttcagcgt 2931421 ttggcggtga tcccgataac gtaacagtat ttggagaatc cgccggcggg atgagcattg 2931481 ccgcgctgct tgctatgcct gcggcaaaag gcctgttcca gaaagcaatc atggaaagcg 2931541 gcgcttctcg aacgatgacg aaagaacaag cggcgagcac ctcggcagcc tttttacagg 2931601 tccttgggat taacgagggc caactggata aattgcatac ggtttctgcg gaagatttgc 2931661 taaaagcggc tgatcagctt cggattgcag aaaaagaaaa tatctttcag ctgttcttcc 2931721 agcccgccct tgatccgaaa acgctgcctg aagaaccaga aaaagcgatc gcagaagggg 2931781 ctgcttccgg tattccgcta ttaattggaa caacccgtga tgaaggatat ttatttttca 2931841 ccccggattc agacgttcat tctcaggaaa cgcttgatgc agcgctcgag tatttactag 2931901 ggaagccgct ggcagagaaa gttgccgatt tgtatccgcg ttctctggaa agccaaattc 2931961 atatgatgac tgatttatta ttttggcgcc ctgccgtcgc ctatgcatcc gcacagtctc 2932021 attacgcccc tgtctggatg tacaggttcg attggcaccc gaagaagccg ccgtacaata 2932081 aagcgtttca cgcattagag cttccttttg tctttggaaa tctggacgga ttggaacgaa 2932141 tggcaaaagc ggagattacg gatgaggtga aacagctttc tcacacgata caatcagcgt 2932201 ggatcacgtt cgccaaaaca ggaaacccaa gcaccgaagc tgtgaattgg cctgcgtatc 2932261 atgaagaaac gagagagacg ctgattttag actcagagat tacgatcgaa aacgatcccg 2932321 aatctgaaaa aaggcagaag ctattccctt caaaaggaga ataaatatgg ggaaaacagg 2932381 atacattggt gctgccattg ttgtggcagc ttgtatcatt attttgtcgg ccgtggtatg 2932441 tttacgggac acagtctatt accagcctat gcgctggact ggcatcatac tgtttttcgc 2932501 gggaattgtg atggttcccg catactcagc aaaaagaaaa cccggaaaag agaagtaatt 2932561 ctcttttccg ggtttttatg tttattataa tcttcccgcg cgaatatcgt ctgtcattcc 2932621 ctcataagga gccttcgaaa tcacttcttc gttgtcgact ccttcatttt tcagaaatgt 2932681 aatttccgca aattcaggta caacgtattt tggatacgtt tcatattttt cgcgggattc 2932741 tttcatcaaa tcaatgtggt cattttggta gcaaaccgta atttcaggat gttcatgcac 2932801 ccatttcggg aagaaaataa tgccatgcat gcgtttttca tttggcataa agtttaatga 2932861 aacatccgtg ccagtcggct ctgtccaaga cactttatat acgccttctg tcagtttgac 2932921 aatattcact tcctgatctc gaacccagcg tccggcaacc attccgctat gaattctata 2932981 atcaattgta tggtcgtttt taatataaat ctcgtattcc catccgtttt catacgtata 2933041 aatcatgtgg cttccgataa agttttccat cttacacact ctccttagtc ttttactgta 2933101 cttcataaat gtctagtaga acgtaatcag gggttctttc tgcggaaccg ataaacaagc 2933161 ggtcatggag ccattgatag acttcactgc ctgtttcaaa cgtcggtacc gtacgaaaat 2933221 aaacatgctc cggttcaata atttccccgg ctgccgcttg ttttcgaaac ggcttgctga 2933281 cttgccgtat tccattgttt tcaatgtaaa tcagttcatg atctgctgtt tcaatcacat 2933341 acctggcaga taaatctgtt ctgccgttag cgcgaatcat ttgtgaatcg gcaccgcccg 2933401 gcaaaatacg tccctttact tccccggtta ttgttcccga acgaatcgga atgaatcatc 2933461 tcagtcccag gcttgtctca ccaatcgtga taggcggatc aaccttgatt tctaaagagg 2933521 cgaatggttt taaaaccggc ttcttcacga gaaccacctc accttcagaa aaaatcatgt 2933581 aactatttac atgttcactt taacaccatt gcagttaact gtcaaacaat aggaacataa 2933641 aaaaacaagg actgtttgaa gacagtcctt gtctgaagct agctttgata agcaagatat 2933701 gtgctgacag tgcttttggc aagacaggca gaggaatcta taatcggaat ctcactttga 2933761 atatgatcta acaccgcatt taaatccgtg caggctgaaa tgatgatgtc tgcatgctga 2933821 ctgatttctt catatagcgt ctgccacaat gcttgtgtat gctgcatatg atttggctgt 2933881 ttgattgcgg cgataagctg gttcacagcc tgctgccaat ggtccttgtg aataacttct 2933941 tgtccatttc ccttcagaac tttttggtag atggcggatt ggatggttgg ctctgttcct 2934001 aaaaccaccg ctttttttgc gggatgcgga atctctttta tcgtttcctc aacaatatgc 2934061 aacataggaa ctgacaatgc ctgctgaatc tcttcatagt agacatgcgc cgtattacaa 2934121 ggcagcgcaa tgaaatccac gcctgttttc tcgagcttta ccgctccgtc gataatcgct 2934181 tttttcatct cgtcatggtc aattggacga tctgcataga agggcgtcgg gcatgaatag 2934241 atcatcatgt gcggatagtc aatatcgttt gaagccccat acagcttctg acagtaatca 2934301 atcaccttat caataaacgg cgaggtcgat ttcggcccca ttccggctaa tattccgatc 2934361 atcaaattca ttcctttcta cttcgtacgg accgcttctt cctctgagcc atcctcatag 2934421 aggataaagc ttttcgcagc atcctcacct aatgtaaact cgacttcaac agacaatgct 2934481 cgcagaaaga aacgggtttc cgaggaagga aataactcca gtctcagctg tccggcgatc 2934541 tccaaataaa gccgttcatt ctcggttgtc acctgtgcag ccgtcccatc ctgcaacagg 2934601 tagctgccaa catagcggct gtatatcgcc gtatcaattg cttttttctt tttatcagca 2934661 ggacgttccg ggacatcata tggctggcca aatagaatat gttccgccgc cttcagaatc 2934721 gcttgttcat attcagtatc ctcttcctta ttactcaaat agatcagcgt tttacgatga 2934781 tcgatatatc ggatcatcat cgtcgaatag ccgggccatc ctccgctgtg gctgacaatc 2934841 cgcccttttt caggactgtt ttgcagcacc cagccaaagc cataatcaat tgtttctcca 2934901 ttgttgaggc gcactggaga aaacgcagat tccttagaag ccttgctgat gaaatcgtcc 2934961 tgatataaag cctgatcaaa tcgaaacaaa tcgcttgtga cagagttaac cgtcccatct 2935021 ccctgtatgc catcgagata cacaacatag ttcgtttcct ccagctcatc agggaggacg 2935081 tatgtttcgg aatgtacatc atacacatat ccatatgcat aatgatcaat tcgctcaggc 2935141 gaaagcctcc tgttatacac tcttgtttca ttcatgcctg ccggtaaaaa aatacttgtt 2935201 tttataaaat ccgcatagct catgccagat gctttttcaa tgataaccgc cagcagcaca 2935261 taccccgtat tgctgtacat ccagccttca ttcggttcaa aataaccaga tagcccctca 2935321 ttcatcagca tatcgacaat atcctgattc accgcaatct tgtgtgaatc ccaattggca 2935381 aaaaaccatc ccatataatc aggaagccct gacgtatggt tcaataaatg ccgaatcgtt 2935441 acgccctgat acggaaaacc gggcagccag cgatccactt tatcctcata gccaagaatc 2935501 cccttctcct ccagcaagat gattcccaat gctgtaaaag gctttgacaa agacgctaac 2935561 tcaaacaaag agttggtttt caacgggcgt ttttccgtca tttccgcata gccaaaagag 2935621 tggtgatata aaatatcgcc accctccgca gccagaaccg tcccgttaaa ctgatgtttt 2935681 tcgcctaatg tctcaaataa cgtctgaaga tgctttcttt tattctgctt cattcctcca 2935741 cctcccatat ctctgtacgt tactaaccta ctaacgtttc aaatattttg aaaaatcctt 2935801 cagttagaga tcctttttaa cccatcacat atacctgccg ttcactatta tttagtgaaa 2935861 tgagatatta tgatattttc tgaattgtga ttaaaaaggc aactttatgc ccatgcaaca 2935921 gaaactataa aaaatacaga gaatgaaaag aaacagatag attttttagt tctttaggcc 2935981 cgtagtctgc aaatcctttt atgattttct atcaaacaaa agaggaaaat agaccagttg 2936041 caatccaaac gagagtctaa tagaatgagg tcgaaaagta aatcgcgcgg gtttgttact 2936101 gataaagcag gcaagaccta aaatgtgtaa agggcaaagt gtatactttg gcgtcacccc 2936161 ttacatattt taggtctttt tttattgtgc gtaactaact tgccatcttc aaacaggagg 2936221 gctggaagaa gcagaccgct aacacagtac ataaaaaagg agacatgaac gatgaacatc 2936281 aaaaagtttg caaaacaagc aacagtatta acctttacta ccgcactgct ggcaggaggc 2936341 gcaactcaag cgtttgcgaa agaaacgaac caaaagccat ataaggaaac atacggcatt 2936401 tcccatatta cacgccatga tatgctgcaa atccctgaac agcaaaaaaa tgaaaaatat 2936461 caagttcctg aattcgattc gtccacaatt aaaaatatct cttctgcaaa aggcctggac 2936521 gtttgggaca gctggccatt acaaaacgct gacggcactg tcgcaaacta tcacggctac 2936581 cacatcgtct ttgcattagc cggagatcct aaaaatgcgg atgacacatc gatttacatg 2936641 ttctatcaaa aagtcggcga aacttctatt gacagctgga aaaacgctgg ccgcgtcttt 2936701 aaagacagcg acaaattcga tgcaaatgat tctatcctaa aagaccaaac acaagaatgg 2936761 tcaggttcag ccacatttac atctgacgga aaaatccgtt tattctacac tgatttctcc 2936821 ggtaaacatt acggcaaaca aacactgaca actgcacaag ttaacgtatc agcatcagac 2936881 agctctttga acatcaacgg tgtagaggat tataaatcaa tctttgacgg tgacggaaaa 2936941 acgtatcaaa atgtacagca gttcatcgat gaaggcaact acagctcagg cgacaaccat 2937001 acgctgagag atcctcacta cgtagaagat aaaggccaca aatacttagt atttgaagca 2937061 aacactggaa ctgaagatgg ctaccaaggc gaagaatctt tatttaacaa agcatactat 2937121 ggcaaaagca catcattctt ccgtcaagaa agtcaaaaac ttctgcaaag cgataaaaaa 2937181 cgcacggctg agttagcaaa cggcgctctc ggtatgattg agctaaacga tgattacaca 2937241 ctgaaaaaag tgatgaaacc gctgattgca tctaacacag taacagatga aattgaacgc 2937301 gcgaacgtct ttaaaatgaa cggcaaatgg tacctgttca ctgactcccg cggatcaaaa 2937361 atgacgattg acggcattac gtctaacgat atttacatgc ttggttatgt ttctaattct 2937421 ttaactggcc catacaagcc gctgaacaaa actggccttg tgttaaaaat ggatcttgat 2937481 cctaacgatg taacctttac ttactcacac ttcgctgtac ctcaagcgaa aggaaacaat 2937541 gtcgtgatta caagctatat gacaaacaga ggattctacg cagacaaaca atcaacgttt 2937601 gcgccaagct tcctgctgaa catcaaaggc aagaaaacat ctgttgtcaa agacagcatc 2937661 cttgaacaag gacaattaac agttaacaaa taaaaacgca aaagaaaatg ccgatatcct 2937721 attggcattt tcttttattt cttatcaaca taaaggtgaa tcccatatga actatataaa 2937781 agcaggcaaa tggctaaccg tattcctaac ctttttagga atattgctgt ttatcgactt 2937841 atttccaaaa gaagaacatg accaaaaaac aaaatcaaaa cagaagccgg actaccgggc 2937901 ggcatatcat tttacgacgc cggataaatg gaaaaatgac cctcaaaaac cgatctattt 2937961 tgatggcaag tatcattatt tctatctata taaccgggat tacccaaaag gcaacggcac 2938021 agaatggcgc catgccgtct cagaggattt ggtgcactgg accgatgaag gcgtggcgat 2938081 tccgaaatat acaaacccgg acggtgatat ttggaccggt tccgtcgtgg tggataaaga 2938141 gaacacagcc ggcttcggga aaaatgcgct tgtcgcgatt gtgacacagc cctcagccaa 2938201 agacaaaaaa caggaacaat atttgtggta cagcacagat aagggaaaat cattcaaatt 2938261 ctacagtggc aaccccgtta tgcctaatcc gggcacagac gatttcagag atccgaaagt 2938321 catatgggat gaccaagata acaaatgggt catggtcatg gctgaaggat caaaaatcgg 2938381 cttttatgaa tccgataatc ttaaggactg gcattacaca agcggattct tcccagaaca 2938441 ggcgggaatg gtggaatgtc ccgacctcta catgatgcgg gcaagcgacg gaacgaataa 2938501 gtgggttctc ggtgccagcg cgaatggcaa accgtggggc aaaccaaata cgtacgccta 2938561 ctggaccgga agcttcgacg gaaaagaatt caaagcggat cagactgaag cccaatggct 2938621 tgactatggc ttcgactggt atggcggtgt gacgttcgaa gacagcaaaa gcacagatcc 2938681 attagaaaag cggtatgcgc ttgcctggat gaacaattgg gattatgcca acaacacccc 2938741 gacaatgaag aacggcttta acggcacaga ttctgtcata cgcgaactcc ggctgaagga 2938801 gcaggatgga acatacagcc tcgtctcaca gccgattgaa gctttggagc agctgactgt 2938861 ttcaactgac gaaatagagg atcaggatgt gaacggatca aaaacattgt cgataacagg 2938921 tgatacgtac cagcttgata cggatctttc ttggtcagag ctaaagaatg caggcgtcag 2938981 gctcagagaa tcagaagacc aaaaacgcca tattgatgtc ggcattttcg ctgaaggcgg 2939041 ctatgcttat gtcaatagag cagccacaaa tcagcctgac aaaagcaata cctatgtcga 2939101 aagcaaagct ccttatgatg taaacaaacg taaggtgcat ttgaaaatac ttgtcgataa 2939161 aacaacgata gaagtatttg ttggcgacgg gaaaaccgtt ttttcaaatg aagtcttccc 2939221 aaagcctgaa gataaaggaa ttacccttta ttctgacggc ggcacagcct ccttcaaaaa 2939281 tataacagtg aaacactttg attcgattca tgaataaaaa caggggcggc gcaggctgcc 2939341 cctgtttttt tattaggagc ggtattctct gttacatatt gggcattgta aggaatataa 2939401 ggctggtttc aaaggaggaa gcgaatgtct aaacaaggaa attttcaaaa atcaatgtcg 2939461 ctgtttgatc tgattttgat tgggatggga gccatctttg gatcagcgtg gctgttcgct 2939521 gtcagtaatg tcgcttcaaa agcagggccc tccggcgctt tttcctggat cctcggagga 2939581 gccattattt tgttaatcgg gcttgtatat gcggagctcg gagccgctct gccccgtacc 2939641 ggaggcatca ttcgataccc cgtttattca catggccacc ttgtcggcta cttaatttcg 2939701 tttgtcacga ttgtcgctta tacaagcttg atttcaattg aagtgacagc tgtgcgccag 2939761 tatgtggcct attggtttcc cggcctgacc attaaagggt ctgattcgcc taccatttcc 2939821 ggctggatct tgcagtttgc cctattatgc ttgtttttcc tgctgaatta ttggagcgtc 2939881 aaaaccttcg ctaaggcgaa tttcatcata tcgattttta aatatattgt gccgattacc 2939941 atcattattg tgctgatctt tcattttcag ccggagaatt tatccgttca aggatttgca 2940001 ccgtttggat ttacaggtat tcaggctgcc atctcgacag gcggcgtcat gtttgcgtat 2940061 ctcggcctgc atccgattgt atctgtagca ggtgaagtcc aaaatccaaa acgcaatatc 2940121 ccgatcgctt taatcatttg catcatcgtt tcaaccatca tttatactgt tttgcaggtc 2940181 acctttattg gtgcaatccc gacagaaaca ctgaaacatg gctggccggc aattggccgg 2940241 gagttctcat tgccgtttaa ggatattgcg gtcatgctcg ggttaggctg gcttgcaacg 2940301 cttgtcattt tagacgccat tctgtctccc ggaggaaacg ggaatatctt tatgaatacg 2940361 acatcccgcc ttgtttacgc ctgggcgcgt aacggcacat tatttggcat attctcaaag 2940421 gtcaataaag atacggggac accccgcgct tcgctttggc tttcgtttgc cctgtccatt 2940481 ttctggacac ttccctttcc ttcgtggaac gcgctcgtca atgtctgttc agtcgcgctc 2940541 attctttcat atgcgattgc acccatttct tcagctgcgc tgagggtcaa cgcgaaggac 2940601 ttaaacaggc cgttttattt aaagggaatg agcattatcg ggccgctttc ctttatattt 2940661 acagcgttta tcgtgtactg gtcaggatgg aaaacagtct cctggctgct cggttcacaa 2940721 ctcgtgatgt ttttgatcta tctctgtttc agcaaatata cgcctaaaga agatgtcagc 2940781 cttgctcagc agctgaaatc agcctggtgg cttatcgggt tttatattat gatgctgatc 2940841 ttttcctaca tcggttcttt cggacatggt ttagggatta tcagcaatcc cgtcgacctc 2940901 attttagtcg cgatcggctc acttgcgatt tattactggg caaagtatac cgggctccca 2940961 aaagccgcca ttgattatga taaataaaga agcaagaggt tttcttgctt ctttattctt 2941021 tacaaacaaa catacacgcg ataaaatgaa tgagagtcag tcattactgg aggtgttcct 2941081 catgccaaaa caaacatcgg gtaaatacga aaaaatattg caggcggcca tagaagtcat 2941141 ttctgaaaaa ggcctcgaca aagcttctat ttctgatatt gtcaaaaagg ccggcactgc 2941201 ccaaggaaca ttctatttgt atttttcatc taaaaatgcc ctcataccgg ccattgcaga 2941261 aaatctcctc acccatacac ttgatcaaat caaaggtagg ctccatgggg acgaggattt 2941321 ttggaccgtt ttagatatat taattgatga gacatttctc attacagaac gccataagga 2941381 tattattgtc ctctgttatt ccgggcttgc gatcgaccac tccatggaaa aatgggagac 2941441 gatctatcag ccttattatt cctggcttga aaaaatcatc aacaaggcca ttgcaaacca 2941501 tgaggtaacg gaaggaatca attcaaaatg gacggccaga acgattatca acttggtcga 2941561 gaatactgcg gaacgattct atatcggatt tgaacaagat gaaaatgttg aagtgtataa 2941621 aaaggaaatt ttcactttct taaaacggag cttaggtact gcttaaaaaa tgactgggta 2941681 acaccgctca ttttttaatg ccctaaaaat gactgacgtt cattcataaa atagagaggt 2941741 gtttcatttg aattgggttc ttgtttttat tgcagggctt ttagaggttg tttgggcctc 2941801 ttccctcaaa catgccgatt cgcttttgga ttggatcatc atttttatct taatcgcggt 2941861 cagctttatc ctgttgatcc gctcttatca aaaaatcccg atggccgcgg cgtacactgt 2941921 gtttgtggga atcggaaccg tcggaacata tctgactgga attgttctgg gcgaatcctt 2941981 ctcagcagcc caaatgttct ttttagcttt attgctggct ggcattttag gaatgaaatt 2942041 atttacgaaa gaaagcaaat ctcagccggg aggtgaaaaa taatggcatg gtttttatta 2942101 gtgattgccg gcatagaaga aattatagct gccattgcca tgaaatatat agacggaaca 2942161 agaaaaaaat ggccgatcat tgtgatgact gttggattcg gcttatcctt ttactgcctg 2942221 tcccaagcga tgatcgtcct gcctgccgga gtcgcatatg ccgtctggac tggcattgga 2942281 agcattggtg tttcggcggt cgggctcatc tggtttaagg agcggtttca gctttcacag 2942341 gtgatttcac tttgccttat cctagccggc gtcatcggcc tgcgtcttac gtcatcttca 2942401 taaaatcaag gcatatacag ctgtatatgc ctttgccatt aagcttcgtg atgtttttga 2942461 agatgaagcg gcggcgggat gagccagcct ttgtttttta gcagccttaa gtattttgcg 2942521 ccggttgccg ctttcgacat atgaaattgc ccaaacatca tggcaatatc ctcacgaatc 2942581 gattgcccca tcattttgct gcatgtcaca agacctgcag cattttctgc tgccgcggaa 2942641 gccgccacat ccggatcgag aaaccgtgca ccaggcggaa tatcgttaag atctgctgtc 2942701 ggcggttcag gagaagccgg cggcagcgcc accccgtttt ctttcaggat cgtgctgacc 2942761 tgtttgattt catcttggca tttctcaata gactcacgaa gcagcttctt caggtcgtca 2942821 tcaccgacat gattcaatag catttggtaa ttgccgacca ttttattgcc cgccatcaca 2942881 taactccaca agccgaatac ctcaccgtaa tgcatcggtt catcctgcgg atttccgctt 2942941 aaaataccca tgctcattct cctcccatat tcaatattgc acatttcata acgtgcccaa 2943001 gcggaggaac atttatgttt cagcggaaaa gatttatgaa atgaaacaaa acaaaaaaga 2943061 caagagtggc aagttgccaa accattgtct ttcctgttgt ttgattggac gcactgaagg 2943121 gattcgcacc ccgacagaca agataccgga aaccattcaa gtgcttttta gtatgagtca 2943181 ttgattctgt ctttaataaa ctttaacgag atggcgggat gctttgcgga aaacgaaata 2943241 cattttcggg gtcatatttc gcctttattt ctcgaagccg cgcaaagttt gcgccataat 2943301 attcttttcc gaagttttca atgttttgat ctggaacatt aacatatgaa cctgctacat 2943361 atggttgcat cagctgacgc actctttcaa ctgatgcaag atttgaatct tcttgtgatt 2943421 tatttttcca actagccgtc cattccgtat aaaataatgg atggcgccaa aaaaaggcag 2943481 tttcgtcttt agggactctg cttatagcac caccccaatt gataaaaaag aaattggctt 2943541 ctgttccagt agcatcttcc aaaaattttc tcatgattga aatgggttcg tcagaccaaa 2943601 aatcatgacc ccatgccgag gagaatttaa cactctgatc atttctgcca gggatgggtt 2943661 cgtcagggtc taagaaatct atagcatctg gatagtataa tgttttgata tctgcttctg 2943721 ttggagttcc cgcatgtaat aaaggtttta ataatcgaat caattcagtt ttcgaaccga 2943781 ggaaaattcc ttctgcatga cacaaaccat ttattttgct gtaaatttca aggtagcatc 2943841 ctaatcgttc atctacaaac ggagcccatt tctgccaagc tttaaatacc gtttctaatt 2943901 gttcccacgg ccagataata ttgaagacgg ttgcagtttt aggggcacga tgaactttga 2943961 atgtatattg ggtattatat ccaaagttac ctcctcctcc gcctctagaa gcccatagca 2944021 aatcctcatt gtgagattga tctgcgtgaa taatccttcc ttttgcatct accgttttca 2944081 gcgcgagaag gttatcactt ataaggccaa tcgatcgtga gagtacacca aatccgccgc 2944141 ccatcgtaat tcccccgatt ccaactgttg ggctatctcc aaacggagcc ataaaaccgt 2944201 ctcgagctaa tccctttaca agcgggccaa cgggaatacc agtttgaacg gttgcaatag 2944261 cgttttcttc atctaagaaa actttattca tgtcactcac atcaataaca attcctccac 2944321 ttactactga aaggttctta tctaaagcat ggcgaccgct tctgacacgt aagggcactt 2944381 tattctcacg agcccattta atggcattac ttacatcgta tgaattttgc gcaaaaacaa 2944441 agacaagagg atagacatcc acataagggt tccaattctt aatagcctct gtatagccgg 2944501 ggtctccttt gaagattaca cgccctgtca actgtgttga tcccatatat tatttcactc 2944561 ccaaagaaat tcgattcaga tactaaaata tgcaggagct ggataatcgc atagacaaat 2944621 gatctacgaa ctataaatat aatacgctaa ggcctttttc gtcggtgagg tctgctgaga 2944681 aacatttttc aaacaatttt gagcaaactt cctgtccaat cctccaacaa gcgttttttc 2944741 ttatcgtttt taggagcagt gtccagtttt tttcggagtg aatattcgtt taggccaaaa 2944801 gaaaagagag atgaagaagt gtttagtacc agaggtatac atccatacaa cagactctag 2944861 atcatcatat actgaatgta tgtagaaagg agacatcagc tttggcaaaa tatcggatta 2944921 tgacctttga cggcggcggt accttaggtg ctttaagttt acaactatta aacagattgg 2944981 ctaggcaaaa cccgaagtta attagtcgaa cccatgtatt ttcgggaaat tcaatcggtt 2945041 catttactgc ccttgcatta gcaagcggaa gatctccgag ggaaacactt cagtattttg 2945101 aggatgaaat cctacccgca ttcagcattt cccggccagg cggacctgtt ttcaaccaac 2945161 aattacccta ttccggtttt attaaagcgg taagaaattt tttcccagca gatcttcaac 2945221 ttatagattt aagaaaacga attgttgtcc catcattcaa attatactct caaaaactgg 2945281 accgttggac tcctgtctta tttcacaatt ttcccggctc tccctattta aatgaaaaag 2945341 tgagtgatgt catactgcgg agcagcggtg ctcccgcgac gcaacgcgcc tatcaaaact 2945401 atgtggacgg atatgtagta gcaacgaatc ccagtacagc cagtatcgcg tttgcagttg 2945461 gtaaagccaa cgtgccattg gatcaaattg cggtattgtc catcggaaca ggtgaagccc 2945521 cgactcggtt aagaagagat acgaggggat ggggaatggt aagtgcagat aacatacgtc 2945581 ccgaaaatct gaagaacctt cctccaaatt ggggagtcct tttggacagg tcgcctaatg 2945641 aacctttact gccatttctt cagatgattg ctggcggtaa tgggtactat gaatccatgg 2945701 tcagtgcgaa tcttctggga gatcgttttt tccggttaga tccgcggatt ccgaacttct 2945761 ccaaaacgga ccctgccgtc gttcccgctg tcattgaaat tgcgaacaaa acaaacttac 2945821 agcctgcgaa tcaatttata gagaagaact gggggagcaa ataattattt attttaaatc 2945881 aattctcgct tatacaattt tgtccgagag aagattctca aaataaatac aggcaatggg 2945941 tagaaccgga tttttttaaa ggtttgttaa tcacaagcta ataagatgaa tgaaaaaatc 2946001 aattcatact tcttcttttg aaagtgaggg ttcaaactaa agaatgtaat tgaaatgtta 2946061 ctctaaggta tgcaattccc tttttcacac aaaaaaagac aagagcggca aatcgccaaa 2946121 cccttgtctt tcctgttgtt ctattggacg cgctcggagg gattcgaacc cccgacagac 2946181 gtggtaccgg aaaccaccgc tctatccaac tgagctacga gcgcatatag actgcgttat 2946241 gagaacgtca gcacaactaa ttatacgata attcctttca aataacaacc ctctatttcg 2946301 agaggccgtt ttttaaatag acaaagcatc ttaattggca atctgacata cgatggtttg 2946361 aacccctgta tttttgggga aaatgggaaa aagagacgac tttgcatatc aggccagctt 2946421 tttgtttgac ctttattgac caaaaatgta tcatgtaact acatacttac ctaaaaggtg 2946481 aaggaggagc attatgaatt taatacctac agtcattgaa caaacgaacc gcggggaaag 2946541 agcgtatgac atttattctc gtctattaaa ggatcgtatc atcatgcttg gatctgcgat 2946601 tgatgacaac gttgcgaact ccatcgtgtc acagctttta ttcttagcag cagaagaccc 2946661 tgaaaaagaa atttctcttt acatcaacag cccgggcggc tctattacag ccggtatggc 2946721 gatctatgat accatgcagt ttattaagcc gaaggtatct acaatttgta tcggtatggc 2946781 tgcgtcaatg ggcgcgttcc tgcttgcagc cggcgaaaaa ggcaaacgct atgcgcttcc 2946841 aaacagtgaa gtcatgattc accagcctct tggcggtgcg caaggtcaag cgacagaaat 2946901 tgaaattgct gcgaaacgca ttctcttgct tcgcgacaaa ttaaacaaag tcctagctga 2946961 acgtactggc cagccgcttg aagtgatcga acgcgacaca gaccgtgata acttcaagtc 2947021 tgctgaagaa gcgcttgaat acggcctgat tgacaaaatt ttgactcaca cagaagacaa 2947081 aaagtaataa cacaacctgc aagagctgcg tctcttgcag gtttttttca tttcaaggaa 2947141 ttgactccct tattctatac tgctcccatt cctcatgtaa cagctcaagc gtcaaatcac 2947201 tcgtctgcct cacaaccaga tcagcaccaa gcatcggctg tccttgaccg acaccaaccg 2947261 caaacatccc cgcagatttg attgcagaaa tgcctgcttc tgcgtcttct attgccgcgc 2947321 aatcagcagg ggaaacatcg agcatcgctg cagctgttaa aaagatgtca ggatcaggct 2947381 tccccttcgc aagagtcgtc ggatcaacaa tggcatgaaa atcatcgata attgccaagc 2947441 gtcttaaaat cttaggagca ttgcgacttg aagatgctaa cccgattttt atattttcgt 2947501 ttttcaattg acatagaagc ctgccaatcc ccggtaaaag atcttccggc gtcaatttgc 2947561 tgatcagcat ttgataatcg cgatttttcc gatgcataag ctcttgtttc tccgcatttg 2947621 tatactttgt ttccgccccg ccaaagatca atatgctttc aagtgactct tctctgctga 2947681 ttccttttag cctttcattc atgtctctgt caaaagggat atcgatttgt tctgcgatgt 2947741 gcttccaagc gagaaaatga tattcagcag tatctgttat cactccgtct aaatcaaaaa 2947801 tgaccgcttt catatactaa tgcccatcac agcttcataa ggtttgaggc taatactctt 2947861 taagtcagcc cgctcctgcg gatagtttga aattagcact ttccaacgct catgaatcag 2947921 ttctggaggc gcttcgaaca gagccttttc ttccgataaa ttcacaacga caagaagctt 2947981 ttcccctcga tattctcgaa ggtaagaaaa gacctgcgga tcattctcct gcaacagctg 2948041 ataatcgcca tatatcataa tcttatattg ctttcgtaat tgaatgagct tctgatagta 2948101 aaagaaaatc gaatcttgat cttccaaaga ctctttcaca ttgatatctt gatagcggga 2948161 atttaccggt atccacgggt ctccggctgt gaatcccgca tgttttccgg catcccactg 2948221 catcggtgtt ctcgcatgat cccttccttt tatcatcacg gctttgacaa actctttttc 2948281 tgacatcgtt ttgttttcga cgactagttc acgatatgca ttctttattt caagatcatc 2948341 atacatctcc agcggcatat cgctgttgac catgccgatt tcttctccct ggtaaataaa 2948401 cggcgttcct ttcatgccgt gcagaaccgt tgcaaatgcc ttcgcacatt ccttacgcag 2948461 tttcctgtca ttgccccagc gggaaataac cctcggctgg tcatggttct caaaataaag 2948521 ggtattccag ccgacattca ttaacccggt ctgccacctt gtcatcgtct tttttaaagc 2948581 aatcaaatca aacggcttga tctgccattt cccatttggc gagttttgtt ctttatcaat 2948641 atccatatgt tcaaatgtaa agatcatatt cagctcttgc ctgcttgcat ctgtgtactt 2948701 tttcgcctct tcaatatcag agccgtttgc ctctccgact gtcatgcagt cgtaatgaga 2948761 aagcacttcc ctgttcatct cttgaataaa ctcatgaaga cgtgggccgt tagagtgata 2948821 acggccgaca atatagctgc ggctgtgatc cgtttcgtag tccggaaaat cggtgtattt 2948881 agaaatagag ccaatcacat ccatccgcca gccgtcaacg cctctatcca tccagaatct 2948941 cattacatca taaacttccc ggcgaacggc ttcgttttcc caatttaaat caggctgttt 2949001 tttcgaaaag tagtgcaaat aatactgccc tgttccttca tcgtatgtcc acgctgagcc 2949061 tgaaaagatc gatccccaat tattcggctc tgagccgtcc ggtttaggat ctttccaaag 2949121 ataataatcc cggtaaggat tgtccttcga cttgcggctt tcagcaaacc aagcatgctc 2949181 atctgatgtg tggttcacga ccaaatccat gacgattttc attccgcgtt tatggacttc 2949241 atcaatcagc tgaaacatat cttcatttgt cccaaacttt tcgtacatgt ttttgtaatc 2949301 gctgatatca tatccgttgt catcctgcgg ggaatcaaat accggggaga gccagatgac 2949361 atccgccccg aggtttttga tgtaatccag cttttgaatc acaccttgca aatctccgaa 2949421 tccatctcca ttggcatcat aaaaactgcg cgggtaaatt tgataaacga cagcttcttt 2949481 ccaccattca ctcattaggc gttctccttt cacatcgtcc ctgtaggaca accggttcct 2949541 cataaacgtt catgtgcagc ggctcgcctt ttacaagctc aaaaataacg cgcttttcgt 2949601 caaccgtcac attgattaat cgatttcgat aattgatgtt gaatgaatat tcgtcccatt 2949661 ctttcggcaa aaacggagca aatgacagcg tctcattcgc ggtgcgcatg cctgcaaagc 2949721 catgaacgat tgccagccag ctacccgtca ttgaagtaat atgcaagcct tcttccgtat 2949781 catgattgta attatcaaga tcaagccttg ctgtgcgctt atataattcg agcgctttct 2949841 tttccagctt gagttcggct gcgagaatcg catggacaga gggcgatagg cttgattcat 2949901 gaacagtcat cggctcataa aattcaaaat ttcgccgttt ttcttccatt gtaaaacggt 2949961 cattaaaaag ataaatgcct tggagaacat ctgcctgctt aataaaattg gagcggagaa 2950021 tcttgtccca tgaccaattc tggtaaagag gccgttccgc tggatctaat tcgtcaactg 2950081 tttgcaggtc tttgtccaag aacgtgtcat gctgaacgaa aatttgcagt tcttcactaa 2950141 atggatagta catgtgctgg atgatttctc tccagacttc caattctact tcctgcacat 2950201 ccagatggcg gcgtttctcc gctgagatac tttcgagact ttgtagagta tactccaacg 2950261 tccaagccgc aatgacattc gtataccaat tgttgttaac gttgttttcg tattcattcg 2950321 gccctgtgac gccatggatc atatacttat tttttcgttt cgagaagtga acacggtcgg 2950381 cccaaaatct gctgactgcc acaagtacgt ctatcccgta ttcttccata tagttacggt 2950441 cgcctgtata attgatataa ttgtagatcg cataacagat cgcgccattg cggtgaattt 2950501 cttcaaaggt gatttcccat tcgttgtggc attcatcacc tgtgaacgtc accatcggat 2950561 aaagtgcccc cttcatcccc aattttgcag cgtttcgttt ggcagcctcc aactgatgat 2950621 agcgatacaa aagcaggttt ttcgtcacct ccggctcggc tgtcgccaaa tacatcggaa 2950681 cggcgtacgc ctcagtatcc caatatgcgg cacctccata tttctcgcca gtaaatcctt 2950741 tcggcccgat attcaaacgg gcatcgcccc cgtaatatgt cgagaataac tgaaagatat 2950801 tgtagcggat tccttgttga agctcctcat ctcctttaat ctcaatgtcc gcttttgccc 2950861 atctttcctt ccatcgatca gtgtgcctcc gttttgcatc ttcatagccg ttctctacca 2950921 catccgccaa aagctccttg gctttcgata aaagctcttc ctcccgaaaa tcacgggaag 2950981 tcgtgacaat cacaaacttt ttcaatgatg ccttcgtttg ataactgtag cgattctcga 2951041 catacatttc agtcgtttta aagctttcat ggacaaaacc ctccgtctcg tttgccattg 2951101 cggctaatac cgtgaagcgc ggtgttccaa atggattttc gatcgttttt gccgctaaat 2951161 ggccgctgtg agaatcagca cctttcgctt cctcctgcca aaactgttct tggtagttag 2951221 aatcttcatt tgccacattt ccatccaggt aaggaacaag cgtaatgaca gcatctcccg 2951281 tcaagcactc cgcttcataa tgaatcgcac agagttcttt tacagcaagg ctaagaaacc 2951341 gctctgacct gattctgacg gttttatctt gaatgcggac aacagcgctt cgccgcagaa 2951401 tcccctcttt catattgagt tctacctcaa ataattcgat tgggttttga tggagatcga 2951461 ttttttcacc gtcaacatat aggcctatgc ccataaagtt catcgcattg atcacttttc 2951521 cgaaatattc tggatacccg tttttccacc agcctactcg cgttttgtcg gggaaccaca 2951581 cgcctgcaat atatgtgcct tggtgactgt cgcctgaata gccttcttca aaattccctc 2951641 tgacccccat atagccattg gcaagagacg tcaggctttc cagcagccgt gtatgctcct 2951701 tattaaatgt atttgttttg attttccatt catcaatctc aaataaccgc tgatttatca 2951761 tcatttcctc ccgaatgtaa gtttccatta tcacggcggg ttttggtcaa atatctaaat 2951821 gcaaaagaga tcatcaaagt aacgccacac gaatggatca tcaatacagt aatcaaatca 2951881 aaatgaacca tgccgatagc agctgccgca aatgccggca gtgctgatgc gcaaatcgct 2951941 atagaggccg cttccttgaa tgatgcaata gagaccatgt ttgatatttt tgtgatccag 2952001 aggccacctg caagaacaaa cgttaacaaa agctggatca tagaaaccac cgtatatgcc 2952061 agcatcatga tcatcggctt atactgtgcc aaccacaatg tatcgatcaa gacctctaca 2952121 tcatggacgt ttggtttctc gagcttaacg tccattttcg catagccaac agaaaacccc 2952181 gtttcgtttt gatcggtgat caccagttga tcaggttgaa atatgatggc gttttcaaat 2952241 ccagttactt tcaatcgccc attttcaccg cttgtctcat attcatgctt catatcgact 2952301 gccatcacat tctgcccatc ttcaatcctc tcagagctct tcccgcctgt tagttttccg 2952361 ttcctgattt gaaaaccctg caattgatca gcaaattgat cattaactcc ttgaatcgct 2952421 gacggcatga aagatgaaac gctgaagcga tccattttca caaacgaaac cgctaacggc 2952481 gccattaagc aggccgttaa aaacagaaag agaaaagaga gctgcagcca gctgaaggta 2952541 ttcccatagc ggcaaacacc tgatggggat gcagccgcct tcaggcagcg gatgataaag 2952601 cttttattct ccagattctt cattggcatt acccctttgt tccgccggct gtcaaaccgg 2952661 acacaaagtt cttttggaga aaaaagaata gaacgcatat cggcagtgcg gctagtatgg 2952721 caccggctgc aaatagagct actttttgct gctgcggatt agaaataaag gattgtaatc 2952781 ctacagcgat ggtcagcctt tccggtgagc gaagcagaaa tttcgtcagc aaatagtcgc 2952841 caaacggtgc cataaacgcc caaagcgctt gtaccgcgag cattggctta acaagcggta 2952901 gaacaattga agcgaaaatc ctcagatgtc ccgctccgtc aattcgcgcg gcttcatcaa 2952961 tttctctcgg cacagtatca aaataacctt tcatcagcca cgtgttcatc ggaattccgc 2953021 cgccgatata gatcgctgtt aaaaaccagt attgatcgag tgcgcctatt agcatcgcca 2953081 agacataaaa agcagtcagc gccgccattg tcggcaccat ttgaatgatt aaaaagaata 2953141 tcaggctctt ttttctgcct gcaaaccgat agcggctgta cgagtacccg gcaagtgtca 2953201 caatcgtaac ctgcaaaacc atgaccgata gcgcgatgac aagtgtattg ctgtaccaat 2953261 tgagataaag cgtttcgtca aatagccgct taaaatgatc caatgtccaa gaacccgaaa 2953321 aatcgagctg aaaagccgcc gaattcccca cacggaaggc tgatgatgcc gtaatcagca 2953381 acggatatat aatgacaata cttaaaagcg tcaaaaataa atacgtacag attttattaa 2953441 gcattctggc agtgctcgcg ttcacctaca taacctcctc attgccaaaa gcattcgatt 2953501 ttttgaaagc aatcagtgaa attccaatga caatgaaaga aattaacagt gtcacagccg 2953561 ccgcaacgga atattggggt gatgtgcctg ttgtcagttt ataaatccac gaaattaaga 2953621 tatcggtcga tccggccccg gctcccgcac tgcctggccc tccctcatta aataaataga 2953681 tgatcgagaa attattgaaa ttaaacgtat actgagtaat catcacgggt gctgtggcaa 2953741 ataaaatcat cgggaatgta atatgccgaa aacgctgaat aaaagtggcc ccgtcaatct 2953801 ttgccgcttc atacaattca cctggaatcg cctgaagcac tcccgttacc atgacatata 2953861 tatatggaaa gccgagccac gtttgaatca taatgagggc tgtctttgtc cagaaaggat 2953921 cggtcttcca cgcgatcgca ggcagctcga caaacggcag gtgattgaat aatggtatca 2953981 cctgtgcatt caccgctcct atgctgtcgt taaacatgtt ggaaaaactc atgattgtaa 2954041 taaacgccgg aacagcccat ggaaataaga aaatcattcg aaatatccgc ttgcctttta 2954101 taaaatcctg attgacgaaa agtgccgtca caatacctaa aatgatttgc agcgttgttg 2954161 cacagattgt ccagataacc gtccagccca gtacattcac aaatgtttca cgataggagc 2954221 caaggaaaaa aatatttaag aaatttttaa acccgaccca gtcaatcaga cgattaggcg 2954281 gaatatgata aaaatcatag tttgttaatg caacaaacag agtcaccaaa accggaaaaa 2954341 taatcacaaa caccatcatg atatatgccg gcagtgtaaa tagatacgga aaacctttat 2954401 cgcccgcatg acagatcata tccttggctg ttgtattgac ttccaaaccc gccgctttca 2954461 tagcggcggt cttacgtgaa tcatgaatat taaagatata gaacatgagg aaaatcattg 2954521 tcacgatcaa ttgcagcgtg ccttcaatca gcataaacag cgagtgatct tcaccgggaa 2954581 cacttcccaa tgtcatcaat ccggttagcg cctgtatacc gaaaacgcat aattcaaaag 2954641 caaacaagcc tgtgatggca agaaataaga gcccctttga caactgctga ttcgcaatct 2954701 gcccaagtcc tggaatgatc gataaaagcc ctgcctttcg tttttgcttt gtaagtgtgt 2954761 gatgtttatt catttttccg ccctctattc ttccggacgc tatcccgccg ttttatttca 2954821 catacttttc tttaatattt tcctttatga cgtttacagc atcattcgct gatgtttgtg 2954881 tcgatttttt tcctgaagct gcatcaaaaa ttaaactttc cgctcctgtc catacttcag 2954941 ccatttccgg aatatttgga gtcggcgttg ctgtttcata ttgtttaatc acagctgacg 2955001 tcagttcatt cttttgctca tcggctttct tccttgcagc cgtgttggcc ggaacttcgt 2955061 ttgtatcctc ataaaaagcg taagcattgg catcatttgc agcatactca agccattttt 2955121 cagccagctc gggctctttt gtatatttcg aggcaaccca gcccttcccg ccagcaaaag 2955181 gggcgtattc ttctccattt ggcaatgtcg gaatgggagc cgctccgtag ttcaatttag 2955241 cctctttata gttggcagct gaccaaggac cgccaatgat cgcagccgct ttgccttcta 2955301 aaaacatctg ctgaataaag tcgtctgcgc ttgaattgtc ttgcattcct ttcggccaat 2955361 atgtctcaaa ccatttctcc gcatatttca ccgcttctac agccccttta ttgttcaggc 2955421 cgatgtcccc ggaatctgtg ccgttttttc caaacacata tccgccgtat ccagccaata 2955481 agccgtacga catataaaag tcagtccatt ttgctaaaaa tccggttgat tttccttttt 2955541 ccgaagcaaa cgcgaatcga ggatcttccg ttaacttttc aaggtcttta aatgtttttg 2955601 gcgctgtttt taaaagatct ttgttgtaat acaaaataag tgtctcaatg actagcggca 2955661 ttccgtacac tttgccgtca actgtcacct gctgcatttc tttatcacca aagctttttg 2955721 tgttagatgg cttaatatca agtaaatgtc cttgttgtcc caaaccgccg atccggtcat 2955781 atgcagcaag cataacatca ggcgcattac ccgccgggcc atcaagagga agcgcttcta 2955841 actgttcgaa catttgcttt tcaacaattt ttactgtgac atcattttct ttttcgaact 2955901 ttgtttttat gctttcaatg tattctttat acgtttcttc gacagacaca gtcagcacct 2955961 ttttgccatc agagcttgct ggattttttg aacttgagca ggcggcaagg ccgattgcca 2956021 ggaatgatgc cgccaatatg gcgaacccct tttttaaaag aaccatctct tttcctcctt 2956081 ctatttacga aactataaca attgtattgt cctatagaaa gcggttacaa caactttcga 2956141 tttgttaccg ataacagaat gttatacagg ggcggcagca ctcaaaatca aaaattctcc 2956201 cggctgaacg gcaatgacat cgtgatgctg tagcggctgc tctgtccatg catcacagat 2956261 tttcttattc ctatcaatat tcaactctcg taaactgacg tgttgaacca cattcccttg 2956321 attaaagaaa taaatcagta ttttttcatc aagagtccgc gaaaagctaa tgaaatcatt 2956381 tttgtcgtcc agcagattcc actcaagatg tccttcagtc aataaagtgt tttcctgctt 2956441 gcgtaaagca attaaccgtt tcataaattg cagcatgtct tggttttgct tctctttttc 2956501 ccaaaccata catttccggc ataatggatc attttcgccg ttcagcccga tttccgttcc 2956561 gtaataaatg catggtgagc ctgtctgggc aaacataaag gccagcaacg cgcgtgcttt 2956621 cttctcatca ttgcggcatc tggtcaaaag gcgctttgta tcatggctat ccagtaaatt 2956681 aaacatcacc tcattggcct gcttcattcc attcatcaaa tgtgcattga cacggtgagc 2956741 catacgtgaa gctgagatcg tctggtcagc aaagtattca atcataggct ctgtaaaagg 2956801 gtaattcatc gccgcatgaa attcatcccc tctaagccag ggttcggcag aatgccagat 2956861 ctcacctaaa atataaacat caggcttttc agtagataca gcctgcctaa atgtcttcca 2956921 aaaaacgtga tccacttcat ttgcgacatc caaacgccag ccgtcaatgt caaattcgcg 2956981 aatccagtac aaagcaatat caagcaaata tttctgcacc tcgggattag ccgtgtttag 2957041 cttcggcata tcagctgtaa aagcaaatct gtcataattg tcgtctgtga cgggaaaaga 2957101 gtgaatatgg aaccagtcct tatagcggga ttgatctccg tttttgacga catcctgcca 2957161 ttgcggagac gcgcttccta tatggttaaa aaccgcatca agcataattc tcatcccccg 2957221 ctgatgcagc tggctgacca atgtacgaaa aagctcagga tccccgaaat gcggatcaat 2957281 agaaaagtaa tccagcgtgt cgtatttatg attagaaggc gcggaaaaga tcggtgtcag 2957341 ataaatgccg ttcaccccta aatcctctaa ataatcaagc ttgtcaacaa ttccttgtaa 2957401 atcccctcca aaaaaatcat tgacgtccgg gtccttgctc ccccacggca atgcattctt 2957461 cggtgacaag tcttctcttc catttgcaaa acgctccgga aaaatttgat accaaaccgt 2957521 tgacttgacc cattcaggcg cttgaaatgt atcagcctcg tgaacaaacg gaaatttaaa 2957581 gtaataatga atcgtttcca gtgttttttc gttataaggg catacacccg aacttccgaa 2957641 aaagatgtct tcatgatcgt ctgttacaac aaacgcatat tgtaaacgcc taaatggcgg 2957701 caccacttca gcaaaccaat agtcatgcat ttctgtagca gcaattttcc tcatcggctg 2957761 ctcgtttgcc gaccatttgc cgtcgttgta ctcataggga tcaccccaaa tgaatcgaat 2957821 gtgatctgca tcaccttttt tcgtccgaat cttgatatgc acagtccgcc catcataaga 2957881 ataagcatct gtgctgaatg gctggtgatg aatcgctgca tattccatca tgtttccccc 2957941 tttgatttcc gttttattga agccggctca tagtttgaaa gtatcatgat gaaattgtgg 2958001 gaacaatcct tttcaccctg ttaccgataa cagaataagg cgcttacagc gttgattctc 2958061 gtacaattaa ctctggttca aaaaatagac ttccttgtgc agcgccgtct tcattcattt 2958121 ttttcagcaa cattttcgca caggcttccc ccatttcaac aacaggctgt ctgaccgtag 2958181 tcaagcgcgg cgaggagatg cgatcaagaa acacaccgtc attcccggta accgcaacgt 2958241 cttctggaat tcgctttcca agggattgcg ccgcacgaat gacgccgagc gcgattcgat 2958301 cagatgcgca gacaaatgcg gcctgattgt ccatggattt cagcagttct cttgcaaggc 2958361 attcactttt cttagaactg ttgtcgatcc gaaacatatt cgatttttta aagcttttat 2958421 tcatcgcccg tatatacccc tgttctcttg cacgttcgaa aggctcatct aaatcaatgc 2958481 caaaaaagac aacttcccgc tcccccagcc ccataacatg gcgggttgcc ataaaagtgc 2958541 ctttctcgtt attcacatcg ataaagtcat agcccatttc attttgtcca aatacgacga 2958601 gcggcttctc aaaagctttt attacacctt caaaatcgtt ctttctcaag ccggtggcaa 2958661 taatgccgtc acattggcca atattaagag aatttcttgt cacaagctgg agagcatagt 2958721 gattgcgatc cagctccctg ctgattcctg tcagcaggtt catgtaatat ggttctgtcg 2958781 tatccatttc ctcaagtatc aatagtttca caacctgtgt tctgttttgc acgagcgctc 2958841 tcgccgcata attagggatg taattcagct ctttcatcgc agaatgaaca agctttttca 2958901 attcatccgt caccgtctca gggtgattga tcactcgtga taccgtcatt ttcgaaacat 2958961 ttgctttttt cgccacatct gacaatgttg ccattttcat cccctcctta tctgtgctta 2959021 ttatccaaac tagtgataaa gtcctctatt actgctaaat atacgatgca ggccaaagag 2959081 aaataaaaaa gagatttccc ttaaggaaac ctcactttgt taaaaacact cgatttttca 2959141 tggattcata cgctaggtgg cagactcatt ctctccactt ccatcagaaa atctcttttt 2959201 taaatttctg tccacttttt ttctaaaatc ggataagaat aattttgcat ttgctcaatt 2959261 aactcatccg gccgtgacga gctgtgaatc agttttaggt gcgattcgtt agaaaaccct 2959321 tcttgaatgc tgtatttcac cattttcatc attggttcaa aatatccgtt tacattgtac 2959381 agtccaattg gcttttggtg gatgccgatc tgtgcccagc acagcacttc aaataattct 2959441 tcatatgtac cgaagccgcc cggcatcgag ataaagccgt ccgccagctc gctcatttta 2959501 gcctttcgtt catgcatccc gtttacttca atcagctcag tcagattctg atggacaacc 2959561 tccccgctga acaaaccgct cggcatgacc ccgattgcag ttccgccgtt ttccataatc 2959621 gcgtcagcaa tcgtgcccat caagcctacg cgggagcccc catagacaag gccgattccc 2959681 tgctcagcca tatacacgcc aagctctgcc gcttttcttt tatacgcttc atttccccca 2959741 gggtttgatc ccgcaaatac acaaatggtt ttcatcttgt catctccgca tctatatatc 2959801 gtgttaaaca ttcaaaaaca cactatatat tgtcccatct tcatgtgata atatcaatat 2959861 gaaatacata aagaatgcag gagtgatgag gttgcagctg gctgatgcag aaaaatggat 2959921 gaaagagttt tacgaaaaaa gaggctggac agaatacgga ccttttattc gcgtcggctt 2959981 tttaatggag gaagccggag aactggcccg ggctgtcagg gcgtatgaaa tcggcagaga 2960041 ccggccggat gagaaagaat cgtcacgcgc tgagcaaaaa caagaattga ttgaagaaat 2960101 gggagatgtc atcggaaata tcgccattct tgctgatatg tatggtgtct ctttagaaga 2960161 cgtcatgaag gcccaccaag aaaaactgac aaaacgattt gagcatgcat aaaaaagcgg 2960221 ccgcgatggc cgcttttttt aacctgtgat ttcatcatgg tgatcaaaga aatgctgctt 2960281 tcctattttg tgaaaaaggc ctgttttatg cagtagctcc ttcggctgcg attgcaatcc 2960341 tacaatcatc agctttccat tgtggcgttt aattcgattc ataatgttcc caagcaccgc 2960401 ttcagctgac gtatccatat agtgcacctt attcatgagc agaataaggg ttttcggttt 2960461 tttctgtaca tgctccagca atgacgattc aagggaatca attgatccga aaaacagcgg 2960521 cccttctatg gcatacatgc tgacagatgg atcttctctc ttcgccagaa caggatgcgt 2960581 ttcctgattg tggatgcggg tcgcttcgct cattcttctg ataaagaaca cgaatgcaag 2960641 cagcaatccg gttgccacac cgatgattaa gtcaaacaga accgtaaggg cgaaggtcgc 2960701 cgccaaaata aaggaatcag catttttcag tctcagcatg tttgcgactt ccttgcgctc 2960761 actcatattc catgcgacca ccatgagaat cggtgccata ctggcgagcg gcacatggga 2960821 cgcataaggc gcaaatacaa gcaggacaag gagaacgact acgccgtgaa cgacgccgga 2960881 aactggggaa accgctccgt tttttatatt ggtcgccgtt ctcgcaatcg ctcctgtagc 2960941 cgggattccg ccaaacaggg gcgctgccat attcgcaatc ccctggccga caagctcctt 2961001 gttgctgtca tgctttgagc ccttcatgtt atcagcgacc attgcggaca aaatcgactc 2961061 aagtcctcca agaagcgcga tgacaagcgc agccggaaac agcataacca ttttatccaa 2961121 agtaagctca ggaaactgaa attccggcaa atggcggggg atttctccat aagttgaccc 2961181 gatcgttgcc atgcggtcag ggaaaaagac aaccgcgacc actgtggaaa taagaagcgc 2961241 caacaaagcg cccggcactt taggcatcac cttggcggat acaagcaaaa tgacgagccc 2961301 gatcacagct gtcaaaatgg catacacgtt aaaggtgccg agctgctgca caatttcaaa 2961361 catgttgtga tgaaagttct catgtttttc aacatttctc aatccgagaa aattagcgat 2961421 ttgttccgta aagatcagca cggcaattcc ggctgtaaaa ccgacgataa cgggtttggg 2961481 cacgaatttc attatttttc cgagcttaaa cagcccaaac agtaccagca tcactcctgc 2961541 cataaacccc gcaatcagca gattttccaa gccgtactgc atgataatgc cgaataaaat 2961601 cgggacaaag gcgcccgtcg gaccgccaat ctgatatttt gatcctccaa acaaagaaat 2961661 acaaatccct gctataacaa cagtgtatag cccatattca ggctcgactc ccgaggcaat 2961721 ggcaaacgcc attcctaaag gaattgccac gacacctact acgatacctg caatcaagtc 2961781 tttctgaaat ttctgcaaat tgtatccctt gaatctccct gagaatcgca tattttgtta 2961841 taacctccct tatgagtgat tgtttataag ctcagtttca taaccgttaa tgaccacatc 2961901 aagttttcct gtttcagggt gaatgacaag cccgtgaacc ggcacttttt tcggaagcag 2961961 cggatggttc ttaatcatgt tcacactgtg ggaaacgctt tcttccacgc tgtgaaaacc 2962021 agtcagccac gttttcaaat cgagtccggc actcgtcagc aaattcaggc agctatcctc 2962081 caccccgcgt tcctttgctt tctcaagaat cgaggacgca ttcagccctg acattccgca 2962141 ttcatgatgg ccgacaatgc atacctcttc agcctgcaat tcataaatcg cgaccagtat 2962201 gcttcgcatc acgcttccaa atgggtgaga aacgatggct cccgcgtttt ttacaatttt 2962261 agcatcaccg tttttaagcc ccattgcttg cggaagaagt tctgtaagcc ttgtatccat 2962321 acaggtgaca atgacgagct ttttcgaagg aaactttgtc gttttgtacg gttcatactt 2962381 cttctcactg acaaaccgct gattgtgttc caaaattgat gttaaagaaa ccatttgatt 2962441 catctcccat ccatatgatt ttgcaagcct tcttacccag cttacagtaa ggaattatag 2962501 cataggaata agccaagaaa aggttttcaa aaaaagacac tataattgga ctgtagaatc 2962561 aaaacataaa catttatatc tttcaaagat aataaaattt atatttaatg catcctataa 2962621 tccggctgca gttcgtatat cgatgatttg tctgacaaaa aatatgggtg aattctgata 2962681 attaaaaaac ttttttaagc agatttagct gttcgatctt cattttaagt tcaaaagaac 2962741 cagaaattaa aaaaacgcag ctatattttt aacatctatt tattttcgat ataatgaatt 2962801 agacaacagc cataaagggg gagccttgtt gaaaccattt gtatttatca caaaaccgat 2962861 tcctgaagag attgaagcat tcatcggtga acattgccgt tatgaagtat ggcaggagga 2962921 tacgcttccg agtgacgtgc tatttgaaaa attaaaagaa gcggaggggc ttttaacatc 2962981 agggacgtcc ggaccgtcaa tcaatcgtga gttgctggaa cacgcgccta agctcaaagt 2963041 ggtcagcaac caatcagtag gctacgataa cttcgatata gaagcaatga aagaaagagg 2963101 agtcgtcggg actcatacac cttatacact ggatgacaca gttgcagatc tggctttttc 2963161 actgattctg tcttccgcca gacgtgttgc cgaactggac cgttttgtca gagcaggaaa 2963221 atggggaacc gtggaagagg aagcgctttt cggaattgat gttcatcatc aaacgttagg 2963281 cattatcggc atgggcagaa ttggagaaca agcagcgaga cgcgccaaat ttggttttga 2963341 tatggaagtg ctttatcata accgacatcg caaacaagaa acagaagaca gcatcggcgt 2963401 taagtatgca gagcttgata cattgctgga gcaatctgat tttattcttc tcattacgcc 2963461 gctgactgat gaaacctatc acatgatagg agaacgcgaa tttaagttga tgaagaattc 2963521 agcaattttc gtcaatattt cccggggaaa gacagttgat gaaaaagcac tgattcgcgc 2963581 tcttcaggaa ggctggatca ggggagccgg cttagatgta tacgaaaaag agcctgtcac 2963641 ccaagataat ccgctcctgc agctggataa tgtcacgctg cttcctcata tcggttcagc 2963701 aacagctaaa gtgcgcttca acatgtgcaa acaggccgcc gaaaatatgc tcgcagcgat 2963761 ccaagggcaa acaccgaaaa atcttacaag agaatttcaa taaatcaaaa atccggtctg 2963821 ataacagacc ggatttcata ttacatacgc tgaagaacag cacgcttata aatatgacgg 2963881 gtgacgatat aataaagagc ctggaataca aaataaatga agatgacaat tacggcctca 2963941 agaaataaat tggaattcag catattactt aacgctgcat acgcaaagcc cgcgtgaatc 2964001 gtacctgcga taaatgggat gaagaataaa aatcctattt gctttccaag gatcgagtga 2964061 atctctttgt ccgtaacccc tatcctcttt aacgctaaca cctgcactcc cgtatcttct 2964121 atttccgtaa acatccgcaa atacagcatg cttccttgca cgataaaaaa cagcacgctg 2964181 acaaacagac caataaacag cattaatgca actccctgct tcacaatttg ataactagga 2964241 gcacgtgttt gaaaatcaga tgtatgttct ttcggcacca tgttttcaag cttttcagag 2964301 acatccaccg tctcctgcca atgctcaagc tcataaccta ccattctcat ctgttccttc 2964361 agcggcacat cctgtgacag actgtcaaag ctcttttcgc tgacaaccaa taaacggctg 2964421 actccatcga cagacatcaa tatccctttg ttttgctgct ttttcatgac ataggaaagg 2964481 gtttttcctg acttcatatg aaatgctgct gtttcccctt ctccaaatgt gtctttcacc 2964541 atcatttgaa aagaaacatt aataaatgct tcattttctt gtaaatgaat aactgggaac 2964601 cctttttcct ttgcgacttg attatagact ttttctgaaa tcagcaaagc ttcagcttcc 2964661 atcttcttat ttccatacgg caagtctgac tgaaaagtga caggaatccc tgtggcatcc 2964721 accttatacg tgataacagc atgagctttt ttcaatgtat tctcagccgt ctcaggcttc 2964781 atgacctgaa agcgggaagc atccttttcc acccaggaaa cagactgagg aatgctttgc 2964841 tcctcctgcc tttgtaaatc ggaataaaac atatagatga cacctgtagc tgttagtatg 2964901 accgctgtaa tgacagaggt taaaaacagc atgcgtgcat gatccttcag cctgaatatc 2964961 atgttggaac gcacaatgat atttgtgcct ttgtagaagc tgtgtttctt tcggtacagc 2965021 atgcggaaaa atgccacact gctttgggta aaaaagaaat acgtgccaat taacactaaa 2965081 atcaaaattg gaaaaacccg aaacatcatg tcaattgcat tggctgttgc agatagataa 2965141 taaccgctgc caagacatag caaagacaat acagtgagcc atttcgaata aactggcaaa 2965201 cttttcggct ttttggctga tttaatcagt tcaatgattt ccagcttccg aatccgtccc 2965261 agtgataaaa tgagcagcgt ctgaaacagg atgagaaagc cggcaattgt catcacaaac 2965321 gctttcggca caatggcaaa cgaaatcggc accttcacgc tgagcatcca tgtcatgatc 2965381 ataaaaaaca gttttgaaaa taacaggcct gctccaatgc cggccgcaat cgccgcaaga 2965441 gaaataagtg actgctcata ataaatcatc ttgcgaagct gctgctttga tgtgccaaac 2965501 agtgtcagca gcccaaactc tttctttctt gcctgcaaaa acgctgaatt ggaatatgtg 2965561 atgaaaaata tacaaaacac aatgatgacg acaagagctg cgctcaagca tgttttgaca 2965621 aggcttcctc catatatatt gtcttcattg acatcaggat gaaaaataaa tgatgtgaag 2965681 acaaaaaaca ccgaaacggc aaacacacag cttaaaaagt aggccacata ccgttgcaga 2965741 ttcccaagaa tgtttttacg ggcgatagtt ctcaaattca tgaaaatcgc ctcccaacac 2965801 actcaaggta tccaatatac tttgataaaa cacctgcctg tttgttcctc tgtgaatctc 2965861 tgaaaagaaa cgtccgtctt taataaaaac aatccgttta cagaaacttg ctgctgtggc 2965921 atcatgcgta accaacaaaa tcgtcgcttc cttttcctca ttcagctgag ccagtgtgtt 2965981 catcacttgc tttgccgatt ttgagtcgag gtttcctgtc ggttcatcgg caagaatgag 2966041 cgccggattg tgaataatcg ctctggcaca agctgcccgc tgctgctgtc cgcccgacac 2966101 ctcatatgtg cggtgatcga gaatatgctt tatttgcagc gtatccgcca gttcatccaa 2966161 tcgagcttcc atttctctca gctttacctt atccaatgcg agcggcaaga gaatattttc 2966221 acgaatcgtc agcgtatcaa gcagattaaa atcctgaaag acgaagccga gttctcttct 2966281 gcgaaacaaa gccagctctt ggtcctttaa cgttttcggc tgaatgccgt tgatcatcat 2966341 ctcgccctgg gtcggcttat caatggtagc cagcaaattc aaaagcgtgg tttttccgct 2966401 tcccgacggc cccataatcc cgacaaattc tccttttgac acactgagat caaaggcgct 2966461 gagcgcttgg tatgatattg ttcctttatt tgaatagtat gttttcgata ggttcgttgt 2966521 ttgcaacacg ttcatgttct gctcctcctt tttctttatt ataaaaagga agtcagcatc 2966581 ctcccatcga actttcttgc aattccgctc cccaatctta caatgctgtc acattcacga 2966641 gggtgtcact tgaaaacacg atggtcatca cagtgccagc cccttctttt gattccgcat 2966701 acagcttatg gccgagacgg ctgcacacct gttttgctaa ataaaggccc attccagttg 2966761 cctctttcat ggttcgtccg ttttctccgg taaaaaacgc gtcaaaaatc cgcggcagat 2966821 cctgcggcgg tatgccgatt ccttcgtcgg caaccgacaa gcgcgtctca tgtccctgtg 2966881 tttcaatccg gattgtaata gggtctccca caccttgctt tgaatatttt aaggcgttga 2966941 aaaggatttg ctcaacaaca aaggaaagcc acttttgatc actggaaatc tgaacggcat 2967001 ttggcggcac atgtaatgtt ggaaaaaggc gccgcttgat aaactgacgt ttttcctgat 2967061 tgatcagtga acgaaccatt tctgccaaat caaaggtttg cggctttaca tcaaatgcaa 2967121 attcctccag ccgggccgtt tgcagcatca tatcaagacc gtggcgaaat ctctcattct 2967181 catcctccag ctcctctaaa aacgtcggaa aagaggatga ggttccgttt tttccttcct 2967241 gaatcattaa ggatatgaca gataccggtg ttttcatatg gtggacccat tggttggtga 2967301 aggtgtaatg ctgtttttgc tgattgatat attgtgagag cctgctttcg tattgctgcc 2967361 cgagtgcgtt gatcatcttc gtccaaagcg cttgctctcc tgttcttggc tttctggctt 2967421 tcaaagactg tccgatgtca ttcgaagaag aggcttgttc tgcaagcttt ttaacatatg 2967481 tgagaaagga aaattgccga acataatcag cagcaaaacc tgcggctaaa agagtaccgg 2967541 gcaaaatcca tatgtacatc atattttctt tggaaggttc tgcgccgctc tctacaatgc 2967601 ttaaatacgc aatcagcatg gcggacccta tccctaataa tgaaaataga ataatggcta 2967661 agcggtcgat gagataagtc tttaacattc cgcttcatcc ttccgattga cttgaaattg 2967721 ataaccttgt cctctgattg tggaaatgca atctgtcagt cctgcattct ccagttttct 2967781 ccgcagccga ttgacattga ccgttaacgt attgtcatcg acaaaatcaa cgtcatccca 2967841 taacgcctcc aatagttcat cacgagagac aattttttta tgctccctca caaaaatcga 2967901 gagaagctgg aattcttttt gggaaaacaa aatccggacg ctgttccatt cggcctcatt 2967961 ctgatcagga taaatcgtca gcccgccaag ctccactatt ctagattcct gcggcaaaga 2968021 gggcgaatat tcaccatatg tgcggcgcag gacgcttttg attttggcca tcactacctc 2968081 tagatggaac ggctttgtga tataatcatc gccgccattt tcaatcgcca ttacctgatt 2968141 cagctcatcg gtccgtgccg atataaagat aatcggcgca ttggaaatgg tacggatttg 2968201 cctgcaccaa taaaacccgt caaaaaaagg caggttgata tcaagcagca caagatcagg 2968261 cttcatttct gcaaattcca attttatatc attcagctgt tcagcaattt tcacttcata 2968321 tccgtatttt tgaagatgac cgcccagcaa agaagcaatc cgctcatcat cttccacaag 2968381 caaaatccga tacacgttga tcccccttat atgtacatca cgatgatttt tctagaagat 2968441 tccaaaatta ttatagcatg tgcggaatag taaatcggtc tttttctttt tgttatgata 2968501 gaatgataaa ggtaaaattt tcataatagg caggtgtcgt gatgaagaaa atcatgctgt 2968561 ttctggcaat gacgtcaatt ctttcagcat gtcagcccaa ctataccggg aaatacatag 2968621 aaattgggga tacactaact gactatacca aagagtgctt taaagagaat gaaattcctt 2968681 ataaatacga aaagggaaaa ctgtatatcc cagaagacgc atttgataca gcaatctaca 2968741 cttgttcata agaaaaagct tgcagataac ctgcaagctt ttcacgttac aaaaaatgag 2968801 tatttaattt ctcttcaaat cctgaagggc cgatgtcgct tttttgaatg ttaccgccgt 2968861 tttcataaat cgtaaaatgg cgctctgaca tgaccatcct tccgctcggc gtcagctttg 2968921 aggcaagcag ggatttgtta aaaggagatt tttcatgaga gtgaatgatg tccttcatgt 2968981 tatctaaatc accgagatca ctctcttcaa gggtaaaggc gtacccaatt tgccagcctt 2969041 ctcctttgtc catcagcaga acatagctgc ccttttctgt ctcttccttt ttgattcgga 2969101 atgacccgac tggtgactgt accgtttctc cggaaagcgg tatcggctgg agcgccaggt 2969161 tgatgccgaa gccgatatca acgaggtaat cgccgttttc cgcagacagc catacagcag 2969221 catgcgtccc ttctagtgcc catccctctt gatcgcctgc ataaaccgtt cctcgaatga 2969281 gcttcacatg aaacccggcc tcacgcaaga caaaataaag gaaaccattt agatcgtagc 2969341 ataggccgcc gtgctgatct ttgagcagac gtcgccatag ctcttctttt gtgatcttat 2969401 aattctcttt tgcaagtacg gcacggtttt cgaatggaaa acggtatgcc attgctttaa 2969461 gaaaaagggg aagatcgccg aagctgacat ggtctttctc ccagccgatt ttctgaaagc 2969521 agtcttttag aaagtcactc atttttatca cctaaacttc ttcttgaacg taagcagcca 2969581 gcttctccag cgcctcttgt tcatcttctc cctgggcaat caaggtaacc tcagtgcctg 2969641 tgcttaccgc aaggctcatc agccccatga tgcttttggc gtttactttt ttcccatcct 2969701 tctcaagaaa cacatctgac gtaaaccggt ttgcttcttg tacaaacaaa gcagcaggac 2969761 gtgcttgcag tcctgtcttt aatcgaactt ccactttctg ttgaaccata agatctcccc 2969821 ttttctttac ggttatttta aagtgacggt ttgccctgtc cgcagctgtt ctgcgatttc 2969881 gtcaagtttt ctcagcctgt gattgatccc tgatttgctg attttcccgc ttgctaccat 2969941 ttcccctagc tctttcagcg tcacttcctg ataatcaatc cgcagctgcg caatttcccg 2970001 aagtttttca ggcagcgcct ccaggccgat tctttcatcg atgtatttaa tattttccac 2970061 ctgtctcagc gatgcgccga tcgttttgtt taagttggct gtttcacaat tgacgaggcg 2970121 gttgaccgaa tttctcatgt cccgaacgat tctgacatcc tcaaatcgca gaagcgaatt 2970181 gtgagcgcca attacgttca gaaactctgt aatcttttca gcctctttta aataggtaat 2970241 atagcctttt ttccgttcaa gcgttttgct gtttaactga aactcattta acaggtcaca 2970301 taatgaatcg ttatgctcct tataaagaga gaagatttct aaatgatacg aggaggtttc 2970361 cgggttattg accgaacctc ctgccaaaaa tgctcctctc atataagaac gcttgcagca 2970421 tctctttttg accagctctt tcgaaatact tcgttcaaac acaaaattct ccccgagtat 2970481 ttttaaatcc tctaagatcg cttttgcatt ttctgaaaaa cgcacaatat agacgttatt 2970541 ctttttcagc cgcattttct ttctgaccag cagctcgacc gacacatcat attgtttttt 2970601 cagcaatgta tagatgcggc gggcaatcgc cgcgttttcg gtttgaacat cgagtacgag 2970661 atggcggttt gtaaatgata aagctccatt catccgaatg agtgcagaca gctcggcatt 2970721 aatgcagcag tccttcactt ccagattcgt taattctttt tttgtttctg atgcaaatga 2970781 catatagcca cctcatttca aggcttcatt ctttcagtaa atcaacaaga agagaggcca 2970841 ctttatgtgt atcgtgacgt attacgtcat ttttatacgt tacaatttga tctctgatga 2970901 cttcaagccc catcgctttc agctcttcga tatcaaaatc aacaggacgc gccgattcca 2970961 tttcgtactt acgttttatt tcgtcgggaa tgtcttcact gttcactaat atcgtatcaa 2971021 taaaaccaca gcccatatgc tgattgagcg ctttcacatg atcagcagcg gtgtaatgga 2971081 gcgtttcgcc gggctgagtc atcacgttgc aaatgtatac ttttttcgcc ggcgccttta 2971141 tcacttcttc cccgattttt gggacgagca aattgggaag aatgctggta tagaggcttc 2971201 ccgggccgat aataatcaaa tccgcttccc tgattacgtc tattgtttcc ggcagcggat 2971261 caatctgttc aggcgtgaga aaaacacgct taatgcgctg tccgtattct gggatcgttg 2971321 actcgcctga gaccacgcgg ccatcttcca tctcagcatg caaaacgaca ctggcattgg 2971381 cagccggcaa aacctttcct cttacattca gcaccttgct catttctgtg acagcgtgaa 2971441 aaaaatcacc ggttatattt gtcatcgctg ccaaaatcaa attcccgaga gaatggcctg 2971501 ttaagtcatt ccctttattg aagcggtgct gaaaaagatc ttcaacaagc ggctccacat 2971561 cggataaagc ggcaagcaca tttctgatgt ctccgggagg cggaattttc agttcattcc 2971621 gcagacggcc agagctcccc ccatcatcgg caactgttac aatggccgtg atgtcaacgg 2971681 gtttatgctt taggccccga agcaatacag aaagacctgt accgccgcca aagattgcga 2971741 ttttcggctt ttgtcccatc ttatttccgg cttctctttt caatgtcccg gtgagtaaca 2971801 tgagtatagt aatccttttt gaaataatca gctaaattct cggctaatgt cacagagcgg 2971861 tgctggcccc ctgtgcagcc gatcgcaatg acaacctggc tttttccttc tcttttgtaa 2971921 gatggaagca taaagctcag cagatcaatt aatttctcat tgaacttttg cgtttcattc 2971981 cacttcatga cgtaagagga aacctcttta tccttgccag tcagcggccg catgctttcg 2972041 atatagtacg gattcggcaa aaatctgaca tcaaagacga gatctgcatc aattggaata 2972101 ccgtatttaa aaccaaatga catcacattt acggtaaatg tctctccttg gtttgtcgca 2972161 aagtgcttca cgattttttc acgcaaatca cgcggcttca tgtcagacgt atcgtaaatg 2972221 atttgagagc ggccttttaa ttcctcaagc agctctcgtt ctagcgcgat gccttcaagc 2972281 ggcaggccag tcgctgccag cggatgcgag cgtctcgttt ctttatatct tgtgacgaga 2972341 atggaatcct tcgcgtccag gaataaaatt cgcggtgtga tccacggatt ttcggccatt 2972401 tcatccagcg cttcaatcag ccggtcaaaa aattcgcggc cgcgcaaatc catcacgagc 2972461 gcaactttgc tcattttcga atttgattcc ttcatcagct ctaaaaactt cggaagcaat 2972521 gaaggcggaa gattatcgac gcagaaatag ccgagatctt caaagctttg gatcgcgaca 2972581 gttttccccg ctcccgacat tccagttata atgacaagct gaatatcatg tgattcacta 2972641 acactcatct ttctcccccc tgacttgtct ttctatttga tgtgctgcgg gtctaaacga 2972701 taactgagca gctcaaattc cggtgtatac gtaaatgtgc cgtgcagcag cccttgtccc 2972761 ttcatcataa aatcaaggat atggccgtct ccaggggcca taggcaggtt ctgaatgtca 2972821 ttgacatcgt gccactgcag tttgccttcc tctgattctg atacattttg tcctgtatat 2972881 gaatcagcga caaacgtaaa catcatccac tcggagacaa tgtggtcacc gtctttaata 2972941 ataaaggtaa aaacgccttt taattgagga tttatgatat agataccagt ctcttctctg 2973001 tactctctga tgacggagtc tctgactgat tctccgctct ccatcttgcc tcccggcgcg 2973061 acccaccatc cgcgtctcgg cttttgaagc agaagaactt tgtcatccgt ctgaagcaca 2973121 caatttgtca ctctttgcaa gtacgtcacc taaccttcgt cctgtcatcg tctctttatt 2973181 ataccgcttc aagatgcctc ccacaatgaa gagacattga caatcttttc ttctatttta 2973241 cagcatattc attccttaat tcagatgatt ttgctgtaac tggaattctc ttttatttat 2973301 ggacaaaaaa aggacacgga taactggaga atccgtgcca aaaaagtgta ttcattataa 2973361 aaagggggtc aattacttta ttaatcataa ccgaaaagca ttacacatgt gttacagcgg 2973421 aattaaaacc cagtaacgta atgtgaaact cgtatgacag ccctttttat tttaaggttt 2973481 tcagcgtttc ttggagctct tcgacataat gttgtacgct ttgtgccgca atgcttccgt 2973541 ctcctgtagc cgttacgatt tggcgcagtg atttttcgcg gatgtctccg gcagcgaaaa 2973601 tcccttcaac cttagtttcc atgcggtcgt ttgtttcgat atagccttct tcattcgtaa 2973661 tgcccaggtt ttcaaacggt ttagacagag gaagcatgcc gatgtaaatg aatacgccgt 2973721 ctgttttgaa ttcactttct tcaccggtta ccgtatcgac aagcgttacg ttaccgactt 2973781 tgccgttttc ctcatgaatt tccttcacag ttttgttcca taggaagtca actttttcat 2973841 tatcaaatgc tctcgcttga agaatacttt gagcacggag tttatcacgt ctgtgaacaa 2973901 tcgttacttt tgaagcgaaa cgagtcagat atacgccttc ttcaaccgcg gaatctccgc 2973961 cgccaacaac gacaagttct ttgcctttaa agaaagcgcc gtcacatact gcacaataag 2974021 atacaccgcg tccgcccaat tctttttcgc caggcacgcc gattttttta tattccgcac 2974081 ctgcagcaat gatgacagca cgggctttat attcctttga accagctttg actactttgt 2974141 actctttgcc gtcaatgacc tctttaatat cgccataagc gtattcagcg ccgaattttt 2974201 tcgcgtgttc aaacattttg ttagaaagct caggcccaag gatactttcg aatccaggat 2974261 agttttctac atcttccgta ttggccattt gtccgccagg aattcctctt tcaatcatta 2974321 atgtcgataa attcgctctt gatgtgtata cagcggccgt catcccagca gggcccgcgc 2974381 cgattataat cacgtcataa attttttctt ctgacacact attcactcct taaaccatct 2974441 tttcaagttt gggctctttc ttataagata agaatcccca tcaaacgtat tccttaccca 2974501 tatcctataa aatctcatgg tgatacgcta tttttttgct caacacgatt aaatgtattc 2974561 gaaaagggta tatgttaata aagaaagagc cttctgttta tagaaggccc ttgtcatatt 2974621 tattattgaa caacacgtct tacaacacct ttaaatgctg ctttccagta aggattgctc 2974681 atagagtcaa cagatacgcc atgagatgta ttgtcgttta ggaaagtacc gtttcctaag 2974741 tagattccta cgtgtccatt tgttttgtaa gtgtcaaaga acacaaggtc tccgcgtttc 2974801 atttcagacg cgctgacagc ttgtcctctg ccaactaacg tatcagttgt tgttccgcct 2974861 acaggtccaa ggttaacacc tgcagaagcg tatgcccagc gtacgaatga tgagcagtca 2974921 aaaatacggt tgttgatatc agactgagtg cgtccgccgc caaacttgta cggagattgt 2974981 cctacaatgc ttgaaccaac gctgatcgcg ccttcaattc cgccagagtt gctgataaca 2975041 gtgccgcctg aattgctgtt tgagccgctg ctcttcttag aagatgagcc gtttgacgaa 2975101 ctgtttgatg aaccgttaga agaattgtct gaagaattgt ctgaagaatc atcagatgag 2975161 cttgcttttg atgattcagt tgtcgccgtt tgactgtcat ctgtttgtgt ttcatcagat 2975221 gctttttgtg cttcttcctg ctttttgatc aaagcagccg ctgcttcttg ttcttttttg 2975281 atgcgtgctt gttcagcttc agtatttgct ttttgatttg caagttcaga cgcctctgat 2975341 tttaattcag aaatcgcttt agccgttttc ttttggcttg cttttgcttc gtcgaaaagc 2975401 ttgtcttttt cattaagctg tttatcaagg tctttttgca ttgtttctaa tttagccaag 2975461 gcagcttgaa cttctttcag cttgtcattc aaatccgctt cagaatcttc gagcttcgct 2975521 ttatcctgct cttgctgttt gattaaatct ttgtctgcgt ccacaataga tgaaaccgca 2975581 gtcgcacgag agataaagtc accaaagctt gttgatccta aaagaacatc tatgtatcct 2975641 tgagatccgc cgctttcctg taaagaacga acgcgttttt tcaggatttc attgcgtttt 2975701 tcgatgcgtg cttcagtttc tttaatctct tttttcagtt ttttgatttc ttcttttgtt 2975761 ttatcgtttt cttctttttt atcttcaatc ttgttgcttg tatcaagcgc cttatcgtta 2975821 atgtctttca gttctttttc aatctttgat tgattttcct gaagctcggt taattctttt 2975881 tccttcgctt caatgctgga agcaacctca gattgcttgc tttcgatttt ttgtttcttt 2975941 tcatctaatg tttccgccga tgcagtttta cttgtaaatg ggatcaaaaa actgcttgtc 2976001 ccgatgacgg aagccaaacc aagtgtaatt aaactctttc tcacttttta tatcctccct 2976061 tttactgtga acctgtcctc atttggaatc gtattttgaa catcaagttt cgttcctcat 2976121 actctacgag gaatgatggt tgtttatggt taattattct gtgcatctct tattctggtt 2976181 gtatagcgtt tatttcacat catatgtaaa aaacactaat tccttatgta cgagaatcat 2976241 tataccatca agtttcgaca aattagcgat aaattttatt acatttatgt ttcaaacaga 2976301 tgtcaagtca cacatcattt gtcatttttc ttaagcgtgt aaaaaaactg tcgatattat 2976361 tttcttaata taatctatct aacaaaaaaa gagtcgatta aataaatcaa ctctttaaaa 2976421 tttactattc tagaatatca tcaatatatt tcatatattt cgtcaaagtt gccggagaga 2976481 tgccgaatcg ggccgctgtg tcttttttcg tgtcttgctt gccatgggct tctttccaaa 2976541 tataacagat ggctgctgcc cagcctttct cattcttcaa cggagcagct gcacgaattt 2976601 gctggatgac atgaaaaacc cagcagctca tgacttctgt tttcatctct tctttttcag 2976661 cttgctctaa tagtttgacc gtttgataag cgaaaagtgc atcctctgaa acgtcagcag 2976721 ccgcagaatc tccattcaga agcagcttta caaaatgagt ttcaaaagga gcggtaattc 2976781 tctttgagcg tatcaccgct tcaagatgct ctgtttctcc ctttgtgctg ctgatataat 2976841 aggctgcgag tcgctgctcc acagatgaag gaagagcttc cctccgctca atccaaggcg 2976901 ccgggcggtc ttcgccggga tattgcgact cgacttttct ccagatcgtc tcggcaaagt 2976961 cggtatgtcc cgtaaaataa gcagagcagg aaagccagta aaagaaggtg tcgtcaccct 2977021 caaagccggt tttatataat gatttgagcc atttatatcc gatctcgtag cggccgacaa 2977081 gcgccaaagt agcacccaat ttataacgct gctccaatag catcggatag acattggaga 2977141 gctgatcact caattccgcc actttttcgt cttctctttc ataatagtag aaaacgagaa 2977201 gattgcataa ggcgtgaaga tttccttcat tatgagaaag cacttcataa gcggtttgct 2977261 tcgcttttac aacgtttcct gaatagaaat aggcaagcgc gagattgttg tatgctgacc 2977321 aaagctccgg atattcagtt gtgatttcct caagcgccgc aaccgcttca gcaagctggc 2977381 cgctttccag caatgacttt gcccgatcct gtttcaccag cagttcatcc tgatcataca 2977441 acgaatcctc aatgccgtcg tctcctaaat cgagcaaatc aagcagacta tcgttttctt 2977501 cggcgaattc accatccggg tccgcatcag aataagcggc cgcttcttta taagcttcct 2977561 ggaagagccc cagatgggca aagttattcg ctttaaagta atggcactcc ggcatttcgg 2977621 cctccagatt tgccatgata tagtcaagaa gatcgttcga ctcttgatac tggcccattt 2977681 ccgaataaat gaccgcaagc tgtgaaagca tctctgaatc ctccggctcc aaatgaaccg 2977741 cgcgctgaat cagtttgctt gcccgtttta gattgcgctc tttatacgct ttcaagcctt 2977801 tatgaaaaaa atattgtcca tcttgaagca gctggacaat ttgtgcgtga tttttatgtt 2977861 cagaagtgtg ttttcccaca actaccctcc gttttataca atattaccgt cagtagtata 2977921 ccataaatcg taagcccctc aatagttcaa aaggaaggat tgggaaaatc cctcctcttt 2977981 tttattggct gattcgacca aaatttaccc ggctttgttt tctaagtccg cattcatttt 2978041 cagctgctgt tcagcaaaat cccggtaaag gccatgggaa gccattaact catggtgtgt 2978101 tccacgaccg gtaatttccc ctttttcaac aaacaaaagc tggtccgcat ctacaacggt 2978161 agataggcgg tgagcgataa caatcgttgt gcggccctcc atcagcacct ccagcgcctg 2978221 ctgaactgat ttttcagatt ggctgtcgag acttgaggta gcttcatcga gcataagaat 2978281 gcttgggtta cggagaagcg ctctcgcaat cgcgattctt tgcctttgtc cgcctgacag 2978341 cataatgccg cgttcgccca cttctgtatc aaactgattc ggcagctcct ttataaaatt 2978401 gagcgcatat gccatctccg cggctttttc gatctcagca tccgtcacat ctcgttctaa 2978461 cccgtagcaa atattttctc tgattgtccc ggacattaac gggctttcct gtgatacata 2978521 cccgatatgc tccctccacg attcaagcga gtaagtatcg accggctcgt cccccagccg 2978581 aatggtccct gcagtcggag aataaaagcg ttcaagcagc ttaaacagcg tcgtttttcc 2978641 cccgccgctc ggaccgacga tcgctgtcac tttccctgct tcaatgacgg cgctgacctc 2978701 ttttaagatc agctgatcag gcttatatcc aaaagacacg cgatcaagct ggataggcag 2978761 atgtgcattt tcaatttgtt ttcctgtcac tgtatcttcc tcttcctctg ccaaaatctc 2978821 aatcattcgt tctgttgcac cgattgattt ttgcagctgt gtgaaaaacg ttgtaatctg 2978881 gcccatcggc ataataattt gaaacaaata taaaataaaa gccacgagcg ctccggctgt 2978941 gagctcgcct gatgagacct gcatgccgcc atatccgatc actgcgacaa gcgctgccat 2979001 taacacgagt gaaataagcg ggccgacaag cgattgaacc ttggcttcac gaacgccaag 2979061 cttaaataat gaggaaatcc ccatcttccc gcgcccatat tcgacatcct ccgcatttga 2979121 agccttaaca agtctgattt ccgggagaat ttgattaagc aggcctgtaa aacgagccgt 2979181 ttcatcttgc gtttcccgtg aaatggagaa cattttccgt ccaatcggca ccaaaataag 2979241 agcggccagc ggaacgacca ctaacacaag cagtgtcagc ttccagttca taataaacaa 2979301 gattgtcaat gatccaatga cagaaatgat gcctgtaata aatccgctga tatgggttgt 2979361 aatcaattct ttgaccacca tcgtatcgtt cgttacacgg ctgactgttt ctccggaagc 2979421 atttgtatcg aaataagaga caggcagctt aattaatttc ttccataata actcccgcag 2979481 cccggaaatg attttttgtc cattatagtt aagcgcatag gtggcataag cgcttaaacc 2979541 cgcctgaacg aaaaacacca gcgcgatcaa accgatttgc gtgcctgaca gatttgacat 2979601 agaaaaacca tcgacaagct gcttcgttaa taatggaatg agcaggctga ccagcgtggt 2979661 tactacactg agggcaagcg caaaggcgag ctttccataa gaaggattgg tccgtcttac 2979721 taaggcaaaa aagggtttca atttactttt agatttttgt ttcttggttg gcatatattt 2979781 tcctcctgtt tcagcgttca gaaaggtgaa aagtcatagc aaaaggatga tttttactct 2979841 ttctcaatca tatcaatgga gaaagacttt ttcagtatat ttttgccgtg atcaaaataa 2979901 aaatctccca ctcattgttt gaataggaga tttttgtgtt agacatcttt cactggcttc 2979961 ttttttctgt aagtcaatgt tacatcctgc tgtcgcaggt cttctattat cattttgtac 2980021 cgatcaactt ttgcggtatg ttcttctttt atcatctgaa gggcagcttt tcgtttttcg 2980081 ctattagact caagctcttt ttttattttt tttacaatca accctttttg ccctttgatt 2980141 tcctctttta atgaagactc aaatttcttt gtcaggctga gaaagtcgtt gatcggttga 2980201 ttgagggtgc ccgctttccc cttcatttca tcttgggtaa gaaacatata ggtcgttgat 2980261 acaatttctg tttcactttc tgaaaataag gaagtcactc ttcatattcc tcctaagact 2980321 gaaaatcaaa taactgagaa atcatttctt ctttttcaaa cagcttttca atactctcgc 2980381 ggatattttt gataaaatct cttttttctg ttgtctgttt ttttaattca gcaacaattc 2980441 catcatttgc aggaagcgca cctgtgtgga atgattcatg aactgagatt ttctccaatt 2980501 tatcgaatgt gtggctgaaa ccagctgcaa gccggaattg aagatcgaag gcataatgcg 2980561 aagggttttc ttccatatga tgaatagccg tgatgatcgc ctgctttttg tctatgaagt 2980621 cttcatcgat ttcctgactg taaaccttct ggtacttaga aatcgcatct tccatatctt 2980681 caacgatttt cataccgttt tgatagattc tgacagcgga tgagagattg acttgaatcg 2980741 tttctcccga gccactcttc cctgtaaaat aaatatcgga gcctttatag ctgaagcctt 2980801 tttcctttga caaggcgttg agcatttgaa cgatgctgtg gccgtcgacg ataagtttta 2980861 gtgcgtcttt tgtttctgtg tcgagtgttt tcaatgagga cagaattgat tttacatagt 2980921 ccactatttc accaacgtct tttaaagctt gcataaattg gccatgtttt agatggtcta 2980981 tgaaatgttc gtaccgtgac tctatgcctc gcatactcgc attaatattc gttaattctt 2981041 ttttgatgac tttcttttgc gtttcatcaa tataaccatt ttcagctaac tgatctacga 2981101 ccggtccgct gtttctcaac aaggtatgaa gaaaacctaa aaacgacggc agttcctctt 2981161 ttattcggcc atacatttgc ttaacatcat caaaatgctc atataggaca cttactttct 2981221 ttaaagcgcc gtctgtgttt ttcacttttt caatcaggtc tatgtctatc ccgctggctg 2981281 cctttataaa accgttcaag ccgtcttttt catagtcatc cttatatttt tgaaggaatt 2981341 tttgaattga cctcacatct tcgtcaggaa ccccatccat aatgtttcgg atgcctttta 2981401 cacttgtatt tgtatctgcc atcttcacat caccgaatgt aataaaatcg gccttgccgc 2981461 tgactccata cagcgggtca tcttttgaga tgcgctgagt gatgtttgtt gttacgcctt 2981521 tgtcttcata atatttttgg atttcttttt ttaacttttc tggcgggatg gaatctatat 2981581 cttcatattt ataactaaat ttcctaataa catatctata taaactttca tcagtttcaa 2981641 gtaattgatc aatattgact tgagctccat ttaccccata aacttcatca tattctccat 2981701 caatcaattg caccataact tggttattat ttgcaagtga atgtcctaag gcgaatgttt 2981761 ttaaatcctc agagttacct gctgctttct ttgctttgtt agtaaactcc tttgtagcct 2981821 catactgact atgatcaatt cctaaaaaaa gaccaaaaaa gttatatgac caatccttat 2981881 tatcggcact accttctgaa ataatctgaa gctgatcaat atgttttttc tcatctatta 2981941 tatggattgc cgttccatcg taacctgatt ctctggtcga actttgtata cttgtattct 2982001 gatttacaag ttcattggag gtgtaaattt caattttcat attctcagga agatcgtggt 2982061 gggtttcctc tttataaatt ctgcgtatat ctgcttcgaa atccttctta gctttcttaa 2982121 cttcactcgc aatagttgag gcaaactttt gtttatagtc atattctaaa tcaattaacc 2982181 ttaactttac gttctcattc tcaaatacat ttttatttcc catcttattt ctccttttta 2982241 tctattaaaa aggtgataga attaattaat ttctcaactt tatttttagc cttttcttca 2982301 tctaaggagc atggttgatt ttcatttttg catccaaggg taaaggcgta ttctactcct 2982361 aggttatctt cctctgtaga cttaacatat ccaaaataac tgtatgaata attatatttt 2982421 ctatcaatat cgtcaaagat gtcttttttc ttggcagtgt aaatatccgt tttctttttg 2982481 ctgctttttt tgtattcgcc tttataatca ttttttccac taacaatatc tagcattgtc 2982541 ttaggttcat tcgcaaaact ttcttctttg taatatgtta catggccatc aaacattaca 2982601 ttggtgtctt tatcataact attaaatcca atactttctt tgtttttccc ggttaacgat 2982661 gatcttcttg atagatactt tccatcctcc ggaaacaaca tcctaaaccc tttcagctta 2982721 gattccagca aataatatcc tggttcctct tcttttgttg acaccatgta ctctctcgtt 2982781 ttctcgtcct gaaacgcagg tacttgaggc agatccttgg gatccccgct agctttttat 2982841 ttttaaaaaa ttgtcacagt catgtgccaa agtcctcttt actttcaatt gtatagggac 2982901 tgtaagcgtt ttaacataga gtcaaaggga agcatcattc tctgaacata tttcttaagt 2982961 gcagaaaaag gatggaggcc ataatatgag tcagaaaaca gacgcacctt tagaatcgta 2983021 tgaagtgaac ggcgcaacaa ttgccgtgct gccagaagaa atagacggca aaatctgttc 2983081 caaaattatt gaaaaagatt gcgtgtttta tgtaaacatg aagccgctgc aaattgtcga 2983141 cagaagctgc cgattttttg gatcaagcta tgcgggaaga aaagcaggaa cttatgaagt 2983201 gacaaaaatt tcacacaagc cgccgatcat ggtggaccct tcgaaccaaa tctttttatt 2983261 ccctacactt tcttcgacaa gaccccaatg cggctggatt tcccatgtgc atgtaaaaga 2983321 attcaaagcg actgaattcg acgatacgga agtgacgttt tccaatggga aaacgatgga 2983381 gctgccgatc tcttataatt cgttcgagaa ccaggtatac cgaacagcgt ggctcagaac 2983441 caaattccaa gacagaatcg accaccgcgt gccgaaaaga caggaattta tgctgtaccc 2983501 gaaagaagag cggacgaaga tgatttatga ttttattttg cgtgagctcg gggaacggta 2983561 ttagaaaaat aggtgtattt ggaagagaac gaaagcaagg aggagcagac gtttgaaccg 2983621 atcaggcaag catcttatca gcagcattat cctgtatccc cggcccagcg gagaatgtat 2983681 atcctcaatc agcttggaca agcaaacaca agctacaacg tccccgctgt acttctgctg 2983741 gagggagaag tagataaaga ccggcttgaa aacgcgattc agcaattaat caaccggcac 2983801 gaaatcctcc ggggatcccc gggtaccatg ggcccgcggc cgcctcgaga attcatcgat 2983861 acgtagccgg ctagcaccca atataaatct aaatacctat tacttttttc acaaaacaaa 2983921 aagagccgta tcatccggct ctttactctt caatctcaga atggcgtttt ttcaatacgt 2983981 caagcacatc atccagcggc agggattgtt ctctgagcag gacaagcagg tgatacagca 2984041 ggtctgccgc ttcccatttg agttcctcat gatcccggtt tttcgcggcg atgatgactt 2984101 cggatgcttc ttctccgact tttttcaaaa tcttatcgac gccttcacgg aagaggtacg 2984161 tggtgtaagc tccttcaggc atttccgctt ggcgttccgc gatcacccgc tccagttcgt 2984221 tcatgatgcc gaatcggtcc gcggcctgtt cttctgtttg ttcctttgta aaacagctgt 2984281 agctgccagt gtggcatgcc gggcctgacg gttctacgag tacgagcagc gcgtcttgat 2984341 cgcagtcata ccggatacct ttgacggctt gcgtgttccc tgaggtttct cctttatgcc 2984401 ataacgcttg gcgtgagcgg ctgtaaaacc atgtttcctt cgtttccagc gttttttcgt 2984461 acgattcctt gttcatatac gcaagtgtca gcacttcttt gcttgccgca tcctgcacga 2984521 tagcaggaat taatccgtcc tcgttaaaac gcagttcatc tgcctgtttc atctcacatt 2984581 caccccgtac tctttcaagt atgatttcac ttctttaatc gatgtttctt tataatgaaa 2984641 aattgaggcg gccagcgcgg cgtcggcttc tccttttgta aaagcctcaa gcatatgctg 2984701 tgcgtttccc gcgcctcccg aagcgataac agggacgggg acagcttcgg aaacaagctt 2984761 tgtcagcgtg tggtcgaaac cttttttctc accgtcggag tccatgcttg tcagcaatat 2984821 ttctcctgcc ccgcgtttga cgccttcttt tgcccacgcg gtgacctccc aatctgtttt 2984881 ctttctgccg ccgtgcgtgt agaccttata tgtgtcagat tctttgtcat acttggcatc 2984941 aatggcaagt acgatgcatt gagaaccgaa aaactcggct ccttctgtaa tcagctcagg 2985001 gcggagaaca gctgccgtgt tcaccgacac tttgtccgct ccggcacgca gtatcgtttt 2985061 catatcgctg agctgattga tgccgccgcc gactgtaaac ggaatggcaa gcttcgcggc 2985121 aacctgctcc acaacgtcaa ccatcgtctt tcgtccttcg tgcgaggcgg agatatcaag 2985181 aaaaacaagt tcatccgcac cttcccggtc gtacacttcg gcgagttcaa ctgggtcacc 2985241 ggcatccttc aattcgagaa attgaattcc tttgacaacg cgtccttctt tgacatcaag 2985301 gcatgggata atccgttttg tgatcatttg cgcttcaccc tttcaagcgc ctcactcagc 2985361 gtaaactgat tggtatacag cgcttttccg atgatcgctc cagagacgcc gtccgcctca 2985421 ttgcgggcga gagcttcgag atccgcgacg gagctgactc cgccggaagc gatcaccgat 2985481 ttccccgttt ccttagcaag ctcgaccgtg cttttaacat tggggcctga cagcattcca 2985541 tctgtcgcga tgtcagtaaa aataaagact tccgcacctt cattggctag ctctttgccc 2985601 agttcagttg ccttaagggt tgatgtttca agccatccct ctgttgaaac aaaaccgttt 2985661 ctcgcatcca gtccgattgc aattttctcg ccatattgtt tcagcatttt tttgacaaac 2985721 ggagggttag aaactgctga gcttcccagg atcacccgct cgactcctgc tgataaatat 2985781 tcatagacgt cattttcaga acggatccca ccgccgattt cgactttcag gttcagcttt 2985841 tgcgcaatct caatcacatg gcggtcattc actcttttcc cttctttggc cccgtcgaga 2985901 tcaacgagat ggatccattc ggcaccctct ttctcaaata actcagccat gtcgtacggt 2985961 gaatcgccat atatcgtttc cttattataa tccccttgaa caaggcgaac acatttgccg 2986021 tttctcatat caattgccgg atataatgta aaagcactca ttttttcacc ttctgttctg 2986081 ctgccatttt cgtaaattgg gttaaaatag acattccgac cgtgctgctt ttttccggat 2986141 gaaattgggc gccgaagacg tttctttttc cgactacagc aggcactcgt acaccataat 2986201 cggcgcttgc cagaagcgcg ttctcctcca tcccgtcaat gtaataggaa tgaacgaagt 2986261 aagcgtagcc ttgttctgtt ttagtcagca gcggagattc attatgaaaa gaaagacgat 2986321 tccagcccat atgcggaacc ttcagcttgt ttcctttttc atcttctgct ttcagcctga 2986381 ctgcttttcc ttttaacagc ccgagtcctg aagcggtgcc gttttcttcg ctttcttcaa 2986441 ataaaagctg catgccgagg cagatcccga gaagcagcct tccctctgag accatatcgt 2986501 gaatcaattg atcaagcttc gtgtagccca aattgtccat cgcgtctcca aatgaaccga 2986561 ctcccggcaa aatgaaagca tcagcttctt tcagctcctc cggcttttca gaaacaaaat 2986621 acggcacgcc gacacgttca agcgcctttg agacactgta taaattcccc attccgtaat 2986681 ctatcacgcc gatcatttac agcatccctt tcgttgacgg tattccttta actcgcggat 2986741 cgatcgttgt cgcttcatca agcgcacgtc ccagtgcttt aaaaacggct tcaatcatgt 2986801 ggtgggtatt tgttccataa tgaacgatga cgtgcaggtt cattcgagct tcgagcgcca 2986861 gcttccacaa aaattcatgt acaagctccg tatcgaaagt tccgacttta gcagccggga 2986921 aatcagcgcg catttctaag tgcggccggt tgcttaaatc aatcacaact tgagcaagtg 2986981 cctcatccat cggcacaaac gccgatccgt agcgtttgat tcctttttta tcgcccaacg 2987041 cttcgagcag cgcctgccct aagcagatgc cgatatcttc agtcgtgtgg tgatcatcta 2987101 tatcaacatc gccttttgcg ttaatggaaa gatcaaattg gccgtgtttc gtgaataaat 2987161 ccaacatatg tgtcataaac ggcacatctg ttttaatatc cgcttgtcct ccgccgtcta 2987221 ttgtaaatgc cagctcaata tctgtttcgt ttgttttcct gacgcgttcc gcttttctca 2987281 tttagaaatc ctccgttctc tcgcttcaat tgatctggca tgggcttcta acccttccag 2987341 tctggcaaaa gccgcgatgc tttcggcatg ttcttcaaag gctgattgac tgtaagaaat 2987401 aatgctcgat ttcttttgaa aatcagttac gtttaatgga cttgaaaatc tggctgttcc 2987461 gtttgtcgga agcacatggt tcggtccggc aaaataatca ccgacaggct cagggctgta 2987521 tctgcctaag aaaattgcac ccgcatgttt gatactgcca agcaaagctt ccggagactg 2987581 tgttatgatt tctaaatgct ctggcgcgag tgtattgaca gtctcaatcg cttctaccat 2987641 tgtttccgcc acatatatac aaccgtaatc tctcactgaa gcttccgcta tttctcttcg 2987701 cggcaaggtt tccagctgct tattcacctc ggctgaaacc gtctcggcca gcgccatgga 2987761 atctgtgaca aacacacatg agctaagctt atcgtgttcc gcctgtgaca gcagatcggc 2987821 tgcaatttcg ctcggaatcg ctgtttcatc agccagcacg acgatttcac tcggtccggc 2987881 aatcatatcg atatcgacat cgccgaacac ttctcgtttg gcaagcgcga cataaatgtt 2987941 gcccggaccc gtgattttat ccaccggctc aatggtttct gttccgtatg ctaacgccgc 2988001 aatcgcctga gcgccgccca ttttgtaaat gtcttttatg cccagctcgg ctgcagcaac 2988061 caaaactcca ggagacagca gaccgtcttt tcccggaggc gtgacgagaa cgattctttc 2988121 aacgcccgct acgagcgccg gaatcacatt catcaaaaca gatgaaggat atgcggccgt 2988181 tccccccggc acatatacac cggcggaatc cagcgccgtc actttctgcc ccagcattgt 2988241 gccgtccttt ctgtgataaa accaggagga ttgcagctgt ctttcgtgat attccctaat 2988301 attttcgatt gcctgcctaa tcacctgaag aagacgtgaa tccagtgagg tgtatgcctc 2988361 ctcaaattct tcttttgtga ccagcgggct gtctatttcg atgcagtcaa atttcgccgt 2988421 gtagctgcga accgcctgat caccgtttgc tttaacatct tcaataatgg accggaccgt 2988481 ctttctttgc tcttccgttc cggcatcgat ggaacgcttg agagaaagcc gttccgctcc 2988541 gctgatggtt ttgatcttca ttttgccgtc tctccttcca caacgagaga taggcgggat 2988601 gccatttcgt caatcacatc gtctttcatg cgatagctta ccgggttgac aataaagcga 2988661 gaggtaatgt cacaaatgtg ctccgtttca acaagcccat tttctttcag cgtctgtcct 2988721 gtggaaacaa tgtccactat ccgatctgca agcccaatga gcggagccag ttcaattgaa 2988781 ccgttgagct taataatctc gacttgttct ccctgctctc tgaaataact ggaagccaca 2988841 ttcggatact ttgtcgcgat tcttggcgct actccgctcc agtctgtatt cggaagtccg 2988901 gcgacagcta agtggcattt gctgatgttt aaatccagta cctcatacac atcgcgttcc 2988961 tcctccagca tgacatcctt gcccgcaatt ccgacgtctg ccacgccatg ctccacatac 2989021 gtggttacgt ccatcggctt cgctaatata aaccgaagat tttcctccgg cacatcgatg 2989081 atcagttttc tcgaatcttc aaactcctca gggagcctgt agcctgcctg cctcagcagc 2989141 cctgccgctt cttcaaatat ccggcccttt ggcatcgcca ttgtgagtaa cttacccatt 2989201 ttgctcttcc tttctggcac cgataaaata agtgacgttt gcaaaagatt ttgtcatctg 2989261 gtcgatattt tctattcccg ataaatcttg aagaaccact ttgttccctt tcatgcgttc 2989321 ttcattcgca taagcgatgg cttgcgcccg ctgctctttg ctgaaaataa cagcgtctat 2989381 ttcacaaggt tcgtccttca tatgaagggc ttcaatcagc cggtcgatcc gaagcccgaa 2989441 gcctgttgcc ggtgcaggtg aatcaaaatg gcccagcagc ttgttgtaac ggccgccgct 2989501 tccaatgaca aaaccgacat tctcggcgta cacttcaaat aaaatccctg tgtaatagct 2989561 catgtggctg accatattca gatccaggcg gacattttcc gtacatccgt aatcctcaag 2989621 aatgtcccac agcgccttca gctcatcaac cacgcttttt ccttgcgcag aatcgacgat 2989681 ttcctcggca cgtccgcata cttctatacc gccccgcagt tcaaggagct caagcagcct 2989741 gcttttatca atggaggaaa gcgggagaga cttgacatgc tctctgtagc cgacgtagtt 2989801 cttttcatat aagaacctcc gcagcacatc agctcgttca acgtttccga gcacctcaac 2989861 aaacaaagca tccgcaatgc cggcatggcc aattgcaatt ttaaaggatg ccagcccagc 2989921 gttttttaat gccccgacga ctaaagcaat gacctccgca tccgcgctcg tcgtgccgtc 2989981 accgattaac tccactccga cctgctcgaa ctcagccgga cgtccgcctt cacgctcctg 2990041 agccctgaat acatttgccg catagccgac tcttagcgga tgaccgtgtt tcagaagctt 2990101 cgatgccgcc acccttgcaa tcggccccgt catatccggg cgaagcacca atgtcttgcc 2990161 gtcctgatca agtagcttaa acagctgctg ctcttcaatt gctgactgga cgccaacggt 2990221 atcgtaaaac tccagtgtcg gcgtttccat aaattgatat ccccatttat caatcaaatc 2990281 ggttaacgat cgtctcacct tttttttcgt ttcgtataaa ccgggcagtg tatctctcat 2990341 gccgtgcggt ttttcaaaca taaacatcaa cccgagcacc tccgctgtta tcttatgaag 2990401 gaaaattccg aatcctttag ttcgctaata tgataatatg ttagcagatg aaagaatgaa 2990461 aatcaacgct taacttcagt aaggatattt ttagttcaaa tatccttctc ctcattatga 2990521 aaaaatcatg aataatgtat taaaggtacg taatatctca aattctttat gtttggcatg 2990581 ctataataca aatcaaatag agaacaagga gataaagatg aaaacactgc gaactctatg 2990641 tgtcctgatg attctttcag gcgttatttt tttcggactt aaaatagatg caaaagatat 2990701 agatattcct tttttgaaca gccttaaaaa agtggtttct gatagcgata cagactcagc 2990761 tgcgaatagc aaaaaggagc tgaagggaag cgcaaaaccg ctggatgtca tcctttacaa 2990821 tcaaatggac gcaccccggc tctataacgg ctgtgaagta acaagccttg cgatggtgct 2990881 gaattatgcg ggatacgacg tgacaaaaaa taccctggca aatcaggttg ccacagtgcc 2990941 tttgacatac agcagcggat taaagggtga tccgaatgac ggatttgtcg gggatatggc 2991001 gaatggccct ggtctcggtg tctaccatcg accgatctat cagctggcga aaacctatgc 2991061 gggagacaaa gtgtctgatc tgactggaaa aagtatttcc gctgtttatc agcagcttga 2991121 aaaaggcaat ccagtttggg ttattacgac agccaacttt acgccagttg acaacatgca 2991181 gacatggaaa acgccaaacg gaacgataga aattacgtac agcgaacaca gcgtcgccgt 2991241 tacgggatat gatgataaat atgtgtatct caatgatccg tatggctata aaaacagaaa 2991301 aaccgataga acaagctttg aaaaagcgtg gaaacaaatg ggcagccagg ccgtggttat 2991361 tcaaaagtaa acacctgaag cctcactatg ctctattctg agcaaatacg acaatattca 2991421 tgctttttgt atcaatcggt aagatcgatt cattttccat ttttcaccca aaattgtctt 2991481 tactttcagg ctgtctgttt ttatgattaa agcagattca gccttgcccc gatctatgcg 2991541 agagaagccg gtgcaagtcg ctgacgcttc tcttgcaaaa aatgaaagat atccggggag 2991601 gatttatcat tgaaaaaaat cgtgtctatc ctatttatgt tcggtttggt tatgggtttc 2991661 agccagtttc agccatcaac cgtttttgca gctgacaaag tggtgcacga aacaattatc 2991721 gtaccaaaaa atacaacata tgacgggaaa ggacagcggt ttgtggcagg gaaagaatta 2991781 ggtgacggaa gccagtcaga aaaccaagac cctgtttttc gtgtggagga tggagcaacc 2991841 ctgaaaaatg tggtgcttgg tgcacctgca gctgatggcg tgcacactta tggaaacgtt 2991901 aacattcaga atgtgaaatg ggaagatgtt ggtgaggatg cgttaacggt gaagaaggaa 2991961 ggaaaagtga cgatcgacgg cggttctgct caaaaagcgt cagataagat attccaaatc 2992021 aataaagcca gtaccttcac agtgaaaaat ttcacggcgg ataatggcgg gaagttcatt 2992081 agacagcttg gtggttcaac cttccacgtt gatgtgatca tcgacaagtg caccatcaca 2992141 aacatgaagg aagcgatatt ccggacggac agcaaaacaa gcacggtcag aatgacaaat 2992201 acacgctact ctaatgtcgg tcaaaaatgg attggtgttc agcatattta cgaaaacaac 2992261 aacactcaat tttaacaaaa aaagtccgct gatgttattc agcggacttt ttcaatcttt 2992321 cttgcatttc ttccttcgta tagatgatcc tcatcggatt tccgccgaca aatgccccgt 2992381 caggcacatc cttatggaca agcgttccgg cggacacaac tgcgccatct cctattttca 2992441 ccccgggcag aatggtcgtg ttggcaccaa tcatcacttc gtccccgatc agaactttgc 2992501 cgatccggta ttcgtgaatc aaatactcat gggccagaat ggtcgtattg tacccgatga 2992561 ttgtatttgt tccgactgag atcttttccg gaaacatgat atctggcatc accatgaggg 2992621 caaaggatgt ctgttttcca accttcatcc gcagaaatgt gcggtacagc cagtttttca 2992681 tccctataaa cggcgtatat ctcgcaattt gaatgacaat gaaatttttg acgaccttta 2992741 aaaaaggtac cgtttgatag acatgccaca gtgagttggc ccccgagacc ggatgacgat 2992801 ctgtttttct cacagattac ttcactccaa cgatttgtaa tagatcactc attttctcaa 2992861 gcataaaatc cggctcatgc ttcgccagca tttccggccc tttaatcgtc catgcgactc 2992921 ctgccgtttt tgtaccggcg tttttccctg ccagcacatc atggtaatta tcaccgacca 2992981 taatggcttc cgccggctcg cttcctagct gtttcagcgc taacagcaca ggctcgggat 2993041 caggctttgc attcgtcaca tcatcaaggg tgacaactgt ttcaaagaat tcgccgattc 2993101 ccgtgagctt gaggcccata ttgacagtat ctcttaattt tgttgtcaca attcctaatg 2993161 taaagccggc tttttttaat gcatccaggg tctcatatac cgtttcatat tcagtgacga 2993221 gtgaatcatg catgtcatga ttgtacgctc tgtacatagc gatcatatcc tcgcatttat 2993281 cagggtccat cgaagagaac gtatcaaaaa gagacggccc gataaatgca aggacatctt 2993341 ctcgtttata cttgctcgga taataatgct ccagtgtatg caaaaaggac gcgataatta 2993401 attcattcgt attaataagc gttccgtcta aatcaaacag aatcgtcgtt acttgtttgt 2993461 cactcatatt gcttcctttc caaccgctga gggtttccat tttttccacg tgtgcgcaat 2993521 agccattgtc agcagaactg ctgtggtgac acgaatcaaa agaagcggcc agaccggtat 2993581 gccaagcgga ataaagacaa gtgtatcttc cacgaccgcg tggcaggcaa cgagaaatat 2993641 aaatgccaat gtcatgtccc gcttgctcac gccgtcatcc tcgacagctt tgatcatgac 2993701 acccgctccg taggccagac caatcgtcag tcccgtcacc atcgtcatag acgtattttt 2993761 attcatgcca agcagctgcg taaacggcga cagccacctg gaaaaccgat aaagccagcc 2993821 taaatctctt aaaaactgga tgataatcat cagcgggatc actattgccg ccagctgcaa 2993881 aacaccaagt ccggctttcg ttaatgcttc tgccaacatt cctagccagc tgtctggcgc 2993941 cgcgctcttc gcagcgataa aaccgtactg cgccgtttcc tttccgccat gccaaatgag 2994001 gttgatgacg atggctgaca cagcggccaa accgatgcgc acggccaata tgacgccaat 2994061 tctgatacca acctttgcgg caactgtcga ttcgataatc aagttatgac agaaagaaag 2994121 cataacagct aaaataaaga cttctttcac agataaatcc aatgttaaaa tcccggcaat 2994181 tcccgcatac agattcagca tatttcccag tacaagcgga atggccgctt caccagaaag 2994241 cccgaagaga cccattaccg gtgtgatcag ccgtacaagc caatccatga caggggtatg 2994301 ctggagcaaa gtgaccaata gcgttaccgg gaaaatcact ttacccagcg tccatgttgt 2994361 ttgaaaacct gctgcaagac cggccagaaa gatcttcttc atccctcatc cccctttgtt 2994421 gacgtctact ccgcgtaccg ctccttcgag tatcccttga cgcgtctgaa gatgatggct 2994481 gccacagcca aaacaatcaa tacgattgaa atcacctgag cgatgcgaag tgaatcagtc 2994541 agcattaagc tgtcagtccg cattccttca ataaagtatc ttccgattga ataccaaatg 2994601 atatagatca agaacatctc gcctctacgc aaattcgctc tgcgcagcag cagtaaaaca 2994661 atgacgccga caaagctcca tagtgattca tataaaaaag taggatgata atattgccca 2994721 ttgatataca tttgattgat gataaattca ggcaggtgca ggttttctaa aaaggctctg 2994781 ctgacagcct cgccgtgcgc ttcctgattc atgaagttcc cccagcggcc gatcgcctgg 2994841 ccgagcaaaa tgctgggcgc ggcaatatcc gcaagcttcc agaacgaaag gtttttcact 2994901 ctcgaaaaca cataacccgt taaaatggcg ccgattaatc cgccatgaat ggcaatgccg 2994961 cccttccaaa tcttaatgat ttctcccgga tgtgccgcat aatagtccca ttcaaaggca 2995021 acataataaa ttcgtgcgca aataatcgca attggaatgg caaacaggac aagatcaata 2995081 aacgtatctt tctgcagccc ccgtttttca ctttccctca tcgctatcca cagcccgagc 2995141 aaagcgccga gaccgataat gattccgtac cagtggacgg ctaacggccc cagctgaaat 2995201 gctatcggat tgagtggttc tatcgcttca ttcatttaac gccaactcct attcttcttg 2995261 ttcaccgtct tcaatgacgt ccgccagctt gttggtaaat tgttcagcgg cattcagccc 2995321 catccgcttc aatctgaagt tcattgctgc cacttcgatg atgactgcaa gatttcggcc 2995381 tgggcggacg ggaatcgtca gttttgtaat ttctgtatca atgattttca tggtctcttc 2995441 ctcaagtccg agccggtcgt attgcttgcc ctgctcccag agttcaagat tcatgacaat 2995501 cgtgattcgt ttattgcttc tgaccgcgcc agcgccaaat agcgtcatca cattgataat 2995561 gccaaggccc ctgatctcaa gaaggtgctc aattaattcc ggagcgtttc ccacaagagt 2995621 atcctgatcc tcctgccgta tttcaacgca atcatcggca acaaggcgat gccctctttt 2995681 cacaagctct agcgctgttt cgctttttcc gacgccgctt tttcctgtga tcagcacgcc 2995741 gacaccatat atatcgacaa gaacgccatg aattgctgtg gtaggcgcca gcctgctctc 2995801 aaggaagttg gttaaacggc ttgacagtct tgtcgttttc agcggcgatc tgaggacagg 2995861 caccccattt ttctcggagg cgtcaatcag ctcctgcggg atgggcatat ctctagaaag 2995921 aataatagct ggtgttacat cagtgcacag agaatccatt cgctgctttt tctcctcttc 2995981 aggaagctgt tcaaagaaag aaagctctgt ttttccgaga agctgcacgc gctccctcgg 2996041 gtaatatgta aaatatccgg caatttcaat acctggtctt gataggtcac tcattgtaat 2996101 cgggcggtta attccttctt ctccgctgat taattccaaa ttgaactgtt ccattacgtc 2996161 ttttgtgcga acctttgcca cgatatgttc ctcctgttcc gggctgcccc gagcttgctc 2996221 acaatacttt cattttatca ctttcgggct tgaacctaaa acagatttta taaaaggggg 2996281 gaaaacacct cagctggtct agatcactag tctgaaaaag agtaaaataa aggtattcaa 2996341 attccagaaa ggcggatcat ctatggcaga gagtcttctt atcaaagaca ttgcgatcgt 2996401 gacagaaaat gaagtaatca aaaacggcta tgtcggaatc aatgacggaa aaatcagcac 2996461 agtttcaaca gaacggccca aggagccata ttcaaaagag attcaagcac ctgcggattc 2996521 cgttttgctt cccggcatga ttgacattca tatccacggc ggctatggcg cagatacaat 2996581 ggatgctagc ttttccacgc tcgacatcat gtcgtcaaga ctgcccgaag aaggcacgac 2996641 gagcttttta gccacaacga ttacccaaga gcatgggaac atttctcaag ctttggtgaa 2996701 cgcaagagag tggaaagcgg ctgaagagtc ctctttatta ggtgcagaac tgctcggcat 2996761 tcatttagag ggcccctttg tttcgcctaa aagagccgga gcgcagccaa aggagtggat 2996821 taggccttcg gatgttgagc ttttcaaaaa gtggcagcag gaggcgggcg gactgatcaa 2996881 aattgttaca cttgcgccgg aggaggatca gcattttgaa ctgatccgcc atttgaaaga 2996941 cgaatcgatt atcgcatcca tggggcacac ggatgccgat tccgcattgc tgtcggatgc 2997001 cgcaaaagca ggggcgagcc atatgactca tctgtacaac gcgatgagcc cgtttcatca 2997061 ccgagagccc ggagtgatcg gaacggcgct ggcccatgat gggtttgtga cagagcttat 2997121 cgccgatggc attcactccc atcctttagc tgcaaagctt gcttttttgg cgaaaggcag 2997181 cagcaagctc attttaatta ccgattccat gagggcaaaa ggactgaaag acggcgtata 2997241 tgagttcggc ggccaaagtg tgacggtaag aggacgaaca gcacttcttt cagacggaac 2997301 ccttgccggt tcgatcctca aaatgaacga aggcgcacgg catatgcgtg agtttacaaa 2997361 ttgctcttgg acggatatag ctaatataac ttctgaaaac gcggccaaac agctgggcat 2997421 ctttgaccga aaaggcagtg tgactgtggg aaaagatgca gatttggtga ttgtcagcag 2997481 tgattgcgag gtgattctca ccatttgccg cggaaacatt gcatttatat ccaaggaggc 2997541 tgaccagata tgaaagtaat ggaatgtcaa acgtatgaag agctaagcca aatagcagcc 2997601 agaataacgg cagatacaat caaagaaaaa cctgatgctg ttctcggttt agcgacgggc 2997661 ggcacaccgg aaggcacgta tcgccagctg atccgcctgc accaaactga gaatctctca 2997721 tttcaaaaca tcactacagt taatttggat gagtacgccg gactttcaag cgatgacccg 2997781 aacagctatc acttctatat gaacgaccgt ttttttcagc atatcgacag caagcctagc 2997841 cggcatttta ttccgaatgg aaatgcagac gatttggagg ccgaatgcag acggtatgaa 2997901 cagctagtcg attccctcgg cgacactgac attcagcttc tcggcatcgg ccgaaacgga 2997961 cacatcggct ttaacgaacc gggaacgtct ttcaagtcgc gaactcatgt tgtgacatta 2998021 aatgagcaaa cccgccaagc gaatgccaga tattttccct ccatagacag cgtgccgaaa 2998081 aaagcactga caatgggaat tcaaacgata ctctcaagca agcgcattct gctgcttatt 2998141 tctggaaaaa gcaaagcgga agctgttcgt aagctgttag aaggaaacat aagcgaagat 2998201 tttcccgcat ctgctttgca cctgcattcc gatgttacgg ttttgattga tcgtgaagcc 2998261 gcgtcattaa gaccttgaaa ggaacatgct gacttatgaa tatcaataaa caatcgccta 2998321 ttccgattta ctatcagatt atggagcaat taaaaaccca aattaagaac ggagagctgc 2998381 agccggatat gcctcttcct tctgagcgcg aatatgccga acaattcggg atcagccgga 2998441 tgacagttcg ccaggcgctt tctaatttag ttaatgaagg cttgctctat cgcctgaaag 2998501 ggcggggcac ctttgtcagc aagccaaaaa tggaacaagc acttcaaggg ctgacaagct 2998561 ttaccgagga tatgaaaagc cgcgggatga caccgggcag caggctcatt gattatcagc 2998621 ttattgattc aactgaggag ctcgcggcta tattaggctg cgggcacccc tcctctatcc 2998681 ataaaatcac tcgggtgcgg ctggcaaatg atattccgat ggcgattgag tcctcacata 2998741 ttccgtttga gcttgcgggt gaattgaacg aatcgcattt tcagtcgtcg atctatgatc 2998801 atattgaaag gtacaacagc ataccgattt cccgtgcaaa acaggagctt gagccaagcg 2998861 ctgccaccac ggaagaagcg aatattcttg gtattcaaaa gggagcgcct gtcctattaa 2998921 ttaaacgaac aacatatctg cagaacggaa ctgcttttga gcatgcaaaa tccgtataca 2998981 gaggcgaccg ttatacattt gtccactata tggatcgtct ttcataaaaa aagcctccaa 2999041 ccctttttaa ggattggaga catggcgaaa atcaaactgg tctggtgccg gacgatatgt 2999101 ttcttttttc gtcttgaact tccagatcgg tgatttcgtt ttgccgttaa aactgtcttc 2999161 cactataatg taccaataat aaacagactg cggttcaaga tgatcccagc ggaattcagc 2999221 tgtgtccccg ctcttcactt gctcccgttt tccgagctct tcattggtat atacgttaca 2999281 ttcaaaataa tcggtttcca cctttttgat tcttggcttc aaatcaagcg aaagggaaaa 2999341 ttcatccttg ttgccatagg tatccgtatc atagtagttc ttatccttta catacggaga 2999401 gtacgtcgat acgtgcacca tgtcattggc ttggtcaaat tgaagcaaac gcaaataccc 2999461 ttggccgcct tctggcccgc cctgataatc ggccagcatt tgatgcacaa gacgatccgg 2999521 tttcccatca ccatcatcat ccagctcatc tgtttttctc atcgcactat gataatgccc 2999581 gctcaacacc atcacgacat tcgggttcgg ctttacgatt tctttgaata ttttctctcc 2999641 gattgggctt ctgtttccgc tgaccagcaa atactcatga aaagctaaaa tggccatccg 2999701 gtcaggatgc ttcttcagca cctgattcat ccacgcgatg tcttcatccg taatgcccca 2999761 tcccatgtac agcatgatat aatcattgcc gttgctagaa atcaggtcat aatgtccgcg 2999821 gttattttta taggaaccgc cataatgaaa ttttttatca aaacgatcgc tgccaaaata 2999881 tttgccaaac gccctgtagg agccgtcctt atgtccgaca tcgtgattgc cggccagcac 2999941 gccgtaagga attccgctct tatccagaac ggacattgac cgatcagcgt ttttccactg 3000001 tctgatatcg gcggaatcat ctacaatatc acccgtgtgg aacacatatt tgatattgag 3000061 ctgcttttga ttatctttta tccattcggt ctgtttatca aaaatatgcg gatagctttc 3000121 ggcgtaatac tgtgtatcag acatccagac aaatgtgtac atatccttcg caggaggaat 3000181 ttcatcctgt acaatcacat tcattttcga ctcccgtaca aaatcggcgg caatcacaga 3000241 cgctttcagc gtaaacggtt tgtcatcctt cgcgacgaag ctgtcaacag gctgccattc 3000301 gtttgtccga taattccaag catacatcgt cacctttctc cccggcaaag aactgccctt 3000361 ccagactgat tctgccagat cattctcatc aattgatgga tcaaccgtca cttcaaagcg 3000421 atgataaggg aaaagctctt tgttttctgt cgatactgtt tttccatcag cagctgatac 3000481 ccgctccaat tctttattcg taaatggggt ctccctttcc ggcacaaagc ttttcggcgg 3000541 ttcagtcagt gacgcgtgct taaatatttt cacatgattg cgcgctgtat attgaaatcc 3000601 cctataaaaa ccaacatcca tggcatcatt cgtcggatct ttcacccgta cagaaagctt 3000661 ggccttatgc gtgtcggctt cgctgtctat aacctccggc tggtccggat gctctcgttc 3000721 ggttttaaat atcctctcaa tcactgtttt attgcccgcg agatccgttg ctgtcacttt 3000781 tagagaatgt tttcccggca aaaggtcaga agatgacgta tgatatggga gtgtaatgct 3000841 ttctccatct aacgacgcct ccgcttcctc aattctgctc catttatcat acatatccgc 3000901 ctgcaggata aggtttcctt tatacgtttg cccctcggtg atattcggct caatgtgagg 3000961 tcctgaatta tctacccgta caaccaggct gacattttcc ttcccgtcgc ttgcttgaat 3001021 atggtgagcg ccttcagaaa gctttgatgt atcccactcc agcagctgtg atgtaaatag 3001081 tccgtcaggc agattgaact gaaattgcca gcttttattc gagcgctgat tatcgccaat 3001141 aaagagttcc ttctcaggag acaccctctg atctctgatc accgttccat ccgataacac 3001201 caatcgggcg tttttgacta agaagtcatc acggttttca gccgtatcaa acggagacac 3001261 cttcgaacct gaacgtatcg taatacgctg cagctgcttc cctttccgaa gcagtgtctc 3001321 tggcaatgga acagaatagg tgcggtattt atttgttgta tcatcgaaca ccttcagcac 3001381 tttgccttcc atcgttaccg cgtttttaaa ataaaggttc gttttcctcg tatcgaatgc 3001441 aaaatatact tctttttcca tcgcgggctc tgtcacttgt tttttcccgt caatccatag 3001501 cttaatgctg tcagctcgcc cttctgtcgt ggctttgaga aattgagttc ccgacagcgt 3001561 gtctctgttt tcaatattca tccgcagacc gtgcgccttg cttgtttgtt taatatcaat 3001621 cattttgacc ggcgttctcg cttcattgat cccgtccccg gccgccacat aatactctag 3001681 ctgatccttc ccgatcaatt caggcgaata cacaatataa tggaagagat tatcgttgcg 3001741 gtctttttca gcaagaattc gcttaaacgg tttgttctca tccgtccggt agtaaaaggc 3001801 cactgttttc actaggcttc ggtcccgtat gtcagcccgc agctcaatgc tttcagcagg 3001861 gcggacaggc ttgcggtcag tcaaatcctc aatgaccggc ttttctttat cgagcttgat 3001921 tttccgtttc tggtcgggca cctgtgcctg taatacggtt ccgggagacg gattcttttc 3001981 cccgattgaa atgttcagaa gttctgctgt tccgttcagt ggatacttat aaagcactga 3002041 tgacagccgg cgcagcgcat gtttccgata atgcgcaacc gaaatgtcct ttcctgtatt 3002101 cgttgatatc acaacggccc gcggcctcgt attggccata ccctctgtct cgtctatcac 3002161 cgcaagattt tttccttctt ttagttgtgt ctgataataa cgattgaaat ccgctgacgt 3002221 caattctgga tgcccggcag gcttcagcca gacgacaaac gtttcgccgg atggtatcaa 3002281 gatcctttca tcaggtctcc aaatcagatc ggagtcaggc ccttcttttg ggtagcggta 3002341 acggatatgg tagtctttaa aatcaatcgt tctgtcagtc gtattaaaaa tctcaataaa 3002401 ttcataaccg tctgcgcgtc ctatattctt cgtatcaacc gccagctctg tgatcagaag 3002461 ctccggaata tgggcaaggt cagcctggta tccttcaagc ttcagtttct tcgtctccga 3002521 ctcaacccgc tgcttcccat tcgacatcac aatgtaatac tcaagctcgc tgttccaaat 3002581 caaacgtttc ggaatttgtg ccaaaaactt gcggaccgct ccgggggtcg ggtccatcgg 3002641 caccattttg tagcccagct cattactttg tttataaaaa agaaaggcgg aaaatgcttg 3002701 atacgaatta tcgcgaactt gagcctcaat cattagattg cttctcattt cagctttcac 3002761 atcaatttga ggaggatttt caagcaaggg tatgtaatga ggcgtttgaa atagttcctg 3002821 ctgtacaaca ggaaaagctt tcgattcatg atggccgcca gacaaaacgg aaagaaaaga 3002881 cagtaatata gaagcaataa ccgtgtattt cctcatcaaa gcacctccct tttcatgtat 3002941 tttgcgtctg aacagggaag cttatgagtt catttttgtg cataaagaac aaaaaaacgt 3003001 ctgtctcttg aaaattccac tattacccag taaactaagg atagttaacc agttaacaat 3003061 taaatcagag aggcaaattg atggacaaca gcattcatga tgaattattt caagctatac 3003121 aacaattcgc attaaaaagg gataaacgcg tctggcaaaa ggtgcagata ccatccattg 3003181 gcatatcctc acaacatcac gatcacctca aaaaagactg gactttgacc cagcttcaca 3003241 ttgtttcctg catacatacc agccaaaatg tgaacaacag cttcttagca tcccgtttac 3003301 acatctcaaa agccgctgtt tcaaaagcgg ttcatgcttt gttgaaacac aatatcatta 3003361 cagtgacaaa aaagcctggc aacaaaaaag aaatttttta tacgctaact gatagcggca 3003421 gaaaattggc ggcattacat gaacagcttc atgagaaagc aaaggagcaa tataaacagc 3003481 ttttcaatga attttcaatt gatgatttaa aaacagtgac tgcgtttttc aacttgtgga 3003541 tcaaatatat gtaaaaagag tctcacccgc atgggagaga cctttggaat tctattatgc 3003601 cccgtcaaac gcaacgagaa gtgaaacagg tccgcgtgta tacagaccgg actcagcata 3003661 acaaaaatct tcctctaatc tgatattccg catcttatcc agcacaatat tagctacaat 3003721 ttcgatttcg tttttggcaa aagctgctcc tacacagtta tgaatgccgg atccgaaagc 3003781 gagatgccgg gcggcgccgc taaaagcgct cttgatacca agatcttccc gatgaatatt 3003841 aaacacgtca ggctgttcaa atgcttcagg gtcccggtta gccgcaccga tcatacaaaa 3003901 aacaatcgta tcttttttga tttccatacc gccgaccact gtatcttggg acagctgccg 3003961 cggaatcagc tgaaccggcg gtttataacg caatgtctcc gcaatggctc tcggaactaa 3004021 cgaacggtca gccaaaacat cattcatctg ctcaggattg ttgagcaaat ggtagatcat 3004081 cagtgccagc gtcttatcag ccggttccgt tgcggctaac agcacattaa gaatcagtgc 3004141 gagtatatcc ttgtccgaca gcgccatgcc ttcatattca gaagtacata ggatcgaaat 3004201 taaatctgat cccggattga cgcgacgttc tttaatgacc ggcatcaagt attgggaaag 3004261 ctgttcgctg caccataacg aatgtgcccg cgcttcagga gattgagaga tactcgtgat 3004321 aaaatcggca actccgctgt gccactcaga gattttttca tggtctcttt tatccagccc 3004381 gagcatgtcc atcgtgacgc acaccgcaaa cgtctttcca aaatcattga cgagatcact 3004441 tttccctctt tcaagataag gcgctaacaa gttttctgca ttttgtttaa tcaatggaga 3004501 cagatgatcc agtgcgtcac cgataaagct tctcactaca attcttcttt tggcagagtg 3004561 ttcttttcca tgcatttggg ccagcacagg gcctcgcatg actggttcgg cacgctcaac 3004621 aagtgatttc gtcgtgaaga tatccggatg ctgaaggata tagcggacat catgatagcg 3004681 gctgataaaa taactgtcta tcgactcttc ataatgaacc ggatcttcct cccgcagttg 3004741 tgaaaaataa gcatatggat tgttttgaaa ttgatcagaa agcacactaa acaatttaat 3004801 cgattggctc atgttttact ccccctatca tccttcagat gtgatccgtt tctcagaaag 3004861 catctgcgcc atttcctgta caatgagata cccttgattc ggccgcatac aaatagaaaa 3004921 ttcatggtta ctgatcttct cacccagctt ccacggacga tgataagcaa ggagtgtctc 3004981 ttccacctct aaaatatccg gagctccgat aaaaaacggc agctcagcta tgacatattc 3005041 cacagccaaa ttcagcatat cctcactgac ttcttccatc atcaaactga cgccccgcgc 3005101 acgcccgatt atcgcttcac gagacatgtc caaacaagca tgtcgaaaat gaggctgctc 3005161 aaaaaatgca tgttcaactt cttgtctcaa cagctggtag gctttgttat ctataaaatc 3005221 agaaaatgta tgaatcgcct tcggatcccc gccatgagcc acaagggctc tttctgcaaa 3005281 tctcctgttt cgtgatacct ctttccttac ttttcgttca gcctttcctc tcggagttcc 3005341 aagcgcttct agaagattag ccgcctcatg ccctgcaagt aaaactgaaa cgcttttaaa 3005401 ttgagctttc gcccatccaa ttaatctgta aatataatcc tctgaaaacc tgctgttaaa 3005461 tgggctgatc cccaccaaaa catgcctgcg ccgttcaaat atttctctgc agttttctgt 3005521 taatgcctca gcaataaaat gcacagacct tctttccgtt accattccgg tcatctcatt 3005581 cacccctaaa acttatcccg ctttaagtca tcaccctcaa atacaagatg gaatagctag 3005641 aacaactgaa caagacgaat ggcaggcatc acttaaagtt tccaaatgtt ttttaagatt 3005701 ttaataatca ttttcaatac ccatatcatg ataaatgttt actagtaaac attagtcatt 3005761 ttatcccttt tccttccaaa cgtcaatatg atctgtgccc aaatatttga aaataaatgt 3005821 aaacatcaca ttttccacac actttttaca cgcatattca gcatgacata tcaacaaata 3005881 gtctaaacac caacaattga caacgaaaac aagaaaagat aaaataaaat tgttcaccag 3005941 taaacgattt gttttattgt ttcatcgtaa actattattc ctaagaaaga aggtagccta 3006001 tgtctgattt gacaaaacag atgatatacg acatatacgt gagactgctg caccttaatg 3006061 aacaaaaagc gaacacttca cttcagcaat tttttaagga ggccgcagaa gaggatgtag 3006121 ctgaaattcc caaaaatatg acaagcattc acgtcattga ctgcatcggc cagcatgaac 3006181 ccattaataa tgccggaatt gccagaaaaa tgaacttatc gaaagcgaat gtaacgaaaa 3006241 tcagcacaaa actgatcaag gaagaattca ttaacagcta tcagctgaca gataacaaaa 3006301 aagaagttta ttttaaatta acccgtaaag gcagacggat tttcgactta catgagaaac 3006361 tgcataaaaa aaaggagctg gctttttacc aattcctcga ttcattttca caagaagaac 3006421 aaaaggctgt attgaagttt ctagagcagt tgacgtcaac acttgaagca gaacaaaccg 3006481 atgggactcc agacaaacct gtaaagtaaa caaaaaggcg gtgtacactt tggctcatac 3006541 aaaatcaaag gcagtattga tcttatacac tgtttgcttc agtgcatttt ttgcatcttt 3006601 aagccagaac atttattcac ctattcttcc gatcattaaa gaatcattcc atgtttccac 3006661 agctatggtg aacctgtcag tctcagtttt tatgattgtg acagcaataa tgcaaattat 3006721 attaggagcg atcattgatt ttaaaggcgc tcggatcgtc ttgattaccg gtattctggc 3006781 aacggcagca gccagcatcg gctgtgcggt gactactgac tttaccttgt ttctgatatt 3006841 cagaatgata caggcagccg gttccgcagc actgcctctt attgctgcca caacgatcgg 3006901 acagctgttt acaggaaatg aacgcgggag tgcaatggga acgtatcaaa tgctcctgtc 3006961 tgtcgcaccg gctattgctc cagttctagg aggattcata ggcggagcag ccggatacga 3007021 agggattttt tggatacttg cggccatctc tatcgttttg ctggtgacaa acagcatcac 3007081 ctttcctaaa gattctccaa ctgaatctat gcagcaagcc aaaggcaatg tgttcgctca 3007141 ttataaatca atatttacaa atcgaacagg gaacgtcatt ttgactttaa gttttgttct 3007201 ctttttcatt tattttgcag taattgtcta cctcccaata ttgctgacag agcattacca 3007261 tatagatgtg ggtatagcag gactgttata tttgccgctg gcgctgagca cgattgcagg 3007321 tacgtttctg tttaaaagaa tacaggcaaa aatcgggctg cacaccttgt ttatcggaag 3007381 caatgtgatt gccgcctgca gcatcatttt atttgctgtt acacattccg tttctctcgt 3007441 tctcatggct ctgacgctgg cactgtttgg catctcgatg ggggttattc ctcccttgta 3007501 ctctacaatg attactaatg aatttgagca caacagaggg agtgcaatcg gaatgtttaa 3007561 ctttatccga tatacaggca tggcagcagg tccgatggta tctgcctact tgctcacaat 3007621 gatgccgtct gccatgtcct ttagcctcct aggccttgga tttgccgcat tgagcttttg 3007681 ccttcttccg ccaatgtttt cgccgcagaa gcgcacgaaa caaaaaaagc accacatgta 3007741 aaaaagctgc ctttgcgggc agcttttttt atttttttct aagcggctct aaaatgcctt 3007801 tttgaatcag caaatggaag accgacagga taacggatgc ccatatcgct gtgccgaagc 3007861 cgtcgatttg aaagctgtca cccataatgg acgcggtcat cataagcgtg atggcgttaa 3007921 tcacaaacaa gaagagtcca agcgtcacca tggtgaccgg cagtgtaaat ataattaaaa 3007981 gcggtttaat cagcacgttt aagatcgata aaatgaggct ggcgataatc gctgccccaa 3008041 tgctgctgat atggatggag tcaatatatc catcaatgac gattaataac aatgcattga 3008101 ctaaaatgct gactgcccat tttaccatgt catttcatat ccctttctga cgggacgata 3008161 aaaatccaaa tgatataaat gagcaaaacc ggcaagacac ttgtcataat ggctaagatg 3008221 acagttatga ctctgaggag tgatgcgtcc caattgaaat attccgcgag acctccgata 3008281 acaccggcga ttttcttatt tttttctgag cgataaagct tattcattcg atcacctctg 3008341 tgagtacttt agtttgatgg cgcctgttag tgattctgag aagacggtga tgttttgatc 3008401 atgtgcctga tttgaagtga acatcatttc tttttgaatc gtatcatttt tttccttcag 3008461 catctctaca tccattaatt catgggacag cgtaccaaga ttgcttttca gctctgcctt 3008521 cactgcgaga tcgtccggaa ttgcaagctc tacatttcca gtcgttgttt ttgcataaat 3008581 ggagcggcag tctgattctg ttacgttaat cgcaatattt ccgttaaagc tttgaacgtc 3008641 aatggattcg cttttccctc ggagatcgat caatccgtta atggtttccg cttctatcgt 3008701 accgcagctg tggcttgcga gcttaatttg cccgttggcc gtttcagcta tggctttttc 3008761 ggctgttaaa tacgagaacg acagcacgcc gtttgtcgtt ttcgctgaga actcttttac 3008821 atgtaaatgt tcccctctga ctggaccgtt aaacagcttc acccgaatct tatcatactc 3008881 cttctgagga atatacaaag tgacattcgt tttcatcgtc tttttctcag tacggataaa 3008941 aaacttatta cctttgattt cacattcaat atgctgaaga aatgcgtgtc tcgccgcatc 3009001 ctggctgtca gcgcgatata ccttcgcctg gcattccgct ctgatatcgt catcttccca 3009061 agggacgata tttacgctgc cattggcaat ttgcagctca acactggaaa agtcagtatc 3009121 tttaaattga aaaatgtgct gaacatcata cgcatggcca aagtttaaat caaggtcaac 3009181 ttccttgacc tttttcacag cagaatcaat ccagtcaaac agcttggctc ctaaagacgg 3009241 tttgccgctt tctttttttg ccgttgtaaa tggctcttcc tcgtcatgaa cgtgaactga 3009301 gagcgctgtg attttctctt ctttttcctt gtagtcgctg tcaagctttt caatcagtgt 3009361 caaagcttct tgtgctgtaa gctttccttc ctcaacaagc ttaaggattc gttccttttc 3009421 ttgcttcatt acgatctcct ccccattgtc tacttatgct gcacgcagga ccttaatgcc 3009481 ctgaatcaca ttccaaatga taatgccaat gacaactaag aaataaataa ccgctccccc 3009541 gatgattaca aatacaggaa gcaagctgtc tccatcaatc gcaacggctc cgccaagtaa 3009601 agcaataaaa aggaacagcc agccgacaaa cggaacaatg tgagaaataa gagagcgtat 3009661 cgcatggcgt tttgtttctt tctcatttac aacaaaatat gcgacaatcg gcacaatgat 3009721 tggcgcaatg aacacactga aataacaaag tgatgcaata atagcttgat tacggttcaa 3009781 ttcattccac actcctattg tgaattgtcc atgacaaaag atcagggacg ttttacttat 3009841 ttatacgttt aaaatctctt caggtttcaa attcattctt tagacatgct ccgatttacg 3009901 gaaattggat tttaaaaagt tttagaagta gaatcttccg gctataccga ttacaatatg 3009961 taaaaagctt acggcaacca aggaggctgg acaagcaatg gagaaagatc ccagtgacta 3010021 tacagtaaca caagaatcag tgttaaagct gattcaggaa caaaaaagaa tgaatcgtga 3010081 aatgatcacc gagcttgagc agattcacgg acccttcccg atctctcacg atatccaata 3010141 tataaaagtg ctgctcgaca gcagcaacac acatattgtt caagatttaa tgagtgtaag 3010201 taagcagctg tataagaaga ctttgtaatt gcggaaaaca tatcattcat tataactgaa 3010261 acaaagctaa aggttagatg acaatatctt gccttttttg ttttgaaaaa acaagtgatt 3010321 ccctggctgt cacaaaatga ttgtaacaaa aaaagcctgc cggcacatcc agttaatgga 3010381 ctctgtcggc aagctgtaac tatcagaaag agatagccgt tcaaaattaa cgtaacaatt 3010441 gaagcacgtt ttgcggctgt tggtttgctt gagcaagcat cgcttgagaa gcttgagaag 3010501 gaatgttgtt ctttgtgaac tcgctcattt ctttcgccat gtcaacgtca cggatacggg 3010561 actcagcagc tgtcaggttt tcagaagaag caccaaggtt gttgattgtg tgctctagac 3010621 ggttttgtac cgcaccaagt ttagcacgtt ggtttgagac attgttgatt gcagtatcaa 3010681 tactttcaag ttgtgtatca aaaggagtat tagcaaaatc tgttacatta agtgcgttta 3010741 ctcctaaagc agttgatgac atgctgtcaa tgttaactgt aagctgctgg ccagcatttg 3010801 ctccaatttg gaaagtgaaa ccatcagttt cagtaccatc taataacttt ttgccgttga 3010861 attcagtacg atttgaaatg ccatcaactt cctcaataag cgcatccatt tcatctttaa 3010921 ttgcaccaag atcttctgct tgttgtgtac ctgtgtttcc tgcttgaaca gtaagttcac 3010981 ttctaaacct attatgccgt aaagaaaaag cttgcctgct aagcccaagg atggacttgc 3011041 cgacaagctg tcccctctta acagagggtt ttaagatgta gctgtttctt ttgctttcaa 3011101 gagcgatttc atgcgtgttt tgtcacgttc gataacaggc tttaaataac ggcctgtata 3011161 cgattcttca acttcagtga tttcctcagg cgttccagac gcgacaatgg ttccgcctcc 3011221 ggctccgcct tccgggccca aatccacaat gtaatcggcc gtcttaatga tatcaagatt 3011281 gtgctcaata accagtacag tgtctccgtt gtctaccaac cgttgcagca cgacaagaag 3011341 cctggcgata tcgtcgacat gcaaacctgt cgtcggctca tctaaaatgt agagcgtacg 3011401 tccggttgag cgtttgtgca gctctgacgc gagcttcacg cgctgcgctt ctccgcctga 3011461 caaggtcgtc gccggctggc cgagcgtaat ataacctaaa ccaacatcat aaagggtttg 3011521 gagcttgcgt ttgattttcg ggatattttc aaagaaagaa agagcatctt caaccgtcat 3011581 atcaagcaca tcagagatgc tttttccttt gtacgtcact tcaagcgttt cacggttata 3011641 gcgtttgccg tgacacacct cgcatggaac gtatacgtca ggaaggaagt gcatttcaat 3011701 tttaataatc ccgtctccgc ggcaggcttc acatcgtccg cccttcacgt tgaagctgaa 3011761 acggcctttt ttatagccgc ggaccttcgc ttcatttgtc tgcgcgaata catcacgaat 3011821 gtcatcaaat acaccggtgt atgtcgcagg gttggatctc ggcgttcttc cgattggcgc 3011881 ctggtcaatg tcaatgactt tatctaaatg atccaaacct ttaatctctt tatggctgcc 3011941 gggcttcgct ttcgctttat gaagcttttg cgccagcgcc ttatgcaaaa tttcattaac 3012001 gagtgtactc tttcctgaac cggaaacacc tgtaactgct gtaaacgtcc caagcgggaa 3012061 cttggcattc acttttttca ggttgttttc tgatgcacct ttaatttcaa tgtaacgtcc 3012121 gtccggcttt cttctttcag gaggcaatgg gataaacttt ttccctgata aatagctgcc 3012181 cgttaatgaa tttggatctt ccatcacttc ttccggcgta cccgcagata tcacctgtcc 3012241 gccgtgaatg ccggctcccg gtccaatatc tattaaataa tctgctgcca tcatcgtgtc 3012301 ctcatcatgt tcgacaacaa tcagcgtgtt cccgaggtct ctcatatttt tcagagcgct 3012361 gatcaagcgg tcgttatcac gctgatgcag accgatagac ggctcatcta aaatataaag 3012421 cacaccggat aaacgcgagc caatttgagt cgccagcctg atgcgctgcg cctctcctcc 3012481 ggacaatgta cccgctgccc tgctcaatgt caggtaatcg aggccgactt tgtccagaaa 3012541 gcttaagcgc tccacaattt cgcgcaaaat caaattggcg atctgcatat ccttctcaga 3012601 aagggtaaga tctttaaaga aggcaagtgc gtcggcgaca gacagctcgg taattttccc 3012661 aatgtggcgg ccgtcaatca gtacggcaag cgcctctttc tttaaccgat agcctttgca 3012721 cgtcggacaa gacttctgag acatatactg ctccatttgc tcacgtatga aatcggagcc 3012781 tgtctcctta tagcgtcttt caatgttgcg caatacgcct tcaaattgaa tttcaccttc 3012841 gcggatttgt ccaaaatcat tttcatatcg gaaataaatc aggtcatccc cgctgccgta 3012901 cagcacttta tccagttgat gcttcggcaa atctttgacc ggcacatcca tatcaatccc 3012961 gtagtgggtg cagactgcct caagcagctg aggataatat tgtgagctga tcggtgtcca 3013021 aggggcgacc gcattctcct tcaatgacaa atcttgattg gggatgacaa gatcggcatc 3013081 cacttcaagc ttcattccga gaccgtcaca cgtcggacac gccccgaacg gactgttaaa 3013141 cgaaaacaga cgcggctcaa gctcaccaat tgaaaatccg cagtgcggac aggcatgatg 3013201 ctcgctgaac atcagctctt cctcaccgat gacatcgatc ataacccgtc cttcacctaa 3013261 acgaagcgcc gtttccaatg aatctgacag ccgggctgcc acgccttctt tcacgacaat 3013321 ccggtcaatg actacctcaa tggaatgctt cttgttcttt tctaattcga tatcgtcgga 3013381 aagctcagcc atctcgccgt caattctgac tctgacatag ccttgtttcc taatctgttc 3013441 aagcactttg acatgagcgc cttttcggcc cgagacaatc ggcgccagca cctgaagctt 3013501 cgtccgttcc gggtattcca gaattctgtc caccatttgc tcgatggtct gggatgtaat 3013561 ctcaattccg tgttccggac aatgaggctt ccctactctc gcatataaaa gacgcagata 3013621 atcataaatc tcagttaccg taccgacagt agacctcgga ttgcggctcg ttgttttctg 3013681 atcaatgctg atggcgggag agagcccctc aattgcatcc acatccggct tatccatttg 3013741 ccctaaaaac tggcgggcat aggcagacag cgactcgaca taccgtctct gtccttcagc 3013801 atatatcgtg tcaaaggcaa gggaggattt acctgatccg gacaaacccg tgacaacgac 3013861 aagctgatct ctcggaatcg ttacatctat atttttcagg ttatgcgccc tggctccctt 3013921 cacctctatc cgatccatag ccatttgttc atcatccttc cgcttttagc tctaaaagta 3013981 aatcgcgaag ctccgcggct ctctcaaagt caagcgcctt ggcggcttcc ttcatttcat 3014041 gctccatctg ttcaacgact ttctggcgtt ctttcttcgt cattttcgac agcttcggcg 3014101 cggcttttgt tttgtattcc gctttatcct cagctgctac tgtggcacga atgacatcgc 3014161 gaatttcttt atttatcgtt ttcggcgtaa tgccgtgctc ttcgttaaac cgctcctgct 3014221 gctcgcggcg gcgttttgtt tcattaatcg caatttccat agacttcgtt attttatcgg 3014281 cgtacataat gacgcggcct tccgcatttc tcgctgcccg tccgatggtc tggatcagcg 3014341 accgctccga acgaaggaaa ccttccttat ccgcatccaa aatcgcaaca agggatactt 3014401 cgggaatgtc caaaccttcc ctcagcaggt tgatgccgac aagcacatcg tacttgccaa 3014461 ggcgcaggtc gcggataatt tcaatccgtt caagcgtctt gatctcagaa tgcagatagt 3014521 ttactttaat gccgatttcc tttaaataat cggtcagatc ctctgacatc ttcttcgtca 3014581 aagttgtcac aagcacccgt tcattccgct cgattcttgc ttgaatttcg ccgatcaagt 3014641 cgtcaatctg accttcgatt ggacggacgt caataagcgg gtcaagaagc cccgtcggac 3014701 gaatgatctg ttcgaccatt tcatctgtat gttcaatctc gtacggccct ggtgttgctg 3014761 atacatacac gatattgtgc atatgctttt caaattcctc aaaacgaagc ggacggttat 3014821 caagcgctga tggaagccgg aagccgtgat ccacgagcac ctgtttccgc gcctggtctc 3014881 cgttaaacat gccgcgcacc tgaggaattg tcacatgcga ctcatccacc acgatcataa 3014941 aatcgtctgg gaaataatca agaagcgtat acggcgttga acctggaggc cgcagagtca 3015001 aatgtcttga atagttctcg atgccggagc agaaacccat ttcacgcatc atttcaagat 3015061 catatcttgt ccgctgctct aaacgctgcg cttcaaggag ctttccgttt tcatgcatga 3015121 ccttcagctg ctcctcaagc tccttctcga tattttgaat cgccttctcc attttctcgg 3015181 cccgcgttac gaagtgggat gccgggaaaa tcgcaacatg atctcggtcg ccgagaattt 3015241 ctcctgtcag cgcatctact tcccgaatcc gttcgatttc gtcaccgaaa aattcaactc 3015301 tgacacaatg ctcatcacgg gatgccggaa agatttccac tacatccccg cgcacacgaa 3015361 atgtaccgcg ctgaaagtcg atatcgttgc gggcatattg gatgtctaca agttttctga 3015421 gcagctcgtt gcgctcaatt tccatttcag tccgcagtga cacgaccatt tcccggtatt 3015481 cctcaggcga accgaggccg tatatacaag acacactcgc aataataatg acatctctgc 3015541 gctcaaacaa agctgatgtg gcggagtgtc tcagtttatc aatttcatca ttaatactag 3015601 cgtctttctc tataaatgta tccgtttgag gcacatacgc ctccggctga taataatcat 3015661 agtagctgac aaaatactcg acagcattgt tcggaaaaaa ttccttgaac tcactgtaaa 3015721 gctgtccagc aagggttttg ttatgggcaa tcacgagagt cggcttattg acttctttaa 3015781 tcaaattgga caccgtaaat gttttcccag ttcctgttgc acccagcaga gtctgatgct 3015841 tcttgccctc ctgaattcct ttcacaagct tttcaatggc tttcggctga tctccctggg 3015901 gctgatattt cgagactaac tcaaagcgat ctttcacaaa aataagcctc cgtttcttta 3015961 acgaaatctt cctatagata tagtaacaca atggaaagca aaatcactaa aaatacgaac 3016021 taaagttcgg tggtttttta tttccagctg tttttgtgta taaaaaacct gcttttaaaa 3016081 cgtaaaagca ggtattcagt ctttatattc attatgtccg atttattctt cttttttctc 3016141 tgcagctttt ttggccatat acagtccgcc agccacaaga gacacaacat ccaatcctac 3016201 aataaaatac gtttctgtat agccttttaa ataagaggca aacagcaatg cagctgttaa 3016261 agcgatcgcc acataatgat taaaggtgac tctagtaaat agaacaacaa gcataaaagg 3016321 gaaaaacaat gcaaaaacgg cttttgtaat caacaaaaac cctcctcagg gattcttcat 3016381 ctgatctgat tatagtaaaa aatgaagaat cggacaatcg tgcattcgct ccctctactt 3016441 acaccatacc ccttttcagc caaaatcaat caccatattt gcattttggt gccggtcaaa 3016501 acttattcca tggtgccgct gttctaatca gcggcacttt ttttattaca tcatcaagtc 3016561 cgccgccaga ttccgagaat aaaagaaaat aggcatacag taccagtacg gccgcatttt 3016621 tcaggataat ataaccaact taactattca ttttatttag gactttctgc gtttgacagc 3016681 attttcctga aaacctacaa ttaaatgata gtgtttacta tcatttttta aacacaggct 3016741 ccgcaataaa aagactagag agaaaaacaa aatgaatgaa gaaaagaggg gtttcaaata 3016801 tgtattctgt tttatttcgc caggcagaag agtccagcca gctggctgga gcaaaaggaa 3016861 tgaatttgat taaattgacc aaacacggtc ttcctgttcc ggacgggttt attattcaaa 3016921 cgaatgcgct cgcacgtttt atggaggaca accagcttca agagactagt gaaaacgtcg 3016981 aaggcgggat catttccgga acattttcgg atgagctgaa agatgagctg actagttcct 3017041 tttataagct tagagaatca tatcgatccg tagccgtgcg ttcttcgtct gcttcggaag 3017101 atttagaagg cgcctcattc gcgggtcaat atgaaaccta cttaaatatc aaaacagagg 3017161 aagagtttct ggctaaagtg aaagaatgct gggcctcatt tttttctggg cgggtcagca 3017221 gctataagaa aaaaatgaac aatcaaatcg cagagccgtt aatgggaata gtcgttcagg 3017281 ggctgatcga ttcagaaatg tcaggtgtta tcttcagccg caaccctgtt acccatgatg 3017341 atagagagct tttaatcagc gccagctacg ggttgggtga agctgttgtt tcaggaaatg 3017401 ttaccccaga cacgttcatt gttaataaat cttcgtttga gattcagaaa gaaataggtg 3017461 caaaggaaat ctacatggag tctgcggcag aaggaattgc tgaaaaagaa acgagtgaag 3017521 acatgcgcag ccgtttttgc cttacagatg aacaagtgat tgaattggct gaaatcacaa 3017581 aaaaaaccga agacctgtac ggatatcctg ttgatataga atttggaatt gctgatcatc 3017641 aaatatacct tctgcaagct cgcccgatta caaccattga tcaggacaaa aaagcggcag 3017701 aagaaaaacg cagcttcatg attaccgaca ctgatatgaa tgatttctgg cttaacatgg 3017761 agtctaatat tgaaggtccg gtgagtccgt tattttcatc cttcatcgtg ccggcattgg 3017821 aatatggctt gaagaagagc atgcaaaagt ttccgattgg tgtagttgtt gatgaagtaa 3017881 aactttatcg cggacatatt tattccaaaa accaaggcgg acagcagcct ccttctgaag 3017941 actgcggcaa agagcttttc ccgattttat cggagcatat gtatgacatc atcaatcaca 3018001 catacctccc tttttaccgg acactggacc agctcgcaca aactgagcat accgcagaaa 3018061 gcgcactgga agcttttcaa aaactaaagg ccttttatct cacggcttat gaagagcact 3018121 ttaatatcgt tttcccgcaa atccttttaa caaacaaact gcaagcgatg tatcaggaca 3018181 ttcaaggaga gtccgaaaac gctcattttt acgagatgct gacaggaaaa atgaacaaat 3018241 cactggaaac ggaccgttgc ttatggctat tttctgtgga agttcaggag aacccgaacc 3018301 ttctggccat ttttgaaaac aacaagcctg aacagctcca ggagaaattg gaacaaacag 3018361 atgagggaag acacttcctg aagaacgtcc atgaattctt gcaagaatac ggatggagat 3018421 ctgttaaaag tcatgatctg attgaacaaa tctgggtgga aaatccgtat ttcgctctgg 3018481 ccaatattca aaattatgtc cgtaatggct atcattttga caatgaattt cagaaaacaa 3018541 aagaaaaacg agagaaatta tacaatgaat tcttggaaag catagaagat cccggtttac 3018601 gcaccgaatt tgaccgctat tatcaatgga cactgaactc tgcaaatata aaagatgatc 3018661 accactttta tattgacgcc atgctggatg ccaaggcgag aatctttctg ctgaagatag 3018721 gtgaattgct ggcggaaaac ggtgtcattc aagatcggga ggacctttgg ttcttatatg 3018781 acgacgaagt ggaacaagcg cttcttcacc ctgtatccct gcaagaaaag gctgaaaaac 3018841 gcagacagat ttttcatgag tatgagctgg cccaagcccc ggcctacctc ggcaccccga 3018901 caaaagaaca gctcaaagca gctgaagaaa ttgtcggcgc tgtgatagag gatgaaaaaa 3018961 acacagagaa tcatattttt ggcattgcgg catcaagcgg cattgcgaca ggtccggtga 3019021 aaatcattcg ggacgccaat gaattttctc aattcgcgcc tggagacgta ctcgtttgca 3019081 agatgaccac accgctatgg accagcctgt ttcaagacgc caaagcgatt attacagaca 3019141 caggcggcat tttgtctcac gctgcgatta ttgcccgtga atacggcatt ccagccgttc 3019201 tcggcacacg cacggcaacc gaaagactgc gagacggtga catcatcact gttgacggaa 3019261 gcagcggcaa aatcacagtt gtcagccggt cctgatgcgt ccccctcttt cttatacaag 3019321 cggggcgggt gtatacttgt cctgccagta tattcgtgag gtgaaacgta ttgagaccga 3019381 caaacaagag aatccttgat gctgccatgc agctgctcgt caaaaaagga tatcgcgcaa 3019441 cgactacaaa agaaattgca gaaaaagcaa atgtaagtga agcgacgatt ttcaggaact 3019501 ttaaaaacaa acaaggacta gttgaggctt tgctttctca gcattcttca aacagaggca 3019561 gcattttgga acaaacagaa ggggatttgt acaaagacct gcttcatatc ggaacctgtc 3019621 tcttggagga gctcgaacat agaaaagata tcattaaaat cagctttcgt gaaccggcca 3019681 tgtttcagga tgtcattaac cacgtcactg aatatcccca atctatgaaa cagctattgg 3019741 ttgattatct caaaacgatg ggtgagaaag gggttattca gacaggaaat gaagcggaac 3019801 atgccgacgt gttcatgtcg attatcttcg gttatttcat tcaccgtctc cacttaggag 3019861 accgggtcat atcaatgccc caggaaaaaa tgctggagca tagcacagct ctatttgtca 3019921 aaggaatttc tgctgattaa ctccttggca taataaaaag gaggatccca atgagctcaa 3019981 gaaaagaatg ggcgctgatc gtctcgctat tattgggggc cattctggtt cccattaact 3020041 caacgatgat cgcggtcgcg ctctcatcta tttcccatac gtataacgag tccatcgcaa 3020101 gcatcacttg ggtggttacc gtttatttaa tcgtgatggc agtcacacag ccgattgcag 3020161 gaaagctcgg tgacatgtac ggcaataaaa caatgtactt atggggagtc ggcctttttc 3020221 taatcgcatc tctaggctgc gccctttcac cgagtctgct cctgttaatt gtctttcggg 3020281 cattgcaggc tgtcggcggg gcattgctta cgccaaacag cattgccatt atccggcatg 3020341 ttgtttctga aaaacgccta ccgaaagtgt ttggattttt cggactgggc gcgggacttg 3020401 gtgcagcact cgggcctttt atcggctcta tactgattga cagcttcagc tggcattcga 3020461 ttttttgggt caacatcccg ttcctcgcca ttgctttatt tacggcatta acgatgtttc 3020521 ctcaatataa agaaaataaa tctgacgcgc cgctggatat catcggctct ctcttgcttg 3020581 caggcagcat cgtttccatt atcctgctga cgaaaaatga ggctccatgg ggatatactg 3020641 tatacagtgt attgatactt ctttttgttc cgcttttttt cagaagagaa aaacgtaccc 3020701 agcaccccat cattgacttt gcactgttta aaagctcaac ctttacaaat gcgaatctat 3020761 cagtcttgtt aagcaatttg atgatgtatg ccgtcttatt gattatgccg ttatttatga 3020821 cgaaccaatt tgggcttaat acatctaaca gcgggatggc gctttctgta ttttcgatct 3020881 tcatgtcagc cagcaactgg gtgggcgcgc agctccatca caaatgggga gccaaaaaaa 3020941 tcatttttct ttcatttgcc atgatggctg gtgcgaatct attatttttg ctgttaagca 3021001 gctcgcattc tgtcttgttc ctcatgctct ctcttatcct tggcgggctc gcttccggag 3021061 tcggtctgac cagcatgcag gtttcatccc ttgccacagt agaccccggt atgtcaggag 3021121 tggcatctgg gattttctcg accttccgtt atttcggaag catcatttca tcagccttaa 3021181 ttggcctgat ttcgggatat cacaccctat ttatgattct ctttgctgta tccatcatcg 3021241 gcgtttttgt ttcattgggc atcaaatctg atgaaacggc acggatagaa aaaaactcag 3021301 cgtaacacaa aacagcccgg catcgcatca tcctgcggtg ccgggctgcc ttttatgatc 3021361 ccgaagcgac tgcttcgtct tcacggtcat cctttacgaa gaggatgccc aattcatgat 3021421 gttctccttc ataagaagct cgctggtcaa aacgaatttc tccattcaaa ccgataattt 3021481 caagctttac atatgcacgg ttatgctgaa gcgcttcata gaaatcagaa acgttcttaa 3021541 ccggtatgcc attgactttc gttatgattt ccccgatttt caattccaga tcctcagccg 3021601 gcgtattggg gataatccca agcaccatta agccctgatc ccttttcgag aaataaaacg 3021661 gagccgcgtt atcattcact ctttgcttta tggacagaaa aatacgccct aacaaagcgg 3021721 tacagaccgc tgcacccgca agcggcgtcc acagtaagct cgctgcaccg agaactgcga 3021781 cggcaagacc gagaatacaa acgcgtttcg ctgtgatcct tatactcgtt tcaggcagcg 3021841 atccctgtac cctttgtcca aatccgacaa agtaaggaat ccatagaaaa tggaatgagc 3021901 cgccgggaac cgtaaacacg ggccaccagc taaggtgcga ttctaaacca ttaccgggca 3021961 cgagaaggaa cagcggcaaa agccaaaccc ggtttgccag ctgctgtccg atcggcaaac 3022021 cgcggctgct tacgacaagt gccggtgatg ttctcacatg cgcagaacga taagcaaccg 3022081 ctccttcagt gataatcagc aaacctagaa acacagccac agccggccaa acaactgcaa 3022141 atccttgcgg aaatctctcc agaaagggct ccgcctgata tatttgcagt ccaaaaccta 3022201 tcagcatact cacactgacg atatatgcag cagacatcca gtttgcgcga agagtgaacg 3022261 ctgccgctgc agtgataacg gcaataatcg caagtaaacc gagaggaatc gatattccga 3022321 gtccacctaa aataactgac aaaagaagac ctggaatcag tccctttgta tatgtaaatt 3022381 tcagatcatc ataaatatct gctattcttg tatgaaaggt ttttcgttcc cgtttgattc 3022441 ttacatagcc gaaagccaag gttatgatga taaaaaacca gaaaagcggg tgtaagaaga 3022501 acaagcccgc gctttttaac agttcaattc cccattgaac agacactatc tctcaccgcc 3022561 tcaagccaaa catgttactc atattctatc aaatattaaa tggcttggat atcctcagga 3022621 gagtttatct ctcttgcgtc atccacagcg tgacattcga tagtgaaaaa tcctttaaat 3022681 agtggtttac atccacatcc aataacccgc tgattagatg catcgacctt tttatatctg 3022741 tcagattaat tcctaatcgc ttatggtttt tcattaagta gttaaaataa tgtttggcgc 3022801 attcctcatt aatgtcattt actgattcga cattggtgta attgaccaaa tatctgctga 3022861 acagcataag aagacttagt gcttttgtag ctgaaaatgt tacgtcttgt gttctgtctt 3022921 ttaattgttc cactaattca taatattttt ttttcacgca caatacttgc cctcttcaat 3022981 tgtgaacccc cattttcttt atacagataa gcacgggcca gtataagcag cagtactgga 3023041 gtgctaacaa gcattctcgc taacgttact ctttaaatac ctgtcgttca gctgccatta 3023101 acctgattac tgttcttttt agaaccttct tatattgtat gaagtaaaca aagactaggc 3023161 aacttgcaaa agtttcattt taaatgcata ttaactcgtt agaaagtctc tctcatatat 3023221 tgatatcggg taataacagt cctttataaa tgtttatttg tgaaaatttt tttaatttct 3023281 tgtcaaaaac tcatttttta tgtgacttat gatccataat ctctttaagc acaaagaaac 3023341 aggagatgaa ataccatctc ctttaattga caaataatga tttcaatgct gtttgaagct 3023401 gcaaatcatt tttttcatct gattttttct tttctatctg ctgatttaat gtctctgcag 3023461 tgcgagtgtc gatcacaccg gttttattca gcttgttttg atcctgaaaa gccataaccg 3023521 cttttttcat gtctttgctg aaatagccat cctcacgtcc cggatcaaag ctgagacctt 3023581 ttaacaatac ctgcgcatgc ttgacgtctt cattgttcat gtccacttta agcggctctt 3023641 tcagctgtaa gggcccggcg gaaaaataat cgggctgctt aatcgcaatg gtcggttcaa 3023701 ttcctttctt atgaatccag tttccatttg gcgtcagcca cttgtaaagc gttaatttga 3023761 tgttgctgcc gtcccccatt ggcacagcct gttgaaccgt tccctttcca aaagacgtat 3023821 cgcctacaac atcataatgg ccagcttcct ttaatgcgcc ggcaagaatt tctgatgcag 3023881 aggcacttcc tttatccgta atcacattga cagggtacgc ttttttatgg gtcaatgttg 3023941 aaaaataacg ttttttatct ccattgcgtt cagcaatctg aatatacggc tgatcctttg 3024001 taacgaaatg cttaagaatt tcttccacac tttgaagata tccacccggg ttgccgcgta 3024061 catcaatgac aagtccttct atttcttttt tctcaagctc cctcagcgct tttgcaaaat 3024121 cctctgcggt gtgctcagaa aaagtagaga tggcaatata tccgacagaa tgcccctgta 3024181 cttttttctc tgatgcaaaa accgtttcga gcggaatctc agctctcttg atccggaatg 3024241 acaactgctt cttcgttcca ggccgctgaa tcttcattga aacgctggac cctttttttc 3024301 ctcttatttt taacacagcg tggtttaaat ccttgccggc catcgattct ccattgatgc 3024361 tgataatttc atcattaggc ttcaacccgg ctttttccgc tggcgatttc ttgaatggag 3024421 aaacaataat aattttgccg tcttccattc caacctcagc cccgatgcct tcaaatgagg 3024481 aatcaagaga atcagaaaat tgcttagctg tctgcttgtc catgtaaaca gaataaggat 3024541 catttagcgt agacagcatt ccctggatgg ctccctcgag cagcttttct ctatctactt 3024601 tttctacgta ctcattcgaa attaactcat acgctttttc gattttgtcc atagctttat 3024661 cccgttcaga gtcagcttgt gccgtcgcgg gaactgctgc agtctggggc ttatccatct 3024721 caagcaggtt gattcccgca tatacaccgg cgcctccgaa cagcatgctc cctgctgcta 3024781 tcacagccat tattttttga ttcatccttt actcctcctg tatgccagac tgtctttacc 3024841 aaaacctaga gatagtatat gtaaaggatg gagatttcat gtaatcatag aagaaaaaga 3024901 aggcaaatga aaagccgtcc cgaaaacgga acggcttttt cactttatac tcgcagaaac 3024961 ttgcggatgg aagtcagact tccccatact ccaattactg cgccgattgc aatcagcact 3025021 agcgaaactt ggaatacaaa tggattataa ggaagaagag agacaaatga tccttgaacc 3025081 tttggaacga cccatccgat gacgtattgg taagtgctca gcaccagtgc aatcggaatc 3025141 acagaaccga atacgcctag cagcaatcct tcaaggaaaa acggccagcg gataaaccag 3025201 tttgtcgcgc cgacaagctt catgatttca atttcttttc ttcttgcgaa aattgtaatt 3025261 ttaatggtgt tggaaattaa gaacatcgcc gtaaatacca ggccgataat taacgcgatt 3025321 ccgatgttgc gggaaacgcc gaccacttta aacaaacggc tgacctcttc ttttccataa 3025381 gtgactttat aaacatgatc cattttttcg atctttttcg ccacgttcgg cgtatcatgc 3025441 ggatctgtcg ttttgacgac aaacgcatca ttaagcgggt tttcctgatc cttcattgtc 3025501 agggattttc cgctgtcacc aaaactgtca accagctggt caagctcttt ttctttagat 3025561 gaaaaagtga cactctgaat gcccttcagt tccttaatat cgttctgaag cttgtcctgt 3025621 gccttctgat ctgcagtcag atcaatcagc actttgattt cgacttgttt ttctgcattc 3025681 gtggccatgt tattcaaatt cagcataatc actaaaaaca cgccgactaa aatcagcgta 3025741 acggttacag cactaatgga tgcaaatgtc atccatgtgt ttctcccgag agatttaaaa 3025801 ctctcacgca agtggcgccc gagaatttta atcatatgaa ccatactccc ctcttgactc 3025861 atcacgcaca atgataccat cttcgattgc aatgacacgt ttcttcatgg tgtttacgat 3025921 ttctttatta tgtgtcgcca tcacgactgt tgtcccgcgg ttgttaattt cctccagcgt 3025981 cttcatgact tcccaggacg tatccggatc aaggtttcct gtcggttcat cagcaatgac 3026041 aacatcaggg ttgttcacaa ttgatctggc aatagataca cgctgctgct ccccgcctga 3026101 aagctggtca ggaaattgtc gcgctttatg cttcagctgc acgagatcaa gcacttcaag 3026161 cacccgtttc ttaatgacag acggctgttc tccaatcact tcaagggcaa atgccacatt 3026221 ttcaaaaaca gtaagtttcg gaagaagctt gaaatcctga aagacaacac ctattttgcg 3026281 gcgcacgaaa ggaatctctt tttctttaat tgtcgcgaga tctttatgat tgattaaaat 3026341 ttgtcctttt gtcggttttt cttctctgta aatcatttta ataaaagtag atttacctgc 3026401 tccgctcgga ccaacaacat acacaaactc gccgggatga atggtaacag aaatcccatt 3026461 gagtgctttt acgccgttcg gataggcttt atatacttcc ttcatctcta tcatgaaatc 3026521 acctaatctt ttatatcatt ttatctatca cacggtcata ctcttcgaat gcattcgaca 3026581 atttatgacc cattcatttg taaaaagatg aaaaatctga aagttccctt tttcaataca 3026641 cttcattata cgtcaaattt agacataata ctattacagt ttcttttcat tcatattgtc 3026701 aaggcataaa aacatccttg ccagcactcg gcaaggatgt ttttatctta ctttttttct 3026761 gacagccatt tggcaataac agcggcttcg ttatcatcta caagcccctt tggcatattg 3026821 ccgcggccgt ttttaataat gctttcaatt ttgtgttcat cgtatttgcc tccgacctct 3026881 tggagattag gccctgacac accttctaaa tccttgccgt ggcagcctac gcagctttgc 3026941 tgatataatt cttccccttc agatgcagtg gcttccgtct tgctgccagt gtctgtcttc 3027001 tcttcttttg catcgtttga tccgcaggca gccaacagaa cagaaagcgc aaatccaatc 3027061 attagtatcg ataactttga tttcatgttg agaagcacaa ctcctttacg atctcttcca 3027121 tattataacc tcgtttaagc gcgtttgaaa ccctcgccca gcacctcgct cgcgtctgct 3027181 acaattacaa aagctgactc atcaatctgt ttgacgattt gtttcaattt ggtgaattca 3027241 gtttgcccaa ccacgcacat taaaatcgga cggtcatcgt cagtatatcc gccgactgca 3027301 gaaatttttg tcacgcctct gtcaatcttc tgtaagacag cctccttgac agcctgctcc 3027361 tgctttgtaa tgatgagcgc catttttgaa cgattaaagc cgacttgcac aacatcaatg 3027421 gttttgctgg acacatagac gccaagcatg gcatataagc cttgctcaat attaaataca 3027481 atcatagccg taacaacgat cattccgtca atgatggcga gacacttccc caatgacaga 3027541 ccggagtact tatgaatgat ctgtgcagcc aaggctgtac ctcccgtcga acctttccct 3027601 aagtacacaa taccaattcc gatacctatc ccgacaccgc caaaaatcgc cgccaggagt 3027661 tcatgatgag tggcgggctg aatatccctt gtcagaaaca ctactagcgg caaaaacaca 3027721 gaacctgcaa gcgtctttag tccaaatttc ccgccgagca aaatgacgcc agcaataaat 3027781 aaagggatat taataatcca ctgtacatac gctgcttcaa aaccatatga ttgtaaaatc 3027841 gtactgatcc cgctgacccc gccggcggca atcttattcg gaagcaaaaa tacattaaag 3027901 gacacggccg taatcgctgc tcctatcaat atgtatacat aatcccgcaa aatccacaat 3027961 gttttattcc gtacgtccat catatatcct ccgtttcttc caatgctctc cgatagcatt 3028021 ttaatccttc cctgattaga tgtaaataac acccaaatac agtggtaata tgctaaagca 3028081 gcagtgaaat caaggatata agaaataaaa aaacacaccc gtatgcatca ggtgtgtttt 3028141 tcagcttatg aaagcttaga acgcaggtag gcatcaataa acgtatcaat gtcaccatcc 3028201 attacagctt gaacgttccc catttctgta ttggtccgat ggtcttttac catggaatac 3028261 ggatggaata cataagaacg gatttggctg ccccagccga tttctttttg ttcaccgcga 3028321 atttcatcca gctctgcctg ctgctcttca attctgcgct gatacagctt ggccttcagc 3028381 attttcatgg ctctttcacg gtttttaatt tgtgagcgct ccgtttggca tgtcacaact 3028441 acgttcgtcg gcaagtgagt aatccgaacg gctgaatccg tcgtattgac gtgctgtccg 3028501 cccgcgccgc ttgcacggta cgtgtcaact ttaatatcct ccgtacgaat atcaatatca 3028561 atttcatcgt taaattcagg catgacttca catgaaacga aagatgtgtg gcggcggcct 3028621 gatgaatcaa atggtgagat ccgcacaaga cgatgaacac ctttttctgc tttgagatac 3028681 ccgtaagcgt tgtgtccttt gatgagcaat gtcactgact tgattcccgc ctcgtcacct 3028741 ggaaggtaat cgagagtctc tactttaaag ccgcggcgct ctccccatct tgtatacatt 3028801 ctaagaagca tagagcccca gtcctgtgac tctgtaccgc cagcaccagg gtgcagttct 3028861 aaaatcgcgt tatttttatc atacggctcg ctgagaagaa gctgaagctc aaactcattg 3028921 aactcttttg ttaatgactt tagttctttt tcaagctcaa gctggagatc agtgtccggc 3028981 tcttctttca aaagatcatg agtcatttgt aattcttcgt gggattcatt caatttttta 3029041 tacgaattga cataatcctt taaaccgttt gcttcattta taaccgtttg agctttttgc 3029101 tgatcattcc agaattccgg atcagccatt tgttcatcta gctcagcaat gcgggcctcc 3029161 tttgattcga ggtcaaagag accccctaaa gtccgctaaa cgagaagcca tattttcgag 3029221 ctctgctcta atttctgata attccatttc attcacctca ttaaaagatc cgcaggcgcc 3029281 tgcaggcgcc gcggtcagta aacttgccgg ggcgaactat tcagtacggc cgcagcaatt 3029341 tttatatttt ttcccgcttc cgcagtggca tggggcattt cgtccgatat caaccacttt 3029401 gcgaaccggt gctttctttg cttttttgtt atcgtcgcct tcttgcggct gatgagctgt 3029461 tgtttgacct tgtacaacct cttcacgctc cagattgttt tcaatctcag ctttcatcac 3029521 aaattttgcg acttcgtcct caattgattc aatcatatgc tcaaacatcg caaaaccttc 3029581 catttgatac tcacgaagcg ggttcgtctg cgcgtaagca cgaaggtgaa tcccttggcg 3029641 gagctgatcc atcgcatcaa tatgatccat ccatttagaa tcaacggcac gaagaacgat 3029701 aactttttcg aattcgcgca tttgctcttt gccgaattgc tcttccttct cattatattt 3029761 tgtgatgatg cgatccataa tgagctcaag catttcatcc ggttctttgc cgaagatatc 3029821 gctcttctca agtgcacctt catcaagata agttgtgttg ataagatcaa ctagaccgtc 3029881 aagcttccac tcctcaggaa gctcttctct tggcgtatag gctgcaattg cgcgttcgag 3029941 agaagacttg atcatatttt caacgatttc acgcaggttt tcagagtcaa tgacttcaaa 3030001 gcgctgctta taaatgacct cacgctgctg gcggagaaca tcatcatatt gcagaagctg 3030061 tttacgcgaa tcgaagttat tgccttcgac gcgtttttga gacgattcaa ccgcgcgaga 3030121 taccattttg ctttggattg gagtagagtc gtccatgccg aagcggtcaa gcatcgccat 3030181 tgtccgctca gctccgaatc tgcgcatcaa ttcatcttcc atagaaagat aaaattgagt 3030241 aatccccggg tctccctgac gtccggaacg acctcgaagc tgattgtcaa tccggcgtga 3030301 ttcatgtcgt tctgttccga ctacagcgag cccgccaagc tcttttacac cttcgccaag 3030361 cttaatgtcc gttccgcgcc ccgccatgtt agtcgcaatc gtaactgcgc ctttttggcc 3030421 ggcctcttca atgatctgcg cttcacgttc atggtttttg gcatttaaca cttgatgcgg 3030481 aattcctttg tttttaagca gcttagaaat caattcagat gtttcaacgg caaccgtacc 3030541 gactagaaca ggctgtcccg tcatgtaacg ctgtgcgaca tcctccgcaa ctgccttaaa 3030601 ctttccttcc atcgtgcggt aaattaaatc cgggcggtca tcacggacaa caggcctgtt 3030661 ggtagggatc gtgacaacct gcatgttgta gatgttgcgg aattcttctt cctctgtctt 3030721 agctgtaccc gtcataccgg caagtttttc gtacattcgg aagtagtttt ggaacgtaat 3030781 cgtcgccaag gtcatgcttt cgttttgaat ctcaagccct tcctttgctt caatcgcttg 3030841 gtgaagcccc tcactgtagc ggcggccttt catcagacgt cccgtgaagg aatcaacaat 3030901 aacaacctgt ccgtcttcca ctacatagtc aacgtccttt tgcatcgcaa cgtgagcttt 3030961 taaggcctgg ttgatatggt ggttgagcgc gacatgcttc acatcaaaga ggttatcgat 3031021 gccgaatgct ttttccgcct tcgtcattcc ttcttcagta agctgtacag cttttgtttt 3031081 gatatcgtac gtgtaatcct tctccgcttt taacgtgcgg acaaaagcat ttgcctgtac 3031141 gtacagctta gtggattttg cagcttgtcc agaaatgata agcggtgttc ttgcttcatc 3031201 aattaaaata gagtcaactt catctattac cgcaaaatga agcgggcgct gaaccatctg 3031261 ctctttataa agaaccatat tgtcacgcaa atagtcgaag ccaagctcgt tgtttgtgga 3031321 gtaagtaata tcagcggcat aagcttcccg tttttcgtct tttgacattg agtttaaatt 3031381 caaaccgaca gtcaaaccga gaaactcgaa aattttcccc atttgctcag cgtcacggct 3031441 tgccaagtat tcgttgacag tcacgacgtg tacgccttta ccggttaacg catttaaata 3031501 aacaggcagg gtagacgtta atgttttccc ttcccctgtt ttcatttccg ctatatttcc 3031561 gtcatgaagc gccacgcccc ccatgagctg gactttaaac ggaaacatgc ctgttacgcg 3031621 gcgtgaagct tctcgaacaa cagcgaaagc ttcaacaaga agatcatccg ttgtcgcccc 3031681 tttttcaaga cgctctttaa attcaattgt tttatgtttc aatgcgtcgt cagagagatt 3031741 ttcatagtct ccgcgaatcg catcaatatc gttagcaatt ttttcgtatc tattcagcgt 3031801 acgttttgtt ggatcaaaca ttttatttaa aattccaagc atttataacg ctcctctatc 3031861 atcacacgcc tattttagag gcatgtataa ataatttact agtccatgta tacctctcat 3031921 tatcatatca taccttttgt tatttccaaa gaatttgcaa ataagaaaaa caaaaacctt 3031981 ccgcggacat cacggaaggc ttctcttcat tattcagtcg gttcaattaa gccatatttc 3032041 ccgtcatttc tgcggtacac gacatttgta aggtttgttt ccgcatttgt gaaaacaaag 3032101 aaattatggc cgagcatatt catttgcaag atcgcttctt cactatccat cggctttaaa 3032161 ttaaagcgtt tctgacggac gatgtccaag ctctcctcct cttctatgtc atcctgaacc 3032221 gcaatatctg tatcagagcc aagaccgttt gccaataaat attttggaga gccctgctca 3032281 cggaatttac ggtttacttt cgttttatgc ttacggattt gacgttccag tttgtttgtt 3032341 gcgagatcaa ttgcgttgta catatcctcg ttatgcacct cggaccgaag cgccagatct 3032401 gtcatcggaa tcgtaacctc aaccttagac tccttgtcat tgtaaaactt caagttgacg 3032461 ttcacatcag catccacgct atggtcaaaa tagcgctcca gcttgccgat cttcctctcg 3032521 acatgatcct ttaacgcggg tgtcacttca atattttctc ctctgatgtt atagttcatc 3032581 aaagaacgcc tcccttttat taaggatatg tatctatttc tcttttaccc tttacaattc 3032641 ctgctgaaac ataaatcttt tgtgaaaatt cagtgaactt tgtcgaattt tgtttgtatt 3032701 tgctctgtta ttggcggctg ctaagctttt gaatcaaaca gtttcatttt gctacttttc 3032761 ggcagctcag ctttaattga tttgctgtaa ttgaagttat tttccttagg aaccagcata 3032821 tcgtacgaaa tagagatgaa ttgcagcgcg tctcttgtca gctgcctatt catctcattt 3032881 acttttttca gacgtccgag aacttgagaa agagattcgt atagttgttc cagctcttcc 3032941 ttttcactgc ctgaggtttt ggcgatacat gcggaaatag tattattttc gctatatccg 3033001 agaaaggccg aagttgtttt gatccggtca tcttctgtct gcgtgattgc ttgaatatat 3033061 ttttgctctt ttgtcaaaat gttagaaagc tcttttgttt tgccggcttt gagcgcttcc 3033121 gtcttttctt cagacagcgt gagcaggtgc tcatgcagaa cgcaaagtcg cttcaattgt 3033181 tcaataattg ccttcgctga catgggcttt ctcctttttt attgcttttt ataaaaatta 3033241 atcatatttt tcgcaatatg atttgcgtct actttgtatg acccgttttc aatttgcgct 3033301 ttaagctgcg caattttttc ctgtcgtgaa ccagtgactg cgtcggatgc atgttgcatt 3033361 tctttagcct gtgatgaaat ttcaatttta tcttgaggtt gtgcaacagt tttttgcacc 3033421 gcttgcttat cataattttt ttgatatgga ttaacggatt gtgttccaaa ttgattgatt 3033481 ttcataggat tcctctcgct ttccgttgca gtctttaaac aatcttaacc cttttatcga 3033541 ctgcgttttc agttagttta gggaatcagc tgtttttggt attataggca tagtatgtgt 3033601 cttttttact attttctttc tcgattttca gagcatcctc gtggttcaaa tgatccattt 3033661 gatccttaat atcagactgg caagccttgc agaacttgcc ttctctaatc gatgtcccgc 3033721 acctttcaca agggtatgcc aaattaggaa gatgagtgat ctgaattcgc ttctgcctga 3033781 tgaatttcaa tatcagctct tcttccacac ctgtttcctc agttatccgg ctcaaagttg 3033841 attgccggtt ttcctgtttt cttaaaaatt tatagacagt ctcaaatgat ttttcttctt 3033901 ccttaataca cgcctgacat acggtttgca gctttgtttt taaaaataaa gcattgcatt 3033961 tcggacaatt agccagttct cccatctttt tttctcctta ttagataata tgcctgtgtc 3034021 aatttctagt gattatatcg gcataaaaac agaatcattt agcttctgat caaggtaaaa 3034081 gatgacactg aagcggcttt tcctttttct aataagcagc gggctgcgaa gtgcaaggtg 3034141 gcgcctgttg tataaagatc gtctattaaa atgatattca taccttctgc tgaattattt 3034201 tttgtatcaa aaatgcactc tgacagcagg cgttctgttt tctttttctt tgactgtttc 3034261 tcattattca ggcgaatgag gggatggtgg gaaggccggt ctaaacattc tgccaagaga 3034321 tgtgcctggt taaatccgcg ctcttcttcc cgttccttgc tcagcggaat aggtacaaga 3034381 acaaaatgct tatcggggta aaccttagaa aaggttgaag aaaaatcact tttaaatgca 3034441 tttatgattt ctgcatctcc tctaaattta aaacgggaga gcgtttcttt catcatatca 3034501 ttatatgtgt aaactgaacg gttttgacgc aatagcaaac tgtctctgat ccttgttctc 3034561 cacacctcgc aatccctgca tacggcatga acagattgag gtctgccgca cagggggcag 3034621 atatgtcctg tgattttctt taatttgctt ctgcaagaat aacaaacctt ttcatcaggc 3034681 tttagtaaaa aaagggctct ccatgtaaca tcttgagaaa attgcgaatc acataataaa 3034741 cagatcagtt tatgaatgcc tcctcctgct tcgtttgaca taaatcgctt ggactctctg 3034801 aaactactgc agcagattca gccaaaatga caagcattgc tgtgtttttt tgtttatcta 3034861 ccagctcagc tttcgtatat gcgatctttt taaaatcagt aacgtaggat ggactcactt 3034921 tgtttaaaga aagtgccaat acatcgtttt ggcatacttg gcaagtacag gccatatgaa 3034981 gctggtccat atatcggtcg agcagttctt tcattacgat ttcttttgaa ttgacaagca 3035041 tttttacagc tcctcatcat cggttatatg agtatactgt accacgtttt caaataatgg 3035101 ctagtctgta cattcaactt ttgctgccaa ttcattcatt tcttttatat gctttcttgc 3035161 atcgagcata ctctttgttt tgccgaagtg aaagtaaatg acatcgccgt ccgcatattc 3035221 tttatgccgg ccggttcttc ctgcaatttg aacaagtgcg ctttccgtaa agatagacga 3035281 ttccgctcct agtacacccg tttgcacctt ggggactgtg acgcctcttt ccagtattgt 3035341 tgttgtgatt aatagatcga gctgaccatc tctgaattgc tgcactttct cctttctatg 3035401 cttgtcttcc gcgtgcacag atgcggttcg gcaatgaaca cctttaaagc acgcagcagc 3035461 cttttccaga atagaaacgg aaggaacgaa taaaaaaaca ggcctccctt cttttacatg 3035521 aaactctatc catcttttca ccgctggcgg aattttattt cggtttaatt tcttcttcca 3035581 gtttccacac catacaaagc gcggttcggg taaaggtttc cggtggtgtc ttgcggggat 3035641 gcgaactgaa tgtaactgtc cgttcagtgc ttttcttttt aattctttag gaggtgttgc 3035701 acttaaataa acgagggtgc tgtttttctt tcttgctttt tgaacagcga attgaagggt 3035761 ttgatcagca gaatatggaa aagcgtcaac ttcatcaatg atcataacat cgattgcatc 3035821 tttatatcgc aaaagctgat gcgtagtgga aatcataagc ggagatagcc gccctttgtc 3035881 atcgcttcct ccgtaaagcg ctgaaatgtc agcaccctga aaggcagcct tgagtcttgg 3035941 agcaagctct aatacaacat cggtgcgagg tgttgcaata catacacgca gtccttgatt 3036001 taacgctgat tctataccag gaaacagcat ttctgttttg ccagcgccgc aaaccgccca 3036061 gatgaggagc tcttcttttt ttgatattgc ttcaattaaa acattggcgg ctttttgctg 3036121 tccgcttgaa agcttgccat cccatgtcag cttaatagac ttccagtttg attcattttc 3036181 ctctttccat gaatataaag gaacctcctc actcactctg cccatcatga cacaggaacg 3036241 gcaatacagc ttattctttc cagatgagtg ataaaaagaa aaataccgct gatcagtttg 3036301 tccgcaccta ttacatctat atctccgttt atttatggat atagaatttt cagcagtgat 3036361 atatccattc ttgatatgcc attcaatcat ctcatcggaa aatgagagct cagtcctgag 3036421 caaatgacgg cttcgaagcg tctgctgcaa ttcttttgaa aaggaactgt ttttttcaac 3036481 tggcacattc acatagcacg cctcctttcg aaacagtatg cctgaatgaa tattttctgt 3036541 ccaactatta aaataagaat ataaaaaaat ctccgctcta aaaacggaga tttggcctta 3036601 tttaaaacac cagcaaattc ctaacgcacc ttcacccaaa tgagtgccga ttaccgcgcc 3036661 aaaatagctg ttataaaatt caacatgagg atattttgca gaaagctctt caatgatttt 3036721 cgctgcttct tcctctcgat tagcgtggat aacagcagct cgcataggca accctttact 3036781 cgcatcttcg tctaaaagct cataaattcg cgaaattgct tttttacgtg tgcgaatctt 3036841 ctcaaaaggc acaattacct tattgtcaaa atgaaggata ggctttacct ttagaagact 3036901 accaatgaag gcttgggcgc tgcttaatcg cccgccgcgc tgaagatggg ctaagtcatc 3036961 taccataaaa taagctcgaa ctgttttttt catttcttcc agttctttta taatatcttc 3037021 cggcgatgat gctccgtttt tgattaattc agcagcttta agggcataaa agccttgagc 3037081 caagcagctg atctctgagt caaatggata cacatcaata ttgtcgacca tcgaatcagc 3037141 cgctgctgca ctgctgaatg ttccgctgat cccgctggaa agatggatac tgataaccgc 3037201 atcataagac ttgccaagct cttcatacaa cgcaaccagc tcgccgattg gcggctgaga 3037261 agtcgtcggg agctcattat gttttttcac ttcttcataa aagcttttcc agtccaactc 3037321 aatttcttca cggtaagtct cctccctaaa aacaacctgg agagggatca tatgtatctg 3037381 atgttgttca cgcatttctt tcggaatata tgccgtgctg tctgttacga ctgcaatatt 3037441 catagcttcg atacctgcct tattgcttta taactctatt gtaagggaaa cggcagccta 3037501 aaaaaagacc tgcctagtaa aaggcaagtc tcctattata ctatctcatt tctacccagc 3037561 catttttaat ggcgaccaca acggcttgcg tccggtcgtt tacattcatt ttttgtaaaa 3037621 tattgctgac atggttttta acggttttct cactgataaa caatgattca ccaataccgc 3037681 ggttgctttt tccgtctgca agcatctgca gcacttcaca ttcccgccta gttaaaatat 3037741 gtaatggtct gcggatttca gggtaaacct catgttgagg gtgtgcagaa actccgcttg 3037801 ttgcaaggcg gcggaattcg ttaacgaggt tgtgagtaac cttcggatgg aggtaagatc 3037861 cgccctcagc cactacttta accgcttcaa ttaatgtatc agcatccatc tctttcagca 3037921 gataacctct tgcacctgtt ttcagggcat gtgttacata attttcgtca tcgtgaattg 3037981 atagaataat tactttagat tcaggataca gctctacaag ctgttttgta gcttccacac 3038041 catttacgtt tggcatattg atatccatga tcacaacatc aggatgatag tgctcaacaa 3038101 tacgagccgc ttcgtccccg tcatcacctt cggctaccac ttcaaaggta ggttcaaaat 3038161 ccaatatccg tttaacacct tcacgaaata actgatggtc gtcgataata acaatgttta 3038221 ctttagtcac aagccacgcc tccttgtatt attgttctat atactctagc attcggtcaa 3038281 tatgcctttt ggctctattt tacaaatcat agtcaaagag ataacggaac cttaatcata 3038341 ataaatgtcc caagacctat tttcgaatct attgtcatcg ttccttccaa taaatctact 3038401 ctttctttca tgcccagcaa gccgaatgat ttgtttttct tctctttcgc ttccttcagg 3038461 tcgaaccctt taccgttatc ttttatcatt aaaatcacaa aatcctttgt gatctcaact 3038521 ttgactgtaa tttcttcaga ttcagaatgc tttagcgcat tagacacagc ttcctgtgcg 3038581 agcctgaaga gcgcaacctc aaactgaggc gctagcctct gatcctctgt ttctccaatg 3038641 cactgaaaat gtattttgac cttcccgtta tattcctcgg ttgtatatag atattttctt 3038701 aaagttggaa tcaggcctag gtcatcaagg gccatcggtc ttaaatcata tataatcctt 3038761 ctcacttcgt aaagggcatt ccgaacattt tggcggagat ttttaatttc ttggaatccg 3038821 tcctctgcgc cccggtcacg gaaaatccgc tcgattaatt ccgatctcat cataacattc 3038881 gccagcattt gagcgggtcc gtcatggatt tctcttgaga ctctttttcg ctcttcttcc 3038941 tgcgcctcaa taattcttaa gccgaaatcc tgttttgcct gagcatcagc aagaagcagt 3039001 ccaacttcgc gcaaatcctg attcaagtag ttgagcacaa ctgtaatttg gcttactaat 3039061 gattctgacc gctcaatgat ttcctgaagc cctagcaatc tgcgctccaa atcgtcccgc 3039121 cgttcgcgca attgcttctc acgctgctgg atcatcgtca attctacctg cagcttatgg 3039181 gctttttcat aagcattgcg gatttcctct tcactgaatc tatgaaaatt acggctgacc 3039241 tcggataaac ggtttctcgc atggcgagtt tgcacttcaa gtttatcgcc aagctcaatc 3039301 acttcataca cctgctgttt aatttgtttc agttcttcga ccagctgttc atactgctgg 3039361 cgtgactgct ccccgatttg aaaaacctcg tccttgctcc cgtcaacggt tttcagcatc 3039421 ttcatcaaaa tagaatccag cactttggaa tccatctttg ttttattcat aatttccctc 3039481 cgtcacggcg ttgtcatata tttttattat aaatgtaatt gatctgcaaa ttatgtcgaa 3039541 ttataatgaa agaatgcgta tattctagaa aaaaacattt ttatatacta tctactcttt 3039601 atgataccaa aatacgcaca aaaattctaa agactgtacg aatttgtata ggcagtcttt 3039661 tatgcttagc aggagggtca gctagcatgc tgcacagcta ttttactgtg aaagaagcgg 3039721 gagaacacga gattgttata gaaaaatcgc gttttatctg tcatttaagc cgtgtttcta 3039781 ccgaacaaga ggcacaggaa tttatacaga aaataaagaa acagcactgg aatgcgactc 3039841 ataattgctc ggcttatgtt attggcgaga atgatcatat ccaaaaagcc aatgatgacg 3039901 gggaaccaag cggtacagcg ggagtgccga tgctcgaggt tttaaaaaaa cgcaggctga 3039961 aggatacttg cgccgtcgtt acacgctact tcggaggcat taagcttggt gctggcggat 3040021 taattcgcgc ttatgggaaa tcagtgtctg aaggattaaa tcatataggt gttgtagaac 3040081 ggaagcttat gcgaatcatg catacttctg cagattacac atggcttggc aagattgaaa 3040141 atgaattaag ggagtcacaa tttctgttaa aggaaatcca ttattcagaa aatgttgaat 3040201 tcgaaacata cgtggaagaa aaagaaacca acgctttttc tgaatggatg acagaactga 3040261 caaatggaaa gagtgatatt aaagagggag agttgacgta tcttgaaaaa gccgtcaatc 3040321 acataaagga gactgaataa tggctgaacg cgttagagtg cgtgtgcgaa aaaagaaaaa 3040381 gagcaaacgt aggaaaattt taaaaagaat aatgttattg ttcgcccttg cactattggt 3040441 agttgtaggg cttggcgggt ataaacttta taaaaccatt aacgctgcgg atgaatcgta 3040501 cgatgcccta tcccgcggga ataaatcaaa tcttcgcaac gaagttgtag acatgaagaa 3040561 aaaaccattt tctattttat ttatgggaat agaggattac gcgactaaag gacaaaaagg 3040621 gagatcagac tctcttattg ttgttaccct ggatcccaaa aataaaacca tgaaaatgct 3040681 gagcattccg cgtgacacac gtgtgcaatt agctggtgac acaacgggaa gcaagacgaa 3040741 gatcaatgcc gcttacagca aaggcggtaa agatgaaaca gttgaaactg ttgaaaactt 3040801 cttgcaaatc ccgatcgata aatatgtcac agttgatttt gacggattta aagatgtgat 3040861 taatgaagtc ggcggtattg atgttgacgt gcctttcgat ttcgatgaaa aaagtgatgt 3040921 agacgaaagc aaacggattt acttcaaaaa aggcgagatg catttgaacg gcgaagaagc 3040981 cttagcatat gcccggatga gaaaacagga taaacgcgga gactttggcc gtaatgacag 3041041 acaaaaacaa atcttaaacg cgctgattga ccgcatgtca agtgcaagca acattgctaa 3041101 aattgataaa atcgcagaaa aagccagcga aaacgttgaa accaatattc gcattactga 3041161 aggtttagcg cttcagcaga tttacagcgg ctttaccagc aaaaaaatcg acacattgag 3041221 cattacaggt tctgatttgt atttagggcc taacaacaca tattactttg aacctgatgc 3041281 tacaaatctc gagaaagtca gaaaaacgct tcaagagcat ttagattata ctcctgatac 3041341 aagcactggc acttccggta ccgaagacgg gactgacagc tcaagcagtt ctggcagcac 3041401 tggcagcact ggcacaacaa ctgacgggac gacgaacgga agcagctatt cgaatgacag 3041461 cagcacaagc tcaaacaaca gtacaacgaa ttcaacaact gattcatcct attaaaaaat 3041521 gcccggtcct tttagaggat cgggcatttt tgcgcagaaa aaaactccgg cacataagcc 3041581 ggagttttta attccttttc accagccgtt tataaaactt tgtaaacggc ttaaattttt 3041641 cattcacgag tcctgtcact tctgctatga tttgcataaa aataatcaaa atgaagataa 3041701 taaacaaaga aagccaaatt gtggcacttt taagtacaat cgcactgata ctgaaaataa 3041761 atccaattaa ataaataact aagaccgaca tccgatgtga aaggccaaag gccatcagtc 3041821 tatggtgaat atgcgactta tcaggcgctg aaatcggctg tttgtttaat attcttctga 3041881 tgatagcaaa tgttgtatca aaaatcggta cgcctaatat aataatcggg ataacgatac 3041941 tgaacaatgt gacactttta tacaggccta ataatgaaag aatcgagata ctatacccta 3042001 aaaacagtga tcccgtatct cccataaaga tttttgccgg atggaagttg taaaacaaaa 3042061 accccagcgt gctggcaata acgactaatg agagtgacag aatgagcact tttccgccgg 3042121 atagcgccat gacagcaatc gttgacaggc cgataacaga aagaccggca gcaaggccat 3042181 ccaatccatc aatcaggtta attgcgttcg tgatgccgac aatccataat accgtcagcg 3042241 gataagccat ccatcctaac tcaaatcgtt ctgttaaaaa aggtactgag aaaaagtcca 3042301 tttttaagcc agtgcttaca atcataatgg ctacacctaa ttgaatcaaa aacttaactt 3042361 ttgcacttaa ttgatattta tcgtcaagaa tacctaacac aataatgatg aatgctccga 3042421 ctgtaattgc cgtcatcctt gtttctgtgt aaataccgga tgcaagcacg cctgcaacca 3042481 ccccgataaa tatggccagc ccgcccatgc ggggcatgat tttgtcatgt acttttcgat 3042541 tgctgggctg gtcaactgca cctattttaa tcgcaatcct ttttacgatt ggggttatga 3042601 ttaaaactgt cagcagcgag acaataaacg caacaacaat gcgaatcatg cgttcgtcaa 3042661 gcataaagaa gtctcctttg gaattaaatg aagtctttat ttatatagag aaccgttcct 3042721 tccattatac cttctcctta gttattataa caagcttcat caaaaagaaa cacgtataat 3042781 caaaaaacgc gcatcccaat ttataggact acgcatgttt ttgaatccct gtatatttca 3042841 taatttgtct aaataagcaa ttccaatctt gtgtccgggc gatgtttcgg cgcatttctt 3042901 tataggtctc gtctccgttt tgaccgagaa ctttttcaca agcggctata aaatcaatcg 3042961 gatgatcgcc ctctacatat tcgtatacat acggcttttg catttttgag gttgacggaa 3043021 gattagtgcc tacaacaggt tttcctgccg ctaaaaattc aaatagtttc agcggaaaca 3043081 cagcttgatt atacggtgat tgtttatatg gcataatgcc aatgtcgata agctccatat 3043141 aatgaggcac ttcttttgga tctgccggac cggtccatat gacattggga agcctcagca 3043201 gctcttgaaa cgaaacatca ccattggtgg catccgggcc aacccataaa aatgtccaat 3043261 caggcttttg cagtgccgct tctttaatca ttttaaaatc gagcttcggt ttaatcccgc 3043321 caataaaacc taacactatt ccttctctcc cctgcagtat actgcgatcg ggagcttgtt 3043381 tatttgcaga aaacagctca tactccacac cgttttccac agtatgaacc ttttctcgtc 3043441 ctgcagtcag ttttttgtct acttccttgt gaagataatc tgatgaacag gttattgaat 3043501 ctgctcgttg tataattctc agctctgccg atttaatgac ttttcgccgg aattcagaca 3043561 gcagatttga tcggccgctg atcggcgcag cccataggtc actgcagtca taaatgacct 3043621 gatcccaaga atacagcgaa gacagcagcg ggaatccggg aaacgtgtac cataaacagc 3043681 agcgttcacc gtttgcagaa gcaggtgtaa gctcatcgag taatggggag agcttatgtc 3043741 tgtaaaagac atctgtatat cgtccgaaac gaaacatttt tttctgcagc aggtctttga 3043801 cagcgaattg cctgatgcca gaatggactt cctgaaactc tttcccttgg gcacgcggag 3043861 ccggacatac ccaaataact tccttcgttt cctcctgagc agctaaaaat tctgccagcc 3043921 ggtgccttct gtatctcaat tggtcttttc cccattcagc agtggcaacg atgacatgaa 3043981 tgattgcttc ttttgtttcc accttcatca ccttttctct ctgtttgcag ctataatctt 3044041 tttttcaccg cgttttttgc atattgaaca aaacaccatg ttgctttcat aaaatgaagc 3044101 cgttcgatct ccctgtagac aaaccacgtt tttttcgcag ccttccattt gttgctggaa 3044161 attgaattat tgacaagccg atattcagcc aggcattcat tcattccata ggcagtaaat 3044221 ccttttttta aaagagacag ccatgtggct aagtcctgtc tcgttctgat attcggcatt 3044281 tggatctgtc ccgtttgctc cctgtcaatc atcaccgtca agcagccgat aattgtattt 3044341 ttcagggcgt catcgtacgt caggctttcc ggcgcatgaa taaatttatc gagcggggtc 3044401 ccgtcctgcg ccattaagct gtagcccgtg aaagagaacg cacaggagcg ctccatcata 3044461 aactcaagct gcttttccag tttgtctttt ttccatttgt catcactgtc caaaaatgct 3044521 acgtagcgcc cttgagcgcg ttccaacgct ttgttgcgag caaccgcagc tccggagttc 3044581 tcttccagat acaccacatg aattctttcg tctatttttt catactgctg taaaatgtcg 3044641 cgggtcccat ccgttgagca atcatccacg ataatcattt cccaatgagg atggctctga 3044701 tctaataccg aatgaaccgt gtcttcaata tagtcacgcg cattatagga aggtgtaatg 3044761 acagatacga gaggtttcca attggtcatg atcacatctc catcgtatga ttttaaaagg 3044821 attctctgaa aaattcagga atgacaacga acataaaggc aatcgtaagg ccaatcataa 3044881 cgccgagaac tgctttcttt ttcggagaca taccgccgcc tgctgtctca cttacggttt 3044941 cggaatcagt aacacttgcc gctttcaggt taagctgtgt gtttttgagt tcatataaaa 3045001 atctctcttt atccactttg gaatcctcgc tcaccgactc gccttcaagc gcgtctatgc 3045061 tgctgcggat gacggcttct ctttctgcat acagcttttg atcgtttttg aggaaggtgg 3045121 aggatatggc gtttaagaca gattccgttc tatccttatc ctcgtcacta tagcttaaag 3045181 tcagtaacga tttggattcc gtattgattg taagcttctc tttgatctct gctacatctt 3045241 catccttttc atcaggaagc gcctccttca aaaaggagtc gctctttaat agaagcggaa 3045301 tctcttctgt gctgttataa accggatgat catagctccc cacagccaaa gtatcttcag 3045361 ctgtatagct cttttgatca gcgatctgtg acggcaggat ataccccgcc gcacctaata 3045421 taattggcac cgctatgatc caaatgatat ttttttttat gcgacgggct attcttatca 3045481 atatatcgtt catataagtc tccctgcttt ttgtagtctg tttatctgta catcggctca 3045541 ggcatttgtc tggatcgcct taacacattc acggcggcga tgacgagcgc cataaacacc 3045601 caatggaaaa ataaatttga aacagagctt gggctgatac ttgataccag gaaactgacc 3045661 atagcggtaa taagtccttc tgtgatcagt tttgactgat tttctaattt tctttcataa 3045721 aacttgtaaa gcacccatat gaggtaggca taaacggaca aatatcccag catgatgaac 3045781 aaaccaaaat tagcaagaat ttcaacaagc cagttatgca cctctgccac attgtcagta 3045841 tcatatacag cataatgctc aagataatag gatacatttc ctgccccgac tccgaatccg 3045901 tatgaatcaa ggaaaaaatg ccaagcgttt ttcagcagat ttgcccgagc cacatttgat 3045961 ggaagcctgt catgaaatga atgcagcgtc tgcggggcca gaaacagctc ccaaaacttt 3046021 gaatagattt tgctggcgaa aagaactgcg aaaagagcaa ttcccgccgc cgacagccat 3046081 atagccattc tctttaaaac aggcggcaat acaatgaaga tgtagacagc aatacctgca 3046141 aaaatgccca gaaggctggc tcttgaacca gtggcaaaaa ttaaatacaa cgcacagagc 3046201 gagagcacaa ggccaattgc cttgatgtat ccattcttaa tgtttttcat catcgtgatg 3046261 taaaaaaaga agctgatgga taaaaaggtc gcaaagtcat tttgattaaa aaagaccgat 3046321 gtcggataat gctgcttgta ctccggtccg ctgtacaatg tggaactcgc aagatgatgg 3046381 tgggtgatat gattgtaaaa accaatgatc atcagaaata ccgtcatcac cagccaaatg 3046441 gcataaacaa tcatcagccg ctccattttt tgcacgtaca tgacaataag ataaatgaag 3046501 aagatcccca ttgccaataa ggctaaatac ttgaggccaa ctgttaccga cttggcccac 3046561 agcagagaaa caaggccata tataaaccaa aaggcgaaaa agagtaaaat cccttttact 3046621 tgcagcccat gccatctttc aatatgggtt cgattccgaa ccatgccgaa aatatgaagg 3046681 caacccgctg caatgagcag aagccggtaa aggaacaaac tgaaaaatcc aagatgaatg 3046741 gcaaaaaatg cattatttaa aaaagtgcag gcgatcaaaa tatagattac agccataaag 3046801 agccgttctt ttgttgtaaa tgcggttgca agcgtcagta aaaacaggcc aattgccaac 3046861 accgcaagca cagcagccat ctgcatgaaa cctatatctt tatggatggc tcccagcaat 3046921 aggacgactc caaatatagc agcggccagt aacgctagcg tatggaccgc tgatcgtttg 3046981 atactcacat gtttaacccc tttcctgatg tttcaggagc cggcggccga gcctagcagc 3047041 cggcagcttc aaccaagtaa cactttttct ttttataaat tgacgcttcc caagtcttta 3047101 gccaattctt caagcggcaa gcccggaaaa tacttgtcag agggttccgt tccccgaaca 3047161 gcgggacggc cgatagagtg ataaatgtat ccggctgcct gcatctcttc aagtgaaaat 3047221 aaatttctgc cgtcaatgat gactggctgt tttaagaggg ttttcacttt tacaagctcc 3047281 atttctttca cttccggcca atccgttaaa atcaggcatg catcagtgtc ttccatcgca 3047341 gcatacacat ctgtgtaata ctcgacctgt tcgccaagga tcgctgaagc ttcaggaata 3047401 gcaatcggat cgtatgcttt tacatgggcg cccagctgct gcagcattgg gataatatca 3047461 agcgctggag cggatctcac atcgttcgta ttcggtttga aggctaatcc caggactgaa 3047521 atggttctcc ctttgacgct tcccataaca gtcaaaagtt tatctacaat atgaacacgc 3047581 tgcttttcgt tcgtttcaat gacagcttcg atgagcttga atggatagcc tgccgatttt 3047641 gcgatttgaa gcagcgcggt tgtatccttt ggaaaacatg aaccgccgaa tccaatacca 3047701 gctttaagga actttctgcc gatacggctg tcaagaccaa caccatcagc aacttttgaa 3047761 acgtctgcgc cgactcgctc acaaatgttt gcgatatcgt tgataaagga aatctttgtc 3047821 gccagaaatg cattcgcggc gtatttaatc atttctgcac tttctaggtt tgttttaatg 3047881 acaggagcat ggaatggctg atgaagttcc tcaatgatgg cagcggcttt atgacttgtt 3047941 gaaccaatca cggcacgctc catattcatc gtgtcatgaa tcgctgaccc ttcccgaagg 3048001 aattcagggt tagatacaac atcaaatgag tatctcccct ttgaggcttt ttgaacgata 3048061 gattgcacca gtttccctgt tccaaccggg actgtgcttt tatttacgat cactttgtag 3048121 ccgttaagat gctcaccgat tgttttcgcc gccgctttga cgtacgttaa atcagcttca 3048181 cctgttttgg acataggcgt tccgactgca atataaataa tatctgaggc ccgaatggca 3048241 gacgggatat cgttcgtaaa ggtcaggcgc tgatccagca catttttttc aactaagtct 3048301 gcaagccctg gttcatagat tgggattacc ccatttttca ggcttctgat ttttgattca 3048361 tcgatatcac agcaaacaac tttattgccg atctccgcaa agcaagtgcc tgatacgagt 3048421 cctacataac ctgttccaat gacagctatt tttttcacag cgctcaaccc tctcctgtaa 3048481 aatgatcttc caatttataa tggtcgcagt gtcttacgat taaacggacg ttttcgtgac 3048541 cgtctgatac tgatgatgca aggccttggc gttttttcct gcgtcaaatt gagcctgcac 3048601 ggtttcatac aagtcatctg ctacttccgg cttccatatt tgctcatgtt cgtaccgagt 3048661 gatcgcttcc gccaaggctt gagcggattt cggtttaatc agcagatgtt ggtgctttcc 3048721 gaataaagac gacactccgc caacatccgt acaaataaca ggaaccctta gcgccagcgc 3048781 ctcaatcaca acagtcggca tcccctcact gtaagaagga agtacgaata gatctgccgc 3048841 aagtaaatag tctcttacct gatgattcgg gacttggcct gtgacgatat gccccttctg 3048901 cgtcagcgtc gattttgcgg gaccatcccc gacaaagact gccttaggag agtcctgcag 3048961 cgattcgatc gcttcagaca gttcaaaaat gcctttctct ctgaccagcc ggccgacata 3049021 gacagccaga cgctgatcga gcgggagtcc gagtcttttt ctgatttcct ctttcgtctc 3049081 ctcattcccc tgaaaacggc tgagctgtat gccgattggc aaaaccgagc tgtcaaagcc 3049141 cgaaagcttt ttggcttctt cctgaagctt gtggctgact gctaaaacaa ctgacgcaga 3049201 acctacggca cgcttgaagg ctttaaacgc acctttgctg taatgcggat agacattcac 3049261 atcactgcca tgcaaggtca ggacataagg aatttgcgct gactctgaca cgactgccgc 3049321 agccccgccc gatggcatgg caaaatgcgc atggatcaga tccggatata ggtcgcgctg 3049381 tttcattgtt tttaaaacgg ctgatgcgat tctccgatga ggctgcgccc acttcagctg 3049441 gccgggaact gcccgataga aaggccggta aaccggtatc ccctttctaa tctcatactc 3049501 cggtctgaca tccttttttc gatatgtctt tttcagcatg cggacaggtg ctgaatgaaa 3049561 aggccgtggg catatcacag tgatatcaag cccgagtttt tgcagctctt gcacctgtgt 3049621 ctcatgaaac acaccctctc cgggtttcat actgctcgga tatacgcttg tgatccacaa 3049681 aatcttcatg acaaacgtcc ttttcttagt agtttgcttt tcgtttgagg gtacgctttt 3049741 accaaaagaa agagatagca cagcgcccca gccgcaactg aaatggccag ccgcatttct 3049801 gcctgcatac tgaagtgttc ggtactgagg cttacaccaa acgcgatgat gcccatcgcc 3049861 gcagtaatca gaaatggctt cataatcgac tggaaataag ctgaaaggtt aagcttgatg 3049921 acatatgcca aaagccagcg cccaatcagg aaattaacaa cgctgataat ggcatacacc 3049981 catgcgactg tcagcaggct tcccgtctgt acagctgcaa acagtgataa tccgtacagc 3050041 agcagcacgc cggaatccca ataaaacgct aagtcagctc ttcctttagc cagcaacaca 3050101 gatccatttg gattcatgag cactcttagt attccgacaa tcgcaagaac atttaggatc 3050161 ggaacagcag caagccattt ttctccgaaa accgctgtga taaaggcgtc tgacacagac 3050221 acgagcccga ttaacagcgg aaacgaaaca agcgccagca tttttgtcat attcagaaag 3050281 ccttctctga tcacgctgtt ttcatatttg ttttttgcga aaatagggaa tgccacccgt 3050341 gtgacaatcg gattgatctt caaaaccgga atggtgacaa tctgataagc gaggttataa 3050401 atccccaatg cttcagcacc aataaaccgg ccgatcaaaa tcatgtcgat atttgctccc 3050461 agcctgttca caagacggga tgaaagctga aaggctccaa aagaaaagaa atccttcatg 3050521 cctctcaaat caaaaacaaa agcaggatgc cacttttttc ggtatacagc ccaatataaa 3050581 atccctttac tggactgcag caggacttga gaaatcacgt acgccaaaat cgcatccatc 3050641 ataaaaaccg ctatcgctaa atatccgaat gacaatacat ttgaaaaaat ctctattttg 3050701 cttaacgtat taaaatgcag ctgcttttgc agcatatact gatattgctg tccaattggc 3050761 gcgatcaaaa acataatcgc cagaatccga accagaaaca ccagctcttc tctttgataa 3050821 aatcccgcaa tgacaggact gctcacatat aaaagaacaa acagcaaaac gcccgtcata 3050881 atgttaagcc aatacaatgt tgacagctgg cgctccgtcg cgtcgtctct ctgaattaat 3050941 gctgcgccaa aacccatatc gagcacaatc tgggcgaaaa ctgtaaccgt tgtgatcatg 3051001 ccgacaagcc caaattctgt taaggtcatc atatttccaa gcagggcaaa ctgaacaatt 3051061 tgtatgattg taatacacat ggttgaaata cttgtccact ttgcaccgct catgatttgt 3051121 tttgtaatac ttggcatcat attccctact tctttttaag ctcagattga tggtgaataa 3051181 tggaatcccg ttttatcttg caccatcacc cgtccaaact actttacaag tttttaacat 3051241 aatttttaat tctaaagtga aagtcagatt gcgaatgtaa tataaatcaa atatcagctt 3051301 ttccttcggc gtcatatcgt aaccgccgtt cacctgagcc cagacgctgt gtaaagcctg 3051361 gaatctcatt ctggaatttt tccgtaaata cgggccgttc cggacgaggg ccaatcatac 3051421 tcatatcgcc tttcagcaca ttaaacagct gaggaagctc gtcaattctc gttcttctga 3051481 taaaagctcc gatccttgtc acccgcggat cttgcttctg tgcccaaacc gccccagact 3051541 tctcggcatc tattttcatg gaacgaagct tataaagctt aaatggcttc ccgcctttcc 3051601 ctacgcgttc ctgcgtataa atggcaggcc ccggcgtctc caaacaaatc aaaattgaaa 3051661 ataccgcaat cattggcagc gcaatcgcca atccaatgag cgcaaaccaa atatccatta 3051721 cgcgctttat tgccaaataa cgagccgtct tttcagataa tgtaaaagaa tgtatttgtt 3051781 gaactgagaa ttcacgactc acattcatgc ttttctctgc actcactgac acacacctca 3051841 cgatttgttt gggatgttat gatgacctat gccagtcagt ttagcagacg gatgttaatt 3051901 ggatgtaaat ggtatgttaa gaagtgtgaa ttacgtgttt tttctgataa atgttgttaa 3051961 tactctttta ctattttata tacaagtcct atttgtttta atcatttcat ataaaaaaga 3052021 gacaaatctg tgattagatt tgtctctttc gattatctgt aataagatac tgtgccgtca 3052081 tgaatagctt gtgcagcttt atctttataa accgcttgct tcaatttact tgcatctgat 3052141 gcattagtga taaaggcagt ttcaactaaa acactcggca ttttagaata tttaataaca 3052201 tagaaagcag ctgtttttac tccccggtct ctcgttccaa gattagccgc taactttggt 3052261 tgaatttgtt cagccagtct cttgctattt gcagcttgat atgttgtatc gtagtacgtc 3052321 tcacttccat ttggtgatga gctatcatta gcatttgcat gtatactgag aaataaatct 3052381 gcttgtgcag aagctgcttt atttactctc tcctgtaaag aataaaaagt atcattagat 3052441 cttgacagta ctggaagagc acctgaagca tttagctttg tattgactct tttcgctata 3052501 tcaaggttga cttctttctc aaggagtcca ttgccgattg ctcctgaatc ttgatcaccg 3052561 tgacccggat caataaagat tgtttcacct acaactggat tctttagctg attagcaacc 3052621 tttgtgctta cggcaggagt gtttccgata atcataaagt ttgacatgtt tttacttcca 3052681 ataattttac gggctcctgt agataaattt tcaccatttg taagaataag agattgcttc 3052741 ttcttagctg ccagtgtagc tcctgcaata gagtcagggt agctgaatcc attgcttaca 3052801 tatacggtgc ttgttgataa attaagtttt tgtacgatat ttgcagcaag ctcatatctg 3052861 tttgaaccgc taattcttgt aggagaaggt aacttgttgt ataccgtatt gctgatactt 3052921 ccagtgcctc ctacaacaac ggtactcgaa attcccttat cttttatcac agacgtagtc 3052981 gcactattta tagatgtttt atttgtaaaa agaattggat acccgttttt cgctgcataa 3053041 gggatgacgg ccggagcgtc tgcatataag aagccgttca aaataacagc ttttgaagtc 3053101 gcacccatcg cttttgccac ccgtgcagcc gtatcataac ggttgcttcc tgcaattcgt 3053161 ttaatactta tccccaagct tttaatctgg ttagcagtgt tagaagaaac agcaggtgtt 3053221 ccgcctacaa taattacatt tttagtctgc atctctttca atcttgtttt cgtttcatat 3053281 gaaagcttat cagaattagt gtaaagcaat ggcgcattct tctggtaagc aagaggtgct 3053341 gctgaaatag catctgcata ggaactccca ccaacaatta cagctgtact tgctgttgaa 3053401 tacatttgct ttgatatttg tacagcagtg ccgtatctat tgcttccccc aactcttttc 3053461 actgagttat cggccaaagc tgttggcaca aaaagtatga gccccagaaa acacattgtt 3053521 aggactttta tataagaacg caattgattt cctccttaaa tggcgttata tcctaaaata 3053581 atcaataact tgtcagagtt gtacctggat agtaaaattt caaaattgaa ctatatgaat 3053641 ctccagcttc tgctcttgct tttgctccat attgactcat tccgatcccg tgaccatatc 3053701 ctttaccgct gattgtgtac tttgaagtat ctttttttac agtcacataa gtacttttaa 3053761 atacagtcgc tccaatcatt gttcttaact cacttgttgg tacactaatg gttgtaattt 3053821 tgctcaagtt ataggagcca gtactgcttt taacaaaata cttcactttc atcgatgctg 3053881 tttttgcacg ctgcccttgt gtcgttccac taaagcttaa atcgtcaata cttgcaattt 3053941 tgacagaatc agcgcttgtt tctttatttt tcaagatcca gttcttaact ccggaaagtc 3054001 ttgcagaatc agtttcagtc gctgaagacc accaagaaga aggcttcgtt aagtccaaag 3054061 atttcgtatc tagctgttgt tttgacaaag taagcgtcca gcctatttga ggatcctttg 3054121 tatctttttt tgcaatcaag taaggtacac ttgacgacca cacttcatta ctagcttctg 3054181 tgtaaccacc attactggaa gaataagctg cagttataag agatccatta tatttcagaa 3054241 ctttcccctt cgtttgctct accgctttat tggtattcga attccaactg tagccaccat 3054301 aaacttgaaa agcggttgta tcaggtacag tagttcctgt ttttgttatt gagtaggttc 3054361 ttgcagcgac agtctgtgct ttaagagcct caagtgacca gctagcaggc atttcattcg 3054421 gaattactcc ttttaagtaa tcctcaaatg gaatattctc atttaccggt cggatatatt 3054481 tagtagactc aatagagaaa ttaaccgtgc caagatactg ctttccatca agactaattc 3054541 tgtttgaagt agaatagttt tctggtttaa ttcttaggga gtttccgtaa gttttgatgt 3054601 tttcaaggtt taattttccg ctgttgattt ttagattata ggtgccaccg tcagctaaat 3054661 aaaattcatc agcaagtgaa ttctcaactt cagcagaaat tgaactggta cttccaataa 3054721 agtcgtatgc atatgtggct ttatctttcg ttatactttt agccgcagcc ggaacgctat 3054781 cttgtttaac aaataaaatt tggctgtttt tcttcgaggc aagcgaagcg cctatcaata 3054841 cgtctgcata ttttgtcccg ttcgtcatta cgactttatc agccttcaac tttagttgct 3054901 taattatatt tgccgtaagt tcatatctgg ttgatccagg aatcctttgc acagttgaag 3054961 tttttttaat ttggttttct acactatcac tgacgctaaa tgaactgcct ataatgatga 3055021 cttgttttgg caaatcataa tccggaagct tgtctttctc tgtaagcaaa atagggtatc 3055081 cgtgtgctgc tgcatatgga gcaatggcta aagcgtcttg aaatactctt ccggttacaa 3055141 cgatcgcttt atcatagctg cccatttgct ttgcaatatt ttctgataag acatatctat 3055201 tttttccgct tatccttttc acagcgccat atgatttcag cttgttttct acgtcttttg 3055261 aaatgcttcg cgctccccca atgattaaaa tattatcagg gttaaactta gcaatttgtc 3055321 tttcagtagt ttttgttaac gtgtcaggct gagtaaataa aactggtgcg ttcagttttt 3055381 tcgccaatgg aataacaggc aatgcatcaa taaaaatatc tcggttcacc aatatcactg 3055441 tattaggatt tttccactgg ctgttggatg caagagtcgc agtttcgtat cgtgaagcgc 3055501 ctgcaaaacg atccgtaaca gcaacattat ctccagttac tttataaaat cctgttggcg 3055561 atagactgat gctagattta tttccaatat aatttaacaa tttaactgag atgtttgagt 3055621 ctgctgcaaa agaaactgat ggaatcaata ataagattgc agcaagtgaa cacactatca 3055681 attgtttgca agatttcaaa atttcaggtt cctccctata tcttagttgg cacgttcaat 3055741 atcttttaac agaagctgac cctcatcatt tttttcatat gtaatcgtga ccttatctcc 3055801 actgttaaac ttatcaagat cacttgtcga ttcttcagtg atatcaagac taaccggctc 3055861 attatctact gttacttcta ttgtatgagt atcagctaac cctacataag taccttcttt 3055921 tgtttcaatg ttactgtctg gcgatacatc ttcaccttga ctcttttgac tattaacccc 3055981 gcaacccgaa agaagcaata taaagaacag taaagcaata aattttttca tttttttcac 3056041 ctcattatat tttatcgtca acctatttta tattttaaag aaaaattaag aaacaatgaa 3056101 actttttttt ataaaaaacg actattttag gatttcattc ttgtattaaa tagagttgta 3056161 tttattggaa atttaactca taatgaaagt aatttaacag acgaggtgca aaggatgaga 3056221 aacgaacgca gaaaaaagaa aaaaacttta ttactgacaa ttttaacgat aatcggactt 3056281 cttgtactcg gaactggcgg ctatgcatac tacttatggc ataaagcagc ttcaaccgtg 3056341 gcaagtattc atgaaagcat tgataaatct aaaaagaggg ataaagaggt cagtatcaat 3056401 aaaaaagatc ctttttccgt cttaatcatg ggtgtggatg aacgcgacgg cgataagggc 3056461 cgtgccgata cgctcattta tatgaccgtt aacccaaaaa cgaatacaac cgacatggtc 3056521 agcattccgc gtgacacgta tacaaaaatt atcggaaaag gcacaatgga taaaatcaac 3056581 cattcatacg ctttcggcgg cacacagatg acggtagaca ctgttgagaa cttcctcgat 3056641 gttccggttg attattttgt gaaagtgaac atggaaagct ttagagacgt tgttgataca 3056701 cttggcggca ttacagttaa cagcacattc gcgttcagtt atgacggtta ttcgttcggc 3056761 aaaggagaaa tcacgctgaa cggaaaagaa gcgctcgctt atacccggat gagaaaagaa 3056821 gatccgagag gcgacttcgg acgccaggac cgccagcgcc aagtcatcca aggtattatt 3056881 aataaaggcg ctaatatttc ttccatcacg aaattcggag atatgtttaa agttgttgaa 3056941 aataatgtga aaacgaactt gaccttcgat aacatgtggg atatccagtc cgattacaaa 3057001 ggtgcgcgga aacatattaa acagcacgaa ctaaaaggta caggcacgaa aatcaatgga 3057061 atttactact accaagctga tgaaagcgcc ctttccgata ttacaaaaga gctgaaggaa 3057121 agcctcgaaa agtaaaacaa aaagaagctt cgcacaatgt gcaaagcttc ttttttattt 3057181 gcctgtaaat gaatccggtt gttcttttcg atacccgtaa tgaaacagca attcttccac 3057241 aatccggcgg gaagcctctc catctccata cggattagaa gcctgggaca ttttcttgta 3057301 ctcatcagga tcagttaaca gctgttttgc aagctgataa atgttttcct catccgtacc 3057361 tgcaagtttc agcgttcccg cttccactcc ttcaggccgt tccgtcgtat cacgcagaac 3057421 aagaaccggt ttcccgagag atggggcttc ctcctgcacg ccgcccgaat cggtcaatat 3057481 aaaatgcgat ttcgctgcaa agttatggaa atcgatcacc tctaaaggtt caatcagatg 3057541 cactctgtca gaatcaccaa aatgcttatg agccgcttcc cggacaacag gattcaggtg 3057601 cacagggtaa acgacttgta catcttcaaa ttcccctaca attctgcgga tggccttaaa 3057661 catgttttcc attggctcac ccaaattttc ccggcggtga gcggtcaaga gaatcatttt 3057721 atcctcaccc acctgatcga gaacaggatg tgagtaacca tccctaaccg ttgtgttgag 3057781 tgcgtcaatc gctgtattgc ccgttacaaa aatagagtcg gcctttttgt tttcttttaa 3057841 taaattgtct ttcgcctggc ctgtcggagc aaaatgcaaa tcagcaatcg cccctgtcat 3057901 ctgtcgattg agctcttccg gaaacgggga atacttattc cctgtacgga gccccgcctc 3057961 cacatgaccg acagcaattt gatggtaaaa agcggctagg cttccggcaa acgtcgtcgt 3058021 cgtatcacca tggacaagca caatatcggg tttgatatct ttaaacaact catccaatct 3058081 tacaagtgcg ttagacgtaa tctctgccag tgtctgccgc tccttcataa tgttcaaatc 3058141 gaagtcaggc ttgatgtgaa acgcatctaa cacctgatcg agcatctgtc tgtgctgtgc 3058201 agttaccgtt acataggaat ctatttcagg atattttttc aattcaagca caagcggtgc 3058261 catcttgatc gcttcaggcc tggtcccgaa aacggtcatc acttttagtt ttttcatatt 3058321 tgtcacctgg ttttctgcta tagtaaataa attcatacta catattctac atgaaaatgc 3058381 atcattttaa atcatttcat tcttgattca aataaaatga tataagtttt aatattaagg 3058441 ataaagcttg tttaaaaatg gtttatccga tatcataaaa atgtgtaaaa acatattgaa 3058501 aagggtaaat agagaatagt ttaaccataa attttttcga tcataaggaa ggtgcctttt 3058561 aaatgaaaaa agtacgtaaa gccataattc cagcagcagg cttaggaaca cgttttcttc 3058621 cggctacgaa agcaatgccg aaagaaatgc ttcctatcgt tgataaacct accattcaat 3058681 acataattga agaagctgtt gaagccggta ttgaagatat tattatcgta acaggaaaaa 3058741 gcaagcgtgc gattgaggat cattttgatt actctcctga gcttgaaaga aacctagaag 3058801 aaaaaggaaa aactgagctg cttgaaaaag tgaaaaaggc ttctaacctg gctgacattc 3058861 actatatccg ccaaaaagaa cctaaaggtc tcggacatgc tgtctggtgc gcacgcaact 3058921 ttatcggcga tgagccgttt gcggtactgc ttggtgacga tattgttcag gctgaaactc 3058981 cagggttgcg ccaattaatg gatgaatatg aaaaaacact ttcttctatt atcggtgttc 3059041 agcaggtgcc cgaagaagaa acacaccgct acggcattat tgacccgctg acaagtgaag 3059101 gccgccgtta tcaggtgaaa aacttcgttg aaaaaccgcc taaaggcaca gcaccttcta 3059161 atcttgccat cttaggccgt tacgtattca cgcctgagat cttcatgtat ttagaagagc 3059221 agcaggttgg cgccggcgga gaaattcagc tcacagacgc cattcaaaag ctgaatgaaa 3059281 ttcaaagagt gtttgcttac gattttgaag gcaagcgtta tgatgttggt gaaaagctcg 3059341 gctttatcac aacaactctt gaatttgcga tgcaggataa agagcttcgc gatcagctcg 3059401 ttccatttat ggaaggttta ctaaacaaag aagaaatcta aacaaaaagg ctattggaca 3059461 ttcatccaat agcctttttt tatttcaaca tcaaagtcaa tgtatgctct tcattatcaa 3059521 ctgcgaagac ctgatcaacg gcctgccgca aaaattaata atcccagaca aacacactga 3059581 ttgtagagtt aaacaaacta aatgaaaaca taaatacaaa catgcagatt aaatagtaaa 3059641 tatcttgtat tcaatgcaag ctaagtaaac accacttgct aaaagaacaa tgactaaaca 3059701 accagcatta caaaataatt aaataaattt gaagcaatta caacagaagg cagtgaactg 3059761 tcggaaagtt cattttggct accatattaa tccctttaac tacgctgttg gatttatcaa 3059821 gaattgtcgg gctaatagaa aaccacggaa tcaaaccagc cagcattcaa acgataaaag 3059881 gcacttctcc gatacctgtt atgaccagct tactgttgcg catcccaaat acaaaccagt 3059941 acgccatcat tagaataagg ggatttaaaa cctgccataa tacaccaaaa taattgattt 3060001 tttggatctt tcggttaaag aaatttaaaa gtaccagtga atattgtaac aaatgttgag 3060061 tttttttcac ttttaaaaag taaagagaag tctcgcagaa cttctcccaa catttgaagt 3060121 gtcaatataa aacaaaccaa cctcatttag caactttatt attatctaat tccaaaatag 3060181 cattataaat acgattccta ttatttttat cagtatatgc aaaaaagtta tctactcttt 3060241 ttctatactt atcttccata cgactattgt ttttcatata atagataact ttatccacta 3060301 agctattatg attttctaat acatcaccaa accccatttt tttataatca taataatcaa 3060361 gtttaaaatg gtatgacttt tcgtattgat aataaataac aggttttttc tcatatgcaa 3060421 aatcaaacgc aacagatgaa aaatcagtaa tcattatatt agaagaatta aatagcattt 3060481 gatagctgct gttatagtcg gcaaactcca cataatcatg cttttcaaag tctacaatct 3060541 gttgctgaat atctgggtga ggaaaaaaag ttattttata attatttttc ttagcaaatt 3060601 cgattagccg ttcatcatta atcaaagcat tatacctaga aaaatattca ctatctttaa 3060661 atttcgggtt gtacggtctt actccttttg cctgatcttt cggtaataca atatcttttc 3060721 tccaagtcgg cattattaga agttgctttt ctccctcact cttcttaaga ttatcgtatc 3060781 tcggaaatcc acccaacaaa atattctctt ttttatagtt gtaattccct ttcacaatag 3060841 accgatattc aggtttggca gaagtgacta ataatttgat attcttgttg tatttgttta 3060901 accattcaga atgatctgcc attgttattc cgtgctgtaa aaagataaac tcaaagttaa 3060961 ataaatctct aaaataaatc tccatattaa aaaatggatt tacaacccat atatctgcat 3061021 gtgtcgatat tactttggaa gaggataagg ttaaaatttt atgtctaaaa gatctgtatg 3061081 gtatgacctt tccatatttt ttgattctgt cgtaatcctt gctatctttt tttattataa 3061141 agtatttttt taccccatca ttcttgttga ttgcatattt aaagaggtgc tcggcattat 3061201 catcagcttt gtcttgtctg tctatgaata accatactgg ttttctatta aaaatagtga 3061261 aaacatggtg taccattctt gccatcagtg ccttcttaat cgctgatttt cgtttttttg 3061321 atttttcccc tgatttatgt agggatttta agaaacgaaa ctcttttata aatctatttt 3061381 taaaattgtt ttttttgaac attaattttt tataattata ataaaaaata taatcttttt 3061441 tagccacata agtattatat aaatcgtttg acaaacctga atacttgaaa aaacgaagtt 3061501 ttgtcaactt ccttttttta cccttagtta taaaaaactc aatatgatga ttatctgcta 3061561 gatgaccttt gggaatatct attgaaaaac cgggatattt ttttattact tctcctaaac 3061621 ttatataatc attatgctgt ctttttatat tctttgcttt tatttttgtt tcgccaattt 3061681 tagcataaaa cttaaaacct ttagaattaa acagcgagct ccaaaagcct tctatgtgaa 3061741 tggaatcctc attttcttct aaaatttcaa tagttaaagt ttgatccgat aatttcgaaa 3061801 caattttacc ttctctgtat aaataataat cctgttcagt ttctctttca tatacatacc 3061861 tactataatt ttcaccgtgc tttattttta aagcatgata taaatagaaa tggctgacac 3061921 tttttgtttc aatgatgaca tcgtcgtcaa tatacgacaa tacttctcga atcaatgtta 3061981 aaaattcact gtattcattt tcgtctaaag gtgtttcact gatatcctta atcaataatt 3062041 tccacttcaa atcatgcata accatatatt gaagaaataa aggtattttc tgttcatgat 3062101 tttttataat atcgattaaa ttctttgaga aagtgataag tgaatggtta aaccaattct 3062161 tatttgcttt agcagtctgc atggcagatg atccatcttc tctaactcta taatggtatt 3062221 ttgcctcttt aaccagacca tactttttct tttgcgatat gattaaatta actagtttgg 3062281 catcttcacc tattttacaa ttttcatcaa acctgatatt tttcaaggca tcttttttta 3062341 taaatgtaga acaacaatga gttaatatat gatgcggttc tttttctaca tccaaaattc 3062401 ttgtagaaga aaacttatta tttagattat gttctccagt tcttccttct gcaaaaaaaa 3062461 tagggattgc tacaatatca atttcattct tatgttcgtc aaagaagttt aaaacatttt 3062521 cgaatgttcc ttctgaaact aaatcatccg gatccaaaaa ttgaatatat ctaccttcag 3062581 catactttaa accataattt cgagcactgc tcactccgcc attctgtttc tttgcataga 3062641 caatgttatt gggatatttc tgagcatatt ctttacaaat gatttcactt ttatcggggc 3062701 tatcatcatt caccagtatt aactgaatat tctcaaaacc aatagtttgg ttaatgatac 3062761 tttctatagc ttcagtgaga tacaactcaa cattataaat cggcattata acactgaaat 3062821 catagttaaa acttttttcg ttcataaaag attactccta acataatgtt tatatgaata 3062881 agaattcggg taaataaaat taagaaacaa gagagtacta atttttgcaa aacaatttta 3062941 atttagtaaa atgtatgaaa agcattcctt accttttttt aaaaaccctt gtaagcaaac 3063001 ttttaaaaat gttcacatgg ttaagttcta aagaatcatt tggtgttttt agtacaaagt 3063061 caaatgcaaa ggcccaaatc ggtatttcga caacaaaacc agcatatcta aaatctctta 3063121 atttatatcc ccatacttca attgtttttt tcagttcttt tcgtttgcat ttttttaatc 3063181 ttttaaaata ttttatatat attctgtcat tttctttcat ctcataatac tggttaataa 3063241 agtgccctgt taattcaagt ctaagccctt ttatttttgc cgaagtaaca gtacatgaac 3063301 tatgcagtac tctttctttt tttatatttt caagagcttc tgtattttct tttaataagt 3063361 gaaacataaa ttctttatag tacatcggca tatcttgttc ttttataaat tgcgggtcaa 3063421 taaattttaa aactttaata aaatcatcaa caaaaactct ttgttcttgt tgatctaaaa 3063481 cagacttata aacatctcta tagttcggat ataaaaacag ttttatatga tatacaatta 3063541 aaaattgcaa ataaggcaaa actatatcat atttgttgaa tgaatccatc aacaaagtca 3063601 tgtaacattc attcaacaaa tatgtgtacc tttttttgtt aaaccatgaa cgatcaacta 3063661 aagaatcctg ttctttccgt tttctataaa aatactttcc ttctgcaact gctccgtatc 3063721 ttttttcttt cagtaataac tggttaaaaa agatagcgtc ttcccaaaac tttatagatt 3063781 catcaaaaag gacggtacta gttagtgtat gtcttctgta aaaagtgccg ccaatataaa 3063841 aatgaatagc tttataatcg ttgagaatat ttataactct tgttcctttt tcaaatctat 3063901 tatttaattt atgtccccct tctttttcac ctgtgtaata aacaggtaat accgcaatat 3063961 ttacatgttc ggaatcacaa aaaaaatcat aaacactttg cagcgcattt tgagagaatg 3064021 catcgtcaga atcaagaaaa ccaataaatt tagatctttc gcttacattt gataatccac 3064081 aatttcttgc agcagaaggt ccagagtttt caattttcat gattttaata ttattaggat 3064141 atagattttt aaaggattca caaatttgag gactgctgtc aacactacca tcatctatta 3064201 atatcagttc tatattttcc ttaaatccaa ttgactggtt aaggacactc tctattgaat 3064261 atcttaaata attttcagaa ttatatattg gtataattat agaaaacatg tttgtacctc 3064321 tttatttaga agttaaagga tcgtttcaat tactctttta gaagccttgc ctcttctaaa 3064381 ttacaaaatt tattataaaa atcctcatag ttatgatcta tataaggatt atgtaacaac 3064441 tcttttaccg tatctataag ttcttcactt gtttgaagca agtttcctgg cgttttttgc 3064501 tgaaaattaa agtaaaaacc tctgatacag tctctataag ccgggagatc atacacaaaa 3064561 aatacaaggt ttttttaaaa attcatatta tcaaaaaaga cagaagaata atccataatc 3064621 aataaatcac taattaaata taaatctcga atatctttat ttaaagaaac atcgttcaca 3064681 aaatatttat atttccctaa ttaaattgtt ctgaaactgg ataataccat tcttacaaga 3064741 ataaccatag agtctccaag gttccctctt catttcctct aatcaaatta aagttaaatt 3064801 tatactggcc agctttctta aaattcatta tcccgcaaag ttggtgcata taaaattatt 3064861 tttctttaat tccttatttg ataatgtaga attggtaggg gattgtagct aaactgtttc 3064921 cagaatagct ttcaaataaa attaatttat tgtttcttgg cagaaggaca aaaattttaa 3064981 acaaaactga ataaactcta actagtaaac ttctgcaatt ggttataata aaaatttcat 3065041 cagtgaactc cttaaagagt gaagattaat atttacgcaa acaagaaaaa aagaagcaac 3065101 tgaatttact tcaagcctct tttagttagt gcttctataa actagccata tcttttctga 3065161 tttgggtagt tgaaatgcct gctattcttg taaggtaaat ggcctcatag tattcctttg 3065221 tagacaatcg tacgattaag taatcccagg ttcttttgct ctttccagta gcttcatatg 3065281 tccatagtga aataaatcaa acattccgta cgtatcactt tcttcattag ataacatcac 3065341 cttccaacct tttccaactt agaaaaaaca aaaatcctta actgattgtt tatcatttcg 3065401 acatattttt tacgttccat taataataaa caataatagc atatgttcct ataaaagtta 3065461 aggctcttta aaaatgtaaa tcatcagcac tttttgacaa tatcgttgca ttgatgtgta 3065521 ttttttacag atctgatatc ttatctatac tcattacaac aagttttcta ttccggaaga 3065581 gtcaattctt tttgtcgcgt tttcaagtgt aatgattttc tttctgctgc gtcatttatt 3065641 ttgtacgccc tcctcatatt acttcatcgt caaaacgtga aggaattgta atacgtagtt 3065701 cctaaaaatt ttcgtggtaa aatttagtga agtctttatc aggctaaggg actttatcta 3065761 aactacgaat tacatatgga gatatataga tgaaaaggag ggttgatatg atataaacga 3065821 aaatcaatta gataaaggaa aaactgaaca cttctgaaaa aagtgataag tttctttcac 3065881 tatatcctcc aaaaagaacc taaaggtctt ggacatgctg tctggttcgc gcctaacttt 3065941 atcggcgatg agccgtttgc gtttctgctt ggagacgata ttgttcaggc tgacacacca 3066001 gggttgcgcc aattaacgga tgaatatgaa agaacacttt cttctattat cggtgttcag 3066061 caagtgcctg aagatgaaac acactgttat ggcatcatcg ccccgctgac aagtgaaggc 3066121 cgccgttatc aggtgaaaaa cttcattgaa aaaccgccta aagacacagc accttctaat 3066181 cttgccatct taggccgtta cgtattcacg cctgagattt tcatgtattt agaggagcag 3066241 caggttggcg ccggcggaga aattcagctt acagacgcca ttcaaaaact gaatgaaatt 3066301 caaagagtgt ttgcttacga ttttgaaggc aagcgttatg atgttggtga aaagctcggc 3066361 ttcatcacaa caactcttga atttgcgatg caggataaag agcttcgcga tcagctcgtt 3066421 ccatttatgg aaggtttact aaacaaagaa gaaatctaaa caaaaaggct attggacatt 3066481 catccaatag ccttttttta tttcaacatc aaagtcagtg tatgctcttc attatcaact 3066541 gcaaaaacct gatcatctgt attcacaaga aaacgcttct tgctgctgtc atacaataca 3066601 tcgctatcac ttaaggatag tgacgccggg ttgataggag aaatgttatg aaaaataagc 3066661 tctgttgctt tatcattctc cagtacataa ctgatttttt cataatcaaa attcagcgtt 3066721 tttctgccgt cagccttatt tccttcagta taaccattca atttcgattg aatgctggtg 3066781 ctgctgtctc ctaggaattt cagaaagtat tcataggaag atgctgcgtt ttgcgagaca 3066841 taagacgtaa atgcagtggc atgcaattca gcgtgtttca tgttagttgc aacagcgctc 3066901 tgtttcacat aataagagtg cccgtcaaac tttattttcg ctgcttgttt gccttttgca 3066961 gctaccgtta cttttgtacc gaatggcagt gtaacgtcag ccttctgttt caaaccctga 3067021 tccttataag cagccgcttt ttcatttgct ataaaccctt gcttattgat tgcagttaag 3067081 cgttcctctg acttgccctt tgcatcgcca tgatggttct tcacttcatt ttgcggaata 3067141 gcgccaaacg aagcaattgt acgaagcggg gcattaaaga acatcgttcc cgccatgaag 3067201 acagtcagaa tagacaaaat agcaatttga atggcattgg ccagtgattt cggctttttc 3067261 ttctttttgc ggaaacgggc aaacgcttca ggatcttctt tcttcctctc ttctgtctgc 3067321 tcttttttat atgtctcttt ttcttttttc gatagcttat taaaccagtc aataaacgct 3067381 ttgtactctt tcacaaccgt ttttgtttca tcaaacatac gaagctcgcc atagtgcatc 3067441 caagcaacac ggtcacacat cttttcaatc tgaccgattg agtggctgac aaagaaaatc 3067501 gtttttcctt gctttttaaa ctcatttatt ctgtctacac acttctgata aaacgtttgg 3067561 tcccccacag aaagagcttc gtcaataatt aaaatgtcag gatcaatatg cacggagatc 3067621 gcgaaaccga gacgcgactt catcccgctg gaatagtttt taaccggctg attaataaaa 3067681 tcgccaatct cggcaaattc aacgatgctg tcatacatat catcaatttc tttattggtt 3067741 aaccccatca tcaaacactt gagccggaca ttgtcccggc ccgttaattg gttattcaaa 3067801 ccggcagcaa tcgcaatcag cgacggctgg ccgttcattt caatttcacc gctggtcggc 3067861 ggaataattt tagccagcag gttagacatg gtcgattttc ctgacccgtt tattcctaca 3067921 aagccgattg tctccccttc atacacgtca aaggagacat tccgcacagc aaaaaaacca 3067981 ttatccttag ccggaaaaaa caatccttta atcttgtccg attgtttttt atacaaatga 3068041 tactgctttg aaacatttcg aaacgaaact tttagtttca tcgtaaaatc tccttacgta 3068101 ttaaagaaag tcaacaaact tgtctctgaa tttcatatgc aggatagaac ctactaacaa 3068161 taaaaggaat gtgaacaacc aaaagtacag cgtgtacttc atgtcatgga aaaaccatgc 3068221 tccatctaag aagctgttcc ggaatccttc aataatatag aatagtggat tcaacttcag 3068281 aacaggcact aattcggggt ggctttgacc gagtttcgca ttaacatccc aaaaaattgg 3068341 caacaagaaa aacaaaagtc ttgttacggc ctgcagcaaa aattgataat ctctaatcag 3068401 cacactgatc gttgagttaa acaaactaaa cgaaaacata aaagcaatca tacagatgaa 3068461 gtaataaata tattgtaacc aatgcacact cgggaacaca ccattaacta ggagtacaat 3068521 gatataaatc accatcatga tcatataact aaataagtta gatgcaattg ccacggacgg 3068581 tagagaacta atcgggaagt tcattttagc caccatatta atgcgcttaa atacactatt 3068641 tgatccatca agtatagttg gactgatgaa aaaccatggg attaatcctg ccagcatcca 3068701 aataataaaa ggcacttcgc ccgctccggt tgtcacagga ccgccctttc taatccccat 3068761 accaaatacg aaccagtagg ccagcatttg gataagcgga tttaagaact gccataagac 3068821 acctaaataa ttcatttgat atttagactt ggtttcataa gccgccaatc ttaaaattaa 3068881 aggaaatgac gttatttgct ctctgagtat acgcaacaaa tcattcattt tttatcttcc 3068941 ttagacttaa ttgtttttgg gaatctttct gtttaaaatt tgaaagcacc gctgattatt 3069001 gtaacagatc ctgcattttt tttcacttct caacaagtat ctaaaaagct gccgaaaaat 3069061 cgacagctat acattttata aaataaccta aattattcag ctttaaatac agtattaaca 3069121 accttttcag atgaacgtcc tgactctaaa tagcaaaact tatcatagaa aggaccaaaa 3069181 gaaaccggaa gcttataatc aggcgatgag atctgcttga tagcctcaat cgtttcttca 3069241 gtagttttta ccaaaggacc aggagcttct ttttcaaaat caaagtagaa accacgcaac 3069301 ttgtcccggt aggtttcgat gtcagggaca aagaatagca ttggccgttt taaatttgca 3069361 aaatcaaaga atactgaaga ataatcagta atcagcaaat cagaaaccat atacaattct 3069421 cgaatatcct cataagcaga aaaatcatat gcaaatcctt caaaaggacc taaatcaaaa 3069481 ttctcagcta ccagataatg cattcttaag attacaatat attcatttcc aagttcttgt 3069541 ctaagttgat gcaaatctaa atcgagatcg aacttataac gcccttttgc atagaactga 3069601 tcatctctcc atgtaggggc atataaaata acctttttat cacgaggaat atttaaccta 3069661 ctctttatca atgatattgt ttcctcatta ttatcattat gaagaaaatc atttctagga 3069721 tatccagatt caatcattgt cttgttaaac tgaaacgccc gtgtaaagat ctcagttgaa 3069781 taaccatttg gggaaatcaa gtaatcccaa ttagaagctt ccttgataaa attcctttta 3069841 tattttttgg tgtttgtacc aggcatatgg acttcttcca tatccattgc aagtcttttt 3069901 aaaggtgtgc catgccatgt ttgtaaatat gttgtatgac taggtttcgg aatccataat 3069961 ggaagccggc tgttaacaac ccaatactca gctcttgcca tagcgaagag ccattttaat 3070021 gagaggcgat taatgtaagg aattcccttt tcatcaaaag gcgctgaata ttgtttattt 3070081 acactccaat acattttata ctcagggtgg ttttcccgca tatattcgta aatcgctctc 3070141 ggattacaac tgtattgttt cccattaaaa ctttcaaaaa tgactgtttt ccttttaact 3070201 ggcattctgc tagccatcat gaatagagat ttgtatgttt tagtgattaa cttgtttctc 3070261 atttttgtga tcttttttat ttttgatact aatctcttct tctttccttt aataaagtat 3070321 ttcatccttg ttttcaggct atagtcgttt actctgatac ctagagtctg ctttttcttt 3070381 ttcttaaaga cttcataacg aactggtgcg ttgtttgttt taataatact tactaatcct 3070441 tttaatttgt tttttcgatc tcctaaaaca agagcagtgc tgttgaactg aatatccgtt 3070501 ccttcatcgt cattgcatat atactccata aaaagacgat aaacataacg tttttcattt 3070561 gagaaaggaa tttctttcaa aggcactttc acttcaaaat catacagttc cggaacaaaa 3070621 ccatctgctc tcatgttttc caggccatgt gtttttcttt ctagcttgat tggaaatttt 3070681 tcctcaatag gtgtttctcc accctttttt aaaataaggt tcaagttttt tatccgatat 3070741 tgattttcgg aactcaggta ccccgcataa cctgttatgc ttatttcttc agagctaatc 3070801 tcgatttgat caaatctgat gattttggcc tctcttttca ccttaataga aaagttgcct 3070861 ttatcagttg tataaggtaa aatcaaaagt tctgtggttt gatcgacatg aaaggcgcgc 3070921 tcaattgaat ttacttcagc agaaagacgc ttcaagagtg gttcctgctc cgcatcttca 3070981 tatttttttc gaaattcgac ataaaaatca tatgtttgtc ccatttcaac aggcataggc 3071041 aaaacatgag catttatctc agttttatac tctaatgagc cagtgttttg aagcggaaat 3071101 tcagattccg ttcctgaacg tctctctttc agctttaaaa ataactggta atcctctaaa 3071161 aattggtgtt ctgaatcaat tgagattaac aattcaagac ttcctaaatt gtttttcaag 3071221 cttttcaaaa tacatttaat cacagtgttt tcaatcatta cttttttctg ctcctctgta 3071281 taaaagctct ttcctttttg cttcctttta ttagtgtcaa ctactaagga cattaactct 3071341 cttttatttc cgtgaccctc caagagaaat tgcctttaac tgttgtatag ggctctactc 3071401 tatagccatt attagtatct atactgtttc ctgacaattt tgtttcttca ctcgaaagtc 3071461 ttcgcattgt tttaatatgg ccatttgcat tgaaaacaat ataaaaatca ataacttggg 3071521 ttttattagc agctatcttt tcaatattta catctttttc gagatcaatt acaaacagtt 3071581 gatcattttg taagtttgtt gaaataattt cagccttatt ctttctgtcc aagcccacta 3071641 aacgtatttt tttaatatca ttatgatcaa aattctcaat gtcaatttct attttagttt 3071701 tatcaaaatc ctcagtatag gaactaatag aaggatcttt ttttccaacc tttttagaga 3071761 acttctctct ttctattcgc acctcaatca tctgattaag agcaaaagcc caattttcaa 3071821 tatagttggg tcttgaatat ttttcagcca ttttaaaagc ttgttctgaa aatttttgat 3071881 gagtactttc atctttcatc aaagagataa tagcttgacc caatttctct atattatact 3071941 gttcaatgac atatccattt gctccgtcag taactaagct ccttgctccg taatcataat 3072001 cgtatgttac aactggacat ccattgctca gtgcctccat atttgataga ccgaaccctt 3072061 caaaatgaga ggttgaaatg gttagccaag ctttttgaaa ctctgagtca gggttatccg 3072121 tatagccttt caaaaagaca ttgttctgca gtttggtatc ttcaatttct ttttttattt 3072181 tttcgaaatc ttcacccgat ccgaatatat caagttttgc ttcaggaatt tctttcacga 3072241 ctaaactaaa tgcttttact gcatgtatca gatttttcat agatgcaagt cttgaaataa 3072301 tgacagcttt gtatttttca ctcggcacat tcaatacagc gggatcaaga ggcttatcaa 3072361 ttgtatgcgg agtaaagaaa aacgtctctt gttcccctga aatcaattta aaatcttcta 3072421 gctgctcctc agttataaaa aagacagcat ccaaattata catctgacta aatacttctt 3072481 tatagcgacc cttaatttga tatttattgc tgccgtaatg cttgttatga ataattgctc 3072541 cataatagga agaaggtgat tttttcactt taaagacatg tttgtcttgc ggtctgctgt 3072601 ccactaaaaa caacttaggt ttatcatttt gtttttgcag atattctatc caatattgac 3072661 gcagttccga ttcatctttt acttttatct caccctcaag ggagtaccaa ataatatgag 3072721 ataattgaac atctttttct tcattgttcc atacatagag tttgtctaaa tatacttgat 3072781 tttggtcatt aatatattcc tgcagataca tcttgtttag ctgcacatca taatgagtaa 3072841 cgagaactaa gtttccgttc ttcgtatatt cctctctctt tatgagctgg tttttatcat 3072901 tccaatagtc gacgtaccgg atagtttctc catctccgta gtaaactaca gacatttcat 3072961 tgttcttctt accaaacaat ctcaacagag tttttgcaaa tttccccatt ccaacttgct 3073021 tttttatctg gtcaaggcct atcctttctt cgtatgatct tttcccattt gttctaacac 3073081 ttaaaaaatc atcgaataga ttaataacac ttgtgaattt tttatcaatc ttaccgttgc 3073141 tgtacaattc atcaattttt gaagacaact ctaaatcaaa acgaaacgtt aagaaaaagg 3073201 tgttttggtt acactcttct ccaaataatt ttgaacgcaa taataatgat ttcgtcagac 3073261 cgccataatt acttggcagt ccaccagaga taaaataata atccatgtca ggaatttgtt 3073321 ttatattaga ttcactcacc gcatgtaaag acaatttttt actccctttc ggcatctaga 3073381 atatatgatc attgaaattt atatctaccc ggatacttta gtcacaaaaa tcaatgtaag 3073441 catcaaaaag tacttcttat ttcaataaga agtactttaa ttagatattg aaccaatgat 3073501 atcaggatcc taaattataa accagcaatt tcctctttga tctttgttgt agagatgcct 3073561 tctgttcttg ggaggtaaac aacctcacac tgatctttga gaaagtcaaa tttaccttcc 3073621 cagtcatccc ccataacaaa aacatcaata ttatgatcaa taatatcttg ctttttttgc 3073681 tcccaattct tttcaggaat tacttcgtcc acatatcgaa tggtttctaa aattaattta 3073741 cggtgctcat agctgtgata agcttttttt tgcttttgta aattgaattc atccgttgaa 3073801 atagcaacaa ctaaataatc accaagctgc tttgcacgct caagcaattt aatgtgaccc 3073861 caatgcagta aatcaaaagt tccatatgtg ataacttttt tcatttaaag aaacgctcct 3073921 tcctaatgtt aaacactatt aaaaacacta ctgacgttag cgattaaatt ctaaaaacct 3073981 gtttgtattc cttatatcga catatttctc gtatgtcttc actgatcatt aattatagca 3074041 taccgcctaa aaaaggttaa gtactcatga ggagaaaaac attccaaaat atgtaattac 3074101 actcagactc cattggcacc aaggtctgtt gttcattcgt tcattcaatt gtaaaattgg 3074161 aaacatattt aaatttaatg taaagataat gttaatcctt tgttgaagat ttatgttaaa 3074221 atataaggta gcttgatttt gcttttagaa actctcggtt tttaactata taaatagaat 3074281 cttaaaggaa ggaggagcca gacatgcaaa cagagactat tcacaatatt ccttatgtta 3074341 acagtaactt aacatcattt atcgattacc tagagaaaca ttatattgat caaaagattg 3074401 gtgctgtcat ttccacagtc aaccctgaaa ttgcatttgc agctattaaa gatcgggact 3074461 actttgatgt actatcttct tcaaacttca ttttgcctga tgggatcggt gtagtcatga 3074521 tgtcacgttt gactaacaac aggcttcagt cccgaatcgc aggttacgat gtttttaaag 3074581 aacttctggg cgttgctaac aaaaagaaaa aacgcatatt tctgtacggt gcgaagaaag 3074641 atgttataaa aggtgttgta tccaaaattt cttctgaata cccaaacatt aaaatcgcag 3074701 gttattcaga cggttatgtt caagatcgca ccctagtggc aaaacaaatt gcaagagcaa 3074761 atcctgacat ggtattcgta gctttagggt atcctcatca agagaaattc attcataact 3074821 acagacactt gttccctaaa gccgtatcta taggtctagg aggaagcttt gatgtattta 3074881 gcggtaatgt caaacgggcc ccttcctgga tgatacgttt aaatttagaa tggttctacc 3074941 ggttaatctt gaatccatgg cgatggaaaa gaatgcttag catcccaaaa tatgctttaa 3075001 cggttttaaa agaagaaaaa aacaaaaaaa ctttctatcc aaagcctgaa aaagatcata 3075061 caaaacagat ttaaaaacaa aactttcaaa taaatggatg ataaaaatga aaataagatc 3075121 actactggcg aattgctatt tgtatttttt atcagcaatc gccttttttc tgcaatgggt 3075181 gaaacctgaa agcaaagtga ccctcctgat ctcattcgaa gcaaacgcaa aagcgattct 3075241 tgaggaatat gaacaaggac aatactctta taaacttaac atcctgtata cccagcaggc 3075301 ctctgctatt gccgagagct tcccgaatgt agatgcatat ttattacaag aaaaaaaccc 3075361 tatccatctc attaaagctg tatacctaat gtttaacagt aaagtgatca taacagataa 3075421 ttactttcta ttaacaagtg tgttaaataa gcggaagcaa acgaaatgta tccaagtatg 3075481 gcacgcaaat ggctcactca aaaaatttgg tttggaagac attacaaaca tgcaacggac 3075541 gaaaactgat attaaaaggt tccaaaaagt atacagttcg tatgattatt taactgttgg 3075601 ctcagaagag atggcaaata tcttcaagaa atcatttgga ataaaggata accaattatt 3075661 aaaaataggt gtacctttaa cagaccctta ttaccgagaa aacaagaaaa aaatttcaga 3075721 tactctaaac atacaaagaa aaaaaataat cctctatgca ccgacgttta gagattataa 3075781 tatgcaatca attcaattgc cttttacaga agaacaatta attcatcagt taaaagaaga 3075841 atatgtttta tttgttaagc tgcatcccgc cattcagaac aatattgata ttaaatattc 3075901 cagtgattat attaaagatg tttctaacta tgccttgttt gatctactca tggctgcaga 3075961 catattaatc actgactatt cttctgttcc ctttgaattt tcgattttaa ataaacccat 3076021 tcttttttat acttacgatt taaaacttta tcaacagaag cggggattgg ttgataatta 3076081 tctttccata atacctggaa gagcctgcta tgacagtgaa tcattaataa atgaaattca 3076141 aaccccattt aattattcca aaataaaagt tttttccgat agatggaata agtattctga 3076201 tgggaattca agccaaaatt tattgaattt catcgaaaat ttaataagct aaatgatgac 3076261 acttgttcaa aacagaacaa gtgttctttt ttctattgaa taccgaacgt atgtttgctt 3076321 taatgtaatt agttgcttat ggcagcaaat aataatagag gtggtaaatt tatgagaaaa 3076381 aaagaactgt ttgatttcac caacatcacg ccaaaattat ttactgaact acgtgtagca 3076441 gacaaaaccg tacttcaatc attcaatttc gatgagaaaa accaccaaat ttatacaacc 3076501 caagtcgcaa gtggattagg aaaagacaac acccaaagct atcgcataac tcgtctatct 3076561 cttgaaggtt tacaattaga cagcatgctg ttgaaacatg gaggtcatgg tacaaatatt 3076621 ggaattgaaa accgtaatgg caccatttat atttggtctc tatacgataa accaaacgaa 3076681 acagataaaa gtgaattagt ttgtttccca tataaagcag gcgcgacttt agatgaaaat 3076741 tctaaagaac ttcagcgatt ctcgaatatg cctttcgatc atagggttac acctgctctt 3076801 gatatgaaga atagacagtt ggcaattaga caatacgata caaaaaataa taataataaa 3076861 cagtgggtga caatctttaa cctggacgat gcaatagcaa ataaaaacaa tcctctttat 3076921 actattaaca ttcctgacga acttcattat ttacaaggtt tctttttaga tgacggttat 3076981 ttatattggt atacaggaga tacaaacagc aaaagctatc cgaatctcat aactgtattt 3077041 gattccgata ataaaatagt gctgcaaaaa gaaattactg ttggcaaaga cttgtccacc 3077101 agatatgaga ataacttccg tgaaccggaa gggatctgta tgtacaccaa tcctgaaact 3077161 ggggcaaaat cattaatggt gggaattaca agtggaaaag aaggaaatcg tataagcaga 3077221 atttatgcat accattctta tgaaaacttc atgaatcatg tacctatgct tcgatcccct 3077281 ttattaaaaa ccgtggggca ccaagataca cctccagaaa gatttcaacc atttattcaa 3077341 accttcattt tagagtataa tgctcaaaac aaaaaatgga tggttccgac ttcaggttat 3077401 ttaccatctt acacatcaaa tttagtccga aatattacta tcaatgcaga tggaaacttg 3077461 caagtcacat taaatgaacg ctatattagt ttactgcatc aatcgataga aggagatttc 3077521 cgcttaaaac aaaaggatat ccgaatggga tcctggtatt ttgccggcgg agaaaaatca 3077581 aatgtgcttg aaataggttt tatgaaaggg agtacaaaaa tcagacccga tgatgcagcc 3077641 atctcaaatg cttcaagaat gagtattttt atgattgttg cggacaagat tgaggtgtga 3077701 taatcaaata ggctgtagct atttaatagc tacagcctat ttgcaacttt ctaagttttt 3077761 tatcgatatt ccggaacatc ggcctacttt atagaccagc ttctttcggg gcaatatgca 3077821 taaagaaaag actccagaga ttggagtctt tttcttttat tgcacccgta tacttcctgc 3077881 gtatttatcc ttccaatatg tgctcgtgtt catattggta atggtcacgc cgtttgataa 3077941 tgtgacatga acaacttgtc cgtttccgat atagatggag ggatttaagc ttgttgattg 3078001 aaagaacaca atgtctcccg gcttcaggtc cgccttctca atcttagttc cggcattgta 3078061 ctggcttgtt gcgtatcgag gcagggaaat accggctgct ttctggtata catattggac 3078121 aaatccagct gtatcaaatc ccgtctcagg tgttactccg ccctgtttgt aaggcacttc 3078181 tccgacataa agcgtcgctt cggaaacaat cggattttct ttcgggattg tcaggttgtc 3078241 aaatcggcga atacccgtca tcttcgattt ccagtaatcc tctgacaaat aggaaatggt 3078301 tactttttct gaccggcttg cctgaatgaa cctgcctgcg cccgcataaa tgcctgcatg 3078361 tgaaattccc gttttatacg tattgctgaa atagacgaca tcaccaggct ttatgttctg 3078421 aggggctacc ttctcgccca ctgcccactg ctgttcggct gatcgcggta gataaatgcc 3078481 gagtgcctgt tgaaacacat attgcacaag ccccgagcaa tcaaagccct ctgacggcgt 3078541 gcttccgcca aacacatatg ggacaccgat atatttttcg gcctcctgaa cgacaggaac 3078601 atcagccgtt gccggatcgg cagcgattcg tctcgccccg atataagttc cgctccaata 3078661 gctgcttttt ttgtaattgg tgatgataac cccttttgac tgtgtactgt gaaccatttg 3078721 gccgtctccg atataaaggg cgtcatgtgt cggaacagtg ccggtgcttc cctctttctt 3078781 gaaaaacaaa atatcacccg gcttcaggtt ttccggtttt acagctgttc cgattttata 3078841 ctggtcgttt acagatctcg gcagatgaat atcagcctta ctgaacacat attgtatcaa 3078901 tcctgatgga tcgaaaccct ctttcggcgt ttccccgcca tatttatact gatatccaag 3078961 caggtttttt gcttcgctga caatcaattc tgatgatgta tcagcttccg caatctccgc 3079021 ttttgtcata attggaacca aaaaacaaat gataaccgcc acaagcaaaa acttcttcca 3079081 gtttgccagt gtgttcactt ttattatctc ctcctctttt tgcagtttta acatcggtat 3079141 ttttttgaat atgttaagag actttttaat atttttacag aatgaatatg ctgggcaaat 3079201 aaaaagagag tgtctcatca gacactctct tttttgaatt atttattggc gtttaccggt 3079261 tcttcctgct gctggatttt attcatttcc atatcaatct tctgtttttc ctgatctgtc 3079321 agctgatcat tgaatttaaa agctgacata aacatgaaca cgatggctac ggcaacaaac 3079381 ggccagatgg ctttgacaaa tttcatcttt atcactccga ttatttagat tttagtttgt 3079441 cactatgatc aatatcaaac gtcagttttc cgtcttctac tttccaagcg aaattagagt 3079501 ctttcgtcag ttcgcgaata atggttttct gtttaaggct gtcttttttc acaggcgcag 3079561 gtgtcgcttc atggatatcg atcggtgtca cttcaaagcg tcctgttcca tttttcttca 3079621 ggtgatactg aaccagtgca ctgtctcttg ttctcgtcca gccttggtca aagacaaagt 3079681 tgccgaggct gtagaaaatg acggttccgt tatatacttc aatcggttct aagacgtgcg 3079741 ggtgatggcc gacgatgatg tcagctcccg catcagacat ggctcttgca agctggcgct 3079801 ggcggtcatt tggatcattg tcatactctt gtccccagtg tgactgcaca acaacaatgt 3079861 ccgcatgttt tttcgcttct gaaatcatag ggatgaagat ttcaggatct gcgggcagca 3079921 cgcccggcgt attcttttta gccgcgaaac ctttcccgga cacatcggta aagccaagcg 3079981 tcgcaatcgt taccccgttg actttctggt acgaaatttt ctttttcgca tcacttaagc 3080041 tgtatcccgc tccaacgata tcaagatttt gcttcgcaaa ttctccaagc gtatctttca 3080101 tgccctgaac gccgtaatcc attgcgtggt tgttggcgct gttgagaacc gtgaaattca 3080161 tatccttcaa gactttcact gattccttat tcgtctgcag atgaatctct ttatctgctt 3080221 gtttataatt cttttgatag gttaccgggt tttcaaagtt tcctgctaca taatccgagg 3080281 ctctaaagat cggttcaaca tattgaaaaa tactgtctgc ccctttttgc tccgttactt 3080341 tttcaacata gcgtcccatc ataatatcgc ctacaaatga ggctgagagt acgtcgtcag 3080401 aatacgtttt gaccttcggc gtttccgctt ttcccgccca catgaaagcg aacataagga 3080461 caaaaacgat cggaatggca ataaatacgt gcttattggt tttctttttt tgctgttttg 3080521 tcagctttag cagcttttca tgaaagctca gttctttttt catcgtttga cacaccttac 3080581 attaaattaa gtagtaaaca aacatgatag caaaggtcgc tccgctcaat agcagcgtgc 3080641 ttccgaacgt aatggttaaa ccttgtttct gaatggtatt ggcaattaaa cctggcacga 3080701 tgatgccgat tcctcgaaat tctgcgattt caaatggtac aatcgggtat agaaaatcaa 3080761 acgcgatttt taggacgatc cctgttatca gcatggcagc gaattttctg cgtccgtaca 3080821 aaatcataaa tttggataaa ccgtatttca caatgacata cgtgagcaag ctcactagca 3080881 aaacaagtaa aataaagacc ggctgattaa acacaagtcc taaatatccc ggtacaacaa 3080941 gtcctgccgg cacgatccct gttttttccg caaaaattaa actgagtagt acacctaaaa 3081001 ttagtgcgat gtataaatct gatccgaaca tgtctgcatt tccccctagc ttacgagctg 3081061 ctttaccttg tattcgtgga ttttttcaat taaaggctct gcggcaccat gaatattgcc 3081121 gacgccatat atgacacggt tgtgcattct tttctttaac aattccataa tttcatctgt 3081181 tgacttatac tctagatcat gcagtttgtc tgcaggaatt ttgccttctt cgtaggcttt 3081241 tacgatcggt tctgttgttt caccgattaa gatcagttca cttgcttcaa tataaggcaa 3081301 tacgtcattt gcgaattgct gtgtccgatc gacacggtct gcgcggcagt tcatgatgat 3081361 gatcggatca tcggtcgggt aaccgatttc ttttacacgt ttccatatat tcaaagtaga 3081421 agaagcgtcg tttgcggcaa acccattaac aaagtgccca ggctcgctcg gactgatcag 3081481 cggaagaatt ctcattgctc ccggatctgg cggcgcattc agcattccct taaatgctgt 3081541 ttcttcgtca atgccgagtg cttgagccac acccagcgcc agagaagcgt tatcagggaa 3081601 taccatgtat tcaaatttac gtaaatactc atctgtaatt tttgagttat cagcaatgat 3081661 gacttttgtg tttcgttctt ttgctttttg tttaaagaac tcggtatatt cactatctgt 3081721 aatgacaaga tggccattat aaggaattgt agcagtaaac gcttctgcaa tttcatcaag 3081781 cgtcggcccc atgacatcca tatggtcttc caaaacattc acaatgacgc cgatattggc 3081841 ctgcagaagt tcttcctgaa agatgatttg ataatctggg ttaacagcca tgcattcact 3081901 gacaatcgcg ttagcccctc tttctactgt ttctctcatg acttcttttt gctctccgat 3081961 attcggcccc tgaggtttcc gtttaatcgg cttttcctcc ggtgtgtccc agtaaatcat 3082021 tcttgcatct gttcctgttg tttttccaac agtcttgtaa ccggcttcta ttaatattcc 3082081 ggttgtcagc cttgtcacag tcgattttcc gcggatgccg ttaatattca cccgaacagg 3082141 gagggcatca atgtttttct gatgtcgtcg tttttctaat attccgatga ccagtatgac 3082201 agcacaggct ataatgagta accacattgc ttttcgacat ctccttctat attgttgtaa 3082261 attcattcat cagtatatag aatcactatg aattctcaat cggcattatg taacataatc 3082321 ttccctaatc gactaagcca aacttctctt ttgaaagaga ttttatacct acaaactgtt 3082381 ttctattttt ggaaaacagc aggacttata ccttatcact ttttaaaaaa atcaaagaga 3082441 atgcgctttc atttttctcc tgatatcctt ctggacgtat agtcacaccc tgctgtttgt 3082501 atttaatatg catttcaaat caatcttttt ttcagccttt gttatcaagc atttcctgct 3082561 atcatgcgtg tttccggttc ttatgaacac aaaataattt tatcctgttt cttaaggaca 3082621 aggtcataat gtcatccttt ctgcatggaa taagcaatat gaggcccatt ccaaaatgac 3082681 taaggaggtt cgagatgaaa acgctaaaca tacgagtccg aattctctaa cataattaaa 3082741 cattttctgg gatgatagtc ttttctgttt ctccccattt acaggtctaa acgcatgact 3082801 ttgaaacaat tttaataaaa cttaatattt gttcaagaaa tcttcatcca tatttgtgaa 3082861 gactttgtca aaaaaagagt gaaaacctta aatttttcaa ttatatatac aatttacaat 3082921 tagatttctt ttgatatttt tattgctaac ttcggattgt tcatgataat ctatctatgt 3082981 aaacggttac ataaacaagg aggagctgtt ttggctacaa ttaaagatgt cgccggagcg 3083041 gcgggcgttt cagttgcgac ggtttcccgc aacctgaatg ataacggcta tgtacacgaa 3083101 gaaacgcgaa cgcgtgtcat agcggcgatg gcgaagctga actattaccc gaatgaagtc 3083161 gccagatctc tatataaaag agaatcccga ctgatcggac ttttgctccc ggatatcaca 3083221 aaccctttct tcccccagct tgcccgcggt gcggaggatg aattgaaccg ggaaggctat 3083281 cgccttattt tcggcaacag tgacgaggaa ttgaaaaaag aacttgaata ccttcaaacc 3083341 tttaagcaaa atcatgtcgc aggcattatt gccgcaacga attacccgga tctcgaggaa 3083401 tacagcggca tgaattatcc agttgttttt ctggacagaa cgcttgaagg ggctccttct 3083461 gtgtccagtg acggctatac aggagtaaag ttagccgccc aggctatcat tcacggaaaa 3083521 agccagcgca ttacgctctt gagaggaccc gctcacctgc cgaccgctca agaccgattt 3083581 aacggcgctt tggaaatctt aaagcaggct gaagttgatt ttcaggtcat tgagacagct 3083641 tcattttcaa ttaaagatgc acaatcgatg gcgaaggagc tgtttgcctc ttatccagcg 3083701 acagatggtg tgatcgcgag taatgatatt caagccgctg ccgttttaca tgaagcattg 3083761 cggcgcggaa aaaacgtgcc ggaggacatt caaattatcg gctatgatga cattccgcaa 3083821 agcggacttc tgttcccgcc actttctaca attaaacagc ccgcatatga tatggggaaa 3083881 gaagctgcca aactgctttt gggtatcatt aaaaaacagc cgctggcaga aacggcaatt 3083941 caaatgcctg tcacctatat aggaagaaag acgacaagaa aggaagatta agatgcgtaa 3084001 tatttgtgtg attggtagct gttctatgga tttagtggtc acctcggaca aacgcccaaa 3084061 agccggtgaa acggttcttg gcacgtcatt tcagactgtg ccgggcggca aaggagcaaa 3084121 tcaggccgtt gccgcagcca gacttggggc gcaagtgttt atggtcggca aagttggaga 3084181 cgatcattat ggaacagcta ttttgaataa tctcaaagct aacggcgttc gcactgatta 3084241 tatggaaccg gttacacata cggaaagcgg aaccgctcat attgtgcttg ctgaaggcga 3084301 caacagcatt gtcgttgtca aaggcgcgaa cgatgacatc accccagcgt atgcgttaaa 3084361 cgcgctcgaa cagattgaaa aggtcgatat ggtgctgatt cagcaggaaa tcccagaaga 3084421 aacggttgat gaggtgtgca aatactgcca ttctcacgat atcccgatca tactaaaccc 3084481 agcaccggcc cgcccgctca agcaggaaac aattgatcac gctacctatc tgacgccgaa 3084541 tgaacacgag gcttcgattt tattccctga gcttaccatt tccgaagctc tggcgcttta 3084601 tccggcaaag ctctttatta cggaaggaaa acaaggcgtc cgctattcgg ctggcagcaa 3084661 agaggtgctc atcccgtcct tccctgtaga acccgttgat acaaccggag ccggtgatac 3084721 gtttaacgca gcatttgccg tggccctggc tgagggaaaa gacattgaag ccgcattgcg 3084781 gtttgccaat cgtgccgctt ccctttctgt ctgctccttc ggtgcccaag gcggaatgcc 3084841 gacaagaaat gaagtagagg agctgctgtc atgaaaaaac acggtatact gaacagccat 3084901 cttgccaaga ttttagccga ccttggccac actgataaaa ttgtcatcgc ggatgccgga 3084961 ctgccggttc ctgacggcgt tttgaaaatt gatctttcac tgaagccggg ccttccggct 3085021 ttccaagata cagcggcagt actggctgag gaaatggcgg tcgaaaaagt cattgctgca 3085081 gctgaaataa aagcatccaa tcaggagaat gcgaaatttc tagaaaatct tttctctgaa 3085141 caagagattg aatacctttc tcacgaggag tttaagctgc tgacaaaaga tgcaaaggca 3085201 gtcataagaa caggagaatt cacaccatat gccaactgca tcctgcaggc aggtgtactt 3085261 ttctagaaag gaagatgaaa catgcagatt gaaatgaaag acattcataa aacattcgga 3085321 aaaaatcagg tgctgtcagg cgtttccttt cagctcatgc ctggcgaggt tcacgcatta 3085381 atgggagaaa acggcgccgg caagtccacg cttatgaaca ttttgacagg cctgcacaaa 3085441 gcagataaag gtcaaatcag cataaacgga aacgaaacgt atttttccaa tccgaaagaa 3085501 gcggaacagc atggaatagc ctttatccat caggaattga atatctggcc ggaaatgacc 3085561 gttcttgaga atctatttat cggtaaagag atatcctcca agctgggcgt tttacaaaca 3085621 agaaaaatga aagcgctagc aaaagagcaa tttgacaaac tttccgtctc tctttctctt 3085681 gatcaagaag ccggcgaatg ttccgtcgga cagcagcaaa tgatcgaaat tgcaaaagcg 3085741 cttatgacaa atgccgaggt aatcattatg gatgaaccga ccgcagcgtt gactgaacgt 3085801 gaaatcagca agctctttga ggtcattaca gcgttaaaaa agaacggcgt ctccattgtc 3085861 tatatttcgc atcgcatgga agaaattttt gcgatttgcg acagaattac catcatgcgt 3085921 gacggaaaaa cggtagatac aacaaacatc tcagaaactg attttgatga agtcgtcaaa 3085981 aaaatggtcg gacgggagct gactgaacga tatccaaaac gcactccttc tctcggtgac 3086041 aaagtattcg aggtgaaaaa tgcttccgta aaagggagtt ttgaggacgt cagcttttat 3086101 gtgcgttccg gtgagatcgt cggtgtttca ggattaatgg gagccggccg gacagaaatg 3086161 atgagagcgc tgttcggcgt tgacaggctg gacacgggtg agatatggat cgctgggaaa 3086221 aaaacggcta ttaagaaccc gcaggaagcc gtgaaaaaag gtctcggctt tattacagag 3086281 aatcgcaagg atgaagggct cctgctcgac acctcgatcc gcgaaaatat tgccctgccc 3086341 aatctgtcca gcttctcacc aaagggtctc attgatcata agcgggaggc tgaatttgtc 3086401 gatctgttaa tcaagcgcct cactatcaaa acagcatcac cggaaacgca cgcacgccat 3086461 ttatcaggag gaaaccagca aaaagtggtg atagccaagt ggatcggcat cggaccgaaa 3086521 gtgcttatct tggatgagcc aaccagaggt gtggatgttg gcgccaaacg agagatttat 3086581 acgctgatga atgagctgac cgaacgcggt gtcgctatca tcatggtgtc atcagagctt 3086641 cctgaaattc tgggaatgag cgatcggatt atcgttgtcc atgaaggcag aatcagcggc 3086701 gaaatccatg cgcgagaagc aacacaagaa cgaattatga cacttgccac gggagggcgg 3086761 taatatgaaa acggaacaac tgcaaacaga acaaaaacgg attcacttcg acggagtcat 3086821 gcaaaaactc ggcccgtttc ttggtttatt tattctcgtt atcattgtat ctattttaaa 3086881 tcccagcttt cttgaaccgc tgaatatttt aaacctgctt cgccaggtcg ccattaacgg 3086941 attaatcgcg ttcgggatga cctttgttat tttgacaggc ggcattgatc tttctgttgg 3087001 cgctattctt gccctgtcca gtgctttagt tgcggggatg attgtgtccg gtgtcgatcc 3087061 ggttctcgcg atcatccttg gctgtatcat tggtgccgta ctaggcatga tcaacggatt 3087121 attgattact aaaggaaaaa tggcgccctt tatcgccacg cttgcgacca tgactgtgtt 3087181 tcgcggactg acgctagtgt atacagatgg aaatccgatt accggacttg gcacaaacta 3087241 cggttttcag atgttcggac gcggttactt tttaggcatt cctgtaccgg caattacgat 3087301 ggttcttgcc tttgtcatcc tttgggtgct tcttcataaa acaccattcg gacgccgaac 3087361 gtacgctatc ggcggcaacg aaaaagccgc gctcatttca ggcatcaaag tgacgcgcgt 3087421 gaaagtgatg atctattctt tagccgggct tttatccgct cttgcaggtg ccatattgac 3087481 ttcccgcctg cattcggccc agccgactgc gggagaatcg tacgaacttg atgctatcgc 3087541 ggcagtcgtc ttaggaggga caagtctttc cggcggccga ggacgcattg tcggcacgtt 3087601 aatcggggtg ctgatcatcg gcacacttaa taacggactt aatctgcttg gcgtctcatc 3087661 attttatcag ctggttgtca aagggattgt tatcttaatt gcggtattgt tagaccgcaa 3087721 gaagtcagct taggagggtt ttacatgaaa aaggctgtat ccgtcatttt aacgttatca 3087781 ttatttttgt taaccgcctg ttcgcttgag cctccccaat gggcaaagcc atcaaactcg 3087841 gggaacaaaa aggaattcac cattggcttg tccgtctcaa cgcttaataa tccttttttt 3087901 gtctcattaa aaaagggtat cgaaaaagaa gctaaaaaac ggggaatgaa agtcatcatt 3087961 gttgatgcac aaaatgattc atcgaaacag acgagtgacg tggaagattt aattcagcaa 3088021 ggtgttgatg cattattaat caacccgact gattcttcgg cgatctcaac ggcagtagaa 3088081 tctgcaaacg cagtcggtgt gcccgtcgta acaatcgatc gatctgcgga acaaggaaaa 3088141 gttgaaaccc tcgttgcttc cgataatgta aaaggcggtg aaatggccgc ggcgtttatt 3088201 gccgacaaac ttggaaaagg agcaaaggtg gcagagcttg aaggcgtccc cggcgcatct 3088261 gccacacggg aacgcggctc aggattccat aacatcgcag accaaaagct ccaagttgtc 3088321 acaaaacaat cagctgactt tgaccgcacg aaaggcctga ctgtcatgga aaacctgctg 3088381 cagggacatc ctgatatcca agctgttttt gctcacaacg atgaaatggc gctcggtgct 3088441 ctcgaggcaa ttaacagctc ggggaaagac atattggtga tcggttttga cggcaataaa 3088501 gatgcgctcg cttccattaa agacagaaag ctgtcagcca ccgtcgctca gcagcctgaa 3088561 ttaatcggta aattggctac agaagcagca gatgatattt tgcacgggaa aaaagtgcaa 3088621 aaaacaatat ccgcgcctct caaactagaa acacaaaaat aattgtctga tgtttaggaa 3088681 cctgcgataa cgtgaataga gatatagaat gaattatttc tcttacgtga ggagaggaac 3088741 ggcatgaaca aaccaacaaa actattttca acattagcac ttgcggctgg aatgactgcg 3088801 gcggctgctg gcggcgctgg cacgatccat gctcaacagc cagaaacaac ggtaagcatt 3088861 gatgatttat acagttatcc gattgattct tatttggtat cagcagaggc tctaaatgtc 3088921 agaacgaagc cttccgcatc aagccagaaa gccgatacgc tgcacttagg agatagccta 3088981 aagctgattt ccttctcaaa tgctgactgg gcaaaggtta agtataaaaa tggaaaaaca 3089041 ggatttgtat ccactcatta cattgttaaa gcagcgacaa cggtaaaaac caaaacaaaa 3089101 acaaaagtgt atacatccgc tgacggaaag agcattaaga ctcttccagc agacacaagc 3089161 gtttcttttt taggctggag taaaacgaat aaaggcggtt ttgattttga ttgggtattc 3089221 gttgattacg gcggtacgac aggttatatg aaaacaaagg atttacacat gacaaaataa 3089281 ctgagaggga ttccgcataa atgcggaatc ccttttatta tgaattgatt tgtcacattc 3089341 ccaagatatt tctcaggaaa tattgtcgta tgctgtgtcg aaaccttaca tgatcatcga 3089401 catttttgtt cacgctaaaa agcggaggtg taaatatgga tcaatttgaa gcagcatatg 3089461 aatcgtataa agcccggcaa acaactgccg atcaagaaaa tgttccatct ggaaaagaag 3089521 aaattattgc ggttagaaga aatgaggaag acaatattat cgcagtgaaa accaatacag 3089581 gaagagagct cgactaccct actgcgctgt cagaagcaaa atcaggaaaa ctcgctcatg 3089641 ttgatgtctt ccataaatac gggcgtgaca ttttgcgaag tgaaccggac ggcatcaagg 3089701 aaaataacct gtctgagctg ccggattttt aaacaaatac agccctgccg tatgttggac 3089761 agggctgtat tttaaacaaa aggctgctgg atgtattcgg ctaaccgttt tgcactgtga 3089821 gaaatatcct ctgcagctgc ataattcacg ccatagaaca catatggagg cagatacttc 3089881 atgccgatca gattactcgt ggcctgaaat ggtttcaata gctcactgat cgagtaatga 3089941 tttgctccgc ccgcttgata tttttccgct tcgctccctg ttgatacagc cagcatcagc 3090001 tccttgccat gcaaggcatt tccttctgaa ccaaaagccc agccataagt cagcacaaga 3090061 tcctgccatt ttttcaagag cggcggagag ctgtaccaat atagcgggaa ttgaaagaca 3090121 atccgatcgt attcctcgca cagctgctgt tccttcgcaa catctatcgc ttcatccggg 3090181 tattccttat aaagatcccg tactgtgata ttgtcatgtt tactcaattc ctcagcccac 3090241 gccttattaa caactgaggt ctccatatga ggatgcactg ccaaaaccaa tattttcatc 3090301 agaccacacc tttactgttt tgatgttatt ttatctaaaa tcaggaaaag agccaaataa 3090361 aaagaaagcc ctgctaaaag gggctttctt tttttctttt attcagggct tccttcagtt 3090421 gtttcgatat ctttcgcaaa atcagggtta tccagattcg cattaaagaa atccgctgtg 3090481 ttcggaagtc tgagattcat gttcattttt tgagaaatcg taaccgtgca atcctcaagc 3090541 acatagtcaa aaacgtgtcc gcctgaattg cgtccttcgt caatgaagtg caggtgatag 3090601 ccagaaacgg cgattccgtt tgcataagct ggtgtcaaga aacctacaat cgttcctctc 3090661 acgttgtcga agttgaaaat cggctgtgtt ttgaccgctt caaccattgg cacgtaaggt 3090721 ttttcttgaa gttctactgt tcttgtctgc acctttttaa acaatccgtc aatgcgaatt 3090781 gcataaaata agtttctgct tggcagcatg ctgttgatct ctttttcaaa gtcttcgcgt 3090841 gtcattttcg catcaatttt gtgcgtcatg tccggtgtaa agaacgtaaa tgaacagaac 3090901 ggtgaacggt ctccattttg gaccggtgtc gcggttccgt ctgagcgaag acggtaaaat 3090961 tcgccgtcaa acccaatcag ctctccgtca agcttgttaa aggttccgat accgaagtct 3091021 ccatatttcg gaatctctga cagttcaaaa tctccgtcat atactccgtc taatagagaa 3091081 gtcattgttg atacttgata aatctggctc acaggctgat ctttttgacc acggctgagc 3091141 acttgaatgt tgctttctcg tttcatattt cccttcactc cttttattta gtgctgttca 3091201 taaaacagtg tcgtgatgcg cagagtgcta gagagctttc gttttcatga gttccccgaa 3091261 ttctttcgga agcttgtcac ttgctaaatt aatgttatca ctgtagtcaa ccgggacatc 3091321 gatgatgaca ggaccttcag cgttcatgcc ttgacgcaga acatctgcca gctggtctgg 3091381 tgattctacg cgcaagccag ttgctccgaa gctttccgca tatttcacga tatcgatatt 3091441 tccgaaatcg accgcagatg tacggttata ttttttcaat tgctggaatg caaccatgtc 3091501 atatgtgctg tcgttccata caatgtgtac aattggtgct tttagtcgaa ctgctgtctc 3091561 taattccatt gctgagaata agaaaccgcc gtcaccagag acagaaacca ctttttctcc 3091621 cggtttcacc aatgaagcgc cgattgccca aggaagcgca acgccgagtg tttgcatacc 3091681 gttactgatc attaatgtta acggctcgta gctgcggaaa taacgtgaca tccaaatggc 3091741 gtgcgaaccg atatcgcaag ttactgtaac atgatcatcg actgcattac gcaactcttt 3091801 aacgatttca agagggtgcg ctctgtctga tttccaatct gcaggcacct gctcaccttc 3091861 atgcatatat tgttttaaat cagaaaggat tttctgctca cgctctgcaa attccacttt 3091921 cacagcatcg tgttcgatat gattgatcgt ggacggaatg tcaccgatca attcaagatc 3091981 aggctggtaa gcatgatcaa tgtcagcgat aatctcgtct aaatggataa ttgtccggtc 3092041 tccattgata ttccagaatt tcggatcata ttcaatcggg tcatagccga tcgtcagaac 3092101 aacatctgcc tgctctagca gtaaatcgcc aggctggttg cggaacaaac cgatacggcc 3092161 aaaatattga tcctctaaat ctctagaaag ggtaccggca gcttgatatg tttcaacaaa 3092221 tggaagctga acctttttca aaagcttgcg aaccgcttta attgcttccg gtcttccgcc 3092281 tttcatgccg accaaaacga caggaagttt tgctgtttgg atttttgcta tggccgcact 3092341 gattgcatca tctgctgcag gaccgagttt tggcgctgca acagcacgca cgtttttcgt 3092401 atttgtgact tcattcacaa catcttgcgg aaagctcaca aaagcggccc cagcctgccc 3092461 tgctgacgct atcctaaatg catttgtaac agcttccggt atatttttta catcttgaac 3092521 ttctacactg tattttgtaa tcggctggaa tagcgccgca ttatccaaag attgatgtgt 3092581 ccgttttaaa cgatctgcac ggatcacgtt tccagcaagc gcaacgacag ggtctccttc 3092641 agtgttcgct gtcagcaggc ctgttgccaa gttagaggca cccggtcctg atgtgactaa 3092701 cacgactccc ggttttccag ttaaacggcc gactgcttgg gccatgaatg ctgcgttttg 3092761 ttcgtgccgg gcaacgataa tttcaggtcc tttatcttgt aaagcgtcaa ataccgcatc 3092821 aatttttgca cctggaatgc caaatacatg tgtgacacct tgctccacta agcaatcaac 3092881 aacaagctcc gcccctctgt ttttcacaag ggatttttgt tcttttgttg cttttgtcaa 3092941 caccctcact ccttattatg cattttaaac gtaaaatttt aaatatcttg tgataagttt 3093001 cactatacac tctttggaaa ttgacctcca atatcgattc gccttatgat taatatgtaa 3093061 tacgaattat taacctatgg aaaggaatgc atattgaatg gagcttcgcc atcttcaata 3093121 ctttatcgca gtagccgaag agcttcattt cggaaaggct gcccggcggc tgaacatgac 3093181 gcagcctcct ctcagccagc agatcaaaca gctggaggaa gaagtcggag ttacgcttct 3093241 gaaaaggaca aaacgatttg tcgagcttac cgcagcagga gaaatctttt taaatcattg 3093301 ccgcatggca ttgatgcaaa tcggacaagg aattgaactg gcacagcgga cggcccgcgg 3093361 cgagcaaggc cttctcgtaa tcggttttgt cggatcagct acatatgaat ttctgccgcc 3093421 gattgtccgg gaatatcgta aaaaattccc atctgtgaaa atagaactgc gtgaaatatc 3093481 ctcgtctagg cagcaggagg agctactaaa gggcaacatt gatattggta tacttcatcc 3093541 tcccttacag catacagctt tacatatcga aaccgcccaa agcagccctt gtgttttagc 3093601 tttgcctaag caacacccat tgacttctaa ggaatcaatt acgattgagg atttaagaga 3093661 tgaaccaatt attactgttg ctaaagaagc atggcctact ctatacatgg attttattca 3093721 gttctgtgaa caagcgggct tcagacccaa cattgtccag gaagccacag aatatcaaat 3093781 ggtgattggt ttagtcagtg ccggaattgg tatgacattt gttccttcct cggccaaaaa 3093841 attatttaat ttggatgtta cttatcgaaa aatggaccaa atacagctta atgcagaatg 3093901 ggttatcgct taccgcaaag acaatcataa tccgcttata aagcatttta ttcatatttc 3093961 aaattgtcag cagacaagaa ctaaagagag tgatgcaggt acatgaacaa tacttgcaat 3094021 ctcttttttc ttttgggatt cttatggaat ttttattaat ttaatataat cgcttagtac 3094081 aactttatat cagtatacgt atacatacag tacaaatagt tggcaaggac atcagtaagc 3094141 gcaggacatt agtttgattt taaaaatgaa agatagagag gtgaagtaaa ttattgagtt 3094201 caccggcata ttcacattgc tcgctttttt cgtaacaatg atttttattt tctggagacc 3094261 aaaaggacta aatgaagcta tccccgccac atttggcgct ttaatggttt tattgtgcgg 3094321 aagtgtgtca ttggcagact taggggaaat cggaacaaaa gtcacgggtg catcggttac 3094381 aatccttgcc actatgatta tggccattgc actagaaagc tttggtttct tttattgggt 3094441 ggctgcaaaa ctgctccaac aatccaaggg ttcaggcatc aagctttttt ggctaaccaa 3094501 tttgctctgc tttctcatga ccattttcct taataatgat gggagcattt tgatcacaac 3094561 tccaatcctt ttgcttgtac taaaatattt aggtttaaaa aaacatcaaa aagccccata 3094621 tttattaagc ggtgttttaa tagccacagc ctctagcgca ccgattggcg taagtaatat 3094681 tgttaattta atttctctca aaatcattgg aatggatcta tatcttcaca ccgccatgat 3094741 gtttgtccct agtatgatgg gactcatttt tatgacttgt ctactgttta tgttctttta 3094801 taaacgtctt cccaaaagcc tgccagatat accgggccat tttcagtctc tgcggcatag 3094861 aaggtaccat cctcttcatt cgccatcagc tcctttacca gaacgaaatc aaacaaaaat 3094921 catgttgttt gtgcttgcat ttgtttttct cgtcagaatg agtctatttg cagcatcata 3094981 taccggtatt tctgttcctc tagtcgctgt catcggatct tttatcctgt tgagctggag 3095041 atggatttat ttcaaaacct ccccaagaga cttgttatat aaatcgcctt ggcacatttt 3095101 tatattcgct tttactatgt atgtcttaat ttatggtctg cataatattg gattcacaga 3095161 gttacttgtg agttattttg aacctgtggt ttctggaagc ctcgcccatg caactttcgc 3095221 atcaggtatc tctacttcag ttttttctaa tctctttaac aaccatccag cgttaatgat 3095281 cagtactttt accttaactg aaatgaccct gaatccttca acaacaaaaa tcatctactt 3095341 ggcaaatatt atcggcagtg atatcggttc attattatta cctatgggaa ccttagcaac 3095401 gcttatttgg atgcatatat taaaacagca tgatgaaagt atttcatggg gcgaatatat 3095461 aaaaacgacc attatcatca ttccgctgac tgttcttttt acgttaacat gtttatattt 3095521 ttggatcagt tggttatttc tttagcacag tatgaaacga aaaactgcct tctgcttttc 3095581 aagagggcag ttttgtatac actagggaag atgcattgtc tttagatgat ttaacttcca 3095641 aatgactggc tctccacttg cgttaataag ctcaatgata ttattagaga caccctttaa 3095701 tagtccgact ttttctggca cctctcccat atcaaatatg accaattcac caatattttt 3095761 tttgatctgc tcctcaaaat tacgcacaag aggaactttg gaaggcacga ccggcaattg 3095821 tgagttgtca agagtatacg gtgtttgttc agttgaataa ggggtaaacc attttaaatg 3095881 atgcatagat ataaaaagta ttttaaatac gggtgagaaa aatacaatat aatcgtttaa 3095941 aacatttgta acatatccat ggatcgatcg acccccagtt acataaactt caataaactg 3096001 gcctttgacc ttgtttaatg tatttctata tgaaaaagct tgagtttctg cctctatcat 3096061 tggatcttcc ggattgatca aaaatggctt ctcagtactg gtcactattt tcgccttgtt 3096121 tatttgatga agatgcaaca agggaatata aagataattg cagccatcaa aaataacaaa 3096181 aatatcctgt ccgatatcta tgagggtgcc gacaaacctt gtatctcctg aaatgacaac 3096241 ctcaacatct gtgttaagga attgattcaa acctttcacg attctcctcc tttaactgaa 3096301 aaagggcatc actttatctg atgctcctcc attatctatt aaaatttacg tttccagtga 3096361 tagtctatcg ttctgacaat cgtttcatag ctataatctt ccttttgttt tcctgaactt 3096421 tttattgaac ttgaatagcc tggtgatctt gatgattgat aatctgaaga tcttggtgat 3096481 cgtttagatg attttgatga ttgataatct gaagatttta atgatcgttt agatgatttt 3096541 gaagaacttt ttgaacgtga cgaacggcca gatttggatg attgataatc cgaagatttt 3096601 agtgatcgtt tagatgattt tgaagaactt tttgaacgtg acgaacgacc agatttggat 3096661 gattgatcat ctgaagattt tagtgatcgt ttagatgatt ttgatgagct atatgatttt 3096721 gaagaaatga acgaattgct gtccttatca ttattgtctt cctggttttg ttcatttttt 3096781 tgatcctctt ttttgtacga cccttttgga cctaagctga tgctttttat gtgaaaagga 3096841 tagatgcgaa gcacctcttg atttttcact atagtataat ggccgtcggc attatctaca 3096901 aggataccct caatggcttc cggacctcca cgattaattg aaacccattt atgagtcaga 3096961 ctcttaaaaa cctcgcttaa atcatcagct tccaaaactc caactggcgt ctgctcttct 3097021 attttcaaat caggctcgtg tttacttata cttttgatgt gatggatatt aaaatacact 3097081 accccatcct catttgtgtt taacgcagcg taatcatctc ccagccagac caatcttcct 3097141 tttttagatt ccggaccccc ttggttaaat tgaactgatt ggtttattaa atgtccgatt 3097201 aagctatgaa aatcatcagc atcgagcatt tcctcagtct caattgttgt ggtgctatta 3097261 ttggtatcct cagtaatact tttcacatgc tccaactgat aataaattat ttttttttca 3097321 gcttgtaaag ctatataatc tgattttaca gctgttaatt ttcctttttt agattccgga 3097381 cctccacgat atacagtaac aattttatct ttcattgagt gcaaaaagtt ataatacgat 3097441 atttcattat ttgaatgata tttcattctc ctcttgctca ttcaaattcc tcctagtcac 3097501 ttatacatag atgataaaca tactgcatat atacgtgtca catttatttg ttgaactaat 3097561 tcaatagcct aattgtcgct ttttccgcga atacccattt tcacgcattc ataaaatact 3097621 taaatgatct ttgaggtatt gtgaacggtt tttaatatac tcgcagatca catccggctc 3097681 acggtcaaaa cgctcaatat cattcttttt atacgggtcc atgaggacaa acggcctaat 3097741 ccgttcatac atcgccatga ttttcggttc catatattct attgtaaaaa gagattggag 3097801 cgttttttct aacaggcgct tgtaggactt gcgaaactcg gattcatcca atatccgggc 3097861 ggttagtgta ttaaatcctt gaattcttac ataatcggca gccatccgct ctccatggat 3097921 atccctgccc caagtcgcat cataatccca aggaatcacc tcaaataatc cggtttcccc 3097981 gcttctgtat aatgcgtagt tgtggacaaa cccgtcatag ttcgaggtga atacaatacc 3098041 agcaagccag cgcaaatact tatcgacatc cacgtgtttt gtcacttctg acttaaactg 3098101 agctttaggg accgtattaa ttttaaaaat catatcttgt aaataaaaat catcttcctc 3098161 agtccctgtt ttcttttcat atccaagctc cagcgatgtt ttcgtttccc tttctaaatc 3098221 gctcatcaga gaaaagttgg catcatcatc caccgcataa aaaatcgcgc catcagccag 3098281 cttccttttc gccaaataat attcatctac ggattcaagt tcaagataaa ccccttcatt 3098341 cttcccattc atctttacaa acgcaaactc tgcctttgga gacagtgtcc ctagctccga 3098401 gaaaaaatcc agagacaatt tgtttctcat caaggaaggg tctttatact ccgcatttaa 3098461 gtgaatctct cgcgcgccgc ggaatgtttt cggctgataa aaggaaatat ggtatgactt 3098521 ctttttgaag tctctgatat gtgatccccg ataagcgata tcaatatcca gccttttttg 3098581 atttaccttc atcacagctg gcaccggatc atcgtcccat atatcctttt ttaattcacg 3098641 caagtctttt ggatgaacaa acagctgata aagcggtaaa ttggattgat tcttcatcca 3098701 taatcctcct tacaaatttt aggcttttat ttttataaga tctcagcgga acacttatac 3098761 actttttaaa accgcgcgta ctatgagggt agtaaggatc ttcatcctta acatattttt 3098821 aaaaggagga tttcaaattg ggccactatt cccattctga catcgaagaa gcggtgaaat 3098881 ccgcaaaaaa agaaggttta aaggattatt tataccaaga gcctcatgga aaaaaacgca 3098941 gtcataaaaa gtcgcaccgc actcacaaaa aatctcgcag ccataaaaaa tcatactgct 3099001 ctcacaaaaa atctcgcagt cacaaaaaat cattctgttc tcacaaaaaa tctcgcagcc 3099061 acaaaaaatc atactgctct cacaagaaat ctcgcagcca caaaaaatcg taccgttctc 3099121 acaaaaaatc tcgcagctat aaaaaatctt accgttctta caaaaaatct cgtagctata 3099181 aaaaatcttg ccgttcttac aaaaaatctc gcagctacaa aaagtcttac tgttctcaca 3099241 agaaaaaatc tcgcagctat aagaagtcat gccgcacaca caaaaaatct tatcgttccc 3099301 ataagaaata ctacaaaaaa ccgcaccacc actgcgacga ctacaaaaga cacgatgatt 3099361 atgacagcaa aaaagaatac tggaaagacg gcaattgctg ggtagtcaaa aagaaataca 3099421 aataatctaa gttttcattg tttcaatagg ctgccggcgg aggtacggaa gcctattttt 3099481 ttatttgccc tgtattagat atatgtcatg acataacata tgcaacccgc atcatttggt 3099541 ttcctttaaa ccatttcgtt ataatcaagg tatcctaacg ataaaggcgg ttgttgctat 3099601 gtacatattt caagctgatc agcttagtgc caaagacaca tacaagctat tgtcaggtac 3099661 cgttattccc cgccccattg catttgtgac aacactttct tcaggaggag cggtaaatgc 3099721 cgcgcctttc agtttttata acgtcgtcag ctcagatcct ccgcttctca gtatttctgt 3099781 taacaggacg gaaggacgcc aaaaagatac agcacgaaac gcagtggaga acggagaatt 3099841 tgtcgttcat gtcagtgatg aagccatcat tgaagatatc aatgaaacag ctgcaagctt 3099901 aaggccggat gaaagcgagc ttacacgcac ctcgcttcat cctgttgaaa gcaaagctgt 3099961 ttcagttccc ggcattaagg aagcccgcgt tcgctttgag tgcaaattag agcggcatat 3100021 tacctttgac aatgatcaag gcatcactac agcagatctg ctcatcggaa gagttgtctg 3100081 cttccaccta gatgaaaagg tgtatgatgc agaaaaggga tatattttaa cggatgaatt 3100141 aaagcctgcc tcacgattgg cgggaaatca ctatgccaag ctgggggaag aattcacact 3100201 gattcgtccc agctgaagag aaggactatt taaatagaag aaactagtca aaaagacctt 3100261 atgattacaa aatatcgcct gtaaataact gaaaaaatat caaaaaaaag aacacccaga 3100321 gcaagctcgg ggtgttcttt tatgaaacgt ttttcctttt tcttcgtata aaggtagatt 3100381 aggaggaatt ggaatgacaa acttttggat tttaatgctg atcgctatta ccatcagtct 3100441 cgcctctcaa ttttttataa agaaaaaata cggtattgat aaatccggct ggcgatataa 3100501 gcatgtcagc aatacacaca aatggatcga aatcacttta cttattttgt ttgtgttttc 3100561 actctccttt tttccagttg aatatttgct tcttttattt tttattgtga ttgactcaat 3100621 acgtattttt atggagtggc attatagacc tgaagataaa cagtatatgt accacattgt 3100681 agaggtctcc cttatgttta tgcttttgat ttatgtttgt accctatagt tatttaaatc 3100741 cccacagccg ctccgtctcc ccgaggatcg gctccgcctt ggagaaagcc ttcttcatca 3100801 actttgattg cagccgcttg tcccatcagc ggatcatagt caccgacaac ctccacgaga 3100861 tgcccgctgt ctttcagttt ttggattgtt ttgtctgtga atctgccctc gactctgaga 3100921 ccttcgtatt cctctcccca cgttctgccc catacccagc gcggttcgct gattgcctgc 3100981 tgtggatgca ttccgtagtc cagcattcgg gtaatgatgg ccgtctgggt ctgcggctgg 3101041 ccttcgccgc cttgtgtgcc gtacagaatt tttggctttc cgcctttaca gaccatagcc 3101101 ggcatcaacg tatggaaggt gcgctttctc ggttcaagcg tgttgacatg attttcatcc 3101161 agtgagaaaa acgatccgcg gttttgcagt aatatgcctg tatcaccggc agtgactgcc 3101221 gagccaaatt caaagtacag gctttgaatg aatgacactg cgttgccatc cgcatcgatt 3101281 acggccgcat atgccgtatc acttcccacc ggcctgcttt ctgccggtat tgcgagatag 3101341 ccgatttctt ctgccaattg ttttgcataa cgtttgtcca aaagcctttc aagcggaatg 3101401 tctgcaaacg ccggatcagt caggacggca tcccgatcta gaaaactctt tttcaatgcc 3101461 tccacaagca cgtgataata ctcaaatgaa ccgtgttcga tttgggtgaa atcatagttt 3101521 tccaaaatgt tcagtgttaa taaaccggta aatccctgag aattcggcgg cgcctgatac 3101581 acactgtatc ctcgataatc acttgataca ggcgctgccc actcaccccg atgcgcttta 3101641 aaatcatcga ttgtcatgta actgccgtta ttctgtaaat gtgagacaat ccgctgagcg 3101701 agatctcctt cataaaatgc gcttcttcct ttttcagcaa tcaagttcag actgtctgca 3101761 agctcttttt gcacaaaccg ctctcccggg acaggtgctt tgccccttct cgtgaagatg 3101821 tcagccgtgt aaggcgtgga agccagcagt tcaatattct tttctgtgtg acgacactga 3101881 tcagctgata caggaaaccc attttgggca taatcgcgtg cgggctccaa tacatctgca 3101941 agagacagac gcccgtactc cttcaggacc gcatcccagc tatcaaccat tcccggcacg 3102001 gtaatagcac tgtcaattcc ccgcagcgga atcgcgcttt ttcccttata tacatctctc 3102061 gttacgtttt ttcctgaacg gccgctgcca ttgtagactt ttactgcctt tgtttcctgg 3102121 tgaaaggtca gccaaaagga atccccgcca agtccggtca tatgcgggta cacaaccgca 3102181 agacaagcac tcaccgcaac agcggcgtca aacgcgttgc ctcccttatc cagtatgcgg 3102241 tttccggctt gagaagcgag ataatgcgga ctgacgacca tttgctttgt accgatgaca 3102301 gatttgttca tcacaagtcc ccttttttaa gaaattttct tcagtatagg gagcctgatt 3102361 tttcacatct actgatccgg cagaaaaact gacgaacttt cttcttttcg caaataataa 3102421 gatattttcg cattcatttc gaaaacaaat gaaaaattat tatttctata cgtaactttt 3102481 atgataaaat gattgctaaa aggctacgaa agcaggtgga gcaattgagt catgaatatc 3102541 aaatccccaa ccttgtactt gatgagactg ataaacaaat tctcacgatt ttgcatgaag 3102601 aaggcagaat ttcttatacg gatcttggca aaagagtcga tttgtcacgg gtcgccgttc 3102661 aggcccgtat caaccaatta attgaagccg gtgttattga aaaattcacc gctgtcatca 3102721 atcccgctaa aatcggcatc catgtttccg tgtttttcaa tgtcgaggta gaaccgcaat 3102781 ttttagaaga ggtcgctctt aagcttgagg aagagcctgc ggtcaccagc ctttatcaca 3102841 tgacaggccc gagcaagctg catatgcatg ggatctttac caacgatcaa gaaatggaag 3102901 aattcttaac aaaacggctg tatccattgc gaggcgtcgt cagtgttgat tgccagatgc 3102961 tgatcaaacg atacaaaagc cgtatgggaa tgaagctgta aaggagagaa acaaatgaaa 3103021 aaccatcctt atcgggatat gacggccgca atggttcgca ccggcatatt agggttcggc 3103081 ggcggacctt ccgtgattcc gctgatccgc catgaagcgg tcaataaata taaatggatt 3103141 gacgatgatg aattcggaga aatattagca atcgctaatg cgcttcccgg accgattgcc 3103201 accaaaatgg ctgcttatct gggctttaag ctaaaaggca cattaggtgc aattgtggcg 3103261 atcctcgccc acattctgcc tacatgtctt gcgatggtgg gcttgtttgc ggctgtaaat 3103321 gtgttaagcc attcagcaat tgttgcaggt atgattggtg ccgtcacgcc ggtaattgcg 3103381 gtcatgctcg gaatcatggc gtacgagttt ggccaaaaag cgcttaaagg tttcggctgg 3103441 gttaccggca tcctgttttt tatcatcgct tttatcggcc tgcaaacttt acagattaat 3103501 cccggcctgg tcattatcat tttcttagct tacggggcgt ttcattttaa actgaaagac 3103561 aaaatcacaa ataaacattc aaaagataaa ggaatgtcag cctcatgata tcgatctatt 3103621 tatttatggc gttttttatc gcaaacctac tgggatatgg cggcggacct gcgtctatcc 3103681 cgctaatgtt tgaagaagtc gtaaacagat acagctggct ctcaaacgat caattctcaa 3103741 atatgctcgc acttgcgaac gcattgccgg gcccgatcgc cacgaaaatc gctgcgtatg 3103801 tcggctacag cgcaggcggg tggcccggct tcctaattgc cctgatcgca accgtcgtac 3103861 cgtcggcgct cgcattgatc gtcctgctgc gcatcatcca gcgcttccgc caatcacctg 3103921 tcatcaaagg catgacgctg tccgtccagc ctgtcatcgc ggtcatgatg ctcattctta 3103981 cctggcaaat cggcgcagac ggcatcaaag cgatcggctg ggtccaatcg atcgtgatta 3104041 cgggaatttc gctccttgcc atgacaaaat tcaaaatgca tccggcattt ttgattattg 3104101 cggcgttttt atatgggggc cttgtgatcc cttatttata gaaaaaagca cctggacagg 3104161 tgctttttta ttttagccca gaaatgccgt ttgatatgac agctgtttct tctcctgcgt 3104221 cactcttgat catgtgcttg acttgcagcg tggttcctgc cattctcaca gattgcttca 3104281 actgggacga attggtttca acttgtatcc aaacaggagg ctggaccttc caaaataaat 3104341 agagtgcaag aatcagcaag ccagcaatga ccgacagcaa aaacttcata tcgcatcgct 3104401 tcttttcagt aagcggctcg cagcggacag cgcctgatga tcacgaagaa tatcgcctgg 3104461 acgattgcct tctcccagca catagccttt aaaggacatt cccataaaat gaaaaatatg 3104521 ttcgaattgc tgaatcagcg gcagcccttt tatttttgga ttgtctccgc ccactgctat 3104581 tacatatgcc tgtttcactg acatttgctg tttaaaatca ggaaatctcg gatctctcaa 3104641 cgtctgtgac cagcgatcaa taaacagctt taatgtccct gacatgccaa accaataaat 3104701 tggggtggcg aatataagaa tatggcactg caatatccgt tcaatgatag aatcgtagtc 3104761 atcttgaaca ggacgaaagc cgccttgggc gtgacgcaga tcttcaattg gttgaattgg 3104821 atatttctgc aaataaatgt gctccgcatc gaatccttga acagccttct ccgcaagaac 3104881 atccgtattt ccgccagacc gagttccgcc gttaataacc gcaattttca tgatgcatct 3104941 gctcctttgt ttacgaatga ttttcttcat catataatgg attcatcaat caatacagat 3105001 gattatttcg attaatccaa tcgctaaaac cgatttagaa aggaagagaa caagtggaat 3105061 tgaagcagct gatcaccttt attacggcgg ctgaacatgt aaacttcacc ctaaccgcca 3105121 aaatgcttaa ttatgcacaa tcaagcgtta cctctcagat caaatcactt gaagaagaaa 3105181 tcggaacgcc tttatttgaa cggctcggca agcggcttat cttgacagaa gcaggaaaaa 3105241 cgttcaaatc ttatgcacag aagatcattg cgttaacaga agaagcgaaa atggccacaa 3105301 atcaagtaag agaaacaacc ggaaccttaa aaatcggggc gacggaaagc cagtgcacat 3105361 accgcctgcc ccctatcata aaagaattta aacaggcttt tccccaagta aagctcatat 3105421 tcaaaccata tatctccaat gaacaagcga aagaacagct cttacagggc cagcttgata 3105481 tcaccttcat cttggatgta aaccggatgg aagacgcact gcacgttgaa tctttgattc 3105541 aggatgagat caaaatggtg gctgctaatg accatccttt tcctgcggat ttaccagtaa 3105601 cattgaagga tcttcaaaac gaaactcttc tgctgacaga ggacggctgc tcgtaccgca 3105661 cgctctttga gaacaatttg catgactccg gtatctatcc taacaaattg gaattcgtca 3105721 gcatagaagc catcaaacaa tgcgtgatgg ccggacttgg gattggaatc ttgcctgaaa 3105781 tgacagtaaa agatgatatt gcagcaggcc ggatgaaaga actcaattgg cagagcgatt 3105841 gccccgtttt cactcaatta gcatggcata aggacaagtg gatgtctgcg ccattaaagg 3105901 cttttatcga tttgacacgg aaaacattca aataaaacct ctccacaagg acgacaaggt 3105961 ttttgagacc agggcacaca catacaaaaa aaacacttga tgacttagag ccccaagtgt 3106021 tacacgtgat ttttctgata aaacgttcgc aaaacatgcg tctcaaggtc agccaggcgg 3106081 acagggatcg gcagcctgct ttcttgattg atcaagctca tcgtgatctg atagctgctg 3106141 tctaaatcaa tataattacc gcaagacaag aaaataggct tcacgtcccg ccgcgttcgc 3106201 agcgcccgtc catatacctc gccgtcaatg ataatatcgg tgtatgcgcc tacttcaatt 3106261 tcaggcgtca cgaaatcgca gcctttgatt ttgagatagg ttttcgctat cccaatcgtc 3106321 ggcttgccca gaaaaaaagc cgcatgggtg gcaacgccca tatgattgta atgcagatat 3106381 ccgttgccat caaacaagaa gacatccggc tccgtctcca gctttttcgc cgcctcgatg 3106441 atcaagggca gctcgcgaaa cgcaagaaaa ccggaaacat acggcacgct gattctcccc 3106501 atgctgtgca ctttttcaat gacttctttt gtatcagcgt caattacgat aatacagcac 3106561 actccgtatg gttctccatc ctgctcccaa taggccaggt cgacgcctgc gcaggtgttg 3106621 atggagtctg gatggatcgt gggggatagg ttgatacgat ttttaaggtt aaattgcact 3106681 tgtaaaaagt cttgttcctt tttcatatca aatttatgca catcaaatac cttcataacg 3106741 attgctcact ctcgacctaa attaatgtga gtctctcttc tcgattctag tatttcaaaa 3106801 tgaggactat ctgtatctat ctcgtactta tttaatagat tgccttcttc atcccaattc 3106861 ttttcagaaa ttagtatgga atgctcatac tgttgctcac tttttttcct gccattttca 3106921 aaccaaatta tgcttatacc gtgcaattgc ccatatcggt attctttttc acttttttta 3106981 ttcccgtttt cataaaattc acatgttaaa ccatgggcca gaccattctt atatttagta 3107041 aaatagatga tttgaccatt tggatataat tcgtaagcca gccctgtaaa cggctggcca 3107101 ttttcgtctt caggattatc taaaatctca tcacttaccg aagagaacca taaatcctca 3107161 aagtccactc ccttttcttt tatactcttc atatcatatt cattttccat actttaaagc 3107221 ctccggtata taatttgtat tttgagttat atattcacaa tgtggacatc taggcattgg 3107281 gacaccttct ggcatctttt tatttatttt cctagcactt actacatata ccattaaatc 3107341 ttttaaatcc gcatcaggtc tttgaagtaa cgcttcattt agagcattaa cttcggcatg 3107401 agaacccgcc cctgacgtct ttatataacc ttctttaagt tctgtaggca tatttacaat 3107461 tctatcatga ataagtggat gtagtacctt aggtggcttc ccatctatat tgtttattcc 3107521 aaaataataa ttgcctgttt ttttgtccaa tacaccagct accgcagggc ctctttgttt 3107581 tttagttaga ccagaagatt taattctact aagttcgttt agtacttctg cccttagatt 3107641 tattcgatgg tgaagatctt ctttagacaa tacaccatgc ttatttctta aatattgaag 3107701 cctagtttgt ttttcttcag tagtcttagc aatattgcta ataaggcttt cattactcac 3107761 tttattgaca tatggagcat ttttttggta caaccgatca aagtagtgtg ccaatcctgc 3107821 tccaccaata atagtaatag cttccagcgc cccttgcttc cgcttctcct cagacacttt 3107881 gtttccgaac atatcccggc ctgtgacagc ttctgagaat ccgtttgacg caacaaggcc 3107941 gtatgcgccc atttctgtca ttttgagaat gtctaaggat ttgcctgttt tgtaggcgtc 3108001 taatgcgtgt tcagcagcga tagctgcttt tccggttttg tagatggctt ttccgccttt 3108061 gaaggcccgg cctgcccagc cgacgactgg tatgaatccg gcagcggcca tagctcctgc 3108121 tgtcacacgc tccgcggtgg agagtttttc tccggtaacc ggatcaacgc cttcggttgc 3108181 tcttttataa tcataatagc cagtgacttc tccagtaaag ttgcaaactc catcccatgt 3108241 tttttcgtac cacggtttgt ttgcttcttc ctcggctttt tcctggagcc gtcttgcttc 3108301 tgcttgctgg gtttttgcat cgatataggt tgttccttga ttttctactt caatgacgct 3108361 tttgtagact tcattgctgt ggaaggcttt tttgtcatag tacatagggg atgcgctctt 3108421 cccattgctg gtggcctgca tgagaacaga atatttggtg agcactgcgt tgtccagaga 3108481 ttctaaattt tgatattcag tggtcaggga ttcatcaagc ttatcgacag ctgtgattgt 3108541 atcacgtctg attttttggg catcgcccat cttatctgca tagtcgtcaa gcgtgtacat 3108601 gtcgagatca ataatatcgc tgatgcctga caaaatagaa tcgatttctt ctttatgagc 3108661 ggagacaatc tctgaggctt tcaggtctcc attgggcagc tcatgatcca aaaaagaagt 3108721 ttccacatat gaatcattca gttcttgatc tttaatatct cctgaaatgc cgtttaaaaa 3108781 cgcaatttga gcagagacaa gcgtcagcca gctgtctacg atttctgcct gtccctgaaa 3108841 aaaatcttta atattgtccg cgccatttcc tttaaaatta tcgcctaaat cggcaactcc 3108901 ctgaaacgct tttttcagcg tattcagctg ctcttcaagc gtctcatatt gcttttttct 3108961 gctcttcgct tcttcgatta aagattttga ttcaaatact ttactcatcg cactgccctt 3109021 tctgttctat tttaccgcta tcgcctcgtc ctgctctttg agtgaatcta cgttatcctt 3109081 tgtatcctcg atatttttct gtaccgcttt tttgtaatct ccgagcatgg ttttgatgtt 3109141 ctcctcacgc tcatggtatt ttttcgtata atcgaggctg ttttttccgt tggatcctgc 3109201 ggcgccgatt gatacgtcag caagcgcatc tttgacagaa tctaatgttt tgatgactgt 3109261 gtcgtacttc agcttaattt ctgacataaa aaaagatcac caccatttta gtttactaat 3109321 tgtatttccg acttcttccg cgaactcttc tcccttttta agaagatctg ctgcaccatt 3109381 tgctatgaac aattccgatg catatttagc tttatcccat tcaagatcaa aaattttccc 3109441 gttaatcgaa gccatatact cgttatattt atcattcaca atcttagatg cttccgattt 3109501 cgcctcttct cttcccttgt cgaaatcatc ggcttttgtt cccgtccaat gcttgcccaa 3109561 ttccggtttc acaatttctt tgatttcagt gattgcctct tcttgcagtg tgtctatgtc 3109621 cttttttgct tttttcagct tttcgatctt gtcttccacg tctgaaattt ttccgttgag 3109681 cgaacttttg atatccgcta gcatactttc ataacccatc tgaatcacct cttaatactc 3109741 aaaaagtcgt atggaggggc tgatgaagat agacttttcc atactttatt tccatatatt 3109801 atattttaaa atagccagaa ggcggcttaa atagggtaaa tggcttaatt taggcatata 3109861 acgctcttga aatgtaggta tttgatcttg tttttgttcg ttatacagct aataaaagcg 3109921 ttttataaaa tgaaatcacc taatgtcata gttataaagg cacttgaaag aggcagatgt 3109981 tgttgatctg cctctttcgg cgctgagctt attgttcatg tttatgttct tcatctggtc 3110041 ggccatgtct gattttgtca tttggcttct attattcccc ccttctgacc ctttggatca 3110101 aaagcttgta ttagctgcag tcccagttgt acagaacgtt tgaaaagtct tttttcctta 3110161 gatcttcagg tgtgatgaaa aaattggcga tgccgacgtc tccccacatt gaatcgatat 3110221 catcgtctga atcaatttgt aacagcatga tggtgtgttc tttatatgcg tattcccggg 3110281 gatcatgctg ggtaaaagaa gcgtatccgc caattttatg gccaaatccg ttttcagcca 3110341 gttcattata aatgtcttct tcatcctcgc cgaactgacc aaagaactcc attgtttcca 3110401 tgcccgtata ctgctcaaat tgaaaatctg taggcagcac ccattccgaa gatttcacag 3110461 gctcgactgc cgcttctgat aaaatcggaa aatcacattc gcctgtgcca ataaatgaaa 3110521 aatcagaaac aagctcgtca tcgttttcta cgatattttc aaaatagatc actctgaaat 3110581 tcttttgttc acatcgatcg tcaaaattca atccatagac gtcatcatga acagaaatgt 3110641 agaactgcag gatacctgaa gaagggtagc cgtcaagctg gggaatgtgc gagaaattaa 3110701 tctgcgccag aagtttcatc ggctgtccat tttcgtcagt cggatatgtt tcatgcttgg 3110761 ggaaataggg atcaccggca attttgctgt catatcgtcc tgttttcccc tttctcacat 3110821 tcagtttcac gtattctttc gctgatttct ccagcaagtc gcggtacggt ctcatttttt 3110881 cgggcagatg attcatcaga ttctctcctt ttccggcatc tccaaggttt tattttctgg 3110941 ttttcttcta atgtttttca aacgaatgtt taaagaagcc ctacttctgc ataattttcc 3111001 aaacaatagt taaatagtag caaatgtatt cagcaccccg caatagatga aaaaaagact 3111061 ggtgcgcaac cagcctttct ttttcatcta ttgaattgca cctgacggaa caaccgcctt 3111121 ccgtccgaca gaataatact ccactcctgc agccaaagcc tcatccaatg tgtagcagtt 3111181 tctgccgtca aatatgagcg gcgtttccat caaatcctga taagccgcta acgggaattg 3111241 tttaatgtca gcccagtcgg ttaaaatcat gacggcgtca gaccctttga cagcttcctc 3111301 gatcgtctct ttatattcaa cagcttgcgg gagaacatgc tttgcatggc taactgcaat 3111361 gggatcgtag gctctgatac gggcgtcgag cgcagcgaga cggtctgcaa taacaattga 3111421 cggcgcttct ctcatatcgt cggtattcgg tttaaatgac aggcctaaaa gggcaatcgt 3111481 ttttcccgtc accccaccga gcctgttcag cgctttatca accagcatcg cctgctgatt 3111541 gttgttgact ttgataacgg atttcagcag ttcaaaatca tgctcgacat tgccggcaat 3111601 ttgcacgagg gcgtttgtgt cctttggaaa acaagagccg ccgtagccta tgcccgcttt 3111661 taaaaactgg ctcccgatcc gcttatcctg tcccatcccg tatgcgactg cttcaatatc 3111721 ggcgccgacc ttttcacata tattcgaaat ttcgtttata aaactgatct tagtggccag 3111781 aaaagcattt gaggcatatt tgatcatctc ggcgcttctg atatccgttt ggtaaatcgg 3111841 gatttgaaac ggacggaaga gctcctccag cgtatttgct gttttctcat cggccgtccc 3111901 gatcacgatc ctgtcaccat gaaaggtatc atagatcgcc gacccctcac gcaaaaattc 3111961 cggattggat gcgaccgaaa tactgacagg ctccgctaga tgttcagtaa tcagtccatt 3112021 aatcaaatcg tttgtcccaa cgggcactgt gcttttcgtt accacgactg tatctcgttt 3112081 gacatgcttt gcgatgcgtt tggccgcatc tgtaatttgc tccagattgg cgtgcccgtc 3112141 gcttttctgc ggtgtgccga ccgctataaa aatgatgtct gcctgtgcca agcctttctc 3112201 atagctcgtt tcaaagttca gccgtccatc agctgtattt tttctcatca gctcttcaag 3112261 acctggttca aatatggggg aaatgccctt tctcatttca tcaatcttgt gagcgtcaat 3112321 atcaatgcag gttacatgat gtccaatctc agaaagagaa acacctgtca caagaccgac 3112381 atagcctgtt ccgatgactg ttatattcat tgtttccctc caacagttaa attgctgctt 3112441 tgcagcttcc gtaatatcgt atgagaacat cctatcatga atgcgaatga tctcccgcat 3112501 agcctgtcgg gtacagcctg tacagatttc tgaaatgtga ttcaaccata caatacacta 3112561 ttatatcgct ctcaaaaaga aagtggtgaa atgagaatcg gctgttaaaa aaaaccaaac 3112621 aattttcttc ttttgaccgg ctgcggaggc tgtctgaaga tggtctgatt ccgcaggaga 3112681 agctctgcat tttccgtcag catataagga agttccgagc cgaattcttt ctctagaaca 3112741 taaagagcct cttgagtgtg aaaatttctc gttttcacat tatgggcatc tgaggctacg 3112801 aaatggatca aattggcttc aaccagccgg agagaaaatg ctttcagctg cttgccgaag 3112861 atccccgcaa gacttcctga agtaatctga gatgctgctc ctttttccac aagatgatac 3112921 agcaaggacg ggttttcgcg aatttccctg ttgcgttcag gatgggcgat aaccggaata 3112981 tatcctttca gctgcaaatc ataaaaaagc tgctccgcat atcggggaac gtgatcaaac 3113041 ggaaactcaa tcaagatgta ttttgtatca ttcagcgaaa gcagctgacg tttggcaagg 3113101 tcttgttcca cctcgccgta gattctgatt tcctgtcccg gaagcacatg taaaggaatg 3113161 tcttctttga ttaaacgttt gtttaactga tctgctgctt ctctgactgc ggctggctcg 3113221 tttttataca caccgttgtt atgatgaggt gtcgcaatga tcgtccggat tccctgacga 3113281 acagctgctc ttgccatttc tatgctgtcg gccgaatcac ctgccccgtc atccattgcg 3113341 ggaagaatgt gacagtgaat atcgatcatg tcctagcccc cttttttcgc aaaaataaat 3113401 aacgggcacg atgcacgtta tttatttttg catgaaattg tccttggttc cgtaatatcc 3113461 gtattcagag tgcttcgaaa gctttttgcc gttcataatc gccccaagga gcttgctttt 3113521 gcacgttgca agcgcctctt tcgcttttgc ggcttgttct ttttctgttt tcccgcttga 3113581 aataaccaga acagaaccgt ctgccacgtt gcctaaaatc tgtgcatctg ctacggcaag 3113641 aataggcggc gtatcaaaaa tgaccatatc atatgccgca cacgcttcgt atgcaagctc 3113701 cttcatccac ttcgaggaga gaagctcggc cgggtttggc gggatcgggc cgctcgtcag 3113761 cacgtcaaga tgtttttcat tcgatgcttg tacagcctgc tccatagagc ttttctttaa 3113821 taaaacagat gttaagccaa ccgtattttc aagaaaaaaa gccgtatgta ctgttggttt 3113881 tcgcaaatca gcatcaatca ggagcacttt ttttccctgt tgggcgaata cgacagccag 3113941 gttggcggcc gttgttgatt ttccttcccc cggacaagcc gatgtaatca tgactgattt 3114001 catttgccgg tccactgaag caaattctat attcgtgcga atcgtccgat attgttcaga 3114061 gttcaaggat ttcggctctg tcattgcaat gacatttctc tgcatccgcg agcctctgtt 3114121 ttttctaagc gccaaaatgt ccactccccg ttttttcaga ttggaaaccc tgtaaggtct 3114181 ttgctgtttt ctgctcattc gcaatggtgg aaactgtccc taaaacaggt atgtccagca 3114241 aggattcgag ctgctcttcc gatttgatcg tattatccaa atgctcaagc aggaaggcca 3114301 gtccgatgct tcccgccaat ccggccgcaa acgcgatggc aatgtttagt agcggctttg 3114361 gcgatacagg ggacgggtgt tctgaaacct cggcttttga cagaatgctg acattgtcaa 3114421 cattcataat ggatgtgatt ttgtcttgaa aaacagatgc tatagtattg gcaatatgag 3114481 ccgctgtttc cgcgttttca tccctgactg atatgttgac cacttgggag tcctgttcgc 3114541 tggatacggt aattttgtca ttcagttctt gggatgtcat cgacaggccc atttctttaa 3114601 tgacttcatc taagatggca gggctcttaa tgatgacatt gtacgtattg attaactgaa 3114661 gattggtttg gacatcgtta aattggactt cttttcgttc atttttcgat tggttgacca 3114721 gaatctgagt tgaattttca tagatgggtg taagtgcgaa gaaactaatg agtccgccgg 3114781 cagcagtggc agccgcggtt acaatcataa tcaaaagtat gcgttttgtt aacgttgata 3114841 atatctcttt taagcttgta gattctccca tgatacctcc aaatctctta taacatcctt 3114901 ttccatctac gattatacaa cgttgaaacc gcatttctcc agcttttcac gtgacataat 3114961 tcgacatttt tttacaatgc gttatgttag tactttttat gtaagcgcta tatttactgt 3115021 gttgacagtg ctgtctcatt ttctcttatt cgggcagtca cgttctctcg cataaaaaaa 3115081 tcccgctaaa ggcgtgcggg atttttatgt tgcatatcca tttttaatat gagaaatcaa 3115141 attttcaagc atttccttcg tcgtcatctc agatgactgc tcaccaattt catgtgcatg 3115201 catcaaaatt ttcagaaatt cttcttgatt caatttcttt tcactcatct tttttttcct 3115261 ttcagcttcc attaagttga aaacacgatt attatatgat gctggttatc aatttgcaat 3115321 ctctaataca tcattcgaca catcctattt tttatgtcct tttttaggaa aaacttttta 3115381 aggccgatgt gttgcgatat aatagagaaa ttggatcttt ttattacgtg actcggttag 3115441 gagcgataat catgcttcag aatatgattt ccaaagacga tgtgctggca tctgctgaac 3115501 agttaaaaga acttcttcct tacaatgagg aaaatgttca gctgatcaaa aaagccctta 3115561 ttttatatcg gcaggattca gtctatcgtt tacaagcagt gagtccgacg gaagttacgg 3115621 cttacgtgca ggatgttgtg cctgtgcggg tcacattgaa cttgtttgtc atagtcaaaa 3115681 gcggctgttc atgtccgtcc ggaagaatct gccgccatat gctggctgtg tttttatatg 3115741 tatatgcaat gttcgagcga gtgggtactt ttacagagta ttggctggag agggaaaagc 3115801 ttgaggaaag caaagagctc gtccgccgcc agtttcagga aaaggtgctg cctaatgaag 3115861 aatcactttc aagctggctt gctttttttg attcagagtt ttctctctgg caggcacgta 3115921 cgccagaagg cagccaaaac atgcagggcc tctattacgg ctacctgtcc gcattaaaaa 3115981 aacatgcgcc gaacaagccg gagctgaaaa gcctgtatca gattcattcc gcgattgcgg 3116041 tttggcttcg catgttcaca ttgattgaag cgggcaagct aaaccccgaa caagattttt 3116101 attccctcaa tccgtacgtt gaacagctga tggatacaat ctacagctct attgataaat 3116161 taaaaacgta cgcgctgtct tttgcgcttg atccgttttt ggataaaaca ccggatgtta 3116221 tccggcattt gctgttgaaa gaagaaattt tccaatatga acgcatccgc gtcttcggtg 3116281 aaatttggag tgcgctgctg tcgcggccaa aatgggtggc acgcgaacag gagatattga 3116341 aaaaagaagc aggacggcgt ttttctcccg aattgcaatt cgggcgcctg catttggaat 3116401 tcctgcaaaa aaatgatgac gttatttttg aggaagcgga tcaattcccg ccggaagcgc 3116461 tcccttatac attccaatgg ctgagtgaaa tgactgccaa gaaggactgg aaacggctta 3116521 aaacatggta ccagcaaatt gaaccaattg cgatgggtta tacgaagctg gataagccgt 3116581 ttaaagagat tcgcgatgtg atcggcgagc tgttccttct gttgaatgcc tatgtgcagc 3116641 aaaccaatga tcaagcgctg tttgagcgct ttgccgcggg ctgtctgccg tatacgttca 3116701 cagaatacag ccatcattta tatgaaaaaa aacgctatgc cgagtggatt gaaattcata 3116761 gccttgtcgg cttttccatc aatgaaatgg ataaaatgat gctcaaggaa attgcagcga 3116821 gcgaccctga ggcgcttata ccggcttacc atagagaagt ggcttttttc attgatcaga 3116881 agaaccgtag ctcgtacaag gaagccgccc ggtatttgaa aaaattgcgc accctgtaca 3116941 aaaaagcgaa aaagcagaag gtgtgggagc ggtatattca gctgctgagc tcgcattaca 3117001 agcgcctgcg tgcgcttcaa gaagaactgc agaaaggaaa gttgattgat ggcgagtctt 3117061 aaagaaattc tcatccacgt cgaacaaatg gaagatgggt catttacgct ctcagccttt 3117121 gatgagaatg agcagcctct tccctacagc catatgaaaa agcatttgtt ccaatggcat 3117181 gaatcctcat tttacggaac ctttctagag gatgtcagct tcatcgggac gactgctgtc 3117241 cttctatctc catggatgac tgtagagctt ctcggcaaaa actcgttcaa ctcattcagc 3117301 tccgtgcagc ttacagaaga aacggagccg ctgatcgagg cggcatcgac catctatgaa 3117361 tttatcgcgg acggcgattt tatgcctgac tatgacgcat ggacaaacgg tgtttttcgc 3117421 tggaaggacc gcgataatat actggaaggc tttactgcgg aatggttttc cgctgccgta 3117481 caggattaca tccagtacga cgatgacctg cgggagaaat gggaacatat caaggaaaaa 3117541 tcgcctgcgg ttacgacatt ccgtggccat tttcttgatg aagaggattt tctggaaggc 3117601 attggctgga ttgacgatca atctccattt actgtcggct tgcgcttaaa tgaaccggac 3117661 tttgacggag acgaatggaa gatcgagatg tttttacgcg ataaaaagag cggtgctgta 3117721 gaattctttg acggactgaa gagcctcaaa aaatcgtggc aggcgtacag cgataaaatc 3117781 gcgcgtgagc aggaccgctt tcacagaacg gttccgtggc tgtcgtttga ttccgggaca 3117841 acgctgatct cggaggaaga agcctggatc ttcctgtcag aagcaagtga gacgcttgtc 3117901 gatatggggg tagaaatcct cctgccgtcc tggtggcaga ttgtcagaga cagcaacatg 3117961 atgctgaaag caaaggtgtc ttcctccccg cgcggcgagt catttgtcgg catgaatgca 3118021 ctgcttgatt tcaactggcg gtttgcgaca aatggaattg aactgactga ggctgaattt 3118081 aatgagcttg tcgccagcaa caggcgcctt gttaatatcc gcgggcaatg ggttaaaatc 3118141 gatccgcagt ttatcaaaca gatgaaacgc ctgatggaaa aagcagaatc agagggactc 3118201 cacatgtctg atattctggc gcgggagcta atggatcagc aggatggcgg acttgaggat 3118261 tcggacctga ttgatacatc tgcttttgcc ggcattcagt ttgatctgtc taaacagctc 3118321 aggtcactga ttcgaaagct cactgccgcg gaaaacctgc cggagcacaa agtcagtcct 3118381 tctttcaaag gaacgctccg cccttatcag aaatacggca tgaactggct gctgtttctg 3118441 cgggaaagcg gttttggcgc ctgtctggct gacgatatgg ggcttgggaa aacgattcaa 3118501 atgatcgcct atttccttca cgtgaaggaa agcggccgac aaaaaacgcc tcatttgatt 3118561 attgcgccga catccgtact tggcaactgg cagcgggagc ttcaaacctt tgcccctgat 3118621 ctgtctgtcg cgctccatta tgggccgcgc cggccaaagg gtgatgattt cgccgcgcat 3118681 tatgaaaacg cagacgtggt gctcacttca tacggtctgt cacatgccga tactgaagag 3118741 ctttcttctg tgacatggaa cacgatctgc cttgatgaag cgcaaaatat taaaaacgcg 3118801 catacgaagc aatcacgcgc aatcaggaag ctgaaggggc ttcaccatat cgcgctgagc 3118861 ggcacgccga tggaaaaccg actgactgag ctgtggtcta tttttgactt catgaataaa 3118921 ggctacctcg gcagtttgac cggcttccat aaacgctatg tgctgccgat cgaaaaagac 3118981 cgggacgaaa agagaatcgg acagcttcag caattaatcc ggccattcct tctccgccgg 3119041 acgaaacggg atgaagaggt cgcgcttaat cttcctgaga agctggaaga aaaagaattt 3119101 atccctctgt cagccgagca ggcatccctt tatgagcagc tcgtcaaaga cacttttgac 3119161 catatgacat ccctgaccgg catgcagcga aaagcgctga tcctcagcat gcttggacgg 3119221 ctcaagcaaa tatgcgatca tcccgcgctt tatttaaagg aagagcaaac cgagctgctg 3119281 gccggcagat cagtcaagct cgaaaaattg ctggaactga tgacagcgat ccgcgcccaa 3119341 aacgaaagct gcctgatttt cacgcaatac attcagatgg ggaacatgat gaagcggctg 3119401 cttgaaaaaa cgttcgggga acctgtgcaa tttttaaatg ggagtctctc caagcaagag 3119461 cgggatacac tcgttgagaa atttcaaagg aaagaatatc cgacactgat tctttcactc 3119521 aaagctggag gcaccggact taatttgacc gccgccaatc acgtcatcca ttatgacaga 3119581 tggtggaacc cggcggttga aaatcaagcg actgaccgtg cataccgcat aggccaggag 3119641 cgctttgtcc acgttcataa aatgattacg acaggaacaa tcgaagaaaa aattgatgtc 3119701 atgcttgaat ccaagcaaac cctgaacgat caaattatcc aaagtgaaaa ctggattacc 3119761 gagctttcca cacaggagct cgaagaattg tttacattaa gcgctacagc gcaataatca 3119821 tgactaaaaa agctggctct aaaagagcca gcttttttcc gttcatagcc gtcacgccga 3119881 atttccaaaa aatccgttac gccggttatc aacagggtgc gcttttgtgg cagcacatat 3119941 acttacaaca aatgtttcat catatgtgcg acaccgtgtt cgtcattggt taaggtgaca 3120001 gcatcggcta tcgatttgat gtcttcccgg gcattgccca tcgctacacc ttttcccgca 3120061 gcctccagca tcgatttgtc atttaaactg tcacctacag cagcagtttc ctcgagcgga 3120121 atattcagct gttttgcaag cctcttcagc gcctgcccct tggaagcttt gcgggaagaa 3120181 agctcaaagt tgtgctcagc cgaactgaca agcgtcaaat cttcggcatg ctcatatctt 3120241 ttccagcctg cctcaagctt ttctttgaag aaagaaaagc cgagaatatt gtaaaaatcg 3120301 attggctcat cggcttcaaa cagctcttga aaggagttaa tgtaagcaaa gcccgattgg 3120361 ctgtattgca cctcggccgc ctgcttaagg acagaaagat ccgcttccgg atttgcgctt 3120421 ctgaatctgt cgagctcaac atcaagaagt tctctgccgt tttgcggcgt ataaatcgct 3120481 gaacctgtga atacctcata ataatagttt tccgactcaa gccatgagag aatgtcatac 3120541 gcccgtttct tatcaatcgt ttcgtgatga taaagcctgc cctcgggatc gtgaatgacg 3120601 gcgccgtttg cactgatgac ccatgttttg atccccagcg gttcaaagat tgacatgacg 3120661 tcaaaatgag cgcgcccagt tgacaccacc acttcaatgc cgtcccgctg cgcctgccgc 3120721 agtgcgtttt cattttccaa gcttacctga tgcttgctgt tgagtaaggt tccatctaag 3120781 tcaatcgcaa ttaatttcac gtttgtcagt cctttccttc atcctgctct gtcacgagaa 3120841 gctcaacgcc gtttcggtca agcaagtcac aaaatgcctg attcggcagc ctgtctgtaa 3120901 tcaagaggtc gatttcattc agctccgcat actgataaaa actggtgctg cccagcttag 3120961 aatggtctgc aagcgcaatt acctgctttg cctgctgtat cattttccgc ttcaccatgc 3121021 catcctcttc atgcgcaatt gtaatgccat gttcggaaat gccgaccaca ccaatcagcg 3121081 ctttatcaac atggtagctt gagagctttt caatcacaga ggacccgtac agaaagcggt 3121141 gctccttttc cagcttgcct cccagcagat aaatttcaat tccctcttta tcggacagca 3121201 catccgcaag attaatcgaa ttggtgatta cggtacaatc aaccgcattc aaatgctttg 3121261 cacatgcctg aacagttgta gaggcgtcta aaatcacccg gtctccatca tgaataagcg 3121321 atgctgcaag cctgccgatc ttattttttt cctcagacac tgttttcagg cggccggaat 3121381 agctttgaat tttctgatgc acagtcggta aaatggcgcc gcctcttgtg cggatgatgg 3121441 cattctgttc ctcaagtttc acaagatctc gtcgcgctgt atcccttgac acttgcagga 3121501 gcgtacagat ctgctccgtt gtaattcggt tatgctgttt taaaaaatcc aaaatcgcta 3121561 ctaatctttc ttcttggtac acgccctcat tccttttctc agcaatcatt tataagtaat 3121621 tataagtttt tatttgattt tattcaacat taataagtga ttttaagtaa aaatgcgtcg 3121681 agagaaccaa tttttcctaa gtaggcaaaa agaaagaacc agtctggtcg actggtcaat 3121741 tttgagggga tgatgcgaag atccggataa tagtgaatgg atagataacg ggaggagcag 3121801 gggtgtcaat cagcagcttt ttcccggggt ttagggtcca taaaacgaac agtgtcagcc 3121861 aacacttctg ttacatacac gttaacgcct tcctcgtttt catagcttct tgtctgaatc 3121921 cgtccgctta cgccgacgag agaacctttt tggcaataca acgccgtgtt ttcagctgtt 3121981 tttctccaaa gtgtgcaatt gacgtaatca gcttcgattt cacctgaagc attcttgaag 3122041 ctgcggttca ccgcgagcgt aacatgtgca actgccgcac cggcggaagt gtagcgaaga 3122101 tcaggatctt ttgtaagacg tccgacaagc atgacctgat tgaacatgcg attcctcctc 3122161 tccttgcggt tgtatgtatt gtaaatgatg caacaagaaa agaaaaacgc ttaaaaatgg 3122221 ctttcagcct ctgtttttat ctttcgtttt catttttcct tcagctaaaa acatcttttg 3122281 cttttttcct ttgaagaaat atgtactttt taaaaaacgg aaaaagattt gctttgtcag 3122341 ccagttttgc gtattcatgc gcacatagga agagccatcc cacgcaaacc actgaaagct 3122401 caattttttt tccggcattg acagcttgat tttatactgc tccatgccat cttgtgtttc 3122461 gtataaaaaa cttattcttc cttttttgtt cagatgaacc tcaaacactt ctttacggct 3122521 taacatatat gttacttcct tttgaatcaa atgactttca gaaggaacgc cgtcaatata 3122581 aatttctttt aaacgaaatt gattcatacc acatctctcc gtaatccata gtcagttaca 3122641 gtataatgaa aaaatagaaa ttattaaatg tttcgctcat acaaaattct ttagccccaa 3122701 cattgcagga ttttttcctc gaaaacgttt atgttataat ggaaggcaag aaaactttgg 3122761 aagtaatcgg ggtgagaaga aatgaaaacc tttaaactgg ttgacctgaa tgtggaacga 3122821 gtggacaagg aagaacaatc aattgaacag tttcccctta ttgacggact gattataaat 3122881 aaagaagacg gtgaaaatca ctggctgatt gaggcgcttg tacagaaaga acatctgtct 3122941 ttttttgaac agcttcaaaa cagccaatct gaagccaaag tatttgtaac gatcacgaaa 3123001 aaaagcaatc gccccgccca gctgacagca gcagtgaaaa atatcgtcaa gctggaagaa 3123061 agcattcagg ttttactcta cggacaaatg gtcacaagaa aacagcaggg cactgaaacc 3123121 attctcgagt cccttgtaaa agagggctat acaggaacaa aactcattga ggcatttaag 3123181 caaaaattat aaatatgagg gggcatgttc cccaaaacag actcagaacc gaagagcatc 3123241 acaatagaca tttagaatag atatgttctg catgaaaaaa gctgccgttt tgaacggcag 3123301 cttttctctt cgtgctttca ctcttgcata tttaatttgt atggccaaaa gaatcaacca 3123361 attccccttt cacaacgagg cgcccttcgg ttttgaccgc cttgtcacat gtgattaacg 3123421 taatctcctt tttgtttgtc tcctcaacta catctgcatc catttccgat atgatgtctt 3123481 tcgatgttac agaatagata taatcctttt taaaatccgt gatgacaatt tgggcacctg 3123541 tttttatgtt ttccagaggt ccgaacagaa gattcttttg cttcaaatga tggcccgcca 3123601 acggataatt tccctcaccc attttttgat cccggcgcat tgttgccgcc cctatcaaaa 3123661 gattttcatt ggttgtgcct tttacgatcg gaagctccag atcgacactt ttaattgtta 3123721 tccgccgcct tgattgtgaa gtaaaaataa gtatatttca cgtgctttcg acgttctcca 3123781 cttgactgga atgctttaat ggcgatcccg gcatctgtag cttcaggctt tccttcagag 3123841 gaatcagaaa tctcaaactc tattttctca gtgttcagca cataaccggc tggcgctttc 3123901 gtttcaacaa aagcgtattg tcccggtgca aggcctgaag ctgtgacttg atgatgccgg 3123961 atatgactgg tttcgaagtc tgtatgaaaa ttcgcgaacg attcagcatg gttgatcttc 3124021 cggttctgat cattacagct gccattatcg gccatgacaa atacaaggct tttcatgccg 3124081 gagcgaatga cattttgcaa aaaccctatc attactctga atttatggcg cgtattcaaa 3124141 acctgataat gatgaaacat acagcaaatc aagccacaag aatggaaatg gcgtttctcc 3124201 agtcgcaaat caagcctcat tttctttata atgtattaaa cacgattatt tctctcactc 3124261 atttggatat tgaaaaggcc cgggaggtaa cagaggaatt taccaactat ttaagaatga 3124321 gttttgactt tcaaaataca tcagccatca gttccttcag acatgagctt tcgattatca 3124381 attcctatct ttctatagaa aagacgcgat tcagtaatcg gcttgaggtt cttttcgata 3124441 tagatgaaga cattgacttt atccttccgc ctttaatgat tcagcccttg gtggaaaatg 3124501 ccgttcttca cggtgtcagc aagaaaagag gcggaggatg gatcaaactg acagctaaaa 3124561 aacaaagcaa aaatgagtat cacatcaaag tagaggataa cggtcccggg ataactccgg 3124621 aaaaacaaat agatctctta tcaacggatt ttgatcgcag cgtcggattg aaaaatatca 3124681 atcagcggct gaaacatttt tgcggaagcg agttgatgat cagcagcact ccggatgcag 3124741 gcacctctgt ctcaatgctc attcatctcg ctgaaacaac aggaagccct aaagaactga 3124801 aggacacaga acgaacctaa acgaaaattg agataaaaaa agacgccgtt tctaacggca 3124861 tcttttttat tccggcgact ttgcttgctg cttcagcagg tctctgattt ctttcagcag 3124921 ctcctcctgc gcatccaccg cttcctccgc agcctcttct tctgcttctt ttttgcgcct 3124981 taacccattc aaagtccgaa tgacgataaa aatggagaac gatataatta agaagttcac 3125041 aatcgtctgt ataaagctgc catatttcac tacagcatcg ccaaacgtaa acgacaggcc 3125101 tgaaaagtca agccctccca gcagcaaacc gaccaaaggc ataatgatat catttactag 3125161 agatgtgacg atctttccga aagcgccgcc tatcacaaca ccaatcgcaa ggtctacgat 3125221 attcccccgc atggcaaagg ctttaaattc attccacata caatcacctg cttttctata 3125281 tttgtaaaga aaaaaagaca aatgtgccgc tggccatctg ccttttttca attattctcc 3125341 gagggcaaaa gtcagttcta cttcgcaaac gacttcgcca tcaactgtgg caacgccttt 3125401 tccgcgcccg attgtgccgc gggcacgaat gatttcaacc tcaaggtgaa gctggtcacc 3125461 aggcttgact tgttttttaa agcggcagtt atcaatgcct gcaaaaaaag ccagtctgcc 3125521 gcggttttct tctttaatca acatcgcaac agctccgact tgagcgagtg cttctacgat 3125581 taatacgccg ggcataaccg ggtactgagg aaaatgtccg ttaaagaact cttcattagc 3125641 ggttacattt ttatagcctt ttgcccgttt gccctcttca acttccgtaa tccgatccac 3125701 aagcaaaaac ggataacggt gaggaataat ttctttaatt tgctgagtat caagcattgt 3125761 cttgacatct ccttcatctg cattagtatg tatagcaatc atcaaagatc caatctgtac 3125821 atttgaaaag tatattatga attaatctct ttttcaaccg cgctaaaatg taaccaactg 3125881 tcaatgagag ccgtcaaaag ttatgatatg ataattatag attttaccaa tagcaaagag 3125941 gtaggaaaat gatttcgaag tttattgaaa aaagaatgct aaacatgtta gacgagtggt 3126001 attccgcaat gagcaaacgc aaaatgaatc acgtttgcac actgaaagag aaaattgatc 3126061 agcaccttcc aaagatcaaa aagaacacaa aactttggat gcgttatcaa ttgtttcagg 3126121 cccgccatca gctgcttttt gaaaaccaga acggactcga ttcattgttc gatggcctat 3126181 atggcctgga agacaaaatg gatgatgaat tgaaatatta tctgtatttt ttctctgggt 3126241 tatatgagat ggtaaaaaca gctccgaaac atgcagtaca tcattttaaa aaagctgaac 3126301 agtacctggc cgccattcac aatacgtttg aagccgctga tttatattat caaaccgccg 3126361 gcgcctatta cttgatgaaa tcaccgccgc tttccgtcca atacgtcaaa aaagcattac 3126421 acatctattt gcaccaattc ggctatatca aaaaggtaat cacctgtaaa cttttgctcg 3126481 ccgtgaatta tattgatcaa gaacgctatg aaaaagctga acagcttttc aaagaaatca 3126541 ttaagaaaac ccagcaacta catgacgaaa acctgctatg ccacgcttat tataaccttg 3126601 gctttttaaa agcgaccgag aaaaaagacc aggaagcgct tctttacttt agaaaagtat 3126661 taaagaatca agaatttgaa atgaattcac cagtctcata tcttcattgt gtgtacgagt 3126721 ctgtcagagc gctttttaaa acagggaaca tcacagaagc taaagccgtc cttcaaaaag 3126781 gaaaagaatt atctgaaaag gtagacattc aaaccattta tttaaaatta aaaacgcttg 3126841 aagccctcta cacatcagcc gaagaccctt atgagcagct gctcgaatat gtgcttgaat 3126901 tagaaaaaat cgaggcgtgg gtggatttag aagtgctgtt agaagatatt acggaatact 3126961 acaaaaaaaa ggacgatttc gaaaaagccg ctttttttat catgcgcggc tgattgaaaa 3127021 acgcccattt tcttattatc tgactgaatt gattaaaccg agcatttgat ctcccattgt 3127081 gatcgttctg ctgttcagct gatatgaacg ctgggacgtg atcaaatctg tcatttgttc 3127141 tgaaatatcg acattggaca tctcaagtga gccctgctgc atgccgatgt tttgtctatt 3127201 agcgccgttc agctcttcaa aagctgccgc attatcaata gagaaaaggt tattcccttc 3127261 ggatttcagc tcttgagggt tattcacttg gacaacgcca agattaaacc gctgaaccgc 3127321 gtttccgtca gatgcggtta aggtgccgtt cttattaatg gtgatattct tcattgagct 3127381 gtcgatgttc actgtattgc cgttctcatc aagtacggga tacccatttc cagtgacgag 3127441 ctgcagctgg ttggcattcg cagcggacgg cgttacatac agcgccccgt ccctcgtata 3127501 ctggcggttt ccatttacat ttacctgaag atactggtat ggagacgtaa atgcgatatc 3127561 cagatcgcga tcggtcttct gaatgcttcc ttgatcagag actaggcgtg aactcatcat 3127621 cgctccgacg ccaaggcgca agccgggcgg cgtttttcgg gcttttgcca cttcctcgtt 3127681 tttttcatca acctgatcga attgctgtct gacaagctca gaaaaattcg tatcttttgc 3127741 cttatagccg gttgtgttgc tgtttgaaag gttgctgctg attgtgtcaa tctgctgctg 3127801 cagctggttt aaggttgttg atgccgttag cattgacctg agcatagttg atgtcccccg 3127861 tttttttctt ccgttttctt aaatttttcc aatttcattt gctgctttat ccatactttt 3127921 atcgtaagcc tgaataacct tctgattcgc ctcaaacgat ctgtacgctt cagtcatttc 3127981 tgtataggcg cttgtcacat ccacgtttga aagctctgag acgccttgtt ttaatgaata 3128041 ggctacctga ttatttccgg ctgcgcttgg cagatcatta ccgtccgccg tgctgtacaa 3128101 atcatttccg tcccgtttga gattgcggac atcttccgcc attctgacat caatctggcc 3128161 ggctgtgcgt ccgttcgttg tcacagtacc gttttcagac acagtgaaat tctcattatc 3128221 aacagtgatt ggctggcgat ccgtcgataa aatagggcgt ccgttgatcg tcagctgatt 3128281 gttctcattt agtgaaaatg tgctgctttt tgaataacgg attccatccg ctgtttgaac 3128341 cggataaaaa agagcagctt tttcattggt ttccgcactc atcggaactt gattttcgat 3128401 caatgcaatg tctgtaggct ggtctgtgga cttcaggctt ccctgtgtaa agagaggctt 3128461 gagctcctgc atatatactc cggtattcac ggaaccgatt tccgtccttg atgtcccggc 3128521 cggagatttt gattctattc tgctgagcag catctcaggg aacgcgcgca tagagccttg 3128581 atcagcttta tatcctgatg tatttgcgtt agcaatatta tttgaaagca tttccgttct 3128641 tcgctgctgg gcaatcattg cggatgttgc tgtatataat ccttttaaca aatttcccac 3128701 ctctaaaaat ggcatttttt ccagttgtca tataggaacg ttcgttctat aataaaaact 3128761 cagtatttta tcctattatc gtcatttaac atcttttcgt gaaggctttt tcataaaaaa 3128821 acctcattct ttttcagaat gaggtttgtg aaatcagctt agtttgcgtt taggaagctt 3128881 gtccatatta tcaagcatga cacctgtgcc gatggctacg caatccatag gattttcagc 3128941 aacgaggacc ggtaccttca gctcttcagc aagcagctgg tcaaggccgt ttaagagcgc 3129001 gcctccgccg gtaataataa cgccgcggtc aataatatca gcagaaagtt caggcggtgt 3129061 tctttcgagc acttgttttg cagcctgaac aataacagcg acagattcac gaagggcttc 3129121 ttcaacttct ttactgttta ctgtaattgt tcttggaaga ccggaaacca tgtcccgtcc 3129181 gcgaatggaa atttcctcgt gacgtgcgtc tgggaaaaca gttgcgactt taatcttaat 3129241 atcctccgca gtacgttcgc cgatcagcag cttgtactcg cgtttgatat aatttaagat 3129301 ttccatgtca aacttgtccc cagccatttt aatagaagag gaggtgacaa tatcgcccat 3129361 tgaaataacc gcgatatccg tcgtcccgcc tccgatgtct acaaccatgt taccgcttgg 3129421 ctggaatatt tccatacccg cgccgatagc ggcaacttta ggttcttctt caaggtacac 3129481 atgtttcccg ccgctttttt ctgcagcttc tttaattgct ttttgctcaa cggatgtaat 3129541 attcgtcggg cagcaaatga gcatgcgcgg ctttgagaac aggcctttta cattcagctt 3129601 gttaataaaa tgtttcagca ttgcttctgt tacttcaaag tcagcaataa ctccgtcttt 3129661 cagcgggcga atcgcaacaa tattcccagg tgtacgtcca accattcgtc ttgcctcttc 3129721 gccaaccgcc agcactttgc cgctgttttt atcaagtgca acaacggaag gttcattcag 3129781 aacaattcct ttacctttaa catggatcag tacatttgca gtaccgaggt caataccaat 3129841 atcccttgca aacatctatt tatatcctcc ttgaaaatct gtttcacagt aaatatccac 3129901 attgtgccct aattatatat attatcataa aatatagaaa aaaagttgga agcacaataa 3129961 gttctttaca aatttttgcg gatgttttat gaacgatttc aagaaggcaa tgccaggtga 3130021 ttacgattgc tgaacaggct ctccttcgag aatttcatct tttttatatt tgagctttgt 3130081 cgcttctcct cctcttaaat gcctgatgga tttatgataa tcgagtattt ctttcacttc 3130141 gtttgccaag tcggggttaa tttcaggcag acgctctgtt aaatccttgt gtactgtact 3130201 tttggaaaca ccaaattcct tcgcaatgac acgaacggtt ttctttgtct ccacgatgta 3130261 cttccctatc ttgattgttc gctctttgat gtaatcgtgc acaccactcg acctccctaa 3130321 aatggatgtg agaagtgtga aatgagatcc gtattctgta aagagtcgtt cattatgccg 3130381 cttcttcgtt gtatggtttt aaaagtaagt ttgtgaaata tgcccacgat ccctcacctc 3130441 aaacactctc tttgttaggt ttgtaacagt gtattagcat tcttttggga atatgctaaa 3130501 aactcaataa ggacaagggg tgaaacgaac tttttcagat tcagcaaact atttcgcgtc 3130561 actaaatttt catctttaca actattgatc gctcctgtaa aatgaaataa gcaattagtt 3130621 acttaggtaa gttttttaga aggagaccga catgtcctac gtcaacagac acctcattca 3130681 tcaaatcaac caaagcgccc gcctgattgc caagaaagcc aatgaacagc tagagccatt 3130741 cggcctttat tcatctcaat ggtcagtttt atattgtttg cgtacgatcg gaccaatgac 3130801 tcaaaaagag atttggtcct atttaaatgt ggaagcgccg actgtgactc ggacgatcaa 3130861 acgcctggag gagaacggct gggttcagag acggcaaggt gaagacaaac gggaaaaact 3130921 tgttgtcctc acaaaagaag ccgagaaaaa atacgaagaa atcaatgtga aaatgttgaa 3130981 attcgaggaa gagctgcttg cagatttccg ggatgaagat aaagaagctt tttctcattt 3131041 attccgcatg tttttacaac aatgaaaata aggaagtgac atacatttga aaaaagcgga 3131101 tgcgatatgg accaaggatt ttattatggt cctgcttgtc aatttatttg tgtttgtgtt 3131161 cttttataca tttttaactg tattgccgat ctatacactg caagagcttg gcggcacaga 3131221 atcacaaggc gggcttttaa tcagcctgtt ccttctgtct gcgatcatta cacggccttt 3131281 ctccggagcc atcgttgagc gtttcgggaa gaaaagaatg gcgattgtat caatggcgct 3131341 cttcgcccta tcatcttttc tgtatatgcc gattcataac ttttccctgc tgctcggatt 3131401 gcggttcttc caagggattt ggttcagcat tttaacgact gttacaggtg caattgccgc 3131461 tgatattatt ccagccaaac ggcgcggtga agggcttgga tactttgcca tgtctatgaa 3131521 cctcgctatg gcgatcgggc ctttccttgg cctgaatttg atgagagtgg taagctttcc 3131581 tgtattcttt acagcctttg cgctgtttat ggttgcgggc ttacttgttt cgttcttgat 3131641 aaaagtgccg caaagtaagg acagcggcac gactgtattc cgttttgcgt tctcggatat 3131701 gtttgaaaag ggcgcactca aaattgcgac ggtcggtttg tttatttctt tctgttattc 3131761 aacagtcaca tcatatctgt ctgtattcgc caaatcagtt gacctttcgg atatcagcgg 3131821 atatttcttt gtttgttttg cggtgacaat gatgattgca cgcccgttca cagggaaatt 3131881 gttcgacaaa gtcggaccgg gcattgtcat ttatccatca atcctgattt tctctgtcgg 3131941 actctgcatg ctgtccttca cacatagcgg cttaatgctt ctgctttcag gggcggttat 3132001 cggtcttggc tacggatcaa tcgttccttg catgcaaaca ttggcgattc agaaatctcc 3132061 ggctcaccgc tccggttttg cgacggcaac gttctttacc ttctttgaca gcggaattgc 3132121 tgtaggatcg tatgtattcg gattgtttgt agcatctgcc ggcttctctg ccatttattt 3132181 aacagcgggg ctgttcgttt taattgctct gcttctctac acgtggagcc agaaaaaacc 3132241 tgcagaggct gaaggaaaag tgtctattgc agaataactt gtcagactgc cgggaaatcc 3132301 cggcagtctt ttttccatta aaacacggcg ccctctcggt tgaacgagag aacgccgctt 3132361 atagcaatta ttcaatgaca ggccgcgcag gtgaatcagg atctaacgaa aaatcatagg 3132421 acgcttcatc acgaaacatc ggatcggcat atatggattg ttgatcgttt tttgttgctt 3132481 ttcgatacga agaaaatgaa tcatattctt tctttttcca catccatatg ccgtcttgat 3132541 ccgcttcctt gtggtacacg ttatgattga ccgtattacc ttcgttttct gtaaagtcgt 3132601 ttccgataaa taatctggaa tcaccggccg tcaatatatt cttttcaatt gtgttgtttt 3132661 tcgtatcgta ctgcagcagc agctgtccgc cgtacagtcc ctttgtgtca ttccggtaca 3132721 taatattgcg ggcaatcaga gaattgctgg tgccgccccg ctttttgtca tatcctccga 3132781 ttgaaatacc ggtgtacgca ttgttgtaca ctttgttgtc tgtgatctga atggcatttg 3132841 catactttcc tttgtgttca gacgttgctt caatcccaat atcgttatcg taaactgtgt 3132901 tgttcttaat ttcgatatcg tgtcctccat cgacataaat cccgcccgct gagtattcat 3132961 ctccataagc aggattgccg taagtcgagt tttgataaac tgtattgttt tctacgactc 3133021 cgtttcgcac gtaatcgttt ttatccgcgg ttccctcata accaattaga tcaatcccga 3133081 tgttattatt gttgcggacc acattgcctg caactgtgaa gccgtcgata ttaccgttca 3133141 gcacaactgc ttcactcgct ccaagcgtca gtttctcaac tgtattgtcc tcgattcgga 3133201 tgtctttcat gctgccagtc ccataaactg cgattccgtg agcatttcct tcatccgctg 3133261 ttgtcttaat cccccggatg tgattatcct taatggcgat atgactgctg gaccctgata 3133321 cataaatccc tatagcagtt gcttcctcag atgaaacaga aagatcttga attgttaaac 3133381 cgctgatggc aatgtcatgt ttatcgtgaa tacgaataag cggtgtttca tattcagcgt 3133441 tcgcaacgga ttcaccgcta atcacgacgt tttcattttc atagtttcgg aatgtgatag 3133501 gctttccgtc cgtaccgctg tgctttacat caagggtctc atgatacgtg ccctcccgaa 3133561 tcatgacagt tgtgccggca gcagccttct cagatgcgtg tgccaatgta cgaaacggct 3133621 tttcttttgt tccttcattt tgatcactgc catttggcga aacatacaga taatccccag 3133681 atccttcctc attcgctttt gtcttatcat aaacgaaagc gaggatgaca gacgttaaaa 3133741 cacccgccaa aagaataaaa taccattttc tcattttcga ttcccatttc gttttagaat 3133801 agatttctaa aaccattata aatgttctat ttatggaaaa ccatttcaaa aatatgaaaa 3133861 tataccgtct aaatagatct tattcagcct ggcggacctg cgcatgttca actgtttcaa 3133921 ttgccaatga tgcaggcggg tgaacacgca tcagaacaat gtagaaaaga aaggaaatca 3133981 gcacacctac aaaccaagaa atatcgtata agctcttcaa tacaggaaca tacatgccaa 3134041 tcagcgaaat cagcgctcct aacattgtgg ctgcaaacgc acggtaattg tagcccttcc 3134101 aatacacata ccgtcctgtt tcggaataca ggtcatctac cgagagctca cgtttgcgaa 3134161 tgataaaata gtcggccatc atcacgcctg ccaccggtcc aagcatgccg cctattaagc 3134221 caagaaacgc atacacgctt gtcgcgctct ccatcagctt ccacggaacc gtaaataaag 3134281 cgagcaacgc tgtgataaag ctgccacgtt tgaaattgat atatttcggc agggcattcg 3134341 ctatatcata agcgggtgat acgatattcg ccgcgacatt tacagagatc gtggcgatgc 3134401 agagtgtgat cacggacaag acgatgacat aagggttatc aaaccgcgcc aaaatatcga 3134461 caacatccca aatcggctct ccgaacgcga cctgcgagcc ggaggtcacc gtaatacttg 3134521 cgaatgcgaa cagcgcaaac gttcccggca aaccgtaaaa ttgtcctttg atttgctctt 3134581 tttgtgtttc agcaaaccgt gtaaaatcag gtatatttaa gatcaatgtc gcccagatgc 3134641 cgatgatgcc agtaactccg gcagcaaacg gccagaatgt ttctgaaaac gtatgaaact 3134701 ttcctggttg agagtatatc gggcccaatc ctccagcaat atcaacggcc caccatacca 3134761 tgccgccaaa taccagatac actaaaggcc ctgcccacac ctcaaaacgt ttaatcgact 3134821 ccatgccgtg atgcaatacg agtaaatgaa tggcccaaaa gaatacaaag gaaagcaaac 3134881 cggacaagtg aatgccgaga atgttccact cgccgccaat ttctccccaa cctggccaca 3134941 tattcaaaag caaaatgttc agtgccgtgc tacccgcaaa ggtctggatg ccaagccaca 3135001 tgatagctgt aaacgccctt agaagcgcgg ggatattcgc gccgtatatc ccgtaagaag 3135061 cccgaatgat cactggaaac ggcagcccgt attttgtccc cgcatggccg tttaaggcaa 3135121 gagcgccaaa taggataagt gatgccgtaa taatgatcgc cagcacctgc caaggcgaaa 3135181 ggccgatcgc aattaatcct cccacggtcg cgtaggtcgg tatgttatgt atacatccca 3135241 tccaaatgga ggcaaagttc attgctttcc acgtccgttt ttcctgtccc aaaggcacca 3135301 gatcttcatt gctcagcctg ttggattgct gctgactctc ttttaatttc atagccggct 3135361 cccctttcca tattgtctat atgtcgtcac acgttatgtt ttttgacatt agatgtcact 3135421 taatataact gaagagtcag acaataacac tggctatgat atacaatttt cccgtttgta 3135481 tttgaacagc ttaaacaaga aaaagagaca gacctcagag cccgtctctt tcttaagatg 3135541 cagttttcat taatgcagca aatctcacag ccattaacag gcttgctccg cccgctataa 3135601 tcataatgat tcccatcata tcaaaatggg ctgccgtgat ttctttacca aaaagaatgc 3135661 caaggatcac cgaagacaaa atcgatccta ggtaacggca ggtttgaaac aggcctgaag 3135721 tcgttcctac catgttggaa ggactcgttt ccagcatcgc tgcctgaagc gcgacattgc 3135781 ccagtccgta gcctataccc aagagcgaca gaatgaggcc tttaccgatg gtctggacat 3135841 tgataaaaaa gatggttaag agcacggctc cagccgtcat caaaagcgct cccgcaaaga 3135901 tcggcttgac gacaccagat cggtcgatcc atttgccggt tagaggtgac acaacgatgc 3135961 tcattccaga cataaacagc ataaacaggc cgctcgtttg aacagaaaga tgcatttcat 3136021 cctgaaagta acttggcaaa ccaaaaaata aacaatagaa gaaaacattc aataaaataa 3136081 actgaacata cacggctgac aggtttcgct gtgttttaaa cagacggaca tcaataaacg 3136141 gcttatccgt tttcagctcg cgccagacaa acgcacagag cagaagcaag ccaagcacac 3136201 cttcaaccgc atgcggcgac gtgctgaacg acagcaaaaa ggatagaagg aaaatgattc 3136261 ccccggcaaa taaaacaatt ccaagaatat cgagctgccg aataatggtt ttgattcctg 3136321 cccctttttt ctgatctttc gggaacatat acaggcccaa taagaagctg aggataataa 3136381 acggcaaatt aacgataaag atcgccggcc agcctcccca tacaatcaaa aacccgccgg 3136441 ctgtcggccc cagcgccgtc atggcggacg caaaaataga gagtacagcc aaggctgaag 3136501 cttggcgctc atgaatatga ttccgaatca agccgacacc tgacggataa atcgcactgc 3136561 tccccaccga ttgaaacagc cgcatgacca ataatgtcat aaacgtcggc gcaaacggcg 3136621 ccccgatggc agaaaccgca acaagaataa gcccgaataa aaacaagcgt ttccgcccaa 3136681 tcaaatcacc gagctttccc gttacgggct gcgctacggc actcgccaag taaaacgagg 3136741 aaatcagcca ggaaaccgtt gtaaacgaga ggtgaaactc atgctggatg ctatggagcg 3136801 caagagagat catagacgag ttcagcggat tcagcattgt tcccgaagcc acagctgtta 3136861 aaaaaacagc tcggcttttt ttcgataaca tcatttcact tgttccagaa actcttccgt 3136921 tgtccgcgat ttaccgattc tcgggaaaat aaagcgcagt gtggcttcat gctcttcatc 3136981 gctaaatgtg gacatggcat ctgtaataaa aatctgctga tagccaagct gaaatgcctc 3137041 ccgtgctgtg ctttccaccc cgatattcgt tgcgatgccg cacaatacaa tcgtatcaat 3137101 gccgcgacgt ctcagctgca agtctaaatc tgtgccaaaa aaagcacccc attgccgttt 3137161 tgtcacagta taatcgccat cctgcacacc gatttccgga acaaattcgg cccagtccgc 3137221 cggcatttcc cctgaacctc cctgcgcagg ctcatccgtt tgcggcttca gggcgtccgc 3137281 tccatcatga aaggctacat ttacaaagct gatgaacccg ttatgtttcc gaaattcatc 3137341 tacgagcttt ttcgcgttcg ggacaacctg gccgctttga tcaatcggca caattccctt 3137401 ttgtaaatca atgataacca atgctgtttt ttgaaaatca atgttgagtg tattcatcat 3137461 acgtctcctc ctgatactgt tagtgtttct cacattgcat attttactct tcacactgcc 3137521 taagttcttt tatgatgctt gtgaaattct cagaaggagc gttttctcat gatttttctt 3137581 ttatgtagta gtaacaggtt gtgcatacga acaaaccggc aagcactgta atcataaagg 3137641 gcgtcatcgc ttcatcacct gcctgctgtc tatcggttcc tgcctgaaaa tgcccatgaa 3137701 tttgcggcgg tccatccaaa gcaggataag acacataacc attaatatcg tgctaagatc 3137761 ctgcacgcca atatcaaaac aatagttaat caagacgatg ttcacaataa tgggcataaa 3137821 aataaccgcc cctaatgcag ccgttcgcgg aatcagtaat aaaacagctg ccaggatttc 3137881 accaaaacct ataaacagtt catagacatg agaataaccg aaaaatgtcc acgcgatcgt 3137941 aaaccccttc ccggcagccg cctcgatttc aggcgtcacc tcgccaaact ggccaattac 3138001 cactttcgcc agaccgtaca cgaaaaaatt aaaggctaaa aacaatcgga acgtcgcggg 3138061 aatcgacttg cgtaccgctt tcctcagcct gccgccttta ttcatcatac atccccctca 3138121 gtgtattatt tgatgtagta cacttaatac agtatagagt attctaatta atgtcaattc 3138181 ccttttcagc tcatatgaat agtttctttt atagatacaa agtcttatat cgcaaaaaat 3138241 gccattctcc ttcctttcca tccctcgata acatttctca aaaaccatgt caggaaatct 3138301 tacatgaaaa tgttttatca ttcttttttc tctataatga agaaatataa taattgcttt 3138361 ttattctgaa agatacggag gaatgagaca tgcaaatggg cgatacagtt tttatgttct 3138421 tttgcgcttt actcgtgtgg ctgatgaccc cgggattagc gttattttat ggaggaatgg 3138481 taaagagcaa aaatgtgctg agcactgcca tgcacagttt ctcttccatt gccatcgttt 3138541 ccatcgtttg ggtgctgttc ggatatacac ttgccttcgc accaggcaat tcaatcatcg 3138601 gcgggctgga gtgggcaggc ctcaaagggg tcggatttga tccgggagat tacagcgata 3138661 ccatccccca ctcgttattt atgatgttcc aaatgacgtt cgccgttctg actacagcga 3138721 ttatttccgg ggctttcgca gagcggatgc gattcggcgc ttttctttta ttctcggttt 3138781 tatgggcctc tttggtttac acacccgtag cgcactgggt atggggcggc ggctggatcg 3138841 gccagcttgg agcgctcgat ttcgctggcg gcaatgttgt tcatatttcc tccggggtgg 3138901 caggacttgt tcttgccatt gtgctcggca aacggaaaga cggtacagcg tcttctccgc 3138961 ataacctcat ttacaccttc ttaggaggag ctttgatttg gttcggctgg ttcggcttta 3139021 acgtcggcag cgcattgacc ttagatggtg tggccatgta cgcgttcatc aacacaaaca 3139081 ccgcggctgc agccgggatc gccggctgga tcttagtaga atggatcatt aacaaaaaac 3139141 cgacaatgct cggagcggta tctggggcaa tcgccgggct tgtcgccatt acgccggctg 3139201 ccggatttgt cacaccgttc gcttccatta ttatcggcat catcggcgga gctgtttgtt 3139261 tctggggagt attctcgctt aaaaagaaat tcggatacga cgacgcgctt gacgcctttg 3139321 gcctgcacgg gatcggcggc acatggggcg gaatcgcaac aggattattc gcaacaacct 3139381 ctgttaactc agcgggcgca gatgggttat tttacggtga tgcaagctta atctggaaac 3139441 aaatcgtcgc catcgccgcc acttatgttt ttgtatttat tgtcactttc gttattatta 3139501 aaattgtaag cctcttcctt ccccttcgcg caactgaaga agaagagtca cttgggcttg 3139561 acttaacgat gcacggggaa aaagcatatc aagattctat gtgaggagtg acgctatgag 3139621 cggtcaaatg ttcaaggtag aaattgtaac gcgtccggca aattttgaaa agctgaagca 3139681 ggaactcgga aaaatcggag tgacctctct gactttctcc aatgtacacg gctgcggcct 3139741 tcaaaaagca catacggagc tctatcgagg ggtaaaaata gaaagcaatg tatacgagcg 3139801 tttaaaaata gaaattgtgg tcagcaaggt tcctgttgat caagtgacag agaccgctaa 3139861 aagggtgctg aaaacgggat caccaggtga cggtaaaata tttgtctatg aaatcagcaa 3139921 tacgatcaac atccgcacag gcgaagaagg acctgaagca ctttaatatc ggtacgagat 3139981 tcggacactc cggatctctt tttttgtgca cagaatcccc ccagaaaccg cgattcctct 3140041 tcgaattctc ttcaagcgcc gttatttcag acaatctcta tttttatttg aaacttttca 3140101 tgagtaagat tagtctacta aatataaaaa tgtaaaaggt gattatttga actacgaaat 3140161 ttttaaagca atccatggac tatctcatca caattcagtt ctcgattcca ttatggtctt 3140221 catcacggaa tatgccattg tcgcctatgc ccttatccta ttggcaatct ggctgtttgg 3140281 gaacacacaa agcagaaaac atgtgctata cgcaggcatc acaggaattg caggccttgt 3140341 gatcaactat ttgattacgc ttgtttattt cgaaccgcgc ccgttcgttg cgcatacagt 3140401 gcatacactg attccgcatg ctgcggatgc ttcatttcca agtgaccata cgacaggtgc 3140461 attagcgatt tctattgcga tgcttttcag aaaccgcaaa atcggctggc cgcttgtcat 3140521 ttttgggctt ttgacaggct tttcgagaat ttgggtggga catcactatc cggtagatgt 3140581 attgggcagc ctcgttgtcg ccatcattat cgggttcctt ttctttagat tttcagatct 3140641 gcttcgcccg ttcgtcgatt tggtcgtgag gatctacgaa gccattatca ataaactgac 3140701 gaaaaaacca accgatcaaa atttctaaga aagacaaaag ccggcgtctg aaatcaagac 3140761 agccggcttt aatatttctc atacatctct tgttttcttc gcttcgccaa cacatataaa 3140821 ccataaaaca acccaattcc aacagcatcg atgagcacat cccggataca accattcctg 3140881 ctgaagaaga gctgaagaac ttctgtgaaa aaagcaaacg caaatgagcc ggctgcagct 3140941 gatcttatgc tgccccgctg tttccacagc aaatatgtca gcacaaagaa ggaaaacgcg 3141001 tgtccgattt tttgaataaa cgcttcaggt acagtaagct cagtaaaatc cataactaaa 3141061 aattgagaca gatcagggtg cggctgaaaa tgaaaagcca ccgtttgcga tacgaccatg 3141121 ccgctgaagc tttccgtaca gacagaaagc aggataaaaa agatccagcc tgcgagcaat 3141181 aggcggttca tgacataacc tcctttataa cgtacgtgcc tacatgtaac tacatagacg 3141241 gtaaaacaaa gcaaaaagta acagaaaaaa acgcccatca caaggataga cgttttcttc 3141301 attaagactg ttcagtgtct tctgttgtgc tgctttcttt agaaccagat ttgtcagttg 3141361 aatcatcctt tttctcaccg gatttttctt ctgttccttt ttcagttgat ccgtcctttt 3141421 tctcggaaga ttgctgaatg gattcttctg tttcttgggt ggcagctttt tcaatagaag 3141481 aaactggttt gtccataaag tttaacggat tcattgcaac cccatcttta cggatttcaa 3141541 agtgcacgtg gtttccgctg tcttcactgt aaaggttctt gccagatttt ccgatcactt 3141601 gattttgttt tactttgtca ccttgctcta cgcttacttc ggaaagagat tgatacacag 3141661 tcgataaacc gtcggcatgt tctacttcca caacatatcc cagcactgga tctttttcag 3141721 ctttaacaac cgtaccgctc agagaagcag agacatcgaa atcttttccg tctttctcag 3141781 ctaagtcaat tcctttgctt aggctgtacg tgttattata ggtaacgagt gctgcttctt 3141841 tctcttcttt tgcggcatcg gtttcataga actttttcac aacagaaacg ttttcagaat 3141901 caacaaccgg cattgcgaca ttttccattg actttcctac ttcaactgca tcgtcgttgt 3141961 tgtcatatgc ggagtttccg ccgttatcag ccaactgatc ctttacctca tcatttgata 3142021 ctgattgata ccaaaggaca gctgttaaaa tgacggccgc actgactaag taaattgcag 3142081 ggaacaccca gcgtttacga aaaaactgct gaagtttttt gacttgagaa gttttctttt 3142141 cttcctctct cattgtttca tcacctcagc aacattctga acacttttct gaaaatatat 3142201 acaacctatc caaaaaaact tttttagatg tagtttgcac agactgaacg aaaatatgta 3142261 tttttttgag aggagtgcca aaaacgtatg aacatgacat tgcgtcttgc tgaacataga 3142321 gacttggagg ctgttgtggc gatttataat tcaacgattg cttctcgaat ggtaacagcc 3142381 gataccgaac cggtaactcc tgaagaccgg atggaatggt tttcgggaca tacagagtca 3142441 cgtccgctct atgtggccga ggatgaaaac ggaaacgtcg ctgcctggat cagctttgaa 3142501 acattttatg gaaggccagc ctataataaa acagcggaag tcagcatata cattgacgaa 3142561 gcatgccgcg gcaaaggtgt tggatcatat ttgcttcaag aagcgctccg cattgccccg 3142621 aatcttggca tccgctcact tatggccttc attttcgggc ataataaacc aagcctgaag 3142681 ctgtttgaaa agcacgggtt tgcagaatgg ggactattcc ccggcatcgc cgaaatggac 3142741 gggaaaagat acgatttaaa aattttaggg agagagcttt catgattagt ctggataaag 3142801 atgaaaacga aattgaacat cataatgaag aaaatagcct tgttgaacag gagactgcac 3142861 ctgttggaca ggagagccgc cagctgagcg cctccgctgt caagtcgcta tccgacattg 3142921 ccaagtgggg caaaatttct ggcatcttgt taatcattat gggatcgctt gtcactctgt 3142981 ctgttttgat gacagtgatt ggcgccatcc cgggcgtact gctcattatt tcaggcgtat 3143041 ttttgatgcg ctcagcaaaa gcagccgcgg aagccgaagg aaatctaacc ggcagcgctg 3143101 gcgaaagcat gcttgaaaat tacgggacat ttataaaaat gcagctgttt tatgcagcat 3143161 ccagtatcgt tactgtcctg atcgggatca ttgtagccat tttcgtgctg gtggtaatcg 3143221 gcattgctgc ttttgagaac acgccttcgt atgatgatcc ggattcttat tattatgagg 3143281 atgatccggt gtttgaataa tgatgagaca ggacagggca tgagttccat ataaacggaa 3143341 ccatgcctat tttatttgac tattcaaagc aggccggcgt aaacaccaaa tcctgaagca 3143401 agcatacaat agacatctct agtagaggaa atcaacaaag caacgctgtt acccagaaat 3143461 gaatatcaaa aaaacggatg aagtcggaat caatccgaaa ccgcactttt tatttcgggt 3143521 gtctgcatgc aaaaaaacac acccggatcg tctggaaaat ctcaacaatc cgggtgcaga 3143581 tcttctttaa tacatttttt tgcgtctgtc ttcctcagtc aaaaattcaa caaaactccg 3143641 catcgcaaaa ggctcttcct ttatttgtcg tgcgtaggag cttttccgct cttctgaaag 3143701 gatttcgctc tttttgatcc tgttcagcat atagatgtga accgtttttt ggatttgttt 3143761 atgctgatag cctgcctctt taaaaaatgc gagcccgagc gccgccaaaa gggcgaatat 3143821 gcctgcgctg atcagggact ccctgtcagc tgaagcatga aatagaaaag cagctaaatt 3143881 aaagagagag aatgcagcaa gcggaatagc aagaaaacgg taaatgacgg tttttttcat 3143941 gaaaggctgt acggcctttt gaattttttg catttctgtt ttgatgaacc ccggcatttg 3144001 ttcgactctg taaaagttca tataatcctc cccctttatt tgatgtttca agcttcacga 3144061 acgttatcat atgtgtttat tttaacgcag gtgcaagctg gttttaaaga aatctgcccg 3144121 tatttttcac gaagaatctg gatcgccgct ctttattctt ttaaaatgtg agtgttataa 3144181 tttgtaatgg gaatcagatc actgttattc atggaatact aatggcaatc ttcttgataa 3144241 atatgaatga gcggggttac aaagtgagta tttcttccat ccttttatca ctttttttca 3144301 ttttaaatat tcttttggcc atcattgtca tcttcaaaga acggcgcgat gccagtgcat 3144361 cttgggcgtg gctgcttgtt cttttcttta ttcccgtttt aggctttatt ttatacttat 3144421 tattcggcca taatctcaga cgcaagcatt tgtttcaatg ggaagaccgg aaaaagattg 3144481 gaattgaaag gctgctgaag catcagcttg aagatttaga aaccaagcaa tttcagttta 3144541 acaaccgggc aacctttgat aacaaagatt taatttatat gctgattatg aataaccatg 3144601 ctgtgtttac agaggataat tcagttgacg tcattacaga tggacgggat aaatttcagc 3144661 ggctgctgag tgacatttca aaggctaagg atcatatcca tttacagtat tatatttata 3144721 aaggcgatga attaggcaaa aaattgcggg acgctctcat ccaaaaggcg aaagaaggtg 3144781 ttcaggtcag agtgctttat gatgaactcg ggtccagaac gctgagaaaa aagtttttta 3144841 aagagcttcg cgaggctggc gggcatgtgg aggtcttttt cccgtcaaag ctcaggccga 3144901 ttaacctgcg gctgaattac cggaaccatc gaaagcttgt gatcatagac ggtatgaccg 3144961 gttatgtcgg aggctttaac gtcggagatg agtatctagg gcttaatccg aaattcggtt 3145021 attggcggga tacgcatatc cggctgcaag gaacggccgt gcacgccatc caaacacgat 3145081 tcatccttga ctggaaccaa gcttctcatc accatacgct gacatatatt ccaaatcact 3145141 ttcctgatta cggcccaaaa ggcaacgtcg ggatgcagat tgtcacaagc ggccctgatt 3145201 cggaatggga acaaattaaa aatggctaca tcaaaatgat ttcgaacgcc aagcgttcca 3145261 ttttgataca aacaccttat tttatcccag atgcaagcct gctggatgct ttaaggatcg 3145321 cttgcctttc gggcattgac gttaacatta tgattccgaa caagcccgat cacgcctttg 3145381 tatactgggc gacactttcg tatatcggcg atctgctgaa agccggagcc actgtctata 3145441 tttacgataa cggctttatt cacgcgaaaa ccatcgtggt ggatgacgaa atcgcttcag 3145501 tcggcacagc gaacattgat gtccgaagct tcaggctgaa ttttgaggtt aatgcattta 3145561 tttacgatat caccattgct aaaaaactgg tttcaacttt taaagaagat ttgctagtat 3145621 ccagaaaatt cacctatgag gagtatctgc agcgcccgtt gtggattcga ataaaagaat 3145681 ccgtctcgcg gctgttgtcg ccgatcttat aagatgcgta aacccccggc ctttacggcc 3145741 gggggttttc ctgatggtca cagtaaatga tgattgcctc ccgcaaaaaa gcggcaagac 3145801 cttctccata ttgattgatt gaatcggtaa atcgctcgtc agtgatatac acttccccga 3145861 gtcctctgaa aatgtcgagt gtgcaatcgt aatgatattg gcaaatatga tcgcgaaatg 3145921 cccccacagc ggcctgaatc tctgcatcat cgggcccatg cttcattcgc gccgcaattc 3145981 gtctgtaaat cgaatcaaat tcagccatga tcgtgcgcca atcatctgcc gagtatgcag 3146041 atgtcctttt ctctgtttct tctgcgattt cctttccata cagctttctg acttcatcag 3146101 cgtatgtctg ctggtgctct tcaatgtctt tcatgcttaa tccggcaaat aaatccctct 3146161 tattcatcgt ttcccctcca tcaacggaca aaagcgtcct gtcaattgtt tgaatcatct 3146221 catccattct ttgttttttc ttcatcaata tctccttttg cgactgaagt gccgctttcc 3146281 ggtcaaaatt cggatgatcc agcatctctt taatctcatc cagacgaaac ccgatttcct 3146341 tgaaaaataa aatctgttgc agtctttcca ggtctgcgtc actgtacaaa cgatacccag 3146401 catcagtaag cgctgaagga ttcagaagct caatattgtc atagtgatga agcgtccgaa 3146461 tgctaacgcc tgatatctcc gccacttgtt taacttgata tttcatacat aacacctcct 3146521 cttttttatc gtaaacaatc acgcaacgtt agggtcaatc cccaaaatgt tattttctat 3146581 atacaaaact tctcacaaat agtgtataaa agaaaagtga gtattttttt gtaaagggga 3146641 gccagtatac atgaatcctg aaacaatgaa caaaaccctc atcagcattt cgaaatgggg 3146701 aaaagctaca ggcattttat ttattattat gggcgcaatt accgcgcttt caggcgcgtt 3146761 cttttttcta atcggtgccg tgccaggcgt actgcaaatt atttccggta tctttttgat 3146821 gaggtcagct agggaagcag gccaaatggc tgaacacaat agcggacagt ctgaagactt 3146881 aatgctggag aattacgcga aattcgtaaa gatgcaaggg atttatttga tcgtaagcat 3146941 tgctgtatcc attcttgcga ttatcgcctt cttcatcttt ttaatgcttg ggattgctga 3147001 cggccttttc agcgatacgt acagcactta ttaatgagaa aaacccggag ctggctccgg 3147061 gttttttatt attccgcttc gcttaccact gtgaagcgtt catttttgtg ttcgggatgt 3147121 tcaagctcgt ccaacacggc aatggcataa tctgcatagc tgatatagct gtctcctttt 3147181 gcatttacga tgacattgtc ttttcctttt tggtaagagc cagtccgttt tcctgctgga 3147241 tcaaaaaatg ccgcaggact gaggaacgtc caggaaatgg agtctgtctg ctgcaaatct 3147301 ttcaggttct cgccttgatt tgatgcagtt ggcaaatatt ctttcggaaa ttccggcgta 3147361 tccattaaac gggttgtttt ggcttcatca acaaacaggc ttcccgctcc gccaacaaca 3147421 agcaatcttg tgtgcttcgc gtcctttaaa atgctgatga gtgctcttcc tgcttcaaca 3147481 tgaagatgtt cttggccggg tgctgctcca aaagcgttta cgaccgcgtc gaaaggcttg 3147541 atgtcttccg cagtcagttc aaacacatct ttttccaaaa tcgctacgtc ttgctcctgc 3147601 acttttgaag cgtttctgac gatggctgtc acttcatggc ctcttttttt cgcttctttc 3147661 aaaatctcgt ttcccgcttt cccgcttgcg cctataatac caattttcat ttttcatttc 3147721 ctccttattt gtaacaattt tagttacatg ttagcggtga gaagtcatcc cttttgatta 3147781 aaagagatga ttcataacat cttttaatga cttgcttgcc agttcatttt ccatcgctct 3147841 ttgcacactt tcaaacgttt catccagagc gttctgaatt tttttcccta ccggacattt 3147901 cggattcggg ttttcatgaa ccgcaaagag ttcttcttgc ttttggacag cccggtacac 3147961 ttctaaaaga gaaatatcag caggatcttt tttgaggctt gcacccggca ccccggcgcg 3148021 tgatgtgaga atatcagctt ttttcagcag gctgatcatt cttcgcacaa ctaccggatt 3148081 cgtgttgaca ctgtctgcaa tgatttctga agatgttttt tcatccatcg agatgaggga 3148141 taaaatatga atggcaacag caagacggct gttaatcatg ttttttcacc accgttgtaa 3148201 ctataatagt tacatttgat tcgtttgtca acatctaata tacactaaat acatgggttt 3148261 tgtgcaccgt ttttagtcaa tagaacggcc ggatgcactc cggccgcgtc ttatcaaaat 3148321 aagaaatatc tttgtccaag tgggacataa tcgacaggct ggcaagacaa ttcctccccg 3148381 tcagcaaaga cctgataggt ttttggatca atctcaatct tcggcaaagc cgaattcagc 3148441 ttcatatcca gcttgctcag ctttctgata tttttgactg gagaaatcct tttttccagc 3148501 cctaagcttt ccgccacacc acgctctatg cttgcctgag acataaatgt aatcgaggtt 3148561 gagcggttgg cttttccgta agacgcatac atttggcgca tgaaaaccgg ttcaggagtc 3148621 gggatggacg cgttcggatc tcccatttgc gcacgtgcaa tcatgccgcc ctttaagacc 3148681 agttccggtt tcacgccgaa aaataccggg tcccacagaa cgagatcagc aagcttccct 3148741 ttttccaccg agccgacctc atggctgagc ccgtgcgtaa ttgccggatt aatcgtgtat 3148801 ttggcaatgt accgttttgc gcgcacattg tcattcccgt tttcaccggc aagagcgccg 3148861 cgctgttttt tcattttatc ggctacctgc catgttcgga tgatcacttc accgacccgc 3148921 cccatcgctt gggaatccga tgatgtcatg ctgatcgcac ctatatcatg gagaatatcc 3148981 tccgcggcaa tcgtcgccgc cctgattctg gaatggctga atgccacatc ttcaggcact 3149041 ttcgcatcta aatggtggca gaccatcatc atgtcaagat gctcatccat cgtattaacg 3149101 gtataaggaa tggttggcgt tgtagatgac ggcagaatgt tcgcgtaaga ggcgagcttc 3149161 ataatatccg gagcgtgacc gccgcctgcc ccttcaatgt gataagtatg aataacccgg 3149221 tccccgatcg cgtcgagcgt gttttccaaa aagcccgctt cgttaatcgt atcggtatgg 3149281 atggcaactt gaatatcagc ctcgtccacg acttccatac acgttttaat ggcgcttggc 3149341 gtcgttcccc agtcttcatg gagcttaaga ccgatggcgc ctgcttccac ctgctcgatc 3149401 agcggcgctt tatcggatgc attccctttt cctaagaagc cgacattgat cggaaactcc 3149461 tcggccgctt ccagcatcct cgccatatac cacgccccgg acgtacatgt tgtcgctttg 3149521 cttcctgtag cgggtcctgt tccgcctccc aaaagggtcg tcacacctga agaaagcgca 3149581 acttccatct gctgaggaca aataaaatga atgtgcgtgt ccactccccc ggctgttaaa 3149641 attttgcctt caccggaaat cacctctgtc cccgctccga tgaccatgtg cggatcgact 3149701 ccatccatga tatcaggatt tccgcttttt ccgacaccga caatccggcc gtctttcaca 3149761 ccgacatccg ctttgacaat gcctgtgtaa tccaatagca cgacgttggt gataaccaaa 3149821 tccaaagcgc cgtccttccc tgtgattctg ccgttttggc ccatgccgtc tcggatagtt 3149881 tttccgccgc caaagatcat ttcttcaccg tatactgtga aatccttttc gacttcgatc 3149941 cataaatccg tgtcgcccaa tctgatttta tcgcccgttg tcgggccaaa cagttccgca 3150001 tattcctccc gtgacatttt catcggatta caccctccat ccagccggct tgttttaagt 3150061 tggccaacgt tttttctttg ccgcgttcat cgataaacgt gtcggccatt ccgttcagcc 3150121 ctctaattgt cttgcgtcct ctgatttcca ctagtgagac cgttttctgc tctcccggct 3150181 caaaacggac cgacgtgcct gatggaacat caagacgcat gccgatcgcc agctcacggt 3150241 caaataataa agccccgttg gcctccgcaa aatgaaaatg cgaaccgact tgaatggagc 3150301 gtgatccggt gttttttacc gttacctccc gtatctcacg gccttcatta atcgtaatgg 3150361 ttccctcagc aatttgaaat gctcccggct tcatgacttc acctccgcag aaattggctg 3150421 atgtaccgta acaagcttta caccatccgg aaatgtggcc tccacctgaa tgctgtccag 3150481 catctcaggc acaccctcca tcacatcttt ttccgttaat acatggcggc cggcttccat 3150541 cagctctgct actcccttcc catcacgtgc gccttccata ataaagcagg tgatataagc 3150601 agcagcctca ggatagttca gcagaacgcc ccgcgccttt cgctgtttgg ctaattcccc 3150661 cgctgcaaaa atgagcaatt tctcttgttc aactggtgtc agtttcatct gtagtcctcc 3150721 ttcttttgtc atataaagca gatgcggcta ctacgaattt gcggaacagt caggcgggac 3150781 atcacctccc tttcttcgag aatgggggtc atacggtaag atgcctttca aagcggcatg 3150841 ccgtttcttc atcagccttg ccatggtcaa caaccgttcc cctgtcgatc acggaaagat 3150901 cagattaacg cgttttccag actgcgctcg actaagataa caaatgtctt tttttctgga 3150961 aatttctata ataacttgtc tgactagttc gacaattaaa atctgaattc cttccaattg 3151021 tttattaagt aaaatatttt tcagatttac catcagcgct ctggtgattg caagctgctg 3151081 ctgttgaccg ccttttcgtt ttgaacaaac gtttgattaa aacaaatagc cccctctgtt 3151141 tagccggagt cggcctaata cagcgacaat ctgccccggg cgaagctaag gctgtgcaaa 3151201 accatcgatt gatcataacc agacgttaca ttcctgatgg cagcccgttg ttttgctccg 3151261 caaccggaag catggcatgg aggccagtct gaggcgccga cctccacgat accgagaacc 3151321 cgactattgc cattaactcc gcatcatgga cggtcacttc gctgatcgcc accgttcctc 3151381 ttaatgagtg aagaattccg gccttcactg aatccccgct tgtgtcgata tcaactgttt 3151441 tctcgcactc ccgtggcttc cgacactttc ttcggtgcag tacattccgt catcaaaacc 3151501 cctttgtttg atttcttcaa atgatgttat aaaagtttac aacttatgtc atcattatat 3151561 agaagaggcc tattaattca aagaatattt aaaaaattta gttaccttga ccaaatcagc 3151621 ttcttttttt gttatattta ttcacatcag aaaaagcgaa aaaaaaagac aagaaacatt 3151681 tcgtttcctg cctcttccgt acgattaatc tttatctgaa aatttatcct tggctttccc 3151741 gatatccttt tggatttcgc cttttgcctt atcttttttg ccttcagcct gcatgtccgt 3151801 tctgtcagcc atatctccga ctttatcctt cacttctcct ttggctttat tgaagccgcc 3151861 cttcattttg tcttttacac tatcgttacc catgttaatt ctcccctctc aattatgtgt 3151921 gtacttgtta acttcccgat ctgagaggca ataaacattc taatgttatt tatcgatttc 3151981 gtagcgctct ccgtaacgga gcaccttgta tatcgccagc ccgtctgatg actttttctc 3152041 cgaatatcgg accggcagca gggcaaaaaa cacataatac gtagaaaaat agacaaactg 3152101 atagaaaaac acattcggct ttaatacact gtgtataatc agcagattga ttgcaaaaat 3152161 cgtgatgagg ttaaacaagc agccccctgc atacacgagt gcatttgaga atcgattgtc 3152221 aattttcaac tccccgtacc ggcaaaaaga atcgataaaa taaatcgttc tgaaccgtat 3152281 gggtccaatt ttaagcagcg tttttcccat gcctatatcc aacgatccct ttccgccaaa 3152341 aataaaagcc ataaagctgt gccctgaaac atgtataatc tgtacaagcg gcagaacaat 3152401 gaggaaagac cacagaaact tcaccatatc attaaaacca aacattgaat tccccctcac 3152461 atgcatatct gcatcccaaa acggcttttg ttcaaaaaac agtgctgtag cgatttttcc 3152521 tgttctcccc ggaaataaac gttccgatgc tccccttttt ttgcataaaa aaaaaccatc 3152581 tgccagcaga tggttttgtc tcatacttca tataaacaat cgttcctttg aatcatctct 3152641 ctcatgctga ccgctttttc ataaaaatac accgcttctt tatattgttc gcgatgactg 3152701 aaataagagg cagcatctaa agcaaattct tcaatatata catacaggcc cttttcttcc 3152761 atataatcaa atacttcttg aatcatattc aaattgacag attccacata taatgcctgc 3152821 agaaatttat attttgccag actgaagaag tcgtttcgtt tttgggcaat ggcaatccct 3152881 ttttcatagt accgtatcgc ggcttcgcta tcttgttttt tgaaaagaac gcgagtcagg 3152941 ctgaagagcg cttttggaag ctgttccagc tgataatcct cgaagacagg aagcgctttt 3153001 tcaaagtatt cggcggcctg atccagctcc cccttgtcat catagcaatt accaatatta 3153061 taaagggctg atccgatcaa acggggctgt ccttccaata aagcaaggcg atacgcgtca 3153121 tctaaatgtt caagcgcttt ttcataattt ctgtagtcaa tgtagtttcc tgatatgacg 3153181 aaatggcatt gaattcttct gactctgtaa aaatcgtgag ccttatacgt ctccagcgcc 3153241 tgtacggcat ggttcatgga aaagtgcgtc tgcttcataa tataaaagac ttccgccact 3153301 ttaaaatgaa attccgctct ttcaatttca tcttctacaa acgcaagcat cttctcagct 3153361 ttccgataaa aggatatagc cgagatgtaa ttgttctgtt caaattcgta cattcctcta 3153421 aacaagtgaa aataatactc agataatccg gagatgctgt cctgattgct ttccagcgtt 3153481 ttgatcaatt cacgatattg aagctgagat tcctcgtgca ggtcaggctt tacataatcc 3153541 agcataattt ggtgccggta gctgatcagc tgataataca ggagaagcag ctgatcctct 3153601 tccatctgtt cgatatctag atcaatttct tctttcagtt ttacggcatc agccacttga 3153661 aatgctaaaa tgtgcttata ccacttattg attttcactc ctacttgaga tgacgggatc 3153721 tcgtacgcgg ccatgcccct ccaacccttt ctattttcta attggttata ttttatcata 3153781 atgtatggct ttggaattaa attttcttac aatgattcct tctttatgcc tatccttata 3153841 tatttcggtt tttctacgta ttttttgcac tcggattcta ataaaaaagc ttaccggaca 3153901 gtgccgataa gcttttgact tcaaattaac cgccaatata agacatttcc actttctttt 3153961 tgccagatgc ttttgatagc gtacgatcga ctgaatactg atcgatccga tttttccata 3154021 ctgtcccgat catttctgat agttcgtcat cacttaattc ctggcgaacc ggagctctga 3154081 ggtcaaatcc gcttgaagcg aataagcagg taaacagctc tcctctcgca gaaagacggg 3154141 ctctgttgca agatccgcag aatgcatcag atacagatga tatgacgcca atttctccgg 3154201 agccgtccaa gtagcggaat ctggaagcca cttcgcctat ataattaggc gctatcggct 3154261 caaccggcat gtgtttattg atcaaatcta tgatttccgc ctttgtcatg acgtctttct 3154321 tttcccattg gttggtgttg cctacgtcca taaattcaat gaatctcagg atatgccctt 3154381 tttctttaaa ataacgggcc ataggcagta tatctttttc attgacgccc ttttgaacga 3154441 ccatattgat tttaacaccg agccccgctt gcttcgccgc ttcaatgcct tccagcacct 3154501 tgctgacaga aacaccgcgc ccgtttatct tcttaaaacg ctcgtcttct aaagaatcaa 3154561 ggctgatcgt aacccttttc agcccagcct ccttgagcct cttagcataa acaggcagca 3154621 gtgatccgtt tgtcgtcatc gcgatgtcac gaatacccgg tatgcgggcc agttttttga 3154681 ttaattccgg catatccttt ctcatgaggg gctctccgcc ggtcaagcgg attttttcaa 3154741 cgccaaatct tgtgacaaac aatgtcgcaa gccgttccag ctcctcaaat gaaagcagct 3154801 cctctttctt taaaaaagga taatccgggc cgaataattc ggcgggcata cagtacgtgc 3154861 atcggaagtt gcagcggtct gtaacagaaa tgcgaaggtc tctcagcggt ctgtttcttt 3154921 tatccaacat ctgacgcgac tctgtaatca tagctacagc cccttcctac tccctgattc 3154981 tctcagggtg tgtatataca ttaaatgatc cgtttctgac aaatccaatc gctgtgatat 3155041 tcaattcttc agccatttga atcgcaagct ccgtcggggc cgatttggaa atgacaatcg 3155101 acacgccgat tttggccgct tttaacagga cctctgatga gattctgccg ctgaacacaa 3155161 tcagtttgtc gcgtacggac atcccgttta gaaggcagtg tccgtatagt ttatcaagtg 3155221 cgttgtgccg accgatatct gtgcgcatca acagaagctt ctctgtgtcg caaagcgccg 3155281 cattatggac gcctcccgta tcctgaaacg tcccgctccc ttgctgcatg tctttcataa 3155341 gcgccagaca tgcctcaggc gatatcttga tttggctgac agccgtcttg gctgttttga 3155401 catcctgctg aaaataaaaa tgacggccct ttccgcagca tgagccgatc acccgtttcg 3155461 tataatcctt ttgatccaat gtctcagggt gaacgaggtc gacatataca aaaccgagac 3155521 tttcatctat tgtaaacctt ttaatttctt tttgaaatcg tataacaccc tctgatgcga 3155581 gaaatccgat gacaagctct tcgatatgct caggcgtaca aacgagcgtc acaaattcac 3155641 tgccattcag tatcactgtc aaagggaatt ccgtcaccat ccggtcttct actttgctta 3155701 tttccccttg ttcatagcgc catacatccc tgaccgcagt tactttatcg ttcaatgtct 3155761 cttcccctcc gcaatgttcc tgcctttata ttttttcaca ctcctcggat tttgtcgaat 3155821 tctgagacac aaaaagagcc ctctatataa agggctttta caggatgtga tgacggcggt 3155881 gtttaggcag gacgcctaag catttagccg ccgttccttt tataacacgt gagcaccaat 3155941 gtgcattgac aacgaacgcg gggtttgtcg acacgctgag acacctctgt ataaaggact 3156001 ctatgtttga ttatgctgat tctttttcag aaccgtaaac agcacaatag ctgcgatcaa 3156061 ggtgagaatg ctgacaaaaa agaaggctgc cagttttaga agaacaccaa gcaatataaa 3156121 tgcaacggtg gctataagaa aaatcattcc gaataatttc atatgttcaa ccccttttta 3156181 gggtatcatt cccgcccaaa ctgtttttaa accaataaaa aaggcgcctg ggggagcgcc 3156241 tgatctttag gttccttact cagtaaattt ttgtgcttct ttttcccaag cctgttcgaa 3156301 ctcatccgca ctgttcgctg aaatatattc tccgccgcca gcgacagctg cttgtttcat 3156361 ctcttcatta cccttgacat caaagttgaa gccaatgatg tttacaatcg tatccacatt 3156421 tgatgcacgg agcttttcga tttccgccgc agggtctccg ccgcacgttt cttcaccgtc 3156481 agtgattaaa tacaccacgt ttttcccgtc tgcgtcaaat gcttcaaatt cttttcttgt 3156541 gtctgcaagt gctttggcaa tcggtgtcca tccagtcggc ttgagctcac tcaatgaatt 3156601 gtcaaacaga gacccttcat atggatgaag gccgtaaatg gtttccgtcg tactgcacga 3156661 aagggcttta ccggacagtt tattgttccc tgcatgcccg aaaacgcgaa gcataagatt 3156721 tgtatccttt ggaagaagtt cggcaaaaga ttttactgat tttttggcaa tgtctatttt 3156781 gcgctctcct cctgtttttt gaaccatgct tccgcttccg tcaaacaaaa cagctacatt 3156841 tgtatcagcc tgtttctcag cggcaaaaga cggggaggca atggaaacag tcaacaatcc 3156901 aatgataccg gcagccagca attttttcat atgattactt cctttctttt tcatattttc 3156961 caactatatg ttggattctt ctttatgcta gaatacgaaa atgcaaaaag atataggaca 3157021 tgctgccttt tgtgctgctt tcacgatctg tccaaaatcg cttgaaatgc cgttcatttt 3157081 tagccatttc cgcccagaaa gcataaacag cttgtgtgat cattcattct tttttcgcct 3157141 tgattatgac agaaaaacgg aaatctgcta ctatgctaca ggcagacagc taattagttt 3157201 tgaagttttt gttacataca aaaagaggct gaccatcacc agcctctttt ttcttattta 3157261 gataacatta gtgattgctg agtgaaaatt ttctcaacat ctttttgggt ataagccggg 3157321 aagtattcac cgccgcctac tttcgcaatt gcgttcagct ggcctttgta tccctcttta 3157381 taatcaaagc cgatcacatt aacagtgata ttgtcttttt gcagttcctt tgctgtttta 3157441 atcgggtttc ctccgcacgt ttcctcaccg tctgtcaaca gatacaccac tttttcccct 3157501 tttgcatcaa gctggtcaaa agaagatttc gcctcgttca gcgctttggc aattggcgtc 3157561 cagccagtcg gcccaattgt attgagagaa ttgaggaagc tttgctcgtt aaagctttgg 3157621 aagccgtata cgttgcgaat ggcttcacat gactgaactt ttccggaatt tttattgttt 3157681 ccttcagagc caaacacgct cattttcacc tgagttcctt ctggcaatga gctcgcaaac 3157741 tttgaaattt cttttttggc tgaattaaat ttagatacac catctattct tttcgccata 3157801 cttccgctgg catcaagcaa gaccgccacg ttcgccggcg ctttagcctc cgtttctgtc 3157861 ttttcagctg caaaagcagg tgaagttaat ccaaaaagca atcctgtcat catgatcagt 3157921 gaaaatcttt tcttcatgtt cgtacccctt taccaatttg tttctgcgtg cagatgttca 3157981 acgctgaaca taatctatcg taatcaacaa aaaccgagaa ataaataggg cgggcttccc 3158041 cattgctgtt gtttactttt gcatagaaac ctatgttttt attagtgatt tccacctaac 3158101 gcccctatga aaagagaaga ttgtccgcct ttcggctttc gttatatgag tctgtcgaag 3158161 tctgtcgaca aatgtggatg actttaccac aatctcaaag cctgaaatca ggaaaaaagg 3158221 actgatcctt aaagacggtc agaagctcct ctaaaccgtt tcagctactc ttagataaaa 3158281 gatattcagg aacagaaaaa gacgcccaat gagcgtcttt ttctactttt tcgccatata 3158341 tttattcaaa aacgcatctg cctcagaaat ttgtgtgcct tggtaatagt actttacaat 3158401 gtcatcaacc gttttgcctt ctttggccat aaaattcgct ccgtattggc tcatccccac 3158461 accgtggcca aatcctctcg tcgtgactgt aattgtgtct ccatttcgct tccattcaaa 3158521 atcggcggag ttgagaccca acttttcacg tatgtctctt cctttcagcg tcttgccgtt 3158581 aatgacggca gttgcgacct ggtggcccgg tgtctcgccg gtaatcttcc ctactgcgct 3158641 agatccatcc agcttgacgc caagcttttg ctgaaattct gccgctgtaa aggttttcgt 3158701 tgccttatat ttcggagact ttttatccca tgggcttttg acgcttttta aatatgggat 3158761 agcacttgtc caataagctt ctgcattctc tgtgtagccg ttgcttgtgg agaaaaagga 3158821 tgcttcaatc ggctggttgt tgtacgttaa gattttgcct tgcgtactgg ctaccgcatc 3158881 tgtgattttc ttcagttttg tctcatagct tgtgccccac tgttttttca gctccgcttt 3158941 gcttttatac acctggaaca tctgtgtatc atccaccagt gagcctttag gagcttctac 3159001 cgctgaattt gacaccatca gtctgacaat aaatgttctg gcggcaagcg cctgggcttt 3159061 cagcgcttca ggtttaaagg ttgccggcat ttcggaggcg acgactccaa tcacatactc 3159121 ttcaagcgga atgttttcta cggattgatt tgcggttcga tagacgggaa tagaaacagg 3159181 tgatgctttc aatgtttctg ctcctttcga tgctggtttc gtgctgactg ctgtcttttc 3159241 tgattctacg ctggcccccg cttccttatt atgctggaat ggtataacca agagtgtggg 3159301 aaccaagaga atcaatgcac atagtacgga tagtgtgatt gcgaattgtt tcatattcag 3159361 ctgcctcctg ctcgggattc gactctagtc tagtctatgg gcagggacaa gctaatatga 3159421 ctctcgtttt ggacagaaac tttatttgtc atttacgtat tcttttttgc tattttgcgc 3159481 ataatgatga taatacacaa aaaataaaaa accagtatgc cagagtgaca tactgatttt 3159541 caagtaagtt tatgcattta agtcagaaac gacttcttta ttctcttgct cagaagcaga 3159601 ctcatcattt acacgttcga tgtctgcgcc cagagcggca agcttctgat ggaaatcaac 3159661 gtaaccgcgg tctaagtgct tcaattcagt aacacgtgtg tgaccttcag ccactaaccc 3159721 cgcaagaatc agcgctgcac ctgcacgcaa atcagtcgct gcaacttcag ctccctgaag 3159781 ctgtacagga ccgttaatga tgacagaacg tccttcaatc ttgatatcac cattcatacg 3159841 gcggaattct tccgcatgca taaaacggtt ttcaaaaacg gtttctgtaa tcatgcttgt 3159901 gccgcttgca cgaagcagaa gcgccatcat ttgtgactgc atatcagtcg ggaagcccgg 3159961 gtgaggcatt gttttgatgt caatcggttt aagctctttc gggccgatga cacgcagacc 3160021 ttcaccttca tccttaattg ttacacccat ctcttccatt tttgcaatta aagaggtgag 3160081 gtgctcagga accgctcctt ttactaatac gtttccttca gtgattgcag cagcaaccat 3160141 aaatgtgccc gcttcaatac ggtcaggaat aatatggtgt tttacgccgt gaagcttttc 3160201 gactccttca attttgatgg tgccggtgcc agctccgcgg atttttccgc ccatgccgtt 3160261 gatatagttt gctaaatcaa cgatttcggg ttcttttgcc acgttttcca gcgttgttgt 3160321 tccttcagct agagcggctg ccataatcag gttctctgta gctcctacac ttgggaagtc 3160381 cagataaatt tttgcgcctt gcagtcggcc ttttacttca gcttcaatga agccattacc 3160441 gactttgatt tctgcgccca ttgcttcaaa accttttaaa tgctgatcaa tcggtctgga 3160501 accaattgcg catccgcccg gaagtgcaac tcttgcatga cctgtacgcg caagaagcgg 3160561 ccccatgaca agcacagacg cacgcatttt acgaacatat tcaaaaggtg cttcagtttg 3160621 caaagcgtat gaagcattta cagtcacttc attattttca aaatgcacat ctgctcctaa 3160681 atgacgcaac acttcgttaa ttgtatatac atcggagagc gtaggtacat cacaaattac 3160741 gcttttttct tcacttgcta ataaagatgc agcgataaca ggtaaaacgg catttttagc 3160801 gccttcaact ttgactgtgc cgtttaactt ctgaccgccg cggacgatga ttttttccaa 3160861 ggtattcccc tccgcgtccc taaattctct atattaatat tcagtcgtaa cgattggtgt 3160921 gccaaccgta acggtatgtt ttccgcccat tcctgcactt ctaagtgcaa tttgcaaatt 3160981 cattttatgt ttcgaggtca taatgtactc ttcccactca tctgtaaacg cagaaataga 3161041 aacgaaattt ggctcaacta catgttctac tgatcttgct tgaaattcat ttaataactg 3161101 atttgctttt ttttgcaaaa caatattcat attatcatct aagtgaccat ttagacaagt 3161161 aaaaataact actttttctt ggaatatccc aagtgtctcc cgttcaaact gttcatatgt 3161221 atcattccag ctatccggtg tctctagact catttgctca tataataaat acgaagttgg 3161281 attgtgtttt ttgagggttg tgacaagctg cagtctaaaa gaagtacgat tttttttgtc 3161341 agtatatgtg ccaattgcct ttatcatttt atcttcccgt gcaatcaccc aatcatattg 3161401 acgatactct tgttttaaac gttgcacttt ttgataaaat tctttttcgg tcagtgacaa 3161461 gttttgtttt gcatgcaatg tccacttatc tattgacaca tcttgacgtt ccatcccctc 3161521 tgccatctgt gctaacggcg ttaattcact cgcatgaatg gtatggaaaa cagcaatgac 3161581 gaagcttaac atgacggaaa tgataatagc gtggcttact tgttttttct tcatgttcat 3161641 ctctccccct tatccccagt tttaccggag gcaagaggcg ccatacgtaa aaatcttcgt 3161701 caaaactcga gctattcgct tcaacccgct tctcccaacc atttaataat gttcaaaacc 3161761 tattaaaata gatagggaag ctgctgtgaa taattgaggt aatctaaaaa gaaattggca 3161821 acggccgttc caatggcgat tgtcagcaaa atcatcagga gtcttgcctg cacgactttg 3161881 ccttttttga ttaacggatc tatattgacg gcttgcaacg cccaccaagt cactgctata 3161941 aaaatcaggt gaacgacaat gccgattgca gcctgctgtc ccaatacact catctattac 3162001 actcctttct ctgcgttcat accctttctt attatataag aagcacagat aaagatgata 3162061 cattttatac agaacggaat aatcagccaa atctagggct aatccccgct taaagtgcga 3162121 ttcttttaca tggtatactt tattggaaag gagctggcaa atgtgaatca ttcttttttt 3162181 cagcctgaaa agcaatatgg tgaggacctg ccaatttttg atcaggaatg ggaagcaatt 3162241 gcattctatt atgattatag acagtcacag attgaagaac tgaatgaatt gtgtcagttt 3162301 tttaacattt ctcttaccta tacgagagaa agccttgaag agcttgaaaa cctctatttt 3162361 caaagtatac aagaactttt gcttgctgat tggaatcttc ctattgaaga attcgagaaa 3162421 atgatcagtg tttatcttat agattgtgtg attgcccgcc atgaagatgc tgaatgggtt 3162481 gtaaaacctt atccctataa agacggcgct tatacacttg gctttagaag acatcgcaaa 3162541 tcgtggcata caatgaatgc ctgtgatggt ttatacctgc gtccaaaaga ggatcgcccg 3162601 ttgctgtcgc tgtttgattc tcttgtgcgt tcataaaaaa atccttctca taaagagaag 3162661 gattttttct tatttccctg ctacatccaa tctgttcaaa gcccgctgta acgcaagctc 3162721 agcccgacga atgtcagtat catctgattg agaattcaaa cgctcctgcg cccgctggcg 3162781 tgcagcttca gcgcgctctt tatcgatgcc ttccgctgtc tcggcagcct gggcaaggat 3162841 ggtgacatga tcaggacgga cttctacaaa accgccgctg acggcaacca tttcagtctg 3162901 cccgtctttt ttcagacgga cagcgccgat tttaagagga gccacggttg gaatatggcc 3162961 tggcaaaata ccgagatcgc cgctttcggc tctcacactc accatttcga tatccgcatc 3163021 gtatactggg ccgtcgggag taacgatatt gactttaacg gtcttcatgc ttttaccctc 3163081 ctaggaccag attaaacttc tacacccatt tcttttgctt tctcaacaac ttcttcgata 3163141 cggcctacaa gacggaatgc atcttctgga agatggtcat atttaccggc taagatttct 3163201 ttgaagcctt gtaccgtctc ttttacaggc acgtaagaac ctttttgtcc agtgaactgt 3163261 tcagccacgt ggaagttctg agaaaggaag aactggatac gacgtgcgcg gtgaacgaca 3163321 agtttgtctt cctcgcctaa ttcatccata ccgagaatcg caatgatatc ctgaagctct 3163381 ttgtaacgct gaagcgttga ctgtacttca cgcgcaaccg catagtgctc ttctccaaca 3163441 atttcaggag caagggcgcg tgatgtagat gccaacggat caaccgcagg gtaaataccc 3163501 atttcagtta atttacgctc aaggtttgtt gtcgcatcca agtgagcgaa cgttgtcgcc 3163561 ggcgccgggt cagtgtagtc atcggcaggc acgtagatcg cctggataga tgtaactgat 3163621 ccaacgttcg tagacgtgat acgctcttgg agctgaccca tctcagttgc aagcgtcggc 3163681 tgataaccaa ccgctgaagg catacggcca agaagggctg aaacctctga acccgcttgt 3163741 gtgaaacgga aaatgttatc gatgaagaac agtacgtcct gtccttgtac atcacggaag 3163801 tgctcagcca ttgtaaggcc tgtcaaagca acacgcatac gtgcgcccgg cggctcgttc 3163861 atttgtccga ataccatggc tgttttgttg attacgccag agtcactcat ttcgtagaaa 3163921 aggtcgttcc cttcacgagt acgctctcct acgccggcga atacagagat accgccgtgc 3163981 tcttgcgcga tgttgttgat taattcctgg attaatacgg ttttacctac accggcacca 3164041 ccgaacaatc cgattttacc gcccttaatg taaggagcaa gcaaatcaac aactttaata 3164101 cctgtttcaa gaatttcaac ttctgttgaa agctgatcga atgaaggcgc ctgtctgtga 3164161 atcggatcct ttttcgcatc cgcaggaacc ggctcattca aatcaatatt ttctccgaga 3164221 acgttaaata cacgtccaag tgttacatca ccaaccggta ctgagattgg cgctcctgta 3164281 tctacagctt ccataccgcg ctgaacacca tctgtagatg ccattgcgat tgtacggact 3164341 gtatcatcac ctaaatgaag agcgacctca agcgttaaat caatacctac ttcgttttca 3164401 cttgcagctg gctgtgaaat tttaatcgca ttataaattt caggcaagtg accgtcttca 3164461 aaacgcacgt cgacgaccgg tcctaatacc tggctaacgc gtcctttctt catcgctatc 3164521 cctcctgaca aaatctttct attctaaagc ggctgctccg ccgacaattt ccgtaatttc 3164581 ttgtgtgatg gctgcttggc gagcgcggtt gtaagaaagc gaaagtgaat cgataagttc 3164641 cttcgcgttg tctgtcgcgt ttttcatcgc cgtcattctt gcagcgtgct cacttgcttt 3164701 actgtcaaga agcgcaccga agattaagct ttctgcatat tgaggaagca aaacctccag 3164761 aacctcctct tcagatggtt caaattcata agacgccgtt ctttttccgc cgccgctgcc 3164821 caaatcagat aacggcagaa gttttttctc cgttacttct tgagtaatgg cgctgacaaa 3164881 atggttataa acaaggtgca attcatcaaa cgcaccgtct ataaacattt gaatcgtttg 3164941 acgggcaaga tctttaattt ctgtaaacgt tacttcatct ccaagtcctg ttaactcgga 3165001 aatgatcgga atctcccgtt tcttaaagaa atcacggccc actcttccga tggcaatcac 3165061 cgcatactca tccttagact gatgacgttc ttgcatggcc tgataagcac tccgtaaaac 3165121 cgaactgtta aaagcgccgg caagaccgcg gtcagacgta atgacaaggt atgccgtttt 3165181 tttcacttct ctgctgagaa gcatcgggtg cttcacgttg ccggaaactc ttccgacgtt 3165241 tgacacaacc tcttggattt tatccatata tggcacaaat gattttgcat tgttttcagc 3165301 acgattcagc ttagccgcag ataccatctg catggctttt gtaatctgac ttgttttttt 3165361 cgttgacgtg atccttgact taatatcgcg taatgaggcc aaagatttca ccaccttttc 3165421 tcttcatctg cgtaaaaaga gagaaaaaga gaaccttttt ctctcatcag cattcgagtt 3165481 agttgcttgg tgcaaatgtg cgtttgaagc cttcgattgc agctttgaag tcttcatcag 3165541 caggaaggtt tcctgttttc gcaattccgt caagcaggtc tttatggttt tggtcaaggt 3165601 acatgtagta ctcttcttca aaacgtctga tatccgccac aggaatatca tcgagatatc 3165661 cttttgtcag cgcataaaga atagctactt gcttttcaac cggaagcggc ttgttcagat 3165721 cctgcttcag cacttcaact gtacgcgcac cgcggttcag ttttgcctga gtcgcttggt 3165781 cgaggtcaga accgaattga gcgaatgctt ccagctcacg gtatgacgca aggtcaagac 3165841 gcaaagtacc tgatactttt ttcatcgctt tgatttgcgc tgagccgccg acacgggata 3165901 cagacaatcc ggcattgatc gctggacgta cgcctgagaa gaacaaatca gattgcagga 3165961 agatctgtcc gtcggtgatg gaaatgacgt tcgtcggaat ataagcagag atatctccgg 3166021 cttgtgtttc tacgaacggc agagctgtaa ttgatcctgc gcctttcgcg tcgctaagct 3166081 ttgctgcacg ctcaagcaga cgggaatgaa gatagaatac atccccaggg aacgcttcac 3166141 ggcctggcgg acggcgaaga agcaaggaca gctcacggta agcggccgct tgtttagaaa 3166201 gatcatcgta tacaacaaga acgtgcttgc cgttgtacat aaattcttct gccattgtaa 3166261 ccccagcata cggtgccagg tacagaagcg gtgccggctg tgacgcagac gccgttacaa 3166321 caattgtata atcaagcgcg ccgtgtttac gcaatgtttc tactacgccg cggactgttg 3166381 attctttttg gccgatcgca acatatacac agatcatgtc ttggtctttt tggttcagga 3166441 tcgcatcgat cgcaacagat gttttacctg tttgacggtc accgatgatc agctcacgct 3166501 ggccgcggcc gattggaatc agtgcatcga tcgctttgat accggtttga agcggttcat 3166561 gaacggattt acggtccata acgcctggtg cagggctttc gatcggacga gttttgcttg 3166621 tcagaatcgg gcctagtccg tcaaccggct ggcctagcgg gtttacaata cggccgatta 3166681 actcttcacc aacaggaacc tccatgatgc ggcctgttct ttttacttcg tctccctcac 3166741 ggatctcact gaaaggtcct aagatgacga tacctacgtt tgattcctca aggttttgag 3166801 ccatacccaa aacaccgttt gaaaattcga caagttcacc ggccatacag ttgtcaaggc 3166861 cgtgcacacg tgcaataccg tcaccgactt ggatgactgt acctacgtct tgaacttcaa 3166921 tatcagattg ataattttgt atttgctgtt ttatcagcgt gctaatctct tcagctttga 3166981 tgctcactta ggtttcaccc cttctatcga ttttccccgg ctaattgacg ttcaatgcgc 3167041 tgaagcttcc cgcttacgct gccgtcataa atccggtttc caatgcggac tttaataccg 3167101 cctattaaat ccgtctgcac ttcatttctg attctcagtg aagcgactcc ggcttttttt 3167161 gcaaacactt gtgataatgg taacatttct gcatccgtca gcggtttcac tgaatatacg 3167221 attgcgtctt ctgtttgacg ggccacattt gcgagtttga taaactcatc tgtgagctca 3167281 gggacaatcg cggcacgatg gcggtcaatc aaaagaaaaa tcgtattgag tacggactgt 3167341 gacaaagagc caaatgcatt ttgaatcagc tcttttttct tcgcagccgg caccttcgga 3167401 tggttcaaca catcattaag cgctttttca ttttgaaata cttgttttac aacaattagc 3167461 tcttcttcta cttgattcag ctgagcggac tcattggcta tatcaaaaag agctgatgca 3167521 tatcgtttag agacagctga tccactcatc ggctttctcc tacctcttta agatagtcct 3167581 ggatcaattt ctcttgcgct tgttcatcca gttctttttc gatcactttc gacgcaatca 3167641 tgacagaaag agacgctact tgctcacgga gagcagaaac cgcctgttcc ttttccttca 3167701 cgatttcagt tcttgctgct tctttcagac gttcagattc tgcacgtgca gcctgaataa 3167761 tctcttcttt ttgcttctct cccagtttct ttgcgttttc gataagagtt tgggattcct 3167821 gtcttgcttc ttttaaaaga acgcgctgct cttcaatcag ctgctgcgct tctttatttt 3167881 tttcttcagc agacgtaatt tctccagcga tgtggtcttc acgctgtttc attatgttta 3167941 atagcggccc taaagcgtat ttcttcagaa gcgctaataa gattaacata gctaacagtt 3168001 ggaacaggat atctccgccg ttaaacgaca atcctagttc aagtggtaat tgagacatct 3168061 actacggcaa ctcccttctg caggtttttc tttgctgatc cagcagccgc acttgtctct 3168121 tttcagccgg caaggcggga tgcttatcag acataaagca atggcgaagg ttctcttgga 3168181 atgatcttcg ccatttttag ttcatataag gcttttatgc ttagccaaag aacgctaaga 3168241 atgcgataac gacagcgata ataggaaggg cttcaactaa tgcgataccc atgaacataa 3168301 gagttctcag ttctttacct gcttccggct gacgggcaat cccctctacc gtacgtgaaa 3168361 caatcaaacc gttaccaata cctgcaccaa gtgcgcctaa accaattgca atcgcagctg 3168421 ctattaaatt catgaaaaag ttcctccttt aaaatgttat ccgtttggat ataatgtttt 3168481 aatgatcatg actgatttta tgagacatgt acaccatcgt cagcattgta aagataaatg 3168541 cctggatagc accaataaat aaactgaatg cttgccatgc cagcatcggc agaatggcac 3168601 cgattgtacc gacaagaccg agagccacgc tttgcgaata atggcttgtt gctaatcccg 3168661 caagcaggcc gagaagaatc tcaccggcga agatgttacc atacagccgc aaacctagag 3168721 tcagcgtatt cgcaaactct tcgatgattt tcatcgggag catgaatgga acaggtctta 3168781 aatagtcttt ggaatattcc ttgagccctt tcatcttcac accatagtag tgggttaaag 3168841 caacaaccat cacggctagc gttaatgtaa tggcaggatc ggctgtcgga gacttccacc 3168901 agagctcatg tccgattgta atagagaacg gcagccccag catattcgac acaaatatgt 3168961 acatcagcaa tgtgacacca agtgccaaga agttagcccc tgtttttaaa tccattgtac 3169021 tgccaataat attgcggacg aaatcaacaa tccattccat aaagttctgg gcttttccgg 3169081 gacggatcga aagcgttctt gtcgtcaata tagcaatcaa taaaacaatc acactcgcca 3169141 cagtaatcat cagaatgttt gtcagattaa aagtaagacc tagaaattct atagttctgt 3169201 aaccatgatt caaagggttt tcacctctct tccattgatg aacgtttaag ctggataaag 3169261 gaatctatca taatgacagg gtatattgtc attaatccaa taactgtact tgccatatga 3169321 aagtattcgg gatttttata ggcaacagcc acagcaagaa tcgcattgca ccaccgcgct 3169381 gcgctcccga gagatcgtat ggactttcct ttctctacag ctctgtcaaa agcattcatt 3169441 cttctgacga gcagtaaaaa attaaacaaa ctgaaaacag ttcccagaat aaggcctaaa 3169501 aaaacggttt tatacgctgt taaaccataa cccagtacat acactgccaa aatgaacaat 3169561 aaatatttgc gttgtctgct aaatgtaagc ttgggatcgt ccatcaatta tctgtctcct 3169621 gatgaaaaaa taatgtatag cttggatacg gcaaaaatca gcggttaacc cttagtagaa 3169681 gacctttttt gaccggcaaa acgggcctgt tcgaaaaaat cattcatccg caagccttgc 3169741 agggatgctg tttcattcgc ttaaataaat cctcataata cgggtttgct gagaggattt 3169801 acattgagga tgaggactat aatgaaagct atgaaaacct tctcataata ccctcgttta 3169861 gcatacaata gcccctaaca tgtgtcaatc tgtttaaagt taaaaaactt tttatacttt 3169921 acgtctccac agaatgttca cattttcacc tataattgta tacagattca ccgaatagca 3169981 aaaaactgga taaaaaaatg aaaccccctt ttggggattt cattttttat tttgttccaa 3170041 acatgcggtc acccgcatct ccgagacctg gaacaatata tcctttttca tttaattttt 3170101 catctagcgc cgcaatgtaa atatcaacgt ccgaatgatg cttctgcaat tcttccacac 3170161 cctccggcgc tgctacaaga cacatgaaac ggatattttt cgcaccgcgt tttttaaggc 3170221 tgtgaatggc ttcaactgcg gaaccgcctg tagcgagcat cgggtcaacc acgatgaatt 3170281 cacgctcttc cacatcagaa ggaagcttga catagtattc cacgggtttt aaggtttctg 3170341 gatcacggta aaggccgaca tgtcccactt ttgccgcagg aatcagcttt aaaatgccgt 3170401 caaccattcc caatcctgct ctgaggatag gaaccactcc gagttttttc cctgagatga 3170461 ctttcgattt cgcagcctga accggtgtat tgatatccac ttcttccaga ggaagatcgc 3170521 gggtaatttc aaatgccatg agtgtagcca cttcatctac taactctcta aaatccttcg 3170581 tacctgtatt ttcattccgt atatatgtca gcttgtgctg aattaaagga tgatcaaata 3170641 cataaacctt tcccatactg tgtttcagct ccttttttat tgtcccatca acaattacac 3170701 acttctattg attctacaaa aaaagacatt gagtttcaag aacatcgtca aaaaacccgc 3170761 cgggcataag cccaagcggg ttttaggatc ttaataatct aattctttat ataaaggaaa 3170821 tttatcagtc agagcagcta cacgctgtct tgcttcttca agttttcctt catcttcgtg 3170881 gtttttcaat gcaagcgcaa tgatagcacc gacttcttct aatgcgtctc cgtcaaaacc 3170941 gcggctggtt acagcagctg taccaagacg gatgccgctt gttacgaaag gtttttcagg 3171001 atcatatgga atcgcgtttt tgttagacgt aataccaatt tcatcaagta catgctccgc 3171061 aaccttacca gtcagtccga gcgaacgaag gtcaacaagg ataaggtggt tgtctgttcc 3171121 gcctgaaacg agctggatgc cctctttcgt taaggcttca gccagacgtt tcgcgtttga 3171181 aatgacgttt tgtgcatatg ttttgaaatc gtcctgcaat acttcaccga atgaaacagc 3171241 ttttgcggca ataacgtgca tcagagggcc gccttgaatt ccagggaaga tcgatttatc 3171301 aattttcttg ccaaactctt cacggcaaag gatcataccg ccgcgaggac cgcgaagtgt 3171361 tttatgtgtt gttgttgtaa cgaaatcagc gtaaggaacc gggtttggat gaaggcctgc 3171421 cgcaacaagt cctgcgatat gtgccatatc caccatgaag taagcgccga cttcatcagc 3171481 aatttcacgg aatttcttaa agtcgattgt acgaggatac gcacttgctc ctgctacgat 3171541 aagcttcggt ttatgagcga gggctttttc acgcacgtca tcgtaatcaa tatattgagt 3171601 ttctttatct acgccgtact caacaaagtt atattgaaca ccgctgaagt tgactgggct 3171661 tccgtgtgtt aaatggccgc cgtgggagag gttcatccca agtacagtat cgccttgctc 3171721 caaaatcgtg aagtacactg ccatgtttgc ttgtgcgcct gaatgaggct gaacgtttac 3171781 atgctccgct ccaaagattt ccttcgcgcg gtcacgggcg atatcttcaa cgacatcgac 3171841 gtgctcgcat ccgccgtagt agcgtttgcc cggatatcct tctgcgtact tatttgtcaa 3171901 aacagatcct tgtgcttcca taaccgcttc acttacaaag ttctcagaag caatcaattc 3171961 gatcttagtc tgttggcgtt cacgctcatt tttaatggcg ttaaacactt gttcgtcttg 3172021 cgcaggtaaa tgtttcatca gcgagatcct ctcctatccg tatcctgttc tttgttttta 3172081 ccatcactat tgtacatggt ttttaaggcc gatgtaaaag attattttta aaaaatctaa 3172141 atttttattg gtaaaaacga atattaataa cttaaattta atttaaagtt cggaatttat 3172201 ttcactatct taaaataaaa gaaaagactg gctatgcagt cctttcattc gcactcataa 3172261 accgcccgca ctccgccgat tagtttcggc cgtgtacgcg ccaatgtcac atgagctgaa 3172321 ccgaggctgt tttgagagac acgcacaggg acagccaccg gtttcagatg catgccgata 3172381 aacgtatcgc ctatatcaat tccggcgtca gcctgaatgg tttcaacaag aacaggagac 3172441 ttcatctgct taaacgcata agacgccatc gctccgcccg cttttggaac gggcacggca 3172501 gaaacggttg gaagcctgaa cagcttggct gtttctgctt cgacgacaag cgctctgttt 3172561 aaatgctcgc agcattgaaa cgccagatgg attcccgttt tttcccggag ctcagcaagt 3172621 ccgctgtaga tgctttcagc gatatctaca ctgcccgatg tgccgatccg gctgccggcc 3172681 acttcgctcg tgctgcatcc aaggacgaag agctgatctt gtttcaattc cgcttggtcc 3172741 tgaaactcag acagcatcgt cttccacgtt tgtttcaact cattcattaa acagcacccc 3172801 tacaggtttt tctcttcata atcggagatt tttccaatac gcgtttggtg tcttcccccg 3172861 gtaaactcag tagtcagcca gatttttgcg atttcccgag ccaaaccagg tccgatcacc 3172921 cgttcaccca tcgcaaggat gtttgtgtca ttatgctccc tcgtcgcctt cgcgctgaag 3172981 gtatcgtgcg ccagcgcgca gcgaatccct tttactttat tagcggaaat gctcatgccg 3173041 atgcctgtcc cgcaaattaa aatgcctctg tcaacttcgc cgctaaccac tttttcggcc 3173101 accggaaaag cataatccgg ataatcgaca gagccgctgc cgcagtcaca gcccatatca 3173161 atatattcaa tttgcaattc gtccattaac tctttgattt catttcgaat gtgaacgccg 3173221 ccatgatccg atgcaatggc tactttcatc tgcttttcct cccagcgtgt gtgatgcggc 3173281 ccgcccgctt tattgaccgc gcagcctgtc cgctctttga ttcacaccat atgatgtgct 3173341 tttcactata ttctactcct tcacgcagga tttgcaaatg acctgtttgc agattttctg 3173401 acaacttatc tacggtcttt tttcagctgt tttgccagct gccgaagaag ctcttcaagc 3173461 tcatctcgcg tttgtttata gatgtcaatt gagccgccga acggatcgag gacatcacca 3173521 tggctgcctg tgacatattc ttttaacgta aacactttat cacgataacg tccaaattgg 3173581 ctggcaatga tctgtttgtg ctgatgggtc atagccagaa ccaaatcagc cgattccata 3173641 agttcttcag ttaatggaga agacacatga ttaagggcaa tgtgtttttc aaacagcgct 3173701 tcgactgcat gaggcgtcgc tttcccatta ggtgaagcaa acacgcctgc cgagcggaca 3173761 ttgacattca gcccttccct ttctgcaatt gatttaaaaa gcgcctcagc cattgggctg 3173821 cggcacgtat ttccagtaca gacaaaaata atatccatgt cagtcacccc ttatttttct 3173881 ctattatata tgaagaaaaa agaaacggcg acttcgtttc ttttattggt atattaaatt 3173941 ggcaaaagca gctttaatcc aaacacgatt aatatgatgc ccccgagcgc ttcgctgtat 3174001 gtgccaagcc atgactgcac ttgttttccg accagcaggc ccagccatgt caacatcatg 3174061 ctgaacagcc cgaacagggt aattgtgagg agcggatgcg agccgtatat ccccaagctc 3174121 aagccgacgg aaaagctgtc aaggctgacg ccgatggcaa acagcaataa gcccggccct 3174181 gccggtgaca tgaatcgttc ttctgactgt ttaaaagagg ccataagcat ttgaacccca 3174241 agaacaaaaa gcagcgcccc accgatataa accgctaaca cgccgaggag ccctgacagc 3174301 atgttaccgg ccgccatccc tgcgagaggc atgatgacgt gaaagaggcc gatgatgaaa 3174361 ccaatataga atatctgctt ctttctaagt ttgaccatgc ccattccaag gccgacagaa 3174421 aaagcatcca tccctaaagc aaacgccatg atgcttaatg taatcagttc gcctataaac 3174481 aaatccgaca tacataaata acccccttgg acacgccccg cttttttagc ctatgcgtgt 3174541 ccaaaaaggg ttagaacatc tgactgcttt cagcgaatca ctcttcctcc ggcggctttc 3174601 atcagcctgt tcataatagc aagaccgaca cctgtatccg gaaaggattc cgctataatg 3174661 aaatccacct tattctcatc aaagctgcgc aaagcatcat acagccctgc cgcaacagtc 3174721 tcaagctgag cccgtcttcc gcagctcttc acataatcag cggaataaac gcccgctttt 3174781 tcttctgtcg tcaggacacc gacccgtctt ccaccctgtt gatattcttg aatgaggtgc 3174841 tgaatgcgct ctgggctgcc ttcgcaaatg gcaagaggcg ctgtcggcgc ataatgtgta 3174901 tatttcatcc ctggagaaat cggcttctcg ttttggtcgc tgagcccttt atccacatgg 3174961 atcggcccga tcaccgcttc aatttgttcc ttcgtaatgc cgccaggacg caagagaaca 3175021 gggatgtcgt ccgcacatga aagcacagtt gattcgaccc cgattccggt agggcctcca 3175081 tccacaatac cggctatgcg gccatccaag tcgtgagcca catgctccgc ttttgtggga 3175141 cttggcttgc ctgatagatt ggcgctcggt gctgcaatcg gcagtcccga ttcgcgaatc 3175201 aatgcaaggg caagcggatg atccggcatt ctaatggcaa ccgtttcaag acctgccgtt 3175261 acacgaggtg aaagcgcatc aggtttgcaa ggcagaatga gcgtaagtgc tcccggccaa 3175321 aaccgtttca tcaatgtttt cgccttttcc ggcgccgggc ccgttaaatc ctcaagctgg 3175381 ctgatatccg caatgtggac aatcagggga ttatcgctcg gccgcccttt cgcctcatat 3175441 atttttttga cggcatccgt attttttgcg tttgcgccta ggccatatac tgtttctgtc 3175501 ggaaaggcaa cgacctcatt ttctcggagc aaagcggctg cttgtgcaat ttgtggatca 3175561 tttgtggata actcgtcagt tacatccaca aaccatcttt tcgttttcat ttctgaccaa 3175621 actccttatt cacaacaata aaacgattgt tttacgcgtg taatcctttt gaaagtataa 3175681 aagatgtcct gtaataaaac aagcgttatc cacaaattgt ggacaacgct aataaagaag 3175741 tggataagta tgtgtataaa ctgcacttat ccagacgctt ttttcatcaa aacggctcct 3175801 tctgtttgcc gcgattcaca gaagtgatca gaagaaaaca gctcctccgg tacactctca 3175861 gctctttcaa aacccatggc cgtcagaaag tccgcagagg aatgctgatt tgctactagg 3175921 tacacggttt tgatctgatg cttttcgcac agcacctcca tgctttgaaa aagcgtgacg 3175981 atgtggcctt ggtgaagctt gtccgatatg acaagtgatc gcagcagccc ctggtcacag 3176041 cttatttttt caataccgag gcatccggca atgtttttct cactgtcctc cagcataaga 3176101 aattgagtga agccttcttt cacgccttca tagctggttt ttgcctgttt taaaaatgcc 3176161 tcgagcacat ctccgtcttt ttcccttgcc acccgcagtt gataaaacat ccgttcaccc 3176221 cgtttttgcg ttctttcttc caatctatga ggcaaatcta tttttagacc agatgattag 3176281 gaaaaaaggt cggaaatcca ttcgactaaa aagaatttca cttctgtgcc gtcttctttt 3176341 tcttcgttct cttctttttt ggctttttcc gctttagcgg ttacgtcctc aagcactttt 3176401 tcagtctgct tttttgaggc ttctttatct tcttgttctt tgacggcttc cccgttagaa 3176461 aaatcaagaa agcagagggg cgggaacagc acacaccacc agttggcgcc gtctccgttt 3176521 ccaagcgtaa tcaaaatcgc ttcatactca ccagcgggat ataccatgtt gccgtaaagc 3176581 tttgtcggaa acgagatttt gtcaaaatca acggatatcg actgattcgc tccttctttc 3176641 tccattgttt cctttgcaat tgctttgatt tcaggcagct ttgaacgaat cacgcgacgc 3176701 gcttcttcaa tagaagtaat atcctttacc caagttgtga tttctttatt caccgcgtct 3176761 cttatatgac gttttaattg ctggtcttga tcactatcgc tgtttgccag tattctcaaa 3176821 cgaatcgcct gatcaggtat gaccaccggc tgattttccg atttttgtgc cgtctcttct 3176881 tttgccagcc ctacgagcgc tccggataat aaaagaaaga tatatataca aatgattact 3176941 gtttttttca tcggtcccca ccgttcctct ccgtgctttg tttctagccc tattatggac 3177001 aaggagagcc tgggataaac gtgcagggtg aaaaaaatct agcaagctgt taatcttatt 3177061 tatggtacga tagtgtttta ggaggtttaa gatgaaatac aattatacag tgctgttatc 3177121 agcattcacg atgtccgttc tttattcagt aatttatatt cattcattta tcattgccgc 3177181 tctcatcaca atggcatttt attttctgtt tccttatttg atcttcgcac tgccgcttca 3177241 aatcatgatg aataaaaagc cgaaacgttt cagccctttg tatctgctgt attaccttgc 3177301 cgctgctttt attgccaacg cgatcatttt cggcatgctt cagccttcgg gacaatctct 3177361 gtttcaaaat acagcctttt atcttttcgc tgtattaaca gctcttatct attggatatg 3177421 ggattctgtt ttactgcaaa aaaaggaagc ctaagaggct tcctttttta ttaaaacaaa 3177481 atcgtcagta aataacatag aatggaaggt atcgccgcaa caaagaaagc ggccgccatt 3177541 ttcatgcgag atgtacggcc ttctttggtt tctgaatggt agtttgcccg ctgatcgctt 3177601 ccgcttacag ccaaacccga tgtaatgatc gcgagcccca ctaaaacgag agacgcaacg 3177661 ccaaaaatcg cttcatatga aagagcctgc ggaaaaatgg tgccaatcat gctctcaatc 3177721 gcaatgagca ggattcctgc tgtcagggcc tttttcatgt ttacatcccc tttgctggtg 3177781 ttaaacagct tgatccattc actcgccagc aagctgctta tttattttta tgaatcagag 3177841 cgcatatggt tctgtctttt ccattaatat ctttcagcac ttccacttcc gcccccttaa 3177901 acgccttgag gatcaggtct ttgaccgccg ctccctgttt ccagccgatt tcaaaaacga 3177961 caaatacttt atccttcata acaagcggaa tgtcttccat aaaccgctta taaaatttca 3178021 gcccgtctcc gccatcggtg agtgcgtgca gcggctcatg aaaacggaca atttccgata 3178081 aatcagccat ttcttcctct gaaatatatg gcgggtttga gacaatgata tccgcttttt 3178141 ttcccgcctt aataaaaggc tcaagcagat cgccctgata aaagcgcaca ttcgctccga 3178201 gtttttctgc attggcagag gcgacttgca gcgcctcttt cgaaatatcg accgccgaca 3178261 cagaaaagct ttggttttca agcgcaagcg tgacggctat tgcgccgctc cctgtaccaa 3178321 cgtcaacaac ttcgagcttg ccgtcttcag aaaaaacact ccgatatttt tcaagcaaat 3178381 gaaagacaac ttcttcagtt tccggccgcg ggatcagcac atcatcattc accataaatt 3178441 cccgtccata aaaaaactct tttcctataa tgtattgaac cggcacgccc tctttatgca 3178501 tctcaacgtg acgcttaaag cgatacagtt cgtcttcacc aatcggttcc tgtaagcttg 3178561 cgagcagctt gcttctctcc attccggtat cataaagcaa taggagctcg gccgcatttt 3178621 cttctcttcc cgcttcggtt aaataagaag aagcccattt cagggcttcg aatatcgtct 3178681 tcatcttaac cttccgactg ctgaagcttg cttgcctgat cttcaacaat cagcgcttca 3178741 accacttcgt caagttttcc ttcaagaatc tgatcaagct tttgaatcgt caaaccgatt 3178801 ctgtgatccg tcacacggtt ttgcgggaag ttgtatgtgc ggatacgttc agagcggtca 3178861 ccagatccga ctgctgattt ccgtgtttga tcatattcag cctgggcttc ctgctgaaat 3178921 ttatcataga ttctggcacg gagaaccttc attgcttttt ctttgttctt aatttgagat 3178981 ttttcatcct ggcatgatac aacaacacct gtcggcaagt gagtcagacg aaccgcagac 3179041 attgttgtgt taacgctttg tccgcccggt ccgcttgaag caaatgtatc gacacggata 3179101 tccttctcat ggatgtcgac ctctacctct tctgcctcag gaagacatgc cactgttgca 3179161 gtggatgtat ggatgcgtcc gcctgattct gtttccggaa cacgctgtac gcggtgggcg 3179221 ccgttttcat atttgagttt agaatacgcg ccgcttcctg taatcataaa gatgatctct 3179281 ttgtagccgc ccgttccggt tacattcgct tccatgacct ctgttttcca gccctgaagc 3179341 tcagcataac gggaatacat tctgtacaga ttgcccgcga ataaagcggc ttcctcgcct 3179401 cccgcagccc cgcggatctc catgataacg tttttgtcgt cattaggatc tttcgggatc 3179461 aggagcacct tcagccgttc tgacagtgtt tccgtttcct tctgaagttc agaaatctct 3179521 tccttcacca tgtcgcgcat ctcagcatcc agcttctctt caagcatcgc ttttgcatca 3179581 gccagctgtt ctgacgcatc tctgtattgt ctatatacgt caactgtttc ttgtatatca 3179641 gattgctctt ttgaatattc tcttagcttt ttcggatcgt tgactacttc tggatcgctc 3179701 aaaagctcat ttaatttctc gtatcgttct tcaattgatt ttaaacggtc taacacggtc 3179761 ttcacctctg ttttcctgtg cgtaacattc tcattatagt atagtgatta accccagtca 3179821 aaagcatttc aatcccagct ggaaaagctc cctctgctat actggaattc gaggagggat 3179881 gatgttgctg aaatccatac atcatattgc aatcatatgt tcagattacg aaaagtcgaa 3179941 agctttctac gtacataagc ttggttttca ggtgattcaa gaaacgtacc gcgaagagcg 3180001 cggctcctat aagcttgatt tgtcgcttaa cggctcgtat gtcattgagc tgttctcgtt 3180061 tcccgatccg cccgaacgac aaacccggcc tgaagccgca ggcctgcgcc acctcgcctt 3180121 tacagtcggc agcttggata aagctgttca agagcttcat gaaaaaggaa tcgaaacaga 3180181 gccaatcaga acagatccgc tgaccggcaa gcgtttcacc ttcttttttg atcctgacca 3180241 gcttccatta gaactgtatg aacaataaca gtttttgaag aaaaaaagga gatacccact 3180301 ttctttgccg aatcttttct tgttttgtct aacgggaagg gaaccgcatt ctatggtcga 3180361 atacctagct taaaaggagg tatgggatca tgaatacaaa tatggtagca agtgaactcg 3180421 gcgtctccgc aaagacggtg cagcggtggg tgaagcagct gaatcttccg gccgaacgca 3180481 atgagctcgg acactattcg ttcacggcag aagacgtgaa ggttctaaaa tccgttcaaa 3180541 aacaaatctc tgaaggcacg gcgattcagg atattcatct gccgaaaagc gctaaaaagc 3180601 gcacaggctt ccttgtccaa aaaacaagta gcgacacaga acgaagaatc gagcagcttg 3180661 aacaaaagct ggacaccctt ttacagcaaa ggcaggacga aagcgaattg atggcaagga 3180721 tgtcggaact ggaacgccag ctgaaacaaa aagccgatga aggtgtatct taccagctgc 3180781 ttcagcaccg cagagaaatc gatgatattc ttgcagatct gcaatcactg acctcacaaa 3180841 tgaaagaatt caccgctcat tcgatccccg agactgctgc tgcttctgaa aaaaccaaaa 3180901 caagaaaaaa accgctgctg tcactgttca aatttcaaac ctaaagcaaa aagctccctt 3180961 aaagggagct ttttttgtta cgcagtaagc gcgataatga ttggaagtga aatcaatgac 3181021 agaatcgcac tgaccacaaa cgcagttgca gtttcttctt cttgtttctc gaaacgagtc 3181081 gcaatcatgg ctgcaacggc agaaccaggg aatgcaacaa gaaggattgc ttttgttgtt 3181141 tggtcagctg gaagtccgat agcaagagca atcaggaaca ttaacgcagg ctgaaccgca 3181201 acttttagta acgcaatacc gatagccggc atactgagtt taattttacg aataccaacg 3181261 gtaacaccaa cagcgaagag agcaacacca gatgttgtgc ttccaagctg atcaagcatt 3181321 ttaacaccca gctcaggaag agtgaaattg aaaaccagca ccaagatcat actgattaac 3181381 ggagcagctg caagcggctc acaaagacca tgcaggattg attttcctgt catcttccag 3181441 aagctgtcgc cactctcttc gtttttctta gaagactcac caacagtagc gataatgatc 3181501 gcgagcggat caagaatcgc gttaaccacg atacctgtga ccgcgatcgg aatcgcaact 3181561 tcattcgctc cgaataagct tcccaatacc gggataccca taaatgcgaa tgtcggctgt 3181621 gcagagttca aagaaaatac agatgagttc gttaaatcat acttgaatat aaatctgcaa 3181681 accaaaagaa tgatgatata gaaaccaaca atcccaataa ttaaagaaat cattaaaggt 3181741 acttgtgata aaaattcact tctggaagtt gtcaaaatac cagcgataaa gtgagctgga 3181801 agtgcgtatt tcgttactaa cgtacttacc ccttttgccg acttggcatc ataacttcca 3181861 aaatgtcctg caaaccaacc cagcacgata acaaagaaga tcggcgccag gaggattaag 3181921 atatctaaga tgctcaaaat attctcctcc aaatcctatg tccgtatact ttagctttac 3181981 aaaaagcttt ccctcggaca gaaaaattta ctcgctaatt atttcgcgat gacttttttg 3182041 tattcaggtg tccacattgc atcaagtacc gcttgtttca catcttcagg ctgacgattt 3182101 gccacgccgt ctttaattgc tgcttcagca acggcaatcg caacttggat agaaacctct 3182161 tgaagcttat caatgcttgg aagcaatcct gctccaggtg tttcaagatc aaccatttca 3182221 gcaatcgcat cagcagttgc agcaaacata gcaggtgtaa tgatacgcgc ttcagctaca 3182281 attgaaccaa gtccaagacc agggaacgcg aatgcgttgt tagattgtcc gatttcataa 3182341 gaaacaccgt tgtattctac attgtcaaat gggcttcctg ttgcaataag cacttttccg 3182401 tcagtccatt tgaacagatc ttcaggaaca gcttcagcaa ggtgagtcgg gttagacatc 3182461 ggcatgataa ccggacggtc tacgtgagat gccatttctt ttacaatttc ctctgtgaat 3182521 gcacctgaaa cccctgaagt accaatcaag attgttggtt tcgcttgacg aacaacttca 3182581 tcgaatggaa tttgaccttt ttcatcgcgc ttccagtctt tcacttcatc cgcattgcga 3182641 aggtaaggtt tttggaaatc aaggatgcct tcgatgtctt cagtcagcaa gcctctgtaa 3182701 tcaagtgtgt agaaacgttt gttagcttct tcttcagata atccggctag caccattgtg 3182761 tcacggattt ggtcagcaat accgatacca gcagaaccag caccgaagat aacaacacgc 3182821 tgatctttaa tagaagcgcc ggttttcttc atagcggcaa gcacacctgc aagtgtaatc 3182881 gcgccagtac cttgaatatc atcattaaat gtcaggattt catgattgta ttttttcatg 3182941 atgttgcgtg catttttgtt gccaaggtct tcccagtgaa gaagcgcttt agggaagaat 3183001 ttcaatgcag cttttacata agcgtcaatg aaagcttcgt agcgttcacc ttgaacacgt 3183061 tcatgcttgt taccaatata taaaggatcg tttagaagtt tttcgttgtt cgtaccgaca 3183121 tcaagcacaa ccgggataac acggctaggg tcaataccag ctgcagcagt gtagacagcc 3183181 aatttaccga ttgcaatatt aataccgcct acaccccagt caccgatacc gagaatgctt 3183241 tcggagtcag tagcaacgat aagatcaata tcgcctgctg tcgcatgaag gttttcaaac 3183301 gctttttcaa taccgtcaat gttatcgatt gacaagtaga ttccttgagg tcttctatat 3183361 tcatggctgt attcctgaat cgcttcacca actgttggcg tgtacacaac aggaagcatt 3183421 tcgcgaagat ggtttttcag caatttatag aaaagaactt cgttacggtt tgcaagatca 3183481 cttaagtaaa cattttgacg aaggcggtca ggctgcgctt ggaattgctc gtacgcgcgt 3183541 tgtgcttgtt gatcaagaga aagtacagtt ggcggcagaa gcccttctaa gccgagttct 3183601 tgtctttctt ctagtgaaaa agcaacgcct ttatttaaag taggaataga taaaacttct 3183661 tttcctctaa gagttgtttc taagtggcct tctttcgttt tttttatgtt attcaagcaa 3183721 atctccttct ttcttgaaat agttaaccaa gttaagtaat aacccatcta aaatatgacc 3183781 gatcatgatc tttatgcgac tttgtgacaa ttattcgaac aatgtctcaa aactatttac 3183841 attacgtaag ctattgtatg cctgtcaaaa tcaaaattca agagaagaaa attacttaat 3183901 tttttaatat acttatttaa attttttaat tgaatattat cagaatataa aaaaaacacc 3183961 ggtgttttta gccggtgcat tctatcttta tacccatgtt ttggactatt ttttagattt 3184021 acctgggact tcgtgatgat gtctgcatct tgcttcatat gattcagctg caccaaccaa 3184081 aatgaccgga tcatcgtaag aagcaggttt gccgtcaatg aggcgctgtg ttctgctcgc 3184141 cggtgatccg caaacagaac agacggcttg cagctttgtc acactttccg caatcgccat 3184201 gatattcggg acgacaccga acggctctcc cctaaaatcc atatcaaggc ctgctgctat 3184261 cacacggtag cctttatcgg caagagatga taaaacctca acaatttcct gatcaaaaaa 3184321 ctgcacttca tcaaccgcaa ccacatctgt actttcactg atgtgatccc aaatgtccgc 3184381 agcagacgaa atggcatagc tcgtcatcga tgttccatta tgggagacaa cagcagcttc 3184441 gctgtatcgg ttatcaatta caggcttaaa taccctgact tcctgcttgg cataagttgc 3184501 tctcttcact cttctgatca gctcttcaga tttccccgag aacatgctgc cgcaaatcag 3184561 ctcaagccac ccgctttgtt tcattatgta cataggcttc gctcccctct ctctgccagc 3184621 tgtgttttag acaatataaa aaacaggcaa gactgctgct tgcctgttga gaaatctatt 3184681 attacttaag accgtatttt ttgttaaagc gatcaacacg accatcagca gaagcgaatt 3184741 tttgacggcc agtgtagaat gggtggcatt cagagcaaat ctcaacgcgt acctcttctt 3184801 ttactgagcc tgtttcaaat tcatttccgc aagcgcattt aactgttgct tttttgaaat 3184861 taggatgaat tcctgctttc attgtatcca tctccttccg ccctgaatcc cgtgtggaaa 3184921 cagagttatt atttcggagc attgtccgaa acgcatatga gaaaattata tcagtgattt 3184981 acttcttttg caaatacaat ttaccttctt gcagatgata gatttgcctg tttccattct 3185041 tgattgagaa tatcgaaaaa ttcctggttt gttttggttt ttttcatttt tctcatgaac 3185101 ttttctgcga aatcaggtga atcagacatc gttttgcgga tagaccataa acgatcaaga 3185161 tgctctttag gcacaagcag ctcttctttg cgcgttcctg aacggcggat atcgatggca 3185221 gggaagatgc ggcgctcggc aagagagcgg tcaagatgga gctccatgtt gcctgttccc 3185281 ttgaattctt cataaatgac atcatccata cgtgaacctg tatcgaccag agccgtagca 3185341 aggatggtta agctgccgcc ctcttcgata tttctcgcag ccccaaagaa gcgtttcgga 3185401 cggtggaacg ccgctgggtc aatccccccg gaaagcgttc ttccacttgg cggaatcact 3185461 aagttgtagg cgcgggcaag acgtgtgatg ctgtccatca ggataatgac gtcttttttg 3185521 tgttccacga gacgcatcgc acgttcaagc acaagctcgg ccactttgat atggttttcc 3185581 ggcacttcat caaacgttga gctgacgaca tccccagcta cagagcgctc gatatcggtt 3185641 acttcctcag gtctttcgtc aattaaaagc acgatcagct ctgcttcagg ctggttcgct 3185701 gtaatgctgt tggcaatttc cttcagcaac atcgtttttc cggctttcgg cggcgcaaca 3185761 atcaatccgc gctgcccaaa tccaaccggc gccatcatgt ccataattct tgtagacaag 3185821 aagttcggct ttgtttcaag caccatttga cgatccggat aaagtggcgt aagagccggg 3185881 aaatgcacac gctcttttgc agattcggga tcatccccat ttactgcttc aacgtgcaaa 3185941 agtccatagt aacgctcatt ttcttttggc gggcgaacct tgccagatac tttgtctccg 3186001 ttccgcaaat cgaaacggcg gatttgtgaa gctgagatgt aaatgtcttc tgagcttgga 3186061 gagtagttga tcggtctcag gaatccgaaa ccttcagact ggatgatctc gagaacgcct 3186121 tccataaaca gcagatcttc ctgttctgca ttcgctttca gaatggcgaa aatgagttct 3186181 ttttttgtca gtttgctgta ataggagatt ttataatgtc ttgcaagttc ataaagctct 3186241 ttcaatttca tattttccaa agaggaaata gatacgtctt tcataaaaac accacgcttt 3186301 tcatagtcaa tatcttactc tgaacatgtc atctgctgct tttgcacaac atccgccaaa 3186361 gcacattctt tttttaacat aaaggaactt ctatcggtaa cacttccacc catgatcggc 3186421 gcttttgtta aaaggattgt cttaatgagt tttgaaggaa gcgaggacaa aaacatgaga 3186481 agatcaatac ttatatcgtc tgtatgcggt agaaattgaa actttcctag tgcttaaaag 3186541 aaggtattac gcagtaaaat tcgcagcact ctttattttt accttatttc aaaaaattat 3186601 tcaactgaaa taaggttttg acacggaatt gatagagttg acgcttttct gcaaaagtta 3186661 aagcgggctc acacccgctt tttctgtttg ttatggacgg attacaagat ttggtttctt 3186721 tttcaagctg tgtctgccgt caacgaaacg aacagtgccc gattttgcac ggataactaa 3186781 gctttcagtt gtaccgacag agcctttgaa ttgaactcct tttaacagct cgccgtcagt 3186841 aacccctgta gctgcaaaaa tcgcgtcatc acccttcaca aggtcttcca tgcgaagcac 3186901 tttgcttaaa tcaaggccca ttttgtgaca gcgagtgatt tcttcttcgc tttgcggaag 3186961 aagtttacca atgatttctc cgccgagtgc ttttagcgca acagcggaaa gcacaccctc 3187021 aggagcgccg cctgatccga acaggatatc aacgcccgtg tggtcgaaag ccgtgttgat 3187081 ggcgcctgcg acatcgccgt cattgatcaa tttgattctg gcgccggcct cacgaagctc 3187141 ggaaatgatt tttgcgtgtc tttcacggtt taaaattgtg gcaacgacgt cctcaacgtc 3187201 cttgtttttc gcttttgcca ccgctttaag gttgtcaatg acaggtgctt cgatgtcaat 3187261 gcagcccacc gcttccggac cgactgcgat tttttgcata tacatgtcag gagcattcag 3187321 aagcgtgcca tggtctgcga ccgcgataac cgtcagcgcg ttccagccgc cgcttgctaa 3187381 gatgtttgtg ccttcaagag ggtcaactgc gacatcaacg cgagggccgt acccgtttcc 3187441 gagtttttcc ccgatataca gcattggcgc ttcgtccatt tccccttcac cgattacaac 3187501 ggtccctttc atcggcactg tatcaaaaac gtctctcatt gcacttgttg ccgcttcatc 3187561 agcctcatct ttttttcccc ggcccatcca tcttgctgat gccaatgccg cagcttctgt 3187621 cacacgtacc aattccattg ataaacttct ttccatttca acacgatctc ctctcacaag 3187681 aaaccattat gaattttgaa gctgttctat ttcttcgtca gtcattcttt cacgccaaat 3187741 tgtcgctcca agcccctcaa gcttcttctc aaggctgctg tatcctcggt caatatgctc 3187801 cagtcccgta atttccgtga cgccatcagc catcagtccg gctaccacca agcaggctcc 3187861 ggcacgcaga tcactcgcct tcacttttgc gccttgaagc tcgacaggac ctgtgatgat 3187921 ggcagatctg ccttctactt tcatattggc acccattcgt ctcagctcat caatgtgctt 3187981 gaatcttgcc gagtagatgg tgtctgtgac gacactcgtc cctttcgccc ttgtcaggag 3188041 cgccgtcatc ggctgctgta aatcagtcgg aaaccccggg tatacgaggg ttttgacgtc 3188101 aaccggcttt aagttcttct gcccgccgac aatgaggagc tggtcgtcgc ttgtttcgat 3188161 atgatagccc atttctctca gctttgccgt taacgactca agatgagtag ggatgacgtt 3188221 atcgataatg acttccttgc ccattgcagc ccctgcaatc ataaatgtcc cggcttcaat 3188281 tctgtccgga atgatcgtat gcttgcagcc gtgcagttcc ttcacgccgt cgattcgaat 3188341 cacattggtg cccgcacctt tgattttggc gcccatgctg gtaagcaatg tcgcgacgtc 3188401 aatgatctca ggctccttgg cagcgttttc gatgatcgtt ttcccttctg ccaaaacagc 3188461 ggcgagcata atgttaatcg ttgccccaac gcttacgaca tctaaataaa tccgtgcgcc 3188521 tctcagcctt tcagctcgca aataaatggc gccttgttca ttggttactt cagctccgag 3188581 tgcttcaaag cctttgatat gctgatcaat cggacggggc cctaagtgac agccgccagg 3188641 caatccaatg accgcctgct tgaagcggcc gagcatcgcc cccattaaat aatatgacgc 3188701 gcgaagcttt tttactttcc cgttaggaag cggcatgctg atcatcgacg tagggtcaac 3188761 aaccatttcc ccattctcaa aatgcacgtt gccgccgatt tcctttaaca ggtcacgcag 3188821 cgtttcaata tctgaaatct ctggaagccc ttcaattgtc acctcggaat ttgccaaaat 3188881 ggttgcaggt attaacgcaa cagcgctgtt tttagcgccg ctgatatgta ctgtaccgtt 3188941 taacgagtca ccgccggcaa tattcaactt ttccatgata gtctccttcc ataagaagat 3189001 agctgcggag ctaaataaaa tgtcatttta ttctgtctct gcaaataaag ctcatgtcca 3189061 aaatctagcc aattcgaaga gaaagaatac aacacattgt aaaatatcag gaagaaaata 3189121 gcgaagcttt ggggggtaca ggtttcaaaa gatgcacaga gacccgccgg ctcgagagac 3189181 atcgtcgtca tccggcaaaa gcagtacgca tacccttcat tccgatatca gcttctgcag 3189241 cccaatgatt ccttctctgt aaagcggcgt cagcatctga agatccgctg tatcaggtcg 3189301 gtgaaataca aaggccgcgg caaacaggca taaagctgtt tgccgcccct ttcattattt 3189361 gttccagtct gccaggaatt gttcgattcc tttgtctgtt aacgggtgtt tagtgagcgc 3189421 atgaatgact ttcagcggca ttgtgccgat atgagcccct ctaagagcag cttctgtcac 3189481 gtgctgcgga tggcggattg acgctgcaat gatttgcgtg tcaaggccgt gaatgtcaaa 3189541 aatctgttta acttctgaaa tcaggtcaag cccgttgtgg ccgatgtcat ctaaacgtcc 3189601 caggaatgga gatacatatg ttgcccccgc tctggcagca agaagcgcct ggttggcatt 3189661 gaagatcaat gtaacgtttg ttttgatgcc taagtcagta agtgctctta ccgcttttaa 3189721 accgtcagac gtcattggga ttttcaccgt aatgttcgga gcgatcttcg ccagttcttt 3189781 tccttcctcg atcatttcct cagctttcaa agaaataacc tctgcgctta cagacccttt 3189841 cacgacgtct gtgatctcgc gaagacggtc gtggaatgat acgttagctt cctttgctac 3189901 taaactagga ttcgtcgtta caccggcgag aattcctaat tcattcgctt ctctaatttc 3189961 atcgatattg gctgtatcaa caaagaataa cattttcaaa aagcctccct gattaagaaa 3190021 ttttctgaac tgcgaatatg attgcgcttt ctaaagatag acggaaaacc gcctgtcaag 3190081 ctgtcaggcg gctataaaaa gttccaattg aattaagctt ggtttgaaga accaaattca 3190141 cgcattttac cgataactgt ttctttgatc gcttcacgag ctggtccaag gtatttacgt 3190201 ggatcgtact cgtcaggctt agctgccaat gtttcgcgaa cagcttttgc agaagaaatt 3190261 tggttttcag tattcacgtt gattttagct gtaccaagtg aaattgattt tttgatgtca 3190321 gcagtcggaa ttccagtacc gccgtgaaga actagcggaa ggccagttga ttttccgatc 3190381 tcttccattt ctttgaagcc aaggtttggc tcacctttgt aagggccgtg aacagaacct 3190441 aatgcaggtg caaggcagtc gatgccagtg cgctcaacaa gctcttggca ctctttagga 3190501 tcagcgtaga ttacgccttc agcgataacg tcatcttctt gtccgcctac tgttccaagc 3190561 tcagcttcta cagatactcc gtggaaatga gcaagctcaa caactttagc agttgttgct 3190621 acgttttctt caaatggatg gtgagaagcg tcgatcatta cagatgtgaa acctgcatga 3190681 atcgctttcg cacaagattc aaagcttgaa ccgtggtcta agtgaatcgc aacaggaact 3190741 gtcactttgt actcttccat aagtgctttt accatagcaa cgactgtttt gaagccgccc 3190801 atgtagcgtc ccgcaccttc ggaaacacca aggatcactg gagatttttc ttcttcagct 3190861 gcttgtaaaa tcgcttgagt aaactcaagg ttgtttaagt taaattgtcc tacagcgtac 3190921 cctttttctt tagctgtatt caacatttcc gtcatagaaa ctaaaggcat gtcgaatgtc 3190981 ctccttatgt agcctgattg tcttctagcg aaaaaagctt tccaccctag catgacccat 3191041 atattgctgt catatgtaaa tactcagatc gctttttctc cataactagg ataccaactt 3191101 ttcgacaaat cggcaacata atgacatgat tcatttgttt cttctttttg tcagttagac 3191161 ttcaggggca gatatttttt gacggcgtct ctgatttcgt cgatgtcaaa cggcttggca 3191221 aagtgcgtca gagcgcccaa ttccttcgat tcctggatca tgtcgagctc tccgtatgcc 3191281 gtcatgataa tgacccggat gttttcgtca atgaccttca tccgttttaa gatttcgatt 3191341 ccgtccatgc cgggaatttt catgtccaac agcacaaggt cgggccgttc ttttgtcaca 3191401 atgtcaagcg cctgcaggcc gttcgcagcc tgaaacgtct ggtagccttc tttattgaac 3191461 acttcattta gcaaaatacg aatgccgtat tgatcatcaa cgattaaaat tttttcattc 3191521 atcattttac accccaatat tatgattttc gtcaaaagta agcagtattg tatgtattct 3191581 gtttgatttt cctatttcct ttaattataa tagtctactt tacgacattt tctgagcatt 3191641 ttctcttttg ttgtatactg atattgtacg ttataaagga ggattcactt atgttgaaaa 3191701 tattcacgac gcagttaaca ggtatttttt cccgcattca ggataaggaa tctgacgcga 3191761 ttgaagatgg ggcgcggctg cttgctcaag cggtgatcag cgggcattcc atttatttat 3191821 acggagcgaa tgagcttcag ggcgtctttt atgaggccac cgaaagcaaa gaacccttcc 3191881 catctgtcaa agcctttcca gaaaacgctg aggaagtgac agaaagcgac agggtgctga 3191941 tgttttgctc agggacgggc acagccgaag aacaggagct cgcaaaagag ctttatgaaa 3192001 aaggtgcggg agtcgtatgc gtatcgcccg cagccaaaga cagtgcggga atagaacagt 3192061 attgtgatgt gcatattgat tctaaattaa aaatgccgct tgttcccgat gaagacggca 3192121 cccgttacgg gtttccctct ttaatgacag cactgtatgt ctatcacgct ttatcgttta 3192181 cactaaaaga aattctgcaa gagtatgcat aatatcttat tgtacatgct ggaacttgcc 3192241 ggaaacaaat aaaaaagact tgcccgcttt tgacaaacgg caagtctttt ttattacttc 3192301 tgatttgcag cttcgacaga cgctccgata aagcctttga atagaggctg aggtcttgtc 3192361 ggtcttgact tgaactctgg gtggaactga gaagccacga accaagggtg gtctttcagc 3192421 tcgatgattt caacaaggcg tccatcaggg cttgtgcctg agaatacgaa gccttgctct 3192481 tccatttgct gtctgaattc attgttaaac tcatagcggt ggcggtggcg ctcgtacacc 3192541 acttcatcct gatacacttc aaaggctttc gtgccttctt caagcttaca agggtaaagg 3192601 ccgagacgaa gcgttccccc aagatcctca acatcctttt gttcaggaag aagatcaatg 3192661 atcgggtatt gagttgacgg atcaatttcc gctgagtgag cgccttttaa gcccaatacg 3192721 tttcgtgcgt attcaataga cgccacctgc atgcccaagc aaatgcccaa gaacggaatg 3192781 ttgttttcgc gcgcgtattt tgtcgcgacg attttccctt caacaccgcg gtctccgaat 3192841 ccgcccggca caatgatgcc gtctgttccg cttgtgagtt ctgcgatatt gttttctgtc 3192901 acttcttccg cgttgatcca cttcactttt acatctgtgt caaacgcata gcccgcatgg 3192961 cggagagact cgacaacaga aatgtatgcg tcaggaagct caacgtattt gccgacaagg 3193021 ccgattgtaa tcgtttgaga caggttgctg actttgttaa caagctcttt ccactcggac 3193081 atttccgctt ctttgcatgc caatttcatg tgctcgcaaa caagcttatc aagcccttgt 3193141 ttttgaagct ccagcggaat ggagtaaagg ttgtccgcat cttcacattc aataaccgct 3193201 tttgtatcga tgtcgcagaa aagcgcgatt ttatctttca tatcttgaga aatcggcatt 3193261 tctgtacgaa cgacgatgat gtttggctga atgcccaagc tgcgcaattc ttttacgctg 3193321 tgctgtgtcg gttttgtttt taattcgcca gcagctttaa tgtaaggcac gagcgtacag 3193381 tggatgtaca ttacgttttc acggccgatg tcgctcttca tttggcggat cgcttcaagg 3193441 aatggcagtg attcgatgtc tccgacagta ccgccgattt ctgtaatgac aacatctgcg 3193501 tttgtctctt tccctgcgcg gtaaacacgg tctttcaatt cgtttgtgat gtgcggaatg 3193561 acctgtacgg ttcctccaag gtaatctccg cggcgttctt ttttaagaac tgttgaatag 3193621 attttacctg ttgtcacgtt gctgaattta ttcaggttaa tgtcgataaa acgctcatag 3193681 tgaccaaggt ccaagtctgt ttcagcgccg tcatccgtta cgaatacttc accgtgctgg 3193741 tacgggctca ttgttcccgg gtcaacgttg atgtatggat cgaatttttg aatcgtcacg 3193801 ttcagtccgc ggtttttcag caaacgccct aatgaagctg ctacaatacc ctttccaagt 3193861 gaggatacaa ctcccccggt tacaaaaata tatttcgtca tttcgtttgc tcctctcttc 3193921 gctcttagct acatttttaa aatgtactat tttataaaaa atcatttagc cttttaaatg 3193981 atttataaga aaaatgaggg gtgaaaataa gaaagctccc tttcaatttc ttgaaaggga 3194041 gcataacgta ctatgttctc tcttcgtttt tgaagagccc aaaatacata ctacatagtt 3194101 cgactatgaa agtcaagatc gttttgaaga tgaaatctga tactatttaa tttcctcttc 3194161 ttcatcatca tagtcttcat catcttcatc aataatatct tcttcgatct caagatcatc 3194221 gtcgtcttca tcaagatctt cttcgtcaaa atcgtcggct tcaagatcga gttcttcctc 3194281 aacttcatcc aaatcaaggt cgtcttcgtc gatctcttca aactcgtcaa gatcaagatc 3194341 ttcttcgact gctttcttcg cttttttctt tttcgccttg actgtcggct gagtttcttc 3194401 atcaagctga tcataaggat accagctgcg aagcccccac gtctggtcag aaagcgccag 3194461 gaagcggccg tcaatgttta aatctgtata aaattgagca atgcggtctc caagctcttc 3194521 ttttttcacg ccgagcaaag atgcgatttc atttaaaagc tcctgaaaag gaactggttt 3194581 tttatgttct tcaaataatt cgtgagcgat ttcaactaaa gccatttcct ttagctcttc 3194641 ctgtgaatat tgtttgatac ccaaggtcgg acactccctt tctattactt atatgtatct 3194701 gttttatcaa taatgaaagc gattttgtat cgttcttata caaaccatac ctctcattat 3194761 aaacaaaata aaacagaata tgctaccctt aacagcgtta atttaaataa ttttacaaga 3194821 gtgatccgac tgagagatgt tttccgttaa tccgcgagca ttctggagat gaccagtctt 3194881 tgaatttctt gagtgccttc atagatttgc gtgatttttg catcacgcat atagcgttct 3194941 accggataat cttttgtata gccgtagccg ccgaaaatct gcacggcttc ggtcgttacc 3195001 ttcatcgccg tatccccagc catcagtttg gacatggcgg aagcttttcc atatggaagg 3195061 cccgatgatt ctaaccatgc agcctgatag gtcagtagcc ttgaagcttc tatcattgtc 3195121 gccatatccg cgagtttaaa agcgatgccc tgctgctcgg cgatcgattt tccgaattgc 3195181 tttcgctctt ttgcatattg aagcgccgca tcaagcgctc cttgggcgat gcctacagct 3195241 tgtgcagcta tgccgtttct gcctccgtca agcgtcttca tcgcgatttt gaagccttct 3195301 ccttcttctc cgagacgctt tgatgcgggc actacacaat cttcgaacat gatttccgtt 3195361 gtcggtgaag aacggatgcc cagcttcttt tctttcttgc ctgtaaaaaa tccttcaaaa 3195421 tccttttcta ctataaaagc ggtaacgcct tttttctttt tctcgggatc ggtgacggca 3195481 aaaacaatgt aaatatcagc aacgccgccg tttgtgataa acactttgga accatttaac 3195541 acatagtcat cgccgattcg ttcagcagtt gttttcatgc tgccggcgtc agagccagac 3195601 cctgcttcgg tcaaagcgaa tgcgccgatt ttctctccga gagccagctg tgttaagtac 3195661 tctgtcttct gttcctctgt cccaaaggca aacagcggcc agctgcaaag agagatatgg 3195721 gcggaaagcg tcacaccggt ggaggcgcac acttttgaca gctcttccac cgcgatgacg 3195781 taggctaaat agtcacttcc aattccgccg taatcttcag gccatggaat tcccgtcagg 3195841 cccagatttg ccatttcccg aaacagctcg cgatcgaagc gttcttgttc gtcccgttca 3195901 gccgctgtcg gggccacctc atgcttcgca aaatcgcgca ccaattttcg tatcatctca 3195961 tgttcttctg ataatgaaaa attcattgct tctcccccat tttcagatca gcgcctaaaa 3196021 cggattgagc cagaagctcg acgacgtcgt acgttttgac ttggtcttcg gcttccttcg 3196081 cctttgtgcc gtccccaagc atcgtgagac aatacggaca gccagaactg atcaccgatg 3196141 ggttgactgc gagcgcttgc tctgtcctgg cgacgttaat cctgttgcct gtttcttcct 3196201 ccatccacat taatcccccg ccggctccgc agcacatgcc ggtttcccgg cttctctcca 3196261 tttcaacaag ctgcacgccc ggaatggctt tcaaaatctc tctcggcgga tcatagactt 3196321 cattgtaccg gcccaaatag cacgaatcat ggaaggtaat cgtctcatga agcgggtgct 3196381 gcggtcttaa ttttccgttt ttcacaagct cggccagcac ttctgtatga tgataaacct 3196441 cgccttcaaa tccgaaatcc ggatattcgt ttttaaataa attgtatgca tggggatcga 3196501 tcgtaacgat ttttttgaca tcattttttt caaattcaga aatattcttc tcagccagct 3196561 cttggaacaa aaattcattt ccgaggcggc gcggcgtgtc tcctgaattt ttttctttat 3196621 tgccgagaat cgcgaaggac acgcccgcgt gattgagcag cttggcaaag gaaattgcga 3196681 ttttctggct tctgttgtcg taagacccca tggagcctac ccagaaaagg tactcaaatt 3196741 cttttccttc ttttttcatt tcttttacag tcggaatctc agcatccggc gcctcgtcac 3196801 gccaattttc acgttccttg cggttgagtc cccacggatt cccttgccgc tcaatacttg 3196861 tcattgcgcg ctgggcgtca ctgtccattt ttccttctgt cagtacgagg tagcggcgga 3196921 ggtcgatgat tttatccacg tgctcattca tgaccgggca ttgatcctca cagttccggc 3196981 aagtggtgca tgcccaaatt tcttcctctg tgatgacgtc gccgatcaag cttggattgt 3197041 aatcaagcgc cgctgcggct tcctgcgatc cgctgcccgc tgacgccgca gccagctgat 3197101 tgcctctcgt atgccgaaac gctgctgcgg gcacccatgg ggagcgcgag gtgacggcag 3197161 cgcctttttc cgtgagatgg tctctgagac gcaaaatcaa gtccatcgga gaaagcattt 3197221 ttccggtgcc tgttgcagga cacatattgg tacagcggcc gcactcgaca cacgcgtata 3197281 gatcaagcag ctgagactgt ctgaaatcct caatttttcc cgctccgtag ctttctttcg 3197341 tttcgtcggt aaaatcaatt ttttcaagtt ttccggcaga ttccattcga ttgaaaaaga 3197401 cgtttgccgg gccggcgatt aaatgggcat gctttgactg aggcacgtac actaaaaagc 3197461 taagcaagaa taggagatgg atccaccatg cgatatagaa aatcaccgcc gcgcctgttt 3197521 tcccgacacc gctaagcata aacgcaatac ctgaggcaat tggctcgctc caagaaagcc 3197581 catgctcatg ccaaatcaga ttcatcccgt tcccaagcag aacggtcagc attaatcctc 3197641 cgataaaaat gagaacgagt ccggctttga aaccgcgttt cagcctcacg agcttttcga 3197701 tataacgtct gtagaatgcc cacccaacag caattaaaat gagaaacgta acaatttcct 3197761 gaaaaaaggt gaaggcggga tagaccgggc caagcgacag attccggccg ggagccagtc 3197821 ctttgatgat aaagtcaatt gctccgaact gaaccaatat aaatccgtag aaaaacatga 3197881 cgtgaatgat tccgcttttc ttgtccttga gcagtttttt ctgtccgaat acattcaccc 3197941 atatggcgtg aagccgttcc ttgaaccgtt gatcaaattg ttctttctgg ccgagcttga 3198001 tgtaggccag tctcgttttg accaagtaaa caaacaaata gacagcgtaa gcggttacaa 3198061 tcagaaataa taatgcattt gcgatgagaa agccgctcat tccaattccc cctttttact 3198121 gataaagacc gcgatcccct acccccgaat ctgtataaga ttatctttat gataaataat 3198181 gaatgagtgt tcagtcaata attaaattcc tgctgttcgg gcacactacc tttactacgg 3198241 aaaggagtgc cggtatgaag gtatttatcg tgattatgat cattgtcgtt attttctttg 3198301 ccttgattct gcttgatatc ttcatgggcc gtgccggata cagaaaaaag gcgtacgagc 3198361 ctgttttttc aaaaaagaag agtgacatcg aattgatcca ctgcggcgct gatctcgttg 3198421 agcggatgat gaatgatatt cgccaggccg cctcttctgt tcacatgatg ttttttatta 3198481 tgaaaaatga tgaggtcagc cacaatatgt ataccttgct gaaaacaaaa gcccaagctg 3198541 gcgtatccgt ttatttgctt ctggattggg cgggctgccg ggcaattaaa aaaacggcgc 3198601 ttcagacgat gaaaaatgcc ggcgtccatg tccatgtgat gaatcgtccc cgttttcctt 3198661 ttttcttttt tcacatgcaa aaacggaatc accggaagat tacggtgata gacggaaaaa 3198721 tcggttatat cggcgggttt aatatcgccg aagaatatct tggaaagaag gcgaagttcg 3198781 gcaattggga ggattatcat ctgcgcatga tcggagaagg cgtacatgat cttcaaacgc 3198841 tttttgcttc tgatctaaaa cgaaataccg gaatcgaact gggttcggat gtttggccaa 3198901 agcttcagca agggactatt tctcacaaga tctatgcgac cgacggttat tcccttgaaa 3198961 acatatactt ggccaacatt gcccaagcga agaatcgcct tacggtttgc acgccttatt 3199021 acattccatc aaaaccgctt caagaggccc ttattaacgc aagaaaaaac ggcgtatccg 3199081 tgagaatcat tgtaccgatg aaatcagacc atccgctggt acgagaagcg gcttttacgt 3199141 attattcgga gctcttggat gccggctgtc ttatttatcg ttattatcaa gggttttatc 3199201 atgtaaaagc cctcatcata gacgaccatc tcagcattat cggaacagcc aacttcgata 3199261 aacggagcct gttcttaaat gaagaggtga atgttgaaat tgatgacgaa gcgtttacaa 3199321 gtgaagtcta tgccacaatt gaggaggata tgaaaaagtc ggagctgctg acgatggagg 3199381 atttcagcaa gcgcacattc aggcagcgcc cggcggaatg gctcggcagg gcattatctt 3199441 atttcttata aaggagagtt cctatgattt tcagattcgg gttcgtttca aatgcgatga 3199501 gcctttggga tgcgtctccc gctaaaacat tgacattcgc gcgttattca aagctttcaa 3199561 agactgaaag aaaagaagcg cttctgactg tgacaaaagc caatttgcgc aatacgatga 3199621 gaacccttca ctatatcatc ggccacggca ttcctttgta ccgtttttcc agttcgattg 3199681 tgccgctggc tacgcatccc gacgtgatgt gggattttgt aacaccgttt caaaaagagt 3199741 ttcgggagat tggagagctt gttaaaaccc atcaactgcg aacaagcttt catccaaatc 3199801 aattcactct gtttacgagc ccgaaggaat ccgtcacaaa aaatgcggta acagatatgg 3199861 cgtatcacta ccgcatgctt gaggccatgg gcattgctga tcgctccgtt atcaacattc 3199921 atattggcgg cgcttacgga aataaagaca ccgccactgc acaatttcat caaaatataa 3199981 aacagctgcc gcaggagatc aaagagcgga tgacacttga aaatgatgat aaaacatata 3200041 caacggaaga aacgcttcag gtctgtgagc aggaggatgt tccgtttgtc tttgactttc 3200101 atcattttta cgccaatcca gacgatcacg ccgacctgaa tgtagcactg ccccgcatga 3200161 tcaaaacgtg ggagcggatc ggccttcagc caaaggttca cttgtcttcc ccaaaatcgg 3200221 agcaagcgat acgcagccac gccgattatg ttgacgccaa ctttttgctg ccactgttgg 3200281 aacgctttag gcaatgggga actaatattg atttcatgat tgaagcaaag cagaaagaca 3200341 aggcgcttct ccgcttgatg gatgaattaa gctccatccg cggtgtcaaa cgcatcgggg 3200401 gcggtgcgct gcaatggaag tcataaatgt gcaaaaatag gtttacgact tgtcagcttt 3200461 gggaacttag gctatataag acaacaatcg atggaggaga aagatcatga aaaatatcaa 3200521 gtctctgaaa gtagccgcac aggcctttac tttaagaaat ttgattcatc tttataaaat 3200581 gtgccattcc ggaagccacg aggtttatat ttattcaaag aaaacgatgt gcaaaatcaa 3200641 aagcttaatt gagcttgaaa cgttccgcat ggctcataat gaaaaggaat atctgatcgt 3200701 agttgaagga acaaaagcat cacagctcat tgaaaaattc caaaatctca tcgagcctgc 3200761 tgagagagaa gcgctctaac ttacatacaa aaaaggatag acatctgtct atcctttttc 3200821 ttatgctctt acataatgga gctgaaccgc ttgtccaaat tgttttgtcc cttttaaccg 3200881 cagttttgtt tcatttgtta gttcgtgaaa cagcgggatg ccgcttccta aaacgacggg 3200941 aataacagtg atgatgaatt cgtcgatggc atcttctttc ataaagtcat tcacaagctc 3201001 tgccccgcca gctatccaga tgtttgagcc tttttcctgt ttcaaacggg cagtgaaggc 3201061 tctggctccc tcattgataa acgtcacatg ttcatcttga taactgtcgg gcgatcctgt 3201121 aaaaacatag caggttttat cctgatacgg gaaaaccggt gttagcactt taacgtgctc 3201181 atatgtgctc cgccctaaaa tgactgtatc aacagtctga taaaaatcac tgtagccgtt 3201241 gtcaccttca ccttcaaatt catccagcca atcgatgctt ccatcttctt ttgcgatcat 3201301 cccgtccaat gaaacagcaa tgtacagcac agtttttctt tccatgttct cctcctatcg 3201361 atgcaccatt tgcccgaatt gcgcttgatg cagcctgctg tataggcctc cggcttcgat 3201421 caggtcttga tgacggcctt gttcttcaat accgttgttt gtgacgacta caattctgtc 3201481 cgcgtctttg attgttgcca gcctgtgggc gatgacaagc gtcgtgcgcc cctcagacaa 3201541 ctcttgaagc gccttttgga tcgccgcttc cgtctctgta tcaagggctg aggtggcttc 3201601 gtcgagaatc aagatcgacg gatttttcaa gaacatcctt gcaattgaca gacgctgttt 3201661 ttgcccgccg gaaagcttca cgccgcgttc gccaatcata gtatccaacc catcgggcat 3201721 gttatggacg agctcttcca gatgcgcctg cttcacagct tgccaaatgt cttcttctga 3201781 tgcgcctagt cggccgtagg cgatattttc tctaagcgtg cccgagaata agaaaacgtc 3201841 ctgctgcacg acgccaatct gcccgcgcaa cgaagaaagc gtcatgtctt ttatactgat 3201901 gccgtcaatc gtaatgtcgc cctccgatgc ttcataaaaa cgcggaagca gactgcaaag 3201961 cgttgatttc ccagcacctg acggaccgac gaacgccacc gtttcccccg cttgaatgga 3202021 taggttgatg tcattgagga cattgtgatg gtcatcatag ccaaacgaaa catgtttata 3202081 gcggatattg cccttcaggc cggaaacatc tttcgaatca ggtgagtcct gaatatccgg 3202141 ctctgtctcc atgagctcca tatagctttt gaaacccgcg atccccctcg gatacatttc 3202201 gataatggca ttaattttgt caataggcct gaacagcaca ttcgtcaaga gtacaaacgc 3202261 cacaaattcc ccgtacgata aggagccgcg aatgacaaac cacgtcccgc acaaaaggac 3202321 aaacagcgtg acaaaccggg tcagcatata gctgattgaa ccgtttttcg ccatgatttt 3202381 gtaggaagaa agctttgtga cacgaaaacg ctggttgttg acggcgaagc gttctttttc 3202441 aaatgcttca tttccgaacg cctgcacaag ccggatgccg ccgatgttat tttctacacg 3202501 cgcgctgaag tctccgatat ccttgttcag cgtggtaaat gctttggtca tttttttgtt 3202561 gaaataaagc gctagccaaa tgacgatcgg cataatgata aacgttaata aagcaagctg 3202621 ccagttaata aacagcatca ctccgaacgc cccgagaatg gtcatgaccg caatgaataa 3202681 gtcttccggt ccgtgatggg cgacttcacc gatatacatt aaatcgttcg tgagcttcga 3202741 catcagcgtt cccgtcttgt tgttgtcgta aaatttgaac gagagctttt gcaaatggtc 3202801 aaaaagcgac tttctcatat cagtctcaat attgatacca agcatgtgtc cccagtaggt 3202861 cacgatatac tgaagagccg agctgagcgc gtacaccgca aataacccga ttgaggtcgc 3202921 gatgatcagt ccccagtccc tgcccggcag caaggtatca ataaaataat tgacgatcaa 3202981 aggaaaactc agctccatta aacctcccgc gatcgctgag aaaaagtcga gaaagaacaa 3203041 cgttttatat ggtttataat atgaaaaaaa ttgccgcagc accctatctt cccccaatgt 3203101 ataaataact gataatattt ctcaattata ctatacacgg gctgttttgt aagatcagat 3203161 ttcttttttc ttacagaaca cctgaaaaca ggcgggcaaa cgactctttt gtccggtcag 3203221 ccacacctct tttataaaag ccgacagggc tgagcttttc actttcctgc atatcctctt 3203281 caaaatgggc ctcaagggtt cggatcgctt cggcatccgt gaagaacaca ttcacttcaa 3203341 agttgagctg aaagctgcgc atgtccatat tcgcggtacc gacggaggcg agatcgccat 3203401 caatgatcat gactttttga tgcatgaagc ctttttggta ggagtacact tcaatgccct 3203461 caaggagcag ctccgggaaa taggacctcg acgcgtattg ggtcaaaaag ctgtcgttct 3203521 tctccggcac cataaccctt acctctaccc cctttgtcgc cgctgctttt agcgccgtgc 3203581 gaatggattc attggggaca aaatagggcg tggcgatcca tattgatttc tgcgctgaag 3203641 aaatcatttc ataataaagg tcgctcatgc tttccttcat gtcagggcct gtcgcgacaa 3203701 tttgataaat gcctcctcct tccacgggaa ccggggtatt gtactcctct tgatcaatta 3203761 gcacttcatt ggagacatat tcccaatcca gcataaagat agcgtggagc gtttgcacaa 3203821 tttccccctc aagccgcagg tgtgtatctc tccaaaatcc gatgtacgga tctctgctga 3203881 tatattcctt cccgacattt aatccaccca caaaaccggt tttcccatcg atgatcacga 3203941 ttttccggtg atttctgaaa ttcagcttct ggttgaaaaa cccgtatttc agcggagaaa 3204001 acgggacgat gtccaccccc gcttgtttca ttctcataat atctcttctt gccagcttca 3204061 tgcttcctgc cgcatcgtat aaaaacctca cctcgacacc ctggcgcgct ttctccatca 3204121 taatatccat catgccgcgt ccgagcatgt ctgatttaaa catgtagtat tcaatatgta 3204181 tgtaagattc cgcttttctc attgctttga aaatgtccgg gaaggtttct tcgccgtttt 3204241 tcagcacttt gatgttgctt ttcgtattga tattcatatg ggcagccctg atggaatatg 3204301 taaagaacct ctcttgattg tccttcagcc ctgtcacttc gggcgtttcc tccttgtcaa 3204361 acagcttcct gagcttttcc ctgttgtaca ttcgttttgt cttaaacagc tttcccttta 3204421 cataaagctg tcccgaaaac agataaaaca cgtagccgac gattggaaaa aagacaagaa 3204481 tatggatcca tagcagcgtg tgctgcgagg tgcggttttc aagaattaat gaatagatgc 3204541 tgaacaaaat aatgcttata tagcaaagca atcctccgta aaactcaagt ctggaaaccg 3204601 gaaaaaacca aatgacatat gccccgatga gcatcatata taaaaagaaa aattccagtc 3204661 tccttttcag catcctgatt ctctccaatc tgattcaatt acctctgtat tacctctttt 3204721 ttctaatcga taaaccttgt aagtaaaaaa cctctccgcc aaaggaggag aggtttagag 3204781 aaaactaact gtcacggaat tcatccgcat cgtttctgca gaaataaagc aagactattg 3204841 gcaacgccga gtgacaacat gagcggcaag ctgaacccgc tcagcactcc ggcaagcgcc 3204901 gaaaagaagg cggcgctgtg actgcaaata cggtggatag agtaaatttg atacccattc 3204961 tgatgagaga aaatatataa aacgggaaat tgatcagaaa gatataagga gttagtcagg 3205021 ctgaatcata atctggctgt tccgccggtt taaaatgagt aaaatccttg atgttatttc 3205081 catatacaaa cataacagga ttcccggcag cccagccatt accttggcag aaaaaacccc 3205141 ctcttgcaag ggggattttc acgagcgttt ccgatataca acgtagctgc gggtcagata 3205201 cttgagcggc agactgaaca catgaaccaa tctcgtaaac ggccacagga taaaaacgac 3205261 gtatcctatc acaatatgaa acttaaacca tagcgggaca ctctccatca aagaggcgtc 3205321 aggcctgaac aaaacgattt ccctgaacca gggcccgact gtggtccggt aatcaaatcc 3205381 tttcgaatca atgttgagaa acgtggccgc aacgcctgac agcatcatga acagcagcag 3205441 gaggagcgta aggatatcgg atggcgagct cgttttgcgg attcttttgt caaacagcct 3205501 tctgtacgtc aggatgacaa gtccggtaca tgccgcaatg cccgccggca agccagcgcc 3205561 aatcgccatt ttgtgataca tatgctctga aatgccaagg gaagcataca cgccttctgg 3205621 gatcagaatc cccatgacat gcccgccgac aacgcacagc agtccccagt gaaaaagtgt 3205681 gctgccagcc gcaagttttt tcttttctaa cagctcgctt gatttcgccg tccagccaaa 3205741 ttggtcatgc tgatagcggt aaatatggcc gccgataaag attgtcaata caatgtatgg 3205801 cataataccc cagaggatct gcccgctcat gcctgaacag ccccttcaac gctttcacgt 3205861 acgccaatgt tttcaagcgc ggccagcagc acgtgcagca gttcagcgta tatactgtca 3205921 tttttttcga gacgggatgc cagctccctc acattggaca gatatttctc aaacacgctt 3205981 ctcgctgctt caatttctgc agccgcagca aattccagca tcagcggcag ataatcaggc 3206041 agctctttct ctgtcggcag gaaaccggat tgctcgtatg tgttttttaa atgcagcaat 3206101 tcaatgccgc gttccctttg ctcgcctgag ttaaagtagg tgacatacat atttgttttt 3206161 ttcccgaagt cgaatgtata gacatagtgt tcaatcagcg cttccggaga atagctggct 3206221 gacgtctcga aaaagtgcag cagcttctcc cggatttgcc ggttgccgat ttcttggata 3206281 agagccttcc aatcgggaag ctcggctctc cactcttcat ccggataaga gagaagacag 3206341 gaaagagcag agaacgtgat ttgccggtct gtggtgttca tcttgttaca cctcatttat 3206401 caaaagttag aaacaggagc cggggccgcc tgaaaatgat aagccgcagc ttccttgttc 3206461 agcgtataaa tctgatactt cttctcgatg gctgctcgga atcacaaagc ggtcatcata 3206521 tttggcaatc gcaagcagcc gatacatatc ttcaatttgc tgttctgtta agccgacact 3206581 ggagatcagt tccggatcga ttgatttatt cgtctggacc gctctcatat actggcgcat 3206641 gacagacatt ttctttaatg ttgaccgaat atgatccgta tcaccggctg ttaacagctg 3206701 cgccaaataa tctatcggga ttctcatttg gtcgatagcc ggaaaaatat cttccgccgt 3206761 ttgccggctg ccttttcctt caaagagatt cataatcggg ctgagcggcg gaatgtacca 3206821 caccattggc agcgtgcggt actcaggatg aagcggcagc gcgatcttcc agtcaatgat 3206881 cattttatag atcggtgatt gctgcgcggc ctctatccat tcagccggaa tgccttgttc 3206941 ttttgccagt ttggcaacct caggatcatt cggatcaaga aaaacgtcca attgggaatg 3207001 gtagagatcc ttttcatttt caacagatgc cgcttcctcc actttgtccg cgtcatatag 3207061 catgacgccg aggtagcgga ttctgccaac acacgtctca gagcagatgg ttggcagtcc 3207121 cgcctccaaa cgcggaaagc agagtgtgca tttttccgct ttgttcgttt gccagttaaa 3207181 atagactttt ttataaggac aggatgagac gcaatatctc catgaacggc atgcgttttg 3207241 atccacaagc acaatgccgt cctcctcgcg tttgtacatg gcgccggatg gacaggatga 3207301 gacgcatgcc gggttgatgc agtgctcgca aatacggggc aaatacatca taaagacgtc 3207361 atcgaattct gttttgatcg attcctccat cttttgtacg ttgggatctt caagtcccgt 3207421 aatgtggccg cctgcgagat cgtcctccca gttcggtccc cattcgatat tcatgaaatc 3207481 ccccgtcaag gacgatttcg ggcgtgctac cggctggtgt tttttctgcg ggctgttcgt 3207541 taatgtttca taatcatagt tccaaggttc atagtaatca tcaattgacg gctgattcgg 3207601 attatagaaa aggcctgcaa gccgattggt tttcgagccc gatttcagct cgagctttcc 3207661 ttttttcaat gtccagccgc ctttatattt gtcctggtcc tcccattgct tcgggtagcc 3207721 gatgcccggc tttgtttcta cattattgaa gtacatatat tccgcaccgg aacggtttgt 3207781 ccacgtgttt ttgcaggtga cgctgcacgt gtggcagccg atgcatttat ccaagttcat 3207841 gaccataccg atttgcgctt taatcttcaa gccaatcgac ctccttcagc ttgcggatga 3207901 cgacgttcag gtcgcgctga ttccccgttg gaccgtaata attaaagccg tagctgagct 3207961 gggcgtagcc accgatcatc tgtgtcggct tgacgtgaat ccttgtcggg ctgttatggg 3208021 tgcctccgcg gttattcgtc agctttgtgc cgggcacgtt gatgtggcgg tcctgggcat 3208081 ggtgcataaa cgccattcct ttaggaatcc gatgagacaa aacggctctc gcgacgacaa 3208141 cgccgtttcg gttgaagcat tcaatccaat cgttgtcttt gatatccgtg tcctctgcat 3208201 catctttatt catccacacg gtcggcccgc cgcggaacag cgtcagcatc ggcagagaat 3208261 caaaatacat gctgtggaca gaccatttat tatgcggcgt caaataattg aggacgattt 3208321 cttttccctc ttgatcaggc cgtttgctca gaaacgggcg atgctggagg atcggtttga 3208381 atgtcgccat cgtttcaccg aattccatca tcagttcatg atcgacataa taggattgtc 3208441 tgcctgtcag cgtccgccac ggaattaatt tttcaacatt cgttgtaaac ggcgaatacc 3208501 tgcgccctcc tttttcagag ccggtaaacg ctggagacgt gatcaccgtt ttcggctggg 3208561 ctgtaatttg ttcgaacgta aagcattctt cctcgcgttc ttccgccagg tctttcagct 3208621 tcaggttcgt gatgttttca agtgattccc atgcttttac tgcgaccttt ccattcgaag 3208681 tggatgatag ggttaaaatc gcttctgcag cctgctttgc ttcacttata tttggacatc 3208741 cctttgccac gctgtccgag gtgatttctc ccagtctctg tttgagtgat tcatattcat 3208801 cggctattga ccagctcatc ccttttgttc cgctcggctt taaagcaacg ttcggaccaa 3208861 gtgcagtcat tttatgaaaa atgtgtttgt aatcccgttc aacgacttgg atgttcggca 3208921 tcgtttttcc cggaatggct tcacattcgc ctttgctcca gtcattgatt ttgccgaatg 3208981 gctgggccaa ttcctgcatg gtgtcgtgga gcagcggtgt cgcaaccact tctttcaccg 3209041 gctccatatc gacttcttct gccagatcgg aaacggcttt tgacagcgcc ttgaaaatat 3209101 cccagtctga cttcgattcc cacggagccg agatcgcagg agcaaatgga tgaatgaacg 3209161 gatgcatatc tgtgctgctg agatcgtgtt tttcatacca tgtcgccgcc ggcagcacga 3209221 tatcggaata cagcgccgta cccgccattc gaaaatcaag attgattaat aagtcgagct 3209281 ttccttccgg cgcctgctcc cgccatttga tttcttctgg gcggatgctg tcgctgtcgt 3209341 cattcattaa accgttcgtt gtccccagca aatgcttgag aaaatattca tgcccttttc 3209401 ctgagcttga gatcagattt gcccgccata caaagagatt ccttgggaaa ttcacttcat 3209461 tgtcaggatc ttcaatcgcg aatttcagtt ttttctcttg gagctgtgag gccacgtacg 3209521 cacctacgtc ttcaggtgtt gctgcccctg ctttttcagc ttctttatac agatcgatgc 3209581 cattttgatt gaaagtcggg taagacggaa gccaccctag ccgcgccgcc agcacattgt 3209641 aatcagcgtg gtgcttgtag cgggatgaag cagcaatcgg tgatgccaaa tcactgatcg 3209701 gctggtcctc ataacgccac tgatctgtcg caaagtagaa aaatgaggtg ccattttgca 3209761 gcttgggcac gccttcccag tcctttgcag ttgcaatcgt ctgccaccct tcagcaggtc 3209821 ggagcttttc ctgccccacg taatgggccc agcctccgcc gtttacgcct tgggcgccta 3209881 caagtaaaac aagatttaac actgctcggt agatcgtgtc ggagttgaac cagtggttaa 3209941 tgccggcccc tacgataatc atggaccggc cgtctgtatc gatcgcattt tgggcaaact 3210001 ctctggcaat cttaacgaca gcttcttttt tgattcctgt catttgttcc tgccaggcag 3210061 gcgtaaacgg ctcagggtca tcataggaga cagccgatcg ttcgccgatg ccccggttca 3210121 cgccgtagtt agccagtatc aagtcaaaca cggtcgtgat gtacgtttct tcaccgttca 3210181 ggttcatttt tttaatagga agatcccgct cgagcacttt gtttccgtca tttgaaaaat 3210241 acgggatgcg caccgtgccg atttcgtcct ctattcccag cacagagaga cggggttcaa 3210301 tcggttcccc ggtttcttca tcaatcatgt gcaggttcca tttctgctgc ccgtcccagc 3210361 gcgagcccat tgtcccttgg ggtatggcaa atgaacttgt ctgttcatcc caaaccgcag 3210421 gcttccactg atcatgcttt gtcttccgcc cgatgtcctt cgcatgcaga aaccgtcccg 3210481 ctgtgtatac gccattttct tttgacagag tgacgagaaa tggaaaatca gtgtattgct 3210541 tcgcgtactc aataaaacgt tcagtttctt ggttcacgta aaattcctgc agaataacgt 3210601 gacccatcgc catcgcaagc gccccgtcag tcccttggcg aatactcagc cagtcatccg 3210661 cgaactttga ggattccgca aaatctggac tgatcgaaat gaccttagcg cctttatagc 3210721 gggcctccgc caaaaaatgc gcgtcaggcg ttctcgttaa cggaacgttg gagccccatg 3210781 tgataatata gccggaattg taccaatcac tgctttccgg aacgtccgtc tggtcacccc 3210841 aaatttgcgg ggatgctgga ggaagatccg cataccagtc ataaaaactg agcatagggc 3210901 ctccgattaa cgacataaac cgggagcctg atgcgtggct gatcatggac atggccggaa 3210961 tcggagaaaa accgacgttt cggtcaggcc cgtatttcat cactgtatac agcagagagg 3211021 ctgaaatcag cttcagcacc tccggccatt cagcgcgcac aaaaccgcct ttccctctcg 3211081 cctgtttata ggacttcgct ttttcagggt tttcgacgat cgatttccag gcttccaatg 3211141 gattttgatg cgtctgcaat gcctcccgcc acaaattgat cagcacaccg cgcacgtatg 3211201 gatatttcac acggagcggg ctgtagatat accatgaaaa actggccccc cgcgggcagc 3211261 ctctcggttc aaaatcaggc atatccgggc ctgttgatgg ataattcaaa ttttgccctt 3211321 cccacgtgac tattccgttt ttcacataaa tattccagct gcaagaccct gtacagttga 3211381 cgccgtgggt ggagcgaacg actttgtcgt actgccatct gtttctgtat acattctccc 3211441 aatcgcgatc ctcgcgggta gtttggctat gtttatttga atggtgttcg ataggagaga 3211501 aataattcaa tctcctaaac aacggactcc ttttcttttt cttcatgaga gttcactcct 3211561 tccgagtcag gtgatgctaa gttcactata aacagagaca gcgtgtttcc ttgtgaacta 3211621 tgtcacacac tctgcttttt tcacaaaatg ttcacacaaa ggagaaggaa ggctgcgttc 3211681 aggcaggacg cttgggtcat tagctgcctt tcattcaaag atcaaaaaaa accggctcta 3211741 tttaagaacc gggctcagcg ttttcatcct gtgatgtatg cagataccgc aaaaataatt 3211801 gataggaaca aaaaacattt tgctgaagca tagccaaaaa gttcatttgc agctgcggat 3211861 gataagacat cattttctta aatatgtaat atgggatgtt gagaatcaga atgtctgaag 3211921 tggcattgac tgagataaag ggcgataaat aaagcccgcc tttttcatca atcggaaaca 3211981 catcgccttt ttcccacagc gcaacggttt tcgacccttc agggagcctt gtgtccataa 3212041 aacggacact gccttttaat acaatataaa cagattgaga atgaagaaaa gatggagact 3212101 gatcacatga accgcggata aacgtgccgt ttttcagcaa ggtttcgaca atggatagag 3212161 gcacttcatt aaacatagga agttgtttca gaaataataa atagtcacac tgattcatag 3212221 gaaaacctcc tgtgctaagg atagctttag tgtagctcga ctgagcctgt acagcagtga 3212281 tgtatttcac agcctgtatg atgaatgtca cttatcagga gggtgaatgc atttataatg 3212341 aaagaaaaaa ggaggatttc gatgaaggcg ctgattccga agcagcacgg ggcgtgggcg 3212401 atgctgctga tcccattttt actcggcatg gtcaagggag gccccgttat ttggcatatt 3212461 ccgctcttcc ttggttggct tttcctatac ttagcggttt atcccgttac gcttgcctta 3212521 aaaaagaaac aaagcaaacc atatcaaaag tggatgtgtt attacggttt tcccacctgc 3212581 tgctttttga tgatctcggt ctttcataag ccgcctctca tctgggtggg cgtttcttta 3212641 ctgccgctgt ttctcataca tatgtatttt gcccgcagaa aaaacgaacg agccttattg 3212701 aatgatgttg caggtgtctt gttcttttgt tcgggcgggt ttgcgagctg ctggctgggg 3212761 atgggaaccc ttgacggctg ggcttggttt attttcttgc agtctgcttt attttttatc 3212821 gggagttcct tttatgtgaa atcggtgatc cgcgagagaa aaaacagggc atttgcatac 3212881 tggtcatggg gatatcacct gctgctcccc tttttatccg ctcttttcgg agcaggatgg 3212941 gcgtttctcg cttttatccc gagcagcttg cgggcatggt tttttcatgg aagggattgg 3213001 cccgtaaaaa cgattggcat tctggaaatc gtgaatgcct gcttctttct tgccgtcatg 3213061 tgcctgttta tcacaaggta aaaaaacaag gacaccgctg tccttgtttt tttcagtcaa 3213121 tattgcaaat ctccagcggg caattttcac actcaatctc acatcgtaaa tagtcccgct 3213181 tgtgcaaaat aatttttccg gattcgtcta tcgaaataac cccttttttg cggagatctc 3213241 cgagcatacg attgacgctt tcccgtgcag ccgcgcaaaa ctttgccaaa tcctgatttg 3213301 tcaggacaat gttaatcaga atgccgtcgc ttcgctccac tccgtagctg tttgataagc 3213361 ggataagggt agaatagagc gccccctttt tgccatgaag aagcagatcc ctgattttgg 3213421 actgaatctt ccggaggtgc gtgctcatcc atttcatgaa ctcaaatgtc aaagcgccgt 3213481 tttggattaa ttctttttcc agcttatttt tattaatgac gagcacctcg ccatcctcta 3213541 gtacttttgc actgagcata taccttggtt cttcagtgaa aagtgttaat tctccgacga 3213601 tatcatgctt ttggcagatt ctaagcgtca ggtcttttcc gtcagatgtc agcttgccga 3213661 tttcaatgag tcctgattga atcagataaa gctcttctgc atccattcct tcccgaaaca 3213721 aatacgtgtg tttttccatt tttcttttcg tgctgatcga ttccagcaat tcatacagat 3213781 cgctggatat aagatcacta tcagatggtc gaacagagag aaaattcatg agctcacctc 3213841 gaagaaagtc acgttgtgtg tttattgtaa cgtgaattga tttgtaccca tcgagaaaaa 3213901 actaacaatc ttgtgaatgc cccagtgtta gttgatgctc tggctgtttc tctccgtgtg 3213961 tgttttcatt ctttcctgcc aatacatcca tatgacaagg acaaaactgg ctaacgccac 3214021 ctctgaaagc gccataaacc cgatcgcgta ctggcctgtt gcctgaaata cactcgccaa 3214081 tatgagcgga ggaaaaaagc cgcctaaacc gcccatggca gacacaatcc cattggcaat 3214141 ccccgcttgc ttcgaaaaat agaaaggcac cagtttaaaa acagttccgt ttcctatgcc 3214201 tgagcagacg gccacggtta atgatccaaa cgtataaagg ccgattgtcg gcgagaacga 3214261 taggataatg cctgataatg taagcccggc aaaaacaaac atcaagatgc ggagcgggct 3214321 cattttatca gccaggaatc cgcccgcagg cctgagcagc gtagaaaccg caataaagcc 3214381 agccgtccgc aagccggcat ctgcaggatt cagcccaaaa tgctccacca gaaagttcgg 3214441 cagatagata gtgaaggcga caaaggcacc gaacgtaata aaataaaaca ggctcagaaa 3214501 ccatagcaca tgatttcggt aaacagcttt gatttgagtc ttaacagaaa ctttgacctt 3214561 cttctcatgc ctgtcgccaa acaatacgtg cagtaaggca aagacagcca gcaaaatcag 3214621 atacatttgc acggttgatt tccacccgac ggcttgagcg ataaccggcg ctgcaaatgt 3214681 cgtaacggct gtcccgatat ttcctgcacc gtaaatccca ttgacgacac cgtgcttttc 3214741 tttcggataa tatttcggga gggaggtcac cccaatggaa aacaccgctc ccccgatccc 3214801 taagaaaaag ccgcctgcga ttaaatcaaa cagagaatcc gcgatactga tccaaaatac 3214861 aggaaataaa agcaggatga agctgaccat aaacatgagc cgcgcgccaa acctgttcgt 3214921 taaataccct aaaggaatgc ggagaagcga cccgaggatc acaggaatcg cggtcactaa 3214981 agaaatctca cccttgctta aatgaatatc taatgtgatt tgggaaatga gtgatgaaat 3215041 cagcacccaa accataaacc ctgccaccaa gcttaatgac tgtaacgata attgaatgtg 3215101 ttgacggttg atcatttggc ttgccccttt caatgattca ataatcagtc ttatcataca 3215161 aaaactagcc aaacaggatt gtgaattaca tcacacgttt ttctcataaa aaaaggacaa 3215221 agcccgaaga ctttgtcctt ttgatcgtga ttacattttt tccggagccg atacgccgat 3215281 cagctgaagc gcattgttca gcgtaatttg cgttgccttc attaaagcca ggcgcgcgcg 3215341 gcttttctct tcattttcag ggtcgatgac tttctctgcg ttgtagaagc tgtgcagagc 3215401 agaagccaga tcataaatat agttagtgac acggtgcgga attcgttttt ccgctgcttc 3215461 cgccactgcc tctgggaagc cgccgatcgt tttcagcaga tcgtattctt tttctgattg 3215521 aatatggctg aaatcaagat ctgccgccgg tttaagcccc tgctcttccc cttggcgaag 3215581 catgctgcaa atacgggcat gcgcgtattg tgcataatac acagggtttt cgttagatgt 3215641 tgatacagca agatctaagt caaaatccat atgggtgtct gcacttcgca ttgcaaagaa 3215701 gtaacgcacg gcatccaagc cgacttcttc aatcaggtca cgcatcgtta cggctttacc 3215761 ggtccgtttg ctcattttca ttttctcgcc gtttttgtaa aggtgaacga gctgaatgat 3215821 ttctacttca agcgttcctt tttcatagcc cagcgcttcg attgccgctt tcatacgcgg 3215881 gatgtagccg tggtgatcgg cgccccaaac gttgatcagc ttatcaaagc cgcggtcaag 3215941 cttgtcctta tgatacgcga tatcaggaag aaggtacgtg tacgtgccgt ccttcttgat 3216001 caatacgcgg tctttatcat cgccgaaagt cgtggaacgg aaccaagtcg cgccgtcttc 3216061 ttcatagacg tggccttttt cgcggagcgc ttcaagcgcc ttgtcgattt ttccattttg 3216121 gtacagtgaa gtttctgaat accacacatc aaacggcaca cggaagtttt ccaagtcctt 3216181 gcgaagcttt tccagctcgt atttcaggcc gtattcacgg aaaaacgcga ggcgttcact 3216241 ttcctcttcg ttaacgaaac gatcaccgta ttcctcagcg agacgctttc cgatcgcaat 3216301 gatatcctca ccgcggtagc catcctccgg catcggtttt tccaatccga gtgcttcaaa 3216361 gtaacggact tcaacagaaa gcgccagatt gttgatttgg tttcccgcat cgttaatgta 3216421 gtattcgcgg cttacatcgt aacccgcttt tgaaagcacg ttgcacaagg aatcgccgac 3216481 agccgccccg cgcgcatgcc cgaggtgaag gtctcccgtc ggattcgctg atacgaattc 3216541 tacctgaact cgttcaccgt ttccgatgtt cgtttccccg tatgcttccc ctgcttccag 3216601 tacagacgga atcagctttg ttaaatattg attgttcata tagaaattga taaaacccgg 3216661 gccggcgata tccagttttt caatcgaagc cttcccttta tcaaaatggg cgacaatctc 3216721 ttcagcgatt tgacgcggcg ctttttttgc cactcttgcc aactgcatcg ccatattcgt 3216781 tgagtagtcg ccgtgtgttt tatctttcgg tgtttctaaa acaacattgg gaatctggct 3216841 ttcttcagcc agtcccgctt tcagaacggc cgctttgatt tcttctttca gcacgtcctt 3216901 catttgttcc gcaatgttca tgcgtgagtt cctccctcat acgtgatcgt catattatgt 3216961 aaatgctcct gctcgtctcc gacatgcatg tcatatgcga tgctgatacg gcctttttct 3217021 tcatcgagat cagattgaat cgattttgtg cttgttttca gctcaagctc accaaatgac 3217081 attttatatt tagcaattgt ggaagctccc gttacgaaac gctgattcat tttgacagcg 3217141 cctgacctca tgaccaggac ttcgccttcg cttactttca caatcgtttt gactttgcct 3217201 aagtcgtgtt cttcataata agatagatac actttatttt gttttacata gtaaaatccg 3217261 gtggtgcgga attcgatgac ttcttggttt ccgtcatcct cgatcacaga cttcacatgg 3217321 agtgttatcg gtgtctcttg cttcattctg acacgtcctt ttcatcattc cactttgact 3217381 tgaatagtat aatcattcgg tttgtaaact tcaactgctt ctatcttacc atcattgctc 3217441 atcagatttg aagataaacc tcataaaaag catttcctta tatagaagag aaaatcatat 3217501 cactaattac ctttaggaaa tgttacgagc tcgctacatc gcaatcgcag acggacccgc 3217561 gccaaccgga atcaccgtca cggctgtata atcacttgtg cggtacacgg tcacagcatt 3217621 gtcgttgggc tgtgccgcat aaatatactg tttgtccggc gttacggcga ggtcaaaggc 3217681 gccggggaga gacacgtttg caatgatcct ctgtctggcc gtattaacta cgtataagtt 3217741 attaatgaga aacggttcac tatatggctc tagaaaataa gctctagtac tatcgagaga 3217801 aaatacaatc gtcctcagcg tttcaaataa acggctgaag tcccctcccc tgcttaatgg 3217861 tgacaaacta atctccgtta cacctttcgg ccacagctca ccattcaata cgtacgcaaa 3217921 atttccagcg taaggagttg taattaaact gggaaattca aatgtatcta tgatactttc 3217981 taccaactgc ccagtattta catcatattt atcaaccgac caactgcttc cattagcggt 3218041 atagacatac tgtccattcg gatcaagagc aaagtctaaa gcgccgggta tcggaatgac 3218101 atcaatgacc gattgagagg ccgtgttaat cacatatata gatccggcgg ccatcacgta 3218161 tgcgaactca tctgttggat caaattcgat ttttctcggc cctcctccaa cagtaatggt 3218221 atttatgatg gttaatgttt tattatcaat cactgagaca aggttggtat ttccatggag 3218281 gacatacgtg aatgctttat cgaaagtaac gcctagatta gttggcacgt cagaaaaagg 3218341 gattgttttt acaacagtgt ttaaatctgc atcaataacc gaaaccgtgc tgtctccagt 3218401 attggcagta aacacatacg attgagggtc tggtgatggc ggtaaaacaa gtgtcccggc 3218461 caccgtaagc ggactgccgt agaaaggcgg tacaatgagc agatcttcca ctgttatttg 3218521 actgaaatca ggacagcggc cagactgtgc tgcataataa acaacttgat caatctcttc 3218581 agtatgaatc acagaaacag ccccgtctcc ttgtccatat tgatttcgta caggcgacac 3218641 actgacaaga agcgtaatgg tcccttgtac tctcacagca tatcgaacac cgatatcttc 3218701 tggttccggc ccagtctgga ttaagcaagg ctcactgata caggacaaat tgtctgtact 3218761 ccatgtaaca gccgctgacg cttcggccgt atcaaccttg aagccctcag ggaaatctat 3218821 cggcacttga aacggcgctt cccggctaat ttcctcatca caaaaacaga aacaattttc 3218881 ctgtaaagca gaaagatcat tctttttcat gatttcacgt ccttttagaa atgcacaaca 3218941 tgcagcggtt aaatcgtaat ggcacccggt gaaaccccaa gagatatcac agtttcctca 3219001 gaataatcat ctgtgttgta aacaatgatg ctctgctcta taaaacgagt tgcatacaga 3219061 aaatcgccat tcggggtaaa cgcatagtct gttgctgatt gcggaacatt tcctataacg 3219121 cctgctccat ttggactgac agaatataaa ttgccagtga agccgtcata taaatacacc 3219181 tctgctccac tcgtaaacat tcgatattcc ccttcatact ccagctcttg ggtgctgctg 3219241 atggtaaacg tatttaaatc aataaccgtc aaataattaa aaaagaattc ttgttctaat 3219301 acataggcat accgctccgg ccaatttgtt tctatggttg atacgataag ctctcgttca 3219361 attgttcctg tgacttcacc ggtagttagg tccacttttt gcactattcc aaaattcaga 3219421 acataggcga ataacccatt gggatcgatt gcaacatcat atccttccac aggaatcgac 3219481 ctatccacag ttaacgtatc aattccaatc acataaaccg cagtaccggt gaaaacataa 3219541 gcaaactcat gattagggat aaatctaatc aatcgaggcg gctgatccag caatatagtt 3219601 gctgtcactg ttaatgtgtc ataatcgatg acagaaatca cattattgtt gggatgtaag 3219661 acaaacacag cgcttttatc tggcgtaatt tcaatacctg ccggattgta cggaagagca 3219721 atcgttgtca caacagtatc ggtgtttgta tcaatcacag aaactgattg atcatttgga 3219781 ttcgctgtaa acgcgtagac gggttccggc tccggtacaa gcacaattgt ccccgtcacc 3219841 gataaaggac tgccgtaaaa cggcggaaca acaacaaggt tctcaatcgt gatgtcactg 3219901 atatccgggc aatcatccga ttcatcggaa taatagacga cttgatcgat ttctgcattg 3219961 tgaatgacgg aaacagcccc gtccccttgt ccatattgat ttcggacagg tgagacactg 3220021 acgagtagcg taacggttcc ctgcaggcgc actgcaaatt gaacaccgac ctcatcaggc 3220081 tcaggccccg tttgaattaa gcaacggtca ctgacacaag aaaggctgtc tgcattccac 3220141 gtcacgtttg caacagcttc agccggatca acgacaaacc cttcaggtaa ttcaatcggt 3220201 gcttgaaaca tggcttctcg gcttgcttct ccctcacaaa aacataagca ctcttcttgt 3220261 tctgctcctg ctttttcttt aaaggaaagc ttgttttttc tcattccttc acttcctttt 3220321 cagacataca ctgctcacgc agatataaca gaatatggaa gggtaacgtg tttgcttgta 3220381 caaattgctg agggtaaacg cttctttttg aaaatatatc tccaaacatg cggtgtaacg 3220441 aaagaaaaaa ttgcggtttt tttgcgcttc tcacaagaat gttgatgata aaatatgaca 3220501 tatatagaat tatgaaggga gggatttgca aacgtgacag gtgtcatatc ttcttcttcc 3220561 atcggagaaa agattaacga atggtatatg tacatacgcc gattcagcat acccgatgca 3220621 gaatatttgc gacgagaaat caagcaagag ctggatcaaa tggaagaaga tcaagacctt 3220681 catttgtact attcactgat ggagtttcgg cacaacctaa tgcttgagta ccttgaaccg 3220741 ttagaaaaaa tgaggattga ggaacagccg agactgtctg atctgctgct tgagattgat 3220801 aaaaaacagg ctcgtttaac tggtctgctt gagtactatt ttaacttctt cagaggcatg 3220861 tacgagctgg accagcggga atatctgtcg gctattaaat ttttcaaaaa ggccgaaagc 3220921 aagctgatat tcgttaagga tcggatagag aaagctgagt ttttctttaa gatgtctgaa 3220981 tcttattact atatgaaaca aacgtatttt tcaatggact atgcacggca agcatatgaa 3221041 atatacaaag aacatgaagc ttataatata agattgctgc agtgtcattc tttatttgcc 3221101 accaattttt tagatttaaa acagtatgag gatgccatct cacattttca aaaagcttat 3221161 tctatggcag aagctgaaaa gcagccccaa ttaatgggga gaactttgta caatatcggg 3221221 ctttgtaaaa acagccaaag ccaatatgag gatgccatac cttatttcaa aagagcaata 3221281 gctgtttttg aagaatcaaa tattcttcct tccttacctc aagcgtattt tttaattaca 3221341 cagatccatt ataaattagg aaaaatagat aaagctcatg aatatcatag taagggaatg 3221401 gcttattcac aaaaggccgg agatgtaata tatttatcag agtttgaatt tttgaaatct 3221461 ttatacttat caggcccgga tgaagaagca attcaaggat tttttgattt tctcgaaagt 3221521 aaaatgttgt atgctgatct tgaagatttc gctattgatg tggcaaaata ttatcatgaa 3221581 cgtaaaaatt ttcaaaaagc ttctgcttat tttttgaagg tggaacaagt aaggcaactt 3221641 attcaaggag gagtgagttt gtatgaaatt gaagtctaaa ctattactct cttgtctggc 3221701 tctaagcact gtgttcgtgg caacaactat tgcaaatgca cctacacacc aaattgaagt 3221761 tgcacaacga ggaatgattt aaccgccgtc catcggcggt tttttcgtcc cctctttacc 3221821 aaagtctccc aatccatgct atgatctttt caataatctt gaagagagtg gaaatgcagc 3221881 atgtctctaa aaagtgtgag aacccacttt actcaatgga atcgagaaaa tgatgtgacg 3221941 gagttcgaaa cgtcgagtgc gacagttgaa caggcagctg agacaatcgg cgtaagcctg 3222001 tctagaatcg ccaagtccct gtccttcaga ggggaaggag atcaggtgat tctgattgtg 3222061 gcagccggcg atgccaagat cgacaacaaa aagtccaggc aaacatttgg ctttaaagca 3222121 agaatgctct ctcctaatga ggtgctggag cagacaggcc atgaaattgg aggagtttgc 3222181 ccatttggat tggctcatga tcctgaggtt tatcttgatg tatcgctgaa acggtttcag 3222241 actgttttcc ccgcatgcgg cagcagaaac tccgctattg aattaacacc gaaagaatta 3222301 tccgaatttt ctttctcaaa agtgtggatt gatgtttgta aagactggga ataaaaaaac 3222361 atccagacat cgtctggatg tttacttatt tcacaaaccc aagcagcatt tcacggatga 3222421 ttttgctggc tgtgtttgcc gtttgctctg agtggtcgta taccggcgcg acttccacta 3222481 aatcagcgcc ctttacgttt acctctgaac gcgcaatttc atggaccgat gcaagcagtt 3222541 ctttagacgt gatgccgccg gcgtcaaccg ttcctgtacc cggtgcgtgt gcagggtcta 3222601 atacgtcaat gtcaattgtg acataaaccg gacggcccgc cagcttcgga agcacctctt 3222661 tcagcggttc aagcacttca aattttgaga tgtgcatgcc gttttccttc gcccattcaa 3222721 actcttcttt catgccggaa cggattccga atgaatacac attgtgcggt ccgatcaatt 3222781 ctgccgcctt acggatcggc gtggagtgag aaagcggttc tccctcataa tcaacacgaa 3222841 gatctgtatg tgcgtcaaaa tggataatcg caaggtctgg gtatttcttg tacatcgctt 3222901 taatgacagg ccatgacacg aggtgctccc cgcccatacc cattgggaac ttcccttttt 3222961 ctaaaatgct gtccacgtac tcttcaatca tatccaggct tcgctgcgga tttccgaacg 3223021 gcagcggaat gtcgccagcg tcaaagaagt tcaagtcagc cagatcgcgg tctaaatatg 3223081 ggctgtattc ctcaaggccg attgacacct cacggattct gcttggacca aagcgtgagc 3223141 ccgggcgata gctgactgtc cagtccatcg gcatgccgta aagaatggcg tccgcctctt 3223201 cccactcggg acggctcgcg ataaatactt ttcctgaata agcttcatca aatctcatct 3223261 ataataccct cgctttcctg taaaaaagcg caagattcgc tcctgcgcca taccttcatt 3223321 atttaatcag gtcactcaca aatttcggca gaacaaacgc cgctttatga atatcttttg 3223381 tgtaatattt cgtctcaata tcgaagaaac ggctgtcttc cactgcaagc ggatcatatt 3223441 ttttcgagcc aattgtaaat gtccacaaac cgcttggata tgtcggaatg ttcgccgtat 3223501 acagcttcgt aatcgggaag atttccttca cgtcgcgctg tacatttgtg attaattccg 3223561 gtgtaaacca tgggttgtcc gtctgcgcaa cgaaaatacc gtcttctttc agcgcttttg 3223621 cgattcctgc gtagaatcct tttgtaaaca ggtttacagc cggtccgact ggttcagtcg 3223681 aatctaccat gatgacgtca tattgatttt cagattttgc aatgtgcata aatccgtcat 3223741 ctacctgcac gtcaacgcgc ggatcatcca gtttgcctgc gatagaagga aggaactttt 3223801 tagagtattc gataaccttg ccgtcaatat ctacaagtgt cgcttttttc acgcttgggt 3223861 gcttcaggat ttctctgata acgccgccgt caccgccgcc gactacgaga acgtgctccg 3223921 gatttgggtg cgtgaataat gggacatgcg ccaccatttc gtgataaacg aattcgtctt 3223981 tttcagatgt catcaccatg ccgtccaaaa aaagcatgtt gccgaactct tctgtttcca 3224041 ccatttctaa atgctgaaac tccgtttgtt ctgtatgtaa cgtcttgtta accttcatcg 3224101 taatgccaaa gtttttcgtc tgcttctctg tgtaccaaag ttcgctcaat tgtcatctcc 3224161 ctttcgaggc tgtattcatt tattgtaagc gtcttatcag cttttattct cggttgaaat 3224221 ctcattttca cctaaggaaa aagtatagag gatggcgggg aaaaagtaaa gatgcgtcct 3224281 gttctgcgat gtttaaaaac gatctttttt tctcataata gtagaaacat aaaaaaaggg 3224341 ggaacccgtt gtggatgcaa tgacaaataa acggctgaga ctgacgctga aaaccgttcg 3224401 cgcctttatc tttttagggg cttttgcggc cttggcggca gctgctgtgt ttatgactgt 3224461 cattttgata gccaaatacc agggcgctcc ctcggtgcaa gtgccgcaat ccacgatttt 3224521 gtacgcgagt gacggctcaa agctcgggga aacgaactac ggcgaaaagc gctattgggt 3224581 ccccttaaag gacatgaatc cgacgatcgt aaaagcgaca gtggcgattg aagaccagaa 3224641 tttctacgat catcacggct ttgattataa acgcatggcc ggcgcggcgc ttgctgacct 3224701 gaaagcattt gccaaggttc agggtgcaag caccatcacc cagcaatatg cgagaaactt 3224761 ataccttgaa cacgacaaaa cgtggaaacg gaaatggaat gaggcgttct acacgatccg 3224821 tctggaacaa aactattcta aggacgagat attagaaggc tatttaaata cgatttacta 3224881 cggccacggc gcctacggca ttgaagcagc ttcccgcctg tatttcggca agcatgccaa 3224941 aaacctgacg gatgcggagg cggcgctttt ggcaggaatc ccgaaaggcc cttccggcta 3225001 ttcaccgtat gtcaatgaga cgaaggccaa ggaacgccag aaaacgattg tgcggatgat 3225061 ggaaaagcag cagatgatca gccaaaagaa agcggatgaa ttgatcaagg aacctctttc 3225121 ctatcagcct ttgaataaac aagtttccaa gagaaaggct ccttatttct acgacaatgc 3225181 gatgagagag ctggaaaaaa agctcggcat gacacgggag caaattgaaa cgagcgggtt 3225241 aaacgtctat acaacggtag ataaacggat gcagcgcatc gccgaggaga ccattaccga 3225301 aacggttaac gcgggctctg acattcaagt cgggttttca gccattgatc cccgcaccgg 3225361 aaacgttctc gcccttgtcg gcggcaggga ttatcaaaaa agcccgtttg accggacgac 3225421 acaggcgaag cgccagcctg cttcgacgat caagccgttg ctgtactata aagcgattca 3225481 gagcggattt acgccagtca ctttgatgaa aagcgaagaa accgagtttc aaattgatgc 3225541 aaagggagaa acctattctc caagcaacta taacggatac tatgccaaca agccgattac 3225601 gcttctgcag gcgctggcgc tttccgacaa tatttacgct gtgaaaacgc atctttttct 3225661 cggcacgaac aaacttgtaa agacggcaaa ggaattcggc attaccgccc atcttcaagc 3225721 actgccgtcc ctggcactcg gcaccgaacc cgtacgtccg attgagatgg tcaacgccta 3225781 tgccatgctc gcaaatggcg gaaagaaaat cgaaccgact tttatttcaa gagtaacgga 3225841 cgcagccggc cacgtgctgt acgaaaaccc gaatcagcat aaacaggtgc ttgatgaaaa 3225901 agccgctttt gtcacagcga gtatgatgac aggcatgttt gatatcgatt taaatggata 3225961 tacgtcggtt acggggcgaa cgatagccaa ccgcctgaca agaacgtatg ccggaaaatc 3226021 aggaaccacc agcgcagaca gctggatgat cggcttcaat ccgaagctgg ccgccggtgt 3226081 ttggaccggc tatgacaaaa acagcaccat cgactcggtc gaagaaaaaa gctatgctaa 3226141 aaccatttgg gcggacttca tggaggacgc gctcaaaggc gaaccggaaa ccgcgttcaa 3226201 gccgccaaaa ggcgtaaccg gtgtgtacat tgatccggaa acaggctact catcaggtcc 3226261 cggctgcgcc gctaagcatt acacatattt tgtgaaaggg acagaacccg caaacgtgtg 3226321 ctacggggca gaacccgcaa aacaaacaaa agaccggctt ccatccaaag aaaagcccgc 3226381 ttccgagaaa aagtggtggg acaaatggct ggggcgacat cattgaaaat aacccggctc 3226441 ctcggaggcc gggttattcg tatggttcct tcataatcga tggaagaatg ttagacaatc 3226501 gagctgaaca atcagttttg ggataaagtg gtgaatttct catttcttcg gcgctggctt 3226561 tcatctccca gtcgccgact catatccccc taaaaatgaa aaaccccgag tcttgtttcg 3226621 gctcgggatt ttccatgtcc tatttctgta tcaccagttt actcaatgtt tacgaaaaat 3226681 atctcaaata ctttaaaagt tcacaaaaaa ttcataaatt aattgttttc tggaagcagg 3226741 ctcgttttta actcatctga ggaacggtcc cataggccct gatcatgctt tttcagaaat 3226801 tcgcctagta cacgcttcga gctgtcgtcc attttatcaa cgatgatttt ccgtttcatg 3226861 gatttatcca tcagattcac atgctcaggc agtgacttgt agcctcttct gatgcttctg 3226921 tcgaccgtca tttcacaggc tgtcacacca gcgtaataag gcccctcttc ttttctgtca 3226981 atcgttaccc acacaagcca gtatggtttt ccgttcggca cttcttcttt attcgggaga 3227041 aatttaattc ctttttcaac ggtgctgcgg gcatgcatag cgccgatgtc tacgaacgct 3227101 tctttttcct ctacatcaac gaatacggga gaaatgttat caaggctgag tgcccctacg 3227161 ccaaaaccgc cgtgtccgtc tgtcggatca cttttgataa tattaaaccc gattgatttt 3227221 ttcttttttt cttccatgaa gttctacctc ctacaaaagc ggttgaaata tcgctgaaaa 3227281 cagctttaaa atcgaatctc ttcctgcatt gagcatcggc cacagcacgt aagatcctag 3227341 cggtgtcaca aacagcacca aaaatacgat aaagccgtag ctctccgcct gcgtcatttt 3227401 ggcacgcacg cccggcggaa cgagatcttc tataattcga tagccatcga gcggaggaag 3227461 cggcagcaga ttaaataaaa acaagacaag attcagctgt atccaaatag aaaaaaactg 3227521 atccagcccc gtgctgaacg ccgcaagcat ttccattccg tacgcatgca tcaacactaa 3227581 caaaaagaaa ccaataaacg caagaatcag gttactgacg ggcccggcta tagatacgag 3227641 cacaccagca agccggggtt tcttaaagaa acggcgattc acgggaatgg ggcgcgccca 3227701 cccgaatccg gccaccagaa tcaaaatggt tccgaacgga tcaaggtgtt taatgggatt 3227761 cagcgtcagt cttccttgtt ttttcgccgt atcgtcaccg aatttgtatg cgacataagc 3227821 gtgggcaagc tcgtgcatcg taaacgacac aattagcgtg atgacgaggt atggcattaa 3227881 agataacgga taatataaaa aacggtccaa gtgagatatc cctctttctc aaaatgcaag 3227941 aatttacttt attcagtata ctataagaag cctctttttc taaagagagg aaacgagata 3228001 aaggaggatt cagcacccat gccatacgta actgtcaaaa tgctcgaagg ccgtacagac 3228061 gagcaaaaac gcaatcttgt cgagaaagta acagaagccg taaaggaaac aaccggtgct 3228121 tctgaagaaa aaattgttgt ctttatagaa gaaatgagaa aagaccatta tgccgtcgca 3228181 ggcaaacgcc tgagcgatat ggaataatct ctataaagcc ggcgcttcgc gcaccggctt 3228241 ttattatccc tattgagcca gcttcgcaat aatcgccaag aacgtctttt tctcttcggc 3228301 tgttaaacgt tcaaacatgc catcaatcag ctgctggcgg ttttcgatca tttgttcagc 3228361 cgctccccgg cccgattcag aaagagtaat ccatacagtg cggcggtcat tgttatttct 3228421 ggatctctca ataaaccctt cctgctctaa atgattcaga gctgtggtcg tggcagaggg 3228481 agacagtgtg acctccttca aaatatcctt tatggtgcag ctcccatgtc tgtatatgat 3228541 ccgcagaata aaccctctta cattattcac gtgtttcgga acggtggctt catctaattg 3228601 cttcgtgctt ttcaaatact ttgtaagtgc gtgatccagc aaatttgctt ccagtttgtc 3228661 atggtccatg tcaatttccc catttcgaga tgcattcata acatacgaac gatatgattt 3228721 acttattatt ttactgattc cgaataggga aagtcaaaaa agcaaaatgt gaattcacag 3228781 cttttatcct acatgcctcg attttccacc tgtttcacaa gtttatcttt aaaagtttgg 3228841 aaaggaacgt gttcattctg ctgatgtccg aatcggcgga cgtttaccgc attctcctgc 3228901 tcctcatgat ctccaagcac cagcacgtac ggaatttttt gcacctgcga ttctctgatt 3228961 ttatagccga gcttctcatt gcgctcatca atgccggctc ttatccccgc ctgcttcagc 3229021 tccgcctgca cttttctgca atagtctaag tgaacgtgcg aaaccggtat gatttgaacc 3229081 tggatcggtg cgagccagac tggaaaagcc ccaccgtaat gctcgatcaa aatgccgaag 3229141 aaacggtcga ttgagccgaa aaccgctctg tggatgacaa cgggacgaac cttctcattg 3229201 agttcgttga tatatgttaa atcaaatttt tccggcattt gaaaatcaag ctgaattgtc 3229261 gcgcattggt ggctccgttt cagggcatct tttatatgga aatcaatttt cggcccgtaa 3229321 aacgccccat cgccttcatt gatctcataa gagaggccaa gctcctcaag gacgcgtgct 3229381 aaggcacgtt ccgacgcttc ccaaaggctg tcatcgccta atgaatcctc cgggcgagtc 3229441 gaaagctcaa cagaatactc gaaaccaaat gtccgatata cctcatcaat cagccgaatc 3229501 gcttctttga tctcactctc aatctgatcc tcccgaacga aaatatgggc gtcatcctga 3229561 cagaacgtcc gaacgcgaag cattccgttt aaagcgccgc tgtattcatg gcggtgcacc 3229621 tgtccgaatt ccgccatgcg aatcggcaga tcccgataag aatacaggct gtttttaaag 3229681 atgagcatgt ggccggggca attcatcggc ttcattgcga atcttgtatc atccacttct 3229741 gaaaagtaca tattgtcgcg ataatggtcc caatggcctg actgctccca taaccgctga 3229801 ttcatcataa acggcgtacg cacctcatcg tagccggcat ttgtttgcag ctcacgcgag 3229861 aagcgctcca gctcattgcg gacaatctgc cctttcggca aataaaacgg catccccggc 3229921 gcttcttcag aaaacataaa cagccctaac tgtttgccga gcttgcgatg gtctcgtttt 3229981 gccgcttctt ctagcatatg caggtgcgca tccaaatctt ttttcttttg aaacgcaacc 3230041 ccgtacaccc gctgcaggac ttcatttttg ctgtctccgc gccaataagc gcctgatact 3230101 cttgtcagtt tgaacgcctt gatcatccct gtagaaggaa gatgcggccc tcggcacagg 3230161 tcaacgaatt ccccttgctg gtacagtgtg atatcctccc cgcgcggaat atcctttaaa 3230221 atctcaagct tgagccgctc gtctttttgt gcaaacagct cttcagcttc ttcgtaagaa 3230281 acctctatac gtttgatttc aaggttctca tttattatgt ttttcatttc tttttcgatg 3230341 gcctctaagt ctcctgatgc caagcttttc cccagcttca tgtcatagta gaagccgtct 3230401 aaaatcacag gccctacccc caatgacact tcgccgtaca gccgttttac tgcttgggcc 3230461 agcacgtgcg ctgttgtgtg gcgaagcacc tgcaagcctt cttgtgaatc gagtgtgaca 3230521 atcgaaagct cagcatcctc ctccagcttg aaactgagat caacaagctt gccgttgacc 3230581 tgacctgcgg ccgccttctt ttgcagactg gaactgatcg aaccagccgc ttctttgatt 3230641 gtgatgcctt tcggatattc ctggatctgt ccgtccggaa gctgaatgtg tacatgtttg 3230701 ctcattttag aacactcctt attcattgtt gtatataaaa aaacacaccc gtcccgcaga 3230761 tagggacgag tgtgtgatta acccgtggtt ccacccaagt tcccgacaaa tactatgttg 3230821 tcggctcggt gctgtaacgc agcatagacg gcattggtta cttcagttcc ccaatgctgc 3230881 tccaaggcgg taaatgatat tcctaagctg ggaagctctc acctttcctt ccctctctga 3230941 aaaccgtaac tatcattcat gtccttttca tcgcatgtat tcaattcata aaaaaacaca 3231001 cccgtcccac agatagggac gagtgtgtga ttaacccgtg gttccaccca agttcccgac 3231061 aaatactatg ttgtcggctc ggtgctgtaa cgcagcatag acggcattgg ttacttcagt 3231121 tccccaatgc tgctccaagg cggtaaatga tattcctaag ctgggaagct ctcacctttc 3231181 cttccctctc tgaaaaccgt aactatcatt catgtccttt tcttcgcatg tattcaattc 3231241 aaataaaaaa acacacccat ccctctaaaa gggacgaatg tgttgatcat ccgtggttcc 3231301 acccaaattc ccgatcaatt acacatgatg atcggcttaa agatgctgta acgcagcatg 3231361 acggtatcag atacttgttt tccctgatac ggctcaaagg cggtaagctg ctttccctgc 3231421 gttaggaaga tctcagctgt ccttccctct ctggaaaccg taaaaagcat ctcgtgtcct 3231481 tatcagtgcc tgttgtttca ataatttttt atatcttact atatattccc acaaagcgca 3231541 atcagtgatt tacatttttt ctgacgcggc agtcccgtta tgggcagcca gaaacagcca 3231601 tacaagcaat gcagcgaggc tgtatgccgc tcccatcatc aaaaacgcaa acccggcacc 3231661 agcataccaa gtggcggaca gatgaatgat caccccggtt atcgctacgc cgaccaaggc 3231721 tccgatttgc cggtttgcat ttaacgccgc accggcgata ttcgtatgtc tttgcccggc 3231781 agcctgcatg atcacagttg tcatggcagg aactgtaata ccggtacaga ggttcataac 3231841 agacatcaac accgccagct gccaataagg aaaatccgga gaaatcagca caaacaacag 3231901 caatgcaatg atacagctga ccgccattga tacaaacata agctgaccgg cttcaaaccg 3231961 attcgccaga cgggcaaaca gcagattgcc gatcacgaag accgccatca tcggcagcag 3232021 ctccactcca gccataaagg aacttgcccc tcctgcttcc tgcaaaaaaa ggctgagcat 3232081 aaacatgccg ccaaaaaggg cgaaattcag caaaaacccg ataaattggg cagctgagaa 3232141 gcggccgttt ttgtataagg acgccggcag gatgggtgtt tttgcagaaa tttcccgcag 3232201 caaaaacagc acaaatgcca aaaccgctgc agtaaatgct acaagaatca ctggcgagcg 3232261 ccagcccgct gaaggcccct gtatcaaagc ataggaaaga aacccgagag ccatcatgcc 3232321 aagcagatgc ccgatgatgt tcacgcggct gcttttccca ggaacgcggc tgaggattcg 3232381 gtaagctgaa atgagcgcag cagcccctat tggcacattg atcagaaaaa tactctgcca 3232441 gcccgccaac tgtaccagca cgcccccgat aaaaggccca agggctgaag cggcggaaac 3232501 aagcgcggcc cacagtccaa acattctcgc ccgcgcccgc tcatcaaggt aagaggcagc 3232561 caaaaggctg agtgagcttg gcataaacaa agctgcccca attccctgta tgagacgtcc 3232621 ggcaatcagc atctgcccat ttatagatgc agcgcataga caggaggcca taacaaaaac 3232681 ggctagaccc aagatataga tcgtcttcga gccgaaacgg tcagccaagg ctccgcccgc 3232741 cagcagaagc gacgcaaaag taagaatgta cccgtccaca acccacgtta cacctgaaag 3232801 tgacattgaa agagtgtttt tcatatcagc catcgccaca ttcacaacgg tcacatcaag 3232861 agttgccatg aggaaaccaa gtgcgagcac gatcagcacg gatatgcctg ttgatgatgt 3232921 tgattcttgt atagacccgc tatttttcat tacaattgcc ctttcacttg cttgattacc 3232981 caatcatcta ttttttcaag atcatacaat tccccgactc tgtccataac atgctgcaag 3233041 gattcttctc tcataagatt ggaccattta tcctcgattt ccgccatgac tgtctccagc 3233101 acacagtgac tttcaccctc aaatacagat tgcagcaagc ctttcccctg atacatcgaa 3233161 cctctgcctt cgaccgcttg ataaacatca taaagcgtaa tgtcagccaa aggcttcgtc 3233221 agggtaaaac cgcccttcgt ccctggtaag gattctgcca aaccggcttg aaccaatgtt 3233281 ctcatcagct tcttcaagta agacggagac acgcgcaatc gctggcttat agcctctgac 3233341 gtcaaagaag cctgtaccgg cagccgtgac agtaacagca gcacagaaac cgcctgctcc 3233401 attcctgatt tcattttcat cctattcact cctgattcat tatggataac tattatccat 3233461 aatgaatctc ttagcagctt ttgtcaataa aaaaagcaaa agaaacggat catttctttt 3233521 gcttggtatg gttaacaaat ctgcttcagt tcctctatgt attgaagcgc ttcgtcatat 3233581 tcttcatttg tatatttttg cttgcttttg atggtaaaga ctttttcttt cttttcctca 3233641 tcctcaagcc cgtcaaagta aaggatcgtg gaaaccagct ctaaaaaccg tgatgaacgg 3233701 ctgtttacac tgtcgatata gcctttcata tccggcatgt ccagatcagc atggtctaaa 3233761 aatgcggagc ctgtctcagt cagcgaatac cggtattgaa agtagccgcc ctttttttcc 3233821 ttcacctcat gcagaaatcc aaggttgcac agctcttcaa tctggagcgt cagttcctct 3233881 gaatatggtc cgtaaaagtg aaaatcatat ttctcataga aaggaaactg cattttcttg 3233941 gcgatataaa tcattttctg cagcttcttt cgcccgatga tttctccaga atccgagaac 3234001 accttcatca gttttgcatg ttctttcaac aaattcccga catctccttt ttccttcttt 3234061 ccaatttcta tgtcagtccc agcagctgcc ggattttcat tttcgcttcc ggatgtttag 3234121 tgccgtcaca aatcaagtcc tttggatagt acagcttgtg gtccgtccgc cgtttacctg 3234181 agatggattc cacaatagcc gactgtctgg acagctcttt aatttggccg ttttgcgtca 3234241 agagatggat cggcagacgc tcctcttcct ctcctggtcg gtaaaaatcg tatggcagat 3234301 ctgatgaaga atcaacgacc aaataatagc tcggatcgat ccccgcctct ttgaacaatg 3234361 aagtcagctc aaaataagcc gacatttctt cattcggatt gaattcaacg tattggaaaa 3234421 gctggcggtt aatgaatctg cggcacaagt cggataaaat cgcgtcttct tcatcctccc 3234481 aggcctggaa gtaatacaaa ataatagatt catccagctt tacataatcc tccagtgtca 3234541 attttccttc aaaaatagaa tagaaatgaa ccggagcgtg agtgaagaca tagccttcat 3234601 cgtgcagctg cttcgccctg tgaagaatct tcgttaaaat gacctctgca cttctagtca 3234661 caggatggaa gtagacctgc cagtacattt ggtaacggct catgatatag tcttcgacag 3234721 cgtgcattcc gctttcttta atgacgatct gatcctcgcg cggccgcatc acccgaagaa 3234781 tccgctccat atcaaaatgg ccgtagctga cgcccgtata atatgcgtcg cgctggaggt 3234841 aatccatgcg gtctgcgtca atctgactcg aaatcaggct gaccacttgc ttgtttttat 3234901 atgttttggc aatgacttca gcaacatcct gagggaaacc cgggctcacc tttctgagca 3234961 cctgattaac ctccgtgtct cccaaaatga tacctcttgt aaaatcctcg tggtcaaggt 3235021 gaaagacctt ttcaaatgaa tgcgagaacg gcccgtgccc gaggtcatga agcagcgccg 3235081 cggccaaaca gagttcgcgc tcactgtcat cccattcagg gcggccttta aagacgtcat 3235141 caaccattct tctgacaatt tcatagacac cgagagaatg gttgaaccgg ctgtgctcag 3235201 ccccatggaa cgtcaaatag gtcgttccga gctgcttaat tctgcggaga cgctgaaatt 3235261 cacgggttcc gatcaaatcc catatcagct tgtcccgaac atgaacatag cggtgcaccg 3235321 gatctttaaa cactttttct tctgataatt ttccatttgg atacgccatc gtcattccct 3235381 ctttttttta gccgtgtttc tattatatcg actctattct ttgaaaacat ccttgaattt 3235441 gcccggcgat ttgttccatc ttcatgaaaa acacatcttg tgaagcaaaa aagcctgacc 3235501 tgagggccga ggctaagaaa aaatatgttt ttactttttt attttctttt ttactttgtc 3235561 aatcagctca tcctctgtcg gagctgacag cgggcgattg ttcacaaaag caaatgattt 3235621 tttccgtccg ggcccgcaat aagattggca tcctacctca acctttgcgt ccgggtccac 3235681 ttctttcaaa cgcggcagca atgttttgat attagtggct tggcaatcat cacacactcg 3235741 aaattcatta gccatgacgt acgcttccct tcatttctat gttcatctat gtgaataacc 3235801 taaaatcacg tttcaaaaaa aatcacatca cacttcattt tacaaggatt cgactgttcc 3235861 tgcaagccgc tccatccttc gtatctccta ttctttcagc caatttgtat aaatattttc 3235921 caacctggac attctaatac catgaaaaga aaaatgggag ttgagataaa tgacaaaaca 3235981 gcgacaagac gcttggtcag aggaaaacga tctgctttta gccgaaacag tgcttcggca 3236041 tgtgagggag ggcagcactc agctgaacgc ctttgaagaa gtcggcgata aattaaaccg 3236101 gacatccgca gcctgcggat tcagatggaa cgcagtggtc cgccatcaat atgaaaaagc 3236161 gcttcagctt gcgaagaaac aacgaaaaca gcggatgaga gcgctcggaa acgggcagcc 3236221 cgcgaaaaaa agattattat atcagcctcc tgccgttgat cctgaaatca ttcaagaaac 3236281 cgctgcagaa gagccggtta aaacggaaac accatctgtc gaaaatgagc aacctttaat 3236341 gtctggcgaa cacatgcctt ttgttgatga aagctttaag gaagagttag ctagtctatc 3236401 acacttattg tctcctcaaa cgcctgcagc tgcgcctgag atgacgatga atgatgtgat 3236461 ccgcttcctg cagaattacg aaggcaatca cgagcaatca tcagcattaa aaatggaaaa 3236521 cgagcgttta aagaaagaaa atcaggaatt gcaaaacaaa acagagcagc tagaggcaga 3236581 agttcaaaag cttgaaaaag accaaaaaac gatccaagaa gattatgaaa ccttggtgaa 3236641 aattatgaac agagccagaa agctagtttt atttgaagaa gatgaacatg cctctccgtc 3236701 cttcaaaatg gaccggaacg gcaatttaga aaaattagcg gaatgacata gaaaaatccc 3236761 aaaacgggca gctgttttgg gattttcgcc atgtgcaaaa tccccttttc tattgagaaa 3236821 agagaatttc ctcattttgc agccggatca gctattcttg taaaatgagg ccaagcttat 3236881 gtgaatctat taagacatgt gagctgcctc ggccgttttt tgtttccgag gcgcagcaga 3236941 aatgaccaaa agccccagca tcataagcgc aatgcccagc cacgaggaag gcgaaagcat 3237001 ttcccctatg aaaaacacgc caagcaatga agccgtcagc ggttcagcta aagacagcgt 3237061 gaccgccgcc gaggccggaa ccccggtaag ccctttcgca aacaaaaagt atgcggcaca 3237121 tgttgcaatt aacccgatgt aaaggcttgt tcccagtcct ctaggggtca atatccacga 3237181 gatatctaac tgccataata gcggcgtcag caagatggcg ctgatcatga atacaacggc 3237241 ggaggtcgct cgcggaggct gggttttcat catcgcttta ctgatgagcg tatagcctgc 3237301 aaaagaagca cccgctccaa gcgccataag aacaccagcc acatcaatcc gaacattgga 3237361 actgtcggaa aacagaagcc agcaacccgc taaagccagc acagtcgcaa tccaccagga 3237421 gtttcgcggg cgtttcttca atacagccca ttcgagggtc ccggcaatga taggcgcact 3237481 gccgatggca atcacagttc ccactgcaat tcccgtttct ttaaccgctg tgaaaaacag 3237541 cggctggtaa cacgccatac aaacagcggc taaaaatacg agcggccatg cccaattttt 3237601 cacgtgaagc tcccggctga tccaaaccgc aagcagcatg gcgcttcctc ctattaataa 3237661 cctgaacgct ccaaatgcca gcggtgtggc gctttctgga gccaatgcct gaacggttcc 3237721 cgtggtcccc cagaaaaaag ccgcaatcaa tacaaaaagg ctgtaaatat tccccttcat 3237781 ctgcctctcc cctttaatat ggatgctgat gtcattttat cgtttttctt tttgtcgtgg 3237841 ttatctgtat gtaagaagga cttatctgaa aataagatta ttgaggtaaa atgccgcttg 3237901 agataaaaaa tgcatgccgg catatacagc cggcatgcga agaacgttca cccaaatacc 3237961 tttgcattcc gctcagccat ccggacgagg tttttctcaa attccatttc ctcatcaatg 3238021 gacagtccag ctgaataaag atgggtgctt aacgctttta attccgtcaa taaagcgaac 3238081 attaagtctt gtacggagat gtctttttga agaagctcac ttaaggacgc catcgtttcc 3238141 ggacgtattt ccggatagac gcctttttta tcgttttgtt tgtctttcag cgccgcttga 3238201 tagaatcgtc tgatcaagtc ggccctttca ctgccgcttt tatctgcaca gagataaatt 3238261 tgaacagcga ctccgccgcg aacgcgtctc tgagagatgc cggcgaactt tttgccattt 3238321 atactgaggt catagctgcc gggacaataa gacccttcaa tttcataggc ttcgatcttt 3238381 gcgttgtacg gtctcagcat tcgtctcatc agctcgacca tcgcttcata tcctttgtct 3238441 atatcgatgc ctttcttttc gtcctcgaat atgagagaga tatttaaaac accgtcatcc 3238501 aatacgacgg caagaccgcc ggaattgcgt acgatcacac ggtatccttc gctctccagc 3238561 aaggagatac catcctgcaa aaacgggagg cgtgtatcct gtattccaag gacaattgta 3238621 tcgtggtgca cccatgagcg cgctgtcgcc ggcgacacgc cttttccgac ggacatgcat 3238681 agcgtatcat ccattgcgaa ggattgcttc gcatcaaata aagggccgag actggattgg 3238741 tcaatgactc tccatttcgg ctgcatcagt aaatcaatcg gttggtttgc catctatgta 3238801 aaaccctttc atgttaggct tattgaacga aaactattat atcatttcag cagctgtgat 3238861 tgataattgc ttttcagcat cgtaataaaa atttctttat tttttgtatt ctccatgaga 3238921 ggagaatgaa tgtaagacag cttgcgcttt aacgagaaat tattaatatg cagaattgaa 3238981 atttcgcggt ggatcaaatc cttacgcagc acgcttctgg atagaaccga aagtcccatg 3239041 ccgttaatca ccgcttcctt tacaccttga ttgctgctga tggtaaacat tgatttcggc 3239101 cgaagtccat ttgaactgag tacatgatcg agatattctc tcgtcccgga gcctttctct 3239161 cttgtcaccc acgcttcgtt ctgcaaatcg ctgatcgaaa tctctttccg cccggcgagc 3239221 ggatgctgat ttggagcggc aatgcacatt tcatcctcca tgaacggttc aatttccagc 3239281 tcattctcgt ttgtatgtcc ttcaatcagc ccgatatcag cctgaagcat ccgcacacgc 3239341 tcgctgacct cctctgtatt gccaatcatg acatctagat tcagctctgg atacagcttt 3239401 tgcagctggg ccaatagcgg cggaagaata tactcaccga ttgtaaagct tgcagctatt 3239461 ttcaattcac ccttcacata gtgatgatgc gcatagattt cagccttggc ttgttcgtag 3239521 agaaacacca tttgctttgc tctttgatat aaaatgtctc ctgtcggcgt tgtcgtaaag 3239581 tgttttggcg acctgttcag aagagccgtt tgaaattctt tctcaagatt tttgatatgc 3239641 agactgacgc tgggctggga gatcatcagc ttttccgccg cttttgtgaa gtttttttct 3239701 tctaccaccg ctataaacgt tttcagcacg tcgtaataca aaaaccccac ccctgtcatt 3239761 aatgaaatat atggttatga ttagttttct ttattgtact catatcatcc gtcttggtaa 3239821 agaagggcta tacagaagcg caaaaaaggc agccctcggt cgagagctgc cattgtcttc 3239881 aattttatta cagtgcttgc gccgctgtaa ttaatgcgag attgtaaaca tcttcagcgt 3239941 tacatcctct tgaaaggtcg tttacaggca tatttaaacc ttgcaggatt ggtcctaccg 3240001 cttcaaagtt gcccaaacgc tgagcgattt tatagccgat gtttcctgct tcaagacttg 3240061 ggaatacgaa tacgttagcg tcccctttga tctcggaatc cggcgctttt ttctcagcta 3240121 cagatggaac aaatgcagca tcaaattgga attcgccgtc aagtgtcagt tcaggcgctt 3240181 tttctttcgc gattttcact gcatccgcta ctttttctgt ttcatcagat tttgctgagc 3240241 cttttgtaga gaagctgagc attgccacgc gaggctcaat gtcgaacatt tttgccgtat 3240301 tggcactttc gatcgcaatc tcggcaagat cttggctgtc aggtgcaatg ttgatcgcgc 3240361 aatctgcgaa tacgtattgc tcttctccgc gagccatgat gaacacgcct gaagtctttt 3240421 tcacgccttc ttttgttttg atgatttgaa gagccgggcg gacagtgtca gcagttgagt 3240481 gagcagctcc gcttacaagt ccgtctgcaa gtcctttata caccagcatt gtaccgaagt 3240541 agttctcgtc taataatgct ttacgagcct gttcttcagt cgctttgcct ttgcggcgtt 3240601 ctacgaatgc ttgtacaagg tcttccatgc cttcatatgt atgaggatca taaatcttaa 3240661 cgccgcccag cgtaaggttc aattcttttg cttttgcttg gatctcattt tcattgccga 3240721 tcacaatcgg attcagcact ttgtttcctg caagcttgct gaccgcttct aaaatacgct 3240781 cgtctaagcc ttcaggaaat acaattttaa cgtcttttcc agctactttt tcttgcactg 3240841 ttgaaaataa atctgccaca ataaaacctc ctcaaaaagt tacaaaaacg ctttctttta 3240901 ctagcatact cttcttccaa tcaaattcaa acagccaact ttcattatag cgctttcata 3240961 aaaaaatctt atttttctaa ctaatttaag tgactcaatc ttcccttata ggttcttcta 3241021 ttttgatgga gttatacgga agggatgttc aaggtttctc cacagtagaa tcggataaac 3241081 tatggtatag tgaaggcaat catgaaaaga taatgggagt gaagataaat gagtgaacag 3241141 caaatgacga atgaagcggc aaaaacgctt gacggctggt atgcgcttca tgatttccgc 3241201 acaatggatt gggcttcctg gaagcttctg tccagtgatg agcgccaatc tatcatacat 3241261 gaattcaccg ggttgcttga aaaatggggc gtagcccaaa aagaaggaaa aggatcgcaa 3241321 actctttaca gcatcgtcgg ccaaaaagct gattttatgc tgatgatcct tcgtcctaca 3241381 atggaagaat taaatcaaat tgagcttgaa ttcaacaaat caagacttgc tgagttcacc 3241441 attccggcat actcctacgt atcagtggta gagctgagca actacttggc aagcggtgac 3241501 ggcgatcctt atgaaaatcc gcatgtgcgc gctcgccttt accctgaact gccggaatct 3241561 aaatatgtat gcttctatcc aatggataaa agaagatctg gcaacgacaa ctggtatatg 3241621 ctttcaatgg aagaacgcag aaacttgatg agaagccacg gtttaatcgg ccgcagctat 3241681 gcgggcaaag tcaaacagat catcaccggc tctgtcggct ttgacgatta cgagtggggc 3241741 gttacattat ttagcgatga tgtccttcaa ttcaagaagc tagtgtacga aatgcgtttt 3241801 gacgaagtca gcgctcgcta tggcgaattt ggttcattct ttgtcggcaa tcacctttcg 3241861 cttgatacac ttcctcaatt cttatatgta taatatcccc gagctcgttt attgagataa 3241921 ggactgatcg gccttctgct caagtttgcc gtacttttta tatgcgaata cactgagcac 3241981 aaatccgagg actgtgatgg cggcgcaaat caatccgaca gctgcatagc cgtatgccac 3242041 atatacgggt cccattaaag cagaacctaa tgtcacggcc agattcgagg cgagactgta 3242101 aaacaccatg acttttcctc gatgacgctc tgagcagtca ctcaaaatgg tgctgagcag 3242161 cgtcaccgtc aaactttgca ttaatcccca aataaatagg ctggcgatta acagaaacat 3242221 agacgccggc gcatatggta aacacgccag cagaacgctg atgaccccca gcgcaatcaa 3242281 aagggagcgc atttttccga tgcggtcggc tatctttcct gtaatcacac tcatggaaaa 3242341 cccgattcca taaatcatga taaataagcc cgcagccgtg tttcctccgg taaaaacgtc 3242401 ctgaagatag gtgcctaaaa aggaatacat accgtaaaaa ccaatcatat tacaaaaggt 3242461 tattgtgata taaacaggta cacgagggac tttcagcgca tcccggaatg ttcctgcggg 3242521 ctcttctatt tcttccttgc cgctgttttt atgttgggca tggcggcgca tttcaaggag 3242581 aatcagcaga acaactaaaa cacccatcag ggcgaaaatc caaaacgtcc atctccaatg 3242641 caggacgccg ccgataaatg atccgagcgg cactccgaaa atcagcgcca gcgaccagct 3242701 tgaaacgatc agtcccatca ccttgccccg gtatgtataa ggaacacgat caccgacaac 3242761 tgcgtaagcg gtcggaacaa acgctcccgc agccaatccc gaaagcgccc ggcctaaaaa 3242821 gaagaaaaaa atattttgag ctaaagcgca tatcaccgtt cctatgataa aaatcataag 3242881 cccggccaat aagctcagtt ctctggagta tttatcgcct aatggaacca aaagcggcgc 3242941 accgataaaa atcataacgc cgtaaatact gatagataac gcaaggacgc tgacatctga 3243001 gctgaaggct tttgctaaat ccggcagcag cggtgagatc acaagctctt cagatccggc 3243061 tgcaaatacc cccatcgtta aagccagtgc caacaataac ggaaaatgat gttttgtttt 3243121 gatgtcattg ttttgattgc tgttcattct ttctcaaaca cctcttccat aatcttctta 3243181 tcataaagtt gtattatagt ttagcattgt tttttctcta tttacaattc gaacgaaata 3243241 tttataagtt ttattatttt catttaaatc ccattatata tttctatatt tcattctaaa 3243301 aatacatgag gatgtaacac gtaaaaaaag ctctccggcc tcccggagag ctttttctat 3243361 tgcgcctctg tctgcttttt ttcaatcgtt tcatgattta tacgcttttt gatgcttaga 3243421 tgatagtatg cataacagaa aataatgatc ggcacaccgc agtataagcc aattctttga 3243481 tccggaatga aaataaggct gatcaacacg cagccatata aacaaaatcc gagaatcggg 3243541 actagcggat aaagcggcgt tctgaactcc agatcattca catttccgcc ttctgccagg 3243601 aaacgcctgc gaaagaaaaa ttgcgacgca caaatggaca tccacgcgac aactgtcacc 3243661 atgcccgaga ttgagataca ccataaatac actgtttctg cagccatgac acttgtcagc 3243721 agcgaacagc ctgaaatgcc tagcgtaatc agcagggcat tcatcggcac gccttttttt 3243781 gtcagtctgg tgagaaagga gggacccatt tgatttgatg aaagtgacca catcatacgc 3243841 gacgccgcat acaatcccga attagcaaca gataaaatgg ccgttaagat gacaaagttc 3243901 atgatatctg ccgaaaatgg gatgccgatt tgatcgagta ctgctacaaa cgggctttca 3243961 atcacccccg ccgttttgta cggaaggatg gcaaccaaga cgaacatagc gagcacaaag 3244021 aaaaacagcg tgcgccaaat aacatttcga atggactttg gcagtgtttt ttccgggctt 3244081 tcactttccc ctgccgcaat gccgacaagc tccgttccct ggaacgagaa gtttaccatg 3244141 accagcgtaa acataacggc cagcacccca ttagggaaaa gccctctatc agtcataaag 3244201 ttagacaaaa agggtgtctc ctgtccgcct ttaaagtcaa tcaagccaaa cacagcggct 3244261 ccgccaatca caataaataa tatgatcgcc gccactttga tgcttgaaaa ccaaaattcc 3244321 atttccgcaa agcttctgac agagagcgca ttaatcaaaa agatgacgat gccgaacacg 3244381 aggcaccata tccagatcgg aacggagggc agccaccttt gcatcaaaat gcctgctgac 3244441 gtcagctcta accctactgt attggcccag ctgaaccaat acagccagcc aatcataaag 3244501 cctgtcgact gtcccagaaa tttagtggcg taggcctgaa acgatccggc caccggcatg 3244561 gcaacagcca attctcctaa acaaagcatg acgagataca ttaaaaatcc gccgatgata 3244621 tacgcggcaa tggcgccgag cggtcccgcc tggctaatgg taaagccaga gcctagaaac 3244681 agcccagtgc caatcacccc tcccaaagca atcataaaca aatgcctgct tttcatgctg 3244741 cgctgcaatt catttttatg attctgcatc atccttcccc ctttggttct tttgccgtga 3244801 tggtcatccg gtagctttgc aaaagatgaa cggtggtttg ctgtatgagg agaggcaata 3244861 catgaaatgt gtacggttta tagactcgtt ctgtccattt atggccgtct tttccgtaca 3244921 cgcccatatt aatggatgga atattcagct tgcgtatgtc tttgaacgga atggtcccaa 3244981 tcatattcca cccagggaag ttcctgataa aagaatcaat ttcgccatcg gtttcgtgca 3245041 gtgataaaaa actgccgtct gccaagtagg ggaaaaactt tttgaagaca aatgtttcgc 3245101 ctgtcgattc agcggttttg tcagccgctt ctttaatcac atgctgcaaa agctgatctc 3245161 ttgcgctatc ttctttcaaa tagttatgcg gcaggtaagg aggtgcgtaa aatagaatga 3245221 cttttgcgcc ttgatcgggg tcaagctttt gaagctcttc gattgcctga aagcatctca 3245281 tgcgaagttc aaggtgctcg ttggctttga atgtctgctc gatacactgc tcgggatcta 3245341 ttccccggtt tctcagcttt tctaagtatt gctccaggct atacacttga atgccccatg 3245401 ataaatgttt ctttggcagg ttggctcttt ttacatattc ttcgtaataa tctgataatt 3245461 tttgttctgt ctcccggcat gcttcctcag tgacttcaat aagcaaatcc atcatttctt 3245521 ttgctgttct ttcataaata aaacaattga aatacaagct ggtgctgaca gccgtttgca 3245581 cattatagga ttccttgtta tcacgctgat acaaacagga tgggggcaga accaactccc 3245641 cttcaacctt ttctgccaga tggatgttat tgtggagacg gcttgtgatt tcagatgaaa 3245701 tgaaatttgg gtcaatccct gccagtgtat cgccaacatg gacttcacgc ccgtaaatgt 3245761 aaaagcaagg caacagtttt cccgcggctc cggtatagat atatcttgtc tgatcaccat 3245821 cgtaaagcgg ggtaataaaa tccgtattaa tagcagccaa atagtgaagc tgtttttctt 3245881 tttttagccg gttcagctct gaaatgctgg cgagaatgcc cgaatgctgg ctctcctcat 3245941 cgggattggc cataaacaat acatttcccg gcaacgtctc aaggttctcc gaaaaatgca 3246001 ggagattggc taaatgcacg gcgatgccgc tttgcatatc gacagatcct cttccgaaca 3246061 tccactcgcc tgatttggca tcccgctgaa catcctgatc gaactcatag cggctgaaat 3246121 actcggccaa tttctcacaa tcaaaagcga tatcctttaa agggccgaaa tcttcaattc 3246181 caactgtatc cagatgggca tggtaaatga ctgtatttcg gctttctcca tgtcctttaa 3246241 taaacgcaaa aatatttttg cgtttgtatg ggtcattggg aatggcctgt tcccacacat 3246301 gactggggtt ttcctgaaaa taaggatagc tcgtgatcac ttctttgatg aaatctgctt 3246361 ttgtcccttc tccaacggtg ccgttcacgc tgctgaggct gaccagagat gctgtcagcg 3246421 cctccactct ttcagccgga ttcatgtgac tgatttttgt atactgcata aattgtcctc 3246481 ctgatcaaaa agttgaaatc gtgcgatccg ctaaagaatc gcacgatttt atttctctca 3246541 aatcaaaaag cttcggacgt tgttttggct tgcatatgaa gaattaagta atcgggaccg 3246601 cctgcttttg agtctgttcc tgacatatta aaaccgccga acggctgata gccgacaatt 3246661 gctccggtac atcctctgtt aaaatatagg tttccgacat ggaaatcctc gcgcgcccgt 3246721 tcaatgtgcg cacggttttt cgtcagaagc gcacctgtta atccgtattc cgtgttattg 3246781 gcaatctcca gcatatgatc gaaatcacgc gctttgcaaa tcgcaacaac cgggccgaaa 3246841 atttcttcct gcatcaagcg ggcgttttca tcaacatctg caaagatcgt cggctgaata 3246901 aagtagcctt ttgaatcatc gccttctccg ccggccaata gcttgccttc agatttgccg 3246961 atttcaatgt atttcatcac tttgttgtag gatgcttcat gaatcacggg acccatatac 3247021 gtatcaggat cttctggatt gccgacagtc agcgttttgg tcagcgccac agctttttcc 3247081 accacttcat catacacatc ctgatgaatg accgcgcggg agcccgcaga acacttctgt 3247141 cctgaatatc caaatgctga atacacgata gaggatgcag caaggtcaag atcagcgtcc 3247201 ttgtcgacaa gcactgtgtc ttttccgccc atttctgcaa ttacccgttt gagccatttt 3247261 tggcccggct gcactttggc agctcgctca taaatccggc agccgactgc acgggaacct 3247321 gtaaatgaga caaaccgtgt cttcggatgc tcaactaaga aatcaccgat ctccgcacca 3247381 tctcccggaa tgtaattcag aacgccgttt ggcagacccg cttcctccat gacctcgaca 3247441 aattttgctg ccactaccgg ggctgcgtca gccggtttta agagaatcgt atttcctgtc 3247501 acaatcgctg ccaccgctgt tcccgccata atcgcgagcg ggaagttaaa tggagaaatg 3247561 acgatgccga cgccaagcgc ttcgtaatga tattgattga cctcgccagc acggctcttc 3247621 accggagccc cttccttgag ctttaacatt tggcgcgcgt agaactctaa aaagtctatc 3247681 gcttcagccg tgtccgcatc tgcttccttc cacggttttc ctgcttcctt cacaagatag 3247741 cttgaaaatt catgctttct tctgcgcaaa atagccgctg ccttaaagag aatatttgcg 3247801 cggtgctccg gtctttgttt tttccaggaa tcaaatgcct gcaatgcggc ttgcatcgct 3247861 ttttcagcaa gctcttgatc cgctgtagac gcgtacccaa tgatctcttc tttatttgcc 3247921 gggttaatag aaatgatttt gcggtccgtt tcaatttttt ctccatttat gacaagcgga 3247981 taatgcttgc cgagctgagt gtttacaaag gccaatgact ccccaaatgc agttttattc 3248041 tttgcttccg taaaatcggt aaatggttcg tgcgcgtatg tgactgtcat atgtagtccc 3248101 cctcgtgtta tgaaatatat cttcgcatat gaataaaaat gcaagaatca tgccattttc 3248161 ttgtcttttg ctgaaaaaac ttgttgaatc gaacagaaat ttgtctaaca ggtgatcacc 3248221 tttctctttt tccgatcttg aacgcaaatt tattttgcgt tttttgctct ttacgcaaaa 3248281 aacaaatgca aaattatttt gcggaggctt ctcaaattag acccatccgc ggaaacgcga 3248341 tgcttctgcc gattttctga tgcccgtcat gtaagccgcc aaacgcatat ccactttatg 3248401 tgttgccgct gtttgataaa ttgtttcgaa cgagctgacc atgacgcttc tcagtttttc 3248461 tgcaacctct tcttccgacc aataatatcc ttggttgttt tgcacccatt caaaataaga 3248521 aaccgtgacg ccgccggcac tcgctaggat atccggcaca agcagcacgc ctctttcatt 3248581 caggatctta gtggcatcaa tggttgtcgg gccgttcgcc gcttcaacga cgattgacgc 3248641 ctgaatgtta tgtgcgtttt tggctgtgat ttgattggag atcgcggcag gcactaaaat 3248701 atcgcaatcc ttttcaagca gctcctcatt tgtgatgacg tcagtaaata aattggtgac 3248761 cataccaaag ctgtcccgtt tatcgagcaa ataagggata tcaaggccgt ctgggttgta 3248821 gagcccgcca ttggcatcag aaatcccgat caccttcgcg cccgcatcgt gcatgaattt 3248881 ggccaggaag ctacccgcgt ttccaaagcc ctgtatgatg atgcgcgcgt tttgcagctt 3248941 gatccctttt ttcttcaccg cctcttcaat acaaatcgtg acgccctgtg ccgtcgctgt 3249001 ttcccgtcct tgcgatcctc ccaaaacaag cggtttacct gtaataaagc ccggagaatc 3249061 gaattcccgc agccggctgt actcatccat catccacgcc ataatctgcg aattggtgta 3249121 cacatcggga gctggaatat cctttgtcgg accgacgatc tggctgatgg cacggacata 3249181 ccccctgctc agcctttcca gttctccaaa tgacattgtc cgcggatcac aaataatacc 3249241 gcccttcccg ccgccgtaag gaagattggc aatcccgcat ttgagcgtca tccaaatgga 3249301 taatgccttt acttcctctt cattaacttc tggatggaag cgaacgcccc cctttgtcgg 3249361 accgacagca tcattgtgct gtgaccggta gcctgtgaac actttgacgc tcccattgtc 3249421 cattttgacc ggaatgcgga cagtgagcat tctctgcggc tctttcatga gttcatacat 3249481 atctcccgga taacccagct tccgaagggc ttccttaatg attgtttggg tagacagaaa 3249541 taagttaaga gcttcttttt cttcatcttt cgagacttgc tttgctgaca tctttttcac 3249601 ctcattgttt ttttggccgg ctgtaatgta agcgctttaa aaaatcagcc cgccaattcc 3249661 tttcttcatt ggattcaccc ttatcatcat gcaagatccg taccagcttt tgaatccaca 3249721 aaaaaagaga ctgaaaacat ctcagtctct gactacaaat ctatcgatta acggggatca 3249781 atcaccagct gcgtttcagc ataaaaactg ccgattccca aaccgtttac tacatcgcct 3249841 ttaatcgtgt aagtgcctgc gcgaggaaga gttttacgca ccatgacaag gtcaaattcg 3249901 gatgcgccta acaaatcaag cgtaagcggg agtctgactg tttttccatc gtttaaaatc 3249961 tgtgtttctt tcagtgttct tccattcact gaatctcttg tcgtagcatg aaacccgtca 3250021 ggaaattgaa attctaccgc tccaagagaa agcaccgcat ttggtttata tgtcacttca 3250081 atatcagaaa tggtccactc tttcgtgctg ttaactgttt ttgcctcgat tgatgcagac 3250141 tgtgcatgag cttggcccga aggaagtaag attgatagta aaacagctga actgatgaat 3250201 aatgaagata cgaatgaagt tctttttagc atgacatttc cccctaattg attgttgaaa 3250261 tttggccaga gcgtcctctg cagaaaaagc gctttttcat aattcgcgaa ttaccagttc 3250321 tttttcttaa aaattaatct atcatcattt tccatggaag taaatgtttt ttaaggaata 3250381 ttaacacttg gaattcaatg agaattcctt cctgtttata caaggttcaa atggacgatt 3250441 tccctctctt tttctagtaa catctgcctg acattttata tcttttatcc tattttaaaa 3250501 aagggcaaaa aaagtcgaag atgcctctgc tcttcgattg atcacgttcc tatttttatc 3250561 tgaattcagt gttccagtta aaaccgatcg tctcatcatc ccacggaatt cttttttcat 3250621 caggctgatc cgggttatac gacatggtgg taaaatagat aattgtcagc ggcgtctctc 3250681 ccagcactct atatccgtga gccacccctt ttgggattaa taacagcatc gggttgtctt 3250741 cgcccatata atagacgtcc gtttctcctt ttgtctttga atcctctcga agatcgtata 3250801 ggacaacctg agcgtggccg gttgggaaga accagagatc atcctgcttc tcatgataat 3250861 gaaatgcctt aatcacaccc ggatagcttt tcgaccaaga ggcctgccca aaatgctcaa 3250921 ggagattctc atcgtcccgg accagctcag caaaaaagcc tctgtcatcg ctatgcttca 3250981 tcaatttttt caccttgact ccatcaatca cacgcactgc tcctttcctg caaatactct 3251041 cgtaacgctt cccgccagtg gcgggggcgg atgccggctt cttcaatagc ccgatggctc 3251101 agcacagagt atgccggacg gggcgttttg ttcccgtatt cctctgtcgt tacagacaaa 3251161 atggctgttt ccagcccgct ttcttccata attgccgtcg caaactcata ccagctgcat 3251221 atgcctgaat tgctgacatg atagatgccc ggcggatggc tgaacagctt gatgaccgct 3251281 tctgctaaat ccttcgtata agtcggcgaa ccaatttgat cgctgacaac ccgaagctct 3251341 tgtttcgttt cagcaagttt cagcatggtt tcaacgaaat tactgccgcc atgtccgtac 3251401 acccacgatg tcctgatgat cgtgctgtct tttgtcgtta atcgtatcag ttcttctccg 3251461 agccttttgc ttttgccata aatggttttc ggatcgaggg gatcgtcttc cctatatggc 3251521 tgggttcctt tcccattgaa tacatagtcc gtgctgatat gaacatattg agctccgatg 3251581 cgggttgact caagcgctgt ataataagcg ccgattccgt taatcaagta cgctttatca 3251641 agctctttct cgcattgatc aaccgacgta aacgcggcgc tattgaccac gatatccggc 3251701 tgataatggc caaacgaatg ccgtactgag cgctggtcag caatgttcat catcttcttt 3251761 gttaacgcaa tgacctcata tccggcttgc ttcagctggc ggcatagttc caagccaagc 3251821 tgtcctcccg ccccagtcac caataccttt gtcaatcaga tcaccttctc atcggtcatt 3251881 gtctgtatac cactgaatcg tacgcgcaat gccttcttca aacgtcactt cctgccgcca 3251941 gcccagttcg tttttcagct ttgatgcatt gatcgcatag cgccggtcat gcccttttcg 3252001 gtcttccacg tgggcgaaca attcctcaca gcccagatgc ttcaaaatga cactcgccag 3252061 ctctttattc gtgcgttcat ttccgccgcc gatgttatac acctcgccgt cggtcccttt 3252121 ttctaaaatc agcttgatcg cgcggcaatg atcctccgca aacagccagt ctcggatctg 3252181 gagtccatcg ccatacagcg gaacaggcag gccctgcttc gcatgacgga taatcgtcgg 3252241 aatcattttt tcgctgtgct gataaggtcc gtaattgttg ctgcatcgtg taatgatggc 3252301 cggaagcttg tgggttttca cataagacaa cacgagcaaa tcagagcttg ctttgctggc 3252361 tgagtatggg ttattaggag aaagcggcgt cgtttctgta aacgcgggat catccgcttt 3252421 taaatccccg tatacctcat ctgttgaaat atgaatcagc ttcttggctt ttcctttcaa 3252481 gaccgcttcc gccaatcggt atgtccccat gacatttgtg gtgataaacg gctccgcttg 3252541 ggaaatgctt ctgtccacat gcgattctgc tgcgaagtga atgacgccat cgtaggtctc 3252601 gtcaaaagcg cggtcgatat cctcctgaac gctgatgtcc ccttttacaa agcgaaaacg 3252661 gctgttttgc tttaattttt ccatttcctc cgggtggctg gcgtacgtca gtttatctaa 3252721 aacggtaatg cgcgcatccg tttccctcag catgagcttt gtaaacgtga gcccgatgaa 3252781 gccggccccg cctgtaatta aatatgattt tgccatcact tttcgtcctg tcctttccgt 3252841 aaagcctggt gtacaagctg ggaagcgaga taaagcgatt cgtgagttcc ggcatctacc 3252901 caccagcctg ataacacatc atacgtaagc tggctgtttt cgatgtatag attattcaca 3252961 tcggtgattt ccagctcgcc gcgctttgat ggtgatattt gttcaatata tgaaaacacc 3253021 tctgcatcat acatataaat gccggtaaca caaaggttgg tcggtggctg ttcgggcttt 3253081 tcgatgatgg aacgaatccg cttgtttttc tcatcaatct cagcaatccc gaaacgttcc 3253141 gggtcatcaa cttctttcag aagcactttt gctcctttcc cctgctgttc aaagcgttct 3253201 gtataaggct ttaatgaatc ttcaaatata ttatcaccta ataataaaat gaaagactct 3253261 tttttcgtaa agcgctttgc ataagacagc ccatccgaaa tgcccgatgc tgccggctgt 3253321 acttgataag tgatagtaac gccaagctct tccccgttcc caagcagttt gtaaaattgc 3253381 ggcatatgct ccttttggct gatgagtaaa atgtctttta ttccggcttc ctgcagcttc 3253441 ataatcgacc agtatatcat cggatacggg cctacaggaa gcaaatgctt gttgacggct 3253501 ttcgttaagg gcataaggcg tgagccgttt cctccggcta aaataacacc tttcacatta 3253561 acacttcctt acatgcattt ttatatctct tgttcatata aatcttgaag aatagctgtt 3253621 acccgtataa tgcctttgcc atccacgagc ggccttcctc ccttgtgcaa agaaaggcga 3253681 agaggatagc tgctcataat gcgtgacatc tgatagatga gtgtttcatc cggtacaagc 3253741 tcacccaatc caagatcaag agcggcgcct tggtcagcaa atgttttggc tgtagccgtt 3253801 tgatgctcaa cctgagaaag aacaaggcac ggcacgccga tgcaaatggc ttcatataga 3253861 gagatgccgc cagcgacaat ggctgcgtcc gcttgtttca tcaaacctgc catatcattt 3253921 gtctgttcga tcatcttgta ctgcggcttc ttttcgatcc gccttcggac tgcctcttga 3253981 tgcggtgaag cgctccccat cacaaacatc atgtttttgt cttttatgtc ggggacttga 3254041 tcagcggcag ccagcacttt aaaaataagc tgcttcggat cacttcctcc taatgcaaca 3254101 aggatattgc ggcagtcttt cttaagtgtg taatcctctc ttgcggcctg aaaggcgggg 3254161 tgaagaataa gatagtccgg accttcatag atgcgtgtgt ttccctgaac gtacaccctg 3254221 cttctgatgt caccgtaaat tccgttaatg actgcgtcac tatattgaat cgatttaccg 3254281 tttttctctt caaaaagaac aattttcgca tctgtctccg tctttatttt ctttaacagc 3254341 tctgcaggcg cgcctagaat atcaaacaaa agcaaatcaa gcttcttgct ttttatttcc 3254401 cggagaataa attcgtgctg ctgcagctcc ggctttacga tgacctgcca atgctcttca 3254461 tgaagaaacg cttcagaatc ctgattcgta taaaacgtaa tcaagcatcg ctgtttgagc 3254521 ccctccgcaa gcctcttcat ccggacaaca tggcccattc ccttttcata gccgccgtct 3254581 gcgaagatcc caacatgcat ggctagtcag cctctcgttc ggttgccgca tcggggttcc 3254641 ggttcagaag ggtgataagc tctgaggcgg atacatcggg gcgctcgcct gctttttgat 3254701 agagggcctt tatcgattca tagtcttcct ttgtatcaat ggtcagccga tattgagggg 3254761 cgcgaaatcg ttccggcgcc tctaaaaact gaacacgata aagagctgga tgattcctta 3254821 tatataacgt gacatgctcc tgatattgat cctccaaagc ctgaatacgg ctgatgtcaa 3254881 ttaacaggtt ggcgttgacc acttcgccgc aaatccctaa tggggcattc aggatatacg 3254941 tataatccga gccttgatca aaatgcgcct gaatcattac atcgagcagc tcaggatcga 3255001 caaacggatt atcacctgtt aaccggatga tgactgacgg tttaacagct tctatgacct 3255061 tcacaaacct atcgaggaca cgttcttcgc tcccgcggaa aacacgaaag ccttgtttga 3255121 tacagtgcgc ctctaatatg tcgtcagttt ctttgtcaga cgtggcgatg acaagattat 3255181 cccgatcctt ttggtaaaac gcgctttgcc ggacacggtg aacgagaata tcaagtaaac 3255241 gattcgatcc gagcggccga agcacttttc ccggaagcct tgttgaaccc attcttgctt 3255301 gaatgataaa gagaatatca ttcatgaaac gggctgtcct tcagtaaaat gtcatcccag 3255361 acaatgcctg tgtcggctgg aatgtctctt acagcccgaa caccgctggt cagcagttca 3255421 aaaaatctcg ggtgcagccc ctgcggcttt tgtccgggcc gaagcactgc gatattgtct 3255481 tcactaaagg cttcaccttt ttgaatcgga gctgttgtaa aaatgcctct gtatgcaaag 3255541 tttctgattt ctccttcgat ggcggtcgtt gttttgtatg aactgccaag cagtttttca 3255601 gagaccggct ttgtgatccc ctgtttcagc tcagcttccg ttttcctgat gccatcgacc 3255661 atttctttca attcatccgg atttaatgca aacgagtggt cagcacccgg cagattttta 3255721 tcgatcgtaa aatgcttttc tatcagtttt gctccgagcc gaaccgcggc acacggcgct 3255781 tctgtcggat gctcgctatg atcggagaag ccgattaccg cctcaggaaa agcggcggca 3255841 agcatcggaa tgacgctgag gttgctgtac tccggcggtg ctgggtattt cgccacacaa 3255901 tgcattatgg caatttgatt gtttccctct gccctgatgg tgcgccaagc ttcgtgaaca 3255961 tcagagattt cagctccggc tgtcgagaaa atcatcggcc tgttcagccg ggcgacatat 3256021 ttaagcagcg ggagatggtt aatttcatag gatgcgattt taaaagcgct cggcgaggta 3256081 gactgaagca gatcagctga cccctcgtca cataccgtac ttaaaaagat cacctgcttt 3256141 tcgcggcagt aatccaatag cggtaaaatc cactcagcag gcatttccat agattgaacc 3256201 aaagaaaaaa tagagacgtc cttgcccgct gccgtcttgt acaaaccagg atctttctgg 3256261 tacatcctat cagcttggaa catttgaaat ttcacggcat ccgctcccgc ttccgccgcg 3256321 gcgtctatca gcgcaaaagc ctgatcaagc ttcccgtcat gattaatccc cgcctcagca 3256381 ataataaaaa caggagcgtc tttgcctaca gttttattcg cgatctgaaa cgctgccatt 3256441 atttcgcctc cttgcccggc caaatatgat aatagtaata cgattgttca gcggtgaagc 3256501 ccattcgttc ataaaggcgg atcgccctta cattgtgaag ctgcgtcccc gctgttaccg 3256561 ttctatgctt ctgggtctcc ggttgttcta tgagattcgc caataaatga aacgcaatac 3256621 gtttcccttc aaatcccggc tttacagcca tcaaatcgag aatgcactca tcatctcttg 3256681 ataagccctg aagatagccg atgacctcgc cattgtgttt agcgacaata ttgaccgccg 3256741 cccttccatt cagattgttt cgtgtccact cctgaaatat ttcgtttgct gcatcgcggc 3256801 tgagatgagg atcctgaaaa tatctgcttt ttgtaaacga gtctcgggcc agctcacata 3256861 tcgcttctgt gtctccgggc tcaggcgggc ccagttcaaa aaatggcggt gttttgtcat 3256921 aaaaagacgg aggcatcgcc agcttcagca aactcccgac aaagtaagag gatggctgct 3256981 gttgtatcac atgcgcggct ccgatatctt cagccggaac acggacaaag ataaaatccg 3257041 tttcatccat ttggcgtaca gtataaaaag cttcaaacag cctctttagc tgcccggtac 3257101 tatttgccgc aagaagtttg acgttcatga ctttcttctg aagcaccttg ctttcccaca 3257161 aagaatcttc gtaaagcaat acgccttgga gcctgctgtt ttcaaaaagg ccgagggaaa 3257221 attgatacgg aacatccaat gtaagctttc tgctttggag aaattcctca attgcctctt 3257281 tggagacatt ttcttttacc gtatacactt aatcagcccc ttttacgata tcccgcacag 3257341 cttcaatgac atcatctaca tcatcgtcag acattgatgg atagagcggg agagaaaggg 3257401 ttcgtttata gtaattcatg gcattcggaa agtccgcttc cttatatcca aattgctttt 3257461 gataatacgg atgaatgtgt actggaataa aatgaacgct agtgccgata ttgtattcat 3257521 cctttaaagc cgtaatcatt tcgctgcgcg taaccccggc ctttttttca tcaacttgca 3257581 gaacatatag atgccaggcg tgcctgccgt catcatggac aaacggcgtg atcagcccag 3257641 gaatctgctg aaaagcggtt tgatagcggc cggcaatctc ttctctccgt ttctgcatat 3257701 catccagccg tttcagctga tgaagtccga gggccgcctg caaatcaaac atattcatct 3257761 tatagccggg cgattcgact tcatagtacc agctgccatt tgaagaataa cggttccatg 3257821 cggctttact catgccgtga aggcttagca cccgtatctt atcggcaagc tcctcatcat 3257881 cagtcgtcag catgccgcct tcccctgtcg cgaggttttt ggtggcgtaa aagctgaatg 3257941 ccgttgcatc cccgatagaa ccgatcattc tttgcttata agtcgtatat accgcatgtg 3258001 ccgcatcctc cagcacgaat aaaccatgat tttgggcaac agccaatatt gcatccatat 3258061 cgcaggactg cccgccaaag tggacgggca caactgcttt cgttcgcggt gtgacggccg 3258121 cctcaagctt taccgggtca atattgagcg tgttttcgtc aatatccgca aacacaggcg 3258181 tcgctcccgt atgaataatc gtattggcgg tcgagctgaa cgtaagcgga gaggtaatga 3258241 cctcgtcccc gggcccaatc ccttttgctt tcaaagccaa aaataaagct gcggtacatg 3258301 aattcaccgc cacggcgtgc ttcgccccga caaacgcggc aaactctttt tcaaactgct 3258361 gaaccttcgg gcctttagag agccatcccg attcaagcgt ttctgtaacc tcctgaattt 3258421 cttccttacc gattaacggc aatgagtaag ggagaaaatg atttctcttt tgcaccattt 3258481 ctttgcgctc ctatcatttt attcagtatc ttcccgcctg taatcaaccc ctgttttggc 3258541 tttcagttcc gcaaataaag catttgttga ttctgccacc ggataattag ccgctatgaa 3258601 tgccaggcgc gcctcttctg ctttttgatg cacgtcggga cttcgaagaa cctcaaccaa 3258661 ggtgtgcgcc agttcatccg gctggtcaaa cataaaatcg ccaagagact cataatacgg 3258721 atacgagcga tttccggacg attttcctat cagcacaggc ttttgaaaca gcatggcttc 3258781 aagaccgact gtcgaggttt gcgtcactgc ggcatcaaca tacggcagca aatcataaag 3258841 ctccagctcc tttttgatga ctctgcatgc ttgatgtttt ttcgccgcct cgtgatacag 3258901 atcaagcttg ttttttccga tttcccacgg gtggggtttg ataatgattt gcagctgctt 3258961 ctgatcagaa agcccctgca gcacaccgga ataaaagtct tctgaaaagg gctgagtggc 3259021 aatgagcaca atttttttag tcggctgaaa agcaagtttt cgatagaata tggacatatc 3259081 cataggcgtt ctgttaaaaa tctgatcgaa gcggggatgt cccgttacga gaatctgctc 3259141 gggtttacag ccttttcgta tgaaccactc tgcttcatac gcaccaaaaa cagcttgata 3259201 ggttgtaaaa acaggaatga aggcttcatc tcccatcaat gcgccatgct gaagacaaat 3259261 gctgacggcc ccttttcttt gacacatgag agcgagcacc ctgctgtaaa tgtcttctgc 3259321 cgttccgaca ataacagctg aaatcttttc ctgttcaaac agcgcatcaa ctgtatcaat 3259381 ggcctctata aataaaggaa tatctttgaa aagccggtcg cgaaacgctt gatcaccaaa 3259441 tgccgggtga tcatcataag gggcgagaag cgaacaggct gtttcgagat actgcttcga 3259501 atcgcctttt tggcatgaat ccgcaatctc ccgcttgcta attacaggca gatcacaata 3259561 atgcggcaaa ctccatctgg ccaaaacagc cgttttttca ggatcaaatt gatagtaatt 3259621 ttcgtttgaa aaacgcaggt aatcaaagtg caaaatgact ttccctttaa caggttcgtc 3259681 atttgtttta acgatgtttt ggattctttc ttcaaaaaac ggctgaatct gtccctcatc 3259741 gatatgctga tccaccgatc cgaataattc cggttcttct tccatcatca ccctcagttc 3259801 agggctgatg tattgataaa aattactgat aagcccaagc ggaatccctt tgtagcgaag 3259861 tttgtcaaaa agctccacgt acttccggta cagcacccaa taattgctta aataggccga 3259921 caagctctca ccccattcca agctttttta atgattcacg cagctctcgg caatttcgct 3259981 gcggaggaag gttcctgaca aattcatttt tttctaattc aaacagctga aagtgaatcg 3260041 attggtcggt aatataattc aggtccagct cctcatccag tgggtaaaac ggataaaaat 3260101 gattgactct ccaaaagaac cgggcatctc ctatacggta aaacgccggg ctttcatccc 3260161 aataggagcc aaacttctcc tttaccttct caagcaccga atacctgtgc atcaccgagc 3260221 aatgatcaat tgcgcacggc gcgttccatg tcacttgagc ggcaggcctg acagtttctt 3260281 ttacaatgtc acgattctcg tttaaatgat aggttttgga ggctgagtaa atcacagcct 3260341 tttcaggatg ggtatcgagc tcccgcacca ttttcaggag gcggtccggc atatagatgt 3260401 tgtcatccgt cgcataggtg atatattcac cctccgccat ctcaatcgcc tgattgatca 3260461 gtgccgcgta tctcgttttt tctgttcttt ccttcactcc agatatatcg ctttgataaa 3260521 aacgcactcg gttatcattc aaaaaaggac ggattacatt cagcgtctct tcattggagt 3260581 tgtcatccat aataaacaat tcaaaatctg aaaacgtttg tgagagtatg ctagaaatgg 3260641 actttgccac ataatcgctt ttgttatagc tcgtcataat gactgatact ttaggcaaat 3260701 cctacacctc cttcttggaa cttcacacct gaaactatcg ttatcttatg ttgcttatgc 3260761 tcaagttgcg ctagggatac aaaccaatat gcgaaaagtt tgtgtatgtt tctgaaaaac 3260821 agcggctgcc cagagcgaaa tctgatcggt ccgctgttct ttttcagcat aatccaagca 3260881 tcagcctcat aaggtgaaag agataaaaat cgcaccagcg actaagatcg ttttccatcg 3260941 gaggtgagtc atcgcggagc gttcacctat acatccagaa catgttttga atggttttca 3261001 taaaaaggag gaacgatatg aaaccgaaaa aaaatcaata tcagcaaatg caggcatttg 3261061 ataatatgca ggggtatcag cctcagtttg gcgccaaccc gtacccgcag caaggccaag 3261121 gctcacaaat gcagacaatg gggatgcagc caatgatgcc aatgcagcag ggacagcaag 3261181 gacaacaagg acagcaggga tttggattcc cgggccagca gcagggcggc ggttttcaaa 3261241 ttccatcggg gcctacaccg tcaggaccgg gccaaagcgt tcccggcatg ctgcctgttg 3261301 aggaatctta catcgagaat attttgcgcc tgaatcgggg aaaaacggcc accatttata 3261361 tgacatttga aaacagcaag gaatggggct cgaagatttt tcgcggcgtc atcgaagctg 3261421 cgggccggga tcacattatt atcagcgacc cgaaatcagg aacacgctac ctgctcctga 3261481 caatctacct cgattacatt acatttgatg aagaaattgc ttatacgtat ccatattcca 3261541 tggcgtccta ttcgccaaga taagaaaaaa gccaatcact catatgatga ggattggctt 3261601 ttttgtttat agatatttga cggctgcgac aacgatcata atccaagaaa taataaacgc 3261661 cacaccgccg agcggggtga tcgctccaag aatggagatt tgcgtcacac ttagaatata 3261721 taagcttccg gaaaacagca caattcccgc aaacatcagc cagccggctg tcgtgacact 3261781 gcctatgccg gataatttat cagccagaaa cgcgacaacg aataacccaa gggcgtgata 3261841 catatgatac tgcacgcctg tgtgccaaac ctgaagatac ttatcaggta ttttcccttc 3261901 taatccgtga gcgccgaatg ctccgagtcc cacggcaagc agggcgttaa tggcccctaa 3261961 tatgataaaa actttcatct atctctcccg ccttttcgtt aaactcatat catttatctt 3262021 atcgcacctg caccaaaatt caatgtttgt tctccgttga cacgagattg tcggattttc 3262081 tcctgcgcca aagctggaac tggtcagctg ctattgcagc aagcgtccct aatacgagcc 3262141 cgttgcttaa tagagaaata aataccggat gcaatccctt taacgcagtt tcaggaacaa 3262201 acatgatacc gacccctgtc agcagtgaga taccgatgat agacctcacc ctttttgatt 3262261 cttctttctc atatgaatca aattcggcaa aggccagacc gcccattgcg gagaacacaa 3262321 caaaattcac cgcaaatcca acgggtgacg gcaggctcgc aaacgtattc ataaaaaacg 3262381 ggatcacgct gatcacgata accagaatac tgccgagcat aaacggtttt ttagaaggca 3262441 tcttggtcgt ttcaataaaa cctgcggctc ccgaaatcgg aacaggcgca atagctcccg 3262501 tcaaaccgct aagcagatgg ctgaatgaag ctgcaaaacc ggcatggcgt tcatgatgct 3262561 ttccatcagg ctgtttgctg aattttttca tggcgatgtc cacgaccttc atgctcgcca 3262621 gcatattcac gatcagcaag atggtaataa aaatagaagt gatgatcagg ccgctgttaa 3262681 ataacggggt cccaaaagga aacagggaag gcagctgaaa cagccggtcc ggcatttcaa 3262741 tcggctttgc ggctccggca gccgcaaaca gcacccaccc gccgaacaag gctaataaaa 3262801 tagaatattg cttaaaaaac atgatgttcg aatttgtcat tataaaagcg gcagcgatca 3262861 caacaagcgc caggccaaat acaagaccgt ccaccccgtc ctgtcgataa ccgattccga 3262921 gaattccttt tataatgggc tgactcagct gcatgacaag aagcaataaa tagacgcccg 3262981 ttacaaccgg agtaaacaat tttgcaagtc tgtcaatgac cttgaaaaca cttaacaaaa 3263041 agaaacatac agcgcttaca agaagagctc cctgcaaacc ccgcagtgtg tctccatatg 3263101 tcgcaaacac agttcccgtc agccctgcgt aaatcgtata cactccccac cacaagccgg 3263161 ctgggctttc attgatcggc agtctgtggc ctttcaaaca ctgaatgacg gcggcaattc 3263221 ccagtacaaa aaaagtgctt tgaatcaatc ttgcagaatc tgagtgatcc agatgaaacg 3263281 actgggcaac cgccaccgga acaacaatcg ccgcagcaat aataaacgct gtccattgca 3263341 gcgcgccaag aaccaatttc acgtaagctc aacctctctc tttaaaaatc aaataaagac 3263401 tctccgtttc catcctcttc ctgcttctct ttttcttgct ttcgatattt gtttaatccc 3263461 gcgctcccca tcattttttc catcatcagc tggtctgtcg atggcggcgc ggcgggactt 3263521 ggcgtaacgc tcggctgtat gcggggcgcg ctcgcgttct ccggctgatc aagcacgaca 3263581 tcacacagag aacggacaac cgctacataa cgcttcagct cctcatcccg ttcagccgtt 3263641 tttgcttttt ttagctcttc ttccatcttt tgaatcaaag cagatatatg aatgttcatg 3263701 aagcaccctc caaaaaaata aatgttgtct tcctgcattt tatcaaattc ctgctgaaaa 3263761 cgcagatatg agtttgttat tttttctgac aaaccttgcg cgattgacaa gcagaagaga 3263821 tttttcacat aataaatcac cataccttac aaaaaggaga aacggaatga acagcatccc 3263881 ctctatcatc agcaagcata aagcctattt tgcggcggga catacgagac cgcttgaatc 3263941 gagactgaac attttgcgaa agctgaaaca agccgtcaga actcatgaag ccgatctcat 3264001 agccgctctc taccaggatc tccataaatc cgagcaagaa gcatactcaa cagaaatcgg 3264061 aatcgtcttg gaggaaatca gctttgtcat gaaacggctg agaaaatggt ccaagccgaa 3264121 acgagtcaaa acgccgttga ctcatctagg ctccaaaagc atcatcatcc ctgagccgta 3264181 tggaaccgtt ttggtgattg cgccttggaa ctatcccttg cagctggcgc tttctccgtt 3264241 gattggcgcc attgcggcgg ggaacacggt cgttctcaag ccatcagaat atacgccggc 3264301 tgtttctgct attctttcca aactcatcag cagcgttttt ccaactgatt atgtcgctat 3264361 ggcagaaggc gggcccgatg tcagcacagc attattacag cagccctttg actacatttt 3264421 ctttaccggc agtgtagctg taggaaaaat cgtcatggag gccgccgcca aacaattaat 3264481 tcccgtaacc ttggagctcg gcggcaaaag tccctgcatc gtccataaag atgctgacat 3264541 tcagcttgcc gccaaacgca tcgtcttcgg gaaatttaca aatgcgggac aaacctgcat 3264601 cgcaccggat tatttatttg tccacgagga catcaaaacg aagctcacag aagaaatgaa 3264661 gcgtgcgatc agagaatttt acggccctca gccggaacgg aatccacagt acggcaaaat 3264721 cgtcagtgag cgccactatc agcggctgct cagctttctg aatgatggca tcccgctcac 3264781 aggcggacaa tctgatccca atcatcacaa aattgcgccg accattctcg aacaagtgag 3264841 agatgactct ccagtgatgc aggaggagat tttcgggccg attcttccgc tctttacata 3264901 ccgcaatatc ggggaagtca ttgagaaagt ccaatcgcgc cctaagccgc tcgccctgta 3264961 tctcttcacc acaaacaaag aaattgagcg cgctgtttta ggaaatctgt cgtttggcgg 3265021 gggctgtgtc aatgatacgt taatgcatgt tgcgacgccg tatttgccat tcggcggcgt 3265081 cggggaaagc ggcatcggca gctatcacgg gtttgacagt tttaacacat tcacgcacaa 3265141 aaaaagcgtc gtcaaacaaa cgaaccgttt cgacttcgca tttcgttatc cttcctccaa 3265201 aaacgggctg cgaatgattc gaaaaatact caaataaaaa agcgcagatc acctgcgctt 3265261 tttacaaatc cttaatacac caatcaatcg gcgcctctcc cattttctcc aaataggcat 3265321 tcgcccggga aaacggtctg ctcccgaaaa atccgtttct cgcagaaaac gggctgggat 3265381 gcgtcgattc aatgataaaa tgcttggagg tgtcgatccg ttcttttttc atttgagcat 3265441 gccgtcccca caaaataaag ataaccggcc gctctctttc actcagcacg tcaataattc 3265501 ggtccgtcag tcgctcccag ccttttccct tatgggaatt cgcctgtccg cgccttactg 3265561 tcagcacagt attcagcaaa agaacgcctt gctttgccca gctcacaagc gacccgtgat 3265621 tcgggatgct gcacccgatg tcctgctgca gctcaagaaa gatatttttt aacgaaggcg 3265681 gctgctttac accgggcttg acagagaagc ttaaaccttg agcctgtccc ggcccgtgat 3265741 acggatcttg acccaaaatg acgaccttga catcatcata tgatgtataa tgcagcgcgt 3265801 tgaaaatatc ccggctgtcc ggataaatcg tttgctccgc gtattccctc ttcagcatct 3265861 ctctgagctc ttgataatac ggtttctcaa actcttcctt tagctgattc caccagctgt 3265921 cttgtaaaag ctgtttcaag attcaggcct ccttacgaac gatgaagtct ggaatagaca 3265981 ggctcgccat cccaaaccat ttcacttttt gcttcccgcc tcttcatctc aggctcttca 3266041 agcaggacgg caaagttttt cgtcggcagc tccccgagtc cgtgcttttc acttaaacga 3266101 tccaaatatt gcttccgctt ggcgccaagg tcagcagact gattgtctcc cgcgtcactg 3266161 aaggcataaa tcacgctggc gcaagggaca cgcttcaccc ggtaatcctt ggccgcgcgc 3266221 aaataaaaat cccagtccca gtaattgtgc acatcagcat cgaaataccc gatttcatca 3266281 tgcagaaaac gtctgtacat gctgcccgac ggcacgtatg tagaaaacac tctcatatcc 3266341 tcatagtcag cggtataagc aaacaatttc cgtgacactg gataccttgt tccgtttttc 3266401 tcttcaaacg aaactatttc cgcatcagaa tgaacgaagt ctgccgtttc tatttccttt 3266461 gccattttct cgatatgccc tggcgtaaag aaatcatcgt catcacacag cataatgcaa 3266521 tccccagacg cctcttttac accggcattt ctcgcagcca catgccccga gttcttttct 3266581 aaattgatga cagcaatcgg cagctccgga taaagtgctt tgaccggcac gaccgattcc 3266641 ccggcatcat tcacaataat aatttcatac ggcatcaagg tctggcggga aatcgactcc 3266701 aaaagctcac acaaagccgg aatccgatta taggtcacaa ttacgataga aatcttcatg 3266761 atgctctcct tctcattttc atagtcatgt actattaaaa catatattgg acgggagatc 3266821 agtgggaata tcctactgaa acggcatact acaatgatag aaacagcaaa gtggctccga 3266881 tcagaagcac catgatcagc atcagatctc caaagacatg aaagatatct ttcatgcgga 3266941 cgccattcgg aaggataaga cgccacagct tagattgata gaccggcagc agcaccagtg 3267001 cataagaaag acacaaaaat gtaaaagccg gcggcacaaa agcacagcct gcatcgtccc 3267061 aattcatcat gatgtctttc atactagatc catccaataa aaacaaagat atcatgaggg 3267121 ctagcaacac aaaggacccc aattgaacct caaacaggcg cattttctgg ttatatgcaa 3267181 atcggaccgc ccaaaaccag acataagcat atgaacatag cagcgtaaga atggcacctg 3267241 ctgtaaagac gacatcaggc agccgatcaa gcagaaaaac aaaaggcaag ctggctgcca 3267301 tagccaagag catgcagcca ccagtaaaca aaaatactgc cccatgagct acaaaaccat 3267361 ataaacaaga gctaatcctc acgacataca cctcctttac atagaaattc tatgtatata 3267421 cctaaaaaat cagacaagct gacgcctgcc aatataacag cccattcggc caaataacgg 3267481 aaataacagc gttgcaaaag cacaagttcc aacaaaccaa ggtgtcaaca aggattgaaa 3267541 cagcgcagca ggaattacat tgaatagaaa aacaagcata aaaatgacgt ttggcaccat 3267601 tgagatcaga atcgtatgta gaacaagctt ttctccgcgt tttccaaact ccttcacgcc 3267661 ttgataccca atcagcaccc agtagatcat atatgcagct aagatcagcc aaacagaaac 3267721 agaaatgcct ttccatactg cttgaacaaa cggtgattca agccatacat gcattattgt 3267781 aatcgcaatg ccgacagcga atagggcact gttacagaaa agatggaaca tcaaaaacgc 3267841 acgaaacgtt actggctgta ttttcttaaa cgaagaaaca atgtcagttg gtgttccaaa 3267901 cgcctgcaat aaagtctgca tagcttcctc ctcactcttt ccttcctgaa aagagcgaaa 3267961 cagatgatgt tcaatatggc tctcaatctc ttctatcatc gcctcaccct caggaagccc 3268021 tttaagcccg cttttgattt cggatacata tgtttcttta tccattttgt ccgctccact 3268081 tcagtattcg gtccatcatg gctgaaaata cgctccattc cttcgtgcgt tccgccagca 3268141 cttctttgcc ctcgtctgta atccggtaat atttgcggtc cggtcctttc tcctgcttct 3268201 cccagtagga agaaatatac ccttggcgtt caagcttgtg aagagaagga tacaaggtcc 3268261 cttctttcat ctgcagttca tttccgctgc ggcttcccat ttcttttaca agctcatagc 3268321 cgtacatcgg ccgctcgttc agaagcgtca ataccaatat aaccgtgctt cccttaacca 3268381 gctcacgatt taacatctca aaacccctac ctagttttct tatgtagcat tttacgaaag 3268441 cccgttgaga ttgtcaaatg attcctatag atcttctata ttgtgataca gagaaaatct 3268501 aactataatg aaagacaaaa catgatggag gttcaagaca tgtctatgca taaagcactc 3268561 accattgccg gctcagattc cagcggcggt gctgggattc aagctgattt aaaaacattt 3268621 caagaaaaaa acgtatacgg gatgaccgcc ttaacggtga tcgttgcgat ggacccaaac 3268681 aacagctgga accatcaggt attcccgatc gatactgata caatccgcgc ccagcttgca 3268741 acaattacgg acggcatcgg cgtggacgcc atgaaaacag gaatgctgcc aaccgttgac 3268801 attatcgagc ttgcggcaaa aacgatcaaa gaaaaacaat taaaaaatgt ggtaattgac 3268861 ccggttatgg tttgcaaagg tgctaatgaa gtcctttatc cggagcacgc ccaagccctg 3268921 cgtgagcaat tggctccgct agccactgtc attacgccaa acttgtttga agccagccag 3268981 ctcagcggca tggatgaact aaaaacagtt gacgatatga tcgaagccgc gaaaaaaatt 3269041 cacgcactcg gcgctcaata tgtcgtcatt acaggcggag gcaaactcaa acacgagaaa 3269101 gccgttgatg ttctctatga cggagaaaca gcggaagtcc ttgaaagcga aatgatcgat 3269161 acgccttata cacatggcgc aggctgtaca ttctcagcag ccgtgacagc ggagcttgcc 3269221 aaaggtgcgg aagtcaaaga agccatttac gcagcgaaag aattcatcac agcggccatt 3269281 aaagaatcct tcccgctaaa ccagtatgtt ggtcctacga agcattctgc actgcgcctg 3269341 aatcaacaat cataaaaaaa ggggctgcct tacagagagg cagccctttt taaatcaccg 3269401 aagacttttc acagaaaaaa ctgccgatcc catcggcagc ctgtttattt gatttttaaa 3269461 ttgtttgcag atttcctcaa aaatgtttct atcgactgaa caaaaagtgc atattccttc 3269521 atttgttcat atgcccgcgt gagaatttcc gccgtttcac tgtgcggcgt tgttccgcca 3269581 agcatttttt tcagctgaag cagcacatcc ttatattctt ctcgcttatc ttcaacttgg 3269641 ttagcagcct tttccaaaca ttccggtgtt atcttctgtt catgtatatt caagaaaaca 3269701 actcctttta cagaaaaaaa tagtaggtta tcgttgaaga atagcacaga tggctcagat 3269761 ttcacataag aaaatagaag gattttctac ataagtgtcc aaattccgac attcatttca 3269821 gatttcccgg tcgcactggc tgttacttca tgatttcccg ggaaaggaaa atatcttgca 3269881 ctcaagacct cttctccgtt attgataaag atttccacag atgacgcgtc gagaaacatg 3269941 tgtacggtat gcaaatcctt gatgcggcaa tgtctcgctt ctgttctttt tccgtcaaag 3270001 ctctttcgtt ccagcgtaac aatcccctcg tctttatgga aggaaaacgt agccgttccg 3270061 cggatactga ttgaaaagcc agactccgta tgaatgtctt ccagtagaat ctcagttctt 3270121 tcaggttttt ccactggaag cgcaccagat gatccatgca tgttgatgtg tatttttttc 3270181 tcatttctgc gcatggcttt tagctcaggc agcggctgct gaatcagctt ctgtcctgaa 3270241 agcgtcagct gtctcggcag cgtcatgcag tgaatccagt ggcagtcaat ggtcggatgg 3270301 gacccttcat cctgatcagg caccgccatc catgcaaata aaatccgcct tccctgatcg 3270361 tcttcaagtg tttgcggcgc gtaaaaatca aaaccttgat caagctccgt aaattcacca 3270421 tgcttcagtt caggcttgtt ataatcgagg cggccgacaa aataacctga ttgatatacg 3270481 ttctgataac ggaaaccgtc agcctcaagc ccttgaggcg aaacaatcag cacatccgat 3270541 ccttgaaggg aaaacaaatc agggcattcc cacatgtatc caaaatcgtc cagcccgttg 3270601 aagcccgcgc cggttatcgg gccaagaaat ctccactctg tcaggttatc agaagcaaac 3270661 aacacagcct gccctttcaa attctctgtt tgcgcaccaa tcaccatata ccatgtgcct 3270721 tcatgctccc ataccttcgg atcgcgaaaa tgcgccgtat atccttccgg aaggcgggcg 3270781 acgacaccct ttttctcaaa ggacagcccg tcgtcagaaa cagcaaggca ttgatacgtt 3270841 tcccgatttc catcctgatc cctgacattt cctgtgtaaa aaagatagag ccgatcgtct 3270901 ttcgtgacag cgctgcccga gtagcagccg tttttatcaa accaatcact cggagccagc 3270961 gcaatctctt cccgcttcca attcacaaca tcctgtgtcg tataatgccc ccaaaatttt 3271021 gcgccgtgcc ccgtctgaaa cggctgccac tgaaagaata catgatagct gcccttccaa 3271081 taaatcacgc cattcgggtc attcagcagc ccaaccggcg gcatgatatg aaaatgctgg 3271141 cggtgcggat cgctgttagc gatgggctct tttttctcca cttcttcata agcccggcga 3271201 cgaagctcct ggtcatgtgc tgtcattttt tcctctcctc atcctcatta atcttcatga 3271261 caaatgctgc aatgaacgct gacactgccg caatcgccat gccaatcaga tagtgaatca 3271321 agttgctgaa gccaaacgga gccgcaatgg cgatcatcgg aattcccgtt aacccgtaag 3271381 cgtttgcagc tacatgtgta aagacgacat atgccccacc caatgcgcct ccgatcatcg 3271441 cggcgataaa cggttttcgg tagcgcagat tgactccgaa tatgacgggc tcagtaatgc 3271501 cgagaaaagc ggaaaatgct gccggaagcg cgatttcttt tgtctttgcc tttttcgcca 3271561 taaagaagac ggcaagacct gccccgccct gtgcgacatt cgccattgac cagatcggca 3271621 gcaagtagtt tttgcctata tctgcaatta gccctgcctc aatcgcatgg aagctgtgat 3271681 gaacgcctgt cagcacgatg agtgaatacg tgcccccgaa aatcagacct gcgacaaaac 3271741 cggcatggtc atatacataa gttaaagcaa ccgtaatgcc ggagccaagc gctctgccta 3271801 gagggccaat cgcgataaaa gcaacaaacc cggtgacaat cacagtaaca aatggtgtaa 3271861 caagcaaatc caccgcatgt ggaaccactt ttctcgtcca tttctctacc ttgctcatca 3271921 catacaccgc aagcaggaca gggataacag ttccctggta gccgagaaga gcgatatcaa 3271981 atccgaaaag atgcatgtaa tcaggtgtcg cttccgccaa tccccatgga tttaaaagat 3272041 tcggatgaat catgattccc ccgatgaccg ctcccaagta tggattgctg ccaaactctt 3272101 ttgaagcgct gaccccgatt agaatcggca agaaaatgaa tgctgcactt gaaaacatat 3272161 caagcagctg caaaagcgca gaatccttgc tcatccaatg aaacgcattg atcataccca 3272221 gcaatcccat taataggccg ctggctacaa tagctgggat gattggaaca aaaatattag 3272281 aaagcgtttt cgcaaatctc gcagcgggat tcagcttttc ttttgccgca tcctgatgat 3272341 tgacgtgttc ttcacgctcg atatcagctt ctttagaaaa ggcatcgaat actttattca 3272401 caaggcctgt tccgaaaatg atctggtact ggccagagct gctgaaagcc cctttaacgc 3272461 catcaagctc ttctacttgt gcttgatcta tctttgattc atctttcatc actaaacgca 3272521 gtcttgttgc acaatgagcc gcgctgataa tattttcttt ccctccgaga agctcaatga 3272581 ggcgttttgc agtctctttg taatccatct atttctcccc cttttattta aacaaaaaag 3272641 acctaaaatt cgccaacgaa taaaggacac agcgatcctt tttcatttac gcaaatttta 3272701 ggtcttgcct gctttaccag tcacaatccc gcttattcag attaagaata cgctttcatc 3272761 ataaatcatg atagcgtttt cgtcaactat ttttttagtt aaatagtttg atataacatg 3272821 tagacaaaaa ttcgtaaaaa ttaattgtga aatacttcac aatatcgtgc tatactatgc 3272881 tcaatcatga aagaaagcag gaaaagacaa tggaaactca agcattacaa aaggttgaac 3272941 agtatgcttt gaaaaaacaa aacatattcg cttcaagcaa aatccgttat gtgcttcggt 3273001 ccattttggc cagtatattt attggttttg gcattacagc cgcaagcaaa acaggcagct 3273061 atttctttat ggctgattct ccgtttgcct ttccggcagc cgctgtcact ttcggggccg 3273121 ctattctgat gattgcttac ggaggcggag atttatttac cggcaacacc ttttatttca 3273181 cctataccgc gctccggaaa aaaatcagct ggcgcgacac cctatacttg tggatgtcaa 3273241 gctatgccgg caatttaatc ggcgccattc tgtttgccat cctgatcagc gcgacgggac 3273301 tttttgagga gccttctgtt cattcctttt tgattcattt ggcagagcac aaaatggagc 3273361 cgccggcttc cgaattgttt ttcagaggaa tgctgtgcaa ttggcttgtg tgcctcgcct 3273421 ttttcattcc aatgtctctc aaaggggaag gagcaaagct ttttaccatg atgcttttcg 3273481 ttttctgctt ctttatttcc ggctttgaac acagcattgc caatatgtgc acattcgcca 3273541 tctcgctttt gatcgagcac cctgatacag tgacactgat gggagcagtc agaaacttaa 3273601 tccccgttac gctcggcaat ctgaccgcgg gaatagttat gatgggctgg atgtactaca 3273661 cactgaatcc tgatcaataa aaaaacttcc agagatcact ccctgcaagt caaagcggtt 3273721 attccgagag atcttgaaga cgctggacat gcagcgtgat atagccggcc tcggattccg 3273781 gcaaatgtaa ttgatattca tttttcaaaa actccgccag ctccagcgca cattgatagg 3273841 cgaatgaata ctttttttgg atgaaataaa gcatctcctc gtccatacga tggagcgctt 3273901 catttgattc caaccggctg accgcgtatc gcaaatgcgt gacaaggcgt tgataggaaa 3273961 tgctgttttc atccaccttt cgattaaagt attgttttat tttctctatc atttctttga 3274021 tcatggtcgt atgcttcagc gctgaataca tgctctccgc atccatcttc gccgtatgga 3274081 tgtgaagggc aatataaccc gcttcatctt caggcagaga cacgcccaat gtctctttta 3274141 catgtccgat cgcccacagg ccgatctcat attctttttt atagagcgcc tttatctcat 3274201 gcagcaattt attctgcaca agcagcccat tttgaatcct ttcgatcgca aaggacaaat 3274261 ggtcggaaag cgcgatatga atgtgatcgc tcagcggcgc cgcgagctct ccttccgcat 3274321 agctgatgat atcctcagct atttctatat gctcctccgg cagtgtttgc aggatttgtt 3274381 tgaacttttc attctcgtcg cgcacgacaa agatcttttc cactttattc atagggatga 3274441 gatcattttt ctttttttga aaagcgattc ccggtcccat cacgattttt tcctgatcat 3274501 cctcttttat taaagccgca ttgttgttta atactttata gattttcaag aggttatctc 3274561 tcccgccaat ttgcttttga ctgggatttt acctcctttt gaccgccatg taaagatgcg 3274621 ggcccgctct ctcctgcttt ggcgattcct tgaaggcttg caaacatctt cttttataaa 3274681 gcgcggcggc tttcgctttc tgcttttctt cctcattcac agccatccgc cattcataaa 3274741 acgaaacgag tcctgcggcc tgcacagccg cctttctttg gtatgtacgc tgagccgaat 3274801 agaccgcggc agccgcagtt tttctgtccg gcgtcaccca gttcatcaaa aagaccatcc 3274861 acacccgtaa agatacaagc aaacgtttca tagaaaaaca tccctccgct tctttttggc 3274921 aggcagcctt tttagcagcc cgttttctca gccgcagccc gcaagaaaag acggccgatt 3274981 tcttttctcg caaactagcg gctctagcaa aactcatgac tctatgatag accgtggaaa 3275041 gagaattctt tgtcacaata tgagtgaaaa aaccaactag tttttagaag ttttgttgaa 3275101 agctgaaaga attgaaatga aaattggaga accgctttga aaactttata cacaagttat 3275161 cccaaagata agaacaactt aatcacaaga gatatccaca tgtccacaaa ctctatctat 3275221 attttgtata cgaacgtata ttcctaacta tatatataca caggtttatt cacttataca 3275281 cagggttctg tgtataactc cttcgttata cacaaacaaa atccaataaa tggtccaaat 3275341 gacacaagga tttttttgaa ttttcaagaa atatatacta gatctttcac attttttcta 3275401 aatacaaagg gggaaacaca ttgaaaaagg ggatcagtca gcaaacgcct cctgcaataa 3275461 gcgatacgat cggagcttat cttcaaaatg atgcgtgatg gtcaccacca tgatttcctc 3275521 tgtttcatac gcgttactca aagctaacag ccgctcctta acctgttctt tcgtaccaac 3275581 aatcattcga tttcgattat cagcaattcg tctctgttca taaggagaat acgtattttt 3275641 ccgaacagct tcatacgaag gaactccctc taaaggaata ccctgctctc ccgccaaaag 3275701 tgtaaaatca agcacagccc caagctcctc tgccttctcc tccgtgtcag cacaaagaac 3275761 aaaaacagca actgccgctc gaggcgtatc tcctaacaca gacggtttga atcgcctctt 3275821 atactgtctg acagtaccct ctccgccctc tccattgata aaatgggcaa acatatagcc 3275881 agcgccagat tcagctgcga gcagcgcgct ttctccagat gagccgagca gccacacatc 3275941 cggagccgtt gaaatatgcg gcgcagcggt cagattcgga aaacggtgtt tgtcatccgc 3276001 caaatcatgc aaatacatgg tcagctcctt aatttgctgc ggatactgat cagcattgcg 3276061 cttaccaccg tcattcagcg cccatgatgc aatcggcatt ccccccggtg ctctgccaag 3276121 ccccaggtca attcttcctg gtgtcagccc ctccagaaca cgaaagtttt cagctacttt 3276181 ataagcactg taatgcggca gcatgactcc tcctgatcca acacgaattc gctttgtttt 3276241 cgctgctata tgactgatta gcacctcagg actggaccct gccagccgtt ttgaaaagtg 3276301 atgctcagaa acccaaaatc tcttatatcc aaggtcctca gcagcttggg caagcgcaac 3276361 ggtttgctgt aaggccgttt ctgcattgct gccctctgat actggagatt gatctaatat 3276421 acttaatgaa accatcccta ccacctcatc ctcatcgtat cactgatccc ctattttttc 3276481 tccaaagccg ctcacactgc ttatcagtgt cccctatcat tcgccattta tttgtgaaag 3276541 catgtcccta tttgtcggaa tatgttacac gtgaaacata aaaacccctc cagacggaga 3276601 ggtttgcttt agtttttatt aaagcccttt tctttcacgt agtcatttaa atacgtacgc 3276661 ggcttttgct tcataaagtt cagtatttga tcggaccacg tttcttcccg cttcccgttt 3276721 gttctttctc tatagtaatc agaaatggtt ttgtcatacg tattcatagt atgacggaaa 3276781 tcgtctgtgt tcacattata cgtattttca tgataaacgg cctgctttgg caatctcggt 3276841 tttttgccgg aaaggttcgc aggatggcct actgccagtc cgaaaagcgg gagcacatgg 3276901 tcaggcgttt gcagcacctc tgtcaccttg tccaattcat tccgaatgcc gccgatatag 3276961 caaatgccaa gccccatgga ttcagcggca atgctcatat tttgcgctgc cagcgccgca 3277021 tcaatcaagc taaccataaa catttctgta ttctcgagca gctcagaaat atgttcacct 3277081 ttttcctcag ccagttgttg atggcggtac aaatccgcac aaaatacaaa aaagtgtccg 3277141 ttcttctcaa cgtaaggctg attcccagca agcacggaca gctcacgttt tttctcagga 3277201 tcagaaaccc cgataatcga atatgcctgc acatagctgg atgtagacgc agcctgcgca 3277261 cttttcacta atgtatcaat ttcttcagct gtcaaaagct gatcagtaaa agaccggatt 3277321 gaccgatgat tcaaaatggt ttcgattgtg ttattcatca caaaaacctc cttatcactt 3277381 tttatcatat ccgaaaaaaa gtgatctcaa aagtgaaatg ctctgcacaa aaaaagacag 3277441 cctctgtaaa ggctgtctgc atatcaagaa ttaaaaagat aacttctgta tttcgtcagc 3277501 tgcacacttg cattatatac aatcccaaat ccgattaacg tggaaagtgt cgagcttccc 3277561 ccatagctga caaacagcag cggaatcccg gtaacaggca taatgccaat gttcattccg 3277621 atattctgga atgtgtggat cacaattaac gccgtatagc caacgcaaaa gaaagaagcg 3277681 aaacggttaa acggatgtat tttgtctatc agaacaacaa gcctgtagat taaaaagaag 3277741 aacatgatga caacaattgc acagcctata aagccaaatg actcacctat tatagaaaag 3277801 ataaagtcag tcgtactctc tggaacataa accttcaaat tagaaatacc attacctaaa 3277861 ataccaccag atcctattgc catgatggcc tggtcaactt gccagctgtc atttgaatct 3277921 tcctgtgtct catttgaagc agacacccaa gaagtgaccc gcttaatttg ataatcctgt 3277981 attccaactg atttagcaac gtcaggaaag tttatcatta ctaataaaat taatgaaatg 3278041 agtaagatac ctgaaccagc tatgatcgca atcaatttcc aatttatccc tgacataaaa 3278101 accattacaa gaacgataaa catacatatt cccgcagtcc cagcatcctg catcaggata 3278161 agacctacag gaataactgc gacacccgca atctttaata acaagtggat atcatcccta 3278221 agcgtccgaa ctcctttagg atttgctttt ccaataactg aagcaagcat cataatcaaa 3278281 ccaaccttca taaactctga cggctgtatt gttattctac cgatcctaaa ccaacttttt 3278341 gcccctttaa taacaggtgc aatagactcg ggactgattt taagaataat caaagataaa 3278401 ataccaatga taaaaatata taaacttaac ttttcaagct gttctaaatc aaagtacaaa 3278461 agaactgtaa tggctacagc ccccaaaaga taaaacacaa tttgctgaat ccaatccgtg 3278521 ttcccatact gcccaaactg accggcagca tatattgata ctacgcttat aataaaaaac 3278581 acaccaaata taaaaatcaa atccccctgg taaaaggggc tttgctgttt cttatatcga 3278641 ctcattctat cccgccttac attttcatcg gaaaatcact aatgtttatt atacatgaac 3278701 cacgttcaag atgacacgtg aagctcgctt ccttttatgt tttttcagca tttgcggcgc 3278761 tttttcagct acacgaaata tgacgtatca taaaccgaaa tgtttcgatt gacacaaaac 3278821 ttttcaaatg aaaaaaacgc cataccaata gaatttgtta aaaaacgaat gcgataatgt 3278881 gttatgttcc caaataatgt gatacctcat atagaaatag ctaaaaattc agagccccat 3278941 gcccatacat tctcctagca cattaaacga aaaaataaga cgatagatcc agtccatttc 3279001 tgcaaaaaca cgtatcaatt tctggaaaac atggtataat aattgtaaca gaatgttcaa 3279061 aaaacaatca caaaacagac acaactcagt tcctctattt catttttgta aacgttatca 3279121 caaaatgaaa ggagacgggt atgatggaca tgttttttgc ttacttattg gttgccagcg 3279181 caacgcctct ctttatttgg cttgataaca aaaaagtcgc actctcagct attccgccaa 3279241 tcattttaat gtgggtattc ttcttctttt acgcaacaga aagcctttct ccacttggac 3279301 acactctcat gattatcttg tttgccgtta acgtcattgt cgctcatatc gccgcattta 3279361 tcatttacgg ccttccgtat cttcgcagaa agcgaagcag ctgaagacag caaaaaaccc 3279421 tcttccactg aagagggttt tttgtattat tcgttatggc ctgaatgctc tgagtgttca 3279481 gcgcctccag gaggatttcc gtccatatgg tcaccatggt gatagtgagc cgcgaaaatc 3279541 cagatggatc caagtacgat aacgatcgcg ccaaagaatc cgaacagcgt gtttccgact 3279601 tggatcgtgc cgttttcgct ctctgtcata tgcatgaaca tgagaagctg cagcgccgcc 3279661 tgaatgaagg cgaagccgaa gataatccaa agttttgctg atgagctcag gtcagtatac 3279721 actgcaaccc atagagccag cagggtcaaa acgatagaca ggataaaacc tacaatgtgt 3279781 ttccatggaa agtgactgtg ttcagcagat ttgtttgcca ttttacagac cccccaatcc 3279841 catgagatag acacctgtaa agatgaaaat ccatacaaca tctaagaagt gccagtacaa 3279901 gcttgagata aagattttag atgaagtttg cggagttaag ccgcgtttct tcaactgaat 3279961 cagaattcct gtgatccaga aaatcccgat tgttacgtga gttccgtgag ttccaagtaa 3280021 aacaaagaat ccagaccaga acgcacttgt actgagagcc gctccttcat gtacatagtg 3280081 aacaaactcg ttgatctcgc atccgacgaa gccggcaccg agaagaagag tgataattgt 3280141 ccaaatgact acgcctttta aacttccgcg gcgcatttca tgaacagcga tcccgcaggt 3280201 aaagctgctg atcagcagca agaacgtcat aatcattacc agattgactt caaatagttc 3280261 gtctggcaag acacctccag ctgttctgtt tttaagaacg aagaaggttg caaatagtgt 3280321 tgagaacaac acaatttctg cccctaaaaa gatccaaaac ccgagaatat taagtctgcc 3280381 ggtttcagat tgatattcca taggcgcgtt agaattgccg tgttctgcat gttccataac 3280441 tcacgcctcc ttattcggaa atctttcttt ccgtctcttt tatttcatca acactaatgt 3280501 agtagccgtt gtcgtattcg aatgaacgca gaaccatgca gagcaggact ccgatcaatc 3280561 cgactacgcc catccagtac cattcaaaga caagtccaaa gcctgcgaga ccgaaggcaa 3280621 cagacataaa gaacggtctg cctgagttgc ttggcatatg gattttcttg aatttgcttt 3280681 cagggtataa ttcagttttt tcttctttca tatgcaggaa tgcatcttga gatttgactt 3280741 caggaagcac cgcaaagttg taatgcggcg gaatcgcaga agaagtcgcc caatcaagcg 3280801 tacgtcccac accccatgaa tctccgctga tttcacgagt agagtaacgg aagctgtagt 3280861 agatgttata gcaaaggatt aagaatccta cacccatcat gaaagctccg actgttgaga 3280921 taaagttcaa tgttgtccag ccgtcattcg gtccgtatgt gtaaatacgg cgcggcatgc 3280981 cttgaagccc caagaaatat tgcgggaaga aacaaatatt gaacccgatc ataaagatcc 3281041 agaagaacca ttttccgatt ctttcgttca gcttgtggcc gaacattttt ggataccaga 3281101 aaataaatcc ggcgaaacaa gcaaatacag tacccgcaat cagcacatag tggaagtgag 3281161 atacaaggaa gtacgtatta tggtattgat aatccgctgc tgccatcgca agcataaccc 3281221 ctgtaacccc gccgataacg aagttaggaa tgaacgcaag cgcccacagc ataggtgttg 3281281 taaagctgat tcggccttta tacattgtaa agagccagtt aaagatttta accccggttg 3281341 ggattgagat tgccattgtc gtaattgaga agaatgagtt aacggacgca ctgttcccca 3281401 ttgtgaagaa gtggtgagtc caaactaaga aactcaatac agagatggcg ataatagaac 3281461 caaccatcgc tttgtaacca aacaattgtt ttcttgcaaa gcttgagatg atttctgaga 3281521 aaataccaaa cgccggaaga ataacgatat atacttcagg atgtccccaa atccagaaca 3281581 agttagccca aagcatcggc ataccgcctg cttccaatgt gaaaaagtga gcgccgaaca 3281641 aacgatcaaa tgataaaagt gctaatgcta ctgtaagtac agggaacgca aacacgataa 3281701 taaccattgt gatcagtgtt gtccatgtga acatcggcat acgcattaat gtcatgcctt 3281761 ttgttctcat ttttaagatt gttaccataa agttgatccc tgtcatcagg gtaccgatac 3281821 cggcaatctg aagtccgagg aggtagtagt tctcacccgg cccagggctc atgtcgttac 3281881 ttgcaagcgg catataactc gtccagcctg cgttcggaga acctccgata acgaaagaaa 3281941 tattgaaaag catcgcccct acaaagaacg tccagaagct caggttgttc aagtaaggga 3282001 acgcaacgtc gcgggcaccg atttgaagag gcacaacaac gttgataaga ccgattaaga 3282061 acggcatcgc catgaagatg atcatgattg taccgtgagt tgtaaaaatt tcattatagt 3282121 ggtttgagtc taaaaaactg ttattcggaa gcgctagctg ggcacgcatc atcagaccgt 3282181 cgacaccgcc acggaataac ataattacag cagatataat atacatgatt ccgagttttt 3282241 tatggtcaac agtagttatc cattcagacc acagccattt ccactttttg aagtaagtca 3282301 gaacaaaaat aatggcaatg gttgaaagcg caatggaaac ttgtgcgccc agaattaatg 3282361 ggtcaccagt tacgaaaaat tcgtcccatt tgaatttcat gcaggcttcc tcctttcctg 3282421 atcaatatca ttcttctgta tcatcagact tcttaaattc gtttttcttt acgttttcaa 3282481 acggatctgt tttagaatgc ggtgaaacgg cttgatagcc aaggcgtttg cgcgcctcca 3282541 tcgcgtactc agcgtcttgt ccgtgatcaa cgtatttcaa gtgagtagaa gagaacgtta 3282601 attcgtccac attttcagga agcatcaatt catcatactt ctcttttgtc agcttaggag 3282661 cctcgttctg agtctttttc acccagctgt taaagtcttt ttctgtgact gcattcacat 3282721 caaactcttg gtctgcaaaa tgttcacctg tgaagttcgc gttgcggcct tcgtaagtac 3282781 ccactttgtc agcctgtaag tattgatcca tcagcattcc tgccatcgca tatttttgcc 3282841 ctccaagctg aggaatccat agcgaagcca ttgaatctgc agatgagatt ttgaacaaga 3282901 tcgggcggtc gacaggaatg tttaagtagt tgaccgtttc aatatcctgt tcagggtagc 3282961 taaataccca tttccagtct accgaagtag cataaacaac aagaggctct ttgtcttttg 3283021 ttgcttcagg agctttttct aacgaatata tcgtctgtac tgttggcaca gaaagtgcaa 3283081 tgacgattaa aattgggatc actgtccaga ctacttctaa aaacgtgtta ccgtgaattt 3283141 ctgggttata agatccatta tctttgcctt tacggtcgcg gtattttact aaaataatgg 3283201 taaatagaac aaagacgacc ccgacgataa acagcataaa tccgatagat aacaggatta 3283261 aatcactttg ctgttcagct acaggtcctt tcggatctag tactgaagca ttgctgcatc 3283321 ccccaaggac gaaaaccaca gttaacagcg ctaatacaag caacggtttt aatgctctga 3283381 acaagaagat caccatcctt cctattgatg taataaatct gaagtgcata cttcctcaaa 3283441 atcttttctc tactttgtta tgctatcaaa aacttcactt attagcttta tttttttata 3283501 aacttcatcc cattttcgct taaatgtcat aaaatcgaca aaaattgctc caactttatt 3283561 cacatctatc gcttaagatg aaaagtttct agttatttcc gcatataaag taaagaaaga 3283621 tgatgaagaa ctaattctga caaattaagg tttaccacaa taaaaaactt aggtcaatca 3283681 aaaatttcat tttgttaaac tttctagata ggaattattt tttcctcgtc tagcatcttt 3283741 tcacacggtt accattttaa cgcatcaaat attgaaagaa aaggcgcaat gaagagccaa 3283801 tatgctctga attgtccgta tttttttatg agagcatcca gttgtttatc ttatacaaaa 3283861 aagaggaatg atataagcaa ataaataaaa aataggatgt gttgcatgat gagttttctt 3283921 atttcactta tcgtcgctat tattatcgga tggcttggaa gcctgtttgt aaaaggagat 3283981 atgcccggag gaattatcgg gtctatgatc gcaggtctta taggcgcctg gatcggacac 3284041 gggctgcttg gaacatgggg gccgcaccta gccggatttg ccattattcc agcggtaatc 3284101 ggcgcagcca ttgttgtctt tctagtaagc ctgttaacca gaaaaagagg ataaaagcag 3284161 cagcacccga agcgtcagcg ctttgggtgt ttgttttgcc ataaaaatcg aaaaagcctc 3284221 aaccctagcg gttgaggctt ttgactggtt tggcgcccaa ctgatcgatg aaccttctga 3284281 aggcctgttt tccctctgct gtctgcttaa atacaccggc gtgttcaagg atgcgcgcga 3284341 atacatgtcc cagctcttct tttatgacta gatctacgtt ctcttttgtt atggttcttt 3284401 tttccatcgt ccgaagagcc cactcactat gctttgcagt gagcggattt tgttctaagg 3284461 ctgttttcgg atcagcagaa catagcgccg ctgccgtttc tttcatttcc tcctgtaagc 3284521 ggccaggcaa tatcgccaat cccatgacct caatcaggcc gatattttct tttttaatat 3284581 ggtggacttc ttgatgagga tgaaatattc ctaatggatg ctcctcatcc gtccggttgt 3284641 tcctcagtac gatatcgagt tcgtacaagt ctcccctgcg ccgcgcaatc ggtgtgaccg 3284701 tattatgggg cgtatcgcct gtataggcgg caatgccggc tttttcatcg gaatacgtct 3284761 gccacgtgcg gaagatatgg tcagcagctt cggcgacatg acccggttcg tctccttgga 3284821 gcctgagcac agacatcggc cacttcacta agcccagcga cacgccggga taatcattta 3284881 attcataaac gtcttccgct tctgcacgtg ccattggaaa atcatgcgcg ccgccttgga 3284941 aatgatcatg gcttaggatg ctgccgccga caatcggcag atccgcgttt gaaccgataa 3285001 aataatgcgg atattggcca agaaatgaca gcagcctttc aaatgttttt ttgctgatct 3285061 ccatcggttc atgttcacct tttaagacaa tgcagtgctc cggataatag acatatggcg 3285121 agaattgcag gaaccattgt tcgtcctcaa ggatgaccgg aatgattctg tgattttgcc 3285181 gggctggatg attcacgctt ccctcgaagc cgacattttc tttacacagc aaacacatcg 3285241 gataatttgt ctgttcctgc tcttttgcag ccgcaatcgc tttcgggtcc ttttcaggct 3285301 ttgataggtt aatggtcatt tccagctcgc catattcggt cggcaccgtc caatgaacat 3285361 ttttggcgat tctgtcagtc cgtatataat agacatcctc tgaatattga tagaattcct 3285421 ttgtcgcctg ttttgggccg tataatgctt ttgtctcttc aaatttgcga atgacctcgg 3285481 acggggcagg cacaaaacag cccatcagct ttgcgctgag caggtcacgg tacgtatctg 3285541 tatccgcttc cattcggccg gtttcggcag cccatttata gatgggagct agcaagtccg 3285601 gcaggctttg tgactgcttg atgctggtgc tggagttcgg ctcgggatgt gtgatgccca 3285661 gcgcttcata aagacggttt ctcgtatatt cccgatccca gatcgaaatc aattttcgtt 3285721 ccaggccata ctcaagcagc tgttccagat gttcaataat actcatatgt cactccccct 3285781 ttagttctct cgctccctct ccgatatccg cgacataaaa gtccgctcgg agccctgttt 3285841 tttcttgata tctgtctcca accttctgaa taaaatcatc aacgaactca tcttttacaa 3285901 tgctgatggt gcagccgcca aagcctgctc ccgtcattct tgatccaatt acaccttcgt 3285961 gatcccatgc cgcaaacaca agctcatcaa gttcagggca tgttacttca tagtcatcct 3286021 tcaatgaaag gtgggattcc ttcattaact gcccgatttc atctatattg ttctctttga 3286081 acatatgggc cgtcttaata gcacgatgat tttcgtatac agcgtgcttt gcccggcgtc 3286141 tgttcgtttc attttggatc aggctggaat gcgcatcgaa atcagaaggc ttgatgtcgc 3286201 ccagtgcggc aatatcgagg ccttttttca gatcaagcaa tgcatcattg cattcttggc 3286261 gtctcgtatt atagctggag tcagccaatg tccttttttt gttcgtgttc gcgatgacca 3286321 gcgcgaggcc tgagacattg agtttgctat attcatagtc aagcgtgtca cagttcagca 3286381 gcatcgcatg atgttttttc cccattccaa ttgcaaattg gtccataatt ccgcaattga 3286441 cgccgataaa atggttttcc gcatgctgcg ccattttcac aagctcaagc gcatctactt 3286501 caggatgaaa ataactttgg agcacgaccc ccatcagcag ttcaatagaa gcggaagacg 3286561 acagtcccgc cccgtttgga atattccctg aaaatacaat gtcaaagcca tggggaactg 3286621 catatcccct ctgttgaaat tcataaatca cgccttttgg gtagttcgcc cagtcgtctt 3286681 ctttttgata gcgaatgtcg tcaaggctgc attccttgat gcctgcgttt ctaaagttat 3286741 ctgaatacat ccggacaagc ccgtcgtttc tttctgcaac agcagcatat gtacccattg 3286801 tcagcgcgca cggaaagaca tgcccgccgt tatagtctgt atgttctcca atcagattca 3286861 ctcttccagg tgcgaaaaaa aaccgtaacc cctctttttc tccgaataca cttgcaaata 3286921 tcccctttag ctcttcccgc atgtgcaatc acctttctgg tttttatttt ttattcccct 3286981 tatttcttca tagaaaacgg cagatcatat gctgcagtcc tctcataccc cttcttcttt 3287041 tgttttttta aagacgagcc atttgctcgc aacatagttg acgacaacaa tgaccgcgtt 3287101 gtcgagtatt ttggccaagg tttcatttgt attgaactgg ccgacaagaa tgatcatcat 3287161 gcctaaatct atgccgagag acaggacccg aacgctgaaa aaagcagtga gctctttcag 3287221 caggctctgc agatcatgtg ttttttgctg aaacacatat aatttatttg ttatgtaagc 3287281 aaacagcacg gacaaaatcc aagcggcaac agtggcggct ttgtaatcca cattcatgat 3287341 ctctaccaat atataaaagc tggcgatatt cacaatggtt gtgaaaaccc ccataatgat 3287401 atacataatt atttctctat acttcactga tgttcctcgc tttctgaaaa acttttcaaa 3287461 attcttggcc tctcgtgctc tctgtctaaa gtaaaaaata ccgagagtgc gtctaaaaag 3287521 ctgcggaagg tggctggctg gcccaataca tatgattgtt tgatgattcc gtcgaggact 3287581 gcacatatta ttttagccgt atattcagga tcaatacagg cgtcaatcag ctttctctcc 3287641 ttcagccact taatatataa cacattttct tccacccaca attcgtacag ccggacatag 3287701 gccttgcatt tctttaagac tttatatgtc ggcatgttca tggcaaacga ggtgatgtcc 3287761 cacgacggct tatttatgta ataggaataa agcagttctg cagcgtgttt tgcagcctcg 3287821 tccaatgtca gcgatttcac tgactcccgc tccatttgat caagataccc tataatgatc 3287881 ttttttttca tctgacgttt ttcgagaagg tacagcagaa aatcgtcctt gctgacaaaa 3287941 tgaacataaa atgctccttt gctgtacccg gcggctctgc tgatatcttc tacagaaacc 3288001 ggatcatacg ctcggtcaat caacaaattc acgccagcgt ctataaaact ttcaaatgtt 3288061 gcttctcttt taatttgaaa tttgtttttt ttcatatttt tctcctggcg gtaatgatta 3288121 cccttatctt acaccggatc aatctttagc ggtatttatt tctttaaacg gttatgctat 3288181 tcggtttccc aggggtcatt tttaataggc taaatgattt attttcattt acatactatc 3288241 cagtcagtat ttaattgttt attattataa ataaggtcca ttggttatat tagtcatttt 3288301 tttagggaat aggtaggtgg tttttccttc agtttgtgaa caccgagcaa ctatgtgtga 3288361 aatttgttgt actcgcctcc atcatcgcgc tggcttgtct tttattgccc gcatgttgca 3288421 ggaaaacatt ttatacaatt ggaggttact atgaaaactc atgttaaaaa agatttggac 3288481 aaaggttggc atatgttaat tcaagaagct agatccattg gattaggcat tcatgatgtg 3288541 aggcagtttt tagaatctga gacagcatca agaaagaaaa accacaaaaa aaccgtccgg 3288601 caagactagt ccgaacaggc ggatctattt acctctggct tttctatcac ctgatctgag 3288661 ttttcaccat atcctctatt caaaagcaaa tcgctgcgct gagcttgagg acaaacggtg 3288721 tgtcagctaa ctacgacaga cagccggtga tgcgatcacc tcttggcaca tgcattgtca 3288781 taaagaggtg atgcgaacat gataaccgtg ctctggtaaa cagcagcttt gctgagaaca 3288841 agctgcattc ggtgaggttt tgaaagcaaa ctcgtttata cacggccgag cttgaaaacc 3288901 ttcgcctgtc tttagaccac tgtgttcacc tcttcacgac ttccttcttt tttcatcctc 3288961 cagctattgt acaacgcata aatcggactt tcagtacata cctattggtg tacctttttg 3289021 cttacgttta gcgaataaaa ggaggaaagc catgtacaaa gctgattata aacagattgc 3289081 tgcaacgccg tcttttcaag cttttttaaa gcagaaacgc gcttttattg ttccttctgc 3289141 gattttcttt tttgtttttt atttttcact ccctgttttg acatcttatt tcaccttttt 3289201 gaatgcaccg gccattggag ctgtttcatg ggcttggctg ttcgccatcg cccaattcgc 3289261 tatgacctgg atactgagta ctgtgtattc ccggagagcc gcccatttcg ataagtatgt 3289321 aagcgcttta aaagaggatc tgaagggtga acagacatga atatgactgc ttttttatta 3289381 tttttggcga ttgttggcct gacgcttatt atcacgtatt ttgccgcgaa gcggacgaaa 3289441 acgacgagtg agttttatac ggcgggcggc gggctcaccg gcgttcagaa tggactggca 3289501 attgccggtg actacatgtc tgccgcctcg tttctcggga ttgccggaat gattgcgtta 3289561 tatggatttg atggcttctt ttacagcatc ggttttctgg tggcttatct cgttgtcttg 3289621 tacatcgtgg cggagccgct tcggaatctt ggaaagtaca cgatggcaga catgattgcc 3289681 gctcgcttta aagaaaagaa aatccgcggt gtcgcggctc tcaataccat tgccatctct 3289741 actttttata tgatcgccca gctcgtgggg gcgggcgcgc tgatcaaact gcttctaggg 3289801 ctggattata ccgcggctgt cctcatcgtc ggagtgctga tgaccattta tgtcgtgttt 3289861 ggcggcatga tcgcgacaag ctgggttcaa attattaaag ctgttttgct gatggccggc 3289921 acactcgtga tttcgattat cgtgttttcg aaattcggct ttagccttaa taccatgttt 3289981 gaacagatga aaacggctac tccgcttggc gctgattttt tgaaccccgg aaataaatac 3290041 aaggtgccgc ttgagacctt gtcgttaaac ttggcactcg tgctgggaac cgccgggctt 3290101 ccgcatatat tgatccggtt ttataccgtt aaggatgcca agacggcccg tacatccgtt 3290161 gtgtcagcga catggattat cggtgtgttt tacattatga cggtatttct cggctttggt 3290221 gccgcggcat ttgtcggttt tgacgcgatt acggcggctg atcaagcggg aaatatggcg 3290281 gctccgcttt tagcaaaagc gctcggagga gactttctgt tcgcgtttgt atcagccatc 3290341 gcctttgcca ccattttggc tgtcgtgaca gggttggtgc tgtctgccgc ctcagcattt 3290401 gcccatgata tttacagcca gatcatcaga aagggagaag caactgaaaa agaacaaatg 3290461 aaagcggcca gatgggcttc tgtcgccgtg tcagtgctct cgattctcct tgcgattttt 3290521 gcacaatcct taaatgtggc gttccttgtt gcactcgcgt ttgcggtagc cgccagcgca 3290581 aaccttccgc tgattgtgtt tacagtcttc tggaaacgat tcaatgcctc aggcgcttta 3290641 tggggcagcc tgacaggcct gatcagcgcg cttgtgctgg tatcgatgag ccctagtgtg 3290701 tgggacccgg ccggaggtgc tatttttacc ggtgatccgc tcattccgct atctaatcca 3290761 ggaattattt ccatcccgct cggctttctc ggcgcgtggc tcggaacggt gctgtcgtct 3290821 gataaaacaa ttgatgaaga tacgtttgca gaaattcagg tgaaggcgca tactggcgtc 3290881 catatggaac aggaataaaa aaagctctct ttatcgagag ctttttcctt actttttctt 3290941 ctgctcgtca gaaatcgctt tttcaaatac atccttgccg gcagcacccg gaattacagt 3291001 gtcaccgata ataaaggttg gaacggctgt gatgtcagcc tcttcatagg cgtgcttcaa 3291061 ggcttggcgc tgcacgtcct gatatgttct tgtttccagt gctgatttga atgatgcacc 3291121 gtctaatccc acttcctcgg cgagcttcgt caagatgtca atatcgccga tattttggtc 3291181 ctcctggaaa aatgcctgaa agacacgggt gttgtattca tgtcctttat tgtattcctt 3291241 cgcaaaatgg aagccttcaa acgcgaggtc tgtatacgga tggggcgaga cgtttggaaa 3291301 attgatctcg actcctaatt tctccgccat tggctgaatt gatgtctgcc acatgtactg 3291361 tttagaagga tcattgaccg gatcaagctg aggagatggg cttgggcgca gttcaaacgg 3291421 catccactcg acttcaacat cctttccttt tatcgcttct tcaaaagcgg cttttccaac 3291481 aaaacaaaat gggcagacgt aatctgaata aactttaatg tgtactgtca tgataatctc 3291541 ctttcatact aaattgattt taaactgtaa caattaaagt tacaactgtt ttttaataaa 3291601 gaagccgatt taggcttctt tcagattgat gacaaaatcc taaaaagttt taggattttg 3291661 tcatcctttc agcgtgattg aaaacccttg aagtctagga aagccgagca ttggagcgga 3291721 gcgaatgctc taattcgtga gcaccaacgc acaggcttga caacgaatgc gagggtttgt 3291781 cgacacgctg aaagaagcct gtaaaggctt cttttatgat tccagcaaac gctgggcaat 3291841 atattctcct tttttgcagc cgcctgggca tgcgtataaa gcagaaccga ttgtttgtgt 3291901 atattcgttt aacgcatcct ttgctgaaag agccttcagc atcgggataa actgattgtc 3291961 gggatttttt tgaaaactga taaacaggag acctgcatcc atatagccgg ttttcggatc 3292021 aagtccttct gtgtaagaga aagctcttcg caaaatttgt ttcccagtag atttcgctag 3292081 actgacgtgt gaattagacg gaatttgatt cagcttcacg ggatctgttt cctttttctg 3292141 cccaaaaggc gcccccgagc tttttctgcg gccgaaggta tcctcttggt ccttgaggga 3292201 agagcggtcc catacctcaa ggaacatttt gattttccga aaagccatat aggtgccgcc 3292261 cgtcatccag tcaggctcac cagactgaat ccacacgatc gagttcatca acgtgtcatc 3292321 cttcgtgctc tggttgcctg ttccatcttt aaacccgaag aggttgcgcg gtgtttcacc 3292381 attttttcca ccgcttaaaa agcctttgtt cacaaaacgg acctcacaag tgccgaccgc 3292441 ttgatttagc aggttacgca gcgcgtgaaa cgccacttgc tcgtcgtctg cacacacttg 3292501 aatgcagatg tccccgcctc cctgcttttc atccaggttg tcattgggca tcgctggaag 3292561 agcggctagg tgcttcggtt ttttgctttt cagtccgaag cggtcctttc cgtctttttc 3292621 aaaaaagcca ggcccgaatc cgaatgtgac cgttaagttg gaaggggata aatcagcaga 3292681 ctcacctgta tcctgcggcg gcagatactg atttctctgc tccgctgaca ttttcttgcc 3292741 agacgtcagc atctgtgtga gacttgtcca gtttctaaat aacgtaatga tgtcgctttt 3292801 gtcttttgct gttacatcca gtgcagcaaa atagacatac gtctgatggg cagttgtgat 3292861 tccggcctga tgctttccgt aaaacggaac aatctgctcc tcctcttttt catccttttt 3292921 cgatggctta gccgcagtct gaacaagcgg agcgagaccg ccgagaccgc tggcaccgat 3292981 cgcaacggct gcccccgcca tcgctcccca ttttaaaatg tcccgtctgt gaatttgttc 3293041 tggctttttc tgttcatcgc tcatgatgtt acaaaactcc ttttatagca cattcgcaat 3293101 cttcgacatg gtttcagaaa gagtcgtcag cttagtgctc agctctctga tttgcttttc 3293161 acttaattta tcataagacg tataggactg atcatttgtt ttgtattttg ccattaaaac 3293221 ttcaaattcg ctgaactccg tatccagttt ttccgtcaag tcggagtgat cttttacaag 3293281 cgcgcttttc actgtttgat aaacggcttc ggagccttcc acatttgcca taaggtcaac 3293341 taaatcaatt cgtgagtagc gctcttcttc tcccgtgatt ttcgaaattc cggcttcgtt 3293401 cagaagctcc atcgcgcctg caacaatttg ttcaggtgtt aatttcagtg attgaattga 3293461 accgtcaagc tcttttacat ccttgagaag ctggtcagct gttgcctttt ccccggaaat 3293521 atcttgatcc ttccaaatgg ccttctcaag cttatggaag cctgtccatt tgtctccttc 3293581 ttcaacatcg ttttctcgtg cgtcaatttt cggatcaaga tctccgaggc tttcagcgat 3293641 cggttcgatt cgctcgtaat aaacacgcgc tttcgcatat aacgttttgg acttttcgat 3293701 atcgccggat ttcacagcac ccgtaaatgc ttcagtcgct ttgacaagct ggtcactctg 3293761 ctctttgaca tagcctttat actcatccgc tgcttttgcc agctgatcgc tagccttttt 3293821 gccgctcttc ttcgcttctg tcaggtcttc taaggatgct ttcaatgact cggattctgt 3293881 cttgattttt cctgcatccg gtttgtcttt ttgcgcttct gtgtagattg gctgaagatg 3293941 cttttcgatt tctgtatatt cgaatggata gtcgctgcga atatcgtttt caaaggaaag 3294001 ccagtagctg tttaactctt tccccttctt ttcaatctct ttttggtctc ctttttccac 3294061 tgagtcattc agcttagaaa tgatggtttc cattttattt acggatgcgg tgatttcttt 3294121 agtgaccccg cttttttcag atgaagcttt ttctttggtt gaagatgtgt cattggctcc 3294181 gcagcctgcg cacagcgcaa ggatgcatcc ggctgataca gcgatttttg tgaaattcat 3294241 tttgtcagtt cctttccgtt tgtaaaatgt tttgccgctt ctgaaacaag cgcaatcagt 3294301 aaaaagagta aaatcaacat ttgcggaatc gtgctgtaca cagacggata aattcctagc 3294361 accgatacag acggcagcca gctttctgca tcagacggaa gaatgcccgc cagttgaagg 3294421 ctgtgaacgc cggttccgag aaatttcacg cacatataca ggacaaccgc cattgataga 3294481 agaaaaaacg gcttcaatgg aatgcgcatt ccgagcttga tcatcagaac accgacgatg 3294541 acgagaacga taagccctgc ggcagttccg ccgatcagtt cagtgagcgg gagcttcccg 3294601 acaagcccga tgaaaaagat gaccgtttcg agaccttctc ttacaactgc cagaaatgca 3294661 atgagcgcaa aggaaagcag gcttcgtttt tttagtgcct gtgacttctg gatattgatt 3294721 ttttctctcc atttatccat tgaggcgttt ctgtgcagcc acaccccgac atacaaaagc 3294781 atgacagcgg acagtacgcc ggtaacgccg ccaagcaaga aattgttttc tccgaataca 3294841 ctggaggaga acagaaccgt gacaccgatg ccggctgcta aggaaacagc catgccggcg 3294901 gacgccccgc cccagatcca tgtcgaggaa cgcgtaaccc gcgctttttt tgtcatggtt 3294961 aatagcgctc cgatgacaag gagggcctcc attccttcac gaaccgggat cagcgccgca 3295021 tcccaccagc tgtagctgct tgaagcgatc ggctcgagca attgaatcat ttcgtcaatt 3295081 tgctttgata ccttttcagg atggctgccg atctccgcct tcatcagcgc cagattttcc 3295141 tccgatgtcg tataggcttc tttcgattgg gacacgacat ctccctcaac agcgagccag 3295201 gatgtaacta aattgtcgat tgcggatgac gcttcatcca attgtttttt ttctatgaac 3295261 tgttttgtgt ctttcaagct ttgtatatag gctgttaagg acgcccttga ttgacctgag 3295321 gatgtctttt tcagcacgac agcctgctga taggtttcta aatgagacgc aagctcttca 3295381 agctgtgttt tgagcttacg tgcgtcttga ttgataaaag aaagagaaat catcgcgata 3295441 ttcgcgtcca tttcactgtg agaagaaagg ttttctttct taatagaagg ttcttctttt 3295501 ttccacttcg ccttgaaggt gtcaaacgtt tgttgtgccg aatccatatc cccgtctttt 3295561 acggatttga tcatttgctt gtttaattga attaatgcgg cgatcggatc atcttccgca 3295621 tgtgccgcag aaccgaaaac catcaacaag ctgaatagaa taagtgccag cccccgagcc 3295681 atcatgttcc tcctataatt gaaaatgatt atcattgtat aacataatca tagccagttc 3295741 ctgtcctttg tcaattaaaa tttgaaggtc tgaaaacctt gatggacagc aaaaaagctg 3295801 tccttttaca gaacagccct ttgaaggaaa atgaacgatt atcttcctgt tttatacgtt 3295861 tgaatttcct cacgaaactt gcgtgcagca ctctcaggat cctccgcctg actgatggcg 3295921 ctgatcatac tgacgccatc ggcccccgct tggataacag gtgcggcatt atctattgtg 3295981 attccgccga tgccgacaat tggaatgctg atgccttggc ggcgcactgc ttcgataaga 3296041 gatacaccct gtaccgctct cgtatctttt ttcgtttcag tcggatagat cggcccaagc 3296101 ccgacataat ccgctccgtc ttcttcggct tgcttcacct cagacatcgt atgggcagaa 3296161 acgccgagaa tcatatcacc tatggcagct cttacctctt tcgcatttgc gtcttcctgg 3296221 ccgatgtgga taccatcagc tttcagattc agagccaatt ccacatcatc attgacaatg 3296281 aacggaacac cagcttcacg gcaagctgcc tgcgcttttt cagcaaattt aatccgagcc 3296341 tctcctgtca gcgcatcccc gcctttttca cggaactggt acagggtggc accgcctttt 3296401 aacgcttttt gtacaactgt aacaggatcg gctttcgtat tgtttgaccc cataatgaag 3296461 tatacagata ataactcttt catcatttcc cgagaaatac gagtcatgag acagtcaccc 3296521 tttctatagt cgcccattct tggacgtctt gttcagtaac agttgaaagc ttgttcagca 3296581 attcaatctg aaagcttcca gggcctttgt cagccgtctg ctgtgcggca agctgagcgg 3296641 cgaccccata cgaagaaatg gccgcaatag cagcaaacaa tggattttct tccacagcgc 3296701 aaaacgcacc gacgacggaa gtcagcaggc aaccggcgcc tgtcactttt gtcagcagct 3296761 tgtggccgtt atgaagggtg tatacatgtg acgtgtcggc tatgacatca acttcaccag 3296821 ttatcgcaat gaccgtgttt agcttttgtg ccgcctgctg agccagccgg atgatgtcgc 3296881 ctccaccttc acccgcatca acacctttga tcagccaatc ggtcacgccg acggtatggg 3296941 caatttccgc cgcatttcct ctgattgcag caaggcgcac ctcacgaatg atgtcacgtg 3297001 ccgattcagt gcggaacggt gttgctccgg caccgacagg atcaagaatg acgggaacgc 3297061 catgttcatt agctgatttt cccgcgatga tcatcgcttc gactgactcc ttgctcagtg 3297121 ttccgatatt taaaacgagt gcacccgcaa ttttcgccat atcggcgacc tcttcttttg 3297181 cgtacgccat aacgggcgat gcgccgagcg cgagcaggcc gtttgctgtg aaattcgtta 3297241 cgacattgtt ggttatgcta tgcaccagtg ggctatgccg gcggacagcc gtaagacatt 3297301 ttgctgctga ttgtgcatcc atatttgcat catcctttac tatctttttt cgggtcccat 3297361 aaatacgatt tcgtatgttc gagccaagct ctggcggcaa acgacaagta cctgtccttt 3297421 ctccaaataa tggcgaggtg ccaagggatg accggatcga caagcggaat gactttcact 3297481 ttttccgggt caaggccgcg gcagatccgt tccggcaaaa gcccgatccc aaggttggcg 3297541 gataccatct cactaataaa atcccattgt gatgtttcat aaatgatatg gggccggaac 3297601 ccagccttga tacattccgt cataattcgg ttgtgcagga caaaatcctc tctgaagaaa 3297661 ataaaaggct cgtccttcaa ctcacgcagc tgacattctt tctcatcagc cagccggtgg 3297721 gaagggtgaa cgacaagcat taaggtttct tttacgattg taaacgaatg aaagatatct 3297781 tcgtttgcgg gaaggaccac aacgccgata tcaagagagc cgtccccgac accttcttgg 3297841 acttttatag aaccgtcttc gactagctga aaggtgacat tcggatagtt ttcacggaaa 3297901 tcgccgagca ctctggggaa aaaccccgat ccgatcatcg gcggcagtcc aatccgtacg 3297961 tgccctttct tgacttccat aatatcattt aattctgacg tcaggttttg aaatgattta 3298021 atgatttcct gcgcctgcac atacatgcta tgaccggcat cagtcagttc cacctgcctg 3298081 ccgtttcggt aaaacagttc aattccgagc tcttcttcta aatttttgat catttttgat 3298141 atcgtcggct gagaaacata aagggattgg gaagccttcg taaaactttt taaacgggcg 3298201 acttccaaga aatatgttaa atggcggata tccatgcgct tcaccctttc tatagacaaa 3298261 aggaatactt cttattctta atatatattt tacctataga gagaccttat gtacaataag 3298321 tatataaggg aggcatcaat atgaaaaaac tgttgctaac cgttattcaa atcgctctgt 3298381 tatttatatt tgctcggctg attaattggg tgacagccct tcttcatata aatattcccg 3298441 gcagtataat agggattgtg attcttttca cattattgca ctttaacatt atcaagcttg 3298501 aatggatcga gcttggtgca gcgtggcttc tcggggagct gcttttattt tttatcccgt 3298561 ctgccgtcgg agtgattgaa tacggagaca ttatgtcgaa atttggtgtc agcattctgc 3298621 ttgttgtcat catcagcacg tttgtcgtga tggtgtctac aggaacgctt acacaactca 3298681 tcgcaaagag aaaggagaaa aagcatacgt gttcatcgga attgtaagtt tgtttttaac 3298741 ggttttggtg tatttaggag caaaaaaggt atatcaacgc tttccgcgtg tttatacgtc 3298801 gccgctattg gtgacgcccg ctgtattagt cggtctgctg ctgctggtga atgtcccgta 3298861 cgagtcctat aatctcggcg gcggattgct gaccgatatg ctacagccgg ccaccgtggc 3298921 attcgcgatc ccgttatata aatatttccc tgttttaaag aaatacgcag tggaaattat 3298981 tttgaatgtg gccgtcggtt catgcatcgc gattatttct accgctctta ttgcgaaatg 3299041 gcttcacctc ggcaccggct taattgacag cctcgtccca agatcagtga caacgccgat 3299101 cgcgatgaac gtatctgaaa tgatcggcgg tatgcctgcc gtcacagccg tgtttgtgat 3299161 tttaaccgct ttgctcggca cagtgatcgg cccgatggtc atccgttatt tccgcattga 3299221 taacgaaatt gcgcggggcg tgctgcttgg cacaagcgcg cacggagcgg gaacgtcaaa 3299281 ggcatttgag ctcagctctg tgtccggcac gatttccagc gtgtcgatga tcttagctgc 3299341 gattatgacg ctttgcgcgg cgccgttttt gctttcattt atgtaaaaaa ctgtcctctc 3299401 gagggcagtt ttttttatgt gcttcccctt attgaaaagc tggcgaattc caatataatg 3299461 tatttgtgga taccaaagga ggcaccctga tgcacaactt gcaggtgagg cggcattatg 3299521 ccgcgttaaa aggattttat ttgtttgctt ttctcggtac gggcagcata attcccttac 3299581 tcagtatgta tttaacgaag gaacagcatt taagcggatc acaggtcggc ttgatcatgt 3299641 cactgggccc gattgtgatg attttctttc agccgttttg gggcatgctg agcgactata 3299701 cgcaaaaaac gaaaggcctg ctggcggttt gcacatcaat cacaggcatc attggattag 3299761 cctatattgc atttgacagt ttccctctgt ttattttgat tgcggcctgt tttgcagcct 3299821 ttcaaagcac gattattcca ctttcggaca gcatttcact aaggtacaca caagaaacaa 3299881 acggcaacta cggcggaatc cgcctgtttg gttctctcgg cttcggtgtc gcggtgtttg 3299941 ccatgggaca ggtgacgaac cagctgtacc ccattcacgt gatctttatc tttggctgtg 3300001 cctttctgtg cattgctgcc atattggctt cacaagtgcc cggccagcag aaaacaacaa 3300061 aggtcaatat ccgcaaagga ttccgggagc ttatcagcaa caaaactttc ctcatcttta 3300121 tgatcatcac ctttacgaca tttgctccaa acttagcgaa caatacgtat ttcagtcttt 3300181 ttctggacaa aagcggcgcg tcactttccg ctatcggcat tttatttttc atcggtgtca 3300241 tttcagaaat tccatttatg agattcgccc aaacatttat agataaaatg gggctgctca 3300301 acgtcattat gctgtcaggc ggagtctcat tattcaggtg ggcgctctat ttcacggcgc 3300361 cttcactatg gatcatttat gcgacggtct ttcttcaggg agtggccatc ggtttattta 3300421 tcccggcggc gcttcaatat gtgaaaaaga ttaccccaag acacgttgaa gcgacggcgc 3300481 tgaccatgta cgccgccatt ggcaacgggt tcggcaactg gttctgcaca tttgcaggcg 3300541 ggtacatttt tgactacgtg tcgatcttcg cagtctactt gctttttggc attctgagca 3300601 tagcaggctt tggcctgaca ttatatttaa tgaaggctga aaaaaacaaa catacacttc 3300661 atcagccggc tgttactttt aaaccataat gactataatg aacaaaagaa aggatgtgcg 3300721 ttatgaacgg gcaagagcga aacagcattt cgaaagggtt gcaggttgat attgtattga 3300781 aagcagatca aaaaacagga aaactgacga gagggacagt gaaggatatt ttgacgaaat 3300841 caaactttca tccgcatggc attaaagtcc gtcttgaaga tggccgcatc ggccgcgacc 3300901 agcagatcgt ttctacataa aaaaaagctg cccctgaaca gggcagcttt ttcattattt 3300961 tttctgcaga aggaccactt tcaggtagtt gccttccgga aatgccgaaa tcgttttgaa 3301021 atcctccggc agcgtaaatt cctcaatgat cgtgtagcgt tcatttgttt ctttaaaggc 3301081 ggcatcaata aagcctttga acttcttcat gccaaaggcg ctgctgtttg tagaggcaac 3301141 aatgacaccc ttgtcagcag tgatggcgat cgtttccttc agcaggtttt tataatcctt 3301201 ggccgcgctg aaggtgcgtt tttttgtgcg cgcaaaggaa ggcggatcta gaataatcag 3301261 atcaaagcgc aaatcctttt ttgcagcata tgaaaaatag ttaaaaacgt ccatcacttt 3301321 aatgtcgtgc gcttcgtaat ccagcttgtt cacgctgaat tgctcgatcg ttttggcaag 3301381 acttcgattt gccacgtcga cgcttgttgt tttctccgct ccgccaagcg ccgccgccac 3301441 ggagaatgca cccgtataag aaaacgtatt taaaacggtt ttcccttttg catagcggtc 3301501 tctgatcgcc ttgcgcacat gtctctgatc caaaaagatg cccgtcatgg cgccttcatt 3301561 cagatccacc gcgtattgaa tgccattctc ttggatgatg atcgggaact cgccccttct 3301621 ccctttcacg aagtcatcat cttcaacgta ttgtccagcc gtgtcgaagc gtttcttctc 3301681 gtaaatcgct ttataatcaa gatccatctc atccaatgcg gaaatcagca tgtctttaaa 3301741 ggtgtaaatt cccttgctgt accattgaat cagcaggtag ccgtcataat agtcgatggt 3301801 gacgccgccg acaccgtcac cctcaccgtt gaacaggcgg aaagctgttg tatcttgagc 3301861 ctcaaatagt ttggcgcgcg cttgggccgc ttttgttaat ttgctgagaa aaaatgcttg 3301921 gtcaatctgt tcatgtttat tgcgggtaag cgtccagcca acccctttgt tttgcaggcc 3301981 gtaatagccc cgcgcgagaa actcgccgcc gctctcagac acgatatcaa cgaggtctcc 3302041 ttctttcatg tgccccgcac tccctgcgag agcttctttt tcaataaggg gatagccttt 3302101 ttttattttg gcagcgtgtg ctttttttag ggtgagtagc ttcatatatg tcgtcctctt 3302161 tccgtttgct ttctcttatg gtaccacaaa acgccaagat gtctgcattg acagaaagga 3302221 aaggtttttc tacgatagac aaaaagagtt acgaggagga gcagcatggc aaaacgaatt 3302281 gaccatacag gcatcatggt aagagatatt aacgcgtcca tcacatttta tgaagaggta 3302341 ctaggcatga aattgaagga tcgcatcact cacacgaacg gtgtaatcga gcttgctttt 3302401 cttggctttg aagacggccc ggaaacagaa attgaactga ttcaaggcta cagcagcgag 3302461 cttcccgctg aaggaaaagt gcaccacatt gccctgctga cggatgacat cgcggctgaa 3302521 tatacaaaag cggaaaaaat gaacgcaaaa tttatcgacg aggagatcac aacacttcca 3302581 aacggatacc gttatttcta tatcgaaggc cctgacggtg agtggattga gttctttcag 3302641 cggtaaaaat aaagaacgta cattttgtga tgtacgttct tttttatcta taccaactga 3302701 tatacggcta tacagccatg aacagcataa aatgaacgtt attacagtta tcaccacata 3302761 tggcgggatt gtgactgggc aggcaggcaa gacccaatga tgcaaaggga gtattaatgc 3302821 ctaaaaaaca gggcatttta actcttcttt tcgtgttggg ctcataacgg cgccttggac 3302881 aaccccctat tctcatgctc cgtcgtcgac gcgggcattt ttgtcatttt cagccggtat 3302941 ttctcacttt tttcattttg attgtcaact tttcatttga tacgatgaac aagccgactt 3303001 ttcttcagca aaggaggttt taattgcttg cataaagaga ttgcaaaaga attactgctg 3303061 ctcgcaggag gaaaaaacaa tattatcagc atcagccatt gtacgacccg tcttcgtttt 3303121 gatgtaaagg acgagacgaa aattgatata catgccattg agaacctgca aggtgtgcag 3303181 ggcacctttt tccgctatgg gcttttccag attatcttcg gagcaggcgt cgtcaacaaa 3303241 atatataaag aagtcgttca tgtatgggag accgcgcctt ctgaagagcc tgtccaccag 3303301 aaaaaagcca gccggaagct gaaccctgcc gcagcttttg cgaaaacact gtccgatatt 3303361 tttgtgccga ttattccggc aataacagca agcggcctgc tcatggggct gatcggcatg 3303421 attaaggtgt ttcattggtt cgctgccggc agcccatgga ttaaaatgct cgacctcgtg 3303481 tccagcacag cctttatttt actgccgatt ttagtcggct tcagtgctgc acggcaattt 3303541 ggcagcaacc catacctagg ggcagtgatt gcagggcttt tgacgcatcc tgatctgctg 3303601 gacccgtcta tgctcggcag caaaaccccg tcttctttag acatatgggg gcttcatatc 3303661 ccaatgatgg gctatcaggg ttccatgata ccgattcttc tttccgtttt tgtcatgagc 3303721 aaaattgaga agctattaaa atcgattgtg ccgaagtcgc ttgatgtcgt gatcattccc 3303781 tttattacgg tcatggtgac agggtgcctc gcgctgattg tgatgaatcc cgccgcgtcc 3303841 atcatcggcc agatcatgac acaatcgatc gtctatattt atgatcacgc cggcattgct 3303901 gccggagctc ttttcggcgg catctactcc accatcgtcc tatctggatt gcatcatagc 3303961 ttttatgcaa ttgaggcaac gctgcttgct aatccgcatg tcggtgtcaa ctttttagtg 3304021 ccgatatggt cgatggcgaa tgtggcccaa ggcggagcgg ggcttgcggt attcctcaaa 3304081 acgaaacaat caagcctgaa gaaaattgcg ctccccgctt ctctgaccgc gtttttaggc 3304141 attgttgagc cgattgtatt cggggtaaat ctcaaattga tccgtccctt tatcggagca 3304201 gccatcggcg gtgctattgg cggagcatac gtggttgcgg tacaagttgt ggcaaattcc 3304261 tacggactga caggcattcc gatgatttca atcgtgctgc cgtttggcgc cgctaatttt 3304321 gttcattata tgatcggttt cttgatcgca gccgtctctg cttttatagc tacattgttt 3304381 ctcgggttta aagaagagac agaataactg gatttattcg atttcattca taaaacgggg 3304441 gatgaaagga caaaaaagct atgaaaatta aaagaatctt aaatcataat gctatcgtcg 3304501 taaaggatca aaatgaagag aagattctct tgggtgcagg aattgcgttt aacaaaaaga 3304561 agaatgatat tgtcgatccg tcaaaaatag aaaaaacctt tatcagaaaa gatacacctg 3304621 actataagca gttcgaagag attttagaaa cattgcctga agaccacatt cagatttctg 3304681 agcaaattat ctctcatgcc gaaaaagagc tgaacatcaa aatcaacgag cgcattcatg 3304741 tcgctttttc agaccatctt tcttttgcaa ttgaacgcct gagcaatggg atggttatca 3304801 aaaatccgct gctgaatgaa atcaaagtcc tttatccaaa ggagttccag atcggcttat 3304861 gggccagagc actgattaaa gataaactgg ggattcacat tcctgatgat gaaatcggca 3304921 atatcgccat gcatatccac acagcaagaa acaatgccgg cgatatgaca caaacgcttg 3304981 atattacaac aatgatccgt gatattatcg agattatcga aattcaactg tctattaata 3305041 tcgttgaaga taccatctct tatgaaaggc tcgtgaccca tctccgcttt gccattcagc 3305101 atatcaaagc aggcgaatcc atttacgagc tggacgcaga aatgattgac atcattaaag 3305161 agaagtttaa ggatgccttc ctgtgtgccc taagcatcgg cacctttgtg aagaaggaat 3305221 acggctttga gtttcctgaa aaagaattgt gctacatcgc catgcatatt cagcggttct 3305281 accaacggtc agtcgcacgc tgagacaaac aaaaaacgct tttgatcatc tcaaaagcgt 3305341 ttttttatct gatttattgg ttgatcgccg gattcccaat cgtattccac ttcgtatagg 3305401 acatgtaatg gaaatactca tcgcgatacg gatgttttgt attggagttc caaggctttt 3305461 ctccgccgca gaagtgcacg attgccgggt tttctcttgt ttcattatat tgcttccgcc 3305521 ctaacagagt cgatggggtt ttcagcttta acatgatata ggtttgagcg ttccagcgcg 3305581 gatgaagttc ataccactga tcatacaaga tcgcattcag tgcatcttgg tcatgcagca 3305641 caagaaagtc ttcgtctggg tgttcattga taaagttgat gactttttct gtgatgtttt 3305701 gctttctcca agactcaaaa tcaataatca tgatacctga gttaaaatac ttccctgtat 3305761 cagtgacgtt catttctttc aggcgttcat gctgccccgc atcctcaaca gcggctacgg 3305821 tgtatggcgc aatgtctaag tcccatagct tagaaatatc ctctaggaca agcgcatcac 3305881 aatcgatgta aatcattcgt ttgatgcttt catccttaat taagtcggga atcgaaatgc 3305941 ggtaatacgc ggcttttgta atatggctgc tctcaaccgc atgttcatac atgttggtat 3306001 ccacttctaa aaactcaatc ggcactccga atttcaaagt ggtttcttcc agtctttttt 3306061 tgttatcagg cttaattccg ccatcaatga cgtataattt tacctctctc tcctgatcca 3306121 tgttagtcaa taaagaaacg aacatcccac ctaaatgacg agcataatta tcatctgcgc 3306181 atgatacgat atgcatgatt tcatctttcc tcaatggtat tcatctccct ttttgttgta 3306241 caagttacat accctttttc aaaaaaataa acacgttctc cgacattttt ttaaacagaa 3306301 tgtgtgatac aacaaaaaag gtgtcatttt ttgaagatgc gataaagcca ataaagaatg 3306361 aaaaagcttg cgattgtgat ggcttcagcc gagacgatat accacggcca tggcccgaga 3306421 acatctaaga gagaggaacc gcccggtttt ttcgtcaaat acatataatt cgcgccaagc 3306481 cagcgatcaa tcagaaaaat acagacgccg tacacattaa caagcaggac tgtcacccat 3306541 aacgagcgct ggcccattct gtaggtgcca atcacagcca tcagcagaca ggataaaaac 3306601 acagacccgt gagaaataaa aaagaggata tatcggatat gcggaaatga aaacataccg 3306661 aggtcaggag tggcaagagc ctgaatcgaa ctgccgatgc cgacaaaaaa caaaaacaca 3306721 aacagctttc tgctttttgt cactaacata atagctgaca aatacaccga caggtcacta 3306781 agctggagag gcaatgaagt gcgcaccgac cacctgtccg tggcgaccat ccatatttga 3306841 tagccgattt gcgaaccaag caaaagaaac acaaacagag aacgcaaaaa ccggctggcc 3306901 ctcggctgct tgacctcatc ttggaacaaa aacaacagaa tggccaaaag ggagataatc 3306961 gctaacgtca ctacatgctc tgtcgaaaac agatgaaacg gatcatgctt atagtcggat 3307021 tgaacatatt tttgcaaaac tgcacccccg ttttcgggtt tttgtttatt ttggcgttgt 3307081 ttgggctttt tttattcaac cgatatatgg gcttgaagtt cacaccagac tctgttaaaa 3307141 ttcgtttcat agctaatgat tctgataatt taaggcaggc ctaaaaaatg gaacgttcac 3307201 atcaacatca gcagcttcgg aaggaagaac acgatacact ttctaagctc aaacaaatgc 3307261 ccgtcgagtc actcaacctg gaagccattt cgatcgctac gaatctgtat cggtctgcac 3307321 aaaggctccg tgtcaaaatg gagactgagg ttctttctac ctataacctt tcttggaccg 3307381 ctttctccat tctttatgat ctatgggtat ggggagcgct cgaaacgaga aaaatcgctg 3307441 agctgtcagg gatatctaca gctacagcaa gcaacgtgat caaaacgctc gaaaaaaaga 3307501 gtttttgccg taaaagcatc gacacaagag atcggcgact cgtgtttgtc tcaatcaccg 3307561 attccggcaa acaagcgatc gaagaactct acccggagtt tcacaaaggg gaaacagagc 3307621 tcattgcggg aatgacgaag gacgaacaga aaatattgac agggctgctt agaaaggtag 3307681 ctgacaatct tcatacaaca taagctttga cgggaatcca gtagcggttt gtctccctgt 3307741 ttcagagagc cggcggtagg tgcgagccgg cgcacaggca aacgtgaatt acctccccaa 3307801 gctttctttg tgaaccttag tagcaaagaa cgggaaaccg ttattcgaat gagcggaaga 3307861 caatgtcttc aaccagggtg gtaccgcgtg cattgagcca cgtcccttat tgggatgggc 3307921 tcttttttgt gtttgtaaaa aaggaggaaa aatgatgaga acatttgagc agctcacagc 3307981 gtcacaacaa aaagaggtag aaagacagct tcagctatac atgacaggcg cccacgaagt 3308041 cataccgccg gaggaattaa aggcaaagct cgtgaaatca atttccacgg gcacgccgct 3308101 taaaattaag ctcggattag atccgtctgc accggatgta catttgggcc atacggttgt 3308161 gttaaataag cttcgccaat ttcaagaaaa cggccacatt gtccagctgt taattgggga 3308221 tttcacagga aaaattggtg atccgaccgg aaaatcggca gccagaaagc aactgactga 3308281 tgaagaagtt cagcacaatg ccaaaaccta ctttgagcaa ttcggaaaag tgcttgatcc 3308341 agaaaaagtc gagcttcact ataactcaaa atggctgaaa acattgaatc tagaagatgt 3308401 cattgaatta gcagggaaaa taacggtagc ccgcctgatg gagcgcgacg actttgaaga 3308461 acgcatcgcc atgcaaaaac caatctcact gcatgaattc ttttacccat tgatgcaggg 3308521 ctatgattct gtcgttctcg aaagtgatat tgaattaggc ggaacggatc agcatttcaa 3308581 tgtcctcatg ggacggcatt tccaagaacg atacaacaaa gaaaaacaag tcgtcatcct 3308641 tatgccgctc ttggaaggct tggatggcgt cgagaaaatg tcgaagtcga aacacaacta 3308701 cattggcatt aacgaacatc caaacgacat gtacggaaaa acgatgtcac tgcccgacag 3308761 cctgatgaaa aagtacatcc acttggcgac agacttagag cttgaagaga aaaaacagct 3308821 cgtaaaagac ttagaaaccg gcgccgttca tccgcgtgat gccaaaatgc ttttagccag 3308881 aacaatcgtc cgaatgtatc acggagagaa agcagcagaa gctgccgaac actcgtttaa 3308941 aacagtcttt caggaaaaca gcctgccgga agatataccg gccgtaaact ggaaaggcga 3309001 aaaaacgata gcgatgattg atctgctcgt caagctaaag ctcctctctt cgaagagcga 3309061 ggcgcgccgc atgattcaaa acggaggtgt acgcatcgac ggagagaaag taacagatgt 3309121 tcacgccaaa gcagagataa gagagaatat gatcatccaa gtcggcaaac gcaagttttt 3309181 aaagctccaa taatctgata ttccgaaacg cttatgaccc ttcattcata agcgtttttt 3309241 tgcaggtata aagcactgtc ttttcaaaaa cgctctccat cttgcaggaa actcctttag 3309301 catcccgaaa tattccccaa ccatacattt aggggaggtt tatttttgat gaaaaagctt 3309361 ttgactgtca tgacgatggc tgttttaact gccggcacac tgctcttgcc ggcacagagt 3309421 gtcacccctg ccgcgcacgc tgtacaaata tcaaatagcg agcgcgagct tccattcaaa 3309481 gcaaaacatg cgtactctac catttctcag ctaagtgaag caatcggccc cagaatagcc 3309541 ggaactgcag ctgaaaaaaa gagtgcccta ttgatcgcct catcaatgag aaaattaaag 3309601 cttgatgtga aggttcaacg attcaacatt cctgaccggc ttgagggtac actgtcttca 3309661 gcaggacgcg atattcttct ccaagcggcg tcgggctcag ctccgactga ggaacaaggg 3309721 ctgacggccc cgctttacaa tgcgggattg ggctatcaaa aggactttac cgctgacgcc 3309781 aagggcaaaa tcgccttgat ttccagagga gacctgactt attacgagaa agccaaaaat 3309841 gccgaagccg ccggagcgaa agctgtcatc atttataaca acaaagaaag cctcgtgcct 3309901 atgacgccaa acctgtcggg aaataaagtc ggcattccgg tcgtcggcat taagaaagaa 3309961 gacggcgaag cacttaccca gcaaaaagaa gccaccttaa aactaaaagc attcacaaac 3310021 caaacctccc agaatatcat cggaatcaaa aaaccaaaga acatcaaaca tccagacatt 3310081 gtgtacgtga ccgcccatta cgacagtgtt cctttttcgc ccggagcaaa tgacaacggc 3310141 tcaggtacct ctgttatgct ggagatggcg cgtgtcttaa aaagcgttcc atctgataaa 3310201 gaaatccgct ttatcgcttt cggcgccgaa gagctcggcc tgctcggctc ctctcactat 3310261 gtagatcatc tatcggaaaa agagctgaaa cgaagcgaag tgaacttcaa cttagatatg 3310321 gtaggcacaa gctgggaaaa agcgtctgag ctgtatgtca acacattgga tggccaatct 3310381 aactatgttt gggaatccag ccgtacggct gctgaaaaaa ttgggtttga cagcctgtct 3310441 ctgacacagg gaggatcatc tgatcatgtg ccattccacg aagccggcat tgattccgct 3310501 aactttattt ggggagaccc ggaaacagaa gaagttgagc cgtggtatca tacccctgaa 3310561 gactcgatcg aacatatcag caaagaacgc ctccagcaag caggcgatct tgtgacagcc 3310621 gctgtctatg aggctgtgaa aaaagagaag aaaccgaaaa ccattaagaa acaaatgaag 3310681 gcgaaagcat ctgacatttt tgaagatatc aaataaaaaa agacggcact tgggtgccgt 3310741 cttttttaat ccacttcttt cttaatcccc agcattttct catctaggta atgggcaatc 3310801 tccgcggctt ctttcagctc atctgttaat tgcttaggaa cgtcattgtt caatttataa 3310861 taaattttat gttcaaggct cgcccagaaa tccatcgcga ttgtccggat ttgaatttct 3310921 gctttgacgt attccacacg gttcgttaaa ttcacaggca tctcaatgat taaatgcagg 3310981 cttcgatagc cattcggttt gggtgtctgg atataatcct ttacctttac gattctcaaa 3311041 tcttcatgct gcttcaacac attcacgaca ttataaatgt cagaaataaa ggaacagatg 3311101 atgcgcacgc cggcaatgtc gtgaatatgc tccttcattt ccttcgtcgt aatctcacag 3311161 ccctttctca ttaacttatt cacgatgctt tcaaagcttt ttacacggga ttttgtatgt 3311221 tcaatcgggt tgtgtccgtg aatgaggtta tattcctggc tgataattga gaactttgta 3311281 tcgagcgcat ctagcgcaaa tttataaact aataactcat ttttccaatc ttccattact 3311341 gtttttaaat cgtccatatg tgttacagat aaatccatgt tcgtcatctc ctttaacgga 3311401 actttatccg ctgtccatgt actagacgtc cctgtctgct gcaaggttct atgaattttt 3311461 ttacaaaatg cggtcgattg taacaaaaaa agaccgcatg aaacgagcgg tcttttttat 3311521 tatcggaaat agctgatcaa taatccgatc gagagcagga atccgaaaaa tgtatttgtt 3311581 tgggctgttg atttcattgc gacaatcata ttcatcggca tttcgttctg gacgaagccc 3311641 ttcactgcct gaaccggctt aggcacgctc aaaaagacga caaacagcca tgggcttgcg 3311701 gcaccggtaa taaccaagcc gacaacccag atataagcga cggcaaacga cgcagctaac 3311761 agagtaacag ctcccttatg ccccatcaaa atcgccaatg ttttgcgtcc gccttttttg 3311821 tcctcttcaa tatcacgaat gttgttcgac aggttaatcg cgccgacaag aatcgcaatc 3311881 gggatggaaa tcaaaatgct ctgcatattg atcttatctg tctgaatgaa aaacgaaatc 3311941 agcacaaaca ccgaacccat gcaaatgcct gagaataatt caccgaacgg cgtgtacgca 3312001 atcggcagcg gcccgcctgt atacaggtag ccgatcgcca tgccgacaag gccgatcagc 3312061 gcaagccacc agctgctgct ggcacaaata tagacaccga gcaaaatggc aatcccgtat 3312121 gaggcaagag ctaattgcaa aatcgtttta ggcttcattc cgtggcgtac aatggcccct 3312181 ccgattccga ctgattctgc tgtatctaat ccgcgtttaa aatcatagta ttcattaaat 3312241 aagttcgtcg cgatctggat ccataggcaa gaaaacagca tagccaaaaa cagcagcaga 3312301 tcaaccttca cataaaacat cgccaaaacg gttccgagca gcacaggcac aaacgatgcg 3312361 gttaacgtat gaggacgggt taactgccaa aggatctgcc ccatgctttc tttttgcggc 3312421 gctgtctgac cctcaccctt atttgtttgg ttcatcttcc tcttcctttc tattaaaagg 3312481 cttacttttt ttcagccggc agcttaataa aaaactcctt ttgcttcctt atctatcata 3312541 atgacttctc ccttatttca caagataccg caagaaggcg ttttctttct tattatacgc 3312601 ttctcgccct gatttcatta ggtttctgct ttcacttgaa cgaacaggta cagaaaaatt 3312661 tttttaagta cattacactt tttaaaagtt aaaaagatct tttgactcca ggtatctttt 3312721 cctttattat gaatcagctc gaaacattcc attcttgccc ttgcaggtat aaagattcat 3312781 tttcaaaaac atacgccgat atattaattt gagggagatt agggaaaaaa tgaaactttt 3312841 tgagcatctg atcgtcaaat aatcatgtga ttgtcgaaaa aacgggaagg gaatttttga 3312901 tatgctgcaa ttaatgaaac agctgtatga aaaacccgct gtcaagtgga catgtcatac 3312961 aggcttttat ttgatgatac tgcttgtttt gttttttatg tatggttttc acaccgcgaa 3313021 taccggttca tatatttata acgatttcta attggagaga gaataactat gaaactttta 3313081 catgctattc aaacacatgc ggaaacttat ccgcaaaccg atgccttccg ctctcaaggc 3313141 cagtcgctca cgtatcagga attatgggag cagtctgacc gcgcggctgc cgcgatccaa 3313201 aaacgcattt ctggggaaaa gaaatctcct atccttgtgt acggccacat ggagccgcac 3313261 atgatcgttt ccttcttggg aagtgtcaaa gcgggacatc cttatattcc ggttgacctg 3313321 tctattccgt ccgaacggat tgcgaaaatt atcgaaagct ctggagcaga attgctgatc 3313381 catgcagcag gactctcaat tgatgcagtc ggccagcaga ttcagacagt ttctgcggaa 3313441 gaactgctgg aaaacgaagg cggctctgtc agccaagatc aatgggtcaa agaacacgaa 3313501 acgttttata tcatttacac ttccgggagc acaggaaatc cgaaaggcgt gcagatttcc 3313561 gctgcgaacc ttcaaagctt cacagactgg atttgtgcag actttccagt cagcggagga 3313621 aaaatatttt taaaccaagc gccgttctca tttgatttgt ctgtcatgga cctatatccg 3313681 tgccttcaat caggcgggac tttacattgc gtgacaaagg atgctgtgaa taagccgaaa 3313741 gtcttatttg aagagctgaa gaagtccggg ctgaatgtgt ggacatcaac accttccttt 3313801 gtgcaaatgt gcctgatgga tccgggtttt tcacaggatc tgctgcctca tgcggacaca 3313861 tttatgtttt gcggagaggt tcttccggtt tctgtggcca aagcgctgct tgagcgtttt 3313921 ccgaaagcga agatttttaa tacgtacggc ccgactgaag cgacagtggc tgtcacatcg 3313981 gttgaaatta cgaatgacgt catcagccgc agcgaatcgc ttccagtggg cttcgccaaa 3314041 ccagatatga acattttcat tatggatgaa gagggacagc cgcttcctga gggagaaaaa 3314101 ggagaaatcg tcattgcagg gccgagtgta agccgaggct accttggtga gccagagctg 3314161 acggaaaaag cgtttttctc tcatgaaggc cagtgggcat accgaactgg cgatgccggc 3314221 tttattcaag acggtcagat tttctgccaa ggacgtttgg attttcagat taaacttcac 3314281 ggctatcgaa tggagctgga ggaaatcgag ttccatgtca gacagtcaca gtacgttcgt 3314341 tctgctgtcg tgattcctta tcagccaaac ggaacagttg agtatctgat cgctgctatt 3314401 gtgcctgagg agcatgagtt cgagaaggaa ttccagctga caagcgctat taaaaaagag 3314461 cttgccgctt ctcttccggc atatatgatc ccgagaaaat ttatctatca ggatcacatt 3314521 caaatgacgg ctaacggcaa aattgaccga aaacgcattg gcgaagaggt tcttgtatga 3314581 cgccttacag ctcgttttta ttctttatac tgcttggcat tcttcttctg ccgacgatca 3314641 ttctcggctt aaacggaaaa agatttcaag catacaacat gttcatatct atcattatat 3314701 tggctttaat tttttcgcac gacttacacg gggtcatcgc gctgtgcctg tttacaatat 3314761 ggcaggtgct cctgatcagc ggctatctgg cataccggca gaaagcgaac agcggctttg 3314821 tcttttgcgg agctgttatc gcgtctattc tgcctttatt tctgtcaaaa atatggccgt 3314881 ttctttcaca cccgcagccg catcatccgc cgcataacct gatcagcttt ttagggattt 3314941 catatttaac ctttaaaggc gttcagctga ttatggaagc aagagacgga ctgctgaaag 3315001 aacagctgcc attgcaccgt ctgctgtatt tcatcctgtt tttcccgacg atttcctccg 3315061 gcccgatcga cagataccgc cggttcgtca aggatgaaca gaaggcttgg acgaaagaag 3315121 aatacgccga cctgctgtat acgggaatcc ataaaatctt catcggtttc ctgtataaat 3315181 ttattatcgg ctacgcgatc aatacgtact tcatcatgaa tcttcccgca atcacgcaca 3315241 ataagattct tgggaacctg ctgtacatgt acggctacag catgtattta ttctttgatt 3315301 tcgccggcta cacgatgttt gccgtcgggg tcagctacat tatgggcatt aaatcaccag 3315361 aaaactttaa taaaccgttt atcagtaaaa atattaaaga tttctggaat cgctggcata 3315421 tgtctctgtc attttggttc agagattatg tgtttatgag attcgtattt tggatgacta 3315481 agaaaaagtg gatcaaaaac cgtatggccg tctcaaacat cgggtatttc ctgctgttta 3315541 tgctgatggg ggtttggcac gggctcgcgc cgcaatatat catttacggc ctctatcacg 3315601 ccgttctgat gacgtgttac aactttttcg agaagtggaa taagaaatat aaatggctgc 3315661 cgtccaaccg ctggacaacc attctcgcta ttgtgatcac attccatttc gtttgcttcg 3315721 ggttttatat tttctcagga aaaccatttc atcaccacca ttaaaggaga ttagaaagct 3315781 atggatttta aacaagaggt attagacgtt ttagcagagg tttgccagga tgacatcgta 3315841 aaggaaaatc ctgatattga aatttttgaa gaaggtttgc ttgattcttt tggaacagta 3315901 gaattgctgc ttgcgattga aaaccgtttt gatattttag tgccgatcac tgaatttgac 3315961 cgggacgttt ggaatacacc taacaacatt gtaaatcagc tgtctgagtt gaaataatga 3316021 aaaagcgttt tttcggtcca attattttgg cgtttattct attcgcaggc gccatcgcaa 3316081 ttccatcttc atggctgaca ggcttcatca ccgataagcg tgtgaaagag tcagcaacag 3316141 ccttgaatcc gagtatgttt caagggctat atttacaaga tcagatgctc aaagatccga 3316201 catatcttcc gatttacggg tcttctgagc tttctcggct ggacgagttc cacccatcta 3316261 attattttca ggtaaacaat gagggattca cgccatacct tgtcggcaaa ggcggatccc 3316321 agtcattgat tcattcttta aacttcgctg cccacatgga tcagctgaag ggcaaaaaaa 3316381 tcgtattcat cgtgtctccg caatggttta ttaagcgcgg gtctgatgaa cagcatttcg 3316441 cgccgaacta ttctgcgctg caagggcttg atttggcatt taacgatcag atcgatcctg 3316501 aaattaaaaa gaaaatgatg aaacgcatgc ttcgctttaa ggctgtgcaa aacgatgcca 3316561 ttctttctga gctgtacaaa gcaatggtaa acggtcagac gtggaaagtg aacgcgctga 3316621 agccggcggc gaaagtgtat tacagcatgc tggaaaagaa agatctgtat tattcaacga 3316681 cagaatcatc cgggccaaag cgctatatct cgcagtcagt aaaggataag tcatggtctg 3316741 aattgaataa actagcggat caatcgggca aacgccactc cggttctaac gattttcaca 3316801 tcgacaaccc tgtctataaa aagctgaagc cgaaagtgcc taagctgaaa gggaaaaaca 3316861 aaggaagatc gtatgcggtg tcaccggaat atggcgactt tgaaatgatg ctcgatatcc 3316921 tgaaggatgc gggcgcagag cctatgtttg tcaccattcc tgttaacggg aaatggtacg 3316981 attacacggg cttcccgaaa aaaggacgca ctgactatta caaaaaggta aataaacaaa 3317041 tcagagcgaa gggcttccag gttgctgatt tctcagggca tgaatatgac ccgtatttca 3317101 tgaaagacac cattcacatc ggctggaaag gctgggtgta tgtcgataaa gcaattgacg 3317161 aattttataa aaccggaaaa gtcacttcat cctgagcatc tcataggacg cggctgcata 3317221 tttcctgcta agatttgtaa tagtaaagga atcacagcca acttaattaa gaggtgttac 3317281 atccaatgaa gatgacaaat aatacggttt taatcacagg gggttctgct ggcatcgggc 3317341 ttgaactggc caagcgcctg ctggaacttg gcaatgaagt tatcatttgc ggacgcagcg 3317401 aagcacgtct tgcagaagcg aagcagcagc tcccaaacat ccatacaaag caatgtgatg 3317461 ttgcagaccg ttcgcagcgg gaagcattgt atgaatgggc tttaaaggaa tatccgaact 3317521 tgaatgttct cgtcaacaac gccggcattc aaaaggaaat tgactttaaa aaagggacag 3317581 aggagctttt tgtggacggt gatgaaattg aacttaattt ccaagcgcct gtccatttat 3317641 ccgccctttt cacacctcat ttgatgaagc agcccgaggc ggcaatcgtt caggtcacat 3317701 ccgggcttgc gtttaacccg ttagctgttt atccggtgta ctgcgcaaca aaagcggcac 3317761 ttcactcgtt ctcgcttacg ctcagacacc agctccgcga cacgagcgtg gaagtgattg 3317821 aaatggcacc gcctatggtg gacacgggct taaaccaaaa atcacgcgat aaacaaggcc 3317881 tgacgtaccg gggcatttca tctgaagaat atgttcaata tttcttggac ggcttgaagg 3317941 aaggcaaaca ggagattaca aatgaacgtg ttgaaggtct tcgggatgcc actcgcgccg 3318001 attatgacag gttattcgag caaatgaaca cgcaggagaa ttaatttctc ctgctttttt 3318061 catatgaatt tcttacaaat ttgagcaaac ctattgcgat tatttgttga aggtatacaa 3318121 tagaatataa ttattttcaa ataagtttga taatataaac aatttaacag cagggagatt 3318181 gaccatgact aaacaaacaa ttcgcgttga attgacatca acaaaaaaac cgaaaccaga 3318241 cccaaatcag ctttcgttcg gaagagtgtt tacagaccac atgtttgtaa tggactatgc 3318301 cgcagataaa ggttggtacg atccaagaat cattccttat caacccttat caatggatcc 3318361 ggctgcaatg gtctatcact acggccaaac cgtgtttgaa gggttaaagg cttacgtgtc 3318421 agaggatgac catgttctgc ttttcagacc ggaaaaaaat atggaacgcc tgaatcaatc 3318481 aaacgaccgc ctctgcatcc cgcaaattga tgaagaacag gttcttgaag gcttaaagca 3318541 gcttgtcgca attgataaag actggattcc aaatgcggag ggcacgtccc tttacatccg 3318601 tccgttcatc atcgcaaccg agcctttcct tggtgttgcg gcatctcata cgtataagct 3318661 cttgatcatt ctttctccgg tcggctctta ttacaaagaa ggcattaagc cggtcaaaat 3318721 cgctgttgaa agtgaatttg tccgtgcggt aaaaggcgga acaggaaatg ccaaaaccgc 3318781 aggaaactat gcttcaagct taaaagcgca gcaggtagcc gaagagaaag gattttctca 3318841 agtactctgg ctggacggca ttgagaagaa atacatcgaa gaagtcggaa gcatgaacat 3318901 cttcttcaaa atcaacggtg aaatcgtaac accgatgctg aacgggagca tcctggaagg 3318961 cattacgcgc aattcagtca tcgccttgct taagcattgg ggccttcaag tttcagaacg 3319021 aaaaattgcg atcgatgagg tcatccaagc ccataaagac ggcatcctgg aagaagcctt 3319081 cggaacaggt acagcagctg ttatttcccc agtcggcgag ctgatctggc aggatgaaac 3319141 actttcgatc aacaacggtg aaacaggaga aatcgcaaaa aaactatatg acacgattac 3319201 aggcattcaa aaaggcgctg tcgcagacga attcggatgg acgaccgaag tcgcagcgct 3319261 gactgaaagc aagtaagaaa aaagccggcc cattacaggc cggctttttt tacgcttcaa 3319321 ttttgttgaa aaactgcggc agatacgctt tgtgcgcctc tagcatttcg tctaaaatct 3319381 gtttggccac agtatcggac gggacaagcg ggttaatcgt catggcaagg agcgcagttt 3319441 gatagtcacc tgtaactgcc gcttctgccg cgacacgttc aaaggatttg atttgctgga 3319501 caaggccgcg gacagacacc ggcaagtcgc cgacagcaat tggcttaggg ccggttttcg 3319561 tcatcacaca gttcacttca actgcggaat cgtctggaat actcgctatt gcaccattat 3319621 tgatcgtgtt caccggctga atgtcatgtt tatcattata aatggagctg attaagttac 3319681 atgctgcatc actgtagtaa gctccgcccc gtttttccag ctgcggcggt ttgatcgcaa 3319741 ggtttggatc tttataaagc tcgaacagct ctttttcgac cttctgtacg acttcagcgc 3319801 gggtgccctc cgtttgtgat gcttccagtt cgtgctccag catctctttt gttttaaaat 3319861 agtaacggtg atagccgcaa gggatgacat tgagcgcttt taagaaatcc ggttcccatt 3319921 cggcgcctga gatatttttc atcgtcatcg cgtttttcgg gtcgcccatc gcctcgatga 3319981 cttgctcctt cacacttacg ccgtccaaga aaacatccag cccgaatacc atatggttca 3320041 gtccggcaaa ttggacttct acgcggtcca catctacatc aagcgctttg gctacgccca 3320101 ttttgatgcc gattggaaca ttgcaaagac cgacgacttt cttcaggttg gagtagcgaa 3320161 gcaaggcttc tgttaccatg ccggcagggt ttgtgaagtt aacaagccaa gcgttcgggc 3320221 aaagctcttc tatgtccttt gcgatctcaa ggatgaccgg aattgtgcgc aatcctttaa 3320281 acagacctcc cgggccgttt gtttcctggc ctatcactcc gtattttagc ggaatgcgct 3320341 catcctttgc tcttgcctgc aaaagtccga cgcggaattg ggtcgtgaca aagtctgcgt 3320401 ctttcagcgc ctttctccgg tcgagcgtaa gatgaatgtc aatcgggacg ccagcttttt 3320461 caaccatccg tttggcgagt gtgccgacaa tattcagctt ttcttcgccc tcggggatat 3320521 cgacaagcca taattcacgg acaggcagct catcataccg tttaatgaac ccctccacta 3320581 gctcgggcgt atagcttgaa cctccgccaa tcgttacaat cttcaatcct tttgtcatat 3320641 gcttgctccc ctttgctcgg tgattttttc atataactca atgatctctg cagccatatc 3320701 cttcactgtc attgcattca ttaaatgatc ctgtgcatga accatcagaa gcgtcatttc 3320761 cgtcttttct ccgcccgctt cattttggat cagctctgtc tgataatgat gggcttttga 3320821 caattcttca gcagcgtctt gaagcttttt ccgcgcttct tctgcgtcac cgcttttcgc 3320881 agcggcaatg gcctccattg cggagctcct accgtttcct ccgtgaagga tgatttgaaa 3320941 aatgatttgt tccatttcct cattcacgcg attcacttcc tttctctaca gagccgcttc 3321001 tttgtcatct gttgctgcag gcgtttggac cagctccaga tcgttttctt ctttcagctt 3321061 ctgcttatcc cacattctga agaatggata gtagacaaca aaggacacgg caatattaat 3321121 ggcttgcatg accgcgcctg agacttttcc tcctgtcgcc aagtagcctg aaaagatcgg 3321181 cggcatggtc cacggcactg cgatacccgc cggtttggcg acaaggccgg tgctcattcc 3321241 gatgtacgtg agtgtcactg tgacaagcgg cgtgatgata aacggaagta agagcattgg 3321301 gttcatgacg atcggcattc cgaatataat cggttcgtta atattgaaga tggccgggcc 3321361 gaccgcaagc ttcccgagct gcttcatttg tttgcttcgg gcgcgcagga acatcgtgac 3321421 aaccagtgcc aatgtggcgc cgcttccgcc aatattgacc cagatatcga aaaattgctg 3321481 ggtgaaaatc ttaggaagct cctcaccggc ttggaatgcg atccggttgg catccattgc 3321541 gccgtaccaa atcggtgcca tgacgccgcc aacaatgttt gcaccgtgaa ggccgcaggc 3321601 ccataaaagc attttgacgg cttcggcgac aaggcttcct ccaaggcttc ctcccagaat 3321661 ggaaagcgga gtccccaata aaacgcttac aatattatga aggctttcaa acggtgtcgc 3321721 ttcaacaatc agccgggctg cccaaattag gaagatgacg gcaaagccgg ggattaacgc 3321781 gacaaatgac ttgcttaccg ccggcgggac accgtccggc attttgaaga ctaaattgcg 3321841 ctggataata aggcggtaaa tctctgtgga caccattgcg ataatcatgg cgacaaataa 3321901 gcctttgctt cccatgagcg aaagcggaat cccgccgcca accatgattt ctttcgtcgc 3321961 gccatccggc ataaacggca cttgataagg tgttgctaat aaaaatgccg caagggaaat 3322021 ggctccggcc gacaaggcat caacaccgta tttctcggcg agccggtagg caatgccgaa 3322081 cgcggcgaca agacccataa tttcaaaggt cgcgtcgact gggtaggcca gtttttcaga 3322141 ccaggagctg ccaaacgttt ttgccataaa ctcagcgtat cccgggatcg ggaggttgcc 3322201 aatgatgagg aaaaaggaac cgatgataat caggggcatc gtgaggatga taccatcacg 3322261 cagcgcctgc aaatgacgct gtcccgcaat tcttcccgct ataggcatga ccttttcttc 3322321 taagatctga ttgactttat tcacatagcc cgcccctctc tatgacacat gtccaagctg 3322381 ttcagctgat ttcagcactt ccgccccatt gcacgttcca taatggacgg tattaatgac 3322441 gtctaccgga accccctttg actctcctaa ttttttgagc tgcggaagca tgtaacggac 3322501 ttgcggaccg agaagcaata catccgcttt atcgatatga ttttgtacag aatcgcctga 3322561 aactgcccaa atggtatagt cttttccctg ttcctgcgca cttttttcca tcttgctcac 3322621 cagtaagcta gtagacatgc ctgctgcaca aacgagtaat atattcatgt aaaagacccc 3322681 ctagagtttg atcaattttg taatgtcctg ctgttgctat catcatatta tgaaatcgct 3322741 ttcataaaca ctcagggttt ttccgcaggc aacggaaaaa aggtatatac aggctgtcag 3322801 ctcagcattt tttggtcaaa cacatccgaa agctcttgat atgaacggca tttgatcagc 3322861 tggttcatcg ccgccgggtc atccaaaatg ctgccaagca gtttatacat gctttgtaaa 3322921 tccgctttgt tctccttttc gacacaaagc agacagacaa attgaactcg ctgactctcc 3322981 caatcgatcg gttttttgag cgtacaaacg gcccaaaacg ttgttttcgt ctgcggaaca 3323041 agcgggtgcg ggatggcaac aagattgcca aaacacgttg gcgacatgtc ttctctttca 3323101 aaaatggaat ctatgatttc ttcatcggca aagccgcatt cgaccacttt ctgccctaaa 3323161 aattgaatca cttcttcttt tgagcgcaga tcctcctgaa aaaaaacgag ttcttttttt 3323221 aggtagcgat tggctttttc cttttcatca ctcagaatag attctatttt tgtaaagtca 3323281 gttccgccta agatggtgtt aaccttcagt actggtacag ggagctcttt tttaatcgga 3323341 atggtgctga tgacaaaatc aattgattcg taggacattt gatcaagact ataatactca 3323401 gccgttccaa gaatatcgag ccgcttgccg aaatgggaac gcagtttttc gcgcagaagc 3323461 tgggcgcttc cggctcccga tgcgcataca atgatacagc gtttcggcgg gctttctgtt 3323521 ttttttcgtt caatcgcggc gccaaagtgg agagccaaat atccaatttc gttttcatga 3323581 atctcaatac ccgtttgttc ctttatcacg attccggcaa tgatcccggc ttcaaaagcg 3323641 agtggataat gttccttgat cgctgccagc atcggatttc gaagattcat gccgtatcgg 3323701 ttgcggctga tcgccggctt catatgcagt gccaagccga ttttcagctc tttgtcatgc 3323761 aggatgccaa gcttcagttc acgatcaaca gctttgatca tggcaagtgt cagctgatcg 3323821 gtttcctctt ctattgaaaa tgtgtcctct ccgcattgtg attgtgtcat tcgttttgtg 3323881 ccaaggagat gcatggtgat gtaggccgtc tcgtctttcg gaaacgtaac ggaaagcttt 3323941 gattccagct cttttacgat ggcttctgca gcctggtact ccttttgatg caggatatga 3324001 tccatatctt tcgggaaaag agaaacatag ttttccgttc tgatccgttt acaggcgata 3324061 gcgatatgga taatgaggtt attcagtccc atgttggaca gagggatgcg gtcgtttttc 3324121 atttttttca agatggcgga acggatgatc tcaatttctt cttttggcaa aatatcagcc 3324181 ttttcattta aaacatctat ctccgtttct ctttcatcaa caatgtactc cgccatgcag 3324241 tacctcatct gcacctcgtc cccgcgcagc ttgaagccgt aattcggacg tgtttccatg 3324301 acgatgcggt aaggcagcag acgtttcttt acttccttta aatccgtttg gagtgtagat 3324361 tttgagataa atagttcttc agcaagttca tcgagcttga gataatggtc cgccagcagc 3324421 agacgtttca taagataggc cattctctcc tccggcaata ccggcaggcc ctttttttgc 3324481 tgaaattcat cttgcagcag tgttctgaat acttgctcgt catcaatgcg gagcttgtag 3324541 ccggagcctc ttacagattg tacaaaggca ccgtggccgc ttagcacacc ttgaagttcc 3324601 tttatatcat tgcggactgt ccgcgtcgtt acgtttaatt gcgcggcaaa aaacgaactt 3324661 gtcaccgggg cttcagccgc catcagcaag cgcagaatat cacgtagtcg cccatgaagc 3324721 atgagaaaaa cctcctaact agtagatgca gggattcagt gaataggcag aaaggatgat 3324781 gaagggatgc gaaatgtata taaattctat aatggagaga atggcaagtc aatgaacatc 3324841 cggaggacta gagggaaaac tgacctataa aaaaacagcc gggatcagcc ggctgttcta 3324901 gatgcggaca tattcttttg tttagacgcc ttgcggtcct tcatgatttt tcgaacaatc 3324961 gggtaaatga ccggcgccca tttgataacg gttttgatca tctttttcaa agctccgatt 3325021 ctcccttctt ttttctcaac cattcccctg attgcctctt ccttaaacat gctaacgcga 3325081 cacgtacctg tttcccgtca cccagaaacg ccatggataa tcgcgtgcct ccccgctgtt 3325141 gtcaatgccg atgcgcgggc cggttgaaat tgcttccggt gtgtacccgc tttcgatgta 3325201 aagcggctgt tccgtgatcc agcgtccgta gtcattcatc gtgacgccaa gcgctttcgt 3325261 cagctttcct ggtccgtttg tccattccct cggactcctg cccggccttc tctcctccat 3325321 taacagctgg ccttcatgcg gctcaatcgc cctgattaat actgcttgcg ggacatcctc 3325381 ttccgccgca acgacattca gcaatgtatg ggtgtgcatc acgtatgtat atacccgccc 3325441 agcttctgca aacatgatct cagtccgctt cgtccggcgg ttgttaaagc tgtgggccgc 3325501 tctgtctcca gcccccatat aggcctctgt ttccacaata tagcctgacg ctgtgccttc 3325561 gtctgtttct tttacaagaa ggcagcccag aagcgatggg gcaagctcaa gagcggtttt 3325621 ttgataaaac gtgatgggca gcggattttt ttctctcgtc acgaatcgac ctctcctttt 3325681 accgattttt gtacattgta ccattcccga agcagatcaa aaaaaacggc tgttttaaaa 3325741 tctttccatt cagggaatat tgttaccgtt caaaaaagga gggccaacca ttgaaagatg 3325801 atcatcaaaa caagcagcac caatcaaatg cccaagggag cgaggaagcg ttttctcata 3325861 agacatccgg gaaaaacgag tcagaggata ccttaacgaa taggcagggg catcctgtta 3325921 ctgacaacca gaatgtgaga accgtcggga atagagggcc tacaacactt gagaactatg 3325981 attttctcga aaagatcagc cacttcgacc gggaacgcat cccagagcgg gttgttcatg 3326041 ccaggggagc aggtgcacat ggatattttg aagcgtacgg aagcttcgga gacgaaccga 3326101 tttcaacata cacaagggcc aagctctttc aggaaaaagg caagaaaaca ccggcatttg 3326161 tccgtttttc aactgtgaat catggaaaac actcgcctga aacattgaga gacccgcgcg 3326221 gttttgctgt aaagctatat acagaagacg gaaactggga tttggtcgga aacaacctga 3326281 aaatcttttt tatccgcgac ccgctgaaat ttccggatct tgtacacgca tttcagcctg 3326341 atccagtgac aaacatccag gatggtgaac gtatcttcga tttcatttct caatctcctg 3326401 aagcgacaca catgatcacc ttcttgtttt cgccttgggg cattccggcc aactaccggc 3326461 aaatgcaggg ttcaggcgta catgcctata aatgggtgaa tgaggagggc aaggccgttc 3326521 tcgtgaaata ccattttgaa ccgaagcagg gcatccgcaa cctgacacag aaggaagcag 3326581 aagagattca agggaaaaac tttaaccatg ccacacagga tctatatgac gcgattgaaa 3326641 atggcgatta tccagagtgg gaagtatatg ctcaaatcat gagcgatgat gagcatcctg 3326701 aactggactt tgatcctctt gatccaacaa aactgtggta taaagacgat ttcccatgga 3326761 aaccgatcgg caaattggtt ctgaacaaaa atccggaaaa ctaccatgcg gaagtggagc 3326821 aagcttcatt tggaacggga gtgcttgtcg acgggcttga tttttcagac gacaaattgc 3326881 tccaggggcg tacgtttgcc tactctgata cgcagcgcta ccgtgtaggc gcaaattacc 3326941 tgcagcttcc gatcaactcg ccgaaaaagc atgtcgccac caaccaggaa ggcgggcaaa 3327001 tgcaatatcg ggtcgataga gcagaaggac aaaacccgca cgtcaactac gagccatcca 3327061 ttatgggcgg gctgaaggaa gcgaagcaag acggaaaaga ccatacgccg catgtcgaag 3327121 gtgatgtaaa gcgtgaagcg attgacagaa caaacaactt cggacaggct ggagaaacgt 3327181 accggagatt tactgaattt gagcggaacg aattgattac gaatttggtg aatacgcttt 3327241 ctacgtgccg aaaagaaatt caggatcaaa tgattgagaa tttcacaaaa gctgatcctg 3327301 actacggaaa acgcgtagca gaagggctaa aaaaggtctc cgaaaacaac agcaacgggc 3327361 cgatcggcac aactgaaacg gaacaggctg caaagcaggc tgaacaggag agtcatccgt 3327421 ctgatccgta ttaacaacag cgaacagggc ttttttagaa gccctgtttt tttatttttc 3327481 tattgaaacg ctttcaataa ttgtgttgta cttggaagga aaggggtgga gagatacgat 3327541 ggaattacag caggacttga ttcctcagaa aaaaacaatc ggcgctttag atcacgccgt 3327601 ttttttatgc atggtatttt gtttctggtt ttcaggctat atttacgttc ctgtattcag 3327661 tctgtatttg gaggatctgc acttttcata tggcgcaatc ggcatcattc tcggcagcta 3327721 cggggtcacg caaatccttc tgcgattccc gctcggcctt ttgtcagaca tcctgttttc 3327781 cttgcgcaag caattgttaa ttgccgggtt cggcttttcc gtcctcagca gcctgctttt 3327841 tctgatgttt gattctttct tcttcgtgct ggccgcccgg cttttcgcgg gaatcactgc 3327901 ttctacgtgg gtgatggcga ccattttata cgcacattat ttcaacaatg gcaatgcatc 3327961 aaaagcaatg ggcatcatgc agttttttac cgtcatgcct cagtttgcca gcattgtgtt 3328021 ctgcgggctc gccgcagccc atttagggag gcaggttcct ttttggatgg cgctggcagc 3328081 ttctgccgca ggtctggtga tctgctgctt tattcaggat ccgtctgctc ctcccgcaaa 3328141 ccgtggcacc attcgtgtca atcagtacat caaagataca ttgcggctgc caaagctgaa 3328201 gcttttcacc atcctgtcta tgacggccca tgccgtatta tttatcacag tgtttggttt 3328261 tacgccgctt tacatgaatc agctcggaat gggcgacgcg gagctgcttt gggtgatgag 3328321 cgcctttttc ctcccacacg cagccgccac attaagcttt gtgtttctgc gctttacaag 3328381 ccgtatcgct tactccgtga tgctcattag tttcgctgtc accggggtct gtttgctata 3328441 tgttcctttt ttagctgcat tgttcacggt ttgcatcaca cacgcctgta ttgggctggc 3328501 gctcggcttc gtttttcctc tgctgctaag ccatgtcgtc gaaatcagtt ctgcccgttt 3328561 aaaaatgtca gtgatggggt tttaccaatc attttatgcg ctaggcatct tcctcgggcc 3328621 ccttcttgcc ggaaaaatcg cacagcttat cgggcttgcg ggagtttttt atggagccgg 3328681 ttctctggca tttgccgcct tttttgtgat gctcgcgcaa aaacgtaaca tgatcaatta 3328741 atagctttca taccgccgga agcgccacac agaaaacacg gccagaagca tgatgcacag 3328801 aatggagaaa gtgagtgacc atccgaaaaa atctgcccgc tctccatgaa gaaggatatg 3328861 ctccgcctgc ttgcaaatct cagccggaag ccacttcgca ccatctggaa atagtgaaac 3328921 agcaaaggaa acggctgctg tgagcccgat cccgcaagcc gcagctgctc cgacagaccg 3328981 gaatatcgta cttccggcaa ggccggcggt cacaataaat atcacccaaa gagcgtaaag 3329041 gccaaggctt gcggcaaagc ggctgaatga tgcgtcctca aacagcagcc ggacgtaata 3329101 gtaagcaagc ccgtatccag ctgcaaacga cataatgccg atcacgcttt ggatgagcca 3329161 tttactcacg atataatggg ctgccgtcac aggccgcgac ataatcagcg ctgttacccc 3329221 ttgatttctt tcattggcta cactgcccat cacgctaaag atgaccagag ccatgccaag 3329281 cgtgttgaat tgagaaagcg tgctgaccat cacttcagac ccggagggca tcgtaaaact 3329341 gattttcatg ccgtcaggaa ggttccctcc atgtgcgatg atttccggca tataataaat 3329401 ggtcagcggc tgtgtcagcc cgacgatcat catcgcaatc ggcagccaaa tcagcttgcc 3329461 gcttttccat ccttccagcc actccttctg caatagcgcc atcatcacct tcatgcgtgc 3329521 accaccttta gatagacgtc ttctagagac tccgttttct gttcaaagcg ggtgacggtc 3329581 aatccctttc ggatacagtc acttaataat gaccggccag cgtgtatatc aggcagctcg 3329641 aaaaccgctt gggacggatt cttatagaca atagctgaga cgtaaggctt ctcttcaagc 3329701 caaccttcca gcttctcttt cactgaaagg gtaaaaacgt tcgtttgctg ctgttgtttc 3329761 agctcctgta actcgccttt ccatgaaatc tcaccgtttt tcataatcac cacttgatca 3329821 cacacctgtt ctgcatcgtg caaaacatgt gtagaaaaca gaacggccat atgctttttc 3329881 agctcccgca tcatgtccag cacctcgaac cgtcctgtcg gatcaagcgc agacaccggt 3329941 tcatccaata tcaaaaactt cggtttatgg agcagtgcct gtgccagacc gagtctttgt 3330001 ttcatgcctc ctgaatagcc cccgatcctt ttgtgcgccg cttcgtgcaa accgacaaat 3330061 tccagcatct cgccgatttt ctcttggcat tttctcttcg aaaggccgga cagtctcccc 3330121 gcaaatgtca aaaattcatt tgcggtcatc cacgaataaa aagcaggata ctgcgggagg 3330181 tacccaatca aacgccgatc cagctttttc tctcctaaca gctttatggt tccagaggtt 3330241 ggcgaaagca gtccggccag catttgcaga gtcgtggttt tgccggctcc attaggtcct 3330301 aatagtgcga cacactcatt ttcattcacg tgaaaactga cattctttac agcttcatgg 3330361 tgcctgtacg atttgcataa tgattcaata gacagcatat cggcttacct ttgctttctg 3330421 ccgacggtga aaaataaaat cggcccgata atattgatac atacgatgat tgcagcccac 3330481 atccactttg gcccgttcgt ccgctcttct tttatacagc tgataagggc aaacaccgcc 3330541 aaagccagct gtaatacaat cagcggcaaa atcatttccc aagaaatatt cattgcttga 3330601 tccccctttt cttccgatcc ggcctaatga caaaaaagta ataacaaatc agaggcatcg 3330661 gtgcttgaat caatccgaca atcccccaaa cccatgccat gtgattacgt tttttcgcat 3330721 caataaataa aaagattccc tgcgccaata cgatgagaca agccgcaacc gttatgataa 3330781 tttctgtttg tgtcatccgc gtttcacctc gcattcgccg agatgccttt ttttctcagc 3330841 cgcaatcaaa atcggcagca ccgcaagcac acaaacctga agcacaataa acacagcagg 3330901 agcttgagtg aaagctaaga ttgcagcact cacaaccatc agcgcgcaga atacaaataa 3330961 aatgatctct tgaagaagtt tttttctgta ttcagctttc atttgtgaca gctggtgaag 3331021 cagttctttt tgattcggta tagagggatt ggctgtttga tcaatttttt tccattctga 3331081 ctttaaatga tcagaaagct tttctttatt catcatccca ctcctttctg atttgctgga 3331141 gccctttatg aactctggac tttacagtgc cttctttgat ttgaagcatc accccgattt 3331201 cagcgtaggt atagccgtag taatgcctta ataaaaccgg tgtgcgcagt ttagggtcca 3331261 gctttgaaaa cagatcgagc gtttcgctcc actctgcccc tttcgccgac acgtcccact 3331321 tgatcttgcg gattgtttcc tccgtaactg tctgattccg tttccattct ctctttctct 3331381 ttttctggtg atcgagatag agccgcgatg caatggagat cagccatgtg gagaattttg 3331441 aacggccctg aaagcttctt aaatggatgt accctttcag aaaggtttcc tgaacaagtt 3331501 cctcgctgag atcggggtga agggaaagct ttaacaagta tttatataag aaagaatagt 3331561 gatagtggaa aagggctgta aacgcctcgt cgtttccctc tttcgcctgc tggatcagcc 3331621 gctgttcttc ttgtgtatcc aatgaccgtg atcccccctt ttttgttttt ctgccttatg 3331681 agacgacacc ggattcaaaa gcgttcatct tttttacaat tcttttcagc cattgacaga 3331741 tcaggcttcc cggccgtttg gctgcatatc cttatttgta aaccccctta tagtctgtta 3331801 agctatgact ttatgtcgat ttcaaaaaaa catccaatat ggaggacgat gcattgaaag 3331861 tagaaaggcg aacgattgaa tatattccga atgaagaaag acatggtaaa gcgaaagatt 3331921 tatttcccgt atggttcggg gctaatatgc atatcaccac gttagtgacc ggcacgattc 3331981 ccgttgcaat gggacttaat ctgttttgga gtgttgccgc tattatttgc ggaaccttaa 3332041 tcggtgccat atttatggct tctcattccg cgcaaggccc tcagctaggc atcccgcaaa 3332101 tgattcaaag ccgtgcccaa ttcggcgtaa tcggagcgat tcttcccctc ttcttagtca 3332161 tgtttatcta ccttggtttc ttcgcaagca gcacgattct ggcggccgga accttaagca 3332221 gctttgttcc catcccggga tcatggagca ttataggctt aagtgccgta tgttttttac 3332281 tcaccatttt cggccatgat ttgattcaca aaatgcaaaa aatcctttct tggacctctt 3332341 ttgctgtatt ttttgctgca acgattctca tttttcaatt gccgattccg gcaggcagct 3332401 ggatacccgg agcgattgat ctgccaattt tcctagtggc agtcagcgca gttgcgacgt 3332461 ggcagcttgc ctacgcgccg tatgttgccg attattcaag atatctgcca gttaaaacac 3332521 cggcttcaaa aacattttgg tacagctatg caggtacatc tgtcagctcc atctggatga 3332581 tgctgctcgg cgcattgctg acaacctcac ttcctgactt tacggcaaac tcaggcagcc 3332641 agattgtcca attgttcggt cccttctcgt ttattatgct gatcattgtg ctatttgggc 3332701 aaatggcaat caatgttttt aacctgtatg gggctttcat gtccacgaca acaacgctgg 3332761 agccgtttct gaaattaaaa gtcacgccca aagtcagaat catcatgatc ctgggtgtca 3332821 cgcttgtcgg cacagtctta agcctactgg gacagagcaa ttttatggaa ctgtttttga 3332881 attttatctt tttcatcagt tatttcttaa ttccgtggac ggcaatcaat ttagtcgatt 3332941 actacttcgt ccgccacgga aagtatcaag tcaaagccat gttcgacgta aacgggcctt 3333001 atggaaaggt caattggatc accacaattg cgttcgttct gtctatcttg ctggaaattc 3333061 cgtttatcaa cacaagcttt tacatcggac cgcttgccaa aatgtttggc ggcggagaca 3333121 tcgcatggat tatcggcttg gccgtgcctt ctgtgcttta ctatgtatta atgaaaccgc 3333181 gtctgaaaaa acgggcgggg tatcaagaaa agctgtcttc tctctgaaga cagctttttt 3333241 atcattcaaa tcgtttccac acgcggggca ggatgtcaga tagctcatga gcgagcaacg 3333301 tatgagcgga gtgctcgtcc gtccagagct cggcgcacgc accatgcaaa tagaccgcgt 3333361 ttaatacggc gtgctttgga tcttcatggc agcagagcat ccccaatatc atgcccgtca 3333421 gcgtgtcacc ggttccgccc ttggcgagcg ccccgtttcc ggttggattg agccagcagt 3333481 ctccatcagg aaacgcgatg acggtttggt ttccttttaa cacaatgaca gtctgcagct 3333541 gagccgccca ttcctttgca tattccgctc tttttttctg caattcgttc acgggcaccc 3333601 ctgtcattcg gaaaaactcg cccgggtgcg gcgtgaggat gacggggccc tcccgtttcg 3333661 gatatgtgcg cttcgccagc gctccggcat ccaaaataac aggacaatca gccgtaagca 3333721 catgatcgac tgcctgctgt acgctttccg tttgcggaag gcccggtccg atggcaatgg 3333781 cccggtacgt ctcttcaagc tgagcatccg ccgccttttt ccagccgtca cgccaatagg 3333841 tcgcctcggg caaaacagga acaattagcg ggattacgtt ttctgatgta ccgatgacaa 3333901 gcttgccgag accgctccgc atggccccaa gccctgcaag cagcgctgct cccggcatgt 3333961 cgtcacttcc agccagcagc aaagccgtac cgtacgtgcc tttatggctc tccgcatctc 3334021 tttcaggaag cgtggccctt acatgctctt ccgtccaaaa tggaacattc atctctatcc 3334081 ctcctctgct ttcttttcct atttttcctg tcccttttct ttttcaaaca aaaaagacag 3334141 ccttttaggg ctgtctttta ttttacagga acatcaaggt gatacaggcg gcgatatcgt 3334201 tcgtttgccg ccagcagctc ctcatgggtt ccttccattt ctgttttgcc gttttcgaga 3334261 aatacgattt tatcggctgc ttccactccc gcgagatggt gtgtaatcca taaaatcgtt 3334321 tttcctttca gcacctcaaa caccgtttcc atcaattcac gttcggtaat aggatcgagg 3334381 ccgactgttg gctcatcgag gatgatgatc ggtgtatcct gcagcaaaat cctcgcaagt 3334441 gcgatccgct ggcgctctcc accggaaaaa cggatgccgg tttcttgtac agaggtatga 3334501 tatccgtcag gcaatgactc aatgtagtca tgcagcttga cctgctttgc ggcgcggcgc 3334561 acatcctcgt cgcttgcttc tccgtttccg agcctgatgt tgttcaaaat gcttgtatca 3334621 aacaggtgcg gtttttgatt taacacggcc accgcatccg caatctgatc ctttaacagc 3334681 gctgtctcca ctccgtttaa cgtcacagaa ccggagtccg gtttcaaggc gccttcgatt 3334741 aatgcaagcg atgttgattt cccagagccg cttcggccga gcagcgccat tttttctcct 3334801 tggcgcagcg taaaggaaaa gttgtgcagc acttggctgc tgttgtcata agaaaacgtc 3334861 acatcacgaa aggccaaggt gacatcttga agatcgagaa tttgatcccc tgattcagtt 3334921 tgtgacgcct ccggctgagg agccacattg ttcatgcgtc tgatagaatc ctgatagccc 3334981 ggcacttcgc ctaaggcatc cgaaagcggc aaaaaggctt ccgtcaacgg aaacaccact 3335041 agcacaaaag cggcaatcat cgttttagcg agctcgccgt ccgcttgctg tcccgctgtc 3335101 caaaacagca tcagcaaaat aaggccagcg acaaggcatt gcgcagcaaa gtcccgccat 3335161 cttgtaaagc gttgtttttt ccgttcaagc tcaaaccaat cacgttcctc tttttcataa 3335221 gcatcaataa aagcatgccg gcgtccgctg aacatccagt cgctgacacc catcacagca 3335281 tctgtcagac ggctgtacag cacattccgt ccgcttttca gcttcgcatt cttcgctctc 3335341 gtcacgagca aagacacaac cggaaacaat acaacaagaa caaacaaata cagcgcaagc 3335401 aatatggcaa acggccaaga gaagaagccg agcgctatca ctgacacagc atacaggagc 3335461 aaggctgaga tcgcaggaaa aatcgttttt aagaaagcat cctgcaaatg ctcaatatcc 3335521 tcagacaaaa tgccgagcat atcccccgtg cgaaaacggg aacgcagcat caaagcaccc 3335581 ggctcaagca tattgtaaag gcggacgcgc atgtcagata cgattttcaa aatgatgtga 3335641 tggccgacga gccgttccac atatcgcgac acagagcgcg caatcccaaa ggtgcgcaca 3335701 gcgacaatcg gcacataaat gagcagaatg ttttccggcc ttgtcgccgc tttagaaatc 3335761 aaaaaacctg aggtgaacat gagaaaagca gcagaaaaaa tcgtcaccgc acccaaaaag 3335821 ataaccagaa cgaacaggcg ggcattttgc ttgatatacg gcaaaatcca ttcttctttc 3335881 ttcatgctct ttcccccagt tgtgccttca cgagtttggt atacacaccg tttttctcca 3335941 gcagttcatt gtgagtccca atttccgcaa ccctgccccc gtcaagcacg ataatttcgt 3336001 ccatatcgag catccagtga aggcggtgag tcgcgagaaa gacgagctta tcctcaaata 3336061 aatccagcat cgtttctttt atttcatatt ctgtttcgat atcaagatgg gcggtcggct 3336121 catccagcag caggatcgga cggtttccca aaaaggcgcg ggccagcgcg acacgctgtg 3336181 cctggccgcc gctgagcgcc cggccgcctt ccccgatccg cccctctaat ccgtcaggaa 3336241 ggttgttcac cagctccgtc agtcccgctg aggcagcagc acgtgttgta tcctctgccg 3336301 aagcgcttgg atggtagaag cgaatgttgt tgccaagcgt atcatcaaaa atgtacggat 3336361 gctggggaat gtaaagaagg ttcttctgcc agctgccgtc ctgcaaatgg gaccggcttg 3336421 taccattaac ctcaatcatc ccgccatccg gctctaaaaa tccgccgaga atatcaatta 3336481 atgttgattt tccggcgccg cttgcaccga taatgccgat ttttttcttg cctttgaatg 3336541 agagatgaat atcagacacc gaacggccga ctgacacgcc tgacagcttc agctcatcct 3336601 gatcggacca agcttcgagc tgaagcggcg tctcttcttt aaaaccaggc tgcgacaaaa 3336661 tctcttgaat ggtttttcct gcttcctggc cgttcagcgt tgcatgataa tcattcccca 3336721 cttcccgcac cggcaaaaaa tactcaggcg ccagaataag cgccgttaaa gcagggccaa 3336781 gcaaaatatc gccgtcaatg aggcgcaggc ccagaaatac tgcgactgtc gccaccgaca 3336841 gcatcgtgaa aaaatcgagg gcgaatgatg acaaaaacgc cacccggagt gtgctcatcg 3336901 ttgccttgcg ataccgctca ctcacataga aaatattttt gctgtgtgac ttgctcaaac 3336961 ctaggaaacg caatgtctcc agcccgcgaa gagaatcaac aaaatgattg gaaagtctct 3337021 gataggattt ccactgacga tccgcttttc tctgcgcgac aaggccgagg agaatcataa 3337081 agatgatcag aatcggcata gcagcgacta aaatgatggc tgatgtccga tcctgaaaaa 3337141 acacataaat gacaactgcc gcaggcacaa tcgccatgct gaccattttc ggcagaaaca 3337201 gctccaggta gcggcggaac tggctgatgc cttccatcgc cagcgtcacc atttgccccg 3337261 tcccctcttt ctttgcaaag cgggggccta atcggaacag ctgatcaaga aaacttttcc 3337321 tcaaatctgc tcctgtccgg gcggcgtatt gatagacgat tttctgtcgc gccaccgtca 3337381 tcccgtgccg ggcgataaaa gcgatgagga aaaagccgat caccggtaaa agggaggtaa 3337441 tgcccttccc gttgaacagt ccggttacgg cctcactcag ccactctgcc tgcataataa 3337501 tggcggctgt ctgaatcaac gttaaacaag taatcaaggt gagaatccgc ttcattcctt 3337561 tatatcgaaa caggtctttt cccattaata agtcataggc tccttatggc tgacgcgctt 3337621 ccggaagaca taatagctcc agatctggct gccgatgacg aacggcaata gcgttaatgc 3337681 tgcaattgac atgactttaa gcgaataatc tccagaagaa gcgttagcta ctgttaaatc 3337741 gtatgcgcta tgaagcgagc tgaccattac acgagggaat agggaaataa agatcattcc 3337801 cacggtcagc gccagaccag cgcctgtcat cccaaatgtc cagccgtctt ttttcttacg 3337861 aataaataca gccgcgagca taaagcagat gacaatcaaa acagcgagcg gaatggtaat 3337921 ctcgccgcgg cgtgtaaaca tgtctgtctg atacgcagaa agggccgcga aggcaagaac 3337981 cgctacaaaa acaacaccca ttatcttttg cgccattttc cgggcgcggt tttgcaaatc 3338041 accaatcgta cgcagcgtga taaacattaa tccatgctgg aagcaaagaa gcgttaccgt 3338101 cacaccgcca agtatagaat atacattgat ataatcagat acatgtgcgt gaatgttcat 3338161 gtcggcatca atcggcatcc cgcggaataa tgtcgtgaac agcacaccaa gcacaaacgg 3338221 aggaattaga ctgccgaaaa aaacgaccca gtcccaaacc tttacccatt ttaaatgatc 3338281 caccttgccg cggaactcaa acgcgacccc gcggcccatt aacgcaagca gcactatgac 3338341 aaacggaatg taataaccgc tcagcatcgt tgcataccag tttgggaatg ccgcgaaaat 3338401 ggcgcctgcg ccagtcaaaa gccacacttc attcgcgtcc cagaacggcc cgatcgtgtt 3338461 gatcagcact ctgcgttcta attcattatg gccaagaaaa cgggtcgcca tgccgacccc 3338521 gaaatcaaag ccttccaaaa agaagaatcc tacaaacaat acagcaacga gtataaacca 3338581 aagatcatga agagatgcca tggtatacct cctgactaaa tggatctgtt gatacaggca 3338641 catcatgatg attatcatgc tccgcacctt ttttaatctc acggataaac aagaagacaa 3338701 gcagtgcacc aagaatcatg tacatcacac cgaatgcgat gattgagaat aacaaggaac 3338761 ccgctgttac gttaggcgac acagattgag cggttgtcat taaccccata accgtccaag 3338821 gctgacgtcc gatttctgtc ataatccagc ccgcggagtt tgcaagaaac gggaaggaaa 3338881 tcaacgcgat catgatgcgc aaataccatt tgctgttttc aagcttttta cggcggttta 3338941 accaaaggcc gcctaacgca gcaagaatca tgacaacacc tgctcctacc atgatgcgga 3339001 agctccagaa tgtcgttttc actggcggaa tgtagtcgcc ttttccgtat attttttcgt 3339061 actcagcctg aagggttttc atccctttga cacttccgct gaatttctga taagccaagt 3339121 agctcaaggc ataaggaact ttgatttcat ttgagctttt ttcatttttt gtatcgatcg 3339181 tcgcaaaagc ggtccaagca gcagggtcac cgctgtcttc ccataggcct tcactggcag 3339241 ccattttcat cggctgtgat tccatcaagt gctcagcctg catgtgtccg ctaaggccga 3339301 cgccaagacc ggcacaaaga ccgacgatca ttgcgagttt aaaagattgc ttaaagaacg 3339361 gcacttcttt tttcttcagc agtttaaaag cactcactcc ggcaataaag aaagctccag 3339421 tggcaagcgc accgaaaata acgtgcggga attcaaccca aagctgaggg tttgtaatca 3339481 acgcgccaaa atcattcatt tccgcgcggc cgtttttgat cgtaaagccg accggctcct 3339541 gcataaagga gtttgctgtt aaaatccaga aagatgacat gatcgttccg aatgatacga 3339601 gccatatgca gagcgcgtga attttcttcg gcaggcggtc ccagccaaaa atccataatc 3339661 cgataaaaat agattccatg aaaaacgcca ataatgcttc aatcgcaagc ggagcgccaa 3339721 atacatctcc gacaaaacgg gagtaatctg accagttcag tccaaactgg aattcttgca 3339781 aaatccccgt tacaacaccg actgcgaaat ttattaagaa taagtgtccc caaaactttg 3339841 ccattttgag atacagctca tttttcttta caagataaag agtctccatc aacgcaacca 3339901 taaacacaag cccgatagac atcggcacaa acaagaagtg aaacaacgtt gttgatgcaa 3339961 attgtatgcg ggctaatacc aattcactca tgctttctcc tccatttccg gttaaaactg 3340021 ttaatttgct cactacttca caaatagaac cgagactttg atcagtaatt cacaaaatag 3340081 acgaaaaaaa tattgctcaa tatttcacaa atgtgtcaaa aagtcatcca atatgatgca 3340141 agattgccag actgaccaaa tgacacaatc tctgactggt tcatattaag tactttacaa 3340201 cgattcattt caaaaataaa gcctaaaata cctaaaaagt cccgcactat gtgacggatt 3340261 tttgtctatt ttgttgctta tttatgtcgg ctgctaggat aaatgaccct ttattatcgt 3340321 acatcaacac atcgttcctt gcgaacaaaa tgcttgcccc cgccccagca ctcgagtctc 3340381 agcattccgt cttaaaccga ttttagtcag aatgcctctt ttcatttgaa ccggtaagag 3340441 gagaaaagtt gaatagtaaa tttttaatat attaataatt tcaatttttt agtatactta 3340501 acatagtgaa caatttcact gcatcaagaa taggggaggt ttttcaatgg gagagcttca 3340561 aacacacatg caattgcaaa cggatacaat tcacgaaggg gttcgaaaag agaattggtt 3340621 tgcgaaagcc atgaatataa aagtaggcat cataccgctt cctgtgtatg ccttgctgtt 3340681 tatattaatc actgtttttg ttatgcatca cgatgtaaaa agtgacattt tgacatccat 3340741 tgccgtcatg gcgtttttcg ggtttacctt tgcccaaatc ggcaaatcga taccgattgt 3340801 tcgttctatc ggcggcccgg ccatcctagc tacttttatt ccgtccgctg tcgtgtacta 3340861 tcacctgctg cctaatgata tcgtcaaatc caccacagaa tttacagaaa actcaaactt 3340921 tctatatttg tttatcgccg gtattgtcgt cggaagcatt ctcggcatga aaagagaaac 3340981 actcgtaaaa gcattcatga aaatctttat tccgcttatt gtcggttctg tcacagccgc 3341041 tattgtcgga ctggctgtcg ggacattgct cggactcgga tttcagcata ccctgctgta 3341101 cattgtcatt ccgatcatgg ctggaggagt cggagaaggc gctatcccgc tgtccatcgg 3341161 atattctgac atcatgccca tttctcaagg ggaagcgttt gcacttgttc tgccatcgat 3341221 tatgctgggc agcttgtgcg cgattattct agcgggattg ctgaaccgaa tcggaaagaa 3341281 aaaaccggaa tggacaggca acggcaaagt ggaccgctcc gaagaagagt cccctgcgct 3341341 ggaggaatct caaagcggac agcaaatgtt caacctttct ttatttgcgt caggcggtat 3341401 ccttgctgtt tctttatact tagtcggcat gctcgctcac gattttttcg gttttccggc 3341461 acccgttgcc atgctgttac tggctgttct aatcaagctg ttcagattgg tgcctgcctc 3341521 aattgaaaat ggcgcgtttg gagtgtcccg cttcttttca acagctgtga cctacccgct 3341581 tctctttgcg attggggtat ccatgacgcc gtgggacaag cttgtcgccg cttttaacct 3341641 cagcaatatt atcacgattc tgtctgtcgt tgtgaccatg atggccgttg gcttcttcac 3341701 tggaaaatgg ctgaacatgt atccgattga aaccgccatt attaatgcat gccattctgg 3341761 gcaaggcggc acgggtgacg ttgccatttt aagcgccgct gaaaggcttg agctaatgcc 3341821 tttcgcccag gtgtctaccc gcatcggggg cgcgattaca gtatccttaa ccttattgct 3341881 gctgcaccag ttttattgat ccccgcaagc aagttcttcg tcaaacgaaa gagcttgctt 3341941 ttttgcatgt ccatgttttt gcaagttccc atcccatgct atagtaatag ttggaaatac 3342001 tagatagaaa ggaatctggc atgcctatgg gaactcatct atttctcttt atgcttctcg 3342061 ggctgggatt ttatttgata tcagccctag ctgcaaaact cattccggcc atagacttct 3342121 ggattgatat tgttctatgg gtcggcgctg cggcttacat cttctctcat ctctcattca 3342181 tggacggcat tgtctcactc gcgacaatgt tctactgcta ttggaccgca atggatctca 3342241 ttgtttcaga gcgtgtggaa aaaccttcgg gagactggca ggaaatcgag cttgccaaaa 3342301 acaaaacacg cctcctgtca gacattacgc tgaccgccat tgtgtttgca ggggctgtca 3342361 tttttttcat ctatggacct gacacaagcc ctctcaaata tgtgatcctt ctcggaatga 3342421 tctccggcgg aggggcactt gtgaagcgaa tactgaatgt ttttagcgta aaggtttttt 3342481 attcagcagc cttagaaaaa ttgcatatca gctcacacta tgaaacccgt acatacccgc 3342541 tttccgattt gaagaacatt cagcttgaat caacagcaga tctcttaaag ctccatccgc 3342601 ttctgacgat gtattcatcc cgtttagatt tgacaacaag ctttcagcaa gtcattaaac 3342661 tgtctcttcc cggcgaaaca ctgtttctga cggtgaagga accgcaaaaa tggaaaacaa 3342721 ttcttcagga atacacagat gcagaaaaca atgtggacaa tgtgatttct gttttgccgt 3342781 tttatcatcg aaaaaatgtg aagcggctgc tcggtaagct ttattttgcc gccagcgtaa 3342841 aaggggtatc cgcttacgcc ttattggtgc tcgcgttata cgcattacac gcctctccat 3342901 gggtcatggc tgttgccgta atcctatatt gggtattcaa catgtatatg tcagaccgtg 3342961 tgttgcgggc ggcgatggac gccaagtctt gtcatcatcc gcatgtacag gccgcggccg 3343021 ataagatttt cagatcggcc ggcatttccc atgtccgcat atacgaaacg gagagtgatg 3343081 attacaacgg aatggcagta ggcatgaatg tcgggaggtc aatggtcatc ctgacaagcg 3343141 ccacactaac acttccacag cgtgtcattg aaggcattct ggcccatgag gcgattcata 3343201 tcaaaaaacg tgacgttctg tcatcacagc ttttgcgttt tctatatctt ggagctgtcg 3343261 tggggatttt cctcttgttt gagcagcata tcacccatcc cgaggcccac aaaattgcgc 3343321 tttgggcttt cattatggca atcattatcc tattccagct ctatcaatcc ttttgttcac 3343381 aatggatgga ggtgcgtgct gacaaccttg gcgcatcatt gctggacggc ggttacaaac 3343441 aaatggctga agccttgaga atcttggcgg ttcggcaaga tgaggatata cagaaacaaa 3343501 gtgcctatag ctctgaagca ggtgaagacg agcttcaaat tgattctctc acccgtgata 3343561 aaagctggtt tttcagattg attgattttc agttcgctcc tcatcctcct atgtattggc 3343621 gtgtcggcac tttattgtca aacaaaggac atggggtgct aaagcgctgg ctcagagacc 3343681 gactgaaaga atcgatcact ttgaaatgaa accggtcagc gtttcatccg tataacagat 3343741 atggtgaaaa aagggagtga cgcgaagtga ttgtgatcat cttattgttt atatctatta 3343801 ttgtttttct ttcagtcatt cagccgcagc cctcgaaaaa caaaagccgc cagcaggcgg 3343861 acagcgggta tttcggttat tcagatcata gctcacacca tgatggatgc agcagtgacg 3343921 gaggtttcag cgattccggc tgtggcggcg gagggggcgg cgattaaacg ccgccttttt 3343981 ttatttcatt gattcgatgt acgcaccaaa agccgagcct gacatgcctg gggacacgcg 3344041 cacacgatgg agggcataca ttccctggtc tctcgaagcc gcgcccggtt ctgtcgtcac 3344101 gcccatttga tagcctgttt tttcagcggc cttcagcgtc tcctcattgt agcgccctac 3344161 cggatagctg atgatggtgg tttgctgatg aaacatgttg tcgaacagct ttttcgaatc 3344221 agccatctca ctttgctgct gttgaggcgt taatccgttc agctcaaggt ggtcaatcgt 3344281 atggctttca atcgatatgc cgtgctgtgc catttccttc atttgttcct ctgtcagatg 3344341 gtgcttatgt ccgatcgatt tgccgatcat aaaaatcgtt gccttcatcc cgtacttttt 3344401 cagcaccgga tacgcatctt gataattgtc ggtgtacccg tcatcaaatg tgatcagcac 3344461 gcacttctca ctcggttttt tatcctgcgt cagcatgaga gatgcctctt tcggcgttaa 3344521 tgtctgatag ccgttatcat gaagccactt catatgcgcc tcgaattctt tctttggcac 3344581 acggaggctg tttcctgaag aaatgctgtg gtacatcaaa atcggcagct ttgccggttt 3344641 ctctgttttg atccatgcgg atgtatcgtc ttcttttttc tgaacttgta ctgccttttt 3344701 ttccggtttc ttttgttccg cttttggcat cggctgctct gcattcgcct cttgatcagc 3344761 acaagccgca agagccaaac agctgcccaa aagaaagatg cttaaaaaca atcgtttcat 3344821 cgttctcctg ctttctgtct atttcttcct cctttttcat cggtttgatt ctgagatttt 3344881 caatagcaaa aaaccggaca tgtctccatg tccggttttt ttgatcttat cggattctca 3344941 cttctgtctc actgtcaaag aaatggcctt tattcatatc aaatgcaacc gtcagctcat 3345001 cgcccgattg aatatcgagg cgggcgtcga tccgcgcaat aaagtcttgg ttgtctatct 3345061 gcgaataaat cataatttca gaaccgagca gctctgcaac attaattttc gccttaatcg 3345121 aagagttctt atatgattcc acgacaatca attcatcatg tatatcctca ggacggatgc 3345181 cgaagatgac ctctttgccg atgtagcctt tttcacgcag cactttcatt tttccttccg 3345241 ggacggttaa tgccgcagaa ccgattttga ttaagccatc cgtgagcttt cctttgaaaa 3345301 aattcatcgc cggtgatccg ataaacccgc cgacaaagac gttttcaggg aattcatata 3345361 catccttcgg cgtcccgatc tgctgaattt tcccatcttt catgactaca atccgtgtcg 3345421 ccattgtcag cgcttctgtc tggtcatgcg tcacataaat cgttgtagtc tgcaatctct 3345481 ggtggagctt aatgatttcc gcccgcattt gcaccctcag cttcgcgtcc aggtttgaca 3345541 aaggctcatc catcaggaac acctttgcat cccgcacgat tgcccggccc agcgcaaccc 3345601 gctgtctctg tccgcctgac agcgctttcg gtttacggtg caaatattcc tcaagcccga 3345661 gaattttagc ggcttcttcg actctttttt tgatttcagg cttcggcatt ttccgaagct 3345721 tgagcccgaa cgcgatatta tcgtagaccg tcatatgcgg ataaagcgcg tagttctgaa 3345781 ataccatcgc gatatccctg tcctttggcg ctacatcatt gacccgtttt ccttcaatat 3345841 aaaaatcacc tttcgaaatt tcttcaagtc ctgcgaccat tcgcagcgtc gttgatttcc 3345901 cgcagccgga cgggccgacg aatacgataa attccttatc ggcaatatga aggttaaagt 3345961 catcaaccgc cggttccttc tgatcataaa atttataaat gtgctccatc cgcaattcag 3346021 ccatctaaca tccccctttg ttattgtaaa cgctttctta tattgagtgt aacagcaatt 3346081 ccctctcgct aaaatgggca gcgttcataa aatcacccag ccatttttcg tgcatatttc 3346141 caatttattc tgaactttca ttttgcaggc agataaaata ggcaagaagc gcgcctttgt 3346201 acgatttgat atctatccct gaccgctcaa taaatttatc aatccgatat tgcaggctgt 3346261 tgcgatgcag atgcagcttt ttcgctgtta atgtgacgtt tgagttgttt tcaataaaca 3346321 gcttaatggt cttccttagc tcagattcac ttccaaataa aagctcagct tcttcagaga 3346381 gcagtgtttc cagtttttct ttttctgttt ctaataatag aaaaggaaag atcatctcaa 3346441 aggtcacact ctgcacctga ggcagccgtt tttcagcaaa caggaaatac gcctgttcac 3346501 gagcgtaatg ttttcgcaga cactcatccg gctcgtaaaa tcttccggcg taaaaacgga 3346561 cactgaagta gaaatcactt tcaagaacct tagcgagcga ttccagttcg tccttctccg 3346621 ccgccgcttc actttcctgc tcgacaatca cacctctgtc ctcatggatc cacacaatca 3346681 caaaagacac cggccaaaaa tggcgaaccg cttccgtaaa ggacgtcctt tctattttgc 3346741 cgaataaatg aaagtgaaca aatctcgtcc gtttctttat atacgccggc aattcccctc 3346801 tggaaaaaag gaacgaaaac cacttgtttt cctcaggtga tttcatagac agttgattgc 3346861 cctcatccgc aggcgtcaaa aatgactgca gcaccaatac ttctttttca ctgatctctg 3346921 ttttcggaat ggagatatat ctctgattgc tctcatcaaa aaaacataga cagccttccc 3346981 ttatgcaaag ctcctcagac acaatcgaac cgggataaat agccagcagc gatttcatag 3347041 agtctcctct cttatgtaag gatctgtata ttcagtataa ggcgaaacac acatgttctc 3347101 cactaaaaaa gagtatatcc ggtatagata gacgagaaac tgaaagggaa acctcattcg 3347161 tttacatatt ggcttcagcg gaaatagaag aagacatgca ggaccaaagg agggtcatct 3347221 tatgagtttc gaaacgttaa acaaaagttt tatcaacgga aaatggactg ggggagaaag 3347281 cggacgtacg gaggacattt tgaatccgta tgaccagtct gtgatcacaa cagcatcttt 3347341 ggcaacgggc aaacagcttg aggatgcgtt tgacattgca cagaaagccc aaaaagagtg 3347401 ggccaagagc acgacggaag accgaaaagc cgtgctgcaa aaagcgcgcg gctatttaca 3347461 cgaaaaccgt gatgacatca ttatgatgat cgcccgcgaa actggcggaa cgatcattaa 3347521 atcaacaatc gagctggaac aaacgattgc gattttagat gaagccatga cgtatactgg 3347581 tgaattaggc ggcgtcaaag aggtgccatc cgacattgaa gggaaaacca ataagattta 3347641 ccgccttccg ctaggtgtca tttcatcgat ttctccattt aatttcccaa tgaatctatc 3347701 catgagatcc attgcgcccg caattgcgct gggtaacagc gttgttcaca agcctgatat 3347761 ccaaactgct atttccggcg ggaccatcat tgcgaaagcg tttgaacacg ccggtcttcc 3347821 tgccggtgtc cttaacgtca tgctgacgga tgtaaaggaa atcggggacg gcatgctcac 3347881 caatccaatc ccgagattaa tcagctttac agggtcaaca gcagtcgggc gccacatcgg 3347941 tgaaatcgcc ggtcgcgcct tcaaacgaat ggcacttgag ctcggcggca acaatccatt 3348001 tgccgttctt tcagatgcgg atgtcgatcg tgctgtggat gccgcgattt tcggaaaatt 3348061 tattcaccag ggacaaatct gtatgattat caacaggatc atcgttcatc aagatgtata 3348121 cgatgagttt gtagaaaaat tcaccgcccg tgtcaaacag cttccgtacg gcgatcaaac 3348181 cgatccgaaa accgttgtcg gcccgctgat caacgagcgc caaatcgaga aagcgctgga 3348241 gatcattgag caggcaaaga cagacggcat tgagcttgcg gttgaaggaa aacgcgtcgg 3348301 aaacgtgctg acgccgtacg tctttgtcgg tgcggacaac aacagcaaaa ttgcccaaac 3348361 ggagctgttt gccccaatcg caaccattat taaagctggc agcgaccagg aagcgattga 3348421 catggcaaat gatactgaat acggcctcag ctctgcggtt ttcacttctg atttagaaaa 3348481 aggcgaaaag ttcgccctgc aaattgacag cggcatgacc catgtcaacg accagtccgt 3348541 caatgattcg ccgaatattg cctttggcgg aaacaaagca agcggtgtcg gccgtttcgg 3348601 caatccgtgg gtcgtcgagg aatttaccgt gacgaaatgg atttcgatac agaagcaata 3348661 ccgcaaatat ccgttctaaa tgaaaaaatc cctctgtttc aagtacagag ggatttttct 3348721 ttatttagat atatccacaa acccttcgcc aaacacatcg cgtacgtcat gtacgatcac 3348781 aaacgctttt ttgtcgcagc ttctaatgat ttttttcagc atagacagct cctgtttgtt 3348841 aatgacgata tacaaaatct cttttgactg gcccgtataa tttcccttcc ctgataaaat 3348901 cgtcacgccc cgatccatca aggtatttac ctgctctgca atctcactct tattttctga 3348961 aatgaccgta atggcttttt tcgtattcaa accttcaata atgaagtcca tcactttggt 3349021 accgatatac agcatcacga tcgtaaacat cattttttct gcaccaataa taaaataaga 3349081 gctaaatact acgattaaat caaaaaacaa gagtgcatag ctgatattcc agtctaaata 3349141 tttattagca attctggcca gaatcgcgga accggccgtc gtcccgccga cccggataat 3349201 catgccgatc ccgactccgg caaatacacc tgcgaaaatc gtattaatga tcaattcatc 3349261 agacggaatg ctccacccat gtgtcagatg aagaaaaagc gaatttgccg caaccgcaat 3349321 gatcgtataa accgttgttt ttccatcaag aaacttgtag ccgattaaaa gcaaaaacgc 3349381 atttaagata aagttcgtga caccaggaga ccattgaaac agataataca aaatcagcgt 3349441 aatcccagtg actccgcctt ccccaagatc attgggaatc gcaaataaat taaccgcaag 3349501 cgcgaagaaa aaagcgccaa tcacaagcat aagtacatcc agcattctct ttttcatcac 3349561 gaaaacactc cttttcattg ttctgttcta gcaaataaaa aaacccagga gaacgctctc 3349621 gaaaaagagc agaaactcct gggcttttat cccaccgtgt cataacagcc aagctgctat 3349681 gtgttttctc tcggtcacag tccaatttgc attgcggaac cctagaaaac cactgttttt 3349741 atcatatcct tttcactttc caatattagc attataaggg acggttcgaa ttggttcaag 3349801 gggtatttgc ggagttttca tcagataagc tggaaaaaaa tacgatttat ctattaaaaa 3349861 agaacagata taaccgataa gaaaaaaagc atatatttta caagcgaatg taactataaa 3349921 tgataataat tataagaaat tcataatttt atattgacta agagaaataa tataggcatt 3349981 atagtacata tgtttcgtac attttattac ataggaggaa atataatggc aggaaaacta 3350041 gtaccctgta aagcttgcgg tcaagaaatt gcaaagggtg taaaaaaatg tcctaactgc 3350101 ggtaaggatc aacgtaactt ttttatgcga cataaaatca ttacgtttat tctcgcagtt 3350161 gttgtcatca ttattatcgg taatatgatt ggcggcggag gcggctcaga agccacttcc 3350221 aaaacatcaa gcagcagcaa agcagaaact gaaaaaacat acaatatcgg tgataccgta 3350281 aaaactgaaa aaactgaagt gacggttacg aaggtagagg acagagatac tgtcggtact 3350341 caatatgttg aaaagaaagc atctgaggga ggtacaattg tagctgttca atatacaatt 3350401 aaaaacgtat ctaaaaagcc gattagctct ttttcaattc caactgttaa attagttgat 3350461 gctgatggta cttcttatga ttctgatatt gatgcttctg taaactatgc aactgagaca 3350521 aaagttgata actctaaaat tttgagtgat ctaaatccta atattaaagt aacaggtgta 3350581 aaagcatttg aagttgacaa ggaagcttat gcaaaaggca cttggaaact aaaattcagt 3350641 aatgatgtta ttgtgaaaat caaataacag ctaacaaggg tgcctgttta ggcacccttg 3350701 ttctttaaaa aaggccttct caattgagaa ggcctccatt cttattccgc actcttatac 3350761 ccattcacat tagaagactg ccatctccag gaatcagcac acatttcctc aaggccgcgt 3350821 ttcgcttccc agcctagttc tcgcttggct ttcgcaggat ctgcaaagca tgtggcgatg 3350881 tctcccggac ggcggtccgc aaaacggtat ggaacctctt tccctgacac tttttcaaag 3350941 gctttgacca tttccagcac gctgtagcct gtgcctgttc caaggttgta tgcatcggct 3351001 cctgtagagt tcaatacttt ttccagcgcc ttgacgtggc cttctgcgag atcaacgacg 3351061 tgaatataat cgcgtacgcc tgtcccgtct tttgtcggat agtcatttcc gaatacgctt 3351121 aattgctcga gcttcccgac tgctacctgt gccacatacg gcataaggtt atttgggatt 3351181 ccgttcgggt cttcaccgat ccgtccgctt ggatgcgcgc cgaacgggtt aaagtaacga 3351241 agcagcgcaa cgctccactc attgtcggct gtatgcaaat cacgcaatat ttgttcaagc 3351301 atgagcttcg tctgcccata aggatttgtc gcgcctaatg gaaagtcttc cgtaatcggc 3351361 gatgtttccg gaacgccgta tactgtcgca gatgaactga atacgatttt cttgacgccg 3351421 tatttctcca tggcctcgca taaaataaac gttcctgtca aattgttatg ataatatttg 3351481 aggggaatcg ccacagattc gccgactgct tttaaccctg caaaatgaat cacagcttcg 3351541 atttcatttt cagcaaaaac ggaatctacc gcttcccggt ccaataaatc cgcttcgtag 3351601 aacgttaaat cttttcctgt aatctccttg acacggttca gcgcttcagc tgaactgttg 3351661 gacagattat caagaacaac aatctcgtag ccgctgttca atagttcaac acatgtgtgg 3351721 ctgccaatgt aaccggcacc gccagtaaca agtattgcca tgatgtaaac cctcctaaaa 3351781 aatgacctgt tttcattata tagtgtttag aaccggtcca catccatttt taagaagttt 3351841 aatcgtttat taatagtttt ttcatatttt ttagcttaaa cccttgccag caattcgata 3351901 gaggtttcag caagaatgtg ctctttcatt tcttgataga gctcattcaa gtaaaagccc 3351961 ggctgaagat tcagctcagc atctaaagca tagaccgtca atgtatacgc atgatccttg 3352021 tcaggcggtg tcggcccgca atactggtga atcacctttg gatcgttgct tcccgcaagc 3352081 ggtgaagcaa agctgttttg cccttgtatc atcaagtcct gtctttcctc actcgcatgt 3352141 tcaggaagct ctccgatgta agccggaata ttagccgctg tccagtgaat ccagctgaat 3352201 ccgcatacgg gaatggcgtc atgatcgatg aaagtaagtg cgagcgtctt tgctccggac 3352261 gggatgtcat caaaatgaat tggaaaggat acaaatgggt ttccttctct cttatatttt 3352321 tcatccgcgt attttgaata cttgtcatgt aaatatggat ttgcttctac gtatatgttc 3352381 atatgaatcc ctctctctat tttctcgttc tataggtata ctaaacgaat cgatgtataa 3352441 tcagtgataa acaaatacgc atgtaaacgt aacaatttgt tatggataac ttgcagtgaa 3352501 ggagatattt catggattta aaatggctgc aaacctttat tgccgcagcg gaatcagaga 3352561 gcttcaggga ggcggctgag catctgtatc tcacacagcc tgccgtttct cagcatatga 3352621 ggaaattgga agatgaactg gacatgaggt tgtttttgca tagcggaaga cgagtcgtac 3352681 tgactgacga aggcaggctc tttttgcctt atgccaaaga aatgatccat gtttaccaag 3352741 ctggaaagca gaaagtcagt caatggaaac aggggtacag ccgatcactc acgctggccg 3352801 tacaccccta cattgcgtcc tatatcttgc ctcgctttct gccagcctat atccaaaaac 3352861 atccgcatgt cgagctttca actcatgtgg ctggatctga cgctattaaa caagcggtgg 3352921 aacacaatga agctgatatt ggtttgtcgc ggaaagaccc gaacaccaac actctttatt 3352981 atcagcatat atgcgaaggt acgctttgtc tggcggctcc tttccaagaa agcagaccgg 3353041 atgctgcatc cgtcttaacc cgctatcggc tgctaacgca tgatcatccg tcatatgggg 3353101 atgccttttt agataacatc cgatcacatt acccgtatct tcaaatgatg gctgtcgggc 3353161 agacggatac ggctgtccac atgatgaaag cgggaatggg ggcatctttc ctccctacct 3353221 acattatcaa acaggaagaa gccgaaaaaa agctgatggc tgtcagcacg cctgcacatc 3353281 tagaattgcc tgcgtcccaa acgtttatga tgtggaaaag aaacagcgaa gacattcagc 3353341 attttcacgc catgttacat gactttatgc agcgcgaaca agtatagagc tgaaaaatca 3353401 atctgccggt tgacgttttt ctttcctatt ttcgctatgc ttaatgcaga aaggatttga 3353461 tgacatggcg atgagccctt atatttttat tgtattgatt cttattattt tatcgatgta 3353521 tcgagaaaga acggtaaagc ccgggaagtt gctgatcatt ccactgttgc tcttatgggg 3353581 cgtatctgca tcgtttcagc cggcgtattt tcattccgta ttacatgtgg cgatcagcgg 3353641 cattttatta ctgatcgggc tggcctgcgg gtttggcatt gggaagatgg taaatgtacg 3353701 gattcacccg gaaaccggaa aggtcacttc acgcggctca cttgggagtg ttatcctcat 3353761 tctagtgata ctttctttgc gcatggccgc gagaacatgg ctgcctgaga gcaacgagat 3353821 gtttattgcc attattcatt ctatgttctt cgttcccctc ggcaccatca cagcccgcaa 3353881 catcatgctt tacaaagcat acagacgact gaccgctggc aaagtatcca ttcaataacc 3353941 gaaagaagga ccagcatgaa cggacaaact ccggctcggc actactacaa gaagcttgtg 3354001 ccgagcctta ttctcatttt gaattgcata caatttttat ctcatccaac taaggctgat 3354061 cccattttgt tagcatttgt atttgcggta tacttagcat tcatttggat cattccctat 3354121 gtggcatcca ctgctgttag tttgagcata ttcatcggac tctggctcct gaccgatttc 3354181 ttttgggctg tttccggcca agagcagggt gccgcctatt ttttgattgt atttttaatg 3354241 atatatgccg cctttagact cccttcacgg ctatccttga tcttcacagc atgtttaatt 3354301 ggaggcaaca tattactcct atcctcacaa gggggaagct tgaataccat catcagcaac 3354361 atctcgatca tgctcggtct gtacgtcctc ttctcctcca tgcgtttcag acgagaagcg 3354421 agaagggagg ctgaacggaa tcatgctgaa ttggcaaaaa tgcatgtgca gctggagcat 3354481 gctcataaag aactccagaa agcgcatgca gagctgcagg aggcttctgt tctttcatta 3354541 aggtacgcgg tccttgagga acgtacaaga attgcccgcg acattcatga cagcatcggt 3354601 cacgagctga cttctgtgat tgttcagctt caatcccttc cctatatcct taaaagcagc 3354661 aaggaggatt cagaaaaagt cattcaaaat gtactgagtg tcgccaggga gtgtcttcaa 3354721 gaagtgcggt ctgttgttca ccaaatgggc cgtagtgaat cgatggtggg gcttaccgct 3354781 ttgcgggggc tcattcatca agtggaggaa cggagcggct tgcacgtttc tttagatact 3354841 gccggactgt cagaagagtc ttggcctcca aacgtgagcg aaacgatcta ccgcatcttg 3354901 caggaagcgc tgaccaatat cattcgtcac gctgacgctt ctcatgcggc ggccgtcatt 3354961 tctaatgaca agtcccatct ctatgtcaca atcaccgacg acggacaatt caccggcagc 3355021 cttacttatg gatttggcct gacaggaatg aaagagcgcg cagaaaaagc aggcggttcc 3355081 cttactttca gtgccgtaca gccgagcggc ctgaaaattg agctgtcatt gccgctcatg 3355141 acaacgaata aggagcaaaa agatgaacaa agataaaata cgcgtagcgc ttgccgatga 3355201 tcagccgctt gtgcgtgaag gcttccgcta cgtcatcaac gcacagacgg atatgacggt 3355261 ttctggcgag gccggcgacg gtcacgatat tatagcactc gcaaaacaaa caaaacccga 3355321 tgtcatcctc atggatgtcc agatgccgcg ttgctcaggc atcgaagcgg cgaaagacat 3355381 tatgtccgca cttccaaata caaagatagt cattttaacc acctttgaca cggaagaata 3355441 cgtatttgaa ggcatccgtg cgggcgcagt cggctatctg ctgaaggata cacttcctga 3355501 ggagttgata gatgcgattc gcgctgcggc cagaggcgag gcgattttcc gtacagtcac 3355561 agctgctaaa atcatcagtg agacatttcg ggcgaaacag caaactcatg ccgaagaact 3355621 ggcagagccg ttcaccaaaa gagagcttga ggttcttcag caaatggcct acggactgag 3355681 aaatgaggat attgctgaaa agcttttcgt cagtgaaagc actgtgaaaa cccacgtgca 3355741 ccgcatcctg caaaaatgca atgcccaaga ccggacacag gcagtcgttt ttgccattcg 3355801 aaacggtatt gtgcaataga aatctctcat cccgccatgc taaaataaga caaaggagat 3355861 gattggaaat gaaagaagaa atcattgaac ggtttactac atatgtaaaa gtcgatacac 3355921 agtccgatga atccgttgac acttgtcctt ccacacccgg ccaattgaca ttaggaaaca 3355981 tgctagttga tgaattgaag tccatcggca tgcaggatgc agccattgat gaaaacggct 3356041 atgtcatggc aactcttccc tccaatactg aaaaagacgt gccgacaatc ggctttctcg 3356101 ctcacgtcga caccgctaca gactttaccg gcaaaaatgt gaatccgcaa atcatcgaaa 3356161 gctatgatgg aaaagacatc gttcttaacg aacagctgca ggtcaccctg tcacctgatc 3356221 aattccctga gctgtccggc tataagggcc atacactcat caccacagac ggcaccaccc 3356281 ttctcggcgc agacaataag gccggtatcg ctgaaatcat gacagccatg gattacctca 3356341 tcaaacaccc tgaaatcaag cacggcacaa tcagagtcgc ctttacgcct gatgaagaaa 3356401 tcggaagagg gccgcacaaa tttgatgtga aacggttcaa tgcatccttt gcctacacgg 3356461 ttgacggcgg gccgctcggc gagcttgaat atgaaagctt caatgccgct gccgcaaaaa 3356521 ttacgattaa aggcaacaac gtacatcccg gaacagctaa aggaaaaatg atcaactctg 3356581 cgaaaatcgc gatgaagctg aacagcctgc tgccggcaga cgaagcgcct gaatatacgg 3356641 aaggttatga aggcttctac cacctgctgt cgattcaagg agacgtagag gaaacaaagc 3356701 tccactacat tatcagagac tttgacaaag agaatttcca aaacagaaaa gaaacaatga 3356761 agcgtgccgt tgaagaactt caaaacgaat acgggcaaga ccggattctg ctggatatga 3356821 acgaccaata ctacaacatg agagagaaaa ttgaacctgt catcgaaatc gtcaacattg 3356881 ccaagcaagc gatggaaaac ctcggcatcg aaccgaagat ttcccccatc cgcggcggaa 3356941 ccgacggatc acagctgtcc tacatggggc ttccgacgcc aaacatcttt acaggcgggg 3357001 aaaacttcca cggcaaattt gaatacatct cagttgacaa catggtcaaa gccgtaaatg 3357061 tcatcgttga gattgcaaag cagtttgaag cgcaagcata acgccaaaag ccagtccaaa 3357121 aaaggactgg cttttttgtg tgaaaatgaa acattttaaa cacgtcctcc gtaaaacaag 3357181 tatcaacaaa tgaggaggaa aaacaatgac aaaacatgca atcgctgcca agagtctctt 3357241 gaaaaaatgg atcatttcca ggccgcttaa catgaaaaag aaatccagcc catttcaaaa 3357301 aatcagaaaa atgttcaaac gcttcttcaa ataaaacatc aaatccccta aatacaatcc 3357361 gtattcaccc gtaccgccca aatgctccgt aatttgggtt ttttgtgttc aattccgcaa 3357421 aatagggtat aaaccaaaca agcaagaaaa cagcacccaa aaacaggtaa ttcgaattac 3357481 gtaaacttag gttaaaagtt atataaagga atttatttta tcgtcgatag taactataga 3357541 accaatcatc aacaagagca aacagcgtaa ttcaagacta ttttcaggtc atcaggtaat 3357601 actgttttag agggacagtt tcttgttatt tattgattta gaattttttg aatacttttt 3357661 ggcattttat ccgtacaata gagagtacca aaactttttt tgggaggtat gtaatatgat 3357721 cctatttatt atcatcgcat tatgcggcta tcttcttttt tctttcagca aggacaatcg 3357781 ccgcaaaccg caaaagacaa gccctctgcc agcagccgca cctcatcaca acaacctaat 3357841 cgaccttgac gccatccgcc aaaaacgccg gatgcatctt tcctaattct atatttcaaa 3357901 cgaaaaggct gctgaatcac gcagcctttt aaaattgttt tgatttagag cctgaaacct 3357961 tttcgccacc tatccgtaat ttcatacaag gcaaacccaa aggagacttc agcaatgatc 3358021 gagttattta tgaaacaaaa aatgttctca tttaaagatg catttcacat ttatgaccgg 3358081 gatgaacaag aaacattcaa ggtggagggg cgttttttct cgttaggaga ctcattacaa 3358141 atgacagact catctgggaa aacgctcgtt tccatagaac aaaaactaat gtctttattg 3358201 ccgcgctatg agatttcaat tggcgggaaa acagtttgtg aggtaacgaa gaaagtaacg 3358261 ttttccaaac cgaaatttgt gatttccggg cttaactggg aaatagatgg tgatttatgg 3358321 agggatgaat tccaactgac ggacggggaa aatgtccgga tgtcagtgag caaaaagtgg 3358381 ctcagttggg gtgattccta tcacttgcag attgcatacg aggaagatgt tctgatttgc 3358441 actgccatcg ctatcgtgct tgatatggtt ttatataacg atgaagatga aagtattttc 3358501 taaaaagcat tgacaattga tccaaaagta ataatattaa gataattgaa atctgaatat 3358561 gaagttgtac cttatcaaga gaggtggagg gactggccct atgatacccg gcaaccgctg 3358621 tttcaaacag aatggtgcta aatccttaag aacattgcgt tcttgcagat gaggcggaga 3358681 tttgatcgtt caagctcttc cttacacaaa ggaagagctt tttacatgct taatatttca 3358741 gaaaagaggc gaataacatg gctcaacaaa cgaatgttgc aggacaaaaa acagaaaaac 3358801 aacgcaaagc acctttccgc gccgatcatg tcggcagctt gcttcgttcc gttccggtaa 3358861 aggaagcccg gcaaaaaaaa gcggctggtg agatgacagc ggaacagctt cgtgatatcg 3358921 aaaatcaaga gatcacccgc atcgtggaaa aacaaaaaga aatcggtctc gatgtggtaa 3358981 cagacgggga attccggcgt tcctggtggc attatgactt cctggaaggg cttgacggtg 3359041 tggaaccgtt catcccggct gaggggattc agttccataa cacaaaaacg aaagcgcgca 3359101 gcatcaaagt gacgggaaaa ctcgatttta cgagccaccc agcgctcggt gattatcaat 3359161 ttttacatga gattgccggt aacgcgacgc caaaattgac cattcccagt ccaaatatgc 3359221 tgttttttgg cgaaaaggcg gataaaggga tttatgacga tcaagaggaa tactttcatg 3359281 atatggccca agcgtacaaa aaagcaatca aagccttcta tgatgctggc tgccgttatc 3359341 tccagcttga tgatacgtca tggtctctct tctttgagga caaaggcaga gaggttgtcc 3359401 gggcgctcgg cggtgatcca gaaacattgc cagccatatt tgccaaaaca attaacgatg 3359461 ccgtcgcaga ccggcctgac gatttaacga tcacaatgca catttgccgc ggcaacttcc 3359521 gctcaacctg ggcggcatca ggagggtacg acgctgtagc ggaaacgatt ttggacggct 3359581 taaaccttga cggccttttc ttggaatacg atgatgaccg ctccggaaac tttgatccgc 3359641 tccgttttgt gaagcgcaag gatctgcaaa ttgtgctcgg cttgatcaca tcgaaatacg 3359701 gcgagcttga aaatcctgag gatgtgaaac gccgtatcaa tgaagccgcg cgttttgtca 3359761 gcttggacca gctatgcctg agcccgcagt gcggtttcgc ctctacagaa gaaggcaacc 3359821 ttctgacaga ggagcagcaa tgggcaaagc tgcgccatgt catcgacatt gccaacgatg 3359881 tgtggagata atctatcatt gacagaaata gaaaatgtgt gaataataga tactatcaga 3359941 aaatttaata aaaaggtttt ccttatcaag agaggtggag ggactggccc tgcgataccc 3360001 ggcaaccgct gtttaacaga atggtgctaa atcctttaga gcaatgattg ctcttgaaga 3360061 taaggttgag attgtcacgc aagctcttcc ttatccaaag gaagagcttt tttatatttg 3360121 aatggaaaga aggaatggac aacatgtcac aacaaacaac acccgcagaa caaaaatcac 3360181 ttcaaagaaa aaaaccgccg tttcgcgcgg atcaagtcgg aagcctgcta agatctgagc 3360241 ccgtcaaaaa agcgcggctg caaaaagcgg ccggcgaaat gaccgctgag cagcttcgcc 3360301 aaattgaaaa cgacgaaatc atccgcattg tggaaaaaca gaaggaaacc ggcctgaacg 3360361 tcgtgacaga cggtgaattc cgcagagcat ggtggcactt tgatttcctg gaaaacttag 3360421 atggcgttga gccgtttact cctgagcaag gcattcaatt ccataacgta cagacaaaag 3360481 cacgcggcat taaagtcaca ggcgatatcg acttttcaac tcacccaatg cttgaagatt 3360541 actcatttct ccatagcatt gccggtgacg cgacgccaaa gatgacgatt ccaagtccga 3360601 atatgctgtt tttccgcgga aaactggaaa aggatgaata caaaaacgat tatcaacttt 3360661 tccagcacga tgtatccaaa gcatataaaa aagcgattca agcgttttat gacagaggct 3360721 gccgctacct ccagcttgat gatacagcgt gggccgtttt cttatcagaa aaaggcttaa 3360781 aacaaatcga agcgttcgga acaacgcctg acgagcttcg ccagctgttt gcgaaatcca 3360841 ttaacgacgc gattgcagac cgcccggatg acttgacggt aaccatgcat atttgccgcg 3360901 gcaacttcca gtccacttgg acagcggaag gcggctatga cgcagcagcc gaaaccattt 3360961 ttgacggctt gaatcttgac ggacttttct tagagtatga tgattcacgc tcaggcggat 3361021 ttgagccgct ccgttacgta aaacggtctg atcttcagct tgttcttggc ttagtgacat 3361081 ctaaattcgg tgagcttgaa aatccggatg acgtgaaacg ccgtatcgaa gaagcgtccc 3361141 gttatgtaag cttagaccag ctttgcctca gccctcaatg cggattcgct tcaactgagg 3361201 aaggcaacaa gctgactgaa gaacagcaat gggcgaagct ccgccatgtg gttgagatcg 3361261 ctaatgatgt ttggaaataa gcaaagaaaa aaacacactt gattccctag cggagcaagt 3361321 gtgtttttta tgtcattgtg cggtgtagcc cccatcaagg acgacagcct gcccagtgac 3361381 gcccttcgcc ttctcgcttg ccaaaaacac ggcataatcc gcaatttcct tgacggaaag 3361441 cagtcgcttt tgcggcacaa gcggaaaaat gacttgttca agtacagagt cgtaagggac 3361501 atttctagtt ttcgatagat cgctaagctg attgcgtaca agctgggtat cgacataacc 3361561 cggacagagc gcattgactg ttatgccgtg gggcgcgcct tccagcgccc ctacttttgt 3361621 gagtccaatg acgccgtgct tggcgctatt ataagcggat ttccctgcaa agcccactaa 3361681 tccattaaca gacgcaatat taatgattct gccaaactgc tgttttttca tgatcggaaa 3361741 aacatgcttc attgcaataa agggagccgt cagcatgacc ttgatcagct gttcaaaggt 3361801 gtctgtcgga aactcttcaa tcggagcgac gtgctgaata ccggcattgt tcaccagaat 3361861 atccaagcgg ccgtattgtt tttggatgac gttcaccgta tcagcaactt gcgcttcctt 3361921 tgtcacatca tacggaatgg ccgccgcgtc aaagccttct tctgcaagct tggaggctgc 3361981 tttttcacat gcttccggac ggaggtctga aacgatgacg ctggcacctt cccgggcgaa 3362041 ttctcttgcg atttcgaatc cgattccgcc ggcagcccct gtcaccaaag cgacttgttt 3362101 tctcatgtca aacaccttcc cattaagaat tgagtacaga ctggcttaca gcgaaatcag 3362161 cttctgtttt ttcataaacc tcttcaattg tgacaccatc ctgaagctcc gtcagtgtca 3362221 tgcggccgtt cacaaaatca aatacagcca aatccgtaat cagcctgtgt acgactttct 3362281 ggcctgtcag cggaagggag catgtttttt tcacctttga ttcaccatgc ttattgacgt 3362341 gctccatgat gacaacgatt cgtttcgccc cgttgacgag atccatggcg ccgcccatcc 3362401 cttttaccat tttgcccggg atcatccaat tggccaaatc cccctgctcc gaaacctcca 3362461 ttccgccgag aatagctaaa tcgatatgcc cgcctcttat catcgcgaat gactcagcgc 3362521 tgtcaaaata agaggcgcct gtcacttcag tgatcgtttc ctttcccgca ttgatcaaat 3362581 ccgcgtcttc cgttccttcc agaggatagg ggccaattcc gagcaagccg ttttccgact 3362641 gaagcatgac gtgaacgcca tcgggtatct catttgcgac aagcgtcggc attccaatcc 3362701 cgagattcac attcatgccg tccttgattt cttgtacagc ccgtttgacc attcgttttc 3362761 tcgcttcctt cacttggcct caccctttcc cgatgcttgc tgaactgttc gtttttcaat 3362821 ccgtttttct tggctcgcgc caagcacgac atgctgtacg taaattcccg gcgtatggat 3362881 gtgatctgga tcgagctctc ctgcttccac gatttcttcc gcctcggcaa tcgtgatctt 3362941 gcctgccatg gcggcaatgg gattgaaatt tctcgccgtt ttcctaaaaa tcaaattgcc 3363001 catggtgtcc gctttccacg ctttgacgat cgccacatcg ccggtaatgc ctcgctccag 3363061 cacataagtc cggccgccga atgttttatg ttcttttccc tcggctatgg aggtgccgac 3363121 gcctgtcgcc gtataaaatc ccggtatgcc tgcaccgcct gcacgaattc tctcagcgag 3363181 cgttccttgg ggaacaagct ctacctcaag ctctccgctt aaaaactgcc gctcaaaaat 3363241 tttattttca ccgacatagg aagcgatcat tttcttgatt tgcttgttag ccagaagcaa 3363301 accaagcccc cagtcatcga ctccgcagtt attgctgaca acggttaaat cctttactcc 3363361 ctgatctctt atagacaaaa tgagctgttc agggatgccg cacagcccaa accctcccgc 3363421 gatcagcgta tccccatcat gaatcagttt cgcagcttcc ttgcttgatg acagcacttt 3363481 tcccatattg atgccccttt cgttttcttc tacactagac cagtcaggct gtaaatcgcg 3363541 atcacagcaa atacggcagc cgttttaatg agcgtgatcg caaaaatatc gcgataggat 3363601 tgccggtggg tcaaacccgt cacggccaga agcgtgataa cggcgccatt atgcggcagt 3363661 gtatccatcc cgcctgatgc cattgaaatg acccgatgca tcacctctgg cggaatattg 3363721 taagcctgaa tcgcctgtaa gtattgttct gacatcgcgc ttaacgcaat gcccattcct 3363781 cccgaagccg agccggtgat tcccgccagc gcagttgtcg taacggcgcc atttacaagc 3363841 ggatcggtaa aagtatgtga aattccgctg ctcagcttat gaaaccccgg cagcgcggcg 3363901 ataatgccgc cgaacccgta ctcagcaccc gtattcatag atgccagcaa ggcgccgcca 3363961 attccttcat tcagcccttc cttcaattgg gcaaacacac ttctccaatc aaataatatc 3364021 gttgtgatga tgccaatcac taaagcaatc tccaccgacc aaatagcagc cgctgaagaa 3364081 atatcaagcc tgccgaactc ctttaatcct atggaagaaa aatcaaatcc attcggatac 3364141 cactttggca ggtaaatggt gaaatattta ttcactgcac cgacgagaat aagcgggaca 3364201 aaggcaagcg cgtgccgaat cgggcttttg tccggttcag ccgcggactc aatcgattca 3364261 ggagcaggag cattctgcga atcaaaaccg ccatagcctt cgccagatgc ctgcgctttc 3364321 ttccgccttg attccaaata gagcatccca gctgccagca caatcactgc gcccatcaaa 3364381 cccagccaag gggcggcata aatgtctgtt ttgaaaaacg acgtcgggat gacattttgg 3364441 atttgcggcg ttcccggaag tgcgtccatc gtaaacgtaa aagctcctaa agcaatcgta 3364501 cccgggatga ggcgttttgg tatgtttgct tcttggaaca tgtttttcgc aaaaggatat 3364561 acagcaaata cgacaacaaa caggctgaca ccgctgtacg tcaagacagc acccatcagc 3364621 acaatggcaa gtatcgctct ttttgccccg acaagccgga caattgtttt cgcgattgat 3364681 gccgcaagcc cggccatttc aacgaccttt ccaaaaatag caccgagcaa aaacactggg 3364741 aaatacagct taataaaacc cgccatcttc tccataaaaa ttgatgaaaa aaaaggaagc 3364801 acatggcttg gatctgtcag cagcaccgcg aataacgcgc aaatcggcgc aaacaatatg 3364861 acagaaaatc cccgatacgc cgtaaacatc agcaaaccta acgccaatag aatgatgatc 3364921 agttccacac acacatcccc cgtttccgcg aactagaaag cgtttacaaa aacctgtccg 3364981 catcggctgt ttccgtcccc tttccatatg tacgagaagc gtgggccaac tattccgatt 3365041 aaaaaaggaa agctcctttt ttcggagctt tcctctacca ttcatttcat tcctattagg 3365101 atatcaacat caaccgtaat atcggctgat ttcatctctt tcagcaggct gactcgatct 3365161 ttcggcgccg accaggcaag cggcgtcatc ttgagaagcc agtggatcgc ctgctggtca 3365221 agcgttttaa catagcgcag cctgacagga cggctgtgtg ctgcatttgc tgtaaaacgc 3365281 tcaactgctg ccgtattgga atacgtgcgc cttggtgaat cagtatataa aaattgcctt 3365341 aattctatta aatagtcgct tcgcggcact acttttatga gcatgccatc attcttcagc 3365401 agtctatgaa actctgcata attggacggc gaaaaaatag acagaacaac atcaaattgg 3365461 cgatcatgaa aaggagcacg cgccacatcg gcaaccgccc acatcagatc tttgaatgcc 3365521 ttagaagctt ttaagatccc gtccttcgaa agatctatgc cggttcctat cgctgctttc 3365581 cctgcataat caaacccgca aagcgcattc aaatgagaac cctcaccgca accgctgtcc 3365641 aagatggtga atgcctcatg accagatttg ggatgactga tgagctctgc aatcgcatca 3365701 tggagcgggt caaaaaaacc acattctcca atcagcctgc tcctcgcttc aaaaagctcg 3365761 gcaccgtaac tggttttgac cggcttcgtc agaaagttca cgtagccgtg ccgagataga 3365821 tcaaatgtat gtcctcgttc tgtacaaatc aagcttttcc ctgatgccgc atccatagaa 3365881 gaatcgcaga gcgggcatcg aaacatgctg aaatcaactg ttcgcttcat gataaaaaac 3365941 accccattca ttcattttta gataaatgaa aaaggcatag acaaataaac ctaggcctat 3366001 ctcaaaaatt ggccaggtct ggcagtttgt ctacacctgt cattatctat aacgaatgaa 3366061 ttggataatc atgaaaaaaa ctccctttct gctgtatggg tttccccgtt tccatcatac 3366121 aacaaatatc caggagctgg aaccttatag tgaagaaaaa tcagtactga catgctggta 3366181 tcccgccaac atcatatcag catagcaatc cagcatgttt ttcctttatt ttctcatttt 3366241 agaatataaa ttttattatt gtgaaaatag ttaaaaaggt tgattttcaa aaagtgaaag 3366301 gataaaatac tgctatcatc ttagaaaaag acattcttgt atatgatcag taatatggtc 3366361 tgattgtttc tacctagtaa ccgtaaaaaa ctagactaca agaaagtttg aataaatttg 3366421 aacgagttga aaaggacaag ttcttttctg tttgctctta tttttcacac tttctgcact 3366481 tccagaattt gtgaaggata agagcttttt ttgtttccat aataaccctc ataggagttg 3366541 ctatcatgta ctttttacta aaccttgtcg gtctcattgt gattatggca gttgtattcc 3366601 tatgttctcc gcagaaaaag aaaatcaagt ggcgcccgat cattacgtta attgttctgg 3366661 aattgctgat tacttggttt atgctgggaa caaaagtcgg aagctgggcc atcggtaaaa 3366721 tcggtgattt cttcacttgg ctgattgctt gcgccagtga cggtatcgcg tttgcctttc 3366781 cgtcagtgat ggcgaatgaa acagtagact ttttctttag tgcgcttctt ccaattatct 3366841 ttatcgtcac attctttgat attttaacgt atttcggcat tttgccttgg ctgattgata 3366901 aaatcggatg ggtgatttca aaggcttccc gcttgccgaa attagaaagc tttttctcta 3366961 ttcaaatgat gttccttgga aataccgaag cacttgcggt catccgccag cagcttacgg 3367021 ttttaagcaa caaccgcctg ctcacattcg gtttaatgag catgagcagc atcagcggct 3367081 ccattatcgg atcttatctt tcaatggtgc ctgcgacata cgtgtttaca gccattcctt 3367141 tgaactgctt aaacgcgctg attatcgcaa acctgctgaa tcctgttcac gtgccggagg 3367201 atgaagatat catctataca ccgcctaaag aagagaagaa agactttttc tctacgattt 3367261 ctaacagtat gcttgtcggc atgaacatgg ttatcgttat tttggcaatg gtgatcggat 3367321 atgtcgcatt aacgtcagca gttaatggca ttcttggcgt tttcgtacat ggcctgacca 3367381 tccagacaat ttttgcttat ctgttcagtc cgttcgcatt cctgcttgga ctgccagtgc 3367441 acgatgcgat gtatgttgct cagctgatgg gcatgaaatt agcaacgaac gagtttgttg 3367501 cgatgcttga cttgaaaaac aatctcaaat cccttccgcc tcacaccgtt gcggtggcga 3367561 cgacattcct gacgtccttt gcaaacttca gtactgtcgg catgatttac ggcacgtaca 3367621 attcgatcct tgacggagaa aagtcaacgg tcatcgggag aaacgtgtgg aaactgctcg 3367681 tcagcggaat tgcggtatct ttattaagtg ctgcgattgt cggcctgttt gtgtggtaga 3367741 aacattgagc catatccctt ttcggatatg gctcttttca ttattgataa atagaggctg 3367801 gcacctgcac atcccggatt cccgctgcat aaggccccaa gtcatactgg ccgaagacga 3367861 tggcgatccc gtttgccgta aagtaaaaca ttgtgtctct gtttagggtt atatcctctt 3367921 tctttacatc agagaaaaac agcacatcgt gttttttgat atagctatat aggtaatctc 3367981 tcgttttgct gacttttgtt ttggtgttca gaatctgatc cagcgtcacc cgcttttgtg 3368041 ctttcaagtc atagttgaag gactggacag acgttagacc gtgggcgccc cctgaataga 3368101 tataattgag tgtttgaatg ctgagcttgc ctgccgcatt gtatttgacg ctgaaggatg 3368161 tttgatattc ccgttttaaa gccctgctgt tcgcctgctt ttttgttttt caggtattcc 3368221 tgatacgatt gttcatgtag gctttcagct cttgattgat tttcttttca aacgcggcat 3368281 tcccgacgtg atgcacttgt ggatacgtta actccttgat ctttttgtac gtatgggtgc 3368341 tgacagtcgg tgttttcgct tgaactgctt ttaaagatgg ggccgcatat gcaaatacag 3368401 aaaaaagcaa gactgcaatg cccgcggctt tcagcatgtt attccatttc atacaatcta 3368461 ctcctttgat gtcgttgttt atcattccct tatttaagca atacacactt ttatagactg 3368521 attaaatcga aagaagtttc taggtctaac agcatgattt ttccaataaa aaaagagaca 3368581 caggatgtct ctttttttac tgtttgcgcc cagaaatcgc ttcatgaagg gcttgtgcca 3368641 aatctgtatt tccgaacatc tctaataccg caatgacagt ctggtccgga atgtgctctg 3368701 cttcgtgttt tggcacgacc agatcgtcca tggttttttt caagctttca ttcagctttt 3368761 gctgcggata cgctttggcg tacagctcca tcggatcaag atcatggttc acgcaccact 3368821 gggcaaacac caaaatcatc atattttcat cgcgttcgta agcttcagtg agctgttttt 3368881 cgttcatttg tcatgctcct tatgaaaagt atcttcctta aagatacagg agccgatcaa 3368941 attcgtctat cccaatggcg atgagcagca accgcatcga taaatgcctt gctgaaagcg 3369001 gtgtagtcag gttcatcttt agccgttacg atgcctagcc cctctgttgt cccgacagag 3369061 gattgaagaa ggtcaattcc ttcatttgcc gcaccgatcg ccttgtagtg attgtaagct 3369121 tctctgataa acgccatcgc ttgtttgttg tcttttaact ccagtcctcc tgcggcatag 3369181 acggcatcat acagaacaga atcaaccgtc aggaacgtgc cgctggcctc aagctgctgt 3369241 ccgctgccgc ttgtcatata ccccagattt tgactgatga tatccactgt gattccttct 3369301 tgctttaagg cttccagtac tgtttgcagc tctttttcat gaaatccgtt tccggcgagt 3369361 acagcgactt ttcttgttga cgcggttttc actgtacggg cttggcttaa cgcaggcgaa 3369421 gtaagaattt ctttagatgc tttacgcttc gcgggcgccg ccacgcctac tcctttggcg 3369481 atttcttctg ctaaatctgc atcgacattg ctgaagacat caacgacctg ccgctgtacg 3369541 tctttgcttt tgaccttccc gacctcgaag cagaaagcag aaatgatgtg ctgtttctcc 3369601 acaggagaca tgctgttcca gaaaagcttc gcctgtgagt aataatcgtt gaagctgtcg 3369661 cttcgctggc ggattttttt gccctcgact ttttcctgat agtggacgta gccgccttct 3369721 tcagctgtcg caggcgacgg atcattgttt tgcagtgagt ttttatgata agcgacaggt 3369781 cccttattga tcgtcatccg gtgatagccg tcgtattggt tgttatggaa tggacagacc 3369841 ggccggttaa tcggaatctc atggaagttc gggccgccaa gacggatgag ctgtgtatcc 3369901 gtataagaga aaagccgccc ctgcaatagc gggtcattgg taaaatcgat gcccggcacg 3369961 acatttcccg ggtggaatgc gacttgttct gtttccgcaa acacattatc ctgattgcgg 3370021 ttcagcgtca tttttccaat gatcttcacc ggcacaagct cttccggcca cagcttagtt 3370081 gggtcaagaa tatcaaaatc aaacttgaat tcatcttcct catcaatcat ctgcacgccg 3370141 agctcgtatt caaccttgcc gccgttttca attgtttccc acaggtcacg gcggtggaaa 3370201 tctggatctt tcccggcaat tttttgcgct tcatcccata cgagagaatg cacgccgagc 3370261 accggcttcc agtgaaattt cacgaaacgt gcctttcctt gttcattgac aaaacggaac 3370321 gtgtgaacgc cgaagccttc catcattctg tagctgcgcg ggatgcctct gtcagacatc 3370381 gtccacatca ccatgtgggc agactcaggg ttattggcga caaaatccca aaatgtatcg 3370441 tgagcagtcg cagcctgagg catttcattg tgtggctcag gcttaaacgc gtgaaccaaa 3370501 tccggaaatt tgattgcgtc ctgaatgaaa aacaccggaa tgttatttcc cacaaggtca 3370561 tagtttcctt cttcagtata aaattttgtc gcaaagcctc tggcatcccg caccgtgtct 3370621 gcggagcctt tagaacccgc aaccgtagaa aaacggacaa ataccggtgt cttcaccgaa 3370681 gggtcctgaa gaaatttggc ccgtgtgtat tccgtcattg gttcgtaaac ctgaaaaaag 3370741 ccatgcacgc caaatccgcg cgcatgcaca acgcgctccg gaatcctctc atggtcaaag 3370801 tgcgtcattt tctcccggaa atgaaaatcc tccatcagcg tcgggccgcg aaccccggct 3370861 tttaacgagt gctcatcctc tgacactcgc aagccttggt ttgtcgtcat tttcttcccg 3370921 ctgttatcgg tcctgtactg ctcaagctgc tcgtcctttg agtgttcatt tacacgtttg 3370981 ttttggtcat cactcatgtc tgctccccct ttttaaaacg aaacattcta cagcacattt 3371041 acccgtggcg ttcttcatat aaactgctaa tccgctcatt aggatttttg gtctacatat 3371101 aaatatgcgg tcatacacat ttgaaataag ccttcttcac agaaagaaag gatggaagcg 3371161 cttaccaaaa aagctgttga ataggggagg tcatatcatg cttgccatac tcggttttgt 3371221 gatgatgatt gtctttatgt accttattat gtctaaccgg ctttccgctc ttattgcttt 3371281 gattgtcgtt cctattgtgt ttgccctgat cagcggattt ggcaaagatc tcggcgagat 3371341 gatgattcag ggcgttacag acctcgcccc taccggtatc atgctgttat tcgccatcct 3371401 gtatttcggc attatgattg actcaggcct gtttgatcct ctcattgcca aaatcttatc 3371461 gtttgtcaaa ggagatccgt taaaaatcgc cgtaggcaca gcggttctga ccatgaccat 3371521 ttcgctggac ggagatggga caacaaccta tatgattacc attgcagcga tgctgcctct 3371581 ctacaaacgg ctcggcatga accgtttggt gttagcggga atagcgatgc ttggttcggg 3371641 ggttatgaat attatcccgt ggggcgggcc gactgcgagg gttttggctt ccttaaaatt 3371701 ggacacgtca gaggtcttta caccgctgat tcccgctatg atcgccggca ttctctgggt 3371761 gatcgccgtt gcttatatcc tcggaaagaa agagcggaag cggctcggcg tcatttcgat 3371821 tgatcacgca ccgtcttccg acccggaggc cgcaccgctc aagcgtcccg ctcttcaatg 3371881 gtttaacctg ctgctgactg tcgctctgat ggccgcactg atcaccagcc tgctgccgct 3371941 ccctgttctt tttatgactg cgttcgccgt tgccttgatg gttaactatc caaatgtcaa 3372001 agagcagcag aaacgaatct cggcgcatgc gggtaatgcg ttaaacgttg tctcaatggt 3372061 gtttgctgcg ggcatattca caggcattct ctccggcaca aaaatggtgg atgccatggc 3372121 gcattctctc gtttcactca tccctgatgc catgggcccg cacctgccgt tgatcactgc 3372181 gatcgtcagc atgcccttca cctttttcat gtcgaatgac gccttttact tcggtgtcct 3372241 tcccatcatc gccgaagccg cttccgctta cggaatagac gccgctgaaa tcgggagggc 3372301 ctccttgctg gggcagcctg tgcatctgct cagcccgctt gtgccttcca cctatctatt 3372361 ggtaggaatg gcaggcgtca gctttggcga ccatcaaaaa ttcactatta aatgggccgt 3372421 gggaacaacg attgtgatga ccattgcggc gcttttgatt gggattattt ctttctaaat 3372481 gtatgagctt gatcgtagca ttgagtgagt acgtgattta cagaggggag aagatcaaat 3372541 aggatattat gagtgaatag aagattcatg ccaacaactt ctcattacaa tcataagagc 3372601 ctgctatatt gcagcaggct ctttcacatt tggcattatt tttttgtata gcgcacccag 3372661 tcataatgag cgtatagcgg atttacacca ttgtaggagc caagccattc atcgacaccc 3372721 gtgccattcc acaagttcat catgatcttt ccaggtgttg tcggaatttg gtttgttgca 3372781 gtatgtttta attgcccgtc gacataccat ttaatagagt ttggctgcca atcgaatgca 3372841 tacgtatgat aggcattggc tgcatcaaac ccgagatcaa caatcttctc atggtttcct 3372901 gcaccatttg tataatagtt aaattgaacc ttcgttgtgt cttttcctaa aaattcgata 3372961 tcaatctcat cccaaggagt tccatctgtt ggacctgtgt aagtgaagaa cgatgaaacg 3373021 atccctgtgt ttttagctgg tttcattctg acttcataaa gtccatagcc atatgtttga 3373081 acagaacggt tttccccgca gtcaaacttg ttataagctg ggcttgttag cgctaaacgc 3373141 atttcaccca atgacgtcat tgatacgtta ttagcccgcc acgtgcagtt gaacatattt 3373201 ccattcgaat aaccatctgc tttttgccaa aaaccggagt tatagccgtt aaaagggtca 3373261 aaaaacgatc cacctgtttg agctgaggca gtagcagtga ctgcaaacaa actcataaac 3373321 aatccagtga caagaagcag caacactcgt ttcagataag gcatattggc attccccttt 3373381 cattgaaagc gttttctatg ttgatcttac atgattcttt taaaagggaa catcggtcaa 3373441 aataatgata atatcgaatc ttactaactt gaatcctgta actatcatca tcttccctct 3373501 gaaaaaaata aaaacctaaa ttaccatcag cacagacaga gatgatccgc actcattgca 3373561 atttaggttt tgcctgcttt atcagtaaca atcctaccat tttcatatgt gaatgtaaga 3373621 aaaagtgaac acaaggaaac acaaatgtca gcgctctcat tatgcttgtt taactaccct 3373681 ttctatgtga atggttaaat acagcagctc gtcacttgtg agcttgtgct catactcccg 3373741 ctcaatgtag gtttggattt tcttcgtgca ttcatacgcg cgatgatact tttctttcac 3373801 tgtatccagc aaaaaatcgt cctggctttc catgtgagtg ccgttaaata gacgctgcgc 3373861 gaaaaacttt aagtgggtga cgaaccgata atagtgaagc gattcttcgt tgaattcaat 3373921 cttaaaatgg tattttacaa tactcaaaat ctcttgcatg acttttgtaa tgttgataat 3373981 attgggcatc tcttcattca gctcggcatt tacaatatgc agagcaataa agcctgcttc 3374041 atcctctggc agagacacac cagtcttgtt ttttaccata accaacgctt ctttgccgat 3374101 cgcaaattcg tctttgtaga gccgttttgt ttcccacagc aaggcgtttt tgatatcaag 3374161 ccctttctgg ttgcgctgga tggcaaagtt aatatggtcg gtcagcgaca catagatgct 3374221 gtcgttgagc tttttgccga gctgtaattt tgcgtagctg ataatctctt cggatacttc 3374281 catacactcg atcggtatat catacaaaag ggttttgaac ttttctgata catccttgtt 3374341 atcgagcgtg aacactttct caatgcgggc ttcatcgaca tcatcgccgg actttttctg 3374401 aaacgcgagc cccctgccca tgacgaccaa ttctttcccc tgttcattga ccacgctgat 3374461 cacattattg ttgatcacct tcgcaatttt catggcatgt ccctccaaat ctactaagaa 3374521 cagactatat cttgattgta cattcttttt gtactaggtc aatatcatca gggaaagacg 3374581 gaagctggtc agtacaattc actccgtacc tgctgcccgg gctgtttttg aagcagcgcc 3374641 tccagatggc gttcaaatga tgccttgtca gctttctgct ttttgacaat gctgttcatg 3374701 attttaatgc tttcagcact gtattgtgta tattgttttt tcagctgatc cagctgctgt 3374761 cttgtcttct tcgcgttttt cggtgtgact tggttgatga gtttgatcat actgtctgcg 3374821 gtctcaaaaa aaccggctct attttctgtc agctgctgaa tttcgatgcg gctcatatct 3374881 tgattacgcg ttttttgaag caaggcaacc gcctcgctgt tttgtttttt gagcgatttg 3374941 ttctcaagct taatcgattc gagattctcc ttcgcaatgt ctgcttcttc ttcagtcatg 3375001 ctgattcgca cgaagtattc tggattgccg attccataat caaatgcttc gctcacttgt 3375061 atcatggaac tgaacacaat ggccagctgc ctgtcgcttg cgagggcttg gaaatcctgc 3375121 tttttcttac tgctcatcgg tttggctgcg gtttgtttta ctgtcttttg atcacagtct 3375181 gcgaacatct gagcctcacc ttcactttcg catgcgctca tcacaagaac tgtgaccagc 3375241 aggcttatac acaagcctat tcgcctcatg ctctgtctcc tctctgctga atcccttctg 3375301 gaaaatacca taaaatatag ttaaatggta ccagatgcac ctaaccccag caataaatca 3375361 aaagtatgat ttgaagcgaa aaaacataaa tattttgtaa aaattgacgt gcattccatt 3375421 cttttcaggc ccatttctcg tacaatagaa gtatcgttac cggagagggg ctctgatgat 3375481 gaaacgtttt acgaaacaag aaaacagctg ggtgttatat gactgggcaa attcagctta 3375541 ctcaattgtc gtgaccaccg cggtatttcc gttattttat aaatcagcag ctgcggaaag 3375601 cggtgtcagc gccgctcaat cgactgccta tctgggctat accattgcga tttcaacgtt 3375661 tattcttgcg atgctcggcc ctattttagg cacaatcgcc gactatgaag ggtgcaagaa 3375721 aaagttcttc ggtttctttg tgtcagccgg tgtcgccagc accgcgatgc tcgcctttat 3375781 ccctagtgaa cattggctgc tattgttgct gttttatacg gtatcggcta tcggtttttc 3375841 cggcgccaat gtgttttatg atgcctttct cgtggacgtc acgcctgaga agcggatgaa 3375901 tctcgtctcg gcacggggtt ttggcttagg atacattgga agcacgattc catttatcat 3375961 cagtattgct gtcatcctgc tcgcacaagc agagactatt ccagtgtctg tatcggccgc 3376021 aagccagctg tccttcttca taacggctgc ctggtggggg ctgttcacca tcccaatgat 3376081 taaacatgtc catcaacgct attacatcaa aaaagaacct catattgtca tcaacagctt 3376141 taagcggctc ggccaaacga tgaaacggat caggcaatac cgggcacttt tcctcttctt 3376201 gctcgcttat ttcttttata tcgacggagt cggcacgatt attacgatgt cgacatccta 3376261 tggatcagat ttagggatcg gctcctcaag ccttctgatc atcctatttg tcacccaggt 3376321 agtcgccgcg ccgttttcga ttatatacgg aaaactggca gaacgcttca cggggaagac 3376381 catgctgtac gtcgggatcg tcatttatat gatcgtctgc gtgtatgcct attttatgga 3376441 gacaacgctt gatttctgga tactggctat gcttgtcgcc acctcgcaag gcggtattca 3376501 agccctaagc cgttcctatt tcgccaagct tgtgccaaag cgccacgcca atgaattctt 3376561 tggcttctac aacatttttg gaaaattcgc ctcaattatg gggccgctgc tcattgccgt 3376621 taccgcccag ctgaccggta aatcctcgac tgcggtgttc agcctgatca ttttgtttgt 3376681 gattggtatt gtgattcttg cctttgttcc cgaggaaacc agcacagatg tcagccagca 3376741 gcaaaatgac ctgccccttt aactgggagc aggtcattca tcatttattc gctttattca 3376801 ccttcagctg tttccctttg acggttgtgt tcttcatcac tttgagaaca tgagggcctt 3376861 taccatttaa aatctcaacg tatgaggcgt tatccatgat cgtgatgatg ccgatgtcgt 3376921 cagctgacac accgtcaatt ttggcaatcg ttcctacaaa atcaacggct ctgattttct 3376981 ttttctttcc gccgttaaaa tacagcttca taatgtcttt attcagctct tcgcttttgt 3377041 cctttttgct ttccggacgg tcattcagtt tagctagaaa ttctggtttc ttccttgcca 3377101 cttcctcttg agaaggtgct tctatttttt ggatttcaaa tccgatatat tcttcaatgt 3377161 cggctaaaaa ccgtttttcg aaggccgtga caaacgaaat ggcctttcct ttgttccctg 3377221 cgcgtcccgt tcggcccgtg cggtggacat agctttcttt ttcaagcggc agatcatagt 3377281 tgatgacaag ggagatattt tcaatatcaa tcccgcgcgc ggcgacatcc gtcgccacta 3377341 agtaacggta ctcgccacgt ttaaattcat tcatgacgtc gaatcggtct tcctgaatca 3377401 ttccgccgtg aattttatcg catggatatc ccaagtcatc caattcatcg gtcagctgat 3377461 tgacgtgctc cttcgttcgg cagaaaatga tgcagctgtc gggattctcc gtcatcagca 3377521 catctttcag caatgaaaac ttattctctt ctcttacttg aatcaccgca tgttcaatat 3377581 ttcttgtggt taggccggcc gctttgacct cgatatgctc ggggttttgc atatattgac 3377641 ggctcagctt ctcgatatcc tgcggaagcg tcgctgaaaa cagcatcgtc gtacgctcag 3377701 tcggcagatg cttgataatc gcctccacct gctcaatgaa gcccatattc agcatctcat 3377761 ccgcttcatc aatgaccaaa taagagagac gatccaacgg cagcgtgcct ttttcgatat 3377821 gatccagaac acgtcccggc gtgccgacaa caatgtggct tttttgctta agctcagctt 3377881 tttgtttatc aaaggaggat tttccaaata cggctgtcgc tttgatccgt ttaaatcgtc 3377941 cgatgttcgt gatatcttcc tttacttgca ccgcaagctc acgggtcggt gttaaaataa 3378001 gcgcctgcgg cttgttttca tcccaattcg ccagctcaca gagaggaatc ccgaacgaag 3378061 ccgttttccc gcttcctgtc tgtgatttga cgacaagatc ctttcgttca agggcagcgg 3378121 ggatcacact ctgctgcacc ttggtcggtt ctgtatatcc cagtccttcc aatgctcgta 3378181 aaatgtcatg actgatttga tagtttttaa aatgactcat gtataaactc ctgtctcttg 3378241 cagatgttct cattatactc taattgacca aggcatatgt gttttgtcga aaaatgatgt 3378301 attaaaagcc agcgattccc tggcgtttta gctcctgaac agccaatcgc gccagtgcgt 3378361 cggcccccgc gcgattcggg tgcagcgtat ctccatccat ataaagcccg agtgttcttt 3378421 ccggaccgat cgatgtaaag tatgccgagc tgaggacatt taagtcaatg agatatgttt 3378481 tttcctcttc ggccaaagct aaaatagagg ccctgtacca tctgtttaca gacgaatgga 3378541 tgccttcaga agtaaaatcg gttgcccggc cctgaggcgt tgataggatg acgtccgctc 3378601 ctttcgcttt tacctgacga atcatatcac gcatcacctc tttaaactcc gcttcagatt 3378661 ctttatgctt cggatttgtg tcattaatgc caagctgcaa cataaaataa tctccgggtt 3378721 taatatactt cagaatcgcc tcaagctgtc catcatttct gaaccctctc gcgatctgcc 3378781 cgccagacgc catgtttctc acttgaaagg tgtgtttatc gatatagtga ggcagcatct 3378841 gcccccagcc cgcctgcttg ctgctgttga gcggataata attgcacacc gtcgagtcgc 3378901 cgccgacata aatggttcga ttcgttaccg gctgatcaga caatttcttt attttcaagg 3378961 cgctgagcgt aaaagcggtg cctgcctttc cctctgtcac cagcagattc agctgcccgt 3379021 cggtgacggg aatttggaac gtatcctccg cgccatcccc tgtcatattg atgacctgaa 3379081 acacgccctc cgctgccaca ctggcccttg ccgtattgcc aagcgtcacc ttcacctcat 3379141 aaaggccatt cgggagatca acattaaacg tgttattgct tttcgtccca tacgctaaaa 3379201 actgaaccgc atcactcttc acaccagccc cggatgccgc cacatccctc atattctccg 3379261 gtgtttgaaa accgtagccc tttgaccggt cataccgatc agacgccctg acaccaatat 3379321 aaccaggctc catcgaaccg cttccaaagt caaactgata caccttcggc tccgccgcct 3379381 tcacattctc aatcccgcca aaacacagca tcagcatcat cacaaaaacc gctgccatcc 3379441 attttttcat caagactccc cctctatgaa aacgaataca ttaatgcata ctcggtgatt 3379501 gtttctttat gatgactgaa ttaagaaaaa aattgcgttg aggaataaaa atgaggggag 3379561 agtctcaaga aggggaaaat cagtgtgact tcttgtcaca cttgatcaca tcccaacctc 3379621 cgcaatagaa gcttatttgg ttttcttcgt catacacata ataacggagt ctttcccatt 3379681 gatcgtcagt cggtacaatc tccaatgcaa ccgaatcgat ggattcaagg tcatccagct 3379741 ttgatgcact aatgttttca aaccgcaatt gaatgtcaca ggtttgagca gatcgttttc 3379801 attcaaacac aggaatatga atataacgat catcttcttt catatagaaa gaaaactcgt 3379861 ttaatgtaaa tggacctgta tcctcatcag aaagatgctg tttcaatttc tcgtattgtg 3379921 tgatattcaa atgaattccc tctatttata tgattcaccg ccaatcatat aaatgtccac 3379981 agcatcgtat tcaaaccata tgatccgttc gcctgagtcc gttaggcatt ggagcttccc 3380041 ttctgaaaaa tagcttttat ccggttgagg atcagtgatc agaaaaacat catcattgat 3380101 ggaagctagc agaaagagaa aatctgcaat atcccggtct gcttcctgta atatggattg 3380161 gaaatggaat tcccttttgg ccagcttcgt caccttgtaa gcatgacctt caaaatactc 3380221 ggacaggtct tctataaatg aaccagtcgt tattacctgt atcatgattc gatcgtaggc 3380281 aagccctgcc caaaaacgat aaaacgactc tgcatcttca agttcgcatg ccataacggt 3380341 ttggtcaggc ttaagctcga tcatgtccaa attgccaata ctgcttatag aggttatttc 3380401 cataaaatct tccccttatc agttggatag cgcaacgcaa atctcttgtc tgacttgttc 3380461 atacaagaga atgtgatgat acagatcctt atcgtttttg atcatatccg gaagtatgtc 3380521 aggatacagc tcaaaaaagc ttttctccaa cgaacgccgc tgatgccggg gtatcctttt 3380581 attcgccagc acataatcca aactgccagc aacaagcata aaaaactcat agatttccgc 3380641 ttcaaagccg tacaattcat cagggtactg cttttcttca agctctcgct gtctttttct 3380701 cagtttttga agcacgttga tcctctccct tccgcaataa tctcatttat ttcgaaacag 3380761 aataggcgga tcattatcta tcgcctccaa cagctcttca ccaaacacag tgattgcaca 3380821 tttccacggg tctcccaaaa gtccccagga gaagtcctga tgaaaaaaga aataatagtc 3380881 tccatttgga aatacgggaa caggccattc gccaaattca tccttaggca ttgcctgatg 3380941 aggactaaag gtatatccgt catgctgcca atctagtgcg tacattacat cgttctttcc 3381001 agtacctaat tgaaatgctt ttaaaataga agtctctaaa tcacttagca ctccgctcac 3381061 atcattatga ccagctttac tgctcatcgc gcttgagata tcaaacactc gatatggatc 3381121 aggcgggatg atgtgatgac atctgcttcc gggcttccat tttatgatct tgttcacttc 3381181 tgaccagatg cggtcttgtt ttgtctgact taaagcgcgc caattcatca taatctcatc 3381241 cctacacctt attggatatc ctgcttataa acaccagaag aggccactgc gtaaacagcg 3381301 taacttgtca gtttcagctg ttgaacatct aggccttcac cgttcgaatc acagcatgtt 3381361 atctcttcca tctcttgact cacatcggca gaaatcaaat aaagagacga cttaaggtct 3381421 gcactgtaac aattgaacgt cccaaccaaa aaaccttctt cggatatcgc gagctgatca 3381481 aatgcttctg agtccggctc tttatccgac agaatccaca cccgtctcac gaccgtttca 3381541 tcaaatgcgg caatgactgc atctccgtaa tacagcatat aaatcaagcc gtttttttct 3381601 gcaagtccat aacaatcatc tacagcaggc gcatccattt cttcaagctt tctatcaatg 3381661 tgtatttcct tctgctgacc atctaacgta aaacaccaca cactatggcc gttgggattc 3381721 tcatcatgat aaatcccttc atcacataaa ccgacccaaa gctgttgttt ctaatccaaa 3381781 agacagcagg aaacccctga aggcaagtga aaaacacttt tcacccttcc ctcttctgaa 3381841 aaaaccttta ccttcggctc gtacgattcg taataaacga agacatagcc atctgcacat 3381901 tgttgaaaga gcagaatatc actgtatgaa atctgctctt tcactctaaa atcccgaaca 3381961 tcaccggaag gatcatagat tgtaatggtg ataccacctt tcaacccttt tccaatgtag 3382021 acacgcccct gtggatcagc atggaaaaaa caatcttggg tgttctcgtt gatgatttta 3382081 ttcaatttta attttttcat tggttatgct cctaggttcg aaatgaaatg ataagaataa 3382141 accatttatt agctattagt aacggacaac ctagtttcat taatcgtttt gggataaatc 3382201 tactttccaa ttcagcctta aatcatttag tgtttaattg gtatgcataa aacgattgat 3382261 catcaaagcg aactgtttca gcttctatag caatcagcat tctgttcatg tcaataagaa 3382321 agttagcatt tgattgatac tccggaatta tagaatttga tagattcccg attccttctg 3382381 gatgataact catctcaaat acttgccaat tgtattcttc cggatctatt ttttccaatc 3382441 tcatgtcgcc aacatctgca ctataataag cggatgccac attttgaaat gaaattttat 3382501 gcgtatattc accttcatct tcaaaaacct taatatcaag tgagagttct tttttaaaca 3382561 cattaaaatc taaatgaagg acactgcacc ccttatctat ataatcaacc cattcattaa 3382621 tcgtttgata cattgtcatc ccctgcctct ttttaaacaa taacgccttg ccaccaagca 3382681 gaaaacaaat tactccgtat attgtttgat ccaatcattt aaatcatctg ttgaatgcaa 3382741 ataagtttct gatgaatctt tcaaatcaat cccacttaga aggattaaca tatcccagac 3382801 tctatcgtct tctacttcgg ggtcatccgc ataaacataa gttccagccc aatccgacac 3382861 ttcttctctt gttgtttgtc catttaagac acttttgatt ttatttatgc attctattag 3382921 atttgtctcg ctcaatttga tcaccacgta ttcaagtact aaatgatttt ttattagtat 3382981 gcaaagcacc gtactgatat ttagatattg aagctttttc cgtaaaagat atgttccaaa 3383041 aggtttccaa tctaccaata aacaagctca catccgtatt ccgtgtgcaa tatacataaa 3383101 ccaaactggc acttaggctc aaccaaaata aaactatgat tgagaatccc ttcatcgaac 3383161 tcaatacact ccaataagca gtcaaggtgc tcgagacatt ttccaaaaga acaaactaac 3383221 gcaccaattt cgctgctgta ttgatgaaac agcagaacgt cccggtcatc gtaagcaaca 3383281 tatgactgag atattttcca gatcagctgt ttcgcttccg ttttttcgag ggcatcaacc 3383341 tcacgggtgt tggctggtat tgaatttgat aaaaccagct caagcaattg cctgctttgc 3383401 gccagatcag caaaacgata agtgaagcct ctttctgcac aagggactag tttttctttg 3383461 atttcgctca tcaataaacg tcttttattc tcggcgagtt tttcgatcaa tcttttttgc 3383521 atgagccgca ttccctccgc tgtcaatttc tcaacttctt ttaaattgat tcatcattct 3383581 cttgttttcg ttgtcgttca tgtttagatt tgttctaaaa aagcttgtat cgcttatcga 3383641 tacaagcttt atcttcaact gcttaaaact cacccagtgg gcttttcaca aaacgctggg 3383701 aacctttttg gcaaatcctc ttcatcccaa tcaattctat atttttagat tcttttgtca 3383761 tacaaataag agaggatggt aacatctctt atttaatgtt ccatcaataa atgccccatt 3383821 tttatccaat gcagaaatta tttataatta aggaagttta gaaggatttt ttgtattttc 3383881 aagatttaat tttaaagcgg tcacaaaaga ctctagcttt tcttcattac aattaatttc 3383941 gaacaagttg gagttcgact tactttcttt ataatcatca aatataattt taatcttaat 3384001 tctgtaattt ccgttttctt gatcaatact aagaaataag aatggttcaa tagtctctaa 3384061 actgatactg tcttgatttc cttttatcat agtttcgatc ccagatatca acaccttata 3384121 ttcactttct aataaaacag cagaaaaatc gcgaacgacg gctttcttat tttccaacaa 3384181 ttcaaataca gataaaataa atggatcatc gtccaactct tgataccttc tcggtgttaa 3384241 ttcaagttct atacaatcat cttttatttt ggccatattt cctcctcatt taaagtttaa 3384301 gtgagggtag ttgtcatccc cccctcgctt aaccttatta acgccttctc ttagatttat 3384361 ttccttttcc gtgtgtatgg aatacgtgtt tagaaccctt agctcttgaa cttccataag 3384421 ctgtgattac tttacccctt ttatttaaaa caactgtagc tttttttcca acatatttcg 3384481 ttgccccatt aggttgtttt attacttttt tagggcttcg cacagcattc agtttggccc 3384541 ttaaattgac tccacggcct ccatttcttc ctatagattg attaagtcca tgtcttgtat 3384601 gacctgtgat tttaactgcc ttcttcgtaa acttataggc gcgactagca cccttaaata 3384661 tcttcccagg accaaaatta gaagcagctg cccaagcagc acctttccat cctttacctg 3384721 atttatatgc cttatatcca tcataggctg caaatccggc atttaccaca agccataccc 3384781 aatgcccgtc cggatcaaca ttcatcactg ggttattatt tccataagca tacccattct 3384841 gatccaatga atctccgtcg ctgcccgggt ctgggtcgag cgataggaac acgccgtttc 3384901 ttggctcgta gtagcgggcc atgagatagt acaggccggt ttcttcgtcg tattggtagc 3384961 ctgcgtagcg gtagcgattg tcttttactt cgtcgcttgc ttcggttttt gttggatttc 3385021 cccatgcgtc gtattgatac ttggcaacgg tttttccagt gctgtctgag atcgcgatga 3385081 tgtcgccgtg agcgttgtag tgatagaaat atttcttacc attttctgtg taggataaca 3385141 gctggccgct gtctccgtac gtgtatgatt ttgtgacgtt gttgtccgcg tctgtttcat 3385201 acaagacgtt caagctgtct ccgtcgtaga agtagttcgt gacttttccg ttgacggttt 3385261 tttggattct gtttcctttt tcgtcatact tatatgttgc gaatggcttg tcttcgcctt 3385321 ttttggtaac ggcggtcagg ttatcttctg catcccacgt atatgtgaat ttgccgtcgg 3385381 atgtgcggtt gccgttttta tcgtaagaga tgctttcatc attgactttt gtcagctggt 3385441 tcatgatgtt gaaggaagcg ttcaccgttt tgcttgagcc gtcttttata gttgtaacgg 3385501 ttttccggtt tccgaatcca tcatatgtgt attcaataac agtaccgtct tcatgggttt 3385561 ctttgacaag ctgattcagc ttcccatact catattgcac cttgccgctt gctgagctgt 3385621 ttatcgttgt gcggttgccg ttggcatcat attcatagct ttccgtcaga atgtctccgc 3385681 cgtttttgtc accgatatgc agcgagctta caaggtttct ttcgtcatat gaaaaacttg 3385741 ttccgccgcc gttgcccgta ataaaggttt ggacgtttcc attttcatca taatcaaatg 3385801 aatatgagga tgtactgtct ttcatctcaa tcatttgatc cagcttgtta tacgtaaatt 3385861 gattcgttcc tttttggtcc ccatgaatcc acgagaaggt tttcagctta tcggagtcac 3385921 taggatatgt ccaagtttgg ctgccgccgc ggtctgtcag ttcggttaaa cggtttttgt 3385981 tgtcaaatgt ccgtttcttt gtggtgttct gctctttatt gacgaccgac gtttcatttc 3386041 catttttgtc atacgtgaaa atgtactttt ctgtaccgtt atacgacttt gatttcaccc 3386101 ggtctgttcc atcataagaa agagacactt cgttgccatt tggtgaaatg gttttggtca 3386161 ggttgctgtt ggcatcatat tcgcttgcta acacattgcc gagagggtca gttgttttga 3386221 caagcttgcc catgacatca tattcgaatt tataggtttg atctgctcct gcccggatgg 3386281 ttttgcttac ctcattgcct tccttatcat agctgtgaag gatagacgtg ccgttagaga 3386341 gcgtcatgtt tgtcaattgg tctgcctgat catacgtata ggttgttttt tcaccttttg 3386401 catctgtttc agacgttttc ttaccagttt catcgtaatc agttgaagtg gcgtaaccta 3386461 gttcgtcctc ttccttggtc acatagttgc cattactgtc atacgtgctt ttagtcagaa 3386521 ggcttccttc aatcaaacgg atatcatcaa accagactgt gcctgtcgca ctcttttgga 3386581 acagaatact gatatcgact ttattgatcg gctttgtttt agggatgacg acagctgctc 3386641 ggttccattc ctgtgttcca gaagggaatt tcgcattgta gatgcctgtg ctgccgtcag 3386701 cgtaagtgac attcgcctgc agagaatagt ctttttcatc tgtaaatttg acgctgcttg 3386761 ctttcgacat tcctgtcagt gtgagataaa ccggtttgtc atttgcgctt tgccctaaga 3386821 caacggtttg ttttgttact gatccggctt gggacgcact ggtccgggca gcttttaatg 3386881 atacatcatc attaaagcct tcttcagaat caacggatgc tccgcttaca ttccagtttt 3386941 ccgttgctga tgtgaagctg ctgttttgaa ctgggttata gcttgatgat acttcgcctt 3387001 tttccagctg gacttcatca aaccatgctt ttcctttgcc atctttatct ttatgatcga 3387061 cttccatata cacaacagct ttgcctgcat tcgctggagt cgtaaaagtg atttgccgtt 3387121 ttgtccagtc attttttccg gctaatgcac tgtattcatt gtgaatccat tgaattcgtt 3387181 tttgatcttt gtctcgcaaa tcaatgttaa aataggctct tgatttcgca agatctgttt 3387241 tgattttccc gcttaatgta taggttgtat tcggctccag ctcaactgtt tgtgttgctg 3387301 acgaataccc atgatctgtt ccggcagacg ttgattggct caagacctcc aatgcctttg 3387361 atccggaaag aactccgctt ttatcggcga tgactgaaat tttgccgctg tctttagagg 3387421 cagtcagatt ccagccggat ttttgagctt caaagcttcc atctttcaaa atattagttg 3387481 aagctgataa atctttgctc gattgaatct ggtttccata tttatcataa acagctgctg 3387541 acgatgattt tccgctctga tcggtttcgg atacagcatc cagtccgtca taagcaatat 3387601 ccgtgacatt gccctcggta tccttcatct ttgtgacatc gttgtttttg ttgtattcgt 3387661 atgtctcagt tccatatgca tctttaaccg acgtaacgtt gccatctttg tcatattgat 3387721 agctttccgt tgcttttccg gtgccgacgt catttggatc tacatcttct acaacattgt 3387781 tgccttcata ctttgtattc gttgtaattt ttaacccttc cgcatcatca atgacctgaa 3387841 tcggatttcc cgcttcatta tagccatact gtactttccg gccatttggc tgtgtcatga 3387901 gaagcgtctt tttatcagca tcatagctgt agacatatgt ttctttttta gcgttgatcg 3387961 ctttttcgag acggtgaccg ctatactgat attcggtaaa gacaggcttt gcttcggtac 3388021 tgttagctga atattgtttg acaaggcgcc cttcactatc gtagtcatag cttgtgacag 3388081 tcccgtctgt atctgtaacc ttcttcagca aatcattctc atatgagtag gtgactttct 3388141 tattcttagg tcctgtgatg gacgtcacat ggccgttttc atcataggta aatgtaagct 3388201 tgcggcctga tgcatctgta atggcggtca gttgattttt gtcattgtaa gtatagacag 3388261 ttgcattgtt atggccatcc actacctttt ggagtttgcc gcctttttta ttgaaataag 3388321 cgttggtttg atcctttgtt tttaatatga actgatcagc tgtttctgtt aattcaagat 3388381 atacaccggt cggcggctga tacgtgccat cggctttttt cgtgaatcga tgtgtcgtag 3388441 cgtcttcatc gatatacatt gccccgccat ccgttgagat gacagatgtt tctgcatcag 3388501 cataccagcc ttgtccaaat aagtgatcag agctgtcaag actgttgtag gttctcgata 3388561 agccaagtcc cggaccgcgt ccatcaattg acaaatcttc ttcattcaca atgacattgc 3388621 ctgtcgcacc atttaactgg ccgcttggga tatcaatgat agaccagtac tcttctgtac 3388681 ctaggaattc tgcgccttca tggaacgttg ggttaaaggg cgccgttgga atcgtttcac 3388741 cattcgcatc ataggcgaca agcgtgaaag aataattctt cttccctttg taattcccat 3388801 ttgcattgtt atagacaggt gatggatcga gggctaattc cccgcctttt ccatctgtat 3388861 gaagcttata gcttccggct ttgatttcct cagaagtcgg ccagatgttt ttattttggg 3388921 ttgtccaatg atcagcatca ccaacatcaa aggactgata ttctttaccg ttgtaaatgt 3388981 taactttata gcccttcgca ttttgaacct tttcccatat caaattcaca taacccgttt 3389041 gactcgattt tgtatttgta tacaaatagc cagttacatt ctttggccta gcgatatcag 3389101 gaagtgccgg ggtagcagcc ggggatgcaa tggcttcgcc gtctttgttg tatgcgataa 3389161 ttttaaacga gtaatttctt ttggctccat ctcccccggc gtttttatag gttggtccgg 3389221 gattgatcgg cagctctgct ccgcttccgt cctttaggtg aagagcatat tttcccgcct 3389281 tgatttctgc acttgtcggc cagatctttt tcccttttgt ggtccaagac gtctgatttc 3389341 cgagatcaag tgtctcaaag cctttcccat tgaacacctg aaccttatag ccggttgcac 3389401 cggatacagc tttccaagaa aggtcgaagt atcctgtggc attcccatta ttgtagccct 3389461 ttgctgacgg tgcttgtgct tttcctacat tagggataac gggctttgcc ggtgcggaca 3389521 tcgctccttc accttggtca aatatcgcac tgacgccaat ccaatagttt ttgcttgtag 3389581 catagcttcc gccggaattc ttatagaccg gggatggatc taatgccaat tcagctccat 3389641 ccttgccgtc cagatgcagt ttatatctct tggaggcaat ttctgcgctc gtaggccaga 3389701 tttttttacc ttttgtgctc cacgacgtga cgttgcctgc agaaatcgct tgatattcct 3389761 taccattgta aatccatacc ttatatcctt ttgcgccttc aacctttttc cagctgatat 3389821 cgaaataacc agtggaatcg ccgttgtgat aggctttgat tgtaggtgtg tttccctttg 3389881 gaatggtata cgtcacttca atatatggtt tattggcgga gttcgctgaa gaaattagtt 3389941 ttttccaata ttccttgccg tttccgtttg tatgaagctt aaatccatag ttggccccgc 3390001 cggagttcca tgactttaca gcagcggtca catcataact cgcccactgt cctttatgga 3390061 cgtcggcttt tccgatattt ttagatgccg gtttggtgtt ccatgtcact tttgcattat 3390121 cataattgct gttgaccgta tccagccaaa ggccggttgc ctttgttcca taataggaat 3390181 gggctacgta tgtttttaat gtagctttag tgacagtcat attttgaatt ggctttaggt 3390241 tgttaaattt catgaacgca tagtttgtgc ctgttgtttt gtcataatag cccgttttca 3390301 gtacataggc ctttaaatta gcatcccatt tttgtgagga ggccgaatag ttcgtcgtcg 3390361 ggtaggcact catgacaaac gtatccgatg aaacagataa agaagttgac gggtcgatag 3390421 atactggata tacgcgttct gggtctttca gccagttctc gtctgccgta agatgaagca 3390481 aatacccttc ttcattcttt tccagcttat agctgacttt gtctgaccgt tcaacctcgc 3390541 cggaaagctc atctagtttt gaatccgtca taaaaggctt aggcacagaa aaaacaactt 3390601 ttcctttttc atcagaaaaa tcaatggatc catcctcttg ttctttagcc tgcaaatcgg 3390661 tttttaactg aaatgtaaat gtgttgtatc cattatactg atgaaggact aaatcttctt 3390721 ttatgttttc attgaatgtg aaagtctgaa gatcaatatt cggaaacaca tccggataca 3390781 caatctcatt actgtcagtc ttataatctg ctgaggtatc tttcggagta agtgaagttt 3390841 tattcgggcc tttcgcttct gctagtgaat atgtaacctt atggtcatta tgctcaaaag 3390901 tcgcataaag cccgttcttc atttgctttt gaaaatctga attcaaaata gcgttctctg 3390961 tctcgacttg tttgcttgtc gactctttta actcaggaga aatgtcttcc cagtcggcat 3391021 ccggtgtttc ctttgtatga ataggatcaa ggtatacttc ctgtttatag acaccgtcac 3391081 cttcataata gagttttgta ttttctgttc tttcagaggt gatctcaccc tctttgttta 3391141 tatcttttgg atcaaaaggt acagcttcct cagtttgttc tttctgaaga gtttcttctg 3391201 gatcatcggc agcaatacgg tttccattct cttcttctgt agattttgct agtacatcgg 3391261 ctggcactaa tgaaatcatt aaagccaaca ctaaaaatgc tgcaatgaac cttttaaagt 3391321 ttcgcctctt tctttttttc atttcctctc tccttttgta ataaaagtaa tatttactca 3391381 ataatcttaa ctagactgaa atatcattac aatatttttc tagaaaattt atcttatttt 3391441 aaggattagc gagagtcaat tgacctaaaa caaaaaaagg ccgcataggc ctttttacat 3391501 tttttattgt atttgttcaa tatccgtacc ctcagctgtc acattcgcct tcccctgcct 3391561 cctgacaagc gtcaaggcca tgcccgcaaa gatcattacg atgccaagcg tttgatagag 3391621 gtcagggcgg aagcctgtga agacggtatc gagcacgatc gcgacagcgg ggtcgagaaa 3391681 tacaatgatt gaaataaatt tcgttgataa aaatcgtaaa ctgtcaaaaa acagcaaata 3391741 tacaataccc gtatggatga tgccggtaga taccaccata atccagtttc cctgagatag 3391801 gtccgcaaaa gcgccaaagt gaataaacgg aatcaggatg ataaccccta aacctgtctg 3391861 caagaaggtg gtcgtgtaag gactgagatt gtgaatgcct tttcccaata aagtggtgaa 3391921 cgcataaaac agtgcggcga gaactgccca tatgatccct gatcccatca gctgtgtcaa 3391981 tgatgtgctg ccgttaatcc cggaaatcag cgcagtccca agaaagcaga tgataatgga 3392041 gctgacggag atcacattta atttctctct gtagaagaag ctccccagaa gaagaacaag 3392101 caccggcgct agatgataaa cagagatggc aattgtaacg gacgtttctt caaaagactt 3392161 aaataagaac acccagttga atacaagaaa gaaaccgcac gccaatgttt gcagcacgtc 3392221 tctcttgctc catttttcag ttttatactg gccggacgcc agccagcaaa agcctaaaaa 3392281 cagcgtcgcg caaaggcagc ggacaaagac caattcaaat gacggcagat tggtatgctc 3392341 tgagaaaaag ccgatggagc cgaaaatcac catagagatg accattttga ttacggctgt 3392401 tgatttttgt tttgacgata tggaaggatc ctgttgcatc aaacgtattc tacctccaat 3392461 actgcatagc ataaactgtt ttttgtgaat tcagaaatct acacatagaa ttcctctttt 3392521 ttacatgtag atattataac acttctattc taaataaaaa aaagcgccca agggcgcttt 3392581 ttttacaaat ctatcgaaca atcaaaaccg ggcatgttga taattgagac actttatggc 3392641 tgacgcttcc aagcatcatt tctttcaggc cgctgatccc ccggctgcca actacaatca 3392701 ggctgacgcc tttctctttt gcgtgattta gtatctcatg cgccggctcg ccattcgcgt 3392761 aaatggtttc agcttgaacg cctttttcgg ctgctttttc ttttgcattc tcaaggattt 3392821 tcaggccctc ttttttaacc tcgttcctga tttcatcaat aaagtgttca ggcacataga 3392881 caattcccgt cagagaagaa gtcgtgacga cggcttctct ccccacatga agaatgctta 3392941 gttccgcttg ttgctctttt gccaaatgca ctgcggcatc aagcgctttt gcactcatgt 3393001 ctgatccgtc aatcgctact aacattttgt taaacatgct cttcccgcct ttcggactgt 3393061 gggtggttca tctttctctt ttattgtccg cctgcatttc gttattgtca attgaagcgc 3393121 atgagttttc aaaaaattgt cagagactct ctccgtttgt ggcgataacc tgctgatacc 3393181 agttgaagct ttttttcttg atgcggttaa atgttccatt tccttcattg tcccggtcta 3393241 cataaatgaa gccgtagcgc tttttcattt ccgcagtaga tgcgctgaca aggtcaattg 3393301 gcccccatga tgtgtatccg attaattcaa cgccgtccgc aatggcttcg cgcgcttcaa 3393361 ttaaatgatc acgcagatag ttgattctgt aatcgtcctg aatcgtgccg tcctcttcaa 3393421 ccttgtctac agcgccaagg ccgttttcaa cgatgaacag cggcttctgg taacggtcgt 3393481 ataaggtgtt gagcgtgatg cgcaagcctt tcggatcaat ctgccagccc cattctgatg 3393541 atttgaggta agggtttttg actccgccca gcaggttgcc ccctgatttt gcaagctctt 3393601 ccggatctgt gctcgccgcc atcgacatgt agtagctaaa tccaatataa tccaccgtat 3393661 gttctttcaa gagctcttca tcgccttcag ccatttcaat ttcaatattg ttttctgcca 3393721 gatagcgttt catatatccc gggtatgcgc ctcttgcctg aacatctgag aagaaaagtg 3393781 ttttgcgctc attctccatt gccgcgaaga catcctccgg cttagaagtc atcggatagg 3393841 ttgtcgttgc cgctatcata cagccgattt tcgaatcagg aatgatgtcg tgacccgctt 3393901 tgacagcaag agcactggcc acaaattggt ggtgtgccgc ctggtacatc gcgtttaatt 3393961 tgttttctcc ttcttcaaaa acaagaccgc ctccggtaaa tggcgcatgg agcactacgt 3394021 taatttcatt aaacgtcatc caatacttca ctttgtgttg atagcgtttg aaaaccgttt 3394081 tggcatagcg ttcataaaac tctatgactt tgcgattctt ccagccgcca taatttttca 3394141 ctaaaccgag cggcatctca taatgagaga tggttacgac aggctcaata tgatgcttta 3394201 acagctcatc aaacagatca tcataaaatc tgaggccttc ttcattgggc tcctcttcat 3394261 cgccattcgg aaaaattctc gtccacgcaa tcgatgtgcg gaacgcctta aatcccattt 3394321 ctgcaaataa ggcgatatcc tctttataac gatgataaaa gtcaatcccg ttgtgataca 3394381 gattcaagga agtcattgat tcatcaaatg gagacatgat cccgttcggc gatacgtcag 3394441 ctgtcgaaag ccccttacca ccctcgttat aagcaccctc cacttggttg gcagcaactg 3394501 cgccgcccca taaaaatcct tctggaaatc gtttttcatt tgaactcata ttgatcaccc 3394561 cattagtttt ttcaagataa agcaagcagc gcttcttttg gctgcacttt accgatctct 3394621 ttcaccggcg aaaacgaata ttggtctgtg ttggtcacaa tcaccggggt aatgacgtca 3394681 tatcccgcgg ctttgatttg ctccagatca aaggacacga gcggatctcc cggtgcgacc 3394741 ttgtcgcctt ctttgatgtg agccgtgaac cattgtccct ccagctttac cgtgtccaat 3394801 ccaatgtgta tgagtatttc agctccctga tcactcgtaa tgccaattgc gtgttttgtt 3394861 ttaaaaatgg tggtaacgct tccacgaaca ggcgaaacaa cttctccttc ttcaggctca 3394921 atggcaaatc cttttcccat gaccccagca gaaaacactc cgtctttgac ttcacttaag 3394981 gctttcactt ctcccttaat cgggctgtga atgatctctc tgctgccttc atgcactgcc 3395041 ggctgctggc tgccgtcaga aggcacatcc tcgaatccaa gcaaatacgc agctgctgtt 3395101 cccgccgcaa acgcaatcac aaggccgatc atcgcgtaaa taaacgttgg gccgataaag 3395161 acagggatgc tcggcagacc tgcattcccc ccgacgatat aggaagcaac acccgtcatg 3395221 ccgtaaaacg cgccaccggc tgcaccgcca atcaaagcgg ccgcaaacgg ctttttcaat 3395281 cgcatattca cgccgtacat cgcaggttct gtgatcccca tcagcgccgt gatgcttgtg 3395341 gtaagcgcga gtgatttaaa ttttttgttt ctagagcgaa ggaagacggc aaatgatgct 3395401 cccgcctgcc ccatattcgc caaaaacata gccggcagta aataatcgtg gccgttttga 3395461 gcgatgttgt tgatcatgat cggcacaaag gcatagtgca tgcccgtcat aatgattaaa 3395521 gagaatgtac ccgccagcaa aatcattgcc acaagccctg catgatcaaa caaataattg 3395581 accccagaag acaagtattc tcctaaaata gcgccaagcg gaccgactgt aatcaatgtc 3395641 agcggcacga caatcaatag cgtgaatgtc ggaaccacaa tcaatttgag agatgcgtgt 3395701 gtaaaacggt caatccattt ttccacgtat gaagcaatcc aaatcgacag caaaatcggg 3395761 atgaccgttg acgaataagt ggcagcggtt acaggaagcc cgataaagga aatcggtttc 3395821 cccgcaccga gcagggctgt caaatccgga tgcaggatcg ccgccgcaat ggcagccgct 3395881 acgtacggat tgcttccgaa ttttctcgcc gcactcatcg ctagcaggag cggcaggaag 3395941 tagaacgcac cgtcaccgac agccgtcaaa atgacatgaa cctggctctt ctccgccatc 3396001 cagccaaacg tgactgccag cgccacaagt cctttgatca tccccgctcc cgcaatcgca 3396061 ggcagaatag gggtaaacac cccagaaatc acatcaaaga ccgcactcag cacattcttt 3396121 ttctgagagg atgaaccagc gctcttttca tcactgagat tgctgtgccg cacaatcgcc 3396181 tgatacacct tcggcacatc gtttccgata atgatttgaa actgctcgcc gctgatattg 3396241 gtgcccatca ctccaggcag ctgctccagc tgactgcgat ccgccttcgc gttgtcatga 3396301 agattaaaac gcagcctcgt catgcagtgg atcacgcgct gaacgttttc ttcaccgcct 3396361 acgagttgta atatgtcctt cgataattta tcataatcca tgtgtatacc tcctttttat 3396421 ggggggactg ctggatgaaa ggtggccgcc tttcaccagc tttttttgta tcaaatgctg 3396481 catcacctcc taaaagagaa taaaaaaacc taaatgacac agattgcgag agtctcctcc 3396541 tgcacctgca ccatttaggt tttgcctgct ttcgcagtaa caatcctgac gggtcgtttt 3396601 atttgtttgt aggtatactt tagcactaga ttcgtgagat gtcaacgctt tcatttttgg 3396661 tgttgactat cgtttctaga acaaaagtaa tcataaagat ttgaacttag tattaacttc 3396721 aataaaaaat tattgtaatt aaaaaccttg aaaggcattt tttccaatca aggttatgaa 3396781 tcgttaccgt ttaaattttt ttaaagactt ctttatctgt actattacat tctttagcca 3396841 atctattggt tctaaattaa acgcaggaag atacacgcca tctgcgcaag attgaatgta 3396901 atcgtttttc ttattgtctg aatgctcact ttcaataaaa tccgttaaaa agacaatagc 3396961 atcctccaaa tattccttac tttcctctat taataactct tgtatagcgt catcaggagt 3397021 ttcaatatct tgatggaatg ttccagctaa aaactgaaaa acagggtcct tctgtttatt 3397081 gatcaataac atgtcatctt gctcctttaa gggagaggta acgggataat gttaaaatca 3397141 ttcatcatct aataaatcaa gataatactg atcattctct tctatttttc ttaagaactc 3397201 ggtaagagaa gttgcaattt gaatatcata atagtaaatc ggatttttat tattatcatt 3397261 taattcaatt gacattaatg ccgattcact accttcaaaa aatattaatt tatcattctc 3397321 aaactcatca tatatttcta tgtcaggata aaattcaaag tcatttatcc tcaatcgaaa 3397381 gtctcttaca gaatatggat ccaaaatgcg attagtatta aactctgatc ctttaataaa 3397441 cccatagcca acttctaaat aaaaattcac taattcacta ggtaatttta agtttaaatt 3397501 tttttcaacc tcttcaatct cactttgatt cactggataa aaatcatttt ctttgtttga 3397561 ttttataaaa ttataactca tttttttttg cctcctttaa ataattcatt tgctggtgag 3397621 cctgtaccat gaatcccagc ttgatgctcg ttaggaaatt ttgctggatg catattccac 3397681 cattcatgtt ctccgccaaa agtattttca attatatggt gagcatcata cttatcccct 3397741 ttttttctaa taattttacc tgttttttca gatacaacat tttccttata aacaggccat 3397801 ttttgtccag tgttttcttc ccattctttt ataactttat tttttacttt atcaaattta 3397861 gtcctgtgtt ttgcagtctc tattggtgac atttttttat attctttatt tcttaatgct 3397921 tcctttaatt tatctatttg atttttaggt aattctctac ctgtgcgttg ttctatatct 3397981 ctagcatact tttttattaa atcagaatta attttattag cagatccact tacatcattc 3398041 gcaattttcc ctttatcctt agcaacgttt ttaacttccg aagccttctt agcctttttc 3398101 ccattattaa taagtttatt aatatctatt aacttttcta acttagctat tttggcaaat 3398161 ggtactgagt ttatggaggc aacaacacgg tctttccctg tgactttttc gcctgatacc 3398221 ggatctctgc ccgtggctgc tttaaataga tcatacacgc cggtaagttc tacagccgtc 3398281 tctaaaattt tcacatatcc attctcatcc actttaatgt ccgaaagcga gacgacaggt 3398341 tcaagcttca tgtcattacc agatatgtat acattgtaaa gtgtatcatt ataaacgact 3398401 tgcttaacct ctgcatttga gaaatcagtt tttatatgtt ctctatgttc actcgtatta 3398461 tacactttac cattgataac gatgatattt ttacttacct ttttagaatc acccgttttg 3398521 acaactgaat ccactttaga cttttcattc tcggctaatt tcttcagcat catctccatc 3398581 ggtgaatcat ccgcctgctt catttgcggg ttaatcgcgc cgaagatttg gttgatgttt 3398641 tcttcttcct gtgatttcag gatggagccg cttttgtagc ctgtgatttc aattttcggg 3398701 ccggtgtaca tggtttcgag ctgatcaatg tattttttca tcgtttgaaa atctgatttt 3398761 gcggcttcta gtgcttgggt ttgctggccg tcaaattgaa agagcttatt cagggtgtct 3398821 gaaatcagcc gctcagcctg ttctgtttcc atccgaaaaa aggaatcatt gactgtcggc 3398881 aggctgacga tgtgatctat ggctgatgtc tggcgattga ctgcgtcagt gagctgctct 3398941 gtcacttctc gtgcatgctt gaccccatgt ctcgcatcgt gtgagagaaa agcctctgcg 3399001 atcatgccgt gggagttaga ttctacagag gaaatcgcat gctgtgtttg tttcagcact 3399061 tttttgtatt cgtcgataaa tatgccaaag aaaaggagaa aaggcttgtg gcactcctcg 3399121 taaaaggtcc ggatggcatc tccgcctttt cctttcagcg catccttcat gcctgccaga 3399181 tgctcaacgc ttttttccag cttctccagc tgttgttttt gcttgtccag tttctcaatc 3399241 gtatgctgaa tgccctcgtg aagagcgtgg acatctaatg ttttcaatcc cttgtcctcc 3399301 cgcgctttat ttcatggaag atgatatgtt ttcgtccgtt tccttcatgg cgtttaccgc 3399361 gctttccgtt tgtgcgatat gcttggccag aacagacgca tatgcttcag tgagctcttt 3399421 gatgtcctta tttaattgct cgatggactt cacaacattc aaatggtttc tgcctgagag 3399481 atgaccgggc aatgaggact tgagttcagc tgaattcttg agctgagaaa gcccttgctt 3399541 cactgtgtca tacaccattt taatttcctg tgccatttgt gctcacctca ctttttatgt 3399601 ttttccttct ctatttcatg ctctatcctc gtgatttggc gtcttataga atacacatcg 3399661 ccctctaatg agtggatttt tccttctatg ctttcgatga ttccgctgac ttgatcgctt 3399721 ttgatttgct gatatgcttt gttcattcct tcacgaatat cttcaaaccg ctcagcatgt 3399781 gttcctctcc atgcctcccg gttaagatga ggccggtgaa tgagatgctg ggcctcagag 3399841 aaatcgtgtt tgatttgcct aatttcgtgc agcactcgtt ttaattgatg gatctgttcc 3399901 tgcttttcat gtaagtcggc ttttaccgaa tgtaacaaca tttcactatg catgccgcaa 3399961 cacctcgtgt ttctatcaaa ctgtgtaaat tctttacaat acagactatt ttcatattac 3400021 atgatgggtc atattggata aataggtaaa aaggattgtc ttgagaggta tagaactggt 3400081 tctaaattgc taaaaatacg atctcatcac cctatgaaag gagaaaacaa tcatagtagg 3400141 gactttttat ttaagccttt aatctctcct ccagttctaa tttttcctcc cacttaactg 3400201 tttcttatag tcaataaagc tcataaaaaa acaccttccc tcgaaggcgc ttctccatct 3400261 tatttagatc cccatacagc ctcaccgctg gtattcagca cactaaacgt catgacgttc 3400321 ttctctctca ccgaatccca ctggcgtaaa aataccccgt tatacttctt gcctgctaac 3400381 gtgatgtcgg cggtgttttt tccggttttc ctccatgttc cggtcatttc cccggaaatg 3400441 gtgtggtttt tgttgagctg gatgttgatg gtttgtttga tgtcggctga gatgtctttt 3400501 ccgtgctgga taagtttgta tgttcctgtg atgtcttttt gttttacttc tttcaatgtt 3400561 tcgcccgcat aacgatatgg tgctgctacc ggccagccgt ctttgttcat gaacaattgg 3400621 tggactctga cttcgtgttc ttcacccctg cccgggaagc gggtgtggaa gattaaatag 3400681 gaacgcccgg ttttttcatc atagtatgcg gagttgtggc ctggtgagac gtacccggtg 3400741 cctttttcat tttctgtttc aaaagtgtag ctgcccatga gtttgacgcc gtatggttcg 3400801 atggaacggt cgtcgaagaa tgtgcctccc ttgccgcgga cgtcgagcat tggattgcct 3400861 tctgcatcat agtaagggcc gtccggtttc ttggagcggg ccacacggat gttgtagccg 3400921 cctgttgcat cgagaccgcc atatgatagg tataagtagt agtattgggt gtctggattg 3400981 tagagaacat acgggccttc gattctgctg tggttgccgc cgagcagttt tttcccatat 3401041 ccctgtccag gaagcgggaa gcccgttttc ggattcattt caagtatgaa aatgccgcct 3401101 gagtatgatc cgtacaccat ccacagcttg ccgtctttat caaagaaggt atgcgggtcg 3401161 acgacattcg gatgtttggt tgcatcatac ggtgttccat cgctgcttgt gccttccatt 3401221 cctgatttca aaaagatgcc tttgtttttg tatgggcctt cgatgttgtc agcaacggca 3401281 acacccatgg cggatcttgg cgaatcgccg cggcaggcgt tgtagtacat gtagtatttg 3401341 ccgtccgcca gctgcgtgac gtcagccgcc caaagagtat cggattgcgc ccattcgaag 3401401 gtttctttta attcttcata gacattcggg ataagtgggt tgtcattgct tacgctggtg 3401461 gtcagctgct gccattgcat gaggtcattc gatttagctg aagcgagatg agatccaaaa 3401521 acataaaaag tgccgtttgt ttcaatgatg gaagggtcat ggacgctgac ttctttaaat 3401581 ataggttttt gtgcatagac ggagtttggg agggtgaagg ccatgataag agctgcaaga 3401641 aaacatacac ggaacaatcg gttgaacatc taaacaattc gcctctcttt tttattaaat 3401701 tttaaacgct tacatttctc tatgaagata ccccggccta ttaaaacagc cgaatgtttt 3401761 catattcatc cagataggtg atttctcact tcacttacat agtcagactg atgtctgtct 3401821 gttttgcgca gaacttgttg cttgcatatc ctctccttca tagttcaact cttttgctgt 3401881 ttctccttct tgcatcacgt ctgtttttct ttcgcgtaca tgtaataact gctttgtcag 3401941 gttttgcatc aactgtgata cagccatttc gttgtcggcg ttttttaaga tgatgcctga 3402001 ttgcccgtca acaccagagt cattcggctg gctctttata aaacgccttg cgaaaaatac 3402061 gacttagtaa acgcatattg agagttagac agcggcgctt gcctccttgt ctggatatcg 3402121 tgtgcaatcg ctgaaaaaac ctgttctgct ttctgcgtca cgctattaca atagcaatct 3402181 aacttgttaa agactataaa aaaacctttt gacttctgct gctgaaccaa ttaatataat 3402241 actcagttaa tagttatcag aatttttagg aattgagtga ttcatatgac actgcataaa 3402301 gagcgtcgga tcggccggct gtctgttctc ctgctgctga atgaggcgga agaaagtacg 3402361 caggttgagg agctggagcg agacggatgg aaggtctgtc ttggcaaggt aggatcaatg 3402421 gacgcacata aagtagtagc cgcaattgaa accgcttcca aaaagagcgg tgtcattcaa 3402481 tctgagggtt atcgggagtc acatgcgctt tatcatgcga cgatggaggc tttgcatggc 3402541 gtgaccagag gtgaaatgct gctgggatcg ctgcttcgga cggtgggatt gaggtttgcc 3402601 gttttgaggg gaaatcctta tgaaagtgaa gcggaaggcg attggatcgc tgtctcgctt 3402661 tacggaacaa tcggggcgcc gattaaaggt cttgagcatg aaacattcgg cgttggaatt 3402721 aatcacatat gaaacagccc atagatctta gacgataggg ggctatgcgt gaaaacagaa 3402781 gttcacagca tagctccttt ttgtatgggc gctttaccaa agtaaagaaa aaggagttgg 3402841 gcttatggtg actttagacg gttcttcatt gacaacagcc gacgtcgctc gtgtgctgtt 3402901 tgattttgag gaggcagcgg cttctgagga aagtatggag cgcgtgaaaa aaagcagagc 3402961 agcagtggaa cggattgtac gcgacgaaaa gacaatctac ggcatcaaca ccggatttgg 3403021 caaattcagc gatgtcctga ttcagaaaga agactcggcg gcgctgcagc tgaatttaat 3403081 cctttctcat gcctgcggag tcggcgaccc ttttcctgag tgtgtttcca gggcaatgct 3403141 gcttttgcgc gccaatgcgc tgttaaaagg cttttccggt gtacgcgctg agctgatcga 3403201 gcagttgctt gcttttttaa ataaacgcgt ccatcctgtc atccctcagc aaggatcact 3403261 tggcgcaagc ggagatctgg cgccgctttc ccacttggcg cttgcgctga tcggacaagg 3403321 agaagtcttt tttgaggggg aaagaatgcc ggcaatgaca ggcttgaaaa aagcaggtat 3403381 tcaaccggta acgctgacat ccaaggaagg gcttgccttg attaacggga ctcaggccat 3403441 gactgcaatg ggggtggtcg cctacatcga agctgagaaa ctagcctatc aaacagaacg 3403501 aattgccagc ttaacgattg aggggttgca gggaattatc gatgcatttg acgaggatat 3403561 tcacttagcc cgcggctatc aggagcagat cgatgtcgca gaacgaattc gcttttatct 3403621 atctgacagc ggcctgacaa cctcccaggg agaactgcgg gtacaggatg cctattcatt 3403681 gcgctgtatt ccgcaagtac acggtgcgac ttggcagaca ctaggatatg tcaaagaaaa 3403741 attagagatt gaaatgaacg cagctacaga caatccactc attttcaatg acggtgacaa 3403801 agtgatttcc ggcggaaact ttcacggaca gccaatcgcc tttgccatgg attttctgaa 3403861 aatcgcaata tcagagcttg cgaatatcgc agagcgtagg atcgaacgac ttgtgaatcc 3403921 gcagctgaat gacctgccgc cgttcctgag ccctcatccc ggtctgcaat ccggtgcaat 3403981 gatcatgcag tacgccgcgg cctcactcgt ttctgaaaat aaaacactgg cccatcctgc 3404041 aagtgtggat tccattccgt catccgccaa ccaagaggac catgtcagca tgggaaccat 3404101 cgccgctcgg catgcttatc aggtgatcgc aaatacaagg agagtcattg cgatcgaagc 3404161 catttgcgca ttgcaggctg ttgaatacag aggcatagaa catgcagcgt cctatacgaa 3404221 acagcttttt caagaaatga gaaaagtcgt gccgtccatt cagcaggacc gtgttttttc 3404281 ctatgacatt gaacgcttga ctgactggct gaagaaagaa tctttaatac ctgatcatca 3404341 gaataaagaa ctaaggggga tgaacatatg actgatgtaa aaaaatcaat ccgtgccaac 3404401 agaggaacag agcttgaatg cttaggatgg gagcaagagg cagtgcttcg gatgcttcga 3404461 aacaaccttg atccagaagt cgccgagaag ccggaggacc tcatcgtata tggcgggatt 3404521 ggcaaagccg cacgggattg ggacgctttt cacgccattg agcattcctt gaaaacatta 3404581 aaaaatgatg aaacattgct cgtgcaatcc ggaaagcccg ttggcatgtt ccgtacacac 3404641 ccgcaggccc ctcgcgtgct cctagcaaat tctgttcttg ttccgaagtg ggcagactgg 3404701 gagcatttcc acgaacttga gaaaaaaggg ttaatgatgt acggacagat gacggctggc 3404761 agctggattt acattggctc acaaggcata ttgcaaggaa cctatgaaac cttcgctgag 3404821 ctggcgcgac agcacttcgg gggcagctta aaaggaacgt tgacgctgac agcgggtctc 3404881 ggcggaatgg gaggcgccca gccgctgtca gtcacgatga atgaaggcgt cgtgattgcc 3404941 gtcgaggttg acgagaaacg catcgacaag cggatcgaaa caaaatactg cgatcgaaaa 3405001 acagcatcga ttgaggaagc cttagcttgg gctgaagagg caaagctggc aggaaaacct 3405061 ttgtccattg cacttctcgg aaacgcagct gaggtgcatc acacactttt gaaccgaggc 3405121 gtcaaaattg atattgtgac agatcagaca tctgcccatg accctttaat cggttatgtt 3405181 cccgagggct attcccttga tgaagctgac cgtttgcgtc aagacactcc agagctttac 3405241 gtgcgccttg cgaagcaaag catgaaaaaa catgtcgaag ccatgctggc ctttcagcaa 3405301 aagggctcta ttgtatttga ctacggcaac aatatccggc aagtcgcaaa ggatgaaggg 3405361 ctggagaatg ccttcgattt tccggggttt gtccctgcct acatccgccc cttattctgt 3405421 gaaggaaaag ggccgttccg ctgggcggcg ctttccggag atccggcaga tatttaccgt 3405481 acggatgcgt tattaaaaga gctgttcccg acaaataaag cccttcaccg ctggattgat 3405541 atggcacagg aaaaagtcac cttccaaggc ttgccgtccc gtatctgctg gcttggatat 3405601 ggagaacgaa aaaagatggg cctcgccatt aacgagctgg ttagaaccgg ggagctaaaa 3405661 gcgcctgtcg ttattgggag agatcatttg gactgcgggt ctgtcgcctc tccaaaccgg 3405721 gaaacagaag cgatgaagga tggaagtgac gctgtcggtg attgggctgt gctaaatgcg 3405781 cttgtcaaca cggcggcggg tgcaagctgg gtttccttcc accatggcgg cggcgtcgga 3405841 atgggctatt cccttcatgc cggcatggtt gcagtggccg atggaagtga gctggctgac 3405901 gagcggctcg cgcgggtctt aacgagcgac ccaggaatgg gcattatccg tcatgcggat 3405961 gcgggttatg aacgtgccgt tgaagtagcg aaggaacagg acattatcgt gccgatgcaa 3406021 aaataaagga gtgatgacat gccaaagcaa attgatacga ttctcatcaa catcggtcag 3406081 cttttgacga tggaaagcag cggtccgcgg gcaggcaaaa gcatgcagga tcttcatgtg 3406141 atcgaagacg ctgttgtcgg catccatgaa cagaaaattg tgttcgccgg acaaaaaggg 3406201 gctgaagccg gttacgaggc agacgaaatc attgactgtt cgggacgcct tgtaacgcct 3406261 ggcctcgttg atccgcacac ccatcttgta tttggcggat ctcgtgaaaa ggagatgaac 3406321 cttaagcttc agggcatttc atatttggat attctggcgc agggcggcgg gattctgtct 3406381 acagtcaagg ataccagggc ggcttcagaa gaagagctgc tgcaaaaagc ccattttcat 3406441 ctgcaaagaa tgctgtccta cggcacaacc acagcagaag tgaaaagcgg ctacggcttg 3406501 gaaaaagaga cagagctcaa acagttgcgt gtcgcaaaga aactgcatga aagccagcct 3406561 gttgaccttg tttccacatt tatgggagcc catgcgattc ctcccgaata tcaaaacgat 3406621 ccagatgatt ttctggatca aatgctttcc cttttgccgg aaatcaaaga gcaggagctc 3406681 gccagctttg ctgatatttt tacagaaaca ggcgttttta cagtcagcca atcccgccgt 3406741 tatttacaaa aagcagctga ggcaggcttc ggattaaaaa tacacgcaga tgaaatcgat 3406801 ccgcttggag gtgctgaatt agcaggtaag ctaaaggccg tctcagccga ccatttggta 3406861 ggtacatcgg acgaaggcat aaagaaattg gctgaggcag gaacgatcgc cgtcctcttg 3406921 ccgggcacga cattttatct tggcaaaagc acatacgcca gggcaagagc tatgattgat 3406981 gaaggtgtat gtgtcagctt ggcaacggat tttaatcctg gcagctcgcc gactgaaaat 3407041 atccagctga ttatgtccat tgccgcgctt catctgaaaa tgactgcaga agaaatatgg 3407101 cacgcggtca cagtcaatgc cgcatatgcc ataggaaaag gagaagaagc cggtcagctc 3407161 aaagctggcc gctcagctga tcttgtcatt tggcaagccc cgaactatat gtatattccg 3407221 tatcactacg gggtcaatca tgtacatcaa gtcatgaaaa atggaacaat tgttgtcaac 3407281 agggagggag ccattcttgg ataagtaccc ttttctcaga gaggccggat cttcgtttaa 3407341 agaccgggat gtcacaaaaa tgagcgacct gatcgcaaca tgggacggcc aggacattaa 3407401 gggaccggcg ttgataggtg tccccctatc aaaatcctcc atcagtcatt caggcgcttc 3407461 ctttgcaccc ggaacaatac gccaggctct gaaacattca tcagcctatt ctgctgagct 3407521 tggagagcac gtcgtatcag agcttctata tgacctgggg gatatcgata ttcatgtcac 3407581 tgatatcgta aagtcacatc atcacatttt ccaaaccatg cacgctctgc tttcggatca 3407641 tccggattgg gtgccgctca tacttggggg agataactct atcagctact ccacaataaa 3407701 agcgatagca caaacaaaag gaacgacagc ggtgattcaa tttgatgccc atcacgatgt 3407761 tcgcaatacg gaggacgggg ggccgacaaa cggcaccccc ttccgccgcc ttttggatga 3407821 agagatcatt gaaggtcaac atttgatcca gctgggtatc agagaattca gcaacagcca 3407881 ggcctatgaa gcatatgcaa aaaaacataa cgtgaacatt cacacgatgg acatgatccg 3407941 ggaaaaagga ctaatcccaa cgataaaaga gattttgcct gttgttcaag ataaaacaga 3408001 tttcattttt atatctgttg acatggatgt cttagaccag tcccatgcac ccggctgtcc 3408061 agcgattggc ccgggcggcc tctatacaga cgaattgctt gaagcagtca agtacatcgc 3408121 acaacagccc aatgttgccg ggattgaaat tgttgaagtc gaccctaccc tcgattttcg 3408181 agatatgaca agcagagctg cagctcatgt tctgttacac gcattaaaag gaatgaaact 3408241 ctccccattc aagtgatctt ctggcaggtt gtattttggg tataagaaac tcatctgcct 3408301 aaggaatggc agctaaaagg agggcgagac agtgaatctt caggagaaca gcagccaaca 3408361 gctaaaacgc acaatgaaaa gcaggcacct atttatgatc tcattgggag gcgtcatagg 3408421 cacaggactt ttcctcagta cgggctatac gctacatcaa gccggacccg gcggtacgat 3408481 actcgcttat gtaatcggcg ggttgatgat gtacctcgtc atgcaatgtc tcggcgaatt 3408541 gtcggttgcc atgccggtga ccggctcttt tcaaaaatat gctacaacat ttatcggtcc 3408601 atctaccggt tttatggtcg gcatcatgta ctggatcaat tgggtggtga cggtaggctc 3408661 tgagtttacc gcatccggta ttctcatgca gcgctggttc cctgacagca gtgtatggat 3408721 gtggagtgcg atttttgcag cccttctttt tatatgcaac gcattttcag ttaagttatt 3408781 tgcggaaact gaattttggt tttccagcgt aaagattgtc accattattt tatttatcat 3408841 tttaggagga gccgccatgt ttggcctgat ctctttaaac ggaacggcgg atgctcctat 3408901 gttgtcaaac ttcacagatc atggcgggtt gtttccaaat ggctttctcg ccgtttttat 3408961 cgcgatgata tctgtgagct tcgccttttc cggtacagag ttaatcggcg ttacagcagg 3409021 agaatcagca aatcctcaaa aggatatacc gcgatccatc cgtaatgtcg catggagaac 3409081 cgtgattttt ttcattggcg ctgtcttcat attatccggg ttgatttcat ggaaggacgc 3409141 aggcgtgatt gaaagcccgt ttgtcgccgt atttgcggag atcggaattc cttacgctgc 3409201 tgatattatg aatttcgtaa tattaacagc cttgctgtct gtcgccaact caggcttata 3409261 tgcttcgacc cgtatgatgt ggtctttagc aaatgaaaac atgatcagct cccgttttaa 3409321 gaaagtgaca tctaaaggca ttcctttaaa tgccttaatg atcagtatgg ctgtatcttg 3409381 tttatctctc gtttccagta tcgtggcccc tggaactgtc tatgtggtga tggtcgcaat 3409441 tgctggattt gcaggagtcg tggtctggat gagcattgcc ttgtcccaac tcttgtttcg 3409501 aaagagattt ttgaaaaaag ggggggatgt aaaagatctg acatttcgca cgccgcttta 3409561 tcctcttatg cctatagccg ctctcttatt atgttctgct tcttgtatcg gtcttgcttt 3409621 tgatcccaat caaagaatcg cacttttctg cggagttcct tgtatcatcc tttgctatct 3409681 catctaccat ttcaaaagaa atgttacaaa agcgaaaaaa atcagccaag aggaatatcc 3409741 agccgatcac atcctataat taaaaaagca caccccgctc agcatgggat gtgctttatt 3409801 ttttattctg taattaacgt atgaatcagc ttcggcgcct tcgcttccgc ggcgatgcgg 3409861 atgttgtcat agacttttgc gatgacttca tcgacgtttt ctcggttagc gtaaagcgtt 3409921 acgagcggtt cccctttttc tactttgtcg ccgacctttt tgcggagcat gatgccgacg 3409981 gctaaatcga tttcgtcttc ttttgtggcg cggccggcac ctaacagcat cgccgcgacg 3410041 ccgatttcgt ccgcgacgat ttcagagacg acacccgctt ctttggcagg cacatcaatt 3410101 tgatatgcgg cttgcggaag cttagacgga tcgtcaacaa ttgagctgtc gccgccttgg 3410161 tttttcagga aatccttgaa tttctcaagt gctttgccgt ttttcatgac ttcttccagc 3410221 ttcgctctcg cttcgtccaa tgtatcggct tttttcgcaa gcacaaccat ctggctgccg 3410281 agcgttaaga caagctcatg aagatcctca ggcccctcgc ctttgagcgt gtcgatcgct 3410341 tctttgactt caagcgcatt tccgatcgca aagccgagtg gctgggacat gtctgaaatg 3410401 acagccattg tttgacggcc gacgttattt ccgatgcgta ccatcgcttt ggcaagttca 3410461 gctgcgtctt cttctgtttt catgaaggcg cccgctcccg tttttacgtc aagcacgatg 3410521 gcgtccgccc cggcagcgat ttttttgctc ataatcgagc ttgcaatgag cggaatggaa 3410581 ttgaccgttc ccgttacatc acgaagcgcg tacagttttt tatcagccgg cgttaaattg 3410641 ccgctttggc cgatgaccgc aaccttgtcg cggttcacaa gtttaataaa ttcatccttc 3410701 gtcagttcca cgtggaagcc catgattgcc tctaacttat caatcgtgcc gcccgtatgg 3410761 ccgaggccgc ggccggacat cttagcaacc ggcacatcaa gagccgcaac aagcggagcg 3410821 agaacgagcg ttgtcgtgtc gccgacgccg ccggtagagt gtttatccac tttaattcct 3410881 tcaatggcag aaagatcaat cgtttcaccg gagttcacca tagccatcgt caagtccgcg 3410941 cgttcacggt cactcatatc ctggaagaaa atcgccatag caagcgcgct tgcctgataa 3411001 tcaggaatgc ttccatctgt atagccgttc acaaaaaatt gaatttcttc agtggtgagt 3411061 tcttttccgt tttgtttttt gatgatgata tctaccattc tcatgtttgg tcaccgatcc 3411121 ttttcgatta agttcagtaa atcaagccca caattgctgc tgataaaaag ctgacaagcg 3411181 tagcaccgta taataatttc aagccgaaac gagcgacgac atttccttgc ttttcattca 3411241 gtccttttac ggcaccggca atgattccga ttgaggagaa gttcgcaaat gacacaagga 3411301 ataccgatac gatcgctgtt gtacggccgc tgaaatggaa accgttttgc gtaagcgacg 3411361 tcatggcgac aaattcattc gataccattt ttgttgccat aatgcttccc gcattaacag 3411421 cttcattcca tgggataccg acaagaaaag cgaatggagc aaacacatat ccaagaatgc 3411481 cttggaacga aataccgaat actgcattaa aaatgccatt gatcaatgca ataatcgcga 3411541 caaatccaat cagcatcgca gcgacgacaa ccgctacttt gaaaccgtca agaatgtatt 3411601 ctccgagcac ttcgaagaag gattgttttt cttcttcctc aacacgaagc atatcctctt 3411661 cttttgcaac ctcgtacgga ttgataatag aagcgataat gaaaccgcca aataagttca 3411721 aaacaagcgc tgttacaaca tattccggtt tcagcattgt catatacgca ccgacaatcg 3411781 acattgatac agttgacatc gcagatgcgc aaagcgtgta caagcgctgc tgatttaaaa 3411841 gaccgagttc tttcttcaag gagataaata cttctgactg ccctaaaatc gcagaagcca 3411901 ctgcgttata cgattccaat cttcccatac cgtttacctt gctgagggca aggccgatat 3411961 atctaatgat aaacgggagg actttccact tttgcagaat cccgatcaga gcggaaataa 3412021 acacgattgg caagagaaca ttcataaaga atgtcgtttg gtccgcattc accaagccgc 3412081 caaacacaaa gttaattccc tctgccgcgt attcaagcag gtaaccgaat ccttttgcaa 3412141 atcctcccac gaggaaattc cctattccgg tattgaggag aatgtagcca agaataaatt 3412201 gcaaaatgag cataacaaca attgggcgga tcttaattct ttttttgccg ctgctcgcga 3412261 tccacgcgag gcctaaaaac acgattaaac cgataatccc aatcaaatac ttcatatgtg 3412321 tttctccttt atttgtattc gcttacaatt actgtttcct cagaaaacgg aaagcagtct 3412381 gccttccgtc agctcttaat agttgtctcc gcctgatgca ttttctcctt ttacgataga 3412441 aacgcctgcg ctggcgccaa ttcggcttgc tccggcctct accattgtgt ctacatcttc 3412501 tttcgttctg acgccgccag atgctttcac gccgatatca ggccctactg ttttgcgcat 3412561 taaggcgata tcttccttcg ttgcgccgcc tgtagaaaag cctgttgatg tttttacgaa 3412621 atccgctccc gcagacaccg ctaaacggca tgcacgttct ttttcttcat cagtcagaag 3412681 gcacgtttcg ataatgactt tgacaagcgc ttttccggct acagcttcca ctacaccgcg 3412741 gatatcagct tccaccacat cgtcttcctt gtcttttaaa gcggcaatat taatgaccat 3412801 atccacttca gtggcgcctt ttgaaatggc gtcttttgtt tcgaacgctt ttgtttcagt 3412861 tgtattggca ccgagcggga agccgatgac cgtacaaacg tcgactccag ttcccttaag 3412921 ctcttttgca gcaagctcca cccatgtcgg attgacacat actgaagcaa atttgtatgt 3412981 tttcgcttct tcaattagtt ttagaatgtc cgctttttgt gtatgcggtt tcaaagctgt 3413041 atgatcaatt atgttggcta atgacatcct tcgcacactt ccttttttgt taagatattt 3413101 tttagcataa ccgacttttg aacatatgta aattggtaat tgaaattttg ttcaatgaaa 3413161 ggtttgaacg tgtcacaaat cattaacaag cgccctcgcg gtatgctggt caatgattaa 3413221 aacgttggca tattttccgg ttaatgctcc gtgaatggaa gatacttttc tgcttccgcc 3413281 ggcaactaaa atggagcgtt ccttcagtct aaggtcttga agctcaacac cgatggtccg 3413341 gtcattgatg gcgctgctgc aaatattccc tttcgcatca aaaaagcgtg aacaaatatc 3413401 cccgacggcc tgttttttca gcagggcttt ctcttcttcg ttaaaatatc cgagccgaaa 3413461 caacagcgct tcatcacgga cagtcccgac cgtaaagaga gcgatattcg cctgcttgcc 3413521 catctcaatg atccgttcaa tatgacggtc tttctccacc attcgcttca catccgcatt 3413581 atcaaacacg acgggaagcg ggagatagcg cggcatcgtt tgaaaagcct ctgcaaacag 3413641 ctgaatcgtt tcagccgaat acgtgtttac ccgggaatgg ctgatgccgc ctttcagctg 3413701 gacgacctcg acgcctttta cctgcttcgg ctgcatgttt tgcgcgattt gatacatggt 3413761 ggttccccag ctgacgccga caatgtcgcc gtcttttacc gtttcatgca tatattctgc 3413821 accatagcgg cttaggtcat gtgtaattcc tgcataatcg ggtgtcgggg aaaacacaac 3413881 atgcgcctca aggagcccgt atttctcttc aagtatggaa ccgagcgcat ccaaatcctc 3413941 aaaagggtcc atgacgcgaa tctggacata ccctttttcc tttgcatatt gcagcagccg 3414001 ggaaacggtt ggccttgaaa tgttgagctg ctcagcaatt tgctgctgac tgtagtcaga 3414061 ctgatagtaa agccttgccg cttctatgct taattgctgt ttttcccgat ccattctgca 3414121 cctccctgtg gatcagtcct gataaaactg cttttgattt gcttttatta tacaggctgg 3414181 cgccggcttt catccacctg atttctaaga aactgaaaaa cgctctgggc gcggacctgc 3414241 ccagagctta cttctcccaa gtcggtttct ctgagcataa agttatttcg tttttcctaa 3414301 actcagcgga tctgtgatca tctcttttgg ctataaagtt tccgtttttt caaaacaaat 3414361 gtttcaaatg agataggaaa tgggtactaa tctattaact ttgttacata tttttagata 3414421 ctcattggct caacaactga ggaggagaca tttgtgaaga aagacacaag gaaatatatg 3414481 atctactttt tcggcgcttt agggggactg ctatatggtt acgatacagg tgttatctcc 3414541 ggagcactcc tgtttatcaa taacgatatt cctttaacga cattgacaga aggattggtt 3414601 gtcagcatgc tgctccttgg cgcgattttc ggttctgcct tgagcggcac atgctcagac 3414661 cgctggggca ggagaaaggt tgtatttgtc ctttccatca tttttattat cggtgcgctc 3414721 gcttgcgcat tttctcaaac aatcggcatg ctgattgcat ctagggtgat actcgggttg 3414781 gccgtcggcg gttcaacggc acttgtgccc gtgtatcttt ccgaaatggc accgacgaaa 3414841 attcgcggga cactcggcac aatgaacaac ttaatgattg tcaccgggat tttgctcgcc 3414901 tatatcgtta actacctgtt cacaccgttt gaagcgtggc gctggatggt cggtctggct 3414961 gcagtgcctg ccgtgcttct attaatcggc atcgccttca tgccggaatc gccaagatgg 3415021 ctcgtgaagc gcggcagcga agaagaagcg agacgcatca tgaacatcac tcatgacccc 3415081 aaagacatcg aaatggaatt ggcagagatg aagcaagggg aagcggagaa aaaagaaacg 3415141 acacttggcg tgctgaaagc caagtggatt cgccctatgc ttctgattgg cgtcggcctt 3415201 gccattttcc agcaggcagt cggcattaac acggtcatct actacgcgcc aaccattttt 3415261 acgaaggccg gtcttggcac atcagcttcg gcgctcggca caatgggaat cggcatcctc 3415321 aacgtcatca tgtgtatcac tgccatgatc ttaattgacc gtgtcggccg caaaaaactt 3415381 ctgatctggg gaagtgtcgg catcacactg agccttgctg ctttatcagg cgtgctcctg 3415441 acactggggc tttccgcatc aacagcgtgg atgacagtag tctttctcgg tgtctatatc 3415501 gtcttttacc aggcgacatg gggtccggta gtgtgggtgc tcatgcctga gctcttcccg 3415561 tccaaagcac gcggagccgc gacagggttc acgactttgg tgttatcggc ggctaacctg 3415621 atcgtgtcgc ttgtcttccc gctgatgcta agcgcgatgg gcatcgcatg ggtctttatg 3415681 gttttctcag tcatttgtct tctctcattt ttcttcgcgt tctacatggt accggaaacc 3415741 aaagggaaaa gcttggagga aattgaagca agcctgaaaa aacggtttaa aaagaagaaa 3415801 agcacccaaa accaagtgct gaatgagcgt acattataaa aaaaggaatc gtctccttat 3415861 gagacgattc ctttttctgt ttacaccatg accttgcaaa tattgttcgt aaattccaca 3415921 gggtcctgaa tcggcaggcc ttcgatgagg agcgcctgat tgtacagaag gtttgtgtac 3415981 aggctcagct tctctttatc ttgttcaaac gcgtcctgca gtgtttggaa tacctcgtga 3416041 tttgggttga tttccagcac tttttccgcc ttcacatttt ggctgtcagg catcgcattt 3416101 aagatttttt ccatctcaat tgtcacttcg ccgtcagcag caaggcagac tggatgtgat 3416161 ttaagccgtt ttgagattct gacgtttttc actttgtctg acagaatgtt tttcatttcc 3416221 tcaaacagat ccttatactt gctttcctct tcctcggact gcttttgatc ctcatccgtg 3416281 tctatgccaa ggtctccgct tgatacggac ttgaattctt tttcctgata agaagccagc 3416341 attttaattg caaactcatc gatgtcctca gtaaagtaga ggatttcata gcctttgtcc 3416401 gccaccattt ccgtttgcgg cagtttctca atgcggtcgt aagaatcacc ggtcgcgtaa 3416461 taaatgaatt tctgctcctc tggcattctg gaaacatact cgtctaagct gaccagtttt 3416521 ttctcttttg aagagtagaa taagaggaga tccttcaatt gatccttatt cgcgccaaaa 3416581 tcattgtaca cgccgaattt cagctgtctg ccgaacgact tgtagaacgt ctcgtatttc 3416641 tcgcggtctt ttttcaacag gctttgcagc tcgcttttga ttttcttgct gatgtttttc 3416701 gcgatcagct tcagctggcg gtcatgctgc agcatttctc tggaaatatt cagcgacaga 3416761 tcctcagaat cgaccatgcc cttcacaaag ctgaagtggt ccggtagcag gtctgcgcac 3416821 ttattcatga tcagcacgcc attggaatac agctccaagc ctttctcata ttccttggaa 3416881 tagtagtcaa acggcatgtt ttcagggacg aatagaatcg cgttgtagcg aaccgctcca 3416941 tccacgctga tatgaacgtg tgtcagcggt ttatcaaacc cgtaatgctt ttcagcatag 3417001 aatttttcat aatcctcatc tgtcagctcg cttttgtttt ttctccagat cggcaccatg 3417061 ctgttgaccg tctgctcttc ctgcacctct tcaaattcat tttcgctgcc ttccttcggc 3417121 ttattaatgg ttgtatccat tttgatcggg tagcgaatga agtcggagta cttcttgatg 3417181 atcgctttta aacgatattc ctctaaaaac tcgtcatagc tgtcatcttc tgtgttctct 3417241 ttgattttca ggataatgtc tgtaccgaca gaatcctttt cacacggctc aatcgtatag 3417301 ccgtctgcac ccgcagactc ccatttataa gcctcttcgc tgccaagcgc tttactgatg 3417361 actgtcacga catcggcaac cataaatgcc gcgtaaaaac cgacaccgaa ctgcccgata 3417421 atgtcatgtc cgtctttcag ctcgttttcc tttttaaacg cgagggaacc gctttttgca 3417481 attgttccaa gatgctgttc aagctcatcc tttgtcattc cgatccccgt atcagagatg 3417541 gttaatgttc tcgcatcttt gtcagctgcg acctttatgt agtaactgtc tttatcaaac 3417601 gtaagcgcat cgtccgtaag cgctttgtaa tagattttgt caatcgcatc actcgaattg 3417661 gagattaact cgcgcaggaa aatttctttt tgggtataaa tggagttaat catcatatcc 3417721 agcaagcgtt tagactctgc tttaaactct tttttcgcca ctcttgatcg ctcctttacc 3417781 attatgtaaa cccttttcag catctattta tcacataaga tgacaattgt caattagatt 3417841 gatagatgca tatatatgta aatttaacat tagttggatt tgttttcact ctttttctca 3417901 ctcattctca taaaaaagag aggcttcatc atcctctctt tttttctgtg tcattccaac 3417961 ggccaaactc ccgcttcatc catatatgca ccgggtagaa aaacaaaccg aacggtatca 3418021 aaaacaaaag attatgccat gaagcattca gaaatgcgct tgcagtcacc gggaacgtaa 3418081 tctcttgcaa taaaaaagag atgacagtca gcacaacaaa tgcagatgga atggtcacga 3418141 tgcaataaaa cttgagctcc ttcttatgct gtaccttcaa acatacaaac ctcccaacaa 3418201 tttctaattc atcttaacat atgctggcct ttcttttctc gcatgtttat cactgcacat 3418261 agcgggaaga caaatagaaa aaggaggtct cgtatcatgg gaagacttga aaacaaaaca 3418321 gcagttatca caggcgccgc gacaggcatt ggtcaagcga cggcggaggt ttttgccaat 3418381 gaaggcgcgc gtgtgatcat cggagatatc aataaagatc aaatggaaga aacagttgac 3418441 gcaatcagaa aaaacggagg acaggccgaa tcctttcacc tcgatgtgtc agatgaaaac 3418501 agtgtgaaag catttgctga tcaaatcaag gatgcatgcg gaacgattga tattctgttt 3418561 aataatgccg gcgttgatca ggaaggcgga aaggtgcacg aatatccggt tgacctgttt 3418621 gaccgcatta tcgccgtcga cctgcgcggc acattccttt gcagcaaata tttgattccg 3418681 ctcatgctcg aaaatggagg ctccatcatc aacacctcct ccatgtcagg ccgtgccgcg 3418741 gaccttgacc gctccggcta caacgccgca aaaggcggta tcaccaacct gacaaaggca 3418801 atggcaatcg actacgcacg aaacggcatc cgcgtcaatt ccatttcacc gggcacgatc 3418861 gaaacaccgc tgattgacaa attagcaggc acaaaagaac aggaaatggg cgaacaattc 3418921 cgcgaagcca acaaatggat cacgccgctc ggacgtcttg gccagcccaa agaaatggca 3418981 acagtggcac tgttcctcgc atcagacgac agctcatacg tcacaggaga agacatcacc 3419041 gcagacggcg gcatcatggc gtacacatgg cctgggaaga tgctgattga ggagaaatgg 3419101 aaggaagaaa cgaaataaga gagggagccc cctctctttt tgtcttttaa agcaatacaa 3419161 ccttatattt cttcacatcc aaaaactgca aaaactccct cgccagcact tcaggcggat 3419221 gcgcctttcc ttcatccagc cgatacaaaa gcaacccgat aatcattgcg gatacataat 3419281 gggcataaag ctttttctct gcgtgaatat cagtttgctg atgcagataa aacgattcca 3419341 gcgctttgaa catatcaggt atcacatgag gaacacccca ttcccgattg agaaaatgga 3419401 caatgggcat gtttgacaaa gcagaaagca gaatggcgag cgccttctcc gcttccttta 3419461 aggaaaattc attcgggctg gaggcaatcg tcaggtgatc aatgatctcc gcacatgatc 3419521 gctgtatcat ggtttggagc aattcctcct tattggcata gtgatcataa aaggttgcac 3419581 ggcggatatt gcttttacgc gtaatatctg aaatcgtgat gcccgcgtag tcttgtttct 3419641 ccgccaatac atccagaaat gccttctgca gcgcctctct cgttcgaacc acccgcctgt 3419701 cgatttgctt ctccttctct cgctctcctg gcacagcttt tccaaacagc caataaaacc 3419761 gcttttgaga aacaagctcc cataccttct ggctgatggc ttcaggagac gcggccgcat 3419821 cctcattcag ccaatacagg ataatcgcgt acgtgtacaa ggcccgataa tgtccataaa 3419881 tgtcccgttc aatcggcgtt aaattcacat ggatcggagc cagcagcaca tcctgctgaa 3419941 acacatcctt aaaaaaacga tgaaaatgtc ctctgttcat catcacagaa aaaaaggaac 3420001 gatgctcatg aacaaaggac agcgtcggat gcaccgtttg ccgttttttg ttcaaatgaa 3420061 gggtatccat atgactgaag gcgtcaaaaa gcgctttgcc cagtccttcc ttcatgtctt 3420121 cgatcacatc ctcaatgatt gaaaacttat cctcataata aaggtagagc gatccgcggc 3420181 tcactttggc cttctcagcg atttctttca ttgtgatgtg ttgaatatct ctatctttca 3420241 ataaagccag cagcgcctct ttcacttgag cttcggcaga ttccggcaca aaagacacct 3420301 ccaatcatta gacagatctt agatatatgt acggtaacgt atagatggtt caccgttgtc 3420361 tttcttacag aaaaggtacc accttataat aggtccgaga aaagaagaaa gcaaatgagg 3420421 gggattttac aatggaacag caagtaaagg acgacatcca gcgtgtcttt cagcttcaga 3420481 aaaaacagca aaaagccttg cgcgcttcaa cagcggaaca gcggagagaa aagcttcaac 3420541 gctttttaga ttccgtcatc gcccatgaag aagaaatcat cgaagcgatc cgcaaagacg 3420601 tccgcaaacc atatcacgaa gtcaaaaaag cggaaatcga aggaacaaaa aaagcgatta 3420661 gagataatat gaataacctg gaacaatgga tggcgcctaa agaagtcggt tcatcgttaa 3420721 gccctgacgc aaacggaatt cttatgtacg agcctaaagg cgtcacactc atcctcggcc 3420781 cgtggaacta tccgtttatg ctgacgatgg cgccgcttgc cgcttctctc gcagccggaa 3420841 acagcgcgat tgtgaagctg tccgatttca cgatgaacac gagcaacatt gctgctaaag 3420901 taataagaga cgcttttgat gaaaaagaag tcgcgatttt tgaaggagag gttgaggtgg 3420961 caaccgaact acttgatcag ccgttcgacc atattttctt cactggaagc acaaatgtcg 3421021 ggaaaattgt catgacagcg gctgccaaac acttggcatc tgtcacactt gagcttggcg 3421081 gcaagagccc gacgatcatt gacagtgaat acgatctgat ggacgcagcg aaaaagatcg 3421141 ccgtcgggaa attcgtaaac gccggccaaa cctgcatcgc acctgattac ctgttcatta 3421201 aaaaagacgt tcaggacagg ttcgcgggga ttttacaaac agtcgtcaac gctggattta 3421261 tggaggatga tcatacccca gaccgcagca aatttacgca gatcgtcaat gaccgcaact 3421321 tcaaccgcgt caaagatctg ttcgacgatg ccatcgaaag aggggcggaa gtggtgttcg 3421381 gcggcgtatt cgatgccagc gaccgcacga tctcgccaac cgttttgaaa aacgtcacgc 3421441 ctgacatgaa aatcatgcag gaggaaatct tcgcatcgat cctgccaatg atgaactatg 3421501 aagacatcga cgaggtcatc gattacgtaa atgaccgcga taaaccgctt gcactttatg 3421561 tgttcagcaa aaaccaagat ctgattgaca acgtccttca gcacacgaca tcaggaaatg 3421621 ccgccatcaa tgatgtcgtc gtccatttca gtgacgtcaa cctgccattc ggcggcgtca 3421681 acacaagcgg aatcggctcc tatcatgggg tatacggatt caaagagttt tctcatgaga 3421741 agggtgtatt tattcaggcc gctgaataat cgcatgatca aaaggcgctt ccttagagga 3421801 gcgcctttta ttgtaactcc ttgaccaaaa gcaattcatc acggataggt attttattat 3421861 ctgccagtaa aggaatttcg ggcttcatct ttctggccgt ctcgactgca ttcacaaata 3421921 gtcgatccaa ccggtaccct ctcttctgat aaaacgctaa tgcatgaata ttatcattgg 3421981 ttgtgatcag ttttatttgt ttgatatttc tctctctgca tgcttcctcg gctttctcta 3422041 gcagagctgt tccgatccct ttattctcaa tgacactatc cagcgaaatg atttcacagg 3422101 catcttcttc aaatatgtat gtaataaggc caacaatctg gttatcatcg ttgagcattc 3422161 cataaccatc taattcatcg cagttataaa taccgctaga aataaccatt tgcggactgc 3422221 cccagtgttt ttgaaaaaac gcggaaacaa gatctttagg tacctggcat gtcggaataa 3422281 tattcatatt ttcctccttt tagctgaaca aaaataagag aattaacaac ctattttatg 3422341 tcattaatcc ccttatctag tatttactag aacttataac ttgtcaaaag ctgtctgaat 3422401 accaattgcg tggattgata aggatcaaaa tctgaatcct gagattggaa gatttgctct 3422461 ggggtcaatg tctctgcgtt ctctgataac gtttgaatca gactttccaa atatccattt 3422521 aactctgatt tggacgattc atgtagggat tgatgattta cagcgagttc tctaaatctg 3422581 ttatcactga ttaatttttt tcgaagagct gctagcatca agtcaagcca tgcaggctgg 3422641 ccaaatgtaa tatttaaagc taacgttgct tgatcagatt tggtggagtg ccataaacct 3422701 cttggcaaat acagcatggt tcccggtgtt aaattaacga tttctgcatc tggcagatcc 3422761 tcttttggcg gatctccttt ccaatatgac tgtaaatcat caggatagta aggagcctct 3422821 gataaatcat agtgctgcat tggattgctc acattttcat tcttggcaag cttccatgtt 3422881 ttctcacctt gaatttgaaa aatcaagttg gtgtaggcgt caaaatgggc tttgaatccc 3422941 ccgccatttt tcgccgcgta aacaatggct ttggaagaag tacccgcagg cagtcttaat 3423001 tccgctttga gtttttctat ccaccttctg acttggggaa taaataggtc ggtgaaatca 3423061 aactctaatg cagccccttt ttcataccac tctaaagcct ctgcaggtga cacaagaaat 3423121 ctgtctgtga tcccttcaga ttcttcaatc acagcatcac caacgaccat gactggatta 3423181 ttgtagatag ccaatacgtt ttctagcgtt ctaacctttt caaaccccgg tatgcttgta 3423241 aatctctcca cttctcctct ggctaccaaa ggttttacag gccaatattc ttctaaaaac 3423301 tcactcatcg ttacaggact gatgatagac tccaaaaccg attcggttac agcactcata 3423361 ttatccctcc caaaaaaagt aacttcacca caaagatata acattttttt ctaaaagtaa 3423421 atattgacag aattatcaga ggattataat atttagttgt gcgtgatagc ctattttttt 3423481 acaaggaagg agggaaaagg atgaaaaagg cttataagaa acctcgtctt tttgaactgc 3423541 gccgtgctgt agcagctggc ggccattaat ctcatatagc atttgacatc tagtactcta 3423601 ttttaggagg gatgctcaat gaaaaaagct tataagaaac ctcgcctttt tgaactgcgc 3423661 cgtgctgtag cagctggcgg ccattaatct catatagcat ttgacatcta gtactctatt 3423721 ttaggaggga tgctcaatga aaaaagctta taagaaacct cgcctttttg aattgcgccg 3423781 cgctgtagca gctggcggtc attaatctta tccaaaacga ttaacgtttg aggctatcac 3423841 gccaacttga taaggaggat gctgaagatg attacggctg aagaatgcag aacgtacaaa 3423901 gaatttgttg atctttacca atcctatctt taccccttgc ttggcgccag actgtcccgg 3423961 atgtattccc ccaaaaacaa agtcattatc gatatgggca caggtccagg ttatttaagc 3424021 attcagttgg ctaaaagaac aaatgcgcac gtgcatgctg tcgatattaa cccggccatg 3424081 catgaaatcg ctcaagaaga agctaaaaaa agcggagtaa gcagcctgat ttcatttgat 3424141 ttggaagatg tccaccattt atcttacgct gaccaatatg ctgacttcat cgtctcctac 3424201 tcttgcctgc atcattggga agacgttgtt aaaggactta aagagtgcta tagagttctg 3424261 gctccgggcg gaaaaattgt cattttggat acatttaatc cccaaggaag ccatttagag 3424321 attatgcgaa aacaaatcaa agaaccggaa tacttcaggt ttgtaagaga ggcatttgaa 3424381 gaaagttatt cctttgaaga cattcaccag tttgttcagg atgccggcat tcccaattat 3424441 tcattagaaa cctttcactt tttaccggag gattttatag aaagcttaga tgagctggag 3424501 gatgctcccc tgtgggaaca aaatgatcaa agtactgatc atgaaattga gtctgtcaca 3424561 tggatgttaa cgatagaaaa agaaaaggaa ggtgcattgt aatgatcaat gaatcaactg 3424621 ttttatccaa aaatccagaa atgccatcaa gaaaatattt gaaaagcatt attatagagc 3424681 cgggcatcac tttaaatgaa atggcatcag atatttataa ccatatcgac ggcaaggtca 3424741 gcatacatga tatttgctca aaaatcgtca atgaatatga tgttgattat caaacctgct 3424801 tagaagattg tatggagctg tttgagttgc ttattgatca tgaagcaatc aaagttaagc 3424861 agggggcatg agaattggaa aaacaaaaag tgcttgcttt accagacgat gtacatgagc 3424921 tgagtacaca ccgttctaaa tcaatcgtaa attacatcat cactctgctt gcctttgcca 3424981 aaaaacaagg attgactcat caagatattg taagctggat tcacgagcaa tatgaggaaa 3425041 gaggatatta tgatgagtgg agacacatta acagccaaca accagttgga tcatttgtgg 3425101 aactctttat aaaaggaaga cgtttacttt atgacaaaat tgaattgttt gaaacagaag 3425161 ataaatatgt cgtaaatacc cacacttggt atgaaaaaga acctagtgag gccttttttt 3425221 attttgaaat tgatcccgaa gaattttctg cgtacgcttc cattctcgca atcgaaaacg 3425281 caaaacgtct cggaattaaa atcgatattg taaaagaaac agatgtagag acagcttata 3425341 tctataaaca tcaataacgc tattgggagg gagacatatg tgcgggctcg cgggtattat 3425401 aaatctggct gctccccgtt ctcaggaatg tacctttcat atattgaaag gcatggcaga 3425461 tgccatcagc tataggggac cggatgatga acaatatcat attgattcca aagtcggctt 3425521 tgcatttcgg cgattgtcca ttcttgacct tgtaaatgga cagcagccct ttttaaatga 3425581 ggatggatca atcgtcgtta tggtaaatgg agaaatttat aactataaag aactgaaggc 3425641 ttctttacac aatcatatgt ttaaaacgac atctgattgt gaagtaattg ttcatttata 3425701 tgaagaaaaa gggattggat ttgtagacga catcatcgga atgttttcaa tagccatttg 3425761 ggacaaaaat aaaaacaaag tatttttagt tcgtgaccgc tttgggatta aaccgctttt 3425821 ttacacagag ctaaaacacg agcttatatt tgcctctgaa ataaaatccc tattttctca 3425881 tcctcactgt ccccgccaat ttaattggaa agaagcactc tcagacattt ggctaagcgg 3425941 ggaagcagcc agtaatcata aagaaaccac ttcctttttt gtaaacatcc aaaatctcga 3426001 tgctggccat tatctcgaaa ttaatttgac aacaaatgaa cgaaaaacag caagctattg 3426061 gtctttacag gatattttgc tcaggcaagg ctatcgtgag aatctccatc ccgatgacct 3426121 gattgaagga tatagagaac tgctggcaga ttcagtccat agatgtttac aaagcgacgt 3426181 tgaagtcggg ttgtttctta gcggtggcat tgattcagct gcagtcgcac attttgctgc 3426241 agaaaaacag gatctccata cgtttacagt attaagccaa agtacattta caaatgaaga 3426301 tgcaaaatat gcccattggc tggctaaaga tttacacctt ccaaatcatc aggttctcta 3426361 tcaattaggg aacgatgagt tattacaacc agagtcatat aaacatttgt tatggatctg 3426421 tgaaacaccg ttttgcggac cggaacaatt atataagttt catttacata agtatgccaa 3426481 agcgataagg ccaaacctga aagtcatgct gaccggccag ggcagcgacg aatttaacgg 3426541 cggttacagc acgacacttt caccagccga gaacccaagt tgggaaggat ttattgaatc 3426601 ggtcaatacg atggagatga accggctgca tcggctgcag ggaaatatct ttagagtgtg 3426661 ggaggagcat tttggacttt ctcctataaa cctttcttat ttaaagagca atgattccag 3426721 ccaagcagat ccttggcaat cgtatgtcct gacaaaatac cgtgatctgc aaatgtataa 3426781 ttgctggcat gaagatcgga tcgccgcggc taatcatatc gaaaaccgtg taccgttctt 3426841 ggaccatcgg cttgttgaat gggtttgcgg aatacctgat ggactccgta aagacttgtt 3426901 atgggataag tcggtattgc gaaaatcatt aacaaatgag ctgcatacaa gctataccca 3426961 ccggccaaag gttccttttt tctatggtaa ggacgtgaga tatacacata aaatgatgtt 3427021 tcatcttctg aagaaaaaca attatcagct tatagaggag gccttctctc acagcgatgc 3427081 ctccagcata atacaggttg aacacattca tgccatcatg acatatttgg aggatgatcc 3427141 tgagtttaca aattttgaat ttttattaag actggtgaac atgggacttt tatcaaaaat 3427201 gactaaagaa accccttctg ttcaattaga cataaccagc catttagaat cgataacaat 3427261 aaaagactgg cactcacagg aaggtgatat tgccagtcgt ttaaatatct cagccaataa 3427321 gtgtgaagga caagatattt tggcgctaaa ccctggcgtc actctgttaa ggccggaaag 3427381 cgatagtgag cattgcatct acattgcgga agaaggattt attcagttta ttgtttcgga 3427441 ggaagacgtc ggagcttggc tgcatattct ctgcgatatt aatggaaaag acacacttca 3427501 tacgatttta gacagacatg gtgtcagcct tgaagaagtg gccaaatata ttcaagaagc 3427561 catcgaacac aatatcattt tgatcaaaca aaaaaatctg ccagaaggag catatagatg 3427621 agcatctttt attcgttttc cgcacttagg ggattagcaa tggggatttt ttcgcctatt 3427681 tggattcttt atctgatatc taaagattat gatttccttc agattggatt aatgggagcg 3427741 gtacttgaaa ttgctaagct tatatttgaa gttccttccg gcgtttttgc tgatcgttat 3427801 ggaattaaaa tttcaattgc cagttcattc tttttctcca tccttacatg ggccttcttc 3427861 ccttttatcg attcagctgc tatttgcata ctggctatga tcatatgggc tttatcagat 3427921 tccttaattt ccggttcttt tgaaacttgg atgagccgtg tcgcagggga agatcgattc 3427981 ggcaaagaaa tgatgaaaaa cacacaattg ctaatcactt ttttaattat tggaagtatt 3428041 gccagcgggt atttgtattc attaaatatc tattttcctt tcctgctcgt tatggtgatc 3428101 tacttattac tatttatttg gatgtctgta tttattaaag tcccttctgt ttccgaaaca 3428161 aatcatgggg atcagaacca acatgattcg ataaagatta tcaaagaaag tttaaaaatt 3428221 atctttaaca aaaaaagggt tcttttaatc gtcatagccg gtttctttac agccacagcc 3428281 tatgacacaa tttcccgtta ctggcagcct tttttgagtg atttaggctt ttcagaaaag 3428341 tcactgggat atatttttgc cctaggaggg tttaccgctc tcgttctttt gacattaacc 3428401 atcaggttcg aaaagaagat cgaaaaaaat ccatatctcg ctttaacctc attggattcc 3428461 atgggcatgg tcatgacttt tctattgtct agagcattca ggccgctggg cattccatgt 3428521 acagcgtttt tgcttgcaat tgaagatatt catcatccga tcgtaacaag ttacttaaat 3428581 aagtttttcc ccgattcata caagaacaca cttttctcgt taaactcagg ggtaggagca 3428641 attggagaaa ttctttccgg tgtcattttc ggcatcattt ccgcagcctt tgggctctct 3428701 gccatgtttg ttgttgtagc tgtatttcta ttaatcccta ttatccttta tacgatagtg 3428761 cctaagatta aagacaatga tatgaaagtt cagattgaaa aatcccagca agtgtaaatg 3428821 ttttgtatca cagtaagaag accttcttat taaaagaagg tcttctgcta ttctattcag 3428881 ttatttccca aaagccatca gcttcgtata acttccaata taaagtgttc cgtcctcagc 3428941 gagctgagga gaagacacga cgttgctgtc ggtttgatag ctccataatt cattgccgtt 3429001 tgcgtctgcc gcataaacct tcatatcatc tgacccgaaa taaaccgttc ccttcgcgtc 3429061 aatcagcggc gccgttctga cagggccgtc tgtgtagaat gaccagttca tatccccgtt 3429121 tttgctgatg gaaaacagct cgccgcttcc tgagccgatg tagatattgc cattatgatc 3429181 aatcgcagga gatgagctgg agaacccgtt tagcgggaat gtccatttca aactgcctgt 3429241 tgatgtataa gcatacagct gtccatcttg gttgccggca taaatgtttc cgtccttatc 3429301 aatcaccgga tatcctttaa acgcatttga cgtcgttctg gaccatttca cctgtccggt 3429361 tccggagttg atcgcataaa acacgtaatt atatgtgccg acatacacgg tgccgttttt 3429421 ggcaagcacc ggcacagagc tgacgacccc atttgttttc aacttccagc gctctgtcca 3429481 ggttgatttt gacgtcggtt tgatcgcgtg aacataatta tcaagtgttg agaaatacaa 3429541 cgtcccgtct gaaccgatca ccgtttcaga gcttggcccg ccgcttaacg gaaccgttgt 3429601 taaaatttct cccgtttctt tgtcaataaa ataaatcttt ttgtcatagg atgccaaata 3429661 gataacgccg ttggtcccaa gtacaggaga ttgcgtatat gtttttccaa gattgcccgt 3429721 cacccatttg actgagccgt ctggattaaa ggctttcatt tccccgtctc tggaatgaag 3429781 atatactgtg ccgtctccgt caatcacagc ccccgctcca ttttgcggag tcgttctgat 3429841 gtcgttttgc catttcagcg tcccgtctgt atttccggcg aaccggcttt cgcgtgacca 3429901 gttaaacatg gcaggcgcca tcgcttgtac atcatatctt cctggcaaaa agccagatgc 3429961 tccattattt tgagaaaaca ccgtttccgc cgcataagca gctgtcggct gaagcacttt 3430021 ggcagcgggc acatcagaaa cagcgccggc cgaaacagcc gccgccaccg cagctcccgc 3430081 aatcaaagct ttcatacgaa atgacttgac catcattgag acccccatta tatgtaactt 3430141 ctaatttgtg accatcataa catattcatc cattttataa atctatttca caaaaacatc 3430201 acaaactaga aaactatgta agagtattca cggacgtttt ttcagcaccc gatcgaaatg 3430261 cagccacaaa ccaaatgacg ttgacagcag ccgcagcgag actaactccc aaaacaaaga 3430321 tcacctcaga aagcagatgg tcactaaaga aactaaacat caagataaaa ccggccgaag 3430381 acaaatgaat caaaagcccg aagccgcaaa gcaccgccat gacatacctc attgcatcga 3430441 ctccgagcat ataaacgaga aatggaatga aatacaagac aaggatcata ccgacagctg 3430501 accacatgcc agctgaatta aactgattgg ccgccgctcc cgttccggcc agcggcgaaa 3430561 gtgaagccgc cacaatcacg gcgcaaaaaa gaaacgcaga aatggttgtc atgatcgcca 3430621 cgctattttt ttttgacatc aaactcctcc tttaatagaa atattaacct tttttattat 3430681 aagtaagttg aatgttatat tcattatatt tttaaaaaat tccagaatac atacacaaat 3430741 gctatgcttc tttctagtat atttatatag taaaaaacaa aggataaaag actcattttt 3430801 ctgtaatatc aggattttat caccatacca tattgcatgt acatgttttt caaagtatac 3430861 tattccagat taattcagag gagagagaaa aatacatgga aaaaccagca ggattttgga 3430921 ttcgtttttt agcttatttt attgacggca ttattgtatc tgttcctagt tatattattc 3430981 tatttattat caattctgtg tttgtagctg gggctgtggc aacaaaccct tacatgacgg 3431041 aagaagagta tttagtgaaa tacatgacgc ttgcattttt gcctactatg ctgatcatga 3431101 tcgtcatcag cgtgttatat tacgggctgc tcacagcttc taaaatgcaa ggcacacttg 3431161 gcaaaaaaat tcttggcctg aaagtggtca atgaacaagg tgaacgggtt tctgtcggac 3431221 agggaattgg ccgttacttt gcctatatct tatctggaat catcttttat atcgggttta 3431281 tcatgatcgc ctttggagag aaaaaaggcc tgcatgacat catttgcaaa acacgtgtcg 3431341 tgtataaata atagaaaaaa gtctagacgc caataggcat ctagactttt gttttctttg 3431401 caataggctg ccacgacaga tacgtagcgc ttctccacaa ccactcaaac ggccccatcc 3431461 gaaagacacg aagccaaagg tggctgaaga ccatttgaac ggcacaaaca gcaattgtaa 3431521 tgagcacacc ggcagcaggg tacacttttc catacaggcc caagccgtaa tgataaaaaa 3431581 tccaagtaca cacaatagac tgcatcaaat aattggtaaa tgccatcctc ccaacagcgg 3431641 agaatgattg cagcactgtt ctcactcttg ttttatgata aagatagaca accgttgtaa 3431701 catagaaaaa catgaggaaa ggcgcgccaa tcagcaaaca tatttcttta tccgttacac 3431761 tgtacagcac ctgggcgccg atgccgatga caagcccagc catccataat cgttttaatc 3431821 ctttgcgatg cttttccggt tcatgcaaat accgtgattt tgctgccgca gctcccagca 3431881 aaaacatgct gaaatatgga atggatgcaa agaagtagtt gagcggatta tacgtaagca 3431941 tgccattcga agacatgtaa acaagacggt cgtggatccg ctgttctgca atatccttca 3432001 ggctgccgct tccataaaca tgaatcgctt gttttgcctg ctgtgttacc gcttgtaccc 3432061 attcctgtcc gtttgattga tcaaaacttg tcaacatgaa cggaatggaa aacagaagat 3432121 acaaagagac cgcccatatc agcagtgttt tcggctttgc ttttcgaaac aagagcagga 3432181 caaatccgag cagggcatat tctgttaaaa tatccccgtc ccatatcaaa aaggcatgaa 3432241 tcgttccaaa caagagaagc gccattaacc ttctcacata taacggaaca aaccgtttcc 3432301 ctttgttttc tgctctctcc atcatgacaa ccatgccaaa tccaaataaa aaggaaaaca 3432361 ataaaataca ttttgtttga atgaagaatt tcagtatgtc tgcggcggca aaatcagctt 3432421 cagaccactt atccatgaaa aaattctctt ttccaagcat agacaaatac atatccggat 3432481 aactgaaatg tgccagattg acaaataaga tgccgaaaat cgccattcct ctcagcacat 3432541 caagcacacc gatccgctca tttgttaaag tcggctgtaa tgaagacata gccatcacgc 3432601 tccttttttc tgtaccttaa gggtaggaaa aaatgaagcg cggtaacatc gatttaggtg 3432661 tcaggccggc atgaaaacct tacaatcttg tcatctttat ggtttcatca cctttaaatc 3432721 taatgcttcg atattctgca aaatgcgatc aaagcgcaaa gcctgaggct cacatgggaa 3432781 gatgtggcct tcatacgggt cgcctaacgt ccggaaaaac ggttcaaata aaccaggaac 3432841 caatacgccc accatctttg tatagtgaga atcaaggcga taggagtgaa cggtatttgc 3432901 agggacatgc aggaaatctc ccggattcag ctgaatttcc tggccatctg tccacatcgt 3432961 catctggcct tcaaggcaat aaaatgtttc tgtatgatat tcatggtagt gatcaacgat 3433021 tcggtcacct ttagggcctt cagatgatac gacgataaac tggccatctg tatttttttg 3433081 tgcagccaca atgcggtgaa gctgatctcc agtcaacaga cgatctcctt ctccagattc 3433141 aagaacgtat ggaaccgctc catctggcag ctctgtaagt tccgctaatt tggccgaaca 3433201 tgcaggcttt gcttcatcta gaaatacaat gtccgctaca gcggctgctt ctgcaaatcg 3433261 ctcgtttgag acttcttcgc ttgcgtacgg cggatgttca gcgtgatcat acggattccc 3433321 aataacggaa tacaagtgcg ctacgtttcc tttcatcgtg taagacacca gtcttgttct 3433381 gtggctctgc atccggtagc tgtgcggtgt tcccgccgga atgttggcat aatcacctga 3433441 tattaataaa tagcgttcac catcaagtgt cagttccagt ttcccgtcca aaacgagaat 3433501 tccttcatgt gtgtccttgt ggacgtgaag cggaaaggca tctccttttc ccccggaaag 3433561 aagcacgatc tcaaacaaat cacctgtgct cctcccattc gccatcaccg tggcaacctg 3433621 tctgccgaac agatagcgct cgccttctcc gctccggagc aaataaggca ttttttcttt 3433681 aggcaatgaa tgtgtacata atgttttcat attatcgctt cctccaattt agaccagtct 3433741 atatattatc attcatttgt ctagaccgtt ctatataatt gtaggagaaa ggataacaaa 3433801 atgctaccct ttttttctca ccagcactgg tatttgttcg gcaatgagaa gaagaggcgt 3433861 tttgtcttta ttcgttaacg aaagcatgat gccgccctca atcatcgaat taatcagcgt 3433921 tccaagctga tttgcttctt cttctgcaaa tccgttttcc attaattttc tggcaaaaac 3433981 cgcttcccag cttttaaaca ccttcatgca aaccgtccgc agcggttcac tgattaacgc 3434041 tgtctcactc gccagcaaac cgactggaat acctttaatg ctttctgtgt tgtcaaattg 3434101 gctggctgtt tttttgataa aaagctgaat cgcttcaaca ggatcagagg attcatccat 3434161 gctttgctgt atcagatgtt caacgatctt acctgtatat gtaaccgctt caattgctag 3434221 ttcttctttg ccattcggaa aaaagtgata aagcgatcct tttggagcac cgctttcttt 3434281 tacaatctgg ttcaaacctg tcgcgtgata tccttgcagc tggaacagac gtgacgccgt 3434341 gtgaaggatt ttttcacgtg aatctcctct gctagtcatt aaaacattcc ctcctaggta 3434401 tggtagagcg acttatataa tataaaaaag aaccctgtga ttgtcaaaag gggtaagacc 3434461 cttccggatg gggtaatgta caaaaacagc gtctaggagg gatctctcaa tgacaatcga 3434521 tcattcagtc acaaatacag agcagcttga acaacagaac cccgccataa aaacaaagct 3434581 caaactgaaa aagcttaagg atcaggtgat cgtcattacc ggcgcttcaa gcggtatcgg 3434641 acttgtcacg gcgagaatgg cagctgaaaa aggcgcaaag gtcgtggcag cagcgcgaaa 3434701 tgaagaggcg ctgaaggagc tcactgatga acttaaggaa aaagggcacg acgccatatg 3434761 ggtaaaggcg gatgtcggaa aagaagagga cgtcaaccgc atcgcagaaa ccgcgatcag 3434821 cacattcggc cgctttgata catgggtcaa caatgcggcc gtctcgactt tcggacacgc 3434881 catggacgtc accgtcgaag acatgaagcg catgttcgac acaaatttct ggggacctgt 3434941 ttacggaaca agagcggctg tcaaacacta caccggcaga ggtgtgccgg gcgcactcat 3435001 taatgtagga agcctgttcg gagacagggg aacggtcatt caatccacat atgcatctgc 3435061 caaatttgcg cttcacggct ggacggaaag catccgaatg gagcttgaaa aggaacaggc 3435121 gcccgtctcg gtaacgctca tccacccggg cagaattgac acaccatata acgagcatgc 3435181 gcacagctac ctcgacaaac agccggctca ttaccgctcc atgatctatc cgccggaagc 3435241 ggtcgccgaa gcgatcctgt ttgccgccga acaccctaag cgcgacatgt acatcggctc 3435301 acaggccaaa gccatcgcca tgctgggcgc gctttttcct cgtctgaccg acagactgat 3435361 ggaaaaaatc atgtatcaca gccagcatgc cgaaagaccg tccaatccga gagaagaaag 3435421 cgctctttat gatgctggct gcggtatgca tgacagaggc acaaataaag gatggatgag 3435481 gtcaagaagc tactacacaa aagcgacgaa gcgcccaatt gtatcggcgg ctgttgttgc 3435541 cggactagtg gcttgggctg ccgccaaacg atgcagataa tctctgacca taagaaaaac 3435601 ccatgctgtt ccagcgaacc atgggttttt cagctgttaa tcgataaaag ccttgttcat 3435661 acgctgcagc agctcgccga acatctcttt ttcctgtgtt gaccattctt tcagcatctg 3435721 ttcataacgt tcaaggcgct tttgctgatc ggcttttaat agttgtttgc cgagttttgt 3435781 aatggtaaac aggctgactc tcccatcaga cgggtctgag aaacgataga tgagctcctt 3435841 tgcctctaat gcagctgctt gtcttgaaag agtagaaata tcaagcttaa acgattcagc 3435901 caattcctta acacgagcag gcccaaactc atccaattgt ctcagtaata agtacgaaga 3435961 tctctccaaa ttccctgttc ttttctccga ttgatccaga taaacagctc tcctgataaa 3436021 agtcgtcagc tcatattcaa ttaattcaac tggattttga ttttgcaatc gctctcgctc 3436081 cctattccaa tctccggcat tgacaacatc atatatactt gtataataca aatgtacatt 3436141 aactgaataa atacaagtcg ttatatgact aaatcaatta ttatacttgt atagtacaat 3436201 catataaaaa gaaagtaaag cgattcctca gaaccatcct agaagcaagc accagaaagg 3436261 aggaagctgt tctgattgga gagcagcact tgatgtgaaa gtcatacgaa ttattttgca 3436321 agtgttgata ttatatgtat tttttatgat cggggaagcc attcagcatc tgtttcattt 3436381 acccgtgtca ggaagcatcg ttggattggt attgcttctg atctgcttgg gcctccgtat 3436441 tgttcccgtc tccatcattg aagacggagc agggttttta ttatccttcc ttccattgtt 3436501 gttcatcccg gcaatgacag gagtgataaa ctatccgtct ctcatttcat tcaatggcct 3436561 gatgctgctg attacagtcg ttctcagcac catcgtcacg atcattgcgg ctggattcgc 3436621 cagccagcta ttagagaaaa aagcaaaaaa acgggaggag aaagagaaat gcagcaagca 3436681 tgtatcgcga tcattataat tcttttaaca gttgccgctt atttagcgat ggtcaaactc 3436741 tataagcgat tcccgcttcc atttctgatc cctgttctga caacgacaat tttgattgta 3436801 gcggctttga tgatgtttca tgtttcctat gaaggctata tgatcggggg gaaatggatc 3436861 aattctttgc ttgggccggc tgttgtggcg ctggcctatc cgctttataa gcaatggcat 3436921 atcattgtca aacattgtgt tcccatttta ggcggcgtcc tggtcggctt atgcatggga 3436981 atgatcagcg ggctgatctt cgcagaagca ttcgggattg atcatgatct cttattatcc 3437041 attctgccaa aatcgatcac aacccctgtc gctattcaga tcgccgccgg tcttggcggc 3437101 gtcccttcca tgacagtcgt atttgtcatg attgcgggct tttcaggcgt catcctcggg 3437161 ccgcttttcc taaaatggct tcgcatacgc agctccctag gacaaggcat tgcattaggc 3437221 agcgcctccc atgcactggg tacctccaaa gcgttggaat atggggaatt ggccgtatcc 3437281 atgagttccg tctccatgac gctttgtgcg gtgctcggct cattcttcgg cccgctcgtc 3437341 gtctggctgt ttcatattta acaaagaaag actgccccgg gggagggcag tctttttcgt 3437401 ttaagaagca aaaaaatcaa tcaacggctg aaagtcctta gataaatcaa cgtcattcgg 3437461 ttctgcttga agcaggcggt caatcatacg ctccagctcc tcaacatcat tcttatccgt 3437521 atattcaatg aagtttaagc tttcaagcca atcccgatat gaatgtttgg ctttgccata 3437581 gctgtttcca aagacaaggc aaggtgtttt ggtgataatc gagaaaatca tcgcgtgaag 3437641 gcggtcggta atcaccaatt tactggagcc gatgcggtcc agcatctcca taaaatgctt 3437701 ttcacgatca gcgtaatcga tggtgtctac cgtatccagc accgtatcgg tacgctctgt 3437761 gtaagttgtt ttttctgccc attgcttcat ctgtgaaata aaatcttcgt cagtcacttt 3437821 ctccttatcc gctcttaaaa taaagagaac gccgtcccgc tcgagctctc gcggcacaat 3437881 atccaaggaa agcaccatgt ccggtgtaaa gatcacattg gagttgaagg tctctttcac 3437941 aacatccagt gtttgcgtct cacgcgcagc aatcgttaag tttgtatttt gatggtacgc 3438001 atcctgtgtt tttttctttt ccttctgtcc ttcctctgta tcctcaaaat aaacggattg 3438061 tggcagagaa attgatttgt agtctttaaa cgccgaaaag acctttcttc tgtcttcctc 3438121 aatatcgaga taaaggtttc ctaaattccc tccgcctgta aagcagacaa tatcgtcttc 3438181 acgaatgatc tccttcacca gttcaatgcc ctcatccgtc gcataatcca taatctcaat 3438241 gtattcataa tacggaaaat gatttttgat aaatttctct tccgcatacg caatcgcttg 3438301 gtcgccaatg tttgtgtagc taggggaacc aaacaaaaat acttttcgtt tatcatttaa 3438361 cagagcttcc ggctccacat ttggcgcaat gccttttact agttttttgc ctttgatttc 3438421 ttgtacagtc atatctgcgt cctccttctg ggatgaattc ctcattgtgt gttaactgtc 3438481 tctacccaaa aagaaggatg gctatgcatt ggcatgtgca tcggctatat cagaaacatc 3438541 gttttcgcca atttgataga cgctgcaatg tcccgcgccg ttctttccat atattccgcg 3438601 gcatgttcaa acgcgtcttc tagtggcacg gctccgggga cgatgctgaa aagcgcatcg 3438661 attccgtgtt gatagacggc attactgtct cgggaaattg atcccgcaat gccgataacg 3438721 ggcacatcgt atgatttagc ggccttggcc accccgatcg gtgtttttcc atgaaccgtt 3438781 tggctgtcga ttcgtccctc gccggtaatc acaaggtctg catcctgaac gatactttca 3438841 aaatcaaccg cttcaaggac aatatcaatg cctcttttca ggtcagcctg aagataagtt 3438901 agcaggctcc atccaagacc gcccgctgca ccggcgccct ctgtatctcg gaaggttgat 3438961 ccgagcgctt tttctgccat atcagcgaaa tggcttacgt tctggtctag tacatccaac 3439021 atgtcggccg tcgcgccttt ttgcggcccg aaaacagccg tagcaccctt tggtcctgtt 3439081 aacggattgt ccacgtcaca ggcaacttcc agtttgacat tccgcaatct ggaatcaagc 3439141 ccgctcacat ctattgatgc aagctgagat aacgcgccgc cccctgggcc aatctcgctg 3439201 cctgagttat caagaagcct tccgcccaat gcctgaatca tcccggctcc cccgtcgttc 3439261 gtggcgcttc cgccgattcc gatgatcaat cgctccgctc ccgcatcaag agctgctccg 3439321 attaattctc ccgttcccct tgttgtagtg atgagcggat ttcgcttatc tacaggcacc 3439381 agatgcagcc ctgaagcagc agccatttca atcacagctg ttctcccatc tcccatcatg 3439441 ccaaagaaag ctctcaccgg ttcccccagc ggccctgtga caacttgctc tatgatcctt 3439501 ccattggtcg catcgaccag agattgaacg gttccctcgc cgccatccgc caccggcaat 3439561 tttctgtaat cagcacccgg aaagaccgat ttgaaacctc tttctatcgc ttcggctgcc 3439621 tccagagctg ataagctttc cttaaaagaa tcaggtgcaa tgatgatttt catccaaatc 3439681 gcctctttca aaacatgatt cacttaacct attgatctcc aatgtaccat aattgatctg 3439741 gaaatacata ccatgcaata tggtaaaaat ttaaataaaa attagaaatg aaagtgtttg 3439801 cataaaagaa atattcacgt tatcatactt gtatacaagt atactccttg agtgaggaag 3439861 gtgagtgtat gctagactcc aaagacctgt tgtatcccgc aaaatggctc tcaaaagcgt 3439921 caaccggagt tcgtgtcgca tacgagctga gaatgcggat cgtttcaggt ctgattgaaa 3439981 gcggtaccat tttatcagaa aatacaatcg ccgccgagtt ttcagtaagc cgttcgccgg 3440041 ttcgcgaagc gctaaaaata ctcgcatccg aaaaaatcat ccgcttagaa cgaatgggag 3440101 cggtcgtaat tggtttaact gagaagaaaa tcgcggaaat ttatgatgtg cggttactat 3440161 tagaaacatt tgtctttgaa cggcttgtca aaatagacat tgagccttta gttaaggatc 3440221 tcagcaaaat tcttgaaatg atgaaagtct caatcaaata tgaggatgct gacgaatttt 3440281 catttcaaga tgtgctgttc catgaaacga ttatccgagc gattgatcat tcatacattc 3440341 agatgatctg gaacaatcta aaacccgtca tggaaagctt tattctttta tcgatgcggg 3440401 tacggttaaa ggaaaagtat gaagacttca caaggatttt agataaccac gagctttata 3440461 ttcaagccat caaaacaaag gatagggcgc tgatgattca gtctcttcac caaaactttg 3440521 atgatgtgca ggataaggta gaagacctat ggctctcaca acaaatgctg gcaaaaggag 3440581 ctgaatacaa caatgactag ttatatgtta ggaatcgata tcggcacgac aagcacaaaa 3440641 gctgtgctgt tcagtgaaaa cggagatgtg gtacagaaag aaagcatcgg ctacccgctc 3440701 tatacaccgg acatctcaac agctgaacaa aatccggaag agatttttca ggcagtcatc 3440761 catacaacag cgagaattac aaaacagcat cccgaaaaac ggatctcttt catttcgttc 3440821 agcagcgcca tgcacagcgt cattgcaatc gacgaaaatg acaagccgct gacgccatgc 3440881 attacatggg ccgacaacag aagtgaaggc tgggcgcata agatcaaaga ggaattgaac 3440941 ggacatgagg tgtacaaacg gacgggaaca ccgattcatc cgatggcacc gttaagtaaa 3441001 attgcctgga tcacgaatga aagaaaagaa atcgcttcca aggcaaaaaa atatatcggc 3441061 atcaaagaat acatttttaa acagctgttc aatgagtatg tcatcgatta ctcattggca 3441121 tcagcgacag gcatgatgaa cctgaagggc ttggattggg acgaagaggc actgcgcatc 3441181 gcaggcatca cgccggatca cttatccaaa ctcgtgccga caaccgagat ctttcagcac 3441241 tgcagcccgg aaatagcgat ccaaatggga atcgatccgg aaacgccttt tgtcatcggc 3441301 gccagcgacg gcgtgctgtc caacctcggc gtcaacgcca ttaaaaaggg tgaaatcgcc 3441361 gtcaccatcg gtacaagcgg tgccattcgg acgattattg acaagccgca aaccgatgaa 3441421 aaagggagaa ttttttgcta tgccttgacg gacaagcatt gggttattgg gggacctgtg 3441481 aacaatgggg gcatcgtcct tcgctggatc agagacgagt ttgcctcctc cgaaatcgaa 3441541 acagcgacac ggctgggcat tgatccatat gacgtgctga cgaaaattgc ccaacgcgtc 3441601 agacccggtt ctgacggtct gctgttccac ccatatctcg ccggagaacg cgctccgttg 3441661 tggaatccgg atgtacgcgg ctcatttttc ggcttgacca tgtcgcataa gaaagagcat 3441721 atgatacgcg cggcattgga aggcgtcatt tacaacctgt acacggtgtt cttggcgtta 3441781 actgaatgca tggatggccc ggtaacccgc atccaagcga cagggggttt tgcaaggtcg 3441841 gaggtttggc gccaaatgat gtcggatatc ttcgaatcag aggttgtcgt tccggaaagc 3441901 tacgaaagct catgtctcgg cgcctgcatt ttaggcctgt atgcaacagg aaaaatcgat 3441961 tctttcgacg ccgtgtccga tatgatcggc agcacataca gacatacgcc gatcgaagac 3442021 tcagccaagg aatacagaac attaatgccg attttcatca atctatcaag attattagaa 3442081 aatcaatata cacaaattgc agattatcag aggggcttaa tcacacacaa atagtacatg 3442141 acatgaaggg gagggcatta ccatgccgtt aatcatcgtt gcacttggga tcttagcatt 3442201 actatttctg attatgggct taaaattaaa cacatttatt tccctgctgg tcgtatcgtt 3442261 cggcgtggca ctggcactcg ggatgccgtt cgataaagtt gtcagctcca tcgaagcagg 3442321 aatagggggg actcttggcc acatcgcgct catcttcgga ctcggtgcga tgctgggcaa 3442381 actgatcgcg gattcaggag gcgcacagcg cattgcgatg acgctcgtca acaaattcgg 3442441 tgagaaaaat attcaatggg ccgttgtcat tgcctcattc attattggga ttgcgttatt 3442501 ttttgaagta ggactggttc tattaattcc gattgtcttt gcgatttcaa gagaattgaa 3442561 gatttctatt ttatttctcg gaatcccgat ggtcgcggca ctatccgtca cacacggttt 3442621 cctgccgccg cacccgggac ctacggcgat cgccggtgag tatggcgcaa acattggaga 3442681 agtgctgctg tacggcttta tcgttgctgt tccgacagtg ctcattgcag ggccgttatt 3442741 tacaaagttc gcgaaaaaaa tcgttcctgc atcatttgcg aaaaacggca atattgcatc 3442801 actcggcaca caaaaaacat ttaaccttga agaaacaccc ggctttggaa tcagtgtctt 3442861 tactgcaatg ctcccgatta tcatcatgtc ggtcgcgacc attatcgacc tgcttcaaga 3442921 aacaatcggg tttgcagata acggagtttt agcttttatc agattgattg gaaacgcatc 3442981 gactgctatg attatttcgt tattggtcgc agtctataca atgggcatca agcgcaacat 3443041 tccagtcaaa accgtgatgg attcttgttc aactgccatt tcacaaatcg gcatgatgct 3443101 tttgatcatc ggaggaggcg gcgccttcaa acaagtgctg atcaacggcg gtgtcggcga 3443161 ttacgtagca gacttattca aaggaacggc attatcgcca atcattctgg catggctcat 3443221 cgcagcgatc ctgcgcattt ctctaggatc ggcgactgtt gccgcactaa gcacaacagg 3443281 tctggtcatt ccgttattgg gccattctga tgttaacctg gcgttagtcg tactcgcaac 3443341 aggagccgga agtgtcatcg cttcacacgt caatgacgcc ggcttctgga tgttcaagga 3443401 atacttcgga ttaagcatga aagaaacatt cgccacatgg acattgctgg aaaccattat 3443461 ttccgttgct ggactgggat tcattttatt gttaagttta gttgtatgaa attaagaagg 3443521 agctgtaaca catgttcaat tcgattggtg tcataggctt aggcgtaatg ggaagcaaca 3443581 tcgccttaaa catggcaaat aaaggcgaaa acgtcgctgt ctataattac accagagatt 3443641 taacggacca gcttatccaa aagctggatg gacaatctct cagcccgtat tacgagcttg 3443701 aggactttgt tcaatcgtta gaaaaaccaa gaaaaatctt tttgatggtc acagcgggaa 3443761 aacccgtaga ttccgtcatc caatcattaa agcctttgct tgaagaaggc gacgtcatca 3443821 tggacggagg aaactcccac tatgaagaca cagaaagaag atatgacgag ctgaaggaaa 3443881 aagggatcgg ctacctggga gtcggcattt ccggcggtga agtcggtgcg ttaacagggc 3443941 cttccatcat gccgggcgga gatcgcgacg tctatgagaa agccgctcct atcctgacga 3444001 aaatcgcagc ccaagtcgga gatgaccctt gctgtgtcta tatcggacca aaaggggcag 3444061 ggcactttac aaaaatggtg cacaacggca ttgaatatgc cgacatgcag ctgattgcag 3444121 aagcttatac gtttctaaga gaaacgcttc gtctgccgct agatgaaatt gcatctattt 3444181 ttgaaacatg gaatcaaggt gagctgaaaa gctatttaat agagattaca gctgagattt 3444241 tacgcaaaaa agacgaaaaa acaggacagc ctctgatcga tgtcatcctt gataaaaccg 3444301 gccaaaaagg caccggaaaa tggacgagca tgcaggcgat tgataacggc atcccgtcca 3444361 cgatcatcac agagtccttg ttcgcccgct acttgtcatc tttaaaagaa gaacggatgg 3444421 cagctcaaga tgtattagca ggcccggaag ccgaagaaaa acacttggat aaagacactt 3444481 ggattgaata cgtcagacag gctctttaca tggggaaagt atgcgcctat gcacaaggct 3444541 ttgcccaata taagatgtca tctgagcttt acggctggaa tctgccgctc aaagacatcg 3444601 ccttgatttt ccgaggcggc tgcatcatcc gcgctgattt cctaaacgtg atcagcgaag 3444661 cattcagtga gcagccaaat ctggctaacc tgctgatcgc gccttatttc acagataagc 3444721 tccatgccta tcaaacaggc ctgcgaaaag tcgtttgcga gggtatcagc accggaatct 3444781 ctttcccatg cttaactacc gcgctctctt attacgacgg ctaccgcaca gggcgttcca 3444841 atgcgaacct cttgcaggca cagcgcgatt actttggcgc tcacacgtac gaacggactg 3444901 atatggacgg cgtcttccat acgaattggt ctgaataacc tgtattaaaa acacggtcag 3444961 tttcaactga accgtgtttt tttcttctat cccaaacaac agaagacata agttatgttt 3445021 taaatatcat aaacagtgat acaataatag ctagaaacaa tccccaagat catcatgtga 3445081 cagcagattg ctgttccgtt ctattctgct tttggccatt gtcctttgcc cttgaccatg 3445141 gtgtcataaa atgttcaaat gccaaaacgg cctggcattc tgatttacaa aagtccctga 3445201 aaaccttatc taattgagaa tcagcctctc atttattata aaagaaatgc ctaaatccta 3445261 cctgtcacac ctttattaag atgaaaaaaa gtaggttatg gcttgacaaa aaatatatat 3445321 taattaataa ttcatatata attagaatta ttattgaaag cgattatgct ttctaataca 3445381 tttttaggag gaatatacat tatgtcttta atcggtaaag aagtacttcc attcgaagca 3445441 aaagcattca aaaacggtga attcatcgat gtaacaaacg aagatttgaa aggccaatgg 3445501 agcgtattct gcttctaccc agcagatttc tctttcgtat gcccaactga gcttgaagat 3445561 cttcaagaac aatatgctgc acttaaagaa ttaggtgttg aagtatactc tgtttctaca 3445621 gatactcact tcgtacacaa aggctggcat gacagctctg aaaaaatcag caaaatcact 3445681 tacgcaatga tcggtgaccc atctcaaacg atctctcgca acttcgatgt tcttgacgaa 3445741 gaaactggcc ttgctgaccg cggaacattc atcatcgatc cagacggcgt tatccaaact 3445801 gttgaaatca atgcaggcgg tatcggccgt gacgcaagca accttgtaaa caaagtaaaa 3445861 gcagctcaat acgttcgtca aaacccaggt gaagtttgcc cggctaaatg ggaagaaggc 3445921 ggcgaaactc ttacacctag ccttgatcta gtaggtaaaa tctaaggagt gcattcaatt 3445981 ggtacttgat gcaaatatca aagcacaatt aaatcaatat atgcagctaa ttgagaatga 3446041 cattgttctc aaagttagcg caggcgaaga tgacacttct aaggacatgc tggctctcgt 3446101 tgatgagctg gcttccatgt catcgaaaat ttcagttgaa aaagctgaat taaacagaac 3446161 gccgagcttc agtgtcaatc gtgtcggaga agacactggc gtgactttcg ccggtatccc 3446221 tctgggccac gaattcacat cattagtgtt ggcgttgctc caagtgagcg gcagaccgcc 3446281 taaggtagac caaaaagtca ttgatcaggt gaagaagatc agtggtgaat accacttcga 3446341 atcttatatc agcctgacat gccacaactg tcctgatgtt gtacaagctt taaacatgat 3446401 gagcgtgctg aacccgaaca ttacgcacac gatgattgac ggtgcagcat acaaagcaga 3446461 agttgaaagc aaaaacatca tggcagtgcc gaccgtttac ctgaatggcg aatccttcgg 3446521 aagcggccgt atgacgcttg aagaaattct tgcgaaaatg ggcagcggca cagatgcatc 3446581 tgagtttgct gacaaagagc cgtttgacgt tcttgtggtc ggaggcggac ctgctggtgc 3446641 aagtgcagcg atctacactg cacgtaaagg catccgaact ggtgttgtcg ctgagcgctt 3446701 cggcggacag gttctcgaca ccatgagcat cgaaaacttc atcagcgtca aagcgacgga 3446761 aggaccgaag ctagcggcaa gtcttgaaga gcatgtgaag gaatatgata ttgatgtcat 3446821 gaaccttcag cgtgcgaaac gccttgagaa gaaagatctg ttcgaacttg aactcgaaaa 3446881 cggcgctgtc ctgaaaagta aaacagtgat cctttcaaca ggtgcacgct ggcgcaatgt 3446941 caacgtcccc ggtgaacaag agttcaaaaa caaaggtgtc gcatactgcc cgcactgtga 3447001 tgggccattg tttgaaggca aagacgttgc ggtaatcggc ggcggaaact ctggtatcga 3447061 agcagcgatt gatcttgcag gtattgtcaa tcacgttact gtactagaat tcgcgccgga 3447121 actgaaagca gacgaagtcc tgcaaaaacg tctctacagc ctgcctaacg ttactgtcgt 3447181 gaaaaacgca caaacaaaag aaatcacagg tgatcagagt gttaacggca tcacatatgt 3447241 agaccgcgaa acaggcgaag aaaaacacgt tgaacttcaa ggtgtattcg tccaaatcgg 3447301 tctcgtgcca aacacagaat ggttagaagg aacggttgaa cgcaaccgca tgggcgaaat 3447361 tattgtcgac aaacacggcg caacaagcgt accaggctta tttgctgccg gcgactgcac 3447421 agacagtgcg tacaaccaaa ttattatttc tatgggatca ggtgcaactg ccgccctcgg 3447481 cgcgtttgat tacctaatcc gtaactaata taagaaatcc gctatattgc cagattggca 3447541 ggatagcgga tttttctttt tctacagaaa aaaaccgaac caggcactac ggtaaaagtg 3447601 ctcgattcga gcgcttctta tagttcctca ccattcgttt gaatgacatt tttataccac 3447661 tcaaaggagt ctttcttata tcgtttcatg gatccgtttc cttcattgtc acgatcaaca 3447721 tagatcatgc cgtagcgttt tttcatttcg ccagttgtga aggagacaat atcaataatg 3447781 ccccacggcg tgtagccaat taaatcaaca ccatcgtacg tgaccgcttt tttcaatgct 3447841 tcaatatgcg attttaaata ttgaatgcgt tccggatcat gaaccttgcc gtcctcctcc 3447901 agcgtatcca ctgcgccaaa gccattttca acgatgaata acgggatttg gtatcggtca 3447961 taaaaacgat ttaacgtata tctcaacccg gttggatcaa tcgcccatcc ccagtcactc 3448021 gaagtgatgt acggattttc gacaccattc ggcaagccgc catttacaat atcgccagtg 3448081 ttatcatttt tcacatcgct tttcacagtt gttgacatgt aatagctgaa gcctaagtaa 3448141 tcgacggttc cgtttcttaa aatctcatca tcgccgtctt cgaatgtgat gttgtagcct 3448201 tcgcgttcaa attccttcaa cgcgtagctt ggataataac cgcgaacctg cacatcaggg 3448261 aagaaatagc gctgcctcat ttcttcttca gccagcatca catcttcagg attggaggag 3448321 aaaggataaa tcggcacgtg tgataccatg gccccaatct ggaactctgg attgatgtct 3448381 tttccttttg ccactgctaa ggcgctcgcc actaattcat ggtgcgccgt ttgatacatg 3448441 acttccttgg cgttttcgtt ttcgccaacc acaacacctg aattcgtcca taggaacagc 3448501 ggattgttca catccatttg gttgttaatc tcgttaaatg tcatccagta cttcacttta 3448561 tctttgtaac gggtaaagca agcctctgcg aagttgacga agaagtccac gactttccgg 3448621 tttctgaagc cgccatattc tcttgccagg tgcagcggca tttcaaagtg agacagggta 3448681 atgaccggct cgatcccatg cttcagcaat tcatcaaaca catcatcata aaactgcaaa 3448741 ccagcttcgt tcggttcagc ctcatcgcct ttcggaaaaa tccggctcca gccgatggac 3448801 gtccgcagac attttaatcc catttccgca aacaaagcga tatcttcctt gtatctgtga 3448861 tagaaatcaa tggcttcatg gtttggataa aattcgtttt cttcaatcgt gtcagtgatt 3448921 tttctcggca cgccgtgcgc acccgctgtc atcacatcga cgacactcgg ccctttaccg 3448981 ccttgattcc atccgccttc aaattggtgg gcagctaaag caccgcccca taaaaaatcc 3449041 tttggcatgt ttcccatgtt taattcctcc tcagcttacg actgtaaata ttttttgatg 3449101 taatgcactt tcctcaatgt cttcaatgaa agctttatca aactcaacaa gcacttcgcc 3449161 ttttttgacg gtatcgcctt cttttacctt caaggaaaaa ggcgtgccgt caaatgtcac 3449221 cgtatccagc ccgatgtgcg caagcaattc gacgccggac gctgaacgca ggccaatcgc 3449281 atgctttgta ggcgtaacca tgacaaccgt aatgacgccg ggatggtagc atcgatttca 3449341 cgatatcctt cgctttaggg gtagaccgct tcagcaccaa tcgaagtctg gtagcgcagc 3449401 gagaagcccc aatcacattc tcttccccgc ctacggcctc taaaatgtct tttgctagtc 3449461 tcgtataatc tctcactttc cccgacattt cacccacccc ttcgttttgg ttacgctttc 3449521 attataattg taacggtata atttatcaat tccgaaacaa aatatttacg cactaactat 3449581 cattgtaagc ggtttatgct ataattttga caagtgaaac taaacgaata aatgaggaat 3449641 gcgtatgtta aaataccagc aaatcgcaac ggaaattgaa acatatatag aagaacacca 3449701 gcttcagcag ggagacaaac tgccagtcct agaaaccctc atggcccagt ttgaagtcag 3449761 caaaagcacc atcacaaagt ccctcgagct attagagcaa aaaggcgcga tctttcaggt 3449821 cagaggaagc ggcattttcg tcagaaaaca taaacgaaaa ggctatatca gccttctgtc 3449881 gaatcaggga tttaaaaaag atctcgagga tttcaacgtc acctcaaaag tcatcgaact 3449941 ggacgtgaga aagccaacac cggaagcggc ggaaaacctg aacatcggaa tggacgagga 3450001 catctactat gtcaaaaggg tccgctacat caacggccag accctttgct acgaagaatc 3450061 ctattacacc aaatccatcg tgacgtattt aaacaacgaa atcgtctccc actccatctt 3450121 ccattacatc cgggaaggac tggggttgaa gattggtttt tctgatttgt ttctgcacgt 3450181 gggccagctt aatgaggaag aagcggaata tttgggatta gaggctggac tgccgaagct 3450241 gtatatagaa agtatttttc acctgacaaa tgggcagccg tttgattact cgaagatttc 3450301 gtataattat gagcagtcgc agtttgtggt acaggctaat agttttttat tatagggctc 3450361 ttcactacgg taggtggtcg acatgtacaa aattatcatt cctgccatac tagccatctt 3450421 tgcgctctgg atactcttac agatttcact agagatgagc atcgttaaga atccaatgaa 3450481 ctactttatc gtattcatta tctttttcct ctttgtaaag atggtgaaag aaaaacaata 3450541 atagtttggg cgatgcaaac agaaaaacat ccttccctta acaaactcag ccagtcacat 3450601 gcattaatct tgatgttaat gatatatagg tgcacataaa aagctacttc attgtgaagt 3450661 agctcccttt attaaaggcc cattttgatc catctagttt tagaaaagcg aaggacaatc 3450721 gcatttatga taataattga aactaaatac aaaataataa ataaaacatc attactccca 3450781 agtgtcatgt tatcagattg cagcactctt tctattcggg ggtacatagt gttacctgcc 3450841 tcaaaaggag caatgaaacc aaacgtttta ttgcttatag ctactaagat aacagaagtc 3450901 atccaataaa cgatactgac acctatacta attaatatat taggacataa cacgcttata 3450961 gttccgataa ttagaatata ctgcagtata actgcagaaa ataaaaaaag taataatgca 3451021 aaatgcgaaa aatcatggta catcaacgat atgattagca ggcctagcgt tataaatgca 3451081 aaacattcta aaaataaaac agctatcttt ttataaaaga aagtatagat gttctctcca 3451141 attaacttgt aaaagagaat atttttgttt gaatactctc tattaataaa gaaagctata 3451201 acaaatgaaa ataacatcaa accaaactgg gtcgcaacag tataggagct aaagaaaaac 3451261 atttcaggtg taacattact gactttatcg attccaacaa gtaaaaaata acccagcaaa 3451321 aataaaaata caaacattgc tcctaaaata atgataactt tgttgctaat actcttttta 3451381 aactctaatt tcatctcaag cccccactgt tttattactc atttatatac acttcaatta 3451441 atttatccac tgaatgatat tgttgaattt cttggtgatt aaatatataa taatcccctt 3451501 ctatcgcctt taaatcagac aaatcatgtg taatgttgat gataatcttc tcggggttct 3451561 cctgaatata cttgtttaag aagccatgaa tctctataac cgtttttttg tctaatgaat 3451621 tcgttatttc atctaaaaca ataatatttt tatcctctaa taagaaactg agcaatttta 3451681 atttttgctt ttgtccatca ctcaaatttt tgatcagaac ttttccatca atattatcca 3451741 gattaagtaa atatgcgatt ttatctatca tttttgcatc aaatttttta ctcaaaaagt 3451801 gtaataaaaa gtccttagaa acatcattag gtatattcga cgagctggat attaaagaaa 3451861 cattttgacg aatatctctg ccgattcttt tgctattatt caacaaaaag tctttagcaa 3451921 gctgtgattt accgactcca ttttttccga caacgtgatt aattttcccg ctcgaaaaat 3451981 gcaagtcggt gtcctgaagt aacgttttgc ctttcacttt taaagtgtaa ttcgctatat 3452041 tcatatacat actcctagga aatatttgca taataataaa atgttctgcc ttgtgatttg 3452101 ttactaatgt ctaagctttt gaggtacctc tttcgtttcc gatccggaag cgaaagaaat 3452161 gtttttagat ggctaatttg gagatctttt actctagttt acaatatata atatccaatg 3452221 tacaactgaa ttcactgcaa ggccaatccc tataatttga atcgtaagaa ctaaccaatg 3452281 atttgtctta aaacggctat attcatctaa gctcagaaaa gctaaaagaa ttttgtaacc 3452341 atcagaattc aatattggga ttaagttcca caataaagta gacgagaaaa gcataaatgc 3452401 catagttaat gcttcactgg aaaatgtaaa ttgatttatt aattctaatg tatttattaa 3452461 aagataattg ataaacaagc caaataaatg aacgattatc ttttcatttc ttgatagcat 3452521 gtaggtttca ttcaattgga cataaaaagc aggaaataca taaaaattca gtttgaatcc 3452581 cactttatca aagtttttcc cgaaaaattt taaggaataa atatgtccca gttcatgaag 3452641 cactatattc attataaaat aaataactat aattatccac attttccagc cgtaaaatac 3452701 tgaggacaat ccattttgca attttattaa atgaatataa tttaatatga acatgagagc 3452761 cgtaaaggat aagaacagat aaaaaaactt tggtgatact ttctctttat acattttaaa 3452821 acgtaataat tgtttatctg acagagaatt taaactattt ttatagtatt ctccgctttt 3452881 tttgtctttt ataaatacgt tgttttgcac aagcacttca tatttttcat cttcatactt 3452941 taaaattttc attatagtat ttttccatat aaggatagaa gtagtttatt ttttctgcag 3453001 agttgaataa ggaaccacaa actccacaaa tagaggaaaa ttcataagga atgtcaaatt 3453061 cctctatttt gttattttct tttaaaatat tcaaaaacca tttgaatcct tcttttctaa 3453121 gaataaataa tagcaaattg gaatttaact tttccacggt tctttcgaaa ctttggttat 3453181 attcttccct tagggttatt ttcgtttcaa aaatagcagg ggaacaacat ggataaattt 3453241 ctccatcatg atgatataca atgtcatatc cgggacaatg taaggaatct tcatcttcaa 3453301 gactgtaaaa tttatgtatg ttttcttgct taattctagt tttagcagcg ccaactgata 3453361 tcattggaaa ttttgttatc tttacaccta agattgaatc ccccaattcc tctaaaatgt 3453421 ggttggacat tttgtctttg gtaactgcca tattaagaga aatatcgata tcagggtatt 3453481 tcctgctatg ttctaatatg tttttaatac tggaagactt gacaaatgga gcatggtact 3453541 catcataact tatagtcagt gctatcacat ttaaagaatt catatcatga aagtactcct 3453601 ggaccttttt cttgctcaaa ccccaaaatc cattagagat caacgttatt tgtttttcat 3453661 atggtttaat gatttccatt agttctttta aaaatttata atctaaaaaa acttccccac 3453721 ctgtaaaaga aatcacttga atggttttgt tttttgcaaa ttcagttact aactctctta 3453781 tgtattcttt ttccatcctg gttgttgaag ttggtgaact agaaaaacaa caatggtcac 3453841 aggatgcatt acaccttgaa tctaaattga ttgatactgt tttattatac atgaaatatc 3453901 ccccaacaaa tggtaaagga gagttagact ctcctttgta cccctctaat taatgaccac 3453961 ttccaagaat ccagcgattt tcttttgatt ttacaaaata ccaaagatca ttcacttttg 3454021 ctaacttttg tgattcatct aatagaccct taaattctaa gtttttcaca gtctcattgt 3454081 tagtgatttc ctttttcata ttatccctcc tccttttcta atataaacca attattctat 3454141 atcattcaat acatgtcaat atattgtacc taaaaaatct gaaaaatgtc actattcttg 3454201 gtatataaag cctatagtcc tctagcccct ctaagctata ccgaatgaaa ggccatagtt 3454261 tgatttaaag cttcgtaatg aaaagtaaaa catcaatatt gactacacta gttaagggat 3454321 atacagattt taagtggaag aaatgaggca aacaatctta ccctaaacca acctgtactg 3454381 aaaagctgtt ttaagctctt gcttacccca tttggcacct ctttctctcg ttttaattgt 3454441 ctctaaaagc agttatgcgg tactatcata taaaggtcca atgtttaaaa ataatgtcat 3454501 acttttaaat tcaccttatc atgcacatgc tcataaagag gggtttattc taaaaagggg 3454561 atggacggtt ttggaaagca agtacctaga tctactcgca caaaaatacg attgtgaaga 3454621 aaaagtggta acagaaatca tcaatttgaa agcgatattg aacctgccaa aaggcaccga 3454681 gcattttgtc agtgatctgc acggagagta tcaggcattc cagcacgtgt tgcgcaatgg 3454741 ttcaggacga gtcaaagaga agatacgcga catcttcagc ggtgtcattt acgatagaga 3454801 aattgatgaa ttagcagcat tggtctatta tccggaagac aaactgaaat taatcaaaca 3454861 tgactttgat gcgaaagaag cgttaaacga gtggtataaa gaaacgattc atcgaatgat 3454921 taagctcgtt tcatattgct cctctaagta tacccgctcc aaattacgca aagcactgcc 3454981 tgcccaattt gcttatatta cggaggagct gttatacaaa acagaacaag ctggcaacaa 3455041 ggagcaatat tactccgaaa tcattgatca gatcattgaa cttggccaag ccgataagct 3455101 gatcaccggc cttgcttaca gcgttcagcg attggtggtc gaccatctgc atgtggtcgg 3455161 cgatatttat gaccgcggcc cgcagccgga tagaattatg gaagaactga tcaactatca 3455221 ttctgtcgat attcagtggg gaaatcacga tgtcctttgg atcggcgcct attccggttc 3455281 caaagtgtgc ctggccaata ttatccgcat ctgtgcccgc tacgacaacc tggatattat 3455341 tgaggacgtg tacggcatca acctgagacc gctgctgaac ctggccgaaa aatattatga 3455401 tgataatcca gcgttccgtc caaaagcaga cgaaaacagg ccagaggatg agattaagca 3455461 aatcacaaaa atccatcaag cgattgccat gatccaattc aagcttgaga gcccgattat 3455521 caagagacgg ccgaacttta atatggaaga gcggctgtta ttagagaaaa tagactatga 3455581 caaaaatgaa atcacgctga acggaaaaac atatcaactg gaaaacacct gctttgcgac 3455641 gattaatccg gagcagccag atcagctatt agaagaagaa gcagaagtca tagacaagct 3455701 gctattctct gtccagcatt ccgaaaagct gggccgccat atgaatttta tgatgaaaaa 3455761 aggcagcctt tatttaaaat ataacggcaa cctgttgatt cacggctgta ttccagttga 3455821 tgaaaacggc aatatggaaa cgatgatgat tgaggataaa ccgtatgcgg gccgtgagct 3455881 gctcgatgta tttgaacgat tcttgcggga agcctttgcc cacccggaag aaaccgatga 3455941 cctggcgaca gatatggctt ggtatttatg gacaggcgaa tactcctccc tcttcggaaa 3456001 acgcgccatg acgacatttg agcgctattt catcaaagag aaggaaacgc ataaagagaa 3456061 gaaaaacccg tattattatt tacgagaaga cgaggcaacc tgccgaaaca tcctggcaga 3456121 attcggcctc aatccagatc acggccatat catcaacggc catacacctg taaaagaaat 3456181 cgaaggagaa gacccaatca aagcaaacgg aaaaatgatc gtcatcgacg gcggcttctc 3456241 caaagcctac caatccacaa caggcatcgc cggctacacg ctgctataca actcctacgg 3456301 catgcagctc gtcgcccata aacacttcaa ttccaaggca gaagtcctaa gcaccggaac 3456361 cgacgtctta acggtcaaac gattagtgga caaagagctt gagcggaaga aagtgaagga 3456421 aacgaatgtg ggtgaggaat tgttgcagga agttgcgatt ttagagagtt tgcgggagta 3456481 tcggtatatg aagtgagggg tgtggggttc agggatggtg atatgcgctg agaaaatgat 3456541 tggataaatg aaaaaccccc gcgggatgcg ggggttcaat ttaacgaaag aatcctaaaa 3456601 cggtttgtag ttttaggatt ctttcatctt ttcagcgtga ttgaaaaccc ttgaagtcta 3456661 ggaagaacga gcattggagc gcagcgaatg tttggaattc gtgagcaccg aagcgcaggc 3456721 ctgacaacga atgcgagggt ttgtcgacac gctgaaaccc ccgcgggtgc gggggttttc 3456781 ttattacagc agcttcttcc ctaacaggga ttctacgagc tctactgctg ttttgcccgt 3456841 tttgtttttg tgatcaagga tcgggttaac ctcaacgaat tcggctgagg taatgatgcc 3456901 tgcgtcatac agcatttcca tagccaaatg gctctcccgg tagctgatgc cgccgacgac 3456961 aggggttccg acacccggtg cgtcgttcgg atcaagtccg tccagatcaa ggctcagatg 3457021 gacgccatca catgctgata aataatcaag ggtttcttca atgacctttg tcatgccaag 3457081 acgatcgatt tcgtgcattg tgtacacctt catgccgctt tccttaatgt acttgcgctc 3457141 cccttcatca agtgaccggg cgccaatgat gacgacgttt tccggtttga ttttaggcgc 3457201 gtagccttca aggttaacca gtgactcgtg gccaatgcct aggctgaccg cgagcggcat 3457261 gccgtgaata ttgcccgatg gtgaagtttc aagtgtattc aaatcgccgt gcgcgtcata 3457321 ccagatgacg ccgagattat cgtaatgctt cgctgtgcct gcaagcgtgc cgatcgcaat 3457381 actgtggtca ccgcccagga caagcgggaa ttttttctct tcaatgactt tgttgacctt 3457441 ttgcgcgagt ttttcatttc ccgccaaaac ggaattcagg tttttcagtt cctcgtcatt 3457501 tttgattttt tcgcgattga tcggaatgtc accgagatct tcaaccgtat accccatgtc 3457561 tgacagcctc tcgatcagat gagcgtaccg gatggcactc gggcccatat ccactccgcg 3457621 tcgtgcttgt cctaaatcca ttggcattcc aataaccgaa atcgttttat ccatctgtga 3457681 ttccacctca acatttaaga taatgtccta tgcgggttat aacaaagatg acttgcggac 3457741 aacgttttta aagctctagc tgacgatttg cctgctggcg ttttttaatg acgacatgat 3457801 aaatgatgta gcaaatgatc ataaacggta cgccgcaata cagcgcgata cgctgctccg 3457861 gatcaaatgc aagactgatg agcacgaccg tatttaacgt taggccgatc agcggaagca 3457921 ccgggtacag cggtgtttta aatttcaaat cttctatctt cccgccctca cggatatatt 3457981 tgcgtctgaa catgatttgg gaaagcgaga tcgtaatcca gccgacctgc gcgctcatgc 3458041 ccgccaaaga taacagtacc atatatacgg tttcagcctg cgcaaacttt gtcagaagtg 3458101 ataggcaggc cacagccatc gttacgatta acgagtacat cggtacaccg cgctgatttg 3458161 ttttgccaag cgctttgaag gcttgtcctt cattcgccat cgcgtacaga atacgtgttg 3458221 atgcgtataa acctgagttc gcaacagata acagtgcgat taaaataaca aagttcatga 3458281 tatcagctgc atatgggatt ccgatttgct caaatacggc aacaaatgga ctttccacga 3458341 cacccgcctg tttccacgga atcatgccgg caatgacaat gattgaaagc acaaagaaca 3458401 caagcgttct ccatactgtc tgtttgatgg accgcggaat cgttttttca gggtcttcac 3458461 tttctccggc tgcaaccccg atcagctcag tcccctgaaa cgcaaagttc acagtaatca 3458521 tcgtaatcag cattgccttt atgccgttcg gaaataaccc gtcttcataa aaatgtgtca 3458581 aaaacggcgc ctgctctccg cccttcagat caatcaggcc aaacatggca gctccgccga 3458641 gaataataaa taaaaggata atcaaaattt taatgcctga gaaccagaat tcagattccg 3458701 caaaggcttt tgtggtgatc gcatttaaaa taaacatcag tgccgcaaag accagacacc 3458761 agatccacac gtctatatgc ggaaaccagc gttgcatcag ctgccccgct gataaaaatt 3458821 caatggcgca tgtaaccgcc cagccgagcc agtacagcca gccgaacgca aacccgaagg 3458881 ccgggctgat aaatttcgtg gcataggtct ggaaggaccc cgacacagga aaggcgactg 3458941 ccagctctcc taagcagagc atggtcaaaa acatgataaa gccgcccact aaataggaca 3459001 gaaccgcgcc gagcggtccc gcttggttaa tggtaaaccc ggttccaagg aagaaaccgg 3459061 ttccgatcac tccgcccaat gaaatcatga acaaatggcg tgatttcatt gtccgctgga 3459121 gctgatttcc gttatcttgg tttgtattca cattctgcac cccttcagca acttgtattg 3459181 gatctaagct ggaacatctg catggtgcta tcccagtttg ctgtccaaag agtctctatc 3459241 tatttaatat aaaattcact tcttctcata aagatacatt atactaaaat actgtagctg 3459301 agcaaatagg gagtgctgat ttttctgttg taaatttata caaacgaagt gaatatcccg 3459361 ccatggtgcg gatttatgcg tttcgcagca cgtgcttaat tttctctatc gcccaatcca 3459421 agtcctcttt ggaaatgatt aatggcggtg caaaacgaat gactgtatca tgcgtttcct 3459481 tgcataaaag tccctcttcc ttcaaacgct cacaatacgg acgtgccgct tcagtcaatt 3459541 ccacaccgat aaacagccct ctgccgcgga cttctttaat gacagggctg tcaatactct 3459601 caagctcgct tttaaagtat tcaccaagtt caagagaacg atccgccagc ttttcatcct 3459661 ccagcacttc taatgaagcg atagacactg cacatgcaag cgggtttcca ccaaatgttg 3459721 agccgtgtga gccagggtta aacacgccta ggatctcgcg gtccgccgca atgcaagaga 3459781 tcgggaacac accgccgcca agcgctttgc ccaagatata catatccgga acaatgccgt 3459841 cccagtcaca ggcaaacgtc ttgcctgtac gtccgagacc cgtctgaatt tcatccgcaa 3459901 taaacaagac attctcttcc ttacaaatcg ccgccgcttc ctgtaaaaat ccttcaggcg 3459961 gaatcacaat gcccgcttcg ccttgaatcg gttcaaacaa gaatgccgct gtattcggcg 3460021 taatggcctg tcgaagcgct tccacatcgc cgtaaggaat gagtttgatt cctggaagca 3460081 tcgggccgaa tcctcgttta tattcctctt cagaagaaag agataccgcc agcatcgtgc 3460141 ggccgtggaa gttcccgaca catgcgataa tttccgcttg attgtcagct acgcccttca 3460201 cttcatacgc ccagcgtctc gccgctttca ccgcggattc aaccgcttcg gctcctgtat 3460261 tcatcggcag aatcatctct ttgcctgtca gtttagctgt tttttcgtaa aacggcccaa 3460321 gctgatcgtt atgaaacgcg cgtgacgtga gggtgatttt atcagcctga tcctttaatg 3460381 cctgaatgat tttcgggtgt ctgtgcccct ggtttaccgc agagtaagca ctcagcatat 3460441 ccatatattc attgccttcc gggtccttta cccaagcacc cagcgcttca gaaataacaa 3460501 tcgggagcgg gtgataattg ttggctccgt aatgagacgt ctgatcaata atttctttgg 3460561 atttagataa agctgtcata tttgaattcc cccttgtttt ctgtttcaac atgttatcct 3460621 gctttccctt tatataaatg caagttctgt gccaaatcaa gaattcgtgt gttttctaca 3460681 attttcgagg acaaggtgca aaaacattct gatatttcga gcgaaaattt cagcaagtgc 3460741 aaaattcttt tgcatatcct ctccgttttt ttataaaata gaagcaatat taagaaaata 3460801 attgagggag gttcatacag tggtcaaaga cagcgaattc ctcacattgg tttttcagag 3460861 tattttagat gaaatcgatg ttggcctgca cgtggtagac gagcatggaa acacaatcgt 3460921 ttataacaat aaaatgatgc agattgaaga tatggagaag catgacgtct tgaataaaaa 3460981 cctgatggat gtgtttatgt tttcaaagca gcaggacagc acactggtac aggctcttca 3461041 ggaaggcaag acgattaaaa acgtcaaaca gagctatttc aataataaag gccaggaaat 3461101 tacgacgatc aatcatacat atcccatcgt ccaagacggc aaaatcaggg gcgccgttga 3461161 aattgccaag gatgtgacaa agctggaacg gctgatcagg gagaatatga acaaaaaagg 3461221 cagcacaacc tatacgtttg acagtattct cggcaccagt ccggccattc aagacgtcat 3461281 cgaaaacgcc aagcgggcaa cccgtacgtc atcatctgtc cttctagcag gcgaaaccgg 3461341 cacgggaaaa gaactgttcg cgcaaagtat ccataatgga agcgatcgtt ctggcggccc 3461401 gtttatttcg caaaactgcg cggcactgcc agacagcctt gtggaaagca ttttgtttgg 3461461 gacgaaaaaa ggcgcgttta ccggcgctgt cgaccagccc ggcctgtttg aacaagccca 3461521 cggcggcaca ctgctgttag atgaaatcaa ctcgctgaat ctcagccttc aggcgaagct 3461581 gctgcgcgcc cttcaagaac ggaaaatcag gcgcatcggt tcaacaaagg atacaccgat 3461641 tgacgtacgt attattgcca cgatgaatga agacccaatt gatgcaattg caggcgaacg 3461701 aatgcggaag gacttgtatt acaggctgag tgtcgtcaca ctgatcatcc cgccgcttcg 3461761 ggaacgaaaa gaagacattt tgcttctcgc gtcggagttc atccagaaaa acaaccatct 3461821 gttccaaatg aatgttgaac acatcagcga tgacgtgaag caatttttcc tttcttatga 3461881 ctggccggga aatattcgcg agcttgagca tatgatcgaa ggcgcaatga atttcatgac 3461941 ggacgagcaa acgattacgg cttcccatct gccctatcaa taccgcatga aaatcaagcc 3462001 ggctgacatc ccagagccgg aaacaccaag acaccagcca gccgcggact taaaagaaaa 3462061 aatggaaagc ttcgaaaaat atgtgataga gaacgtgtta agaaaacacg gccataacat 3462121 ctcgaaagct gctcaggagc ttggcatcag cagacaaagc ctccaatatc ggctgaagaa 3462181 attttctcac tcgtctaacg aataatccgg agcaggaagc ctgatcagaa aaacagtgcc 3462241 tctgccgatt tcacttttca cttcaatcgt cccattgtga ttgtcgataa tcgatttcgt 3462301 tatggcaagg cctaatcccg aacctccata tttccgggag cgggatgggt ctgccttgta 3462361 aaaccggtca aacactaaaa aacgtcactt cttatgcatt gaagaaagaa aatggcacct 3462421 atgtgtatca cagccagcaa ccacacggta caaaccatta aagtccatgc aaataacgga 3462481 agtatttgca gctaactgcc atttgctgtt tcacgtgtaa catccatctt gtatttttct 3462541 tcatattcga tatatccttt ttcaactgaa cgggcgtgac ccctgttcag ttttttttgc 3462601 atatcaaaac agcctggcaa cgatgccaga ctgcttttat taactgccta attggtctgc 3462661 ggaggacagc ttgatatcaa cagatttttc ttttccgccg cgataaaact tcaccttcac 3462721 ccggtcaccg acttttttct gataaagccg ttttcgcagg tcaacaatat catttacttt 3462781 gtatccgtca aattccgtga tgacatccag ttccttcagc cccgcttttc cggcaggtga 3462841 aaaggcgtct acacccatca caaccgctcc attggtgacg ttcttaggaa gctttaatgt 3462901 ttcatcccaa tgatagcttg cgatgtcact tagcgatttc atctcaatgc caaggaacgg 3462961 gcgtttgacc tttccgtatc tctctaaatc ctctatcaca gggatcacga gcttagacgg 3463021 aatggacagg ccaatccctt caaccgctga ctcggcaatt ttcattgaat tgatgccaat 3463081 gaccttccca tccatattta acaaagcgcc gccgctgttc ccagggttaa tggccgcatc 3463141 tgtttgcagg acttcagcgt tccagtcagg ctgtccatca ccgtttgaat ctactgggat 3463201 cgccctctcc gtacccgaga tgacgccttg tgtgacagag cctgcaaact caaggcctaa 3463261 cgggttcccg atcgcaataa ccggctcccc agacttcact ttatctgaat ttccgaaatc 3463321 agcgactgct ttaatcttat cgcttttcac ccgtaaaacg gcaaggtcca tcagctggtc 3463381 gctgccgaca agatcagctg atacacgtga gccgtctttc aagctgattt caatttggga 3463441 agcgccttcg atgacatgat ggttggtcac gacataagcg gaatggtcat ttttcttata 3463501 gatgacgcca gagccgctcc cagcctcgcc gctctctccc caaatatctg atttttggat 3463561 gttcacaaca ccgacaacgg cgggcgacat attgctgaca atcttggtga cggcattgtt 3463621 gacactgaca ttcaccgtcc tgattgattc ccggccattg ttgttttgct gctgatctaa 3463681 ggcgcctgta tccagccctt catttgaaag gtacggcatg ataaacgcca ttaatacggc 3463741 accgacaatc acgccaatca gactcgaaag aaaatatcct tttttgcttc tctttggctg 3463801 ttcaggagta gtatgttctt cctcacgttc gtaatccacc atattccatc ctttccaaga 3463861 acgttaatat ggttatattg tgggttagaa actcctagaa tagtcatgat ttacatagaa 3463921 aaattataca gcgcaaagcg gagtggcctt cttcggatcg gtgtcgtata agtcaaatgt 3463981 ctcacccgtc acaaatcctt tagaagccaa tgtctgctgc acagacattc ttgccagctc 3464041 cttcatgttg ttgtcctggc tcaaatgcgc caggtaaata cgagacgtct catcgccaat 3464101 gacatccgtc atcgccaagg cagcatcttc atttgacacg tgcccgacgt cacttaaaat 3464161 ccgccgctta atgctccatg ggtatcttcc catttgcagc ataccgacat cgtgattgct 3464221 ttcaaacaca aatacattcg ctgaacggat aatgcctttc atccggtcgc tgacatatcc 3464281 cgtatctgtc attaacgcga gctttcggcc gctataatgg aatacataaa acatcggttc 3464341 cgccgcatcg tgggaaacgc caaacgattc aacatcaagt ccgccgaacg acttcaccgt 3464401 ctccattgga aatacaaact tttgatcggt gtcaattttg ccgatttgat tctccatcgc 3464461 tttccaagtc ttctcattcg catagatcgg aagcttgtac tttctggcga cgacaccaag 3464521 gcccttaata tggtcactat gctcatgcgt cacaaaaatg ccgtctacat catccagctt 3464581 acgcccgatc tgcgccatca gcccatccat ggcttttccg ctcaaaccgg cgtccactaa 3464641 aaatgcgtga tcctctgttt cgaggtaaaa cgcatttccc gtactcccgc tcgcaagtac 3464701 gctaaattgc aagctcatgt ttgtctcact ccattatttt cattgatctg tatctaaaat 3464761 cgtactctcc aaagcattca cagtaaaata ctcttgtact gtctttttct caccgttcac 3464821 ttttttctcg tactcgaccg taattctcca taccggcgcc agcacctgcg tacttgtcag 3464881 cggatattgt gctacatagc cgaatttaca gctcttcaca gtgctgtatt cttttaattg 3464941 attttgatag tacaatagct caaccgcatc catttcagta attaagcttt ctttctggat 3465001 ttgcttgaag gtctcaagcg tagtctggtc gtatgacaca acctcgtttt taccgtttaa 3465061 gtgcagcacc acttgcccga tcatattaga gggattgtcg gtcttttggt aaatataatg 3465121 accttcgtac gtttggaaga aaataatttc tttcttcgat ttatcaacct tccaaagctt 3465181 atatttttcg ccatcttgaa ttttcgaaga aacaagtgcc tgagcatcgt cctcgatatc 3465241 cttctttgat agtgcgattg gatttgcaaa cttcattttc aggctcgtta ctttatgatc 3465301 atcactaggc atgtccatca aaggcttttg atccttcagc gcctcaattt cctccttgga 3465361 gaaagacttt tgatttgccg tgatccgata gccttctgtt gcttccttat tcaagccttc 3465421 atacgtgata tgatcggcct tcatgtcatg ctcgacatca tttttaatga cttcatattc 3465481 tttgccggta gcctgccatt tttgaaaaaa ctgatagcct aagaaaatat ctaaaatgag 3465541 gaaggcaacg atgaagattg attttgtctt attccactcc actgttagcc ccctccttcc 3465601 tcaataaatc ctttgtaatc ggcacaattt ttccatttac tttcatcgcc caaaccggtt 3465661 ccagttcaac gagaggatca tcgttggttg atgttgatac caattgataa gcaaggaaga 3465721 tctgatcaat tttgtccgta tcataagcgg tttgtttcga aagcagcatc ttcacttcgc 3465781 tgccgcccat gagctctgtt tcacttgttt taatcggatt cgttccgaga ctgtaattcg 3465841 gccgcttata gctgagaata tcatcattcg cccattgcac cgtaatcgcc gatgtcgccc 3465901 cgaaaggttt ggcggtgctg ttaatgaccg ggatctgatc cataaaaata tagaagctca 3465961 actgctggct gtcattgata ttgaaaaatt gatagtgatc cgtccagctt ccggtatcct 3466021 caaggtattt ttggctcttt ttgattaatt cacctgtttg ataggatgtg ctctgcacca 3466081 aattgcgctg ctgaaattgc acctgtctct ggcttagatt cacatctaac cggctgatcc 3466141 catctgtcag cacatttctg ttggtgtaat tcgaatcttc tcttacaatg ctcggatcac 3466201 taaacaaagc ctgcttaaag gtatttgttt taatcgattc tgtgacaaat tcttttttgt 3466261 ccatcgtaag cggtttgttc ggcagcaaga actctttctt tgagccaatg gagaacaaac 3466321 tgaacgccgg catatttgat tgcctgtttt tcaagtcgtt cataatgttc cggtagtttg 3466381 ctgattcaac cgtcacttca agaatgagct gcttgctgta tgacaccaaa tagattttct 3466441 tgttcgcttt tgtttcattg aacgggatca gaatatggtc aaacgaactg tattcaaacg 3466501 actgattaga ccatttaaac agcgtttgga aaatatcaat cgggatcgta tcgctgaatt 3466561 gcaagtcaag cttggcttca gaaccgccta ttccataaaa ccagcttttg aatccagcct 3466621 tgtcatactg atccgaaata tctttaattc ctttcacatc ccaatgcggc aagtcagacc 3466681 aaatttcttc atagagggca ttgtcatcca ctttgtaatg agcgccgtca tcatggataa 3466741 acatgtccct tggccttacc gtttcagaca gcttttgggt ggttttttcg attttatgtt 3466801 tcacacgaac agtagactct gttgaggatg agccttcaga aaagtttggc tggaacgtcc 3466861 atatccccca tgtaaaaaca agactgatga cgacgagtac cgtaagtaat atcgttttta 3466921 tattttcacg cttcatccca atcatcctct tgttcctctt tatatggaag agtaaatgta 3466981 atcgtcgtgc cttttccttc tatgctgtcc gcccaaatat ctccaccgtg cgcctgtacc 3467041 atttccttgg caatcgccaa tcccagaccg gtgccgccaa gctttctcgt tctcgcttta 3467101 tccaccctgt agaagcggtc aaagactttt tcgacatctt ttttcggaat gccgatccct 3467161 tcatccttca cgctgatata gagaagttct tcctcttcat tgacatcaat cgagaacgtg 3467221 acatgtccgc cttccggtga atattttaaa gcgttagaaa taatattatc gagcacctgc 3467281 gttattttat cctggtcaat ctcgacatac agatctctgt ccggcagatt gcggataaac 3467341 tccacatgct gctcttttgt catttcaaaa cggtcaataa taagtgacat aaaccggaca 3467401 atctgaatcc attcccggtt aaattgataa tctttactgt caaatttcga cagctgaagc 3467461 agatcattga caagccggat catacgctct gtttcatttt gcgtcaccat taagaagcgc 3467521 ggagcaatgt ctttattttc ccacgcgcct tcagctaacg cttctaaata gctgcgcatt 3467581 gtcgtaagcg gcgtccgcag ctcatgtgat acattcgcaa cgaattctct gcgttcctga 3467641 tccattttct cttgttcggt tacatcgtaa atgacagcga ttaaaccatc aattttgccg 3467701 tgttcccttt gaatcacaga gaaattcacg cgaagcaccg ttaattcatc atcgcgctca 3467761 atttcaagca gcatagaatc ctgctgttcc actaaatctt caaaagtata attctcttga 3467821 agccccagca aactcgtaat cggcatttct aaggctgttt cacgtgaaac gttcaacagt 3467881 tccagcgccg ggctgtttaa gagaataatc gctccgtttc ggtttgtggc gataacgccg 3467941 tctgtcatat aagcaatgac agaggctagc tttctgcgtt ctccttcagt catcgcctgg 3468001 gcatcttcaa gctctctcgt taagtggtta aacgttgtgg ccagctgccc aatttcatca 3468061 tgtccatact ttttaacctt cctcgagaaa ttccctttcg caagctccat cgcctgcttt 3468121 cgcatatctg aaagcgggtg ggtaatggtt cttgccagaa aaataccgag aagagccgtc 3468181 aaaacaagtg ccaaacctgt gccggacgcc agtatcgtgt tgatcgtctt catttgatta 3468241 aagacatctt ccatactcgc gacaacgtag atcgcgccca caacctcttg gttttcagtc 3468301 atgacgggct tcgcggaaat aagaactctg attttgcttt tcgggtcata atattttctt 3468361 aaatacgact gtttggtaga aaagattctt ttgaaaatca gatcggtcgt ttgtttccca 3468421 gccacttcct caccgtacgg ctttgaagaa ccgaccactt catagctttt atctacaaag 3468481 ctaatttccc gaacctcatc acttttcgtg aagtcattca aaatacggct gacgtcatcc 3468541 tttatgacgg tactgtcgtt atcgctctta tattcttgtt cgatataata agaaaggttg 3468601 tcgattcgct gattcagcga ttgttcataa gagctgatca gcgacttctc tacctgattg 3468661 acaaaataca caccaatgat ttgcatggca atgataatca aaagcacata aatcaaggta 3468721 atcttaaatt ggatcgaccg aaaaaaacca accttattca tatgggcatt agtcctgttc 3468781 tgggtttctc aagtaataac ctacaccacg gcgtgtgacg atccaatttg gatggctcgg 3468841 gttgtcctcg attttttcac gaagccggcg gactgttacg tcaaccgttc tgacatcgcc 3468901 gaagtaatca tagccccaaa cggtttgaag caaatgttca cgggtcatca cttgtccgat 3468961 atgttttgct aaataatgaa gcaattcgaa ctcacgatga gtcaattcga ttgtttcgtc 3469021 tcgttttgat acaacgtacg cgtcagggaa gatgacgaga gagccgatat gaatctcgtt 3469081 agaggaaggc tcttcctccg caggcgctgt tgtcagctgg cggcgcaggt tcgcttttac 3469141 acgcgccaag agctcgcgtg tgctgaatgg ttttgtgaca tagtcatcag caccgatttc 3469201 aagcccgata accttgtcaa tttctgaatc cttagccgtc agcataatga ttggcatatc 3469261 gtatttcttt ctgacttcgc ggcatacttc aacgccgtct ttatttggga gcataatatc 3469321 taaaagaatt aaatcaggct gaagctcttc taccatttca acggcttcgt ttccgtcgtg 3469381 ggcacagtgc acttcatagc cttcttttct taagttaaat tccaatatat ctgcaatcgg 3469441 tttttcatca tctactacaa ggatcttttt atccatcatt ttgattttcc tcctgccgaa 3469501 tgacttcatt tcatctatat aacattcgtt tcatcactta tggcccatgt aaagaatggg 3469561 tccttgtcta ttataacggt ttaaggtcaa aagataaaaa aaataaaggt ttagaaaaaa 3469621 aacacatgtt tcacctttat cgccagttgt ttatctattg tcatgctggt caactttttt 3469681 taaaaaagat aactttattg aaacctcccc tcaccggagt gcgtctttat caatgacgtc 3469741 ttcttctttg aaccggccgc agggccggtt ctcccttttt cttctattat aacactcctc 3469801 atgtttgcct ttttcctaaa agaaaaaacg cacctacgat tgcagatgcg tttggtaagt 3469861 ggctcgggac ggaatcgaac cgccgacaca cggattttca gtccgttgct ctaccaactg 3469921 agctaccgag ccaaatgttt tatttttctc tactaagtaa agtaaaatgg cggtccggac 3469981 gggactcgaa cccgcgacct cctgcgtgac aggcaggcat tctaaccaac tgaactaccg 3470041 gaccttacag taattgcccg gagagctgtc gtgtcagctc tcacagacaa ataaggaatt 3470101 tagcaataac gctaaagtaa atcaatgacc cgtacgggat tcgaacccgt gttaccgccg 3470161 tgaaagggcg gtgtcttaac cgcttgacca acgggccttc acgaaatggt gagccatgaa 3470221 ggactcgaac cttcgaccct ctgattaaaa gtcagatgct ctaccaactg agctaatggc 3470281 tcttaaagat gtcggaattt ctatagagca aacgacttaa atctagttct catcttgtac 3470341 tctattgaag cagtttccgt aacaacgaga tttataatat cacgaacaaa tagaagtggc 3470401 aataactttt ttggtttttt ttcatatttt tttctcagac caacttatat gcggctttca 3470461 aacaaaaaac aagcccctta aataggggct tgcagacata ttctatttag ttcgcacggt 3470521 acacactgcg aaggacattt gtttgtgagc ggtctggacc gacagagaaa atagaaagcg 3470581 gaatgcctgt cagctgagac acacgctcaa gataatggcg cgcattttcc ggaagctcgc 3470641 tcaagctctt cgcacctgta atatcctcag tccagcccgg catttcttca tataccggct 3470701 cacattcagc aagtgcctta agacttgctg ggaattcttc aatgatttcg cctttgtagc 3470761 ggtacgccac acagattttc aacgtttcaa ttcctgctag gacgtcaatt gagttcagag 3470821 aaagatctgt aattccgctc acacggcggg cgtggcggac aacaacgctg tcaaaccagc 3470881 cgacacggcg cgggcggcct gttgttgttc catattcgcg tccgacttca cggatttgat 3470941 cgccgatttc atctttcagc tcagtcggaa aaggaccgtc gccgacacga gtcgtatatg 3471001 cttttgatac accgacaacg tgcttgattt tggtcgggcc gacaccagaa ccgatcgtga 3471061 caccgccggc aaccgggtta gatgacgtaa caaacgggta tgttccttgg tcgatatcga 3471121 gcataacccc ttgtgcgcct tcaaataata cacggcgccc ttcatcaaga gcatcgttta 3471181 agacaacaga tgtatcgcaa acatactttt taatctgctg tccgtactca taatattcgt 3471241 ctaagatatc ctcaagttta aacccttctg tctcgtacat tttctcgaga agacggtttt 3471301 tttcttcaag attgcgctca agcttttccg caaacgcgtc acggtctaac agatccgcga 3471361 tgcgaattcc gatgcgggct gctttatcca tgtaagcagg gccgattcct tttttcgttg 3471421 tgccgatctt gttagcccct ttacgctctt cttccacttc atccaatttc aaatgatacg 3471481 gcagaatgac gtgagctctg ttgctgattc tcaggttatc tgtactcacg ttgcgctcat 3471541 gaagatacgc aagctctgtg actaatgctt tcggatctac aaccattccg tttccgatta 3471601 cacacgtttt atccttatag aaaattccag acgggattaa gtgaagctta tatgtgattc 3471661 cgtcaaactt gattgtatgc cctgcgttat ttccgccttg ataacgggcg atcacttctg 3471721 cattttctga taggaaatct gtaattttac cttttccttc atcgccccat tgcgtaccta 3471781 ctacaactac tgaagacatg tccgtgcacc tccgttaacc tttcaaaacg attctattca 3471841 aacaaatcaa gtttatcagt gaagaaacag aaagtcaatt gtaaatccga acattaattt 3471901 attgtaaatc tatattcgtt cgcttccatt cgttttataa gcgttttctc actgctttgt 3471961 cataaaaagc ttgcgaaact ttcatccttt agcataagaa agaatcactt gcctgatatc 3472021 ccttttgaat tcataaaaac gatccgccag ccgtccgggt cctctatcgt cacgccccca 3472081 ttgctccagt acgggttctc tgattcgacc tcttgatagc ccatgtgctt tagctttgaa 3472141 gtgatcgctg ccagttcaac tgcattcggc acataaaaaa caagaaggct gtcgggatgg 3472201 ggaacggggg cagtgcttcc cccttcatac tgggtgaatt ccaaatgata atcggcatga 3472261 ggaaggccga acatgacacc gtcatacccg ttatgctgtg aaaattctcc tattcgtttc 3472321 aaacacagtc cctcttcgta aaaacgaata atctcatcaa gctggcccgt aggacgcgca 3472381 attcggattt gtgctgcttg aaaagacgaa aaacgttttc ccatattgtt accatctcct 3472441 ttttgcacca ttttattaaa acgctttcaa tttttcatcc gctgagcgaa cgtcatttct 3472501 tccatctttc gaatgaaaaa aaccccaaga gcagctcttg gggcttatgc gccgggcgga 3472561 acgcctgcgt catcaaaacg ccgttccagg ttgacgaatt tgttgtattc ttttacgaac 3472621 gcaagagaca cggttcctac cgggccgtta cgctgtttgg cgataataat ttcgataata 3472681 tttttattct cggtttcttt gtcatagtag tcatcacgat aaaggaacgc gacaatatcc 3472741 gcgtcctgct cgatacttcc tgattcccgg atatcagaca tcatcggacg tttatcctga 3472801 cgctgctcaa cacccctgga aagctgagaa agcgcgataa cagggacttg cagctccctc 3472861 gcaatcgact tcagttcacg ggaaatttca gatacttcct gctgacggtt gtcctttgaa 3472921 cgaccgcttc cctgaatcaa ttgcaggtaa tcgatcaaaa tcatgcccag cccgctttcc 3472981 tgcttcaagc ggcggcactt ggcacggatt tcactcactc gaatacccgg tgtatcatcg 3473041 atgtaaatcc cgctgttcga taggcttccc attgccatcg tcagcttgcc ccaatcctct 3473101 tcggtcaggt tacctgtacg gagattctgg gcattgatat ttccctcggc acagagcata 3473161 cgcataacga gctgctcggc acccatctca agactgaaaa tcgctacgct ctcatcggtc 3473221 ttcgtcgcca cgttttgtgc gatgttcagg gcaaaggctg ttttccctac tgaaggacgg 3473281 gcagccacaa tgatcaagtc gttgcgctgg aaacccgcag tcatccggtc aagctccgta 3473341 aaccctgttg gaattcccgt gatatcacct tttcgattgt gaagctgttc gatattatca 3473401 taggtctgga caaggacgtc cttaatattt tggaaggcac tcgtgttttt gcgctgtgcc 3473461 acttccataa tcgttttttc cgcttcactg agtaaatcct cgacctcatc ctcacgggta 3473521 tacccgtctt gagcaatcgt tgtcgcagtt ctgattaatc ggcgaagaat cgatttttcc 3473581 tcaacgattt tcgcgtaata ttctatgtta gccgctgtcg gcaccgagtt tgcgatatct 3473641 gtcaaatatg aaataccgcc tacttcttcc agcaggtctg tgttcgcaag ctctgatgta 3473701 actgtcacca gatcaaccgg ttcacctcgg tcaccgagca ccagcatcgc attatagatt 3473761 ttttggtggg acattctata gaaatcatct ggaatcaata cttctgaagc cagtgttaaa 3473821 gcagacggct gtaaaaaaat agcgcctaac acggcttgtt cggcttctat attttgcgga 3473881 ggaagccggt cattcagaag gtctgtcatg ctaagcaccg tcctctcatt aaaaaatctc 3473941 caacctccat tctaccattt ctacagaaaa aaaatagaaa aattgtctgt ttcctgtttt 3474001 tttcagttag cagattggat cgtttcggac agtaacaagg cgggaaaaat gcaataaaac 3474061 ataagggagg aatgaaagat gataaagaaa tatgcgatta cacctaatgt tgatgcggac 3474121 ggctggttta ttgaggtgga gaatgtagcg ccgacagctt tgtatacgtc taaagacgcc 3474181 gctattgaaa aggccaaaca ggtggctaag gaaaacagtc cgtctaagct tgtaatttat 3474241 gaccagttta aaaatgtgga agaagaacac tcattttaat gaatgaaagc cttcgctgca 3474301 gcgagggttt tttagcggtt atcggtttat ttcatccatt ggatgcctat gtgcatcatc 3474361 aaatctgccg ctttttgata cagatcccac tccccgatcg aagcaaattt ccccatcagc 3474421 tcctgaagct ttaacctcat tgctatatat tcttcgaaag tgacagcttt ttcagtgtct 3474481 atttggtgtt ccttcagcat ttgttttaat aaggataacg gtgcgtgcat aagaaccctc 3474541 cttacctctt ttataacggt cattttccga ttgctctatt cctttgtgac atcttcttac 3474601 atttcacatc tgattcttgt acaatggaca gaagagagga gggatctttt gtgagacctt 3474661 tgcaaatttc tgccgaaact gcacaaaagc ttgcagagtc cttgaatctg ccgcttgaac 3474721 agatcatgca tatgcctcag catattctgc ttgccaaaat ggctgaactg caaaaagagg 3474781 acaaatcata gccttcattc acatacttgc ttacctgttt cgggataata tcatgtatat 3474841 gttagaaaag aggagtaact gctttgccac atccacataa taaaaaaatc caatcatttt 3474901 ggctgatcac cggcattatc tttatcgcct ttaacttacg gcccgcgatc acttcagtcg 3474961 gtccggtcat cagctctatc cgggcagagc tgcacatgtc caatggggca gccggttttt 3475021 tgaccgcact gccgctgctt tcgtttgcag ttctttctcc gcttgcacct aagcttggac 3475081 agcgcctcgg taatgagcga actttatggc taggtctcgt gatactgctg atcggtgttc 3475141 tgactcgttc taccggctat actgccgctt tgtttttcgg aacagcactt atcggcgtcg 3475201 ggattgcgat tggtaacgta cttttgccaa gcttaatcaa acataaatac cctgaaaagc 3475261 cagggatcat gatcagcctg tatacgacat caatgaatat attcgcagct ttagcatcgg 3475321 gtgtcagcgt tcctttagcg acccagatga atggcggatg gaaacaagcc tttctcttat 3475381 ggggcgggct ggctttactt gcattgctaa tctggatacc tcagctgcgc catcgagata 3475441 cggcaaacca gacaatgaag ctgcaatcca gttccatttg ggcttccaaa atggcatggt 3475501 atgtcaccat ctttatgggc ctgcaatcgt ttttatttta cagcagcatc gcttggtttc 3475561 ctgaaattct ccgttcacac gggattgata cggcaacagc cggatggatg gtatcactca 3475621 tgcaatttgc gagtctgcct tccacttttc tgacgccagt tttagctgac cgtgtgaaac 3475681 agcagcgcgg tatcgttgcg gcgctggcct cagtttatct gatcggcctt tgcggattat 3475741 tagcgggcgg aagccataca ttgcttgcca tctggatgat cattatcggt atcggacaag 3475801 gctccagcat tagtctggcc cttactttga ttggtctccg cagtgaaaat gcccaacagg 3475861 ccgctgcgct gtcaggcatg tctcagtcat tcggctacct gctggcagca gtcgggccaa 3475921 tctttgtcgg ctatctcttt gaccagacgc attcttggac gatgccgatt gtgcttctca 3475981 ttgctgccct gatcgtaatg ggagcagccg gacagggagc cggacgagat cgatacattt 3476041 tccagtcaga aaaacaaaga aattcagcat aaagcgggga agatatctcc gcttttttct 3476101 ttgaatattt atggtttatt cataagtttt tcatatttgt tttttacaat gagacaccat 3476161 aaagaggtga aaaacgatga aaaccaaacg attcgacgca gcccttattc ttattttgct 3476221 agcagcagct tttttgaata cgtatcacat ttggcaggat gatacagcaa accagtacta 3476281 tttggcggct gtaaaaagca tgacgcaaag cttccataac tttttttatg cgtcatttga 3476341 cccttctgga tttgtgacag tagataagcc tcctgtcgtg ttatggattc aaacgatttt 3476401 cgcactgatt ttcggtgttc acacgtggag tgtcatcatt ccccaggctc ttgccggagt 3476461 tggatctgtc ttccttctct acagaatggt taagccgact tttggagttg gagcggcccg 3476521 cattgccgca cttgtcatgg cactgacccc tatcgcagta gctgtcagcc ggacaaacaa 3476581 tatcgacagc atgcttgttt ttaccttatt gctcggttca acttgtctgc ttagggcagt 3476641 aaaacaaggc aagctggttt ggctgctgac ggcatttgcc ctgattgggc tcgcctttaa 3476701 tatgaagatg atgcaagcgt ttatggtatt gcctgcattt gtgttattct acctgattgc 3476761 atctcgggtt tctctgaaga aaaaaatcgg gtccctgctt ctgtctcttg tccttctgac 3476821 aggcctttca ctctcatggg cgattgcagt ggattcagcc tcttcctcaa gccggcctta 3476881 tgtaggaagc agccagacta actcagtgct agaactggcc tttggctaca acggcacaga 3476941 gcgtctgttt gggcaaacta cgggccttgc aaagggtgat atgaatgctg ctggcggagg 3477001 gaacatgcag aatcaagaca acatgcaagc gccaaatggc aacggttcat ctttttctca 3477061 gaacggtaat caatcattcg gaaaccattc acaggcgcct cagccgccta acggacaaac 3477121 cggcgctctc aatggaggcg gaggcacacc tcccacaggt ggcaacggac ctggaaatgg 3477181 agggcctggc ggcggaggcg gaaaaagcgt gaatatgttc ggcaccggtg atcctggacc 3477241 gcttcgtctc ttccaatcag cactttccgg ccaaatcagc tggatgcttc cattctcatt 3477301 gatcggatta ctgggcgcaa tcatcagctg gtaccgtgat cgccgcggac atgctgctaa 3477361 aatgaaagaa acgctattct gggcggcttg gcttgttccc gtggctggtt tcttcagcat 3477421 cgcaggattc ttccaccagt attatttgat tatgctggca ccgccgattg ccgccctttc 3477481 tggtatcgga tggtatacga tgcaccgctt atacaaaaat aataaagact ggtccagcta 3477541 tcttctgccg gcagccgtct tgatcacagc cgtgtttcag gtgtatattc tgagcgctta 3477601 tacaagccaa atcggcagtg tatggatgta tgtcctgggg ctcttaggac tgggcatcac 3477661 ccttgcactt ctgatgctta aacgcagcca tccgttcagt aagctgctga ccatcatcag 3477721 cttgtgcgtt ctgcttctca caccagttta ctggtcagca acgccgcttc tatacggtgg 3477781 caacagcgtc cttcctgaat ccggcccgca gctcaaaggc tcagcaaacg gcgggaacat 3477841 gttctcttca gaggtcgaca gcgggctcct gtcctatctg agaaaacaca ataccggcga 3477901 agagtattta tttgctactt tgacaaccgt aacagctgcg ccatacatca tttacgaaaa 3477961 tgaatctgtt atggcaatgg gcgggtttaa cggcacggat cccattctga ctgtgtcgga 3478021 actgaaaaaa ctgatcaaag aaggcaaagt gaaatacttc cttctgtcag aaaacaactc 3478081 aggcaacagc gaacttgttt cctggattaa gaaaaacgga aaagaaataa catctgacga 3478141 gtacagcggt tcctccagca gcacaaacag cgtgcaggga atgcgaagag gacctggcgg 3478201 agaaagccag caaactcttt atctcgtgga ataaaaaaag aggcttggat gaatccaagc 3478261 ctcttttcta ttaagcttct tcttttacat gtacctttaa cacagcctgc acttcaggat 3478321 gcagcttcac aggcacgttt gtatatccta atgcacgaat gccgtccggc agttcaagct 3478381 tccgcttatc tactttaatg ttatggtctt tttggagctg ttcagtgatt tgcttgcttg 3478441 tcactgaacc aaataaacgg ccgccctcac ctgattttgc gctaagctca acagtcagtt 3478501 tttctaatgt ctctttcaag ctcttagcct gctcaagctc agcaatggct tcttttttct 3478561 ctttctgctt ttgtccgttt aacgcgctga tgtttgacgc gttcgcttca accgcgaggc 3478621 cttttttaat tagaaagtta tgcgcataac cgtctgctac gtttttgact tcgccttttt 3478681 ttccttttcc ttttacatct tgtaagaaaa taaccttcat ctctgtacgc ctccctcaaa 3478741 atactcatct atggcgtgct tcagccgttc cagcgcttca gaaactgaaa tgccggacaa 3478801 ctgagtcgcc gcatttgtta aatgccctcc gccttccagg gcctccatga tgatctgaac 3478861 atttacctcg ccaagcgacc gagcactgat acaaaccgtt tgttcatccc gtctcgccac 3478921 cgcaaatgaa gcctcaacct cactcatcga tagcagcgaa tcggcagcct gcgcaatcag 3478981 cacttgatcg aagtattcct cttcattttc aggaagagaa gcaatcgcaa tgttatcttt 3479041 atagaggacc gtatgctgga tcagcttcgc ccgtttaata taggaatcaa cggtttcttt 3479101 cagaaacttc tgcaccagca ccgtgtcggc gccttttgcc cttaaataag aagccgcatc 3479161 gaaagtccgc gagcccgtgc ggagagaaaa gctctttgta tccactatta taccagctaa 3479221 tagggctgtt gcttcaatca tattgatttt taagcgcttc ggctgatatt caagcagctc 3479281 tgtcaccaat tccgctgtgg aagaagcgta tggttccata taaacgagca gcggatctct 3479341 gataaactcc tcacctcttc ggtgatggtc gatgaccacg atatgttcaa ttttattgac 3479401 cagccgttcc tccatgacga gtgacggctt atgtgtatca acgatcacaa gcagtgtgtc 3479461 atcattggaa atctccattg cttcttcagg cgtaataaat cttgaccaca gttcttcata 3479521 ttttttgatt tccccaatca aacgctgcac acttgatccg atttggtttg ggtcaatcac 3479581 gataaaacca tctttgttat ttgcctgagc cacctttaaa atcccgatcg ctgcgccgat 3479641 agaatccatg tcggggaatt tatgccccat gataatcaca ttgctgcttt cggtgacgat 3479701 ttcctttaag gcgtgagaaa tcacgcgggc ccgcaccctt gttcgtttct ccattgggtt 3479761 tgttttaccg ccgtaaaact tcaccttgcc gtttggcagc ttaatggcta cctggtctcc 3479821 gccgcgtccc agtgctaagt ccaagctgga ttgcgccaaa tcgccaagtt ctttcaggga 3479881 agagactgaa gccccgacac cgacgcttaa cgtcagcgct acaccgtcaa acgaggtttt 3479941 ttcccgcact tcatcaagaa tcgaaaactt cgaattttcg agttcagtta agatatgttc 3480001 attaagtaca gcaataaagc gttctgaaga cgtccttttc aagaagatcc cgtactcctg 3480061 cgcccaagcg ttcagcaaag atgtcacctg gctgttcatc gtgcttctcg tctggtcatc 3480121 caatccttgt gtcacatcat catagttatc aaggaaaata tatgccagga cggttctttc 3480181 gttttcatat agcttttcaa tctggatttg ttctgttaca tcaaagaaat ataagagacg 3480241 ctcatcccgt ttgatgacaa ccctaaactt gcggtcattc aatgtaaccg tttccgattc 3480301 cacctcttgt ttgataagcg gcactaccga ttcacaagta tcgtaaagtg atctccccac 3480361 taaagtgctt tcattaaaac aagaggaaag aaacggattt gcccattcta tataatattg 3480421 gtcattaaaa agcatgattc caatcggcat ttccatcaat gcctcttcac cgactttttt 3480481 caacctgtag gacaacgtag aaatataagc atcaatctct tgtcgaataa gagaatcagc 3480541 acgcttaata aaaaacaaaa taactgccag cagcagcact tcgacggttc ctaatatcca 3480601 gttaaaataa aagctgatga ggattgtaat aattgacaga gcaatcaatg catagatggg 3480661 ataccgaaac agcggttttt cataaaagct tggcatttct atcactcccc accatgtgag 3480721 taaaactcat gttcacttca ccttattcct tatatgaaag cccatatcta aaacgcctaa 3480781 aatgcgaatg gccgccatga agaccggatg cacaaaccca agtatgacag caatcacagc 3480841 cgcagccttt ggatattgtt tcttatggca atagaaaaag ataaatgata aaccttggat 3480901 gaaaatcaga aacccgagta taaactcccc atttaaagcg atagagtaca gcatttggcc 3480961 tttttctaaa ggcaaaaatg aaagcatgac aataatcaaa tacagtacta caacactttg 3481021 cggaaacttc aactctctaa aaggctttag attaggaata tcgggggaga atcgccttaa 3481081 gagcggctta gcgataaggt aactgaggaa agaaaaaata actcctacca tcacaatagc 3481141 tgttggaaaa agatattgaa cgatacccaa ttgttcttcc atcagtttta attgcttctc 3481201 aaactgccca gcattgcccg actgcttcgc tacagtttct acaatatcaa gagattgccg 3481261 gtattgtgtc attgcctcat caatgatatt gatacccaaa aactgaatgc ttatcacaaa 3481321 atagaagaca atactaagca tataaataag agcgcccgaa ataatggcgt gcccgggctc 3481381 tttccttttg aaaaaatgtc ccatggcaat gccggcgcaa gctgacataa aagctacaat 3481441 aagcccgtta aaggacccga caataaaaac aaccggaaga ctgacagcgc ccatccatat 3481501 ccctagcttc aatccatgtc tgatcgtata caagatcatt ggcagcggca gtgcaaataa 3481561 cagaattgtt ccaatcacag gaacataaac gaccagaagc gtaatgatcg caaacagact 3481621 gattaaaata gcaccttcca ttaaagctct cgtttgtttc acttagtcac ctcgtatcat 3481681 cctgaacata cgaatagaaa agagcagcat aaacgactgc tcttttgttc atcgctgcaa 3481741 catgctttgc accgaatgtt tttatatcat ctctaaattt tacttttata ttttaacata 3481801 agtccaaatc gcaagtaaaa tgacgctaat gtttcatgtg aaacatgaaa aaggaaaaga 3481861 cattctttga aaagaatgcc catcacaatt aatgtttatc atccataaag ccagaagatt 3481921 ccttgttttt ctttttcgtt tttctgacat acataaaaat taagatcacc agtaaaaggg 3481981 ttgttgcttg cagaacgccg ctgctaaaca agaaaaagtt ctttatcatg tcccacattg 3482041 tgtttcacct ctttgtgcat gttctcaacc cgtatcctat ataaggtgaa tttccctttt 3482101 taaaaacttc aaaacatcat gaacaacatt gagcgttggg catatgctga tatggaatct 3482161 gatcgataaa ggagaatttt cacatggatg aacgcagaac attggcttgg catgaaacat 3482221 tagaaatgca cgagctggtt gcttttcaat caaacggact cattaaactg aagaaaatga 3482281 taagagaagt aaaagaccct cagctcagac agctttataa cgtgtctatt cagggtgttg 3482341 agcaaaattt gagagagctt cttccgttct ttccacaggc tccgcacaga gaggatgagg 3482401 aagaagaacg cgcagataac ccattttaca gcggtgacct gctcggtttt gccaaaacat 3482461 ctgtccgcag ctatgccatc gcaattacag aaacagcaac acctcaatta agaaacgtac 3482521 tggtcaaaca gctgaatgct gccatccagc tgcacgccca agtttatcga tacatgtatc 3482581 agcatggata ttatccgtct tacaaccttt ctgaactgtt gaaaaacgat gtcagaaacg 3482641 ccaacagagc catttcaatg aaataaaaca agcagcaaag gagttccctt tgctgctatt 3482701 tctgctgatc cttcactaag ccgttcgaac gataagattc cagcacgtct ctgttggatt 3482761 ctccccattc tttcatttgc aaaacaatcg gttcaagcgt gcgcccaaat tccgtcagag 3482821 agtactctac cttgggcggc acctggtgat aaacctcacg gtgcacgatg ccgtccgctt 3482881 ccagctccct cagctggaga gtaagcattc tttgagtaat actcgggcag attcgccgaa 3482941 actcattaaa tcgtttcttg ccatctatca tgtgataaaa aagaattcct ttccactttc 3483001 cgccaatgac atctagagtg aattcaactg gacagccttc tttgttcggg tatatattct 3483061 ttttttcact cattcttgac cctccaatag tacctttttt gatactacat tacattttgc 3483121 aactaatcta cccagtattt tacacacctt ttctccttag ctcaaagaaa atgcttctta 3483181 ttcacatcaa tttttaaggg tttgcatgat tacacctgca gcaagacgtg ttaaactata 3483241 taaagattac actacttaaa aaaggatagg agctatcatg gaaaagatac ttattttcgg 3483301 acaccaaaac ccagatacag atacgatttg ttctgcgatt gcttatgctg atttgaaaaa 3483361 caaactcggc ttcaatgctg agcctgtccg cctcggacaa gtcaacggcg aaacacaata 3483421 cgcgcttgac tatttcaaac aagaaagccc gcgtcttgtt gaaacagctg caaacgaagt 3483481 aaacggcgtt atcctggttg accataacga acgccagcaa agcatcaaag acattgaaga 3483541 ggttcaggtt ttagaggtta tcgaccatca ccgcatcgct aactttgaaa cagctgagcc 3483601 gctttactat cgtgctgagc ctgtaggctg tacggctacc atcttaaaca aaatgtacaa 3483661 agagaataac gtgaaaatcg agaaagaaat tgccggcctt atgctgtctg cgatcatttc 3483721 tgattccctg ttatttaaat ctccaacttg cacggaccaa gacgtagcag cagcaaaaga 3483781 gcttgcggag atcgctggag tagatgctga agaatacggc ttgaacatgt tgaaagcagg 3483841 cgctgatcta agcaaaaaaa cagtggaaga gctcatttct cttgatgcga aagaatttac 3483901 actcggcagc aagaaagtcg aaatcgcaca agtaaacaca gtggacattg aagatgtaaa 3483961 aaaacgccaa gctgaattag aagctgtgat ctcaaaagtt gtggctgaga agaatcttga 3484021 tctgttcctt ctcgttatca cagatatctt agaaaatgat tcacttgctc ttgcaatcgg 3484081 taacgaagca gcgaaagtgg aaaaagcgtt caacgttaca ttagaaaaca acacagccct 3484141 cttaaaaggc gttgtttccc gtaaaaaaca agtcgttcct gtcttaacag acgcaatggc 3484201 tgaataagcc attacaattg cttcaaaatc cttgcggggt ttccgcctac aacagtatta 3484261 gcgggtacat ccttagtgac aacagatcca gaagcaatca ctgcgttatc accgattgtc 3484321 actcccgggt taatcaccgc ccggcctcca atccaaactt gatctccaat tgtcacaggc 3484381 ttaccgaact ccttcccgga tttcctttcg atcggatcaa gaggatgacc ggccgtgtag 3484441 atatgtacac ctggcgcaat caaacaatga cagccgatac gcacctcaca cacatctaaa 3484501 atgacacagt caaaattaac aaatgtatga tctccgatat gaatgtgata gccataatca 3484561 cagcggaatg tcggcaaaat cgtgacttga tccccaaccg aaccgagcag ctccttcaaa 3484621 agcttcgtcc gcactgcatc atcttccggt gtttcgttgt attgtctaat cagctgtctc 3484681 gcatgcttgc gttctagtaa tagttgttga tcttccgaat tgtataattc tccggctgcc 3484741 attttttctt tttctgtcct cagcatttaa gtcactccag atgtcagatt gtaatctcga 3484801 tcaaatttcc ttcatcatcc tcaatcacgc tttcatagta gccgtctcct gttgtcctcg 3484861 ggccgtttac tactgcgaaa ccatccgcct tcaatcgatc agtcagttcg tcaactttct 3484921 cccggctccc aacggaaaag gcaatatgtg cccagcctgt cattgtttgt gagggcggat 3484981 cggtcacatt cccttttttc ataatttcca gccttgctcc ggaatcaaac gtaataaaat 3485041 aagacttaaa atcttttttc tcattatgat acaaatcatt cgcttcgcca ttaaaatacg 3485101 attcataaaa agacttcatt cgctctaaat cattgaccca gaccgctgta tgttcaatct 3485161 gcatttcttc ctcctccttc gccttcaatg aagttataag gtatgaaatg catttcagtt 3485221 caagcttttt tcttaaattt atgctgaatt ttgatatcag cgggttcatc ctgcaaaaat 3485281 agagaaaatg ctgcgatgcc gagctgctca agattcaaat caagcgacgg aaaaccaaga 3485341 acacggctga tagaagtatt tccctcgcct atgatttcaa catcccaatt attctttttg 3485401 gcaaatagat gaattccagc tgccacttca tcactatttg cataaatagc agtcggaacc 3485461 cgcccgctca tataaaaatg ttcagctgcc agctcaccat cattcatatc gttgcatccg 3485521 gacagcatat ggcggtcttc caaccttccg cagacagctt tataggccgc agctttatca 3485581 gccgtgctcg ggctcctatc agcttctctg acacacgtaa aagcaatatt ctcatgcccg 3485641 cggctcttta aatagcgaaa gctctctgca taagcagttt ttctgtcatt aaaagcacaa 3485701 gggacatcaa tgtctccggt atcctcacaa gcgatgaccg gcccatattc ctgataagct 3485761 aaaatgctgt cccaatgatt ggcgcgggaa gtaatgatga gaccgtctat tttcttcgtt 3485821 cttaacagct ctaaatattt gatttcaata tcggggttat aattggtggg gagaagggtc 3485881 gttgcatact catgctgaaa agccgccttg gtgattccgt taacgatttt atcaaagcag 3485941 ggatgatcgc tataaggcag aatcacaccg accgtatggg ttttcccgcg aatgagatcg 3486001 attgcggttc gatttggtgt ataatccaat tccttcatga cttgatgaac aagctttctc 3486061 ttttcttcag atacatacgg atgatgattc aatacacgcg agacagtcga aacagataca 3486121 tttgccagtc ttgcgatctc ttttatattt gccatctctt tctccttttc atataaaaaa 3486181 agcagtaagt gtaaaatcct tactgctatc tcatcatata ttgatgataa gttcaacagg 3486241 acaatggtcg gaacccatga cgtccgctga tatgctggca tcttcaatct gttccttaag 3486301 gctttcagaa acaacaaaat aatcaatccg ccatccaata tttctgtccc gggcgccggc 3486361 acgatacgac caccaggaat aagcgccttc aagatcagga taaacatgac gaaaagaatc 3486421 aacaaagcca gcttctaaga aacgagtgaa tgcctctctt tcttgatctg aaaatccagc 3486481 gttattccgg ttcgcctttg gatttttcaa gtcaatctcc tgatgggcta cattcaaatc 3486541 accgcataaa atcactggtt ttttctgatc caattcaaga atataagaca gtaaagcctc 3486601 ttcccattgc atgcggtaat caatccgctc taatcccctt ctggaattgg gcgtgtaaac 3486661 agtcatcaca aacacgtttt caaattccag cgtaatcact ctgccttctt ggtcatgctc 3486721 ttctactccg ataccgtaga tgacctgcag cggttcttgc ttagaaaaaa cagctgtgcc 3486781 ggaatatcct tttttcactg cataattcca gtacacatga tagtcttcag gctggagatc 3486841 aacctggccg tcctgtatct tcgtttcctg aagacatata atatctgcat cctcttcttt 3486901 caaataagag aggaaatcca tttttctcat cacagcccgc aggccgttta cattccatga 3486961 aatcaacttc atgtttcatc ctccccccta taaaaaagag caagaacccg aaggtccttg 3487021 ctctttacat atcagcttac tcaccgctta cgtatggaag taaagccatt tgacgtgcgc 3487081 gtttgatcgc tgcagtcaat ttacgttggt atttagcgtt tgttccagtt acacgacgtg 3487141 gtaaaatttt accgcgctca gaaacaaact ttttaagaag atctacatct ttgtagtcga 3487201 tgtgcgtgat accgttagaa gtgaaataac acactttacg gcgtttcgca cgaccgcctc 3487261 tgcgtcctcc tgccattgtc atttccctcc tttctttttc attttaggcg ataatcacat 3487321 tagaatggaa gatcatcatc cgagatgtca atcggtttgc cgtcgttggc aaatgggtca 3487381 tcattaaagc tgttcccctg attgcgtctc tggttgtttt gatttccccc aaatggatta 3487441 tcattttggc ctccgccaaa gtactggcct ccgccgctgt ttccttcgtt gtatccacct 3487501 gaaccagaac cgccgccgtt tttcggctca agaaattgaa cactttcagc ttggacctct 3487561 gtcacgaaga cacgctgtcc ttgctggttt tcatagtttc ttgtttgtaa acggccatct 3487621 acgcctgcaa ggcttccttt tttcaagaag tttgcaacgt tttcggcttg tcttctccaa 3487681 gtgacacaat taatgaaatc ggcctcacgt tctccggact ggttcgtaaa tgtacgattc 3487741 acagcaagag taaacgtagc aacagccgca ccgtttggcg tataacgaag ctctgggtct 3487801 tttgtcagtc ttccgactaa tacaactcgg ttaagcataa gaaagaccac cttttaccat 3487861 tatatatttc aaaattgctt attcttcttc tttaacaaca atgtggcgaa tgatatcgtc 3487921 actgatctta gctagacggt caaattcttg aactgccgca gcgtcagatt gaacgtttac 3487981 gatttggtag aaaccgtcgc ggaaatcgtt gatttcgtaa gcaagacgac gtttacccca 3488041 atcctttgtt ccagtgatct ccgcaccgtt agaagtcaga acgttgttga aacgctcgat 3488101 aactgctttt ttagactctt cgtcaatgtt tgggcggata atgtacataa cttcgtactt 3488161 tctcatctgt ttgcacctcc ttttggacta agcggcccat aatgggcaag gagcaataat 3488221 tctattactc acaattttat attataccaa agctcttgtc cctttacaac tgcatcctat 3488281 acattaaatc ggaaatgaat aacatctccg tcttggacca catattcttt cccttcaagg 3488341 cggacttttc ctgcctcttt agctcctgcc ataccgccgc ccgcaagaag atcctcataa 3488401 gcaactgtct cagcacgaat gaagccccgc tcaaagtcac tatgaataat tcctgcacac 3488461 tcaggggctt tcatgccttt tttgaatgtc caagctctga cttcctgttc tccggctgtg 3488521 aaatatgttg cgaggccgag aagagagtaa gacgctttga tcagctgatc aagacctgat 3488581 tcttgaatgc ccagctcttc caagaacatt tgcttttctt cgccttcaag ctcagcgatt 3488641 tcagattcga tttttgcaca cacaacgata acttctgcgt tttcgccggc agcgtactcg 3488701 cgaatcttcg ctacattttc attgccagat ggatcagcaa cttcatcttc acttacgttg 3488761 gccacgtaca aaataggctt cgaagtcagt aaatggagct gcttcacaag cttttgctgc 3488821 tcttcagtga attctacaga tcgagcaggc ttttcactct caaacgcttc tttcagttta 3488881 gataaaatct caaactcaaa tacagcgtct ttatcttttt gcttcgcaag cttgctgacg 3488941 cgtgtaatcc gcttttcaac tgtttccata tcagcgagga tcagctcaag gttgatcgtt 3489001 tcaatgtcat caatcggatc aacctttccg gaaacgtgtg taatgttgtc atcggaaaaa 3489061 gcacggacaa cgtggcaaat cgcgtcaact tggcgaatat gagataggaa cttgttgccg 3489121 agtccttctc ctttagatgc gccctttaca atccctgcaa tatcagtgaa ttcaaaagca 3489181 gtcggcacag tcttcttcgg gttgaccagc tcagtcagct tttgcagacg atcatccggc 3489241 acctctacaa ttcccacgtt cggatcaatt gtacagaacg ggtagttggc tgattcggca 3489301 ccggcctgtg taattgcgtt aaatagtgtt gattttccga cgttcggcaa accaacaatt 3489361 ccagctgtta aagccattct ttcatctcct ctatataaaa ccgtcattgt atgaacgtat 3489421 tttgaaccta gagcaattat aaggaggttc actggaaaag acaagctgac aaaaaagcat 3489481 tttcagcttg ccaatccctt tgattatgct tttttcaagc ctactaaaca gtcaaaaagc 3489541 gtacttccca ttccattatc agaatttgta tcatttgtca gtgcattgac tgaccctcca 3489601 aaagccgccc acatgccttc atctatatta atcgtcttcg catgagcctg cttcatcact 3489661 ttcaccttgc ccttcatgct tccgcggtca ttaaagatga caacttcgtc tccatcctga 3489721 agatcctgcc cagccgctat atctggagaa atatcgacct gaacgtgctg aagcttttca 3489781 ataaacggca catgctgtga atgattggaa cgctgcggat gaatggataa gagcgtataa 3489841 gggtactttc cagctaactc ctcattatgg aaaacagatt cttcgggcac atttaattga 3489901 agcgagccgc taaatccttt ttgctcagct agcgacgaag taaattcaaa ttttccactc 3489961 ggcgtcaaaa actgataatc atcccacggc acctgtttta ctggaagagg gaggtggcct 3490021 ttttctttta aacgctcaag tgtcacatcc tctgcttcca atgaagaaag ccccatctct 3490081 aaaaattctt gagtgctgta ttcaaacagc tcgccaaacc caagacgttt tgcaagctct 3490141 gaccagatcc agctgtccga tttcgcttca ccctgcggct ccacaagctt cttcccgtac 3490201 tgaacataat gatgatacat actggaatag tagatatctt cttcttcaaa aacagtggca 3490261 gtcggcaaaa cataatcaca cagctctgcg gtatccgtca taatggaatc aatcgcgacc 3490321 gtcattggaa ccttttcaaa tgcttgtctc accttatttg tattcggcac ctgagtcagc 3490381 ggatttccgc acgtcacaat aatcatctca atcgcaggat cagcagcggt caacacttct 3490441 tcagcctgtg tcatcattga aaaagaacgg gatgttgttt ttaattccgg cagcgtcagc 3490501 tttgtttttg caaagctctc accaatctgg acatttccga aattcgcgcc gccgccctta 3490561 attccgacat ttccgcttgc cgccacaagt gcatcaatcc aacgaatcgt tcccccgccg 3490621 tttttatatc gctgcatgcc aagccccata aaagtagaca ccggaccatc agcatacaaa 3490681 cctgccaaat actccagctc ctccatagaa gtttctgttt tcacaataaa ctcttccaga 3490741 gaaacggtct tcaaaagctc tttcacatca tcaaaaccga cagaatgctc agaaataaac 3490801 gtttcatccg ttcttcccat ctcaatcaga accttcaaaa cggctgccgc aagccagccg 3490861 tccattccag gctttacaga gatatagcgg tcggcaagct tagcagtcgg gttgaagatc 3490921 ggatcaatca ccgtaatcgt ggcgcccttc tttttcacct gctgcaagtg atggtataag 3490981 tgcatatttg ttcttgatac atttcttccc cacacaacaa catgcttgct gttgtaaata 3491041 tcaagcggtc cgtgaccgta cgaacggcca aaatcccagc tttgcgcctc gataccggag 3491101 ccccagcata tgcttccgac gatttcggtc acgccgccat atccattaaa aaaacgctga 3491161 tcaagcgctt ttaacagacc gttattcgca taatcatggc tgtgcaaaac agcagtcgtc 3491221 tccgacgttt ccttgatttc ccgaagttta tcggcaattt catcaagtgc ctgctcccaa 3491281 gaaatccgca caaactcgcc attttgtttt ttcattggat agcgaagccg atcaggcgaa 3491341 tttgtttttg tctcaagcat tctgccgcgg ccgcagattt taccttccgt aatcggatgg 3491401 tttggatctc cgtccacttt tgttaccttt ccatcatcaa cagtcaccaa aaagccgcag 3491461 ctgtcccaac aattcagcgg acatgccgac tgatgcactt tgctcatcgc cgtcttctcc 3491521 ttaccttcta tatgaaaaag catgagtgtc ggcctattta tgaagtaggc tcctcatgct 3491581 tgactagtac tttttttagt tttctttcaa attctcttct cggaatcata acactgtgag 3491641 agcatccctc acacttaatt cgaatatcca ttcccatgcg tataattttc cagctgttcg 3491701 ctccgcatgg atgcggtttt ttcatttcta cgatatcatt caggccaaag tctttatccg 3491761 ccaagaccct tcacctcttt tcctaaactg ctgtatctat tgtacaaaaa aactgatcat 3491821 aagagcaatc aagatacccg aaaagaaata catcctctta tttccattta ctcaaaatag 3491881 gatataagag cagacaaact aacaaataca aattgagcat cccatatatc ggatacaaga 3491941 acgcgatcaa atcagaaaat ccgaaagaag taaaaggtac cattaacact aacaaaatca 3492001 acacaatcat ccatctcggc atatgaataa acgccatcag ccggctggac aaacccagca 3492061 aaccagctac cgtcgtcgtg taaatcgcca ggcacagcac cgccgtcata cataaaaaaa 3492121 ggaaataagg cgcaccctcc agaacggcaa acagcggtat ttcaaactga gaaagggagc 3492181 ccgccagctc caccaacgtt tcattataaa caaatgagat cacgccaaaa ataagaccgc 3492241 ttgccacact tgcgattttt gcttctccga gccctttcat ctctttccca acagaggata 3492301 aaatcgcaac aactgaaagg atgtttaaag aggtaaacgt aatgctcgca ggccagttat 3492361 actgctggga caaatcaatc gtccacgtat ggtgatgtgt gctctgaaag gagatcagcg 3492421 catataaaag ccccgctact aacacaggaa tcaaaatact atttatagat aatattcctt 3492481 tcacatccca caaaaacaag cacactgtca cgatgcaaat cagcgtgatt ccccaccaga 3492541 aaggaagctt gtacatttgc agggtcacac cgcctccggc aatcatcacc atagtcgtcg 3492601 aaaacaaata aaaaatgatg aggacatcat aaattttcgc cagccatggc cccattaaat 3492661 gctccagaac cggcagaaaa tgagtggatt gaaccttaaa actgattttc atcacaatat 3492721 aagacgagaa aatgaacata attgtaaaca gcacaatagc aagtccgctt tccgccccaa 3492781 aaaactgcca tatctcctga ccgctcgcat atccggcccc gatcaggctc cctaatatga 3492841 gcagcatcca cttcattccg gctctccaca acactatcac ctcatagaca aagttcagct 3492901 tgttcccgtt attgttacta tataaataaa ggaaagcaaa catgccatat tttcatagac 3492961 atttgaacac aagctgaaat tatcatacga aatacacata aaaaagactg ctaatacggc 3493021 agtctaaaaa gagatattta tttgtttgtc cgcggaatga agaagtgaac ttcactcttc 3493081 acttttttct aaccattcct acctattcaa gtgtttcata agcagaccat tgcttgatca 3493141 tgatcgaggc aatgggggac aatacttgta atcgcccact aaccattcat atcatgccct 3493201 ctactttttt aaaatctctg gtgccataca caaagcataa aaaatcatac tgctggatat 3493261 actgtaaaca accttacata actacacaca ccatagcaat tctgttacct actataacaa 3493321 ggaagtgaaa cccatgaatc gaaaaggcgg gcttttttct tctcaggaac gagtaaagca 3493381 atatgtttca catacagatg ctgcagcggc aaaacaaatc caaaccatcc tttcttcatc 3493441 cttacgtaaa gctgctggca aaccaattgt cgtggtttgt atcggaacag accgttcaac 3493501 cggtgactca ttaggcccgc tcgtaggaat gaaactcaaa cagatgcagc tcaccagatt 3493561 ccatgtctac ggaaccttat ctgaccccgt ccatgctgtg aacatgaagg ataaaatcaa 3493621 tgacattcat aaattacata aaaacccatt tgttatagca gtcgatgcat gcttaggccg 3493681 cgttaagagt gtgggttcat ttcaaatcgg ggacgggcca ttaaagcccg gagccggtgt 3493741 acaaaaagac cttcctgaag tgggagatct tcatattaac ggaatcgtga atgtgagcgg 3493801 ttttatggaa tattttgtat tgcaaaatac tagactcaac ttggtcatga atatggcaaa 3493861 tgttctagcg gaaggtttga gtttaacaga tcggacagag tggaggcaag aacgccttaa 3493921 cccgttgcaa aggctcactg ggcgcatata aaataaaaac catcttcgtt tgaaagatgg 3493981 ttttttcatt tatgattctc gttcagacaa aagctctaaa atccggtcaa ggtcttcatt 3494041 agagaaaaat tcaatttcga ttttgccttt tttcttctgt cttttaatat taactgttgt 3494101 tccaaaataa ttttggagat aggattcccg ttcttttaga accgcatctt tcacaggttc 3494161 ttttttcttt gtttcacgtg gaacattctg attcaactgc tgaatcagct gctcaagttg 3494221 gcgaacattg agctgctccg caatcacttt ttgtaccagc ggttcaagct tatttttgtt 3494281 ttttaagcca agaagcgtgc gtccatgtcc catagaaagc gtgccttcgg caataagctg 3494341 ttgaatattt tctggcagtg tcagcagtct taaatgattc gcaatatgcg gtctgctttt 3494401 cccaagacgt ttggcaagct gctcttgtgt gagatctaag tgtttcaaaa gggagtcata 3494461 tgcctgagcc tcttcaagcg gagataaatc ttcacgctga aggttttcta ataaagcaat 3494521 ttccctcatt aacgcctctg ataattcacg gacaatggcc ggaactgtat ctaaacctgc 3494581 cagctttgcc gctcgaaaac gccgttcacc cgcaacaata tcatagcctt ttaaagattt 3494641 tctgacgata agcggctgaa gaatgccatg ctgcagcaca gattctttta gttcagctaa 3494701 tgcctcgtca tcaaagtgtt ttcttggctg ataaggatta gggcgtaaat cggcaatttt 3494761 aatttcttca actgtctctt cagacaaatc tacctgatta aataacgcat taatcccttt 3494821 tccaaggcct ttagccattc gcagccactt cctttgctaa atctaaatat acttccgcac 3494881 ctcttgaccg cggatcgtat aaaatgatgg gttttccgtg actcggtgcc tcactcagac 3494941 ggacattacg cggaataact gtcttatata ctttatccct aaaatacttt ttaacctctt 3495001 caatcacttg aatgccaagg tttgtccggg catcaagcat tgtcagcaat acaccttcaa 3495061 tcattaaatc agtattcaaa tgcttttgca caagacgtac tgtatttaat aactggctga 3495121 gaccctccaa ggcataatat tcgcactgta caggaatcac aacggaatcc gaggcagtaa 3495181 gggcattaat cgtcagcaag cccaatgacg gcggacaatc aatgataata taatcataat 3495241 tttgctttac tgcttcaagc gctctcttca atctcacttc tcttgatatt gtaggaacca 3495301 gctcgatctc agcccctgca agctgaatcg tcgcaggaat cacatccaag ttctctactg 3495361 tcgttgcttt aataatatct attacatctg catcatctac taaaatatcg tacacacact 3495421 gctctacatc ggctttttca atccctaatc cgcttgtcgc atttccctgc ggatcaatat 3495481 ctaccagcag aacccttttc cctatgtaag ccaaacatgc cccaaggttg acagacgtcg 3495541 ttgttttgcc gaccccgcct ttttggttcg taattgctat gatttttccc acgatgtcac 3495601 ctactttcac atgaacatgt actatcttgc ttctattcta tcaaaaaaag attaaagcgt 3495661 ttcatttttt tcatcatttt gttccgaatc agaagggaaa taattgaaaa ttcaagcacg 3495721 ctttatgctt tctcttataa attctgcaat ttctatgttt ttttgactta aaaaaggaat 3495781 ttcttaaaga aaaaaagaag aagtcacagt acagaacgtg gaaacaggat ggtgagaaaa 3495841 tggtttatca aacgaagaga gatgtacccg ttacgctgat gattgtgttt ctcatattac 3495901 tgatacaagc agatgccatt gttccttttg tgctgggaaa tatgagagtt tccggctgga 3495961 tcatttttat tctgctgact cttttaaatg gactcatcat ttggagcttt attgacctaa 3496021 aatatgtatt gaaggaacac catctgatca ttaaagccgg attgatcaaa catcaaattc 3496081 cttatgaaaa catcgataaa gtcgttcaaa aaaagaaact atggtccggt tttcgtctga 3496141 tcggctctcg ccatgccatc acaatatatt atcagggggg atggggacat gcagtaattt 3496201 caccgcaaaa atctgaagaa tttatccaca agctcaaaga aaagaattct aatataataa 3496261 tattcactaa aagtaagtga ttaccttttg ttaaaaatat aaaaagctct cctgcttttc 3496321 aggagagctt ctattttggt atgcgaatcg ttaattgaat atattcttca aattcttctt 3496381 cttccgtatt caattttaca ccgctgtctt ccaccattga tagtgactgg cgaatcgtgt 3496441 tcatcgcaat tcttgtatct ctgctgaatg ctttgcgtct cggctttggc tttctctggc 3496501 cttgctccag cattttcacc acgcggtctt ctgtctgctt tacatttaaa cttttctcaa 3496561 taatctctgt gagcagtgtg acttggagct caggctgttt cagcggaatc agtgctctgg 3496621 catggcgctc ggtgattttc ttctccataa tcgcctcttg gaccggctga ggcagcttta 3496681 ataaccgaag cttattcgcg attgtagact gcccttttcc taagcgctgt gcgagtgcct 3496741 cctgtgttaa atcatgcagc tcaagcagcc tagcataagc atgcgcttcc tcaatagaag 3496801 acagttcttc ccgctgcaag ttttcgatta acgccacaga agcggtttcc gtgtcggaaa 3496861 aatccttaat aattgccgga atcttttccc actcaagcga ttgcaccgct ctccagcgtc 3496921 tttcacctgc aatgagttcg tattggcctt cttcttctgt atgcctaaca acaatcggct 3496981 gaataatgcc gtgtgtatga atggtcattg ctaactcttt gattttttca tctgagaaaa 3497041 tggtgcgtgg ctgaaaacgg ttgggaacga tagcatttac cggtatttcc agaatctctt 3497101 ctttgtttgt atcatgttca gcaatctccg gctcctgttc cttctcacca agcccgaaga 3497161 aacgagagaa tgaatgcttc atgtacctac accaccttta aaaactgcca tttttataat 3497221 tctattttct catggttttt cctgctgtac atccatcaat tttgatgaaa atatgatggt 3497281 attgtcatat caggctgtct aaattaccct tcaattggcg atttattagg agttcccggt 3497341 tttcttggat acttcttagg tgtatttttt attttgcgta tcaccataat attacgatcg 3497401 ctttcttcaa taggcagctt aaaagaatgg atattctcaa gttctcctcc aagcgtcgtg 3497461 attgcttttt tgcctgcatt cagttcttct tcagctgatg cggcttttaa agcaacaaat 3497521 aaaccgtttt tcttcaccag aggcaagcaa agctcactca aaacagataa tctcgcaact 3497581 gcgcgcgccg tcacaatatc atagctttca cgcacgtctt tccgttgccc gaacgtttca 3497641 gctctgtcat ggcagaatgt tgtattctcc aattgcaaag cttcagacaa cttttctaaa 3497701 aacgtaatcc gtttgtttag tgaatccacg attgtgacat ggaggtgcgg aaagcatatt 3497761 tttatcggca gacttggaaa acccgctccc gctccaacat cacaaatcgt gttcacctga 3497821 ttgaagtcga cataaaaagc agctgtaatg gaatcataaa aatgctttaa atacacttct 3497881 tttttctctg ttattgaagt cagattgatt ttttcgttcc attcaaccag catgtcgtaa 3497941 tacagctcaa attgctccag ctgacgggga gaaagggaga tccctttttc cgccaaacca 3498001 gaagtgaatt cttcaatatt catgccgtca tcctttctac tcggctatct tcgcaatgcg 3498061 tccctgctct aaatacacca atagaattga aatgtccgcc gggtttacac cggaaatgcg 3498121 ggaagcctgg gcaacagaca aaggccgtac atttttcagt ttttgacgcg cctcggtcgc 3498181 aatcccctta attgcgtcat aatcaattcg gtctggaatt tttttatttt ccatcttctt 3498241 cagtttttcc acttgctgaa gagatttttc aatatatcct tcatatttca cttggatttc 3498301 tacttgttct gccacgtctt gaggaaccgg cacttctggc ggcgccagtt ttgtgactgt 3498361 ttcatagttc atttcaggac gtttcatcaa gtctgtgccg cgaactccat ctttcaattc 3498421 gcttccgcca agagaacgga tatattcttg attttccgga gacggcttga taattacaga 3498481 atgaagacgt tttttctccg cctcgatcgc cgcttttttc ttctcaaaag ccgcatagcg 3498541 ctcatcagaa atcaatccaa tgcgatgtcc gatttctgtc agacgcaaat cagcattgtc 3498601 atggcgaagc agcaatctgt attccgcacg tgatgtcaaa agacgatatg gctcattggt 3498661 accttttgtc acaaggtcat caatcagaac accaatatag gcgtcagaac ggcttagaat 3498721 tacttcttct tttccaagcg cttttcgtcc tgcattgatt cccgccataa tcccttgtcc 3498781 cgcagcttct tcataaccgg atgttccgtt aatttggcct gcagtataaa ggtttgtgat 3498841 ttttttggtt tcaagtgtcg gccatagctg tgtcggtacg attgcatcat actcgatcgc 3498901 atagccggct ctcatcattt gcacgttttc aagtccagga atcgttgcaa gcattctttg 3498961 ctgtacgtct tctggaagac ttgtagataa accttggaca tagacttcct gtgtatttct 3499021 gccttccggc tcaaggaaga tttggtgacg cggtttatca ttaaaacgga caactttgtc 3499081 ttcaatggat gggcagtatc ttgggcccgt acctttgatc ataccggaat acatcggtga 3499141 acggtgcagg ttgctgtcaa taatctcatg tgtctcaggg cttgtatatg tcagccagca 3499201 agggagctga tctgtgatat attccactgt ttcatatgag aaagcgcgag gcacatcgtc 3499261 accaggctga atttccgttt tgctgtaatc aatcgtgtcg cttttaacgc gaggcggcgt 3499321 acctgtttta aaacgaacaa ggtcaaaacc gagttcctcc aaatgctcag aaagcttaat 3499381 agaaggctgc tggttattcg ggccgcttga gtaagacaga tcgccaagaa tgatacgtcc 3499441 tcttaaatat gtccctgtcg tcatgacaac tgctttcgca cgataatgtg cgcctgtttg 3499501 tgtaataacg cctcggcatt cgccgtcttc aacgatcagc cgctccacaa ttccttgcag 3499561 caatgttaag tttggttctt tttcaagcgt atttttcatt tcgtgctgat attggaattt 3499621 gtctgcttgc gcacgcaatg cacgaaccgc aggacctttt cctgtattca gcattctcat 3499681 ttgaatatgt gttttatcga tgtttcttcc catttctccg ccgagcgcgt caatttcgcg 3499741 gacgacaatc ccttttgcgg ggccgccgac agacggatta catggcataa atgcaaccat 3499801 atctaggttg atggtcaaga caagcgtttt ggcgccttgg cgtgcagatg cgagggcagc 3499861 ctcaacaccg gcatgcccgg cgccaatcac aatcacatcg tattggcctg cttcataccc 3499921 catgattcta gttcctcctt taattatttt cctaaacaga attgagaaaa gagctgatca 3499981 attaagcttt cgtggacaga atctccaatg atttccccta aaagctccca gcatcttgta 3500041 aggtcaattt gcaccatgtc gatcgggaca tcctgttcga tgccgctaag cgcatcttca 3500101 atggcgcgtt ttgcttgctg taaaatagtg atgtgacgtg tgttgctgac ataagtcaga 3500161 tcaccgcttt caatggcacc cgtgtagaac agtgattgaa tcgcttcttc cagatcattg 3500221 atgccttcct cttttaaaag agatgtcgta acaactggac gtccattggc aagctcacgg 3500281 acacgttcag tgtcaatctt cggctcaagg tcagtcttat tcaaaatcac gataacatcc 3500341 atgccctcaa cggcttcaaa aagcttcacg tcttcttcag aaagctcttc actataatta 3500401 agcacaagta aaatcaggtc cgcttccttt aggacctggc gagaacgttc aacaccgatt 3500461 cgctcaacaa tatcctctgt ttcacgaata cctgctgtat caaccagacg aagcggaacg 3500521 ccccttacat tcacgtattc ctcaatcaca tcccgtgtcg ttccgggaat atcggttaca 3500581 atggcttttg cctcatgaac gaggctgttc agaagagatg attttcctac gtttggccgg 3500641 ccgataatga cggtagaaag accttcacgc aagatttttc cttgctcaga agtcctcagc 3500701 agcgtctcaa tttccttttt cacggcggtt gccttttcga ctaaaatctg atgcgtcatt 3500761 tcctctacat catcatactc cggataatca atattcacct caacatgggc cagtgtttct 3500821 aaaatctcac tgcgcaaacg gcgcaccaaa gcagaaagac gcccttccat ttgattcata 3500881 gcaacgttca ttgcccggtc cgttttcgct ctgattaagt ccataaccgc ttccgcctgt 3500941 gaaagatcga ttcggccgtt taaaaacgca cgtttcgtaa attcaccagg ctctgccagt 3501001 ctcgctccct ctctcaatgc aagctgaagc acttggttca cagtcacaat tcccccgtga 3501061 cagttaatct cgatgacatc ttctcgtgta aaagttctcg gcgcttttaa cactgatacc 3501121 attacttcct caacgacacg atccgaaggt ctgtctacga tatgaccata atgaatcgta 3501181 tgtgattcga ccgagctgag tgttttcccc ttcggtccct tataaatttt atctgcgatt 3501241 tgaatggctt ctggtccgct caaccgtaca atcgcaatcg cgccttctcc catcggtgtg 3501301 gaaattgccg caattgtatc catgttgttc acctctcttt acttatactt catctatata 3501361 aaaaaatttt tattatgcca aaactaaaag ataacatagt ttggttcgaa gtggaagatt 3501421 tgttatccac agaaatagaa attcgtccct tattacttta acttatccac atgtgaataa 3501481 caattaattt tatttcctga acttcctttt tatcaacagg atacacctaa aaagaaaaaa 3501541 cttaaacggc aaaaccttga tattactagg aaaagtagat ttttcggata caaaaaaacc 3501601 gaaatccaat ttttatcgga cttcggtttt atgctatctt ttatgggaaa taacgagatg 3501661 acgattttcg ccttcaccca ttgaatatgt tttgatctgg tggtttgcat atccagaaag 3501721 agtatcgtga ataatttttc tttcgctgga cggcatgggc tcaagctgga tggatttttt 3501781 cgttttcaaa acctggtcag caagcttgat ggccagctgg ctcagtgttt cttttctttt 3501841 caaacgatag ttttctgcat ccaccgtcac atttttatat tggcctggat aacggttaag 3501901 ggcaagctgt gtcaaagttt caagggcgtt taaagtttgt cctcttttcc caatcaacaa 3501961 tgctgccttt tcacctgtta tatgatatct cactgtcttt ttgctttctt gaacagtcac 3502021 atcagacttc ccggcaatgg cttcggcaat cgtttgaaga tataacttcg cttgctgaat 3502081 cggatcaatc ttttcaacca gctttacgat cgcaggcttt ttaccgaaaa taccgagaaa 3502141 ccctttgttt ccctcttcaa taacagtaat ttctacctta tccttcgtta atcccaactc 3502201 ttgcaatccg gactgtactg cttcatcgac atttcgccct gcagcagtca cattcctcac 3502261 tttttctttc ctccggcttt ttgcggctca ggattttttt taatatcagg tcctttaatg 3502321 aggaaagttt gcgcaatcat aaacaagtta ccaactaccc aataaagaga aagagccgcc 3502381 gggaagttga tcgcaaatac gataatcata attggcataa tccaaagcat catcgccatt 3502441 tgcggatttt gctgcgcatt gccagccatc atcagttttt gctgaacaaa tgtagcgaca 3502501 ccggcaacga taggaagaat atagtaagga tctttttctc ctaagtcaaa ccataagaag 3502561 ctatgctctg aaatcgcctg ggttctcatg atcgcatgat agaatccaat taaaatcggc 3502621 atctggatca aaatcgggaa acatcccgcc aatggattga caccatgctt ttggaataaa 3502681 gccattgttt cctgttgaag cttttgctgc gttttttgat cctttgagct gtatttttct 3502741 ttaagctttt gcatttccgg ctgtaaagcc tgcatcgctt tcgaacttct cagctgctta 3502801 atcatcagcg gtaaaattaa taaacgaatt aaaatggtaa ctagaataat tgaaagcccg 3502861 tagttatctc ccgtcaattt cgctacatac gtaatgagct cagacaatgg atatactacg 3502921 tacttgtccc agaaatgcgg actatctgca gtgatcggct ctttcacact cgagcatcca 3502981 gccaaaagca tgaatacgcc aaccatactt aatagcaacc ctattctcct tttcaacaac 3503041 atttcctcct ataattaatc tttacactct tttattgcaa agcatacttg tatgtatttt 3503101 agcatctttc agttttaaat ggtgtctttt tctgatcaac cagaaaggaa gcgcttttaa 3503161 aagttgtaag aaagcagtgg tgatgcctac tttgacgaag atttcttata taatgaagac 3503221 tttctgaata gatgctgcag actttttttc gtttcctcat atgtcagctg gctcgccggt 3503281 tttctggcaa taatgatgta atccttttcc ttcagtctct ctttctcttc aagaaaggcc 3503341 tgccgaatca aacgtttgat ccgatttcgc atcacagcat tgccaatttt tttgctgacg 3503401 gaaagcccga cacgcagttc atcattttca ggctgatcaa gcgtatataa gacaaactgg 3503461 cggtttgcaa ctgatgtccc atgtttaaac actttttgaa aatcttcatt tttctttaaa 3503521 cgatttcgct tcttcaaatg actcactccg atactggctg gcagaaactt ttaaaattta 3503581 ttatgaacat gagatgcatc tgaaccagga agcatgcccc ggttcattac gcatcacatc 3503641 tatcttttcc cataacgtga aaaaagacca ctgacattat tcagtggcct aagctgataa 3503701 tacttttctg cctttgcggc gacggcgtgc taaaactaga cgaccgtttt ttgaactcat 3503761 acggcttctg aagccatgaa ctttgctgcg tttacggtta ttcggttgga atgttctttt 3503821 catttatgac acctccctcg aggaatagct gttaaagaca gtcttactta ttatatttgc 3503881 gttacctatt cattgtcaac ttcactagtg cttttatttc ttgcaaccat aataggatac 3503941 catacctttt caactttcga aaccttattt tttagattcc ttaattttac ggaaaaaaga 3504001 caaattcaaa caatttgccc ctaaaatcac gcatgtggat atctttttcg gcttttttta 3504061 gtatccacag aggttatcga caacattttc acattaccaa cccctgtgga caaggttttt 3504121 tcaacaggtt gtccgctttg tggataagat tgtgacaacc attgcaagct ctcgtttatt 3504181 ttggtattat atttgtgttt taactcttga ttactaatcc tacctttcct ctttatccac 3504241 aaagtgtgga taagttgtgg attgatttca cacagcttgt gtagaaggtt gtccacaagt 3504301 tgtgaaattt gtcgaaaagc tatttatcta ctatattata tgttttcaac atttaatgtg 3504361 tacgaatggt aagcgccatt tgctcttttt ttgtgttcta taacagagaa agacgccatt 3504421 ttctaagaaa aggagggacg tgccggaag //